bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract A015: Post-treatment patient-provider communication and follow-up care: Does written patient-provider communication improve timely follow-up care for rural cancer survivors?
Authors: Lewis-Thames Marquita W. , Carnahan Leslie R. , James Aimee S. , Watson Karriem S. , Molina Yamilé 
Published: September 2020

Abstract
Purpose: Patient-provider communication is a facilitator for optimizing cancer survivorship care planning. As disparities in rural-urban survivorship rates continue to widen, patient-provider communication regarding post-treatment survivorship care is a potential mechanism to improve survivorship-related outcomes. The current study examines sociodemographic and health predictors of post-treatment patient-provider communication and follow-up care, and associations between written communication and timely follow-up care for rural cancer survivors. Methods: Data was analyzed from post-treatment cancer survivor respondents of the Illinois Rural Cancer Assessment Study. The current study tested associations between sociodemographic variables and health factors on the quality of patient-provider communication and timely post-treatment follow-up care, defined as visits within three months or less of final treatment, and associations between the receipt of written patient-provider communication on timely post-treatment follow-up care. Results: Among 90 rural cancer survivors, respondents with annual incomes less than $50,000 and having a high school diploma or less were more likely to report a high quality of post-treatment patient-provider communication. Post-treatment written communication was reported by 62% of the respondents and 52% reported timely follow-up visits during the first three years of post-treatment care. Patients who reported receiving written patient-provider communication were five times more likely to have timely post-treatment follow-up care after completing active treatment than patients who had not received written patient-provider communication. Conclusions: For rural cancer survivors, written patient-provider communication improved timely follow-up care. This research supports policy and practice that recommends the receipt of a written survivorship care plans. Implementation of written survivorship care recommendations improves timely follow-up visits and has the potential to eliminate cancer survivorship disparities.
Citation Format: Marquita W. Lewis-Thames, Leslie R. Carnahan, Aimee S. James, Karriem S. Watson, Yamilé Molina. Post-treatment patient-provider communication and follow-up care: Does written patient-provider communication improve timely follow-up care for rural cancer survivors? [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr A015.
Abstract A027: Myths and traditions in the African American community
Authors: Herring Loretta 
Published: September 2020

Abstract
The poster will display the trends and traditions that have hindered the growth of knowledge in the African Americans Communities, dealing with the diagnoses of cancer, research participation, and clinical studies. Myths, misconceptions and mistrust dealing with health disparities.
Citation Format: Loretta Herring. Myths and traditions in the African American community [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr A027.
Abstract A033: Communication leads to cancer research and education
Authors: Walker McKinley 
Published: September 2020

Abstract
Communication leads to cancer research and education.
Citation Format: McKinley Walker. Communication leads to cancer research and education [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr A033.
Abstract A038: What about me? A content analysis of triple-negative breast cancer clinical trial inclusion eligibility criteria
Authors: Ridley-Merriweather Katherine E 
Published: September 2020

Abstract
Triple negative breast cancer (TNBC) is noticeably more prevalent in Black women than White, while women from these two groups exhibit similar incidence rates for breast cancers (BCs) that test positive for overexpression of the HER2 receptor (HER2+BC). This content analysis explores whether the available evidence and general knowledge among BC researchers of the significantly higher TNBC incidence rates by African American women than Caucasian women is reflected in the eligibility criteria inclusion language of TNBC clinical trials. Data gathered from clinicaltrials.gov was used in a comprehensive analysis on the text of the trial description and eligibility criteria inclusion language of all eligible clinical trials. Three themes resulted: 1) Similarities in TNBC/HER2+BC eligibility criteria inclusion language; 2) differences in TNBC/HER2+BC eligibility criteria inclusion language; and 3) recruitment language oversights. Four characteristics of the data sets (age requirements, prerequisite of invasive BC, previous treatment for BC, determined life expectancy period) were determined to be similar, and two characteristics (breast surgery restrictions, metastases) were identified as demonstrating a level of difference. Despite well-demonstrated evidence that TNBC measurably, significantly, and disproportionately affects women of African descent, young (particularly Latina) women, and women testing positive for BRCA mutation, there is strong evidence that these risk factors are not at all addressed in the formal inclusion language of BC CTs posted on clinicaltrials.gov. The implications of this work suggest further research to ascertain whether there are efforts to recruit any of these populations independently of the site’s formal listings.
Citation Format: Katherine E Ridley-Merriweather. What about me? A content analysis of triple-negative breast cancer clinical trial inclusion eligibility criteria [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr A038.
Abstract A041: Community engagement in the development of an m-health app utilizing a black male virtual health assistant (VHA) to promote colon cancer screening: An iterative study of credibility and likeability
Authors: Wilson-Howard Danyell , Vilaro Melissa , Griffin Lauren , Travassoli Fatemeh , Zalake Mohan , Lok Benjamin , Modave Francois , Carek Peter , George Thomas , Krieger Janice 
Published: September 2020

Abstract
Traditionally, promotion of colorectal cancer (CRC) screening among minority and rural populations including African American men was delivered by Community Health Workers (CHW), Patient Navigators, and decision aids (printed text or video media) at clinics. A novel approach to increase CRC screening of black men includes developing and utilizing a patient-centered, tailored message delivered via mobile-health (m-health) technology. In this study, a Community Based Participatory Research (CBPR) approach provided feedback on a Virtual Health Assistant (VHA) designed to deliver precision and personalized messages promoting the Fecal Immunochemical Test (FIT) for CRC screening. Focus groups of Black men were recruited to understand and employ their perceptions of a Black-male VHA. Specifically, these men identified source characteristics that would enhance the credibility of the VHA and likeability of an m-health app. The MAIN Model which examines how an interface features affect the user’s psychology through four Affordances: Modality, Agency, Interactivity, and Navigability was used to assess the presumed credibility of the VHA and likability of the app from the focus group transcripts. Each affordance triggers heuristic cues that stimulate a positive or negative perception of trustworthiness, believability, and understandability thereby increasing source credibility and likability. Data collected in the focus group included feedback on the different content modalities, both text and visual: size and font of the text, VHA appearance, voice, movement, diction, the environment as well as perceptions of the trustworthiness and expertise of the interface. Data related to interactivity and ease of navigation through the app was also collected and analyzed. All in all, 25 Black men from the community contributed to the development of three iterations of a Black male VHA over an eighteen-month time span. The final version of the Black male-VHA, ALEX is now part of an intervention to increase CRC screening among minority and rural populations.
Citation Format: Danyell Wilson-Howard, Melissa Vilaro, Lauren Griffin, Fatemeh Travassoli, Mohan Zalake, Benjamin Lok, Francois Modave, Peter Carek, Thomas George, Janice Krieger. Community engagement in the development of an m-health app utilizing a black male virtual health assistant (VHA) to promote colon cancer screening: An iterative study of credibility and likeability [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr A041.
Abstract A053: Association between socioeconomic status and access to specialized cancer consultation and treatment among advanced gastrointestinal cancers
Authors: Davis Laura E , Coburn Natalie G , Hallet Julie , Earle Craig C , Myrehaug Sten , Li Ying , Mahar Alyson L 
Published: September 2020

Abstract
Introduction: Gastrointestinal (GI) cancers of the pancreas, esophagus, stomach, colon and rectum often present at an incurable stage. Treatments such as chemotherapy and radiotherapy can improve quality and quantity of life for patients with these advanced gastrointestinal (GI) cancers. However, many patients fail to receive such treatments or even consult with a cancer specialist to determine if treatment is an option. Socioeconomic status (SES) is associated with cancer outcomes, but the mechanisms as to why, such as access to specialized care, are not clearly established. This study examined the association between SES and receipt of specialized cancer consult and treatment in Ontario, Canada. Methods: This was a population-based retrospective cohort study of advanced GI cancer patients diagnosed between 2007 and 2017 using linked administrative databases. The exposure of SES was defined using the deprivation item in the Ontario Marginalization Index. The outcome of oncology consult was defined as a consultation with either a radiation oncologist or a medical oncologist and the outcome of treatment was defined as receipt of chemotherapy or radiotherapy. Both were measured in the year following diagnosis. Multivariable Cox-proportional hazards regression models were used to determine association of deprivation with oncology consult and treatment. Confounders identified a priori include age, sex, comorbidities and cancer site. Results: 29,297 patients had a diagnosis of advanced GI cancer and were included in the study. 27.4% of the cohort did not have an oncology consult and 53.7% did not receive treatment in the year following diagnosis. The most deprived quintile compared to the least deprived quintile was associated with decreased consult (HR 0.89 (0.85-0.93)) and decreased treatment (HR 0.81 (0.77-0.86)) after adjusting for confounders. Conclusion: This study found that even in a single-payer universal healthcare system, SES is associated with access to specialized cancer care. Future research should examine mechanisms through which policy might help low SES patients access specialized cancer care.
Citation Format: Laura E Davis, Natalie G Coburn, Julie Hallet, Craig C Earle, Sten Myrehaug, Ying Li, Alyson L Mahar. Association between socioeconomic status and access to specialized cancer consultation and treatment among advanced gastrointestinal cancers [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr A053.
Abstract A057: Influence of race and economic deprivation on metastatic breast cancer outcomes
Authors: Heckman Rachel , Senthil Keerthana , Rosenzweig Margaret Quinnl , Ann Welch Hilda 
Published: September 2020

Abstract
Background: Metastatic or Stage 4 breast cancer (MBC) is a heterogeneric, life ending illness with a treatment course of multiple sequential therapies. There are documented racial disparities in breast cancer outcomes and treatment equity, but little is known about the racial or socio-economic differences during MBC and end of life (EOL) care. Aim1: Describe a cohort of patients deceased from MBC - patient, tumor, treatment, symptoms and end of life care characteristics. Aim 2 – Compare patient, symptoms and end of life care characteristics according to race and neighborhood deprivation. Methods: Cohort of deceased patients from large, breast cancer program from October 2016 until June 2019. Protocolized, retrospective chart review for patient (age, race, neighborhood deprivation score,derived from zip code), tumor (ER, PR, Her 2, subtype), symptoms (25 symptoms + overall wellbeing rated 0-10 at last visit before death; generalized anxiety, screening depression and overall distress), end of life care (palliative care consult, hospice, length of time in hospice, place of death, ICU admission prior to death, goals of care discussion documented). Results: Cohort of N=130. Black - N=17 (13%); White - N=112 (86.2%). Dichotomized according to median (69) NDI, N=58 (49.2%) in more deprived neighborhoods. Triple negative breast cancer subtype N= 7(41%) Black and N=34 (30%) white. Survival: Survival overall was 1175 days. Black survival was less than half of white. Black – 501 days (SD – 339); White – 1242 days (SD 1363), p=.031.No survival differences according to neighborhood. Of the 25 symptoms measured during breast cancer treatment cough,nausea, hot flashes, headaches, and overall health were significantly (p &lt;.05) worse for black vs. white patients with no differences noted for other symptoms. Dizziness, nausea, vomiting, anxiety, depression, overall distress and overall health were significantly (P&lt;.05) worse for patients from more deprived neighborhoods. Among the 130 deceased MBC patients N=108 (81.8%) had palliative care services, N=65 (50%) had no advance directives, N=52 (40%) did not use hospice services, and N=16 (12%) died in the ICU. No difference between Black and White patients or patients from more vs. less deprived neighborhoods for these outcomes. Conclusion: There is racial and economic disparity in MBC survival and symptoms prior to death. Overall end of life planning is not well addressed in this population.
Citation Format: Rachel Heckman, Keerthana Senthil, Margaret Quinnl Rosenzweig, Welch Hilda Ann. Influence of race and economic deprivation on metastatic breast cancer outcomes [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr A057.
Abstract A063: Social context and cancer: Stress and quality of life in rural-dwelling Latina cancer survivors
Authors: Ceballos Rachel M , Ibarra Genoveva , Escareno Monica , Gonzalez Nora , Marchello Nathan 
Published: September 2020

Abstract
Introduction: Latina breast and gynecologic cancer survivors (LCS) experience higher levels of distress and lower quality of life compared to non-Latinos. This randomized control trial examined the effect of a promotora-led 10-week Spanish language support program on levels of stress and cancer-related quality of life (QOL) in LCS. Methods: Fifty-nine LCS were randomized to receive the 10-week intervention (n=30) or to a delayed-intervention control (n=29) group. Measures were assessed at baseline (T1) and upon completion of the intervention period (T2) and included the: short Hispanic Stress Inventory (HSI) [subscales: extra-familial and intra-familial stress]-version 2, the Functional Assessment of Cancer Therapy (FACT-G) QOL scale [subscales: physical (P-QOL), functional (F-QOL), emotional (E-QOL), social (S-QOL)], the FACT-Fatigue QOL scale, and a demographic survey. RESULTS: No statistically significant differences were observed between the intervention and control groups for any of the outcome variables. Perceived stress scale [t(57)=0. 37, p=0. 72], Hispanic Stress Inventory extrafamilial subroup [t(57)=1. 8, p=0. 09], and Hispanic Stress Inventory intrafamilial subgroups [t(57)=1. 5, p=0. 18]. Results for quality of life subscales were physical [t(57)=-1. 66, p=0. 10], social [t(47)=-0. 32, p=0. 75], emotional [t(57)=-0. 41, p=0. 97], and functional [t(57)=1. 38, p=0. 17] well-being. Exploratory analyses a mediating effect of extrafamilial stress on a significant relationship between Spanish-only language and lower EQOL. Conclusions: The effect of the promotora-led intervention was not significant. However, an exploratory mediation analyses identified a significant role of extrafamilial (ethnic-based) stress among Spanish-only speakers with EQOL. A detailed presentation of study findings, including a critique of the intervention design and implications for the effect of social context on cancer-related outcomes will be discussed.
Citation Format: Rachel M Ceballos, Genoveva Ibarra, Monica Escareno, Nora Gonzalez, Nathan Marchello. Social context and cancer: Stress and quality of life in rural-dwelling Latina cancer survivors [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr A063.
Abstract A067: Oncotype DX assay has similar predictive accuracy for adverse pathology at radical prostatectomy in African American and European American men
Authors: Carbunaru Samuel , Marcias Virgilia , Gann Peter , Sharifi Roohollah , Yang Ximing , Dixon Michael , Gorbein Chase , Jovanovic Borko , Kajdacsy-Balla Andre , Murphy Adam B. 
Published: September 2020

Abstract
Objective: To validate the 17-gene Oncotype DX Genomic Prostate Score (GPS) biopsy-based gene expression assay as a predictor of adverse pathology (AP: Pathologic Gleason score ≥4+3, presence of any Gleason 5, and/or ≥pT3) in African American (AA) men. Methods: Between February 2009 and September 2014, AA and European American (EA) men with very low, low, and intermediate risk prostate cancer (PCa) enrolled in a multi-institutional prospective study of vitamin D impacts of biopsy outcomes. The subset who proceeded to immediate radical prostatectomy (RP) after biopsy with available biopsy tumor blocks was included in a comparative effectiveness analysis of GPS on biopsy and its association with surgical AP on RP using logistic regression and receiver operating characteristic curves. Multiplicative interactions tested for differential prediction of GPS accuracy by race (AA vs. EA). Results: Overall, 102 AA and 76 EA men elected RP, out of which 51 (47.2%) had AP. GPS result was a significant predictor of AP (odds ratio per 20 GPS units [OR/20 units] in AA: 4.78; 95% CI 1.8-12.5, P =0.001; and EA: 4.41; 95% CI 1.6-11.9, P =0.003) in univariable analysis. On multivariate analysis, there was a significant interaction between GPS and race (P=0.01). On race stratified binary logistic regression, AP remained significant after adjustment for NCCN risk group in both AA and EA men (OR/20 units in AA: 3.29; 95% CI 1.2-9.1, P =0.02; and EA: 4.24; 95% CI 1.4-12.6, P =0.01). Area under the curves for AP using GPS/20 units was 0.719 for AAs vs. 0.745 for EAs (P=0.39). Conclusion: In this AA validation study, the Oncotype Dx PCa assay was confirmed as an independent predictor of AP at prostatectomy in AA and EA men with similar predictive accuracy, though there was evidence of effect modification by race.
Citation Format: Samuel Carbunaru, Virgilia Marcias, Peter Gann, Roohollah Sharifi, Ximing Yang, Michael Dixon, Chase Gorbein, Borko Jovanovic, Andre Kajdacsy-Balla, Adam B. Murphy. Oncotype DX assay has similar predictive accuracy for adverse pathology at radical prostatectomy in African American and European American men [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr A067.
Abstract A069: TRPV6 as a putative genomic susceptibility locus influencing racial disparities in cancer
Authors: Francis-Lyon Patricia , Malik Fahreen , Cheng Xiaoyun , Ghezavati Alireza , Xin Feihan , Cai Rafiki 
Published: September 2020

Abstract
It is well established that African Americans exhibit higher incidence, higher mortality, and more aggressive forms of some cancers, including those of breast, prostate, colon, stomach, and cervix. Here we examine the ancestral haplotype of the TRPV6 calcium channel as a putative genomic factor in this racial divide. The minor (ancestral) allele frequency is 60% in those of African Ancestry, but between 1 and 11% in all other 1000 Genomes populations. Recent research on TRPV6 structure/function, its association with specific cancers, and the evolutionary-ecological conditions which impacted selection at its locus are synthesized to provide evidence for the TRPV6 haplotype as a germline susceptibility locus in cancer. Examination of a recently-proposed model for TRPV6 Ca2+-dependent inactivation, as it relates to the haplotype SNP identified as the target of selection, is proposed here as an explanatory mechanism for hypothesized failure to inactivate the channel at high Ca2+ concentrations in those who have the ancestral haplotype. This could result in an over-abundance of cellular Ca2+, which has been implicated in cancer, for those in settings where calcium dietary and supplemental intake is far higher than in their ancestral environment. This synthesis of recent research makes a case for investigation into the TRPV6 haplotype as a genomic factor in cancer disparity. If TRPV6 is found to be implicated, future research would be warranted to improve risk assessment and examine interventions with the aim of improving cancer outcomes for people of African descent.
Citation Format: Patricia Francis-Lyon, Fahreen Malik, Xiaoyun Cheng, Alireza Ghezavati, Feihan Xin, Rafiki Cai. TRPV6 as a putative genomic susceptibility locus influencing racial disparities in cancer [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr A069.