bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of preoperative antiplatelet or anticoagulation therapy on hemorrhagic complications in patients with traumatic brain injury undergoing craniotomy or craniectomy
Authors: Greuter Ladina , Ullmann Muriel , Mariani Luigi , Guzman Raphael , Soleman Jehuda 
Published: November 2019

OBJECTIVETraumatic brain injury (TBI) is common among the elderly, often treated with antiplatelet (AP) or anticoagulation (AC) therapy, creating new challenges in neurosurgery. In contrast to elective craniotomy, in which AP/AC therapy is mostly discontinued, in TBI usually no delay in treatment can be afforded. The aim of this study was to analyze the effect of AP/AC therapy on postoperative bleeding after craniotomy/craniectomy in TBI.METHODSPostoperative bleeding rates in patients treated with AP/AC therapy (blood thinner group) and in those without AP/AC therapy (control group) were retrospectively compared. Furthermore, univariate and multivariate analyses were conducted to identify risk factors for postoperative bleeding. Lastly, a proportional Cox regression analysis comparing postoperative bleeding events within 14 days in both groups was performed.RESULTSOf 143 consecutive patients undergoing craniotomy/craniectomy for TBI between 2012 and 2017, 47 (32.9%) were under AP/AC treatment. No significant difference for bleeding events was observed in univariate (40.4% blood thinner group vs 36.5% control group; p = 0.71) or Cox proportional regression analysis (log rank χ2 = 0.29, p = 0.59). Patients with postoperative bleeding showed a significantly higher mortality rate (p = 0.035). In the univariate analysis, hemispheric lesion, acute subdural hematoma, hematological disease, greater extent of midline shift, and pupillary difference were significantly associated with a higher risk of postoperative bleeding. However, in the multivariate regression analysis none of these factors showed a significant association with postoperative bleeding.CONCLUSIONSPatients treated with AP/AC therapy undergoing craniotomy/craniectomy due to TBI do not appear to have increased rates of postoperative bleeding. Once postoperative bleeding occurs, mortality rates rise significantly.
A combination of mesenchymal stem cells and scaffolds promotes motor functional recovery in spinal cord injury: a systematic review and meta-analysis
Authors: Yousefifard Mahmoud , Nasseri Maleki Solmaz , Askarian-Amiri Shaghayegh , Vaccaro Alexander R. , Chapman Jens R. , Fehlings Michael G. , Hosseini Mostafa , Rahimi-Movaghar Vafa 
Published: November 2019

OBJECTIVEThere is controversy about the role of scaffolds as an adjunctive therapy to mesenchymal stem cell (MSC) transplantation in spinal cord injury (SCI). Thus, the authors aimed to design a meta-analysis on preclinical evidence to evaluate the effectiveness of combination therapy of scaffold + MSC transplantation in comparison with scaffolds alone and MSCs alone in improving motor dysfunction in SCI.METHODSElectronic databases including Medline, Embase, Scopus, and Web of Science were searched from inception until the end of August 2018. Two independent reviewers screened related experimental studies. Animal studies that evaluated the effectiveness of scaffolds and/or MSCs on motor function recovery following experimental SCI were included. The findings were reported as standardized mean difference (SMD) and 95% confidence interval (CI).RESULTSA total of 34 articles were included in the meta-analysis. Analyses show that combination therapy in comparison with the scaffold group alone (SMD 2.00, 95% CI 1.53–2.46, p < 0.0001), the MSCs alone (SMD 1.58, 95% CI 0.84–2.31, p < 0.0001), and the nontreated group (SMD 3.52, 95% CI 2.84–4.20, p < 0.0001) significantly improved motor function recovery. Co-administration of MSCs + scaffolds only in the acute phase of injury (during the first 3 days after injury) leads to a significant recovery compared to scaffold alone (SMD 2.18, p < 0.0001). In addition, the cotransplantation of scaffolds with bone marrow–derived MSCs (SMD 1.99, p < 0.0001) and umbilical cord–derived MSCs (SMD 1.50, p = 0.001) also improved motor function following SCI.CONCLUSIONSThe findings showed that scaffolds + MSCs is more effective than scaffolds and MSCs alone in improving motor function following SCI in animal models, when used in the acute phase of injury.
Treatment approaches for Scheuermann kyphosis: a systematic review of historic and current management
Authors: Huq Sakibul , Ehresman Jeffrey , Cottrill Ethan , Ahmed A. Karim , Pennington Zach , Westbroek Erick M. , Sciubba Daniel M. 
Published: November 2019

OBJECTIVEScheuermann kyphosis (SK) is an idiopathic kyphosis characterized by anterior wedging of ≥ 5° at 3 contiguous vertebrae managed with either nonoperative or operative treatment. Nonoperative treatment typically employs bracing, while operative treatment is performed with either a combined anterior-posterior fusion or posterior-only approach. Current evidence for these approaches has largely been derived from retrospective case series or focused reviews. Consequently, no consensus exists regarding optimal management strategies for patients afflicted with this condition. In this study, the authors systematically review the literature on SK with respect to indications for treatment, complications of treatment, differences in correction and loss of correction, and changes in treatment over time.METHODSUsing PubMed, Embase, CINAHL, Web of Science, and the Cochrane Library, all full-text publications on the operative and nonoperative treatment for SK in the peer-reviewed English-language literature between 1950 and 2017 were screened. Inclusion criteria involved fully published, peer-reviewed, retrospective or prospective studies of the primary medical literature. Studies were excluded if they did not provide clinical outcomes and statistics specific to SK, described fewer than 2 patients, or discussed results in nonhuman models. Variables extracted included treatment indications and methodology, maximum pretreatment kyphosis, immediate posttreatment kyphosis, kyphosis at last follow-up, year of treatment, and complications of treatment.RESULTSOf 659 unique studies, 45 met our inclusion criteria, covering 1829 unique patients. Indications for intervention were pain, deformity, failure of nonoperative treatment, and neural impairment. Among operatively treated patients, the most common complications were hardware failure and proximal or distal junctional kyphosis. Combined anterior-posterior procedures were additionally associated with neural, pulmonary, and cardiovascular complications. Posterior-only approaches offered superior correction compared to combined anterior-posterior fusion; both groups provided greater correction than bracing. Loss of correction was similar across operative approaches, and all were superior to bracing. Cross-sectional analysis suggested that surgeons have shifted from anterior-posterior to posterior-only approaches over the past two decades.CONCLUSIONSThe data indicate that for patients with SK, surgery affords superior correction and maintenance of correction relative to bracing. Posterior-only fusion may provide greater correction and similar loss of correction compared to anterior-posterior approaches along with a smaller complication profile. This posterior-only approach has concomitantly gained popularity over the combined anterior-posterior approach in recent years.
Hematological Profile and Serum Potassium Level in Patients of Chronic Renal Failure at a Tertiary Health Care Center
Authors: Yogi Jai Prakash , Fiza Bushra , Godara Suraj , Sinha Maheep 
Published: November 2019

Background: Chronic Kidney Disease (CKD) can be defined as an estimated glomerular Filtration Rate (eGFR) of less than ml/min/1.73 m2 for a minimum period of three months. CKD is commonly associated with various hematological abnormalities especially anemia. Aim: The present study was planned to assess the hematological variations in CKD patients as compared to healthy subjects. Method: Fifty patients diagnosed with CKD were enrolled for the study. Fifty age and sex-matched healthy subjects constituted the control group. Result: On comparison of the hematological profile, it was observed that all enrolled CKD patients were anemic with hemoglobin (Hb) less than 13g/dL in males and less than 12 g/dL in females. The mean Hb levels were as low as 7.50 + 1.55 g/dL (P< 0.0001). Correspondingly, the total RBC count of CKD patients was also low. It was also observed that the platelet count was slightly low among CKD patients. However, the mean level was comparable with the control group (P=NS). On further analysis, it was observed that among fifty CKD patients, 46% (n=23) suffered from severe anemia i.e. Hb < 7 gm/dL whereas 48% had moderate anemia i.e. Hb between 7-9.9 gm/dL. However, only 12 % (n=6) CKD patients suffered from thrombocytopenia i.e. platelets count < 1.50 lack/ cmm. Conclusion: Hematological abnormalities may lead to several associated morbidities and may pose a challenge for the maintenance of overall health status for CKD patients. Hence, there is a need to monitor the hematological profile of CKD patients especially those on dialysis so that any abnormality can be detected and managed accordingly.
Keywords: Chronic kidney disease, Anemia, Hematological changes, Potassium, Platelets.
PARENTAL PERCEPTION OF LOW IQ FACTS OR FICTION: RETROSPECTIVE DATA FROM CLINIC IN SEMI RURAL MAHARASHTRA
Authors: Tamboli Suchit Suresh , Joglekar Charudatt , Desle Vasant , Tamboli Anvesh 
Published: November 2019

Objective: To study the association between physical and psychological problems perceived by parents and the IQ of their children. Methods: We studied 981 children in the child development center at Ahmednagar. Median age at followup was 7.8y (Q25=5.6y and Q75=10.4y, Babies underwent IQ evaluation by Binet Kamat scale (n=981); also their physical and psychological problems perceived by parents were documented. We categorized children into 4 categories using a number of problems (physical and psychological separately) viz 1 (no problem), 2 (1 problem), 3 (2 problems), 4 (>2 problems). When we looked at physical problem data, 555 (56.6%) had no problem, 251 (25.6%) had 1, 117 (11.9%) had 2, and the remaining 58 (5.9%) had more than 2. For psychological problems like not interested in studies, speech problems don't remember, don't understand, cannot concentrate, fears, etc. The distribution was 221 (22.5%), 212 (21.6%), 222 (22.6%) and 326 (33.3%) respectively. Result: The increasing trend of mean IQ for physical problem parameters from nil to >2 categories and decreasing prevalence of low IQ using the Binet Kamat scale were not significant. However, for psychological problems, the decreasing and statistically significant trend (p=0.000) was present for mean IQ, and a significant increasing trend (p=0.029) for the prevalence of low IQ was observed. Conclusion: Psychological problems were associated with IQ. Numbers of problems were inversely correlated with IQ.
Keywords: Parental Perception; Low IQ; Behavioral Problems; Physical Problems.
About Innovative Content of Subject-Oriented Pedagogical Education
Authors: Asadullin R. M. 
Published: November 2019

The continuous modernization of the education system makes the problems of the quality of teacher training increasingly relevant. Moreover, the measures taken to improve the system of teacher education are largely confined to the introduction of new organizational and managerial mechanisms and practically do not affect the internal content and technological structure of the teacher training process.Modern pedagogical universities are constantly looking for innovative models of training teachers that will be able to solve non-standard social and professional tasks. However, recent studies in this area do not fully take into account the nature of pedagogical activity and conditions of its formation. Thus, the need arises for a special study of the processes and means of updating the content and technologies of teacher training in order to control the level of students’ professional competencies development, as required by educational and professional standards. This means the creation of a special educational system in a pedagogical university, which can provide a harmonious and synchronous mastering by future specialists of both subject knowledge and methods of pedagogical activity.The article provides a theoretical study aimed at identifying key patterns of designing a new content for teacher education, the basis of which is the formation of a future teacher as a subject of his own professional activity. The author describes the experience of using a subject-oriented model of education, implemented at Bashkir State Pedagogical University n.a. M. Akmulla. The effectiveness of this model is confirmed by the high level of students’ mastery of designing methods and constructing the educational process, as well as their positive experience in the implementation of educational activities.
Readiness of Technical University Students to Entrepreneurship Activity
Authors: Minin M. G. , Politsinskaya E. V. , Lizunkov V. G. 
Published: November 2019

The article raises the problem of the formation of entrepreneurial competencies in response to the current situation in the country’s economy, which arose due to the lack of specialists capable of organizing innovation and technology business in the Territories of advanced socio-economic development (TOSED).The authors have analyzed the professional preferences of graduates of the National Research Tomsk Polytechnic University (Russia), the University of Zagreb (Croatia), and the University of Lyon (France) and identified the reasons why graduates do not create their own business. In order to determine the necessary cluster of entrepreneurial competencies of university graduates with basic technical education, a survey involving the representatives of Russian and foreign companies working in Russia, including TOSED residents, was conducted. As a result, the authors have received a list of key entrepreneurial competencies necessary for entrepreneurial activities and the formation of graduate competence in the field of management and business.The authors believe that for the formation of entrepreneurial competence, certain conditions must be created in the educational process for preparing a student for entrepreneurial activities, in particular a number of disciplines (entrepreneurship, technological entrepreneurship, project management, business planning) should be included in the curricula; interactive design training methods aimed to develop graduate’s readiness to create their own business should be applied. It is also necessary to provide an the interaction between universities and business structures, which are mostly the residents of TOSED.
HIV pozitif hastalarda HHV-6 prevalansı ve varyant tiplerinin belirlenmesi
Authors: TARHAN Gülnur , YILMAZ Neziha , CESUR Salih 
Published: November 2019

Amaç: Bu çalışmanın amacı HIV enfeksiyonu pozitif
saptanan hastalarda HHV-6 DNA sıklığının, HHV-6 DNA’sı pozitif saptanan
olgularda ise HHV-6 varyant türünün (varyant A veya varyant B) belirlenmesiydi.Gereç
ve Yöntem: Çalışmaya 20 HIV pozitif hasta
ile 57 HIV negatif sağlıklı birey dahil edildi. Hasta ve kontrol grubunda HHV-6
DNA’sı polimeraz zincir reaksiyonu (PZR) ile araştırıldı. HHV-6 DNA pozitif
saptanan olgularda HHV-6 varyant türü restriksiyon parça uzunluğu polimorfizmi (restriction
fragment lenght polymorphisim: RFLP) ile
araştırıldı. İstatistiksel değerlendirme SPSS programında yapıldı, p≤0.05
istatistiksel olarak anlamlı kabul edildi. Bulgular: HIV pozitif hastalarda HHV-6 DNA pozitifliği %45
(9/20), HIV negatiflerde ise %33,3 (19/57) olarak belirlendi. Toplamda
pozitiflik oranı %36,3 (28/77) idi. HIV pozitif hastalarda HHV-6 varyant B
saptanırken, varyant A saptanmadı. Sonuç: HIV pozitif hastalarda HHV-6 seropozitifliği ve
varyant tiplerinin öneminin belirlenmesi için daha fazla sayıda olgu içeren başka
klinik çalışmalara gereksinim olduğu görüşündeyiz.
Dampak Pulau Reklamasi terhadap Sedimentasi dan Potensi Perkembangan Mangrove Di Pesisir Teluk Jakarta (Muara Angke)
Authors: Putra Indra Setya 
Published: November 2019

Mangroves in Indonesia have a large enough area, but in the last 3 decades the area has been reduced to 40%. Besides having a function as a coastal protector, mangroves are also able to maintain the quality of the waters around it. Currently, the construction of a reclamation island in Jakarta Bay is being carried out which will have an impact on the surrounding mangrove forests. Therefore, the purpose of this study was to identify the impact of island reclamation in Jakarta Bay on sedimentation and mangrove growth in surrounding area. This research was conducted with literature studies, vegetation analysis, water quality analysis and also spatial analysis with WorldView-2 satellite imagery. The results showed that the mangrove forests on the coast of North Jakarta, especially in the Muara Angke area tend to increase, especially in the reclaimed island area. The mangrove stands increase by approximately 1.32 ha / year. The density and stem diameters vary in 5 locations. Oxygen levels at the study site are very low but the existing mangrove forests can absorb dissolved heavy metals. The results of the study also show that the area that has the potential to be planted with mangroves is 30 ha. Overall, the sedimentation process helps expand mangrove forests naturally while the bad quality of water does not significantly affect the development of mangroves. On the contrary, the existing mangrove is able to keep the stability of theÂ water quality in surrounding area.
Micro-Reconciliation as a Pathway for Transformative Change
Authors: Tait Caroline Lily , Mussell William , Henry Robert 
Published: November 2019

This paper introduces the concept of micro-reconciliation as a pragmatic action to support cultural safety and humility work. Similar to cultural safety and humility, micro-reconciliation practices aim to challenge and diminish racism, inequality and inequity experienced by Indigenous peoples. In arguing for changes to the human service sector, micro-reconciliation exists at the intersections between entrenched structural racism and the psychological and emotional roots of discrimination that play out in every day service delivery. Three organizing practices are discussed; acknowledment, witnessing and moral courage, as the basis of micro-reconciliaion work and the advancement of cultural safety and reconciliaton.
Pengaruh Motivasi Terhadap Minat Berwirausaha Mahasiswa Program Studi Administrasi Bisnis Universitas Telkom
Authors: Wijayangka Candra , Kartawinata Budi Rustandi , Novrianto Bagus 
Published: November 2019

Minat berwirausaha merupakan pemusatan perhatian pada wirausaha karena adanya rasa suka dan disertai keinginan mempelajari, mengetahui dan membuktikan lebih lanjut terhadap wirausaha. Minat berwirausaha muncul karena adanya pengetahuan dan informasi mengenai kewirausahaan yang kemudian dilanjutkan untuk berpartisipasi secara langsung dalam rangka mencari pengalaman dan akhirnya timbul keinginan untuk memperhatikan pengalaman yang telah didapatkan tersebut. Serta mempunyai perasaan senang dan mempunyai keinginan untuk terlibat dalam kegiatan pengambilan resiko, untuk menjalankan bisnis atau usaha sendiri dengan memanfaatkan peluang-peluang bisnis yang ada, dan menciptakan bisnis baru dengan pendekatan inovatif.Salah satu faktor yang mempengaruhi timbulnya Minat Berwirausaha adalah Motivasi Berwirausaha.
Penelitian ini bertujuan untuk mengetahui pengaruh Motivasi Berwirausaha terhadap Minat Berwirausahapada mahasiswa Administrasi Bisnis angkatan 2015 Universitas Telkom. Metode yang digunakan dalam penelitian ini adalah kuantitatif dengan jenis penelitian analisis deskriptif. Responden dalam penelitian ini adalah 74 mahasiswa Administrasi Bisnis angkatan 2015 Universitas Telkom dengan metode pengambilansampel yaitu sampel jenuh.
Hasil penelitian menunjukkan bahwa tanggapan responden terhadap Motivasi Berwirausahadalam kategori baik dengan skor 79,0%. Dan tanggapan responden terhadap Minat Berwirausaha dalam kategoribaik dengan skor 80,9%. Kesimpulan penelitian ini adalah Motivasi Berwirausahaberpengaruh dan signifikan secara positif terhadap Minat Berwirausahadengan skor 43,5%. Hasil tersebut dapat diartikan bahwa dengan meningkatnya Motivasi Berwirusaha pada mahasiswaakan berpengaruh untuk meningkatkan Minat Berwirausaha.
Strategi Pemasaran Sepeda Motor Merek Honda Tipe Matic (Studi Kasus PT. HOHO Pekanbaru)
Authors: Anggraini Nia 
Published: November 2019

Penelitian ini dilakukan di Kota Pekanbaru dengan tujuan untuk mengetahui kebijakan yang harus dilakukan perusahaan dalam meningkatkan pemasaran sepeda motor merek Honda tipe matic khususnya beat pada PT. HOHO Pekanbaru. Dan hasil penelitian ini diharapkan dapat bermanfaat sebagai bahan informasi bagi pembaca dan bahan acuan bagi pihak-pihak yang berkepentingan dengan masalah strategi pemasaran, serta sebagai pengembangan masa depan perusahaan distributor sepeda motor merek Honda.
Metode analisa data yang digunakan dalam penelitian ini adalah analisa deskriptif, yaitu suatu metode penelitian yang berusaha menggambarkan atau menganalisis suatu gejala, peristiwa yang terjadi pada masalah aktual atau pencarian fakta dengan interpretasi yang tepat sebagaimana adanya, tetapi tidak digunakan untuk membuat kesimpulan yang lebih luas. Dalam metode deskriptif ini hanyalah memaparkan situasi atau peristiwa faktual mengenai fakta-fakta serta hubungan antar fenomena yang diselidiki.
Dari hasil penelitian diperoleh bahwa PT. HOHO Pekanbaru telah berhasil mendistribusikan produknya berupa sepeda motor merek Honda beat tipe matic dari segi kelengkapan fungsi (fitur), desain, pilihan warna, keunggulan, dan daya tahan sangat unggul dan lengkap, telah berhasil menetapkan harga sesuai dengan kebutuhan konsumen dalam persaingan dan biaya kemudian telah melakukan promosi produk dengan baik, seperti advertising, sales promotion, ataupun personal selling. PT. HOHO Pekanbaru juga dinilai sudah mampu bersaing secara sangat baik dari segi persaingan merek jika dibandingkan dengan merek sepeda motor lainnya.
Corporate Governance terhadap Tax Avoidance pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia
Authors: Sumantri Farid Addy , Anggraeni Rr. Dian , Kusnawan Agus 
Published: November 2019

Tujuan dari penelitian ini adalah untuk menguji bagaimana Pengaruh Dewan Direksi Independen, Kepemilikan Manajemen dan Komite Audit, terhadap Penghidaran Pajak pada Perusahaan Industri metal dan sejenisnya yang terdaftar di Bursa Efek Indonesia tahun 2012-2016. Pengukuran Tax Avoidance menggunakan CETR.
Sampel yang digunakan dalam penelitian ini sebanyak 45 sampel yang terdiri dari Sembilan perusahaan selama 5 tahun. Jenis penelitian yang mengunakan metode kuantitatif meupakan adalah dengan menggunakan pendekatan non random sampling. Teknis analisis yang digunakan adalah regresi linier berganda.
Hasil penelitian menunjukkan Proporsi Dewan Komisaris berpengaruh terhadap penghindaran pajak (tax avoidance) dengan nilai signifikannya sebesar 0,033 < 0,050). Hasil penelitian ini menyimpulkan bahwa H1 yang diajukan dalam penelitian diterima dan terbukti, Komite Audit berpengaruh terhadap penghindaran pajak (tax avoidance) dengan nilai signifikannya sebesar 0,018 < 0,050) dan Kepemilikan Manajemen tidak berpengaruh terhadap penghindaran pajak (tax avoidance) dengan nilai signifikannya sebesar 0,149 > 0,050).