bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomized controlled trial of a peer-led pain management program for older adults: Baseline characteristics and preliminary results
Authors: Tse Mimi Mun Yee , LI Yajie , Tang Shuk Kwan , Ng Shamay Sheung Mei , Bai Xue , Lee Paul H. , LO Raymond 
Published: June 2020

Abstract
Background

Chronic pain is common among nursing home residents and they may have difficulty seeking out pain management strategies. Due to the limitation of healthcare resources, peer support model was proved with promising effect in managing chronic conditions.

Methods

It is a clustered randomized controlled trial. Peer-led pain management program was provided for the experimental group. Pain situation, depression, quality of life, non-drug strategies used and pain knowledge were measured.

Results

Totally 262 participants joined the study. Their overall pain score was 6.36. Leg was the most frequently reported site of pain and walking ability was interfered. Depression was also reported by the participants. The score for quality of life was 32.65 for physical component and 51.58 for mental component. The mean score for pain knowledge was 46.81 out of 100. No significant difference was shown between two groups at baseline.

Discussion

Severe pain intensity and low self-efficacy among the participants indicated it is necessary to provide pain management programs especially for this population. The frequency with strategies applied were significantly correlated with pain intensity, pain interference, depression, and quality of life. Pain knowledge also correlated significantly with some strategies.
Monetary and Fiscal Policy Coordination During the Fiscal Dominance Regimes
Authors: Swamy Vighneswara 
Published: June 2020

Abstract
This study evaluates the conduct of monetary and fiscal policies for the post-liberalization period 2005: Q1–2017: Q1 in India and explores the need for coordination. As quantifying the extent of coordination, mostly depends on the appropriate policy mix that responds effectively to different shocks, this study empirically examines the interaction between monetary and fiscal policy by using Vector Auto Regressions (VAR) and a Vector Error Correction Model (VECM). Further, this study discusses the Stackelberg interaction model with government leadership to know the strategic interaction between monetary and fiscal policy. The estimates show that an unexpected increase in the monetary policy effect: (i) has a contractionary impact on the economic growth; (ii) leads to a gradual decline in the inflation; (iii) tightens the liquidity conditions; and (iv) rise in the bond yields. On the other hand, an unexpected increase in the fiscal policy effect: (i) has a positive effect on GDP growth; (ii) has an initial decline, but a gradual rise in the inflation levels; and (iii) leads to falling bond yields. Monetary policy is found to be more responsive to fiscal policy effects. The results imply that there is a greater need for effective coordination between monetary and fiscal policy as a sufficient condition to achieve economic stability.JEL Classification: C32; E31; E52; E62; E63
The clinical effects and biomechanical mechanisms of Peony and licorice decoction fumigation in the treatment of poststroke cavovarus foot: study protocol for a randomized controlled pilot trial
Authors: Jing Chengyang , Zhou Li , Ai Juanjuan , Li Zongheng , Wu Jiabao , Sun Yiting , Zhao Shuang 
Published: June 2020

Abstract
Background: As the most common functional disability in stroke patients with hemiplegia, poststroke cavovarus foot (PCF) seriously affects the life quality of patients and causes mental and emotional disorders. Some studies have suggested that the traditional Chinese medicine fumigation therapy could be an effective intervention method for PCF patients. This study aims to investigate the biomechanical effect of the classic prescription Peony and licorice decoction (PLD) fumigation in the treatment of PCF. Methods/Design: This study is a multi-center, randomized, placebo-controlled, double blind trial. A total of 190 patients with PCF according to the inclusion criteria will be recruited in three centers and randomized and distributed to either the intervention group or the control group at a 1:1 ratio. All patients will receive standardized modern rehabilitation treatment according to the “Chinese Guidelines for Stroke Rehabilitation” (2011 version). Patients will stick to the treatments they used to take, and will be given present general treatment when acute exacerbation of stroke occurs during the trial. The intervention group will receive PLD fumigation treatment, while the control group will receive placebo fumigation treatment. The primary outcome measure is medial plantar area (M1＋M2＋HM) generating from the RSSCAN gait system. The secondary outcome measures contain the scores of clinical scales including Berg Balance Scale, Fugl-Meyer Assessment, Modified Ashworth Scale, Barthel Index, and Stroke-Specific Quality of Life Scale. All assessments will be implemented at baseline, 4 weeks after intervention and at the end of 3 month’ follow-up. Intention-to-treat analysis and per-protocol analysis will be applied in this trial. Discussion: The results of this study are expected to provide detailed interpretations of clinical effects and biomechanical mechanisms of PLD fumigation in the treatment of PCF. If PLD fumigation treatment is confirmed as an effective option, this study may additionally set up the new treatment method for patients with PCF and provide foundations for further clinical studies on a larger scale. Trial registration: Chinese Clinical Trial Registry, ChiCTR2000032433. Registered on 28 April 2020.
Long-term Results of Additional Pulmonary Blood Flow With Bidirectional Cavopulmonary Shunt
Authors: Kowatari Ryosuke , Suzuki Yasuyuki , Daitoku Kazuyuki , Fukuda Ikuo 
Published: June 2020

Abstract
Objective: We evaluatedadditional pulmonary blood flowat the time of bidirectional cavopulmonary shunt andits effectson the Fontan procedure andlong-term outcome of Fontan circulation and liver function.Methods: We included 22patients (16 boys, 6 girls) having undergonebidirectional cavopulmonary shunt with additional pulmonary blood flow between April 2002 and January 2016. Mean ageand body weight were 20 ±13 monthsand 7.5 ± 6.5 kg, respectively.We retrospectively evaluated the patients'clinical data,including cardiac catheterization data, liver function, and liver fibrosis markers.Results: All patients werealive with a New York Heart Association status of I at the long-term follow-up. Changes between pre-bidirectional cavopulmonary shunt and 101 months after the Fontan procedure included the following:the cardiothoracic ratio of chest X-ray decreased from 52.2 ± 3.9% to 41.8 ± 5.9% (p<0.001);systemic ventricle end-diastolic pressure decreased from 11.4±3.2 mmHg to 6.9±3.6mmHg(p<0.001);and the pulmonary artery index decreased from 485.1±272.3 to 269.5 ± 100.5(p=0.02). Type IV collagen, hyaluronic acid, and procollagen levels increased over the normal range 116 months after the Fontan procedure.Conclusions:The additional pulmonary blood flowat the time of bidirectional cavopulmonary shuntmaycontributeto pulmonary arterial growth at the Fontan procedure with low pulmonary arterial resistanceand without ventricle volumeoverload. The Fontan circulation was well-maintained at thelong-term follow-up, while liver fibrosis markerswere above their normal values.
Network Pharmacology Study of Curcuma Longa: Potential Target Proteins and their Functional Enrichment Analysis.
Authors: KUMARI SANGEETA 
Published: June 2020

Abstract
Objective: This study’s primary goal is unraveling the mechanism of action of bioactives of Curcuma longa L. at the molecular level using protein-protein interaction network.Results: We used target proteins to create protein-protein interaction network (PPI) and identified significant node and edge attributes of PPI. To find the function module, we identified the cluster of proteins which were further queried to GO enrichment analysis. Closeness centrality and jaccard score identified as most important node and edge attribute of the protein-protein interaction network respectively. The mapped pathways of various function module of the network were overlapped and showed synergistic mechanism of action. Three most important identified pathways were Gonadotropin-releasing hormone receptor pathway, Endothelin signaling pathway, and Inflammation mediated by chemokine and cytokine signaling pathway.
Epidemiology of Diabetes in adults in GanSu province of northwest China
Authors: Zhang Qi , Liu Jing , Guo Tiankang 
Published: June 2020

Abstract
Objective:The purpose of this study was to study the characteristics and distribution of adult diabetes and prediabetes in Gansu province, northwest China.Methods : Using a stratified, cluster and random sampling design, we conducted a population-based, cross-sectional survey in GanSu province of northwest China. A representative sample of 31417 adults, aged 20-74 years, from 14 regions participated in the study. After an overnight fast, a 2-hour oral glucose tolerance test (OGTT) 75 g glucose load was conducted among participants without a self-reported history of diagnosed diabetes. Questionnaire survey, physical examination and serum lipid level were also conducted in the study. The Epidata version 3.1 and SPSS version 21.0 were used for data inputting and statistics analyzing. Results: The rough prevalence of diabetes in adults in Gansu province of northwest China was 10.6% (12.3% among men and 9.2% among women) and the age-standardized prevalence of diabetes is 9.0%. The prevalence of diagnosed and emerging diabetes was 5.2% and 5.4%, respectively. The prevalence of diabetes among Han, Hui, Tibetan, Yugur, Dongxiang nationality and the Baoan nationality were 10.7%, 11.3%, 5.5%, 7.7%, 8.9% and 7.9% respectively. In addition, the prevalence of prediabetes was estimated to be 15.2% (15.7% among men and 14.7% among women). The prevalence of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) were 3.5% and 11.6% respectively. The prevalence of diabetes and prediabetes increased with increasing age and body mass index (BMI). The prevalence of diabetes among urban residents was higher than that among rural residents (11.5% vs. 9.5%) which is different from prediabetes (14.2% vs. 16.3%). Binary logistic regression analysis showed that age, male sex, urban residents, smoking, family history of diabetes, abdominal obesity, overweight, generalized obesity, hypertension, dyslipidemia, low levels of education, and high level of economic development were significantly associated with diabetes. Simultaneously, age, male sex, rural residents, drinking, abdominal obesity, overweight, general obesity, hypertension and low levels of education were significantly associated with prediabetes. Conclusions: The epidemic situation of diabetes in northwest China's Gansu province is serious. The distribution of diabetes between different sex, age groups and different ethnic groups were significantly different. More than half of the diabetes patients are undiagnosed, which showed the low hospitalizing rate and the lack of public awareness of diabetes.
Assessment of the simultaneous effect of hypothyroidism and thyroid autoimmunity with gestational diabetes on the incidence of type 2 diabetes
Authors: zahedi Maryam , Kazemian Elham , Tehrani Fahimeh Ramezani , tohidi Maryam , azizi Fereidoun , Khalili Davood , Rahmati maryam , Amouzegar Atieh 
Published: June 2020

Abstract
Introduction: Despite the evidence available on the adverse effects of gestational diabetes (GDM) and thyroid disorders on developing type 2 diabetes (T2DM), the concurrent effect of these disorders on the incidence of T2DM has not been reported yet. Methods: At the initiation of the Tehran Thyroid Study (TTS) non-diabetic women aged 20 to 60 years, with a history of at least one term delivery, who met the inclusion criteria (n=1894) were selected. Pooled logistic regression analyses were used to investigate the association of GDM, thyroid disorders i.e. hypothyroidism (clinical or subclinical) and/or thyroid peroxidase antibody (TPOAb) positivity and interaction between GDM and thyroid disorders with the risk of incident T2DM. Results: Of the 1894 participants of the present study, 346 (18.3%) had a history of GDM, and 832 (43.9%) had thyroid disorders. The total cumulative incidence rate of T2DM at the median follow-up time of ~ 12 years was overall 12/1000 person-years (95% confidence interval (CI): 10/1000–13/1000), with an incidence rate of 16/1000 (95%CI: 13/1000–20/1000) in women with GDM; and 11/100,000 (95%CI: 9/100,000–12/1000) among those without GDM. After adjustment for age, the risk of incident T2DM increased among individuals with the previous GDM compared to women without a history of GDM (odds ratio (OR): 1.54, 95%CI: 1.06, 2.25). No significant associations were found between either thyroid disorders or the interaction between GDM and thyroid disorders with the development of T2DM; (OR: 1.14, 95%CI: 0.82, 1.58) and (OR: 1.27, 95%CI: 0.66, 2.43), respectively.Conclusion: GDM and thyroid disorders have no concurrent effects on the incidence of T2DM.
The effect of practice toward do-not-resuscitate among Taiwanese nursing staff using path modeling
Authors: Wu Li-Fen , Chang Li-Fang , Hung Yu-Chun , Lin Chin , Tzou Shiow-Jyu , Chou Lin-Ju , Pan Hsueh-Hsing 
Published: June 2020

Abstract
Background: Do-Not-Resuscitate (DNR) is signed to prevent patients from receiving invalid treatment at the end of life or near death. Nurses play an important role to discuss the DNR with patients or the patients’ family members. However, research focusing on the relationship between the knowledge, attitude and practice of a DNR using path modeling in nursing staff is limited. Therefore, this study aimed to elucidate the effect of path modeling on the knowledge, attitude, and practice toward DNR among the Taiwanese nursing staff.Methods: This was a cross-sectional, descriptive design using a simple random sampling. Data on demographics, knowledge, attitude, and practice as measured by the DNR inventory (KAP-DNR), Mindful Attention Awareness Scale, General Self-Efficacy Scale, and Dispositional Resilience Scale was collected. Participants were 194 nursing staff from a medical center in northern Taiwan in 2019. We performed descriptive statistics, regression analysis, and path modeling using SPSS 22.0 and set p <0.05 as the statistical significance threshold. Results: The results showed that participation in DNR signature and education related to palliative care were positive significant predictors of knowledge towards DNR. The DNR predictors toward attitude included DNR knowledge, mindfulness, self-efficacy, dispositional resilience, and religious belief of nurses. Generally, the key predictors of DNR practice were DNR attitude, dispositional resilience, and male nurses. In path modeling, we identified that self-efficacy, dispositional resilience, master’s degree, and religious belief directly influenced practices constituting DNR. Conclusion: Based on the findings of this study, it is proposed that nurses should improve their self-efficacy and dispositional resilience. Encouraging staff to undertake further education and have religious beliefs can improve the practice of DNR and provide better end of life care.
Localization of Epileptic Seizure Focus by Computerized Analysis of fMRI Recordings
Authors: Hekmati Rasoul , Azencott Robert , Zhang Wei , Zili Chu , Paldino Michael 
Published: June 2020

Abstract
By computerized analysis of cortical activity recorded via fMRI for pediatric epilepsy patients, we implement algorithmic localization of epileptic seizure focus within one of eight cortical lobes. Our innovative machine learning techniques involve intensive analysis of large matrices of mutual information coefficients between pairs of anatomically identified cortical regions. Drastic selection of pairs of regions with biologically significant inter-connectivity provides efficient inputs for our Multi-Layer Perceptron (MLP) classifier. By imposing rigorous parameter parsimony to avoid overfitting we construct a small size MLP with very good percentages of successful classification.
Attitude towards menstruation by female in-school adolescents: A comparative cross-sectional study in southwest Nigeria
Authors: Aluko Olufemi Oludare , Udechukwu Jireh Ngozi , Loto Oluwaseun Anthonia , Orisawayi Ayoola Oluwaniyi , Ojogba Grace Ojodomo , Arowosafe Promise Oluwaseun 
Published: June 2020

Abstract
Background: Menarche and menstruation are natural procedures in a girl’s transition to womanhood. Lack of awareness thereof, before menarche and stigmatizing menstrual hygiene management (MHM) experiences predominate in low resource economies and influences attitude. The study aims to determine and compare the attitude of adolescents attending public and private schools on menstruation and MHM in the study area.Methods: The cross-sectional study recruited 357 respondents, comprising of 177 and 180 female adolescents from public and private schools through a three-stage sampling technique. The study administered a validated, semi-structured questionnaire that was facilitated self-administered. Descriptive and inferential statistics presented results, while binary logistic regression identified predictors of attitude at Pά0.05.Results: Except for religion, other socio-demographic characteristics (age, class, ethnicity, whom adolescents’ lives with, highest education and wealth) were significantly different between public and private schools. However, respondents in public schools were older (15.4±1.75 years) when compared with those attending private schools (14.3±1.18 years). On attitude, negative feelings and openness scales were significantly different between respondents attending public and private schools, while those of positive feelings, menstrual symptoms, acceptance of menarche and living with menstruation were respectively similar at Pα0.05. Overall attitude scale indicated a higher negative rating (87.4) when compared with a positive score (12.6%). With a positive attitude as a reference, ethnicity was the only negative attitude predictor (Pα0.05).Conclusions: Adolescents attending public and private schools have negative attitudes toward menstruation and MHM. Therefore, awareness and puberty education through ethnic constructs, on menstruation and MHM before menarche is indispensable to improve their attitude.
The rare anatomical variant of upper lobe: clinical features of 46 cases with surgical procedure
Authors: shen cheng , che guowei 
Published: June 2020

Abstract
Background

Primary disease in thorax associated with an azygos lobe is extremely rare. It is usually identified incidentally on chest X-ray or CT during health checkups with an incidence of up to 0.2%. This is the first study involving 46 of patients found with azygos lobe in surgery of English literature from January 1931 to October 2018.
Methods

PubMed, EMBASE and the Web of Science databases were searched for full-text literatures met out inclusion criteria. We summarized the clinical data, radiological manifestation, accompanying disease and treatment strategy of all patients.
Results

18 eligible studies involving 46 patients were selected for this research. The mean age was 36.5 years old. There were 26 male patients and 20 female patients and the male to female ratio nearly to 1.3:1. There were many different primary diseases with azygos lobe including lung cancer (n = 8), spontaneous pneumothorax (n = 5), esophageal cancer (n = 1), pulmonary sequestration (n = 1), esophageal atresia (n = 2), hyperhidrosis (n = 29). The azygos lobe (azygos lobe in Figs. 1 and 2) is an uncommon anomaly that is found in 1% of anatomic specimens, on about 0.4% of chest radiographs and 1.2% of high resolution CT. The azygos lobe is a developmental anomaly but not a true accessory lobe. Azygos lobe of all patients was diagnosed during the operation.
Conclusions

Azygos lobe occurs in 0.2% of the population and can make clinical diagnosis difficult. The detection of this anomaly and clarification of its precise anatomical features are important to alert the surgeon to potential problems during surgery.
Resolution of Calcinosis using Bisphosphonates in Overlap Syndrome – A Case Report
Authors: Platter Mitchell , Pugmire Brian , Patel Reshma 
Published: June 2020

Abstract
Background Calcinosis cutis is a common complication of pediatric rheumatologic diseases. However, there is currently no consensus on first-line treatment. Bisphosphonates have been described as successful treatment in several case studies, but most of these cases are limited to patients with isolated juvenile dermatomyositis or systemic sclerosis. Specifically, there are limited reports of their usefulness in treating overlap syndromes and mixed connective tissue disorders.Case Presentation: We describe the case of a 13 year-old girl with overlap syndrome with mostly features of juvenile dermatomyositis and systemic lupus erythematosus. After 22 months of extensive immunosuppressive therapy, including monthly IVIG, she continued to have pain and weakness of the lower extremities. A CT scan was performed which showed significant multifocal soft tissue calcifications of the pelvis. She was started on treatment with oral alendronate with the goal of improving her calcinosis and improving her symptoms. After several months of therapy, our patient reported subjective improvement of her lower extremity pain and weakness, as well as complete resolution of abnormalities previously seen on physical examination. A repeat CT scan of the pelvis was performed after 11 months of therapy and demonstrated complete resolution of the previously seen calcinosis.Conclusions We report the successful treatment of soft tissue calcinosis with oral bisphosphonates in a patient with juvenile dermatomyositis-systemic lupus erythematosus overlap syndrome. These results provide further evidence that bisphosphonates can be used successfully to treat calcinosis cutis in pediatric rheumatologic disorders. Additionally, the results provide new evidence that they can be used specifically in juvenile dermatomyositis-systemic lupus erythematosus overlap syndrome, which has not been previously reported.
Prevalence of HIV infection among foreign applicant to residency in Shanghai, China, 2005-2016
Authors: Qin Jia , Xia Jing , Zhu Peiqin , Zhou Ru 
Published: June 2020

Abstract
Background

Shanghai is an international city which has high proportion of entry travelers from all over the world. The HIV(human immunodeficiency virus)infection status of this population can reflect the global trend of HIV prevalence. Thus, a retrospective epidemic investigation was conducted to clarify the prevalence and characteristics of HIV infection among entry travelers who apply to residency in Shanghai.

Methods

Totally 50830 entry travelers who applied to residency in Shanghai(2005-2016)were included. The HIV infection rate was confirmed based on the detection of HIV-1 antibody.

Results

Among all the recruited entry travelers, 245 persons were determined HIV positive with infection rate of 0.48%. The detection rate of HIV in male was significantly higher than that in female (χ 2 =62.584, P <0.0001). Those aged 18-30 years, 31-40 years and >40years accounted for 34.3%, 39.6% and 26.1% of the infected population. There was no increase in trend of HIV prevalence rates among the sampling years (Cochran-Armitage Z=2.543, P=0.111). Proportions of individuals infected through homosexual transmission increased over the study period (Cochran-Armitage Z=5.41, P<0.001), while the proportion infected through heterosexual declined over time (Cochran-Armitage Z=3.38, P =0.001).

Conclusion

The rate and characteristics of HIV infection among foreign applicant to residency in Shanghai were clarified in the study. The results would have provided the necessary epidemiological data for monitoring the HIV epidemic among entry international travelers and to further contribute to the establishment of relevant policies and regulations for HIV control and prevention.