bluuebunny/crossref_metadata_2025_split huggingface dataset:
The experience of women following first acute coronary syndrome: An integrative literature review
Authors: Alyasin Najmeh , Teate Alison , Strickland Karen 
Published: January 2021

AbstractAimThere is lack of evidence and research understanding among women's lived experiences following first acute coronary syndrome, thus their recovery process remains poorly understood. To date research has largely focused on men's experience of acute coronary syndrome while this area of health care and recovery has considerable impact on women's health and quality of life. Our aim was to review the literature exploring lived experience of women following first acute coronary syndrome.DesignIntegrative review of the literature.Data sourceWe searched PubMed, MEDLINE, EMBASE, CINAHL and Scopus from 2008–2018 for articles published in English.Review methodOf 1675 publications identified, 18 qualitative, quantitative, and mixed method studies met our inclusion criteria. Quality of included studies was assessed using Joanna Briggs Institute quality assessment tools. Findings were integrated using thematic synthesis.ResultsExperiencing acute coronary syndrome was reported to have significant impacts on women's lives. The most common issues reported were physical limitations, fear, and uncertainties about the future, sexual dissatisfaction, and social isolation. Women also reported to have higher short‐ and long‐term mortality rate, stroke, recurrent, and hospital readmissions compared with men.ConclusionThis review identified current knowledge and gaps about lived experience of women following first acute coronary syndrome. It is anticipated that the information gained from this literature review will support new research aimed at improving the care women receive following acute coronary syndrome and therefore enhance their recovery and quality of life.ImpactThis review contributes to the current body of knowledge by addressing women's physical, psychosocial, and sexual state following acute coronary syndrome. Improvement in women's quality of life after acute coronary syndrome necessitates further research which ultimately results in better management and treatment of women and their recovery following first acute coronary syndrome.
Serum angiopoietin‐2 level as a novel potential biomarker in oral lichen planus
Authors: Bessar Hagar , Hammad Noha M. , Ismail Tawhed , Teama Mohamed AbdElkader , Youssef Ayman 
Published: January 2021

AbstractBackgroundLichen planus is a common chronic cutaneous inflammatory disease. Recent advances evidenced that angiogenesis is tightly connected to it. More recently, the endothelial specific growth factor angiopoietin‐2 has been clarified to interact with vascular endothelial growth factor. Angiopoietin‐2 level has not been investigated in lichen planus.AimTo evaluate serum level of angiopoietin‐2 in cutaneous and oral lichen planus.MethodsNinety patients were investigated, 45 patients with lichen planus. In addition to forty‐five healthy control, the activity of the disease was estimated at the time of examination. The serum level of angiopoietin‐2 had been estimated by enzyme‐linked immunosorbent assay. The relationships between angiopoietin‐2 serum level and disease severity, type of lichen, and visual analogue scale score (VAS) were determined.ResultsThe serum levels of angiopoietin‐2 were substantially higher in patients with both cutaneous and oral lesions than patients with cutaneous lichen planus only (P < .001).ConclusionsSerum angiopoietin‐2 is elevated in patients compared with normal subjects and is correlated with the presence of oral lesions and disease severity, that reflects its role in angiogenesis and inflammation, and angiopoietin‐2 serum level could be a potential marker for monitoring the oral lichen to identify possible malignant transformation.
Facilitating business model innovation: The influence of sustainability and the mediating role of strategic orientations
Authors: Klein Sascha P. , Spieth Patrick , Heidenreich Sven 
Published: January 2021

AbstractBusinesses increasingly incorporate the sustainability aspects into their products, services, and processes that drive innovation. While extant research on the linkage between sustainability and innovation has gained momentum over the past years, prior research has predominantly focused on sustainability's performance impacts (e.g., financially and environmentally) and product innovation outputs, neglecting the internal mechanisms that leverage sustainability. While findings from previous studies suggest that sustainability may drive business model innovation (BMI), it still lacks empirical evidence on whether and how sustainability may influence the evolvement of BMI. Relying on the stimulus‐organism‐response framework, we address these shortcomings and argue that sustainability commitment influences certain strategic orientations that increase the propensity of innovating a business model (BM). Using a sample of 167 German manufacturing firms, we empirically investigate these relationships. Our results from structural equation modeling show that the sustainability commitment has no direct effect on BMIs. Our mediation analysis does, however, reveal that sustainability commitment has complex indirect effects driving BMI through strategic orientations, namely the firm's market, technology, and entrepreneurial orientation. By uncovering the mechanisms through which sustainability commitment drives BMI, our findings provide new impetus on BMI’s internal drivers and highlight the important role of certain strategic behaviors that guide managers’ strategic choices when planning to innovate a BM. From a managerial perspective, our findings thus provide mangers with guidelines to achieve the right configuration of strategic orientations when responding to sustainability issues by innovating their current BM.
Comparison of silhouette‐based reallocation methods for vegetation classification
Authors: Lengyel Attila , Roberts David W. , Botta‐Dukát Zoltán 
Published: January 2021

AbstractAimsVegetation classification seeks to partition the variability of vegetation into relatively homogeneous but distinct types. There are many ways to evaluate, and potentially improve, such a partitioning. One effective approach involves calculating silhouette widths which measure the goodness‐of‐fit of plots to their cluster. We introduce a new iterative reallocation clustering method — Reallocation of Misclassified Objects based on Silhouette width (REMOS) — and compare its performance with an existing algorithm — OPTimizing SILhouette widths (OPTSIL). REMOS reallocates misclassified objects to their nearest‐neighbour cluster iteratively. Of its two variants, REMOS1 reallocates only the object with the lowest silhouette width, while REMOS2 reallocates all objects with negative silhouette width in each iteration. We test how REMOS1, REMOS2 and OPTSIL perform in terms of: (a) cluster homogeneity and separation; (b) the number of diagnostic species; and (c) runtime.MethodsWe classified simulated data with the flexible‐beta algorithm for values of beta from −1 to 0. These classifications were subsequently optimized by REMOS1, REMOS2 and OPTSIL and compared for mean silhouette widths, misclassification rate, and runtime. We classified three vegetation data sets from two to ten clusters, optimized all outcomes with the three reallocation methods, and compared their mean silhouette widths, misclassification rate, and number of diagnostic species.ResultsOPTSIL achieved the highest mean silhouette width across the majority of the data sets. REMOS achieved zero or negligible misclassifications, outperforming OPTSIL on this criterion. REMOS algorithms were typically more than an order of magnitude faster to calculate than OPTSIL. There was no clear difference between REMOS and OPTSIL in the number of diagnostic species.ConclusionsREMOS algorithms may be preferable to OPTSIL when: (a) the primary objective is to reduce the number of negative silhouette widths in a classification, as opposed to maximizing mean silhouette width; or (b) when the time efficiency of the algorithm is important.
Novel autophagic vacuolar myopathies: Phenotype and genotype features
Authors: Napolitano Filomena , Terracciano Chiara , Bruno Giorgia , De Blasiis Paolo , Lombardi Luca , Gialluisi Alessandro , Gianfrancesco Fernando , De Giovanni Donatella , Tummolo Albina , Di Iorio Giuseppe , Limongelli Giuseppe , Esposito Teresa , Melone Mariarosa Anna Beatrice , Sampaolo Simone 
Published: January 2021

AbstractBackgroundAutophagic vacuolar myopathies (AVMs) are an emerging group of heterogeneous myopathies sharing histopathological features on muscle pathology, in which autophagic vacuoles are the pathognomonic morphologic hallmarks. Glycogen storage disease type II (GSDII) caused by lysosomal acid α‐glucosidase (GAA) deficiency is the best‐characterised AVM.AimsThis study aimed to investigate the mutational profiling of seven neuromuscular outpatients sharing clinical, myopathological and biochemical findings with AVMs.MethodsWe applied a diagnostic protocol, recently published by our research group for suspected late‐onset GSDII (LO‐GSDII), including counting PAS‐positive lymphocytes on blood smears, dried blood spot (DBS)‐GAA, muscle biopsy histological and immunofluorescence studies, GAA activity assay and expression studies on muscle homogenate, GAA sequencing, GAA multiplex ligation‐dependent probe amplification (MLPA) and whole exome sequencing (WES).ResultsThe patients had a limb girdle‐like muscular pattern with persistent hyperCKaemia; vacuolated PAS‐positive lymphocytes, glycogen accumulation and impaired autophagy at muscle biopsy. Decreased GAA activity was also measured. While GAA sequencing identified no pathogenic mutations, WES approach allowed us to identify for each patient an unexpected mutational pattern in genes cooperating in lysosomal‐autophagic machinery, some of which have never been linked to human diseases.ConclusionsOur data suggest that reduced GAA activity may occur in any condition of impaired autophagy and that WES approach is advisable in all genetically undefined cases of autophagic myopathy. Therefore, deficiency of GAA activity and PAS‐positive lymphocytes should be considered as AVM markers together with LC3/p62‐positive autophagic vacuoles.
Oral pigmented lesions in syndromic individuals: A systematic review
Authors: Ferreira Luíse dos Santos , Calderipe Camila Barcellos , Maass Julianne Bartz , Carrard Vinicius Coelho , Martins Manoela Domingues , Abreu Lucas Guimarães , Schuch Lauren Frenzel , Uchoa Vasconcelos Ana Carolina 
Published: January 2021

AbstractObjectiveTo systematically integrate the available data published in the literature on oral pigmented lesions (OPL) associated with syndromes, summarizing the clinical and demographic features of the individuals.Materials and MethodsAn electronic search was undertaken in six databases. Eligibility criteria were articles in English, Spanish, and Portuguese describing case reports or case series of OPL associated with syndromes. Data were aggregated and statistically evaluated.ResultsAbout 108 articles reporting 149 cases of individuals with syndromes were identified. Among the affected individuals, nine syndromes were reported. The mean age at diagnosis was 35.93 years (0.41 to 83 years), with a predilection for white (n = 85/85.86%) female (n = 102/68.46%) individuals. As regards the number of lesions, 109 (73.15%) were multiple and 40 (26.85%) were single. Lip represented the anatomical location more affected (122 cases/38.01%), followed by the buccal mucosa (100 cases/31.15%). Brownish lesions accounted for 82 (69.49%) cases. The mean time of evolution was 10.52 years (0.16 to 56 years). OPL preceding diagnosis of the syndrome was observed in 111 (74.50%) cases.ConclusionsAlthough these syndromes are uncommon, dentists should be able to recognize their manifestations, since oral manifestations can represent an important aspect in early diagnosis.
Increasing Temperature Counteracts the Negative Effect of UV Radiation on Growth and Photosynthetic Efficiency ofMicrocystis aeruginosaandRaphidiopsis raciborskii
Authors: Noyma Natália Pessoa , Mesquita Marcella C.B. , Roland Fábio , Marinho Marcelo Manzi , Huszar Vera L.M. , Lürling Miquel 
Published: January 2021

AbstractHigh temperature can promote cyanobacterial blooms, whereas ultraviolet radiation (UVR) can potentially depress cyanobacterial growth by damaging their photosynthetic apparatus. Although the damaging effect of UVR has been well documented, reports on the interactive effects of UV radiation exposure and warming on cyanobacteria remain scarce. To better understand the combined effects of temperature and UVR on cyanobacteria, two strains of nuisance species,Microcystis aeruginosa(MIRF) andRaphidiopsis raciborskii(formerlyCylindrospermopsis raciborskii,CYRF), were grown at 24°C and 28°C and were daily exposed to UVA + UVB (PAR + UVA+UVB) or only UVA (PAR + UVA) radiation. MIRF and CYRF growth rates were most affected by PAR + UVA+UVB treatment and to a lesser extent by the PAR + UVA treatment. Negative UVR effects on growth, Photosystem II (PSII) efficiency and photosynthesis were pronounced at 24°C when compared to that at 28°C. Our results showed a cumulative negative effect on PSII efficiency in MIRF, but not in CYRF. Hence, although higher temperature ameliorates UVR damage, interspecific differences may lead to deviating impacts on different species, and combined elevated temperature and UVR stress could influence species competition.
Binding Expedient of 2‐carbamido‐1,3‐indandione to Nucleic Acids: Potential Fluorescent Probe
Authors: Stoyanova Nina , Markova Nadezhda , Angelov Ivan , Philipova Irena , Enchev Venelin 
Published: January 2021

AbstractFluorescent and computational methods were used to elucidate the binding expedient of 2‐carbamido‐1,3‐indandione (CAID) tautomers to nucleotides. The dependence of the fluorescence emission of CAID loaded nucleic acids sequences to compound concentration, temperature and time variation was investigated. It was found that the subject compound binds to nucleic acids but does not intercalate. According to our quantum‐chemical calculations on the conjugation between CAID and nucleotides, the binding in the formed complexes may be through hydrogen bonds. Two possible types of complexes were considered—CAID to the phosphate group and CAID to the nucleobase. To estimate the binding affinity, the interaction energies of the formed complexes were calculated. Tautomer 2‐carboamide‐1‐hydroxy‐3‐oxo‐indane is preferred in the formation of complexes, and the phosphate group complexes were more stable. Generally, the guanosine and deoxyguanosine monophosphate complexes were the most preferred regardless of the complex type. Because of the lack of cytotoxic effect on untransformed cell lines of mouse embryo fibroblasts Balb/c 3T3 according to our previous report (Markova et al, (2017) Bulg Chem Commun, 49D, 221–226) and the affinity to nucleic acids, we can suggest that the subject compound could be suitable to be used as a novel type of fluorescent biomarker.
Ranked Choice Voting as a Generational Issue in Modern American Politics
Authors: McCarthy Devin , Santucci Jack 
Published: January 2021

Ranked Choice Voting (RCV) is a class of reforms increasingly used in the United States to replace plurality and runoff elections. We ask whether support for RCV taps a larger generational divide in politics. We consult five surveys, two of these from recent adoption campaigns, and all with different ways of asking about RCV support. Generation is a significant predictor in four of these samples, accounting for standard demographic factors and partisanship. This relationship also holds within black and Republican subgroups, two groups often thought to be less likely to support RCV. Finally, we find that dissatisfaction with “the way that democracy works in America” is a plausible link between generation and reform support. For better or worse, RCV has potential to divide two important voting blocs in America. Our results suggest that, rather than turn away from electoral politics, a disaffected young generation may turn to reform.Related ArticlesCormack, Lindsey. 2019. “Leveraging Peer‐to‐Peer Connections to Increase Voter Participation in Local Elections.” Politics & Policy 47 (2): 248‐266. https://doi.org/10.1111/polp.12297Fisher, Patrick. 2020. “Generational Replacement and the Impending Transformation of the American Electorate.” Politics & Policy 48 (1): 38‐68. https://doi.org/10.1111/polp.12340Shaykhutdinov, Renat. 2019. “Socialization, Rationality, and Age: Generational Gaps and the Attitudes toward the Chechen War in Russia.” Politics & Policy 47 (5): 931‐955. https://doi.org/10.1111/polp.12323
Micromechanics Approach for the Overall Elastic Properties of Ceramic Matrix Composites Incorporating Defect Structures
Authors: Kumar Rajesh S. 
Published: January 2021

Abstract
The initial mechanical response of ceramic matrix composites (CMCs) is linear until the proportional limit. This initial response is characterized by linear elastic properties, which are anisotropic due to the orientation and arrangement of fibers in the matrix. The linear elastic properties are needed during various phases of analysis and design of CMC components. CMCs are typically made with ceramic unidirectional (UD) or woven fiber preforms embedded in a ceramic matrix formed via various processing routes. The matrix processing of interest in this work is the polymer impregnation and pyrolysis (PIP) process. As this process involves pyrolysis to convert a preceramic polymer into ceramic, considerable volume shrinkage occurs in the material. This volume shrinkage can lead to significant defects in the final material in the form of porosity of various size, shape, and volume fraction. These defect structures can have a significant impact on the elastic and damage response of the material. In this paper, a multiscale micromechanics modeling framework is developed to study the effects of processing-induced defects on the linear elastic response of a PIP-derived CMC. A combination of analytical and computational micromechanics approaches is used to derive the overall elastic tensor of the CMC as a function of the underlying constituents and/or defect structures. It is shown that the volume fraction and aspect ratio of porosity at various length scales play an important role in accurate prediction of the elastic tensor. Specifically, it is shown that the through-thickness elastic tensor components cannot be predicted accurately using the micromechanics models unless the effects of defects are considered.
A Meta-Study of Qualitative Research on Social Support Related to Physical Activity Among Older Adults
Authors: Beselt L. Jayne , Patterson Michelle C. , McDonough Meghan H. , Hewson Jennifer , MacKay Scott 
Published: January 2021

Physical activity (PA) and social support have known benefits for the well-being and health of older adults, and social support is associated with PA behavior and positive affective experiences in PA contexts. The aim of this study was to synthesize qualitative research conducted on the experiences of social support related to PA among older adults (age ≥55 years). Following meta-study methodology, the authors searched nine databases and extracted information from 31 studies. Results were synthesized in terms of common themes and in light of theoretical and methodological perspectives used. The qualitative literature identifies supportive behaviors and social network outcomes which may be useful for informing how best to support older adults to be physically active. This literature rarely reflected the experiences of vulnerable populations, and future research should aim to further understand supportive behaviors which enable older adults to overcome barriers and challenges to being physically active.
Timing of closure of the Meso-Tethys Ocean: Constraints from remnants of a 141–135 Ma ocean island within the Bangong–Nujiang Suture Zone, Tibetan Plateau
Authors: Fan Jian-Jun , Niu Yaoling , Liu Yi-Ming , Hao Yu-Jie 
Published: January 2021

AbstractKnowledge of the timing of the closure of the Meso-Tethys Ocean as represented by the Bangong–Nujiang Suture Zone, i.e., the timing of the Lhasa-Qiangtang collision, is critical for understanding the Mesozoic tectonics of the Tibetan Plateau. But this timing is hotly debated; existing suggestions vary from the Middle Jurassic (ca. 166 Ma) to Late Cretaceous (ca. 100 Ma). In this study, we describe the petrology of the Zhonggang igneous–sedimentary rocks in the middle segment of the Bangong–Nujiang Suture Zone and present results of zircon U–Pb geochronology, whole-rock geochemistry, and Sr–Nd isotope analysis of the Zhonggang igneous rocks. The Zhonggang igneous–sedimentary rocks have a thick basaltic basement (&gt;2 km thick) covered by limestone with interbedded basalt and tuff, trachyandesite, chert, and poorly sorted conglomerate comprising limestone and basalt debris. There is an absence of terrigenous detritus (e.g., quartz) within the sedimentary and pyroclastic rocks. These observations, together with the typical exotic blocks-in-matrix structure between the Zhonggang igneous–sedimentary rocks and the surrounding flysch deposits, lead to the conclusion that the Zhonggang igneous–sedimentary rocks are remnants of an ocean island within the Meso-Tethys Ocean. This conclusion is consistent with the ocean island basalt-type geochemistry of the Zhonggang basalts and trachyandesites, which are enriched in light rare earth elements (LaN/YbN = 4.72–18.1 and 5.61–13.7, respectively) and have positive Nb–Ta anomalies (NbPM/ThPM &gt; 1, TaPM/UPM &gt; 1), low initial 87Sr/86Sr ratios (0.703992–0.705428), and positive mantle εNd(t) values (3.88–5.99). Zircon U–Pb dates indicate that the Zhonggang ocean island formed at 141–135 Ma; therefore, closure of the Meso-Tethys Ocean and collision of the Lhasa and Qiangtang terranes must have happened after ca. 135 Ma.