bluuebunny/crossref_metadata_2025_split huggingface dataset:
P951Autonomic nervous function and excitability of the accessory pathway in pediatric patients with Wolff-Parkinson-White ECG
Authors: Galli A , Lippolis M , Barbolini E , Belmonte M , Ambrosini F , Gherbesi E , Chierchia G B , De Asmundis C , Lombardi F 
Published: June 2020

Abstract
Abrupt loss of preexcitation identifies low-risk Wolff-Parkinson-White (WPW). We hypothesize that the autonomous nervous system (ANS) modulates the conduction of the accessory pathway (AP).
PURPOSE
To compare heart rate variability (HRV) in children with (WPWi) and without (WPWp) intermittent preexcitation.
METHODS
The study conforms to the Declaration of Helsinki.
18 WPW children and controls performed ECG Holter for HRV analysis. Intermittent preexcitation was defined as abrupt loss of WPW pattern. Kolmogorov-Smirnov test confirmed normal distribution of data. T-test and Fisher"s exact test were used for continuous and categorical variables. Multivariate regression excluded the effect of potential confounders (figure 1 shows correlation between HRV and HR).
RESULTS
WPWi (11/18, 61.1%) have higher HRV as compared with WPWp. Despite WPWp patients are younger, with higher HR, corrected multivariate analysis confirmed significant differences (table 1), also between WPW patients and controls.
CONCLUSIONS
WPW patients have lower HRV. WPWp may have worst autonomic control to the excitability of AP.
Table 1 WPW (n = 18)A WPWi (n = 11)B WPWp (n = 7)C Controls (n = 18)D P value A vs. D P value B vs. C P value B vs. D P valueC vs. D Age 7.6 ± 4 10.1 ± 4.2 4.1 ± 2.9 7.8 ± 4.7 0.9 &lt;0.01 0.1 0.03 24 hours mean HR 92.8 ± 15.9 81.1 ± 11.2 104.9 ± 12.6 90.3 ± 16.5 0.7 &lt;0.01 0.03 0.07 pNN50 20 ± 11.4 30.5 ± 11.8 14.7 ± 9.9 24.3 ± 13.4 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 RMSSD 53 ± 19.1 68.8 ± 21.4 44.6 ± 14.7 59.4 ± 22.2 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.01 ASDNN 64.9 ± 21.1 78.4 ± 20.7 48.8 ± 11.8 66.9 ± 22.9 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 SDANN 108.2 ± 39.8 127.9 ± 36 77.5 ± 16.9 108.3 ± 38.8 &lt;0.001 &lt;0.01 &lt;0.001 &lt;0.01 VLF 7.4 ± 0.8 7.8 ± 0.4 6.9 ± 0.5 7.5 ± 0.6 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 LF 6.8 ± 0.8 7.3 ± 0.4 6.4 ± 0.4 6.9 ± 0.6 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 HF 6.6 ± 0.8 7.1 ± 0.7 6.2 ± 0.6 6.7 ± 0.8 &lt;0.001 &lt;0.01 &lt;0.001 &lt;0.01 LF/HF 1.4 ± 0.8 1.4 ± 0.7 1.4 ± 0.6 1.4 ± 0.6 0.2 0.3 0.05 0.7 VarIndex% 4.8 ± 1.4 5.8 ± 1.2 4.4 ± 1.4 5.3 ± 1.4 &lt;0.001 &lt;0.01 &lt;0.01 &lt;0.01 Total Power 8.2 ± 0.7 8.6 ± 0.4 7.8 ± 0.4 8.3 ± 0.6 &lt;0.001 &lt;0.001 &lt;0.001 &lt;0.001 Frequent SVB 2 (11%) 1 (9.1%) 1 (14%) 0 0.5 1.0 0.4 0.3 SVT 1 (5.6%) 1 (9.1%) 0 0 n.a. n.a. n.a. n.a. P values from multivariate analysis and t-test for age and HR. HR: heart rate; WPWi: intermittent preexcitation; WPWp: persistent preexcitation; VarIndex%: variability index (%); SVB: supraventricular beats; SVT: supra ventricular tachycardia. Values are expressed as mean ± SD for age, HR and time domain variables (ms). Variables in the frequency domain are expressed as ln. P &lt;0.05: significant.
Abstract Figure 1
P436The impact of filter settings on morphology of unipolar fibrillation potentials
Authors: Starreveld R , Knops P , Roos-Serote M , Kik C , Bogers A J J C , Brundel B J J M , De Groot N M S 
Published: June 2020

Abstract

Funding Acknowledgements
N.M.S. de Groot, MD, PhD was supported by CVON-AFFIP (914728), NWO-Vidi (91717339) and Biosense Webster USA (ICD 783454).

Background
Using unipolar atrial electrogram morphology as guidance for ablative therapy is regaining interest. Although standardly used in clinical practice during ablative therapy, the impact of filter settings on morphology of unipolar AF potentials is unknown.

Purpose
This study aims to elucidate consequences of high-pass, low-pass and notch filtering on unipolar atrial fibrillation (AF) potentials.

Methods
Thirty different filter settings were applied to high-resolution epicardial AF potentials recorded from ten patients. . Local activation times were determined by marking deflections with slope ≤-0.05mV/ms and amplitude ≥0.3mV. Fibrillation potentials were analyzed for peak-to-peak amplitude (mV), number of deflections (f) and fractionation delay time (FDT, interval between first and last deflection), and classified as single potential (SP, f = 1), double potential (DP, f = 2) or complex fractionated potential (CP, f ≥ 3).

Results
In total, 3000 seconds of AF recordings were analyzed, containing 255,7045 fibrillation potentials. Changing high-pass filtering from 0.5 up to 100 Hz decreased the number of detected fibrillation potentials (with 25-65%), median deflection amplitude (min-max 0.59-0.96 to 0.44-0.57 mV), percentage of DP (25.8-32.9 to 22.5-31.6%) and CP (15.9-36.0 to 7.3-37.8%) as well as median FDT (16-25 to 11-15 ms) (all p &lt; 0.01). Gradually changing low-pass filtering from 400 Hz to 20 Hz induced an exponential decrease in fibrillation potentials (to 0%), percentage of DP (25.8-32.9 to 0%) and CP (15.9-36.0 to 0%), whereas deflection amplitude, percentage of SP and median FDT exponentially increased (0.59-0.96 to 1.82-2.39 mV, 36.1-57.6 to 100%, 16-25 to 33-38 ms, respectively) (all p &lt; 0.01). Notch filtering at 50 Hz decreased the number of detected fibrillation potentials (with ∼1%), median deflection amplitude (0.59-0.96 to 0.59-0.95 mV) (both p &lt; 0.01), whereas the percentage of CP increased (15.9-36.0 to 16.2-37.0%, p = 0.016).

Conclusions
Filtering significantly impacted of unipolar fibrillation potentials and decreased the number of detected potentials, becoming a potential source of error in identification of LATs, low-voltage areas, fractionated potentials and thus ablative targets during mapping.
Potentials (%) Amplitude (mV) SP (%) DP (%) CFP (%) FDT (ms) Default (0.5-400 Hz) 100 0.59-0.96 36.1-57.6 25.8-32.9 15.9-36.0 16.0-25.0 High-pass filtering Decreased Decreased Increased Decreased Decreased Decreased Low-pass filtering Decreased Increased Increased Decreased Decreased Increased Notch filtering Decreased Decreased p = NS p = NS Increased p = NS Impact of filtering on morphology parameters
Abstract Figure. Impact of filtering on AF morphology
40Lateral left ventricular lead position and long interlead electrical delay predict long-term all-cause mortality in cardiac resynchronization therapy patients
Authors: Behon A , Schwertner W R , Merkel E D , Kovacs A , Kutyifa V , Lakatos B , Zima E , Geller L , Kosztin A , Merkely B 
Published: June 2020

Abstract

Background
There is limited data on the association of left ventricular (LV) lead position and long-term clinical outcome in patients after cardiac resynchronization therapy (CRT).

Purpose
We evaluated the mid-term echocardiographic response and long-term all-cause mortality of patients who underwent CRT implantation by LV lead non-apical positions and further characterized them by right to left ventricular, interlead electrical delay (IED).

Methods
In our retrospective registry patients after CRT implantation between 2000 and 2018 were registered. Those with non-apical LV lead location were classified into anterior (n = 111), posterior (n = 652), and lateral (n = 1373) positions. Primary endpoint was all-cause mortality assessed by univariate- and Cox multivariate analyses. Secondary endpoint was echocardiographic response within 6 months after CRT implantation.

Results
From 2136 patients 1180 (55.2%) reached the primary endpoint during the mean follow up time of 4.5 years. Univariate analysis showed patients with lateral position had significantly better outcome compared to others (HR 0.80; 95% CI: 0.71-0.90; p &lt; 0.01), which was also confirmed by Cox multivariate analysis (HR 0.69; 95% CI: 0.50-0.93; p = 0.02) after adjusting for relevant clinical covariates such as IED and LBBB. The median value of IED was 106 (89/124) ms in the total patient cohort, which was significantly longer in the lateral group [anterior 80 (60/100) ms vs. lateral 110 (91/128) ms vs. posterior 100 (85/120) ms; p&lt; 0.01]. When echocardiographic response was further evaluated in patients with lateral position, those with an IED longer than 110 ms (ROC AUC 0.64, 95% CI: 0.54-0.74; p = 0.01) showed the greatest benefit within 6 months.

Conclusions
After CRT implantation the most beneficial outcome was associated with lateral left ventricular lead location, moreover the greatest echocardiographic response was found when interlead electrical delay was longer than 110 ms in this group.
Abstract Figure. All-cause mortality of total cohort
P984Proof of endo-epicardial asynchrony of the left atrial wall in humans
Authors: Kharbanda R , Kik C , Knops P , Bogers A J J C , De Groot N M S 
Published: June 2020

Abstract

Funding Acknowledgements
Prof. Dr. NMS de Groot is supported by funding grants from CVON-AFFIP (914728), NWO-Vidi (91717339), Biosense Webster USA (ICD 783454) and Medical Del

Introduction
Treatment of atrial fibrillation (AF) is still suboptimal as mechanisms underlying AF initiation and persistence are incompletely understood. Endo-Epicardial asynchrony (EEA) plays an important role in AF persistence and has so far only been demonstrated in the right atrium (RA).

Purpose
To investigate whether EEA also exists in the thin walled left atrium (LA) and to measure the maximal degree of EEA between the endo- and epicardial layers during sinus rhythm (SR).

Methods
Simultaneous endo-epicardial mapping of the LA was performed during SR in 3 male patients (73 ± 1.5 years) with history of paroxysmal AF undergoing cardiac surgery including rhythm surgery and LA appendage amputation. Simultaneous endo-epicardial mapping was performed with a mapping clamp containing two electrode arrays of 8x16 electrodes (diameters: 0.4mm, interelectrode distance: 2mm) positioned exactly opposite to each other. The mapping clamp was introduced through the LA appendage with its tip towards the superior pulmonary vein. Local endo-epicardial activation time differences were determined by selecting the median time delay within the exact opposite electrode and its 8 surrounding electrodes. The asynchrony map consisted of the maximum of 2 medians from direct opposite electrodes. EEA was defined as time differences ≥15ms. Conduction delay (CD) and conduction block (CB) were defined as differences in local activation times between neighboring electrodes of respectively ≥7 and ≥12ms.

Results
A total of 35 SR beats were analyzed. Mean total activation time of the whole endo-epicardial LA tissue was 42.4 ± 9.5ms and did not differ between both layers (epicardium: 31.2 ± 9.9ms; endocardium: 37.8 ± 10.3ms; P= 0.62). CD and CB were observed in respectively 3.2% and 6.3% at the epicardium and 3.3% and 3.0% at the endocardium. The lowest amount of CD (5.2%) and CB (0.3%) was observed in the patient who had his first AF episode only 11 days prior to surgery. Also, no EEA was present in this patient. In two patients with paroxysmal AF &gt;6 months, the prevalence of EEA was respectively 2.7% and 41.4% and the degree of EEA ranged from 15 to 44ms. Interestingly, the patient with the highest degree of EEA was diagnosed with paroxysmal AF for almost 5 years (Figure 1).

Conclusion
Our data provides evidence for the existence of EEA in the human left atrium which appears to be already present during SR. Knowledge of EEA and the ability to stage AF based on the degree of EEA is essential for individualized and staged future therapy for AF.
Abstract Figure 1. The maximal degree of endo-epi
42When to implant CRT-P or CRT-D in the elderly?
Authors: Silverio Antonio P , Nunes-Ferreira A , Aguiar-Ricardo I , Rodrigues T , Rigueira J , Santos R , Cunha N , Couto Pereira S , S Morais P , Magalhaes A , Bernardes A , J Pinto F , De Sousa J , Marques P 
Published: June 2020

Abstract

Introduction
Cardiac resynchronization therapy (CRT) in elder patients is increasingly common. However, the decision to implant a device with defibrillator in these patients is often complex and it can be limited not only by the shorter life expectancy but also by a lower relative risk of arrhythmic compare to non-arrhythmic death due to other comorbidities. Thus, wether CRT is effective in an elderly population (≥75 years old), or if a defibrillator (CRT-D versus CRT-P) influences outcomes is a pivotal concern needing additional data.

Purpose
To compare the prognostic impact of CRT-P vs CRT-D in old patients (≥ 75 years old) and its impact in the response rate to CRT.

Methods
A prospective single-center study was conducted of patients indicated for a CRT implant since 2015. Demographic and clinical criteria were evaluated. Transthoracic echocardiography was performed before CRT implant and between 6-12 months post-implant. Patients with an ejection fraction (EF) elevation ≥ 10% or a LV end-systolic volume (ESV) reduction ≥ 15% were classified as responders. Patients with EF elevation ≥ 20% or LV ESV reduction ≥ 30% were classified as super-responders. Time to surgical revision and mortality were evaluated using the Cox regression and Kaplan-Meier methods. The decision to implant a CRT-P or CRT-D device was made according to clinical decision. Prognostic impact of CRT-P vs CRT-D was evaluated by comparing total mortality using the Cox regression and Kaplan-Meier methods.

Results
From 2015-2019, 566 CRTs were implanted (26.1% female, follow-up duration 18.9 ± 15.8 months). Among these patients, 53.5% had &lt; 75 years old and 46.5% ≥ 75 years. Baseline clinical characteristics were similar, except for a higher prevalence of chronic kidney disease and atrial fibrillation in the elderly population. The proportion of CRT-D/CRT-P was different between these groups (p &lt; 0.001): in the elderly group, more CRT-P were implanted (67.6% vs 32.4 CRT-D) and in the younger group more CRT-D were implanted (77.9% vs 22.1% CRT-P).
The prevalence of complications due to CRT implant was similar in the two groups (4.7% vs 4.2%, p = NS) but the need for surgical revision was less frequent in the elderly group (11.0% vs 5.7%, p = 0.03). The CRT response rate was equivalent in both groups (40.1% vs 59.9%, p = NS), as was the super-response rate (33% in young vs 26.5% in old patients, p = NS).
In the elderly population, the 4-year survival rate was similar between CRT-P and CRT-D patients (75.4% vs 79.8%).

Conclusion
Patients older than 75 years old have similar benefits from the CRT as patients &lt; 75 years, with equivalent response rates to CRT. However, judging from the similar prognostic impact of CRT-P vs CRT-D in this elder population, the implant of a defibrillator should be personalized.
P544Evaluation of three-dimensional trajectory of pacing cathode pole in coronary sinus to predict long-term response to cardiac resynchronization therapy
Authors: Tomasi C , Severi S , Zanon F , Molon G , Corzani A , Rossillo A , Biffi M , Marcantoni L , Costa A , Dal Monte A , Santarelli G , Lanzoni L , Corsi C 
Published: June 2020

Abstract

Background
An automated method for 3D reconstruction of coronary sinus (CS) lead’s pacing cathode trajectory (3DTJ) was proposed to acutely predict long term left ventricular (LV) mechanic response to cardiac resynchronization therapy (CRT). Preliminary data showed that 3DTJ at biventricular pacing (BIV) start changed in CRT responders (R) to be, becoming less eccentric and more multi-directional, as described by the ratio between its two major axes (S1/S2).

Purpose
The TRAJECTORIES study (Trajectory Changes Of Coronary Sinus Lead Tip And Cardiac Resynchronization Therapy Outcome, NCT02340546) is an observational study by seven Italian centers about the prediction of CRT-induced LV reverse remodeling by means of the acute 3DTJ changes at CRT implant.

Methods
In CRT implants with standard indications, stable CHF and regular ventricular rhythm, a fluoroscopic sequence in two standard X-rays views of a few seconds was acquired immediately before (T-1) and after the start of BIV (T0). 3DTJ of CS lead cathode pole throughout the cardiac cycle at T-1 and T0 were reconstructed and analyzed. Changes of the ratio between its two major axes (S1/S2) between T-1 and T0 (ΔS1/S2), were compared with the volumetric response at six-month f.u: the percent negative variation of S1/S2 (ΔS1/S2 &lt; 0), marking a more multi-directional shape of 3DTJ, was assumed to predict the response to CRT. Volumetric response was adjudicated by a core-lab using a cut-off reduction ≥ 15% in echocardiographic LV end-systolic volume at f.u..

Results
Out of 119 patients enrolled in 42 months, 74 pts ended f.u. (55 m; age 69 ± 10) and 30 dropped–out. Patients baseline features were: ischemic heart disease (IHD) 34 /74 pts; sinus rhythm 64/74 pts; upgrade from PM/ICD 13/74 pts; QRS morphology with LBBB 57/74, intraventricular aspecific delay 6 and RV pace 11 pts; LV ejection fraction (EF) 30 ± 9%; QRS duration 162 ± 25 ms. At f.u., volumetric R were 45/74 (60%). Concordance between ΔS1/S2 (as either ΔS1/S2 &lt; 0 or ΔS1/S2 &gt; 0) and volumetric response was 77% overall (57/74), 82% in R (37/45), 69% in non-R (20/29). Non-concordant patients were mostly non-R: 52% vs 35% of non-R in concordant group, but no other differences were found. The proposed 3DTJ metric showed sensitivity = 72%, specificity =80%; positive predictive value = 69%, negative predictive value = 82%.

Conclusions
Metrics of 3DTJ can be useful to acutely predict CS pacing site-specific response to CRT in long-term, above all in R. 3DTJ assessment might highlight aspects of CRT effects on LV mechanics.
P471Experience with the use of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with atrial fibrillation and a high risk of hemorrhagic complications
Authors: Emelina E , Gendlin G , Nikitin I 
Published: June 2020

Abstract
Background. The use of NOACs in patients with chronic lymphocytic leukemia (CLL) is a difficult task due to the tendency to hemorrhage in these patients associated with CLL. The use of targeted ibrutinib (Ib) therapy in the treatment of CLL patients increases the risk of bleeding due to thrombocytopathy. A feature of targeted Ib therapy is the need for daily and lifelong use. One of the cardiotoxic effects of Ib is the development of atrial fibrillation (AF). Some patients receiving Ib have a history of AF. Warfarin is contraindicated in patients taking Ib, so all patients received NOACs.
Purpose. To evaluate the possibility of using NOACs in CLL patients receiving Ib, taking into account the frequency and severity of hemorrhagic manifestations, the need to cancel, reduce the dose and replace with another NOACs.
Methods. We examined and observed the dynamics of 224 patients with CLL receiving Ib from 5 to 56 months at a dose of 420 mg per day as 1, 2, 3, and 4 lines of CLL therapy. Patients with CLL aged 32 to 91 years (66.0 (59.0-72.0) years) were Included, of whom 82 are women aged 39 to 83 years (64.0 (54.0-71.0 ) years) and 142 men aged 32 to 91 years (66.0 (60.0-72.0) years). All hemorrhagic manifestations in patients receiving Ib and NOACs were evaluated, taking into account the glomerular filtration rate and platelet count.
Results. AF were revealed in 51 patients with CLL receiving Ib. AF was registered in 32 patients during the treatment with Ib, in 19 patients AF was before prescribing of Ib. The need for NOACs because of AF arose in 38 patients with CLL who were prescribed rivaroxaban (n = 11), dabigatran (n = 6), apixaban (n = 21). Hemorrhages were observed in 88.2% of patients receiving NOACs and Ib, represented by hematomas (n = 32), petechiae (n = 4), nosebleeds (n = 6), gingival bleeding (n = 7), hemorrhage in the anterior chamber of the eye (n = 1), hemorrhage in the sclera of the eye (n = 3) and macrohematuria (n = 4). A combination of several hemorrhagic manifestations (combined hemorrhages) was observed in 40.7% of CLL patients receiving NOACs. 10 patients were transferred to the minimum dose of apixaban 2.5 mg twice a day due to the development of recurring nosebleeds (n = 5), macrohematuria (n = 3), large, recurring hematomas with localization on the neck and face (n = 1 ), hemorrhages in the anterior chamber of the eye (n = 1). Cancellation of NOACs in 1 patient was associated with recurrent macrohematuria. Rivaroxaban 20 mg per day was canceled in 6 patients due to the development of persistent thrombocytopenia of less than 50 × 109/L. Conclusions. There were no life-threatening hemorrhages. The main reason for the withdrawal of NOACs was persistent thrombocytopenia. Due to hemorrhagic complication, NOACs was canceled only in 1 patient, 10 patients (26.3%) required a transfer to the minimum dose of apixaban. The arising hemorrhages did not require hospitalization of patients.
P1450Deep vein thrombosis after right sided catheter ablation; more common then previously thought?
Authors: Bruce C , Rogers S , Saraf K , Kirkwood G , Kirkland N , Wright M , Jamil-Copley S , Abozguia K , Fox D , Mccollum C , Morris G 
Published: June 2020

Abstract

Funding Acknowledgements
Bristol-Myers Squibb

Background
Right sided cardiac catheter ablation has become an indispensable tool to treat supraventricular cardiac dysrhythmias, with ablation of certain arrhythmias having cure rates over 90%. Due to this the frequency of these procedures is increasing annually and it is imperative we understand the incidence of all complication. One lesser studied complication is that of deep vein thrombosis (DVT), for which catheter ablation demonstrates all elements of Virchow"s triad. As right sided ablations are carried out to treat troublesome palpitations, not to reduce mortality, it is important all risks are identified, especially those which are themselves potentially life threatening and can be modified.

Purpose

To determine the incidence of DVT after right sided cardiac catheter ablation.

Methods

We undertook a prospective multi-center study recruiting adult patients undergoing clinically indicated cardiac ablation for atrioventricular nodal re-entrant tachycardia and atrioventricular re-entrant tachycardia with right sided accessory pathway. Important exclusion criteria included patients on anticoagulation or antiplatelet therapy. Participants underwent bilateral compression venous duplex ultrasonography from the inferior vena cava to the popliteal vein to access for DVT at 24 hours and between 10 to 14 days post-procedure. The uncannulated contralateral leg acted as a control.

Result

At interim analysis 71 participants had completed the study with average age 47 year (+/- 14), procedure duration 67 minutes, and with a female predominance. Seven patients developed acute DVT in either the femoral or internal iliac vein in the access leg. No thrombus was seen in the control leg. This gives an incidence of 10% (95% CI 4-19%) with p value of 0.023 on Chi-square testing.

Conclusion
We found a statistically significant proportion of patients undergoing right sided cardiac catheter ablation developed acute proximal DVT on ultrasound. All patients were treated with 3 to 6 months of anticoagulation therapy in accordance with NICE guidelines. These results suggest that DVT may occur at a high frequency then previously thought in this cohort and supports the consideration of peri-procedural prophylactic anticoagulation.
Abstract Figure. Acute thrombus in the femoral vein