bluuebunny/crossref_metadata_2025_split huggingface dataset:
Análises dos indicadores físico-químicos, microbiológicos e parasitológicos de contaminação ambiental em amostras de água da Lagoa Mundaú, em Alagoas
Authors: Mendes Newton César de Lima , Lessa Ana Gabrielle de Barros , Martins Isabelle Cavalcante , Ferreira Júnior Genildo Cavalcante , Costa Hyngrid Assíria Amorim , Miranda Paulo Rogério Barbosa de , Rocha Thiago José Matos 
Published: July 2020

<p>O presente estudo teve como objetivo principal analisar as propriedades físico-químicas (pH, temperatura, amônia, nitrato e oxigênio dissolvido) e fazer análises microbiológica e parasitológica em amostras de água da Lagoa Mundaú, em Alagoas. Todas as análises foram realizadas no Laboratório de Pesquisa do Centro Universitário Cesmac e no Laboratório Central Analítica Alagoas Ltda., através de equipamentos clássicos e <em>kits</em> alternativos. Foram observados os seguintes resultados com relação aos parâmetros físico-químicos analisados: pH 7,29 ± 0,395, amônia 12,22 ± 1,74 mg/L, nitrito 0,0105 ± 0,001 mg/L, nitrato 0,199 ± 0,092 mg/L e oxigênio dissolvido (OD) médio de 5,136 ± 1,031 mg/L. A partir das análises microbiológicas da qualidade da água da Lagoa Mundaú, observa-se que esta apresentou resultados preocupantes e insatisfatórios quanto a condições propícias para a balneabilidade, tendo em vista que, em todas as amostras (100%) de água analisadas, observou-se a presença de coliformes totais e <em>Escherichia coli</em>. As análises parasitológicas não revelaram a presença de nenhum parasito de importância médica.</p>
Fertilização organomineral e águas salinas na produção de fitomassa de Capsicum annuum
Authors: Mesquita Francisco De Oliveira , Souto Antônio Gustavo Luna , Diniz Adriana Araújo , Alves Jackson De Mesquita , Lima Alex Serafim de , Japiassú André , Azevedo Francisco Roberto de 
Published: July 2020

<p>Um experimento foi executado em casa de vegetação, no período de março a abril de 2018, no município de Crato-CE, com o objetivo de avaliar os efeitos de biofertilizantes (comum e rico quimicamente) em substrato irrigado com diferentes composições de águas salinas sobre a produção de fitomassa de mudas de pimentão amarelo, variedade Sucesso (952). O experimento foi desenvolvido utilizando um material ou substrato dos primeiros 20 cm de um Latossolo Vermelho-Amarelo. O delineamento experimental foi inteiramente casualizado em esquema fatorial 5 x 3, com três repetições, referentes aos valores de condutividade elétrica da água (CEa) de irrigação 0,5; 1,0; 2,0; 3,0 e 4,0 dS m<sup>-1</sup>, no solo sem o insumo orgânico, no solo com biofertilizante comum e, ainda, no solo com biofertilizante rico, totalizando 45 tratamentos, acondicionados em sacos de polietileno preto com capacidade máxima de 3,0 kg. O biofertilizante, depois de diluído na proporção de 3:1, foi aplicado uma única vez a 10% do volume do substrato, dois dias antes da semeadura. A irrigação com águas salinas afetou a morfologia e a qualidade de mudas de pimentão amarelo (cv. Sucesso), mas com menor intensidade nos tratamentos que receberam o insumo orgânico comum e o rico, respectivamente.</p>
Descrição biométrica de plantas e dos atributos quanti-qualitativos de frutos de icozeiro (Capparis yco) procedentes de áreas espontâneas no semiárido paraibano
Authors: Dias Cícero Silva , Freire José Lucínio De Oliveira , Arruda Jandeilson Alves de 
Published: July 2020

The icozeiro (Capparis yco) is an endemic plant in the northeastern Brazil, with spontaneous access occurring in micro regions of the semi-arid region of Paraíba. However, there is practically no information about the plant or the characterization of its fruits from Curimataú in Paraíba. Based on that, this research aimed to describe the biometric characteristics of plants and the physical and chemical attributes of icozeiro fruits coming from spontaneous accesses. In plants, the variables evaluated were the following: height, stem diameter, crown diameter, leaf length and width, length of floral rachis, number of flowers per panicle and number of fruits. In the fruits, the physical characters were analyzed (equatorial diameter and length, total fresh mass, peel mass, seed mass, pulp mass, number of seeds, percentage of peel, percentage of peel, peel thickness and pulp yield), and chemical attributes (contents of soluble solids and pH). The plants presented average heights of 2.7 ± 0.8 m. Average canopy diameter was 2.4 ± 1.0 m, and average floral rachis length was 10.8 ± 4.9 cm and between 3.0 and 58.0 flowers per panicle. Analysis of fruits indicated an average mass of 77.7 ± 35.7 g, 12 ± 7.2 seeds per fruit, average pulp yield of 44.1 ± 8.5%, soluble solids between 11.0 oBrix and 33.0 oBrix and pH between 3.3 and 6.4. The icozeiro has a low medium size, being characterized as a shrubby plant, resistant to the edaphoclimatic weather of the region, remaining green, producing flowers and fruits in periods of drought. With regards to fruits, they presented aspects that are compatible with the requirements for industrial processing and fresh consumption in the domestic consumer market, which does not impede studies about their processing. Considering results presented and the domestic market, fresh consumption can be advantageous.
Utilização de água residuária tratada na recuperação da fertilidade de solo degradado no semiárido paraibano
Authors: Martins Emanoel Lima , Fraga Vânia Da Silva , Medeiros Salomão De Sousa 
Published: July 2020

<p class="Normal1"><span>O objetivo deste estudo foi avaliar o efeito da aplicação de água residuária tratada na recuperação dos teores de matéria orgânica e fósforo em um solo degradado na região semiárida. Foi realizado um experimento com irrigação de cinco espécies florestais da caatinga, no qual foram aplicados três tratamentos que consistiram na variação do tipo e do volume de água aplicados ao solo: 7 L por semana de água de abastecimento; 7 L por semana de água residuária; e 14 L por semana de água residuária. Após decorridos dois anos de irrigação, foram retiradas amostras do solo e analisadas quanto aos teores de matéria orgânica e fósforo. O teor de matéria orgânica no tratamento com aplicação de 14 L de água residuária em relação à aplicação de água de abastecimento foi cinco vezes superior na camada superficial e oito vezes na subsuperficial, respectivamente. A partir dos resultados encontrados, pode-se considerar que a utilização de água residuária de esgotos domésticos tratados é uma alternativa para a recuperação da capacidade produtiva do solo, pelo incremento nos teores de matéria orgânica e fósforo. A irrigação com água residuária tratada pode proporcionar incremento elevado nos teores de matéria orgânica e fósforo no solo até os 30 cm de profundidade.</span></p>
La uretro-vesico suspensión de Marshall - Marcheti - Krantz en la corrección de la incontinencia urinaria de esfuerzo
Authors: Bernal Enrique 
Published: July 2020

La incontinencia urinaria de esfuerzo en la mujer es una afección común y embarazosa generalmente atribuible al menos en parte, a alguna forma de traumatismo en el momento del parto. Su relación con el prolapso vaginal y uterino es inconstante.
Comunicación preliminar sobre un caso de agenesia de vagina con doble útero unicorne
Authors: Luna Uribe Joaquín 
Published: July 2020

Hemos querido aprovechar la oportunidad de este V Congreso de Obstetricia y Ginecología para presentar este caso de agenesia de vagina con doble útero unicorne, en el que empleamos para la elaboración de la vagina el método de doble tunelización de Sheares ; y al encontrarnos en la laparotomía con un doble útero resolvimos emplear una modificación de la tuboimplantación uterina de Strassmann , que este autor ideó para tratar los casos de atresia de la cavidad uterina.
La culdoscopia como método auxiliar de diagnóstico en ginecología. Presentación de 70 casos
Authors: Del Corral Fernando , Artuz Antonio , Guzmán Carlos A. 
Published: July 2020

La evolución constante de la medicina contemporánea ha llevado al médico en busca de nuevos instrumentos y métodos de ayuda que le permitan llegar a un diagnóstico correcto con un mínimo de molestias y complicaciones. Ejemplo de ésto es el aporte que hizo a la ginecología el doctor Albert Decker (1), quien en 1942 introdujo un nuevo instrumento diagnóstico, el culdoscopio y su método de ampliación.
El parto vaginal en paciente con antecedente de cesárea
Authors: Acuña Díaz José Gabriel 
Published: July 2020

A pesar de los numerosos estudios publicados sobre el tema, respaldados en largas series de casos, existen aún divergencias sobre la conducta a seguir en la paciente con antecedente de cesárea. Por esta razón emprendimos en el Instituto Materno Infantil Concepción Villaveces de Acosta una revisión del tema. Presentamos los resultados obtenidos en los casos estudiados en un lapso de 19 meses, comprendido entre el mes de septiembre de 1962 y el mes de marzo de 1964.
Manejo de la sonda vesical en el post-operatorio de cirugía vaginal
Authors: Guzmán Rubén Darío 
Published: July 2020

En la micción participan elementos importantes como son el sistema nervioso, la uretra posterior en el hombre y toda la uretra, excepto el centímetro más distal en la mujer, además de la vejiga. La pared abdominal y el piso pélvica desempeñan papel aunque en menor grado.
MANAJEMEN KURIKULUM PAUD DI LINGKUNGAN PESANTREN (ANALISIS DI TAMAN KANAK-KANAK ISLAM AL ITTIFAQIAH INDRALAYA SUMATERA SELATAN)
Authors: Muharrahman Muharrahman 
Published: July 2020

Tujuan dari penelitian ini adalah untuk mengetahui: (1) bagaimana implementasi manajemen kurikulum PAUD di lingkungan Pesantren Al Ittifaqiah. (2) sejauhmana keterlibatan yayasan, guru, orang tua dan masyarakat sekitar dalam mendisain dan merencanakan kurikulum PAUD di lingkungan Pesantren Al Ittifaqiah. (3) problematika apa saja yang dihadapi dalam manajemen kurikulum PAUD di lingkungan Pesantren Al Ittifaqiah. Adapun hasil penelitian ini menunjukkan bahwa implementasi kurikulum PAUD di Pesantren Al Ittifaqiah Indralaya meliputi: (1) Perencanaan, terdiri dari: Program Tahunan (Prota), Program Semester (Prosem), Rencana Kegiatan Mingguan (RKM), dan Rencana Kegiatan Harian (RKH). (2) Pelaksanaan. a) Kegiatan keagamaan, meliputi: Menghafal doa seharihari dan surat-surat pendek, Shalat dhuha, Menonton film kartun religi, Manasik haji, dan Bahasa Arab dasar. b) Pengetahuan umum dan seni, meliputi: Pengenalan rambu-rambu lalu lintas, Membuat alat komunikasi (telepon), dan menari. (3) Pengawasan. a) Pengawasan yayasan ke sekolah, meliputi: Observasi sekolah, Pertemuan kelompok, dan Pembicaraan individual. b) Pengawasan kepala sekolah ke para guru, meliputi: Praktek (demonstrasi) mengajar, Observasi kelas, Pembicaraan individual, dan Pertemuan kelompok. (4) Evaluasi. Dilaksanakan setiap akhir tahun pelajaran dengan model evaluasi CIPP, yang meliputi: context, input (anak, pendidik, dan sarana prasarana), process, dan product. Disain dan perencanaan kurikulum melibatkan beberapa pihak, yaitu: Yayasan, Guru, orang dan masyarakat sekitar. Problematika dalam manajemen kurikulum PAUD di lingkungan pesantren Al Ittifaqiah Indralaya yaitu: a) Kompetensi pendidik. b) Sarana dan prasarana (Alat Permainan Edukatif dan ruang atau gedung penunjang).
Identification of an Autophagy-Related Gene Signature that Can Improve Prognosis of Hepatocellular Carcinoma Patients
Authors: Huo Xingxing , Qi Jian , Huang Kaiquan , Bu Su , Yao Wei , Chen Ying , Nie Jinfu 
Published: July 2020

Abstract
Background: Autophagy is a programmed cell degradation mechanism that has been associated with several physiological and pathophysiological processes, including malignancy. Improper induction of autophagy has been proposed to play a pivotal role in the progression of hepatocellular carcinoma (HCC). Methods: Univariate Cox regression analysis of overall survival (OS) was performed to identify risk-associated autophagy-related genes (ARGs) in HCC data set from The Cancer Genome Atlas (TCGA). Multivariate cox regression was then performed to develop a risk prediction model for the prognosis of 370 HCC patients. The multi-target receiver operating characteristic (ROC) curve was used to determine the model’s accuracy. Besides, the relationship between drug sensitivity and ARGs expression was also examined. Results: A total of 62 differentially expressed ARGs were identified in HCC patients. Univariate and multivariate regression identified five risk-associated ARGs ( HDAC1, RHEB , ATIC, SPNS1 and SQSTM1 ) that were correlated with OS in HCC patients. Of importance, the risk-associated ARGs were independent risk factor s in the multivariate risk model including clinical parameters such as malignant stage (HR=1.433, 95% CI=1.293-1.589, P<0.001). In addition, the area under curve for the prognostic risk model was 0.747, which indicates the high accuracy of the model in prediction of HCC outcomes. Interestingly, the risk-associated ARGs were also correlated with drug sensitivity in HCC cell lines. Conclusions: We developed a novel prognostic risk model by integrating the molecular signature and clinical parameters of HCC, which can effectively predict the outcomes of HCC patients.
Functional polymorphisms and transcriptional analysis in the 5' region of the human serotonin receptor 1B gene (HTR1B) and their associations with psychiatric disorders
Authors: Xia Xi , Ding Mei , Xuan Jin-feng , Xing Jia-xin , Yao Jun , Wu Xue , Wang Bao-jie 
Published: July 2020

Abstract
Background The 5-hydroxytryptamine 1B receptor (5-HT1B) plays an essential role in the serotonin (5-HT) system and is widely involved in a variety of brain activities. HTR1B is the gene encoding 5-HT1B. Genome-wide association studies have shown that HTR1B polymorphisms are closely related to multiple mental and behavioral disorders; however, the functional mechanisms underlying these associations are unknown. This study investigated the effect of several HTR1B haplotypes on regulation of gene expression in vitro and the functional sequences in the 5' regulatory region of HTR1B to determine their potential association with mental and behavioral disorders.Methods Six haplotypes consisting of rs4140535, rs1778258, rs17273700, rs1228814, rs11568817, and rs130058 and several truncated fragments of the 5' regulatory region of HTR1B were transfected into SK-N-SH and HEK-293 cells. The relative fluorescence intensities of the different haplotypes and truncated fragments were detected using a dual-luciferase reporter assay system.Results Compared to the major haplotype T-G-T-C-T-A, the relative fluorescence intensities of haplotypes C-A-T-C-T-A, C-G-T-C-T-A, C-G-C-A-G-T, and C-G-T-A-T-A were significantly lower, and that of haplotype C-G-C-A-G-A was significantly higher. Furthermore, the effects of the rs4140535T allele, the rs17273700C-rs11568817G linkage combination, and the rs1228814A allele made their relative fluorescence intensities significantly higher than their counterparts at each locus. Conversely, the rs1778258A and rs130058T alleles decreased the relative fluorescence intensities. In addition, we found that regions from -1587 to -1371 bp (TSS, +1), -1149 to -894 bp, -39 to +130 bp, +130 to +341 bp, and +341 to +505 bp upregulated gene expression. In contrast, regions -603 to -316 bp and +130 to +341 bp downregulated gene expression. Region +341 to +505 bp contained the core promoter region and played a decisive role in gene transcription.Conclusions HTR1B 5' regulatory region polymorphisms have regulatory effects on gene expression and potential correlate with several pathology and physiology conditions. This study suggests that the core promoter sequence of HTR1B is located in region +341~+505 bp. Regions -1587 to -1371 bp, -1149 to -894 bp, -603 to -316 bp, -39 to +130 bp, and +130 to +341 bp contain functional sequences that can promote or suppress the HTR1B gene expression.
Effects of Keluoxin Capsule Combined with Losartan Potassium on Diabetic Kidney Disease with Qi and Yin Deficiency and Blood Stasis Syndrome: Study Protocol for a Randomized Double-Blind Placebo-Controlled Multicenter Clinical Trial
Authors: Wu Rui , Wei Junping , Wei Fan , Qu Lianlian , Bai Litao , Li Jun , Li Fei , Yan Weitian , Wang Qiuhong 
Published: July 2020

Abstract
Background: Diabetic kidney disease (DKD) is one of the most important microvascular complications of diabetes, and its prevalence has increased dramatically in the past few decades. DKD is responsible for considerable morbidity and mortality of patients with diabetes. Keluoxin capsule (KLX) is a Chinese patent medicine that has been used in the clinic to control DKD for years. Thus, we aim to evaluate whether losartan potassium combined with KLX is more effective than losartan potassium in DKD treatment and to provide validated evidence for the application of KLX in the treatment of DKD.Methods: We will conduct a randomized double-blind placebo-controlled multicenter clinical trial. A total of 252 participants diagnosed with DKD recruited from 18 institutions will be randomly allocated to either a KLX treatment group (n=126) or a placebo control group (n=126). The participants will be administered KLX or placebo in addition to losartan potassium for 24 weeks. The primary outcome measure will be the decline in the estimated glomerular filtration rate (eGFR; ml/min/1.73 m2/year) from baseline within 24 weeks, and the secondary outcomes will be the incidence of serum creatinine doubling, the incidence of end-stage renal disease (ESRD), the proportion of subjects with a progressive decline in eGFR >30%, the percent change in 24 h urinary total protein (UTP), the change in the urinary albumin/creatinine ratio (UACR), and the traditional Chinese medicine (TCM) syndrome scale scores.Discussion: This study will be the first randomized clinical trial to evaluate the efficacy and safety of KLX versus placebo for the treatment of patients with DKD. The outcome of this trial will provide a basis for prescribing KLX to patients with DKD.Trial registration: The trial was registered at Chinese Clinical Trial Registry (www.chictr.org.cn) under approval number ChiCTR1900021113 (approval date: 2019/01/29).
Bioinformatics analysis reveals key genes and pathways that promote melanoma metastasis
Authors: su wenxing , guan yi , huang biao , wang juanjuan , wei yuqian , zhao ying , Jiao qingqing , ji jiang , yu daojiang , Xu Longjiang 
Published: July 2020

Abstract
Melanoma has the highest mortality rate of all skin tumors, and metastases are the major cause of death from it. The molecular mechanism leading to melanoma metastasis is currently unclear. With the goal of revealing the underlying mechanism, three data sets with accession numbers GSE8401, GSE46517 and GSE7956 were downloaded from the Gene Expression Omnibus (GEO) database. After identifying the differentially expressed gene (DEG) of primary melanoma and metastatic melanoma, three kinds of analyses were performed, namely functional annotation, protein‐protein interaction (PPI) network and module construction, and co-expression and drug-gene interaction prediction analysis. 41 up-regulated genes and 79 down-regulated genes were selected for subsequent analyses. Results of pathway enrichment analysis showed that extracellular matrix organization and proteoglycans in cancer are closely related to melanoma metastasis. In addition, seven pivotal genes were identified from PPI network, including CXCL8, THBS1, COL3A1, TIMP3, KIT, DCN, and IGFBP5, which have all been verified in the TCGA database, but only CXCL8, THBS1 and KIT had significant differences in expression. To conclude, CXCL8, THBS1 and KIT may be the key genes in the metastasis of melanoma and thus may be regarded as therapeutic targets in the future.
Clinical features of 35 COVID-19 patients with hospitalization for more than 20 days
Authors: Zhang Yiling , Zhang Cheng , Yao Hongmei , Zhao Li , Hu Ying , Zeng Xianchun , Huang Jia , Zhang Peibei , Liu Weijia , Ye Xianwei , Zhang Xiangyan 
Published: July 2020

Abstract
Background: As we know, some patients with Coronavirus disease 2019 (COVID-19) may stay longer in the hospital, but whether the different hospitalization days are associated with different clinical features is not clear yet. Methods: This study is a single-centered, observational and retrospective case series.97 patients with COVID-19 were divided into two groups:patients with hospitalization for more than 20 days (Group1,n=35)and those with hospitalization for less than 20 days (Group2,n=62).Data were collected Results Acute Respiratory Distress Syndrome(ARDS) and Hospital acquired pneumonia (HAP)were more common in Group1 than in Group2 . There were more patients administered quadruple antiviral therapy in Group1 than in Group2 . In group1, 14.3% patients’ specimens showed positive again after they were discharged from the hospital.Compared with Group2,Group1 had higher percentages of oxygenation index<300mmHg leucopenia and lymphopenia. In Group1, 19 patients were treated with chloroquine phosphate,whose nucleic acid tests were negative soon,but 5 patents who hadn’t used the medicine had positive testing again . Conclusions: COVID-19 patients with longer hospitalization are more severe and need more quadruple antiviral therapy ;For patients who don't use chloroquine phosphate, the nucleic acid tests are more likely to return to positive again even if they have no symptoms at that time .
Quasi-liquid crystals of electrons and positrons
Authors: Balzo Gianluigi Zangari del 
Published: July 2020

Abstract
This work concerns the discovery of a time-domain "anomaly" in the Infra-Red synchrotron radiation spectra emitted by electrons and positrons from both the DA NE -Factory (Frascati National Laboratories, Italy) and HFL (Hefei Light Source at NSRL(National Synchrotron Radiation Laboratory, People’s Republic of China). The study was conducted with the SHT unconventional statistical category calculus system, developed and patented by the present author for the analysis of complex systems. The anomaly found in the IR synchrotron radiation emission profile of each single bunch of electrons and positrons, has been resolved by SHT analysis in two distinct waveform components, one of which is "delayed" by a few hundred of ps with respect to the other. A detailed and in-depth analysis excludes that the anomaly is the result of systematic errors The measured time differences between the two signals leads to an apparent discrepancy in the value of the speed of light in a vacuum. A deep time series analysis of the anomaly, based on considerations on the coherent emission of synchrotron radiation (CSR), demonstrates the existence of a distribution of structures and degrees of freedom inside a bunch of particles. This evidence is in contrast with the "rigid bunch" model (J. Schwinger 1945). We therefore pro- pose a model called "CFNM" (Coherent Fractal Nematic Mesophase), which describes the transition from a phase of maximum symmetry to a condensed phase, homologous to the nematic mesophase of liquid crystals. This model could have significant consequences in the study, modeling and measurement of the operating parameters of future ma- chines and collectors of accelerators, in particular with regard to emission and brightness.