bluuebunny/crossref_metadata_2025_split huggingface dataset:
The fidelity and dose of message delivery on infant and young child feeding practice and nutrition sensitive agriculture in Ethiopia: a qualitative study from the Sustainable Undernutrition Reduction in Ethiopia (SURE) programme
Authors: Salasibew Mihretab M. , Moss Cami , Ayana Girmay , Kuche Desalegn , Eshetu Solomon , Dangour Alan D. 
Published: October 2019

Abstract

Background
In Ethiopia, 38% of children under 5 years of age are stunted (low height for age). A novel government-led intervention called the Sustainable Undernutrition Reduction in Ethiopia (SURE) aims to tackle the burden of stunting by improving complementary feeding and dietary diversity among young children. The SURE programme design applies a transtheoretical model of behaviour change, whereby exposure to recommended infant and young child feeding (IYCF) and nutrition-sensitive agriculture messages is a first stage to adopting key behaviours. This qualitative study explored the fidelity and dose of the IYCF and nutrition-sensitive agriculture messages delivered by extension workers.

Methods
A qualitative study was conducted across four regions in Ethiopia (Oromiya, Amhara, SNNP and Tigray) between April and October 2017. Across the four regions, 81 key informant interviews, 90 FGDs and 81 observations were conducted with 180 extension workers, 18 development agents and 54 mother-father pairs. Digitally recorded audio files were transcribed verbatim, and the data were analysed based on a framework analysis approach using NVivo (version 12) by coding and categorising texts into major themes and sub-themes.

Results
SURE target households had the intended exposure to messages about exclusive breastfeeding, timing of initiation of complementary feeding, food groups, diversified food consumption, irrigation, rearing small animals and vegetables. Few households reported receiving messages on the content or frequency of complementary feeding of a child beyond 6 months of age. Frequency of household visits and hence exposure to SURE messages was also variable. Agricultural messages delivered during household visits focussed on improving standard agricultural practices and rarely covered the importance of nutrition-sensitive agriculture to improve household or child nutrition.

Conclusion
Despite variability observed in the breadth and depth of messages delivered, large-scale behaviour change communication programmes can achieve moderate to good message exposure among target groups. Qualitative data provide an in-depth insight into fidelity and may supplement our understanding of programme roll-out and implementation. Further research is required to understand longer-term message saturation including frequency and reach.
Production of a Spirulina sp. algae hybrid with a silica matrix as an effective adsorbent to absorb crystal violet and methylene blue in a solution
Authors: Buhani  , Suharso  , Aditiya Ismi , Al Kausar Radho , Sumadi  , Rinawati  
Published: October 2019

Abstract
In this study, the adsorbent of Crystal Violet (CV) and Methylene Blue (MB) dyes was synthesized from the hybridization of Spirulina sp. algae biomass with silica as a matrix (ASS). Hybridization of Spirulina sp. algae biomass was carried out through a sol-gel process using tetraethyl orthosilicate precursors. The ASS adsorbent was characterized using Fourier-transform infrared spectroscopy, X-ray diffraction, Brunauer-Emmett-Teller surface area method and scanning electron microscopy-energy-dispersive-X ray. The CV and MB dyes adsorption onto ASS adsorbent was studied through adsorption experiments using the batch method. The optimum adsorption of CV and MB dyes is at pH of 8 and contact time of 60 min. The CV and MB dye kinetics on the ASS adsorbent tend to follow the pseudo-second-order kinetics model with rate constant (k2) of 0.3 and 0.2 (g mg− 1 min− 1) respectively. The isotherm adsorption pattern of CV and MB dyes follows the Freundlich adsorption isotherm with KF values of 1.07 and 1.05 (mg g− 1) (L mg− 1)1/n, respectively. In the simultaneous adsorption process, CV dyes were more adsorbed than MB in solution to the ASS adsorbent.
Applying Data Warehousing to a Phase III Clinical Trial From the Fondazione Italiana Linfomi Ensures Superior Data Quality and Improved Assessment of Clinical Outcomes
Authors: Zaccaria Gian Maria , Ferrero Simone , Rosati Samanta , Ghislieri Marco , Genuardi Elisa , Evangelista Andrea , Sandrone Rebecca , Castagneri Cristina , Barbero Daniela , Lo Schirico Mariella , Arcaini Luca , Molinari Anna Lia , Ballerini Filippo , Ferreri Andres , Omedè Paola , Zamò Alberto , Balestra Gabriella , Boccadoro Mario , Cortelazzo Sergio , Ladetto Marco 
Published: October 2019

PURPOSE Data collection in clinical trials is becoming complex, with a huge number of variables that need to be recorded, verified, and analyzed to effectively measure clinical outcomes. In this study, we used data warehouse (DW) concepts to achieve this goal. A DW was developed to accommodate data from a large clinical trial, including all the characteristics collected. We present the results related to baseline variables with the following objectives: developing a data quality (DQ) control strategy and improving outcome analysis according to the clinical trial primary end points. METHODS Data were retrieved from the electronic case reporting forms (eCRFs) of the phase III, multicenter MCL0208 trial (ClinicalTrials.gov identifier: NCT02354313 ) of the Fondazione Italiana Linfomi for younger patients with untreated mantle cell lymphoma (MCL). The DW was created with a relational database management system. Recommended DQ dimensions were observed to monitor the activity of each site to handle DQ management during patient follow-up. The DQ management was applied to clinically relevant parameters that predicted progression-free survival to assess its impact. RESULTS The DW encompassed 16 tables, which included 226 variables for 300 patients and 199,500 items of data. The tool allowed cross-comparison analysis and detected some incongruities in eCRFs, prompting queries to clinical centers. This had an impact on clinical end points, as the DQ control strategy was able to improve the prognostic stratification according to single parameters, such as tumor infiltration by flow cytometry, and even using established prognosticators, such as the MCL International Prognostic Index. CONCLUSION The DW is a powerful tool to organize results from large phase III clinical trials and to effectively improve DQ through the application of effective engineered tools.
The New Biology of Diabetic Kidney Disease—Mechanisms and Therapeutic Implications
Authors: Lytvyn Yuliya , Bjornstad Petter , van Raalte Daniel H , Heerspink Hiddo L , Cherney David Z I 
Published: October 2019

AbstractDiabetic kidney disease remains the most common cause of end-stage kidney disease in the world. Despite reductions in incidence rates of myocardial infarction and stroke in people with diabetes over the past 3 decades, the risk of diabetic kidney disease has remained unchanged, and may even be increasing in younger individuals afflicted with this disease. Accordingly, changes in public health policy have to be implemented to address the root causes of diabetic kidney disease, including the rise of obesity and diabetes, in addition to the use of safe and effective pharmacological agents to prevent cardiorenal complications in people with diabetes. The aim of this article is to review the mechanisms of pathogenesis and therapies that are either in clinical practice or that are emerging in clinical development programs for potential use to treat diabetic kidney disease.
Yap induces osteoblast differentiation by modulating Bmp signalling during zebrafish caudal fin regeneration
Authors: Brandão Ana S. , Bensimon-Brito Anabela , Lourenço Raquel , Borbinha Jorge , Soares Ana Rosa , Mateus Rita , Jacinto António 
Published: October 2019

ABSTRACT
Osteoblast differentiation is a key process for bone homeostasis and repair. Multiple signalling pathways have been associated with osteoblast differentiation, yet much remains unknown on how this process is regulated in vivo. Previous studies have proposed that the Hippo pathway transcriptional co-activators YAP and TAZ (also known as YAP1 and WWTR1, respectively) maintain progenitor stemness and inhibit terminal differentiation of osteoblasts, whereas others suggest they potentiate osteoblast differentiation and bone formation. Here, we use zebrafish caudal fin regeneration as a model to clarify how the Hippo pathway regulates de novo bone formation and osteoblast differentiation. We demonstrate that Yap inhibition leads to accumulation of osteoprogenitors and prevents osteoblast differentiation in a cell non-autonomous manner. This effect correlates with a severe impairment of Bmp signalling in osteoblasts, likely by suppressing the expression of the ligand bmp2a in the surrounding mesenchymal cells. Overall, our findings provide a new mechanism of bone formation through the Hippo–Yap pathway, integrating Yap in the signalling cascade that governs osteoprogenitor maintenance and subsequent differentiation during zebrafish caudal fin regeneration.
Role for the splicing factor TCERG1 in Cajal body integrity and snRNP assembly
Authors: Moreno-Castro Cristina , Prieto-Sánchez Silvia , Sánchez-Hernández Noemí , Hernández-Munain Cristina , Suñé Carlos 
Published: October 2019

ABSTRACT
Cajal bodies are nuclear organelles involved in the nuclear phase of small nuclear ribonucleoprotein (snRNP) biogenesis. In this study, we identified the splicing factor TCERG1 as a coilin-associated factor that is essential for Cajal body integrity. Knockdown of TCERG1 disrupts the localization of the components of Cajal bodies, including coilin and NOLC1, with coilin being dispersed in the nucleoplasm into numerous small foci, without affecting speckles, gems or the histone locus body. Furthermore, the depletion of TCERG1 affects the recruitment of Sm proteins to uridine-rich small nuclear RNAs (snRNAs) to form the mature core snRNP. Taken together, the results of this study suggest that TCERG1 plays an important role in Cajal body formation and snRNP biogenesis.
Novel role of proton-secreting epithelial cells in sperm maturation and mucosal immunity
Authors: Battistone Maria A. , Spallanzani Raul German , Mendelsohn Alexandra C. , Capen Diane , Nair Anil V. , Brown Dennis , Breton Sylvie 
Published: October 2019

ABSTRACT
Epithelial cells are immune sensors and mediators that constitute the first line of defense against infections. Using the epididymis, a model for studying tubular organs, we uncovered a novel and unexpected role for professional proton-secreting ‘clear cells’ in sperm maturation and immune defense. The epididymal epithelium participates in the maturation of spermatozoa via the establishment of an acidic milieu and transfer of proteins to sperm cells, a poorly characterized process. We show that proton-secreting clear cells express mRNA transcripts and proteins that are acquired by maturing sperm, and that they establish close interactions with luminal spermatozoa via newly described ‘nanotubes’. Mechanistic studies show that injection of bacterial antigens in vivo induces chemokine expression in clear cells, followed by macrophage recruitment into the organ. Injection of an inflammatory intermediate mediator (IFN-γ) increased Cxcl10 expression in clear cells, revealing their participation as sensors and mediators of inflammation. The functional diversity adopted by clear cells might represent a generalized phenomenon by which similar epithelial cells decode signals, communicate with neighbors and mediate mucosal immunity, depending on their precise location within an organ.
This article has an associated First Person interview with the first author of the paper.
Perspectives of Clinicians, Staff, and Veterans in Transitioning Veterans from non‐VA Hospitals to Primary Care in a Single VA Healthcare System
Authors: Ayele Roman A , Lawrence Emily , McCreight Marina , Fehling Kelty , Glasgow Russell E , Rabin Borsika A , Burke Robert E , Battaglia Catherine 
Published: October 2019

BACKGROUNDVeterans with healthcare needs utilize both Veterans Health Administration (VA) and non‐VA hospitals. These dual‐use veterans are at high risk of adverse outcomes due to the lack of coordination for safe transitions.OBJECTIVESThe aim of this study was to understand the barriers and facilitators to providing high‐quality continuum of care for veterans transitioning from non‐VA hospitals to the VA primary care setting.DESIGNGuided by the practical robust implementation and sustainability model (PRISM) and the ideal transitions of care, we conducted a qualitative assessment using semi‐structured interviews with clinicians, staff, and patients.SETTINGThis study was conducted at a single urban VA medical center and two non‐VA hospitals.PARTICIPANTSA total of 70 participants, including 52 clinicians and staff (23 VA and 29 non‐VA) involved in patient transition and 18 veterans recently discharged from non‐VA hospitals, were included in this study.APPROACHData were analyzed using a conventional content analysis and managed in Atlas.ti (Berlin, Germany).RESULTSFour major themes emerged where participants consistently discussed that transitions were delayed when they were not able to (1) identify patients as veterans and notify VA primary care of discharge, (2) transfer non‐VA hospital medical records to VA primary care, (3) obtain follow‐up care appointments with VA primary care, and (4) write VA formulary medications for veterans that they could fill at VA pharmacies. Participants also discussed factors involved in smooth transition and recommendations to improve care coordination.CONCLUSIONSAll participants perceived the current transition‐of‐care process across healthcare systems to be inefficient. Efforts to improve quality and safety in transitional care should address the challenges clinicians and patients experience when transitioning from non‐VA hospitals to VA primary care.
KIRMIZI PUL BİBER ÖRNEKLERİNDE ELEMENT İÇERİĞİNİN BELİRLENMESİ
Authors: KILIÇ Serpil , KILIÇ Murat 
Published: October 2019

Çevresel kirlilikler, tarım ürünlerini tehdit etmekte ve
dolayısıyla insan sağlığı için risk oluşturmaktadır. Bu tarım ürünleri
içerisinde yer alan, kırmızıbiber, üretiminde kimyasal ilaçların kullanımı ise
sağlık için tehlike oluşturan bazı elementlerin kontamine olmasına sebep
olabilmektedir. Gıda sanayinde yaygın olarak kullanılan bir baharat çeşidi olan
ve özellikle gıdaları çeşnilendirmek için en çok kullanılan baharatlar arasında
yer alan kırmızıbiber tüketiminde, bu kontaminasyon insan sağlığını tehdit
edici unsur oluşturmaktadır. Bu çalışmada, kırmızıbibere kontamine olabilen
bazı metal kirleticiler (krom (Cr), kobalt (Co), bakır (Cu), demir (Fe), nikel
(Ni), selenyum (Se), çinko (Zn)) indüktif eşleşmiş plazma kütle spektrometrisi
kullanılarak (ICP-MS) tespit edildi.
Analitik performansları; doğrusallık, tespit sınırı, ölçüm sınırı ve
geri kazanım olarak değerlendirildi. Metot validasyonu için sertifikalı
referans madde olarak Tomato Leaves 1573a kullanıldı. Çalışılan elementler için
geri kazanım,%98 ile %103 arasında değişmektedir. Örneklerde tüm metallerin
konsantrasyonları uluslararası ve Türk Gıda Kodeksinde belirtilen sınırları
aşmadığı gözlemlenmiştir.
EDITORIAL
Authors: Berto Nilo 
Published: October 2019

Quadragésimo ano (II) "Os vossos cadáveres cairão neste deserto e vossos filhos andarão errantes neste deserto durante quarenta anos, carregando o peso de vossa infidelidade, até que vossos cadáveres se consumam no deserto. Explorastes a terra durante dias. A cada dia corresponde um ano: por quarenta anos levareis o peso de vossas faltas" (Núm 14, 32- 34). Foi assim que Israel pagou por quarenta anos suas infidelidades e insatisfações perante seu Senhor, até chegar a seu destino. Sem ter que cumprir terrível sentença condenatória, com prazo fatal, exarada com tintas negras e cominatórias e em linguagem crua e realista - tão própria do estilo veterotestamentário - e apenas cumprindo um programa e perseguindo uma ideia de seu fundador, VERITAS chega ao quadragésimo ano de sua existência, lança um olhar retrospectivo sobre seu passado e rememora, quadragenária, os oito lustros que perlustrou desde 1955.
Phase II Study on Biweekly Combination Therapy of Gemcitabine plus Carboplatin for the Treatment of Elderly Patients with Advanced Non-Small Cell Lung Cancer
Authors: Takayama Koichi , Ichiki Masao , Matsumoto Takemasa , Ebi Noriyuki , Akamine Shinji , Tokunaga Shoji , Yamada Tadaaki , Uchino Junji , Nakanishi Yoichi 
Published: October 2019

Abstract

Lessons Learned
The biweekly GEM plus CBDCA dose and schedule showed satisfactory efficacy with mild toxicities in elderly patients with advanced NSCLC. The biweekly GEM plus CBDCA regimen could be considered an alternative to the 3-week regimen in NSCLC.

Background
The gemcitabine (GEM)-carboplatin (CBDCA) combination is widely used for non-small cell lung cancer (NSCLC) and has some efficacy in elderly patients; however, a high incidence of thrombocytopenia is observed, and the optimal dosage and administration schedules are unknown. This multicenter phase II trial evaluated the efficacy and tolerability of GEM-CBDCA for elderly patients with chemotherapy-naive NSCLC.

Methods
Patients with chemotherapy-naive performance status 0–1 and with stage IIIB/IV NSCLC were administered chemotherapy biweekly (GEM 1,000 mg/m2 with CBDCA area under the blood concentration-time curve (AUC) 3 on days 1 and 15 every 4 weeks). The primary endpoint was the objective response rate (ORR), and the secondary endpoints were progression-free survival (PFS), overall survival (OS), and safety.

Results
Forty-eight patients were enrolled. Median age was 76 years (range, 70–83); 35 patients were men (73%), and 27 patients had adenocarcinoma (56%). The ORR was 29.2% (95% confidence interval [CI], 17.0–44.1). The median PFS, median OS, and 1-year survival was 5.9 months (95% CI, 4.1–6.6), 13.3 months (95% CI, 8.3–23.5), and 58%, respectively. Grade ≥3 hematological toxicities included neutropenia (29.2%), thrombocytopenia (4.2%), and anemia (20.8%). The incidence of grade ≥3 nonhematological toxicities was &lt;5%.

Conclusion
This GEM-CBDCA combination administered biweekly showed satisfactory efficacy with mild toxicities in elderly patients with advanced NSCLC.
Severe generalized dystonia in paediatric onset wilsons disease
Authors: A. Jyothi , K. Subramanya N. 
Published: October 2019

Wilson disease (WD) is a rare autosomal recessive disorder with defect in copper transport mechanism with varied clinical manifestation predominantly hepatic, neurological, ophthalmological and multi-systemic involvement. WD in paediatrics age group manifest differently from the adults. In this case report, Authors have described the first case report presenting with neurological involvement in the form of severe generalized dystonia in a paediatric onset WD. This case report is of greater significance in detecting the most often undetected paediatric WD presenting with a usual hepatic manifestation occurring early in the course.
Eruptive syringoma: a case report
Authors: Saikia Siddhartha S. , Jagati Ashish G. , Rathod Santoshdev P. , Chaudhary Raju G. 
Published: October 2019

<p class="MsoNormal" style="margin-top: 12.0pt; line-height: normal;">Eruptive syringoma is a rare clinical presentation of a benign tumor of the eccrine ducts. Its usual presentation is small, smooth, skin coloured papules with flattened or rounded tops on the anterior body surfaces including face. It usually affects adult female. Treatment of this benign condition is cosmetic only. Herein, we report an uncommon presentation in a 30 years old female who presented with multiple, asymptomatic, skin coloured papules over face, neck, chest and thighs. Histopathology showed collection of cystic ducts and epithelial cords with comma like tails in dermis confirming a diagnosis of eruptive syringomas. </p>
PATOLOJİK LENFADENOPATİLERDE KLİNİK, LABORATUAR, ULTRASON BULGULARI İLE HİSTOPATOLOJİ SONUÇLARININ KARŞILAŞTIRILMASI
Authors: Kesik Pınar , Acıpayam Can , Temiz Fatih , Yurttutan Nursel , Güler Ahmet Gökhan , Sayar Hamide , Kandemir Gülmez Tuğba 
Published: October 2019

Amaç: Lenfadenopatilerde malignite
çıkma olasılığı %1-3 oranındadır ve en
sık lenfomalar gözlenir. Ultrasonografi ayırıcı tanıda hekime bazı bulguları
ile malignite yönünde yardımcı olabilir. Tanısı kesinleştirilememiş, malignite
düşünülen vakalarda biyopsi yapılması esastır. Bu çalışmada patolojik lenfadopatili hastaların sosyo demografik verileri
klinik laboratuvar, ultrason bulguları
ve histopatoloji sonuçlarının karşılaştırılması hedeflenmiştir.

Yöntemler: Bu
çalışmada Kahramanmaraş Sütçü İmam Tıp Fakültesi Hastanesi’ne Ocak 2014 ve
Eylül 2016 tarihleri arasında başvuran 857 lenfadenopatili hastadan (328
kız-529 erkek) 50 adet (39’u erkek, 11’i
kız) patolojik lenfadenopatili hasta geriye dönük olarak değerlendirildi.

Bulgular: Patolojik
lenfadenopati tanılı 50 hastanın yaşları 12-192 ay arasında değişmektedir.
Hastaların 24’ünde lenfadenopati boyutu 3 cm’nin üzerindeydi.
Lenfadenopatilerden 35’i servikal, 15’i ise servikal dışı lokalizasyona
sahipti. Bu hastalardan 35’ine reaktif, 15’ine ise non-reaktif USG sonucu
saptandı. Hastalardan 38’inde benign hastalık, 12’sinde ise malignite saptandı.
Yapılan istatistiksel analizler neticesinde patoloji sonuçları ile USG özelliği
arasında ve aynı zamanda lenfadenopati boyutu ile USG’de tespit edilen boyut
arasında anlamlı bir ilişki saptandı (p&lt;0,05). Çalışmamız da bening ve
malign olanların USG özelliği ve ateş açısından karşılaştırılmasında benign
olanların 12’sinde (%31,6), malign olanların ise 9’unda (%75) ateş söz konusu
olup gruplar arasında ateş varlığı açısından anlamlı farklılık vardır
(p&lt;0,05).

Sonuç: Lenfadenopati
ile başvuran olgularda öykü ve fizik incelemeden sonra lenfadenopatinin ciddi
bir hastalığın belirtisi olup olmadığı araştırılmalıdır.
EKİNOKOKUS KİSTİNİN TEDAVİSİNDE RADYOFREKANS TERMAL ABLASYON (RTA): EX-VİVO HAYVAN MODELİNDE DENEYSEL BİR ÇALIŞMA
Authors: Dumanlı Ahmet , Apilioğulları Burhan , Ceran Sami , Özbek Orhan , Esen Hasan , Feyzioğlu Bahadır 
Published: October 2019

AMAÇ: Radyofrekans
termal ablasyon (RTA), diğer komorbiditeleri olan inoperabl hastalarda sıklıkla
kullanılan minimal invaziv bir tekniktir. Eks vivo çalışmanın amacı, hayvan
modellerinde (eksplante edilen organlar) akciğer kistik ekinokokkozun
tedavisinde RTA'nın farklı sıcaklık ve sürelerinin etkinliğini
değerlendirmektir.

GEREÇ VE YÖNTEM:
Enfekte sığır akciğerleri toplandı. 9 adet sığır akciğerinde bulunan 45 adet
canlı kist kullanıldı. Canlı akciğer kistlerinin radyofrekans tedavi grupları ısıya göre,
rasgele üç ana gruba ayrıldı. Grup 1 (n = 15) 90°C 'de, grup 2 (n = 15) 100°C
'de ve grup3 (n = 15) 110 °C 'de. Gruplar radyofrekans uygulama süresine göre,
üç alt gruba ayrıldı (7 dakika n = 5; 9 dakika n = 5; 11 dakika n = 5).
Tedaviden sonra tüm kistler çıkarıldı ve patolojik olarak incelendi. Eğer
patolojik olarak korunmuş bir germinal membran mevcut ise kistler canlı olarak
değerlendirildi. Germinal membran nekrotik ise başarılı bir şekilde tedavi
edilmiş olarak değerlendirildi.

BULGULAR: RTA
uygulanan 45 numunenin 41'nin patolojik
kesitlerinde germinal membran kısmi
olarak nekrotik durumdaydı ve
canlı olarak değerlendirildi. Sadece 4
numunede tamamen nekrotik germinal membran mevcuttu ve 11 dakikada 110 ° C'de
başarılı bir şekilde tedavi edildi. Yıkım oranı, RTA’da uygulanan ısı artışıyla
pozitif korelasyon göstermektedir (Phi = 0.89, p = 0.006).

SONUÇ: 110 ° C'ye
kadar RTA uygulaması kist hidatiklerin öldürülmesinde etkili olmayabilir. Bu
tekniğin, insanda kistik ekinokokkoz tedavisi olarak kabul edilmeden önce hala
büyük miktarda ek klinik öncesi çalışma gerektirmektedir.