bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entrepreneurial Firms and Bank Financing: Do Business Angels Play a Role?
Authors: Capizzi Vincenzo , Carta Nicola , Cavezzali Elisa , Rigoni Ugo 
Published: December 2024

ABSTRACTThis paper investigates the contribution provided by business angels' (BAs) post‐investment intervention to the interaction between young entrepreneurial firms and bank lending decisions within the entrepreneurial finance ecosystem. The analysis relies on a data set comprising 114 Italian BA‐backed firms over the 2010–2018 period, alongside 498 matched firms. We find evidence that BAs' support makes it easier for entrepreneurial firms to raise follow‐on bank financing. Additionally, we document the positive effects of both BAs' entrepreneurial experience and soft monitoring. These effects can be attributed to BAs' value‐added contributions and their role in mitigating information asymmetries perceived by debt providers.
Sleep of Nurses: A Comprehensive Scoping Review
Authors: Matricciani Lisa , Clarke Jarrod , Wiley Shelley , Williams Amelia , Baljak Gabriele Raine , Graham Kristin , Gum Lyn , Rogers Michelle , Howland Kirstie , Stewart Kiriaki , Ruf Hayley , Marnie Casey , Visvanathan Vickneswari , Singh Ben , Banks Siobhan , Kelly Michelle A. , Peters Micah D. J. 
Published: December 2024

ABSTRACTAimTo map the extent, range and nature of studies that examine sleep of nurses and identify how sleep has been examined in relation to the different aspects of nurses' health and nursing work and practice.DesignA scoping review.Data SourcesA search of five electronic databases including MEDLINE, Embase, EMcare, PsycINFO (using the Ovid platform) and Scopus was undertaken in May 2023 to identify primary studies that examined nurses' sleep.Review MethodsThis review was undertaken in accordance with the Joanna Briggs Institute methodology for scoping reviews and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses extension for Scoping Reviews (PRISMA‐ScR) Checklist.ResultsThis review included 1040 studies from a wide range of countries. Most studies were observational in design and examined nurses working in the acute care sector. Studies were mostly descriptive (32%) or discussed sleep as a workforce issue (21%) or lifestyle behaviour that is important for the health of nurses working clinically (27%). A range of different sleep parameters were examined, with sleep quality the focus of most studies, especially in relation to well‐being.ConclusionThere has been an exponential increase in the number of studies that examine nurses' sleep. Efforts to examine the sleep of nurses are beginning to align with contemporary understandings and methodological approaches to examining sleep.However, this field of research could benefit from better consistency in the definition and reporting of sleep, prioritising objective measures of sleep and improving understanding of the relative and combined importance of different dimensions of sleep.ImpactThis review provides a comprehensive overview of studies that examine nurses' sleep. Findings highlight areas of growing interest, areas in need of further research and methodological considerations to strengthen research in this field.Patient or Public ContributionNo patient or public contribution.Registration DOIhttps://doi.org/10.17605/OSF.IO/RZC4M.
Identifying Genes Associated With Proliferation, Immunity and Thrombosis in Paroxysmal Nocturnal Haemoglobinuria
Authors: Du Yali , Wang David , Hu Qinglin , Lai Zhizhen , Yang Chen , He Huiwen , Wang Shuqing , Zhang Huijuan , Chen Peng , Li Zepeng , Chen Miao , Han Bing 
Published: December 2024

ABSTRACTPIGA mutation cannot fully explain the proliferative advantage of abnormal clones and thrombosis tendency in paroxysmal nocturnal haemoglobinuria (PNH), and additional genes may play a role, justifying further investigation. CD59+ and CD59‐ peripheral blood mononuclear cells from six PNH patients were sorted and subjected to whole‐exon sequencing (WES) and whole‐transcriptome sequencing respectively. Six age‐ and sex‐matched healthy volunteers were enrolled as controls. Genes related to proliferation, immunity and thrombosis were selected by gene ontology (GO) analysis. The selected gene mutant alleles were then identified in the WES results for 40 patients and verified by the Sanger method in another 40 PNH patients. CD59+ and CD59‐ peripheral blood mononuclear cells from seven patients were sorted, and the RNA and protein expression levels of target genes were assessed via quantitative real‐time PCR (RT‐qPCR), flow cytometry and western blotting. The final selected genes were then related to clinical features to analyse. T‐cell activation–related genes were upregulated, whereas platelet degranulation, coagulation, haemostasis, leukocyte proliferation and platelet activation–related genes were downregulated in both CD59+ and CD59‐ cells. The mRNA or protein expression levels of SELP, FLT1, NRP1 and vWF were either different from those in healthy controls or different between CD59+ and CD59‐ cells. Moreover, platelet aggregation was greater in patients with mutations in these genes than in patients without such mutations. Except for PIGA, other genes may be involved in the proliferation and coagulopathy that occur in PNH patients.
Initiation and stability of self‐harm in adolescence and early adulthood: investigating social and aetiological factors in twins
Authors: Marzecki Filip , Ahmadzadeh Yasmin I. , Oginni Olakunle A. , Pingault Jean‐Baptiste , McAdams Thomas A. , Zavos Helena M. S. 
Published: December 2024

BackgroundAlmost one in five (18.8%) UK adolescents are estimated to self‐harm and many young people initiate self‐harm early (average age 13 years). Prevention of self‐harm should be informed by knowledge about risk factors (e.g. socio‐demographic indices), characteristics (i.e. motivation for self‐harm and help‐seeking behaviours), as well as relative aetiological genetic and environmental processes. Previous twin studies evidence both genetic and environmental influences on self‐harm. However, to date, there has been no genetically informed research on self‐harm aetiology across development, nor studies identifying risk factors for initiating self‐harm at a younger age.MethodsWe examined self‐harm in the Twins Early Development Study, a birth cohort twin study. Using clustered regression models, we tested associations of socio‐demographic factors and victimisation with lifetime self‐harm and age of self‐harm initiation, both reported at 21. To investigate stability and/or change in genetic and environmental influences on self‐harm we interpreted a multivariate Cholesky decomposition across ages ≤16, 21, and 26.ResultsSelf‐harm was more common in adolescence than early adulthood, and the incidence of self‐harm in early adulthood was low (1.4%). The most common motivation for self‐harm was ‘to get relief from a terrible state of mind’ (83.4%). Independent predictors of self‐harm and earlier initiation of self‐harm were being female, belonging to a gender and/or sexual minority group, and experience of bullying victimisation. Sexual minority status was still significantly associated with self‐harm after controlling for familial factors in co‐twin control analyses. The Cholesky decomposition showed stability in genetic influences and innovation in non‐shared environmental influences on self‐harm.ConclusionsAdolescence should be a key period for self‐harm interventions. Women, sexual, and gender minorities, and those experiencing victimisation may need targeted support early in adolescence. Furthermore, it should be acknowledged that different individuals can be at risk at different stages as environmental factors influencing self‐harm change across time.
Evaluation of Trap Crops and the Presence of the Predator Nabis americoferus for the Management of the Tarnished Plant Bug in Strawberries
Authors: Solà Cassi Mireia , Gonzalez Noémie , Dumont François , Provost Caroline , Lucas Eric 
Published: December 2024

ABSTRACTThe polyphagous tarnished plant bug (TPB), Lygus lineolaris (Palisot de Beauvois) (Hemiptera: Miridae), inflicts substantial damage to strawberries and to several other valuable crops, impacting both yield quantity and quality. Effective control strategies are crucial to mitigate these losses. This study aimed to elucidate TPB host preferences and reproductive behaviours under various integrated pest management approaches. Experimental arenas with strawberry plants included treatments involving the predator Nabis americoferus (Carayon) (Hemiptera: Nabidae) and trap crops. In each arena, 30 adult TPBs were exposed to different configurations: (i) three strawberry plants, (ii) three strawberry plants with predators, (iii) one strawberry plant alongside two trap crop plants (buckwheat and canola), and (iv) one strawberry plant with the two trap crops and predators. TPB distribution among the arena, plant species and plant sites (flower, stem and adaxial and abaxial leaves) were monitored over 72 h. One week later, adults were removed and the number of emerged first instar nymphs (L1) was recorded three times postexperiment. The results indicate a preference shift in TPB behaviour influenced by plant diversity and predator presence. TPBs exhibited a reduced presence on strawberries when trap crops were introduced, with canola as a preferred plant. This preference for canola was supported by higher TPB offspring counts. Conversely, buckwheat, although less preferred, contributed to diluting TPB populations across plant species. The introduction of N. americoferus showed dual effects: While reducing TPB oviposition on canola, it increased TPB presence on strawberries, highlighting the importance of nonconsumptive effects (NCEs) of predators in agroecosystems. Nonetheless, the combination of canola as a trap crop and N. americoferus as a predator effectively reduces TPB presence on strawberry flowers, essential for fruit development. This approach shows promise when integrated with other strategies, such as vacuuming and pheromone‐enhanced coloured traps.
Evaluation of the Accuracy of Digital Impression Techniques Based on an Integrated ADA Model
Authors: Piao Yongxu , Zhou Shuang , Zhang Rui , Gao Wenjia , Wang Mingchang , Kong Jiawen , Cai HongXin , Ma Chen , Jiang Heng Bo 
Published: December 2024

ABSTRACTObjectiveThe purpose of this in vitro study was to assess and compare the accuracy of three digital impression techniques based on an innovative integrated model.Materials and MethodsThe integrated model was created by incorporating crown, inlay, and long‐distance specimens from the American Dental Association (ADA) Standard No. 132. Digitized files of the model were acquired using three distinct impression techniques: intraoral scanner (IOS), extraoral scanner with negative cast (EOS_N), and extraoral scanner with positive cast (EOS_P). A coordinate measuring machine (CMM) was employed to establish the gold standard. The digital files of the model obtained via the extraoral scanner were designated the reference set for 3D fitting. Statistical analysis was performed using a one‐way analysis of variance and Tukey's posthoc test.ResultsFor the crown specimen, the relative error of EOS_N for indices d1 and d2 was higher than that of IOS and EOS_P. For the inlay specimen, IOS showed the highest trueness for d3 and h2. For the long‐distance specimen, IOS exhibited superior trueness for indices l1 and l3. EOS_N displayed the lowest trueness for l2. For l4, IOS had the largest relative error. No significant differences were observed among the three groups for l5 and l6. Notable deviations were evident in the 3D fitting maps at various locations in three experimental groups.ConclusionsThe three digital impression techniques exhibited varying capacities for capturing features of the integrated ADA model. For crown preparations, IOS and EOS_P are recommended, while for inlay preparations, no technology meets the standard requirements. IOS is recommended for partial impressions, while both EOS_N and EOS_P are suited for full‐arch impressions.
‘Pasteurised’ Tilapia: Drastic Mortality of Gyrodactylus cichlidarum During the Spring 2024 Heat Wave
Authors: Miranda‐Aguirre Julio Cesar , García‐Vásquez Adriana , Salazar‐Ulloa Martha , Muñoz‐Córdova Germán , Rubio‐Godoy Miguel 
Published: December 2024

ABSTRACTDuring spring 2024, a heat wave induced sustained water temperatures of 34°C during a week in Veracruz, Mexico. Serendipitously, we monitored Gyrodactylus cichlidarum infecting farmed tilapia fry during this pulse warming event and recorded a drastic decline of parasite populations over the following days. We subsequently established that parasites incubated in vitro at ca. 27°C survived up to 24 h, while at ca. 30°C and 34°C, all worms died within 4–7 h. Abnormal haptor structures were observed in parasites that developed and were born at a water temperature of 34°C. Under farming conditions, no unusual fish mortality was recorded, suggesting that pulse heat treatment may be an effective method to control G. cichlidarum, a recognised tilapia pathogen.
Do Extended Reality Interventions Benefit Patients Undergoing Elective Cardiac Surgical and Interventional Procedures? A Systematic Review and Meta‐analysis
Authors: Harris Emma , Fenton Steven , Stephenson John , Ewart Fiona , Goharinezhad Salime , Lee Hyunkook , Astin Felicity 
Published: December 2024

ABSTRACTBackgroundExtended reality (XR) interventions have the potential to benefit patients undergoing elective cardiac surgical and interventional procedures. However, there are no systematic reviews with meta‐analyses to guide clinical care.AimTo critically evaluate the evidence on the effectiveness of XR interventions on patient anxiety and pain and other associated outcomes.DesignSystematic review and meta‐analysis following the PRISMA 2020 statement.Data SourcesA systematic search of five databases (CENTRAL, CINAHL, MEDLINE, PsycInfo, Scopus) from inception to July 2023.MethodsScreening and data extraction was conducted independently by multiple reviewers. Stata (Version 17) was used to conduct meta‐analyses for patient anxiety and pain. Secondary patient outcomes were summarised in a synthesis. The Cochrane Risk of Bias (Version 2) tool was applied to trials and the NHLBI Study Quality Assessment tools to all other study designs.ResultsOf the 3372 records identified, 22 were included, 10 of which were eligible for inclusion in the meta‐analyses. Fifty‐seven percent of randomised trials were rated as high risk of bias. Virtual reality (VR) was the only XR technology evaluated. VR significantly reduced pre‐procedural anxiety (standardised mean difference: −1.29; 95% confidence interval − 1.96, −0.62, p < 0.001), and peri‐procedural anxiety (standardised mean difference: −0.50; 95% confidence interval − 0.83, −0.18, p < 0.003) but did not reduce pain levels, compared with usual care. VR increased pre‐procedural knowledge and postsurgical physical and pulmonary function. VR interventions may also improve emotional wellbeing, care delivery and physiological outcomes, but evidence was inconsistent.ConclusionsXR potentially benefits cardiac patients undergoing elective invasive procedures and surgery by reducing pre‐ and peri‐procedural anxiety and increasing procedural knowledge and physical function.Relevance to Clinical PracticeCardiac nurses' role can be supported by VR interventions to improve the patient experience and several aspects of patient care.Patient or Public ContributionNot applicable as this is a systematic review.
Psychological Distress, Antipsychotic Medications and Cardiovascular Risk Factors Among Patients With Schizophrenia
Authors: Al‐Dwaikat Tariq N. , Al‐Samouri Haya Khader , Dalky Heyam , Hamaideh Shaher H. , ALBashtawy Mohammed , Khatatbeh Haitham 
Published: December 2024

ABSTRACTAimsThis study aims to assess the correlation between antipsychotic drug use, psychological distress and cardiovascular risk factors among patients with schizophrenia.MethodsA cross‐sectional correlational design was used to obtain data from 143 patients with schizophrenia who were conveniently selected. Data were collected by assessing selected cardiovascular risk indicators blood pressure (BP), random blood sugar (RBS), body mass index (BMI), waist‐to‐height ratio (WtHR) and waist circumference (WC). A self‐administered questionnaire was used to collect sociodemographic data, clinical history and the 18‐item Psychological Stress Index for patients with schizophrenia.ResultsThe use of antipsychotics was associated with increased cardiovascular risk factors including BP, BMI and WtHR. Atypical antipsychotic medications were associated with weight gain and obesity which increase the risk of diabetes and cardiovascular diseases. Age was significantly correlated with systolic BP (r = 0.31), diastolic BP (r = 0.30) and RBS (r = 0.26). Furthermore, significant correlations were found between the duration of diagnosis with systolic (r = 0.26) and diastolic (r = 0.21) BP. None of the correlations between stress and the other study variables were significant.ConclusionScreening of antipsychotic side effects is needed in the early phases, and attention must be paid to the cardiovascular risk in patients with schizophrenia, particularly BP, glucose level and BMI. In addition, clinicians should be informed of this evidence to set guidelines for regular monitoring of metabolic parameters.Reporting MethodSTROBE guidelines were followed in this study.Patient or Public ContributionActively involving patients in data collection, this study ensured that their voices were heard and their experiences were central to informing the research findings. In addition, involving patients in the study would enhance the relevance and applicability of the study's conclusions to real‐world contexts, promoting patient‐centered care and improved health outcomes for patients with schizophrenia.
The Role of the Simulation in Supporting Newly Graduated Nurses in Their First 5 Months of Working Transition: Findings From a Mixed‐Method Study
Authors: Mesaglio Maura , Dentice Sara , Grassetti Luca , Achil Illarj , Bernardinis Anna , Caruzzo Davide , Inserra Anna , Mansutti Irene , Mattiussi Elisa , Menegoz Sandra , Piani Tommaso , Vanzo Elena , Chiappinotto Stefania , Palese Alvisa 
Published: December 2024

ABSTRACTAimsTo understand the role of simulation in ensuring the development of the competencies expected by newly graduated register nurses (NGRNs) from the work initiation up to 5 months of transition.MethodsMixed‐method study design. A longitudinal phase employing the Nurse Competence Scale (NCS, from 0 to 100, excellent) to assess the perceived competencies among NGRNs (N = 151) at three time points (first day of work up to fifth month); followed by a qualitative phase involving four focus groups of preceptors (N = 16) to explore the potential role of simulation in the NGRNs' working transition. Integration was performed at findings level, using the building procedures and joint displaying the results.ResultsDuring the different time periods, variations emerged in the NCS scores from 64.41 out of 100 in the first day of work to 61.82 after 15 days, reaching 69.25 and 73.21 at 3 and 5 months. Nine potentialities have been identified as having simulation supporting NGRNs during their transition to independent practice. Simulation may contribute to develop competencies in some competence domains (diagnostic function, managing situation, therapeutic intervention, quality assurance and working role) while not in others (helping role and teaching–coaching).ConclusionEarly interventions, through integration of simulation sessions into strategies offered at the unit's level may be useful to ensure an effective working transition.ImpactProblem the study addresses: Challenges in transition from education to working settings are increasing given the difficulties of the units in providing time and support to NGRNs. Main findings: Competencies of NGRNs' are fluctuant in the five first months of work, and sub‐optimal in certain domains. Simulation may support the full development of most competencies. Impact on research: Healthcare organisations can support NGRNs to ensure smoother transitions by integrating simulations in their strategy.Reporting MethodThis study was conducted following the Good Reporting of a Mixed‐Methods Study.Patient or Public ContributionOnly healthcare professionals were involved.
Adenomyosis with uterine abscess formation treated by adenomyomectomy: A report of two cases
Authors: Hiratsuka Daiki , Ishizawa Chihiro , Iida Rei , Fukui Yamato , Matsuo Mitsunori , Nishida Masato , Ikemura Masako , Harada Miyuki , Wada‐Hiraike Osamu , Osuga Yutaka , Hirota Yasushi 
Published: December 2024

AbstractUterine adenomyosis is a common disease in women of reproductive age that causes dysmenorrhea, abnormal uterine bleeding, infertility, and obstetric complications. Rarely, adenomyosis can lead to abscess formation, which is refractory to antibiotics and occasionally requires surgical treatment, such as hysterectomy. However, hysterectomy should be avoided in patients who seek to preserve fertility. Herein, for the first time, we report two cases of uterine adenomyosis with abscess formation during assisted reproductive procedures that were successfully treated with adenomyomectomy, thereby preserving fertility. A history of repeated intrauterine procedures and infections was crucial in making an appropriate preoperative diagnosis. Adenomyomectomy can be an effective treatment for adenomyosis associated with abscess in patients who wish to preserve fertility.
Negative emotions, difficult conversations and leader–follower relationships
Authors: Williams Courtney E. , Thomas Jane Shumski , Gooty Janaki , Dunne Danielle D. 
Published: December 2024

AbstractThe world of work is replete with daily hassles that make the experience of negative emotions ubiquitous. Conversations between leaders and followers during challenging times are often characterized by negative emotions, and thus, are of central importance in modern organizations. Yet, the intersection of negative emotion, difficult conversations and leader–follower relationships is often ignored, and these topics are treated as separate areas of study. We integrate these various streams with research on asymmetrical leader negative emotion displays to identify when and how difficult conversations laden with negative emotions result in benefits to leader–follower relationships. Using a grounded theory approach, we build a theoretical model based on interviews with 21 leaders and 17 followers describing 166 difficult conversations. Our work depicts specific communication strategies that leaders use to facilitate difficult conversations. These strategies, in turn, create shared meaning and validate followers' feelings during difficult conversations, which allows for beneficial relationship‐specific outcomes to ensue. We unpack these findings in the context of the power differential between leaders and followers to advance current thinking on the intersection of negative emotions and communication in leader–follower relationships.