bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic significance of the preoperative C-reactive protein-to-albumin ratio in patients with colorectal cancer
Authors: Tamagawa Hiroshi , Aoyama Toru , Numata Masakatsu , Maezawa Yukio , Kazama Keisuke , Astumi Yosuke , Hara Kentaro , Kano Kazuki , Yukawa Norio , Saeki Hiroyuki , Godai Tenii , Oshima Takashi , Goda Motohiko , Rino Yasushi , Masuda Munetaka 
Published: November 2020

Background:
The aim of the present study was to determine the utility of the C-reactive protein-to-albumin ratio (CAR) for predicting the overall survival (OS) in locally advanced colorectal cancer (CRC) patients.

Patients and Methods:
This retrospective multicenter study was performed using data from a prospectively maintained database of pathological Stage II or III patients undergoing CRC surgery at the Yokohama City University, Department of Surgery, and its affiliated institutions between April 2000 and March 2016. The risk factors for the OS were identified.

Results:
A CAR of 0.03 was considered to be the optimal cutoff point for classification based on the 1-, 3-, and 5-year survival rates and receiver operating characteristic curve. The OS rates at 3 and 5 years after surgery were 92.4% and 85.7% in the CAR-low group, respectively, and 86.7% and 81.1% in the CAR-high group. A multivariate analysis showed that the CAR was a significant independent risk factor for the OS. When comparing the patients' demographic and clinical characteristics between the CAR ≤0.03 and >0.03 groups, the incidence of patients who received adjuvant chemotherapy and the incidence of postoperative complications were significantly different between the two groups.

Conclusion:
The present study showed that the preoperative CAR was a risk factor for the OS in patients who underwent surgery for CRC. To improve the patients' survival, CAR might be a useful tool for devising treatment strategies.
Detection of Leishmania RNA Virus in Clinical Samples from Cutaneous Leishmaniasis Patients Varies according to the Type of Sample
Authors: Parra-Muñoz Marcela , Aponte Samanda , Ovalle-Bracho Clemencia , Saavedra Carlos H. , Echeverry María C. 
Published: November 2020

ABSTRACTLeishmania RNA virus (LRV) is a double-stranded RNA virus belonging to the Totiviridae family detected as cytoplasmic inclusions in some strains of the human parasite Leishmania spp. Experimental evidence supports the hypothesis that human coinfection with Leishmania spp.–LRV triggers an exacerbated immune response in the host that can be responsible for the observed complicated outcomes in cutaneous leishmaniasis (CL), such as mucosal leishmaniasis (ML) and treatment failure of CL. However, the reported frequencies of LRV associated with complicated outcomes in patient’s series are highly variable, diminishing the relevance on the virus presence in the pathogenesis of the disease. To assess whether or not the inconsistent information about the frequency of LRV associated with CL complicated outcomes could be related to the virus detection approach, the present study evaluated the LRV presence in clinical samples using a diagnostic algorithm according to the type of the sample. In 36 samples with diagnosis of complicated forms of CL (15 of ML and 21 of CL antimony treatment failure) and six samples with non–Leishmania spp. infection, the LRV presence was assessed by RT-PCR, RT-qPCR, and nested RT-PCR. Viral load was estimated in parasite clinical isolates. By combining the methods, LRV1 presence was confirmed in 45% (9/20) of isolates and 37.5% (6/16) of the incisional biopsies. Remarkably, in some cases (4/8), LRV1 was undetectable in the isolates but present in their respective biopsies, and less frequently, the opposite was observed (1/8), suggesting the possibility of loss of parasites harboring LRV1 during the in vitro growth.
Effect of Single and Repeated Administration of Amitriptyline on Experimental Gastric Ulcer
Authors: Hussen Shemsu Umer , Özbakış-Dengız Gunnur , Bas Yilmaz , Kiran Musa 
Published: November 2020

Amitriptyline is an antidepressant drug widely used as analgesic in the management of chronic pain syndromes. It is also attracting the attention of researchers as an alternative agent for peptic ulcer management because studies have shown that most patients with peptic ulcer also suffer from depression. Thus, this study was conducted to investigate gastroprotective effects of single and repeated dose administration of amitriptyline against indomethacin-induced gastric injury in rats. Rats were randomly divided into three groups of eight rats/each. For 14 days, Group I (control) and Group II (single dose) received distilled water; Group III (repeated dose) received 10 mg/kg amitriptyline orally once daily. On day 15, Group I was given distilled water; Group II and III were given 10 mg/kg amitriptyline orally. Thirty minutes later, indomethacin (25 mg/kg) was administrated orally to all the groups. Six hours after indomethacin administration, animals were sacrificed under thiopental sodium anaesthesia, stomachs were rapidly removed, cut along the greater curvature and cleaned. The stomachs were macroscopically evaluated; total area of stomach and visible ulcerated areas were measured using millimeter square paper. Finally, the stomachs were fixed in 10% formalin for histopathologic valuation. Single dose administration of amitriptyline significantly reduced ulcer indexes and gastric erosions as compared to the control group.However, its role against inflammatory reactions such as necrosis, polymorphonuclear leucocyte infiltration, neutrophil and eosinophil reactions were statistically insignificant. On the other hand, repeated dose administration of amitriptilyine produced significant gastroprotective effects as observed from macroscopical and histopathological evaluation results. Moreover, there was also a significant difference in the gastroprotective effects between single and repeated dose of amitriptyline against indomethacin-induced gastric damage. In conclusion, the results of this study evealed that repeated dose administration of amitriptyline showed better gastroprotective effects compared to single dose amitriptyline administration and the control group.
Keywords: amitriptyline, gastroprotective effects, indomethacin, histopathologic evaluation, rats
Sedimentological and geochemical characterization of DF-2 well, Onshore Western Niger Delta: Implications for provenance, tectonic history and paleo depositional conditions
Authors: Amiewalan Florence O. , Balogun Frankie .O. , Ejairu Kingsley 
Published: November 2020

The sedimentology and geochemistry of the major oxides and trace elements of DF-2 well, Onshore, Niger Delta, are presented in this study. The study is aimed at describing the sedimentological characteristics as well as using the major oxides and trace elements to investigate the provenance, tectonic history and palaeo-depositional conditions of the well. Selected samples were investigated with fused bead X-Ray Fluorescence (XRF) spectrometry to determine their major oxides and fused bead laser ablation inductively couple plasma mass spectroscopy (LA-ICP-MS) for their trace elements. Sedimentological analysis from the well shows that the lithology ranged from shaly sand, sandy shale, sandstone and shale. The results show the dominance of silicon oxide (SiO2) contents which ranges from 81.1 to 91.4 wt. % (average of 87.1 wt. %). The low average concentration of Cr<150 ppm and Ni <100 ppm, the ratios of Th/Sc, Th/Co, Th/Cr, Cr/Th, La/Sc, as well as the plots of Th/Co versus La/Sc and TiO2 versus Zr, all infer a felsic source rock. The discrimination plots of ratioK2O/Na2O against SiO2 and Log K2O/Na2O against Log SiO2/Al2O3 indicated passive continental margin. Various chemical classifications of the sediments show that the sandstone facies plotted mainly in quartzarenite, sublitharenite and Fe-rich sand domains. The samples were deposited under oxic environment based on the average values of U/Th (0.26 ppm), Ni/Co (2.79 ppm) and Cu/Zn (1.81ppm) and bivariate plot of Ni/Co versus V/Cr. However, the bivariate plot of Ni/Co versus V/ (V+Ni) specifies oxic to anoxic conditions and V/Vi + Ni ratios indicate oxic, suboxic to euxinicpalaeode positional environments for the sediments. Geochemical characterization illustrates mixed marine and terrigenous source input, deposited mainly in semi humid/humid climate. The positive values attained from ratios of Al2O3/(CaO+MgO+Na2O+K2O) infers mineralogical maturity based on stable mobile oxides content in the studied samples.
Keywords: Felsic Rock, Quartzarenite, Litharenite, Passive Margin, Mobile Oxide, Mature Sediments.
Green corrosion inhibition of mild steel using <I>Prunus Dulcis</I> seeds extract in an acidic medium
Authors: Oshomogho Frederick Okhakumhe , Akhihiero Thelma Ejiro , Edokpayi Osariemen , Ossai Joy Ehimwenma 
Published: November 2020

Synthetic inhibitors use by industries often have adverse effect on the environment. This work therefore investigates the use of plant extract as an inhibition to mild steel corrosion in an acidic environment. Weight loss method was adopted to evaluate inhibition efficiency by plant extract as corrosion inhibitors. Almond seeds (Prunusdulcis) was extracted with the aid of Soxhlet apparatus. The corrosion inhibition experiment was performed by setting up reactors containing mild steel coupon with variable concentrations of plant extract and 200ml of 1.5M HCl solution. The study revealed that the extract was an efficient inhibitor and was most effective as the concentration increased from 0.81% at 0.01g/ml to 69.95% at 0.15g/ml respectively. Adsorption study on mild steel surface showed that the experimental data fitted better into the Temkin isotherm with regression R2 closer to unity. Arrhenius constant and activation energy estimated at temperatures 308K to 328K revealed that activation energy aE increased with increasing inhibitor concentration from 5348.23J/mol at 0.01g/ml to 6151.44J/mol at 0.05g/ml. The outcome of the study revealed that mild steel is susceptible to corrosionwhich is capable of destroying the material and increasing inhibitor concentration and temperature has significant influence on the corrosion.
Keywords: Mild steel, Corrosion, Inhibitor, Plant Extract, Adsorption
Diversity in proximate analysis of tubers of some African yam bean (<i>Sphenostylis stenocarpa</i>) (Hochst Ex. A. Rich.) Harms (Fabaceae) accessions
Authors: Konyeme T.E. , Nyananyo B.L. , Tanee F.B.G. 
Published: November 2020

This study was carried out to determine the proximate and mineral composition of fresh tubers of 17 African Yam Bean (AYB) accessions. Standard analytical procedures were adopted in the determination of bioactive compounds in the tubers of the different accessions. Data were subjected to descriptive statistics, principal component and clustering analysis. Ash content ranged between 4.59-9.99%, Carbohydrate (46.59-66.52%), Crude fibre (6.93-12.13), Fat (1.06-4.04%), Moisture content ranged between 11.36-21.91% and Protein (4.91-14.50%). The range of mineral content evaluated were: Calcium (1.53-5.82), Copper (10.59-44.93), Iron (63.52-240.48), Magnesium (0.59-2.26), Manganese (42.25-160.01), Nitrogen (0.75-2.23%), Potassium (1.34-5.08), Sodium (0.05-0.22) and Zinc (28.24-106.93. The proximate variables in the tubers significantly (P<0.05) distinguished the 17 AYB accessions. Three distinct clusters were visible. The seven accessions in cluster I had the highest protein, carbohydrate and moisture content. Cluster II had the least mineral content. Accessions with the highest fat and mineral content were grouped in cluster III. Food, nutritional and medicinal values inherent in AYB tubers is high and promising, its utilization in human and livestock feeds is greatly encourage.
Keywords: Accessions, African yam bean, diversity, proximate analysis, tubers
Assessment of physicochemical characteristics of lower River Niger at Kpata, Adankolo and Gadumo Stations in Kogi State, Nigeria
Authors: Ogbe K.U. , Adejoh O.S. , Dasuma E 
Published: November 2020

The present work was conducted to study the physicochemical parameters of lower River Niger at Lokoja and Ajaokuta local government area of Kogi state, with the aims to determine the physical and chemical situation of the River at this point in time, compare the physical and chemical situation of the river with earlier work done on River Niger and other relevant water bodies by relevant authors also to determine its suitability for fish growth and survival at this point in time. Water samples were collected for four month (January to April) at three sampling site (two site from Lokoja and one from Ajaokuta local government area) and analysed for various physicochemical parameter. The mean temperature values ranged from 23.55 - 28.350C at Kpata station, 24.65- 29.750C at Adankolo station and 23.90-28.900C at Gadumo station. The mean pH values ranged from 6.69-8.15 at Kpata station, 6.60-8.30 at Adankolo station and 6.10-8.20 at Gadumo station. The mean electrical conductivity values ranged from 68.50-135.50µS/cm at Kpata station, 68.00-122.50 µS/cm at Adankolo station and 68.00-122.50 µS/cm at Gadumo station. The mean dissolved oxygen (DO) values ranged from 6.10-9.30 mg/l at Kpata station, 5.65-7.78 mg/l at Adankolo station and 6.10-9.30 mg/l at Gadumo station. The mean transparency values ranged from 0.31-0.60m at Kpata station, 0.31-0.60m at Adankolo station and 0.30-0.44m at Gadumo station. The mean biochemical oxygen demand (BOD) values ranged from 2.10-2.95 mg/l at Kpata station, 2.05-3.25 mg/l at Adankolo station and 2.10-4.00 mg/l at Gadumo station. The mean nitrate values ranged from 0.02-0.05 mg/l at Kpata station, 0.02-0.03 mg/l at Adankolo station and 0.02-0.04 mg/l at Gadumo station. The mean phosphate values ranged from 0.48-0.61 mg/l at Kpata station, 0.51-0.65 mg/l at Adankolo station and 0.49-0.64 mg/l at Gadumo station. The study indicated that the mean value of the studied parameters which include pH, temperature, dissolved oxygen, Electrical conductivity, biochemical oxygen demand, nitrate, transparency and phosphate of the River compares slightly favourably with the work of other researchers and within the range that support fish growth and survival. This indicates that the river is in a healthy state and is favourable for fish growth and survival.
Keywords: physiochemical parameter, water, river Niger, fish growth
Seasonal variation of the hydro-environmental factors and phytoplankton community around waters in Tincan Island, Lagos State, Nigeria
Authors: Okere M.C. , Davies I.C. , Okonkwo S.E. 
Published: November 2020

The phytoplankton diversity, pigment, abundance and distribution in relation to physico-chemical parameters were studied from four stations for a period of five months (May – September 2018) and were analysed using standard procedures. Rainfall was highest (329.5 mm) in September and lowest (142.7 mm) in July. The total suspended solid (TSS) had a mean value of 63.10±12.81 mg/L and the total dissolved solids (TDS) had the highest value of 15189 mg/L in May which was not significantly different around the sampling points {P > 0.05}. The pH and nitrate level recorded had a mean value of 7.25±0.33 and 3.11±1.33 mg/L respectively. Microscopic identification revealed a total of 129 species belonging to 62 genera, 22 families and five divisions in the following order of specie abundance: Bacillariophyceae (65 taxa) > Cyanophyceae (27 taxa) > Chlorophyta (20 taxa) > Dinophyceae (10 taxa) > Euglenophyceae (7 taxa). The high dominance of Microcystis aeruginosa observed was indicative of organic pollution. The range of community structure indices were as follows: Margalef Index (0.1406 – 5.295) and Shannon – Weiner Index (0.02644 - 0.4979). The relatively high nutrient status favours the high abundance of phytoplankton which is understood to be deleterious to the ecosystem. Municipal wastes must be treated or recycled before discharge and a continuous environmental surveillance is required to maintain the biological integrity of this area.
Keywords: Phytoplankton, Physicochemical Parameters, Nutrient Status and Tincan Island
Interpretation of the concept of joint property of spouses in international private legal relations
Authors: Руденко А.В. , Бугара Е.И. 
Published: November 2020

В настоящей статье рассматриваются вопросы законного и доктринального толкования совместной собственности супругов в Российской Федерации. Проанализирован подход зарубежных стран к составу такого имущества и режимам его регулирования. Семейные отношения относятся к частноправовой сфере, что предполагает минимальное вмешательство государства к вопросам их регулирования. Имущественное положение супругов разниться, в том числе, и в зависимости от правовой семьи, которая характерна для отдельно рассматриваемого государства.
This article addresses the issues of legal and doctrinal interpretation of joint property of spouses in the Russian Federation. The approach of foreign countries to the composition of such property and the regimes of its regulation is analyzed. Family relations belong to the private law sphere, which implies minimal state intervention in their regulation. The property statuses of the spouses vary, including, and depending on the legal family, which is characteristic of a separately considered state.
ĐÁNH GIÁ KẾT QUẢ PHẪU THUẬT SỬA TOÀN BỘ BỆNH CHUYỂN VỊ ĐẠI ĐỘNG MẠCH (TGA) TẠI BỆNH VIÊN TIM HÀ NỘI
Authors: Hien Nguyen Sinh , Lan Vu Thi 
Published: November 2020

Từ 10/2014- 10/2017, 25 bệnh nhân TGA đã phẫu thuật sửa toàn bộ tại Bệnh viện Tim Hà Nội. Tuổi nhập viện trung bình 25,8 ± 28,5 ngày tuổi .Cân nặng trung bình: 3,83 ± 1,09 kg. Tỷ lệ sống ra viện là 92% (23 trường hợp); tử vong là 8% (2 trường hợp). Kết quả phẫu thuật sớm sửa toàn bộ chuyển vị đại động mạch là khả quan với tỷ lệ thành công là 92%.
ĐƯỜNG CONG HUẤN LUYỆN TRONG PHẪU THUẬT VAN HAI LÁ ÍT XÂM LẤN QUA ĐƯỜNG MỞ NGỰC NHỎ BÊN PHẢI
Authors: Anh Vo Tuan , Dinh Nguyen Hoang 
Published: November 2020

Đây là nghiên cứu theo dõi dọc tiến cứu kết hợp hồi cứu các bệnh nhân được phẫu thuật van hai lá ít xâm lấn qua đường mở ngực nhỏ bên phải tại bệnh viện Đại học Y Dược TP.Hồ Chí Minh từ tháng 8 năm 2014 đến tháng 1 năm 2019. Thời gian chạy máy tim phổi nhân tạo, kẹp động mạch chủ, thời gian thở máy và thời gian nằm hồi sức được đánh giá xu hướng theo năm. Số lượng ca phẫu thuật cần thiết để vượt qua đường cong huấn luyện được đánh giá bằng biểu đồ tổng tích lũy của thất bại kĩ thuật (Cumulative Sum – CUSUM). Trong thời gian nghiên cứu, có 204 trường hợp phẫu thuật van hai lá ít xâm lấn qua đường mở ngực nhỏ bên phải. Tuổi trung bình của bệnh nhân là 48.5  24.9, nhóm tuổi 51 – 60 tuổi chiếm tỉ lệ cao nhất. Lý do nhập viện thường gặp nhất là khó thở khi gắng sức (94,1%). Tỉ lệ biến chứng kĩ thuật là 5,4%. Thời gian tuần hoàn ngoài cơ thể, thời gian kẹp động mạch chủ, thời gian thở máy và thời gian nằm hồi sức giảm dần theo thời gian và theo số lượng ca mổ tích lũy. Số lượng bệnh nhân cần để vượt qua được đường cong huấn luyện là 75 đến 100 trường hợp.
20 NĂM KINH NGHIỆM VỚI VAN SORIN BICARBON TRÊN 2661 BỆNH NHÂN
Authors: Phan Nguyễn Văn 
Published: November 2020

Mục tiêu nghiên cứu: nhằm nghiên cứu kết quả theo dõi dài hạn của van nhân tạo cơ học Sorin Bicarbon hai lá, động mạch chủ hoăc cả hai van.Phương pháp: từ 1993 đến 2012, 2661 bệnh nhân được thay van tại Viện Tim thành phố Hồ Chí Minh bao gồm: van động mạch chủ 1469 (55.2%), van hai lá 396 (14.9%), khoảng 30% bệnh nhân đươc thay cả hai van. Bệnh nguyên của van tim đa số là thấp tim (n=2386, 90%), tương ứng với tuổi trung bình của nhóm dân số là 38 ±3.6 tuổi (8-80 tuổi). thời gian theo dõi trung bình 14 ± 6.2 năm và 2310 bệnh nhân đượctheo dõi (87%).
Kết quả: tử vong phẫu thuật là 2.3%. tử vong chủ yếu do suy tim (1.9%) xảy ra ở 8 trường hợp thay van ĐMC, 26 trường hợp thay van hai lá và 28 trường hợp thay cả hai van. Trước mổ, đa số các bệnh nhân đều có NYHA I (44.1% nhóm bệnh nhân thay van ĐMC), NYHA II (40.7% ở nhóm thay van ĐMC, 35.1% ở nhóm thay van hai lá và 46.8% ở nhóm thay cả hai van) và NYHA III (40.1% ở nhóm thay van hai lá, 41.5% ở nhóm thay van ĐMC). Tỉ lệ sống còn sau 18 năm là 96 ± 2.6 % và tử vong muộn là 0.7% (18/2661). Tỉ lệ không bị viêm NTMNT, không bị huyết khối- huyết tắc và không bị xuất huyết sau 18 năm tương ứng là 98.1 ± 0.6%; 96.2 ± 1.4% và 98.4 ± 0.8%. không có ghi nhận những tổn thương cấu trúc của van. Tỉ lệ không bị mổ lại sau 18 năm là 96.498.1 ± 0.6%; 96.2 ± 1.4%, and 98.4 ± 0.8%2.7%, với 24 trường hợp bị huyết khối (2 trường hợp ở nhóm thay van ĐMC, 18 trường hợp ở nhóm thay van hai lá và 4 trường hợp ở nhóm thay cả hai van), 14 trường hợp bị Pannus (4 trường hợp ở nhóm thay van ĐMC,8 trường hợp ở nhóm thay van hai lá và 2 trường hợp ở nhóm thay cả hai van), 9 trường hợp bị hở cạnh van (3 trường hợp ở nhóm thay van ĐMC, 6 trường hợp ở nhóm thay van hai lá ) và VNTMNT (2 trường hợp ở nhóm thay van ĐMC, 4 trường hợp ở nhóm thay van hai lá và 3 trường hợp ở nhóm thay cả hai van).
Kết luận: nghiên cứu này cho thấy tỉ lệ tử vong và biến chứng thấp đối với các bệnh nhân thay van nhân tạo cơ học SBC sau hơn 20 năm, xác nhận tính tin cậy và độ bền của loại van nhân tạo cơ học này.
The synergistic impact of ENSO and IOD on Indian summer monsoon rainfall in observations and climate simulations – an information theory perspective
Authors: Pothapakula Praveen Kumar , Primo Cristina , Sørland Silje , Ahrens Bodo 
Published: November 2020

Abstract. The El Niño–Southern Oscillation (ENSO) and Indian Ocean Dipole (IOD) are two well-known temporal oscillations in sea surface temperature (SST), which are both thought to influence the interannual variability of Indian summer monsoon rainfall (ISMR). Until now, there has been no measure to assess the simultaneous information exchange (IE) from both ENSO and IOD to ISMR. This study explores the information exchange from two source variables (ENSO and IOD) to one target (ISMR). First, in order to illustrate the concepts and quantification of two-source IE to a target, we use idealized test cases consisting of linear and nonlinear dynamical systems. Our results show that these systems exhibit net synergy (i.e., the combined influence of two sources on a target is greater than the sum of their individual contributions), even with uncorrelated sources in both the linear and nonlinear systems. We test IE quantification with various estimators (linear, kernel, and Kraskov estimators) for robustness. Next, the two-source IE from ENSO and IOD to ISMR is investigated in observations, reanalysis, three global climate model (GCM) simulations, and three nested higher-resolution simulations using a regional climate model (RCM). This (1) quantifies IE from ENSO and IOD to ISMR in the natural system and (2) applies IE in the evaluation of the GCM and RCM simulations. The results show that both ENSO and IOD contribute to ISMR interannual variability. Interestingly, significant net synergy is noted in the central parts of the Indian subcontinent, which is India's monsoon core region. This indicates that both ENSO and IOD are synergistic predictors in the monsoon core region. But, they share significant net redundant information in the southern part of the Indian subcontinent. The IE patterns in the GCM simulations differ substantially from the patterns derived from observations and reanalyses. Only one nested RCM simulation IE pattern adds value to the corresponding GCM simulation pattern. Only in this case does the GCM simulation show realistic SST patterns and moisture transport during the various ENSO and IOD phases. This confirms, once again, the importance of the choice of GCM in driving a higher-resolution RCM. This study shows that two-source IE is a useful metric that helps in better understanding the climate system and in process-oriented climate model evaluation.