bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cadernos de Prospecção: uma brisa de esperança e alento em tempos difíceis
Authors: Farias Claudio Vinicius Silva 
Published: October 2020

<p>Vimos um tempo de mudanças. Mudanças de hábitos, costumes, tradições, que passam pelo repensar de hábitos simples (como um aperto de mãos e os abraços calorosos – que tanto caracterizam nossa brasilidade), mas também por reflexões mais profundas. Com toda a certeza, tais reflexões passarão por uma adequação e valorização do papel da Ciência e da Tecnologia em nossas sociedades.</p><p>É estranho que no florescer do século XXI ainda estejamos falando da valorização da Ciência. Isso porque em boa medida, o que define nosso avanço enquanto sociedade passa, necessariamente, pelo avanço da Ciência (e aqui trato Ciência em seu sentido mais <em>lato</em>, independente da área do conhecimento). Porém, em diversas partes do mundo, o questionamento aos princípios da Ciência foram colocados em cheque. É bom que se explique que a dúvida está na raiz do método científico, e ser colocado em cheque não é, necessariamente, um problema para os profissionais da Ciência. O problema está na qualidade das dúvidas apresentadas.</p><p>Colocar em dúvida o formato da Terra, o movimento dos astros celestes, a eficácia de procedimentos médicos não são, em verdade, dúvidas, mas um emaranhado de suposições e crenças conspiratórias. A ciência precisa ser questionada, posta em cheque, mas de forma qualificada e tendo por base o próprio método científico. Só assim teremos uma ciência propriamente evolucionária.</p><p>Essa edição da Revista Cadernos de Prospecção é um exemplo claro do que estamos falando. Ao dedicar boa parte dos artigos publicados ao levantamento prospectivo e crítico de inúmeras tecnologias, possibilita aos pesquisadores e interessados uma visão ampla e atualizada do “estado da arte” em diferentes setores e áreas do saber. É o exemplo de que o conhecimento científico, aliado aos interesses da sociedade civil gera resultados que vão muito além de bibliometrias frias e sem relações com o desenvolvimento científico, econômico e social.</p><p>Os 22 artigos aqui publicados demonstram como é possível alinhar os interesses da academia com os problemas reais da sociedade. Mostram, também, que existe uma rede muita bem montada de saberes e investigações, em parte capitaneada pelos esforços das centenas de alunos e docentes ligados ao Profnit, em todo o país. Isso fica evidenciado pela participação dos 84 autores (oriundos de 22 organizações diferentes e de 5 regiões do Brasil e Distrito Federal), que submeteram seus trabalhos ao rigoroso crivo da Revista. Todo esse esforço é como uma brisa de esperança e um alento em tempos tão difíceis.</p><p>Desejo a todos uma leitura prazerosa e parabenizo aos autores, avaliadores e revisores pela excelente edição da Cadernos de Prospecção.</p><p> </p>
2015 American College of Rheumatology Workforce Study and Demand Projections of Pediatric Rheumatology Workforce, 2015–2030
Authors: Correll Colleen K. , Ditmyer Marcia M. , Mehta Jay , Imundo Lisa F. , Klein‐Gitelman Marisa S. , Monrad Seetha U. , Battafarano Daniel F. 
Published: October 2020

ObjectiveTo describe the character and composition of the 2015 pediatric rheumatology workforce in the US, evaluate current workforce trends, and project future supply and demand of the pediatric rheumatology workforce through 2030.MethodsThe American College of Rheumatology created the workforce study group to study the rheumatology workforce. The workforce study group used primary and secondary data to create a representative workforce model. Pediatric rheumatology supply and demand was projected through 2030 using an integrated data‐driven framework to capture a more realistic clinical full‐time equivalent (FTE) and produce a better picture of access to care issues in pediatric rheumatology.ResultsThe 2015 pediatric rheumatology workforce was estimated at 287 FTEs (300 providers), while the estimated excess demand was 95 (33%). The projected demand will continue to increase to almost 100% (n = 230) by 2030 if no changes occur in succession planning, new graduate entrants into the profession, and other factors associated with the workforce.ConclusionThis study projects that the pediatric rheumatology workforce gap will continue to worsen significantly from the 2015 baseline, and by 2030 the demand for pediatric rheumatologists will be twice the supply. Innovative strategies are needed to increase the workforce supply and to improve access to care.
Palladium‐Catalyzed Distal C−H Selenylation of 2‐Aryl Acetamides with Diselenides and Selenyl Chlorides
Authors: He Meicui , Gu Linghui , Tan Yuqiang , Wang Yang , Wang Yuchi , Zhang Chunran , Ma Wenbo 
Published: October 2020

AbstractA convenient and effective method of palladium‐catalyzed C−H selenylation of the 2‐aryl acetamides assisted with removable 8‐aminoquinoline with readily available diselenides and selenyl chlorides has been developed. This selenylation reaction is scalable and tolerates a wide range of functional groups, providing a straightforward way of the preparing unsymmetrical diaryl selenides and dibenzoselene‐pinone. Preliminary mechanistic studies indicated that a single‐electron transfer type mechanism and facile C−H metalation are operative.magnified image
Metal‐Free Oxidative Double C(sp3)−C(sp3) Coupling of 1,3‐Dicarbonyl Compounds and N,N‐Dimethylanilines
Authors: Huang Ling , Cao Dongdong , Pan Jie , Fang Lingjia , Wang Qianqian , Chen Dingben , Yang Jianguo 
Published: October 2020

AbstractHerein, metal‐free oxidative tandem cross‐dehydrogenative coupling of 1,3‐dicarbonyl compounds with N,N‐dimethylanilines is developed. The reaction affords two new C(sp3)−C(sp3) bonds in one pot. A broad range of ß‐dicarbonyl compounds and N,N‐dimethylanilines were compatible, and the desired products were synthesized in moderate‐to‐good yields.magnified image
Enantioselective Michael Addition Reactions to Construct SCF3‐containing Stereocenter Catalyzed by Chiral Quaternary Phosphonium Salts
Authors: Hong Haoran , Zheng Changwu , Zhao Gang , Shang Yongjia 
Published: October 2020

AbstractThe trifluoromethylthio group is significant in drug design for its high stability, electronegativity, and lipophilicity. Herein, a series of indenone structures containing the SCF3 group and an adjacent chiral quaternary stereocenter were synthesized by an asymmetric Michael addition reaction using an ion pair catalyst derived from amino acids. The desired products were obtained in excellent yields (up to 98%) and good to high stereoselectivities (up to 97% ee and >20:1 dr).magnified image
Emergent Degradation Phenomena Demonstrated on Resilient, Flexible, and Scalable Integrated Photoelectrochemical Cells
Authors: Kistler Tobias A. , Zeng Guosong , Young James L. , Weng Lien‐Chun , Aldridge Chase , Wyatt Keenan , Steiner Myles A. , Solorzano Oscar , Houle Frances A. , Toma Francesca M. , Weber Adam Z. , Deutsch Todd G. , Danilovic Nemanja 
Published: October 2020

AbstractPhotoelectrochemical (PEC) water splitting provides a pathway to generate sustainable clean fuels using the two most abundant resources on Earth: sunlight and water. Currently, most of the successful models of PEC cells are still fabricated on small scales near 1 cm2, which largely limits the mass deployment of solar‐fuel production. Here, the scale‐up to 8 cm2 of an integrated PEC (IPEC) device is demonstrated and its performance compared to a 1 cm2 IPEC cell, using state‐of‐the‐art iridium and platinum catalysts with III–V photoabsorbers. The initial photocurrents at 1 sun are 8 and 7 mA cm−2 with degradation rates of 0.60 and 0.47 mA cm−2 day−1, during unbiased operation for the 1 and 8 cm2 devices, respectively. Evaluating under outdoor and indoor conditions at two U.S. National Laboratories reveals similar results, evidencing the reproducibility of this design's performance. Furthermore, the emerging degradation mechanisms during scale‐up are investigated and the knowledge gained from this work will provide feedback to the broader community, since PEC device durability is a limiting factor in its potential future deployment.
Clinical aspects of a large group of adults with Angelman syndrome
Authors: den Besten Inge , de Jong Rianne F. , Geerts‐Haages Amber , Bruggenwirth Hennie T. , Koopmans Marije ,   ENCORE Expertise Center for AS 18+, Brooks Alice , Elgersma Ype , Festen Dederieke A. M. , Valstar Marlies J. 
Published: October 2020

AbstractDescriptions of the clinical features of Angelman syndrome (AS) have mainly been focused on children. Here, we describe the evolution of the clinical phenotypes of AS in adulthood, using clinical data from 95 individuals (mean age 31.6 years, median 29.0 years, range 18–83 years), with genetically confirmed AS. Data was collected through physical examination and inspection of medical records, combined with questionnaires and interviews. Adults with AS experience substantial debilitating health problems. Constipation, reflux, visual problems, scoliosis, behavioral and sleeping problems occurred frequently and require appropriate attention. Epilepsy was reported in 57% of adults, negatively affecting the level of functioning. Non‐convulsive status epilepticus was not observed in the adults, however some individuals developed prolonged episodes of rhythmic shaking while awake. A decline in mobility was noted in the majority of adults. A minority of adults with AS showed microcephaly. Taken together, this first phenotypic study of adults with AS to include in person interviews with care‐givers and physical examination of patients, including the eldest adult reported to date, provides important insight in the development of the syndrome into adulthood. This knowledge is required to improve care for adult individuals with AS and to evaluate future therapies for this group.
Die gerichtete Evolution einer Halogenid‐Methyltransferase erlaubt die biokatalytische Synthese diverser SAM‐Analoga
Authors: Tang Qingyun , Grathwol Christoph W. , Aslan‐Üzel Aşkın S. , Wu Shuke , Link Andreas , Pavlidis Ioannis V. , Badenhorst Christoffel P. S. , Bornscheuer Uwe T. 
Published: October 2020

AbstractBiokatalytische Alkylierungen sind wichtige Reaktionen, um chemo‐, regio‐ und stereoselektiv alkylierte Verbindungen zu erhalten. Dies kann mit S‐Adenosyl‐l‐methionin (SAM)‐abhängigen Methyltransferasen und SAM‐Analoga erreicht werden. Kürzlich wurde gezeigt, dass eine Halogenid‐Methyltransferase (HMT) aus Chloracidobacterium thermophilum SAM ausgehend von SAH und Methyliodid herstellen kann. Wir entwickelten einen Iodid‐basierten Assay für die gerichtete Evolution einer HMT aus Arabidopsis thaliana und nutzten diesen, um eine V140T‐Variante zu identifizieren, die auch Ethyl‐, Propyl‐, und Allyliodid akzeptiert, um die entsprechenden SAM‐Analoga herzustellen (90, 50 und 70 % Umsatz ausgehend von 15 mg SAH). Die V140T‐AtHMT wurde in einer Eintopfkaskade mit O‐Methyltransferasen (IeOMT und COMT) eingesetzt, um die regioselektive Alkylierung von Luteolin und 3,4‐Dihydroxybenzaldehyd zu erzielen. Obwohl eine Kaskade zur Propylierung von 3,4‐Dihydroxybenzaldehyd niedrige Umsätze ergab, konnte das Propyl‐SAH‐Intermediat durch NMR‐Spektroskopie bestätigt werden.
Synthetic Routes for Heteroatom‐Containing Alkylated/Arylated Polycyclic Aromatic Hydrocarbons
Authors: Shi Qinqin , Shi Xiaosong , Feng Changfu , Wu Yishi , Zheng Nan , Liu Jie , Wu Xiaoxi , Chen Hao , Peng Aidong , Li Jianfeng , Jiang Lang , Fu Hongbing , Xie Zengqi , Marder Seth R. , Blakey Simon B. , Huang Hui 
Published: October 2020

AbstractSynthetic routes for heteroatom‐containing polycyclic aromatic hydrocarbons (H‐PAHs) with alkyl and aryl substitution are demonstrated. Three H‐PAHs, including heteroatom‐containing rubicenes (H‐rubicenes), angular‐benzothiophenes (ABTs), and indenothiophene (IDTs) were successfully synthesized by two key steps, including polysubstituted olefin formation and cyclization. Specifically, ABT and H‐rubicenes were comprehensively investigated by single‐crystal X‐ray diffraction, NMR spectroscopy, UV‐vis absorption, cyclic voltammetry, transient absorption, and single‐crystal OFET measurements.
Directed Evolution of a Halide Methyltransferase Enables Biocatalytic Synthesis of Diverse SAM Analogs
Authors: Tang Qingyun , Grathwol Christoph W. , Aslan‐Üzel Aşkın S. , Wu Shuke , Link Andreas , Pavlidis Ioannis V. , Badenhorst Christoffel P. S. , Bornscheuer Uwe T. 
Published: October 2020

AbstractBiocatalytic alkylations are important reactions to obtain chemo‐, regio‐ and stereoselectively alkylated compounds. This can be achieved using S‐adenosyl‐l‐methionine (SAM)‐dependent methyltransferases and SAM analogs. It was recently shown that a halide methyltransferase (HMT) from Chloracidobacterium thermophilum can synthesize SAM from SAH and methyl iodide. We developed an iodide‐based assay for the directed evolution of an HMT from Arabidopsis thaliana and used it to identify a V140T variant that can also accept ethyl‐, propyl‐, and allyl iodide to produce the corresponding SAM analogs (90, 50, and 70 % conversion of 15 mg SAH). The V140T AtHMT was used in one‐pot cascades with O‐methyltransferases (IeOMT or COMT) to achieve the regioselective ethylation of luteolin and allylation of 3,4‐dihydroxybenzaldehyde. While a cascade for the propylation of 3,4‐dihydroxybenzaldehyde gave low conversion, the propyl‐SAH intermediate could be confirmed by NMR spectroscopy.
Enhancing Performances of Polydopamine as Cathode for Lithium‐ and Potassium‐Ion Batteries by Simple Grafting of Sulfonate Groups
Authors: Aqil Abdelhafid , Jérôme Christine , Boschini Frédéric , Mahmoud Abdelfattah 
Published: October 2020

AbstractPolydopamine (PDA) is a bioderived organic electrode material which exhibits a low capacity of ∼100 mAh.g−1 due to the large PDA aggregates formed at the electrode during self‐polymerization of DA. In this work, it found that a simple grafting of sulfonate groups via Michael addition can endow sulfonated PDA with superior electrochemical performances. Benefiting from the homogeneity of the coated active material and the improved ionic conductivity, the optimized PDA delivered high storage capacities of 206 mAh.g−1 for LIBs and 82 mAh.g−1 for KIBs at a high current density of (1000 mA.g−1) with a coulombic efficiency of nearly 100 %.
Identification of preferred multimodal ligand‐binding regions on IgG1 FC using nuclear magnetic resonance and molecular dynamics simulations
Authors: Gudhka Ronak B. , Bilodeau Camille L. , McCallum Scott A. , McCoy Mark A. , Roush David J. , Snyder Mark A. , Cramer Steven M. 
Published: October 2020

AbstractIn this study, the binding of multimodal chromatographic ligands to the IgG1 FC domain were studied using nuclear magnetic resonance and molecular dynamics simulations. Nuclear magnetic resonance experiments carried out with chromatographic ligands and a perdeuterated 15N‐labeled FC domain indicated that while single‐mode ion exchange ligands interacted very weakly throughout the FC surface, multimodal ligands containing negatively charged and aromatic moieties interacted with specific clusters of residues with relatively high affinity, forming distinct binding regions on the FC. The multimodal ligand‐binding sites on the FC were concentrated in the hinge region and near the interface of the CH2 and CH3 domains. Furthermore, the multimodal binding sites were primarily composed of positively charged, polar, and aliphatic residues in these regions, with histidine residues exhibiting some of the strongest binding affinities with the multimodal ligand. Interestingly, comparison of protein surface property data with ligand interaction sites indicated that the patch analysis on FC corroborated molecular‐level binding information obtained from the nuclear magnetic resonance experiments. Finally, molecular dynamics simulation results were shown to be qualitatively consistent with the nuclear magnetic resonance results and to provide further insights into the binding mechanisms. An important contribution to multimodal ligand‐FC binding in these preferred regions was shown to be electrostatic interactions and π–π stacking of surface‐exposed histidines with the ligands. This combined biophysical and simulation approach has provided a deeper molecular‐level understanding of multimodal ligand–FC interactions and sets the stage for future analyses of even more complex biotherapeutics.
Analyzing an emerging business ecosystem through M&A activities: The case of the Bioeconomy
Authors: Waßenhoven Anna , Block Carolin , Wustmans Michael , Bröring Stefanie 
Published: October 2020

AbstractObjectivesThe business ecosystem approach has been widely used in research to analyze the role of different actors such as companies and their interdependencies within a specific business environment. However, research dealing with an emerging business ecosystem, where single actors, industry, and market structures are not clearly specified and only gradually evolve, is limited so far. Especially in emerging interindustry business ecosystems, the timely identification of potentially new cooperating sectors is highly relevant, as hitherto separate industry structures might converge. Accordingly, this article adopts an industry perspective allowing for the identification of relevant industry sectors, their respective industry affiliation as well as the development of an emerging business ecosystem.MethodsIn doing so, we propose a conceptual framework for visualizing emerging business ecosystems by drawing upon Merger and Acquisition (M&A) data. While using the case of the highly interdisciplinary emerging Bioeconomy, first, the delineation of relevant Standard Industrial Classification codes, and second, the industry network analysis of M&A data contributes to the visualization of an emerging business ecosystem.ResultsIn line with the definition of the Bioeconomy, keystone players as well as most important bridges between other sectors are the chemical and food industry.ConclusionsThe proposed framework can provide insight in the relevance of central industry sectors in forming an emerging interindustry business ecosystem, and it supports the anticipation of converging industries. Finally, it will help policy makers and managers in evaluating resource and knowledge flows across sectors involved within the business ecosystem and in depicting the status‐quo of an emerging business ecosystem.
The role of surgery on the primary tumor site in bladder cancer with distant metastasis: significance of histology type and metastatic pattern
Authors: Wang Ping , Zang Shuang , Li Guangqi , Qu Weiling , Li Shuyao , Qiao Qiao , Jiang Yuanjun 
Published: October 2020

AbstractDue to the limited data and research on bladder cancer with distant metastasis, the role of surgery on the primary tumor site in metastatic bladder cancer has been controversial. The aim of this study was to investigate the impact of surgery on patients with metastatic bladder cancer and to identify any factors correlated with the treatment efficacy. Using the Surveillance, Epidemiology and End Results dataset, we performed a large population‐based retrospective study. We classified patents with distant metastasis into subgroups according to their histology type and metastatic pattern. Propensity score matching (PSM) was used to balance clinical variables bias in a 1:3 ratio. A total of 2470 patients with distant metastasis were identified from 2010 to 2016. After PSM, the study eventually included 1068 patients in the surgery group and 356 patients in the non‐surgery group. The histologic types, the number of metastatic sites, liver metastasis, surgery, and chemotherapy were significant prognostic variables for patients with distant metastasis before and after PSM. In terms of histologic types, the survival of patients with transitional cell papillary carcinoma, transitional cell non‐papillary carcinoma and adenocarcinoma can be improved by surgery alone, while the survival of patients with squamous cell carcinoma can be improved only by combining chemotherapy and surgery. In terms of the number of metastatic sites, surgery alone was an independent prognostic factor in patients with 1 or 2 metastatic sites. In terms of the specificity of metastatic organs, surgery affected overall survival for patients with bone metastasis only, liver metastasis only and lung metastasis only, but for distant lymph nodes metastasis only. It may be helpful to classify patients with bladder cancer and distant metastasis into different groups by integrating variables including histology types and metastatic patterns to choose appropriate treatment strategies.
Low‐grade gangliogliomas in adults: A population‐based study
Authors: Lin Xiaoning , Huang Rong , Zhang Pengfei , Sun Jin , Dong Guijiang , Huang Yanlin , Tian Xinhua 
Published: October 2020

ABSTRACTBackgroundLow‐grade gangliogliomas (GGs) are rare tumors of the central nervous system in adults. This study aims to define their characteristics, prognostic factors, and the impact of different treatment patterns on survival.MethodsThe Surveillance, Epidemiology, and End Results (SEER) database was used to investigate the potential clinicopathological factors of low‐grade GGs in adult patients (age ≥18 years). Kaplan–Meier method and Cox regression model were utilized to evaluate the associations between variables and overall survival (OS).ResultsA total of 703 adult patients diagnosed with low‐grade GGs were identified between 2004 and 2016, with a median follow‐up period of 60.0 months. The median age at diagnosis was 32.0 years, with 50.1% of patients being male, 84.2% white people, and 40.2% of married status. The predominant tumor site was located in temporal lobe (38.8%). The median OS time for the whole cohort was not reached. The 5‐ and 10‐year OS rates for patients underwent gross total resection (GTR) were 92.5% and 87.2%, respectively. Univariate and multivariate analysis showed age, gender, tumor site, and treatment pattern were significant factors for OS. The employment of adjuvant radiotherapy (RT) and/or chemotherapy would significantly shorten OS time.ConclusionsThis is the largest retrospective study of adult low‐grade GGs up to date. Younger age, female gender, temporal lobe location, and GTR indicated better survival. Adjuvant RT and/or chemotherapy should not be considered after whatever surgery in adult patients with low‐grade GGs, unless the malignant transformation has been confirmed.