bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influenza-associated cardiovascular mortality in older adults in Beijing, China: a population-based time-series study
Authors: Liu Rong , Liu Xiaoshuang , Yang Peng , Du Xin , He Liu , Chen Tiange , Li Xiang , Xie Guotong , Wu Shuangsheng , Su Jianting , Xia Shijun , Jiang Chao , Huffman Mark D. , MacIntyre Chandini Raina , Wei Zaihua , Wang Quanyi , Dong Jianzeng , Anderson Craig 
Published: November 2020

ObjectiveThis study comprehensively estimated the excess cardiovascular disease (CVD) mortality attributable to influenza in an older (age ≥65 years) population.DesignEcological study.SettingAggregated data from administrative systems on CVD mortality, influenza surveillance and meteorological data in Beijing, China.Main outcome measureExcess overall CVD, and separately for ischaemic heart disease (IHD), ischaemic stroke, haemorrhagic stroke mortality attributable to influenza, adjusting for influenza activity, time trend, seasonality and ambient temperature.ResultsCVD (risk ratio (RR) 1.02, 95% CI 1.01, 1.02), IHD (RR 1.01, 95% CI 1.01, 1.02), ischaemic stroke (RR=1.03, 95% CI 1.02, 1.04), but not haemorrhagic stroke (RR=1.00, 95% CI 0.99, 1.01) mortality, were significantly associated with every 10% increase in influenza activity. An increase in circulating A(H1N1)09pdm, A(H3N2) and B type virus were all significantly associated with CVD and ischaemic stroke mortality, but only A(H3N2) and B type virus with IHD mortality. The strongest increase in disease mortality was in the same week as the increase in influenza activity. Annual excess CVD mortality rate attributable to influenza ranged from 54 to 96 per 100 000 population. The 3%–6% CVD mortality attributable to influenza activity was related to an annual excess of 916–1640 CVD deaths in Beijing, China.ConclusionsInfluenza activity has moderate to strong associations with CVD, IHD and ischaemic stroke mortality in older adults in China. Promoting influenza vaccination could have major health benefit in this population.BackgroundInfluenza may trigger serious CVD events. An estimation of excess CVD mortality attributable to influenza has particular relevance in China where vaccination is low and CVD burden is high.MethodsThis study analysed data at the population level (age ≥65 years) using linked aggregated data from administrative systems on CVD mortality, influenza surveillance and meteorological data during 2011 to 2018. Quasi-Poisson regression models were used to estimate the excess overall CVD, and separately for IHD, ischaemic stroke, haemorrhagic stroke mortality attributable to influenza, adjusting for influenza activity, time trend, seasonality and ambient temperature. Analyses were also undertaken for influenza subtypes (A(H1N1)09pdm, A(H3N2) and B viruses), and mortality risk with time lags of 1–5 weeks following influenza activity in the current week.
String fragmentation with a time-dependent tension
Authors: Hunt-Smith Nicholas , Skands Peter 
Published: November 2020

AbstractMotivated by recent theoretical arguments that expanding strings can be regarded as having a temperature that is inversely proportional to the proper time, $$\tau $$
τ
, we investigate the consequences of adding a term $$\propto 1/\tau $$

∝
1
/
τ

to the string tension in the Lund string-hadronization model. The lattice value for the tension, $$\kappa _0 \sim 0.18\,{\mathrm {GeV}}^2\sim 0.9\,{\mathrm {GeV}}/{\mathrm {fm}}$$

κ
0

∼
0.18

GeV

2

∼
0.9

GeV
/
fm

, is then interpreted as the late-time/equilibrium limit. A generic prediction of this type of model is that early string breaks should be associated with higher strangeness (and baryon) fractions and higher fragmentation $$\langle p_\perp \rangle $$

⟨

p
⊥

⟩

values. It should be possible to use archival ee data sets to provide model-independent constraints on this type of scenario, and we propose a few simple key measurements to do so.
2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy: Executive Summary
Authors:   Writing Committee Members, Ommen Steve R. , Mital Seema , Burke Michael A. , Day Sharlene M. , Deswal Anita , Elliott Perry , Evanovich Lauren L. , Hung Judy , Joglar José A. , Kantor Paul , Kimmelstiel Carey , Kittleson Michelle , Link Mark S. , Maron Martin S. , Martinez Matthew W. , Miyake Christina Y. , Schaff Hartzell V. , Semsarian Christopher , Sorajja Paul 
Published: November 2020

Aim
This executive summary of the hypertrophic cardiomyopathy clinical practice guideline provides recommendations and algorithms for clinicians to diagnose and manage hypertrophic cardiomyopathy in adult and pediatric patients as well as supporting documentation to encourage their use.

Methods
A comprehensive literature search was conducted from January 1, 2010, to April 30, 2020, encompassing studies, reviews, and other evidence conducted on human subjects that were published in English from PubMed, EMBASE, the Cochrane Collaboration, Agency for Healthcare Research and Quality reports, and other relevant databases.

Structure
Many recommendations from the earlier hypertrophic cardiomyopathy guidelines have been updated with new evidence or a better understanding of earlier evidence. This summary operationalizes the recommendations from the full guideline and presents a combination of diagnostic work-up, genetic and family screening, risk stratification approaches, lifestyle modifications, surgical and catheter interventions, and medications that constitute components of guideline directed medical therapy. For both guideline-directed medical therapy and other recommended drug treatment regimens, the reader is advised to follow dosing, contraindications and drug-drug interactions based on product insert materials.
Understanding the Scope of the Institutional Transformation within the Microfinance Sector: Evidence from Sidian Bank in Kenya
Authors: Biringanine Alexis Nyamugira 
Published: November 2020

Abstract
This article investigates the impact of the change in the legal status of a microfinance institution on its social and financial performance. It uses a case study with a strong emphasis on both quantitative and qualitative approaches to understand the stakeholders’ perceived value of transformation. The results from the study reveal that transformation significantly improves the profitability and the efficiency of Sidian Bank, and in addition, improves the quality of its portfolio. However, we found that transformation has altered significantly the social objectives of Sidian Bank by decreasing its breadth and depth of social outreach. Insights from the qualitative approach reveal that the average loan size widely used to proxy mission drift is a biased indicator since clients grow over time and always favor bigger loans. The stakeholders’ perceived value of transformation differs in terms of risks, breadth, and financial results.
Conducting Non-COVID-19 Clinical Trials during the Pandemic: Can Today’s Learning Impact Framework Efficiency?
Authors: Lalova Teodora , Negrouk Anastassia , Deleersnijder Angelique , Valcke Peggy , Huys Isabelle 
Published: November 2020

Abstract
The COVID-19 pandemic has severely disrupted non-coronavirus clinical trials. In the case of life-threatening diseases, such as cancer, this is particularly dangerous, as treatment cannot simply be stopped. In the EU, guidelines for the management of ongoing studies were issued; however, national coordination is still lacking. This article aims to raise awareness on the struggle of managing ongoing clinical trials in the EU during the pandemic. The goals are to bring attention, from a legal and regulatory point of view to the difficulties faced by those involved in clinical research, and to critically position the current hurdles against the backdrop of the existing legal and ethical framework. We investigated the EU guidance and the national approaches of all EU/EEA Member States, and critically discussed selected issues. We argue that the crisis may be an opportunity to foresee meaningful changes in the EU clinical trials framework post-COVID-19.
Populist Mediation of the Pandemic
Authors: Marker Silas 
Published: November 2020

Abstract
The potential impact of right-wing populist media on society is a matter of growing importance. This paper examines the discourse of the three Danish right-wing populist media Den Korte Avis, NewsSpeek and 24Nyt during the corona crisis in 2020. Using the post-structuralist theoretical framework and discursive approach to populism of Ernesto Laclau, it finds that despite some differences, all three of them articulate Muslim immigrants as a particular problem demanding particular attention in the corona crisis; they accuse the so-called mainstream media of lying or keeping secrets about the crisis, thereby positioning themselves as mediums of the truth; and they accuse the international institutions of lying and utilizing the corona crisis for their own globalist aims.
Biopolitical Populism in Poland: The Case of PiS
Authors: Yatsyk Alexandra 
Published: November 2020

Abstract
This paper examines the discourse of PiS party in Poland as a form of biopolitical populism. I view this phenomenon as a specific style of political discourse rather than an ideology, that, first, focuses on bodily issues, including family and gender policy, sexual behavior, etc., second—it is inherently performative and as such it appeals to emotions, and, third—it directly communicates with “people” while circumventing the existing institutional framework of the state. Based on the cases of PiS rhetoric on the Smolensk catastrophe, and its narratives on gender and anti-LGBTQ issues, I demonstrate how the latter could be used for political othering and for subverting the core democratic principles. My data includes publications in Polish media and on social platforms (Twitter and Facebook), mostly before and after elections to European and national parliaments in May and October 2019, as well as during the presidential election in spring 2020.
Expansion of chronic lesions is linked to disease progression in relapsing–remitting multiple sclerosis patients
Authors: Klistorner Samuel , Barnett Michael H , Yiannikas Con , Barton Joshua , Parratt John , You Yuyi , Graham Stuart L , Klistorner Alexander 
Published: November 2020

Background: Slow-burning inflammation is putatively associated with lesion expansion and leads to progressive loss of axons and disability worsening. Objective: To investigate the incidence and extent of chronic white matter lesion expansion in relapsing–remitting multiple sclerosis (RRMS) patients and to evaluate its relationship with biomarkers of disease progression. Methods: Pre- and post-gadolinium T1, fluid-attenuated inversion recovery (FLAIR) and diffusion tensor images were acquired from 33 patients. Lesional activity were analysed between baseline and 48 months using custom-designed software. Results: A total of 569 lesions were identified as chronic at baseline, of which 261 were expanding, 236 were stable and 72 were shrinking. In addition, 139 new lesions (both confluent and free-standing) were observed. Chronic lesion expansion was associated with patient’s age and accounted for the bulk (67.3%) of total brain lesion volume increase, while only 32.7% was attributable to new lesion formation. Change in chronic lesion volume correlated with the rate of brain atrophy ( r = −0.57, p = 0.001), change of Expanded Disability Status Scale (EDSS; r = 0.38, p = 0.03) and an increase of isotropic diffusivity inside the lesions ( r = 0.75, p < 0.001). Conclusion: Expansion of chronic lesions in RRMS patients is the primary determinant of increased T2 total lesion load. It significantly contributes to disease progression and partially driving axonal loss inside the lesions and brain damage outside of lesional tissue.
Disparities of perceived wellness by smoking and professional status among young individuals in Brasov, Brasov County, Romania
Authors: Fan Hao , Gao Xiang , Wang Haiping , Idomir Mihaela , Rogozea Liliana , Cazan Ana-Maria , Bidulescu Aurelian , Badea Mihaela 
Published: November 2020

Objective: We aimed to evaluate the association of risk factors such as smoking and professional status (students vs employed) as determinants of disparities in perceived wellness among Romanian individuals. Methods: We conducted a cross-sectional study in which 145 participants were enrolled from December 2017 to February 2018, in Brasov, Brasov County, Transylvania, Romania. We used a simplified Perceived Wellness Survey model to measure the holistic individual perceived wellness status by professional and smoking status. Basic descriptive and multivariate analyses of variance were used to assess and contrast participants’ characteristics and wellness score distributions. A factor analysis was used to estimate Kaiser–Meyer–Olkin values and calculate standardized Cronbach’s coefficients. Results: The average age of our participants was 27.7 years. Compared with students, more employed participants tended to smoke electronic cigarettes ( p < 0.0001). The association between professional status and perceived wellness was non-significant. Employed participants were nevertheless more likely to regard themselves as more proactive in dealing with emotional ( p < 0.0001), environmental ( p = 0.0042), and spiritual issues ( p = 0.0039). Perceived physical wellness was statistically different by smoking status ( p < 0.0001). Conclusion: Among our study participants, there is an association between smoking and perceived wellness. For emotional, environmental, and spiritual domains, employed participants are more likely to regard themselves as more confident. Our study demonstrates the direct application of the Perceived Wellness Survey model in predicting the disparities of perceived wellness among young individuals. It allows health agencies to target disparity interventions among populations with high risk of low perceived wellness.
Retinal Detachment and Laser Retinopexy Rates During the COVID-19 Pandemic
Authors: Janetos Timothy M. , Hall Andrew N. , Gill Manjot K. 
Published: November 2020

Purpose: At the start of March 2020, the COVID-19 pandemic placed an unprecedented burden on the healthcare system. Throughout much of the United States, shelter-in-place orders were imposed to reduce transmission. A consequence of this crisis, risk mitigation orders, and patient fear of exposure may have led to underutilization of emergency services. We aimed to quantify 2 emergent interventions in ophthalmology, specifically acute laser retinopexy procedures and retinal detachment repair, to determine whether these procedures decreased during the start of the pandemic. Methods: All retinal detachment surgeries and laser retinopexy procedures were identified using Current Procedural Terminology codes. Rate data during the study period (March 1 through May 31, 2020) was compared to historical data from the year prior (March 2019 through May 2019; epoch 1) as well as the immediate 3 months prior to the study period (December 2019 through February 2020; epoch 2). Results: Combined procedures fell by 38.5% ( P = .01) and 36.0% ( P = .02) when compared to epoch 1 and epoch 2, respectively. The rate of laser retinopexy procedures fell by 45.5% ( P = .02) and 33.0% ( P = .14) when compared to epoch 1 and epoch 2, respectively. The rate of retinal detachment repair fell by 29.4% ( P = .24) and 38.0% ( P = .07) when compared to epoch 1 and epoch 2, respectively. Conclusions: Procedures fell during the study period, suggesting underutilization of emergent ophthalmology care. It is necessary for ophthalmologists to emphasize the need to seek care for concerning symptoms.
Epigenetics and pulmonary diseases in the horizon of precision medicine: a review
Authors: Benincasa Giuditta , DeMeo Dawn L. , Glass Kimberly , Silverman Edwin K. , Napoli Claudio 
Published: November 2020

Epigenetic mechanisms represent potential molecular routes which could bridge the gap between genetic background and environmental risk factors contributing to the pathogenesis of pulmonary diseases. In patients with COPD, asthma and pulmonary arterial hypertension (PAH), there is emerging evidence of aberrant epigenetic marks, mainly including DNA methylation and histone modifications which directly mediate reversible modifications to the DNA without affecting the genomic sequence. Post-translational events and microRNAs can be also regulated epigenetically and potentially participate in disease pathogenesis. Thus, novel pathogenic mechanisms and putative biomarkers may be detectable in peripheral blood, sputum, nasal and buccal swabs or lung tissue. Besides, DNA methylation plays an important role during the early phases of fetal development and may be impacted by environmental exposures, ultimately influencing an individual's susceptibility to COPD, asthma and PAH later in life. With the advances in omics platforms and the application of computational biology tools, modelling the epigenetic variability in a network framework, rather than as single molecular defects, provides insights into the possible molecular pathways underlying the pathogenesis of COPD, asthma and PAH. Epigenetic modifications may have clinical applications as noninvasive biomarkers of pulmonary diseases. Moreover, combining molecular assays with network analysis of epigenomic data may aid in clarifying the multistage transition from a “pre-disease” to “disease” state, with the goal of improving primary prevention of lung diseases and its subsequent clinical management.We describe epigenetic mechanisms known to be associated with pulmonary diseases and discuss how network analysis could improve our understanding of lung diseases.
Amalgam restoration or just a deposit? A riveting incidental finding- a case report
Authors: Sharma Anka , Kasat Vikrant O. , Parate Amit R. , Upmanyu Anirudh , Pagare Jaishri S. 
Published: November 2020

AbstractBackgroundParafunctional oral habits are known to cause deleterious effects on maxillofacial structures. One such effect is traumatic injuries secondary to chewing inanimate objects like pencils. Following trauma, the lead of the pencil has been reported to embed in the soft tissue of the oral cavity, appearing as a grayish pigmentation (graphite tattoo). However, such pigmentation has never been reported in the hard tissue (teeth).Case presentationWe hereby report an interesting, first of its kind case in a four-year-old female child. She had been misdiagnosed and referred for the management of a carious tooth; which was, in reality, an exogenous deposit.ConclusionsThe authors highlight the impact of comprehensive history taking on arriving at the diagnosis. Counselling of the child and the parents goes a long way in flouting such deleterious habits.
Mix-design and Properties of Mortars from Alkali-activated Fly Ashes Containing High Amounts of Unburned Carbon Matter
Authors: Manzi Stefania , Saccani Andrea , Baldazzi Luca , Lancellotti Isabella 
Published: November 2020

AbstractAlkali-activated materials are a promising type of binder candidate as a substitute to Portland cement. Fly ashes can be used as binder precursors giving higher environmental benefits. In the present research, fly ashes (Type F) containing different amounts of unburned carbonaceous matter have been used to formulate mortars. Serious problems concerning the workability in the fresh state have been found when high carbon content are reached. An attempt to avoid the preliminary treatments used to eliminate the unburned matter is carried out by exploiting different mix-design receipts obtained by changing the water/binder ratio, the ratio of the alkaline activators and using different types of superplasticizer additives. Data so far collected underline that a high amount of unburned carbonaceous matter can not only compromise the mechanical properties of the materials, but also the rheological ones and underline the necessity to develop ad hoc additives for this type of binders.
Sufentanil sublingual tablet system versus oral oxycodone for management of postoperative pain in enhanced recovery after surgery pathway for total knee arthroplasty: a randomized controlled study
Authors: Noel Emmanuel , Miglionico Luca , Leclercq Mickael , Jennart Harold , Fils Jean-François , Van Rompaey Nicolas 
Published: November 2020

Abstract
Purpose
Effectiveness of sufentanil sublingual tablet system (SSTS) compared to oral oxycodone in the management of postoperative pain after total knee arthroplasty (TKA) within an enhanced recovery after surgery (ERAS) protocol.

Methods
This pragmatic, parallel, open label, randomized controlled, trial enrolled 72 adult patients scheduled for TKA under spinal anesthesia following ERAS pathway. In addition to multimodal analgesia, patients received SSTS 15 mcg (SSTS group) or oral oxycodone extended release 10 mg twice daily and oral oxycodone immediate-release 5 mg up to four times daily on demand (Oxy group) to control pain during 48 h postoperatively. The primary endpoint was pain measured using a numeric rating scale at 24 h postoperatively. Time to first mobilization, side effects and patient satisfaction were also recorded.

Results
Median pain score at 24 h at rest was 3 [2–4] for Oxy group vs 2 [1.75–3] for SSTS group (p = 0.272) whereas median pain score on movement was 4 [3–6] vs 3 [2–5] respectively (p = 0.059). No difference in time to first mobilization was found between the two groups. The method of pain control was judged good/excellent for 83.9% of patients in the SSTS group compared with 52.9% in the Oxy group (p = 0.007). The incidence of nausea was 33% in SSTS group and 9% in Oxy group (p = 0.181).

Conclusions
In complement to ERAS multimodal analgesia, sublingual sufentanil 15 mcg tablet system did not show clinically significant pain improvement compared to oral oxycodone after total knee arthroplasty.

Trial registration
Clinical Trials: NCT04448457; retrospectively registered on June 24, 2020. https://clinicaltrials.gov/ct2/show/NCT04448457?cond=sublingual+sufentanil&cntry=BE&draw=2&rank=3