bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical observation of short-term on primary pars plana vitrectomy without perfluorocarbon fluids under the wide-angle observation system in treatment rhegmatogenous retinal detachment with PVR ≦C2
Authors: Wang Qichang , Cheng Bei , Peng Xin , Zhang Shanshan , Su Yueyan , Zeng Jiaojiao 
Published: July 2020

Abstract
Background: To observe the short-term efficacy of vitrectomy for wide-angle observation system without perfluorocarbon liquid (PFCL )in the treatment of rhegmatogenous retinal detachment(RRD) with Proliferative vitreous retinopathy (PVR ) ≦C2.Methods: Retrospective analysis of the case data of patients with rhegmatogenous retinal detachment who did not use or use perfluorocarbon liquid during vitrectomy, including age, sex, course of disease, PVR classification, preoperative and stepwise best corrected positive vision , Perfluorocarbon liquid in the perfluorocarbon liquid group, the reposition state of the retina, the difference in visual acuity recovery and retina reset rate within and between groups.Results: There was no statistically significant difference in baseline data (age, sex, course of disease, PVR grade) between the non-perfluorocarbon liquid group and the perfluorocarbon liquid group (P> 0.05). The rate of initial reset at the time of discharge from the non-perfluorocarbon liquid group was 92.9%. The retinal reposition rate at 6 months after surgery was 100%. The rate of initial reduction at discharge was 93.5% in the group using perfluorocarbon liquid, and the final retinal reduction rate at 6 months after surgery was 100%. There was no statistically significant difference in logMAR BCVA of postoperative follow-up time between the two groups (P> 0.05). Without the use of perfluorocarbon liquid, there was no postoperative perfluorocarbon liquid residue, and the residual rate of perfluorocarbon liquid in the perfluorocarbon liquid group was 14.5%.Conclusion: Vitrectomy without the use of perfluorocarbon fluids under the wide-angle observation system is the first choice to treat rhegmatogenous retinal detachment with PVR≤C2.
Identifying conflict of interest disclosure in systematic reviews of surgical interventions and devices: a cross-sectional survey
Authors: Yu Jiajie , Su Guanyue , Hirst Allison , Yang Zengyue , Zhang You , Li Youping 
Published: July 2020

Abstract
Background
Conflict of interest (COI) is an important source of bias in research and disclosure is the most frequent strategy to manage COI. Considering the importance of systematic reviews (SRs) and the prevalence of COI is varying among different research fields and the, we conducted a survey to identify the range of conflict of interest in SRs assessing surgical intervention and devices, and explored the association between COI disclosure and conclusion.
Methods
We retrieved SRs of surgical interventions and devices published in 2017 via PubMed. Information regarding general characteristics, funding source and COI disclosure were extracted. We conducted a descriptive analyses of study characteristics of included systematic reviews. The difference between groups in the authors’ conclusions were compared using the Chi-square test. Results were expressed as odds ratio and its 95% confidence interval.
Results
155 SRs were finally identified in 2017, more than half of SRs (58.7%) reported their funding source and 94.2% reported authors’ COI disclosure. Among 146 SRs that stated COI disclosures, only 35 (22.6%) SRs declared at least one author had a COI. More than 40 terms were used to describe COI. Cochrane SRs were more likely to provide a detail description of COI comparing with those in non-CSR (48.0% versus 25.4%, P = 0,023). No association between positive conclusion and COI disclosure was found (P = 0.484, OR = 0.43, 95%CI: 0.08, 2.16). In the subgroup analyses, SRs stating no COI disclosure were more likely to report positive conclusion than those stating at least one type of COI, but the difference is not significantly different (P = 0.406, OR = 1.38, 95%CI: 0.64, 2.98)
Conclusion
A high rate of COI disclosure without any detailed information. Although little impact of COI disclosure on author’ conclusions in SRs was found for limited sample, clear description of all potential COI is the best way to enhance the credibility of published scholarship and unbiased evidence-informed decision.
ApoD and ApoA-IV, novel proteomic components in HDL of diabetic kidney disease without dialysis
Authors: Santana Monique FM , Lira Aécio LA , Pinto Raphael , Minanni Carlos A , Silva Amanda RM , Sawada Maria IBAC , Nakandakare Edna R , Correa-Giannella Maria LC , Queiroz Marcia S , Ronsein Graziella E , Passarelli Marisa 
Published: July 2020

Abstract
Background and aims: Diabetic kidney disease (DKD) is associated with lipid derangements worsening kidney function and enhancing cardiovascular (CVD) risk. The management of dyslipidemia, hypertension and other traditional risk factors does not completely prevent CVD complications bringing up the participation of untraditional risk factors such as advanced glycation end products (AGEs), carbamoylation and changes in HDL proteome and functionality. We analyzed HDL composition, proteome, chemical modification and functionality in non-dialytic DKD subjects categorized according to estimated glomerular filtration rate (eGFR) and urinary albumin excretion rate (AER). Methods: DKD individuals were divided in eGFR>60 mL/min/1.73 m2 plus AER stages A1 and A2 (n=10) and eGFR<60 plus A3 (n=25) and matched by age with control subjects (eGFR>60; n=8). Results: Targeted proteomic analyses quantified 28 proteins associated with HDL in all groups, although only 2 were more expressed in eGFR<60+A3 group in comparison to controls: apolipoprotein D (apoD) and apoA-IV. HDL from eGFR<60+A3 presented higher levels of total AGEs (20%), pentosidine (6.3%) and carbamoylation (4.2 x) and a reduced ability in removing 14C-cholesterol from macrophages (33%) in comparison to controls. The antioxidant role of HDL (lag time for LDL oxidation) was similar among groups but HDL from eGFR<60+A3 presented a higher ability in inhibiting the secretion of IL6 and TNF alpha (95%) in LPS-elicited macrophages in comparison to control group. Conclusion: The increment in ApoD and ApoA-IV seems to counteract the HDL chemical modification by AGE and carbamoylation that contributes for HDL loss of function in well-established DKD.
Worries and Concerns of Healthcare Workers About COVID-19 Pandemic in a Tertiary Care Setting With a Previous MERS-COV Outbreak Experience
Authors: Abolfotouh Mostafa A. , Almutairi Adel F. , BaniMustafa Ala'a A. , Hussein Mohamed A. 
Published: July 2020

Abstract
BackgroundCovid-19 was declared by the WHO as a worldwide pandemic on 11 March 2020. As of 11th June, 2020, Saudi Arabia had 112,288 infected cases, with 77,954 recoveries and 819 deaths. Healthcare workers (HCWs) are at higher risk of acquiring and transmitting this virus, so the concerns of HCWs in Saudi Arabia regarding Covid-19 were evaluated in comparison with their concerns about the previous MERS-CoV outbreak.Methods.HCWs at three tertiary hospitals in Saudi Arabia were surveyed via email, by a concern scale about Covid-19 pandemic during 15–30 April, 2020. Concerns of disease severity, governmental efforts to contain it and disease outcomes were assessed using 32 concern statements in five distinct domains. Multiple regression analyses were used to identify predictors of high concern scores.Results.A total of 844 HCW responded to the survey. Their average age was 40.4 ± 9.5 years, 40.3% were nurses, 58.2% had direct patient contact, and 77.3% were living with family members and/or others. The majority of participants (72.1%) had an overall concern score of 55 or less out of a maximum score of 96 points. Three-fourth of respondents felt at risk of contracting Covid-19 infection at work, 69.1% felt threatened if a colleague contracted Covid-19, 69.9% felt obliged to care for patients infected with Covid-19 while 27.7% did not feel safe at work using the standard precautions. Nearly all HCWs believed that the government should isolate patients with Covid-19 in specialized hospitals (92.9%), agreed with travel restriction to/from areas affected by Covid-19 (94.7%) and felt safe government implemented curfew and movement restriction periods (93.6%). Predictors of high concern scores were; HCWs of Saudi nationality (p < 0.001), younger age (p = 0.003), undergraduate education (p = 0.044), living with others (p = 0.003) working in the western region (p = 0.003) and direct contact with patients (p = 0.018).Conclusions.The current study highlights the high concern among healthcare workers about Covid-19 and identifies the predictors of those with highest concern levels. To minimize the potential negative impact of those concerns on the performance of HCWs during pandemics, measures are necessary to enhance their protection and to minimize the psychological effect of the perceived risk of infection.
Young Women’s Preferences for Different Types of Sexual Relationships. Implications for Gender-Based Violence Prevention Programs and Policies.
Authors: Ruiz-Eugenio Laura , Racionero-Plaza Sandra , Duque-Sanchez Elena , Puigvert-Mallart Lidia 
Published: July 2020

Abstract
Background
Gender-based violence among young women is a growing problem worldwide. The consequences of this victimization have been well reported in the scientific literature, among which negative health outcomes stand out. The factors influencing this problem are many; one highlighted by research is socialization into a dominant coercive discourse that associates sexual-affective attraction to males with violent attitudes and behaviors, while in turn, such discourse empties males with egalitarian behaviors from sexual attractiveness. This coercive discourse may be shaping the sexual preferences of female youth. The current paper explores young women’s preferences for different types of sexual relationships and, more particularly, for what type of sexual affective relationships they coercively preferred men with violent attitudes and behavior.
Methods
A quantitative, mixed-design vignette study was conducted with 191 college females in Spain. We focused the analysis only on responses about vignettes including narratives of men with violent attitudes and behaviors. In addition, we examined whether participants would report higher coerced preferences for violent men when asked about the coerced preferences of their female friends than when asked about their own preferences.
Results
Only 28.95% of participants responded that their female friends would prefer a young man with violent behavior for a stable relationship, meanwhile 58.42% would do it for hooking up. When reporting about themselves, the difference was greater: 28.42% would prefer a young man with violent behavior for hooking up and just 5.78% for a stable relationship.
Conclusions
The dominant coercive discourse that links attractiveness to people with violent attitudes and behaviors may be explaining the results obtained in this study. The findings can help eliminate the stereotype largely adopted by some intervention and prevention programs which assume that gender-based violence occurs mainly in stable relationships, considering that falling in love is the reason that lead women to suffer from violence. Our results can also support health professionals and others serving young women to enhance their identification of gender violence victimization, as well as our findings point to the need to include the evidence of gender violence in sporadic relationships in prevention programs and campaigns addressed to young women.
Research on the Dynamic Compensation Method of the Shock Wave's Evaluation Pressure Sensor
Authors: Wang Wei 
Published: July 2020

Abstract
Due to the steep and changing fast rising edge of explosion shock wave signal, it asks for good dynamic characteristic of sensor and test system. As far as the development of the sensor level, they are difficult to achieve dynamic characteristic requirement of approximate distortionless transmission, so cause a large dynamic error in the actual test. This paper, aiming at providing theoretical support for technology guarantee and service of the shock wave testing system of national shooting range, conducts a research on the method of dynamic characteristic compensation of pressure sensor facing the power evaluation of the blast shock wave. The research proposes and studies the filter design method of dynamic compensation of pressure sensor based on PFQPSO (the progressive function quantum-behaved particle swarm optimization) algorithm, which belongs to inverse modeling. The dynamic compensation can be realized without knowing the model of sensor, so the extra error caused by dynamic modeling of sensors can be avoided. using 8510 series sensor can be used with lower natural frequency and lower measurement range from Endevco Company, this research has had experiment and modeling on the dynamic characteristics of shock tubes as well as design of dynamic compensation filter. Based on the analysis and confirmation, this study illustrates the possibility and effectiveness of this method.
Allografts with titanium cage in the treatment of tuberculous spondylitis: at least 3-year follow-up study
Authors: Wang Yanjun , Zhang Hong 
Published: July 2020

Abstract
Background Anterior radical debridement and spinal fusion with instrumentation have been advocated in treating the spinal tuberculosis patients. But there are few long-term studies on the efficacy of fresh-frozen allografts with titanium cage in reconstruction of the anterior spinal column after debridement and decompression for tuberculosis. The purpose of this study was to evaluate the efficacy of anterior allografts with titanium cage which were stabilized with anterior or posterior instrumentation at least 3-year follow-up study.Methods A retrospective analysis of 133 patients were treated between January 2002 and December 2012. There were 71 men and 62 women. Those patients were evaluated according to clinical and radiographical record for a minimum of 3 year, including deformity correction, pain and neurologic status. The kyphosis deformity was measured on lateral radiographs according the angle between the superior endplate of the first upper uninvolved vertebra and the first lower uninvolved vertebra. In the lumbosacral region, the kyphosis angle was measured by two lines along the posterior border of the first normal vertebra above the level of the lesion and posterior margin of sacrum on lateral radiographs. Clinical evaluation of back pain was evaluated and documented according to VAS pain score. Patients with neural deficits were graded according to the ASIA scale.Results The preoperative kyphosis deformity improved in all patients postoperatively from a mean of 20.8° (range, 12°-35°) to 3.9° (range, 2°-7°), with the average deformity correction of 16.1° (t = 38.59, p < 0.0001). The earliest radiologic evidence of allograft incorporation was identified between 18 and 24 months after surgery, and bony fusion was seen in all patients at final follow-up. We put forward our criteria to classify allograft incorporation at the last follow-up. Grade 1 49 patients; Grade 2 73 patients; Grade 3 11 patients; Grade 4 no patient. The average VAS pain score was 7.7 (range, 6–9) preoperatively, and decreased to 1.4 (range, 1–3) 3 months after surgery (t = 97.88, p < 0.0001 vs. initial). Of the 44 patients who developed neural deficits before their operations, 41 patients improved according to the ASIA AIS. 3 patients did not have substantial improvement and remained Grade AIS B.Conclusions Radical debridement followed by allograft with titanium cage in reconstruction of the anterior spinal column offers very satisfactory results in patients with tuberculous spondylitis. It provides immediate stability, offers lasting kyphosis correction, bypasses the donor site morbidity and difficulties involved in obtaining structural autograft.
Comparison of the effect of Chamomile and Mefenamic Acid on primary dysmenorrhea, associated symptoms and menstrual bleeding – A randomized clinical trial study
Authors: Shabani Fatemeh , Vakilian Katayon , Narenji Fereshteh , Bozorgi Mahbubeh , Bioos Soodabeh , Nejatbakhsh Fatemeh 
Published: July 2020

Abstract
Background

Dysmenorrhea is one of the most common pelvic pains in women, impairing their quality of life.This study investigated the effects of chamomile sachet and mefenamic acid on primary dysmenorrhea, associated symptoms and bleeding.
Methods

In this randomized clinical trial, 200 female students with primary dysmenorrhea from Arak universities were randomly assigned to two groups. The group (A) received mefenamic acid (250 mg) and group (B) received chamomile (5000 mg) plus one teaspoonful of honey )as a flavoring( for two days before up to the first three days of menstruation, three times a day in two consecutive cycles. Pain severity, associated symptoms and bleeding were assessed using visual analog scale, Andersch-Milsom Verbal Scale and Higham chart, respectively. Data were analyzed by descriptive and inferential statistical tests by SPSS 21.
Results

Severe pain during two months after intervention was in 6 (6.3%) of group (B) and 6 (6.3%) in group (A) (p = 0.351, p = 0.332). Mean severity of associated symptoms two months after the treatment was( 4.93 ± 3.54) in group (B) and (5.62 ± 3.54 ) in group (A), indicating further reduction in group (B) but not significant (p = 0.278). Mean of bleeding was (88.71 ± 66.4 vs. 70.54 ± 53. 34) in group (B) and (A) respectively, in two months later. therefore decrease in the two groups but was not significant between groups(p = 0.567).
Conclusions

It seems chamomile sachet can reduce the severity of pain and bleeding similar to mefenamic acid and even further mitigate the symptoms associated with dysmenorrhea.
Trial registration:

This study was performed with the proposal approval code of 2611, ethics code of (ARAKMU.REC.1395.164) at Arak University of medical sciences and code of IRCT 2016100825031N5 on 2016.11.08.
Metabonomics Study on the Effect of Traditional Chinese Medicines Feed Addition on Growth Performance and Serum Metabolic Profile of Juvenile Chinese Softshell Turtle (Pelodiscus Sinensis Wiegmann) using UPLC–Triple /TOF–MS Analysis
Authors: Xiao Mingsong , Bao Fangyin , Wang Yuliang , Liu Huabin , He Jixiang 
Published: July 2020

Abstract
The authors have withdrawn this preprint due to author disagreement.
Female Developmental Environment Delays Development of Male Honeybee (Apis Mellifera)
Authors: Liu Yi Bo , Yi Yao , Abdelmawla Amal , Zeng Zhi Jiang , He Xu Jiang 
Published: July 2020

Abstract
Background
Nutrition and cell size play an important role in the determination of caste differentiation in queen-worker of honeybee (Apis mellifera), whereas the haploid genome dominates the differentiation of drones. However, the effects of female developmental environment on the development of males remain unclear. In this study, young drone larvae were transferred into worker cells (WCs) or remained in drone cells (DCs) to rear drones. The parts of drone larvae were also grafted into queen cells (QCs) for 48 h and then transplanted into drone cells until emerging. Morphological indexes and reproductive organs of these three types of newly emerged drones were measured. Newly emerged drones and 3 d drone larvae from WCs, DCs and QCs were sequenced by RNA sequencing (RNA-Seq).
Results
Morphological results showed that newly emerged DC drones had bigger body sizes and more well-developed reproductive tissues than WC and QC drones, whereas the reproductive tissues of QC drones were relatively better than those of WC drones. Gene expression results showed a more clear difference among three groups. At the larval stage, there were 889, 1761 and 1927 significantly differentially expressed genes (DEGs) in WC/DC, QC/DC and WC/QC comparisons, respectively. The number of DEGs decreased in adult drones of these three comparisons [678 (WC/DC), 338 (QC/DC) and 518 (WC/QC)]. A high number of DEGs were involved in sex regulation, growth, olfaction, vision, mammalian target of rapamycin (mTOR), Wnt signaling pathways, etc. Weighted gene co-expression network analysis (WCGNA) showed that WC and DC larvae were closer than QC larvae, whereas QC and WC drones were closer than DC drones. These results revealed that DC drones had better development in the body and reproductive system than QC and WC drones.
Conclusion
This study demonstrated that the developmental environment of honeybee females including the larval diet and cell size delayed male development. Naturally, honeybee colony ovigerous workers in queen-less colonies or non-mated queens produce a large number of dysplasia drones which are not well-developed. Therefore, this study serves as a model for understanding the regulation of sexual differentiation in social insects by environmental factors.
Performance Management Function and Retention of Health Workers: A Mixed-Methods Study from Public District Hospitals in Rwanda
Authors: Ndikumana Celestin , Kwonyike Joshua , Tubey Ruth , Niragire François , Kambanda Safari 
Published: July 2020

Abstract
Background: Human resources for health are the major component of the health system. Hence health workers are key to better health care service delivery. However, retention of the health workers is one of the major challenges facing the health system in Rwanda, especially in public district hospitals that serve as a major unit of health care service delivery in the country. The study investigated the effect of implementation of performance management function on the retention of professional health workers in public hospitals in Rwanda.Methods: The study used convergent parallel mixed-methods design. A sample of 252 health workers was selected from a population of 402 doctors, nurses, midwives, pharmacists and dentists. Data collection was conducted by use of questionnaire, interviews and focus group discussions. Quantitative data analysis used descriptive statistics and logistic regression models. Qualitative data were analysed by doing thematic analysis, by identifying themes in textual data. Triangulation used qualitative data to expound quantitative data. Data analysis was supported by Stata 13.1 and NVivo 10 softwares.Results: The findings from both quantitative and qualitative data show that health workers generally feel that there exists performance management function in hospitals with slight differences across its major indicators. The study also shows that while performance management planning and evaluation were found to be associated with health workers’ intentions to stay, there was no significant association between performance rewarding and intentions to stay. In fact, health workers who felt that performance management planning was at average and high level were 14.2 and 60 times more likely to stay (OR=14.2; P=0.000 and OR=60.13; P=0.000, respectively). Similarly, while health workers who rated performance evaluation exercise as average were more likely to stay (OR=1.472; P=0.029), perceiving a high level of implementation of performance evaluation in the hospital was associated with 2.215 odds of staying (OR=2.215; P=0.048). Conclusion: Generally, there are divergent levels perceptions on performance management indicators across respondents, and high levels of intentions to leave are noticed among health workers. Although performance planning and rewarding are associated with health workers’ intentions to stay, the existing level of implementation performance management function may have adversely affect retention of health workers.