bluuebunny/crossref_metadata_2025_split huggingface dataset:
Instagram: A platform for ultrasound education?
Authors: Alsafi Nour , Alsafi Ali 
Published: April 2020

Introduction Social media has become an integral part of our daily life with 38 million users in the UK alone and the average user being logged-in for 135 minutes daily. Social media is increasingly used to disseminate learning in a variety of fields including medicine. Objectives The aim of this study was to assess the proportion of Instagram posts using #ultrasound for educational content and compare this with #radiology. We also aimed to assess the changes in the use of the newly introduced #UltrasoundEd for ultrasound education since its introduction in November 2018. Methods Instagram searches were conducted using the hashtags: #ultrasound and #radiology, and the content of the first 100 posts from each search was analysed and classified into being either social or educational. A second search using #UltrasoundEd was conducted at baseline, 3 months and 12 months. Fisher’s exact test was used to compare categorical data. Results The searches retrieved 461,884 #ultrasound and 243,011 #radiology posts. From the first 100 #ultrasound posts, 11 were educational and 89 were social. The social posts predominantly related to announcements of pregnancy. Of the 100 #radiology posts, 49 were educational, while 51 were classified as social. The number of posts with the hashtag #UltrasoundEd increased over the study period from 15 to 232, with the majority of posts being educational. Conclusions Educational ultrasound content is difficult to separate from social posts on Instagram. The use of the hashtag #UltrasoundEd makes educational ultrasound content more readily identifiable.
Rapid diffusion-weighted MRI for the investigation of recurrent temporal bone cholesteatoma
Authors: Kavanagh Richard G , Liddy Stephen , Carroll Anne G , Purcell Yvonne M , Smyth Anna E , Khoo S Guan , McNeill Graeme , Malone Dermot E , Killeen Ronan P 
Published: April 2020

Background Suspected cholesteatoma recurrence is commonly investigated with magnetic resonance imaging (MRI) of the temporal bone. Non-echo planar diffusion-weighted imaging (non-EP DWI) has become the sequence of choice. Purpose To assess the agreement between an MRI protocol incorporating both non-EP DWI and contrast-enhanced sequences, and a shortened protocol without contrast-enhanced sequences in the assessment of suspected cholesteatoma recurrence. Materials and methods One hundred consecutive MRIs, consisting of T2-weighted, non-EP DWI and pre- and post-contrast T1-weighted sequences, were reviewed by two radiologists at a tertiary referral centre. Agreement between the two protocols was assessment by means of a weighted Cohen kappa coefficient. Results We found a near perfect agreement between the two protocols (kappa coefficient with linear weighting 0.98; 95% confidence interval 0.95–1.00). There were two cases in which the two protocols were discordant. In both cases, the lesion measured <3 mm and images were degraded by artefact at the bone–air interface. The shortened protocol without post-contrast sequences yielded a 32% reduction in acquisition time. Conclusion When non-EP DWI is available, contrast-enhanced sequences can be omitted in the vast majority of cases without compromising diagnostic accuracy. Contrast-enhanced sequences may provide additional value in equivocal cases with small (<3 mm) lesions or in cases where images are degraded by artefact.
Transabdominal ultrasonography: A non-invasive method for diagnosing vaginal atrophy
Authors: Kanmaz Ahkam Göksel , İnan Abdurrahman Hamdi , Beyan Emrah , Budak Adnan , Töz Emrah , Alan Murat , Özeren Mehmet 
Published: April 2020

Objective Genitourinary syndrome of menopause is a definition of all symptoms caused by hypoestrogenemia in menopausal age and one of the most common symptoms is vaginal atrophy. The diagnosis methods which are used for vaginal atrophy may be painful. A novel method total vaginal thickness and total mucosal thickness measuring could be determine vaginal atrophy. Material and methods This is a prospective case–control study involving 60 women in each group of 120 patients. One of the groups is comprised postmenopausal, histopathologically diagnosed vaginal atrophic women and the other group comprised 24–35 aged women who were no symptoms of vaginal atrophy and vaginal swab samples are not compatible with vaginal atrophy. All women who participated in the study underwent transabdominal ultrasound and total vaginal thickness and total mucosal thickness were measured. Results Total vaginal thickness and total mucosal thickness were found lower in the postmenopausal group compared to premenopausal women ( p = 0.005 and p = 0.07, respectively). The cutoff value was determined as 8.55 mm for total vaginal thickness and 1.52 mm for total mucosal thickness, and the diagnostic power of these values is a specificity of 88.89% (95% confidence interval: 51.75–99.72%) and a ppv of 92.86% (95% confidence interval: 66.53–98.84%) for total vaginal thickness and a specificity of 80.95% (95% confidence interval: 58.09–94.55%) and a ppv of 89.47% (95% confidence interval: 71.10–96.71%) for total mucosal thickness. Conclusion Vaginal atrophy is a painful symptom for menopausal women and the diagnostic methods may be invasive and painful too. Total vaginal thickness and total mucosal thickness measuring with transabdominal ultrasound could be an alternative method for diagnosis and treat vaginal atrophy easily.
The accuracy of different FRAX tools in predicting fracture risk in Japan: A comparison study.
Authors: Xu Gang , Yamamoto Norio , Hayashi Katsuhiro , Takeuchi Akihiko , Miwa Shinji , Igarashi Kentaro , Taniguchi Yuta , Araki Yoshihiro , Yonezawa Hirotaka , Morinaga Sei , Tsuchiya Hiroyuki 
Published: April 2020

Introduction: The web version of Fracture Risk Assessment (FRAX) tool is widely used in many countries to predict the 10-year probability of major osteoporotic fracture (MF) and hip fracture (HF) rate. However, other FRAX tools, calculator older version (first generation), calculator new version (second generation), and application of mobile software had also been used in Japan. Purpose: The aim of this study is to investigate the consistency of results obtained from the four predicting tools for MF and HF rate in both male and female groups. Methods: The data were extracted from 2016 medical examination report of Japanese Ministry of Health of Labor and Welfare. The MF and HF rates were calculated from 40 to 90 years old under different risk factors using four FRAX tools while the consistency of predicting value was evaluated. Results: The predicted MF or HF rates were extremely similar among calculator new version, mobile software, and website version in each risk factors. On other hand, for calculator older version, the predicted MF or HF rates are a little higher than other versions. The significant difference is only present in patients aged 75 and above, and this exceeds the FRAX threshold older than 75 years old by Japanese Society for Bone and Mineral Research. Conclusions: The application of four FRAX tools generated consistent results in predicting the 10-year probability of major osteoporotic fracture and HF for clinical practice, which provides an effective evidence for clinical application.
Simple Linear Calculating Method of Glenoid Bone Defects Using 3-Dimensional Computed Tomography Based on an East Asian Population in China
Authors: Chen Xing-zuo , Liu Tong-xi , Chen Ying , Du Lei , Liu Wei-fang , Lin Peng 
Published: April 2020

Background: The evaluation of glenoid bone defects in the preoperative stage for patients with anterior shoulder instability is critical for surgical decision making. A novel method that predicts the intact glenoid width based purely on the measurement of the glenoid height has been advocated. Despite the convenience, all studies to date have focused on the Western population, and there is no similar research based on an East Asian population. Purpose: To determine the relationship between glenoid height and width in an East Asian population. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Spiral computed tomography (CT) scans of both sides of the shoulder joints were obtained from 205 patients of Han nationality (China) who had no history of shoulder trauma or pain. The maximal height and width of each glenoid were measured on the en face view by 2 radiologists who were blinded to each other’s results. Pearson correlation coefficients and multivariable linear regression were calculated from all data measured to evaluate the relationship between maximal glenoid height and width between the sexes. Results: A total of 205 patients (410 shoulder CT scans) were analyzed. The mean glenoid height was 34.45 ± 2.82 mm, and the mean glenoid width was 23.35 ± 2.40 mm. There was a statistical difference between male and female patients with regard to glenoid height (36.61 vs 32.39 mm, respectively; t = 9.76; P < .001) and width (25.26 vs 21.54 mm, respectively; t = 20.73; P < .001). Analysis of the measured glenoid height and width demonstrated a strong linear correlation of 0.82 ( R 2 = 0.68; P < .001) for the entire cohort and similarly strong linear correlations when each sex was analyzed separately. For male patients, the glenoid width was measured as: glenoid height × 0.50 + 7 mm ( R 2 = 0.36; P < .001); for female patients, the glenoid width was measured as: glenoid height × 0.45 + 7 mm ( R 2 = 0.31; P < .001). Conclusion: In an East Asian population, the mean glenoid height and width were 34.45 and 23.35 mm, respectively. The formulas that represent the relationship between glenoid width and height for male and female patients are the following: glenoid width = glenoid height × 0.50 + 7 mm and glenoid width = glenoid height × 0.45 + 7 mm, respectively.
Optimizing the Double-Row Construct: An Untied Medial Row Demonstrates Equivalent Mean Contact Pressures in a Rotator Cuff Model
Authors: Stone Austin V. , Luo T. David , Sharma Aman , Danelson Kerry A. , De Gregorio Michael , Freehill Michael T. 
Published: April 2020

Background: The merits of a double-row rotator cuff repair (RCR) construct are well-established for restoration of the footprint and lateral-row security. The theoretical benefit of leaving the medial row untied is to prevent damage to the rotator cuff by tissue strangulation, and the benefit of suture tape is a more even distribution of force across the repair site. These benefits, to our knowledge, have not been evaluated in the laboratory. Hypothesis: Leaving the medial row untied and using a suture bridge technique with suture tape will offer more even pressure distribution across the repair site without compromising total contact force. Study Design: Controlled laboratory study. Methods: A laboratory model of RCR was created using biomechanical research-grade composite humeri and human dermal allografts. The pressure distribution in a double-row suture bridge repair construct was analyzed using the following testing matrix: double-loaded suture anchors with the medial row tied (n = 15) versus untied (n = 15) compared with double-loaded suture tape and anchors with the medial row tied (n = 15) versus untied (n = 15). A digital pressure sensor was used to measure pressure over time after tensioning of the repair site. A multivariate analysis of variance was used for statistical analysis with post hoc testing. Results: The total contact force did not significantly differ between constructs. The contact force between double-loaded suture anchors and double-loaded suture tape and anchors was similar when tied ( P = .15) and untied ( P = .44). An untied medial row resulted in similar contact forces in both the double-loaded suture anchor ( P = .16) and double-loaded suture tape and anchor ( P = .25) constructs. Qualitative increases in focal contact pressure were seen when the medial row was tied. Conclusion: An untied medial row did not significantly affect the total contact force with double-loaded suture anchors and with double-loaded suture tape and anchors. Tying the medial row qualitatively increased crimping at the construct’s periphery, which may contribute to tissue strangulation and hinder clinical healing. Qualitative improvements in force distribution were seen with double-loaded suture tape and anchors. Clinical Relevance: Both tied and untied medial rows demonstrated similar pressures across the repair construct.
RETRACTED ARTICLE: High failure rate after Beta-tricalcium phosphate grafting for the treatment of femoral head osteonecrosis: a retrospective analysis
Authors: Liu Pei , Mu Xiao-hong , Yu Hua-chen , Guan Jian-lei , Liu Zhao-hui , Wang Wei-guo , Zhang Qi-dong , Guo Wan-shou 
Published: April 2020

AbstractBackgroundNon-vascularized bone grafting is a promising head-preserving technique for younger patients diagnosed as non-traumatic osteonecrosis of the femoral head (NONFH). Among the various types of bone grafting techniques, “light-bulb” procedure grafting with synthetic bone substitute is an attractive option. We aimed to assess the effectiveness of using beta-tricalcium phosphate (β-TCP) for the treatment of pre-collapse and early post-collapse lesions NONFH.MethodsFrom April 2010 to June 2014, 33 patients (47 hips) with NONFH were treated using the afore-mentioned technique. The clinical and radiological outcomes were recorded and compared statistically between pre- and post-operation. Harris hip score (HHS) was used to evaluate the clinical results, and Association Research Circulation Osseous (ARCO) stage was applied to assess the radiological outcomes.ResultsThe 5-years survival rate of using β-TCP grafting was accounting for 25.5%. HHS was decreased from 78.47 to 52.87 points, and a very significant worsening of radiological results were revealed (P <  0.05). Two hips collapsed more than 2 mm were awaiting for THA, and 33 of the 47 hips had converted to THAs in an average time to failure of 24.24 months postoperatively. Meanwhile, only 4 hips survived without collapse, and 8 hips collapsed less than 2 mm. After surgery, the time onset of head collapse was 3.65 months on average, and the first conversion to THA was performed at 5 months postoperative.ConclusionsOur results suggest that “light-bulb” procedure grafting with β-TCP sticks presented with a high failure rate in the early postoperative period. It is not proposed for the treatment of pre-collapse and early post-collapse lesions NONFH.
No functional differences in anatomic reconstruction with one vs. two suture anchors after non-simultaneous bilateral distal biceps brachii tendon rupture: a case report and review of the literature
Authors: Weißenberger Manuel , Heinz Tizian , Rueckl Kilian , Rudert Maximilian , Klug Alexander , Hoffmann Reinhard , Schmidt-Horlohé Kay 
Published: April 2020

Abstract
Background
Surgical reattachment of the tendon is still the gold standard for ruptures of the distal biceps brachii tendon. Several fixation techniques have been described in the literature, with suture anchors being one of the most common fixation techniques. Currently, there is no data available on how many anchors are required for a safe and stable refixation. In this case report clinical data of a patient with non-simultaneous bilateral distal biceps tendon ruptures treated with a different number of suture anchors for each side (one vs. two) are demonstrated.

Case presentation
A 47-year-old factory worker suffered a rupture of the distal biceps tendon on both arms following two different occasions. The left side was fixed using a single suture anchor, while refixation on the right side was performed with two anchors.
The patient was prospectively followed for one year. Functional outcome was assessed using the Andrews Carson Score (ACS), the Oxford Elbow Score (OES), and the Disabilities of Arm, Shoulder and Hand (DASH) Score after six, twelve, 24 and 48 weeks. Furthermore, an isokinetic strength measurement for flexion strength was performed after 24 and 48 weeks.
After 48 weeks the patient presented with excellent functional outcome scores and no follow-up complications. During the follow-up period, no differences in the functional scores nor in the isokinetic flexion strength measurement could be detected. Furthermore, no radiological complications (like heterotopic ossifications) could be detected in the postoperative radiographs after one year.

Conclusions
Anatomic reattachment of the distal biceps tendon is a successful operative treatment option for distal biceps tendon ruptures. Suture anchor fixation remains one of the most common techniques, as it allows fast surgery and provides good results with respect to range of motion (ROM) and functional scoring according to the current literature. However, the number of anchors required for a stable fixation remains unclear. As indicated by our presented case, we hypothesize, that there are no significant differences between a one-point or a two-point fixation. In the presented case report, no intraindividual differences between the usage of one versus two suture anchors were evident in the short-term follow-up.
Hydroalcoholic extract of Achillea millefolium improved blood glucose, liver enzymes and lipid profile compared to metformin in streptozotocin-induced diabetic rats
Authors: Rezaei Shahla , Ashkar Fatemeh , Koohpeyma Farhad , Mahmoodi Marzieh , Gholamalizadeh Maryam , Mazloom Zohreh , Doaei Saeid 
Published: April 2020

Abstract
Background
Recent studies have reported that herbal extracts may have some protective effect against the complications of diabetes mellitus. This study aimed to investigate the effects of Achillea millefolium hydroalcoholic extract in comparison to metformin on liver damage, lipid abnormality, and glycemic control in diabetic rats.

Methods
Rats were randomly assigned to 7 groups of 10 animals. Diabetes was induced by injection of streptozotocin (STZ) to 4 groups of rats. Three groups of diabetic rats were given 250 mg/kg/day metformin, 25 mg/kg/day Achillea millefolium hydroalcoholic extract, or 100 mg/kg/day of this extract. Two non-diabetic groups were also given either 25 mg/kg/day or 100 mg/kg/day Achillea millefolium extract. Normal control and diabetic control rats received 1 mL/day of normal saline. Treatments were administered through oral gavage for 28 days. At the end, rats were anesthetized with ether and their serum samples were separated in order to measure blood glucose, serum total protein, lipids, and liver enzymes.

Results
There was a significant reduction in blood glucose, serum liver enzymes, triglycerides, and total- and LDL-cholesterol levels of the Achillea millefolium extract-treated groups compared to the other groups. In addition, there was a significant increment in body weight and HDL-cholesterol serum level in the Achillea millefolium-treated groups.

Conclusion
Achillea millefolium extract compared to metformin reduces lipid abnormality, blood glucose and liver enzymes in STZ-induced diabetic rats. Future clinical studies are warranted to confirm our experimental findings in humans.
Imaging biomarkers in neurodegeneration: current and future practices
Authors: Young Peter N. E. , Estarellas Mar , Coomans Emma , Srikrishna Meera , Beaumont Helen , Maass Anne , Venkataraman Ashwin V. , Lissaman Rikki , Jiménez Daniel , Betts Matthew J. , McGlinchey Eimear , Berron David , O’Connor Antoinette , Fox Nick C. , Pereira Joana B. , Jagust William , Carter Stephen F. , Paterson Ross W. , Schöll Michael 
Published: April 2020

AbstractThere is an increasing role for biological markers (biomarkers) in the understanding and diagnosis of neurodegenerative disorders. The application of imaging biomarkers specifically for the in vivo investigation of neurodegenerative disorders has increased substantially over the past decades and continues to provide further benefits both to the diagnosis and understanding of these diseases. This review forms part of a series of articles which stem from the University College London/University of Gothenburg course “Biomarkers in neurodegenerative diseases”. In this review, we focus on neuroimaging, specifically positron emission tomography (PET) and magnetic resonance imaging (MRI), giving an overview of the current established practices clinically and in research as well as new techniques being developed. We will also discuss the use of machine learning (ML) techniques within these fields to provide additional insights to early diagnosis and multimodal analysis.
Identification of key genes and pathways in syphilis combined with diabetes: a bioinformatics study
Authors: Li Wei , Luo Chunyi , Xie Xiaoping , Xiao Yongjian , Zhao Feijun , Cai Jialun , Zhou Xiangping , Zeng Tiebing , Fu Bo , Wu Yimou , Xiao Xinhua , Liu Shuangquan 
Published: April 2020

AbstractWe noticed that syphilis patients seem to be more susceptible to diabetes and the lesions often involve the kidneys, but the pathogenesis is not yet completely understood. In this study, microarray analysis was performed to investigate the dysregulated expressed genes (DEGs) in rabbit model of syphilis combined with diabetes. A total of 1045 genes were identified to be significantly differentially expressed, among which 571 were up-regulated and 474 were down-regulated (≥ 2.0fold, p < 0.05). Using the database visualization and integration discovery for the Kyoto Encyclopedia of Gene and Genome (KEGG) pathway enrichment analysis. The downregulated DEGs were significantly enriched for biosynthesis of antibiotics, carbon metabolism and protein digestion, while the upregulated DEGs were mainly enriched for cancer and PI3K-Akt signaling pathway. Molecular Complex Detection (MCODE) plugins were used to visualize protein–protein interaction (PPI) network of DEGs and Screening for hub genes and gene modules. ALB, FN1, CASP3, MMP9, IL8, CTGF, STAT3, IGF1, VCAM-1 and HGF were filtrated as the hub genes according to the degree of connectivity from the PPI network. To the best of our knowledge, this study is the first to comprehensively identify the expression patterns of dysregulated genes in syphilis combined with diabetes, providing a basis for revealing the underlying pathogenesis of syphilis combined with diabetes and exploring the goals of therapeutic intervention.
A hybrid SWOT analysis of the neuromodulation process for chronic pain
Authors: Puurunen Anne , Ikäheimo Tiina-Mari , Nissen Mette , Huotarinen Antti , Jyrkkänen Henna-Kaisa , Huttunen Jukka , Koivisto Timo , von und zu Fraunberg Mikael , Kajanus Miika 
Published: April 2020

Background: Spinal cord stimulation is an efficient treatment for selected patients with chronic neuropathic pain. Since 2015, neuromodulation nurses at Kuopio University Hospital have been responsible for patient education and stimulator adjustments. Aims: The purpose is to determine what factors professionals perceived to affect patients' wellbeing in the neuromodulation process for chronic neuropathic pain. Methods: Four nurses and four physicians on the neuromodulation team performed a strengths, weaknesses, opportunities and threats analysis of the operational environment. All evaluated the attributes independently, and a multiple-criteria analysis was performed based on the results. Findings: The most important factors were excellent or good treatment results, having neuromodulation nurses, having a well-functioning neuromodulation team, vulnerability because of the limited number of specialists, and the establishment of a pain centre. Conclusion: This study highlights the importance of neuromodulation nurses and teamwork in chronic pain neuromodulation. The establishment of a multidisciplinary pain centre is strongly recommended.