bluuebunny/crossref_metadata_2025_split huggingface dataset:
The older the better: a fourth-order adaptive network model for reward-driven choices of emotion regulation strategies over time
Authors: Ullah Nimat , Treur Jan 
Published: June 2020

AbstractThe choice of which emotion regulation strategy to use changes depending on context, which within Psychology is referred to as ‘flexibility’. Besides that, choices of emotion regulation strategies are prone to various other factors, ranging from culture to gender, expectations of their effect, age, etc. This paper considers the phenomenon where choices of emotion regulation strategies change adaptively with age. In addition, the choices within specific age frames are driven by some kind of reward that affects in an adaptive manner the learning of a specific emotion regulation strategy. These adaptive phenomena involve plasticity or metaplasticity of different orders. They have been modeled by a fourth-order adaptive mental network model where the choice of emotion regulation strategies is motivated by reward prediction, and different age phases have their own adaptive influences. Simulation results are discussed for evaluation of the adaptive network model. The fourth-order adaptive network model presented here extends a second-order adaptive network model previously addressed in a paper at the conference COMPLEX NETWORKS 2019.
The Gendered Religious Response to State Action on the Coronavirus Pandemic
Authors: Smothers Hannah , Burge Ryan , Djupe Paul 
Published: June 2020

AbstractState action to curtail the spread of the coronavirus has meant advising, and sometimes mandating, houses of worship to close to in-person worship. While mostly cooperative, the religious response has been varied and has exposed a hardened, defiant core. Informed by gendered religious worldviews, religious defiance is led by men and disproportionately supported by men. In this article, we document the extent of the defiance as of late March 2020 with our survey data and then investigate how gendered religious worldviews serve to track men to public roles and women to private ones. We attempt to confirm the nature of these effects with a gendered nationalism item and parallel gender gaps in political participation.
Ventilation and Expansion of Intermediate and Deep Waters in the Southeast Pacific During the Last Termination
Authors: Haddam N. A. , Michel E. , Siani G. , Licari L. , Dewilde F. 
Published: June 2020

AbstractWe investigate the geometry and ventilation of the water masses within bathyal depths (~1,500 to ~2,500 m) of the Southeast Pacific (SEP), inferring the lower depth limit variations of the Antarctic Intermediate Water (AAIW) since ~22 kyr cal. BP. We use three cores collected at the upper limit of the Pacific deep waters, between 41°S and 49°S, and one core at a greater depth within this same water mass, at 46°S. The benthic foraminiferal assemblages and carbon and oxygen isotopes are used to show strong linkages between the timing of the deglacial Southern Ocean upwelling events and changes in the vertical extension and ventilation of the AAIW. In accordance with local/sublocal oxygen reconstructions, we propose at least three states of ventilation‐AAIW vertical extension: (i) the late glacial and the Antarctic Cold Reversal (ACR): AAIW depth‐limit shoals, as its formation zone moves northward; (ii) the deglaciation (excluding the ACR): the [O2] enrichment of the AAIW and the dominance of benthic species Trifarina angulosa indicate ventilated AAIW, along with a deepening of its lower limit; and (iii) the Holocene: enhanced influence of the Pacific deep water at bathyal depths (1,500–2,500 m) in the SEP north of ~46°S and the circumpolar deep water south of ~46°S.
Antarctic Circumpolar Current Dynamics at the Pacific Entrance to the Drake Passage Over the Past 1.3 Million Years
Authors: Toyos María H. , Lamy Frank , Lange Carina B. , Lembke‐Jene Lester , Saavedra‐Pellitero Mariem , Esper Oliver , Arz Helge W. 
Published: June 2020

AbstractThe Antarctic Circumpolar Current (ACC) is the world's largest current system connecting all three major basins of the global ocean. Our knowledge of glacial‐interglacial changes in ACC dynamics in the southeast Pacific is not well constrained and presently only based on reconstructions covering the last glacial cycle. Here we use a combination of mean sortable silt grain size of the terrigenous sediment fraction (10–63 μm,
) and X‐ray fluorescence scanner‐derived Zr/Rb ratios as flow strength proxies to examine ACC variations at the Pacific entrance to the Drake Passage (DP) in the vicinity of the Subantarctic Front. Our results indicate that at the DP entrance, ACC strength varied by ~6–16% on glacial‐interglacial time scales, yielding higher current speeds during interglacial times and reduced current speeds during glacials. We provide evidence that previous observations of a reduction in DP throughflow during the last glacial period are part of a consistent pattern extending for at least the last 1.3 Ma. The orbital‐scale cyclicity follows well‐known global climate changes from prevailing ca. 41‐kyr cycles in the early part of the record (1.3 Ma to 850 ka; marine isotope stage 21) across the mid‐Pleistocene transition into the middle and late Pleistocene 100‐kyr world. A comparison to a bottom water flow record from the deep western boundary current off New Zealand (Ocean Drilling Program Site 1123) reveals anti‐phased changes between the two sites. The enhanced supply of deep water along the DP and into the Atlantic Ocean during interglacials corresponds to a weakened flow of the SW Pacific deep western boundary current.
Great Basin Paleoclimate and Aridity Linked to Arctic Warming and Tropical Pacific Sea Surface Temperatures
Authors: Lachniet Matthew S. , Asmerom Yemane , Polyak Victor , Denniston Rhawn 
Published: June 2020

AbstractThe arid southwestern United States is susceptible to sustained droughts that impact water resources and economic activity for millions of residents. Previous work has not systematically investigated the structure, timing, and possible forcings of Holocene Great Basin sub‐orbital hydroclimate changes, impeding our ability to understand the potential future controls on Southwestern aridity. The objective of this paper is to constrain the potential forcings on Holocene aridity and temperature, via comparison of new high‐resolution speleothem data, an Aridity Index synthesizing hydroclimate records, and linkages of Southwestern paleoclimate to other regions. The high‐resolution data from Leviathan Cave provide a paleoclimate record since 13,400 yr ago: A cool Younger Dryas was followed by two pronounced Middle Holocene aridity intervals between 9,850 and 5,310 yr B2k characterized by low growth rates and high δ18O and δ13C values. Subsequently, stalagmite δ18O values show near‐modern levels for the last four millennia during which time growth rates were high and δ13C values were low in response to wetter conditions. The regional Aridity Index documents that Middle Holocene drying coincided with a warm Arctic and decreased sea ice extent, a warm western tropical Pacific, and a large sea surface temperature gradient across the tropical Pacific, all of which likely responded to northern hemisphere summer insolation forcing. Our data suggest that extreme Middle Holocene aridity is more severe than the short medieval droughts evident in the tree ring record, and such extreme aridity may represent a worst‐case analog for future climate.
Tectono‐Stratigraphic and Thermal Evolution of the Western Betic Flysch: Implications for the Geodynamics of South Iberian Margin and Alboran Domain
Authors: Daudet Maxime , Mouthereau Frédéric , Brichau Stéphanie , Crespo‐Blanc Ana , Gautheron Cécile , Angrand Paul 
Published: June 2020

AbstractThe Betic‐Rif orogen is a key region to understand the evolution of the plate boundary between Africa and Iberia/Europe. This study focuses on the Flysch Complex, which is considered the sedimentary cover of a domain originally positioned between the Iberian and Alboran margins. Based on stratigraphic and depositional evolution constraints, evidence for salt tectonics, combined with new apatite fission‐tracks (AFT) and (U‐Th‐Sm)/He ages from the Flysch Complex and the Subbetic Zone, we propose a geodynamic interpretation for the formation of the Betic Cordillera, accounting for moderate N‐directed transport of the Flysch Complex and synchronous exhumation between External and Internal Zones of the Betic. Early contraction between Africa and Iberia/Europe is reflected in the Cretaceous Flysch basin by a prolonged period of residence in the partial annealing zone for AFT and onset of foreland subsidence at 50 Ma. This stage lasted until the Early to Middle Miocene (20–15 Ma), marked by the rapid succession, in less than 5 Ma, of the deposition of Cenozoic flysch and their rapid exhumation. This event is interpreted to reflect the W‐directed retreating mantle delamination between Africa and Iberia margins at the origin of the collapse of the proto‐Betic orogenic domain and formation of the Alboran domain.
Active Extension in a Foreland Trapped Between Two Contractional Chains: The South Apulia Fault System (SAFS)
Authors: Maesano F. E. , Volpi V. , Civile D. , Basili R. , Conti A. , Tiberti M. M. , Accettella D. , Conte R. , Zgur F. , Rossi G. 
Published: June 2020

AbstractThe response of continental forelands to subduction and collision is a widely investigated topic in geodynamics. The deformation occurring within a foreland shared by two opposite‐verging chains, however, is uncommon and poorly understood. The Apulia Swell in the southern end of the Adria microplate (Africa‐Europe plate boundary, central Mediterranean Sea) represents one of these cases, as it is the common foreland of the SW verging Albanides‐Hellenides and the NE verging Southern Apennines merging into the SSE verging Calabrian Arc. We investigated the internal deformation of the Apulia Swell using multiscale geophysical data: multichannel seismic profiles recording up to 12‐s two‐way time (TWT) for a consistent image of the upper crust; high‐resolution multichannel seismic profiles, high‐resolution multibeam bathymetry, and CHIRP profiles acquired by R/V OGS Explora to constrain the Quaternary geological record. The results of our analyses characterize the geometry of the South Apulia Fault System (SAFS), a 100‐km‐long and 12‐km‐wide structure attesting an extensional (and possibly transtensional) response of the foreland to the two contractional fronts. The SAFS consists of two NW‐SE right‐stepping master faults and several secondary structures. The SAFS activity spans from the Early Pleistocene through the Holocene, as testified by the bathymetric and high‐resolution seismic data, with long‐term slip rates in the range of 0.2–0.4 mm/yr. Considering the position within an area with few or none other active faults in the surroundings, the dimension, and the activity rates, the SAFS can be a candidate causative fault of the 20 February 1743, M 6.7, earthquake.
Gap junction-mediated cell-to-cell communication in oral development and oral diseases: a concise review of research progress
Authors: Liu Wenjing , Cui Yujia , Wei Jieya , Sun Jianxun , Zheng Liwei , Xie Jing 
Published: June 2020

AbstractHomoeostasis depends on the close connection and intimate molecular exchange between extracellular, intracellular and intercellular networks. Intercellular communication is largely mediated by gap junctions (GJs), a type of specialized membrane contact composed of variable number of channels that enable direct communication between cells by allowing small molecules to pass directly into the cytoplasm of neighbouring cells. Although considerable evidence indicates that gap junctions contribute to the functions of many organs, such as the bone, intestine, kidney, heart, brain and nerve, less is known about their role in oral development and disease. In this review, the current progress in understanding the background of connexins and the functions of gap junctions in oral development and diseases is discussed. The homoeostasis of tooth and periodontal tissues, normal tooth and maxillofacial development, saliva secretion and the integrity of the oral mucosa depend on the proper function of gap junctions. Knowledge of this pattern of cell–cell communication is required for a better understanding of oral diseases. With the ever-increasing understanding of connexins in oral diseases, therapeutic strategies could be developed to target these membrane channels in various oral diseases and maxillofacial dysplasia.
Histone chaperone FACT is essential to overcome replication stress in mammalian cells
Authors: Prendergast Laura , Hong Erin , Safina Alfiya , Poe Dante , Gurova Katerina 
Published: June 2020

AbstractThe histone chaperone FACT is upregulated during mammary tumorigenesis and necessary for the viability and growth of breast tumor cells. We established that only proliferating tumor cells are sensitive to FACT knockdown, suggesting that FACT functions during DNA replication in tumor cells but not in normal cells. We hypothesized that the basal level of replication stress defines the FACT dependence of cells. Using genetic and chemical tools, we demonstrated that FACT is needed to overcome replication stress. In the absence of FACT during replication stress, the MCM2-7 helicase dissociates from chromatin, resulting in the absence of ssDNA accumulation, RPA binding, and activation of the ATR/CHK1 checkpoint response. Without this response, stalled replication forks are not stabilized, and new origin firing cannot be prevented, leading to the accumulation of DNA damage and cell death. Thus, we propose a novel role for FACT as a factor preventing helicase dissociation from chromatin during replication stress.
Overview of lethal human coronaviruses
Authors: Chen Bin , Tian Er-Kang , He Bin , Tian Lejin , Han Ruiying , Wang Shuangwen , Xiang Qianrong , Zhang Shu , El Arnaout Toufic , Cheng Wei 
Published: June 2020

AbstractCoronavirus infections of multiple origins have spread to date worldwide, causing severe respiratory diseases. Seven coronaviruses that infect humans have been identified: HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1, SARS-CoV, MERS-CoV, and SARS-CoV-2. Among them, SARS-CoV and MERS-CoV caused outbreaks in 2002 and 2012, respectively. SARS-CoV-2 (COVID-19) is the most recently discovered. It has created a severe worldwide outbreak beginning in late 2019, leading to date to over 4 million cases globally. Viruses are genetically simple, yet highly diverse. However, the recent outbreaks of SARS-CoV and MERS-CoV, and the ongoing outbreak of SARS-CoV-2, indicate that there remains a long way to go to identify and develop specific therapeutic treatments. Only after gaining a better understanding of their pathogenic mechanisms can we minimize viral pandemics. This paper mainly focuses on SARS-CoV, MERS-CoV, and SARS-CoV-2. Here, recent studies are summarized and reviewed, with a focus on virus–host interactions, vaccine-based and drug-targeted therapies, and the development of new approaches for clinical diagnosis and treatment.
Deep learning in mental health outcome research: a scoping review
Authors: Su Chang , Xu Zhenxing , Pathak Jyotishman , Wang Fei 
Published: June 2020

AbstractMental illnesses, such as depression, are highly prevalent and have been shown to impact an individual’s physical health. Recently, artificial intelligence (AI) methods have been introduced to assist mental health providers, including psychiatrists and psychologists, for decision-making based on patients’ historical data (e.g., medical records, behavioral data, social media usage, etc.). Deep learning (DL), as one of the most recent generation of AI technologies, has demonstrated superior performance in many real-world applications ranging from computer vision to healthcare. The goal of this study is to review existing research on applications of DL algorithms in mental health outcome research. Specifically, we first briefly overview the state-of-the-art DL techniques. Then we review the literature relevant to DL applications in mental health outcomes. According to the application scenarios, we categorize these relevant articles into four groups: diagnosis and prognosis based on clinical data, analysis of genetics and genomics data for understanding mental health conditions, vocal and visual expression data analysis for disease detection, and estimation of risk of mental illness using social media data. Finally, we discuss challenges in using DL algorithms to improve our understanding of mental health conditions and suggest several promising directions for their applications in improving mental health diagnosis and treatment.
Circular RNA circZNF566 promotes hepatocellular carcinoma progression by sponging miR-4738-3p and regulating TDO2 expression
Authors: Li Shanbao , Weng Junyong , Song Fangbin , Li Lei , Xiao Chao , Yang Weiqiang , Xu Junming 
Published: June 2020

AbstractAs a recently discovered noncoding RNA, circular RNAs (circRNAs) have been identified to play key roles in cancer biology; however, the detailed functions and mechanisms of circRNAs in hepatocellular carcinoma (HCC) remain largely unclarified. RNA-seq analysis was used to screen the expression profiles of circRNAs in HCC. CircZNF566 expression in HCC tissues and cell lines was detected by qRT-PCR. In vitro CCK-8, colony formation, wound healing, transwell migration, and invasion assays and in vivo tumorigenesis and metastasis assays were conducted to determine the functions of circZNF566. Luciferase reporter, RNA immunoprecipitation (RIP) and RNA pull-down assays were also performed to confirm the relationship between circZNF566 and miR-4738-3p. Bioinformatics analysis and luciferase reporter assays were employed to determine whether miR-4738-3p regulates tryptophan 2,3-dioxygenase (TDO2) expression. Finally, immunohistochemistry (IHC) was used to detect the level of TDO2 and determine its prognostic value. CircZNF566 was significantly upregulated in HCC tissues and cell lines. High circZNF566 expression in HCC tissues was positively correlated with clinicopathological features and poor prognosis. Functionally, in vitro experiments showed that circZNF566 promoted HCC cell migration, invasion, and proliferation, whereas in vivo experiments showed that circZNF566 promoted tumorigenesis and metastasis. Mechanistically, circZNF566 acted as a miR-4738-3p sponge to relieve the repressive effect of miR-4738-3p on its target TDO2. In addition, miR-4738-3p suppressed HCC cell migration, invasion, and proliferation, while TDO2 was positively correlated with pathological features and poor prognosis and promoted cell migration, invasion, and proliferation in HCC. CircZNF566 is a novel tumor promoter in HCC and functions through the circZNF566/ miR-4738-3p /TDO2 axis; in addition, circZNF566 may serve as a novel diagnostic marker, prognostic indicator, and target for the treatment of HCC.
Intracellular virus sensor MDA5 exacerbates vitiligo by inducing the secretion of chemokines in keratinocytes under virus invasion
Authors: Zhuang Tongtian , Yi Xiuli , Chen Jianru , Kang Pan , Chen Xuguang , Chen Jiaxi , Cui Tingting , Chang Yuqian , Ye Zhubiao , Ni Qingrong , Wang Yinghan , Du Pengran , Li Baizhang , Liu Ling , Jian Zhe , Li Kai , Gao Tianwen , Li Shuli , Li Chunying 
Published: June 2020

AbstractVitiligo is a disfiguring disease featuring chemokines-mediated cutaneous infiltration of autoreactive CD8+ T cells that kill melanocytes. Copious studies have indicated that virus invasion participates in the pathogenesis of vitiligo. IFIH1, encoding MDA5 which is an intracellular virus sensor, has been identified as a vitiligo susceptibility gene. However, the specific role of MDA5 in melanocyte death under virus invasion is not clear. In this study, we first showed that the expression of anti-CMV IgM and MDA5 was higher in vitiligo patients than healthy controls. Then, by using Poly(I:C) to imitate virus invasion, we clarified that virus invasion significantly activated MDA5 and further potentiated the keratinocyte-derived CXCL10 and CXCL16 which are the two vital chemokines for the cutaneous infiltration of CD8+ T cells in vitiligo. More importantly, IFN-β mediated by the MDA5-MAVS-NF-κB/IRF3 signaling pathway orchestrated the secretion of CXCL10 via the JAK1-STAT1 pathway and MDA5-meidiated IRF3 transcriptionally induced the production of CXCL16 in keratinocytes under virus invasion. In summary, our results demonstrate that MDA5 signaling orchestrates the aberrant skin immunity engaging in melanocyte death via mediating CXCL10 and CXCL16 secretion, which supports MDA5 as a potential therapeutic target for vitiligo under virus invasion.
MAPK-dependent hormonal signaling plasticity contributes to overcoming Bacillus thuringiensis toxin action in an insect host
Authors: Guo Zhaojiang , Kang Shi , Sun Dan , Gong Lijun , Zhou Junlei , Qin Jianying , Guo Le , Zhu Liuhong , Bai Yang , Ye Fan , Wu Qingjun , Wang Shaoli , Crickmore Neil , Zhou Xuguo , Zhang Youjun 
Published: June 2020

AbstractThe arms race between entomopathogenic bacteria and their insect hosts is an excellent model for decoding the intricate coevolutionary processes of host-pathogen interaction. Here, we demonstrate that the MAPK signaling pathway is a general switch to trans-regulate differential expression of aminopeptidase N and other midgut genes in an insect host, diamondback moth (Plutella xylostella), thereby countering the virulence effect of Bacillus thuringiensis (Bt) toxins. Moreover, the MAPK cascade is activated and fine-tuned by the crosstalk between two major insect hormones, 20-hydroxyecdysone (20E) and juvenile hormone (JH) to elicit an important physiological response (i.e. Bt resistance) without incurring the significant fitness costs often associated with pathogen resistance. Hormones are well known to orchestrate physiological trade-offs in a wide variety of organisms, and our work decodes a hitherto undescribed function of these classic hormones and suggests that hormonal signaling plasticity is a general cross-kingdom strategy to fend off pathogens.
Sub-nanowatt microfluidic single-cell calorimetry
Authors: Hong Sahngki , Dechaumphai Edward , Green Courtney R. , Lal Ratneshwar , Murphy Anne N. , Metallo Christian M. , Chen Renkun 
Published: June 2020

AbstractNon-invasive and label-free calorimetry could become a disruptive technique to study single cell metabolic heat production without altering the cell behavior, but it is currently limited by insufficient sensitivity. Here, we demonstrate microfluidic single-cell calorimetry with 0.2-nW sensitivity, representing more than ten-fold enhancement over previous record, which is enabled by (i) a low-noise thermometry platform with ultralow long-term (10-h) temperature noise (80 μK) and (ii) a microfluidic channel-in-vacuum design allowing cell flow and nutrient delivery while maintaining a low thermal conductance of 2.5 μW K−1. Using Tetrahymena thermophila as an example, we demonstrate on-chip single-cell calorimetry measurement with metabolic heat rates ranging from 1 to 4 nW, which are found to correlate well with the cell size. Finally, we perform real-time monitoring of metabolic rate stimulation by introducing a mitochondrial uncoupling agent to the microchannel, enabling determination of the spare respiratory capacity of the cells.