bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discriminative validity of the Lower and Upper Quarter Y Balance Test performance: A comparison between healthy trained and untrained youth
Authors: Schwiertz Gerrit , Beurskens Rainer , Muehlbauer Thomas 
Published: October 2020

Abstract
Background: The Lower (YBT-LQ) and Upper (YBT-UQ) Quarter Y Balance Test have been widely used for the assessment of dynamic balance and shoulder mobility/stability, respectively. However, investigations on the validity of the two tests in youth are lacking. Therefore, we performed two studies to determine discriminative validity of the YBT-LQ (study 1) and the YBT-UQ (study 2) in healthy youth.Methods: Sixty-nine male soccer players (age: 14.4 ± 1.9 yrs) and 69 age-matched untrained male subjects (14.3 ± 1.6 yrs) participated in study 1 and 37 young swimmers (age: 12.3 ± 2.1 yrs) as well as 37 age-/sex-matched individuals (age: 12.5 ± 2.0 yrs) took part in study 2. Absolute (cm) and relative (% leg/arm length) maximal reach distances per reach direction and the composite score of the YBT-LQ/UQ were used as outcome measures. One-way analysis of variance and the receiver operator characteristic curve analysis (i.e., calculating the area under the curve [AUC]) were conducted to assess discriminative validity.Results: Concerning the relative values, youth athletes showed significantly better YBT-LQ (study 1: p < 0.001, d = 0.86-1.21) and YBT-UQ (study 2: p < 0.001, d = 0.88-1.48) test performances compared to age- and sex-matched untrained subjects. Further, AUC-values indicated a chance of ≥74% (YBT-LQ) and ≥71% (YBT-UQ) to discriminate between youth athletes and controls. These findings were confirmed when using the absolute data for analysis.Conclusions: According to our results, the YBT-LQ and the YBT-UQ seem to be useful test instruments to discriminate trained and untrained healthy youth performance for dynamic balance and shoulder mobility/stability, respectively.
National Early Warning Score 2 (NEWS2) and 3-Level Triage Scale as Risk Predictors in Frail Older Adults in the Emergency Department
Authors: Kemp Kirsi , Alakare Janne , Harjola Veli-Pekka , Strandberg Timo , Tolonen Jukka , Lehtonen Lasse , Castren Maaret 
Published: October 2020

Abstract
Background The aim of the emergency department (ED) triage is to recognize critically ill patients and to allocate resources. No strong evidence for accuracy of the current triage instruments, especially for the older adults, exists. We evaluated the National Early Warning Score 2 (NEWS2) and a 3-level triage assessment as risk predictors for frail older adults visiting the ED.Methods This prospective, observational study was performed in a Finnish ED. The data were collected in a six-month period and included were ≥75-year-old residents with Clinical Frailty Scale score of at least four. We analyzed the predictive values of NEWS2 and the three-level triage scale for 30-day mortality, hospital admission, high dependency unit (HDU) and intensive care unit (ICU) admissions, a count of 72-hour and 30-day revisits, and ED length-of-stay (LOS). Results A total of 1711 ED visits were included. Median for age, CFS, LOS and NEWS2 were 85 years, 6 points, 6.2 hours and 1 point, respectively. 30-day mortality was 96/1711. At triage, 69, 356 and 1278 of patients were assessed as red, yellow and green, respectively. There were 1103 admissions, of them 31 to an HDU facility, none to ICU.With NEWS2 and triage score, AUCs for 30-day mortality prediction were 0.70 (0.64-0.76) and 0.62 (0.56-0.68); for hospital admission prediction 0.62 (0.60-0.65) and 0.55 (0.52-0.56), and for HDU admission 0.72 (0.61-0.83) and 0.80 (0.70-0.90), respectively.The NEWS2 divided into risk groups of low, medium and high did not predict the ED LOS (p=0.095). There was a difference in ED LOS between the red/yellow and as red/green patient groups (p<0.001) but not between the yellow/green groups (p=0.59).There were 48 and 351 revisits within 72 hours and 30 days, respectively. With NEWS2 AUCs for 72-hour and 30-day revisit prediction were 0.48 (95% CI 0.40-0.56) and 0.47 (0.44-0.51), respectively; with triage score 0.48 (0.40-0.56) and 0.49 (0.46-0.52), respectively.Conclusions The NEWS2 and a local 3-level triage scale are statistically significant, but poor in accuracy, in predicting 30-day mortality, and HDU admission but not ED LOS or revisit rates for frail older adults. NEWS2 also seems to predict hospital admission
Incidence and Risk Factors for High-level BK viruria -A Single Center Study in China
Authors: Xiong Rui , Ye Haimin , Liu Zhujing , Li Xinchang 
Published: October 2020

Abstract
Background BK virus allograft nephropathy (BKVAN) is a serious complication after kidney transplantation, and the effect of pre-emptive intervention for high-level BK viruria has been verified, but protocols after kidney transplantation for early identification of high-level viruria are lacking.Methods This was a single-center study. The clinical data of the kidney transplant recipients and their donors in our center from January 1, 2015 to December 31, 2018, were collected. The patients were divided into the high-level BK viruria group (Group A) and a non-high-level BK viruria group (Group B) according to the qPCR results of BK virus DNA loads in urine samples. Significant variables were screened out by univariate analysis, and then the results were incorporated into a multivariate logistic regression model to analyze the independent risk factors for high-level BK viruria.Results A total of 262 recipients were included in the study. The incidence of high-level BK viruria was 13.4% (n=35), and the median time of detection was 181 (range 91~1119) days. Univariate analysis showed that donor type ( =21.770, P < 0.001), history of ATG/ATG-F application ( =4.543, P=0.033), acute rejection (AR) ( =8.313, P=0.004) and delayed graft function (DGF) ( =21.170, P < 0.001) were related to high-level BK viruria. After the inclusion of the multivariate logistic regression model, the results showed deceased brain and cardiac donors (P=0.032, OR=3.927, 95% CI: 1.122~13.746), AR (P=0.022, OR=4.709, 95% CI: 1.253~17.697) and DGF (P=0.001, OR=6.682, 95% CI: 2.288~19.518).Conclusions Donation by deceased brain and cardiac patients, history of AR and DGF were independent risk factors for high-level BK viruria after kidney transplantation.
Interpersonal trauma and its relation to childhood psychopathic traits: what does ADHD and ODD add to the equation?
Authors: Marshall John , Sorman Karolina , Durbeej Natalie , Thompson Lucy , Lundström Sebastian , Minnis Helen , Hellner Clara , Gillberg Christopher 
Published: October 2020

Abstract
Background
Childhood trauma has demonstrated associations with callous-unemotional traits (e.g., reflecting lack of remorse and guilt, unconcern about own performance). Less is known about associations between trauma and multiple domains of child psychopathic traits. There has also been limited focus on the role of co-occurring disorders to psychopathy traits among children, namely, attention-deficit hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD) and how they interact with childhood trauma.
Methods
We examined to what degree childhood interpersonal trauma can predict parent-rated psychopathic traits in a large population based Swedish twin sample (N = 5057), using a stringent definition of interpersonal trauma occurring before age 10. Two hundred and fifty-one participants met the interpersonal trauma criteria for analysis. The study explored the additional impact of traits of attention-deficit hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD).
Results
Linear regressions demonstrated statistically significant but clinically negligible effects of interpersonal trauma on total and subscale scores of parent-rated psychopathic traits. When exploring interaction effects of ADHD and ODD into the model, the effect increased. There were interaction effects between ODD and trauma in relation to psychopathic traits, suggesting a mediating role of ODD. Having been exposed to trauma before age 10 was significantly associated with higher parent rated psychopathy traits as measured by The Child Problematic Traits Inventory-Short Version (CPTI-SV), however the explained variance was small (0.3–0.9%).
Conclusions
The results challenge the notion of association between interpersonal trauma and youth psychopathic traits. They also highlight the need to gain an improved understanding of overlap between psychopathic traits, ADHD and ODD for clinical screening purposes and the underlying developmental mechanisms.
Care for neonates in Haiti’s health system: outcomes and lessons
Authors: Dev Alka , Casseus Michelucia , Baptiste Wilhermine Jean , Winter Emma Le , Simpher Katie , Werbel Alice , Joseph Patrice , Wright Peter 
Published: October 2020

Abstract
Background

The rate of facility births in Haiti has doubled over the past two decades, but without comparable reductions in maternal or neonatal mortality. To care for newborns requiring hospitalization in Haiti, we worked with the public health leadership in the Haitian department of the South (Sud) to establish a ward for compromised neonates in a large public hospital with over 3000 annual deliveries but no neonatal care capacity.
Methods

Significant investments were made in establishing basic neonatal services, training nurses, installing and managing a supply chain, and strengthening infrastructure. We present outcomes for 1399 neonates admitted to the ward during the first two years of operation.
Results

Two-thirds of admissions were made from the hospital’s maternity ward after birth, while the remaining babies were born at home or at referring facilities. Inborn neonates had better rates of hospital survival than those born elsewhere; they were also more likely to be born via cesarean section and to be admitted immediately following birth. Babies born elsewhere were more likely to die during their hospital stay. There were no differences between the proportion of premature or low-birth-weight babies born at the hospital or elsewhere. Nursing care proved to be a critical part of the care delivery system.
Conclusions

To support maternal and newborn care, we conclude that integrated, high-frequency nursing training is necessary for both maternity and neonatal nurses. Resources are needed to address prematurity as an important outcome, especially as it is indicative of poor prenatal care, regardless of place of birth.
Hemostatic Effect and Safety of TXA: An Umbrella Review
Authors: Jiang Mingyang , Deng Huachu , Liu Siyi , Xie Xiaoyong , Bo Zhandong 
Published: October 2020

Abstract
Aim

To evaluate the hemostatic effect and safety of tranexamic acid (TXA).
Methods

Meta-analyses were retrieved from databases. Risk ratios (RR), odds ratios (OR), weighted mean difference (WMD), standard mean difference (SMD) and 95% confidence intervals (CI) were extracted to compare the effeteness of TXA in reducing TBL, transfusion rate, Hb drop, mortality, DVT, PE.
Results

In total, 136 trials (396 comparisons) including 17 kinds of surgeries were retrieved. The evidence for TXA using in total knee arthroplasty (TKA), total hip arthroplasty (THA), postpartum bleeding, intertrochanteric fractures, orthopaedic surgery, spinal surgery, shoulder arthroplasty, hip fracture surgery, cardiac surgery, menstrual bleeding, plastic surgery, myomectomy, nasal surgery was assessed as possible for the association of reducing TBL. The evidence for TXA using in TKA, THA, postpartum bleeding, orthopaedic surgery, shoulder arthroplasty was assessed as probable for the association of reducing transfusion rate. The evidence for TXA using in liver surgery, spinal surgery, hip fracture surgery, cancer, cardiac surgery was considered to be possible for the association of reducing transfusion rate. The evidence for TXA using in intertrochanteric fractures, orthopaedic surgery, hip fracture surgery was assessed as probable for the association of reducing Hb drop. The evidence for TXA using in TKA, THA, postpartum bleeding, shoulder arthroplasty was considered to be possible for the association of reducing Hb drop. The evidence for TXA using in trauma, gastrointestinal bleeding was assessed as probable for the association of reducing mortality.
Conclusion

This umbrella review indicated that TXA were regarded as effective to reduce TBL, transfusion rate, Hb drop, mortality, and did not increase the incidence of DVT and PE. However, more convincing evidence should be provided to further clarify the level of efficacy and safety of TXA.
Latent Profiles of Patients with Borderline Pathology Based on the Alternative DSM-5 Model for Personality Disorders
Authors: Gamache Dominick , Savard Claudia , Leclerc Philippe , Payant Maude , Côté Alexandre , Faucher Jonathan , Lampron Mireille , Tremblay Marc 
Published: October 2020

Abstract
Background

There have been multiple attempts to try to parse out heterogeneity within borderline pathology by identifying patient subtypes; thus far, these works have yielded few consistent results. Recent developments in the operationalization of borderline pathology may provide new opportunities to identify clinically and conceptually meaningful subgroups of patients. The Alternative DSM-5 Model for Personality Disorders (AMPD) offers a categorical-dimensional operationalization of Borderline personality disorder (BPD) that has yet to be tested for identification of patient subgroups. The purpose of the present study is to test whether the combination of the Criterion A elements (pertaining to level of severity) and the seven pathological traits from Criterion B that define BPD in the AMPD can yield meaningful patient profiles.
Methods

A total of 211 outpatients from a specialized PD treatment program (133 women, Mage = 33.66, SD = 10.97) were selected based on the presence of at least moderate borderline pathology according to cutoffs recently proposed for the Borderline Symptom List-23. Valid Criterion A (Self and Interpersonal Functioning Scale) and B (Personality Inventory for DSM-5-Short Form) self-reports were administered to measure elements and traits that define BPD in the AMPD model; these variables were used as indicators in a Latent profile analysis (LPA).
Results

The optimal solution generated by LPA yielded four distinct profiles: (a) Borderline traits; (b) Low borderline pathology with Impulsivity; (c) Moderate borderline pathology with Identity problems and Depressivity; and (d) Severe borderline pathology. Clinically meaningful distinctions emerged between profiles on AMPD indicators and external variables relevant to PD, especially aggression and impulsivity.
Conclusions

Profiles reflected both the “severity” and “style” components imbedded within Criterion A and B of the AMPD, as they were mainly distinguished by a continuum of severity but also by some meaningful qualitative differences that may have important clinical implications for treatment planning and contracting. Results also suggest that the four Criterion A elements have independent value to identify important differences in patients with borderline pathology. They also highlight that some Criterion B traits that define BPD in the AMPD may be especially important to identify subgroups of patients, mainly Impulsivity and Depressivity.
Modified Taohong Siwu Decoction Improved Heart Function After Myocardial Infarction by Inhibiting Inflammatory Factor and Promoting Chemotactic and Pro-Angiogenic Factors
Authors: Luo Zhi-rong , Li Han , Xu Yan-wu , Xuan Shou-song , Cai Hao , Wang Lei , Guo Hai-dong 
Published: October 2020

Abstract
BackgroundTraditional Chinese medicine has been applied to prevent and treat myocardial infarction (MI) in the clinic for a long history. We recently found that Taohong Siwu decoction (THSWD) exerted a beneficial effect on heart function after MI through improving the local hostile microenvironment. However, the improvement of cardiac function after THSWD administration was moderate. In this study, four Chinese medicine herbs, which have the properties of warming Yang or removing phlegm, were added into THSWD to constitute a new and multifunctional Chinese herbal compound, named modified THSWD (MTHSWD). MethodsA rat model of MI was established by the ligation of left anterior descending coronary artery and MTHSWD was intragastrically administered for 2 weeks. The heart function was examined by echocardiography, cell apoptosis was detected by TUNEL staining and the infarct size was determined by Masson's trichrome staining. The expressions of cytokines, including chemotactic and inflammatory factors, were examined by ELISA in the infarcted myocardium and serum. The level of p-Akt and VEGF in the damaged myocardial tissues was further detected by Western blot. ResultsMTHSWD improved heart function and decreased infarct size and collagen deposition in the infarcted area. In addition, MTHSWD increased the expression of cTnT and Cx43, reduced cell apoptosis in the infarcted area by activating Akt signal and promoted angiogenesis by increasing the expression of VEGF. Interestingly, MTHSWD significantly increased the level of IGF-1, SDF-1 and TNF-α, and significantly reduced the expression of IL-1β in the infarcted myocardium. MTHSWD could also significantly increase the expression of IGF-1, SDF-1 and SCF in the serum. ConclusionsMTHSWD reduced cell apoptosis, promoted angiogenesis and improved heart function after MI probably through the downregulation of inflammatory factor IL-1β, upregulation of chemotactic factors SDF-1 and SCF as well as pro-angiogenic factor VEGF, and activation of Akt signaling pathway.
Synergistic Effect of Genetic Polymorphisms in TLR6 and TLR10 Genes on The Risk of Pulmonary Tuberculosis in Moldavian Population
Authors: Varzari Alexander , Deyneko Igor V. , Tudor Elena , Grallert Harald , Illig Thomas 
Published: October 2020

Abstract
BACKGROUND: Host immunity is essential for efficient recognition and clearance of M. tuberculosis infection. Polymorphisms in genes that regulate immune response have been reported to influence the susceptibility/resistance to pulmonary tuberculosis (TB). Here we evaluated associations between 14 polymorphisms in 12 core genes involved in immune responses and pulmonary TB in Moldavian population, and investigated whether interactions between these and previously analyzed polymorphisms could exist and modulate the risk of pulmonary TB.METHODS: Polymorphisms VDR rs7975232, VDR rs1544410, VDR rs2228570, MR1 rs1052632, TLR1 rs5743618, TLR2 rs111200466, TLR10 rs11096957, SLC11A1 rs2276631, IL1B rs1143643, IL10 rs1800896, IFNG rs2430561, TNF rs1800629, IRAK1 rs1059703, and FOXP3 rs2232365 were genotyped in 271 Moldavian pulmonary TB cases and 251 community-matched healthy controls. Associations were tested using Fisher test and logistic regression. Complemented with the data from our previous study (PMID: 30529560), investigation of gene-gene interactions was performed for a total of 43 loci. Significance level was adjusted by the Bonferroni correction.RESULTS: Single polymorphism analysis revealed a nominal association between TNF rs1800629 and pulmonary TB (Fisher exact test p-value = 0.01843). Marginal differences between cases and controls were observed for haplotypes in the gene cluster TLR1-TLR6-TLR10 and gene TLR2. In the pairwise interaction analysis, the combination of genotypes TLR6 rs5743810 GA and TLR10 rs11096957 GT was significantly associated with an increased genetic risk of pulmonary TB (OR = 2.48, 95% CI = 1.62–3.85; Fisher exact test p-value = 1.5 x 10-5, significant after Bonferroni correction).CONCLUSION: The TLR6 rs5743810 and TLR10 rs11096957 two-locus interaction confers a significantly higher risk for pulmonary TB and has potential as a novel biomarker for predicting TB susceptibility.
CT Imaging Characteristics Correlated with Overall Survival Time in Patients with AIDS-Related non-Hodgkin’s Lymphoma
Authors: Li Xueqin , Pan Ziang , Zheng Meizhu , Hu Tianli , Wang Xing , Li Li , Ye Wen , Jiang Dongmei , Liu Song , Tang Ruowei , Qi Ziyu , Shen Wen , Liu Jinxin , Shi Yuxin , Xia Shuang , Li Hongjun 
Published: October 2020

Abstract
Background CT can provide useful information for treatment regimens and prognosis prediction of patients with AIDS-related non-Hodgkin’s lymphoma (AR-NHL). It is necessary to investigate the prediction of CT imaging and clinical characteristics for overall survival (OS) in patients with AR-NHL.Methods Data of 121 AR-NHL patients [median age: 41 (range 22-78), 112 male] between July 2012 and November 2019 were retrospectively reviewed. Patients were divided into two groups by median OS time and data were compared between two groups. K-M survival analysis and Cox proportional hazards regression analysis were used to determine the prognostic risk factors for OS.Results The median OS time was 17 months. In the K-M survival analysis, presence of extracapsular infiltration (p=0.032), necrosis (p=0.005), CD4 ≤ 100 cells/μL (p=0.020), period from finding mass to admission﹥1 month (p=0.013), without chemotherapy (p﹤0.001), liver involved (p﹤0.001), gastrointestinal tract involved (p=0.015) and mediastinal or hilar lymph nodes involved (p=0.022) were associated with shorter OS. In the multivariate Cox regression analysis, liver involved (HR=2.48, 95%CI 1.45–4.25, P=0.001), mediastinal or hilar lymph nodes involved (HR=1.70, 95%CI 1.02–2.83, P=0.042), necrosis in lesion (HR=2.02, 95%CI 1.21–3.36, P=0.007) and CD4 ≤ 100 cells/μL (HR=2.66, 95%CI 1.42–4.98, P=0.002) were independently risk factors for shorter OS. Chemotherapy (HR=0.48, 95%CI 0.26–0.89, P=0.020) was independently protective factor for shorter OS. The predictive models based on Cox regression has good discrimination (Harrell’s C-index=0.716) and good calibration (Hosmer-Lemeshow test, p=0.620). Conclusion When the tumor had necrosis and extracapsular infiltration, involvement of mediastinal or hilar lymph nodes, liver, gastrointestinal tract in CT images, the overall prognosis was poor. And intensive chemotherapy regimens and more frequent follow-up should be considered.
Primary sinonasal renal cell-like adenocarcinoma: a case report and review of the literature
Authors: Gou Xiaoxia , Wang Yanzhe , Chen Fang , Liu Xiaoli , Ruan Peigang , Tian Xin , Wu Jinzhi , Ma Hu 
Published: October 2020

Abstract
BackgroundPrimary sinonasal renal cell-like adenocarcinoma (SNRCLA) is an extremely rare neoplasm with unique clinical and pathological features. At present, there is no summary of its clinical and pathological characteristics. We treated one case and reported to here. Review the domestic and foreign literature, summarize its clinical pathological characteristics and diagnosis and treatment.CaseA 69-year-old female presented with repeated epistaxis, nasal obstruction of 2-years’ duration. Computed tomography (CT) was performed revealing an irregular mass of the right nasal cavity involving choana and nasopharynx. The patient was treated with endonasal endoscopic resection. Histologically, SNRCLA was very similar to clear cell renal cell carcinoma (RCC), the tumor cells were round or polygonal in size with abundant clear cytoplasm and uniform nuclei. The tumor cells positive for CK7, Vimentin, EMA, S-100, Ki-67 (5% +) and negative for CEA, P53, P63 by immunohistochemical staining,. The patient is free from recurrence over 27 months after the surgery.ConclusionSNRCLA seems to be a low-grade localized carcinoma associated with favorable prognosis. Surgical resection is recommended as the main stay of treatment.