bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective study of photodynamic therapy for pulsed dye laser‐resistant port‐wine stains
Authors: Han Yue , Ying Hanru , Zhang Xiaolin , Yu Wenxin , Cen Qingqing , Chen Xuanfeng , Qiu Yajing , Chen Hui , Jin Yunbo , Ma Gang , Lin Xiaoxi 
Published: February 2020

AbstractPulsed dye laser‐resistant port‐wine stains present a therapeutic challenge. The aim of this study was to evaluate the efficacy and safety of photodynamic therapy for treating these lesions. A total of 67 patients with pulsed dye laser‐resistant cervicofacial port‐wine stains were retrospectively assessed after undergoing photodynamic therapy mediated with a combination of hemoporfin and 532‐nm light. For objective evaluation of photodynamic therapy efficacy, first, the colorimetric changes in the port‐wine stain lesions were evaluated according to the L*a*b* color coordinate system, then the values of color changes (ΔE) and blanching rate were calculated. For subjective evaluation of improvement, photographs taken before and after photodynamic therapy were evaluated by three independent assessors blindly. Patient satisfaction was also used as a factor in the subjective evaluation. Adverse events were recorded after treatment. The median ΔE decreased significantly from the pretreatment value of 13.42 to 9.90 at the 2‐month follow up (P < 0.001). The median blanching rate of port‐wine stains was 28.04% after an average of 1.21 sessions of photodynamic therapy. Based on the overall visual assessment, 46.2% patients showed excellent or good levels of improvement (>50% color blanching). Adverse events were minimal, transient and self‐limiting. In conclusion, photodynamic therapy serves as an alternative means to treat pulsed dye laser‐resistant port‐wine stains.
Nationwide prevalence of Torque teno sus virus 1 and k2a in pig populations in Japan
Authors: Furukawa Ayaka , Mitarai Sumire , Takagi Mitsuhiro , Yoshida Yuuhei , Ozawa Makoto , Taneno Akira , Deguchi Eisaburo 
Published: February 2020

AbstractBecause broad genetic diversity has recently been detected in Torque teno sus viruses (TTSuV1 and TTSuVk2), the viral genome detection method needs to be improved to understand the prevalence of these viruses. Here, we established single PCR‐based detection methods for the TTSuV1 and TTSuVk2a genomes with newly designed primer pairs and applied them to investigate the prevalence of TTSuV1 and TTSuVk2a in Japanese pig populations. The results revealed that 98.2% and 81.7% of the pig farms tested positive for the TTSuV1 and TTSuVk2a genomes, respectively, indicating that both TTSuV1 and TTSuVk2a are widespread in Japan.
An overview of siderophore biosynthesis among fluorescent Pseudomonads and new insights into their complex cellular organization
Authors: Schalk Isabelle J. , Rigouin Coraline , Godet Julien 
Published: February 2020

SummarySiderophores are iron‐chelating molecules produced by bacteria to access iron, a key nutrient. These compounds have highly diverse chemical structures, with various chelating groups. They are released by bacteria into their environment to scavenge iron and bring it back into the cells. The biosynthesis of siderophores requires complex enzymatic processes and expression of the enzymes involved is very finely regulated by iron availability and diverse transcriptional regulators. Recent data have also highlighted the organization of the enzymes involved in siderophore biosynthesis into siderosomes, multi‐enzymatic complexes involved in siderophore synthesis. An understanding of siderophore biosynthesis is of great importance, as these compounds have many potential biotechnological applications because of their metal‐chelating properties and their key role in bacterial growth and virulence. This review focuses on the biosynthesis of siderophores produced by fluorescent Pseudomonads, bacteria capable of colonizing a large variety of ecological niches. They are characterized by the production of chromopeptide siderophores, called pyoverdines, which give the typical green colour characteristic of fluorescent pseudomonad cultures. Secondary siderophores are also produced by these strains and can have highly diverse structures (such as pyochelins, pseudomonine, yersiniabactin, corrugatin, achromobactin and quinolobactin).
Age‐specific reference ranges of serum anti‐müllerian hormone in healthy women and its application in diagnosis of polycystic ovary syndrome: a population study
Authors: Li HWR , He Y‐L , Li R , Wong CYG , Sy B , Lam CW , Lam KSL , Peng H‐M , Mu S , Schooling M , Yeung WSB , Ho PC , Ng EHY 
Published: February 2020

ObjectiveTo establish the age‐specific centiles of serum anti‐müllerian hormone (AMH) levels in Chinese women, and to explore the use of multiples of median (MoM) AMH levels for the diagnosis of polycystic ovary syndrome (PCOS).DesignAn observational study.SettingUniversity‐affiliated hospitals and community clinics.PopulationWe included 3137 healthy women aged 20–44 years recruited prospectively or who had archived serum samples from previous research projects. Another validation cohort of 751 women with PCOS as well as ovulatory controls, which was a convenient sample of women attending for infertility or menstrual disorders, was also studied.MethodsThe serum samples were assayed for AMH by the automated Access AMH assay.Main outcome measuresAge‐specific reference ranges were constructed on the primary cohort with the Lambda‐Mu‐Sigma method. The MoM AMH of each subject in the validation cohort was calculated.ResultsCentile curves of serum AMH level against age were established. MoM AMH was significantly higher in women with PCOS than in controls (P < 0.05). The area under the ROC curve was 0.852 (95% confidence interval [CI] 0.825–0.877) (P < 0.0001) for discriminating women with PCOS from ovulatory controls by MoM AMH.ConclusionsWe established a set of year‐by‐year age‐specific reference ranges of serum AMH levels in Chinese women. The MoM AMH derived from this set of reference ranges is a promising tool to replace antral follicle count in the diagnosis of PCOS.Tweetable abstractA set of age‐specific reference ranges of AMH levels was established in Chinese women. Multiples of median AMH may be used to diagnose PCOS.
Detection of Inflicted Bruises by Alternate Light: Results of a Randomized Controlled Trial
Authors: Scafide Katherine N. , Sheridan Daniel J. , Downing Nancy R. , Hayat Matthew J. 
Published: February 2020

AbstractBruises are often difficult to detect on victims of violence, potentially impacting investigation and prosecution. The purpose of our randomized controlled trial was to measure the effectiveness of an alternate light source (ALS) within visible and long ultraviolet spectrums at improving bruise detection compared to white light over time. We also examined the effects of skin color, age, gender, localized fat, and injury mechanism on bruise detection. Participants included 157 healthy adults with balanced sampling across six skin color categories. Bruises were created under the controlled application of a paintball pellet and dropped weight to one upper and lower arm, respectively. Using a crossover design, both bruises were examined 21 times over 4 weeks. Ten different wavelength (350–535 nm) and filter (yellow, orange, red) combinations were used. Multilevel models were used to analyze 2903 examinations on both upper and lower arms. Results in multivariable models showed after controlling for other covariates 415 and 450 nm using a yellow filter had greater odds of detecting evidence of bruising than white light (Upper Arm: 415 nm: OR = 5.34, 95% CI: 4.35–6.56; 450 nm: OR = 4.08, 95% CI: 3.36–4.96). Under either light source, being female and having more localized fat had increased odds of detecting bruises created by the dropped weight (female: OR = 2.96, 95% CI: 2.37–3.70; fat: OR = 1.21, 95% CI: 1.09–1.34). Our results support ALS as an appropriate tool to enhance concurrent physical assessment of bruises in the presence of known history of injury. Future development and evaluation of clinical practice guidelines for ALS application are needed.
The Importance of Blind Forensic Odontology Analyses
Authors: Shiroma Calvin Y. , Zuerlein Chelsey L. 
Published: February 2020

AbstractForensic odontology cases examined from 2012 to 2019 at the Defense POW/MIA Accounting Agency (DPAA) laboratory were reviewed. Five cases from World War II and the Korea War were selected. Three of the cases presented involve dental assemblages, which were built by previous analysts. Postmortem radiographic analyses at the DPAA laboratory of these cases were complicated by the use of an older version of a digital x‐ray program and the assumption that teeth placed in the parent bone (maxilla and mandible) did not fully articulate due to the presence of debris at their root apices. Conflicting mitochondrial DNA test results for the submitted teeth and previously believed to be parent bone indicated these elements were not from the same individual. The remaining two cases are examples of how knowledge of findings from other disciplines may sway an opinion and could possibly lead to the rendering of erroneous opinions by the forensic odontologist. Having knowledge of previous examinations or results from other scientists, disciplines, and lines of evidence may lead to a bias in findings or opinions. If not careful, even the best‐intended scientist may fall victim to a bias in their opinion/analysis. The forensic odontologist should perform all analysis in the blind, not knowing any information which may bias their opinion, and utilize current versions of digital x‐ray software available and their tools when performing their examinations.
Viability of thermal imaging in detecting nests of the invasive hornet Vespa velutina
Authors: Lioy Simone , Bianchi Ettore , Biglia Alessandro , Bessone Mattia , Laurino Daniela , Porporato Marco 
Published: February 2020

AbstractVespa velutina is an invasive hornet species that is colonising Europe, generating considerable impacts on honeybees, beekeeping and biodiversity. Control and early warning strategies for this species are mainly based on monitoring plans and procedures of nest detection and destruction. Technological tools (harmonic radar, radio‐telemetry) have been developed to increase the probabilities of nest detection in new outbreaks. Since hornets are able to regulate nest temperature, thermography may represent an additional technique that may be used, both alone or in support to other techniques.In this study, the viability of thermal imaging in detecting nests of V. velutina was evaluated in controlled conditions. The influence of different environmental and operative variables (time of the day, presence/absence of leaves covering the nest, distance between the nest and the operator) were tested on three nests detected during August 2018 in Italy. All the nests were detectable by thermal imaging, but environmental and operative variables affect their detectability. The temperature difference between the nests and the surrounding reaches its maximum before sunrise and without a tree canopy covering the nests. Although nests were visible in some cases from 30 m, the detectability was higher at shorter distances, even if this variable may also depend on infrared camera resolution. An increase in the environmental temperature also generates a decrease of nest detectability. Although some limitations could occur, these results show the applicability of thermography in detecting V. velutina nests before the beginning of the reproductive phase, and consequently its potentiality in control strategies.
HR analytics: The onto‐epistemology and politics of metricised HRM
Authors: Greasley Kay , Thomas Pete 
Published: February 2020

AbstractThe development of HR analytics, the growing dominance of positivistic approaches in academic HRM, and the increasing influence of evidence‐based approaches on HR represent a convergence of contextual factors that have the potential to influence HR practice significantly. In this context, we examine how the HR analytics “project” may unfold base on a reflective analysis of a number of data‐rich well‐being projects and empirical evaluations. We focus on the ways in which participants may become enrolled and mobilised in such projects and the implications this has for perceived value and effects of “data” generated by HR analytics. In particular, we draw attention to the social, political, and onto‐epistemological processes of the analytics project and draw conclusions about the way in which the analytics project may influence professional practice.
MicroRNA‐153‐3p regulates cell proliferation and cisplatin resistance via Nrf‐2 in esophageal squamous cell carcinoma
Authors: Zuo Jing , Zhao Mei , Fan Zhisong , Liu Bowei , Wang Yudong , Li Yuehong , Lv Ping , Xing Lingxiao , Zhang Xianghong , Shen Haitao 
Published: February 2020

BackgroundOur recent studies have indicated that miR‐153‐3p is downregulated in the esophageal squamous cell carcinoma (ESCC) cell lines and tissues. Upregulation of miR‐153‐3p was found to inhibit migration and invasion of ESCC cells. However, whether miR‐153‐3p regulates the cisplatin sensitivity in ESCC cells remains unclear. In this study, we explored whether and how miR‐153‐3p regulates the proliferation and confers cisplatin resistance in ESCC by targeting the Nrf‐2 protein.MethodsEca109 cell line was transfected with microRNA‐153‐3p mimics or Nrf‐2siRNA and cell proliferation and cisplatin resistance were studied. A dual‐luciferase reporter assay was performed on Eca109 cells cotransfected with the wild‐type/mutant 3′UTR sequences of Nrf‐2 and control or microRNA‐153‐3p mimics. We determined the correlation between microRNA‐153‐3p and Nrf‐2 expression in human ESCC samples and explored the effect of Nrf‐2 in the overall survival rate of ESCC patients.ResultsMiR‐153‐3p significantly suppressed cell proliferation and increased the sensitivity of Eca‐109 cells to cisplatin. MiR‐153‐3p showed a negative correlation with Nrf‐2 in human esophageal carcinoma tissues. MiR‐153‐3p suppressed the expression of Nrf‐2 via binding to its 3′‐UTR region. Furthermore, inhibition of Nrf‐2 also decreased cell proliferation and increased the sensitivity of Eca109 cells to cisplatin. High expression of Nrf‐2 in human ESCC samples was associated with poor overall survival of ESCC patients.ConclusionMiR‐153‐3p inhibits cell proliferation and confers cisplatin resistance by downregulating Nrf‐2 expression in Eca‐109 cells. Thus, miR‐153‐3p/Nrf‐2 may play an important role in conferring cisplatin resistance in ESCC. Nrf‐2 appears to be a promising therapeutic target for ESCC.
Do Shareholders Assess Managers' Use of Accruals to Manage Earnings as a Negative Signal of Trustworthiness Even When Its Outcome Serves Shareholders' Interests?*
Authors: Hewitt Max , Hodge Frank D. , Pratt Jamie H. 
Published: February 2020

ABSTRACTWe examine how shareholders' trust in managers is affected by (i) the outcome of earnings management (inconsistent vs. consistent with shareholders' interests) and (ii) the method of earnings management (accruals vs. real methods). Using a controlled experiment, we predict and find that trust is impaired when the outcome of earnings management suggests that managers have put their interests above shareholders' interests and/or when the method of earnings management suggests that managers misreported the firm's economic performance. We argue that shareholders assess managers putting their interests above shareholders' interests as a signal of untrustworthiness because it involves a transfer of the firm's resources away from shareholders to managers. We argue that shareholders also assess managers' use of accruals to manage earnings as a signal of untrustworthiness because, in this instance, managers misreport the firm's economic performance. Finally, we show that trust mediates the combined effects of the outcome of earnings management and the method of earnings management on investment decisions. Our study incrementally contributes to the literature by highlighting the adverse implications of managers' use of accruals to manage earnings even when its outcome serves shareholders' interests.
Pain Severity and Alcohol Use Among Daily Tobacco Cigarette Smokers
Authors: LaRowe Lisa R. , Powers Jessica M. , Paladino Michael B. , Ditre Joseph W. 
Published: February 2020

Background and ObjectivesPain is associated with hazardous alcohol use. Drinkers have reported using alcohol for pain‐coping, and negative affect may be a key mechanism in pain‐induced motivation to drink. However, no previous study has examined pain severity in relation to alcohol consumption, dependence, and alcohol‐related consequences. Moreover, no studies have examined pain‐alcohol interrelations among tobacco cigarette smokers. These secondary analyses tested the hypotheses that greater past 4‐week pain severity would be positively associated with indices of hazardous drinking (ie, quantity/frequency, harmful use, and dependence), and that the current pain intensity would be positively/indirectly associated with the urge to drink via negative affect.MethodsParticipants included 225 daily smokers (43% female; MCPD = 22) who completed the baseline session for a larger experimental study.ResultsEvery one‐point increase in pain severity was associated with a 47% increased likelihood of hazardous drinking, and pain severity was positively associated with quantity/frequency of alcohol consumption, harmful patterns of drinking, and alcohol dependence level (Ps < .05). Pain intensity was indirectly associated with urge to drink via negative affect (P < .05).ConclusionsThese findings provide initial evidence that smokers with greater pain severity may also report hazardous patterns of alcohol use.Scientific SignificanceThis is the first study to demonstrate that past 4‐week pain severity may be one factor that maintains three conceptually distinct patterns of hazardous drinking among smokers. The current results also provide the first evidence that greater pain intensity may be associated with an increased urge to drink alcohol, via negative affect. (Am J Addict 2020;29:134–140)
High‐fat diet pre‐conditioning improves microvascular remodelling during regeneration of ischaemic mouse skeletal muscle
Authors: Nwadozi Emmanuel , Rudnicki Martina , De Ciantis Matthew , Milkovich Stephanie , Pulbere Alexandru , Roudier Emilie , Birot Olivier , Gustafsson Thomas , Ellis Christopher G. , Haas Tara L. 
Published: February 2020

AbstractAimCritical limb ischaemia (CLI) is characterized by inadequate angiogenesis, arteriolar remodelling and chronic myopathy, which are most severe in type 2 diabetic patients. Hypertriglyceridaemia, commonly observed in these patients, compromises macrovascular function. However, the effects of high‐fat diet‐induced increases in circulating lipids on microvascular remodelling are not established. Here, we investigated if high‐fat diet would mimic the detrimental effect of type 2 diabetes on post‐ischaemia vascular remodelling and muscle regeneration, using a mouse model of hindlimb ischaemia.MethodsMale C57Bl6/J mice were fed with normal or high‐fat diets for 8 weeks prior to unilateral femoral artery ligation. Laser doppler imaging was used to assess limb perfusion recovery. Vascular recovery, inflammation, myofibre regeneration and fibrosis were assessed at 4 or 14 days post‐ligation by histology and RNA analyses. Capillary‐level haemodynamics were assessed by intravital microscopy of control and regenerating muscles 14 days post‐ligation.ResultsHigh‐fat diet increased muscle succinate dehydrogenase activity and capillary‐level oxygen supply. At 4 days post‐ligation, no diet differences were detected in muscle damage, inflammatory infiltration or capillary activation. At 14 days post‐ligation, high fat‐fed mice displayed accelerated limb blood flow recovery, elevated capillary and arteriole densities as well as greater red blood cell supply rates and capillary‐level oxygen supply. Regenerating muscles from high fat‐fed mice displayed lower interstitial fat and collagen deposition.ConclusionThe muscle‐level adaptations to high‐fat diet improved multiple aspects of muscle recovery in response to ischaemia and did not recapitulate the worse outcomes seen in diabetic CLI patients.
Real‐world data on safety and efficacy of venetoclax‐based regimens in relapsed/refractory t(11;14) multiple myeloma
Authors: Basali Diana , Chakraborty Rajshekhar , Rybicki Lisa , Rosko Nathaniel , Reed Janice , Karam Maryann , Schlueter Kristen , Dysert Hayley , Kalaycio Matt , Valent Jason 
Published: February 2020

SummaryThe treatment for relapsed/refractory multiple myeloma (RRMM) continues to be challenging despite recent therapeutic advancements. Venetoclax, an inhibitor of the anti‐apoptotic protein BCL‐2, is a promising agent, especially in patients harbouring t(11;14). Our objective was to review our experience with venetoclax‐based regimens at our institution. All ten RRMM patients treated with venetoclax were included and had a median of six prior lines of therapy. The overall response rate was 78% and one patient with cardiac amyloidosis and MM achieved a cardiac organ response. Haematologic toxicities requiring red blood cell and platelet transfusion and non‐haematologic toxicities, most commonly gastrointestinal upset, were observed.
Volumetric assessment of unaffected parenchyma and Wilms’ tumours: analysis of response to chemotherapy and surgery using a semi‐automated segmentation algorithm in children with renal neoplasms
Authors: Rickard Mandy , Fernandez Nicolas , Blais Anne‐Sophie , Shalabi Ahmed , Amirabadi Afsaneh , Traubici Jeffrey , Lee Wayne , Gleason Joseph , Brzezinski Jack , Lorenzo Armando J. 
Published: February 2020

ObjectiveTo present our proof of concept with semi‐automatic image recognition/segmentation technology for calculation of tumour/parenchyma volume.MethodsWe reviewed Wilms' tumours (WTs) between 2000 and 2018, capturing computed tomography images at baseline, after neoadjuvant chemotherapy (NaC) and postoperatively. Images were uploaded into MATLAB‐3‐D volumetric image processing software. The program was trained by two clinicians who supervised the demarcation of tumour and parenchyma, followed by automatic recognition and delineation of tumour margins on serial imaging, and differentiation from uninvolved renal parenchyma. Volume was automatically calculated for both.ResultsDuring the study period, 98 patients were identified. Of these, based on image quality and availability, 32 (38 affected moieties) were selected. Most patients (65%) were girls, diagnosed at age 50 ± 37 months of age. NaC was employed in 64% of patients. Surgical management included 27 radical and 11 partial nephrectomies. Automated volume assessment demonstrated objective response to NaC for unilateral and bilateral tumours (68 ± 20% and 53 ± 39%, respectively), as well as preservation on uninvolved parenchyma with partial nephrectomy (70 ± 46 cm3 at presentation to 57 ± 41 cm3 post‐surgery).ConclusionVolumetric analysis is feasible and allows objective assessment of tumour and parenchyma volume in response to chemotherapy and surgery. Our data show changes after therapy that may be otherwise difficult to quantify. Use of such technology may improve surgical planning and quantification of response to treatment, as well as serving as a tool to predict renal reserve and long‐term changes in renal function.