bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Suction and Blowing on Flow Separation in a Symmetric Sudden Expanded Channel
Authors: Layek G. C. C. , Midya C. , Mukhopadhyay S. 
Published: October 2019

A numerical simulation has been carried out to study the laminar flow in a symmetric sudden expanded channel subjected to a uniform blowing/suction speed placed at the lower and upper porous step walls. The governing equations for viscous flow have been solved using finite-difference techniques in pressure-velocity formulation. The results obtained here have been compared with the available experimental and numerical results of similar problems. It is noted that the recirculating region formed near the step walls diminishes in its length for increasing values of blowing speed applied at the porous step walls. For a suitable blowing speed, the recirculation zone disappears completely. The critical Reynolds number for the flow bifurcation (i.e. flow asymmetry) is obtained and it increases with the increase of the blowing speed. The critical Reynolds number for symmetry breaking of the flow decreases with the increasing values of suction speeds. The primary and the secondary recirculating regions formed near the channel walls are controlled using blowing.
Influence of staphylococcal Phage SAvB14 on biofilms, formed by Staphylococcus aureus variant bovis
Authors: Horiuk Y. V. , Kukhtyn M. D. , Stravskyy Y. S. , Klymnyuk S. I. , Vergeles K. M. , Horiuk V. V. 
Published: October 2019

The use of bacteriophages for the treatment of chronic inflammatory processes has proved to be relevant, especially during isolation of antibiotic-resistant pathogens formed in biofilms. The article presents the results of research on the influence of Phage SAvB14 on young and mature biofilms formed by Staphylococcus aureus variant bovis. In the experiments we used cultures of S. aureus and a specific Phage SAvB14 isolated from the secretion of the mammary gland of cows suffering from chronic mastitis. In the study of the influence of bacteriophage on formed biofilms we determined the optical density of the dye solution that was washed from the biofilm photometrically on a spectrophotometer PE-5400UV (Ecroskhim, Russia) and the number of staphylococcal cells in the biofilm after the action of the bacteriophage on 24-hour and 72-hour biofilms by a ten-fold dilution on beef-extract agar. It was determined that under the influence of the bacteriophage on young 24-hour biofilms of S. aureus var. bovis, the optical density of the dye solution from biofilm increased within 4 hours up to 10% and the number of microbial cells increased by 1.8 times. After 32 hours of bacteriophage action, the optical density of the dye solution decreased on average by 34% compared to the initial density and the number of S. aureus cells in the biofilm decreased by 30 times. This indicates that microbial cells of young biofilms are not subject to complete lysis during the action of even this specific bacteriophage. Degradation of 77.5% of biofilm under the influence of the bacteriophage was observed on mature 72-hour biofilm within 32 hours at 37 °C. At the same time, viable cells of S. aureus were not isolated from the biofilm. This indicates the high lytic activity of the bacteriophage against mature biofilm bacteria and the possibility of its use in chronic staphylococcal infections caused by S. aureus var. bovis. Thus, the obtained data indicate that when mature 72-hour biofilms are exposed to the researched bacteriophage, their degradation is more intense compared with the young 24-hour biofilms, and the amount of destroyed biofilm was on average 2 times higher. This suggests that the use of specific staphylococcal Phage SAvB14 isolated by us for the destruction of biofilm, formed by S. aureus var. bovis, is promising.
Regulation of physiological processes in winter wheat by growth regulators in conditions of powdery mildew infection
Authors: Mamenko Т. P. , Yakymchuk R. A. 
Published: October 2019

An important way of regulating the key units of metabolism in the plant organism under the action of stressors is the use of biologically active substances with regulating properties – plant growth regulators. They affect endogenous regulatory systems, altering key metabolic pathways and thus increasing the plant's sustainability and productive potential in adverse environmental conditions. The aim of the research was to establish the possibility of regulation of physiological processes in winter wheat varieties by exogenous treatment of plants with growth regulators of synthetic (salicylic acid) and natural (Emistim C and Biolan) origin to increase their resistance to the phytopathogen Erysiphe graminis DC f. sp. tritici Em. Marchal , the causative agent of powdery mildew. The intensity of the physiological processes in plants was evaluated by the dynamics of the activity of antioxidant enzymes – ascorbate peroxidase and catalase, the release of ethylene and the integrity of the cell membranes. The objects were selected varieties of soft winter wheat, which were grown in controlled growing conditions against the background of infection by powdery mildew. The treatment of plants was carried out using aqueous salicylic acid solutions in the concentration of 10–5 M (experimentally established by us), Emistim C and Biolan (manufacturer Agrobiotech) in the concentration specified by the manufacturer at the rate of 20 mL/ha, when the development of the disease reached 5% of the total natural background of the infection in the plants during the stages of heading-beginning of flowering. Infection of winter wheat with powdery mildew leads to disruption of cell membrane integrity, increased activity of catalase and ascorbate peroxidase in leaves of the susceptible winter wheat variety. The intensification of ethylene release by leaves of the resistant variety was observed, which was caused by the hypersensitive reaction of the hormone to the effect of stress. The use of plant treatment by growth regulators contributes to maintaining the integrity of membrane structures, adaptive changes in the activity of antioxidant enzymes and regulation of the synthesis of the stress hormone ethylene in both winter wheat varieties under stress. Such changes in the physiological processes induced by plant growth regulators are accompanied by the preservation of the grain productivity of winter wheat and the increase of their resistance to the development of the disease.
Health-Related Quality of Life in MONARCH 2: Abemaciclib plus Fulvestrant in Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer After Endocrine Therapy
Authors: Kaufman Peter A. , Toi Masakazu , Neven Patrick , Sohn Joohyuk , Grischke Eva-Maria , Andre Valerie , Stoffregen Clemens , Shekarriz Sarah , Price Gregory L. , Carter Gebra Cuyun , Sledge George W. 
Published: October 2019

AbstractBackgroundIn the phase III MONARCH 2 study (NCT02107703), abemaciclib plus fulvestrant significantly improved progression-free survival (PFS) versus placebo plus fulvestrant in patients with hormone receptor-positive (HR+), HER2-negative advanced breast cancer (ABC). This study assessed patient-reported pain, global health-related quality of life (HRQoL), functioning, and symptoms.Materials and MethodsAbemaciclib or placebo (150 p.o. mg twice daily) plus fulvestrant (500 mg, per label) were randomly assigned (2:1). The modified Brief Pain Inventory, Short Form (mBPI-sf); European Organization for Research and Treatment of Cancer (EORTC) QoL Core 30 (QLQ-C30); and Breast Cancer Questionnaire (QLQ-BR23) assessed outcomes. Data were collected at baseline, cycle 2, every two cycles 3–13, thereafter at every three cycles, and 30 days postdiscontinuation. Longitudinal mixed regression and Cox proportional hazards models assessed postbaseline change and time to sustained deterioration (TTSD) by study arm.ResultsOn-treatment HRQoL scores were consistently maintained from baseline and similar between arms. Patients in the abemaciclib arm (n = 446) experienced a 4.9-month delay in pain deterioration (mBPI-sf), compared with the control arm (n = 223), and significantly greater TTSD on the mBPI-sf and analgesic use (hazard ratio, 0.76; 95% CI, 0.59–0.98) and QLQ-C30 pain item (hazard ratio, 0.62; 95% CI, 0.48–0.79). TTSD for functioning and most symptoms significantly favored the abemaciclib arm, including fatigue, nausea and vomiting, and cognitive and social functioning. Only diarrhea significantly favored the control arm (hazard ratio, 1.60; 95% CI, 1.20–2.10).ConclusionHRQoL was maintained on abemaciclib plus fulvestrant. Alongside superior PFS and manageable safety profile, results support treatment with abemaciclib plus fulvestrant in a population of patients with endocrine-resistant HR+, HER2-negative ABC.
The Tragic Mulatta and Storytelling in Their Eyes Were Watching God
Authors: Pérez García Ana Belén 
Published: October 2019

The figure of the tragic mulatta placed its origin in antebellum literature and was extensively used in the literature of the nineteenth and twentieth century. Much has been written about this literary character in a time when the problem of miscegenation was at its highest point, and when studies established that races were inherently different, meaning that the black race was inferior to the white one. Many authors have made use of this trope for different purposes, and Zora Neale Hurston was one of them. In her novel Their Eyes Were Watching God, Hurston creates Janie, a mulatta that a priori follows all the characteristics of this type of female character who, however, breaks away from most of them. She overcomes all stereotypes and prejudices, those imposed on her because of her condition of interracial offspring, and is able to take charge of her own life and challenge all these impositions feeling closer to her blackness and celebrating and empowering her female identity. In this vein, storytelling becomes the liberating force that helps her do so. It will become the tool that will enable her to ignore the need of passing as a white person and provide her with the opportunity to connect with her real identity and so feel free and happy, breaking with the tragic destiny of mulatta characters.
Keywords: storytelling, tragic mulatta, blackness, Hurston.
Evaluation of the contralateral ear in patients with unilateral chronic otitis media
Authors: Pardhi Krupal A. , Pathak Netra A. , Shinde Kiran J. 
Published: October 2019

<p class="abstract"><strong>Background:</strong> Unilateral chronic otitis media (COM) is a condition likely to affect the other side also caused by various etiological factors. If diagnosed and intervened in time, the progression of the disease can be prevented and ear can be protected from various sequelae. Hence, it is important to assess and evaluate the contralateral ear (CLE) completely.</p><p class="abstract"><strong>Methods:</strong> A prospective study of 12 months was conducted in the Otorhinolaryngology department, enrolling 80 patients with unilateral chronic otitis media. The CLE defined as the asymptomatic ear without ear discharge or any other complaints. Otoscopy, pure tone audiometry, tympanometry and X-ray mastoid done on patients. The results were recorded and analysed. </p><p class="abstract"><strong>Results:</strong> On otoscopic findings 76.36% patients in mucosal and 88% patients in squamosal showed abnormalities in CLE. Pure tone audiometry (PTA) showed 75% patients had hearing loss in CLE 46.25% conductive hearing loss (HL), 11.25% sensorineural HL and 17.5% mixed HL in CLE. In squamosal type of COM 76% patients had hearing impairment as compared to mucosal type 74.54%. In tympanometry findings 58.75% patients had type B curve in CLE. Radiographic finding of CLE showed sclerotic mastoid air cells 32% in squamosal and 9.09% in mucosal type.</p><p class="abstract"><strong>Conclusions:</strong> Approximately 80% patients with unilateral COM have abnormal ear findings in CLE. Squamosal type of unilateral COM had more chances of abnormalities in CLE. In this study results showed that the CLE can also be affected in unilateral COM.</p>
INCREASED FLUID INTAKE IN PATIENTS WITH CHRONIC KIDNEY DISEASE UNDERGOING HEMODIALYSIS
Authors: Agustina Rismia , Setiawati Eka , Pangestika Ghina , Hayatunnisa Nor Hayatunnisa , Apriani Rosina , Munawarah Siti , Asmadiannor Asmadiannor 
Published: October 2019

Introduction: Some of the main nursing problems that arise in patients with chronic kidney failure undergoing hemodialysis are problems with excess fluid volume.The aim of this study was to describe increased fluid intake in patients with chronic kidney disease undergoing hemodialysis at Ulin General Hospital of Banjarmasin.Methods: This was a descriptive cross sectional study. 80 respondents were taken using consecutive sampling. The instruments used in this study were questionnaire of demographic, knowledge, attitude, family support, involvement of health workers and Inter-Dialytic Weight Gain (IDWG) calculation sheets.Results: The results showed that the majority of respondents were women (53.8%), the education of respondents was high school (28.8%), the average age of respondents was 48.19 years old, most respondents had been undergoing hemodialysis for less than 12 months (57.5%), the frequency of hemodialysis was 2 times each week (93.8%), the level of knowledge was good (42.5%) and moderate (42.5%), the family support was good (86.3%), the attitude was positive (55%), the involvement of health workers was good (60%), and the majority of respondents had moderate IDWG criteria (47.5%).Conclusion: Almost half of patients with chronic kidney disease who were undergoing hemodialysis at Ulin General Hospital of Banjarmasin had moderate IDWG. Further study is needed to investigate related factors of excessive fluid intake in patients undergoing hemodialysis.
Control of Fusarium Disease in Onion with Plant Growth Promoting Rhizobacteria (PGPR) and Mycorrhizae and Its Effect on Growth and Yield of Onion
Authors: Salamiah Salamiah , Ciptady Muhammad Anton , Nisa Chatimatun 
Published: October 2019

<p>The productivity of onion in Indonesia is generally low due to fusarium wilt disease. Biological controls can be applied using PGPR and Mycorrhizae. The purpose of this research was understand the interaction between PGPR and Mycorrhizal inoculation against fusarium wilt intensity as well as the growth and yield of onions. The isolation of <em>Fusarium oxysporum</em> f.sp <em>cepae</em> and PGPR, followed by the tests of PGPR inhibition ability, phosphate solvent and HCN compound productivity. The method used in the field was a completely randomized design (CRD) with 2 replications. Results showed that the combination of PGPR and mycorrhizae as a whole was unable to suppress <em>Fusarium</em> wilt disease, but had significant effect to postpone the incubation period (26,19 days after inoculation) and increase the growth and yield of onion compared to the onion plants infected with <em>Fusarium</em> but without the combined treatment of PGPR and mycorrhizae and the PGPR treatment and mycorrhizal treatment as single treatments; the application of mycorrhizae as the single factor had a very significant effect on the number of bulbs, but had no significant effect on the inhibition of fusarium wilt intensity as well as the growth and yield of onions.</p>
Application of the Composite Hydrotalcite (Mg/Al)/Chitosan as Adsorbent for the Treatment of Raw Water of Municipal Waterworks PDAM Bandarmasih
Authors: Ramadhan Maulana Wahyu Noor , Irawan Chairul , Wijayanti Hesti , Elma Muthia 
Published: October 2019

Research has been carried out about raw water treatment of PDAM Bandarmasih by hydrotalcite (Mg/Al) + chitosan (shell of haruan and papuyu fish) adsorbent reviews of decreasing dye value (PtCo), iron (Fe), and turbidity. This research intended to produce drinking water from utilization of fish shell that were still underutilized into chitosan to be matched with hydrotalcite (Mg/Al) with variations of 1, 2 and 3 grams with a duration of 24 hours. The results showed that the decrease in dyestuff value were 96.78%, 95.03% and 92.98%. Persentage decrease in iron (Fe) were 94.38%, 93.78 and 91.87% and percent of turbidity reduction were 97.98%, 79.76% and 76.56%. Best decrease in variations of hydrotalcite (Mg/Al) + chitosan was 1 gram for a duration of 24 hours which resulted in a decrease in dyestuff, iron and turbidity of 11 PtCo, 0.047 mg/L, 0.76 NTU where the results were appropriate in the drinking water requirements in accordance with the Regulation of the Minister of Health of the Republic of Indonesia no:492/MENKES/PES/IV/2010.
Assisted History Matching for Reservoir Simulation Models
Authors: Syrtlanov Vil , Golovatskiy Yury , Ishimov Ivan , Mezhnova Natalia 
Published: October 2019

Реɜюмe
The paper presents assisted history matching methods for the preparation and modification of the simulation model parameters (absolute permeability, relative permeability, etc.)). The proposed approaches allow both to speed up the history matching process and improve the accuracy of the simulation results.
A Model To Simulate Matrix-Acid Stimulation for Wells in Dolomite Reservoirs with Vugs and Natural Fractures
Authors: Ali Mahmoud T. , Ezzat Ahmed A. , Nasr-El-Din Hisham A. 
Published: October 2019

SummaryDesigning matrix-acid stimulation treatments in vuggy and naturally fractured carbonate reservoirs is a challenging problem in the petroleum industry. It is often difficult to physically model this process, and current mathematical models do not consider vugs or fractures. There is a significant gap in the literature for models that design and evaluate matrix-acid stimulation in vuggy and naturally fractured carbonate reservoirs. The objective of this work is to develop a new model to simulate matrix acidizing under field conditions in vuggy and naturally fractured carbonates.To obtain accurate and reliable simulation parameters, acidizing coreflood experiments were modeled using a reactive-flow simulator. A 3D radial field-scale model was used to study the flow of acid in the presence of vugs (pore spaces that are significantly larger than grains) and natural fractures (breaks in the reservoir that were formed naturally by tectonic events). The vugs’ size and distribution effects on acid propagation were studied under field conditions. The fracture length, conductivity, and orientation, and the number of fractures in the formation, were studied by the radial model. The results of the numerical simulation were used to construct Gaussian-process (GP)-based surrogate models for predicting acid propagation in vuggy and naturally fractured carbonates.Finally, the acid propagation in vuggy/naturally fractured carbonates was evaluated, as well.The simulation results of vuggy carbonates show that the presence of vugs in carbonates results in faster and deeper acid propagation in the formation when compared with homogeneous reservoirs at injection velocities lower than 8×10–4 m/s. Results also revealed that the size and density of the vugs have a significant impact on acid consumption and the overall performance of the acid treatment. The output of the fracture model illustrates that under field conditions, fracture orientations do not affect the acid-propagation velocity. The acid does not touch all of the fractures around the well. The GP model predictions have an accuracy of approximately 90% for both vuggy and naturally fractured cases. The vuggy/naturally fractured model simulations reveal that fractures are the main reason behind the fast acid propagation in these highly heterogeneous reservoirs.
Chicken adaptive response to low energy diet: main role of the hypothalamic lipid metabolism revealed by a phenotypic and multi-tissue transcriptomic approach
Authors: Jehl Frédéric , Désert Colette , Klopp Christophe , Brenet Marine , Rau Andrea , Leroux Sophie , Boutin Morgane , Lagoutte Laetitia , Muret Kévin , Blum Yuna , Esqu Diane , Gourichon David , Burlot Thierry , Collin Anne , Pitel Frédérique , Benani Alexandre , Zerjal Tatiana , Lagarrigue Sandrine 
Published: October 2019

Abstract
Background
Production conditions of layer chicken can vary in terms of temperature or diet energy content compared to the controlled environment where pure-bred selection was undertaken. The aim of this study was to better understand the effect of a 15%-energy depleted diet on egg-production, energy homeostasis and metabolism via a multi-tissue transcriptomic analysis. Study was designed to compare effects of the nutritional intervention in two layer chicken lines divergently selected for residual feed intake.
Results
Chicken significantly increased their feed intake and decreased their abdominal adipose tissue weight in response to the low-energy diet, whereas their egg-production was unchanged. For each production trait, no significant interaction was observed between diet and line. Moreover, the low energy diet had no effect on adipose tissue and liver transcriptomes. By contrast, the nutritional challenge affected the blood transcriptome and, more severely, the hypothalamus transcriptome which displayed 2700 differentially expressed genes. In this tissue, the low-energy diet lead to an over-expression of genes related to endocannabinoid signaling (CN1R, NAPE-PLD) known to regulate feed intake, and to genes related to polyunsaturated fatty acids synthesis (FADS1, ELOVL5 and FADS2) such as the arachidonic acid which is a precursor of anandamide, a key endocannabinoid. A possible regulatory role of NR1H3 (alias LXRα) has been associated to these transcriptional changes. The low-energy diet further affected brain plasticity-related genes involved in the cholesterol synthesis and in the synaptic activity, revealing a link between nutrition and brain plasticity. It also upregulated genes related to protein synthesis, mitochondrial oxidative phosphorylation and fatty acid oxidation in the hypothalamus, suggesting reorganization in nutrient utilization and biological synthesis in this brain area.
Conclusions
We observed a complex transcriptome modulation in the hypothalamus of chicken in response to low-energy diet suggesting numerous changes in synaptic plasticity, endocannabinoid regulation, neurotransmission, lipid metabolism, mitochondrial activity and protein synthesis. This global transcriptomic reprogramming could explain the adaptive behavioral response (i.e. increase of feed intake) of the animals to the low-energy content of the diet.
Detection and application of genome-wide variations in peach for association and genetic relationship analysis
Authors: Guan Liping , Cao ke , Li yong , guo jian , xu qiang , Wang Lirong 
Published: October 2019

Abstract
Abstract
Background: Peach (Prunus persica L.) is a diploid species and model plant of the Rosaceae family. In the past decade, significant progress has been made in peach genetic research via DNA markers, but the number of these markers remains limited.
Results: In this study, we performed a genome-wide DNA markers detection based on sequencing data of six distantly related peach accessions. A total of 650,693~1,053,547 single nucleotide polymorphisms (SNPs), 114,227~178,968 small insertion/deletions (InDels), 8,386~12,298 structure variants (SVs), 2,111~2,581 copy number variants (CNVs) and 229,357~346,940 simple sequence repeats (SSRs) were detected and annotated. To demonstrate the application of DNA markers, 944 SNPs were filtered for association study of fruit ripening time and 15 highly polymorphic SSRs were selected to analyze the genetic relationship among 221 accessions.
Conclusions: The results showed that the use of high-throughput sequencing to develop DNA markers is fast and effective. Comprehensive identification of DNA markers, including SVs and SSRs, would be of benefit to genetic diversity evaluation, genetic mapping, and molecular breeding of peach.