bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tell me more! Assessing interactions with social robots from speech
Authors: Laban Guy , George Jean-Noël , Morrison Val , Cross Emily S. 
Published: December 2020

AbstractAs social robots are increasingly introduced into health interventions, one potential area where they might prove valuable is in supporting people’s psychological health through conversation. Given the importance of self-disclosure for psychological health, this study assessed the viability of using social robots for eliciting rich disclosures that identify needs and emotional states in human interaction partners. Three within-subject experiments were conducted with participants interacting with another person, a humanoid social robot, and a disembodied conversational agent (voice assistant). We performed a number of objective evaluations of disclosures to these three agents via speech content and voice analyses and also probed participants’ subjective evaluations of their disclosures to three agents. Our findings suggest that participants overall disclose more to humans than artificial agents, that agents’ embodiment influences disclosure quantity and quality, and that people are generally aware of differences in their personal disclosures to three agents studied here. Together, the findings set the stage for further investigation into the psychological underpinnings of self-disclosures to artificial agents and their potential role in eliciting disclosures as part of mental and physical health interventions.
Konsum von und Einstellungen zu nicht-verschriebenen aber verschreibungspflichtigen Mitteln zur Leistungssteigerung und Beruhigung bei Studierenden an acht deutschen Hochschulen
Authors: Helmer Stefanie M. , Czwikla Gesa , Pischke Claudia R. , Zeeb für das INSIST-Konsortium Hajo 
Published: December 2020

Zusammenfassung
Der Konsum von nicht-verschriebenen aber verschreibungspflichtigen Mitteln zur akademischen Leistungssteigerung (NVVML) und von Schlaf- und Beruhigungsmitteln (NVVSB) unter Studierenden ist ein bedeutendes Public Health-Problem. Im Rahmen der INSIST-Studie berichteten 3,7% der Studierenden aus acht Hochschulen in Deutschland jemals in ihrem Leben NVVML, während 6,8% berichteten, jemals NVVSB eingenommen zu haben. Der Großteil der Studierenden missbilligte den nicht-verschriebenen Konsum beider Substanzen.
„Pills & Powders“: Partydrogen und Prävention
Authors: Nunes Sonia 
Published: December 2020

Zusammenfassung
Die aktive Teilhabe am Nachtleben kann als Herausforderung für die Gesundheit angesehen werden. Neben Alkohol gehört auch der Konsum illegaler Partydrogen, wie Cannabis oder Ecstasy, für viele Jugendliche zum Feiern dazu. Gleichzeitig sind andere Wege in der Ansprache dieser Zielgruppe erforderlich, da junge Partygänger kaum von den Angeboten der klassischen Suchthilfe erreicht werden. Hierbei haben sich akzeptanzorientierte Präventionsangebote – wie z.B. MINDZONE - bewährt, die direkt in der Partyszene den Kontakt zu den jugendlichen Adressaten aufnehmen.
Evaluation of promethium-147 production as a by-product of the fission molybdenum-99 process in Tehran research reactor
Authors: Hosseini Seyed Ehsan , Ghannadi-Maragheh Mohammad , Bahrami-Samani Ali , Shirvani-Arani Simindokht 
Published: December 2020

Abstract
Molybdenum-99 and some other fission products such as promethium-147 are formed by the fission of 235U. Applying an efficient separation approach, the 147Pm can be isolated. The production of 147Pm as a by-product of previously optimized conditions for fission molybdenum-99 process is precisely evaluated. Considering the numerous radionuclides with various half-lives accompanying the 147Pm as impurities, a precise time window can be determined to perform an efficient separation process. The fission products activity calculations, using MCNPX and ORIGEN2.1 computer codes, were performed to achieve such a proper time window. Here, it is shown that 300 days after the end of bombardment (EOB), the radioactivity of the other radionuclides is reduced to 1% of 147Pm radioactivity. The chemical process needed to separate the remaining radionuclides is then explained in detail.
Nurses’ attitude toward spiritual care – a scoping review
Authors: Zumstein-Shaha Maya 
Published: December 2020

Abstract
In this paper, the nurses’ attitude toward spirituality and spiritual care is explored. Spirituality constitutes a widely discussed topic in nursing and several guidelines have emerged. However, spirituality remains contentious and spiritual care is rarely provided on a regular basis. Inquiring into nurses’ attitudes toward spirituality and spiritual care can be illuminating to improve the current situation. A scoping review according to Whittemore & Knafl (2005) was conducted in the databases Medline/PubMed and Google Scholar, as well as a hand search. A total of 42 publications from between 2000 and 2019 were identified, and critically appraised using reporting guidelines. For nurses, spirituality is necessary. Spirituality is inherent in nursing. Fears and apprehensions exist about addressing spirituality in nursing practice and providing spiritual care for patients. Ambiguous attitudes toward spirituality, lack of education and adequate language to address spirituality, limited recognition and lack of adequate structures are all contributing factors to these fears. Although spirituality is considered an important aspect of nursing, several impeding factors prevent addressing it in practice. Reflective practice, education and supporting structures promoting recognition are needed to improve the situation.
hnRNPLL controls pluripotency exit of embryonic stem cells by modulating alternative splicing of Tbx3 and Bptf
Authors: Wang Xue , Ping Changyun , Tan Puwen , Sun Chenguang , Liu Guang , Liu Tao , Yang Shuchun , Si Yanmin , Zhao Lijun , Hu Yongfei , Jia Yuyan , Wang Xiaoshuang , Zhang Meili , Wang Fang , Wang Dong , Yu Jia , Ma Yanni , Huang Yue 
Published: December 2020

AbstractThe regulatory circuitry underlying embryonic stem (ES) cell self‐renewal is well defined, but how this circuitry is disintegrated to enable lineage specification is unclear. RNA‐binding proteins (RBPs) have essential roles in RNA‐mediated gene regulation, and preliminary data suggest that they might regulate ES cell fate. By combining bioinformatic analyses with functional screening, we identified seven RBPs played important roles for the exit from pluripotency of ES cells. We characterized hnRNPLL, which mainly functions as a global regulator of alternative splicing in ES cells. Specifically, hnRNPLL promotes multiple ES cell‐preferred exon skipping events during the onset of ES cell differentiation. hnRNPLL depletion thus leads to sustained expression of ES cell‐preferred isoforms, resulting in a differentiation deficiency that causes developmental defects and growth impairment in hnRNPLL‐KO mice. In particular, hnRNPLL‐mediated alternative splicing of two transcription factors, Bptf and Tbx3, is important for pluripotency exit. These data uncover the critical role of RBPs in pluripotency exit and suggest the application of targeting RBPs in controlling ES cell fate.
Design and Development of a Protective Face Mask to Mitigate Community Spread and Prevent Wearer Infection from COVID - 19 Using Design Thinking
Authors: Brookstein David 
Published: December 2020

Relatively early during the start of the COVID-19 pandemic it was widely recognized that community spread could be mitigated by the widespread wearing of face masks. However, at first, they were difficult to procure and the CDC discouraged the use of masks for the general public since this might cause shortages for healthcare workers. Subsequently, the CDC suggested that cloth masks, without filters, should be used by the general public since these were considered ineffective for healthcare workers. Using the concepts of design thinking, effective protective face masks with filters were designed and developed using readily available materials that could be used by the general public.
Qualitative and quantitative characteristics of different types of tumor microvessels depending on the histological type of cervical cancer
Authors: Senchukova M. A. , Makarova E. V. , Shurygina E. I. , Volchenko N. N. 
Published: December 2020

Purpose of the study.To give a qualitative and quantitative assessment of different types of tumor microvessels depending on the histological type of cervical cancer (CC).Material and methods.The tumor samples from 76 patients with CC stage I–IIA who received the surgical treatment on the first phase were the object of study. The immunohistochemical study was performed using antibodies to CD34 and podoplanin. Statistical analysis of the data was performed using the Statistica 6.0 software.Results.In CC, the following types of tumor microvessels have been identified: normal microvessels, dilated capillaries (DCs) with a normal endothelial lining, DCs with a weak expression of CD34, DCs of contact type, capillaries in the solid component of tumor, the atypical dilated capillaries (ADCs), the structures with partial endothelial lining and the lymphatic capillaries in lymphoid and polymorphic cell infiltrates. It was found that DCs with a mild expression of CD34 (p=0.0005), DCs of contact type (p=0.000005), and capillaries in the solid component of tumor (p=0.006) were correlated with the prognosis in early CC. The detection frequency of this tumor microvessels was lower in more prognostically favorable squamous non-keratinizing CC, while in the prognostically unfavorable squamous cell keratinizing CC and adenocarcinoma of the cervix uteri, the higher DCs values with a mild expression of CD34 (р=0,004 and р=0.005, respectively) and DC of contact type (p=0.02 and p=0.14, respectively) were typical.Conclusion.We consider it is expedient to further study the relationship of different types of tumor microvessels with clinical and morphological characteristics and prognosis of cervical cancer.
Study of visual functions with multifocal versus monofocal intraocular lenses after phacoemulsification in patients with age-related cataract
Authors: Gupta Garima , Anand Neebha , Khurana Ashok Kumar , Gupta Jaya 
Published: December 2020

Early visual rehabilitation and targeting emmetropia using small incisions and foldable IOLs is the main objective of modern cataract surgery, the so termed ‘refractive cataract surgery’. This current single-center prospective study assessed the clinical outcomes and thus patient satisfaction of multifocal IOLs over monofocal IOLs. To study visual functions with a refractive –diffractive type multifocal versus monofocal intraocular lenses after phacoemulsification in patients with age related cataract. 40 patients undergoing phacoemulsification for decreased vision due to age related cataract were randomly divided into 2 groups. Patients in group 1 underwent multifocal IOL [refractive –diffractive type] implantation and patients in group 2 underwent confocal IOL implantation. Postoperatively, patients were followed up for 90 days and assessed for unaided visual acuity for distance, intermediate and near vision, contrast sensitivity using Pelli-robson chart. At the end of the study, uncorrected visual acuity for distance (UDVA) was 6/9 in 65% patients in group 1 while 50% had uncorrected visual acuity of 6/9 in group 2. Uncorrected intermediate visual acuity (UIVA) in group 1 was N10 or better in 55% patients while in group 2, 75% patients had N24. Uncorrected near visual acuity (UNVA) in group 1 was N6 in 35% patients and N8 in 35% while in group 2, 75% patients had N18 vision, A paramount statistical difference was seen in the two groups.(p=0.001). The mean contrast sensitivity in group 1 was 2.04+/-0.23 and group 2 was 2.20+/-0.07(although statistically significant but within normal limits). None of the patients in any group had any significant complaint of glare or haloes. Mutifocal IOLs decrease the spectacle dependence of patients without compromising the subjective visual functions
Research on Cross-Border Emergency Logistics Collaboration Mechanism under the Background of Belt One Road Initiative
Authors: Zhang Jiangze 
Published: December 2020

<p>Emergency logistics is a special part of the logistics system. When emergencies occur, emergency logistics is indispensable. Currently, the current situation of cross-border emergency logistics has many drawbacks. In order to further reduce the losses caused by emergencies, it is necessary to improve the cross-border emergency logistics system, in-depth analysis of the current problems in the four aspects of cross-border logistics management, systems, logistics information, and material distribution in countries along the Belt and Road Initiative, through the establishment of a cross-border emergency logistics coordination mechanism, relevant strategies are established to ensure the effective implementation of emergency logistics.</p>
Research on the Improvement of Risk Control Index System of Securities Companies
Authors: Hu Chenbang 
Published: December 2020

<p> With the deepening of the reform of the financial industry, regulatory agencies have not strictly controlled in accordance with the regulatory system. In the face of the ever-changing market environment and the continuous upgrading of the securities industry competition pattern, innovation and development ushered in new opportunities, but also brought some difficulties to the implementation of risk management measures in China. In addition, the development of new Internet economy features. Because the securities companies have not adapted to the new liquidity characteristics, they are insufficient to cope with the new liquidity risks. In addition, the financing channels of securities companies are single, without a good combination of financing channels, it is easy to bring greater risks. Secondly, the imperfection of internal control system and the lack of awareness of risk management and control of employees themselves also bring a lot of trouble to securities companies in risk management and control. To solve these problems, we should start from the root causes, improve the internal risk control, and at the same time, we need to work in the industry. The content of risk management is added in the threshold examination of personnel, and it is used as the assessment content in the subsequent assessment, which urges the staff to take risk control as their own responsibility.</p>
Gads Hill Center: Revisiting the Function and Cause of Social Settlements in a Time of COVID
Authors: Vidal de Haymes Maria Del Rosario , Garcia Maricela , Cornelius Llewelyn 
Published: December 2020

The Covid-19 pandemic has extended across the globe and has made visible the hyper vulnerability of socially marginalized groups, the inadequacy of public health systems, and the fragility of national and global economic systems. Inflection points, such as the pandemic, often signal that the affected sectors, in this case nation states and their social institutions, regional bodies, and international organizations, must make a fundamental examine and consider the actions needed to strengthen their institutions and footing. In this case study we present how this historical moment has lead a 122 year old American social settlement to reexamine their role and model of practice in an effort to continue to contribute to meaningful changes that diminish human suffering and vulnerability, while advancing the rights and flourishing of the communities of color that they accompany.
Enhancement of Natural GABA Production in Yogurt by Simple Carbohydrates and Metabolomics Profiling During Fermentation of Novel, Self-Cloned Lactobacillus Plantarum Taj-Apis362
Authors: Hussin Farah , Chay Shyan , Ghani Mohd Syahmi Abdul , Hussin Anis Meor , Ibadullah Wan Wan , Muhialdin Belal , Saari Nazamid 
Published: December 2020

Abstract
This study aimed to enhance natural GABA production in yogurt by adding glucose (2%, w/v) in the presence of low glutamate concentration (11.5mM vs. reported range of 32–507 mM) without the need of pyridoxal 5’-phosphate (PLP) cofactor, producing GABA at 58.56 mg/100g, significantly surpassing that of PLP (48.01 mg/100g). Simulated gastrointestinal digestion showed a non-significant reduction in GABA content and probiotic viability, demonstrating resistance towards a high acidic environment (pH 1.2). Refrigerated storage up to 28 days revealed an improved GABA production of 83.65 mg/100g compared to fresh GABA-rich yogurt prepared at day 1 (59.00 mg/100g). Metabolomics profiling revealed different metabolite concentrations of amino acid, sugar and organic acid in GABA-rich and standard yogurt. The results successfully mitigate the over-use of glutamate substrate and omit the use of PLP cofactor during GABA enhancement in a fermented food system, offering an economical approach to produce a probiotic-rich dairy food with anti-hypertensive effect which is susceptible to manage stress and prevent cardiovascular disease.
Single-run separation and quantification of 14 cannabinoids using affinity non-aqueous capillary electrophoresis
Authors: Zaripov Emil , Lee Tiah , Dou Yuchu , Harris Cory , Egorov Artem , Berezovski Maxim 
Published: December 2020

Abstract
The legalization of cannabis has magnified the importance of determining the quantity and identification of cannabinoids. Both industry and consumers are highly interested in the content of cannabinoids available in their products, while health care professionals and regulators are concerned with the safety of cannabis. Quantification of major cannabinoids in products answers some of these concerns. Currently, popular methods of quantifying cannabinoids use high-pressure liquid chromatography (HPLC). Still, these HPLC methods are limited to quantifying a small number of cannabinoids unless more powerful but more costly instruments are employed to achieve better analysis, such as UHPLC and mass spectrometry. We propose a quick method that successfully separates and quantifies 14 cannabinoids in a single run using capillary electrophoresis (CE) coupled with a UV detector in 25 minutes. Our CE method demonstrated the limit of detection between 1.2–1.8 µg/mL, with the detection range reaching up to 50 µg/mL.
Postoperative around-the-clock administration of intravenous acetaminophen for pain control following robot-assisted radical prostatectomy
Authors: Inoue Shogo , Miyoshi Hirotsugu , Hieda Keisuke , Hayashi Tetsutaro , Tsutsumi Yasuo , Teishima Jun 
Published: December 2020

Abstract
The objective of this study was to examine the impact of around-the-clock (ATC) administration of intravenous (IV) acetaminophen following Robot-assisted radical prostatectomy (RARP). Intravenous infusion of acetaminophen was started on the day of the operation at 1000 mg/dose every 6 hours, and the infusion was continued on a fixed schedule until postoperative day 2 AM. We compared 127 patients who were administered IV acetaminophen on a fixed schedule (ATC group) with 485 patients who were administered analgesic drugs only as needed (PRN group). We investigated postoperative pain intensity and additional analgesic consumption on postoperative day 0, 1, 2, 3, and 5 between the two groups. Postoperative pain scores were significantly lower in the ATC group than in the PRN group at 1 and 2 days, and this period matched the duration of ATC administration of IV acetaminophen. Postoperative frequency of rescue analgesia was significantly lower in the ATC group than in the PRN group at postoperative 0, 1, and 2 days. ATC administration of IV acetaminophen has the potential to be a very versatile and valuable additional dose to achieve appropriate postoperative analgesia in patients with RARP.
Cisplatin Inhibits Bladder Cancer Proliferation Through cGAS-STING Pathway.
Authors: FU GUANGHOU , CHEN XIAOYI , XU ZHIJIE , SU JUNJIE , TIAN JUNJIE , SHI YUE , XU CONGCONG , PAN HAO , Baiye Jin 
Published: December 2020

Abstract
Background

Cisplatin is a commonly used adjuvant chemotherapy for advanced bladder cancer, but its immune related mechanism is still unclear. Exploration the immune effects of cisplatin in bladder cancer would complement the comprehensive mechanism of cisplatin and provide the basis for combination therapy of cisplatin and immunotherapy in bladder cancer.
Methods

We confirmed the immune effects of cisplatin on T24 and TCCSUP bladder cancer cell lines in vitro and exploration the important function of these immune effects in bladder cancer microenvironment in mice tumor model.
Results

We found cisplatin induced immune response in bladder cancer by RNA sequencing, and validated cGAS-STING signal was deeply involved in this response. Cisplatin induced cGAS-STING signal inhibited the proliferation of bladder cancer and increased the infiltration percentages of CD8 + T cells and dendritic cells in transplantation mice tumor model. Accumulation of dsDNA and the release of chromatin bound cGAS are important to activate downstream STING.
Conclusion

Our findings indicated a cisplatin related immune effects in bladder cancer, cisplatin combined with immunotherapy might have a synergistic effect for bladder cancer therapy.
Sociodemographic and Economic Traits That Affect Malaria Prevalence in Sussundenga Village, Mozambique.
Authors: Ferrao Joao Luis , Earland Dominique , Novela Anisio , Mendes Roberto , Ballat Marcos F. , Tungaza Alberto , Bibe Albino , Muhiro Valy , Searle Kelly 
Published: December 2020

Abstract
Malaria is still one of the leading causes of mortality and morbidity in Mozambique with the 5 th highest prevalence in the world, with little progress in malaria control over the past 20 years. Sussundenga village is one of most affected areas, and lies along the Zimbabwe border, making evaluation of malaria transmission and control policies integral for regional efforts. The objective of this study was to map and quantify malaria parasite prevalence and model its relationship with sociodemographic and economic traits in Sussundenga Village. Houses in the study area were digitalized and enumerated using GoogleEarth Pro TM . A sample of 125 houses was drawn to conduct a community survey of P. falciparum parasite prevalence using rapid diagnostic test (RDT). During the survey, a questionnaire was conducted to assess the socio-demographic and economic traits of the participants. Descriptive statistics were analyzed and logistic regression was performed to establish the relationship between positive cases and the traits. Using GIS a map the prevalence of malaria was produced. The analysis was carried out using SPSS version 20 package and ArcGis 10.7.1. 358 participants were enrolled, completed the survey, and were tested for malaria. The overall P. falciparum prevalence was 31.6 % and spatiality identified. Half of the malaria positive cases occurred in age group 5 to 14, 40 % more than expected and age group over 24 accounted for 17.6 % the cases, around 50 % less than expected. The model explained 15 % of the variance in malaria positive cases and sensitivity of the final model was 91.8 %. The increase in malaria treated cases, having paid employment, education level and age category, will decrease the probability of malaria positive cases in Sussundenga Village. Conclusion In this area the highest burden of P. falciparum infection was among those 5-14 years old. Malaria infection was related to socio-demographic and economic traits. Targeting malaria control at community level can contributed better than waiting for cases at health centers. These finding can be used to guide more effective interventions in this region.