bluuebunny/crossref_metadata_2025_split huggingface dataset:
Melt fracture and wall slip of thermoplastic vulcanizates
Authors: Ghahramani Nikoo , Zhang Shiling , A. Iyer Krishnan , Doufas Antonios K. , Hatzikiriakos Savvas G. 
Published: November 2020

AbstractThermoplastic vulcanizates (TPVs) are blends of polypropylene (PP) (thermoplastic phase) and ethylene propylene diene monomer (EPDM) rubber (rubber phase) in which a high content of rubber EPDM is cross‐linked and dispersed in a thermoplastic matrix (PP) in the presence of oil (lubricant) and filler. Depending on the molecular characteristics of the constituent polymers, the level of curing and the amount of cross‐linked rubber, their processing (extrusion) exhibits various difficulties such as melt fracture (extrudate distortions). In this study, a number of different TPVs with various characteristics, including the degree of curing and amount of cross‐linked rubber are examined in capillary extrusion at two different temperatures (190°C and 205°C) relevant to real processing. First, the effect of the temperature on the yield stress is investigated using rheological measurements. Consequently, the flow behavior of the TPVs in capillary flow is studied concluding that TPVs slip massively (nearly plug flow) due to the presence of lubricant and the vulcanized rubber phase. Although there is little slip observed in PP samples, EPDMs themselves exhibit severe slip and melt fracture. As a consequence, the TPV samples essentially follow the slip behavior of EPDMs. Finally, the melt fracture analysis of several TPVs has shown that with increase of temperature and amount of cross‐linked rubber, the severity of TPVs' surface defects increases accordingly.
Are granulins copper sequestering proteins?
Authors: Bhopatkar Anukool A. , Rangachari Vijayaraghavan 
Published: November 2020

AbstractGranulins (GRN 1‐7) are short (~6 kDa), cysteine‐rich proteins that are generated upon the proteolytic processing of progranulin (PGRN). These peptides, along with their precursor, have been implicated in multiple pathophysiological roles, especially in neurodegenerative diseases. Previously we showed that GRN‐3 and GRN‐5 are fully disordered in the reduced form implicating redox sensitive attributes to the proteins. Redox‐based modulations are often carried out by metalloproteins in mitigating oxidative stress and maintaining metal‐homeostasis within cells. To probe whether GRNs play a role in metal sequestration, we tested the metal binding propensity of the reduced forms of GRNs −3 and − 5 under neutral and acidic pH mimicking cytosolic and lysosomal conditions, respectively. We found, at neutral pH, both GRNs selectively bind Cu and no other divalent metal cations, with a greater specificity for Cu(I). Binding of Cu did not result in a disorder‐to‐order structural transition but partly triggered the multimerization of GRNs via uncoordinated cystines at both pH conditions. Overall, the results indicate that GRNs −3 and − 5 have surprisingly strong affinity for Cu in the pM range, comparable to other known copper sequestering proteins. The results also hint at a potential of GRNs to reduce Cu(II) to Cu(I), a process that has significance in mitigating Cu‐induced ROS cytotoxicity in cells. Together, this report uncovers metal‐coordinating property of GRNs for the first time, which may have profound significance in their structure and pathophysiological functions.
Kinetics and degradation mechanism of atmospheric isoprene (2‐methyl‐1, 3‐butadiene (C5H8)) with chlorine radical and its derivatives—A theoretical study
Authors: Subramani Mohanapriya , Rajamani Akilan , Shankar Ramasamy 
Published: November 2020

AbstractIsoprene (2‐methyl‐1, 3‐butadiene (C5H8)) is one of the most prominent and abundant non‐methane hydrocarbon existing in the lower level of the troposphere. In this work, possible reaction mechanism of chlorine (Cl) radical initiated isoprene and its subsequent reactions are investigated using quantum chemical methods at M06‐2X/CCSD(T)/6‐311+G* level of theory. The calculated thermodynamic result shows that the reaction of isoprene with the Cl radical at the terminal CC bond position plays an important role to predict the end products. The calculated rate coefficient for the reaction between isoprene and Cl radicals (Cl addition at C1, C3, C4 and C5 positions) is found to be 4.89 × 10−11, 6.91 × 10−10, 1.63 × 10−10 and 8.12 × 10−10 cm3/molecule/s at 298 K. The branching ratio and atmospheric lifetime have been calculated from the reaction rate coefficient values of isoprene + Cl. The reaction force analysis predicts Cl radical addition at the terminal CC bond position plays a dominant role by structural rearrangement. The kinetic and thermodynamic results reveal that the electrophilic addition of Cl radical to the terminal carbon atom plays the dominant role in the marine boundary. Further, the subsequent reaction of Cl‐isoprene adduct radical helps for the development of ozone layer during daytime.
Ultrathin Single‐Crystalline 2D Perovskite Photoconductor for High‐Performance Narrowband and Wide Linear Dynamic Range Photodetection
Authors: Tu Yudi , Xu Yan , Li Junzi , Hao Qiaoyan , Liu Xiaosong , Qi Dianyu , Bao Chunxiong , He Tingchao , Gao Feng , Zhang Wenjing 
Published: November 2020

AbstractFor next‐generation Internet‐of‐Everything applications, for example, artificial‐neural‐network image sensors, artificial retina, visible light communication, on‐chip light interconnection, and flexible devices, etc., high‐performance microscale photodetectors are in urgent demands. 2D material (2DM) photodetectors have been researched and demonstrated impressive performances. However, they have not met the demands in filterless narrowband photoresponse, wide linear dynamic range (LDR), ultralow dark current, and large on/off ratio, which are key performances for these applications. 2D Ruddlesden–Popper perovskites (2D‐RPPs) are recently highlighted photovoltaic and optoelectronic materials. Embedding ultrathin 2D‐RPPs into 2DM photodetectors holds potentials to improve these performances. Herein, a single‐crystalline ultrathin (PEA)2PbI4 is integrated into a vertical‐stacked graphene‐(PEA)2PbI4‐graphene micro photoconductor (V‐PEPI‐PC). V‐PEPI‐PC exhibits narrowband photoresponses at 517 nm with a full‐width‐at‐half‐maximum of 15 nm and a wide LDR of 122 dB. Due to the multiple quantum wells in (PEA)2PbI4, V‐PEPI‐PC demonstrates an ultralow dark current of 1.1 × 10−14 A (44 pA mm−2), a high specific detectivity of 1.2 × 1013 Jones, and a high on/off ratio of 1.6 × 106. Owing to the short vertical channel, V‐PEPI‐PC shows a fast response rise time of 486 µs. Therefore, the vertical‐stacked photodetectors based on hybrid 2D‐RPPs and 2DMs may have great potentials in future optoelectronics.
Efficient Water Splitting Actualized through an Electrochemistry‐Induced Hetero‐Structured Antiperovskite/(Oxy)Hydroxide Hybrid
Authors: She Sixuan , Zhu Yinlong , Tahini Hassan A. , Wu Xinhao , Guan Daqin , Chen Yu , Dai Jie , Chen Yubo , Tang Wanqi , Smith Sean C. , Wang Huanting , Zhou Wei , Shao Zongping 
Published: November 2020

AbstractExploring active, stable, and low‐cost bifunctional electrocatalysts for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) is crucial for water splitting technology associated with renewable energy storage in the form of hydrogen fuel. Here, a newly designed antiperovskite‐based hybrid composed of a conductive InNNi3 core and amorphous InNi(oxy)hydroxide shell is first reported as promising OER/HER bifunctional electrocatalyst. Prepared by a facile electrochemical oxidation strategy, such unique hybrid (denoted as EO‐InNNi3) exhibits excellent OER and HER activities in alkaline media, benefiting from the inherent high‐efficiency HER catalytic nature of InNNi3 antiperovskite and the promoting role of OER‐active InNi(oxy)hydroxide thin film, which is confirmed by theoretical simulations and in situ Raman studies. Moreover, an alkaline electrolyzer integrated EO‐InNNi3 as both anode and cathode delivers a low voltage of 1.64 V at 10 mA cm−2, while maintaining excellent durability. This work demonstrates the application of antiperovskite‐based materials in the field of overall water splitting and inspires insights into the development of advanced catalysts for various energy applications.
Synthesis and Characterization of Sodium Carboxymethyl Starch‐Graft Acrylamide/1‐Vinyl‐2‐Pyrrolidone Copolymers via Central Composite Design and Using as Filtration Loss Agent in Drilling Muds
Authors: Bai Xiaodong , Zhang Xuepeng , Xu Yuqian , Yong Xuemei 
Published: November 2020

AbstractA graft copolymer is synthesized with graft copolymerization of acrylamide (AM) and 1‐vinyl‐2‐pyrrolidone (NVP) grafting onto sodium carboxymethyl starch (CMS) via central composite design (CCD). The initiation system consists of potassium persulfate (KPS) and sodium hydrogen sulfite (SBS). The copolymer is confirmed by infrared spectroscopy, nuclear magnetic resonance hydrogen spectroscopy, scanning electron microscopy, thermogravimetric experiment, and elemental analysis. The rheological performance, filtration loss, cake thickness, and cake fictional coefficient of the drilling mud containing copolymer are evaluated. The results show that copolymers have ability to thicken and reduce filtration volume and have no obvious influence on the thickness and fictional coefficient of the mud cake. Response surface methodology (RSM) is exerted for variable evaluation and optimization. The results indicate that initiator concentration is the main contributing factor to decrease filtration volume and the optimum results are 1.5 wt% (initiator concentration), 1.82 (mole ratio of monomer to starch [AGU]), 66.02 °C (reaction temperature), 3.87 h (reaction time). The predicted value and the actual experimental value are 8.64 and 9 mL respectively with an error of 4.01%. The small error indicates that there is a small deviation between the actual and the predicted values, which also shows that the model is reasonable.
Interagency Relations and the EU Migration Crisis: Strengthening of Law Enforcement Through Agencification?
Authors: Loschi Chiara , Slominski Peter 
Published: November 2020

AbstractWhile scholarly literature on Frontex has mushroomed over the last decade, agency’s interaction with other EU Justice and Home Affairs (JHA) agencies has received less attention. It is the objective of this paper to analyse how the crisis has shaped the horizontal interactions between EU JHA agencies and ask whether these relations have either enhanced the law enforcement focus of EU JHA or, conversely, strengthened a human rights-promoting EU as a ‘Union of Values’. Empirically, the chapter assesses the relations of Frontex with other JHA-related agencies such as the European Asylum Support Office or the Fundamental Rights Agency before and after the 2015 migration crisis. We argue that despite an increased human rights sensitivity, the migration crisis has not substantially changed the border management approach of Frontex but rather consolidated law enforcement profile of interagency cooperation and led only to minor improvements of fundamental rights.
STEPPS (System Training of Emotional Predictability and Problem Solving) in einer vernetzten ambulanten Hilfe für Menschen mit Borderline Persönlichkeitsstörung
Authors: Rahn Ewald 
Published: November 2020

ZusammenfassungSTEPPS ist ein evidenzbasiertes Fertigkeitentraining für Menschen mit einer Borderline Persönlichkeitsstörung, das sich vor allem für eine langfristige ambulante Begleitung eignet. STEPPS ist ein Gruppenprogramm und dient als Ergänzung zu bereits bestehenden Hilfeformen, weil eine optimale Nutzung der vorhandenen Hilfen ein Ziel des Trainings ist. Das Programm umfasst eine Auseinandersetzung mit der Erkrankung, die Vermittlung von Fertigkeiten zum Umgang mit Emotionen und ein Verhaltenstraining zum Transfer der vermittelten Fertigkeiten. Das soziale Netz der Betroffenen wird einbezogen und eine nachhaltige Partizipation angestrebt. Damit dient das Programm auch der indizierten Prävention der ausgeprägten psychosozialen und gesundheitlichen Risiken der Erkrankung. Das Programm ist besonders für vernetzte Versorgungssysteme geeignet.
An Embodied Artistic Inquiry into Attachment-Oriented Therapeutic Relationships
Authors: Mamis Emma K. 
Published: November 2020

AbstractIn this study, I utilized an embodied artistic inquiry self-study to explore my experience of attachment in the therapeutic movement relationships (TMR) created as a dance/movement therapy intern at a psychiatric residential treatment center for children. The research was guided by three questions: How do I experience the TMR with children in a psychiatric residential treatment setting using attachment theory? How is my personal attachment style influencing and guiding the therapeutic relationship? How does my identification of salient moments relate to my own attachment style and aesthetic preference? Data were collected using journal entries that reflected on the researcher’s experience of attachment, saliency, and Tortora’s D.A.N.C.E. qualities of attachment (Clin Soc Work J 38(1):37–50, https://doi.org/10.1007/s10615-009-0254-9, 2010). I analyzed the data using discussion and Authentic Movement with a research consultant in order to synthesize and describe the experience of each salient moment. Repeated movements included grounded and unstable walking, changing of levels, core-distal movements, circling and carving arms, and recuperation. The themes that resulted from repeated movements and discussion with the research consultant include foundational movements, holding discomfort, connection to a specific client, and playfulness. These results reinforced the importance of stability and self-awareness for a therapist especially in relationship to how their movement and nonverbal preferences may have been learned from attachment relationships. Furthermore, results show the impact of saliency and the clinician’s aesthetic preference. In addition, the results reflected the strong relationship among nonverbal qualities of attachment and the TMR. These results suggested that qualities of attachment underlie the effectiveness of the TMR. Although limitations of the study prevented me from drawing correlative conclusions, the therapist may be able to strengthen the therapeutic relationship by targeting primary attachment models, and suggestions for further research are included.
Predictive role of HER2-status on the effectiveness of endocrine adjuvant treatment in postmenopausal breast cancer patients: a population-based cohort study
Authors: Schiza Aglaia , Mauri Davide , Fredriksson Irma , Anna-Karin Wennstig  , Valachis Antonios 
Published: November 2020

Abstract
Purpose
There are conflicting results on the potential role of HER2-status on the efficacy of aromatase inhibitors (AIs) and tamoxifen (TAM) in patients with hormone receptor (HR)-positive breast cancer (BC). The purpose of this population-based cohort study was to investigate the potential benefit of AIs compared to TAM as adjuvant therapy in postmenopausal BC patients by HER2-status in the era of modern therapy with HER2-blockade.

Methods
A population-based cohort study was performed including all postmenopausal women diagnosed with HR-positive BC without distant metastasis between 2007 and 2012 in three healthcare regions in Sweden. We analyzed the breast cancer-specific survival (BCSS) and overall survival (OS) in two distinct cohorts (HER2-negative, HER2-positive) based on the type of endocrine therapy (ET) used. A propensity score matching was performed separately in the HER2-negative and HER2-positive cohorts, respectively.

Results
After propensity score matching, 4368 patients with HER2-negative and 214 patients with HER2-positive BC were available for analysis. In the HER2-negative cohort, an improved BCSS [Hazard Ratio (HR): 0.51; 95% confidence interval (CI): 0.34–0.77, p value < 0.001] and a trend toward improved OS (HR: 0.66; 95% CI: 0.41–1.08, p value = 0.093) in favor of AI-based therapy was observed. In the HER2-positive cohort, no statistically significant difference between AI-based ET and TAM was found in terms of either BCSS or OS, although the direction of HR was similar as in the HER2-negative cohort (HR for BCSS: 0.84; 95% CI: 0.14–5.04, p = 0.849; HR for OS: 0.62; 95% CI: 0.10–3.38, p = 0.345).

Conclusion
Our study results, based on propensity-matched cohorts, did not support any predictive value of HER2-status on endocrine therapy in postmenopausal BC patients. AI-based ET remains the treatment of choice for postmenopausal BC patients with HR-positive disease in the modern era of HER2-directed therapy irrespective of HER2-status.
Myocardial contractility recovery following acute pressure unloading after transcatheter aortic valve intervention (TAVI) in patients with severe aortic stenosis and different left ventricular geometry: a multilayer longitudinal strain echocardiographicanalysis
Authors: Cimino Sara , Monosilio Sara , Luongo Federico , Neccia Matteo , Birtolo Lucia Ilaria , Salvi Nicolò , Filomena Domenico , Mancone Massimo , Fedele Francesco , Agati Luciano , Maestrini Viviana 
Published: November 2020

AbstractAim of the present study was to describe the left ventricular longitudinal strain (LS) in all myocardial layers in patients with severe aortic stenosis (AS), preserved left ventricular ejection fraction (LVEF) in different LV geometry and to compare LS analysis before and early after acute LV unloading provided by transcatheter aortic valve implantation (TAVI). 68 patients were enrolled. LS was measured from the endocardial layer (Endo-LS), epicardial layer (Epi-LS) and full thickness of myocardium (Transmural-LS) before and after TAVI. Patients were divided in two groups accordingly with relative wall thickness (RWT): concentric LV hypertrophy (cLVH) vs eccentric LV hypertrophy (eLVH). Less impaired values of LS at baseline were observed, in all layers, in patients with cLVHas compared to patients with eLVH (Endo-LS was − 13.2 ± 2 vs − 11.1±3 %, p = 0.041; Epi-LS was − 11.8 ± 1.8 vs − 9.9 ± 3 %, p = 0.043; Transmural-LS was − 12.3 ± 1.8 vs − 10.49 ± 3.3 %, p = 0.02, respectively). A significant improvement in endocardial LS (Endo-LS) after TAVI was detected only in cLVH(− 13 ± 2 vs − 14 ± 2, p = 0.011). Our findings documented that concentric LVH had better basal strain function and showed a better myocardial recovery after TAVI compared to eLVH.
Sovereignty, privacy, and ethics in blockchain-based identity management systems
Authors: Ishmaev Georgy 
Published: November 2020

AbstractSelf-sovereign identity (SSI) solutions implemented on the basis of blockchain technology are seen as alternatives to existing digital identification systems, or even as a foundation of standards for the new global infrastructures for identity management systems. It is argued that ‘self-sovereignty' in this context can be understood as the concept of individual control over identity relevant private data, capacity to choose where such data is stored, and the ability to provide it to those who need to validate it. It is also argued that while it might be appealing to operationalise the concept of ‘self-sovereignty’ in a narrow technical sense, depreciation of moral semantics obscures key challenges and long-term repercussions. Closer attention to the normative substance of the ‘sovereignty’ concept helps to highlight a range of ethical issues pertaining to the changing nature of human identity in the context of ubiquitous private data collection.
Putting learning back into learning analytics: actions for policy makers, researchers, and practitioners
Authors: Ifenthaler Dirk , Gibson David , Prasse Doreen , Shimada Atsushi , Yamada Masanori 
Published: November 2020

AbstractThis paper is based on (a) a literature review focussing on the impact of learning analytics on supporting learning and teaching, (b) a Delphi study involving international expert discussion on current opportunities and challenges of learning analytics as well as (c) outlining a research agenda for closing identified research gaps. Issues and challenges facing educators linked to learning analytics and current research gaps were organised into four themes, the further development of which by the expert panel, led to six strategy and action areas. The four themes are 1. development of data literacy in all stakeholders, 2. updating of guiding principles and policies of educational data, 3. standards needed for ethical practices with data quality assurance, and 4. flexible user-centred design for a variety of users of analytics, starting with learners and ensuring that learners and learning is not harmed. The strategies and actions are outcomes of the expert panel discussion and are offered as provocations to organise and focus the researcher, policymaker and practitioner dialogs needed to make progress in the field.
A deep learning network for estimation of seismic local slopes
Authors: Huang Wei-Lin , Gao Fei , Liao Jian-Ping , Chuai Xiao-Yu 
Published: November 2020

AbstractThe local slopes contain rich information of the reflection geometry, which can be used to facilitate many subsequent procedures such as seismic velocities picking, normal move out correction, time-domain imaging and structural interpretation. Generally the slope estimation is achieved by manually picking or scanning the seismic profile along various slopes. We present here a deep learning-based technique to automatically estimate the local slope map from the seismic data. In the presented technique, three convolution layers are used to extract structural features in a local window and three fully connected layers serve as a classifier to predict the slope of the central point of the local window based on the extracted features. The deep learning network is trained using only synthetic seismic data, it can however accurately estimate local slopes within real seismic data. We examine its feasibility using simulated and real-seismic data. The estimated local slope maps demonstrate the successful performance of the synthetically-trained network.
User preferences for privacy features in digital assistants
Authors: Ebbers Frank , Zibuschka Jan , Zimmermann Christian , Hinz Oliver 
Published: November 2020

AbstractDigital assistants (DA) perform routine tasks for users by interacting with the Internet of Things (IoT) devices and digital services. To do so, such assistants rely heavily on personal data, e.g. to provide personalized responses. This leads to privacy concerns for users and makes privacy features an important component of digital assistants.This study examines user preferences for three attributes of the design of privacy features in digital assistants, namely (1) the amount of information on personal data that is shown to the user, (2) explainability of the DA’s decision, and (3) the degree of gamification of the user interface (UI). In addition, it estimates users’ willingness to pay (WTP) for different versions of privacy features.The results for the full sample show that users prefer to understand the rationale behind the DA’s decisions based on the personal information involved, while being given information about the potential impacts of disclosing specific data. Further, the results indicate that users prefer to interact with the DA’s privacy features in a serious game. For this product, users are willing to pay €21.39 per month. In general, a playful design of privacy features is strongly preferred, as users are willing to pay 23.8% more compared to an option without any gamified elements. A detailed analysis identifies two customer clusters “Best Agers” and “DA Advocates”, which differ mainly in their average age and willingness to pay. Further, “DA Advocates” are mainly male and more privacy sensitive, whereas “Best Agers” show a higher affinity for a playful design of privacy features.