bluuebunny/crossref_metadata_2025_split huggingface dataset:
Editors' Welcome
Authors: Erickson Ingrid , Vivacqua Adriana S. , Christensen Lars Rune , Holten Moller Naja L. , Baumer Eric , Wohn Yvette , Barkhuus Louise , Robert Lionel P. 
Published: December 2019

It is our pleasure to welcome you to the first PACMHCI GROUP issue. For over 25 years, the GROUP research community has supported the development of robust scholarship at the intersection of Computer Supported Cooperative Work, Human Computer Interaction, Computer Supported Collaborative Learning and Socio-Technical Studies. This volume is the latest product of our efforts to validate and integrate the strong work happening within this broadly-conceived community.
We hope that the range of papers presented here reflects our intent to be international, interdisciplinary, and inclusive, both in our organization of the review process as well as within the set of accepted papers. This first PACM journal volume in the GROUP series features studies of collaboration in multiple settings, including social networks, editing systems, and mixed reality. It also showcases sociotechnical studies in domains ranging from outdoor activities to scientific projects.
Reproducibility of Heart Rate Variability Revealed by Repeated Measurements during and after Hemodialysis
Authors: Deussing Kerstin , Wendt Ralph , Burger Ronald , Gollasch Maik , Beige Joachim 
Published: December 2019

<b><i>Background/Aims:</i></b> Trajectory of heart rate variability (HRV) represents a noninvasive real-time measure of autonomous nervous system (ANS) and carries the capability of providing new insights into the hemodynamic compensation reserve during hemodialysis (HD). However, studies on HRV reproducibility during HD are scarce and did not refer to different reading periods. In this observational study, we aimed to establish the best suited and most reliable and reproducible HRV index in routine HD treatments including different reading rates. <b><i>Methods:</i></b> HRV was characterized by standardized mathematical variation expressions of R/R’ intervals: SD of all R/R’ intervals (ms), square root of the root mean square of the sum of all differences between adjacent R/R’ intervals (ms), percentage of consecutive R/R’ intervals that differ by &#x3e;50 ms (%), low-frequency spectral analysis HRV (LF, expressing sympathetic activity), and high-frequency HRV (HF, expressing parasympathetic activity). To compare robustness of these HRV indices during HD procedures, we compared HRV indices means between different HD sessions and controlled for association with clinical parameters. <b><i>Results:</i></b> In 72 HD treatments of 34 patients, we detected the highest reproducibility (89%) of HRV measures when analyzing the low-frequency to high-frequency (LF/HF) ratio in long-term (3 h) readings. Long-term LF/HF was able to discriminate ­between patients with and without heart failure NYHA classes ≥3 (<i>p</i> = 0.009) and type 2 diabetes (<i>p</i> = 0.023). We were unable to study relationships between ANS and intradialytic complications because they did not appear in our cohort. Short-term readings of HRV indices did not show any significance of pattern change during HD. <b><i>Conclusion:</i></b> In summary, our data provide evidence for high robustness of long-term LF/HF in analyzing HRV in HD patients using future automated monitoring systems. For short-term analysis, mathematical real-time analysis must evolve.
Prospective Implementation of the Ottawa Subarachnoid Hemorrhage Rule and 6-Hour Computed Tomography Rule
Authors: Perry Jeffrey J. , Sivilotti Marco L.A. , Émond Marcel , Hohl Corinne M. , Khan Maryam , Lesiuk Howard , Abdulaziz Kasim , Wells George A. , Stiell Ian G. 
Published: December 2019

Background and Purpose—
The Ottawa subarachnoid hemorrhage (SAH) rule identifies patients with headache requiring no testing for SAH, while the 6-hour computed tomography (CT) rule guides when to forgo a lumbar puncture. Our objectives were to: (1) estimate the clinical impact of the Ottawa SAH rule and the 6-hour-CT rule on testing rates (ie, CT, lumbar puncture, CT angiography); (2) validate the 6-hour-CT rule for SAH when applied prospectively in a new cohort of patients.

Methods—

We conducted a multicenter prospective before/after implementation study from 2011 to 2016 with 6 months follow-up at 6 tertiary-care Canadian Academic Emergency Departments. Consecutive alert, neurologically intact adults with headache were included. For intervention period, physicians were given a 1-hour lecture, pocket cards, posters were installed, and physicians indicated Ottawa SAH rule criteria when ordering CTs. SAH was defined by blood on CT, xanthochromia in cerebrospinal fluid, or >1×10
6
/L red blood cells in cerebrospinal fluid with aneurysm.

Results—

We enrolled 3672 patients, 1743 before and 1929 after implementation, including 188 with SAH. Proportions undergoing CT was unchanged (88.0% versus 87.5%;
P
=0.643). Lumbar puncture use decreased (38.9% versus 25.9%;
P
<0.0001). Additional testing following CT (ie, lumbar puncture or CT angiography) decreased (51.3% versus 42.2%;
P
<0.0001). Admissions declined (9.8% versus 7.4%;
P
=0.011). Mean emergency department stay was unchanged (6.3±4.0 versus 6.4±4.2 hours;
P
=0.685). The Ottawa SAH rule was 100% (95% CI, 98.1%–100%) sensitive, and the 6-hour-CT rule was 95.5% (95% CI, 89.8–98.5) sensitive for SAH. The 6-hour-CT rule missed 5 SAHs: 1 radiology misread, 2 incidental aneurysms, 1 nonaneurysmal cause, and 1 profoundly anemic patient.

Conclusions—
The Ottawa SAH rule and the 6-hour-CT rule are highly sensitive and can be used routinely when SAH is considered in patients with headache. Implementing both rules was associated with a meaningful decrease in testing and admissions to hospital.
Deep Learning for Automated Measurement of Hemorrhage and Perihematomal Edema in Supratentorial Intracerebral Hemorrhage
Authors: Dhar Rajat , Falcone Guido J. , Chen Yasheng , Hamzehloo Ali , Kirsch Elayna P. , Noche Rommell B. , Roth Kilian , Acosta Julian , Ruiz Andres , Phuah Chia-Ling , Woo Daniel , Gill Thomas M. , Sheth Kevin N. , Lee Jin-Moo 
Published: December 2019

Background and Purpose—
Volumes of hemorrhage and perihematomal edema (PHE) are well-established biomarkers of primary and secondary injury, respectively, in spontaneous intracerebral hemorrhage. An automated imaging pipeline capable of accurately and rapidly quantifying these biomarkers would facilitate large cohort studies evaluating underlying mechanisms of injury.

Methods—
Regions of hemorrhage and PHE were manually delineated on computed tomography scans of patients enrolled in 2 intracerebral hemorrhage studies. Manual ground-truth masks from the first cohort were used to train a fully convolutional neural network to segment images into hemorrhage and PHE. The primary outcome was automated-versus-human concordance in hemorrhage and PHE volumes. The secondary outcome was voxel-by-voxel overlap of segmentations, quantified by the Dice similarity coefficient (DSC). Algorithm performance was validated on 84 scans from the second study.

Results—
Two hundred twenty-four scans from 124 patients with supratentorial intracerebral hemorrhage were used for algorithm derivation. Median volumes were 18 mL (interquartile range, 8–43) for hemorrhage and 12 mL (interquartile range, 5–30) for PHE. Concordance was excellent (0.96) for automated quantification of hemorrhage and good (0.81) for PHE, with DSC of 0.90 (interquartile range, 0.85–0.93) and 0.54 (0.39–0.65), respectively. External validation confirmed algorithm accuracy for hemorrhage (concordance 0.98, DSC 0.90) and PHE (concordance 0.90, DSC 0.55). This was comparable with the consistency observed between 2 human raters (DSC 0.90 for hemorrhage, 0.57 for PHE).

Conclusions—
We have developed a deep learning-based imaging algorithm capable of accurately measuring hemorrhage and PHE volumes. Rapid and consistent automated biomarker quantification may accelerate powerful and precise studies of disease biology in large cohorts of intracerebral hemorrhage patients.
Book Review: Xavier Bougarel (2018). "Islam and Nationhood in Bosnia-Hercegovina: Surviving Empires". London-New York: Bloomsbury Academic
Authors: Falski Maciej 
Published: December 2019

Book Review: Xavier Bougarel (2018). Islam and Nationhood in Bosnia-Hercegovina: Surviving Empires. London-New York: Bloomsbury AcademicThe review of the latest book by Xavier Bougarel focuses on the main concepts of the work: the notion of empire as a methodological and theoretical framework, the relation between Islam and the national idea, and the process of Bosniak nation-building. Recenzja książki: Xavier Bougarel (2018). Islam and Nationhood in Bosnia-Hercegovina: Surviving Empires. London-New York: Bloomsbury AcademicRecenzja najnowszej książki Xaviera Bougarela koncentruje się na najważniejszych kwestiach, takich jak: pojęcie imperium, będące ramą ideologiczną i teoretyczną dla interpretacji autora, relacja między Islamem a ideą narodową, oraz proces definiowania narodu boszniackiego.
Book Review: Siniša Malešević (2019). "Grounded Nationalisms". Cambridge: Cambridge University Press
Authors: Rawski Tomasz 
Published: December 2019

Book Review: Siniša Malešević (2019). Grounded Nationalisms. Cambridge: Cambridge University PressA review of the latest book by Siniša Malešević, an established theoretician of nationalism. The review not only indicates the main theoretical innovation of this work in relation to his previous works, but also identifies Malešević's twofold theoretical contribution to contemporary theories of nationalism. Recenzja książki: Siniša Malešević (2019). Grounded Nationalisms. Cambridge: Cambridge University PressRecenzja najnowszej pracy Sinišy Maleševicia, uznanego teoretyka nacjonalizmu. Recenzja nie tylko wskazuje główną innowację teoretyczną tej pracy w stosunku do prac poprzednich, ale także identyfikuje dwojaki teoretyczny wkład Maleševicia we współczesne teorie nacjonalizmu.
Integration of occupational therapists into family medicine groups: Physicians’ perspectives
Authors: Locas Valérie , Préfontaine Cassandra , Veillette Nathalie , Vachon Brigitte 
Published: December 2019

Introduction Occupational therapists remain poorly integrated into family medicine groups in Canada. Physicians are key partners because they can advocate for resources and formulate recommendations to improve the quality of services delivered in their clinics. It is important to explore their perception of the occupational therapist’s role in family medicine groups and the factors influencing their integration. Method A descriptive qualitative study was conducted. Six family physicians participated in an individual interview. Results were analysed using thematic analysis. Results Physicians consider that occupational therapists can meet the needs of diverse primary care clients. Benefits of this integration include improved clients’ functional status, early screening for developmental and age-related problems, and timely access to required care. The main barriers to integration are lack of funding, space and knowledge of the occupational therapist’s role. The strategies identified to facilitate integration are promoting and clarifying the role of occupational therapists in family medicine groups and developing effective integration models. Conclusion According to physicians, the inclusion of occupational therapists in family medicine groups could help primary care teams address many of their clients’ needs and improve the overall quality of primary care services. Targeted strategies are needed to promote the integration of occupational therapists into this practice context.
Influence of arm position change from adduction to abduction on intracavitary electrocardiogram
Authors: Zhu Shu-shu , Zhao Jing , Zhou Xin-yu , Gao Wei , Pan Ming-hao , Yu Wei-wei , Hao Hai-xia , Zhang Hai-jun , Yu De-xin , Wang Qing-yan , Huang Ping , Yin Yu-xia , Wang Lei 
Published: December 2019

Purpose: The aim of this study is to evaluate the influence of arm movements from adduction to abduction on intracavitary electrocardiogram and the position of a catheter tip. Methods: Overall, 192 peripherally inserted central catheter lines were placed under intracavitary electrocardiogram guidance and 188 of them were enrolled in the study. The catheter was first placed at a time point corresponding to the peak P wave with the arm in adduction. The arm was then abducted to 90° without changing catheter insertion length. During the procedure, basal electrocardiogram, intracavitary electrocardiogram, and radiographs with the arm in adduction and abduction were recorded. Amplitude wave changes and catheter movements were measured on electrocardiogram records and radiographs, respectively. Results: In 188 cases, the P wave displayed typical changes, and 97.8% (184/188) catheters were successfully placed correctly. At the peak P wave, the amplitude of the peak P wave was 8.64 times greater than that of the basal P wave, and the P/R ratio was 0.61. When the arm was abducted to 90°, the amplitude of the P wave dropped to 57% of its peak, P/R decreased from 0.61 to 0.34, and the catheter tip moved cephalad 1.00 and 0.77 vertebral body units in male and female patients, respectively. Conclusion: Peripherally inserted central catheter moves toward the heart when the arm position changes from abduction to adduction. Peripherally inserted central catheter tip placement at the peak P wave with patient’s arm in adduction is accurate and can prevent the catheter from advancing too low. R wave can function as a reference for observing P wave changes during peripherally inserted central catheter placement.
Assessing the Ankle Joint Line Level Before and After Total Ankle Arthroplasty With the “Joint Line Height Ratio”
Authors: Harnroongroj Thos , Hummel Amelia , Ellis Scott J. , Sofka Carolyn M. , Caolo Kristin C. , Deland Jonathan T. , Demetracopoulos Constantine A. 
Published: December 2019

Background: Restoring the joint line is an important principle in total knee arthroplasty. However, the effect of joint line level on patient outcomes after total ankle arthroplasty (TAA) remains unclear, as there is no established method for measuring ankle joint level in TAA. The objective of this study was to develop a reliable radiographic ankle joint line measurement method and to compare ankle joint line level measured pre-TAA, post-TAA, and in nonarthritic ankles. Methods: A total of 112 radiographic sets were analyzed. Each set included weightbearing anteroposterior radiographs of the operative ankle taken preoperatively, 1-year postoperatively, and of the contralateral ankle. Measurements of vertical intermalleolar distance (VIMD) and vertical joint line distance (VJLD) at pre-TAA, post-TAA, and of the contralateral ankle were recorded by 2 authors on 2 separate occasions. The ratio of VJLD to VIMD was defined as the joint line height ratio (JLHR). Reliability of measurements and correlation between VIMD and VJLD were assessed. Pre-TAA, nonarthritic contralateral ankle, and post-TAA JLHR were compared and considered significantly different if P <.05. Results: The inter- and intrarater reliability of radiographic measurements was excellent ( r > 0.9). There were strong positive correlations of VIMD and VJLD, r = 0.809 (pre-TAA)/0.756 (post-TAA), P < .001. Mean (SD) pre-TAA, nonarthritic contralateral ankle, and post-TAA JLHRs were 1.54 (0.31), 1.39 (0.26), and 1.62 (0.49), respectively. Pre- and post-TAA JLHRs were significantly higher compared to the nonarthritic contralateral ankle ( P < .05). JHLR was not significantly different between pre- and post-TAA ( P = .15). Conclusion: The JLHR was reliable and could be a clinically applicable method for assessing ankle joint line level in patients undergoing TAA. End-stage ankle arthritis demonstrated elevated joint line level compared with nonarthritic ankles, and the joint line level post-TAA remained elevated compared with nonarthritic ankles. Further studies are needed to understand the effect of joint line elevation on clinical outcomes after TAA. Level of Evidence: Level III, retrospective comparative study.
India’s Economic Integration in Services with ASEAN: From Bilateral FTAs to RCEP
Authors: Gupta Pralok 
Published: December 2019

Given the growing importance of services in Indian economy as well as in international trade, India has offensive interests in services and these are becoming an important part of India’s effort to economically integrate with global economies including Association of Southeast Asian Nations (ASEAN). This article analyses India’s economic integration with the ASEAN region in services trade and discusses how India’s services trade interests are taken into consideration by ASEAN members in their free trade agreements with India. It also discusses services-related aspects in the Regional Comprehensive Economic Partnership agreement, a proposed free trade agreement among ASEAN and its six FTA partners including India, from which India has decided to opt-out recently. JEL Codes: F13, F14, F15
End points for sickle cell disease clinical trials: renal and cardiopulmonary, cure, and low-resource settings
Authors: Farrell Ann T. , Panepinto Julie , Desai Ankit A. , Kassim Adetola A. , Lebensburger Jeffrey , Walters Mark C. , Bauer Daniel E. , Blaylark Rae M. , DiMichele Donna M. , Gladwin Mark T. , Green Nancy S. , Hassell Kathryn , Kato Gregory J. , Klings Elizabeth S. , Kohn Donald B. , Krishnamurti Lakshmanan , Little Jane , Makani Julie , Malik Punam , McGann Patrick T. , Minniti Caterina , Morris Claudia R. , Odame Isaac , Oneal Patricia Ann , Setse Rosanna , Sharma Poornima , Shenoy Shalini 
Published: December 2019

AbstractTo address the global burden of sickle cell disease and the need for novel therapies, the American Society of Hematology partnered with the US Food and Drug Administration to engage the work of 7 panels of clinicians, investigators, and patients to develop consensus recommendations for clinical trial end points. The panels conducted their work through literature reviews, assessment of available evidence, and expert judgment focusing on end points related to patient-reported outcome, pain (non–patient-reported outcomes), the brain, end-organ considerations, biomarkers, measurement of cure, and low-resource settings. This article presents the findings and recommendations of the end-organ considerations, measurement of cure, and low-resource settings panels as well as relevant findings and recommendations from the biomarkers panel.
Cause-specific late mortality after allogeneic stem cell transplantation
Authors: Bhatia Smita 
Published: December 2019

Abstract
Conditional on surviving the first 2 to 5 years after allogeneic blood or marrow transplantation (BMT), the 10-year overall survival approaches 80%. Nonetheless, the risk of late mortality remains higher than the age- and sex-matched general population for several years after BMT. The higher mortality rates in transplant recipients translate into shorter projected life expectancies compared with the general population. Risk of relapse-related mortality reaches a plateau within 10 years after BMT. With increasing time from BMT, nonrelapse-related mortality becomes the leading cause of death, and continues to increase with time after BMT. The major causes of nonrelapse mortality include infection (with or without chronic graft-versus-host disease), subsequent neoplasms, and cardiopulmonary compromise. In this review, findings from large cohorts are summarized, identifying opportunities for risk-based anticipatory intervention strategies to reduce mortality.
Pediatric-inspired protocols in adult acute lymphoblastic leukemia: are the results bearing fruit?
Authors: Muffly Lori , Curran Emily 
Published: December 2019

Abstract
Observational findings demonstrating improved survival for younger adults following pediatric, as opposed to adult, acute lymphoblastic leukemia (ALL) regimens have been translated into international, prospective multicenter clinical trials testing the pediatric regimen in young adult ALL. The results of these studies confirm the feasibility of delivering the pediatric regimen in the adult oncology setting and establish the superiority of this approach relative to historical adult cooperative group regimen results. Specific toxicities, including thrombosis, hepatotoxicity, and osteonecrosis, are more prevalent in adults receiving the pediatric regimen relative to young children. Persistent minimal residual disease (MRD) is a strong prognostic indicator in adults receiving the pediatric regimen; sensitive, high-quality MRD evaluation should be performed in all patients receiving these therapies. Incorporation of targeted agents, particularly in the frontline and MRD+ setting, will usher in the next era of the pediatric regimen in adult ALL.
Mechanisms of and approaches to overcoming resistance to immunotherapy
Authors: Schultz Liora , Gardner Rebecca 
Published: December 2019

AbstractImmunotherapies have been successfully developed for the treatment of B-cell acute lymphoblastic leukemia (B-ALL) with FDA approval of blinatumomab, inotuzumab, and tisagenlecleucel for relapsed or refractory patients. These agents target either CD19 or CD22, which are both expressed on the surface of the leukemic blasts in the majority of patients. The use of these agents has greatly transformed the landscape of available treatment, and it has provided curative therapy in some patients. As the field has matured, we are learning that for most patients, the currently available immunotherapies are not curative. Leukemic resistance to both CD19 and CD22 pressure has been described and is a major component of developed resistance to these therapies. Patients with B-ALL have developed CD19- or CD22-negative B-ALL, and in more rare cases, they have undergone lineage switch to acute myeloid leukemia. Current efforts are focusing on overcoming antigen escape, either by forced antigen expression or by dual-targeting therapies. A functional immune system is also required for maximal benefit of immunotherapy, particularly with chimeric antigen receptor (CAR) T-cell therapies. Data are now being produced that may allow for the prospective identification of patients whose immune deficits may be identified up front and predict failure. Preclinical work is focusing on additional engineering of CAR T cells to overcome these inherent immune deficits. Last, with improved knowledge of which patients are likely to benefit from immunotherapy as definitive treatment, those patients who are predicted to develop resistance may be prospectively recommended to undergo a consolidative hematopoietic cell transplant to lessen the recurrence risk.
Novel agents and immune invasion in Hodgkin lymphoma
Authors: Merryman Reid W. , LaCasce Ann 
Published: December 2019

Abstract
The approval of brentuximab vedotin (BV) and the PD-1 inhibitors nivolumab and pembrolizumab has dramatically improved outcomes for patients with relapsed or refractory (R/R) classic Hodgkin lymphoma (HL). With the goal of increasing long-term disease control rates and decreasing late toxicities, these agents are currently being tested in earlier phases of treatment in combination with chemotherapy agents. In the R/R setting, our expanding understanding of HL’s various mechanisms of immune evasion and treatment resistance has spurred a growing number of rationally designed combination trials. Beyond BV and PD-1 blockade, other novel therapies have demonstrated encouraging preliminary results, including targeted agents, like the CD25 antibody-drug conjugate ADCT-301, and cellular therapies, including CD30 chimeric antigen receptor T cells and Epstein-Barr virus (EBV)-directed cytotoxic T cells. These trials, coupled with the rapid development of prognostic and predictive biomarkers, should drive additional breakthroughs that promise safer and more effective therapies for patients with HL in the future.