bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in Gender Disparities in Authorship of Arthroplasty Research
Authors: Xu Raylin F. , Varady Nathan H. , Chen Antonia F. 
Published: August 2020

Background:
Despite efforts to address gender disparities in medicine, female representation in orthopaedics lags behind that of other fields, and little work has evaluated gender disparities within the subspecialty of arthroplasty surgery. The objective of this study was to analyze female authorship trends in arthroplasty research from 2002 to 2019.

Methods:
Articles published from 2002 to 2019 in 12 clinical orthopaedic and arthroplasty journals were extracted from PubMed. Articles that provided the full name of the first author and contained the terms “arthroplasty,” “hip replacement,” “knee replacement,” or “joint replacement” in the title and/or as keywords were analyzed. The gender of the author was determined with the validated Genderize algorithm, and publication trends were analyzed over time. Descriptive and comparative statistics were computed, and logistic regression was used to evaluate gender trends.

Results:
From 2002 to 2019, 14,692 articles met the inclusion criteria, and the gender of 63,628 authors was identified. There were 23,626 unique authors; 4,003 (16.9%) were women and 19,623 (83.1%) were men. Female involvement in arthroplasty publications increased from 11.1% in 2002 to 12.6% in 2019 (p < 0.001), and the percentage of female first authors increased from 5.0% in 2002 to 11.3% in 2019 (p < 0.001). Critically, however, the proportion of women as senior authors significantly declined from 8.5% in 2002 to 6.2% in 2019 (p < 0.001). From our analysis of U.S. publications with physician senior authors, the proportion of female senior authors remained relatively stable from 1.7% in 2002 to 2.4% in 2019 without a significantly increasing trend (p = 0.88). Overall, on average, women published a mean (and 95% confidence interval) of 1.9 ± 0.1 publications, while men published 2.9 ± 0.1 publications (p < 0.001). The proportion of female senior authors in arthroplasty publications (6.6%) was lower than that of other orthopaedic subspecialties such as sports medicine (9.2%), spine (13.6%), and foot and ankle (13.1%).

Conclusions:
While overall female representation and first authorship in arthroplasty literature have increased over time, the paucity of women in senior author roles remains troubling. Future studies should examine why the proportion of women publishing in arthroplasty remains lower than that in most other orthopaedic subspecialties.
Long-Term Assessment of Highly Cross-Linked and Compression-Molded Polyethylene Inserts for Posterior Cruciate-Substituting TKA in Young Patients
Authors: Kim Young-Hoo , Park Jang-Won 
Published: August 2020

Abstract:
The purpose of the present study was to determine the long-term clinical and radiographic results, survival rate, prevalence of osteolysis, and prevalence of fracture of the tibial polyethylene insert following total knee arthroplasty (TKA). Three hundred patients (600 knees) were included in this follow-up study. The mean age of the patients (and standard deviation) was 60.3 ± 4.3 years, and the mean duration of follow-up was 13.2 years (range, 12 to 14 years). Revision of the TKA prosthesis was performed in 7 knees (2.3%) with a compression-molded polyethylene (CPE) tibial insert and 6 knees (2%) with a highly cross-linked polyethylene (HXLPE) tibial insert. The rate of survival at 14 years was 97.7% (95% confidence interval [CI], 94%-100%) in the CPE group and 98% (95% CI, 94%-100%) in the HXLPE group with reoperation for any reason as the end point. The rate of survival at 14 years was 98% (95% CI, 94%-100%) in both groups with reoperation for mechanical failure as the end point. No knee had osteolysis or fracture of the tibial polyethylene insert. There were no between-group differences.

Level of Evidence:
Therapeutic Level I. See Instruction for Authors for a complete description of levels of evidence.
Revision Elbow Arthroplasty Using a Proximal Ulnar Allograft with Allograft Triceps for Combined Ulnar Bone Loss and Triceps Insufficiency
Authors: Burnier Marion , Nguyen Ngoc Tram V. , Morrey Mark E. , O’Driscoll Shawn W. , Sanchez-Sotelo Joaquin 
Published: August 2020

Background:
When revision elbow arthroplasty is required in the presence of structural proximal ulnar bone loss and triceps insufficiency, structural ulnar bone-grafting and triceps reconstruction are both required to reconstruct the skeleton and to restore active extension. We have developed a technique utilizing a structural proximal ulnar allograft with its attached triceps as an allograft-prosthetic composite (APC) to provide reconstruction of the proximal ulnar bone and deficient extensor mechanism with the same allograft.

Methods:
Between 2010 and 2017, the senior author performed 10 revision elbow arthroplasties using a proximal ulnar allograft with its intact triceps tendon allograft. The allograft ulna was combined with an ulnar component in an APC fashion, whereas the remaining triceps was repaired to the triceps allograft. Indications for a revision surgical procedure included aseptic loosening in 4 elbows, periprosthetic ulnar fracture with component loosening in 2 elbows, and the second stage of a 2-stage reimplantation in 4 elbows. Two elbows also required humeral APCs due to associated structural humeral bone loss. Postoperatively, all elbows were immobilized in extension for 6 weeks. The mean follow-up time was 45 months (range, 24 to 76 months).

Results:
Revision elbow arthroplasty resulted in pain improvement in all elbows in a 10-point visual analog scale. The mean flexion-extension arc was 95°, the mean Mayo Elbow Performance Score was 76 points (range, 45 to 95 points), and the mean triceps strength score was 4. There were 6 reoperations: 3 for humeral loosening, 1 for deep infection, 1 for fracture of the ulnar allograft, and 1 for wound debridement and closure. For the 8 elbows with an intact ulnar reconstruction, no ulnar components were radiographically loose, and the ulnar graft was considered radiographically intact and healed in 8 elbows.

Conclusions:
Reconstruction of the proximal part of the ulna and triceps in failed elbow arthroplasties with structural ulnar bone loss can be effectively accomplished using a structural proximal ulnar allograft as an APC with the preserved triceps tendon for the extensor mechanism reconstruction, but the procedure is associated with an expected high reoperation rate, as is the case in complex revision elbow arthroplasty.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Discrimination of Nitrogen Sources in Karst Spring Contributing Areas Using a Bayesian Isotope Mixing Model and Wastewater Tracers (Florida, USA)
Authors: Canion Andy , Ransom Katherine M. , Katz Brian G. 
Published: August 2020

ABSTRACT
Many springs in Florida have experienced a proliferation of nuisance algae and alteration of trophic structure in response to increases in nitrate concentration concurrent with rapid population growth and land use intensification beginning in the mid-20th century. While loading targets and remediation plans have been developed by state agencies to address excess nitrogen inputs, further confirmation of the relative contribution of nitrogen sources to groundwater is necessary to optimize the use of resources when implementing projects to reduce nitrogen loads. In the present study, stable isotopes of nitrate and wastewater indicators were used to discriminate sources of nitrogen in wells and springs in central Florida. Sampling was performed in 50 wells at 38 sites and at 10 springs with varying levels of agriculture and urban development. Nitrate isotope values were used to develop Bayesian mixing models to estimate the probability distribution of the contributions of nitrate sources in wells. Prior probabilities for the fractional contribution of each source were adjusted based on land use and density of septic tanks. Sucralose and the Cl:Br mass ratio were used as confirmatory indicators of wastewater sources. In residential areas, mixing model results indicated that fertilizer or mixed fertilizer and wastewater (septic tank effluent and reuse water) were the primary sources, with sucralose detections corresponding to wells with elevated contributions from wastewater. Sources of nitrogen in pasture and field crop areas were primarily fertilizer and manure; however, model posterior distributions of δ15N indicated that manure sources may have been overpredicted. The present study demonstrates the utility of a multi-tracer approach to build multiple lines of evidence to develop locally relevant remediation strategies for nitrogen sources in groundwater.
Management of urinary tract infections what do doctors recommend and patients do? An observational study in German primary care
Authors: Gágyor Ildikó , Strube-Plaschke Stephanie , Rentzsch Katrin , Himmel Wolfgang 
Published: August 2020

Abstract
Background Uncomplicated urinary tract infections (UTIs) in women are usually managed in primary care with antibiotics. However, many women seem to prefer to handle UTI symptoms with nonsteroidal anti-inflammatory drugs (NSAIDs) and other remedies. The aim of this study was to compare UTI management as recommended by physicians with the patients’ management at home.Methods This prospective cohort study in German primary care is based on clinical data from local practices and patient questionnaires. Participating women completed a baseline data sheet in the practice; their urine sample was tested by a dipstick in the practice and cultured by a laboratory. The women reported treatment and symptom-related impairment on an eight-item symptom questionnaire daily for 7 days. Using growth curve models, we analysed the influence of time on the total severity score to examine how symptoms changed across days. We then examined whether symptom severity and symptom course differed between patients who took antibiotics or NSAIDs.Results A total of 120 women (mean age of 43.3 ± 16.6 years) were enrolled. The urine dipstick was positive for leucocytes in 92%, erythrocytes in 87%, and nitrites in 23%. Physicians prescribed antibiotics for 102 (87%) women and recommended NSAIDs in 14 cases. According to the women’s reports, only 60% (72/120) took antibiotics, while the remainder took NSAIDs and other remedies. Symptoms declined from day 0 to day 6, irrespective of whether women decided to take an antibiotic, NSAIDs, none or both, as confirmed by a significant curvilinear time effect (B = 0.06, SE = 0.005, p < .001). The symptom course, however, was moderated by taking antibiotics so that the change in symptom severity was somewhat more pronounced in women taking antibiotics (B = 0.06) than in the remainder (B = 0.04).Conclusion A substantial proportion of women did not follow their physicians’ treatment recommendations, and many used NSAIDs. All women had a good chance of recovery irrespective of whether they decided to take antibiotics. A sensitive listening to patient preferences in the consultation may encourage physicians to recommend and prescribe symptomatic treatment with NSAID more often than antibiotic medicines.
Catalytic hydrolysis of Dichlorodifluoromethane over MoO3/ZrO2 -TiO2&nbsp;solid acid
Authors: Li Zhiqian , Zhou Tong , Ren Guoqing , Tan Xiaofang , Jia Lijuan , Liu Tiancheng 
Published: August 2020

Abstract
The catalytic hydrolysis of Difluoro dichloromethane (CFC-12) by solid acid of MoO3/ZrO2-TiO2 calcined at different temperature had been studied. The effects of catalytic hydrolysis temperature and water vapor concentration on catalytic hydrolysis of CFC-12 were also studied. The results showed that catalytic hydrolysis rate of CFC-12 reached to 98.65 % at 400℃when the MoO3/ZrO2-TiO2 catalyst was calcined at 500℃ with a concentration of water vapor of 83.18%, and the main hydrolysis products were CO, CO2, HF and HCl. After 30 hours’ continuous reaction, the hydrolysis rate of CFC-12 was 65.34%. The XRD result reveals that the main phase of solid MoO3/ZrO2-TiO2 catalyst is the tetragonal Zr (MoO4)2with doped TiO2 of anatase.
Fingerfoods: a feasibility study to enhance fruit and vegetable consumption in Dutch patients with dementia in a nursing home
Authors: Visscher Annemijn , Battjes-Fries Marieke CE , de Rest Ondine van , Patijn Olga N , Lee Mascha van der , Wijma-Idsinga Nienke , Pot Gerda K , Voshol Peter 
Published: August 2020

Abstract
Background Eating problems are highly prevalent in older patients with dementia and as a consequence, these patients are at greater risk of becoming malnourished. Fingerfoods, snacks that can be picked with thumb and forefinger, could be used to counteract malnutrition in patients with dementia. The aim of this feasibility study was to evaluate whether providing fruit and vegetable rich fingerfoods in the form of recognizable and familiar snacks on top of the normal intake was feasible for both patients with dementia and caregivers as a means to increase patients’ nutritional status. Methods Institutionalised patients with dementia (N = 15, 93% female, mean age = 85 years) were included in this feasibility study in the Netherlands. The residents received their regular diet supplemented with fingerfoods, comprising quiches and cakes rich in fruit or vegetables, for 6 weeks. Daily fingerfood consumption together with compensation behaviour at dinner of residents was administered with a checklist and food diaries at the start and end of the intervention as dose delivered. Furthermore, caregivers were asked to fill out a feedback form at the end of the intervention to measure fidelity and appreciation of the intervention. Results Patients consumed on average 1.4 pieces (70 grams) of fingerfoods daily, containing 41 grams of fruit and/or vegetables. Fruit and vegetable consumption increased during the provision of the fingerfoods and the residents seemed not to compensate this intake during the rest of the day. The intervention was generally positively received by the majority of caregivers, depending on the type of fingerfood and state of the resident. Conclusion This feasibility study showed that providing recognizable fruit and vegetable rich fingerfoods to patients with dementia seems feasible for both patients and caregivers and could provide a pragmatic approach to enhance fruit and vegetable consumption and total food intake in institutionalized elderly. In an up-scaled study, effects of fingerfoods on nutritional status and quality of life should be investigated.
The influence of integrated geriatric outpatient clinics on the health care utility of older people
Authors: WEI YU-JU , Hsieh Cheng-Fang , Huang Yu-Ting , Huang Ming-Shyan , Fang Tzu-Jung 
Published: August 2020

Abstract
Background: The number of people aged greater than 65 years is growing in many countries. Taiwan will be a superaged society in 2026, and health care utilization will increase considerably. Our study aimed to evaluate the efficacy of the geriatric integrated outpatient clinic model for reducing health care utilization by older people. Methods: This was a retrospective case-control study. Patients aged greater than 65 years seen at the geriatric outpatient clinic (Geri-OPD) and non-geriatric outpatient clinic (non-Geri-OPD) at a single medical centre were age and sex matched. Data on the number of outpatient clinic visits, emergency department visits, hospitalizations and medical expenditures were collected during the first and second years. A subgroup analysis by Charlson comorbidity index (CCI) and older age (age≧80 years) was performed, and the results were compared between the Geri-OPD and non-Geri-OPD groups. Results: A total of 6723 patients were included (3796 women and 2927 men). The mean age was 80.42 ± 6.39 years. There were 1291 (19.2%) patients in the Geri-OPD group and 5432 (80.8%) patients in the non-Geri-OPD group. After one year of regular follow-up, the Geri-OPD patients showed a significant reduction in the types of drugs included in each prescription (5.62±10.85) and the number of clinic visits per year (18.18 ± 48.85) (P<0.01). After a two-year follow-up, the number of clinic visits, emergency department visits, and hospitalizations and the annual medical costs were still decreased in the Geri-OPD patients. The Geri-OPD patients had more comorbidities and a higher rate of health care utilization than the non-Geri-OPD patients. In the subgroup analysis, patients with more comorbidities (CCI≧2) and an older age (≧80 years) in the Geri-OPD group showed a significant reduction in health care utilization. The Geri-OPD patients also showed a significant decrease in medical utilization in the second year compared with the non-Geri-POD patients. Conclusion: The Geri-OPD reduced medical costs, the number of drugs prescribed, and the frequency of outpatient clinic visits, emergency department visits and hospitalizations in older patients with complicated conditions. The effect was even better in the second year.
Prevalence, antimicrobial susceptibility pattern, and associated factors of Salmonella and Shigella among food handlers in Adigrat University student’s cafeteria, Northern Ethiopia, 2018
Authors: Legese Haftom , Kahsay Tsega , Gebrewahd Aderajew , Berhe Brhane , Fseha Berhane , Tadesse Senait , Gebremariam Guesh , Negash Hadush , Mardu Fitsum , Tesfay Kebede , Adhanom Gebre 
Published: August 2020

Abstract
Background: Food handlers play a significant role in the transmission of foodborne infections. Salmonella and Shigella are the most common foodborne pathogens and their infections are a major public health problem globally. Thus, this study aimed to determine the prevalence, antimicrobial susceptibility patterns, and associated factors of Salmonella and Shigella colonization among food handlers.Methodology: A cross-sectional study was conducted from March to August 2018 at Adigrat University student cafeteria, Northern Ethiopia. Data on socio-demographic and associated factors were collected using a structured questionnaire. Fresh stool samples were collected from 301 food handlers and transported to Adigrat University Microbiology Laboratory. Bacterial isolation and antimicrobial susceptibility test were performed using standard bacteriological methods. Data analysis was performed using SPSS version 22 and P < 0.05 where a corresponding 95% confidence interval was considered statistically significant.Results: A total of 301 food handlers were included in this study. The majority of study participants were females 265 (88.0 %). About 22 (7.3%) and 11 (3.7%) of food handlers were found to be positive for Salmonella and Shigella respectively. Hand washing after using a bathroom with water only, no hand washing after using the bathroom, no hand washing after touching dirty materials, no hand washing before food handling, and untrimmed fingernails were significant associated factors identified. None of the Salmonella and Shigella isolates were sensitive to ampicillin, yet low resistance against chloramphenicol, ceftriaxone, and ciprofloxacin was found. Conclusion: The present study revealed that the prevalence of Salmonella and Shigella among food handlers was 22 (7.3%) and 11 (3.7%) respectively. Such colonized food handlers can contaminate food, and drinks and could serve as a source of infection to consumers. This indicates that there is a need for strengthened infection control measures to prevent Salmonella and Shigella transmission in the students’ cafeteria.
A novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells
Authors: Gao Fan , Cai Ye , Tang Lu , Wu Chun-Lin , Cao Huifen , Xu Dongyang , Salazar-García Lorena , Han Xueer , Wang Fang , Ricciardi Natalie , Wahlestedt Thor , Cai DingDing , Wang Huifang , Chin Mario P. S. , Timmons James A. , Wahlestedt Claes , Kapranov Philipp 
Published: August 2020

Abstract
Abstract Single strand breaks (SSBs) represent the major form of DNA damage, yet no technique exists to map these lesions genome-wide with nucleotide-level precision. Herein, we present a method, termed SSiNGLe, and demonstrate its utility to explore the distribution and dynamic changes of genome-wide SSBs in response to different biological and environmental stimuli. We validate SSiNGLe using two very distinct sequencing techniques and apply it to derive global profiles of SSBs in different biological states. Strikingly, we show that patterns of SSBs in the genome are non-random, specific to different biological states, enriched in regulatory elements, exons, introns, specific types of repeats and exhibit differential preference for the template strand between exons and introns. Furthermore, we show that breaks likely contribute to naturally occurring sequence variants. Finally, we demonstrate strong links between SSB patterns and age. Overall, SSiNGLe provides access to unexplored realm of cellular biology, not obtainable with current approaches.
Spatio-temporal impact of self-financed rotavirus vaccination on rotavirus and acute gastroenteritis hospitalisations in the valencia region, spain.
Authors: López-Lacort Mónica , Orrico-Sánchez Alejandro , Martínez-Beneito Miguel Ángel , Muñoz-Quiles Cintia , Díez-Domingo Javier 
Published: August 2020

Abstract
Background

Several studies have shown a substantial impact of Rotavirus (RV) vaccination on the burden of RV and all-cause acute gastroenteritis (AGE). However, the results of most impact studies could be confused by a dynamic and complex space-time process. Therefore, there is a need to analyse the impact of RV vaccination on RV and AGE hospitalisations in a space-time framework to detect geographical-time patterns while avoiding the potential confusion caused by population inequalities in the impact estimations.

Methods

A retrospective population-based study using real-world data from the Valencia Region was performed among children aged less than 3 years old in the period 2005-2016. A Bayesian spatio-temporal model was constructed to analyse RV and AGE hospitalisations and to estimate the vaccination impact measured in averted hospitalisations.

Results

We found important spatio-temporal patterns in RV and AGE hospitalisations, RV vaccination coverage and in their associated adverted hospitalisations. Overall, ~1866 hospital admissions for RV were averted by RV vaccination during 2007–2016. Despite the low-medium vaccine coverage (~50%) in 2015-2016, relevant 36% and 20% reductions were estimated in RV and AGE hospitalisations respectively.

Conclusions

The introduction of the RV vaccines has substantially reduced the number of RV hospitalisations, averting ~1866 admissions during 2007-2016 which were space and time dependent. This study improves the methodologies commonly used to estimate the RV vaccine impact and their interpretation.