bluuebunny/crossref_metadata_2025_split huggingface dataset:
The separation of softwood and hardwood in historical wooden statues of the Nazenji-temple in Japan using NIR spectroscopy
Authors: Abe Hisashi , Kurata Yohei , Watanabe Ken , Ishikawa Atsuko , Noshiro Shuichi , Fujii Tomoyuki , Iwasa Mitsuharu , Kaneko Hiroaki , Wada Hiroshi 
Published: September 2020

Abstract
The applicability of near-infrared (NIR) spectroscopy to the identification of wood species of archaeologically/historically valuable wooden artifacts in a non-invasive manner was investigated using reference wood samples from the xylarium of the Forestry and Forest Products Research Institute (TWTw) and applied to several wooden statues carved about 1000 years ago. Diffuse-reflectance NIR spectra were obtained from five standard wood samples each of five softwood species (Chamaecyparis obtusa, Cryptomeria japonica, Sciadopitys verticillata, Thujopsis dolabrata, Torreya nucifera) and five hardwood species (Aesculus turbinata, Cercidiphyllum japonicum, Cinnamomum camphora, Prunus jamasakura, Zelkova serrata). A principal component analysis (PCA) model was developed from the second derivative spectra. The score plot of the first two components clearly showed separation of the wood sample data into softwood and hardwood clusters. The developed PCA model was applied to 370 spectra collected from 21 wooden statues preserved in the Nazenji-temple in Shizuoka Prefecture in Japan, including 14 made from Torreya spp. and 7 made from Cinnamomum spp. In the score plot, the statue spectra were also divided into two clusters, corresponding to either softwood (Torreya spp.) or hardwood (Cinnnamomum spp.) species. These results show that NIR spectroscopy combined with PCA is a powerful technique for determining whether archaeologically/historically valuable wooden artifacts are made of softwood or hardwood.
Performance verification of anti-SARS-CoV-2-specific antibody detection by using four chemiluminescence immunoassay systems
Authors: Wan Yafang , Li Zhijie , Wang Kun , Li Tian , Liao Pu 
Published: September 2020

Objectives The purpose of the current study was to evaluate the analytical performance of seven kits for detecting IgM/IgG antibodies against coronavirus (SARS-CoV-2) by using four chemiluminescence immunoassay systems. Methods Fifty patients diagnosed with SARS-CoV-2 infection and 130 controls without coronavirus infection from the General Hospital of Chongqing were enrolled in the current retrospective study. Four chemiluminescence immunoassay systems, including seven IgM/IgG antibody detection kits for SARS-CoV-2 (A_IgM, A_IgG, B_IgM, B_IgG, C_IgM, C_IgG and D_Ab), were employed to detect antibody concentrations. The chi-square test, the receiver operating characteristic (ROC) curve and Youden’s index were determined to verify the cut-off value of each detection system. Results The repeatability verification results of the A, B, C and D systems are all qualified. D_Ab performed best (92% sensitivity and 99.23% specificity), and B_IgM performed worse than the other systems. Except for the A_IgM and C_IgG systems, the optimal diagnostic thresholds and cut-off values of the other kits and their recommendations are inconsistent with each other. B_IgM had the worst AUC, and C_IgG had the best diagnostic accuracy. More importantly, the B_IgG system had the highest false-positive rate for testing patients with AIDS, tumours and pregnancies. The A_IgM system test showed the highest false-positive rates among elderly individuals over 90 years old. COVID-2019 IgM/IgG antibody test systems exhibit performance differences. Conclusions The Innodx Biotech Total Antibody serum diagnosis kit is the most reliable detection system for anti-SARS-CoV-2 antibodies, which can be used together with nucleic acid tests as an alternative method for SARS-CoV-2 detecting.
Facial Nerve Outcomes After Vestibular Schwannoma Microsurgical Resection in Neurofibromatosis Type 2
Authors: Sobieski Catherine , Killeen Daniel E. , Barnett Samuel L. , Mickey Bruce E. , Hunter Jacob B. , Isaacson Brandon , Kutz Joe Walter 
Published: September 2020

ObjectiveThe aim of this study is to investigate facial nerve outcomes after microsurgical resection in neurofibromatosis type 2 (NF2) compared to sporadic tumors.Study DesignSingle institutional retrospective chart review.SettingTertiary referral center.MethodsAll adult patients with NF2 vestibular schwannoma (VS) or sporadic VS who underwent microsurgical resection from 2008 to 2019 with preoperative magnetic resonance imaging (MRI) and 1 year of postsurgical follow‐up were included. The primary outcome measure was postoperative House‐Brackmann (HB) facial nerve score measured at first postoperative visit and after at least 10 months.ResultsIn total, 161 sporadic VSs and 14 NF2 VSs met inclusion criteria. Both median tumor diameter (NF2, 33.5 mm vs sporadic, 24 mm, P =. 0011) and median tumor volume (NF2, 12.4 cm3 vs sporadic, 2.9 cm3, P =. 0005) were significantly greater in patients with NF2. The median follow‐up was 24.9 months (range, 12‐130.1). Median facial nerve function after 1 year for patients with NF2 was HB 3 (range, 1‐6) compared to HB 1 (range, 1‐6) for sporadic VS (P =. 001). With multivariate logistic regression, NF2 tumors (odds ratio [OR] = 13.9, P =. 001) and tumor volume ≥3 cm3 (OR = 3.6, P =. 025) were significantly associated with HB ≥3 when controlling for age, sex, extent of tumor resection, translabyrinthine approach, and prior radiation.ConclusionTumor volume >3 cm3 and NF2 tumors are associated with poorer facial nerve outcomes 1 year following microsurgical resection.
Alternating Unilateral Versus Bilateral Injections of Botulinum Toxin for the Treatment of Adductor Spasmodic Dysphonia
Authors: Lee Seung Jin , Kang Min Seok , Choi Hong‐Shik , Lim Jae‐Yol 
Published: September 2020

ObjectiveThis study aimed to compare the long‐term efficacy, durability, and dose and interval stability between alternating unilateral and bilateral injections of botulinum neurotoxin type A for the treatment of adductor spasmodic dysphonia.Study DesignRetrospective cohort study.SettingAcademic tertiary medical center.MethodsA total of 137 patients (105 alternating unilateral and 32 bilateral injections) who were administered ≥5 injections of botulinum neurotoxin type A were included in this study. The mean dosage change, dose adjustment ratio (number of dose increases/total number of injections), and stability of treatment responses were compared between the alternating unilateral and bilateral injection groups.ResultsLong‐term changes in the mean dosages for alternating unilateral (mean ± SD, –0.010 ± 0.048 IU) and bilateral (–0.042 ± 0.142 IU) injections did not differ between groups (P=. 225), suggesting that both methods follow a decreasing dosing trend over time. The dose adjustment ratio also did not differ between groups (P=. 077), although a longer average treatment interval (P<. 001) and duration of hoarse voice (P=. 045) were found in the bilateral injection group. The proportion of stable patients who did not increase injection dose and had regular follow‐up did not differ between the groups.ConclusionBoth alternating unilateral and bilateral injection methods showed a long‐term decreasing dosing trend, with comparable levels of efficacy, durability, and stability for treating adductor spasmodic dysphonia. Our findings indicate that alternating unilateral injections can be routinely performed with fewer side effects, albeit at shorter treatment intervals, than bilateral injections.
Opioid Prescribing in Patients Undergoing Neck Dissections With Short Hospitalizations
Authors: Banik Grace L. , Kraimer Kristen L. , Shindo Maisie L. 
Published: September 2020

ObjectiveTo evaluate postoperative opioid prescribing in patients undergoing neck dissections with short hospitalizations.Study DesignRetrospective cohort study.SettingTertiary academic hospital.MethodsThe study population included patients who underwent lateral neck dissections with or without an associated head and neck procedure and required hospitalization for ≤3 days from 2012 to 2019. Interventions to decrease opioid utilization, including preoperative counseling, multimodality pain management, and multidisciplinary collaboration, were implemented in September 2016. Patients were divided into 2 groups: preintervention (group 1) and postintervention (group 2). The mean quantity of opioids prescribed during hospitalization, at discharge, and in refills was calculated in morphine milligram equivalents (MME).ResultsA total of 407 patients were included in the analysis: 223 patients in group 1 and 184 patients in group 2 (42.3% female, 89.4% white; average age, 55.2 years [95% CI, 53.6‐56.9]). The mean opioid quantity prescribed in unilateral neck dissection alone decreased from 353.9 MME (95% CI, 266.7‐441.2) in group 1 to 113.3 MME (95% CI, 87.8‐138.7) in group 2 (P <. 001; effect size, 1.0). Statistically significant decreases in mean opioid quantity prescribed were also observed in unilateral neck dissection in combination with thyroidectomy, parotidectomy, glossectomy, or tonsillectomy. The percentage of patients requiring opioid prescription refills was not statistically different between the groups.ConclusionThis study demonstrates that the quantity of opioids prescribed in patients undergoing neck dissections and associated head and neck procedures with short hospitalizations can be reduced to as low as 100 to 125 MME with preoperative counseling, multimodality pain management, and multidisciplinary collaboration.
Utility of material-specific fat images derived from rapid-kVp-switch dual-energy renal mass CT for diagnosis of renal angiomyolipoma
Authors: Walker Daniel , Udare Amar , Chatelain Robert , McInnes Matthew , Flood Trevor , Schieda Nicola 
Published: September 2020

Background Renal angiomyolipoma (AML) are benign masses that require detection of macroscopic fat for accurate diagnosis. Purpose To evaluate fat material-specific images derived from dual-energy computed tomography (DECT) to diagnose renal AML. Material and Methods This retrospective case-control study evaluated 25 renal AML and 44 solid renal masses (41 renal cell carcinomas, three other tumors) imaged with rapid-kVp-switch DECT (120 kVp non-contrast-enhanced [NECT], 70-keV corticomedullary [CM], and 120-kVp nephrographic [NG]-phase CECT) during 2017–2018. A radiologist measured attenuation (Hounsfield Units [HU]) on NECT, CM-CECT, NG-CECT, and fat concentration (mg/mL) using fat-water base-pair images. Results At NECT, 100% (44/44) non-AML and 4.0% (1/25) AML measured >–15 HU. At CM-CECT and NG-CECT, 24.0% (6/25) and 20.0% (5/25) AML measured >–15 HU (size 6–20 mm). To diagnose AML, area under receiver operating characteristic curve (AUC) using –15 HU was: 0.98 (95% confidence interval [CI] 0.98–1.00) NECT, 0.88 (95% CI 0.79–0.91) CM-CECT, and 0.90 (95% CI 0.82–0.98) NG-CECT. At DECT, fat concentration was higher in AML (163.7 ± 333.9 [–553.0 to 723.5] vs. –2858.1 ± 460.3 [–2421.2 to –206.0] mg/mL, P<0.001). AUC to diagnose AML using ≥–206.0 mg/mL threshold was 0.98 (95% CI 0.95–1.0) with sensitivity/specificity of 92.0%/96.7%. Of AML, 8.0% (2/25) were incorrectly classified; one of these was fat-poor. AUC was higher for fat concentration compared to HU measurements on CM-CECT and NG-CECT ( P=0.009–0.050) and similar to NECT ( P=0.98). Conclusion DECT material-specific fat images can help confirm the presence of macroscopic fat in renal AML which may be useful to establish a diagnosis if unenhanced CT is unavailable.
Comparing clinical outcomes of image-guided percutaneous transperitoneal and transhepatic cholecystostomy for acute cholecystitis
Authors: Kallini Joseph R , Patel Deven C , Linaval Nikhil , Phillips Edward H , Van Allan Richard J 
Published: September 2020

Background Percutaneous cholecystostomy is performed by interventional radiologists for patients with calculous/acalculous cholecystitis who are poor candidates for cholecystectomy. Two anatomical approaches are widely utilized: transperitoneal and transhepatic. Purpose To compare the clinical outcomes of transperitoneal and transhepatic approaches to cholecystostomy catheter placement. Material and Methods From December 2007 to August 2015, 165 consecutive patients (97 men, 68 women) underwent either transperitoneal (n = 89) or transhepatic (n = 76) cholecystostomy at a single center. Indications were calculous cholecystitis (n = 21), acalculous cholecystitis (n = 35), hydrops (n = 1), gangrenous cholecystitis (n = 1), and other cholecystitis (n = 107). The most common high-risk co-morbidities were sepsis (n = 53) and cardiac (n = 11). Outcomes were compared using univariate and multivariable analysis. Results Post-procedure outcomes included tube dislodgement (transperitoneal [n = 6] and transhepatic [n = 3], P = 0.44), bile leak (transperitoneal [n = 5], transhepatic [n = 1], P = 0.14), gallbladder hemorrhage (transperitoneal [n = 2]; transhepatic [n = 3], P = 0.52), duodenal fistula (transperitoneal [n = 0], transhepatic [n = 1], P = 0.27), repeat cholecystostomy (transperitoneal [n = 1], transhepatic [n = 3], P = 0.27), and repeat cholecystitis requiring separate admission (transperitoneal [n = 6], transhepatic [n = 10], P = 0.15). All complications were Common Terminology Criteria for Adverse Events grade <3. Twenty transperitoneal patients underwent post-procedure cholecystectomy: 13 laparoscopic, three open, and four unclear/outside records. The mean time from cholecystostomy to operation was 38 days (range 3–211 days). Twenty-three transhepatic patients underwent cholecystectomy: 14 laparoscopic, eight open, and one unclear/outside records, with the mean time from cholecystostomy being 98 days (range 0–1053 days). One transhepatic and three transperitoneal patients died during admission. Conclusion There were no significant differences in short-term complications after transperitoneal and transhepatic approaches to percutaneous cholecystostomy catheter placement.
Measures of gluten-related reactivity in children with autism spectrum disorders in the absence of overt gastrointestinal symptoms: a pilot study from the United Arab Emirates
Authors: Abdel-Maksoud Mohamed , Aly El-Gabry Dina , Al Kayoumi Tahani , Alketbi Jamila , Mohamednour Duaa , Elhassan Elamin Mohamed , Subhash Reddy Marri , Al Yafei Zain Ali , Stip Emmanuel , Abdel Aziz Karim , Arnone Danilo 
Published: September 2020

Objectives The aetiology of autism spectrum disorder (ASD) is multifactorial, sometimes genetic, and may be associated with abnormal immunological responses to peptides from proteins such as gluten. These peptides may cross the blood-brain barrier and affect neurotransmission, resulting in behavioural symptoms consistent with ASD. The aim of this study was to screen for markers of gluten-related immune reactivity in the absence of overt gastrointestinal symptoms in patients with ASD in the United Arab Emirates, a country associated with a high prevalence of ASD but lacking this type of research. Methods Patients diagnosed with ASD (using Diagnostic and Statistical Manual of Mental Disorders-IV-based criteria and Autism Diagnostic Observational Schedules) were compared with controls, regarding anti-tissue transglutaminase (tTG) immunoglobulin (Ig) A and anti-deamidated gliadin peptide (DGP) IgA levels. Results Sixty-six patients with ASD and 101 controls were included. Patients with ASD showed statistically significant lower anti-DGP IgA levels, but no significant difference in anti-tTG IgA levels, versus healthy controls. Correlations between immunological data and clinical symptoms were synergistic, but not statistically significant. Conclusion ASD may be associated with reduced levels of anti-DGP IgA.
Pulmonary and pleural metastasis mimicking COVID-19 infection in stage IV ovarian cancer: a case report
Authors: Carbone Fabiana , Palaia Innocenza , Santangelo Giusi , Manganaro Lucia , Perniola Giorgia , Di Donato Violante , Benedetti Panici Pierluigi 
Published: September 2020

Background: The differential diagnosis of lung and pleural metastases and coronavirus disease 2019 (COVID-19) can be challenging. Case: We report a case of a 41-year-old woman with FIGO (International Federation of Gynecology and Obstetrics) stage IV ovarian cancer with pleural and pulmonary spread. After primary cytoreduction was performed, she developed a high fever and worsening dyspnea with desaturation (92% in ambient air). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was suspected, but three swabs gave negative results. Computed tomographic scan showed radiologic imaging strongly suspect for COVID-19 and the patient was transferred to a COVID-19 ward. The final diagnosis was paraneoplastic fever. Conclusion: Lung and pleural metastases can mimic SARS-CoV-2 infection.
Impact of a mobile-based (mHealth) tool to support community health nurses in early identification of depression and suicide risk in Pacific Island Countries
Authors: Chang Odille , Patel Vimla L , Iyengar Sriram , May William 
Published: September 2020

Objective: To convert screening tools for depression and suicide risk into algorithmic decision support on smartphones for use by community health nurses (CHNs), and to evaluate the efficiency, effectiveness, and usability of the mHealth tool in providing mental health (MH) care. Method: Two scenarios of depression and suicide risk were developed and presented to 48 nurses using paper-based and mobile-based guidelines under laboratory (nonclinical) conditions. Participants read through the case scenarios to provide summaries, diagnoses, and management recommendations. Audiotapes were transcribed and analyzed for accuracy in scoring guidelines, therapy decisions, and time for tasks completion. The validated System Usability Scale (SUS) was used to measure mobile app usability. Results: Using mHealth-based guidelines, nurses took significantly less time to complete their tasks, and generated no errors of addition, as compared to paper-based guidelines. Although coding errors were noted when using the mHealth app, it did not influence treatment recommendations. The system usability scores for both guidelines were over 84%. Conclusions: Usable mHealth technology can support task-sharing for CHNs in Fiji, for the efficient and accurate screening of patients for depression and suicide risks in a nonclinical setting. Studies on clinical implementation of the mHealth tool are needed and planned.
The Method of Surgical Lip Repair Affects Speech Outcomes in Children With Bilateral Cleft Lip and Palate
Authors: Peryer Holly , Slator Rona , Thomson Jenny , Richard Bruce 
Published: September 2020

Objective: It was hypothesized that lip repair protocols in children with bilateral cleft lip and palate (BCLP) would affect development of bilabial consonants /m/ /b/ /p/. This study compared speech outcomes in 2 surgical groups. Design: A retrospective case note investigation. Setting: UK Cleft Centre (2000-2009). Patients: Forty-nine children with complete BCLP, of whom 26 had a 1-stage and 23 a 2-stage bilateral cleft lip repair. Interventions: One-stage cleft lip repair versus a 2-staged cleft lip repair. Main Outcome Measures: Bilabial consonant production at 18 months, 3 and 5 years of age. Cleft Speech Characteristics (CSCs) at age 5. Results: At age 18 months, 81% of the 1-stage lip repair group and 4% of the 2-stage lip repair group produced bilabial consonants ( P <·0001, Fisher test). At age 3 years, 81% of the 1-stage and 26% of the 2-stage lip repair groups produced bilabial consonants ( P =·0133, Fisher test). At age 5 years, both groups had similar bilabial consonant production, but children in the 2-stage lip repair group had more frequent and severe CSCs ( P = ·0037, χ2). Conclusion: A 1-stage lip repair for children with complete BCLP resulted in better bilabial consonant production at 18 months and 3 years of age than a 2-stage lip repair. At age 5 years both groups had bilabial consonants but children in the 2-stage lip repair group had worse CSCs. The surgical protocol for bilateral cleft lip repair affected speech outcome in children with BCLP.
Evaluation of Acute Postoperative Pain Management During an Injectable Opioid Shortage
Authors: Tran Kenneth K. , VanDaele Madeline A. , Tran Sylvia , Stevens Shelley A. , Maltese Dietrich Nicole , Franck Andrew J. 
Published: September 2020

Background: Drug product shortages, including injectable opioids, are common and have the potential to adversely affect patient care. Objective: To evaluate the impact of an injectable opioid shortage for hospitalized adult patients in the acute postoperative setting. Methods: A single-center, retrospective cohort study of noncritically ill hospitalized, postoperative patients requiring opioids for acute pain management was conducted. Patient cohorts were compared preshortage and postshortage for proportion of total intravenous (IV) opioids used, proportions of specific pain medications used, subjective pain scores, 30-day mortality, respiratory depression, need for opioid reversal, hospital length of stay, and opioid equivalent doses. Results: A total of 275 patients were included, 130 patients in the preshortage cohort and 145 in the postshortage cohort. The proportion of total IV opioid doses was lower in the postshortage cohort versus the preshortage cohort (16.6% vs 20.5%; P < 0.01). Specific medications used were significantly different between the cohorts. The proportion of severe pain scores was lower in the postshortage cohort versus the preshortage cohort (55.6% vs 58.5%; P = 0.04). No significant differences were seen in the overall proportion of nonopioid analgesic use, 30-day mortality, respiratory depression, need for emergent opioid reversal, hospital length of stay, or opioid equivalent doses between cohorts. Conclusion and Relevance: In hospitalized, postoperative adults, an injectable opioid shortage was associated with significant decreases in IV opioid use and severe pain scores but no significant differences in nonopioid analgesic use, safety outcomes, or opioid equivalent doses. These results may assist clinicians in developing strategies for injectable opioid shortages and generating hypotheses for future studies.