bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantification of Microtubule Stutters: Dynamic Instability Behaviors that are Strongly Associated with Catastrophe
Authors: Mahserejian Shant M. , Scripture Jared P. , Mauro Ava J. , Lawrence Elizabeth J. , Jonasson Erin M. , Murray Kristopher S. , Li Jun , Gardner Melissa , Alber Mark , Zanic Marija , Goodson Holly V. 
Published: December 2019

ABSTRACTMicrotubules (MTs) are cytoskeletal fibers that undergo dynamic instability (DI), a remarkable process involving phases of growth and shortening separated by stochastic transitions called catastrophe and rescue. Dissecting dynamic instability mechanism(s) requires first characterizing and quantifying these dynamics, a subjective process that often ignores complexity in MT behavior. We present aStatisticalTool forAutomatedDynamicInstabilityAnalysis (STADIA), which identifies and quantifies not only growth and shortening, but also a category of intermediate behaviors that we term ‘stutters.’ During stutters, the rate of MT length change tends to be smaller in magnitude than during typical growth or shortening phases. Quantifying stutters and other behaviors with STADIA demonstrates that stutters precede most catastrophes in our dimer-scale MT simulations andin vitroexperiments, suggesting that stutters are mechanistically involved in catastrophes. Related to this idea, we show that the anti-catastrophe factor CLASP2γ works by promoting the return of stuttering MTs to growth. STADIA enables more comprehensive and data-driven analysis of MT dynamics compared to previous methods. The treatment of stutters as distinct and quantifiable DI behaviors provides new opportunities for analyzing mechanisms of MT dynamics and their regulation by binding proteins.
Building a bulletproof whistleblowing environment: an accountant’s perspective
Authors: Rajeevan Shanmugavel 
Published: December 2019

Purpose
The purpose of this paper is to assess the appropriateness of the factors that contribute to building a better whistleblowing environment and culture within an organisation and provide guidelines on how to build a better whistleblowing environment within an organisation.

Design/methodology/approach
In total, 592 questionnaires were circulated to 148 accounting firms licensed to carry out statutory audits of public limited companies expecting responses from 4 stakeholders from each entity. Out of the 592 questionnaires, only 148 questionnaires were usable, representing a 25 per cent overall response rate.

Findings
It is recommended to encourage a proactive whistleblowing environment by encouraging whistleblowing culture among employees of the organisations. However, there is disagreement among the respondents for some of the selected components that contribute to building a better whistleblowing environment and culture within an organisation.

Practical implications
The findings of this study can be used by the management of the organisations to identify frail areas of whistleblowing initiatives within the organisation and take remedial actions rectify the issues. Authorities can use the findings of the study to implement or amend the existing rules and regulations to encourage whistleblowing.

Originality/value
This study in contrast to the existing studies on determinants of whistleblowing attributes, provides knowledge on developing components/guidelines to encourage whistleblowing attributes and culture.
Innovation and co-creation in knowledge intensive business services: the Spinner model
Authors: Figueiredo Ronnie , Ferreira João J.M. , Silveira Rogério Guerra , Villarinho Alvaro Teixeira 
Published: December 2019

Purpose
The purpose of this paper is to analyse the propensity for innovation and co-creation in service companies in receipt of knowledge intensive business services (KIBS) type services through their intensive incorporation of knowledge.

Design/methodology/approach
In order to achieve this study objective, the authors first carried out a literature review in order to specify the scope of the construct; second, the authors applied a survey based on the “Spinner model”; third, the authors undertook research on KIBS clients and restricted the results to this population sample; and fourth, based on the validated and applied models deriving from the base construct, the authors presented the results obtained.

Findings
This concludes that the “Spinner” model is valid for explaining the propensity for innovation and co-creation in companies receiving KIBS. The results demonstrate evidence of innovation processes as a result of the intensive application of knowledge associated with co-creation and knowledge transfers.

Research limitations/implications
This provides managers with a better understanding of the barriers that may obstruct the implementation of co-creation and knowledge transfers. Hence, the variables analysed may guide managers in defining and planning innovation strategies. Furthermore, this enables each company receiving such services to validate them and establish indices for the innovation propensity of specialist (knowledge intensive) service providers within the framework of benchmarking exercises.

Originality/value
This study sets out a new means of analysing the propensity for innovation and the co-creation of knowledge by companies making recourse to knowledge intensive services. From the theoretical point of view, this defines a new construct and a means of classification for companies supplying services designed for their propensity for innovation and co-creation. From the practical perspective, this study provides the companies subject to research with the opportunity to perceive their respective position in relation to other companies. In addition to this, ranking companies in such a way may drive the need to develop new knowledge for future co-creation and innovation processes.
Executive education program faculty leaders: their “BASIC” roles
Authors: Haskins Mark E. 
Published: December 2019

Purpose
This article highlights and codifies the primary responsibilities of those individuals tasked with leading an executive education (EE) custom program design, development, and delivery team. The perspective presented is comprehensive and client centric.

Design/methodology/approach
The personal insights presented are based on over 20 years of serving as an EE program faculty leader (FL) on some of the largest and longest-running custom clients at one of the world’s premiere EE providers, while also observing others serving in that same capacity on other clients.

Findings
The primary, ongoing responsibilities of a FL are presented in a fashion analogous to the key players in the custom home building setting. Those roles are: architect, builder, supervisor, inspector, and client liaison. Each role is highlighted and explained.

Practical implications
The FL roles described herein are easily understood and immediately actionable as a robust array of priorities for those potentially cast in a FL role or its equivalent.

Originality/value
The EE role of FL is an important one. This article is unique providing a robust and succinct depiction of the multi-faceted role for FLs to embrace in order to richly and effectively fulfill that position.
Application of lean in construction using value stream mapping
Authors: Ramani Prasanna Venkatesan , KSD Laxmana Kumara Lingan 
Published: December 2019

PurposeLean construction is a technique that aims at reducing waste in construction and maximizing productivity. The purpose of this paper is to discuss the effectiveness of Lean technique in managing construction projects.Design/methodology/approachA case study of structural steel erection project was chosen where the value stream mapping lean tool is applied and the possible improvement in productivity was observed. The current state of the activities in the erection process was mapped first which was followed by preparing the Future State Map of the activities after eliminating the non-value adding tasks.FindingsThe modifications from Future State Map were carried out at the project and the results exhibited a substantial increase in productivity by reducing the project duration by 13 days which is about 30 per cent savings from the expected completion time after the implementation of Lean technique.Originality/valueTraditionally lean concept has been widely used in process-oriented manufacturing industry whereas it is relatively new to the project-oriented construction industry. This current research has focused on applying lean tool to a real time construction project at the site level and measuring its outcome practically. The results of this study are real and affirm the effectiveness of applying lean concept to construction projects. It will be major paradigm shift in terms of managing construction projects.
Colegio Brillo De Luna. Modelo De Negocio Sostenible
Authors: Villalobos Araya Rodrigo 
Published: December 2019

Learning outcomes
En cursos de Emprendimiento el caso permitiría debatir el aporte de la innovación social. Por otra parte, en cursos de Estrategia el caso permitiría diseñar el modelo de negocio para un emprendimiento social, evaluar la creación, entrega y captura de valor de una empresa social. Dependiendo del curso y el enfoque que quiera dársele a la discusión del caso, puede servir como soporte para los siguientes objetivos: Comprensión de conceptos: • Explicar el aporte de la innovación social para la solución de problemáticas de una región. • Describir los recursos y propuesta de valor del modelo de negocio de una empresa social. Fomento de actitudes: • Comprender la importancia de la ética y la responsabilidad en el desarrollo de emprendimientos sociales.

Case overview/synopsis
El caso aborda la oportunidad que tiene el Colegio Especial Brillo de Luna, al desarrollar un emprendimiento social, el cual requiere proyección, evaluación y apoyo a la gestión. En este contexto la directora del colegio debe proponer un modelo de negocio que sea sostenible a largo plazo en el mercado y que genere valor compartido. La relación institucional del Colegio Brillo de Luna con la empresa Cristalchile, a través del emprendimiento social del reciclaje de vidrio, podría generar valor económico, medioambiental y social a la comunidad escolar y la empresa.

Complexity academic level
Cursos en los que podría aplicarse el caso: Emprendimiento, Estrategia.

Supplementary materials
Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 3: Entrepreneurship.
Aplicación de convenios de comercialización en genéricos farmacéuticos: un análisis de la marca Starpram de Maple Pharmaceuticals
Authors: Padela Shoaib M. Farooq , Qureshi Jawaid Ahmed , Bashir Salman 
Published: December 2019

Learning outcomes
(Core) Objetivos de aprendizaje esperados (y resultados): 1) comprender las decisiones de posicionamiento de marca, construcción de marca y extensión de categoría de una marca farmacéutica (operativa en una de las industrias más competitivas y reguladas de un país en desarrollo); 2) analizar los resultados de las decisiones relacionadas con ventas estratégicas, creación de marca, marketing y reestructuración estratégica para superar los desafíos del crecimiento; y 3) Diseñar soluciones estratégicas para el desarrollo de la marca.

Case overview/synopsis
Este caso explora la estrategia de lanzar y establecer una marca farmacéutica en una industria que tiende a ser una industria altamente técnica y la más regulada. Representa datos de investigación de mercado, análisis de la industria, dura competencia, asuntos regulatorios y elabora diversas decisiones estratégicas tomadas por la empresa. Los datos primarios para el caso se acumulan a través de entrevistas en profundidad de seis expertos de la industria en marketing farmacéutico que estaban bien familiarizados con Maple Pharma y datos secundarios se extraen de la literatura sustantiva. Maple Pharmaceuticals lanzó Starpram, una marca de antidepresivos genéricos de alto crecimiento y alto potencial (en la categoría de sistema nervioso central) que contiene la molécula / sustancia química de escitalopram. Tenía experiencia y ventaja competitiva en flujos cardiovasculares y antidiabéticos, pero dicha iniciativa parecía tener una extensión de categoría, con la intención de diversificar el riesgo y expandir la compañía para lograr mayores economías de escala. El primer año en que los ingresos por ventas de Starpram parecieron demasiado sombríos como para estimular la inauguración de nuevos productos. En consecuencia, se realizó una revisión estratégica para establecer la marca en la industria farmacéutica altamente fragmentada. La empresa carecía de experiencia en la categoría de antidepresivos, junto con ventas deficientes, combinación de marketing y estrategia de marketing en general. Finalmente, la gerencia ejerció una reestructuración estratégica para establecer el valor de marca y el crecimiento observado.

Complexity academic level
Licenciados (MBA), MS, PhD (ciencias de la administración).

Subject Code
CSS 8: Marketing.
Prey: Reteniendo talento ad portas de una alianza con Policía de Investigaciones
Authors: Kuschel Katherina , Cotapos Francisco , González Miguel-Ángel , Salcedo Nestor U. 
Published: December 2019

Learning outcomes
Un estudiante de este programa podrá evaluar eficazmente las variables relacionadas con la decisión de una alianza estratégica para el crecimiento mientras, simultáneamente se enfrenta a otras dificultades internas, como lidiar con un equipo “no comprometido”. Además, el estudiante podrá equilibrar y ponderar de manera efectiva los recursos actuales y necesarios, entendiendo que los marcos conceptuales POLC y FODA son útiles y válidos para entender compañías jóvenes basadas en alta tecnología.

Case overview/synopsis
El caso cuenta la historia de Tomás Pollak, fundador y CEO de Prey Project, una compañía de software que rastrea equipos robados. El caso cubre el período de 6 años, desde la fundación de la empresa en 2009, hasta su situación en julio de 2015, cuando la compañía enfrentó la decisión de implementar o no una alianza con una institución pública: Policía de Investigaciones de Chile. Tomás debe decidir si toma o no la oportunidad, a la vez que intenta desesperadamente reclutar y retener el talento de la compañía. Este caso destaca varios desafíos de administración y estrategia que comúnmente enfrentan emprendedores, y busca generar discusión en clase sobre cómo estos conceptos de administración siguen siendo relevantes para una startup.

Complexity academic level
Estudiantes de pregrado y postgrado o MBA. Cursos de Creación de Negocios, Emprendimiento Tecnológico, Administración/Gestión, Dirección Estratégica/Estrategia.

Supplementary materials
Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 3: Entrepreneurship.
Institutional investors vs retail investors
Authors: Jaiyeoba Haruna Babatunde , Abdullah Moha Asri , Ibrahim Khairunisah 
Published: December 2019

Purpose
Guided by several pioneered studies, the purpose of this paper is to comprehensively investigate the investment behaviours of Malaysian retail and institutional investors in an attempt to identify whether the influence of psychological biases is equally applicable to investor divides.

Design/methodology/approach
The researchers have adopted a quantitative research design by way of survey methodology to obtain data from institutional and retail investors in Malaysia. In addition, the authors have mainly employed second-order measurement invariance analysis to uncover the difference across investor divides.

Findings
The tests of measurement invariance at the model level indicate an insignificant difference between institutional investors and retail investors. The post hoc test (at the path level) reveals that institutional and retail investors are similar with respect to representative heuristic, overconfidence bias and anchoring bias; though the results also show that they are different with respect to religious bias and herding bias.

Research limitations/implications
Based on the findings of this study, it is generally not logical to assume that institutional investors completely behave rational during investment decisions. Besides, future researchers are called upon to directly compare the investment decisions of institutional and retail investors with respect to whether the influence of psychological biases is equally applicable to them, particularly on the investigated psychological biases and other psychological biases that are not covered in this study.

Originality/value
This study has offered insight into whether the influence of psychological biases is equally applicable to institutional and retail investors in Malaysia using second-order measurement invariance analysis. This study is unique in context and the approach it has adopted.
School technology leadership vision and challenges
Authors: Gonzales Miguel M. 
Published: December 2019

Purpose
The purpose of this paper is to examine the significant challenges school administrators encountered leading a one-to-one laptop school and what vision school administrators have for one-to-one laptop use in the classroom.

Design/methodology/approach
The methodology for this study was a case study approach. In total, 15 school administrators were interviewed from the Western region of the USA.

Findings
Results from the study indicated that significant challenges for school administrators were budgeting and sustaining the initiative, and negotiating and setting expectations for instructional use with teachers. School administrators also envisioned one-to-one laptop use as a mean to enhance student-centered learning and inquiry.

Research limitations/implications
Further research is needed which examines how school administrators make financial decisions in regards to sustaining one-on-one laptop initiatives and how they manage conflict with teachers in respect to one-to-one laptop instruction.

Originality/value
Minimal literature exists which examines the challenges and vision of school technology leaders. Policy-makers and school administrators can use the findings to recreate teacher evaluation forms, develop conflict management strategies and teaching standards that are aligned and conducive to one-to-one laptop schools.
The impact of foreign capital inflows on economic growth and employment in Egypt
Authors: Abouelfarag Hanan AbdelKhalik , Abed Mohamed Sayed 
Published: December 2019

Purpose
The purpose of this paper is to trace the effects of both foreign direct investment (FDI) and external debt on economic growth and employment in Egypt over the 1985–2014 period.

Design/methodology/approach
The empirical analysis includes three stages: an aggregate time series analysis, a panel model that includes six economic sectors and a set of single-sector models. The “autoregressive distributed lag” approach is utilized either in the time series or in the panel models.

Findings
The empirical results of this research reveal that foreign investment exerts a weak positive effect on economic growth and employment in Egypt. External debt exerts an insignificant effect on economic growth and employment in the aggregate model. The sectoral analysis reveals that the effect varies greatly between sectors; the effect of FDI on output is positive in the financial, tourism and other service sectors, while it is insignificant in the agricultural, construction and manufacturing sectors.

Practical implications
It is important not to depend on external debt as an easy way to obtain capital. Greater efforts should be exerted to increase the absorptive capacity of the Egyptian economy so as to benefit from the positive spillover effect of foreign investment as much as possible.

Originality/value
With respect to Egypt, very limited studies have focussed on the role of external debt on growth and that of FDI and external debt on the employment level. There is no general agreement concerning the effect of FDI on economic growth. Therefore, this research explores the effect of FDI and external debt on the Egyptian economy utilizing both aggregate and sectoral data.
A novel generalized thermoelasticity with higher-order time-derivatives and three-phase lags
Authors: Abouelregal Ahmed E. 
Published: December 2019

Purpose
In this work, a modified thermoelastic model of heat conduction, including higher order of time derivative, is constructed by extending the Roychoudhuri model (TPL) (Choudhuri, 2007). In this new model, Fourier’s law of heat conduction is replaced by using Taylor series expansions, including three different phase lags for the heat flux, the thermal displacement and the temperature gradient. The generalized thermoelasticity models of Lord–Shulman (Lord and Shulman, 1967), Green and Naghdi (1991), dual-phase lag (Tzou, 1996) and three-phase lag (TPL) (Choudhuri, 2007) are obtained as special cases. The paper aims to discuss these issues.

Design/methodology/approach
The aim of this work is to establish a new generalized mathematical model of thermoelasticity that includes TPL in the vector of heat flux, and in the thermal displacement and temperature gradients extending TPL model (Li et al., 2019e). In this model, Fourier law of heat conduction is replaced by using Taylor series expansions to a modification of the Fourier law with introducing three different phase lags for the heat flux vector, the temperature gradient, and the thermal displacement gradient and keeping terms up with suitable higher orders.

Findings
The established high-order three-phase-lag heat conduction model reduces to the previous models of thermoelasticity as special cases.

Originality/value
In this paper, a TPL thermoelastic model is developed by extending the Roychoudhuri (Sherief and Raslan, 2017) model (TPL) considering the Taylor series approximation of the equation of heat conduction. This model is an alternative construction to the TPL model. The new model includes high order of TPL in the vector of heat flux, and in the thermal displacement and temperature gradients.