bluuebunny/crossref_metadata_2025_split huggingface dataset:
The oncogenic role of MUC12 in RCC progression depends on c‐Jun/TGF‐β signalling
Authors: Gao Sheng‐Lin , Yin Rui , Zhang Li‐Feng , Wang Si‐Min , Chen Jia‐Sheng , Wu Xing‐Yu , Yue Chuang , Zuo Li , Tang Min 
Published: June 2020

AbstractRenal cell carcinoma (RCC) is a common kidney cancer worldwide. Even though current treatments show promising therapeutic effectiveness, metastatic RCC still has limited therapeutic options so that novel treatments were urgently needed. Here, we identified that MUC12 was overexpressed in RCC patients and served as poor prognostic factor for RCC progression. Overexpression of MUC12 increased RCC cell growth and cell invasion while deficiency of MUC12 exerted opposite effects on RCC cells. Mechanistic dissection demonstrated that MUC12‐mediated RCC cell growth and cell invasion were dependent of TGF‐β1 signalling because they could be blocked in the presence of TGF‐β1 inhibitor. Moreover, the regulation of TGF‐β1 by MUC12 relied on the transactivation of c‐Jun. MUC12 promoted the recruitment of c‐Jun on the promoter of TGF‐β1, leading to its transcription. Importantly, knockdown of c‐Jun also attenuated MUC12‐mediated TGF‐β1 induction and RCC cell invasion. In summary, our study defines the role of MUC12 in RCC progression and provides rational to develop novel targeted therapy to battle against RCC.
FDPS promotes glioma growth and macrophage recruitment by regulating CCL20 via Wnt/β‐catenin signalling pathway
Authors: Chen Zhuo , Chen Guangyong , Zhao Hang 
Published: June 2020

AbstractGlioma is one of the most lethal tumours and common malignant in the central nervous system (CNS), which exhibits diffuse invasion and aggressive growth. Several studies have reported the association of FDPS to tumour development and progression. However, the role of FDPS in progression of glioma and macrophage recruitment is not well‐elucidated. In the current study, a remarkable enhancement in FDPS level was observed in glioma tissues and associated with poor prognosis, contributed to tumour growth. FDPS was correlated with macrophage infiltration in glioma and pharmacological deletion of macrophages largely abrogated the oncogenic functions of FDPS in glioma. Mechanistically, FDPS activated Wnt/β‐catenin signalling pathway and ultimately facilitates macrophage infiltration by inducing CCL20 expression. In conclusion, overexpressed FDPS exhibits an immunomodulatory role in glioma. Therefore, targeting FDPS may be an effective therapeutic strategy for glioma.
LncRNA SNHG3 promotes bladder cancer proliferation and metastasis through miR‐515‐5p/GINS2 axis
Authors: Dai Guangcheng , Huang Chenchen , Yang Jinhui , Jin Lu , Fu Kai , Yuan Feng , Zhu Jin , Xue Boxin 
Published: June 2020

AbstractGrowing evidence suggests that long non‐coding RNAs (lncRNAs) are associated with carcinogenesis. LncRNA small nucleolar RNA host gene 3 (SNHG3) is up‐regulated in various cancers and positively associated with poor prognosis of these cancers. However, the precise role of lncRNA SNHG3 in bladder cancer (Bca) remains unclear. In our research, we first reported that lncRNA SNHG3 was up‐regulated in bladder cancer tissues and positively related to poor clinical prognosis. Moreover, knockdown of lncRNA SNHG3 significantly suppressed the proliferation, migration, invasion and EMT process of Bca cells in vitro and vivo. Mechanistically, we revealed that suppression of SNHG3 evidently enhanced miR‐515‐5p expression and decreased GINS2 expression at posttranscriptional levels. Moreover, SNHG3 positively regulated GINS2 expression by sponging miR‐515‐5p under a competing endogenous RNA (ceRNA) mechanism. To sum up, our study suggested lncRNA SNHG3 acted as a microRNA sponge and an oncogenic role in the progression of bladder cancer.
Randomized trial of an intensified, multifactorial intervention in patients with advanced‐stage diabetic kidney disease: Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT‐Japan)
Authors: Shikata Kenichi , Haneda Masakazu , Ninomiya Toshiharu , Koya Daisuke , Suzuki Yoshiki , Suzuki Daisuke , Ishida Hitoshi , Akai Hiroaki , Tomino Yasuhiko , Uzu Takashi , Nishimura Motonobu , Maeda Shiro , Ogawa Daisuke , Miyamoto Satoshi , Makino Hirofumi ,   the Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT‐Japan) collaborative group
Published: June 2020

AbstractAims/IntroductionWe evaluated the efficacy of multifactorial intensive treatment (IT) on renal outcomes in patients with type 2 diabetes and advanced‐stage diabetic kidney disease (DKD).Materials and MethodsThe Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT‐Japan) is a multicenter, open‐label, randomized controlled trial with a 5‐year follow‐up period. We randomly assigned 164 patients with advanced‐stage diabetic kidney disease (urinary albumin‐to‐creatinine ratio ≥300 mg/g creatinine, serum creatinine level 1.2–2.5 mg/dL in men and 1.0–2.5 mg/dL in women) to receive either IT or conventional treatment. The primary composite outcome was end‐stage kidney failure, doubling of serum creatinine or death from any cause, which was assessed in the intention‐to‐treat population.ResultsThe IT tended to reduce the risk of primary end‐points as compared with conventional treatment, but the difference between treatment groups did not reach the statistically significant level (hazard ratio 0.69, 95% confidence interval 0.43–1.11; P = 0.13). Meanwhile, the decrease in serum low‐density lipoprotein cholesterol level and the use of statin were significantly associated with the decrease in primary outcome (hazard ratio 1.14; 95% confidence interval 1.05–1.23, P < 0.001 and hazard ratio 0.53, 95% confidence interval 0.28–0.998, P < 0.05, respectively). The incidence of adverse events was not different between treatment groups.ConclusionsThe risk of kidney events tended to decrease by IT, although it was not statistically significant. Lipid control using statin was associated with a lower risk of adverse kidney events. Further follow‐up study might show the effect of IT in patients with advanced diabetic kidney disease.
Resources and culture in organizations
Authors: Prasad Suraj , Tomaino Marcus 
Published: June 2020

AbstractWe look at how an organization's level of resources interacts with its culture—that is, its shared beliefs and preferences. We consider an organization where workers exert effort to develop projects. These projects (a) have externalities for other members, (b) compete for funds when resources are scarce, and (c) can be implemented in various ways, which members have beliefs and preferences over. When resources are plenty, so that all feasible projects are funded, workers' efforts are independent of each other and a coherent culture is optimal. By contrast, when resources are scarce, competition across workers with diverging beliefs or preferences (competing cultures) can be optimal.
Conserving and Extracting Nature: Environmental Politics and Livelihoods in the New “Middle Grounds” of Amazonia
Authors: High Casey , Oakley R. Elliott 
Published: June 2020

ResumenTanto como los pueblos de la Amazonía son conocidos en antropología por haber desafiado ideas modernistas de “la naturaleza,” industrias extractivas y varios proyectos de desarrollo los colocan al frente de conflictos acerca del medio ambiente. En 1995, Conklin y Graham identificaron que estas interfazes son cada vez mas translocales, provocando a describir un emergente “middle ground” que ubica los pueblos indígenas de la Amazonía y los ambientalistas occidentales como aliados naturales. Reconociendo veinticinco años de la Journal of Latin American and Caribbean Anthropology y del artículo seminal de Conklin y Graham, este “jubilee special issue” reconsidera el concepto “middle ground” en el contexto de nuevos y emergentes relaciones en la Amazonía contemporánea. Al conceptualizer los “new middle grounds” de conservación y economias extractivas, investigamos los procesos de acomodación, coloboración, oposición, y posible dominación basadas en perspectivas y prácticas locales. De esta manera nos proponemos extender discusiones de las diferencias radicales en la Amazonía para reconocer también las maneras complejas en que las experiencias indígenas están profundamente integradas en la cultura y política latinoamericana.
Multiperiod Loans, Occasionally Binding Constraints, and Monetary Policy: A Quantitative Evaluation
Authors: BLUWSTEIN KRISTINA , BRZOZA‐BRZEZINA MICHAł , GELAIN PAOLO , KOLASA MARCIN 
Published: June 2020

AbstractWe introduce multiperiod mortgage loans, fixed interest rate, a lower bound constraint on newly granted loans, and a possibly slack collateral constraint, in an otherwise standard Dynamic Stochastic General Equilibrium (DSGE) model with housing. Our nonlinear estimation shows that all those features are important to understand the evolution of mortgage debt during the recent U.S. housing market boom and bust. The transmission of monetary policy becomes dependent on the housing cycle, with weaker effects when house prices are high or start falling sharply. Higher average loan duration makes monetary policy less effective, eventually leading to asymmetric responses to positive and negative monetary shocks.
Subject‐specific muscle properties from diffusion tensor imaging significantly improve the accuracy of musculoskeletal models
Authors: Charles James P. , Grant Barbara , D’Août Kristiaan , Bates Karl T. 
Published: June 2020

AbstractMusculoskeletal modelling is an important platform on which to study the biomechanics of morphological structures in vertebrates and is widely used in clinical, zoological and palaeontological fields. The popularity of this approach stems from the potential to non‐invasively quantify biologically important but difficult‐to‐measure functional parameters. However, while it is known that model predictions are highly sensitive to input values, it is standard practice to build models by combining musculoskeletal data from different sources resulting in ‘generic’ models for a given species. At present, there are little quantitative data on how merging disparate anatomical data in models impacts the accuracy of these functional predictions. This issue is addressed herein by quantifying the accuracy of both subject‐specific human limb models containing individualised muscle force‐generating properties and models built using generic properties from both elderly and young individuals, relative to experimental muscle torques obtained from an isokinetic dynamometer. The results show that subject‐specific models predict isokinetic muscle torques to a greater degree of accuracy than generic models at the ankle (root‐mean‐squared error – 7.9% vs. 49.3% in elderly anatomy‐based models), knee (13.2% vs. 57.3%) and hip (21.9% vs. 32.8%). These results have important implications for the choice of musculoskeletal properties in future modelling studies, and the relatively high level of accuracy achieved in the subject‐specific models suggests that such models can potentially address questions about inter‐subject variations of muscle functions. However, despite relatively high levels of overall accuracy, models built using averaged generic muscle architecture data from young, healthy individuals may lack the resolution and accuracy required to study such differences between individuals, at least in certain circumstances. The results do not wholly discourage the continued use of averaged generic data in musculoskeletal modelling studies but do emphasise the need for to maximise the accuracy of input values if studying intra‐species form–function relationships in the musculoskeletal system.
The relationship between masticatory performance and intakes of foods and nutrients in Japanese male workers: A cross‐sectional study
Authors: Kawashima Bori Fuyoko , Fukuhara Masayo , Masaki Chihiro , Ohta Yuko , Nakamichi Ikuo , Sakata Satoko , Goto Kenichi , Kataoka Shota , Kakuta Satoko , Iwasaki Masanori , Ansai Toshihiro , Hosokawa Ryuji 
Published: June 2020

AbstractBackgroundAlthough many studies have been conducted on the relationship between masticatory performance and nutrient ingestion in the elderly, few large‐scale studies have been carried out using relatively young individuals.ObjectivesThe objective of this study was to clarify the association between the masticatory performance evaluated by the gummy‐jelly test, not by visual examination, and nutrient ingestion state based on the brief self‐administered diet history questionnaire (BDHQ).MethodsThis was a cross‐sectional survey of 540 male workers. Somatometry, blood pressure measurement, blood test and medical interview were performed as a periodic health check‐up. In the dental check‐up, an oral examination, gummy‐jelly test (glucosensor) and survey of ingested food and nutrients using BDHQ were performed. The participants were classified into two groups with low and normal values of masticatory performance. Participants with a score on the gummy‐jelly test below 150 mg/dL or 150 mg/dL or higher were included in the low and normal groups, respectively.ResultsTwo hundred and forty‐eight participants (45.8%) had low masticatory performance, and 292 (53.2%) had normal masticatory performance. The intakes of some minerals and vitamins, such as calcium, vitamin D, vitamin B2, small fish with bones and non‐oily fish, were significantly lower in the low masticatory group than in the normal group. In contrast, the intake of sugar for coffee and tea and that of chicken were significantly higher in the low masticatory group than in the normal group.ConclusionThis study suggested that low masticatory performance can affect nutrient intake, which may cause non‐communicable diseases.
Access to essential medicines to guarantee women's rights to health: The pharmaceutical patents connection
Authors: Mike Jennifer H. M. 
Published: June 2020

AbstractIndubitably, everyone is entitled to the right to a standard of health. While women's rights to health and life are clearly established in legal instruments, having these laws without the fulfilling them will not serve the people they are meant to safeguard. For this reason, this article argues that the right to health and life includes the right to an effective access to available, good quality, safe and effective medicines that are equally affordable to everyone. Essentially, human rights principles, norms and standards provide strong moral support for the consideration of women's access to medicines, in view of the adverse impact of international and national patent law on public health. It is also submitted that ensuring this access to a choice of essential medicines at an affordable price requires the state to ensure that the granting of patent rights to inventors and pharmaceutical companies does not hinder access to essential drugs. In the same vein, the article argues for the design, interpretation and implementation of patent rights to respond to the right to health, life and access to medicines.
Ralstonia solanacearum promotes pathogenicity by utilizing l‐glutamic acid from host plants
Authors: Shen Fangfang , Yin Wenfang , Song Shihao , Zhang Zhihan , Ye Peiyi , Zhang Yong , Zhou Jianuan , He Fei , Li Peng , Deng Yinyue 
Published: June 2020

AbstractRalstonia solanacearum is an important bacterial pathogen that can infect a broad range of plants worldwide. A previous study showed that R. solanacearum could respond to exogenous organic acids or amino acids to modulate cell motility. However, it was unclear whether R. solanacearum uses these compounds to control infection. In this study, we found that R. solanacearum GMI1000 uses host plant metabolites to enhance the biosynthesis of virulence factors. We demonstrated that l‐glutamic acid from host plants is the key active component associated with increased extracellular polysaccharide production, cellulase activity, swimming motility, and biofilm formation in R. solanacearum GMI1000. In addition, l‐glutamic acid also promoted colonization of R. solanacearum cells in the roots and stems of tomato plants and accelerated disease incidence. Furthermore, genetic screening and biochemical analysis suggested that RS01577, a hybrid sensor histidine kinase/response regulator, is involved in l‐glutamic acid signalling in R. solanacearum. Mutations in RS01577 and exogenous addition of l‐glutamic acid to the GMI1000 wild‐type strain had overlapping effects on both the transcriptome and biological functions of R. solanacearum, including on motility, biofilm formation, and virulence. Thus, our results have established a new interaction mechanism between R. solanacearum and host plants that highlights the complexity of the virulence regulation mechanism and may provide new insight into disease control.
Fazlur Rahman’s Influence on Contemporary Islamic Thought
Authors: Akbar Ali 
Published: June 2020

AbstractThis article examines the influence of Fazlur Rahman, one of the most widely quoted scholars among contemporary Muslim modernists, on contemporary Islamic thought. It explores how Rahman’s ideas about revelation and the interpretation of the Qurʾān have influenced some contemporary Muslim scholars of the late twentieth and early twenty‐first centuries, such as Abdolkarim Soroush, Arash Naraqi, Abdullah Saeed, Nurcholish Madjid, Farid Esack and Amina Wadud, and thus have given rise – whether directly or indirectly – to such schools of thought as Islamic liberation theology and feminist exegesis of the Qurʾān. The article also provides a critical evaluation the thought of Fazlur Rahman, and examines how its shortcomings have been rectified by his followers. The article ends with some recommendations to contextualist scholars about Qurʾānic justice and its relation with our contemporary understandings of justice.
Estimating canopy gross primary production by combining phloem stable isotopes with canopy and mesophyll conductances
Authors: Vernay Antoine , Tian Xianglin , Chi Jinshu , Linder Sune , Mäkelä Annikki , Oren Ram , Peichl Matthias , Stangl Zsofia R. , Tor‐Ngern Pantana , Marshall John D. 
Published: June 2020

AbstractGross primary production (GPP) is a key component of the forest carbon cycle. However, our knowledge of GPP at the stand scale remains uncertain, because estimates derived from eddy covariance (EC) rely on semi‐empirical modelling and the assumptions of the EC technique are sometimes not fully met. We propose using the sap flux/isotope method as an alternative way to estimate canopy GPP, termed GPPiso/SF, at the stand scale and at daily resolution. It is based on canopy conductance inferred from sap flux and intrinsic water‐use efficiency estimated from the stable carbon isotope composition of phloem contents. The GPPiso/SF estimate was further corrected for seasonal variations in photosynthetic capacity and mesophyll conductance. We compared our estimate of GPPiso/SF to the GPP derived from PRELES, a model parameterized with EC data. The comparisons were performed in a highly instrumented, boreal Scots pine forest in northern Sweden, including a nitrogen fertilized and a reference plot. The resulting annual and daily GPPiso/SF estimates agreed well with PRELES, in the fertilized plot and the reference plot. We discuss the GPPiso/SF method as an alternative which can be widely applied without terrain restrictions, where the assumptions of EC are not met.
Photogrammetric terminology: fourth edition
Authors: Granshaw Stuart I. 
Published: June 2020

AbstractThis contribution offers a considerably expanded and updated version of the previous three editions of this guide to terms used in the photogrammetric literature. The aim is to assist authors in preparing contributions for publication and readers in the wider geomatics community in understanding current photogrammetric and related terminology and abbreviations. The paper is recognised as an ISPRS document (https://www.isprs.org/documents/).
Geometric modelling and calibration of a spherical camera imaging system
Authors: Lichti Derek D. , Jarron David , Tredoux Wynand , Shahbazi Mozhdeh , Radovanovic Robert 
Published: June 2020

AbstractThe Ladybug5 is an integrated, multi‐camera system that features a near‐spherical field of view. It is commonly deployed on mobile mapping systems to collect imagery for 3D reality capture. This paper describes an approach for the geometric modelling and self‐calibration of this system. The collinearity equations of the pinhole camera model are augmented with five radial lens distortion terms to correct the severe barrel distortion. Weighted relative orientation stability constraints are added to the self‐calibrating bundle adjustment solution to enforce the angular and positional stability between the Ladybug5’s six cameras. Centimetre‐level 3D reconstruction accuracy can be achieved, with image‐space precision and object‐space accuracy improved by 92%and 93%, respectively, relative to a two‐term lens distortion model. Sub‐pixel interior orientation stability and millimetre‐level relative orientation stability were also demonstrated over a 10‐month period.
The effects of dispositional restrictiveness on physiological markers of challenge and threat during a hypothetical transitional period in romantic relationships
Authors: Tudder Ashley , Gresham Abriana M. , Peters Brett J. , Reis Harry T. , Jamieson Jeremy P. 
Published: June 2020

AbstractRestrictiveness, a component of relationship dominance associated with monitoring and regulating partners' behavior, is a risk factor and accelerant of Intimate Partner Violence (IPV). Few studies, however, have examined in vivo physiological responses associated with restrictiveness. Toward this end, 105 romantic couples (N = 210) completed measures of restrictiveness and had their physiological responses recorded in anticipation of and during a dyadic interaction in which they discussed a hypothetical transitional period in which one person (thediscloser) revealed to their partner (theresponder) that they had just gotten into their dream school or was offered their dream job. Individuals high (vs. low) in restrictiveness exhibited physiological responses indicative of greater psychological challenge (e.g., elevated cardiac output and lower peripheral resistance) in anticipation of and during the conversation. In contrast, their partners exhibited greater physiological indicators of psychological threat in anticipation of (but not during) the conversation, particularly when assigned to the discloser role. Exploratory analyses of communication behaviors corroborated the physiological data. This research integrates the biopsychosocial model of challenge and threat with theories of relationship power and dominance to demonstrate the physiological manifestations of a well‐known risk factor for IPV in romantic relationships and interpersonal restrictiveness.