bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temperature and photoperiod effects on dormancy status and life cycle parameters in Aedes albopictus and Aedes aegypti from subtropical Argentina
Authors: Garzón M. J. , Maffey L. , Lizuain A. , Soto D. , Diaz P. C. , Leporace M. , Salomón O. D. , Schweigmann N. J. 
Published: August 2020

AbstractAedes albopictus (Diptera: Culicidae) distribution is bounded to a subtropical area in Argentina, while Aedes aegypti (Diptera: Culicidae) covers both temperate and subtropical regions. We assessed thermal and photoperiod conditions on dormancy status, development time and mortality for these species from subtropical Argentina. Short days (8 light : 16 dark) significantly increased larval development time for both species, an effect previously linked to diapause incidence. Aedes albopictus showed higher mortality than Ae. aegypti at 16 °C under long day treatments (16 light : 8 dark), which could indicate a lower tolerance to a sudden temperature decrease during the summer season. Aedes albopictus showed a slightly higher percentage of dormant eggs from females exposed to a short day, relative to previous research in Brazilian populations. Since we employed more hours of darkness, this could suggest a relationship between day‐length and dormancy intensity. Interestingly, local Ae. aegypti presented dormancy similar to Ae. albopictus, in accordance with temperate populations. The minimum dormancy in Ae. albopictus would not be sufficient to extend its bounded distribution. We believe that these findings represent a novel contribution to current knowledge about the ecophysiology of Ae. albopictus and Ae. aegypti, two species with great epidemiological relevance in this subtropical region.
Perspectives on blood pressure by patients on haemo‐ and peritoneal dialysis
Authors: Evangelidis Nicole , Sautenet Benedicte , Manera Karine E. , Howell Martin , Craig Jonathan C. , Viecelli Andrea K. , O'Lone Emma , Scholes‐Robertson Nicole , Johnson David W. , Cho Yeoungjee , Tomson Charles , Wheeler David C. , Tong Allison ,   for the SONG‐HD and SONG‐PD initiative
Published: August 2020

AbstractAimThe management of blood pressure in patients requiring dialysis remains challenging and controversial. This study aimed to describe the perspectives of patients treated with peritoneal or haemodialysis regarding blood pressure, to inform patient‐centred management.MethodsWe conducted a secondary thematic analysis of qualitative data from multiple data sets derived from the Standardised Outcomes in Nephrology (SONG) initiative. We extracted and analysed the responses of adult patients (aged 18 years or over) on haemodialysis and peritoneal dialysis, and their caregivers. Qualitative data were extracted from 26 focus groups, two international Delphi surveys and two consensus workshops completed as part of the SONG‐Haemodialysis and SONG‐Peritoneal dialysis projects.ResultsCollectively, the studies involved 644 patients and caregivers from 86 countries. We identified four themes: helpless and incapacitated (including the subthemes of disabling and debilitating symptoms, limiting ability to work, fear of “crashes” – a sudden drop in blood pressure – forced to depend on others); dismissed and ignored (disregarded as a problem, lacking information, education and reassurance); escalating medication burden; and taking control for improved self‐management (determining thresholds in fluid management, establishing a routine for proactive monitoring).ConclusionBlood pressure symptoms are debilitating for patients on dialysis and exacerbated by a perceived lack of information about how to understand and manage these symptoms. More patient‐centred management of blood pressure, particularly symptom‐causing blood pressure, in patients on dialysis is likely to substantially improve patient satisfaction and outcomes.
Leukemia inhibitory factor promotes gastric cancer cell proliferation, migration, and invasion via the LIFR–Hippo–YAP pathway
Authors: Bian Shi‐Bo , Yang Yun , Liang Wen‐Quan , Zhang Ke‐Cheng , Chen Lin , Zhang Zhong‐Tao 
Published: August 2020

AbstractThe long‐term outcome of gastric cancer (GC) patients remains unsatisfactory despite some recent improvements. Leukemia inhibitory factor (LIF) is a prognostic biomarker for some solid tumors, however its role in GC remains unknown. In this study, we demonstrated that LIF and LIF receptor (LIFR) are overexpressed in GC tissues and established that a correlation exists between them. LIF and LIFR expression are associated with tumor differentiation, lymphovascular invasion, tumor stage, lymph node metastasis, and pTNM stage, indicating that they may be useful prognostic factors. LIF promoted GC cell proliferation, colony formation, invasion, migration, and tumor growth; it also promoted cell cycle progression and inhibited apoptosis; and knocking out the LIFR gene reversed the effects of LIF. LIF inhibited the activity of the Hippo pathway, resulting in reduced phosphorylation of YAP, increased YAP nuclear translocation, and increased cell proliferation. Finally, silencing YAP mRNA expression suppressed cell proliferation. Overall, the results demonstrate that LIF promotes the malignant biological behavior of GC cells through LIFR–Hippo–YAP signaling. LIF may therefore be a useful biomarker for GC.
Persistence or Partisanship: Exploring the Relationship between Presidential Administrations and Criminal Enforcement by the US Environmental Protection Agency, 1983–2019
Authors: Ozymy Joshua , Menard Bryan , Jarrell Melissa L. 
Published: August 2020

AbstractConventional analysis suggests that enforcement actions meted out by the US Environmental Protection Agency vary greatly across Democratic and Republican presidential administrations. Yet research fails to look beyond civil actions to explore how the agency engages in the criminal enforcement of environmental crimes over time or whether and how those outcomes change across partisan administrations. We explore these questions by using content analysis to build a comprehensive dataset of 2,588 criminal enforcement prosecutions, 1983–2019. The results do not suggest that outcomes under Democratic presidents are always substantially more punitive or under Republicans significantly reduced. Outcomes over time better reflect the growing sophistication and institutionalization of the enforcement process, declining budgetary realities, and the agency's organizational commitment to deter serious environmental crimes.
Translation and validation of oral health impact profile‐14 questionnaire into Indian sign language for hearing‐impaired individuals
Authors: Sulekha Shabna G. , Thomas Susan , Narayan Vivek , Gomez Mary Shimi S. , Gopal Raji 
Published: August 2020

AbstractObjectivesTo translate and cross‐culturally adapt the oral health impact profile‐14 (OHIP‐14) questionnaire into Indian sign language (ISL) using a video format and to evaluate its psychometric properties.MethodsThe study was conducted among hearing‐impaired individuals attending the National Institute of Speech and Hearing, Thiruvananthapuram, Kerala. The OHIP‑14 was translated to ISL in a video format. The content validity and face validity were assessed. The final questionnaire was renamed as OHIP‐12 ISL and was administered on 120 hearing‐impaired individuals. Oral health indicators, OHIP‐12 ISL scores, and a single‑item global question (GQ) scores were used for construct validity assessment. Internal consistency and test‐retest reliability were assessed using Cronbach's alpha and intraclass correlation (ICC) coefficient. Discriminant validity was assessed by comparing OHIP‐12 ISL scores with oral health indicators by using Mann‐Whitney U test and Fischer's exact test. Convergent validity was assessed by correlating OHIP‐12 ISL scores with GQ scores and oral health indicators by using Spearman's rank correlation coefficient.ResultsThe OHIP‐12 ISL demonstrated high Cronbach's alpha (α = 0.80). Average ICC coefficient was 0.98 (0.97‐0.99) and demonstrated acceptable construct validity.ConclusionsTranslated and culturally adapted OHIP‐12 ISL is a valid and reliable instrument to measure the OHRQoL among hearing impaired in India.
A cladistic insight into the higher level classification of Baetidae (Insecta: Ephemeroptera)
Authors: Cruz Paulo Vilela , Nieto Carolina , Gattolliat Jean‐Luc , Salles Frederico Falcão , Hamada Neusa 
Published: August 2020

AbstractBaetidae was one of the first families established for mayflies (Ephemeroptera). After more than 200 years of progressive research, Baetidae is now known as the most species‐rich family in the order. Two competing proposals of family division were proposed: Cloeoninae and Baetinae, or Protopatellata and Anteropatellata. Both classifications were established without cladistic support. The purpose of this paper is to investigate the phylogenetic relationships of the family Baetidae using morphological evidence and evaluate these classification schemes. The matrix included 245 morphological characters derived from larval and adult stages across 164 species in 98 genera. The resulting tree recovered Anteropatellata, Protopatellata and Cloeoninae as not monophyletic; Baetinae and Baetovectata were recovered as monophyletic with the same circumscription. Subimaginal and imaginal characters presented the lowest homoplastic values and were the best to understand the higher relationships.
Development and performance characteristics of Platelet Virtual Crossmatch (PLT VXM), a software application for the evaluation and management of platelet transfusion–refractory patients
Authors: Juskewitch Justin E. , Gandhi Manish J. , Kreuter Justin D. , Norgan Andrew P. 
Published: August 2020

AbstractBackgroundPlatelet (PLT) transfusion refractoriness increases bleeding complications, hospital stays, and PLT inventory usage. Immune‐mediated refractoriness can be evaluated for using a physical PLT crossmatch with ABO‐compatible inventory and, if positive, managed with HLA‐compatible PLT inventory and donors. Manual completion of these complex tasks can be time‐consuming and potentially error‐prone. This study was conducted to determine if a Web‐based software application could improve process efficiency and accuracy.Study Design and MethodsWorkflow analysis was performed to identify process, data, and analytic requirements for a software application for three PLT transfusion‐refractoriness associated tasks: (a) physical PLT crossmatch inventory selection, (b) HLA‐compatible inventory selection, and (c) HLA‐compatible donor selection. After software application development, a comparison study was performed over 10 consecutive days, with each task performed manually and with the software application (Platelet Virtual Crossmatch [PLT VXM]) for a different unique immune‐mediated PLT transfusion–refractory recipient. Task completion time, number of incompatible units/donors presented, and number of documentation errors were compared.ResultsPLT VXM is a Web‐based software application developed using R and the Shiny Web application framework. PLT VXM significantly reduced median task completion times by 4.5 (49%), 11.2 (79%), and 59.1 minutes (94%), respectively. PLT VXM did not present any incompatible PLT units or donors for user consideration. PLT VXM also had a lower number of documentation errors than the manual process, and none of these documentation errors were software generated.ConclusionComputer‐aided evaluation and management of immune‐mediated PLT transfusion–refractory recipients can significantly improve workflow and reduce manual errors in this complex process.
The Swedish Scandinavian donations and transfusions database (SCANDAT3‐S) – 50 years of donor and recipient follow‐up
Authors: Zhao Jingcheng , Rostgaard Klaus , Hjalgrim Henrik , Edgren Gustaf 
Published: August 2020

AbstractBackgroundThe two previous versions of the Scandinavian donations and transfusions (SCANDAT) databases, encompassing data on blood donors, blood components, transfusions, and transfused patients linked to national health registers in Sweden and Denmark up until 2012, have been used to study donor health, disease transmission, the role of donor characteristics, and more.Study Design and MethodsHere we describe the creation of the Swedish portion of the third iteration of SCANDAT – SCANDAT3‐S – with follow‐up from 1968 to the end of 2017, resulting in up to 50 years of uninterrupted follow‐up for donors and recipients. The database now also includes non‐transfused non‐donors with a blood typing result, increased temporal resolution for transfusions, and linkages to laboratory and drug prescription data.ResultsAfter data cleaning, the database contained 23 579 863 donation records, 21 383 317 transfusion records, and 8 071 066 unique persons with valid identification. In total, the database offers 28 638 436 person‐years of follow‐up for donors, 13 582 350 person‐years of follow‐up for transfusion recipients, and 65 613 639 person‐years of follow‐up for non‐recipient non‐donors, with possibility for future extension. Additionally, the database includes 167 820 412 dispense records for prescribed drugs and 316,338,442 laboratory test results. Since the latest update in 2012, >99.9% of all donations were traceable to a donor with valid identification, and >97% of all transfusions to a recipient with valid identification.ConclusionWith extended follow‐up and more clinical detail, the Swedish portion of the third and latest iteration of the SCANDAT database should allow for more comprehensive analysis of donation and transfusion‐related research questions.
Peripheral extent of the choroidal circulation by ultra-widefield indocyanine green angiography in healthy eyes
Authors: Verma Aditya , Maram Jyotsna , Alagorie Ahmed Roshdy , van Hemert Jano , Bell Darren J , Singer Michael , Keane Dana , Carnevale Jessica , Nittala Muneeswar , Sadda SriniVas 
Published: August 2020

AimTo analyse the peripheral extent of choroidal circulation using ultra-widefield (UWF) indocyanine green angiography (ICGA) in healthy eyes.MethodsUWF ICGA images of 55 eyes of 36 healthy subjects were captured using the Optos California (Optos, Dunfermline, United Kingdom) in this prospective observational study. Images were analysed to locate the peripheral extent of the visible choroidal circulation, and the boundary was marked in ImageJ (v1.52). Each pixel annotated as the border of the choroidal circulation was projected individually to its anatomically correct location on the three-dimensional model eye, and spherical trigonometry was applied (using the Optos software) to calculate its respective radial distance from the centre of the optic disc in metric units (corrected by stereographic projection) for each quadrant.ResultsThe mean area of the peripheral extent was estimated to be 893.2 mm2 (95% CI: 844.2 to 942.3 mm2). The mean distance (range) of this boundary from optic nerve centre was 18.22 mm (95% CI: 14.0 to 23.14 mm). Multiple regression analysis with age, gender, axial length or ethnicity showed no relationship. There was excellent inter-grader reproducibility, with intraclass correlation coefficients of 0.95 (95% CI: 0.80 to 0.99, p<0.001) for distance and 0.99 (95% CI: 0.988 to 0.999, p<0.001) for area measurements.ConclusionsThe peripheral choroidal boundary may be defined using UWF ICGA. Knowledge of the normal extent and its variability is essential to understand the impact of disease on the choroidal vasculature.
n-Permutability is not join-prime for n ≥ 5
Authors: Gyenizse Gergő , Maróti Miklós , Zádori László 
Published: August 2020

Let [Formula: see text] be the variety generated by an order primal algebra of finite signature associated with a finite bounded poset [Formula: see text] that admits a near-unanimity operation. Let [Formula: see text] be a finite set of linear identities that does not interpret in [Formula: see text]. Let [Formula: see text] be the variety defined by [Formula: see text]. We prove that [Formula: see text] is [Formula: see text]-permutable for some [Formula: see text]. This implies that there is an [Formula: see text] such that [Formula: see text]-permutability is not join-prime in the lattice of interpretability types of varieties. In fact, it follows that [Formula: see text]-permutability where [Formula: see text] runs through the integers greater than 1 is not prime in the lattice of interpretability types of varieties. We strengthen this result by making [Formula: see text] and [Formula: see text] more special. We let [Formula: see text] be the 6-element bounded poset that is not a lattice and [Formula: see text] the variety defined by the set of majority identities for a ternary operational symbol [Formula: see text]. We prove in this case that [Formula: see text] is 5-permutable. This implies that [Formula: see text]-permutability is not join-prime in the lattice of interpretability types of varieties whenever [Formula: see text]. We also provide an example demonstrating that [Formula: see text] is not 4-permutable.
Protestantismo misionero norteamericano en América Latina en el siglo XX
Authors: Fediakova Evguenia 
Published: August 2020

La historia del cristianismo mundial es inseparable de la historia de las misiones. El hecho de ser cristiano contemplaba el deber del creyente de llevar el Evangelio a cada ser humano y a todas las naciones y pueblos del mundo. La expansión de la fe cristiana, la propagación de la cultura occidental en Asia, India, América Latina, eran en gran medida corolario de la labor misionera. En este sentido, la figura del misionero para la formación de la cultura religiosa no occidental redunda de una importancia primordial.
A partir de la presencia misionera, en Latinoamérica es posible observar los conflictos interculturales, las percepciones mutuas de un pueblo acerca del otro, la transformación de un mensaje religioso universal bajo la influencia de las culturas locales y de los cambios de identidad de pueblos latinoamericanos. Sin embargo, el protestantismo misionero se demostró perceptivo a los desafíos y particularidades de las naciones ‘receptoras’. Aun cuando los ‘importadores de Evangelio’ llegaban a terreno con esquemas preconcebidos, la realidad latinoamericana también influyó en ellos. Los problemas económicos, la situación de desigualdad y pobreza que agudizaban los conflictos políticos, tuvieron como consecuencia que la mayor parte de las misiones protestantes conservadoras se vio obligada a cambiar su antigua posición negativa en cuanto al Evangelio social y a aceptar la responsabilidad social de las misiones y del movimiento evangélico en general. El rechazo al mundo resultó insuficiente para contrarrestar la creciente popularidad del marxismo y la Teología de la Liberación, y debieron ser complementados con otras prácticas. Al mismo tiempo, el protestantismo norteamericano tuvo que adaptarse a la singular religiosidad latinoamericana y modificar sus estilos litúrgicos, la participación interna, y las relaciones entre los fieles y los pastores, con mayor emotividad y cercanía. De esta manera, los evangélicos latinoamericanos no eran ‘receptores pasivos’ de las doctrinas extranjeras, sino que protagonistas del proceso de construcción de su propia espiritualidad.
Race Impacts Outcomes of Patients With Firearm Injuries
Authors: Peluso Heather , Cull John D. , Abougergi Marwan S. 
Published: August 2020

Background To study the relationship between race and outcomes of patients with firearm injuries hospitalized in the United States. Methods The 2016 National Inpatient Sample was used. Patients were included if they had a principal diagnosis of firearm injury. Exclusion criteria were age <16 years and elective admissions. The primary outcome was in-hospital mortality. Secondary outcomes were morbidity (traumatic shock, prolonged mechanical ventilation, acute respiratory distress syndrome [ADRS], and ventilator-associated pneumonia [VAP]), and resource utilization (length of stay and total hospitalization charges and costs). Results The sample included 31 335 patients; 52% were Black and 29% were Caucasian. The mean age was 32 years and 88% were male. Black patients had lower odds of mortality (adjusted odds ratio (aOR): 0.41 (95% CI: 0.32-0.53), P < .01). However, compared with Caucasians, Blacks had higher mean total hospitalization charges (adjusted mean difference (aMD) : $14 052 (CI: $1469-$26 635), P = .03) and costs (aMD: $3248 (CI: $654-$5842), P = .01) despite similar mean length of stay (aMD: 0.70 (CI: −0.05-1.45), P = .07). Both racial groups had similar rates of traumatic shock (aOR: 0.91 (0.72-1.15), P = .44), prolonged mechanical ventilation (aOR: 0.82 (0.63-1.09), P = .17), ARDS (aOR: 1.18 (0.45-3.07), P = .74) and VAP (aOR: 1.27 (0.47-3.41), P = .63). Discussion Black patients with firearm injuries had a lower adjusted odds of in-hospital mortality compared with other races. However, despite having a similar hospital length of stay and in-hospital morbidity, -Black patients had higher total hospitalization costs and charges.
Do Head-Mounted Augmented Reality Devices Affect Muscle Activity and Eye Strain of Utility Workers Who Do Procedural Work? Studies of Operators and Manhole Workers
Authors: Marklin Richard W. , Toll Ashley M. , Bauman Eric H. , Simmins John J. , LaDisa John F. , Cooper Robert 
Published: August 2020

Objective The objective was to determine the effect of two head-mounted display (HMD) augmented reality (AR) devices on muscle activity and eye strain of electric utility workers. The AR devices were the Microsoft HoloLens and RealWear HMT-1. Background The HoloLens is an optical see-through device. The HMT-1 has a small display that is mounted to the side of one eye of the user. Method Twelve power plant operators and 13 manhole workers conducted their normal procedural tasks on-site in three conditions: HoloLens, HMT-1, and “No AR” (regular method). Duration of test trials ranged up to 30 s for operators and up to 10 min for manhole workers. Mean and peak values of surface electromyographic (sEMG) signals from eight neck muscles were measured. A small eye camera measured blink rate of the right eye. Results In general, there were no differences in sEMG activity between the AR and “No AR” conditions for both groups of workers. For the manhole workers, the HoloLens blink rate was 8 to 11 blinks per min lower than the HMT-1 in two tasks and 6.5 fewer than “No AR” in one task. Subjective assessment of the two AR devices did not vary in general. Conclusion The decrease in blink rate with the HoloLens may expose utility manhole workers to risk of eye strain or dry-eye syndrome. Application HMD AR devices should be tested thoroughly with respect to risk of eye strain before deployment by manhole workers for long-duration procedural work.