bluuebunny/crossref_metadata_2025_split huggingface dataset:
Augmented immunosuppression and PTCY‐based haploidentical hematopoietic stem cell transplantation for thalassemia major
Authors: Vellaichamy Swaminathan Venkateswaran , Ravichandran Nikila , Ramanan Kesavan Melarcode , Meena Satish Kumar , Varla Harika , Ramakrishnan Balasubramaniam , Jayakumar Indra , Uppuluri Ramya , Raj Revathi 
Published: October 2020

AbstractAlternate donor HSCT for thalassemia major from a matched unrelated donor or haploidentical family donor is a feasible therapeutic option in children with no matched family donor. Aggressive pretransplant immunosuppression, reduced toxicity conditioning, and PTCY result in excellent thalassemia‐free survival. We describe here our experience in this cohort. We performed a retrospective analysis of the data on children who underwent a haploidentical HSCT for thalassemia major with PTCY at our center from August 2017 to August 2019. All children received pretransplant immune suppression for 6 weeks with fludarabine and dexamethasone, hypertransfusion and chelation with intravenous desferrioxamine. Conditioning included thiotepa, fludarabine, rabbit ATG, and cyclophosphamide, and GvHD prophylaxis included PTCY with tacrolimus. Twenty children were included and nineteen children engrafted. Acute hypertension occurred in five children, bacterial infection in eight children and viral respiratory infection in three children. Three children suffered from graft rejection. Reactivation of viruses namely CMV, adenovirus, and BK virus was seen in 60% of children. Grades 1‐2 acute GvHD of the skin in four children (20%) and limited chronic GvHD of the skin in four children (20%). Immune cytopenia was documented in three children (15%). Haploidentical HSCT offers a therapeutic option for children with thalassemia major with no suitably matched family or unrelated donors. Our reduced toxicity regimen with PTCY offers a DFS of 75% and OS of 95% with low transplant‐related mortality of 5%.
On Sylvia Wynter and feminist theory
Authors: Paquette Elisabeth 
Published: October 2020

AbstractThe goal of this study is to provide an account of the relation between feminist theory and the writings of decolonial theorist Sylvia Wynter. I offer a twofold approach to this account. On the one hand, I outline a series of texts that have addressed Wynter's critique of feminist theory. These authors note how Wynter problematizes a universal conception of woman that marginalizes women of color. On the other hand, I have provided an account of various authors who have turned to Wynter for the purpose of developing a feminist project. I make evident why it is the case that these two approaches are not contradictory or paradoxical in Wynter's work, but rather provide the foundation for a theory of liberation that is relevant to a variety of socio, geopolitical, and temporal locations.
Medial frontal negativities predict performance improvements during motor sequence but not motor adaptation learning
Authors: Matsuhashi Takuto , Segalowitz Sidney J. , Murphy Timothy I. , Nagano Yuichiro , Hirao Takahiro , Masaki Hiroaki 
Published: October 2020

AbstractAlterations in our environment require us to learn or alter motor skills to remain efficient. Also, damage or injury may require the relearning of motor skills. Two types have been identified: movement adaptation and motor sequence learning. Doyonet al. (2003, Distinct contribution of the cortico‐striatal and cortico‐cerebellar systems to motor skill learning. Neuropsychologia, 41(3), 252‐262) proposed a model to explain the neural mechanisms related to adaptation (cortico‐cerebellar) and motor sequence learning (cortico‐striatum) tasks. We hypothesized that medial frontal negativities (MFNs), event‐related electrocortical responses including the error‐related negativity (ERN) and correct‐response‐related negativity (CRN), would be trait biomarkers for skill in motor sequence learning due to their relationship with striatal neural generators in a network involving the anterior cingulate and possibly the supplementary motor area. We examined 36 participants' improvement in a motor adaptation and a motor sequence learning task and measured MFNs elicited in a separate Spatial Stroop (conflict) task. We found both ERN and CRN strongly predicted performance improvement in the sequential motor task but not in the adaptation task, supporting this aspect of the Doyon model. Interestingly, the CRN accounted for additional unique variance over the variance shared with the ERN suggesting an expansion of the model.
Negation, denial and falsity: Logic's negative trio
Authors: Hewitt Simon 
Published: October 2020

AbstractNegation, denial and falsity lie at the heart of debates about logic. We set out the classical account of the relationship between negation and denial, owing to Frege and Geach. We then challenge this on the basis that it does not permit an adequate account of falsity. A dialetheic alternative is minuted and criticised before a novel rejectivist account is proposed according to which falsity is the aim of the speech‐act of denial, whilst negation embeds deniability into assertoric contexts.
FoxA2 and p53 regulate the transcription of HSD17B1 in ovarian granulosa cells of pigs
Authors: Yuan Xiaolong , Zhou Xiaofeng , Qiao Xiwu , Wu Qi , Yao Zhixiang , Jiang Yao , Zhang Hao , Zhang Zhe , Wang Xilong , Li Jiaqi 
Published: October 2020

AbstractThe oestrogens have been highly implicated in the fertility of female animals. It is widely known that the oestrogens are primarily synthetized by the ovarian granulosa cells (GCs), and the final and essential step of this process is to catalyse the oestrone to the more active oestradiol by the protein coded by hydroxysteroid 17‐beta dehydrogenase 1 (HSD17B1) gene. However, the molecular mechanism regarding the transcription of HSD17B1 remains to be fully elucidated in ovarian GCs. In this study, the 5’‐deletion, luciferase assay and chromatin immunoprecipitation (ChIP) were utilized to explore the molecular regulation of transcription of HSD17B1 with the porcine ovarian GCs as the cellular model. After the deletions with −2105 to −1754 bp, −1753 to −1429 bp, −1430 to −1081 bp and −1082 to −730 bp, the relative luciferase activity of HSD17B1 promoter did not change significantly, but the deletion of −731 to −332 bp significantly increased the relative luciferase activity of HSD17B1 promoter, and an insertion (GTTT) that might raise the transcription of HSD17B1 was identified at −401 bp of HSD17B1. These findings suggested the region from −731 to +38 bp was the core promoter of HSD17B1, and the region between −731 to −332 bp might be a silence element for HSD17B1. Furthermore, the forkhead box A2 (FoxA2) directly bound at −412 to −401 bp to negatively but p53 bound at −383 to −374 bp to positively regulate the transcription and translation of HSD17B1 in ovarian GCs. These findings will improve our understanding on HSD17B1‐mediated oestrogens and provide useful information for further investigations into fertility of females.
A method for analyzing the expansion and shrinkage of point pattern
Authors: Sadahiro Yukio 
Published: October 2020

AbstractThis article proposes a new method for analyzing the spatial expansion and shrinkage of point patterns. Spatial expansions of epidemic diseases and market areas are represented as the expansions of point patterns when disease cases and store customers are represented as points. The spatial expansion and shrinkage have been studied in many scientific fields. Existing analytical methods, however, are not sufficient for treating complicated spatiotemporal patterns. To answer this demand, this article develops a new method for analyzing the expansion and shrinkage of points. Three vector measures evaluate the degree and direction of expansion and shrinkage as functions of location and time. They are visualized as vector maps, which are valid for capturing the global spatiotemporal pattern as well as for discussing the local variation. Summary measures of these vectors allow us to grasp the overall spatiotemporal pattern efficiently. To test the validity of the proposed method, this article applies it to the analysis of visitors to Shinjuku and Ginza in Tokyo. The proposed measures permitted us to evaluate the spatiotemporal pattern of the visitors in detail and to consider its underlying structure from various perspectives, which indicated the soundness of the technique.
Love the ones you’re with: Characteristics and behaviour of Maryland pets and their owners in relation to tick encounters
Authors: de Wet Sara , Rutz Heather , Hinckley Alison F , Hook Sarah A , Campbell Stefanie , Feldman Katherine A 
Published: October 2020

AbstractWe conducted a cross‐sectional study to evaluate associations between pet characteristics and behaviours and risk of tick encounters among pets and pet owners. We defined a tick encounter as ticks found crawling on or attached to a pet or pet owner. Information about pet characteristics, interactions between owners and pets, and tick encounters were captured through an online survey. Associations were evaluated using univariate and multivariable analyses. In univariate analysis, walking dogs only on pavement reduced risk of tick encounter among owners (prevalence ratio (PR) = 0.51, 95% confidence interval (CI): 0.30, 0.84). Having a dog or cat that hunted small animals increased risk of tick encounter among owners (PR = 1.66, 95% CI: 1.30, 2.13; PR = 1.57, 95% CI: 1.05, 2.34, respectively). No direct interactions between owners and pets (e.g., pets sleeping on owners' beds) were associated with increased risk of tick encounters among owners. In multivariable analysis among dog owners, having a pet with a tick encounter within the last six months was associated with increased risk of owner tick encounter (adjusted odds ratio (aOR) = 4.17, 95% CI: 2.94, 5.92); in addition, having a dog that hunts small animals was associated with increased risk of owner tick encounter (aOR = 1.97, 95% CI: 1.25, 3.11). These results suggest that the location of pet‐owner interactions may be more important than the type of interactions. Pet owners should avoid tick habitat with pets; when that is not possible, proper use of tick preventive products for pets, wearing repellents by owners and conducting tick checks for both pets and owners is critical for prevention of tick encounters and tick‐borne disease.
PEDOT:PSS Coating Improves Gecko-Inspired Adhesive Performance
Authors: Kerst Capella , Suresh Srinivasan A. , Ferro Marc , Cutkosky Mark 
Published: October 2020

Abstract
We report a surface treatment for an elastomeric dry adhesive that improves adhesion, especially on surfaces with microscopic roughness. The process involves coating wedge-shaped polydimethylsiloxane (PDMS) features of the adhesive with a 50 nm coating of poly (3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS). As compared to the uncoated adhesive, performance is 1.25× better on smooth surfaces like glass, with a maximum shear stress of 70 kPa in shear and 25 kPa in normal adhesion under controlled loading conditions. On slightly rough surfaces such as paper and panels painted with flat paint, it provides between 2.5× and over 12× greater shear stress than the uncoated adhesive. Moreover, the coating, being much stiffer than the underlying wedges, does not increase the tendency to become dirty and does not tend to self-stick, or clump. Durability tests show that the performance remains substantially unchanged for 80,000 attachment/loading/detachment cycles. We describe the coating process, present the test results, and discuss the reasons for the enhanced performance on a variety of materials.
Discrete-Time Nonlinear Singularly Perturbed System Identification Using Coupled Multimodel Representation
Authors: Ben Rajab Asma , Bahri Nesrine , Ltaief Majda 
Published: October 2020

Abstract
Many control and observability theories for singularly perturbed systems require the full knowledge of system model parameters exceptionally if the system is considered as black box. To overcome this problem and to obtain an accurate and faithful model, this paper describes a new identification method for discrete-time nonlinear singularly perturbed systems (NLSPS) using the coupled state multimodel representation. The Levenberg–Marquardt algorithm is used to identify not only the submodels parameters but also the perturbation parameter ε. Two cases are considered to identify these systems. The first one supposes that the perturbation parameter ε of the real system is known and thus only the submodels parameters are identified. The second case supposes that this perturbation parameter is unknown and has to be identified with the other submodels parameters. The simulation example demonstrates the effectiveness of the proposed identification.
Anisotropic Effect on Ductile Crack Growth of Pressurized Pipes Under Fully Bending Moment
Authors: Sakonder Cuneyt , Paredes Marcelo 
Published: October 2020

Abstract
One of the common assumptions done in Engineering Critical Assessment (ECA) procedures and standard design codes to assess criticality of initial defects is that the metallic material is isotropic and its plastic flow can be well represented by the von Mises yield function for large plastic deformations. This is due to the coupons used for material characterization are usually extracted from the pipe section along a specific orientation (transverse or longitudinal), and thus the material is deemed as isotropic. This factor may limit tremendously the applicability of the ECA for a more general loading case scenario, where the criticality of the initial crack would be required. In this exploratory study, a X65 seam weld pipeline steel is investigated by considering the effect of anisotropy on plasticity and fracture responses of biaxially loaded pipes having different crack lengths, diameter sizes and internal hydrostatic pressures. The results indicate that anisotropic effects become significant in thin-walled pipes than in thicker configurations regardless initial crack size and internal pressure due to the heavy wall-thickness.
Failure Pressure Prediction of Crack in Corrosion Defects in 2D by Using XFEM
Authors: Zhang Xinfang , Okodi Allan , Tan Leichuan , Leung Juliana , Adeeb Samer 
Published: October 2020

Abstract
Aging pipelines may experience several different types of degradation, such as crack and corrosion, which pose serious concerns for the pipeline integrity. Hybrid flaws such as crack-in-corrosion (CIC), can be challenging to model and understand. For instance, predicting the failure pressure using the finite element method (FEM) is relatively difficult; therefore, the extended finite element method (XFEM) is introduced here. Compared to the conventional FEM, which requires extremely fine meshes and is impractical for modelling dynamic crack propagation, XFEM is computationally efficient as there is no need to update the mesh elements for tracking the crack path. This paper aims to study the applicability of XFEM in predicting the failure pressure of CIC defects in 2D. In particular, mesh size sensitivity and the effects of different CIC parameters on the final failure pressure were examined. ABAQUS v 6.14 was used for this simulation study. For simplicity, only half of the pipe was modelled assuming symmetry around the horizontal plane. A CIC defect was placed at the exterior of the pipe. The corroded area was assumed to be semi-elliptical, and the crack was simulated as a longitudinal crack. In this paper, failure criterion was satisfied when the crack has propagated to the last element. Several models were built in which the length and width of the elements at the crack tip were changed. An optimum mesh size was determined and was applied subsequently in several other models to study the impacts of crack depths, corroded area widths, and corrosion profiles. The results showed that when the total defect depth was fixed at 50% of the wall thickness, the failure pressure decreased with increasing the crack depth, while both corroded area width and corrosion profile only have a secondary effect on the failure pressure. In addition, the failure pressure of a CIC defect was bound between that of a crack-only defect and a corrosion-only defect. When the depth of the crack is higher than 50% of the total defect area, the CIC defect can be treated as a crack only defect with a crack depth equal to the total defect depth.
A Finite Element Simulation Study on Reducers Based on Ultrasonic Guided Waves
Authors: Pu-Gen Zhang , Ju Ding , Yu-Qing Yang , Jin-Sha Xu , Jin-Feng Lin 
Published: October 2020

Abstract
Due to its special structural form, the reducers have common corrosion defects such as corrosion thinning, cracks and so on after being strongly impacted by the medium inside the pipes. However, there are few studies on the detection of reducers with the help of ultrasonic guided waves at present. In order to explore the effect of reducers to ultrasonic guided waves detection, the propagation characteristics of ultrasonic guided waves in reducer were simulated by using ABQUES. In the simulation, L (0, 2) mode was used to detect the reducer by two set of experiments. The first set of simulation experiment, L (0, 2) mode was excited from the large end of the pipe to detect the pipe with axial crack, circumferential crack and no crack respectively. The second set of simulation experiment, L (0, 2) mode was excited from the small end of the pipe to detect the pipe with axial crack, circumferential crack and no crack. The ability to detect defect was assessed by the time domain waveform of reflected echo, and the dynamic stress distribution cloud map is used to visually explain the propagation characteristics of the guided waves passing through the reducer, and the difference of detection capability between the two ends of excitation is judged by comparing the detection results. The conclusion shows that it is more sensitive to detect defect when ultrasonic guided waves are excited at the larger end, the ability to detect defects is weak when ultrasonic guided waves are excited at the small end. The mode conversion occurs and generate F (1, 1) mode, when the guided waves pass through the reducer from both ends. This paper provides effective technical guidance when ultrasonic guided waves detect defect on reducers.
Research on Flexible Phased Array Technique for Testing the Inserted Fillet Welds
Authors: Qian Shengjie , Chen Hu , Xu Shengyong , Chen Dingyue 
Published: October 2020

Abstract
It is difficult to guarantee the welding quality of inserted fillet welds because of its special geometry and complicated stress condition. For the low detection efficiency of the conventional ultrasonic testing method, the false detection and the missed detection of the flaws occur frequently. For the above reasons, a new testing method is presented in this paper which based on the common structure characteristics of inserted fillet welds. The key point of this new method is to put the flexible phased array on the internal surface of the tube during the detection. The beam focusing model of flexible phased array is theoretically analyzed. The simulation on the acoustic field and defect response with CIVA software are completed to determine the phased array parameters, including array elements, array element size, deflection angle, ultrasonic frequency and so on. Then, a special ultrasonic detection system is designed and fabricated for testing the inserted fillet welds. In addition, the specimen of the inserted fillet welds with artificial flaws is manufactured and experiment research is carried out. Finally, the quality detection of actual product is successfully implemented. The results indicate that this technique can effectively detect the typical flaws such as crack, slag, porosity, etc.
Significance of Ms and Validation of Reference Stress Solutions for Crack Like Flaws: Part 2
Authors: Ishizaki Yoichi , Thorwald Greg , Yonekawa Futoshi 
Published: October 2020

Abstract
This is Part 2 of two papers discussing the significance of two key factors of crack like flaw assessment in the Fitness for Service assessment.
While FEM analysis technology has been advancing amazingly in recent years, and FEM based fitness-for-service assessment of a damaged components, such as crack like flaws and local metal loss assessment, has become mainstream in assessments, it is still important to understand the reference stress solution based on a limit load analysis and the role of each factor in the failure mode to control the damaged component safely until the end of its life.
In API 579-1/ASME FFS-1[1], Part 9, Assessment of Crack like Flaws, those reference stress solutions were developed based on the limit load analysis using Folias factor Mt and surface correction factor Ms. Folias factor Mt and surface correction factor Ms, are factors that account for the bulging effect around flaws. Those factors enable prediction of a maximum allowable pressure of a damaged cylindrical shell from a simple flat plate model that contain same size of a damaged area.
As for Folias factor, Mt, it is well known to express the relationship between the reference stress of a through-wall crack flat plate and a through-wall crack cylinder. The application of Mt is clearly defined in ASME/API 579 FFS-1 part 9C, as well as papers by Folias et al. The the significance of the surface correction factor for surface flaw, Ms, has not been commonly understood well enough in general. Unfortunately, API 579-1/ASME FFS-1 also does not clearly mention its significance and how Ms is to be applied in the stress analysis. At a glance, Ms looks like a similar factor to Mt, and it is tempting to simply apply Ms to primary membrane stress term like Mt, but that is not correct. Eventually, an incorrect application of Ms would lead to an incorrect discussion of a flaw characterization. Often, there is a question about ASME/API 579 FFS-1 Part 9C reference stress solutions, especially for ASME/API 579 FFS-1 eq. 9C.76, from the misunderstanding meaning of the Ms factor. Addressing this issue is important to maintain the integrity of the Fitness-For-Service technology.
In this Part 2 of two papers, validation of equations obtained in Part 1 are discussed and proven based on FEM analysis.
Structural Evaluation With Elastic and Inelastic Analysis Methods on a High Temperature Storage Tank Subjected to Static and Dynamic Loadings
Authors: Wang Wen , Zhang Xiaochun , Wang Xiaoyan , Cai Maoyuan 
Published: October 2020

Abstract
The structural integrity of reactor components is very essential for the reliable operation of all types of power plants, especially for components operating at elevated temperature where creep effects are significant and where components are subjected to high-temperature alteration and seismic transient loading conditions. In this article, a molten salt storage tank in high temperature thorium molten salt reactor (TMSR) is evaluated according to ASME-III-5-HBB high temperature reactor code. The evaluation based on 3D finite element analyses includes the load-controlled stress, the effects of ratcheting, and the interaction of creep and fatigue. The thermal and structural analysis and the application procedures of ASME-HBB rules are described in detail. Some structural modifications have been made on this molten salt storage tank to enhance the strength and reduce thermal stress. The effects of ratcheting and creep-fatigue damage under elevated temperature are investigated using elastic analysis and inelastic analysis methods for a defined representative load cycle. In addition, the strain range and the stress relaxation history calculated by elastic and inelastic methods are compared and discussed. The numerical results indicate that the elastic analysis is conservative for design and a full inelastic analysis method for estimating input for creep-fatigue damage evaluation need to be developed.