bluuebunny/crossref_metadata_2025_split huggingface dataset:
An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients
Authors:   The NeuroLINCS Consortium, Ornelas Loren , Gomez Emilda , Panther Lindsay , Frank Aaron , Lei Susan , Mandefro Berhan , Banuelos Maria G , Shelley Brandon , Kaye Julia A , Lima Leandro , Wyman Stacia , Lim Ryan G , Wu Jie , Stocksdale Jennifer , Casale Malcolm , Dardov Victoria , Matlock Andrea , Venkatraman Vidya , Holewenski Ronald , Milani Pamela , Adam Miriam , Wassie Brook T , Cheng Andrew , Coyne Alyssa N , Daigle J. Gavin , Li Johnathan , Yang Stephanie , Cox Veerle , Wilhelm Mark , Lloyd Thomas E , Hayes Lindsey , Pham Jacqueline , Escalante-Chong Renan , Lenail Alex , Sachs Karen , Patel-Murray Natasha Leanna , Ramamoorthy Divya , Thompson Terri G ,   NYGC ALS Consortium, Finkbeiner Steven , Fraenkel Ernest , Rothstein Jeffrey D , Sareen Druv , Van Eyk Jennifer E , Svendsen Clive N , Thompson Leslie M. 
Published: November 2020

SummaryNeurodegenerative diseases present a challenge for systems biology, due to the lack of reliable animal models and the difficulties in obtaining samples from patients at early stages of disease, when interventions might be most effective. Studying induced pluripotent stem cell (iPSC)-derived neurons could overcome these challenges and dramatically accelerate and broaden therapeutic strategies. Here we undertook a network-based multi-omic characterization of iPSC-derived motor neurons from ALS patients carrying genetically dominant hexanucleotide expansions inC9orf72to gain a deeper understanding of the relationship between DNA, RNA, epigenetics and protein in the same pool of tissue. ALS motor neurons showed the expectedC9orf72-related alterations to specific nucleoporins and production of dipeptide repeats. RNA-seq, ATAC-seq and data-independent acquisition mass-spectrometry (DIA-MS) proteomics were then performed on the same motor neuron cultures. Using integrative computational methods that combined all of the omics, we discovered a number of novel dysregulated pathways including biological adhesion and extracellular matrix organization and disruption in other expected pathways such as RNA splicing and nuclear transport. We tested the relevance of these pathwaysin vivoin aC9orf72Drosophila model, analyzing the data to determine which pathways were causing disease phenotypes and which were compensatory. We also confirmed that some pathways are altered in late-stage neurodegeneration by analyzing human postmortem C9 cervical spine data. To validate that these key pathways were integral to the C9 signature, we prepared a separate set ofC9orf72and control motor neuron cultures using a different differentiation protocol and applied the same methods. As expected, there were major overall differences between the differentiation protocols, especially at the level of in individual omics data. However, a number of the core dysregulated pathways remained significant using the integrated multiomic analysis. This new method of analyzing patient specific neural cultures allows the generation of disease-related hypotheses with a small number of patient lines which can be tested in larger cohorts of patients.
Intestinal ferritinophagy is regulated by HIF-2α and is essential for systemic iron homeostasis
Authors: Das Nupur K , Sankar Amanda , Schwartz Andrew J , Solanki Sumeet , Ma Xiaoya , Parimi Sanjana , Santana-Codina Naiara , Mancias Joseph D. , Shah Yatrik M 
Published: November 2020

AbstractIron is critical for many processes including oxygen transport and erythropoiesis. Transcriptomic analysis demonstrates that HIF-2α regulates over 90% of all transcripts induced following iron deficiency in the intestine. However, beyond divalent metal transporter 1 (DMT1), ferroportin 1 (Fpn1) and duodenal cytochrome b (Dcytb), no other genes/pathways have been critically assessed with respects to their importance in intestinal iron absorption. Ferritinophagy is associated with cargo specific autophagic breakdown of ferritin and subsequent release of iron. We show here that nuclear receptor co-activator 4 (NCOA4)-mediated intestinal ferritinophagy is integrated to systemic iron demand via HIF-2α. Duodenal NCOA4 expression is regulated by HIF-2α during high systemic iron demands. Moreover, overexpression of intestinal HIF-2α is sufficient to activate NCOA4 and promote lysosomal degradation of ferritin. Promoter analysis revealed NCOA4 as a direct HIF-2α target. To demonstrate the importance of intestinal HIF-2α/ferritinophagy axis in systemic iron homeostasis, whole body and intestine-specific NCOA4-null mouse lines were assessed. These analyses demonstrate an iron sequestration in the enterocytes, and significantly high tissue ferritin levels in the dietary iron deficiency and acute hemolytic anemia models. Together, our data suggests efficient ferritinophagy is critical for intestinal iron absorption and systemic iron homeostasis.
Understanding influences on consumers’ dietary stress in healthy food buying
Authors: Hansen Torben , Thomsen Thyra Uth 
Published: November 2020

Purpose
This study aims to investigate relationships among body mass index (BMI), socioeconomic variables, dietary self-efficacy and consumer dietary stress in healthy food buying and explore whether different levels of personal values influence these relationships.

Design/methodology/approach
The study is based on an online representative cross-sectional study with 380 food consumers. Structural equation modeling served to estimate direct, mediating and moderating effects between the studied constructs and variables.

Findings
Examples of moderating and moderated mediating effects include a negative impact of BMI on dietary stress for consumers with low levels of enjoyment value but no significant effect for consumers with high levels of enjoyment. BMI also had a greater negative impact on dietary self-efficacy when the level of respect/achievement was high (vs low), and respect/achievement positively moderated the mediating effect of BMI on dietary stress through dietary self-efficacy.

Research limitations/implications
This study focuses on analyzing healthy food buying in a particular cultural setting and may suffer from a lack of generalizability to other cultures. The results suggest that research should take into account personal values when investigating stress.

Practical implications
Food managers and health authorities can improve their ability to reduce dietary stress when addressing consumers by understanding the role of personal values in healthy food choice and the impact on mental well-being.

Originality/value
This study offers a novel, more fine-grained conceptual model of how consumers develop dietary stress when buying healthy food.
Leadership practices of school principal through a distributed leadership lens: a case study of a secondary school in urban Pakistan
Authors: Nawab Ali , Asad Muhammad Mujtaba 
Published: November 2020

PurposeUnless the expertise of multiple teachers is availed, it is very unlikely for an individual leader to bring improvement especially at classroom level. This realization had led to the emergence of distributed leadership which is about engaging multiple individuals in leadership roles. The purpose of this study is to explore the role of school leadership in distributing leadership to teachers in a private secondary school in an urban context of Pakistan.Design/methodology/approachUsing qualitative approach and case study method, the research collects data from school leaders and teachers involved in leadership roles through interviews.FindingsIt was found that leadership facilitates distributed leadership through formulating a vision to develop teachers, enhancing the capacity of individuals involved in leadership roles, establishing a culture of trust, and creating opportunities for interaction and collaboration among teachers.Practical implicationsSchool leadership should distribute leadership to teachers in order to utilize the potential of multiple individuals which will ultimately lead to school improvement through initiatives from within. Educational reformers should incorporate the concept of distributed leadership in the professional development programmes designed for school leaders and teachers.Originality/valueThe study is first of its nature which reports on distributed leadership from a private sector school of Pakistan based on original data.
The sorcerer’s apprentice
Authors: Hirsch Peter Buell 
Published: November 2020

Purpose
The purpose of this paper is to illuminate the challenges of ad hoc teams in the corporate setting.

Design/methodology/approach
Review of the literature about teams, agile methodologies, scrums, etc. was carried out.

Findings
While ad hoc teams can create value, their proliferation has had unintended consequences.

Research limitations/implications
The literature review is, by its nature, selective not comprehensive.

Practical implications
Based on the recommendations cited, corporations will be able to make better decisions about when to initiate special teams.

Social implications
By doing so, companies will eliminate the frustrations employees feel in certain types of teams and improve their quality of life.

Originality/value
Although the subject of ad hoc teams has been extensively covered, this viewpoint takes a fresh look at the overall consequences of their proliferation.
The impact of semantic fluency on consumers' aesthetic evaluation in graphic designs with text
Authors: Deng Xun , Wang Liangyan 
Published: November 2020

PurposeThe purpose of this study is to examine the influence of semantic fluency on consumers' aesthetic evaluation in graphic designs with text and the mediating effect of visual complexity in this relationship.Design/methodology/approachThe hypotheses are examined in three experiments. Experiments 1 and 2 both verify that Chinese consumers rated the designs with low (vs high) semantic fluency words as more beautiful, and Experiment 3 further confirmed this effect in non-Chinese speakers.FindingsConfirmed by Chinese and non-Chinese consumers, high fluency text leads to lower perceived visual complexity and less aesthetic perception of the entire design.Research limitations/implicationsFindings enrich the theory of beauty standards and put forward challenges to the positive relationship between processing fluency and aesthetic pleasure. Findings are limited to the decorative function of text, and lack discussions on how designers should balance when the informational function of text is equally important.Originality/valueThis study is the first to discuss how designs with text influence consumers' aesthetic perception and provides meaningful guidelines of transnational marketing for fashion designers and enterprises.
An outline for an integrated language-sensitive approach to global work and mobility: cross-fertilising expatriate and international business and management research
Authors: Vulchanov Ivan Olav 
Published: November 2020

PurposeThe purpose of this conceptual literature review is to investigate how language factors have been studied in the expatriate literature, and how cross-fertilisation with the broader language-sensitive international business and management field may facilitate integrated research of language in global work.Design/methodology/approachThis paper is based on a thematic review of expatriate research and international business and management literature. The findings are structured through Reiche et al.'s (2019) three-dimensional conceptualisation of global work, after which two frameworks are developed to conceptualise how language connects the three dimensions – actors, structures and processes.FindingsThe literature review demonstrates that language-related topics are yet to gain status in the expatriate tradition, and the majority of studies, which do consider linguistic factors appear largely dissociated from the growing community of language research in the broader international management and international business fields. However, once consolidated, the literature reveals that language is present in all dimensions of global work. A processual view of corporate language management highlights the central role of human resource management (HRM), while a dynamic multi-level perspective indicates that language may form bidirectional relationships between the three dimensions of global work.Originality/valueDue to the segmentation between language-sensitive research in the expatriate and international business/management traditions, few studies have considered the HRM implications of global mobility and the multifaceted nature of language at work. This conceptual literature review brings both perspectives together for a more contextualised and holistic view of language in international workforces.
The role of client knowledge absorptive capacity for innovation in KIBS
Authors: Chichkanov Nikolay 
Published: November 2020

PurposeThis paper aims to study the relationship between the knowledge exchanged during client interactions and innovation in knowledge-intensive business services (KIBS) enterprises. It adapts the concept of absorptive capacity, i.e. the ability of the firm to successfully deal with external knowledge, to the case of client knowledge being absorbed with the support of information and communication technologies and explores whether its three main dimensions (acquisition, assimilation and application of client knowledge) are significant enablers of KIBS’ innovation propensity.Design/methodology/approachAn empirical analysis is based on a dataset of 417 Russian KIBS companies collected in 2019 following the recommendations suggested in the new edition of Oslo Manual. To examine the relationship between the three-client knowledge absorptive capacity dimensions and implementation of different types of innovation by KIBS, the study applies linear ordinary least squares and logistic regression methods.FindingsThe results show that acquisition of client knowledge through the wide number of digital channels, assimilation of such knowledge boosted by its codification through a digital customer relationship management (CRM) system and application of client knowledge across different functional areas are positively associated with both product and business process innovations in KIBS.Originality/valueThe paper proposes that KIBS should develop and sustain the strong internal capacity to absorb knowledge through routine day-to-day client interactions as a part of their knowledge management systems. The results also indicate that application of digital communication tools and CRM systems are beneficial for KIBS and increases their propensity to innovate.
The global trends of automated container terminal: a systematic literature review
Authors: Kon W.K. , Abdul Rahman Noorul Shaiful Fitri , Md Hanafiah Rudiah , Abdul Hamid Saharuddin 
Published: November 2020

Purpose
Since the first automated container terminal (ACT) was introduced at Europe Container Terminals Delta Terminal in Port Rotterdam back in the year 1992, a lot of research had been done to improve the management of ACT. However, up until recently, the number of literature available still appeared scarce. Hence, this paper aims to review the collection of literature about ACT to generate an exhaustive summary to answer the formulated review question in this study.

Design/methodology/approach
Preferred reporting items for systematic reviews and meta-analyses to narrow down the search parameters of literature retrieved so that only relevant articles were only selected. The systematic literature reviews were applied to analyse the content of the articles retrieved to determine its journal ranking, research findings and timeline of publications.

Findings
The adoption of ACT technology by container terminal operators could increase the terminal efficiency in productivity, cost reduction and environmental sustainability. Owing to global environmental awareness, the research trend of container terminal field and container terminal operator in the terminal design is much more environmentally friendly oriented.

Research limitations/implications
The limited numbers of experts in the management of ACT are causing challenges in data collections.

Practical implications
The analysis of the global ACT trend could help academicians and industrial investors to review the revolution timeline of maritime technology in port and shipping that is happening rapidly.

Originality/value
The analysis of timeline and collective literature leads to the propose of the conceptual framework to determine the relationship between increased productivity, cost reduction and environmentally sustainable.
Investigation of color and anticorrosive properties of pigments in the Fe-Al-Mg-O-H system by the simplex lattice method
Authors: Frolova Liliya , Butyrina Tatyana 
Published: November 2020

Purpose
The purpose of this paper is to study the patterns of formation of anti-corrosion properties, the development of compositions for pigments by using the method of co-precipitation and subsequent heat treatment.

Design/methodology/approach
To obtain co-precipitated hydroxides, aqueous solutions of salts were used. The conditions of synthesis varied according to the following parameters: the nature of the starting salts of metals; and the ratio of metal cations. The anticorrosive activity of the pigments was evaluated by the potentiodynamic method, by comparing the anodic and cathodic polarization curves, and calculated potentials and corrosion currents on the basis of regions of Tafel on curves. Polarization curves were obtained by using Potentiostat/Galvanostat/ZRA Gamry, which connected to the PC, and by using the program Gamry Framework. The measurement results were processed by using the method of simplex-lattice planning. X-ray diffractograms of pigments were recorded on a DRON – 2.0 diffractometer (monochromatic copper radiation with a nickel filter).

Findings
The paper deals with the results of research the dependence of colour characteristics and anticorrosion properties of synthesized compositions on their nature and composition. The presence of aluminium cations leads to the formation of solid solutions of ferrum and aluminium oxyhydroxides.

Originality/value
The main technological properties of pigments are determined by the anionic and cationic composition. Colour characteristics are determined by the cation-chromophore. The anti-corrosive properties of non-calcined pigments are determined to a greater extent by the presence of the formed hydroxyl ions and the composition of the compounds. The greatest protective effect is observed when using double compounds of metals, the dissociation constants of which differ significantly. The protective effect is mainly determined by the slowdown of the anode process. Anions containing aluminium atoms accelerate the corrosion processes.
Weathering in Detroit: Place, Race, Ethnicity, and Poverty as Conceptually Fluctuating Social Constructs Shaping Variation in Allostatic Load
Authors: GERONIMUS ARLINE T. , PEARSON JAY A. , LINNENBRINGER ERIN , EISENBERG ALEXA K. , STOKES CARMEN , HUGHES LANDON D. , SCHULZ AMY J. 
Published: November 2020

Policy Points
Despite 30 years of attention to eliminating population health inequity, it remains entrenched, calling for new approaches.
Targeted universalism, wellness‐based local development, and Jedi Public Health approaches that are community informed, evidence based, and focused on improving everyday settings and diverse lived experiences are important policy directions.
State and federal revenue transfers are necessary to mitigate the harms of austerity and assure greater equity in fiscal and population health in places like Detroit, Michigan.
ContextUS population health inequity remains entrenched, despite mandates to eliminate it. To promote a public health approach of consequence in this domain, stakeholders call for moving from risk‐factor epidemiology toward consideration of dynamic local variations in the physiological impacts of structured lived experience.MethodsUsing a community‐based, participatory research approach, we collected and analyzed a unique data set of 239 black, white, and Mexican adults from a stratified, multistage probability sample of three Detroit, Michigan, neighborhoods. We drew venous blood, collected saliva, took anthropometric measurements, and assayed specimens to measure allostatic load (AL), an indicator of stress‐mediated biological dysregulation, linking participants’ AL scores and survey responses. In a series of nested Poisson models, we regressed AL on socioeconomic, psychosocial, neighborhood, and behavioral stressors to test the hypothesis that race/ethnicity and poverty‐to‐income ratio (PIR) are conceptually fluctuating variables whose impacts on AL are sensitive to structured lived experience.FindingsWhite and Mexican Detroit participants with PIR < 1 have higher AL than counterparts nationally; black participants in Detroit and nationwide had comparable AL. Within Detroit, disparities by PIR were higher in whites than blacks, with no significant difference by PIR in Mexicans. The size of estimated effects of having PIR < 1 for whites is 58 percentage points greater than that of Mexicans and twice that of blacks.ConclusionsStructurally rooted unobserved heterogeneity bias threatens the validity of independent main effects interpretations of associations between race/ethnicity, socioeconomic characteristics, or place and health. One‐size‐fits‐all analytic or policy models developed from the perspective of the dominant social group insufficiently address the experiences of diverse populations in specific settings and historical moments; nor do they recognize culturally mediated protective resources residents may have developed against material and psychosocial hardship.
A Semi‐quantitative method for the detection of fentanyl using surface‐enhanced Raman scattering (SERS) with a handheld Raman instrument
Authors: Smith Matthew , Logan Mike , Bazley Mikaela , Blanchfield Joanne , Stokes Robert , Blanco Ana , McGee Rachel 
Published: November 2020

AbstractA handheld, spatially offset Raman spectroscopy (SORS) system was successfully used to obtain Surface‐enhanced Raman Scattering (SERS) spectra of fentanyl under simulated field conditions. A series of aqueous fentanyl solutions were prepared with commercially available gold nanoparticle solution, at concentrations ranging from 0.003 to 1697 μM. These SERS spectra were then used to generate two concentration calibration models (via a plot of peak area (1026 cm−1) versus concentration, and quantitative spectral decomposition using partial least squares (PLS1)). For both models, the relationship followed Langmuir adsorption and became non‐linear at concentrations above ~0.2 μM, with a limit of detection (LOD) of approximately 3 nM. The same technique was successfully used to measure fentanyl in the presence of two common “cutting agents,” heroin and glucose, at 1% and 2% fentanyl proportions (w/w). Fentanyl detection was successfully achieved, but mixture interference from the cutting agents prevented a calibration model being generated. Four fentanyl analogues were also investigated—butyrylfentanyl, furanylfentanyl, acetylfentanyl, and ocfentanyl. A concentration calibration model for each species was successfully generated, but differentiation from fentanyl proved more challenging, although several potential diagnostic peaks were identified. These results identified a pathway forward in using handheld equipment for the reliable detection of ultra‐low concentrations of fentanyl and fentanyl analogues via SERS, even when mixed with diluents. However, quantitative detection is negatively impacted in the presence of heroin and glucose. This also provides a starting point for a SERS‐based spectral library of fentanyl analogues, in combination with a range of different diluents.