bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment with mogamulizumab or lenalidomide for relapsed adult T‐cell leukemia/lymphoma after allogeneic hematopoietic stem cell transplantation: The Nagasaki transplant group experience
Authors: Sakamoto Hikaru , Itonaga Hidehiro , Sawayama Yasushi , Furumoto Takafumi , Fujioka Machiko , Chiwata Masahiko , Toriyama Eo , Kasai Sachie , Nakashima Jun , Horai Makiko , Kato Takeharu , Sato Shinya , Ando Koji , Taguchi Jun , Imaizumi Yoshitaka , Yoshida Shinichiro , Hata Tomoko , Moriuchi Yukiyoshi , Miyazaki Yasushi 
Published: January 2020

AbstractMogamulizumab (Mog) and lenalidomide (Len) are new therapeutic candidates for relapsed adult T‐cell leukemia/lymphoma after allogeneic hematopoietic stem cell transplantation (allo‐HSCT). In the present study, we retrospectively analyzed 12 patients who received Mog or Len monotherapy for relapsed ATL after allo‐HSCT. Eight and three patients received Mog and Len, respectively. The remaining patient received Mog for the first relapse and Len for the third relapse. A complete response was achieved by three and two patients who received Mog and Len, respectively, two and one of whom remained alive with a complete response for more than 20 months. In terms of adverse events, the emergence or progression of graft‐versus‐host disease was observed in three out of four patients treated with Len and in none of the patients treated with Mog. The development or progression of cytomegalovirus reactivation was detected in four out of eight patients treated with Mog and in none of those treated with Len. The present results suggest that Mog and Len would be promising treatment options for relapsed ATL after allo‐HSCT and need to be selected based on adverse event profiles.
An enhanced rainfall–runoff model with coupled canopy interception
Authors: Tao Wanghai , Wang Quanjiu , Guo Li , Lin Henry , Chen Xiaopeng , Sun Yan , Ning Songrui 
Published: January 2020

AbstractThe translation of rainfall to runoff is significantly affected by canopy interception. Therefore, a realistic representation of the role played by vegetation cover when modelling the rainfall–runoff system is essential for predicting water, sediment, and nutrient transport on hillslopes. Here, we developed a new mathematical model to describe the dynamics of interception, infiltration, and overland flow on canopy‐covered sloping land. Based on the relationship between rainfall intensity and the maximum interception rate, the interception process was modelled under two simplified scenarios (i.e., re ≤ Intm and re > Intm). Parameterization of the model was based on consideration of both vegetation condition and soil properties. By analysing the given examples, we found that Intm reflects the capacity of the canopy to store the precipitation, k reveals the ability of the canopy to retain the intercepted water, and the processes of infiltration and runoff generation are impacted dramatically by Intm and k. To evaluate the model, simulated rainfall experiments were conducted in 2 years (2016 and 2017) across six cultivation plots at Changwu State Key Agro‐Ecological Experimental Station of the Chinese Loess Plateau. The parameters were obtained by fitting the unit discharge (simulated rainfall experiments in 2016) using the least squares method, and estimation formulas for parameters pertaining to vegetation/soil factors (measured in 2016) were constructed via multiple nonlinear regressions. By matching the simulated results and unit discharge (simulated rainfall experiments in 2017), the validity of the model was verified, and a reasonable precision (average R2 = .86 and average root mean square error = 6.45) was obtained. The model developed in this research creatively incorporates the canopy interception process to complement the modelling of rainfall infiltration and runoff generation during vegetation growth and offers an improved hydrological basis to analyse matter transport during rainfall events.
Using long short‐term memory neural networks to analyze SEC 13D filings: A recipe for human and machine interaction
Authors: Aydogdu Murat , Saraoglu Hakan , Louton David 
Published: January 2020

SummaryWe implement an efficient methodology for extracting themes from Securities Exchange Commission 13D filings using aspects of human‐assisted active learning and long short‐term memory (LSTM) neural networks. Sentences from the ‘Purpose of Transaction’ section of each filing are extracted and a randomly chosen subset is labelled based on six filing themes that the existing literature on shareholder activism has shown to have an impact on stock returns. We find that an LSTM neural network that accepts sentences as input performs significantly better, with precision of 77%, than an alternately specified neural network that uses the common bag of words approach. This indicates that both sentence structure and vocabulary are important in classifying SEC 13D filings. Our study has important implications, as it addresses the recent cautions raised in the literature that analysis of finance and accounting‐related text sources should move beyond bag‐of‐words approaches to alternatives that incorporate the analysis of word sense and meaning reflecting context.
Evolutionary conflict and coloniality in animals
Authors: Blackstone Neil W. 
Published: January 2020

AbstractDespite considerable interest in the effects of evolutionary conflict in colonies of social insects, relatively little attention has been paid to this issue in clonal animals with modular construction, such as colonial ascidians, bryozoans, and cnidarians. These colonial animals are structural individuals, subdivided into repeated morphological modules, which can individually acquire, process, and share resources. While size‐related selection favors colony formation, evolutionary conflicts remain a potent obstacle to such cooperation. These conflicts can occur at several levels and must be mediated for cooperation to emerge. Module‐level conflicts potentially result in coalitions of genetically similar modules failing to share resources or monopolizing reproduction. Mediation occurs by a number of mechanisms including: (a) a single‐module bottleneck at the initiation of colony formation, (b) allorecognition that limits colony fusion to close kin, (c) development of new modules from connective tissue, (d) synchronization of module budding, (e) programmed module death, (f) terminal differentiation of reproductive modules, and (g) architectural constraints. Effective mediation of module‐level conflicts, however, may in some cases contribute to cell‐level conflicts. Animal colonies typically have multipotent stem cells, and genetically variant stem cells can potentially monopolize gamete formation. Limiting colony fusion to close kin may not eliminate such conflict. Finally, in at least some taxa an association between photosymbiosis and coloniality is found. Allocation of photosynthate can lead to host‐symbiont conflicts that can be mediated by housing symbionts intracellularly and using chemiosmotic mechanisms to detect defectors. Colonial animals thus serve as a living laboratory of evolutionary conflict and its mediation.
Consanguineous marriage and its effect on reproductive behavior and uptake of prenatal screening
Authors: Sahin Eda , İnciser Paşalak Şeyma , Seven Memnun 
Published: January 2020

AbstractThe study aimed to determine the prevalence of consanguinity among pregnant women, its effect on reproductive behavior and the uptake of prenatal screening. The sample consisted of 842 pregnant women recruited to a prospective cohort study conducted in twenty‐three cities from different regions in Turkey between June 2017 and March 2018. Of the women, 17.7% (n = 149) were in consanguineous marriages. The consanguineous couples were younger at the time of their marriages than non‐consanguineous couples, and 49% of the consanguineous marriages were arranged. The educational levels of both spouses in consanguineous marriages were lower than those in non‐consanguineous marriages. There was a statistically significant difference in the prevalence of the pregnant women having a prenatal screening test between women in consanguineous marriages (53%) and those in non‐consanguineous marriages (78.2%). There were no statistically significant differences between the two groups in terms of having health problems during pregnancy, the number of pregnancies, abortions and/or stillbirths, the week of delivery and the birthweight of the baby. Healthcare providers play a key role in eliciting whether or not pregnant couples are consanguineous, providing a tailored risk assessment, education, and counseling about screening and diagnostic tests for early diagnosis and management of the fetus, explaining the testing process and possible outcomes, and helping couples make informed decisions regarding their reproductive options or pregnancy management.
Histogram Analysis Comparison of Monoexponential, Advanced Diffusion‐Weighted Imaging, and Dynamic Contrast‐Enhanced MRI for Differentiating Borderline From Malignant Epithelial Ovarian Tumors
Authors: He Mengge , Song Yang , Li Haiming , Lu Jing , Li Yongai , Duan Shaofeng , Qiang Jinwei 
Published: January 2020

BackgroundThe accurate preoperative differentiation between borderline and malignant epithelial ovarian tumors (BEOTs vs. MEOTs) is crucial for determining the proper surgical strategy and improving the patient's postoperative quality of life. Several diffusion and perfusion MRI technologies are valuable for the differentiation; however, which is the best remains unclear.PurposeTo compare the whole solid‐tumor volume histogram analysis of diffusion‐weighted imaging (DWI), diffusion kurtosis imaging (DKI), intravoxel incoherent motion (IVIM), and dynamic contrast‐enhanced MRI (DCE‐MRI) in the differentiation of BEOTs vs. MEOTs and to identify the correlations between the perfusion parameters from IVIM and DCE‐MRI.Study TypeRetrospective.PopulationTwenty patients with BEOTs and 42 patients with MEOTs.Field Strength/Sequence1.5T/DWI, DKI, and IVIM models fitting from 13 different b factors and 40 phases DCE‐MRI.AssessmentHistogram metrics were derived from the apparent diffusion coefficient (ADC), diffusion kurtosis (K), diffusion coefficient (Dk), pure diffusion coefficient (D), pseudodiffusion coefficient (D*), perfusion fraction (f), volume transfer constant (Ktrans), rate constant (kep), and extravascular extracellular volume fraction (ve).Statistical TestsThe Mann–Whitney U‐test and receiver operating characteristic curve were used to determine the best histogram metrics and parameters. Multivariate logistic regression analysis was used to determine the best combined model for each two from the four technologies. Spearman's rank correlation was used to analyze the correlations between the IVIM and DCE‐MRI parameters.ResultsADC, D, Dk, and D* were significantly higher in BEOTs than in MEOTs (P < 0.05). K, Ktrans, kep, and ve were significantly lower in BEOTs than in MEOTs (P < 0.05). The 10th percentile of Dk was the most reliable single metric, with an area under the curve (AUC) of 0.921. Dk combined with Ktrans yielded the highest AUC of 0.950. A weak inverse correlation was found between D and Ktrans (r = −0.320, P = 0.025) and between D and kep (r = −0.267, P = 0.037).Data ConclusionThe 10th percentile of Dk was the most valuable metric and Dk combined with Ktrans had the best performance for differentiating BEOTs from MEOTs. There was no evident link between perfusion‐related parameters derived from IVIM and DCE‐MRI.Level of Evidence: 4Technical Efficacy Stage: 2J. Magn. Reson. Imaging 2020;52:257–268.
Multiclass and multiresidue screening of veterinary drugs and pesticides in infant formula using Quadrupole‐Orbitrap MS with PRM scan mode
Authors: Zhang Lu‐Qi , Zhang Xiao‐Mei , Zhang Hong‐Wei , Wang Hui , Xu Hui , Wang Feng‐Mei , Lin Chao , Xiao Jing , Xu Wen‐Yuan 
Published: January 2020

AbstractA multiclass and multiresidue method for screening veterinary drugs and pesticides in infant formula was developed and validated using ultrahigh‐performance liquid chromatography coupled to Quadrupole‐Orbitrap high‐resolution mass spectrometry (UHPLC‐HRMS). A total of 49 veterinary drugs and pesticides investigated belong to 11 classes including antivirals, anticoccidials, macrolides, pyrethroids, insecticides, sulfonamides, beta‐agonists, sedatives, thyreostats, nonsteroidal anti‐inflammatory drugs, and other pharmacologically active substances. A generic sample preparation and highly selective acquisition mode of parallel reaction monitoring (PRM) were deliberately incorporated to perform efficient screening analysis. As a result, the screening target concentrations of the analytes varied from 1 to 500 μg/kg with ≤5% of false compliant rate as specified in Decision 2002/657/EC for screening analysis. The average recoveries ranged from 40.7 to 124.9% as well as the relative standard deviations from 4.2 to 26.6%, respectively. The matrix effects and interferences were effectively controlled by integrated application of dispersive solid phase extraction, PRM scan mode, and matrix‐matched standard calibration. The proposed method will be helpful to provide applicable strategy for screening residues in infant formula with surveillance purpose.
The ability of two chlorine dioxide chemistries to inactivate human papillomavirus‐contaminated endocavitary ultrasound probes and nasendoscopes
Authors: Meyers Craig , Milici Janice , Robison Richard 
Published: January 2020

AbstractSexual transmission is the most common pathway for the spread of Human papillomavirus (HPV). However, the potential for iatrogenic HPV infections is also real. Even though cleared by the Food and Drug Administration and recommended by the World Federation for Ultrasound in Medicine and Biology, several disinfectants including glutaraldehyde and o‐phthalaldehyde have shown a lack of efficacy for inactivating HPV. Other methods such as ultraviolet C and concentrated hydrogen peroxide have been shown highly effective at inactivating infectious HPV. In this study, two chlorine dioxide systems are also shown to be highly efficacious at inactivating HPV. An important difference in these present studies is that as opposed to testing in suspension or using a carrier, we dried the infectious virus directly onto endocavitary ultrasound probes and nasendoscopes, therefore, validating a more realistic system to demonstrate disinfectant efficacy.
Precipitation regionalization, anomalies and drought occurrence in the Yucatan Peninsula, Mexico
Authors: De la Barreda Betsabé , Metcalfe Sarah E. , Boyd Doreen S. 
Published: January 2020

AbstractClimate change projections have identified the Yucatan Peninsula as being vulnerable to increasing drought. Understanding spatial and temporal precipitation variability and drought occurrence are therefore important. Drought monitoring in Mexico has been carried out only relatively recently and often without considering the long‐term variability in both droughts and precipitation. This research explores the spatio‐temporal variability of precipitation and occurrence of droughts at a much finer spatial resolution and over a longer temporal period than previous studies. Using statistical (cluster analysis and standardized precipitation index) and geostatistical (kriging) techniques, maps of precipitation and droughts are generated for the period 1980–2011. These show that whilst many previous studies have regarded the Yucatan Peninsula as a homogenous region with respect to precipitation, there are actually four distinctive clusters of precipitation amount, showing climatic variability across the Peninsula. The analyses also show that droughts in the Peninsula are regionalised. Twelve‐month Standardized Precipitation Indices (SPI), calculated for individual stations and for precipitation surfaces, reveal distinct patterns of spatial and temporal variability. SPI surfaces indicate the occurrence of major droughts in 1981, 1986–1987, 1994, 1996, 2003, 2004 and 2009, but these rarely affect the whole Yucatan Peninsula uniformly. Wetter years, such as 1983, 1984, 1988, 1992, 1995, 2002 and 2005 sometimes reflect the impact of individual extreme events, such as hurricaneIsidorein 2002. Our results show that drought can be regionalised, thus enhancing the quality of information about droughts in the area and providing evidence and support for future drought mitigation and environmental protection. These methods could usefully be applied elsewhere.
Exploring new genetic variants within COL5A1 intron 4‐exon 5 region and TGF‐β family with risk of anterior cruciate ligament ruptures
Authors: Laguette Mary‐Jessica N. , Barrow Kelly , Firfirey Firzana , Dlamini Senanile , Saunders Colleen J. , Dandara Collet , Gamieldien Junaid , Collins Malcolm , September Alison V. 
Published: January 2020

AbstractVariants within genes encoding structural and regulatory elements of ligaments have been associated with musculoskeletal soft tissue injury risk. The role of intron 4‐exon 5 variants within the α1 chain of type V collagen (COL5A1) gene and genes of the transforming growth factor‐β (TGF‐β) family, TGFBR3 and TGFBI, was investigated on the risk of anterior cruciate ligament (ACL) ruptures. A case‐control genetic association study was performed on 210 control (CON) and 249 participants with surgically diagnosed ruptures (ACL), of which 147 reported a noncontact mechanism of injury (NON). Whole‐exome sequencing data were used to prioritize variants of potential functional relevance. Genotyping for COL5A1 (rs3922912 G>A, rs4841926 C>T, and rs3124299 C>T), TGFBR3 (rs1805113 G>A and rs1805117 T>C), and TGFBI (rs1442 G>C) was performed using Taqman SNP genotyping assays. Significant overrepresentation of the G allele of TGFBR3 rs1805113 was observed in CON vs ACL (P = .014) and NON groups (P = .021). Similar results were obtained in a female with the G allele (CON vs ACL: P = .029; CON vs NON: P = .016). The TGFBI rs1442 CC genotype was overrepresented in the female ACL vs CON (P = .013). Associations of inferred allele combinations were observed in line with the above results. COL5A1 intron 4‐exon 5 genomic interval was not associated with the risk of ACL ruptures. Instead, this novel study is the first to use this approach to identify variants within the TGF‐β signaling pathway to be implicated in the risk of ACL ruptures. A genetic susceptibility interval was identified to be explored in the context of extracellular matrix remodeling.
Cocaine, polysubstance abuse, and oral health outcomes, NHANES 2009 to 2014
Authors: Bahdila Dania , Aldosari Muath , Abdullah Abeer , Nelson Jevae L. , Hegazi Fahad , Badamia Riddhi , Alhazmi Hesham , Chandel Tejasvita , Odani Satomi , Vardavas Constantine I. , Agaku Israel T. 
Published: January 2020

AbstractBackgroundCocaine is the second most abused illicit drug in the United States. To date, no study has examined the association between cocaine use and oral health with a nationally representative sample. Our study examined the association between cocaine use—singly and with other substances—and oral health outcomes, including periodontitis and untreated caries, among US adults.MethodsData for 11,753 individuals, aged ≥30 years, who completed a periodontal examination, in the 2009 to 2014 National Health and Nutrition Examination Survey (NHANES) were analyzed. Descriptive analyses and multivariable binary logistic regression analyses were conducted on weighted data.ResultsOverall, 17% (20.5 million) of US adults aged ≥30 years had ever used cocaine, with higher likelihood seen among males, non‐Hispanic whites, and those living in poverty. Current cocaine use prevalence was 2.6% (3.2 million). By number of co‐used substances, the odds of having any periodontitis were higher among cocaine users who consumed ≥3 other substances (adjusted OR = 2.47; 95% CI = 1.15 to 5.30) when compared with solely cocaine users. By type of substance co‐used, odds of having untreated caries were greater among those reporting cigarettes (adjusted OR = 1.94; 95% CI = 1.21 to 3.11) or methamphetamine (adjusted OR = 5.40; 95% CI = 1.92 to 15.14) usage. Odds of any periodontitis were higher among those reported ancillary cigarette use (adjusted OR = 2.84; 95% CI = 1.60 to 5.04) compared with cocaine‐only users.ConclusionsIn addition to a positive association between periodontal disease, dental caries, and cocaine use, select co‐usage elevated the risk of oral disease. Patients should be screened for and counseled regarding substance abuse to facilitate a successful quit.
Analysing domestic tourism flows at the provincial level in Spain by using spatial gravity models
Authors: Alvarez‐Diaz Marcos , D'Hombres Beatrice , Ghisetti Claudia , Pontarollo Nicola 
Published: January 2020

AbstractDomestic tourism represents a large share of the total tourism volume in Spain, but it is still an under‐researched topic. This study focuses on the determinants of domestic flows in Spain at provincial level. The prior assumption is that domestic tourism demand may be affected by specific local conditions that previous studies, mostly based on more aggregate data, would hardly capture. A gravity model and various spatial econometric models are estimated assuming alternative spatial weighting matrices. Results suggest that income and relative prices affect tourism demand in Spanish provinces as well as weather, natural amenities, infrastructures, and recreational activities.
Validation and multidimensional analysis of the japanese penn acoustic neuroma quality‐of‐life scale
Authors: Nishiyama Takanori , Oishi Naoki , Kojima Takashi , Kasuya Kento , Noguchi Masaru , Ishikawa Toru , Hosoya Makoto , Ogawa Kaoru 
Published: January 2020

ObjectivesIn the management of vestibular schwannoma (VS), patient‐perceived outcomes should be given as much attention as physician‐reported objective outcomes. Concomitant symptoms can be annoying for sufferers, lowering quality of life (QoL). However, it is difficult to determine the degree to which these symptoms lower QoL using only objective measures. The Penn Acoustic Neuroma Quality of Life Scale (PANQOL) is a validated disease‐specific questionnaire commonly used to assess QoL in VS patients. It was developed and published in English. In this study, we translated the PANQOL questionnaire into Japanese and validated its reliability and utility. We also evaluated patient factors that could influence PANQOL scores.Study DesignCross‐sectional study.MethodsSeventy‐two VS patients monitored conservatively were included in this study. They were assessed using the Japanese versions of PANQOL (PANQOL‐J) and questionnaires about specific symptoms related to VS. The PANQOL questionnaire was translated into Japanese according to the accepted standards. The reliability and utility of the PANQOL‐J questionnaire, as well as the relationship with VS‐specific symptoms, were statistically analyzed.ResultsThe mean total score was 78.7. Almost all of its domains had good internal consistency. Most PANQOL‐J domains were related to those of the Short Form‐36, with the exception of facial dysfunction domain. Scores of all PANQOL‐J domains were comparable to scores of other questionnaires related to the VS‐specific symptoms. Our analyses indicated tinnitus or facial palsy might affect the PANQOL‐J total score.ConclusionsWe confirmed the validity of the Japanese version of PANQOL questionnaire and its reliability and utility in the management of VS symptoms concerning facial function.Level of Evidence4 Laryngoscope, 2020