bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Protective Effect of Rosavin from Rhodiola rosea on Radiation‐Induced Intestinal Injury
Authors: Zhou Weijie , Chen Kequan , Lu Quan , Luo Yujun , Zhang Chen , Zheng Yue , Zhuo Zewei , Guo Kehang , Wang Jinghua , Chen Hao , Sha Weihong 
Published: October 2020

AbstractBioactive constituents from Rhodiola rosea L. (RRL) exhibit multiple pharmacological effects on diverse diseases. However, whether they are suitable for the treatment of radiation‐induced intestinal injury (RIII) remains unclear. This study aims to investigate their roles and mechanisms in the RIII rat model. The radioprotective effects of the four bioactive constituents of RRL (salidroside, herbacetin, rosavin and arbutin) were evaluated by the cell viability of irradiated IEC‐6 cells. Intestinal tissues were collected for histological analysis, localized inflammation and oxidative stress assessments. Our work showed that salidroside, rosavin and arbutin improved the cell viability of the irradiated IEC‐6 cells, with the highest improvement in 12.5 μM rosavin group. The rosavin treatment significantly improved survival rate and intestinal damage in irradiated rats by modulating the inflammatory response and oxidative stress. Our work indicated that rosavin may be the optimal constituent of RRL for RIII treatment, providing an attractive candidate for radioprotection.
Delayed awakening from general anesthesia revealing Fahr syndrome: Case report and literature review
Authors: Mellagui Yassine , Aabdi Mohammed , Ouachaou Jamal , Bkiyar Houssam , Housni Brahim 
Published: October 2020

AbstractFahr syndrome (FS) is defined by the presence of bilateral and symmetrical intracerebral nonarteriosclerotic calcifications, localized in the central gray nuclei. We report the case of a patient who presented a postoperative delay in awakening and whose biological and radiological investigations revealed a FS.
Insights into the Nature of Self‐Extinguishing External Donors for Ziegler‐Natta Catalysis: A Combined Experimental and DFT Study
Authors: Vipin Raj K. , Kumawat Jugal , Dhamaniya Sunil , Subaramanian Murugan , Balaraman Ekambaram , Kumar Gupta Virendra , Vanka Kumar , Grubbs Robert H. 
Published: October 2020

AbstractDeveloping donors for Ziegler‐Natta (ZN) catalysis to control the polymerization reaction and produce polymers with desirable properties has always been challenging due to the multi‐component nature of the catalytic systems. Here, we have developed a new synthetic protocol for making two external donors, D1 (2,2,2‐trifluoroethyl myristate) and D2 (2,2,2‐trifluoroethyl palmitate) that show self‐extinguishing properties, followed by a systematic DFT study to understand this peculiar property of these donors. D1 and D2 can undergo parallel reactions with aluminum and titanium species present in the system to produce ketones and aldehydes, which are poisons for ZN catalytic systems, thus explaining their self‐extinguishing nature. The non‐covalent interaction between the long alkyl chain of the donors with the surface plays a vital role in determining the donors′ self‐extinguishing nature. There is a significant thermodynamic preference for the binding of the donor with the longer alkyl chain at the titanium center. The current work, therefore, provides interesting insights into how self‐extinguishing donors function in ZN catalytic systems.
Curvature‐induced Zn 3d Electron Return on Zn−N4 Single‐atom Carbon Nanofibers for Boosting Electroreduction of CO2
Authors: Fang Mingwei , Wang Xingpu , Li Xueyan , Zhu Ying , Xiao Guozheng , Feng Jingjing , Jiang Xiaohui , Lv Kuilin , Zhu Ying , Lin Wen‐Feng 
Published: October 2020

AbstractThe electrochemical CO2 reduction to desired chemical feedstocks is of importance, yet it is still challenging to obtain high production selectivity with low overpotential at a current density surpassing the industry benchmark of 100 mA cm−2. Herein, we constructed a low‐cost Zn single‐atom anchored on curved N‐doped carbon nanofibers (Zn SAs/N−C) by a facile noncovalent self‐assembly approach. At a low overpotential of only 330 mV, the Zn SAs/N−C exhibited simultaneously both a high current density up to 121.5 mA cm−2 and a CO FE of 94.7 %, superior to the previous reports. Experiments and DFT calculations revealed that the Zn atoms in Zn−N4 acted as the active sites, while adjacent pyridine‐N coupled with Zn−N4 could synergistically decrease the free energy barrier for intermediate *COOH formation. Importantly, the curvature of catalyst induced Zn 3d electrons that were bound to the Zn−N bonds to return to Zn atom, thereby leading to an increase in electron density of Zn and accelerating CO2 electroreduction to CO.
An analysis of HER2 amplification in cervical adenocarcinoma: correlation with clinical outcomes and the International Endocervical Adenocarcinoma Criteria and Classification
Authors: Shi Haiyan , Shao Ying , Lu Weiguo , Lu Bingjian 
Published: October 2020

AbstractFew studies have explored HER2 status in cervical adenocarcinoma, particularly in the gastric‐type adenocarcinoma (GAC), a nonhuman‐papillomavirus‐related subtype with poor clinical outcomes. In this study, we investigated HER2 expression and amplification by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) in 209 well annotated cervical adenocarcinomas diagnosed using the International Endocervical Adenocarcinoma Criteria and Classification. IHC identified HER2 protein expression in 57.4% (123/209) of adenocarcinomas, of which 62 were IHC 1+ (negative), 38 2+ (equivocal) and 23 3+ (positive). HER2 amplification was found in 13 cases (6.2%) including 10 with IHC 3+ and 3 with IHC 2+. Among all the major histotypes of cervical adenocarcinoma, HER2 amplification was most common in GAC cases with a frequency of 14.7% (5/34). Moreover, HER2 amplification was more frequently associated with 2018 International Federation of Gynecology & Obstetrics (FIGO) stage III/IV, perineural involvement and ovarian spread (p < 0.05) while IHC 3+ was more common in patients with lymphovascular invasion and ovarian involvement (p < 0.05). Survival analysis indicated that FIGO stage III/IV, GAC, and p53 overexpression were associated with poor disease‐specific survival and tumor recurrence (p < 0.05). In conclusion, HER2 amplification was present in a subset of adenocarcinomas, and more common in GAC, pointing to a potential benefit from trastuzumab treatment. HER2 overexpression does not identify gene amplification status in cervical adenocarcinoma; therefore, FISH is suggested for both IHC positive and equivocal cases. Further investigation on more cases with longer follow‐up times is required to consolidate these findings.
Practice pattern of use of high sensitivity troponin in the outpatient settings
Authors: Ferro Enrico G. , Bhatt Ankeet S. , Zhou Guohai , Fiumara Karen , Wasfy Jason H. , Sequist Thomas D. , Morrow David A. , Scirica Benjamin M. 
Published: October 2020

AbstractBackgroundHigh‐sensitivity troponin assays (hs‐Tn) detect lower serum concentrations than prior‐generation assays and help guide acute coronary syndrome (ACS) evaluation in emergency departments. Outpatient hs‐Tn utilization is not well described.HypothesisOutpatient providers use hs‐TnT to triage patients with suspected ACS.MethodsWe compared the volume of outpatient prior‐generation troponin tests in the pre‐hsTn implementation period (January 2015‐March 2018) with outpatient hs‐TnT volume in the post‐implementation period (April 2018‐January 2020). Triage patterns were compared between patients with hs‐TnT≥99th vs <99th percentile, using two‐sample t tests. In patients triaged home, adverse events were compared between patients with hs‐TnT≥99th vs <99th percentile, using log‐rank tests.ResultsAcross a large tertiary healthcare system, a mean of 80 prior‐generation tests/month were ordered during the pre‐hsTn implementation period compared with 12 hs‐TnT tests/month in the post‐implementation period. Prior‐generation orders rose by 1.72 tests/month during pre‐implementation, vs a decline of 2.74 hs‐TnT tests/month during post‐implementation (P < .001). Among 129 hs‐TnT orders, most were placed by cardiologists (54%) and primary care providers (32%). Patient symptoms at the time of troponin ordering included dyspnea (34%) and chest pain (33%), although 25% were asymptomatic. Among symptomatic patients (n = 74), those with hs‐TnT > 99th percentile were more likely to be sent to the ED (RR, 3.36; 95% CI, 1.22‐9.25; P = .002). Among patients sent home (n = 66), those with hs‐TnT > 99th percentile had more adverse events by 6 months (3.3% vs 22.2% RR, 6.67; 95% CI, 1.04‐42.9; P = .026).ConclusionsIn this healthcare system, outpatient troponin utilization significantly declined since hs‐TnT implementation. Some providers use hs‐TnT to triage patients with suspected ACS to the ED; others test asymptomatic patients and some send patients home despite high hs‐TnT values.
γ‐Non‐Symmetrically Dimasked TriPPPro Prodrugs as Potential Antiviral Agents against HIV
Authors: Zhao Chenglong , Jia Xiao , Schols Dominique , Balzarini Jan , Meier Chris 
Published: October 2020

AbstractNucleoside analogue reverse transcriptase inhibitors (NRTI) and nucleoside analogue monophosphate prodrugs are used in combination antiretroviral therapy (cART). The design of antivirally active nucleoside triphosphate prodrugs is a recent and an important advancement in the field of nucleoside analogue drug development. Here, we report on TriPPPro‐derivatives of nucleoside analogue triphosphates (NTPs) that comprised two different acyloxybenzyl‐masks at the γ‐phosphate of the NTP aiming to achieve the metabolic bypass. Thus, γ‐non‐symmetrically dimasked TriPPPro‐compounds (γ‐(AB,ab)‐d4TTPs) were synthesized and they proved to be active against HIV‐1 and HIV‐2 in cultures of infected wild‐type human CD4+ T‐lymphocyte (CEM/0) cells and more importantly also in thymidine kinase‐deficient CD4+ T‐cells (CEM/TK‐). From hydrolysis studies both in phosphate buffer (PB, pH 7.3) and CEM cell extracts, there was surprisingly no differentiation in the cleavage of the two acyloxybenzyl prodrug‐masks. However, if within one of the two acyloxybenzyl groups a short PEG‐type methoxytriglycol group was introduced, the “standard” acyloxybenzyl‐mask was cleaved with high preference.
Single‐Atom and Dual‐Atom Electrocatalysts Derived from Metal Organic Frameworks: Current Progress and Perspectives
Authors: Chen Siru , Cui Ming , Yin Zehao , Xiong Jiabin , Mi Liwei , Li Yanqiang 
Published: October 2020

AbstractSingle‐atom catalysts (SACs) have attracted increasing research interests owing to their unique electronic structures, quantum size effects and maximum utilization rate of atoms. Metal organic frameworks (MOFs) are good candidates to prepare SACs owing to the atomically dispersed metal nodes in MOFs and abundant N and C species to stabilize the single atoms. In addition, the distance of adjacent metal atoms can be turned by adjusting the size of ligands and adding volatile metal centers to promote the formation of isolated metal atoms. Moreover, the diverse metal centers in MOFs can promote the preparation of dual‐atom catalysts (DACs) to improve the metal loading and optimize the electronic structures of the catalysts. The applications of MOFs derived SACs and DACs for electrocatalysis, including oxygen reduction reaction, oxygen evolution reaction, hydrogen evolution reaction, carbon dioxide reduction reaction and nitrogen reduction reaction are systematically summarized in this Review. The corresponding synthesis strategies, atomic structures and electrocatalytic performances of the catalysts are discussed to provide a deep understanding of MOFs‐based atomic electrocatalysts. The catalytic mechanisms of the catalysts are presented, and the crucial challenges and perspectives are proposed to promote further design and applications of atomic electrocatalysts.
Microvessel‐Assisted Environmental Thermal Energy Extraction Enabling 24‐Hour Continuous Interfacial Vapor Generation
Authors: Xu Yuxia , Xu Ting , Wang Jiaying , Liu Weiping , Wang Juan 
Published: October 2020

AbstractAbstract: Interfacial solar evaporators have great potential for clean water production; however, their evaporation performance relies greatly on the solar illumination condition, which is restricted by daily sunshine time and climates. Here, a wood‐based vapor generator in pyramid structure is fabricated to achieve efficient water evaporation under dark condition (0 kW m−2) through efficient extraction of environmental thermal energy. The microvessels of wood provide fast water transportation whereas the tailored pyramid surface structure enables efficient evaporative cooling for extracting energy from the environment. The method enables fast water evaporation without the need of solar heat input. We demonstrate a vapor generation rate of up to 2.15 kg m−2 h−1 under dark condition (0 kW m−2), which is even 1.4 times faster than the theoretical limit of conventional solar thermal evaporators working under 1 sun (1 kW m−2) illumination condition. During the 24‐h continuous evaporation test, the evaporator presented a daily vapor generation rate of up to 50.8 kg m−2 day−1 and 60.7 kg m−2 day−1 on cloudy and sunny day, respectively, offering a novel approach for the development of 24‐h full‐time water evaporators for seawater desalination and wastewater treatment.
Measuring nestedness: A comparative study of the performance of different metrics
Authors: Payrató‐Borràs Clàudia , Hernández Laura , Moreno Yamir 
Published: October 2020

AbstractNestedness is a property of interaction networks widely observed in natural mutualistic communities, among other systems. A perfectly nested network is characterized by the peculiarity that the interactions of any node form a subset of the interactions of all nodes with higher degree. Despite a widespread interest on this pattern, no general consensus exists on how to measure it. Instead, several nestedness metrics, based on different but not necessarily independent properties of the networks, coexist in the literature, blurring the comparison between ecosystems. In this work, we present a detailed critical study of the behavior of six nestedness metrics and the variants of two of them. In order to evaluate their performance, we compare the obtained values of the nestedness of a large set of real networks among them and against a maximum‐entropy and maximum‐likelihood null model. We also analyze the dependencies of each metrics on different network parameters, as size, fill, and eccentricity. Our results point out, first, that the metrics do not rank networks universally in terms of their degree of nestedness. Furthermore, several metrics show significant dependencies on the network properties considered. The study of these dependencies allows us to understand some of the observed systematic shifts against the null model. Altogether, this paper intends to provide readers with a critical guide on how to measure nestedness patterns, by explaining the functioning of several metrics and disclosing their qualities and flaws. Besides, we also aim to extend the application of null models based on maximum entropy to the scarcely explored area of ecological networks. Finally, we provide a fully documented repository that allows constructing the null model and calculating the studied nestedness indexes. In addition, it provides the probability matrices to build the null model for a large dataset of more than 200 bipartite networks.
The role of intraspecific competition between plants in a nursery pollination system—Comments on Villacañas de Castro and Hoffmeister 2020
Authors: Gutiérrez Nicolas M. , Stucchi Luciano , Galeano Javier , Giménez‐Benavides Luis 
Published: October 2020

AbstractWe present comments on an article published by Villacañas de Castro and Hoffmeister (Ecology and Evolution, 10, 4220; 2020). The authors studied a tritrophic system composed of a plant, its pollinating seed predator, and a parasitoid of the latter. Their concern was whether the parasitoid modifies the interaction between the plant and its pollinator–herbivore along the mutualism–antagonism gradient, but they reduced their question to how the parasitoid impacts plant fitness. After showing that the parasitoid increases seed output of the plant by decreasing the amount of seeds consumed by the pollinating seed predator, they tested whether seed output is a good proxy for plant fitness. They argue that it is not by showing that the increased seed density has a negative impact on survival probability and flower production, likely due to plant intraspecific competition. The work presented shows careful experimentation and interesting results, but we do not share some of their conclusions. Most importantly, we believe that the net effect of the parasitoid on the plant–herbivore interaction cannot be adequately investigated by focusing on individual plant fitness. Thus, we first suggest considering the number of surviving plants up to adulthood as a proxy for population performance to address this question. Using this proxy, we show that the increase in seed output due to the parasitoid is beneficial to the plant population until its carrying capacity is achieved. Next, using a population dynamics model, we show under which particular conditions the negative effect of intraspecific competition outweighs the positive effect of seed density increase (due to parasitoid's defense). When these conditions do not hold, the role of plant intraspecific competition is basically limited to the prevention of unbounded population growth, while the parasitoid increases the plant's equilibrium density above its carrying capacity as measured when interacting only with the pollinating seed predator, thus making the system more stable.
Synthesis of silver nanoparticle from X‐ray film and its application in production of biofuel from jatropha oil
Authors: Ganesan Ramya , Narasimhalu Padmamalini , Joseph Amala Infant Joice , Pugazhendhi Arivalagan 
Published: October 2020

SummaryRecycling of waste material and production of biofuels are the thrust areas to modern technology. The basic idea behind this work is to regenerate waste silver from X‐ray films and to employ them in biofuel production from jatropha oil. Stable silver nanoparticles (Ag NPs) were prepared using Quercus infectoria (oak gall) and raw Camellia sinensis (tea) extracts. The synthesized materials were characterized by XRD, UV‐visible spectra, energy‐dispersive X‐ray analysis, and Fe‐SEM technique. The temperature of the reactions, weight hourly space velocity, and time of reaction decide the yield of biofuel, and the parameters were optimized over Ag NP catalyst. Apart from yield of biofuel, the proportion of gasoline fraction (C5‐C9) was also peer monitored. A maximum of 90% conversion of jatropha oil was converted into 85% biofuel with 76% selectivity toward gasoline over Ag NPs. Flash point, fire point, calorific value, cloud point, specific gravity, and viscosity of the gasoline were evaluated and correlated with ASTM D6751 standards.
The Combined Effects of Road Salt and Biotic Stressors on Amphibian Sex Ratios
Authors: Leggett Sagan , Borrelli Jonathan , Jones Devin K. , Relyea Rick 
Published: October 2020

Abstract
Aquatic systems worldwide are threatened by the anthropogenic use of synthetic chemicals, including pesticides, pharmaceuticals, and road de-icers. Exposure to contaminants can alter the behavior, morphology, and physiology of organisms if it occurs during sensitive life stages. For instance, past studies have documented feminization of male amphibians following herbicide exposure and skewed sex ratios among amphibian populations exposed to road salt. However, many of these studies lack the complexities found within natural environments, such as competition with conspecifics or threat of predation, which are also known to influence development. Thus, it is important to understand how anthropogenic and natural stressors interact to alter animal sex ratios. Given the growing concern of secondary salinization of freshwater systems, we exposed larval wood frogs (Rana sylvatica) to either road salt (sodium chloride [NaCl]) or an alternative salt mixture (NaCl, magnesium chloride [MgCl2], and potassium chloride [KCl]) at 3 concentrations (200, 600, and 1000 mg Cl−/L) crossed with 3 biotic stressors (no-stressor control, competition, or predator cues) to examine their potentially interactive effects on sex. Exposure to biotic stressors and NaCl did not influence wood frog sex ratios. In contrast, tadpole exposure to the intermediate salt mixture concentration significantly reduced the proportion of female frogs. Future studies are needed to determine whether such changes in sex are widespread among sensitive species with complex life cycles, and to assess the consequences of sex ratio changes on long-term population dynamics. Environ Toxicol Chem 2021;40:231–235. © 2020 SETAC
Advances in understanding of health‐promoting benefits of medicine and food homology using analysis of gut microbiota and metabolomics
Authors: Yang Minmin , Yan Tao , Yu Meng , Kang Jie , Gao Ruoxi , Wang Peng , Zhang Yuhuan , Zhang Huafeng , Shi Lin 
Published: October 2020

AbstractThe health‐promoting benefits of medicine and food homology (MFH) are known for thousands of years in China. However, active compounds and biological mechanisms are unclear, greatly limiting clinical practice of MFH. The advent of gut microbiota analysis and metabolomics emerge as key tools to discover functional compounds, therapeutic targets, and mechanisms of benefits of MFH. Such studies hold great promise to promote and optimize functional efficacy and development of MFH‐based products, for example, foods for daily dietary supplements or for special medical purposes. In this review, we summarized pharmacological effects of 109 species of MFH approved by the Health and Fitness Commission in 2015. Recent studies applying genome sequencing of gut microbiota and metabolomics to explain the activity of MFH in prevention and management of health consequences were extensively reviewed. We discussed the potentiality in future to decipher functional activities of MFH by applying metabolomics‐based polypharmacokinetic strategy and multiomics technologies. The needs for personalized MFH recommendations and comprehensive databases have also been highlighted. This review emphasizes current achievements and challenges of the analysis of gut microbiota and metabolomics as a new avenue to understand MFH.