bluuebunny/crossref_metadata_2025_split huggingface dataset:
КНИГА БЫТИЯ И СОВРЕМЕННАЯ ПСИХОЛОГИЯ: СОВПАДЕНИЯ И РАСХОЖДЕНИЯ (рос)
Authors: Левит Леонид 
Published: April 2020

В статье рассматриваются совпадения и различия между библейским сюжетом о первородном грехе и результатами, выявленными современной экспериментальной наукой. Так, показано, что подав­ляю­щее большинство людей действительно подвержено закономерностям, которые трактуются религией в качестве божественного наказания за вкушение плодов с дерева познания. Речь идёт о повышенной уязвимости к негативу, быстрой адаптации к позитиву, трансформации кратковременного «добра» в дол­го­временное «зло» и восприятии труда в качестве тягостной необходимости. Таким образом, отмечаемая в христианских источниках «большая склонность человека к злу, нежели к добру» имеет определённые научные подтверждения. Создаётся впечатление, что над «массовым» человеком действительно тяго­теют негативные закономерности, которые можно истолковывать как следствие «божественного нака­зания». По контрасту, свободно выбираемая активность одарённого индивида подчинена противопо­лож­ным закономерностям: получению качественно особых (в том числе, потоковых) позитивных переживаний благодаря напряжению сил, отсутствию адаптации к позитиву с одновременной повышенной устой­чивостью к негативной информации и общераспространённым стрессам, развитию внутреннего потен­циала и успешной самореализации. В частности, последнее наиболее ярко выражено в творческой актив­ности учёного, продолжающего «срывать плоды с дерева познания», тем самым как бы «нарушая» бо­жественные запреты и общечеловеческие закономерности. В эпоху, когда наука не обнаружила следов «внешнего» источника смысла жизни (включая божественный замысел), на современного думающего человека ложится личная ответственность за создание персональной смысловой конструкции
Relación entre nivel de condición física y percepción de la calidad de vida relacionada con la salud en adolescentes del sureste español
Authors: Nieto-López Laura , García-Cantó Eliseo , Rosa-Guillamón Andrés 
Published: April 2020

Introducción. La condición física relacionada con la salud (CFS) es considerada como uno de los factores que determinan el concepto de calidad de vida relacionada con la salud (CVS).Objetivo. Analizar la relación entre el nivel de CFS y la percepción de la CVS en adolescentes españoles.Materiales y métodos. Estudio multicéntrico realizado en una población de 1 037 adolescentes (15.52±1.11 años) del sureste de España (Región de Murcia). La CFS y la CVS se evaluaron mediante la batería COFISA y el Cuestionario de Salud SF-36, respectivamente.Resultados. La prueba MANOVA mostró que los varones tuvieron un mejor rendimiento físico global (p<0.001). Respecto a la CVS, las mujeres tuvieron una mejor percepción en la dimensión salud general (p=0.011), mientras que la percepción de los varones fue mejor en las dimensiones rol emocional (p=0.010) y salud mental (p<0.001). Los adolescentes con mayor nivel CFS tuvieron valores superiores en la percepción global de la CVS (p<0.001 en todas las variables).Conclusión. La asociación entre niveles altos de CFS y puntajes superiores de percepción de la CVS hace necesario establecer estrategias y acciones que busquen aumentar los niveles de participación de los jóvenes en actividades físicas y deportivas.
Clinical outcomes in hypertension patients after coronary stenting due to exertional angina
Authors: Akhtereyev R. N. , Galyavich A. S. , Baleeva L. V. , Galeeva Z. M. 
Published: April 2020

Aim. To study clinical outcomes in hypertension patients after coronary stenting due to exertional angina.Material and methods. The study included 214 patients with class 3 stable angina and hypertension. All patients underwent coronary angiography followed by elective stenting. Clinical outcomes were assessed on average after 44 months of outpatient follow-up.Results. During the follow-up period, 43% of patients retained class III angina; the decrease in systolic (SBP) and diastolic blood pressure (DBP) was 18and 14-mm Hg, respectively. There were 35 cases of myocardial infarction (MI) in this category of subjects. We revealed that 57% of patients had a progression of angina: from class III to class IV; the decrease in SBP and DBP was 10and 18-mm Hg, respectively. There were 110 cases of MI and 10 cases of acute cerebrovascular accident in these patients.Conclusion. Inadequate control of SBP in patients after stenting due to stable exertional angina leads to a greater number of complications, mainly myocardial infarction.
La Caja-Tambora Montuvia
Authors: Macías Ferrin Luis Andrés 
Published: April 2020

La caja tambora es un instrumento musical vernáculo de percusión, que surge de la necesidad de crear nuevas memorias culturales ligadas a una tendencia contemporánea moderna basadas en la musicalización de la tradición oral montuvia. Este instrumento está elaborado de maderas populares del campo manabita así mismo tiene incrustaciones de bambú. Su estructura es octagonal debido a la riqueza acústica que permite ese diseño y a la representación literaria octosílaba en la composición del amorfino, asumiendo así una identidad e imagen representativa. La sonoridad del instrumento es muy orgánica y conjuntamente con la ejecución del percusionista recrea sonidos agudos por su lado izquierdo y graves-medios por su lado derecho con un orificio de desfogue de sonido en la parte superior. Llevar la célula rítmica adoptada por los montubios para el género musical amorfino es la función de este instrumento dentro de esta cultura musical de la costa ecuatoriana.
Analisis Sentimen Pada Media Sosial Twitter Terhadap Tokoh Publik Peserta Pilpres 2019
Authors: Cahyani Rafika Rafika , Cahyani Rafiqa 
Published: April 2020

<p>Di<em> Indonesia twitter menjadi salah satu situs microblogging yang sangat digemari oleh masyarakat. Masyarakat sudah terbiasa dalam menyampaikan pendapat atau opininya dalam media sosial termasuk dalam twitter, hal ini digunakan dalam menanggapi suatu kejadian atau peristiwa yang terjadi di lingkungan mereka. Pada penelitian ini dilakakan berbagai proses yaitu crawling data dari twitter, pre prosesing data teks, Naïve Bayes Classifier untuk probabilitas teks terhadap sentimen, dan Simple Wighted Product Model untuk perangkingan sentimen. Dari hasil percobaan tersebut dapat diperoleh hasil akurasi terbaik yaitu menggunakan proporsi ketiga dengan pengambilan data secara acak dengan mendapatkan nilai rata rata akurasi sebesar 99,75%. Sedangkan untuk perangkingan sentimen terhadap masing masing tokoh publik dapat di ketahui yang memperoleh peringkat pertama yaitu KH Ma’ruf Amin , yang kedua yaitu Sandiaga Salahudin Uno, yang ketiga yaitu Joko Widodo, dan yang terakhir yaitu Prabowo Subianto</em></p>
O retrocesso no combate da LGBTfobia no Brasil
Authors: Gonzaga Taynan Matheus Sousa , Gallas Ana Kelma Cunha 
Published: April 2020

A escola é um dos espaços onde a população LGBT sofre preconceito e isso continua sendo reforçado pelos profissionais desse ambiente e pela falta de preparo dos mesmos para lidarem com essa problemática Este trabalho se caracteriza como uma pesquisa qualitativa, adotando-se como metodologia a revisão da literatura. Este trabalho se configura como uma pesquisa qualitativa, onde procuramos discutir o processo de preconceito e exclusão desses alunos e qual o motivo que gera a evasão dos mesmos da escola. O presente artigo concluiu que ainda há muito a ser superado pelo sistema educacional para que as políticas públicas de gênero e sexualidade sejam efetivadas.
O homem racional Versus o homem intuitivo
Authors: Silva Fernando Xavier 
Published: April 2020

Trata-se de uma resenha das obras Sobrinho de Rameau de Denis Diderot (1713-1784), Sobre a Verdade e Mentira no sentido Extra-Moral de Friedrich Nietzsche (1873) e A construção das ciências: introdução à filosofia e á ética das ciências de Gerárd Fourez (1995). Os textos foram lidos com base nas seguintes questões: Quais são as bases de sustentação do conhecimento?; O que é a verdade e se é possível alcançá-la de forma objetiva; O que é a ciência e o que ela representa na busca pela verdade e o conhecimento? e Quais as possibilidades da linguagem na busca pelo conhecimento? Concluiu-se que o que Diderot caracteriza como idiotismo aparenta-se com os valores morais seguidos pelo instinto de rebanho nos indivíduos de Nietzsche. Para Fourez observar é sempre representar e na representação nunca se obtém do objeto sua verdadeira essência. Desconstruir conceitos, apreender o aspecto fluido e mutável das coisas e dos valores, seria essa a linha mestra dos textos tratados neste trabalho.
Editorial
Authors: Sanchez Gamboa Silvio 
Published: April 2020

Editorial do v.11, n, 2 de 2019.
Apresentação dos nove (9) trabalhos selecionados, compondo as seção de numero temático (3), artigos de fluxo contínuo (4) , formação filosófica (1) e resenhas (1). Agradecimentos aos pesquisadores que participaram na edição como avaliadores, revisores e coordenadores da edição.
Gene locus polymorphisms and expression levels of interleukin-1 in lumbar disc disease: a meta-analysis and immunohistochemical study
Authors: Jiang Hua , Xiao Qianyi , Zhang Ruijun , Wang Jiaqi , Meng Dihua , Zhan Xinli , Wei Qingjun 
Published: April 2020

Abstract
Background

To investigate the association between interleukin (IL)-1α (rs1800587), IL-1β (rs1143634) and IL-1RN variable number tandem repeat (VNTR) polymorphisms, expression levels and lumbar disc disease (LDD).

Methods

All relevant articles were searched from 4 databases including PubMed, Embase, Web of Science and China National Knowledge Infrastructure (CNKI). Odds ratios (OR) with 95% conﬁdence intervals (CI) were calculated to evaluate the association between IL-1 gene locus polymorphisms (rs1800587 in IL-1α, rs1143634 in IL-1β, VNTR in IL-1RN) and LDD susceptibility. Statistical analysis was conducted by Review Manager (Revman) 5.31 software. Furthermore, qRT-PCR and immunohistochemistry (IHC) were performed to evaluate IL-1α, IL-1β and IL-1RN expressions in the normal and degenerated disc.

Results

A total of 15 case-control studies (1455 cases and 2362 controls) were included in our meta-analysis. The pooled results suggested that IL-1α rs1800587 polymorphism was associated with an increased risk of LDD in overall population (T vs. C, OR=1.21, 95%CI=1.04-1.40, P=0.01). The subgroup analysis found a significant association between IL-1β rs1143634 polymorphism and LDD in Asian population (T vs. C, OR=0.61, 95%CI=0.39-0.96, P=0.03). Results of qRT-PCR and IHC demonstrated that expressions of IL-1α and IL-1-β were significantly increased in the degenerated disc. (all P<0.05)

Conclusion

IL-1α rs1800587 and IL-1β rs1143634 polymorphisms were significantly associated with LDD in overall population and in Asian population, respectively. The increased expression levels of IL-1α and IL-1β may be the important risk factors for LDD.
The effect of miR-23b-3p on growth hormone in pituitary cells of Yanbian yellow cattle
Authors: Ji Jiuxiu , Lou Angang , Zhang Rui , Jin Taihua , Xiang Siyu , Cui Changyan , Yu Longzheng , guan lizeng 
Published: April 2020

Abstract
Background There is a relationship between miR-23b-3p and GH in pituitary of Yanbian yellow cattle. However, the specific mechanism of the effect of miR-23b-3p on GH in pituitary of Yanbian yellow cattle is still unclear.This study aimed to evaluate the effect of miR-23b-3p on growth hormone (GH) in pituitary cells of Yanbian yellow cattle. Methods The primary culture of Yanbian yellow cattle pituitary cells was carried out, and mimics (miR-23b-3p-mi group), mimics reference substance (NC group), inhibitor (miR-23b-3p-in group) and inhibitor reference substance (iNC group) of miR-23b-3p were transfected into the established pituitary primary cells. After 48 h, the cells were collected and the total RNA and protein were extracted.The mRNA transcription and protein expression level of GH and miR-23b-3p target genes were detected by real time fluorescence quantitative PCR (qPCR) and Western blot, respectively. The target relationship of miR-23b-3p was validated by double luciferase reporter gene system. Results Compared with the NC control group, GH mRNA transcription and protein expression level in pituitary cells of Yanbian yellow cattle was significantly decreased by adding miR-23b-3p minics ( P <0.01), while compared with the iNC control group, GH mRNA transcription and protein expression level were significantly increased by adding miR-23b-3p inhibitor( P <0.05). The result of bioinformatics analysis and double luciferase reporter gene system validation proved that miR-23b-3p targeted 3'UTR of pituitary specific transcription factor 1 (POU1F1). Compared with the NC control group, POU1F1 mRNA transcription and protein expression level were significantly inhibited by the addition of miR-23b-3p minics ( P <0.01), while compared with the iNC control group, POU1F1 mRNA transcription and protein expression level were significantly increased by the addition of miR-23b-3p inhibitor ( P <0.01). Conclusions miR-23b-3p could regulate GH in pituitary cells by regulating POU1F1 gene.
Clinical value of oblique lateral lumbar interbody fusion combined with posterior navigation and long segment internal fixation in the treatment of degenerative scoliosis
Authors: Lou Yuliang , Fei Hui , Hong Feng , Wang Canfeng , Quan Renfu 
Published: April 2020

Abstract
Background ：To assess the short-term clinical outcomes of oblique lateral lumbar interbody fusion (OLIF) combined with multiple level fixation with the guidance of posterior "O" arm CT navigation for degenerative scoliosis. Methods ：A total of 15 patients (3 males and 12 females; average age: 62.2±5.3 years) with degenerative scoliosis were enrolled in our study. All patients were treated with OLIF combined with posterior "O" arm CT navigation and long segment (T 10 -L 5 ) internal fixation during Apr. 2016 and Dec. 2017. Collected perioperative data included surgery time, blood loss, excellent rate of intraoperative pedicle screw. Coronal Cobb angle, lumbar lordosis (LL), intervertebral space height, sagittal balance (SVA) were measured by plain radiograph. Accuracy of pedicle screw placement and intervertebral fusion was investigated with postoperative CT. Visual analogue scale (VAS) and Oswestry disability index (ODI) were used to evaluate the clinical efficacy of surgery. Results ： All patients were followed for 12-25 months (16.5±5.3 months).The OLIF operation time was (98.7±16.8) min, and the blood loss was (50.2±10.7) ml. The posterior "O" arm CT-navigated long segment internal fixation was (101.5 ± 23.4) min, and the blood loss was (63.1 ± 19.7) ml. The total operation time was (200.2±40.2) min, and the blood loss was (113.3±30.4) ml. Coronal Cobb angle, LL, intervertebral space height, SVA, VAS, ODI at the last follow-up were 5.5°± 3.1°, 39.3°± 9.1°, (10.9±1.2) mm, (25.1±10.9) mm, (1.3± 0.8)and(15.8±4.5)%, respectively, showing statistically significant differences ( P <0.05). The "O" arm CT navigation has 240 nails, and the excellent rate of three-dimensional scanning of the "O" arm during surgery is 96%. Lumbar CT showed lumbar fusion at the 6-month postoperative period. Conclusion ： The short-term clinical outcomes of oblique lateral lumbar interbody fusion combined with posterior "O" arm CT-navigated long segment internal fixation for degenerative scoliosis are satisfactory, with advantages like minimal invasiveness, accurate navigation, high bone fusion rate and few complications. Keywords ：Scoliosis; Surgery,computer-assisted; Spine fusion
Molecular Imaging in the selection and evaluation of response in patients treated with Radium-223 in six different solid tumors: A single center experience
Authors: MEDINA-ORNELAS SEVASTIAN , GARCIA-PEREZ FRANCISCO OSVALDO , Alvarez-Avitia MIGUEL , SOBREVILLA-MORENO NORA , SANTANA-RIOS ZAEL , GARCIA-ORTEGA DORIAN , BARRON-BARRON FELICIANO , ARRIETA-RODRIGUEZ OSCAR 
Published: April 2020

Abstract
Objective: Evaluate impact after 223 Ra therapy and 18 F-NaF (sodium fluoride) PET/CT in the selection and evaluation of response in patients treated with 223 Ra in six different solid tumors. Material and Methods: Twenty patients with metastatic castration-resistant prostate cancer (mCRPC), seven metastatic castration-sensitive prostate cancer (mCSPC), three osteosarcoma, two breast cancer, two non-small cell lung cancer (NSCLC), one chondrosarcoma, one chordoma and one patient lung neuroendocrine carcinoma. Three groups of study were defined according total skeletal tumor-burden obtained by 18 F-NaF PET/CT, group 1 <1000cm 3 , group 2 1001–2999cm 3 and group 3 >3000cm 3 VOI´s. A semi-quantitative comparison was performed measuring the SUVmax values of VOIs values in all bone metastases in each patient previous to receive the first cycle of 223 Ra, after 3 and 6 cycles. Results: 30 patients non-progress disease was documented after 24±4 weeks. 8 patients progress disease was presented after three cycles of 223 Ra, two patients with osteosarcoma, four patients with mCRPC, one patient with chondrosarcoma and one patient with NSCLC. Group 1 patients showed better response rates compared to group 3 (p<0.05). Group 2 patients who showed improvement clinical and radiological, had prostate malignancies compared to those in the same group, but non-prostatic malignancies (p<0.05). No significant difference in group 2 patients compared to group 3 (p<0.67). Symptomatic skeletal-related event was observed in 7 patients. Conclusion: 18 F-NaF PET/CT allows to identify patients who show osteoblastic bone activity and discard or confirm progression in the interval PET/CT image, allowing change of treatment, reducing costs. High tumor-burden strongly suggests a poor response to treatment
Synergic effect of diabetes mellitus and H. pylori infection on proliferation of cells via downregulating the expression of PTEN by hypermethylating its promoter region
Authors: Lu Huibin , Han Xinwei , Ren Jianzhuang , Ren Kewei , Li Zongming , Zhang Quanhui 
Published: April 2020

Abstract
Background It has been reported that CagA of H. pylori reduced the expression of PTEN by enhancing its promoter methylation. Furthermore, DM may also promote the methylation status of PTEN, a tumor suppressor gene in Gastric cancer. It is intriguing to explore whether DM may strengthen the tumorigenic effect of HP by promoting the methylation of PTEN promoter and whether the administration of metformin may reduce the risk of GC by suppressing the methylation of PTEN promoter. Methods Bisulfite sequencing PCR was performed to measure the DNA methylation of PTEN promoter in GC patients and HGC-27 cells treated under different conditions. Quantitative real-time PCR was carried out to measure the expression of PTEN mRNA. Immunohistochemistry and Western blot were used to evaluate the expression of PTEN protein. Immunofluorescence and flow cytometry were performed to analyze the apoptosis of GC tissue samples and HGC-27 cells treated under different conditions. MTT assay was carried out to examine the proliferation of HGC-27 cells. Results DNA methylation of PTEN promoter was synergetic enhanced by HP infection and Diabetes mellitus in patients with Gastric cancer. Accordingly, the expression of PTEN was suppressed in GC patients with HP infection and DM. Furthermore, cell apoptosis was decreased in GC patients with HP infection and DM. Metformin showed an apparent effect on maintaining CagA induced elevation of PTEN promoter methylation, thus attenuating the PTEN expression, increasing the proliferation and suppressing the apoptosis of HGC-27 cells. Conclusion In this study, we collected GC tumor tissues from GC patients with or without DM/HP to compare their PTEN methylation and expression while testing the effect of Metformin on the methylation of PTEN promoter. Our study provided evidence for the mechanism underlying the therapeutic role of Metformin in GC treatment.
Barriers to recruitment into a multi-site randomized controlled trial comparing the effectiveness of specialty outpatient versus nurse-led telephonic palliative care of older adults with advanced illness
Authors: Brickey Julia A , Cho Jeanne , Flannery Mara , Grudzen Corita R. , Investigators EMPallA 
Published: April 2020

Abstract
Background Emergency department (ED) visits among older adults are common near the end of life. Palliative care has been shown to reduce ED visits and to increase quality of life among patients, but recruitment into these programs is often challenging. Methods A multi-site randomized controlled trial investigating two modes of community-based palliative care delivery for patients in the ED who are discharged home. Research coordinators monitored factors that prevented eligibility and enrollment by screening electronic health records to identify and recruit eligible patients and their caregivers. Reasons for ineligibility and non-participation were documented. Results Among the 7,091 patients who met the age and disease qualifier, 4,292 (60.5%) were deemed ineligible due to hospital admission. Additional reasons for ineligibility included previous palliative care (919 [13%]) or residence in a nursing facility (462 [6.5%]). Of the 695 patients who were eligible, 298 were enrolled, yielding an enrollment rate of 43% (range of 9% to 80% across all sites). Of the 397 eligible patients who did not participate, 180 (45.3%) refused due to barriers related to illness severity. Patients commonly refused due to misconceptions/stigma related to palliative care (118 [29.7%]). One-hundred fifteen patients (29%) refused due to the mode of palliative care delivery. Conclusions Hospital admission from the ED proved to be the most significant barrier to eligibility. Eligible patients often refused participation due to the nature of their illness, misconceptions about palliative care, and concerns about being able to attend clinic visits if assigned to the outpatient arm.