bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticoagulants and Breast Cancer Survival: A Nationwide Cohort Study
Authors: Kinnunen Pete T. , Murto Mika O. , Artama Miia , Pukkala Eero , Visvanathan Kala , Murtola Teemu J. 
Published: October 2019

AbstractBackground:Various components of the coagulation cascade have been linked to breast cancer progression. In vivo results suggest that anticoagulants possess anticancer properties, but there are virtually no studies in human populations. Our nationwide study explored the association between anticoagulant use and breast cancer survival.Methods:All anticoagulants used from 1995 to 2015 in women (n = 73,170) diagnosed with invasive breast cancer in Finland between 1995 and 2013 were identified from the national prescription database; women were identified from the Finnish Cancer Registry. Cox regressions were performed to analyze breast cancer survival as a function of pre- and postdiagnostic anticoagulant use; analyses were conducted for different anticoagulant subtypes and overall. Models were adjusted for age, mammography screening, tumor clinical characteristics, comorbidities, statin use, antidiabetic use, and antihypertensive use. To control for immortal time bias, postdiagnostic anticoagulant use was analyzed as a time-dependent variable.Results:At a median of 5.8 years after breast cancer diagnosis, 10,900 (15%) women had died from breast cancer. In total, 25,622 (35%) women had used anticoagulants during the study period. Postdiagnostic anticoagulant use increased the risk of breast cancer death (HR = 1.41; 95% confidence interval, 1.33–1.49). The risk was especially high for low-molecular weight heparin, although the effect disappeared in long-term users.Conclusions:Anticoagulant use provides no clinical benefit for breast cancer survival; however, the association between thrombosis and cancer might mask potential survival benefits.Impact:Future pharmacoepidemiologic studies should adjust for anticoagulant use. Research should focus on the use of new oral anticoagulants because these are rarely studied and might be associated with improved breast cancer survival.
Prevention of Colorectal Carcinogenesis by DNA-Binding Small-Molecule Curaxin CBL0137 Involves Suppression of Wnt Signaling
Authors: Kirsanov Kirill , Fetisov Timur , Lesovaya Ekaterina A. , Maksimova Varvara , Trukhanova Lubov , Antoshina Elena , Gor'kova Tatiana , Morozova Olga , Safina Alfiya , Fleyshman Daria , Salimov Ramiz , Shipaeva Elena , Ivanov Roman , Leonov Andrey , Purmal Andrei A. , Belitsky Gennady A. , Gudkov Andrei V. , Gurova Katerina V. , Yakubovskaya Marianna G. 
Published: October 2019

Abstract
Chemoprevention is considered a valid approach to reduce the incidence of colorectal cancer, one of the most common malignancies worldwide. Here, we investigated the tumor-preventive activity of curaxin CBL0137. This compound represents a new class of nonmutagenic DNA-binding small molecules that alter chromatin stability and inhibit the function of the histone chaperone FACT. Among downstream effects of CBL0137 treatment are activation of p53 and type I interferons and inhibition of NFκB, HSF1, and MYC. In addition, our data show that in both human and mouse colorectal cancer cells in vitro, CBL0137 inhibits the APC/WNT/β-catenin signaling pathway, which plays a key role in colon carcinogenesis. Using quantitative RT-PCR and microarray hybridization, we have demonstrated decreased expression of multiple components and downstream targets of the WNT pathway in colon cancer cells treated with CBL0137. At the same time, CBL0137 induced expression of WNT antagonists. Inhibition of WNT signaling activity by CBL0137 was also confirmed by luciferase reporter assay. Tumor-preventive activity of CBL0137 in vivo was tested in a murine model of colorectal carcinogenesis induced by 1,2-dimethylhydrazine (DMH), which is known to involve WNT pathway dysregulation. After DMH subcutaneous treatment, mice were administered CBL0137 in drinking water. Efficacy of CBL0137 in suppressing development of colorectal cancer in this model was evidenced by reduced incidence of adenocarcinomas and adenomas in both males and females and decrease in tumor multiplicity. These data support the prospective use of CBL0137 in chemoprevention of colorectal cancer as well as of other malignances associated with activated WNT signaling.
Cloning and expression analysis of Serum Amyloid A (SAA) from Exopalaemon carinicauda (Holthuis, 1950) (Caridea, Palaemonidae)
Authors: Sun Shu Jie , Li Xue , Wang Chun Mei , Chen Jian Hua , Gao Huan , Yan Bin Lun 
Published: October 2019

Abstract
Serum amyloid A (SAA), an acute-phase protein, has been demonstrated to play a critical role in the inflammatory response. However, data regarding its function in crustaceans are still scarce. In the present study, cDNA of SAA from Exopalaemon carinicauda (Holthuis, 1950) (designated as EcSAA) was cloned and characterized. The full-length cDNA was 683 bp, including an open reading frame (ORF) of 267 bp that encoded 88 amino acid residues. The predicted amino acid sequence of EcSAA contained characteristic motifs of the SAA family. The EcSAA was widely expressed in all tissues, with the highest expression in gill and hepatopancreas. In response to the Vibrio anguillarum Bergeman, 1909 challenge, EcSAA mRNA was up-regulated in gill, hepatopancreas, and haemolymph. These results suggest thatEcSAA may be a constitutive and inducible acute-phase protein involved in anti-pathogen responses in E. carinicauda.
A Contested Field: Half a Century of Study of Second Temple Judaism
Authors: Collins John J. 
Published: October 2019

AbstractThere has been an explosion of interest in Second Temple Judaism over the last fifty years. In the first half of the period under review, the Pseudepigrapha were at the cutting edge. This period culminated in the publication of the new enlarged edition of the Old Testament Pseudepigrapha, edited by James H. Charlesworth. Beginning in the 1980s, interest shifted to the Dead Sea Scrolls, culminating in the rapid publication of the corpus under the editorship of Emanuel Tov. At the same time, new discoveries shed light on the encounter of Judaism with Hellenism, both in Judea in the Maccabean period and in the Egyptian diaspora. Few scholars would now defend an idea of “normative Judaism” in this period, but that idea still casts a shadow on the ongoing debates.
Assessing Postural Instability and Cybersickness Through Linear and Angular Displacement
Authors: Widdowson Christopher , Becerra Israel , Merrill Cameron , Wang Ranxiao Frances , LaValle Steven 
Published: October 2019

Objective To examine the hypothesis that constant speed is more comfortable than variable speed profiles and may minimize cybersickness. Background Current best practices for virtual reality (VR) content creation suggest keeping any form of acceleration as short and infrequent as possible to mitigate cybersickness. Methods In Experiment 1, participants experienced repetitions of simulated linear motion, and in Experiment 2, they experienced repetitions of a circular motion. Three speed profiles were tested in each experiment. Each trial lasted 2 min while standing. Cybersickness was measured using the Simulator Sickness Questionnaire (SSQ) and operationally defined in terms of total severity scores. Postural stability was measured using a Wii Balance Board and operationally defined in terms of center of pressure (COP) path length. Postural measures were decomposed into anterior-posterior and medial-lateral axes and subjected to detrended fluctuation analysis. Results For both experiments, no significant differences were observed between the three speed profiles in terms of cybersickness or postural stability, and none of the baseline postural measures could predict SSQ scores for the speed profile conditions. An axis effect was observed in both experiments such that normalized COP movement was significantly greater along the anterior-posterior axis than the medial-lateral axis. Conclusion Results showed no convincing evidence to support the common belief that constant speed is more comfortable than variable speed profiles for scenarios typical of VR applications. Application The present findings offer guidelines for the design of locomotion techniques involving traversal in VR environments.
Improvement of the Mouse Grimace Scale set-up for implementing a semi-automated Mouse Grimace Scale scoring (Part 1)
Authors: Ernst Lisa , Kopaczka Marcin , Schulz Mareike , Talbot Steven R , Zieglowski L , Meyer M , Bruch S , Merhof Dorit , Tolba Rene H 
Published: October 2019

The Mouse Grimace Scale (MGS) has been widely used for the noninvasive examination of distress/pain in mice. The aim of this study was to further improve its performance to generate repeatable, faster, blinded and reliable results for developing automated and standardized pictures for MGS scoring and simultaneous evaluation of up to four animals. Videos of seven C57BL/6N mice were generated in an experiment to assess pain and stress induced by repeated intraperitoneal injection of carbon tetrachloride (CCl4). MGS scores were taken 1 h before and after the injection. Videotaping was performed for 10 min in special observation boxes. For manual selection, pictures of each mouse were randomly chosen for quality analysis and scored according six quality selection criteria (0 = no, 1 = moderate, 2 = full accordance); the maximum possible score was 12. Overall, 609 pictures from six videos were evaluated for MGS scoring quality; evaluation was performed by using the picture selection tool or by manual scoring. With manual scoring, 288 pictures (48.3% of all randomly generated pictures) were deemed scorable using MGS (mean score = 22.15 ± SD 6.3). To evaluate the algorithm, ratings from different rater groups (beginner, medium-level trained, professional) were compared with the automated image generated. These differences were not significant ( p = 0.1091). This study demonstrates an improved set-up and a picture selection tool that can generate repeatable, not-observer biased and standardized pictures for MGS scoring.
A 3-Year Chronic Disease Public Health Intervention Focused on a Network of Rural Pharmacies Supported by Student Pharmacists
Authors: Nuffer Wesley , Gilliam Eric , Trujillo Tara , Griend Joseph Vande , Thompson Megan 
Published: October 2019

Objective: To retrospectively analyze and report various tracked outcomes of a 3-year collaboration offering chronic disease management services in diabetes and cardiovascular disease in pharmacies across 12 rural communities supported year-round by fourth-year student pharmacists. Methods: Individualized medication therapy management services were provided to patients with cardiovascular disease and diabetes in a 6-month series based upon national guidelines standards of care. Objective laboratory measurements, adherence rates, goals set for patients, vaccination rates, and routine maintenance examinations were all tracked as part of the program. Provider acceptance of recommendations from student pharmacists were tracked, and patients completed a 3-question survey regarding satisfaction with services. Results: A total of 430 student pharmacists rotated through these pharmacy sites providing care to 779 unique patients across 3 years. Statistically significant improvements in A1C (−0.8%, P < .001) and systolic and diastolic blood pressure (5 mm Hg, 3 mm Hg, respectively, P < .01) were associated with the pharmacy care. Adherence issues were identified and addressed with 44% of these patients. In all, 70% of patients reported successful goal attainment of >50% from baseline. Providers accepted student therapy change recommendations 56% of the time. Patients reported satisfaction with services provided in the pharmacies (average scores of 4.22-4.67 on a 1-5 Likert-type scale). Conclusions: A 3-year pharmacy intervention in 12 rural areas made positive impacts on patients’ adherence rates and self-management in diabetes and cardiovascular disease and was associated with statistically significant improvements in A1C and blood pressure while challenging fourth-year student pharmacists to perform at a high level on community pharmacy rotations.
Schneiderian Membrane Thickness Is Increased in Patients With Cleft Lip and Palate
Authors: Citron Isabelle , Lee Christine , Calabrese Carly E. , Padwa Bonnie L. 
Published: October 2019

Objective: Patients with cleft lip and palate (CLP) are more likely to have sinusitis. The purpose of this study is to determine whether patients with CLP have thickening of the Schneiderian membrane. Specific aims were to (1) compare Schneiderian membrane thickness in patients with CLP to noncleft controls, (2) evaluate whether membrane thickening is associated with cleft side in patients with unilateral cleft lip and palate (UCLP), and (3) evaluate if age and sex are predictors of mucosal thickening. Design: Case–control study. Setting: Tertiary care center. Patients: Patients with CLP and controls. Main Outcome Measure: The primary outcome variable was maximum Schneiderian membrane thickness measured on cone beam computed tomography. The primary predictor variable was the presence of a cleft. Additional variables were cleft phenotype, age, and sex. Results: There were 225 patients with CLP and 93 controls. Median mucosal thickness was 2.4 mm in cleft group and 0.0 mm in controls ( P = .006). In cleft group, 56.7% of sinuses had mucosal thickness >2.0 mm compared to 38.2% in controls ( P = < .004). Pathologic membrane thickening (>4.0 mm) was significantly higher in cleft group ( P = .005). No statistically significant difference in mucosal thickness between cleft and noncleft sides in patients with UCLP. Linear regression showed no association between age or sex and Schneiderian membrane thickness. Conclusion: Schneiderian membrane thickening is more common in patients with CLP and is not associated with the side of the cleft in patients with UCLP.
Serum 5-S-cysteinyl-dopa levels as a predictive marker for the efficacy of nivolumab in advanced malignant melanoma
Authors: Umemura Hiroshi , Kaji Tatsuya , Tachibana Kota , Morizane Shin , Yamasaki Osamu 
Published: October 2019

Purpose: With the recent developments in novel molecular targeted therapy such as immune-checkpoint blockades, serine/threonine-protein kinase B-Raf, and mitogen-activated protein kinase kinase inhibitors, the prognosis of advanced malignant melanoma has been improving. 5-S-cysteinyl-dopa (5-S-CD), a precursor of pheomelanin, has been previously revealed to be a useful biomarker for advanced-stage malignant melanoma, especially in patients with distant metastases. Here, we aimed to assess and compare the utility of serum 5-S-CD and lactate dehydrogenase levels as markers for predicting the effects of nivolumab in advanced malignant melanoma. Methods: Baseline serum 5-S-CD and lactate dehydrogenase levels in patients with unresectable stage IIIC and IV malignant melanoma treated with nivolumab ( n = 21) were analyzed to determine their utility as predictive markers for survival. We also analyzed the prognostic value of these markers among patients with only stage IV malignant melanoma ( n = 17). Results: Our analysis showed that patients with baseline serum 5-S-CD levels >25.0 nmol/L had significantly poor prognosis. In contrast, serum lactate dehydrogenase levels at the upper limit of the normal range did not exhibit such changes. Conclusions: Serum 5-S-CD levels have the potential to be an excellent predictive marker for the efficacy of nivolumab therapy in patients with advanced malignant melanoma.
Drainage Collection After Endoscopic-Assisted Transaxillary Dual-Plane Augmentation Mammaplasty Using Cold or Electrosurgical Separation of Interpectoral Space
Authors: Li Zifei , Mu Dali , Xu Boyang , Wang Chenglong , Cheng Hao , Li Shangshan , Qi Jun 
Published: October 2019

Background: Endoscopic transaxillary augmentation mammaplasty breast augmentation offers several advantages over other augmentation methods. Nonetheless, this procedure is fraught with some problems, including greater surgical trauma due to the longer separation area. We hypothesized that cold separation of the interpectoral space could reduce surgical injury in comparison to the electrosurgical method. This study aimed to compare the outcomes of endoscopic-assisted transaxillary augmentation mammaplasty using cold separation versus electrosurgical separation of the interpectoral space. Methods: In this prospective clinical trial, cold and electrosurgical separation of the interpectoral space were achieved using a separation shovel and monopolar electrotome, respectively. A total of 20 patients who visited our department in Beijing, China, for primary breast augmentation surgeries from October 1, 2017, and May 31, 2018, were included. The primary outcome was total postoperative drainage volume. The secondary outcomes were operative time, daily drainage volume, daily pain as assessed using the visual analogue scale (VAS), and reoperation rate. Quantitative data were compared using independent-samples t test. Chi-square test was used to compare 2 classified indexes. Results: The total drainage volume was significantly lower in the cold separation group than in the electrosurgical separation group (170.45 ± 75.40 mL vs 281.05 ± 148.43 mL; P = .005). The VAS score on the first postoperative day was significantly lower in the cold separation group than in the electrosurgical separation group (6.45 ± 1.93 vs 7.55 ± 1.43; P = .048). Two (20%) reoperations owing to postoperative pain or implant stiffness were performed in the electrosurgical separation group. Conclusions: Cold separation is more conducive to reducing drainage, relieving postoperative pain, and causing less damage than the electrosurgical method in endoscopic-assisted transaxillary dual-plane augmentation mammaplasty.
The Impact of Delaying Breast Reconstruction on Patient Expectations and Health-Related Quality of Life: An Analysis Using the BREAST-Q
Authors: Morzycki Alexander , Corkum Joseph , Joukhadar Nadim , Samargandi Osama , Williams Jason G. , Frank Simon G. 
Published: October 2019

Purpose: An understanding of patient expectations predicts better health outcomes following breast reconstruction. No study to date has examined how patient expectations for breast reconstruction and preoperative health-related quality of life vary with time since breast cancer diagnosis. Methods: Women consulting for breast reconstruction to a single surgeon’s practice over a 13-month period were enrolled in this cross-sectional study. Patients were asked to prospectively complete the BREAST-Q expectations and preoperative reconstruction modules. A retrospective chart review was then performed on eligible patients, and patient demographics, cancer-related factors, and comorbidities were collected. BREAST-Q scores were transformed using the equivalent Rasch method. Multivariate linear regression models were constructed to assess the association between BREAST-Q scores and time since cancer diagnosis. Results: Sixty-five patients met inclusion criteria for analysis and are characterized by a mean age of 53 ± 11 (34-79) years and a mean body mass index of 28 ± 6 (19-49). Most patients were treated by mastectomy (58%) or lumpectomy (23%). At the time of retrospective chart review, 29 (43%) patients had undergone reconstruction, most of which were delayed (59%). The mean latency from cancer diagnosis to reconstruction was 685 ± 867 days (range: 28-3322 days). Latency from cancer diagnosis to reconstruction was associated with a greater expectation of pain (β = 0.5; standard error [SE] = 0.005; 95% confidence interval [CI]: 0.003-0.027; P < .05), and a slower expectation for recovery (β = −0.5; SE = 0.004; 95% CI: −0.021 to −0.001; P < .05) after breast reconstruction. Latency from cancer diagnosis to reconstruction was associated with an increase in preoperative psychosocial well-being (β = 0.578; SE 0.009; 95% CI: 0.002-0.046; P < .05). Conclusion: Delaying breast reconstruction may negatively impact patient expectations of postoperative pain and recovery. Educational interventions aimed at understanding and managing patient expectations in the preoperative period may improve health-related quality of life and patient-related outcomes following initial breast cancer surgery.
Improved Morphological and Localized Surface Plasmon Resonance (LSPR) Properties of Fully Alloyed Bimetallic AgPt and Monometallic Pt NPs Via the One-Step Solid-State Dewetting (SSD) of the Ag/Pt Bilayers
Authors: Kunwar Sundar , Pandey Puran , Pandit Sanchaya , Sui Mao , Lee Jihoon 
Published: October 2019

Abstract
Multi-metallic alloy nanoparticles (NPs) can offer a promising route for the integration of multi-functional elements by the adaptation of advantageous individual NP properties and thus can exhibit the multi-functional dynamic properties arisen from the electronic heterogeneity as well as configurational diversity. The integration of Pt-based metallic alloy NPs are imperative in the catalytic, sensing, and energy applications; however, it usually suffers from the difficulty in the fabrication of morphologically well-structured and elementally well-alloyed NPs, which yields poor plasmonic responses. In this work, the improved morphological and localized surface plasmon resonance (LSPR) properties of fully alloyed bimetallic AgPt and monometallic Pt NPs are demonstrated on sapphire (0001) via the one-step solid-state dewetting (SSD) of the Ag/Pt bilayers. In a sharp contrast to the previous studies of pure Pt NPs, the surface morphology of the resulting AgPt and Pt NPs in this work are significantly improved such that they possess larger size, increased interparticle gaps, and improved uniformity. The intermixing of Ag and Pt atoms, AgPt alloy formation, and concurrent sublimation of Ag atoms plays the major roles in the fabrication of bimetallic AgPt and monometallic Pt NPs along with the enhanced global diffusion and energy minimization of NP system. The fabricated AgPt and Pt NPs show much-enhanced LSPR responses as compared to the pure Pt NPs in the previous studies, and the excitation of dipolar, quadrupolar, multipolar and higher-order resonance modes is realized depending upon the size, configuration, and elemental compositions. The LSPR peaks demonstrate drastic alteration along with the evolution of AgPt and Pt NPs, i.e., the resonance peaks are shifted and enhanced by the variation of size and Ag content.
Genome-wide characterization of NtHD-ZIP IV: different roles in abiotic stress response and glandular Trichome induction
Authors: Zhang Hongying , Ma Xudong , Li Wenjiao , Niu Dexin , Wang Zhaojun , Yan Xiaoxiao , Yang Xinling , Yang Yongfeng , Cui Hong 
Published: October 2019

AbstractBackgroundThe plant-specific homeodomain-leucine zipper class IV (HD-ZIP IV) gene family has been involved in the regulation of epidermal development.ResultsFifteen genes coding for HD-ZIP IV proteins were identified (NtHD-ZIP-IV-1toNtHD-ZIP-IV-15) based on the genome ofN. tabacum. Four major domains (HD, ZIP, SAD and START) were present in these proteins. Tissue expression pattern analysis indicated thatNtHD-ZIP-IV-1, − 2,− 3,− 10, and − 12may be associated with trichome development;NtHD-ZIP-IV-8was expressed only in cotyledons;NtHD-ZIP-IV-9only in the leaf and stem epidermis;NtHD-ZIP-IV-11only in leaves; andNtHD-ZIP-IV-15only in the root and stem epidermis. We found that jasmonates may induce the generation of glandular trichomes, and thatNtHD-ZIP-IV-1, − 2, − 5,and − 7were response to MeJA treatment. Dynamic expression under abiotic stress and after application of phytohormones indicated that mostNtHD-ZIP IVgenes were induced by heat, cold, salt and drought. Furthermore, most of these genes were induced by gibberellic acid, 6-benzylaminopurine, and salicylic acid, but were inhibited by abscisic acid.NtHD-ZIP IVgenes were sensitive to heat, but insensitive to osmotic stress.ConclusionNtHD-ZIP IVgenes are implicated in a complex regulatory gene network controlling epidermal development and abiotic stress responses. The present study provides evidence to elucidate the gene functions ofNtHD-ZIP IVs during epidermal development and stress response.