bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methods for selecting the best evidence to inform a NICE technology appraisal on selective internal radiation therapies for hepatocellular carcinoma
Authors: Wade Ros , Sharif-Hurst Sahar , Harden Melissa , Walton Matthew , Claxton Lindsay , Hodgson Robert , Eastwood Alison 
Published: August 2020

Abstract
Background
Systematic reviews of medical devices are particularly challenging as the quality of evidence tends to be more limited than evidence on pharmaceutical products. This article describes the methods used to identify, select and critically appraise the best available evidence on selective internal radiation therapy devices for treating hepatocellular carcinoma, to inform a technology appraisal for the National Institute for Health and Care Excellence.

Methods
A comprehensive search of ten medical databases and six grey literature sources was undertaken to identify studies of three devices (TheraSphere®, SIR-Spheres® and QuiremSpheres®) for treating hepatocellular carcinoma. The large evidence base was scoped before deciding what level of evidence to include for data extraction and critical appraisal. The methodological quality of the included studies was assessed using criteria relevant to each study design.

Results
Electronic searches identified 4755 records; over 1000 met eligibility criteria after screening titles and abstracts. A hierarchical process was used to scope these records, prioritising comparative studies over non-comparative studies, where available. One hundred ninety-four full papers were ordered; 64 met the eligibility criteria. For each intervention, studies were prioritised by study design and applicability to current UK practice, resulting in 20 studies subjected to critical appraisal and data extraction. Only two trials had a low overall risk of bias. In view of the poor quality of the research evidence, our technology appraisal focused on the two higher quality trials, including a thorough critique of their reliability and generalisability to current UK practice. The 18 poorer quality studies were briefly summarised; many were very small and results were often contradictory. No definitive conclusions could be drawn from the poorer quality research evidence available.

Conclusions
A systematic, pragmatic process was used to select and critically appraise the vast quantity of research evidence available in order to present the most reliable evidence on which to develop recommendations.

Systematic review registration
PROSPERO CRD42019128383.
Agricultural policies, agricultural production and rural households’ welfare in Ethiopia
Authors: Shikur Zewdie Habte 
Published: August 2020

AbstractThe paper employs the computable general equilibrium (CGE) model of the Oromia region of Ethiopia to assess the macroeconomic impacts of agricultural policy on agricultural growth and rural households’ social welfare. The analysis is based on social accounting matrix (SAM) of Oromia region. This Oromia SAM is employed as a framework to estimate the effects of policy shocks on rural households’ social welfare. This SAM provides base year data needed for policy simulation in CGE model of Oromia region. This study develops two simulations based on economic assumptions and tests their effects on agricultural production, and social welfare. The first set of experiment focuses on the irrigation policies that change the factor intensities in the production of agricultural commodities, and the second one focuses on the precision agriculture that raises agricultural productivity in the use of technologies. The analysis identifies that irrigation scaling up has a positive effect on agricultural production, and social welfare. The application of precision agriculture generates a significant and positive effect on agricultural productivity and production, and rural households’ income and consumption. This finding suggests that price support policy should be implemented simultaneously with suggested policies.
Eating disorders among patients with borderline personality disorder: understanding the prevalence and psychopathology
Authors: Khosravi Mohsen 
Published: August 2020

Abstract
Background
Treatment protocols can be bolstered and etiological and maintenance factors can be recognized more easily by a superior understanding of emotions and emotion regulation in the comorbidity of borderline personality disorder (BPD) and feeding and eating disorders (FEDs). Therefore, the present study aimed at investigating the prevalence and psychopathology of FEDs in patients with BPD.

Methods
In this cross-sectional study, 220 participants were examined in three groups, namely BPD (n = 38), BPD + FEDs (n = 72), and healthy controls (n = 110), from August 2018 to November 2019. The participants were selected by systematic random sampling among the patients who referred to Baharan psychiatric hospital in Zahedan, Iran, with the sampling interval of 3. The subjects were evaluated by 28-item General Health Questionnaire (GHQ-28), Borderline Personality Inventory (BPI), Structured Clinical Interview for DSM-5 Personality Disorders (SCID-5-PD), Structured Clinical Interviews for DSM-5: Research Version (SCID-5-RV), the 26-item Eating Attitudes Test (EAT-26), 20-item Toronto Alexithymia Scale (TAS-20), Beck Anxiety Inventory (BAI), and Beck Depression Inventory-II (BDI-II).

Results
The results showed a 65.4% (n = 72) prevalence of FEDs in patients with BPD. Also, the highest and lowest prevalence rates were reported for other specified feeding and eating disorders (51.3%) and bulimia nervosa (6.9%), respectively. Although the highest mean score of TAS-20 was related to anorexia nervosa, there was no significant difference between the scores of various types of FEDs. The mediation analysis showed that anxiety and depression would play a mediating role in the relationship between alexithymia and eating-disordered behaviors.

Conclusions
The results have suggested that alexithymia, anxiety, and depression should receive clinical attention as potential therapeutic targets in the comorbidity of BPD and FEDs. The clinical implications of the research have been conducted to date, and directions for future research have been discussed.
Silver nanoparticles in orthodontics, a new alternative in bacterial inhibition: in vitro study
Authors: Jasso-Ruiz Irania , Velazquez-Enriquez Ulises , Scougall-Vilchis Rogelio José , Morales-Luckie Raúl Alberto , Sawada Toshiko , Yamaguchi Ryozo 
Published: August 2020

Abstract
Background
The purpose of the study is to assess the antiadherent and antibacterial properties of surface-modified different orthodontic brackets with silver nanoparticles against Streptococcus mutans and Streptococcus sobrinus, using radiomarker.

Methods
In this study evaluated quantitatively the adherence of Streptococci to orthodontic brackets, 300 samples of orthodontic brackets were selected and classified in to 10 groups as follow: GIn (InVu-Roth), GIIn (System-AlexanderLTS), GIIIn (Gemini-Roth), GIVn (NuEdge-Roth), GVn (Radiance plus-Roth), GVI (InVu-Roth), GVII (System-AlexanderLTS), GVIII (Gemini-Roth), GIX (NuEdge-Roth), GX (Radiance plus-Roth). All the samples were sonicated and Streptococci were cultivated by gender. A radioactive marker (3H) was used to codify the bacteria and measure them. After that, the brackets were submerged in a radiolabelled solution, and the radiation was measured. The statistical analysis was calculated with ANOVA test (Sheffè post hoc).

Results
The results showed significant differences were found among the groups. GIIIn shown the lowest scores for both bacteria; in contrast, GIX for Streptococcus mutans and GVI for Streptococcus sobrinus were the highest values.

Conclusions
Surface modification of orthodontic brackets with silver nanoparticles can be used to prevent the accumulation of dental plaque and the development of dental caries during orthodontic treatment.
The impacts of infectious complications on outcomes in acute pancreatitis: a retrospective study
Authors: Jiang Xun , Shi Ji-Yu , Wang Xia-Yu , Hu Yong , Cui Yun-Feng 
Published: August 2020

Abstract
Background
The occurrence of infectious complications characterizes the more severe forms of acute pancreatitis (AP) and is associated with high mortality. We investigated the effects of infection at different sites in patients with AP, including those with necrotizing pancreatitis (NP).

Methods
We conducted a retrospective analysis of 285 patients who met the inclusion criteria for AP and were admitted to Tianjin Nankai Hospital between January 2016 and September 2019. According to the source of the culture positivity during hospitalization, patients were divided into four groups: sterile group(n = 148), pancreatic infection group(n = 65), extrapancreatic infection group(n = 22) and combined infection group(n = 50). The source of infection, microbiology, biochemical parameters and prognostic indicators were analyzed.

Results
In terms of baseline characteristics, the four groups were similar in age, sex, aetiology, previous pancreatitis and diabetes. Compared with the severity of the disease in the other groups, the APACHE II scores(9.91 ± 4.65, 9.46 ± 5.05, respectively) and organ failure rate (40.9 and 50%, respectively)were higher in the extrapancreatic infection group and the combined infection group (P < 0.05). The frequency of surgical intervention and hospitalization time in patients with NP complicated with extrapancreatic infection was greatly increased (P < 0.05). Regarding the primary outcome, patients in the combined infection group had longer hospital stays (68.28 ± 51.80 vs 55.58 ± 36.24, P < 0.05) and higher mortality (24.0% vs 9.2%, P < 0.05) than patients in the pancreatic infection group. In addition, patients in the extrapancreatic infection group also showed high intensive care utilization (59.1%) and mortality rates (18.2%). Among the 137 AP patients with infection complications, 89 patients exhibited multidrug-resistant (MDR) microorganisms, and the mortality rate of patients with MDR bacterial infection was higher than that of patients with non-MDR bacterial infection (24.7% vs 3.6%, P = 0.001).

Conclusion
Clinicians should be aware that extrapancreatic infection (EPI) significantly aggravates the main outcome in pancreatic infection patients. Infection with MDR bacteria is also associated with AP mortality.
Family history of chronic illness, preterm gestational age and smoking exposure before pregnancy increases the probability of preeclampsia in Omo district in southern Ethiopia: a case-control study
Authors: Fikadu Kassahun , G/Meskel Feleke , Getahun Firdawek , Chufamo Nega , Misiker Direslign 
Published: August 2020

AbstractBackgroundPreeclampsia is a complex syndrome that is considered a disorder specific to pregnancy. However, research indicates that diffuse maternal endothelial damage may persist after childbirth. On the other hand, women who had a history of pre-eclampsia are at an increased risk of vascular disease. Considering that the multifactorial nature of pre-eclampsia in a remote health setting, knowledge of risk factors of preeclampsia gives epidemiological significance specific to the study area. Therefore, this study aimed to identify the determinants of preeclampsia among pregnant women attending perinatal service in Omo district Hospitals in southern Ethiopia.MethodsAn institution-based unmatched case-control study design was conducted among women visiting for perinatal service in Omo District public hospitals between February to August 2018. A total of 167 cases and 352 controls were included. Data were collected via face-to-face interviews. Bivariable and multivariable logistic regression analysis were computed to examine the effect of the independent variable on preeclampsia using Statistical Package for Social Sciences version 26 window compatible software. Variables with ap-value of less than 0.05 were considered statistically significant.ResultsFactors that were found to have a statistically significant association with pre-eclampsia were primary relatives who had history of chronic hypertension (AOR 2.1, 95% CI: 1.06–4.21), family history of diabetes mellitus (AOR 2.35; 95% CI: 1.07–5.20), preterm gestation(AOR = 1.56, 95%CI, 1.05–2.32), and pre-conception smoking exposure (AOR = 4.16, 95%CI, 1.1–15.4).ConclusionsThe study identified the risk factors for pre-eclampsia. Early detection and timely intervention to manage pre-eclampsia, and obstetric care providers need to emphasize women at preterm gestation and a history of smoking before pregnancy.
Association of Vitamin D Pathway Gene CYP27B1 and CYP2R1 Polymorphisms with Autoimmune Endocrine Disorders: A Meta-Analysis
Authors: Ma Xiaoxi , Xie Zhiguo , Qin Jiabi , Luo Shuoming , Zhou Zhiguang 
Published: August 2020

Abstract

Background
Studies on organ-specific autoimmune endocrine disorders showed correlations between disease risks and vitamin D pathways gene variants, such as CYP27B1 rs10877012 and rs4646536, or CYP2R1 rs10741657 single nucleotide polymorphisms. However, previous works presented inconsistent conclusions. Our study aimed at assessing the association of CYP27B1 and CYP2R1 polymorphisms with autoimmune endocrine disorder susceptibility using the meta-analysis method.

Methods
Case-control studies of the subject of interest were identified from the databases Pubmed, Embase, Cochrane Library, and China National Knowledge Infrastructure. Studies that met inclusion and quality criteria were pooled. Observational outcomes were diagnosis of autoimmune Addison’s disease, Graves disease, Hashimoto thyroiditis, or type 1 diabetes mellitus. Statistical analysis was performed using software STATA 16.0.

Results
A total of 14 studies involving 12 929 patients (2243 autoimmune Addison disease, 1253 Graves disease, 612 Hashimoto thyroiditis, 8821 type 1 diabetes), and 12 907 healthy control subjects were pooled for meta-analysis. The rs10877012 minor allele A and its homozygote and heterozygote conferred low overall disease risk (OR [odds ratio] = 0.748, 95% CI [confidence interval] 0.620-0.902 in dominant model; OR = 0.709, 95% CI 0.571-0.879 in recessive model; OR = 0.777, 95% CI 0.674-0.895 in the allele model). The population carrying rs4646536 minor allele C and its homozygote and heterozygote showed decreased overall autoimmune endocrine disorders risk (OR = 0.849, 95% CI 0.748-0.963; OR = 0.868, 95% CI 0.790-0.955; OR = 0.915, 95% CI 0.875-0.957 in the dominant, recessive, and allele model, respectively). No significant genetic association was found for rs10741657.

Conclusion
Our study suggested CYP27B1 polymorphisms rs10877012 minor allele A and rs4646536 minor allele C were negatively related to susceptibilities of organ-specific autoimmune endocrine diseases.
Maintenance of Acromegaly Control in Patients Switching From Injectable Somatostatin Receptor Ligands to Oral Octreotide
Authors: Samson Susan L , Nachtigall Lisa B , Fleseriu Maria , Gordon Murray B , Bolanowski Marek , Labadzhyan Artak , Ur Ehud , Molitch Mark , Ludlam William H , Patou Gary , Haviv Asi , Biermasz Nienke , Giustina Andrea , Trainer Peter J , Strasburger Christian J , Kennedy Laurence , Melmed Shlomo 
Published: August 2020

Abstract

Purpose
The phase 3 CHIASMA OPTIMAL trial (NCT03252353) evaluated efficacy and safety of oral octreotide capsules (OOCs) in patients with acromegaly who previously demonstrated biochemical control while receiving injectable somatostatin receptor ligands (SRLs).

Methods
In this double-blind study, patients (N = 56) stratified by prior SRL dose were randomly assigned 1:1 to OOC or placebo for 36 weeks. The primary end point was maintenance of biochemical control at the end of treatment (mean insulin-like growth factor 1 [IGF-1] ≤ 1.0 × upper limit of normal [ULN]; weeks 34 and 36). Time to loss of IGF-1 response and proportion requiring reversion to injectable SRLs were assessed as broader control measures.

Results
Mean IGF-1 measurements were 0.80 and 0.97 × ULN for OOC and 0.84 and 1.69 × ULN for placebo, at baseline and end of treatment, respectively. Mean growth hormone (GH) changed from 0.66 to 0.60 ng/mL for OOCs and 0.90 to 2.57 ng/mL for placebo. Normalization of IGF-1 levels (≤ 1.0 × ULN) was maintained in 58.2% for OOCs vs 19.4% for placebo (P = .008); GH levels were maintained (&lt; 2.5 ng/mL) in 77.7% for OOC vs 30.4% for placebo (P = .0007). Median time to loss of response (IGF-1 &gt; 1.0 or ≥ 1.3 × ULN definitions) for patients receiving placebo was 16 weeks; for patients receiving OOCs, it was not reached for both definitions during the 36-week trial (P &lt; .0001). Of the patients in the OOC group, 75% completed the trial on oral therapy. The OOC safety profile was consistent with previous SRL experience.

Conclusions
OOCs may be an effective therapy for patients with acromegaly who previously were treated with injectable SRLs.
A Field-based Three-Compartment Model Derived from Ultrasonography and Bioimpedance for Estimating Body Composition Changes
Authors: TINSLEY GRANT M. , RODRIGUEZ CHRISTIAN , WHITE SARAH J. , WILLIAMS ABEGALE D. , STRATTON MATTHEW T. , HARTY PATRICK S. , SMITH ROBERT W. , DELLINGER JACOB R. , JOHNSON BAYLOR A. 
Published: August 2020

ABSTRACT

Purpose
The purpose of this study was to assess the agreement between a field-based three-compartment (3CFIELD) model and a laboratory-based three-compartment (3CLAB) model for tracking body composition changes over time.

Methods
Resistance-trained males completed a supervised nutrition and resistance training intervention. Before and after the intervention, assessments were performed via air displacement plethysmography (ADP), bioimpedance spectroscopy (BIS), portable ultrasonography (US), and bioelectrical impedance analysis (BIA). ADP body density and BIS body water were used within the reference 3CLAB model, whereas US-derived body density and BIA body water were used within the 3CFIELD model. Two-compartment model body composition estimates provided by US and BIA were also examined. Changes in fat-free mass and fat mass were analyzed using repeated-measures ANOVA, equivalence testing, Bland–Altman analysis, linear regression, and related validity analyses.

Results
Significant increases in fat-free mass (3CLAB, 4.0 ± 4.5 kg; 3CFIELD, 3.9 ± 4.2 kg; US, 3.2 ± 4.3 kg; BIA, 3.9 ± 4.2 kg) and fat mass (3CLAB, 1.3 ± 2.2 kg; 3CFIELD, 1.4 ± 2.2 kg; US, 2.1 ± 2.6 kg; BIA, 1.4 ± 2.9 kg) were detected by all methods. However, only the 3CFIELD model demonstrated equivalence with the 3CLAB model. In addition, the 3CFIELD model exhibited superior performance to US and BIA individually, as indicated by the total error (3CFIELD, 1.0 kg; US, 1.8 kg; BIA, 1.6 kg), 95% limits of agreement (3CFIELD, ±2.1 kg; US, ±3.3 kg; BIA, ±3.1 kg), correlation coefficients (3CFIELD, 0.79–0.82; US, 0.49–0.55; BIA, 0.61–0.72), and additional metrics.

Conclusions
The present study demonstrated the potential usefulness of a 3CFIELD model incorporating US and BIA data for tracking body composition changes over time, as well as its superiority to US or BIA individually. As such, this accessible multicompartment model may be suitable for implementation in field or limited-resource settings.
Comparison of pain assessments made by patients and nurses in emergency services
Authors: Sucu Çakmak Nefise Cevriye , Çalışkan Nurcan 
Published: August 2020

Aim: This research aimed to compare pain assessments made by patients and by nurses.
Method: This descriptive and comparative research was conducted in a state, a university and a private hospital emergency service monitoring unit that had the highest number of patient admissions in Ankara, Turkey. The research sample consisted of 175 patients and 35 nurses. For the collection of data, the following sources were consulted: the patient information form, the nurse information form and the McGill Pain Questionnaire. For evaluation of the data, number and percentage calculations, chi-square analysis, kappa compliance analysis and the Wilcoxon sign test were used. Written consent was received from the ethical council and hospitals as well as from nurses and patients.
Results: 74.3% of nurses stated that they do not think that the pain level expressed by the patient is always right. While the point average given by patients related to all dimensions define the characteristics of pain was 20.48 ± 10.10, the average given by nurses was 14.35 ± 8.46. There is a statistically significant difference between the point averages given by patients and nurses related to total dimensions of pain characteristics (p<0.05).
Conclusion: As a result, pain evaluations of nurses were found to be significantly lower than those of patients. It is suggested that the policies and procedures used in health personnel education institutes and health institutes related to pain management should be improved.
Maize Introgression Library Provides Evidence for the Involvement ofliguleless1in Resistance to Northern Leaf Blight
Authors: Kolkman Judith M , Strable Josh , Harline Kate , Kroon Dallas E , Wiesner-Hanks Tyr , Bradbury Peter J , Nelson Rebecca J 
Published: August 2020

AbstractPlant disease resistance is largely governed by complex genetic architecture. In maize, few disease resistance loci have been characterized. Near-isogenic lines are a powerful genetic tool to dissect quantitative trait loci. We analyzed an introgression library of maize (Zea mays) near-isogenic lines, termed a nested near-isogenic line library for resistance to northern leaf blight caused by the fungal pathogen Setosphaeria turcica. The population was comprised of 412 BC5F4 near-isogenic lines that originated from 18 diverse donor parents and a common recurrent parent, B73. Single nucleotide polymorphisms identified through genotyping by sequencing were used to define introgressions and for association analysis. Near-isogenic lines that conferred resistance and susceptibility to northern leaf blight were comprised of introgressions that overlapped known northern leaf blight quantitative trait loci. Genome-wide association analysis and stepwise regression further resolved five quantitative trait loci regions, and implicated several candidate genes, including Liguleless1, a key determinant of leaf architecture in cereals. Two independently-derived mutant alleles of liguleless1 inoculated with S. turcica showed enhanced susceptibility to northern leaf blight. In the maize nested association mapping population, leaf angle was positively correlated with resistance to northern leaf blight in five recombinant inbred line populations, and negatively correlated with northern leaf blight in four recombinant inbred line populations. This study demonstrates the power of an introgression library combined with high density marker coverage to resolve quantitative trait loci. Furthermore, the role of liguleless1 in leaf architecture and in resistance to northern leaf blight has important applications in crop improvement.