bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimally Invasive Radiofrequency Ablation for Large Thyroid Toxic Adenoma
Authors: Belitova M. , Ivanov S. , Marinov Ts. , Popov T. , Pandev R. 
Published: October 2019

Abstract

Background: Most thyroid nodules are benign and do not need intervention. Toxic adenoma and toxic multinodular goiter (MNG) are common causes of hyperthyroidism, second in prevalence only to Graves’ disease. Toxic adenoma and MNG are the result of focal or diffuse hyperplasia of thyroid follicular cells whose functional capacity is independent from regulation by the thyroid stimulating hormone (TSH). When conservative treatment modalities fail to ensure an euthyroid state, surgical intervention is required, typically surgical left or right thyroid lobectomy. Radiofrequency ablation (RFA) is a new percutaneous treatment option that results in thermal tissue necrosis and fibrosis. As a result of this process, the thyroid nodules shrink.

Case presentation: We describe a case of a young woman with a large toxic thyroid adenoma who refused surgery. She was admitted to a one-day surgery unit and underwent radiofrequency ablation under total intravenous anesthesia. Using “moving shot technique” the procedure went uneventfully and the toxic adenoma displayed a significant volume reduction with resolution of the hyperthyroid symptoms. The patient also reported a significant improvement of her neck symptoms (from 7/10 to 1/10 on a Visual Analogue Scale).

Conclusions: Radiofrequency ablation is a new, well tolerated, safe and effective treatment option in selected patients with benign thyroid nodules, toxic adenomas of the thyroid gland and multinodular goiter. To the best of our knowledge, this is the first time such treatment modality is used in Bulgaria.
Calculation Approaches of the Probable Maximum Discharge of Spring Flood at Ungauged Sites in the Southern Buh River Basin, Ukraine
Authors: Gorbachova Liudmyla , Khrystyuk Borys 
Published: October 2019

Abstract
Calculation of probable maximum discharge of spring flood are the great practical importance, since it is the basis to plan and design of different hydraulic structures, such as dams, culverts, urban and agriculture drainage systems, etc. Thus, the updating of the methodical approaches and parameters of the empirical formulas which using in the determining of the probable maximum discharge of spring flood at ungauged sites of the river basin is an actual task. In this paper for the Southern Buh River Basin were updated the parameters of the reduction formula and the limiting intensity formula of streamflow which are using to calculated of the probable maximum discharge of spring flood at ungauged basin in Ukraine. The presented results illustrate that parameters of empirical formulas that were calculated according to modern observation series (since the beginning of the observations to 2010) in comparison with previously received (since the beginning of the observations to 1980) have significant changes. We found out that it is due to cyclical of the long-term fluctuations of the maximum streamflow of spring flood in the Southern Buh River Basin. We also illustrated that for the small ungauged basins have the difficulties with the choice of rivers-analogues.
The Flooding Risk in the City of Relizane (Algeria)
Authors: Baki Touhami , Rezini Djelloul 
Published: October 2019

Abstract
The town of Relizane was built near Oued Mina, upstream of which is erected a dam of Sidi M'hamed Benaouda; while the city was protected in its time by a dike dating from the colonial period. Local authorities have recovered the land near the floodplain by building a new dike replacing the old one. However, flood risks persist on the city. Flood risk management plans for this new area should be provided for better protection of citizens and property.
Disabled Population in India: A Regional Analysis
Authors: Ariz Dilshad 
Published: October 2019

Abstract
Disability is a medical term in India and the person with impairment is considered to be disabled. India is still following the medical model of disability which is the oldest model of disability and highly criticized for providing a narrow definition for disability. Based on this model, Census of India 2011 has given eight categories of disabled population. This study is based on secondary sources of data from Census of India 2011 and Ministry of Social Justice and Empowerment. The principal objective of this paper is to understand and analyze the regional variation of disabled population of India and the location of national institutions for the disabled. Research reveals that the highest disability concentration is found in the central zone and the eastern zone of India. Moreover, types of disabled population also show a spatial pattern like seeing disabled population are concentrated in the eastern zone of India and speech disabled population are concentrated in the western zone of India. Further the result of study reveals that the number of institutes for the disabled are insufficient and the location does not align with the spatial pattern of types of disabled. The researcher suggests that there is a need for more national institutions to set up and location of the institutions must align with the spatial pattern of the types of disability.
Determination of non-cholesterol sterols in serum and HDL fraction by LC/MS-ms: Significance of matrix-related interferences
Authors: Vladimirov Sandra , Gojkovic Tamara , Zeljkovic Aleksandra , Jelic-Ivanovic Zorana , Spasojevic-Kalimanovska Vesna 
Published: October 2019

Summary

Background
Non-cholesterol sterols (NCS) are promising biomarkers for estimation of cholesterol homeostasis properties. In addition, determination of NCS in high-density lipoprotein (HDL) fraction (HDL-NCS) could provide information on cholesterol efflux. However, matrix effects interfere in liquid chromatography–mass spectrometry (LC-MS) analysis of NCS, thereby impairing the method sensitivity. The aims of this study were development, optimization and validation of LC-MS method for quantification of NCS in serum and HDL-NCS. Additionally, matrix effect interferences and methods application in individual serum samples were examined.

Methods
HDL precipitating reagent was used for HDL isolation. Matrix effect was examined by comparing different surrogates by simple regression analysis. Validation was conducted according to the FDA-ICH guideline. 20 healthy volunteers were recruited for testing of method application.

Results
The observed matrix effect was 30%, and matrix comparison showed that cholesterol was the dominant contributor to the matrix effect. Cholesterol concentration was adjusted by construction of the calibration curve for serum and HDL fraction (5 mmol/L and 2.5 mmol/L, respectively). The intra- and inter- run variabilities for NCSs were 4.7–10.3% for serum NCS and 3.6–13.6% for HDL-NCS and 4.6–9.5% for serum NCSs and 2.5–9.8% for HDL-NCS, respectively. Recovery studies showed satisfactory results for NCSs: 89.8–113.1% for serum NCS and 85.3–95.8% for HDL-NCS.

Conclusions
The method was successfully developed and optimized. The matrix interference was solved by customising calibration curves for each method and sample type. The measurement of NCS in HDL fraction was proposed for the first time as potentially useful procedure in biomedical researches.
Takotsubo Cardiomyopathy Precipitated By Thyroidectomy - A Case Report
Authors: Vujovic Katarina Savic , Stefanovic Branislav S. , Matic Dragan , Komnenovic Snezana , Toskovic Anka , Divac Nevena , Vuckovic Sonja , Prostran Milica 
Published: October 2019

Abstract
Takotsubo cardiomyopathy (TC) is an acute cardiac condition triggered by emotional or physical stress. General anesthesia and sympathetic activation are possible triggers for TC. However, little is known about the role of sympathovagal activity in TC. In our report, we present a female patient, aged 62, who underwent thyroidectomy and at the end of the surgery developed cardiac complications. The patient had no chest pain, but had ST depression and negative T waves on the electrocardiogram (ECG). Cardiospecific enzyme troponin was elevated. Cardiac catheterization revealed unobstructed coronary arteries. Echo-cardiography revealed the enlargement of the left ventricle and ejection fraction of 40%. The patient was diagnosed with TC and dual antiplatelet therapy was introduced, a beta blocker and ACE inhibitor.It is possible that TC in perioperative period after thyroidectomy in this patient occured due to both sympathetic and parasympathetic activation. Probably, extraction of large thyroid induced vagal stimulation which resulted in hypotension and bradicardia. The patient was subsequently treated with adrenaline and atropine. In this case, sympathetic and parasympathetic activation in different intervals could result in the development of this condition.
HUBUNGAN KEGUGURAN DAN ANEMIA DENGAN PERNIKAHAN USIA MUDA DI DESA HAPESONG LAMA
Authors: Suryaningsih Melfi , Asfriyati Asfriyati , Santosa Heru 
Published: October 2019

Pernikahan usia muda akan berlanjut dengan kehamilan usia muda. Akibat belum siapnya sistem reproduksi remaja untuk menerima kehamilan meningkatkan risiko untuk terjadinya komplikasi yang berpotensi meningkatkan angka kematian ibu dan bayi. Remaja dalam proses pertumbuhan dan perkembangan harus berbagi nutrisi dengan janin yang dikandungnya. Anemia kehamilan merupakan salah satu risiko yang akan dihadapi ibu hamil muda jika kebutuhan tubuh dan janinnya tidak tercukupi, selain itu keadaan psikologi remaja yang masih belum stabil dan siap dengan perubahan peran baru akan memicu terjadinya keguguran akibat stres. Tujuan penelitian adalah untuk memperoleh informasi hubungan pernikahan usia muda dengan keguguran dan anemia. Metode yang digunakan adalah Desain potong lintang, sampel 78 orang yang diambil secara simple random sampling. Pengambilan data dengan wawancara menggunakan kuesioner. Variabel terikat adalah pernikahan usia muda, variabel bebas adalah keguguran dan anemia. Analisis data dengan uji Chi Square. Hasil penelitian yaitu tidak terdapat hubungan menikah usia muda dengan keguguran tetapi terdapat hubungan yang bermakna antara pernikahan usia muda dengan anemia (p<0,05). Dapat disimpulkan bahwa ibu yang menikah muda berisiko mengalami anemia kehamilan dibandingkan dengan ibu yang menikah pada usia reproduksi sehat. Young marriages will continue with young pregnancies. As a result of not being ready for the adolescent reproductive system to accept pregnancy increases the risk for complications that could potentially increase maternal and infant mortality. Adolescents in the process of growth and development must share nutrients with the fetus they contain. Anemia of pregnancy is one of the risks faced by young pregnant women if the body and fetal needs are not fulfilled, besides the psychological state of adolescents who are still unstable and ready for a new role change will trigger a miscarriage due to stress. The purpose of this study was to obtain information on the relationship of young marriage with miscarriage and anemia. The method used is a cross-sectional design, a sample of 78 people taken by simple random sampling. Retrieval of data by interview using a questionnaire. The dependent variable is young marriage, the independent variable is miscarriage and anemia. Data analysis with Chi Square test. The results of the study are that there is no relationship between young marriage and miscarriage but there is a significant relationship between young marriage and anemia (p <0.05). It can be concluded that mothers who marry young are at risk of developing pregnancy anemia compared to mothers who marry at a healthy reproductive age.
KEAKTIFAN SISWA DARI ASPEK SIKAP DAN KETERAMPILAN MELALUI PEMBELAJARAN AKTIF
Authors: Halifah Iip Siti , Fajarianingtyas Dyah Ayu , Meita Nisfil Maghfiroh 
Published: October 2019

Pembelajaran aktif adalah pembelajaran yang dapat mengaktifkan siswa dalam mencari jawaban atas pertanyaan yang di berikan guru dan juga aktif dalam mencari solusi untuk masalah yang diberikan guru. Dalam pembelajaran aktif untuk mendapatkan keaktifansiswadariaspeksikap dan keterampilan terjadi melalui proses pencarian atau percobaan. Keaktifan siswa di MTs Aqidah Usymuni dari aspek sikap, dan aspek keterampilan rendah. Salah satu solusi yang dapat diterapkan yaitu pembelajaran akif. Penelitian ini bertujuan untuk mengetahui keaktifan siswa dari aspek sikap, dan aspek keterampilan setelah diterapkan pembelajaran aktif. Jenis penelitian ini merupakan Penelitian Tindakan Kelas (PTK). Subjek penelitian adalah siswa kelas VIII yang terdiri 16 siswaperempuan.Teknik pengumpulan data berupa lembar observasi. Data keaktifan siswa dari aspek sikap, aspek keterampilan dianalisis secara deskriptif dengan persentase. Hasil penelitian yang didapatkan yaitu (1) dan pada aspek sikap indikator bertanya termasuk kategori sangat tinggi, dan indikator berpendapat termasuk kategori tinggi; (2) serta pada aspek keterampilan indikator melakukan percobaan termasuk kategori sangat tinggi, indikator menjelaskan hasil percobaan termasuk kategori sangat tinggi, dan indikator merefleksi termasuk ketegori sangat tinggi. Pembelajaran Aktif dapat mengetahui keaktifan siswa dari aspek sikap, dan keterampilan.
Akılcı İlaç Kullanımının Boylamsal Bir Koridor Şeklinde Üç Yıllık Klinik Eğitim Programına Entegrasyonu
Authors: TERZİOĞLU BEBİTOĞLU Berna , GÜLPINAR Mehmet Ali 
Published: October 2019

Akılcı ilaç kullanımı ile ilgili ülkemizde ve dünyada çok sayıda eğitim faaliyeti yürütülmektedir. Ancak yapılan çalışmalarda günümüzde halen akılcı olmayan ilaç kullanımı olduğu, hekimlerin ve özellikle yeni mezun hekimlerin bu konuda yeterliğe sahip olmadığı ve öğrencilerin kendilerini reçete yazma konusunda yeterli hissetmediklerini bildirilmektedir. Bu nedenle mezuniyet öncesi eğitim döneminde başlayan ve ileri eğitim ve meslek yaşamları boyunca devam eden eğitimlerle akılcı ilaç kullanımının devamlılığının sürdürülmesi önemlidir. Öğrenen merkezli eğitim modellerinde öğrenenlerin kendi öğrenme süreçlerini yönettiği probleme dayalı öğrenme ve işbaşında öğrenme gibi aktif öğrenme yöntemleriyle rasyonel farmakoterapi eğitiminin yürütülmesi, öğrenmede kalıcılığın artırılması ve doktorların ilerideki klinik pratiklerinde kendi başlarına kaldıklarında rasyonel ilaç kullanımını değişen koşullara göre uygulayabilme yeterliğini kazanmaları için gereklidir. Klinik tedavi kılavuzları ve temel ilaç listeleri ile uyumlu rasyonel farmakoterapi eğitimi iyi reçeteleme alışkanlığı kazandırmak için yararlı olmaktadır. Öğrencilerin bilgi, beceri ve tutumları dikkate alarak, sıklıkla karşılaşılan klinik durumlar üzerinden yapılan probleme dayalı öğrenme ile işbaşında öğrenme etkinlikleri rasyonel ilaç kullanımı kazandırılması noktasında tercih edilebilecek etkili yöntemlerin başında gelmektedir. Yine, toplumda sık görülen hastalıklara yönelik rasyonel farmakoterapi eğitim modülleri ile, akılcı ilaç kullanımının tıp fakültelerinde klinik eğitim dönemlerinde tüm staj programlarına boylamsal bir koridor olarak entegre bir şekilde dahil edilmesi ile, öğrencilerin karşılaşacakları hastalıklarda reçete yazmada kendilerine güven duymalarına, kişisel ilaç formülerlerini hazırlayabilmelerine ve güvenli ve etkili tedavi planları oluşturabilmelerine olanak sağlayacaktır.
Profil Pemecahan Masalah Kreatif Siswa MA Ditinjau dari Tingkat Math Self-efficacy
Authors: Widodo Kukuh , Budiarto Mega Teguh , Lukito Agung 
Published: October 2019

Penelitian ini bertujuan mendeskripsikan profil pemecahan masalah kreatif siswa MA ditinjau dari tingkat math self-efficacy (MSE). Untuk mencapai tujuan peneliti menggunakan tahapan pemecahan masalah kreatif CPS Versi 6.1 yaitu membangun kesempatan, menggali data, membingkai masalah, membangkitkan ide, mengembangkan solusi, dan membangun penerimaan. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif. Subjek penelitian terdiri dari 2 siswa yaitu siswa dengan MSE tinggi dan rendah berdasarkan hasil analisis angket the PISA math self-efficacy scale. Teknik pengumpulan data adalah wawancara berbasis tugas untuk mendapatkan data mengenai pemecahan masalah kreatif siswa. Hasil penelitian menunjukkan bahwa (1) subjek dengan MSE tinggi malakukan tahapan membangun kesempatan, menggali data, membingkai masalah, membangkitkan ide (melakukan kefasihan, melakukan fleksibilitas, namun tidak melakukan kebaruan), mengembangkan solusi, dan membangun penerimaan; dan (2) subjek dengan MSE rendah melakukan tahapan membangun kesempatan, membingkai masalah, membangkitkan ide (melakukan kefasihan, melakukan fleksibilitas, namun tidak melakukan kebaruan), mengembangkan solusi, dan membangun penerimaan, namun tidak menggali data.
Pengembangan Penalaran Kuantitatif di Sekolah Dasar untuk Mengembangkan Berpikir Aljabar di Sekolah Menengah Pertama
Authors: Fu'adiah Dzikra 
Published: October 2019

Penalaran kuantitatif merupakan suatu penalaran yang menekankan pada penarikan kesimpulan berdasarkan data-data atau informasi kuantitatif. Sedangkan berpikir aljabar dikembangkan untuk melihat dan mempresentasikan pola dan hubungan yang direpresentasikan dalam ekspresi-ekpresi aljabar. Siswa belajar aljabar secara formal di kelas VII dan VIII. Pokok bahasan yang diberikan adalah bentuk aljabar dan sistem persamaan linier dua variabel. Kesulitan yang dialami oleh siswa adalah ketika menyelesaikan masalah kontekstual, terutama masalah yang kompleks. Sebagian besar siswa hanya menghafalkan algoritma atau metode dalam menyelesaikan masalah tanpa memahami dengan baik hubungan antara informasi-informasi yang diberikan dengan pertanyaan dalam masalah. Solusi dari masalah tersebut adalah menggunakan pendekatan pengembangan penalaran kuantitatif yang dimunculkan dalam proses pembelajaran matematika dari jenjang pendidikan dasar. Solusi tersebut dapat dilakukan karena terdapat hubungan timbal balik antara pengembangan jangka panjang kemampuan aljabar siswa dengan pengembangan jangka panjang penalaran kuantitatif siswa. Langkah selanjutnya adalah mengembangkan kegiatan pembelajaran matematika di SD yang berfokus pada mengembangkan penalaran kuantitatif siswa, karena penalaran kuantitatif dapat dikembangkan mulai dari seseorang berumur lima tahun, sehingga dapat dimulai dari siswa mengenal bilangan.
Keterampilan Berpikir Kreatif Mahasiswa Calon Guru Matematika dalam Pemecahan Masalah Kontekstual
Authors: Santia Ika 
Published: October 2019

Abstrak.Keterampilan berpikir kreatif sangat penting dimiliki calon guru matematika dalam menghadapi kompetisi era global karena tingkat kompleksitas masalah yang semakin meningkat. Oleh karena melihat pentingnya keterampilan berpikir kreatif mahasiswa calon guru matematika, maka penelitian ini bertujuan:1) Mendeskripsikan bagaimana keterampilan berpikir kreatif mahasiswa calon guru matematika; 2) Menganalisis proses pemecahan masalah kontekstual oleh mahasiswa calon guru matematika yang didasarkan keterampilan berpikir kreatif. Penelitian ini adalah penelitian kualitatif bersifat eksploratif yang dilaksanakan dalam kelas MKPBM IV di UN PGRI Kediri pada bulan Januari 2016 menggunakan metode tes dan wawancara. Selanjutnya untuk menguji kredibilitas data dilakukan triangulasi waktu. Hasil penelitian menunjukkan bahwa:1) Terdapat 5 mahasiswa dari 36 mahasiswa yang memenuhi 4 indikator berpikir kreatif, yaitu kelancaran (fluency), fleksibilitas (flexibility), elaborasi(elaboration) dan keaslian (originality). Dari kelima mahasiswa tersebut terdapat 2 mahasiswa yang memiliki fluency tertinggi(SCT), 1 mahasiswa memiliki flexibility tertinggi (SFT), 1 mahasiswa memiliki originality tertinggi (SOT) dan 1 mahasiswa memiliki elaborasi tertinggi (SET); 2) Dalam pemecahan masalah kontekstual, SCT dan SFT menggunakan cara eliminasi-substitusi model matematika dan termasuk dalam TKBK3, SET menggunakan representasi skematik dan cara trial-error, sedangkan SOT menggunakan representasi figural. SET dan SOT termasuk dalam TKBK 4. Abstract.Skill of think creatively is very important owned by mathematics preservice teacher to thrive in global era competition because complexities of problem is progressively expanded. Based of the important of creatively skill used mathematics preservice teacher in learns mathematics, hence this research’s aimed to: 1) Describe how mathematics preservice teacher’s creativity skill of when learning mathematics 2) Analize process solving contextual problem by mathematics preservice teacher based their mathematics creativety skill. This is qualitative research because have explorative character which these research placed in class of MKPBM IV UN PGRI Kediri on January 2016 with written test method and interview method. To ensure the validity of data, this research used time triangulation. Result of research showed: 1) There are 5 student from 36 student fulfilling 4 indicator of creatively thingking
A importância da utilização ferramentas do moodle na educação a distância
Authors: Souza Ana Paula Lopes de 
Published: October 2019

Esta pesquisa é de natureza qualitativa, onde aborda alguns levantamentos bibliográficos e documentais sobre teóricos e discussões referente a temática. Buscou-se destacar a importância da utilização das ferramentas Moodle na Educação a Distância, além de analisar as potencialidades das referidas ferramentas na construção da aprendizagem nos Ambientes Virtuais de Aprendizagem (AVA). Os resultados obtidos basearam-se nas seguintes categorias de análise: contribuições da Educação a Distância (EAD) e as potencialidades das ferramentas do Moodle na aprendizagem. Conclui-se que as ferramentas virtuais disponibilizadas nos AVA garantem auxilio e interatividade ao ensino e potencializam a aprendizagem na EAD quando utilizadas de forma adequada.
Apresentação do dossiê Educação e pesquisa online
Authors: Lucena Simone 
Published: October 2019

Este dossiê apresenta algumas reflexões sobre as transformações que o desenvolvimento das tecnologias da informação e comunicação (TIC) trouxe para a sociedade contemporânea em diferentes áreas do conhecimento entre elas a educação. Estas transformações, iniciadas desde a última década do século XX, ganharam maior amplitude no atual século XXI principalmente a partir da utilização das tecnologias móveis que operam por meio de conexões com redes do tipo wi-fi, 3G ou 4G. Para continuar lendo acesse o pdf
A formação continuada de professores da educação infantil no município de Ouvidor (GO)
Authors: Silva Altina Abadia da , Martin Avelina Oliveira de Sousa , Goveia Eliane Gomes de , Silveira Mikaelli Carín Tavares 
Published: October 2019

Resumo: Este artigo originou-se de uma pesquisa cujo objetivo foi analisar a formação continuada de professores da Educação Infantil do Município de Ouvidor (GO) procurando entender como são constituídos os espaços formativos desses professores e quais os impactos dessa formação, na sua prática pedagógica. O Referencial Teórico adotado é a Psicologia Histórico-Cultural, com ênfase no conceito vygotskyano de mediação por ser ele central na teoria de Vygotsky e por entendermos a mediação pedagógica como condição maior do trabalho docente. Essa opção está relacionada também com o fato de trabalharmos com a formação inicial de professores e por desenvolvermos projetos de extensão com docentes deste município. Através de observações realizadas nos encontros de planejamento de professores da pré-escola, nas reuniões coletivas quinzenais realizadas pela secretaria de educação e pelas entrevistas com um grupo de professores e gestores realizamos a investigação de como ocorriam, até o ano de 2015 a formação continuada dos professores da Educação Infantil. Encontramos indicativos da ineficiência da formação continuada recebida, por se pautar na racionalidade técnica e na imitação de um professor modelo que transmitia a seus pares, atividades e concepções de acordo com sua interpretação e compreensão, impossibilitando que os professores refletissem de maneira crítica e autônoma sua prática pedagógica.Palavras-chave: Educação infantil. Formação de professores. Processos formativos.