bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revealing the cosmic evolution of boxy/peanut-shaped bulges from HST COSMOS and SDSS
Authors: Kruk Sandor J , Erwin Peter , Debattista Victor P , Lintott Chris 
Published: October 2019

ABSTRACT
Vertically thickened bars, observed in the form of boxy/peanut (B/P) bulges, are found in the majority of massive barred disc galaxies in the local Universe, including our own. B/P bulges indicate that their host bars have suffered violent bending instabilities driven by anisotropic velocity distributions. We investigate for the first time how the frequency of B/P bulges in barred galaxies evolves from z = 1 to z ≈ 0, using a large sample of non-edge-on galaxies with masses M⋆ > 1010 M⊙, selected from the HST COSMOS survey. We find the observed fraction increases from $0^{+3.6}_{-0.0}{{\ \rm per\ cent}}$ at z = 1 to $37.8^{+5.4}_{-5.1}$ per cent at z = 0.2. We account for problems identifying B/P bulges in galaxies with low inclinations and unfavourable bar orientations, and due to redshift-dependent observational biases with the help of a sample from the Sloan Digital Sky Survey, matched in resolution, rest-frame band, signal-to-noise ratio and stellar mass and analysed in the same fashion. From this, we estimate that the true fraction of barred galaxies with B/P bulges increases from ∼10 per cent at z ≈ 1 to $\sim 70{{\ \rm per\ cent}}$ at z = 0. In agreement with previous results for nearby galaxies, we find a strong dependence of the presence of a B/P bulge on galaxy stellar mass. This trend is observed in both local and high-redshift galaxies, indicating that it is an important indicator of vertical instabilities across a large fraction of the age of the Universe. We propose that galaxy formation processes regulate the thickness of galaxy discs, which in turn affect which galaxies experience violent bending instabilities of the bar.
Angular momentum and heat transport on tidally locked hot Jupiter planets
Authors: Mendonça João M 
Published: October 2019

ABSTRACT
The atmospheric circulation in the upper atmosphere of hot Jupiter planets is strongly influenced by the incoming stellar radiation. In this work, we explore the results from a 3D atmospheric model and revisit the main processes driving the circulation in hot Jupiter planets. We use the angular momentum transport as a diagnostic and carry out a Fourier analysis to identify the atmospheric waves involved. We find that the coupling between the angular momentum transported horizontally by the semidiurnal tide and the mean circulation is the mechanism responsible for producing the strong jet at low latitudes. Our simulations indicate the possible formation of atmospheric indirect cells at low latitudes. The formation of these cells is induced by the presence of the semidiurnal tide that is driven by the stellar irradiation. The tropical circulation has an important impact transporting heat and momentum from the upper towards the lower atmosphere. One of the consequences of this heat and momentum transport is a global increase of the temperature. We show that the initial conditions do not affect the output of the reference simulation. However, when the period of rotation of the planet was increased (Prot > 5 Earth days), vertical transport by stationary waves became stronger, transient waves became non-negligible, and Coriolis influence less dominant, which allowed a steady state with a strong retrograde jet to be stable. We found that at least two statically steady state solutions exist for the same planet parameters.
Automated wind velocity profiling from adaptive optics telemetry
Authors: Laidlaw Douglas J , Osborn James , Morris Timothy J , Basden Alastair G , Gendron Eric , Rousset Gérard , Townson Matthew J , Wilson Richard W 
Published: October 2019

Abstract
Ground-based adaptive optics (AO) systems can use temporal control techniques to greatly improve image resolution. A measure of wind velocity as a function of altitude is needed to minimize the temporal errors associated with these systems. Spatio-temporal analysis of AO telemetry can express the wind velocity profile using the SLODAR technique. However, the limited altitude-resolution of current AO systems makes it difficult to disentangle the movement of independent layers. It is therefore a challenge to create an algorithm that can recover the wind velocity profile through SLODAR data analysis. In this study we introduce a novel technique for automated wind velocity profiling from AO telemetry. Simulated and on-sky centroid data from CANARY - an AO testbed on the 4.2 m William Herschel telescope, La Palma - is used to demonstrate the proficiency of the technique. Wind velocity profiles measured on-sky are compared to contemporaneous measurements from Stereo-SCIDAR, a dedicated high-resolution atmospheric profiler. They are also compared to European centre for medium-range weather forecasts. The software package that we developed to complete this study is open source.
Obscuration properties of mid-IR-selected AGN
Authors: Mountrichas G , Georgantopoulos I , Ruiz A , Kampylis G 
Published: October 2019

ABSTRACT
The goal of this work is to study the obscuration properties of mid-infrared (mid-IR)-selected active galactic nuclei (AGN). For that purpose, we use Wide-field Infrared Survey Explorer (WISE) sources in the Stripe 82–XMM area to identify mid-IR AGN candidates, applying the Assef et al. criteria. Stripe 82 has optical photometry ≈2 times deeper than any single-epoch Sloan Digital Sky Survey (SDSS) region. XMM–Newton observations cover ∼26 deg2. Applying the aforementioned criteria, 1946 IR AGN are selected. ${\sim} 78{{\, \rm per\, cent}}$ have SDSS detection, while 1/3 of them are detected in X-rays, at a flux limit of $\rm {\sim} 5 \times 10^{-15}\, erg\, s^{-1}\, cm^{-2}$. Our final sample consists of 507 IR AGN with X-ray detection and optical spectra. Applying a $r-W2 &gt; 6$ colour criterion, we find that the fraction of optically red AGN drop from 43 per cent for those sources with SDSS detection to $23{{\, \rm per\, cent}}$ for sources that also have X-ray detection. X-ray spectral fitting reveals 40 (${\sim} 8{{\, \rm per\, cent}}$) X-ray absorbed AGN ($N_\mathrm{ H} &gt; 10^{22}\,{\rm cm}^{-2}$). Among the X-ray unabsorbed AGN, there are 70 red systems. To further investigate the absorption of these sources, we construct spectral energy distributions (SEDs) for the total IR AGN sample. SED fitting reveals that ${\sim} 20{{\, \rm per\, cent}}$ of the optically red sources have such colours because the galaxy emission is a primary component in the optical part of the SED, even though the AGN emission is not absorbed at these wavelengths. SED fitting also confirms that $12{{\, \rm per\, cent}}$ of the X-ray unabsorbed IR AGN are optically obscured.
Mitochondrial Metagenomics Reveals the Ancient Origin and Phylodiversity of Soil Mites and Provides a Phylogeny of the Acari
Authors: Arribas Paula , Andújar Carmelo , Moraza María Lourdes , Linard Benjamin , Emerson Brent C , Vogler Alfried P 
Published: October 2019

Abstract
High-throughput DNA methods hold great promise for phylogenetic analysis of lineages that are difficult to study with conventional molecular and morphological approaches. The mites (Acari), and in particular the highly diverse soil-dwelling lineages, are among the least known branches of the metazoan Tree-of-Life. We extracted numerous minute mites from soils in an area of mixed forest and grassland in southern Iberia. Selected specimens representing the full morphological diversity were shotgun sequenced in bulk, followed by genome assembly of short reads from the mixture, which produced &gt;100 mitochondrial genomes representing diverse acarine lineages. Phylogenetic analyses in combination with taxonomically limited mitogenomes available publicly resulted in plausible trees defining basal relationships of the Acari. Several critical nodes were supported by ancestral-state reconstructions of mitochondrial gene rearrangements. Molecular calibration placed the minimum age for the common ancestor of the superorder Acariformes, which includes most soil-dwelling mites, to the Cambrian–Ordovician (likely within 455–552 Ma), whereas the origin of the superorder Parasitiformes was placed later in the Carboniferous-Permian. Most family-level taxa within the Acariformes were dated to the Jurassic and Triassic. The ancient origin of Acariformes and the early diversification of major extant lineages linked to the soil are consistent with a pioneering role for mites in building the earliest terrestrial ecosystems.
Return to Work Following Surgery for Incidental Diffuse Low-Grade Glioma: A Prospective Series With 74 Patients
Authors: Ng Sam , Herbet Guillaume , Moritz-Gasser Sylvie , Duffau Hugues 
Published: October 2019

Abstract

BACKGROUND
Therapeutic strategy concerning incidental low-grade glioma (ILGG) is still debated. Early “prophylactic” surgery has been proposed in asymptomatic patients with favorable neurological and oncological outcomes.

OBJECTIVE
To assess postoperative ability to resume employment following awake surgery in asymptomatic ILGG patients. To assess extent of resection (EOR), timeline for adjuvant oncological treatment, and survival.

METHODS
A total of 74 patients with ILGG who underwent awake surgery with intraoperative mapping were prospectively included, with a minimum follow-up of 12 mo. All clinicoradiological data were collected, and statistical correlations with return to work (RTW) were performed.

RESULTS
A total of 66 patients (97.1%) among 68 patients with preoperative professional activities resumed their employment including 62 (91.2%) within 12 mo. Mean time before RTW was 6.8 mo (median: 6 mo, range: 1-36). Two patients experienced seizure-related legal issues impacting their RTW. Clinicoradiological features did not correlate with RTW apart from postoperative seizures (P = .02). Mean EOR was 95.7%. A total of 43 patients (58.1%) underwent supratotal/total resections. All patients recovered from transient deficits at 3 mo. No patients received consecutive adjuvant treatment. A total of 24 patients (32.4%) were reoperated, 24 patients received chemotherapy, and 7 patients (9.5%) received radiotherapy, on average 73.1 mo after surgery. Mean follow-up was 67 mo (range 12-240). Four patients (5.4%) died during the follow-up.

CONCLUSION
We observed a high rate of RTW (97.1%, including 91.2% within 12 mo) after awake surgery in ILGG patients. Delayed resumption of work was due to employer not clearing them for RTW, personal choice, and, in rare occasions, related to seizures.
Blood Pressure Variability and Optimal Cerebral Perfusion Pressure—New Therapeutic Targets in Traumatic Brain Injury
Authors: Svedung Wettervik Teodor , Howells Timothy , Lewén Anders , Enblad Per 
Published: October 2019

Abstract

BACKGROUND
Optimal cerebral perfusion pressure (CPPopt) is an autoregulatory-oriented target in the neurointensive care (NIC) of patients with traumatic brain injury (TBI), and deviation from CPPopt is associated with poor outcome. We recently found that blood pressure variability (BPV) is associated with deviation from CPPopt.

OBJECTIVE
To evaluate BPV and other variables related to deviation from CPPopt and to evaluate challenges and strategies for autoregulatory-oriented treatment in TBI.

METHODS
Data including arterial blood pressure and intracranial pressure (ICP) from 362 TBI patients treated at the NIC unit, Uppsala University Hospital, Sweden, between 2008 and 2016, were retrospectively analyzed day 2 to 5.

RESULTS
Higher BPV was a strong predictor of both CPP deviation below and above CPPopt after multiple regression analyses. There was no other explanatory variable for CPP deviation above CPPopt, whereas also higher ICP and worse autoregulation (higher pressure reactivity index) were associated with CPP deviation below CPPopt. A higher BPV was, in turn, explained by older age, lower ICP, higher mean arterial blood pressure, and higher slow arterial blood pressure amplitude (0.018-0.067 Hz).

CONCLUSION
BPV was strongly associated with deviation from CPPopt. High age is a risk factor for high BPV and hence CPP insults. Our treatment protocol is focused on avoiding CPP below 60 mm Hg. It is possible that a more restrictive upper level could generate more stable blood pressure and less deviation from CPPopt.
Brain tumors in neurofibromatosis type 1
Authors: Costa Amanda De Andrade , Gutmann David H 
Published: October 2019

AbstractAbstractAs a cancer predisposition syndrome, individuals with neurofibromatosis type 1 (NF1) are at increased risk for the development of both benign and malignant tumors. One of the most common locations for these cancers is the central nervous system, where low-grade gliomas predominate in children. During early childhood, gliomas affecting the optic pathway are most frequently encountered, whereas gliomas of the brainstem and other locations are observed in slightly older children. In contrast, the majority of gliomas arising in adults with NF1 are malignant cancers, typically glioblastoma, involving the cerebral hemispheres. Our understanding of the pathogenesis of NF1-associated gliomas has been significantly advanced through the use of genetically engineered mice, yielding new targets for therapeutic drug design and evaluation. In addition, Nf1 murine glioma models have served as instructive platforms for defining the cell of origin of these tumors, elucidating the critical role of the tumor microenvironment in determining tumor growth and vision loss, and determining how cancer risk factors (sex, germline NF1 mutation) impact on glioma formation and progression. Moreover, these preclinical models have permitted early phase analysis of promising drugs that reduce tumor growth and attenuate vision loss, as an initial step prior to translation to human clinical trials.
Evidence-based policy analysis? The strange case of the randomized controlled trials of community-led total sanitation
Authors: Whittington Dale , Radin Mark , Jeuland Marc 
Published: October 2019

AbstractOur purpose in this paper is to review the findings of 14 randomized controlled trials (RCTs) of community-led total sanitation (CLTS) and recent rural sanitation interventions to assess their usefulness and implications for sanitation policy-making in low- and middle-income countries. The results of the RCT research programme to evaluate CLTS and related sanitation interventions suggest that the magnitude of the treatment effects was much smaller and uncertain than proponents once anticipated. For example, of the ten studies that reported results for reductions in childhood diarrhoea, only three found statistically significant decreases. Surprisingly, the RCT research teams and their funders do not seem to have thought about how their multi-million dollar research agenda would support decision-making on sanitation. Information on the parameters needed for cost-effectiveness analysis or benefit–cost analysis was not collected. However, making reasonable assumptions about the missing information on parameter values, we show that cost–benefit analysis may still ‘save’ CLTS because small treatment effects may still yield net positive economic benefits if the costs of implementing CLTS programmes are modest. We also discuss the need to move beyond the desire for sanitation policies that are proven to be effective globally, and the importance of focusing on analysis of the local sanitation situation. We describe the data needed to make this shift in policy focus from the global to the local level and stress the importance of interdisciplinary communication between the proponents of RCTs and ‘evidence-based policy’, and economists who will be responsible for the economic analysis of investments in CLTS and other sanitation interventions. We also argue that the results of these RCTs highlight the importance of coordinating investments in piped water and sanitation with investments in improved housing.
Genetic and epidemiological characterization of restless legs syndrome in Québec
Authors: Akçimen Fulya , Ross Jay P , Sarayloo Faezeh , Liao Calwing , De Barros Oliveira Rachel , Ruskey Jennifer A , Bourassa Cynthia V , Dion Patrick A , Xiong Lan , Gan-Or Ziv , Rouleau Guy A 
Published: October 2019

Abstract
Currently, a total of 19 genetic loci are associated with the risk for developing RLS. This study aimed to assess these RLS predisposing genetic variants, as well as investigate the epidemiological profile and diagnostic features of individuals with RLS in the Québec population, using an interviewer–administered questionnaire. A total of 18 RLS-associated variants were genotyped in the Québec population-based CARTaGENE cohort. A case–control series consisting of 1,362 RLS cases and 1,379 age-matched unaffected controls was used to conduct a genetic and epidemiological association study that integrated the first four RLS diagnostic features of affected individuals, as well as additional RLS-related questions (e.g. frequency of the symptoms and number of total pregnancies in female). Five RLS-predisposing variants were significantly associated after Bonferroni correction and an additional five variants were nominally associated with RLS (p &lt; 0.05). BTBD9 was the strongest genetic risk factor in our cohort (rs9296249, OR = 1.71, p = 9.57 × 10−10). The patient group that met all four essential diagnostic criteria of RLS provided the most significant genetic findings. These results suggest that employing the questionnaire which included standard diagnostic criteria of RLS could improve the accuracy of the survey-based studies.
Highly multiplexed, fast and accurate nanopore sequencing for verification of synthetic DNA constructs and sequence libraries
Authors: Currin Andrew , Swainston Neil , Dunstan Mark S , Jervis Adrian J , Mulherin Paul , Robinson Christopher J , Taylor Sandra , Carbonell Pablo , Hollywood Katherine A , Yan Cunyu , Takano Eriko , Scrutton Nigel S , Breitling Rainer 
Published: October 2019

Abstract
Synthetic biology utilizes the Design–Build–Test–Learn pipeline for the engineering of biological systems. Typically, this requires the construction of specifically designed, large and complex DNA assemblies. The availability of cheap DNA synthesis and automation enables high-throughput assembly approaches, which generates a heavy demand for DNA sequencing to verify correctly assembled constructs. Next-generation sequencing is ideally positioned to perform this task, however with expensive hardware costs and bespoke data analysis requirements few laboratories utilize this technology in-house. Here a workflow for highly multiplexed sequencing is presented, capable of fast and accurate sequence verification of DNA assemblies using nanopore technology. A novel sample barcoding system using polymerase chain reaction is introduced, and sequencing data are analyzed through a bespoke analysis algorithm. Crucially, this algorithm overcomes the problem of high-error rate nanopore data (which typically prevents identification of single nucleotide variants) through statistical analysis of strand bias, permitting accurate sequence analysis with single-base resolution. As an example, 576 constructs (6 × 96 well plates) were processed in a single workflow in 72 h (from Escherichia coli colonies to analyzed data). Given our procedure’s low hardware costs and highly multiplexed capability, this provides cost-effective access to powerful DNA sequencing for any laboratory, with applications beyond synthetic biology including directed evolution, single nucleotide polymorphism analysis and gene synthesis.
Temporomandibular Joint Herniation: Review of the Literature
Authors: Jo Yong Seok , Cheong Taek Yoon , Han Byung Hyun , Lee Jeon Mi , Kim Sung Huhn , Moon In Seok 
Published: October 2019

Objective:
To define clear clinical characteristics and management strategies of herniation of temporomandibular joint (TMJ) into the external auditory canal (EAC).

Data Source:
MEDLINE, PubMed, and EMBASE databases.

Study Selection:
A search was conducted using the keywords “temporomandibular joint” and “herniation” with all of their synonyms. Literature selection criteria included articles published in English, and articles dating back no further than 1970.

Results:
Forty articles regarding 51 cases were eligible for critical appraisal. According to the previously published papers, TMJ herniation has following characteristics; symptoms are nonspecific, but a distinguishable feature is a protruding mass into the EAC that can be seen to appear and disappear as the mouth opens and closes. High-resolution computed tomography scans are sensitive to the bony defect and are helpful in diagnosing TMJ herniation. In the surgical treatment of TMJ herniation, wall reconstruction rather than simple mass excision could be a safe and long-lasting strategy.

Conclusions:
Herniation of TMJ into the EAC is a rare condition, but can be encountered in the clinic at any time. This literature review could be helpful in the diagnosis and treatment of TMJ herniation into the EAC.
The Veterans Affairs Continuous Positive Airway Pressure Use and Diabetic Retinopathy Study
Authors: Smith James Patrick , Cyr Luke G. , Dowd Laura K. , Duchin Kyla S. , Lenihan Priscilla A. , Sprague Jennifer 
Published: October 2019

SIGNIFICANCE
Obstructive sleep apnea has been linked to the development and progression of diabetic retinopathy. In this study, diabetic patients compliant with continuous positive airway pressure therapy (CPAP) for sleep apnea were less likely to have retinopathy, emphasizing the benefits and potential therapeutic role of CPAP in individuals with both conditions.

PURPOSE
The aim of this study was to compare the prevalence of diabetic retinopathy in type 2 diabetic patients with obstructive sleep apnea who were compliant with CPAP therapy with those who were not compliant with CPAP therapy.

METHODS
A retrospective cross-sectional review of type 2 diabetic patients using CPAP for obstructive sleep apnea was conducted. The prevalence of retinopathy was identified, and groups with and without retinopathy were compared using univariate analyses and multivariate logistic regression.

RESULTS
The prevalence of retinopathy was 19.6% (n = 321). Retinopathy was significantly less prevalent in those compliant with CPAP (odds ratio, 0.54; 95% confidence interval, 0.31 to 0.94; P = .04). The relationship remained statistically significant when adjusting for other factors known to impact the course of diabetic eye disease.

CONCLUSIONS
Increased CPAP compliance may mitigate the risk of developing diabetic retinopathy in type 2 diabetic patients with obstructive sleep apnea.
A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation
Authors: Tsuboyama Kotaro , Osaki Tatsuya , Suzuki-Matsuura Eriko , Kozuka-Hata Hiroko , Okada Yuki , Oyama Masaaki , Ikeuchi Yoshiho , Iwasaki Shintaro , Tomari Yukihide 
Published: October 2019

AbstractProteins are typically denatured and aggregated by heat. Exceptions to this principle include highly disordered and heat-resistant proteins found in extremophiles, which help these organisms tolerate extreme conditions such as drying, freezing, and high salinity. In contrast, the functions of heat-soluble proteins in non-extremophilic organisms including humans remain largely unexplored. Here we report that heat-resistant obscure (Hero) proteins, which remain soluble after boiling at 95°C, are widespread in Drosophila and humans. Hero proteins are hydrophilic and highly charged, and function to stabilize various “client” proteins, protecting them from denaturation even under stress conditions such as heat shock, desiccation, and exposure to organic solvents. Hero proteins can also block several different types of pathological protein aggregations in cells and in Drosophila strains that model neurodegenerative diseases. Moreover, Hero proteins can extend lifespan of Drosophila. Our study reveals that organisms naturally use Hero proteins as molecular shields to stabilize protein functions, highlighting their biotechnological and therapeutic potential.