bluuebunny/crossref_metadata_2025_split huggingface dataset:
P6167Low leptin plasma levels are associated with progression of coronary atherosclerosis in patients with stable coronary artery disease from the SMARTool Study
Authors: Caselli C , Rocchiccioli S , Rosendael A , Buechel R , Teresinska A , Pizzi M N , Smith J M , Poddighe R , Campolo J , Vozzi F , Knuuti J , Pelosi G , Parodi O , Scholte A , Neglia D 
Published: October 2019

Abstract

Background
Leptin is an adipokine involved in energy homeostasis and has been related with established vascular risk factors. However, studies on the association of leptin plasma levels with coronary artery disease (CAD) have yielded conflicting results.

Purpose
Aim of the present study was to evaluate the association between leptin plasma levels and presence, severity and progression of coronary atherosclerosis in patients with suspected stable CAD.

Methods
In a cohort of 257 patients with symptoms of stable CAD enrolled in the SMARTool study, coronary computed tomography angiography (CTA), plasma leptin levels and clinical and bio-humoral CAD risk profile (including glucose, lipid and inflammation variables) were obtained at enrolment and after 6±1yrs of follow-up. Sixty-four patients were revascularized and the remaining 193 represent the population for the present study. CTA findings were categorised as no-minimal CAD (<30% stenosis), non-obstructive CAD (30%-50% stenosis) and obstructive CAD (≥50% stenosis in at least one major coronary vessel). A CTA risk score (based on plaque extent, severity, composition, and location) was calculated at baseline and at follow-up to assess coronary atherosclerotic burden and its progression (Δ CTA score≥5).

Results
CTA findings showed obstructive CAD in 11% of patients at baseline and in 15% at follow-up (p<0.0001). CTA risk score, was 8.03±7.80 at baseline and increased to 10.33±8.17 at follow-up (p<0.0001) with CAD progression in 20% of patients. Leptin plasma levels were inversely related with CTA findings both at baseline and follow-up (Figure). In a Cox model, baseline plasma leptin was an independent predictor of CAD progression, after adjustment for clinical risk factors, biomarkers, and treatment (HR 0.572, 95% CI 0.393–0.834, P=0.0037).
Figure 1

Conclusion
Plasma leptin is inversely associated with coronary atherosclerotic burden and disease progression in patients with stable CAD. This association is independent of known factors affecting leptin levels. These results could prompt further investigations on the pathophysiological mechanisms of this association.

Acknowledgement/Funding
EU H2020 research and innovation program under grant agreement No 689068
P6175Prediction of coronary revascularization by coronary computed tomography angiography derived fractional flow reserve - different algorithms for interpretation
Authors: Madsen K T , Veien K T , Noergaard B L , Larsen P , Deibjerg L , Husain M , Junker A , Kusk M W , Thomsen K K , Rohold A , Jensen L O , Sand N P 
Published: October 2019

Abstract

Introduction
Coronary CT angiography (CTA) derived fractional flow reserve (FFRct) is increasingly used for guiding referral to invasive procedures in patients with stable chest pain. However, optimal interpretation of FFRct-analysis in terms of location and threshold of applied FFRct-values is unclear.

Purpose
To evaluate the clinical performance of various vessel-specific physiological FFRct derived measures of ischemia for prediction of standard of care guided coronary revascularization in patients with stable chest pain and coronary artery disease as determined by coronary CTA.

Methods
Retrospective study in patients with stable chest pain referred for coronary angiography based on coronary CTA. Standard acquired coronary CTA data sets were transmitted for core-laboratory analysis at HeartFlow. Any FFRct value in the major coronary arteries ≥1.8 mm in diameter, including side branches, were registered. Lesions were categorized as positive for ischemia using 6 different algorithms: Lowest in vessel FFRct-value (1) ≤0.75 or (2) ≤0.80; 2 cm distal-to-lesion FFRct-value (3) ≤0.75 or (4) ≤0.80; ΔFFRct (5) ≥0.06 or a combination of 2 and 5. The personnel responsible for downstream patient management had no information regarding FFRct test results.

Results
A total of 172 patients were included. Revascularization was performed in 62 (35%) patients. The diagnostic performance of different FFRct algorithms for predicting standard of care guided coronary revascularization is shown in the Table.
Revascularization Predictions by FFRct N=172 Diagnostic performance FFRCT false negative FFRCT false positive Values given as (%) No. of revasc vessels No. of abnormal vessels FFRCT Algorithm Sens Spec PPV NPV Acc 1 2 3 1 2 3 Distal FFRCT ≤0.75 77 68 58 84 72 12 2 0 29 5 1 Distal FFRCT ≤0.80 92 43 48 90 61 5 0 0 40 20 3 Lesion-specific FFRCT ≤0.75 68 86 74 83 80 17 3 0 12 3 0 Lesion-specific FFRCT ≤0.80 82 78 68 89 80 10 2 0 21 3 1 ΔFFRCT ≥0.06 98 36 47 98 59 1 0 0 51 19 0 Combinationa 92 54 53 92 67 5 0 0 39 12 0 aDistal FFRCT ≤0.80 and ΔFFRCT ≥0.06. Sens = sensitivity; Spec = specificity; PPV = positive predictive value; NPV = negative predictive value; Acc = accuracy; FFRCT = fractional flow reserve derived from coronary CTA; ΔFFRCT = difference between FFRCT-value immediately proximal and distal to lesion; Revasc = revascularized.

Conclusion
The diagnostic performance of FFRct in terms of predicting standard of care guided coronary revascularization is dependent on the applied algorithm for interpretation of the FFRct-analysis.
P6176Added value of computed tomography fractional flow reserve (FFRCT) in the diagnosis of coronary artery disease (CAD)
Authors: Peper J , Schaap J , Kelder J C , Grobbee D E , Swaans M J 
Published: October 2019

Abstract

Purpose
Multiple non-invasive tests are performed as part of the standard protocol to diagnose CAD, but all are limited to either anatomical or functional assessments. FFRCT is a new non-invasive test that combines anatomical and functional characteristics based on the principles of invasive FFR. This study aims to evaluate the added value of FFRCT beyond the currently used tests.

Methods
Patients having the clinical suspicion of angina pectoris between 2010 and 2011 were included in this cross-sectional study. All underwent exercise stress electrocardiography (X-ECG), SPECT, CT coronary angiography (CCTA) and FFRCT as part of the Horoscope study. Invasive coronary angiography (ICA) and FFR were used as reference standard. Missing values were multiple imputed and five combined models mimicking the clinical workflow were fitted. The area under the receiver operating characteristic (AUROC) curve and Akaike Information Criteria (AIC) were used for comparison.

Results
89 (44%) of the 202 patients included in the analysis had a FFR of ≤0.80, while positive tests were found for X-ECG, SPECT, CCTA and FFRCT in 41%, 47%, 53% and 50% of the cases. The model including pre-test-likelihood and X-ECG had an AUROC of 0.78 (AIC: 236), which significantly increases to 0.89 by adding SPECT (AIC: 170), to 0.87 by adding CCTA (AIC: 191), to 0.92 when adding FFRCT (AIC: 155) and to 0.94 when adding CCTA and SPECT (AIC: 1 40).
ROC-curves for all diagnostic models Model 1 Model 2 Model 3 Model 4 Model 5 Basic model + SPECT + CCTA + CCTA + FFRCT +SPECT + CCTA AIC 236.0 169.8 190.8 154.5 140.1 AUC 0.78 0.89 0.87 0.92 0.94 ROC-curves for all diagnostic models and its AIC and AUC. FFRCT has an improved AUC compared to the basic model and the models including SPECT or CCTA alone, while its AIC is decreased. The model including both SPECT and CCTA has the highest AUC and the lowest AIC and seems therefore the preferable strategy.
ROC curve

Conclusion
This study shows adding FFRCT leads to an increased AUROC and a decreased AIC compared to the basic model. It therefore improves the diagnostic work-up beyond SPECT or CCTA alone in the diagnosis of CAD.
P6200Effect of LPA gene on CAD risk among diabetic patients
Authors: Borges S , Palma Dos Reis R , Pereira A , Mendonca F , Sousa J , Monteiro J , Neto M , Sousa A C , Rodrigues M , Henriques E , Ornelas I , Freitas A I , Drumond A , Mendonca M I 
Published: October 2019

Abstract

Introduction
Previous research reported that LPA gene is a strong and independent predictor of CAD in non-diabetic patients but not in patients with type 2 diabetes. These results suggest that LPA gene might contribute less to CAD risk in patients with T2DM than in general population.

Objective
Investigate, in our population, the association between LPA gene CT variant and CAD risk among diabetic patients.

Methods
3050 individuals (1619 coronary patients and 1431 controls) were genotyped for LPA rs3798220 TT/CT. Pearson's chi-squared test was applied to evaluate the association between LPA variants and CAD, firstly, in the general population and, secondly, in the group of patients with T2DM (n=735). Multivariate logistic regression was performed with LPA CT variant and 6 traditional risk factors (TRF) (smoking, dyslipidemia, diabetes, hypertension, family history of CAD and physical inactivity) in both general and diabetic population.

Results
In total population, LPA CT variant was found to be strongly and significantly associated with CAD with an OR of 2.32 (95% CI: 1.56–3.45; p<0.0001). However, this association was less pronounced in the diabetic population with a CAD risk of 1.38 (95% CI: 0.56–3.43) without statistical significance (p=0.485). In the presence of 6 major TRF, multivariate analysis showed that LPA CT remained a strong and independent predictor of CAD risk (OR= 2.34; 95% CI: 1.52–3.62; p<0.0001). In diabetic population, LPA was no longer an independent predictor for CAD by multivariate analysis.

Conclusions
Our results show that the effect of LPA gene on CAD risk among diabetic patients might be different from that in the general population. Diabetes status is such a strong risk factor that may attenuate the genetic effects of LPA on CAD risk. This may indicate a complex role of Lp (a) and diabetes interaction in cardiometabolic diseases.
P6212The NAILED ACS trial - telephone-based long-term follow-up reduces risk factors after 36 months
Authors: Henriksson R , Huber D , Mooe T 
Published: October 2019

Abstract

Background
Cardiovascular secondary preventive strategies need improvement. The proportion of patients reaching guideline recommended treatment targets are low.

Purpose
We investigated if nurse-led, telephone-based follow-up including medical titration was superior to usual care in controlling blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) levels 36 months after an acute coronary syndrome (ACS).

Methods
All patients admitted with ACS at the local county hospital between 1st January 2010 and 31st December 2014 were screened for inclusion based on their ability to participate in a telephone-based follow-up. Participants were randomized into two parallel groups, an intervention group and a control group receiving usual care. BP and LDL-C were measured at one month, 12, 24 and 36 months. The intervention group received counseling and medical titration to attain treatment targets of BP (<140/<90 mmHG) and LDL-C (<2.5/<1.8 mmol/L). The primary outcome was LDL-C at 36 months.

Results
Out of 962 randomized patients, 797 were available for analysis after 36 months. In the intervention group, mean systolic blood pressure (SBP) was 4.1 mmHg lower (95% CI 1.7 - 6.4, p=0.001), diastolic blood pressure (DBP) was 2.8 mmHg lower (95% CI 1.4- 4.4, p<0.001) and mean LDL-C was 0.26 mmol/L lower (95% CI 0.12 - 0.4, p<0.001) when compared to the control group. The proportion of patients reaching treatment target goals was also significantly higher in the intervention group.

Conclusions
After 36 months of follow-up the nurse-led, telephone-based intervention led to significantly lower systolic blood pressure, diastolic blood pressure and LDL-C levels when compared to the control group. The intervention group also had a larger proportion of patients reaching target values.

Acknowledgement/Funding
The study received funding from the research and development unit, Region Jämtland Härjedalen.
P6213The influence of working-age on attendance to cardiac rehabilitation: a gender comparison
Authors: Astley C , Chew D P , Keech W , Nicholls S , Beltrame J , Horsfall M , Tavella R , Tirimacco R , Clark R 
Published: October 2019

Abstract

Introduction
Despite guidelines recommending referral to cardiac rehabilitation (CR), attendance remains poor. Literature cites a complexity of clinical, psychological and social factors as barriers to CR attendance and, females may attend less than males. Social factors including work commitments, may influence attendance, with many Australian CR programs offered during office hours, making access difficult. The Australian retirement age for females and males differs; (females >60 years and males >65 years). We hypothesised that working-age may influence attendance to CR.

Purpose
In a CR-referred population this study sought to compare working-age of males and females and the association with CR attendance.

Methods
Data from 24 country and metropolitan CR services between 2013 and 2015 were linked to 49,909 CR-eligible patients defined as, discharged alive with a primary cardiac-related diagnosis and/or interventional procedure, identified through public hospital administrative data (Figure). Only CR-referred patients were included, with males and females categorised by three age groups: <60, 60–65 and >65 years, comparing attendance in univariate analysis. Adjustment for clinical and psychological (International Classification of Disease-10 Australian Modification mental health diagnostic-related group diagnoses) factors were conducted using multi-logistic regression.

Results
Between 2013–2015, 15,089 patients were referred to CR with 4,819 <60 years, 1,943 between 60–65 years and 8,327 >65 years. Of referrals a total of 4,286 (28.4%) attended CR, 1134 (35%) of whom were female. Univariate analysis observed total attendance by age group ranged between 26–32%, with females less likely to attend than males (<60 years; 25.3% v 32.2%, p<0.001, 60–65 years; 29.5% v 33.2%, p=0.130 and >65 years; 23.2% v 23.6%, p<0.001). Multivariate analysis observed more attendance in the 60–65 years group compared to <60 years (odds ratio (OR): 1.15 [95% confidence interval [CI]: 1.00–1.32], p=0.036) with females less likely to attend than males (OR: 0.81, [95% CI; 0.70–0.95], p=0.009). No interaction between the working age classification and gender were observed.

Conclusion
In an Australian cohort, working-age observed no influence on cardiac rehabilitation program attendance, with the period of female retirement age observing a 19% reduction in attendance. Further research on the complexity of factors that may be barriers to attendance is essential to evaluate how to improve cardiac rehabilitation programs to better suit the needs of our cardiac patients.

Acknowledgement/Funding
Flinders University partnership grant and South Australian Department of Health Local Health Networks
P6222Changes in main CVD risk factors in Finland 1992–2017
Authors: Jousilahti P , Laatikainen T , Harkanen T , Borodulin K , Harald K , Koskinen S , Mannisto S , Peltonen M , Sundvall J , Valsta L , Vartiainen E 
Published: October 2019

Abstract

Background
Systematic monitoring of cardiovascular disease (CVD) risk factors started in eastern Finland already in the 1970s as part of the North Karelia Project. Later on risk factor monitoring was extended to other parts of the country.

Purpose
In this study we report the trends of main CVD risk factors in Finland from 1992 to 2017.

Methods
Study population consists of a population-based random sample of 31 402 men and women aged 25–64 years who participated in the FINRISK Studies from 1992 to 2012, and in the FinHealth Study in 2017. Data collection was done every five years. Participation rate decreased from 76% in 1992 to 56% in 2017. Study protocol included self-reported questionnaire data on smoking and other health behavior, measurements of height, weight and blood pressure, and venous blood sample for laboratory analysis. Blood pressure was measured two times, and the average of the measurements was calculated, total serum cholesterol was analyzed using enzymatic method, and LDL cholesterol was calculated using Friedewald formula.

Results
Smoking prevalence, mean blood pressure and total and LDL cholesterol levels declined markedly during the 25 year follow up but BMI, waist circumference and prevalence of obesity increased (table).
CVD risk factor change from 1992 to 2017 Risk factor Men 1992 Men 2017 p value Women 1992 Women 2017 p value Smoking (%) 36.7 20.6 <0.001 25.9 16.5 <0.001 SBP (mmHg) 136.6 131.2 <0.001 130.3 124.5 <0.001 DBP (mmHg) 82.7 81.6 <0.001 78.6 77.8 <0.001 Chol (mmol/L) 5.66 5.17 <0.001 5.42 5.18 <0.001 LDL chol (mmol/L) 3.54 3.16 <0.001 3.26 3.03 <0.001 BMI (kg/m2) 26.2 27.2 <0.001 25.1 26.4 <0.001 WC (cm) 92.8 96.1 <0.001 79.2 86.2 <0.001 Obesity (%) 15.7 23.2 <0.001 14.8 22.7 <0.001

Conclusions
The levels of main traditional CVD risk factors have markedly decreased among the Finnish population during the last 25 years but in the same time, obesity has become a major public health challenge.
P6252Diagnostic and prognostic accuracy of preoperative NT-proBNP added to revised cardiac risk index in elderly patients with hip fracture
Authors: Iglesias Garriz I , Ruiz-Villa M D , Idoate J , Jimenez Mola S , Sanchez-Robles A , Fernandez Vazquez F 
Published: October 2019

Abstract

Background
The identification of patients at highest risk after surgery for hip fracture could be of clinical value to implement post-operative actions to lessen mortality. We sought to investigate the utility of Revised Cardiac Risk Index (RCRI) and NT-proBNP in this scenario.

Methods
Patients older than 75 years with hip fracture treated with surgery were prospectively included. The end-point was overall mortality at 30 days.

Results
We enrolled 410 patients surgically-treated for hip fracture, 31 (7.6%) died during the 30-day follow-up. Patients who died were 3.5 years older (95% CI 1.3 to 5.6); p=0.001, and had a lower prevalence of diabetes mellitus.The prevalence of heart failure was more prevalent among patients who died: difference of proportions 35.7% (95% CI 16.0 to 55.3); p<0.001 and more patients were not in sinus rhythm with a difference of 25.4% (95% CI 5.6 to 45.1); p<0.001. Adding NT-proBNP to a logistic regression model with RCRI as an independent variable, improved the diagnostic and prognostic metrics, with significant changes in specificity (0.59 vs 0.70, p<0.001) and predictive values: positive likelihood ratio (LR) 1.89 vs 2.49, p<0.001, negative LR 0.38 vs 0.33, p<0.001. The C-statistic (0.69 vs 0.77, p=0.002) and the net reclassification improvement were also improved.

Conclusion
Adding preoperative NT-proBNP to RCRI to appraise the risk of overall 30-day mortality rate after hip surgery improves the prediction accuracy of RCRI alone.
P6257Low systolic blood pressure on admission as a predictor of outcome in octogenarian patients with heart failure and preserved ejection fraction
Authors: Tsuda K , Kanzaki Y , Maeda D , Akamatsu K , Nakayama S , Horai R , Sakane K , Ozeki T , Fujita S , Fujisaka T , Sohmiya K , Hoshiga M 
Published: October 2019

Abstract

Background
Heart failure (HF) is an epidemic in healthcare worldwide including Asia. It appears that HF will become more serious with aging of the population. The patients with heart failure and preserved ejection fraction (HFpEF) were older, more often female, and frequently have comorbidities including hypertension. However, lower systolic blood pressure (SBP) on admission is associated with poor outcomes in patients with HF. It remains unclear whether this association is similar in very elderly patients with HFpEF.

Purpose
To investigate clinical features and prognosis in octogenarian HFpEF subjects.

Methods
We analyzed 87 consecutive subjects aged 80 years or older who were hospitalized for acute decompensated HF with left ventricular ejection fraction (LVEF) ≥50% between 2015 and 2017. Clinical characteristics and a composite event of cardiac death and HF hospitalization were compared in two groups according to SBP cut-off of 140 mmHg on admission.

Results
The prevalence of lower SBP subjects (mean BP = 118 mmHg) and higher SBP (mean BP = 166 mmHg) subjects were 41.4% and 58.6%, respectively. Lower SBP subjects were more comorbid with atrial fibrillation (72.2 vs. 45.1%, p=0.01). In the lower SBP group, diuretics, mineralocorticoid receptor antagonists (MRA), beta-blockers and ACE inhibitors/ARBs were more commonly used than higher SBP group (Table). During the observational period (median = 1.0 year), lower SBP on admission was associated with a 2.65-fold [95% confidence interval (CI): 1.29–5.55, p=0.009] greater likelihood of experiencing the composite events of cardiac death and rehospitalization for HF (Figure). This observation was still consistent even after adjusting clinical demographics and comorbidity [hazard ratio = 2.95, 95% CI: 1.30–6.87, p=0.01].
Table 1 Lower SBP group (n=36) Higher SBP group (n=51) P-value Atrial fibrillation (%) 72.2 0.01 0.01 Loop diuretic (%) 97.1 83.7 0.08 MRA (%) 47.1 24.5 0.04 Beta-blocker (%) 52.9 44.9 0.51 ACE inhibitor/ARB (%) 59.2 29.4 0.01
Figure 1

Conclusions
In octogenarian patients with acute decompensated HF and preserved LVEF, SBP on admission less than 140 mmHg is significantly associated with poor outcomes. Future studies need to prospectively evaluate optimal SBP treatment goals in very elderly patients with HFpEF.
P6264Mitral regurgitation and prognosis after non-ST-segment elevation myocardial infarction in very old patients
Authors: Vera Sainz A , Diez Villanueva P , Ariza Sole A , Formiga F , Lopez Palop R , Marin F , Vidan M , Martinez Selles M , Salamanca J , Sionis A , Garcia Pardo H , Bueno H , Sanchis J , Abu Assi E , Alfonso F 
Published: October 2019

Abstract

Background
Mitral regurgitation (MR) after acute coronary syndromes is associated with adverse prognosis. However, the prognostic impact of MR in older patients with Non ST-segment Elevation Myocardial Infarction (NSTEMI) has not been well addressed.

Methods
The multicenter LONGEVO-SCA prospective registry included 532 unselected patients with NSTEMI aged ≥80 years. Echocardiography performed during admission quantified mitral valve parameters in 497 patients, who were classified according to mitral regurgitation (MR) status in two groups: significant (moderate or severe) or no significant MR (absent or mild). We evaluated the impact of MR status on mortality or readmission at 6-months.

Results
Mean age was 84.3±4.1 years, 308 (61.9%) were males. A total of 108 patients (21.7%) had significant MR. Compared with patients without significant MR these patients had lower systolic blood pressure (132±28 vs 141±27 mmHg), higher heart rate (82±21 vs 74±17 bpm), worse Killip class (≥II 49.5% vs 22.5%), lower ejection fraction (47±14% vs 55±11%), higher pulmonary pressure (42±15 vs 35±11 mmHg), as well as more frequent new onset atrial fibrillation (16.4% vs 7.2%) (all p values=0.001). Patients with significant MR also had higher in-hospital mortality (4.6% vs 1.3%, p=0.04) and longer hospital stay (median 8 [5–12] vs 6 [4–10] days, p=0.002),and higher mortality/readmission at 6 months (HR 1,54, 95% CI 1.09–2.18). However, after adjusting for potential confounders, this last association was not significant.

Conclusions
Significant MR is seen in about one fifth of octogenarians with NSTEMI. Patients with significant MR have a poor prognosis, which is mainly determined by their clinical characteristics.