bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Literary Genizot
Authors: Stroumsa Sarah 
Published: August 2020

Abstract
In his reconstruction of what he believed to be a typical Mediterranean medieval society, Shlomo Dov Goitein gave prime of place to the documentary material found in the Cairo Geniza, and it is primarily through this prism that he sought to analyze the Geniza and the society it mirrored. Focusing, instead, on the literary material permits a different perspective on the genizot. The Cairo Geniza was shaped not only by the Jewish tradition, but also by contemporary practices, perhaps specifically Fāṭimid ones. The level of integration of scientists and philosophers within the broader Islamicate culture often surpassed what is usually described as “symbiosis.” The integration of Jewish intellectuals within this philosophic sub-culture requires that we correct our perception of their place in it, and that we modify our vocabulary accordingly.
Interpreting Islamic Dream Books of the Cairo Genizah
Authors: Villuendas Sabaté Blanca 
Published: August 2020

Abstract
This article is the result of a first-hand exploration of the relevance of the Cairo Genizah as a source for Intellectual history of the Middle Ages. It is not only significant for understanding Jewish thought, previously documented in numerous studies, but also to the Islamic world. Whereas S.D. Goitien’s oeuvre and the groundbreaking work of his disciples widely demonstrated the importance of Genizah documents as historical sources on the Mediterranean region, the relevance of its Islamic/Arabic literature is less often acknowledged. This topic will be addressed in the light of my doctoral research, which examined the legacy of dream interpretation preserved in Genizah fragments of dream books written in Judeo-Arabic during the pre-modern period. After a brief introduction to the history of dream books—manuals for dream interpretation—in the Near East, and to the epistemology of Jewish and Islamic dream interpretation, the main findings of the research will be listed and summarized. Finally, in a detailed case study, a synoptic edition of texts representing the Taʿbīr al-ruʾyā, a brief dream manual attributed to al-Kirmānī, demonstrates the importance of Cairo Genizah manuscripts to the literary history of the composition.
How the Present Can Inform the Past, Part I Ancient and Modern Analogues as Supplementary Evidence in Reconstructing an Ancient Instrument
Authors: Psaroudakēs Stelios 
Published: August 2020

Abstract
The present paper seeks to illustrate ways of making use of ancient and modern analogues in the process of reconstructing an ancient instrument. In particular, I argue that the elliptic organological information provided by the Protocycladic II statuettes of harpists can to a large extent be supplemented by a comparison with extant Pharaonic harps, and the saùng-gauk of Myanmar. The latter can, furthermore, throw light upon the playing technique of the obsolete Protocycladic harp.
Why Do We Believe Humans Matter More than Other Animals?
Authors: Hill Scott , Bertrand Michael 
Published: August 2020

Abstract
Some recent psychological studies suggest that the belief that humans matter more than other animals can be strengthened by cognitive dissonance. Jaquet (forthcoming) argues that some of these studies also show that the relevant belief is primarily caused by cognitive dissonance and is therefore subject to a debunking argument. We offer an alternative hypothesis according to which we are already speciesist but cognitive dissonance merely enhances our speciesism. We argue that our hypothesis explains the results of the studies at least as well as Jaquet’s. We then respond to a series of objections. Along the way, we highlight various respects in which further studies are needed to decide between Jaquet’s hypothesis and ours.
Improvement in the Forecasting of Heavy Rainfall over South China in the DSAEF_LTP Model by Introducing the Intensity of the Tropical Cyclone
Authors: Chenchen Ding , Ren Fumin , Liu Yanan , McBride John L. , Feng Tian 
Published: August 2020

AbstractThe intensity of the tropical cyclone has been introduced into the Dynamical-Statistical-Analog Ensemble Forecast (DSAEF) for Landfalling Typhoon (or tropical cyclone) Precipitation (DSAEF_LTP) model. Moreover, the accumulated precipitation prediction experiments have been conducted on 21 target tropical cyclones with daily precipitation ≥ 100 mm in South China from 2012 to 2016. The best forecasting scheme for the DSAEF_LTP model is identified, and the performance of the prediction is compared with three numerical weather prediction models (the European Centre for Medium-Range Weather Forecasts, the Global Forecast System, and T639). The forecasting ability of the DSAEF_LTP model for heavy rainfall (accumulated precipitation ≥ 250 and ≥100 mm) improves when the intensity of the tropical cyclone is introduced, giving some advantages over the three numerical weather prediction models. The selection of analog tropical cyclones with a maximum intensity (during precipitation over land) equaling to or higher than the initial intensity of the target tropical cyclone gives better forecasts. The prediction accuracy for accumulated precipitation is higher for tropical cyclones with higher intensity and higher observed precipitation, with in both cases positive linear correlations with the threat score.
Sydenham Chorea: Putaminal Enlargement
Authors: Karalok Zeynep Selen , Öztürk Zeynep , Gunes Altan , Gurkas Esra 
Published: August 2020

Background: Our aim in this study was to evaluate the efficacy of magnetic resonance imaging (MRI) studies in the detection of brain regions effected by Sydenham chorea and to determine whether they provided data regarding the pathogenesis of Sydenham chorea. To this end, we assessed basal ganglia structures in Sydenham chorea patients and control group by quantitative MRI volumetric analysis. Methods: Patients with a recent onset of chorea and control subjects matched for age and gender were included in the study. Medical history, laboratory tests, and physical and neurologic examinations were reviewed. All MRIs were considered within normal limits. High-resolution T1-weighted 3D magnetization-prepared rapid acquisition of gradient echo scans were used for quantitative volumetric assessment of the brain via the “volBrain” method. Results: Twenty-four subjects with Sydenham chorea (16 girls and 8 boys, aged between 7 and 16 years) and 35 control subjects were evaluated. Mean age was 11.25 ± 2.89 years for Sydenham chorea patients and 10.58 ± 2.53 years for the controls. No significant difference was found relative to globus pallidus, caudate, and thalamic volumes between patients with Sydenham chorea and controls. The relative mean total, left, and right putamen volumes were significantly larger in patients with Sydenham chorea compared to controls ( P = .003, P = .018, P = .001, respectively). Conclusion: Selective neuroanatomic differences in putamen among other basal ganglia structures and significant increases in size are consistent with a hypothesis of a cross-reactive antibody-mediated inflammation of the putamen as being the pathophysiologic mechanism for this disorder.
The cost-effectiveness of outpatient surgery for primary total hip arthroplasty in the United States: a computer-based cost-utility study
Authors: Rosinsky Philip J , Go Cammille C , Bheem Rishika , Shapira Jacob , Maldonado David R , Meghpara Mitchell B , Lall Ajay C , Domb Benjamin G 
Published: August 2020

Purpose: The purpose of this study was to perform a cost-effectiveness analysis of outpatient versus inpatient total hip arthroplasty (THA) in the USA, considering complication probability and the potential cost of such complications. Methods: A cost-effectiveness analysis was conducted from the societal perspective to evaluate the incremental cost and effectiveness of inpatient THA compared to outpatient THA over a lifetime horizon. Effectiveness was expressed in quality-adjusted life years (QALYs). Costs, expressed in 2019 US dollars, transition probabilities, and health utilities were derived from the literature. The primary outcome was the incremental cost-effectiveness ratio (ICER), with a willingness to pay (WTP) threshold set at $50,000/QALY. 1-way and probabilistic sensitivity analyses was performed to evaluate the effect of the various variables on the model. Results: In the base case, inpatient THA was more effective in terms of total utility (10.36 vs. 10.30 QALY), but also more costly ($48,155 ± 1673 vs. $43,288 ± 1, 606 for Medicare) than outpatient THA. Even with a lifetime horizon, the ICER was $81,116 per QALY and $140,917 per QALY for Medicare and private payer insurance, respectively, which is higher than the willingness to pay threshold. 1-way sensitivity analyses indicated that the variables having the most influence on the model were the utility of inpatient and outpatient THA and cost of inpatient and outpatient THA. Conclusions: This model determined that for a WTP threshold set at $50,000/QALY, outpatient THA is more cost-effective than inpatient THA from a societal perspective. Despite this, surgeons must weigh clinical factors first and foremost in determining if an individual patient can be safely operated on in the outpatient setting.
Cerebral blood flow in dystonia due to pantothenate kinase-associated neurodegeneration
Authors: Stoeter Peter , Roa-Sanchez Pedro , Gonzalez Cesar F , Speckter Herwin , Oviedo Jairo , Bido Pamela 
Published: August 2020

Background and purpose The aim of this study was to look for deviations of cerebral perfusion in patients suffering from pantothenate kinase-associated neurodegeneration, where the globus pallidus is affected by severe accumulation of iron. Material and methods Under resting conditions, cerebral blood flow was measured by the magnetic resonance imaging technique of arterial spin labelling in cortical areas and basal ganglia in eight pantothenate kinase-associated neurodegeneration patients and 14 healthy age-matched control subjects and correlated to T2* time of these areas and – in patients – to clinical parameters. Results Despite highly significant differences of T2* time of the globus pallidus (20 vs 39 ms, p < 0.001), perfusion values of this nucleus were nearly identical in both groups (32 ± 3.3 vs 31 ± 4.0 ml/min/100 g) as well as in total brain gray matter (both 62 ± 6.7 resp. ±10.3 ml/min/100 g), putamen (41 ± 5.4 vs 40 ± 6.1 ml/min/100 g), in selected cortical regions, and the cerebellum. Correlations between perfusion and T2* time to clinical data did not reach significance ( p > 0.05). Conclusion The absence of any obvious deviations of perfusion in the group of patients during a resting condition does not support the view that (non-functional) vascular pathology is a major pathogenic factor in pantothenate kinase-associated neurodegeneration in the younger age group. The findings underline the value of the arterial spin technique to measure cerebral blood flow in areas of disturbed susceptibility.
Reimbursement After Congenital Heart Surgery in Germany: Impact of Early Postoperative Extubation
Authors: Murin Peter , Weixler Viktoria , Cho Mi-Young , Vadiunec Valentin , Miera Oliver , Sinzobahamvya Nicodème , Photiadis Joachim 
Published: August 2020

Background: Duration of mechanical ventilation is an important variable used by German Diagnosis-Related Groups (G-DRG) system to establish cost weight values for reimbursement after congenital heart surgery. Infants are commonly ventilated after open heart surgery. As of year 2015, we strived to achieve early postoperative extubation. This work studies how this approach impacted reimbursement after infant open heart surgery. Methods: Data of infants who underwent surgery on cardiopulmonary bypass (CPB) from 2014 to 2018 were reviewed. Successful early extubation was defined as end of mechanical ventilation within 24 hours postoperatively, without reintubation at a later point. Mean cost weight values (case mix index [CMI]) of achieved DRGs were used for estimation of reimbursement. Evolutions over years of early extubation and of reimbursement were compared. Results: A total of 521 infants underwent operations on CPB. Of these, 161 (31%) procedures were of higher risk Society of Thoracic Surgery and the European Association for Cardio-Thoracic Surgery (STAT) categories 3 and 4. Early extubation was achieved in 205 (39%) patients. The rate increased from 14% (year 2014) to 57% (year 2018). Case mix index amounted to 8.87 ± 7.00 after early extubation, and 12.37 ± 7.85 after late extubation: P value <.0001. It was 8.77 ± 6.09 after early extubation in patients undergoing lower risk STAT categories 1 and 2 operations, and 8.09 ± 2.95 when categories 3 and 4 procedures were performed ( P = .18). An overall 14.4% decrease in hospital reimbursement per patient was observed. Conclusion: Early extubation could be progressively obtained in the majority of infants. This resulted in lower reimbursement. Surgical complexity was disregarded. The current G-DRG system appears to favor longer mechanical ventilation durations after infant open heart surgery.
Aortic Valve Intervention During Aortic Root Surgery in Children: A Systematic Review
Authors: Rodriguez Maria , Malvea Anahita , McNally Dayre , Bijelic Vid , Guo Ming , Momoli Franco , Boodhwani Munir 
Published: August 2020

Background: Pediatric aortic root dilatation is a life-threatening condition that lacks guidelines for surgical management. We aimed to analyze the data on aortic valve interventions during root surgery to guide decision-making. Methods: A search was performed of MEDLINE, Embase, CENTRAL, ClinicalTrials.gov , and WHO ICTRP. Citations were screened in duplicate and independently to identify randomized controlled trials, cohorts, and case series involving populations aged 0 to 18 years, who received valve-sparing and valve-replacing aortic root surgeries between 1999 and 2019. Outcomes considered included mortality (perioperative, one year, five year), reintervention rates. Results: After duplicate removal, 689 citations were screened through abstract and full text review, identifying five eligible studies. All five were observational studies evaluating valve-sparing procedures. There were 81 patients with a mean study age range of 9.9 to 13.9 years. Both reimplantation (74%) and remodeling (26%) subtypes were done. Range of mean duration of follow-up was 1.2 to 4.4 years. There was no mortality reported until the one-year follow-up period. The long-term mortality rate was calculated as 0.02 per patient-year (95% CI: 0.01-0.05). The long-term reintervention rate was 0.08 per patient-year (95% CI: 0.05-0.13). Conclusions: There is limited experience on aortic valve intervention during aortic root surgery in children. Single-arm studies on valve-sparing surgeries show excellent survival up to one year. Mortality and reintervention rates increase in the longer term. The small sample size and lack of controlled studies do not allow for direct comparisons between procedure types.
High Prevalence of Superior Labral Anterior-Posterior Tears Associated With Acute Acromioclavicular Joint Separation of All Injury Grades
Authors: Shah Sarav S. , Ferkel Eric , Mithoefer Kai 
Published: August 2020

Background: Despite the relatively high number of cases of acromioclavicular joint (AC) separation in the athletic population, optimal clinical outcomes are not achieved in every case. Limited data exist regarding the prevalence of intra-articular glenohumeral pathologies (IAPs) associated with acute AC separation of all injury grades. Purpose: To determine the prevalence of IAPs associated with AC separation, regardless of severity. Study Design: Case series; Level of evidence, 4. Methods: A total of 62 patients (mean age, 37.6 years) with acute AC separation were included in this study; 41 were nonoverhead recreational athletes. All patients underwent magnetic resonance arthrography (MRA) to evaluate for IAPs. Arthroscopic data from patients undergoing surgical treatment were correlated with MRA results. Results: Patients sustained acute AC separation of Rockwood grade 1 (16.1%), grade 2 (46.8%), grade 3 (25.8%), and grade 4 (11.3%). A concomitant IAP was present in 48 of 62 (77.4%) patients and included superior labral anterior-posterior tears (72.6%), anterior labral tears (24.2%), posterior labral tears (4.8%), supraspinatus tears (3.2%), and inferior glenohumeral ligament ruptures (1.6%). There were 18 (29.0%) patients who had a concomitant pathology in >1 intra-articular structure (combined IAPs). Additionally, 71.8% of patients with grade 1 and 2 AC separation had associated IAPs, and 23.1% had combined IAPs. Furthermore, in patients younger than 40 years, 64.0% of those with grade 1 to 3 AC separation demonstrated associated labral pathologies. There was no difference when comparing age or severity of AC separation and the prevalence of concomitant labral tears ( P = .36 and .22, respectively). Conclusion: There was a high prevalence of IAPs among patients undergoing MRA after AC separation. While an IAP has been described in association with high-grade AC separation previously, the high prevalence of IAPs in low-grade separation in our study was unexpected and suggests that a thorough evaluation and clinical follow-up for patients with all grades of AC separation may be beneficial.
Sailing the sea of open access: celestial navigation or dead reckoning?
Authors: Murphy Kevin P. , Johnson Aaron B. 
Published: August 2020

AbstractThe Open Access movement has gathered significant momentum over the last couple of years. This has been instigated largely by cOAlition S and those funders which support its aims. Is ‘Read and Publish’ the way forward? Will it work for all publishers? All authors? All subscribers? All readers? This article looks at the history of OA and updates a similar piece from 2013. A detailed glossary of terms is given at the end of the article.
Low-grade chronic inflammation is attenuated by exercise training in obese adults through down-regulation of ASC gene in peripheral blood: a pilot study
Authors: Barrón-Cabrera Elisa , González-Becerra Karina , Rosales-Chávez Gustavo , Mora-Jiménez Alondra , Hernández-Cañaveral Iván , Martínez-López Erika 
Published: August 2020

Abstract
Background
Obesity is characterized by low-grade chronic inflammation and an excess of adipose tissue. The ASC gene encodes a protein that is part of the NLRP3 inflammasome, a cytosolic multiprotein complex that is associated with inflammation and metabolic alterations. To our knowledge, there is no evidence regarding ASC gene activity in obese adults in response to lifestyle modifications.

Purpose
To evaluate the effect of hypocaloric diet and moderate-intensity structured exercise intervention on ASC gene expression and inflammatory markers in obese adults.

Methods
Thirty-seven obese individuals aged 25 to 50 years were randomized to the hypocaloric diet exercise group or hypocaloric diet group. The participants underwent a 4-month follow-up. Electrical bioimpedance was used for body composition analysis. Biochemical data were analyzed by dry chemistry and insulin levels by ELISA. ASC gene expression from peripheral blood was performed using real-time PCR. Dietary data was collected through questionnaires and analyzed using the Nutritionist Pro™ software. Quantification of cytokines was conducted using Bio-Plex Pro™ Human cytokine. The Astrand-Ryhming test was used to estimate the maximum oxygen volume and design the moderate-intensity structured exercise program ~ 75% heart rate (HR)

Results
After the intervention, both study groups significantly improved body composition (decreased weight, fat mass, waist circumference and abdominal obesity, p < 0.05). Besides, the diet-exercise group significantly decreased ASC mRNA expression, MCP-1, and MIP-1β inflammatory cytokines compared to the diet group (p < 0.05). While in the diet group, MCP-1 and IL-8 exhibited significantly decreased levels (p < 0.05). In the diet-exercise group, a positive correlation between the atherogenic index and waist circumference was found (r = 0.822, p = 0.011), and a negative correlation was observed between the delta of ASC mRNA expression and IL-10 levels at the end of the intervention (r = − 0.627, p = 0.019).

Conclusion
Low-grade chronic inflammation was attenuated through individualized exercise prescription and our findings highlight the role of the ASC gene in the inflammation of obese adults.

Trial registration
ClinicalTrials.gov, number NCT04315376. Registered 20 March 2020—retrospectively registered
Comparison of the tolerability and efficacy of intra-rectal lidocaine gel with peri-prostatic nerve block as anaesthetic techniques for prostate biopsy
Authors: Tolani Musliu Adetola , Ahmed Muhammed , Lawal Ahmad Tijjani , Fidelis Lovely , Sudi Abdullahi , Hamza Babatunde Kolapo , Awaisu Mudi , Nasir Oyelowo , Bello Ahmad , Maitama Hussaini Yusuf 
Published: August 2020

Abstract
Background
Prostate biopsy is a painful procedure. However, over the years, varied opinions exist among urologists about the methods of achieving optimal pain relief for the procedure. The purpose of this study was to compare the tolerability of administration and the efficacy of intra-rectal lidocaine gel with peri-prostatic nerve block for this procedure.

Methods
From June 2016 to June 2017, 110 patients who met the study criteria were randomized to receive either intra-rectal lidocaine gel (Group 1) or an apical peri-prostatic nerve block (Group 2) for prostate biopsy. Their level of pain perception during the anaesthesia administration and the prostate biopsy was assessed using the Numeric Rating Scale. Other biopsy-related complications and patient satisfaction were also evaluated. Grouped data were compared using student t test and Chi-square with p < 0.05 considered significant.

Results
The pain score during the administration of anaesthesia was 1.6 ± 1.9 and 3.7 ± 2.1 for the intra-rectal lidocaine gel and peri-prostatic nerve block groups, respectively (p = 0.001). However, during the prostate biopsy, the pain score was 6.8 ± 2.2 and 2.9 ± 1.9 for the intra-rectal lidocaine gel and peri-prostatic nerve block groups, respectively (p = 0.001). There was a significantly lower rate of satisfaction (45.3% versus 86.8%, p = 0.001) in the lidocaine gel group.

Conclusions
Although intra-rectal lidocaine gel administration is better tolerated by patients, a peri-prostatic nerve block is more effective and provides better patient satisfaction than intra-rectal lidocaine gel when used as anaesthesia for prostate biopsy.