bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manajemen Pembelajaran Musik Siswa MIS (Manado Internasional School) secara virtual di Era Kenormalan Baru
Authors: Kaunang Meyny S. C. 
Published: September 2020

IntisariPenelitian ini di lakukan pada sekolah MIS (Manado Internasional School), yang memiliki latarbelakang budaya yang berbeda sehing-ga menjadikan pembelajaran dalam kelas menjadi saling mengisi. Manajemen pembelajaran yang diterapkan pada masa pandemik Covid-19 lebih pada bentuk virtual, atau jaga jarak apabila ber-tatap muka. Manajemen yang dilaksanakan pada pembelajaran ini bertujuan agar siswa lebih cepat dalam menerima pembelajaran musik. Metode yang digunakan dalam penelitian ini adalah metode diskriptif-kualitatif. Pengumpulan data menggunakan trigulasi. Ob-servasi dilakukan sesuai dengan protokol kesehatan, wawancara dilakukan dengan jaga jarak dan secara virtual, melalui aplikasi Zoom Cloud Meetings atau video call. Hasil penelitian ini menun-jukkan bahwa manajemen pembelajaran musik di MIS dalam masa pandemik Covid-19 atau Era Kenormalan Baru dilaksanakan dalam bentuk virtual. Media pembelajaran yang digunakan untuk penun-jang siswa dalam berlatih mandiri adalah media youtube. Hasil pembelajaran ini diketahui lebih efektif dalam hal melatih kepekaan siswa bisa, dan mereka pun dapat dikontrol secara ber-ulang-ulang.Kata kunci: pembelajaran musik, permbelajaran virtual, era kenormalan baru, manado internasional school AbstractThis research was conducted at the MIS (Manado International School) school, which has different cultural backgrounds so that learning in the classroom is complementary. Learning management that was applied during the Covid-19 pandemic was more in a vir-tual form, or maintaining a distance when face to face. Manage-ment carried out in this learning aims to make students accept music learning more quickly. The method used in this research is descriptive-qualitative method. Data collection using trigulation. Ob-servers were carried out in accordance with health protocols, interviews were conducted in a distance and virtually, via the Zoom Cloud Meetings application or video call. The results of this study indicate that the management of music learning in MIS during the Covid-19 pandemic or the New Normal Era was implemented in vir-tual form. The learning media used to support students in prac-ticing independently is the youtube media. The learning outcomes are known to be more effective in terms of training students' sensi-tivity, and they can be controlled repeatedly.Keywords: music learning, virtual learning, new normal era, manado international school
DIAGNÓSTICO DE ENFERMAGEM TENSÃO DO PAPEL DE CUIDADOR EM FAMILIARES DE PESSOAS COM FERIDAS CRÔNICAS
Authors: Da Silva Kezia Juliana , Lopes Dias Julliany , Gomes da Silva Neto Maurício , Da Silva Oliveira Araújo Henrique , Martins Bastos Amanda , Andrade Martins Marlene , Rodrigues Alves Montefusco Selma , Pereira Ângela Lima 
Published: September 2020

O cuidado da pessoa com ferida crônica é complexo, e sob responsabilidade da família gera demandas que podem resultar em cansaço e desgaste do cuidador, que é apresentado na NANDA-I como tensão no papel de cuidador. O objetivo foi analisar a ocorrência do diagnóstico de enfermagem (DE) tensão do papel de cuidador em familiares de pessoas com feridas crônicas. Trata-se de um estudo descritivo exploratório, realizado em 2019, por meio de entrevista semiestruturada com pessoas que cuidam de um familiar com ferida crônica em Palmas-Tocantins. Análise de variáveis quantitativas realizada por estatística descritiva, e de variáveis subjetivas por “agrupamento de dados” e “interpretação do agrupamento”. Identificados 6 cuidadores com DE tensão no papel de cuidador, com predomínio do sexo feminino, grau de parentesco de filhos e cônjuges. Os principais fatores relacionados foram: excesso de atividades de cuidado, crise financeira e o prejuízo à saúde. A principal característica definidora foi a falta de tempo para atender às necessidades pessoais. Tensão no papel de cuidador em familiares de pessoas com feridas crônicas gera implicações significativas na saúde e dinâmica de vida dos cuidadores. Assim, tornam-se necessárias políticas de saúde que atendam não apenas a população com ferida crônica, mas também a família.
Palavras-chave: Relações familiares; Diagnóstico de Enfermagem; Ferimentos e lesões.
Comparative gene expression profiling of mouse ovaries upon stimulation with natural equine chorionic gonadotropin (N-eCG) and tethered recombinant-eCG (R-eCG)
Authors: Min kwan-sik , Park Jong-Ju , Lee So-Yun , Byambaragchaa Munkhzaya , Kang Myung-Hwa 
Published: September 2020

Abstract
Background: Equine chorionic gonadotropin (eCG) induces super-ovulation in laboratory animals. Notwithstanding its extensive usage, limited information is available regarding the differences between the in vivo effects of natural eCG (N-eCG) and recombinant eCG (R-eCG). This study aimed to investigate the gene expression profiles of mouse ovaries upon stimulation with N-eCG and R-eCG produced from CHO-suspension (CHO-S) cells. R-eCG gene was constructed and transfected into CHO-S cells and quantified. Subsequently, we determined the metabolic clearance rate (MCR) of N-eCG and R-eCG up to 24 h after intravenous administration through the mice tail vein and identified differentially expressed genes in both ovarian tissues, via quantitative real-time PCR (qRT-PCR) and immunohistochemistry (IHC). Results: R-eCG was markedly expressed initially after transfection and maintained until recovery on day 9. Glycan chains were substantially modified in R-eCG protein produced from CHO-S cells and eliminated through PNGase F treatment. The MCR was slightly lower for R-eCG than for N-eCG, and no significant difference was observed after 60 min. Notwithstanding their low concentrations, R-eCG and N-eCG were detected in the blood at 24h post-injection. Microarray analysis of ovarian tissue revealed that 20 of 12,816 genes assessed therein were significantly up-regulated and 43 genes were down-regulated by >2-fold in the group that received R-eCG (63 [0.49%] differentially regulated genes in total). The microarray results were concurrent with and hence validated by those of RT-PCR, qRT-PCR, and IHC analyses. Conclusions: The present results indicate that R-eCG can be adequately produced through a cell-based expression system through post-translational modification of eCG and can induce ovulation in vivo. These results provide novel insights into the molecular mechanisms underlying the up- or down-regulation of specific ovarian genes and the production of R-eCG with enhanced biological activity in vivo.
Climatology of Medium-Scale Traveling Ionospheric Disturbances (MSTIDs) Observed with GPS Networks in the North African Region
Authors: Oluwadare Temitope Seun , Jakowski Norbert , Valladares Cesar E. , Akala Andrew Oke-Ovie , Abe Oladipo E. , Alizadeh Mahdi M. , Schuh Harald 
Published: September 2020

Abstract
We present for the first time the climatology of medium-scale traveling ionospheric disturbances (MSTIDs) by using Global Positioning System (GPS) receiver networks on geomagnetically quiet days (Kp ≤ 3) over the North African region during 2008-2016. The ionospheric Total Electron Content (TEC) were estimated from the dual-frequency GPS measurements, and the TEC perturbations (dTEC) data were derived from the estimated TEC data. We focused on the TEC perturbations (dTEC) associated MSTIDs and statistically analyzed its characteristics, occurrence rate, diurnal and seasonal behavior as well as the interannual dependence. The results show that MSTID is a local and seasonal dependence. The results also show that MSTIDs predominantly propagates towards the South (equatorward). The daytime and nighttime MSTIDs increase with solar activity, and its event period is (12 ≤ period ≤ 53 mins), while the dominant amplitude is (0.08 ≤ amp ≤ ~1.5 dTECU). The MSTIDs propagation velocity is dominantly higher at the daytime than nighttime. The study also shows that the disturbance occurrence time is more frequent within the hours of (1200 - 1600 LT), and (1000 - 1400 LT) in December solstice at daytime for stations located in the Northwest (NW) and Northeast (NE) part of the African region, respectively. While at the nighttime, the MSTIDs also exhibits variability in disturbance occurrence time around (NW: 2100–0200 LT) and (NE: 1900–0200 LT) in June solstice, but get extended to March equinox during solar maximum (2014). The mean phase velocity in daytime MSTIDs is higher than the nighttime in every season, except during June solstice.
Effectiveness of Interventions on Early Neurodevelopment of Preterm Infants: A Systematic Review and Meta-Analysis
Authors: Aita Marilyn , Clifford-Faugère Gwenaëlle De , Lavallée Andréane , Feeley Nancy , Stremler Robyn , Rioux Emilie , Proulx Marie-Hélène 
Published: September 2020

Abstract
Background : As preterm infants’ neurodevelopment is shaped by NICU-related factors during their hospitalization, it is essential to evaluate which interventions are more beneficial for their neurodevelopment at this specific time. The primary objective of this systematic review and meta-analysis was to evaluate the effectiveness of interventions initiated during NICU hospitalization on preterm infants’ early neurodevelopment during their hospitalization and up to two weeks corrected age (CA). Methods: This systematic review referred to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses [PRISMA] guidelines and was registered in PROSPERO (CRD42017047072). We searched CINAHL, MEDLINE, PubMed, EMBASE (OVID), Cochrane Systematic Reviews, CENTRAL, and Web of Science from 2002 to February 2020. Two independent reviewers performed the study selection, data extraction, assessment of risks of bias and quality of evidence. Results: Findings of 12 studies involving 901 preterm infants were synthesized. We combined three studies in a meta-analysis showing that compared to standard care, NIDCAP intervention is effective in improving preterm infants’ neurobehavioral and neurological development at two weeks CA. We also combined two other studies in a meta-analysis indicating that parental participation did not significantly improve preterm infants’ neurobehavioral development during NICU hospitalization. For all other interventions (i.e., developmental care, sensory stimulation, music and physical therapy), the synthesis of results shows that compared to standard care or other types of comparators, the effectiveness was either controversial or partially effective. Conclusions: The overall quality of evidence was rated low to very low. Future studies are needed to identify interventions that are the most effective in promoting preterm infants’ neurodevelopment during NICU hospitalization or close to term age. Interventions should be appropriately designed to allow comparison with previous studies and a combination of different instruments could provide a more global assessment of preterm infants’ neurodevelopment and thus allow for comparisons across studies. Systematic Review Protocol Registration: Prospero CRD42017047072
Toluidine Staining as a Screening Tool for Soft Tissue Margins of Cancerous Oral Lesions
Authors: ali aeman , Sheikh Abdul Hafeez , Farooqui Waqas Ahmed , Fatima Sara 
Published: September 2020

Abstract
Background:As the world is becoming advanced, the number of diseases also seems to be increasing. Mouth cancer and oral lesions are known as dangerous and fatal diseases. The experimentation is in the process. The problem is not new; it has been the cause of deaths of many patients since many decades. The increase in cancer patients has been recorded up to 43% in the last 8.1 years and it has been observed that most of the cancerous cells are malignant at the time of diagnosis and treatment.It is mandatory for the physician or the dental experts to diagnose oral cancer in the early stage and remove the tumor along with safe margins to decrease the chances of reoccurrence of the disease.The objective of the study is to detect the usefulness of the toulidine blue dye as a cost effective, less time consuming and a user-friendly screening tool for the tumor margins intra-operatively.Methods:Fifty patients with biopsy proven oral squamous cell carcinoma who were advised surgical resection as a treatment plan, independent of the grade and stage of the tumor, by the department of Oral and Maxillofacial surgery of Dow University of Health Sciences were considered to undergo intra-operative toluidine blue dye staining and the results were compared and confirmed by the frozen biopsy section of the same margin.Results:Total fifty patients were participated in this study involving multiple margins. 86% agreement was present between the dye and the biopsy and the sensitivity of the dye appears to be 74% as 20 cases out of 27 showed true positive results yet specificity of the dye remains 100% as all 23 cases displayed true negative results. Conclusion:Toluidine blue dye has demonstrated to be a safe, convenient and time saving method of screening of the margins as it takes less than 5 minutes in its application and result starts to appear in within 3 to 5 minutes. Yet bigger lesions are yet to be focused as they have chances of giving false results. Moreover there is room for research in this aspect as the screening character of this dye is yet to be proved.
A Retrospective Study of Hemodialysis Treated End-stage Renal Disease Patients With Renal Osteodystrophy-associated Fragility Fractures
Authors: Xie Lihua , Hu Xuantao , Li Wenzhao , Ouyang Zhengxiao 
Published: September 2020

Abstract
Background: Nephropathy associated metabolic disorder induces high incidence of fragility fracture in end-stage renal disease (ESRD) patients. As the risk factors and prognosis of fragility fracture in ESRD patients are unclear, more research is needed. This study aimed to evaluate various risk factors for ESRD-related fragility fractures, explore factors affecting the prognosis of patients with such fractures, and provide information for prevention and treatment of renal osteopathy to improve the prognosis of patients.Methods: In this retrospective case-control study, the case notes of 521 ESRD patients who received maintenance dialysis for at least 3 months were examined. Finally, 44 patients diagnosed with fragility fractures were assigned to the fragility fracture (FF) group and 192 patients were included in the control group (CG). Demographic information, underlying diseases, nutritional, bone metabolism, and renal function parameters, along with the number and causes of any deaths, were recorded for multiple statistical analysis.Results: The FF group had increased incidences of essential hypertension and diabetes mellitus and higher serum calcium, corrected calcium, alkaline phosphatase, and hemoglobin levels. Immunoreactive parathyroid hormone (iPTH), total cholesterol (TC), and low density lipoprotein (LDL) levels were higher in the CG.Conclusions: Essential hypertension and diabetes, high serum calcium and alkaline phosphatase levels, and reduced iPTH levels were risk factors for fragility fracture in ESRD patients. Maintaining iPTH and serum TC levels may protect against fragility fractures in them. Fragility fractures may yield poor prognosis and shorter lifespan. The presence of fragility fracture was an independent predictor of all-cause death in ESRD patients.
Development and Validation of an Automated Emergency Department-Based Syndromic Surveillance System for Use at a Mass Gathering Event (2020 Arctic Winter Games, Yukon Canada) During a Global Pandemic: Implications for Lower Resourced and Remote Settings
Authors: Bouchouar Etran , Hetman Benjamin M. , Hanley Brendan 
Published: September 2020

Abstract
Background: Automated syndromic surveillance systems are useful tools for rapidly identifying health risks during times when routine surveillance and follow-up cannot meet the demands of the population. In Yukon, Canada, the Arctic Winter Games were scheduled in March 2020, and were expected to increase the local population beyond the capacity of local public health surveillance. An emergency department-based automated syndromic surveillance system was therefore developed and validated using local hospitalization records for use during the event. Methods: Syndromes of interest were identified in consultation with the local public health authorities. For each syndrome, case definitions were developed using published resources and expert elicitation. Natural language processing algorithms were then written to detect syndromic cases from three different fields (triage notes; chief complaint; discharge diagnosis) using Yukon emergency department case data containing information from 19,082 visits over the period of October 1, 2018 to April 30, 2019. The automatic identification of cases was then manually validated by two raters and results were used to calculate positive predicted values for each syndrome and identify improvements to the detection algorithms. Results: A total of six syndromes were originally identified for the syndromic surveillance system (e.g., Gastrointestinal, Influenza-like-Illness, Mumps, Neurological Infections, Rash, Respiratory), with an additional syndrome added to assist in detecting potential cases of COVID-19. The positive predictive value for the automated detection of each syndrome ranged from 48.8%-89.5% to 62.5%-94.1% after implementing improvements identified during validation. As expected, no records were flagged for COVID-19 from our validation dataset. However, the system was rapidly adapted into an additional surveillance tool for use in the COVID-19 pandemic. Conclusions: Validation is an important step for measuring the accuracy of syndromic surveillance, and ensuring it performs adequately in a local context. Ultimately, the 2020 Arctic Winter Games were cancelled due to the risks associated with mass gatherings during the global pandemic of COVID-19 and could not therefore be tested under a mass gathering scenario. However, the results from our validation study suggest that our surveillance system may be useful for future mass gathering events and proved a timely development for integration into Yukon’s COVID-19 surveillance infrastructure.
Holmium Laser Enucleation of the Prostate With Virtual Basket Mode: Faster and Better Control on Bleeding
Authors: Bozzini Giorgio , Maltagliati Matteo , Besana Umberto , Berti Lorenzo , Calori Alberto , Sighinolfi Maria Chiara , Micali Salvatore , Roche Jean Baptiste , Gozen Ali , Mueller Alexander , Pushkar Dimitry , Liatsikos Evangelos , Boldini Marco , Buizza Carlo , Rocco Bernardo 
Published: September 2020

Abstract
BACKGROUND: To compare clinical intra and early postoperative outcomes between conventional Holmium laser enucleation of the prostate (HoLEP) and Holmium laser enucleation of the prostate with Virtual Basket tool (VB-HoLEP) to treat benign prostatic hyperplasia (BPH).METHODS: This prospective randomized study enrolled consecutive patients with BPH to HoLEP (n = 100) or VB-HoLEP (n =100). We evaluated all patients preoperatively with particular attention to catheterization time, operative time, blood loss, irrigation volume and hospital stay. We evaluated also the patients at 3, 6 and 12 months after surgery with the use of maximum flow rate (Qmax), postvoid residual urine volume (PVR) and International Prostate Symptom Score (IPSS).RESULTS: We didn’t see significant difference in preoperative parameters between patients in each study arm. Compared with HoLEP, VB-HoLEP resulted in less hemoglobin decrease (2.54 vs 1.12 g/dL, P = .003) and had a more rapid operative time (57.33±29.71 vs 42.99±18.51 minutes, P = 0.04). HoLEP and VB-HoLEP had same catheterization time (2.2 vs 1.9 days, P = 0.45), irrigation volume (33.3 vs 31.7 L, P = 0.69), and hospital stay (2.8 vs 2.7 days, P = 0.21). During the follow-up of subsequent 12 months, we didn’t demonstrate a significant difference in IPSS, Qmax, PVR, and QOLS.CONCLUSION: HoLEP and VB-HoLEP both are efficient a safe procedure for relieving lower urinary tract symptoms. VB-HoLEP was statistically superior to HoLEP in blood loss and to allow a faster procedure. However, procedures did not differ significantly in catheterization time, hospital stay, operation time and irrigation volume. No differences were demonstrated in QOLF, IPSS, Qmax and PVR through the post-surgery 12 months of follow-up.TRIAL REGISTRATION: Current Controlled Trials ISRCTN72879639; date of registration: June 25th, 2015. Retrospectively registred.
Humanistic Care in the Intensive Care Unit: A Qualitative Study
Authors: Hasandoost Fateme , Mohammadi Eesa , Khademi Mojgan , Seddighi Mahyar 
Published: September 2020

Abstract
Background: Nurses working in intensive care units do their main part of the job using medical equipment. Scholars have long debated the impact of technology on nursing. Those on the negative side perceive technologies as obtrusive to comprehensive humanistic care. Up to now, there has been little investigation of the nurses' perceptions of this phenomenon. The aim of the study was, therefore, to explore the perceptions of nurses and attendants of humanistic care in the intensive care unit.Methods: The present study was a qualitative conventional content analysis conducted in an intensive care unit in a hospital in Qazvin, Iran, in 2019. Data was collected using unstructured interviews and field notes and then analyzed using the Elo-Kyngäs method in 2008.Results: Continuous and comparative analysis of the data led to the extraction of 4 main themes as follows: 1) Insufficient understanding of nurses and patients’ families of each other's roles, needs, and expectations; 2) The use of personal and situational reasoning rather than ethical principles; 3) Caring stagnation, and 4) Satisfaction with care.Conclusion: The findings of the study indicated that due to lack of equipment, high workloads, and anxieties, nurses and attendants might not be able to understand each other’s roles and expectations. If it is not resolved properly, this situation will end in conflicts and stagnation in healthcare. Patients admitted to an intensive care unit are usually in critical health conditions. However, nurses feel satisfied with the outcome of their jobs when those patients are discharged from the hospital with a stable health condition. Shedding more light on the humanistic care status in intensive care units in Iran, the results of this research can be applied to health professionals and nursing managers.