bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heterogeneous catalysis for thioanisole oxidation using hydrogen peroxide and Copper, Nickel and Zinc tungstates prepared by the polymeric precursor method
Authors: Lima Naiara Arantes , Alencar Lorena Dariane da Silva , Mendonça Gabryella Cerri , Mesquita Alexandre , Silva Augusto Vieira Pontes , Rosmaninho Marcelo Gonçalves , Taylor Jason Guy , Fajardo Humberto Vieira , Moraes Leonardo César , Bernardi Maria Inês Basso 
Published: April 2020

Abstract
The oxidation of sulfides to sulfoxides and sulfones provides valuable sulfur-containing chemical compounds that are used in the pharmaceutical agrochemical industry. Although some tungsten catalytic systems have been applied to sulfide oxidation, the most desirable heterogeneous catalytic protocols have not been described. The copper, nickel and zinc tungstates powders obtained by the polymeric precursor method and the evaluation of their catalytic activity in thioanisole oxidation were investigated. Thioanisole was oxidized by hydrogen peroxide to sulfoxides and sulfones and the presence of catalyst accelerates the conversion. Of the three catalysts, copper tungstate was the most efficient in the conversion process followed by nickel tungstate and finally zinc tungstate. The copper tungstate has higher hydrogen consumption, indicating a higher oxygen content on the surface and the ability to increase surface mobility, which increases the conversion and selectivity of the process. The addition of 0.1 mL of hydrogen peroxide enhanced the conversion and increased the amount of sulfone produced. The ideal reaction time was 12 hours and the optimum temperature was 75 °C.
A novel strategy for efficient disaccharides synthesis from glucose by β-glucosidase
Authors: Niu Kangle , Liu Zhengyao , Feng Yuhui , Gao Tianlong , Wang Zhenzhen , Zhang Piaopiao , Du Zhiqiang , Gao Daming , Fang Xu 
Published: April 2020

Abstract
Oligosaccharides have important therapeutic applications. A useful route for oligosaccharides synthesis is reverse hydrolysis by β-glucosidase. However, the low conversion efficiency of disaccharides from monosaccharides limits its large-scale production because the equilibrium is biased in the direction of hydrolysis. Based on the analysis of the docking results, we hypothesized that the hydropathy index of key amino acid residues in the catalytic site is closely related with disaccharide synthesis and more hydrophilic residues located in the catalytic site would enhance reverse hydrolysis activity. In this study, positive variants TrCel1bI177S, TrCel1bI177S/I174S, and TrCel1bI177S/I174S/W173H, and one negative variant TrCel1bN240I were designed according to the Hydropathy Index For Enzyme Activity (HIFEA) strategy. The reverse hydrolysis with TrCel1bI177S/I174S/W173H was accelerated and then the maximum total production (195.8 mg/ml/mg enzyme) of the synthesized disaccharides was increased 3.5-fold compared to that of wildtype. On the contrary, TrCel1bN240I lost reverse hydrolysis activity. The results demonstrate that the average hydropathy index of the key amino acid residues in the catalytic site of TrCel1b is an important factor for the synthesis of laminaribiose, sophorose, and cellobiose. The HIFEA strategy provides a new perspective for the rational design of β-glucosidases used for the synthesis of oligosaccharides.
Desquamation In Kawasaki Disease And Its Relationship With Coronary Artery Abnormalities
Authors: YAN JIAHUEI , Lo Wan-Shan , Guo Mindy Ming-Huey , Huang Ying-Hsien , Chang Ling-Sai , Kuo Ho-Chang 
Published: April 2020

Abstract
Background Desquamation of hands and feet is a common characteristic of Kawasaki disease (KD), and occurs in 68-98% of patients diagnosed with KD. In this study, we analyzed patients’ varying desquamation levels in their hands or feet, in correlation with clinical presentation, to assess the relationship.Method We retrospectively reviewed children with KD who had follow-up visits in Kaohsiung Chang Gung Memorial Hospital’s pediatric outpatient department (OPD) during 2018 and 2019. We analyzed their age, laboratory data before intravenous immunoglobulin (IVIG) treatment, and coronary artery abnormalities (CAA) based on the desquamation level of their hands and feet.Results We enrolled a total 112 patients in the study, and 92 patients (82.1%) had hand or feet desquamation. We found the hands’ high-grade desquamation was positively associated with age and segmented neutrophil percentage (p=0.047 and 0.029, respectively) but negatively associated with lymphocyte and monocyte percentage (p=0.03 and 0.006, respectively). Meanwhile, the feet’s high-grade desquamation was positively associated with total white blood cell count (p=0.033). Furthermore, we found that high-grade hand desquamation had less probability of CAA formation compared with that of a low grade (7.1% vs. 40.8%, p=0.016). We observed no significant difference in IVIG resistance between the groups. Conclusion This report is the first to demonstrate that the desquamation level of hands or feet in Kawasaki disease is associated with different coronary artery abnormalities and laboratory findings. Physicians should be cautious of CAA formation, particularly in patients with low-grade hand peeling.
Associations of Participation in Organized Sports and Physical Activity in Preschool Children: A Cross-Sectional Study
Authors: Chen Chu , Sellberg Fanny , Ahlqvist Viktor H. , Neovius Martin , Christiansen Filip , Berglind Daniel 
Published: April 2020

Abstract
Background Participation in organized sports is associated with higher physical activity (PA) levels in school-aged-children. Yet, little is known about PA determinants in preschool-aged-children. We examined associations between organized sports participation and preschoolers’ daily PA.Methods The study comprised 290 3–5 years old children and PA was measured for 1 week via accelerometers. Organized sports participation was parent-reported and preschool time was teacher-recorded. Linear mixed models, nested on preschool level, were used to examine associations between organized sports participation and children’s PA outside preschool time, during preschool time and throughout the day.Results In total, 146 children (50.3%) participated in organized sports at least 1 hour/week. Participation in organized sports was associated with 6.0 more minutes of moderate-to-vigorous PA (MVPA) (95% CI: 0.6, 11.3) throughout the day and 5.7 more minutes of MVPA (95% CI: 1.6, 9.7) outside preschool time after adjustment. There was no association between organized sports participation and PA during preschool time.Conclusions This is the first study to show positive associations between organized sports participation and preschoolers’ PA levels outside preschool time and throughout the day. In addition, findings from this study do not support PA compensation. Therefore, targeting organized sports may be successful in improving PA, even among preschoolers.
Customer satisfaction in the digital era: evidence from Islamic banking
Authors: zouari Ghazi , Abdelhedi Marwa 
Published: April 2020

Abstract
PurposeBased upon an extended SERVQUAL model, this paper attempts to contribute to the Islamic banking literature by examining the impact of digitalization, as a service quality dimension, on customer satisfaction.Design/methodology/approachTwo dimensions, i.e. digitalization and compliance are added to the existing SERVQUAL model of five dimensions. Results are drawn from a self-completed survey of a convenience sample of 145 Tunisian Islamic bank customers for the year 2018. Factor analysis and regression analysis are used to determine factor structure and determine the impact of service quality dimensions, especially digitalization, on customer satisfaction in Islamic banking.FindingsThe factor analysis extracted five dimensions of service quality, i.e. confidence, compliance, digitalization, tangibles and human skills. The paper demonstrates a positive and significant relationship between the main dimensions of customer service quality and customer satisfaction, except for tangibles.Research limitations/implicationsAlthough the outcomes lend support to the extended SERVQUAL model, the results are derived based on a relatively small sample size in one country (Tunisia). This limits the generalizability of the study results. It might also be useful to enlarge the study sample and include a comparison between Islamic versus conventional banking about service quality and customer satisfaction.Managerial implications:To remain competitive, Tunisian Islamic banks need to pay attention to the way the services are delivered and not take it for granted that customers are only focusing on compliance. Dealing henceforth with Generation Y customers, they must persevere in bringing their customer service into the digital era.Originality/valueThis study is one of few which try to investigate the drivers of customer satisfaction for Islamic banks in a Digital Era. It reveals that although customers pay special attention to Sharia’ laws, the way services are delivered matters to them too. From now on, digital banking must appear among the Islamic bank features to stay relevant in the Digital Era.
Circ_0084927 promotes cervical carcinogenesis by sponging miR-1179 that suppresses CDK2, a cell cycle-related gene
Authors: Qu Xinhua , Zhu Liumei , Song Linlin , Liu Shaohua 
Published: April 2020

Abstract
Background: Cervical cancer (CC) is a highly malignant tumor. Evolving researches on CC have unveiled a concept that circRNA exerts important roles in CC progression. In this study, we mainly explored the role of a novel circRNA, circ_0084927, and its regulatory network in the development of CC.Methods: qRT-PCR was applied to evaluate the expression of circ_0084927, miR-1179 and CDK2 mRNA in CC tissues and cells. Dual-luciferase reporting experiments and RNA immunoprecipitation (RIP) assay were conducted to validate the target relationship of miR-1179 with circ_0084927 and CDK2 mRNA. CCK-8 and BrdU assay was used to evaluate CC cell proliferation. The adhesion and apoptosis phenotypes of CC cells were measured by cell-matrix adhesion and caspase 3 activation assay. Flow cytometry was employed to detect CC cell cycle.Results: Our results indicated that circ_0084927 was up-regulated in CC tissues and cells, and circ_0084927 silence inhibited CC cell proliferation and adhesion, while facilitating apoptosis as well as triggering cell cycle arrest. On the other hand, miR-1179 down-regulation appeared in CC tissues. Additionally, circ_0084927 abolished miR-1179’s inhibitory effects on cell proliferation and adhesion. Our study showed that CDK2 was up-regulated in CC tissues and played a cancer-promoting role. Furthermore, miR-1179 directly targeted CDK2, thereby inhibiting CDK2’s promotion on the malignant phenotypes of CC cells. circ_0084927 revoked the inhibitory effect of miR-1179 on CDK2 by sponging miR-1179.Conclusion: Circ_0084927 promoted cervical carcinogenesis by sequestering miR-1179 that directly targeted CDK2. Our results shed light on the circ_0084927/miR-1179/CDK2 regulatory network that strengthened CC aggressiveness, providing novel candidate targets for CC treatment.
Factors Associated with Duration of Breastfeeding in Bangladesh: Evidence from Bangladesh Demographic and Health Survey 2014
Authors: Ayesha Ummay , Mamun ASMA , Sayem Md. Abu , Hossain Golam 
Published: April 2020

Abstract
Background: Breastfeeding is one of the most effective ways for reducing infant mortality and confirming optimal growth and development of children. The aim of this study was to find the effect of socio-demo­graphic determinants on duration of breast­feeding among Bangladeshi mothers.Methods: The data was extracted from the Bangladesh Demographic and Health Survey (BDHS)-2014. A total of 3541 married non–pregnant Bangladeshi mothers in reproductive age who had at least one child aged 6-36 months were included. Independent sample t-test and ANOVA were used to find the significance deference in duration of breastfeeding between two and more than two groups respectively. Multiple linear regression model was utilized to determine the effect of some quantitative variables on duration of breastfeeding among Bangladeshi mothers. Results: This study raveled that the mean duration of breastfeeding among Bangladeshi mothers was 18.91±7.98 (95% CI: 18.65-19.17) and median was 19.00 month. Independent sample t-test provided that short duration of breastfeeding was observed among; (i) mothers received antenatal care facilities during their pregnancy period, (ii) Muslim and (iii) delivered their last child by caesarean section. ANOVA showed that duration of breastfeeding significantly influenced by (i) parents’ education, (ii) geographical location and (iii) household wealth quintile. Multiple regression analysis demonstrated that mothers’ age, mothers’ body mass index, total number of children and mothers’ mothers’ age at first birth were important predictors of duration of breastfeeding.Conclusion: Health care providers and decision makers can consider these findings to make plan for counseling of mothers and family members to promote optimal duration of breastfeeding practice in first three years of baby’s life.
MISIRoot: A Robotic Minimum Invasion in Situ Imaging System for Plant Root Phenotyping
Authors: Song Zhihang , Qiu Wei , Jin Jian 
Published: April 2020

Abstract
Background: Plant root phenotyping technologies play an important role in breeding, plant protection, and other plant science research projects. The root phenotyping customers urgently need technologies that are low-cost, in situ, non-destructive to the roots, and suitable for the natural soil environment. Many recently developed root phenotyping methods such as minirhizotron, X-CT, and MRI scanners have their unique advantages in observing plant roots, but they also have disadvantages and cannot meet all the critical requirements simultaneously. Results: The study in this paper focuses on the development of a new plant root phenotyping robot that is minimally invasive to plants and working in situ inside natural soil, called “MISIRoot”. The MISIRoot system mainly consists of an industrial-level robotic arm, a mini-size camera with lighting set, a plant pot holding platform, and the image processing software for root recognition and feature extraction. MISIRoot can take high-resolution color images of the roots in soil with minimal disturbance to the root and reconstruct the plant roots’ three-dimensional (3D) structure at an accuracy of 0.1 mm. In a test assay, well-watered and drought-stressed groups of corn plants were measured by MISIRoot at V3, V4, and V5 stages. The system successfully acquired the RGB color images of the roots and extracted the 3D points cloud data containing the locations of the detected roots. The plants measured by MISIRoot and plants not measured (control) were carefully compared with the results from the Hyperspectral Imaging Facility (reference). No significant differences were found between the two groups of plants at different growth stages. Conclusion: The MISIRoot system recently developed at Purdue University has been proved effective in root phenotyping with multiple advantages: With a comparatively low cost and minimal invasion to the plant, this system can automatically measure the root’s 3D structure and take color images of the roots in ordinary soil media, and in situ. This system provides a new option for root phenotyping researchers and has a potential to be applied in a wide range of research topics such as breeding, plant protection and so on.
The injury mechanism spectra and injury pyramids among children and adolescents in Zhuhai City, China
Authors: Yin Xiling , Dai Wencan , Du Yukai , Li Deyun 
Published: April 2020

Abstract
Background: The unclear spectra and severity of injuries in the injury pyramids for Chinese children and adolescents prevent the prioritization interventions. This study aimed to describe the injury mechanism spectra and injury pyramids in this population to provide a priority for injury prevention strategies.Methods: Death, hospitalization, and outpatient/emergency department visit data from patients aged 0~17 years with injuries were obtained from January 1, 2013, to December 31, 2017, in Zhuhai City, China. The injury mechanism ratios were calculated, and the injury pyramids were drawn in proportion by using injury mortality and the incidence of both injury hospitalizations and outpatient/emergency department injury visits.Results: The top three mechanisms for injuries in children and adolescents seen in outpatient/emergency departments were falls (52.02%), animal bites (14.57%), and blunt injuries (10.60%). The top three mechanisms for injury hospitalizations were falls (37.33%), road traffic injuries (17.87%), and fire/burns (14.29%), while the top three mechanisms for injury deaths were drowning (32.91%), road traffic injuries (20.25%) and falls (13.92%). The incidence rate of outpatient/emergency department injury visits for children and adolescents was 11210.87/100,000; the incidence rate of injury hospitalization was 627.09/100,000, and the injury death rate was 10.70/100,000. For each injury death, there were 59 injury hospitalizations and 1,047 outpatient/emergency injury visits.Conclusions: The injury spectra were different for injury-related outpatient/emergency department visits, hospitalizations, and deaths among children and adolescents. The different sexes had different injury spectra at different stages of child development, and interventions should be formulated based on this finding. The size and shape of the injury pyramids varied by age, sex, region, and injury mechanisms; minor nonfatal injuries were more common in children and adolescents. The differences in the severity and extent of the injuries suggested that injury interventions in Chinese children and adolescents still have a long way to go.
A cross sectional study on contraceptive knowledge, attitude and practice among teenage girls in secondary schools in Wanging’ombe district - Njombe Region.
Authors: Mbilinyi (MPH) Luwoneko B. , Moshiro Candida 
Published: April 2020

Abstract
Background: Low contraceptive knowledge and practice among sexually active teenage girls in secondary schools remain a significant issue in Tanzania. This accelerates the problem of teenage pregnancy which takes a heavy toll on teenage girls’ health and education well-being. Assessing the knowledge, attitude, and practice of contraceptive methods among teenage girls in secondary schools is of crucial importance in order to alleviate the problem.Methods: A cross sectional survey was done involving 600 school girls. A questionnaire was used to gather information on demographic characteristics, knowledge on contraceptive methods, use, access, attitude and knowledge on the consequences of teenage pregnancy. Descriptive statistics were used to summarize demographic characteristics. Multivariate logistic regression analysis was used to analyze factors associated with knowledge on contraceptive methods while controlling for potential confounders. Odds ratios and 95% confidence intervals were computed.Results: Sixty percent had knowledge on at least one contraceptive method. Among sexually active teenagers, fifteen percent reported to have ever used any form of contraceptive and ten percent were currently using contraceptives. Factors that were significantly associated with knowledge on any contraceptive methods were older age, higher class level, Muslim religion, urban residence, type of school, public school and middle-income economic condition. while teenage attitude towards contraceptives was positive (99.7%). About two thirds of the girls had knowledge on the consequences of teenage pregnancy.Conclusion: This article reveals that knowledge and use of contraceptive methods is still unsatisfactory and knowledge on the consequences of teenage pregnancy is unsatisfactory. The government and other stakeholders need to come up with effective interventions to alleviate the problem.Keywords: Knowledge, Access, Attitudes, Contraceptive methods, Teenage pregnancy.
Child undernutrition in households with microbiologically safer drinking water and ‘improved water’ in Tanna, Vanuatu
Authors: Morrison Alexandra L. , Lewthwaite Hanneke , Houghton Lisa A. , Nasak Daniel Sum Jimmy , Sharples Katrina J. , Brown Peter , Crump John A. , Jack Susan J. 
Published: April 2020

Abstract
The Sustainable Development Goal drinking water indicators include microbiological safety measures, whereas the Millennium Development Goal indicator ‘improved water’ may be microbiologically unsafe. In rural Vanuatu, we undertook household surveys, child anthropometry, and tested stored drinking water, to investigate relationships between water and undernutrition. Using Escherichia coli most probable number, we categorized results according to Compartment Bag Test drinking water cutoffs: &lt;1/100 mL (safe), 1–10/100 mL (intermediate risk), &gt;10–100/100 mL (high risk), and &gt;100/100 mL (very high risk). Of 201 households, 191 (95%) had microbiologically unsafe drinking water, regardless of ‘improved’ status. We investigated cross-sectional associations between households with microbiologically safer drinking water (≤10 E. coli/100 mL) versus ‘improved water’ and undernutrition among children. Of children under 5, 145 (48.8%, 95% CI: 42.8, 54.8) were stunted and 59 (19.1%, 95% CI: 14.4, 23.8) were underweight. Among households with ‘improved water’, the adjusted prevalence ratio (95% CI) of stunting was 0.61 (0.46, 0.80) and underweight was 0.46 (0.29, 0.73) compared with ‘unimproved water’. However, we found no association between having drinking water with ≤10 E. coli/100 mL at one point in time and undernutrition. Longer-term variations in water quality and unmeasured conditions beyond water may have contributed to these associations.
Robust Transcription Factor Binding Site Prediction Using Deep Neural Networks
Authors: Geete Kanu , Pandey Manish 
Published: April 2020

Aims:
Robust and more accurate method for identifying transcription factor binding sites
(TFBS) for gene expression.

Background:
Deep neural networks (DNNs) have shown promising growth in solving complex
machine learning problems. Conventional techniques are comfortably replaced by DNNs in
computer vision, signal processing, healthcare, and genomics. Understanding DNA sequences is
always a crucial task in healthcare and regulatory genomics. For DNA motif prediction, choosing the
right dataset with a sufficient number of input sequences is crucial in order to design an effective
model.

Objective:
Designing a new algorithm which works on different dataset while an improved
performance for TFBS prediction.

Methods:
With the help of Layerwise Relevance Propagation, the proposed algorithm identifies the
invariant features with adaptive noise patterns.

Results:
The performance is compared by calculating various metrics on standard as well as recent
methods and significant improvement is noted.

Conclusion:
By identifying the invariant and robust features in the DNA sequences, the
classification performance can be increased.