bluuebunny/crossref_metadata_2025_split huggingface dataset:
RAPID-ADPKD (Retrospective epidemiological study of Asia-Pacific patients with rapId Disease progression of Autosomal Dominant Polycystic Kidney Disease): study protocol for a multinational, retrospective cohort study
Authors: Ryu Hyunjin , Park Hayne C , Oh Yun Kyu , Sangadi Irene , Wong Annette , Mei Changlin , Ecder Tevfik , Wang Angela Yee-Moon , Kao Tze-Wah , Huang Jenq-Wen , Rangan Gopala K , Ahn Curie 
Published: February 2020

IntroductionPatients with autosomal dominant polycystic kidney disease (ADPKD) reach end-stage renal disease in their fifth decade on average. For effective treatment and early intervention, identifying subgroups with rapid disease progression is important in ADPKD. However, there are no epidemiological data on the clinical manifestations and disease progression of patients with ADPKD from the Asia-Pacific region.Methods and analysisThe RAPID-ADPKD (Retrospective epidemiological study ofAsia-Pacific patients with rapIdDisease progression ofAutosomalDominantPolycysticKidneyDisease) study is a multinational, retrospective, observational cohort study of patients with ADPKD in the Asia-Pacific region (Australia, China, Hong Kong, South Korea, Taipei and Turkey). This study was designed to identify the clinical characteristics of patients with ADPKD with rapid disease progression. Adult patients with ADPKD diagnosed according to the unified ultrasound criteria and with an estimated glomerular filtration rate (eGFR) ≥45 mL/min/1.73 m2at baseline will be included. The cohort will include patients with ≥2 records of eGFR and at least 24 months of follow-up data. Demographic information, clinical characteristics, comorbidities, medications, eGFR, radiological findings that allow calculation of height-adjusted total kidney volume, ADPKD-related complications and the Predicting Renal Outcomes in autosomal dominant Polycystic Kidney Disease (PRO-PKD) score will be collected. Rapid progression will be defined based on the European Renal Association – European Dialysis and Transplant Association (ERA-EDTA) guideline. All other patients without any of these criteria will be classified to be of slow progression. Clinical characteristics will be compared between patients with rapid progression and those with slow progression. The incidence of complications and the effects of race and water intake on renal progression will also be analysed. The planned sample size of the cohort is 1000 patients, and data from 600 patients have been collected as of 30 May 2019.Ethics and disseminationThis study was approved or is in the process of approval by the institutional review boards at each participating centre. The results will be presented in conferences and published in a journal, presenting data on the clinical characteristics, risk factors for disease progression and patterns of complications of ADPKD in Asian populations.
Effects of switching from a dipeptidyl peptidase-4 inhibitor to luseogliflozin on nocturnal blood pressure in patients with type 2 diabetes: protocol for a multicentre, prospective, randomised, open-label, blinded endpoint parallel-group comparison study
Authors: Kameda Reina , Nomoto Hiroshi , Cho Kyu Yong , Kawata Shinichiro , Omori Kazuno , Takeuchi Jun , Nagai So , Kurihara Yoshio , Aoki Shin , Nakamura Akinobu , Atsumi Tatsuya , Miyoshi Hideaki 
Published: February 2020

IntroductionNocturnal hypertension is clinically important for patients with type 2 diabetes (T2D), considering its strong correlation with cardiovascular events. We aim to test the hypothesis that the sodium-glucose cotransporter 2 inhibitor, luseogliflozin, ameliorates nocturnal hypertension more effectively than a dipeptidyl peptidase (DPP)-4 inhibitor in patients with T2D.Methods and analysisThis study is a multicentre, prospective, randomised, open-label, blinded endpoint parallel-group trial. Sixty participants with T2D and hypertension who have been treated with a DPP-4 inhibitor for more than 4 weeks and who have a glycated haemoglobin A1c (HbA1c) level of 6.0%–9.0% will be randomised based on age, body mass index (BMI) and HbA1c to continue taking their DPP-4 inhibitor or to switch to luseogliflozin 2.5 mg once daily for 8 weeks. Twenty-four-hour ambulatory blood pressure monitoring (ABPM) will be performed twice at baseline and at the end of the study. All participants will continue their diet and exercise therapy, and the doses of concomitant medications will not be adjusted during the study. The primary endpoint is the effect of luseogliflozin on the mean change in systolic blood pressure (SBP) during the night, as measured by ABPM. The secondary endpoints are mean change in diastolic blood pressure (DBP) during the night, 24 hours of SBP and DBP, daytime SBP and DBP, pulse rate, BP M-value, trough SBP and DBP for 1 hour before the next dose, and other laboratory parameters. The sample size was calculated for a two-sided test at 90% power for the detection of a difference between treatments.Ethics and disseminationThe Ethics Review Board of Hokkaido University Hospital has approved the protocol. The results will be disseminated in peer-reviewed journals and at scientific conferences.Trial registration numbersThe University Hospital Medical Information Network (UMIN000031451); Japan Registry of Clinical Trials (jRCTs011180019); Pre-results.
Enhancing feedback on performance measures: the difference in outlier detection using a binary versus continuous outcome funnel plot and implications for quality improvement
Authors: Kuhrij Laurien , van Zwet Erik , van den Berg-Vos Renske , Nederkoorn Paul , Marang-van de Mheen Perla J 
Published: February 2020

BackgroundHospitals and providers receive feedback information on how their performance compares with others, often using funnel plots to detect outliers. These funnel plots typically use binary outcomes, and continuous variables are dichotomised to fit this format. However, information is lost using a binary measure, which is only sensitive to detect differences in higher values (the tail) rather than the entire distribution. This study therefore aims to investigate whether different outlier hospitals are identified when using a funnel plot for a binary vs a continuous outcome. This is relevant for hospitals with suboptimal performance to decide whether performance can be improved by targeting processes for all patients or a subgroup with higher values.MethodsWe examined the door-to-needle time (DNT) of all (6080) patients with acute ischaemic stroke treated with intravenous thrombolysis in 65 hospitals in 2017, registered in the Dutch Acute Stroke Audit. We compared outlier hospitals in two funnel plots: the median DNT versus the proportion of patients with substantially delayed DNT (above the 90th percentile (P90)), whether these were the same or different hospitals. Two sensitivity analyses were performed using the proportion above the median and a continuous P90 funnel plot.ResultsThe median DNT was 24 min and P90 was 50 min. In the binary funnel plot for the proportion of patients above P90, 58 hospitals had average performance, whereas in the funnel plot around the median 14 of these hospitals had significantly higher median DNT (24%). These hospitals can likely improve their DNT by focusing on care processes for all patients, not shown by the binary outcome funnel plot. Similar results were shown in sensitivity analyses.ConclusionUsing funnel plots for continuous versus binary outcomes identify different outlier hospitals, which may enhance hospital feedback to direct more targeted improvement initiatives.
Sociodemographic Correlates of Food Insecurity Among New York City Tobacco Users
Authors: Wysota Christina N. , Sherman Scott E. , Vargas Elizabeth , Rogers Erin S. 
Published: February 2020

Purpose: To identify rates and sociodemographic correlates of food insecurity among low-income smokers. Design: Cross-sectional analysis of baseline survey data from a randomized controlled trial (N = 403) testing a smoking cessation intervention for low-income smokers. Setting: Two safety-net hospitals in New York City. Sample: Current smokers with annual household income <200% of the federal poverty level. Measures: Food insecurity was measured using the United States Department of Agriculture 6-item food security module. Participant sociodemographics were assessed by self-reported survey responses. Analysis: We used frequencies to calculate the proportion of smokers experiencing food insecurity and multivariable logistic regression to identify factors associated with being food insecure. Results: Fifty-eight percent of participants were food insecure, with 29% reporting very high food insecurity. Compared to married participants, separated, widowed, or divorced participants were more likely to be food insecure (adjusted odds ratio [AOR] = 2.33, 95% confidence interval [CI]: 1.25-4.33), as were never married participants (AOR = 2.81, 95% CI: 1.54-5.14). Conclusions: Health promotion approaches that target multiple health risks (eg, smoking and food access) may be needed for low-income populations. Interventions which seek to alleviate food insecurity may benefit from targeting socially isolated smokers.
Rapid ecosynthesis of TiO2@CuO@Chromite nanocatalyst for environmentally friendly applications: solventless cyanation of aldehydes and high efficient treatment of sewage waters
Authors: Sajadi S. Mohammad , Pirouei Mohammad , Salih Nabaz A. , Kolo Kamal , Hamad Samir M. 
Published: February 2020

Abstract
Background
Due to the large surface area of green-synthesized TiO2@CuO@Chromite nanocatalysts (NCs) and accumulations of bioactive phytochemicals on its surface, it was used for an efficient and safe synthesis of nitriles and also an environmentally friendly process of water treatment. For the first time, a rapid, economic, one-pot, solventless and safe protocol is presented for ecosynthesis of TiO2@CuO@Chromite nanocatalysts (NCs) to efficient, ligand-free and solventless synthesis of aromatic nitriles through the cyanation of aldehydes at room temperature. Furthermore, the eco-NCs were used as a potent adsorbent for physical and biological treatment of sewage waters collected around the natural and residential area of northern parts of the Soran city in Iraq at room temperature.

Results
The structural elucidation of the NCs using the SEM (scanning electron microscopy), Cross-sectional EDS (electron dispersive spectroscopy), elemental mapping analysis, XRD (X-ray diffractions) and BET (Brunauer–Emmett–Teller) for detection of specific surface area of eco-NCs confirmed the formation of NCs with a large surface area. Application of green TiO2@CuO@Chromite NCs in solventless synthesis of aromatic nitriles shows high efficiency, time saving, economical aspect and ecofriendly and safe methodology. Also, the treatment process of sewage waters monitored using UV–Vis double beam spectrophotometer, optical microscopy and antibiogram tests demonstrated an efficient ability for the eco-NCs in physical and biological treatment of sewage samples.

Conclusions
The NCs employed in both ligand and solventless highly efficient and safe synthesis of aromatic nitriles through the cyanation of aldehydes at room temperature demonstrated the production of aryl nitriles in very good-to-excellent yields. This protocol indicated a green alternative to the existing methods since the reaction proceeds in solventless medium in the absence of any ligand and organic solvent with simple work-up procedure, low temperature, higher yield and shorter reaction time. Further, it was used in the physical and biological treatment of the real samples of sewage waters collected around the natural and residential area of northern parts of Iraq at room temperature, which shows a very good treatment ability in this process.
Skeletal muscle as an experimental model of choice to study tissue aging and rejuvenation
Authors: Etienne Jessy , Liu Chao , Skinner Colin M. , Conboy Michael J. , Conboy Irina M. 
Published: February 2020

AbstractSkeletal muscle is among the most age-sensitive tissues in mammal organisms. Significant changes in its resident stem cells (i.e., satellite cells, SCs), differentiated cells (i.e., myofibers), and extracellular matrix cause a decline in tissue homeostasis, function, and regenerative capacity. Based on the conservation of aging across tissues and taking advantage of the relatively well-characterization of the myofibers and associated SCs, skeletal muscle emerged as an experimental system to study the decline in function and maintenance of old tissues and to explore rejuvenation strategies. In this review, we summarize the approaches for understanding the aging process and for assaying the success of rejuvenation that use skeletal muscle as the experimental system of choice. We further discuss (and exemplify with studies of skeletal muscle) how conflicting results might be due to variations in the techniques of stem cell isolation, differences in the assays of functional rejuvenation, or deciding on the numbers of replicates and experimental cohorts.
Multimodal transport information sharing platform with mixed time window constraints based on big data
Authors: Ding Liqun 
Published: February 2020

AbstractThe primary consideration in the top-level design of multimodal transport systems is the matching degree and coordination degree of port facilities and transport information platforms. In the process of container transportation, there exists a mixed time window consisting of a hard time window and a soft time window. This study focuses on the coordination of transport organization considering the scale effect under the constraint of a mixed time window. It is necessary to consider the influence of the mixed time window on transport efficiency. Highway transportation is relatively flexible and can be regarded as without time window constraints. Railway transportation and waterway transportation have relatively fixed delivery and operation times, reflecting hard time windows. Alternatively, the time interval of a consignee receiving goods is relatively free, reflecting a soft time window. The process of container transportation involves a mixed time window consisting of a hard time window and a soft time window. The scale effect of transportation is the result of a combination of internal and external factors. This paper will discuss the functions and operational statuses of the relatively independent information system of railways and ports and establish an electronic platform suitable for information interconnection and the interoperability of multimodal transport stations in combination with the traditional information exchange mode.
Development of E-banking channels and market share in developing countries
Authors: Nazaritehrani Ali , Mashali Behzad 
Published: February 2020

AbstractThere is fierce global competition within the banking industry. Therefore, banks endeavor to grow and strive to increase their market share. We analyzed the effect of developing innovative channels of presenting bank services on banks’ market share. The statistical population of this research was Shahr bank’s central headquarter and its branches in Tehran, Iran. We developed questionnaires for gathering the data. The validity and reliability of the scales were tested by EFA, CFA, experts’ opinion, and Cronbach’s alpha. We used linear regression to assess the impact of innovative channels, including internet banking, automatic teller machines (ATMs), mobile banking, telephone banking (TB), and point of sales (POS) on banks’ market share. The results indicated that some of these channels, including internet banking, POS, and TB, positively affect a bank’s market share. The effect of two other platforms, including mobile banking and ATM development, on banks’ market share was rejected. The findings of this study expand our understanding of how bank managers can improve their market share by developing innovative e-banking channels.
Prevalence of inherited changes of uric acid levels in kidney dysfunction including stage 5 D and T: a systematic review
Authors: Shamekhi Amiri Fateme , Rostami Zohreh 
Published: February 2020

Abstract
Background/aims
Familial juvenile hereditary nephropathy (FJHN) is characterized by hyperuricemia due to severely impaired urinary excretion of urate. Hereditary renal hypouricemia is an inborn error of membrane transport. Because studies of inherited tubulopathy is rare, prevalence and diagnosis of these inherited tubulopathy increase with genetic testing.The aim of this study is to investigate prevalence of clinical features, biochemical profiles, and genetic analysis of patients with changes in serum uric acid levels in inherited tubulopathy.

Main body
The paper has written based on searching PubMed and Google Scholar to identify potentially relevant articles or abstracts. In this retrospective study, a total 65 patients with changes of serum uric acid levels and kidney dysfunction were investigated. Clinical features, laboratory data at initial presentation, management, and outcomes were collected. Forty studies (65 participants) included in this review. The mean ± SD of age of study patients in inherited tubulointerstitial kidney disease was 25.29 ± 14.69 years. Mean ± SD age of patients at time of diagnosis in inherited renal hypouricemia was 18.83 ± 10.59 years. Correlation between exon region in mutated UMOD, SLC22A12, and SLC2A9 genes and serum uric acid levels were assessed and revealed significant statistical correlation between exon region of SLC2A9 mutation and serum uric acid levels. Prevalence of progression to end-stage kidney disease in patients with inherited tubulointerstitial kidney disease and inherited renal hypouricemia were assessed 20% and 2.5%, respectively. There was nephrolithiasis in two patients (2/25, 8%) with inherited renal hypouricemia.

Conclusions
This study shows that UMOD and SLC22A12 gene mutations were responsible for majority of autosomal-dominant tubulointerstitial kidney disease and inherited renal hypouricemia, respectively.
A critical review of self-care for sleep disturbances: prevalence, profile, motivation, perceived effectiveness and medical provider communication
Authors: Meredith Sophie , Frawley Jane , Sibbritt David , Adams Jon 
Published: February 2020

Abstract
Objective
This study aims to undertake the first critical review of self-care use among adults with sleep disturbances by focusing on the prevalence of self-care—the self-determined and self-administered use of products or practices—by adults with sleep disturbances.

Methods
A comprehensive search of 2006–2016 international literature in CINAHL, AMED, Medline and EMBASE databases was conducted. The search was confined to empirical research findings regarding sleep disturbances - as indicated by a validated sleep scale/index or clinician diagnosis.

Results
Of the 21 articles included in this review, only three reported on sleep disturbances other than insomnia disorder (ID) or insomnia symptoms (IS). Overall, a high prevalence of self-care use is reported among adults with sleep disturbances, particularly for ID and IS. Self-care products and practices are more likely to be used by adults with sleep disturbances, than those without sleep disturbances. Commonly used self-care products and practices include OTC hypnotics, antihistamines, diphenhydramine products, diet, exercise, painkillers, herbal medicines, vitamins, minerals and dietary supplements, yoga, tai chi, Qigong, meditation, exercise and relaxation.

Conclusions
Many adults with sleep disturbances–particularly ID or IS–frequently use self-care products and practices. Self-care products are also used concomitantly with conventional prescription medications without disclosure to medical professionals. The current literature is of varied methodological caliber, frequently relies on small sample sizes and low-quality data collection therefore further rigorous health services research is required. There is an especial paucity of data regarding self-care for sleep disturbances such as restless legs syndrome and obstructive sleep apnea. Healthcare providers may find it beneficial to actively ask patients about their use of self-care for sleep disturbances to help avoid harmful drug-drug or drug-herb interactions.
7-T clinical MRI of the shoulder in patients with suspected lesions of the rotator cuff
Authors: Lazik-Palm Andrea , Kraff Oliver , Rietsch Stefan H. G. , Ladd Mark E. , Kamminga Michael , Beck Sascha , Quick Harald H. , Theysohn Jens M. 
Published: February 2020

Abstract
Background
To evaluate feasibility and diagnostic performance of clinical 7-T magnetic resonance imaging (MRI) of the shoulder.

Methods
Eight patients with suspected lesions of the rotator cuff underwent 7-T MRI before arthroscopy. Image quality was scored for artifacts, B1+ inhomogeneities, and assessability of anatomical structures. A structured radiological report was compared to arthroscopy. In four patients, a visual comparison with pre-existing 1.5-T examinations was performed.

Results
Regarding image quality, the majority of the sequences reached values above the middle of each scoring scale. Fat-saturated proton density sequences showed least artifacts and best structure assessability. The most homogenous B1+ field was reached with gradient-echo sequences. Arthroscopy did not confirm tendinopathy/partial tear of supraspinatus in 5/8 patients, of subscapularis in 5/6, and of infraspinatus in one patient; only a partial lesion of the subscapularis tendon was missed. Pathologic findings of long bicipital tendon, acromioclavicular joint, glenohumeral cartilage, labrum, and subacromial subdeltoideal bursa were mainly confirmed; exceptions were one lesion of the long bicipital tendon, one subacromial bursitis, and one superior glenoid labrum anterior-to-posterior lesion, missed on 7-T MRI. Evaluating all structures together, sensitivity was 86%, and specificity 74%. A better contrast and higher image resolution was noted in comparison to previous 1.5-T examinations.

Conclusions
7-T MRI of the shoulder with diagnostic image quality is feasible. Overrating of tendon signal alterations was the main limitation. Although the diagnostic performance did not reach the current results of 3-T MRI, our study marks the way to implement clinical 7-T MRI of the shoulder.
Impact of transient temperature disturbance on the oxidative stress indices and glucose levels of juvenile Koi carps (Cyprinus carpio var koi)
Authors: Zutshi Bela , Singh Aradhana , Dasgupta Proteek 
Published: February 2020

Abstract
Background
The present study reports the changes in the redox state and glucose activity in gills and muscles of Koi carps, exposed to a short duration of acute thermal stress. The variation in levels of lipid peroxidation (LPO) and glutathione (GSH), catalase (CAT) and glutathione-S-transferase (GST) activity, in addition to glucose levels, were analysed after exposing the fishes to 15 °C (low), 25 °C (control) and 35 °C (high) for a duration of 3 and 6 h. The upper and lower temperatures regimes were decided by the Critical Thermal Limit (CTMAX and CTMIN).

Results
The CAT activity was high in both the tissues at 35 °C within 3 h, while LPO activity decreased throughout the study when compared with the control group indicating immoderate cellular disturbance and surplus oxidative stress. At 15 °C (3 h), tissues reported more glucose compared with the upper thermal slab. GSH increased in both the tissues at 15 °C compared with the control for 3 and 6 h. GST activity, however, flourished at 35 °C in muscles and gills for the 3-h regime.

Conclusion
The current study demonstrated disturbing impacts of temperature on the survivability of the Koi carps in a domesticated environment.