bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does tricuspid valve detachment improve outcomes compared with the non-tricuspid valve detachment approach in ventricular septal defect closure?
Authors: Ling Yunfei , Bian Xiaohui , Wang Yue , Qian Yongjun 
Published: December 2020

Summary
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether the tricuspid valve detachment (TVD) approach to ventricular septal defect repair provides superior outcomes compared with the non-TVD approach. Altogether more than 54 papers were found using the reported search, of which 10 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. A total of 2059 participants were enrolled in the 10 studies, including 2 prospective studies and 8 retrospective studies. Six studies demonstrated a longer cardiopulmonary bypass time or aortic clamp time in the TVD group, whereas 4 studies showed no difference. Only 1 study reported a lower incidence of trivial tricuspid regurgitation in the TVD group, whereas the other 9 studies showed no significant difference. One study showed that a higher incidence of residual shunting occurred in those patients who had indications for TVD but did not perform detachment during surgery. No difference in postoperative residual shunting was demonstrated in the other 9 studies. We conclude that surgeons should be reassured that if TVD is required to repair the ventricular septal defect, although it may lead to longer cardiopulmonary bypass time and cross-clamp times, outcomes are equivalent in terms of the degree of tricuspid regurgitation and incidence of the residual ventricular septal defect.
Clinical Switching Strategies of Various Antidepressants to Vortioxetine in the PREDDICT Trial
Authors: Mills Natalie T , Sampson Emma , Fourrier Célia , Baune Bernhard T 
Published: December 2020

Abstract

Background
Partial response to antidepressant medication as well as relapse and treatment resistance are common in major depressive disorder (MDD). Therefore, for most patients with MDD, there will be a need to consider changing antidepressant medication at some stage during the course of the illness. The PREDDICT study investigates the efficacy of augmenting vortioxetine with celecoxib.

Methods
We describe the method used in the PREDDICT study to change participants, who were already taking antidepressant medication at the time of the screening visit, to vortioxetine. We used a cross-titration to change study participants to vortioxetine.

Results
Of a total of 122 study participants who were randomized to receive vortioxetine plus celecoxib or vortioxetine plus placebo at the study baseline visit, 82 were taking antidepressant medication (other than vortioxetine) prior to randomization. These medications were selective serotonin reuptake inhibitors, serotonin noradrenaline reuptake inhibitors, tricyclic antidepressants, mirtazapine, or agomelatine. Eighty of these 82 participants completed the changeover to vortioxetine as well as the study baseline visit. We found side effects were generally mild during this changeover period. In addition, there was a reduction in mean total Montgomery-Åsberg Depression Rating Scale score of 2.5 (SD 6.0) from study baseline to week 2 and a further reduction in mean total Montgomery-Åsberg Depression Rating Scale of 2.5 (SD 5.9) from week 2 to week 4.

Conclusion
Changing other antidepressants to vortioxetine can be done safely and was generally well-tolerated. However, there are some antidepressant classes, in particular monoamine oxidase inhibitors that require a washout period, which were not represented in this study.

Trial registration
Australian New Zealand Clinical Trials Registry (ANZCTR); ID number 12617000527369p; http://www.anzctr.org.au/ACTRN12617000527369p.aspx
Effectiveness of Palivizumab Against Respiratory Syncytial Virus Hospitalization Among Preterm Infants in a Setting With Year-Round Circulation
Authors: Yeo Kee Thai , Yung Chee Fu , Khoo Poh Choo , Saffari Seyed Ehsan , Sng Jane Swee Peng , How Mee See , Quek Bin Huey 
Published: December 2020

Abstract

Background
The year-round respiratory syncytial virus (RSV) circulation in tropical regions leads to different transmission patterns and burden of disease among infants born very preterm.

Methods
We conducted a retrospective cohort study to estimate the effectiveness of palivizumab in preventing RSV hospitalization at 6 and 12 months after discharge, among infants born at &lt;32 weeks’ gestation in our tropical setting.

Results
A total of 109 infants (26.3%) received palivizumab at discharge, of 415 who were eligible. All patients received ≥4 doses, with 105 infants (96.3%) completing 5 doses. Within 1 year after discharge, there were 35 RSV-associated admissions (3 [2.8%] in the palivizumab vs 32 [10.5%] in the nonpalivizumab group; P = .02). After adjustment for confounders, the effectiveness of palivizumab against RSV hospitalization was estimated to be 90% (95% confidence interval, 10%–99%) up to 6 months after discharge. The median time to RSV hospitalization was shorter in the nonpalivizumab than in the palivizumab group (median [range], 155 [15–358] vs 287 [145–359] days, respectively; P = .11). Five infants (14.3%), all from the nonpalivizumab group, required admission to the intensive care unit.

Conclusions
In our setting with year-round RSV circulation, palivizumab prophylaxis was effective in reducing RSV hospitalization among high-risk preterm infants of &lt;32 weeks’ gestation within the initial 6 months after discharge.
Evaluation of electronic health record-integrated digital health tools to engage hospitalized patients in discharge preparation
Authors: Dalal Anuj K , Piniella Nicholas , Fuller Theresa E , Pong Denise , Pardo Michael , Bessa Nathaniel , Yoon Catherine , Lipsitz Stuart , Schnipper Jeffrey L 
Published: December 2020

Abstract

Objective
To evaluate the effect of electronic health record (EHR)-integrated digital health tools comprised of a checklist and video on transitions-of-care outcomes for patients preparing for discharge.

Materials and Methods
English-speaking, general medicine patients (&gt;18 years) hospitalized at least 24 hours at an academic medical center in Boston, MA were enrolled before and after implementation. A structured checklist and video were administered on a mobile device via a patient portal or web-based survey at least 24 hours prior to anticipated discharge. Checklist responses were available for clinicians to review in real time via an EHR-integrated safety dashboard. The primary outcome was patient activation at discharge assessed by patient activation (PAM)-13. Secondary outcomes included postdischarge patient activation, hospital operational metrics, healthcare resource utilization assessed by 30-day follow-up calls and administrative data and change in patient activation from discharge to 30 days postdischarge.

Results
Of 673 patients approached, 484 (71.9%) enrolled. The proportion of activated patients (PAM level 3 or 4) at discharge was nonsignificantly higher for the 234 postimplementation compared with the 245 preimplementation participants (59.8% vs 56.7%, adjusted OR 1.23 [0.38, 3.96], P = .73). Postimplementation participants reported 3.75 (3.02) concerns via the checklist. Mean length of stay was significantly higher for postimplementation compared with preimplementation participants (10.13 vs 6.21, P &lt; .01). While there was no effect on postdischarge outcomes, there was a nonsignificant decrease in change in patient activation within participants from pre- to postimplementation (adjusted difference-in-difference of −16.1% (9.6), P = .09).

Conclusions
EHR-integrated digital health tools to prepare patients for discharge did not significantly increase patient activation and was associated with a longer length of stay. While issues uncovered by the checklist may have encouraged patients to inquire about their discharge preparedness, other factors associated with patient activation and length of stay may explain our observations. We offer insights for using PAM-13 in context of real-world health-IT implementations.

Trial Registration
NIH US National Library of Medicine, NCT03116074, clinicaltrials.gov
Ziada v. Gantz and Eshel
Authors: Clark Kate 
Published: December 2020

Abstract
Civilians who bring claims against powerful states or their officials, for harm resulting from the conduct of war, face challenges that no single legal procedure can possibly overcome. Certain codified international laws outline specific protections for civilians, but this protective infrastructure stands in the shadow of two creatures of uncodified international customary law: state sovereignty and the immunity of states and their officials. The subject of this case note is a civil claim before a Dutch domestic court, against powerful officials of the state of Israel. The claimant, a Palestinian Dutch national, is attempting to sue the officials for the unlawful killing of six members of his family in the intentional bombing of their home in Gaza in 2014. In January 2020, he set out to establish the Dutch court’s jurisdiction based on an exceptional provision of the Dutch Code of Civil Procedure. This contribution argues that the Dutch court erred in allowing the asserted ‘functional immunity’ of the foreign officials to counter its own jurisdiction.
Dual Nationality and International Criminal Court Jurisdiction
Authors: Wolman Andrew 
Published: December 2020

Abstract
The International Criminal Court (ICC) can exercise jurisdiction over nationals of states parties. However, it has never been clear whether the Court will automatically recognize a nationality that has been conferred by a state party under its domestic law, nor what criteria it would use to evaluate that nationality should it not be automatically accepted. In December 2019, the Office of the Prosecutor made its first formal pronouncement on the question, finding that the ICC does not have jurisdiction over North Koreans, despite their being South Korean nationals under South Korean law, because North Koreans are not able to exercise their rights as South Koreans until accepted as such by application, and on occasion their applications might be refused. In this article, I reject the Prosecutor’s analysis as misguided. I also reject the other main approaches to nationality recognition suggested by scholars, namely a ‘genuine link’ requirement, a deferral to municipal law, and a deferral to municipal law except where a conferral of nationality violates international law. Instead, I propose a functional approach that would respect municipal conferral of nationality unless that conferral unreasonably interferes with the sovereign interests of a non-state party.
A Prospective Evaluation of Xpert MTB/RIF Ultra for Childhood Pulmonary Tuberculosis in Uganda
Authors: Jaganath Devan , Wambi Peter , Reza Tania F , Nakafeero Jascent , Aben Ernest O , Kiconco Emma , Nannyonga Gertrude , Nsereko Moses , Sekadde Moorine P , Mudiope Mary , Kato-Maeda Midori , Starke Jeffrey , Andama Alfred , Mohanty Swomitra , Wobudeya Eric , Cattamanchi Adithya 
Published: December 2020

Abstract

Background
Xpert MTB/RIF Ultra (Xpert Ultra) has improved the sensitivity to detect pulmonary tuberculosis (TB) in adults. However, there have been limited prospective evaluations of its diagnostic accuracy in children.

Methods
We enrolled children undergoing assessment for pulmonary TB in Kampala, Uganda, over a 12-month period. Children received a complete TB evaluation and were classified as Confirmed, Unconfirmed, or Unlikely TB. We calculated the sensitivity and specificity of Xpert Ultra among children with Confirmed vs Unlikely TB. We also determined the diagnostic accuracy with clinical, microbiological, and extended microbiological reference standards (MRSs).

Results
Of the 213 children included, 23 (10.8%) had Confirmed TB, 88 (41.3%) had Unconfirmed TB, and 102 (47.9%) had Unlikely TB. The median age was 3.9 years, 13% were HIV-positive, and 61.5% were underweight. Xpert Ultra sensitivity was 69.6% (95% confidence interval [CI]: 47.1-86.8) among children with Confirmed TB and decreased to 23.4% (95% CI: 15.9-32.4) with the clinical reference standard. Specificity was 100% (95% CI: 96.4-100) among children with Unlikely TB and decreased to 94.7% (95% CI: 90.5-97.4) with a MRS. Sensitivity was 52.9% (95% CI: 35.1-70.2) and specificity 95.5% (95% CI: 91.4-98.1) with the extended MRS. Of the 26 positive Xpert Ultra results, 6 (23.1%) were “Trace-positive,” with most (5/6) occurring in children with Unconfirmed TB.

Conclusions
Xpert Ultra is a useful tool for diagnosing pulmonary TB in children, but there remains a need for more sensitive tests to detect culture-negative TB.
A machine-learning approach to correcting atmospheric seeing in solar flare observations
Authors: Armstrong John A , Fletcher Lyndsay 
Published: December 2020

ABSTRACT
Current post-processing techniques for the correction of atmospheric seeing in solar observations – such as Speckle interferometry and Phase Diversity methods – have limitations when it comes to their reconstructive capabilities of solar flare observations. This, combined with the sporadic nature of flares meaning observers cannot wait until seeing conditions are optimal before taking measurements, means that many ground-based solar flare observations are marred with bad seeing. To combat this, we propose a method for dedicated flare seeing correction based on training a deep neural network to learn to correct artificial seeing from flare observations taken during good seeing conditions. This model uses transfer learning, a novel technique in solar physics, to help learn these corrections. Transfer learning is when another network already trained on similar data is used to influence the learning of the new network. Once trained, the model has been applied to two flare data sets: one from AR12157 on 2014 September 6 and one from AR12673 on 2017 September 6. The results show good corrections to images with bad seeing with a relative error assigned to the estimate based on the performance of the model. Further discussion takes place of improvements to the robustness of the error on these estimates.
Exomoon candidates from transit timing variations: eight Kepler systems with TTVs explainable by photometrically unseen exomoons
Authors: Fox Chris , Wiegert Paul 
Published: December 2020

ABSTRACT
If a transiting exoplanet has a moon, that moon could be detected directly from the transit it produces itself, or indirectly via the transit timing variations (TTVs) it produces in its parent planet. There is a range of parameter space where the Kepler Space Telescope is sensitive to the TTVs exomoons might produce, though the moons themselves would be too small to detect photometrically via their own transits. The Earth’s Moon, for example, produces TTVs of 2.6 min amplitude by causing our planet to move around their mutual centre of mass. This is more than Kepler’s short-cadence interval of 1 min and so nominally detectable (if transit timings can be measured with comparable accuracy), even though the Moon’s transit signature is only 7 per cent that of Earth’s, well below Kepler’s nominal photometric threshold. Here, we examine several Kepler systems, exploring the hypothesis that an exomoon could be detected solely from the TTVs it induces on its host planet. We compare this with the alternate hypothesis that the TTVs are caused by an non-transiting planet in the system. We examine 13 Kepler systems and find 8 where both hypotheses explain the observed TTVs equally well. Though no definitive exomoon detection can be claimed on this basis, the observations are nevertheless completely consistent with a dynamically stable moon small enough to fall below Kepler’s photometric threshold for transit detection, and these systems warrant further observation and analysis.
Explicit symplectic-like integration with corrected map for inseparable Hamiltonian
Authors: Luo Junjie , Lin Weipeng , Yang Lili 
Published: December 2020

ABSTRACT
Symplectic algorithms are widely used for long-term integration of astrophysical problems. However, this technique can only be easily constructed for separable Hamiltonian, as preserving the phase-space structure. Recently, for inseparable Hamiltonian, the fourth-order extended phase-space explicit symplectic-like methods have been developed by using the Yoshida’s triple product with a mid-point map, where the algorithm is more effective, stable and also more accurate, compared with the sequent permutations of momenta and position coordinates, especially for some chaotic case. However, it has been found that, for the cases such as with chaotic orbits of spinning compact binary or circular restricted three-body system, it may cause secular drift in energy error and even more the computation break down. To solve this problem, we have made further improvement on the mid-point map with a momentum-scaling correction, which turns out to behave more stably in long-term evolution and have smaller energy error than previous methods. In particular, it could obtain a comparable phase-space distance as computing from the eighth-order Runge–Kutta method with the same time-step.
Cosmological constraints from higher redshift gamma-ray burst, H ii starburst galaxy, and quasar (and other) data
Authors: Cao Shulei , Ryan Joseph , Khadka Narayan , Ratra Bharat 
Published: December 2020

ABSTRACT
We use higher redshift gamma-ray burst (GRB), H ii starburst galaxy (H iiG), and quasar angular size (QSO-AS) measurements to constrain six spatially flat and non-flat cosmological models. These three sets of cosmological constraints are mutually consistent. Cosmological constraints from a joint analysis of these data sets are largely consistent with currently accelerating cosmological expansion and with cosmological constraints derived from a combined analysis of Hubble parameter (H(z)) and baryon acoustic oscillation (BAO, with Planck-determined baryonic matter density) measurements. A joint analysis of the H(z) + BAO + QSO-AS + H iiG + GRB data provides fairly model-independent determinations of the non-relativistic matter density parameter $\Omega _{\rm m_0}=0.313\pm 0.013$ and the Hubble constant $H_0=69.3\pm 1.2\, \rm {km \, s^{-1} \, Mpc^{-1}}$. These data are consistent with the dark energy being a cosmological constant and with spatial hypersurfaces being flat, but they do not rule out mild dark energy dynamics or a little spatial curvature. We also investigate the effect of including quasar flux measurements in the mix and find no novel conclusions.
GG Carinae: orbital parameters and accretion indicators from phase-resolved spectroscopy and photometry
Authors: Porter Augustus , Grant David , Blundell Katherine , Lee Steven 
Published: December 2020

ABSTRACT
B[e] supergiants are a rare and unusual class of massive and luminous stars, characterized by opaque circumstellar envelopes. GG Carinae is a binary whose primary component is a B[e] supergiant and whose variability has remained unsatisfactorily explained. Using photometric data from ASAS, OMC, and ASAS-SN and spectroscopic data from the Global Jet Watch and FEROS to study visible emission lines, we focus on the variability of the system at its ∼31-d orbital period and constrain the stellar parameters of the primary. There is one photometric minimum per orbital period and, in the emission line spectroscopy, we find a correlation between the amplitude of radial velocity variations and the initial energy of the line species. The spectral behaviour is consistent with the emission lines forming in the primary’s wind, with the variable amplitudes between line species being caused by the less energetic lines forming at larger radii on average. By modelling the atmosphere of the primary, we are able to model the radial velocity variations of the wind lines in order to constrain the orbit of the binary. We find that the binary is even more eccentric than previously believed (e = 0.5 ± 0.03). Using this orbital solution, the system is brightest at periastron and dimmest at apastron, and the shape of the photometric variations at the orbital period can be well described by the variable accretion by the secondary of the primary’s wind. We suggest that the evolutionary history of GG Carinae may need to be re-evaluated in a binary context.
“We Need to Taper.” Interviews with Clinicians and Pharmacists About Use of a Pharmacy-Led Opioid Tapering Program
Authors: Firemark Alison J , Schneider Jennifer L , Kuntz Jennifer L , Papajorgji-Taylor Dea , Dickerson John F , Thorsness Lou Ann , Reese Katherine R , Sullivan Mark D , Debar Lynn L , Smith David H 
Published: December 2020

AbstractObjectiveTo identify factors that influence or interfere with referrals by primary care providers (PCPs) to a pharmacist-led telephone-based program to assist patients undergoing opioid tapering. The Support Team Onsite Resource for Management of Pain (STORM) program provides individualized patient care and supports PCPs in managing opioid tapers.DesignQualitative interviews were conducted with referring PCPs and STORM staff. Interview guides addressed concepts from the RE-AIM framework, focusing on issues affecting referral to the STORM program.SettingAn integrated healthcare system (HCS) in the Northwest United States.SubjectsThirty-five interviews were conducted with 20 PCPs and 15 STORM staff.MethodsConstant comparative analysis was used to identify key themes from interviews. A codebook was developed based on interview data and a qualitative software program was used for coding, iterative review, and content analysis. Representative quotes illustrate identified themes.ResultsUse of the STORM opioid tapering program was influenced by PCP, patient, and HCS considerations. Factors motivating use of STORM included lack of PCP time to support chronic pain patients requiring opioid tapering and the perception that STORM is a valued partner in patient care. Impediments to referral included PCP confidence in managing opioid tapering, patient resistance to tapering, forgetting about program availability, and PCP resistance to evolving guidelines regarding opioid tapering goals.ConclusionsPCPs recognized that STORM supported patient safety and reduced clinician burden. Utilization of the program could be improved through ongoing PCP education about the service and consistent co-location of STORM pharmacists within primary care clinics.