bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plant breeding capacity in U.S. public institutions
Authors: Coe Michael T. , Evans Katherine M. , Gasic Ksenija , Main Dorrie 
Published: May 2020

AbstractSeveral studies in recent decades have warned that plant breeding capacity in U.S. institutions may be declining, placing our food system at risk. To further understand the status, trajectory, and needs of these programs, a national survey was conducted in 2018. Public‐sector plant breeding programs (n = 278) in 44 U.S. states responded to questions about staffing levels, budgets, access to needed personnel, and access to technology for selective breeding. Almost half of program leaders were nearing retirement age. Programs reported significantly declining estimates of hours spent on program activities by program leaders and technical support staff. On average, programs reported devoting 2.78 full‐time equivalent (FTE) to plant breeding research in the most recent fiscal year (including all types of personnel); for germplasm enhancement activities and variety development, mean estimated hours per program totaled 1.58 and 2.20 FTE, respectively. The median annual operating budget in the most recent fiscal year was US$150,000; the mean (average) annual operating budget was US$266,562. Budget and FTE means are somewhat skewed toward higher figures because of a few unusually large programs; almost 80% of programs reported annual budgets of US$400,000 or less. Institutional funds, federal competitive grants, and commodity check‐off programs accounted for 67% of program budgets. Many programs reported that budget shortfalls or uncertainty “endangered or severely constrained” or seriously constrained their ability to support key personnel, infrastructure and operations, and access to current technology for collecting, analyzing, and applying knowledge from phenotype and genotype data on plant materials in their programs.
Oxidative Esterification of 5‐Hydroxymethylfurfural with an N‐doped Carbon‐supported CoCu Bimetallic Catalyst
Authors: Liu Huai , Ding Ning , Wei Junnan , Tang Xing , Zeng Xianhai , Sun Yong , Lei Tingzhou , Fang Huayu , Li Tianyuan , Lin Lu 
Published: May 2020

AbstractThe direct fabrication of furan‐2,5‐dimethylcarboxylate (FDMC), a promising renewable monomer, from biomass‐derived 5‐hydroxymethylfurfural (HMF) is a cutting‐edge process. In this contribution, an elaborately designed N‐doped carbon‐supported CoCu bimetallic catalyst (CoxCuy‐NC; x/y=9:1, 7:3, 4:6, which represents the designed molar ratio of Co and Cu in the catalyst), which could offer a desirable FDMC yield of 95 % under mild and base‐free conditions (Co7Cu3‐NC, 2 bar O2, 80 °C, 4 h) is described for the oxidative esterification of HMF. Notably, an FDMC formation rate of 6.1 molFDMC molCo−1 h−1 was achieved over Co7Cu3‐NC, which represents the highest catalytic efficiency so far among Co‐based catalytic systems. It has been demonstrated that Cu‐doping in Co7Cu3‐NC catalyst brings about more active sites (Co‐Nx species) with stronger molecular oxygen activation ability. The increase of surface N content of Co7Cu3‐NC also improves basicity of the catalyst, which favors the hydrogen abstraction process during the HMF oxidative esterification reaction. These findings may pave an efficient and green way for the synthesis of sustainable bio‐based polymer monomers.
Metal–Acid Synergy: Hydrodeoxygenation of Anisole over Pt/Al‐SBA‐15
Authors: Shivhare Atal , Hunns James A. , Durndell Lee J. , Parlett Christopher M. A. , Isaacs Mark A. , Lee Adam F. , Wilson Karen 
Published: May 2020

AbstractHydrodeoxygenation (HDO) is a promising technology to upgrade fast pyrolysis bio‐oils but it requires active and selective catalysts. Here we explore the synergy between the metal and acid sites in the HDO of anisole, a model pyrolysis bio‐oil compound, over mono‐ and bi‐functional Pt/(Al)‐SBA‐15 catalysts. Ring hydrogenation of anisole to methoxycyclohexane occurs over metal sites and is structure sensitive; it is favored over small (4 nm) Pt nanoparticles, which confer a turnover frequency (TOF) of approximately 2000 h−1 and a methoxycyclohexane selectivity of approximately 90 % at 200 °C and 20 bar H2; in contrast, the formation of benzene and the desired cyclohexane product appears to be structure insensitive. The introduction of acidity to the SBA‐15 support promotes the demethyoxylation of the methoxycyclohexane intermediate, which increases the selectivity to cyclohexane from 15 to 92 % and the cyclohexane productivity by two orders of magnitude (from 15 to 6500 mmol gPt−1 h−1). Optimization of the metal–acid synergy confers an 865‐fold increase in the cyclohexane production per gram of Pt and a 28‐fold reduction in precious metal loading. These findings demonstrate that tuning the metal–acid synergy provides a strategy to direct complex catalytic reaction networks and minimize precious metal use in the production of bio‐fuels.
Coffee and tea consumption in the early adult lifespan and left ventricular function in middle age: the CARDIA study
Authors: Nwabuo Chike C. , Betoko Aisha S. , Reis Jared P. , Moreira Henrique T. , Vasconcellos Henrique D. , Guallar Eliseo , Cox Christopher , Sidney Stephen , Ambale‐Venkatesh Bharath , Lewis Cora E. , Schreiner Pamela J. , Lloyd‐Jones Donald , Kiefe Catarina I. , Gidding Samuel S. , Lima João A.C. 
Published: May 2020

AbstractAimsThe long‐term impact of coffee or tea consumption on subclinical left ventricular (LV) systolic or diastolic function has not been previously studied. We examined the association between coffee or tea consumption beginning in early adulthood and cardiac function in midlife.Methods and resultsWe investigated 2735 Coronary Artery Risk Development in Young Adults (CARDIA) study participants with long‐term total caffeine intake, coffee, and tea consumption data from three visits over a 20 year interval and available echocardiography indices at the CARDIA Year‐25 exam (2010–2011). Linear regression models were used to assess the association between caffeine intake, tea, and coffee consumption (independent variables) and echocardiography outcomes [LV mass, left atrial volume, and global longitudinal strain (GLS), LV ejection fraction (LVEF), and transmitral Doppler early filling velocity to tissue Doppler early diastolic mitral annular velocity (E/e´)]. Models were adjusted for standard cardiovascular risk factors, socioeconomic status, physical activity, alcohol use, and dietary factors (calorie intake, whole and refined grain intake, and fruit and vegetable consumption). Mean (standard deviation) age was 25.2 (3.5) years at the CARDIA Year‐0 exam (1985–1986), 57.4% were women, and 41.9% were African‐American. In adjusted multivariable linear regression models assessing the relationship between coffee consumption and GLS, beta coefficients when comparing coffee drinkers of <1, 1–2, 3–4, and >4 cups/day with non‐coffee drinkers were β = −0.30%, P < 0.05; β = −0.35%, P < 0.05; β = −0.32%, P < 0.05; β = −0.40%, P > 0.05; respectively (more negative values implies better systolic function). In adjusted multivariable linear regression models assessing the relationship between coffee consumption and E/e´, beta coefficients when comparing coffee drinkers of <1, 1–2, 3–4, and >4 cups/day with non‐coffee drinkers were β = −0.29, P < 0.05; β = −0.38, P < 0.01; β = −0.20, P > .05; and β = −0.37, P > 0.05, respectively (more negative values implies better diastolic function). High daily coffee consumption (>4 cups/day) was associated with worse LVEF (β = −1.69, P < 0.05). There were no associations between either tea drinking or total caffeine intake and cardiac function (P > 0.05 for all).ConclusionsLow‐to‐moderate daily coffee consumption from early adulthood to middle age was associated with better LV systolic and diastolic function in midlife. High daily coffee consumption (>4cups/day) was associated with worse LV function. There was no association between caffeine or tea intake and cardiac function.
Carotid arterial mechanics as useful biomarker of extracellular matrix turnover and preserved ejection fraction heart failure
Authors: Zhou Kevin Ning , Sung Kuo‐Tzu , Yen Chih‐Hsuan , Su Cheng‐Huang , Lee Ping‐Ying , Hung Ta‐Chuan , Huang Wen‐Hung , Chien Shih‐Chieh , Tsai Jui‐Peng , Yun Chun‐Ho , Chang Shun‐Chuan , Yeh Hung‐I , Hung Chung‐Lieh 
Published: May 2020

AbstractAimsWe aimed to investigate the functional alterations, diagnostic utilization, and prognostic implication of carotid arterial deformations in subjects with cardiovascular risk factors and heart failure (HF) with preserved ejection fraction (HFpEF).Methods and resultsAmong 251 prospectively participants (mean age 66.0 ± 9.8 years, 65.7% female) in a single centre between December 2011 and September 2014, carotid artery deformations including circumferential strain (CCS)/strain rate and radial strain were analysed by two‐dimensional speckle tracking. We further related these carotid artery deformation indices to HF biomarkers and cardiac structure and function by echocardiography and explored their prognostic values. Significant reductions of CCS, circumferential strain rate, and circumferential radial strain were observed across control (n = 52), high risk (n = 147), and HFpEF (n = 52) (trend P ≤ 0.001). Aging, hypertension, HFpEF, and higher pulse rate showed independent associations with reduced CCS by stepwise multivariate regressions (all P < 0.05). Higher CCS was inversely associated with better cardiac remodelling and functional indices, and lower multiple HF biomarkers (all P ≤ 0.005). After adjustment, higher CCS was independently associated with better global ventricular longitudinal strain/early diastolic strain rate, lower matrix metalloproteinase‐2, and N‐terminal propeptide of procollagen type III levels (adjusted coef: −0.08 and −19.9, all P < 0.05). During a median follow‐up of 1406 days (interquartile range: 1342‑1720 days), CCS less than 3.28% as a cut‐off had markedly higher HF events [Harrell's C: 0.72, adjusted HR: 2.20 (95% confidence interval: 1.24, 3.16), P = 0.008]. CCS also showed significantly improved risk prediction for HF over global ventricular longitudinal strain (net reclassification index: 48%, P = 0.001; integrated discrimination improvement: 1.8%, P < 0.001).ConclusionsCarotid artery deformations using two‐dimensional speckle‐tracking imaging showed novel mechanistic insights on functional arterial alterations reflecting coupled arterial‐ventricular pathophysiology. Utilization of such measure may further provide additive prognostic value to advanced myocardial functional assessment.
Does lack of control lead to conspiracy beliefs? A meta‐analysis
Authors: Stojanov Ana , Halberstadt Jamin 
Published: May 2020

AbstractPerceived lack of control is widely believed to motivate, at least partly, belief in conspiracy theories. We question the theoretical foundations of this belief and meta‐analyze existing published and unpublished studies to assess the overall effect of lack of control on conspiracy beliefs. The overall effect was small and not statistically significant (d = −0.05), and was not moderated by comparison group (baseline vs. control affirmation), type of manipulation used to threaten control, inclusion of a manipulation check, or sample type. However, the predicted effect of control was more likely to be observed when beliefs were measured in terms of specific conspiracy theories, rather than as general or abstract claims. Overall, the present studies to date offer limited support for the hypothesis that conspiracy beliefs arise as a compensatory control.
Detection of olive oil adulteration with vegetable oils by ultra‐performance convergence chromatography‐quadrupole time‐of‐flight mass spectrometry (UPC2‐QTOF MS) coupled with multivariate data analysis based on the differences of triacylglycerol compositions
Authors: Luo Yinghua , Gao Boyan , Zhang Yaqiong , Yu Liangli (Lucy) 
Published: May 2020

AbstractThree different vegetable oils, including soybean, corn, and sunflower oils, were differentiated from olive oil by using ultra‐performance convergence chromatography coupled with quadrupole time‐of‐flight (UPC2‐QTOF MS) and multivariate data analysis based on their differences in triacylglycerol compositions. Then, olive oil was adulterated by adding these three vegetable oils in 1%, 0.75%, and 0.5% (v/v), and the adulterated olive oils were differentiated from the pure olive oils using the similar analytical strategies but different data processing approaches. After that, the representative markers in differentiating the adulterations were selected, and a mathematical model was created to detect the olive oil adulteration based on these specific markers. These results indicated that UPC2‐QTOF MS coupled with multivariate data analysis is a sensitive and accurate method in detecting olive oil adulteration, even in 0.5% adulteration level (v/v). This method could be applied in olive oil adulteration detection, and potentially beneficial to the oil industry.
Doping amino acids with classical gas hydrate inhibitors to facilitate the hydrate inhibition effect at low dosages
Authors: Qureshi M Fahed , Khraisheh Majeda , Almomani Fares 
Published: May 2020

AbstractThe formation of gas hydrates in offshore subsea lines is a major flow assurance concern for the oil and gas industry. In this work, the thermodynamic hydrate inhibition (THI) effect of doping amino acids (AA) such as glycine (Gly), l‐alanine (Ala), and histidine (His) with classical gas hydrate inhibitors (CHI) such as methanol (Me), ethylene glycol (EG), and sodium chloride (NaCl) have been examined at diverse operating conditions. The experimental tests were carried out using rocking cell assembly [RC‐5] on pure methane gas at different pressure conditions (40–120 bars) using an equal ratio mixture (1:1) of AA and CHI at a low dosage (2 wt%). The computational three‐dimensional molecular models of AA and CHI were generated to examine electric charge distribution within these molecules and cognize the interaction mechanism between methane hydrates and AA. The experimental results indicate that Me and EG can synergize the THI effect of AA at a low dosage of 1 wt%. The AA doped with Me tend to provide better THI effect compared to AA doped with EG and NaCl. The experimental results also show that the doped AA Ala mixtures provide THI effect similar to pure CHI such as Me, EG, and NaCl at low dosage (2 wt%). © 2020 Society of Chemical Industry and John Wiley & Sons, Ltd.
Effects of lasmiditan on simulated driving performance: Results of two randomized, blinded, crossover studies with placebo and active controls
Authors: Pearlman Eric M. , Wilbraham Darren , Dennehy Ellen B. , Berg Paul H. , Tsai Max , Doty Erin G. , Kay Gary G. 
Published: May 2020

AbstractObjectiveTo evaluate the impact of lasmiditan, an oral, centrally‐penetrant, selective serotonin 1F (5‐HT1F) receptor agonist developed for the acute treatment of migraine, on simulated driving.MethodsHealthy adult volunteers enrolled in two randomized, placebo and active comparator‐controlled, crossover studies. Study 1 (N= 90) tested lasmiditan (50‐, 100‐, 200‐mg), alprazolam (1‐mg), and placebo at 1.5 hr post‐dose. Study 2 (N= 68) tested lasmiditan (100‐, 200‐mg), diphenhydramine (50‐mg, administered 2 hr pre‐assessments), and placebo at 8, 12 and 24 hr post‐dose. Driving performance was assessed using a validated driving simulator employing a 100 km driving scenario. Standard deviation of lateral position (SDLP), a measure of lane position control, was the primary endpoint.ResultsAssay sensitivity was confirmed by increased SDLP for active comparators at 1.5‐ and 8‐hr time points. Lasmiditan doses showed significant driving impairment versus placebo at 1.5 hr post‐dose. Lasmiditan doses were non‐inferior to placebo at 8 hr. Driving impairment was concentration‐dependent at 1.5 hr but not at 8 hr. Common adverse events were central nervous system‐related and mild‐to‐moderate in severity.ConclusionsLasmiditan was associated with impaired simulated driving performance at 1.5 hr post‐dose, but showed no clinically meaningful impairment at 8 hr post‐dose.
Water uptake of riparian plants in the lower Lhasa River Basin, South Tibetan Plateau using stable water isotopes
Authors: Rao Wenbo , Chen Xi , Meredith Karina T. , Tan Hongbing , Gao Man , Liu Jintao 
Published: May 2020

AbstractRiparian plants can adapt their water uptake strategies based on climatic and hydrological conditions within a river basin. The response of cold‐alpine riparian trees to changes in water availability is poorly understood. The Lhasa River is a representative cold‐alpine river in South Tibet and an under‐studied environment. Therefore, a 96 km section of the lower Lhasa River was selected for a study on the water‐use patterns of riparian plants. Plant water, soil water, groundwater and river water were measured at three sites for δ18O and δ2H values during the warm‐wet and cold‐dry periods in 2018. Soil profiles differed in isotope values between seasons and with the distance along the river. During the cold‐dry period, the upper parts of the soil profiles were significantly affected by evaporation. During the warm‐wet period, the soil profile was influenced by precipitation infiltration in the upper reaches of the study area and by various water sources in the lower reaches. Calculations using the IsoSource model indicated that the mature salix and birch trees (Salix cheilophila Schneid. and Betula platyphylla Suk.) accessed water from multiple sources during the cold‐dry period, whereas they sourced more than 70% of their requirement from the upper 60–80 cm of the soil profile during the warm‐wet period. The model indicated that the immature rose willow tree (Tamarix ramosissima Ledeb) accessed 66% of its water from the surface soil during the cold‐dry period, but used the deeper layers during the warm‐wet period. The plant type was not the dominant factor driving water uptake patterns in mature plants. Our findings can contribute to strategies for the sustainable development of cold‐alpine riparian ecosystems. It is recommended that reducing plantation density and collocating plants with different rooting depths would be conducive to optimal plant growth in this environment.
UBC12‐mediated SREBP‐1 neddylation worsens metastatic tumor prognosis
Authors: Heo Mi Jeong , Kang Sung Hyun , Kim Yun Seok , Lee Jung Min , Yu Jinha , Kim Hong‐Rae , Lim Hyesol , Kim Kyoung Mee , Jung Joohee , Jeong Lak Shin , Moon Aree , Kim Sang Geon 
Published: May 2020

AbstractActivation of sterol regulatory element‐binding protein 1 (SREBP‐1), a master lipogenic transcription factor, is associated with cancer metabolism and metabolic disorders. Neddylation, the process of adding NEDD8 to its substrate, contributes to diverse biological processes. Here, we identified SREBP‐1 as a substrate for neddylation by UBC12 and explored its impact on tumor aggressiveness. In cell‐based assays, SREBP‐1 neddylation prolonged SREBP‐1 stability with a decrease in ubiquitination. Consequently, NEDD8 overexpression facilitated proliferation, migration, and invasion of SK‐Hep1 liver tumor cells. MLN4924 (an inhibitor of the NEDD8‐activating enzyme‐E1) treatment or UBC12 knockdown prevented SREBP‐1 neddylation and tumor cell phenotype change. This effect was corroborated in an in vivo xenograft model. In human specimens, SREBP‐1, UBC12, and NEDD8 were all upregulated in hepatocellular carcinoma (HCC) compared to nontumorous regions. Moreover, SREBP‐1 levels positively correlated with UBC12. In GEO database analyses, SREBP‐1 levels were greater in metastatic HCC samples accompanying UBC12 upregulation. In HCC analysis, tumoral SREBP‐1 and UBC12 levels discriminated overall patient survival rates. Additionally, MLN4924 treatment destabilized SREBP‐1 in MDA‐MB‐231 breast cancer cells and in the tumor cell xenograft. SREBP‐1 and UBC12 were also highly expressed in human breast cancer tissues. Moreover, most breast cancers with lymph node metastasis displayed predominant SREBP‐1 and UBC12 expressions, which compromised overall patient survival rates. In summary, SREBP‐1 is neddylated by UBC12, which may contribute to HCC and breast cancer aggressiveness through SREBP‐1 stabilization, and these events can be intervented by MLN4924 therapy. Our findings may also provide potential reliable prognostic markers for tumor metastasis.
First‐principles Studies of Band Gap Engineering in Ferroelectric Oxides
Authors: Grinberg Ilya 
Published: May 2020

AbstractIn the last decade there has been a resurgence of activity in the field of photoferroelectrics with a focus on the studies of oxides. Ferroelectric (FE) materials have a spontaneous switchable polarization that can lead to interesting light‐matter interactions such as the bulk photovoltaic effect. While a wide range of compositions has been explored for ferroelectrics, until recently, FE oxides were considered to be capable of absorbing UV light only. Playing a key role in the advance of the field, first‐principles calculations have guided the experimental materials discovery efforts that have identified a wide variety of visible‐light‐absorbing oxides. First‐principles research efforts have also achieved considerable progress in revealing the interplay between the composition, structure and light absorption properties in these materials, and it is now understood that even small changes in the local environment can lead to large changes in band gap character and magnitude. Here, we survey the first‐principles efforts following different band‐gap engineering strategies and the advances in the computational methods that have been driven by these studies.
Treated Oil Shale Ashes as a Substitute for Natural Aggregates, Sand, and Cement in Concrete
Authors: Nov Sarit , Cohen Haim , Knop Yaniv 
Published: May 2020

AbstractOil shales are rocks that contain organic matter and are used as a low‐grade fuel for energy production. The oil shale combustion process produces large quantities of ash as combustion wastes. These residues contain a high concentration of calcium anhydrite (CaSO4) and calcium carbonate (CaCO3), which can be utilized to neutralize acidic wastes (e. g., wastes from the phosphate industry) .Using untreated oil shale bottom ash as partial substitutes for aggregates, natural sand, and cement in concrete mixtures has resulted in a significantly decreased performance of the concrete mixtures. However, by blending the oil shale with acidic materials, the concrete properties improved, as manifested by the development of compressive strength and the workability of the concrete mixtures. In the current study, it was shown that treatment of the oil shale ash with the acidic waste of the Israeli phosphate industry or with phosphoric acid significantly improves the properties of the concrete mixtures, by partial replacement of the natural aggregates and sand by the treated oil shale ash.