bluuebunny/crossref_metadata_2025_split huggingface dataset:
O historiador com CNPJ: depressão, mercado de trabalho e história pública
Authors: Telles da Silveira Pedro 
Published: August 2020

Historiadoras e historiadores têm enfrentado uma nova série de tensões na tentativa de justificar o trabalho que realizam. Projetos legislativos, discursos políticos, cortes no financiamento de instituições públicas e privadas, todos eles originam uma situação cada vez mais dificultosa para a prática acadêmica. Não por acaso, os casos de depressão e problemas psicológicos na graduação e pós-graduação começaram a ganhar destaque no debate público. Ao mesmo tempo, temos visto também o crescimento da preocupação com a maneira pela qual historiadoras e historiadores podem legitimar perante a sociedade o que fazem. Uma dessas maneiras é a história pública. A partir dessa situação, o objetivo desta contribuição é defender a necessidade de uma discussão mais ampla sobre trabalho e relações trabalhistas no âmbito da história. Assim, propõe-se que os cursos de graduação e pós-graduação em história assumam postura ativa e, até mesmo, propositiva frente ao mercado de trabalho, através da reconfiguração da identidade profissional de historiadoras e historiadores que a história pública oferece. Dessa maneira, considera-se que a história pública tem papel fundamental para encontrar brechas que permitam superar o diagnóstico concomitante do aumento dos casos de depressão e ausência de perspectivas profissionais, de modo a repensar o que as historiadoras e historiadores fazem. Palavras-chave: História Pública. Mercado de Trabalho. Depressão Mental.
Le metteur en scène et les autres ou de la difficulté du partage de l’auctorialité dans le théâtre public français
Authors: Hamidi-Kim Bérénice 
Published: August 2020

Cet article vise à élucider tout à la fois les causes et les conséquences d’un paradoxe caractéristique du monde du spectacle vivant subventionné en France : alors que les oeuvres scéniques ont pour particularité, par rapport à d’autres mondes de l’art, de reposer sur le travail collectif d’une grande diversité de corps de métiers, artistiques et techniques, la reconnaissance, tant symbolique qu’économique, est pour l’essentiel captée par la figure, souvent individuelle, du metteur en scène, et ce processus de captation passe principalement par la transfiguration de la figure du metteur en scène en auteur du spectacle.
Ultrasound Shear Wave Elastography to Assess Tissue Mechanical Properties in Somatic Dysfunction: A Feasibility Study
Authors: Gao Jing , Caldwell Judy , Wells Michael , Park David 
Published: August 2020

Abstract

Context
Diagnosis of somatic dysfunction is based on subjective palpatory osteopathic assessments. This subjectivity has posed a challenge for researchers in studying osteopathic medicine. The development and use of radiological imaging techniques to objectively confirm or quantify muscle tissue stiffness associated with somatic dysfunction could be of benefit in osteopathic clinical practice, training, and further research.

Objectives
To investigate the feasibility of ultrasound shear wave elastography (SWE) to quantify muscle tissue stiffness in somatic dysfunction before and after osteopathic manipulative treatment (OMT).

Methods
In this prospective study, we assessed lumbar spine somatic dysfunction in 20 adult patients before and after a single OMT session using standard osteopathic palpatory assessments by osteopathic physician faculty members in the Department of Osteopathic Principle and Practice at Rocky Vista University College of Osteopathic Medicine (Utah campus). Shear wave velocity (SWV, m/s) was measured in lumbar paraspinal muscle tissue using a commercial ultrasonography scanner on all participants immediately before and after OMT. In this study, OMT techniques targeted the iliocostalis lumborum and included the articulatory technique, balanced ligamentous tension, facilitated positional release, high-velocity, low-amplitude technique, muscle energy, myofascial release, and the Still technique at the discretion of the osteopathic physician. The difference in SWV between muscle tissues with and without dysfunction, and differences in SWV of dysfunctional tissue before and after OMT were examined using unpaired and paired t tests, as appropriate. The correlation between SWV measurements and osteopathic assessments was examined by the Spearman rank correlation. Intra- and interobserver reliability was analyzed using intraclass correlation coefficient.

Results
The difference in SWV between muscle tissues with and without somatic dysfunction was significant before OMT (mean [SD], 1.93 [0.44] vs 1.69 [0.19]; P=.03) and was not significant after OMT (mean [SD], 1.69 [0.19] vs 1.53 [0.31]; P=.05). The difference in SWV in the same tissue with somatic dysfunction before and after OMT was significant (mean [SD], 1.93 [0.44] vs 1.52 [0.3]; P<.001). The SWV value highly correlated with manual osteopathic assessments (r=0.72). Intra- and interobserver reliability for performing SWE in somatic dysfunction was good (intraclass correlation coefficient >0.80).

Conclusions
The results of this study show that ultrasound SWE can objectively assess muscle tissue stiffness for diagnosis of somatic dysfunctions and for muscle tissue stiffness changes after OMT.
Downregulation of STK4 promotes colon cancer invasion/migration through blocking β‐catenin degradation
Authors: Lin Cheng‐Han , Hsu Tai‐I , Chiou Pei‐Yu , Hsiao Michael , Wang Wen‐Ching , Chen Yu‐Chia , Lin Jen‐Tai , Wang Jaw‐Yuan , Lin Peng‐Chan , Lin Forn‐Chia , Tseng Yu‐Kai , Cheng Hui‐Chuan , Chen Chi‐Long , Lu Pei‐Jung 
Published: August 2020

Mammalian STE20‐like kinase 1 (MST1/STK4/KRS2) encodes a serine/threonine kinase that is the mammalian homolog of Drosophila Hippo. STK4 plays an important role in controlling cell growth, apoptosis, and organ size. STK4 has been studied in many cancers with previous studies indicating an involvement in colon cancer lymph node metastasis and highlighting its potential as a diagnostic marker for colon cancer. However, the role of STK4 defect in promoting colon cancer progression is still understudied. Here, we found that STK4 was significantly downregulated in colon cancer and was associated with distal metastasis and poor survival. Furthermore, STK4 knockdown enhanced sphere formation and metastasis in vitro and promoted tumor development in vivo. We found that STK4 colocalized with β‐catenin and directly phosphorylated β‐catenin resulting in its degradation via the ubiquitin‐mediated pathway. This may suggest that STK4 knockdown causes β‐catenin phosphorylation failure and subsequently β‐catenin accumulation, consequently leading to anchorage‐independent growth and metastasis in colon cancer. Our results support that STK4 may act as a potential candidate for the assessment of β‐catenin‐mediated colon cancer prognosis.
Chemokine‐like factor 1 (CKLF1) aggravates neointimal hyperplasia through activating the NF‐κB /VCAM‐1 pathway
Authors: Liu Xinnong , Qu Chengjia , Zhang Yongbao , Fang Jie , Teng Lequn , Zhang Rujiao , Zhang Xiangyu , Shen Chenyang 
Published: August 2020

Neointimal hyperplasia (NIH) is a complicated inflammatory process contributing to vascular restenosis. The present study aimed to explore whether chemokine‐like factor 1 (CKLF1) aggravates NIH via the nuclear factor‐kappa B (NF‐κB)/vascular cell adhesion molecule‐1 (VCAM‐1) pathway. We found the expression of CKLF1 and VCAM‐1 significantly increased in human carotid plaques compared to the control. In vivo, CKLF1 overexpression induced a thicker neointimal formation and VCAM‐1 expression was correspondingly upregulated. In vitro, CKLF1 activated NF‐κB and induced VCAM‐1 upregulation in human aortic smooth muscle cells (HASMCs). Functional experiments demonstrated that CKLF1 promoted monocyte adhesion and HASMC migration via VCAM‐1. These results suggest CKLF1 accelerates NIH by promoting monocyte adhesion and HASMC migration via the NF‐κB/VCAM‐1 pathway. Our findings contribute to a better understanding of the mechanisms underlying the causality of CKLF1 on NIH and could prove beneficial in designing therapeutic modalities with a focus on CKLF1.
Determination of machine‐specific tolerances using statistical process control analysis of long‐term uniform scanning proton machine QA results
Authors: Rana Suresh , Eckert Colton , Singh Hardev , Zheng Yuanshui , Chacko Michael , Storey Mark , Chang John 
Published: August 2020

AbstractPurposeThe purpose of this study was twofold: (a) report the long‐term monthly quality assurance (QA) dosimetry results of the uniform scanning beam delivery system, and (b) derive the machine‐specific tolerances based on the statistic process control (SPC) methodology and compare them against the AAPM TG224 recommended tolerances.MethodsThe Oklahoma Proton Center has four treatment rooms (TR1, TR2, TR3, and TR4) with a cyclotron and a universal nozzle. Monthly QA dosimetry results of four treatment rooms over a period of 6 yr (Feb 2014–Jan 2020) were retrieved from the QA database. The dosimetry parameters included dose output, range, flatness, and symmetry. The monthly QA results were analyzed using the SPC method, which included individuals and moving range (I‐MR) chart. The upper control limit (UCL) and lower control limit (LCL) were set at 3σ above and below the mean value, respectively.ResultsThe mean difference in dose output was −0.3% (2σ = ±0.9% and 3σ = ±1.3%) in TR1, 0% (2σ = ±1.4% and 3σ = ±2.1%) in TR2, −0.2% (2σ = ±1.0% and 3σ = ±1.6%) in TR3, and −0.5% (2σ = ±0.9% and 3σ = ±1.3%) in TR4. The mean flatness and symmetry differences of all beams among the four treatment rooms were within ±1.0%. The 3σ for the flatness difference ranged from ±0.5% to ±1.2%. The 3σ for the symmetry difference ranged from ±0.4% to ±1.4%. The SPC analysis showed that the 3σ for range 10 cm (R10), R16, and R22 were within ±1 mm, whereas the 3σ for R28 exceeded ±1 mm in two rooms (3σ = ±1.9 mm in TR2 and 3σ = ±1.3 mm in TR3).ConclusionThe 3σ of the dose output, flatness, and symmetry differences in all four rooms were comparable to the TG224 tolerance (±2%). For the uniform scanning system, if the measured range is compared against the requested range, it may not always be possible to achieve the range difference within ±1 mm (TG224) for all the ranges.
Source Handler telephone interactions with covert human intelligence sources: An exploration of question types and intelligence yield
Authors: Nunan Jordan , Stanier Ian , Milne Rebecca , Shawyer Andrea , Walsh Dave 
Published: August 2020

SummaryLaw Enforcement Agencies gather intelligence in order to prevent criminal activity and pursue criminals. In the context of human intelligence collection, intelligence elicitation relies heavily upon the deployment of appropriate evidence‐based interviewing techniques (a topic rarely covered in the extant research literature). The present research gained unprecedented access to audio recorded telephone interactions (N = 105) between Source Handlers and Covert Human Intelligence Sources (CHIS) from England and Wales. The research explored the mean use of various question types per interaction and across all questions asked in the sample, as well as comparing the intelligence yield for appropriate and inappropriate questions. Source Handlers were found to utilise vastly more appropriate questions than inappropriate questions, though they rarely used open‐ended questions. Across the total interactions, appropriate questions (by far) were associated with the gathering of much of the total intelligence yield. Implications for practise are discussed.
Association Between Specimen Length and Number of Sections and Diagnostic Yield of Temporal Artery Biopsy for Giant Cell Arteritis
Authors: Muratore Francesco , Boiardi Luigi , Cavazza Alberto , Tiengo Giacomo , Galli Elena , Aldigeri Raffaella , Pipitone Nicolò , Cimino Luca , Bonacini Martina , Croci Stefania , Salvarani Carlo 
Published: August 2020

ObjectiveTo investigate the association between specimen length and number of sections evaluated and the diagnostic yield of temporal artery biopsy (TAB) for giant cell arteritis (GCA).MethodsA pathologist reviewed all TABs performed for suspected GCA between January 1991 and December 2012. The blocks of all the inadequate and negative biopsy specimens were recut, and further slides at deeper levels were stained with hematoxylin and eosin in order to avoid missing inflammatory changes.ResultsIn total, findings from 662 TABs were included in the study (71% female; mean age 73.2 years). A total of 427 TAB specimens (65%) were classified as negative, and 235 (35%) were classified as positive for GCA. Compared to those with negative TAB results, patients with positive TAB results were older and more frequently female. There was no difference in postfixation TAB specimen length between TAB specimens negative and positive for GCA (mean 6.5 mm versus 6.9 mm; P = 0.068). Cuts of additional biopsy sections revealed inflammation at deeper levels in 26 of 408 TAB specimens (6.4%) originally reported as uninflamed. The inflamed section was the second in 14 TAB specimens, the third in 9 specimens, and the fourth in 3 specimens. Piecewise logistic regression identified 5 mm as the TAB specimen length change point for diagnostic sensitivity. Compared to a TAB specimen length of <5 mm, the age‐ and sex‐adjusted odds ratio for positive TAB results in samples ≥5 mm long was 1.5 (95% confidence interval 1.0–2.0), P = 0.032.ConclusionA postfixation TAB specimen length of at least 5 mm should be sufficient to make a histologic diagnosis of GCA. In order not to miss inflammatory changes, at least 3 further sections at deeper levels should be evaluated in all negative TAB specimens.
Cachexia in Systemic Lupus Erythematosus: Risk Factors and Relation to Disease Activity and Damage
Authors: Stojan George , Li Jessica , Wittmaack Amaya , Petri Michelle 
Published: August 2020

ObjectiveCachexia is a disorder characterized by involuntary weight loss in addition to loss of homeostatic control of both energy and protein balance. Despite an abundance of data from other inflammatory diseases, cachexia in systemic lupus erythematosus (SLE) remains a largely undescribed syndrome. The present study was undertaken to define the prevalence of cachexia in SLE and to identify the main factors that place patients at risk of developing cachexia.MethodsA total of 2,452 patients in a prospective SLE cohort had their weight assessed at each visit. Patients were categorized into 5 predetermined groups based on weight. Cachexia was defined based on modified Fearon criteria (5% stable weight loss in 6 months without starvation relative to the average weight in all prior visits and/or a weight loss of >2% without starvation relative to the average weight in all prior cohort visits and a body mass index [BMI] of <20 kg/m2). Risk of cachexia within 5 years of cohort entry was based on Kaplan‐Meier estimates. The association of prior disease manifestations with risk of cachexia adjusted by current steroid use was determined using Cox regression. An analysis of variance test was used to determine whether Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) scores varied based on cachexia status.ResultsWithin 5 years of cohort entry, 56% of patients developed cachexia, 18% of which never recovered their weight during follow‐up. The risk factors for cachexia development were a BMI of <20 kg/m2, current steroid use, vasculitis, lupus nephritis, serositis, hematologic lupus manifestations, positive anti–double‐stranded DNA, anti‐Sm, and anti‐RNP. Patients with intermittent cachexia had significantly higher SDI scores compared to those with continuous cachexia or without cachexia.ConclusionCachexia is an underrecognized syndrome in patients with SLE. SLE patients with intermittent cachexia have the highest risk of future organ damage.
Patterns and Correlates of Self‐Management Strategies for Osteoarthritis‐Related Pain Among Older Non‐Hispanic Black and Non‐Hispanic White Adults
Authors: Johnson Alisa J. , Sibille Kimberly T. , Cardoso Josue , Terry Ellen L. , Powell‐Roach Keesha L. , Goodin Burel , Staud Roland , Redden David , Fillingim Roger B. , Booker Staja Q. 
Published: August 2020

ObjectiveKnee osteoarthritis (OA) is a leading source of pain and disability among older adults. Self‐management (SM) strategies are recommended to manage OA symptoms. Sociodemographic and clinical characteristics, along with other factors, may influence SM utilization rate. This study sought to examine the prevalence and correlates of SM use for pain among non‐Hispanic Black patients (NHB) and non‐Hispanic White patients (NHW) older adults with or at risk for knee OA.MethodsA secondary data analysis was conducted on the Understanding Pain and Limitations in Osteoarthritic Disease multisite observational study, which included NHB (n = 104) and NHW (n = 98) community‐dwelling older adults with or at risk for knee OA. Participants completed measures of sociodemographics, pain SM use, coping, and clinical and experimental pain.ResultsClinical and experimental pain were significantly greater among NHBs compared to NHWs. There were no significant differences in use of total SM by ethnicity/race. Interestingly, multiple linear regression revealed that clinical and experimental pain indices, as well as coping, number of pain sites, age, and sex were differentially associated with total SM use between NHBs and NHWs. There were significant ethnicity/race by type of pain management interaction effects for pain measures.ConclusionSM is common among older adults with or at risk for knee OA pain, and the prevalence of SM does not differ by ethnicity/race, but many guideline‐recommended interventions for OA are underutilized. Importantly, different factors were associated with the use of SM, highlighting distinct biopsychosocial mechanisms contributing to SM use in NHBs and NHWs.
Major Depression and Adverse Patient‐Reported Outcomes in Systemic Lupus Erythematosus: Results From a Prospective Longitudinal Cohort
Authors: Dietz Brett , Katz Patricia , Dall’Era Maria , Murphy Louise B. , Lanata Cristina , Trupin Laura , Criswell Lindsey A. , Yazdany Jinoos 
Published: August 2020

ObjectiveHealth‐related quality of life (HRQoL) is reduced in systemic lupus erythematosus (SLE), partly driven by comorbid depression. Among patients with SLE, the association between major depression and HRQoL, measured using the NIH’s Patient‐Reported Outcomes Measurement Information System (PROMIS), is not well characterized. The objective was to determine an association between major depression and HRQoL as measured by PROMIS.MethodsCross‐sectional data were obtained from the California Lupus Epidemiology Study, a cohort of adults in the San Francisco Bay Area with SLE. We studied the association between major depression (score ≥10 on the Patient Health Questionnaire 8 depression scale) and T scores (scaled to population mean ± SD of 50 ± 10) on 12 PROMIS domains representing physical, mental, and social health. Mean T scores in depressed and nondepressed individuals were compared using multiple linear regression models adjusting for age, sex, race/ethnicity, disease activity, damage, body mass index, and household income.ResultsMean age of the 326 participants was 45 years; ~89% were women, 29% White, 23% Hispanic, 10% African American, and 36% Asian. One‐fourth met the criteria for major depression. In multivariable analyses, major depression was independently associated with worse T scores on all 12 PROMIS domains (P < 0.001); compared with those without major depression, depressed individuals scored >10 points (1 SD) worse on fatigue, sleep impairment, negative psychosocial impact of illness, satisfaction in discretionary social activities, and satisfaction in social roles.ConclusionIn individuals with SLE, major depression is associated with markedly worse PROMIS scores in physical, mental, and social domains. Diagnosing and treating depression may help improve HRQoL in individuals with SLE.
Associations Between Cadence and Knee Loading in Patients With Knee Osteoarthritis
Authors: Hart Harvi F. , Birmingham Trevor B. , Primeau Codie A. , Pinto Ryan , Leitch Kristyn , Giffin J. Robert 
Published: August 2020

ObjectiveTo test the hypothesis that higher walking cadence is associated with lower knee loading, while controlling for walking speed, in patients with medial compartment tibiofemoral osteoarthritis (OA).MethodsA total of 691 patients underwent quantitative gait analysis, including 3‐dimensional knee moments and temporospatial parameters. Using multivariate linear regression, we tested the association of walking cadence with the knee adduction moment angular impulse (a surrogate measure of medial knee compartment load throughout the stance), while controlling for walking speed. We repeated the analysis while also adjusting for sex, age, body mass index, radiographic OA, knee pain, lateral trunk lean, foot progression angle, and mechanical axis angle, and while replacing the knee adduction moment angular impulse with other surrogate measures of knee loading.ResultsWhile controlling for walking speed, we found that a lower cadence was associated with higher knee adduction moment angular impulse (standardized β = –0.396, P < 0.001), suggesting a 0.02% body weight × height × seconds (%BW × Ht × s) decrease in impulse for each step per minute increase in cadence (unstandardized β –0.020 %BW × Ht × s [95% confidence interval –0.027, –0.015]), and remained consistent after adjusting for covariates. A lower cadence was also associated with higher first (standardized β = –0.138, P = 0.010) and second peak knee adduction moment (standardized β = –0.132, P = 0.018), higher peak knee flexion moment (standardized β = –0.128, P = 0.049), and vertical ground reaction force (standardized β = –0.116, P = 0.035) in the adjusted analyses.ConclusionWhen controlling for walking speed, we found that a lower cadence is associated with higher knee loading per step in patients with medial tibiofemoral OA. Future research should investigate the potential beneficial biomechanical and clinical effects of increasing walking cadence in patients with knee OA.