bluuebunny/crossref_metadata_2025_split huggingface dataset:
Willingness, perceived barriers and motivators in adopting mobile applications for health-related interventions among older adults: a scoping review protocol
Authors: Ahmad Nurul Asilah , Mat Ludin Arimi Fitri , Shahar Suzana , Mohd Noah Shahrul Azman , Mohd Tohit Noorlaili 
Published: March 2020

IntroductionThe world’s older population continues to grow at an unprecedented rate. An ageing population poses a great challenge to our healthcare system that requires new tool to tackle the complexity of health services as well as the increasing expenses. Mobile health applications (mHealth app) is seen to have the potential to address these challenges, alleviating burdens on the healthcare system and enhance the quality of life for older adults. Despite the numerous benefits of mHealth apps, relatively little is known about whether older adults perceive that these apps confer such benefits. Their perspectives towards the use of mobile applications for health-related purposes have also been little studied. Therefore, in this paper, we outline our scoping review protocol to systematically review literature specific to older adults’ willingness, perceived barriers and motivators towards the use of mobile applications to monitor and manage their health.Methods and analysisArksey and O’Malley’s scoping review methodology framework will guide the conduct of this scoping review. The search strategy will involve electronic databases including PubMed, Excerpta Medica Database, Cumulative Index of Nursing and Allied Health Literature, Cochrane Library, Google Scholar and ScienceDirect, in addition to grey literature sources and hand-searching of reference lists. Two reviewers will independently screen all abstracts and full-text studies for inclusion. Data will be charted and sorted through an iterative process by the research team. The extracted data will undergo a descriptive analysis and simple quantitative analysis will be conducted using descriptive statistics. Engagement with relevant stakeholders will be carried out to gain more insights into our data from different perspectives.Ethics and disseminationSince the data used are from publicly available sources, this study does not require ethical approval. Results will be disseminated through academic journals, conferences and seminars. We anticipate that our findings will aid technology developers and health professionals working in the area of ageing and rehabilitation.
Access and use of oxytocin for postpartum haemorrhage prevention: a pre-post study targeting the poorest in six Mesoamerican countries
Authors: Kamath Aruna M , Schaefer Alexandra M , Palmisano Erin B , Johanns Casey K , Gonzalez Marmol Alvaro , Dinarte Mendoza Mauricio , Schwarzbauer Karla , Zúñiga-Brenes Paola , Ríos-Zertuche Diego , Iriarte Emma , Mokdad Ali H , Hernandez Prado Bernardo 
Published: March 2020

ObjectivesHaemorrhage remains the leading cause of maternal mortality in Central America. The Salud Mesoamérica Initiative aims to reduce such mortality via performance indicators. Our objective was to assess the availability and administration of oxytocin, before and after applying Salud Mesoamérica Initiative interventions in the poorest health facilities across Central America.DesignPre-post study.Setting166 basic-level and comprehensive-level health facilities in Belize, Guatemala, Honduras, Mexico, Nicaragua and Panama.ParticipantsA random sample of medical records for uncomplicated full-term deliveries (n=2470) per International Classification of Diseases coding at baseline (July 2011 to August 2013) and at first-phase follow-up (January 2014 to October 2014).InterventionsA year of intervention implementation prior to first-phase follow-up data collection focused on improving access to oxytocin by strengthening supply chains, procurement, storage practices and pharmacy inventory monitoring, using a results-based financing model.Primary and secondary outcome measuresOxytocin availability (primary outcome) and administration (secondary outcome) for postpartum haemorrhage prevention.ResultsAvailability of oxytocin increased from 82.9% to 97.6%. Oxytocin administration increased from 83.6% to 88.4%. Significant improvements were seen for availability of oxytocin (adjusted OR (aOR)=8.41, 95% CI 1.50 to 47.30). Administration of oxytocin was found to be significantly higher in Honduras (aOR=2.96; 95% CI 1.00 to 8.76) in reference to Guatemala at follow-up.ConclusionAfter interventions to increase health facility supplies, the study showed a significant improvement in availability but not administration of oxytocin in poor communities within Mesoamerica. Efforts are needed to improve the use of oxytocin.
Phase II double-blind randomised controlled trial of exogenous administration of melatonin in chronic pain (DREAM—CP): a study protocol
Authors: Adam Rosalind , Kanakarajan Saravanakumar , Onyeakazi Uzunma , Columb Malachy , Galley Helen 
Published: March 2020

IntroductionChronic pain is prevalent, and approximately half of patients with chronic pain experience sleep disturbance. Exogenous melatonin is licensed to treat primary insomnia and there is some evidence for analgesic effects of melatonin.The aim of this study is to investigate the effects of oral melatonin (as Circadin) 2 mg at night in adults with severe non-malignant pain of at least 3 months’ duration.Methods and analysisWe will conduct a randomised double-blind placebo-controlled cross-over study. The primary outcome is sleep disturbance. Secondary outcomes are pain intensity, actigraphy, fatigue, reaction time testing, serum melatonin and endogenous opioid peptide levels along with patient views about study participation.We aim to recruit 60 patients with severe chronic pain (average pain intensity ≥7 on the Brief Pain Inventory (BPI)) from a tertiary referral pain clinic in Northeast Scotland. Participants will be randomised to receive melatonin (as modified release Circadin) 2 mg daily for 6 weeks or placebo, followed by a 4-week washout period, then 6 weeks treatment with the treatment they did not receive. Participants will complete the Verran Snyder-Halpern Sleep Scale, Pittsburgh Sleep Quality Index, Pain and Sleep Questionnaire 3-item index, BPI and psychomotor vigilance reaction time testing at 6 points over 20 weeks. Actigraphy watches will be used to provide objective measures of sleep duration and latency and other sleep measures and will prompt patients to report contemporaneous pain and fatigue scores daily.Cross-over analyses will include tests for effects of treatment, period, treatment–period interaction (carryover effect) and sequence. Within-patient effects and longitudinal data will be analysed using mixed linear models, accounting for potential confounders.Ethics and disseminationApproved by Office for Research Ethics Committees Northern Ireland, reference 19/NI/0007. Results will be published in peer-reviewed journals and will be presented at national and international conferences.Trial registration numberISRCTN12861060
Pain Squad+ smartphone app to support real-time pain treatment for adolescents with cancer: protocol for a randomised controlled trial
Authors: Jibb Lindsay , Nathan Paul C , Breakey Vicky , Fernandez Conrad , Johnston Donna , Lewis Victor , McKillop Sarah , Patel Serina , Sabapathy Christine , Strahlendorf Caron , Victor J. Charles , Moretti Myla E , Nguyen Cynthia , Hundert Amos , Cassiani Celia , El-Khechen Richandi Graziella , Insull Hayley , Hamilton Rachel , Fang Geoffrey , Kuczynski Susan , Stinson Jennifer 
Published: March 2020

IntroductionPain negatively affects the health-related quality of life (HRQL) of adolescents with cancer. The Pain Squad+ smartphone-based application (app), has been developed to provide adolescents with real-time pain self-management support. The app uses a validated pain assessment and personalised pain treatment advice with centralised decision support via a registered nurse to enable real-time pain treatment in all settings. The algorithm informing pain treatment advice is evidence-based and expert-vetted. This trial will longitudinally evaluate the impact of Pain Squad+, with or without the addition of nurse support, on adolescent health and cost outcomes.Methods and analysisThis will be a pragmatic, multicentre, waitlist controlled, 3-arm parallel-group superiority randomised trial with 1:1:1 allocation enrolling 74 adolescents with cancer per arm from nine cancer centres. Participants will be 12 to 18 years, English-speaking and with ≥3/10 pain. Exclusion criteria are significant comorbidities, end-of-life status or enrolment in a concurrent pain study. The primary aim is to determine the effect of Pain Squad+, with and without nurse support, on pain intensity in adolescents with cancer, when compared with a waitlist control group. The secondary aims are to determine the immediate and sustained effect over time of using Pain Squad+, with and without nurse support, as per prospective outcome measurements of pain interference, HRQL, pain self-efficacy and cost. Linear mixed models with baseline scores as a covariate will be used. Qualitative interviews with adolescents from all trial arms will be conducted and analysed.Ethics and disseminationThis trial is approved by the Hospital for Sick Children Research Ethics Board. Results will provide data to guide adolescents with cancer and healthcare teams in treating pain. Dissemination will occur through partnerships with stakeholder groups, scientific meetings, publications, mass media releases and consumer detailing.Trial registration numberNCT03632343(ClinicalTrials.gov).
Outcomes of pars plana vitrectomy with subretinal tissue plasminogen activator injection and pneumatic displacement of fovea-involving submacular haemorrhage
Authors: Wilkins Carl S , Mehta Neesurg , Wu Chris Y , Barash Alexander , Deobhakta Avnish A , Rosen Richard B 
Published: March 2020

ObjectiveFovea-involving subretinal haemorrhage is challenging to manage with uncertain visual outcomes. We reviewed outcomes of patients with fovea-involving macular haemorrhage treated with pars plana vitrectomy (PPV) and subretinal tissue plasminogen activator (tPA) with pneumatic displacement.Methods and AnalysisThis is a retrospective interventional case series. All patients with submacular haemorrhage who underwent PPV with subretinal tPA injection were included. Reasons for exclusion encompassed patients who underwent intravitreal tPA injection in the office without surgery, insufficient follow-up or documentation. Primary outcomes of interest were postoperative visual acuity (VA) at month 1 and 3. Secondary outcomes were median VA at month 3 by location of haemorrhage and underlying diagnosis.ResultsThirty-seven total patients were included. The mean age was 68.2 years, with 54.1% (20/37) females. The most common aetiology was exudative macular degeneration (43.2%), followed by undifferentiated choroidal neovascularisation (CNV) (18.9%), polypoidal choroidal vasculopathy (18.9%), traumatic CNV (10.8%), macroaneurysm (5.4%) and proliferative diabetic retinopathy (2.7%). Median preoperative VA was 20/2000, postoperative month 1 was 20/347 (p<0.01), improving to 20/152 (p<0.01) at month 3. Proportion of patients gaining vision 3+ lines in vision was 15/36 (42%). Mean preoperative central subfield thickness on optical coherence tomography was 512.2 µm for sub-retinal pigment epithelium haemorrhage and 648.2 µm for subretinal haemorrhage (p=0.48). Difference in VA by diagnosis was not significant (p=0.60).ConclusionsPPV with subretinal tPA injection and pneumatic displacement of submacular haemorrhage offers modest visual recovery for a diverse group of patients. Location of haemorrhage or specific diagnosis may not predict outcome.
Austrolimnius cleidecostae, a new species of riffle beetle (Coleoptera: Elmidae) from Brazil with habitat notes and updated key of the Brazilian species of the genus
Authors: Polizei Thiago Tadeu Silva , Costa Lucas De Souza Machado , Bispo Pitágoras Da Conceição 
Published: March 2020

Austrolimnius cleidecostae sp. nov. is one of the smallest species of Elmidae from the Neotropical region. The new species is described and illustrated based on male and female specimens. This species represents the first record in Elmidae of mandibles with an articulated, sclerotized process on inner subapical edge. The specimens were collected from streams in the Atlantic rainforest of São Paulo and Santa Catarina, and habitat notes are given. An updated key for the Austrolimnius Carter & Zeck, 1929 of Brazil is provided. Austrolimnis browni Hinton, 1971 and A. musgravei Hinton, 1939 are recorded for the first time from Brazil.
A new species of Neapion (Neotropion) Alonso-Zarazaga from Paraguay (Brentidae: Apioninae)
Authors: De Sousa Wesley Oliveira 
Published: March 2020

A new species of the genus Neapion Alonso-Zarazaga, 1990 subgenus Neotropion Alonso-Zarazaga, 1990 (Brentidae: Apioninae) is described and illustrated. Neapion (Neotropion) cleidecostae sp. nov. (Type locality: Paraguay, Misiones) is the second Apioninae species from South America with dense, thin vestiture and raised areas on the elytra. In addition to these characters, vestiture color pattern and male genitalic characters such as penis shape, length of the tuning fork-shaped sclerite in the internal sac (the largest found in Apioninae), and shape of the tegminal plate are diagnostic of this new species.
A revision of Peltariosilis Wittmer (Coleoptera: Cantharidae), a surprisingly diverse Amazonian radiation
Authors: Biffi Gabriel , Geiser Michael 
Published: March 2020

Peltariosilis Wittmer, 1952 is a South American Silinae genus characterised by the highly modified male pronotum and scutellum with a remarkable lamellar projection. Six species were previously recognised. The study of numerous specimens from previously unsampled localities and the revision of previously studied material shows that Peltariosilis is far more diverse than previously recognised. 15 species are here recognised as valid, nine of which are described as new: P. brancuccii, P. brunneoapicalis, P. cleidecostae, P. diversicollis, P. flavicornis, P. gracilicornis, P. major, P. orientalis and P. parviscutellaris spp. nov. A comparative study and new morphological terminologies are introduced for pronotum, scutellum and male genitalia. All Peltariosilis species are described and illustrated, including the first illustration of a female pronotum, and an identification key is provided. A map is given, including records of all known Peltariosilis, showing a distribution confined to the Amazonian subregion (Suriname, French Guiana, N Brazil, E Peru and NE Bolivia). The identity of the type species P. scutulata (Wittmer, 1952), hitherto considered as broadly distributed and highly variable, is addressed through study of their type series and additional specimens from widespread localities.
Laccodytes costae sp. nov., and new records for the genus from Brazil (Coleoptera: Dytiscidae)
Authors: Braga Rafael Benzi , Ferreira Junior Nelson 
Published: March 2020

Laccodytes costae sp. nov., from Brazil, is described and illustrated; the new species is the third known member of the Laccodytes apalodes species-group. New records for Brazil: Laccodytes americanus Peschet, 1919, new for the country and Laccodytes rondonia Toledo, Spangler & Balke, 2010, new for the state of Pará. A modified version of the key from Toledo, Spangler & Balke (2010) is provided with new couplets to allow the identification of the new species as well as L. cobreinae Toledo, Megna & Alarie, 2011.
Two new species of Passalus Fabricius (Coleoptera: Passalidae) from the western Brazilian Amazon with comments on the taxonomic limits of the subgenera
Authors: Bevilaqua Marcus , Fonseca Claudio Ruy Vasconcelos da 
Published: March 2020

Passalus Fabricius, 1792 is the largest genus of Passalidae and presents great diversity in South America, mainly in the Amazon region. Currently this complex and heterogeneous genus is subdivided into three subgenera: P. (Pertinax) Kaup, 1869, P. (Mitrorhinus) Kaup, 1871, and P. (Passalus). Herein, two new species of Passalus from the western region of the Brazilian Amazon, a diverse but poorly studied area, are described and illustrated. The new species Passalus (Pertinax) deuterocerus sp. nov. and Passalus (Passalus) cleidecostae sp. nov. are compared with similar species occurring in nearby regions. Also, the diagnostic characters used to define the subgenera and sections of Passalus are summarized.
A new species of Chlorota Burmeister (Melolonthidae: Rutelinae: Rutelini) from Cerrado and Amazon biomes transition
Authors: Medeiros Rone Andrews Freitas , Grossi Paschoal Coelho 
Published: March 2020

Chlorota cleidecostae sp. nov. is described based on a unique female collected at Maranhão State, Carolina municipality, in the “Meio Norte” region, a biotope comprising Cerrado, Caatinga and Amazon biomes. The new species is distinguished from all other Chlorota species by having the striped elytral pattern with red costae, and surface of pronotum dull, dark, metallic, and smooth. An updated map and a key for species and subspecies that occur in Brazil are also presented.
Morphology of the adult and immatures of a striking new species of leaf-mining Brachys Dejean from Brazil (Buprestidae, Agrilinae)
Authors: Migliore Letizia Janaina , Casari Sonia A. , Paiola Gabriel 
Published: March 2020

Adult and immature stages of a new species, Brachys cleidecostae sp. nov., are described and illustrated. This species represents the first leaf-mining buprestid with two broad, prominent horn-like apophyses on vertex, resembling broad horns. The material was collected within unusual shaped leaf mines in Alibertia sessilis (Vell.) K. Schum (Rubiaceae), a native species from Brazilian Savanna (Cerrado). This is the first record of Brachys associated with a host plant of family Rubiaceae.
<p><strong>The endemic and range restricted vascular plants of Croatia: diversity, distribution patterns and their conservation status</strong></p>
Authors: NIKOLIĆ TONI , FOIS MAURO , MILAŠINOVIĆ BORIS 
Published: March 2020

The Balkan Peninsula is recognized as an important centre of native and endemic plant species diversity as well as an important wildlife refuge area. However, although Croatia hosts more than half of plant species found on the Balkan Peninsula, the endemic taxa have never been evaluated or used to define conservation priorities. We analyzed the qualitative composition of the endemic and range restricted species, their spatial distribution, centres of endemism, and conservation status (non-IUCN). We generated an updated and annotated checklist of 349 endemic or range-restricted plant taxa (6.9% of the entire native flora), subdivided in 231 species, 103 subspecies and 15 hybrids and belonging to 149 genera and 43 families. Among the 231 species, 69 are considered endemic to Croatia and confined to a small area (< 4,500 km2), while 162 are considered range restricted species, which have larger ranges and/or are shared with neighbouring countries. The genera Centaurea and Hieracium have the highest number of endemic and range restricted taxa. Spatial analyses indicated two notable centres of species richness—the mountainous Dinaric Alps and the SE Adriatic coast, including the islands. Regions with a high richness of range-restricted taxa did not coincide with areas of high richness of endemic species. Taxa exhibited modest bimodality with respect to altitudinal distribution. In addition, the greatest diversity of taxa is concentrated in northwest of Croatia and could be related to differences in mean annual air temperatures and the duration of insolation. As regards their conservation status, 13 of the 349 taxa are endangered, and 62 are near threatened or vulnerable. Despite relatively strong legal protection of endemic and range restricted species, 37 taxa remain unprotected. Changes in conservation practice are therefore proposed.
Dry Eye and Dry Nose Caused by the Effect of Allergic Rhinitis on Tear and Nasal Secretion Osmolarity
Authors: Yenigun Alper , Elbay Ahmet , Ozdem Abdullah , Bayraktar Havvanur , Ozer Omer Faruk , Dogan Remzi , Ozturan Orhan 
Published: March 2020

Objective: Allergic rhinitis is a type 1 hypersensitivity reaction of immunoglobulin E in the rhino-ocular mucosa. This study was planned to demonstrate in patients with allergic rhinitis to evaluate changes in tear, nasal secretions, and blood osmolarity compared to healthy individuals. Method: Forty allergic rhinitis patients, 25 patients with acute upper respiratory tract infections, and 26 healthy participants were included in the study. Positive patients with allergic symptoms and skin prick test results were included in the allergic rhinitis group. Tear, nasal secretion, and blood osmolarity values were examined for the 3 groups. Result: In patients with allergic rhinitis, tear and nasal secretion osmolarity values were significantly higher in patients with acute upper respiratory tract infections and those of the healthy participants ( P = .001, P = .038). In blood osmolarity measurements, there was no statistical difference between the groups ( P = .489). In patients with allergic rhinitis, Schirmer test results were significantly shorter than patients who had acute upper respiratory tract infection and those of the healthy participants ( P = .001, P = .001). Patients with allergic rhinitis and acute upper respiratory tract infections had significantly shorter Schirmer test results than in healthy participants ( P = .001, P = .001). Conclusion: Tear osmolarity was increased in allergic rhinitis patients, and this was thought to lead to dry eye findings. In the presence of allergic rhinitis, nasal secretions were found more hyperosmolar than tears. Nasal secretion osmolarity was higher in allergic rhinitis patients than in patients with acute upper respiratory tract infections and control group.
Effect of a Standardized Electronic Medical Record Order Set on Opioid Prescribing after Tonsillectomy
Authors: Horton Joshua D. , Corrigan Corinne , Patel Terral , Schaffer Caroline , Cina Robert A. , White David R. 
Published: March 2020

ObjectiveApproximately 5% of children develop new persistent opioid use after tonsillectomy. Critical review of our prescribing practices revealed inconsistent and excessive opioid prescribing after this procedure in children. We sought to improve our practice by using a standardized electronic medical record (EMR)–based order set.MethodsRetrospective chart review of outpatient tonsillectomy performed before and after institution of an EMR intervention with comparison of opioid and nonopioid analgesic (NOA) prescription characteristics as well as outcomes including hemorrhage and readmission.ResultsAnalysis of 276 preorder set and 128 post–order set tonsillectomies revealed a significant increase in NOA utilization following initiation of the order set and a significant reduction in doses of opioid prescribed. Due to a change to a stronger opioid in the order set, morphine dose equivalents (MDEs) prescribed were not decreased in the post–order set cohort. Variability between prescriptions and providers was significantly decreased in the post–order set group in terms of doses and MDEs, and dangerously high outlier prescriptions were eliminated. No differences in pain control, postoperative hemorrhage, presentation to the emergency department, or readmission were identified.DiscussionAn EMR‐based intervention improved the quality and safety of posttonsillectomy opioid prescribing at our institution. Moving forward, this order set provides a platform with which to titrate opioid prescriptions and NOA to optimal pain control and safety levels.Implications for PracticeA standardized EMR‐based order set can improve the quality of opioid prescribing after tonsillectomy.