bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Feasibility Pilot Study on the Use of Telemedicine for
the Examination of the Knee Joint
Authors: Scheidt Sebastian , Kehrer Michael , Welle Kristian , Wimmer Matthias D. , Jaenisch Max , Goost Hans , Wirtz Dieter Christian , Burger Christof , Kabir Koroush 
Published: November 2020

Abstract
Background In times of a pandemic threat, such as COVID-19, and the need
for reduced direct doctor-patient contact, internet-based telemedicine has
attracted more and more attention as a surrogate service. Suspending the
diagnosis and treatment of non-virus related diseases for longer periods of time
is not a viable option since this would only exacerbate problems on the patient
and national level. The need for alternative treatment modalities increased
rather quickly. So far, telemedical applications have mainly focused on
teleradiological diagnosis, follow-up and monitoring of psychiatric and internal
diseases, as well as geriatric patient care. As far as these authors are aware,
orthopaedic physical examination of the knee joint, including trauma work-up,
has not been the subject of any studies to date. This feasibility study explores
how video consultation can be designed and implemented in the context of history
taking and physical examination in knee joint complaints.
Material and Method 21 patient actors (PA) with simulated complaints of
the knee joint were examined individually for each diagnosis, first via video
consultation and then directly by a specialist (SP). One PA group has a medical
background, the other was made up of laypersons. The time was measured for both
types of consultation. The physician documented the detected symptoms, the
quality of implementation of the self-examination steps, and the derived
diagnosis on an assessment form. After completion of both consultation sessions,
the PAs were handed a questionnaire on the respective examination modality.
Results With the video consultation the examination lasted 8.63 (± 2.5)
minutes on average and with the regular consultation in person 5.63 (± 1.7)
minutes (p < 0.001). For the group with medical background the examination
lasted 7.67 (± 1.4) minutes on average, while for the lay group the video
consultation took 9.7 (± 3.1) minutes (p = 0.049). With increased age, the video
consultation was prolonged (p = 0.032; r = 0.47). The mean value for
self-examination of leg axis, gait pattern and degrees of freedom was 9.32
(± 0.4) of 10 points. The following functional tests resulted in lower mean
values (points): Payr 7.2 (± 2.3), Merke 5.9 (± 2.8), no-touch Lachmann 6.4
(± 2.7), gravity sign-recurvatum 6.7 (± 2.4). The mean grade by the PAs for the
feasibility of self-examination was 2.43 (± 0.98) out of 5 points.
Conclusion The video consultation for musculoskeletal complaints of the
knee joint allows exploratory remote examination and helps to minimise the
number of patients in hospitals and practices. It takes longer for the physician
to perform and does not permit functional testing for ligament injuries of the
knee joint. In its present form, telemedical examination is not able to fully
replace personal consultation.
Umsetzung von Behandlungskontinuität im Versorgungsalltag – ein Vergleich zwischen zwei psychiatrischen Kliniken
1
Authors: Assheuer Michaela , Beine Karl , Mehl Claudia , Kellner Michael , Agelink Marcus , Sieberer Marcel , de Cruppé Werner , Geraedts Max 
Published: November 2020

Zusammenfassung
Ziel der Studie Die starre Trennung von ambulanter und stationärer Versorgung im deutschen Gesundheitssystem verhindert eine Behandlungskontinuität, obwohl sie sich für psychiatrische Patienten als sehr wichtig erwiesen hat. Die vorliegende Studie analysiert die Behandlungskontinuität einer Modellklinik mit einem Gesamtbudget nach § 64b SGB V und konstantem Behandlungspersonal über alle Settings hinweg im Vergleich zu einer Kontrollklinik mit Regelfinanzierung ohne ein solches Team.
Methodik In einer prospektiven Kohortenstudie mit einem Beobachtungszeitraum von 20 Monaten wurden Daten zur Behandlungskontinuität von 220 Patienten der Modellklinik und 215 Patienten der Kontrollklinik erhoben.
Ergebnisse Die Modellklinik erreichte eine signifikant höhere Behandlungskontinuität als die Kontrollklinik, sowohl während der stationären Behandlung zum Zeitpunkt der Rekrutierung als auch in allen Settings während des Beobachtungszeitraums.
Schlussfolgerung Ein Gesamtbudget kann die notwendigen Voraussetzungen für eine flexiblere psychiatrische Versorgung und eine bessere Umsetzung der Behandlungskontinuität schaffen.
Das Virus und die Digitalisierung: Treibt Corona die digitale Evolution des deutschen Gesundheitswesens voran?
Authors: Straub Christoph 
Published: November 2020

ZusammenfassungMit dem Digitale-Versorgung-Gesetz öffnete die Bundesregierung den Weg für einen deutlichen Schub bei der Digitalisierung des Gesundheitswesens. Durch die Corona-Krise hatte es einen weiteren starken Impuls in diese Richtung gegeben. Dennoch sorgt der sprunghafte Anstieg der digitalen Möglichkeiten mitunter auch für Unsicherheit unter Patientinnen und Patienten wie Ärztinnen und Ärzten. Besonders die Mediziner artikulieren einen großen Informationsbedarf. Diesen zu decken, ist auch im Sinne der Krankenkassen. Denn es kommt nicht nur auf den Nutzen digitaler Gesundheitsanwendungen an, sie müssen auch tatsächlich implementiert werden, damit alle Beteiligten, nicht zuletzt die Patienten, davon profitieren.
Risikoanalyse im Krankenhaus – Die Pandemie als unterschätztes Risiko?!
Authors: Müller Anna 
Published: November 2020

ZusammenfassungEine Pandemie, wie die durch das Coronavirus, kann in Deutschland nicht als unterschätztes Risiko bewertet werden, da mit dem nationalen Pandemieplan bereits Maßnahmen zur Vorsorge definiert werden. Jedoch zeigt die Risikoanalyse, dass weitaus mehr Risiken und Auswirkungen infolge des Virus auftreten können, welche teilweise bisher nicht berücksichtigt wurden. Anhand von erkennbaren Auswirkungen und dem Ansatz der Business Impact Analyse nach der DIN EN ISO 22301 werden einzelne Risiken aufgeführt. Schlussfolgernd ist festzuhalten, dass die Risiken einer Pandemie vielfältig sind, die Vorsorge bisher nur grundlegende Maßnahmen umfasst und eine verbesserte Vorsorge den Schaden und damit die Kosten reduzieren kann.
Führung: eminenz- oder evidenzbasiert?
Authors: Ebner Markus 
Published: November 2020

ZusammenfassungDas PERMA-Modell gilt als Standard für Potenzialentfaltung. Jeder Buchstabe von PERMA steht für eine Voraussetzung, die Menschen brauchen, um ihr volles Potenzial auszuschöpfen. Dabei ist jeder einzelne Aspekt messbar und beeinflussbar – mit großem Nutzen für die Praxis.
Der „Hilfsverein für Nerven- und Gemütskranke in Württemberg“ – Zur Geschichte poststationärer Begleitung psychisch Kranker, 1895–1975
Authors: Luigart Sylvia , Kanis-Seyfried Uta , Reichelt Bernd , Müller Thomas 
Published: November 2020

ZusammenfassungDieser psychiatriehistorische Beitrag gibt einleitend einen Überblick über die Entwicklung der psychiatrischen Hilfsvereine in Deutschland und beschreibt in der Folge Geschichte und Tätigkeitsprofil des genannten Hilfsvereins in Württemberg von dessen Gründung bis ca. 1975. Hierfür wurde das Archiv des bis heute existierenden, inzwischen für ganz Baden-Württemberg zuständigen, Vereins ausgewertet. Der Hilfsverein nahm seit seiner Gründung eine zentrale Position in der poststationären Begleitung und Unterstützung von psychisch kranken Menschen ein. Bis 1945 stand die Einzelfall- und Angehörigen-Unterstützung im Vordergrund. Mit dem Ausbau der sozialpsychiatrischen Versorgungsstrukturen, beginnend Ende der 1960er-Jahre, verlagerte sich der Fokus der Arbeit auf die Unterstützung von Projektarbeit. Die Geschichte des Hilfsvereins weist hierbei deutliche Zäsuren auf, wie auch Anpassungen an politischen Wandel sowie Veränderungen durch die Entwicklung des psychiatrischen Versorgungssystems.
An Unusual Case of Iron-Deficiency Anemia: The Culprit Hides in the Aorta
Authors: Lock Guntram , Bertram Mathias , Oelckers Michael , Bitz Ulrich , Zipfel Burkhart , Jacobsen Frank 
Published: November 2020

AbstractIn a 72-year-old patient with anemia (Hb 7 g/dl), duodenoscopy exhibited an area of polypous irregular-looking mucosa. Histology revealed duodenal infiltration by epithelioid tumor cells, immunhistochemically positive for endothelial cell markers (CD34, CD31, ERG). Ultrasonography showed thrombotic material in the otherwise unremarkable abdominal aorta with some uptake of contrast bubbles on CEUS. Histological and clinical diagnosis assumed an epithelioid angiosarcoma of the thoraco-abdominal aorta at the level of the visceral and renal arteries with duodenal metastases.To prevent further shedding of tumor cells and aortic rupture, a branched stent-graft was placed into the thoraco-abdominal aorta. Palliative chemotherapy with gemcitabine and docetaxel was started, leading to a partial remission after 6 cycles. Three months later, however, there was a progress of the duodenal masses with new pulmonal and osseous metastases. Thirteen months after the initial diagnosis, death occured due to a hemorrhagic shock caused by a hematothorax.Aortic tumors are exceedingly rare, with only slightly more than 220 cases reported so far. In most cases, diagnosis is made either at autopsy or after an emergency operation for embolic complications like embolic intestinal ischemia. With an overall median survival of 8 months, prognosis is very poor.This case sensitizes for the correct sonographic interpretation of aortic “thrombi” in an otherwise normally appearing aorta, possibly with the aid of CEUS. Besides, it demonstrates the relatively early and uncommon diagnosis of an aortic angiosarcoma by the combination of endoscopy, immunohistochemistry, and ultrasonography.
Shining Light on the Light-Bearing Element: A Brief Review of Photomediated C–H Phosphorylation Reactions
Authors: Li Chao-Jun , Ung Sosthène P.-M. , Mechrouk Victoria Atica 
Published: November 2020

AbstractOrganophosphorus compounds have numerous useful applications, from versatile ligands and nucleophiles in the case of trivalent organophosphorus species to therapeutics, agrochemicals and material additives for pentavalent species. Although phosphorus chemistry is a fairly mature field, the construction of C–P(V) bonds relies heavily on either prefunctionalized substrates such as alkyl or aryl halides, or requires previously oxidized bonds such as C=N or C=O, leading to potential sustainability issues when looking at the overall synthetic route. In light of the recent advances in photochemistry, using photons as a reagent can provide better alternatives for phosphorylations by unlocking radical mechanisms and providing interesting redox pathways. This review will showcase the different photomediated phosphorylation procedures available for converting C–H bonds into C–P(V) bonds.1	Introduction1.1	Organophosphorus Compounds1.2	Phosphorylation: Construction of C–P(V) Bonds1.3	Photochemistry as an Alternative to Classical Phosphorylations2	Ionic Mechanisms Involving Nucleophilic Additions3	Mechanisms Involving Radical Intermediates3.1	Mechanisms Involving Reactive Carbon Radicals3.2	Mechanisms Involving Phosphorus Radicals3.2.1	Photoredox: Direct Creation of Phosphorus Radicals3.2.2	Photoredox: Indirect Creation of Phosphorus Radicals3.2.3	Dual Catalysis3.3	Photolytic Cleavage4	Conclusion and Outlook
Recent Advances in Metal-Catalyzed, Electrochemical Coupling Reactions of sp2 Halides/Boronic Acids and sp3 Centers
Authors: Gale-Day Zachary J. 
Published: November 2020

AbstractTraditionally, metal-catalyzed cross-coupling reactions rely on stable but expensive metals, such as palladium. However, the recent development of synthetic organic electrochemistry allows for in situ redox manipulations, expanding the use of cheaper, abundant and sustainable metals, such as nickel and copper as efficient cross-coupling catalysts. This short review covers the recent advances in metal-catalyzed electrochemical coupling reactions, with a focus on reactions of sp2 electrophiles and nucleophiles with sp3 coupling partners to form both C–C and C–heteroatom bonds.1	Introduction2	Nickel-Catalyzed C–C sp2–sp3 Coupling Reactions3	Coupling of Aryl Groups with Heteroatomic Nuclei4	Conclusion
Vitamin B12-Catalyzed Dicarbofunctionalization of Bromoalkenes Under Visible Light Irradiation
Authors: Smoleń Sabina , Wincenciuk Aleksandra , Gryko Dorota , Drapała Olga 
Published: November 2020

AbstractVitamin B12 plays a crucial role in enzymatic transformations. This natural compound proved also useful as a catalyst in numerous organic reactions. Commercial availability and lower cost than precious metal complexes, make cobalamin an attractive candidate for a broader use as a benign Co-catalyst. Herein, the vitamin B12-catalyzed dicarbofuntionalization of bromoalkenes with electrophilic olefins is reported leading to substituted pyrrolidines and piperidines in decent yields after only 15 minutes under light irradiation.
Endoscopic Endonasal Odontoidectomy with Nasopharyngeal Flap Reconstruction
Authors: London Nyall R. , Mohyeldin Ahmed , Carrau Ricardo L. , Prevedello Daniel M. 
Published: November 2020

Abstract
Objective This study aimed to demonstrate the nuances in preoperative management, surgical technique, and reconstruction for an endoscopic endonasal odontoidectomy.
Design Assembly of an operative video demonstrating technique for endoscopic endonasal odontoidectomy.
Setting this study is a comprehensive skull base team at a tertiary care center.
Participant The patient is a 53-year-old male, with basilar invagination and myelopathy, who underwent cervical fusion, 6 years back, without ventral decompression at an outside hospital. He presented to our clinic with persistent myelopathy and generalized weakness, thus an endoscopic endonasal odontoidectomy for brainstem decompression was recommended.
Main Outcome Measures Preoperative computed tomography (CT) angiography and intraoperative CT navigation demonstrated normal carotid artery anatomic localization. An inverted U-shaped mucosal flap was reflected inferiorly and preserved. The C1 arch was identified and resected with a high speed drill. The resultant diseased soft tissue arising from retropulsion of the odontoid process was then removed and the odontoid process identified. This bone was removed centrally until a thin cap remained. After removal of the cap, the underlying ligamentous tissue was removed until dural pulsations were appreciated and brainstem decompression achieved. Hemostasis was attained and the mucosal flap mobilized into position.
Results Postoperative CT imaging demonstrated resolution of basilar invagination and brainstem decompression (Fig. 1). The patient improved both in arm dexterity and ambulation after surgery and the reconstruction demonstrated appropriate healing on nasal endoscopy 2 months postoperatively.
Conclusions This operative video demonstrates nuances in endoscopic endonasal odontoidectomy. This case also demonstrates that ventral decompression after long-term cervical fusion can improve myelopathy and that fusion in the setting of bony ventral compression, rather than rheumatoid panus, may not reduce over time with fusion only.The link to the video can be found at: https://youtu.be/370FFuBA89Y.
Percutaneous Reconstruction of the Ulnar Collateral Ligament of the Metacarpophalangeal Joint of the Thumb: Technique and Results
Authors: Herrera Juan Manuel , Herrera Lucas , Rotella Pablo , Cantero Téllez Raquel , Castellanos Jimena , Vázquez Fernando 
Published: November 2020

Abstract
Objectives The present study aims to describe a new percutaneous technique for the reconstruction of the ulnar collateral ligament of the metacarpophalangeal joint of the thumb with a tendon graft, and to evaluate the functional outcomes and stability six months postoperatively.
Material and methods The percutaneous ligamentoplasty technique was performed with a palmaris longus tendon graft and tenodesis screws in 6 patients with ulnar instability of the thumb (> 30° degrees of radial deviation) for more than 6 weeks. Range of motion, grip strength, and pinch strength (lateral/key pinch, tip pinch, and palmar pinch) were assessed in comparison to the contralateral limb, as well as the Quick Disabilities of the Arm, Shoulder and Hand (DASH) score.
Results At 6 months, the joint movement was of 100%, the grip strength was of 94.8%, the key pinch was of 95%, the palmar pinch was of 85.7%, and the tip pinch was of 93.5% compared to the contralateral limb. The internal tilt was of 14° compared to 9° at the contralateral limb. The Quick DASH score decreased from 24.2 to 2.6 points.
Conclusion We devised this versatile surgical procedure to obtain early mobility with the advantages related to the percutaneous techniques.
Xantoma del tendón de aquiles bilateral: Debut de xantomatosis cerebrotendinosa
Authors: Fernández-Ruiz María Dolores , Moril-Peñalver Lorena , Sevilla-Monllor Alexandra , García-Ortiz María Tíscar , Lizaur-Utrilla Alejandro , López-Prats Fernando 
Published: November 2020

Resumen
Objetivo Presentación de un inusual caso de xantomatosis cerebrotendinosa en un paciente de edad cuya primera manifestación fueron xantomas bilaterales del tendón de Aquiles.
Material y métodos Mujer de 62 años, que presenta tumoraciones, que presenta tumoraciones sólidas y polilobuladas, en la cara posterior de ambos tendones de Aquiles de 8 años de evolución. El diagnóstico se realizó mediante el hallazgo de hiperlipidemia y estudio genético. Se realió la exóresis quirúrgica parcial de las tumoraciones.
Resultados A los 5 años de la cirugía del pie izquierdo y 4 años del pie derecho la paciente estaba asintomática. Presentaba una fuerza para la flexión plantar bilateral de 5/5, pudiendo caminar y subir escaleras sin molestias. Presentaba una escala AOFAS de 85 y 90 puntos en el pie izquierdo y derecho, respectivamente. No hubo recidivas.
Discusión Los xantomas son depósitos de colesterol en el tejido conectivo de la piel, tendones o fascia, como resultado de una hiperlipoproteinemia. La importancia del caso radica en su sospecha diagnóstica, ya que la xantomatosis cerebrotendinosa suele manifestarse en pacientes de menos de 30 años de edad y en los que se ha recomendado la resección radical de las tumoraciones, e incluso del tendón, debido a las frecuentes recidivas.
Conclusión En pacientes de mayor edad con lesiones que infiltran el tendón, se puede optar por un tratamiento menos agresivo con un buen resultado clínico.
Nivel de evidencia IV
Artroplastia de resección de hombro como salvamento para infecciones recalcitrantes. Estado actual de la técnica a propósito de dos casos
Authors: Arbeloa-Gutierrez Lucas , Arenas-Miquelez Antonio 
Published: November 2020

Resumen
Introducción y Objetivos La artroplastia de resección de hombro (ARH) se presenta como una técnica obsoleta y una opción no válida en la actualidad, debido a la evolución de las técnicas quirúrgicas y de los implantes. Pero, como consecuencia del aumento exponencial del uso de artroplastias de hombro, están aumentando en paralelo el número de fracasos e infecciones, con necesidad de revisión y rescate. Es por ello que, en determinadas situaciones y pacientes, esa técnica vuelve a ser una opción necesaria como salvataje, aunque tiene un alto coste funcional. El objetivo de nuestro trabajo, es presentar dos casos de artroplastia de resección de hombro como una opción válida de tratamiento en la actualidad y la revisión de la literatura.
Casos Se presentan dos casos de ARH como tratamiento de rescate, en un caso de osteomielitis crónica de cabeza humeral y un caso de infección de hemiartroplastia de hombro. Ambos pacientes se encontraban sin dolor y libres de infección con un seguimiento de más de 30 meses. En un caso la funcionalidad fue limitada con un Constant de 45 pero el otro caso la funcionalidad fue aceptable con un Constant de 67.
Conclusiones La ARH sigue siendo una técnica útil tras el fracaso de procedimientos de revisión, para resolver infecciones protésicas recalcitrantes u osteomielitis. Los resultados funcionales son pobres, por lo que debe reservarse para pacientes con baja demanda funcional y como salvataje, tras agotar otras opciones.
A Rare Cause of Facial Paralysis in Children: A Case of Ramsay Hunt Syndrome
Authors: Çiçek Muharrem , Kılıç Zeynep , Mercen Yezdanşer , Karaoğlan Emel , Öztarhan Kazım 
Published: November 2020

AbstractPeripheral facial paralysis in children can have many causes including trauma, otitis media, head and neck tumors, congenital anomalies, viral infections, as well as metabolic and genetic factors. One cause of peripheral facial paralysis is Ramsay Hunt syndrome (RHS), which is also known as herpes zoster oticus, affecting the seventh and eighth cranial nerves. It is characterized by inner ear dysfunction, periauricular pain, and peripheral facial paralysis accompanied by the presence of an erythematous vesicular rash around the ear pinna and outer ear canal or in the oral mucosa. RHS is very rare in children when compared with its prevalence in adults. A 13-year-old male with no prior medical history applied to the pediatric emergency department after having first developed a vesicular rash on the left ear pinna and pain around the left ear, which was followed 1 day later by the development of ipsilateral facial asymmetry. The patient was hospitalized and simultaneously started on 2 mg/kg/d methylprednisolone for 10 days (followed by a 15-day taper), 100 mg/kg/d intravenous ceftriaxone twice per day (stopped on day 10), 30 mg/kg/d intravenous acyclovir three times per day (stopped on day 21), ciprofloxacin ear drops, tobramycin eye drops, ointment, and artificial tear drops with eye patching. However, only a minimal improvement was observed in the patient's peripheral facial paralysis by day 21. When compared with the prevalence in adults, RHS is very rare in children, which is why reports of pediatric RHS are limited in the literature. Therefore, additional studies are needed to provide information about the pathophysiology, diagnosis, and treatment of pediatric RHS.
Detection of Streptococcus pneumoniae in Urine by Loop-Mediated Isothermal Amplification
Authors: Cima-Cabal María Dolores , Vázquez-Espinosa Emma , Vazquez Fernando , García-Suárez María del Mar 
Published: November 2020

Abstract
Objective To assess the loop-mediated isothermal amplification (LAMP) to detect cell-free DNA from Streptococcus pneumoniae in urine samples from children with pneumococcal pneumonia.
Methods LAMP reactions using four primers (backward inner primer, forward inner primer, B3, and F3) targeting conserved regions of the S. pneumoniae ply gene and DNA from the recombinant plasmid pTrc99A-ply were optimized for temperature (65°C) and MgSO4 concentration (8 mM) conditions. Urine samples from 71 patients with symptoms of pneumonia and from 17 healthy children were tested side by side using the isothermal methodology LAMP and the commercial urinary antigen test, BinaxNOW S. pneumoniae assay. Percentages of sensitivity, specificity, positive predictive value (PPV), negative predictive value, and positive (LR) were calculated to compare both tests.
Results The specificity of the LAMP reaction was confirmed against several species of bacteria and yeast that can cause pneumonia or urine infections. The suitability of the LAMP assay was evaluated in urine samples from 71 patients and 17 healthy children. All patients (100%) with confirmed pneumococcal pneumonia were positive for the LAMP assay. Among patients with possible/probable pneumonia, 74.1% were identified as positive using the LAMP test. Notably, a higher specificity (95.4%), PPV (94.1%) and positive LR (21.7) were found compared with the urinary antigen test.
Conclusion The presence of S. pneumoniae cell-free DNA in urine samples of pediatric patients can be used as a specific diagnostic biomarker for community-acquired pneumonia by using the LAMP methodology.