bluuebunny/crossref_metadata_2025_split huggingface dataset:
FUNCTIONAL OUTCOME OF SIMULTANEOUS ACL RECONSTRUCTION AND HTO FOR MEDIAL COMPARTMENT OSTEOARTHRITIS
Authors: Shah Dhruv , Shah Ashit 
Published: December 2024

IntroductionInstability in ACL deficient knees can lead to medial compartment osteoarthritis. The risk of developing significant OA is 5x higher in knees with ACL deficiency. In associated Varus, there is quicker progression of the medial OA along with a varus thrust exerting strain on the ACL graft.The simultaneous valgus HTO and ACL reconstruction decompresses the medial tibiofemoral joint, corrects the mechanical-axis and reduces strain on the graft. Outcomes for this simultaneous procedure are still unclear in literature and we attempt evaluating its functional outcome.MethodsThis Panel study was performed using data from 2019 to 2022 on 21 patients who had ACL insufficiency with Varus or medial OA and underwent a simultaneous Opening-wedge HTO with Arthroscopic ACL reconstruction. The mean follow-up was 2 years. The patients were evaluated with IKDC and Lysholm scores, Lachman test and ROM pre and post-operatively. The HKA was compared pre and post-operatively and the complications were evaluated. The progression of OA was evaluated with serial radiographs post-operatively.ResultsThere was a significant improvement in lifestyle and knee joint function post-operatively. The mechanical femorotibial angle was corrected from an average of 8.2° Varus to 0.8° Valgus. There was a significant improvement in IKDC and Lysholm scoring (IKDC score improved to 86.20 from 34.48 and the Lysholm score improved to 89 points from 37 points). There was significant improvement in the laxity which was evaluated by Lachman test. One patient had a clinical progression of medial-OA. No patients had non-union, graft or implant failure.ConclusionSingle stage HTO and ACL Reconstruction in patients with medial OA or Varus with ACL insufficiency is an option showing a satisfactory functional and radiological outcome along with activity scores.
TIBIAL TRAY DEBONDING IN PS NEXGEN TOTAL KNEE ARTHROPLASTY IS LINKED TO POLYETHYLENE INSERT BACKSIDE DEFORMATION
Authors: Langton David , Bhalekar Rohan , Wells Stephen , Nargol Matthew , Natu Sonali , Nargol Antoni , Waller Susan , Pabbruwe Moreica , Sidaginamale Raghavendra 
Published: December 2024

ObjectivesWe identified an unusual pattern of backside deformation on polyethylene (PE) inserts of contemporary total knee replacements (TKRs). The PE backside's margins were inferiorly deformed in TKRs with NexGen central-locking trays. This backside deformation was significantly associated with tray debonding. Furthermore, recent studies have shown high rate of tray debonding in PS NexGen TKRs. Subsequently, a field safety notice was issued regarding the performance of this particular device combination and the Option tray has been withdrawn from use. Therefore, we hypothesised that the backside deformation of PS inserts may be greater than that of CR inserts.Design and MethodsAt our national implant retrieval centre, we used peer-reviewed techniques to analyse changes in the bearing wear rate and backside surface deformation of NexGen PE inserts using coordinate measuring machines [N=84 (CR-43 and PS-41) TKRs with non-augmented-trays]. Multiple regression was used to determine which variable had the greatest influence on backside deformation. The amount of cement cover on trays was quantified as a %of the total surface using Image-J software.ResultsThe median (IQR) bearing wear rate of the PS PEs [14(8-22) mm3/year] was not significantly different(p=0.154) to that of the CR PEs [18(8-27)mm3/year]. The median (IQR) backside deformation of the PS inserts [294(239-361) µm] was significantly greater (p<0.001) than that of the CR inserts [212(158-258)µm]. Multiple regression modelling showed that duration in-vivo (p=0.037), central-clearance between insert and tray (p<0.001) and constraint (p=0.003) were significantly associated with PE backside-deformation. 38(93%) PS and 31(72%) of CR trays exhibited ≤10% of cement cover. Non-contacting profilometry and microscopy revealed marked pitting and abrasive changes to the superior surface of the tray.ConclusionThis explant study showed the PE backside deformation was significantly higher in PS than in CR inserts and this may be one explanation for the unsatisfactory clinical performance reported with this device combination.
Different medications for seasonal allergic rhinitis in adults: A systematic review and meta-analysis
Authors: Qin Jiang-Yuan , Huang Geng , Pan Zhi-Hui , Liao Lan-Fang , Hu Heng-Fen 
Published: December 2024

BACKGROUND
While the efficacy of medications such as fluticasone furoate (FF), fluticasone propionate (FP), and azelastine-fluticasone (AF) has been substantiated in comparison to their respective placebo controls, uncertainties persist regarding the comparative effectiveness of different intranasal agents.
AIM
To evaluate the efficacy of FP, FF, and AF in the treatment of adult patients with seasonal allergic rhinitis (SAR) using a meta-analytic approach.
METHODS
A computer search was conducted in Cochrane Library, PubMed, and EMBASE databases to identify randomized controlled trials assessing the effectiveness and safety of FF, FP, and AF in treating SAR. Data on treatment safety and efficacy were extracted and analyzed through meta-analysis.
RESULTS
A total of 20 studies were included, comprising 10590 participants. The results of the direct meta-analysis indicated that, compared to placebo, both relative Total Nasal Symptom Score (rTNSS) and relative Total Ocular Symptom Score (rTOSS) significantly decreased post-intervention [mean difference (MD) = -1.48, 95% confidence interval (CI): -1.73 to -1.22; MD = -0.66, 95%CI: -0.82 to -0.49], with similar findings observed across the FF, FP, and AF subgroups. The network meta-analysis results showed that for improving rTNSS and rTOSS, the SUCRA values ranking from highest to lowest were AF, FP, FF, and placebo. Improvements in rTNSS and rTOSS with FP, FF, and AF were all significantly greater than those observed with placebo, with AF demonstrating superior efficacy compared to both FP and FF. No statistically significant difference in rTNSS improvement was found between FP and FF, although FP exhibited significantly greater improvement in rTOSS compared to FF.
CONCLUSION
In adult patients with SAR, the combination of azelastine and fluticasone shows a significant effect in improving nasal and ocular symptoms, with FP demonstrating marked improvement in ocular symptoms compared to FF.
Prognostic value of baseline alkaline phosphatase of 177Lu‐PSMA radioligand therapy in metastatic castration‐resistant prostate cancer: A systematic review and meta‐analysis
Authors: Zhang Tianhe , Li Wuxue , Wei Haiyang , Huang Zhiheng , Yang Junkai , Zeng Hanyi , Zhou Zhiyong , Zhao Xinghua 
Published: December 2024

Background
Current studies have shown inconsistent results regarding the impact of baseline alkaline phosphatase (ALP) levels on the prognosis of metastatic castration-resistant prostate cancer (mCRPC) patients who undergo 177Lu-prostate-specific membrane antigen (PSMA) radioligand therapy (PRLT). Therefore, a comprehensive meta-analysis is needed to clarify the implications.

Methods
This study was carried out in full compliance with the PRISMA protocol 2020, and a comprehensive search was conducted through PubMed, Web of Science, and Embase for published literature up to April 1st, 2024. Random-effects models were used to assess the correlation between baseline ALP and overall survival (OS) or progression-free survival (PFS) of mCRPC patients treated with 177Lu-PRLT, with a significance level set at α = 0.05.

Results
A total of 12 articles were included in this study. The pooled effect estimates for baseline ALP and OS were 1.134 (95% CI: 1.035–1.245), I2 = 78.7%, P < 0.05. Regarding baseline ALP and PFS, the pooled effect estimate was found to be 2.14 (95% CI: 1.232–3.718), I2 = 93.3%, P < 0.05. Subgroup analysis revealed minimal heterogeneity among articles using a cut-off value ≥220U/L when examining the association between baseline ALP and OS; whereas for baseline ALP and PFS, there was also minimal heterogeneity observed among articles that adjusted for confounders.

Conclusion
This meta-analysis demonstrates a significant association between elevated baseline ALP levels in mCRPC patients prior to 177Lu-PRLT treatment and inferior OS and PFS. Timely monitoring of baseline ALP levels can provide valuable insights for clinical decision-making and patient counseling.
Qualitative insights on emergency preparedness and response to marburg virus disease in Ghana: The role of risk communication and community engagement
Authors: Agboh Herman Nuake Kofi , Adjei-Okai Grace , Adjei George Adjeisah 
Published: December 2024

Objectives
Faith-based healthcare providers have played pivotal roles in recent public health responses to disease outbreaks, such as Ebola, COVID-19, and Marburg Virus Disease. However, the literature on their performance remains scarce. This research therefore evaluates the risk communication and community engagement capacity of the Christian Health Association of Ghana (CHAG) during the Marburg Disease Virus outbreak in Ghana.

Method
Data were obtained from 15 clinical and nonclinical health workers affiliated with CHAG and the Ghana Health Service (GHS). Online interviews were conducted to assess the coordination of risk communication and community engagement during Marburg Virus outbreak in Ghana. Thematic analysis was employed for data analysis.

Findings
Active engagement of national-level stakeholders, including the Ministry of Health and the Ghana Health Service, was observed. Outreach activities encompassing surveillance and contact tracing were also executed. However, resource constraints led to passive involvement of frontline workers in stakeholder meetings and risk communication activities, posing a limitation to the Risk Communication and Community Engagement (RCCE) effort.

Conclusion
To address health system vulnerabilities and misinformation in low-resourced countries during health emergencies, a bottom-up approach is vital. This approach will enhance the capacity of communities, professionals, NGOs, and media to counter infodemics and disinformation. Government and healthcare facility owners must ensure robust logistical and policy preparations to effectively equip healthcare facilities for future disease outbreaks.
Building the future: Toward a sustainable material transition in architecture and construction
Authors: Kropp Cordula , Aicher Simon 
Published: December 2024

In the introduction, we discuss the need for a material transition in architecture and construction and the challenges it poses. Drawing on innovation research, the multi-level perspective (MLP), and thousands of years of building history, we identify the potential for change, the obstacles that need to be overcome, and the importance of standards, in particular of established industry standards. The introduction also includes a brief description of each article.
Determination of Air Quality Protection and Management Strategic Area : Case Study of Tangerang City
Authors: Bontong Septepanus Gala , Permadi Didin Agustian , Benjamin Precious 
Published: December 2024

Metropolitan cities are often associated with anthropogenic activities that affect air quality. Tangerang, as a buffer city in the Greater Jakarta area, needs control strategies to tackle severe air pollution problem. Government Regulation No. 22/2021 requires the establishment of Air Quality Protection and Management Areas (AQPMA) in every city, including Tangerang. The determination of AQPMA involve emissions inventories, air quality, population density, land use, and meteorological conditions, using secondary data and air quality modeling with AERMOD. The results of the emission inventory show that the largest contribution comes from the manufacturing and road transportation industries, with NOx 19,747, CO 556,341, PM10 27,001, PM2.5 22,080, SO2 2,233, and NMVOC 295,482 (in Gigagrams/year). The result of the air model then accordance with measurements at AQMS Pasir Jaya in 2022. The average annual concentration results at this station are NOx 35, CO 1,200, PM10 38, PM2.5 39, and SO2 7.5 (in μg/m3). Ciledug is the sub-district with the highest population density, which is 19,233 people/km2. Based on AQPMA scores, eight very high-risk sub-districts must be a priority in mitigating clean air in Tangerang. A similar approach can be used in other cities to map vulnerability to air pollution as mandated by AQPMA.
Microstructural and Mechanical Characterization of Spray-Formed and Vacuum Cast AISI 440C-Mod Martensitic Stainless Steel
Authors: Rodríguez V. , Nadimpalli V. K. , Pedersen D. B. , Ruiz A. , Somers M. A. J. 
Published: December 2024

Abstract
The spray-forming process is a promising processing route for producing high-performance high-carbon steels. In this study, as-received and hardened/tempered spray-formed (SF) AISI 440C-Mod steel is compared to its vacuum cast (VaC) counterpart. For materials microstructure characterization scanning electron microscopy, X-ray diffraction analysis, energy dispersive spectroscopy, and electron backscatter diffraction were utilized. For the characterization of the mechanical properties and performance hardness, tensile, and compression testing were performed. The results show that the SF steel has a microstructure that is very different from the VaC condition. The differences in the microstructure of the steels after the different processing routes can be explained consistently by differences in the solidification rate and the rate of subsequent cooling of the solidified structure. In particular, the identity, morphology, and size of the primary carbides depend strongly on the combination of solidification and cooling rates. The differences in microstructures have a decisive influence on the mechanical properties of as-manufactured and hardened/tempered steels. The present findings demonstrate the potential of spray forming to produce high-performance AISI 440C-Mod martensitic stainless steel with improved mechanical properties compared to VaC steel.
Nickel-Free Austenitic Stainless Steel Manufactured by Laser Powder-Bed Fusion from Martensitic Powder Mixed with Interstitial Compounds
Authors: König C. , Valente E. H. , Nadimpalli V. K. , Tokman Y. G. , Christiansen T. L. , Somers M. A. J. 
Published: December 2024

Abstract
Using laser powder bed fusion (L-PBF), nickel-free austenitic stainless steel was manufactured from mixing AISI 420S martensitic stainless-steel powder with austenite-stabilizing components. Chromium nitride (Cr2N), chromium carbide (Cr3C2), chromium (Cr) and graphite (C) powder were admixed in different quantities. The resulting microstructures were investigated using light- and electron microscopy, X-ray diffraction, and hardness indentations. Nitrogen, carbon, and chromium from the admixed powders were dissolved in solid solution; no remnants of nitrides/carbides were identified. The as-built specimens had a lower nitrogen content than the mixed powders. Insufficient additions of austenite-stabilizing elements resulted in a dual-phase microstructure of austenite and martensite, which experienced in-situ tempering of martensite during fusion of consecutive layer(s) in the L-PBF process. Relatively high contents of austenite-stabilizing elements resulted in a fully austenitic microstructure with a hardness of 380–500 HV5, depending on Cr and interstitial content. The tendency for forming hot cracks was found to correlate with the solidification interval as calculated using a modified version of the Scheil-Gulliver model.
Tarantino’s Auteurist Anachronisms
Authors: Swanson Cole D. 
Published: December 2024

With a penchant for provocation, Quentin Tarantino has an unmistakably postmodern approach to soundtrack design. As an archetypal “melomane” auteur (Gorbman 2007), he frequently juxtaposes the iconic and the ironic, making use of late sixties pop-rock and the music of seventies genre films—spaghetti westerns, Blaxploitation, horror—in surprising and occasionally disturbing ways (Garner 2001, Tincknell 2006, Coulthard 2012). The latter half of his career has been explicitly oriented around historical revisionism, utilizing this music to imagine what “might have been” if life were more like cinema (Garner 2013). But, in his 2012 antebellum western Django Unchained, Tarantino makes use of two works from the Classical-Romantic canon that don’t fit neatly within his normal approach: the Dies irae from Verdi’s Requiem and Beethoven’s “Für Elise.” This music stands out as anachronistic, rupturing the historical and stylistic logic at work within the film, as well as Tarantino’s oeuvre more broadly.
This article explores the surprising inclusion of nineteenth-century music within Tarantino’s constructed film-world, bound as his texts typically are within his highly specific audiophilic and cinephilic taste. The tangible break from his signature style offers an opportunity to assess the limitations of auteurist control itself, to consider how and why an auteur may temporarily decenter their own musical preferences. I interpret this as a conscious strategy of audiovisual rupture, in which Tarantino intentionally destabilizes his constructed film-world as a method of historical critique.
The analysis focuses on a scene set to Verdi’s Dies irae, in which Tarantino restages the famous climax of The Birth of a Nation (D.W. Griffiths, 1915) set to Wagner’s “Ride of the Valkyries.” This sequence revives Griffith’s work and its racist ideology in order to parody it, temporarily surrendering control of the film’s historical imagination only to reclaim it and imagine other possibilities. This push-and-pull suffuses the narrative of Django Unchained as a whole, concerned as it is with the hero’s journey toward self-determination. I argue that Tarantino’s use of nineteenth-century music reveals tensions around control and liberation, speaking to his anxieties as a filmmaker and his philosophy around historical revisionism.
Simulator for Teaching Computed Tomography Principle
Authors: Voda Petr , Kordek David , Jezbera Daniel , Masopust Pavel , Bezrouk Ales 
Published: December 2024

Computed tomography (CT) is one of the most important imaging methods in clinical medical practice. Students of medicine have an opportunity to learn about its principles during the classes of the medical biophysics. For a high-quality understanding of the function of CT and to increase the curriculum attractiveness, it is advisable to include such clinical equipment or its simulator in the practical lessons. However, regarding operational safety and related maintenance, CT devices are very expensive and demanding. Therefore, the aim of this work was to create a cheap, operationally easy, and safe CT simulator. The device simulates the principle of CT by transmitting visible light through cubes with a built-in filter of defined attenuation simulating various human tissues. During hands-on training, students first measure radiation intensities without a sample (I0) and with single cubes (Ii). In the second task, students measure a matrix consisting of four different cubes, irradiating the matrix from different directions and simulating the CT principle. Based on the measurements, the students calculate the linear attenuation of each cube and the corresponding CT numbers and compare the results. The simulator's control is intuitive, provided measurement results are consistent and automatically fed into an interactive report that compares the measured data with the students' calculations, verifies the results, and finally stores them in the database. The main benefit of the study is to bring cheap and effective tools for the demonstration of the CT principle, which can operate each student during the practical lessons, followed by supporting teaching materials.
A Turkic script in the Carpathian Basin: The identity-marking functions of the Székely script
Authors: Sándor Klára 
Published: December 2024

AbstractThis paper discusses variations and changes in the identity-marking function of a writing of Turkic origin, the Székely script, from the thirteenth century to the present day. The script's peculiarity lies in the fact that during its known history, it had only an identity-marking function; no significant knowledge-communicating function can be found in any of its monuments.
Evaluation of cortical contour of suspicious axillary lymph nodes using ultrasound among various molecular subtypes of breast cancer
Authors: Gadde Pujitha , Dev Bhawna , Gnanavel Harini 
Published: December 2024

: In this study, we assessed specific morphological features of axillary lymph nodes, including the longitudinal axis to short axis ratio, distortion of the corticomedullary interface, cortical contour, nodal core sign, and perinodal hyperechogenic ring using a high-frequency linear probe. Among these features, the p-value was significant for cortical contour, warranting special emphasis. This focus on cortical contour may help reduce the need for immunohistochemistry in the future, proportionately lowering associated costs.: To evaluate B-mode ultrasound features of suspicious axillary lymph nodes in histopathologically proven cases of breast cancer and assess whether these features vary between different molecular subtypes of breast cancer. A total of 74 patients with histopathologically confirmed breast cancer, complete immunohistochemistry data, and proven metastatic axillary lymph nodes were evaluated. The sonomorphological characteristics of these metastatic axillary lymph nodes were subsequently correlated with the molecular subtype of breast cancer. Radiologists performed the ultrasound assessments, while pathologists confirmed histopathological diagnoses. Among all morphological features, only the cortical contour of the lymph node showed an association with the immunohistochemistry subtype of breast cancer, making our study unique in its ability to assess specific features of abnormal lymph nodes in relation to molecular subtypes of the disease.: Our study highlights a positive correlation between abnormal cortical contour and specific molecular subtypes of breast cancer. A concentric pattern predominates in the Luminal A subtype and HER2 neu-enriched subtype; an eccentric pattern is most common in the triple-negative basal-like subtype; and a focal pattern of cortical thickening is notably present in the Luminal B HER2+ subtype.