bluuebunny/crossref_metadata_2025_split huggingface dataset:
An integrated Grey-DEMATEL approach for evaluating ICT adoption barriers in manufacturing SMEs
Authors: Singh Amit , Thakkar Jitesh , Jenamani Mamata 
Published: December 2019

PurposeThe purpose of this paper is to propose an integrated gray-decision making trial and evaluation laboratory (Grey-DEMATEL) framework to evaluate the ICT adoption barriers in manufacturing small and medium enterprises (MSMEs) running in developing countries. The proposed model is also tested for Indian MSMEs.Design/methodology/approachThe model consists of 16 potential ICT adoption barriers selected from existing literature and refined based on discussion with domain experts. While DEMATEL analyses causal relationship and prioritizes them, Grey approach tackles individual biases and data insufficiency.FindingsThe authors conclude that lack of awareness about benchmarking and lack of management vision are the most critical ICT adoption barriers in the case of Indian MSMEs.Research limitations/implicationsOutcomes of the present research are based on the experts’ inputs which are subject to the biases related to their experience and exposure. In India practices adopted by SMEs have geographical and political influence that is also neglected.Originality/valueThis study provides a model consisting of 16 ICT adoption barriers for MSMEs in developing country and a framework to analyze causal relationships among the barriers with the flexibility of data input from their own domain experts. The framework is also capable of dealing with expert biases and data insufficiency.
Predicted temperature development on protected cellular steel beam (CSB) under fire exposure
Authors: Ahmad Zakwan Fariz Aswan , Ismail Ruqayyah , Krishnamoorthy Renga Rao , Ibrahim Azmi 
Published: December 2019

Purpose
This paper aims to investigate the predicted temperature behaviour of the protected cellular steel beam (CSB) with circular web openings at elevated temperature through finite element simulation.

Design/methodology/approach
Temperature development along the CSB were analysed and used for parametric investigation. In addition, this research paper investigates the novelty application of various intumescent coating thicknesses covering the whole CSB to cut down the temperature development along the beam section.

Findings
From the simulation outcomes, it shows that intumescent coating has a significant effect in reducing the temperature development along the CSB section. Thicker intumescent coating contributes to a higher temperature drop at the bottom tee section than the upper tee section.

Originality/value
The use of structural CSB has gained popularity among engineers and architects. This type of beam allows serviceability ducts and pipes to pass through the main steel web section under the flooring system, thus providing larger headroom for designers. Nevertheless, in any structural steel building, it is highly risky for CSB to be exposed to fire hazard if it were triggered accidentally. To mitigate and reduce fire exposure risk which might compromise the strength and stiffness of CSB, a passive fire protection is proposed to minimise the risk. One of the common passive fire protection materials used for steel beam section is intumescent coating. Intumescent coating is by far the cheapest solution to protect CSB as compared to other passive fire protection system. Intumescent coating can absorb some portion of heat exposure which subsequently translates a lower temperature development along the CSB section.
Cutaneous fusariosis caused by Fusarium lichenicola in a child with hyper‐immunoglobulin E syndrome
Authors: Shi Minglan , Lu Sha , Li Jiahao , Cai Wenying , Zhang Jing , Ma Jianchi , Li Xiqing , Xi Liyan , Zhang Junmin 
Published: December 2019

AbstractFusariosis is the second most common mold infection after aspergillosis, and keratomycosis is the most encountered implantation infection. Here, we report a case of a 4‐year‐old Han Chinese girl presenting with an itchy mass on her right face of almost 2 years’ duration. Direct smear of the lesion sample was positive for fungal hyphae. Biopsy of the lesion showed many fungal hyphae in the epidermis and dermis. The pathogen was identified as Fusarium lichenicola by molecular sequencing and phylogenetic analysis based on the TEF‐1α gene. Whole‐exome sequencing analysis using her peripheral blood revealed a heterozygous mutation in the STAT3 gene, which is related to autosomal dominant hyper‐immunoglobulin E syndrome (AD‐HIES). The lesion improved following treatment with i.v. and intralesional amphotericin B, oral voriconazole and topical luliconazole cream. To our knowledge, this is the second reported case of a special localized cutaneous lesion caused by Fusarium species in a child with AD‐HIES. Both cases suggest that STAT3 deficiency may increase susceptibility to fusariosis.
Water potential gradient, root conduit size and root xylem hydraulic conductivity determine the extent of hydraulic redistribution in temperate trees
Authors: Hafner Benjamin D. , Hesse Benjamin D. , Bauerle Taryn L. , Grams Thorsten E. E. 
Published: December 2019

Abstract

Hydraulic redistribution (HR) of soil water through plant roots is widely described; however its extent, especially in temperate trees, remains unclear. Here, we quantified HR of five temperate tree species. We hypothesized that both, HR within a plant and into the soil increase with higher water‐potential gradients, larger root conduit diameters and root‐xylem hydraulic conductivities as HR driving factors.

Saplings of conifer (Picea abies, Pseudotsuga menziesii), diffuse‐porous (Acer pseudoplatanus) and ring‐porous species (Castanea sativa, Quercus robur) were planted in split‐root systems, where one plant had its roots split between two pots with different water‐potential gradients (0.23–4.20 MPa). We quantified HR via deuterium labelling.

Species redistributed 0.39 ± 0.14 ml of water overnight (0.08 ± 0.01 ml/g root mass). Higher pre‐dawn water‐potential gradients, hydraulic conductivities and larger conduits significantly increased HR quantity. Hydraulic conductivity was the most important driving factor on HR amounts, within the plants (0.03 ± 0.01 ml/g) and into the soil (0.06 ± 0.01 ml/g).

Additional factors as soil‐root contact should be considered, especially when calculating water transfer into the soil. Nevertheless, trees maintaining high‐xylem hydraulic conductivity showed higher HR amounts, potentially making them valuable ‘silvicultural tools’ to improve plant water status.

A free Plain Language Summary can be found within the Supporting Information of this article.
Central Transfer a Curse or Blessing? Evidence from the Relative Revenue Effort of Indian States
Authors: Mohanty Avipsa , Sethi Dinabandhu , Mohanty Asit Ranjan 
Published: December 2019

AbstractThis paper evaluates the revenue effort of Indian states during the 13th and 14th Finance Commission periods and estimates the impact of central transfers recommended by the Finance Commission on the relative revenue effort of states. Using panel data the study finds that Bihar, Uttar Pradesh, Madhya Pradesh, Assam and Kerala are the top five states with the greatest relative revenue effort. Further, the impact of central transfers on revenue effort was found to be negative, suggesting that greater devolution encourages laxity in the state's tax collection efficiency by providing perverse incentives.
Long‐term patient‐important outcomes after septic shock: A protocol for 1‐year follow‐up of the CLASSIC trial
Authors: Kjær Maj‐Brit N. , Meyhoff Tine S. , Madsen Martin B. , Hjortrup Peter B. , Møller Morten Hylander , Egerod Ingrid , Wetterslev Jørn , Lange Theis , Cronhjort Maria , Laake Jon H. , Jakob Stephan M. , Nalos Marek , Pettilä Ville , van der Horst Iwan C. C. , Ostermann Marlies , Mouncey Paul , Cecconi Maurizio , Ferrer Ricard , Malbrain Manu L. N. G. , Ahlstedt Christian , Hoffmann Søren , Bestle Morten H. , Gyldensted Louise , Nebrich Lars , Russell Lene , Vang Marianne , Sølling Christoffer , Brøchner Anne C. , Rasmussen Bodil S. , Perner Anders 
Published: December 2019

BackgroundIn patients with septic shock, mortality is high, and survivors experience long‐term physical, mental and social impairments. The ongoing Conservative vs Liberal Approach to fluid therapy of Septic Shock in Intensive Care (CLASSIC) trial assesses the benefits and harms of a restrictive vs standard‐care intravenous (IV) fluid therapy. The hypothesis is that IV fluid restriction improves patient‐important long‐term outcomes.AimTo assess the predefined patient‐important long‐term outcomes in patients randomised into the CLASSIC trial.MethodsIn this pre‐planned follow‐up study of the CLASSIC trial, we will assess all‐cause mortality, health‐related quality of life (HRQoL) and cognitive function 1 year after randomisation in the two intervention groups. The 1‐year mortality will be collected from electronic patient records or central national registries in most participating countries. We will contact survivors and assess EuroQol 5‐Dimension, ‐5‐Level (EQ‐5D‐5L) and EuroQol‐Visual Analogue Scale and Montreal Cognitive Assessment 5‐minute protocol score. We will analyse mortality by logistic regression and use general linear models to assess HRQoL and cognitive function.DiscussionWith this pre‐planned follow‐up study of the CLASSIC trial, we will provide patient‐important data on long‐term survival, HRQoL and cognitive function of restrictive vs standard‐care IV fluid therapy in patients with septic shock.
Impact of traumatic birth on Australian obstetricians: A pilot feasibility study
Authors: Walker Andrea L. , Gamble Jenny , Creedy Debra K. , Ellwood David A. 
Published: December 2019

BackgroundTraumatic stress can adversely affect obstetricians’ mental health and may affect care provision. Little is known about the impact of traumatic birth on the Australasian obstetric workforce.AimTo assess the feasibility of conducting a binational survey of Australia and New Zealand obstetricians, trainees, and general practitioner obstetricians, to determine the prevalence of trauma exposure and associated factors.Materials and MethodsFeasibility was assessed using a convergent mixed‐methods design. The pilot online survey assessed traumatic exposure and included the Posttraumatic Diagnostic Scale, Copenhagen Burnout Inventory (work subscale), and Posttraumatic Growth Inventory (short form). Qualitative data were generated from survey comments and telephone interviews and thematically analysed.ResultsUsing various recruitment strategies, 32 participants completed the survey, and eight completed interviews. Most participants were consultant obstetricians. Nearly all (n = 31, 96.9%) had been exposed to traumatic birth(s). Three‐quarters had current symptoms of traumatic stress, one‐quarter had symptoms of work‐related burnout, but over two‐fifths reported significant post‐traumatic growth. Thematic analysis revealed perceptions that ‘obstetricians experience substantial trauma’, there is a ‘culture of blame in obstetrics’, and only ‘in some workplaces it’s supportive and safe’. Feasibility issues included the need to identify the respondent’s level of training at the time when their most traumatic birth occurred, ensure anonymity of responses, and use a different tool to assess traumatic stress symptoms.ConclusionsConducting a full study of this important topic appeared feasible. Standardised measures were acceptable. Revision of some questions is required. Anonymity needs to be promoted.
Application of small‐bore pigtail catheter to improve pleural drainage after single‐incision thoracoscopic lobectomy for lung cancer
Authors: Yang Zhenhua , Hu Tianjun , Shen Haibo , Huang Hongbo 
Published: December 2019

AbstractBackgroundIn order to overcome the problems associated with the drainage of single‐incision thoracoscopic surgery, we investigated the efficiency of applying an 8‐Fr pigtail catheter in addition to the conventional 26‐Fr chest tube.MethodsThis prospective study includes 88 consecutive patients who underwent single‐incision thoracoscopic lobectomy between July 2017 and March 2018. Patients were treated either with (smaller pigtail group) or without (larger drain group) 8‐Fr pigtail catheter in addition to conventional 26‐Fr chest tube. Post‐operative recovery was assessed by analysing the post‐operative drainage volume on the first 2 days, the duration (days) of drainage, re‐intubation after 2 weeks, air leak time, length of stay, subcutaneous emphysema, pleural effusion after 2 weeks and pain score.ResultsThe patients in the pigtail tube group had a significantly shorter drainage time and higher drainage volume on the first 2 days than those in the larger drain group. The percentage of patients that developed pleural effusion after 2 weeks was 4.54% in the smaller pigtail group and 25% in the larger drain group (P = 0.007). The pain score in the smaller pigtail tube group decreased significantly on the third day after surgery compared with larger drain group (P < 0.001). There were no significant differences between the two groups in the air leak time, subcutaneous emphysema, wound healing and pain score on the first day.ConclusionApplication of 8‐Fr pigtail catheter after single‐incision thoracoscopic lobectomy for primary lung cancer can accelerate the post‐operative recovery of patients.
Current status of endoscopic surgery in Japan: The 14th National Survey of Endoscopic Surgery by the Japan Society for Endoscopic Surgery
Authors: Inomata Masafumi , Shiroshita Hidefumi , Uchida Hiroki , Bandoh Toshio , Akira Shigeo , Yamaguchi Shigeki , Kurokawa Yukinori , Seki Yosuke , Eguchi Susumu , Wada Norihito , Takiguchi Shuji , Ieiri Satoshi , Endo Shunsuke , Iwazaki Masayuki , Sato Yukio , Tamaki Yasuhiro , Kitamura Kaoru , Tabata Minoru , Kanayama Hiroomi , Mimata Hiromitsu , Hasegawa Toru , Takahashi Hiroshi , Onishi Kiyoshi , Uemura Tetsuji , Hashizume Makoto , Matsumoto Sumio , Kitano Seigo , Watanabe Masahiko 
Published: December 2019

AbstractIn Japan, the first endoscopic surgery, a laparoscopic cholecystectomy, was performed in 1990. Since then, operative procedures have been standardized, and the safety and efficacy of endoscopic surgery have been evaluated. In accordance with the social acceptance of endoscopic surgery as a less invasive type of surgery, the number of endoscopic procedures performed has increased in all surgical domains. The Japan Society for Endoscopic Surgery (JSES) has played an important role in the development of endoscopic surgery in Japan. Notably, a technical skills certification system for surgeons was established by the JSES to train instructors on how to teach safe endoscopic surgery. Furthermore, the JSES has conducted a national survey every two years to evaluate the status of endoscopic surgery over time. In 2017, 248 743 patients underwent endoscopic surgery in all surgical domains, such as abdominal, thoracic, mammary and thyroid gland, cardiovascular, obstetrics and gynecology, urologic, orthopedic, and plastic surgery. The 14th National Survey of Endoscopic Surgery conducted by the JSES demonstrated the status of laparoscopic surgery in Japan in 2016‐2017.
Impacts of NRF2 activation in non–small‐cell lung cancer cell lines on extracellular metabolites
Authors: Saigusa Daisuke , Motoike Ikuko N. , Saito Sakae , Zorzi Michael , Aoki Yuichi , Kitamura Hiroshi , Suzuki Mikiko , Katsuoka Fumiki , Ishii Hirofumi , Kinoshita Kengo , Motohashi Hozumi , Yamamoto Masayuki 
Published: December 2019

AbstractAberrant activation of NRF2 is as a critical prognostic factor that drives the malignant progression of various cancers. Cancer cells with persistent NRF2 activation heavily rely on NRF2 activity for therapeutic resistance and aggressive tumorigenic capacity. To clarify the metabolic features of NRF2‐activated lung cancers, we conducted targeted metabolomic (T‐Met) and global metabolomic (G‐Met) analyses of non–small‐cell lung cancer (NSCLC) cell lines in combination with exome and transcriptome analyses. Exome analysis of 88 cell lines (49 adenocarcinoma, 14 large cell carcinoma, 15 squamous cell carcinoma and 10 others) identified non–synonymous mutations in the KEAP1, NRF2 and CUL3 genes. Judging from the elevated expression of NRF2 target genes, these mutations are expected to result in the constitutive stabilization of NRF2. Out of the 88 cell lines, 52 NSCLC cell lines (29 adenocarcinoma, 10 large cell carcinoma, 9 squamous cell carcinoma and 4 others) were subjected to T‐Met analysis. Classification of the 52 cell lines into three groups according to the NRF2 target gene expression enabled us to draw typical metabolomic signatures induced by NRF2 activation. From the 52 cell lines, 18 NSCLC cell lines (14 adenocarcinoma, 2 large cell carcinoma, 1 squamous cell carcinoma and 1 others) were further chosen for G‐Met and detailed transcriptome analyses. G‐Met analysis of their culture supernatants revealed novel metabolites associated with NRF2 activity, which may be potential diagnostic biomarkers of NRF2 activation. This study also provides useful information for the exploration of new metabolic nodes for selective toxicity towards NRF2‐activated NSCLC.
Analyzing the relationship between Altmetric score and literature citations in the Implantology literature
Authors: Warren Victor T. , Patel Bhumika , Boyd Carter J. 
Published: December 2019

AbstractBackgroundThe influence of research has long been studied using citations and impact factors (IFs). Electronic media is changing how people interact with the scientific literature. There are few investigations into these trends.PurposeTo explore whether Altmetrics correlate with traditional bibliometrics in the Implantology literature.Materials and MethodsFive Implantology journals with the highest IF and the 10 most highly‐cited articles within those journals from 2013 to 2016 were reviewed. Altmetric score, citation count, and media “mentions” were recorded. Comparisons were conducted between Altmetric score, citations, and IF by performing Pearson correlation coefficients and descriptive statistics. Twitter accounts were studied and compared to other metrics.ResultsAnalysis revealed no correlation between citations and Altmetrics (r = .096,P = .506) or IF and Altmetrics (r = .111,P = .443) in 2013. Altmetrics were also not significantly correlated with citations (r = 0.148,P = .305) or IF (r = .145,P = .315) in 2016. Total Altmetric scores were nine times higher in 2016 compared to 2013, with news outlets and Twitter seeing large increases in mentions. Twitter was the top medium receiving mentions across the two cohorts.ConclusionsCompared to other fields, Implantology articles received lower Altmetric scores, noting an area of improvement. Altmetrics at this time are insufficient to replace traditional bibliometrics, but may provide helpful real‐time information concerning article dissemination.
(−)‐Phenserine tartrate (PhenT) as a treatment for traumatic brain injury
Authors: Greig Nigel H. , Lecca Daniela , Hsueh Shih‐Chang , Nogueras‐Ortiz Carlos , Kapogiannis Dimitrios , Tweedie David , Glotfelty Elliot J. , Becker Robert E. , Chiang Yung‐Hsiao , Hoffer Barry J. 
Published: December 2019

AbstractAimTraumatic brain injury (TBI) is one of the most common causes of morbidity and mortality of both young adults and the elderly, and is a key contributing factor in about 30% of all injury‐associated deaths occurring within the United States of America. Albeit substantial impact has been made to improve our comprehension of the mechanisms that underpin the primary and secondary injury stages initiated by a TBI incident, this knowledge has yet to successfully translate into the development of an effective TBI pharmacological treatment. Developing consent suggests that a TBI can concomitantly trigger multiple TBI‐linked cascades that then progress in parallel and, if correct, the multifactorial nature of TBI would make the discovery of a single effective mechanism‐targeted drug unlikely.DiscussionWe review recent data indicating that the small molecular weight drug (−)‐phenserine tartrate (PhenT), originally developed for Alzheimer's disease (AD), effectively inhibits a broad range of mechanisms pertinent to mild (m) and moderate (mod)TBI, which in combination underpin the ensuing cognitive and motor impairments. In cellular and animal models at clinically translatable doses, PhenT mitigated mTBI‐ and modTBI‐induced programmed neuronal cell death (PNCD), oxidative stress, glutamate excitotoxicity, neuroinflammation, and effectively reversed injury‐induced gene pathways leading to chronic neurodegeneration. In addition to proving efficacious in well‐characterized animal TBI models, significantly mitigating cognitive and motor impairments, the drug also has demonstrated neuroprotective actions against ischemic stroke and the organophosphorus nerve agent and chemical weapon, soman.ConclusionIn the light of its tolerability in AD clinical trials, PhenT is an agent that can be fast‐tracked for evaluation in not only civilian TBI, but also as a potentially protective agent in battlefield conditions where TBI and chemical weapon exposure are increasingly jointly occurring.
Evolution of antibiotic cross‐resistance and collateral sensitivity in Staphylococcus epidermidis using the mutant prevention concentration and the mutant selection window
Authors: Lozano‐Huntelman Natalie Ann , Singh Nina , Valencia Alondra , Mira Portia , Sakayan Maral , Boucher Ian , Tang Sharon , Brennan Kelley , Gianvecchio Crystal , Fitz‐Gibbon Sorel , Yeh Pamela 
Published: December 2019

AbstractIn bacteria, evolution of resistance to one antibiotic is frequently associated with increased resistance (cross‐resistance) or increased susceptibility (collateral sensitivity) to other antibiotics. Cross‐resistance and collateral sensitivity are typically evaluated at the minimum inhibitory concentration (MIC). However, these susceptibility changes are not well characterized with respect to the mutant prevention concentration (MPC), the antibiotic concentration that prevents a single‐step mutation from occurring. We measured the MIC and the MPC for Staphylococcus epidermidis and 14 single‐drug resistant strains against seven antibiotics. We found that the MIC and the MPC were positively correlated but that this correlation weakened if cross‐resistance did not evolve. If any type of resistance did evolve, the range of concentrations between the MIC and the MPC tended to shift right and widen. Similar patterns of cross‐resistance and collateral sensitivity were observed at the MIC and MPC levels, though more symmetry was observed at the MIC level. Whole‐genome sequencing revealed mutations in both known‐target and nontarget genes. Moving forward, examining both the MIC and the MPC may lead to better predictions of evolutionary trajectories in antibiotic‐resistant bacteria.
Numerical assessment of the loading of rolling contact fatigue cracks close to rail surface irregularities
Authors: Andersson Robin , Kabo Elena , Ekberg Anders 
Published: December 2019

AbstractRolling contact fatigue damage of railway rails in the form of squats, characterised by local depressions and cracks located at the rail surface, has been linked to the occurrence of local rail surface irregularities. This study concerns rolling contact fatigue cracks in the vicinity of fairly smooth surface irregularities, here denoted dimples. The influence of factors such as dimple geometry, cluster effects, and crack size is evaluated. To this end, dynamic vehicle–track simulations featuring realistic wheel and rail profiles are employed to characterise the dynamic impact during a wheel passage. The contact load in the vicinity of the dimples is then mapped onto a 3D finite element model of a rail section containing a crack in the rail head. The crack loading is finally quantified by multimodal stress intensity factors. The analyses establish that also shallow dimples might have a significant impact on the crack loading. This effect is increased for larger or multiple irregularities but decreases as the crack grows.