bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and Sociodemographic Factors Associated With Human Donor Milk Supplementation in Term Newborns
Authors: McKittrick Megan M. , Khaki Sheevaun , Gievers Ladawna , Larson Ilse A. 
Published: June 2020

OBJECTIVES:
To identify differences between healthy term newborns supplemented with human donor milk (HDM) and those supplemented with infant formula. We hypothesized that sociodemographic and clinical distinctions exist between newborns receiving different milk types.

METHODS:
This retrospective study included term newborns admitted to the postpartum unit between March 2017 and April 2019 with ≥1 supplemental feeding with HDM or formula for indications other than hypoglycemia. Maternal and newborn data were abstracted from the electronic medical record.

RESULTS:
Five hundred eighty-four dyads met inclusion criteria. More newborns received supplementation with formula than with HDM (57.7% vs 42.3%; P &lt; .001). Infants undergoing phototherapy who required supplementation were more likely to receive HDM (P &lt; .001). Newborns born to white and non-Hispanic mothers were more likely to receive HDM than those born to African American (adjusted odds ratio [aOR] 5.6; P = .007), Hispanic (aOR 3.0; P = .001), or Asian American mothers (aOR 2.7; P = .007). Newborns born to primiparous women (aOR 1.6; P = .03), those born to women with private insurance (aOR 3.7; P &lt; .001), and those born via cesarean delivery (aOR 2.0; P &lt; .001) were more likely to receive HDM. HDM use was more likely in primary English- or Spanish-speaking households (aOR 8.5; P = .009). Newborns receiving their first supplemental feeding during the day (aOR 1.9; P = .001) were more likely to be supplemented with HDM.

CONCLUSIONS:
There are clinical and sociodemographic differences between healthy term newborns supplemented with HDM and formula. These findings reveal that there are disparities in current supplementation practices for healthy newborns.
Evaluation for Neonatal HSV in Infants Undergoing Workup for Serious Bacterial Infection: A 5-Year Retrospective Review
Authors: Brower Laura H. , Wilson Paria M. , Murtagh-Kurowski Eileen , Courter Joshua D. , Shah Samir S. , Schondelmeyer Amanda C. 
Published: June 2020

OBJECTIVES:
To describe the characteristics of infants evaluated for serious bacterial infection, focusing on empirical testing and treatment of herpes simplex virus (HSV) and describe the characteristics of HSV-positive patients.

METHODS:
We included infants aged 0 to 60 days undergoing evaluation for serious bacterial infection in the emergency department. This descriptive study was conducted between July 2010 and June 2014 at a tertiary-care children’s hospital. Eligible patients were identified on the basis of age at presentation to the hospital and laboratory specimens. Infant characteristics, symptoms on presentation, and laboratory workup were compared between HSV-positive and HSV-negative patients by using the 2-sample t test or the Wilcoxon rank test.

RESULTS:
A total of 1633 infants were eligible for inclusion, and 934 (57.2%) were 0 to 28 days of age. HSV was diagnosed in 19 infants, 11 of whom had disseminated disease. Compared with those without HSV, HSV-positive infants were younger, less likely to be febrile and to present with nonspecific symptoms, and more likely to have a mother with HSV symptoms (P &lt; .05). Testing from all recommended locations was only performed in 22% of infants. Infants tested or empirically treated with acyclovir had a longer median length of stay compared with children who were not tested or treated (P &lt; .01).

CONCLUSIONS:
The absence of fever should not preclude a workup for HSV in neonates, and when a workup is initiated, emphasis should be placed on obtaining samples from serum, cerebrospinal fluid, and surface specimens. Physicians may benefit from a guideline for evaluation of HSV with specific guidance on high-risk features of presentation and recommended testing.
Supporting Breastfeeding in Infants Hospitalized for Jaundice
Authors: Kovaric Kelly , Cowperthwaite Matthew , McDaniel Corrie E. , Thompson Grace 
Published: June 2020

BACKGROUND:Infants readmitted for neonatal hyperbilirubinemia requiring phototherapy are less likely to exclusively breastfeed than infants who are not readmitted for phototherapy. Our aim for this study was to increase breastfeeding exclusivity for infants admitted for neonatal hyperbilirubinemia.METHODS:Using the Model for Improvement, we conducted 3 plan-do-study-act cycles to improve exclusive breastfeeding (EB). Our outcome measure was to increase the percentage of EB for infants hospitalized for phototherapy from 30% to 80% in 12 months. Our process measure was to increase lactation consultations from 60% to 80%. Balancing measures included the development of &gt;10% weight loss, acute bilirubin encephalopathy, readmissions, and length of stay. Interventions involved staff breastfeeding education, automated orders for lactation consultations, and use of bilirubin blankets during breastfeeding. Data were analyzed by using run charts and statistical process control.RESULTS:A total of 92 infants with neonatal hyperbilirubinemia were admitted from December 2016 to August 2019, with 61 in the postintervention period. After implementation of an automated order for lactation consultation, EB improved from 30% to 60% and completed lactation consultations increased from 60% to 90%. Infants who received a lactation consultation within the first shift during their hospitalization were 4 times more likely to have EB during hospitalization than infants who did not (odds ratio 3.8; confidence interval: 1.17–12.39.) No infant experienced &gt;10% weight loss, acute bilirubin encephalopathy, or a readmission, and length of stay did not significantly change.CONCLUSIONS:Early involvement of trained lactation consultants safely improves rates of EB for infants hospitalized with neonatal hyperbilirubinemia.
Developing Appropriateness Criteria for Pediatric Vascular Access
Authors: Ullman Amanda J. , Chopra Vineet , Brown Erin , Kleidon Tricia , Cooke Marie , Rickard Claire M. , Bernstein Steven J. 
Published: June 2020

OBJECTIVES:
To describe the methodology undertaken to provide guidance on the appropriateness, as well as inappropriateness, of vascular access device selection, characteristics, and insertion technique for pediatric patients.

METHODS:
The RAND Corporation–University of California, Los Angeles Appropriateness Method was used. After definition of key terms and scope, a systematic review of the pediatric vascular access literature was undertaken. Clinical scenarios were developed to reflect the common indications for vascular access across pediatric health care. These were sectioned according to (1) device selection, (2) device characteristics, and (3) insertion technique. An interdisciplinary panel of experts (N = 14) consisting of leading experts representing diverse pediatric clinical disciplines including anesthesiology, cardiology and cardiac surgery, critical care and emergency, general surgery, hematology and oncology, hospital medicine, infectious disease, interventional radiology, pharmacology, regional pediatric hospitalist, and vascular access nursing specialties was convened. The scenarios were rated for appropriateness by the panel over 2 rounds (1 [highly inappropriate] to 9 [highly appropriate]). Round 1 ratings were completed anonymously and independently by panel members and classified into 3 levels of appropriateness: appropriate, uncertain, and inappropriate, or disagreement. For round 2, panelists met in-person to discuss the round 1 ratings and independently rerated the indications. All indications were reclassified into 3 levels of appropriateness or disagreement.

CONCLUSIONS:
The RAND Corporation–University of California, Los Angeles Appropriateness Method provides a rigorous, in-depth and transparent methodology to develop the first appropriateness criteria for the selection of pediatric vascular access devices in a range of patient groups.
The Michigan Appropriateness Guide for Intravenous Catheters in Pediatrics: miniMAGIC
Authors: Ullman Amanda J. , Bernstein Steven J. , Brown Erin , Aiyagari Ranjit , Doellman Darcy , Faustino E. Vincent S. , Gore Beth , Jacobs Jeffrey P. , Jaffray Julie , Kleidon Tricia , Mahajan Prashant V. , McBride Craig A. , Morton Kayce , Pitts Stephanie , Prentice Elizabeth , Rivard Douglas C. , Shaughnessy Erin , Stranz Marc , Wolf Joshua , Cooper David S. , Cooke Marie , Rickard Claire M. , Chopra Vineet 
Published: June 2020

OBJECTIVES:
Vascular access device decision-making for pediatric patients remains a complex, highly variable process. To date, evidence-based criteria to inform these choices do not exist. The objective of the Michigan Appropriateness Guide for Intravenous Catheters in pediatrics (miniMAGIC) was to provide guidance on device selection, device characteristics, and insertion technique for clinicians, balancing and contextualizing evidence with current practice through a multidisciplinary panel of experts.

METHODS:
The RAND Corporation and University of California, Los Angeles Appropriateness Method was used to develop miniMAGIC, which included the following sequential phases: definition of scope and key terms, information synthesis and literature review, expert multidisciplinary panel selection and engagement, case scenario development, and appropriateness ratings by an expert panel via 2 rounds.

RESULTS:
The appropriateness of the selection, characteristics, and insertion technique of intravenous catheters commonly used in pediatric health care across age populations (neonates, infants, children, and adolescents), settings, diagnoses, clinical indications, insertion locations, and vessel visualization devices and techniques was defined. Core concepts including vessel preservation, insertion and postinsertion harm minimization (eg, infection, thrombosis), undisrupted treatment provision, and inclusion of patient preferences were emphasized.

CONCLUSIONS:
In this study, we provide evidence-based criteria for intravenous catheter selection (from umbilical catheters to totally implanted venous devices) in pediatric patients across a range of clinical indications. miniMAGIC also highlights core vascular access practices in need of collaborative research and innovation.
Does the Sequence of Anthracycline and Taxane Matter? The NeoSAMBA Trial
Authors: Bines José , Small Isabele A , Sarmento Roberta , Kestelman Fabiola , Silva Silvania , Rodrigues Fabiana Resende , Faroni Lilian , Gonçalves Aline , Ebecken Erika , Maroun Pedro , Millen Eduardo , Bonamino Martin 
Published: June 2020

Abstract

Background
Taxanes usually follow anthracyclines in breast cancer neo/adjuvant treatment, likely because of their later introduction into clinical practice. However, there is no biological rationale that justifies this current standard of care. We compared a taxane followed by an anthracycline-based regimen with the reverse sequence in the neoadjuvant setting.

Patients and Methods
In a randomized, open-label, single-center phase II trial, women with inoperable, locally advanced, HER2-negative breast cancer were stratified by hormone receptor status and randomized to three cycles of docetaxel (T) followed by three cycles of fluorouracil, doxorubicin, and cyclophosphamide (FAC) versus three cycles of FAC followed by three cycles of docetaxel. Surgery, radiotherapy, and adjuvant hormonal therapy were administered as per local guidelines. The primary endpoint was pathological complete response (pCR), and secondary endpoints included toxicity, event-free survival (EFS), and overall survival (OS).

Results
Treatment sequence did not improve pCR, which was 7% with T-FAC and 3% with FAC-T. However, after a median follow-up of 79 months, the 5-year EFS rate was 75.7% (95% confidence interval [CI], 65.4%–87.7%) with T-FAC and 48.2% (95% CI, 37.0%–62.7%) with FAC-T (hazard ratio [HR], 0.46; 95% CI, 0.26–0.81; log-rank p = .0054), and the 5-year OS rate was 89.7% (95% CI, 82.2%–97.8%) with T-FAC and 64.7% (95% CI, 53.6%–78.1%) with FAC-T (HR, 0.41; 95% CI, 0.22–0.78; p = .0052). There were no unexpected toxicities.

Conclusion
We showed for the first time an improvement in EFS and OS with taxane-first compared with anthracycline-first sequencing chemotherapy in HER2-negative, locally advanced breast cancer. Confirmation of these results may have implications for clinical practice.
This trial was registered with Clinicatrials.gov identifier NCT01270373.

Implications for Practice
The NeoSAMBA trial showed a benefit for taxane-first sequencing chemotherapy consistent with the systematic review of the literature as well as the larger Neo-tAnGo study. Many recent and current ongoing clinical trials have already followed this treatment strategy. As a taxane-before-anthracycline sequence carries neither an incremental cost nor an increased toxicity, and given the available literature on this issue, reinforced that taxane-first regimen can be easily incorporated into daily clinical practice while awaiting confirmation of these findings from larger trials.
Prognostic Value of Modified IHC4 Score in Patients with Estrogen Receptor-Positive Metastatic Breast Cancer
Authors: Jin Liang , Chen Kai , Tan Cui , Li Jianbin , Luo Jiayue , Yang Yaping , Li Yudong , Li Shunying , Zhu Liling , Hu Yue , Liu Fengtao , You Qiuting , Peng Min , Jiang Zefei , Liu Qiang 
Published: June 2020

Abstract

Background
This study aimed to investigate whether an immunohistochemical prognostic model (IHC4 score) can predict the prognosis and the chemotherapy benefit in patients with estrogen receptor-positive (ER+)/human epidermal growth receptor 2–negative (HER2−) metastatic breast cancer (MBC).

Materials and Methods
We developed a method to calculate the modified IHC4 (mIHC4) scores based on routine pathological reports and compared them with the original IHC4 scores that were much more difficult to calculate. Univariate and multivariate analyses were used to study the prognostic factors of progression-free survival (PFS) and overall survival (OS). The predictive value of mIHC4 score was also investigated.

Results
The Sun Yat-sen Memorial Hospital data set included 315 patients with newly diagnosed ER+ MBC with a median follow-up of 25.6 months. Univariate and multivariate analysis showed that higher mIHC4 scores in metastatic lesions, but not the ones in primary tumors, were significantly associated with worse PFS and OS. The prognostic value of mIHC4 scores for PFS was validated using an independent Chinese Society of Clinical Oncology- Breast Cancer (CSCO-BC) data set. More importantly, subpopulation treatment effect pattern plot analysis showed that first-line endocrine therapy achieved better PFS and OS than chemotherapy in low-risk patients with ER+/HER2− MBC, whereas first-line chemotherapy was associated with improved PFS and OS compared with endocrine therapy in high-risk ones. The predictive value of mIHC4 score for PFS in selecting first-line endocrine therapy versus chemotherapy was also confirmed in the CSCO-BC data set.

Conclusion
mIHC4 scores in metastatic lesions are prognostic for the PFS and OS in patients with ER+ MBC. Low or high mIHC4 score may indicate the survival benefit in choosing first-line endocrine therapy or chemotherapy in patients with ER+/HER2− MBC, respectively.

Implications for Practice
The modified IHC4 (mIHC4) score is easy to implement and able to predict patients with advanced and/or metastatic breast cancer. In addition, with the help of the mIHC4 score, physicians might be able to recommend chemotherapy or endocrine therapy as the first-line treatment for patients with high and low risk as predicted by the mIHC4 score.
Outdoor Education dan Self Concept
Authors: Satria Teguh , Nur Lutfi 
Published: June 2020

The deviation of social behavior of elementary school students lately is very alarming, it requires preventive and curative efforts in handling it.The focus of this study would like to see the contribution of outdoor education activities to students' self concept in the primary school of the UPI Campus Tasikmalaya Campus, Indonesia. 32 students were selected as samples through purposive sampling technique. The experimental method was used in this study. Data obtained through self concept scale questionnaire. The results of the study mentioned Outdoor Education activities contributed to the development of self concept. This finding can be used as an alternative by physical education teachers in the context of innovation and learning variation. Further research can be carried out on the development of other affective aspects such as assertive behavior. Abstrak Penyimpangan perilaku sosial siswa sekolah dasar akhir-akhir ini sangat memprihatinkan, diperlukan upaya preventif dan kuratif dalam menanganinya. Fokus penelitian ini ingin melihat kontribusi aktivitas outdoor education terhadap self concept siswa di sekolah dasar laboratorium percontohan UPI Kampus Tasikmalaya, Indonesia. Sebanyak 32 siswa dipilih menjadi sampel melalui teknik purposive sampling. Metode eksperimen digunakan dalam penelitian ini. Data diperoleh melalui kuesioner skala self concept. Hasil penelitian menyebutkan aktivitas Outdoor Education memberikan kontribusi terhadap pengembangan self concept. Temuan ini dapat dijadikan alternatif oleh para guru pendidikan jasmani dalam rangka inovasi dan variasi pembelajaran. Penelitian selanjutnya dapat dilakukan terhadap pengembangan aspek afektif lainnya seperti perilaku assertif.
Strategi Pengembangan Usaha Ternak Kambing Potong Abu Aqiqah di Kecamatan Krueng Barona Jaya Kabupaten Aceh Besar
Authors: Daus Firdaus , Makmur Teuku , Irwan Irwan 
Published: June 2020

Tujuan penelitian ini ialah Mengidentifikasi faktor-faktor internal dan eksternal pada usaha ternak kambing potong. Dan Mengidentifikasi strategi alternatif yang tepat untuk mengembangkan usaha ternak kambing potong. Metode penelitian yang digunakan ialah metode studi kasus mengunakan data primer dan data sekunder.Sedangkan metode analisis yang digunakan adalah metode deskriptif dan analisis strategi pengembangan.Berdasarkan hasil strategi yang dapat dijalankan adalah strategi intensif dan intergratif .Strategi yang menjadi prioritas utama yang dapat dilakukan oleh usaha Abu Aqiqah adalah meningkatkan modal guna mengembangakan teknologi.strategi tersebut merupakan strategi yang palik baik menurut penilaian STAS tertinggi 6,67. Meningkatkan modal usaha merupakan hal yang sangat penting untuk diperhatikan dalam mengembangkan usaha karena adanya proses yang dapat memudahkan usaha serta memudahkan dalam pemasaran . Dengan meningkatkan modal juga akan mendukung strategi-strategi yang lain seperti peningkatkan SDM tenaga kerja dalam hal penggunaan teknologi baru ,meningkatkan kapasitas pemasaran ternak . Semua strategi saling berkaitan dan dapat mendorong dalam upaya pengembangan usaha ternak kambing Abu Aqiqah kedepannya.Kata kunci :Strategi, Pengembangan, Faktor Internal, Faktor Eksternal,Ternak Kambing.
Uji Daya Hasil S5 Jagung (Zea mays L.) Hibrida
Authors: Roslini Nur , Bakhtiar Bakhtiar , Hafsah Siti 
Published: June 2020

Abstrak. Penelitian ini bertujuan untuk menyeleksi tanaman jagung berdaya hasil tinggi. Penelitian ini dilaksanakan di PT Syngenta Seed Indonesia Kediri Field Station dusun Sukodono desa Kedungmalang kecamatan Papar kabupaten Kediri, Jawa Timur yang berlangsung pada Mei sampai Oktober 2019. Rancangan yang digunakan dalam penelitian ini adalah Rancangan Acak Kelompok (RAK) non faktorial dengan 24 genotipe uji, 4 genotipe pembanding (untuk uji daya hasil) dengan 2 ulangan. Pada uji daya hasil diperoleh 7 genotipe yaitu 18ID010144, 18ID010123, 18ID006020, 18ID010135, 18ID010125, 18ID007419 dan 18ID010148 yang memiliki daya hasil tinggi diatas genotipe pembanding daya hasil tertinggi. 24 genotipe uji yaitu 18ID010125 memiliki daya hasil 14,12 ton ha-1 genotipe 18ID010123 memiliki daya hasil tertinggi 15,28 ton ha-1 dan genotipe 18ID010148 memiliki daya hasil 13,91 ton ha-1. Yield Trial Screening on S5 Hybrid Maize (Zea mays L.)Abstract. This research aims to select maize are high yield. This research was conducted at PT Syngenta Seed Indonesia Kediri Field Station Sukodono in Sukodono sub-village, Kedungmalang village, Papar district, Kediri district, East Java, which took place from May to October 2019. The design used in this research was Non Factorial Randomized Block Design (RBD) with 24 test genotypes, 4 comparative genotypes (for yield trial) with 2 replications. The results showed that In yield trial was obtained 7 genotypes (18ID010144, 18ID010123, 18ID006020, 18ID010135, 18ID010125, 18ID007419 dan 18ID010148) which have high yields above the highest comparative yield genotypes. There were 3 genotypes selected from 24 test genotypes consist 18ID010125 has yield 14,12 tons ha-1,genotype 18ID010123 has the highest yield 15,28 tons ha-1 and genotype 18ID010148 has yield 13,91 tons ha-1.
Pengaruh Jenis Mikoriza terhadap Pertumbuhan dan Hasil Beberapa Varietas Cabai Merah (Capsicum annuum L.) pada Tanah Andisol Lembah Seulawah Aceh Besar
Authors: Kamal Muhammad Irfan , Syamsuddin Syamsuddin , Syafruddin Syafruddin 
Published: June 2020

Abstrak. Penelitian ini bertujuan untuk mengetahui pengaruh jenis mikoriza terhadap pertumbuhan dan hasil beberapa varietas cabai merah di tanah Andisol. Penelitian ini dilakukan pada bulan Mei hingga Oktober 2019 di Kecamatan Lembah Seulawah, Kabupaten Aceh Besar dan Rumah Kaca Fakultas Pertanian lalu analisis dilakukan di Laboratorium Ilmu dan Teknologi Benih dan Laboratorium Fisiologi Tumbuhan Fakultas Pertanian Universitas Syiah Kuala, Banda Aceh. Analisis data yang digunakan adalah Rancangan Acak Kelompok (RAK) pola faktorial 3 x 3 dengan 3 ulangan sehingga didapat 9 kombinasi perlakuan dengan 3 ulangan mencakup 27 unit percobaan. Faktor yang diteliti yaitu pupuk hayati jenis mikoriza yang terdiri dari 3 taraf (Glomus mosseae, Gigaspora sp. dan campuran antara Glomus mosseae and Gigaspora sp.) dan varietas yang terdiri dari 3 taraf (PM 999 F1, Lado F1, dan Perintis). Hasil penelitian ini adalah perlakuan jenis mikoriza berpengaruh terhadap parameter tinggi tanaman 15, 30 dan 45 HST, diameter batang 30 dan 45 HST, jumlah cabang produktif 60 HST, berat basah tanaman, berat kering tanaman, berat basah akar, berat kering akar, berat buah, panjang buah, jumlah buah, dan potensi hasil serta berpengaruh nyata terhadap diameter batang 15 HST dan persentase kolonisasi mikoriza. Effect of Mycorrhiza Type on Growth and Yields Several Varieties of Red Chili (Capsicum annuum L.) in Andisol Soil Seulawah Valley of Aceh Besar Abstract. This research aims to determine the effect of mycorrhiza type on the growth and yield several varieties of red chili on Andisol soil. This research was conducted from May to October 2019 in Lembah Seulawah District, Aceh Besar District and Greenhouse, and analysis was conducted at the Seed Science and Technology Laboratory and Plant Physiology Laboratory, Faculty of Agriculture, Syiah Kuala University, Banda Aceh. Analysis of the data used in this study was 3 x 3 Factorial Randomized Block Design with 3 replications so that 9 treatment combinations were obtained with 3 replications covering 27 experimental units. Factors studied were mycorrhiza biofertilizers consisting of 3 levels (Glomus mosseae, Gigaspora sp. And a mixture of Glomus mosseae and Gigaspora sp.) and varieties consisting of 3 levels (PM 999 F1, Lado F1, and Perintis). The results of this study are the treatment of mycorrhiza type has a very significant effect on plant height parameters 15, 30 and 45 DAP, stem diameter 30 and 45 DAP, number of productive branches 60 DAP, plant wet weight, plant dry weight, root wet weight, root dry weight, fruit weight , fruit length, number of fruits, and yield potential and also have a significant effect on stem diameter 15 DAP and percentage of mycorrhiza colonization.