bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduced serum BDNF levels are associated with the increased risk for developing MDD: A case-control study with or without antidepressants therapy
Authors: Emon Md. Prova Zaman , Das Rajesh , Nishuty Nuruna Lovely , Qusar M.M.A. Shalahuddin , Bhuiyan Mohiuddin Ahmed , Islam Md. Rabiul 
Published: December 2019

Abstract
Objective We do not have any consistent markers for major depressive disorder (MDD) though various biological factors are involved in the pathophysiology. We aimed to evaluate the serum brain-derived neurotrophic factor (BDNF) levels in MDD patients with or without antidepressant therapy compared to healthy controls (HCs). Results We assessed serum BDNF levels among three groups: drug-naïve MDD patients (n = 41), drug-treated MDD patients (n = 44), and age-and sex-matched HCs (n = 82). Serum BDNF levels were measured by enzyme-linked immunosorbent assay (ELISA) kit. Serum levels of BDNF were detected significantly lower in drug-naïve MDD patients compared to HCs. No significant alterations of serum BDNF levels between drug-treated patients and HCs were identified. Significant negative correlations between serum BDNF levels and Hamilton depression rating (Ham-D) scores were observed in both drug-naïve and drug-treated MDD patients. Receiver operating characteristic (ROC) analysis showed good diagnostic value for serum BDNF levels in drug-naïve MDD patients with the area under the curve at 0.821. The present study suggests that low serum BDNF levels may be involved in the pathophysiology of MDD. The reduced serum BDNF levels might be used as an early risk assessment marker for major depression.
Principal Component Analysis of Adipocytokines and Insulin Associate with Risk Factors of Cardiovascular Diseases
Authors: yarizadeh Habib , Pooyan Sara , sajjadi Seyedeh Forough , Badruj Negin , Mirzaei Khadijeh 
Published: December 2019

Abstract
Objectives: Obesity plays an important role in the development of chronic diseases like cardiovascular diseases and diabetes. The underlying mechanism of this connection is that adipose tissue secretes an array of chemical messenger adipokines proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, interleukin-1- beta).Result: Two patterns were identified. The first pattern was galectin-3, plasminogen activator inhibitor-1 and IL-1β and the second one was C-reactive protein, insulin and monocyte chemoattractant protein-1. The second pattern were strongly associated with the higher scores for resting metabolic rate, diastolic blood pressure, homeostasis model insulin resistance index, lipid profile (except low density lipoprotein, total cholesterol), and body composition parameters (except fat free mass index and waist hip ratio), while negatively associated with age and high density lipoprotein level (all p < 0.05). The first pattern was, however, significantly associated with body fat mass, obesity degree percentage, waist circumference, fat mass index, and waist hip ratio (P < 0.05 for all). Keywords: Adipocytokines, Cardiovascular Diseases, Obesity.
The Prevalence and Correlates of Physical Activity/Inactivity and Sedentary Behaviour among High-School Adolescents in Iran: A Cross-Sectional Study
Authors: ZIAEI REZA , Mohammadi Reza , Dastgiri Saeed , Baybordi Elaheh , Rahimi Vahab Asl , Bazargani Homayoun Sadeghi , Viitasara Eija 
Published: December 2019

Abstract
Background Physical inactivity and sedentary behaviour are the main risk factors for non-communicable diseases in all stages of life. However, there is a lack of reliable data regarding the recommended level of physical activity and its correlates related to physical inactivity and sedentary behaviour among school students in Iran. The aim of the present study was to report the prevalence and correlates of physical activity/ inactivity and sedentary behaviour among Iranian high school adolescents.Methods The Global School-based Student Health Survey (GSHS) was used for data collection. Related data comprising socio-demographics, health risk behaviour, and protective factors were obtained from 1,517 high school students. Multivariate logistic regression was used to assess the association between relevant independent variables (e.g. gender) and the dependent outcome variable (physical inactivity/sedentary behaviour).Results The prevalence of recommended physical activity by WHO was 27.8%, physical inactivity 72.2% and sedentary behaviour 71.4%. Being female, being overweight or obese, walking/cycling to or from school on 1-4 days, sitting 3 or more hours/day (sedentary behaviour), insufficient vegetable intake, being bullied, and lack of parental support, peer support and parental connectivity (protective factors) were positively associated with physical inactivity. On the other hand, walking/cycling to or from school on 5-7 days, and inadequate fruit intake was negatively associated with physical inactivity. Walking/cycling to or from school on 1-4 days, being physically inactive, inadequate fruit intake, and being bullied were positively associated with sedentary behaviour.Conclusion The prevalence of physical inactivity and sedentary behaviour was high in our studied sample. Interventions that address the issue of active school transport, sedentary behaviour, fruit and vegetable intake, family and peer support and bullying should be given more priority by the public health authorities.
Genome-wide association study of seed coat color in sesame (Sesamum indicum L.)
Authors: Mei Hongxian , Cui Chengqi , Liu Yanyang , Liu Yan , Cui Xianghua , Du Zhenwei , Wu Ke , Jiang Xiaolin , Zheng Yongzhan , Zhang Haiyang 
Published: December 2019

Abstract
Background: Sesame (Sesamum indicum L.) is an important and ancient oilseed crop. Sesame seed coat color is an extremely important agronomic trait, and is related to biochemical functions involved in protein and oil metabolism, and antioxidant content. Because of its complication, the genetic basis of sesame seed coat color remains poorly understood.Results: Genome-wide association study (GWAS) using 42,781 SNPs was performed with a diverse association-mapping panel comprising 366 sesame germplasm lines in 12 environments. In total, 224 significant SNPs (P < 2.34×10−7) explaining approximately 13.34% of the phenotypic variation on average were identified, and 35 significant SNPs were detected in more than 6 environments. Out of 224 significant SNPs, 22 were located in the confidence intervals of previous reported quantitative trait loci (QTLs). A total of 92 candidate genes were identified in the vicinity of the 4 SNPs that were most significantly associated with sesame seed coat color. Conclusions: The results in this paper will provide new insights into the genetic basis of sesame seed coat color, and should be useful for molecular breeding in sesame.
Enhancing the circular economy with nature-based solutions in the built urban environment: green building materials, systems and sites
Authors: Pearlmutter David , Theochari Dimitra , Nehls Thomas , Pinho Pedro , Piro Patrizia , Korolova Alisa , Papaefthimiou Spiros , Mateo Mari Carmen Garcia , Calheiros Cristina , Zluwa Irene , Pitha Ulrike , Schosseler Paul , Florentin Yaakov , Ouannou Shahar , Gal Erez , Aicher Andreas , Arnold Killian , Igondová Erika , Pucher Bernhard 
Published: December 2019

Abstract
The objective of this review paper is to survey the state of the art on nature-based solutions (NBS) in the built environment, which can contribute to a circular economy (CE) and counter the negative impacts of urbanization through the provision of ecosystem services. NBS are discussed here at three different levels: (i) green building materials, including biocomposites with plant-based aggregates; (ii) green building systems, employed for the greening of buildings by incorporating vegetation in their envelope; and (iii) green building sites, emphasizing the value of vegetated open spaces and water-sensitive urban design. After introducing the central concepts of NBS and CE as they are manifested in the built environment, we examine the impacts of urban development and the historical use of materials, systems and sites which can offer solutions to these problems. In the central section of the paper we present a series of case studies illustrating the development and implementation of such solutions in recent years. Finally, in a brief critical analysis we look at the ecosystem services and disservices provided by NBS in the built environment, and examine the policy instruments which can be leveraged to promote them in the most effective manner – facilitating the future transition to fully circular cities.
Психологическая концепция преодоления: теория, методология, диагностика
Authors: Андреев Виталий В. , Андреев Владимир В. 
Published: December 2019

Introduction. This paper (a) provides an overview of various theoretical and methodological approaches to studying the concept of ‘overcoming’, (b) presents terminological, semantic, and functional approaches to the analysis of the concept of ‘overcoming’ in the structure of athletes’ self-consciousness, and (c) demonstrates associations between the phenomenon of ‘will’ and the concept of ‘overcoming’ from various perspectives. In particular, we examine philosophical, psychological, pedagogical, psychophysiological, and socio-psychological determinants that influence our approach to studying the phenomenon of overcoming. This study represents a first attempt to carry out the methodological, theoretical, and critical analysis of the issue of overcoming in psychology. We systematized previous ideas and concepts about the phenomenon of ‘overcoming’, formulated our working definition of this concept, and distinguished levels of overcoming. For the first time, the phenomenon of ‘overcoming’ is comprehensively studied in terms of physical and psychological regulatory determinants.
Theoretical Basis. We discuss in detail basic theories, principles, and concepts including the dialectical principle, the principle of transgressiveness, the principle of stable disequilibrium of living systems, and the principle of self-determination. This section (a) provides the main conceptual framework for the psychological theory of overcoming, (b) considers the impact of the concept of resilience, the extra-situational theory of activity, the idea of passionarity and liminality, and (c) concentrates on the psychology of extreme situations, psychological barriers, and risk issues. Explanatory determinants of the phenomenon of overcoming include the ‘freedom reflex’ and the ‘goal reflex’ by I. P. Pavlov, the ‘principle of dominance’ by A. A. Ukhtomsky, the synergistic ideas of the ‘concept of nonequilibrium systems’ by I. Prigogine, the ‘concept of passionarity’ by L. Gumilev, and conceptual perspectives of P. K. Anokhin, B. G. Ananiev, N. A. Bernshtein, E. S. Bauer and other scientists.
Results and Discussion. We elaborated a scheme for functional analysis of retrospective autobiographical questionnaire data and also developed an algorithm for semantic analysis of empirical data. The results of the content analysis enabled us to introduce a structural and dynamic characteristic of the phenomenon of overcoming and to clarify psychological parameters of the concepts of ‘will’ and ‘overcoming’. We (a) carried out the semantic analysis of various concepts of the phenomenon of overcoming, (b) introduced a level-based concept of overcoming, and (c) attempted to conceptualize the concept of ‘will’ and its associations with the paradigm of ‘overcoming’.
Теоретические подходы к изучению эффектов неопределенности в процессах смысловой регуляции развития личности
Authors: Абакумова Ирина В. , Годунов Михаил В. , Голубова Вера М. 
Published: December 2019

Introduction. The article hopes to provide a theoretical analysis of research papers dedicated to the way various uncertainty effects influence personality development. The uncertainty phenomenon has to be considered due to the research field enhancement while elaborating adequate patterns of personality development meaning regulation.
Theoretical Basis. Uncertainty effects are revealed epistemically and ontologically in the objective sphere, and existentially and phenomenologically in the subjective sphere.
Results. Epistemically uncertainty effects are a changeable level of cognitive reflection; continuity of certainty and uncertainty; ambiguous, incomplete and insufficient information; lack of human knowledge about human abilities; disregard for casualties and anomalies; blurred and multiple current psychological paradigms. Ontologically uncertainty effects are relativity of existence; development points with equal probability; a chance of synergistic effect; different human abilities of achieving goals within their existence; aspiration to gain new personal experience; different susceptibility to development pathway deviations. Existentially uncertainty effects are the absence of well-defined external clues in search of life purpose; personality development crises; discrepancy in tolerance levels towards uncertainty; discrepancy in credibility levels towards the world; nonidentity of individuals’ personal experiences; different ideas of action purposes; discrepancy in contradiction levels of interaction between an individual and the society; an unbalanced combination of rational and emotional perception; impossibility of permanent psychological comfort. Phenomenologically uncertainty effects are success and failure expectation risks; different motivation levels; “learned helplessness”; learning interferences due to implicit knowledge; lack of time for reflection over decisions; a subconscious phase of decision making; conscious and subconscious meaning attribution.
Discussion. An individual has to act under the influence of many uncertainty effects. Taking this into consideration allows a more full-fledged theoretical and empiric study of personality development processes.
Recent Advances in Applications of Supported Ionic Liquids
Authors: Kaur Pawanpreet , Chopra Harish Kumar 
Published: December 2019

:
The supported ionic liquids have shown immense potential for numerous applications
in catalysis and separation science. In the present review, the remarkable contribution
of supported ionic liquids has been highlighted. The main emphasis has been laid on
describing the facile separation of gas from binary gas mixtures owing to the capability of
selective transport of permeable gases across supported membranes and removal of environmentally
hazard sulfur compounds from fuels. The catalytic action of supported ionic
liquids has been discussed in other applications such as biodiesel (biofuel) synthesis by
transesterification/esterification processes, waste CO2 fixation into advantageous cyclic
carbonates, and various chemical transformations in organic green synthesis. This review
enclosed a maximum of the published data of the last ten years and also recently accomplished
work concerning applications in various research areas like separation sciences, chemical transformations
in organic green synthesis, biofuel synthesis, waste CO2 fixation, and purification of fuels by desulfurization.
Dose-related Effects of Resveratrol in Different Models of Pulmonary Arterial Hypertension: A Systematic Review
Authors: Ferreira Andressa C. , Serejo Jerdianny S. , Durans Rafael , Pereira Costa Jadna M. , Maciel Antonio W.S. , Vieira Adeilson S.M. , Dias-Filho Carlos A. A. , Dias Carlos J. , Bomfim Maria R.Q. , Mostarda Cristiano T. , Brito-Monzani Janaina de O. 
Published: December 2019

Background:Pulmonary Arterial Hypertension (PAH) is a severe and progressive disease of pulmonary arterioles. This pathology is characterized by elevation of the pulmonary vascular resistance and pulmonary arterial pressure, leading to right heart failure and death. Studies have demonstrated that resveratrol possesses a protective effect on the mechanisms related to the genesis of the PAH-induced by different models.Objective:This study aimed to investigate the dose-related effects of resveratrol in different models of pulmonary arterial hypertension.Methods:To identify eligible papers, we performed a systematic literature search on Scielo, Pub- Med, and Scholar Google. The research was limited to articles written in English in the last 10 years. We used the following descriptors to search: Pulmonary Arterial Hypertension and Resveratrol, OR Resveratrol, and Animal models of Pulmonary Arterial Hypertension, OR Resveratrol, and in vitro models of Pulmonary Arterial Hypertension.Results:1724 studies were identified through the descriptors used, fifty-five studies with different models of pulmonary arterial hypertension were selected for the full review, forty-four were excluded after application of exclusion and inclusion criteria, totalizing eleven studies included in this systematic review.Conclusion:The results showed that resveratrol, at low and high doses, protects in a dosedependent manner against the development of PAH induced through monocrotaline, normoxia and hypoxia models. In addition to having chemopreventive, anti-inflammatory, antioxidant and antiproliferative properties. In the case of PAH-related myocardial injury, resveratrol protects cells from apoptosis, thus working as an antiapoptotic agent.
Fabrication Technologies and Applications of Graphene-based co-polymeric Nano-composites: its challenges and Future works
Authors: Chhapia Pratik , Patel Harshad 
Published: December 2019

:
Graphene based co-polymeric Nano-composites explored and trending in various applications as ascribing to its enhanced conductivity and controlled modification with wide specific surface areas. With the number of advantages of co-polymeric coating on Graphene or Graphene sheets and their derivatives, Graphene based co-polymeric Nano-composites fabricated by various techniques (deposition, ink jet, electro spinning, spin coating, in-situ techniques, etc.) and different conducting co-polymers show its exceptional chemical, mechanical, electrical and optical properties. Therefore, in the today’s world with greater quantities of various properties of co-polymer with Graphene based Nano-composites with enhanced stability, selectivity and sensitivity have been formed. In this review paper, we have particularly focused on recent advancing in fabrication of different technologies with the help of Graphene based co-polymeric Nano-composites and its various trending and future applications. Finally, on the personal standpoint; the key challenges of Graphene based co-polymeric Nano-composites are mentioned in hope to shed a light on their potential future prospects.
A Practical Conflicting Role-Based Cloud Security Risk Evaluation Method
Authors: Han Jin , Zhan Jing , Xia Xiaoqing , Fan Xue 
Published: December 2019

Background:
Currently, Cloud Service Provider (CSP) or third party usually proposes
principles and methods for cloud security risk evaluation, while cloud users have no choice but to
accept them. However, since cloud users and cloud service providers have conflicts of interests,
cloud users may not trust the results of security evaluation performed by the CSP. Different cloud
users may have different security risk preferences, which makes it difficult for the third party to consider
all users' needs during evaluation. In addition, current security evaluation indexes for the cloud
are too impractical to test (e.g., indexes like interoperability, transparency, portability are not easy to
be evaluated).

Methods:
To solve the above problems, this paper proposes a practical cloud security risk evaluation method of decision-making based on conflicting roles by using the Analytic Hierarchy Process (AHP) with Aggregation of Individual priorities (AIP).

Results:
Not only can our method bring forward a new index system based on risk source for cloud security and corresponding practical testing methods, but also can obtain the evaluation result with the risk preferences of conflicting roles, namely CSP and cloud users, which can lay a foundation for improving mutual trusts between the CSP and cloud users. The experiments show that the method can effectively assess the security risk of cloud platforms and in the case where the number of clouds increased by 100% and 200%, the evaluation time using our methodology increased by only by 12% and 30%.

Conclusion:
Our method can achieve consistent decision based on conflicting roles, high scalability and practicability for cloud security risk evaluation.
Pengembangan media pembelajaran berbasis mobile learning pada mata pelajaran simulasi digital
Authors: Rahmat Riki Fajri , Mursyida Lativa , Rizal Fahmi , Krismadinata Krismadinata , Yunus Yuliawati 
Published: December 2019

Penggunaan smartphone di kalangan pelajar sebagian besar digunakan untuk mengakses jejaring sosial dan belum menggunakan smartphone dalam poroses pembelajaran. Tujuan Penelitian ini untuk merancang media pembelajaran mobile learning pada mata pelajaran simulasi digital berbasis android. Model yang digunakan adalah Instructional Development Institute (IDI) dalam metode pengembangan Research and Development (R&D). Hasil penelitian ini menunjukkan bahwa mobile learning berbasis android untuk mata pelajaran simulasi digital ini layak untuk dimanfaatkan sebagai media pendukung pembelajaran mandiri, sesuai dengan pengujian yang dilakukan terhadap aspek materi dan desain yang diujikan ke siswa didapatkan hasil untuk kelas kontrol sebesar 74,125% dan eksperimen sebesar 83,25%. Sehingga dapat diambil kesimpulan penggunaan media mobile learning berbasis android ini valid, praktis dan efektif digunakan pada mata pelajaran simulasi digital. Mobile learning simulasi digital ini dapat meningkatkan minat belajar siswa dan juga meningkatkan hasil belajar siswa. Diharapkan untuk guru dan kepala sekolah SMKN 2 Padang agar dapat mempergunakan mobile learning dalam pembelajaran.Kata kunci: mobile learning, research and development, simulasi digital Development of learning media based on mobile learning in digital simulation subjectsAbstractThe use of smartphones among students is mostly used to access social networks and have not used smartphones in learning processes. The purpose of this study is to support mobile learning media on android-based digital learning. The model used is the Instructional Development Institute (IDI) in the Research and Development (R&D) development method. The results of this study indicate that android-based mobile learning for digital simulation subjects is feasible to be used as a supporting medium for independent learning, in accordance with tests conducted on material and design aspects that are tested for students who obtain results for the control class by 74.125% and trials for 83, 25%. It can be concluded that the use of mobile learning media based on Android is valid, practical and effective in digital simulation lessons. This digital simulation of mobile learning can increase student learning interest and also improve student learning outcomes. It is expected that teachers and principals of SMKN 2 Padang can use mobile learning in learning.Keywords: mobile learning, research and development, digital simulation