bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development
Authors: Peshkova Iuliia O. , Aghayev Turan , Fatkhullina Aliia R. , Makhov Petr , Titerina Elizaveta K. , Eguchi Satoru , Tan Yin Fei , Kossenkov Andrew V. , Khoreva Marina V. , Gankovskaya Lyudmila V. , Sykes Stephen M. , Koltsova Ekaterina K. 
Published: November 2019

AbstractAbdominal aortic aneurysm (AAA) is a prevalent life-threatening disease, where aortic wall degradation is mediated by accumulated immune cells. Although cytokines regulate inflammation within the aorta, their contribution to AAA via distant alterations, particularly in the control of hematopoietic stem cell (HSC) differentiation, remains poorly defined. Here we report a pathogenic role for the interleukin-27 receptor (IL-27R) in AAA, as genetic ablation of IL-27R protects mice from the disease development. Mitigation of AAA is associated with a blunted accumulation of myeloid cells in the aorta due to the attenuation of Angiotensin II (Ang II)-induced HSC expansion. IL-27R signaling is required to induce transcriptional programming to overcome HSC quiescence and increase differentiation and output of mature myeloid cells in response to stress stimuli to promote their accumulation in the diseased aorta. Overall, our studies illuminate how a prominent vascular disease can be distantly driven by a cytokine-dependent regulation of bone marrow precursors.
Template-controlled on-surface synthesis of a lanthanide supernaphthalocyanine and its open-chain polycyanine counterpart
Authors: Fan Qitang , Luy Jan-Niclas , Liebold Martin , Greulich Katharina , Zugermeier Malte , Sundermeyer Jörg , Tonner Ralf , Gottfried J. Michael 
Published: November 2019

AbstractPhthalocyanines possess unique optical and electronic properties and thus are widely used in (opto)electronic devices, coatings, photodynamic therapy, etc. Extension of their π-electron systems could produce molecular materials with red-shifted absorption for a broader range of applications. However, access to expanded phthalocyanine analogues with more than four isoindoline units is challenging due to the limited synthetic possibilities. Here, we report the controlled on-surface synthesis of a gadolinium-supernaphthalocyanine macrocycle and its open-chain counterpart poly(benzodiiminoisoindoline) on a silver surface from a naphthalene dicarbonitrile precursor. Their formation is controlled by the on-surface high-dilution principle and steered by different metal templates, i.e., gadolinium atoms and the bare silver surface, which also act as oligomerization catalysts. By using scanning tunneling microscopy, photoemission spectroscopy, and density functional theory calculations, the chemical structures along with the mechanical and electronic properties of these phthalocyanine analogues with extended π-conjugation are investigated in detail.
Measuring the shape of the biodiversity-disease relationship across systems reveals new findings and key gaps
Authors: Halliday Fletcher W. , Rohr Jason R. 
Published: November 2019

AbstractDiverse host communities commonly inhibit the spread of parasites at small scales. However, the generality of this effect remains controversial. Here, we present the analysis of 205 biodiversity–disease relationships on 67 parasite species to test whether biodiversity–disease relationships are generally nonlinear, moderated by spatial scale, and sensitive to underrepresentation in the literature. Our analysis of the published literature reveals that biodiversity–disease relationships are generally hump-shaped (i.e., nonlinear) and biodiversity generally inhibits disease at local scales, but this effect weakens as spatial scale increases. Spatial scale is, however, related to study design and parasite type, highlighting the need for additional multiscale research. Few studies are unrepresentative of communities at low diversity, but missing data at low diversity from field studies could result in underreporting of amplification effects. Experiments appear to underrepresent high-diversity communities, which could result in underreporting of dilution effects. Despite context dependence, biodiversity loss at local scales appears to increase disease, suggesting that at local scales, biodiversity loss could negatively impact human and wildlife populations.
Optical molecular imaging can differentiate metastatic from benign lymph nodes in head and neck cancer
Authors: Nishio Naoki , van den Berg Nynke S. , van Keulen Stan , Martin Brock A. , Fakurnejad Shayan , Teraphongphom Nutte , Chirita Stefania U. , Oberhelman Nicholas J. , Lu Guolan , Horton Crista E. , Kaplan Michael J. , Divi Vasu , Colevas A. Dimitrios , Rosenthal Eben L. 
Published: November 2019

AbstractIdentification of lymph node (LN) metastasis is essential for staging of solid tumors, and as a result, surgeons focus on harvesting significant numbers of LNs during ablative procedures for pathological evaluation. Isolating those LNs most likely to harbor metastatic disease can allow for a more rigorous evaluation of fewer LNs. Here we evaluate the impact of a systemically injected, near-infrared fluorescently-labeled, tumor-targeting contrast agent, panitumumab-IRDye800CW, to facilitate the identification of metastatic LNs in the ex vivo setting for head and neck cancer patients. Molecular imaging demonstrates a significantly higher mean fluorescence signal in metastatic LNs compared to benign LNs in head and neck cancer patients undergoing an elective neck dissection. Molecular imaging to preselect at-risk LNs may thus allow a more rigorous examination of LNs and subsequently lead to improved prognostication than regular neck dissection.
Voltage-gated optics and plasmonics enabled by solid-state proton pumping
Authors: Huang Mantao , Jun Tan Aik , Büttner Felix , Liu Hailong , Ruan Qifeng , Hu Wen , Mazzoli Claudio , Wilkins Stuart , Duan Chuanhua , Yang Joel K. W. , Beach Geoffrey S. D. 
Published: November 2019

AbstractDevices with locally-addressable and dynamically tunable optical properties underpin emerging technologies such as high-resolution reflective displays and dynamic holography. The optical properties of metals such as Y and Mg can be reversibly switched by hydrogen loading, and hydrogen-switched mirrors and plasmonic devices have been realized, but challenges remain to achieve electrical, localized and reversible control. Here we report a nanoscale solid-state proton switch that allows for electrical control of optical properties through electrochemical hydrogen gating. We demonstrate the generality and versatility of this approach by realizing tunability of a range of device characteristics including transmittance, interference color, and plasmonic resonance. We further discover and exploit a giant modulation of the effective refractive index of the gate dielectric. The simple gate structure permits device thickness down to ~20 nanometers, which can enable device scaling into the deep subwavelength regime, and has potential applications in addressable plasmonic devices and reconfigurable metamaterials.
Rapid microevolution of biofilm cells in response to antibiotics
Authors: Penesyan Anahit , Nagy Stephanie S. , Kjelleberg Staffan , Gillings Michael R. , Paulsen Ian T. 
Published: November 2019

AbstractInfections caused by Acinetobacter baumannii are increasingly antibiotic resistant, generating a significant public health problem. Like many bacteria, A. baumannii adopts a biofilm lifestyle that enhances its antibiotic resistance and environmental resilience. Biofilms represent the predominant mode of microbial life, but research into antibiotic resistance has mainly focused on planktonic cells. We investigated the dynamics of A. baumannii biofilms in the presence of antibiotics. A 3-day exposure of A. baumannii biofilms to sub-inhibitory concentrations of antibiotics had a profound effect, increasing biofilm formation and antibiotic resistance in the majority of biofilm dispersal isolates. Cells dispersing from biofilms were genome sequenced to identify mutations accumulating in their genomes, and network analysis linked these mutations to their phenotypes. Transcriptomics of biofilms confirmed the network analysis results, revealing novel gene functions of relevance to both resistance and biofilm formation. This approach is a rapid and objective tool for investigating resistance dynamics of biofilms.
Two-axis quantum control of a fast valley qubit in silicon
Authors: Penthorn Nicholas E. , Schoenfield Joshua S. , Rooney John D. , Edge Lisa F. , Jiang HongWen 
Published: November 2019

AbstractQuantum dots in silicon are a promising architecture for semiconductor quantum computing due to a high degree of electric control and compatibility with existing silicon fabrication processes. Although electron charge and spin are prominent methods for encoding the qubit state, valley states in silicon can also store quantum information via valley-orbit coupling with protection against charge noise. By observing coherent oscillations between valley states in a Si/SiGe double quantum dot device tuned to the two-electron charge configuration, we measure the valley energy splitting in both quantum dots individually. We further demonstrate two-axis quantum control of the valley qubit using gated pulse sequences with X and Z rotations occurring within a fast operation time of 300 ps. This control is used to completely map out the surface of the Bloch sphere in a single phase-space plot that is subsequently used for state and process tomography.
Prophylactic effects of isomaltodextrin in a Balb/c mouse model of egg allergy
Authors: Mine Yoshinori , Jin Yan , Zhang Hua , Rupa Prithy , Majumder Kaustav , Sakurai Takeo , Taniguchi Yoshifumi , Takagaki Ryodai , Watanabe Hikaru , Mitsuzumi Hitoshi 
Published: November 2019

AbstractThe aim of this study was to evaluate the potential effects of isomaltodextrin (IMD), a dietary saccharide polymer derived from enzymatically produced from starch, on the ability to alter immune response (IR) bias to hen egg ovalbumin (Ova) induced allergic inflammation in mice. Groups of Balb/c mice were pre-treated with various doses of IMD in drinking water (1.0, 2.5, and 5.0% w/v) for 6 weeks and subsequently sensitized to the Ova together with continuous administration of IMD. To evaluate changes in immune response bias, immunoglobulin isotype-associated antibody activity, concentrations of type 1 and 2 cytokines and the percentage of T-regulatory cells (T-regs) in blood were measured. Clinical signs of allergy were assessed after oral challenge with Ova. Treatment with IMD did not significantly alter the frequency of clinical signs, however there was a trend in the overall reduction of clinical signs. Effect on IR bias was observed in the treatment groups as reflected by reduction in a type 1-biased phenotype as evident by decrease in isotype-specific IgE, IgG and increase in IL-12 cytokine production and a high proportion of T-regs. This study revealed that IMD could be a useful prophylactic candidate for alteration of allergic IR bias in mice and an immune-stimulator for reducing egg induced allergic reactions.
A transcriptomic study of Williams-Beuren syndrome associated genes in mouse embryonic stem cells
Authors: De Cegli Rossella , Iacobacci Simona , Fedele Anthony , Ballabio Andrea , di Bernardo Diego 
Published: November 2019

AbstractWilliams-Beuren syndrome (WBS) is a relatively rare disease caused by the deletion of 1.5 to 1.8 Mb on chromosome 7 which contains approximately 28 genes. This multisystem disorder is mainly characterized by supravalvular aortic stenosis, mental retardation, and distinctive facial features. We generated mouse embryonic stem (ES) cells clones expressing each of the 4 human WBS genes (WBSCR1, GTF2I, GTF2IRD1 and GTF2IRD2) found in the specific delated region 7q11.23 causative of the WBS. We generated at least three stable clones for each gene with stable integration in the ROSA26 locus of a tetracycline-inducible upstream of the coding sequence of the genet tagged with a 3xFLAG epitope. Three clones for each gene were transcriptionally profiled in inducing versus non-inducing conditions for a total of 24 profiles. This small collection of human WBS-ES cell clones represents a resource to facilitate the study of the function of these genes during differentiation.
Global soil, landuse, evapotranspiration, historical and future weather databases for SWAT Applications
Authors: Abbaspour K. C. , Vaghefi S. Ashraf , Yang H. , Srinivasan R. 
Published: November 2019

AbstractLarge-scale distributed watershed models are data-intensive, and preparing them consumes most of the research resources. We prepared high-resolution global databases of soil, landuse, actual evapotranspiration (AET), and historical and future weather databases that could serve as standard inputs in Soil and Water Assessment Tool (SWAT) models. The data include two global soil maps and their associated databases calculated with a large number of pedotransfer functions, two landuse maps and their correspondence with SWAT’s database, historical and future daily temperature and precipitation data from five IPCC models with four scenarios; and finally, global monthly AET data. Weather data are 0.5° global grids text-formatted for direct use in SWAT models. The AET data is formatted for use in SWAT-CUP (SWAT Calibration Uncertainty Procedures) for calibration of SWAT models. The use of these global databases for SWAT models can speed up the model building by 75–80% and are extremely valuable in areas with limited or no physical data. Furthermore, they can facilitate the comparison of model results in different parts of the world.
Vertical distribution of aerosols in dust storms during the Arctic winter
Authors: Dagsson-Waldhauserova Pavla , Renard Jean-Baptiste , Olafsson Haraldur , Vignelles Damien , Berthet Gwenaël , Verdier Nicolas , Duverger Vincent 
Published: November 2019

AbstractHigh Latitude Dust (HLD) contributes 5% to the global dust budget, but HLD measurements are sparse. Dust observations from Iceland provide dust aerosol distributions during the Arctic winter for the first time, profiling dust storms as well as clean air conditions. Five winter dust storms were captured during harsh conditions. Mean number concentrations during the non-dust flights were <5 particles cm−3 for the particles 0.2–100 µm in diameter and >40 particles cm−3 during dust storms. A moderate dust storm with >250 particles cm−3 (2 km altitude) was captured on 10th January 2016 as a result of sediments suspended from glacial outburst flood Skaftahlaup in 2015. Similar concentrations were reported previously in the Saharan air layer. Detected particle sizes were up to 20 µm close to the surface, up to 10 µm at 900 m altitude, up to 5 µm at 5 km altitude, and submicron at altitudes >6 km. Dust sources in the Arctic are active during the winter and produce large amounts of particulate matter dispersed over long distances and high altitudes. HLD contributes to Arctic air pollution and has the potential to influence ice nucleation in mixed-phase clouds and Arctic amplification.
Tilting dependence and anisotropy of anomaly-related magnetoconductance in type-II Weyl semimetals
Authors: Ishizuka Hiroaki , Nagaosa Naoto 
Published: November 2019

AbstractWe theoretically study chiral magnetic effect in type-II Weyl semimetals based on a concise formalism for the magnetoconductance in the semiclassical limit. Using the formula, we find that the anomaly-related current is generally dominated by the contribution from the Weyl nodes when the Fermi level is sufficiently close to the nodes. This is related to the fact that the current is proportional to the square of the Berry curvature, which enhances the contribution from the electrons around the Weyl nodes. The increase and the anisotropy of magnetoconductance induced by the tilting is also explained in a comprehensive way.
Differential effects of D-cycloserine and amantadine on motor behavior and D2/3 receptor binding in the nigrostriatal and mesolimbic system of the adult rat
Authors: Nikolaus Susanne , Wittsack Hans-Jörg , Wickrath Frithjof , Müller-Lutz Anja , Hautzel Hubertus , Beu Markus , Antke Christina , Mamlins Eduards , De Souza Silva Maria Angelica , Huston Joseph P. , Antoch Gerald , Müller Hans-Wilhelm 
Published: November 2019

AbstractD-cycloserine (DCS) and amantadine (AMA) act as partial NMDA receptor (R) agonist and antagonist, respectively. In the present study, we compared the effects of DCS and AMA on dopamine D2/3R binding in the brain of adult rats in relation to motor behavior. D2/3R binding was determined with small animal SPECT in baseline and after challenge with DCS (20 mg/kg) or AMA (40 mg/kg) with [123I]IBZM as radioligand. Immediately post-challenge, motor/exploratory behavior was assessed for 30 min in an open field. The regional binding potentials (ratios of the specifically bound compartments to the cerebellar reference region) were computed in baseline and post-challenge. DCS increased D2/3R binding in nucleus accumbens, substantia nigra/ventral tegmental area, thalamus, frontal, motor and parietal cortex as well as anterodorsal and posterior hippocampus, whereas AMA decreased D2/3R binding in nucleus accumbens, caudateputamen and thalamus. After DCS, ambulation and head-shoulder motility were decreased, while sitting was increased compared to vehicle and AMA. Moreover, DCS increased rearing relative to AMA. The regional elevations of D2/3R binding after DCS reflect a reduction of available dopamine throughout the mesolimbocortical system. In contrast, the reductions of D2/3R binding after AMA indicate increased dopamine in nucleus accumbens, caudateputamen and thalamus. Findings imply that, after DCS, nigrostriatal and mesolimbic dopamine levels are directly related to motor/exploratory activity, whereas an inverse relationship may be inferred for AMA.
Stochastic optimization on complex variables and pure-state quantum tomography
Authors: Utreras-Alarcón A. , Rivera-Tapia M. , Niklitschek S. , Delgado A. 
Published: November 2019

AbstractReal-valued functions of complex arguments violate the Cauchy-Riemann conditions and, consequently, do not have Taylor series expansion. Therefore, optimization methods based on derivatives cannot be directly applied to this class of functions. This is circumvented by mapping the problem to the field of the real numbers by considering real and imaginary parts of the complex arguments as the new independent variables. We introduce a stochastic optimization method that works within the field of the complex numbers. This has two advantages: Equations on complex arguments are simpler and easy to analyze and the use of the complex structure leads to performance improvements. The method produces a sequence of estimates that converges asymptotically in mean to the optimizer. Each estimate is generated by evaluating the target function at two different randomly chosen points. Thereby, the method allows the optimization of functions with unknown parameters. Furthermore, the method exhibits a large performance enhancement. This is demonstrated by comparing its performance with other algorithms in the case of quantum tomography of pure states. The method provides solutions which can be two orders of magnitude closer to the true minima or achieve similar results as other methods but with three orders of magnitude less resources.
Genetic deletion of S6k1 does not rescue the phenotypic deficits observed in the R6/2 mouse model of Huntington’s disease
Authors: Irvine Elaine E. , Katsouri Loukia , Plattner Florian , Al-Qassab Hind , Al-Nackkash Rand , Bates Gillian P. , Withers Dominic J. 
Published: November 2019

AbstractHuntington’s disease (HD) is a fatal inherited autosomal dominant neurodegenerative disorder caused by an expansion in the number of CAG trinucleotide repeats in the huntingtin gene. The disease is characterized by motor, behavioural and cognitive symptoms for which at present there are no disease altering treatments. It has been shown that manipulating the mTOR (mammalian target of rapamycin) pathway using rapamycin or its analogue CCI-779 can improve the cellular and behavioural phenotypes of HD models. Ribosomal protein S6 kinase 1 (S6K1) is a major downstream signalling molecule of mTOR, and its activity is reduced by rapamycin suggesting that deregulation of S6K1 activity may be beneficial in HD. Furthermore, S6k1 knockout mice have increased lifespan and improvement in age-related phenotypes. To evalute the potential benefit of S6k1 loss on HD-related phenotypes, we crossed the R6/2 HD model with the long-lived S6k1 knockout mouse line. We found that S6k1 knockout does not ameliorate behavioural or physiological phenotypes in the R6/2 mouse model. Additionally, no improvements were seen in brain mass reduction or mutant huntingtin protein aggregate levels. Therefore, these results suggest that while a reduction in S6K1 signalling has beneficial effects on ageing it is unlikely to be a therapeutic strategy for HD patients.
Preventative and Therapeutic Effects of Low-dose Ionizing Radiation on the Allergic Response of Rat Basophilic Leukemia Cells
Authors: Joo Hae Mi , Hong Eun Hee , Cho Seong-Jun , Nam Seon Young , Kim Ji Young 
Published: November 2019

AbstractThe prevalence of allergies has increased over the last four decades. In allergic reactions, mast cells induce a hypersensitive immune response to a substance that is normally harmless. Ionizing radiation has different biological effects depending on the dose and dose rate. In this study, we investigated whether low-dose irradiation before (preventative effect) or after (therapeutic effect) an antigen-antibody reaction has an anti-allergic effect. To test this, we activated rat basophilic leukemia (RBL-2H3) mast cells with anti-2,4-dinitrophenyl IgE (antibody) and 2,4-dinitrophenyl human serum albumin, which served as an antigen. To test for both the potential of a preventative effect and a therapeutic effect, we irradiated mast cells both before and after mast cell activation, and we measured mediator release and signaling pathway activity. Low-dose ionizing radiation suppressed mediator release from RBL-2H3 mast cells activated by the antigen-antibody reaction regardless of when the mast cells were irradiated. These results were due to the suppression of FcεRI expression. Therefore, we suggest that low-dose ionizing radiation has a preventative and therapeutic effect in allergic reactions via the FcεRI-mediated RBL-2H3 mast cell activation system.
Quantitative basis of meiotic chromosome synapsis analyzed by electron tomography
Authors: Spindler Marie-Christin , Filbeck Sebastian , Stigloher Christian , Benavente Ricardo 
Published: November 2019

AbstractThe synaptonemal complex is a multiprotein complex, which mediates the synapsis and recombination between homologous chromosomes during meiosis. The complex is comprised of two lateral elements and a central element connected by perpendicular transverse filaments (TFs). A 3D model based on actual morphological data of the SC is missing. Here, we applied electron tomography (ET) and manual feature extraction to generate a quantitative 3D model of the murine SC. We quantified the length (90 nm) and width (2 nm) of the TFs. Interestingly, the 80 TFs/µm are distributed asymmetrically in the central region of the SC challenging available models of SC organization. Furthermore, our detailed 3D topological analysis does not support a bilayered organization of the central region as proposed earlier. Overall, our quantitative analysis is relevant to understand the functions and dynamics of the SC and provides the basis for analyzing multiprotein complexes in their morphological context using ET.