bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of intracranial structural lesions diagnosed by computed tomography among children with unprovoked seizure disorder
Authors: Choudhary Priyanka , Mital Amit Kumar , Sinha Sheela 
Published: May 2020

Background: Seizures are the most common pediatric neurological disorder. The objectives were to know the prevalence and types of intracranial structural lesions diagnosed by Computed Tomography in children with unprovoked seizures.Methods: It is hospital based cross-sectional study done in Patna Medical College, India from August 2005- July 2007. All patients aged 6 months to 12 years admitted in pediatrics department with at least 2 episodes of unprovoked seizures were undergone Computed Tomography brain.Results: Out of total 112 patients admitted, 66.1% had abnormal CT scan. Prevalence of abnormal CT scan increased with advancing age and significant, with maximum percentage found in age group 10-12 years (43.2%). Males had more seizures and intracranial lesion than females but this association was statistically non-significant. 65.2% had generalized seizure and 34.8% had partial seizure. Among patients with abnormal CT scan, generalized seizure (70.3%) and partial seizure (29.7%).The commonest probable diagnosis was tuberculoma (47.3%) followed by neurocysticercosis (25.7%) and brain abscess (4%). Other were atrophy, gliosis and hydrocephalus, 2.5% each; arachnoid cyst, extradural hematoma, sturge weber syndrome, tuberous sclerosis, infarct, hemiatrophy, caudate lobe hemorrhage, basal ganglia calcification, corpous callosum agenesis, 1.35% each.Conclusions: Inflammatory granuloma is the leading cause of unprovoked seizure in this part of the country. Every seizure case should undergo a CT scan examination. Preventive measures can be applied for tuberculoma and NCC so as to lower down the burden of seizure disorder.
Clinico-epidemiological and pathological profile of lung cancer: a hospital based observational study in Western part of Rajasthan, India
Authors: Choudhary C. R. , Yogi Suresh Kumar , Purohit Gopal , Borana Hemant , Desai Govind , Sharma Satish Chandra 
Published: May 2020

Background: Lung cancer is the most common cancer causing deaths in men and women world-wide, responsible for over 1 million deaths annually. Although, advances in surgical techniques and combined therapies lung cancer remains a disease with a poor prognosis. Aim of the study was to evaluate the clinico-epidemiological and pathological profile in diagnosed case of lung cancer patients, presenting in the K N Chest hospital.Methods: Initial evaluation after obtaining informed consent, demography, history, clinicoradiological findings of patients and relevant investigations was recorded. Histopathological reports reviewed.Results: Our study included 108 patients with confirmed cases of lung cancer.The mean age of the patients was 57.50 years. The male: female ratio was 5.8:1. Cough was the most common presenting symptom (77.78%) followed by chest pain (62.33%). Clubbing was most commonly associated with squamous cell carcinoma. Most common radiological presentation was consolidation (42.59%) followed by mass lesion (30.55%). Most common histopathological type of lung cancer found in this study was squamous cell carcinoma 47(43.52%) followed by adenocarcinoma 42 (38.89%). Small cell carcinoma was present in 15 (13.89%) and large cell carcinoma was present in 4 (3.70%) study group. The most common pathological cell type in silica dust exposed patient in this study was squamous cell carcinoma followed by adenocarcinoma with occupational history of > 10 years of silica dust exposure in stone mines.Conclusions: Squamous cell carcinoma still remains the commonest histological subtype followed by adenocarcinoma.
Evaluation of the predisposing factors and cause of resistance which are associated with ART 1 failure and shifted to ART 2 regime
Authors: Singh Narendra , Varma R. K. , Giri Richa , Varma Punit , Dwivedi Seema , Kumar Lalit 
Published: May 2020

Background: This study is to evaluate the predisposing factors and cause of resistance which are associated with ART1 failure and shifted to ART 2 regime.Methods: This study was conducted in ART plus centre K.P.S. Post Graduate Institute of Medicine (G.S.V.M. Medical College, Kanpur, India) tertiary care teaching hospital (G.S.V.M. Medical College, Kanpur, India). It will be a clinical (assessment with investigation), continuous, longitudinal, prospective and retrospective, observational, single centre hospital-based study at ART Centre, Kanpur, India. All the subjects who were on 1st line ART regime, attended in our centre were screened for treatment failure of based on clinical, immunological and virological criteria as decided by SACEP. Duration of this study was DEC 2016 TO DEC 2018.This study was taking as regime ART2 as TLATV/R, ZLATV/R, TLLP/R and ZLLP/R.Results: In this study there is PL HIV subjects that are considered for ART2 are mostly living in rural area and more are female having less adherence to ART1. Smoking, alcohol and tobacco chewing were also having less adherence to ART and cause resistance to ART1.Conclusions: In this study subjects were having associated with predisposing factor as Alcohalic 53 (45%), Tobacco Chewing 8 (07%), SMOKING 13 (11%). Alcohalic, Tobacco Chewer and Smoker have significant association of predisposing factor for low adherence to ART1 and resistance to ART1 drugs. There is also concluded that females and rural areas subject are having low adherence and cause ART1 failure.
Influence of exercise on cognitive processing of older woman during dual-task balance: sixteen case reports
Authors: Rodrigues Ana Carolina de Mello Alves , Tinini Rodolpho Cesar dos Reis , Gatica-Rojas Valeska , De Paula Alfredo Mauricio Batista , Guimarães Andre Luis Sena , Monteiro Junior Renato Sobral 
Published: May 2020

BACKGROUND: Older adults require special attention during cognitive-motor tasks since automatic postural control is reduced.
AIM: To analyze the effect of physical exercise on dual-task processing of healthy older women performing standing balance.
METHOD: Sixteen healthy older women were assessed in a quiet standing position with eyes open/closed (single-task, EO, and EC) and with a cognitive task (dual-task, DT) using a Wii Balance Board. All individuals performed training (aerobic, strength, and virtual reality exercises) at moderate effort. Center of pressure (CoP) anteroposterior and mediolateral displacement were analyzed over time pre- and post-training. The Wilcoxon test was used to compare pre- and post-training.
RESULTS: Greater variability in CoP was observed pre- compared to post-training. In the DT, there was a significance decrease in post-training variability compared to pre-training (p<0.01).
CONCLUSION: Physical exercise programs for older adults may contribute to simultaneously improving motor-cognitive performances, associated with improvement in the divided attention.
Understanding the influence of a cognitively demanding task on motor response times and subjective mental fatigue/boredom
Authors: Thompson Chris , Fransen Job , Beavan Adam , Skorski Sabrina , Coutts Aaron , Meyer Tim 
Published: May 2020

BACKGROUND: Several methods are used to induce mental fatigue; predominantly the modified Stroop task, which arguably has little relation to daily lifestyle tasks.
AIM: To investigate the influence of the modified Stroop task on mental fatigue, boredom and motor response times.
METHOD: 15 subjects (24.3±2.3 years) completed a 30-min modified Stroop task (control condition: 30-min reading) and completed PRE, POST and POST 5-min subjective ratings of mental fatigue, mental effort and boredom. Participants' ability to use congruent and inhibit incongruent precues in a choice reaction time task (CRTT) was measured pre- and post- Stroop and control.
RESULTS: Significantly higher subjective ratings of pre-post condition mental fatigue (pre:2.43±1.31 AU, post: 6.42±2.08 AU,p<0.01) and boredom (PRE: 1.65±1.49 AU, POST: 5.03±2.92 AU,p<0.01) were reported following the modified Stroop task condition compared to the control condition mental fatigue (PRE: 1.62±1.17 AU, POST: 2.10±0.92 AU,p>0.05) and boredom (PRE: 1.94±1.52 AU, POST: 3.32 ± 1.66 AU,p>0.05). No significant differences were found between conditions for the extent to which participants’ response times were affected by congruent (p=0.481) or incongruent (p=0.225) precues.
CONCLUSION: Future research must adopt cognitive activities with higher contextual interference for greater ecological validity, and elucidate the impact of rest on recovery from mental fatigue.
Strategi Restructuring Cognitive Dalam Konseling Kelompok CBT Untuk Meningkatkan Kepercayaan Diri Siswa Kelas VIII G di SMP PGRI 1 Buduran Sidoarjo
Authors: Rukmana Oom Linda , Kusbandiami  , Lathifah Maghfirotul 
Published: May 2020

This study aims to determine the effect of the use of cognitive restructuring strategies in group counseling on class VIII G students' confidence in SMP PGRI 1 BUDURAN SIDOARJO. The research design used was a Pre-Experimental study with a One Group Pretest-Postest Design. The population of class VIII G students at SMP PGRI 1 BUDURAN SIDOARJO was 30 students, then 4 students were taken as research samples using purposive sampling techniques. The selection of this sample was chosen based on the results of students' low self-confidence scores through filling in the scale of student confidence measurement. The results of this study was found that there was no significance changed in the use of cognitive restructuring in counseling group on the confidence of students of class VIII G in SMP PGRI 1 BUDURAN SIDOARJO.
Proteomic Study of Hypothalamus in Pigs Exposed to Heat Stress
Authors: Yu Tianyue , Yong Yan-Hong , Li Jun-yu , Fang Biao , Hu Can-ying , Wu Lian-yun , Gooneratne Ravi , Patil Yadnyavalkya , Ju Xianghong , Liu Xiaoxi , Yu Zhichao , Ma Xingbin 
Published: May 2020

Abstract
Background : With evidence of warming climates, it is important to understand the effects of heat stress in farm animals in order to minimize production losses. Studying the changes in the brain proteome induced by heat stress may aid in understanding how heat stress affects brain function. The hypothalamus is a critical region in the brain that controls the pituitary gland, which is responsible for the secretion of several important hormones. In this study, we examined the hypothalamic protein profile of 10 pigs (15 ± 1 kg body weight), with five subjected to heat stress (35 ± 1 °C; relative humidity = 90%) and five acting as controls (28 ± 3°C; RH = 90%). Result: The isobaric tags for relative and absolute quantification (iTRAQ) analysis of the hypothalamus identified 1710 peptides corresponding to 360 proteins, including 295 differentially expressed proteins (DEPs), 148 of which were up-regulated and 147 down-regulated, in heat-stressed animals. The Ingenuity Pathway Analysis (IPA) software predicted 30 canonical pathways, four functional groups, and four regulatory networks of interest. The DEPs were mainly concentrated in the cytoskeleton of the pig hypothalamus during heat stress. Conclusions: In this study, heat stress significantly increased the body temperature and reduced daily gain of body weight in pigs. Furthermore, we identified 295 differentially expressed proteins, 147 of which were down-regulated and 148 up-regulated in hypothalamus of heat stressed pigs. The IPA showed that the DEPs identified in the study are involved in cell death and survival, cellular assembly and organization, and cellular function and maintenance, in relation to neurological disease, metabolic disease, immunological disease, inflammatory disease, and inflammatory response. We hypothesize that a malfunction of the hypothalamus may destroy the host physical and immune function, resulting in decreased growth performance and immunosuppression in heat stressed pigs.
Efficacy and safety of anticoagulant therapy in patients with chronic cirrhosis complicated with portal vein thrombosis: what should we expert from a meta-analysis?
Authors: Liu Yalin , Chen Wanwei , Xu Liangbi , Yang Haoyi , Duan Chenhong , Li Jie 
Published: May 2020

Abstract
Background: Systematic review and meta-analysis were performed to evaluate efficacy and safety of anticoagulant therapy in patients with chronic cirrhosis complicated with portal vein thrombosis (PVT). Methods: The PubMed, The Cochrane Library and Web of Science databases were searched. The odds ratio (OR) and risks ratio(RR) with 95% CI was pooled to calculate the difference in the rate of portal vein recanalization and occurrence of bleeding events between patients who received anticoagulation and those who did not. All meta-analysis were conducted by using a random-effects model. Results: 8 studies with a total of 559 patients published between 2005 and 2019 were finally enrolled in our meta-analysis . The rate of portal vein recanalization was significantly higher with PVT who received anticoagulation and those who did not (OR = 4.689, 95% (95% CI = 3.274–6.716, P=0.000). And the pooled risk ratio of bleeding between the two groups was 0.828 (95% CI = 0.511–1.343, P=0.444). The heterogeneity was not statistically significant among studies, Begg’s funnel plot and Egger’s linear regression test were performed to evaluate publicantion bias. Conclusion: Anticoagulation therapy can significantly improve the recanalization rate of PVT patients with cirrhosis, and the bleeding related events caused by anticoagulation are relatively low, which is worthy of clinical promotion. However, more prospective trials are needed to know how to use anticoagulants.
Genes, pathways and networks responding to drought stress in oil palm roots
Authors: Wang Le , Lee May , Ye baoqing , Yue Gen Hua 
Published: May 2020

Abstract
Background: Palm oil is an important feedstock for biofuel. Palm oil yield is seriously affected by drought stress. However, not much is known about the molecular responses of oil palm to drought stress.Results: We studied the root transcriptomic responses of oil palm seedlings under normal culture and 14-day drought stress using RNA-seq and bioinformatics analysis. We identified 1293 differentially expressed genes (DEGs), involved in several molecular processes, such as cell wall biogenesis and functions, phenylpropanoid biosynthesis and metabolisms, ion transport and homeostasis and cellular ketone metabolic process, as well as small molecule biosynthetic process. We observed that DEGs were significantly enriched into the two categories: hormone regulation and metabolism, as well as ABC transporters. In addition, we identified three protein-protein interaction networks involved in the response to drought stress, including ion transport, reactive nitrogen species metabolic process and nitrate assimilation. Finally, 96 differentially expressed transcription factors were detected to be associated with drought stress response, which were classified into 28 families.Conclusions : The transcriptomic responses of oil palm seedlings to drought stress were systematically analysed, revealing important genes, pathways, networks and transcription factors involved in drought stress responses. These results provide new insights into the mechanisms of drought stress responses in economic crops. The genes and pathways identified in this study provide valuable genomic resources to improve drought tolerance of oil palm by both genetic modification and selective breeding.
Interleukin 1 receptor type 1 gene variants associate with disease susceptibility to IgG4-related periaortitis/periarteritis in IgG4-related disease
Authors: Ashihara Norihiro , Umemura Takeji , Fujinaga Yasunari , Ozawa Makiko , Kuraishi Yasuhiro , Watanabe Takayuki , Hamano Hideaki , Meguro Akira , Kawa Shigeyuki , Ota Masao 
Published: May 2020

Abstract
Background

IgG4-related disease (IgG4-RD) is an immune-mediated disorder characterized by high serum IgG4 concentration and IgG4-bearing plasma cell infiltration in affected organs. IgG4-related periaortitis/periarteritis is a recently identified disease entity in IgG4-RD that affects the cardiovascular system. Since the genetic factors related to disease onset are unclear, we examined the genetic associations with IgG4-related periaortitis/periarteritis susceptibility.
Methods

A recent genome-wide association study identified interleukin 1 receptor type 1 (IL1R1) gene variants in 75 patients with IgG4-RD. Accordingly, 8 single nucleotide polymorphisms (SNPs) in the IL1R1 gene were selected and genotyped in 124 patients with IgG4-RD (43 with IgG4-related periaortitis/periarteritis) and 344 healthy subjects. Serum IL-1β levels were also determined in 102 IgG4-RD patients.
Results

No remarkable SNP associations were detected between IgG4-RD patients and controls. However, the minor allele frequencies of 6 SNPs (rs2287049, rs3917273, rs2160227, rs951192, rs3917318, and rs7582198) were significantly increased in IgG4-related periaortitis/periarteritis patients (corrected P < 0.05). Serum IL-1β levels were significantly lower in patients with IgG4-related periaortitis/periarteritis (P = 0.011) but were not associated with any SNP.
Conclusions

This study indicated that IL1R1 SNPs contributed to IgG4-related periaortitis/periarteritis, but not IgG4-RD, onset. Our findings raise the possibility of certain genetic factors influencing the risk of specific IgG4-RD manifestations.
Morphological and molecular characterization of Ektaphelenchoides pini (Massey, 1966) Baujard, 1984 (Aphelenchoididae; Ektaphelenchinae) from Iran, with morphological and taxonomic observations on some species
Authors: Heydari Fariba , Pedram Majid 
Published: May 2020

Abstract

Ektaphelenchoides pini, the type species of the genus Ektaphelenchoides, was recovered from wood and bark samples of a dead broadleaf forest tree collected from the forests of Golestan province in north of Iran. The recovered population is mainly characterized by massive wide spicules of males with well-developed condylus marked by indentations at the apex and simple distal tip. It was further characterized by 756 to 947 μm long females having a cephalic region slightly separated from the rest body by a shallow depression, 20 to 23 μm stylet with wide lumen lacking conophore and knobs, excretory pore (E pore) at about one metacorpus length behind it, or 92 to 106 μm from anterior end and hemizonid just posterior to it, vagina anteriorly inclined, post uterine sac (PUS) ca 1.2 times vulval body width long, posterior body region elongate conoid, ending to a filiform tip, no functional rectum, a vestigial anus and common males with dorsally convex tail ending to an elongate spike and two pairs of precloacal (P2) and caudal (P3) large papillae at 5 to 6 μm distance anterior to cloacal opening and 30 to 41% of tail, respectively and lacking the single precloacal papilla (P1). In molecular phylogenetic analyses using small and large subunit ribosomal DNA (SSU, LSU rDNA) sequences, the Iranian population of E. pini fell in a clade including species of three genera Ektaphelenchus, Ektaphelenchoides, and Devibursaphelenchus in SSU, and a clade including species of Ektaphelenchus and Ektaphelenchoides in LSU tree, in close association with an isolate identified as E. pini in the latter phylogeny with high (0.99) Bayesian posterior probability (BPP). The comparisons with the type and French populations, as well as phylogenetic affinities of the species using ribosomal data, are discussed. This is the first report of E. pini from Iran, and its first simultaneous morphological and molecular phylogenetic study. New observations on some species of the genus were also presented and discussed.
Potential use of Tifton 85 cultivated in VFCW for animal feed
Authors: Lopes B. C. , Zumalacarregui J. A. G. , Matos M. P. , Matos A. T. , von Sperling M. 
Published: May 2020

Abstract
The objective of this study was to evaluate the nutritional value of Tifton 85 grass (Cynodon dactylon (L) Pers) cultivated in a vertical flow constructed wetland (VFCW) system treating raw sewage. The VFCW operated according to the French system, but with only the first stage and two units in parallel, using a small footprint of 0.6 m2 per inhabitant. Wastewater feeding and resting periods were of seven days each. To evaluate the yield and nutritional value of the Tifton 85 cultivated, samples were collected after 30, 45, 60, 75 and 90 days of growth. They showed yields of 16, 28, 36, 36 and 38 t·ha−1 of dry matter (DM), respectively. The crude protein content decreased sharply during 60 days, however, with values of 29, 23, 15, 15 and 15% DM for the same days, respectively. The results indicate that Tifton 85 could be used for hay production and, to obtain better yield and quality, when used to treat raw wastewater the forage should be cut after between 45 and 60 days of growth.
Influence of ventilation in H2S exposure and emissions from a gravity sewer
Authors: Matos Rita Ventura , Ferreira Filipa , Matos José Saldanha 
Published: May 2020

AbstractThis study was carried out to evaluate the effect of natural ventilation and intermittent pumping events in hydrogen sulfide and methane dynamics, in terms of system operation and risk of gas exposure. Work was conducted in a full scale gravity sewer downstream of pumping stations, in Portugal. Different ventilation rates and locations were assessed, as well as H2S removal rates and potential exposure risk, through the opening of distinct manhole covers. Increased ventilation, resulting from opening of one manhole cover, saw a 38% increase in average pipe air velocity peaks, doubling the estimated rate of air turnovers per day, accompanied by an increase of nearly 20% in H2S average removal rate. Simultaneous opening of two manhole covers induced similar airflow rates through the vent stack, but different rates throughout the pipe. H2S removal rates were also found to differ, according to location of open manholes, but also initial H2S headspace concentration. Under more unfavourable conditions, natural ventilation did not suffice in attaining recommended safety concentrations, regardless of number and location of open manhole covers. H2S concentrations above defined thresholds were verified for all studied setups. Headspace oxygen concentrations below an 18.5% asphyxiation threshold also occasionally occurred, even at manholes immediately downstream of ventilation point.