bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benefits of using the Brief Pain Inventory in patients with cancer pain: an intervention study conducted in Swedish hospitals
Authors: Andersson Viveka , Bergman Stefan , Henoch Ingela , Simonsson Hanna , Ahlberg Karin 
Published: December 2019

Abstract
Purpose
The prevalence of cancer pain is too high. There is a need for improvement of pain management in cancer care. The aim of this study was to explore whether the use of the multidimensional pain assessment questionnaire Brief Pain Inventory (BPI) could improve pain relief in hospitalized patients with cancer.

Methods
A controlled intervention study was performed at two hospitals in western Sweden, 264 patients were included, 132 formed a control group and 132 an intervention group. All participants completed the BPI and the Edmonton Symptom Assessment Scale (ESAS) at baseline. Only the researcher had access to questionnaires from the control group. The completed forms from the intervention group were presented to the patients’ care team. A follow-up took place after 2–5 days when patients in both groups rated the scales a second time.

Results
In the intervention group, significant differences in all measured items of the BPI were found at follow-up compared with baseline. Symptoms rated with the ESAS also decreased significantly, except shortness of breath. At follow-up, a significant increase in regular use of paracetamol, anti-neuropathic pain drugs and opioids was found, as well as elevated doses of fixed-schedule opioids. In the control group, differences between baseline and follow-up were significant regarding average pain and worst pain over the past 24 h.

Conclusion
Presenting the patient-reported BPI to the care team helped them to focus on patients’ pain, identify pain mechanisms and adjust analgesics accordingly. A possible explanation for the results is changes in the medication prescribed.
Spectroscopic and biochemical insight into an electron-bifurcating [FeFe] hydrogenase
Authors: Chongdar Nipa , Pawlak Krzysztof , Rüdiger Olaf , Reijerse Edward J. , Rodríguez-Maciá Patricia , Lubitz Wolfgang , Birrell James A. , Ogata Hideaki 
Published: December 2019

AbstractThe heterotrimeric electron-bifurcating [FeFe] hydrogenase (HydABC) fromThermotoga maritima(Tm) couples the endergonic reduction of protons (H+) by dihydronicotinamide adenine dinucleotide (NADH) (∆G0 ≈ 18 kJ mol−1) to the exergonic reduction of H+by reduced ferredoxin (Fdred) (∆G0 ≈ − 16 kJ mol−1). The specific mechanism by which HydABC functions is not understood. In the current study, we describe the biochemical and spectroscopic characterization ofTmHydABC recombinantly produced inEscherichia coliand artificially maturated with a synthetic diiron cofactor. We found thatTmHydABC catalyzed the hydrogen (H2)-dependent reduction of nicotinamide adenine dinucleotide (NAD+) in the presence of oxidized ferredoxin (Fdox) at a rate of  ≈17 μmol NADH min−1 mg−1. Our data suggest that only one flavin is present in the enzyme and is not likely to be the site of electron bifurcation. FTIR and EPR spectroscopy, as well as FTIR spectroelectrochemistry, demonstrated that the active site for H2conversion, the H-cluster, inTmHydABC behaves essentially the same as in prototypical [FeFe] hydrogenases, and is most likely also not the site of electron bifurcation. The implications of these results are discussed with respect to the current hypotheses on the electron bifurcation mechanism of [FeFe] hydrogenases. Overall, the results provide insight into the electron-bifurcating mechanism and present a well-defined system for further investigations of this fascinating class of [FeFe] hydrogenases.Graphic abstract
Phase I study of TAS-115, a novel oral multi-kinase inhibitor, in patients with advanced solid tumors
Authors: Doi Toshihiko , Matsubara Nobuaki , Kawai Akira , Naka Norifumi , Takahashi Shunji , Uemura Hiroji , Yamamoto Noboru 
Published: December 2019

SummaryTAS-115 is a novel MET, VEGFR, FMS and PDGFR inhibitor, developed to improve the continuity of drug administration with a relatively short half-life. We assessed its tolerability, safety, pharmacokinetics, efficacy, and pharmacodynamics in patients with solid tumors. This open-label, dose-escalation phase I study of TAS-115 consisted of three parts: part 1 (TAS-115 was administered orally once daily [SID]); part 2 and an expansion part (SID in a 5 days on/2 days off [5-on/2-off] schedule for 21 days per cycle). In part 1 (200–800 mg SID administered to 21 patients), systemic exposure after single administration increased almost dose-proportionally. Three dose-limiting toxicities (DLTs) were observed in three patients: grade 3 rash (650 mg), thrombocytopenia with bleeding, and rash (800 mg). The maximum tolerated dose (MTD) was determined as 650 mg SID. In part 2, the 5-on/2-off schedule was evaluated at the MTD to improve treatment exposure. No DLTs were observed and no patients required treatment interruption in cycle 1. During part 2 and the expansion part (N = 61), grade ≥3 treatment-related adverse events were reported in 47 patients, with neutropenia (24.6%), hypophosphatemia (21.3%), anemia, and thrombocytopenia (14.8% each), and leukocytopenia (11.5%) occurring in ≥10% of patients. The best overall response was stable disease in 31 of 82 patients (37.8%). An apparent reduction in fluorodesoxyglucose-uptake and bone scan index was observed in some patients. TAS-115 was generally well tolerated, with manageable toxicities and recommended phase II dose was estimated as 650 mg SID, 5-on/2-off. Furthermore, promising antitumor activity was observed.
Early years teachers and digital literacies: Navigating a kaleidoscope of discourses
Authors: Daniels Karen , Bower Kim , Burnett Cathy , Escott Hugh , Hatton Amanda , Ehiyazaryan-White Ester , Monkhouse Jemma 
Published: December 2019

AbstractFor many young children in developed countries, family and community life is mediated by digital technology. Despite this, for early years educators, the process of integrating digital technologies into classroom practice raises a number of issues and tensions. In an attempt to gain insights from early years teachers, we draw from semi-structured interview data from ten practising teachers which explored their perspectives on digital technologies within their personal and professional lives, and of children’s use of digital technologies within and outside educational settings. Our analysis builds on previous work that suggests that teachers draw on multiple discourses related to conceptualisations of childhood when thinking about digital technology and young children. In this paper we contribute to these discussions, drawing specifically on examples from the data where teachers articulate their understandings of children’s use of digital technology where this relates directly to children’s literacy practices. We assert that narrow conceptualized notions of literacy, compounded by national imperatives to raise print literacy standards, add another layer of discursive complexity that comes to the fore when teachers are asked to provide a rationale for the promotion of digital literacies in early years classrooms. A broader framing of literacy therefore, is needed if the potential of digital technologies in the early years is to be realized.
QTL analysis for rice salinity tolerance and fine mapping of a candidate locus qSL7 for shoot length under salt stress
Authors: Jahan Noushin , Zhang Yu , Lv Yang , Song Mengqiu , Zhao Chunyan , Hu Haitao , Cui Yongtao , Wang Zhongwei , Yang Shenglong , Zhang Anpeng , Hu Jiang , Ye Guoyou , Qian Qian , Gao Zhenyu , Guo Longbiao 
Published: December 2019

AbstractSalinity is one of the major abiotic stresses limiting rice production worldwide. Understanding the genetic basis of salinity tolerance is key for rice breeding. In this study, a recombinant inbred line (RIL) population derived from a super hybrid rice Liang–You–Pei–Jiu (LYP9) parents 93-11 and PA64s, exhibited variation in phenotypes including shoot length (SL), root length (RL), shoot fresh weight (SFW), root fresh weight (RFW), shoot dry weight (SDW), and root dry weight (RDW) under 50 and 100 mM NaCl stress. QTL analysis identified a total of 38 QTLs for these 6 traits under two distinct concentrations of salt, distributing on chromosomes 1, 2, 3, 4, 5, 6, 7 and 10. A total of 21 QTLs were found in 6 stable loci. A novel major QTL, qSL7 for shoot length on chromosome 7 was identified in two distinct concentrations. A chromosome segment substitution line (CSSL) harboring the qSL7 locus from PA64s with 93-11 background was developed and exhibited higher SL value, higher K+ concentration, and lower Na+ concentration compared to 93-11. With BC5F2:3 derived from CSSL-qSL7/93-11, the qSL7 was fine mapped within a 252.9 kb region on chromosome 7 where 40 annotated genes located including, LOC_Os07g43530, which encodes a DNA-binding domain containing protein reported previously as a transcription factor playing a positive role in salt stress tolerance. Our study provides new genetic resources for improvement of salinity tolerance in rice breeding.
The insider view: tackling disabling practices in higher education institutions
Authors: Merchant Wendy , Read Stuart , D’Evelyn Stephen , Miles Caroline , Williams Val 
Published: December 2019

AbstractThis paper reports on research about the experiences of disabled staff members in UK universities, drawing on eleven semi-structured interviews with disabled staff in one university, alongside a group auto ethnography conducted by the first four authors, all of whom identified as disabled academics. Disability is generally considered to be predominantly an issue for students, both in practice and in the literature. By contrast, taking a social practice approach, we focused on the barriers faced by disabled employees, both overt and hidden. We found that disability was still viewed as a medical problem, and that disabled members of staff faced considerable extra labour in organising their own supports. We were often made to feel that we were unwanted and that we were ‘misfits’ in the institution. This paper contributes to theory by showing how social practices can become exclusionary, and how interconnections between practices matter. We discuss ways in which ableism, based on the ideal of ‘individual’ excellence, creates barriers for disabled staff. In the global context of Higher Education, the increasing marketization of universities in higher income countries creates a difficult climate for the values of inclusion.
Cercopithecine and Colobine Abundance Across Protected and Unprotected Land in the Greater Mahale Ecosystem, Western Tanzania
Authors: McLester Edward , Pintea Lilian , Stewart Fiona A. , Piel Alex K. 
Published: December 2019

AbstractMost primates live in unprotected land where abundances and threats may differ from those in protected areas. We therefore need to establish population densities in both unprotected and protected areas to effectively inform conservation planning. The Greater Mahale Ecosystem in western Tanzania is a region of mixed protected status with seven cercopithecine and colobine species: blue (Cercopithecus mitis doggetti), red-tailed (C. ascanius schmidi), and vervet (Chlorocebus pygerythrus) monkeys; ashy red colobus (Piliocolobus tephrosceles); black-and-white colobus (Colobus angolensis); and olive (Papio anubis) and yellow (P. cynocephalus) baboons. These species may be threatened by increasing human activity; however, except for ashy red colobus, no data on local abundances are available. We walked over 350 km of line transects in legally protected (Village Forest Reserves) and unprotected general land between August 2011 and October 2012 to estimate densities of primates and human activity. Primate densities were consistently low across the Greater Mahale Ecosystem. Blue and red-tailed monkey and ashy red colobus densities were especially low compared to populations in predominantly forested landscapes. Primate and human activity densities did not differ significantly inside and outside of reserves. Low primate densities could be natural responses to the lower proportions and quality of riparian forest habitat in the region. High levels of human activity and the absence of significantly higher primate densities in reserves suggest unprotected land could provide important refuges for primates in the Greater Mahale Ecosystem. This result further reinforces a broad need to include unprotected areas in primate conservation strategies.
A Relaxation of Üresin and Dubois’ Asynchronous Fixed-Point Theory in Agda
Authors: Daggitt Matthew L. , Zmigrod Ran , Griffin Timothy G. 
Published: December 2019

AbstractÜresin and Dubois’ paper “Parallel Asynchronous Algorithms for Discrete Data” shows how a class of synchronous iterative algorithms may be transformed into asynchronous iterative algorithms. They then prove that the correctness of the resulting asynchronous algorithm can be guaranteed by reasoning about the synchronous algorithm alone. These results have been used to prove the correctness of various distributed algorithms, including in the fields of routing, numerical analysis and peer-to-peer protocols. In this paper we demonstrate several ways in which the assumptions that underlie this theory may be relaxed. Amongst others, we (i) expand the set of schedules for which the asynchronous iterative algorithm is known to converge and (ii) weaken the conditions that users must prove to hold to guarantee convergence. Furthermore, we demonstrate that two of the auxiliary results in the original paper are incorrect, and explicitly construct a counter-example. Finally, we also relax the alternative convergence conditions proposed by Gurney based on ultrametrics. Many of these relaxations and errors were uncovered after formalising the work in the proof assistant Agda. This paper describes the Agda code and the library that has resulted from this work. It is hoped that the library will be of use to others wishing to formally verify the correctness of asynchronous iterative algorithms.
Multimodal Imaging Techniques Show Differences in Homing Capacity Between Mesenchymal Stromal Cells and Macrophages in Mouse Renal Injury Models
Authors: Taylor Arthur , Sharkey Jack , Harwood Rachel , Scarfe Lauren , Barrow Michael , Rosseinsky Matthew J. , Adams Dave J. , Wilm Bettina , Murray Patricia 
Published: December 2019

AbstractPurposeThe question of whether mesenchymal stromal cells (MSCs) home to injured kidneys remains a contested issue. To try and understand the basis for contradictory findings reported in the literature, our purpose here was to investigate whether MSC homing capacity is influenced by administration route, the type of injury model used, and/or the presence of exogenous macrophages.ProceduresTo assess the viability, whole-body biodistribution, and intra-renal biodistribution of MSCs, we used a multimodal imaging strategy comprising bioluminescence and magnetic resonance imaging. The effect of administration route (venous or arterial) on the ability of MSCs to home to injured renal tissue, and persist there, was assessed in a glomerular injury model (induced by the nephrotoxicant, Adriamycin) and a tubular injury model induced by ischaemia-reperfusion injury (IRI). Exogenous macrophages were used as a positive control because these cells are known to home to injured mouse kidneys. To assess whether the homing capacity of MSCs can be influenced by the presence of exogenous macrophages, we used a dual-bioluminescence strategy that allowed the whole-body biodistribution of the two cell types to be monitored simultaneously in individual animals.ResultsFollowing intravenous administration, no MSCs were detected in the kidneys, irrespective of whether the mice had been subjected to renal injury. After arterial administrationviathe left cardiac ventricle, MSCs transiently populated the kidneys, but no preferential homing or persistence was observed in injured renal tissue after unilateral IRI. An exception was when MSCs were co-administered with exogenous macrophages; here, we observed some homing of MSCs to the injured kidney.ConclusionsOur findings strongly suggest that MSCs do not home to injured kidneys.
Mercury dynamics in macroinvertebrates in relation to environmental factors in a highly impacted tropical estuary: Buenaventura Bay, Colombian Pacific
Authors: Gamboa-García Diego Esteban , Duque Guillermo , Cogua Pilar , Marrugo-Negrete José Luis 
Published: December 2019

AbstractThe environmental health of Buenaventura Bay, a highly impacted tropical estuary, is influenced by numerous human activities, including mining upstream. Large- and small-scale fishing plays an important role in the local economy, so we investigated the dynamic processes of bioaccumulation of mercury at basal trophic levels. Four samples were taken at each of the four locations in Buenaventura Bay during each of the four seasons of 2015. We measured the total mercury content (T-Hg, dry weight) in sediments and in muscle tissue across 17 macroinvertebrate species. The most abundant were the blue crab (C. arcuatus) and the mantis shrimp (S. aculeata aculeata). Blue crab showed an average muscle T-Hg value ​​exceeding the limit of 0.2 g·g-1, which is the maximum T-Hg level suggested for food consumption by vulnerable humans and populations: pregnant women, children, and the community that feeds from this source of protein on a daily basis. It was found that, 6.22% of individuals exceeded the 0.5 g·g-1level, which is the maximum T-Hg level suggested for food consumption by the general population: the population that consumes it sporadically. Significantly high values ​​of T-Hg in blue crab and mantis shrimp occurred during low salinity conditions in the estuary, suggesting that Hg mainly originates from river runoff during the rainy season. Nevertheless, the biota-sediment accumulation factor (BSAF) was favored in high salinity, which could mean greater availability of Hg for higher levels of the estuarine food web in the dry season and in marine waters. In general, the T-Hg levels in some samples exceeded 0.2 g·g−1. Therefore this pollutant must be monitored due to its biomagnification potential and as a threat to human health, especially that for the local population of fishermen and their families.
A randomised comparison of the effect of haemodynamic monitoring with CardioMEMS in addition to standard care on quality of life and hospitalisations in patients with chronic heart failure
Authors: Brugts J. J. , Veenis J. F. , Radhoe S. P. , Linssen G. C. M. , van Gent M. , Borleffs C. J. W. , van Ramshorst J. , van Pol P. , Tukkie R. , Spee R. F. , Emans M. E. , Kok W. , van Halm V. , Handoko L. , Beeres S. L. M. A. , Post M. C. , Boersma E. , Lenzen M. J. , Manintveld O. C. , Koffijberg H. , van Baal P. , Versteegh M. , Smilde T. D. , van Heerebeek L. , Rienstra M. , Mosterd A. , Delnoy P. P. H. , Asselbergs F. W. , Brunner-La Rocca H. P. , de Boer R. A. 
Published: December 2019

Abstract
Background
Assessing haemodynamic congestion based on filling pressures instead of clinical congestion can be a way to further improve quality of life (QoL) and clinical outcome by intervening before symptoms or weight gain occur in heart failure (HF) patients. The clinical efficacy of remote monitoring of pulmonary artery (PA) pressures (CardioMEMS; Abbott Inc., Atlanta, GA, USA) has been demonstrated in the USA. Currently, the PA sensor is not reimbursed in the European Union as its benefit when applied in addition to standard HF care is unknown in Western European countries, including the Netherlands.

Aims
To demonstrate the efficacy and cost-effectiveness of haemodynamic PA monitoring in addition to contemporary standard HF care in a high-quality Western European health care system.

Methods
The current study is a prospective, multi-centre, randomised clinical trial in 340 patients with chronic HF (New York Heart Association functional class III) randomised to HF care including remote monitoring with the CardioMEMS PA sensor or standard HF care alone. Eligible patients have at least one hospitalisation for HF in 12 months before enrolment and will be randomised in a 1:1 ratio. Minimum follow-up will be 1 year. The primary endpoint is the change in QoL as measured by the Kansas City Cardiomyopathy Questionnaire (KCCQ). Secondary endpoints are the number of HF hospital admissions and changes in health status assessed by EQ-5D-5L questionnaire including health care utilisation and formal cost-effectiveness analysis.

Conclusion
The MONITOR HF trial will evaluate the efficacy and cost-effectiveness of haemodynamic monitoring by CardioMEMS in addition to standard HF care in patients with chronic HF. Clinical Trial Registration number NTR7672.
The Myth of McMindfulness
Authors: Anālayo Bhikkhu 
Published: December 2019

AbstractThis article examines to what extent the teaching of mindfulness-based stress reduction (MBSR) can accurately be referred to by the term “McMindfulness.” The application of this term appears to rest on the expectation that teachers of MBSR and similar mindfulness programs, in order to be true to their Buddhist heritage, should inculcate political awareness in their patients, motivating them to resist the neoliberal capitalist system. Moreover, another assumption seems to be that present-moment awareness, viewed as another departure from ancient Indian Buddhism, prevents critical thinking and thereby supports obedient submission to exploitative conditions. Closer examination shows that expecting mindfulness teachers to stimulate political activism is not in keeping with relevant Buddhist antecedents. The relevant sources even testify to the employment of mindfulness for mere health benefits already in ancient India. Besides, the same textual sources show that mindfulness of the present moment is not a later innovation. The belief that such mindful presence disables critical thinking appears to mistake the goal of the cultivation of mindfulness for the mere absence of thoughts. At least as far as MBSR and related programs in healthcare are concerned, the term “McMindfulness” is not justified and its recent indiscriminate application to any contemporary mindfulness practice appears to have turned it into a myth. Rather than being merely a tool to ensure subservience to the neoliberal capitalist system, in view of the impending climate catastrophe, mindfulness can offer an important resource to face the ravages caused by unbridled exploitation of the environment.