bluuebunny/crossref_metadata_2025_split huggingface dataset:
Testing single/combined clinical categories on 5110 Italian patients with developmental phenotypes to improve array‐based detection rate
Authors: Catusi Ilaria , Recalcati Maria Paola , Bestetti Ilaria , Garzo Maria , Valtorta Chiara , Alfonsi Melissa , Alghisi Alberta , Cappellani Stefania , Casalone Rosario , Caselli Rossella , Ceccarini Caterina , Ceglia Carlo , Ciaschini Anna Maria , Coviello Domenico , Crosti Francesca , D'Aprile Annamaria , Fabretto Antonella , Genesio Rita , Giagnacovo Marzia , Granata Paola , Longo Ilaria , Malacarne Michela , Marseglia Giuseppina , Montaldi Annamaria , Nardone Anna Maria , Palka Chiara , Pecile Vanna , Pessina Chiara , Postorivo Diana , Redaelli Serena , Renieri Alessandra , Rigon Chiara , Tiberi Fabiola , Tonelli Mariella , Villa Nicoletta , Zilio Anna , Zuccarello Daniela , Novelli Antonio , Larizza Lidia , Giardino Daniela 
Published: December 2019

AbstractBackgroundChromosomal microarray analysis (CMA) is nowadays widely used in the diagnostic path of patients with clinical phenotypes. However, there is no ascertained evidence to date on how to assemble single/combined clinical categories of developmental phenotypic findings to improve the array‐based detection rate.MethodsThe Italian Society of Human Genetics coordinated a retrospective study which included CMA results of 5,110 Italian patients referred to 17 genetics laboratories for variable combined clinical phenotypes.ResultsNon‐polymorphic copy number variants (CNVs) were identified in 1512 patients (30%) and 615 (32%) present in 552 patients (11%) were classified as pathogenic. CNVs were analysed according to type, size, inheritance pattern, distribution among chromosomes, and association to known syndromes. In addition, the evaluation of the detection rate of clinical subgroups of patients allowed to associate dysmorphisms and/or congenital malformations combined with any other single clinical sign to an increased detection rate, whereas non‐syndromic neurodevelopmental signs and non‐syndromic congenital malformations to a decreased detection rate.ConclusionsOur retrospective study resulted in confirming the high detection rate of CMA and indicated new clinical markers useful to optimize their inclusion in the diagnostic and rehabilitative path of patients with developmental phenotypes.
Highly reduced mutual coupling between wideband patch antenna array using multiresonance EBG structure and defective ground surface
Authors: Sokunbi Oludayo , Attia Hussein 
Published: December 2019

AbstractThis paper presents a novel slotted wideband microstrip patch antenna array with 2 decoupling structures that enabled isolation enhancement between 10 and 40 dB throughout the operating bandwidth of 4‐6.5 GHz. Four asymmetrical patches were first used as a unit cell to produce a multiresonance electromagnetic band gap (EBG) structure capable of increasing the isolation between the patch array by about 50 dB within the impedance bandwidth of 5.8‐6.4 GHz. By introducing 3 double F‐shaped etchings in the array ground plane, the isolation bandwidth is extended to 4.0‐6.5 GHz (ie, 48%) with measured isolation improvement of 10‐40 dB over the entire isolation bandwidth. The multiresonance EBG structure mitigates the surface waves propagating in the substrate while the double F‐shaped ground plane reduces the surface waves traveling on the ground plane. The edge‐to‐edge spacing between the 2 patch antennas is 25.2 mm which is equivalent to 0.42 λ0 (λ0 is the free‐space wavelength at the center frequency of 5.0 GHz). After loading the decoupling structures in the antenna array, the gain increased from 5.6 dB to 7 dB. The proposed antenna is fabricated and there is an acceptable agreement between the simulated and measured results. The antenna radiation characteristics are observed to be fairly consistent over the large operating bandwidth of 4‐6.5 GHz. The proposed antenna is a potential candidate for wideband wireless applications in the sub‐6 GHz band.
Treatment of pediatric high‐grade central nervous system tumors with high‐dose methotrexate in combination with multiagent chemotherapy: A single‐institution experience
Authors: Bernstock Joshua D. , Alva Elizabeth , Cohen Joshua L. , Lobbous Mina , Chagoya Gustavo , Elsayed Galal A. , Orr Brent A. , Rozzelle Curtis , Rocque Brandon , Blount Jeffrey , Johnston James M. , Li Rong , Fiveash John B. , Dhall Girish , Reddy Alyssa T. , Friedman Gregory K. 
Published: December 2019

AbstractBackgroundEffective treatment for pediatric embryonal brain tumors includes dose‐intensive multiagent chemotherapy (DIMAC) followed by high‐dose chemotherapy with stem cell rescue (HDCSCR). Use of repeated cycles of DIMAC including high‐dose methotrexate (HDMTX) without HDCSCR has not been described.ProcedureWe retrospectively reviewed the responses/toxicities in 13 patients (aged 2‐155 months, median 22 months) with central nervous system (CNS) tumors (atypical teratoid rhabdoid tumors, CNS embryonal tumors not otherwise specified, pineoblastoma, embryonal tumor with multilayered rosettes, and CNS sarcoma) treated over a 12‐year period with repeated cycles of HDMTX followed by etoposide, cisplatin, cyclophosphamide, and vincristine.ResultsSix patients (46.2%) had disseminated disease at presentation and five (38.5%) had gross total resection. A total of 64 courses of therapy were administered with a median of five courses per patient. Eight patients (61.5%) received radiation therapy (one at relapse). By completion of therapy, 11 patients (84.6%) achieved a response (six complete, five partial). Six of the 13 patients (46.2%) remain alive with a median follow‐up of 48 months (6‐146). Acute toxicities included fever/neutropenia (70.3%), bacteremia (15.6%), and grade 3 mucositis (18.8%). Long‐term complications included learning disability, seizure disorder, and brain necrosis, without treatment‐related deaths.ConclusionsDIMAC with HDMTX without HDCSCR may be an effective treatment option for selected patients with embryonal or high‐grade CNS tumors.
Turbulence and entrainment in an atmospheric pressure dielectric barrier plasma jet
Authors: Morabit Youssef , Whalley Richard D. , Robert Eric , Hasan Mohammad I. , Walsh James L. 
Published: December 2019

AbstractParticle image velocimetry, laser‐induced fluorescence, and computational modeling are used to quantify the impact of plasma generation on air entrainment into a helium plasma jet. It is demonstrated that discharge generation yields a minor increase in the exit velocity of the gas. In contrast, the laminar to turbulent transition point is strongly affected, attributed to an increase in plasma‐induced perturbations within the jet shear layer. The temporal decay of laser‐induced fluorescence from OH is used as an indicator of humid air within the plasma. The results show that plasma‐induced perturbations increase the quenching rate of the OH‐fluorescent state; indicating that shear‐layer instabilities play a major role in determining the physicochemical characteristics of the plasma.
Fabrication of Spinel Cobalt Ferrite (CoFe2O4) Nanoparticles with Unique Earth Element Cerium and Neodymium for Anticandidal Activities
Authors: Rehman Suriya , Almessiere Munerah Abdullah , Tashkandi Nedaa , Baykal Abdulhadi , Slimani Yassine , Jermy Rabindran , Ravinayagam Vijaya , Yaman Cevat 
Published: December 2019

AbstractThe present study, demonstrates the synthesis of spinel cobalt ferrite (CoFe2O4) nanoparticles (NPs), substituted with various concentrations of unique earth element neodymium (Nd3+) and Cerium (Ce3+), by sonochemical technique. Further examination for the influence of Nd3+ and Ce3+ on structure, surface morphology and anticandidal activities, using different techniques X‐ray diffraction pattern (XRD), scanning electron microscopy (SEM) coupled with Energy‐dispersive X‐ray (EDX) and transmission electron microscopy (TEM) were studied. The nanocrystalline size ranging from 11 to 16 nm with spherical shaped particles were obtained. The anticandidal effect of Nd3+ and Ce3+ doped cobalt ferrite NPs were studied against Candida albicans by evaluating the CFU (colony forming unit) and morphogenesis by SEM. The treatment with Nd3+ and Ce3+ doped cobalt ferrite nanoparticles, showed profound activity with the increasing ratio of Nd3+ and Ce3+ and in an incubation duration manner. The lowest survivability i. e. 40 and 30%, and maximum morphogenesis was obtained with x=0.15 and x=0.2, respectively. The findings lead to the conclusion, that the synthesized NPs have potential as therapeutic strategy targeting Candida infection, and other biomedical applications.
Molecular Docking and Recent Advances in the Design and Development of Cholinesterase Inhibitor Scaffolds: Coumarin Hybrids
Authors: Hasan Aso Hameed , Amran Syazwani Itri , Saeed Hussain Faiq Hama , Jaff Baram Ahmed , Jamalis Joazaizulfazli 
Published: December 2019

AbstractAlzheimer is a deadly neurodegenerative disease that commonly attacks elderly people around the world. Therefore, this disease has drawn attention among the researchers to find new potent drugs to treat Alzheimer disease (AD) more efficiently. Coumarin containing scaffold is a potential AD agent. Coumarin hybrids are frequently used as a template to design novel therapeutic agent for the treatment of AD, which are designed based on using molecular docking. As a result of docking studies shown that coumarin cores can occupy PAS by making extensive hydrophobic interactions with the residues in that region (mainly Trp279, Tyr70, Tyr121, Asp72, Phe290, Trp84, Phe330). The present review compiles research literature on the recent design strategies of coumarin hybrids with anti‐Alzheimer's activities and outlined docking studies.
In Situ Synthesis of C–Doped BiOBr Micron‐Flower by Structural Induction of Sodium Alginate for Rapid Removal Tetracycline
Authors: Zhang Zhancheng , Wang Bin , Guo Junhui , He Yufeng , Song Pengfei , Wang Rongmin 
Published: December 2019

AbstractC‐doped into the BiOBr is a big challenge because unique lattice structure. Here, using sodium alginate (SA) as the structure‐directing agent and C source, the C‐doped BiOBr micron‐flower (BiOBr‐SA) was in‐situ synthesized with KBr and Bi(NO3)3 with hydrothermal, and characterized by XRD, SEM, XPS, BET and DRS. It was found that SA could control morphology of BiOBr‐SA as it contains carboxylate groups. Meanwhile, C−Bi bonds were formed in nanosheets, and further self‐assembled into BiOBr‐SA micron‐flower. Using BiOBr‐SA as photocatalyst for degradation of antibiotic and dye, the removal rate of tetracycline got to 88.7%.
Nonpolar Interface Composition in Cetyltrimethylammonium Bromide Reverse Micellar Environments to Control Size and Induce Anisotropy on Gold Nanoparticles
Authors: Guerrero‐Florez Valentina , Blach Diana , Martínez O Fernando 
Published: December 2019

AbstractWe study the composition effect of non‐polar organic media in cetyltrimethylammonium bromide (CTAB) reverse micelles (RMs) on the interface properties and their use as nanoreactors for gold nanoparticles (AuNPs) synthesis. We evaluate how the molecular structure of aliphatic (n‐hexane) and aromatic (toluene) organic solvent influences the environments and interactions at the interface of n‐hexane/1‐butanol/CTAB and toluene/1‐butanol/CTAB RMs, as a key factor on AuNPs finals properties. Data show that the intermicellar exchange rate is affected by changing the organic solvent, and these facts influence AuNPs size, polydispersity, and morphology. FTIR and 1H NMR results suggest that in n‐hexane a rigid and compact micellar interface favors the formation of smaller AuNPs, while in toluene a more fluent micellar interface enhances the formation of larger and dispersed AuNPs. This specific interaction also affects the CTAB counterion (Br −) availability at the interface, which appears to be crucial to induce anisotropy of the AuNPs obtained.
Cn and Cn‐1B Fullerenes as Potential Nanovehicles for Piribedil Neuroprotective Drug (n=20, 36 and 60)
Authors: Reina Miguel , Celaya Christian A. , Muñiz Jesús 
Published: December 2019

AbstractPristine and boron‐doped fullerenes have been widely investigated for their possible use in medical applications, as drug delivery nanovehicles. In this study, we investigate bare and B‐doped C20, C36 and C60 fullerenes and their interaction with piribedil drug molecule, based on density functional theory (DFT). Calculations were performed using the functional PBE of general gradient approximation, empirical dispersion correction by Grimme under vacuum conditions, pentylethanoate and water media. In this article, we examine optimized geometries, binding energies, theoretical IR spectra and the plots of Molecular Electrostatic Potential, as well as HOMO and LUMO orbitals, density of states (DOS) and the quantum theory of atoms in molecules (QTAIM), in order to truly comprehend the interaction between various fullerenes and piribedil. Findings suggest that C36, C60 and C35B fullerenes might be used as drug delivery vehicles for piribedil because of their moderately high adsorption energies with piribedil.
Thinking beyond the score: Multidimensional analysis of student performance to inform the next generation of science assessments
Authors: Cardozo‐Gaibisso Lourdes , Kim Seohyun , Buxton Cory , Cohen Allan 
Published: December 2019

AbstractConventional assessment analysis of student results, referred to as rubric‐based assessments (RBA), has emphasized numeric scores as the primary way of communicating information to teachers about their students’ learning. In this light, rethinking and reflecting on not only how scores are generated but also what analyses are done with them to inform classroom practices is of utmost importance. Informed by Systemic Functional Linguistics and Latent Dirichlet Allocation analyses, this study utilizes an innovative bilingual (Spanish–English) constructed response assessment of science and language practices for middle and high school students to perform a multilayered analysis of student responses. We explore multiple ways of looking at students’ performance through their written assessments and discuss features of student responses that are made visible through these analyses. Findings from this study suggest that science educators would benefit from a multidimensional model which deploys complementary ways in which we can interpret student performance. This understanding leads us to think that researchers and developers in the field of assessment need to promote approaches that analyze student science performance as a multilayered phenomenon.
Neuronal diversity and reciprocal connectivity between the vertebrate hippocampus and septum
Authors: Iyer Archana , Tole Shubha 
Published: December 2019

AbstractA hallmark of the nervous system is the precision with which myriad cell types are integrated into functional networks that control complex behaviors. The limbic system governs evolutionarily conserved processes essential for survival. The septum and the hippocampus are central to the limbic system, and control not only emotion‐related behaviors but also learning and memory. Here, we provide a developmental and evolutionary perspective of the hippocampus and septum and highlight the neuronal diversity and circuitry that connects these two central components of the limbic system.This article is categorized under:Nervous System Development > Vertebrates: Regional DevelopmentNervous System Development > Vertebrates: General PrinciplesComparative Development and Evolution > Regulation of Organ Diversity
MR scan evaluation of pelvic organ prolapse mesh complications and agreement with intra-operative findings
Authors: Mahoney Charlotte , Hindle Adam , Rajashanker Balashanmugam , Kearney Rohna 
Published: December 2019

AbstractIntroductionAn increasing number of women are presenting with symptoms after the placement of mesh implants for prolapse which may be attributable to a mesh implant complication. MRI imaging can be used to evaluate abdominally placed mesh but there is no published research evaluating the use of MRI in this group of women. The objective of our study was to report our experience as a tertiary centre in evaluating abdominal mesh with MR imaging and the agreement of MR reports with surgical findings.Study designA retrospective observational cohort study (Canadian Task Force classification II-2) of all women referred to our tertiary unit who underwent an MR scan for investigation of symptoms of mesh complication following an abdominally placed mesh implant between June 2006 and September 2018 was performed. The reports of MR images were compared with the findings at surgery.ResultsMR scan was performed in 87 with suspected mesh complications. MR scan detected mesh failure in 42.1% of women (37/87), infection in 12.6% (11/87), compression in 2.3% (2/87), exposure in 12.6% (11/88), bowel extrusion in 2.3% (2/87) and inflammation in 11.5% (10/87). Agreement between MR scan report and surgical diagnosis was almost perfect for mesh failure, infection and compression, whilst agreement was only moderate for mesh erosion and signs of inflammation (failure κ = 0.97, infection κ = 0.94, compression κ = 1.0, exposure κ = 0.58 and inflammation κ = 0.24).ConclusionThese data provide information on the role of MR imaging in the investigation of women presenting with suspected intra-abdominal POP mesh complications including recurrence.
Risk factors of short-term survival in the aged in elective colon cancer surgery: a population-based study
Authors: Niemeläinen Susanna , Huhtala Heini , Ehrlich Anu , Kössi Jyrki , Jämsen Esa , Hyöty Marja 
Published: December 2019

Abstract
Purpose
Patients aged > 80 years represent an increasing proportion of colon cancer diagnoses. Selecting patients for elective surgery is challenging because of possibly compromised health status and functional decline. The aim of this retrospective, population-based study was to identify risk factors and health measures that predict short-term mortality after elective colon cancer surgery in the aged.

Methods
All patients > 80 years operated electively for stages I–III colon cancer from 2005 to 2016 in four Finnish hospitals were included. The prospectively collected data included comorbidities, functional status, postoperative surgical and medical outcomes as well as mortality data.

Results
A total of 386 patients (mean 84.0 years, range 80–96, 56% female) were included. Male gender (46% vs 35%, p = 0.03), higher BMI (51% vs 37%, p = 0.02), diabetes mellitus (51% vs 37%, p = 0.02), coronary artery disease (52% vs 36%, p = 0.003) and rheumatic diseases (67% vs 39%, p = 0.03) were related to higher risk of complications. The severe complications were more common in patients with increased preoperative hospitalizations (31% vs 15%, p = 0.05) and who lived in nursing homes (30% vs 17%, p = 0.05). The 30-day and 1-year mortality rates were 6.0% and 15% for all the patients compared with 30% and 45% in patients with severe postoperative complications (p < 0.001). Severe postoperative complications were the only significant patient-related variable affecting 1-year mortality (OR 9.60, 95% CI 2.33–39.55, p = 0.002).

Conclusions
The ability to identify preoperatively patients at high risk of decreased survival and thus prevent severe postoperative complications could improve overall outcome of aged colon cancer patients.
Identification of the NADH-oxidase gene in Trichomonas vaginalis
Authors: Lamien-Meda Aline , Leitsch David 
Published: December 2019

AbstractThe microaerophilic human parasite Trichomonas vaginalis causes infections in the urogenital tract and is one of the most often sexually transmitted pathogens worldwide. Due to its anaerobic metabolism, it has to quickly remove intracellular oxygen in order to avoid deactivation of essential metabolic enzymes such as oxygen-sensitive pyruvate:ferredoxin oxidoreductase (PFOR). Two major enzyme activities which are responsible for the removal, i.e. reduction, of molecular oxygen have been identified in T. vaginalis flavin reductase, formerly designated NADPH oxidase, which indirectly reduces oxygen to hydrogen peroxide via flavin mononucleotide (FMN), and NADH oxidase which reduces oxygen to water. Flavin reductase has been identified and characterized at the gene level as well as enzymatically, but NADH oxidase has so far only been characterized enzymatically with enzyme isolated from T. vaginalis cell extracts. In this study, we identified NADH oxidase by mass spectrometry after isolation of the enzyme from gel bands positively staining for NADH oxidase activity. In strain C1 (ATCC 30001) which is known to lack NADH oxidase activity completely, the NADH oxidase gene has a deletion at position 1540 of the open reading frame leading to a frame shift and, as a consequence, to premature termination of the encoded polypeptide.
Hydrogen Uptake of Duplex 2205 at H2 Partial Pressures up to 100 bar
Authors: Trautmann Anton , Mori Gregor , Siegl Wolfgang , Truschner Mathias , Pfeiffer Josefine , Kapp Marianne , Keplinger Andreas , Oberndorfer Markus , Bauer Stephan 
Published: December 2019

AbstractMicrobiological methanation is investigated in an underground natural gas reservoir. Since H2 is involved in the process, hydrogen embrittlement of steel must inevitably be considered. Therefore, a routine for testing has been developed and a unique autoclave test bench was designed to simulate field conditions. The 2205 duplex stainless steel (UNS S31803) was investigated. Constant load tests (CLTs) and immersion tests with subsequent hydrogen analyses were performed. The specimens were exposed to different partial pressures of H2 under both dry and wet conditions (with brine). Additionally, the influence of CO2 under wet conditions was covered. Tests were performed at two different temperatures (25 °C and 80 °C) and lasted for 30 days. In general, the duplex stainless steel shows a good resistance to hydrogen embrittlement, but a significantly higher hydrogen uptake was obtained compared to other steel grades.
Real-time diameter of the fetal aorta from ultrasound
Authors: Savioli Nicoló , Grisan Enrico , Visentin Silvia , Cosmi Erich , Montana Giovanni , Lamata Pablo 
Published: December 2019

AbstractThe automatic analysis of ultrasound sequences can substantially improve the efficiency of clinical diagnosis. This article presents an attempt to automate the challenging task of measuring the vascular diameter of the fetal abdominal aorta from ultrasound images. We propose a neural network architecture consisting of three blocks: a convolutional neural network (CNN) for the extraction of imaging features, a convolution gated recurrent unit (C-GRU) for exploiting the temporal redundancy of the signal, and a regularized loss function, calledCyclicLoss, to impose our prior knowledge about the periodicity of the observed signal. The solution is investigated with a cohort of 25 ultrasound sequences acquired during the third-trimester pregnancy check, and with 1000 synthetic sequences. In the extraction of features, it is shown that a shallow CNN outperforms two other deep CNNs with both the real and synthetic cohorts, suggesting that echocardiographic features are optimally captured by a reduced number of CNN layers. The proposed architecture, working with the shallow CNN, reaches an accuracy substantially superior to previously reported methods, providing an average reduction of the mean squared error from 0.31 (state-of-the-art) to 0.09$$\mathrm{mm}^2$$mm2, and a relative error reduction from 8.1 to 5.3%. The mean execution speed of the proposed approach of 289 frames per second makes it suitable for real-time clinical use.