bluuebunny/crossref_metadata_2025_split huggingface dataset:
A feasibility study with a novel, dynamic, and disposable over‐the‐counter device for the management of stress urinary incontinence
Authors: Naor Mika S. , Kaploun Alex , Friedman Boris 
Published: December 2020

AbstractAimsThis study aimed to evaluate the initial efficacy, safety, and usability of a novel, dynamic, and disposable intravaginal device in women suffering from stress urinary incontinence (SUI).MethodsTwenty‐six women with SUI were recruited to perform a modified 1‐h Pad Weight Gain (PWG) test. In this test, women drank 250–500 ml of water, were given a pre‐weighed pad, and asked to perform a set of incontinence‐inducing activities. At the end of the activities session, the pad was removed and weighed. This test was performed both with and without the Nolix device. Three efficacy endpoints measured were continuous percent reduction in urine leakage, dryness (defined as pad weight increase by no more than 1 g), and improvement in pad weight (measured as continuous percent reduction in PWG ≥ 50%). Any adverse events, reported by subjects during the device use were recorded. The usability and user's satisfaction were assessed using the Benefit, Satisfaction, and Willingness to Continue and Nolix Satisfaction questionnaires.ResultsThe average reduction in PWG was 79.4%. The average reduction in urine leakage while using the device was at least 70%. In addition, in 79.5% of tests, the clinically meaningful level of improvement in PWG was achieved. Use of the device produced substantial improvement in the patient's perceived quality of life. No adverse events were reported during the study.ConclusionThe Nolix device served as a noninvasive, effective, and well‐tolerated treatment option for reducing SUI in a modified 1‐h PWG test with a set of incontinence‐inducing activities.
Design and Preparation of a 3D Photonic Glass with a Broad Infrared Gap
Authors: Zhang Feng , Qiu Lili , Li Renbin , Qiao Yu , Meng Zihui 
Published: December 2020

AbstractPhotonic glasses with infrared gaps can be used as surface coating materials to effectively change the infrared radiation characteristics of substrate. In this research, a photonic glass with an infrared broad gap could be prepared easily in thermostatic water bath by a simple and fast baking protocol. The photonic glass prepared had a broad gap from 4.25 to 4.57 μm, centering at 4.45 μm, which was slightly different from the result of numerical simulation due to the existence of the internal disordered structure. The infrared transmission diagram showed that the infrared transmittance of a substrate covered by the photonic glass can be reduced from 80 % to 25 % at infrared atmosphere window of 3∼5 μm, which proved the ability of the material to regulate and control the infrared electromagnetic wave. In addition, the material can significantly restrain the infrared radiation of the substrate at 60 °C, which was expected to achieve stealth under the infrared detection.
New microsphere cobalt complex: preparation and catalytic consideration for the synthesis of some heterocyclic compounds
Authors: Ghorbani‐Choghamarani Arash , Bastan Hosna , Taherinia Zahra 
Published: December 2020

AbstractHerein a novel cobalt complex prepared by combination of Co(NO3)2.6H2O and thiosalycilic acid. Prepared microsphere cobalt complex was characterized by XRD, FTIR, TGA, BET, ICP and SEM techniques. Also, we report here an efficient method for the preparation of pyrroloacridine‐1(2H)‐one derivatives from a three‐component condensation reaction of amine, dimedone, and isatin and synthesis of chromeno [2, 3‐ d] pyrimidin‐8‐amines by reaction of benzaldehyde, α‐naphthol, malononitrile, and ammonium acetate in the presence of microsphere cobalt complex as the catalyst. The microsphere cobalt complex can be recovered without great loss of catalytic activity.
Membrane-embedded TSPO: an NMR view
Authors: Rivière Gwladys , Jaipuria Garima , Andreas Loren B. , Leonov Andrei , Giller Karin , Becker Stefan , Zweckstetter Markus 
Published: December 2020

AbstractTranslocator Protein (18 kDa) (TSPO) is a mitochondrial transmembrane protein commonly used as a biomarker for neuroinflammation and is also a potential therapeutic target in neurodegenerative diseases. Despite intensive research efforts, the function of TSPO is still largely enigmatic. Deciphering TSPO structure in the native lipid environment is essential to gain insight into its cellular activities and to design improved diagnostic and therapeutic ligands. Here, we discuss the influence of lipid composition on the structure of mammalian TSPO embedded into lipid bilayers on the basis of solid-state NMR experiments. We further highlight that cholesterol can influence both the tertiary and quaternary TSPO structure and also influence TSPO localization in mitochondria-associated endoplasmic reticulum membranes.
Survival After Adrenalectomy for Metastatic Hepatocellular Carcinoma: A 25‐year Institutional Experience
Authors: Staubitz JI. , Hoppe‐Lotichius M. , Baumgart J. , Mittler J. , Lang H. , Musholt TJ. 
Published: December 2020

AbstractBackgroundExtrahepatic manifestation of hepatocellular carcinoma (HCC) is rare and primarily affects lung, lymph nodes and bone. Metastases to the adrenal glands are relatively infrequent. This 25‐year institutional experience aimed for an analysis of factors influencing survival in patients undergoing surgery for HCC adrenal metastasis.MethodsA retrospective analysis of the institutional database of the Clinic for General‐, Visceral‐ and Transplantation Surgery of the University Medical Center Mainz, Germany, was performed. Patients who underwent surgery for HCC adrenal metastases from January 1995 to June 2020 were included. Pre‐, peri‐ and postoperative factors with potential influence on survival were assessed.ResultsIn 16 patients (14 males, two females), one bilateral and 15 unilateral adrenalectomies were performed (13 metachronous, three synchronous). Thirteen operations were carried out via laparotomy, and three adrenalectomies were minimally invasive (two laparoscopic, one retroperitoneoscopic). Median overall survival (after HCC diagnosis) was 35 months, range: 5–198. Median post‐resection survival (after adrenalectomy) was 15 months, range: 0–75. Overall survival was longer in patients with the primary HCC treatment being liver transplantation (median 66 months) or liver resection (median 51 months), compared to only palliative intended treatment of the primary with chemotherapy (median 35 months) or local ablation (median 23 months).ConclusionsSurgery is a feasible treatment option for patients with adrenal metastases originating from HCC. In patients who underwent adrenalectomy for HCC adrenal metastasis, overall survival was superior, if primary HCC treatment was potentially curative (liver transplantation or resection).
Outcome and EBRA migration analysis of a reconstruction cage in acetabular revision arthroplasty: a clinical and radiological study
Authors: Dammerer Dietmar , Blum Philipp , Putzer David , van Beeck Annelies , Nogler Michael , Thaler Martin 
Published: December 2020

Abstract
Purpose
Restoration cages and bone allografts have been proposed to manage severe acetabular bone defects. We aimed to investigate the migration behaviour of a restoration cup and impacted allograft bone in severe acetabular defects with Einzel-Bild-Röntgen-Analyse (EBRA).

Methods
Applying a retrospective study design, 64 cases treated between 2009 and 2016 were reviewed. We determined the preoperative Charlson Comorbidity Index (CCI), pre- to postoperative WOMAC score, blood loss and functional outcome. From preoperative x rays, the acetabular deficiencies were classified according to Paprosky. Cup migration analyses were performed with EBRA.

Results
Mean age at surgery was 73 (range: 38–93) years. According to the classification by Paprosky et al., 50% (n = 32) of our patients showed a type III B and 28.1% (n = 18) a type III A defect. Radiological follow-up for migration analysis was 35 (range: 4–95) months. Migration analysis showed a mean cup migration of 0.7 mm (range: 5.7–9.6) medial and 1.8 mm (range: 1.7–12.6) cranial.

Conclusion
In conclusion, acetabular restoration cages in combination with bone impaction grafting showed a low revision rate at a mean follow-up of 35 months. Mean cup migration revealed low rates after 2 years and suggested a stable postoperative implant position.
Consensus statement from the international consensus meeting on post-traumatic cranioplasty
Authors: Iaccarino C. , Kolias A. , Adelson P. D. , Rubiano A. M. , Viaroli E. , Buki A. , Cinalli G. , Fountas K. , Khan T. , Signoretti S. , Waran V. , Adeleye A. O. , Amorim R. , Bertuccio A. , Cama A. , Chesnut R. M. , De Bonis P. , Estraneo A. , Figaji A. , Florian S. I. , Formisano R. , Frassanito P. , Gatos C. , Germanò A. , Giussani C. , Hossain I. , Kasprzak P. , La Porta F. , Lindner D. , Maas A. I. R. , Paiva W. , Palma P. , Park K. B. , Peretta P. , Pompucci A. , Posti J. , Sengupta S. K. , Sinha A. , Sinha V. , Stefini R. , Talamonti G. , Tasiou A. , Zona G. , Zucchelli M. , Hutchinson P. J. , Servadei F. 
Published: December 2020

Abstract
Background
Due to the lack of high-quality evidence which has hindered the development of evidence-based guidelines, there is a need to provide general guidance on cranioplasty (CP) following traumatic brain injury (TBI), as well as identify areas of ongoing uncertainty via a consensus-based approach.

Methods
The international consensus meeting on post-traumatic CP was held during the International Conference on Recent Advances in Neurotraumatology (ICRAN), in Naples, Italy, in June 2018. This meeting was endorsed by the Neurotrauma Committee of the World Federation of Neurosurgical Societies (WFNS), the NIHR Global Health Research Group on Neurotrauma, and several other neurotrauma organizations. Discussions and voting were organized around 5 pre-specified themes: (1) indications and technique, (2) materials, (3) timing, (4) hydrocephalus, and (5) paediatric CP.

Results
The participants discussed published evidence on each topic and proposed consensus statements, which were subject to ratification using anonymous real-time voting. Statements required an agreement threshold of more than 70% for inclusion in the final recommendations.

Conclusions
This document is the first set of practical consensus-based clinical recommendations on post-traumatic CP, focusing on timing, materials, complications, and surgical procedures. Future research directions are also presented.
How Depressive Symptoms Hinder Positive Information Processing: An Experimental Study on the Interplay of Cognitive Immunisation and Negative Mood in the Context of Expectation Adjustment
Authors: Kube Tobias , Glombiewski Julia Anna 
Published: December 2020

AbstractBackgroundPeople with depression maintain negative expectations despite disconfirming positive experiences by reappraising or discarding novel positive information, referred to as “cognitive immunisation”. A second body of literature suggests that negative mood can negatively affect information processing. Bridging these two lines of research, the present study examined the interplay of cognitive immunisation and negative mood in the context of expectation modification.MethodsIn a student sample (N = 152), we used a well-established experimental paradigm to examine the adjustment of performance expectations in response to positive performance feedback, and its relation to depressive symptoms. In a 2 × 2 design, participants received either a negative mood induction, a cognitive immunisation manipulation, both, or no further manipulation.ResultsParticipants from all experimental groups revised their previous expectations significantly in line with positive performance feedback. However, depressive symptoms were a negative predictor of expectation adjustment, and a moderation analysis indicated that this effect was particularly pronounced if participants underwent the negative mood induction.ConclusionsConsistent with previous work, depressive symptoms were associated with a reduced ability to integrate positive information. Furthermore, our results suggest that the activation of negative mood in people with elevated levels of depression may hamper learning from new positive experience.
Derivative NMR spectroscopy for J-coupled multiplet resonances using short time signals (0.5 KB) encoded at low magnetic field strengths (1.5T). Part I: water suppressed
Authors: Belkić Dževad , Belkić Karen 
Published: December 2020

AbstractThe theme of this study is within the realm of basic nuclear magnetic resonance (NMR) spectroscopy. It relies upon the mathematics of signal processing for NMR in analytical chemistry and medical diagnostics. Our objective is to use the fast Padé transform (both derivative and nonderivative as well as parametric and nonparametric) to address the problem of multiplets from J-coupling appearing in total shape spectra as completely unresolved resonances. The challenge is exacerbated especially for short time signals (0.5 KB, no zero filling), encoded at a standard clinical scanner with the lowest magnetic field strengths (1.5T), as is the case in the present investigation. Water has partially been suppressed in the course of encoding. Nevertheless, the residual water content is still more than four times larger than the largest among the other resonances. This challenge is further sharpened by the following question: Can the J-coupled multiplets be resolved by an exclusive reliance upon shape estimation alone (nonparametric signal processing)? In this work, the mentioned parametric signal processing is employed only as a gold standard aimed at cross-validating the reconstructions from nonparametric estimations. A paradigm shift, the derivative NMR spectroscopy, is at play here through unprecedentedly parametrizing total shape spectra (i.e. solving the quantification problem) by sole shape estimators without fitting any envelope.
Politeness and reputation in cultural evolution
Authors: Mühlenbernd Roland , Wacewicz Sławomir , Żywiczyński Przemysław 
Published: December 2020

AbstractPoliteness in conversation is a fascinating aspect of human interaction that directly interfaces language use and human social behavior more generally. We show how game theory, as a higher-order theory of behavior, can provide the tools to understand and model polite behavior. The recently proposed responsibility exchange theory (Chaudhry and Loewenstein in Psychol Rev 126(3):313–344, 2019) describes how the polite communications of thanking and apologizing impact two different types of an agent’s social image: (perceived) warmth and (perceived) competence. Here, we extend this approach in several ways, most importantly by adding a cultural-evolutionary dynamics that makes it possible to investigate the evolutionary stability of politeness strategies. Our analysis shows that in a society of agents who value status-related traits (such as competence) over reciprocity-related traits (such as warmth), both the less and the more polite strategies are maintained in cycles of cultural-evolutionary change.
An Interpretation of Weights in Linear Opinion Pooling
Authors: Romeijn Jan-Willem 
Published: December 2020

AbstractThis paper explores the fact that linear opinion pooling can be represented as a Bayesian update on the opinions of others. It uses this fact to propose a new interpretation of the pooling weights. Relative to certain modelling assumptions the weights can be equated with the so-called truth-conduciveness known from the context of Condorcet's jury theorem. This suggests a novel way to elicit the weights.
Sustainability as an integrative principle: The role of international law in Arctic resource development
Authors: Shibata Akiho , Chuffart Romain 
Published: December 2020

Abstract
This article addresses the normative potential of the principle of sustainability to integrate the rules, principles, and procedures of international law applicable in the Arctic, so that Arctic international law can be posited more holistically and systematically. The holistic and integrative approach towards international law is particularly called for in the context of the Arctic, as the inextricable interconnectedness between its changing natural environments, its societal particularities, and its economic and industrial potential is the fundamental characteristic of the Arctic. In line with the purpose of the special issue, this article takes up a harder case of sustainability, in addressing Arctic mineral resource development. This article posits the principle of sustainability as a principle with an integrative function operating behind the primary norms relating to resource development at the international law level. In response to the claim of fragmented nature of the law at issue, this article calls for an academic examination into the normative function of the sustainability principle to forge the relevant and evolving norms applicable in the specific context of the Arctic mineral resource development towards an integral, coherent whole. This aim will be pursued using the analytical methodology employed by the International Law Commission’s (ILC) work on the “fragmentation of international law” (2006) and the “principle of integration” as identified by the International Law Association’s (ILA) work on the international law relating to sustainable development (2002–12). Finally, as an initial attempt to articulate the legal reasoning for such integration, this article examines the legal institution of environmental impact assessment (EIA) as a tool to present a holistic view of the international law on Arctic mineral resource development.
Selective amplification of the chirped attosecond pulses produced from relativistic electron mirrors
Authors: Tan Fang , Wang Shao Yi , Zhang Bo , Zhang Zhi Meng , Zhu Bin , Wu Yu Chi , Yu Ming Hai , Yang Yue , Li Gang , Zhang Tian Kui , Yan Yong Hong , Lu Feng , Fan Wei , Zhou Wei Ming , Gu Yu Qiu 
Published: December 2020

AbstractIn this paper, the generation of relativistic electron mirrors (REMs) and the reflection of an ultra-short laser off this mirrors are discussed, applying two-dimensional particle-in-cell (2D-PIC) simulations. REMs with ultra-high acceleration and expanding velocity can be produced from a solid nanofoil illuminated normally by an ultra-intense femtosecond laser pulse with a sharp rising edge. Chirped attosecond pulse can be produced through the reflection of a counter-propagating probe laser off the accelerating REM. In the electron moving frame, the plasma frequency of the REM keeps decreasing due to its rapidly expanding. The laser frequency, on the contrary, keeps increasing due to the acceleration of REM and the relativistic Doppler shift from the lab frame to the electron moving frame. Within an ultra-short time interval, the two frequencies will be equal in the electron moving frame, which leads the resonance between laser and REM. The reflected radiation near this interval and the corresponding spectra will be amplified due to the resonance. Through adjusting the arriving time of the probe laser, certain part of the reflected field could be selectively amplified or depressed, leading to the selectively adjusting of the corresponding spectra.
ON THE -RANK OF CLASS GROUPS OF DIRICHLET BIQUADRATIC FIELDS
Authors: Fouvry Étienne , Koymans Peter , Pagano Carlo 
Published: December 2020

AbstractWe show that for
$100\%$
of the odd, square free integers
$n> 0$
, the
$4$
-rank of
$\text {Cl}(\mathbb{Q} (i, \sqrt {n}))$
is equal to
$\omega _3(n) - 1$
, where
$\omega _3$
is the number of prime divisors of n that are
$3$
modulo
$4$
.
Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase
Authors: Sun Pengkai , Liu Yan , Ma Tengfei , Ding Jianping 
Published: December 2020

AbstractHuman NAD-dependent isocitrate dehydrogenase or HsIDH3 catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the TCA cycle. HsIDH3 exists and functions as a heterooctamer composed of the αβ and αγ heterodimers, and is regulated allosterically and/or competitively by numerous metabolites including CIT, ADP, ATP, and NADH. In this work, we report the crystal structure of HsIDH3 containing a β mutant in apo form. In the HsIDH3 structure, the αβ and αγ heterodimers form the α2βγ heterotetramer via their clasp domains, and two α2βγ heterotetramers form the (α2βγ)2 heterooctamer through insertion of the N-terminus of the γ subunit of one heterotetramer into the back cleft of the β subunit of the other heterotetramer. The functional roles of the key residues at the allosteric site, the pseudo allosteric site, the heterodimer and heterodimer–heterodimer interfaces, and the N-terminal of the γ subunit are validated by mutagenesis and kinetic studies. Our structural and biochemical data together demonstrate that the allosteric site plays an important role but the pseudo allosteric site plays no role in the allosteric activation of the enzyme; the activation signal from the allosteric site is transmitted to the active sites of both αβ and αγ heterodimers via the clasp domains; and the N-terminal of the γ subunit plays a critical role in the formation of the heterooctamer to ensure the optimal activity of the enzyme. These findings reveal the molecular mechanism of the assembly and allosteric regulation of HsIDH3.
Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes
Authors: Bueno Paula Carolina Pires , Abarca Luis Francisco Salomé , Anhesine Naira Buzzo , Giffoni Maíra Silva , Pereira Fabiola Manhas Verbi , Torres Roseli Buzaneli , de Rayran Walter RamosSousa , Ferreira Paulo Michel Pinheiro , Pessoa Claudia , Cavalheiro Alberto José 
Published: December 2020

AbstractCasearia sylvestris is an outstanding representative of the Casearia genus. This representability comes from its distinctive chemical profile and pharmacological properties. This species is widespread from North to South America, occurring in all Brazilian biomes. Based on their morphology, 2 varieties are recognized: C. sylvestris var. sylvestris and C. sylvestris var. lingua. Despite the existence of data about their chemical composition, a deeper understanding of the specialized metabolism correlation and variation in respect to environmental factors and its repercussion over their biological activities was still pending. In this study, an UHPLC-DAD-based metabolomics approach was employed for the investigation of the chemical variation of 12 C. sylvestris populations sampled across 4 Brazilian biomes and ecotones. The correlation between infraspecific chemical variability and the cytotoxic and antioxidant activities was achieved by multivariate data analysis. The analyses showed that C. sylvestris var. lingua prevailed at Cerrado areas, and it was correlated with lower cytotoxic activity and high level of glycosylated flavonoids. Among them, narcissin and isorhamnetin-3-O-α-L-rhamnopyranosyl-(1 → 2)-α-L-arabinopyranoside showed good correlation with the antioxidant activity. Conversely, C. sylvestris var. sylvestris prevailed at the Atlantic Forest areas, and it was associated with high cytotoxic activity and high content of clerodane diterpenoids. Different casearins showed good correlation (R2  = 0.3 – 0.70) with the cytotoxic activity. These findings highlighted the great complexity among different C. sylvestris populations, their chemical profile, and the related biological activities. Consequently, it can certainly influence the medicinal properties, as well as the quality and efficacy, of C. sylvestris phytomedicines.