bluuebunny/crossref_metadata_2025_split huggingface dataset:
Underwater Versus Conventional Endoscopic Mucosal Resection for Colorectal Laterally Spreading Tumors: A Post Hoc Analysis of Efficacy
Authors: Le Quang Dinh , Le Nhan Quang , Quach Duc Trong 
Published: December 2024

ABSTRACTBackground and AimsUnderwater endoscopic mucosal resection (UEMR) has emerged as a promising alternative to conventional endoscopic mucosal resection (CEMR) for the treatment of colorectal laterally spreading tumors (LSTs). This study aimed to compare the efficacy and safety of UEMR and CEMR in managing LSTs measuring 10–30 mm.MethodsA post hoc analysis was performed on 88 patients with 88 colorectal LSTs, who were randomly assigned to two treatment groups: 42 with CEMR and 46 with UEMR. The primary outcome was the rate of R0 resection, defined as the absence of neoplastic cells at the resection margin. The secondary outcomes included en bloc resection rates, procedure times, and postprocedural complications. The data were analyzed via chi‐square tests, t tests, and the Mann–Whitney U test where appropriate.ResultsNo significant difference was found in the R0 resection rate between UEMR and CEMR. However, UEMR achieved a significantly higher en bloc resection rate, particularly for LSTs ranging from 20 to 30 mm (42.9% for CEMR vs. 100% for UEMR; p = 0.009). Additionally, UEMR resulted in a shorter median procedure time (85.0 s for UEMR vs. 207.5 s for CEMR; p < 0.001). There was no significant difference in bleeding complications or the number of clips used between the two groups.ConclusionsCompared with CEMR, UEMR offers a higher en bloc resection rate and a shorter procedure time, particularly for larger lesions, without increasing the risk of complications. UEMR should be considered a preferred option for managing colorectal LSTs, especially those measuring 20–30 mm.
Utility and safety of endoscopic papillary balloon dilation with small‐incision sphincterotomy for small bile duct stones: A randomized controlled trial
Authors: Ishida Yuki , Hisa Takeshi , Matsumoto Ryusuke , Nishiyama Shigeru , Kudo Akiharu , Yamada Takahiro , Osera Shozo , Tomori Akihisa , Fukushima Hideki 
Published: December 2024

AbstractBackgroundEndoscopic sphincterotomy (ES) for bile duct stones (BDS) can cause basket impaction with stone, complicating the procedure. In this study, we evaluated the utility and safety of small incision ES combined with endoscopic papillary balloon dilation (sES + EPBD) (balloon dilated up to the stone size), compared with ES alone for BDS <12 mm.MethodsThe primary endpoint was the frequency of mechanical lithotripsy (ML), indicating the risk of basket impaction with stone; however, the secondary endpoints were procedure time, successful stone removal, and early adverse events.ResultsA total of 100 patients were randomized into the ES and sES + EPBD groups (n = 50 for each). Significantly fewer cases required ML (20.0% vs. 4.0%, p = .028) in the sES + EPBD group. The maximum short‐axis diameter of the stones in all patients requiring ML in the ES group ranged from 8 to 11 mm. The median procedure time was significantly shorter (18.5 min vs. 17 min, p = .047) in the sES + EPBD group. Both groups showed similar frequencies of successful stone removal in one session (88.0% vs. 98.0%, p = .112) and early adverse events (4.0% vs. 2.0%, p = .62).ConclusionIn cases of small BDS, sES + EPBD exhibits a low frequency of ML, which shortens procedure time and prevents basket impaction with stones.
Evolutionary Transitions of DNA Replication Origins Between Archaea and Bacteria
Authors: Saranya S. , Prathiviraj R. , Chellapandi P. 
Published: December 2024

ABSTRACTDNA replication origins play a crucial role in cellular division and are evolutionarily conserved across domains. This study investigated the evolutionary transitions of replication origins between archaea and bacteria by analyzing 2733 bacterial and 257 archaeal genomes. Our findings revealed that certain methanogens and bacteria share phylogenetic proximity, suggesting evolutionary interactions across diverse ecological systems. Evolutionary transitions in replication origins may have occurred between gut methanogens and bacteria, haloarchaea (Halogeometricum borinquense DSM 11551 and Halovivax ruber XH‐70), halobacteria, and sulfur‐reducing archaea. Methanosarcina barkeri (M. barkeri), Methanosaeta thermophila, and Methanococcoides burtonii (M. burtonii) were closely related to respiratory tract bacteria in humans. Methanohalobium evestigatum (M. evestigatum) is strongly linked to the animal gut pathogen Mycoplasma putrefaciens (M. putrefaciens). Several thermophilic hydrogenotrophic methanogens clustered with oral and fish pathogens. Pyrococcus furiosus (P. furiosus) was evolutionarily related to the replication origin of plant pathogens. This study sheds light on the ecological drivers of DNA replication origin evolution and their role in microbial speciation and adaptation. Our findings highlight the influence of mutualistic and parasitic relationships on these evolutionary transitions. It could have significant implications in biotechnology and medicine, such as developing novel antimicrobial strategies and understanding host‐pathogen dynamics.
Anterior cruciate ligament reconstruction with six and eight‐strand hamstring tendon autografts produces adequate graft dimensions and functional outcomes: A systematic review
Authors: Sun Bryan , Lee Boss , Grad Justin , Cohen Dan , Abouali Jihad , Tapasvi Sachin , Maniar Adit , de SA Darren 
Published: December 2024

AbstractPurposeThis study aims to summarize the graft dimensions, failure rates, return‐to‐sport rates and patient‐reported outcome measures (PROMs) following anterior cruciate ligament reconstruction (ACLR) with six or eight‐strand hamstring tendon autografts (6SHG or 8SHG).MethodsThree databases were searched from inception to 12 February 2024. The authors adhered to PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. All clinical studies reporting patient demographics, objective clinical outcomes and PROMs following ACLR with 6SHG or 8SHG were included for data synthesis. PROMs included the International Knee Documentation Committee (IKDC), Lysholm and Tegner scores.ResultsThirteen studies comprising 1103 patients were included (mean age: 30.6 years). The transtibial technique was used in all studies, except one study using anatomic ACLR (n = 38), and one study using transtibial and all‐inside ACLR (n = 41). Eight studies comprising 512 patients used 6SHG, four studies comprising 507 patients 8SHG and two studies comprising 97 patients used either. Mean graft diameters ranged from 8.0 to 9.2 mm (6SHG) and 9.1 to 9.9 mm (8SHG). Mean graft lengths for 49 6SHG patients ranged from 60.0 to 83.3 mm. The failure rate for 817 patients (6SHG or 8SHG) was 4.8% (0.0%–20.0%). The return‐to‐sport rate for 112 patients (6SHG or 8SHG) was 75.9% (69.7%–100.0%). Mean IKDC, Lysholm and Tegner scores for 6SHG or 8SHG were 88.4 (86.1–96.3), 91.7 (90.4–96.5) and 6.9 (6.5–7.3), respectively.ConclusionsBoth 6SHG and 8SHG produced graft diameters <8 mm. Data regarding PROMs suggested good patient satisfaction based on established criteria. Re‐rupture and return‐to‐sport rates were 4.8% and 75.9%, respectively.Level of EvidenceLevel IV.
Deciphering Characteristics of Bacterial Diversity and Potential Function in Acidic Soils of Jiaodong Peninsula, China
Authors: Rong Fangxu , Liu Jing , Hou Guoqin , Wang Guizhen , Li Mingyue , Liu Kai , Wazir Zafran Gul , Liu Hongliang , Liu Aiju , Xu Yuzhi 
Published: December 2024

ABSTRACTSoil acidification globally stressed agricultural production and food security. Jiaodong Peninsula, an important agricultural area of China, is also experiencing a serious soil acidity problem. However, There is limited knowledge regarding the differences of microbial diversity and functions in acidic soils in relation to land uses. Here, bacterial diversity and functions were compared between orchard and farmland soils of the Jiaodong region, in addition to soil progressive acidification. The results demonstrated that compared to farmland soils (pH is 5.36 average), orchard soils with an average pH of 4.70 faced a more serious acidic problem, which were characterized by lower nitrogen availability and a higher total phosphorus content. Yet, no significant differences were found in bacterial community diversity and taxa composition between the two landuse soils. While, the specific predominant taxa, such as Proteobacteria, Actinobacteriota, Acidobacteriota, were more abundant in orchard soils than in farmland soils. Similarly, for most network parameters (such as node, edge, modularity), the higher values were gotten in orchard soils than farmland soils. By contrast, the progressive acidification of soil had a more significant impact on the structure and diversity of the bacterial community. The further statistical analysis indicated that except of soil pH, soil total phosphorus and nitrogen availability were also top factors shaping the bacterial communities' interaction. Based on predicted functional profiles, the function gene related to amino acid metabolism was higher enrichment in farmland soils than orchard soils, which was similar to most different functional categories between both soils except of amino acid transport and metabolism. Our results suggest that compared to soil pH controlling bacterial community structure and diversity, agricultural practices related to land use might regulate microbial activities involved in nutrients cycle in acidic soils of Jiaodong Peninsula.
Decoupling the Conductivity–Fluorescence Tradeoff of SnO2 Nanocrystals for Efficient and Stable Quantum Dot Light‐Emitting Diodes
Authors: Xia Xueqing , Chen Xingtong , Xie Jiachen , Li Xinrui , Chen Song 
Published: December 2024

AbstractElectron‐transporting layers (ETLs) assembled from SnO2 nanocrystals show promise in addressing the stability issues faced by solution‐processed quantum dot light‐emitting diodes (QLEDs). However, the electrical conductivity of SnO2 nanocrystals bottlenecks QLED performance, and efforts to achieve effective n‐type doping are constrained by dopant availability and charge‐induced exciton quenching. In response, Sb‐doped SnO2 nanocrystals with doping concentrations less than 1 mol% are explored, a range overlooked in previous research, and the ETL is designed accordingly. Comprehensive characterizations reveal that 0.45 mol% Sb doping transitions the electrical conduction from trap‐limited to trap‐free space‐charge‐limited, and 0.84 mol% doping results in Ohmic conduction, along with a 100‐fold conductivity enhancement. Meanwhile, trap‐filling mitigates the fluorescence quenching of the colloidal quantum dots, with significant increases only observed when doping concentrations exceed 0.45 mol%. Drawing inspiration from these findings, a SnO2 ETL with gradient Sb doping levels for QLEDs to decouple the conductivity–fluorescence tradeoff is developed. Consequently, this ZnO‐free QLED significantly outperforms comparable devices, achieving a luminance of 2.8 × 105 cd m−2, an external quantum efficiency of 18.3%, and a T95 operational lifetime of 4320 h at 1000 cd m−2, all while showing no signs of positive aging.
Compounds Containing 2,3‐Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin‐Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms
Authors: Padalino Gilda , Duggan Katrina , Mur Luis A. J. , Maillard Jean‐Yves , Brancale Andrea , Hoffmann Karl F. 
Published: December 2024

ABSTRACTAntimicrobial resistance remains a global issue, hindering the control of bacterial infections. This study examined the antimicrobial properties of 2,3‐N,N‐diphenyl quinoxaline derivatives against Gram‐positive, Gram‐negative, and Mycobacterium species. Two quinoxaline derivatives (compounds 25 and 31) exhibited significant activity against most strains of Staphylococcus aureus, Enterococcus faecium, and Enterococcus faecalis tested, with MIC values ranging from 0.25 to 1 mg/L. These compounds also showed effective antibacterial activity against methicillin‐resistant S. aureus (MRSA) and vancomycin‐resistant E. faecium/E. faecalis (VRE) strains. They demonstrated comparable or superior activity to four current antibiotics (vancomycin, teicoplanin, daptomycin, and linezolid) against a wide range of clinically relevant isolates. Additionally, they were more effective in preventing S. aureus and E. faecalis biofilm formation compared to several other antibiotics. In summary, these two quinoxaline derivatives have potential as new antibacterial agents.
Research on the Conditions and Operational Strategies of the Retailer's Participation in Omnichannel Returns Cooperation
Authors: Zheng Yanyan , Zhang Jin , Wang Tieshan , Wang Nengmin 
Published: December 2024

ABSTRACTIn the context of online retailing, many e‐commerce platforms have begun to explore omnichannel returns cooperation modes that are practical and satisfy consumers' offline channel preferences in response to the rising online return rate and the growth of consumer preference for returning products to physical stores. The purpose of this paper is to investigate what conditions the offline retailer will choose to participate in an omnichannel returns cooperation strategy and how the cooperation brings value to both sides of the alliance. Based on the consideration of consumers' differentiated purchase and return modes and whether the retailer participates in omnichannel returns cooperation, this paper first derives the consumer utility functions for the buy online and return online (BORO) mode, the buy offline and return offline (BS) mode, and the buy online and return in store (BORS) mode before and after the omnichannel returns cooperation. This paper then constructs profit expressions for an online e‐commerce platform and offline retailer before and after omnichannel returns cooperation and further explores the conditions and value of the offline retailer's willingness to participate in omnichannel returns cooperation. According to the study, the following interesting and important conclusions have been drawn. First, the participation of the offline brick‐and‐mortar retailer in an omnichannel returns strategy can introduce a new channel, which can help facilitate the integration of online and offline channels. Second, when the proportion of the online‐type consumer is low, the larger the critical point of composite return cross‐selling benefit required by the offline brick‐and‐mortar retailer, the lower the equilibrium price caused by their participation in omnichannel returns cooperation. Third, when the proportion of online‐type consumer exceeds a certain threshold and the online return cost of consumers is less than the offline return cost can the brick‐and‐mortar retailer enhance the return service experience to attract consumers and thus further increase profits. In the analyses of retail operations, these findings can offer guidance for the implementation of omnichannel returns and the development of appropriate operational plans for the physical business. The conclusions can provide directional suggestions for brick‐and‐mortar retailers to conduct omnichannel return practices and help formulate reasonable strategies for new retail operations.
Educational Interventions for Haemodialysis Patients in the Transplant Process: A Systematic Review
Authors: Oriol‐Vila Ester , Rota‐Musoll Laura , Molina‐Robles Esmeralda , Roure‐Pujol Carme , Chiverches‐Pérez Emilia 
Published: December 2024

ABSTRACTAimTo systematically evaluate empirical studies investigating nursing educational interventions for patients with haemodialysis at the different stages of cadaveric kidney transplantation and synthesise these findings.DesignA systematic review of clinical interventions.MethodsOn clinical trials published in Spanish and English, between January 2005 and July 2022, in the main databases. The number of studies identified is shown in the flowchart of the PRISMA review. For the critical assessment of the scientific quality of the studies, the CASPe checklist and the Cochrane risk of bias assessment tool were applied.ResultsEleven studies were obtained in which nursing educational interventions focused on posttransplantations and one that considered care from the person's admission to hospital were evaluated. The results obtained identified four themes: health education, empowerment, quality of life and holistic patient care with the help of different support methods, including individual and personalised support, group format and informational support via an educational brochure, telephone and website.ConclusionThe reviewed studies suggest that after receiving educational interventions patient dialysis treatment and kidney transplant recipient, have better health outcomes.Patient ContributionLarger studies are needed to promote a comprehensive and continuous self‐care model throughout the kidney transplant process.Implications for Nursing Health EducationNursing educational interventions are necessary throughout the transplantation process for the patient dialysis and the family in a comprehensive and continuous manner. In the future, clinical trial studies are needed at the pretransplantation stage.
Decreased Postoperative Emesis and Opioid Use After Implementation of ERAS Protocol for Free Flap Surgery
Authors: Siegel Jesse K. , Gomez Kayeromi , Bier‐Laning Carol 
Published: December 2024

AbstractObjectiveEnhanced recovery after surgery (ERAS) protocols are designed to improve postoperative outcomes. In this study, we compare outcomes for patients undergoing head and neck free flap surgery at a quaternary care institution before and after an ERAS protocol was implemented.Study DesignRetrospective study.SettingSingle quaternary care center.MethodsRetrospective evaluation of outcomes from patients who underwent head and neck surgery with free flap reconstruction prior to ERAS (January 2018 to May 2022, baseline) with patient outcomes after implementation (June 2022 to September 2023, ERAS). Outcomes studied included length of stay (LOS), opioid utilization, postoperative emesis, readmission, and mortality.ResultsPatients in the ERAS group had significantly lower opioid utilization (206.84 ± 217 morphine milligram equivalent vs 415.53 ± 431, P < .01) and significantly lower rates of postoperative emesis (1.74% vs 28.27%, P < .01). This difference in emesis remained significant in the subgroup of patients who underwent total laryngectomy. The decreases in opioid use and emesis remained significant in multivariate analyses controlling for demographic factors and surgery type. We found no significant decrease in LOS or mortality.ConclusionIn the year after implementing an ERAS protocol for head and neck free flap surgery, we found significantly lower opioid utilization and the unique finding of lower postoperative emesis overall, including in the laryngectomy subgroup for whom emesis‐induced fistula is most impactful. No difference was noted in LOS or mortality. To our knowledge, this is the first study of an ERAS protocol for head and neck surgery to show a decrease in postoperative emesis.
Development and Validation of a Shortened Severity Measurement Tool for Tinnitus
Authors: Mueller Lauren , Dear Emma R. , Turcois Juan , Frumkin Madelyn R. , Smith Harrison , Kallogjeri Dorina , Rodebaugh Thomas L. , Piccirillo Jay F. 
Published: December 2024

AbstractObjectiveThere is a need to develop and validate a brief questionnaire to measure tinnitus severity that can meet the needs of clinicians and researchers. The objective of this study is to demonstrate the validity and reliability of the 9‐item Tinnitus Severity Short Form (TS‐SF).Study DesignA cohort study of online survey respondents recruited in October 2020 from the American Tinnitus Association electronic mailing list with a 2‐week follow‐up time interval.SettingOnline.MethodsFace and content validity, factor analysis, internal consistency, convergent validity, reliability, and minimal clinically important difference (MCID) were analyzed.ResultsOf 1121 participants that started the survey, 325 (29%) completed the baseline TS‐SF. Through confirmatory factor analysis, the 9‐item survey demonstrated a bifactor model with a substantive distress factor and a method factor. The instrument had high internal consistency with Cronbach's α of .96. Convergent validity determined the TS‐SF score to be a predictor of tinnitus severity. Of 261 follow‐up respondents, the test‐retest reliability of r = 0.69 (95% confidence interval, 0.62‐0.75) was determined. The MCID was determined using a distribution approach to be a 12‐point change.ConclusionThe TS‐SF demonstrates good internal consistency, validity, and reliability. This patient‐reported outcome measure for tinnitus can be used in tinnitus treatment trials and clinical practice. The 9‐item survey is less likely to result in respondent survey fatigue than longer surveys, and the 2‐week reference interval allows for monitoring of tinnitus severity change in an appropriate timeframe.
The Prevalence of Central Sleep Apnea in New Referrals to a Sleep Surgery Clinic
Authors: Rodin Julianna G. , Harkins Tice , Kent Erica , Phung Chau , Khan Rafa , Seay Everett , Keenan Brendan T. , Dedhia Raj C. 
Published: December 2024

AbstractObjectiveSurgical treatment of non‐obstructive sleep apnea (OSA) pathology poses the risk of inappropriate surgical indications. Herein, we sought to determine the prevalence of non‐OSA respiratory disorders, specifically central sleep apnea (CSA), in new referrals to a Sleep Surgery Clinic.Study DesignProspective observational review.SettingTertiary care academic medical center.MethodsIn a sleep surgery clinic cohort, the presence of clinically significant CSA was defined as having >25% of the total apnea‐hypopnea index (AHI) being central and/or mixed events. Demographics, comorbid disorders, patient‐reported outcome measurements, and sleep study results were compared among patients using linear or logistic regression analysis, unadjusted and adjusted for age, sex, and body mass index (BMI).ResultsOn average, the cohort (n = 295) was male (74%), middle‐aged (mean [±SD] 54.2 ± 13.9 years), and overweight (BMI 30.3 ± 5.4), with severe sleep apnea (AHI 30.6 ± 22.6 events/h). Twenty‐nine patients (9.8%) were found to have clinically significant CSA yet only 10% of these cases carried a diagnosis of CSA upon presentation. The remainder were identified by reviewing the pre‐visit sleep study tables (35%), raw data (17%), and tables and raw data of a repeat post‐visit study (38%). Patients with CSA were older and had evidence of more cardiac comorbidities.ConclusionThe prevalence of CSA in new referrals to a Sleep Surgery Clinic was nearly 1 in 10 despite only 1% (3 of 295) with a known diagnosis upon presentation. Sleep surgeons must remain vigilant for patients with occult CSA, especially in older patients with a history of significant cardiovascular disease.
Machine Perfusion Technology for Reduction of the Risk of Non‐Anastomotic Biliary Stricture in Liver Transplantation
Authors: Zhang Jiayi , Li Yuexin , Mo Runbing , Wang Haoxuan , Chen Jianyu , Guo Zhiyong 
Published: December 2024

ABSTRACTIn many countries, use of organs sourced by donation after circulatory death can effectively alleviate the present organ shortage. However, biliary complications, particularly non‐anastomotic biliary stricture, following transplantation of livers from donation after circulatory death donors significantly affects the prognosis of the recipient and limits organ utilization. Recent rapid advances in machine technology have improved post‐transplant graft function and been shown to protect against non‐anastomotic biliary stricture. This review summarizes the protective mechanisms and clinical outcomes of hypothermic oxygenated machine perfusion, normothermic machine perfusion, and normothermic regional perfusion for donation after circulatory death liver transplantation and discusses the prospects for further development of machine perfusion and ischemia‐free organ transplantation technology.