bluuebunny/crossref_metadata_2025_split huggingface dataset:
ASSOCIATION OF VITREORETINAL LYMPHOMA WITH SYSTEMIC LYMPHOMA
Authors: Mashayekhi Arman , Dalvin Lauren A. , Lim Li-Anne S. , Ancona-Lezama David , Mazloumi Mehdi , Chang Michael , Shields Carol L. , Shields Jerry A. 
Published: May 2020

Purpose:
To determine the association between vitreoretinal lymphoma and systemic lymphoma (SL).

Methods:
Single-center retrospective review of medical records.

Results:
Of 95 patients with vitreoretinal lymphoma, 18 (19%) had associated SL (SL group) and 77 (81%) were not associated with SL (no SL group). The most common sites of SL were skin (n = 5), testis (n = 2), liver and breast (n = 2), and others (n = 9). A comparison (SL group vs. [vs.] no SL group) revealed no difference in demographic or ocular findings at initial visit. In the SL group, SL occurred before the onset of ocular symptoms in 14 (78%) patients with mean interval of 86 months (median 61, range 5–286 months) or after ocular symptoms in 4 (22%) patients with mean interval of 19 months (median 12, range 7–44 months). A comparison revealed no difference in overall frequency of pre-existing or eventual central nervous SL (50% vs. 53%, P = 0.99); however, the SL group demonstrated central nervous SL more often after onset of ocular symptoms (78% vs. 17%, P = 0.001). A comparison found no difference in treatment methods, response of vitreoretinal lymphoma to treatment, final visual outcome, or death rate.

Conclusion:
We found 19% of patients with vitreoretinal lymphoma demonstrate related SL, and there was no difference in demographics, clinical features, or response to treatment, compared to those not associated with SL.
STELLATE UNILATERAL NONHEREDITARY IDIOPATHIC FOVEOMACULAR RETINOSCHISIS: A MULTIMODAL IMAGING ANALYSIS AND CASE REPORT
Authors: Montano Margarita , Alfaro D. Virgil , Quiroz-Reyes Miguel A. , Lima-Gómez Virgilio , Bonilla Luisa A. , Chew-Bonilla Alan , Monares-Zepeda Gerardo 
Published: May 2020

Purpose:
To describe a case of stellate nonhereditary idiopathic foveomacular retinoschisis in a middle-aged woman and to depict the classic retinal fluorangiography (FA) findings, structural characteristics using macular spectral-domain optical coherence tomography angiographic data of vascular and perfusion density using optical coherence tomography angiography (OCT-A), and standardized multifocal electroretinography (mfERG) findings.

Methods:
This is a case report of a 53-year-old ophthalmologist who was incidentally diagnosed with unilateral idiopathic foveomacular retinoschisis. Stellate nonhereditary idiopathic foveomacular retinoschisis is defined as a foveal elevation without alternative explanation for retinoschisis. FA, spectral-domain optical coherence tomography, optical coherence tomography angiography, and multifocal electroretinography were used as tools to obtain an integral multimodal diagnosis of this entity.

Results:
Clinical examination and multimodal imaging were able to detect unilateral idiopathic retinoschisis, revealing a stellate pattern of retinal concentric cysts with minimal changes in vascular and perfusion density metrics and confirming the absence of bridging vessels. There were consistent FA findings, with almost unaltered foveal changes. Multifocal electroretinography depicted a subtle reduction in dark-adapted a-wave and b-wave amplitudes.

Conclusion:
Improvements and innovations in technology for ophthalmic diagnosis have revolutionized our capacity for diagnostic decision-making. Spectral-domain optical coherence tomography and optical coherence tomography angiography are useful tools for diagnosis and follow-up assessment. This fortuitous case gives a window on the importance of a routine specialized ophthalmic examination and how multimodal imaging can depict important and specific findings not evident from a clinical point of view. The subtle but important changes observed in optical coherence tomography angiography and multifocal electroretinography will help better define this clinical entity.
Comparison of 1-Year Effectiveness of Trabecular Microbypass Stent implantation (iStent) in Conjunction With Phacoemulsification Among Mild, Moderate, and Severe Primary Open-angle Glaucoma Patients
Authors: Chansangpetch Sunee , Ittarat Mantapond , Yang Shuo , Fisher Ann C. , Singh Kuldev , Lin Shan C. , Chang Robert T. 
Published: May 2020

Precis:The study compared 1-year effectiveness of single trabecular microbypass stent (iStent) implantation with phacoemulsification among glaucoma severities in primary open-angle glaucoma. The study found that mild glaucoma had greater success rate and lower number of medications compared with moderate and severe glaucoma.Purpose:To evaluate the effectiveness of iStent implantation in combination with cataract surgery in moderate to severe glaucoma compared with mild glaucoma.Methods:Medical charts of primary open-angle glaucoma subjects undergoing 1 iStent implantation were retrospectively reviewed. Glaucoma was classified on the basis of mean deviation (MD) of the preoperative standard automated perimetry into mild (MD>−6 dB), moderate (MD −6 to −12 dB), and severe (MD<−12 dB). Mixed effect regression models were performed to determine the effect of iStent at 1 year. The outcomes included as follows: (1) intraocular pressure (IOP) and the number of medications, (2) eyes with IOP ≤ severity-based target (18 mm Hg for mild, 15 mm Hg for moderate, 12 mm Hg for severe) (2A) without medication, and (2B) with medication reduction.Results:In total, 104 eyes from 89 subjects were analyzed. Cataract combined with iStent surgery significantly lowered the number of medications in all groups and significantly decreased IOP in moderate and severe glaucoma (P<0.05). There was significantly higher number of medications in moderate (β: 0.58,P=0.002) and severe (β: 1.20,P<0.001) compared with mild glaucoma. Eyes with moderate glaucoma had significantly lower rate of success (criterion 2A) compared with mild glaucoma [odds ratio (OR): 0.008,P=0.047]. Eyes with moderate and severe glaucoma had significantly lower rates of success (criterion 2B) (moderate vs. mild OR: 0.002,P=0.028; severe vs. mild OR: 0.026,P=0.026).Conclusions:Combined phacoemulsification with iStent seems to have a better IOP-lowering and medication-lowering effect in mild glaucoma cases versus those with moderate and severe glaucoma. This difference was found in real-world data over one-year follow-up period. Long-term studies with defined IOP goals and medication removal protocols are warranted.
Tanezumab for chronic low back pain: a randomized, double-blind, placebo- and active-controlled, phase 3 study of efficacy and safety
Authors: Markman John D. , Bolash Robert B. , McAlindon Timothy E. , Kivitz Alan J. , Pombo-Suarez Manuel , Ohtori Seiji , Roemer Frank W. , Li David J. , Viktrup Lars , Bramson Candace , West Christine R. , Verburg Kenneth M. 
Published: May 2020

Abstract
This randomized, double-blind, phase 3 study (56-week treatment; 24-week follow-up) assessed tanezumab in patients with chronic low back pain and history of inadequate response to standard-of-care analgesics (NCT02528253). Patients received placebo, subcutaneous tanezumab (5 or 10 mg every 8 weeks), or oral tramadol prolonged-release (100-300 mg/day). Primary endpoint was change in low back pain intensity (LBPI) at week 16 for tanezumab vs placebo. Key secondary endpoints were proportion of patients with ≥50% decrease in LBPI at week 16, change in Roland Morris Disability Questionnaire at week 16, and change in LBPI at week 2 for tanezumab vs placebo. Adverse events and joint safety were assessed through weeks 56 and 80, respectively. Tanezumab 10 mg met the primary endpoint by significantly improving LBPI at week 16 vs placebo; least squares (LS) mean (95% CI) difference = −0.40 (−0.76 to −0.04; P = 0.0281). Tanezumab 10 mg significantly improved all key secondary endpoints. Tanezumab 5 mg did not meet the primary endpoint (LS mean [95% CI] treatment difference vs placebo = −0.30 [−0.66 to 0.07; P = 0.1117]), preventing formal testing of key secondary endpoints for this dose. The proportion of patients with ≥50% improvement in LBPI at week 16 was 37.4% in the placebo group, 43.3% in the tanezumab 5 mg group (Odds ratio [95% CI] vs placebo = 1.28 [0.97 to 1.70; P = 0.0846]), and 46.3% in the tanezumab 10 mg group (Odds ratio [95% CI] vs placebo = 1.45 [1.09 to 1.91; P = 0.0101]). Prespecified joint safety events were more frequent with tanezumab 10 mg (2.6%) than tanezumab 5 mg (1.0%), tramadol (0.2%), or placebo (0%). Seven patients, all in the tanezumab 10 mg group (1.4%), underwent total joint replacement. In conclusion, tanezumab 10 mg significantly improved pain and function vs placebo in patients with difficult-to-treat chronic low back pain. Tanezumab was associated with a low rate of joint safety events, some requiring joint replacement.
Social Perception Predicts Awareness of Illness in Persons With Schizophrenia
Authors: Feyer Frida K. , Andersson Stein , Büchmann Camilla B. , Melle Ingrid , Andreassen Ole A. , Vaskinn Anja 
Published: May 2020

Abstract
Lack of clinical insight in patients with schizophrenia is an obstacle to optimal treatment. Social cognition is one of several variables central to insight deficits in schizophrenia. The aim of this study was to investigate clinical insight in relation to one domain of social cognition, social perception, while controlling for effects of nonsocial cognition and symptom severity. Clinical insight was measured in 55 patients with schizophrenia or schizoaffective disorder, using the Birchwood Insight Scale. Relationships across domains were used to assess social perception. Social perception predicted one of three subscales of clinical insight, “awareness of illness,” and was the only unique contributor to this subscale. This indicates that social perception is linked to clinical insight through awareness of illness. More research is needed to fully understand the relationship between social and nonsocial cognition and symptoms in relation to clinical insight.
Exploring Practices of Bedside Shift Report and Hourly Rounding. Is There an Impact on Patient Falls?
Authors: Sun Carolyn , Fu Caroline J. , O'Brien Jessica , Cato Kenrick D. , Stoerger Lauren , Levin Alan 
Published: May 2020

OBJECTIVE
To describe the relationship of inpatient falls to bedside shift report (BSR) and hourly rounding (HR).

BACKGROUND
Falls are a major healthcare concern. Although measures such as BSR and HR are reported to reduce falls, studies are often based on self-reported data related to nurse compliance with protocols for HR and bedside report.

METHODS
Observational data were collected on nursing tasks, including BSR and HR.

RESULTS
Nine thousand six hundred ninety-three observations were recorded on 11 units at 4 hospitals over 281 shifts. Falls were associated with shift and day of the week but not BSR, HR, or the frequency of encounters with the patient. The regression model included frequency with patient, shift, day of week, and HR.

CONCLUSIONS
Increased nurse frequency with patient may signal increased fall risks. Bedside shift report and HR may require robust and sustained interventions to provide lasting effects.
Using Objective Structured Clinical Examination as a Teaching Tool in a Hybrid Advanced Health Assessment Course
Authors: Champlin Andrea M. , Roberts Lisa R. , Pueschel Robin D. , Saunders Jasmine S.D. , Huerta Gloria M. , Yang Joanna 
Published: May 2020

Background
Advanced health assessment is a required course in advanced practice RN (APRN) education, essential to providing the foundation for differential diagnosis (DD) skills and the ability to formulate a plan of care.

Problem
Feedback from clinical preceptors revealed that our doctor of nursing practice (DNP) students struggled to make a DD.

Approach
This educational quality improvement project collected data from 7 cohorts of DNP students in either the Family Nurse Practitioner or Adult Gerontology Nurse Practitioner program to evaluate their readiness for clinical practicums and to inform necessary curriculum revisions.

Outcomes
Data revealed that students' ability to identify 3 DDs correctly during the summative health assessment objective structured clinical examination was inconsistent. Qualitative data revealed students lacked understanding on how to use results from the physical assessment to formulate a DD.

Conclusion
The findings of this project corroborate those from the literature that suggest we should teach APRN students DD skills explicitly.
Resident Trainees Increase Surgical Time: A Comparison of Obstetric and Gynaecologic Procedures in Academic Versus Community Hospitals
Authors: McGee Jacob , Winick-Ng Jennifer , McClure J. Andrew , Penava Deborah , Lovett Erin , Vinden Chris , McKeown Megan 
Published: May 2020

(Abstracted from J Obstet Gynaecol Can 2020;42:430–438)
Obstetrics and gynecology residents experience a myriad of professional competency and growth by performing procedures in operative rooms. Canadian residents in obstetrics/gynecology (OB/GYN) undergo 5 years of training at teaching hospitals and have the opportunity to assist with many common surgical procedures.
Adverse Birth Outcomes and Birth Telomere Length: A Systematic Review and Meta-analysis
Authors: Niu Zhongzheng , Li Karen , Xie Chuanbo , Wen Xiaozhong 
Published: May 2020

(Abstracted from J Pediatr 2019;215:64–74)
Fetal growth restriction (FGR) and preterm birth are associated with an increase in morbidity and mortality during infancy. Growth-restricted and preterm newborns are also at an increased risk of developing obesity, hypertension, non–insulin-dependent diabetes, and atherosclerosis later in life.
Hydrocarbon Intoxication in Children
Authors: Tenenbaum Ariel , Rephaeli Rotem , Cohen-Cymberknoh Malena , Aberbuch Diana , Rekhtman David 
Published: May 2020

Objectives
Hydrocarbon intoxication in children still occurs, although it is preventable. It may cause a variety of clinical manifestations, involving the respiratory system and the nervous system. Our goal was to investigate all cases of hydrocarbon poisoning in children hospitalized in the Hadassah-Hebrew university hospitals in Jerusalem due to exposure to hydrocarbon in 2 decades.

Methods
We retrieved the clinical and sociodemographic characteristics of all children who were admitted to our hospitals because of hydrocarbon intoxication in 2 decades.

Results
One hundred seventy-two children were hospitalized, primarily because of ingestion of kerosene. In most cases, the poisons were stored in a bottle or other easily accessible container. Boys were more likely than girls to be hospitalized. Most of the children were of Arab origin in families with more than 3 children. Coughing, vomiting, and a decrease in conscious state were common at presentation, followed by fever and dyspnea. The clinical course was usually mild to moderate and self-resolving. Some children were treated with oxygen, fluids, and antibiotics. The main result of hydrocarbon poisoning was chemical pneumonitis, and many had pathological chest x-rays. Only one severe case resulted in death.

Conclusions
Hydrocarbon intoxication results in a variety of clinical manifestations and can be life-threatening. Most cases of poisoning could have been easily prevented if the substances were kept out of the reach of children.
Response to COVID-19: Minimizing Risks, Addressing Challenges and Maintaining Operations in a Complex Academic Radiology Department
Authors: Pedrosa Ivan , Browning Travis , Kwon Jeannie K. , Morriss Michael , Matsler Lacy , Pinho Marco C. , Lamus Daniel , Pillai Anil , Karow Sweta Patel , Garinn Jon , Brewington Cecelia , Zeikus Eric , Rofsky Neil M. 
Published: May 2020

Abstract
The coronavirus disease 2019 (COVID-19) pandemic has necessitated rapid response plans to minimize risks of infection in the workforce while ensuring maintenance of essential functions of radiology departments. Plan adoption is, however, challenged by the need to coordinate with institutional efforts, a rapidly expanding number of patients, and the diversity of clinical and administrative functions in the department. Here, we describe the implementation of a response plan in an academic radiology department, challenges encountered, and tactics used to address these challenges.
Low-Grade Myofibroblastic Sarcoma Demonstrated on 99mTc-MDP Bone Scan and 18F-FDG PET/CT
Authors: Hou Wenxiu , Su Minggang , Li Qianrui , Tian Rong 
Published: May 2020

Abstract
A 24-year-old woman with left hip pain for 4 months was admitted. Radiographs of the left hip showed a radiolucent lesion in the proximal femur. The lesion demonstrated hypointensity on T1-weighted and high intensity on T2-weighted fat saturated images. 99mTc-MDP bone scan and 18F-FDG PET/CT illustrated intense radiotracer accumulation at the osteolytic lesion. Postoperative pathology confirmed a low-grade myofibroblastic sarcoma (LGMS). LGMS is a rare neoplasm, which often occurred in the head and neck region. Our case suggested that LGMS should be considered in the differential diagnosis of proximal femur lesion on 99mTc-MDP bone scan and 18F-FDG PET/CT.
68Ga-DOTATATE Uptake in an Endolymphatic Sac Tumor
Authors: Lou Robert , Lazor Jillian W. , Baraban Ezra , Ware Jeffrey B. , Cooper Kumarasen , Pantel Austin R. 
Published: May 2020

Abstract
After dedicated CT and MRI, 68Ga-DOTATATE PET/CT was performed in a patient with a temporal bone mass with primary diagnostic considerations of an endolymphatic sac tumor versus a glomus jugulotympanicum paraganglioma. The 68Ga-DOTATATE PET showed mild radiotracer uptake in the mass (SUVmax, 10.9). After surgical resection, pathology revealed an endolymphatic sac tumor. Immunohistochemical staining demonstrated somatostatin receptor type 2A expression in the vasculature of the mass, but not in the tumor cells.
Laboratory-Proven Asymptomatic SARS-CoV-2 (COVID-19) Infection on 18F-FDG PET/CT
Authors: Krebs Simone , Petkovska Iva , Ho Alan L. , Ulaner Gary A. 
Published: May 2020

Abstract
An 87-year-old man with primary salivary duct carcinoma and hepatic metastases was referred for restaging. 18F-FDG PET/CT demonstrated new FDG-avid ground-glass opacities with intralobular septal thickening in both lungs with a peripheral dominant distribution. This was interpreted as a pattern highly suggestive of COVID-19 pneumonia, and the referring physician was contacted. The patient was currently asymptomatic and without clinical evidence of active pneumonia. However, the patient tested positive for COVID-19 using real-time reverse transcription–polymerase chain reaction. This case demonstrates that even asymptomatic outpatients undergoing PET/CT should be evaluated for radiologic findings suggestive of COVID-19 during this pandemic.
Does End-Expiratory Occlusion Test Predict Fluid Responsiveness in Mechanically Ventilated Patients? A Systematic Review and Meta-Analysis
Authors: Si Xiang , Song Xiaodong , Lin Qiwen , Nie Yao , Zhang Guanrong , Xu Hailin , Chen Minying , Wu Jianfeng , Guan Xiangdong 
Published: May 2020

ABSTRACT

Background:
We performed a systematic review and meta-analysis of studies investigating the end-expiratory occlusion (EEO) test induced changes in cardiac index (CI) and in arterial pressure as predictors of fluid responsiveness in adults receiving mechanical ventilation.

Methods:
MEDLINE, EMBASE, Cochrane Database, and Chinese database were screened for relevant original and review articles. The meta-analysis determined the pooled sensitivity, specificity, diagnostic odds ratio, area under the receiver operating characteristic curve (AUROC), and threshold for the EEO test assessed with CI and arterial pressure. In addition, heterogeneity and subgroup analyses were performed.

Results:
We included 13 studies involving 479 adult patients and 523 volume expansion. Statistically significant heterogeneity was identified, and meta-regression indicated that prone position was the major sources of heterogeneity. After removal of the study performed in prone position, heterogeneity became nonsignificant. EEO-induced changes in CI (or surrogate) are accurate for predicting fluid responsiveness in semirecumbent or supine patients, with excellent pooled sensitivity of 92% (95% CI, 0.88–0.95, I2 = 0.00%), specificity of 89% (95% CI, 0.83–0.93, I2 = 34.34%), and a summary AUROC of 0.95 (95% CI, 0.93–0.97). The mean threshold was an EEO-induced increase in CI (or surrogate) of more than 4.9 ± 1.5%. EEO test exhibited better diagnostic performance in semirecumbent or supine patients than prone patients, with higher AUROC (0.95 vs. 0.65; P < 0.001). In addition, EEO test exhibited higher specificity (0.93 vs. 0.83, P < 0.001) in patients ventilated with low tidal volume compared with normal or nearly normal tidal volume. However, EEO test was less accurate when its hemodynamic effects were detected on arterial pressure. EEO-induced changes in arterial pressure exhibited a lower sensitivity (0.88 vs. 0.92; P = 0.402), specificity (0.77 vs. 0.90; P = 0.019), and AUROC (0.87 vs. 0.96; P < 0.001) compared with EEO-induced changes in CI (or surrogate).

Conclusions:
EEO test is accurate to predict fluid responsiveness in semirecumbent or supine patients but not in prone patients. EEO test exhibited higher specificity in patients ventilated with low tidal volume, and its accuracy is better when its hemodynamic effects are assessed by direct measurement of CI than by the arterial pressure.
Sepsis Activates the TLR4/MyD88 Pathway in Schwann Cells to Promote Infiltration of Macrophages, Thereby Impeding Neuromuscular Function
Authors: Ye Wanlin , Liu Xueru , Bai Yiping , Tang Ni , Wu Gangming , Wang Xiaobin , Cheng Jinyuan , Liu Li 
Published: May 2020

ABSTRACT

Introduction:
Sepsis is a kind of maladjustment response to bacterial infection and activation of coagulation, which can induce neuromuscular dysfunction. However, there is scarce of experimental evidence about the relationship between Schwann cells (SCs) and sepsis in neuromuscular dysfunction. We therefore set out to identify the potential role of SCs in sepsis-induced neuromuscular dysfunction and to explore the underlying molecular mechanism.

Methods:
Primary SCs were isolated from the left hind limb sciatic nerve of sepsis mice, which was constructed by cecal ligation and puncture. Then, the SCs were infected with adenovirus encoding toll-like receptor 4 (TLR4), MyD88, or IL-1R (with lipopolysaccharide stimulation), and the Raw 264.7 macrophages were injected with adenovirus with CCR2 silencing (with mMCP-1 stimulation). Further investigation of the interleukin 1 beta (IL-1β) and macrophage cationic peptide 1 (MCP-1) expressions, we followed reverse transcription-quantitative polymerase chain reaction and enzyme-linked immunosorbent assay techniques, the F4/80 and Ki67 expressions was observed by immunofluorescence staining, while the expressions of CCR2, FAK/p-FAK, nuclear factor-κB (NFκB)/p-NFκB, and ERK1/2/p-ERK1/2 were determined by Western blot analysis. Last, but not the least, the cell migration ability and cell proliferation ability were detected by Transwell assay and Flow cytometry respectively.

Results:
Our results showed that in sepsis mice, the TLR4/MyD88/ERK pathway was activated in SCs, which triggered the cells to secrete IL-1β and MCP-1. The secreted IL-1β bound with IL-1β receptor on the surface of SCs, thereby activating the IL-1β/IL-1R/MyD88/ERK pathway and further promoting the secretion of MCP-1 by SCs. MCP-1 was found to bind to CCR2 on the surface of Raw264.7 macrophages to activate the TLR4/MyD88/ERK pathway which caused the inhibition of neuromuscular function.

Conclusion:
Sepsis significantly promotes the infiltration of macrophages by activating the TLR4/MyD88 pathway in SCs, thereby impeding neuromuscular function. Consistently, our study provides a novel concept in the area of neuromuscular dysfunction therapeutics following sepsis.