bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical Reconstruction Options in Chronic Distal Biceps Tendon Ruptures – Case Report and Literature Review
Authors: Riesner Hans-Joachim , Hackenbroch Carsten , Lang Patricia , Achatz Gerhard , Palm Hans-Georg , Friemert Benedikt 
Published: November 2019

Abstract
Introduction Chronic distal biceps tendon ruptures are rare and conservative or operative treatment options are suitable. There is a consensus in the literature in case of acute traumatic ruptures the operative refixation should be preferred. Disagreement exists in the best way of care of old ruptures (> 4 weeks) of distal biceps tendon. Several kinds of refixation possibilities up to tendon grafts are described. Aim of this publication is showing an overview of the literature of the approved methods in reconstruction of the distal biceps tendon using autogenous and allogenic grafts, comparing the outcomes and transferring them on an own case.
Material and Methods A literature research was carried out using the online medical database “PubMed” with the following keywords “chronic rupture distal biceps tendon, surgical techniques”. 59 citations were found concerning the topic, 37 publications were relevant for this work.
Results There is consensus that even in chronic ruptures the operative management of the distal biceps tendon generates the best results. Consistently the experiences and results of only little patient collectives are reported. Numerous techniques of surgery are described without predominance of one method. Reinsertions of the tendon butts are reported in different techniques: with achilles, palmaris longus, fascia lata, triceps, quadriceps and semitendinosus tendon grafts. All together they showed postoperative satisfactory results.
Conclusion With surgical treatment of chronic ruptured distal biceps tendons comparable outcomes can be achieved by primary refixation and graft augmentations. In case of graft augmentations several tissue options are available which showed in all cases satisfactory functional results in the end.
Hyperuricemia Inhibition Protects SD Rats Against Fructose-Induced Obesity Hypertension Via Modulation of Inflammation and Renin-Angiotensin System in Adipose Tissue
Authors: Zhang Jun Xia , Lin Xue , Xu Jinxiu , Tang Feng 
Published: November 2019

Abstract
Objective The present study was aimed to reveal the relationship between uric acid and fructose-induced obesity hypertension and its mechanisms.
Methods A rat model with obesity hypertension was induced by a high-fructose diet. In the experiment I, the rats were fed with fructose for 8 wks along with allopurinol or benzbromarone at the beginning. In the experiment II, the rats were fed with fructose for 8 wks firstly. And then, these rats were treated with allopurinol or benzbromarone for additional 6 wks.
Results Fructose-fed rats showed hyperuricemia, abdominal obesity hypertension and an activation in adipose renin-angiotensin system (RAS). Also, fructose-fed rats had higher levels of proinflammatory cytokines and more macrophages infiltrating in adipose tissue. In the experiment I, allopurinol and benzbromarone significantly reduced serum uric acid at 8 wk. Adipose RAS overactivation, adipose inflammatory responses and the development of obesity hypertension were all effectively prevented by hyperuricemia inhibition. In the experiment II, 6-wk treatment with allopurinol and benzbromarone significantly decreased serum uric acid, downregulated adipose RAS, abolished adipose inflammation and improved obesity hypertension.
Conclusion In conclusion, urate-lowering therapy protects rats against fructose-induced obesity hypertension. The mechanisms appear to be via downregulated adipose RAS and reduced inflammation in adipose tissue.
DNVF-Memorandum – Gesundheits- und Medizin-Apps (GuMAs)
Authors: Kramer Ursula , Borges Uirassu , Fischer Florian , Hoffmann Wolfgang , Pobiruchin Monika , Vollmar Horst Christian 
Published: November 2019

ZusammenfassungDas Memorandum adressiert Fragestellungen wie Angebot, objektiven Bedarf und Nettonutzen von Gesundheits- und Medizin-Apps (GuMAs), ethische Standards und Risiken, die von der Versorgungsforschung durch geeignete methodische Ansätze untersucht und beantwortet werden sollten. Diese Fragestellungen beziehen sich auf die Aspekte Patientensicherheit, Prozess- und Ergebnisqualität, versorgungsrelevante Aspekte digitaler Anwendungen und deren Einsatz in und für die wissenschaftliche Forschung.
Presentación clínico-patológica del adenocarcinoma prostático en un Hospital de tercer nivel en Colombia
Authors: Lecompte-Osorio Paola , Lázaro Andrés , Benedetti Inés 
Published: November 2019

ResumenObjetivo Mundialmente, el cáncer de próstata es la segunda neoplasia maligna más frecuente en hombres a nivel mundial y la primera en Colombia. Se determinaron las características clínico-patológicas de los casos de cáncer de próstata diagnosticados en un hospital de la región caribe colombiana.Métodos Se realizó un estudio retrospectivo en la Facultad de Medicina de la Universidad de Cartagena, Colombia. Se analizaron las características clínicas y patológicas de todos los pacientes diagnosticados con cáncer de próstata en el Hospital Universitario del Caribe durante los años 2007 a 2014.Resultados Se documentaron 394 casos, con edad promedio de 71,13 años (DE ± 8,25). El puntaje de Gleason fue mayor o igual a 8 en el 31,7%. En biopsias hubo localización bilateral del tumor en un 73,5% y compromiso tumoral mayor al 40% del tejido en el 73,2% de los casos. En un 5,8% de los pacientes, hubo valores de PSA normales. Se dio una asociación estadísticamente significativa entre el PSA y el examen digital rectal (p = 0,0009), puntaje de Gleason (p < 0,0001) y porcentaje de compromiso tumoral en biopsias (p < 0,0012). La combinación PSA más examen digital rectal obtuvo una sensibilidad del 96%.Conclusiones Gran parte de los casos de cáncer de próstata se diagnostican en estadios avanzados. La mayor sensibilidad para el diagnóstico clínico la tiene el uso del PSA más el examen digital rectal, sin dejar de lado la experiencia clínica que permite diagnosticarlo aún con PSA o examen digital rectal normales. Esos hallazgos deben promover la educación de la población.
Influence of Intensive Care Unit Enlightenment on Premature Infants on Functional Brain Maturation Assessed by Amplitude-Integrated Electroencephalograph
Authors: Tandircioglu Umit Ayse , Guzoglu Nilufer , Gucuyener Kivilcim , Aliefendioglu Didem 
Published: November 2019

Abstract
Objective Amplitude-integrated electroencephalograph (aEEG) presents a valuable tool for functional brain maturation of preterm infants. However, the effect of enlightenment on functional brain maturation of premature infants has not been investigated. We aimed to do this with aEEG.
Study Design A total of 32 infants, 30 to 35 gestational weeks, were involved in the study. They were randomly distributed into three groups in which different lighting protocols were applied. In group 1, the infants' incubators were covered for 24 hours. In group 2, the infants' incubators were open for 24 hours. In group 3, the infants' incubators were covered for 12 hours and open for another 12 hours. The infants are evaluated with aEEG recordings done on the 3rd (first measurement) and 10th days (second measurement) along with the Burdjalov scoring. Analysis of aEEG recordings was performed, based on sleep–wake cycles (SWCs), upper and lower margin amplitudes, narrowband and broadband of SWC, and bandwidth of SWC.
Results At first, the narrowband lower amplitudes in group 1 were higher than those of the other groups (p = 0.042), but the difference was not significant in the second measurement (p = 0.110). The Burdjalov scores were higher in group 1 and group 3 on 10th day, though not statistically significant (p = 0.871). When the infants were re-evaluated according to the gestational weeks, the Burdjalov scores of the two groups less than 34 weeks (30–31 and 32–33 weeks) were similar, whereas 34 to 35 weeks were higher when compared with those of the two groups.
Conclusion The difference observed between groups in terms of narrowband lower amplitude in the first measurement may reflect the effect of intrauterine environment rather than enlightenment at the same gestational age because it was made on the third day. However, the fact that all groups have similar results on day 10 suggests that other factors in the intensive care setting may diminish the effect of enlightenment. Burdjalov scores are associated with maturation, and high scores found in the 34- to 35-week group suggest that the 34-week maturation might be a threshold for SWC and development in our group sample.
Imaging of Tropical Chronic Pancreatitis—A Unique Clinico-Radiological Entity
Authors: Kulkarni Chinmay Bhimaji , Sekhar Resmi , Moorthy Srikanth , Pullara Sreekumar Karumathil , Prabhu Nirmal Kumar , Kannan Ramiah Rajesh 
Published: November 2019

AbstractTropical chronic pancreatitis (TCP) is a unique juvenile nonalcoholic form of chronic pancreatitis prevalent in tropical developing countries. TCP is characterized by the younger age of onset, rapid progression, higher prevalence of diabetes and pancreatic calculi, and greater propensity to develop pancreatic malignancy. Identifying the distinct imaging features is critical for the diagnosis of TCP. Awareness of this condition will not only enable the radiologist to recognize it early but also help in better management. In this article, we review the etiopathogenesis, distinct imaging features, and complications of TCP.
How Do We Treat Pregnancy-Related Venous Thromboembolism?
Authors: Linnemann Birgit , Seelbach-Goebel Birgit , Heimerl Susanne , Hart Christina 
Published: November 2019

AbstractVenous thromboembolism (VTE) is a major cause of maternal morbidity and mortality during pregnancy and the postpartum period. Due to a lack of adequate study data, therapeutic strategies for pregnancy-related VTE are deduced from observational studies and extrapolated from recommendations for nonpregnant patients. Because heparins do not cross the placenta, weight-adjusted therapeutic-dose low-molecular-weight heparins (LMWHs) are the anticoagulant treatment of choice in cases of VTE during pregnancy. Once- and twice-daily dosing regimens are suitable. There is no evidence that measurement of factor Xa activities and consecutive LMWH dose adjustments improve clinical outcomes. There is no support for the routine use of vitamin K antagonists, direct oral thrombin or factor Xa inhibitors, fondaparinux, or danaparoid in uncomplicated pregnancy-related VTE. Management of delivery deserves special attention, and treatment strategies depend on the time interval between the diagnosis of acute VTE and the expected delivery date. In lactating women, an overlapping switch from LMWH to warfarin is possible. Anticoagulation should be continued for at least 6 weeks postpartum or for a minimum period of 3 months.
Multispecialty Microsurgical Course Utilizing the Blue-Blood Chicken Thigh Model Significantly Improves Resident Comfort, Confidence, and Attitudes in Multiple Domains
Authors: Shulzhenko Nikita O. , Zeng Weifeng , Albano Nicholas J. , Lyon Sarah M. , Wieland Aaron M. , Mahajan Ashish Y. , Williams Daniel , Bentz Michael L. , Poore Samuel O. 
Published: November 2019

Abstract
Background The high level of technical skill required by microsurgical procedures has prompted the development of in vitro educational models. Current models are cost-ineffective, unrealistic, or carry ethical implications and are utilized as isolated experiences within single surgical specialties. The purpose of this study was to assess the educational and interprofessional effect of a microsurgical training course utilizing the nonliving “Blue-Blood” chicken thigh model (BBCTM) in a multidisciplinary environment.
Methods A 10-hour course was developed integrating didactic lectures, case presentations, and one-on-one practical sessions utilizing hydrogel microvessels and the BBCTM. Pre- and postcourse surveys were administered assessing participants' self-reported comfort and confidence within fundamental microsurgical domains, assessments of the models utilized, and the effects of a multidisciplinary environment on the experience.
Results A total of 19 residents attended the course on two separate occasions (n = 10 and n = 9, respectively). Respondents varied from postgraduate year-2 (PGY-2) to PGY-6+ and represented plastic and reconstructive surgery (n = 10), urology (n = 6), and otolaryngology (n = 3). On average, each participant performed 4.3 end-to-end, 1.3 end-to-side, and 0.4 coupler-assisted anastomoses. Following the course, participants felt significantly more comfortable operating a microscope and handling microsurgical instruments. They felt significantly more confident handling tissues, manipulating needles, microdissecting, performing end-to-end anastomoses, performing end-to-side anastomoses, using an anastomotic coupler, and declaring anastomoses suitable (all p < 0.05). The majority of participants believed that the use of live animals in the course would have minimally improved their learning. All but two respondents believed the course improved their awareness of the value of microsurgery in other specialties “very much” or “incredibly.”
Conclusion A microsurgical training course utilizing nonliving models such as the “BBCTM significantly improves resident comfort and confidence in core operative domains and offers an in vivo experience without the use of live animals. Multispecialty training experiences in microsurgery are beneficial, desired, and likely underutilized.
The Reliability of Classifying the Morphology of Anterior Cruciate Ligament Remnants during Surgery
Authors: Haviv Barak , Shemesh Shai , Kittani Mohamed , Yassin Mustafa , Yaari Lee 
Published: November 2019

AbstractArthroscopic classification of the torn anterior cruciate ligament (ACL) morphology is fundamental for clinical studies on emerging techniques such as repair and preservation. At present, the most acknowledged classification is Crain description of four morphological patterns. The purpose of the study was to analyze the intra- and interobserver reliability of Crain classification in patients undergoing ACL reconstruction surgeries. The study included 101 patients who had ACL reconstruction surgery between the years 2014 and 2017. The morphological pattern of ACL remnant scar formation during surgery was observed and classified according to Crain by three orthopaedic surgeons. Inter- and intraobserver reliabilities were measured using kappa statistics. Intraobserver reliability for the Crain classification ranged from 0.63 to 0.83 (substantial to almost perfect agreement). Interobserver reliability was 0.51 (moderate agreement). In almost a third of the cases, observers reported on additional morphological pattern of scar formation that was not well defined by Crain. A modified classification of four patterns was suggested: (A) without scar tissue, (B) with adhesion to the femoral notch (wall or roof), (C) with adhesion to the notch and posterior cruciate ligament (PCL), and (D) with adhesion to the PCL. Reanalysis of these four morphological configurations resulted in interobserver reliability of 0.82 (almost perfect agreement). In conclusion, the Crain classification of torn ACL remnant morphology has moderate interobserver reliability; however, a suggested classification with modified and additional configurations has almost perfect reliability and may be useful for studies on ACL repair and preservation.
Capabilities of GaN/AlN/GaN structures as high-intensity pyroelectric laser sensors
Authors: Panyutin E.A. , Shmatov M.L. 
Published: November 2019

Abstract
The use of transparent Al2O3/GaN/AlN/GaN structures as pyrometric sensors for measuring the parameters of high-intensity laser pulses is proposed. The peculiarities of the employment of such sensors in laser fusion facilities are analysed. Post-pulse distributions of the absorbed energy density are obtained for various parameters of both GaN layers. The local maxima of these distributions are minimised by varying the ratio of donor concentration and the ratio of their thicknesses under the condition of invariance of the total absorbed energy. The optimal structure configuration is established in terms of reducing the possible negative effect of laser impact on the pyroelectric coefficient stability.
Modelling an electro-optical modulator based on a vertical p – n junction in a silicon-on-insulator structure
Authors: Tsarev A.V. , Taziev R.M. 
Published: November 2019

Abstract
We report the results of numerical simulation of a Mach – Zehnder electro-optical modulator using beam splitters based on multimode interference in a silicon-on-insulator structure. The control is provided due to the depletion effect in the vertical p – n junction, which can be fabricated using the self-alignment technology. An optimal modulator design is proposed, which impedance is matched with an external 50-Ω load, for which, with a reverse bias of – 5 V and an active length of 1.7 mm, the optical frequency bandwidth of ∼ 50 GHz can be achieved. A special doping profile of the p – n junction of the modulator is presented, which provides an optical frequency bandwidth of 30 GHz with a reverse bias of –3 V and a modulator length of 2.5 mm. Such modulators can be used in integrated optics, optical communications and radio photonics devices.
Flat-field VLS spectrometer for a wavelength range of 50 – 275 Å
Authors: Kolesnikov A.O. , Vishnyakov E.A. , Shatokhin A.N. , Ragozin E.N. 
Published: November 2019

Abstract
A flat-field VLS spectrograph for a wavelength range ∼50 – 275 Å with an average linear dispersion of 0.18 mm Å−1, which makes use of a grazing-incidence varied line-space (VLS) grating, was calculated and implemented (a spectrograph of Harada class). To fabricate the VLS grating by interference lithography technique, an algorithm was developed for calculating the writing configuration with an auxiliary aberrating mirror (the solution of the inverse problem of interference lithography). The spectrograph was put to a test and line spectra were recorded from the laser-produced plasma of lithium fluoride and teflon targets, which were excited by a focused laser beam (0.5 J, 8 ns, 1.06 μm). A resolving power λ/d l = 800 was demonstrated in a wavelength region of 135 Å.
Physical processes affecting the survival of microbiological systems in laser printing of gel droplets
Authors: Zarubin V.P. , Zhigarkov V.S. , Yusupov V.I. , Karabutov A.A. 
Published: November 2019

Abstract
We consider laser printing of gel microdroplets – a promising method for microbiology, biotechnology and medicine. In the printing process, small volumes of gel containing living microorganisms are transferred as a result of cavitation caused by the absorption of a short laser pulse in a metal film. However, in such a transfer, certain physical factors arise that can lead to damage and death of biological material. These factors include elevated temperature and pressure, high radiation intensity and some others. Experimental estimates of these parameters are conducted, based on measurements of the acoustic response of laser printing, electron microscopy of the affected areas and the results of high-speed imaging of the transfer process. It is shown that these factors are not a significant limitation for the technology being developed. Laser printing is performed by exposing a metal film to laser pulses with an energy of 5 – 30 μJ and a duration of 8 – 14 ns, the laser beam diameter being 30 μm.
Extended high-frequency hearing enhances speech perception in noise
Authors: Motlagh Zadeh Lina , Silbert Noah H. , Sternasty Katherine , Swanepoel De Wet , Hunter Lisa L. , Moore David R. 
Published: November 2019

Significance
Understanding speech in noisy environments is an essential communication skill that varies widely between individuals and is poorly understood. We show here that extended high-frequency (EHF) hearing, beyond the currently tested range of clinical audiometry, contributes to speech perception in noise. EHF hearing loss is common in otherwise normally hearing young adults and predicts self-reported difficulty hearing speech in noise. The data suggest that EHF hearing is a long sought missing link between audiometry and speech perception and may be a sensitive predictor of age-related hearing loss much earlier in life when preventive measures can be effectively deployed.
MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM
Authors: Kodama Takahiro , Marian Teresa A. , Lee Hubert , Kodama Michiko , Li Jian , Parmacek Michael S. , Jenkins Nancy A. , Copeland Neal G. , Wei Zhubo 
Published: November 2019

Significance
Myocardin-related transcription factor B (MRTFB) is a candidate tumor-suppressor gene identified in transposon mutagenesis screens of the intestine, liver, and pancreas. Using a combination of cell-based assays, in vivo tumor xenograft assays, and Mrtfb knockout mice, we demonstrate that MRTFB is a mouse and human colorectal cancer (CRC) tumor-suppressor gene that functions in part by inhibiting cell invasion and migration. Using whole transcriptome RNA sequencing in Mrtfb-knockdown cells, we also identify several MRTFB downstream genes, including a known tumor suppressor, MCAM, and a candidate tumor suppressor, SPDL1. Finally, we show that MCAM and SPDL1 are also human CRC tumor-suppressor genes that act downstream of MRTFB to regulate CRC growth and survival.
Does reported speech influence listeners’ choice of perspective in the interpretation of spatial prepositions?
Authors: Bonnema Ariska I. , Hukker Vera , Hendriks Petra 
Published: November 2019

AbstractLinguistic cues can encourage adults to adopt an other-centric rather than an egocentric perspective. This study investigated whether the presence of direct speech compared to indirect speech influences listeners’ choice of perspective when interpreting the Dutch spatial prepositionsvoor‘in front of’ andachter‘behind’. Dutch adults and 10 to 12-year-old children were tested in a sentence-picture verification task. Contrary to expectations, we found no difference between direct and indirect speech (Study 1), nor did we find a difference between reported and non-reported speech (Study 2). Most adult listeners adopted the contrasting perspective of the speaker, irrespective of how the information about the reported speech was expressed. We did find a difference between adults and children: children adopted the other person’s perspective less often than adults did. Overall, the results suggest that the mere presence of a reported speaker already is a cue for taking this speaker’s perspective.
Demonstrative-reinforcer constructions and the syntactic role of deictic features
Authors: Terenghi Silvia 
Published: November 2019

AbstractIn this paper I take Romance demonstrative-reinforcer constructions as a way to test whether the deictic features encoded by demonstrative and locative forms are active in the syntax. From a descriptive point of view, I claim that demonstrative systems can be best accounted for by making reference to two binary deictic person features: [dem[±Author]] and [dem[±Participant]]. Then I show how these features combine in demonstrative-reinforcer constructions, providing a comprehensive overview of demonstrative-reinforcer constructions in Italo-Romance varieties. Finally, I argue that deictic person features are inactive in the syntax of demonstrative and locative forms: this is suggested by the shortcomings that Agree-based accounts face when dealing with demonstrative-reinforcer constructions. Therefore, I contend that the best analysis for such constructions is a non-core syntactical one, the relevant derivation point being either within the morphological component or at the interface between syntax and semantics.