bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tantangan Konversi Bank Konvensional Menjadi Bank Syariah di Aceh Berdasarkan Qanun Lembaga Keuangan Syariah No 11 Tahun 2018
Authors: Rahmawati Rahmawati , Putriana Khairul 
Published: October 2020

<p><em>The presence of the Islamic Financial Institution Qanun No 11 </em><em>in </em><em>2018 is a special right for Aceh and has brought a breath of fresh air to the development of the Islamic banking industry in Aceh, a number of conventional banks in Aceh are required to convert to Islamic banks, The purpose of this study is to explain the procedure for accelerating the conversion of unconventional banks to Islamic banks in Aceh and to explain the challenges of banking institutions with the obligation to convert financial institutions in Aceh. The obligation to convert a conventional bank into a sharia bank is clearly as stipulated in article 6 points e and d, although the process of converting a conventional bank to a sharia bank is not found directly in the qanun, but every bank that does the conversion must refer to BI regulations namely PBI No. 11 / 15 / PBI-2009, this is as explained in article 12 "before carrying out business activities, LKS must have a business license in accordance with the provisions of the legislation".</em></p><br /><p> </p>
TEACHER’S STRATEGIES TO CREATE A CONDUCIVE LEARNING ENVIRONMENT IN THE RON CLARK STORY MOVIE
Authors: Yusuf Adi , Pattisahusiwa Ernawati 
Published: October 2020

In learning process, a good teacher indeed needs a strategy to create a conducive learning environment in order that it runs smoothly. The Ron Clark Story Movie depicts how a teacher uses various strategies to create a conducive classroom environment so that the learning process can run well. The purposes of this research are to identify what strategies used by the teacher, Mr. Clark, to create a conducive learning environment in The Ron Clark Story Movie and to describe how the strategies are implemented by the teacher to create a condusive learning environment in the Movie. This study was designed qualitatively. The data of this study were scenes on the teacher’s strategies to create a conducive learning environment in the movie. The source of data in this study was a movie entitled The Ron Clark Story.It was found that Mr. Clark used 5 types of teacher’s strategies to create a conducive classroom environment: physical design of the classroom, rules and routines, relationship, engaging and motivation, and discipline. Each of the strategies has several classifications. By applying these strategies, the students of Mr. Clark finally succeeded in passing the exam with satisfactory grades.
Matrix Acidizing: A Laboratory and Field Investigation of Sludge Formation and Removal of Oil-Based Drilling Mud Filter Cake
Authors: Almubarak Tariq , AlKhaldi Mohammed , Ng Jun Hong , Nasr-El-Din Hisham A. 
Published: October 2020

Summary
Hydrochloric and organic acids have been extensively used to enhance well productivity or injectivity in tight carbonate formations (10 to 50 md). The use of these acids, however, can cause instances of complete production loss. This is especially common due to incompatibilities of the acidizing fluid and oil, which can lead to the formation of acid/oil emulsions and sludge formation. Consequently, it is necessary to properly identify and remove such emulsions or precipitations without causing any further damage.
Compatibility studies were conducted using representative crude samples and hydrochloric acid (HCl). The experiments were conducted at various temperatures up to 240°F using high-pressure/high-temperature (HP/HT) aging cells for both live and spent acid samples, in which some of the experiments included an antisludge, an iron-control agent, and a demulsifier. In addition, another set of experiments was performed in the presence of ferric ions (Fe3+). The total iron concentration in these experiments was varied between 0 and1,000 ppm. The results showed that commonly used acid systems were not compatible with representative oil field samples. The amount of sludge formed and the stability of formed emulsions increased significantly in the presence of ferric ions and was more severe in the presence of hydrogen sulfide (H2S).
Using a field case, this paper will cover the methodology used to ascertain the source of formation damage from acidizing, study the different factors that influence the formation of acid/oil emulsion and sludge formation mechanism, and show how they can be removed. In this example, acid/oil emulsions, sludge formation, and improper drilling mud filter-cake removal were the reasons behind the production loss. However, the methodology can be expanded to cater the many acidizing failure cases faced in the industry worldwide.
A Milroy Disease Family Caused by FLT4 Gene Mutation of c.2774 T&gt;A with Phenotypes Heterogeneity
Authors: Sui Yu , Lu Yongping , Lin Meina , Ni Xiang , Chen Xinren , Li Huan , Jiang Miao 
Published: October 2020

Abstract
Background: Milroy disease is a rare, autosomal dominant disorder. Mutations of FLT4 (Fms Related Tyrosine Kinase 4) gene impaired tyrosine kinase signaling, and further cause symptoms of Milroy disease. In this research, we found a large Chinese MD family with phenotype heterogeneities. And we conducted Next Generation Sequencing analysis to explore possible genetic causative factors might be related to clinical heterogeneities among family members.Methods: Sanger sequencing was conducted on the 17-26 exons of FLT4 (NM_182925.4) gene. Primers were as follows: Froward: 5' CTTCATCAGCGTCGAGTGG 3'; Reverse: 5' ATTATGGGCGGGTTCCTT 3'; Next-generation sequencing was conducted to explore pathogenic mutation might lead to phenotype heterogeneities. Then we conducted Sanger sequencing of the possible related genes. The GIMAP7 gene amplification primers as follows: Forward primer: 5’ ACCACCTGCAAGGAAATCAGCCGCT3’; Reverse primer: 5’GTTAGAGAAATACCTCCTTCCCCTT3’. The amplification system for two genes are as follows: 2×Biotech Power PCR Mix: 10µl; forward primer: 0.8µl (10µM); reverse primer: 0.8µl (10µM); DNA template: 1µl (50ng/µl); ddH20: 13.4µl. The effects of the mutations on the gene functions were evaluated with mutation taster and/or SIFT, PolyPhen.Results: A heterozygous substitution mutation was detected in all patients (FLT4 gene: c.2774 T>A, p.V925E). Meanwhile, a G deletion (c.826delG, p.Val276Phefs*29) of GIMAP7 gene was detected in all patients but two patients with phenotype heterogeneities (I1, and II1). Both the two mutations were predicted to be pathogenic.Conclusions: In this report, we described a large Milroy disease family caused by a missense mutation of the FLT4 gene (c.2774 T>A, p.V925E). Meanwhile, a frame-shift mutation (c.826delG, p.Val276Phefs*29) of GIMAP7 gene might be related to the clinical phenotype heterogeneities of the family.
Intraoperative Neurovascular Bundle Preservation With Hyaluronic Acid During Radical Brachytherapy for Localized Prostate Cancer: Technique
Authors: Prada Pedro J. , Cardenal J. , Blanco A. García , Ferri M. , Arrojo E. , Anchuelo J. , Cerio I. Diaz de , Sierrasesumaga N. , Lastra P. , Fernández A. , Vázquez A. , Arrebola S. Ruiz 
Published: October 2020

Abstract
Background: To evaluate the reduction, the absorbed dose delivered to the neurovascular bundle (NB) in patients with localized prostate cancer treated with only HDR brachytherapy and neurovascular bundle protection with Hyaluronic acid (HA) on the side of the prostate to increase the distance from NB to the radioactive sources.Material and Methods: This is the first published report in the medical literature that study a new approach to decrease neurovascular bundle toxicity and improve quality of life for patients with prostate cancer treated with radical brachytherapy as monotherapy. Transperineal HA injection on the side of the prostate into the lateral aspect of the prostate fat was used to consistently displace several autonomic fibres and vessels the lateral wall of the prostate away from radiation sources.Results: When a protection in the form of a HA layer is placed, the reduction effect at the maximum dose is between 46% and 54% (calculated values), which means the method for protection is highly recommended. The values of the absorbed dose calculated in this project have been compared with the ones given by the treatment planning system. These calculated values are similar than the ones given by the treatment planning system (56±2).Conclusions: This newly created space decreases absorbed dose in the neurovascular bundle, calculated with the TPS and measuremed by microMOSFET due to the thickness of HA.
Facing the Unknown: Healthcare Workers’ Concerns, Attitudes and Burnout During the COVID-19 Pandemic - A Mixed Methods Study
Authors: Dopelt Keren , Bashkin Osnat , Davidovitch Nadav , Asna Noam 
Published: October 2020

Abstract
Background: Medical staff, who care for patients at their own risk, are on the frontlines of the fight against COVID-19. The aim of this study is to describe the feelings and experiences of medical staff working in hospitals during the coronavirus crisis.Methods: Data were collected as part of a mixed-methods study that included an online survey completed by 263 hospital staff members, as well as 10 semi-structured, in-depth interviews with doctors, nurses and medical technicians working on coronavirus wards.Results: The survey findings revealed that respondents expressed extremely high rates of concern for family members and at a national level, but that they were less apprehensive about their own health and safety. At the same time, burnout was lower than the rates of concern. Nurses displayed more apprehension and burnout compared to medical staff in other professional roles. The in-depth interviews reinforced and supplemented the survey findings and deepened our understanding of the feelings of medical staff directly involved in coronavirus patient care.Conclusions: The study’s findings revealed the main concerns of hospital staff during the coronavirus crisis and deepened our understanding of the issues that require systemic attention in order to strengthen the mental resilience of hospital staff, in particular those working on coronavirus wards. The steps required to continue coping with and fighting the virus include the development of a mental and emotional support network for medical staff, to safeguard them and their health as they care for patients, and to provide ongoing psychosocial support.
Clinical and Quality of Life Outcomes Among Ixekizumab -Treated Psoriasis Patients in a Real-World Setting: Results from a Single US Dermatology Referral Practice
Authors: Leonardi Craig , Tao Rei , Setayeshgar Solmaz , Wang Sisi , McMullen Suzanne , Burge Russel , Zhu Baojin , Malatestinic William N 
Published: October 2020

Abstract
Background: Psoriasis is a chronic immune-mediated inflammatory skin condition that has a significant negative impact on the physical, emotional, and psychosocial well-being of those affected. Ixekizumab (IXE) has demonstrated an early and high-level treatment response in the real-world setting. This study aimed to assess the rapidity and long-term disease severity and quality of life (QOL) outcomes among IXE-treated plaque psoriasis patients. Method: A retrospective cohort study was conducted at a single US dermatology referral center. Medical charts were reviewed for adult psoriasis patients starting IXE (index date) between March 22, 2016, and February 28, 2018. Disease severity and QOL data were abstracted up to one-year pre-IXE initiation and up to 35 months post-IXE initiation. Static Physician Global Assessment (sPGA), Body Surface Area (BSA), and Dermatology Life Quality Index (DLQI) were summarized at 1-month post-index and at 3-month intervals. Logistic regressions were performed to evaluate the 1-month response in relation to long-term sPGA, BSA, DLQI outcomes. Subgroup analysis were conducted to compare outcomes among biologic naïve and biologic experienced patients.Results: A total of 153 patients (median age at index: 47.7 years; 65.4% male; 93.5% Caucasian) were included in the study. Majority of patients (69%; n=106) were biologic experienced prior to IXE initiation. In the total study cohort, at 1-month post-index 58.8% of patients achieved sPGA (0,1), 55.9% achieved DLQI (0,1), and 66.9% achieved BSA≤1%. Patients with sPGA (0,1) at 1-month post-index had greater odds of remaining sPGA (0,1) and BSA≤1% at 24-month (sPGA 0,1: OR=10.1; 95% CI: 2.1-47.9; BSA≤1%: OR=13.3; 95% CI: 2.2-80.2). Among patients who achieved sPGA (0,1) at 1-month post-index, the proportion of patients with sPGA (0,1), DLQI (0,1), and BSA≤1% remained largely the same for the 24-month follow-up. Among biologic experienced and naïve patients, more than half achieved sPGA (0,1), DLQI (0,1), and BSA≤1% at 1-month after IXE initiation. Conclusion: This real-word study demonstrated that majority of patients initiating IXE achieved sPGA (0, 1), DLQI (0, 1) and BSA ≤1% targets within the first month of treatment and were able to maintain treatment response for up to 24 months independent of prior biologic exposure.
Spatiotemporal Variation and Risk Factors of Tuberculosis in Socio-Economic Development Unbalanced Region
Authors: wang li , Xu Chengdong , Hu Maogui , Qiao Jiajun , Chen Wei , Li Tao , Qian Songbo , Yan Mingtao 
Published: October 2020

Abstract
Background: Previous studies had indicated that the incidence of Tuberculosis (TB) was closed related to the regional aging population and socio-economic condition. However, spatio-temporal variation and risk determinants of TB in aging population and socio-economic development unbalanced region have been unclear.Methods: The data on TB registered cases and social-economic factors from 2009 to 2014 were collected for each district/county in the region with Beijing, Tianjin and Hebei province of China, which is consist of aging population and social-economic development disparity region. The Bayesian space–time hierarchy model was used to reveal the spatio-temporal variation of elderly TB incidence from 2009 to 2014, and GeoDetector was applied to measure the determinant power (q statistic) of elderly TB risk factors.Results: Elderly TB incidence present geographical spatial heterogeneity, they were higher in underdeveloped rural areas compared with that in urban areas. The hotspots of elderly TB incidence risk were mostly located in the northeastern and southern regions of the study region distant from metropolitan areas. Areas with low risk were mainly distributed in the Beijing-Tianjin metropolitan areas. Social-economic factors presented nonlinear influence on elderly TB incidence, the dominant factors were income of rural populations (q statistic = 0.20) and medical conditions (q statistic = 0.17). These factors presented nonlinearly interact with each other in influencing the elderly TB incidence; medical conditions and level of economic development showed the strongest relationship (q statistic = 0.54).Conclusions: These findings explain spatiotemporal variation and risk determinants of elderly TB incidence where there are social-economic development disparities. High-risk zones were mainly located in rural areas far from metropolitan centers. Medical conditions and economic development level were significantly association with elderly TB incidence, and they showed nonlinearly interact with each other in influencing the elderly TB incidence. Knowing this helps to optimize the allocation of health resources and to control the transmission of the TB epidemic in the aging population in this region.
Influence of GSTT1 and GSTP1 Polymorphisms on Type 2 Diabetes Mellitus and Diabetic Retinopathy Risk in The Chinese Population: A Case Control Study
Authors: Geng Xinqian , Zha Ling , Zhou Taicheng , Xiong Yuxin , Xu Fan , Xu Bo , Wang Feiying , Wang Xiaoling , Yang Ke , Tao Wenyu , Li Yiping , Yang Ying 
Published: October 2020

Abstract
Background: Studies have revealed the association of glutathione S-transferases (GSTM1 and GSTT1) deletion (null) polymorphism with the risks of developing type 2 diabetes mellitus (T2DM) and its complications. The present study aimed to investigate the relationship between GSTT1/ GSTP1 gene polymorphisms and the risks of T2DM and diabetic retinopathy (DR) in a Chinese population.Methods: A total of 336 subjects with T2DM and a defined ophthalmologic status were recruited from the Second People’s Hospital of Yunnan Province between June 2014 and October 2016. Seventy-two age-matched healthy controls were also enrolled. Physical examinations and laboratory tests were performed. The frequencies of GSTT1 and GSTP1 genotypes in all participants were determined by PCR and PCR-restriction fragment length polymorphisms (PCR–RFLP), respectively.Results: Compared with healthy controls, the GSTT1-null genotype was significantly more common in diabetic patients with or without DR (all P < 0.05). However, the frequency of the GSTP1 genotype (AA, GA, GG) was comparable between the two groups. Furthermore, neither the GSTP1 nor GSTT1 genetic polymorphism was associated with the development of DR. In the present study, the risk of developing T2DM was significantly higher in subjects carrying the combined heterozygous GSTP1 (AG) and null GSTT1 genotypes (OR=0.40, 95% CI=0.21-0.74, P=0.02).Conclusions: The deletion of the GSTT1 genotype was associated with a higher risk of developing T2DM, whether alone or in combination with GSTP1, indicating that the null genotype of GSTT1 may serve as a potential biomarker for T2DM in the Chinese population, which is helpful for clinicians to make more effective risk-based decisions.
Cell-type composition analysis of scRNA-seq data with deep convolution neural network
Authors: Ma He , Fang Zhihao , Liu Zongbin , Chen Yan 
Published: October 2020

Abstract
BackgroundWith the rapid development of single-cell RNA sequencing (scRNA-seq), more large-scale single-cell sequencing data has been generated. Due to the continuous increase of single-cell sequencing data, the analysis of cell-type composition from single-cell transcriptomics has also to face huge challenges. Since the emergence of scRNA-seq technology, the size of sequencing datasets has grown more than 1 million times in just over a decade. Meanwhile, as more gene markers are discovered, the data dimension of single-cell sequencing becomes higher. All of these put forward more stringent requirements on data dimensionality reduction and clustering algorithms. Under the constraints of practical factors such as occurrence of noise and dropouts and the limitation of overhead, it is also required an effective and effcient method that can obtain accurate analysis results in a very short time, and has a competitive algorithm stability.ResultsWe present scCAE, an effective and effcient method based on convolution autoencoder that can accurately and rapidly analyze cell-type composition from single-cell transcriptomics datasets. Our method achieved the best results in the data sets that simulate the cell differentiation process among existing methods, which achieved the ARI of 69.64% and 68.83% at 10 and 25 clusters tasks. And, in the case of different dropouts, our method also works well. When the sparsity level of data metric is 71%, scCAE can achieved the ARI of 45.29%, which is the highest of the existing methods. In terms of algorithm overhead, our method has also achieved good results by comparing with several existing methods. It takes less time than most methods and takes up much less memory than other algorithms based neural networks.ConclusionsOur method, scCAE, has more accurate and reasonable results in the analysis of cell-types composition. And, because of the design of imputer, it can deal with a large number of dropouts in the data matrix. Because of the structure of convolution network, scCAE has less time and space overhead than other deep-learning-based methods. Thus, we demonstrate that scCAE is a competitive method for analysis of cell-type composition from scRNA-seq data. We expect that our study can be a stepping stone for further prosperity of single-cell transcriptomics analysis.
Impact of High Body Mass Index on The Allograft Outcomes in Kidney Transplant Recipients with Pre-Sensitization to Human Leukocyte Antigen: A Retrospective Cohort Study
Authors: Park Yohan , Lee Hanbi , Ko Eun Jeong , Lee Sua , Ban Tae Hyun , Min Ji-Won , Yoon Hye-Eun , Oh Eun-Jee , Yang Chul Woo , Chung Byung Ha 
Published: October 2020

Abstract
Background The aim of this study was to investigate whether high body mass index (BMI) and pre-sensitization to human leukocyte antigen (HLA) in kidney transplant recipients (KTR) had a synergistic impact on the allograft outcomes.Methods From January 2010 to December 2018, 1,290 KTs were performed in Seoul St Mary's Hospital. Of these, 682 cases of ABO compatible KT were enrolled. They were divided into 4 groups (low BMI-non-sensitized, high BMI-non-sensitized, low BMI sensitized, high BMI-sensitized) according to the median BMI value (22.7 kg/m2) and HLA pre-sensitization status (HLA-DSA MFI >3,000). Short-term and long-term allograft outcomes were compared between the groups.Results The rate of late antibody mediated rejection tended to be the highest in the high BMI-sensitized group, and the decline in allograft function in the high BMI-sensitized group was higher than in the other 3 groups. Death-censored graft loss (DCGL) rates and the hazard ratio (HR) for DCGL were the highest in the high BMI-sensitized group (4/21 (19.0%), HR 4.648, P = 0.022) and a significant interaction was detected between high BMI and HLA pre-sensitization status (P value for interaction = 0.008). Conclusions Our results suggest that pre-sensitization to HLA and high BMI in KTRs might have a synergistic adverse impact on the allograft outcomes.
Reliability and Validity of a Free Oral Pre-exposure Prophylaxis (PrEP) Adherence Questionnaire Among Patients with Sexually Transmitted Infection and Without HIV Infection in Shanghai
Authors: Yu Xiaoyue , Xu Chen , Ni Yang , Chang Ruijie , Wang Huwen , Gong Ruijie , Wang Ying , Wang Suping , Cai Yong 
Published: October 2020

Abstract
Objective: In this study, we aimed to evaluate the validity and reliability of the free oral pre-exposure prophylaxis (PrEP) adherence questionnaire among patients with sexually transmitted infection who do not have HIV infection in Shanghai. Methods: We conducted a cross-sectional study among 816 patients from sexually transmitted infection (STI) clinics in Shanghai. The questionnaire included self-reported demographic characteristics, items on adherence to free oral pre-exposure prophylaxis (PrEP), and PrEP uptake behavior measurement. Item analysis was carried out by calculating the critical ratio and item-total correlations. Internal consistency and split-half reliability were measured to assess reliability. Content validity, construct validity, convergent validity and discriminant validity were measured to assess validity. We conducted logistic regression with receiver operating characteristic (ROC) curve analysis to assess the predictive value of the adherence questionnaire for PrEP uptake behavior. Results: All items were considered acceptable in the item analysis (P<0.05). The questionnaire had a Cronbach’s alpha of 0.757 and split-half reliability of 0.633. The scale-level content validity index (CVI) was 0.938 and the item-level CVI of each item ranged from 0.750 to 1. In exploratory factor analysis, we introduced a four-factor model accounting for 79.838% of the aggregate variance with all factors loading more than 0.4, which was validated in confirmatory factor analysis (c2=47.1, degrees of freedom=14, root mean square error of approximation=0.078). According to regression analysis, adding PrEP adherence questionnaire scores contributed to prediction of PrEP uptake behavior (P<0.001). The maximum area under the ROC curve was 0.778 (95% confidence interval: 0.739–0.817), corresponding to a cutoff score of 9.Conclusion: The PrEP adherence questionnaire generally has acceptable reliability and validity. This questionnaire can be used as a tool to evaluate PrEP adherence in patients with STI who do not have HIV infection.