bluuebunny/crossref_metadata_2025_split huggingface dataset:
Update of the BEVQ‐15, a beverage intake questionnaire for habitual beverage intake for adults: determining comparative validity and reproducibility
Authors: Fausnacht A. G. , Myers E. A. , Hess E. L. , Davy B. M. , Hedrick V. E. 
Published: April 2020

AbstractIntroductionThe BEVQ‐15 is a beverage intake questionnaire that estimates the habitual average daily intake of 15 beverage categories (kcal and fl oz), as well as total sugar‐sweetened beverages (SSB) and total beverages. However, subsequent to its initial validation in 2010, it has not been updated. The present study aimed to assess the convergent validity and reproducibility of the updated form of the BEVQ‐15 to better reflect current beverage consumption trends.MethodsThe study population included adults (n = 50) aged ≥18 years, recruited from a local university community. Participation consisted of three laboratory visits within a 4‐week period in which the updated BEVQ‐15 was administered during the first and last visit and four 24‐h dietary recalls were collected. BEVQ‐15 modifications included removing limits of 60 fl oz per beverage, adding a nut milk category, and providing creamer and sweetener preferences for coffee/tea categories. Convergent validity was assessed by comparing reported beverage intake between the BEVQ‐15 and dietary recalls. Reproducibility was assessed by comparing both BEVQ‐15 administrations. Analyses included descriptive statistics, Wilcoxon signed rank tests, Bland–Altman plots and Spearman's correlations.ResultsFor validity, Bland–Altman plot agreement between the BEVQ‐15 and recalls was in the range 92–96% for total SSB and total beverage intake. For reproducibility, all beverage categories, total SSB, and total beverage intake were significantly correlated between the two BEVQ‐15 administrations (r = 0.41–0.85; P ≤ 0.01).ConclusionsThis updated version of the BEVQ‐15 demonstrated moderate convergent validity and reproducibility for total beverage consumption among well‐educated southwest Virginia adults.
Monitoring domestic material consumption at lower territorial levels: A novel data downscaling method
Authors: Bianchi Marco , Tapia Carlos , del Valle Ikerne 
Published: April 2020

AbstractThe availability of harmonized and granular information is critical for the design of place‐sensitive policies toward more sustainable economies. However, accessibility to disaggregated data at subnational levels remains an exception in many geographies and policy domains. In this article, we develop a novel three‐stage—specification, optimization, extrapolation (SOE)—econometric approach to infer harmonized regional level estimates from broadly available socioeconomic data. The approach is tested by estimating domestic material consumption (DMC) in more than 280 European regions (at NUTS 2 level). Unlike previous methods based on similar econometric techniques, our method makes explicit the socio‐metabolic profiles of subnational territories by estimating and applying country‐specific elasticities. Our DMC estimates are consistent with those obtained by ad hoc material flow studies that could be accessed for a sample of regions. The SOE method presented in this paper provides decision‐makers with a powerful tool to explore socio‐metabolic profiles at subnational level and therefore to understand the potential effects of policies aimed at supporting circular economy transitions at such levels. The method can also be adapted with relative ease to support policy designs in other policy areas challenged by severe data scarcity.
Experimental and theoretical studies of frequency response function of dagger‐shaped atomic force microscope cantilever in different immersion environments
Authors: GHOLIZADEH PASHA A.H. , SADEGHI A. 
Published: April 2020

SummaryIn this study, the amplitude of frequency response functions of vertical and rotational displacements and resonant frequency of a dagger‐shaped atomic force microscope cantilever have been investigated. To increase the accuracy of theoretical model, all necessary details for cantilever and sample surface have been taken into account. In this paper, carbon tetrachloride (CCL4), methanol, acetone, water and air have been considered as the environments. In the most cases, presence and absence of tip–sample interaction force have studied. For a sample cantilever immersed in air, both of the Euler–Bernoulli and Timoshenko beam theories have been compared. The results indicate that the tip–sample interaction force raises the resonant frequency. Increasing the liquid viscosity leads to a decrease in the resonant frequency and the amplitude of frequency response functions of vertical and rotational displacements. Increasing the rectangular and tapered parts lengths, decreases the resonant frequency and amplitude of frequency response functions of vertical and rotational displacements. By increasing the cantilever thickness the resonant frequency and amplitude of frequency response functions of vertical and rotational displacements increases. Theoretical model for air and water has been compared with experimental work. Results show good agreement.
Hyperuricemia is associated with androgenetic alopecia in men: A cross‐sectional case‐control study
Authors: Ma Jingwen , Sheng Youyu , Lao Zhengyin , Zhao Jun , Yang Qinping 
Published: April 2020

AbstractBackgroundEarly androgenetic alopecia (AGA) is patterned hair loss occurring before 30 years. Early AGA is frequently reported in men and carries the risk of obesity, metabolic syndrome, and cardiovascular diseases. Hyperuricemia used to be a minor component of metabolic syndrome. Recently, increasing number of studies has proved that hyperuricemia is an independent risk factor for many cardiovascular diseases and psoriasis. However, none of these studies have examined the relationship between hyperuricemia and AGA.AimsTo determine the association between hyperuricemia and AGA in men.MethodsA cross‐sectional case‐control study was conducted. The medical charts and photographs of men with a clinical diagnosis of AGA were reviewed. The clinical and laboratory data of AGA and control groups were compared.ResultsMen with AGA (n = 1312) had higher mean uric acid level (6.25 mg/dL vs 5.97 mg/dL; P < .001) and higher prevalence of hyperuricemia (25.0% vs 15.6%; P < .001) than those without AGA (n = 2624). There was no statistically significant association between AGA severity and hyperuricemia (P = .295).ConclusionsMen with early AGA have a higher prevalence of hyperuricemia.
Successful pregnancy and vaginal delivery after laparoscopic excision of a congenital uterine cervical diverticulum: A case report
Authors: Tanaka Keiko , Shiga Naomi , Kuno Takashi , Watanabe Zen , Tachibana Masahito , Yaegashi Nobuo 
Published: April 2020

AbstractUterine cervical diverticulum is a very rare malformation. Affected patients are reported to have infertility issues and problems during the perinatal period. A 32‐year‐old nulliparous woman visited another obstetrics and gynecology hospital because of infertility. A cyst branching out from the uterine cervix was discovered. Subsequently, she conceived via assisted reproductive technology, but the uterine cyst was left untreated. Eventually, the pregnancy was terminated due to an enlarged uterine cyst and several birth defects. She was referred to our hospital where she was diagnosed with a uterine cervical diverticulum. We excised the diverticulum via a laparoscopic approach. Afterward, she became pregnant and delivered a baby vaginally at 37 weeks. To our knowledge, this is the first report of successful delivery after laparoscopic diverticulum excision. We recommend cervical diverticulum excision before pregnancy because of the potential adverse events associated with cervical diverticulum during pregnancy.
Effects of Heat Waves and Light Deprivation on Giant Kelp Juveniles (Macrocystis pyrifera, Laminariales, Phaeophyceae)
Authors: Sánchez‐Barredo Mariana , Sandoval‐Gil Jose Miguel , Zertuche‐González Jose Antonio , Ladah Lydia B. , Belando‐Torrentes María Dolores , Beas‐Luna Rodrigo , Cabello‐Pasini Alejandro 
Published: April 2020

Due to climate change, the incidence of marine heat waves (MHWs) has increased, yet their effects on seaweeds are still not well understood. Adult sporophytes ofMacrocystis pyrifera, the species forming the iconic giant kelp forests, can be negatively affected by thermal stress and associated environmental factors (e.g., nutrient depletion, light deprivation); however, little is known about the tolerance/vulnerability of juvenile sporophytes. Simultaneously toMHWs, juveniles can be subjected to light limitation for extended periods of time (days–weeks) due to factors causing turbidity, or even because of shading by understory canopy‐forming seaweeds. This study evaluated the effects of a simulatedMHW(24°C, 7 d) in combination (or not) with light deprivation, on the photosynthetic capacities, nutrient uptake, and tissue composition, as well as oxidative stress descriptors ofM. pyriferajuvenile sporophytes (single blade stage, up to 20 cm length). Maximum quantum yield (Fv/Fm) decreased in juveniles under light at 24°C, likely reflecting some damage on the photosynthetic apparatus or dynamic photoinhibition; however, no other sign of physiological alteration was found in this treatment (i.e., pigments, nutrient reserves and uptake, oxidative stress). Photosynthetic capacities were maintained or even enhanced in plants under light deprivation, likely supported by photoacclimation (pigments increment); by contrast, nitrate uptake and internal storage of carbohydrates were strongly reduced, regardless of temperature. This study indicated that light limitation can be more detrimental to juvenile survival, and therefore recruitment success ofM. pyriferaforests, than episodic thermal stress fromMHWs.
Exploding head syndrome, chronotype, parasomnias and mental health in young adults
Authors: Kirwan Emma , Fortune Donal G. 
Published: April 2020

AbstractAlthough inadequate sleep among young people is well documented in the literature, anomalous sleep experiences, such as the parasomnia termed exploding head syndrome (EHS), have received little empirical attention. The current study examined the association of sleep quality, symptoms of psychological distress and other unusual sleep experiences with EHS in a sample of young adults (n = 135, age M = 21.77, SD = 2.08). We also aimed to account for the possible effect of participant chronotype on sleep experiences. The lifetime prevalence of EHS among participants was 20.0%. Three‐quarters (75.6%) of participants reported poor quality sleep according to the Pittsburgh Sleep Quality Index (PSQI). Univariate analysis showed that participants with a lifetime prevalence of EHS experienced more symptoms of anxiety and poorer sleep quality; age, gender and symptoms of depression were not significantly related to EHS. Parasomnias (OR [95% CI] = 1.62 [1.02–2.57], p = .040) and action‐related sleep disorders (OR [95% CI] = 1.87 [1.09–3.20], p = .023) were associated with lifetime experience of EHS in a logistic regression analysis. Chronotype did not significantly impact mood, sleep quality or presence of EHS. Results suggest that EHS is more common in young people than previously considered and ought to be examined in conjunction with the presence of other unusual sleep disorders. This study provides valuable insight into young peoples' sleep experiences and key factors associated with EHS.
Evaluation of novel serological markers and autoantibodies in dogs with inflammatory bowel disease
Authors: Estruch Juan J. , Barken Derren , Bennett Nicole , Krawiec Donald K. , Ogilvie Gregory K. , Powers Barbara E. , Polansky Benjamin J. , Sueda Michael T. 
Published: April 2020

AbstractBackgroundThe use of serological markers to diagnose inflammatory bowel disease (IBD) in humans is well‐established. Because of the frequency of IBD in dogs and resources required for its diagnosis with current methods, new approaches are desired.ObjectiveThe goal is to evaluate novel serologic markers to differentiate clinical cohorts in dogs with gastrointestinal (GI) disease and assess their potential to develop a serum‐based IBD diagnostic test.AnimalsSeventy dogs diagnosed with biopsy‐confirmed IBD, 23 dogs with non‐IBD predominantly acute GI diseases, and 58 normal dogs.MethodsProspective control study. ELISA methods were developed to detect autoantibodies to polymorphonuclear leukocytes (APMNA) and calprotectin (ACNA), antibodies against gliadins (AGA), microbial outer membrane porin C (ACA), and flagellins (AFA) isolated from diseased dogs based on clinical and histopathological scoring.ResultsIBD dogs displayed a 39%‐76% prevalence of seropositivity against selected serologic markers that markedly decreased to 0%‐13% in non‐IBD and normal dogs. ROC analysis showed statistical significance in differentiating the cohorts, with seropositivity against OmpC being the highest single performance marker. The combination of markers such as OmpC and APMNA reached specificities of 93%‐99% and 79%‐98% and sensitivities of 76%‐97% and 66%‐86% when comparing IBD versus normal cohorts and non‐IBD cohorts, respectively.Conclusion and Clinical ImportanceSeropositivity of canine immunoglobulins A against selected serologic markers in dogs appears promising in the detection and differentiation of IBD versus other acute GI conditions. Among them, antibody reactivity to Escherichia coli OmpC and canine autoantibodies against polymorphonuclear leukocytes displayed the highest single marker discriminating performance.
Gut microbial diversity across a contact zone for California voles: Implications for lineage divergence of hosts and mitonuclear mismatch in the assembly of the mammalian gut microbiome
Authors: Lin Dana , Lacey Eileen A. , Bach Bryan H. , Bi Ke , Conroy Christopher J. , Suvorov Anton , Bowie Rauri C. K. 
Published: April 2020

AbstractGut microbial diversity is thought to reflect the co‐evolution of microbes and their hosts as well as current host‐specific attributes such as genetic background and environmental setting. To explore interactions among these parameters, we characterized variation in gut microbiome composition of California voles (Microtus californicus) across a contact zone between two recently diverged lineages of this species. Because this contact zone contains individuals with mismatched mitochondrial‐nuclear genomes (cybrids), it provides an important opportunity to explore how different components of the genotype contribute to gut microbial diversity. Analyses of bacterial 16S rRNA sequences and joint species distribution modelling revealed that host genotypes and genetic differentiation among host populations together explained more than 50% of microbial community variation across our sampling transect. The ranked importance (most to least) of factors contributing to gut microbial diversity in our study populations were: genome‐wide population differentiation, local environmental conditions, and host genotypes. However, differences in microbial communities among vole populations (β‐diversity) did not follow patterns of lineage divergence (i.e., phylosymbiosis). Instead, among‐population variation was best explained by the spatial distribution of hosts, as expected if the environment is a primary source of gut microbial diversity (i.e., dispersal limitation hypothesis). Across the contact zone, several bacterial taxa differed in relative abundance between the two parental lineages as well as among individuals with mismatched mitochondrial and nuclear genomes. Thus, genetic divergence among host lineages and mitonuclear genomic mismatches may also contribute to microbial diversity by altering interactions between host genomes and gut microbiota (i.e., hologenome speciation hypothesis).
Proton‐pump inhibitor use and the development of new ischemic heart disease in non‐cardiac chest pain patients
Authors: Kim Yeseong , Ganocy Stephen , Fass Ronnie 
Published: April 2020

AbstractBackgroundThe growing reports regarding cardiac‐related adverse events of chronic proton‐pump inhibitors (PPI) treatment, a mainstay therapy of non‐cardiac chest pain (NCCP), have raised concerns about alteration of the natural course in NCCP patients using PPI. We aimed to determine if NCCP patients receiving PPI have a higher risk of developing ischemic heart disease (IHD) compared to those not receiving PPI therapy.MethodsThree groups of NCCP patients were included; PPI, histamine‐2 receptor antagonist (H2RA), and no antireflux treatment. Diagnosis of NCCP had to precede diagnosis of IHD by at least 30 days, and in those receiving antireflux treatment at 30 days after starting the medication. Data analysis was corrected for 6 known confounding factors for IHD including hyperlipidemia, hypertension, obesity, smoking status, male gender, and diabetes mellitus.Key ResultsOf the patients on PPI or H2RA, 1280 and 250, respectively, developed IHD. Patients on PPI therapy displayed an increased odd of developing ischemic heart disease compared to patients never placed on therapy (OR 1.14, 95% CI 1.03‐1.25, P‐value .0093). Patients placed on H2RA therapy did not show a statistically significant change in risk compared to patients who were not placed on therapy (OR 0.90, 95% CI 0.77‐1.06, P‐value .2049). Number needed to harm in the PPI and H2RA groups was 17 and 45, respectively.ConclusionsPPIs confer a statistically significant, but marginal effect on the risk of IHD development in NCCP patients. Thus, PPI use in NCCP only minimally alters the overall benign natural course of the disease.
Clinical presentation and characteristics of pelvic floor myofascial pain in patients presenting with constipation
Authors: Liu Andy , Chedid Victor , Wang Xiao J. , Vijayvargiya Priya , Camilleri Michael 
Published: April 2020

AbstractBackgroundPatients with pelvic floor myofascial pain (PFMP) have puborectalis tenderness on digital rectal examination (DRE). Little is known about its significance to anorectal function in patients presenting with constipation.AimTo characterize demographics, clinical characteristics, findings on anorectal manometry (ARM), diagnosis of rectal evacuation disorder (RED), colonic transit [normal (NTC) or slow (STC)], and imaging in constipated patients with PFMP and compare these features to constipation without PFMP.MethodsWe performed an electronic medical records review of patients with constipation evaluated by a single gastroenterologist between January 2008 and February 2019. Patients with PFMP were compared to controls with constipation but without PFMP (1:2 ratio).Key ResultsA total of 98 PFMP cases and 196 controls were identified. Constipated patients with PFMP were more likely to have RED [OR 7.59 (3.82‐15.09), P < .01]; controls were more likely to have either NTC [OR 4.25 (1.45‐12.42), P < .01] or STC [OR 3.57 (1.45‐8.78), P < .01]. RED in patients with PFMP is supported by comparison to controls: On DRE, they had increased resting tone [OR 2.25 (1.33‐3.83), P < .01] and paradoxical contraction of the puborectalis upon simulated evacuation [OR 3.41 (1.94‐6.00), P < .01]; on ARM, they had higher maximum resting pressure (102.9 mmHg vs 90.7 mmHg, P < .01) and lower rectoanal pressure gradient (−39.4 mmHg vs −24.7 mmHg, P < .01).Conclusions/InferencesIn constipated patients, PFMP is highly associated with RED. Its presence provides a valuable clue regarding the etiology of a patient's constipation; it should be assessed in all patients with constipation and should also be an additional target for management.
Characterization of the colonic response to bisacodyl in children with treatment‐refractory constipation
Authors: Heitmann Paul T. , Wiklendt Lukasz , Thapar Nikhil , Borrelli Osvaldo , Di Lorenzo Carlo , Yacob Desalegn T. , Baaleman Desiree F. , Vriesman Mana H. , Nurko Samuel , El‐Chammas Khalil , Kaul Ajay , Benninga Marc A. , Koppen Ilan J.N. , Wattchow David A. , Brookes Simon J.H. , Dinning Phil G. 
Published: April 2020

AbstractBackgroundColonic manometry with intraluminal bisacodyl infusion can be used to assess colonic neuromuscular function in children with treatment‐refractory constipation. If bisacodyl does not induce high‐amplitude propagating contractions (HAPCs), this can be an indication for surgical intervention. A detailed characterization of the colonic response to intraluminal bisacodyl in children with constipation may help to inform clinical interpretation of colonic manometry studies.MethodsStudies were performed in five pediatric hospitals. Analysis included identification of HAPCs, reporting HAPCs characteristics, and an area under the curve (AUC) analysis. Comparisons were performed between hospitals, catheter type, placement techniques, and site of bisacodyl infusion.ResultsOne hundred and sixty‐five children were included (median age 10, range 1‐17 years; n = 96 girls). One thousand eight hundred and ninety‐three HAPCs were identified in 154 children (12.3 ± 8.8 HAPCs per child, 0.32 ± 0.21 HAPCs per min; amplitude 113.6 ± 31.5 mm Hg; velocity 8.6 ± 3.8 mm/s, propagation length 368 ± 175 mm). The mean time to first HAPC following bisacodyl was 553 ± 669 s. Prior to the first HAPC, there was no change in AUC when comparing pre‐ vs post‐bisacodyl (Z = −0.53,P = .60). The majority of HAPCs terminated in a synchronous pressurization in the rectosigmoid. Defecation was associated with HAPCs (χ2(1)=7.04,P < .01). Site of bisacodyl administration, catheter type, and hospital location did not alter the response.Conclusions and InferencesIntraluminal bisacodyl induced HAPCs in 93% of children with treatment‐refractory constipation. The bisacodyl response is characterized by ≥1 HAPC within 12 minutes of infusion. The majority of HAPCs terminate in a synchronous pressurization in the rectosigmoid. Optimal clinical management based upon colonic manometry findings is yet to be determined.
Needle‐Through‐Needle Technique in Lumbar Interlaminar Epidural Steroid Injection: A Case Report
Authors: Zhang Xiaolu Linda , Herzig Samuel , Gritsenko Karina , Hascalovici Jacob , Dua Simran , Shaparin Naum 
Published: April 2020

AbstractWhen performing lumbar epidural steroid injection on obese patients, needle placement can be challenging due to the difficulty in estimating the appropriate needle length to utilize. Often times, the standard 3.5‐inch Tuohy needle is too short to reach its target. In our case report, a needle‐through‐needle technique was attempted in a lumbar interlaminar epidural steroid injection procedure after the initial needle fell short of the epidural space. To avoid removing the initial needle and restarting the procedure using a longer needle, a 20‐gauge 6‐inch Tuohy needle was inserted into the 17‐gauge 3.5‐inch Tuohy needle, successfully reaching the epidural space. This technique can facilitate quicker needle placement by avoiding the need for restarting the procedure with a longer needle. Thus, procedural time and radiation exposure may be decreased, as may patient discomfort from repeat needle insertions.