bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell-specific cargo delivery using synthetic bacterial spores
Authors: Kong Minsuk , Updegrove Taylor B. , Constantino Maira Alves , Gallardo Devorah L. , Wu I-Lin , Fitzgerald David J. , Tanner Kandice , Ramamurthi Kumaran S. 
Published: February 2020

ABSTRACTSSHELs are synthetic bacterial spore-like particles wherein the spore’s cell surface is partially reconstituted around 1 µm-diameter silica beads coated with a lipid bilayer. Via a unique cysteine engineered in one of the surface proteins, the surface of SSHELs may be covalently decorated with molecules of interest. Here, we modified SSHELs with an affibody directed against HER2, a cell surface protein overexpressed in some breast and ovarian cancer cells, and loaded them with the chemotherapeutic agent doxorubicin. Drug-loaded SSHELs reduced tumor growth with lower toxicity in a mouse tumor xenograft model compared to free drug by specifically binding to HER2-positive cancer cells. We show that SSHELs bound to target cells are taken up and trafficked to acidic compartments, whereupon the cargo is released in a pH-dependent manner. Finally, we demonstrate that SHELLs can clear small tumor lesions in a complex tumor microenvironment in a zebrafish model of brain metastasis. We propose that SSHELs represent a versatile strategy for targeted drug delivery.
Factors Affecting Response to Recurrent Genomic Selection in Soybeans
Authors: Ramasubramanian Vishnu , Beavis William D 
Published: February 2020

AbstractHerein we report the impacts of applying five selection methods across 40 cycles of recurrent selection and identify interactions among factors that affect genetic responses in sets of simulated families of recombinant inbred lines derived from 21 homozygous soybean lines. Our use of recurrence equation to model response from recurrent selection allowed us to estimate the half-lives, asymptotic limits to recurrent selection for purposes of assessing the rates of response and future genetic potential of populations under selection. The simulated factors include selection methods, training sets, and selection intensity that are under the control of the plant breeder as well as genetic architecture and heritability. A factorial design to examine and analyze the main and interaction effects of these factors showed that both the rates of genetic improvement in the early cycles and limits to genetic improvement in the later cycles are significantly affected by interactions among all factors. Some consistent trends are that genomic selection methods provide greater initial rates of genetic improvement (per cycle) than phenotypic selection, but phenotypic selection provides the greatest long term responses in these closed genotypic systems. Model updating with training sets consisting of data from prior cycles of selection significantly improved prediction accuracy and genetic response with three parametric genomic prediction models. Ridge Regression, if updated with training sets consisting of data from prior cycles, achieved better rates of response than BayesB and Bayes LASSO models. A Support Vector Machine method, with a radial basis kernel, had the worst estimated prediction accuracies and the least long term genetic response. Application of genomic selection in a closed breeding population of a self-pollinated crop such as soybean will need to consider the impact of these factors on trade-offs between short term gains and conserving useful genetic diversity in the context of the goals for the breeding program.
The predictive value of strategic orientation for ESG performance over time
Authors: Chevrollier Nicolas , Zhang Jianhong , van Leeuwen Thijs , Nijhof André 
Published: February 2020

PurposeDespite the scholarly attention for the integration of sustainability within business strategy and processes, little is known about how strategic orientations of companies influence this integration. Drawing on stewardship theory, this paper aims to analyse the influence of strategic orientation of companies on their environmental, social and corporate governance (ESG) performance and the moderating effect of three different political models of economy (Rhine, British and American).Design/methodology/approachThis paper creates a measurement for strategic orientations by using a coding scheme with a five-category evaluation matrix. The main empirical analysis is done by a fixed-effect model with a panel data set covering 179 publicly traded companies over the 2009-2016 period.FindingsThe conclusions of this paper present that – consistent over time – a stronger orientation on stewardship positively associates with higher ESG performance. Additionally, the political model of economy significantly alters the relationship indicating the effect of strategic orientation on ESG performance. The relationship is significantly stronger in the Rhine model and significantly weaker in the British model, when both compared to the American model.Originality/valueThe implications of this paper are vital to understanding corporate strategic orientation and its relationship to actual corporate behaviour and long-term performance. Implementing the elements of focus, motivation, commitment, support and communication linked to a stewardship orientation is fundamental to achieve higher levels of sustainability performance.
Influence of local institutional profile on global value chain participation
Authors: Hong Jin , Zhou Chongyang , Wang Ruicheng 
Published: February 2020

Purpose
The emergence and rapid expansion of global value chains (GVCs) have profoundly changed and reshaped the global trade regime. Although many determinants of GVC participation of enterprises have been discussed extensively in extant literature, the important influence of local institutional profile on GVC participation is often neglected. The purpose of this paper is to investigate the influence of local institutional profile on GVC participation.

Design/methodology/approach
Taking the World Bank Enterprise Survey as the empirical sample, it is used an econometric method (propensity score matching technique) to test the relationship between local institutional profile and GVC participation.

Findings
Local institutional quality is positively related to GVC participation. Moreover, GVC participants display better innovation performance than non-participants. Innovation benefit from GVC participation is contingent upon the abilities of the participants, namely, absorptive capacity and research and development collaboration experience. GVC participants who only either export or import is compared with those who export and import; the findings show that the latter benefits more than the former.

Originality/value
This study offers researchers and practitioners a detailed view of local institutional profile and GVC participation.
Determinants of adoption and continuance intentions toward Internet-only banks
Authors: Lee Jin-Myong , Kim Hyo-Jung 
Published: February 2020

PurposeThe purpose of this study is to investigate the determinants of consumers' intention to adopt or continue to use Internet-only banks based on the benefit–risk framework and network externality theory. It also examines the difference in the determinants between pre- and postadoption stages of innovation.Design/methodology/approachThe proposed research model was tested by using online survey data collected from a South Korean sample, which was divided into two subgroups of 321 nonadopters and 351 existing users.FindingsIn both pre- and postadoption stages, the number of services provided and trust had a significant positive impact on consumers' behavioral intentions, while security risks had a negative impact. Critical mass in the preadoption stage and convenience and economic efficiency in the postadoption stage had positive effects on consumer's adoption intention and continuance intention, respectively.Practical implicationsInternet-only banks must reduce the security risks for consumers and increase their trust. In addition, to facilitate the adoption of nonadopters, focus should be on securing a critical mass; on the other hand, to promote the continued use of existing users, the focus should be on enhancing benefits such as convenience and economic efficiency.Originality/valueThe results of this study confirm the influence of network externalities on consumers' adoption and use of financial technology services and show differences in consumer decision-making according to the innovation diffusion process.
The effect of service improvisation competence on hotel performance
Authors: Secchi Enrico , Roth Aleda , Verma Rohit 
Published: February 2020

PurposeThe development of a service improvisation competence (Serv-IC), operationally defined as “the systemic ability of a service firm’s employees to deviate from established service delivery processes and routines to respond in a timely manner to unforeseen events using available resources” (Secchiet al., 2019, p. 1329), has been proposed as an effective way to accommodate customer variability while increasing the quality of the service experience. However, empirical evidence of its impact on service performance is scant. This paper tests the effect of Serv-IC on performance in the hospitality industry.Design/methodology/approachThis paper develops a conceptual typology of service delivery systems (hereafter service typology is used interchangeably) in the hotel industry based on the experiential content of the service and the amount of standardization of service delivery routines. Then, using a survey of hotel managers, the effect of Serv-IC on hotel performance is estimated within each service group in the typology.FindingsServ-IC is associated with increased occupancy in high-process-standardization and high-experience hotel operations but does not have a significant relationship with the average price per room. The results suggest that managers could invest in Serv-IC to increase loyalty and positive word of mouth but not to increase prices.Originality/valueThis paper provides evidence of the effectiveness of developing a service improvisation competence while also offering boundary conditions to its applicability. The proposed service typology disentangles the design of service processes from their execution, thereby shedding new light on the complex relationships among service design, employee behaviors and business outcomes.
Tourism distribution in small island destinations: the case of Fernando de Noronha, Brazil
Authors: Andrade Amalina , Smith Karen A. 
Published: February 2020

Purpose
This paper investigates tourism distribution channels in a small island destination with capacity constraints and contributes to understanding distribution in an emerging economy. Using the case of Fernando de Noronha in Brazil, the structures and factors underlying channel choice behaviour of tourism suppliers and intermediaries were investigated.

Design/methodology/approach
41 in-depth interviews were conducted with the private sector (tourism suppliers based on Fernando de Noronha and intermediaries, based on the island as well as mainland Brazil) as well as governmental organisations. A stratified purposeful sample was taken to select suppliers and data were examined based on thematic analysis.

Findings
Both direct and indirect distribution channels are used, with limited airline tickets influencing the suppliers' choice of channels in this small island and capacity-constrained destination. Many suppliers focused on relationships with destination-based ground operators. These local intermediaries are important and extremely relevant to small island destinations building an effective business network to connect the destination to geographically distant markets and intermediaries.

Research limitations/implications
Limitations include the absence of air and cruise operators as interviewees.

Originality/value
The paper provides a comprehensive representation of the structures and analysis of tourism distribution channels in fragile small island destinations, specifically, in an emerging country context. This includes emphasising previously unexplored indirect channels of cruise ship operators and supplier's associations.
Innovation management processes and sustainable iterative circles: an applied integrative approach
Authors: Miller Christopher , Thomas Brychan Celfyn , Roeller Michael 
Published: February 2020

PurposeThis study attempts to create new insights into innovation management through the integration of innovation management processes and sustainable, iterative circles. Through the exploration of the use of sustainable, iterative circles in a manufacturing environment, this paper explores their role in facilitating customer-focused innovation practices. Other supporting antecedences for innovative behavior are reviewed, and their combined effect upon delivering cost-effective product developments are assessed.Design/methodology/approachData were collected through semi-structured interviews in manufacturing organizations from the automotive industry. Interviews were conducted with senior functional managers to interpret the application of sustainable, iterative development circles. Analysis of the data was undertaken via thematic analysis based upon pertinent and emergent themes.FindingsSustainable, iterative development circles overcame the inherent path-dependency of traditional linear development approaches, whereas, traditional approaches structure the involvement of key business functions, iterative circles facilitate more flexible approaches to product development that more closely met the requirements of the customer, especially when those requirements are in a state of flux.Practical implicationsThis iterative, customer-centric approach to product development reflects the increasingly dynamic market environments in which manufacturing organizations operate. Using this approach helps to focus the organization’s attention upon customer requirements rather than the challenges of adhering to the rigid dogma of a chosen development methodology.Originality/valueThis study proposes a new approach toward the development of innovations in manufacturing organizations utilizing the sustainable, iterative circles, and therefore, contrasts with the traditional, linear development methodologies that are usually employed.
Applications of MCDM methods in research on corporate sustainability
Authors: Chowdhury Priyabrata , Paul Sanjoy Kumar 
Published: February 2020

PurposeCorporate sustainability (CS) is becoming a popular research topic. In recent years, researchers have conducted a significant number of studies in this area. Although a number of those studies have used a variety of multicriteria decision-making (MCDM) methods, to date there is no systematic literature review of this area of research. This paper fulfills this research gap.Design/methodology/approachThe authors use a systematic literature review and bibliometric analysis approach to analyze the applications of MCDM methods in research on CS.FindingsThe authors have observed that both single and integrated MCDM methods have been used in this domain; however, single MCDM methods are dominant. Further, this review shows that most of the integrated methods use only two MCDM methods and that there has been no comparison of results obtained from different MCDM methods. After reviewing these developments and summarizing the findings, the authors propose directions for future research, including investigating and formulating strategies for specific CS initiatives, integrating three or more MCDM methods, integrating MCDM methods with optimization techniques, analyzing results from a small and medium-sized enterprise (SME) perspective, reconsidering the tenets of existing theories via MCDM methods, and comparing the results of studies of CS in different kinds of economies, as well as the results of using different MCDM methods.Originality/valueTo the best of the authors' knowledge, this is the first study that has conducted a systematic literature review to analyze applications of MCDM methods to different aspects of corporate sustainability, including enablers of and barriers to CS, the evaluation and design of CS initiatives, system or strategy formulation, and performance evaluation, among others.
Effect of the university on the social entrepreneurial intention of students
Authors: Bazan Carlos , Gaultois Hannah , Shaikh Arifusalam , Gillespie Katie , Frederick Sean , Amjad Ali , Yap Simon , Finn Chantel , Rayner James , Belal Nafisa 
Published: February 2020

PurposeThe study aims to test the applicability of a variant of the model proposed by Hockerts (2017) for assessing the social entrepreneurial intention (SEI) of male and female students. It extends the model by incorporating the university's environment and support system (ESS) as an additional more distal construct. The university's ESS, coupled with the experience with social, cultural and environmental issues can affect SEI by influencing the more proximal precursors of empathy towards others, perceived self-efficacy, perceived community support and social, cultural and environmental responsibility.Design/methodology/approachA structured non-disguised questionnaire was administered to students at a Canadian university. A sample of 485 usable responses was analysed by means of second-order structural equation modelling.FindingsThe results provide confirmation that the proposed model is a multi-group invariant and appropriate for analysing the SEI of male and female students. They also show that the university's ESS helps predict SEI indirectly through the complete mediation of the more proximal antecedents.Research limitations/implicationsThe questionnaire is limited to universities with social innovation and entrepreneurship initiatives.Practical implicationsOutcomes of the study can help universities assess the efficacy of their social innovation and entrepreneurship initiatives for instilling a social entrepreneurial mind-set in students. Consequently, universities will be better equipped to raise the perceptions of venture feasibility and desirability, thus increasing students' perceptions of opportunity.Originality/valueThe study advances the social entrepreneurial knowledge of the university's effect on the precursors of SEI.
Lessons from the MH‐17 transboundary disaster investigation
Authors: Kuipers Sanneke , Verolme Ellen , Muller Erwin 
Published: February 2020

AbstractTransboundary crises, incidents, and disasters, such as chemical spills, airplane crashes, and critical infrastructure breakdowns, involving multiple levels and domains of governance pose a particular set of challenges (Ansell et al, 2010; Boin, 2019; Kuipers & Boin, 2015). These challenges also pertain to the investigation and learning phase of a crisis. We study a typical transboundary case: the crash of Malaysia Airlines Flight 17 (MH17), with 298 people on board from a variety of nationalities but the majority from the Netherlands, that crashed in Ukraine in a conflict zone near the Russian border. The MH17 case contains valuable lessons on transboundary disaster investigations. The Dutch Safety Board (DSB) took the lead of the international independent investigation into the causes of the crash. With an international group of stakeholders, the DSB investigated a crash that resulted from a bilateral conflict, requiring the support from Ukraine's powerful neighbour Russia that meanwhile stood accused of withholding evidence and supporting Ukrainian separatists. Retrieving evidence and researching the causality of the crash was no easy task. If countries wish to follow their ambition to learn from accidents in order to “prevent the past repeated,” they may more often need to investigate such transboundary cases. This case study probes into how challenges that are typical to transboundary crises affected the accident investigation into the MH17 disaster. We search for lessons on transboundary accident investigation that transcend the boundaries of this single case. Such lessons may prove invaluable for learning from future accidents.
Current status and progress of concurrent chemoradiotherapy in patients with locally advanced non‐small cell lung cancer prior to the approval of durvalumab
Authors: Fukui Tomoya , Hosotani Shinji , Soda Itaru , Ozawa Takahiro , Kusuhara Seiichiro , Kakegawa Mikiko I. , Kasajima Masashi , Hiyoshi Yasuhiro , Igawa Satoshi , Yokoba Masanori , Mitsufuji Hisashi , Kubota Masaru , Katagiri Masato , Sasaki Jiichiro , Ishiyama Hiromichi , Naoki Katsuhiko 
Published: February 2020

BackgroundThe standard treatment for patients with unresectable locally advanced (LA) non‐small cell lung cancer (NSCLC) is chemoradiotherapy (CRT). Consolidation therapy with durvalumab after CRT demonstrated survival benefits and was approved in Japan in July 2018. The use of immune checkpoint inhibitors (ICIs) is entering routine oncological practice, and here we investigate the feasibility of concurrent CRT for LA‐NSCLC patients based on the PACIFIC criteria.MethodsWe performed a retrospective study to evaluate the feasibility and efficacy of concurrent CRT prior to the approval of durvalumab. We assessed consecutive patients with LA‐NSCLC treated with CRT between January 2012 and June 2018.ResultsWe analyzed a total of 108 consecutive patients who received radical thoracic radiotherapy and concurrent platinum‐based chemotherapy. Of those patients, 105 (97%) completed the planned radiotherapy. Radiation pneumonitis was observed in 93 patients (85%), with a median of 130 days (range: 41–317 days) from the initiation of radiation to the onset of the complication. Among the patients, 74 (69%) were considered eligible for consolidation therapy with durvalumab. The overall response rate was 64%, and the two‐year survival rate was 63%. Patients who received an ICI after relapse were associated with significantly better survival than those who did not receive an ICI (two‐year survival rate: 87% vs. 41%, respectively; P = 0.001).ConclusionsPrior to the approval of durvalumab, the clinical application of ICIs improved the outcome of patients with relapsed NSCLC after CRT for LA‐NSCLC. The management of radiation pneumonitis remains a challenge following the approval of durvalumab.
Systematic review with meta‐analysis: Saccharomyces boulardii for treating acute gastroenteritis in children—a 2020 update
Authors: Szajewska Hania , Kołodziej Maciej , Zalewski Bartłomiej M. 
Published: February 2020

SummaryBackgroundThere is still controversy with regard to the efficacy of individual probiotic strains for the management of acute gastroenteritis.AimTo update evidence on use of Saccharomyces boulardii for treating acute gastroenteritis in children.MethodsThe Cochrane Library, MEDLINE and EMBASE databases were searched from inception to December 2019 for randomised controlled trials (RCTs) that compared use of S boulardii with no S boulardii (defined as placebo or no treatment). The grey literature was searched through Google search. Authors of the original papers and S boulardii manufacturers were contacted for additional data.ResultsTwenty‐nine RCTs (among them, 20 newly identified trials) were included. Only 38% of trials adequately generated their randomisation sequence, only 17% adequately concealed allocation and only one trial adequately blinded participants, study personnel and outcome assessors. However, 83% provided complete outcome data. None of the trials evaluated the effect of S boulardii on stool volume. Compared with placebo or no treatment, S boulardii use reduced the duration of diarrhoea (23 RCTs, n = 3450, mean difference −1.06 day, 95% CI −1.32 to −0.79; high heterogeneity [I2 = 90%]) (very low quality of evidence). S boulardii use was also associated with a reduced duration of hospitalisation (8 RCTs, n = 999, mean difference −0.85 day, 95% CI −1.35 to −0.34; I2 = 91%) (very low quality of evidence). S boulardii reduced the risk of diarrhoea on day 2 to day 7 (low quality of evidence).ConclusionsIn children with acute gastroenteritis, low‐ to very low‐quality evidence suggests that S boulardii confers a benefit for several diarrhoeal outcomes.