bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic Surgery Without Decompressive Craniectomy in Large Putaminal Intracerebral Hemorrhage: Assessment of Efficacy and Safety
Authors: Ye Yuanliang , Wang Qiujing , Ou Weiyang , He Jian , Zhao Zhenhui 
Published: December 2019

AbstractBackgroundDecompressive craniectomy (DC) is performed conventionally for large putaminal intracerebral hemorrhage (ICH). However, DC causes local skull defect and leads to post-surgical cranioplasty. The aim of this study is to investigate the effectiveness and safety of an endoscopic procedure to treat large putaminal ICH without DC.MethodsThis retrospective study included 112 large putaminal ICH patients who underwent hematoma evacuations with either an endoscopic procedure (group A) or with DC (group B) between January 2009 and June 2017. The efficacy was evaluated by mean modified Rankin Scale (mRS) three months after surgery. Safety was evaluated by mortality rate and postoperative complications. Univariate and multivariate logistic regression analyses were performed to determine the risk factors for clinical outcomes.ResultsThe study included 49 patients in group A and 63 in group B. The mRS scores in both groups were similar after 3 months’ follow-up (p = 0.709). There was no difference in the mortality rate between the two groups (p = 0.538). The rate of complications was lower in group A than that in group B (p = 0.024). Smaller preoperative midline shift (p = 0.008) and absent intraventricular extension (p = 0.044) have contributed significantly to better outcomes.ConclusionEndoscopic hematoma evacuation without DC is safe and effective for patients with large putaminal ICH and deserves further investigation, preferably in a randomized controlled setting.
Identification of Key Candidate Genes and Pathways of Candida albicans-Infected Human Umbilical Vein Endothelial Cells and Drug Screening
Authors: Jiang Wei , Liu Ping , Zhang Jianlei , Yang Wenjie 
Published: December 2019

AbstractCandida albicans is a common opportunistic pathogen that can cause serious infection by blood transmission. C. albicans enters the blood circulation and adheres to the endothelial cells of the vascular wall. However, the detailed mechanism of the effect of C. albicans on the endothelial cells remains unclear. In this study, the microarray expression profile of human umbilical vein endothelial cells exposed to C. albicans was analyzed. The 191 up-regulated genes were enriched in TNF, T cell receptor, and NF-kappa B signaling pathways. The 71 down-regulated genes were enriched in pyruvate metabolic, purine nucleotide metabolic, purine nucleotide biosynthetic, and humoral immune response processes. Gene set enrichment analysis showed that apoptosis, oxidative phosphorylation, IL6/JAK/STAT3 signaling pathways were enriched. Moreover, two hub genes with a high degree of connectivity, namely, MYC and IL6, were selected. Molecular screening of traditional Chinese medicine libraries was performed on the basis of the structure of MYC protein. The okanin had the highest docking score. MYC might be used as molecular targets for treatment. In addition, okanin may inhibit the infection of C. albicans. Thus, MYC can be subjected to further research.
Determination of the Direct Activity of the Maltogenic Amylase from Geobacillus stearothermophilus in White Bread
Authors: Reichenberger Katrin , Luz Anja , Seitl Ines , Fischer Lutz 
Published: December 2019

AbstractAn assay-based method was developed to determine the residual activity of the maltogenic amylase from Geobacillus stearothermophilus in white bread. It was found that the important step for amylase extraction from the bread matrix was the addition of 10% (w/v) maltodextrin in the extraction buffer. The endogenous amylase activity in dough was investigated, and its inactivation during bread baking was proven. Thus, all amylase activities measured after baking have an exogenous origin. The amylase activities in the loaf of self-baked white bread containing defined dosages of exogenous amylase (10–100 μg per g flour) were reproducibly determined with 17.8 ± 1.24% residual activity. Moreover, an amylase activity of 369 ± 34.3 pkat gbread−1 was determined in three batches of a commercial white bread. The real temperature impact on the amylase during bread baking was investigated. The highest temperature in the crumb was 97 °C and, therefore, is significantly lower than the oven temperature (230 °C).
Colon cancer of Peutz-Jeghers syndrome with gallolyticus endocarditis
Authors: Miyahara Kiyoshi , Tobe Shunichi , Shizuku Tatsunori , Inamoto Rin , Katayama Ikuo 
Published: December 2019

AbstractWe report a case of Peutz-Jeghers syndrome with gallolyticus endocarditis which has not yet been reported. Colon cancer was observed and implicated in Peutz-Jeghers syndrome. A 44-year-old female with fever and heart murmur was diagnosed as infective endocarditis caused by streptococcus gallolyticus. After treatment with antibiotics and mitral valbuloplasty, we performed gastrointestinal endoscopic studies and found polyps in stomach and colon. Histological findings of a large pedunculated colon polyp revealed hamartomatous polyp with a lesion of adenocarcinoma with adenoma. She had pigmentation of digits. Her father had also digits pigmentation and died of pancreas cancer. Peutz-Jeghers syndrome with colon cancer was incidentally diagnosed by infective endocarditis and subsequent colonoscopy.
Experimental study of Zubair shale stability of east Baghdad oil field using different additives in water based mud
Authors: Alwassiti Asawer A. , AL-Bidry Mayssaa Ali , Mohammed Khalid 
Published: December 2019

AbstractShale formation is represented as one of the challenge formations during drilling wells because it is a strong potential for wellbore instability. Zubair formation in Iraqi oil fields (East Baghdad) is located at a depth from 3044.3 to 3444 m. It is considered as one of the most problematic formations through drilling wells in East Baghdad. Most problems of Zubair shale are swelling, sloughing, caving, cementing problem and casing landing problem caused by the interaction of drilling fluid with the formation. An attempt to solve the cause of these problems has been adapted in this paper by enhancing the shale stability through adding additives to the drilling fluid. The study includes experiments by using two types of drilling fluids, API and polymer type, with five types of additives (KCl, NaCl, CaCl2, Na2SiO3 and Flodrill PAM 1040) in different concentrations (0.5, 1, 5 and 10) wt% and different immersion period (1, 24 and 72 h) hours. The effect of drilling fluids and additive salts on shale has been studied by using different techniques: (XRD, XRF, reflected and transmitted microscope) as well shale recovery. The results show that adding 10 wt% of Na2SiO3 to API drilling fluid results in a high percentage of shale recovery (78.22%), while the maximum shale recovery was (80.57%) in polymer drilling fluid type gained by adding 10 wt% of Na2SiO3.
Numerical solution of an integral equation arising in the problem of cruciform crack using Daubechies scale function
Authors: Mouley Jyotirmoy , Panja M. M. , Mandal B. N. 
Published: December 2019

Abstract
This paper is concerned with obtaining approximate numerical solution of a classical integral equation of some special type arising in the problem of cruciform crack. This integral equation has been solved earlier by various methods in the literature. Here, approximation in terms of Daubechies scale function is employed. The numerical results for stress intensity factor obtained by this method for a specific forcing term are compared to those obtained by various methods available in the literature, and the present method appears to be quite accurate.
Fish Allergy Management: From Component-Resolved Diagnosis to Unmet Diagnostic Needs
Authors: Klueber Julia , Schrama Denise , Rodrigues Pedro , Dickel Heinrich , Kuehn Annette 
Published: December 2019

Abstract

Purpose of review
Fish is a common elicitor of IgE-mediated food allergy. Fish includes a large variety of foods, in terms of species and food processing, with marked distinction in local diets around the globe. Fish-allergic patients present with phenotypic diversity and major differences in levels of clinical cross-reactivity, features that pose an important challenge for the clinical diagnosis and management.

Recent findings
Parvalbumin is the major fish allergen. However, a single molecule is not sufficient but several homologs, allergens different from parvalbumin and allergen extracts, are needed for IgE-based diagnosis.

Summary
Parvalbumin-specific IgE are markers for clinical cross-reactions. Added value is provided by IgE typing to parvalbumin homologs from distantly related fish. IgE co-sensitization profiles (parvalbumin, enolase, aldolase) are referred as severity markers. The allergen panel seems to be not yet complete why fish extracts still play a crucial role in serum IgE analysis. Further clinical validation of a multiplex approach in molecular fish allergy diagnosis is needed for striving to avoid unnecessary food restrictions and in a further sense, improved patient care.
Photocatalytic H2 Evolution on TiO2 Assembled with Ti3C2 MXene and Metallic 1T-WS2 as Co-catalysts
Authors: Li Yujie , Ding Lei , Yin Shujun , Liang Zhangqian , Xue Yanjun , Wang Xinzhen , Cui Hongzhi , Tian Jian 
Published: December 2019

AbstractThe biggest challenging issue in photocatalysis is efficient separation of the photoinduced carriers and the aggregation of photoexcited electrons on photocatalyst’s surface. In this paper, we report that double metallic co-catalysts Ti3C2 MXene and metallic octahedral (1T) phase tungsten disulfide (WS2) act pathways transferring photoexcited electrons in assisting the photocatalytic H2 evolution. TiO2 nanosheets were in situ grown on highly conductive Ti3C2 MXenes and 1T-WS2 nanoparticles were then uniformly distributed on TiO2@Ti3C2 composite. Thus, a distinctive 1T-WS2@TiO2@Ti3C2 composite with double metallic co-catalysts was achieved, and the content of 1T phase reaches 73%. The photocatalytic H2 evolution performance of 1T-WS2@TiO2@Ti3C2 composite with an optimized 15 wt% WS2 ratio is nearly 50 times higher than that of TiO2 nanosheets because of conductive Ti3C2 MXene and 1T-WS2 resulting in the increase of electron transfer efficiency. Besides, the 1T-WS2 on the surface of TiO2@Ti3C2 composite enhances the Brunauer–Emmett–Teller surface area and boosts the density of active site.
Treatment and Outcome of Patients with Uterine Carcinosarcoma in a Comprehensive Cancer Network
Authors: Hapsari K. , Bhugwandass C. , van Rijn G. W. J. , van der Wurff A. A. M. , van ‘t Veer M. , Boll D. , Vos M. C. , Pijlman B. , Kok A. , Piek J. M. J. 
Published: December 2019

Abstract
Aim
To determine clinical characteristics, treatment modalities and survival of uterine carcinosarcoma (UCS).

Methods
Data on treatment of UCS patients in the Comprehensive Cancer Network south region in the Netherlands between 2004 and 2014 were retrospectively evaluated.

Results
Data of 62 patients with UCS were retrieved. Mean age at diagnosis was 69.2 years (45–95 years). Data of six patients were excluded because they did not receive any treatment. Of the 56 patients included in this study, 57.1% presented with early-stage (FIGO I–II) disease and 42.9% with late-stage (FIGO III–IV) disease. 46.9% of the patients with FIGO early-stage disease received only surgical treatment, whereas 9.4% received adjuvant chemotherapy and 43.8% received adjuvant radiotherapy. Median DFS in patients with early-stage disease was 47.0 months (17.5–72.0). Adjuvant therapy did not seem to alter prognosis (p = 0.261). 16.7% of the patients with late-stage disease received only surgical treatment, 12.5% received only chemotherapy, whereas 50% received adjuvant chemotherapy and 20.8% adjuvant radiotherapy after surgery. Median DFS in late-stage disease was 8.5 months (2.5–23.5). Adjuvant therapy did not seem to alter prognosis (p = 0.30).

Conclusion
UCS with both FIGO stages I–II and III–IV has a dismal prognosis. The addition of adjuvant treatment did not seem to increase survival.
Is Mode of Delivery Associated With Sexual Response? A Pilot Study of Genital and Subjective Sexual Arousal in Primiparous Women With Vaginal or Cesarean Section Births
Authors: Cappell Jackie , Bouchard Katrina N. , Chamberlain Susan M. , Byers-Heinlein Alyssa , Chivers Meredith L. , Pukall Caroline F. 
Published: December 2019

Abstract

Introduction
Although postpartum sexual concerns are common, limited data exist on postpartum sexual response. Furthermore, the physiological process of vaginal birth may negatively impact genital response compared with unlabored cesarean section (C-section), but this hypothesis has yet to be tested.

Aim
To (i) compare genital and subjective sexual response and sexual concordance by mode of delivery with inclusion of a control group, (ii) compare groups on self-reported sexual function over the past month, (iii) examine the relationship between laboratory measurement of sexual response and self-reported sexual function, and (iv) investigate association between obstetrical factors and breastfeeding and between sexual response and self-reported sexual function.

Methods
3 groups of cisgender women were recruited from the community: primiparous women who delivered via vaginal birth within the past 2 years (VB group; n = 16), primiparous women who delivered via unlabored C-section within the past 2 years (CS group, n = 15), and age-matched nulliparous women (NP group, n = 18). Laser Doppler imaging was used to assess genital response while participants watched a neutral and erotic film.

Main Outcome Measures
The main outcome measures were change in flux units from neural to erotic video as a measure of genital response, subjective sexual arousal rated continuously throughout films, perceived genital response rated after films, and Female Sexual Function Index (FSFI).

Results
Women in the VB group had significantly lower change in flux units than women in the CS (P = .005, d = 1.39) and NP (P &lt; .001, d = 1.80) groups. Groups did not differ on their subjective indices of sexual response or in sexual concordance. Women in both postpartum groups reported lower FSFI scores than women in the NP group. No relationship was determined between FSFI scores and sexual response in the laboratory. Results suggested that genital trauma and breastfeeding may negatively impact FSFI scores, but they were not related to genital response or subjective sexual arousal as measured in the laboratory.

Clinical Implications
Results underscore the importance of balancing objective and subjective indices of sexual response and function, especially considering the biopsychosocial nature of postpartum sexuality.

Strengths & Limitations
The present study is the first to apply modern sexual psychophysiological methodology to the study of postpartum sexuality. Cross-sectional methodology limits the ability to make causal inferences, and the strict inclusion criteria limits generalizability.

Conclusion
Physiological changes as a result of labor and delivery may have a detrimental impact on genital response; however, these physiological differences may not impact women's subjective experience of postpartum sexuality.
Highly efficient continuous-wave mid-infrared generation based on intracavity difference frequency mixing
Authors: Xi Cheng , Wang Peng , Li Xiao , Liu Zejin 
Published: December 2019

We report on a new scheme for efficient continuous-wave (CW) mid-infrared generation using difference frequency generation (DFG) inside a periodically poled lithium niobate (PPLN)-based optical parametric oscillator (OPO). The pump sources were two CW fiber lasers fixed at 1018 nm and 1080 nm. One worked as the assisted laser to build parametric oscillation and generate an oscillating signal beam while the other worked at low power (

${\leqslant}3~\text{W}$

) to induce DFG between it and the signal beam. The PPLN temperature was appropriately adjusted to enable OPO and DFG to synchronously meet phase-matching conditions. Finally, both low-power 1018 nm and 1080 nm pump beams were successfully converted to

$3.1~\unicode[STIX]{x03BC}\text{m}$

and

$3.7~\unicode[STIX]{x03BC}\text{m}$

idler beams, respectively. The conversion efficiencies of the 1018 nm and 1080 nm pumped DFG reached 20% and 15%, respectively, while their slope efficiencies reached 19.6% and 15%. All these data were comparable to the OPOs pumped by themselves and never realized before in traditional CW DFG schemes. The results reveal that high-efficiency frequency down-conversion can be achieved with a low-power near-infrared pump source.
National Minority Rights and Democratic Political Community: Experience and Perspective of the OSCE High Commissioner on National Minorities
Authors: Marsal Stéphanie 
Published: December 2019

AbstractThis article examines the OSCE HCNM experience with regard to situations where cultural autonomy arrangements exist and discusses the potential contribution of such arrangements to managing ethnic diversity. It reviews some of the salient issues that have arisen with regard to the legal and political framework of these arrangements. This article highlights the importance for bodies of cultural autonomy to comply with good governance principles, including respect for diversity within minority groups and insists on a more inclusive approach to autonomy.
Do (Should) Brokers Route Limit Orders to Options Exchanges That Purchase Order Flow?
Authors: Battalio Robert , Griffith Todd , Van Ness Robert 
Published: December 2019

AbstractWe examine whether options exchanges’ pricing schedules affect broker order routing behavior and limit order execution quality. We find that some brokers seemingly maximize the value of their order flow by selling marketable orders and sending nonmarketable orders to exchanges that offer large liquidity rebates. Other brokers appear to bypass liquidity rebates by routing both marketable and nonmarketable orders to exchanges that purchase order flow. Using a decision by the Philadelphia Stock Exchange (PHLX) to change its trading protocol, we provide empirical evidence that brokers can enhance limit order execution quality by routing nonmarketable limit orders to options exchanges that purchase order flow.
In vitro activity of essential oils against adult and immature stages of Ctenocephalides felis felis
Authors: dos Santos João Vitor Barbosa , de Almeida Chaves Douglas Siqueira , de Souza Marco André Alves , Riger Cristiano Jorge , Lambert Monique Moraes , Campos Diefrey Ribeiro , Moreira Leandra Oliveira , dos Santos Siqueira Rosiane Conceição , de Paulo Osorio Rodrigo , Boylan Fabio , Correia Thaís Ribeiro , Coumendouros Katherina , Cid Yara Peluso 
Published: December 2019

AbstractEssential oils (EOs) are considered a new class of ecological products aimed at the control of insects for industrial and domestic use; however, there still is a lack of studies involving the control of fleas. Ctenocephalides felis felis, the most observed parasite in dogs and cats, is associated with several diseases. The aim of this study was to evaluate the in vitro activity, the establishment of LC50 and toxicity of EOs from Alpinia zerumbet (Pers.) B. L. Burtt & R. M. Sm, Cinnamomum spp., Laurus nobilis L., Mentha spicata L., Ocimum gratissimum L. and Cymbopogon nardus (L.) Rendle against immature stages and adults of C. felis felis. Bioassay results suggest that the method of evaluation was able to perform a pre-screening of the activity of several EOs, including the discriminatory evaluation of flea stages by their LC50. Ocimum gratissimum EO was the most effective in the in vitro assays against all flea stages, presenting adulticide (LC50 = 5.85 μg cm−2), ovicidal (LC50 = 1.79 μg cm−2) and larvicidal (LC50 = 1.21 μg cm−2) mortality at low doses. It also presented an excellent profile in a toxicological eukaryotic model. These findings may support studies involving the development of non-toxic products for the control of fleas in dogs and cats.
Besnoitia besnoitibradyzoite stages induce suicidal- and rapid vital-NETosis
Authors: Zhou Ershun , Silva Liliana M. R. , Conejeros Iván , Velásquez Zahady D. , Hirz Manuela , Gärtner Ulrich , Jacquiet Philippe , Taubert Anja , Hermosilla Carlos 
Published: December 2019

AbstractBesnoitia besnoitiis an obligate intracellular apicomplexan protozoan parasite, which causes bovine besnoitiosis. Recently increased emergence within Europe was responsible for significant economic losses in the cattle industry due to the significant reduction of productivity. However, still limited knowledge exists on interactions betweenB. besnoitiand host innate immune system. Here,B. besnoitibradyzoites were successfully isolated from tissue cysts located in skin biopsies of a naturally infected animal, and we aimed to investigate for the first time reactions of polymorphonuclear neutrophils (PMN) exposed to these vital bradyzoites. Freshly isolated bovine PMN were confronted toB. besnoitibradyzoites. Scanning electron microscopy (s.e.m.)- and immunofluorescence microscopy-analyses demonstrated fine extracellular networks released by exposed bovine PMN resembling suicidal NETosis. Classical NETosis components were confirmedviaco-localization of extracellular DNA decorated with histone 3 (H3) and neutrophil elastase (NE). Live cell imaging by 3D holotomographic microscopy (Nanolive®) unveiled rapid vital NETosis against this parasite. A significant increase of autophagosomes visualized by specific-LC3B antibodies and confocal microscopy was observed inB. besnoiti-stimulated bovine PMN when compared to non-stimulated group. As such, a significant positive correlation (r = 0.37;P= 0.042) was found betweenB. besnoiti-triggered suicidal NETosis and autophagy. These findings suggest that vital- as well as suicidal-NETosis might play a role in early innate host defence mechanisms against releasedB. besnoitibradyzoites from tissue cysts, and possibly hampering further parasitic replication. Our data generate first hints on autophagy being associated withB. besnoitibradyzoite-induced suicidal NETosis and highlighting for first time occurrence of parasite-mediated vital NETosis.
Intersectionality and international polar research
Authors: Seag M. , Badhe R. , Choudhry I. 
Published: December 2019

Abstract
Recent initiatives in polar research like Women in Polar Science and Women of the Arctic have shone a light on the strengths of female polar researchers and the struggles they have faced in their respective careers. These initiatives have started and contributed to ongoing conversations in the polar research community about increasing diversity and making the field more inclusive. In this commentary, we discuss the need to focus on intersectionality in diversity, equality and inclusion initiatives in polar research, and to address intersecting barriers faced by members and would-be members of our fields. These barriers are varied, often overlapping, and include, but are not limited to: gender identity; sexuality; socio-economic status; language; disability; and race. Polar research is poised to benefit from a tremendous diversity of ideas and approaches if we as a community can fully commit ourselves to understanding and addressing overlapping, interconnected barriers to equality and progress in polar research.