P1447 Ascending aorta longitudinal strain in bicuspid aortic valve patients: a comparison with healthy volunteers and patients with degenerative aortic aneurysm
Authors: Guala A , Teixido-Tura G , Ruiz-Munoz A , Gandara M , Madrenas L , Izagirre N , Lopez Sainz A , Valente F , Galian L , Gonzalez-Alujas T , Servato L , Sao Aviles A , Evangelista A , Ferreira I , Rodriguez-Palomares J 
Published: January 2020

Abstract

Funding Acknowledgements
Spanish Ministry of Economy and Competitiveness RTC-2016-5152-1, ISCIII PI17/00381, La Marató de TV3 (20151330), Eur FP7/People 267128 and CIBERCV

Background
Histological findings of fibrillin-1 deficiency in bicuspid aortic valve (BAV) ascending aorta (AAo), as observed in Marfan (MFS), supported the existence of intrinsic aortic wall abnormalities, but recent studies reported the absence of an intrinsic impairment in stiffness. A recent study in MFS showed that AAo longitudinal strain was reduced in MFS and predicted dilation and aortic events. This parameter has not been studied in BAV.

Purpose
We investigated whether ascending aorta longitudinal strain is intrinsically altered in BAV with respect to tricuspid aortic valve (TAV) individuals.

Methods
80 BAV, 31 healthy volunteers (HV) and 29 TAV with AAo aneurysm, all without moderate valvular disease, were consecutively included. AAo dilation was defined as a z-score &gt; 2. The 1.5T CMR protocol included a set of 2D cine CMR stacks covering the proximal aorta in saggital, coronal and axial views. AAo longitudinal strain was computed by an in-house Matlab code performing a feature tracking of the aortic valve in each of the cine images.

Results
Twenty (25%) of BAV had AAo dilation. AAo longitudinal strain was lower in non-dilated BAV compared to HV, but the difference was not significant in multivariate analysis adjusted for AAo diameter and systolic blood pressure. Similarly, the difference between dilated BAV and dilated TAV found in univariate analysis was not confirmed by multivariate analysis. On the other hand, both dilated BAV and TAV showed decreased AAo longitudinal strain compared to HV, which were confirmed in multivariate analyses.

Conclusions
AAo longitudinal strain, a marker of aortic stiffness with predictive value in MFS, is not altered in BAV patients compared to TAV matched for dilation prevalence. Reduced AAo longitudinal strain was independently associated with dilation in both BAV and TAV.
Table 1 HV vs. NON-DILATED BAV DILATED BAV vs DILATED TAV HV vs. DILATED BAV HV vs. DILATED TAV HV NON-DILATED BAV Univariate /multivariate p-value DILATED TAV DILATED BAV Univariate /multivariate p-value Univariate/ Multivariate p-value Univariate p-value N 31 20 29 60 Age [years 35 ± 8 49 ± 16 &lt;0.001/ NS 66 ± 13 49 ± 14 &lt;0.001 / &lt;0.001 &lt;0.001 / 0.052 &lt;0.001 / NS Sex [% male] 42 35 0.629 24 42 0.097 / NS 0.969 0.149 BSA [m2] 1.83 ± 0.17 1.81 ± 0.14 0.702 1.95 ± 0.24 1.82 ± 0.22 0.015 / &lt;0.001 0.881 0.030 / NS SBP [mmHg] 119 ± 11 132 ± 16 0.002 / 0.029 133 ± 17 138 ± 19 0.304 &lt;0.001 / NS &lt;0.001 / NS DBP [mmHg] 69 ± 11 73 ± 6 0.099 / NS 77 ± 9 79 ± 11 0.455 &lt;0.001 / 0.016 0.004 / 0.023 Ascending aorta diameter [mm] 26 ± 4 33 ± 3 &lt;0.001 / 0.006 46 ± 7 43 ± 6 0.032 / NS &lt;0.001 / 0.001 &lt;0.001 /0.007 AAo long strain [%] 10.5 ± 3.6 8.4 ± 4.1 0.067/ NS 5.9 ± 2.7 7.7 ± 3.6 0.023 / NS 0.001 / 0.002 &lt;0.001 / 0.023 Demographics and uni- and multivariate analyses of AAo longitudinal strain