bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reframing Climate-Induced Socio-Environmental Conflicts: A Systematic Review
Authors: Scartozzi Cesare M 
Published: September 2020

AbstractThis article draws a comprehensive map of conflict climate change scholarship. It uses visualizations and descriptive statistics to trace the temporal, spatial, and topical evolution of the field of study via a bibliometric analysis of more than six hundred publications. It then proceeds to summarize findings, theoretical explanations, and methodological approaches. Overall, this systematic review shows a remarkable inconsistency of evidence among publications. As a way forward, this article recommends future research to use computational models, informed by a social-ecological perspective, to better explore the link between climate change and conflict.ResumenEn este artículo se traza un mapa integral de la erudición conflictiva del cambio climático. Se utilizan visualizaciones y estadísticas descriptivas para rastrear la evolución temporal, espacial y temática del campo de estudio mediante un análisis bibliométrico de más de seiscientas publicaciones. Luego, continúa con un resumen de los hallazgos, las explicaciones teóricas y los enfoques metodológicos. En términos generales, esta revisión sistemática muestra una notable incoherencia de evidencias entre las publicaciones. En este artículo se recomiendan investigaciones a futuro para utilizar los modelos computacionales, informados con una perspectiva socioecológica, a fin de explorar mejor la conexión entre el cambio climático y los conflictos.ExtraitCet article offre une représentation complète des recherches portant sur les conflits liés au changement climatique. Il utilise des visualisations et des statistiques descriptives pour retracer l’évolution temporelle, spatiale et thématique de ce domaine d’étude via une analyse bibliométrique de plus de six cents publications. Il résume ensuite les constatations, explications théoriques et approches méthodologiques. Globalement, cette synthèse systématique montre une incohérence remarquable des preuves entre les publications. Pour aller de l'avant, cet article recommande que les recherches futures passent par des modèles informatiques éclairés par une perspective socio-écologique pour mieux explorer le lien entre le changement climatique et les conflits.
In vitro and in vivo activities of imipenem combined with BLI-489 against class D β-lactamase-producing Acinetobacter baumannii
Authors: Wang Yung-Chih , Huang Shu-Wei , Chiang Ming-Hsien , Lee I-Ming , Kuo Shu-Chen , Yang Ya-Sung , Chiu Chun-Hsiang , Su Ying-Shih , Chen Te-Li , Wang Fu-Der , Lee Yi-Tzu 
Published: September 2020

Abstract

Background
According to our preliminary study, BLI-489 has the potential to inhibit the hydrolysing activity of OXA-51-like β-lactamase produced by carbapenem-resistant Acinetobacter baumannii (CRAb).

Objectives
In the present study, the in vitro and in vivo activities of imipenem combined with BLI-489 against CRAb producing carbapenem-hydrolysing class D β-lactamases (CHDLs), namely OXA-23, OXA-24, OXA-51 and OXA-58, were determined.

Methods
A chequerboard analysis of imipenem and BLI-489 was performed using 57 and 7 clinical CRAb isolates producing different CHDLs and MBLs, respectively. Four representative strains harbouring different CHDL genes were subjected to a time–kill assay to evaluate the synergistic effects. An in silico docking analysis was conducted to simulate the interactions between BLI-489 and the different families of CHDLs. The in vivo activities of this combination were assessed using a Caenorhabditis elegans survival assay and a mouse pneumonia model.

Results
Chequerboard analysis showed that imipenem and BLI-489 had a synergistic effect on 14.3, 92.9, 100, 16.7 and 100% of MBL-, OXA-23-, OXA-24-like-, OXA-51-like- and OXA-58-producing CRAb isolates, respectively. In the time–kill assay, imipenem and BLI-489 showed synergy against OXA-24-like-, OXA-51-like- and OXA-58-, but not OXA-23-producing CRAb isolates after 24 h. The in silico docking analysis showed that BLI-489 could bind to the active sites of OXA-24 and OXA-58 to confer strong inhibition activity. The combination of imipenem and BLI-489 exhibited synergistic effects for the rescue of CRAb-infected C. elegans and mice.

Conclusions
Imipenem combined with BLI-489 has synergistic effects against CHDL-producing CRAb isolates.
Proxy indicators to estimate the appropriateness of medications prescribed by paediatricians in infectious diseases: a cross-sectional observational study based on reimbursement data
Authors: Thilly N , Pereira O , Schouten J , Hulscher M E J L , Pulcini C 
Published: September 2020

Abstract

Background
We previously developed proxy indicators (PIs) that can be used to estimate the appropriateness of medications used for infectious diseases (in particular antibiotics) in primary care, based on routine reimbursement data that do not include clinical indications.

Objectives
To: (i) select the PIs that are relevant for children and estimate current appropriateness of medications used for infectious diseases by French paediatricians and its variability while using these PIs; (ii) assess the clinimetric properties of these PIs using a large regional reimbursement database; and (iii) compare performance scores for each PI between paediatricians and GPs in the paediatric population.

Methods
For all individuals living in north-eastern France, a cross-sectional observational study was performed analysing National Health Insurance data (available at prescriber and patient levels) regarding antibiotics prescribed by their paediatricians in 2017. We measured performance scores of the PIs, and we tested their clinimetric properties, i.e. measurability, applicability and room for improvement.

Results
We included 116 paediatricians who prescribed a total of 44 146 antibiotic treatments in 2017. For all four selected PIs (seasonal variation of total antibiotic use, amoxicillin/second-line antibiotics ratio, co-prescription of anti-inflammatory drugs and antibiotics), we found large variations between paediatricians. Regarding clinimetric properties, all PIs were measurable and applicable, and showed high improvement potential. Performance scores did not differ between these 116 paediatricians and 3087 GPs.

Conclusions
This set of four proxy indicators might be used to estimate appropriateness of prescribing in children in an automated way within antibiotic stewardship programmes.
Informative presence and observation in routine health data: A review of methodology for clinical risk prediction
Authors: Sisk Rose , Lin Lijing , Sperrin Matthew , Barrett Jessica K , Tom Brian , Diaz-Ordaz Karla , Peek Niels , Martin Glen P 
Published: September 2020

AbstractObjectiveInformative presence (IP) is the phenomenon whereby the presence or absence of patient data is potentially informative with respect to their health condition, with informative observation (IO) being the longitudinal equivalent. These phenomena predominantly exist within routinely collected healthcare data, in which data collection is driven by the clinical requirements of patients and clinicians. The extent to which IP and IO are considered when using such data to develop clinical prediction models (CPMs) is unknown, as is the existing methodology aiming at handling these issues. This review aims to synthesize such existing methodology, thereby helping identify an agenda for future methodological work.Materials and MethodsA systematic literature search was conducted by 2 independent reviewers using prespecified keywords.ResultsThirty-six articles were included. We categorized the methods presented within as derived predictors (including some representation of the measurement process as a predictor in the model), modeling under IP, and latent structures. Including missing indicators or summary measures as predictors is the most commonly presented approach amongst the included studies (24 of 36 articles).DiscussionThis is the first review to collate the literature in this area under a prediction framework. A considerable body relevant of literature exists, and we present ways in which the described methods could be developed further. Guidance is required for specifying the conditions under which each method should be used to enable applied prediction modelers to use these methods.ConclusionsA growing recognition of IP and IO exists within the literature, and methodology is increasingly becoming available to leverage these phenomena for prediction purposes. IP and IO should be approached differently in a prediction context than when the primary goal is explanation. The work included in this review has demonstrated theoretical and empirical benefits of incorporating IP and IO, and therefore we recommend that applied health researchers consider incorporating these methods in their work.
A Comparison of Late Mortality Among Survivors of Childhood Cancer in the United States and United Kingdom
Authors: Fidler-Benaoudia Miranda M , Oeffinger Kevin C , Yasui Yutaka , Robison Leslie L , Winter David L , Reulen Raoul C , Leisenring Wendy M , Chen Yan , Armstrong Gregory T , Hawkins Michael M 
Published: September 2020

Abstract

Background
It is unclear whether late-effect risks among childhood cancer survivors vary internationally. We compared late mortality in the North American Childhood Cancer Survivor Study (CCSS) and British Childhood Cancer Survivor Study (BCCSS).

Methods
Late mortality was assessed among 49 822 5-year survivors of childhood cancer diagnosed before 15 years of age from 1970 to 1999 (CCSS, n = 31 596; BCCSS, n = 18 226) using cumulative mortality probabilities (CM%) and adjusted ratios of the standardized mortality ratio.

Results
The all-cause CM% at 10 years from diagnosis was statistically significantly lower in the CCSS (4.7%, 95% confidence interval [CI] = 4.5% to 5.0%) compared with the BCCSS (6.9%, 95% CI = 6.5% to 7.2%), attributable to a lower probability of death from recurrence or progression of the primary cancer, with statistically significant differences observed in survivors of leukemia, lymphoma, central nervous system tumors, and sarcoma. However, at 40 years from diagnosis, the CCSS had a greater CM% (22.3% vs 19.3%), attributable to a twofold higher risk of mortality from subsequent malignant neoplasms, cardiac and respiratory diseases, and other health-related causes. Differences increased when assessed by follow-up interval, with the CCSS faring worse as time-since-diagnosis increased. Finally, the gap in all-cause mortality widened more recently, with CCSS survivors diagnosed in 1990-1999 experiencing one-half the excess deaths observed in the BCCSS (ratios of the standardized mortality ratio = 0.5, 95% CI = 0.5 to 0.6).

Conclusions
Our findings suggest that US survivors may have received more intensive regimens to achieve sustainable remission and cure, but the cost of this approach was a higher risk of death from late effects. Although the clinical impact of these differences is unclear, our results provide important evidence to aid the discussion of late effects management.
Breast Cancer Mortality Hot Spots Among Black Women With de Novo Metastatic Breast Cancer
Authors: Han Yunan , Langston Marvin , Fuzzell Lindsay , Khan Saira , Lewis-Thames Marquita W , Colditz Graham A , Moore Justin Xavier 
Published: September 2020

Abstract

Background
Black women living in southern states have the highest breast cancer mortality rate in the United States. The prognosis of de novo metastatic breast cancer is poor. Given these mortality rates, we are the first to link nationally representative data on breast cancer mortality hot spots (counties with high breast cancer mortality rates) with cancer mortality data in the United States and investigate the association of geographic breast cancer mortality hot spots with de novo metastatic breast cancer mortality among Black women.

Methods
We identified 7292 Black women diagnosed with de novo metastatic breast cancer in Surveillance, Epidemiology, and End Results (SEER). The county-level characteristics were obtained from 2014 County Health Rankings and linked to SEER. We used Cox proportional hazards models to calculate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for mortality between hot spot and non–hot spot counties.

Results
Among 7292 patients, 393 (5.4%) resided in breast cancer mortality hot spots. Women residing in hot spots had similar risks of breast cancer–specific mortality (aHR = 0.99, 95% CI = 0.85 to 1.15) and all-cause mortality (aHR = 0.97, 95% CI = 0.84 to 1.11) as women in non–hot spots after adjusting for individual and tumor-level factors and treatments. Additional adjustment for county-level characteristics did not impact mortality.

Conclusion
Living in a breast cancer mortality hot spot was not associated with de novo metastatic breast cancer mortality among Black women. Future research should begin to examine variation in both individual and population-level determinants, as well as in molecular and genetic determinants that underlie the aggressive nature of de novo metastatic breast cancer.
To Belabour The Points: Encoding Vowel Phonology in Syriac and Hebrew Vocalization
Authors: Posegay Nick 
Published: September 2020

Abstract
Medieval Hebrew and Syriac scribes both indicated vowels by placing dots above or below their consonantal writing. These vowel points were created in the Late Antique and early Islamic periods to disam-biguate the vocalization of important texts, especially the Bible. The earliest step in this process was the implementation of the Syriac ‘diacritic dot’ system, which used a single dot to distinguish pairs of homographs: a dot ‘above’ marked a word with relatively-backed vowels, and a dot ‘below’ marked its homograph with relatively-fronted vowels. This graphic depiction conveyed a phonological association of ‘height’ with ‘backness’, and that association then entered the Maso-retic Hebrew tradition in the form of mille'el (‘above’) and millera' (‘below’) homograph comparisons. In turn, this principle of backness as ‘height’ informed the later placement of both the Syriac and the Tiberian Hebrew vowel points.1
Family Formations in Contemporary South Africa: Does South African Marriage Law Protect Lived Realities?
Authors: Osman Fatima 
Published: September 2020

Abstract
In the 21st century, families are constituted differently to the typical Western Judeo-Christian nuclear family comprising of a mother, father, and children. While some individuals may marry, others may choose not to do so or, at the other end of the spectrum, marry several individuals. This article critically examines whether South African marriage law adequately protects contemporary family formations. The examination reveals that unfortunately – but perhaps not unsurprisingly – the heteronormative nuclear family continues to be positioned as the baseline for the conferral of rights with opposite-sex civil marriages often receiving the greatest protection in South African law. Despite the legislative recognition of civil unions and customary marriages, the realisation of rights by individuals in these fringe groups is hindered by the creation of a complex legislative framework and practical difficulties encountered in the implementation of the law. Furthermore, notwithstanding years of legislative deliberation on the matter, unmarried partners and those in religious marriages enjoy only ad hoc protection through case law and piecemeal legislative provisions. While judicial activism in this arena may be lauded, the limited nature of judgments has led to continuous litigation for the realisation of rights. Statutory reform is thus required to ensure the equal treatment of all marriages, reconcile and simplify existing statutory law, address practical difficulties in the implementation of the law, and govern social reality.
Equilibrium models of the Milky Way mass are biased high by the LMC
Authors: Erkal Denis , Belokurov Vasily A , Parkin Daniel L 
Published: September 2020

ABSTRACT
Recent measurements suggest that the Large Magellanic Cloud (LMC) may weigh as much as 25 per cent of the Milky Way (MW). In this work, we explore how such a large satellite affects mass estimates of the MW based on equilibrium modelling of the stellar halo or other tracers. In particular, we show that if the LMC is ignored, the MW mass within 200 kpc is overestimated by as much as 50 per cent. This bias is due to the bulk motion in the outskirts of the Galaxy’s halo and can be, at least in part, accounted for with a simple modification to the equilibrium modelling. Finally, we show that the LMC has a substantial effect on the orbit Leo I which acts to increase its present-day speed relative to the MW. We estimate that accounting for a $1.5\times 10^{11} \, \mathrm{M}_\odot$ LMC would lower the inferred MW mass to $\sim 10^{12} \, \mathrm{M}_\odot$.
NICER observations reveal that the X-ray transient MAXI J1348−630 is a black hole X-ray binary
Authors: Zhang L , Altamirano D , Cúneo V A , Alabarta K , Enoto T , Homan J , Remillard R A , Uttley P , Vincentelli F M , Arzoumanian Z , Bult P , Gendreau K C , Markwardt C , Sanna A , Strohmayer T E , Steiner J F , Basak A , Neilsen J , Tombesi F 
Published: September 2020

ABSTRACT
We studied the outburst evolution and timing properties of the recently discovered X-ray transient MAXI J1348−630 as observed with NICER. We produced the fundamental diagrams commonly used to trace the spectral evolution, and power density spectra to study the fast X-ray variability. The main outburst evolution of MAXI J1348−630 is similar to that commonly observed in black hole transients. The source evolved from the hard state (HS), through hard- and soft-intermediate states, into the soft state in the outburst rise, and back to the HS in reverse during the outburst decay. At the end of the outburst, MAXI J1348−630 underwent two reflares with peak fluxes approximately one and two orders of magnitude fainter than the main outburst, respectively. During the reflares, the source remained in the HS only, without undergoing any state transitions, which is similar to the so-called ‘failed outbursts’. Different types of quasi-periodic oscillations (QPOs) are observed at different phases of the outburst. Based on our spectral-timing results, we conclude that MAXI J1348−630 is a black hole candidate.
ZFAT binds to centromeres to control noncoding RNA transcription through the KAT2B–H4K8ac–BRD4 axis
Authors: Ishikura Shuhei , Nakabayashi Kazuhiko , Nagai Masayoshi , Tsunoda Toshiyuki , Shirasawa Senji 
Published: September 2020

Abstract
Centromeres are genomic regions essential for faithful chromosome segregation. Transcription of noncoding RNA (ncRNA) at centromeres is important for their formation and functions. Here, we report the molecular mechanism by which the transcriptional regulator ZFAT controls the centromeric ncRNA transcription in human and mouse cells. Chromatin immunoprecipitation with high-throughput sequencing analysis shows that ZFAT binds to centromere regions at every chromosome. We find a specific 8-bp DNA sequence for the ZFAT-binding motif that is highly conserved and widely distributed at whole centromere regions of every chromosome. Overexpression of ZFAT increases the centromeric ncRNA levels at specific chromosomes, whereas its silencing reduces them, indicating crucial roles of ZFAT in centromeric transcription. Overexpression of ZFAT increases the centromeric levels of both the histone acetyltransferase KAT2B and the acetylation at the lysine 8 in histone H4 (H4K8ac). siRNA-mediated knockdown of KAT2B inhibits the overexpressed ZFAT-induced increase in centromeric H4K8ac levels, suggesting that ZFAT recruits KAT2B to centromeres to induce H4K8ac. Furthermore, overexpressed ZFAT recruits the bromodomain-containing protein BRD4 to centromeres through KAT2B-mediated H4K8ac, leading to RNA polymerase II-dependent ncRNA transcription. Thus, ZFAT binds to centromeres to control ncRNA transcription through the KAT2B–H4K8ac–BRD4 axis.
Single-nucleotide polymorphism of the DNA cytosine deaminase APOBEC3H haplotype I leads to enzyme destabilization and correlates with lung cancer
Authors: Hix Mark A , Wong Lai , Flath Ben , Chelico Linda , Cisneros G Andrés 
Published: September 2020

Abstract
A number of APOBEC family DNA cytosine deaminases can induce mutations in tumor cells. APOBEC3H haplotype I is one of the deaminases that has been proposed to cause mutations in lung cancer. Here, we confirmed that APOBEC3H haplotype I can cause uracil-induced DNA damage in lung cancer cells that results in γH2AX foci. Interestingly, the database of cancer biomarkers in DNA repair genes (DNArCdb) identified a single-nucleotide polymorphism (rs139298) of APOBEC3H haplotype I that is involved in lung cancer. While we thought this may increase the activity of APOBEC3H haplotype I, instead we found through computational modeling and cell-based experiments that this single-nucleotide polymorphism causes the destabilization of APOBEC3H Haplotype I. Computational analysis suggests that the resulting K121E change affects the structure of APOBEC3H leading to active site disruption and destabilization of the RNA-mediated dimer interface. A K117E mutation in a K121E background stabilized the APOBEC3H haplotype I, thus enabling biochemical study. Subsequent analysis showed that K121E affected catalytic activity, single-stranded DNA binding and oligomerization on single-stranded DNA. The destabilization of a DNA mutator associated with lung cancer supports the model that too much APOBEC3-induced mutation could result in immune recognition or death of tumor cells.