bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, anticancer activity, and β‐lactoglobulin binding interactions of multitargeted kinase inhibitor sorafenib tosylate (SORt) using spectroscopic and molecular modelling approaches
Authors: Tanzadehpanah Hamid , Bahmani Asrin , Hosseinpour Moghadam Neda , Gholami Hamid , Mahaki Hanie , Farmany Abbas , Saidijam Massoud 
Published: July 2020

AbstractSorafenib tosylate (SORt) is an oral multikinase inhibitor used for treatment of advanced renal cell, liver, and thyroid cancers. In this study, this drug was synthesized and its antiproliferative activities against HCT116 and CT26 cells were assessed. The interaction of SORt with β‐lactoglobulin (BLG) was studied using different fluorescence techniques, circular dichroism (CD), zeta potential measurements, and docking simulation. The results of infrared (IR), mass, HNMR, and CNMR spectra demonstrated that the drug was produced with high quality, purity, and efficiency. SORt showed potent cytotoxicity against HCT116 and CT26 cells with IC50 of 8.12 and 5.42 μM, respectively. For BLG binding of SORt, the results showed that static quenching was the cause of the high affinity drug–protein interaction. Three‐dimensional fluorescence and synchronous spectra indicated that SORt conformation was changed at different levels. CD suggested that the α‐helix content remained almost constant in the BLG–SORt complex, whereas random coil content decreased. Zeta potential values of BLG were more positive after binding with SORt, due to electrostatic interactions between BLG and SORt. Thermodynamic parameters confirmed van der Waals and hydrogen bond interactions in the complex formation. Molecular modelling predicted the presence of hydrogen bonds and electrostatic forces in the BLG–SORt system, which was consistent with the experimental results.
Brain death following ingestion of E‐cigarette liquid nicotine refill solution
Authors: Scarpino Maenia , Bonizzoli Manuela , Lanzi Cecilia , Lanzo Giovanni , Lazzeri Chiara , Cianchi Giovanni , Gambassi Francesco , Lolli Francesco , Grippo Antonello 
Published: July 2020

AbstractBackgroundThe use of electronic cigarettes (e‐cigarettes) is very common worldwide. To date, an increase of nicotine intoxication following an accidental or intentional ingestion/injection of refill solution (e‐liquid) has been detected.CaseA 23‐year‐old man presented with sudden loss of consciousness, bradycardia, and respiratory muscle paralysis after intentional ingestion of e‐liquid. Early clinical data, brain computed tomography, and neurophysiological tests (electroencephalogram [EEG] and somatosensory evoked potentials [SEPs]) did not show features with a poor neurological prognostic meaning of an hypoxic encephalopathy. After 4 days, the patient showed bilateral loss of the pupillary reflex, and severe and cytotoxic edema was detected on brain magnetic resonance imaging. SEPs showed a bilateral loss of cortical responses and EEG a suppressed pattern. Nine days after the onset of coma, the patient evolved toward brain death (BD).DiscussionBecause nicotine intoxication might cause respiratory muscle paralysis, without cardiac arrest (CA), it would be important to understand the mechanisms underlying brain damage and to take into account that the current neurological prognostic evidence for hypoxic–ischemic encephalopathy, based on data from patients who all experienced CA may not be reliable. Reporting cases of nicotine intoxication through e‐liquid is relevant in order to improve regulatory parameters for e‐liquid sale.
Impact of public health emergency response to COVID‐19 on management and outcome for NSTEMI patients in Beijing: A single‐center historic control
Authors: Liu Shuai , Song Chenxi , Yin Dong , Wang Yang , Zhao Yanyan , Yang Weixian , Qiao Shubin , Dou Kefei , Xu Bo 
Published: July 2020

AbstractBackgroundDuring coronavirus disease 2019 (COVID‐19) epidemic, reducing the number of invasive procedure and choosing conservative medication strategy for patients with non‐ST‐segment elevation myocardial infarction (NSTEMI) is unavoidable. Whether this relatively conservative strategy will impact in‐hospital outcome for NSTEMI patients remains unclear.Methods and ResultsThe current study included all consecutive NSTEMI patients who visited the emergency department in Fuwai Hospital from February 1 to March 31, 2020 and all the NSTEMI patients in the same period of 2019 as a historical control. Very‐high‐risk patients were defined as clinical presentation of heart failure, cardiac shock, cardiac arrest, recurrent chest pain, and life‐threatening arrhythmias. The primary outcome was in‐hospital major adverse cardiac events (MACE), defined as a composite of all‐cause death, recurrent myocardial infarction, or heart failure. A total of 115 NSTEMI patients were enrolled since the outbreak of COVID‐19, and a total of 145 patients were included in the control group. There was a tendency toward higher MACE risk in 2020 compared with 2019 (18.3% vs. 11.7%, p = .14). Among very‐high‐risk patients, early percutaneous coronary intervention (PCI) strategy in 2019 was associated with reduced MACE risk compared with delayed PCI in 2020 (60.6% [20/33] in 2020 vs. 27.9% [12/43] in 2019, p = .01).ConclusionsCOVID‐19 pandemic results in a significant reduction in immediate/early PCI and a trend toward higher adverse event rate during hospitalization, particular in very‐high‐risk patients.
Outcomes of percutaneous coronary interventions in patients with liver transplant
Authors: Shah Harshil , Ramineni Gowthami , Varghese Rinu , Thwe Ei Ei , Hassan Maysar , Abdul‐lattif Eahab , Shah Priyal , Sarker Khadiza , Patel Achint , Gandhi Darshan , Solanki Shantanu 
Published: July 2020

AbstractObjectiveOur aim is to describe characteristics of liver transplant patients undergoing percutaneous coronary interventions (PCI) as well as in‐hospital outcomes including the mortality and peri‐procedural complications from the largest publicly available inpatient database in the United States from 2002 to 2014.BackgroundOutcomes of PCI are well studied in patients with end‐stage liver disease but not well studied in patients who receive liver transplant (LT).MethodsData derived from Nationwide Inpatient Sample (NIS) were analyzed for years 2002–2014. Adult Hospitalizations with PCI were identified using ICD‐9‐CM procedure codes. LT status and various complications were identified by using previously validated ICD‐9‐CM diagnosis codes. Endpoints were in‐hospital mortality and peri‐procedural complications. Propensity match analysis was performed to compare the endpoints between two groups.ResultsDuring the study period, 8,595,836 patients underwent PCI; 4,080 (0.04%) patients had prior LT status. 93% of patients were above age 59 years, 79% were males and 69% were nonwhites. Out of the total patients with LT status, 73% had hypertension, 57% had diabetes mellitus, and 47% had renal failure. Post‐PCI complications were studied further in both liver and non‐LT patients after 1:1 propensity match which showed the incidence of acute kidney injury (AKI) was higher in LT group (12.3 vs 10.7%, p = .024) but dialysis requiring AKI was similar.ConclusionAmong the LT recipients undergoing PCI, majority were nonwhite males. Almost more than half of the recipients had diabetes mellitus and renal failure. Incidence of AKI was higher in LT group, but other peri‐procedural complications were comparable.
Electronic Structure Based Intuitive Design Principle of Single‐Atom Catalysts for Efficient Electrolytic Nitrogen Reduction
Authors: Kumar Ritesh , Singh Abhishek K. 
Published: July 2020

AbstractAs an alternative to cost‐ and energy intensive Haber‐Bosch process, the implementation of electrolytic ammonia synthesis from dinitrogen molecule has been a long‐sought goal. State‐of‐the‐art electrocatalysts for nitrogen reduction reaction (NRR) face not only activity but also selectivity problem with the competitive hydrogen evolution reaction (HER). Recently, single‐atom catalysts (SACs) have emerged as promising for various reactions as they combine the best of homogenous and heterogenous catalysts. The reason for their high activity compared to their bulk and nanoparticle counterparts are yet to be completely understood. Inspired by the structure of nitrogenase FeMo cofactor, here we studied 13 transition metals anchored on MoS2 monolayer at Mo‐top positions, as possible electrolytic NRR catalysts using first‐principles methods. Employing the implicit solvation model, we calculated free energy barriers for proton abstraction by N2 molecule in end‐on configuration and adsorption free energy of hydrogen on all SACs. Based on these two parameters, Fe, Co, and Ru were found to be the most active and highly selective electrolytic NRR catalysts. Compared with other mechanisms, the limiting potentials (and hence activity) for enzymatic mechanism were found to be higher on these three SACs, with Ru SAC having a very low overpotential of 0.38 V vs SHE. Bader charge transferred from transition metal to N2 molecule and group number of transition metals correlate strongly with the NRR activity and hence emerge as two key descriptors for catalytic activity. These intuitive principles for rational designing of promising alternatives to the currently used bulk Ru(0001) catalyst could accelerate the search for highly efficient and selective SACs for electrolytic NRR.
Mesophilic and Thermophilic Anaerobic Digestion of Model Kitchen Waste with Variation of Fat Content
Authors: Sobon‐Mühlenbrock Elena , Schlienz Markus , Greger Manfred 
Published: July 2020

AbstractAnaerobic digestion of model kitchen waste (MKW) produced on basis of real kitchen waste (KW) is studied in batch tests. The impact of fat content of three MKWs (14.7 %, 23 %, and 27.2 % rapeseed oil content) on the biogas production at mesophilic and thermophilic conditions and two loadings is examined. The loading of 5 gVSL−1 leads to fast degradation under both temperature modes and the volume of biogas produced is only weakly correlated to the oil content. For the loading of 25 gVSL−1 a strong retardation of biogas production, high concentration of volatile fatty acids and no correlation of oil content is observed.
Asymmetric Deoxygenative Cyanation of Benzyl Alcohols Enabled by Synergistic Photoredox and Copper Catalysis†
Authors: Chen Hong‐Wei , Lu Fu‐Dong , Cheng Ying , Jia Yue , Lu Liang‐Qiu , Xiao Wen‐Jing 
Published: July 2020

Summary of main observation and conclusionAn enantioselective deoxygenative cyanation of benzyl alcohols was accomplished for the first time through the synergistic photoredox and copper catalysis. This reaction features the use of organic photosensitizer and low‐cost 3d metal catalyst, simple and safe operations, and extremely mild conditions. A variety of chiral benzyl nitriles were produced in generally good yields and high level of enantiocontrols from readily available feedstocks (22 examples, up to 93% yield and 92% ee).
On variable ordination of Cholesky‐based estimation for a sparse covariance matrix
Authors: Kang Xiaoning , Deng Xinwei 
Published: July 2020

AbstractEstimation of a large sparse covariance matrix is of great importance for statistical analysis, especially in high‐dimensional settings. The traditional approach such as the sample covariance matrix performs poorly due to the high dimensionality. The modified Cholesky decomposition (MCD) is a commonly used method for sparse covariance matrix estimation. However, the MCD method relies on the order of variables, which often is not available or cannot be pre‐determined in practice. In this work, we solve this order issue by obtaining a set of covariance matrix estimates based on assuming different orders of variables used in the MCD. Then we consider an ensemble estimator as the “centre” of such a set of covariance matrix estimates with respect to the Frobenius norm. Our proposed method not only ensures that the estimator is positive definite, but also captures the underlying sparse structure of the covariance matrix. Under some regularity conditions, we establish both algorithmic and asymptotic convergence of the proposed method. Its merits are illustrated via simulation studies and a practical example using data from a prostate cancer study.
Oxygen Vacancy‐Engineered Ti−Mo−Ni Ternary Oxide Nanotubes as Binder‐Free Supercapacitor Electrodes with Exceptional Potential Window
Authors: Deyab Nourhan M. , Ahmed Nashaat , Allam Nageh K. 
Published: July 2020

AbstractThe charge storage performance of metal oxides as electrochemical supercapacitor electrodes is limited by their poor conductivity and limited operating potential window. Herein, we report on the oxygen‐vacancy engineering of Ti−Mo−Ni−O nanotubes via hydrogen annealing to boost their capacitive performance. Hydrogen treatment of the nanotubes resulted in 110% increase in specific capacitance as compared to the air‐annealed counterpart with excellent stability over 3700 cycles and an exceptional capacitance retention of 99%. The observed enhancement can be ascribed to the faradaic capacitance contribution from the several redox pairs of Nickel, Molybdenum, and Ti3+. This was further confirmed via the electrochemical impedance spectroscopy measurements, revealing a drastic decrease in the internal resistance upon hydrogen treatment. We hope our demonstrated two‐step interfacial engineering opens a new strategy to design high performance electrode materials for advanced electrochemical supercapacitors.
Synthesis and Antitumor Activity Evaluation of Cyclometalated 2H‐Indazole Ruthenium(II) and Iridium(III) Complexes
Authors: Rao Ramdas Nishanth , Panchangam Rajeeva Lochana , Manickam Venkatraman , Balamurali Musuvathi Motilal , Chanda Kaushik 
Published: July 2020

AbstractIn this work, a series of novel C−N cyclometalated 2H‐indazole Ru(II) and Ir(III) complexes were synthesized, wherein chelating ligands with substituents like H, and isopropyl group in the R4 position of the phenyl ring of the 2H‐indazole chelating ligand are present. The cytotoxicity of Ru(II) and Ir(III) complexes has been evaluated against different human cancer cell lines (HeLa, MCF‐7, and A549) in a concentration‐dependent manner. The new iridium complex with isopropyl substituent in the phenyl ring of the 2H‐indazole moiety showed good cytotoxic activity against MCF‐7 cells with an IC50 value 3.5 μM. The complex also exhibited cytotoxicity comparable to that of cisplatin. The ability of this compound inducing apoptosis was tested by nuclear condensation, cell membrane blebbing and caspase 3/7 activation. Further, this iridium complex is capable of inhibiting cancer cell migration when tested in MCF‐7 cell line. Subsequently, we have studied the DNA binding and protein binding ability of the newly synthesized iridium complex.
Channel aware wireless body area network with cognitive radio technology in disaster cases
Authors: Cicioğlu Murtaza , Çalhan Ali 
Published: July 2020

SummaryToday, developments in wireless technologies and the increase in disaster cases reveal the necessity of various wireless technologies cooperation. Several technologies are able to cooperate with each other for eHealth, IoT, and so forth applications in disaster cases with the pros and cons of today's communications. Wireless Body Area Networks (WBAN) and cognitive radio (CR) are promising technologies that can be used together to troubleshoot communication problems and make rescue operations successful in disaster situations. WBAN is a radio frequency‐based wireless network technology that aims to monitor the functions and conditions of the human body through the sensor nodes that form a network. CR proposes solutions to current problems of wireless communications such as spectrum scarcity and inefficient use of the spectrum. In this study, CR‐based WBAN architecture is proposed in disaster cases, and so the emergency, time‐critical, and vital signs of WBAN users (endangered people and rescue team members) are able to reach the health unit or disaster management unit in an opportunistic way. CR technology is integrated with a WBAN architecture utilizing the CSMA/C‐based IEEE 802.15.6 standard, and performance analysis is executed with the Riverbed Modeler simulation software. Furthermore, using the channel bonding technique, the throughput, the delay, the packet delivery ratios, and energy consumption ratios of the proposed architecture are investigated. According to the results, it was found that CR‐based WBAN architecture was 25% more successful in energy efficiency and 5% more successful in packet delivery ratio with channel bonding technique than the traditional WBAN.
Microtubules provide guidance cues for myofibril and sarcomere assembly and growth
Authors: Dhanyasi Nagaraju , VijayRaghavan K. , Shilo Ben‐Zion , Schejter Eyal D. 
Published: July 2020

AbstractBackgroundMuscle myofibrils and sarcomeres present exceptional examples of highly ordered cytoskeletal filament arrays, whose distinct spatial organization is an essential aspect of muscle cell functionality. We utilized ultra‐structural analysis to investigate the assembly of myofibrils and sarcomeres within developing myotubes of the indirect flight musculature of Drosophila.ResultsA temporal sequence composed of three major processes was identified: subdivision of the unorganized cytoplasm of nascent, multi‐nucleated myotubes into distinct organelle‐rich and filament‐rich domains; initial organization of the filament‐rich domains into myofibrils harboring nascent sarcomeric units; and finally, maturation of the highly‐ordered pattern of sarcomeric thick (myosin‐based) and thin (microfilament‐based) filament arrays in parallel to myofibril radial growth. Significantly, organized microtubule arrays were present throughout these stages and exhibited dynamic changes in their spatial patterns consistent with instructive roles. Genetic manipulations confirm these notions, and imply specific and critical guidance activities of the microtubule‐based cytoskeleton, as well as structural interdependence between the myosin‐ and actin‐based filament arrays.ConclusionsOur observations highlight a surprisingly significant, behind‐the‐scenes role for microtubules in establishment of myofibril and sarcomere spatial patterns and size, and provide a detailed account of the interplay between major cytoskeletal elements in generating these essential contractile myogenic units.
Proposal of micro plasma extraction device by autonomous trigger control
Authors: Naito Hiroki , Okamoto Shunya , Ukita Yoshiaki 
Published: July 2020

AbstractIn this paper, we report on the development of a microfluidic device, which extracts plasma from low‐volume whole blood (10 μL), and is aimed at integration with microfluidic system for micro analytical systems. The device autonomously separates blood cells and transfers the separated plasma by steady rotation. Based on the original autonomous fluidic control theory, we developed the principle of automatic timed injection of pressurizing medium into the separation chamber. This realizes the transferring of separated plasma from blood separation chamber to the other place, after separating blood cells by centrifugal force. Through the demonstration on a polydimethylsiloxane microfluidic device, we confirmed that the automatic plasma extraction was successfully implemented as designed. The efficiency of separation was evaluated on the basis of the concentrations of blood cells in samples before and after extraction, and the rate of blood cell removal was 98.5%.
Superior three‐dimensional perovskite catalyst for catalytic oxidation
Authors: Han Ning , Wang Shuo , Yao Zhengxin , Zhang Wei , Zhang Xuan , Zeng Lin , Chen Ruofei 
Published: July 2020

AbstractDue to the fact that traditional heavy metal‐based catalysts toward wastewater treatment could cause the problem of secondary contamination, it is imperative to seek for more eco‐friendly catalysts to address this tricky issue. Recently, numerous novel metal‐based heterogeneous catalysts, especially perovskite oxides, have been widely investigated for the activation of peroxymonosulfate (PMS), which is significant in the removal of organic pollutants. Here, we report a novel perovskite oxide (La0.7Sr0.3)CoO3‐δ (LSC)‐based 3D ceramic hollow fiber catalyst for aqueous‐phase advanced oxidation. Through it cooperating with PMS, the methylene blue (20 ppm) can be completely degraded only about 30 minutes. The mechanism of advanced oxidation process is explored via the electron paramagnetic resonance test on the active species. In addition, it also displays high activity for the degradation of other pollutes, such as tetrabromobisphenol A and rhodamine B. This study provides a new strategy to effectively degrade contaminant via introducing 3D ceramic catalysts.image
Steam reforming of tar from raw coke oven gas over bifunctional catalysts: Reforming performance for H2 production
Authors: Zhang Weidong , Xie Huaqing , Yu Zhenyu , Wang Panlei , Wang Zhengyu , Yu Qingbo 
Published: July 2020

AbstractIn this article, the bifunctional NiO/CaO@C12A7 catalysts having reforming catalytic effect and CO2 adsorption effect were prepared with co‐precipitation method, and were used in the sorption‐enhanced steam reforming process of tar from RCOG for hydrogen production. Among six kinds of samples with different load ratios, the catalyst with the CaO:C12A7:NiO ratio of 70:15:15 showed the best catalytic performance for the steam reforming of tar to produce H2 as well as the excellent characterization. Under the action of this catalyst, the H2 yield obtained from the steam reforming process of 1‐methylnaphthalene (C11H10) as the tar model compound were higher than that from the common steam reforming process, and the best H2 yield was obtained at the reforming temperature of 750°C, the S/C ratio of 12 and the WHSV of 0.055 hr−1, with the value of 83.9%.
Paper mill wastewater treatment by Fe2+ and heat‐activated persulfate oxidation: Process modeling and optimization
Authors: Can‐Güven Emine , Guvenc Senem Yazici , Kavan Nihal , Varank Gamze 
Published: July 2020

AbstractThis study investigated Chemical Oxygen Demand (COD) and turbidity removal from paper mill industry wastewater via Fe2+/heat‐activated persulfate oxidation. A mathematical model was developed, and the process variables (pH, reaction time, PS/COD, Fe2+ concentration for Fe2+‐activated PS, and temperature for heat‐activated PS) were optimized using the Response Surface Methodology and Central Composite Design methods. Under the optimum conditions, respectively, 70.9 and 99.4% COD and turbidity removal efficiencies were obtained for Fe2+‐activated PS oxidation, while 56.1 and 98.9% COD and turbidity removal efficiencies were determined for heat‐activated PS oxidation. The results indicated that both processes are efficient for paper mill industry wastewater treatment, and central composite design is an appropriate method for designing and optimizing process parameters.