bluuebunny/crossref_metadata_2025_split huggingface dataset:
Számít-e a gyógyszer dózisa a túlérzékenységi reakciókban?
Authors: Jenei Kluch Lenke , Erdei Irén , Remenyik Éva , Surányi Éva , Bodnár Ferenc , Emri Gabriella , Szegedi Andrea 
Published: November 2020

Összefoglaló. Két fiatal nőbetegnél a valproátról lamotriginre
történő gyógyszerátállítás során a 3–4. héten influenzaszerű prodromalis
tüneteket követően toxikus epidermalis necrolysis (TEN), más néven
Lyell-szindróma alakult ki. Mindkét beteg 5 napja kezdődött bőr- és
nyálkahártyatünetekkel, kiterjedt hámleválást okozó hámnekrózissal került
felvételre a Debreceni Egyetem Bőrgyógyászati Klinikájának Égési Intenzív
Osztályára. Multidiszciplináris szupportív terápia mellett nagy dózisú szteroid-
és immunglobulin-terápiát alkalmaztunk. A 37 éves nőbetegnél 3 hét után a kórkép
fatális kimenetellel végződött. A 19 éves nőbeteg tünetei 4 hét intenzív terápia
után szövődményekkel gyógyultak. A TEN ritka, gyógyszer által okozott, életet
veszélyeztető, késői hiperszenzitivitási reakció. Patogenezisében a
gyógyszermolekula, a humán leukocytaantigén (HLA) I. osztályú molekula és a
T-sejt-receptor kóros interakciója szerepel. Kezelésében a legfontosabb a
kiváltó gyógyszer elhagyása, valamint az azonnal kezdett komplett szupportív
terápia alkalmazása. A specifikus kezelést illetően nincsenek egységes szakmai
irányelvek. A veszélyes gyógyszerek titrált bevezetése csökkentheti a kialakuló
hiperszenzitivitás súlyosságát, ezenfelül a beteg szoros követése és az adverz
tünetek korai felismerése javíthatja a TEN kimenetelét. Orv Hetil. 2020;
161(46): 1959–1965.
Summary. After switching from valproate to lamotrigine, on the
3rd–4th weeks, two young female patients developed flu-like prodromal symptoms,
followed by the development of toxic epidermal necrolysis (TEN), also known as
Lyell syndrome. Both patients were admitted to the Burn Intensive Care Unit of
the Department of Dermatology, University of Debrecen with skin and mucosa
symptoms; extensive epithelial death and detachment started 5 days earlier. In
addition to multidisciplinary supportive treatment, high-dose corticosteroid and
immunoglobulin therapy were administered. In the case of the 37-year-old female
patient, the disease resulted in a fatal outcome. The 19-year-old patient healed
with some sequelae. TEN is a rare, life-threatening delayed-type
hypersensitivity reaction caused by drugs. Its pathogenesis involves an
interaction between small-molecule drug, human leukocyte antigen class I
molecule and T-cell receptor. The most important treatment is immediate
withdrawal of potentially causative drugs and prompt application of supportive
therapy. There is no standard guidance on specific treatment. Slow dose
escalation of dangerous drugs can be beneficial in avoiding severe reactions,
furthermore, close patient follow-up and early detection of the possible adverse
reactions contribute to a more favourable outcome of TEN. Orv Hetil. 2020;
161(46): 1959–1965.
A paradigm shift in the concept of arrhythmogenic cardiomyopathy: expanding the clinical and genetic spectrum, new diagnostic criteria for left ventricular phenotypes
Authors: Vaikhanskaya T. G. , Sivitskaya L. N. , Kurushko T. V. , Rusak T. V. , Levdansky O. D. , Danilenko N. G. , Davydenko O. G. 
Published: November 2020

Recent multicenter studies using high-tech cardiac imaging and novel translational technologies have shown that cardiac fibrofatty replacement, characteristic of arrhythmogenic cardiomyopathy (ACM), is observed in both ventricles; left ventricular (LV) involvement may be minimal, on par with the right ventricle (RV), or dominant. In 2019, the Heart Rhythm Society (HRS) proposed a new approach to the assessment of arrhythmic and genetic diseases with the inclusion of new phenotypes — left-dominant ACM and biventricular ACM. In 2020, to improve the diagnosis of left ventricular phenotypes, European experts revised ACM criteria (based on the 2010 ITF criteria), which are called the Padua criteria.The presented article highlights the clinical and genetic aspects of the new concept and the difficulties in ACM diagnosis, the practical experience of using new diagnostic algorithm. To help practitioners, step-by-step differential diagnosis and risk stratification of right and left ventricular phenotypes are presented using clinical examples (leftdominant ACM with a pathogenic variant in the LMNA gene; right-dominant ACM associated with a desmoplakin gene mutation, with predominant RV and moderate LV involvement; and an isolated RV ACM associated with a mutation in the plakophilin 2 gene).
Next generation sequencing in sudden cardiac death (pilot study)
Authors: Maksimov V. N. , Ivanoshchuk D. E. , Orlov P. S. , Ivanova A. A. , Malyutina S. K. , Maksimova S. V. , Rodina I. A. , Khamovich O. V. , Novoselov V. P. , Voevoda M. I. 
Published: November 2020

Aim.To search for causal mutations in candidate genes responsible for the development of sudden cardiac death (SCD) in men who died under the age of 45.Materialandmethods.The SCD group (n=37) was formed using the criteria the World Health Organization and the European Society of Cardiology. Autopsy material was collected from men who died suddenly outside medical institutions and underwent forensic medical examination according to the standard protocol. Autopsy revealed no morphological changes that could explain sudden death. The mean age was 32,4±6,4 years. Genomic DNA was isolated from myocardial tissue using phenol-chloroform extraction. Clinical exome sequencing was performed. At first, we analyzed the results of sequencing of 24 genes, mutations in which lead to cardiovascular diseases associated with an increased risk of SCD:KCNQ1,KCNH2,SCN5A,AKAP9,ANK2,CACNA1C,CALM1,CALM2,CAV3,KCNE1,KNCJNE2,KCNE2,SCN4B,SNTA1,MYH2,APOB,KCNA5,TGFB3,NEB,PDX1,FLNC,PLEC,KCND3.Results.Of 37 samples, we revealed 13 probable pathogenic missense mutations in 9 samples (24,3%). Of 13 probable pathogenic variants, 5 were new.Conclusion.This pilot study provides following conclusions: it is necessary to continue molecular autopsy research in Russia; to increase the effectiveness of detecting causal mutations, it is necessary to reduce the age of patients with SCD included in the study; studying the families of deceased; cooperation of experienced specialists — forensic pathologist, laboratory geneticist, cardiologist.
TExpression of matrix metalloproteinases 1, 2, 9, 12 in xenogenic tissues of epoxy-crosslinked bioprosthetic heart valves explanted due to dysfunction
Authors: Kostyunin A. E. , Glushkova T. V. 
Published: November 2020

Aim. To study the expression patterns of matrix metalloproteinases (MMPs) -1, -2, -9, -12 in the leaflets of the epoxy-treated bioprostheses explanted due to dysfunction and to identify the pathways for the accumulation of these enzymes in the xenogenic tissues.Methods. 19 leaflets from seven epoxy-treated bioprostheses (Kemcor (n = 2), PeriCor (n = 2), UniLine (n = 2) and TiAra (n = 1)) explanted from the mitral or aortic positions during repeat heart valve replacements were included in a study. Sections for microscopic studies were cut on a standard rotary microtome. Cell typing and the expression of MMP-1, -2, -9, -12 were evaluated using immunohistochemical staining with the antibodies against PTPRC/CD45, CD68, neutrophil myeloperoxidase and the corresponding MMPs. Stained samples were examined by light microscopy.Results. Sporadic cell infiltrates, mainly composed of macrophages (PTPRC/CD45+, CD68+), were found in 17 leaflets from six explanted bioprostheses. Positive staining for MMP-1, -2, -9, -12 was colocalized with immune cell infiltrates. It is worth noting that MMP-9 staining was visualized even in the absence of cell infiltration, while more intense staining was found in the areas with a loose extracellular matrix. There were no signs of macrophage infiltration or MMP expression in xenotissues of pericardial bioprostheses failed due to thrombosis and explanted two days after implantation. However, a blood clot formed on its surface showed intense MMP-9 staining and included a large proportion of neutrophils positive for myeloperoxidase.Conclusion. Macrophages and other immune cells that infiltrate xenotissues of epoxy-treated bioprostheses are sources of MMP-1, -2, -9, -12. In addition, MMP-9 can diffuse into bioprosthetic valve leaflets from blood plasma of patients. Thus, MMPs deposition in xenotissues may contribute to the leaflet ruptures and calcifications leading to the development of bioprosthetic valve dysfunction.
Prevalence of geriatric syndromes in persons over 65 years: the first results of the EVCALIPT study
Authors: Tkacheva O. N. , Vorob’eva N. M. , Kotovskaya Yu. V. , Ostroumova O. D. , Chernyaeva M. S. , Silyutina M. V. , Chernov A. V. , Testova S. G. , Ovcharova L. N. , Selezneva E. V. 
Published: November 2020

Aim.To study the prevalence of geriatric syndromes and assess their relationship with senile asthenia in persons aged ³65 years living in Russian regions with different demographic, climatic and socio-economic characteristics.Material and methods.We examined 664 patients aged 65-107 years (mean age, 79±9 years; men, 25%) living in Moscow (n=365) and Voronezh (n=299). All patients underwent a comprehensive geriatric examination, which consisted of two stages: a survey with original questionnaire and an objective examination.Results.The prevalence of senile asthenia was 66,4%, including 47,4% in people aged 65-74, 71,1% — 75-84 years, and 82,8% — ³85 years (p for trend <0,001). Senile asthenia was associated with age (odds ratio (OR), 2,36; 95% confidence interval (CI), 1,89-2,93; p<0,001) and female sex (OR, 1,52; 95% CI 1,06-2,18; p=0,024). Patients with senile asthenia had a lower socioeconomic status. Also, close associations of senile asthenia with other geriatric syndromes (dementia, depression, vision and hearing impairment, incontinence, falls, high risk of falls, functional decline, failure to thrive) with OR from 1,32 to 7,22 were revealed.Conclusion.The first results of the EVCALIPT study indicate a high incidence of senile asthenia in persons aged ³65 years and its close association with other geriatric syndromes and socio-economic factors.
Piel virtual: Investigación Educativa Basada en Artes e Imagen Virtual
Authors: Gonzalez de la Torre Antonio , Roldán Ramírez Joaquín Javier 
Published: November 2020

Resumen
“Piel Virtual” es un taller educativo en Artes Visuales que utiliza la imagen virtual desde un enfoque a/r/tográfico. Utilizamos el video mapping sobre la piel humana para indagar las múltiples posibilidades creativas, artísticas y pedagógicas que tienen los entornos virtuales como espacios de creación de imágenes.
En toda actividad artística hay un propósito investigador siempre que se tenga en cuenta el factor de creación que implican (Muntané, M. D. C. G., Hernández, F. H., & López, H. J. P. (2006). Aunque dichos procesos y propósitos investigacionales necesitan un ámbito de difusión y unos modelos convencionales de formulación y difusión para permitir la actividad crítica y su validación por la comunidad académica. Biggs, M. (2003).
En nuestro taller de creación hemos trabajado a partir del trabajo del fotógrafo Daniel Oliver. Sus obras son fotografías de cuerpos con diversas formas de proyección lumínica. Se trata de fotografías que muestran volúmenes, formas, contornos anatómicos combinados con los múltiples efectos ópticos producidos por la luz y las imágenes que proyecta sobre los cuerpos. Se mezclan, así, volúmenes naturales con pieles virtuales, creando una sensación de profundidad sobre la piel y generando diálogos entre la luz que ilumina la escena y la luz que procede de las imágenes proyectadas. Los resultados de la práctica artística se muestran en forma de fotoensayos o de videocreaciones.
Por estos juegos y combinaciones, en la obra de Oliver, la imagen virtual es una herramienta de enorme versatilidad en la que lo digital se convierte en virtual.
El uso creativo de la imagen virtual a través TICs que giran en torno a las tecnologías de almacenamiento, procesamiento, recuperación y comunicación de la información a través de diferentes dispositivos electrónicos e informáticos. Belloch, C. (2012) asequibles en las aulas de Educación Artística ayudan en la construcción de metodologías que permiten a través de la experimentación fotografía, la videocreación y uso de plataformas digitales un encuentro fértil de enorme valor estético. Prácticas novedoras que desarrollan un diálogo a través de la luz, los espacios y el mensaje como un fin del medio.
Ensemble ShakeMaps for Magnitude 9 Earthquakes on the Cascadia Subduction Zone
Authors: Wirth Erin A. , Grant Alex , Marafi Nasser A. , Frankel Arthur D. 
Published: November 2020

AbstractWe develop ensemble ShakeMaps for various magnitude 9 (M 9) earthquakes on the Cascadia megathrust. Ground-shaking estimates are based on 30 M 9 Cascadia earthquake scenarios, which were selected using a logic-tree approach that varied the hypocenter location, down-dip rupture limit, slip distribution, and location of strong-motion-generating subevents. In a previous work, Frankel et al. (2018) used a hybrid approach (i.e., 3D deterministic simulations for frequencies &lt;1  Hz and stochastic synthetics for frequencies &gt;1  Hz) and uniform site amplification factors to create broadband seismograms from this set of 30 earthquake scenarios. Here, we expand on this work by computing site-specific amplification factors for the Pacific Northwest and applying these factors to the ground-motion estimates derived from Frankel et al. (2018). In addition, we use empirical ground-motion models (GMMs) to expand the ground-shaking estimates beyond the original model extent of Frankel et al. (2018) to cover all of Washington State, Oregon, northern California, and southern British Columbia to facilitate the use of these ensemble ShakeMaps in region-wide risk assessments and scenario planning exercises. Using this updated set of 30 M 9 Cascadia earthquake scenarios, we present ensemble ShakeMaps for the median, 2nd, 16th, 84th, and 98th percentile ground-motion intensity measures. Whereas traditional scenario ShakeMaps are based on a single hypothetical earthquake rupture, our ensemble ShakeMaps take advantage of a logic-tree approach to estimating ground motions from multiple earthquake rupture scenarios. In addition, 3D earthquake simulations capture important features such as strong ground-motion amplification in the Pacific Northwest’s sedimentary basins, which are not well represented in the empirical GMMs that compose traditional scenario ShakeMaps. Overall, our results highlight the importance of strong-motion-generating subevents for coastal sites, as well as the amplification of long-period ground shaking in deep sedimentary basins, compared with previous scenario ShakeMaps for Cascadia.
INTRODUCING JAVANESE CULTURE THROUGH SELECTED TEXTS IN EFL CLASS
Authors: Parangu Kaukabilla Alya 
Published: November 2020

The paper presents an overview of the research on teaching Javanese culture and describes the association between Javanese culture and English language teaching (ELT) through selected texts. A decisive question occurs in terms of ELT, whether to teach culture along with English. The implementation of selected text is one of the effective ways to encourage students to more appreciate and feel affection for their own culture. Since the native Javanese people obligates to be aware of their own culture. Using Javanese culture text means that the texts learned by the students are part of the Javanese original culture. Dealing with the text, the students will have a handle on the culture profoundly. To answer such an incomprehensible question, this article shows the relation about the connection among literature and studies. This research also discusses a theoretical frame based on the experts’ insights and opinions. To summarize, this research displays various viewpoints in relation to this topic, offers different practical studies, and reaches some valuable conclusions.
Impact of abortion law reforms on women’s health services and outcomes: a systematic review protocol
Authors: Ishola Foluso , Ukah Vivian , Nandi Arijit 
Published: November 2020

Abstract
BackgroundA country’s abortion law is a key component in determining the enabling environment for safe abortion. While restrictive abortion laws still prevail in most low- and middle-income countries (LMICs), many countries have reformed their abortion laws, with the majority of them moving away from an absolute ban. However, the implications of these reforms on women’s access to and use of health services, as well as their health outcomes, is uncertain. First, there are methodological challenges to the evaluation of abortion laws, since these changes are not exogenous. Second, extant evaluations may be limited in terms of their generalizability, given variation in reforms across the abortion legality spectrum and differences in levels of implementation and enforcement cross-nationally. This systematic review aims to address this gap. Our aim is to systematically collect, evaluate, and synthesize empirical research evidence concerning the impact of abortion law reforms on women’s health services and outcomes in LMICs.MethodsWe will conduct a systematic review of the peer-reviewed literature on changes in abortion laws and women’s health services and outcomes in LMICs. We will search Medline, Embase, CINAHL, and Web of Science databases, as well as grey literature and reference lists of included studies for further relevant literature. As our goal is to draw inference on the impact of abortion law reforms, we will include quasi-experimental studies examining the impact of change in abortion laws on at least one of our outcomes of interest. We will assess the methodological quality of studies using the quasi-experimental study designs series checklist. Due to anticipated heterogeneity in policy changes, outcomes, and study designs, we will synthesize results through a narrative description.DiscussionThis review will systematically appraise and synthesize the research evidence on the impact of abortion law reforms on women’s health services and outcomes in LMICs. We will examine the effect of legislative reforms and investigate the conditions that might contribute to heterogeneous effects, including whether specific groups of women are differentially affected by abortion law reforms. We will discuss gaps and future directions for research. Findings from this review could provide evidence on emerging strategies to influence policy reforms, implement abortion services and scale up accessibility.Systematic review registrationPROSPERO CRD42019126927
Colonisation by native shrubby species enhances the carbon storage capacity of exotic mangrove monocultures
Authors: He Ziying , Sun Huaye , Peng Yisheng , Hu Zhan , Cao Yingjie , Lee Shing Yip 
Published: November 2020

Abstract
Background：The exotic Sonneratia apetala and native Kandelia obovata have been widely planted in mangrove afforestation and reforestation programmes in China. However, their capacity for carbon sequestration is still controversial.Results: The total vegetation biomass was highest in K. obovata monoculture, followed by the mixed forest and lowest in S. apetala monoculture. This difference is attributed to the difference in stem density. This trend also applies to total vegetation and soil organic carbon storages.Conclusions: Contrary to the original expectation, shrubby native K. obovata may be preferred to exotic S. apetala for mangrove reforestation/afforestation. It is recommended the carbon storage capacity of the existing S. apetala plantation may be enhanced by introducing native mangrove species. As a rehabilitation option, the establishment of mixed plantations with different stem densities could improve the capacity for carbon storage of mono-specific plantations of exotic species.
Shallow slow earthquakes to decipher future catastrophic earthquakes in the Guerrero seismic gap.
Authors: Plata-Martínez Raymundo , Ide Satoshi , Shinohara Masanao , Mortel Emmanuel Soliman Garcia , Mizuno Naoto , Ramirez Luis Antonio Dominguez , Taira Taka’aki , Yamashita Yusuke , Toh Akiko , Yamada Tomoaki , Pérez Jorge Arturo Real , Husker Allen Leroy , Atienza Victor Manuel Cruz , Ito Yoshihiro 
Published: November 2020

Abstract
The Guerrero seismic gap is presumed to be a major source of seismic and tsunami hazard along the Mexican subduction zone. Until recently, there were limited observations to describe the shallow portion of the plate interface in Guerrero. For this reason, we deployed offshore instrumentation to gain new seismic data and identify the extent of the seismogenic zone inside the Guerrero gap. We discovered episodic shallow tremors and potential slow slip events which, together with repeating earthquakes, seismicity, residual gravity and residual bathymetry suggest that a portion of the shallow plate interface in the Guerrero seismic gap undergoes stable slip. This mechanical condition may not only explain the long return period of large earthquakes with origins inside the Guerrero seismic gap, but also reveal why the rupture from past M<8 earthquakes on adjacent megathrust fault segments did not propagate into the gap to encompass a larger slip area. Nevertheless, a large enough earthquake initiating nearby could rupture through the entire Guerrero seismic gap if driven by dynamic rupture effects.
Gualou Guizhi Granule Suppresses LPS-induced Inflammatory Response of Microglia and Protects Against Microglial-Mediated Neurotoxicity in HT22 via Akt/NF-κB Signaling Pathways
Authors: Zhang Yuqin , Liu Yaojun , Fan Liming , Nan Lihong , Xu Wei , Chu Kedan , Yan Guohong , Lin Yu 
Published: November 2020

Abstract
Background Neuroinflammation plays a crucial part in the commence and advancement of ischemic stroke. Gualou Guizhi Granule (GLGZG) is known to exhibit well neuroprotective effect, but it is not known whether GLGZG can regulate inflammatory process at the cellular level in BV2 microglia cells and protect against microglial-mediated neurotoxicity in neurons. Herein, we aimed to investigate the anti-inflammatory effects of GLGZG on BV2 microglia cells and protection against microglial-mediated neurotoxicity in neurons. Methods Cell model of neuroinflammation was constructed by lipopolysaccharide (LPS) to observe the effect of GLGZG in the presence or absence of GLGZG. The production of nitric oxide (NO), inflammatory mediators were detected. Moreover, potential mechanisms associated with anti-inflammatory effect, such as inhibition of microglial activation, the nuclear factor kappa B (NF-κB) were also investigated. In addition, to prove whether GLGZG protects against microglial-mediated neurotoxicity, neuronal HT22 cells were cultured in conditioned medium. And cell survivability, neuronal apoptosis of HT22 were evaluated. Results It was found that a main regulator of inflammation, NO, is suppressed by GLGZG in BV2 microglial cells. Moreover, GLGZG dose-dependently decreased the mRNA and protein levels of inducible NO synthase (iNOS) in LPS-stimulated BV2 cells. Additionally, GLGZG inhibited the expression and secretion of proinflammatory cytokines in BV2 microglial cells. And, GLGZG inhibited LPS-activated nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) in BV2 microglial cells at the intracellular level. GLGZG negatively affected Akt phosphorylation: phosphorylated forms of Akt decreased. To check whether GLGZG protects against microglial-mediated neurotoxicity, neuronal HT22 cells were incubated in the conditioned medium. GLGZG showed a neuroprotective effect by promoting cell survivability, suppressing neuronal apoptosis. Conclusions GLGZG exerted its potential effects on suppressing inflammatory responses in LPS-induced BV2 cells by attenuating NF-κB and Akt pathways. In addition, GLGZG could protect against microglial-mediated neurotoxicity in HT22.