bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of axitinib in metastatic head and neck cancer with novel radiographic response criteria
Authors: Swiecicki Paul L. , Bellile Emily L. , Brummel Collin V. , Brenner J. Chad , Worden Francis P. 
Published: October 2020

BackgroundThere are limited treatment options for unresectable recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). Vascular endothelial growth factor is of significant interest for targeted therapy in R/M HNSCC because of its central role in tumorigenesis and immunosuppression. Axitinib is a potent inhibitor of vascular endothelial growth factor receptor (VEGFR) 1 , VEGFR2, VEGFR3, platelet‐derived growth factor receptor, as well as c‐kit and offers such an approach.MethodsThis article reports the results of a phase 2 trial evaluating axitinib in R/M HNSCC according to the Choi criteria for radiographic response assessment. The primary endpoint of this trial was 6‐month overall survival.RESULTSTwenty‐nine patients were enrolled, and 28 were evaluable for a response. Patients were heavily pretreated with 61% having had at least 1 previous systemic treatment in the metastatic setting (range, 0‐5). The median overall survival of 9.8 months and the 6‐month overall survival rate of 70% met the protocol‐defined criteria for clinical efficacy. The best overall response rate was 42%. Correlative analyses demonstrated that PI3K signaling pathway alterations were associated with an increased response to therapy (75% vs 17%). A marked response to therapy was seen in a subgroup of patients who were treated with an immune checkpoint inhibitor after progression on axitinib.ConclusionsTreatment with axitinib is associated with improved survival in patients with heavily pretreated head and neck cancer, and PI3K pathway alterations may serve as a biomarker for response. Further investigation is warranted to evaluate axitinib in biomarker‐selected populations, especially in combination with immune checkpoint inhibitor therapy.Lay Summary

Metastatic head and neck squamous cancer is an incurable disease with limited treatment options and a poor prognosis.

This study is the first to demonstrate that the targeted oral drug axitinib improves survival in patients with heavily pretreated metastatic head and neck cancer.

Furthermore, patients whose tumors have specific mutations derive the greatest benefit from therapy.

The investigation of axitinib alone or in combination with immunotherapy in a genomic biomarker–selected population is warranted.
Conflict, what conflict? Evidence that playing down “conflict” can be a weapon of choice for high‐status groups
Authors: Livingstone Andrew G. , Sweetman Joseph , Haslam S. Alexander 
Published: October 2020

AbstractThree studies using pre‐existing (Studies 1 and 3) and minimal (Study 2) groups tested the hypothesis that ingroup status shapes whether “conflict’” with an outgroup is strategically acknowledged or downplayed. As predicted, high (vs. low) ingroup status led group members to downplay conflict, but only to an outgroup rather than ingroup audience (Studies 1 and 2; Ns = 127 & 292), and only when the status difference was unstable (vs. stable) and the outgroup's action was perceived as illegitimate (Study 2). High‐status group members also collectively communicated with the outgroup in a manner designed to defuse conflict (Study 2). Survey data of industrial (manager–worker) relations further indicated that company managers (high‐status) characterized manager–worker relations as less conflictual than did workers (low‐status) in the same companies (Study 3; N = 24,661). Findings imply that high‐status groups play down conflict as a “benevolent” (but unacknowledged) means of maintaining intergroup status hierarchies.
Comparative effect of silver nanoparticles (AgNPs) derived from actinomycetes and henna on biohydrogen production by Clostridium beijerinckii (KTCC1737)
Authors: Khan Imran , Anburajan Parthiban , Kumar Gopalakrishnan , Yoon Jeong‐Jun , Bahuguna Ashutosh , de Moura Alana Gandra Lima , Pugazhendhi Arivalagan , Kim Sang‐Hyoun , Kang Sun‐Chul 
Published: October 2020

SummaryThe current study comparatively evaluated the effects of silver nanoparticles (AgNPs) on fermentative bio hydrogen (bio‐H2) production by Clostridium beijerinckii (KTCC1737). Green synthesized AgNPs were fabricated using henna (Lawsonia inermis) and DU‐C2 actinomycete in batch using different AgNPs concentrations (0, 40, 80, and 120 μg/mL). The overall results revealed that after 72 hours of AgNPs incubation with C beijerinckii, the henna mediated AgNP synthesis increased the hydrogen production rate with a hydrogen yield of 1.71 mol H2/mol glucose added. However, the DU‐C2‐mediated AgNps synthesis inhibited bio‐H2 production during the batch H2 fermentation. Performed live/dead staining showed AgNPs effect on the bacterial culture in batch fermentation. The results indicated that the henna mediated AgNPs enhanced the bacterial cell population, meanwhile, in case of DU‐C2 AgNPs, less bacterial population occurred. Thus, the present study provides a clear overview on the application of metallic NPs as H2 production catalysts to further improve bio‐H2 production.
Forecasting equity returns: The role of commodity futures along the supply chain
Authors: Li Chenchen , Wu Chongfeng , Zhou Chunyang 
Published: October 2020

AbstractThis paper examines equity return predictability using the returns of commodity futures along the supply chain in China's financial market. We find that a considerable number of commodities exhibit significant in‐sample forecasting ability at the daily horizon, especially for supplier‐side equity returns. The macroeconomic risk premium effect, captured by the aggregate commodity prices, is an important source for this predictability. The out‐of‐sample results show that for most commodities, the predictability remains both statistically and economically significant, and the forecasting performance improves substantially during recessions or with economic constraints.
Cell populations in neonatal rat peripheral nerves identified by single‐cell transcriptomics
Authors: Zhang Ruirui , Chen Sailing , Wang Xinghui , Gu Xiaosong , Yi Sheng 
Published: October 2020

AbstractPeripheral nerves connect central nerves with target tissues and organs and execute vital signal transduction functions. Although sub‐types of neurons have been defined, the heterogeneity of cell populations in peripheral nerves, especially Schwann cells, has not been well demonstrated. Here, we collected sciatic nerves (SN) and dorsal root ganglia (DRG) from neonatal (1‐day old) rats and classified cell populations by high‐coverage single‐cell sequencing. A total of 10 types of cells, including endothelial cells, erythrocytes, fibroblasts, monocytic cells, neurons, neutrophils, pericytes, satellite cells, Schwann cells, and vascular smooth muscle cells, were identified by transcriptome‐based cell typing. The comparisons of cells in neonatal rat SN and DRG revealed distinct atlas in different tissue localizations. Investigations of ligand‐receptor interactions showed that there existed direct cell–cell communications between endothelial cells and fibroblasts in SN and among endothelial cells, fibroblasts, and vascular smooth muscle cells in DRG. Schwann cells in neonatal rats were further sub‐grouped to four sub‐types, including LOC100134871 and Hbb expressing Schwann cell sub‐type 1, Cldn19 and Emid1 expressing Schwann cell sub‐type 2, Timp3 and Col5a3 expressing Schwann cell sub‐type 3, and Cenpf and Mki67 expressing Schwann cell sub‐type 4. These Schwann cell sub‐types exhibited distinct genetic features and functional enrichments. Collectively, our results illustrated the diversity and cellular complexity of peripheral nerves at the neonatal stage and revealed the heterogeneity of Schwann cells in the peripheral nervous system.
A method for evaluating the longitudinal functional connectivity of a river–lake–marsh system and its application in China
Authors: Liu Yeling , Cui Baoshan , Du Jizeng , Wang Qing , Yu Shuling , Yang Wei 
Published: October 2020

AbstractThe longitudinal functional connectivity of a river–lake–marsh system (RLMS) refers to the actual water‐mediated transport of material from upstream to downstream areas along a spatial gradient and is fundamental to understand hydrological and biogeochemical cycles. However, due to a lack of consensus on appropriate data and methods, the quantification of connectivity is still a challenge, especially at the catchment scale. We developed a new method to evaluate longitudinal functional connectivity based on fluxes of materials (water, sediment, and chemicals) along a RLMS. The calculation of fluxes is based on the longitudinal pattern of terrain gradient, which influences transport efficiency, and on contributions from hillslopes, which set the initial spatial template of material loading to the RLMS. We evaluate the contributions from hillslopes to RLMS based on a new modified version of the index of sediment connectivity (IC) proposed by Borselli et al. (2008) and revised by Chartin et al. (2017).We applied this method to the Baiyangdian Basin covering an area of 3.4 × 104 km2 in China and quantified longitudinal functional connectivity during normal, wet, and dry periods(April, July and December) in year 2016. We found that areas with good structural connectivity exhibited poor functional connectivity during the normal and dry periods. Modelling testing with discharge data from hydrological stations and measured chemicals from Baiyangdian Lake was satisfactory in test periods. We conclude that public data and Digital Elevation Model‐derived information can be used to reliably map the longitudinal functional connectivity of RLMSs. The proposed method provides a useful tool for monitoring and restoring the longitudinal functional connectivity of RLMSs and our results indicate that efforts aimed at restoring functional connectivity in RLMSs should take into account landscape patterns that can greatly influence fluxes in the watershed.
Plerixafor‐based mobilization in pediatric healthy donors with unfavorable donor/recipient body weight ratio resulted in a better CD34+ collection yield: A retrospective analysis
Authors: Zubicaray Josune , Galvez Eva , Sebastian Elena , Molina Blanca , González‐Vicent Marta , Castillo Ana , Ramírez Manuel , Madero Luis , Díaz Miguel Angel , Sevilla Julian 
Published: October 2020

AbstractIntroductionIn order to propose risk‐adapted mobilization algorithms, several authors have tried to look for predictive factors of the CD34+ yield in healthy pediatric donors. Donor recipient body weight ratio (D/R ratio) was identified as one of the main variables related with the success to achieve the target cell dose for transplantation. According to this variable we modified the mobilization schedule.Material and methodsWe report the results of 46 mobilizations and apheresis procedures performed in our center with unfavorable D/R ratio. Mobilization was attempted by the standard regime of G‐CSF (10 mcg/kg/24 hours) in 28 cases (60.9%), with high dose G‐CSF (10 mcg/kg/12 hours) in 9 cases (19.6%), and with plerixafor and G‐CSF single dose regime in 9 cases (19.6%).ResultsCD34+ cell quantification before apheresis is closely related to CD34+ yield, being the only factor related to collected CD34+ cells (beta .71; P < .0001). The mobilization efficiency was higher in plerixafor group compared to the other two schedules (P < .0001). By using plerixafor for mobilization, we achieved the target CD34+ cell dose of ≥2 × 106/kg per recipient body weight in all cases with unfavorable D/R ratio. It was observed that 17.4% of cases that not reached the established target cell dose were located in the standard or high‐dose mobilization regimes. This difference is even greater for optimal collections (≥5 × 106/kg), since of the 54.3% cases that did not reach this goal none was mobilized by plerixafor.ConclusionTailoring the mobilization regime we can reach the target cell dose, even in those cases with the worst D/R ratio.
Estimating the ligand‐binding affinity via λ‐dependent umbrella sampling simulations
Authors: Ngo Son Tung 
Published: October 2020

AbstractThe umbrella sampling (US) approach has been demonstrated to be a very efficient method for estimating the ligand‐binding affinity. However, most of the calculated values overestimate experimental ones that are probably caused by the inaccurate representation of the interaction between the ligand and the surrounding molecules. The issue can be resolved via the implementation aspects of λ‐alteration simulation into the US approach, which we call the λ‐dependent umbrella sampling (λUS) scheme. In particular, the electrostatic and van der Waals interactions were simultaneously changed by using the coupling parameter λ during λUS simulations. The mean value of obtained results, kcal mol−1, is in good fitting to the mean value of respective experiments, ∆GEXP =  − 11.26 ± 0.89 kcal mol−1. Moreover, the correlation between the proposed approach and experiment is quite good with a value of . The λUS scheme significantly enhances the calculated accuracy since the RMSE of the proposed scheme is smaller than traditional US simulations, kcal mol−1 versus kcal mol−1. Furthermore, the precision is increased since the computed error via λUS approach, kcal mol−1, was smaller than those of the US simulation, kcal mol−1. Overall, the proposed approach perhaps provides an efficient way to accurately and precisely estimate the ligand‐binding free energy.
Design, synthesis, in silico analysis with PPAR‐γ receptor and study of non‐covalent interactions in unsymmetrical heterocyclic/phenyl fleximer
Authors: Singh Ved Prakash , Dowarah Jayanta , Marak Brilliant N. , Tewari Ashish Kumar 
Published: October 2020

AbstractThis work deals with the design, synthesis, in silico analysis, crystallization, and the interpretation 2‐cyano‐3‐{4‐[2‐(phthalimid‐nyl)‐propoxy]‐phenyl}‐acrylic acid ethyl ester (7). Analog 7 is designed based on rosiglitazone. The quantitative analysis of Compound 7 has been performed through single‐crystal X‐Ray Diffraction (XRD) and Hirshfeld surface analysis. Fleximer 7 has studied the role of flexibility in non‐covalent interactions and binding affinity with PPAR‐γ receptors. Both phthalimide ring and phenyl rings are linked with propylene linker. 2‐cyano‐3‐{4‐[2‐(phthalimid‐nyl)‐propoxy]‐phenyl}‐acrylic acid ethyl ester has Z = 8 in the crystal packing and stabilized by intermolecular non‐covalent interactions like CH…O, CH…N, CH…л, and л…л, and so forth.
Pick Your Poison: Attribute Trade‐Offs in Unattractive Consideration Sets
Authors: Sokolova Tatiana , Krishna Aradhna 
Published: October 2020

Consumers often have to make trade‐offs between desirable, “more is better,” and undesirable, “less is better,” attributes. What drives whether the desirable or the undesirable attributes will be weighed more heavily in decisions? We show that the extent to which consumers focus on desirable versus undesirable attributes depends on the overall attractiveness of their consideration sets. The less attractive the options under consideration are—the higher is the weight allocated to undesirable attributes, such as price. Three experiments set in the contexts of lottery ticket purchasing (study 1), hotel booking (study 2), elections (study 3), and a conjoint study of online course evaluations (study 4) (N = 2,149, p‐curve power estimate 90%), demonstrate that unattractive sets increase the relative weight of “undesirable” attributes (e.g., price of a product, workload of a course) and lead to increased preference for options superior on these attributes.
Pancreatitis in multiple acyl CoA dehydrogenase deficiency: An underdiagnosed complication
Authors: Elkhateeb Nour , Chakrapani Anupam , Davison James , Grunewald Stephanie , Batzios Spyros 
Published: October 2020

AbstractBackgroundMultiple acyl‐CoA dehydrogenase (MADD) deficiency represents a rare fatty acid oxidation disorder where sporadic reports of pancreatitis already exist. Here, we report three cases of MADD with pancreatic involvement raising questions whether this represents an incidental finding or it is related to the pathophysiology of MADD.MethodsWe have retrospectively studied the clinical, biochemical and radiologic data of patients with MADD diagnosed in our department over the last 20 years to identify patients with pancreatic involvement.RESULTSThree out of 17 patients had pancreatic involvement. All three patients were diagnosed with MADD in the neonatal period (two‐third symptomatic—riboflavin nonresponsive, one‐third asymptomatic via newborn screening—riboflavin responsive). Age at presentation of pancreatitis ranged from 20 months to 11 years. Presentations included a single episode of acute pancreatitis in the first patient, chronic necrotizing pancreatitis in the second patient, while the third patient was diagnosed with chronic pancreatitis (CP) incidentally through ultrasonography. All patients had inflammation features on either abdominal computed tomography or ultrasound. Pancreatic enzymes were elevated in two patients. Management of pancreatitis was done conservatively while the patient with necrotic CP required subtotal pancreatectomy.DISCUSSIONOur data suggest that pancreatitis might be more common in patients with MADD than previously reported, requiring a high index of suspicion in patients with acute metabolic decompensation or nonspecific abdominal symptoms. We hypothesize that the underlying mechanism of pancreatitis in MADD is similar to that in mitochondrial disorders, both resulting from disordered energy metabolism and oxidative phosphorylation.
The Impact of Hazardous Drinking Among Active Duty Military With Posttraumatic Stress Disorder: Does Cognitive Processing Therapy Format Matter?
Authors: Straud Casey L. , Dondanville Katherine A. , Hale Willie J. , Wachen Jennifer S. , Mintz Jim , Litz Brett T. , Roache John D. , Yarvis Jeffrey S. , Young‐McCaughan Stacey , Peterson Alan L. , Resick Patricia A. ,   for the STRONG STAR Consortium
Published: October 2020

AbstractThis study was a secondary data analysis of clinical trial data collected from 268 active duty U.S. military service members seeking cognitive processing therapy (CPT) for posttraumatic stress disorder (PTSD) at Fort Hood, Texas, related to combat operations following September 11, 2001. Our primary aim was to evaluate changes in PTSD symptom severity and alcohol misuse as a function of baseline hazardous drinking and treatment format (i.e., group or individual). At baseline and posttreatment, PTSD was assessed using the PTSD Symptom Scale–Interview Version and PTSD Checklist for DSM‐5. Hazardous drinking was categorically defined as an Alcohol Use Disorder Identification Test total score of 8 or higher. Employing intent‐to‐treat, mixed‐effects regression analysis, all groups reported reduced PTSD symptom severity, Hedges’ gs = −0.33 to −1.01, except, unexpectedly, nonhazardous drinkers who were randomized to group CPT, Hedges’ g = −0.12. Hazardous drinkers who were randomized to individual therapy had larger reductions in PTSD symptoms than nonhazardous drinkers who were randomized to group CPT, Hedges’ g = −0.25. Hazardous drinkers also reported significant reductions in alcohol misuse, regardless of treatment format, Hedges’ gs = −0.78 to −0.86. This study builds upon an emerging literature suggesting that individuals with PTSD and co‐occurring alcohol use disorder can engage successfully in CPT, which appears to be an appropriate treatment for these individuals whether it is delivered individually or in a group format. However, as a portion of participants remained classified as hazardous drinkers at posttreatment, some individuals may benefit from integrated treatment.
Optically Stimulated Luminescence Phosphors: Principles, Applications, and Prospects
Authors: Yuan Lifang , Jin Yahong , Su Yue , Wu Haoyi , Hu Yihua , Yang Shihe 
Published: October 2020

AbstractOptically stimulated luminescence (OSL) materials, enabling energy storage by capturing of charge carriers and then the energy conversion to light via photostimulation, can find many advanced applications in various fields, spanning from radiation dosimetry, optical data storage and security, environmental monitoring, biomedicine, clinical diagnostic, to archaeology and geology. At present, there are some blocks, including the development of nanocrystallization approaches, the tailoring of optical transitions, the control of trap distribution, and the understanding of OSL mechanisms, on the road to the exploration of OSL materials. This review gives an overview of the design, preparation, characterization, optimization, application, mechanism, and prospect of OSL materials. A short introduction of the fundamental principle and history of OSL materials is presented, followed by a summary of preparation and design methods, and a survey of OSL materials reported to date. The trap engineering, mechanism, and study methodologies of OSL are summarized, after which the widespread applications of OSL materials, in traditional and newly emerging fields, are reviewed. Finally, the merits and drawbacks of the OSL materials according to the relevant reports currently available are examined. The challenges and outlooks are highlighted and discussed in terms of five important aspects that merit future research.
Dynamic in vivo protein carbonyl biosensor for measuring oxidative stress
Authors: Kostecki Roman , Arman Azim , Zhang Bin , Yang Kai‐Hung , Narayan Roger J. , Hutchinson Mark R. , Ebendorff‐Heidepriem Heike 
Published: October 2020

AbstractOxidative stress is intimately linked to cellular energy balance and occurs when there is an imbalance between production and accumulation of reactive oxygen species in cells and tissues and the ability of a biological system to keep in a redox steady state. While protein carbonyls are an easily detectable marker of oxygen metabolism and oxidative stress, all methods to date have required significant sample preparation and do not provide the ability to measure dynamic changes. To overcome this problem, we develop the first method for measuring in vivo concentration changes of protein carbonyls using a minimally invasive optical fibre biosensor. We use this biosensor to measure redox balance and oxidative stress within living systems by measuring dynamic in vivo concentration changes of protein carbonyls.