bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of ST7 Alteration Profile, Frequency of Alteration and Correlation with ST7-Related Genes using TCGA Data
Authors: CHARONG Nurdina , PROMKAN Moltira 
Published: November 2020

ST7 (Suppression of Tumorigenicity 7) was reported as a protein playing a role in maintaining cellular structure. This study aims to investigate the ST7 alteration profiles and frequency of alteration in different cancers using data from The Cancer Genome Atlas (TCGA). The correlation between alterations of ST7 and angiogenesis-related genes, SERPINE1, MMP13, and VEGFA, was determined and the relation between ST7 and genes involved in suppression of ST7 transcription, PRMT5 and SMARCA4, were also analyzed. Data of 6 cancer groups from The Cancer Genome Atlas (TCGA) including ovarian serous cystadenocarcinoma (OSC), liver hepatocellular carcinoma (LHC), bladder urothelial adenocarcinoma (BUA), stomach adenocarcinoma (SC), prostate adenocarcinoma (PRAD) and glioblastoma multiforme (GBM) were downloaded for this study. The results indicated that 3 alteration patterns including amplification, missense mutation, and deletion were observed in 6 cancer studies. Gene pair between ST7 and SERPINE1 indicated the co-occurrent alteration in BUC, OSC and SC (p < 0.05). However, no association between alterations of these 2 genes and survival events in our study was observed. Shorter overall survival rate and disease-free survival were found in BUC patients with ST7, PRMT5, and SMARCA4 alterations. These findings suggest that using TCGA data can target the potential genes involved in carcinogenesis. Combining ST7 with PRMT5 and SMARCA4 could be used as indicators for analyzing the patient survival in BUC patients and may serve as the potential therapeutic target for cancer in the future.
Analisa Kapasitas Penampang Sungai Kali Gunting Di Kabupaten Jombang
Authors: Saiful Arfaah  , Iswinarti  
Published: November 2020

The cause of flooding in the watershed area, one of which is caused by the inability of the river profile to accommodate the existing discharge (overflow). This research is intended to examine flood discharge and flood water level profile of Kali Gunting as a first step to determine flood mitigation solutions. Analysis of flood water level profiles using the Hec-Race 4.0 modeling program. With the help of this program, it is expected to be able to accommodate the flow parameters that are so complex. After modeling and knowing the capabilities of each part (cross section), this result will be a technical reference in determining flood mitigation measures.
From the results of the study, the analysis of the potential for flooding in the scissor area was obtained as a result of the flood discharge capacity at scissors times = 301.00m3 / dt, and the emission times = 136.66m3 / dt for the 50th return period. The results of the Q50th calculation show that the condition of K. Scissors P0-P36 river water overflows / floods because the flood water level is above the eksesting embankment, while P36-P46 does not overflow / does not flood because the flood water level is below the eksesting dike. K. Panir condition P0-P48 river water overflows / floods because the flood water level is above the eksesting embankment, while P48-P60 does not overflow / does not flood because the flood water level is below the eksesting embankment
Influence of Acetic Acid on the Integrity and Protectiveness by an Iron Carbonate (FeCO3) Corrosion Product Layer
Authors: Fajardo Vanessa , Eslami Maryam , Choi Yoon-Seok , Brown Bruce , Nešić Srdjan 
Published: November 2020

The effect of undissociated acetic acid on the integrity of an iron carbonate (FeCO3) layer formed on platinum and X65 steel substrates is investigated. Experiments were conducted using buffered solutions with 0.8 mM to 5 mM undissociated acetic acid. For the platinum substrates, changes in the FeCO3 layer were monitored via in situ electrochemical quartz crystal microbalance (EQCM) measurements. This investigation was supported by performing electrochemical experiments, under comparable conditions, on the X65 steel specimens, linking the integrity of FeCO3 layer to its corrosion protection effect. The EQCM measurements revealed that the addition of acetic acid, at all concentrations tested here, caused partial dissolution of the FeCO3 layer. The dissolution occurred selectively, with the outer layer dissolving first, leaving behind an inner FeCO3 layer at the end of the immersion experiment. The electrochemical results revealed that introducing the acetic acid caused a sudden increase in the corrosion rate, which over time returned to a lower value similar in magnitude to that seen before addition of the acetic acid. This was attributed to the protection provided by the inner FeCO3 layer, which was only mildly affected by the addition of acetic acid and was able to repair over time. It was proven that the dissolution of the protective FeCO3 layer in the presence of acetic acid was not due to a small pH change but rather due to the formation of ferrous acetate complexes and changes in ionic strength, which decreases the FeCO3 saturation values.
State of the Journal, 2020
Authors: Reynolds Stacey 
Published: November 2020

Abstract
Throughout this challenging year, the American Journal of Occupational Therapy (AJOT) has stayed committed to publishing high-quality research so that occupational therapy professionals can make informed decisions about best practice. As we look to the future with a new Editor-in-Chief, our goals are to remain the leading journal for our profession while enhancing our engagement with readers, improving our review process, and ensuring that a diverse group of reviewers and associate editors are able to assume leadership positions with the journal.
From Association to Dissociation: The NRP'stranslatioof Gourmont
Authors: Bolduc Michelle 
Published: November 2020

ABSTRACTThis study explores the influence of the French Symbolist poet, novelist, and literary critic Remy de Gourmont on Chaïm Perelman and Lucie Olbrechts-Tyteca's conception of dissociation. It proposes translatio—the medieval trope describing a transfer of ideas—as a lens through which to read the significance of Gourmont's thought on the New Rhetoric Project (NRP). Thus forgoing more traditional comparative approaches such as intertextuality, this study argues that translatio serves here as a particularly valuable conceptual tool: it unveils the evolution of Perelman's thought over time, and Olbrechts-Tyteca's significant contribution to it; it also provides a clearer understanding of the relationship between association (in the guise of analogy) and dissociation in the NRP than what is generally understood by scholars of the Traité. More importantly, translatio unveils the features that make their conception of dissociation one of the truly innovative aspects of the NRP.
Verbal Signatures of Dissociation: Epitomizing and Limiting Cases
Authors: Fahnestock Jeanne 
Published: November 2020

ABSTRACTThe sections devoted to dissociation in The New Rhetoric identify many verbal forms that can express this reconceptualizing line of argument. This article reviews the linguistic options offered in English for epitomizing dissociations, including tautologies and constructions that prompt diverging meanings, orthographical devices like capitalization or subscripts that produce variants of a single word, word schemes like agnominatio and polyptoton that alter core forms, and affixes or modifiers that are either available as antonyms or require forcing apart by subsequent antitheses. Paying attention to the verbal expression of dissociations highlights cases that may or may not qualify as the rich reconceptualizations Perelman and Olbrechts-Tyteca had in mind. Arguments that involve three distinguished terms may, for example, reach a limit where dissociations merge into arguments from division, a long recognized device in traditional rhetoric/dialectic.
The New Rhetoric Project Laughs: Lucie Olbrechts-Tyteca, Dissociation, and the Comic
Authors: Anderson Amy K. 
Published: November 2020

ABSTRACT
Lucie Olbrechts-Tyteca's 1974 chapter on dissociation in the comic furthers our understanding of the rhetorical possibilities of dissociation, revealing how the concept can dismantle old worldviews and create new ones through laughter. Thanks to issues with translation and the chapter's obscure examples, however, this text has been largely overlooked by scholars. This article grounds the chapter's theories in examples with more contemporary resonance as a necessary first step toward understanding the full scope of Olbrechts-Tyteca's contributions to the concept of dissociation. Considering Olbrechts-Tyteca's chapter in light of other texts from the New Rhetoric Project also calls attention to the ways that translation practices have shaped scholars' reception and use of the Project's concepts.
Competition in Markets for Ancillary Services? The Implications of Rising Distributed Generation
Authors: Pollitt Michael G. , Anaya Karim L. 
Published: November 2020

Ancillary services are electricity products which include balancing energy, frequency regulation, voltage support, constraint management and reserves. Traditionally they have been procured by system operators from large conventional power plants, as by-products of the production of energy. This paper discusses the use of markets to procure ancillary services in the face of potentially higher demand for them, caused by rising amounts of intermittent renewable generation. We discuss: the nature of markets for ancillary services; what we really mean by ancillary services; how they are impacted by the rise of distributed generation; how they are currently procured; how they relate to the rest of the electricity system; the current state of evidence on ancillary services markets; whether these markets ever be as competitive as conventional wholesale energy markets, and offer some conclusions.
Pricing and Competition with 100% Variable Renewable Energy and Storage
Authors: Ekholm Tommi , Virasjoki Vilma 
Published: November 2020

Electricity production is a key sector in global decarbonization efforts, and variable renewable energy (VRE) technologies are a primary way to produce carbon-free electricity. We study an electricity market where generation is 100% VRE, while storage and elastic demand resolve temporal supply-demand imbalances. We model hourly market equilibrium to analyze price formation and imperfect, Cournot-type competition with varying levels of ownership concentration. Market power is exerted either with storage-only or with both VRE and storage. In such a system, prices are determined dynamically by demand and intertemporal storage decisions, breaking the static logic of “merit order” with dispatch-able generation. The numerical results indicate that market power with storage has a relatively moderate effect on prices and market efficiency. However, market power exerted with VRE has far larger welfare impacts, resulting from curtailed generation. However, such actions could be more readily observed by a regulator via monitoring.
On eight species of the spider genus Synagelides Strand, 1906 from China (Araneae: Salticidae)
Authors: Wang Cheng , Mi Xiao-Qi , Irfan Muhammad , Peng Xian-Jin 
Published: November 2020

Six new species of Synagelides Strand, 1906 are diagnosed and described: S. bohdanowiczi sp. nov. (♂♀), S. leigongensis sp. nov. (♂♀), S. logunovi sp. nov. (♂♀), S. subgambosus sp. nov. (♂♀), S. wuliangensis sp. nov. (♂♀) and S. xingdouensis sp. nov. (♂♀). The female of S. forkiforma Yang, Zhu &#38; Song, 2007 and the male of S. longus Song &#38; Chai, 1992 are described for the first time. Photos of the habitus and copulatory organs, as well as a distributional map, are provided.
Changes and sex- and age-related differences in the expression of drug metabolizing enzymes in a KRAS-mutant mouse model of lung cancer
Authors: Li Xiaoyan , Lu Yiyan , Ou Xiaojun , Zeng Sijing , Wang Ying , Qi Xiaoxiao , Zhu Lijun , Liu Zhongqiu 
Published: November 2020

Background
This study aimed to systematically profile the alterations and sex- and age-related differences in the drug metabolizing enzymes (DMEs) in a KRAS-mutant mouse model of lung cancer (KRAS mice).

Methodology
In this study, the LC-MS/MS approach and a probe substrate method were used to detect the alterations in 21 isoforms of DMEs, as well as the enzymatic activities of five isoforms, respectively. Western blotting was applied to study the protein expression of four related receptors.

Results
The proteins contents of CYP2C29 and CYP3A11, were significantly downregulated in the livers of male KRAS mice at 26 weeks (3.7- and 4.4-fold, respectively, p < 0.05). SULT1A1 and SULT1D1 were upregulated by 1.8- to 7.0- fold at 20 (p = 0.015 and 0.017, respectively) and 26 weeks (p = 0.055 and 0.031, respectively). There were positive correlations between protein expression and enzyme activity for CYP2E1, UGT1A9, SULT1A1 and SULT1D1 (r2 ≥ 0.5, p < 0.001). Western blotting analysis revealed the downregulation of AHR, FXR and PPARα protein expression in male KRAS mice at 26 weeks. For sex-related differences, CYP2E1 was male-predominant and UGT1A2 was female-predominant in the kidney. UGT1A1 and UGT1A5 expression was female-predominant, whereas UGT2B1 exhibited male-predominant expression in liver tissue. For the tissue distribution of DMEs, 21 subtypes of DMEs were all expressed in liver tissue. In the intestine, the expression levels of CYP2C29, CYP27A1, UGT1A2, 1A5, 1A6a, 1A9, 2B1, 2B5 and 2B36 were under the limitation of quantification. The subtypes of CYP7A1, 1B1, 2E1 and UGT1A1, 2A3, 2B34 were detected in kidney tissue.

Conclusions
This study, for the first time, unveils the variations and sex- and age-related differences in DMEs in C57 BL/6 (WT) mice and KRAS mice.
Pulsed Gate Switching of MoS2 Field‐Effect Transistor Based on Flexible Polyimide Substrate for Ultrasonic Detectors
Authors: Naqi Muhammad , Kim Bosung , Kim Sang‐Woo , Kim Sunkook 
Published: November 2020

AbstractMolybdenum disulfide (MoS2) semiconductors have closely been studied for potential applications in detectors, optoelectronics, and flexible electronics due to its high electrical and robust mechanical performance. Herein, the first experimental study of the high‐speed ultrasound wave detection by the combinational structure of flexible MoS2 field‐effect transistor (FET) and piezoelectric device based on polyvinylidene fluoride trifluoro ethylene P(VDF‐TrFE) is reported. The proposed flexible MoS2 based FET device exhibits maximum mobility of 18.12 cm2 Vs−1, high on/off current ratio of ≈105, high robustness over mechanical tests, and excellent gate‐pulsed switching behavior at different frequencies (10, 100, and 500 kHz), thus, utilized as supporting electronics to detect ultrasound wave at high‐speed. The ultrasound waves are applied to the self‐assembled piezoelectric device under different power scales (0 ≈ 1.5 W cm−2) and the transfer curve of the proposed FET is analyzed. The results show a clear detection of ultrasound waves with high stability and excellent linearity in terms of threshold voltage (Vth) shift and drain current (Ids) under different power levels. Also, the pulsed gate‐switching behavior is analyzed and the ultrasound detection with high stability is observed at high‐speed switching, thus, enabling the development of applications in high‐speed electronic devices and biomedical imaging tools.
Halohydrin Dehalogenases and Their Potential in Industrial Application – A Viewpoint of Enzyme Reaction Engineering
Authors: Findrik Blažević Zvjezdana , Milčić Nevena , Sudar Martina , Majerić Elenkov Maja 
Published: November 2020

AbstractAt the moment, there are approx. 100 published papers investigating halohydrin dehalogenases from different aspects; enzymology, molecular biology and reactions they can catalyse. Unquestionably, these enzymes are of great importance and hold an immense potential due to the wide spectrum of different compounds that can be synthesized by their action. These compounds, such as chiral epoxides, β‐substituted alcohols, oxazolidinones etc., significantly enrich the chemist's toolbox and, moreover, open the possibility for the synthesis of even more complex compounds. Still, there are many unknowns, and it is the purpose of this work to demonstrate the possibilities and bottlenecks, in scientific sense, that could further help in broadening the applicative potential of these fascinating enzymes.magnified image
Pd(II)‐catalyzed, Picolinamide‐aided sp2 γ−C−H Functionalization of Phenylglycinol: Access to γ−C−H Arylated, Alkylated and Halogenated Phenylglycinol Scaffolds
Authors: Singh Prabhakar , Arulananda Babu Srinivasarao , Aggarwal Yashika , Patel Pooja 
Published: November 2020

AbstractWe report the Pd(II)‐catalyzed picolinamide‐aided ortho‐C−H arylation‐, alkylation‐, and halogenation (sp2 γ−C−H functionalization) of phenylglycinol substrates. Phenylglycinols are remarkable building blocks and have found different applications in synthetic organic and medicinal chemistry. This work is a contribution towards the expansion of the library of phenylglycinol scaffolds and also substrate scope development by using the Pd(II)‐catalyzed bidentate directing group picolinamide‐aided C−H activation tactic.
Environmental Control of Single‐Molecule Junction Evolution and Conductance: A Case Study of Expanded Pyridinium Wiring
Authors: Nováková Lachmanová Štěpánka , Kolivoška Viliam , Šebera Jakub , Gasior Jindřich , Mészáros Gábor , Dupeyre Grégory , Lainé Philippe P. , Hromadová Magdaléna 
Published: November 2020

AbstractEnvironmental control of single‐molecule junction evolution and conductance was demonstrated for expanded pyridinium molecules by scanning tunneling microscopy break junction method and interpreted by quantum transport calculations including solvent molecules explicitly. Fully extended and highly conducting molecular junctions prevail in water environment as opposed to short and less conducting junctions formed in non‐solvating mesitylene. A theoretical approach correctly models single‐molecule conductance values considering the experimental junction length. Most pronounced difference in the molecular junction formation and conductance was identified for a molecule with the highest stabilization energy on the gold substrate confirming the importance of molecule–electrode interactions. Presented concept of tuning conductance through molecule–electrode interactions in the solvent‐driven junctions can be used in the development of new molecular electronic devices.
Unveiling the Activity Origin of Iron Nitride as Catalytic Material for Efficient Hydrogenation of CO2 to C2+ Hydrocarbons
Authors: Zhao Bohang , Sun Mengyao , Chen Fanpeng , Shi Yanmei , Yu Yifu , Li Xingang , Zhang Bin 
Published: November 2020

AbstractDeveloping efficient catalytic materials and unveiling the active species are significant for selective hydrogenation of CO2 to C2+ hydrocarbons. Fe2N@C nanoparticles were reported to exhibit outstanding performance toward selective CO2 hydrogenation to C2+ hydrocarbons (C2+ selectivity: 53.96 %; C2‐C4= selectivity, 31.03 %), outperforming corresponding Fe@C. In situ X‐ray diffraction, ex situ Mössbauer and X‐ray photoelectron spectra revealed that iron nitrides were in situ converted to highly active iron carbides, which acted as the real active species. Moreover, the combined results of in situ diffuse reflectance infrared Fourier transform spectroscopy and control experiments suggested an in situ formed carbonyl iron‐mediated conversion mechanism from iron nitrides to iron carbides.
Azide Radical Initiated Ring Opening of Cyclopropenes Leading to Alkenyl Nitriles and Polycyclic Aromatic Compounds
Authors: Muriel Bastian , Waser Jerome 
Published: November 2020

AbstractWe report herein a radical‐mediated amination of cyclopropenes. The transformation proceeds through a cleavage of the three‐membered ring after the addition of an azide radical on the strained double bond and leads to tetrasubstituted alkenyl nitrile derivatives upon loss of N2. With 1,2‐diaryl substituted cyclopropenes, this methodology could be extended to a one‐pot synthesis of highly functionalized polycyclic aromatic compounds (PACs). This transformation allows the synthesis of nitrile‐substituted alkenes and aromatic compounds from rapidly accessed cyclopropenes using only commercially available reagents.
Synthesis of Indanones and Spiroindanones by Diastereoselective Annulation Based on a Hydrogen Autotransfer Strategy
Authors: Chen Yate , Ding Zhengtian , Wang Yiming , Liu Wenfeng , Kong Wangqing 
Published: November 2020

AbstractAn unprecedented nickel‐catalyzed domino reductive cyclization of alkynes and o‐bromoaryl aldehydes is described. The reaction features broad substrate scope and is tolerant of a variety of functional groups, providing straightforward access to biologically significant indanones and spiroindanone pyrrolidine derivatives in good yields with excellent regio‐ and diastereoselectivity. Preliminary mechanistic studies have shown that indanones are formed by the cyclization of o‐bromoaryl aldehydes and alkynes to form indenol intermediates, followed by hydrogen autotransfer.
Self‐Supported Mesoporous Iron Phosphide with High Active‐Site Density for Electrocatalytic Hydrogen Evolution in Acidic and Alkaline Media
Authors: Huang Guoqing , Zhang Cong , Liu Zhipeng , Yuan Shisheng , Yang Guohua , Wang Kaiwen , Li Xiaotian , Li Nan , Jing Shubo 
Published: November 2020

AbstractDeveloping low‐cost and highly active electrocatalysts for the hydrogen evolution reaction (HER) is urgently desired. We fabricated a mesoporous FeP self‐supported electrode (meso‐FeP/CC) through a facile and mild sol‐gel method. The mesoporous FeP self‐supported electrode displays superior HER electrocatalytic activity, requiring low overpotentials of 57 and 84 mV to drive 10 mA cm−2 in acidic and alkaline electrolyte, respectively. Meanwhile, the as‐prepared electrode exhibits fast kinetics with a small Tafel slope (acidic media: 42 mV dec−1 and alkaline media: 60 mV dec−1). The excellent catalytic performance of the electrode benefits from mesoporous framework with a large surface area (74.1 m2 g−1) and highly conductive self‐supported structure. The former endows the catalyst with a large active‐site density (3.5×1018 site per mg) and substantial accessible mesopores, and the latter accelerates reaction kinetics. This work offers a new avenue for rational designing high‐efficiency FeP HER electrocatalysts.
Chemodivergence between Electrophiles in Cross‐Coupling Reactions
Authors: Reeves Emily K. , Entz Emily D. , Neufeldt Sharon R. 
Published: November 2020

AbstractChemodivergent cross‐couplings are those in which either one of two (or more) potentially reactive functional groups can be made to react based on choice of conditions. In particular, this review focuses on cross‐couplings involving two different (pseudo)halides that can compete for the role of the electrophilic coupling partner. The discussion is primarily organized by pairs of electrophiles including chloride vs. triflate, bromide vs. triflate, chloride vs. tosylate, and halide vs. halide. Some common themes emerge regarding the origin of selectivity control. These include catalyst ligation state and solvent polarity or coordinating ability. However, in many cases, further systematic studies will be necessary to deconvolute the influences of metal identity, ligand, solvent, additives, nucleophilic coupling partner, and other factors on chemoselectivity.
Synthesis of Acrylonitriles via Mild Base Promoted Tandem Nucleophilic Substitution‐Isomerization of α‐Cyanohydrin Methanesulfonates
Authors: Liu Shiwen , Meng Lingling , Zeng Xiaojun , Hammond Gerald B. , Xu Bo 
Published: November 2020

AbstractMain observation and conclusionWe have developed an efficient synthesis of acrylonitriles via mild base promoted tandem nucleophilic substitution‐isomerization of α‐cyanohydrin methanesulfonates with alkenylboronic acids. This transition metal‐free protocol works under simple and mild conditions and offers good chemical yields for a wide range of substrates and demonstrates good functional group tolerance.image