bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimax-robust forecasting of sequences with periodically stationary long memory multiple seasonal increments
Authors: Luz Maksym , Moklyachuk Mikhail 
Published: August 2020

We introduce a stochastic sequence $\zeta(k)$ with periodically stationary generalized multiple increments of fractional order which combines cyclostationary, multi-seasonal, integrated and fractionally integrated patterns. We solve the problem of optimal estimation of linear functionals constructed from unobserved values of the stochastic sequence $\zeta(k)$ based on its observations at points $ k<0$. For sequences with known matrices of spectral densities, we obtain formulas for calculating values of the mean square errors and the spectral characteristics of the optimal estimates of the functionals. Formulas that determine the least favorable spectral densities and minimax (robust) spectral characteristics of the optimal linear estimates of the functionals are proposed in the case where spectral densities of the sequence are not exactly known while some sets of admissible spectral densities are given.
Eficiência energética em prédios de salas de aula naturalmente ventilados
Authors: Oliveira Wagner Costa , Cunha Eduardo Grala da , Leitzke Rodrigo Karini 
Published: August 2020

Em 2014, foi publicada a Instrução Normativa 02/2014, do Ministério do Planejamento, Desenvolvimento e Gestão, obrigando os projetos de edificações e os retrofit de edificações públicas federais, com mais de quinhentos metros quadrados de área, a serem desenvolvidos buscando a Etiqueta Nacional de Conservação de Energia de Projeto nível A, de acordo com os Requisitos Técnicos de Qualidade para o Nível de Eficiência Energética de Edifícios Comerciais, de Serviços e Públicos (RTQ-C). O objetivo deste trabalho é verificar se projetos de prédios de salas de aula licitados por Instituições Federais de Ensino Superior (IFES) atendem à determinação da IN 02/2014 e, em caso negativo, como intervir para os projetos atingirem nível A. Foram analisados dez prédios naturalmente ventilados licitados por quatro IFES do Rio Grande do Sul, seguindo os procedimentos indicados no RTQ-C. Também foram realizadas simulações para verificar o consumo hipotético de energia se os edifícios fossem condicionados artificialmente. Como resultado, 60% dos projetos conseguiram alcançar o nível mais alto de eficiência energética, atendendo à Instrução Normativa. Também se verificou que, nos casos negativos, a substituição das lâmpadas tubulares fluorescentes por lâmpadas LED equivalentes e especificação de bacias sanitárias econômicas bastaria para os projetos obterem a classificação máxima.
Comparing Alteration of MMSE (Mini-Mental State Examination) Scores as Cognitive Function Test in Geriatrics After General and Regional Anesthesia
Authors: Budianto Ferrie , Setiawan Philia , Hamzah Hamzah , Yulianti Erikavitri 
Published: August 2020

Introduction: An alteration of cognitive function in geriatrics often occurred after a surgery procedure. To do a surgery, patients would go through the process with anesthesia, whether it is general or regional anesthesia. We aimed to identify the effect of general and regional anesthesia in increasing the risk of alteration in cognitive function from geriatrics who underwent elective surgery followed by other risks. Material and Method: This observational analytic study has a total sample of 60 patients who aged 60 years or more, and half of the total sample underwent an elective surgery with general anesthesia, whereas the other half with regional anesthesia at Gedung Bedah Pusat Terpadu Dr. Soetomo General Hospital in a range of October – November 2016. The cognitive function of patients was assessed with MMSE which is done in approximately 10 – 15 minutes. Result and Discussion: There was a statistically significant correlation between age and both preoperative MMSE score also the alteration of MMSE score after 3 days in patients with regional anesthesia (P-value = 0.032; 0.044). Also, the correlation between educational status and preoperative MMSE score (P-value = 0.001). There was also a statistically significant difference in alteration of the MMSE score after 3 days between patients with general and regional anesthesia which went through the hypotension phase (P-value = 0.022; 0.003). We identified that both general and regional anesthesia could lead to alteration of MMSE score (P-value = 0.001; 0.02) and there was a statistically significant difference between both of them (P-value = 0.001). Conclusion: Both general and regional anesthesia could lower the cognitive function of geriatrics, especially general anesthesia which happened to have a higher risk to occur. Other factors such as age, educational status, and hemodynamic condition during surgery, had their impacts toward lowering cognitive function in geriatrics.
Molecular Characteristics of Indonesian Isolate <i>Enterocytozoon hepatopenaei</i> Based on Sequence Analysis of 18S rRNA Genes
Authors: Artanto Yohanes Kristiawan , Prayitno Slamet Budi , Sarjito Sarjito , Desrina Desrina , Haditomo Alfabetian Harjuna Condro 
Published: August 2020

ABSTRACT Enterocytozoon hepatopenaei (EHP) infection have been reported as an obstacle of whiteleg shrimp (Penaeus vannamei) culture in Indonesia. However, understanding of the molecular characteristics of EHP species in Indonesia is not widely known. The aims of this study were to determine the identity and characters of DNA, and their phylogeny of EHP species from several different locations in Indonesia with specific references to 18S rRNA gene. The EHPs were collected from cultured P.vannamei from Lampung, Pangandaran, Sidoarjo, Banyuwangi, Probolinggo, Blitar, Makassar, and Lombok. Thirteen (13) samples were randomly selected to explore their gene characters through 18S rRNA gene sequencing. The primers used were EHP_F and EHP_1R. Parameter observed were DNA sequencing, nucleotide sequence homology with related available genes in the Gen Bank database, multiple sequence alignment, and reconstruction of genetic relationship trees. DNA sequence homology analysis showed that all samples had 99.89-100% similarity to Indian Enterocytozoon hepatopenaei (Accession Number MH259890.1 and MH260592.1). The alignment results illustrated that all EHP sequences of Indonesian isolates were 100% identical each other. The phylogenetic tree topology provided information that all sample accessions were in the same clade and spread evenly. The conclusion were that the Indonesian EHP species were identical (100%) and it could be said that they were genetically homogeneous. Keywords: Enterocytozoon hepatopenaei, 18S rRNA gene, Indonesia.
MENINGKATKAN KUALITAS KARYA ILMIAH MAHASISWA MELALUI BIMBINGAN SELF REGULATED LEARNING
Authors: Latipah Eva 
Published: August 2020

<p><em>This study was conducted to design a guidance model of self regulated learning and test effectiveness of this model in improving quality of students scientific work.</em><em> </em><em>Design of model is done by identifying needs of students and apply model in guidance process of students scientific work. Subjects in this study are student who is writing their thesis numbered 42 people</em><em> in UIN Sunan KAlijaga Yogyakarta</em><em>.</em><em> The </em><em>results show that students need guidance on a strategy to complete thesis quickly and precisely. By applying that guidance model quality of students thesis increased significantly shown in value of thesis that be obtained.</em></p><p> </p>
Protocol for CardioCluster Creation
Authors: Monsanto Megan M , Sussman Mark A 
Published: August 2020

Abstract
Cellular therapy to treat heart failure is an ongoing focus of intense research, but with limited progress. Engineered augmentation of established cellular effectors overcomes impediments, enhancing reparative activity. Such ‘next generation’ implementation includes delivery of combinatorial cell populations working together synergistically. Concurrent isolation and expansion of three distinct cardiac-derived interstitial cell types from human heart tissue prompted design of a 3D structure that maximizes cellular interaction, allows for defined cell ratios, controls size, enables injectability, and minimizes cell loss. Here we describe a method wherein, mesenchymal stem cells (MSCs), endothelial progenitor cells (EPCs) and c-Kit+ cardiac interstitial cells (cCICs) when cultured together spontaneously form scaffold-free 3D microenvironments termed CardioClusters.
Non-Interactive Amblyopia Treatment Modalities in Children: A Systematic Review and Meta-Analysis
Authors: Hussen Mohammed Seid , Adimassu Nebiyat Feleke , Belete Gizachew Tilahun , Atnafu Asmamaw 
Published: August 2020

Abstract
Background: Recently, a number of clinical trials are conducting on amblyopia treatments. Discovering an intervention that provides optimal outcome with minimal subsidiary effect is an essential issue in medical arena. Therefore, this review aimed to identify the most effective and safest amblyopia interventions in an integrative manner. Methods: Eligible studies were identified from Cochrane library (CENTRAL), PubMed Central, Google Scholar, ScienceDirect, and Scopus electronic database. Data pooling was performed for trials with a little statistical heterogeneity (P>0.05, I 2 <50%) using the fixed-effect models. The mean difference (MD) and risk ratio (RR) at 95% confidence interval (CI) for visual acuity improvement, the success of the treatment, reverse amblyopia, and adherence rate was pooled. Results : Eight trials consisted of 1253 participants were included . The pooled mean visual acuity improvement was similar for both six hours and full time patching (MD, 0.00; 95% CI, -0.54 to 0.55). In subgroup analysis, all spectrum of patching are equally effective in treating mild to moderate amblyopia but 6 hours to full-time patching regimen are effective for severe amblyopia. The therapeutic outcome of patching was statistically preferable to atropine (pooled MD, 0.25 lines; 95% CI, 0.01 to 0.48). Besides, the incidence of reverse amblyopia was lower in patching groups as compared to atropine (pooled RR, 0.19; 95% CI: 0.06 to 0.57). However, the treatment adherence for patching was lesser, (pooled RR, 0.9; 95% CI, 0.84 to 0.96). Conclusion: Patching, particulary six-hours patching as a first line treatment provides optimal visual acuity improvement that balances the effect of reverse amblyopia and poor adhrence as compared to atropine and other spectrum of patching regimen but it should be under proactive monitoring to optimize the adherence issues.
Bone impaction grafting with trabecular metal augments in large defects in young patients: unravelling a new perspective in Surgical Technique
Authors: Torre-Escurero Basilio De la , Gómez-González Eva , Álvarez-Villar Slavador , Bujan Julia , Ortega Miguel A 
Published: August 2020

Abstract
Background: Acetabular reconstruction with bone impaction grafting in large defects has yielded conflicting results.Methods: This was a retrospective study of a case series of five patients with a young age (≤50 years) at the time of surgery who had large acetabular defects reconstructed by bone impaction grafting and trabecular metal augments. The mean follow-up was 79 months. We describe the surgical technique in detail.Results: Improvement was significant on the WOMAC and SF-36 scales (p < 0.05). The radiographs taken at the last follow-up examination showed no migration of the polyethylene cup (p = 0.31) or differences in the abduction angle (p = 0.27) compared to the radiographs from the immediate postoperative period. One patient presented two dislocation episodes as a complication.Conclusion: The combination of trabecular metal augments with the bone impaction grafting technique in young patients with large acetabular defects provides satisfactory results in the long term and restores the bone stock.
Maternal sevoflurane exposure affects differentiation of hippocampal neural stem cells by regulating microRNA-410-3p and ATN1
Authors: ZHANG YI , WU ZIYI , LI XINGYUE , WAN YUXIAO , ZHANG YINONG , ZHAO PING 
Published: August 2020

Abstract
Background Currently, numerous animal studies have shown that exposure to commonly used general anesthetics during pregnancy may cause neurocognitive impairment in the offspring. Reportedly, exposure to sevoflurane during mid-trimester of pregnancy can inhibit proliferation of neural stem cells (NSCs) and lead to early apoptosis. Whether exposure to sevoflurane during pregnancy affects the differentiation of NSCs remains unclear. Methods In the present study, pregnant rats were exposed to 3% sevoflurane once for 2 h on gestational day 14 (G14) or 3 times for 2 h on G13, G14, and G15. Next, the differentiation of NSCs was measured using neuron marker β-tubulin III and astrocyte marker glial fibrillary acidic protein (GFAP) in fetal brain tissues 24 h and 72 h after anesthesia and in hippocampus on postnatal day 28. Primary cultured rat NSCs were exposed to 4.1% sevoflurane to explore the mechanism. Results The results showed that during mid-trimester, multiple exposures to sevoflurane can cause premature differentiation of NSCs in developing brains of offspring and lead to long-term neuron reduction and astrocyte proliferation in hippocampus. The data from the present study indicated that repeated exposure to sevoflurane downregulated atrophin-1 (ATN1) expression and caused early differentiation of NSCs. Overexpression of ATN1 via lentivirus transfection attenuated the influence of sevoflurane. Using dual luciferase assay, ATN1 was found to be a target gene of microRNA‐410-3p (miR‐410-3p). MiR-410-3p suppression via lentivirus transfection recovered the ATN1 expression and differentiation of NSCs. Conclusions The results from the present study demonstrated that repeated exposure to sevoflurane leads to early differentiation of NSCs and long-term effects via the miR-410-3p/ATN1 pathway.
Linking the Effect of Psoriatic Arthritis-Related Foot Involvement to the Leeds Foot Impact Scale using the International Classification for Functioning, Disability and Health: A Study to Assess Content Validity.
Authors: Carter Kate , Tannous Caterina , Walmsley Steven , Rome Keith , Turner Deborah E 
Published: August 2020

Abstract
Background Previous research to describe the impact of foot involvement in psoriatic arthritis has used the Leeds Foot Impact Scale in Rheumatoid Arthritis (LFIS-RA) in the current absence of any psoriatic arthritis foot-specific tools. However, the LFIS-RA is a rheumatoid arthritis disease-specific outcome measure and its content validity for evaluating the experiences of people with psoriatic arthritis-related foot involvement is unknown. The study objective was to determine the content validity of the LFIS-RA for assessing people with psoriatic arthritis, using the International Classification of Functioning, Disability and Health (ICF) as the frame of reference.Method Concepts within each item of the LFIS-RA were linked to the best-matched ICF categories using established linking rules, which enable a systematic and standardised linking process. All concepts were independently linked to the ICF by 2 investigators with different professional backgrounds, which included occupational therapy and podiatry. The list of ICF categories derived from previous research that pertained to the foot in psoriatic arthritis was then compared with the ICF categories linked to the LFIS-RA. The comparison was undertaken in order to determine the extent to which concepts important and relevant to people with psoriatic arthritis-related foot involvement were addressed. Results Thirty-five distinct ICF categories were linked to the LFIS-RA, which related to body functions (44%), activities and participation (35%), environmental factors (16%) and body structure (5%). In comparison with the ICF categories derived from concepts of the foot in psoriatic arthritis previously defined, the LFIS-RA provided coverage of key constructs including pain, functioning, daily activities, footwear restrictions and psychological impact. Other concepts of importance in psoriatic arthritis such as skin and toenail involvement, self-management and paid employment were not addressed in the LFIS-RA. Conclusion Content validity of the LFIS-RA to determine the impact of foot functional impairments and disability in people with psoriatic arthritis was not supported by the results of this study. Future work should consider the development of a psoriatic arthritis foot-specific patient reported outcome measure, using the LFIS-RA as an important foundation.
Recommendations to Improve Physical Activity Prescription for the Cystic Fibrosis Population: An Irish Perspective
Authors: Hurley Nicola , Kehoe Bróna , McCaffrey Noel , Redmond Karen , Cullen Lydia , Moyna Niall M. 
Published: August 2020

Abstract
Background: Physical activity (PA) is a well-established therapeutic modality for the maintenance and improvement of long-term health in cystic fibrosis (CF). Health care professionals (HCP) play a significant role in the promotion of PA behaviours. Limited research exists investigating the extent of PA prescription within CF care. This study aimed to identify Irish HCP i) knowledge and practice of prescribing PA, ii) motivation and barriers of PA prescription; and iii) proposed strategies to optimize PA promotion and prescription in CF populations.Methods: 48 HCP (physiotherapists n=24, other n=24) from six CF centers in Ireland and members of the national physiotherapy clinical interest group completed a 30-item online survey. Results: Most HCP (81%) acknowledged that discussing PA with CF patients was part of their professional role. Almost all physiotherapists (95%) reported having sufficient knowledge regarding PA prescription, compared to 17% of other HCP. All physiotherapists reported discussing PA at every patient interaction, with 81% employing the current consensus guidelines, compared to 33% and 5% of other HCP, respectively. Among the most common barriers reported by HCP to prescribing PA to their CF patients were; lack of motivation and compliance among patients to adhere to PA advice, limited availability of PA programmes to refer their patients to, limited time with patients during clinic visits, lack of knowledge regarding PA prescription for CF care, and patients’ health status deeming PA inappropriate. Three-quarters of HCP reported a need to improve PA services for CF patients in Ireland.Conclusion: As people with CF are living longer, it is imperative that HCP are expanding their scope of practice to consistently include discussions around PA at every patient visit, as physical fitness has been shown to be a key predictor of longevity and quality of life in patients with CF. Formal educational opportunities in the form of continuing professional development programmes, with respect to PA prescription for CF populations, are warranted for CF HCP to optimize long-term patient management and outcomes. There is also a need to introduce or enhance motivational interviewing during patient interactions, to elicit positive PA behaviour change.
New Immunotherapy Biomarker N-Cadherin Rescue Immunosuppress Caused by PD-L1/IDO-1 in Prostate Cancer
Authors: Sun Yi , Guo Ju , Reiter Robert E , Xu Huan , Huang Jiao , Wei Qiang , Yang Lu 
Published: August 2020

Abstract
The authors have withdrawn this preprint due to author disagreement.
The Comparation of Ultrasound and Fluoroscopy-guided for Determining Puncture Entry Point of Percutaneous Vertebroplasty
Authors: Ye Sen , Lai Xiaorong , Zhong Lingjian , Yu Changzhang , Lu Wen , Xie Zhiquan , Zhang Gansheng , Chen Xuhan , Chen Yanzhen 
Published: August 2020

Abstract
Objective: The purpose of this study was to compare the safety and efficacy of ultrasound and fluoroscopy-guided for determining the puncture entry point of percutaneous vertebroplasty (PVP). Methods: From November 2018 to December 2019, a total of 50 eligible patients with thoracolumbar osteoporotic vertebral compression fractures (OVCFs) treated by PVP were retrospectively collected, of which 25 cases were in ultrasound-guided group and the other 25 cases were in fluoroscopy-guided group. Radiation doses, one-time localization success rate, operation time, clinical efficacy and complications incidence were compared between the two groups.Results: Ultimately, 46 patients completed followed-up, whose average follow-up time was 9 months, the dose and times of fluoroscopy and operation time in ultrasound-guided group statically significantly decreased compared to fluoroscopy-guided group (P<0.01). The one-time localization success rate in ultrasound-guided group and fluoroscopy-guided group were 68.2% and 37.5% respectively (x2= 4.33, P=0.037), whose difference was statistically significant (P<0.01). However, there was no significant difference in the visual analog scale (VAS) scores of back pain relief between the two groups (P>0.05). There were no postoperative complications such as infection, hematoma formation and fracture nonunion obsereved between the two groups.Conclusion: Ultrasound-guided entry point determination for PVP puncture is safe, which can significantly improve the success rate of one-time localization and decrease radiation exposure and operation time.
Screening test Accuracy of Portable Devices that can be used to Perform Colposcopy for Detecting CIN2+ in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis
Authors: Taghavi Katayoun , Rohner Eliane , Basu Partha , Low Nicola , Rutjes Anne , Bohlius Julia 
Published: August 2020

Abstract
Objective: Portable devices that can be used to perform colposcopy may improve cervical cancer screening in low- and middle- income countries (LMIC) where access to colposcopy is limited. The objective of this study was to systematically review the diagnostic test accuracy (DTA) of these devices for the detection of cervical intraepithelial neoplasia grade 2 or higher (CIN2+). Methods: In accordance with our protocol (Prospero CRD42018104286), we searched Embase, Medline and the Cochrane Controlled Register of Trials up to 9/2019. We included DTA studies, which investigated portable devices with moderate-to-high optical magnification (≥6x) for colposcopy, as described in the manual for Colposcopy and Treatment by the International Agency for Research on Cancer, with a histopathological reference standard. We used the QUADAS-2 tool to assess study quality. We examined results for sensitivity and specificity in paired forest plots, stratified by stages in the clinical pathway. We pooled estimates of test accuracy for the index test, used as an add-on to other tests, using a bivariate random-effect model.Results: We screened 1737 references and assessed 239 full-text articles for eligibility. Five single-gate DTA studies, including 2693 women, met the inclusion criteria. Studies evaluated two devices (GynocularTM and Pocket) at different stages of the screening pathway. In three studies, which used the index test in an add-on capacity in 1273 women, we found a pooled sensitivity of 0.79 (95% CI: 0.55-0.92) and specificity of 0.83 (95% CI: 0.59-0.94). The main sources of bias were partial verification, incorporation and classification bias.Conclusion: Few studies have evaluated portable devices able to perform colposcopy, so their accuracy for the detection of CIN2+ remains uncertain. Future studies should include patient-relevant and long-term outcomes, including missed cases, overtreatment, residual and recurrent disease. To meet the challenge of eliminating cervical cancer in LMIC, methods for visual assessment of the cervix need urgent redress.Registration: Prospero, International prospective register of systematic reviews (CRD42018104286). Date of registration 27, July, 2018.