bluuebunny/crossref_metadata_2025_split huggingface dataset:
L2 exposure modulates the scope of planning during first and second language production
Authors: Gilbert Annie C. , Cousineau-Perusse Maxime , Titone Debra 
Published: February 2020

AbstractThe psycholinguistic literature suggests that the length of a to-be-spoken phrase impacts the scope of speech planning, as reflected by different patterns of speech onset latencies. However, it is unclear whether such findings extend to first and second language (L1, L2) speech planning. Here, the same bilingual adults produced multi-phrase numerical equations (i.e., with natural break points) and single-phrase numbers (without natural break points) in their L1 and L2. For single-phrase utterances, both L1 and L2 were affected by L2 exposure. For multi-phrase utterances, L1 scope of planning was similar to what has been previously reported for monolinguals; however, L2 scope of planning exhibited variable patterns as a function of individual differences in L2 exposure. Thus, the scope of planning among bilinguals varies as a function of the complexity of their utterances: specifically, by whether people are speaking in their L1 or L2, and bilingual language experience.
Neuroendocrine carcinoma of the uterine cervix: 15-year experience from a tertiary care centre in Southern India
Authors: Jacob Sobin V. , Sathyamurthy Arvind , Ramireddy Jeba Karunya , Thomas Anitha , Singh Kaalindi , Ram Thomas Samuel 
Published: February 2020

AbstractAim:To analyse the presentation, treatment strategies and outcomes of neuroendocrine carcinoma of cervix treated with multi-modality approach at our institute.Materials and methods:The data of patients diagnosed to have cervical cancer between October 2004 and November 2018 were retrieved, and 14 patients of neuroendocrine carcinoma cervix who received treatment in our institution were identified. The patients were analysed based on demographic characteristics, disease stage, pathological characteristics, treatment and follow-up. The median overall survival and disease-free survival were calculated.Results:Median follow-up period was 8 months (range 1–52 months). Six patients died within 4 months of completion of treatment due to disease progression. Median overall survival was 12 months and median disease-free interval was 5·5 months. Four of the patients who underwent combined modality treatment consisting of neoadjuvant chemotherapy, concurrent chemoradiation therapy and brachytherapy are still on regular follow-up and are disease-free.Conclusion:Neuroendocrine carcinoma of the cervix is a rare but aggressive histological subtype. Combined modality approach with judicious use of systemic chemotherapy along with surgery and radiation therapy is essential for optimal outcomes.
Global Simulation of Electron Cyclotron Harmonic Wave Instability in a Storm‐Time Magnetosphere
Authors: Liu Xu , Chen Lunjin , Engel Miles A. , Jordanova Vania K. 
Published: February 2020

AbstractElectron cyclotron harmonic (ECH) waves are electrostatic emissions between the ECHs and play a dominant role for precipitating energetic electrons in the magnetotail. Statistically, the ECH wave intensity is stronger at nightside and dawnside than at dayside and duskside. In this study, we, for the first time, simulate the global ECH wave evolution during a geomagnetic storm event using Ring current Atmosphere interactions Model with Self‐Consistent Magnetic field (RAM‐SCB) combined with a linear growth rate solver. We find that the simulation results are generally consistent with the statistical and real‐time observations. The ECH wave instability is much stronger at nightside and dawnside, compared to the instability at dayside and duskside. Before a geomagnetic storm (quiet time), the unstable regions of the ECH waves lie beyond
with a weak instability level. During the main phase of a geomagnetic storm, the unstable regions can extend to a lower altitude (
) with a strong instability level. During the recovery phase, the unstable regions return to
. We also find that the inner boundary of unstable ECH wave regions is coincident with the plasmapause location during the whole geomagnetic storm event.
Energetic Particles and Acceleration Regions Over Jupiter's Polar Cap and Main Aurora: A Broad Overview
Authors: Mauk B. H. , Clark G. , Gladstone G. R. , Kotsiaros S. , Adriani A. , Allegrini F. , Bagenal F. , Bolton S. J. , Bonfond B. , Connerney J. E. P. , Ebert R. W. , Haggerty D. K. , Kollmann P. , Kurth W. S. , Levin S. M. , Paranicas C. P. , Rymer A. M. 
Published: February 2020

AbstractPrevious Juno mission event studies revealed powerful electron and ion acceleration, to 100s of kiloelectron volts and higher, at low altitudes over Jupiter's main aurora and polar cap (PC; poleward of the main aurora). Here we examine 30–1200 keV JEDI‐instrument particle data from the first 16 Juno orbits to determine how common, persistent, repeatable, and ordered these processes are. For the PC regions, we find (1) upward electron angle beams, sometimes extending to megaelectron volt energies, are persistently present in essentially all portions of the polar cap but are generated by two distinct and spatially separable processes. (2) Particle evidence for megavolt downward electrostatic potentials are observable for 80% of the polar cap crossings and over substantial fractions of the PC area. For the main aurora, with the orbit favoring the duskside, we find that (1) three distinct zones are observed that are generally arranged from lower to higher latitudes but sometimes mixed. They are designated here as the diffuse aurora (DifA), Zone‐I (ZI(D)) showing primarily downward electron acceleration, and Zone‐II (ZII(B)) showing bidirectional acceleration with the upward intensities often greater than downward intensities. (2) ZI(D) and ZII(B) sometimes (but not always) contain, respectively, downward electron inverted Vs and downward proton inverted Vs, (potentials up to 400 kV) but, otherwise, have broadband distributions. (3) Surprisingly, both ZI(D) and ZII(B) can generate equally powerful auroral emissions. It is suggested but demonstrated for intense portions of only one auroral crossing, that ZI(D) and ZII(B) are associated, respectively, with upward and downward electric currents.
Twentieth Century Black Carbon and Dust Deposition on South Cascade Glacier, Washington State, USA, as Reconstructed From a 158‐m‐Long Ice Core
Authors: Kaspari S. D. , Pittenger D. , Jenk T. M. , Morgenstern U. , Schwikowski M. , Buenning N. , Stott L. 
Published: February 2020

AbstractLight absorbing particles (LAPs) include black carbon (BC) and mineral dust and are of interest due to their positive radiative forcing and contribution to albedo reductions and snow and glacier melt. This study documents historic BC and dust deposition as well as their effect on albedo on South Cascade Glacier (SCG) in Washington State (USA) through the analysis of a 158‐m (139.5‐m water equivalent [w.e.]) ice core extracted in 1994 and spanning the period 1840–1991. Peak BC deposition occurred between 1940 and 1960, when median BC concentrations were 16 times higher than background, likely dominated by domestic coal and forest fire emissions. Post 1960 BC concentrations decrease, followed by an increase from 1977 to 1991 due to melt consolidation and higher emissions. Differences between the SCG record and BC emission inventories, as well as ice core records from other regions, highlight regional differences in the timing of anthropogenic and biomass BC emissions. Dust deposition on SCG is dominated by local sources and is variable throughout the record. Albedo reductions from LAP are dominated by dust deposition, except during high BC deposition events from forest fires and during 1940–1960 when BC and dust similarly contribute to albedo reductions. This study furthers understanding of the factors contributing to historical snowmelt and glacier retreat in the Cascades and demonstrates that ice cores retrieved from temperate glaciers have the potential to provide valuable records of LAP deposition.
Development of a Bowtie Inversion Technique for Real‐Time Processing of the GOES‐16/‐17 SEISS MPS‐HI Electron Channels
Authors: Boudouridis A. , Rodriguez J.V. , Kress B.T. , Dichter B.K. , Onsager T.G. 
Published: February 2020

AbstractThe Space Environment In‐Situ Suite on the Geostationary Operational Environmental Satellite (GOES)‐R series of satellites includes a new instrument for measuring radiation belt electrons and protons, the Magnetospheric Particle Sensor–High Energy (MPS‐HI). The MPS‐HI electron channels cover the energy range 50 keV to 4 MeV. The conversion of raw MPS‐HI electron telescope counts to fluxes is based on the so‐called bowtie technique. The goal of the bowtie analysis is to calculate for each energy channel an energy/geometric factor pair applicable to a wide range of energy spectra and for which the geometric factor error is minimized. Rather than using idealized analytical spectral functions, we use observed high‐resolution spectra from the cross‐calibrated Combined Release and Radiation Effects Satellite (CRRES) Medium Electron Sensor A and High Energy Electron Fluxmeter data set from the period 1990–1991, restricted to 6 < L < 8. One thousand randomly selected CRRES spectra are used to perform the bowtie analysis and determine the MPS‐HI channel energy/geometric factor characteristics. The results are used to convert the GOES‐16/‐17 MPS‐HI electron counts to fluxes. The same bowtie technique is used to calculate effective energies and geometric factors for the GOES‐13/‐14 Magnetospheric Electron Detector ME1‐ME5 (30–600 keV) electron channels. We compare the fluxes from the various spacecraft (GOES‐16/‐13, GOES‐17/‐14, and GOES‐16/‐17) over periods of several months to determine the applicability and utility of the bowtie analysis. Finally, we compare the GOES‐16/‐13 fluxes during 22 days of near conjunction. All comparisons show good agreement among the various satellite data sets.
High‐Frequency Waves Driven by Agyrotropic Electrons Near the Electron Diffusion Region
Authors: Dokgo Kyunghwan , Hwang Kyoung‐Joo , Burch James L. , Yoon Peter H. , Graham Daniel B. , Li Wenya 
Published: February 2020

AbstractNational Aeronautics and Space Administration's Magnetosphere Multiscale mission reveals that agyrotropic electrons and intense waves are prevalently present in the electron diffusion region. Prompted by two distinct Magnetosphere Multiscale observations, this letter investigates by theoretical means and the properties of agyrotropic electron beam‐plasma instability and explains the origin of different structures in the wave spectra. The difference is owing to the fact that in one instance, a continuous beam mode is excited, while in the other, discrete Bernstein modes are excited, and the excitation of one mode versus the other depends on physical input parameters, which are consistent with observations. Analyses of dispersion relations show that the growing mode becomes discrete when the maximum growth rate is lower than the electron cyclotron frequency. Making use of particle‐in‐cell simulations, we found that the broadening angle
in the gyroangle space is also an important factor controlling the growth rate. Ramifications of the present finding are also discussed.
Interfacial Dzyaloshinskii-Moriya interaction arising from rare-earth orbital magnetism in insulating magnetic oxides
Authors: Caretta Lucas , Rosenberg Ethan , Büttner Felix , Fakhrul Takian , Gargiani Pierluigi , Valvidares Manuel , Chen Zhen , Reddy Pooja , Muller David A. , Ross Caroline A. , Beach Geoffrey S. D. 
Published: February 2020

AbstractThe Dzyaloshinskii-Moriya interaction (DMI) is responsible for exotic chiral and topological magnetic states such as spin spirals and skyrmions. DMI manifests at metallic ferromagnet/heavy-metal interfaces, owing to inversion symmetry breaking and spin-orbit coupling by a heavy metal such as Pt. Moreover, in centrosymmetric magnetic oxides interfaced by Pt, DMI-driven topological spin textures and fast current-driven dynamics have been reported, though the origin of this DMI is unclear. While in metallic systems, spin-orbit coupling arises from a proximate heavy metal, we show that in perpendicularly-magnetized iron garnets, rare-earth orbital magnetism gives rise to an intrinsic spin-orbit coupling generating interfacial DMI at mirror symmetry-breaking interfaces. We show that rare-earth ion substitution and strain engineering can significantly alter the DMI. These results provide critical insights into the origins of chiral magnetism in low-damping magnetic oxides and identify paths toward engineering chiral and topological states in centrosymmetric oxides through rare-earth ion substitution.
Salamanders and other amphibians are aglow with biofluorescence
Authors: Lamb Jennifer Y. , Davis Matthew P. 
Published: February 2020

AbstractBiofluorescence is the absorption of electromagnetic radiation (light) at one wavelength followed by its reemission at a lower energy and longer wavelength by a living organism. Previous studies have documented the widespread presence of biofluorescence in some animals, including cnidarians, arthropods, and cartilaginous and ray-finned fishes. Many studies on biofluorescence have focused on marine animals (cnidarians, cartilaginous and ray-finned fishes) but we know comparatively little about the presence of biofluorescence in tetrapods. We show for the first time that biofluorescence is widespread across Amphibia, with a focus on salamanders (Caudata), which are a diverse group with a primarily Holarctic distribution. We find that biofluorescence is not restricted to any particular family of salamanders, there is striking variation in their fluorescent patterning, and the primary wavelengths emitted in response to blue excitation light are within the spectrum of green light. Widespread biofluorescence across the amphibian radiation is a previously undocumented phenomenon that could have significant ramifications for the ecology and evolution of these diverse and declining vertebrates. Our results provide a roadmap for future studies on the characterization of molecular mechanisms of biofluorescence in amphibians, as well as directions for investigations into the potential impact of biofluorescence on the visual ecology and behavior of biofluorescent amphibians.
A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma
Authors: Das Mahapatra Kunal , Pasquali Lorenzo , Søndergaard Jonas Nørskov , Lapins Jan , Nemeth István Balazs , Baltás Eszter , Kemény Lajos , Homey Bernhard , Moldovan Liviu-Ionut , Kjems Jørgen , Kutter Claudia , Sonkoly Enikö , Kristensen Lasse Sommer , Pivarcsi Andor 
Published: February 2020

AbstractCutaneous Squamous Cell Carcinoma (cSCC) is the most common and fastest-increasing cancer with metastatic potential. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are novel regulators of gene expression. To identify mRNAs, lncRNAs and circRNAs, which can be involved in cSCC, RNA-seq was performed on nine cSCCs and seven healthy skin samples. Representative transcripts were validated by NanoString nCounter assays using an extended cohort, which also included samples from pre-cancerous skin lesions (actinic keratosis). 5,352 protein-coding genes, 908 lncRNAs and 55 circular RNAs were identified to be differentially expressed in cSCC. Targets of 519 transcription factors were enriched among differentially expressed genes, 105 of which displayed altered level in cSCCs, including fundamental regulators of skin development (MYC, RELA, ETS1, TP63). Pathways related to cell cycle, apoptosis, inflammation and epidermal differentiation were enriched. In addition to known oncogenic lncRNAs (PVT1, LUCAT1, CASC9), a set of skin-specific lncRNAs were were identified to be dysregulated. A global downregulation of circRNAs was observed in cSCC, and novel skin-enriched circRNAs, circ_IFFO2 and circ_POF1B, were identified and validated. In conclusion, a reference set of coding and non-coding transcripts were identified in cSCC, which may become potential therapeutic targets or biomarkers.
VEGF-A165b levels are reduced in breast cancer patients at primary diagnosis but increase after completion of cancer treatment
Authors: Karsten Maria Margarete , Beck Maximilian Heinz , Rademacher Angela , Knabl Julia , Blohmer Jens-Uwe , Jückstock Julia , Radosa Julia Caroline , Jank Paul , Rack Brigitte , Janni Wolfgang 
Published: February 2020

AbstractThe antiangiogenic splice variant VEGF-A165b is downregulated in a variety of cancer entities, but little is known so far about circulating plasma levels. The present analysis addresses this question and examines circulating VEGF-A/VEGF-A165b levels in a collective of female high-risk breast cancer patients over the course of treatment. Within the SUCCES-A trial 205 patients were recruited after having received primary breast surgery. Using ELISA VEGF-A/VEGF-A165b concentrations were determined and correlated to clinical characteristics (1) before adjuvant chemotherapy, (2) four weeks and (3) two years after therapy and compared to healthy controls (n = 107). VEGF165b levels were significantly elevated after completion of chemotherapy. Within the breast cancer cohort, VEGF-A165b levels increased two years after completion of chemotherapy. VEGF-A plasma concentrations were significantly elevated in the breast cancer cohort at all examined time points and decreased after treatment. VEGF-A levels two years after chemotherapy correlated with increased cancer related mortality, no such correlation could be found between VEGF-A165b and the examined clinical characteristics. Compared to controls, VEGF-A/VEGF-A165b ratios were decreased in patients before and after chemotherapy. Our data suggests that circulating VEGF-A165b is significantly reduced in women with primary breast cancer at time of diagnosis; furthermore, levels change during adjuvant treatment.
Respiratory mycobiome and suggestion of inter-kingdom network during acute pulmonary exacerbation in cystic fibrosis
Authors: Soret Perrine , Vandenborght Louise-Eva , Francis Florence , Coron Noémie , Enaud Raphael , Avalos Marta , Schaeverbeke Thierry , Berger Patrick , Fayon Michael , Thiebaut Rodolphe , Delhaes Laurence ,   The Mucofong Investigation Group, Chabe Magali , Audebert Christophe , Durand-Joly Isabelle , Boldron Amale , Pin Isabelle , Cognet Odile , Pelloux Herve , Prevotat Anne , Wallaert Benoit , Wizla Nathalie , Thumerelle Caroline , Turck Dominique 
Published: February 2020

AbstractLung infections play a critical role in cystic fibrosis (CF) pathogenesis. CF respiratory tract is now considered to be a polymicrobial niche and advances in high-throughput sequencing allowed to analyze its microbiota and mycobiota. However, no NGS studies until now have characterized both communities during CF pulmonary exacerbation (CFPE). Thirty-three sputa isolated from patients with and without CFPE were used for metagenomic high-throughput sequencing targeting 16S and ITS2 regions of bacterial and fungal rRNA. We built inter-kingdom network and adapted Phy-Lasso method to highlight correlations in compositional data. The decline in respiratory function was associated with a decrease in bacterial diversity. The inter-kingdom network revealed three main clusters organized around Aspergillus, Candida, and Scedosporium genera. Using Phy-Lasso method, we identified Aspergillus and Malassezia as relevantly associated with CFPE, and Scedosporium plus Pseudomonas with a decline in lung function. We corroborated in vitro the cross-domain interactions between Aspergillus and Streptococcus predicted by the correlation network. For the first time, we included documented mycobiome data into a version of the ecological Climax/Attack model that opens new lines of thoughts about the physiopathology of CF lung disease and future perspectives to improve its therapeutic management.
Sodium-hydrogen exchanger 6 (NHE6) deficiency leads to hearing loss, via reduced endosomal signalling through the BDNF/Trk pathway
Authors: Kucharava Krystsina , Brand Yves , Albano Giuseppe , Sekulic-Jablanovic Marijana , Glutz Andrea , Xian Xunde , Herz Joachim , Bodmer Daniel , Fuster Daniel G. , Petkovic Vesna 
Published: February 2020

AbstractAcid-base homeostasis is critical for normal growth, development, and hearing function. The sodium–hydrogen exchanger 6 (NHE6), a protein mainly expressed in early and recycling endosomes, plays an important role in regulating organellar pH. Mutations in NHE6 cause complex, slowly progressive neurodegeneration. Little is known about NHE6 function in the mouse cochlea. Here, we found that all NHE isoforms were expressed in wild-type (WT) mouse cochlea. Nhe6 knockout (KO) mice showed significant hearing loss compared to WT littermates. Immunohistochemistry in WT mouse cochlea showed that Nhe6 was localized in the organ of Corti (OC), spiral ganglion (SG), stria vascularis (SV), and afferent nerve fibres. The middle and the inner ears of WT and Nhe6 KO mice were not different morphologically. Given the putative role of NHE6 in early endosomal function, we examined Rab GTPase expression in early and late endosomes. We found no change in Rab5, significantly lower Rab7, and higher Rab11 levels in the Nhe6 KO OC, compared to WT littermates. Because Rabs mediate TrkB endosomal signalling, we evaluated TrkB phosphorylation in the OCs of both strains. Nhe6 KO mice showed significant reductions in TrkB and Akt phosphorylation in the OC. In addition, we examined genes used as markers of SG type I (Slc17a7, Calb1, Pou4f1, Cal2) and type II neurons (Prph, Plk5, Cacna1g). We found that all marker gene expression levels were significantly elevated in the SG of Nhe6 KO mice, compared to WT littermates. Anti-neurofilament factor staining showed axon loss in the cochlear nerves of Nhe6 KO mice compared to WT mice. These findings indicated that BDNF/TrkB signalling was disrupted in the OC of Nhe6 KO mice, probably due to TrkB reduction, caused by over acidification in the absence of NHE6. Thus, our findings demonstrated that NHEs play important roles in normal hearing in the mammalian cochlea.
Effects of Oxygen Modification on the Structural and Magnetic Properties of Highly Epitaxial La0.7Sr0.3MnO3 (LSMO) thin films
Authors: Kumari Shalini , Mottaghi Navid , Huang Chih-Yeh , Trappen Robbyn , Bhandari Ghadendra , Yousefi Saeed , Cabrera Guerau , Seehra Mohindar S. , Holcomb Mikel B. 
Published: February 2020

AbstractLa0.7Sr0.3MnO3, a strong semi-metallic ferromagnet having robust spin polarization and magnetic transition temperature (TC) well above 300 K, has attracted significant attention as a possible candidate for a wide range of memory, spintronic, and multifunctional devices. Since varying the oxygen partial pressure during growth is likely to change the structural and other physical functionalities of La0.7Sr0.3MnO3 (LSMO) films, here we report detailed investigations on structure, along with magnetic behavior of LSMO films with same thickness (~30 nm) but synthesized at various oxygen partial pressures: 10, 30, 50, 100, 150, 200 and 250 mTorr. The observation of only (00 l) reflections without any secondary peaks in the XRD patterns confirms the high-quality synthesis of the above-mentioned films. Surface morphology of the films reveals that these films are very smooth with low roughness, the thin films synthesized at 150 mTorr having the lowest average roughness. The increasing of magnetic TC and sharpness of the magnetic phase transitions with increasing oxygen growth pressure suggests that by decreasing the oxygen growth pressure leads to oxygen deficiencies in grown films which induce oxygen inhomogeneity. Thin films grown at 150 mTorr exhibits the highest magnetization with TC = 340 K as these thin films possess the lowest roughness and might exhibit lowest oxygen vacancies and defects. Interpretation and significance of these results in the 30 nm LSMO thin films prepared at different oxygen growth pressures are also presented, along with the existence and growth pressure dependence of negative remanent magnetization (NRM) of the above-mentioned thin films.