bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liderazgo en el clima empresarial Mao Underaction EC del Cantón Ambato de la Provincia de Tungurahua
Authors: Gonzales Reyes Jorge Vladimir , Núñez Medardo Medardo Andrés Paredes , López Rocío Núñez , Núñez Verónica Paredes , Núñez Isaac Israel Paredes 
Published: February 2020

El presente trabajo se basa en el liderazgo en el clima laboral de la empresa Mao Underaction EC del Cantón Ambato de la provincia de Tungurahua. El trabajo partió de la formulación de un objetivo general en torno al cual se traza cual es el liderazgo que caracteriza el trabajo diario dentro de las empresas y la relación existente entre el empleador y sus colaboradores, se prosigue con el marco teórico, que permite definir el concepto que debe marcar un lugar de trabajo armónico, para así poder alcanzar resultados de producción, con eficiencia y eficacia. Para lograrlo se realizó un análisis sobre la influencia del liderazgo en el clima laboral para determinar los efectos positivos en sus directivos y colaboradores. Dentro de la metodología aplicada se eligió la modalidad de investigación aplicada de campo y como instrumento se empleó la encuesta, la población objeto de estudio seleccionada fue 50 personas de la empresa escogida como campo de estudio estuvo constituida por empleador y trabajadores. La encuesta estuvo estructurada así: 10 preguntas enfocadas hacia el concepto de Salario, definición del Ambiente Laboral, precisión de los Procesos, medición del nivel de Desempeño y Satisfacción Laboral, Entorno Físico, Relaciones Interpersonales, Valores Organizacionales, Normas y Autorrealización. Una vez evaluados los Resultados quedó demostrado que la mayoría de la población considera objeto de estudio expreso que la empresa no mantiene un liderazgo acorde a las expectativas de los trabajadores, lo cual influye de manera negativa en el rendimiento y eficiencia de la población trabajadora.
A simple method for water balance estimation based on the empirical method and remotely sensed evapotranspiration estimates
Authors: Falalakis George , Gemitzi Alexandra 
Published: February 2020

Abstract
Developing a methodology for water balance estimation is a significant challenge, especially in areas with little or no gauging. This is because direct measurements of all the water balance components are not feasible. To overcome this issue, we propose a simple methodology based on the predefined empirical relationship between remotely sensed evapotranspiration (ET), i.e. Moderate Resolution Imaging Spectroradiometer (MODIS) ET and groundwater recharge (GR), and readily available precipitation data at the monthly time step. The developed methodology was applied in seven catchments in NE Greece using time series of precipitation and remotely sensed ET from 2009 to 2019. The potential of the proposed method to accurately estimate the water balance was assessed by the comparison of the individual water balance components against modeled values. Three performance metrics were examined and indicated that the methodology produces a satisfactory outcome. Our results indicated mean ET accounting for approximately 54% of precipitation, mean GR of 24% and mean surface runoff approximately 22% of precipitation in the study area. The proposed approach was implemented using freely available remotely sensed products and the free R software for statistical computing and graphics, offering thus a convenient and inexpensive alternative for water balance estimation, even for basins with limited data availability.
The Mediating Effect of Different Exercise Programs on the Immune Profile of Frail Older Women with Cognitive Impairment
Authors: Eustáquio Furtado G. , Uba Chupel M. , Guerra Minuzzi L. , Luis Rama , Carlos Colado J. , Eef Hogervorst , Pedro Ferreira J. , Maria Teixeira A. 
Published: February 2020

Background:
Frail individuals experience an accelerated immunosenescence, and exercise has been
identified as a therapy to promote a better inflammatory environment.

Objective:
To analyze the effects of 28-weeks of two different exercise protocols on the functional fitness and
immune profiles of institutionalized pre-frail and frail women with mild cognitive impairment.

Methods:
Participants residing in care homes (n=60, 81±7.84 years old) were randomized into three groups: a
chair elastic band muscle-strength exercise (CSE, n=21; 81±4.79), a chair multimodal exercise (CME, n=20;
80±8.19), and a control non-exercise (CGne, n=19; 80±10.01). Both CME and CSE groups performed
progressive circuit-training exercise sessions. The controls did not change their usual lifestyle. The Fried protocol
and the Mini-Mental State Examination questionnaire were used to identify the frail subgroups and the
participants with mild cognitive impairment. Data for anti and pro-inflammatory markers and physical fitness
were analyzed pre and post-interventions.

Results:
After the intervention, a significant effect of time and time by group for sIgA and time by group for IL-
10 levels were found (p > 0.05). Within-group analysis showed a significant moderate decrease in the TNF-α to
IL-10 ratio for the CME group and an increase in the controls (p > 0.05) and a slight reduction in the IL-6 and IL-
1β concentrations. The controls showed a negative trend towards a decrease in physical fitness and a trend for
increased levels in the pro-inflammatory markers IL-6 and IL-1β.

Conclusions:
The evidence regarding the use of systematic and moderate long-term exercise as therapy for
promoting a better balance between pro- and anti-inflammatory environments and a decrease in the inflammatory
index for the CME group were the most promising results from this study.
Molecular Docking, Synthesis and anti-HIV-1 Protease Activity of Novel Chalcones
Authors: Turkovic Nemanja , Ivkovic Branka , Kotur-Stevuljevic Jelena , Tasic Milica , Marković Bojan , Vujic Zorica 
Published: February 2020

Background:Since the beginning of the HIV/AIDS epidemic, 75 million people have been infected with the HIV and about 32 million people have died of AIDS. Investigation of the molecular mechanisms critical to the HIV replication cycle led to the identification of potential drug targets for AIDS therapy. One of the most important discoveries is HIV-1 protease, an enzyme that plays an essential role in the replication cycle of HIV.Objective:The aim of the present study is to synthesize and investigate anti-HIV-1 protease activity of some chalcone derivatives with the hope of discovering new lead structure devoid drug resistance.Methods:20 structurally similar chalcone derivatives were synthesized and their physico-chemical characterization was performed. Binding of chalcones to HIV-1 protease was investigated by fluorimetric assay. Molecular docking studies were conducted to understand the interactions.Results:The obtained results revealed that all compounds showed anti-HIV-1 protease activity. Compound C1 showed the highest inhibitory activity with an IC50 value of 0.001 μM, which is comparable with commercial product Darunavir.Conclusion:It is difficult to provide general principles of inhibitor design. Structural properties of the compounds are not the only consideration; ease of chemical synthesis, low molecular weight, bioavailability, and stability are also of crucial importance. Compared to commercial products the main advantage of compound C1 is the ease of chemical synthesis and low molecular weight. Furthermore, compound C1 has a structure that is different to peptidomimetics, which could contribute to its stability and bioavailability.
Antioxidant Phytochemicals in Pulses and their Relation to Human Health: A Review
Authors: Ciudad-Mulero María , Matallana-González Mª Cruz , Cámara Montaña , Fernández-Ruiz Virginia , Morales Patricia 
Published: February 2020

:Pulses are a staple food cultivated since ancient times, which play an important role in the human diet. From a nutritional point of view, pulses are very interesting foods as they are rich in proteins, carbohydrates and dietary fibre. Dietary antioxidants are a complex mixture of hydrophilic and lipophilic compounds usually present in foods of plant origin, including pulses. In the present study, the phytochemical composition of selected pulses (common beans, fava beans, lentils, chickpeas, peas and lupins) has been reviewed in terms of their content of antioxidant compounds. The content of hydrosoluble antioxidants (organic acids, phenolic compounds), liposoluble antioxidants (tocopherols, carotenoids) and other compounds which exert antioxidant properties, such as dietary fibre and minerals (zinc, selenium), has been studied, reporting that pulses are an interesting source of these compounds, which have important health benefits, including a preventing role in cardiovascular diseases, anticarcinogenic or neuroprotective properties.:It is important to take into account that pulses are not usually consumed raw, but they must be processed before consumption in order to improve their nutritional quality and their palatability, therefore, the effect of different technological and heat treatments (germination, cooking, boiling, extrusion) on the antioxidant compounds present in pulses has been also reviewed. In this regard, it has been observed that as a consequence of processing, the content of phytochemicals with antioxidant properties is usually decreased, but processed pulses maintain relevant amounts of these compounds, preserving their beneficial health effect.
Natural Antioxidants, Health Effects and Bioactive Properties of Wild Allium Species
Authors: Petropoulos Spyridon A. , Di Gioia Francesco , Polyzos Nikos , Tzortzakis Nikos 
Published: February 2020

Background:There is an increasing interest from the pharmaceutical and food industry in natural antioxidant and bioactive compounds derived from plants as substitutes for synthetic compounds. The genus Allium is one of the largest genera, with more than 900 species, including important cultivated and wild species, having beneficial health effects.Objective:The present review aims to unravel the chemical composition of wild Allium species and their healthrelated effects, focusing on the main antioxidant compounds. For this purpose, a thorough study of the literature was carried out to compile reports related to health effects and the principal bioactive compounds. Considering the vast number of species, this review is divided into subsections where the most studied species are presented, namely Allium ampeloprasum, A. flavum, A. hookeri, A. jesdianum, A. neapolitanum, A. roseum, A. stipitatum, A. tricoccum, and A. ursinum, with an additional composite section for less studied species.Methods:The information presented in this review was obtained from worldwide accepted databases such as Scopus, ScienceDirect, PubMed, Google Scholar and Researchgate, using as keywords the respective names of the studied species (both common and Latin names) and the additional terms of “antioxidants” “health effects” and “bioactive properties”.Conclusion:The genus Allium includes several wild species, many of which are commonly used in traditional and folklore medicine while others are lesser known or are of regional interest. These species can be used as sources of natural bioactive compounds with remarkable health benefits. Several studies have reported these effects and confirmed the mechanisms of action in several cases, although more research is needed in this field. Moreover, considering that most of the studies refer to the results obtained from species collected in the wild under uncontrolled conditions, further research is needed to elucidate the effects of growing conditions on bioactive compounds and to promote the exploitation of this invaluable genetic material.
De uniciteit van het huwelijk. Over christelijke volharding in een landschap van veranderende partnerrelaties
Authors: Hoek J. 
Published: February 2020

This article reaffirms the classic definition of marriage as the biblically founded prototypical relation between a man and a woman. It briefly reviews the radical shifts in in the understanding and practices of sexual relationships within western culture and - to an increasing extent- also in the circles of orthodox (reformed) Protestantism. A response to the growing tension between affirmed principles and lived practices, requires combining clarity with cordiality and orthodoxy with hospitality.
O Estado Nacional no contexto da internacionalização
Authors: Freire Roberto 
Published: February 2020

O Estado é a alavanca econômica e social. A competitividade com o controle do Estado nas economias sociais é fundamental para a democracia. O mercado não é livre e tem que sofrer regulação social. É preciso um Estado que tenha a eficiência e a competência para nos tornar competitivos no processo de internacionalização. Nesse sentido, é necessário um projeto cujas características respeite a realidade em que vivemos.
Democratização da mídia: redefinição das relações comunidade/Estado/informação
Authors: Allan Filho Dilermando 
Published: February 2020

O artigo trata das relações Estado x sociedade, analisando o papel e interesses de cada um dos atores sociais. Faz uma avaliação de como essa relação é estabelecida no confronto e na cooptação. Retoma a questão da censura da produção intelectual, seja ela velada ou explícita e analisa a condição de dependência da sociedade face à existência numerosa de organismos de incentivo e controle dessa produção. Registra o atual estágio da legislação referente à liberdade de manifestação do pensamento e da informação. Finalmente, aponta direções e questiona de onde virá o movimento de transformação dos meios de comunicação na busca de sua democratização. A iniciativa caberá a quem? À sociedade civil ou ao Estado?
Da administração pública burocrática à gerencial
Authors: Bresser Pereira Luiz Carlos 
Published: February 2020

Este artigo analisa os aspectos essenciais da reforma administrativa do Estado que está sendo proposta pelo Governo Fernando Henrique Cardoso. Como resposta à crise do Estado e ao processo de globalização da economia mundial, essa proposta visa fundamentalmente implantar uma administração do tipo gerencial no setor público brasileiro, em contraposição a uma administração do tipo burocrática, atualmente predominante. No texto, faz-se uma análise da crise da administração pública burocrática brasileira e são definidas as linhas mestras para a implantação da administração pública gerencial, fundamental para responder à redefinição das funções do Estado. Finalmente, relacionam-se as ações realizadas pelo Estado, que podem ser divididas em quatro tipos — núcleo estratégico, atividades exclusivas de Estado, serviços sociais competitivos ou não exclusivos, e produção para o mercado — com três tipos de propriedade. Os primeiros dois tipos de ações estão relacionados à propriedade pública estatal; o terceiro tipo de ação à propriedade pública não-estatal; e o quarto tipo de ação à propriedade privada.
Descentralização e good government: como aperfeiçoar o desempenho dos governos locais?
Authors: Brose Markus 
Published: February 2020

O país vem passando por um acelerado processo de descentralização desde a Constituição de 1988. Os Governos Locais vem recebendo uma carga de atribuições crescente, sem que haja um planejamento ou um debate na sociedade sobre os limites deste processo. Além disso, não ocorre a descentralização fiscal necessária como contrapartida. Seguindo uma longa tradição histórica, os Governos Federal e Estaduais não confiam nos Governos Locais e vem criando uma série de mecanismos de pressão e controle sobre os Governos Locais. Por meio de uma pesquisa realizada junto a municípios de caráter rural no Rio Grande do Sul, foi efetuado um diagnóstico acerca da percepção de lideranças locais sobre este processo. Ao final, é proposta uma inversão da lógica atual: fortalecer a capacidade de autogestão dos Governos Locais.
Mudanças organizacionais no processo de modernização da Secretaria da Fazenda do Estado de Pernambuco
Authors: Boeckmann Clara Emilie , Andrade Nevton Borba de 
Published: February 2020

A partir de 1998, teve início, na Secretaria da Fazenda do Estado de Pernambuco, o Programa de Modernização Fazendária (Promofaz), que promoveu diversas mudanças organizacionais, concentrando esforços em projetos estruturadores, incluindo investimentos no planejamento de tecnologia da informação (TI). Dentre os projetos de TI, destacou-se a elaboração das arquiteturas de sistemas e tecnológicas. Neste trabalho, foi realizada uma revisão dos processos organizacionais da modernização fazendária, abrangendo aspectos de cultura, mudança e aprendizagem organizacionais, confrontados com referenciais históricos e teóricos, e maior enfoque na área de tecnologia da informação. Apesar das dificuldades, o processo de informatização tem provocado fortes impactos nos componentes culturais da instituição. Sem a utilização da tecnologia da informação como ferramenta, provavelmente não se implantariam os novos modelos de gestão adotados pela Sefaz, mas se observou que a tecnologia, sozinha, não faz o milagre da mudança, sendo necessário todo um conjunto de esforços e um trabalho paralelo com outros fatores de mudança.Palavras-chave: mudança organizacional, informação tecnológica, Secretaria da Fazenda do Estado de Pernambuco
Mapeamento da oferta de capacitação nas escolas de governo no Brasil: gestão da informação para fortalecimento da gestão pública
Authors: Ferrarezi Elisabete , Tomacheski João Alberto 
Published: February 2020

Esse texto tem por objetivo apresentar os resultados parciais do projeto “Mapeamento da Oferta de Capacitação nas Escolas de Governo” e debater as possibilidades que se abrem para a gestão do conhecimento e para o gerenciamento das informações estratégicas visando à tomada de decisões e a otimização dos recursos disponíveis para a capacitação. O projeto mapeamento tem por objetivo coletar dados da oferta existente de capacitação em escolas de governo brasileiras, em nível municipal, estadual e federal. Foi concebido em três fases: coleta das informações cadastrais e sobre a disponibilidade de cursos; construção do vocabulário controlado e classificação dos cursos; e transposição dessas informações para um sistema de informações com interface web: o Sistema Mapa. O Sistema Mapa, se efetivamente incorporado e utilizado, poderá constituir um sistema de informação que auxilie os gestores e dirigentes a planejar e realizar planos de capacitação, utilizando de forma eficiente a oferta existente nas escolas de governo. Além disso, poderá contribuir para melhor coordenação das atividades de capacitação, incentivo à complementaridade, redução de duplicidades e incentivo à ampliação da comunicação entre as instituições da Rede.Palavras-chave: Mapeamento da oferta de capacitação - Rede Nacional de Escolas de Governo – Sistema Mapa – formação de servidores públicos.
Impact of Motivational Interviewing on Self-Management in Patients With Type 2 Diabetes: Protocol for a Pilot Randomized Controlled Trial
Authors: Wong Man Kin , Cheng Sai Yip Ronald , Chu Tsun Kit , Lam Fung Yee , Lai Shiu Kee , Wong Kai Chung , Liang Jun 
Published: February 2020

Background
The nonpharmacological approach to diabetic control in patients with diabetes focuses on a healthy diet, physical activity, and self-management. Therefore, to help patients change their habits, it is essential to identify the most effective approach. Many efforts have been devoted to explain changes in or adherence to specific health behaviors. Such efforts have resulted in the development of theories that have been applied in prevention campaigns and include brief advice and counseling services. Within this context, motivational interviewing (MI) has proven to be effective in changing health behaviors for specific cases. However, stronger evidence is needed on the effectiveness of MI in treating chronic pathologies such as diabetes.

Objective
This study will obtain preliminary data on the impact of a nurse-led MI intervention in improving glycemic control, as well as clinical, psychosocial, and self-care outcomes for individuals with type 2 diabetes mellitus when compared with usual care, with the aim of improving diabetic control in patients with diabetes.

Methods
An open, two-arm, parallel, randomized controlled, pilot exploratory trial will be performed. Two government outpatient clinics in the New Territories West Cluster in Hong Kong will be involved. In total, 20 to 25 participants will be invited in each arm. Intervention participants will receive face-to-face MI interventions in addition to their usual care from the clinic. Control participants will only receive usual care. Outcomes are assessed at baseline, 6 months, and 12 months. The primary outcome measure is glycated hemoglobin levels. Secondary outcomes include blood pressure, BMI, hip and waist circumference, fasting blood, and psychosocial and self-care measures.

Results
This study is currently underway with funding support from the Hong Kong College of Family Physician Research Seed Fund 2017.

Conclusions
MI skills constitute the main strategies primary care nurses use on their patients. Having economical, simple, effective, and applicable techniques is essential for primary care professionals to help their patients change their lifestyle and improve their health. This study will provide scientific evidence on the effectiveness of MI. It will be performed with strict control over the data collection, ensuring the maintenance of therapeutic integrity.

Trial Registration
Centre for Clinical Research and Biostatistics CUHK_CCRB00614; https://tinyurl.com/v9awzk6

International Registered Report Identifier (IRRID)
DERR1-10.2196/15709
FORMULATION AND EVALUATION OF METFORMIN HYDROCHLORIDE LOADED FLOATING MICROSPHERES
Authors: KESHARVANI SHIKHA , JAISWAL PANKAJ KUMAR , MUKERJEE ALOK , SINGH AMIT KUMAR 
Published: February 2020

Objective: The main objective of this study was to develop and evaluate the eudragit and HPMC coated metformin hydrochloride floating microspheres, in which HPMC helps in floating and eudragit as a coating material for a site-specific drug release in a controlled manner and the active moiety metformin used as anti-hyperglycemic agent.
Methods: The floating microsphere was prepared by the solvent evaporation method incorporating metformin as a model drug. The prepared floating microsphere were characterized for particle size, %yield, drug loading and entrapment efficiency, compatibility study, %buoyancy, surface morphology and In vitro drug release and release kinetics.
Results: The result metformin loaded floating microsphere was successfully prepared and the particle size range from 397±23.22 to 595±15.82 µm, the entrapment efficiency range from 83.49±1.33 to 60.02±1.65% and drug loading capacity range from 14.3±0.54 to 13.31±0.47% and %buoyancy range from 85.67±0.58 to 80.67±1.15%. The FT-IR and X-RD analysis confirmed that no any interaction between drug and excipient, and surface morphology confirmed those particles are sphere. The floating microsphere show maximum 96% drug release in pH 0.1N HCL and follow the Korsmeyer peppas model of the super case-2 transport mechanism.
Conclusion: These results suggest that metformin loaded floating microspheres could be retain in stomach for long time and give site specific drug release in controlled manner.