bluuebunny/crossref_metadata_2025_split huggingface dataset:
MONET: Multi-omic patient module detection by omic selection
Authors: Rappoport Nimrod , Safra Roy , Shamir Ron 
Published: February 2020

AbstractRecent advances in experimental biology allow creation of datasets where several genome-wide data types (called omics) are measured per sample. Integrative analysis of multi-omic datasets in general, and clustering of samples in such datasets specifically, can improve our understanding of biological processes and discover different disease subtypes. In this work we present Monet (Multi Omic clustering by Non-Exhaustive Types), which presents a unique approach to multi-omic clustering. Monet discovers modules of similar samples, such that each module is allowed to have a clustering structure for only a subset of the omics. This approach differs from most extant multi-omic clustering algorithms, which assume a common structure across all omics, and from several recent algorithms that model distinct cluster structures using Bayesian statistics. We tested Monet extensively on simulated data, on an image dataset, and on ten multi-omic cancer datasets from TCGA. Our analysis shows that Monet compares favorably with other multi-omic clustering methods. We demonstrate Monet’s biological and clinical relevance by analyzing its results for Ovarian Serous Cystadenocarcinoma. We also show that Monet is robust to missing data, can cluster genes in multi-omic dataset, and reveal modules of cell types in single-cell multi-omic data. Our work shows that Monet is a valuable tool that can provide complementary results to those provided by extant algorithms for multi-omic analysis.
Molecular basis for regulation of human potassium chloride cotransporters
Authors: Chi Ximin , Li Xiaorong , Chen Yun , Zhang Yuanyuan , Su Qiang , Zhou Qiang 
Published: February 2020

AbstractThe Solute Carrier Family 12 (SLC12) encodes electroneutral cation-chloride cotransporters (CCCs) that are fundamental in cell volume regulation and chloride homeostasis. Dysfunction of CCCs engenders abnormality in renal function and neuro-system development. Here we presented structure of the full length human potassium-chloride co-transporter 2 (KCC2) and 3 (KCC3), the KCC3 mutants in phosphorylation mimic (P-mimic) and dephosphorylation mimic (DP-mimic) status, and KCC3 in complex with [(DihydroIndenyl)Oxy] Alkanoic acid (DIOA), a specific inhibitor of KCCs, at resolution of 2.7 Å - 3.6 Å. A small N-terminal loop is bound at the intracellular vestibule of the transport path, arresting the transporter in an auto-inhibition state. The C-terminal domain (CTD) of KCCs is structure-solved for the first time, revealing two conserved phosphorylation harboring segments (PHSs), which exhibit different conformation between P-mimic and DP-mimic mutants, explaining the inhibitory effect of phosphorylation. DIOA is located in between the two transmembrane domains, tightly bound to the loop between TM10 and TM11, locking the transporter in inward-facing conformation. Together, our study makes important steps in understanding the sophisticated regulation mechanisms of KCCs, with prospect for the specific drug development.
Standardizing the free and independent professional
Authors: Löwstedt Martin , Sandberg Rikard 
Published: February 2020

PurposeResearch concerned with standardization of the construction process has generally considered the challenges from only rational and instrumental perspectives. The purpose of this paper is to foreground a social perspective of this challenge. Specifically, the work of construction site managers is explored through a professional work lens in order to emphasize significant misalignments with the principles of standardized production in the construction industry.Design/methodology/approachData are drawn from a longitudinal (2014–ongoing) case study of site managers’ work in a large Swedish construction company. The research design is characterized by an explorative approach, altogether consisting of 44 in-depth interviews at the site manager level (28) and at other managerial levels (16). All the interviews were transcribed verbatim and analyzed particularly to highlight two contrasting dominant discourses: “standardized construction production” and “site manager work.”FindingsThe findings show that site manager’s work is enmeshed with a particular type of professional expertise and identity that is ideologically crafted around a proclivity for free and independent work. It is outlined in detail how these social dimensions of work are enacted to form an ongoing (and successful) resistance to organizational initiatives that are based on principles of standardization.Originality/valueThis study improves our understanding of an unresolved social challenge that impedes the transformation toward more standardized construction production. It adds new perspectives and value to current research by reminding that (and how) significant changes in production processes also seriously implicate professional work.
Omnichannel strategy and customer loyalty in banking
Authors: Mainardes Emerson Wagner , Rosa Carlos Anderson de Moura , Nossa Silvania Neris 
Published: February 2020

PurposeSupported by the omnichannel strategy, the objective of this study is to identify the influence of integrated interaction quality and perceived fluency of service channels on attitudinal loyalty in the banking sector and to test the mediating effect of positive affect in these relationships.Design/methodology/approachThis paper proposes a model that relates the constructs of integrated interaction quality, perceived fluency, positive affect, and attitudinal loyalty. A survey of 337 Brazilian bank clients was conducted and structural equation modeling was used for data analysis.FindingsThe results indicate that the construct of integrated interaction quality exerts positive influence on the loyalty of bank clients. The direct effect of the construct perceived fluency on loyalty is not significant. The results also demonstrate that positive affect exerts a mediating effect on the proposed relationships between the constructs.Research limitations/implicationsThis research assists banks in identifying relevant points regarding their service channels, so that they can determine how to generate positive experiences and customer loyalty through an omnichannel strategy. One can observe the behavior of banking consumers and develop business strategies based on the service channels, which aim to create a more profitable and loyal customer portfolio.Originality/valueThis study expands the literature regarding the omnichannel strategy by extending focus to include bank marketing, which is infrequently included in the body of such literature. This study also expands bank marketing research by including constructs that deal with consumer experience and loyalty.
Cruising back to the basic needs
Authors: Severt Denver E. , Tasci Asli D.A. 
Published: February 2020

PurposeTourism activities inherently include the liminoid state of mind that impels people to go out of ordinary behavior, some of which is inversionary. The purpose of this paper is to explore travelers’ cruise behavior as related to their needs while entering and experiencing a cruise trip.Design/methodology/approachA total of 395 vacationers were sampled and surveyed about their selected top three factors for cruising, motivations for cruising and needs while cruising. The sample was grouped into inversioners and rejuvenators to see if there was any evidence of liminoid behavior in cruising needs and what they may be.FindingsThe results show that the important reasons to choose cruises for vacation are aligned with past literature showing that people choose cruises for vacation mostly for the good value of the food and beverage bundled with good climate, entertainment appropriate for quality time with family and for rest and relaxation. In addition, the results on motivations to go on a cruise show that lower-level needs on Maslow’s hierarchy of needs have more importance than the higher-level needs.Research limitations/implicationsThe current study was conducted on an online platform. Future research with panels of cruise travelers across all the stages of liminoid behavior, before, during and after a cruise trip, may provide valuable findings in terms of changes in needs and motivations.Practical implicationsThe inversionary tendency of cruise travelers implies for the cruise industry the need to create an alternative (or inversionary) routine restoring the basic needs, while still providing enough opportunities for self-actualization that may foster balanced travel experiences for human growth and development. Providing a more balanced product and service offering may be strategic for the cruise companies because the activities geared for higher-level needs may provide memorable experiences and hence induce consumer loyalty after the trip is completed.Social implicationsThe focus on eating and drinking during cruises may be providing cruise travelers with instant gratification during the span of the cruise. However, the consequences for the individual travelers, the industry, destinations and the environment may not be as gratifying. For a more responsible tourism, cruise travel may need an image makeover highlighting different packages within a cruise to better align with the desired needs of different segments of cruisers.Originality/valueThe study contributes to the understanding of the second or “transition” stage in liminal theory in tourism and is one of the first to examine the liminoid state of mind using a basic-needs approach for studying cruise traveler needs. Further, it contributes by exploring liminoid behavior of a group of people in the context of the same type of travel, cruise, rather than investigating liminoid behavior across different types of travel, thus allowing segmentation possibilities for the cruise industry.
A new measure of private rental market regulation index and its effects on housing rents
Authors: Weber Jan Philip , Lee Gabriel 
Published: February 2020

Purpose
The purpose of this paper is twofold: first, the authors construct a country-specific time-varying private rental regulation index for 18 developed economies starting from 1973 to 2014. Second, the authors analyze the effects of their index on the housing rental markets across 18 countries and states.

Design/methodology/approach
The authors’ index not only covers 18 developed economies over 42 years but also combines both tenure security and rent laws. The authors’ empirical framework is that of panel regressions with time and country fixed effects.

Findings
The authors’ index sheds further insights on the extent to which rent and tenure security laws have converged over the past 40 years for each economy. Moreover, the authors show three empirical results. First, stringent rent control regimes do lead to lower real rent growth rates than regimes with free rents. Second, soft rent control regimes with time-limited tenure security and minimum duration periods, however, may cause higher rent growth rates than free rent regimes. Third, rent-free regimes do not show significant high real rent appreciation rates.

Originality/value
The authors’ rental regulation index is the first time-varying index that covers more than 18 economies over 40 years.
Do green HRM practices influence employees' environmental performance?
Authors: Hameed Zahid , Khan Ikram Ullah , Islam Tahir , Sheikh Zaryab , Naeem Rana Muhammad 
Published: February 2020

PurposeRecent research has demonstrated an increasing awareness among business communities about the importance of environmental concerns. Green human resource management (GHRM) has become a crucial business strategy for organizations because the human resource department can play a key role in going “green.” This study tests an integrative model incorporating the indirect effects of GHRM practices on employee organizational citizenship behavior toward environment (OCBE), through green employee empowerment. Moreover, this study investigates the moderating effect of individual green values on OCBE.Design/methodology/approachUsing a paper–pencil survey, we collected multisource data from 365 employees and their immediate supervisors from Pakistan.FindingsThe results of structural regression revealed that GHRM has a significant indirect effect on OCBE through green employee empowerment. The results also indicated that individual green values moderated the positive relationship between green employee empowerment and OCBE.Practical implicationsOrganizations should appropriately appraise workers’ green behavior and align their behavior to pay and promotion. Organizations should also encourage and motivate employees to be engaged in green activities and contribute to environmental management.Originality/valueThis study suggests that green employee empowerment and individual green values are important factors that influence the relationship between GHRM and employees' OCBE, and it empirically analyzes these proposed relationships in a developing country context.
Young luxury fashion consumers' preferences in multi-channel environment
Authors: Lee Hanna , Rothenberg Lori , Xu Yingjiao 
Published: February 2020

PurposeThe purpose of this paper is to explore and examine the relative impact of product and channel attributes on luxury product shopping in the multi-channel environment.Design/methodology/approachA D-optimal discrete choice conjoint design was used. The data were analysed using a multinomial logit model and desirability indices.FindingsFindings indicate that low price was the most important factor that influenced young consumers' preferences. After price, young luxury consumers placed a greater importance on channel attributes such as human-assisted service and virtual fitting rooms.Research limitations/implicationsThe sample consisted of young consumers in their 20s and 30s, who utilise both online and offline channels. Hence, the income level was relatively low. Also, the results cannot be generalised to all luxury consumers.Practical implicationsProviding preferable channel attributes is more crucial to young luxury fashion shoppers than focusing on improving product attributes, with the exception of price.Originality/valueThe paper proposes the optimal combination of key product and channel attributes that is most preferable to young luxury fashion consumers in the multi-channel environment.
The effect of using videos in teaching and learning English present progressive tense
Authors: Qadha Adil Mohammed Hamoud , Alward Mohammed Ahmed 
Published: February 2020

PurposeUsing videos in language learning has been investigated in the literature to enhance second language learning. The previous studies have explored the effect of videos on learning a foreign language, especially vocabulary learning. The purpose of this study is to investigate the effect of videos on learning present progressive tense in the perspective of semiotics.Design/methodology/approachA total of 30 Arab English foreign language (EFL) learners participated in the study and were assigned into two groups. The first group was taught present progressive tense with the help of videos (the semiotics group). The second group was taught the same content using a traditional way, i.e. without videos.FindingsResults of the post-test indicated that participants in the semiotics group outscored the participants who did not learn through videos to learn present progressive tense. The study concluded that using videos is a useful tool to enhance learning present progressive tense.Originality/valueTo the authors’ knowledge, no study has been conducted to examine the effect of semiotics on learning L2 grammar, especially the present progressive tense. Therefore, this study explores the impact of using videos, as a form of semiotics, to help EFL learners learn present progressive tense.
Development of sustainable construction material from fly ash class C
Authors: Asa Eric , Shrestha Monisha , Baffoe-Twum Edmund , Awuku Bright 
Published: February 2020

Purpose
Environmental issues caused by the production of Portland cement have led to it being replaced by waste materials such as fly ash, which is more economical and safer for the environment. Also, fly ash is a material with sustainable properties. Therefore, this paper aims to focus on the development of sustainable construction materials using 100% high-calcium fly ash and potassium hydroxide (KOH)-based alkaline solution and study the engineering properties of the resulting fly ash-based geopolymer concrete. Laboratory tests were conducted to determine the mechanical properties of the geopolymer concrete such as compressive strength, flexural strength, curing time and slump. In phase I of the study, carbon nanotubes (CNTs) were added to determine their effect on the strength of the geopolymer mortar. The results derived from the experiments indicate that mortar and concrete made with 100% fly ash C require an alkaline solution to produce similar (comparable) strength characteristics as Portland cement concrete. However, it was determined that increasing the amount of KOH generates a considerable amount of heat causing the concrete to cure too quickly; therefore, it is notable to forming a proper bond was unable to form a stronger bond. This study also determined that the addition of CNTs to the mix makes the geopolymer concrete tougher than the traditional concrete without CNT.

Design/methodology/approach
Tests were conducted to determine properties of the geopolymer concrete such as compressive strength, flexural strength, curing time and slump. In Phase I of the study, CNTs were studied to determine their effect on the strength of the geopolymer mortar.

Findings
The results derived from the experiments indicate that mortar and concrete made with 100% fly ash C require an alkaline solution to produce the same strength characteristics as Portland cement concrete. However, it was determined that increasing the amount of KOH generates too much heat causing the concrete to cure too quickly; therefore, it is notable to forming a proper bond. This study also determined that the addition of CNTs to the mix makes the concrete tougher than concrete without CNT.

Originality/value
This study was conducted at the construction engineering and management concrete laboratory at North Dakota State University in Fargo, North Dakota. All the experiments were conducted and analyzed by the authors.
Supplier relationship management and organizational performance of hospitals in an emerging economy context
Authors: Oduro Stephen , Nyarku Kwamena Minta , Gbadeyan Rotimi A. 
Published: February 2020

PurposeIntegrating the social exchange and resource dependency theories, the study aims to comparatively examine the supplier relationship management (SRM) dimensions and organizational performance links of private and public hospitals in Ghana.Design/methodology/approachComparative in nature; employing a quantitative approach; and using simple random and convenience sampling techniques, the study tested the proposed hypotheses using structural equation model-partial least square based on 205 usable questionnaires. Partial least square-multigroup analysis (PLS-MGA) was performed to test the significance of the difference in the parameters between the two samples: private and public hospitals in Ghana.FindingsThe dimensions of SRM (communication, cooperation, trust, atmosphere and adaptation) have a significant, positive impact on private hospitals’ performance in Ghana. Similarly, communication and trust were found to be positively and significantly correlated to public hospitals’ performance. In contrast, cooperation, atmosphere and adaptation dimensions showed no significant, positive effect on public hospitals’ performance. PLS-MGA disclosed that these observed differences in the findings between the private and public hospitals in Ghana are statistically significant.Research limitations/implicationsThe findings of the study, while limited to hospitals in Ghana, are likely to be relevant in other emerging economies for effective and enhanced supply chain relationship management.Practical implicationsThe findings provide pragmatic insights for marketing practitioners and organizational leaders of hospitals about the significance of SRM dimensions in today’s globalized marketplace, and how to nurture them to enhance organizational performance.Originality/valueThe value of the study lies in the examination of the relationship between SRM and organizational performance in the health sector by comparing private and public hospitals in an emerging economy context.
Barriers analysis for customer resource contribution in value co-creation for service industry using interpretive structural modeling
Authors: Roy Ghatak Ranjit 
Published: February 2020

PurposeCo-creating services with the customer has recently appeared as an alternative strategy to achieve competitive advantage. Developing and sustaining a gainful experience requires sharing of knowledge, skills and resources between the firm and its customers. Managing value co-creation throws substantial challenge and difficulties. This study aims to investigate the barriers to customer resource contribution in value co-creation in service industries and find their interrelationships for developing an effective management framework for removal of those barriers.Design/methodology/approachA systematic literature review led to the identification of 26 barriers, which were further confirmed through expert opinion. The study used interpretative structural modeling (ISM) approach and Matrice d’Impacts croises-multipication applique (MICMAC), for analyzing the contextual relationships and develop a hierarchical model of the barriers.FindingsISM approach led to the development of a 13-level structural model. The barriers were further classified into autonomous, driver, linkage and dependent barriers using the MICMAC analysis. The framework offers a means to fulfill the expectations of the customers, thus leading to successful integration of the customer in the value creation process. Removal of the barriers has also been discussed.Practical implicationsThe framework provides a direction and a tool to meet the expectations of the customers and lead to successful integration of the customer.Originality/valueThe study addresses a gap in the literature for the need of a structured framework for managing the value co-creation process in the service industry
Organizational learning, organizational resilience and the mediating role of multi-stakeholder networks
Authors: Mousa Mohamed , Abdelgaffar Hala A. , Chaouali Walid , Aboramadan Mohammed 
Published: February 2020

Purpose
This paper aims to focus on academics in three private foreign universities located in Cairo (Egypt) to explore the influence of organizational learning (OL) on the level of organizational resilience of academics with and without the mediating effect of a multi-stakeholder network.

Design/methodology/approach
The authors used a comprehensive count sampling in which every academic was handed a questionnaire form to fill. This led to a decrease in the likelihood of research bias. In total, the authors distributed 960 questionnaire forms and collected 576 completed questionnaires, which is almost more than 60% of the total population. The authors used structural equation to determine the effect of OL on academics’ level of organizational resilience. The same equation was later used to assess the mediating role of the multi-stakeholder network on the aforementioned relationship.

Findings
The findings highlight a statistically significant influence of OL on academics’ level of organizational resilience. Moreover, the results revealed the significant role of the multi-stakeholder network in mediating the relationship between OL and organizational resilience.

Originality/value
This paper contributes by filling a gap in human resource management and organization literature in the higher education sector, in which empirical studies on the relationship between OL, multi-stakeholder networks and organizational resilience have been limited until now.