bluuebunny/crossref_metadata_2025_split huggingface dataset:
Appropriate Smart Factory for SMEs: Concept, Application and Perspective
Authors: Jung Woo-Kyun , Kim Dong-Ryul , Lee Hyunsu , Lee Tae-Hun , Yang Insoon , Youn Byeng D. , Zontar Daniel , Brockmann Matthias , Brecher Christian , Ahn Sung-Hoon 
Published: December 2020

AbstractIn the manufacturing industry, the smart factory is considered the final stage of the Fourth Industrial Revolution. Manufacturing companies are pursuing breakthroughs by introducing various advanced technologies to ensure their competitiveness. However, it is difficult for small and medium-sized enterprises (SMEs) to adopt smart-factory technologies, owing to financial and technical burdens. This paper proposes a smart factory that can be applied technically and strategically to the introduction of a smart factory for SMEs. The concept of an ‘appropriate smart factory’ involves applying appropriate measures in terms of cost and scale with consideration of the situations faced by SMEs. The goal is to build a smart factory that has necessary functions (Essential) but can be easily operated (Simple) at a low cost (Affordable) and has compatibility (Interoperable). This paper presents technical application measures such as appropriate smart sensors, appropriate IoT (Internet of Things), and small data processing, along with the definition of an appropriate smart factory. In addition, a case study was examined where the quality inspection equipment for garment manufacturing SMEs was developed by applying the appropriate smart factory concept.
How will climate change alter the dynamics of airborne pollen and pollen load of allergenic plants?
Authors: Schinko Herwig A. E. , Lamprecht Bernd , Schmidt Roland 
Published: December 2020

Summary
Background
Globally, climate change is being observed. Pollen allergies have been increasing since the middle of the last century. Outdoors, sensitization against pollen allergens is responsible for the highest prevalence of allergies of eyes and airways. Hence, the following two questions arose: (1) How does climate change become manifest locally–regionally, and do temperatures and precipitation have to be considered exceptional in 2018? (2) How do changing meteorological conditions impact on pollination and pollen load?

Methods
Pollen data of the main allergenic plants—collected at the pollen monitoring station Linz, Upper Austria—were analysed; 2018 was compared to the years 1993–2017. By means of statistical methods, the impact of meteorological parameters on pollen seasons and pollen load were examined.

Results
Climate change was confirmed for the region. The regional climate has shifted from moderate to warmer and drier (semi-arid) conditions. Preseasonal cumulated meteorological parameters determined flowering and pollen seasons (PS). Start and duration of the pollination of hazel, alder, birch, and grass followed other rules than the seasonal pollen production, termed seasonal pollen integral (SPIn). By its hybrid character, the model-year 2018 offered the unique chance to generate and explain different scenarios of pollen emission and transmission. For the start of flowering of hazel (Corylus), alder (Alnus) and birch (Betula), the coincidence of cumulated mean daily warmth (MDWcumul) and a distinct threshold for the highest temperature of a day (HTD) is necessary and species-specific. In 2018, the earliest begin of the pollen season (PSB) was observed. Frost delayed the PSB. Preseasonal frost as well as cool temperatures caused SPIn of alder and birch to rise, whereas SPIn of hazel were increased by warmer temperatures. Warm weather prolonged pollen seasons of early flowering plants. Heat combined with drought shortened PS of birch in 2018. Cumulated relative humidity (RHcumul) correlated highly significant with the PSB of grasses. Warm and dry conditions in 2018 caused the earliest PSB of grass since 1993. Over the years, SPI and major pollen peaks of grasses have decreased, primarily due to dryness.

Conclusion
The assumption that climate warming in Linz over 26 years should have increased pollen concentrations of allergenic plants was not confirmed. On the contrary, trend analyses showed that the pollen load has decreased. Hence, the increase in sensitization to pollen allergens and of the prevalence of pollen allergies ask for other explanations.
»letzte Politur«?
Authors: Christ Tobias 
Published: December 2020

ZusammenfassungHölderlin war wenig erfolgreich bei dem Versuch, sich mit seiner Lyrik gegen die zeitgenössischen Geschmacksanforderungen zu behaupten. Davon zeugt die Publikationsgeschichte seiner Elegie »Der Wanderer«. Erstmals 1797 bei Schiller für Die Horen eingereicht, erfuhr der Text in der Folge mehrfache Nachbearbeitungen: zunächst durch Hölderlin selbst, dann durch Schiller und schließlich durch Matthisson, der für den Abdruck in seiner Lyrischen Anthologie (1806) wiederum tiefgreifende Anpassungen vornahm. Die Überarbeitungen beider erfolgreichen Lyriker verbannen den ursprünglichen Reflexionsgehalt und glätten die formale und bildliche Dynamik zugunsten von Anschaulichkeit und Gefälligkeit. Dies gibt Aufschluss über die zeitgenössischen Geschmackskonventionen und damit über die Erfolgsvoraussetzungen für Lyrik um 1800, von denen sich Hölderlin mit der Herausbildung seines Individualstils zunehmend entfernte.
Surgical Management of Idiopathic Partial Thrombosis of the Corpus Cavernosum
Authors: Singh Danish , Larson Troy , Campbell Kevin , Dennis Michael , Yeung Lawrence 
Published: December 2020

Abstract
A 36-year-old African American man presented to the emergency department with 2 days of left-sided perineal pain after sexual activity. He was found to have induration in the left perineum overlying the proximal left corporal body. Clinical picture was suspicious for traumatic corporal rupture; however, advanced imaging showed a proximal segmental thrombosis of the left corpus cavernosum. The patient underwent perineal exploration with evacuation of an intracorporal penile hematoma. In spite of disrupting a fibrous membrane in the proximal corpora and drainage of the corpora, we observed repeat tumescence during the procedure because of an observed arterial high-flow state in the corpora cavernosum. This was resolved with administration of phenylephrine into the cavernosum. The patient had return of normal erectile function 2 days after the procedure with resolution of pain at the site.
Variability of Pornographic Content Consumed and Longest Session of Pornography Use Associated With Treatment Seeking and Problematic Sexual Behavior Symptoms
Authors: Lewczuk Karol , Lesniak Joanna , Lew-Starowicz Michal , Gola Mateusz 
Published: December 2020

Abstract

Introduction
Most of the previous studies on problematic pornography use and related behavior have focused on such descriptors of pornography use habits as frequency or time devoted to pornography use.

Aim
We argue that this constitutes a narrow view and indicators that characterize other aspects of explicit content consumption, namely (i) longest session of pornography viewing (which may be related to binge behavior), as well as (ii) variability of consumed pornographic content, can also be useful indicators.

Methods
An online study based on a sample of 132 heterosexual men seeking treatment for problematic pornography use, referred by therapists after their initial visit and 437 non-treatment seekers in the control group.

Main Outcome Measures
The main outcomes of this study are reported longest, non-stop session of viewing pornography, variability in consumed pornographic content (including paraphilic and violent pornography), actual treatment seeking for problematic pornography use and severity of symptoms, and average weekly time devoted to pornography use.

Results
Our analysis showed that longest session of viewing pornographic content as well as the variety of consumed pornography influenced the decision to seek treatment and the severity of symptoms even when the sheer amount of time devoted to pornography use was controlled.

Conclusion
This is one of the few studies examining the role of engagement in prolonged sessions of pornography use and the variability of consumed pornographic content in the clinical context of problematic sexual behavior. The study's main limitations are its relatively narrow method of operationalization of variability of pornographic content and longest session of pornography viewing, as well as its cross-sectional, online, and anonymous character. As the described factors have an important influence on treatment seeking and the severity of experienced symptoms, they should be considered in the process of assessing compulsive sexual behavior disorder and related symptoms.
Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group
Authors: Leerssen Jeanne , Blanken Tessa F. , Pozzi Elena , Jahanshad Neda , Aftanas Lyubomir , Andreassen Ole A. , Baune Bernhard T. , Brack Ivan , Carballedo Angela , Ching Christopher R. K. , Dannlowski Udo , Dohm Katharina , Enneking Verena , Filimonova Elena , Fingas Stella M. , Frodl Thomas , Godlewska Beata R. , Goltermann Janik , Gotlib Ian H. , Grotegerd Dominik , Gruber Oliver , Harris Mathew A. , Hatton Sean N. , Hawkins Emma , Hickie Ian B. , Jaworska Natalia , Kircher Tilo , Krug Axel , Lagopoulos Jim , Lemke Hannah , Li Meng , MacMaster Frank P. , McIntosh Andrew M. , McLellan Quinn , Meinert Susanne , Mwangi Benson , Nenadić Igor , Osipov Evgeny , Portella Maria J. , Redlich Ronny , Repple Jonathan , Sacchet Matthew D. , Sämann Philipp G. , Simulionyte Egle , Soares Jair C. , Walter Martin , Watanabe Norio , Whalley Heather C. , Yüksel Dilara , Veltman Dick J. , Thompson Paul M. , Schmaal Lianne , Van Someren Eus J. W. 
Published: December 2020

AbstractIt has been difficult to find robust brain structural correlates of the overall severity of major depressive disorder (MDD). We hypothesized that specific symptoms may better reveal correlates and investigated this for the severity of insomnia, both a key symptom and a modifiable major risk factor of MDD. Cortical thickness, surface area and subcortical volumes were assessed from T1-weighted brain magnetic resonance imaging (MRI) scans of 1053 MDD patients (age range 13-79 years) from 15 cohorts within the ENIGMA MDD Working Group. Insomnia severity was measured by summing the insomnia items of the Hamilton Depression Rating Scale (HDRS). Symptom specificity was evaluated with correlates of overall depression severity. Disease specificity was evaluated in two independent samples comprising 2108 healthy controls, and in 260 clinical controls with bipolar disorder. Results showed that MDD patients with more severe insomnia had a smaller cortical surface area, mostly driven by the right insula, left inferior frontal gyrus pars triangularis, left frontal pole, right superior parietal cortex, right medial orbitofrontal cortex, and right supramarginal gyrus. Associations were specific for insomnia severity, and were not found for overall depression severity. Associations were also specific to MDD; healthy controls and clinical controls showed differential insomnia severity association profiles. The findings indicate that MDD patients with more severe insomnia show smaller surfaces in several frontoparietal cortical areas. While explained variance remains small, symptom-specific associations could bring us closer to clues on underlying biological phenomena of MDD.
Chronic traumatic encephalopathy—a blueprint for the bridge between neurological and psychiatric disorders
Authors: Albayram Onder , Albayram Sait , Mannix Rebekkah 
Published: December 2020

AbstractChronic traumatic encephalopathy (CTE) is a perplexing condition characterized by a broad and diverse range of neuropathology and psychopathology. While there are no agreed upon or validated clinical criteria for CTE, case series of CTE have described a wide range of neuropsychiatric symptoms that have been attributed to repetitive traumatic brain injuries (rTBI). However, the direct links between the psychopathology of psychiatric and neurological conditions from rTBI to CTE remains poorly understood. Prior studies suggest that repetitive cerebral injuries are associated with damage to neural circuitry involved in emotional and memory processes, but these studies do not offer longitudinal assessments that prove causation. More recent studies on novel targets, such as transmission of misfolded proteins, as well as newly advanced non-invasive imaging techniques may offer more direct evidence of the pathogenesis of CTE by tracing the progression of pathology and display of related behavioral impairments. Understanding this interface in the context of rTBI can play an important role in future approaches to the definition, assessment, prevention, and treatment of CTE and mental illnesses.
Amyloid-beta uptake by blood monocytes is reduced with ageing and Alzheimer’s disease
Authors: Chen Si-Han , Tian Ding-Yuan , Shen Ying-Ying , Cheng Yuan , Fan Dong-Yu , Sun Hao-Lun , He Chen-Yang , Sun Pu-Yang , Bu Xian-Le , Zeng Fan , Liu Juan , Deng Juan , Xu Zhi-Qiang , Chen Yang , Wang Yan-Jiang 
Published: December 2020

AbstractDeficits in the clearance of amyloid β-protein (Aβ) play a pivotal role in the pathogenesis of sporadic Alzheimer’s disease (AD). The roles of blood monocytes in the development of AD remain unclear. In this study, we sought to investigate the alterations in the Aβ phagocytosis function of peripheral monocytes during ageing and in AD patients. A total of 104 cognitively normal participants aged 22–89 years, 24 AD patients, 25 age- and sex-matched cognitively normal (CN) subjects, 15 Parkinson’s disease patients (PD), and 15 age- and sex-matched CN subjects were recruited. The Aβ uptake by blood monocytes was measured and its alteration during ageing and in AD patients were investigated. Aβ1-42uptake by monocytes decreased during ageing and further decreased in AD but not in PD patients. Aβ1-42uptake by monocytes was associated with Aβ1-42levels in the blood. Among the Aβ uptake-related receptors and enzymes, the expression of Toll-like receptor 2 (TLR2) was reduced in monocytes from AD patients. Our findings suggest that monocytes regulate the blood levels of Aβ and might be involved in the development of AD. The recovery of the Aβ uptake function by blood monocytes represents a potential therapeutic strategy for AD.
Direct comparison of ARPES, STM, and quantum oscillation data for band structure determination in Sr2RhO4
Authors: Battisti I. , Tromp W. O. , Riccò S. , Perry R. S. , Mackenzie A. P. , Tamai A. , Baumberger F. , Allan M. P. 
Published: December 2020

AbstractDiscrepancies in the low-energy quasiparticle dispersion extracted from angle-resolved photoemission, scanning tunneling spectroscopy, and quantum oscillation data are common and have long haunted the field of quantum matter physics. Here, we directly test the consistency of results from these three techniques by comparing data from the correlated metal Sr2RhO4. Using established schemes for the interpretation of the experimental data, we find good agreement for the Fermi surface topography and carrier effective masses. Hence, the apparent absence of such an agreement in other quantum materials, including the cuprates, suggests that the electronic states in these materials are of different, non-Fermi liquid-like nature. Finally, we discuss the potential and challenges in extracting carrier lifetimes from photoemission and quasiparticle interference data.
Bayesian decision-making under stress-preserved weighting of prior and likelihood information
Authors: Trapp Sabrina , Vilares Iris 
Published: December 2020

AbstractA rich body of empirical work has addressed the question of how stress changes the way we memorize, learn, and make high-level decisions in complex scenarios. There is evidence that stress also changes the way we perceive the world, indicating influences on decision-making at lower levels. Surprisingly, as of yet, little research has been conducted in this domain. A few studies suggest that under stress, humans tend to eschew existing knowledge, and instead focus on novel input or information from bottom-up. Decision-making in the perceptual domain has been modeled with Bayesian frameworks. Here, existing knowledge about structures and statistics of our environment is referred to as prior, whereas sensory data are termed likelihood. In this study, we directly assessed whether stress, as induced by the socially evaluated cold pressure task (SECPT), would modulate low-level decisions, specifically the weight given to sensory information, and how people reacted to changes in prior and sensory uncertainty. We found that while the stress-inducing procedure successfully elicited subjective stress ratings as
well as stress relevant physiological paramters, it did not change participants’ average reliance on sensory information. Furthermore, it did not affect participants’ sensitivity to changes in prior and sensory uncertainty, with both groups able to detect it and modulate their behavior accordingly, in a way predicted by Bayesian statistics. Our results suggest that, contrary to our predictions, stress may not directly affect lower-level sensory-motor decisions. We discuss the findings in context of time scales of the stress reaction, linked to different neural and functional consequences.
Co-expression network analysis of protein phosphatase 2A (PP2A) genes with stress-responsive genes in Arabidopsis thaliana reveals 13 key regulators
Authors: Khan Zaiba Hasan , Agarwal Swati , Rai Atul , Memaya Mounil Binal , Mehrotra Sandhya , Mehrotra Rajesh 
Published: December 2020

AbstractAbiotic and biotic stresses adversely affect plant growth and development and eventually result in less yield and threaten food security worldwide. In plants, several studies have been carried out to understand molecular responses to abiotic and biotic stresses. However, the complete circuitry of stress-responsive genes that plants utilise in response to those environmental stresses are still unknown. The protein phosphatase 2A (PP2A) gene has been known to have a crucial role in abiotic and biotic stresses; but how it regulates the stress response in plants is still not known completely. In this study, we constructed gene co-expression networks of PP2A genes with stress-responsive gene datasets from cold, drought, heat, osmotic, genotoxic, salt, and wounding stresses to unveil their relationships with the PP2A under different conditions of stress. The graph analysis identified 13 hub genes and several influential genes based on closeness centrality score (CCS). Our findings also revealed the count of unique genes present in different settings of stresses and subunits. We also formed clusters of influential genes based on the stress, CCS, and co-expression value. Analysis of cis-regulatory elements (CREs), recurring in promoters of these genes was also performed. Our study has led to the identification of 16 conserved CREs.
Colour-sensitive conjugated polymer inkjet-printed pixelated artificial retina model studied via a bio-hybrid photovoltaic device
Authors: Ciocca Manuela , Giannakou Pavlos , Mariani Paolo , Cinà Lucio , Di Carlo Aldo , Tas Mehmet O. , Asari Hiroki , Marcozzi Serena , Camaioni Antonella , Shkunov Maxim , Brown Thomas M. 
Published: December 2020

AbstractIn recent years, organic electronic materials have been shown to be a promising tool, even transplanted in vivo, for transducing light stimuli to non-functioning retinas. Here we developed a bio-hybrid optoelectronic device consisting of patterned organic polymer semiconductors interfaced with an electrolyte solution in a closed sandwich architecture in order to study the photo-response of photosensitive semiconducting layers or patterns in an environment imitating biological extracellular fluids. We demonstrate an artificial retina model composed of on an array of 42,100 pixels made of three different conjugated polymers via inkjet printing with 110 pixels/mm2packing density. Photo-sensing through three-colour pixelation allows to resolve incoming light spectrally and spatially. The compact colour sensitive optoelectronic device represents an easy-to-handle photosensitive platform for the study of the photo response of artificial retina systems.
Synthetic Host Defense Peptides Inhibit Venezuelan Equine Encephalitis Virus Replication and the Associated Inflammatory Response
Authors: Ahmed Aslaa , Bakovic Allison , Risner Kenneth , Kortchak Stephanie , Der Torossian Torres Marcelo , de la Fuente-Nunez Cesar , Lu Timothy , Bhalla Nishank , Narayanan Aarthi 
Published: December 2020

AbstractVenezuelan equine encephalitis virus (VEEV), a New World alphavirus of the Togaviridae family of viruses causes periodic outbreaks of disease in humans and equines. Disease following VEEV infection manifests as a febrile illness with flu-like symptoms, which can progress to encephalitis and cause permanent neurological sequelae in a small number of cases. VEEV is classified as a category B select agent due to ease of aerosolization and high retention of infectivity in the aerosol form. Currently, there are no FDA-approved vaccines or therapeutics available to combat VEEV infection. VEEV infection in vivo is characterized by extensive systemic inflammation that can exacerbate infection by potentially increasing the susceptibility of off-site cells to infection and dissemination of the virus. Hence, a therapeutic targeting both the infection and associated inflammation represents an unmet need. We have previously demonstrated that host defense peptides (HDPs), short peptides that are key components of the innate immune response, exhibit antiviral activity against a multitude of viruses including VEEV. In this study, we designed synthetic peptides derived from indolicidin, a naturally occurring HDP, and tested their efficacy against VEEV. Two candidate synthetic peptides inhibited VEEV replication by approximately 1000-fold and decreased the expression of inflammatory mediators such as IL1α, IL1β, IFNγ, and TNFα at both the gene and protein expression levels. Furthermore, an increase in expression levels of genes involved in chemotaxis of leukocytes and anti-inflammatory genes such as IL1RN was also observed. Overall, we conclude that our synthetic peptides inhibit VEEV replication and the inflammatory burden associated with VEEV infection.
Theoretical investigation on $$\hbox {BeN}_{{2}}$$ monolayer for an efficient bifunctional water splitting catalyst
Authors: Kishore M. R. Ashwin , Varunaa R. , Bayani Amirhossein , Larsson Karin 
Published: December 2020

AbstractThe search for an active, stable, and abundant semiconductor-based bifunctional catalysts for solar hydrogen production will make a substantial impact on the sustainable development of the society that does not rely on fossil reserves. The photocatalytic water splitting mechanism on a $$\hbox {BeN}_{{2}}$$

BeN
2

monolayer has here been investigated by using state-of-the-art density functional theory calculations. For all possible reaction intermediates, the calculated changes in Gibbs free energy showed that the oxygen evolution reaction will occur at, and above, the potential of 2.06 V (against the NHE) as all elementary steps are exergonic. In the case of the hydrogen evolution reaction, a potential of 0.52 V, or above, was required to make the reaction take place spontaneously. Interestingly, the calculated valence band edge and conduction band edge positions for a $$\hbox {BeN}_{{2}}$$

BeN
2

monolayer are located at the potential of 2.60 V and 0.56 V, respectively. This indicates that the photo-generated holes in the valence band can oxidize water to oxygen, and the photo-generated electrons in the conduction band can spontaneously reduce water to hydrogen. Hence, the results from the present theoretical investigation show that the $$\hbox {BeN}_{{2}}$$

BeN
2

monolayer is an efficient bifunctional water-splitting catalyst, without the need for any co-catalyst.