bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Rapid Shift from Chronic Hyperoxia to Normoxia Induces Systemic Anaphylaxis via Transient Receptor Potential Ankyrin 1 Channels on Mast Cells
Authors: Matsuda Kenshiro , Arkwright Peter D. , Mori Yasuo , Oikawa Masa-aki , Muko Ryo , Tanaka Akane , Matsuda Hiroshi 
Published: October 2020

Abstract
Extensive activation of mast cells is the major switch that triggers systemic anaphylaxis, resulting in the subsequent release of anaphylactic mediators into circulation. We previously demonstrated that rapid changes in oxygen tension lead to mast cell degranulation, and the released tryptase triggers retinal angiogenesis in a murine oxygen-induced retinopathy model. However, whether a rapid shift from hyperoxia to normoxia (relative hypoxic stress) is a risk factor for systemic anaphylaxis remains unknown. In this study, we demonstrated that the relative hypoxia stress induces systemic mast cell activation via transient receptor potential ankyrin 1 (TRPA1) channels, which immediately leads to hypothermia and increased vascular permeability in adult mice. Although mast cell–deficient or TRPA1-deficient mice did not exhibit anaphylactic symptoms following a rapid sift to normoxia, preinjection with bone marrow–derived cultured mast cells (BMCMCs) derived from wild-type TRPA1-expressing mice restored anaphylactic responses. In addition, we found that the rapid reductions in oxygen tension in a culture atmosphere triggered the degranulation of BMCMCs derived from wild-type TRPA1-expressing mice but not that of BMCMCs derived from TRPA1-deficient mice. In human LAD2 mast cells, the relative hypoxic stress led to the degranulation, which was suppressed by the addition of a TRPA1 inhibitor. Gradual reductions from hyperoxia to normoxia led to no anaphylactic symptoms. Our results demonstrated that TRPA1-triggered mast cell degranulation is a novel pathway that induces anaphylactic shock without Ag–Ab reactions. These findings introduce a potential role for oxygen in inducing mast cell–dependent anaphylaxis and highlight the need to reconsider chronic pure oxygen therapy for anoxic diseases.
Evaluation of spinopelvic parameters in lumbar prolapsed intervertebral disc
Authors: Poonia Apoorva , Lodha Sambhav , Sharma N C 
Published: October 2020

Abstract
Background: Sacro-pelvic morphology and orientation are usually described in terms of pelvic incidence (PI), pelvic tilt (PT), and sacral slope (SS). Orientation and morphology of pelvis can affect degenerative changes in the lumbar spine. Thus, here we investigated the relationships between various sagittal spinopelvic parameters and the degree of disc degeneration in young adults. Material and Methods: A hospital-based cross-sectional study with a total of 60 cases was done. Patients presenting with back or leg pain having prolapsed disc on magnetic resonance imaging (MRI) were included in the study. A standing X-ray of LS spine from dorso-lumbar junction to mid-thigh was taken. Various spinopelvic parameters were assessed from the scannogram using the software. Results: The mean age was 39.27 years. L5S1 was the most common level. Mean SS, PT, PI, and LL were 37.78°, 13.52°, 51.33°, and 41.01°. Disc pathologies at L1L2, L2L3, and L4L5 level showed a positive correlation with PT, PI, and LL. Disc pathology at the L5S1 level shows a positive correlation with PT and LL. A statistically significant correlation between SS and degenerative spondylolisthesis at L4L5 was found from data with P = 0.023. Discussion: An increase in SS statistically significantly increases the chance of development of degenerative spondylolisthesis at L4L5. An increase in PT, PI, and LL will cause an increase in disc pathology at L1L2. An increase in SS, PT, PI, and LL will cause an increase in disc pathology at L2L3. An increase in SS, PT, PI, and LL will cause an increase in disc pathology at L4L5. An increase in PT and LL will cause an increase in disc pathology at L5S1. Conclusion: Standing lateral view radiograph from dorso-lumbar junction to the mid-thigh is as good as standing whole spine radiograph for measurement of spinopelvic parameters. Degenerative spondylolisthesis at L4L5 has a statistically significant correlation with an increase in SS.
PET-CT upstaging of unilateral operable breast cancer and its correlation with molecular subtypes
Authors: Singh Srishti , Raghavan Bagyam , Geethapriya Sivaramalingam , Sathyasree V V , Govindaraj Jayaraj , Padmanabhan G , Krishna Murali , Arafath Rasheed 
Published: October 2020

Abstract
Context: Prognosis and survival rates for breast cancer vary greatly depending on the cancer stage of the patient. Instead of a step-by-step approach using multiple investigations, we can get all the information about the metastatic load of the disease in PET-CT imaging by one single investigation. There is also a correlation between prognosis, FDG uptake, and molecular subtype of breast cancer (Luminal A, Luminal B, Human epidermal growth factor receptor 2 (HER2) positive and Triple-negative). Pre-treatment baseline PET-CT scan was done in 156 unilateral early and operable breast cancer patients from November 2017 to April 2019 in our prospective observational study.
Aims:

Results:

Conclusions:
Malignant perivascular epithelioid cell tumor of the ileum on 18F-fluorodeoxyglucose positron emission tomography/computed tomography with pathological correlation
Authors: Das Jeeban , Bou-Ayache Jad , Gollub Marc , Riedl Christopher , Ulaner Gary 
Published: October 2020

AbstractA 75-year-old woman presented with a 1-month history of abdominal pain. Contrast-enhanced computed tomography (CT) demonstrated a large solid mass in the left lower abdominal quadrant, suspicious for malignancy. Staging with 18F-fluorodeoxyglucose (FDG) positron emission tomography/CT imaging demonstrated intense FDG uptake in the mass with no evidence of metastatic disease. Complete surgical resection was performed, and histopathological analysis confirmed a malignant perivascular epithelioid cell tumor of the ileum.
Diffuse bone marrow uptake related to granulocyte colony-stimulating factor-producing maxillary sinus carcinoma on 4-borono-2-18F-fluoro-L-phenylalanine positron emission tomography/computed tomography
Authors: Kusumahstuti Kharisma , Watabe Tadashi , Kitamura Naoya , Yamamoto Tetsuya 
Published: October 2020

AbstractGranulocyte colony-stimulating factor (G-CSF) can be produced by tumor cells and is known to promote tumor growth, thereby potentially accelerating disease progression. Squamous cell carcinoma (SCC) at maxillary sinus is aggressive growth with poor prognosis. Maxillary sinus carcinomas are rare and can be clinically silent in the early stages or manifest with the same signs and symptoms of more common illnesses, leading to their delayed diagnosis of disease. Hypermetabolic uptake of 18F-fluorodeoxyglucose (18F-FDG) but not of 4-borono-2-18F-fluoro-L-phenylalanine (18F-FBPA), in the bone marrow of patients with G-CSF-producing tumors without bone marrow involvement during positron emission tomography (PET), has been reported. The present case report describes our first experience of bone marrow uptake in PET/computed tomography examination using 18F-FBPA, high uptake seen in the bone marrow of a patient with a G-CSF-secreting SCC of the maxillary sinus that it relapsed following chemoradiation therapy and surgical resection of the tumor.
The Unexamined Diversity: Disability Policies and Practices in US Graduate Medical Education Programs
Authors: Meeks Lisa M. , Taylor Nichole , Case Ben , Stergiopoulos Erene , Zazove Philip , Graves Lisa , McKee Michael , Swenor Bonnielin K. , Salgat Anah , Cerilli Caroline , Joshi Heidi , Moreland Christopher J. 
Published: October 2020

ABSTRACT

Background
Graduate medical education (GME) institutions must ensure equal access for trainees with disabilities through appropriate and reasonable accommodations and policies. To date, no comprehensive review of the availability and inclusiveness of GME policies for residents with disabilities exists.

Objective
We examined institutions' compliance with Accreditation Council for Graduate Medical Education (ACGME) requirements and alignment with Association of American Medical Colleges (AAMC) policy considerations.

Methods
Between June and August 2019, we conducted a directed content analysis of GME institutional policies using the AAMC report on disability considerations and the ACGME institutional requirements as a framework.

Results
Of the 47 GME handbooks available for review, 32 (68%) included a disability policy. Forty-one of the 47 (87%) handbooks maintained a nondiscrimination statement that included disability. Twelve of the 32 (38%) handbooks included a specific disability policy and language that encouraged disclosure, and 17 (53%) included a statement about the confidential documentation used to determine reasonable accommodations. Nineteen of the 32 (59%) maintained a clear procedure for disclosing disabilities and requesting accommodations.

Conclusions
While disability policies are present in many of the largest GME institutions, it is not yet a standardized practice. For institutions maintaining a disability policy, many lack key elements identified as best practices in the AAMC considerations.
Problems and Prospects of Poultry Rearing in Lagelu Local Government Area of Oyo State, Nigeria
Authors: Fadimu B.O. , Akinyemi IG , Ogundimu O.A. , Lawal M.O. , Adeyomoye G.A. , Akinlabi T.J. 
Published: October 2020

World poultry production is increasing yearly yet the demand for the products has not been met. This study assessed the problems and prospects of poultry rearing in Lagelu Local Government Area of Oyo State, Nigeria. The study was carried out among poultry farmers with interview schedule of Eighty (80) farmers using structured questionnaires. The study examined social characteristics of poultry farmers, benefits of poultry production, needs and constraints of poultry production in the study area. Descriptive statistical analysis was used to analyze data. The study revealed that 73.80% of the respondents were males and 26.20% were females, 52.60% had tertiary education, 36.20% had secondary school education and 11.20% had primary school education. The result showed that 67.50% of the respondents had increase in egg production, 15.00% had average increase in egg production and 17.50% had no increase in egg production. The respondents had maximum income benefit with 15.00% always having high income, 51.20% low income and 33.80% indicated indifference in their income. In this research work, the poultry farmers shows various needs to boost their production, where 91.20% have problems of good storage facilities, 92.50% with problems of pest and disease control, 88.80% request for training for farmers and 53.8% aimed at credit facilities. The major problems that poultry farmers encounter in the study area are inadequate capital (100.00%), pest and disease (100.00%), lack of credit facilities (100.0%) and high cost of feeding (80.0%) of the respondents.
Keywords: Poultry, production, farmers, problems, constraints
Spatio-temporal Analysis of Urban Growth and Its Effects on Wetlands in Rwanda: The Case of Rwampara Wetland in the City of Kigali
Authors: Rwanyiziri G. , Kayitesi C. , Mugabowindekwe M. , Byizigiro R.V. , Muyombano E. , Kagabika M.B. , Bimenyimana T. 
Published: October 2020

This study aimed at analyzing the spatio-temporal patterns of urban growth and its effects on Rwampara wetland, located in the City of Kigali, Rwanda. First, the study was based on the application of remote sensing technology, where 4 Landsat images (1987, 1999, 2009 & 2018) were classified using maximum likelihood classification algorithm. This helped in analyzing the Land Use and Land Cover (LULC) trends in the study area. Secondly, it used the existing LULC data for the years 1990, 2000, 2010 and 2018 in order to investigate the overall changes in LULC in Kigali City. Finally, semi-structured interviews were used to collect data from local people and decision-makers about their past and future management strategies of Rwampara wetland. In this regard, 30 local communities (mainly natives from the study area), 15 local government authorities at sector and district levels as well as 4 senior government authorities in the central administration were interviewed. The findings revealed that over the past 4 decades, urban growth in Kigali City has rapidly increased at the expense of resource degradation in Rwampara wetland. Specifically, there has been an increase of about 77% of the built-up area over the last 31 years (1987-2018) which has led to the decrease of the wetland surface area from 24 ha in 1987 to only 7.7 ha in 2018. The results also revealed that demographic factors (i.e. a high population growth rate and high population densities) were mainly responsible for urban growth and degradation of wetland resources in the area under investigation.
Keywords: urban growth, wetland, wetland resources, wetland degradation, wetland management
Global Warming and Technologies for Carbon Capture and Storage
Authors: Bull O.S. , Bull I. , Amadi G.K. 
Published: October 2020

Global concern about climate change caused by anthropogenic activities, such as the large scale use of fossil fuels as major energy sources for domestic and industrial application, which on combustion give off carbon dioxide (CO2) into the atmosphere. Deforestation is also reducing one of the natural sinks for CO2. These anthropogenic activities have led to an increase in the concentration of CO2 in the atmosphere and have thus resulted in the warming of the earth’s surface (Global Warming), droughts, melting of ice caps, and loss of coral reefs. Carbon capture and storage (CCS) and other variety of emerging technologies and methods have been developed. These technologies and methods are reviewed in this article.
Keywords: Global warming, carbon capture and storage, amine-based absorbents, Metal-Organic Frameworks
ŘÍZENÍ VÝKONU TRAKČNÍCH NAPÁJECÍCH STANIC 25 KV
Authors: Novák Jaroslav , Mlynařík Ladislav 
Published: October 2020

V první části článku jsou prezentovány hlavní vlastnosti a výhody trakčních napájecích stanic pro soustavu 25 kV 50 Hz s nepřímými polovodičovými měniči. V další části jsou uvedeny informace o perspektivní měničové struktuře pro tyto napájecí stanice. Hlavní část článku je věnována teoretické analýze metody pro synchronizované řízení výkonu napájecích stanic s polovodičovými měniči.
UPLATNENIE VYBRANÝCH NÁSTROJOV CONTROLLINGU V RIADENÍ NÁKLADOV DOPRAVNÝCH PODNIKOV A ICH VYUŽITIE V REPORTINGU
Authors: Poniščiaková Olga , Kicová Eva 
Published: October 2020

Z hľadiska zvyšujúcej sa zložitosti podnikových systémov a ich využitia je nevyhnutným základom každej úspešnej cesty taký systém, ktorý integruje nielen spracovanie informácií, tvorbu plánov, ale aj analýzu a kontrolu. Veľmi dôležitá je aj možnosť prijímať správne a rýchle rozhodnutia, čím sa znižuje pravdepodobnosť možných rizík a nebezpečenstiev na minimum. Controlling je v tomto kontexte veľmi dôležitým nástrojom pre podporu riadenia a rozhodovania. Príspevok prináša analýzu controllingových nástrojov s ohľadom na ich uplatnenie v riadení dopravných spoločností. Dôraz je kladený najmä na controllingové riadenie nákladov, ich controllingovú kategorizáciu v špecifických podmienkach dopravných podnikov ako aj ich následné využitie pri riadení zisku. Pre dosiahnutie cieľa boli využité viaceré metodológie, nielen pri čiastkových cieľoch - získavaní a spracovávaní teoretických poznatkov - ale aj pri ďalšom riešení, návrhoch praktického využitia vybraných nástrojov controllingu v dopravných spoločnostiach. Predmetná problematika bola riešená s využitím vybraných kvalitatívnych metód, opierajúcich sa o indukciu so snahou pozorovať, zisťovať pravidelnosti, vytvárať závery a teórie za účelom získania naratívnych výstupov. Teoretické výstupy sú výsledkom spracovania dostupných poznatkov o controllingu a jeho vývoji, praktická rovina poskytuj výsledok vo forme návrhu uplatnenia vybraných nástrojov controllingu v podmienkach dopravných spoločností, pôsobiacich v Slovenskej republike. Príspevok možno považovať za relevantný zdroj poznania a pochopenia riešenej problematiky, ponúka metodický návrh, uplatniteľný vo všeobecnosti pre podniky, ktorých manažment sa pre zavádzanie a využívanie controllingových nástrojov rozhodne.
A Confession of Female Smokers in Medan about Their Smoking Habit (Cigarette and Chewing Tobacco): A Preliminary Study
Authors: Afriani Miskah , Binti Mohd Yusop Yuzana , Bin Muhamed Yusof Harmy 
Published: October 2020

Indonesia is the country with the highest number of smokers in ASEAN, with 65.19 million people. Equivalent is 34% of the total population of Indonesia in 2016. As 2545 women smoke, they smoke in various types, such as cigarettes, chewing tobacco, and vape (SDKI, 2018). Smoking prevalence among women is lower than that for men in most countries, but the rate is increasing rapidly from 4.2 percent to 6.7 percent in 2010-2013 (Riskesdas,2013).This research used qualitative approach. Semi-structured interviews were held with 47 individuals from Medan city. A purposive sample was used who self-identified as female smokers in the past 30-days. Most of the participants who volunteered to take part in the study were over 25 years old. Tobacco users are divided into two focal categories which are cigarette smokers and chewing tobacco addicts, 31 reported as cigarette smokers, and 16 were reported having a chewing tobacco habit. Researches categorized cigarette users or smokers as CU and chewing tobacco users as CTU. The analysis of transcripts from the interviews revealed five main themes: 1) Personal problem lead to smoking (CU) 2) School friends’ influences initiate the habit (CU) 3) Family tradition originate the chewing tobacco habit (CTU) 4) Prevent egoistic status from the tribe (CTU) and 5) Intent and struggle to quit but unsuccessful for CU but not CTU. Acclimatizing health promotion awareness and activities shall be concentrate on such as oral health, quit smoking and chewing tobacco program as well as motivational improvement approach to quit the smoking
Does Formalization of Informal Enterprises Matter? Evidence from Rwanda
Authors: Maniraguha Faustin 
Published: October 2020

In this decade, the formalization of informal sector is challenging as it provides jobs to the big number of the population and on the other hand, this group of active population work in conditions, which do not allow them to benefit some advantages from the government and these lead to not providing enough contribution to the economic growth. The main objective of the study was to find out the factors underlying for formalization of informal enterprises in Rwanda. In order to respond to the main objective, we used a desk research approach and we found that there is a necessity of enterprise formalization in Rwanda and the identified key factors are the enterprise motives/long term objectives, cash less economy/innovation in payment system and government policy for enterprise registration. The study also illustrated the factors or ways for private informal-rural enterprise formalization process may consider and some of them are affordable cost of taxation, accessibility to finance, accessibility to the markets as well as the time taken for getting legal documents. From the findings, the study recommend that the consistency capacity building so that to help managers to understand the necessity of informal sector formalization, government to continue working on the minimization of the costs related to the enterprise registration that include time, distance and other procedures and government also to continue enhancing infrastructures in rural zones. The study used secondary data both qualitative and quantitative from existing reports and data from National Institute of statistics of Rwanda.
Penerapan Perencanaan Pajak Penghasilan Pasal 21 Sebagai Upaya Penghematan Pph Badan Pada PT. Sang Hyang Seri (Persero) Cabang Sidrap
Authors: Yunus Muhammad 
Published: October 2020

Tujuan dari penelitian ini adalah untuk mengetahui penerapan perencanaan pajak (Tax Planning) untuk menghemat PPh badan dan mengetahui jumlah pajak terutang yang harus dibayar seteleh diterapkannya perencanaan pajak (Tax Planning) PT. Sang Hyang Seri (Persero) Cabang Sidrap. Penelitian ini menggunakan metode analisis data deskriptif kuantitatif tanpa menggunakan analisis statistik. Analisis data deskriptif kuantitatif merupakan penelitian yang spesifikasinya adalah sistematis, terencana, dan terstruktur dengan jelas sejak awal hingga pembuatan desain penelitiannya. Penelitian deskriptif kuantitatif ini juga menggunakan pendekatan dengan metode observasi dan dokumentasi ke pihak yang terkait dengan PT. Sang Hyang Seri (Persero) Cabang Sidrap. Hasil dari penelitian ini adalah dari tiga metode pemotongan PPh pasal 21 karyawan yaitu gross methode, net methode, dan gross up methode hanya metode gross up yang dapat menghemat PPh badan karena dapat dibiayakan sehingga tercipta suatu penghematan pajak. Strategi perpajakan ini juga akan menstimulasi karyawan untuk meningkatkan produktifitasnya atau meningkatkan kinerjanya karena pendapatan yang diperoleh lebih besar, jadi metode yang paling baik dilakukan dibandingkan metode lain yaitu gross up method (memberikan karyawan tunjangan pajak).
Prediksi Financial Distres Dengan Menggunakan Informasi Fundamental (Studi Pada Perusahaan Property Dan Real Estate Yang Terdaftar Di Bursa Efek Indonesia)
Authors: - Ramly , Razak Linda Arisanty , Sulaeha Sitti , Hasan Asriani 
Published: October 2020

Tujuan penelitian memprediksi financial distres dengan menggunakan informasi fundamental yaitu dengan menguji hubungan antara currrent ratio (CR), debt to equity ratio (DER), return on asset (ROA), inventory turnover (ITO) terhadap financial distres. Data yang digunakan merupakan data sekunder berupa laporan keuangan perusahaan mulai tahun 2014 hingga tahun 2018. Teknik perhitungan yang digunakan dalam penelitian ini adalah menggunakan metode Altman dan perhitungan rasio keuangan. Teknik analisis data yang digunakan dalam penelitian adalah analisis regresi linear berganda. Hasil penelitian menunjukkan variabel currrent ratio (CR), debt to equity ratio (DER), return on asset (ROA) memiliki hubungan yang signifikan terhadap financial distres sementara inventory turnover (ITO) memperoleh hasil yang tidak signifikan.
Fenomenologis Penerapan Akuntansi Dalam Rumah Tangga Pada Guru-Guru SMK Publik Makassar
Authors: Hasmi Nurlaila 
Published: October 2020

Every family has family financial management & acts as a manager, how each family will manage finances will be different, and usually the family finances will be fully regulated by the Housewife (wife). This research tries to reveal the role of teachers in Makassar Public Vocational School on how informants apply household accounting and manage their finances in the household on 4 (four) important things, namely: budgeting, recording, decision making and long-term planning. This study provides findings from a phenomenological study of accounting in the household.
This study aims to uncover family financial planning oriented to explore financial management in the families of teachers in Makassar Public Vocational Schools. The focus of discussion and observation is sought to answer the problem of teachers' understanding of the budget in family financial planning. The qualitative method used in this research uses the theoretical basis for the study of phenomenology. The results of the study it can be concluded that the importance of the role of accounting in the household to be able to plan every budget in the household, recording, decision making and long-term planning in the household. This will have a very good impact on controlling the financial cycle and to avoid misunderstandings between husband and wife, as well as the need for long-term decision making and planning in managing family finances better and more precisely.