bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence, risk factors, and prognostic indicators of symptomatic air embolism after percutaneous transthoracic lung biopsy: a systematic review and pooled analysis
Authors: Lee Jong Hyuk , Yoon Soon Ho , Hong Hyunsook , Rho Ji Young , Goo Jin Mo 
Published: October 2020

AbstractObjectivesTo determine the incidence, risk factors, and prognostic indicators of symptomatic air embolism after percutaneous transthoracic lung biopsy (PTLB) by conducting a systematic review and pooled analysis.MethodsWe searched the EMBASE and OVID-MEDLINE databases to identify studies that dealt with air embolism after PTLB and had extractable outcomes. The incidence of air embolism was pooled using a random effects model, and the causes of heterogeneity were investigated. To analyze risk factors for symptomatic embolism and unfavorable outcomes, multivariate logistic regression analysis was performed.ResultsThe pooled incidence of symptomatic air embolism after PTLB was 0.08% (95% confidence interval [CI], 0.048–0.128%;I2 = 45%). In the subgroup analysis and meta-regression, guidance modality and study size were found to explain the heterogeneity. Of the patients with symptomatic air embolism, 32.7% had unfavorable outcomes. The presence of an underlying disease (odds ratio [OR], 5.939; 95% CI, 1.029–34.279;p = 0.046), the use of a ≥ 19-gauge needle (OR, 10.046; 95% CI, 1.103–91.469;p = 0.041), and coronary or intracranial air embolism (OR, 19.871; 95% CI, 2.725–14.925;p = 0.003) were independent risk factors for symptomatic embolism. Unfavorable outcomes were independently associated with the use of aspiration biopsy rather than core biopsy (OR, 3.302; 95% CI, 1.149–9.492;p = 0.027) and location of the air embolism in the coronary arteries or intracranial spaces (OR = 5.173; 95% CI = 1.309–20.447;p = 0.019).ConclusionThe pooled incidence of symptomatic air embolism after PTLB was 0.08%, and one-third of cases had sequelae or died. Identifying whether coronary or intracranial emboli exist is crucial in suspected cases of air embolism after PTLB.Key Points•The pooled incidence of symptomatic air embolism after percutaneous transthoracic lung biopsy was 0.08%, and one-third of patients with symptomatic air embolism had sequelae or died.•The risk factors for symptomatic air embolism were the presence of an underlying disease, the use of a ≥ 19-gauge needle, and coronary or intracranial air embolism.•Sequelae and death in patients with symptomatic air embolism were associated with the use of aspiration biopsy and coronary or intracranial locations of the air embolism.
Flexible endoscopy is enough diagnostic prior to loop ileostomy reversal
Authors: Lindner S. , von Rudno K. , Gawlitza J. , Hardt J. , Sandra-Petrescu F. , Seyfried S. , Kienle P. , Reissfelder C. , Bogner A. , Herrle F. 
Published: October 2020

Abstract
Purpose
This study investigates whether contrast enema (CE) and flexible endoscopy (FE) should be performed routinely after low anterior resection (LAR) before ileostomy reversal. Additionally, the impact of previous anastomotic leakage (AL) on diagnostic test accuracy (DTA) was assessed.

Methods
This is a retrospective analysis of prospectively collected tertiary care data of two centers. Consecutive rectal cancer patients undergoing LAR with loop ileostomy formation were included. Before ileostomy reversal, all patients were assessed by CE and FE. DTA of FE and CE for asymptomatic AL in patients who had previously suffered from clinically relevant AL (group 1) compared with those without apparent AL after LAR (group 0) were assessed separately.

Results
Two hundred ninety-three patients were included in the analysis, 86 in group 1 and 207 in group 0. Overall sensitivity for detection of asymptomatic AL was 76% (FE) and 60% (CE). Specificity was 100% for both tests. DTA of FE was equal or superior to CE in all subgroups. Prevalence of asymptomatic AL at the time of testing was 1.4% in group 0 and 25.6% in group 1.

Conclusion
Flexible endoscopy is the more accurate diagnostic test for the detection of asymptomatic anastomotic leaks prior to ileostomy reversal. Contrast enema showed no gain of information. In the group without complications after the initial rectal resection, 104 must be tested to find one leak prior to reversal. In those patients, routine diagnostic testing additional to digital rectal examination may be questioned.
An overview of viral infections of the nervous system in the immunosuppressed
Authors: Kennedy Peter G. E. 
Published: October 2020

AbstractSeveral viruses have the capacity to cause serious infections of the nervous system in patients who are immunosuppressed. Individuals may be immunosuppressed because of primary inherited immunodeficiency, secondary immunodeficiency due to particular diseases such as malignancy, administration of immunosuppressant drugs or organ or bone marrow transplantation. The viruses capable of such opportunistic infection of the nervous system include herpes simplex virus (HSV), Varicella-Zoster virus (VZV), Cytomegalovirus (CMV), Epstein –Barr virus (EBV), Human Herpes virus type 6 (HHV-6), JC virus (JCV), enterovirus, measles virus and Covid-19. In most cases it seems likely that immunological defence mechanisms in the immunosuppressed are deficient which creates a suitable environment for certain viruses to become opportunistic in the nervous and other systems. Further research is required both to understand these opportunistic mechanisms in more detail and also to determine how many virus infections are modified by specific inborn errors of immunological responses.
Short-term choroidal vascular changes after aflibercept therapy for neovascular age-related macular degeneration
Authors: Pellegrini Marco , Bernabei Federico , Mercanti Andrea , Sebastiani Stefano , Peiretti Enrico , Iovino Claudio , Casini Giamberto , Loiudice Pasquale , Scorcia Vincenzo , Giannaccare Giuseppe 
Published: October 2020

Abstract
Introduction
The purpose of this study was to evaluate choroidal vascular changes in patients with neovascular age-related macular degeneration (nAMD) treated with aflibercept injection over a 3-month period.

Methods
Enhanced depth imaging optical coherence tomography scans of 60 eyes with treatment-naïve nAMD and 60 unaffected fellow eyes were retrospectively analyzed. Data was collected at baseline and after 3 monthly intravitreal injections of aflibercept. The ImageJ software was used to binarize OCT scans and measure total choroid area (TCA), luminal area (LA), and stromal area (SA). Choroidal vascularity index (CVI) was defined as the ratio of LA to TCA.

Results
After treatment, subfoveal choroidal thickness (CT) in nAMD eyes significantly decreased from 210. 6 ± 61.6 to 194.6 ± 58.7 μm (P < 0.001), TCA from 1.620 ± 0.502 to 1.500 ± 0.451 mm2 (P < 0.001), LA from 1.075 ± 0.335 to 0.985 ± 0.307 mm2 (P < 0.001), SA from 0.545 ± 0.176 to 0.516 ± 0.153 mm2 (P = 0.005), and CVI from 66.36 ± 2.89 to 65.46 ± 2.87% (P = 0.009). The decrease of CVI after treatment was significantly correlated with baseline CVI (Rs = 0.466, P < 0.001), but not with the change in BCVA and presence of dry macula after treatment (always P > 0.05).

Conclusion
Choroidal thickness and vascularity significantly decreased after treatment with aflibercept in nAMD eyes. Besides the pharmacologic effect on the neovascular lesion, aflibercept may induce vascular changes also on the underlying choroid.
Suspected autochthonous Thelazia callipaeda infection in a dog in northern Germany
Authors: Lebedewa Sophia L. , Tkocz Kevin , Clausen Peter-Henning , Nijhof Ard M. 
Published: October 2020

AbstractA 12-year old Elo dog was presented with recurring symptoms of conjunctivitis in November 2019. A single whitish nematode was found upon inspection of the eye and identified as a Thelazia callipaeda male. The morphological identification of the eye worm was supported by analysis of a partial cytochrome c oxidase I (cox1) gene sequence. The dog lived in Lower Saxony, northwestern Germany, and had not visited regions known to be endemic for T. callipaeda. This suggests that a local transmission cycle of this zoonotic nematode may exist in Germany.
Measurement of outflow resistance imposed by magnetic sphincter augmentation: defining normal values and clinical implication
Authors: Ayazi Shahin , Grubic Andrew D. , Zheng Ping , Zaidi Ali H. , Schwameis Katrin , Alleyne Adam C. , Myers Brittney M. , Omstead Ashten N. , Jobe Blair A. 
Published: October 2020

Abstract
Introduction
No manometric criteria have been defined to select patients for magnetic sphincter augmentation (MSA). The first step to establish such criteria is to measure the outflow resistance at esophagogastric junction (EGJ) imposed by MSA. This resistance needs to be overcome by the esophageal contraction in order for the esophagus to empty and to avoid postoperative dysphagia. This study was designed to measure the outflow resistance caused by MSA in patients free of postoperative dysphagia.

Methods
Records of the patients who underwent MSA in our institution were reviewed. A group of MSA patients with excellent functional outcome, who were free of clinically significant postoperative dysphagia, were selected. These patients then underwent high-resolution impedance manometry (HRIM) at a target date of 1 year after surgery. The outflow resistance was measured by the esophageal intrabolus pressure (iBP) recorded 2 cm proximal to the lower esophageal sphincter (LES).

Results
The study population consisted of 43 patients. HRIM was performed at mean of 20.4 (10.4) months after surgery. The mean (SD) amplitude of the iBP was 13.5 (4.3) before surgery and increased to 19.1 (5.6) after MSA (p < 0.0001). Patients with a smaller size LINX device (≤ 14 beads) had a similar iBP when compared to those with a larger device (> 15 beads) [19.7 (4.5) vs. 18.4 (5.9), p = 0.35]. There was a significant correlation between the iBP and % incomplete bolus clearance [Spearman R: 0.44 (95% CI 0.15–0.66), p = 0.0032]. The 95th percentile value for iBP after MSA was 30.4 mmHg.

Conclusion
The EGJ outflow resistance measured by iBP is increased after MSA. The upper limit of normal for iBP is 30 mmHg in this cohort of patients who were free of dysphagia after MSA. This degree of resistance needs to be overcome by distal esophageal contraction and will likely be requisite to prevent persistent postoperative dysphagia.
Artificial intelligence facilitates decision-making in the treatment of lumbar disc herniations
Authors: Wirries André , Geiger Florian , Hammad Ahmed , Oberkircher Ludwig , Blümcke Ingmar , Jabari Samir 
Published: October 2020

Abstract
Purpose
Apart from patients with severe neurological deficits, it is not clear whether surgical or conservative treatment of lumbar disc herniations is superior for the individual patient. We investigated whether deep learning techniques can predict the outcome of patients with lumbar disc herniation after 6 months of treatment.

Methods
The data of 60 patients were used to train and test a deep learning algorithm with the aim to achieve an accurate prediction of the ODI 6 months after surgery or the start of conservative therapy. We developed an algorithm that predicts the ODI of 6 randomly selected test patients in tenfold cross-validation.

Results
A 100% accurate prediction of an ODI range could be achieved by dividing the ODI scale into 12% sections. A maximum absolute difference of only 3.4% between individually predicted and actual ODI after 6 months of a given therapy was achieved with our most powerful model. The application of artificial intelligence as shown in this work also allowed to compare the actual patient values after 6 months with the prediction for the alternative therapy, showing deviations up to 18.8%.

Conclusion
Deep learning in the supervised form applied here can identify patients at an early stage who would benefit from conservative therapy, and on the contrary avoid painful and unnecessary delays for patients who would profit from surgical therapy. In addition, this approach can be used in many other areas of medicine as an effective tool for decision-making when choosing between opposing treatment options, despite small patient groups.
Sensitivity of Canopy Phenology to Local Urban Environmental Characteristics in a Tropical City
Authors: Kabano Peter , Harris Angela , Lindley Sarah 
Published: October 2020

AbstractCanopy phenology is sensitive to variability in local environmental settings. In temperate climates, urban phenological processes and their determinants are relatively well understood. Equivalent understanding of processes in tropical urban settings is, however, less resolved. In this paper, we explore the influence of local urban environmental characteristics (that is, degree of urbanization, land cover and urban climate) on canopy phenology of two deciduous tree species (Jacaranda mimosifolia, n = 48, and Tabebuia rosea, n = 24) in a tropical city (Kampala, Uganda). Our study design involved ground monitoring and field sampling in 2017, with a focus on the dry season. We found that both species experienced significantly higher rates of canopy cover decline in heavily built-up neighborhoods (p < 0.05 for both species). Moreover, Jacaranda was more sensitive to differences in the degree of urbanization than Tabebuia, both in terms of total percentage tree canopy cover (p < 0.01) and net leaf loss (p < 0.05). Total percentage tree canopy cover for Jacaranda declined with increasing proportion of impervious cover (that is, roads and paved cover) and was positively related to relative humidity (p < 0.01), a variable correlated with soil moisture. Net leaf loss in Jacaranda increased with the decreasing proportion of pervious land cover and as nighttime air temperature increased (p < 0.01). In contrast, land cover and urban climate had no significant influence on either measure of phenological traits for Tabebuia. These results provide new evidence of the effect of urbanization on canopy phenology of different tree species in the tropics. Such knowledge offers new insights into the spatial and temporal differences in the physiological functional traits of trees and also serves as a proxy for possible species responses under future climate change.
CACNA1B gene variants in adult-onset isolated focal dystonia
Authors: Cocoș Relu , Raicu Florina , Băjenaru Ovidiu Lucian , Olaru Iulia , Dumitrescu Laura , Popescu Bogdan Ovidiu 
Published: October 2020

Abstract
Background
Isolated focal dystonia (IFD) is a heterogeneous group of potentially invalidating movement disorders. The etiopathogenesis is complex, both genetic and environmental factors playing a role, but remains elusive. The CACNA1B gene codes for the N-type neuronal voltage-gated calcium channels CaV2.2, which may play a role in the development of some IFD.

Methods
We analyzed samples from the GENDYS cohort for mutations in CACNA1B gene, using targeted next-generation sequencing (NGS).

Results
The GENDYS cohort consists of 120 people with adult-onset IFD (cervical dystonia 47.5%, blepharospasm 47.2%, others 8.3%). Of these, 35% had subsequent topographical extension. Average age at onset was 42 and average disease durations 8 years. Targeted NGS revealed a novel frameshift mutation c.2291AGG > A, in exon 19, and a previously reported variant, c.6834T > G, in exon 47.

Conclusion
Our findings suggest that disease-causing mutations in CACNA1B gene may be involved in the development of some adult-onset IFD. To our knowledge, this is the first study that identified a disease-causing CACNA1B gene mutation in association with adult-onset IFD.
Why Dutch officials take bribes: a toxic mix of factors
Authors: Gorsira Madelijne , Huisman Wim , Denkers Adriaan , Steg Linda 
Published: October 2020

AbstractThe aim of this study was to gain an in-depth understanding of the factors that underlie public officials’ engagement in corruption. Given the significant public interest, we gained permission from the Dutch Ministry of Justice to analyze multiple confidential criminal files of cases in which Dutch public officials took bribes from private companies. Extending previous research, we analyzed three types of factors, individual factors, organizational factors, and factors related to the relationships between corrupt officials and their bribers. Moreover, for the first time, we considered the interplay between these three types of factors. The results suggest that public officials’ engagement in bribery is rooted in a combination of individual, organizational and relationship variables that influence and reinforce each other, creating a toxic mix. This implies that the battle against bribery can be fought on multiple fronts, whereby changing one critical factor may cause the mix to lose its toxicity.
Technology teacher’s perceptions of model functions in technology education
Authors: Citrohn Björn , Svensson Maria 
Published: October 2020

AbstractIn this study we investigate how 11 Swedish technology teachers perceive model functions in technology education. The main reason for investigating model functions in technology is an identified lack of knowledge about, and research studies into, a conscious use of models when teaching technology, even though models are part of technology education in many countries. In order to answer the research question of how technology teachers perceive model functions in technology education, we have used directed content analysis where Nia and de Vries (J Technol Des Educ 27:627–653, 2017) model functions constituted a framework. The teachers connect model functions to two teaching contexts: Design process and Explain and facilitate understanding of technological solutions. Model functions are understood as parts of the design process which relate to technology/engineering knowledge, a prescriptive way of understanding models. Models are also used to explain and clarify specific technological situations or functions when teaching technology closely related to a scientific, descriptive way of using models. Five of Nia and de Vries model functions are identified in this empirical study. This strengthens the importance of addressing model functions in technological education.
An evaluation of selected chemical, biochemical, and biological parameters of soil enriched with vermicompost
Authors: Przemieniecki Sebastian Wojciech , Zapałowska Anita , Skwiercz Andrzej , Damszel Marta , Telesiński Arkadiusz , Sierota Zbigniew , Gorczyca Anna 
Published: October 2020

AbstractThe aim of this study was to assess the changes in chemical and microbial properties and enzymatic activity of soil enriched with vermicompost derived from household waste. The vermicompost was tested in the rhizosphere of Larix decidua seedlings cultivated in 10-L pots in: (i) nursery soil (as the control), (ii) soil with 10% v/v vermicompost, and (iii) with 20% v/v vermicompost. The impact of vermicompost was assessed in terms of soil C/N ratio; bacterial, fungal, and nematode counts; and enzymatic activity. It was found that vermicompost increased the C/N ratio from 21 to 32, as well as the content of nitrate from 78 to 134 mg kg−1, of ammonium from 14 to 139 mg kg−1, of phosphorus from 92 to 521 mg kg−1, and of potassium from 142 to 1912 mg kg−1, compared with the control soil. The abundance of beneficial bacteria was increased (from 8.61 × 107 to 37.9 × 107), along with decreases in microbiological ratios of fungi and bacteria (e.g. fungi/Bacillus from 0.18818 to 0.00425). A significant 2- to 4-fold increase was observed compared with the control in the number of beneficial nematodes belonging to bacterivorous, fungivorous, and predatory groups with no change in the abundance of plant-parasitic nematodes. Addition of vermicompost brought about a change in soil enzyme activity. Vermicompost reduced the activity of alkaline phosphatase only. Both doses of vermicompost led to an increase in the activity of acid phosphatase, inorganic pyrophosphatase, dehydrogenases, β-glucosidase, and urease. Only the higher dose had an effect on increasing the activity of o-diphenol oxidase and proteases. No significant change was observed for nitrate reductase. Also, the presence of antibiotics produced by bacteria was detected depending on the dose of vermicompost, e.g. iturin (ituC) and bacillomycin (bmyB) were found in soil with a dose of 20% v/v vermicompost. Overall, vermicompost produced from household waste can be an excellent organic fertilizer for larch forest nurseries.
Do Animals Feel Pain in a Morally Relevant Sense?
Authors: Miller Calum 
Published: October 2020

AbstractThe thesis that animals feel a morally relevant kind of pain is an incredibly popular one, but explaining the evidence for this belief is surprisingly challenging. Michael Murray has defended neo-Cartesianism, the view that animals may lack the ability to feel pain in a morally relevant sense. In this paper, I present the reasons for doubting that animals feel morally relevant pain. I then respond to critics of Murray’s position, arguing that the evidence proposed more recently is still largely unpersuasive. I end by considering the implications for moral discourse and praxis.
Antidepressant prescriptions and associated factors in men with prostate cancer and their female partners
Authors: Hartung Tim J. , Moustsen Ida Rask , Larsen Signe Benzon , Wreford Andersen Elisabeth A. , Suppli Nis P. , Johansen Christoffer , Tjønneland Anne , Friberg Anne S. , Kjær Susanne K. , Brasso Klaus , Kessing Lars V. , Mehnert Anja , Dalton Susanne Oksbjerg 
Published: October 2020

AbstractPurposeTo estimate the risk of first-time antidepressant prescriptions as a proxy for depression or anxiety and associated risk factors in patients with prostate cancer and their female partners.MethodsWe followed all men (n = 25,126) and their female cohabiting partners (n = 8785) without a history of cancer or antidepressants from the Danish Diet, Cancer and Health cohort from 1997 to 2014 or 2010, respectively. We estimated the cumulative incidence of first-time antidepressant prescriptions in men with prostate cancer compared with cancer-free men and their respective female partners, using the Danish National Prescription Registry. Sociodemographic, lifestyle-related, and clinical risk factors were assessed using Cox regression models.ResultsA total of 1828 men were diagnosed with prostate cancer of whom 15% received antidepressants. The unadjusted hazard ratio of antidepressant prescription was 2.18 (95%CI, 1.92, 2.48) for men with prostate cancer and 1.27 (95%CI, 0.87, 1.85) for their partners, compared with cancer-free men and their partners, respectively. After adjusting for sociodemographic, lifestyle-related, and comorbidity factors, this risk was 2-fold to 4-fold increased among patients, but not significantly increased among partners. Significant risk factors among patients were curative and palliative treatment (vs. active surveillance and watchful waiting), nonlocalized disease, and short education.ConclusionsMen with prostate cancer have a higher risk of receiving antidepressant medication than cancer-free men. Clinical characteristics can help clinicians in identifying patients at a high risk of depression or anxiety.Implications for Cancer SurvivorsMen with prostate cancer who experience symptoms of depression or anxiety should seek professional help early on. Patient education could aid in raising awareness and reducing the stigma associated with mental disorders.