bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three‐year clinical outcome in all‐comers with “silent” diabetes, prediabetes, or normoglycemia, treated with contemporary coronary drug‐eluting stents: From the BIO‐RESORT Silent Diabetes study
Authors: Ploumen Eline H. , Buiten Rosaly A. , Kok Marlies M. , Doggen Carine J.M. , van Houwelingen K. Gert , Stoel Martin G. , de Man Frits H.A.F. , Hartmann Marc , Zocca Paolo , Linssen Gerard C.M. , Doelman Cees , Kant Gert D. , von Birgelen Clemens 
Published: October 2019

AbstractBackgroundPatients with coronary disease may have unknown diabetes or prediabetes. We evaluated 3‐year outcomes after percutaneous coronary intervention (PCI) with contemporary drug‐eluting stents (DES) in patients with silent diabetes, prediabetes, and normoglycemia.MethodsAll BIO‐RESORT trial (NCT01674803) participants without known diabetes, enrolled at our center, were invited for oral glucose tolerance testing (OGTT) and measurements of fasting plasma glucose and glycated hemoglobin (HbA1c).ResultsOGTT detected silent diabetes in 68 (6.9%), prediabetes in 132 (13.4%), and normoglycemia in 788 (79.8%) of all 988 study participants. Follow‐up was available in 986 (99.8%) patients. The main endpoint target vessel failure (TVF: cardiac death, target vessel‐related myocardial infarction [MI], or target vessel revascularization) differed between groups (14.8, 9.9, and 5.6%; p = .002), driven by MI during the first 48 hr and by cardiac death (p < .001; p = .026). Between 48 hr and 3‐years, there was no significant between‐group difference in TVF, target vessel MI, and target vessel revascularization. Multivariable analysis demonstrated that silent diabetes was independently associated with TVF (adjusted HR: 2.52, 95%‐CI: 1.26–5.03). An alternative diagnostic approach—HbA1c and fasting plasma glucose—detected silent diabetes and prediabetes in 33 (3.3%) and 217 (22.0%) patients, and normoglycemia in 738 (74.7%); TVF rates were 12.1, 7.9, and 6.0% (p = .23).ConclusionIn patients without known diabetes, abnormal glucose metabolism by OGTT was independently associated with higher 3‐year TVF rates after PCI with contemporary DES. This difference was driven by periprocedural MI and cardiac death. After the first 48 hr, the rates of TVF, target vessel MI, and target vessel revascularization were low and did not differ significantly between metabolic groups.
15 Jahre Trialog in der Prozessanalytik
Authors: Rübberdt Kathrin 
Published: October 2019

AbstractProzessanalysentechnik als Forum für Anwender, Hersteller und Akademia gegründet. Heute ist er mindestens so wichtig wie damals, denn kaum ein Thema entwickelt sich angesichts von Digitalisierung und Prozessintegration so dynamisch wie die Prozessanalytik.
FILTECH 2019 – Weiter auf Erfolgskurs
Authors: Anlauf Harald 
Published: October 2019

AbstractDie FILTECH befindet sich ungebrochen auf Erfolgskurs und kann gegenüber 2018 mit erneut deutlich erweitertem Ausstellungs‐ und Vortragsangebot aufwarten. Nachdem die Fachmesse 2018 mit 380 Ausstellern und über 180 wissenschaftlichen Vorträgen auf dem parallel zur Messe stattfindenden Kongress 14.000 Besucher aus 76 Nationen begrüßen durfte, wird in diesem Jahr bei über 400 Ausstellern und mehr als 200 wissenschaftlichen Präsentationen mit einem mindestens vergleichbar guten Besucherergebnis gerechnet.
Simulationen in der Verfahrenstechnik
Authors:   CITplus
Published: October 2019

AbstractNumerische Simulation und Modellierung haben längst Einzug in die Entwicklungsprozesse der Verfahrenstechnik genommen, was auf die neuen Technologien und die zunehmende Digitalisierung der Prozessindustrie zurückzuführen ist. In den letzten Jahren gab es sowohl im Bereich einfacher Fließschema‐Simulationen als auch bei komplexen CFD‐Modellen enorme Fortschritte. Eine ganz spezielle Weiterentwicklung erhöht die Benutzerfreundlichkeit sogar so weit, dass Simulation auf höchstem Niveau für völlig unerfahrene Anwender möglich wird.
Prozesstaugliche, preiswerte Brennersteuerung
Authors: Kuchenmeister Reinhold 
Published: October 2019

AbstractDer Differenzdruck‐Durchflussmesser deltaflowC ist der weltweit wohl kleinste und schnellste multivariable Messumformer zur Massenstrommessung von Gasen. Er kann einen wichtigen Beitrag zur Steigerung der Brennereffizienz und damit zur Senkung von Energieverbrauch und CO2‐Ausstoß leisten.
Reibungslos
Authors: Plaga Daniel 
Published: October 2019

AbstractDie flexible und skalierbare HIQuad X von Hima ist eine Weiterentwicklung der HIQuad, die seit rund 30 Jahren über zehntausend Applikationen in aller Welt absichert. Das neue programmierbare Sicherheitssystem gliedert sich nahtlos in die Smart Safety Plattform des Schwetzinger Sicherheitsspezialisten ein.
Condensed desmin and actin cytoskeletal communication in lipid droplets
Authors: Miyasaka Yoshiya , Murakami Keigo , Ito Koji , Kumaki Jiro , Makabe Koki , Hatori Kuniyuki 
Published: October 2019

AbstractThe interplay between intermediate filaments (IFs) and other cytoskeletal components is important for the integrity and motility of cells. The impact of IF assembly on other components and cell morphology is not yet fully understood. Therefore, we examined the effects of combined desmin and actin assembly on cytoskeletal network arrangement in artificial cell‐sized droplets. Fluorescently labeled desmin, with or without actin, was enclosed in droplets prepared with 1,2‐dioleoyl‐sn‐glycero‐3‐phosphoethanolamine (DOPE) using the water‐in‐oil method. Protein networks were observed using fluorescence microscopy in the presence of 150 mM KCl, 20 mM imidazole–HCl (pH 7.4), 2 mM MgCl2, and 1 mM adenosine 5'‐triphosphate for both desmin and actin assembly. As desmin alone can assemble into filaments within seconds, desmin networks mainly localizing at the inner margins of the droplets were observed within 10 min after assembly initiation. Subsequently, deformations of droplets appeared. Furthermore, a portion of droplets formed desmin‐rich protrusions of several micrometers. Notably, actin alone rarely formed protrusions under the same conditions. When 1,2‐dioleoyl‐sn‐glycero‐3‐phosphocholine was used instead of DOPE, protrusions became less frequent. The combination of desmin and actin increased the number of deformed droplets in which the proteins were considerably colocalized. The assembly process of desmin facilitated colocalization. Atomic force microscopy failed to reveal interactions between the two filament types. These results suggest that the mechanical properties of desmin networks may influence the behavior of actin networks, as well as membrane morphology, possibly reflecting the mechanical function of desmin filaments in muscle cells.
Expression mapping, quantification, and complex formation of GluD1 and GluD2 glutamate receptors in adult mouse brain
Authors: Nakamoto Chihiro , Konno Kohtarou , Miyazaki Taisuke , Nakatsukasa Ena , Natsume Rie , Abe Manabu , Kawamura Meiko , Fukazawa Yugo , Shigemoto Ryuichi , Yamasaki Miwako , Sakimura Kenji , Watanabe Masahiko 
Published: October 2019

AbstractIn the cerebellum, GluD2 is exclusively expressed in Purkinje cells, where it regulates synapse formation and regeneration, synaptic plasticity, and motor learning. Delayed cognitive development in humans with GluD2 gene mutations suggests extracerebellar functions of GluD2. However, extracerebellar expression of GluD2 and its relationship with that of GluD1 are poorly understood. GluD2 mRNA and protein were widely detected, with relatively high levels observed in the olfactory glomerular layer, medial prefrontal cortex, cingulate cortex, retrosplenial granular cortex, olfactory tubercle, subiculum, striatum, lateral septum, anterodorsal thalamic nucleus, and arcuate hypothalamic nucleus. These regions were also enriched for GluD1, and many individual neurons coexpressed the two GluDs. In the retrosplenial granular cortex, GluD1 and GluD2 were selectively expressed at PSD‐95‐expressing glutamatergic synapses, and their coexpression on the same synapses was shown by SDS‐digested freeze‐fracture replica labeling. Biochemically, GluD1 and GluD2 formed coimmunoprecipitable complex formation in HEK293T cells and in the cerebral cortex and hippocampus. We further estimated the relative protein amount by quantitative immunoblotting using GluA2/GluD2 and GluA2/GluD1 chimeric proteins as standards for titration of GluD1 and GluD2 antibodies. Intriguingly, the relative amount of GluD2 was almost comparable to that of GluD1 in the postsynaptic density fraction prepared from the cerebral cortex and hippocampus. In contrast, GluD2 was overwhelmingly predominant in the cerebellum. Thus, we have determined the relative extracerebellar expression of GluD1 and GluD2 at regional, neuronal, and synaptic levels. These data provide a molecular–anatomical basis for possible competitive and cooperative interactions of GluD family members at synapses in various brain regions.
Neuroarchitecture of the central complex of the desert locust: Tangential neurons
Authors: von Hadeln Joss , Hensgen Ronja , Bockhorst Tobias , Rosner Ronny , Heidasch Ronny , Pegel Uta , Quintero Pérez Manuel , Homberg Uwe 
Published: October 2019

AbstractThe central complex (CX) comprises a group of midline neuropils in the insect brain, consisting of the protocerebral bridge (PB), the upper (CBU) and lower division (CBL) of the central body and a pair of globular noduli. It receives prominent input from the visual system and plays a major role in spatial orientation of the animals. Vertical slices and horizontal layers of the CX are formed by columnar, tangential, and pontine neurons. While pontine and columnar neurons have been analyzed in detail, especially in the fruit fly and desert locust, understanding of the organization of tangential cells is still rudimentary. As a basis for future functional studies, we have studied the morphologies of tangential neurons of the CX of the desert locust Schistocerca gregaria. Intracellular dye injections revealed 43 different types of tangential neuron, 8 of the PB, 5 of the CBL, 24 of the CBU, 2 of the noduli, and 4 innervating multiple substructures. Cell bodies of these neurons were located in 11 different clusters in the cell body rind. Judging from the presence of fine versus beaded terminals, the vast majority of these neurons provide input into the CX, especially from the lateral complex (LX), the superior protocerebrum, the posterior slope, and other surrounding brain areas, but not directly from the mushroom bodies. Connections are largely subunit‐ and partly layer‐specific. No direct connections were found between the CBU and the CBL. Instead, both subdivisions are connected in parallel with the PB and distinct layers of the noduli.
Static code transformations for thread‐dense memory accesses in GPU computing
Authors: Kim Hyunjun , Hong Sungin , Park Jeonghwan , Han Hwansoo 
Published: October 2019

SummaryDue to the GPU's complex memory system and massive thread‐level parallelism, application programmers often have difficulty optimizing GPU programs. An essential approach to memory optimization is to utilize low‐latency on‐chip memory to avoid high latency of off‐chip memory accesses. Shared memory is an on‐chip memory, which is explicitly managed by programmers. Shared memory has a read/write latency similar to that of the L1 cache, but poor data management can degrade performance. In this paper, we present a static code transformation that preloads dataset in GPU's shared memory. Our static analysis primarily targets global memory requests with high thread‐density for preloading in shared memory. The thread‐dense memory access pattern is a pattern in which many threads efficiently manage the address space of shared memory, as well as reuse the same data in a thread block. We limit the usage of shared memory so that thread‐level parallelism remains at the same level when selecting datasets for preloading. Finally, our source‐to‐source compiler allows to preload selected datasets in shared memory by transforming non‐optimized GPU kernel code. Our methods achieve 1.26× and 1.62× speedups on average (geometric mean), respectively with GTX980 and P100 GPUs.
The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development
Authors: Yu H‐M Ivy , Hsu Trunee , Maruyama Eri O , Paschen Wulf , Yang Wei , Hsu Wei 
Published: October 2019

AbstractSmall ubiquitin‐related modifier (SUMO)‐specific protease 2 (SENP2) is essential for the development of healthy placenta. The loss of SENP2 causes severe placental deficiencies and leads to embryonic death that is associated with heart and brain deformities. However, tissue‐specific disruption of SENP2 demonstrates its dispensable role in embryogenesis and the embryonic defects are secondary to placental insufficiency. SENP2 regulates SUMO1 modification of Mdm2, which controls p53 activities critical for trophoblast cell proliferation and differentiation. Here we use genetic analyses to examine the involvement of SUMO2 and SUMO3 for SENP2‐mediated placentation. The results indicate that hyper‐SUMOylation caused by SENP2 deficiency can be compensated by reducing the level of SUMO modifiers. The placental deficiencies caused by the loss of SENP2 can be alleviated by the inactivation of gene encoding SUMO2 or SUMO3. Our findings demonstrate that SENP2 genetically interacts with SUMO2 and SUMO3 pivotal for the development of three major trophoblast layers. The alleviation of placental defects in the SENP2 knockouts further leads to the proper formation of the heart structures, including atrioventricular cushion and myocardium. SUMO2 and SUMO3 modifications regulate placentation and organogenesis mediated by SENP2.
Effect of coal blending on ash fusion behavior for blast furnace injection of high calcium bituminous coal
Authors: Li Yanjiang , Zhang Jianliang , Wang Guangwei , Qiao Junqiang , Wang Peng , Liang Wang 
Published: October 2019

AbstractIn order to expand the range of bituminous coal injected into blast furnace, the ash melting behavior and regulation mechanism of bituminous with high calcium and low ash fusion temperature (AFT) were investigated by coal blending. And the mineral transformation behavior in the blended ashes was investigated by X‐ray powder diffractometry with normalized reference intensity ratio software and FactSage software. The experimental results manifest that the softening temperature (ST) of coal D is 8°C lower than that of the hot blast temperature. By adequately mixing coal B and coal D, it is easy to meet the requirements of pulverized coal injection. And coal D has become a standard bituminous for blast furnace injection. However, the high content of CaO in the coal S ash makes the AFT much lower than the hot blast temperature, which leads to the reluctance of the steel industry to inject coal S. With the increase of coal B mass ratio, the content of high‐melting eutectic matters (3Al2O3·2SiO2 and tridymite) increases at high temperature, while the content of low‐melting anorthite, andradite, gehlenite, and grossularite decreases, which leads to the increase of AFTs. The variation in the liquid phase under certain conditions reflects the change in AFT. In summary, by blending with coal B, the ST of blended coals S/B is higher than the hot blast temperature (1250°C), so that coal S can be applied to blast furnace injection. And the injection ratio of coal S in blended coals can reach about 50%.
Bioconcentration, Metabolism, and Spatial Distribution of 14C-Labeled Laurate in the Freshwater Amphipod Hyalella azteca
Authors: Raths Johannes , Kuehr Sebastian , Schlechtriem Christian 
Published: October 2019

Abstract
Regulatory assessment of the bioaccumulation from water is commonly based on bioconcentration factors (BCFs) derived from fish flow-through tests. Such experiments require many laboratory animals and are time-consuming and costly. An alternative test setup for organic, neutral compounds using the amphipod Hyalella azteca was recently suggested, resulting in BCF values which show a strong correlation with fish BCF data. In the present study, the bioconcentration potential of the ionic compound laurate was elucidated in H. azteca. The sodium salt of 1-14C laurate was applied to H. azteca in a flow-through and a semistatic approach. Because of rapid biodegradation, a semistatic approach with frequent medium replacements was required to ensure a stable medium concentration. Laurate was also rapidly metabolized by H. azteca. A large proportion of the total radioactivity measured in the amphipod tissue was not extractable, suggesting that mineralized laurate was accumulated in the calcified exoskeleton of H. azteca. This was confirmed in a further study using carbonate [14C]. A lipid-normalized (5.0%) Hyalella BCF of 8.9 was calculated for laurate, measured as free fatty acids. The results of the bioconcentration studies with H. azteca confirm the low bioaccumulation potential of the test item previously observed in fish. However, more organic ionic compounds with various properties need to be tested to assess whether a general correlation between fish and Hyalella BCF data exists. Environ Toxicol Chem 2020;39:310–322. © 2019 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC.
The hepatoprotective activities of Kalimeris indica ethanol extract against liver injury in vivo
Authors: Wang Guo‐Kai , Zhang Nan , Wang Yi , Liu Jin‐Song , Wang Gang , Zhou Zhong‐Yu , Lu Chi‐Cheng , Yang Jai‑Sing 
Published: October 2019

AbstractKalimeris indica (L.) Sch. Bip. is a traditional Chinese medicine (TCM) and a portion of food used for cooking in China. It has been demonstrated that an ethanol extract of K. indica has an anti‐inflammatory effect by inhibition of nitric oxide (NO) production on murine macrophage RAW264.7 cells after lipopolysaccharide (LPS) induction. In this study, the hepatoprotective effects of the total phenolics of K. indica (TPK), the total triterpenes of K. indica (TTK), and the total flavones of K. indica (TFK) from ethanol extracts of K. indica were evaluated in Bacille Calmette–Guerin (BCG)/LPS‐induced liver injury in vivo. The treatments of TPK, TTK, and TFK improved liver injury in mice. Additionally, all treatments significantly not only reduced the hepatic malondialdehyde (MDA) content and hepatic total nitric oxide synthase (tNOS) but also induced the hepatic superoxide dismutase (SOD) and glutathione peroxidase (GSH‐Px) activity. The treatments of TPK and TTK significantly reduced the hepatic inducible nitric oxide synthase (iNOS). The treatments of TPK, TTK, and TFK reduced the serum total bilirubin (T‐Bil), and only TFK treatment reduced the serum alanine aminotransferase (ALT). Our results suggest that TPK, TTK, and TFK from ethanol extracts of K. indica might play an essential protective role against BCG/LPS‐induced liver injury in vivo.
Linear and nonlinear interrelations show fundamentally distinct network structure in preictal intracranial EEG of epilepsy patients
Authors: Müller Michael , Caporro Matteo , Gast Heidemarie , Pollo Claudio , Wiest Roland , Schindler Kaspar , Rummel Christian 
Published: October 2019

AbstractResection of the seizure generating tissue can be highly beneficial in patients with drug‐resistant epilepsy. However, only about half of all patients undergoing surgery get permanently and completely seizure free. Investigating the dependences between intracranial EEG signals adds a multivariate perspective largely unavailable to visual EEG analysis, which is the current clinical practice. We examined linear and nonlinear interrelations between intracranial EEG signals regarding their spatial distribution and network characteristics. The analyzed signals were recorded immediately before clinical seizure onset in epilepsy patients who received a standardized electrode implantation targeting the mesiotemporal structures. The linear interrelation networks were predominantly locally connected and highly reproducible between patients. In contrast, the nonlinear networks had a clearly centralized structure, which was specific for the individual pathology. The nonlinear interrelations were overrepresented in the focal hemisphere and in patients with no or only rare seizures after surgery specifically in the resected tissue. Connections to the outside were predominantly nonlinear. In all patients without worthwhile improvement after resective treatment, tissue producing strong nonlinear interrelations was left untouched by surgery. Our findings indicate that linear and nonlinear interrelations play fundamentally different roles in preictal intracranial EEG. Moreover, they suggest nonlinear signal interrelations to be a marker of epileptogenic tissue and not a characteristic of the mesiotemporal structures. Our results corroborate the network‐based nature of epilepsy and suggest the application of network analysis to support the planning of resective epilepsy surgery.
Hippocampal gamma rhythms during Y‐maze navigation in the juvenile rat
Authors: McHail Daniel G. , Dumas Theodore C. 
Published: October 2019

AbstractThe neurobiology of postnatal hippocampal development in rodents is receiving increased attention as a means to address neurodevelopmental questions and to better understand the neural code(s) for spatial navigation in adulthood. We previously showed that spontaneous alternation (SA) in a Y‐maze, which emerges at the end of the third postnatal week, was related to changes in fast glutamatergic synaptic transmission. In adults, oscillations in the hippocampal local field potential (LFP) (i.e., theta, 4–12 Hz; slow gamma, 25–55 Hz; and fast gamma, 65–100 Hz) have been shown to coordinate the activity of spatially tuned cell types in the hippocampus during route planning and execution. Other investigators have shown that theta activity matures during the first month of life. However, relationships between developmental alterations in gamma oscillations and cognitive function have not been investigated in juveniles, and the impact of developmental changes in excitatory synaptic transmission on network activity remains unclear. We implanted rats at postnatal day 14 to record LFPs from the synaptic layer of area CA1 during Y‐maze exploration at postnatal Days 18, 19, 23, and 24. The positive allosteric modulator of AMPA receptors, CX614, or vehicle was administered prior to each test. We found that slow gamma peak frequency, but not peak power, remained constant across this age range. Fast gamma event rate increased with increasing age, while peak frequency decreased. AMPA receptor modulation impacted slow and fast gamma differently at different ages. Furthermore, gamma events showed relationships with novelty and movement speed that differed based on gamma sub‐band (slow vs. fast). These results support the presence of environmentally‐driven gamma oscillations in hippocampal network activity prior to the end of the third postnatal week of development. Differential refinement of slow and fast gamma occurring across the subsequent week supports involvement in the emergence of spatial navigation ability.