bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomechanical Effect of L4–L5 Intervertebral Disc Degeneration on the Lower Lumbar Spine: A Finite Element Study
Authors: Cai Xin‐yi , Sun Meng‐si , Huang Yun‐peng , Liu Zi‐xuan , Liu Chun‐jie , Du Cheng‐fei , Yang Qiang 
Published: June 2020

ObjectiveTo ascertain the biomechanical effects of a degenerated L4–L5 segment on the lower lumbar spine through a comprehensive simulation of disc degeneration.MethodsA three‐dimensional nonlinear finite element model of a normal L3–S1 lumbar spine was constructed and validated. This normal model was then modified such that three degenerated models with different degrees of degeneration (mild, moderate, or severe) at the L4–L5 level were constructed. While experiencing a follower compressive load (500 N), hybrid moment loads were applied to all models to determine range of motion (ROM), intradiscal pressure (IDP), maximum von Mises stress in the annulus, maximum shear stress in the annulus, and facet joint force.ResultsAs the degree of disc degeneration increased, the ROM of the L4–L5 degenerated segment declined dramatically in all postures (flexion: 5.79°–1.91°; extension: 5.53°–2.62°; right lateral bending: 4.47°–1.46°; left lateral bending: 4.86°–1.61°; right axial rotation: 2.69°–0.74°; left axial rotation: 2.69°–0.74°), while the ROM in adjacent segments increased (1.88°–8.19°). The largest percent decrease in motion of the L4–L5 segment due to disc degeneration was in right axial rotation (75%), left axial rotation (69%), flexion (67%), right lateral bending (67%), left lateral bending right (67%), and extension (53%). The change in the trend of the IDP was the same as that of the ROM. Specifically, the IDP decreased (flexion: 0.592–0.09 MPa; extension: 0.678–0.334 MPa; right lateral bending: 0.498–0.205 MPa; left lateral bending: 0.523–0.272 MPa; right axial rotation: 0.535–0.246 MPa; left axial rotation: 0.53–0.266 MPa) in the L4–L5 segment, while the IDP in adjacent segments increased (0.511–0.789 MPa). The maximum von Mises stress and maximum shear stress of the annulus in whole lumbar spine segments increased (L4–L5 segment: 0.413–2.626 MPa and 0.412–2.783 MPa, respectively; adjacent segment of L4–L5: 0.356–1.493 MPa and 0.359–1.718 MPa, respectively) as degeneration of the disc progressively increased. There was no apparent regularity in facet joint force in the degenerated segment as the degree of disc degeneration increased. Nevertheless, facet joint forces in adjacent healthy segments increased as the degree of disc degeneration increased (extension: 49.7–295.3 N; lateral bending: 3.5–171.2 N; axial rotation: 140.2–258.8 N).ConclusionDegenerated discs caused changes in the motion and loading pattern of the degenerated segments and adjacent normal segments. The abnormal load and motion in the degenerated models risked accelerating degeneration in the adjacent normal segments. In addition, accurate simulation of degenerated facet joints is essential for predicting changes in facet joint loads following disc degeneration.
P3 amplitude reductions are associated with shared variance between internalizing and externalizing psychopathology
Authors: Bernat Edward M. , Ellis Jessica S. , Bachman Matthew D. , Hicks Brian M. 
Published: June 2020

AbstractP3 amplitude reductions, commonly elicited in oddball paradigms, have been associated with both internalizing (e.g., depression and anxiety) and externalizing problems (e.g., substance use, aggression, and impulsivity). Recent factor analytic models have focused on the shared variance between internalizing and externalizing problems as a potentially important separable psychopathology construct (a general psychopathology factor, or p‐factor). To assess neurophysiological markers of this shared variance, we examined P3 amplitude to target and novel stimuli in an undergraduate sample with a range of internalizing and externalizing problems. Participants (N = 125) completed a rotated heads visual oddball paradigm, with IAPS pictures serving as infrequent novel stimuli. Results replicated P3 amplitude reduction relative to both target and novel stimuli separately for internalizing and externalizing problems, and found that the shared variance across internalizing and externalizing was significantly related to lower P3 amplitude to novels, targets, and a factor score of target and novel P3 measures. The present results are consistent with the interpretation that a general or shared problem behavior factor accounts for much of the associations between reduced P3 amplitude and internalizing and externalizing problems.
Contractile rate of force development after anterior cruciate ligament reconstruction—a comprehensive review and meta‐analysis
Authors: Turpeinen Juha‐Tapio , Freitas Tomás T. , Rubio‐Arias Jacobo Ángel , Jordan Matthew J. , Aagaard Per 
Published: June 2020

Study designComprehensive review and meta‐analysis.BackgroundThe recovery in rapid force production measured as the rate of force development (RFD) is not clear after anterior cruciate ligament reconstruction (ACLR).ObjectivesTo evaluate (a) time‐course change of between‐limb asymmetries in isometric knee extension/flexion RFD in individuals post‐ACLR and (b) differences in RFD between individuals post‐ACLR and healthy controls.MethodsA literature search of Web of Science, SPORTDiscus, PubMed‐MEDLINE, and ScienceDirect identified 10 eligible studies (n = 246) assessing RFD after ACLR.ResultsStandard mean difference (SMD) for early‐phase (<100 ms) knee extensor RFD was −1.07 (95% CI: −1.46, −0.68) when comparing ACLR vs uninjured limb, while SMD for late‐phase (≥100 ms) RFD was −0.85 (95 CI%: −1.27, −0.42). SMD for early‐ and late‐phase knee flexor RFD was −0.74 (95% CI: −1.19, −0.29) and −0.79 (95% CI: −1.19, −0.39), respectively. Comparing ACLR limbs to uninjured controls, knee extensor SMD for early‐ and late‐phase RFD was −1.42 (95% CI: −2.10, −0.73) and 1.09 (95% CI: −1.81, −0.38). For the knee flexors, SMD for early‐ and late‐phase RFD was −0.78 (95% CI: −1.96, −0.39) and −1.14 (95% CI: −1.60, −0.67).ConclusionsAnterior cruciate ligament reconstruction limbs demonstrated sustained post‐surgical suppression in RFD capacity for the knee extensors/flexors compared to the contralateral limb as well as to healthy controls. Monitoring of RFD should be considered throughout rehabilitation and return to sport (RTS) after ACLR to assess the effectiveness of post‐operative rehabilitation. Post‐surgical ACLR rehabilitation should include training interventions to enhance RFD.
Isolated pulmonary fusariosis caused by Neocosmospora pseudensiformis in a liver transplant recipient: A case report and review of the literature
Authors: Yamasmith Eakkawit , Chongtrakool Piriyaporn , Chayakulkeeree Methee 
Published: June 2020

AbstractNeocosmospora pseudensiformis (formerly Fusarium pseudensiforme) is a hyaline mold in the Fusarium solani species complex that has been changed to the genus Neocosmospora. Invasive fusariosis is a rare fungal infection in solid organ transplantation. The most commonly reported manifestation of invasive fusariosis in this setting is localized cutaneous fusariosis. Here, we present the first case report of isolated N pseudensiformis pulmonary infection in a patient with non‐alcoholic steatohepatitis cirrhosis who underwent orthotopic liver transplantation. A 67‐year‐old Thai woman developed acute graft rejection, dyspnea, and pulmonary consolidation 6 months after liver transplantation. N pseudensiformis was isolated from her sputum, and her clinical symptoms were improved with voriconazole treatment. However, she succumbed to Acinetobacter baumannii hospital‐acquired pneumonia and acute coronary syndrome with cardiogenic shock after 10 days of treatment.
Early experience with transfusing low titer group O whole blood in the pre‐hospital setting in Israel
Authors: Nadler Roy , Tsur Avishai M. , Yazer Mark H. , Shinar Eilat , Moshe Tzadok , Benov Avi , Glassberg Elon , Epstein Danny , Chen Jacob 
Published: June 2020

BACKGROUNDThe Israeli Defense Force Medical Corps (IDF‐MC) recently implemented the use of low titer group O whole blood (LTOWB) in the airborne combat search and rescue unit (CSAR) for both military and civilian patients during transport to definitive care. LTOWB is preferentially used by the CSAR instead of red blood cell units and freeze‐dried plasma (FDP) for patients with signs of hemorrhagic shock. Ten percent of group O donors were eligible to donate LTOWB as they had anti‐A and ‐B IgM titers of <50.METHODSAll patients treated by CSAR providers with LTOWB between July 2018 and June 2019 were included.RESULTSBetween July 2018 and June 2019, eight patients have received 10 units of LTOWB. All patients suffered blunt injuries, 6 out of 8 (75%) of whom were due to motor vehicle accidents. Four patients (4 out of 8, 50%) received a single LTOWB unit, two patients (2 out of 8, 25%) received two units. Two pediatric patients received fewer than one unit of LTOWB. Median (range) heart rate was 130 (30‐150) bpm, median systolic blood pressure was 107 (80‐124) mmHg, and median Glasgow coma scale was 8 (on a scale of 3‐15). For four (4 out of 8, 50%) patients, LTOWB was the only blood product used for volume resuscitation. All six adult patients were treated with 1 g of tranexamic acid at the point of injury.CONCLUSIONSThe CSAR has successfully implemented a LTOWB program for the pre‐hospital treatment of bleeding patients, and as its experience grows this product will be made available to other units and in civilian hospitals.
Performance characteristics of thromboelastometry assays using incompletely filled and prolonged stored samples
Authors: Paarup Helene M. , Rasmussen Mads H. , Yazer Mark H. , Sprogøe Ulrik 
Published: June 2020

BACKGROUNDThromboelastometry (TEM) is often used to guide transfusion therapy in patients with massive bleeding. The effect of testing incompletely filled samples and those stored for a prolonged time at 4°C was investigated.METHODSWhole blood samples were collected from 15 healthy blood donors and were pooled according to ABO group. From these pools, aliquots were taken and diluted to produce final whole blood:citrate buffer ratios ranging from 90:10 (fully filled sample) to 40:60 (extremely under filled samples). These samples were then tested by EXTEM, INTEM, and FIBTEM on calibrated ROTEM delta machines. Separately, the four samples at 90:10 dilution were kept at 4°C for 16‐20 hours and then retested on the ROTEM machines.RESULTSAll of the samples at the 90:10 and 80:20 (half‐filled sample) whole blood:citrate buffer dilutions demonstrated ROTEM parameters within their respective reference ranges, although the samples from the 80:20 dilution tended to demonstrate slightly longer or slower times, depending on each ROTEM parameter, compared to the completely filled samples. All of the samples with more dilute whole blood to citrate buffer ratios (i.e., 70:30 to 40:60) yielded abnormal TEM results. The TEM results for the 90:10 dilution samples exposed to 16‐20 hours of storage at 4°C were within the reference intervals.CONCLUSIONCompletely and half‐filled samples, and completely filled samples after prolonged cold storage, produced normal ROTEM results. Tubes that are less than half‐filled should not be used for ROTEM testing.
Use of Specialized Pro‐Resolving Mediators to Alleviate Cold Platelet Storage Lesion
Authors: Reddoch‐Cardenas Kristin M. , Sharma Umang , Salgado Christi L. , Cantu Carolina , Darlington Daniel N. , Pidcoke Heather F. , Bynum James A. , Cap Andrew P. 
Published: June 2020

BACKGROUNDCold‐stored platelets are an attractive option for treatment of actively bleeding patients due to a reduced risk of septic complications and preserved hemostatic function compared to conventional room temperature–stored platelets. However, refrigeration causes increased platelet activation and aggregate formation. Specialized pro‐resolving mediators (SPMs), cell signaling mediators biosynthesized from essential fatty acids, have been shown to modulate platelet function and activation. In this study, we sought to determine if SPMs could be used to inhibit cold‐stored platelet activation.METHODSPlatelets were collected from healthy donors (n = 4‐7) and treated with SPMs (resolvin E1 [RvE1], maresin 1 [MaR1], and resolvin D2 [RvD2]) or vehicle (VEH; 0.1% EtOH). Platelets were stored without agitation in the cold and assayed on Days 0 and 7 of storage for platelet activation levels using flow cytometry, platelet count, aggregation response using impedance aggregometry, and nucleotide content using mass spectrometry.RESULTSCompared to VEH, SPM treatment inhibited GPIb shedding (all compounds), significantly reduced both PS exposure and activation of GPIIb/IIIa receptor (RvD2, MaR1), and preserved aggregation response to TRAP (RvD2, MaR1) after 7 days of storage. Similar to untreated cold‐stored platelets, SPM‐treated samples did not preserve platelet counts or block the release of P‐Selectin. Nucleotide content was unaffected by SPM treatment in cold‐stored platelets.CONCLUSIONSSPM treatment, particularly Mar1 and RvD2, led to reduced platelet activation and preserved platelet function after 7 days of storage in the cold. Future work is warranted to better elucidate the mechanism of action of SPMs on cold platelet function and activation.
Endogenous cyclical corporate tax burden in China: The role of tax quotas and growth targets
Authors: Fang Hongsheng , He Minyuan , Dang Dandan , Zhang Jun 
Published: June 2020

AbstractUsing data from China Annual Survey of Industrial Firms and addressing potential endogeneity problem, we find that corporate tax burden in China is procyclical during recessions and countercyclical during booms. The cyclicality is stronger for enterprises whose corporate income taxes are levied by Local Tax Bureau (LTB). Procyclicality of corporate tax burden during recessions is larger for enterprises located in county, non‐state‐owned enterprises (non‐SOEs), non‐high‐tech enterprises and large‐medium enterprises. Furthermore, tax quotas and growth targets of local governments enhance procyclicality during recessions and the countercyclicality of corporate tax burden during booms. Tax collection and government spending are important channels through which tax quotas and growth targets affect the cyclicality of corporate tax burden, respectively. This paper provides important policy implications for China during economic recessions.
Efficacy of long‐term topical flurbiprofen in limiting lens capsule opacities following phacoemulsification in dogs
Authors: Newbold Georgina M. , Chen Thomas , Ward Daniel A. , Hendrix Diane V. H. 
Published: June 2020

AbstractObjectiveTo assess lens capsule opacity (LCO) following phacoemulsification in dogs receiving long‐term topical ophthalmic flurbiprofen sodium 0.03%.Animal studiedTwenty‐five client owned dogs undergoing phacoemulsification surgery for either diabetic or nondiabetic cataracts.MethodsProspective, randomized, masked clinical study assessing two groups of dogs for twelve months following phacoemulsification. All dogs underwent a complete eye examination and were photographed at each visit, beginning three weeks post‐surgery, and repeated at 2, 3, 6, and 12 months post‐surgery. Post‐operative treatment protocols were similar for both groups, except that Group F received topical flurbiprofen once daily for 12 months and Group A received artificial tears once daily for 12 months. Digital photographs were analyzed for LCO using a subjective grading scale (0‐4). The change in capsular opacities from 3 weeks to 12 months post‐surgery was evaluated for each dog, and the groups were compared.ResultsThere were 25 dogs evaluated post‐phacoemulsification at each designated time point of the study. There were 12 dogs in Group A and 13 dogs in Group F. There was no significant statistical difference in LCO score between Groups A and F at baseline (3 weeks post‐surgery), 6 months post‐surgery, or 12 months post‐surgery. Scores did not change significantly from baseline to 12 months within or between groups.ConclusionsTopical ophthalmic flurbiprofen sodium 0.03% solution applied once daily for 12 months following phacoemulsification does not appear to lead to a decrease in LCO formation as compared to artificial tears control.
Provenance changes across the mid-Cretaceous unconformity in basins of northeastern China: Evidence for an integrated paleolake system and tectonic transformation
Authors: Li Shuang-Qing , He Song , Chen Fukun 
Published: June 2020

Abstract
Detrital zircon U-Pb dating and whole-rock Nd isotopic analyses were carried out on selected stratigraphic horizons across a major unconformity between synrift and postrift stages in the Songliao Basin and Dasanjiang basin group of NE China to constrain the crustal evolution of the source area providing detritus into these basins. The strata underlying the mid-Cretaceous unconformity in the Songliao Basin show regionally distinct detrital zircon age populations and Nd isotopic compositions, which generally are characterized by Phanerozoic age peaks and relatively depleted Nd isotopic compositions, indicating derivation from nearby highlands. In contrast, the overlying strata are dominated by Proterozoic zircon ages and enriched Nd isotopic compositions, which imply that the provenance source region shifted to the northern part of the North China craton. A coeval provenance change also affected the sedimentary architecture in the eastern Dasanjiang basin group, marking the migration of erosion centers from west to east. The contribution from Lesser Xing’an–Zhangguangcai ranges was pronounced during deposition of synrift strata but became negligible afterward in the Songliao and Dasanjiang areas, which is consistent with both basin complexes temporarily forming an extensive lake system during the early Late Cretaceous. This paleolake was likely responsible for transgressive events recorded in the Late Cretaceous strata of basins in NE China. Combining observations from seismic reflection profiles and the stratigraphic record of neighboring intracontinental sedimentary basins as well as widespread contemporaneous exhumation and denudation events, we suggest that the provenance variation in basin strata was controlled by large-scale tectonic transitions in East Asia. The switch from extension to contraction during the mid-Cretaceous is attributed to the docking of the Okhotomorsk block along the East Asian continental margin. The resulting lithospheric buckling might have been responsible for reshaping the basin-and-range configuration in NE Asia.
Improved diabetes control among low-income Mexican Americans through community-clinical interventions: results of an RCT
Authors: Reininger Belinda M , Lee MinJae , Hessabi Manouchehr , Mitchell-Bennett Lisa A , Sifuentes Maribel R , Guerra Jose A , Ayala Ciara D , Xu Tianlin , Polletta Valerie , Flynn Amy , Rahbar Mohammad H 
Published: June 2020

IntroductionThis randomized controlled trial investigated community-clinical intervention strategies for a Mexican American population who had not demonstrated control of their diabetes. We tested a control program (Salud y Vida 1.0) supporting diabetes management versus an enhanced version (Salud y Vida 2.0) for reductions in HbA1c at 12 months.Research design and methodsAdults with uncontrolled diabetes (n=353) were enrolled if they had an HbA1c≥9.0% during a program or doctor’s visit between 6 and 36 months of their receipt of SyV 1.0 services, were patients at one of two clinics in local counties, and had an HbA1c≥8.0% at SyV 2.0 baseline enrollment. The control and intervention arms were coordinated by community health workers and the intervention arm included the control program enhanced with medication therapy management; behavioral health services; peer-led support groups; and additional community-based lifestyle programs also open to the family.ResultsAt 12 months, both study arms improved HbA1c (mean, (CI), Control (−0.47 (-0.74 to –0.20)) and intervention (−0.48 (-0.76 to –0.19)). The intervention group maintained HbA1c levels after month 6, whereas control group HbA1c levels slightly increased (adjusted mean from 9.83% at month 6%–9.90% at month 12). Also, HbA1c was examined by level of participant engagement. The high engagement group showed a decreasing trend over the study period, while control and lower engagement groups failed to maintain HbA1c levels at month 12.ConclusionsImproved HbA1c was found among a population that had not demonstrated diabetes management prior; however, mean HbA1c values were above clinical guideline recommendations. The randomized control trial findings provide additional evidence that extended time and intervention supports may be needed for populations experiencing inequities in social determinants of health.Trial registration numberNCT04035395.
Photobiomodulation therapy associated with supervised therapeutic exercises for people with knee osteoarthritis: a randomised controlled trial protocol
Authors: S Jorge Ana E , O Dantas Lucas , M S Serrão Paula R , Alburquerque-Sendín Francisco , Salvini Tania F 
Published: June 2020

BackgroundPhysical exercise, a cornerstone of the conservative management of knee osteoarthritis (KOA), is exhaustively recommended by important clinical guidelines. A strength therapeutic exercise program (STEP) relieves pain, improves physical function and ultimately ameliorates quality of life (QoL). Furthermore, photobiomodulation (PBM) has been used as an adjunct treatment for people with KOA; however, there are still controversial recommendations regarding its use on this population. Thus, we hypothesised that PBM, when associated with a STEP protocol on patients with KOA, could induce better clinical outcomes than a STEP protocol alone.Methods and analysisThe study is a 6-month triple-blind placebo-controlled randomised clinical trial with intention-to-treat analysis. The trial will include 120 people with clinic and radiographic signs of KOA. The intervention consists of a supervised STEP and PBM protocols conducted over an 8-week intervention period. Assessments are performed at baseline, right after treatment, and 3-month and 6-month follow-up periods. The primary clinical outcome is pain intensity according to a 10 cm Visual Analogue Scale. Secondary outcomes are the global Western Ontario & McMaster Universities Osteoarthritis Index; QoL assessed by the 36-item Short-Form health survey questionnaire; and performance-based physical parameters assessed by the 30 s chair stand test; the stair climb test; and the 40 m fast-paced walk test.Ethics and disseminationThe trial was approved by the Human Research Ethics Committee of the Federal University of São Carlos, São Paulo, Brazil (REC no 2.016.122). Results will be published in peer-reviewed journals.Trial registration numberBrazilian Clinical Trials Registry (U1111-1215-6510).
Cutting performance comparison of two different diamond segments used in frame saw for granite
Authors: Sun Qin , Zhang Jinsheng 
Published: June 2020

Blades with concave segments and multi-layered segments were employed to cut large-sized granite (size: 2000 mm × 2000 mm × 2000 mm) using a diamond frame saw, which can accommodate 80–120 blades (size: 4000 mm × 180 mm × 3.5 mm). Cutting force was determined by a Kistler dynamometer, and diamond segment wear was examined by scanning electron microscopy and Keyence microscopy. Sawing performance was evaluated based on slab quality, radial wear, cutting force (force ratio), and slab production rate. Compared with the blade with multi-layered segments, experimental results showed that the blade with concave segments produced better slab quality; lower cutting forces, force ratio (normal force/horizontal force), and radial wear (tool consumption); and higher slab production rate. Experiments indicate that blades with concave diamond segments are more suitable for the diamond frame saw to cut granite.