bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevations of serum cancer biomarkers correlate with severity of COVID‐19
Authors: Wei Xiuqi , Su Jingyu , Yang Kunyu , Wei Jiazhou , Wan Huimin , Cao Xiaoling , Tan Wenbin , Wang Hui 
Published: April 2020

AbstractIn this retrospective study, we evaluated the levels of a series of serum biomarkers in coronavirus disease 2019 (COVID‐19) patients (mild: 131; severe: 98; critical: 23). We found that there were significant increases in levels of human epididymis protein 4 (HE4) (73.6 ± 38.3 vs 46.5 ± 14.7 pmol/L; P < .001), cytokeratin‐19 fragment (CYFRA21‐1) (2.2 ± 0.9 vs 1.9 ± 0.8 μg/L; P < .001), carcinoembryonic antigen (CEA) (3.4 ± 2.2 vs 2.1 ± 1.2 μg/L; P < .001), carbohydrate antigens (CA) 125 (18.1 ± 13.5 vs 10.5 ± 4.6 μg/L; P < .001), and 153 (14.4 ± 8.9 vs 10.1 ± 4.4 μg/L; P < .001) in COVID‐19 mild cases as compared to normal control subjects; their levels showed continuous and significant increases in severe and critical cases (HE4, CYFRA21‐1, and CA125: P < .001; CEA and CA153: P < .01). Squamous cell carcinoma antigen (SCC) and CA199 increased significantly only in critical cases of COVID‐19 as compared with mild and severe cases and normal controls (P < .01). There were positive associations between levels of C‐reactive protein and levels of HE4 (R = .631; P < .001), CYFRA21‐1 (R = .431; P < .001), CEA (R = .316; P < .001), SCC (R = .351; P < .001), CA153 (R = .359; P < .001) and CA125 (R = .223; P = .031). We concluded that elevations of serum cancer biomarkers positively correlated with the pathological progressions of COVID‐19, demonstrating diffuse and acute pathophysiological injuries in COVID‐19.
Future changes in Aridity Index at two and four degrees of global warming above preindustrial levels
Authors: Wang Xiaoxin , Jiang Dabang , Lang Xianmei 
Published: April 2020

AbstractIn this study, we project the global terrestrial changes in Aridity Index (AI), as defined by the ratio of annual precipitation to potential evapotranspiration (PET), at 2 and 4°C levels of global warming above the preindustrial conditions based on the outputs from 21 Coupled Model Intercomparison Project Phase 5 models under the Representative Concentration Pathways 8.5 (RCP8.5) scenario. Compared to the preindustrial period, the global terrestrial annual precipitation will increase by an average of 0.02% (3%), the annual PET will increase by 6% (15%) and AI will decrease by 0.1 (0.2) at the 2°C (4°C) warming level. More remarkable decreases in the annual AI are seen in the northern high latitudes, where will also experience greater increases in PET and precipitation. In general, the seasonal changes in AI display a similar spatial pattern to the annual changes and are characterized by the greatest decrease in December–January–February and the smallest in June–July–August. The largest expansion of drylands occurs in semi‐arid regions, followed by the expansion of arid regions, with area changes of 4% (7%) and 3% (4%) under the 2°C (4°C) scenario, respectively. Further analyses indicate that the AI changes are determined by PET in the northern high latitudes, and the contribution of PET to AI increases from the 2 to 4°C warming levels. Furthermore, changes in thermodynamic factors contribute most to the PET, and at a higher level of global warming, the contribution of thermodynamic factors increases and that of dynamic factors decreases.
Sugar Surfactant‐Based Shampoos
Authors: Nunes Andreia , Marques Paula , Marto Joana , Ascenso Andreia , Gonçalves Lídia , Fitas Manuel , Pinto Pedro , Sotomayor João , Ribeiro Helena M. 
Published: April 2020

AbstractNaturally derived surfactants in hair care products are a trend in cosmetic technology. This study aimed to formulate and fully characterize the performance of shampoos with sugar‐derived surfactants, namely, the alkyl polyglucosides decyl glucoside and coco‐glucoside. In addition, different thickeners and conditioning ingredients were added to improve the formulation properties. A sodium laureth sulfate (SLES) formulation was used as control. Rheology, pH, foaming, contact angles on a keratin surface, and surface tensions were determined. The safety of the formulations was evaluated by in vitro cytotoxicity studies using the human keratinocyte HaCaT cell line and human retinal pigment epithelial cells ARPE‐19. The efficacies were studied by in vitro hair combing force assays and in vivo sensorial analysis. The formulated sugar surfactant‐based shampoos showed the following properties: (i) pH values higher than those of SLES (which were posteriorly lowered with lactic acid); (ii) higher foamability than SLES, and high wettability; (iii) Newtonian behavior and predominance of liquid state with a suitable viscosity; (iv) low cytotoxicity in both human keratinocytes and retinal cell lines (in contrast to SLES); (v) easier hair combing than SLES, when Polyquaternium‐7 was used as conditioner; (vi) efficient and gentle hair washing; and (vii) favorable sensorial analysis confirming the previous washing properties. In conclusion, the sugar surfactants had a considerable impact in the properties of the shampoo formulations, in terms of both hair cleansing properties and efficacy, as demonstrated here. These favorable outcomes clearly support the use of these ingredients in shampoo formulation design.
Development of 55‐in. 8K AMOLED TV based on coplanar oxide thin‐film transistors and inkjet printing process
Authors: Wu Zhongyuan , Yan Liangchen , Li Yongqian , Feng Xuehuan , Shih Huaiting , Kim Taejin , Peng Yuqing , Yu Jianwei , Dong Xue 
Published: April 2020

AbstractIn this paper, we presented 55‐in. 8K4K AMOLED TV employing coplanar oxide thin‐film transistor (TFT) backplane, top emissive inkjet‐printing organic light‐emitting diode (OLED) device, gate driver on array (GOA), and compensation technologies. It is so far the largest prototype AMOLED TV fabricated by using inkjet printing process with 8K resolution. It shows the stunning display quality, thanks to the high resolution and fast refresh frequency. It proves that the inkjet printing process is not only cost competitive but also can deliver premium display.
Predictors of lymph node metastases in patients with mucinous appendiceal adenocarcinoma
Authors: Shannon Adrienne B. , Goldberg Drew , Song Yun , Paulson Emily C. , Roses Robert E. , Fraker Douglas L. , Kelz Rachel R. , Miura John , Karakousis Giorgos C. 
Published: April 2020

AbstractBackgroundLymph node metastasis (LN+) is a prognostic factor in appendiceal cancers, but predictors and outcomes for LN+  in mucinous appendiceal adenocarcinoma (MAC) remain poorly defined.MethodsPatients were identified from the 2010 to 2016 NCDB who underwent surgical resection as first‐line management for Stage I‐III mucinous appendiceal cancer. A LN+ risk‐score model was developed using multivariable regression on a training data set and internally validated using a testing data set. Three‐year overall survival (OS) was analyzed by Cox proportional hazards regression.ResultsOf 1158 patients, LN+ (N = 244, 21.1%) patients were more likely to have higher pT group and grade of disease, lymphovascular invasion (LVI), and positive margins on univariate analyses. Predictive factors associated with LN+ on multivariable analysis included positive surgical margins (odds ratio [OR] 3.00, P <.0001), higher grade (moderately differentiated: OR, 2.16, P < .0001; poorly or undifferentiated: OR, 3.07, P < .0001), and LVI (OR, 7.28, P < .0001). A validated risk‐score model using these factors was developed with good performance (AUC 0.749). LN+ patients had a worse 3‐year OS compared with LN− patients (17.4% vs 82.6%, hazard ratio 1.96, P = .001).ConclusionsLN+ is associated with worse survival in patients with MAC. A risk‐score model using margin status, LVI, and grade can accurately risk stratify patients for LN+.
Identifying active resident hosts of VFR visitors
Authors: Griffin Tom , Guttentag Daniel 
Published: April 2020

AbstractSubstantial tourism activity can be attributed to visiting friends and relatives travel. However, the identification and classification of hosts who are most active, participating in touristic attractions and culture, has received limited attention. This study surveyed residents of Toronto, Canada, and segmented them depending on their own activity while hosting. Findings show that highly active hosts are more likely to be immigrants, to be entertaining large groups of both friends and relatives, and to be hosting overseas visitors in the destination for the first time. The results have implications relating to the engagement of residents as destination ambassadors.
Measuring the size of the informal tourism economy in Thailand
Authors: Çakmak Erdinç , Çenesiz M. Alper 
Published: April 2020

AbstractThis study is the first to estimate the size of the informal tourism economy. Using a dynamic general equilibrium model, this paper first estimates the size of the informal tourism economy and then assesses its linkages to key labour market variables in Thailand. Empirical results indicate that: (a) the informal tourism economy grows faster than the formal tourism and aggregate economy; (b) both formal and informal tourism economies absorb the unemployed; (c) the relationship between formal and informal economies is negative in the aggregate but positive in the tourism sector.
Preparation of Methacrylate Polymer/Reduced Graphene Oxide Nanocomposite Particles Stabilized by Poly(ionic liquid) Block Copolymer via Miniemulsion Polymerization
Authors: Yamane Mitsuyoshi , Fadil Yasemin , Tokuda Masayoshi , Zetterlund Per B. , Minami Hideto 
Published: April 2020

AbstractPoly(n‐butyl methacrylate) (PnBMA)/reduced graphene oxide (rGO) nanocomposite films are prepared using two different routes. The first route involves preparation of PnBMA nanoparticles containing homogeneously dispersed rGO nanosheets by miniemulsion polymerization using a block copolymer of ionic liquid (IL) monomer and nBMA. The IL units act as adsorption sites for rGO whereas BMA units provide solubility in the BMA monomer droplets. Nanocomposite films obtained from miniemulsion polymerization exhibit higher tensile modulus in comparison with the films prepared by mixing a PnBMA emulsion and aqueous graphene oxide (GO) dispersion. The second route involves preparation of PnBMA particles armored with rGO nanosheets via miniemulsion polymerization using the same poly(ionic liquid) (PIL) block copolymer. An anionic exchange reaction is conducted to obtain more hydrophilic PIL units in the block copolymer, thus providing adsorption sites of GO nanosheets at the interface of the polymer particles. Subsequent chemical reduction of GO to rGO using hydrazine monohydrate results in formation of a PnBMA/rGO nanocomposite. The resulting nanocomposite film exhibits electrical conductivity (2.0 × 10−3 S m−1).
Kinesin family member 11 is a potential therapeutic target and is suppressed by microRNA‐30a in breast cancer
Authors: Wang Benfang , Yu Jianjiang , Sun Zhenjiang , Luh Frank , Lin Dandan , Shen Ying , Wang Ting , Zhang Qi , Liu Xiyong 
Published: April 2020

AbstractKinesin family member 11 (KIF11) is a plus end‐directed kinesin indispensable for the formation of the bipolar spindle in metaphase, where it objects to the action of minus end‐directed molecular motors. Here, we hypothesize that KIF11 might be a therapeutic target of breast cancer and regulated by miR‐30a. Cell Counting Kit 8 assays were used to investigate cell proliferation. Invasion assays were used to survey the motility of cells. Kaplan‐Meier and Cox proportional analyses were employed for this outcome study. The prognostic significance and performance of KIF11 were validated on 17 worldwide independent microarray datasets and two The Cancer Genome Atlas‐Breast Invasive Carcinoma sets. microRNA was predicted targeting KIF11 through sequence alignment in microRNA.org and confirmed by coexpression analysis in human breast cancer samples. Dual‐luciferase reporter assays were employed to validate the interaction between miR‐30a and KIF11 further. Higher KIF11 mRNA levels and lower miR‐30a were significantly associated with poor survival of breast cancer patients. Inhibition of KIF11 by small‐hairpin RNA significantly reduced the proliferation and invasion capabilities of the breast cancer cells. Meanwhile, downregulation of KIF11 could enhance the cytotoxicity of adriamycin in breast cancer cell lines MCF‐7 and MDA‐MB‐231. A population study also validated that chemotherapy and radiotherapy significantly improved survival in early‐stage breast cancer patients with low KIF11 expression levels. Further bioinformatics analysis demonstrated that miR‐30a could interact with KIF11 and validated by dual‐luciferase reporter assays. Therefore, KIF11 is a potential therapeutic target of breast cancer. miR‐30a could specifically interact with KIF11 and suppress its expression in breast cancer.
Mitochondrial Complex 1, Sigma 1, and Synaptic Vesicle 2A in Early Drug‐Naive Parkinson's Disease
Authors: Wilson Heather , Pagano Gennaro , de Natale Edoardo Rosario , Mansur Ayla , Caminiti Silvia Paola , Polychronis Sotirios , Middleton Lefkos T. , Price Geraint , Schmidt Karl F. , Gunn Roger N. , Rabiner Eugenii A. , Politis Marios 
Published: April 2020

AbstractBackgroundDysfunction of mitochondrial energy generation may contribute to neurodegeneration, leading to synaptic loss in Parkinson's disease (PD). The objective of this study was to find cross‐sectional and longitudinal changes in PET markers of synaptic vesicle protein 2A, sigma 1 receptor, and mitochondrial complex 1 in drug‐naive PD patients.MethodsTwelve early drug‐naive PD patients and 16 healthy controls underwent a 3‐Tesla MRI and PET imaging to quantify volume of distribution of [11C]UCB‐J, [11C]SA‐4503, and [18F]BCPP‐EF for synaptic vesicle protein 2A, sigma 1 receptor, and mitochondrial complex 1, respectively. Nine PD patients completed approximately 1‐year follow‐up assessments.ResultsReduced [11C]UCB‐J volume of distribution in the caudate, putamen, thalamus, brain stem, and dorsal raphe and across cortical regions was observed in drug‐naive PD patients compared with healthy controls. [11C]UCB‐J volume of distribution was reduced in the locus coeruleus and substantia nigra but did not reach statistical significance. No significant differences were found in [11C]SA‐4503 and [18F]BCPP‐EF volume of distribution in PD compared with healthy controls. Lower brain stem [11C]UCB‐J volume of distribution correlated with Movement Disorder Society Unified Parkinson's Disease Rating Scale part III and total scores. No significant longitudinal changes were identified in PD patients at follow‐up compared with baseline.ConclusionsOur findings represent the first in vivo evidence of mitochondrial, endoplasmic reticulum, and synaptic dysfunction in drug‐naive PD patients. Synaptic dysfunction likely occurs early in disease pathophysiology and has relevance to symptomatology. Mitochondrial complex 1 and sigma 1 receptor pathology warrants further investigations in PD. Studies in larger cohorts with longer follow‐up will determine the validity of these PET markers to track disease progression. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Characterization of free space optical data center channel
Authors: Darwesh Laialy , Arnon Shlomi , Kopeika Natan 
Published: April 2020

AbstractThe existing wired intra data center (DC) networks suffer from traffic congestion, low scalability, low flexibility, and increasing power consumption. To solve this problem there is a need to move from wired to wireless intra DC connections. One of the technologies that could provide a solution for the next generation intra DC communication is the use of free space optical (FSO) communication. However, in DC networks there is turbulence that can affect performance of FSO communication. In this letter, we present a DC experiment that we performed to characterize the performance of the FSO intra DC turbulent channel. We found that the pdf of the received signal is lognormally distributed according to the theoretical predictions, and we received values of bit error rate less than 10−16 in all the areas of the DC, which is better than the desired minimum of 10−14 for DC communication. This means that the realization of FSO communication within a turbulence channel DC is possible with good performance. If the turbulence is strong, we can improve the performance by using different mitigation techniques or by using hybrid wired and FSO connections.
Investigating the impact of alpha/beta and LETd on relative biological effectiveness in scanned proton beams: An in vitro study based on human cell lines
Authors: Mara Elisabeth , Clausen Monika , Khachonkham Suphalak , Deycmar Simon , Pessy Clara , Dörr Wolfgang , Kuess Peter , Georg Dietmar , Gruber Sylvia 
Published: April 2020

PurposeA relative biological effectiveness (RBE) of 1.1 is commonly used in clinical proton therapy, irrespective of tissue type and depth. This in vitro study was conducted to quantify the RBE of scanned protons as a function of the dose‐averaged linear energy transfer (LETd) and the sensitivity factor (α/ß)X. Additionally, three phenomenological models (McNamara, Rørvik, and Jones) and one mechanistic model (repair‐misrepair‐fixation, RMF) were applied to the experimentally derived data.MethodsFour human cell lines (FaDu, HaCat, Du145, SKMel) with differential (α/ß)X ratios were irradiated in a custom‐designed irradiation setup with doses between 0 and 6 Gy at proximal, central, and distal positions of a 80 mm spread‐out Bragg peak (SOBP) centered at 80 mm (setup A: proton energies 66.5–135.6 MeV) and 155 mm (setup B: proton energies 127.2–185.9 MeV) depth, respectively. LETd values at the respective cell positions were derived from Monte Carlo simulations performed with the treatment planning system (TPS, RayStation). Dosimetric measurements were conducted to verify dose homogeneity and dose delivery accuracy. RBE values were derived for doses that resulted in 90 % (RBE90) and 10 % (RBE10) of cell survival, and survival after a 0.5 Gy dose (RBE0.5Gy), 2 Gy dose (RBE2Gy), and 6 Gy dose (RBE6Gy).ResultsLETd values at sample positions were 1.9, 2.1, 2.5, 2.8, 4.1, and 4.5 keV/µm. For the cell lines with high (α/ß)X ratios (FaDu, HaCat), the LETd did not impact on the RBE. For low (α/ß)X cell lines (Du145, SKMel), LQ‐derived survival curves indicated a clear correlation of LETd and RBE. RBE90 values up to 2.9 and RBE10 values between 1.4 and 1.8 were obtained. Model‐derived RBE predictions slightly overestimated the RBE for the high (α/ß)X cell lines, although all models except the Jones model provided RBE values within the experimental uncertainty. For low (α/ß)X cell lines, no agreement was found between experiments and model predictions, that is, all models underestimated the measured RBE.ConclusionsThe sensitivity parameter (α/ß)X was observed to be a major influencing factor for the RBE of protons and its sensitivity toward LETd changes. RBE prediction models are applicable for high (α/ß)X cell lines but do not estimate RBE values with sufficient accuracy in low (α/ß)X cell lines.
Diffusion tensor magnetic resonance imaging of the postoperative spine with metallic implants
Authors: Yang Lian , Liu Yuan , Kong Xiangchuang , Guo Xiaodong , Liu Xiaoming , Qi Qian , Wang Jiazheng 
Published: April 2020

AbstractThere has been a growing need to understand the mechanism of development of acute spinal cord injury (SCI) and to optimize treatment. The paramagnetic nature of metallic implants has hampered the application of diffusion tensor imaging (DTI) in postsurgical SCI monitoring. We describe here a successful implementation of spinal DTI in postsurgical SCI patients. Data were acquired using a single‐shot turbo‐spin‐echo sequence, where an extra gradient is applied before the refocusing pulse train to eliminate contributions from the non‐Carr‐Purcell‐Meiboom‐Gill components following a diffusion preparation block where a single‐spin echo scheme is deployed. The DTI images were acquired in axial orientation with a 2 x 2 x 4 mm3 resolution and a total of 18 slices. Diffusion gradients were applied in six directions with b values of 0 and 600 seconds/mm2. The whole scan took ~10 minutes. The sequence was compared with SENSE‐DW‐EPI and ZOOM‐DW‐EPI on a phantom, eight patients with either anterior or posterior titanium alloy implants, and a pork loin with a similar implant. The protocol resulted in dramatically reduced geometric distortions compared with routine imaging sequences, however, the SNR efficiency was compromised. The spinal cord signal displacement was 0.68±1.00 mm (mean±SD, n = 8) for the proposed protocol, and 5.14±3.07 and 2.82±1.60 mm for the SENSE‐DW‐EPI and ZOOM‐DW‐EPI sequences, respectively. Fiber tracking was achieved in the presence of implants, which in one case was accompanied by central spinal cord caviation. Mathematical analysis concluded that the proposed protocol would be generally applicable in the spinal cord when the titanium alloy implant is ~15 mm away (<0.5 kHz B0 field drift). The protocol described is capable of DTI in postsurgery SCI patients with metallic implants at sufficient resolution and SNR.
Effect of Sleeve Gastrectomy on Kisspeptin Expression in the Hypothalamus of Rats with Polycystic Ovary Syndrome
Authors: Wen Lingying , Lin Wei , Li Qian , Chen Gang , Wen Junping 
Published: April 2020

ObjectivesThe purpose of this study was to determine changes in the expression levels of kisspeptin‐1 (Kiss1) in the hypothalamus during the development of polycystic ovary syndrome (PCOS) and after treatment with sleeve gastrectomy (SG).MethodsThis study used chronic dehydroepiandrosterone (DHEA) alone and DHEA plus a high‐fat diet (HFD) to generate a PCOS rat model. Subsequently, SG was performed in the animals with PCOS and the effects on glucose tolerance, insulin sensitivity, sex hormones, estrous cyclicity, adiponectin, and Kiss1 expression in the hypothalamus were investigated.ResultsImpaired glucose tolerance, decreased insulin sensitivity, reduced adiponectin levels, disrupted estrous cyclicity, and elevated sex hormone levels associated with PCOS models were restored to normal following SG. In addition, SG was able to restore the increase in the expression of Kiss1 mRNA and Kiss1‐positive neurons in the arcuate nucleus of rats with PCOS. Interestingly, although SG did not result in a significant loss of body weight in rats administered DHEA under a chow diet, it resulted in comparable metabolic improvements and Kiss1 expression in rats that had been administered DHEA along with an HFD.ConclusionsThe recovery of normal levels of Kiss1 expression in the hypothalamus after SG in this study suggests that Kiss1 might play an important role in the development of PCOS and its improvement by SG.
Recent Advances in Pathology: the 2020 Annual Review Issue of The Journal of Pathology
Authors: Herrington C Simon , Poulsom Richard , Coates Philip J 
Published: April 2020

AbstractThis year's Annual Review Issue of The Journal of Pathology contains 18 invited reviews on current research areas in pathology. The subject areas reflect the broad range of topics covered by the journal and this year encompass the development and application of software in digital histopathology, implementation of biomarkers in pathology practice; genetics and epigenetics, and stromal influences in disease. The reviews are authored by experts in their field and provide comprehensive updates in the chosen areas, in which there has been considerable recent progress in our understanding of disease. © 2020 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.