bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effectiveness of Science Multimedia Interactive Based on Aurora 3D Presentation on Student Learning Outcomes
Authors: Suhardi Andi , Rosalina Sevie Safitri , Sutrisno Nina 
Published: December 2020

This research aims to study significant differences between learning by using interactive multimedia based on Aurora 3D Presentation with conventional methods on student learning outcomes in Environmental pollution material. This type of research is a quantitative study using a research design consisting of a post-test control group. The sample in this study was grade VII students of SMP Negeri 1 Jember. There are two groups namely the experimental group taken from class VII C and the control group taken from class VII A which is determined by a purposive sampling technique. The instrument to collect data using a post-test. Analysis of the data used is a t-test consisting of independent sample t-tests. Based on the t-test on student learning outcomes through the post-test, the t-count value was 2.015 and the t-table value was 1.669. Because t-count is greater than t-table, The use of Aurora 3D Presentation in learning is effective for the subject environmental pollution at the Seventh Grade of junior high school students.
Strategi Peningkatan Produktivitas Kopi serta Adaptasi terhadap Variabilitas dan Perubahan Iklim melalui Kalender Budidaya
Authors: Sarvina Yeli , June Tania , Surmaini Elza , Nurmalina Rita , Hadi Sutjahjo Surjono 
Published: December 2020

<p><strong>Abstrak</strong>. Rendahnya produktivitas kopi merupakan salah satu permasalahan utama dalam sistem produksi kopi Indonesia. Hal ini diantaranya disebabkan tidak adanya perawatan kopi yang optimal dengan memperhatikan fase fenologi kopi, serta dampak variabilitas dan perubahan iklim. Berbagai teknologi adaptasi kopi sudah banyak dihasilkan namun langkah adaptasi dengan memanfaatkan prakiraan iklim dalam bentuk penyesuian kegiatan budidaya dengan fase fenologi atau disebut sebagai kalender budidaya belum dikembangkan. Tulisan ini memaparkan tentang dampak variabilitas dan perubahan iklim pada tanaman kopi, teknologi adaptasi kopi yang sudah tersedia, perlunya pengembangan kalender budidaya kopi sebagai bentuk strategi adaptasi dan peningkatan produktivitas serta potensi dan tantangan pengembangan kalender budidaya kopi di Indonesia. Hasil review ini menunjukkan kalender budidaya kopi berpotensi dikembangkan sebagai strategi peningkatan produktivitas serta adaptasi terhadap variabilitas dan perubahan iklim.</p><p> </p><p><strong>Abstract</strong>. Low productivity is one of the main challenges in Indonesia's coffee production system .It is low due to cultivation management; most of the coffee farmer does not manage their plantation base on the coffee phenology phase. Moreover climate variability and change also have important effect on coffee productivity. Various technologies on adaptation and measurement to climate change and variability have been identified. Unfortunately, the technology which use climate forecast through adjusting cultivation activity and coffee phenology called as cultivation calendar do not exist yet. This paper provides an overview on the impact of climate variability and change to coffee production, the existing adaptation strategy, and the importance of cultivation calendar as a strategy for adapting and increasing productivity, and the potential and challenges to develop cultivation calendar in Indonesia. This review reveals that coffee cultivation calendar is a potential strategy for increaseing productivity and adapting climate change and variability.</p>
Salinisasi Lahan dan Permasalahannya di Indonesia
Authors: Karolinoerita Vicca , Annisa Wahida 
Published: December 2020

<p><strong>Abstrak. </strong>Salinisasi tanah merupakan proses peningkatan kadar garam mudah larut di dalam tanah sehingga terbentuk lahan salin. Salinitas adalah salah satu cekaman abiotik yang mengakibatkan berkurangnya hasil dan produktivitas tanaman pertanian. Setiap tahun luas lahan sawah yang ditinggalkan petani akibat mengalami salinisasi terus meningkat. Di Indonesia salinitas umumnya terjadi di lahan pertanian dekat pantai, disebabkan karena kenaikan permukaan laut akibat perubahan iklim. Diperkirakan lahan dekat pantai yang rentan mengalami salinitas seluas 12,020 juta ha atau 6,20% dari total daratan Indonesia. Problem salinitas pada pertanian beririgasi sering terkait dengan muka air tanah. Peningkatan kapilaritas dari muka air tanah dangkal akan membawa kembali garam-garam masuk ke daerah perakaran dan menjadi suatu sumber garam berkelanjutan. sedangkan salinitas di lahan rawa pasang surut dipengaruhi oleh pergerakan pasang surut air laut dengan tingkat salinitas yang bervariasi. Tanaman mempunyai kisaran toleransi tertentu terhadap perubahan bahkan cekaman lingkungan untuk selanjutnya dapat beradaptasi, termasuk pada cekaman salinitas. Kondisi biofisik dan kimia lahan sawah terdampak yang tidak menguntungkan tanaman tersebut memerlukan upaya pengelolaan lahan dan sistem budidaya tanaman secara tepat agar dicapai tingkat produksi yang optimal.</p><p> </p><p><em><strong>Abstract</strong>. Soil salinization is the process of increasing the soluble salt content in the soil to form a saline soil. Salinity is an abiotic stress that results in reducing yield and productivity of agricultural crops. The area of paddy fields left by farmers as a result of experiencing salinization continues to increase every tear. In Indonesia, salinity generally occurs in agricultural land near the coast, caused by sea level rise due to climate change. It is estimated that land near the coast that is prone to experiencing salinity is 12.020 million ha or 6.20% of the total land area of Indonesia. The problem of salinity in irrigated agriculture is often related to the water table. The increase in capillarity from shallow groundwater levels will bring back salts into the root zone and become a continuous salt source. Salinity in tidal swamps is influenced by the tidal movement of sea water with varying salinity levels. Plants have a certain tolerance range to the changes and even environmental stress so that they can then adapt, including to salinity stress. The biophysical and chemical conditions of the affected paddy fields that are not beneficial to the plant, requires proper land management and crop cultivation systems in order to achieve optimal production levels.</em></p>
A Hypothesis about the Predominantly Gravitational Nature of Redshift in the Electromagnetic Spectra of Space Objects
Authors: Tiguntsev Stepan 
Published: December 2020

Abstract
The study theoretically substantiates the relationship between the redshift in the electromagnetic spectrum of space objects and their gravity and demonstrates it with computational experiments. Redshift, in this case, is a consequence of a decrease in the speed of the photons emitted from the surface of objects, which is caused by the gravity of these objects. The decline in the speed of photons due to the gravity of space gravitating object (GO) is defined as ΔC = C-C ', where: C' is the photon speed changed by the time the receiver records it. Then, at a change in the photon speed between a stationary source and a receiver, the redshift factor is determined as Z = (C-C ')/C'. Computational experiments determined the gravitational redshift of the Earth, the Sun, a neutron star, and a quasar. Graph of the relationship between the redshift and the ratio of sizes to the mass of any space GOs was obtained. The findings indicate that the distance to space objects does not depend on the redshift of these objects.
Levosimendan prevents tau pathology by inhibiting disulfide-linked tau oligomerization posing as a promising anti-tau therapeutics
Authors: Kim Yun Kyung , Lim Sungsu , Shin Seulgi , Lee Ha Eun , Song Ji Yeon , Sung Yoonsik , Lee Gwan-Ho , Yu Byung-Yong , Aziz Hira , Lukianenko Nataliia , Kim Kyu Hyeon , Jeong Hyeanjeong , Lim Sang Min , Lee Jun-Seok , Pae Ae Nim 
Published: December 2020

Abstract
Tau oligomers play critical roles in tau pathology, responsible for neuronal cell death and transmitting the disease in the brain. Accordingly, preventing tau oligomerization becomes an important therapeutic strategy to treat tauopathies including Alzheimer’s disease, however progress has been slow due to difficulties of detecting tau oligomers in cellular context. Toward tau-targeted drug discovery, our group have developed a tau-BiFC platform to monitor and quantify tau oligomerization. By using the tau-BiFC platform, we screened 1,018 compounds in FDA-approved & Passed Phase I drug library, and identified levosimendan as a potent anti-tau agent inhibiting tau oligomerization. 14C-isotope labeling of levosimendan identified that levosimendan covalently bound to tau cysteines, directly inhibiting disulfide-linked tau oligomerization. In addition, levosimendan was able to disassemble tau oligomers into monomers, and rescuing neurons from aggregation states. In comparison, the well-known anti-tau agents, methylene blue (MB) and LMTM, failed to protect neurons from tau-mediated toxicity, generating high-molecular weight tau oligomers. The administration of levosimendan also suppressed tau pathology in the brain, preventing cognitive declines in TauP301L-BiFC transgenic mice. Although careful validation is required, here we present the potential of levosimendan as a disease modifying therapy for tauopathies targeting tau oligomerization.
Antibacterial and Antibiofilm Effects Extracts From Elaeagnus Angustifolia,satureja Montana, Quercus Brantii, Tragopogon Dubius, Sonchus Asper, on the P.aeruginosa and S.aureus
Authors: Hosseini Razieh Sadat , khaledi Mansoor , Gholipour Abolfazl 
Published: December 2020

Abstract
Background: Due to the increase in microbial resistance worldwide and the adverse effects of chemical drugs, the study of antimicrobial compounds in plant extracts as a new source of medicine can be effective in reducing or solving this problem. The purpose of this study antibacterial and antibiofilm effects extracts from Elaeagnus angustifolia,satureja montana, Quercus brantii,Tragopogon dubius,Sonchus asper, on the P.aeruginosa and S.aureus Methods: In this cross-sectional descriptive-analytical study, the study population is plants collected in Isfahan and Shahrekord and Pseudomonas and S.aureus bacteria isolated from clinical samples and standard strains. The sampling method was improbably simple and 120g was collected from each of the 9 plants and extracted by massage method. For the qualitative evaluation of antimicrobial properties, you used the agar well diffusion method and for quantitative evaluation of antimicrobial properties, you used the plate microtiter method. To evaluate the anti-biofilm properties, plate microtiter method, and staining by violet crystal were used. Results: Based on the findings of this study and the study of MBC and MIC of the mentioned plant extracts, it can be said that the best antibacterial effect on all studied strains belongs to the plant extracts of Quercus brantii, Elaeagnus angustifolia, satureja montana, Tragopogon dubius, and Sonchus asper, respectively. Among them, Quercus brantii extract has the best effect on all 4 strains. Also, in the study of anti-biofilm properties, it was observed that the Quercus brantii, satureja montana, and Elaeagnus angustifolia plant extracts had an anti-biofilm effect. Among them, respectively, the most belonging to the Quercus brantii, and the two extracts of Tragopogon dubius, and Sonchus asper do not have good anti-biofilm properties.Conclusions: According to the results of this study on the antimicrobial and antifouling properties of these extracts, it is possible to use this plant in the future with more studies and more work on these plants.
Genome-Wide Analysis of PR-1 Genes From Piper Nigrum Reveals Critical Role in Defense Response During Phytophthora Capsici Infection
Authors: Kattupalli Divya , Sriniva Asha , V Soniya E 
Published: December 2020

Abstract
Background: Black pepper is a prominent spice which is an indispensable ingredient in culinary and traditional medicine. Phytophthora capsici, the causative agent of foot rot disease causes drastic constraint in black pepper cultivation and productivity. To counterattack various biotic and abiotic stresses plants employ a broad array of mechanisms one such includes the accumulation of pathogenesis-related (PR) proteins. Several studies have reported the role of PR-1 proteins in triggering the plant defenses during plant-oomycete interaction.Results: Through the genome-wide survey, eleven PR-1 genes that belongs to a CAP superfamily protein with Caveolin-Binding Motif (CBM) and CAP-derived peptide (CAPE) were identified from P. nigrum. Despite the critical functional domains, PnPR1 homologs differ in their signal peptide motifs, and core amino acid sequence composition in the functional protein domains. The GO, biological function analysis reveals their role in defense responses and response to biotic stimulus whereas the KEGG functional annotation predicted their function in the plant-pathogen interactions. Furthermore, transcriptome-assisted FPKM analysis revealed PnPR-1 genes mapped to P. nigrum - P. capsici interaction pathway. The differentially expressed pathogen-responsive PR-1 gene was validated through qRT-PCR. Subsequent analysis revealed the structural details, phylogenetic relationships, conserved sequence motifs and critical cis-regulatory elements of PnPR-1 genes.Conclusion: This is the first genome-wide study that identified the role of PR-1 genes during P. nigrum - P. capsici interactions. The detailed in silico experimental analysis revealed the vital role of PnPR-1 genes in regulating the first layer of defense towards P. capsici infection in Panniyur-1 plants.
The epidemiology, risk factors, mortality rate, diagnosis, etiologies and treatment of neonatal respiratory distress: a scoping review
Authors: Tochie Joel Noutakdie , Sibetcheu Aurelie T. , Danwang Celestin , Mbonda Aime Noula , Kamla Igor , Ayissi Gregory , Nkeck Jan René , Ngwanou Dany Hermann , Temgoua Mazou Ngou 
Published: December 2020

Abstract
Background: Quite a tricky day-to-day clinical condition which may present as the first alarming sign of a life-threatening pathology, neonatal respiratory distress (NRD) remains an emergency until its etiology is diagnosed and appropriate treated delivered to the neonate. While the prevalence, risk factors, etiologies, diagnosis and management of this potentially fatal neonatal condition has not been examined extensively, the objective of this scoping review is to synthesise contemporary studies on the prevalence, risk factors, etiologies, diagnosis and management of NRD. Methods: We searched MEDLINE and Google Scholar up to November 13, 2020 for observational and experimental studies and systematic reviews addressing NRD without language restriction. Eight investigators working in four pairs independently selected and extracted relevant data. The methodological quality of all included studies was assessed.Results: We included 81 studies eligible with a total of 511,158 neonates from 21 countries across the world. The risk of bias was low in 61 (75%), moderate in 14 (17%), and high in six (8%) studies. The prevalence of NRD ranged from 0.21 to 84.8% and the highest prevalence rates were observed in Saudi Arabia (78.5%) and Iraq (84.8%). Its highest reported case fatality rates were in Sudan (36%) and India (47.1%). Predisposing factors included prematurity, male gender, low and high birth weights, low socio-economic status, smoking, infectious anamneses, diabetes mellitus, antepartum haemorrhage, cesarean delivery, fetal distress, anesthetic drugs and meconium stained amniotic fluid. Attending four or more antenatal care visits conveyed protection against NRD. Its diagnosis was mainly clinical using the Silverman-Anderson score. Its leading etiology was neonatal infection followed by transient tachypnoea of the newborn and hyaline membrane disease. With regards to its management, it is widely recommended to start with resuscitation followed by specific management of the etiology of NRD by medical or surgical measures or both. Conclusion: The prevalence and mortality rates of NRD are alarming, particularly in low- and middle-income countries. Most of its risk factors are preventable. Neonatal infections is the leading cause of NRD. Overall, we have presented an updated overview of NRD which should serve to ameliorate its healthcare.
One Thing at a Time… Timeliness of Rehabilitation for Sexual Problems in Men With Prostate Cancer
Authors: Dieperink Karin B. , Mortensen Mike Allan , Zwisler Ann-Dorthe Olsen , Herrstedt Jørn , Hansen Dorte Gilså , Lund Lars 
Published: December 2020

Abstract
ObjectiveThe randomised clinical trial ProCaRe (Prostate Cancer Rehabilitation) aimed to test the effect of sexual pre-habilitation in prostate cancer patients treated with radiotherapy concomitant with androgen deprivation therapy.We planned recruitment of 92 participants. The complex intervention designed with previously treated patients and partners included sexual counselling, penile rehabilitation and supervised exercise in groups. The primary outcome was sexual functioning measured by the International Index of Erectile Function Score (IIEF-5). The secondary outcomes included a reduction in irritative urinary problems and improvement in quality of life.ResultsWe identified eight eligible patients among nine screened between January 22th and June 1st, 2018. Among these patients, three accepted study enrollment but one withdrew because of a lack of energy. The study was closed because of slow recruitment, i.e. a low number of eligible patients and low participation rate (38%) according to the timeframe and intervention planned. The study had a strong design but was not sufficiently pilot-tested because the study site had too few eligible patients. Furthermore, at this early time of the disease trajectory, sexual rehabilitation was not perceived relevant to the patients or prioritised. Future studies should be co-designed with patients more representative for the target group.
Transcriptomic Profiling of Fe-Responsive lncRNAs and Their Regulation in Rice
Authors: Wang Shoudong , Sun Shuo , Guo Runze , Liao Wenying , Shou Huixia 
Published: December 2020

Abstract
Background Iron (Fe) plays a vital role in various cellular processes in plants, including biosynthesis of chlorophyll, photosynthesis and respiration. Fe deficiency directly affects crop growth and development, ultimately resulting in reduced crop yield and quality. Long non-coding RNAs (lncRNAs) have recently been demonstrated to play critical regulatory roles in a multitude of pathways across numerous species. However, systematic screening of lncRNAs responding to Fe deficiency in plants has not been reported. Results In this work, lncRNAs responsive to Fe deficiency were identified across the rice genome by strand-specific RNA sequencing. In total, 6,477 lncRNAs were identified. In Fe-deficient conditions, 47 lncRNAs were up-regulated and 33 lncRNAs were down-regulated in shoots, while 89 lncRNAs were up-regulated and 32 lncRNAs were down-regulated in roots, compared to normal conditions. Two lncRNAs (XLOC_010112 and XLOC_053944) were identified as potential miRNA precursors and another two (XLOC_012715 and XLOC_054182) as miRNA target mimics that may participate in Fe regulation. A number of differentially expressed lncRNAs (DE-lncRNAs) are likely to modulate the expression of Fe-related genes via a cis- or trans-regulation mode, including 3 DE-lncRNAs (XLOC_034336, XLOC_037283 and XLOC_043545) located nearby OsbHLH156 and OsHRZ2 genomic regions. Seventy-six DE-lncRNAs were found to be regulated by bHLH156 at the transcriptional level. Conclusions This study provides a first profile of lncRNA expression as well as identifies the lncRNAs likely to play important roles in the regulation of Fe homeostasis. This identification and characterization form an important basis for understanding Fe regulatory networks in rice.
Patterns of Physical Activity and Their Relationship With Depression Among Community-Dwelling Older Adults in Shanghai, China: A Latent Class Approach
Authors: Liang Yan , Li Xinghui , Yang Tingting , Li Mengying , Ruan Ye , Yang Yinghua , Huang Yanyan , Jiang Yihua , Wang Ying 
Published: December 2020

Abstract
Background: Few studies have explored patterns of physical activity (PA) and examined their relationship with depression among community-dwelling older adults. An understanding of PA patterns in this population may have implications for the development of community interventions, both to support beneficial patterns of PA and to target specific latent classes of community-dwelling older adults.Methods: We conducted a cross-sectional survey study in the Minhang district, Shanghai, China, in August 2019, and used a self-administered questionnaire to collect data through home visits. The total sample included 2,525 older adults. This study used the Physical Activity Scale for the Elderly (PASE) to assess the quantity of PA in older adults. Depression was evaluated with the Geriatric Depression Scale (GDS). Latent class analysis (LCA) was used to identify subpopulations by shared item response patterns. Logistic regressions were performed to estimate the relationship between PASE score, patterns of PA, and depression.Results: Four latent classes were identified: “domestic types,” “athletic types,” “gardening/caring types,” and “walkers.” PASE scores and latent class predicted depression independently. Older adults who were the most active (PASE quartile: 75–100%) and the athletic types had the strongest significant association with depression (relative risk = 0.21, 95% CI: 0.06–0.68), followed by those who were the most active (PASE quartile: 75–100%) and the walkers (relative risk = 0.28, 95% CI: 0.14–0.57) when compared with older adults with the least activity (PASE quartile: 0–25%) and domestic types. Older adults who were the most active (PASE quartile: 75–100%) and the gardening/caring types were most likely to be depressed (relative risk = 1.66, 95% CI: 1.03–2.69).Conclusion: This study suggests an overall protective effect of physical activity on depression among community-dwelling older adults. Population-level intervention should combine being athletic with other patterns of physical activity. To develop individual-level tailored interventions, more attention should be paid to older adults who are highly engaged in caring for others.