bluuebunny/crossref_metadata_2025_split huggingface dataset:
Classification of neuroendocrine neoplasms: lights and shadows
Authors: La Rosa Stefano , Uccella Silvia 
Published: November 2020

AbstractNeuroendocrine neoplasms (NENs) are a heterogeneous group of neoplastic proliferations showing different morphological features, immunophenotype, molecular background, clinical presentation, and outcome. They can virtually originate in every organ of the human body and their classification is not uniform among different sites. Indeed, as they have historically been classified according to the organ in which they primarily arise, the different nomenclature that has resulted have created some confusion among pathologists and clinicians. Although a uniform terminology to classify neuroendocrine neoplasms arising in different systems has recently been proposed by WHO/IARC, some issues remain unsolved or need to be clarified. In this review, we discuss the lights and shadows of the current WHO classifications used to define and characterize NENs of the pituitary gland, lung, breast and those of the head and neck region, and digestive and urogenital systems.
Application of Fe(VI) in abating contaminants in water: State of art and knowledge gaps
Authors: Wang Shuchang , Shao Binbin , Qiao Junlian , Guan Xiaohong 
Published: November 2020

AbstractThe past two decades have witnessed the rapid development and wide application of Fe(VI) in the field of water de-contamination because of its environmentally benign character. Fe(VI) has been mainly applied as a highly efficient oxidant/disinfectant for the selective elimination of contaminants. The in situ generated iron(III) (hydr)oxides with the function of adsorption/coagulation can further increase the removal of contaminants by Fe(VI) in some cases. Because of the limitations of Fe(VI) per se, various modified methods have been developed to improve the performance of Fe(VI) oxidation technology. Based on the published literature, this paper summarized the current views on the intrinsic properties of Fe(VI) with the emphasis on the self-decay mechanism of Fe(VI). The applications of Fe (VI) as a sole oxidant for decomposing organic contaminants rich in electron-donating moieties, as a bi-functional reagent (both oxidant and coagulant) for eliminating some special contaminants, and as a disinfectant for inactivating microorganisms were systematically summarized. Moreover, the difficulties in synthesizing and preserving Fe(VI), which limits the large-scale application of Fe (VI), and the potential formation of toxic byproducts during Fe(VI) application were presented. This paper also systematically reviewed the important nodes in developing methods to improve the performance of Fe(VI) as oxidant or disinfectant in the past two decades, and proposed the future research needs for the development of Fe(VI) technologies.
Recent Trends in U.S. Childbearing Intentions
Authors: Hartnett Caroline Sten , Gemmill Alison 
Published: November 2020

Abstract
The U.S. period total fertility rate has declined steadily since the Great Recession, reaching 1.73 children in 2018, the lowest level since the 1970s. This pattern could mean that current childbearing cohorts will end up with fewer children than previous cohorts, or this same pattern could be an artifact of a tempo distortion if individuals are simply postponing births they plan to eventually have. In this research note, we use data on current parity and future intended births from the 2006–2017 National Survey of Family Growth to shed light on this issue. We find that total intended parity declined (from 2.26 in 2006–2010 to 2.16 children in 2013–2017), and the proportion intending to remain childless increased slightly. Decomposition indicates that the decline was not due to changes in population composition but rather changes in the subgroups’ rates themselves. The decline in intended parity is particularly notable at young ages and among those who are Hispanic. These results indicate that although tempo distortion is likely an important contributor to the decline in TFR, it is not the sole explanation: U.S. individuals are intending to have fewer children than their immediate predecessors, which may translate into a decline in cohort completed parity. However, the change in intended parity is modest, and average intended parity remains above two children.
Impact of Hurricane Harvey on the Growth of Low Income, Ethnic Minority Adolescents
Authors: Arlinghaus Katherine R. , Gorniak Stacey L. , Hernandez Daphne C. , Johnston Craig A. 
Published: November 2020

AbstractObjective:This study examined the differential impact of Hurricane Harvey on adolescent standardized Body Mass Index (zBMI), physical activity, diet, and perceived stress.Methods:Prior to Hurricane Harvey, 175 ethnic minority adolescents were recruited from an independent school district in Houston. Height and weight were directly measured. The School Physical Activity and Nutrition Questionnaire assessed diet and physical activity. Stress was assessed with the Perceived Stress Scale. High hurricane impact was classified as at least 1 affirmative response to house damage, rescue, displacement, or going without food, water, or medicine. Repeated measures such as ANCOVA models were developed to assess differences in zBMI, physical activity, diet, and stress between the hurricane impact groups. Regression models were used to assess stress as a mediator of the hurricane impact and zBMI change relationship.Results:Students who were highly impacted by the hurricane had a greater decrease in zBMI than those less impacted from pre-hurricane to 15 weeks post-hurricane (95% CI 0.02 to 0.25, p<0.05). Physical activity and diet did not differ by impact. Perceived stress at 3 weeks post-hurricane mediated the impact and zBMI change relationship (β=-0.04 95% CI -0.12 to -0.002).Conclusion:The decrease in zBMI among highly impacted students warrants further monitoring. Perceived stress, immediately following the hurricane, impacted student growth months later.
Why No True Reliabilist Should Endorse Reliabilism
Authors: Ahlstrom-Vij Kristoffer , Dunn Jeffrey S. 
Published: November 2020

AbstractCritics have recently argued that reliabilists face trade-off problems, forcing them to condone intuitively unjustified beliefs when they generate lots of true belief further downstream. What these critics overlook is that reliabilism entails that there are side-constraints on belief-formation, on account of which there are some things you should not believe, even if doing so would have very good epistemic consequences. However, we argue that by embracing side-constraints the reliabilist faces a dilemma: she can either hold on to reliabilism, and with it aforementioned side-constraints, but then needs to explain why we should allow the pursuit of justification to get in the way of the acquisition of true belief; or she can deny that there are side-constraints – and in effect give up on reliabilism. We'll suggest that anyone moved by the considerations that likely attract people to reliabilism in the first place – the idea the true belief is good, and as such should be promoted – should go for the second horn, and instead pursue a form of epistemic utilitarianism.
Blackcurrant (Ribes nigrum) lowers sugar-induced postprandial glycaemia independently and in a product with fermented quinoa: a randomised crossover trial
Authors: Lappi Jenni , Raninen Kaisa , Väkeväinen Kati , Kårlund Anna , Törrönen Riitta , Kolehmainen Marjukka 
Published: November 2020

AbstractBerries rich in anthocyanins have beneficial effects on postprandial glycaemia. We investigated whether blackcurrant (75 g in a portion) independently and in a product with fermented quinoa induced similar effects on the sugar-induced postprandial glucose metabolism as observed before with 150 g of blackcurrant. Twenty-six healthy subjects (twenty-two females and four males) consumed four test products after fasting overnight in a randomised, controlled crossover design. Each test product portion contained 31 g of available carbohydrates and had similar composition of sugar components: 300 ml water with sucrose, glucose and fructose (SW; reference), blackcurrant purée with added sugars (BC), a product consisting of the blackcurrant purée and a product base with fermented quinoa (BCP) and the product base without blackcurrant (PB). Blood samples were collected at 0, 15, 30, 45, 60, 90, 120 and 180 min after eating each test product to analyse the concentrations of glucose, insulin and NEFA. In comparison with the SW, the intake of both the BC and BCP resulted in reduced glucose and insulin concentrations during the first 30 min, a more balanced decline during the first hour and improved glycaemic profile. The BCP induced more efficient effects than the BC due to the product base with fermented quinoa. A rebound of NEFA after the sugar-induced hypoglycaemic response was attenuated at the late postprandial phase by the BC and BCP. In conclusion, we showed that 75 g of blackcurrant and the product with fermented quinoa were able to lower postprandial glycaemia and insulinaemia.
Timed versus untimed recognition of L2 collocations: Does estimated proficiency modulate congruency effects?
Authors: Sonbul Suhad , El-Dakhs Dina 
Published: November 2020

AbstractCongruency (the availability of a direct first language translation) and level of proficiency have been reported among the most important determinants of second language collocation processing. However, only very few studies looked at the interaction between the two determinants, and none of these directly compared untimed collocation recognition assessed through traditional tests to timed recognition evident in psycholinguistic tasks. The current study administered both types of form recognition measures to 228 female Saudi English as a foreign language learners in two separate experiments: a traditional multiple-choice test (Experiment 1) and a timed acceptability judgment task (Experiment 2). Experiment 2 also tested 37 native speakers of English as a baseline for comparison. Congruency, estimated proficiency (vocabulary test scores), and the interaction between the two were evaluated as predictors of untimed and timed recognition through mixed-effects modeling. Results showed that congruency and estimated proficiency had a clear effect on untimed and timed recognition. More interesting, the effect of proficiency was clearer on timed recognition with a gradual decrease in the first language effect as proficiency increased getting closer to nativelike collocation processing. Results have implications for second language collocation learning and testing.
The experience of caring for an older relative in Chile: going beyond the burden of care
Authors: Palacios Josefa , Pérez-Cruz Pedro , Webb Andrew 
Published: November 2020

AbstractCare in Chile, as in most Latin American countries, remains largely the responsibility of female family members in informal arrangements with little government support. The analysis of caring for a dependent older person has commonly been approached from the burden of care perspective, focusing on the tasks carried out, the time spent providing care and the negative (burdensome) consequences for the care-giver. This study reveals the daily experiences of family care-givers of older people through a thematic data analysis of 42 interviews with main family carers of an older person as experienced by the carers themselves. Findings highlight the complex nature of care work. Tasks carried out do not necessarily relate to the intensity of the care experience or a negative experience. Care-givers can work long hours providing care and still feel comfortable and find the experience emotionally rewarding. Care-givers might also carry out only a few tasks and experience pressure. The broader social and economic context can generate constraints that make a specific set of tasks easier or harder on the carer, but these contextual factors do not fully explain the experience of care. Relations, and particularly those that carry an emotional component such as the carer-older person, carer-siblings and carer-spouse, must be considered alongside the tasks and the difficulties or potential constraints of the context to understand the care experience.
DEUDA, PAPELES Y COMPROMISOS EN LA CONSTRUCCIÓN DEL CRÉDITO PÚBLICO. LA CAJA NACIONAL DE FONDOS DE SUD AMÉRICA (BUENOS AIRES, 1818–1821)
Authors: Wasserman Martín L. E. 
Published: November 2020

ABSTRACTThe South American Funds National Exchequer was established in 1818 to contribute to the consolidation of the public debt of Buenos Aires. It was the first financial innovation since the revolutionary outbreak in Buenos Aires, and its failure allowed the authorities to understand the limits of the fiscal and financial commitment they proposed by means of that institution. Its suppression, in 1821, offered an antecedent to develop a deep reform of the financial institutional matrix of Buenos Aires, based on the Public Credit office, the Amortization Exchequer and the Bank of Buenos Aires. The South American Funds National Exchequer was, thus, the first movement in the negotiation on the terms of the financial commitment assumed by the nascent State. This paper analyzes the 973 accounting entries of the institution, providing an interpretation of that failure and its importance for the course of public finances in Buenos Aires.
Preventive care and medical homes among US children with heart conditions
Authors: Broughton Amber , Riehle-Colarusso Tiffany , Nehl Eric , Riser Aspen P. , Farr Sherry L. 
Published: November 2020

AbstractWithin a medical home, primary care providers can identify needs, provide services, and coordinate care for children with heart conditions. Using parent-reported data from the 2016–2017 National Survey of Children’s Health, we examined receipt of preventive care in the last 12 months and having a medical home (care that is accessible, continuous, comprehensive, family-centred, coordinated, compassionate, and culturally effective) among US children aged 0–17 years with and without heart conditions. Using the marginal predictions approach to multivariable logistic regression, we examined associations between presence of a heart condition and receipt of preventive care and having a medical home. Among children with heart conditions, we evaluated associations between sociodemographic and health characteristics and receipt of preventive care and having a medical home. Of the 66,971 children included, 2.2% had heart conditions. Receipt of preventive care was reported for more children with heart conditions (91.0%) than without (82.7%) (adjusted prevalence ratio = 1.09, 95% confidence interval: 1.05–1.13). Less than half of children with heart conditions (48.2%) and without (49.5%) had a medical home (adjusted prevalence ratio = 1.02, 95% confidence interval: 0.91–1.14). For children with heart conditions, preventive care was slightly more common among younger children and less common among those with family incomes 200–399% of the federal poverty level. Having a medical home was less common among younger children, non-Hispanic “other” race, and those with ≥2 other health conditions. Most children with heart conditions received preventive care, but less than half had a medical home, with disparities by age, socioeconomic status, race, and concurrent health conditions. These findings highlight opportunities to improve care for children with heart conditions.
Beyond Feminism? Jineolojî and the Kurdish Women's Freedom Movement
Authors: Al-Ali Nadje , Käser Isabel 
Published: November 2020

AbstractJineolojî, the women's science proposed and developed by the Kurdish Women's Freedom Movement, has become central to its transnational organizing both in the Middle East and in Europe and the Americas. Activists in the Kurdish women's movement critique positivist and androcentric forms of knowledge production as well as liberal feminism. They instead propose Jineolojî, which aims to rediscover women's histories and restore women's central place in society. Based on a series of interviews with Kurdish women involved in developing Jineolojî, this article first situates Jineolojî within wider transnational and decolonial feminist approaches and then draws out the main ideas constituting Jineolojî. We focus on the ways Jineolojî speaks to ongoing discussions within transnational feminist knowledge production. Our article critically assesses the claim of Kurdish women activists who present Jineolojî as a new science and paradigm that goes beyond feminism while developing our argument that Jineolojî represents an important continuation of critical interventions made by marginalized women activists and academics transnationally. Moreover, our article illustrates that Jineolojî provides a helpful ideological underpinning for and epistemology of Kurdish women's political struggle for gender-based equality and justice.
EphB2 mediates social isolation-induced memory forgetting
Authors: Wu Xin-Rong , Zhang Yu , Liu Xian-Dong , Han Wu-Bo , Xu Nan-Jie , Sun Suya 
Published: November 2020

AbstractSocial isolation in adolescence leads to lasting deficits, including emotional and cognitive dysregulation. It remains unclear, however, how social isolation affects certain processes of memory and what molecular mechanisms are involved. In this study, we found that social isolation during the post-weaning period resulted in forgetting of the long-term fear memory, which was attributable to the downregulation of synaptic function in the hippocampal CA1 region mediated by EphB2, a receptor tyrosine kinase which involves in the glutamate receptor multiprotein complex. Viral-mediated EphB2 knockdown in CA1 mimicked the memory defects in group-housed mice, whereas restoration of EphB2 by either viral overexpression or resocialization reversed the memory decline in isolated mice. Taken together, our finding indicates that social isolation gives rise to memory forgetting by disrupting EphB2-mediated synaptic plasticity, which may provide a potential target for preventing memory loss caused by social isolation or loneliness.
Lipidomics of the brain, retina, and biofluids: from the biological landscape to potential clinical application in schizophrenia
Authors: Zhuo Chuanjun , Hou Weihong , Tian Hongjun , Wang Lina , Li Ranli 
Published: November 2020

AbstractSchizophrenia is a serious neuropsychiatric disorder, yet a clear pathophysiology has not been identified. To date, neither the objective biomarkers for diagnosis nor specific medications for the treatment of schizophrenia are clinically satisfactory. It is well accepted that lipids are essential to maintain the normal structure and function of neurons in the brain and that abnormalities in neuronal lipids are associated with abnormal neurodevelopment in schizophrenia. However, lipids and lipid-like molecules have been largely unexplored in contrast to proteins and their genes in schizophrenia. Compared with the gene- and protein-centric approaches, lipidomics is a recently emerged and rapidly evolving research field with particular importance for the study of neuropsychiatric disorders such as schizophrenia, in which even subtle aberrant alterations in the lipid composition and concentration of the neurons may disrupt brain functioning. In this review, we aimed to highlight the lipidomics of the brain, retina, and biofluids in both human and animal studies, discuss aberrant lipid alterations in correlation with schizophrenia, and propose future directions from the biological landscape towards potential clinical applications in schizophrenia. Recent studies are in support of the concept that aberrations in some lipid species [e.g. phospholipids, polyunsaturated fatty acids (PUFAs)] lead to structural alterations and, in turn, impairments in the biological function of membrane-bound proteins, the disruption of cell signaling molecule accessibility, and the dysfunction of neurotransmitter systems. In addition, abnormal lipidome alterations in biofluids are linked to schizophrenia, and thus they hold promise in the discovery of biomarkers for the diagnosis of schizophrenia.
Somatic copy number gains in MYC, BCL2, and BCL6 identifies a subset of aggressive alternative-DH/TH DLBCL patients
Authors: Krull Jordan E. , Wenzl Kerstin , Hartert Keenan T. , Manske Michelle K. , Sarangi Vivekananda , Maurer Matthew J. , Larson Melissa C. , Nowakowski Grzegorz S. , Ansell Stephen M. , McPhail Ellen , Habermann Thomas M. , Link Brian K. , King Rebecca L. , Cerhan James R. , Novak Anne J. 
Published: November 2020

AbstractDouble/triple hit lymphoma (DH/TH), known as high-grade B-cell lymphoma (HGBL), is an aggressive diffuse large B cell lymphoma (DLBCL), defined as having concurrent MYC, BCL2, and/or BCL6 gene rearrangements. While gene rearrangements represent significant genetic events in cancer, copy number alterations (CNAs) also play an important role, and their contributions to rearrangements have yet to be fully elucidated. Using FISH and high-resolution CNA data, we defined the landscape of concurrent gene rearrangements and copy gains in MYC, BCL2, and BCL6, in a cohort of 479 newly diagnosed DLBCL. We also show that concurrent translocations and copy number alterations, in combinations similar to DH/TH, identify a unique subset of DLBCL, alternative DH/TH, that have survival outcomes similar to DH/TH DLBCL patients.
Digit ratio (2D:4D) and transgender identity: new original data and a meta-analysis
Authors: Siegmann Eva-Maria , Müller Tobias , Dziadeck Isabelle , Mühle Christiane , Lenz Bernd , Kornhuber Johannes 
Published: November 2020

AbstractPreviously reported associations between second-to-fourth digit length ratio (2D:4D), a proxy for prenatal androgen load, and transgender identity have been inconsistent. The objectives of the present study were to provide additional original data and an updated meta-analysis concerning this association. In a study of 464 participants, we compared the 2D:4D of transgender individuals with age- and sex-matched controls. Patients were recruited at a specialized psychiatrist’s medical office, whereas controls were hired via flyers, advertisements, and as convenience sample. A random-effects meta-analysis of the literature (17 samples, n = 3674) also quantifies the overall magnitude of the difference in 2D:4D between transgender individuals and controls. In our study providing new original data, we found a significantly higher (i.e. feminized) left-hand 2D:4D in the male-to-female transgender (MtF) identity [mean age: 32.3 (18; 61)] than in the male control group [mean age: 34.5 (18; 65)] with a Cohen’s d = 0.271. Concordantly, the meta-analytic results suggest a significant difference in 2D:4D among MtF individuals compared to male controls [g = 0.153; 95% CI (0.063; 0.243)], which was even more pronounced when individuals had been diagnosed by a clinician instead of self-identified as transgender [g = 0.193; 95% CI (0.086; 0.300)]. In both studies, no significant results were revealed for female-to-male transgender individuals [mean age: 26.1 (18; 53)] versus female controls [mean age: 27.2 (18; 55)]. This original investigation and the updated meta-analysis clarify the association between transgender identity and 2D:4D indicating the influence of prenatal androgen on the development of gender identity in subjects born as males.