bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regularity “in Large” for the 3DSalmon’s Planetary Geostrophic Model of Ocean Dynamics
Authors: Cao Chongsheng , Titi Edriss S. 
Published: January 2020

AbstractIt is well known, by now, that the three-dimensional non-viscous planetary geostrophic model, with vertical hydrostatic balance and horizontal Rayleigh friction/damping, coupled to the heat diffusion and transport, is mathematically ill-posed. This is because the no-normal flow physical boundary condition implicitly produces an additional boundary condition for the temperature at the lateral boundary. This additional boundary condition is different, because of the Coriolis forcing term, than the no-heat-flux physical boundary condition. Consequently, the second order parabolic heat equation is over-determined with two different boundary conditions. In a previous work we proposed one remedy to this problem by introducing a fourth-order artificial hyper-diffusion to the heat transport equation and proved global regularity for the proposed model. A shortcoming of this higher-oder diffusion is the loss of the maximum/minimum principle for the heat equation. Another remedy for this problem was suggested by R. Salmon by introducing an additional Rayleigh-like friction/damping term for the vertical component of the velocity in the hydrostatic balance equation. In this paper we prove the global, for all time and all initial data, well-posedness of strong solutions to the three-dimensional Salmon’s planetary geostrophic model of ocean dynamics. That is, we show global existence, uniqueness and continuous dependence of the strong solutions on initial data for this model. Unlike the 3D viscous PG model, we are still unable to show the uniqueness of the weak solution. Notably, we also demonstrate in what sense the additional damping term, suggested by Salmon, annihilate the ill-posedness in the original system; consequently, it can be viewed as “regularizing” term that can possibly be used to regularize other related systems.
Determination of relative solids concentration in homogeneous dual component pulp-filler suspension by multi-spectrophotometer
Authors: Niskanen Ilpo , Forsberg Viviane , Zakrisson Daniel , Engberg Birgitta A. , Heikkilä Rauno , Thungström Göran 
Published: January 2020

Abstract
The concentration of fibers and fillers in the pulp suspension is an important parameter in the monitoring process. This paper proposes a versatile optical measurement system to estimate the concentration of a solids mixture in water. The geometry used in a multi-spectrophotometer (MSM) enables the controlled observation of transmission, and forward scattering light from the suspension in the UV-visible spectral range. We have developed the new fibers mixing system which gives a homogenous distribution of the fines and fillers making it possible to increase the reproducibility and accuracy of the measurement. The data analysis is based on the Beer-Lambert law and CIELAB color space equations. The results show that the proposed method is accurate for measuring the fines and filler concentrations in multicomponent suspensions.
Sodium dodecyl sulphate (SDS) residue analysis of foam-formed cellulose-based products
Authors: Viitala Janika , Lappalainen Timo , Järvinen Marjo 
Published: January 2020

AbstractSurfactant residues in foam forming are related to the circulation of surfactant in the foaming process, but they may also affect the properties of the foam-formed product. In this work, residues of an anionic surfactant, sodium dodecyl sulphate (SDS), in foam-formed products were studied. Two different methods were applied for the determination of SDS: ICP-OES (Inductively Coupled Plasma Optical Emission Spectroscopy) and solvent extraction spectrophotometry. The dry matter content of the sample before the drying step has a significant effect on the SDS residue. Another factor that has a significant effect on the SDS residues is the amount of precipitated dodecyl sulphate (DS). It was found that SDS does not degrade in the drying phase and will remain in the salt form in the final product. SDS residue decreased when the temperature of the fibre suspension was increased. Theoretical values for SDS residues were estimated from the original surfactant concentration and the amount of water remaining in the product before the drying phase. When all the surfactant was in soluble form, measured SDS residues were close to the theoretical values, which indicates that SDS was not permanently adsorbed onto softwood cellulose fibres.
Brain energetics, mitochondria, and traumatic brain injury
Authors: Benaroya Haym 
Published: January 2020

Abstract
We review current thinking about, and draw connections between, brain energetics and metabolism, and between mitochondria and traumatic brain injury. Energy is fundamental to proper brain function. Its creation in a useful form for neurons and glia, and consistently in response to the brain’s high energy needs, is critical for physiological pathways. Dysfunction in the mechanisms of energy production is at the center of neurological and neuropsychiatric pathologies. We examine the connections between energetics and mitochondria – the organelle responsible for almost all the energy production in the cell – and how secondary pathologies in traumatic brain injury result from energetic dysfunction. This paper interweaves these topics, a necessity since they are closely coupled, and identifies where there exist a lack of understanding and of data. In addition to summarizing current thinking in these disciplines, our goal is to suggest a framework for the mathematical modeling of mechanisms and pathways based on optimal energetic decisions.
Reducing Unnecessary Testing in Uncomplicated Skin and Soft Tissue Infections: A Quality Improvement Approach
Authors: Lee Begem , Hershey Daniel , Patel Aarti , Pierce Heather , Rhee Kyung E. , Fisher Erin 
Published: January 2020

OBJECTIVES:
Skin and soft tissue infections are common pediatric diagnoses with substantial costs. Recent studies suggest blood cultures are not useful in management of uncomplicated skin and soft tissue infections (uSSTIs). Complete blood cell count, erythrocyte sedimentation rate, and C-reactive protein are also of questionable value. We aimed to decrease these tests by 25% for patients with uSSTIs admitted to the pediatric hospital medicine service within 3 months.

METHODS:
An interdisciplinary team led a quality improvement (QI) project. Baseline assessment included review of the literature and 12 months of medical records. Key stakeholders identified drivers that informed the creation of an electronic order set and development of a pediatric hospital medicine–emergency department collaborative QI project. The primary outcome measure was mean number of tests per patient encounter. Balancing measures included unplanned readmissions and missed diagnoses.

RESULTS:
Our baseline-year rate was 3.4 tests per patient encounter (573 tests and 169 patient encounters). During the intervention year, the rate decreased by 35% to 2.2 tests per patient encounter (286 tests and 130 patient encounters) and was sustained for 14 months postintervention. There were no unplanned readmissions or missed diagnoses for the study period. Order set adherence was 80% (83 out of 104) during the intervention period and sustained at 87% postintervention.

CONCLUSIONS:
Our interdisciplinary team achieved our aim, reducing unnecessary laboratory testing in patients with an uSSTI without patient harm. Awareness of local culture, creation of an order set, defining appropriate patient selection and testing indications, and implementation of a collaborative QI project helped us achieve our aim.
Oral Vitamin K Prophylaxis in Newborns: A Survey of Clinician Opinions and Practices
Authors: Cheng Jessica H. , Loyal Jaspreet , Wood Kelly E. , Kair Laura R. 
Published: January 2020

OBJECTIVES:
The majority of newborns in the United States receive intramuscular (IM) vitamin K for prophylaxis against vitamin K deficiency bleeding (VKDB). Oral vitamin K is less effective than IM vitamin K in preventing VKDB but is widely used in Europe and by some in the United States when parents refuse IM vitamin K for their newborn. Our aim was to assess the practices, opinions, and knowledge of newborn clinicians regarding oral vitamin K prophylaxis when parents refuse IM vitamin K.

METHODS:
We conducted an electronic survey of newborn clinicians from 3 academic medical centers in California, Iowa, and Connecticut. Descriptive statistics and χ2 tests were performed.

RESULTS:
Of 160 newborn clinicians at 3 sites, 110 (69%) completed the survey. Of respondents, 58 (53%) believed the incidence of IM vitamin K refusal is increasing and had prescribed or recommended oral vitamin K at least once. Regarding knowledge, 32 (28%) and 23 (20%) respondents did not know whether oral vitamin K decreases the risk of early- and late-onset VKDB, respectively. There were no significant differences in opinions, knowledge, or practices across institutions or practice settings (NICU, well-newborn nursery, or both) (P &gt; .05).

CONCLUSIONS:
Our study findings suggest that newborn clinicians may lack knowledge about the effectiveness of oral vitamin K in preventing VKDB. More information is needed about oral vitamin K regimens and outcomes of newborns who receive oral vitamin K.
Proportional hazards model under ranked set sampling scheme using censored data of coronary heart disease
Authors: KOYUNCU Nursel , ATA TUTKUN Nihal 
Published: January 2020

The proportional hazards model is one of the most common model for analyzing survival data. Only proportional hazards assumption is required to apply this model. Using appropriate sampling methods is an important part of modelling data and estimation of parameters. In literature there is a few studies based on sampling methods in survival analysis and most of them are related with non-parametric estimations of survival functions, sample size calculation etc. The main innovation of our approach is to examine the sampling methods for the proportional hazards model. This paper describes usage of ranked set sampling design in the proportional hazards model. In order to analyze the performance of our methods, we use a real data and conduct a simulation study. We conclued that ranked set sampling is more efficient than simple random sampling.
Galectin-1 reduces the severity of ulcerative colitis induced by dextran sulfate sodium via suppressing inflammatory and oxidative mediators
Authors: Arda-Pirincci Pelin , Aykol-Celik Guliz 
Published: January 2020

Ulcerative colitis is an inflammatory bowel disease and many people suffers from this disease across the word. Dextran sulfate sodium (DSS) is a synthetic sulfated polysaccharide that is used to produce ulcerative colitis in rodents. Galectin-1 is a β-galactoside binding animal lectin which plays key roles in many biological events. In this study, we investigated the role of galectin-1 on colon morphology, cell proliferation, oxidative stress, anti-oxidant system, inflammatory and anti-inflammatory mediators in the model of experimental ulcerative colitis induced by DSS in mice. C57BL/6 mice were fed orally 3% DSS in their drinking water for 5 days for acute colitis induction. Animals were injected with 1 mg/kg recombinant human galectin-1 for 7 consecutive days. Oral DSS application resulted in colitis injury by causing histopathological changes; an increase in disease activity index (DAI), lipid peroxidation (MDA), myeloperoxidase (MPO) and TNF-α levels; a decrease in body weight, colon length, cell proliferation index, catalase (CAT), glutahione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities, gluathione (GSH) and IL-10 levels. However, treatment with galectin-1 prevented DSS-induced colitis injury through the reduction of DAI, MDA, MPO and TNF-α levels, and the increase of body weight, colon length, cell proliferation, antioxidant enzymes activities, GSH and IL-10 levels. As a result, this study showed that galectin-1 has proliferative, anti-oxidant, anti-inflammatory, and cytoprotective effects against DSS-induced colitis in mice. In addition, galectin-1 reduces the severity of ulcerative colitis via suppressing inflammatory and oxidative mediators.
The Use of Resinous Infiltrants for the Management of Incipient Carious Lesions: a Literature Review
Authors: Ferreira Jéssica Delazari , Flor-Ribeiro Mariana Dias , Marchi Giselle Maria , Pazinatto Flávia Bittencourt 
Published: January 2020

AbstractThe objective of this work was to analyze scientific evidence from a literature review pertaining to the effectiveness of resinous infiltrants for minimally invasive treatment of incipient carious lesions. Studies published between 2002 and 2019 were queried from the following databases: Capes, PubMed, Medline, BBO, Lilacs and SciELO. The search keywords included "Dental Caries", "Tooth Remineralization", "Dental Leakage". Most of the studies found resin-infiltrating treatment to be a viable option for the minimally invasive treatment of incipient carious lesions; this treatment was able to fulfill the primary expected effects: inhibition of carious progression and the lesions esthetic improvement. However, some issues need to be clarified to improve the safety of this treatment because it can be recommended in clinical practice. In conclusion, the use of resinous infiltrants has been reported as promising for the treatment of incipient carious lesions. However, there is a need for long-term studies to confirm the effectiveness of this treatment to determine its applicability for clinical use. Keywords: Dental Caries. Dental Leakage. Tooth Remineralization. ResumoO objetivo desse trabalho foi analisar evidências científicas, por meio de uma revisão de literatura, sobre a eficácia do uso de infiltrantes resinosos para o tratamento minimamente invasivo de lesões cariosas incipientes. A seleção do material literário utilizado foi realizada por pesquisa sobre o tema nas bases de dados: portal de periódicos Capes, PubMed, Medline, BBO, Lilacs e SciELO, abrangendo prioritariamente, o período de 2002 a 2019. Para busca nas bases de dados foram utilizadas palavras-chave como “Cárie Dentária”, “Remineralização Dentária”, “Infiltração Dentária”, assim como suas correspondentes na língua inglesa. A maioria dos estudos encontrados aponta o tratamento infiltrante resinoso como uma opção viável para o tratamento minimamente invasivo de lesões cariosas incipientes sendo capaz de cumprir os principais efeitos esperados: inibição da progressão cariosa e melhoria estética das lesões. Entretanto, alguns impasses necessitam ser esclarecidos para que o tratamento seja recomendado com mais segurança na prática clínica. Conclui-se que o uso de infiltrantes resinosos tem sido relatado como promissor para o tratamento de lesões cariosas incipientes, contudo há necessidade de novas pesquisas e estudos a longo prazo para confirmar sua eficácia em todos aspectos desejáveis para seu uso clínico. Palavras-chave: Cárie Dentária. Infiltração Dentária. Remineralização Dentária.
Response of osteoarthritis biomarkers after a rehabilitation program: study protocol
Authors: Antonioli Eliane , Oliveira Felipe B. D. , Campedelli Rosana R. , Zorzi Alessandro R. , Specialli Danielli , Agarwal Sudha , Ferretti Mario 
Published: January 2020

<p class="abstract"><strong>Background:</strong> Knee osteoarthritis is a progressive degenerative joint disease and remains a leading cause of pain, physical impairment and decline in health-related quality of life in adults. Despite its incidence being amongst the highest in chronic diseases, effective biomarkers are not available to assist in its management. The main goal of this study is to identify mediators that serve as biomarkers and investigate if the levels of these biomarkers will be correlated to the efficacy of a rehabilitation program.</p><p class="abstract"><strong>Methods:</strong> This is a prospective cohort study with 65 participants. Patients with mild-to-moderate symptomatic knee osteoarthritis will be recruited. The Rehabilitation Program will consist of three session/week during eight weeks. Assessment about functional evaluation will be performed before and after treatment, using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and EuroQOL-5D (Euro quality of life - five dimension) scales, Visual Analog Scale (VAS), and physical function tests (time up and go, isometric strength testing and kinematic gait analysis). Serum levels of classical pro-inflammatory cytokines, hyaluronan and high mobility group box 1 protein (HMGB-1) will be evaluated. The primary outcome is the change in WOMAC scale from baseline to end. Statistical analyses will be used to determine correlation of physical improvement and serum biomarkers. Adverse events will be monitored throughout the study.</p><p class="abstract"><strong>Conclusions: </strong>This trial expect to study the correlation between the anti-inflammatory effects of rehabilitation program derived factors that may be involved in suppressing cytokine induction via suppressing HMGB-1.</p><p class="abstract"><strong>Trial registration:</strong> Clinicaltrials.gov - NCT02964624.</p>
Need of the hour? does breast milk bank reduces perinatal morbidity and mortality: a retrospective observational study
Authors: E. Narayanan , Sajjid Mohd , Kumar Arun 
Published: January 2020

Background: Human milk bank plays an essential role by providing human milk to infants who would otherwise not be able to receive human milk. The aims and Objectives is to study the morbidity and mortality outcome profile of babies fed with PDHM (pasteurized donor human milk) comparing data between Pre Human Milk Breast bank (2015) and Post Human Milk Breast bank (2016, 2017 and 2018).Methods: Milk bank collect, screen, store, process, and distribute human milk. Retrospective observational study was done in Department of Neonatology, Institute of Obstetrics and Gynaecology and Women and Children Hospital, Chennai. Data obtained retrospectively comparing data Pre HMB (2015) and Post HMB (2016, 2017 and 2018).Results: In this study authors collected the data comparing Pre human milk bank (Pre HMB) and Post human milk bank (Post HMB). After starting human milk bank, around 1799 babies were benefitted and 14.45 lakh ml milk was collected from 16000 donor mothers in last 3 years. Bacterial contamination rate of PDHM has reduced to 4.39% (2018) compared to 7.73% (2016) with P Value 0.0042 (statistically significant). CONS and Staphylococcus aureus were the most common Organisms isolated. There was reduction in morbidity profile like sepsis rate, NEC/ Feed intolerance and ROP profile. Mortality profile also reduced to (7.73-9.31%). Duration of hospital and Duration to attain full feeds were improved all GA group babies.Conclusions: In this study, after starting human milk bank there was reduction in mortality, morbidity outcome, sepsis. Duration to attain full feeds and duration of hospital stay reduced. We concluded that establishment of breast milk bank will be more useful and beneficial for all GA group babies for better outcome.
A prospective observational study to describe magnetic resonance imaging findings in perinatal asphyxia in terms of severity, outcome and neurological sequel in term and preterm babies
Authors: Mondal Tanushree , Gayen Gargi , Bhowmik Arijit 
Published: January 2020

Background: Perinatal asphyxia is a significant cause of neonatal mortality and morbidity. MRI is useful for assessing the severity and pattern of brain injuries. There is less data of MRI findings of perinatal asphyxia from India and the subcontinents. This prospective observational study was done to describe MRI brain findings in neonates with perinatal asphyxia with respect to various determinants.Methods: Initial MRI brain was done when babies were stable after fulfilling inclusion criteria. Immediate outcome was assessed at the end of hospital stay. They were followed up for presence of any sequel up to 1 year. Repeat MRI brain was done in few selected babies. Data was collected and statistically analyzed.Results: Total 55 babies were included in the study (term 27, preterm 28). There were 9 babies in stage 1, 17 babies in stage II and 22 babies in stage III. MRI brain findings were normal in 8 and abnormal in 47 patients. There were Deep gray matter injury (DG) in 22, Para Sagittal subcortical white matter injury (PS) in 6, Germinal matrix haemorrage (GMH), intraventricular haemorrage (IVH) and Periventricular leucomalacia (PVL) in 12 and Mixed pattern of injury in 7 babies. Findings among 9 expired babies were: 4 (44.4%) DG, 2 (22.2%) GMH+IVH and 3 (33.3%) mixed. There was neurological sequel in 13 babies (48.1%). Babies with normal MRI initially had no sequel.Conclusion: Brain injury due to perinatal asphyxia follows several patterns according to gestational age and severity. Early and accurate recognition of these patterns with the help of MRI brain helps in managing the baby and predicting the prognosis.
Yale observation scale for bacterial infection in febrile children
Authors: Mangla Shiwani , Jain Hemant 
Published: January 2020

Background: Sepsis is one of the leading causes of mortality in children under 5 years by UNICEF statistics which is difficult to diagnose because of nonspecific initial clinical presentation and potential for rapid deterioration. In this regard use of Yale Observation Scale assists in early recognition of serious bacterial infection than other laboratory investigation as it is simple, quick, easy to apply and cost-effective bed side scale.Methods: All eligible young febrile infants and children were consecutively enrolled in the study. Axillary temperatures of the cases were documented. Yale observation scoring was done. Blood sample were sent for culture and sensitivity. Colonies were identified morphologically by Gram stain and biochemically. The collected data was analyzed using ROC curve for finding cut off scores of Yale Observation Scale for prediction of severe bacterial illness and final outcome. Statistical analysis was performed using the Statistical Packages for Social Sciences (SPSS) version 14 for MS Window.Results: Bacteremia was found in 23(15.3%) out of total 150 young febrile children enrolled in the present study. It shows that in lower YOS score blood culture was sterile and in higher YOS score blood culture was positive for bacteremia, which is statistically significant with p value (<0.05). As per ROC curve analyses the best cut off value of YOS for prediction of bacteremia was 17.5 with sensitivity 91.3%, specificity 81.9%, PPV 47.7% and NPV of 98.1%.Conclusions: YOS of >17.5 has a good predictive ability for prediction of bacteraemia in young febrile children.