bluuebunny/crossref_metadata_2025_split huggingface dataset:
ВПЛИВ ХІМІЧНОГО СКЛАДУ НА РІДИННОПЛИННІСТЬ ФТОРФЛОГОПІТОВИХ РОЗПЛАВІВ
Authors: Кузьменко О. А. , Малявін А. Г. , Щерецький В. О. , Затуловський А. С. 
Published: December 2019

Розглянуто, як впливає на рідинноплинність фтофлогопітового розплаву склад фторфлогопіту. Встановлено, що рідинноплинність фторфлогопітових розплавів збільшується із збільшенням температури та зменшенням алюмосилікатного модуля.При температурі заливки у фторфлогопітових розплавів у ливарні форми в інтервалі 1400 – 1450 °С рідинноплинність складає 360 – 480 мм. Такі високі значення рідиноплинності забезпечують нормальне заповнення ливарних форм, та отримання якісних виливків.Показано, що рідинноплинність розплавів, які вивчалися, наближається до рідинноплинності вуглецевої сталі та в 3-4 рази перевищує рідинноплинність базальтових розплавів, займаючи проміжне положення між розплавами базальту та рідким чавуном. Це дозволяє отримувати, як прості, так і фасонні виливки складної конфігурації із застосуванням технологічних засобів ливарного виробництва.
ОТРИМАННЯ, СТРУКТУРА ТА ДЕЯКІ ВЛАСТИВОСТІ СПЛАВІВ Al–Fe
Authors: Степанчук А. М. , Похилько Б. А. , Хващевський М. О. 
Published: December 2019

Досліджено закономірності формування структури та властивостей литих сплавів Al +15 % Fe та Al + 40 % Fe залежно від умов отримання, які мають перспективу використання як вихідних матеріалів для отримання антифрикційних матеріалів триботехнічного призначення. Встановлено, що структура матеріалів двофазна і складається матричної фази на основі алюмінію та інтерметаліду Al3Fe для сплаву з вмістом заліза 15 % і Al.Fe для сплаву з вмістом заліза 40 %. Розмір фазових складових залежить від швидкості охолодження розплаву і зменшується з її збільшенням, а їх мікротвердість не змінюється. Твердість сплавів збільшується зі збільшенням вмісту заліза в них і зменшенням швидкості охолодження при кристалізації.
INFLUÊNCIA DE REGULADORES DE CRESCIMENTO E DO TIPO DE EXPLANTE NA MORFOGÊNESE in vitro DE Hancornia speciosa Gomes
Authors: OLIVEIRA Kívia Soares de , Freire Fúlvio Aurélio de Morais , Aloufa Magdi Ahmed Ibrahim 
Published: December 2019

A mangabeira (Hancornia speciosa Gomes), pertencente à família Apocynaceae, é uma espécie nativa do Cerrado e dos tabuleiros costeiros do Nordeste, e possui grande importância socioeconômica, ambiental e cultural. O objetivo deste trabalho foi avaliar a influência de diferentes concentrações de 6-benzilaminopurina (BAP) e ácido indolbutírico (AIB) e do tipo de explante sobre a morfogênese in vitro de H. speciosa. Para isso, explantes nodais e apicais foram inoculados em meio MS básico e em MS suplementado com 1,5; 2,5 e 3,5 mg.L-1 de BAP e 1,25; 2,5 e 3,0 mg.L-1 de AIB. As variáveis observadas foram: formação de brotos, número de brotos por explante, número de nós por brotação, contaminação, sobrevivência, formação de raízes, número médio de raízes e presença de calos. Constatou-se que explantes de ápices caulinares, na ausência de BAP, apresentam-se mais responsivos em relação à taxa de multiplicação in vitro e indução de brotações. A rizogênese a partir de ápices caulinares e segmentos nodais não foi favorecida nas concentrações de AIB utilizadas. Entretanto, o uso de 3,0 mg.L-1 de AIB induz a formação de maior número de raízes, aumenta a calogênse e sobrevivência de segmentos nodais e apicais de H. speciosa.
Palavras-chave: Apocynaceae; citocinina; auxina.
VIVÊNCIAS SOBRE O PROCESSO DE TRABALHO DAS EQUIPES DE SAÚDE DA FAMÍLIA DO MUNICÍPIO DE GURUPI-TO
Authors: Da Silva Jeann Bruno Ferreira , Valadão Reis Thaís , De Sousa Rocha Hericácia 
Published: December 2019

Dentre os desafios diários presentes no processo de trabalho dos profissionais da Atenção Básica, destacam-se as vivências de situações referentes à qualidade no atendimento aos usuários e articulação de saberes com os demais profissionais da saúde em prol do bem estar dos pacientes. Objetivou-se compreender a percepção dos coordenadores das Equipes de Saúde da Família/ESF de Gurupi-TO sobre seu processo de trabalho. Trata-se de um estudo qualitativo, de caráter exploratório-descritivo. A amostra foi composta por 10 enfermeiros coordenadores das ESF no município de Gurupi-TO. Os dados foram coletados em único momento no mês de outubro de 2017 com um coordenador de cada UBS por meio de roteiro de entrevista semiestruturada, analisados e categorizados segundo a análise de conteúdo de Bardin. Os resultados apontaram que 50% dos enfermeiros não se encontram satisfeitos com a estrutura física das UBS que trabalham. Concluiu-se que a maioria dos profissionais se encontra descontente com as condições oferecidas no seu processo de trabalho, como a estrutura física inadequada à demanda, déficit de profissionais, excesso de atribuições e ausência de veículos oficiais para locomoção da zona urbana para a rural.
Palavras-chave: Processo de trabalho; Profissionais da Saúde; Atenção Básica.
A Hierarchical Intrusion Detection System for Industrial Control Networks based on EtherNet/IP
Authors: Yu Wenbin , Wang Yiyin , Song Lei 
Published: December 2019

Standard Ethernet (IEEE 802.3 and the TCP/IP protocol suite) is gradually applied in industrial control system (ICS) with the development of information technology. It	breaks the natural isolation of ICS, but contains no security mechanism. A modified intrusion detection system (IDS), which	is strongly correlated to specific industrial scenario, is necessary for modern ICS. On the one hand, this paper outlines attack models, including infiltration attacks and our creative forging attack. On the other hand, we proposes a hierarchical IDS, which contains a traffic prediction model and an anomaly detection model. The traffic prediction model, which is based on autoregressive integrated moving average (ARIMA), can forecast the traffic of ICS network in the short term and precisely detect the infiltration attacks according to abnormal changes in traffic pattern. The anomaly detection model using one-class support vector machine (OCSVM) is able to detect malicious control instructions by analyzing the key field in EtherNet/IP packets. The experimental results show that the hierarchical IDS has an outstanding performance in detecting infiltration attacks and forging attack compared with other two innovative IDSs.
MODEL PENGELOLAAN KESELAMATAN KERJA NELAYAN DI PALABUHANRATU, KABUPATEN SUKABUMI
Authors: Purwangka Fis , Wisudo Sugeng Hari , Iskandar Budhi H. , Haluan Jonh 
Published: December 2019

Proses keselamatan dan kesehatan kerja seperti proses manajemen pada umumnya adalah penerapan berbagai fungsi manajemen, yaitu perencanaan, pelaksanaan dan pengawasan.Tujuan dari penelitian ini adalah menginventarisasi dan mengidentifikasi aspek-aspek yang terkait dengan manajemen keselamatan kerja nelayan serta membangun model manajemen keselamatan kerja nelayan dari kondisi yang terjadi. Pada penelitian ini digunakan metode berfikir secara sistem (systems thinking) dengan pendekatan metodologi sistem lunak (soft systems methodology). Hasil inventarisasi menunjukkan bahwa permasalahan dalam manajemen keselamatan kerja nelayan di Palabuhanratu umumnya terkait pengorganisasian dan pengelolaan secara terpadu. Pengelolaan manajemen keselamatan kerja nelayan menunjukkan ciri-ciri tidak sistemik dan ciri-ciri organisasi yang mengalami ketidakmampuan belajar.Model Konseptual Pengorganisasian Pengelolaan Sistem Manajemen Keselamatan dan Kesehatan Kerja (SMK3) dapat diimplementasikan dengan kondisi adanya perencanaan dan kebijakan yang mengatur tugas dan wewenang lembaga yang terlibat, adanya mekanisme komunikasi yang mudah dipahami, dibentuknya sistem pengawasan yang terukur, serta komitmen dari semua bagian yang terlibat. Model konseptual pengelolaan secara terpadu SMK3 dapat diimplementasikan dengan kondisi adanya komitmen dari semua lembaga yang terlibat, mekanisme komunikasi, koordinasi, dan keterbukaan informasi, dilakukannya pengawasan bersama dan kesetaraan kelembagaan dan kewenangan serta pelayanan yang terukur.
Oxaliplatin resistance is enhanced by saracatinib via upregulation Wnt-ABCG1 signaling in hepatocellular carcinoma
Authors: Liao Xia , Song Ge , Xu Zihan , Bu Yang , Chang Fan , Jia Fengan , Xiao Xuelian , Ren Xuejiao , Zhang Mei , Jia Qingan 
Published: December 2019

Abstract
Background: Chemo-resistance in hepatocellular carcinoma (HCC) is a major problem, and acquired drug resistance prevents cancer therapies from achieving complete responses. Molecular targeting therapy presents an opportunity to impede tumor through combination or sequential therapy, while the accurate effect is vague.
Methods: The efficacy of combinations between oxaliplatin and anti-cancer molecular targeting drugs was screened. Strangely, the combined chemotherapy with oxaliplatin and saracatinib induced significantly antagonistic effects. Then the antitumor effects of combined treatment with saracatinib and oxaliplatin were confirmed in wide type HCC as well as in saracatinib- and oxaliplatin-resistant HCC. RNA sequencing was used to explore the resistance mechanism, and the roles of ABCG1 and Wnt signaling in oxaliplatin resistance were confirmed.
Results: Chemotherapy with oxaliplatin and saracatinib individually induced strong anti-HCC effects, while combined or sequential treatment of HCC cells with these two drugs exhibited reduced efficacy compared to treatment with the single drugs. And it was saracatinib treatment caused oxaliplatin resistance. RNA sequencing revealed 458 genes that were altered by treatment with saracatinib and oxaliplatin. Of these, the gene encoding the ATP-binding cassette transporter G1 ABCG1 and Wnt-associated genes were significantly upregulated. Upregulation of ABCG1 and oxaliplatin resistance were associated with activation of Wnt signaling. Interference with ABCG1 expression or inhibition of Wnt signaling resulted in reversal of the saracatinib-induced oxaliplatin resistance in HCC.
Conclusions: These studies demonstrated that combined or sequential chemotherapy with oxaliplatin and saracatinib reduced antitumor efficacy, and this antagonism was attributed to the activation of Wnt signaling and upregulation of ABCG1 by saracatinib.
The efficacy and safety of 'Antianxiety Granule' for anxiety disorder: A multicentre, randomized, double-blind, placebo-controlled, parallel-group trial
Authors: Sha Zhongwei , Hou Yiping , Xue Chunchun , Li Ou , Li Zhimin , Wang Huiru , Zhang Wenjing , Xu Jian 
Published: December 2019

Abstract
Background: Anxiety disorders are the most prevalent class of lifetime disorders in China, and generalized anxiety disorder (GAD) is one of the most common but frequently overlooked anxiety disorders. Conventional pharmacological treatments for GAD have varying degrees of side effects, dependency, and/or withdrawal syndromes. Traditional Chinese Medicine (TCM) therapy is considered a valuable therapeutic option for anxiety disorders and a potentially effective technique to reduce the side effects associated with antipsychotic drugs. This trial aimed to evaluate the clinical efficacy and safety of Antianxiety Granule, a granular Chinese medicine compound, for GAD. Methods/Design: The current work is a multicentre, randomized, double-blind, placebo-controlled, parallel-group clinical trial with a 6-week treatment schedule. The study consists of three periods: a 1- to 7-day screening period, a 6-week primary treatment period, and a 1-week follow-up period. Follow-up assessments will be conducted one week after the last visit with a face-to-face interview or by telephone. The clinical efficacy of Antianxiety Granule for the treatment of GAD will be evaluated by examining the change in the Hamilton anxiety scale (HAMA) score, state-trait anxiety inventory (STAI) score, and TCM symptom scale in GAD patients who receive the daily TCM treatment. Moreover, an intention-to-treat (ITT) analysis will also be used in this randomized controlled trial (RCT). Discussion: Our study is a multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the safety and efficacy of Antianxiety Granule for the treatment of GAD. The results of this trial will provide valuable clinical evidence for the treatment of GAD. Trial registration: The trial was registered with the Chinese Clinical Trial Registry (http://www.chictr.org.cn/showproj.aspx?proj=27210) under the registration number ChiCTR1800016039 on 8 May 2018. The study was approved by the Ethics Committee of the Shanghai Municipal Hospital of Traditional Chinese Medicine (2017SHL-KY-14). Keywords: Generalized anxiety disorder (GAD), Traditional Chinese Medicine (TCM), RCT, Efficacy, Safety
Optimal Location of Subtrochanteric Osteotomy in Total Hip Arthroplasty for Crowe Type IV Developmental Dysplasia of Hip
Authors: Huang Zhe-Yu , Liu Hua , Li Ming , Ling Jing , Zhang Jun-Hui , Zeng Zhi-Min 
Published: December 2019

Abstract
Background When reconstructing a hip with developmental dysplasia and high dislocation, sub-trochanteric shortening osteotomy is typically needed for placing the acetabular component in the appropriate anatomical position. However, the procedure can result in complications such as non-union of the osteotomy. We evaluated the contact area and the coincidence rate between the proximal and distal fragments at different femoral osteotomy levels and lengths. We then determined the optimal location of subtrochanteric femoral shortening transverse osteotomy in patients with unilateral Crowe type IV developmental dysplasia of the hip (DDH). The consistency between the proximal and distal segments was assessed as a possible predictive indicator of the union at the osteotomy site. Methods We retrospectively reviewed 57 patients with unilateral Crowe type IV DDH who underwent X-ray imaging of both hip joints. We labelled the inner and outer diameters of the circular ring as N (mm) and M (mm), respectively. We defined the overlapped area between the proximal and distal ring as contact area S (mm 2 ), and the ratio of contact area to distal ring area as coincidence rate R. Results N varied from 9.8–15.2 mm and M varied from 20.7–24 mm, both demonstrated a decreasing trend in the proximal to distal direction. At osteotomy lengths ranging from 0.5–2 cm, there were no differences in S between the different levels of osteotomy in each group. At osteotomy lengths ≤ 2.5 cm, a significant higher coincidence rate was noted from 2 cm below the lesser trochanter to other positions below the level. At osteotomy lengths from 3–5.5 cm, a significantly higher coincidence rate was observed from the level of 1.5 cm below the lesser trochanter to other positions below the level. Conclusions Our findings suggest that femoral shortening transverse osteotomy at the optimal subtrochanteric level can predictably increase the contact area and coincidence rate, which may contribute to the union at the osteotomy site. Considering the stability of the prostheses, it appears appropriate that osteotomy location should be shifted slightly distally.
Analysis of responder-based endpoints: improving power through utilising continuous components
Authors: Wason James , McMenamin Martina , Dodd Susanna 
Published: December 2019

Abstract
Background
Clinical trials and other studies commonly assess effectiveness of an intervention through use of responder-based endpoints. These classify patients based on whether they meet a number of criteria which often involve continuous variables categorised as being above or below a threshold. The proportion of patients who are responders is estimated and, where relevant, compared between groups. An alternative method called the augmented binary method keeps the definition of the endpoint the same but utilises information contained within the continuous component to increase the power considerably (equivalent to increasing the sample size by >30%). In this article we summarise the method and investigate the variety of clinical conditions that use endpoints to which it could be applied.
Methods
We reviewed a database of Core Outcome Sets (COS) that covered physiological and mortality trial endpoints recommended for collection in clinical trials of different disorders. We identified responder-based endpoints where the augmented binary method would be useful for increasing power.
Results
Out of the 287 COS reviewed, we identified 67 new clinical areas where endpoints were used that would be more efficiently analysed using the augmented binary method. Clinical areas that had particularly high numbers were rheumatology (11 clinical disorders identified), non-solid tumour oncology (10 identified), neurology (9 identified), and cardiovascular (8 identified)
Conclusions
The augmented binary method can potentially provide large benefits in a vast array of clinical areas. Further methodological development is needed to account for some types of endpoint.
Choreographing life-experiences of balance control in people with Parkinson’s disease
Authors: LaGrone Sofie , Joseph Conran , Johansson Hanna , Enberg Birgit , Franzén Erika 
Published: December 2019

AbstractBackground: Parkinson’s disease (PD) is a devastating neurodegenerative disorder. Reduced balance is one of the cardinal symptoms of PD, predisposing people living with PD to experience difficulties with the execution of tasks and activities, as well as hindering their involvement in meaningful life areas. Objective: The aim of this study was to explore how deficits in balance control manifest in everyday life and how it is managed by people with PD (PwPD). Design: Qualitative description was used. Methods: In-depth interviews were conducted with 18 participants, between the ages of 46 to 83 years, with mild to severe PD. Interview transcripts were analyzed using qualitative content analysis, following an inductive approach. Results: One theme emerged from the analysis: Increased planning—choreographing life. Within this overarching theme, two categories were identified, namely Limitations in mobility and New restricted functioning in everyday life, each with 3-4 sub-categories. The categories described how PwPD handled decreased balance control in their everyday life by using motor and cognitive strategies as a consequence of not trusting their body’s capacity to control balance. Activities in everyday life, as well as the ability to partake in leisure and social activities were profoundly affected. Conclusion: People with mild to severe PD used strategies to handle decreased balance and they choreographed their lives around their individual current state of mobility and balance. The knowledge gained from this study can be used to develop targeted interventions addressing the nuances of balance deficits in everyday life.
Detection of minimal residual disease in adult acute myeloid leukemia via CD25
Authors: Wang Wei , Li Yan , Ma Lan , Hu Wen-Qing , Jiang Bin 
Published: December 2019

Abstract
Background
We detected the expression of CD25 in patients with acute myeloid leukemia (AML) to value whether CD25 could be a promising marker for minimal residual disease (MRD).
Methods
Two hundred and twenty bone marrow (BM) specimens from 98 adult patients with AML after chemotherapy were detected using flow cytometry. The expression of CD25 was compared between MRD positive and negative subgroups.
Results
About 38% of patients with MRD were positive for CD25. The mean percentage of CD25-positive cell subpopulation was 58.68% relative to the whole MRD cluster (0.05%-100%). The mean fluorescence index ratio (MFIR) of CD25 in these cell subpopulations was approximately13-fold greater than that in normal myeloblasts. The detection sensitivity of CD25 was as high as 10 -4 . CD25 was also expressed on non-leukemic stem cells that were positive for CD34 and CD38.
Conclusion
CD25, as assessed by flow cytometry, is a promising marker for MRD in patients with AML.
Inhibition of autophagy triggers melatonin-induced apoptosis in glioblastoma cells
Authors: Zhou Nan , Wei Zixuan , Qi Zengxin 
Published: December 2019

Abstract
Background: Autophagy is considered to be another restorative focus for the treatment of brain tumors. Although several research have demonstrated that melatonin induces autophagy in colon cancer and hepatoma cells, there has not been any direct evidence of whether melatonin is capable of inducing autophagy in human glioma cells.
Results: In the present research, we report that melatonin or its agonist, agomelatine, induced autophagy in A172 and U87-MG glioblastoma cells for a concentration-and time-dependent way, which was significantly attenuated by treatment with luzindole, a melatonin receptor antagonist. Furthermore, by suppressing autophagy at the late-stage with bafilomycin A1 and early stage with 3-MA, we found that the melatonin-induced autophagy was activated early, and the autophagic flux was complete. Melatonin treatment alone did not induce any apoptotic changes in the glioblastoma cells, as measured by flow cytometry. Western blot studies confirmed that melatonin alone prominently upregulated the levels of Beclin 1 and LC3 II, which was accompanied by an increase in the expression of Bcl-2, whereas it had no effect on the expression of Bax in the glioblastoma cells. Remarkably, co-treatment with 3-MA and melatonin significantly enhanced the apoptotic cell population in the glioblastoma cells, along with a prominent decrease in the expression of bcl-2 and increase in the Bax expression levels, which collectively indicated that the disruption of autophagy triggers the melatonin-induced apoptosis in glioblastoma cells.
Conclusions: These results provide information indicating that melatonin may act as a common upstream signal between autophagy and apoptosis, which may lead to the development of new therapeutic strategies for glioma.