bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging Challenges for Numerical Simulations of Quasi-Static Collision Experiments on Laser-Welded Thin-Walled Steel Structures
Authors: Romanoff Jani , Körgesaar Mihkel , Remes Heikki 
Published: December 2020

AbstractThis paper re-evaluates recently published quasi-static tests on laser-welded thin-walled steel structures in order to discuss the fundamental challenges in collision simulations based on finite element analysis. Clamped square panels were considered, with spherical indenter positioned at the mid-span of the stiffeners and moved along this centerline in order to change the load-carrying mechanism of the panels. Furthermore, the use of panels with single-sided flat bar stiffening and web-core sandwich panels enabled the investigation of the effect of structural topology on structural behavior and strength. The changes in loading position and panel topology resulted in different loading, structural and material gradients. In web-core panels, these three gradients occur at the same locations making the panel global responses sensitive for statistical variations and the failure process time-dependent. In stiffened panel with reduced structural gradient, this sensitivity and time-dependency in failure process is not observed. These observations set challenges to numerical simulations due to spatial and temporal discretization as well as the observed microrotation, which is beyond the currently used assumptions of classical continuum mechanics. Therefore, finally, we discuss the potential of non-classical continuum mechanics as remedy to deal with these phenomena and provide a base for necessary development for future.
Influencing factors for the digital transformation in the financial services sector
Authors: Werth Oliver , Schwarzbach Christoph , Rodríguez Cardona Davinia , Breitner Michael H. , Graf von der Schulenburg Johann-Matthias 
Published: December 2020

AbstractDigital transformation affects almost every area in societies and has consequences for incumbent companies. With qualitative research, we explore the influencing factors for digital transformation in the financial services sector. We use a PEST-model and Porter’s Five Forces as the underlying structure for our analysis. Our interviews and findings show that the financial services sector face the same current challenges, but their impact is perceived higher in the banking than in the insurance sector concerning social factors and bargaining power of buyers. The character of the current development is evolutionary rather than disruptive. Almost all incumbents currently focus on modernizing and consolidating their backend-systems. The aim is to enable them for new customer-oriented services. A primary driver for the digital transformation is the threat of a broader market entry by BigTechs. Our research provides a comprehensive overlook about the influencing factors of digital transformation using statements from experts in the field.
The Coronary Sinus Reducer; 5-year Dutch experience
Authors: Silvis M. J. M. , Dekker M. , Zivelonghi C. , Agostoni P. , Stella P. R. , Doevendans P. A. , de Kleijn D. P. V. , van Kuijk J. P. , Leenders G. E. , Timmers L. 
Published: December 2020

Abstract
Background
Refractory angina is a growing and major health-care problem affecting millions of patients with coronary artery disease worldwide. The Coronary Sinus Reducer (CSR) is a device that may be considered for the relief of symptoms of refractory angina. It causes increased venous pressure leading to a dilatation of arterioles and reduced arterial vascular resistance in the sub-endocardium. This study describes the 5‑year Dutch experience regarding safety and efficacy of the CSR.

Methods
One hundred and thirty-two patients with refractory angina were treated with the CSR. The primary efficacy endpoint of the study was Canadian Cardiovascular Society (CCS) class improvement between baseline and 6‑month follow-up. The primary safety endpoint was successful CSR implantation in the absence of any device-related events.

Results
Eighty-five patients (67%) showed improvement of at least 1 CCS class and 43 patients (34%) of at least 2 classes. Mean CCS class improved from 3.17 ± 0.61 to 2.12 ± 1.07 after implantation (P < 0.001). The CSR was successfully implanted in 99% of the patients and only minor complications during implantation were reported.

Conclusion
The CSR is a simple, safe, and effective option for most patients with refractory angina. However, approximately thirty percent of the patients showed no benefit after implantation. Future studies should focus on the exact underlying mechanisms of action and reasons for non-response to better identify patients that could benefit most from this therapy.
The future of sustainability in the context of COVID-19
Authors: Cawthorn Donna-Mareè , Kennaugh Alexandra , Ferreira Sam M. 
Published: December 2020

AbstractThe COVID-19 pandemic is a global crisis emanating both from a virus (SARS-CoV-2) and from the drastic actions to contain it. Here, we reflect on the immediate responses of most world powers amid the pandemic chaos: totalitarian surveillance and nationalist isolation. Drawing on published literature, we consider measures such as wildlife-use bans, lockdowns and travel restrictions, along with their reverberations for people, economies and the planet. Our synthesis highlights significant shortfalls of applying command-and-control tactics in emergencies. For one, heavy-handed bans risk enormous unintended consequences and tend to fail if they lack legitimacy or clash with people’s values. Furthermore, reactive and myopic strategies typically view the pandemic as a stand-alone crisis, rather than unravelling the complex interplay of nature-society interactions through which zoonotic diseases originate. A return to adaptive management approaches that recognise root causes and foster socio-ecological resilience will be essential to improve human and planetary health and mitigate future pandemics.
Repression of Polyol Pathway Activity by Hemidesmus indicus var. pubescens R.Br. Linn Root Extract, an Aldose Reductase Inhibitor: An In Silico and Ex Vivo Study
Authors: Haroon Hajira Banu , Perumalsamy Vijaybhanu , Nair Gouri , Anand Dhanusha Koppal , Kolli Rajitha , Monichen Joel , Prabha Kanchan 
Published: December 2020

Abstract
Development of diabetic cataract is mainly associated with the accumulation of sorbitol via the polyol pathway through the action of Aldose reductase (AR). Hence, AR inhibitors are considered as potential agents in the management of diabetic cataract. This study explored the AR inhibition potential of Hemidesmus indicus var. pubescens root extract by in silico and ex vivo methods. Molecular docking studies (Auto Dock tool) between β-sitosterol, hemidesminine, hemidesmin-1, hemidesmin-2, and AR showed that β-sitosterol (− 10.2 kcal/mol) and hemidesmin-2 (− 8.07 kcal/mol) had the strongest affinity to AR enzyme. Ex vivo studies were performed by incubating isolated goat lenses in artificial aqueous humor using galactose (55 mM) as cataract inducing agent at room temperature (pH 7.8) for 72 h. After treatment with Vitamin E acetate − 100 µg/mL (standard) and test extract (500 and 1000 µg/mL) separately, the estimation of biochemical markers showed inhibition of lens AR activity and decreased sorbitol levels. Additionally, extract also normalized the levels of antioxidant markers like SOD, CAT, GSH. Our results showed evidence that H. indicus var. pubescens root was able to prevent cataract by prevention of opacification and formation of polyols that underlines its potential as a possible therapeutic agent against diabetic complications.

Graphic Abstract
‘One size does not fit all’: The value of person-centred analysis in health professions education research
Authors: Kusurkar Rashmi A. , Mak-van der Vossen Marianne , Kors Joyce , Grijpma Jan-Willem , Van der Burgt Stéphanie M. E. , Koster Andries S. , De la Croix Anne 
Published: December 2020

Health professions education (HPE) research is dominated by variable-centred analysis, which enables the exploration of relationships between different independent and dependent variables in a study. Although the results of such analysis are interesting, an effort to conduct a more person-centred analysis in HPE research can help us in generating a more nuanced interpretation of the data on the variables involved in teaching and learning. The added value of using person-centred analysis, next to variable-centred analysis, lies in what it can bring to the applications of the research findings in educational practice. Research findings of person-centred analysis can facilitate the development of more personalized learning or remediation pathways and customization of teaching and supervision efforts. Making the research findings more recognizable in practice can make it easier for teachers and supervisors to understand and deal with students. The aim of this article is to compare and contrast different methods that can be used for person-centred analysis and show the incremental value of such analysis in HPE research. We describe three methods for conducting person-centred analysis: cluster, latent class and Q‑sort analyses, along with their advantages and disadvantage with three concrete examples for each method from HPE research studies.
A new class of high-entropy M3B4 borides
Authors: Qin Mingde , Yan Qizhang , Liu Yi , Luo Jian 
Published: December 2020

AbstractA new class of high-entropy M3B4 borides of the Ta3B4-prototyped orthorhombic structure has been synthesized in the bulk form for the first time. Specimens with compositions of (V0.2Cr0.2Nb0.2Mo0.2Ta0.2)3B4 and (V0.2Cr0.2Nb0.2Ta0.2W0.2)3B4 were fabricated via reactive spark plasma sintering of high-energy-ball-milled elemental boron and metal precursors. The sintered specimens were ∼98.7% in relative densities with virtually no oxide contamination, albeit the presence of minor (4–5 vol%) secondary high-entropy M5B6 phases. Despite that Mo3B4 or W3B4 are not stable phase, 20% of Mo3B4 and W3B4 can be stabilized into the high-entropy M3B4 borides. Vickers hardness was measured to be 18.6 and 19.8 GPa at a standard load of 9.8 N. This work has further expanded the family of different structures of high-entropy ceramics reported to date.
Prediction and analysis of human‐herpes simplex virus type 1 protein‐protein interactions by integrating multiple methods
Authors: Lian Xianyi , Yang Xiaodi , Shao Jiqi , Hou Fujun , Yang Shiping , Pan Dongli , Zhang Ziding 
Published: December 2020

BackgroundHerpes simplex virus type 1 (HSV‐1) is a ubiquitous infectious pathogen that widely affects human health. To decipher the complicated human‐HSV‐1 interactions, a comprehensive protein‐protein interaction (PPI) network between human and HSV‐1 is highly demanded.MethodsTo complement the experimental identification of human‐HSV‐1 PPIs, an integrative strategy to predict proteome‐wide PPIs between human and HSV‐1 was developed. For each human‐HSV‐1 protein pair, four popular PPI inference methods, including interolog mapping, the domain‐domain interaction‐based method, the domain‐motif interaction‐based method, and the machine learning‐based method, were optimally implemented to generate four interaction probability scores, which were further integrated into a final probability score.ResultsAs a result, a comprehensive high‐confidence PPI network between human and HSV‐1 was established, covering 10,432 interactions between 4,546 human proteins and 72 HSV‐1 proteins. Functional and network analyses of the HSV‐1 targeting proteins in the context of human interactome can recapitulate the known knowledge regarding the HSV‐1 replication cycle, supporting the overall reliability of the predicted PPI network. Considering that HSV‐1 infections are implicated in encephalitis and neurodegenerative diseases, we focused on exploring the biological significance of the brain‐specific human‐HSV‐1 PPIs. In particular, the predicted interactions between HSV‐1 proteins and Alzheimer’s‐disease‐related proteins were intensively investigated.ConclusionThe current work can provide testable hypotheses to assist in the mechanistic understanding of the human‐HSV‐1 relationship and the anti‐HSV‐1 pharmaceutical target discovery. To make the predicted PPI network and the datasets freely accessible to the scientific community, a user‐friendly database browser was released at http://www.zzdlab.com/HintHSV/index.php.
How to Do Things With Texts: A Functional Account of Reading Comprehension
Authors: Flores Eileen Pfeiffer , de Oliveira-Castro Jorge Mendes , de Souza Carlos Barbosa Alves 
Published: December 2020

AbstractWe offer an account of reading comprehension that we believe will help clarify some common conceptual confusions in the relevant literature, as well as contribute to existing functional accounts. We argue that defining texts qua texts as stimulus classes, on the one hand, and equating “comprehension” with behavior (covert or otherwise), on the other, are not useful conceptual moves, especially when behavioral settings go beyond basic literacy skills acquisition. We then analyze the structure of the contingencies that usually evoke talk of “comprehension” using techniques from analytic philosophy. We show how keeping the results of this analysis in mind can help avoid the conceptual bafflement that often arises, even among behavior analysts, when defining or assessing behavioral phenomena related to reading comprehension. Using two contrasting cases (legal texts and stories), we argue that what counts as comprehension depends, not peripherally but crucially, on the shared social practices of which texts are a part. Finally, we propose a new framework for classifying reader–text contingencies by combining two dimensions: openness of setting and embeddedness of reinforcement.
10-Year Survival after Breast-Conserving Surgery Compared with Mastectomy in Louisiana Women with Early-Stage Breast Cancer: A Population-Based Study
Authors: Chu Quyen D. , Hsieh Mei-Chin , Lyons John M. , Wu Xiao-Cheng 
Published: December 2020

BACKGROUND:
Louisiana has the third highest breast cancer mortality in the US, despite ranking 30th in incidence. Whether surgical approach contributes to such a poor outcome is unknown. We compared outcomes of breast-conserving surgery plus radiation (BCT) vs mastectomy (MST) for Louisiana women with early-stage breast cancer.

STUDY DESIGN:
Data on women diagnosed with Stage I–II breast cancer from 2004 to 2016 were analyzed from the Louisiana Tumor Registry. Overall survival (OS) and breast cancer-specific survival (CSS) were compared between BCT and MST. Kaplan-Meier method and log-rank test were used to compare survival curves, and logistic regression was used to examine the association of sociodemographic and clinical factors with the type of breast cancer surgery. Values of p < 0.05 were considered significant.

RESULTS:
Of the 18,260 patients, 9,968 patients (54.6%) had BCT and 8,292 patients (45.4%) had MST. Compared with BCT, the MST group tended to be underinsured/Medicare/Medicaid, more impoverished, had higher stage 2 disease, were more likely to reside in rural regions, travel ≥25 miles to radiation treatment facility, be treated at low volume centers, and have T3, node positive, and poorly differentiated tumors. Ten-year OS and CSS were significantly better among those who had BCT (OS: 80.0%; 95% CI: 79.0%–81.1%; CSS: 92.7%; 95% CI: 92.1%–93.4%) than those having MST (OS: 69.3%; 95% CI: 68.0%–70.5%; CSS: 88.8%:95% CI: 87.9%–89.7%) (p < 0.05). Even after controlling for sociodemographic and clinical variables, MST was associated with a 28.6% increased risk of death from all causes (hazard ratio [HR]:1.286; 95% CI:1.197–1.380) and a 29.8% increased risk of breast-cancer specific death (HR:1.298; 95% CI: 1.150–1.465).

CONCLUSIONS:
Surgical approach, a factor that is within the control of the surgeon, has an impact on mortality for Louisiana women with early-stage breast cancer.
Off-farm Income, Credit Constraints, and Farm Investment
Authors: Key Nigel 
Published: December 2020

AbstractMany farmers face borrowing limits that depend on their household income and net worth. Given such credit constraints, an increase in off-farm income should allow farmers to borrow more, thus influencing production decisions and productivity. To test this hypothesis, the education level of the farm operator’s spouse is used to identify exogenous variation in off-farm income. Findings indicate that higher off-farm income leads to more borrowing, capital expenditures, capital input intensity, farm labor use, output, farm income, and productivity. Results suggest that Federal programs that promote access to credit for limited-resource farmers may increase farm investment and productivity.
Descartes on the Animal Within, and the Animals Without
Authors: Thomas Evan 
Published: December 2020

AbstractDescartes held that animals are material automata without minds. However, this raises a puzzle. Descartes’s argument for this doctrine relies on the claims that animals lack language and general intelligence. But these claims seem compatible with the view that animals have minds. As a solution to this puzzle, I defend what I call theintrospective-analogicalinterpretation. According to this interpretation, Descartes employs introspection to show that certain human behaviors do not depend on thought but rather on automatic bodily processes. Descartes then argues that animal behavior resembles only those behaviors that are automatic in humans. Analogy thus supports the view that the behaviors of animals do not depend on thought but are, rather, automatic. And if animal behavior is automatic, then animals are best regarded as automata.
Dynamics of plane partitions: Proof of the Cameron–Fon-Der-Flaass conjecture
Authors: Patrias Rebecca , Pechenik Oliver 
Published: December 2020

AbstractOne of the oldest outstanding problems in dynamical algebraic combinatorics is the following conjecture of P. Cameron and D. Fon-Der-Flaass (1995): consider a plane partitionPin an$a \times b \times c$box${\sf B}$. Let$\Psi (P)$denote the smallest plane partition containing the minimal elements of${\sf B} - P$. Then if$p= a+b+c-1$is prime, Cameron and Fon-Der-Flaass conjectured that the cardinality of the$\Psi $-orbit ofPis always a multiple ofp.This conjecture was established for$p \gg 0$by Cameron and Fon-Der-Flaass (1995) and for slightly smaller values ofpin work of K. Dilks, J. Striker and the second author (2017). Our main theorem specializes to prove this conjecture in full generality.
Infection control challenges in setting up community isolation and treatment facilities for patients with coronavirus disease 2019 (COVID-19): Implementation of directly observed environmental disinfection
Authors: Wong Shuk-Ching , Leung Ming , Tong Danny Wah-Kun , Lee Larry Lap-Yip , Leung Will Lok-Hang , Chan Frank Wan-Kin , Chen Jonathan Hon-Kwan , Hung Ivan Fan-Ngai , Yuen Kwok-Yung , Yeung Deacons Tai-Kong , Chung Kin-Lai , Cheng Vincent Chi-Chung 
Published: December 2020

AbstractBackground:Extensive environmental contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported in hospitals during the coronavirus disease 2019 (COVID-19) pandemic. We report our experience with the practice of directly observed environmental disinfection (DOED) in a community isolation facility (CIF) and a community treatment facility (CTF) in Hong Kong.Methods:The CIF, with 250 single-room bungalows in a holiday camp, opened on July 24, 2020, to receive step-down patients from hospitals. The CTF, with 500 beds in open cubicles inside a convention hall, was activated on August 1, 2020, to admit newly diagnosed COVID-19 patients from the community. Healthcare workers (HCWs) and cleaning staff received infection control training to reinforce donning and doffing of personal protective equipment and to understand the practice of DOED, in which the cleaning staff observed patient and staff activities and then performed environmental disinfection immediately thereafter. Supervisors also observed cleaning staff to ensure the quality of work. In the CTF, air and environmental samples were collected on days 7, 14, 21, and 28 for SARS-CoV-2 detection by RT-PCR. Patient compliance with mask wearing was also recorded.Results:Of 291 HCWs and 54 cleaning staff who managed 243 patients in the CIF and 674 patients in the CTF from July 24 to August 29, 2020, no one acquired COVID-19. All 24 air samples and 520 environmental samples collected in the patient area of the CTF were negative for SARS-CoV-2. Patient compliance with mask wearing was 100%.Conclusion:With appropriate infection control measures, zero environmental contamination and nosocomial transmission of SARS-CoV-2 to HCWs and cleaning staff was achieved.
Drygalski Ice Tongue stability influenced by rift formation and ice morphology
Authors: Indrigo Christine , Dow Christine F. , Greenbaum Jamin S. , Morlighem Mathieu 
Published: December 2020

AbstractThe Drygalski Ice Tongue in East Antarctica stretches 90 km into the Ross Sea and influences the local ocean circulation, and persistence of the Terra Nova Bay Polynya. We examine the controls on the size of this floating ice body by comparing the propagation of six large fractures on the ice tongue's northern side using 21 years of Landsat imagery with hydrostatic ice thickness maps and strain rate calculations. We also apply a subglacial hydrology model to estimate the location and discharge from subglacial channels over the grounding line and compare these with basal channels identified along the ice tongue using remote sensing and airborne radar data. Our results suggest that large fractures are inhibited from full-width propagation by thicker ice between basal channels. We hypothesize that only once the ice tongue thins towards the terminus, can fractures propagate and cause large calving events. This suggests an important relationship between the melting of floating ice from subglacial and ocean sources and the expansion of fractures that lead to ice tongue calving.
MORAL INNOCENCE AND THE CRIMINAL LAW: NON-MALA ACTIONS AND NON-CULPABLE AGENTS
Authors: Segev Re'em 
Published: December 2020

AbstractAccording to an influential view, using the criminal law against innocent actions or agents is wrong. In this paper, I consider four related arguments against this view: a debunking argument that suggests that the intuitive appeal of this view may be due to a conflation of different ideas; a counterexamples argument that points out that there are many cases in which using the criminal law against innocent actions or agents is justified; a theoretical argument, according to which the force of the reasons for and against using the criminal law is a matter of degree and it is therefore implausible to hold that the latter always defeat the former; and an analogy argument, which holds that it is implausible to maintain that harming innocents is often justified in other contexts but (almost) never in the context of the criminal law.
Where Does the Predictability from Sorting on Returns of Economically Linked Firms Come From?
Authors: Burt Aaron , Hrdlicka Christopher 
Published: December 2020

AbstractCross-firm predictability among economically linked firms can arise when both firms exhibit their own momentum and their returns are contemporaneously correlated. We show that cross-firm predictability can last up to 10 years, which is hard to reconcile with an interpretation of slow information diffusion. However, it is consistent with the economically linked firms’ commonality in momentum. The contribution of each source can be found by decomposing leaders’ returns into the predictable (momentum) and news components. Sorting on each, we find that both sources contribute almost equally to 1-month predictability, whereas commonality in momentum is solely responsible for longer-horizon cross-firm predictability.