bluuebunny/crossref_metadata_2025_split huggingface dataset:
Absolute reliability of tongue pressure measurement in young healthy adults and elderly patients with certification of needing long‐term care or support
Authors: Sawaya Yohei , Ishizaka Masahiro , Kubo Akira , Shiba Takahiro , Sato Tamae , Onoda Ko , Maruyama Hitoshi , Urano Tomohiko 
Published: March 2020

AimWe aimed to determine systematic bias and the range of random error in tongue pressure measurements among young healthy adults and elderly patients with certification of requiring long‐term care or support, considering sex, and to establish a measurement method.MethodsSubjects were 226 adults (88 young healthy adults and 138 elderly patients with certification of requiring long‐term care or support). Tongue pressure was measured thrice. Bland–Altman analysis was performed for the first and second trials, and second and third trials.ResultsFixed bias was revealed for the first and second trials among young healthy adults. Systematic bias was not found for the second and third trials. Fixed bias was revealed for the first and second trials among elderly patients, with a proportional bias with a negative slope for the second and third trials. For young healthy adults, the minimal detectable change was 6.0 and 5.4 kPa in males and females, respectively. For elderly patients, the limit of agreement ranged from −5.9 to 8.6 and from −5.4 to 8.8 kPa in males and females, respectively.ConclusionsThere was a difference in systematic bias in tongue pressure measurement between young healthy adults and elderly patients with certification of needing long‐term care or support. In young healthy adults, the third trial results showed stability, whereas they decreased in elderly patients. In elderly patients, it was suggested that the number of measurements reduced from three to two when a maximum value was adopted. No differences were observed among sexes in either young or elderly patients. Geriatr Gerontol Int 2020; 20: 488–493.
Helicobacter pylorifirst‐line and rescue treatments in patients allergic to penicillin: Experience from the European Registry onH pylorimanagement (Hp‐EuReg)
Authors: Nyssen Olga P. , Pérez‐Aisa Ángeles , Tepes Bojan , Rodrigo‐Sáez Luis , Romero Pilar M. , Lucendo Alfredo , Castro‐Fernández Manuel , Phull Perminder , Barrio Jesús , Bujanda Luis , Ortuño Juan , Areia Miguel , Brglez Jurecic Natasa , Huguet José María , Alcaide Noelia , Voynovan Irina , María Botargues Bote José , Modolell Inés , Pérez Lasala Jorge , Ariño Inés , Jonaitis Laimas , Dominguez‐Cajal Manuel , Buzas György , Lerang Frode , Perona Monica , Bordin Dmitry , Axon Toni , Gasbarrini Antonio , Marcos Pinto Ricardo , Niv Yaron , Kupcinskas Limas , Tonkic Ante , Leja Marcis , Rokkas Theodore , Boyanova Lyudmila , Shvets Oleg , Venerito Marino , Bytzer Peter , Goldis Adrian , Simsek Ilkay , Lamy Vincent , Przytulski Krzysztof , Kunovský Lumír , Capelle Lisette , Milosavljevic Tomica , Caldas María , Garre Ana , Mégraud Francis , O'Morain Colm , Gisbert Javier P. ,   the Hp‐EuReg Investigators
Published: March 2020

AbstractBackgroundExperience inHelicobacter pylorieradication treatment of patients allergic to penicillin is very scarce. A triple combination with a PPI, clarithromycin (C), and metronidazole (M) is often prescribed as the first option, although more recently the use of a quadruple therapy with PPI, bismuth (B), tetracycline (T), and M has been recommended.AimTo evaluate the efficacy and safety of first‐line and rescue treatments in patients allergic to penicillin in the “European Registry ofH pylorimanagement” (Hp‐EuReg).MethodsA systematic prospective registry of the clinical practice of European gastroenterologists (27 countries, 300 investigators) on the management ofH pyloriinfection. An e‐CRF was created on AEG‐REDCap. Patients with penicillin allergy were analyzed until June 2019.ResultsOne‐thousand eighty‐four patients allergic to penicillin were analyzed. The most frequently prescribed first‐line treatments were as follows: PPI + C + M (n = 285) and PPI + B + T + M (classic or Pylera®; n = 250). In first line, the efficacy of PPI + C + M was 69%, while PPI + B + T + M reached 91% (P < .001). In second line, after the failure of PPI + C + M, two rescue options showed similar efficacy: PPI + B + T + M (78%) and PPI + C + levofloxacin (L) (71%) (P > .05). In third line, after the failure of PPI + C + M and PPI + C + L, PPI + B + T + M was successful in 75% of cases.ConclusionIn patients allergic to penicillin, a triple combination with PPI + C + M should not be generally recommended as a first‐line treatment, while a quadruple regimen with PPI + B + T + M seems to be a better option. As a rescue treatment, this quadruple regimen (if not previously prescribed) or a triple regimen with PPI + C + L could be used but achieved suboptimal (<80%) results.
Exploring the influence of family on adolescents’ seafood consumption choices
Authors: Birch Dawn , Memery Juliet 
Published: March 2020

AbstractSeafood in the adolescent diet has many benefits, yet a number of adolescents do not consume the recommended levels. Despite this the consumption of seafood by younger consumers has received scant attention in the extant literature. Previous studies on adolescents’ food‐related behaviour tend to focus on general choice mechanisms or perceptions of food and mainly relate to fruit and vegetable intake. The present study seeks to address this gap through investigating the impact of family upon the consumption of seafood by younger consumers through exploring adolescents’ attitudes and behaviour in regard to eating seafood. Utilizing an exploratory qualitative methodology, seven focus groups of adolescents aged 13–19 years were conducted at two schools in South West England. Discussions covered a range of issues related to adolescent seafood consumption. The use of thematic content analysis found that the family, and parents in particular, exert high levels of influence over adolescents’ consumption of seafood both at home and when dining out. The parent who does the shopping and cooking has the greatest role. Sibling preferences and dietary choices also influence whether seafood is served in the home. Of value to researchers and management are the insights gleaned into the influences on adolescents’ attitudes towards and behaviour in regard to eating seafood. In particular, encouraging seafood consumption will rely upon interventions aimed at both parents and children and need to take into account adolescents’ diet and lifestyle preferences, while also acknowledging the influence of peers and the school food environment.
Using text analysis software to detect deception in written short‐answer questions in employee selection
Authors: Forsyth Loch , Anglim Jeromy 
Published: March 2020

AbstractThis study investigated if word frequencies informed by the Newman‐Pennebaker (NP) and Reality Monitoring (RM) models could classify honest and deceptive responses to short‐answer questions often used in online employee applications. Participants (n = 106; 58% male; Mage = 30.28 years, SD = 8.85) completed two written short‐answer questions both deceptively and honestly. The questions asked participants to describe a notable personal achievement or a time where they had demonstrated interpersonal skills. Linguistic Inquiry and Word Count was used to calculate the prevalence of words in various linguistic categories. Deceptive statements contained significantly fewer first‐person singular pronouns, auxiliary verbs, adverbs, conjunctions, and cognitive process words. Results revealed the NP and RM models accuracy at classifying responses varied on question type.
Clamoring for greenbacks: Explaining the resurgence of the U.S. dollar in international debt
Authors: Ito Hiro , Rodriguez Cesar M. 
Published: March 2020

AbstractThis paper characterizes trends of the shares of the U.S. dollar, the euro, and total foreign currencies in international debt denomination over the last two decades. We find that countries with a high output growth trend, greater financial development, better fiscal conditions, and more investment opportunities tend to decrease the extent of their reliance on the dollar, but increase that on the euro, while their dependency on total foreign currencies remains unaffected. Stronger trade ties with the United States (the euro area) contribute to a higher dollar (euro) share in the currency denomination of international debt securities. We also find that absent from the global financial crisis (GFC), the dollar (euro) share in debt denomination would have been higher (lower) than the observed shares in the postcrisis period. That suggests that the outbreak of the GFC increased the demand for the dollar as a safe haven.
Workplace violence against nurses in health care and the role of human resource management: A systematic review of the literature
Authors: Pariona‐Cabrera Patricia , Cavanagh Jillian , Bartram Timothy 
Published: March 2020

AbstractAimTo provide insights into how workplace violence has an impact on nurses and to inform human resource management about developing comprehensive strategies to manage and mitigate violence.DesignA systematic review of the literature to appraise contemporary studies, source data and synthesize findings for human resource management to implement practices to mitigate violence against nurses in the healthcare sector.Data SourcesSearches were conducted using ProQuest, Business Source Complete (EBSCO), Emerald Insight, PsycINFO (ProQuest), ScienceDirect, and Google Scholar. Our search was delimited to refereed journal articles and government reports over the last 15 years from 2004–2019 and included a total of 71 articles.Review MethodsThe research team systematically reviewed each article and relative reports, eliminating any not considered relevant to nurses. This systematic review is associated with and reflects contemporary issues around nurses, violence, and human resource management practice.ResultsIn the studies we found high incidents of violence against nurses in the workplace. However, human resource management fundamentally services as an administrator, managing compliance and does not do enough to methodically mitigate and manage acts of violence in the workplace and its effects on nurses’ mental health.ConclusionsThis systematic review contributes to the literature on violence in health care and proposes that human resource management must explore and implement practices towards mitigating violence against nurses.ImpactThis systematic review will influence how human resource management currently manages violence against nurses and the increasing number of persons requiring health care due to the ageing population and decline in the number of nurses. It will also have an impact on action research to engage in a cycle of continuous improvement that supports eliminating violence against nurses (and all others) in the healthcare sector.
Novel variants in TECRL cause recessive inherited CPVT type 3 with severe and variable clinical symptoms
Authors: Moscu‐Gregor Alexander , Marschall Christoph , Müntjes Carsten , Schönecker Anne , Schuessler‐Hahn Franziska , Hohendanner Felix , Parwani Abdul Shokor , Boldt Leif‐Hendrik , Ott Claus‐Eric , Bennewiz Anja , Paul Thomas , Krause Ulrich , Rost Imma 
Published: March 2020

AbstractIntroductionCatecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia syndrome characterized by adrenergically stimulated ventricular tachycardia. The most common form of CPVT is due to autosomal dominant variants in the cardiac ryanodine‐receptor gene (RYR2). However, trans‐2,3‐enoyl‐CoA reductase‐like (TECRL) was recently suggested to be a novel candidate gene for life‐threatening inherited arrhythmias. Patients previously reported with pathogenic changes in TECRL showed a special mixed phenotype of CPVT and long‐QT‐syndrome (LQTS) termed CPVT type 3 (CPVT3), an autosomal recessive disorder.Methods and ResultsWe implemented TECRL into our NGS panel diagnostics for CPVT and LQTS in April 2017. By December 2018, 631 index patients with suspected CPVT or LQTS had been referred to our laboratory for genetic testing. Molecular analysis identified four Caucasian families carrying novel variants in TECRL. One patient was homozygous for Gln139* resulting in a premature stop codon and loss‐of‐function of the TECRL protein. Another patient was homozygous for Pro290His, probably leading to an altered folding of the 3‐oxo‐5‐alpha steroid 4‐dehydrogenase domain of the TECRL protein. The LOF‐variant Ser309* and the missense‐variant Val298Ala have been shown to be compound heterozygous in another individual. NGS‐based copy number variation analysis and quantitative PCR revealed a quadruplication of TECRL in the last individual, which is likely to be a homozygous duplication.ConclusionThe data from our patient collective indicate that CPVT3 occurs much more frequently than previously expected. Variants in TECRL may be causative in up to 5% of all CPVT cases. According to these findings, the default analysis of this gene is recommended if CPVT is suspected.
The predictive value of heart rate variability indices tested in early period after radiofrequency catheter ablation for the recurrence of atrial fibrillation
Authors: Zhu Zhenyan , Wang Weiming , Cheng Yamin , Wang Xiaoqing , Sun Jianhui 
Published: March 2020

AbstractIntroductionTo explore the relationship between recurrence of atrial fibrillation (AF) and the autonomic nervous activity evaluated by heart rate variability (HRV) indices after radiofrequency catheter ablation (RFCA) in the early period.MethodsWe enrolled 102 patients with paroxysmal AF and tested the HRV indices by the high‐resolution Holter electrocardiogram the next morning after RFCA. The HRV indices were compared between the non‐recurrence group (n = 85) and the recurrence group (n = 17).ResultsThe HRV indices included standard deviation of normal to normal intervals (SDNN), SDNN index, root‐mean square successive differences (RMSSD), the proportion of normal to normal intervals differing by >50 millisecond (ms) (pNN50), high‐frequency components (HF), low‐frequency components (LF) and very low‐frequency components were significantly higher in recurrence group than that in non‐recurrence group, while no such difference was found for LF/HF. Based on the median value of the recurrent time (9 months), RMSSD (P = .012), pNN50 (P < .0001) and HF (P = .033) were lower in late recurrence group than that in early recurrence group. The Cox regression analyses indicated that higher values of RMSSD (P = .01), pNN50 (P = .02) and HF (P = .02) were associated with a higher risk of recurrence after adjusted for covariates. The receiver operating characteristic curves showed higher rates of clinical recurrence of AF after RFCA in patients with RMSSD ≥27.5 ms, pNN50 ≥4.5%, and HF ≥178.25 ms2.ConclusionsValues of RMSSD, pNN50, and HF tested in the early period after RFCA could independently predict the recurrence of AF.
Secular trends in hypertension and elevated blood pressure among Korean children and adolescents in the Korea National Health and Nutrition Examination Survey 2007‐2015
Authors: Cho Heeyeon , Kim Jae Hyun 
Published: March 2020

AbstractThe prevalence of elevated blood pressure (BP) among US children and adolescents has reportedly declined over the past decade. As no Korean data have been analyzed, we aimed to determine recent trends in BP levels among Korean children and adolescents. This study examines data from the Korea National Health and Nutrition Examination Survey segregated into 3 time periods (2007‐2009, 2010‐2012, and 2013‐2015). A total of 7804 Korean children and adolescents aged 10‐18 years were included in the analysis. Hypertension (≥95th percentile) and elevated BP (>90th percentile) were defined using the sex‐, age‐, and height‐specific BP standards from 2017 American Academy of Pediatrics guidelines. Mean systolic BP from 2007‐2009 to 2013‐2015 increased by 3.9 mm Hg, and there was no significant change in diastolic BP. Body mass index (BMI) z‐scores significantly increased in the total population from 2007‐2009 to 2013‐2015. In 2013‐2015, the prevalence rates of elevated BP and hypertension were 8.8% and 9.0%, respectively. The prevalence of hypertension in 2013‐2015 increased in the total population compared with those in 2007‐2009, especially in the obese subgroup, in which the hypertension prevalence was 27.7% in 2013‐2015. The prevalence of elevated BP increased during these time period. Associated factors were sex, age, BMI z‐score, and survey period for elevated BP; and sex, age, and BMI z‐score for hypertension. During our study, mean systolic BP increased, and the prevalence of hypertension in 2013‐2015 increased in the pediatric population. A possible influencing factor is obesity, and further long‐term data are necessary.
Renovascular hypertension from the BCR‐ABL tyrosine kinase inhibitor ponatinib
Authors: Amin Syed O. , Ruzicka Marcel , Burns Kevin D. , Bence‐Bruckler Isabelle A. , Ryan Stephen E. , Hadziomerovic Adnan , Hiremath Swapnil 
Published: March 2020

AbstractDrug‐induced hypertension is one of the commonest causes of secondary hypertension. In the last few years, secondary hypertension due to tyrosine kinase inhibitors, from the vascular endothelial growth factor class, has been recognized to be an important cause of hypertension, as well as proteinuria, and occasionally kidney dysfunction in some cases. Less well‐recognized is that BCR‐ABL tyrosine kinase inhibitors also have adverse vascular effects. These manifest as vascular stenoses in large vessels, which may sometimes cause renal artery stenosis and subsequent hypertension. We describe a case report which presented as classical bilateral renal artery stenosis, and responded to revascularization. Increased awareness of these effects, as well as research into the pathogenesis, may provide more insight into vascular biology.
Drinking frequency modifies an association between salt intake and blood pressure: A cohort study
Authors: Yoshimura Ryuichi , Yamamoto Ryohei , Shinzawa Maki , Tomi Ryohei , Ozaki Shingo , Fujii Yoshiyuki , Ito Takafumi , Tanabe Kazuaki , Moriguchi Yasuaki , Isaka Yoshitaka , Moriyama Toshiki 
Published: March 2020

AbstractSalt sensitivity is one of the crucial risk factors of hypertension. The aim of the present prospective cohort study was to assess the clinical impact of alcohol drinking on an association between salt intake and blood pressure. The present study included 451 employees at a pharmaceutical company in Japan who underwent annual health checkups in both 2017 and 2018. The main exposure of interest was self‐reported drinking frequency at their first checkups: rarely, occasionally, and daily. To assess the association between the change of salt intake estimated from single‐spot urine specimens and that of blood pressure, the differences in systolic/diastolic blood pressure and salt intake between 2017 and 2018 were calculated for each subject. Multivariable‐adjusted linear regression models adjusting for clinically relevant factors clarified a drinking frequency‐dependent association between Δsalt intake and Δsystolic blood pressure (per 1 g/d of Δsalt intake adjusted β [95% confidence interval] 0.19 [−0.73, 1.12], 0.84 [0.14, 1.53], and 1.78 [0.86, 2.69] in rare, occasional, and daily drinkers). A similar association between Δsalt intake and Δdiastolic blood pressure was also observed (−0.24 [−1.02, 0.54], 0.67 (0.18, 1.16), 0.95 [0.38, 1.51], in rare, occasional, and daily drinkers). The interactions between drinking frequency and Δsalt intake were found to be statistically significant (P for interaction = .028 and .006 for ∆systolic blood pressure and ∆diastolic blood pressure, respectively). The present study identified enhanced salt sensitivity in the subjects who drink at a higher frequency, suggesting that the reduction in alcohol consumption may improve salt sensitivity in higher frequency drinkers.
Role of leptin in the regulation of food intake in fasted mice
Authors: Ge Tong tong , Yao Xiao Xiao , Zhao Feng Lian , Zou Xiao han , Yang Wei , Cui Ran Ji , Li Bing jin 
Published: March 2020

AbstractLeptin is well acknowledged as an anorexigenic hormone that plays an important role in feeding control. Hypothalamic GABA system plays a significant role in leptin regulation on feeding and metabolism control. However, the pharmacological relationship of leptin and GABA receptor is still obscure. Therefore, we investigated the effect of leptin or combined with baclofen on the food intake in fasted mice. We detected the changes in hypothalamic c‐Fos expression, hypothalamic TH, POMC and GAD67 expression, plasma insulin, POMC and GABA levels to demonstrate the mechanisms. We found that leptin inhibit fasting‐induced increased food intake and activated hypothalamic neurons. The inhibitory effect on food intake induced by leptin in fasted mice can be reversed by pretreatment with baclofen. Baclofen reversed leptin's inhibition on c‐Fos expression of PAMM in fasted mice. Therefore, these results indicate that leptin might inhibit fasting‐triggered activation of PVN neurons via presynaptic GABA synaptic functions which might be partially blocked by pharmacological activating GABA‐B. Our findings identify the role of leptin in the regulation of food intake.
Sleep across early childhood: implications for internalizing and externalizing problems, socioemotional skills, and cognitive and academic abilities in preschool
Authors: Hoyniak Caroline P. , Bates John E. , McQuillan Maureen E. , Staples Angela D. , Petersen Isaac T. , Rudasill Kathleen M. , Molfese Victoria J. 
Published: March 2020

BackgroundSleep is thought to be important for behavioral and cognitive development. However, much of the prior research on sleep's role in behavioral/cognitive development has relied upon self‐report measures and cross‐sectional designs.MethodsThe current study examined how early childhood sleep, measured actigraphically, was developmentally associated with child functioning at 54 months. Emphasis was on functioning at preschool, a crucial setting for the emergence of psychopathology. Participants included 119 children assessed longitudinally at 30, 36, 42, and 54 months. We examined correlations between child sleep and adjustment across three domains: behavioral adjustment (i.e., internalizing and externalizing problems), socioemotional skills, and academic/cognitive abilities. We further probed consistent associations with growth curve modeling.ResultsInternalizing problems were associated with sleep variability, and cognitive and academic abilities were associated with sleep timing. Growth curve analysis suggested that children with more variable sleep at 30 months had higher teacher‐reported internalizing problems in preschool and that children with later sleep timing at 30 months had poorer cognitive and academic skills at 54 months. However, changes in sleep from 30 to 54 months were not associated with any of the domains of adjustment.ConclusionsFindings indicate that objectively measured sleep variability and late sleep timing in toddlerhood are associated with higher levels of internalizing problems and poorer academic/cognitive abilities in preschool.