bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bcl2-induced DNA replication stress promotes lung carcinogenesis in response to space radiation
Authors: Xie Maohua , Park Dongkyoo , Sica Gabriel L , Deng Xingming 
Published: March 2020

Abstract
Space radiation is characterized by high-linear energy transfer (LET) ionizing radiation. The relationships between the early biological effects of space radiation and the probability of cancer in humans are poorly understood. Bcl2 not only functions as a potent antiapoptotic molecule but also as an oncogenic protein that induces DNA replication stress. To test the role and mechanism of Bcl2 in high-LET space radiation-induced lung carcinogenesis, we created lung-targeting Bcl2 transgenic C57BL/6 mice using the CC10 promoter to drive Bcl2 expression selectively in lung tissues. Intriguingly, lung-targeting transgenic Bcl2 inhibits ribonucleotide reductase activity, reduces dNTP pool size and retards DNA replication fork progression in mouse bronchial epithelial cells. After exposure of mice to space radiation derived from 56iron, 28silicon or protons, the incidence of lung cancer was significantly higher in lung-targeting Bcl2 transgenic mice than in wild-type mice, indicating that Bcl2-induced DNA replication stress promotes lung carcinogenesis in response to space radiation. The findings provide some evidence for the relative effectiveness of space radiation and Bcl-2 at inducing lung cancer in mice.
A Digital Postracial Parity? Black Women’s Everyday Resistance and Rethinking Online Media Culture
Authors: Maragh-Lloyd Raven 
Published: March 2020

AbstractThis article examines and critiques digital media culture and its embedded postracial logics through the resistance strategies of Black women online. Specifically, I am interested in everyday resistance strategies as “seemingly innocuous” communication, which is understood from theorizations of “hidden transcripts” that black publics utilize to counteract dominance. In order to explore “everyday resistance” I employed focus groups with 20 Black women and present patterns of resistance strategies online, such as visual signifiers and posting news articles. Secondly, I interrogate how these resistance strategies “talk back” to and circumvent the underpinnings of digital media culture through the postracial logics of individuality and networked influence. Ultimately, Black women’s interconnected identities reveal the flaws of digital culture as postracial by demonstrating their resistance strategies that must work around any assumption of a “postracial parity.”
Passive acoustic monitoring effectively detects Northern Spotted Owls and Barred Owls over a range of forest conditions
Authors: Duchac Leila S , Lesmeister Damon B , Dugger Katie M , Ruff Zachary J , Davis Raymond J 
Published: March 2020

Abstract
Passive acoustic monitoring using autonomous recording units (ARUs) is a fast-growing area of wildlife research especially for rare, cryptic species that vocalize. Northern Spotted Owl (Strix occidentalis caurina) populations have been monitored since the mid-1980s using mark–recapture methods. To evaluate an alternative survey method, we used ARUs to detect calls of Northern Spotted Owls and Barred Owls (S. varia), a congener that has expanded its range into the Pacific Northwest and threatens Northern Spotted Owl persistence. We set ARUs at 30 500-ha hexagons (150 ARU stations) with recent Northern Spotted Owl activity and high Barred Owl density within Northern Spotted Owl demographic study areas in Oregon and Washington, and set ARUs to record continuously each night from March to July, 2017. We reviewed spectrograms (visual representations of sound) and tagged target vocalizations to extract calls from ~160,000 hr of recordings. Even in a study area with low occupancy rates on historical territories (Washington’s Olympic Peninsula), the probability of detecting a Northern Spotted Owl when it was present in a hexagon exceeded 0.95 after 3 weeks of recording. Environmental noise, mainly from rain, wind, and streams, decreased detection probabilities for both species over all study areas. Using demographic information about known Northern Spotted Owls, we found that weekly detection probabilities of Northern Spotted Owls were higher when ARUs were closer to known nests and activity centers and when owls were paired, suggesting passive acoustic data alone could help locate Northern Spotted Owl pairs on the landscape. These results demonstrate that ARUs can effectively detect Northern Spotted Owls when they are present, even in a landscape with high Barred Owl density, thereby facilitating the use of passive, occupancy-based study designs to monitor Northern Spotted Owl populations.
Zinc concentrations in teeth of female walruses reflect the onset of reproductive maturity
Authors: Clark Casey T , Horstmann Lara , Misarti Nicole 
Published: March 2020

AbstractAge at maturity is an important parameter in many demographic models and, for some species, can be difficult to obtain using traditional methods. Incremental growth structures act as biological archives, recording information throughout an organism’s life and possibly allowing for the reconstruction of life history events. Concentrations of zinc (Zn) in animal tissues are known to be linked to life history, physiology and reproduction and may be retained in incremental growth structures. This study reconstructed lifetime Zn concentrations in teeth (n = 93) of female Pacific walruses (Odobenus rosmarus divergens) collected from 1932–2016. Zn displayed a characteristic pattern of accumulation, with a change point marking the beginning of a lifelong, linear increase in Zn concentrations. We hypothesized that this change point marks the onset of reproductive maturity. The age at which the change point occurred (agecp) was estimated by counting tooth cementum growth layers. These estimates closely matched literature values of timing of first ovulation in female walruses. Total number of ovulations (estimated from ovary corpora counts from paired tooth/ovary specimens) was closely related to reproductive lifespan (total lifespan – agecp; R2 = 0.70). Further, agecp tracked changes in Pacific walrus population size as a proportion of carrying capacity, decreasing when the population was depleted by commercial hunting and peaking when carrying capacity was exceeded. This novel approach will aid walrus management, and is likely applicable to other species, offering a potentially powerful tool for research, management and conservation of wildlife populations.
Update now or later? Effects of experience, cost, and risk preference on update decisions
Authors: Rajivan Prashanth , Aharonov-Majar Efrat , Gonzalez Cleotilde 
Published: March 2020

AbstractInstalling software updates is one of the most important security actions that people can take to protect their computer systems. However, people often delay installing updates. Why would people delay installation of security updates, knowing that these updates may reduce the risk of information loss from attacks? In a laboratory experiment, we studied how people learn to make update decisions from past experiences. In a simulated “work” environment, participants could defend against low probability and high impact losses, by installing a security update. The cost of updates was variable; participants could update immediately for a high cost or wait to update for free, risking increased exposure to attacks and losses. Thus, the optimal decision was to update immediately when the update was made available. The results from our experiment indicate people learn from experience to delay security updates. The cost of the update and individual risk preference both significantly predicted the tendency to delay the update; people with higher willingness to take risks may be more likely to neglect to update, keeping the status quo even when it may be sub-optimal. We discuss the implications of these findings for the design of interventions to reduce delays in update installations.
Host-directed therapies targeting the tuberculosis granuloma stroma
Authors: Hortle Elinor , Oehlers Stefan H 
Published: March 2020

ABSTRACTMycobacteria have co-evolved with their hosts resulting in pathogens adept at intracellular survival. Pathogenic mycobacteria actively manipulate infected macrophages to drive granuloma formation while subverting host cell processes to create a permissive niche. Granuloma residency confers phenotypic antimicrobial resistance by physically excluding or neutralising antibiotics. Host-directed therapies (HDTs) combat infection by restoring protective immunity and reducing immunopathology independent of pathogen antimicrobial resistance status. This review covers innovative research that has discovered ‘secondary’ symptoms of infection in the granuloma stroma are actually primary drivers of infection and that relieving these stromal pathologies with HDTs benefits the host. Advances in our understanding of the relationship between tuberculosis and the host vasculature, haemostatic system and extracellular matrix reorganisation are discussed. Preclinical and clinical use of HDTs against these stromal targets are summarised.
Swedish Feminist Foreign Policy and “Gender Cosmopolitanism”
Authors: Bergman Rosamond Annika 
Published: March 2020

AbstractGender justice and equality have risen to prominence in the constitution of foreign and security policy. This article locates the analysis of feminist foreign policy (FFP) within the wider context of Sweden's state feminist tradition as well as its pursuit of “gender cosmopolitanism” in global politics. Both “gender cosmopolitanism” and Sweden's state feminist tradition provided fertile ground for the formal adoption of FFP in 2014. The article employs poststructural discursive techniques that enable the identification of the statist feminist and cosmopolitan foundations of feminist foreign policy. More specifically, the article provides a discursive analysis of the ethical and feminist ambitions, normative contents, and pitfalls of FFP. Though FFP is grounded in other-regarding cosmopolitan care for vulnerable women and girls beyond borders, it exhibits a range of pitfalls and inconsistencies, such as equating gender with women and, at times, privileging results-oriented strategies over thoroughgoing gender analysis of structural injustices such as gendered violence. The article ends with a discussion of Sweden's attempts to translate the feminist and cosmopolitan contents of FFP commitments into policy practice, with a focus on the eradication of gender-based violence.
The Paradox of Dementia and Driving Cessation: “It’s a Hot Topic,” “Always on the Back Burner”
Authors: Stasiulis Elaine , Rapoport Mark J , Sivajohan Brintha , Naglie Gary 
Published: March 2020

Abstract

Background and Objectives
Despite the well-recognized difficulty that persons with dementia and family carers experience in the decision making and transition to nondriving, there are few interventions and resources to support them. As part of our ongoing research to develop a driving cessation toolkit that addresses this gap, we sought to examine the context-specific factors relevant to its effective implementation in settings that support older adults with dementia.

Research Design and Methods
A qualitative descriptive approach was used to explore the perspectives of Alzheimer Society (AS) staff in their work of supporting people with dementia and family carers within the context of driving cessation. Individual in-depth interviews were conducted with 15 AS staff members in 4 Canadian provinces. Data were examined using interpretative thematic analysis.

Results
The study results revealed an overarching paradox that despite the importance of driving cessation in people with dementia, it continues to be largely avoided at the individual and system levels. This is explored via the themes of (a) paradox of importance and avoidance identified in AS settings; (b) lack of awareness and understanding about dementia and driving among people with dementia and family carers; (c) distress and avoidance rooted in ongoing system issues; and (d) moving driving cessation to the “front burner.”

Discussion and Implications
Viewed through the emerging social health paradigm, which focuses on the social and emotional consequences of dementia, our results highlight the urgent need to mobilize our communities, medical education systems, and transportation authorities to finally resolve the dementia and driving cessation paradox.
Chromosome-level genome assembly and annotation of the loquat (Eriobotrya japonica) genome
Authors: Jiang Shuang , An Haishan , Xu Fangjie , Zhang Xueying 
Published: March 2020

Abstract

Background
The loquat (Eriobotrya japonica) is a species of flowering plant in the family Rosaceae that is widely cultivated in Asian, European, and African countries. It blossoms in the winter and ripens in the early summer. The genome of loquat has to date not been published, which limits the study of molecular biology in this cultivated species. Here, we used the third-generation sequencing technology of Nanopore and Hi-C technology to sequence the genome of Eriobotrya.

Findings
We generated 100.10 Gb of long reads using Oxford Nanopore sequencing technologies. Three types of Illumina high-throughput sequencing data, including genome short reads (47.42 Gb), transcriptome short reads (11.06 Gb), and Hi-C short reads (67.25 Gb), were also generated to help construct the loquat genome. All data were assembled into a 760.1-Mb genome assembly. The contigs were mapped to chromosomes by using Hi-C technology based on the contacts between contigs, and then a genome was assembled exhibiting 17 chromosomes and a scaffold N50 length of 39.7 Mb. A total of 45,743 protein-coding genes were annotated in the Eriobotrya genome, and we investigated the phylogenetic relationships between the Eriobotrya and 6 other Rosaceae species. Eriobotrya shows a close relationship with Malus and Pyrus, with the divergence time of Eriobotrya and Malus being 6.76 million years ago. Furthermore, chromosome rearrangement was found in Eriobotrya and Malus.

Conclusions
We constructed the first high-quality chromosome-level Eriobotrya genome using Illumina, Nanopore, and Hi-C technologies. This work provides a valuable reference genome for molecular studies of the loquat and provides new insight into chromosome evolution in this species.
Sex-specific autosomal genetic effects across 26 human complex traits
Authors: Lin Wan-Yu , Chan Chang-Chuan , Liu Yu-Li , Yang Albert C , Tsai Shih-Jen , Kuo Po-Hsiu 
Published: March 2020

AbstractPrevious studies have shown that men and women have different genetic architectures across many traits. However, except waist-to-hip ratio (WHR) and waist circumference (WC), it remains unknown whether the genetic effects of a certain trait are weaker or stronger on men/women. With ~18 000 Taiwan Biobank subjects, we comprehensively investigate sexual heterogeneity in autosomal genetic effects, for traits regarding cardiovascular health, diabetes, kidney, liver, anthropometric profiles, blood, etc. ‘Gene-by-sex interactions’ (G $\times$ S) were detected in 18 out of 26 traits, each with an interaction P-value (${{P}}_{{INT}}$) less than $0.05/104={0.00048}$, where 104 is the number of tests conducted in this study. The most significant evidence of G $\times$ S was found in WHR (${{P}}_{{INT}}$ = 3.2 $\times{{10}}^{-{55}}$) and WC (${{P}}_{{INT}}$ = 2.3$\times{{10}}^{-{41}}$). As a novel G$\times$S investigation for other traits, we here find that the autosomal genetic effects are weaker on women than on men, for low-density lipoprotein cholesterol (LDL-C), uric acid (UA) and diabetes-related traits such as fasting glucose and glycated hemoglobin. For LDL-C and UA, the evidence of G$\times$S is especially notable in subjects aged less than 50 years, where estrogen can play a role in attenuating the autosomal genetic effects of these two traits. Men and women have systematically distinct environmental contexts caused by hormonal milieu and their specific society roles, which may trigger diverse gene expressions despite the same DNA materials. As many environmental exposures are difficult to collect and quantify, sex can serve as a good surrogate for these factors.
Multi-scale vector quantization with reconstruction trees
Authors: Cecini Enrico , De Vito Ernesto , Rosasco Lorenzo 
Published: March 2020

Abstract
We propose and study a multi-scale approach to vector quantization (VQ). We develop an algorithm, dubbed reconstruction trees, inspired by decision trees. Here the objective is parsimonious reconstruction of unsupervised data, rather than classification. Contrasted to more standard VQ methods, such as $k$-means, the proposed approach leverages a family of given partitions, to quickly explore the data in a coarse-to-fine multi-scale fashion. Our main technical contribution is an analysis of the expected distortion achieved by the proposed algorithm, when the data are assumed to be sampled from a fixed unknown distribution. In this context, we derive both asymptotic and finite sample results under suitable regularity assumptions on the distribution. As a special case, we consider the setting where the data generating distribution is supported on a compact Riemannian submanifold. Tools from differential geometry and concentration of measure are useful in our analysis.
Asymptotic Properties of the Solutions to the Vlasov–Maxwell System in the Exterior of a Light Cone
Authors: Bigorgne Léo 
Published: March 2020

Abstract
This paper is concerned with the asymptotic behavior of small data solutions to the three-dimensional Vlasov–Maxwell system in the exterior of a light cone. The plasma does not have to be neutral, and no compact support assumptions are required on the data. In particular, the initial decay in the velocity variable of the particle density is optimal and we only require an $L^2$ bound on the electromagnetic field with no additional weight. We use vector field methods to derive improved decay estimates in null directions for the electromagnetic field, the particle density, and their derivatives. In contrast with [ 2], where we studied the behavior of the solutions in the whole spacetime, the initial data have less decay and we do not need to modify the commutation vector fields of the relativistic transport operator. To control the solutions under these assumptions, we crucially use the strong decay satisfied by the particle density in the exterior of the light cone, null properties of the Vlasov equation, and certain hierarchies in the energy norms.
A Rigid Hyperfinite Type II1 Factor
Authors: Farah Ilijas , Hirshberg Ilan 
Published: March 2020

Abstract
We show that it is relatively consistent with Zermelo-Fraenkel set theory with the axiom of choice that there exists a hyperfinite type $\textrm{II}_1$-factor of density character $\aleph _1$ that is not isomorphic to its opposite, does not have any outer automorphisms, and has trivial fundamental group.
The House We Live In: Religio-Racial Theories and the Study of Religion
Authors: Weisenfeld Judith 
Published: March 2020

AbstractThis article reviews the origins and goals of the religio-racial framework that grounds the approach to early twentieth-century Black new religious movements in New World A-Coming. It discusses how the articles in the roundtable offer case studies that extend the framework of “religio-racial identity” to model approaches for locating the analysis of connections between race and religion as central to the work of religious studies.
Centering Black Catholic Religio-Racial Identity, Revealing White Catholicism
Authors: Cressler Matthew J 
Published: March 2020

AbstractIn New World A-Coming: Black Religion and Racial Identity during the Great Migration, Judith Weisenfeld presents numerous instances when members of religio-racial movements contested the racial classificatory system provided by the federal government and confronted state administrators with their own alternative religio-racial identities. For Weisenfeld, these sorts of exchanges highlight, first and foremost, Black agency in religio-race making. But, as she indicates, they also make visible the contours of religio-racial whiteness as state administrators struggled to defend the status quo. In this article, I focus on how Black contestation and confrontation with racial hierarchy can reveal the racial whiteness operating beneath the surface of normative “religion.” This article draws on sources ranging from a police surveillance report to angry letters from white Catholics in order to argue that Black Catholics interrupted the presumed normativity of white Catholic religious life and, in so doing, revealed white Catholicism as a racial formation.
Azithromycin susceptibility testing for Salmonella enterica isolates: discordances in results using MIC gradient strips
Authors: Goldblatt Jennifer , Ward Andrew , Yusuf Mohammed , Day Martin , Godbole Gauri , Morris-Jones Stephen 
Published: March 2020

Abstract

Background
Azithromycin resistance is emerging in typhoidal Salmonella. Confirmation of azithromycin MIC is the most frequent antibiotic susceptibility request made to the Gastrointestinal Bacteria Reference Unit (GBRU) laboratory in England by local diagnostic laboratories.

Objectives
(i) Determine concordance between local diagnostic and reference laboratory estimations of azithromycin MIC by gradient strip in Salmonella enterica serovars Typhi and Paratyphi. (ii) Consider causes of variation.

Methods
Isolates from patients with enteric fever attending a central London hospital between May 2011 and April 2019 were tested for azithromycin susceptibility using gradient strips, according to EUCAST methodology. Matched local diagnostic and reference laboratory estimations of azithromycin and ciprofloxacin (as a comparator) MICs were included; concordance in estimations was examined.

Results
Local diagnostic laboratory readings overestimated azithromycin MIC values compared with the reference laboratory, resulting in poor concordance in susceptibility/resistance attribution (concordant susceptibility interpretation in 8/19, κ = 0). In contrast, ciprofloxacin MIC estimation demonstrated superior concordance (concordant susceptibility interpretation in 16/17, κ = 0.85). None of the isolates was resistant to azithromycin at the reference laboratory and no known genes associated with azithromycin resistance were detected in any isolate using WGS.

Conclusions
Overestimation of azithromycin resistance is likely to be due to difficulty in interpreting the point of intersection of the ‘trailing edge’ with the gradient strip, used to determine MIC. We advise local diagnostic laboratories to review their experience and consider adopting a ‘second reader’ system to mitigate this.