bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cortical Tonotopic Map Changes in Humans Are Larger in Hearing Loss Than in Additional Tinnitus
Authors: Koops Elouise A. , Renken Remco J. , Lanting Cris P. , van Dijk Pim 
Published: March 2020

Neural plasticity due to hearing loss results in tonotopic map changes. Several studies have suggested a relation between hearing loss-induced tonotopic reorganization and tinnitus. This large fMRI study on humans was intended to clarify the relations between hearing loss, tinnitus, and tonotopic reorganization. To determine the differential effect of hearing loss and tinnitus, both male and female participants with bilateral high-frequency hearing loss, with and without tinnitus, and a control group were included. In a total of 90 participants, bilateral cortical responses to sound stimulation were measured with loudness-matched pure-tone stimuli (0.25-8 kHz). In the bilateral auditory cortices, the high-frequency sound-evoked activation level was higher in both hearing-impaired participant groups, compared with the control group. This was most prominent in the hearing loss group without tinnitus. Similarly, the tonotopic maps for the hearing loss without tinnitus group were significantly different from the controls, whereas the maps of those with tinnitus were not. These results show that higher response amplitudes and map reorganization are a characteristic of hearing loss, not of tinnitus. Both tonotopic maps and response amplitudes of tinnitus participants appear intermediate to the controls and hearing loss without tinnitus group. This observation suggests a connection between tinnitus and an incomplete form of central compensation to hearing loss, rather than excessive adaptation. One implication of this may be that treatments for tinnitus shift their focus toward enhancing the cortical plasticity, instead of reversing it.SIGNIFICANCE STATEMENTTinnitus, a common and potentially devastating condition, is the presence of a “phantom” sound that often accompanies hearing loss. Hearing loss is known to induce plastic changes in cortical and subcortical areas. Although plasticity is a valuable trait that allows the human brain to rewire and recover from injury and sensory deprivation, it can lead to tinnitus as an unwanted side effect. In this large fMRI study, we provide evidence that tinnitus is related to a more conservative form of reorganization than in hearing loss without tinnitus. This result contrasts with the previous notion that tinnitus is related to excessive reorganization. As a consequence, treatments for tinnitus may need to enhance the cortical plasticity, rather than reverse it.
Prognostic Value of Germline DNA Repair Gene Mutations in De Novo Metastatic and Castration-Sensitive Prostate Cancer
Authors: Wei Yu , Wu Junlong , Gu Weijie , Wang Jun , Lin Guowen , Qin Xiaojian , Dai Bo , Gan Hualei , Ye Dingwei , Zhu Yao 
Published: March 2020

Abstract

Background
Germline DNA damage repair gene mutations (gDDRm) have been found in approximately 12% of patients with metastatic prostate cancer (mPCa). Previous studies of the clinical impact of gDDRm have mainly been in the setting of metastatic castration-resistant prostate cancer (mCRPC). This study aimed to determine the prognostic value of gDDRm in de novo metastatic and castration-sensitive prostate cancer (mCSPC).

Materials and Methods
We retrospectively collected the records of 139 consecutive men with de novo mCSPC who initially received systemic therapies following guidelines. This included 128 patients who underwent genetic testing at our center and 11 patients referred to our center after being identified as gDDRm carriers. Time to mCRPC was collected. Kaplan-Meier and log-rank analysis were used to analyze the association between gDDRm and clinical outcomes. Survival outcomes were adjusted using multivariable Cox regression models.

Results
Of the 139 patients with de novo mCSPC, 28 gDDRm carriers were identified. Median time progressing to mCRPC was significantly shorter in patients carrying gDDRm than in those without mutations (8.3 vs 13.2 months; hazard ratio [HR], 2.37; p &lt; .001). Moreover, median progression time was almost halved in BRCA2 carriers (6.3 vs. 13.2 months; HR, 3.73; p &lt; .001). Subgroup analysis revealed that the presence of gDDRm indicated poor therapy response regardless of disease volume and prostate-specific antigen nadir within the first 7 months. Presence of gDDRm remained independently associated with increased risk of progression to mCRPC in multivariate analysis (adjusted HR, 1.98; p = .006).

Conclusion
Our study suggested that positive gDDRm status predicted rapid progression to castration resistance in patients with de novo mCSPC. We propose identifying gDDRm status at the time of diagnosis for mCSPC patients, considering it is the first step of tailoring individualized treatment. In addition, DNA repair genes were a good therapeutic target for poly (ADP-ribose) polymerase inhibitors, and our results call for more frontline targeted therapy trials in gDDRm carriers to prolong the progression time.

Implications for Practice
Results of this study suggested that positive germline DNA damage repair gene mutation (gDDRm) status predicted earlier progression to castration resistance in patients with de novo metastatic and castration-sensitive prostate cancer (mCSPC). These findings indicated the importance of intense therapy for some subgroups of mCSPC, especially for mCSPC harboring gDDRm with low-volume disease. Moreover, gDDRm was a good therapeutic target for poly (ADP-ribose) polymerase inhibitors, and these findings call for more molecular marker driven trials moving to the mTNPC setting.
Lomber Disk Hernili Hastalarda İntradiskal Ozon Enjeksiyon Tedavisinin Retrospektif Olarak İncelenmesi
Authors: ÖZTÜRK Ömür , BİLGE Ali , ERBAŞ Mesut 
Published: March 2020

Amaç: Lomber disk hernisi (LDH) toplumda giderek artan bir hastalık olarak karşımıza çıkmaktadır. Günümüzde minimal invaziv tedaviler hem maliyet hem de zaman açısından önemini artırmıştır. Bizde çalışmamızda LDH olan hastalarda minimal invaziv tedavilerden biri olan intradiskal ozon enjeksiyon tedavisinin retrospektif olarak radiküler ağrıda kısa ve uzun dönemde etkilerini incelendik.Gereç ve Yöntemler: Kafkas Üniversitesinde Ağustos 2015-Kasım 2016 tarihleri arasında, LDH sebebiyle ağrı polikliniğimize başvuran ve ameliyathanede C kollu floroskopi eşliğinde intradiskal ozon uygulanan 40 hastanın (13 erkek, 27 kadın) dosyaları geriye dönük olarak incelendi. Bulgular:İşlem öncesi vizuel analog skala (VAS), direk bacak kaldırma testi (DBKT) ve el parmak zemin mesafesi (EPZM) değerleri ile 1. ay ve 6. ay VAS, DBKT VE EPZM değerleri karşılaştırıldığında istatistiksel olarak anlamlı fark saptandı. Sonuç: Günümüzde disk hernilerinde cerrahi tedavi en son alternatif olarak düşünülmekte olup minimal invaziv yöntemler ön plana çıkmıştır. İntradiskal medikal ozon enjeksiyon tedavisinin kısa ve uzun dönemde etkin olduğu ve bu nedenle LDH olan hastalarda tercih edilebilecek bir tedavi yöntemi olduğunu düşünmekteyiz.﻿
UNRAVELING PARENTS' PERCEPTIONS OF ENGLISH LANGUAGE LEARNING
Authors: Diaz Claudio , Acuña Nicolas , Ravanal Barbara , Riffo Ignacio 
Published: March 2020

Purpose of the study: This research aims to analyze parents’ perceptions towards the learning of English and the ways they help their children deal with English and language assessment.
Methodology: This qualitative study addresses 74 Chilean parents’ perceptions of English teaching and learning. A semi-structured interview was conducted to capture the participants’ perceptions. The data were categorized using content and frequency analysis and the principles of metaphoric analysis.
Main findings: The findings suggest that parents hold a positive perception of the English language and believe it is useful for their children’s lives even though they might find the learning of the language difficult.
Social implications/Originality: Participants can produce metaphors that regard English as an ability and metaphors that focus on the process of learning the language. The findings of this research are useful for university stakeholders, teachers, preservice teachers, and students.
Novelty/Originality of this study: In this study parents, stakeholders who have usually left aside from the language teaching and learning process, are interviewed to unfold their perceptions of what they see and believe when their children learn English.
The effectiveness of resource-saving techniques for the cultivation of onions during irrigation in the conditions of the Lower Volga
Authors: Kalmykova E. V. , Novikov A. A. , Petrov N. Yu. , Kalmykova O. V. 
Published: March 2020

Relevance. The main areas under vegetables, including onions, are located in the south of Russia. Inclusion of vegetables in the list of food safety products with a threshold value of 90% will significantly increase the responsibility of agricultural workers at all levels for the production and sale of vegetable products. The purpose of the research is to justify the feasibility and effectiveness of cultivating promising varieties and hybrids of onions during irrigation in the Lower Volga region to obtain yields of 150 or more t/ha of high-quality products.Methods. For the first time in the area of chestnut soils, comprehensive scientific research was conducted on resource-saving techniques to increase the productivity of a vegetable crop in an extremely arid climate by regulating the physiological and biological processes during drip irrigation, and a system was developed for applying these techniques. Research in the experiment was carried out according to generally accepted methods.Results. The most significant increase in the onion crop was obtained on the variants of the complex application of the studied agricultural methods and amounted, on average, for 2011...2016 with an irrigation regime of 75...75...75% of HB on the standard variety Volgodonets – 159%, relative to the control, on a promising hybrid Octant F1 – 118%, on the hybrid – 125%. With the regime of 70...80...75% of HB on the Volgodonets standard grade – 155%, relative to control, on the promising Oktant F1 hybrid 113%, on the Valero F1 hybrid – 115%. When calculating the cultivation efficiency of this crop, economic data were obtained, the value of which allows us to conclude that when planning the growth of onion production efficiency, agricultural producers are recommended to introduce agricultural technology with a profitability of 253.63%: promising hybrid Octant F1, irrigation mode – differentiated, background N450P180K135+Mortar+Energy-M. Against this background, in the context of research on the variety and hybrids, the maximum return on production costs is 3.2 rubles. An analysis of data on a combination of crop-forming factors showed that for onions when cultivating promising hybrids Octant F1 and Valero F1, when planning yields of 130 and 150 t/ha, it is necessary to maintain a moisture level of 70...80...75% HB, and when grown without fertilizers and when planning 110 t/ha it is enough to create a permanent irrigation regime.
Rooting stimulation of “Victoria” and “Korinka russkaya” grape hardwood cuttings as influenced by potassium salt of Indolyl-3-Acetic Acid (KIAA)
Authors: Shaimaa I. H. , Shalamova A. A. , Abramov A. G. 
Published: March 2020

Relevance. Applying exogenous auxins to the cuttings of grapevines is a common practice in viticulture to improve the rooting process. The potassium salt formulations of auxins have been documented to be more, less, or equally efficient as acid formulations in rooting stimulation of cuttings depending on the genetic features of the plant, type and concentration of auxin, type of cuttings, and many other factors.Methods. The present study aimed at evaluating the effect of potassium salt of indolyl-3-acetic acid (KIAA) on rooting of the hardwood cuttings of two grape cultivars namely, Korinka russkaya and Victoria, which are commonly planted by grape growers of the Tatarstan Republic. The study was conducted in 2018 and 2019 under hydroponic conditions in a controlled-environment growth chamber in Kazan State Agrarian University. The cuttings were treated with 1) KIAA at two concentrations (5,000 and 10,000) ppm; 2) β-indolyl-butyric acid (IBA) 3,000 ppm (as a check treatment) and 3) distilled water as a control.Results. Based upon the overall results, KIAA significantly improved the rooting process of both investigated cultivars. Rooting percentage, average number of roots on cuttings as well as the quality of the root system was enhanced with increasing auxin concentration up to 10,000 ppm. IBA also improved the rooting quality parameters over the controls. The two grape cultivars differed significantly in their rooting capacity: cuttings of Korinka russkaya in both years had greater values of all the studied parameters compared with those of Victoria cultivar except for the callusing percentage, which was higher in Victoria.
Nutritional value of salad Crimean onion
Authors: Golubkina N. A. , Nemtinov V. I. , Kostanchuk Yu. N. , Caruso G. , Agafonov A. F. , Mastyaev I. S. , Nadezhkin S. M. 
Published: March 2020

Relevance.Allium cepaL. is considered to be one of the most important agricultural crops in most countries of the world. High nutritional value is especially pronounced in salad onion which vegetation needs high temperature and significant insulation.Material and methods. The first biochemical characteristics are given for 9 Crimean salad onion genotypes and varieties (red onions Festivalny, Yaltinsky plus, Yaltinsky foros, Yaltinsky rybin, Yaltinsky 6А, Yaltinsky 7А, Yaltinsky 8А and yellow cultivars Kendy and Bean promine) with the comparison with the appropriate data for popular Italian sweet onion cultivar Tropea and semi-pungent varieties grown in Moscow region, Italy and Stavropol region (Zolotnichok, Cherny prince).Results. Warm climate is shown to increase the amount of antioxidants, monosaccharides and organic acids in onion bulbs. Compared to the Italian Tropea variety Crimean genotypes were characterized by higher levels of ascorbic acid (12.8±1.4 mg/100 g fresh weight) and organic acids (1.58±0.03 mg malic acid per g of dry weight), relatively similar levels of polyphenols (21.0±2.3 mg-eq Gallic acid per g of dry weight), and quercetine. (3.09±0.42 mg-eq Gallic acid per g of dry weight) and antocyanines (2.78±1.03 mg/g fresh weight). New genotypes Yaltinsky 6A, Yaltinsky 7A, Yaltinsky 8A were shown to accumulate higher levels of antioxidants. A direct correlation between the peel/inner layers ratio of antioxidant activities with the appropriate ratio for polyphenols was demonstrated (r=+0.93). A direct correlation between flavonoids content in peel and inner layers was also revealed (r=+0.83). Polyphenols and flavonoids ratios between peel and inner layers were shown to be higher for the Crimean genotypes compared to semi-pungent Moscow region varieties which indicates the prospects of utilization of the Crimean onion peel in production of functional food products with elevated levels of antioxidants.
Political Communication of Hasan Basri Agus; Dramaturgical Analysis in Jambi Local Government Implementation
Authors: Yahya Ahmad Harun 
Published: March 2020

Hasan Basri Agus was the winner of the Jambi local election in 2010. Start his career from civil servant, and then became head of subdistrict before he was choosen as regent of Sarolangun and the last he was elected as Jambi governor in the period of 2010-2015. In the applied of his government, Hasan Basri Agus applied the principles of political communication as an important way to build interaction relationship with Jambi communities. The research uses a qualitative method by using a constructive paradigm. Based on constructive paradigm, the next approach the researcher use in a dramaturgical analysis. This research sought to give an objective analysis of the political communication of the Jambi Governor in the applied of his government. The result of the research show that Hasan Basri Agus succesfully represented him self as people protector, religious, and charismatic leader.
Generational Professional Career Evolution of Professionals in Computer Science in Costa Rica
Authors: Calderón Marta Eunice , Marín Gabriela , López Gustavo 
Published: March 2020

The career evolution of computing professionals has been studied very little, especially in Latin America. In a previous study (LAWWCC 2016) we reported results of an exploratory study that aimed to characterize the professional development model of people that studied Computer Sciences in Costa Rica. It reflects the roles and the industrial sectors with which they began their professional career and in which they report are currently working. No important gender differences were depicted in it amongst men and women, since they report similar choices regarding their professional evolution. As a result, some valid concerns were raised regarding the question: do these results represent the female (and male) behavior in all professional career stages? In this study, results, obtained from an online survey responded by 611 professionals in Computer Sciences, are now shown by generations. Professionals are grouped in four generational categories: Baby Boomers, Generation X, Young and Mature Millennials. The main finding is that the professional evolution, with respect to the role and sector in which they perform, revels different behaviors for professionals of different generations. It also reflects that male career evolution shows more role and industry changes than that of female professionals.
A SURVEY FOR ZOONOTIC AND OTHER GASTROINTESTINAL PARASITES IN PIG IN BALI PROVINCE, INDONESIA
Authors: Widisuputri Ni Komang Aprilina , Suwanti Lucia Tri , Plumeriastuti Hani 
Published: March 2020

Pigs have potentially to transmit zoonotic gastrointestinal parasite disease both caused by protozoa and worm. The aim of this study was to identify gastrointestinal parasites that were potentially zoonotic in pigs in the province of Bali. A total of 100 fresh feces samples was collected from several pig farms in Bali, from Badung and Tabanan districts, each consisted of 50 samples. Pig feces samples were examined for the presence of eggs worms, cysts and oocysts for protozoa based on the morphology and size. Identification for protozoa and worms used native, sedimentation and sucrose flotation methods. Parameters measured were sex, feed and cage management. The result showed that the characteristic parameters for pigs in both district were generally female. Cage management for raising pigs mostly used group cage. Feed that provided in both district mostly used bran and concentrate. All of 100 pig feces samples that examined positive for parasites. There were 8 types of gastrointestinal parasites that have been identified. Four types of protozoa found were Entamoeba sp. (99%), Balantidium sp. (79%), Eimeria sp. (78%), Blastocystis sp. (69%) and four types of worms were Ascaris sp. (20%), Trichuris sp. (20%), Strongyloides sp. (19%), and Oesophagostomum sp. (8%). All pigs were infected with two or more parasites. The prevalence of parasitic gastrointestinal infections was different for each district, six genera (Entamoeba sp., Balantidium sp., Blastocystis sp., Eimeria sp., Oesophagostomum sp. and Trichuris sp.) were higher found in Tabanan district and the two genera (Ascaris sp. and Strongyloides sp.) were higher in Badung district. Oesophagostomum sp. was only found to infect pigs in Tabanan district. The conclusion is gastrointestinal parasites that found in pigs at Badung and Tabanan district Bali Province mostly have zoonotic potential.
SENSITIVITY OF ERYTHROMYCIN AGAINST CORYNEBACTERIUM DIPHTHERIAE
Authors: Mutahhar Alif , Puspitasari Dwiyanti 
Published: March 2020

Diphtheria is an acute infection disease caused by Corynebacterium diphtheriae. It remains a problem in Indonesia in a recent several years especially in East Java Province, which suffered from an outbreak of diphtheria in 2011. Erythromycin is the second line antibiotics therapy for diphteria if the patient is allergic to penicillin, also serving as a prophylactic and carrier therapy for contact diphtheria. Erythromycin has been used for diphtheria for a very long time, but there is little recent data on its sensitivity against C. diphtheriae. The purpose of this study is to identify whether Erythromycin still has a strong antibacterial activity against Corynebacterium diphtheriae by invitro test. This was a descriptive study which observed the sensitivity pattern of erythromycin against Corynebacterium diphtheriae using the Epsilometer test (etest) as a diffusion technique. Samples used in this study were 30 isolates of toxigenic Corynebacterium diphtheriae strain mitis and gravis at the Center for Health Laboratory (BBLK) Surabaya obtained during 2011 until 2014. We retrieved the data based on gender, age, and districts of patients for each of the samples then analyzed them descriptively. In this study, a sensitivity test of 30 toxigenic Corynebacterium diphtheriae isolates revealed that 27 (90%) were sensitive to Erythromycin (average Minimum Inhibitory Concentration/ MIC) <0.016 μg/mL and all were strain mitis, while 3 (10%) had intermediate sensitivity with MIC 1 μg/mL (all were strain gravis). No resistance result was found from the sensitivity test. According to the result, we conclude that Erythromycin still has a strong antibacterial activity against Corynebacterium diphtheriae.
MCP-1 LEVELS AND ATYPICAL LYMPHOCYTES IN EARLY FEVER OF DENGUE VIRUS INFECTION WITH NON-STRUCTURAL PROTEIN 1 (NS-1) ANTIGEN TEST IN dr DARSONO HOSPITAL, PACITAN
Authors: Agustiningrum Indah , Nugraha Jusak , Kahar Hartono 
Published: March 2020

Dengue infection caused by DENV and transmitted by mosquitoes Aedes aegypti and Aedes albopictus is a major health problem in the world, including Indonesia. Clinical manifestations of dengue infection are very widely, from asymptomatic until dengue shock syndrome (DSS). DENV will attack macrophages and dendritic cells (DC) and replicate them. Monocytes are macrophages in the blood (±10% leukocytes). Macrophages produce cytokines and chemokines such as monocyte chemotactic protein-1 (MCP-1)/CCL2. The monocytes that are infected with DENV will express MCP-1, which will increase the permeability of vascular endothelial cells so that they have a risk of developing DHF/DSS. Macrophages and DC secrete NS1 proteins, which are the co-factors that are needed for viral replication and can be detected in the early phase of fever. The increased MCP-1 levels in dengue infection followed by an increase in the number of atypical lymphocytes indicate the arrival of macrophages and monocytes to the site of inflammation which triggers proliferation rather than lymphocytes. This is an observational analytical study with a cross-sectional design to determine the MCP-1 level in dengue infection patients with 1st until the 4th day of fever and the presence of atypical lymphocytes. Dengue infection was determined by rapid tests NS1 positive or negative and MCP-1 levels were measured using by ELISA sandwich method.MCP-1 level of sixty patients dengue infection NS-1 rapid positive or negative with 2nd until 4rt fever were significantly higher than healthy subjects (420.263±158,496vs29, 475±23.443;p=0.000), but there was no significant difference in subjects with DF, DHF or DSS (436,47±225,59 vs422,77±170,55vs 448,50±117,39; p =0.844). Atypicallymphosite differs significantly in healthy subjects than subjects infected with DENV an average of 2% (p= 0,000). In conclusion, this shows the arrival of macrophages and monocytes to the site of inflammation, which triggers the proliferation of lymphocytes.