bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mesenchymal Stem Cells Induce Regulatory T-cell Population in Human SLE
Authors: Ikhsan Riyadh , Putra Agung , Munir Delfitri , Darlan Dewi Masyithah , Suntoko Bantar , Kustiyah Azizah Retno , Alif Iffan , Prasetio Ardi 
Published: April 2020

Background: The mechanisms underlying peripheral disorders during systemic lupus erythematosus (SLE) were found to be shared with tolerance disorders and mediated by T-regulator (T-reg) cells. Mesenchymal stem cells (MSCs) may inhibit T-cell subset differentiation and induce the T-reg cell phenotype. However, the capacity of MSCs to promote functional T-reg cells in SLE patients remains unclear.
Objectives: This study aimed to analyze the capacity of MSCs to induce the production of functional CD4+ CD25+ Foxp3+ T-reg cells, in vitro, under co-culture conditions with human SLE cells.
Methods: This study used a pre- and post-test control group design. Peripheral blood mononuclear cells (PBMCs) were extracted from SLE patients at the Kariadi Hospital, and MSCs were derived from human umbilical cords (hUCs) The PBMC control group was treated with standard medium, and the treatment group was co-cultured with hUC-MSCs. After 24 hours of co-culture incubation, T-reg cells were removed from the PBMC pool, using magnetic-activated cell sorting (MACS), and the population was assessed using the trypan blue exclusion assay.
Results: A significant increase in the population of T-reg cells was observed (P < 0.001) after 24 hours of co-culture incubation with hUC-MSCs.
Conclusion: This study concluded that MSCs have the capacity to enhance the T-reg population in human SLE PBMCs.
Bangladesh Journal of Medical Science Vol.19(4) 2020 p.743-748
UVB Dose Optimization for Phototherapy in Vitamin D Deficiency : Profile Analysis of Vitamin D, TNF-α, Vascular Endothelial Growth Factor (VEGF) and Platelet Derived Growth Factor (PDGF) in Wistar Rats
Authors: Arsita Cynthia , Nasihun Taufiqurrachman , Hussaana Atina 
Published: April 2020

Background : UVB radiation responsible for the most important biological effects including Vitamin D3 synthesis and inflammation. UVB radiation are absorbed by 7-dehydrocholesterol in the plasma membrane of epidermal cells resulting in production of cis-previtamin D3. In the other hand, an exposure to UVB leads to cutaneous tissue inflammation modulates by TNF-α which also increases platelet activating factor. VEGF and PDGF induced by TNF-α during wound healing, characterized with angiogenesis and reephitalization. Furthermore, vitamin D plays a role in inflammation inhibition and upregulates growth factors. However, the study of the mechanism has not yet been thoroughly investigated.
Methods: This study uses post test only group design, subjected wistar rats divided into four groups. Control group, non irradiated with UVB, and the other three groups, treated with graded UVB dose started with 1 MED (50 mJ/cm2), 2 MED (100mJ/cm2) and 3 MED (150 mJ/cm2) and investigated at 6, 12, 24 and 48 hours post UVB irradiation.
Result : The serum level of vitamin D, VEGF and PDGF were increasing due to UVB dose addition. The highest level was reached at 6 hours post radiation using 3 MED, which gradually decrease up to 48 hours (p =0,000). The rise of vitamin D after UVB radiation, inhibit TNF-α induction in every dose accordant UVB dose addition and the lowest level is using 3 MED at 12 hours post radiation (p =0,000). TNF-α reach its highest level at 24 hours post radiation using 1 MED, it is related with the acute phase of inflammation.
Conclusion : This study reveal that higher UVB irradiance increases vitamin D and inhibit TNF-α which also promotes VEGF and PDGF.
Bangladesh Journal of Medical Science Vol.19(4) 2020 p.749-754
Ultrasound guided psoas compartment block and sciatic nerve block for revision arthroplasty of the knee performed two times in a patient with ankylosing spondylitis
Authors: Koçoğlu Hasan , İnal Ferda Yılmaz , Koruk Senem , Özkan Korhan , Özden Mesure Gül Nihan , Akpınar Fuat 
Published: April 2020

Anesthetic management including endotracheal intubation and neuroaxial blocks is challenging in patients with ankylosing spondylitis because of the stifness of vertebral joints. Peripheral blocks in these patients may be helpful although it is not common. A 56 year-old male patient with ankylosing spondylitis having the history of total knee arthroplasty and difficult airway management was operated for the contracted knee joint prosthesis. Anteromedialisation of tuberositas tibia was performed with combination of ultrasound guided psoas compartment block (PCB) and sciatic nevre block (SNB), and repeated forty days later because of the displacement of the osteotomy site. We conclude that PCB together with SNB may be performed for knee surgery in patients with severe ankylosing spondylitis.
Bangladesh Journal of Medical Science Vol.19(4) 2020 p.772-774
The art of medicine: a developing country version
Authors: Irshadullah Naseeb Muhammad 
Published: April 2020

‘The art of medicine’ is a commonly discussed topic in clinical medicine. It is that aspect of medical practice which makes the physicians more humane over medical scientists. Though frequently reminded by the teachers in academic environment, in a developing country like Bangladesh, the art of medicine is barely practised at any level of care. An effort is made in this article to depict the practice of medicine in developing countries mostly devoid of art, the reasons behind, and some suggestions.
Bangladesh Journal of Medical Science Vol.19(4) 2020 p.778-779
DERAJAT STRES IBU HAMIL DAN PREEKLAMSIA MEMPENGARUHI KEJADIAN PERSALINAN PREMATUR
Authors: Saleha Nurmukaromatis , Delfina Rina , Maiyulis Maiyulis 
Published: April 2020

ABSTRAK Prematuritas menjadi penyebab sekitar 60%-80% kematian neonatus secara global. Penelitian ini bertujuan untuk melihat hubungan faktor stres pada ibu hamil dan preeklamsia dengan kejadian persalinan prematur. Penelitian ini adalah penelitian kuantitatif dengan desain studi kasus kontrol. Sampel sebanyak 152 orang diamana 62 orang ibu bersalin prematur dan 90 orng ibu bersalin aterm. Data dikumpulkan dengan consecutive sampling dan dianalisis menggunakan uji Chi Square. Hasil penelitian didapatkan hubungan derajat stres dengan kejadian prematur yaitu p=0,036; 95% CI=0,682-6,308 sedangkan preeklamsia mempunyai nilai p value 0,001 dan 95% CI 1,874-25,849 dengan nilai RR 6,960. Dapat disimpulkan derajat stres dan preeklamsia menjadi faktor penyebab terjadinya preeklamsia di Bengkulu tahun 2015. Peneliti menyarankan bahwasanya perawat maternitas harus meningkatkan intervensi dalam menanggulangi stres dan preeklamsia pada ibu saat hamil termasuk faktor-faktor lain yang mempengaruhi kejadian prematur.Kata Kunci:Derajat stres, preeklamsia, persalinan prematur
HUBUNGAN PERILAKU PROSOSIAL DENGAN PRESTASI AKADEMIK MAHASISWA PRODI D3 KEPERAWATAN FMIPA UNIVERSITAS BENGKULU
Authors: Aprilatutini Titin , Yustisia Nova , Maiyulis Maiyulis 
Published: April 2020

Prestasi akademik merupakan suatu pencapaian tingkat keberhasilan tentang suatu tujuan, karena suatu usaha belajar telah dilakukan oleh seseorang secara optimal. Adanya perubahan status siswa menjadi mahasiswa dengan situasi dan lingkungan yang berbeda menyebabkan beberapa mahasiswa kadang mengalami masalah belajar sehingga menyebabkan turunnya prestasi akademik di tahun pertama proses pembelajaran. Tujuan penelitian untuk mengetahui hubungan perilaku prososial dengan prestasi akademik mahasiswa Prodi D3 Keperawatan FMIPA Universitas Bengkulu. Penelitian dengan pendekatan kuantitatif jenis korelasional. Sampel 51 responden dengan total sampling. Pengumpulan data melalui kuesioner. Hipotesis dengan uji-statistik chi- square. Hasil penelitian menunjukkan ada hubungan perilaku prososial dengan prestasi akademik nilap p value = 0,032 maka p < ? (0,01<0,05). Kesimpulan: terdapat hubungan antara perilaku prososial dengan prestasi akademik Mahasiswa Prodi D3 Keperawatan FMIPA Universitas Bengkulu. Hasil penelitian diharapkan dapat menjadi bahan pertimbangan dalam menentukan review dan revisi kurikulum D3 Keperawatan dengan menambah muatan soft skill disetiap mata ajar agar menghasilkan lulusan yang siap pakai, memiliki prestasi akademik yang baik dan perilaku prososial yang mendukung.
Manajemen Backup Data untuk Penyelamatan Data Nasabah pada Sistem Informasi Perbankan (Studi Kasus : PT Bank XYZ)
Authors: Rosano Andi , Sudaradjat Djadjat 
Published: April 2020

Data sistem informasi online pada PT Bank XYZ merupakan database yang tersimpan pada web/email server bank yang dapat diakses secara online oleh pemakai. Beberapa faktor internal telah menjadi penyebab kerusakan server dan berakibat tidak beroperasinya sistem. Salah satu cara untuk menyelamatkan data dari kehilangan atau kerusakan adalah melalui manajemen backup data yang pelaksanaanya dijalankan secara teratur. Solusi untuk masalah ini adalah penggabungan metode full backup dan incremental backup dalam manajemen backup data, dimana metode ini sangat mudah digunakan serta ekonomis. Langkah berikutnya setelah backup data adalah proses restore yang merupakan proses pengembalian atau recovery data yang sangat penting apabila terjadi kerusakan data. Pada tulisan ini akan dibahas metode backup data dalam upaya penyelamatan data online. Dalam pemilihan metode backup ini sangat tergantung pada keandalan sistem dan kinerja, sehingga proses penyelamatan data dilakukan dengan tepat dan aman

Kata Kunci; backup, database, incremental, online, recovery, restore, server
Perancangan Sistem Informasi Pembuatan E-Invoice Pada PT. Hasta Perkasa Graha Berbasis Web
Authors: Yulianto Agus , Ariani Ani 
Published: April 2020

Abstract—Invoice merupakan surat tagihan resmi dari perusahaan yang ditujukan untuk pelanggan yang berisi barang ataupun jasa, qty dan jumlah harga sesuai dengan purchase order. Kecepatan dalam pembuatan invoice pun diperlukan agar surat tagihan dapat segera diterima oleh pelanggan, namun masih banyak perusahaan yang membuat invoice secara manual. Karena pembuatan invoice masih secara manual maka invoice pun rentan terhadap kesalahan dalam pengetikan dan hilang nya data transaksi pelanggan. Dalam hal ini, tentu diperlukan adanya sebuah solusi agar pembuatan invoice ini menjadi lebih mudah, efisien untuk menghindari kesalahan-kesalahan yang tadi penulis sebutkan. Penulis membuat sistem informasi berbasis web yang dapat digunakan sebagai pembuatan invoice yang telah terkomputerisasi.
Evaluation of physical-chemical and microbiological characteristics of freeze-dried and reydrated yogurt
Authors: Yamaguchi Shana Kimi Farias , Souza Carolina Krebs de , Bertoli Sávio Leandro , Carvalho Lisiane Fernandes de 
Published: April 2020

This study aimed to evaluate the physical-chemical characteristics and the viability of lactic acid bacteria during the fermentation process of the yogurt and after the freeze-dried process, in addition to testing three thickener formulations for the rehydration of the yogurt powder. During the fermentation process, the production of lactic acid and the growth of lactic acid bacteria were accompanied. Before and after freeze-dried process, yogurt was analyzed for pH, titratable acidity, carbohydrates, proteins, lipids and viable lactic acid bacteria. After lyophilization, three thickener formulations were tested to evaluate the rehydration of powdered yogurt. At the end of the fermentation process, it was verified that the lactic acid bacteria grew to reach 7.8.107 UFC.g-1 and the acidity obtained was 9.27 g.L-1. The viable lactic acid bacteria count of freeze-dried and non-freeze-dried yogurt was 5.6.107 CFU.g-1 and 7.8.107 CFU.g-1, respectively. Non-freeze-dried and freeze-dried yogurts showed a content of 20.8% and 21.0% carbohydrates, 4.0% and 3.6% protein and 3.7% and 2.7% lipids, respectively. The combination of thickeners that provided viscosity similar to commercial yogurts was the guar gum, pectin and maltodextrin mix. Thus, it was possible to verify that the freeze-drying process maintains the physical-chemical characteristics and viability of lactic acid bacteria. In addition, the developed yogurt presented easy reconstitution at the time of consumption.
Visibilidade da equipe de transplante de medula óssea no contexto ecossistêmico
Authors: Nunes Simone Dos Santos , Siqueira Hedi Crecencia Heckler de , Montesinos Maria José López , Zamberlan Cláudia , Rodrigues Sidiane Teixeira , De Paula Saul Ferraz 
Published: April 2020

Objetivo: Analisar, no contexto ecossistêmico, a visibilidade profissional dos membros da equipe de Transplante de Medula Óssea, na visão do usuário. Métodos: Abordagem quali-quantitativa, utilizando a Análise de Conteúdo de Bardin e análise estatística descritiva dos resultados, empregando o Statistical Package for the Social Sciences. Realizou-se a análise da frequência, porcentagem das variáveis observadas e análise estatística de estimação intervalar. Na coleta de dados utilizou-se de um instrumento com 35 questões. A amostra constitui-se de 40 entrevistados em dois serviços de transplante de dois países. Resultados: Os dados demonstram que os usuários visualizaram mais de um profissional a oferecer orientações para o cuidado no domicílio. 90% (n=36) responderam que foi o(a) médico(a) que mais orientou para a alta; 72,5% (n=29) referiram o enfermeiro(a), 42,5% (n=17) o nutricionista e 27,5% (n=11) citaram o atendimento de outros profissionais. Conclusão: A visibilidade profissional dos membros da equipe de transplante, na visão do usuário, demonstrou ainda estar influenciada pelo modelo biomédico de saúde, evoluindo, gradativamente, para a identificação de representatividades profissionais, perpassando pela conquista dos espaços destinados a cada membro na equipe de saúde do transplante em relação a orientações para a alta hospitalar após transplante.
Vivências de adolescentes relacionadas à internação por condições sensíveis a atenção primaria à saúde
Authors: Senhem Graciela Dutra , Gonçalves Cibele Aires , Barros Amanda Peres Zubiaurre de , Ribeiro Aline Cammarano , Cogo Silvana Bastos , Badke Marcio Rossato , Ianzer Fabiano Ritta Malagues , Polletti Gabriela Coden , Machado Anahy da Silva , Rosa Mariane Daronch da 
Published: April 2020

O estudo objetivou conhecer as vivências de adolescentes relacionadas à internação por condições sensíveis a Atenção Primária à Saúde. Trata-se de um estudo com abordagem qualitativa, realizado em um hospital público de referência no município de Santa Maria. A coleta aconteceu por meio de entrevista semiestruturada que foi realizada no segundo semestre de 2019. Os dados qualitativos foram submetidos a Análise Temática de Conteúdo. Destaca-se que toda a pesquisa foi regida pela Resolução 466/2012, respeitando os aspectos éticos de pesquisas realizadas com seres humanos. Para os adolescentes vivenciar a hospitalização fez emergir reações emocionais negativas associadas à ruptura e à separação da família e dos pares. Tais vivências, também, estiveram relacionadas à condição de saúde e aos procedimentos técnicos a que foram submetidos durante o tratamento. Para alguns participantes, a hospitalização esteve permeada por sentimentos ambíguos, pois ora entendiam a importância do tratamento para a melhoria de sua condição de saúde, ora não aceitavam ter sua rotina interrompida. Espera-se que a pesquisa possibilite aprimorar a atenção à saúde do adolescente por meio da identificação das causas de internação por condições sensíveis a atenção primária, reduzindo tais índices.
Cardiopatias congênitas em um hospital pediátrico
Authors: Franceschi Jarbas , Marques Frederico Manoel , Souza Patrícia Alves de 
Published: April 2020

Introdução: cardiopatias congênitas são malformações importantes que comprometem tanto a sobrevivência como a qualidade de vida do paciente. Essas podem ser detectadas nos primeiros dias de vida ou vida intrauterina. Segundo a Sociedade Brasileira de Cardiologia, as doenças cardiovasculares aparecem em primeiro lugar entre as causas de morte no Brasil. Objetivo: identificar as cardiopatias congênitas. Metodologia: a partir da leitura dos prontuários dos pacientes de um hospital pediátrico de médio porte (anos de 2016 e 2018), foram pesquisados os Ecocardiogramas (ECO) e Eletrocardiogramas (ECG) que identificaram as cardiopatias congênitas. Resultados: foram selecionados 163 prontuários os quais os pacientes realizaram ECO e ECG, sendo 70 referentes ao ano de 2016 e 93 referentes ao ano de 2018. A prevalência em ambos os anos: faixa etária de menores de 01 ano de idade e sexo masculino (61,43% em 2016 e 58,07% em 2018). Do total, 30,06% apresentam em seu prontuário algum tipo de cardiopatia (34,28% em 2016 e 26,88% em 2018), a mais prevalente é do tipo Comunicação Interventricular (06 em 2016 e 08 em 2018). Conclusões: foi constatado que as doenças cardiovasculares representam uma parcela significante da população atendida nesse local. O diagnóstico precoce permite uma avaliação em tempo oportuno e mais acurada frente a necessidade de intervenção, constata-se a importância desse para que seja possível um tratamento adequado o mais breve possível e assim, permitir um melhor prognóstico permitindo uma sobrevida prolongada do indivíduo. Espera-se que esses dados contribuam para a reorientação de políticas públicas voltadas a promoção da saúde.
Cultivo de forragem hidroponica de inverno no ecótono cerrado pantanal
Authors: Santana Dthenifer Cordeiro , Arevalo Ana Caroline Mello , Silva Pablo Rozo , Kraeski Marcos Jefferson , Zanuncio Angelita dos Santos , Torres Francisco Eduardo 
Published: April 2020

A forragem hidropônica é uma alternativa para alimentar o animal em épocas de estiagem de maneira rápida. Deste modo o objetivo deste trabalho foi avaliar o desenvolvimento de forragem hidropônica de milho e milheto irrigados com soluções minerais e orgânica na época de inverno no ecótono Cerrado-Pantanal, buscando determinar a espécie e a solução mais adequada para região nessa época. O delineamento experimental foi em blocos casualizados, em esquema de parcelas subdividida. As parcelas foram as soluções (mineral e orgânica) e as subparcelas foram as populações de milho, milheto e mucuna preta e suas respectivas proporções totalizando 12 tratamentos, com quatro repetições. Na colheita foi realizada a avaliação de produção de massa verde e massa seca e procedeu-se a análise bromatológica da parte aérea e do substrato determinando-se proteína bruta, fibra detergente neutro, fibra detergente ácido e matéria mineral. Realizou-se a avaliação química da solução orgânica em laboratório de análise de solução de fertirrigação. A forragem de milho sob irrigação de solução mineral obteve melhores teores de proteína bruta. O substrato que obteve maior proteína bruta e menores teores de fibras foi na subparcela com 100% milheto para ambas soluções.
Efeitos do xadrez nas funções cognitivas e na aprendizagem de escolares: uma revisão sistemática
Authors: Rosa Rafaela Rossini , Uberti Letícia Bitencourt , Gubiani Marileda Barichello , Pagliarin Karina Carlesso 
Published: April 2020

Objetivo: Este estudo teve como objetivo revisar sistematicamente na literatura como o jogo de xadrez influencia as funções cognitivas e, consequentemente, o processo de aprendizagem na população escolar. Metodologia: Foram realizadas buscas nas bases de dados digitais PubMed, Scopus, SciELO e Lilacs, cujos critérios de elegibilidade selecionou estudos randomizados controlados e que a amostra abrangesse escolares entre 6:0 e 17:11 anos, sem comprometimento cognitivo, intelectual e/ou de aprendizagem. As buscas, seleção e análise dos artigos foram realizadas por dois avaliadores independentes. Resultados: Foram encontrados cinco estudos que relacionam jogo de xadrez com desempenho cognitivo e aprendizagem. Eles sugerem que o jogo de xadrez beneficia a cognição e a aprendizagem de escolares, mas divergiram quanto a significância deste benefício. Conclusão: Observou-se a necessidade de mais estudos da temática e de alta qualidade metodológica, principalmente relacionados à alunos com dificuldade de aprendizagem.
Preliminary evaluation and nutritional properties of Spondias mombin L. fruits from different native plants
Authors: Freitas Bheatriz Silva Morais de , Silva Richard Marins da , Cagnin Caroline , Cavalcante Maisa Dias , Soares Jackeline Cintra , Oliveira Filho Josemar Gonçalves de , Plácido Geovana Rocha 
Published: April 2020

The cajá fruit stands out for its peculiar flavor, but little is known about its physical, physical-chemical and nutritional characteristics. The knowledge of fruit and seed biometrics, physicochemical and nutritional composition provides information for the conservation and exploitation of resources of economic value, and can be exploited by genetic improvement programs to obtain cultivars that provide fruits with important characteristics for commercialization. Thus, it aimed to evaluate the characteristics we sought to evaluate these characteristics considering samples from different trees / regions of the municipality of Montes Claros of Goiás. The cajá fruit biometry (density, volume, mass, fruit and seed size and pulp yield) was measured. Titratable acidity, soluble solids content, pH, vitamin C content and mineral content were also measured. Total phenolic compounds and antioxidant activity were evaluated by the Folin-Ciocalteau, ORAC and ABTS methods, respectively. With the results obtained, it was possible to infer that the fruits harvested in different trees of different places differed statistically. The fruits of Region 2 had the highest fruit and seed length and diameter, as well as the highest pulp thickness, macro and micronutrient content and total phenolic compounds content, compared to fruit from other areas probably influenced by type of soil. The knowledge of the characteristics of the fruits from different trees / regions is necessary because the industrialization needs parameters for standardization in the formulation of different foods.
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS KOMPUTER MODEL TUTORIAL INTERAKTIF UNTUK MENINGKATKAN MOTIVASI BELAJAR SISWA PADA MATERI POKOK RELASI DAN FUNGSI
Authors: Dianta Yudi Jepri , Putri Ade 
Published: April 2020

The background of this research is the lack of a valid, practical and effective ICT-based learning media to learn about relations and functions. This research uses the Research and Development (R&D) method. The development model used in this study is the Plomp instructional model which consists of five phases namely: (1) the initial investigation phase; (2) the design phase; (3) realization phase; (4) test, evaluation and revision phases; (5) implementation phase. The purpose of this study is to develop ICT-based learning media on the subject of relations and functions that are valid, practical and efficient. The subjects of the study were 33 students of VIII grade SMP Negeri 5 Singingi Hilir. The instruments used were validation questionnaire, student response questionnaire and learning motivation questionnaire. Questionnaire sheets were analyzed quantitatively and qualitatively. Based on the results of data analysis, the developed media are in a very valid category, practical to use on learning about relations and functions and effective to increase student learning motivation.
Hormigón autocompactante utilizado en la construcción del arco del viaducto de Almonte
Authors: Cavero de Pablo Pedro 
Published: April 2020

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La elaboración y puesta en obra del hormigón del arco del Viaducto de Almonte requirió un estudio profundo y exhaustivo de más de un año de duración dado la particularidad del elemento a construir. En el artículo se repasa la cronología de ensayos y pruebas y se explican los diferentes factores y motivos en el camino recorrido hasta dar con la solución final.