bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Influencing Capture and Retention of Razorback Sucker in Light Traps
Authors: Vlaming Catherine M. , Bestgen Kevin R. 
Published: July 2020

Abstract
Light trap captures of larval, endangered Razorback Sucker Xyrauchen texanus are used to guide flow release timing from reservoirs and measure Razorback Sucker annual reproductive success in the Green River, Utah. However, little is known regarding efficacy of light traps to capture or retain larvae under variable and field-relevant environmental conditions. We conducted laboratory experiments to investigate the effects of light trap set time, fish release distance from trap, light presence, turbidity, fish density, and cover on capture and retention probabilities of five early life stages of Razorback Sucker. Mean capture probability of protolarvae prior to swim bladder development (7–9 mm TL) was 0.40 (range = 0.28–0.55) over various treatments but rose to 0.76 (0.73–0.80) after swim bladder development in later protolarvae (9–10 mm TL). Mesolarvae (11–17 mm TL), the most common life stage captured in field sampling, had a similar mean capture probability (0.86; 0.82–0.90) as later protolarvae. Capture probabilities of metalarval (mean = 0.42, range = 0.21–0.63; 15–24 mm TL) and juvenile (mean = 0.24, range = 0.20–0.28; 22–37 mm TL) life stages were lower. Larvae retention probabilities were generally &gt; 0.75 and increased to 0.97 for juveniles. Longer set times positively influenced capture probabilities, though capture probabilities were similar in 1-, 3-, and 5-m release distances and relatively high (&gt;0.75) for most the commonly sampled life stages in standard conditions. Light presence in traps greatly increased capture and retention of larvae compared with unlit traps. Our results confirm that light traps may be useful to detect first presence of Razorback Sucker larvae in Green River backwaters each spring, which triggers Flaming Gorge Reservoir releases to inundate floodplain wetlands and for annual monitoring of reproductive success. We also provide recommendations for gear set up, deployment, and techniques to increase capture and retention probabilities of Razorback Sucker larvae.
H3K27me3 expression and methylation status in histological variants of malignant peripheral nerve sheath tumours
Authors: Lyskjær Iben , Lindsay Daniel , Tirabosco Roberto , Steele Christopher D , Lombard Patrick , Strobl Anna‐Christina , Rocha Ana M , Davies Christopher , Ye Hongtao , Bekers Elise , Ingruber Julia , Lechner Matt , Amary Fernanda , Pillay Nischalan , Flanagan Adrienne M 
Published: July 2020

AbstractDiagnosing MPNST can be challenging, but genetic alterations recently identified in polycomb repressive complex 2 (PRC2) core component genes, EED and SUZ12, resulting in global loss of the histone 3 lysine 27 trimethylation (H3K27me3) epigenetic mark, represent drivers of malignancy and a valuable diagnostic tool. However, the reported loss of H3K27me3 expression ranges from 35% to 84%. We show that advances in molecular pathology now allow many MPNST mimics to be classified confidently. We confirm that MPNSTs harbouring mutations in PRC2 core components are associated with loss of H3K27me3 expression; whole‐genome doubling was detected in 68%, and SSTR2 was amplified in 32% of MPNSTs. We demonstrate that loss of H3K27me3 expression occurs overall in 38% of MPNSTs, but is lost in 76% of histologically classical cases, whereas loss was detected in only 23% cases with heterologous elements and 14% where the diagnosis could not be provided on morphology alone. H3K27me3 loss is rarely seen in other high‐grade sarcomas and was not found to be associated with an inferior outcome in MPNST. We show that DNA methylation profiling distinguishes MPNST from its histological mimics, was unrelated to anatomical site, and formed two main clusters, MeGroups 4 and 5. MeGroup 4 represents classical MPNSTs lacking H3K27me3 expression in the majority of cases, whereas MeGroup 5 comprises MPNSTs exhibiting non‐classical histology and expressing H3K27me3 and cluster with undifferentiated sarcomas. The two MeGroups are distinguished by differentially methylated PRC2‐associated genes, the majority of which are hypermethylated in the promoter regions in MeGroup 4, indicating that the PRC2 target genes are not expressed in these tumours. The methylation profiles of MPNSTs with retention of H3K27me3 in MeGroups 4 and 5 are independent of mutations in PRC2 core components and the driver(s) in these groups remain to be identified. Our results open new avenues of investigation. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland.
Patient and health service factors associated with delays in cancer treatment for children without social security in Mexico
Authors: Zapata‐Tarrés Marta , González‐Domínguez Elizabeth , Doubova Svetlana V. , Menendez‐Auld Nadia , Cruz‐Medina Cynthia Shanat , Gonzalez‐Ramella Ramón Oscar , Vega‐Vega Lourdes , Guevara‐Espejel Claudia , Juárez‐Villegas Luis , Pérez‐Cuevas Ricardo 
Published: July 2020

AbstractBackgroundThe objective was to investigate factors associated with patient‐related timing (PRT) to seek healthcare and health service–related timing (HSRT) to diagnose cancer and provide treatment to children without social security in Mexico.ProcedureA cross‐sectional survey was conducted in 13 Ministry of Health hospitals in the states of Chihuahua, Jalisco, Mexico City, Morelos, Oaxaca, Puebla, Queretaro, State of Mexico, and Tlaxcala. Study participants were parents of recently diagnosed pediatric cancer patients (≤ 17 years of age). Three groups of factors were investigated: (1) patients (child and parent characteristics); (2) healthcare providers (HCPs) (first‐contact HCP, institution, perceptions of barriers to healthcare, etc.); and (3) disease factors (cancer type/site, stage/risk at diagnosis). PRT and HSRT‐associated factors were identified using multiple negative binomial regressions.ResultsThe study included 265 children; 49% sought care when symptoms first appeared. The median PRT was seven days, and the median HSRT was 40 days. Parents’ perceptions of long wait times for appointments were associated with longer PRT and HSRT. Residing in the lowest or highest socioeconomic regions and persistent or worsening symptoms increased the probability of longer PRT. Older patient age, HCP requests for imaging tests or prescription for steroids, a higher number of doctors consulted, having a urinary tract cancer, and having an advanced stage or high‐risk cancer increased the probability of longer HSRT.ConclusionStrategies to shorten lag time from symptom onset to diagnosis and treatment are urgently needed for childhood cancers in Mexico.
Genome‐wide and structural analyses of pseudokinases encoded in the genome of Arabidopsis thaliana provide functional insights
Authors: Paul Anindita , Srinivasan Narayanaswamy 
Published: July 2020

AbstractProtein Kinase‐Like Non‐Kinases (PKLNKs), commonly known as “pseudokinases”, are homologous to eukaryotic Ser/Thr/Tyr protein kinases (PKs) but lack the crucial aspartate residue in the catalytic loop, indispensable for phosphotransferase activity. Therefore, they are predicted to be “catalytically inactive” enzyme homologs. Analysis of protein‐kinase like sequences from Arabidopsis thaliana led to the identification of more than 120 pseudokinases lacking catalytic aspartate, majority of which are closely related to the plant‐specific receptor‐like kinase family. These pseudokinases engage in different biological processes, enabled by their diverse domain architectures and specific subcellular localizations. Structural comparison of pseudokinases with active and inactive conformations of canonical PKs, belonging to both plant and animal origin, revealed unique structural differences. The currently available crystal structures of pseudokinases show that the loop topologically equivalent to activation segment of PKs adopts a distinct‐folded conformation, packing against the pseudoenzyme core, in contrast to the extended and inhibitory geometries observed for active and inactive states, respectively, of catalytic PKs. Salt‐bridge between ATP‐binding Lys and DFG‐Asp as well as hydrophobic interactions between the conserved nonpolar residue C‐terminal to the equivalent DFG motif and nonpolar residues in C‐helix mediate such a conformation in pseudokinases. This results in enhanced solvent accessibility of the pseudocatalytic loop in pseudokinases that can possibly serve as an interacting surface while associating with other proteins. Specifically, our analysis identified several residues that may be involved in pseudokinase regulation and hints at the repurposing of pseudocatalytic residues to achieve mechanistic control over noncatalytic functions of pseudoenzymes.
Multiple patchy pulmonary consolidation in granulomatosis with polyangiitis
Authors: Yamasaki Masahiro , Taniwaki Masaya , Nakano Shota , Matsumoto Naoko , Nabeshima Shinji , Hattori Noboru 
Published: July 2020

Key messageMultiple patchy pulmonary consolidations that are unresponsive to antibiotics and/or exist at peri‐bronchial sites and bloody bronchoalveolar lavage may effectively help clinicians diagnose granulomatosis with polyangiitis.
Data‐driven fault detection for linear systems: A q‐step residual iteration approach
Authors: Wang Xiao‐Lei , Yang Guang‐Hong , Zhang Dianhua 
Published: July 2020

SummaryThis article studies the problem of data‐driven (DD) fault detection (FD) for linear systems. First, based on the DD realization of kernel representation, new residual generators are designed via a q‐step residual iteration method. Then, it is proved that the proposed residual generators guarantee the stability and L1 performance of the FD error systems, and the presented residual design method is more sensitive to faults than the existing ones constructed directly from available process data. Finally, two simulation examples are provided to verify the effectiveness and advantages of the designed method.
Robust fault estimation of discrete‐time nonlinear plants via a comprehensive partition‐based switching scheme
Authors: Xie Xiangpeng , Zang Bipeng , Yue Dong , Chadli Mohammed 
Published: July 2020

SummaryThe problem of robust fault estimation (FE) for a class of nonlinear systems in discrete‐time domain is studied via proposing a comprehensive partition‐based switching scheme. Both enhancement factors and attenuation factors are designed synchronously for accomplishing a comprehensive partition of the entire space spanned by the considered normalized fuzzy weighting functions. Thanks to the proposed comprehensive partition‐based switching scheme, six subspaces would be obtained by identifying the real‐time permutation order of the underlying parameters. Therefore, a novel fuzzy FE observer with six kinds of switching modes can be on‐line implemented. As a result, the robust H∞ performance index can be enhanced since much more information is employed than those reported results. Finally, simulation comparisons over the existing results are provided to show the obtained advantages of the article.
Glean lessons learned from foster care support programs to help students succeed after pandemic‐related trauma
Authors: Hilton Warren , Mangold Susan , Generose Nicole , Suriel Joanna 
Published: July 2020

The COVID‐19 pandemic upended the sense of community many college students relied upon. When in‐person classes and events were suspended, feelings of anxiety and loss swelled among the student population. It's no surprise that some students needed more than just refunds for housing, meal plans, and other fees.
Wafer‐Like CoS Architectures and Their Nanocomposites with Polypyrrole for Electrochemical Energy Storage Applications
Authors: Ashraf Nabeela , Aadil Muhammad , Zulfiqar Sonia , Sabeeh Humera , Khan Muhammad Azhar , Shakir Imran , Agboola Philips O , Warsi Muhammad Farooq 
Published: July 2020

AbstractIn this work, we have fabricated wafer‐like CoS and their nanocomposite with Polypyrrole (PPy) via hydrothermal and ultra‐sonication techniques. The fabrication of the nanocomposite was confirmed by XRD and FT‐IR analysis. The morphology and elemental composition of the as‐prepared CoS and their nanocomposite with PPy was investigated by FESEM and EDX analysis. The synthesized CoS/PPy nanocomposite (NCs) exhibit higher gravimetric capacitance (564 Fg−1 at 1 Ag−1) and superior cycling durability with 87.6% retention after 1000 charges/discharge cycles compared to CoS wafers, thus exhibiting as a pure pseudocapacitive electrode. The superior capacitive performance of the CoS/PPy NCs is due to wafer‐like CoS and highly conductive matrix of PPy. The porous structure of the CoS provides more sites for redox reactions, while the PPy matrix facilitates the transportation of charges via their conductive channels. Hence PPy in NCs plays a double role, one as a pseudocapacitive supplement while second as a highly conductive matrix. The fabricated CoS/PPy NCs exhibits lower electrical resistivity (2.5 × 103 Ω‐cm) than that of pristine CoS NWs (3.4 × 107 Ω‐cm), due to the presence of highly conductive matrix of PPy. The improved electrical conductivity of the CoS/PPy NCs (2.5 × 103 Ω‐cm) than the wafer‐like CoS (3.4 × 107 Ω‐cm) was confirmed by I−V measurements. Moreover, the lower charge transfer resistance (Rct, 22 Ω) of the CoS/PPy NCs during the EIS test also indicates its superior redox activity. The results of electrical and electrochemical tests show that CoS/PPy NCs can be used as a potential electrode material for higher performance pseudocapacitor applications.
Conformational Relative Stability and Thermal Properties of Succinonitrile in Gas and Condensed Phases: Using CCSD and DFT Calculations
Authors: Alomari Mohammed I. 
Published: July 2020

AbstractThe geometry and relative stability of succinonitrile in the gas phase have been studied using DFT and ab initio calculations. The trans 1(A) and gauche 1(B) conformers found in succinonitrile are stemmed from the different positions of the two nitrile groups relative to each other. Our results suggest that the trans conformer is more stable than the gauche geometry by 0.65 and 1.01 kcal/mol using the CCSD/6‐311G+(d) and M06/ aug‐cc‐pVDZ calculations, respectively. The results from population analysis indicate that the gas phase is 64.4 % abundant of trans conformer. To imitate the crystal phase, unit cells containing four succinonitrile molecules have been optimized. The data suggest that the trans molar volume of the condensed phase 5(A, B) is smaller than the gauche form 4(A, B, C) by ∼50 Å3 per unit cell. Therefore, at extremely high pressures of up to about 2.9 GPa, the trans conformer predominates. On the contrary, the gauche conformer becomes the predominant isomer as the temperature of the system decreases. This is attributed to the higher stability exhibited by the gauche conformer unit cells compared to that of the trans conformer.
Synthesis of Magnetic Silk Nanostructures with Peroxidase‐Like Activity as an Approach for the Detection of Glucose
Authors: Mousavizadegan Maryam , Azimzadeh Asiabi Pegah , Hosseini Morteza , Khoobi Mehdi 
Published: July 2020

AbstractNanozymes have fascinated increasing attention in the field of enzyme based detection methods. In this study, we have focused on developing a rapid, colorimetric sensing method using peroxidase mimicking nanostructures for the visual detection of glucose molecules in biological samples. For this, using Fe3O4 and silk fibroin proteins, magnetic silk nanostructures (MSF nanostructures) were specifically tailored. Given their ability of catalyzing the oxidation of 3,3′,5,5′‐tetramethylbenzidine (TMB) in the presence of hydrogen peroxide, they can be used as colorimetric catalysts in the detection of glucose based on the production of H2O2. Using MSF nanostructures, glucose molecules were detected by both the naked eye and UV‐Vis spectrophotometry in concentrations ranging from 1.4 to 86.0 μM, with a detection limit of 0.5 μM and a good linear relationship (R2=0.988). In conclusion, it can be stated that the proposed nanostructure holds great potential for biosensing applications.
“The Canary in the Coal Mine…” A cautionary tale from the decline of SourceForge
Authors: Tamburri Damian Andrew , Blincoe Kelly , Palomba Fabio , Kazman Rick 
Published: July 2020

SummaryForges are online collaborative platforms to support the development of distributed open source software. While once mighty keepers of open source vitality, software forges are rapidly becoming less and less relevant. For example, of the top 10 forges in 2011, only one survives today—SourceForge—the biggest of them all, but its numbers are dropping and its community is tenuous at best. Through mixed‐methods research, this article chronicles and analyze the software practice and experiences of the project's history—in particular its architectural and community/organizational decisions. We discovered a number of suboptimal social and architectural decisions and circumstances that, may have led to SourceForge's demise. In addition, we found evidence suggesting that the impact of such decisions could have been monitored, reduced, and possibly avoided altogether. The use of sociotechnical insights needs to become a basic set of design and software/organization monitoring principles that tell a cautionary tale on what to measure and what not to do in the context of large‐scale software forge and community design and management.
Self‐centering steel–timber hybrid shear wall with slip friction dampers: Theoretical analysis and experimental investigation
Authors: Cui Ye , Shu Zhan , Zhou Ruirui , Li Zheng , Chen Fei , Ma Zhong 
Published: July 2020

SummaryAn innovative self‐centering steel–timber hybrid shear wall (SC‐STHSW) system is proposed as a promising structural solution for earthquake‐resilient buildings. The SC‐STHSW is composed of posttensioned (PT) steel rocking frame and infill light‐frame wood shear wall. The PT steel frame provides self‐centering capability, whereas the infill wood shear wall improves the lateral stiffness and the load resistance. Meanwhile, friction dampers are assembled into the connections between the steel frame and the infill wall to provide energy dissipation. Theoretical analysis and cyclic loading test were conducted to comprehend the load‐resisting behavior of the proposed SC‐STHSW system, and closed‐form solutions of the moment, shear, and axial force distribution along the length of the steel beam were formulated. Moreover, a nonlinear finite element model was developed, and the model was further used to verify the derived theoretical formulas. Results showed that the SC‐STHSW system was able to undergo large interstory drift without the development of plastic zones in the steel frame members, which resulted in very small residual deformation. The presented experimental and numerical results aim to provide a practical structural solution for high‐performance earthquake‐resilient buildings.
Cytotoxicity of naringenin induces Bax‐mediated mitochondrial apoptosis in human lung adenocarcinoma A549 cells
Authors: Lu Win‐Long , Yu Chang‐Tze Ricky , Lien Hsiu‐Man , Sheu Gwo‐Tarng , Cherng Shur‐Hueih 
Published: July 2020

AbstractNaringenin (NGEN), a natural flavonoid has growth inhibition and apoptosis‐inducing activities in several cancer cells. However, the cytotoxicity mechanisms of NGEN in cell death of lung cancer cells have not been fully defined. In present study, treatment of human lung adenocarcinoma A549 cells with NGEN resulted in time‐ and dose‐dependent decreases in cell viability. Moreover, NGEN significantly induced apoptosis evidenced by morphological changes, DAPI staining, TUNEL assay and sub‐G1 population increase. In NGEN‐treated cells, intensely upregulated Bax and down‐regulated Bcl‐2 proteins were detected and the Bax protein associated with the mitochondrial membrane was analyzed by subcellular fractionation. Knockdown of the Bax expression by the shRNA method dramatically protected A549 cells against NGEN‐induced apoptosis. Treatment with the inhibitors of caspase‐3, ‐8, or ‐9 significantly reduced NGEN‐induced apoptotic deaths. Taken together, our results demonstrate that NGEN‐induced apoptosis may occur via a Bax‐activated mitochondrial pathway in lung adenocarcinoma A549 cells.
Effective Pronghorn Translocation Methodology: A Long‐Term Summary
Authors: Gann Whitney J. , Gray Shawn S. , Dittmar Robert O. , Gonzalez Carlos E. , Harveson Louis A. 
Published: July 2020

ABSTRACTPronghorn (Antilocapra americana) populations in North America were once estimated at nearly 30 million. However, unrestricted harvest of pronghorn was one of the major factors that led to 25,000 individuals by 1924. Through rigorous management, pronghorn populations rebounded to an estimated 1 million individuals by 1984. Within Texas, USA, by the late 1980s, the pronghorn population had recovered to a new estimated historic high of 17,226 individuals through restoration efforts. However, by 2010, the Texas Trans‐Pecos population declined to approximately 4,700 individuals, and declined even further to only 2,751 in 2012. A main contribution to successful recovery has been large‐scale translocations. Since the early 1920s, >30,000 pronghorn have been translocated in 17 states. As one large restoration project in Texas, translocation of pronghorn from the Texas Panhandle to Marfa and Marathon grasslands in the Trans‐Pecos region occurred in January–February 2011, 2013, 2014, 2016, and 2017. However, within the available literature on pronghorn translocations, it was difficult to find a scientific paper that provides sufficient detail to guide the translocation process. Our intent is to summarize the effective methodology behind 5 years of pronghorn translocations, inform others to make evidence‐based recommendations and justifiable‐decisions when selecting translocation methodology, and provide insight regarding design and application of our translocation methodology. Based on our translocation experience, we recommend using halperidol as a sedative given to pronghorn at the site of capture and keeping handling times to ≤4 minutes as well as maintaining pronghorn body temperatures below 40° C during processing. Flunixin meglumine should be used when body temperatures exceed 40° C. In addition, we also recommend utilizing larger, more spacious livestock trailers to transport captured pronghorn versus transport boxes or smaller, more enclosed trailers. We also recommend releasing a minimum of 50–100 individuals/release site to minimize stress from group separation and improve long‐term population sustainability. © 2020 The Wildlife Society.
Developing an Interactive Tabletop Mediated Activity to Induce Collaboration by Implementing Design Considerations Based on Cooperative Learning Principles
Authors: Sunnen Patrick , Arend Béatrice , Heuser Svenja , Afkari Hoorieh , Maquil Valérie 
Published: July 2020

Abstract
Constructive collaboration can be a difficult matter. For this reason, we are implementing and studying an interactive-tabletop-mediated activity that aims at inducing collaboration among participants. The resulting activity ‘Orbitia’ is designed as a serious game. Participants are asked to act as a space-mining crew, which has to collect minerals with a rover and rely on a camera-drone for reconnaissance, while keeping the rover out of harm and managing limited resources. In this paper we provide an account of how we designed Orbitia’s pedagogical structuring by relying on the Johnsons’ cooperative learning approach whose fundamental concept is “positive interdependence”. More particularly, we show how we worked on resource, role and task interdependence to design three collaboration-inducing ‘flagship’ devices: the rover-steering-device (RSD), the item-locating-device (ILD) and the responsibility-activating-device (RAD).