bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Ultrasound‐Excitable Aggregation‐Induced Emission Dye for Enhanced Sonodynamic Therapy of Tumors
Authors: Zeng Weiwei , Xu Yan , Yang Weitao , Liu Kai , Bian Kexin , Zhang Bingbo 
Published: July 2020

AbstractUltrasound (US)‐triggered sonodynamic therapy (SDT) can significantly solve the problem of tissue penetrability of light of photodynamic therapy (PDT) that has long vexed physicians in clinics. However, there is a great shortage of sonosensitizers for SDT. Currently, several photosensitizers and their derivatives have been reported for SDT but these dyes are usually quenched when aggregated due to aggregation‐caused quenching (ACQ) effect. In this work, aggregation‐induced emission (AIE) dye (TTMN) assembled nanoparticles (S‐AIE) are synthesized and employed as sonosensitizers for enhanced SDT due to the unique properties of the AIE dye and the deep tissue penetration of ultrasound. Results show that S‐AIE can generate potent singlet oxygen (1O2) under US irradiation to induce cancer cells apoptosis and clearly inhibit tumor growth in vitro and in vivo. In particular, the intrinsic fluorescence of AIE dye can guide the procedure of SDT. To the best of current knowledge, this is the first demonstration of AIE dyes being used as sonosensitizers for SDT and importantly, this work could inspire other more efficient AIE dyes for being used as sonosensitizers for SDT of deep‐seated tumors.
Opto‐E‐Dura: A Soft, Stretchable ECoG Array for Multimodal, Multiscale Neuroscience
Authors: Renz Aline F. , Lee Jihyun , Tybrandt Klas , Brzezinski Maciej , Lorenzo Dayra A. , Cerra Cheraka Mouna , Lee Jaehong , Helmchen Fritjof , Vörös Janos , Lewis Christopher M. 
Published: July 2020

AbstractSoft, stretchable materials hold great promise for the fabrication of biomedical devices due to their capacity to integrate gracefully with and conform to biological tissues. Conformal devices are of particular interest in the development of brain interfaces where rigid structures can lead to tissue damage and loss of signal quality over the lifetime of the implant. Interfaces to study brain function and dysfunction increasingly require multimodal access in order to facilitate measurement of diverse physiological signals that span the disparate temporal and spatial scales of brain dynamics. Here the Opto‐e‐Dura, a soft, stretchable, 16‐channel electrocorticography array that is optically transparent is presented. Its compatibility with diverse optical and electrical readouts is demonstrated enabling multimodal studies that bridge spatial and temporal scales. The device is chronically stable for weeks, compatible with wide‐field and 2‐photon calcium imaging and permits the repeated insertion of penetrating multielectrode arrays. As the variety of sensors and effectors realizable on soft, stretchable substrates expands, similar devices that provide large‐scale, multimodal access to the brain will continue to improve fundamental understanding of brain function.
A pH‐Sensitive Self‐Assembled and Carrier‐Free Nanoparticle Based on Charge Reversal for Enhanced Synergetic Chemo‐Phototherapy
Authors: Liu Chen , Liu Qiuhong , Chen Luping , Li Mao , Yin Jieli , Zhu Xuan , Chen Dengyue 
Published: July 2020

AbstractTo overcome biological barriers for nanoparticles (NPs) efficaciously accumulated at tumor sites, as well as enhancing the performance of drug delivery systems, a carrier‐free nanoparticle based on charge reversal is designed for improved synergetic chemo‐phototherapy for cancer treatment. In this system, doxorubicin (Dox) and zinc phthalocyanine (ZnPc) are self‐assembled through noncovalent interactions (π–π stacking, hydrophobic forces) to avoid the possible toxicity of excipient, complex chemical conjugations and batch‐to‐batch variation. A trace amount of poly(2‐(di‐methylamino) ethylmethacrylate)‐ poly[(R)‐3‐hydroxybutyrate]‐ poly(2‐(dimethylamino) ethylmethacrylate (PDMAEMA‐PHB‐PDMAEMA) is modified on the surface of Dox–ZnPc to construct the novel nanoparticles, namely DZP, with long‐term stability, and with a dual‐drug load content of up to ≈90％. The drug delivery system (DDS) can effectively decrease its toxicity among physical circulation and increase the accumulation at the tumor site. Moreover, the developed DZP nanoparticles show excellent photo‐chemotherapy, photoacoustic (PA) and fluorescence (FL) imaging characteristics for multimodal imaging‐guided synergetic therapy.
Steering Hollow Multishelled Structures in Photocatalysis: Optimizing Surface and Mass Transport
Authors: Wei Yanze , Yang Nailiang , Huang KeKe , Wan Jiawei , You Feifei , Yu Ranbo , Feng Shouhua , Wang Dan 
Published: July 2020

AbstractHollow multishelled structures (HoMSs) provide a promising platform for fabricating photocatalysts, because the unique structure optimizes the effective surface and mass transport, showing enhanced light absorption, optimized mass transport and highly effective active sites exposed. Subsequently, the rational design on HoMS photocatalytsts is elaborated to boost the photocatalytic activity with efforts in all dimensions, from nanoscale to microscale. Breakthroughs in synthetic methodology of HoMSs have greatly evoked the prosperous photocatalytic researches for HoMSs since the developing of sequential templating approach in 2009. The dawn of HoMS photocatalyst is coming after revealing the temporal‐spatial ordering property, which is also discussed in this paper with pioneer works demonstrating the greatly enhanced energy/mass transfer processes. Some insights into the key challenges and perspectives of HoMSs photocatalysts are also discussed. With the reviewed fate and future of HoMSs photocatalysts, hopefully new concepts and innovative works can be inspired to flourish this sun‐rise field.
One‐Pot Tandem Protocol for the Synthesis of 1,3‐Bis(β‐aminoacrylate)‐Substituted 2‐Mercaptoimidazole Scaffolds
Authors: Luo Jian , Chen Guo‐Shu , Chen Shu‐Jie , Li Zhao‐Dong , Zhao Yu‐Lei , Liu Yun‐Lin 
Published: July 2020

AbstractWe have developed a palladium‐catalyzed cross‐coupling reaction of isocyanides with α‐diazoacetates to form active ketenimines and following a 1,4‐diazabicyclo[2.2.2]octane (DABCO) catalyzed aza‐Mannich type reaction with various 2‐mercaptoimidazoles for the synthesis of 1,3‐bis(β‐aminoacrylate)‐substituted 2‐mercaptoimidazole derivatives with structural diversity. In addition, the use of 1H‐benzo[d]imidazol‐2‐ol as the reaction partner also allowed the formation of 1,3‐bis(β‐aminoacrylate)‐substituted 2‐benzimidazolinone derivatives with moderate yields (34–52%). In the aza‐Mannich reaction, the regioselective N‐attack rather than S‐attack or O‐attack at the electrophilic central carbon of ketenimines was observed. This tandem sequence is efficient since two C=C and two C−N bonds are consecutively created in one‐pot.magnified image
A Macromolecule Reversing Antibiotic Resistance Phenotype and Repurposing Drugs as Potent Antibiotics
Authors: Ding Xin , Yang Chuan , Moreira Wilfried , Yuan Peiyan , Periaswamy Balamurugan , de Sessions Paola Florez , Zhao Huimin , Tan Jeremy , Lee Ashlynn , Ong Kai Xun , Park Nathaniel , Liang Zhen Chang , Hedrick James L. , Yang Yi Yan 
Published: July 2020

AbstractIn order to mitigate antibiotic resistance, a new strategy to increase antibiotic potency and reverse drug resistance is needed. Herein, the translocation mechanism of an antimicrobial guanidinium‐functionalized polycarbonate is leveraged in combination with traditional antibiotics to afford a potent treatment for drug‐resistant bacteria. Particularly, this polymer–antibiotic combination approach reverses rifampicin resistance phenotype in Acinetobacter baumannii demonstrating a 2.5 × 105‐fold reduction in minimum inhibitory concentration (MIC) and a 4096‐fold reduction in minimum bactericidal concentration (MBC). This approach also enables the repurposing of auranofin as an antibiotic against multidrug‐resistant (MDR) Gram‐negative bacteria with a 512‐fold MIC and 128‐fold MBC reduction, respectively. Finally, the in vivo efficacy of polymer–rifampicin combination is demonstrated in a MDR bacteremia mouse model. This combination approach lays foundational ground rules for a new class of antibiotic adjuvants capable of reversing drug resistance phenotype and repurposing drugs against MDR Gram‐negative bacteria.
Synthesis of Thiol‐Containing Oligopeptides via Tandem Activation of γ‐Thiolactones by Silver‐DABCO Pair
Authors: Jiang Sheng‐Yuan , Hsieh Wen‐Tsai , Chen Wei‐Shuo , Liao Jia‐Shiang , Chiang Po‐Yu , Lin Yuya A. 
Published: July 2020

AbstractA method involving tandem activation of γ‐thiolactone by silver‐DABCO pair has been developed to enable successful amidation of homocysteine thiolactone by various amino acid residues and dipeptides with yields up to 95%. The introduction of thiol functionality to peptides directly using cysteine or homocysteine would require the protection of the reactive sulfhydryl groups and deprotection at a later stage of the synthesis. The γ‐thiolactone chemistry presented herein shows that it could serve as a masked and activatable reaction handle to prepare a range of thiol‐containing peptides in a more atom‐economical way. The resulting thiol‐containing peptides could facilitate late‐stage functionalization and structural diversification of functional or bioactive peptides. The silver(I) ion was found to be essential for the activation of the γ‐thiolactone, poor reactions were observed otherwise. A tentative mechanism for the silver‐DABCO promoted γ‐thiolactone aminolysis was proposed and supported by the evidence from thermal desorption electrospray ionization mass spectrometry.
Effect of injection molding on structure and properties of poly(styrene‐ethylene‐butylene‐styrene) and its nanocomposite with functionalized montmorillonite
Authors: Li Xiaoyan , Yu Hui , Kang Xiong , Chen Gang , Zhu Ming , Xu Jianjun 
Published: July 2020

AbstractIn this paper, the effects of injection molding on structure and properties of poly(styrene‐ethylene‐butylene‐styrene) (SEBS) and its nanocomposite with a functionalized montmorillonite (FMMT) were illustrated by comparison with the results of hot pressing. The injection‐molded SEBS and its FMMT nanocomposite have a skin‐core morphology with FMMT platelets more preferentially aligned along the sample plane, while hot‐pressed samples not. The injection‐molded samples also have a dense structure, and a less extent of microphase separation. In the injection molding process, the high shear flow coupled with solidification in presence of temperature gradient and high pressure in the closed cavity greatly affect the morphology and structure of the SEBS and its nanocomposites. The results also indicate attractive interaction between the soft segments of SEBS and the long alkyl silane chain grafted to FMMT, which allows FMMT to form a macroscopic network structure after the high‐speed and high‐pressure injection molding. The SEBS/FMMT‐injected nanocomposite have the highest tensile strength and the best corrosion resistance, which can be attributed to the dense skin‐core structure, stronger SEBS/FMMT interaction and the preferentially aligned FMMT platelets.
Time series of optical spectra of Nova V659 Sct
Authors: Jack Dennis , Schröder Klaus‐Peter , Eenens Philippe , Wolter Uwe , González‐Pérez José Nicolás , Schmitt Jürgen H. M. M. , Hauschildt Peter H. 
Published: July 2020

AbstractWith our robotic 1.2 m TIGRE telescope, we were able to obtain eight optical spectra with intermediate resolution (R ≈ 20,000) of the Nova V659 Sct during different phases of its outburst. We present a list of the lines found in the Nova spectra. The most common features are H I, O I, Na I, Fe II, and Ca II. Studying the spectral evolution of the strong features, we found that the absorption features move to higher expansion velocities before disappearing, and the emission features show (different) asymmetries. Because of the intermediate spectral resolution, we identified and analyzed the interstellar medium absorption features present in the spectra. We detected atomic absorption features of Na I and Ca II. The sodium D lines show more complex substructures with three main absorption features at a velocity of around −10, 30, and 85 km s−1. We identified several diffuse interstellar bands (DIBs) in the Nova V659 Sct spectra and determined their velocities and equivalent widths.
Bisphenols and phthalates: Plastic chemical exposures can contribute to adverse cardiovascular health outcomes
Authors: Ramadan Manelle , Cooper Blake , Posnack Nikki Gillum 
Published: July 2020

AbstractPhthalates and bisphenols are high production volume chemicals that are used in the manufacturing of consumer and medical products. Given the ubiquity of bisphenol and phthalate chemicals in the environment, biomonitoring studies routinely detect these chemicals in 75–90% of the general population. Accumulating evidence suggests that such chemical exposures may influence human health outcomes, including cardiovascular health. These associations are particularly worrisome for sensitive populations, including fetal, infant and pediatric groups—with underdeveloped metabolic capabilities and developing organ systems. In the presented article, we aimed to review the literature on environmental and clinical exposures to bisphenols and phthalates, highlight experimental work that suggests that these chemicals may exert a negative influence on cardiovascular health, and emphasize areas of concern that relate to vulnerable pediatric groups. Gaps in our current knowledge are also discussed, so that future endeavors may resolve the relationship between chemical exposures and the impact on pediatric cardiovascular physiology.
Stakeholder engagement in a sustainable sales and operations planning process
Authors: Roscoe Samuel , Subramanian Nachiappan , Prifti Romina , Wu Lin 
Published: July 2020

AbstractThe purpose of this paper is to understand how companies can transition to a sustainable sales and operations planning process to improve economic, environmental, and social performance. Data are collected from a survey of 120 managers in China's manufacturing sector and analyzed using partial least square‐based structural equation modeling. Drawing on life cycle theory and stakeholder theory, we argue that the conventional sales and operations planning (S&OP) process is internally focused and myopic, which over time leads to path dependencies and structural inertia. We find that firms can break free from this structural inertia by engaging external stakeholder groups that challenge the status quo and prompt organizational change. The paper contributes to theory by combining the key tenets of life cycle theory and stakeholder theory to explain how companies can transition to a sustainable S&OP process.
Promising insights into the kosmotropic effect of magnetic nanoparticles on proteins: The pivotal role of protein corona formation
Authors: Fattah Reza , Rashedi Hamid , Yazdian Fatemeh , Mousavi Seyed Babak , Fazeli Ahmad 
Published: July 2020

AbstractIncreasing concerns about biosafety of nanoparticles (NPs) has raised the need for detailed knowledge of NP interactions with biological molecules especially proteins. Herein, the concentration‐dependent effect of magnetic NPs (MNPs) on bovine serum albumin and hen egg white lysozyme was explored. The X‐ray diffraction patterns, zeta potential, and dynamic light scattering measurements together with scanning electron microscopy images were employed to characterize MNPs synthesized through coprecipitation method. Then, we studied the behavior of two model proteins with different surface charges and structural properties on interaction with Fe3O4. A thorough investigation of protein–MNP interaction by the help of intrinsic fluorescence at different experimental conditions revealed that affinity of proteins for MNPs is strongly affected by the similarity of protein and MNP surface charges. MNPs exerted structure‐making kosmotropic effect on both proteins under a concentration threshold; however, binding strength was found to determine the extent of stabilizing effect as well as magnitude of the concentration threshold. Circular dichroism spectra showed that proteins with less resistance to conformational deformations are more prone to secondary structure changes upon adsorption on MNPs. By screening thermal aggregation of proteins in the presence of Fe3O4, it was also found that like chemical stability, thermal stability is influenced to a higher extent in more strongly bound proteins. Overall, this report not only provides an integrated picture of protein–MNP interaction but also sheds light on the molecular mechanism underling this process.
Raman‐based dynamic feeding strategies using real‐time glucose concentration monitoring system during adalimumab producing CHO cell cultivation
Authors: Domján Júlia , Fricska Annamária , Madarász Lajos , Gyürkés Martin , Köte Ákos , Farkas Attila , Vass Panna , Fehér Csaba , Horváth Balázs , Könczöl Kálmán , Pataki Hajnalka , Nagy Zsombor Kristóf , Marosi György János , Hirsch Edit 
Published: July 2020

AbstractThe use of Process Analytical Technology tools coupled with chemometrics has been shown great potential for better understanding and control of mammalian cell cultivations through real‐time process monitoring. In‐line Raman spectroscopy was utilized to determine the glucose concentration of the complex bioreactor culture medium ensuring real‐time information for our process control system. This work demonstrates a simple and fast method to achieve a robust partial least squares calibration model under laboratory conditions in an early phase of the development utilizing shake flask and bioreactor cultures. Two types of dynamic feeding strategies were accomplished where the multi‐component feed medium additions were controlled manually and automatically based on the Raman monitored glucose concentration. The impact of these dynamic feedings was also investigated and compared to the traditional bolus feeding strategy on cellular metabolism, cell growth, productivity, and binding activity of the antibody product. Both manual and automated dynamic feeding strategies were successfully applied to maintain the glucose concentration within a narrower and lower concentration range. Thus, besides glucose, the glutamate was also limited at low level leading to reduced production of inhibitory metabolites, such as lactate and ammonia. Consequently, these feeding control strategies enabled to provide beneficial cultivation environment for the cells. In both experiments, higher cell growth and prolonged viable cell cultivation were achieved which in turn led to increased antibody product concentration compared to the reference bolus feeding cultivation.
Gene signature‐based prediction of triple‐negative breast cancer patient response to Neoadjuvant chemotherapy
Authors: Zhao Yanding , Schaafsma Evelien , Cheng Chao 
Published: July 2020

AbstractNeoadjuvant chemotherapy is the current standard of care for large, advanced, and/or inoperable tumors, including triple‐negative breast cancer. Although the clinical benefits of neoadjuvant chemotherapy have been illustrated through numerous clinical trials, more than half of the patients do not experience therapeutic benefit and needlessly suffer from side effects. Currently, no clinically applicable biomarkers are available for predicting neoadjuvant chemotherapy response in triple‐negative breast cancer; the discovery of such a predictive biomarker or marker profile is an unmet need. In this study, we introduce a generic computational framework to calculate a response‐probability score (RPS), based on patient transcriptomic profiles, to predict their response to neoadjuvant chemotherapy. We first validated this framework in ER‐positive breast cancer patients and showed that it predicted neoadjuvant chemotherapy response with equal performance to several clinically used gene signatures, including Oncotype DX and MammaPrint. Then, we applied this framework to triple‐negative breast cancer data and, for each patient, we calculated a response probability score (TNBC‐RPS). Our results indicate that the TNBC‐RPS achieved the highest accuracy for predicting neoadjuvant chemotherapy response compared to previously proposed 143 gene signatures. When combined with additional clinical factors, the TNBC‐RPS achieved a high prediction accuracy for triple‐negative breast cancer patients, which was comparable to the prediction accuracy of Oncotype DX and MammaPrint in ER‐positive patients. In conclusion, the TNBC‐RPS accurately predicts neoadjuvant chemotherapy response in triple‐negative breast cancer patients and has the potential to be clinically used to aid physicians in stratifying patients for more effective neoadjuvant chemotherapy.
A Modified Technique of Tacking Acellular Dermal Matrix to Increase Keratinized Mucosa Around Dental Implants as an Alternative to a Free Gingival Graft: A Case Report
Authors: Shi Ye , Segelnick Stuart L. , El Chaar Edgard S. 
Published: July 2020

IntroductionFree autogenous graft was the gold standard to increase the keratinized mucosa (KM) and vestibular depth. The major downfall of this technique is the postoperative morbidity at the donor site. The purpose of this case report is to demonstrate a modified technique using acellular dermal matrix (ADM) to increase the KM around implants to achieve faster healing with less postoperative morbidity.Case PresentationPatient presented with inadequate keratinized tissue band and shallow vestibule at submerged implant sites bilaterally. Initially, surgical procedure of vestibuloplasty in conjunction with free gingival graft (FGG) was performed at one side. However, patient opted for the allograft as a substitute for the other side due to the postoperative discomfort from palatal donor site. On the left side, the FGG procedure was performed in a conventional way stabilizing with sutures. On the right side, the ADM was stabilized with tacks only at recipient site and left exposed. The new vestibule was established and stabilized with tacks. A significant gain of KM and vestibule depth was observed at the site of using ADM when compared with baseline. For the site of using FGG, KM was increased. However, the vestibule was rebounded compared with the site of using ADM with tacks.ConclusionsThe use of ADM stabilized with tacks is a predictable procedure that can increase KM and establish stable vestibule around dental implants. It can lead to less chair time, faster healing, and reduced postoperative morbidity compared with autogenous soft tissue graft.
Destigmatising the stigma: Understanding the impact of message framing on Chinese consumers' guilt and attitude associated with overspending behaviour
Authors: Fan Wuqiu , Zhong Hanchun , Zhu Anding 
Published: July 2020

AbstractOverspending has been a largely stigmatised consumer behaviour in traditional Chinese culture. However, social and economic development in recent decades has induced the rise of Chinese consumerism and changes in public attitudes towards overspending. Focusing on overspending stigmas Gouwukuang (GWK) and Duoshoudang (DSD) and stigma‐relevant attitudes, the present study investigates the effect of perceived stigma on consumers' attitude towards overspending through the mediating effect of anticipated consumer guilt. The moderating role of message framing in this relationship is also examined. Results of two analyses indicate that (a) between the two stigmas, DSD is less stigmatising and preferred in comparison to GWK in social interaction and self‐identification; (b) participants' perception of the stigma associated with overspending predicts their anticipation of guilt associated with this behaviour, which in turn predicts negative attitude towards overspending; (c) message framing moderates the relationship between perceived stigma and anticipated guilt, and hence facilitates destigmatisation of the traditionally stigmatised behaviour of overspending. Theoretical and practical implications of these findings are discussed.