bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of minimally invasive management in patients with forgotten double J stent: a single centre experience
Authors: Ahmed Mohd Hamid Shafique , Toshniwal Harshad , Pawar Prakash W. , Sawant Ajit S. , Arora Amandeep , Abbas Syed Ali , Sakharani Jitendra K. , Shah Neel 
Published: December 2019

Background: aim of the study was to present the experience in managing forgotten/encrusted Double J (DJ) ureteral stents and to review the literature on the subject.Methods: Author retrospectively studied patients presenting to the Outpatient Department from January 2016 to January 2019 with forgotten DJ stent(s) (six or more than six months after the insertion). Data was collected for age, gender, indication for DJ stenting, clinical features at presentation, radiological imaging and surgical procedure performed to extract the DJ stents. The post-operative stay, complications of the procedures and morbidity was also studied.Results: During the study period, a total 32 patients reported to the department with history of forgotten DJ stents. Most common age group involved was 41-60 years. Most common presenting symptoms were lower urinary tract symptoms (LUTS) or dysuria. Duration of stent in-situ ranged from 6 month to 15 years. Most common sites of encrustations along the forgotten DJ stent were ureter and kidney followed by urinary blabber. Fluoroscopic guided DJ stent removal was done in 8 patients. A combination of Cystolithotripsy, URSL and PCNL was needed to clear the stone and extract the DJ stent in remaining patients.Conclusions: Forgotten/encrusted DJ stent may lead to complications ranging from urinary tract infections to loss of renal function. They can be safely and successfully removed, and the renal function can be preserved. Endo-urological management of forgotten encrusted stents is highly successful and often avoids the need for open surgical techniques.
Reflexiones sobre la pertinencia de hablar de una “creación escénica ante el espectador”
Authors: Chevallier Jean-Frédéric 
Published: December 2019

Para describir la actividad del artista, se suele recurrir a la noción de "creación". En las artes vivas, se hablara por ejemplo de "creación escénica"; y seguido se pensara esta "creación" como teniendo lugar "ante el espectador". Pero nada asegura que se trate realmente de eso. Al menos vale la pena lanzar un doble interrogación. Por un lado: para producir un obra, ¿a poco el artista trabaja con lo que no existía antes? Por otra lado: lo que con la obra ocurre; ¿ocurre "ante" o bien "con" el espectador?
Retomando "Instrucciones para convertirse"
Authors: Schneider Rebecca 
Published: December 2019

Este ensayo analiza una serie de performance fotográficos de Emilio Rojas titulada Instrucciones para convertirse (2019). La serie de Rojas rinde homenaje a la artista Laura Aguilar y, pensando en el homenaje, este ensayo considera el gesto, así como al llamado y la respuesta, como técnicas de performance, mediante las cuales los cuerpos y las obras de arte saltan cuerpo a cuerpo, miembro a miembro. A través de otra obra de Rojas, Heridas Abiertas (A Gloria), el ensayo luego se mueve para discutir la obra Fringe, de la artista anishnaabe Rebecca Belmore, que se puede leer junto a la amalgama Rojas/Aguilar. La aparición de Belmore en el capítulo marca el comienzo de un trabajo que hace gestos hacia mundos ancestrales, en su caso indígenas, para presentar alternativas a la marcha miope de los registros del tiempo capital-colonial. Acto seguido, hago un contrapunto entre Viaje a Italia, de Roberto Rossellini, y lsa obras de Belmore, Aguilar y Rojas. La película de Rossellini, así como los performances de Rojas, Aguilar y Belmore, exploran el salto de la gestualidad entre materiales animados e inanimados, entre materiales humanos y no humanos, como son las estatuas de piedra y la carne humana o, en el caso de Rojas, las extremidades de los árboles y las extremidades humanas. El esfuerzo, en todo el ensayos, es producir una práctica de críticismo de performance decolonial.
Association between heart rate response during orthostatic test and falls in polymorbid patients aged 60 years and older
Authors: Turusheva A. V. , Kotovskaya Yu. V. , Frolova E. V. 
Published: December 2019

Background. Orthostatic hypotension is a significant risk factor of falling in older adults. To diagnose the orthostatic hypotension an orthostatic test is used with assessment of heart rate (HR) response, systolic (SBP) and diastolic blood pressure (DBP) at the 3rd minute after the rise. However, according to studies, measurement of SBP and DBP at the 1st minute after rising can be more sensitive to detect older adults at risk of falling than at 3rd minute.Objective. The purpose of this study was to evaluate the role of changes in SBP, DBP and HR at the 1st, 2nd and 3rd minutes when performing an orthostatic test for identification of the elderly at high-risk of falls.Design and methods. This cross-sectional study included 100 adults aged 59+. Among them women comprise 56 % (n = 56). The following procedures were performed: the orthostatic test, anthropometry, medical history, assessment of drug treatment, depression evaluation, dementia and the degree of autonomy decline.Results. HR response at the 1st minute after the transition from horizontal to vertical position is more significant factor of falls risk than SBP and DBP changes during performing of orthostatic test. Absence of HR increasing during the transition from horizontal to vertical position associates with 10‑fold of risk falls among older adults: odds ratio 95 % confidence interval (OR 95 % CI) 10,5 (2,9–37,8). This association remained significant even after adjusting for age, gender, β-blockers use and comorbidity.Conclusion. Absence of HR increasing during the transition from horizontal to vertical position is a high sensitive marker of detecting older adults with polymorbidity in patients with the high risk of falls.
E^5_2 Yarı-Öklid Uzayındaki Biharmonik Hiperyüzeyler
Authors: Yeğin Şen Rüya 
Published: December 2019

Bu çalışmada, $\mathbb E^5_2$ yarı-Öklid uzayının indisi 2 olan biharmonik hiperyüzeyleri, $\nabla H$ gradyenti ışıksal olan $H$ ortalama eğriliğine sahip olmaları, yani $\left\langle \nabla H,\nabla H\right\rangle = 0$ ve $\nabla H\neq0$ koşullarının sağlanması varsayımı altında incelenmiştir. İlk iki bölümde problem tanıtılmış ve çalışmanın diğer bölümünde kullanılacak bazı temel tanım ve formüller hatırlatılmıştır. Ayrıca, $2$ indisli bir hiperyüzeyin şekil operatörlerinin tüm mümkün kanonik formları elde edilmiştir. Çalışmanın üçüncü bölümünde, bu durumların her biri için hiperyüzeylerin bazı geometrik özellikleri araştırılmıştır. Özellikle, $\nabla H$ gradyenti ışıksal olan biharmonik hiperyüzeyin şekil operatörünün $2$ olası kanonik formu olduğu elde edilmiştir. Hemen ardından, $\mathbb E^5_2$ yarı-Öklid uzayında indisi $2$ ve ortalama eğriliğinin gradyenti ışıksal olan bir biharmonik hiperyüzeyin olmadığı ispatlanmıştır. Son bölümdeise, çalışmadan elde edilen sonuçlar özetlenmiş ve tartışma bölümü verilmiştir.
Telenursing Using SKEDit To Educate Parents with Thalassemia Children
Authors: Andodo Candra , Haryanti Fitri , Widyandana Widyandana 
Published: December 2019

<p>Background: Excess iron levels and low hemoglobin (Hb) levels are one of the complications of Beta-Thalassemia. The implementation of education using <em>WhatsApp</em> is expected to increase parental knowledge of the illness and children to adhere to iron chelation therapy.</p><p> </p><p>Objective: To identify the effect of the implementation of education using <em>WhatsApp</em> through the SKEDit application compared to using booklets on parental knowledge and medication adherence in pediatric patients with thalassemia.</p><p> </p><p>Method: The study was quasi-experimental using pre and post-test with control group. The total sample was 61 respondents with purposive sampling technique. Parental knowledge was measured using a Parental knowledge about Thalassemia questionnaire and the level of adherence was measured using an indirect method known as 'Pill Count'. The data were then analyzed using the Mann whitney and wilcoxon test.</p><p> </p><p>Results: There was a significant difference in the level of knowledge in the pretest and posttest on the intervention group (p: 0.001) and the pretest and posttest in the control group (p: 0.001). There was a significant difference in the level of adherence of the pretest and posttest in the intervention group (p: 0.028). There was no significant difference in the level of adherence of the pretest and posttest in the control group (p: 0.214). There was no difference in the level of knowledge between the two groups (p: 0.994). There was no difference in the level of adherence between the two groups (p: 0.987).</p><p> </p><p>Conclusion: Providing education using WhatsApp through the SKEDit application and also booklets both effectively increase the level of parental knowledge and medication adherence of pediatric patients with thalassemia.</p>
The bioactive contents and antioxidant activity of honey bee nest extract of Apis dorsata Binghami from the North Sulawesi
Authors: Semuel Mokosuli Yermia , Kaunang Eva Sherly Nonke , Manopo Jacklin Stella 
Published: December 2019

Apis dorsata Binghami is a Sulawesi endemic honey bee. Apis dorsata Binghami cannot be bred, so it still lives wildlyin the forests of Sulawesi. However, Apis dorsata Binghami produces more honey, compared to all honey bee species. Furthermore, the diversity of plants as a source of nectar, pollen and plant resin, which is used in the formation of nests and honey is more, than all types of honey bees in the world. Ethnomedically, the Minahasa community has long used honeynest for degenerative diseases such as hyperlipidemia and cancer. Nevertheless, there have been no research reports on bioactive content and bioactivity of Apis dorsataBinghami nest extract. This research wasaimed to determinethe bioactive content of honey bee nest and to obtain the inhibitory concentration 50 (IC50) antioxidant activity of honey bee nest extractofApis dorsata Binghami. Honey bee nest was obtained directly from the forest of Minahasa peninsula, North Sulawesi, Indonesia. Extraction of fresh honey bee nest was conductedusingmaceration method. Bioactive content analysis was carried out by the Harborne method, followed by analysis using UV Vis spectrophotometer and High performance liquid chromatography. IC50antioxidant activity of honey bee nest extract was obtained using DPPH free radical reduction method. The results showed that Apis dorsata Binghami honey bee nest extract containedalkaloids, flavonoids, saponins, tannins, steroids and triterpenoids. Identified flavonoids displayed the highest phytochemical content. Based on the results of HPLC and UV Vis spectrophotometer analysis, there were 20 flavonoid derivatives found in honey bee nest samples in Minahasa. Ethanol extract and n-hexane extract showed high free radical reduction activity compared to vitamin C as a control treatment. However, ethanol extract produced the highest DPPH free radical reduction activity.
The Impact of Socioeconomic Status on Outcomes in Orthopaedic Surgery
Authors: Li Xinning , Galvin Joseph W. , Li Chris , Agrawal Ravi , Curry Emily J. 
Published: December 2019

➢Social determinants of healthis considered an umbrella term that includes factors such as education level, income and occupation, social class, social status, race, ethnicity, and sex.➢ Socioeconomic status (SES) is a fundamental cause of health-care disparities and is a critical issue affecting all fields of medicine. In orthopaedic surgery, the quality of care provided, whether by surgical intervention or nonoperative treatment, is closely intertwined with social factors related to the SES of a patient.➢ SES is a known predictor of morbidity and mortality within different orthopaedic subspecialties, and modifiable factors contributing to low SES must be evaluated and optimized to reduce health-care disparities.➢ With the emergence of value-based health care and solutions seeking to improve outcomes and reduce cost, progress is being made toward reducing negative surgical outcome predictors associated with SES.➢ With the transition from fee-for-service models to alternate payment models based on practice-specific quality data, identification and risk adjustment based on SES variables will be critical to prevent patient exclusion, delay in care, and misrepresentation of a surgeon’s relative performance based on patient-reported outcomes.
Quo Vadis Legal Protection of Traditional Batik Copyrights in Indonesia Local Government
Authors: Arifin Zainal , Hasyim Mochammad Wachid 
Published: December 2019

This research is motivated by the existence of philosophical, juridical and theoretical problems. Philosophically batik must be protected, because it is a unique work created by creative individuals. Juridical problems are unclear rules about traditional batik. The theoretical problem is between das sein and das solen, it should theoretically be that all traditional batik motifs from the creativity of residents in Kediri City must be registered as the copyright of each craftsman. But in reality, the craftsmen have not registered their work with the Ministry of Law and Human Rights of the Republic of Indonesia to obtain a copyright license. So that the craftsmen have yet to get the legal protection of the batik copyright they created. The issues raised are (1) How to carry out the legal protection of traditional batik art copyrights in the City of Kediri and (2) the factors that hinder traditional batik craftsmen in Kediri City do not take care of their copyright. This study uses empirical research methods with a sociological juridical approach. From the research, it was found that the legal protection of batik batik copyright in Kediri was done by registering the copyright and the traditional batik brand rights. While the factor that hinders the batik craftsmen from registering their copyright is the lack of awareness of traditional batik craftsmen about copyright, the process of obtaining a copyright that is considered not easy and requires a high cost.
Resveratrol inhibits high glucose-induced activation and cytokine production of isolated primary pancreatic stellate cells
Authors: Zhou Zhen , Sun Xiaodong , Yan Rao , An Jinfeng , Zhou Xinjian , Li Mingyi , Gu Xinsheng , Hao Xincai , Sang Ming 
Published: December 2019

Objective: Activation of pancreatic stellate cells (PSCs) is detrimental to pancreas function by promoting pancreatic fibrosis. Resveratrol is a natural and pharmacologically active compound. This study is to investigate the effect of resveratrol on the bilogical behavior of PSCs under high glucose condition.Methods: Isolated primary mouse PSCs were cultured in low glucose ( 5.5 mmol/L glucose, LG group ) medium, high glucose ( 25 mmol/L glucose, HG group ) medium and treated with resveratrol ( 25 μmol/L or 50 μmol/L). Cell proliferation was examined using MTT assay. The expression of α-SMA and collagen I were determined using Western blotting. Alpha-SMA expression was also determined using immunocytochemistry staining. IL-1, IL-6, and TNF-α mRNA levels and secretion levels in media of PSCs were determined using qRT-PCR and ELISA respectively.Results: Cell Proliferation, α-SMA and collagen I expression levels, IL-1, IL-6, and TNF-α mRNA levels and secretion levels of PSCs were increased after high glucose treatment, compared with low glucose treatment. They were significantly decreased in PSCs treated with both high glucose and resveratrol, compared with high glucose treatment.Conclusion: Resveratrol inhibited high glucose induced PSCs proliferation, activation，cytokine expression and secretion in PSCs. Therefore, resveratrol can be potentially used in therapy of diseases such as type 2 diabetes mellitus (T2DM), pancreatitis and pancreatic cancer where PSCs is activated by high glucose.
The Trend Analysis and Quality Evaluation of Live Attenuated Yellow Fever Vaccine in China from 2011 to 2018
Authors: Wang Ling , Liu Jingjing , Kong Yan , Li Yuhua 
Published: December 2019

To summarize the lot release of live attenuated yellow fever vaccine in China during 2011-2018 and evaluate the total quality as well as problem in quality control of the vaccine. By reviewing the data and laboratory test，34 batches of live attenuated yellow fever vaccine were determined for virus titer according to the standard for license, of which 52 batches were determined for ovalbumin residue by ELISA, and 14 batches for moisture. The determination results were subjected to statistical and quality trend analyses, and compared with those by the manufacturers，based on which the general status of vaccine quality was reviewed. All the determination results of virus titer, ovalbumin residue and moisture met the requirements in Chinese Pharmacopoeia, and there is no difference in those by the manufacturers and those by the National Institutes for Food and Drug Control . The quality of live attenuated yellow fever vaccine was stable, which met the requirements in Chinese Pharmacopoeia. The implementation of lot release, batch inspection and trend analysis may effectively regulate and supervise the vaccine production．
A randomized controlled trial study of the acceptability, feasibility, and preliminary impact of SITA (SMS as an Incentive To Adhere): A mobile technology-based intervention informed by behavioral economics to improve ART adherence among youth in Uganda
Authors: MacCarthy Sarah , Wagner Zachary , Mendoza-Graf Alexandra , Gutierrez Carlos Ignacio , Samba Clare , Birungi Josephine , Okoboi Stephen , Linnemayr Sebastian 
Published: December 2019

Abstract
Background: Studies report serious adherence problems among youth (individuals age 15 to 24 years of age) in Uganda. Recent growth in mobile phone ownership has highlighted the potential of using text-based interventions to improve antiretroviral treatment (ART) adherence among Ugandan youth. We piloted a randomized controlled trial of a text-based intervention providing weekly real-time antiretroviral adherence feedback, based on information from a smart pill box, to HIV-positive Ugandan youth. In this paper, we report the acceptability, feasibility, and preliminary impact of the intervention.
Methods: We randomized participants to a control group, or to receive messages with information on either their own adherence levels (Treatment 1 - T1), or their own adherence and peer adherence levels (Treatment 2 – T2). We conducted six focus groups with providers and youth ages 15-24, double coded 130 excerpts, and achieved a pooled Cohen’s Kappa of 0.79 and 0.80 based on 34 randomly selected excerpts.
Result: The quantitative and qualitative data show that the intervention was deemed acceptable and feasible. After controlling for baseline adherence, the T1 group had 3.8 percentage point lower adherence than the control group (95% CI -9.9, 2.3) and the T2 group had 2.4 percentage points higher adherence than the control group (95% CI -3.0, 7.9). However, the average effect masks an increasing treatment effect over time for the T2 group; a 2.5 percentage point increase in the initial 9-weeks that grows steadily to 9.0 percentage points by the last 9-weeks of the study. We find negative treatment effects for T1 in 3 of the 4 9-week intervals. This pilot study was not designed to detect statistically significant differences.
Conclusions: Improving youth’s adherence by supplementing information about their adherence with information about adherence of peers is a promising new strategy that should be further evaluated in a fully-powered study. Providing one’s own adherence information alone appears to have less potential.
Variation in plastid genomes in the gynodioecious species Silene vulgaris
Authors: Krüger Manuela , Abeyawardana Oushadee A.J. , Juricek Miloslav , Krüger Claudia , Storchova Helena 
Published: December 2019

Abstract
Background
Gynodioecious species exist in two sexes – male-sterile females and hermaphrodites. Male sterility in higher plants often results from mitonuclear interaction between the CMS (cytoplasmic male sterility) gene(s) encoded by mitochondrial genome and by nuclear-encoded restorer genes. Mitochondrial and nuclear-encoded transcriptomes in females and hermaphrodites are intensively studied, but little is known about sex-specific gene expression in plastids. We have compared plastid transcriptomes between females and hermaphrodites in two haplotypes of a gynodioecious species Silene vulgaris with known CMS candidate genes.
Results
We generated complete plastid genome sequences from five haplotypes S. vulgaris including the haplotypes KRA and KOV, for which complete mitochondrial genome sequences were already published. We constructed a phylogenetic tree based on plastid sequences of S. vulgaris. Whereas lowland S. vulgaris haplotypes including KRA and KOV clustered together, the accessions from high European mountains diverged early in the phylogram. S. vulgaris belongs among Silene species with slowly evolving plastid genomes, but we still detected 212 substitutions and 112 indels between two accessions of this species. We estimated elevated Ka/Ks in the ndhF gene, which may reflect the adaptation of S. vulgaris to high altitudes, or relaxed selection. We compared depth of coverage and editing rates between female and hermaphrodite plastid transcriptomes and found no significant differences between the two sexes. We identified 51 unique C to U editing sites in the plastid genomes of S. vulgaris, 38 of them in protein coding regions, 2 in introns, and 11 in intergenic regions. The editing site in the psbZ gene was edited only in one of two plastid genomes under study.
Conclusions
We revealed no significant differences between the sexes in plastid transcriptomes of two haplotypes of S. vulgaris. It suggests that gene expression of plastid genes is not affected by CMS in flower buds of S. vulgaris, although both sexes may still differ in plastid gene expression in specific tissues. We revealed the difference between the plastid transcriptomes of two S. vulgaris haplotypes in editing rate and in the coverage of several antisense transcripts. Our results document the variation in plastid genomes and transcriptomes in S. vulgaris.