bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research
Authors: Madhavan Mahesh V. , Bikdeli Behnood , Gupta Aakriti , Jimenez David , Burton John R. , Der Nigoghossian Caroline , Chuich Taylor , Nouri Shayan Nabavi , Dreyfus Isaac , Driggin Elissa , Sethi Sanjum , Sehgal Kartik , Chatterjee Saurav , Ageno Walter , Madjid Mohammad , Guo Yutao , Tang Liang V. , Hu Yu , Bertoletti Laurent , Giri Jay , Cushman Mary , Quéré Isabelle , Dimakakos Evangelos P. , Gibson C. Michael , Lippi Giuseppe , Favaloro Emmanuel J. , Fareed Jawed , Tafur Alfonso J. , Francese Dominic P. , Batra Jaya , Falanga Anna , Clerkin Kevin J. , Uriel Nir , Kirtane Ajay , McLintock Claire , Hunt Beverley J. , Spyropoulos Alex C. , Barnes Geoffrey D. , Eikelboom John W. , Weinberg Ido , Schulman Sam , Carrier Marc , Piazza Gregory , Beckman Joshua A. , Leon Martin B. , Stone Gregg W. , Rosenkranz Stephan , Goldhaber Samuel Z. , Parikh Sahil A. , Monreal Manuel , Krumholz Harlan M. , Konstantinides Stavros V. , Weitz Jeffrey I. , Lip Gregory Y. H. ,   The Global COVID-19 Thrombosis Collaborative Group
Published: May 2020

AbstractCoronavirus disease 2019 (COVID-19), currently a worldwide pandemic, is a viral illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The suspected contribution of thrombotic events to morbidity and mortality in COVID-19 patients has prompted a search for novel potential options for preventing COVID-19-associated thrombotic disease. In this article by the Global COVID-19 Thrombosis Collaborative Group, we describe novel dosing approaches for commonly used antithrombotic agents (especially heparin-based regimens) and the potential use of less widely used antithrombotic drugs in the absence of confirmed thrombosis. Although these therapies may have direct antithrombotic effects, other mechanisms of action, including anti-inflammatory or antiviral effects, have been postulated. Based on survey results from this group of authors, we suggest research priorities for specific agents and subgroups of patients with COVID-19. Further, we review other agents, including immunomodulators, that may have antithrombotic properties. It is our hope that the present document will encourage and stimulate future prospective studies and randomized trials to study the safety, efficacy, and optimal use of these agents for prevention or management of thrombosis in COVID-19.
Longitudinal analysis reveals transition barriers between dominant ecological states in the gut microbiome
Authors: Levy Roie , Magis Andrew T. , Earls John C. , Manor Ohad , Wilmanski Tomasz , Lovejoy Jennifer , Gibbons Sean M. , Omenn Gilbert S. , Hood Leroy , Price Nathan D. 
Published: May 2020

SignificanceDeep molecular phenotyping of individuals provides the opportunity for biological insight into host physiology. As the human microbiome is increasingly being recognized as an important determinant of host health, understanding the host–microbiome relationship in a multiomics context may pave the way forward for targeted interventions. In this study, we analyze gut microbial composition of 101 individuals over the course of a year, alongside clinical markers and serum metabolomics. We establish association between specific gut compositional states and host health biomarkers (e.g., of inflammation). Finally, we provide evidence for an apparent transition barrier between these compositional states. A deeper understanding of microbiome dynamics and the associated variation in host phenotypes furthers our ability to engineer effective interventions that optimize wellness.
Adverb placement in EFL academic writing
Authors: Larsson Tove , Callies Marcus , Hasselgård Hilde , Laso Natalia Judith , van Vuuren Sanne , Verdaguer Isabel , Paquot Magali 
Published: May 2020

Abstract
The present study looks at adverb placement in expert writing and in first-language and second-language novice spoken and
written production. The extent to which first-language (L1) transfer is still present in advanced learners’ written production is also
investigated. The study uses data from one expert corpus (LOCRA), two native-speaker student
corpora (BAWE and LOCNEC) and two learner corpora (VESPA and LINDSEI). The results highlight the importance of taking mode into consideration, as clear distributional
differences were found between spoken and written production. In addition, while considerable differences could be noted across L1
background in the spoken data, factors such as presence/absence of auxiliary, verb type (e.g. intransitive, copular/linking) and lexis were
found to be most important for predicting adverb placement in the written data. Only very limited evidence of L1 transfer was found in the
learners’ writing, suggesting that advanced learners have largely mastered the distributional preferences of adverbs.
An interpreter advantage in executive functions?
Authors: Nour Soudabeh , Struys Esli , Woumans Evy , Hollebeke Ily , Stengers Hélène 
Published: May 2020

Abstract
The aim of this systematic literature review was to answer the question of which executive function is most
affected by interpreter training and experience. We used the ‘unity and diversity’ framework of executive functions to distinguish
between three executive components: Response and Distractor Inhibition, Shifting, and Updating.
Among the seventeen studies included in the review, we only found evidence for an interpreter advantage on
Shifting and Updating, but with a different pattern for each of these. With regard to
Updating, groups of interpreters scored better than comparison groups, but general trend in longitudinal
studies did not show an improvement for interpreter trainees. In contrast, for Shifting, scores improved as a
result of interpreting training. Our systematic review stresses the importance of understanding the diversity of executive
processes when investigating the relationship between interpreting and cognitive performance.
Onchocerciasis: status and progress towards elimination
Authors: Hopkins Adrian D. 
Published: May 2020

Abstract

Craw craw was first described almost 150 years ago. Since then considerable progress has been made in understanding the
Onchocerca volvulus
life cycle, its effects on the host (blindness, skin disease and epilepsy) and potential control measures. Early attempts were aimed at controlling the black fly (
Simulium
) that transmits the disease. This included the early use of DDT in some isolated foci in East Africa. This was followed in the 1970s by the Onchocerciasis Control Programme (OCP) of West Africa using other safer insecticides. In 1987, MSD (known as Merck & Co Inc. in the USA and Canada) announced the donation of Mectizan
®
(ivermectin MSD) as long as was necessary for onchocerciasis control. This began a new chapter in the control of the disease including the creation of the African Programme for Onchocerciasis Control (APOC) and the Onchocerciasis Elimination Programme for the Americas (OEPA). In the Americas, four countries have now been verified free of transmission of the disease by the World Health Organisation. In Africa where foci are considerably larger, APOC with its partners has succeeded in developing a control programme covering virtually all areas where the prevalence of the disease can cause serious effects. In some disease foci in Africa, elimination of transmission has been achieved. Following surveys on the Mali Senegal border, there was a move in 2009 to change the paradigm from control to elimination. Development has been slow but by 2030, there is hope that most countries will have stopped treatment and others will have completed post-treatment surveillance surveys although some foci in conflict areas will remain.
Alternatives to synthetic pesticides for the management of the banana borer weevil (
Cosmopolites sordidus
) (Coleoptera: Curculioniidae)
Authors: Okolle N.J. , Ngosong C. , Nanganoa L.T. , Dopgima L.L. 
Published: May 2020

Abstract

Bananas and plantains are important staple crops for many people in developing countries, but these crops are severely affected by biotic constraints that reduce productivity. A major biotic stress is the banana corm borer weevil (
C. sordidus
) whose larvae eat corm/pseudostem tissues that eventually weaken the plants and cause toppling. To manage these borer weevils, most farmers use synthetic pesticides with active ingredients from different pesticide groups. Over reliance and abusive use of pesticides result in detrimental effects on the environment and human health. These effects together with ecological backlashes such as development of resistance by the pest have led to numerous advocacies to minimize the use of these chemicals. To achieve this, there has been increasing number of researches to seek sustainable alternatives that could be used to replace these synthetic pesticides or be integrated with less toxic chemicals to effectively manage the pest. This review summarizes global research on the use of synthetic pesticides and alternative management techniques such as the use of appropriate cultural practices (e.g., clean planting materials, fallowing, mulching, intercropping, and trapping), botanical pesticides (e.g., from Solanaceae, Asteraceae, and Meliaceae), entomopathogens, predators/parasitoids, and the use of resistant crop varieties, as well as possibilities of engineering phytocystatins to produce transgenic varieties that will be harmful to weevil. The review ends with conclusions, limitations/gaps, and recommendations for future research for the different alternative options.
Chitinase system of Aeromonas salmonicida, and characterization of enzymes involved in chitin degradation
Authors: Pentekhina Iuliia , Hattori Tatsuyuki , Tran Dinh Minh , Shima Mizuki , Watanabe Takeshi , Sugimoto Hayuki , Suzuki Kazushi 
Published: May 2020

Abstract
The genes encoding chitin-degrading enzymes in Aeromonas salmonicida SWSY-1.411 were identified and cloned in Escherichia coli. The strain contained two glycoside hydrolase (GH) families 18 chitinases: AsChiA and AsChiB, two GH19 chitinases: AsChiC and AsChiD, and an auxiliary activities family 10 protein, lytic polysaccharide monooxygenase: AsLPMO10A. These enzymes were successfully expressed in E. coli and purified. AsChiB had the highest hydrolytic activity against insoluble chitin. AsChiD had the highest activity against water-soluble chitin. The peroxygenase activity of AsLPMO10A was lower compared to SmLPMO10A from Serratia marcescens. Synergism on powdered chitin degradation was observed when AsChiA and AsLPMO10A were combined with other chitinases of this strain. More than twice the increase of the synergistic effect was observed when powdered chitin was treated by a combination of AsLPMO10A with all chitinases. GH19 chitinases suppressed the hyphal growth of Trichoderma reesei.
Hizikia fusiforme extract enhances dendritic cell maturation in vitro and in vivo
Authors: Kim Mi Eun , Cho Jun Hwi , Jung Inae , Kim Hyung Keun , Lee Jun Sik 
Published: May 2020

Abstract

Dendritic cells (DCs) are play critical roles in the priming and regulation of immune responses. DCs rapidly process and convey these antigens to prime antigen-specific T cells. Therefore, regulation of DCs functions is important for immunity and immunotherapies. Immune adjuvants for DCs activation are needed to improve the efficacy of vaccines against tumors and many infectious diseases. Therefore, we demonstrate that H. fusiformis extract can regulate DCs maturation and activation. H. fusiformis extract induced costimulatory molecules (CD 80 and CD86), antigen-presenting molecules (major histocompatibility complex (MHC) I and II), CCR7 expression, and interleukin (IL)-12 production in DCs. These effects are associated with upregulation of mitogen-activated protein kinase (MAPK) signaling pathway. In addition, H. fusiformis extract induces costimulatory molecules on splenic DCs and activated CD8+ T cells in vivo. Taken together, these findings suggest that H. fusiformis extract may be a potential efficient immune therapeutic compound in DCs-mediated immunotherapies.

Abbreviations
CTL: cytotoxic T lymphocytes; DCs: dendritic cells; ERK: extracellular signal-regulated kinases; IL: interleukini; JNK: c-Jun N-terminal kinase; MAPK: mitogen-activated protein kinase; MHC: major histocompatibility complex
Evaluation of a 3D printed OSL eye lens dosimeter for photon dosimetry
Authors: Santos M F , Filho W C V , Melo G T P , Asfora V K , Khoury H J , Barros V S M 
Published: May 2020

Abstract
This work demonstrates the use of high-resolution 3D printing to fine-tune the low energy dependence of an eye lens dosimeter holder associated to a BeO OSL detector element (ezClip). Five geometries of the denominated iBe dosimeter were developed, three with a variation in the thickness of the wall in front of the sensitive element that tailor the response at low radiation energies; and three with variations of width and curvature in order to vary the angular response of the dosimeter badges. Additive manufacturing was accomplished using stereolithography which gave a high degree of accuracy and precision. The optimised dosimeter badges showed a low energy and angular dependence, within −20% to +20% in the energy range of 24 keV to 662 keV and from 0 to 60° incidence; and within −10% to +10% in the energy range of 24 keV to 164 keV and from 0 to 60° incidence. In contrast to other dosimeters with higher effective atomic numbers, the use of BeO as the sensitive element resulted in a flat energy and angular dependence response at low energies. A significant reduction in the measurement uncertainty in the diagnostic radiology energy range was achieved.
Conventional vs Microwave assisted SiO2/P2O5 catalyzed synthesis of Schiff bases
Authors: Mishra N , Yadav R , Kumar K , Pandey H , Pandey R 
Published: May 2020

Abstract
Here in this work we have carried out synthesis of isoniazid and their benzaldehyde derivative in the presence of SiO2/P2O5 catalyzed utilizing conventional and microwave assisted protocols. Both these protocols examined comparatively and we found that microwave assisted synthesis is more efficient, eco-friendly and economical method as compared to conventional method. Yield of product is also higher than conventional method. Use of heterogeneous catalyst is also promoting the yield of product and it is very easy to separate from the product by simple filtration and centrifugation. These synthesized compounds are characterized by physical and spectral studies (IR, UV-VIS, NMR spectroscopy) Isoniazid having excellent antitubercular activity and due to presence of Isoniazid they may have good antibiotic property.
Mathematical modeling and analysis with various parameters, for infection dynamics of Tuberculosis
Authors: Rana P S , Sharma N 
Published: May 2020

Abstract
Mathematical model is needed to study the epidemiology of tuberculosis. Here we have proposed a model that is more realistic. We are exhibiting a theoretical framework for getting the control and eradication methodologies to minimize the number of infectious tuberculosis cases in the community. For this purpose, the model population has been compartmentalized and the consequential model equations have been solved analytically. Numerical Simulation has been given to validate the results obtained by the theoretical approach. The effect of latent periods on the epidemics of tuberculosis with respect to population density has been studied. The equilibrium points of the model are calculated and their stability is established by using the ‘Basic Reproduction number’. It is observed that when basic reproduction number is less or equal to unity, the disease-free equilibrium point (DEF) is globally asymptotically stable, while when it is greater to unity, the endemic equilibrium point (EE) is globally asymptotically stable i.e., illness will persist in the population and epidemic will turn out to be endemic. Also, it is obtained that compactness of people decides the infection rate of tuberculosis i.e. the risk of instability of disease free equilibrium increases as the population density increases.
Adsorption study of Heavy Metals from Aqueous Solutions using Magnetite Nanoparticles
Authors: Anamika  , Singh Virendra , Yadav Basant K 
Published: May 2020

AbstractContamination of heavy metals in wastewater is a significant worldwide problem, which is causing to detrimental effect on human health and environment. In present work, magnetite nanoparticles were used for the expulsion of Pb(II) and Cd(II) ions from aqueous solutions at varying pH conditions, contact time and adsorbent amounts. Magnetite nanoparticles were synthesized by co-precipitation method. Synthesized nanoparticles were characterized by XRD, FTIR, UV-Vis, VSM and SEM techniques for structural, optical, magnetic and morphological properties. The crystalline nature of magnetite nanoparticles with crystallite size 10.16 nm was confirmed by XRD. Optical properties and functional group identification of magnetite nanoparticles were revealed by UV-Vis and FTIR spectroscopy respectively. VSM measurements showed that the saturation magnetization of magnetite nanoparticles was 56.42 emu/g. This indicates that after adsorption, an easy separation of metal loaded magnetite nanoparticles from aqueous solutions can be achieved by applying the external magnetic field. Adsorption experiments results showed that the adsorption capacity of magnetite nanoparticles is higher for Pb(II) ions. At optimum conditions, the maximum removal efficiencies for Pb(II) and Cd(II) ions were 98.6% and 93% respectively. Langmuir and Freundlich adsorption isotherms were found suitable for adsorption processes. The adsorption kinetic data for both the metal ions were best fitted by pseudo second order reaction. Surface images of bare and metal loaded magnetite nanoparticles supported the confirmation of adsorption of metal ions on nanoparticles surface. Thus, it is concluded that magnetite nanoparticles can be effectively used as an adsorbent for expulsion of heavy metals from aqueous solutions.
A compatible standard policy measure to tackle solar photovoltaic waste in Indian scenario
Authors: Sheoran Manisha , Sharma Susheela , Kumar Pancham 
Published: May 2020

Abstract
Expeditious evolution of solar photovoltaic industry has triggered transformation in energy sector across the world. After the concluded durability of the PV panels amount of junk originates. This junk is directed into the category of solid waste. With the increasing solar power plant installations in India the amount of waste to be accumulated in the nearby years to come will be a matter of grave concern. Hasty action should be taken by the Indian policy makers and other non-governmental agencies to process the solar photovoltaic recycling policies at commercial level in an economically sustainable manner. This paper inspects the prospective requisite of PV reprocessing legislation by investigating the current reprocessing arrangements of the commercialized first and second generation solar PV materials. Emphasis is also laid on the hazardous effects of the waste on human body. Quantity of reclaimed material is considered and its economic importance is analysed. Architectural liability is put at the utmost front for curbing out the havoc to be created by piling up of the junk photovoltaic materials through economically feasible policy framework. Through this article effective solar PV reclaiming policy framework is proposed for the Indian government which will foster new socio-economic, environmental and employment opportunities.
Electronic properties of lithium tantalate using Compton spectroscopy
Authors: Joshi Pooja K , Arora G , Mali D , Jangid P K , Kumar K , Ahuja B L 
Published: May 2020

Abstract
We have measured the electron momentum density (EMD) of LiTaO3 using 100 mCi 241Am Compton spectrometer. The experimental Compton profile (CP) is compared with theoretical EMDs deduced using linear combination of atomic orbitals (LCAO) method with different exchange and correlation potentials namely PBE, PWGGA and VBH. On the basis of χ2 fit (which scales goodness of fitting) and difference profiles between experimental and theoretical CPs, LCAO-PWGGA potential based CP is found close to experimental results. Electronic properties like energy bands and density of states of LiTaO3 using LCAO-PWGGA potential show a band gap of 4.85 eV of LiTaO3, thereby depicting its semiconductor nature with wide band gap. It is observed that upper valence band region is mainly dominated by 2p states of O and 5d states of Ta, although there is small contribution of 2s states of Li in this region.
First principles calculations to probe electronic response of lithium tetraborate
Authors: Jangid Pawan K , Arora Gunjan , Mali Deepika , Joshi P K , Kumar Kishor , Ahuja B L 
Published: May 2020

Abstract
Electronic structure of thermoluminescent (TL) lithium tetraborate (Li2B4O7) using density functional theory is presented. We have computed the E-k relations and density of states (DOS) by applying ab-initio LCAO and FP-LAPW theories. The band gaps obtained using local density approximation (LDA) within LCAO and FP-LAPW approaches are found to be 6.48 and 5.84 eV, respectively at Γ point of BZ leading to its direct band gap character. Our LCAO based computations give close agreement with experimental value of 7.9 eV. The DOS curves validate the dominance of O-2p states in the top valence band with a minor role of B-2p electrons. The conduction band region consists of dominant contribution of B-2p states.
A recursive pattern recognition approach to selection web services in cloud environment
Authors: Adarme M A , Jimeno M A , Puerto E G 
Published: May 2020

AbstractThere are optimization problems in the Cloud for the selection of web services, due to the large number of services available by different cloud providers and the diversity of quality of service parameters of each of them. This work proposes the adaptation of a pattern recognition model based on the systematic functioning of the brain called Ar2p for the selection of web services in composition activities in Cloud environments. The web serice are represented as patterns to be recognized by Ar2p, which determines the necessary and sufficient web services that constitute the composition of services that meet its functional and non-functional requirements. The services composition and activity selection have been formalized through a logical-mathematical model of web service recognition mechanisms in two steps, one that describes the syntactic search of the service and the second, which offers filtering through quality of service parameters. An adaptive implementation of the final model allows its recognition modules to be provided with any desired optimization strategy.
Design of a hybrid transmission system using wavelength division multiplexing and subcarrier under the frequency frame for 5G
Authors: Cuesta-Quintero F R , Puerto-Leguizamón G , Rico-Bautista D W , Cuesta-Quintero B , Coronel-Rojas L A 
Published: May 2020

Abstract
This article proposes the design of a hybrid transmission system using wavelength division multiplexing and subcarrier under the frequency frame for 5G. The proposal is evaluated through modeling based on simulation of the generation of optical carriers using a broadband source in combination with an optical filter configured with different pass bands and transmission at different distances. The simulation model evaluated the signal quality levels in terms of the Q factor, taking into account the frequency framework for 5G (5 GHz, 30 GHz and 60 GHz) and the optical fiber length (5 km, 10 km, 15 km, 20 km, 25 km, 30 km). The results obtained show that the best performance of the Q factor compared to distances was that of the 30 GHz frequency, both in the access network and in the metro network. It was also possible to demonstrate that through a broadband light source and a waveguide grating array it is possible to obtain optical carriers for the transmission of signals in a hybrid wavelength division multiplexing and subcarrier transmission system.