bluuebunny/crossref_metadata_2025_split huggingface dataset:
The stimulation protocol in poor responder IVF; a minimal or high-dose stimulation? – A meta-analysis
Authors: Jamaludin Ridzuan , Ahmad Mohd Faizal , Park Dae-Keun , Zain Murizah Mohd , Yoon Tae-Ki , Lee Woo-Sik , Koong Mi Kyoung , Lee Kyung-Ah 
Published: November 2019

Abstract

Background
To determine whether a minimal stimulation (MS) or high-dose stimulation (HDS) protocol is a better option for patients classified as poor ovarian responders (POR) in terms of reproductive and pregnancy outcomes.

Materials and methods
A database search for evaluation of the study outcome by using meta-analysis method was carried out. The primary outcome was the clinical pregnancy (CP) rate for each of two groups, namely, the MS and HDS groups. The secondary outcomes were the gonadotropin dose used, duration of stimulation, cancellation rate, number of oocytes retrieved, number of fertilized oocytes, number of embryos transferred and live birth rates.

Results
Across five databases, 4670 potential studies for further screening were selected. But ultimately only six studies, three RCTs and three retrospective or case control studies were selected that meet the Bologna criteria for POR. In all there were 624 cycles. Our meta-analysis indicated that the CP rates, cycle cancellation rates, durations of stimulation, numbers of oocytes fertilized and numbers of embryos transferred were not statistically significant. Clearly, the number of oocytes retrieved in the MS group was significantly lower than in the HDS group, while the HDS group consumed significantly higher doses of gonadotropins than the MS group. The live birth rates were significantly higher in the MS group than in the HDS group.

Conclusion
MS should be the first-line protocol for managing POR because the live birth rate is significantly higher, even with fewer oocytes retrieved.
Furnace heat prediction and control model and its application to large blast furnace
Authors: Li Zhuang-nian , Chu Man-sheng , Liu Zheng-gen , Ruan Gen-ji , Li Bao-feng 
Published: November 2019

Abstract
Blast furnace heat is the key to the blast furnace’s high efficiency and stable operation, and it is difficult to maintain a suitable temperature for large blast furnace operations. When designing the furnace heat prediction and control model, parameters with good reliability and measurability should be chosen to avoid using less accurate parameters and to ensure the accuracy and practicability of the model. This paper presents an effective model for large blast furnace temperature prediction and control. Using thermal equilibrium and the carbon-oxygen balance of the blast furnace’s high-temperature zone, the slag-iron heat index was calculated. Using the relation between the molten iron temperature and slag-iron heat index, the furnace heat parameter can be calculated while production conditions are changed,which can guide furnace heat control.
Back from the Future: Divine Supercomprehension and Middle Knowledge as Ground for Retroactive Ontology
Authors: Hollingsworth Andrew 
Published: November 2019

Summary
In this article, I attempt to solve a problem in Wolfhart Pannenberg’s eschatology, which is best understood as a retroactive ontology. Pannenberg argues that the future exerts a retroactive causal and determinative power over the present, though he also claims that said future does not yet concretely exist. The problem can be posed thus: How does a non-concrete future hold retroactive power over the concrete present? I argue that the doctrines of middle knowledge and supercomprehension formulated by the Spanish Jesuit theologian Luis de Molina, provide an adequate solution to this problem while still preserving both the retroactive power of the nonconcrete future as well as genuine human libertarian free choice.
A surprising mechanism lacking the Ni(0) state during the Ni(II)-catalyzed P–C cross-coupling reaction performed in the absence of a reducing agent – An experimental and a theoretical study
Authors: Henyecz Réka , Mucsi Zoltán , Keglevich György 
Published: November 2019

Abstract
The Hirao reaction, i.e. the P–C coupling between a bromoarene and a >P(O)H reagent performed in most cases in the presence of a Pd(0) complex incorporating a P-ligand may also be carried out applying a Ni(II) catalyst precursor with or without Zn or Mg as the reducing agent. The Ni catalysts may include P- or N-ligands. B3LYP/6-31G(d,p)//PCM(MeCN) quantum chemical calculations suggested that the mechanism of the NiX2 catalyzed (X=Cl or Br) P–C couplings performed in the absence of a reducing agent, and in the excess of the >P(O)H reagent serving as the P-ligand (via its tautomeric >POH form) is completely different from that of the Pd(OAc)2 promoted version, as no reduction of the Ni(II) occurs. In the two variations mentioned, the active catalyst is the dehydrobrominated species derived from primary complex [(HO)Y2P]2Ni(II)Br2, and the [(HO)Y2P]2Pd(0) complex itself, respectively. Both species undergo temporary oxidation (to “Ni(IV)” and “Pd(II)”, respectively) in the catalytic cycle. During the catalysis with “P2Ni(II)X2”, one of the P-ligands serves the >P(O)H function of the ArP(O)H <  product. The consequence of this difference is that in the Ni(II)-catalyzed case, somewhat less >P(O)H-species is needed than in the Pd(0)-promoted instance. Applying 10 % of the Pd(OAc)2 or NiX2 precursor, the optimum quantity of the P-reagent is 1.3 equivalent and, in the first approach, 1.1 equivalent, respectively. Preparative experiments justified the new mechanism explored. The ligation of Ni(II) was also investigated by theoretical calculations. It was proved that the bis-complexation is the most favorable energetically as compared to the mono-, tri- and tetra-ligation.
Inverse approach for concentrated winding surface permanent magnet synchronous machines noiseless design
Authors: Delfa Patricio La , Hecquet Michel , Gillon Frederic 
Published: November 2019

Abstract
The electromagnetic noise generated by the Maxwell radial pressure is a well-known consequence. In this paper, we present an analytical tool that allows air gap spatio-temporal pressures to be obtained from the radial flux density created by surface permanent magnet synchronous machines with concentrated winding (SPMSM). This tool based on winding function, a global air-gap permeance analytical model and total magnetomotive force product, determines the analytical air-gap spatio temporal and spectral radial pressure.We will see step-by-step their impacts in generating noise process. Also two predictive methods will be presented to determine the origin of the lows radial pressure orders noise sources. The interest lies in keeping results very quickly and appropriate in order to identify the low order electromagnetic noise origin. Then through an inverse approach using an iterative loop a new winding function is proposed in order to minimize radial force low order previously identified and chosen.
The Institutional Dimension of Class-based Educational Decision-making: Evidence from Regional Variation in Switzerland
Authors: Combet Benita 
Published: November 2019

AbstractThis article examines to what extent the specific institutional arrangement of an education system moderates the influence of social background on students’ track allocation, and whether this happens via primary or secondary effects of social origin. I tackle the problem of omitted-variable bias by analyzing subnational education systems in Switzerland, a country with a variety of cantonal school systems but otherwise homogeneous institutions. The results show a complex picture. First, even though the absolute transition probability to the highest track is higher in education systems with low stratification for students of higher social background, this does not translate into a relative advantage as in most cantons the odds of transitioning do not differ between high and low social background students. Second, in line with previous research, I observe that the secondary effect of social origin prevails in more stratified education systems. Third, it is not possible to conclude with certainty that specific features of the education system enable high social background parents to disproportionately influence their children’s transition probabilities because the results are not robust.
Zwischen affirmativer Teilnehmer- und kritischer Beobachterperspektive
Authors: Nassehi Armin , Saake Irmhild 
Published: November 2019

Zusammenfassung
Dieser Kommentar nimmt eine Studie von Stefan Hirschauer über die Entstehung von geschlechtlichen Asymmetrien in der Schwangerschaft zum Anlass, um über die soziologische Form der Thematisierung von Symmetrien und Asymmetrien nachzudenken. In der genannten Studie wird in analytischer Absicht der moderne Kampf um symmetrische Anteile in der Elternschaft eindrücklich dargestellt, zugleich verstrickt er sich aber selbst in diesen Kampf, indem er sich für eine Symmetrisierung der (Vor-)Elternschaft engagiert. Der Beitrag changiert also zwischen kritischer Beobachtungs- und affirmativer Teilnehmerperspektive. Er weiß also schon stets, welche Lösung die bessere sei. Über eine solche affirmative Teilnehmerperspektive möchte der Kommentar hinausführen, indem er auf die „Kulturbedeutung“ (Weber) von modernen Symmetriepostulaten hinweist und zu einer kritischen Beobachtung des Umgangs mit Differenzen (Luhmann, Foucault) auffordert.
Crystal structures of the tetrachloridoaluminates(III) of rubidium(I), silver(I), and lead(II)
Authors: Knies Maximilian , Lê Anh Mai , Keßler Ulrich , Ruck Michael 
Published: November 2019

Abstract
The reactions of the binary metal chlorides AgCl, RbCl and PbCl2 at T = 180°C in the ionic liquid [BMIm]Cl · 4AlCl3 (BMIm = 1-n-butyl-3-methylimidazolium) yielded air-sensitive, colorless, high-quality crystals of their tetrachloridoaluminate(III) salts. Thereby, the obstructions that hinder proper crystallization of these compounds from pristine AlCl3 melts were circumvented. X-ray diffraction on single-crystals revealed a monoclinic structure (space group P21/c) for Ag[AlCl4], which unexpectedly has a closer relation to Cu[AlCl4]2 than to Cu[AlCl4]. Rb[AlCl4] crystallizes in the baryte structure type (orthorhombic, Pnma), and Pb[AlCl4]2 is isotypic to α-Sr[GaCl4]2 (orthorhombic, Pbca).
TMEM16A expression in cholinergic neurons of the medial habenula mediates anxiety‐related behaviors
Authors: Cho Chang‐Hoon , Lee Sangjoon , Kim Ajung , Yarishkin Oleg , Ryoo Kanghyun , Lee Young‐Sun , Jung Hyun‐Gug , Yang Esther , Lee Da Yong , Lee Byeongjun , Kim Hyun , Oh Uhtaek , Im Heh‐In , Hwang Eun Mi , Park Jae‐Yong 
Published: November 2019

AbstractTMEM16A, a Ca2+‐activated Cl− channel, is known to modulate the excitability of various types of cells; however, its function in central neurons is largely unknown. Here, we show the specific expression of TMEM16A in the medial habenula (mHb) via RNAscope in situ hybridization, immunohistochemistry, and electrophysiology. When TMEM16A is ablated in the mHb cholinergic neurons (TMEM16A cKO mice), the slope of after‐hyperpolarization of spontaneous action potentials decreases and the firing frequency is reduced. Reduced mHb activity also decreases the activity of the interpeduncular nucleus (IPN). Moreover, TMEM16A cKO mice display anxiogenic behaviors and deficits in social interaction without despair‐like phenotypes or cognitive dysfunctions. Finally, chemogenetic inhibition of mHb cholinergic neurons using the DREADD (Designer Receptors Exclusively Activated by Designer Drugs) approach reveals similar behavioral phenotypes to those of TMEM16A cKO mice. We conclude that TMEM16A plays a key role in anxiety‐related behaviors regulated by mHb cholinergic neurons and could be a potential therapeutic target against anxiety‐related disorders.
Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB
Authors: Wang Yusha , Huang Yewei , Liu Jiaqi , Zhang Jinna , Xu Mingming , You Zhiyuan , Peng Chao , Gong Zhefeng , Liu Wei 
Published: November 2019

AbstractAccumulating evidence highlights the role of histone acetyltransferase GCN5 in the regulation of cell metabolism in metazoans. Here, we report that GCN5 is a negative regulator of autophagy, a lysosome‐dependent catabolic mechanism. In animal cells andDrosophila, GCN5 inhibits the biogenesis of autophagosomes and lysosomes by targeting TFEB, the master transcription factor for autophagy‐ and lysosome‐related gene expression. We show that GCN5 is a specific TFEB acetyltransferase, and acetylation by GCN5 results in the decrease in TFEB transcriptional activity. Induction of autophagy inactivates GCN5, accompanied by reduced TFEB acetylation and increased lysosome formation. We further demonstrate that acetylation at K274 and K279 disrupts the dimerization of TFEB and the binding of TFEB to its target gene promoters. In a Tau‐based neurodegenerativeDrosophilamodel, deletion of dGcn5 improves the clearance of Tau protein aggregates and ameliorates the neurodegenerative phenotypes. Together, our results reveal GCN5 as a novel conserved TFEB regulator, and the regulatory mechanisms may be involved in autophagy‐ and lysosome‐related physiological and pathological processes.
Diş Hekimliği Eğitiminde Beceri Kavramı: 21. Yüzyıl Becerileri
Authors: Akaltan Kadriye Funda 
Published: November 2019

Amaç:

Diş
hekimliğinde beceri kavramı; akla mesleki becerileri getirir. Oysa ki; mezun
diş hekimlerinin sadece klinik beceri kazanmakla kalmayıp, topluma iyi hizmet
sunabilmek için - iletişim, düşünme ve problem çözme, takım çalışması gücü,
hayat boyu öğrenme ve bilgi yönetimi, girişimcilik, etik, ahlak ve
profesyonellik ve liderlik gibi - 21.
yüzyıl becerilerine sahip olmaları da gerekir. Hekimlerin etkili uyum
becerisine sahip olması durumunda, hasta memnuniyetinin ve tedaviden sağlanan
faydanın arttığı; hasta anksiyetesinin ve hasta şikayetlerinin azaldığı
bilinmektedir. Diş hekimlerinin tedavi uygulamalarında güncel bilgi ve
becerileri yakalamaları, zor tedavi planlamalarını başedebilmeleri, çalışma
ortamlarındaki işbirlikçi çalışmaya uyum sağlamaları açısından da uyum
becerilerinin önemi büyüktür. Yetkin mezunların yetiştirilmesi için
fakültelerin müfredatlarında uyum becerisi eğitimine de yer vermeleri beklenir.
Anahtar kelimeler: diş hekimliği eğitimi, beceri eğitimi, 21. yüzyıl
becerileri.
Model of impact of household assets on labor price: European experience
Authors: Petkova Lesia , Zagoruiko Ivan , Palamarchuk Dmytro 
Published: November 2019

This article deals with existing models of household behavior, based on the assumption of the possibility of employees to determine their own level of consumption and employment, depending on a given wage rate and accumulated assets. An alternative view is offered that the wage rate accepted by employees can be expressed through financial assets and employment. Based on this assumption, the model "financial assets – labor price" was developed, determining the impact of the volume of financial assets of households and the level of employment on the wage rate, the minimum acceptable for workers.
The model was tested in twelve European countries. The calculations confirmed the basic hypothesis of the study, namely the dependence of the level of wages on the volume of available assets and employment.
Antioxidant, Antibacterial Activity and GC-MS Analysis of Extract of Giant Forest Ant Dinomyrmex gigas (Latreille, 1802)
Authors: Evana Evana - , Pratiwi Pratiwi , Fathoni Ahmad , Efendi Oscar , Agusta Andria 
Published: November 2019

Giant forest ant Dinomyrmex gigas is one of the largest ants species in the world, native to the rain forests of Southeast Asia. It is known that ants have glands that produce chemical compounds that inhibit the growth of microbes. Therefore, it is necessary to deter-mine the antioxidant and antibacterial activities as well as identify the chemical compounds of D. gigas extract. D. gigas was extracted successively with n-hexane, ethanol and methanol. The antioxidant activity was evaluated by determination of the half-maximal inhibi-tory concentration (IC50) values while the antibacterial activities of the extracts were determined by measuring the minimum inhibitory concentration (MIC). The results exhibited that the IC50 values of n-hexane, ethanolic and methanolic extracts were 336.18±0.0984, 89.16±0.0219 and 90.72±0.0894 μg/mL respectively. The ethanolic extract exhibited the highest AAI value (0.34) followed by metha-nolic extract (0.33) and n-hexane extract (0.09). Based on AAI val-ues, the extracts were classified as moderate antioxidants. The best MIC values were 625 μg/mL for both ethanolic and methanolic ex-tracts against S. aureus, while MIC values of all extracts against E. coli were >625 μg/mL. Based on MIC values, all of the extracts presented weak activity against both S. aureus and E.coli. The GC-MS analysis showed that there are up to 30 compounds construct-ed of the ethanolic extract. Three major compounds are ethyl oleate (29.78%), n-hexadecanoic acid (17.54%) and oleic acid (10.65%).
Intratumoral Immunotherapy—Update 2019
Authors: Hamid Omid , Ismail Rubina , Puzanov Igor 
Published: November 2019

Abstract

Intratumoral immunotherapies aim to trigger local and systemic immunologic responses via direct injection of immunostimulatory agents with the goal of tumor cell lysis, followed by release of tumor-derived antigens and subsequent activation of tumor-specific effector T cells. In 2019, a multitude of intratumoral immunotherapies with varied mechanisms of action, including nononcolytic viral therapies such as PV-10 and toll-like receptor 9 agonists and oncolytic viral therapies such as CAVATAK, Pexa-Vec, and HF10, have been extensively evaluated in clinical trials and demonstrated promising antitumor activity with tolerable toxicities in melanoma and other solid tumor types. Talimogene laherparepvec (T-VEC), a genetically modified herpes simplex virus type 1–based oncolytic immunotherapy, is the first oncolytic virus approved by the U.S. Food and Drug Administration for the treatment of unresectable melanoma recurrent after initial surgery. In patients with unresectable metastatic melanoma, T-VEC demonstrated a superior durable response rate (continuous complete response or partial response lasting ≥6 months) over subcutaneous GM-CSF (16.3% vs. 2.1%; p &lt; .001). Responses were seen in both injected and uninjected lesions including visceral lesions, suggesting a systemic antitumor response. When combined with immune checkpoint inhibitors, T-VEC significantly improved response rates compared with single agent; similar results were seen with combinations of checkpoint inhibitors and other intratumoral therapies such as CAVATAK, HF10, and TLR9 agonists. In this review, we highlight recent results from clinical trials of key intratumoral immunotherapies that are being evaluated in the clinic, with a focus on T-VEC in the treatment of advanced melanoma as a model for future solid tumor indications.
The Impact of Nonsteroidal Anti-Inflammatory Drugs, Beta Blockers, and Metformin on the Efficacy of Anti-PD-1 Therapy in Advanced Melanoma
Authors: Wang Daniel Y. , McQuade Jennifer L. , Rai Rajat R. , Park John J. , Zhao Shilin , Ye Fei , Beckermann Kathryn E. , Rubinstein Samuel M. , Johnpulle Romany , Long Georgina V. , Carlino Matteo S. , Menzies Alexander M. , Davies Michael A. , Johnson Douglas B. 
Published: November 2019

Abstract
Anti–programmed cell death protein-1 (anti-PD-1) therapy has greatly improved outcomes of patients with melanoma; however, many fail to respond. Although preclinical studies suggest a potentially synergistic relationship with anti-PD-1 therapy and certain concurrent medications, their clinical role remains unclear. Here, we retrospectively evaluated the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and other drugs in 330 patients with melanoma treated with anti-PD-1 therapy from four academic centers. In the cohort, 37% of patients used NSAIDs including aspirin (acetylsalicylic acid; ASA; 47%), cyclooxygenase (COX)-2 inhibitors (2%), and non-ASA/nonselective COX inhibitor NSAIDs (59%). The objective response rates (ORRs) were similar in patients with NSAID (43.4%) and no NSAID (41.3%) use with no significant difference in overall suvival (OS). There was a trend toward improved progression-free survival (PFS) in patients who took NSAIDs (median PFS: 8.5 vs. 5.2 months; p = .054). Most patients (71.3%) took NSAIDs once daily or as needed. Multivariate analysis did not reveal an association with NSAID use with ORR, PFS, or OS. Concurrent use of metformin or beta blockers did not affect ORR, PFS, or OS. Our study found no conclusive association of concurrent NSAID or other medication use with improved outcomes in patients with melanoma treated with anti-PD-1 therapy. Larger and more systematic analysis is required to confirm these findings.
EROZİV ORAL LİKEN PLANUS’TA ENJEKTE EDİLEBİLEN TROMBOSİTTEN ZENGİN FİBRİN: ÇİFT KÖR, BÖLÜNMÜŞ AĞIZ, RANDOMİZE KONTROLLÜ PİLOT ÇALIŞMA
Authors: SAĞLAM Ebru , ÖZSAĞIR Zeliha Betül , ÜNVER Tuğba , TOPRAK Ali , BAYER ALINCA Suzan , TUNALI Mustafa 
Published: November 2019

Amaç: Bu
çalışmanın amacı, enjekte edilebilen trombositten zengin fibrin'nin (i-PRF) eroziv liken planus (EOLP) lezyonları
üzerindeki klinik etkisini değerlendirmek ve kortikosteroid tedavisi ile
karşılaştırmaktır.

Gereç ve Yöntem: Yanak
mukozasında çift taraflı EOLP bulunan 13 sistemik sağlıklı hastanın yanak
mukozalarının bir tarafına i-PRF, diğer tarafına intralezyonel kortikosteroid enjeksiyonu
yapılmıştır. Enjeksiyonlar 15 gün araya 4 seans tekrarlanmıştır. Sübjektif
değerlendirme belirteci olarak görsel analog skala (VAS), objektif
değerlendirme belirteci olarak Thongprasom skorları kullanılmıştır. Skorlamalar
tedaviden önce, son enjeksiyon seansından hemen sonra, tedavi sonrası 1. ay ve
tedavi sonrası 2. ay kontrol seanslarında yapılmıştır.

Bulgular: Gruplar
arası karşılaştırmada, başlangıç ve kontrol seanslarında VAS-Ağrı ,
VAS-Memnuniyet ve Thongprasom skorlarında istatistiksel olarak anlamlı bir fark
bulunamamıştır. Grup içi karşılaştırmalarda hem i-PRF uygulanan grupta (VAS-Ağrı
83,46 ± 16,25'ten 7,69 ± 9,92'ye düştü (p &lt;0,001), VAS-Memnuniyet 26,54 ±
19,73'ten 87,31 ± 9,71'e yükseldi (p &lt;0,001), Thongprasom skorları 4,85 ±
0,37'den 2,08 ± 1,04'e düştü (p = 0,001)), hem de kortikosteroid uygulanan
grupta (VAS-Ağrı 83,46 ± 16,25'ten 10,77 ± 14,27'ye düştü (p &lt;0,001), VAS-Memnuniyet
26,54 ± 19,72'den 84,23 ± 13,52'ye yükseldi (p &lt;0,001), Thongprasom skorları
4,54 ± 0,52'den 2,00 ± 1,22’e düştü (p = 0,001)) VAS-Ağrı ve Thongprasom skorlarının ortalama
değerlerinde istatistiksel olarak anlamlı bir düşüş görülürken, VAS-Memnuniyet
skorlarının ortalamasında istatistiksel
olarak anlamlı bir artış gözlenmiştir. Sonuç: Bu pilot çalışma, i-PRF enjeksiyonunun EOLP lezyonların tedavisinde
altın standart kabul edilen kortikosteroid enjeksiyonuna benzer derecede etkili
olabileceğini göstermiştir.
Rapprochement Urbanism
Authors: Pierce West Kendon , Gregory Alexis 
Published: November 2019

Rapprochement urbanism addresses how wild environments can be accommodated in urban spaces to create more sustainable and resilient cities. Referring to the dual realities of wilderness and urbanity, this design strategy explores the interaction of their two structures to replace the misconception that cities are built “on” the natural environment, with the assertion that cities are built “in” it. Jackson, Mississippi currently treats adjacent vibrant ecological habitats as forgotten back alleys rather than urban assets. Utilizing interventions within a holistic plan, rapprochement urbanism combats urban sprawl and “back alley” attitudes, mitigates stormwater challenges, and facilitates human and animal spatial needs. Rapprochement urbanism, through the rewilding of Jackson, MS, allows architects to more directly impact and improve the ecological sustainability of this city of 170,000 inhabitants.[i]

i“Jackson, Mississippi.” Jackson, Mississippi (MS) Profile: Population, Maps, Real Estate, Averages, Homes, Statistics, Relocation, Travel, Jobs,Hospitals, Schools, Crime, Moving, Houses, News, Sex Offenders. http://www.city-data.com/city/Jackson -Mississippi.html (Accessed November 01, 2018).