bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chromatin remodeler Brahma safeguards canalization in cardiac mesoderm differentiation
Authors: Hota Swetansu K. , Blair Andrew P. , Rao Kavitha S. , So Kevin , Blotnick Aaron M. , Desai Ravi V. , Weinberger Leor S. , Kathiriya Irfan S. , Bruneau Benoit G. 
Published: June 2020

SUMMARYDifferentiation proceeds along a continuum of increasingly fate-restricted intermediates, referred to as canalization1–4. Canalization is essential for stabilizing cell fate, but the mechanisms underlying robust canalization are unclear. Here we show that deletion of the BRG1/BRM-associated factor (BAF) chromatin remodeling complex ATPase geneBrm(encoding Brahma) results in a radical identity switch during directed cardiogenesis of mouse embryonic stem cells (ESCs). Despite establishment of well-differentiated precardiac mesoderm,Brm-null cells subsequently shifted identities, predominantly becoming neural precursors, violating germ layer assignment. Trajectory inference showed sudden acquisition of non-mesodermal identity inBrm-null cells, consistent with a new transition state inducing a fate switch referred to as a saddle-node bifurcation3,4. Mechanistically, loss ofBrmprevented de novo accessibility of cardiac enhancers while increasing expression of the neurogenic factor POU3F1 and preventing expression of the neural suppressor REST.Brmmutant identity switch was overcome by increasing BMP4 levels during mesoderm induction, repressingPou3f1and re-establishing a cardiogenic chromatin landscape. Our results reveal BRM as a compensable safeguard for fidelity of mesoderm chromatin states, and support a model in which developmental canalization is not a rigid irreversible path, but a highly plastic trajectory that must be safeguarded, with implications in development and disease.
Performance characteristics of the ID NOW COVID-19 assay: A regional health care system experience
Authors: Ghofrani Mohiedean , Casas Mary T. , Pelz Robert K. , Kroll Catherine , Blum Natalie , Foster Scott D. 
Published: June 2020

AbstractObjectivesWe compared the Abbott ID NOW COVID-19 point-of-care test (POCT) with polymerase chain reaction (PCR)-based methods to assess the claimed sensitivity and specificity of POCT and to optimize test utilization in our regional health care system.MethodsAssuming PCR to be the gold standard, we used a convenience sampling of mostly symptomatic COVID-19 suspect hospital patients who had already been tested for internal validation and guideline development purposes by both PCR and POCT to calculate the sensitivity and specificity of POCT with Clopper-Pearson 95% confidence intervals (CI).ResultsDuring the study period, 113 paired patient samples met eligibility criteria. The sensitivity of POCT in this population was calculated to be 94.1% [CI 71.31-99.85%] and the specificity was 99.0% [CI 94.33-99.97%].ConclusionsBased on the lower sensitivity of POCT and the estimated prevalence of COVID-19 in our symptomatic and asymptomatic hospital patients, we recommend a two-pronged testing approach in which COVID-19 suspect patients are tested by the more sensitive PCR, while asymptomatic patients with a low pre-test probability of infection are tested with POCT supplemented by PCR confirmation of positive results. Furthermore, isolation decisions should not be based on POCT results alone.
Covid-19 trajectories – Monitoring pandemic in the worldwide context
Authors: Loeffler-Wirth Henry , Schmidt Maria , Binder Hans 
Published: June 2020

AbstractBackgroundCovid-19 pandemic is developing worldwide with common dynamics but also with partly marked differences between regions and countries. They are not completely understood, but presumably, provide one clue to find ways to mitigate epidemics until exit strategies to its eradication become available.MethodWe provide a monitoring tool available atwww.izbi.de. It enables inspection of the dynamic state of the epidemic in 187 countries using trajectories. They visualize transmission and removal rates of the epidemic and this way bridge epi-curve tracking with modelling approaches.ResultsExamples were provided which characterize state of epidemic in different regions of the world in terms of fast and slow growing and decaying regimes and estimate associated rate factors. Basic spread of the disease associates with transmission between two individuals every two-three days on the average. Non-pharmaceutical interventions decrease this value to up to ten days where ‘complete lock down’ measures are required to stop the epidemic. Comparison of trajectories revealed marked differences between the countries regarding efficiency of measures taken against the epidemic. Trajectories also reveal marked country-specific dynamics of recovery and death rates.ConclusionsThe results presented refer to the pandemic state in May 2020 and can serve as ‘working instruction’ for timely monitoring using the interactive monitoring tool as a sort of ‘seismometer’ for the evaluation of the state of epidemic, e.g., the possible effect of measures taken in both, lock-down and lock-up directions. Comparison of trajectories between countries and regions will support developing hypotheses and models to better understand regional differences of dynamics of Covid-19.
Cross-cultural insights on lived experiences of opioid users among young adults
Authors: Zaman Sabir , Irfan Shahid , Hussain Basharat , Nawaz Muhammad Tahir , Khalid Shazia 
Published: June 2020

Purpose
There is increased social discussion of the emerging issues of opioid use, health and well-being of young adults within contemporary Asian society. The purpose of this study is to contribute new knowledge of opioid-using young adults through ethnographic perspectives of the five main cultures of Pakistan. Furthermore, it tried to explore the values of opioid users.

Design/methodology/approach
It is a qualitative study. Semi-structured interview and observation techniques were used to gain the participants’ information, in a non-judgmental environment. Observation and life focus history interview methodology were used for data collection. The sample consisted of 18 male opioid users (approximately three from each area including: Punjab, Khyber Pakhtoon Khah, Balochistan, Sindh, Gilgit Baltistan and Azad Jammu and Kashmir). An interview script was used in interviews after written informed consent. After the detailed interview and observation of non-verbal behaviours, the researchers analysed the data by using the content analysis of qualitative method.

Findings
The result showed that poor relationships, conflicts over property, lack of social support and family problems increased with the use of opioids by individuals. The individual’s mental health, such as hopelessness, curiosity, mistrust and lack of interest in social activities, was the major cause of opioid addiction. Moreover, peer influences and friends may also have played contributing roles in opioids use among men.

Research limitations/implications
The current study added to the understanding of the relationship of different environmental, behavioural and social factors involved in developing opioid use among young individuals. The homogeneity of the sample may have weakened the generalisability of the findings of the study as all participants in the study were male.

Practical implications
Clinicians and allied professionals have shown a great interest in early intervention with opioid users. At the same time, there is a lack of qualitative studies exploring the lived experiences of young opioid users. That is why this study was done, to empower counsellors.

Social implications
Opioids, including heroin, have strong addictive tendencies. They are easily available, particularly in unplanned urban areas of Pakistan. The present study tried to understand the lived experiences and beliefs of opioid users belonging to different cultures of Pakistan.

Originality/value
At the same time, there is a lack of qualitative studies exploring the lived experiences of adult opioid users. Therefore, this study presented 18 interview-based facts from the opioid users belonging to different areas of Pakistan residing in capital of Pakistan. The content of these vignettes was examined in the context of an ethnographic perspective, as it has a strong connection and contribution to drug abuse.
Inclusive leadership: new age leadership to foster organizational inclusion
Authors: Kuknor Sunaina Chetan , Bhattacharya Shubhasheesh 
Published: June 2020

Purpose
This paper aims to investigate the relationship between inclusive leadership (IL) and organizational inclusion (OI) in literature and explores the contribution of IL and OI in human resources development (HRD).

Design/methodology/approach
The systematic literature review was undertaken from peer-reviewed journals. In total, 68 articles were critically analyzed to be included in the review highlighting the relationship between IL and OI.

Findings
The paper provides insights into leader behaviors that foster IL and how it differs from other styles of leadership. The paper also proposes a theoretical model to show the relationship between IL and OI.

Practical implications
The study will facilitate creating awareness in practitioners and academicians who think inclusion is mostly concerned with disabled learners, which is misleading. The paper will help the concerned stakeholders to formulate HRD practices to foster an inclusive culture at work.

Originality/value
The paper explores an area less researched and is among the few review papers investigating through the relationship between IL and OI and how they impact HRD practices in an organizational set-up.
Does anti-corruption disclosure affect banking performance?
Authors: Nobanee Haitham , Atayah Osama F. , Mertzanis Charilaos 
Published: June 2020

Purpose
This paper aims to test the levels of anti-corruption disclosure and its implication on the banking performance of both conventional and Islamic banks listed on the Abu Dhabi Securities Exchange and Dubai Financial Market.

Design/methodology/approach
The authors have used the content analysis to identify the levels of anti-corruption disclosure in the banks’ annual reports. They have also used the two-steps generalized method of moments (GMM) regression applied to dynamic panel data analysis to examine the effect of the anti-corruption disclosure on the banking performance.

Findings
The empirical results show that the anti-corruption disclosure is at low levels for all banks and conventional and Islamic banks samples. The results also show no significant differences in the anti-corruption disclosure between Islamic and conventional banks. The results of the two-steps GMM regression applied to dynamic panel data analysis show a negative and significant impact of the levels of anti-corruption disclosure on the bank’s performance for both all banks and conventional banks; the results of the dynamic panel data analysis show an insignificant impact of anti-corruption discloser for the Islamic banks' sample.

Practical implications
The findings recommended a comprehensive framework of anti-corruption disclosure to the central banks and financial market regulators to enhance anti-corruption practices within the financial institutions to increase transparency and enhance their performance.

Originality/value
Fighting against anti-corruption is essential for financial institutions. This paper is the first study that examined the extent of anti-corruption levels and their effect on banking performance for both Islamic and conventional banks operates in the UAE. The findings help in enhancing reporting practices in terms of anti-corruption to improve transparency and performance in the banking sector.
Money laundering in selected emerging economies: is there a role for banks?
Authors: Alnasser Mohammed Sulaiman Abdullah Saif 
Published: June 2020

Purpose
Understanding money laundering plays an important role in understanding economic growth (EG). Extensive research is conducted about that, previous research lacks answers about the relationship of anti-money laundering (AML) and EG by investigating the roles of the performance of Islamic banks, legal environment, financial crisis (FC) and bank size. Therefore, the purpose of this paper is to cover that gap.

Design/methodology/approach
SmartPLS 3.0 was used and 33 Islamic banks were selected from developing countries between 2007 and 2010.

Findings
Note that AML, Islamic bank performance, legal environment, and FC are significantly related to EG.

Research limitations/implications
The research would be of importance to those seeking to understand the determinants of EG; it is also beneficial for those writing books about money laundering and Islamic banks in developing countries. The limitation of the study is the low number of Islamic banks that have complete data. Thus, this could be future research contribution.

Originality/value
To the best knowledge of the author, research on money laundering and Islamic banks in developing countries are not extensive, we have found an ample room to discuss the said variables.
Measuring happiness at work in a Takaful organization
Authors: Mroueh Meerna , de Waal André 
Published: June 2020

PurposeHappiness at work (HAW) has been a hot item in both the academic and managerial literature, as HAW seems to have a positive effect on attractiveness of an organization on its current workforce and potential new employees. Many of the HAW models have been developed in a Western setting, while this research aims at evaluation of whether a previously validated HAW model in the Western context is also valid in a non-Western context; in this case at a Takaful insurance company in the United Arab Emirates.Design/methodology/approachEmployees of the Takaful insurance company were asked to rate their organization on how high performance it was – using the validated high-performance organization (HPO) questionnaire – and how happy they were – using the previously validated HAW questionnaire. The collected data was subjected to confirmatory factor analyses and structural equation modeling to arrive at a validated HAW model for this Takaful insurance company.FindingsThe study results show that if the Takaful insurance company transforms itself to an HPO, it will become more attractive to current and future employees, by raising the HAW of current employees. The results also show that HAW consists of three factors: work engagement, job satisfaction and affective organizational commitment.Practical implicationsThe Takaful insurance company now has knowledge at its disposal about ways to promote happiness in its employees, thus raising its attractiveness to current and future employees. The developed HAW model for this company is potentially also useful for other Takaful insurance companies in the UAE.Originality/valueThis study was the first of its kind – using the HPO and HAW models developed in a Western context, to be validated for a Takaful insurance company – and as such, contributes to both the HPO and HAW literature.
Sustainability of supply chains in the wake of the coronavirus (COVID-19/SARS-CoV-2) pandemic: lessons and trends
Authors: Lopes de Sousa Jabbour Ana Beatriz , Chiappetta Jabbour Charbel Jose , Hingley Martin , Vilalta-Perdomo Eliseo Luis , Ramsden Gary , Twigg David 
Published: June 2020

PurposeThe purpose of this article is to address the prioritisation and focus of supply chain managers subsequent to coronavirus disease 2019 (COVID-19)/severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the great lockdown of 2020.Design/methodology/approachIn this article, concepts and trends on resilient and sustainable supply chains are systematized. Main trends in sustainability of supply chains in the wake of COVID-19 are presented.FindingsGuidelines on building smarter and more resilient supply chains are provided and future tendencies, which includes the increase of a sustainable consumption perspective, are highlighted.Originality/valueThis is a conceptual article blended with a practical approach aiming to propose guidelines for managers and scholars on how to address supply chain management challenges after the coronavirus pandemic.
Industry 4.0 deployment in the construction industry: a bibliometric literature review and UK-based case study
Authors: Newman Chris , Edwards David , Martek Igor , Lai Joseph , Thwala Wellington Didibhuku , Rillie Iain 
Published: June 2020

PurposeIndustry 4.0 is predicted to be a game-changer, revolutionizing commercial and manufacturing practices through improved knowledge utilization and efficiencies. The barriers however, are significant, and the construction industry remains notoriously slow to take up innovations. This study reviews the research work in Industry 4.0 as it relates to construction, and examines a leading UK-based construction firm to ascertain the prognosis for Industry 4.0 roll-out in terms of the impediments and opportunities.Design/methodology/approachA multistage mixed philosophies and methods approach was adopted for this study. First, an interpretivist epistemological lens was used to synthesise extant literature as a means of contextualizing the present study. Second, an empirical case study using a post-positivist stance and inductive reasoning was conducted to explore practitioner acceptance of Industry 4.0 in the UK construction context.FindingsFindings from the literature review indicate studies in Industry 4.0 to be a relatively new phenomenon, with developed countries and Germany in particular leading in the field. The range of opportunities are many, but so too are the barriers to enablement. Findings from the case study provide real-world corroboration of the review; practitioners are sanguine about Industry 4.0's potential to reinvigorate the construction industry, but also note that implementation remains curtailed by residual managerial practices dependent on ‘human interaction’. At present, much of the focus of industry practitioners is on the implementation of building information modelling (BIM), often at the expense of other more advanced technologies within Industry 4.0.Originality/valueResearch in Industry 4.0 is limited, with the emphasis being on technology application. This paper, by contrast, maps the totality of work carried out so far and presents an assessment of Industry 4.0's progression, potential and degree of uptake within the UK construction industry.
The learning company: the learning organization the British way – its origins, present, and future directions. An interview with John Burgoyne
Authors: Bogolyubov Pavel 
Published: June 2020

Purpose
This paper aims to provide an overview of the history, the present and the future or the learning organization as a concept and a practical approach, from the perspective of Professor John Burgoyne.

Design/methodology/approach
This conversation piece follows the development of the concept from its early days into the current debates and the possible directions for future development.

Findings
The interview highlights an interesting path the learning organization took in the UK, stemming from a drive for more and better management education, and evolving into a systemic view on various aspects of organizational capabilities, concerned primarily with organizational longevity and adaptability. The thinking behind Pedler, Burgoyne and Boydell’s model of a learning company is discussed. Several “hot” topics are identified, either overlooked in the past, or becoming more relevant in the modern world, precipitated by technological and societal changes.

Originality/value
The interview provides an insight into the thinking of one of the best known authors in the field. Understanding of the concept’s evolution path, as well as the influences from other fields such as innovation and CSR, could be useful for practitioners and academics working in the subject area, wishing to identify promising future directions for research and practice.
Spatial–temporal dynamics of rainfall erosivity in the state of Espírito Santo (Brazil) from remote sensing data
Authors: Moreira Luana Lavagnoli , Novais Rafael Rezende , Schwamback Dimaghi , Carvalho Júnior Salomão Martins de 
Published: June 2020

PurposeThe most common methodology to estimate erosivity is using rainfall data obtained from rain monitoring stations. However, the quality of this estimation may be compromised due to low density, operational problems and maintenance cost of rainfall monitoring stations, common problem encountered in developing countries such as Brazil. The objective of this study was to evaluate the applicability of pluviometric data obtained by TRMM satellite images for the spatiotemporal characterization of erosivity in the state of Espírito Santo (Brazil).Design/methodology/approachFor this, rainfall data and annual and monthly erosivities of 71 rainfall stations were statistically compared with those from TRMM images.FindingsFor this, rainfall data and annual and monthly erosivities of 71 rainfall stations were statistically compared with those from TRMM images. The estimate proved that TRMM is efficient since the NSE values were higher than 0.70 and the coefficient of determination was higher than 0.77 for monthly and annual erosivities, but in most months and yearly, erosivity was overestimated.Practical implicationsThe use of satellite images to estimate rainfall allowed the spatial representation over time (months) of the oscillating degree of erosivity in the state of Espírito Santo (Brazil). The spatialization may provide an identification of areas and periods in which are essential for the implementation of land use management in order to minimize environmental problems related to soil loss.Originality/valueThe technique applied may be an alternative to overcome common problems on rainfall monitoring station, such as low density, low data reliability, high manutention and maintenance cost and operational problems.