bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colorectal cancers utilize glutamine as an anaplerotic substrate of the TCA cycle in vivo
Authors: Zhao Yiqing , Zhao Xuan , Chen Vanessa , Feng Ying , Wang Lan , Croniger Colleen , Conlon Ronald A. , Markowitz Sanford , Fearon Eric , Puchowicz Michelle , Brunengraber Henri , Hao Yujun , Wang Zhenghe 
Published: December 2019

AbstractCancer cells in culture rely on glutamine as an anaplerotic substrate to replenish tricarboxylic acid (TCA) cycle intermediates that have been consumed. but it is uncertain whether cancers in vivo depend on glutamine for anaplerosis. Here, following in vivo infusions of [13C5]-glutamine in mice bearing subcutaneous colon cancer xenografts, we showed substantial amounts of infused [13C5]-glutamine enters the TCA cycle in the tumors. Consistent with our prior observation that colorectal cancers (CRCs) with oncogenic mutations in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic (PIK3CA) subunit are more dependent on glutamine than CRCs with wild type PIK3CA, labeling from glutamine to most TCA cycle intermediates was higher in PIK3CA-mutant subcutaneous xenograft tumors than in wild type PIK3CA tumors. Moreover, using orthotopic mouse colon tumors estalished from human CRC cells or patient-derived xenografts, we demonstrated substantial amounts of infused [13C5]-glutamine enters the TCA cycle in the tumors and tumors utilize anaplerotic glutamine to a greater extent than adjacent normal colon tissues. Similar results were seen in spontaneous colon tumors arising in genetically engineered mice. Our studies provide compelling evidence CRCs utilizes glutamine to replenish the TCA cycle in vivo, suggesting that targeting glutamine metabolism could be a therapeutic approach for CRCs, especially for PIK3CA-mutant CRCs.
Effects of compound probiotics on the weight, immunity performance and fecal microbiota of forest musk deer
Authors: Liu Xu , Zhao Wei , Yu Dong , Cheng Jian-Guo , Luo Yan , Wang Yin , Yang Ze-Xiao , Yao Xue-Ping , Wu Shao-Shuai , Wang Wu-You , Yang Wei , Li Dan-Qin , Wu Yi-Ming 
Published: December 2019

AbstractProbiotics are intended to provide health benefits when consumed, generally by improving or restoring the gut flora. The health problems of forest musk deer (FMD, Moschus berezovskii), a threatened species currently under conservation, restrict the development of captive musk deer. This study was conducted with the aim of analyzing the effects of forest musk deer compound probiotics (FMDPs) on weight, immunity performance and fecal microbiota in FMD by measuring average daily weight gain (ADG) and immune-related factors and by using high-throughput 16S rRNA sequencing to investigate differences in the fecal microbiota among the control group (4 samples), treatment group A (4 samples) and treatment group B (4 samples). The results showed that the ADG of treatment groups A and B was significantly higher than that of the control group (p = 0.032, p = 0.018). The increase in IgA and IgG levels in treatment group B was significantly higher than that in the control group (p = 0.02, p = 0.011). At the phylum and genus levels, the difference in bacterial community structure was significant between treatment group B and the control group. Both the alpha diversity and beta diversity results showed significant differences in the microbiota of FMD before and after FMDP feeding. In summary, the results indicated that FMDPs could promote the growth of growing FMD, improve immunity and balance the role of intestinal microbes.
Quantitative background parenchymal enhancement to predict recurrence after neoadjuvant chemotherapy for breast cancer
Authors: Moliere Sebastien , Oddou Isabelle , Noblet Vincent , Veillon Francis , Mathelin Carole 
Published: December 2019

AbstractBreast background parenchymal enhancement (BPE) is an increasingly studied MRI parameter that reflects the microvasculature of normal breast tissue, which has been shown to change during neoadjuvant chemotherapy (NAC) for breast cancer. We aimed at evaluating the BPE in patients undergoing NAC and its prognostic value to predict recurrence. MRI BPE was visually and quantitatively evaluated before and after NAC in a retrospective cohort of 102 women with unilateral biopsy-proven invasive breast cancer. Pre-therapeutic BPE was not predictive of pathological response or recurrence. Quantitative post-therapeutic BPE was significantly decreased compared to pre-therapeutic value. Post-therapeutic quantitative BPE significantly predicted recurrence (HR = 6.38 (0.71, 12.06), p < 0.05).
Supplementation of live yeast based feed additive in early life promotes rumen microbial colonization and fibrolytic potential in lambs
Authors: Chaucheyras-Durand Frédérique , Ameilbonne Aurélie , Auffret Pauline , Bernard Mickaël , Mialon Marie-Madeleine , Dunière Lysiane , Forano Evelyne 
Published: December 2019

AbstractRumen microbiota is of paramount importance for ruminant digestion efficiency as the microbial fermentations supply the host animal with essential sources of energy and nitrogen. Early separation of newborns from the dam and distribution of artificial milk (Artificial Milking System or AMS) could impair rumen microbial colonization, which would not only affect rumen function but also have possible negative effects on hindgut homeostasis, and impact animal health and performance. In this study, we monitored microbial communities in the rumen and the feces of 16 lambs separated from their dams from 12 h of age and artificially fed with milk replacer and starter feed from d8, in absence or presence of a combination of the live yeast Saccharomyces cerevisiae CNCM I-1077 and selected yeast metabolites. Microbial groups and targeted bacterial species were quantified by qPCR and microbial diversity and composition were assessed by 16S rDNA amplicon sequencing in samples collected from birth to 2 months of age. The fibrolytic potential of the rumen microbiota was analyzed with a DNA microarray targeting genes coding for 8 glycoside hydrolase (GH) families. In Control lambs, poor establishment of fibrolytic communities was observed. Microbial composition shifted as the lambs aged. The live yeast supplement induced significant changes in relative abundances of a few bacterial OTUs across time in the rumen samples, among which some involved in crucial rumen function, and favored establishment of Trichostomatia and Neocallimastigaceae eukaryotic families. The supplemented lambs also harbored greater abundances in Fibrobacter succinogenes after weaning. Microarray data indicated that key cellulase and hemicellulase encoding-genes were present from early age in the rumen and that in the Supplemented lambs, a greater proportion of hemicellulase genes was present. Moreover, a higher proportion of GH genes from ciliate protozoa and fungi was found in the rumen of those animals. This yeast combination improved microbial colonization in the maturing rumen, with a potentially more specialized ecosystem towards efficient fiber degradation, which suggests a possible positive impact on lamb gut development and digestive efficiency.
Effects of a comprehensive intervention on hypertension control in Chinese employees working in universities based on mixed models
Authors: Li Yang , Xiaoqing Jin , Xinhua Tang , Xiaoling Shou , Xiaoling Xu , Wei Yu , Zengwu Wang , Xin Wang , Pinpin Zheng , Jing Yan 
Published: December 2019

AbstractWe conducted a comprehensive intensive intervention for hypertension patients working in universities or colleges. From July 2015 to March in 2016, 220 hypertension subjects were recruited, with 165 cases in intensive intervention group and 55 in standard intervention group. After 24 months of intervention, 208 ones including of 157 in intensive intervention group and 51 in standard intervention group were included in the final analysis. The patients in standard intervention group were given routine intervention, which mainly including of drug treatment and health education. The patients in intervention group were given comprehensive intensive intervention in addition to routine intervention, including follow-up management of hypertension, emotional, lifestyle intervention and else. The study and experimental protocols were approved by institutional review board of Zhejiang Hospital and Fu Wai Hospital and registered (ChiCTR-ECS-14004641, date of registration: May 8, 2014). After 2 years, compared with the standard intervention group, SBP/DBP in the intensive intervention group decreased by 3.7/4 mmHg and BP control rate increased by 8.9%, and the unhealthy behaviors and life quality including tension and pressure were also improved in the intensive intervention group. We used mixed effect model to analyze the intervention effect which could solve the problems of missing values and correlation. The intensive intervention of hypertension control including follow-up management, emotional and lifestyle intervention in occupational places could promote the development of the prevention, treatment and control of hypertension among staff in colleges and universities.
Predictive factors for the outcomes of Graves’ disease patients with radioactive iodine (131I) treatment
Authors: Xing Yu-Zhuo , Zhang Kun , Jin Gang 
Published: December 2019

Abstract
Although radioactive iodine (131I) treatment (RIT) is recommended as the preferred option for patients with Graves’ disease (GD), the predictive factors for its clinical outcomes are still unclear. In the present study, we aim to investigate the factors influencing the success rate of RIT treatment on primary GD with a calculated dose approach. The thyroid function (hyperthyroidism, euthyroidism or hypothyroidism) was evaluated at least 1 year after RIT, and its relationship with presenting clinical characteristics and pre-RIT parameters was analyzed in 45 patients retrospectively. After RIT, the remission rate was 62.2%, including 13 euthyroidism cases (28.9%) and 15 hypothyroidism cases (33.3%). We found no significant association between the types of thyroid function and age, gender, the 3-h radioactive iodine uptake (RAIU) prior to RIT, or radioactive iodine (131I) dosage. However, a variable 24-h RAIU &gt; 46.31% was found associated with the success rate of RIT. The present study implied that a calculated dose approach for GD is effective, but high failure rates are expected in patients presenting poor 24-h RAIU, particularly those with 24-h RAIU below 46.31%.
Attention, Speech-Language Dissociations, and Stuttering Chronicity
Authors: Singer Cara M. , Walden Tedra A. , Jones Robin M. 
Published: December 2019

SummaryThe purpose of this study was to investigate the singular and joint contributions of speech-language dissociations and attention (i.e., distractibility and attention span) to stuttering chronicity.MethodParticipants, aged 3;0–4;11 (years;months) at an initial visit, were classified as persisting (n= 10; 9 boys), recovered (n= 32; 23 boys), and nonstuttering (n= 28; 19 boys) based on multiple speech and language evaluations spread across 2 years. The evaluations included assessments of articulation, receptive and expressive vocabulary, and omnibus receptive and expressive language. These measures were used to identify speech-language dissociations using a correlation-based statistical approach. Attentional characteristics, which included measures of distractibility and attention span, were based on parent report. Analyses investigated between-group differences related to dissociations and attentional characteristics as well as the relation between these indices.ResultsThere were no significant between-group differences for the persisting and recovered groups on measures of speech-language dissociations; however, the recovered group was found to exhibit less optimal attention span than the persisting group. In addition, children with dissociations exhibited less optimal distractibility and attention spans at the final time point than children without dissociations.ConclusionsPresent results indicate that attention is related to both stuttering chronicity and the presence of speech-language dissociations; however, they do not support the notion that dissociations are associated with stuttering persistence. These results provide novel insights into the complex nature of the association between developmental stuttering, speech-language dissociations, and attention.
Early Speech and Language Development in Children With Nonsyndromic Cleft Lip and/or Palate: A Meta-Analysis
Authors: Lancaster Hope Sparks , Lien Kari M. , Chow Jason C. , Frey Jennifer R. , Scherer Nancy J. , Kaiser Ann P. 
Published: December 2019

ObjectiveThe aim of the study was to conduct a meta-analysis of research examining the early speech and language functioning of young children, birth to age 8;11 (years;months), with nonsyndromic cleft lip and/or palate (NSCL/P) compared to their peers without NSCL/P.MethodWe conducted a random-effects metaregression using 241 effect sizes from 31 studies comparing 955 young children with NSCL/P to 938 typically developing peers on measures of speech and language functioning. Moderators were sample characteristics (i.e., age, cleft type, publication year, and study location) and measurement characteristics (i.e., speech sample material, language modality and domain, and assessment type).ResultsYoung children with NSCL/P scored significantly lower on measures of speech and language compared to children without NSCL/P. Children with NSCL/P had smaller consonant inventories (standardized mean difference effect size [ESg] = −1.24), less accurate articulation (ESg= −1.13), and more speech errors (ESg= 0.93) than their peers. Additionally, children with NSCL/P had poorer expressive (ESg= −0.57) and receptive (ESg= −0.59) language skills than their peers. Age and assessment type moderated effect sizes for expressive language. As children with NSCL/P aged, their expressive language performance became more similar to their peers. Expressive language effect sizes from parent reports and observational language measures (estimated effect size = −0.74) were significantly lower than those from standardized norm-referenced tests (estimated effect size = −0.45).ConclusionsThese findings suggest that young children with NSCL/P experience delays relative to their peers across multiple speech and language constructs. Differences between children with NSCL/P and their typically developing peers appear to decrease with age.Supplemental Materialhttps://doi.org/10.23641/asha.11356904
Hot WHIM counterparts of FUV O VI absorbers: Evidence in the line-of-sight towards quasar 3C 273
Authors: Ahoranta Jussi , Nevalainen Jukka , Wijers Nastasha , Finoguenov Alexis , Bonamente Massimiliano , Tempel Elmo , Tilton Evan , Schaye Joop , Kaastra Jelle , Gozaliasl Ghassem 
Published: December 2019

Aims. We explore the high spectral resolution X-ray data towards the quasar 3C 273 to search for signals of hot (∼106−7 K) X-ray-absorbing gas co-located with two established intergalactic far-ultraviolet (FUV) O VI absorbers.
Methods. We analyze the soft X-ray band grating data of all XMM-Newton and Chandra instruments to search for the hot phase absorption lines at the FUV predicted redshifts. The viability of potential line detections is examined by adopting the constraints of a physically justified absorption model. The WHIM hypothesis is investigated with a complementary 3D galaxy distribution analysis and by detailed comparison of the measurement results to the WHIM properties in the EAGLE cosmological, hydrodynamical simulation.
Results. At one of the examined FUV redshifts, z = 0.09017 ± 0.00003, we measured signals of two hot ion species, O VIII and Ne IX, with a 3.9σ combined significance level. While the absorption signal is only marginally detected in individual co-added spectra, considering the line features in all instruments collectively and assuming collisional equilibrium for absorbing gas, we were able to constrain the temperature (kT = 0.26 ± 0.03 keV) and the column density (NH × Z⊙/Z = 1.3−0.5+0.6 × 1019 cm−2) of the absorber. Thermal analysis indicates that FUV and X-ray absorption relate to different phases, with estimated temperatures, TFUV ≈ 3 × 105, and, TX − ray ≈ 3 × 106 K. These temperatures match the EAGLE predictions for WHIM at the FUV/X-ray measured Nion-ranges. We detected a large scale galactic filament crossing the sight-line at the redshift of the absorption, linking the absorption to this structure.
Conclusions. This study provides observational insights into co-existing warm and hot gas within a WHIM filament and estimates the ratio of the hot and warm phases. Because the hot phase is thermally distinct from the O VI gas, the estimated baryon content of the absorber is increased, conveying the promise of X-ray follow-up studies of FUV detected WHIM in refining the picture of the missing baryons.
Observations of solar chromospheric oscillations at 3 mm with ALMA
Authors: Patsourakos S. , Alissandrakis C. E. , Nindos A. , Bastian T. S. 
Published: December 2019

Aims. We aim to study spatially resolved chromospheric oscillations of the quiet Sun (QS) in the mm-domain at a resolution of a few arcsec, typically 2.4″ × 4.5″.
Methods. We used Atacama Large millimeter and submillimeter Array (ALMA) time series of interferometric observations of the QS obtained at 3 mm with a 2-s cadence and a spatial resolution of a few arcsec. The observations were performed on March 16, 2017 and seven 80″ × 80″ fields of view (FoV) going from disk center to limb were covered, each one observed for 10 min, therefore limiting the frequency resolution of the power spectra to 1.7 mHz. For each FoV, masks for cell and network were derived, and the averaged power spectral densities (PSDs) for the entire FoV, cell, and network were computed. The resulting power spectra were fit with an analytical function in order to derive the frequency and the root-mean-square (rms) power associated with the peaks. The same analysis, over the same FoVs and for the same intervals, was performed for simultaneous Atmospheric Imaging Assembly (AIA) image sequences in 1600 Å.
Results. Spatially resolved chromospheric oscillations at 3 mm, with frequencies of 4.2 ± 1.7 mHz are observed in the QS, in both cell and network. The coherence length-scale of the oscillations is commensurate with the spatial resolution of our ALMA observations. Brightness-temperature fluctuations in individual pixels could reach up to a few hundred K, while the spatially averaged PSDs yield rms in the range ≈55–75 K, i.e., up to ≈1% of the averaged brightness temperatures and exhibit a moderate increase towards the limb. For AIA 1600 Å, the oscillation frequency is 3.7 ± 1.7 mHz. The relative rms is up to 6% of the background intensity, with a weak increase towards the disk center (cell, average). ALMA 3 mm time-series lag AIA 1600 Å by ≈100 s, which corresponds to a formation-height difference of ≈1200 km, representing a novel determination of this important parameter.
Conclusions. The ALMA oscillations that we detected exhibit higher amplitudes than those derived from previous lower (≈10″) resolution observations at 3.5 mm by the Berkeley-Illinois-Maryland Array. Chromospheric oscillations are, therefore, not fully resolved at the length-scale of the chromospheric network, and possibly not even at the spatial resolution of our ALMA observations. Any study of transient brightenings in the mm-domain should take into account the oscillations.
Digitalization of heat energy accounting as a means of improving the reliability of heat supply
Authors: Akhmetova I.G. , Lapin K.V. , Akhmetov T. R. , Balsamova E. Yu. 
Published: December 2019

Annotation
The paper considers the issue of improving the reliability of heat networks due to timely detection of deviations of actual operating conditions from the normative-sections of the heat network located in a humid environment, intensifying the processes of external corrosion of metal. The use of the software complex in real time analyzing and notifying about the operating conditions of thermal networks, deviations from the normative values is proposed. A method for automated calculation of normative values of coolant temperature is developed.
Simple method for asymmetric twin-field quantum key distribution
Authors: Wang Wenyuan , Lo Hoi-Kwong 
Published: December 2019

Abstract
Twin-field quantum key distribution (TF-QKD) can beat the linear bound of repeaterless QKD systems. After the proposal of the original protocol, multiple papers have extended the protocol to prove its security. However, these works are limited to the case where the two channels have equal amount of loss (i.e. are symmetric). In a practical network setting, it is very likely that the channels are asymmetric due to e.g. geographical locations. In this paper we extend the ‘simple TF-QKD’ protocol to the scenario with asymmetric channels. We show that by simply adjusting the two signal states of the two users (and not the decoy states) they can effectively compensate for channel asymmetry and consistently obtain an order of magnitude higher key rate than previous symmetric protocol. It also can provide 2–3 times higher key rate than the strategy of deliberately adding fibre to the shorter channel until channels have equal loss (and is more convenient as users only need to optimize their laser intensities and do not need to physically modify the channels). We also perform simulation for a practical case with three decoy states and finite data size, and show that our method works well and has a clear advantage over prior art methods with realistic parameters.
Spin-dependent radiative deflection in the quantum radiation-reaction regime
Authors: Geng X S , Ji L L , Shen B F , Feng B , Guo Z , Han Q Q , Qin C Y , Wang N W , Wang W Q , Wu Y T , Yan X , Yu Q , Zhang L G , Xu Z Z 
Published: December 2019

Abstract
A new spin-dependent deflection mechanism is revealed by considering the spin-correlated radiation-reaction force during laser-electron collision. We found that such deflection originates from the non-zero work done by the radiation-reaction force along the laser polarization direction in each half-period, which is larger/smaller for spin-anti-paralleled/spin-paralleled electrons. The resulted anti-symmetric deflection is further accumulated when the spin-projection onto the laser magnetic field is reversed in adjacent half-periods. The discovered mechanism dominates over the Stern–Gerlach deflection for electrons of several hundreds of MeV and 10 PW-level laser peak power. The results provide a new perspective to study the strong-field QED physics in quantum radiation-reaction regime and an approach to leverage the study of radiation-dominated and strong-field QED physics via particle spins.