bluuebunny/crossref_metadata_2025_split huggingface dataset:
Landscape Architecture and Framing to Psychological Well-Being in Schizophrenics
Authors: Chang Mei-Chung , Lung Pey , Lung For-Wey 
Published: August 2020

Abstract
Background: This study is to assess how the presence of landscape features influences the visit intention of users in different roles in a hospital setting. Method: Total of 94 patients with mental illness, including 71 schizophrenics and 23 borderline disorder who lived in a psychiatric hospital in southern Taiwan were recruited. Firstly, all participants were selected three pictures of hospital inside architecture design and another three outside landscape. Second, all of them need to choice each three favorite pictures from 12 of inside architecture design and 12 of outside landscape.Results: By structural equation modeling, patient who select card 8 in outside landscape, tend to better psychological well-being. Patients with higher level of emotional distress like to select card 10 in inside architecture design, then further reducing whose psychological well-being. In addition, who with higher level education like to select card 2 in inside architecture design, and then further increasing contributed to psychological well-being.Conclusions: There are several different outcomes to sex, education, diagnosis, mental illness, social adaption status, and psychological well-being in the effects of landscape architecture for patients with schizophrenia and borderline. Different individuals with different diagnosis mental symptoms, and psychological well-being have different preferences in landscape, but it just be a state of “here and now”. Hence, the longitudinal follow-up study should be consider in further studies. Moreover, the effects of landscape architecture how to play the role in the treatment of mental diseases and its clinical implication also need to consider in the future comprehensive studies.
Is routine X-ray pelvimetry of value to decide on mode of delivery for women with labor dystocia?
Authors: Kawakami Kaori , Tanaka Yuria , Ikeda Yuji , Komatsu Atsushi , Kobayashi Osamu , Nakajima Takahiro , Nakao Takehiro , Takeya Chiaki , Asai-Sato Mikiko , Chishima Fumihisa , Iwata Misako , Kawana Kei 
Published: August 2020

Abstract
Background: X-ray pelvimetry is used for evaluation of pelvic inlet generally to diagnose cephalopelvic disproportion (CPD) or contracted inlet. Cesarean section delivery (C/S) is often performed for labor dystocia without CPD or contracted inlet. Here, we examined whether X-ray pelvimetry is useful to decide on mode of delivery in women with dystocia.Method: A total of 1118 pregnant women received X-ray pelvimetry before or during labor. Overall, 205 women with cesarean deliveries for indications except for dystocia were excluded. The remaining 913 women undergoing induction/augmentation were retrospectively investigated. Obstetrical and maternal variables were analyzed by univariate, multivariate or ROC analysis.Results: Among 913 women, 37 (4%), including three with contracted inlet and seven with CPD, gave birth by C/S, whereas 876 gave birth by vaginal delivery. Low maternal height, older age, small obstetrical conjugate, large weight and infant head size were significantly associated with risk of C/S for dystocia. Multivariate analysis revealed that the obstetrical conjugate was an independent variable for risk of C/S. The area under the ROC curve (AUC) and the optimal cut-off values, respectively, were as follows: obstetrical conjugate: 0.68 and 11.7 cm (odds ratio=4.27), transverse diameter: 0.59 and 11.4 cm (odds ratio=1.82), maternal height: 0.70 and 155.5 cm (odds ratio=4.33), and maternal weight before pregnancy: 0.55 and 49.7 kg (odds ratio=1.98).Conclusion: The obstetrical conjugate was an independent variable associated with risk of C/S for dystocia. Additionally, maternal height was comparable to the conjugate in term of diagnostic ability. Our data suggested that routine X-ray pelvimetry was not beneficial to identify women at risk of C/S for dystocia.
Genome-wide identification and expression analysis of tomato ADK gene family during development and stress
Authors: Yang Lu , Cao Haohao , Zhang Xiaoping , Gui Liangxian , Chen Qiang , Qian Gui , Xiao Jiaxin , Li Zhengguo 
Published: August 2020

Abstract
Background: Adenylate kinase (ADK) is widely distributed in organisms and plays an important role in cellular energy homeostasis. In plants, ADK has important functions in plant growth and development regulation as well as adaptation to the environment. However, little information is available about the ADK genes in tomato (Solanum lycopersicum), an important economic crop.Results: To investigate the characteristics and functions of ADK genes in tomato, a total of 11 ADK genes were identified and named according to their chromosomal locations. The ADK family was divided into five groups and motif analysis revealed that each SlADK protein contained five to eight conserved motifs. Sequence analysis revealed 4-19 exons in all SlADKs and most members possessed four. The 11 SlADKs were randomly distributed on nine of the 12 tomato chromosomes. A cis-element analysis inferred that several stress response elements were found on the promoters of SlADKs. The online TomExpress platform prediction revealed that SlADKs were expressed in various tissues and organs, basically consistent with the data obtained from real-time quantitative PCR (qPCR). The qPCR verification was also used to determine the expression level of SlADKs and demonstrated that the genes responded to multiple abiotic stresses, such as drought, salt and cold. For example, almost all SlADKs contained two expression peaks at 9 and 48 h following salt treatment. The qPCR results showed that SlADK transcription was responsive to most of the applied hormone treatment: methyl jasmonate, ethylene, salicylic acid, indole 3-acetic acid and abscisic acid. Notably, SlADK2 and 4 exhibited significant changes under multiple stress treatments.Conclusions: These results provide valuable information for clarifying the evolutionary relationship of the tomato ADK family and in aiding functional characterization of SlADKs in further research.
Dissociation between 2-[18F]fluoro-2-deoxy-D-glucose Positron Emission Computer Tomography, Ultrasound and Clinical Assessments in Patients with non-severe Rheumatoid Arthritis including Remission
Authors: Rinkin Charline , Fosse Pacôme , Malaise Olivier , Chapelier Nathalie , Horrion Jil , Seidel Laurence , Adelin Albert , Hustinx Roland , Malaise Michel G. 
Published: August 2020

Abstract
Background: 2-[18F]fluoro-2-deoxy-D-glucose Positron Emission Computer Tomography ([18F]FDG PET/CT) in rheumatoid arthritis (RA) visualizes and quantifies inflammation in joints of patients with severe disease activity but little is known on the metabolic status and its relationship with clinical and ultrasonography (US) metrology in patients with low/moderate activity or in remission.Methods: Clinical assessments (DAS28-CRP, CDAI), [18F]FDG PET/CT, US and X-ray were performed on 63 RA patients classified into remission, low/moderate or severe disease activity. PET/CT was analyzed visually, then semi-quantitatively by determining standardized uptake value (SUV) of positive joints. Results: Of the 1764 joints, 21.1% were tender only, 13.7% swollen only, 27.6% tender or swollen, 7.3% tender and swollen, 20.5% PET/CT-positive and 8.6% US-positive. PET and US-measurements correlated, albeit with poor concordance. Positive predictive value of PET/CT for clinical evaluation (tender and/or swollen) was low whereas its negative predictive value was high. Highly significant differences were found in the number of PET/CT-positive joints and in cumulative SUV between “severe and non-severe cases” (including remission and low/moderate activity together) only, but not between “remission and non-remission” or “remission and low/moderate activity”. Moreover, correlation between PET/CT measurements and clinical activity was positive only in CDAI severe disease group. In patients with remission or low/moderate activity, only 20-30% of joints were PET/CT-negative. In remission, PET/CT and US were positive in different joints and PET/CT-positive but US-negative joints mainly exhibited RA (38.1%) or normal (49.2%), and not osteoarthritis (12.7%), X-ray pattern.Conclusions: [18F]FDG PET/CT was effective at distinguishing patients with a severely active disease from the others. In non-severe RA, including remission, patients, PET/CT results disconnect from US and clinical observations. A longitudinal analysis is needed to explore the clinical relevance of such infra-clinical disease.
Moringa Oleifera Leaf Extracts Protect BMSC Osteogenic Induction Following Peroxidative Damage by Activating The PI3K/Akt /Foxo1 Pathway
Authors: Liu Meiling , Ding Haifeng , Wang Hongzhi , Wang Manfeng , Wu Xiaowei , Gan Lu , Cheng Luyang , Li Xianglu 
Published: August 2020

Abstract
Objective: We aimed to investigate the therapeutic effects of Moringa oleifera leaf extracts on osteogenic induction of rat bone marrow mesenchymal stem cells (BMSCs) following peroxidative damage and to explore the underlying mechanisms. Methods: Conditioned medium was used to induce osteogenic differentiation of BMSCs, which were treated with H2O2, Moringa oleifera leaf extracts-containing serum, or the phosphatidyl inositol-3 kinase (PI3K) inhibitor Wortmannin, alone or in combination. Cell viability was measured using the MTT assay. Cell cycle was assayed using flow cytometry. Expression levels of Akt, phosphorylated (p)Akt, Foxo1, and cleaved caspase-3 were analyzed using Western blot analysis. The mRNA levels of osteogenesis-associated genes, including alkaline phosphatase (ALP), collagen І, osteopontin (OPN), and Runx2, were detected using qRT-PCR. Reactive oxygen species (ROS) and malondialdehyde (MDA) levels, as well as superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), and ALP activity were detected using commercially available kits. Osteogenic differentiation capability was determined using alizarin red staining. Results: During osteogenic induction of rat BMSCs, H2O2 reduced cell viability and proliferation, inhibited osteogenesis, increased ROS and MDA levels, and decreased SOD and GSH-PX activity. H2O2 significantly reduced pAkt and Foxo1 expression, and increased cleaved caspase-3 levels in BMSCs. Additional treatments with Moringa oleifera leaf extracts partially reversed the H2O2-induced changes. Wortmannin partially attenuated the effects of Moringa oleifera leaf extracts on protein expression of Foxo1, pAkt, and cleaved caspase-3, as well as mRNA levels of osteogenesis-associated genes.Conclusion: Moringa oleifera leaf extracts ameliorate peroxidative damage and enhance osteogenic induction of rat BMSCs by activating the PI3K/Akt/Foxo1 pathway.
The Lack of an Association between Body Image Satisfaction and Self-Esteem in High School Students in Eastern Croatia: A Cross-Sectional Study
Authors: Bosnic Zvonimir , Miletic Maja , Volaric Nikola , Holik Dubravka , Volaric Mile , Majnaric Ljiljana Trtica 
Published: August 2020

Abstract
Introduction: The research objectives are to examine the degree of satisfaction of students in two high schools in Eastern Croatia, regarding their physical appearance and self-esteem based on their gender and type of school - Grammar school or Vocational school. Furthermore, it aims to determine the correlation between degree of satisfaction regarding physical appearance and self-esteem and examines the differences in socio-economic status among the students of the two schools.Methods: The study is designed as a cross-sectional research performed in the Secondary Health and Veterinary School and Grammar School in Vinkovci. The study includes 278 participants. The data were collected in three ways. First, by using a survey on socio-economic status of the participants. Second, a modified test consisting of fourteen questions was used to examine the level of body image satisfaction. Third, a test consisting of ten questions was used to examine the level of self-esteem. Results: Median age of participants is 18 years. The research established a linear correlation between the body image satisfaction and gender of the students in both schools. An association between level of body image satisfaction and self-esteem was not established. Conclusion: To conclude with, adolescents in this region of Croatia are not overly concerned about their physical appearance despite relatively decreased self-esteem. A lack of association between reduced self-esteem and self-assessment of appearance may also be a consequence of later sexual maturation and tradional development which promote the traditional values of family, youth life and marriage
Personalized Single-Cell Networks: A Framework to Predict The Response of Any Gene To Any Drug For Any Patient
Authors: Harikumar Haripriya , Quinn Thomas P , Rana Santu , Gupta Sunil , Venkatesh Svetha 
Published: August 2020

Abstract
Background: The last decade has seen a major increase in the availability of genomic data. This includes expert-curated databases that describe the biological activity of genes, as well as high-throughput assays that measure the gene expression of bulk tissue and single cells. Integrating these heterogeneous data sources can generate new hypotheses about biological systems. Our primary objective is to combine population-level drug-response data with patient-level single-cell expression data to predict how any gene will respond to any drug for any patient. Methods: We use a “dual-channel” random walk with restart algorithm to perform 3 analyses. First, we use glioblastoma single cells from 5 individual patients to discover genes whose functions differ between cancers. Second, we use drug screening data from the Library of Integrated Network-Based Cellular Signatures (LINCS) to show how a cell-specific drug-response signature can be accurately predicted from a baseline (drug-free) gene co-expression network. Finally, we combine both data streams to show how we can predict how any gene will respond to any drug for each of the 5 glioblastoma patients. Conclusions: Our manuscript introduces two innovations to the integration of heterogeneous biological data. First, we use a “dual-channel” method to predict up-regulation and down-regulation separately. Second, we use individualized single-cell gene co-expression networks to make personalized predictions. These innovations let us predict gene function and drug response for individual patients. When applied to real data, we identify a number of genes that exhibit a patient-specific drug response, including the pan-cancer oncogene EGFR.
Anesthesia Management in Patients With Central Airway Stenosis Undergoing Bronchoscopy Treatments - Safety Application of Muscle Relaxants and the Traditional Low-frequency Ventilation : A Retrospective Observational Study
Authors: Li Jing-Jin , Li Nan , Ma Wei-Jia , Bao Ming-Xue , Chen Zi-Yang , Ding Zheng-Nian 
Published: August 2020

Abstract
Background: Bronchoscopy treatments of central airway stenosis (CAO) under general anesthesia are high-risky procedures, and posing a giant challenge to the anesthesiologists. The aim of this research was to estimate the safety application of muscle relaxants and the traditional Low-frequency ventilation in patients with central airway stenosis undergoing bronchoscopy treatments under general anesthesia by summarizing our clinical experience.Methods: Clinical data of 375 patients with CAO who underwent urgent endoscopic treatments from January 2016 to October 2019 were retrospectively reviewed. The use ratio of skeletal muscle relaxants, dose of fentanyl and skeletal muscle relaxants used between rigid bronchoscopy compared with flexible bronchoscopy therapy, the incidence of perioperative adverse events, adequacy of ventilation and gas exchange, post-operative recovery and risk factors for postoperative ICU admission were evaluated. Results: There was a high usage rate (96.5%) of skeletal muscle relaxants in patients with CAO who underwent either flexible bronchoscopy or rigid bronchoscopy therapy and there is a higher dosage of analgesic and skeletal muscle relaxants used in rigid bronchoscopy compared with flexible bronchoscopy therapy. This procedure had a low incidence of perioperative adverse events, with no significant difference between flexible bronchoscopy and rigid bronchoscopy therapy. Sufficient ventilation was successfully established using the traditional Low-frequency ventilation both in flexible and rigid bronchoscopy group. There was a low mortality (0.8%) during the post-operative recovery, and the higher grade of ASA and obvious dyspnea or orthopnea were the independent risk factors for postoperative ICU admission. Conclusion: The use of proper dosage of muscle relaxants is indispensable and safe in patients with CAO undergoing bronchoscopy treatments and the traditional Low-frequency ventilation also can be used in this procedure safely.
Mapping and validation of quantitative trait loci that confer resistance to rice black-streaked dwarf virus disease in rice (Oryza sativa)
Authors: zhang honggen , Wang Ruixuan , Xu Zuopeng , Liu Jiangning , Lan Guofang , Chen Zhiai , Gu Minghong , Tang Shuzhu 
Published: August 2020

Abstract
Background: Rice black-streaked dwarf virus (RBSDV) disease is one of the most destructive viral diseases that threatens rice production in China. Breeding of resistant cultivars through multi-gene pyramiding is considered to be an effective way to control the disease, but few resistance genes have been characterized to date.Results; In the present study, we identified T1012, a BC2F6 line from a cross of the japonica variety ‘Wuyujing3’ (recipient) and the indica variety ‘Dular’ (donor), that had improved resistance to RBSDV disease in a field test, and 140 chromosome segment substitution lines (CSSLs) derived from a cross of between T1012 and ‘Wuyujing3’ were developed using marker-assisted selection. Genetic analysis showed that the resistance of T1012 to RBSDV disease was controlled by quantitative trait loci (QTLs). Two QTLs for RBSDV disease resistance located on chromosomes 1 and 4, qRBSDV-1 and qRBSDV-4, were identified, and qRBSDV-4 was repeatedly detected in two environments. Compared to ‘Wuyujing3’, the CSSL containing only the substitution segment covering qRBSDV-4 exhibited significantly decreased disease incidence, indicating that qRBSDV-4 is a reliable resistance QTL with a high breeding value. Furthermore, two linked QTLs, qRBSDV-4-1 and qRBSDV-4-2, were identified within the interval containing qRBSDV-4.Conclusions: The QTLs identified here will provide a useful resource for breeding RBSDV-resistant rice cultivars through marker-assisted selection and establish a foundation for the cloning of RBSDV disease resistance genes.
Total Knee Arthroplasty in Patients with Rheumatoid Arthritis, Severe Osteoporosis, and Genu Valgum
Authors: Zhang Tao , Zhou Yong , Zhang Rui , Li Mi , Zhang Dapeng , Hu Naiwu 
Published: August 2020

Abstract
Background: Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by symmetric, relapsing, or chronic destructive synovitis. The aim of this retrospective study was to assess the clinical benefits of TKA in patients with severe osteoporosis and moderate genu valgum.Methods: This was a retrospective study of patients with RA, osteoporosis, and genu valgus treated using TKA at the Fourth Affiliated Hospital of Harbin Medical University between 05/2016 and 05/2019. Posterior stable prostheses were used in all patients. The Knee Society Scoring System (KSS) was used.Results: There were eight males with 10 knees involved and 24 females with 34 knees involved. Healing by first intention was achieved in all patients. All patients received follow-up, with the mean follow up time of 2.9 (1-4) years. At the last follow-up, the KSS clinical score was improved from 32.1±9.8 to 82.0±5.8, (P<0.001). The KSS functional score of the patients was improved from 38.3±9.3 to 88.1±10.7 (P<0.001). The flexion-extension ROM of the knee joint was improved from 81.8°±27.9° to 105.8°±17.0° (P<0.001). The femorotibial angle (FTA) was changed from 23.1°±2.8° to 6.8°±1.9° (P<0.001). Common peroneal nerve paralysis and periarticular infection each occurred in one patient.Conclusion: TKA via the medial parapatellar approach with proper osteotomy and soft tissue balancing could restore the knee function in patients with RA, severe osteoporosis, and genu valgum.
Capacity of National Malaria Control Programs to implement vector surveillance: A global analysis
Authors: Russell Tanya L , Farlow Robert , Min Myo , Espino Effie , Mnzava Abraham , Burkot Thomas R. 
Published: August 2020

Abstract
Background
Solving the problem of malaria requires a highly skilled workforce with supporting infrastructure, financial backing and sound program management coordinated by a strategic plan. Here the capacity of NMCPs was analysed to identify the strengths and weaknesses underpinning implementation of vector surveillance and control activities by the core elements of program capacity, being strategic frameworks, financing, human resources, logistics and infrastructure, and information systems.
Results
Across nearly every country surveyed, the vector surveillance programs were hampered by a lack of capacity and capability. Only 8% of NMCPs reported having sufficient capacity to implement vector surveillance. In contrast, 57%, 56% and 28% of NMCPs had the capacity to implement LLINs, IRS and LSM activities, respectively. Largely underlying this was a lack of up-to-date strategic plans that prioritise vector surveillance and include frameworks for decision making and action.
Conclusions
Strategic planning and a lack of well-trained entomologists most heavily limited vector surveillance. Eliminating countries generally had more operational/field staff compared to controlling countries, and also were more likely to have an established system for staff training and capacity building. It is unlikely that controlling countries will make significant progress unless huge investments also go towards increasing the number and capacity of programmatic staff.