bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emergence, time and sociality: comparing conceptions of process ontology
Authors: Baggio Guido 
Published: May 2020

Abstract
The paper focuses on a comparison between Lawson’s and Mead’s processual ontologies and more specifically on their conceptions of emergence. The first aim of the article is to highlight elements of similarity between their conceptions of social reality. It also aims to show, on the one hand, that Mead’s bio-social account of the emergent can help to interpret the dynamic process of emergence of both the social realm and agents’ identities (as described by Lawson) from a dynamic non-reductive naturalistic perspective; on the other hand, it shows how Lawson’s category of ‘social positioning’ can complement Mead’s ontogenetic explanation of changing social positions and the definition of ‘multiple selves’. By carefully considering the key elements of Lawson’s and Mead’s projects, it is, in fact, possible to understand better the meaning of a commitment to an updated processual ontology. In considering connections with classical pragmatic authors, it can be demonstrated that there are significant overlaps regarding the respective ways of considering the emergent. This offers a chance to understand more deeply how both pragmatism and Cambridge social ontology can together become part of the wider contemporary philosophical debate. In fact, Mead’s attempted synthesis between social and physical theories would help to highlight the common and complementary aspects linking what can be defined as his and Lawson’s ‘processual ontologies’.
Puberty and oestral cycle length in captive female jaguars Panthera onca
Authors: Viau Priscila , Rodini Débora Cattaruzzi , Sobral Gisela , Martins Gabriela Siqueira , Morato Ronaldo Gonçalves , de Oliveira Claudio Alvarenga 
Published: May 2020

Abstract
Habitat loss and fragmentation have been leading jaguars to constant conflicts with humans, and as a result, jaguar populations have been declining over the last decades. Captive breeding is often a tool for species conservation, and it is not different for jaguars. However, success is far from optimal due to the lack of basic knowledge about species’ reproductive biology. In the present study, we assessed gonadal hormonal profiles of natural oestral cycles and puberty and compared our data to those of other wild felids. We collected faecal samples from two to seven times per week for 18 months from two adults and three pre-pubertal females. We defined baseline levels for progestins and oestrogens in order to estimate oestrous cycle length and age at puberty. We compared our data with 16 other species through generalized linear model, using weight and genus as two explanatory variables. Cycle length was 38.28 ± 2.52 days, ranging from 25 to 44 days, while sexual maturity was attained within 22 months. Due to our analysis of both hormonal and behavioural data, there is a variation between this research from other studies that employed only behavioural observations. Such difference may be caused by the absence of behavioural oestrous at the peri-pubertal period. When compared to wild felids of similar size, puberty and oestral cycle durations of the jaguar females fell within the same range. Our modelling showed that age at maturity was influenced mostly by size and only Leopardus partially explained the observed variation. Conversely, oestral cycle length did not differ among genera or size categories. Our study adds to the body literature in the reproductive endocrinology of wild felids, and because female gametes are more challenging to collect and preserve, a strong understanding on the female reproductive physiology is essential to assisted reproduction and wild population viability assessment.
Impact of arterio–ventricular interaction on first-phase ejection fraction in aortic stenosis
Authors: Einarsen Eigir , Hjertaas Johannes J , Gu Haotian , Matre Knut , Chowienczyk Philip J , Gerdts Eva , Chambers John B , Saeed Sahrai 
Published: May 2020

Abstract

Aims
First-phase ejection fraction (EF1), the EF at the time to peak aortic jet velocity, has been proposed as a novel marker of peak systolic function in aortic stenosis (AS). This study aimed to explore the association of myocardial contractility and arterial load with EF1 in AS patients.

Methods and results
Data from a prospective, cross-sectional study of 114 patients with mild, moderate, and severe AS with preserved left ventricular EF (&gt;50%) were analysed. EF1 was measured as the volume change from end-diastole to the time that corresponded to peak aortic jet velocity. Myocardial contractility was assessed by strain rate measured by speckle tracking echocardiography. Arterial stiffness was assessed by central pulse pressure/stroke volume index ratio (PP/SVi). The total study population included 48% women, median age was 73 years, and mean peak aortic jet velocity was 3.47 m/s. In univariable linear regression analyses, lower EF1 was associated with higher age, higher peak aortic jet velocity, lower global EF, lower global longitudinal strain, lower strain rate, and higher PP/SVi. There was no significant association between EF1 and heart rate or sex. In multivariable linear regression analysis, EF1 was associated with lower strain rate and higher PP/SVi, independent of AS severity. Replacing PP/SVi by valvular impedance did not change the results.

Conclusion
In patients with AS, reduced myocardial contractility and increased arterial load were associated with lower EF1 independent of the severity of valve stenosis.
Sex-specific relationships between patterns of ventricular remodelling and clinical outcomes
Authors: Miller Robert J H , Mikami Yoko , Heydari Bobak , Wilton Stephen B , James Matthew T , Howarth Andrew G , White James A , Lydell Carmen P 
Published: May 2020

Abstract

Aims
Left ventricular hypertrophy (LVH) is the most common form of myocardial remodelling and predicts adverse outcomes in patients with coronary artery disease (CAD). However, sex-specific prevalence and prognostic significance of LVH patterns are poorly understood. We investigated the sex-specific influence of LVH pattern on clinical outcomes in patients undergoing cardiovascular magnetic resonance (CMR) and coronary angiography following adjustment for co-morbidities including CAD burden.

Methods and results
Patients undergoing CMR and coronary angiography between 2005 and 2013 were included. Volumetric measurements of left ventricular (LV) mass with classification of concentric vs. eccentric remodelling patterns were determined from CMR cine images. Multivariable Cox analysis was performed to assess independent associations with the primary outcome of all-cause mortality. In total, 3754 patients were studied (mean age 59.3 ± 13.1 years), including 1039 (27.7%) women. Women were more likely to have concentric remodelling (8.1% vs. 2.1%, P &lt; 0.001), less likely to have eccentric hypertrophy (15.1% vs. 26.8%, P &lt; 0.001) and had a similar prevalence of concentric hypertrophy (6.1 vs. 5.2%, P = 0.296) compared to men. At a median follow-up of 3.7 years, 315 (8.4%) patients died. Following adjustment including CAD burden, concentric hypertrophy was associated with increased all-cause mortality in women [adjusted hazard ratio (HR) 3.48, P &lt; 0.001] and men (adjusted HR 2.57, P &lt; 0.001). Eccentric hypertrophy was associated with all-cause mortality only in women (adjusted HR 1.78, P = 0.047).

Conclusion
Patterns of LV remodelling differ by sex and LVH and provides prognostic information in both men and women. Our findings support the presence of sex-specific factors influencing LV remodelling.
Jobs, News and Reoffending after Incarceration
Authors: Galbiati Roberto , Ouss Aurélie , Philippe Arnaud 
Published: May 2020

Abstract
We study how local labour market conditions and information about job availability affect recidivism after incarceration. We exploit daily variations in the quality of the labour market at the time of release from prison. We combine individual-level administrative data on former inmates in France to county-level daily data on new job vacancies, and on newspaper coverage of job creation and destruction. Our analysis provides two new findings. First, media coverage of job creation reduces recidivism, suggesting that policies promoting access to information about employment opportunities can contribute to reducing recidivism. Second, we show that there is heterogeneity in what kinds of jobs affect recidivism: in France, former inmates do not respond to overall job creation, but better opportunities in manufacturing jobs at release reduce recidivism rates.
Uncertainty quantification in time-lapse seismic imaging: a full-waveform approach
Authors: Kotsi M , Malcolm A , Ely G 
Published: May 2020

SUMMARY
Time-lapse seismic monitoring using full-wavefield methods aims to accurately and robustly image rock and fluid changes within a reservoir. These changes are typically small and localized. Quantifying the uncertainty related to these changes is crucial for decision making, but traditional methods that use pixel by pixel uncertainty quantification with large models are computationally infeasible. We exploit the structure of the time-lapse seismic problem for fast wavefield computations using a numerically exact local acoustic solver. This allows us to perform a Bayesian inversion using a Metropolis–Hastings algorithm to sample our posterior distribution. We address the well-known dimensionality problem in global optimization using an image compression technique. We run our numerical experiments using a single shot and a single frequency, however we show that various frequencies converge to different local minima. In addition, we test our framework for both uncorrelated and correlated noise, and we retrieve different histograms for each noise type. Through our numerical examples we show the importance of defining quantities of interest in order to setup an appropriate uncertainty quantification framework involving choosing the number of degrees of freedom and model parametrization that best approximate the problem. To our knowledge, there is no work in the literature studying the time-lapse problem using stochastic full-waveform inversion.
Whole exome sequencing in patients with Williams–Beuren syndrome followed by disease modeling in mice points to four novel pathways that may modify stenosis risk
Authors: Parrish Phoebe C R , Liu Delong , Knutsen Russell H , Billington Charles J , Mecham Robert P , Fu Yi-Ping , Kozel Beth A 
Published: May 2020

AbstractSupravalvular aortic stenosis (SVAS) is a narrowing of the aorta caused by elastin (ELN) haploinsufficiency. SVAS severity varies among patients with Williams–Beuren syndrome (WBS), a rare disorder that removes one copy of ELN and 25–27 other genes. Twenty percent of children with WBS require one or more invasive and often risky procedures to correct the defect while 30% have no appreciable stenosis, despite sharing the same basic genetic lesion. There is no known medical therapy. Consequently, identifying genes that modify SVAS offers the potential for novel modifier-based therapeutics. To improve statistical power in our rare-disease cohort (N = 104 exomes), we utilized extreme-phenotype cohorting, functional variant filtration and pathway-based analysis. Gene set enrichment analysis of exome-wide association data identified increased adaptive immune system variant burden among genes associated with SVAS severity. Additional enrichment, using only potentially pathogenic variants known to differ in frequency between the extreme phenotype subsets, identified significant association of SVAS severity with not only immune pathway genes, but also genes involved with the extracellular matrix, G protein-coupled receptor signaling and lipid metabolism using both SKAT-O and RQTest. Complementary studies in Eln+/−; Rag1−/− mice, which lack a functional adaptive immune system, showed improvement in cardiovascular features of ELN insufficiency. Similarly, studies in mixed background Eln+/− mice confirmed that variations in genes that increase elastic fiber deposition also had positive impact on aortic caliber. By using tools to improve statistical power in combination with orthogonal analyses in mice, we detected four main pathways that contribute to SVAS risk.
Modelling of energy and exergy analysis of ORC integrated systems in terms of sustainability by applying artificial neural network
Authors: Utlu Zafer , Tolon Mert , Karabuga Arif 
Published: May 2020

Abstract
The present study focuses on the organic Rankine cycle (ORC) integrated into an evacuated tube heat pipe (ETHP), whose systems are an alternative solar energy system to low-efficiency planary collectors. In this work, a detailed thermodynamic and artificial neural network (ANN) analysis was conducted to evaluate the solar energy system. One of the key parameters of sustainable approaches focused on exergy efficiency is application of thermal engineering. In addition to this, sustainable engineering approaches nowadays are a necessity for improving the efficiency of all of the engineering research areas. For this reason, the ANN model is used to forecast different types of energy efficiency problems in thermodynamic literature. The examined system consists of two main parts such as the ETHP system and the ORC system used for thermal energy production. With this system, it is aimed to evaluate energy and exergy analysis results by the ANN method in the case of integrating the ORC system to ETHP, which is one of the planar collectors suitable for the roofs of the buildings. Within the scope of this study, the exergy efficiency was evaluated on the developed ANN algorithm. The effect rates of parameters such as pressure, temperature and ambient temperature affecting the exergy efficiency of ORC integrated ETHP were calculated. Ambient temperature was found to be the most influential parameter on exergy efficiency. The exergy efficiency of the whole system has been calculated as ~23.39%. The most suitable BPNN architecture for this case study is recurrent networks with dampened feedback (Jordan–Elman nets). The success rate of the developed BPNN model is 95.4%.
Principles of Large-scale Evidence Generation and Evaluation across a Network of Databases (LEGEND)
Authors: Schuemie Martijn J , Ryan Patrick B , Pratt Nicole , Chen RuiJun , You Seng Chan , Krumholz Harlan M , Madigan David , Hripcsak George , Suchard Marc A 
Published: May 2020

Abstract
Evidence derived from existing health-care data, such as administrative claims and electronic health records, can fill evidence gaps in medicine. However, many claim such data cannot be used to estimate causal treatment effects because of the potential for observational study bias; for example, due to residual confounding. Other concerns include P hacking and publication bias.
In response, the Observational Health Data Sciences and Informatics international collaborative launched the Large-scale Evidence Generation and Evaluation across a Network of Databases (LEGEND) research initiative. Its mission is to generate evidence on the effects of medical interventions using observational health-care databases while addressing the aforementioned concerns by following a recently proposed paradigm. We define 10 principles of LEGEND that enshrine this new paradigm, prescribing the generation and dissemination of evidence on many research questions at once; for example, comparing all treatments for a disease for many outcomes, thus preventing publication bias. These questions are answered using a prespecified and systematic approach, avoiding P hacking. Best-practice statistical methods address measured confounding, and control questions (research questions where the answer is known) quantify potential residual bias. Finally, the evidence is generated in a network of databases to assess consistency by sharing open-source analytics code to enhance transparency and reproducibility, but without sharing patient-level information.
Here we detail the LEGEND principles and provide a generic overview of a LEGEND study. Our companion paper highlights an example study on the effects of hypertension treatments, and evaluates the internal and external validity of the evidence we generate.
Role ofN-Acetylcysteine in the Treatment of Acute Nonacetaminophen, Nonalcoholic and Nonviral Hepatitis: A Meta-analysis
Authors: Aljohani Waleed , Chan Brian Pak Ho , Yaghoobi Mohammad 
Published: May 2020

AbstractIntroductionN-acetylcysteine (NAC) has been extensively investigated for the use in acetaminophen and alcoholic hepatitis and is indicated in acetaminophen overdose. Studies assessing the effect of NAC on other forms of acute hepatitis in adult patients are limited and therefore here we aimed at evaluating the effect of NAC on survival in nonacetaminophen, nonalcoholic and nonviral hepatitis in adults.MethodsA comprehensive literature search up to September 2019 was completed for randomized controlled trials (RCTs) comparing NAC to placebo in the management of acute nonacetaminophen, nonalcoholic and nonviral hepatitis. Studies with insufficient data, non-RCT or nonprospective design, paediatric studies and studies with no comparator were excluded. Study selection, quality assessment and data extraction were independently performed by two co-authors. Primary outcome was survival. Secondary outcomes were an increase in infection rate. We used random model Mantel–Haenszel meta-analysis with Cochrane risk of bias to assess the quality of included studies. The recommendation was presented using the GRADE framework.ResultsSeven out of 42 retrieved studies were included. Study population included patients with post-liver transplant, postsurgical, hypoxia-induced, ischemic and other nonalcoholic hepatitis. There was no difference in overall survival between NAC and placebo (odds ratio [OR] 0.95 [0.55 to 1.62]) in seven studies including 1033 patients. Furthermore, there was no difference in the rate of infection between NAC and placebo (OR 0.87 [0.43 to 1.79]). Random model analysis was used to adjust the effect of statistically significant heterogeneity in both analyses (P = 0.02). Lack of blinding in one study was found as a possible source of heterogeneity.ConclusionsNAC does not improve overall survival or the rate of infection in patients with acute nonacetaminophen, nonalcoholic and nonviral hepatitis as compared to placebo and should not be recommended in such setting which may even delay a transplant evaluation (level of evidence: 2a, GRADE of recommendation: B).
Laboratory Methods for Rearing Horn Flies (Diptera: Muscidae)
Authors: Holderman Chris J , Sanchez-Sandoval Ulises A , Ramirez Jovannah , Smythe Brandon G 
Published: May 2020

AbstractThe horn fly, Haematobia irritans (L.), is an obligate hematophagous ectoparasite of cattle, and one of the most important pests of cattle causing unrealized gains or losses in meat and milk production. The present study describes the difficulties that arise when research programs have attempted to maintain this pest, both on-host and off-host, in a laboratory environment. Suggestions aimed at assisting future researchers in successfully colonizing horn flies in the laboratory are provided.
Wolbachia (Rickettsiales: Alphaproteobacteria) Infection in the Leafhopper Vector of Sugarcane White Leaf Disease
Authors: Wangkeeree Jureemart , Tewaruxsa Panida , Roddee Jariya , Hanboonsong Yupa 
Published: May 2020

AbstractWolbachia is a maternally inherited bacterium ubiquitous in insects that has attracted interest as a prospective insect pest-control agent. Here, we detected and characterized Wolbachia in the leafhoppers Matsumuratettix hiroglyphicus (Matsumura) (Cicadellidae: Hemiptera) and Yamatotettix flavovittatus Matsumura (Cicadellidae: Hemiptera), insect vectors of the phytoplasma that cause white leaf disease in sugarcane. The 16S rRNA and wsp gene markers revealed that Wolbachia was not present in the M. hiroglyphicus but naturally occurs in Y. flavovittatus. Additionally, the infection rates in adult leafhoppers ranged from 0 to 100% depending on geographic location. Moreover, Wolbachia was detected in the eggs and first- to fifth-instar nymphs of Y. flavovittatus. A phylogenic tree of Wolbachia indicated that it resided in the monophyletic supergroup B clade and clustered in the Ori subgroup. Furthermore, fluorescence in situ hybridization revealed that Wolbachia localized to the egg apices, randomly distributed in the egg cytoplasm, and was concentrated in the nymph and adult bacteriomes, as well as occasional detection in the thorax and abdomen. To the best of our knowledge, the present study is the first to demonstrate the prevalence of Wolbachia in the leafhopper Y. flavovittatus. The obtained results would provide useful information for the future development of Wolbachia as a biological control agent for the leafhopper vectors.
Clinical and Epidemiological Features of a Family Cluster of Symptomatic and Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Authors: Wolf Gerhard K , Glueck Thomas , Huebner Johannes , Muenchhoff Maximilian , Hoffmann Dieter , French Lars E , Keppler Oliver T , Protzer Ulrike 
Published: May 2020

Abstract
In a family experiencing coronavirus disease 2019, the parents and 2 children aged 2 and 5 years became infected but the youngest child was not infected. Both children initially shed infectious virus, but cleared the virus after 5 to 6 days in the nasopharynx. However, viral RNA was continuously detected in the children’s stool for more than 4 weeks.
Rings and arcs around evolved stars – II. The Carbon Star AFGL 3068 and the Planetary Nebulae NGC 6543, NGC 7009, and NGC 7027
Authors: Guerrero M A , Ramos-Larios G , Toalá J A , Balick B , Sabin L 
Published: May 2020

ABSTRACT
We present a detailed comparative study of the arcs and fragmented ring-like features in the haloes of the planetary nebulae (PNe) NGC 6543, NGC 7009, and NGC 7027 and the spiral pattern around the carbon star AFGL 3068 using high-quality multi-epoch HST images. This comparison allows us to investigate the connection and possible evolution between the regular patterns surrounding AGB stars and the irregular concentric patterns around PNe. The radial proper motion of these features, ≃15 km s−1, are found to be consistent with the AGB wind and their linear sizes and interlapse times (500–1900 yr) also agree with those found around AGB stars, suggesting a common origin. We find evidence using radiative-hydrodynamic simulations that regular patterns produced at the end of the AGB phase become highly distorted by their interactions with the expanding PN and the anisotropic illumination and ionization patterns caused by shadow instabilities. These processes will disrupt the regular (mostly spiral) patterns around AGB stars, plausibly becoming the arcs and fragmented rings observed in the haloes of PNe.