bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Prescription Trend Analysis of Methylphenidate: Relation to Study Reports on Efficacy
Authors: Sluiter Maruschka N. , de Vries Ymkje Anna , Koning Lotte G. , Hak Eelko , Bos Jens H. J. , Schuiling-Veninga Catharina C. M. , Batstra Laura , Doornenbal Jeannette M. , de Jonge Peter 
Published: October 2019

Abstract
Use of methylphenidate in children has increased substantially, despite conflicting evidence regarding efficacy. In this study, prescription data were analyzed in relation to the publication of new evidence regarding efficacy. Incidence rates and prescribed doses of methylphenidate increased, with a decline during the last few years. Duration of use is still increasing. In half of the cases, starting dosages are higher than recommended in guidelines. There was little evidence that publication of new evidence directly influenced the use of methylphenidate. Recent and critical study findings should receive more attention to contribute to the development and use of treatment guidelines for ADHD and evidence-based methylphenidate use.
Assessing agri-environmental schemes for semi-natural grasslands during a 5-year period: can we see positive effects for vascular plants and pollinators?
Authors: Berg Åke , Cronvall Erik , Eriksson Åsa , Glimskär Anders , Hiron Matthew , Knape Jonas , Pärt Tomas , Wissman Jörgen , Żmihorski Michal , Öckinger Erik 
Published: October 2019

Abstract
An important function of agri-environmental schemes (AES) is to change management of pastures to better conserve biodiversity. However, the effects of most AES on biodiversity are poorly understood, especially when it comes to effects of AES management over time. The main aim of this study is to investigate if the species richness and abundance of grassland specialists of vascular plants and two important insect pollinator groups (bumblebees and butterflies) differ over time (5 years) in pastures with AES management (two value levels; general values and special values) and pastures without AES management. We also investigate if local vegetation characteristics and landscape composition relate to species richness in semi-natural grasslands. Using data from more than 400 sites we found that species richness of vascular plants (grassland specialists) was higher in pastures with AES management (for special and general values) compared to those without AES, which implies that these schemes do have value of the conservation of plant diversity. However, species richness and abundance of butterflies (grassland specialists) and bumblebees (all species) did not differ significantly among the three AES categories. We found no evidence that the type of AES management caused any changes in species richness of plants, butterflies or bumblebees during the 5 year period of our investigation. It appears that AES management that encourages uniform and minimum levels of grazing can have both positive and negative effects on biodiversity. For example, pollinators may benefit from a lower grazing intensity that could increase flower richness and heterogeneity in vegetation height. However, low grazing intensity may lead to increased cover of trees and shrubs, which can have negative effects for both insect pollinators and vascular plants. The effects of landscape composition were weak and only species richness of bumble bees were associated with landscape composition. Designing management regimes to maintain suitably heterogeneous vegetation layer, and continued long-term monitoring of biodiversity will be critical for safeguarding culturally and functionally important semi-natural grasslands.
Increasing Response Diversity to Intraverbals in Children with Autism Spectrum Disorder
Authors: Lee Gabrielle T. , Hu Xiaoyi , Liu Yanhong , Zou Chouyun , Cheng Xia , Zhao Qi , Huang Jingjing 
Published: October 2019

Abstract
The purpose of this study was to evaluate the effects of intraverbal prompts on response diversity and novelty in intraverbals posed to children with autism spectrum disorder (ASD). The intraverbal prompts involving function, feature, and class (FFC) of an item were used in the training of three questions requiring multiple responses. Two Chinese boys with ASD (aged 5–6 years) served as participants. A multiple-probe across three behaviors design was employed. The results indicated that the intraverbal prompts effectively increased the number of divergent responses to all three questions. Novel responses emerged at a low level while generalization to similar questions was not observed following the training.
Enhancing Empathy in Emotion-Focused Group Therapy for Adolescents with Autism Spectrum Disorder: A Case Conceptualization Model for Interpersonal Rupture and Repair
Authors: Robinson Anna 
Published: October 2019

Abstract
Adolescents with autism spectrum disorder (ASD) are vulnerable to trauma-related experiences due to difficulties in emotion recognition, including recognising their own and others’ emotions, leading to interpersonal conflict and problems in making and maintaining friendships. There are limited intervention methodologies of how to work with interpersonal conflict and relational repair. This paper presents, for the first time, a case conceptualization model of relational rupture and repair as a clinical strategy to guide therapists working therapeutically with clients with ASD. The model is constructed from a task analysis applied to dyads of therapy and Interpersonal Process Recall sessions of Emotion-Focused Group Therapy with autistic adolescents (EFGT-AS). This model shows that when therapists use Interpersonal Process Recall of shared trauma-related experiences and misempathy encounters as a process-guiding method, it leads to a deepening of emotional processing in both cognitive and affective empathy. Autistic adolescents are able to use EFGT-AS to explore self-agency within interpersonal ruptures and enhance self and other cognitive-affective empathy within a relational repair process. This rational-empirical model for working with relational rupture and repair stands as a hypothesis for future testing.
Oxygen in Complex Oxide Thin Films Grown by Pulsed Laser Deposition: a Perspective
Authors: Koster Gertjan , Blank Dave H. A. , Rijnders Guus A. J. H. M. 
Published: October 2019

AbstractFor thin film synthesis of complex oxides, one of the most important issues has always been how to oxidise the material. For a technique like pulsed laser deposition, a key benefit is the relatively high oxygen background pressure one can operate at, and therefor oxidation should be relatively straightforward. However, understanding the microscopic oxidation mechanisms turns out to be rather difficult. In this perspective, we give a brief overview of the sources of oxidation for complex oxide thin films grown by pulsed laser deposition. While it is clear what these sources are, their role in the kinetics of the formation of the crystal structure and oxygen stoichiometry is not fully understood.
The effects of inorganic phosphate on muscle force development and energetics: challenges in modelling related to experimental uncertainties
Authors: Månsson Alf 
Published: October 2019

AbstractMuscle force and power are developed by myosin cross-bridges, which cyclically attach to actin, undergo a force-generating transition and detach under turnover of ATP. The force-generating transition is intimately associated with release of inorganic phosphate (Pi) but the exact sequence of events in relation to the actual Pi release step is controversial. Details of this process are reflected in the relationships between [Pi] and the developed force and shortening velocity. In order to account for these relationships, models have proposed branched kinetic pathways or loose coupling between biochemical and force-generating transitions. A key hypothesis underlying the present study is that such complexities are not required to explain changes in the force–velocity relationship and ATP turnover rate with altered [Pi]. We therefore set out to test if models without branched kinetic paths and Pi-release occurring before the main force-generating transition can account for effects of varied [Pi] (0.1–25 mM). The models tested, one assuming either linear or non-linear cross-bridge elasticity, account well for critical aspects of muscle contraction at 0.5 mM Pi but their capacity to account for the maximum power output vary. We find that the models, within experimental uncertainties, account for the relationship between [Pi] and isometric force as well as between [Pi] and the velocity of shortening at low loads. However, in apparent contradiction with available experimental findings, the tested models produce an anomalous force–velocity relationship at elevated [Pi] and high loads with more than one possible velocity for a given load. Nevertheless, considering experimental uncertainties and effects of sarcomere non-uniformities, these discrepancies are insufficient to refute the tested models in favour of more complex alternatives.
The application of the ‘Gene-deletor’ technology in banana
Authors: Hu Chun-hua , Yang Qiao-song , Shao Xiu-hong , Dong Tao , Bi Fang-cheng , Li Chun-yu , Deng Gui-ming , Li Yi , Yi Gan-jun , Dou Tong-xin 
Published: October 2019

Abstract
Banana (Musa spp.) is an important tropical crop. Banana industry is under biotic and abiotic stresses such as Fusarium wilt, typhoon, cold stress. Genetic engineering offers a powerful strategy to create germplasm of banana with enhanced resistance. The safety of genetically modified organisms has become a bottleneck restricting the popularization and application of genetically modified technology. In this study, a candidate promoter, LEAFY (LFY) for expression and flower initiation in Arabidopsis, was cloned and constructed to ‘Gene-deletor’ vector. Histochemical β-glucuronidase (GUS) staining results showed that the ‘Gene-deletor’ vector driven by LFY promoter could lead to 88.5% excision efficiency from Arabidopsis seeds based on more than 200 T3 progeny examined per event. GUS staining was found to be partially negative in transgenic bananas, however, polymerase chain reaction could still detect the presence of large fragments of the vector. These results suggest that although LFY promoter could not completely drive the ‘Gene-deletor’ vector to achieve the effect of complete elimination of exogenous gene in bananas, its efficiency of eliminating exogenous gene laid a theoretical foundation for cloning banana fruit-specific promoters, that is, ‘non-transgenic’ GM bananas.
Dual L1-Normalized Context Aware Tensor Power Iteration and Its Applications to Multi-object Tracking and Multi-graph Matching
Authors: Hu Weiming , Shi Xinchu , Zhou Zongwei , Xing Junliang , Ling Haibin , Maybank Stephen 
Published: October 2019

AbstractThe multi-dimensional assignment problem is universal for data association analysis such as data association-based visual multi-object tracking and multi-graph matching. In this paper, multi-dimensional assignment is formulated as a rank-1 tensor approximation problem. A dualL1-normalized context/hyper-context aware tensor power iteration optimization method is proposed. The method is applied to multi-object tracking and multi-graph matching. In the optimization method, tensor power iteration with the dual unit norm enables the capture of information across multiple sample sets. Interactions between sample associations are modeled as contexts or hyper-contexts which are combined with the global affinity into a unified optimization. The optimization is flexible for accommodating various types of contextual models. In multi-object tracking, the global affinity is defined according to the appearance similarity between objects detected in different frames. Interactions between objects are modeled as motion contexts which are encoded into the global association optimization. The tracking method integrates high order motion information and high order appearance variation. The multi-graph matching method carries out matching over graph vertices and structure matching over graph edges simultaneously. The matching consistency across multi-graphs is based on the high-order tensor optimization. Various types of vertex affinities and edge/hyper-edge affinities are flexibly integrated. Experiments on several public datasets, such as the MOT16 challenge benchmark, validate the effectiveness of the proposed methods.
Changes in Body Mass Index and Quality of Life—Population-Based Follow-up Study COURAGE and COURAGE-POLFUS, Poland
Authors: Zawisza Katarzyna , Tobiasz-Adamczyk Beata , Galas Aleksander , Jabłońska Katarzyna , Grodzicki Tomasz 
Published: October 2019

AbstractThe study aimed to verify an association between changes in body mass index (BMI) and quality of life (QoL) in a 4-year follow-up in a population-based study in Poland. The results covered data from 1557 adults from the general Polish population who participated in the follow-up survey, performed in two waves: 2011 (COURAGE in Europe); 2015/2016 (COURAGE-POLFUS). Anthropometric measurements and a structured questionnaire including the WHOQOL-AGE scale were used. Regression models were applied to verify whether the observed BMI–QoL association is linear or U-shaped. The inverse U-shaped association between BMI changes and QoL among Polish adults was found using a univariable model. This association was observed in women, whereas in men a linear relationship was found. At the population level, weight loss (BMI decrease of 5–10%) was associated with better QoL in healthy people. The reverse was true in sick people, whose weight loss was observed to be an indicator of poorer QoL. In conclusion, the study suggests an inverse U-shaped association between BMI and quality of life. Better QoL may be considered an additional benefit of public weight loss programs for healthy adults. Further studies focusing on people with some chronic diseases are needed.
Analysis of national and local governance systems to achieve the sustainable development goals: case studies of Japan and Indonesia
Authors: Morita Kanako , Okitasari Mahesti , Masuda Hiromi 
Published: October 2019

Abstract
To achieve the sustainable development goals (SDGs), all countries’ efforts are essential, and each country needs to recognize their level of achievement in terms of the SDGs, identify the goals and targets that require more effort, and build more effective and well-performed governance systems to accelerate their efforts toward achieving the SDGs. This study identifies different governance system structures for achieving the SDGs and the challenges they face in improving their performance using a new matrix tool to evaluate governance systems for the SDGs. We use Japan and Indonesia as case studies to provide perspectives from countries at different levels of economic development. The results show that the governance systems for the SDGs are structurally and functionally different in the two countries, which face different challenges. Japan has relatively well-structured “vision and objective setting”, “research and assessment”, and “strategy development”, but faces challenges in relation to “implementation” and “monitoring, evaluation, and review”, while Indonesia has relatively well-structured “research and assessment”, “strategy development”, and “monitoring, evaluation, and review.” However, Indonesia faces challenges in relation to “vision and objective setting” and “implementation.” We found that the differences in the governance systems for the SDGs have arisen in relation to three key elements: differences in the development of governance systems for the SDGs, differences in the lead ministries, and the existence or otherwise of a supportive legal framework. We argue that the proposed matrix tool is useful in identifying the structure of governance systems for the SDGs and the challenges that must be overcome to improve the performance of these systems. However, some analytical limitations must be overcome before the tool can be applied to other countries.
Is there a host-associated molecular and morphological differentiation between sympatrically occurring individuals of the invasive leaf miner Cameraria ohridella?
Authors: Melosik Iwona , Walczak Urszula , Staszak Julia , Winnicka Katarzyna , Baraniak Edward 
Published: October 2019

AbstractThe leaf-miner mothCameraria ohridella,a pest in Central Europe, causes severe damage to trees. Host-associated differentiation (HAD) for this species has been suggested previously based on the occurrence of a specific mitochondrial haplotype. We assessed genetic diversity and population structure for sympatrically occurring individuals collected in association with two host species, Ohio buckeye (Aesculus glabra) and horse chestnut (Ae. hippocastanum), using six microsatellite loci (SSR) and mtDNA sequences that encode parts of cytochrome oxidase I and II. To infer population structure and assign individuals to clusters, we employed Bayesian clustering. We further characterized the relationships between genetic distance and geographical distance (IBD) in analyzed samples. Although our results derived from the SSR loci analyses demonstrating that there was no population substructuring caused by the hosts, we found evidence of differences in wing size, which might be attributed to the quality of food resources available to larvae. The population structure withK = 2 cannot be interpreted as the result of IBD; rather, it reflects a population differentiation due to demographic or genetic processes (e.g., an origin of invaders). Although genetic diversity was relatively high (He> 0.5), the population had a deficiency of heterozygotes (FIS > 0), which was most likely due to nonrandom mating and, possibly, a Wahlund effect. A star-like haplotype network and negative Tajima’s D support the genetic effect of bottleneck followed by population expansion. Based on presumably neutral markers, we conclude thatC. ohridellaappeared to be a good model for studying evolution toward a generalist invasive species, rather than HAD.
Debunking (the) Retribution (Gap)
Authors: Kraaijeveld Steven R. 
Published: October 2019

AbstractRobotization is an increasingly pervasive feature of our lives. Robots with high degrees of autonomy may cause harm, yet in sufficiently complex systems neither the robots nor the human developers may be candidates for moral blame. John Danaher has recently argued that this may lead to a retribution gap, where the human desire for retribution faces a lack of appropriate subjects for retributive blame. The potential social and moral implications of a retribution gap are considerable. I argue that the retributive intuitions that feed into retribution gaps are best understood as deontological intuitions. I apply a debunking argument for deontological intuitions in order to show that retributive intuitions cannot be used to justify retributive punishment in cases of robot harm without clear candidates for blame. The fundamental moral question thus becomes what we ought to do with these retributive intuitions, given that they do not justify retribution. I draw a parallel from recent work on implicit biases to make a case for taking moral responsibility for retributive intuitions. In the same way that we can exert some form of control over our unwanted implicit biases, we can and should do so for unjustified retributive intuitions in cases of robot harm.
Systemic Administration of Rejuvenated Adipose-Derived Mesenchymal Stem Cells Improves Liver Metabolism in Equine Metabolic Syndrome (EMS)- New Approach in Veterinary Regenerative Medicine
Authors: Marycz Krzysztof , Szłapka-Kosarzewska J. , Geburek F. , Kornicka-Garbowska K. 
Published: October 2019

Abstract
Equine metabolic syndrome (EMS) is characterized by adiposity, insulin dysregulation and increased risk for laminitis. Increased levels of specific liver enzymes in the peripheral blood are typical findings in horses diagnosed with EMS. Current management of EMS is based on caloric restriction and increased physical activity. However, new potential treatment options are arising such as the transplantation of autologous adipose stem cells (ASC). However, cytophysiological properties of ASC derived from EMS horses are impaired which strongly limits their therapeutic potential. We hypothesized, that in vitro pharmacotherapy of those cells with 5-azacytidine (AZA) and resveratrol (RES) before their clinical application can reverse the aged phenotype of those cells and improve clinical outcome of autologous therapy. A 9 year old Dutch Warmblood Horse used for driving, was presented with severe obesity, insulin resistance. After EMS diagnosis, the animal received three intravenous injections of autologous, AZA/RES treated ASCs at weekly intervals. The therapeutic effect was assessed by the analysis of liver specific enzymes in the blood. ASC-transplantation reduced levels of glutamate dehydrogenase (GLDH), gamma-glutamyltransferase (GGT), lactate dehydrogenase (LDH) and aspartate transaminase (AST). This case report demonstrates the therapeutic potential of this intervention for EMS as well as apt utility of autologous, rejuvenated ASC injections.
Geochemistry of Dalma metavolcanic Suite from Proterozoic Singhbhum Mobile Belt, Eastern India: Implications for Petrogenesis and Tectonic Setting
Authors: Alvi Shabber H. , Mir Akhtar R. , Bhat Irfan M. 
Published: October 2019

ABSTRACT
The Dalma metavolcanic belt is composed of ultramafics at the base, tuffs on top and basalts in-between. It extends for about 200kms east-west in the middle of the Proterozoic Singhbhum Mobile Belt. Ultramafics are chiefly composed of actinolite, hornblende, relic pyroxene and olivine. The main mineral constituents of basalts are actinolite, hornblende, chlorite, epidote, clinozoisite and plagioclase whereas; tuffs are composed of xenocrysts of biotite, quartz, k-feldspar, plagioclase and iron oxides. Ultramafic samples have high MgO (&gt; 21 wt.%) and low SiO2 (&lt; 42 wt.%), Al2O3 (&lt; 10 wt.%) and Na2O+K2O (&lt; 1 wt.%). CaO shows large variation in these samples from 3.91 to 7.77 wt. %. In studied basalt samples SiO2, TiO2, Al2O3, MgO and alkalis (Na2O+K2O) show variation like (45.7-48.3 wt.%), (0.64-0.97 wt.%), (9.3-13.9 wt.%), (8.5-13.6 wt.%) and (0.95-4.64 wt.%) respectively. In studied tuffs the SiO2, TiO2, Al2O3, MgO and alkalis show variation from (48.9-49.8 wt.%), (0.7-0.8 wt.%), (13.6-13.9 wt.%), (8.4-9.1 wt.%) and (2.39-2.85 wt.%) respectively. In general, studied samples show light rare earth element depleted patterns and flat patterns for heavy rare earth elements similar to MORBs on chondrite normalized REE diagrams. The overall enrichment of LILEs (e.g., Rb, K and Th) and depletion of HFSEs (e.g., Nb-Ta trough) on primitive mantle normalized multi-element diagrams are similar to subduction zone or islamd arc basalts. Ratios like Ti/Y, Ti/Zr, Zr/Nb and Ti/V are also similar to those found in arc related volcanic suites. Sm/Yb vs La/Sm diagram indicates generation of melts from the spinel lherzolite mantle source. On tectonic setting discrimination diagrams like Zr vs Zr/Y, Zr vs Ti and Ti vs V majority of studied samples clearly show island arc tectonic affinity.