bluuebunny/crossref_metadata_2025_split huggingface dataset:
BLSBA‐ED‐SSO: Bivariate Lévy‐stable bat algorithm‐based energy detection for spectrum sensing optimization in cognitive radio networks (CRNs)
Authors: Babu Senthil Kumar , Venkataramanan C. 
Published: January 2020

SummaryThe vacant licensed spectrum can be employed by the secondary users in cognitive radio networks. Nevertheless, this process of identification is frequently agreed with shadowing, multipath fading and receiver uncertainty problems. The primary contributions of the spectrum sensing techniques adopted in this work mainly concentrate on energy detection for spectrum sensing as well as to recognize the optimal spectral estimation according to the multitaper spectral estimation. The algorithm proposed in this work is based on bivariate Lévy‐stable bat algorithm (BLSBA), energy detector (ED), and with the help of K out of M fusion rule; it is analysed for the single user as well as cooperative multiple users. In the BLSBA algorithm, a modified search equation with more helpful information from the search experiences is brought‐in to create an optimal energy solution and bivariate Lévy‐stable random walk is associated with BLSBA to remove the trapping process into local optima. The energy detection is defined numerically from this optimal detection. At last, a multi‐taper spectral estimator (MSE) is proposed to cognitive radio detection for a huge network. The simulation results in both cases are computed and checked with the help of a BLSBA optimizer. For an individual secondary user scenario, the advancement of MSE to the ED is broadly described. Experimental result indicates that the objective false alarm likelihood is minimized and the demanded signal‐to‐noise ratio is accomplished to the extent.
Detection and quantitation of synthetic cannabinoid receptor agonists in infused papers from prisons in a constantly evolving illicit market
Authors: Norman Caitlyn , Walker Gillian , McKirdy Brian , McDonald Ciara , Fletcher Daniel , Antonides Lysbeth H. , Sutcliffe Oliver B. , Nic Daéid Niamh , McKenzie Craig 
Published: January 2020

AbstractDrug misuse in prisons contributes to increased disruption and violence and negatively impacts prisoner safety, rehabilitation, and recovery. Synthetic cannabinoid receptor agonists (SCRAs), colloquially known as “spice”, are infused into papers and are of particular concern in a prison setting where they are commonly vaped. Methods for the qualitative and quantitative analysis of SCRA infused papers, including impurity profiling, were developed using gas chromatography–mass spectrometry (GC–MS) with qualitative confirmation by ultra high pressure liquid chromatography with photodiode array and quadrupole time of flight mass spectrometry detection (UPLC‐PDA‐QToF‐MS) and applied to 354 individual seized paper samples originating from 168 seizures from three Scottish prisons. Of these samples, 41% (146 samples from 101 seizures) contained at least one SCRA and multiple SCRAs were detected on 23% of these papers. Concentrations ranged from < 0.05–1.17 mg/cm2 paper, representing the first reported quantitative data for SCRA infused papers. An evolution in the SCRAs detected was demonstrated; 5F‐MDMB‐PINACA (5F‐ADB) predominated until late 2018, after which time 5F‐MDMB‐PICA and 4F‐MDMB‐BINACA became increasingly more prevalent, followed by the arrival of MDMB‐4en‐PINACA in June 2019. Concentration mapping data from two seized paper samples demonstrated that SCRA concentrations across larger papers were highly variable (0.47–2.38 mg/cm2 paper) making consistent dosing by users, and representative sampling by laboratory analysts, difficult. Near real‐time qualitative and quantitative information on SCRAs circulating in prisons acts as an early warning system for SCRAs emerging on the wider illicit market, inform the methods used to detect them and limit supply, and provide information to support harm reduction measures.
CD5 blockade enhances ex vivo CD8+ T cell activation and tumour cell cytotoxicity
Authors: Alotaibi Faizah , Rytelewski Mateusz , Figueredo Rene , Zareardalan Ronak , Zhang Meng , Ferguson Peter J , Maleki Vareki Saman , Najajreh Yousef , El‐Hajjar Mikal , Zheng Xiufen , Min Wei‐ping , Koropatnick James 
Published: January 2020

AbstractCD5 is expressed on T cells and a subset of B cells (B1a). It can attenuate TCR signalling and impair CTL activation and is a therapeutic targetable tumour antigen expressed on leukemic T and B cells. However, the potential therapeutic effect of functionally blocking CD5 to increase T cell anti‐tumour activity against tumours (including solid tumours) has not been explored. CD5 knockout mice show increased anti‐tumour immunity: reducing CD5 on CTLs may be therapeutically beneficial to enhance the anti‐tumour response. Here, we show that ex vivo administration of a function‐blocking anti‐CD5 MAb to primary mouse CTLs of both tumour‐naïve mice and mice bearing murine 4T1 breast tumour homografts enhanced their capacity to respond to activation by treatment with anti‐CD3/anti‐CD28 MAbs or 4T1 tumour cell lysates. Furthermore, it enhanced TCR signalling (ERK activation) and increased markers of T cell activation, including proliferation, CD69 levels, IFN‐γ production, apoptosis and Fas receptor and Fas ligand levels. Finally, CD5 function‐blocking MAb treatment enhanced the capacity of CD8+ T cells to kill 4T1‐mouse tumour cells in an ex vivo assay. These data support the potential of blockade of CD5 function to enhance T cell‐mediated anti‐tumour immunity.
Oleogels Based on Palmitic Acid and Safflower Oil: Novel Formulations for Ocular Drug Delivery of Voriconazole
Authors: Mohanty Biswaranjan , Pal Kunal , Quereshi Dilshad , Nayak Suraj K. , Rathnam Vuppaladadium Shanmuga Sharan , Banerjee Indranil , Anis Arfat , Barik Chandra Sekhar , Sarkar Preetam , Rout Susanta Kumar 
Published: January 2020

AbstractThe gelation of the vegetable oils using fat crystals has gained significant attention in recent years. These formulations have been explored for food and pharmaceutical applications. The alteration in the properties of palmitic acid (20–40% w/w) and safflower oil oleogels is extensively studied at microscopic and macroscopic levels. The thermal and mechanical stability of the oleogels is improved when the proportion of the palmitic acid content is increased. However, under stress, the fat crystal network junction zones of the oleogels with higher proportions of palmitic acid undergo disruption. The changes in the properties of the oleogels are due to the alteration in the molecular packing, crystallite size, and lattice strain of the fat crystal network. The alteration in the properties is governed by the changes in the extent of inter‐ and intramolecular hydrogen bonding within the components of the oleogels. The oleogels can demonstrate the ability to deliver the drug, voriconazole, across the corneal tissue. Further, the prepared oleogels are biocompatible to murine fibroblast cells and do not elicit adverse reactions when instilled within the ocular sac of rabbits. The results suggest that the oleogels can be tried as ocular delivery vehicles.Practical Applications: The delivery of drug into the internal structure of the eye is a great challenge for the ophthalmologists. Usually no more than 1% of the drug can be delivered through conventional techniques. Various researchers have proposed the use of lipid‐based ocular drug delivery systems. Some of them include solid liquid nanoparticles, emulsions, and liposomes. However, the preparation of these formulations requires a tedious process. Keeping this in mind, it is proposed to synthesize oleogel as probable ocular drug delivery system.
On ion transport regulation with field‐effect nonlinear electroosmosis control in microfluidics embedding an ion‐selective medium
Authors: Liu Weiyu , Ren Yukun , Xue Rui , Song Chunlei , Wu Qisheng 
Published: January 2020

AbstractWe study herein numerically the use of induced‐charge electrokinetic phenomena to enable a flexible control of ion transport of dilute electrolyte in a straight ion concentration polarization system. The effect of three convection modes of induced‐charge electrokinetic phenomena, including induced‐charge electroosmosis, flow‐field effect transistor, and alternating‐current electroosmosis (ACEO), on convective arrestment of diffusive wave‐front propagation is investigated by developing a cross‐scale and fully coupled transient numerical simulation model, wherein multiple frequency electrochemical polarization and nonlinear diffuse charge dynamics in spatiotemporally varying solution conductivity are taken into account. We demonstrate by detailed comparative simulation studies that ACEO vortex flow field above a metal strip array arranged along the anodic chamber's bottom surface serves as the most efficient way for adjusting the salt density distribution at micrometer and even millimeter dimension, due to its high flexibility in controlling the stirring flow state with the introduction of two extra electrical parameters. The specific operating status is determined by whether the electrode array is floating in potential (induced‐charge electroosmosis) or biased to ground (flow‐field effect transistor) or forced to oscillate at another Fourier mode (ACEO). These results prove useful for on‐chip electric current control with electroconvective stirring.
Adaptive fuzzy Proportion Integration Differentiation control in hydraulic offshore wind turbine for optimal power extraction based on the estimated wind speed
Authors: Fan YaJun , Mu AnLe 
Published: January 2020

AbstractIn this paper, a novel fuzzy Proportion Integration Differentiation (PID) controller is proposed to extract the optimal energy from wind for a hydraulic offshore wind turbine. Firstly, in order to calculate the theoretical power, an adaptive neuro‐fuzzy inference system (ANFIS) is designed for wind speed evaluation, in which the input parameters include rotor speed, rotor torque, and pitch angle, and the output parameter is the estimated wind speed. Then, the optimal power coefficient is achieved by controlling the hydraulic pump torque to tracking the optimal rotor speed, and a fuzzy PID is designed to adjust the pump displacement and to obtain the optimal hydraulic pump torque. Furthermore, aiming to meet the various output power demand, a hydraulic accumulator is utilized for storing the excess energy, and a PID controller is designed for distributing the hydraulic energy between the accumulator and the Pelton turbine. Finally, the performance of proposed controls system are confirmed by two case simulations on a 5 MW hydraulic offshore wind turbine. The simulation results show that, compared with the conventional control methods (fuzzy logical and PID controller) used in electro‐hydraulic servo system, the fuzzy PID controller can provide the better tracking effect with a faster speed and a minimal steady‐state oscillation. Moreover, with the use of a hydraulic accumulator, all the power fluctuations from the wind speed disturbances are damped out and the output power become controllable.
Effect of non‐migrating bars on dune dynamics in a lowland river
Authors: de Ruijsscher T. V. , Naqshband S. , Hoitink A. J. F. 
Published: January 2020

AbstractAs dunes and larger‐scale bed forms such as bars coexist in rivers, the question arises whether dune dynamics are influenced by interaction with the underlying bed topography. The present study aims to establish the degree to which dune characteristics in two and three dimensions are influenced by an underlying topography dominated by non‐migrating bars. As a case study, a 20 km stretch in the Waal River in the Netherlands is selected, which represents a sand‐bed lowland river. At this location, longitudinal training dams (LTDs) have recently been constructed to ensure sufficient navigation depth during periods with low water levels, and to reduce flood risk. By using data covering 2‐year‐long periods before and after LTD construction, the robustness of the results is investigated. Before LTD construction, dune characteristics show large variability both spatially and temporally, with dunes being longer, lower, less steep and having a lower lee side angle when they are located on bar tops. The correlation between dune characteristics and the underlying bed topography is disrupted by unsteady conditions for which the dunes are in a state of transition. The bar pattern causes tilting of dune crest lines, which may result from a transverse gradient in bedload sediment transport. As a result of LTD construction, the hydraulic and morphological conditions have changed significantly. Despite this, the main conclusions still hold, which strengthens the validity of the results. ©2020 The Authors. Earth Surface Processes and Landforms published by John Wiley & Sons Ltd.
A generalized regression model based on hybrid empirical mode decomposition and support vector regression with back‐propagation neural network for mid‐short‐term load forecasting
Authors: Fan Guo‐Feng , Guo Yan‐Hui , Zheng Jia‐Mei , Hong Wei‐Chiang 
Published: January 2020

AbstractSince load forecasting plays a decisive role in the safe and stable operation of power systems, it is particularly important to explore forecasting methods accurately. In this article, the hybrid empirical mode decomposition (EMD) and support vector regression (SVR) with back‐propagation neural network (BPNN), namely the EMDHR‐SVR‐BPNN model, is proposed. Information theory is mainly used to solve the data tendency problem, and the EMD method is used to solve the data volatility problem. There is no interaction between these two methods; thus these two models can complement each other through generalized regression of orthogonal decomposition. Taking the load data from the New South Wales (NSW, Australia) market as an example, the obtained simulation results are compared with other models. It is concluded that the proposed EMDHR‐SVR‐BPNN model not only improves the forecasting accuracy but also has good fitting ability. It can reflect the changing tendency of data in a timely manner, providing a strong basis for the electricity generation of the power sector in the future, thus reducing electricity waste. The proposed EMDHR‐SVR‐BPNN model has potential for employment in mid‐short term load forecasting.
Timescale classification in wind forecasting: A review of the state‐of‐the‐art
Authors: Roungkvist Jannik Schütz , Enevoldsen Peter 
Published: January 2020

AbstractThe intermittency of the wind has been reported to present significant challenges to power and grid systems, which intensifies with increasing penetration levels. Accurate wind forecasting can mitigate these challenges and help in integrating more wind power into the grid. A range of studies have presented algorithms to forecast the wind in terms of wind speeds and wind power generation across different timescales. However, the classification of timescales varies significantly across the different studies (2010–2014). The timescale is important in specifying which methodology to use when, as well in uniting future research, data requirements, etc. This study proposes a generic statement on how to classify the timescales, and further presents different applications of these forecasts across the entire wind power value chain.
Antimicrobial activity of carboxymethyl cellulose–gelatin film containing Dianthus barbatus essential oil against aflatoxin‐producing molds
Authors: Mohammadi Mehrdad , Azizi Mohammad Hossein , Zoghi Alaleh 
Published: January 2020

AbstractEdible films, as novel degradable materials in food packaging, play an important role in removing consumers' concerns about environmental pollution and food contaminations. Carboxymethyl cellulose (CMC)–gelatin (G) edible films with the ratio 4 to 1 was selected as the optimal film based on physical, mechanical, and physicochemical findings. Then, the effects of 0, 300, 450, and 600 ppm Dianthus barbatus essential oil (DbE) on water vapor permeability, tensile strength, elongation at break, water solubility, glass transition temperature, color, oxygen permeability, and antimicrobial activities on the optimal film were investigated. CMC: G (4:1) containing 600 ppm DbE as the antibacterial–antioxidant film was the best formulae (p < .05) for preventing three types of aflatoxin‐producing mold including A. flavus (PTCC‐5004), A. parasiticus (PTCC‐5286), and A. parasiticus (PTCC‐5018) on pistachios for 6 months.
Investigation of the functional stability limits while squatting
Authors: Sugama Atsushi , Tonoike Yasuhiro , Seo Akihiko 
Published: January 2020

AbstractThis study investigates the functional stability limits (FSLs) in the squatting positions. Eleven male participants leaned and moved their pelvis horizontally in the clockwise and counter‐clockwise directions while squatting at 11 depth levels. The depth was controlled by changing the hip height from 100% to 0% of the upright position. The FSLs and the center of pressure excursion lengths were calculated from the force‐plate data, and the musculoskeletal loads on the lower limbs were estimated from the joint torques and surface electromyograms. As the hip height reduced, the area of the FSLs narrowed by up to 20% of the base of support (BOS) area at the deepest squatting position. The narrowing was affected by the decreasing FSLs in the forward direction, which also decreased by up to 20% of BOS. These quantitative data accurately evaluate the postural stability, suggesting a considerable fall risk during tasks requiring the squatting position.
The cross‐cultural moderators of the influence of emotional intelligence on organizational citizenship behavior and counterproductive work behavior
Authors: Miao Chao , Humphrey Ronald H. , Qian Shanshan 
Published: January 2020

AbstractThis meta‐analysis found that the emotional intelligence–organizational citizenship behavior relationship is stronger in long‐term oriented and restraint cultures. However, this relationship does not differ between individualistic and collectivistic cultures, masculine and feminine cultures, high uncertainty avoidance and low uncertainty avoidance cultures, and high power distance and low power distance cultures. The emotional intelligence–counterproductive work behavior relationship is stronger in collectivistic, feminine, high uncertainty avoidance, high power distance, long‐term oriented, and restraint cultures. Emotional intelligence–organizational citizenship behavior/counterproductive work behavior relationships are mediated by both state positive affect and state negative affect. Human resource development professionals from cultures where the effects of emotional intelligence are stronger are especially recommended to hire emotionally intelligent employees and/or provide emotional intelligence training to stimulate organizational citizenship behavior and to restrain counterproductive work behavior. Although there are important cross‐cultural differences, emotional intelligence universally encourages organizational citizenship behavior and almost universally diminishes counterproductive work behavior across cultures.
Preparation of aminoalkyl‐grafted bacterial cellulose membranes with improved antimicrobial properties for biomedical applications
Authors: He Wei , Zhang Zhaoyu , Zheng Yudong , Qiao Shen , Xie Yajie , Sun Yi , Qiao Kun , Feng Zhaoxuan , Wang Xiaoyang , Wang Jialong 
Published: January 2020

AbstractBacterial cellulose (BC) membranes display special properties and structures, thus attracting much attention in application in the biomedical areas, for example, as implants for bone or cartilage tissue engineering, as substitutes for skin repairing, and as supports for controlled drug delivery. However, native BC lacks the activity to inhibit bacteria growth on its surface, which limits its applications in biomedical fields. There have been reports on chemical modification of BC membranes to endow them with antimicrobial properties needed for some special biomedical applications. In the present study, aminoalkyl‐grafted BC membranes were prepared by alkoxysilane polycondensation using 3‐aminopropyltriethoxysilane (APTES). The characterization for morphology and chemical composition showed that BC membranes were successfully grafted with aminoalkylsilane groups through covalent bonding. The surface morphology and roughness of the membranes changed after chemical grafting. Furthermore, after grafting with APTES, the membranes got less hydrophilic than native BC. The aminoalkyl‐grafted BC membranes showed strong antibacterial properties against Staphylococcus aureus and Escherichia coli and moreover, they were nontoxic to normal human dermal fibroblasts. These results indicate that aminoalkyl‐grafted BC membranes are potential to be used for biomedical applications.
Emerging roles of HOTAIR in human cancer
Authors: Yuan Chunjue , Ning Yong , Pan Yunbao 
Published: January 2020

AbstractLong noncoding RNA HOX antisense intergenic RNA (HOTAIR) is overexpressed in many types of cancers, and substantial evidence has suggested a link between cancers and HOTAIR. In the present study, we reviewed the structure and the corresponding biologic function of HOTAIR to clarify its molecular mechanism in cancer progression. HOTAIR promotes proliferation, invasion, and migration, and inhibits apoptosis in cancer cells. HOTAIR also participates in the pathogenesis and progression of cancer by regulating inflammation and immune signaling. These findings suggested that HOTAIR is a novel biomarker in human cancers.
The inhibition profiles of 4'‐acylpyrrole–5‐fluoroindolin‐2‐ones with a C‐3' side chain for VEGFR2, PDGFR‐β, and FGFR‐1 protein kinases
Authors: Huang Jiann‐Jyh , Lin Yu‐Hsiang , Lai Chun‐Liang , Yang Sheng‐Chuan , Lin Shu Fu , Yang Ju‐Ying , Huang Hung‐Jyun , Liu Chiawei , Wei Win‐Yin , Chuang Shih‐Hsien , Chiang Chao‐Cheng , Lee Ying‐Shuen E. , Liao Chu‐Bin , Chern Ching Yuh 
Published: January 2020

AbstractIn this study, we reported the inhibition profiles of 4′‐acylpyrrole–5‐fluoroindolin‐2‐one 3 with a C‐3′ side chain for VEGFR2, PDGFR‐β, and FGFR‐1 protein kinases. The pyrrole‐fused cyclohexanone moiety provided 3 with the best potency to inhibit the three kinases, and the C‐3′ side chains contributed to the different inhibition profiles of 3. Compound 3b with a C‐3′ 2‐carboxylethyl side chain showed good potency for the three kinase (IC50: 25–260 nM), and compound 3g with a N,N‐dialkyl‐2‐carbamoylethyl side chain was more active for VEGFR2 (IC50: 59 nM) and PDGFR‐β (IC50: 16 nM) than FGFR‐1 (IC50: 1.7 μM). The C‐3′ 3‐(dialkylamino)propyl side chain accomplished 3h–j as selective PDGFR‐β inhibitors (IC50: 7.8–13 nM). Compound 3b was further investigated and found potent to inhibit VEGF‐ and FGF‐dependent cell proliferation with moderate in vivo anticancer activity. Results from docking simulations revealed that the interactions of 3b with VEGFR2 and FGFR‐1 which could account for the different inhibition profiles of 3.