bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipoadenoma of the Parathyroid Gland: Characterization of an Institutional Series Spanning 28 Years
Authors: Juhlin C. Christofer , Falhammar Henrik , Zedenius Jan , Nilsson Inga-Lena , Höög Anders 
Published: March 2020

AbstractParathyroid lipoadenomas (PLAs) are rare tumors, and case descriptions are limited, < 80 to date. As a consequence, scarce information regarding the etiology of these enigmatic lesions is available. We searched our departmental pathology database for PLAs diagnosed between 1992 and 2020, reexamined the histology of each case, and recorded clinical parameters from the patients’ medical charts. As the diagnostic criteria of this lesion vary over this time period, we defined PLA as an enlarged parathyroid gland with > 50% fat on histologic examination with preoperative evidence of primary hyperparathyroidism (PHPT). A total of 8 bona fide PLA cases and 2 equivocal PLAs (close to 50% fat) were included. As approximately 4000 conventional parathyroid adenomas were diagnosed at our department during the same time interval, the prevalence of PLA was 0.20%. PLA patients were predominately female (63%) and presented with classical PHPT-related symptoms. Majority of cases were successfully located preoperatively and had an average tumor weight of 445 mg. Histologically, all PLAs consisted of > 50% mature adipose tissue, except a single case with brown fat. Of note, PLA patients exhibited a body mass index in line with PHPT patients in general, but a relatively high, near-significant prevalence of arterial hypertension was observed when compared to tumors with less fat (P = 0.0584). Future studies on this finding might be warranted. To summarize, we present one of the largest institutional PLA case series to date, and conclude that PLAs are rare, sporadic tumors mirroring many clinical aspects of conventional adenomas—with a potential coupling to hypertension worthy of follow-up studies.
Insights into the applications of waste materials in the oil and gas industry: state of the art review, availability, cost analysis, and classification
Authors: Al-Hameedi Abo Taleb T. , Alkinani Husam H. , Albazzaz Hussien W. , Dunn-Norman Shari , Alkhamis Mohammed M. 
Published: March 2020

AbstractThis study investigates different types of waste materials and their applicability in the oil and gas industry as well as analyzing various applications of these waste materials in the petroleum industry. This study also explores the availability of these waste materials by performing a statistical analysis in a good number of countries worldwide. The statistical study was performed starting with a study on which countries generate waste the most overall, followed by examining multiple countries and investigating their top three most available waste. The results showed that the USA is the leading country in terms of municipal solid waste generation of 258 million metric tons, followed by China that generates around 220.4 million metric tons and then India that generates 168.4 million metric tons of municipal solid waste. The regions that generate the most food waste are North America and Oceania, providing the availability of food waste in those regions. Most of the palm tree wastes are available in the Middle East and some parts of the USA, while green waste can be found in the USA, China, and the UK. Sawdust wastes are mostly available in Europe and North America, while hay waste is abundant in the USA. Waste materials were also examined for various petroleum industry applications. Food wastes were found to be effective in drilling and completion fluids. Various food waste products were utilized to alter the drilling fluid properties such as potato peels and mandarin peels. Food wastes were also effective in altering the pH of the drilling fluids. Some plant-based wastes such as date trees were effective treatments used to stop lost circulation. Based on biodegradability and toxicity basis, waste materials were also classified into four main categories, which are eco-friendly, biodegradable, non-biodegradable, and toxic using color category classification. In summary, waste materials have the potential to be used in the petroleum industry, and they might as well be a good alternative for the future. As an example, the drilling fluid average cost approximately one-tenth of the total cost of the drilling operation, which is considered a tangible cost. By using waste materials as drilling fluid additives, the cost of the drilling fluid can be minimized. Further investigation and research should be carried out to get a better understanding of the importance of waste materials, and how they can be exploited for future applications in the oil and gas industry.
Single-cell transcriptomic analysis of adult mouse pituitary reveals sexual dimorphism and physiologic demand-induced cellular plasticity
Authors: Ho Yugong , Hu Peng , Peel Michael T. , Chen Sixing , Camara Pablo G. , Epstein Douglas J. , Wu Hao , Liebhaber Stephen A. 
Published: March 2020

AbstractThe anterior pituitary gland drives highly conserved physiologic processes in mammalian species. These hormonally controlled processes are central to somatic growth, pubertal transformation, fertility, lactation, and metabolism. Current cellular models of mammalian anteiror pituitary, largely built on candidate gene based immuno-histochemical and mRNA analyses, suggest that each of the seven hormones synthesized by the pituitary is produced by a specific and exclusive cell lineage. However, emerging evidence suggests more complex relationship between hormone specificity and cell plasticity. Here we have applied massively parallel single-cell RNA sequencing (scRNA-seq), in conjunction with complementary imaging-based single-cell analyses of mRNAs and proteins, to systematically map both cell-type diversity and functional state heterogeneity in adult male and female mouse pituitaries at single-cell resolution and in the context of major physiologic demands. These quantitative single-cell analyses reveal sex-specific cell-type composition under normal pituitary homeostasis, identify an array of cells associated with complex complements of hormone-enrichment, and undercover non-hormone producing interstitial and supporting cell-types. Interestingly, we also identified a Pou1f1-expressing cell population that is characterized by a unique multi-hormone gene expression profile. In response to two well-defined physiologic stresses, dynamic shifts in cellular diversity and transcriptome profiles were observed for major hormone producing and the putative multi-hormone cells. These studies reveal unanticipated cellular complexity and plasticity in adult pituitary, and provide a rich resource for further validating and expanding our molecular understanding of pituitary gene expression programs and hormone production.
Ranking and grouping social media requests for emergency services using serviceability model
Authors: Purohit Hemant , Castillo Carlos , Pandey Rahul 
Published: March 2020

AbstractSocial media has become an alternative communication mechanism for the public to reach out to emergency services during time-sensitive events. However, the information overload of social media experienced by these services, coupled with their limited human resources, challenges them to timely identify, prioritize, and organize critical requests for help. In this paper, we first present a formal model of serviceability calledSocial-EOC, which describes the elements of aserviceablemessage posted in social media expressing a request. Using the serviceability model, we then describe a system for the discovery and ranking of highly serviceable requests as well as for re-ranking requests by semantic grouping to reduce redundancy and facilitate the browsing of requests by responders. We validate the model for emergency services by experimenting with six crisis event datasets and ground truth provided by emergency professionals. Our experiments demonstrate that features based on both serviceability model and social connectedness improve the performance of discovering and ranking (nDCGgain up to 25%) service requests over different baselines. We also empirically validate the existence of redundancy and semantic coherence among the serviceable requests using our semantic grouping approach, which shows the significance and need for grouping similar requests to save the time of emergency services. Thus, an application of serviceability model could reduce cognitive load on emergency servicers in filtering, ranking, and organizing public requests on social media at scale.
Assessing Transparency, Accuracy, and Consistency of Relative Importance of Cow-Calf Profitability Drivers Using Neural Networks versus Regression
Authors: Tester Colson A. , Popp Michael P. , Dixon Bruce L. , Nalley Lanier L. 
Published: March 2020

AbstractUsing both multivariate regression and artificial neural networks, the relative impact of variables affecting cow-calf profitability was examined over two cattle cycles for spring- and fall-calving herds that varied in size by time period analyzed when using different fertility management affecting forage yields with and without weather uncertainty. Neural networks had greater predictive accuracy than regression but at the cost of lesser transparency and predictive consistency. Explaining profitability, price, and quantity of cattle sold were consistently and respectively ranked first and second using both approaches. Importance rankings for hay sold and fertilizer were low and less consistent across techniques employed.
Coordinated control of fuel flow rate and air flow rate of a supersonic heat-airflow simulated test system
Authors: Cai C. , Guo L. , Liu J. 
Published: March 2020

ABSTRACTThe gas temperature of the supersonic heat airflow simulated test system is mainly determined by the fuel and air flow rates which enter the system combustor. In order to realise a high-quality control of gas temperature, in addition to maintaining the optimum ratio of fuel and air flow rates, the dynamic characteristics of them in the combustion process are also required to be synchronised. Aiming at the coordinated control problem of fuel and air flow rates, the mathematical models of fuel and air supply subsystems are established, and the characteristics of the systems are analysed. According to the characteristics of the systems and the requirements of coordinated control, a fuzzy-PI cross-coupling coordinated control strategy based on neural sliding mode predictive control is proposed. On this basis, the proposed control algorithm is simulated and experimentally studied. The results show that the proposed control algorithm has good control performance. It cannot only realise the accurate control of fuel flow rate and air flow rate, but also realise the coordinated control of the two.
Dietary starch promotes hepatic lipogenesis in barramundi (Lates calcarifer)
Authors: Wade N. M. , Trenkner L. H. , Viegas I. , Tavares L. C. , Palma M. , Skiba-Cassy S. , Dias K. , Vachot C. , Araújo B. C. , Bourne N. , Blyth D. , Irvin S. , Glencross B. D. 
Published: March 2020

AbstractBarramundi (Lates calcarifer) are a highly valued aquaculture species, and, as obligate carnivores, they have a demonstrated preference for dietary protein over lipid or starch to fuel energetic growth demands. In order to investigate how carnivorous fish regulate nutritional cues, we examined the metabolic effects of feeding two isoenergetic diets that contained different proportions of digestible protein or starch energy. Fish fed a high proportion of dietary starch energy had a higher proportion of liver SFA, but showed no change in plasma glucose levels, and few changes in the expression of genes regulating key hepatic metabolic pathways. Decreased activation of the mammalian target of rapamycin growth signalling cascade was consistent with decreased growth performance values. The fractional synthetic rate (lipogenesis), measured by TAG 2H-enrichment using 2H NMR, was significantly higher in barramundi fed with the starch diet compared with the protein diet (0·6 (se 0·1) v. 0·4 (se 0·1) % per d, respectively). Hepatic TAG-bound glycerol synthetic rates were much higher than other closely related fish such as sea bass, but were not significantly different (starch, 2·8 (se 0·3) v. protein, 3·4 (se 0·3) % per d), highlighting the role of glycerol as a metabolic intermediary and high TAG-FA cycling in barramundi. Overall, dietary starch significantly increased hepatic TAG through increased lipogenesis. Compared with other fish, barramundi possess a unique mechanism to metabolise dietary carbohydrates and this knowledge may define ways to improve performance of advanced formulated feeds.
Morphological and genetic description ofMoniliformis necromysisp. n. (Archiacanthocephala) from the wild rodentNecromys lasiurus(Cricetidae: Sigmondontinae) in Brazil
Authors: Gomes A.P.N. , Costa N.A. , Gentile R. , Vilela R.V. , Maldonado A. 
Published: March 2020

AbstractA new species ofMoniliformisTravassos, 1915 (Acanthocephala: Moniliformidae) is described from the hairy-tailed bolo mouse,Necromys lasiurusLund, 1840 (Cricetidae: Sigmondontinae), captured in the Brazilian Cerrado, in Uberlândia, state of Minas Gerais, Brazil. The specimens were studied by light and scanning electron microscopy. Molecular phylogenies were inferred from partial nuclear large subunit ribosomal RNA gene sequences and partial mitochondrial cytochromecoxidase subunit I gene. The new species is distinguished from other moniliformid species by the number of rows and number of hooks per row, size of the proboscis, size of the eggs, host species and geographical distribution. Molecular phylogenies and genetic distances analyses demonstrated thatMoniliformis necromysisp. n. forms a well-supported monophyletic group with sequences of other species ofMoniliformisand is distinguished from them, which agrees with the morphological characteristics, allocating the new species to this genus and to the family Moniliformidae Van Cleave, 1924. This is the first moniliformid acanthocephalan described from a wild rodent in Brazil.
Wulfstan the Forger: the ‘Laws of Edward and Guthrum’
Authors: Schwartz Nicholas P. 
Published: March 2020

AbstractDespite the recent increase in attention given to Archbishop Wulfstan and his writings, the so-called ‘Laws of Edward and Guthrum’ – a lawcode forged by the archbishop in the opening years of the eleventh century – has received little analysis since Dorothy Whitelock’s 1941 study established the churchman as its true author. My article seeks to fill this gap firstly by expanding on Whitelock’s article. I show that many more of the text’s clauses function as antecedents to Wulfstan’s later legislation than those she identified in her important article. Second, I argue that §10 of the code, a clause not repeated in the archbishop’s later legislation, surely still held legal authority given Wulfstan’s prescriptions for non-lethal punishment in some cases. Finally, I posit that Wulfstan’s attribution of the code to Alfred, seen in its opening, reflects the archbishop’s value of him as a king worth emulating.
The determinants of maternal homocysteine in pregnancy: findings from the Ottawa and Kingston Birth Cohort
Authors: Chaudhry Shazia H , Taljaard Monica , MacFarlane Amanda J , Gaudet Laura M , Smith Graeme N , Rodger Marc , Rennicks White Ruth , Walker Mark C , Wen Shi Wu 
Published: March 2020

AbstractObjective:Observational studies have linked elevated homocysteine to vascular conditions. Folate intake has been associated with lower homocysteine concentration, although randomised controlled trials of folic acid supplementation to decrease the incidence of vascular conditions have been inconclusive. We investigated determinants of maternal homocysteine during pregnancy, particularly in a folic acid-fortified population.Design:Data were from the Ottawa and Kingston Birth Cohort of 8085 participants. We used multivariable regression analyses to identify factors associated with maternal homocysteine, adjusted for gestational age at bloodwork. Continuous factors were modelled using restricted cubic splines. A subgroup analysis examined the modifying effect of MTHFR 677C>T genotype on folate, in determining homocysteine concentration.Setting:Participants were recruited in Ottawa and Kingston, Canada, from 2002 to 2009.Participants:Women were recruited when presenting for prenatal care in the early second trimester.Results:In 7587 participants, factors significantly associated with higher homocysteine concentration were nulliparous, smoking and chronic hypertension, while factors significantly associated with lower homocysteine concentration were non-Caucasian race, history of a placenta-mediated complication and folic acid supplementation. Maternal age and BMI demonstrated U-shaped associations. Folic acid supplementation of >1 mg/d during pregnancy did not substantially increase folate concentration. In the subgroup analysis, MTHFR 677C>T modified the effect of folate status on homocysteine concentration.Conclusions:We identified determinants of maternal homocysteine relevant to the lowering of homocysteine in the post-folic acid fortification era, characterised by folate-replete populations. A focus on periconceptional folic acid supplementation and improving health status may form an effective approach to lower homocysteine.
Revitalizing cultivation and strengthening the seed systems of fonio and Bambara groundnut in Mali through a community biodiversity management approach
Authors: Sidibé Amadou , Meldrum Gennifer , Coulibaly Harouna , Padulosi Stefano , Traore Issa , Diawara Gaoussou , Sangaré Adja Rokiatou , Mbosso Charlie 
Published: March 2020

AbstractFonio (Digitaria exilis(Kippist) Stapf) and Bambara groundnut (Vigna subterranea(L.)Verdc.) are native crops grown at a small scale in Mali that have potential to support agricultural productivity under climate change. A community biodiversity management approach was explored in this study as a means to reinforce the cultivation of these crops by increasing farmers' access to intraspecific diversity and developing capacities of community institutions for their management. The research involved six communities in Ségou and Sikasso regions. Multiple varieties of fonio (10–12) and Bambara groundnut (8–12) were established in diversity fields in each site over 2 years where farmers engaged in experiential learning over the crop cycle. Significant adoption of fonio and Bambara groundnut was detected in several study sites. The precise drivers of adoption cannot be definitively determined but likely include increased seed access and awareness gained through the diversity field fora, seed fairs and community seed banks. No significant yield advantage was detected for any of the varieties in the diversity fields, which showed variable performance by site and year. The number of varieties registered and managed by community seed banks in each site increased from 1–5 varieties of each crop to 11–12 varieties following the interventions. The number of Bambara groundnut varieties cultivated in farmers' fields also increased, while there was evidence of a slight decline in fonio diversity in some communities. The results of this study can inform efforts to strengthen seed systems and cultivation of neglected and underutilized species in Africa.
Design and characterization of a dual-band miniaturized circular antenna for deep in body biomedical wireless applications
Authors: Ding Shuoliang , Koulouridis Stavros , Pichon Lionel 
Published: March 2020

AbstractIn this paper, a novel miniaturized implantable circular antenna is presented. It supports both wireless information communication and wireless energy transmission at the Medical Device Radiocommunication band (MedRadio 402–405 MHz) and the industrial, scientific, and medical bands (ISM 902.8–928 MHz). The antenna is circular to avoid sharp edges while miniaturization is achieved by adding two circular slots to the patch. The main scenario includes embedding into the muscle layer of a cylindrical three-layer model of a human arm for which several parameters are analyzed (resonance, radiation pattern, and specific absorption rate). Power transmission efficiency and interaction distance limits to ensure connections are also evaluated. Finally, the design is validated by an experimental measurement in an anechoic chamber, and some new improvements are proposed.
Administration of ursolic acid to new-born pups prevents dietary fructose-induced non-alcoholic fatty liver disease in Sprague Dawley rats
Authors: Mukonowenzou Nyasha C. , Dangarembizi Rachael , Chivandi Eliton , Nkomozepi Pilani , Erlwanger Kennedy H. 
Published: March 2020

AbstractOverconsumption of fructose time dependently induces the development of non-alcoholic fatty liver disease (NAFLD). We investigated whether ursolic acid (UA) intake by new-born rats would protect against fructose-induced NAFLD. One hundred and seven male and female Sprague Dawley rat pups were randomly grouped and gavaged (10 ml/kg body weight) with either 0.5% dimethylsulphoxide (vehicle control), 0.05% UA, 50% fructose mixed with UA (0.05%) or 50% fructose alone, from postnatal day 6 (P6) to P20. Post-weaning (P21–P69), the rats received normal rat chow (NRC) and water to drink. On P70, the rats in each group were continued on water or 20% fructose to drink, as a secondary high fructose diet during adulthood. After 8 weeks, body mass, food and fluid intake, circulating metabolites, visceral adiposity, surrogate markers of liver function and indices of NAFLD were determined. Food intake was reduced as a result of fructose feeding in both male and female rats (p < 0.0001). Fructose consumption in adulthood significantly increased fluid intake and visceral adiposity in female rats (p < 0.05) and had no apparent effects in male rats (p > 0.05). In both sexes of rats, fructose had no significant (p > 0.05) effects on body mass, circulating metabolites, total calorie intake and surrogate markers of hepatic function. Fructose consumption in both early life and adulthood in female rats promoted hepatic lipid accumulation (p < 0.001), hypertrophy, microvesicular and macrovesicular steatosis (p < 0.05). Early-life UA intake significantly (p < 0.001) reduced fructose-induced hepatic lipid accumulation in both male and female rats. Administration of UA during periods of developmental plasticity shows prophylactic potential against dietary fructose-induced NAFLD.
A Time‐Varying 3‐D Displacement Model of the ~5.9‐Year Westward Motion and its Applications for the Global Navigation Satellite System Positions and Velocities
Authors: Ding Hao , Xu XinYu , Pan YuanJin , Jiang WeiPing , Van Dam Tonie 
Published: March 2020

AbstractTo advance geodynamics and geophysical research, high precision Global Navigation Satellite System (GNSS) observations of velocity and position are needed. In this study, we construct a 3‐D model of a ~5.9‐year periodic signal for the Earth surface displacements. This model is mainly based on the determined time sequences and the Y22 spatial pattern of this ~5.9‐year periodic signal from the global Global Positioning System (GPS) observations. Based on the constructed model, we calculate synthetic temporal 3‐D displacements on the Earth surface and the velocity changes, and we compare them to observed GPS displacements. Our results reveal that the ~5.9‐year signal contributes to surface displacements and velocity fields. Maximum displacements for the N, E, and U components can reach up to 0.28, 0.55, and 1.69 mm, respectively; maximum velocity effects can up to 1.69 mm/year for the U component (depending on record length). For those studies which need millimeter or even submillimeter accuracy (e.g., tectonic deformations, glacial isostatic adjustment, and deformations caused by core motions), these effects cannot be simply ignored. Our results also confirm that the model we present here can heavily reduce the ~5.9‐year signal in the original GPS time series. We suggest that our model should be used to pretreatment the GPS data at the observation level, which could improve signals used for geophysical or geodynamic interpretations.