bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uncoupled rocking and shear base‐mechanisms for resilient reinforced concrete high‐rise buildings
Authors: Tong Fei , Christopoulos Constantin 
Published: May 2020

SummaryHigh‐rise buildings are an efficient solution to meet the housing challenges of global urbanization that is happening at an incredible pace. Code‐based seismic design philosophies are aimed at achieving collapse‐prevention under major earthquakes, implying extensive structural damage associated with important losses. A number of high‐performance systems have been investigated for enhancing the resilience of high‐rise buildings whose design is especially challenging due to higher‐mode effects even when a flexural mechanism is formed at the base of the structure. To this end, this paper proposes a new concept consisting of a three‐dimensional uncoupled rocking and shear mechanism system for high‐rise buildings where reinforced concrete (RC) core walls are used as the lateral‐force‐resisting system. The proposed system provides a dual‐mechanism at the base that independently limits both overturning moments (OTMs) and shear forces and thus more effectively mitigates higher‐mode effects. The characteristic mechanics of the proposed system are first studied through an idealized model. A physical embodiment is then designed, detailed, and validated through advanced models and extensive nonlinear dynamic analyses. A 42‐story RC core‐wall building that is located in Los Angeles and was studied as part of the PEER Tall Buildings Initiative is used as a reference structure in this study. Results confirmed that the proposed system eliminates damage at the base of the walls and minimizes the inelastic demands over the height of the building. In a general sense, the proposed concept provides a framework in which the intended dual mechanism can be implemented to a wider range of high‐rise structures.
On seamless and high‐bandwidth connectivity for cognitive multi‐unmanned aerial vehicle‐assisted networks
Authors: Ul Hasan Najam , Ejaz Waleed , Zghaibeh Manaf , Ejaz Naveed , Alzahrani Bander 
Published: May 2020

AbstractUnmanned aerial vehicles (UAVs) can be useful in many different scenarios including disaster management. UAVs can immediately reach the disaster area and collect data that can help relief and rescue activities. Nevertheless, these advantages can be further improved when multiple UAVs coordinate for data collection from different vantage points simultaneously. However, seamless, high‐bandwidth communication between UAVs is required for this coordination. Nonetheless, due to the scarcity of bandwidth, a UAV network operating on an unlicensed ISM band may not be feasible. In this article, we follow a conceptual approach in which UAVs can access the licensed spectrum opportunistically. However, it is highly likely that various UAVs may have different sets of approved channels available and are unable to coordinate. Therefore, UAVs are divided into clusters to establish coordination in this scenario based on the availability of a common channel between different UAVs. Clustering based on a single common channel may still not be practical, due to the sporadic availability of common channels that often causes reclustering. Therefore, we present a multi‐UAV clustering scheme in which clusters of UAVs are established with more common channels to prevent repeated reclustering by having one main channel and the rest as backup channels. However, this may reduce the size of the cluster which can be addressed by limiting the number of backup channels. In this article, we present two variants of the proposed scheme: Multi‐UAV clustering‐I and multi‐UAV clustering‐II. The multi‐UAV clustering‐I scheme attempts to cluster UAVs with as many common channels as possible, whereas the multi‐UAV clustering‐II scheme attempts to limit the number of common channels to two. In addition, we propose a method for choosing the main channel from the different channels, where these channels are rated on the basis of bandwidth capacity and the channel with the highest rank is selected as the main channel. The remaining and the rest of the channels are kept as a backup. Simulation results demonstrate smooth and high‐bandwidth communication among UAVs.
Tracking Fisheries Through Time: The American Fisheries Society as a Historical Lens
Authors: Whelan Gary E , Day Diana M , Casselman John M , Gephart Laura , Hall Carolyn J , Lichatowich James , Matylewich Michael , Miranda Leandro , Roulson Leanne , Shirey Patrick D , Mercado-Silva Norman , Waldman John , Winters Drue 
Published: May 2020

Abstract
The historical context of current environmental conditions offers vital guidance to North American fisheries professionals as they strive to develop effective management plans and policies. Through this retrospective we highlight the remarkable historic fisheries resources and reasons for establishing public fisheries agencies and the American Fisheries Society (AFS). Through a review of primary historical documents and literature for North America, this paper identifies factors contributing to the founding of AFS and public fish commissions; shows how selected resource issues evolved; and documents how and why selected fisheries and aquatic habitat policies changed in response to those issues. Overexploitation, landscape-scale habitat alterations, mining, and dams were the causative agents for emergence of fisheries agencies and AFS, and these factors remain relevant today. Beginning in the 1960s, after 100 years of policy inaction, North Americans grew tired of degraded waters and fisheries and forced policy changes that have directly and indirectly affected the fisheries we manage today. The historical events and resulting corrective legislation are taken for granted by those unaware that AFS has actively participated in developing policies to address these environmental harms. Further, AFS continues to play a vital role in identifying key issues, providing conduits for information to cope with impairments, and advocating for policies to conserve intact habitats and improve degraded systems. The struggles documented in this paper offer crucial lessons as we continue to be challenged by legacy resource issues and face emerging environmental stressors, such as climate change, as well as regression in long-standing environmental protection policies.
Developmental assessments during the first 5 years of life in infants fed breast milk, cow's milk formula, or soy formula
Authors: Bellando Jayne , McCorkle Ginger , Spray Beverly , Sims Clark R. , Badger Thomas M. , Casey Patrick H , Scott Holly , Beall Sarah R. , Sorensen Seth T. , Andres Aline 
Published: May 2020

AbstractObjectiveTo investigate the effects of infant feeding mode on childhood cognition and language as the differential effects of infant feeding on development remain understudied.MethodsBreastfed [BF, 174], cow's milk‐based formula‐fed [MF, 169], or soy protein‐based formula‐fed [SF, 161] children were longitudinally tested from age 3 to 60 months for neurodevelopment. Data were analyzed using mixed models while adjusting for multiple covariates. Sex differences were also assessed.ResultsStandard scores were within established norms for all groups. There were no differences in mental development to age 24 months, yet BF children had significantly higher motor development scores at age 3 months than SF children (99.1 versus. 97.2). BF children had significantly higher composite intelligence scores at 48 months than MF and SF children (113.4 versus. 109.6 and 108.4, respectively) and higher verbal intelligence scores than SF children at 48 (105.6 versus. 100.7) and 60 months (109.8 versus. 105.9). Greater total language scores at ages 36 and 48 months were found in BF children compared with children fed MF or SF (p < .001), with differences between sexes for auditory comprehension. Higher total language scores at age 60 months were found between BF and SF (105.0 versus. 100.1).ConclusionBreastfeeding was associated with small, statistically significant, differences between children ages 3 and 5 years in verbal intelligence, expressive communication, and auditory comprehension with the latter having potential sexual dimorphic effects. Yet, these differences remain small and may not be of clinical relevance. Overall, MF and SF did not significantly differ.
Energy Management of a Hybrid Tidal Turbine‐Hydrogen Micro‐Grid: Losses Minimization Strategy
Authors: Barakat M. , Tala‐Ighil B. , Chaoui H. , Gualous H. , Hissel D. 
Published: May 2020

AbstractThis paper presents the modeling and energy management system (EMS) of a hybrid marine‐hydrogen power generation system. The proposed system aims to convert the static nature of the tidal energy into an active system by using a hydrogen energy storage system. The system of the tidal energy converter (TEC) considers the fixed pitch direct drive technology while the hydrogen system consists of 1.0 MW (megawatt) proton exchange membrane electrolyzer. A MATLAB/Simulink based model has been developed for studying and evaluating the effectiveness of the proposed EMS. The developed model depends on scaling up a 50 W proton exchange membrane (PEM) electrolyzer model to 1 MW scale by adapting the model parameters for providing the same key performance indicators (KPIs). The EMS aims to convert all the TEC generated energy into hydrogen with considering the efficient and safe operation of the different system components. Thus, the loss minimization (efficiency maximization) of the tidal turbine generator is integrated as one of the EMS goals to evaluate its effect on hydrogen production. The generator of the TEC is controlled by two different strategies for estimating the surplus hydrogen that could be produced. The strategies are the maximum torque/ampere and the loss minimization.
Estrogen Signaling and Portopulmonary Hypertension: The Pulmonary Vascular Complications of Liver Disease Study (PVCLD2)
Authors: Al‐Naamani Nadine , Krowka Michael J. , Forde Kimberly A. , Krok Karen L. , Feng Rui , Heresi Gustavo A. , Dweik Raed A. , Bartolome Sonja , Bull Todd M. , Roberts Kari E. , Austin Eric D. , Hemnes Anna R. , Patel Mamta J. , Oh Jae K. , Lin Grace , Doyle Margaret F. , Denver Nina , Andrew Ruth , MacLean Margaret R. , Fallon Michael B. , Kawut Steven M. ,   , for the Pulmonary Vascular Complications of Liver Disease Study Group
Published: May 2020

Background and Aims
Portopulmonary hypertension (POPH) was previously associated with a single‐nucleotide polymorphism (SNP) rs7175922 in aromatase (cytochrome P450 family 19 subfamily A member 1 [CYP19A1]). We sought to determine whether genetic variants and metabolites in the estrogen signaling pathway are associated with POPH.

Approach and Results
We performed a multicenter case‐control study. POPH patients had mean pulmonary artery pressure >25 mm Hg, pulmonary vascular resistance >240 dyn‐sec/cm−5, and pulmonary artery wedge pressure ≤15 mm Hg without another cause of pulmonary hypertension. Controls had advanced liver disease, right ventricular (RV) systolic pressure <40 mm Hg, and normal RV function by echocardiography. We genotyped three SNPs in CYP19A1 and CYP1B1 using TaqMan and imputed SNPs in estrogen receptor 1 using genome‐wide markers. Estrogen metabolites were measured in blood and urine samples. There were 37 patients with POPH and 290 controls. Mean age was 57 years, and 36% were female. The risk allele A in rs7175922 (CYP19A1) was significantly associated with higher levels of estradiol (P = 0.02) and an increased risk of POPH (odds ratio [OR], 2.36; 95% confidence interval [CI], 1.12‐4.91; P = 0.02) whereas other SNPs were not. Lower urinary 2‐hydroxyestrogen/16‐α‐hydroxyestrone (OR per 1‐ln decrease = 2.04; 95% CI, 1.16‐3.57; P = 0.01), lower plasma levels of dehydroepiandrosterone‐sulfate (OR per 1‐ln decrease = 2.38; 95% CI, 1.56‐3.85; P < 0.001), and higher plasma levels of 16‐α‐hydroxyestradiol (OR per 1‐ln increase = 2.16; 95% CI, 1.61‐2.98; P < 0.001) were associated with POPH.

Conclusions
Genetic variation in aromatase and changes in estrogen metabolites were associated with POPH.
Identification of Conservation Priority Zones Using Spatially Explicit Valued Ecosystem Services: A Case from the Indian Sundarbans
Authors: Sannigrahi Srikanta , Pilla Francesco , Basu Bidroha , Basu Arunima Sarkar , Zhang Qi , Wang Ying , Joshi Pawan Kumar , Chakraborti Suman , Coscieme Luca , Keesstra Saskia , Roy PS , Sutton Paul C 
Published: May 2020

Abstract
Demarcation of conservation priority zones (CPZs) using spatially explicit models is the new challenge in ecosystem services (ESs) research. This study identifies the CPZs of the Indian Sundarbans by integrating 2 different approaches, that is, ESs and ecosystem health (EH). Five successive steps were followed to conduct the analysis: First, the ESs were estimated using biophysical and economic methods and a hybrid method (that combines biophysical and economic methods); second, the vigor–organization–resilience (VOR) model was used for estimating EH; third, the risk characterization value (RCV) of ESs was measured using the function of EH and ESs; fourth, Pearson correlation test was performed to analyze the interaction between ESs and EH components; and fifth, the CPZs were defined by considering 7 relevant components: ecosystem vigor, ecosystem organization, ecosystem resilience, RCV, EH, ESs, and the correlation between EH and ESs. Among the major ecoregions of the Sundarbans, the highest ESs value in economic terms is provided by the mangrove ecosystem (US$19 144.9 million per year). The highest conservation priority score was projected for the Gosaba block, which is dominated by dense mangrove forests. The estimated CPZs were found to be highly consistent with the existing biodiversity zonations. The outcome of this study could be a reference for environmentalists, land administrators, researchers, and decision makers to design relevant policies to protect the high values of the Sundarbans ecosystem. Integr Environ Assess Manag 2020;16:773–787. © 2020 SETAC
Bees and the Environmental Impact of the Rupture of the Fundão Dam
Authors: Vieira Kamilla Ingred Castelan , Werneck Hugo de Azevedo , Santos Júnior José Eustáquio dos , Flores Dienny Sthefani da Silva , Serrão José Eduardo , Campos Lucio Antônio de Oliveira , Resende Helder Canto 
Published: May 2020

Abstract
The environmental consequences associated with the Fundão tailings dam failure in Mariana, Minas Gerais, Brazil on 5 November 2015 are still being investigated. Bees are the main pollinators believed to be most affected by the accident because they occur throughout the area affected by the dam rupture and build their nests in the soil. In this study, we evaluated the richness of different bee species in areas affected and not affected by the accident and measured the concentration of different metals on the pollen basket, or corbicula, located on the hind legs of Apis mellifera. Diversity indices were similar and there was no statistical difference in the diversity of bees sampled when comparing the sites affected and not affected by the tailings mud, either before or after the dam rupture. It is possible that the similarity is due to nearby forests that may be serving as areas of refuge. The levels of Al, Cu, Cd, Hg, and Pb in A. mellifera suggest no change in the level of metals in pollen collected by the bees that can be attributed to the rupture of the dam. Integr Environ Assess Manag 2020;16:631–635. © 2020 SETAC
The role of CDK6 in cancer
Authors: Nebenfuehr Sofie , Kollmann Karoline , Sexl Veronika 
Published: May 2020

AbstractThe regulation and function of cyclin‐dependent kinase 6 (CDK6)‐ and cyclin‐dependent kinase 4 (CDK4)‐cyclin complexes are commonly altered with enhanced kinase activity found in hematopoietic malignancies, breast cancer and melanoma making CDK4 and CDK6 attractive targets for therapeutic interference. Although dual CDK4/6 inhibitors have revolutionized treatment of breast cancer patients and reveal promising results in several solid tumors and hematological malignancies, there is a need for novel compounds targeting the versatile kinase‐independent functions of CDK6 to improve cancer treatment. The following review summarizes the latest findings on CDK6 in cancer development and discusses novel therapeutic approaches to selectively inhibit CDK6s function as a transcriptional regulator.
Simulations Studies of Protein Kinases that are Molecular Targets in Cancer
Authors: Friedman Ran , Bjelic Sinisa 
Published: May 2020

AbstractProtein kinases are enzymes with partially overlapping specificities, many of which are important clinical targets. In this article, we give some background on protein kinases and discuss in more depth four such enzymes that have been studied in our labs using computer simulations. The combination of molecular dynamics simulations and enzyme or cell growth experiments was instrumental to explain why certain mutations lead (or do not lead) to resistance to targeted therapy aimed at these proteins. Stochastic network simulations were used to study protein‐protein interactions and suggest points for intervention against tumour growth.
Depolarization metric spaces for biological tissues classification
Authors: Van Eeckhout Albert , Garcia‐Caurel Enric , Ossikovski Razvigor , Lizana Angel , Rodríguez Carla , González‐Arnay Emilio , Campos Juan 
Published: May 2020

AbstractClassification of tissues is an important problem in biomedicine. An efficient tissue classification protocol allows, for instance, the guided‐recognition of structures through treated images or discriminating between healthy and unhealthy regions (e.g., early detection of cancer). In this framework, we study the potential of some polarimetric metrics, the so‐called depolarization spaces, for the classification of biological tissues. The analysis is performed using 120 biological ex vivo samples of three different tissues types. Based on these data collection, we provide for the first time a comparison between these depolarization spaces, as well as with most commonly used depolarization metrics, in terms of biological samples discrimination. The results illustrate the way to determine the set of depolarization metrics which optimizes tissue classification efficiencies. In that sense, the results show the interest of the method which is general, and which can be applied to study multiple types of biological samples, including of course human tissues. The latter can be useful for instance, to improve and to boost applications related to optical biopsy.
Integrated photoacoustic and hyperspectral dual‐modality microscopy for co‐imaging of melanoma and cutaneous squamous cell carcinoma in vivo
Authors: Liu Ning , Chen Zhongjiang , Xing Da 
Published: May 2020

AbstractSkin carcinoma such as melanoma (MM) and cutaneous squamous cell carcinoma (cSCC) are considered as the highest mortality and the most aggressive skin cancers in dermatology. In view that early diagnosis and treatment can greatly improve the survival rate and life quality of the patients, developing noninvasive and effective evaluation methods is of great significance for the detection and identification of early stage cutaneous cancers. In this article, we propose a hybrid photoacoustic and hyperspectral dual‐modality microscopy to evaluate and differentiate skin carcinoma by structural and multiphysiological parameters. The proposed system's imaging abilities are verified by mimic phantoms and normal mice experiments. Furthermore, in vivo characterization and evaluation results of MM and cSCC mice are obtained successfully, which prove this novel method could be used as a reliable and useful method for skin cancer detection in early stages.
Acute thrombotic thrombocytopenic purpura in Louisiana: Seasonal distribution and evaluation of an ADAMTS13 order screening protocol
Authors: Simenson Victoria , Burton Jeffrey , Del Toro Alejandra , Alquist Caroline Raasch 
Published: May 2020

AbstractBackgroundThrombotic thrombocytopenic purpura (TTP) is a life‐threatening disorder caused by inactivation of ADAMTS13. It is characterized by thrombocytopenia and microangiopathic hemolytic anemia. Previous studies have produced conflicting data regarding seasonal association of TTP diagnoses. This study evaluated the seasonal distribution of acute TTP in southern Louisiana. Additionally, this study timeline overlapped with the initiation of a new screening protocol for ADAMTS13 testing.Study Design and MethodsA retrospective analysis of patients receiving ADAMTS13 testing at Ochsner Medical Center from January 2010 to December 2017 was performed. TTP patient episodes were defined by ADAMTS13 activity <10%. Episodes were plotted according to season of presentation and a chi‐square analysis was performed. Data of identified TTP patients was analyzed to evaluate for confounding variables. ADAMTS13 order volumes and results before and after screening protocol implementation were compared.ResultsTwo hundred and fifty‐two ADAMTS13 tests were ordered on 245 unique patients. Twenty‐five patients had ADAMTS13 activity <10%. No significant differences in seasonal TTP case distribution were identified. Patients with confirmed TTP were younger and more likely to be Black or African American. A screening protocol did not decrease the number of annual ADAMTS13 test orders in our time frame, but was associated with a nonsignificant increase in the percentage of positive results.ConclusionNo significant seasonal distribution of TTP was identified in our population. This analysis provides previously unexamined regional information regarding this diagnosis. The number of tests ordered after the implementation of the screening protocol increased, corresponding with our facility's expanding reach.
The increase of osteopontin and β‐carboxy‐terminal cross‐linking telopeptide of type I collagen enhances the risk of hip fracture in the elderly
Authors: Lin Jian‐Chun , Liu Zhong‐Guo , Liu Rui‐Ren , Xie Liang‐Wen , Xie Huang‐Lin , Cai He‐Guo 
Published: May 2020

AbstractBackgroundHip fracture in the elderly is a health burden worldwide due to its high mortality rate. This study was conducted to determine the possible mechanisms of osteopontin (OPN) and β‐carboxy‐terminal cross‐linking telopeptide of type I collagen (β‐CTX) in hip fracture in the elderly.Materials and MethodsIn the study, we recruited 108 elderly patients with hip fracture diagnosed from May 2012 to May 2015 at the Third Hospital of Xiamen and 86 healthy individuals without a history of hip fracture were taken as controls. Serum levels of OPN and β‐CTX were then determined. The T and Z values for bone mineral density (BMD) were also measured. Moreover, logistic regression analysis was performed to assess the risk and protective factors for hip fracture in the elderly.ResultsSerum levels of both OPN and β‐CTX were increased in elderly patients with hip fracture. OPN was positively correlated with β‐CTX. In addition, the levels of OPN and β‐CTX shared a positive association with the age, and a negative association with the BMD, in terms of T and Z values of the hip. In addition, increased BMD and outdoor sports might be protective factors for hip fracture, and an increase in levels of OPN and β‐CTX might be associated with a higher risk of hip fracture in the elderly population.DiscussionCollectively, increased serum levels of OPN and β‐CTX might be correlated with a higher risk of a hip fracture and have predictive values in the occurrence of hip fracture in the elderly.