bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact assessment of check dam recharge sites in the pappiredipatti Watershed (South India) by using LULC and NDVI Data
Authors: Satheeshkumar S. , Venkateswaran S. 
Published: July 2020

Abstract
Abstract: Agriculture is one of the essential sector in because of the changing phenomenon of weather condition which is further complicated by the interaction of the vegetation with the environment. Scarcity of rainfall causes physiognomic changes can be identified by satellite images through the use of vegetation indices and landuse and land cover changes. The vegetation indices are sensitive to the rate of plant growth as well as to the amount of growth. They are sensitive to change in vegetation affected by moisture stress. Hence, scarcity can be monitored more systematically through remote sensing techniques than the ground based methods of collection of information. The capabilities of Geospatial techniques have been used to demarcate effective sites for monitoring functional characteristics of water conservation structures in the pappiredipatti watershed. In this study, land use/land covers have been used to delineate the existing recharge sites for water conservation measures. Increase of groundwater resource is proposed in the watershed by constructing runoff storage structures like as check dam, percolation tank and gabion structures. The site effective water conservation structures is determined by considering spatially varying parameters land use/land cover and natural difference vegetation index (NDVI) information of the watershed. Geospatial technique has been used to store, analyse, integrate spatial and attribute information pertaining to functional characteristics of land use and land cover within buffering distance in the area of interest of watershed. For detailed changes around recharge area assessment an attempt was made over the watershed. Crop growth area was assessed in and around under forest, barren land and dense vegetation area using temporal normalised difference vegetation index (NDVI) on 1985, 2005 and 2015. They have compared with vegetation area regions, and crop wise area growing were identified. Based on the result obtained from the study area on vegetation cover, buffered around recharge area impact was assessed by NDVI. Decrease in barren land on 2005 by identifying the NDVI threshold over predominantly sparse vegetation growing regions, crop wise area was identified. Further, the water body was estimated from NDVI data of 2005 and 2015 which have been validated for the vegetation assessment. The result of Landsat data use study indicated decrease in dense vegetation area that has leading to wide spread drought condition in the some part of the watershed.
The Global Use of Mobile Based Applications in Tuberculosis (TB) Care: A Systematic Review Protocol
Authors: Ncube Cynthia , Naidoo Saloshni , Mdul Takafira 
Published: July 2020

Abstract
Background: Tuberculosis remains one of the world’s deadliest communicable diseases despite being preventable and curable. The use of mobile phones has increased worldwide over the past decade and this has created opportunities to use mobile phones as intervention tools in health care including in promoting prevention, treatment and adherence monitoring and evaluation. However, the potential of information and communication technologies (ICTs) to fight TB remains largely untapped. Many countries are still researching further on how to use eHealth and mHealth effectively in the fight against TB. This systematic review protocol seeks to explore the mobile based applications that are being used in TB care globally and will provide crucial information to inform programming for the national TB programme, bringing the focus on interventions that really influence improving TB outcomes.Methods: A systematic review will be conducted through online searches using comprehensive Medical Subject Headings (MeSH) terms in various combinations. Information sources will include the Cochrane Central Register of Controlled Trials, Medline, Google Scholar and PubMed. The review will be done by 2 reviewers who will resolve discrepancies through consensus. Narrative data synthesis will be done.Discussion: Analysis of the selected studies will provide information on the use of the mobile applications in TB care globally. Conclusions will be based on the best available scientific evidence. The results will provide crucial information to inform programming for the national TB programme, bringing the focus on interventions that really influence improving TB outcomes. This will result in the effective use of resources by channelling them where there is the greatest impact in terms of reducing morbidity and mortality due to TB in Zimbabwe. Systematic review protocol registration: PROSPERO CRD42020154793
Engineering Properties Of Ceramsite Proppant And Its Application On Hydraulic Fracture For A Coalbed Methane Well
Authors: Zou Mingjun , Zhang Miao , Wu Jiaqi , Liu Yuanzheng 
Published: July 2020

Abstract
Ceramsite is a porous engineering material with some basic mineral constituents, and has advantages of low density, high sphericity and high flow conductivity. It should be a good attempt to be adopted in hydraulic fracture, but related researches are really weak. In this paper, laboratory experiments are conducted on ceramsite, coated ceramsite and other typical proppants, which indicates that the coated ceramsite is the best proppant. Then, a coalbed methane well located in the soft coal area in Qinshui basin of China is selected as the research object, numerical simulations and statistic analyses are both conducted to obtain the granularity proportion and parameter optimization by using coated ceramsite. Some findings are achieved. Numerical simulation indicates that the granularity proportion for coated ceramsites of 40/60, 16/40 and 12/20 mesh should choose 1:6:2, which can receive a biggest proppant concentration and strongest flow conductivity. Construction parameters are all optimized for a best fracture performance. Micro seismic monitoring indicates that the actual fracture performance matches well with the simulated result. Drainage performance comparisons reveal that coated ceramsite is suitable for soft coal areas, and can achieve good drainage performances.
Association Between Early Central Venous Pressure Measurement and Mortality in Patients With Sepsis: A Retrospective Study
Authors: Chen Han , Gong Shu-Rong , Shang Xiu-Ling , Yu Rong-Guo 
Published: July 2020

Abstract
Background: It remains controversial to abandon central venous pressure (CVP) in the monitoring of fluid resuscitation in sepsis patients. We hypothesized that early CVP measurement was associated with decreased mortality in critically ill patients with sepsis. Methods: Critically ill patients with sepsis were identified from the Medical Information Mart for Intensive Care (MIMIC)-III database. Patients were divided into two groups base on whether or not they had a CVP measurement within the first 6 hours of ICU stay. The primary endpoint was 28-day mortality. Patients were further divided into four subgroups base on the time when the first CVP measurement was obtained: within 3 hours, between 3 and 6 hours, between 6 and 12 hours, and not measured within 12 hours. Kaplan-Meier survival analysis and Cox regression model were used for univariate and multivariate analyses of survival, respectively.RESULTS: A total of 4733 sepsis patients were included. The 28-day mortality was significantly lower in the CVP measured group than in the control group (34.2 vs. 40.7, p < 0.001). A “U”-shaped relationship between initial CVP and mortality was identified. With patients without CVP measured within 12 hours serving as the reference subgroup, timely CVP measurement was associated with decreased 28-day mortality before and after adjusting for confounding variables.CONCLUSIONS: Early CVP measurement is associated with decreased 28-day mortality in patients with sepsis. CVP should be considered as a valuable and easily accessible safety parameter during (early) fluid resuscitation.
Sirt1 Protects Cartilage Against Degradation through FoxO1 Nucleo-cytoplasmic Shuttling and Positive Regulation of Autophagy
Authors: Xu Mao , Qian Zhuang , Zhang Ying , Gao Xin , Ma Zhengmin , Kang Xiaomin , Jin Xinxin , Li Huixia , Li Fang , Zhao Liting , Zhang Zhuanmin , Xu Min , Wu Shufang 
Published: July 2020

Abstract
Background: Sirt1 plays an important role in the pathophysiological process of osteoarthritis (OA) as we reported previously, however, the underlying mechanisms are still poorly addressed. Methods: The cartilage samples from OA patients’ knee joint were collected and detected histologically and immunohistochemistically. The effects of cartilage specific Sirt1 deletion on cartilage homeostasis were evaluated in destabilization of medial meniscus (DMM)-induced OA mice model (n=10). Finally, the underlying regulation of Sirt1 on cartilage was verified by coimmunoprecipitation (CoIP) and chromatin immunoprecipitation (ChIP) in vitro.Results: The expression levels of SIRT1, FoxO1 and autophagy decreased in OA cartilage. We further found that DMM-induced OA in cartilage specific Sirt1 deletion mice displayed an aggravated OA development, with increased chondrocytes hypertrophy and apoptosis while decreased autophagy activity. In vitro experiments indicated that FoxO1 regulated Sirt1 expression by nucleo-cytoplasmic shuttling through an auto-feedback loop leading to an increased autophagy level. Consistently, the activation of autophagy activity partly rescued OA-like changes in chondrocytes.Conclusions: Sirt1 protects cartilage against degradation through FoxO1 nucleo-cytoplasmic shuttling and positive regulation of autophagy, which all play a protective role in OA pathophysiological process, possibly partial adjustment by positive feedback.
Developing an Approach for Generating a Spatial Urban Health Equity Map and Validating via Volunteered Geographic Information
Authors: samani zeinab neisani , Karimi Mohammad , Alesheikh Aliasghar , Samany Najmeh neisani 
Published: July 2020

Abstract
Spatial urban health equity assessment is of vital importance, relating closely to quality of life standards and level of urban development. Generally, spatial health equity can be assessed according to spatial accessibility to health care and medical centers (HCMCs), green spaces, public transportation stations and main roads. The density and distribution of HCMCs are also important factors in spatial health equity assessment and air pollution level can also affect the health of citizens. This paper aims to model the spatial urban health equity map by aggregating all these criteria using reference data. Then, it compares the health equity map generated from reference data to one generated by volunteered geographic information (VGI) by citizens. The main contributions of this paper include i) aggregating spatial accessibility criteria, density and distribution of HCMCs and air pollution levels, based on the Mamdani fuzzy inference system (FIS), ii) comparing the spatial equity map with a health equity map achieved using VGI. Health equity status of citizens was categorized into five levels from ‘very appropriate’ to ‘very inappropriate’ and collected by citizens using a VGI website. The proposed method was implemented in District 6 of Tehran, Iran. Our findings showed for the resulting map with the reference data that almost 62% of the study area, was reported as ‘appropriate or ‘very appropriate’, 20% as ‘good’ and about 18% as ‘inappropriate’ or ‘very inappropriate’. The collected VGI from citizens achieved results with 72% compatibility. Furthermore, according to the precision, recall and F-score measures, most accuracy was attributed to the ‘appropriate’ level of spatial health equity and the least accuracy to the ‘very inappropriate’ level.
School-Based Cognitive Behavioral Intervention Program For Addressing Anxiety In 10- To 11-Year-Olds Using Short Classroom Activities: A Quasi-Experimental Study
Authors: Urao Yuko , Yoshida Michiko , Sato Yasunori , Shimizu Eiji 
Published: July 2020

Abstract
Background: Several school-based cognitive behavioral intervention programs have been developed to prevent and improve children’s anxiety disorders. Most programs require a duration of more than 10 hours for completion. We developed a cognitive behavioral program called “Journey of the Brave.” The study aimed to examine the effectiveness of the brief version of the program among 10- to 11-year-old children using 20-minute short classroom activities. Methods: A total of 90 children were divided into two groups (the intervention group, n=31 and the control group, n=59). The control group did not attend any program sessions and followed the regular school curriculum. We conducted fourteen weekly program sessions and assessed children at pre-intervention, post-intervention, and at 2-month follow-up (6 months after the start). The primary outcome measure was children’s anxiety symptoms, measured using the Spence Children’s Anxiety Scale (SCAS), and the secondary outcome measure was behavior problems, measured using the Strengths and Difficulties Questionnaire (SDQ).Results: A statistically significant reduction in the SCAS score in the intervention group was found at 2-month follow up compared with the control group. Significant reduction was also observed in the SDQ score. Conclusions: Our study suggested that this “Journey of the Brave” program, which requires only 5 hours using short classroom activities, demonstrated a similar effectiveness as the previous programs, which required over 10 hours.Trial registration: UMIN, UMIN000009021, Registered 10 March 2012, https://upload.umin.ac.jp/cgi-open-bin/icdr/ctr_view.cgi?recptno=R000010575
Modelling of the second (and subsequent) waves of the coronavirus epidemic. Spain and Germany as case studies
Authors: Castro Francisco de 
Published: July 2020

Abstract
The first wave of the coronavirus pandemic is waning in many countries. Some of them are starting to lift the confinement measures adopted to control it, but there is considerable uncertainty about if it is too soon and it may cause a second wave of the epidemic. To explore this issue, I fitted a SEIR model with time-dependent transmission and mortality rates to data from Spain and Germany as contrasting case studies. The model reached an excellent fit to the data. I then simulated the post-confinement epidemic under several scenarios. The model shows that (in the absence of a vaccine) a second wave is likely inevitable and will arrive soon, and that a strategy of adaptive confinement may be effective to control it. The model also shows that just a few days delay in starting the confinement may have caused and excess of thousands of deaths in Spain.
Study of digital lung three-dimensional imaging technology in early COPD
Authors: Tao Huimin , Shui Yuexiang , Fang Kai , Fang Yukun , Song Jia , Zhu Zhanying , Jiang Chunyan , Chen Qingyong 
Published: July 2020

Abstract
Background

COPD is characterized by progressive development of airflow limitation. Small airway functional and structural disease is considered pivotal in the pathology of early COPD. We used pulmonary function (PFT) and digital lung three-dimensional (3D) imaging technology to detect small airway functional and structural disease that applied for screening early COPD.
Methods

136 patients underwent PFT and CT at the 903th Hospital of People Liberation Army from January 2018 to January 2019, including 90 in the observation group and 46 in the control group. We tested the associations between digital lung 3D imaging technology parameters and PFT. Then, we detected small airway functional and structural disease by comparing digital lung 3D imaging technology parameters and PFT between the observation and control groups.
Results

There were correlations between digital lung 3D imaging technology parameters and PFT. Furthermore, compared with generation 5 bronchus, there were significant correlations between FEV1/FVC with generation 7 WT (r = -0.592; p < 0.01), and TDR (r = -0.608; p < 0.01). There were significant correlations between MEF50 with generation 7 WT (r = -0.607; p < 0.01), LA (r = 0.632; p < 0.01), and WA% (r = -0.643; p < 0.01). We found that we could evaluate the lung function change by the technology, and generation 7 bronchus were more effective in assessing small airway disease. There were significant differences between the observation and control groups in digital lung 3D imaging technology parameters and PFT (P < 0.05).
Conclusion

We found that the observation group had small airway functional and structural disease as compared with control group, which was diagnosed as early COPD. Our results showed that we could use PFT and digital lung 3D imaging technology to detect small airway functional and structural disease that applied for screening early COPD.
Flash Assisted Synthesis and Electrical Performance of MnO2-doped ZnO-Bi2O3-based Ceramics
Authors: Peng Pai , Chen Caohong , Niu Jingpeng , Shi Liyi , Liu Juan , Chen Guorong , Liu Zhiyuan , XU Dong 
Published: July 2020

Abstract
The authors have requested that this preprint be removed from Research Square.
Sustainability of the Exploitation of Campi Flegrei Geothermal Area Using a Zero-mass Extraction Device
Authors: Alimonti Claudio , Soldo Elena , Sepede Gennaro , Gómez-Lopera Salvador Ángel 
Published: July 2020

Abstract
In this paper, the use of a zero-mass extraction device has been simulated in the volcanic area of CampiFlegrei (Italy),one of the most promising geothermal districts of Italy.The sustainability of the heat extraction has been studied with a coupled model of the geothermal reservoir and the deep borehole heat exchanger. The reservoir model has been built using the SHEMAT software, the heat transfer in the deep borehole heat exchanger has been simulated using GEOPIPE, a pure conductive semi-analytical model. An iterative approach has been used to couple the two simulators. The work has demonstrated that the area of CampiFlegrei is a promising candidate to produce sustainable geothermal energy with a zero-mass extraction device. It is also demonstrated that the coupled model of reservoir and deep borehole heat exchanger is the best modelling approach when convective structures are present in the geothermal system, which can generate heat recovery effects.
Identification of Four Key Biomarkers and Small Molecule Drugs Innasopharyngeal Carcinoma by Weighted Gene Co-expression Network Analysis
Authors: Pan Xi , Liu Jian-Hao 
Published: July 2020

Abstract
Background

Nasopharyngeal carcinoma (NPC) is a heterogeneous carcinoma that the underlying molecular mechanisms involved in the tumor initiation, progression, and migration are largely unclear. The purpose of the present study was to identify key biomarkers and small-molecule drugs for NPC screening, diagnosis, and therapy via gene expression profile analysis.
Methods

Raw microarray data of NPC were retrieved from the Gene Expression Omnibus (GEO) database and analyzed to screen out the potential differentially expressed genes (DEGs). The key modules associated with histology grade and tumor stage was identified by using weighted correlation network analysis (WGCNA). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of genes in the key module were performed to identify potential mechanisms. Candidate hub genes were obtained, which based on the criteria of module membership (MM) and high connectivity. Then we used receiver operating characteristic (ROC) curve to evaluate the diagnostic value of hub genes. The Connectivity map database was further used to screen out small-molecule drugs of hub genes.
Results

A total of 430 DEGs were identified based on two GEO datasets. The green gene module was considered as key module for the tumor stage of NPC via WGCNA analysis. The results of functional enrichment analysis revealed that genes in the green module were enriched in regulation of cell cycle, p53 signaling pathway, cell part morphogenesis. Furthermore, four DEGs-related hub genes in the green module were considered as the final hub genes. Then ROC revealed that the final four hub genes presented with high areas under the curve, suggesting these hub genes may be diagnostic biomarkers for NPC. Meanwhile, we screened out several small-molecule drugs that have provided potentially therapeutic goals for NPC.
Conclusions

Our research identified four potential prognostic biomarkers and several candidate small-molecule drugs for NPC, which may contribute to the new insights for NPC therapy.
Detection of SARS-CoV-2 antibodies is insufficient for the diagnosis of active or prior COVID-19
Authors: Escribano Pilar , Alvarez-Uria Ana , Alonso Roberto , Catalán Pilar , Alcala Luis , Muñoz Patricia , Guinea Jesus 
Published: July 2020

Abstract
We assessed the performance of Abbott's SARS-CoV-2 IgG assay and the PanbioTM COVID-19 IgG/IgM rapid test device for the diagnosis of active and past/cured COVID-19. Three cohorts of patients were chosen. Cohort 1, patients (n=65) who attended the emergency department on March 30, 2020 with clinical suspicion of active COVID-19 (n=56 with proven/probable COVID-19). Cohort 2, hospital workers (n=92) who had either been (n=40) or not (n=52) diagnosed with proven/probable COVID-19 and were asymptomatic at the time of the sampling. Cohort 3, patients (n=38) cared at the hospital before the start of the COVID pandemic. Detection of serum antibodies was done using Abbott´s SARS-CoV-2 IgG assay and the PanbioTM COVID-19 IgG/IgM device. Both methods showed 98% agreement for IgG detection. No antibodies were detected in the 38 samples from hospitalized pre-COVID subjects. The diagnostic performance of IgGs detected by Abbott´s SARS-CoV-2 assay in Cohorts 1/2 was: sensitivity (60.7%/75%) and specificity (100%/84.6%). The diagnostic performance of IgM by PanbioTM COVID-19 in Cohorts 1/2 was: sensitivity (16%/17.5%) and specificity (100%/98.1%). We show that IgG detection alone is insufficient for the diagnosis of active or past COVID-19. IgM detection has a limited diagnostic value.
CircRNA circ-0110102 Function as Anti-oncogenic Gene in Hepatocellular Carcinoma through Modulating miR-580-5p/CCL2 Pathway
Authors: Wang Xinxing , Sheng Wei , Xu Tao , Xu Jiawen , Chen Juntao , Rong Zhonghou , Wang Zhiyi , Du Dongdong , Wang Yadong , Gao Ruyi , Zhang Zhenhai 
Published: July 2020

Abstract
Background

Circular RNAs (circRNAs) have been shown to have critical regulatory roles in tumor biology, whereas their contributions in hepatocellular carcinoma (HCC) still remains enigmatic. The purpose of this study was to investigate the molecular mechanisms involved in hsa_circ_0110102 in the occurrence and development of HCC.
Results

hsa_circ_0110102 was significantly down-regulated in HCC cell lines and tissues, low hsa_circ_0110102 expression levels were associated with poor prognosis. Knockdown hsa_circ_0110102 significantly inhibited cell proliferation, migration and invasion. In addition, the interaction between hsa_circ_0110102 and miR-580-5p was predicted and verified by luciferase assay and RNA pull-down, indicating that hsa_circ_0110102 function as sponge of miR-580-5p. Moreover, miR-580-5p which could directly bind to the 3’-UTR of CCL2 and induce its expression, then active the COX-2/PGE2 pathway in macrophage via FoxO1 in p38 MAPK dependent manner. Furthermore, the Δ256 mutant of FoxO1 showed no activation effect. These results concluded that hsa_circ_0110102 act as a sponge for miR-580-5p and decreased CCL2 secretion in HCC cells, then inhibits pro-inflammatory cytokine release from activated macrophage by regulating the COX-2/PGE2 pathway.
Conclusions

These results indicating that hsa_circ_0110102 serves as a potential prognostic predictor or therapeutic target for HCC.