bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lymph Node Positivity in One-Step Nucleic Acid Amplification is a Prognostic Factor for Postoperative Cancer Recurrence in Patients with Stage II Colorectal Cancer: A Prospective, Multicenter Study
Authors: Itabashi Michio , Yamamoto Hirofumi , Tomita Naohiro , Inomata Masafumi , Murata Kohei , Hayashi Shigeoki , Miyake Yasuhiro , Igarashi Seiji , Kato Takeshi , Noura Shingo , Furuhata Tomohisa , Ozawa Heita , Takemasa Ichiro , Yasui Masayoshi , Takeyama Hiroshi , Okamura Shu , Ohno Yuko , Matsuura Nariaki 
Published: November 2019

Abstract

Background
For colorectal cancer (CRC) patients, the standard histological lymph node (LN) evaluation has low sensitivity. Our previously developed one-step nucleic acid amplification (OSNA™) assay measures cytokeratin 19 gene expression in whole LNs. We recently showed that 17.6% of pN0 stage II CRC patients were OSNA positive, suggesting a correlation between OSNA results and disease recurrence. This multicenter, prospective study investigateed the prognostic value of the OSNA assay for pStage II CRC patients.

Methods
We examined 204 CRC patients who were preoperatively diagnosed as cN0 and cN1 and surgically treated at 11 medical institutions across Japan. Nine patients were excluded, and 195 patients (Stage I: n = 50, Stage II: n = 70, Stage III: n = 75) were examined. All LNs, harvested from patients, were examined histopathologically using one-slice hematoxylin–eosin staining. Furthermore, half of the LNs was examined by the OSNA assay. Patients were classified according to the UICC staging criteria and OSNA results, and the 3-year, disease-free survival (DFS) of each cohort was analyzed.

Results
Average 21.2 LNs/patient were subject to pathological examination. Approximately half of all harvested LNs (average, 9.4 LNs/patient) were suitable for the OSNA assay. Significantly lower 3-year DFS rates were observed in pStage (pathological Stage) II OSNA-positive patients than in OSNA-negative patients (p = 0.005). Among all assessed clinical and pathological parameters, only the OSNA result significantly affected 3-year DFS rates in pStage II CRC patients (p = 0.027).

Conclusions
This study shows that OSNA positivity is a risk factor for recurrence of the patients with pStage II CRC.
Duty senior nurse and unit coordinator roles in terms of burnout: a survey
Authors: McArdle Simon , Sherring Simon , Adzinku Francis , Nazzal Mazen 
Published: November 2019

Background/Aims: Stress-related burnout among nursing staff has been found to negatively affect their attitude and to impact patient satisfaction and mortality. The aim of this article was to study stress-related burnout among duty senior nurses and unit coordinators. Methods: An electronic survey was sent to all duty senior nurses/unit coordinators (n=50) at one London Mental Health Trust. A total of 27 duty senior nurses/unit coordinators responded (54% response rate). Results: Age and number of years in clinical practice were protective factors against stress-related burnout in staff acting as Senior Duty Nurses or Unit Coordinators. Conclusion: Further training, staff support and better coordination with the police are some of the areas that need addressing to support staff in the role and to improve service delivery.
The role of antimicrobials in management of periodontal diseases
Authors: Firdaus Bilawal Aziz , Sharma Praveen , Milward Michael 
Published: November 2019

With the looming threat posed by antimicrobial resistance, appropriate prescribing of antimicrobials, including antibiotics, is increasingly relevant. In this article, the reasons why antimicrobial therapy is not the mainstay of treatment for most patients with periodontitis will be explored. Some specific exceptions to this rule will also be investigated, including why such exceptions exist. In addition, the protocols for periodontal and antimicrobial therapy to maximize the treatment response when adjuvant antimicrobials are used will be presented. CPD/Clinical Relevance: This article highlights the need for appropriate prescribing within dentistry as a whole and specifically when it comes to the management of periodontal diseases, where antimicrobials do not form the mainstay of treatment, with some exceptions.
Managing the consequences of periodontal diseases/treatment: gingival recession
Authors: Bahal Priya , Malhi Meenakshi , Shah Sajni , Ide Mark 
Published: November 2019

Gingival recession is a widespread clinical finding that can lead to discomfort, root caries and periodontal problems for some patients, yet be of no consequence for others. There are certain factors which may increase the risk of significant recession, and likewise a range of management strategies exist. The causes, identification, risk factors and treatment options for recession are discussed. This will allow the practitioner to recognize the most suitable treatment options in conjunction with the patient, following an informed discussion and, if appropriate, refer for further care. CPD/Clinical Relevance: Whilst gingival recession may be nothing more than a minor inconvenience for some patients, in certain cases it can present a significant problem for patients requiring professional interventions including surgery. This article summarizes the aetiology, diagnosis and management options available.
Biomodulation induced by fluorescent light energy versus standard of care in venous leg ulcers: a retrospective study
Authors: Dini Valentina , Janowska Agata , Davini Giulia , Kerihuel Jean-Charles , Fauverghe Stéphane , Romanelli Marco 
Published: November 2019

Objective: The recently completed EUREKA study confirmed the efficacy and safety profile of fluorescent light energy (FLE) in treating hard-to-heal wounds. To supplement the EUREKA prospective, observational, uncontrolled trial results, researchers selected one of the EUREKA clinical centres to conduct a retrospective analysis of matching wound care data for 46 venous leg ulcers (VLU) patients who had received standard wound care over a five-year period, compared with 10 EUREKA VLU subjects. Method: The study centre selected 46 patients with VLUs based on the matching criteria (wound age and size, patient's age and gender). They compared the healing rates of these matching VLUs with 10 VLU patients treated at the same centre during the EUREKA study. Results: The EUREKA patients had larger and significantly older wounds (p<0.05) and significantly more risk factors (p<0.05) than the matching wounds. However, they had better outcomes (EUREKA: 40% versus matching group: 7% for full wound closure by 16 weeks). No wound breakdown was observed at 16 weeks in the EUREKA group, compared with 25% in the matching group. No EUREKA patient developed infections requiring antibiotics, compared with 37% in the matching group. EUREKA wounds had a mean relative wound area regression (RWAR) of 32% at week six and 50% at week 16, compared with −3% at week six and −6% at week 16 for the matching group. Conclusion: These findings show that the system based on FLE was well-tolerated and efficacious, with better clinical outcome results compared with the wounds analysed in this retrospective matching study and treated with standard of care alone.
Bromelain-based enzymatic debridement of e-cigarette burns: a single unit experience
Authors: Ho Weiguang , Jones Christopher D. , Widdowson Daniel , Bahia Hilal 
Published: November 2019

Objective: It is widely accepted that the early debridement of burns improves outcome. There is increasing evidence that enzymatic debridement is an effective technique for removal of full-thickness and deep-dermal burns, reducing blood loss and often the need for autologous skin grafting by avoiding over excision of the burn. We aim to highlight the potential use of this form of debridement as an alternative to surgical management in patients with electronic cigarette (e-cigarette)-associated flame burn injuries. Methods: This case series presents the use of Nexobrid (MediWound Ltd, Israel), a non-surgical, bromelain-based enzymatic debridement technique, in patients with deep partial-thickness burns (range: 1–3% total body surface area), avoiding the need for autologous skin grafting. Results: Burn wounds in two patients healed within 14 days without complications or the need for further surgical intervention. Another patient required further dressings after discharge but failed to attend follow-up appointments. These results are comparable with those reported by others using conservative management of e-cigarette burns. Conclusion: The authors wish to raise awareness of the potential for a combination of thermal and chemical burns related to e-cigarette explosions. Chemical burns should be excluded by pH testing of the burn wound. From our experience, small e-cigarette-associated flame burns can be considered for management with enzymatic debridement.
Nonlinear simulation of an elastic tumor-host interface
Authors: Lu Min-Jhe , Liu Chun , Li Shuwang 
Published: November 2019

Abstract
We develop a computational method for simulating the nonlinear dynamics of an elastic tumor-host interface. This work is motivated by the recent linear stability analysis of a two-phase tumor model with an elastic membrane interface in 2D [47]. Unlike the classic tumor model with surface tension, the elastic interface condition is numerically challenging due to the 4th order derivative from the Helfrich bending energy. Here we are interested in exploring the nonlinear interface dynamics in a sharp interface framework. We consider a curvature dependent bending rigidity (curvature weakening [22]) to investigate metastasis patterns such as chains or fingers that invade the host environment. We solve the nutrient field and the Stokes flow field using a spectrally accurate boundary integral method, and update the interface using a nonstiff semi-implicit approach. Numerical results suggest curvature weakening promotes the development of branching patterns instead of encapsulated morphologies in a long period of time. For non-weakened bending rigidity, we are able to find self-similar shrinking morphologies based on marginally stable value of the apoptosis rate.
Arguing with “at least” constructions
Authors: Katzir Nicole 
Published: November 2019

AbstractBased on corpus data from the Hebrew web corpus HeTenTen, I analyze the discourse argumentative functions of constructions associated with superlative minimum modifiers (e. g.at least). I adopt Kay’s (1992. At least. In Adrienne Lehrer & Eva Feder Kittay (eds.),Frames, fields, and contrasts: New essays in semantic and lexical organization, 309–331. Hillsdale, NJ: Erlbaum) distinction between three such sub-constructions: Scalar, Rhetorical and Evaluative, but I offer further distinctions within these constructions. Most importantly, despite the differences between them, I argue that all three constructions are used to constructnon-optimal, yet sufficientarguments.
The Rise of Urbanized Landscapes in Mesopotamia: The QADIS Integrated Survey Results and the Interpretation of Multi-Layered Historical Landscapes
Authors: Marchetti Nicolò , Al-Hussainy Abbas , Benati Giacomo , Luglio Giampaolo , Scazzosi Giulia , Valeri Marco , Zaina Federico 
Published: November 2019

Abstract
This paper draws on the preliminary results of the QADIS survey project, conducted by the University of Bologna and the Iraqi State Board of Antiquities and Heritage since 2016 in the Qadisiyah province. The project addresses phenomena related to anthropogenic transformation of landscapes in a region that was at the core of the early Mesopotamian urbanization process. Building upon the seminal work conducted by R. McC. Adams in the 1960 s and 1970 s, we implemented an integrated documentation technique to reconstruct at regional levels the changes in the dense network of human settlements and artificial water infrastructures characterizing the evolution of this archaeological landscape over time. The aim of the article is that of providing a finer-grained regional picture of 4th and 3rd millennium BC urban developments which can be useful for better conceptualizing the scale and pace of early Mesopotamian urbanism.
Künstliche Intelligenz: Chancen, Risiken und strategische Governance
Authors: Wirtz Bernd W. , Weyerer Jan C. 
Published: November 2019

Künstliche Intelligenz hat einen erheblichen Bedeutungszuwachs in der Wissenschaft und Praxis in den letzten Jahren erfahren und durchdringt mit ihren vielfältigen Erscheinungsformen und Anwendungsbereichen zunehmend unsere Wirtschaft und Gesellschaft. Der vorliegende Artikel baut auf dem Beitrag „Künstliche Intelligenz: Erscheinungsformen, Nutzungspotenziale und Anwendungsbereiche“ der Autoren (siehe WiSt, Nr. 10/2019, S. 4 ff.) auf und stellt wesentliche Chancen und Risiken von künstlicher Intelligenz sowie einen strategischen KI-Governance-Ansatz dar, um entsprechende Risiken zu minimieren und Chancen zu verbessern.
Editorial
Authors: Núñez-Rodríguez José de Jesús 
Published: November 2019

Durante 8 ediciones la Revista Electrónica AiBi, bajo la Coordinación de la Dirección de Investigaciones de la Universidad de Santander (UDES), Campus Universitario de Cúcuta, ha venido entregando, semestralmente, a la comunidad académica, y público en general, las producciones investigativas de prestigiosos estudiosos de la región y del ámbito internacional sobre importantes temáticas relacionadas con las disciplinas administrativas, tecnológicas, del desarrollo, educación y ambiente. En esta edición, identificada con el Volumen, 5 N° 1-2017, AiBi pone a disposición de los lectores 6 artículos, distribuidos en 4 productos de investigación y 2 de reflexión. El primero de ellos, es una investigación realizada por Ramírez, T.; Carbone, R.; Vivas, G.; Vásquez, J. bajo el título de “Residuos de plaguicidas organofosforados (OPPs) en suelos del Municipio José María Vargas, Táchira-Venezuela”, en la cual se presentan los resultados de un interesante análisis de las trazas de pesticidas en los suelos de una importante región productora de hortalizas del Estado Táchira, en límites con la República de Colombia. Como resultado se puede decir que 6 de los 7 pesticidas estudiados fueron detectados en las 8 localidades. Del total de parcelas (75) estudiadas el 65,33% (49 parcelas) presentaron residuos de OPPs. El Clorpirifos se encuentra presente en todas las aldeas estudiadas, en cuanto al Malation este no fue detectado. Esto podría sugerir que la contaminación con estos plaguicidas, quizás, sea debido a grandes cantidades aplicadas y alta frecuencia de aplicación.
Prospective Biomarker Study in Advanced RAS Wild-Type Colorectal Cancer: POSIBA Trial (GEMCAD 10-02)
Authors: García-Albéniz Xabier , Alonso Vicente , Escudero Pilar , Méndez Miguel , Gallego Javier , Rodríguez Jose Ramon , Salud Antonia , Fernández-Plana Julen , Manzano Hermini , Zanui Montserrat , Falcó Ester , Feliu Jaime , Gil Mireia , Fernández-Martos Carlos , Bohn Uriel , Alonso Carmen , Calderero Verónica , Rojo Federico , Cuatrecasas Miriam , Maurel Joan 
Published: November 2019

Abstract

Background
RAS testing is used to select patients with anti-epidermal growth factor receptor (EGFR) therapies sensitivity in metastatic colorectal cancer (mCRC). However, other biomarkers such as BRAF, PIK3CA/PTEN, and p-IGF-1R+/MMP7+ (double positive [DP] phenotype) have not been prospectively assessed to predict anti-EGFR resistance.

Materials and Methods
We designed a multicenter prospective trial (NCT01276379) to evaluate whether the biomarkers BRAF mutation, PIK3CA mutation/PTEN loss, and DP phenotype can improve the prediction for 12-months progression-free survival (PFS) over the use of clinical variables exclusively in patients with RAS wild-type (WT) mCRC treated with standard chemotherapy plus biweekly cetuximab as first-line therapy. The planned sample size was 170 RAS WT patients to detect a 20% difference in 12-month PFS based on the analysis of clinical and selected biomarkers (α = .05, β = .2). The discriminatory capacity of the biomarkers was evaluated using receiver operating characteristic curves.

Results
We included 181 RAS WT patients. The biomarker distribution was as follows: BRAF mutant, 20 patients (11%); PIK3CA mutated/PTEN loss, 98 patients (58%); DP, 23 patients (12.7%). The clinical variables in the clinical score were progression status &gt;0, left-sided tumor, and resectable liver metastasis as the only metastatic site. The area under the curve (AUC) of the score containing the clinical variables was 0.67 (95% confidence interval [CI], 0.60–0.75). The AUC of the score with clinical variables and BRAF mutational status was 0.68 (0.61–0.75, p = .37). The AUC of the score with clinical variables and PI3KCA mutation/PTEN status was 0.69 (0.61–0.76, p = .32). The AUC of the score with clinical variables and DP phenotype was 0.66 (0.58–0.73, p = .09).

Conclusion
The addition of BRAF, PIK3CA/PTEN, and DP to a clinical score does not improve the discrimination of 12-month PFS.

Implications for Practice
This prospective biomarker design study has important clinical implications because many prospective clinical trials are designed with the hypothesis that BRAF mutation per se and MEK and PIK3CA downstream pathways are critical for colorectal tumor survival. The results lead to the question of whether these pathways should be considered as passengers instead of drivers.
Hemşirelerin opioid kullanımına yönelik tutumları:Bir eğitim ve araştırma hastanesinde anket çalışması
Authors: BALDEMİR Ramazan , AKÇABOY Erkan Yavuz , NOYAN Özgen , ÇELİK Şeref , AKÇABOY Zeynep Nur 
Published: November 2019

Amaç:
Opioidler, güçlü analjezik etkilerinden dolayı ağrı yönetiminde kullanılan
önemli ilaçlardandır. Bununla birlikte sağlık çalışanlarında tespit edilen opiofobiye bağlı olarak
ağrı tedavisinde opioid kullanımı istenen seviyelerde değildir. Bu
çalışmada amaç, hemşirelerin ağrı tedavisinde opioid kullanımına yönelik tutum
ve yaklaşımlarıyla, bu tutum ve yaklaşımların ağrı tedavisine etkisini
belirlemektir.

Gereç ve Yöntem: Etik kurul onayı alındıktan
sonra Ankara Numune Eğitim ve Araştırma Hastanesi’nde çalışan
ve anketin yapıldığı süre içerisinde izinli olmayan bütün hemşirelere
ulaşılması hedeflendi. 31
sorudan oluşan anket formunu toplam 300 hemşire gönüllü olarak doldurmak
istedi. 101 adet anket formu %33,6 katılım oranı ile doldurulmuş olarak teslim
alındı. Veri analizi için SPSS 15.0
istatistik paket programı kullanıldı.

Bulgular: Çalışmaya
katılan 101 hemşirenin %80’i hastalara opioid tedavisi uygularken tedirgin
olduğunu belirtmiştir. Bu tedirginliğin ana sebebi, opioidlerin potansiyel yan
etkileri ve bağımlılık riski olarak tespit edildi. Hemşirelerin %67,6’sı
opioidlerin yalnızca kanser hastalarında kullanılması gerektiğini
düşünmektedir. Hemşirelerin %58’i denetime tabi ilaçlardan olduğundan yasal
sorumluluk almamak adına opioidleri hastalara uygulamak istemediğini
belirtmiştir. Hemşirelerin %82’si hastalar opioid ilaç kullanmak istemezse bu
konuda hastaları desteklediklerini belirtmiştir. Hemşirelerin %36,1’i opioid
grubu olmayan bazı ilaçları opioid grubu
olarak bilmektedir.

Sonuç: Bu çalışmada, opioid kullanımı ile ilgili olarak,
hemşirelerde yetersiz bilgi ve önyargıların olduğu sonucuna ulaşıldı. Bu
nedenle, opioidlerle ilgili hemşirelere verilecek eğitimlerin gereklilik
olduğunu ve bu eğitimlerin düzenli olarak verilmesi gerektiğini düşünmekteyiz.
The immediate results of combined operations in patients with advanced ovarian cancer: the experience of N. N. Blokhin National Medical research Center of Oncology, Ministry of health of russia
Authors: Kozhevnikova O. V. , Nikogosyan S. A. , Ananyev V. S. , Kyznetsov V. V. , Shevchuk A. S. 
Published: November 2019

Objective: to analyze intraoperative and postoperative complications in patients who underwent combination surgeries for advanced ovarian cancer.Materials and methods. This retrospective study included patients that underwent primary or interval cytoreductive combination surgeries for advanced (grade III–IV) ovarian cancer at N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia between 2000 and 2017.Results. We analyzed medical records of 144 patients with grade III–IV ovarian cancer who underwent combination surgery at some stage of their treatment. Almost two-thirds of patients (64.8 %) had complete or optimal volume of surgery. Intraoperative complications were registered in 7 % of patients (n = 10), while postoperative complications were observed in 38.2 % of cases (n = 55). The postoperative death rate was 0.7 % (n = 1).Conclusions. Higher frequency of complete and optimal cytoreduction, as well as acceptable level of intra- and postoperative complications confirm the need for combination surgeries in patients with advanced ovarian cancer. Aggressive surgical tactics should be used only in specialized cancer hospitals with the involvement of a multidisciplinary team that includes cancer surgeons and anesthesiologists in order to improve both short-term and long-term treatment outcomes in patients with advanced ovarian cancer.
СИСТЕМНО-СИНЕРГЕТИЧНИЙ ПІДХІД У ДОСЛІДЖЕННІ ФУНКЦІОНУВАННЯ БАНКІВСЬКОЇ СИСТЕМИ
Authors: Ткачук Наталія 
Published: November 2019

Розглянуто сутність банківської системи за системним і синергетичним підходами. Розкрито системні характеристики банківської системи: цілісність, ієрархічність, інтегративність, комунікативність та інші. Доведено необхідність застосування синергетичного підходу в дослідженні особливостей функціонування банківської системи за умов синергійного ринку. Запропоновано доповнити перелік системних характеристик банківської системи такими ознаками, як: складність, динамічність, відкритість, нелінійність, нерівноважність, когерентність і здатність до самоорганізації, що робить можливим розуміння її сутності більш повним і реалістичним. Зазначено, що нелінійність і нерівноважність є головними джерелами різноманітності та складності економічної динаміки функціонування банківської системи. Динамічність банківської системи визначаться тим, що її структура, цілі і зв’язки між елементами є непостійними, вони змінюються і розвиваються в часі. Розглянуто відкритість банківської системи як широкий спектр вертикальних і горизонтальних інформаційних, економічних та інших зв’язків із зовнішнім середовищем. Оптимальними передумовами функціонування банківської системи є її самоорганізація і функціональна стійкість у нерівноважних умовах. Підкреслено, що процеси самоорганізації можуть відбуватися в банківській системі лише за умови високого рівня її складності, динамічності та непередбачуваності в довгостроковому періоді.
ОЦІНКА ВПЛИВУ ІНСТИТУЦІЙНИХ ТРАНСФОРМАЦІЙ НА ЯКІСТЬ СИСТЕМИ ЗАБЕЗПЕЧЕННЯ ФІНАНСОВОЇ СТАБІЛЬНОСТІ КРЕДИТНИХ УСТАНОВ В УКРАЇНІ
Authors: Хуторна Мирослава 
Published: November 2019

Досліджено якість системи забезпечення фінансової стабільності кредитних установ, звертаючи увагу на такі її ознаки: стійкість, результативність, функціональна безперервність, раціональність взаємозв’язків між елементами. Питання якості досліджуваної системи розглянуто в контексті інституційних трансформацій. Розкрито зміст інституційних змін в організації взаємодії між суб’єктами системи забезпечення фінансової стабільності кредитних установ в Україні. Здійснення порівняльного аналізу рівня розвитку досліджуваної системи на світовому, наднаціональному і національному рівнях дозволило зробити висновок, що до 2011 року в Україні існувала сукупність інституцій зі слабко налагодженою комунікацією, які розрізнено розвивали методологію забезпечення фінансової стійкості підпорядкованих їм різновидів кредитних установ. Обґрунтовано перспективну інституційно-функціональну схему взаємодії суб’єктів забезпечення фінансової стабільності кредитного сегмента фінансового сектору і визначено передумови її успішної практичної імплементації.