bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the validity of RMR equations in healthy Danish community-dwelling older adults
Authors: Schacht Simon , Fahrenholtz Ida Lysdahl , Melin Anna , Holm Lars , Tetens Inge 
Published: June 2020

AbstractBackgroundEstimating basal energy requirements is important in terms of assessing energy balance and targeting nutritional support. Assessing Resting Metabolic Rate (RMR) via indirect calorimetry is considered a reliable way of estimating basal energy requirements. Several RMR equations have been developed during the past century through indirect calorimetry, but only few have specifically focused on older adults (> 65 yrs). This may lessen the validity of the equations in relation to older adults, as body composition which is an important determinant for energy requirement changes considerably with age. Additional studies are therefore needed to assess the validity of available RMR equations in specific populations of older adults.AimThe aim of the present study was to investigate the validity of commonly available RMR equations in a group of older apparently healthy community-dwelling Danes (65 + y).MethodsRMR was measured by indirect calorimetry (mRMR) in 42 older individuals (10 females and 32 males; 65–81 years) participating in the CALM intervention study. Oxygen consumption and carbon dioxide production was measured for 25 min using a ventilated open hood system (Oxycon Pro 4; Jeager, Hoechberg, Germany). Predicted RMR (pRMR) was calculated using four different equations; the Harris-Benedict (1919) (HB), the Mifflin et al. (1990), the Lührmann et al. (2002) and the Henry et al. (2005) equations. The ratio between mRMR and pRMR (RMRratio) as well as the predictive ability (percentage of individual pRMR within + /-10% of mRMR) were calculated as a measure of validity.ResultsRMRratio for both sexes combined was 0.95 ± 0.08 for HB, 0.97 ± 0.07 for Mifflin et al., 0.92 ± 0.06 for Lürhmann et al. and 0.94 ± 0.07 for the Henry equations, respectively. The predictive ability was 73.8% (78.1% males and 60.0% of females, p = 0.410) for the HB, 81.0% (81.3% of males, and 80.0% of females, p≈1.00) for the Mifflin et al., 54.8% (56.3% of males and 50.0% of females, p≈1.00) for the Lührmann et al. equation, and 59.5% (59.4% of males and 60.0% of females, p≈1.00) for the Henry equations, respectively.ConclusionIn the present study, we found that the Mifflin equation was the most valid equations for predicting the RMR of older apparently healthy community-dwelling Danes. Generally, RMRratios and predictive ability were slightly lower for the H-B and Henry equations and lowest for the Lürhmann equation.
Available Starch: from food process control to lower glycemic response
Authors: Sophie Vinoy , Cesbron-Lavau Gautier , Meynier Alexandra , Goux Aurélie 
Published: June 2020

AbstractStarch is one of the major sources of carbohydrates (CHO) contributing to about 50–70% of the daily energy intake in human diet. Processed foods contribute to an important part of daily energy intake, especially in occidental countries. During food processing, starch undergoes dramatic changes when heated in the presence of water or high pressure. The objective of this work was to evaluate the impact of controlling food processes on starch digestibility profile in cereal-based foods and the interest of preserving starch in its native, slowly digestible, form on in vivo metabolic fate.Four different food processes were evaluated: extrusion, dry bread, soft cake and rotary-moulded biscuit. The resulting differences in gelatinization of each product translated to different SDS levels. Imaging techniques (X-ray diffraction, microtomography and electronic microscopy) were used to investigate the changes in SDS structure obtained through the different food processes. For in vivo evaluation, 12 healthy subjects were recruited and consumed a portion of 50 g of available CHOs of each product, in a crossover design. Glycemic and insulin responses were evaluated over 120 minutes in postprandial period.We showed that rotary molding technology preserved starch in its intact form and provided the highest SDS content (28g/100g) when the three other technologies (dried bread, soft cake and extrusion) led to SDS content below 3g/100 g. In addition, the lowest SDS contents are explained by a higher level of starch structure disruption which translated in a shift from crystalline structure into amorphous one. These data were linked to in vivo results. The global analysis for GI indicated that a significant difference existed among the foods’ mean GI values (p < 0.0001). Rotary product showed the lowest GI values. The soft, the dried bread had medium GI and extruded product had the highest GI with 77. The global analysis for II indicated that a significant difference existed among the foods’ mean II values (p < 0.0001), with the same order as for GI values. In addition, a portion of rotary-molded biscuit decreased significantly the glycemic peak by 1 mM compared to the 3 other products.Decrease of postprandial glycemia is a meaningful target in the prevention of metabolic diseases. This can be achieved through the modification of dietary factors such as starch digestibility.
Dietary assessment with the online platform MyFitnessPal: a reliable method?
Authors: Evenepoel Charlotte , Clevers Egbert , Deroover Lise , Matthys Christophe , Verbeke Kristin 
Published: June 2020

AbstractA major challenge in dietary assessment is the manual pre-processing of dietary data. Digital food registration via online platforms that are coupled to large food databases can automate this process. The accuracy of such platforms depends on the quality of the associated food database. In this study we validated the database of MyFitnessPal (MFP) versus the Belgian food composition database Nubel.Fifty participants collected a 4-day dietary record using MFP at 2 time points, T1 and T2. Nutrient intake values extracted from MFP at T1 were used as training set to define a cut-off for each parameter (energy intake (EI), carbohydrates (CH), fat (F), protein (P), fibre (Fi), sugar (S), cholesterol (Ch) and sodium (So)) by optimising correlation with Nubel calculated values. Application of these criteria to the values extracted at T2 (n = 2826) resulted in rejection rate of 2.8%. The remaining values were correlated (Pearson or Spearman) with the Nubel calculated values. Fixed and proportional biases were traced using Bland-Altman analysis and impact on sample size was estimated from a power simulation.MFP demonstrated strong correlation with the Nubel database for EI (r = 0.95), CH (r = 0.90), F (r = 0.90), P (r = 0.88), Fi (r = 0.80) and S (r = 0.77), but weak correlations for Ch (ρ = 0.51) and So (ρ = 0.53); all p < 0.001. Bland-Altman analysis showed no fixed bias between both methods, whereas a proportional bias was found for cholesterol. A practical implication is a loss of statistical power by 5–10% for EI and macronutrients compared to the Nubel database and the need to increase sample size accordingly.We conclude that dietary analysis with MFP is accurate and efficient for total energy intake, macronutrients, fibre and sugar, but not for cholesterol and sodium
Effect of folic acid supplementation during pregnancy on brain health of the child at 11 years: the FASSTT Offspring trial
Authors: Caffrey Aoife , Pentieva Kristina , McNulty Helene , Gaur Pramod , Talcott Joel B. , Witton Caroline , Cassidy Anthony , McLaughlin Marian , Lees-Murdock Diane J. , Irwin Rachelle E. , Walsh Colum P. , Prasad Girijesh 
Published: June 2020

AbstractPericonceptional folic acid (FA) has an established role in the prevention of neural tube defects (NTDs), leading to global recommendations for FA supplementation before and in early pregnancy. However, it is unclear whether there are any benefits for offspring brain health arising from continued maternal FA supplementation beyond the first trimester. The aim of this study was to investigate the role of maternal folate nutrition during pregnancy in relation to cognitive performance and brain function in the offspring at 11 years. The children of mothers who had participated in a randomised trial of Folic Acid Supplementation in the Second and Third Trimesters (FASSTT) were investigated, providing a unique opportunity to examine offspring brain health in relation to maternal folate (the FASSTT Offspring trial; n = 68). Cognitive performance was assessed using the Wechsler Intelligence Scale for Children, Fourth UK Edition (WISC-IV). The WISC-IV measures Full Scale IQ and specific domains of cognitive performance: Verbal Comprehension, Perceptual Reasoning, Working Memory and Processing Speed. Brain function was measured using magnetoencephalography (MEG) in a subset of the child participants (n = 33). The results showed no significant difference in Full Scale IQ between the children of mothers who had received folic acid versus placebo during pregnancy (P = 0.993). Processing Speed subtest scores were however significantly higher in the folic acid group compared with placebo (Symbol Search: P = 0.046 and Cancellation: P = 0.011). The application of MEG analysis showed that at rest, there were differences in brain functioning with significantly lower overall power at Broad band [1–48Hz] (P = 0.041) and a trend (not significant) towards lower power in all other frequency bands (Theta, Mu, Beta, Low Gamma and High Gamma) in children from the FA group compared with placebo. Results for the responses to the language task (congruent and incongruent sentences) in children from the FA group showed significantly lower power within the Theta band [4–8Hz] and significantly higher power within high frequency bands i.e. Beta [13–30 Hz] and High Gamma [49–70 Hz]. This suggested more efficient language processing abilities in these children compared to children of mothers in the placebo group. The findings provide scientific evidence that continuing FA supplementation beyond the periconceptional period that is protective against NTDs, may be beneficial for brain health in the offspring. Furthermore, this study demonstrates that MEG is a useful tool for objective assessment of functional brain activity in healthy children in response to nutrition intervention.
May Body Adiposity Index be used as adiposity diagnostic marker?
Authors: Hamulka Jadwiga , Górnicka Magdalena , Nasuta Urszula , Frackiewicz Joanna , Białkowska Agnieszka , Drywień Małgorzata , Ciecierska Anna , Zielinska Monika A. 
Published: June 2020

AbstractBody Adiposity Index (BAI) is the method of determining body fat content based on anthropometric measurements, proposed as an alternative to the BMI. Due to the fact that the hip circumference is taken into account in calculating BAI, it is suggested that this index better reflects the differences in women and men obesity than BMI. The aim of this study was to examine the association between BAI and other adiposity indices such as WHtR (Waist to Height Ratio), Body Mass Index (BMI), Waist Circumference (WC), sum of skinfolds, or adiposity tissue measured by bioelectrical impedance analysis (FM-BIA) among adults, independence of sex and age. The study group consisted of 336 adults (59% women, 41% men) aged 18–70 years, which was divided into two groups: 18–45 years (57%) and > 45 (43%) to further analysis. All anthropometric measurements: height (H), body weight (BW), WC, hip circumference (HC) skinfolds thickness were taken according to the standardized procedures, with light clothing and without shoes twice and averages were calculated. BIA was performed under standardized conditions according to the manufacturer's protocol (Maltron BioScan 920 ver.1.1). BAI was calculated as [HC (cm) / H (m)1.5 -18]. Linear regression was used to investigate the relationship between BAI and adiposity indices. BAI was positively associated with sex, age, BW, WC, FM-BIA, BMI, sum of 4 or 5 skinfolds and WHtR for all subjects, but the strongest with FM-BIA (β = 0.787, p < 0.001), BMI (β = 0.696, p < 0.001) or WHtR (β = 0.625, p < 0.00001) for total group. BAI correlation with BW, WC, FM-BIA, BMI or WHtR were stronger in women than in men, both for the total group and regards to age. The identified set of correlates explained (for above variables) 30–79%, of the total variation in BAI for women, and 15–49% for men. The stronger BAI correlation with sex was found in the older group (> 45 years old) than in younger (β = 0.582, p < 0.00001 vs. β = 0.372, p < 0.00001). In men aged > 45 years, stronger BAI correlations with the sum of 4 or 5 skinfolds were observed. The correlation between BAI and BW in men was weaker than in women regardless of age (β = 0.364, p < 0.00001 vs. β = 0.762, p < 0.00001). Considering strong correlation between BAI and fat content (FM-BIA), BMI, WHtR, WC and BW in women, it seems that BAI may be used to determine the content of adipose tissue or as a diagnostic marker, but in men its using need further research.
Plasma and Tissue Bioavailability and Blood Pressure Lowering Effects of Omega-3 Polyunsaturated Fatty Acids from Commonly Eaten, Naturally Enriched, Foods
Authors: Stanton Alice , Shortall Kathleen , El-Sayed Thora , Brennan Margaret , Buskandar Fahad , O'Donovan Fiona , James Kirstyn , Kennedy Jean , Hayes Heather , Owens Bronagh , Fahey Alan , Pender Niall , Moran Niamh , Williams David , Dolan Eamon 
Published: June 2020

AbstractGreater consumption of oily fish, and elevated plasma levels of the long-chain marine-derived omega-3 polyunsaturated fatty acids (PUFAs), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have been strongly and consistently associated with a reduced incidence of heart attacks, strokes, cognitive decline, Alzheimer's disease and cancers. Despite international guidelines recommending eating oily fish at least once per week (> 250mg/day DHA and EPA), many people do not eat fish, and only a small minority of the world's population have optimal omega-3-PUFA plasma and tissue levels. Hence, in this project, we studied the bioavailability and blood pressure lowering effects of recently developed alternatives to oily fish, namely chicken-meat and eggs naturally enriched with algae-sourced omega-3-PUFAs.This was a double-blinded, controlled, randomised trial. Using a 2X2 factorial design, 161 healthy participants were randomized to eat at least 3 portions/week of omega-3-PUFA enriched (or control) chicken-meat, and to eat at least 3 omega-3-PUFA enriched (or control) eggs/week, for 6 months.Compared to control foods, eating enriched eggs, enriched chicken-meat and the combination for 6 months, resulted in plasma EPA increments (μg/g) of 3.1[2.8], 8.8[2.9]* & 4.7[2.9], plasma DHA increments (μg/g) of 5.1[3.7], 9.3[3.8]* & 13.1[3.9]*, and omega-3-index (sum of EPA + DHA as a percentage of total fatty acids in erythrocytes, %) increments of 0.9[0.3]*, 0.7[0.4]* & 1.5[0.4]*, respectively. Mean 24-hour ambulatory blood pressure (systolic/diastolic, mmHg) declined with the enriched foods 0.3[1.3]/-0.2[1.0], -0.7[1.4]/-1.4[1.0], & -1.9[1.4]/-2.9[1.0]*, respectively. Data provided as mean difference[SEM], and * denotes p < 0.05.Regular consumption of omega-3-PUFA enriched chicken-meat and eggs resulted in statistically significant and clinically relevant increases in plasma and red cell levels of DHA and EPA. Both plasma and red cell bioavailability were similar to those previously described for oily fish. Furthermore, blood pressure, an important biomarker of cardiovascular health, decreased in those eating the omega-3-PUFA enriched foods. Omega-3-PUFA enriched chicken-meat and eggs offers consumers an attractive additional alternative to eating oily fish. Unlike many lifestyle interventions, long-term large population health benefits are not dependent on willingness of people to make long-lasting dietary changes, but on the widespread availability of a range of inexpensive, commonly eaten, naturally enriched foods.
Efficacy of different prediabetes program models in improving clinical outcomes in people with prediabetes
Authors: Al-Hamdan Rasha , McCullough Fiona , Avery Amanda , Al-Disi Dara , Al-Daghri Nasser 
Published: June 2020

AbstractBackground:Educational programs in general seem to have a clinically significant beneficial effect among the T2DM population in terms of improved glycaemic control. However, few evaluations of interventions to delay or prevent type 2 diabetes mellitus (T2DM) in Saudi Arabia (SA) have been undertaken.Objective:The present study evaluates for the first time, the differences in the effectiveness of the different educational programs [intensive lifestyle modification (Group Education Program, GEP), supervised education through social media (WhatsApp Education Group, WEP) and standard care via PHCCs (Control Group, CG)], among Saudi females with pre-diabetes.Methods:This was a 6-month, multi-center, 3-arm cluster, randomised, controlled (1:1:1), multi-intervention study conducted from July 2018 until March of 2019 in Riyadh, SA. A total of 1140 females from SA were cluster randomised equally to three groups, out of which only 253 [N = 100 GEP, N = 84 WEP and N = 69 CG] received intervention. Participants completed questionnaires including demographic, dietary and physical activity data. Anthropometrics, blood samples and dietary intake were collected at baseline and 6 months. A total of 120 [37 CG (age 50.9 ± 7.1 years; body mass index (BMI) 31.6 ± 5.8kg/m2), 40 GEP (age 42.9 ± 12.2 years; BMI 34.8 ± 9.0kg/m2) and 43 WEP (age 43.7 ± 8.1 years; BMI 30 ± 5.1kg/m2)] participants completed the study.Results:Haemoglobin A1c (HbA1c; primary endpoint) significantly improved in all groups over time, with no difference in between-group comparisons. Between group comparisons adjusted for age revealed a clinically significant reduction in BMI in favour of GEP (p = 0.02) post-intervention. A clinically significant reduction was also observed in favour of GEP in terms of weight (p = 0.003), waist circumference (p = 0.017), systolic and diastolic blood pressure (p-values < 0.01), triglycerides (p < 0.001) and caloric intake (p < 0.005) over time.Conclusion:Prediabetes education programs of 6-month duration, whether delivered through an intensive lifestyle modification, social media or standard care, are equally efficacious in improving HbA1c levels among Saudi women with prediabetes, but intensive lifestyle is superior in terms of weight reduction and over-all cardiometabolic improvement.
Ultra-processed food intake and risk of type 2 diabetes in a French cohort of middle-aged adults
Authors: Srour Bernard , Fezeu Léopold K. , Kesse-Guyot Emmanuelle , Allès Benjamin , Méjean Caroline , Debras Charlotte , Druesne-Pecollo Nathalie , Chazelas Eloi , Deschasaux Mélanie , Hercberg Serge , Galan Pilar , Monteiro Carlos A. , Julia Chantal , Touvier Mathilde 
Published: June 2020

AbstractIntroduction:The consumption of ultra-processed foods has been increasing during the last decades, and has been previously associated with increased risks of mortality and several chronic diseases such as cancer, cardiovascular diseases, hypertension, and dyslipidemia. The objective of this study is to assess the prospective associations between consumption of ultra-processed foods and the risk of type 2 diabetes (T2D).Methods:Overall, 104707 participants aged at least 18 years (median age 41.5 years) from the French NutriNet-Santé cohort (2009–2019) were included. Dietary intakes were collected using repeated 24 hour dietary records (5.7/subject in average), designed to register participants' usual consumption for 3300 different food items. These were categorized according to their degree of processing by the NOVA classification. Associations between ultra-processed food intake and risk of type 2 diabetes were assessed using multivariable Cox proportional hazard models adjusted for known risk factors (sociodemographic, anthropometric, lifestyle, medical history and nutritional factors).Results:Ultra-processed sugary products, fruits and vegetables, and beverages were the highest contributors of the ultra-processed category (respectively 27.9, 18.5 and 15.6%). Ultra-processed food intake was associated with a higher risk of T2D (n = 821 incident cases; hazard ratio for an absolute increment of 10 in the percentage of ultra-processed foods in the diet = 1.15 (95% confidence interval 1.06 to 1.25); P = 0.0009, median follow-up: 6.0y, 582252 person-years). These results remained statistically significant after adjustment for other metabolic comorbidities, for several markers of the nutritional quality of the diet (red meat and sugary drinks consumption, intakes of saturated fatty acids, sodium, sugar, dietary fiber or Healthy/Western patterns derived by principal component analysis) and after a large range of sensitivity analyses.Conclusions:In this large observational prospective study, higher consumption of ultra-processed foods in the diet was associated with a higher risk of type 2 diabetes. These results need to be confirmed in other populations and settings, and causality remains to be established. Various dimensions of processing such as nutritional composition of the final product, food additives, contact materials, and neoformed contaminants might play a role in these associations and further studies are needed to better understand their relative contribution. Meanwhile, public health authorities in several countries recently started to recommend privileging unprocessed/minimally processed foods and limiting ultra-processed food consumption.Study Registration: Clinicaltrials.gov NCT03335644.