bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mixing studies for lupus anticoagulant: mostly yes, sometimes no
Authors: Favaloro Emmanuel 
Published: December 2019

Abstract
Lupus anticoagulants (LAs) represent one manifestation of the clinical condition called antiphospholipid syndrome (APS) and are associated with many adverse clinical outcomes, but primarily with thrombosis and/or pregnancy morbidity. LAs are identified by laboratory testing, principally using clot-based assays based on Russell viper venom time (RVVT) and activated partial thromboplastin time (APTT) test methods. All three of the most recent guidance documents for LA testing recommend using these tests, although they vary in regard to inclusion/exclusion of other test processes. Mixing studies form part of the process of LA identification/exclusion, since in vitro LAs act like coagulation inhibitors. Mixing studies are also supported by all three LA guidance documents, but recommendations vary in regard to relative importance and placement in the LA identification/exclusion algorithm. This Point article takes the position that mixing tests are usually indicated for appropriate identification/exclusion of LAs, but can occasionally be omitted.
Synthesis And Characterization Of CoMo/Mordenite Catalyst For Hydrotreatment Of Lignin Compound Models
Authors: Nugrahaningtyas Khoirina Dwi , Rahmawati Nining , Rahmawati Fitria , Hidayat Yuniawan 
Published: December 2019

AbstractThe synthesis of CoMo/Mordenite (CoMo/MOR) catalysts was conducted using a co-impregnation method at a various Co/Mo ratios. The produced catalysts were then characterized by X-ray diffraction, total acidity analysis, and scanning electron microscopy. The activity of the catalyst in a hydrotreatment reaction was evaluated by applying the catalyst as a reduced-catalyst to the hydrocracking (HC) reaction of anisole molecules. Analysis of the diffraction data using the Le Bail refinement technique showed that the metal phase was successfully impregnated into the MOR. In addition, increasing the metal content resulted in an increase in the acidity of the catalysts and changed the morphology of the catalysts from homogeneous to heterogeneous with larger particle size. According to the data of GCMS, it is known that the catalysts successfully removed methyl group of anisole molecules. Hydrotreatment reaction with the prepared-catalyst produced 4.77% of phenols. It is 122 % higher than the reaction with MOR catalyst.
Heat Transfer Performance of Vertical Tube Falling Film Juice Evaporator and a Sensitivity Analysis
Authors: Song Jitian , Su Hang , Tian Wei , Wang Yening , Feng Yongxia , Liu Jianbo 
Published: December 2019

Abstract
Fresh fruit juice has a short storage period and it usually needs to be concentrated for shelf-life extension. Evaporation of fruit juice is an attractive method and vertical tube falling film evaporator is one of good choice. The main problem in the design of the evaporator is the reliable estimation of the heat transfer coefficient for all effects. In this paper, the effects of feed flow rate, evaporation temperature, temperature difference, and juice soluble solid content on heat transfer coefficient of a vertical falling film evaporator were investigated. The Bayesian treed Gaussian process model was used to identify the key variables affecting the heat transfer coefficient, which showed that evaporation temperature had the greatest influence on the sensitivity of heat transfer coefficient. It also demonstrated that complex interactions existed between the four operating parameters had a significant effect on the overall heat transfer coefficient.
Exploring Faculty Perceptions about Simulation Training: Influence on Career, Confidence, Knowledge and Skill Acquisition and Competence
Authors: Waxman KT , Nichols Amy A. , Shum Cynthia , Forsey Lynn 
Published: December 2019

Abstract
Even with insufficient evidence in the literature regarding the impact of faculty development with simulation education, faculty development is critical to building a successful simulation program. Despite simulation being ubiquitous in nursing education across the United States (US), there is little investigation of the impact of the education and training on job satisfaction, skill development and overall confidence when using simulation to teach nursing students. The purpose of this qualitative study was to investigate how has simulation education and training has influenced faculty career fulfillment, acquisition of knowledge, overall self-confidence and competence? Themes that emerged included the following: competency, professional role change, role acquisition, course learner needs, course impact, skill development, and overall ability and confidence. The study results confirmed that a gap exists where faculty without formal education may not be aware of their lack of competence and what training they need to be effective in facilitating clinical simulation.
Impact of Socio-Emotional Skills On The Performance of Clinical Nursing Practices
Authors: Sánchez Expósito Judit , Jiménez-Rodríguez Diana , Díaz Agea José Luis , Carrillo Izquierdo María Dolores , Leal Costa Cesar 
Published: December 2019

Abstract

Aim
To analyze the Socio-emotional (SE) skills of the students in the Nursing Degree, and their relationship with their clinical practice in hospital centers.

Methods
Cross-sectional descriptive study of a sample of 91 nursing students. SE skills were analyzed through self-administered questionnaires, and the clinical practices through the instrument “Clinical Practices Evaluation Notebook”.

Findings
The students obtained medium and high scores in the SE skills and in the clinical practices. Most of the SE skills had a positive and statistically significant relationship (p < 0.05) between them. A relationship was observed between SE skills with performance in clinical practices, through a multiple linear regression.

Discussion
It is suggested that the development of the SE skills of the nursing students within the Nursing degree curriculum has an influence on their performance during their clinical practices.

Conclusion
The SE skills are a potential predictor of the performance of the nursing students in clinical practices.
Mental Imagery and Strength Training: Student Athletes’ Perceptions, Desires, and the Impact of Psychoeducation
Authors: Wallace Alex Francis Xavier , Blom Lindsey C. , Gretton Thomas W. 
Published: December 2019

Abstract
Consistent evidence suggests the effectiveness of mental imagery (MI) for improving strength training performance (STP). However, strength and conditioning (S&C) coaches infrequently encourage use of MI, potentially believing athletes perceive it to be ineffective in supporting STP Additionally, psychoeducation has been found to affect perceptions regarding information presented. The purpose of this study was to assess the perceptions and desires of athletes regarding the effectiveness and use of MI to support STP. The impact of an animated psychoeducation video on perceptions of effectiveness and desires to learn more about MI for STP was assessed as well. 47 NCAA Division I student athletes (various sports; female: n = 34) participated in the pre-post study. Participants’ use of MI, S&C coaches’ encouragement of MI, perceptions of MI effectiveness on STP, and interest in learning more about MI to support STP were initially assessed. Following a two-minute video, participants’ perceptions of MI effectiveness on STP and interest in learning more about MI to support STP were reassessed. Significant increases were found in participants’ perceptions of MI effectiveness to support STP (p < 0.05). No significant changes were noticed regarding athletes’ desires to learn more about MI to support STP. Although potentially uninterested in learning more about MI, student athletes indeed perceive MI to be effective, especially after provided with information. Encouragement of MI by S&C coaches to their student athletes is warranted.
Sincerity in Lithuanian epistolarity: Between truth and emotion
Authors: Tamošiūnaitė Aurelija 
Published: December 2019

AbstractThis paper investigates the lexical representation of sincerity in Lithuanian epistolarity throughout the twentieth century. Drawing on data from the corpus of Lithuanian letters and employing the techniques of corpus, statistical and philological analysis, this paper explores the use, frequency and context of occurrence of the four sets of lexical stems:atvir- (‘open’, ‘frank’),nuošird- (‘sincere’, ‘honest’),šird- (‘heart’), andtikr- (‘authentic’, ‘genuine’, ‘real’). As each of these lexical stems foreground different semantic shades of sincerity, they are treated in this paper as lexical variables that inscribe different degrees of an author’s sincere attitude (stance) toward the addressee and the writing act itself. The findings suggest that in Lithuanian epistolarity the use of sincerity lexemes is constrained by the grammatical shape of the lexeme and genre-related factors, namely, formulaic vs. non-formulaic context. Frequent lexical inscription of sincerity lexemes in the speech acts of thanking, wishing and greeting suggests that sincerity (as a stance) is conventionally linked to these specific social acts. When these social acts are evoked in epistolary practice, they thus evoke a particular (sincere) stance meaning.
Magnons scattering induced photonic chaos in the optomagnonic resonators
Authors: Gao Yong-Pan , Cao Cong , Duan Yu-Wen , Liu Xiao-Fei , Pang Ting-Tian , Wang Tie-Jun , Wang Chuan 
Published: December 2019

Abstract
Along with the studies of the properties of optical microcavities, the optical nonlinear effects of the material and the interaction between light and matter are becoming important topics. For example, the chaotic effect of the optical field may appear under the strong laser pumping due to the nonlinear effects. In this study, the chaotic phenomenon of photonic superposed states is investigated in an optomagnonical cavity. Through the dynamic evolution of two-mode photons in the cavity, we found that the energy of the system could be transferred between different modes, and the chaotic behaviour can be tuned by the coupling and the dissipation.
Pemetrexed versus Gefitinib as Second-line Treatment for Advanced Non-small Cell Lung Cancer: A Meta-analysis Based on Randomized Controlled Trials
Authors: Wang Huiyu , Zhang Zunjing , Liu Feng , Zhou Miaoying , Lv Handi 
Published: December 2019

Abstract

Objective To investigate the clinical efficacy and toxicity of Pemetrexed versus Gefitinib as second-line treatment for advanced non-small cell lung cancer (NSCLC).

Methods By systematically searching the electronic databases of Pubmed, CENTRAL, Cochrane, EMBASE, ASCO, and CBM, open published randomized clinical trials (RCTs) relevant to clinical efficacy and toxicity of Pemetrexed versus Gefitinib as second-line treatment of advanced NSCLC were included in the meta-analysis. Data of objective response rate (ORR) and drug related toxicity were extracted from the original publications and pooled by random or fixed effect method.

Results Fourteen clinical trials related to Pemetrexed versus Gefitinib as second-line treatment for advanced NSCLC fulfilled the inclusion criteria and were included in the meta-analysis. The pooled results show that the ORR (RR=0.81, 95% CI:0.56–1.16, p=0.25) and DCR (RR=1.11, 95% CI:0.94–1.31, p=0.24) were not statistical different for Pemetrexed versus Gefitinib as second-line treatment of advanced NSCLC. However, the pooled data demonstrated the risk of developing skin rash (RR=0.10, 95% CI:0.03–0.30, p=0.00) and diarrhea (RR=0.31, 95% CI:0.15–0.67, p=0.003) in patients with Pemetrexed was significantly lower than that of Gefitinib through random effect model analysis, but the incidence of neutropenia in Pemetrexed group was significantly higher than that of Gefitinib with statistical difference (RR=7.62, 95% CI:3.71–15.66, p=0.00).

Conclusion Pemetrexed was not inferior as second-line treatment for advanced NSCLC compared to Gefitinib for tumor response. However, Pemetrexed had higher incidence of neutropenia but lower risk of developing skin rash and diarrhea.
Capital californiano, necesidad presupuestal y cambio político: Juan Temple y el arrendamiento de la Casa de Moneda de México, 1827–1857
Authors: Herrera Omar Velasco 
Published: December 2019

Durante la primera mitad del siglo xix, las necesidades presupuestales del erario mexicano obligaron al gobierno a recurrir al endeudamiento y al arrendamiento de algunas de las casas de moneda más importantes del país. Este artículo examina las condiciones políticas y económicas que hicieron posible el relevo del capital británico por el estadounidense—en estricto sentido, californiano—como arrendatario de la Casa de Moneda de México en 1857. Asimismo, explora el desarrollo empresarial de Juan Temple para explicar la coyuntura política que hizo posible su llegada, y la de sus descendientes, a la administración de la ceca de la capital mexicana.
During the first half of the nineteenth century, the budgetary needs of the Mexican treasury forced the government to resort to borrowing and leasing some of the most important mints in the country. This article examines the political and economic conditions that allowed for the replacement of British capital by United States capital—specifically, Californian—as the lessee of the Mexican National Mint in 1857. It also explores the development of Juan Temple’s entrepreneurship to explain the political circumstances that facilitated his admission, and that of his descendants, into the administration of the National Mint in Mexico City.
TBK1‐mediated phosphorylation of LC3C and GABARAP‐L2 controls autophagosome shedding by ATG4 protease
Authors: Herhaus Lina , Bhaskara Ramachandra M , Lystad Alf Håkon , Gestal‐Mato Uxía , Covarrubias‐Pinto Adriana , Bonn Florian , Simonsen Anne , Hummer Gerhard , Dikic Ivan 
Published: December 2019

AbstractAutophagy is a highly conserved catabolic process through which defective or otherwise harmful cellular components are targeted for degradation via the lysosomal route. Regulatory pathways, involving post‐translational modifications such as phosphorylation, play a critical role in controlling this tightly orchestrated process. Here, we demonstrate that TBK1 regulates autophagy by phosphorylating autophagy modifiers LC3C and GABARAP‐L2 on surface‐exposed serine residues (LC3C S93 and S96; GABARAP‐L2 S87 and S88). This phosphorylation event impedes their binding to the processing enzyme ATG4 by destabilizing the complex. Phosphorylated LC3C/GABARAP‐L2 cannot be removed from liposomes by ATG4 and are thus protected from ATG4‐mediated premature removal from nascent autophagosomes. This ensures a steady coat of lipidated LC3C/GABARAP‐L2 throughout the early steps in autophagosome formation and aids in maintaining a unidirectional flow of the autophagosome to the lysosome. Taken together, we present a new regulatory mechanism of autophagy, which influences the conjugation and de‐conjugation of LC3C and GABARAP‐L2 to autophagosomes by TBK1‐mediated phosphorylation.
Natural Sources of Spraying to Preserve Apple Fruit Quality during Post-Harvest
Authors: ACEVEDO-BARRERA Angelica A. , SOTO PARRA Juan M. , YAÑEZ-MUÑOZ Rosa M. , SANCHEZ Esteban , PEREZ-LEAL Ramona 
Published: December 2019

One of the great challenges that apple producers face is to substantially improve the quality of fruit, including after harvest. A balanced and timely supply of calcium (Ca) during growth and in the post-harvest stage is considered a technique that could improve shelf life and fruit quality; thus calcium plays a key role during post-harvest, with calcium carbonate and calcium sulphate being an alternative of foliar spraying. The study was carried out on ‘Top Red’ and ‘Golden Delicious’ apple cultivars, in a randomized complete block design with 13 treatments (referring to different commercial presentations of calcium) and 6 repetitions; 8 foliar sprays were applied weekly, from June 22 until harvest; ‘Top Red’ (151 days after full flowering, DDCF) and ‘Golden Delicious’ (145 DDCF) fruit were evaluated in regard with fruit traits (diameter, weight and colour) and maturity (pulp firmness, total soluble solids, titratable acidity and sugar acidity ratio). In ‘Top Red’ cv., calcium carbonate presented the best results, with intermediate to high quality apple fruit, while for cv. ‘Golden Delicious’ the best results were obtained with calcium sulphate, which increased fruits’ diameter, weight, colour and titratable acidity. Even more, of the products evaluated, CaCO3 and CaSO4 had the lowest costs, and can be considered as good alternatives of foliar calcium supplement applied in order to preserve the quality of the apple during post-harvest.

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In press - Online First. Article has been peer reviewed, accepted for publication and published online without pagination. It will receive pagination when the issue will be ready for publishing as a complete number (Volume 47, Issue 4, 2019). The article is searchable and citable by Digital Object Identifier (DOI). DOI link will become active after the article will be included in the complete issue.
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Effect of Sunny and Half-shaded Sites on the Growth of Plants and Anthocyanin Pigments Content in Leaves of Heuchera L. ‘Mysteria’ and ‘Peppermint Spice’ Cultivars
Authors: JANOWSKA Beata , CZUCHAJ Piotr K. , KUBIŚ Jan , RYBUS-ZAJĄC Magdalena , KOKOCIŃSKA Daniela 
Published: December 2019

Two cultivars of Heuchera L. - ‘Mysteria’ and ‘Peppermint Spice’ were grown in a collection at a sunny site and a slightly shaded one. The access of sunlight was limited by shade nets, which were stretched on wooden scaffolding over the plants. The dynamics of growth of the plants in the sunny and half-shaded sites was assessed in the growth periods, in two consecutive years. After the second year, the content of anthocyanins in the leaves of different physiological maturity (young, mature and fully mature) was measured. Apart from August, during the whole growth period both cultivars formed more leaves during the first year of cultivation. Both the ‘Mysteria’ and ‘Peppermint Spice’ cultivars formed more leaves at the sunny site. The research showed that the highest content of anthocyanins in the Heuchera ‘Mysteria’ and ‘Peppermint Spice’ cultivars growing at the sunny and half-shaded sites was found in young leaves, whereas the lowest content was noted in fully mature leaves. The highest content of anthocyanins in both Heuchera cultivars was found at the initial growth period, i.e. between May and July, when the light intensity was the greatest, regardless of the place of cultivation. At the end of the growth period, the biosynthesis of anthocyanins decreased significantly. Anthocyanins accumulated in the vacuole are able to play a role as the screening pigments under intensive PAR and UV-B radiation.

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In press - Online First. Article has been peer reviewed, accepted for publication and published online without pagination. It will receive pagination when the issue will be ready for publishing as a complete number (Volume 47, Issue 4, 2019). The article is searchable and citable by Digital Object Identifier (DOI). DOI link will become active after the article will be included in the complete issue.
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Assessment of Genetic Diversity of an Endangered Species Fraxinus hupehensis Based on ISSR Markers
Authors: ZHENG Peng-Li , CHENG Jian-Ru , CHEN Long-Qing , ZHOU Ming-Qin 
Published: December 2019

Investigation on the level and pattern of genetic diversity of 10 natural populations of the endangered species Fraxinus hupehensis using inter-simple sequence repeat (ISSR) markers was crucial for understanding the structure of the population and assessing the best genetic protection strategies. A total of 180 polymorphic bands with the polymorphic rate of 100.00% were amplified by 14 primers. The genetic diversity at population level (Percentage of polymorphic loci, PPL=64.06; Nei’s gene diversity index, h=0.1519; Shannon’s information index, I=0.2434) was lower than that at species level (PPL= 100.00%, h=0.1833, I=0.3041). Analysis of molecular variance (AMOVA) demonstrated the low level of the genetic variation occurred between the populations (16.05%). This also can be corroborated by the gene flow (Nm 2.424) and the coefficient of gene differentiation (Gst=0.1710) among populations. Cluster analysis based on the unweighted pair group method with arithmetic averages (UPGMA) revealed four groups for 10 populations according to Nei’s genetic identity and seven categories for the 196 individuals according to SM values. Furthermore, the endangered mechanism and genetic structure of F. hupehensis were discussed, and appropriate targeted protection measures were proposed based on these findings.

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In press - Online First. Article has been peer reviewed, accepted for publication and published online without pagination. It will receive pagination when the issue will be ready for publishing as a complete number (Volume 47, Issue 4, 2019). The article is searchable and citable by Digital Object Identifier (DOI). DOI link will become active after the article will be included in the complete issue.
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Introduction pages
Authors: SESTRAS Radu E. 
Published: December 2019

Notulae Botanicae Horti Agrobotanici Cluj-Napoca (NBHA), Issue 4, Volume 47, 2019: The papers published in this issue Vol 47 No 4 (2019) represent new exciting researches in different topics of life science, respectively in plant science, horticulture, agronomy and crop science. Among the interesting articles we invite you to find news about the allelopathic potential of leaf extracts from Dischidia imbricate; quinoa (Chenopodium quinoa) growth in response to fertilization and soil tillage; drought avoidance and phenotypic flexibility of sweet potato (Ipomoea batatas) under water scarcity conditions; development of an efficient ‘one-step freezing’ cryopreservation protocol for a Georgian provenance of chestnut (Castanea sativa) zygotic embryos; effect of nitrogen fertiliser and lime on the floristic composition, soil microbes and dry matter yield of Danthonietum calycinae grassland; screening for salt and water stress tolerance in fir (Abies alba) populations; somatic embryogenesis induction in leaf and root explants of Allophylus edulis; spatial distribution of glomalin-related soil proteins in coniferous and broadleaf mixed temperate forest etc. Notulae Botanicae Horti Agrobotanici Cluj-Napoca journal has moved to online-only publication at the start of 2017; beginning in 2019, the journal appears quarterly. At the same time, we maintain our standard publication, as printed form, with ‘classic’ style - volume, issue, pagination.
Prácticas Parentales e Inteligencia Emocional en Estudiantes de Secundaria. Un Estudio Correlacional.
Authors: Fragoso Luzuriaga Rocio , Juarez Flores José Fernando 
Published: December 2019

La familia tiene una influencia determinante en el desarrollo de habilidades socioemocionales, como la Inteligencia Emocional (IE), en niños y adolescentes. Sin embargo, actualmente existen pocos estudios empíricos que ayuden a profundizar en la temática. Por lo anterior, la presente investigación tuvo como objetivo determinar las correlaciones existentes entre la IE y las Practicas Parentales percibidas por estudiantes de 2º año de la Secundaria Técnica Número 96 de la ciudad de Puebla. Para lograr dicho propósito se aplicó el TMMS-24 junto con la Escala de Prácticas Parentales para Adolescentes de Andrade Palos y Betancourt Ocampo (2008) a 196 jóvenes entre los 13 y 15 años de edad. Posteriormente, al analizar los resultados de ambos instrumentos, se encontró que las prácticas parentales de autonomía, comunicación y control conductual se correlacionan positivamente con la IE en tanto que las prácticas parentales de control psicológico se correlacionan negativamente con la IE.