bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-patient psychiatry management of COVID-19: rates of asymptomatic infection and on-unit transmission
Authors: Zhang Emily , LeQuesne Elizabeth , Fichtel Katherine , Ginsberg David , Frankle W. Gordon 
Published: September 2020

Background
New York City's first case of SARS-associated coronavirus (SARS-CoV-2) disease 2019 (COVID-19) was identified on 1 March 2020, prompting rapid restructuring of hospital-based services to accommodate the increasing numbers of medical admissions. Non-essential services were eliminated but in-patient treatment of psychiatric illnesses was necessarily maintained.

Aims
To detail the response of the NYU Langone Health in-patient psychiatric services to the COVID-19 outbreak from 1 March to 1 May 2020.

Method
Process improvement/quality improvement study.

Results
Over this time period, our two in-patient psychiatric units (57 total beds) treated 238 patients, including COVID-19-positive and -negative individuals. Testing for COVID-19 was initially limited to symptomatic patients but expanded over the 62-day time frame. In total, 122 SARS-CoV-2 polymerase chain reaction (PCR) tests were performed in 98 patients. We observed an overall rate of COVID-19 infection of 15.6% in the patients who were tested, with an asymptomatic positive rate of 13.7%. Although phased roll-out of testing impaired the ability to fully track on-unit transmission of COVID-19, 3% of cases were clearly identified as results of on-unit transmission.

Conclusions
Our experience indicates that, with appropriate precautions, patients in need of in-patient psychiatric admission who have COVID-19 can be safely managed. We provide suggested guidelines for COVID-19 management on in-patient psychiatric units which incorporate our own experiences as well as published recommendations.
Mammalian stress granules and P bodies at a glance
Authors: Riggs Claire L. , Kedersha Nancy , Ivanov Pavel , Anderson Paul 
Published: September 2020

ABSTRACT
Stress granules (SGs) and processing bodies (PBs) are membraneless ribonucleoprotein-based cellular compartments that assemble in response to stress. SGs and PBs form through liquid–liquid phase separation that is driven by high local concentrations of key proteins and RNAs, both of which dynamically shuttle between the granules and the cytoplasm. SGs uniquely contain certain translation initiation factors and PBs are uniquely enriched with factors related to mRNA degradation and decay, although recent analyses reveal much broader protein commonality between these granules. Despite detailed knowledge of their composition and dynamics, the function of SGs and PBs remains poorly understood. Both, however, contain mRNAs, implicating their assembly in the regulation of RNA metabolism. SGs may also serve as hubs that rewire signaling events during stress. By contrast, PBs may constitute RNA storage centers, independent of mRNA decay. The aberrant assembly or disassembly of these granules has pathological implications in cancer, viral infection and neurodegeneration. Here, we review the current concepts regarding the formation, composition, dynamics, function and involvement in disease of SGs and PBs.
In silico study on RNA structures of intronic mutations of beta-globin gene
Authors: Sumantri Nur Imaniati , Lischer Kenny , Wijayanti Dian Rachma , Abuzairi Tomy 
Published: September 2020

Background: Mutation of the beta-globin gene (HBB) interferes with primary mRNA transcription, leading to beta-thalassemia disease. The IVS1nt1 and IVS1nt5 mutations were reported as two of the most prevalent intronic mutations associated with beta-thalassemia major. These mutations may affect the mRNA structure of the human beta-globin (HBB) gene. However, the mechanism by which variation in HBB alters the mRNA structure remains unclear. The objective of this study was to unveil the secondary and tertiary conformation difference of the mutants compared to the wildtype using in silico analysis. Methods: The sequence of HBB was obtained from Ensemble database and mutated manually at nucleotides 143 (IVS1nt1G>T) and 147 (IVS1nt5G>C). The RNA secondary and tertiary structure were performed by ViennaRNA Web Services and 3dRNA v2.0, respectively. Results and Discussion: The results revealed the unique folding characteristics of each mutations for the secondary and tertiary structures. Based on the structure, unwanted folding occurred in the IVS1nt1G>T and IVS1nt5G>C mRNA structures compared to the wild-type structure. This finding was supported by the results of centroid-based analysis and RNA structure analysis, indicating that the larger loops in IVS1nt1 and IVS1nt5 result in an unstable structure. Our study found that intronic mutations affect the mRNA structure of HBB by altering its folding mechanism.
Designing an e-learning tool to support health practitioners caring for patients taking multiple medications
Authors: Hanlon Michelle , Hogan Michael , Durand Hannah , Pilch Monika , Harney Owen , Molloy Gerard , Murphy Andrew W. 
Published: September 2020

Background: Population ageing and improvements in healthcare mean the number of people living with two or more chronic conditions, or ‘multimorbidity’, is rapidly increasing. This presents a challenge to current disease-specific care delivery models. Adherence to prescribed medications appears particularly challenging for individuals living with multimorbidity, given the often-complex drug regimens required to treat multiple conditions. Poor adherence is associated with increased mortality, as well as wasted healthcare resources. Supporting medication adherence is a key priority for general practitioners (GPs) and practice nurses as they are responsible for much of the disease counselling and medication prescribing associated with chronic illnesses. Despite this, practical resources and training for health practitioners on how to promote adherence in practice is currently lacking. Informed by the principles of patient and public involvement (PPI), the aim of this research was to develop a patient informed e-learning resource to help GPs and nurses support medication adherence. Method: Utilising collective intelligence (CI) and scenario-based design (SBD) methodology, input was gathered from 16 stakeholders to gain insights into barriers to supporting people with multimorbidity who are receiving polypharmacy, strategies for overcoming these barriers, and user needs and requirements to inform the design of the e-learning tool. Results: In total, 67 barriers to supporting people who are taking multiple medications were identified across 8 barrier categories. 162 options for overcoming the identified barriers were then generated. This data was used in the design of a short and flexible e-learning tool for continuous professional development, that has been integrated into general practice and clinical education programmes as a supportive tool. Conclusions: Using CI and SBD methodology was an effective way of facilitating collaboration, idea-generation, and the co-creation of design solutions amongst a diverse group of stakeholders. This approach could be usefully applied to address other complex healthcare-related challenges.
Long-term bisphosphonate treatment coupled with ovariectomy in mice provokes deleterious effects on femoral neck fracture pattern and modifies tibial shape
Authors: Monzem Samuel , Ballester Rafael Y. , Javaheri Behzad , Poulet Blandine , Sônego Dábila A. , Pitsillides Andrew A. , Souza Roberto L. 
Published: September 2020

Aims The processes linking long-term bisphosphonate treatment to atypical fracture remain elusive. To establish a means of exploring this link, we have examined how long-term bisphosphonate treatment with prior ovariectomy modifies femur fracture behaviour and tibia mass and shape in murine bones. Methods Three groups (seven per group) of 12-week-old mice were: 1) ovariectomized and 20 weeks thereafter treated weekly for 24 weeks with 100 μm/kg subcutaneous ibandronate (OVX+IBN); 2) ovariectomized (OVX); or 3) sham-operated (SHAM). Quantitative fracture analysis generated biomechanical properties for the femoral neck. Tibiae were microCT scanned and trabecular (proximal metaphysis) and cortical parameters along almost its whole length measured. Results Fracture analyses revealed that OVX+IBN significantly reduced yield displacement (vs SHAM/OVX) and resilience, and increased stiffness (vs SHAM). OVX+IBN elevated tibial trabecular parameters and also increased cortical cross-sectional area and second moment of area around minor axis, and diminished ellipticity proximally. Conclusion These data indicate that combined ovariectomy and bisphosphonate generates cortical changes linked with greater bone brittleness and modified fracture characteristics, which may provide a basis in mice for interrogating the mechanisms and genetics of atypical fracture aetiology. Cite this article: Bone Joint Open 2020;1-9:512–519.
Proposal of Rydberg atomic receiver for amplitude-modulated microwave signals with active Raman gain
Authors: Cai Yongqi , Wang Jing , Lin Lidan , Lu Xiao , Li Yuxia , Peng Yandong 
Published: September 2020

An efficient scheme for a microwave (MW) receiver is proposed based on the active Raman gain (ARG) in Rydberg atoms. The

87

R
b

atoms are excited to the Rydberg state

(

53

D

5

/

2

)

, and the gain spectrum has a single gain peak. The MW field is resonant with the Rydberg transition

(

53

D

5

/

2

→

54

P

3

/

2

)

, resulting in a split in the gain spectrum. The frequency splitting of two peaks depends linearly on the MW field strength. The distortion and attenuation of the probe field are reduced, due to the system's operating in the stimulated Raman emission mode. Simulation results show that the fidelity of MW communication based on the Rydberg atomic ARG scheme is improved by at least 10 times compared to that based on an electromagnetically induced transparency scheme, and the system seems more robust to amplitude modulation signals with different modulation depths.
Receiving sensitivity improvement by wide-spectrum OAM with OTDM and polarization multiplexing in weak atmospheric turbulence
Authors: Yang Qiaochu , Wang Tianshu , Chen Junda , Lin Peng , Jiang Ziqi , Sun Zhiwen , Yu Ce , Sun Heyang , Jiang Huilin 
Published: September 2020

In this paper, a wide-spectrum orbital angular momentum (OAM) system with a polarization and optical time division multiplexing (OTDM) free-space transmission system is experimentally demonstrated. To enhance the system transmission performance in atmospheric turbulent channel, a wide-spectrum laser and an OAM beam are used. The wide-spectrum laser can be generated by utilizing pumped laser to pump nonlinear fiber, and OAM can be generated with a special light modulator. Furthermore, OTDM and polarization multiplexing methods are used to enhance the communication rate from 4 Gbit/s to 32 Gbit/s. With the use of the wide-spectrum laser and the OAM beam, the receiving scintillation index (SI) can be reduced, and detection sensitivity can be improved. It is the first time a wide-spectrum OAM communication system performance has been studied. It is shown that under weak atmospheric turbulence condition, the SI can be reduced by 38% and the receiving sensitivity can be improved by 3.18 dB via wide-spectrum OAM beams.
Calibration method of three-dimensional plane array laser radar based on space-time transformation
Authors: Zhang Shuo , Sun Lipeng , Chen Yongran , Bi Yong 
Published: September 2020

As a measurement system that can realize target detection and optical imaging, the accuracy of three-dimensional laser radar is a main performance index, which makes calibration an extremely important work. Traditional calibration methods have many disadvantages, such as harsh environment requirements, complex and tedious calibration processes, and inaccurate calibration results. To solve these problems, we propose a calibration method so that the relative position of the cooperative target and the detection sensor is fixed. The principle of space-time transform is used to simulate distance, and the synchronous control of distance is realized by controlling the delay module. In addition, a simple and practical calibration device is designed. In the actual measurement, the average absolute error is 0.0019 m, and the relative error is 0.0678% in the range of 0.5–25 m. The experimental results show that this method is stable and accurate, and it can calibrate the plane array laser radar quickly and accurately.
11  W YLF-based intra-cavity pumped Ho laser with near diffraction limited beam quality
Authors: Huang Haizhou , Hu Huawen , Deng Jing , Li Jinghui , Zhang Jiangdian , Zheng Hui , Lin Wenxiong 
Published: September 2020

We develop a fluoride-based intra-cavity pumped Ho laser for the first time, where the severe thermal lensing of the intra-cavity pumping mechanism can be compensated by the negative thermal-optical property of the

Y
L
i

F

4

(YLF) host. A maximum output power of 11.3 W (

π

-pol) at 2062 nm, corresponding to a conversion efficiency of 28.2% from the incident diode laser to the Ho laser, was obtained with a power instability below 0.5% and a near diffraction limited beam quality with

M
2

of 1.06 and 1.25 in the horizontal and vertical directions, respectively. These are the maximum power and the best beam quality for the reported compact intra-cavity pumped Ho lasers, to the best of our knowledge.
Fasting Plasma Glucose Variability and Gastric Cancer Risk in Individuals Without Diabetes Mellitus: A Nationwide Population-Based Cohort Study
Authors: Hong So-hyeon , Noh Eunjin , Kim Jinsil , Hwang Soon Young , Kim Jun A. , Lee You-Bin , Roh Eun , Choi Kyung Mook , Baik Sei Hyun , Cho Geum Joon , Yoo Hye Jin 
Published: September 2020

INTRODUCTION:
Long-term glycemic variability is associated with various adverse health outcomes in patients with diabetes mellitus (DM). However, the relationship between glycemic variability and gastric cancer remains unclear. We aimed to investigate the association between glycemic variability and gastric cancer incidence in individuals without DM.

METHODS:
We used the Korean National Health Insurance Service data sets of claims and health checkups and included 202,562 individuals without DM. Fasting plasma glucose (FPG) variability was measured using the variability independent of the mean (VIM), coefficient of variation, SD, and average successive variability. The association between FPG variability and gastric cancer incidence was analyzed using Cox regression adjusting for age, sex, body mass index, smoking status, alcohol consumption, regular exercise, income level, family history of cancer, mean FPG level, and number/mean interval of FPG measurements.

RESULTS:
In total, 1,920 patients developed gastric cancer (0.95%) within a median follow-up of 5.6 (5.3, 6.4) years. The fully adjusted hazard ratio and 95% confidence interval for gastric cancer were 1.26 and 1.18–1.34, respectively, in the highest quartile of FPG variability assessed by VIM compared with that in the lowest quartile. Similar results were obtained in the normal and impaired fasting glucose groups and when using the variability indexes, including coefficient of variation, SD, and average successive variability. There was a sequential increase in the incidence of gastric cancer according to the increase in the deciles of FPG variability (P for linear trend <0.001). A 1-SD increase in FPG variability assessed by VIM was significantly associated with a 10.0% increase in gastric cancer risk in the fully adjusted model.

DISCUSSION:
In a DM-free population, high variability in visit-to-visit FPG levels was independently associated with an increased risk of gastric cancer.
Validation of the Polar Team Pro System for Sprint Speed With Ice Hockey Players
Authors: Conners Ryan T. , Whitehead Paul N. , Dodds Fitzgerald T. , Schott Kinta D. , Quick Madison C. 
Published: September 2020

Abstract
Conners, RT, Whitehead, PN, Dodds, FT, Schott, KD, and Quick, MC. Validation of the polar team pro system for sprint speed with ice hockey players. J Strength Cond Res 36(12): 3468–3472, 2022—Commercially available player tracking sensors such as the Polar Team Pro system (PTPS) have been used to monitor athlete performance. Use during ice hockey practices and games has resulted in seemingly plausible and valid values for internal metrics (heart rate); however, external metrics (distance, speed, and acceleration) seem sporadic and counterintuitive. To determine the validity of the PTPS for measuring sprint speed with collegiate hockey players, 15 NCAA Division I male athletes (21.86 ± 1.04 years, 175.86 ± 6.78 cm, 80.58 ± 4.44 kg) participated in the study. Subjects wore a PTPS strap, at the level of the xiphoid process, and performed 2 sprints of 15.24 m (blue line to blue line) and 35.05 m (red line to the far blue line) in 3 conditions: indoor ice skating, indoor running, and outdoor running. Timing gates (TG) were used to determine sprint times, which allowed for manual calculation of speed. Speed values from the PTPS and TG were compared using paired-samples t-tests, and an alpha level of 0.05, 2-sided, was set a priori as a significance level. For indoor ice skating, PTPS significantly underestimated speeds at both distances (p < 0.001). However, PTPS significantly overestimated speeds for indoor and outdoor sprints at both distances (p ≤ 0.001). The PTPS is not accurate for measuring short-distance linear sprint speed or linear sprint speed during indoor ice skating. The inconsistency in speed values needs to be taken into consideration when using the system for science-based training because inaccurate speed values may negatively affect other external performance metrics provided by PTPS.
Preconditioning Strategies Before Maximum Clean Performance in Female Weightlifters
Authors: Kelekian Georgia-Kassandra , Zaras Nikolaos , Stasinaki Angeliki-Nikoletta , Spiliopoulou Polyxeni , Karampatsos Giorgos , Bogdanis Gregory , Terzis Gerasimos 
Published: September 2020

Abstract
Kelekian, GK, Zaras, N, Stasinaki, AN, Spiliopoulou, P, Karampatsos, G, Bogdanis, G, and Terzis, G. Preconditioning strategies before maximum clean performance in female weightlifters. J Strength Cond Res 36(8): 2318–2321, 2022—The aim of the study was to examine the acute effect of performing clean pulls with either 85% or 120% one repetition maximum (1RM), on subsequent clean performance, in female Olympic weightlifters. Eight competitive female Olympic weightlifters (age, 22.9 ± 5.8 years; height, 1.67 ± 0.06 m; training experience, 6.1 ± 3.9 years; clean performance, 66.3 ± 3.9 kg), performed clean pulls either with 85% or with 120% 1RM, 3 minutes before their maximum effort in clean, in 2 different days, in a counterbalanced order. The rate of perceived exertion (RPE) was provided after each intervention. Body composition (dual x-ray absorptiometry), countermovement jumping (CMJ) performance, leg press isometric rate of force development (RFD), and peak force (PF) were also evaluated on different days. Clean performance was increased by 6.1 ± 3.6% (p = 0.002) after preconditioning with 85% 1RM and 4.7 ± 3.1% (p = 0.004) after 120% 1RM. Rate of perceived exertion was lower after preconditioning with 85% 1RM, compared with 120% 1RM (p = 0.015). No significant correlation was found between the changes in clean performance after 85% or 120% 1RM, with lean body mass, CMJ performance, and isometric leg press RFD, and leg press PF. These data suggest that lifting either 85% or 120% 1RM in clean pulls is an effective strategy for acute increase of clean performance in female Olympic weightlifters, whereas the use of 85% 1RM load may be performed with less exertion.
A Qualitative Exploration of the Impact of a Distressed Family Member on Pediatric Resuscitation Teams
Authors: Deacon Amanda , O’Neill Tom , Delaloye Nicole , Gilfoyle Elaine 
Published: September 2020

BACKGROUND AND OBJECTIVES:Family presence during resuscitation (FPDR) is commonplace in many hospitals today. Research has supported the positive effects it can have on family members; however, there is little research about how it may affect the resuscitation team’s performance, especially in a pediatric population. Our objective was to identify how resuscitation team members perceive and respond to the presence of a distressed family member during a resuscitation.METHODS:This is a qualitative study in which we examine FPDR-related themes raised by pediatric resuscitation team members after a resuscitation simulation. As part of a team training educational intervention, pediatric resuscitation teams, composed of nurses, respiratory therapists, and resident physicians, participated in a video-recorded simulated event in which they attempted to resuscitate an infant. During the scenario, a confederate actor played the role of a distressed “parent.” Video-recorded debriefs occurred immediately after each simulation. Video recordings were transcribed verbatim, and then transcripts were coded and analyzed via thematic analysis to saturation.RESULTS:Thirteen postevent video debriefs were analyzed. A total of 74 participants took part in these simulations and debriefs. Analysis revealed 15 major and 29 minor themes, which were mapped to 5 factors, namely resuscitation environment, affective responses, cognitive responses, behavioral responses, and team dynamics.CONCLUSIONS:FPDR has an impact on resuscitation team members’ responses and influences their adaptive behavior. If not managed well, this may pose potential patient safety concerns. Policy and training of specific teamwork skills are ways in which we can better equip health care providers to effectively manage FPDR.
A teaching based technology in geography learning
Authors: Kurniawan Edi , Eva Banowati , Dafip Muchamad , S Sriyanto 
Published: September 2020

This study aims to identify the ability of teachers to use technology and teacher competencies towards technology-based learning processes. This research involved 35 high school geography teachers in Semarang City. Variables analyzed include technological skill (TS); pedagogic competence (PED); professional competence (PRO); and technology-based learning (TBT) developed by teachers. The questionnaire was used in this research was closed questionnaire model. The collected data was tabulated and continued with Kolmogorov-Smirnov test, ANOVA test, Pearson correlation test and regression test. Based on the result, teacherâ€™s capability in using technology, has no connection with the technology-based learning that designed by them. While professional competency has no significant impact on the implementation of TBT (p = 0.801), with a partial negative value and R2 of only 4%. It can be assumed that the technology-based learning was conducted based more on the ability of teachers to manage class and learning, rather than developing learning technology. Technology-based geography learning compiled by respondents is based more on the ability to manage classrooms and learning rather than developing learning technology. Based on the result, we recoment to stakeholders to facilitate teacher by providing technology training, instruments before moving to technology based teaching, and socialization.

Keywords : pedagogic competence, teaching technology, technology skill