bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of NiAl double hydroxide@polypyrrole materials for high‐performance supercapacitors
Authors: Cao Xiao‐Ju , Zeng Hong‐Yan , Yi Mo‐Yu , Zou Kai‐Min , Xu Sheng 
Published: November 2019

AbstractA novel NiAl double hydroxide@polypyrrole (LDH@PPy) core–shell material was designed and fabricated by a facile in situ oxidative polymerization of pyrrole (Py) monomer. The microstructure and morphology of the LDH@PPy composites were determined by X‐ray diffractometer, Fourier transform infrared (FTIR), scanning electron microscopy/transmission electron microscopy, and thermogravimetric and differential thermal, revealing that the polypyrrole (PPy) was successfully coated onto the surface of the NiAl‐LDH (LDH) core and the loading amount of PPy impacted the thickness and the dispersion of the conductive PPy shell. The electrochemical performances of the LDH@PPy composites were also evaluated by cyclic voltammogram, electrochemical impedance spectroscopy, and galvanostatic charge–discharge measurements. The results indicated that the supercapacitor performances were attributed to the synergy of unique core–shell heterostructure and each individual component, where the LDH core provided the high‐energy storage capacity and the PPy shell with networks had high electronic conductivity. These shorted the ion diffusion pathway and made electrolyte ions more easily accessible for faradic reactions to enhance the electrochemical performance of the LDH@PPy composites. It was found that the LDH@PPy composite (LDH@PPy7) fabricated at 7 mL∙L−1 of Py monomer feed exhibiting the best electrochemical performances with high specific capacitance of 437.5 F∙g−1 at 2 A∙g−1 and excellent capacitance retention of about 91% after 1000 cycles. The work provides a simple approach for designing organic–inorganic core–shell materials with potential application in supercapacitors. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2019, 57, 1653–1662
Structure prediction of biological assemblies using GALAXY in CAPRI rounds 38‐45
Authors: Park Taeyong , Woo Hyeonuk , Baek Minkyung , Yang Jinsol , Seok Chaok 
Published: November 2019

AbstractWe participated in CARPI rounds 38‐45 both as a server predictor and a human predictor. These CAPRI rounds provided excellent opportunities for testing prediction methods for three classes of protein interactions, that is, protein‐protein, protein‐peptide, and protein‐oligosaccharide interactions. Both template‐based methods (GalaxyTBM for monomer protein, GalaxyHomomer for homo‐oligomer protein, GalaxyPepDock for protein‐peptide complex) and ab initio docking methods (GalaxyTongDock and GalaxyPPDock for protein oligomer, GalaxyPepDock‐ab‐initio for protein‐peptide complex, GalaxyDock2 and Galaxy7TM for protein‐oligosaccharide complex) have been tested. Template‐based methods depend heavily on the availability of proper templates and template‐target similarity, and template‐target difference is responsible for inaccuracy of template‐based models. Inaccurate template‐based models could be improved by our structure refinement and loop modeling methods based on physics‐based energy optimization (GalaxyRefineComplex and GalaxyLoop) for several CAPRI targets. Current ab initio docking methods require accurate protein structures as input. Small conformational changes from input structure could be accounted for by our docking methods, producing one of the best models for several CAPRI targets. However, predicting large conformational changes involving protein backbone is still challenging, and full exploration of physics‐based methods for such problems is still to come.
Conserved currents and T$$ \overline{\mathrm{T}} $$s irrelevant deformations of 2D integrable field theories
Authors: Conti Riccardo , Negro Stefano , Tateo Roberto 
Published: November 2019

Abstract
The T$$ \overline{\mathrm{T}} $$

T
¯

deformation of 2-dimensional QFTs is closely-related to Jackiw- Teitelboim gravity. It has been shown that, at the classical level, this perturbation induces an interaction between the stress-energy tensor and space-time and the equations of motion of the deformed theory map onto the original ones through a field-dependent coordinate transformation. At the quantum level, instead, the perturbation is induced by a modification of the original S-matrix by a specific CDD factor and, correspondingly, the quantised energy levels evolve according to a Burgers-type equation. In this paper, we point out that, in the framework of integrable field theories, there exist infinite families of perturbations characterised by a coupling between space-time and local conserved currents, labelled by the Lorentz spin. Similarly to the T$$ \overline{\mathrm{T}} $$

T
¯

case, the deformed models emerge through a field-dependent coordinate transformation involving conserved currents with higher Lorentz spin. Furthermore, using a geometric construction, we present a general method to derive the integrable hierarchy of the corresponding deformed models. The resulting expressions of the conserved currents turn out to be essential for the identification of the scattering phase factors which generate the deformations of the S-matrix, at the quantum level. Finally, the effect of the perturbations on the finite-volume spectrum is investigated using a non-linear integral equation. Exact spectral flow equations are derived, and links with previous literature, in particular on the J$$ \overline{\mathrm{T}} $$

T
¯

model, are discussed. While the classical setup is very general, the sine-Gordon model and its CFT limit are used as illustrative quantum examples. Most of the final equations and considerations are, however, of broader validity, or easily generalisable to more complicated systems.
Site-dependent induction of jasmonic acid-associated chemical defenses against western flower thrips in Chrysanthemum
Authors: Chen Gang , Kim Hye Kyong , Klinkhamer Peter GL , Escobar-Bravo Rocío 
Published: November 2019

AbstractMain conclusionLocal and systemic induction of JA-associated chemical defenses and resistance to western flower thrips in Chrysanthemum are spatially variable and dependent on the site of the JA application.AbstractPlants have evolved numerous inducible defense traits to resist or tolerate herbivory, which can be activated locally at the site of the damage, or systemically through the whole plant. Here we investigated how activation of local and systemic chemical responses upon exogenous application of the phytohormone jasmonic acid (JA) varies along the plant canopy in Chrysanthemum, and how these responses correlate with resistance to thrips. Our results showed that JA application reduced thrips damage per plant when applied to all the plant leaves or when locally applied to apical leaves, but not when only basal leaves were locally treated. Local application of JA to apical leaves resulted in a strong reduction in thrips damage in new leaves developed after the JA application. Yet, activation of a JA-associated defensive protein marker, polyphenol oxidase, was only locally induced. Untargeted metabolomic analysis further showed that JA increased the concentrations of sugars, phenylpropanoids, flavonoids and some amino acids in locally induced basal and apical leaves. However, local application of JA to basal leaves marginally affected the metabolomic profiles of systemic non-treated apical leaves, and vice versa. Our results suggest that JA-mediated activation of systemic chemical defense responses is spatially variable and depends on the site of the application of the hormone in Chrysanthemum.
Lymphatic vessels in human adipose tissue
Authors: Redondo Patricia de Albuquerque Garcia , Gubert Fernanda , Zaverucha-do-Valle Camila , Dutra Tatiana Pereira Pena , Ayres-Silva Jackline de Paula , Fernandes Natasha , de Souza Antonio Augusto Peixoto , Loizidou Marilena , Takiya Christina Maeda , Rossi Maria Isabel Doria , Borojevic Radovan 
Published: November 2019

AbstractDespite being considered present in most vascularised tissues, lymphatic vessels have not been properly shown in human adipose tissue (AT). Our goal in this study is to investigate an unanswered question in AT biology, regarding lymphatic network presence in tissue parenchyma. Using human subcutaneous (S-) and visceral (V-) AT samples with whole mount staining for lymphatic specific markers and three-dimensional imaging, we showed lymphatic capillaries and larger lymphatic vessels in the human VAT. Conversely, in the human SAT, microcirculatory lymphatic vascular structures were rarely detected and no initial lymphatics were found.
Climate change investment risk: optimal portfolio construction ahead of the transition to a lower-carbon economy
Authors: Benedetti Davide , Biffis Enrico , Chatzimichalakis Fotis , Fedele Luciano Lilloy , Simm Ian 
Published: November 2019

AbstractThere is an increasing likelihood that governments of major economies will act within the next decade to reduce greenhouse gas emissions, probably by intervening in the fossil fuel markets through taxation or cap & trade mechanisms (collectively “carbon pricing”). We develop a model to capture the potential impact of carbon pricing on fossil fuel stocks, and use it to inform Bayesian portfolio construction methodologies, which are then used to create what we call Smart Carbon Portfolios. We find that investors could reduce ex-post risk by lowering the weightings of some fossil fuel stocks with corresponding higher weightings in lower-risk fossil fuel stocks and/or in the stocks of companies active in energy efficiency markets. The financial costs of such de-risking strategy are found to be statistically negligible in risk-return space. Robustness of the results is explored with alternative approaches.
The effects of road crossings on stream macro-invertebrate diversity
Authors: Gál Blanka , Weiperth András , Farkas János , Schmera Dénes 
Published: November 2019

AbstractAlthough it is well known that the increasing size of the human population has a negative effect on freshwater biodiversity, the subject of whether or how the intersection of roads and streams (hereafter road crossings) influence the diversity of stream macro-invertebrates is under-researched. To fill this gap in our knowledge, we collected stream macro-invertebrates from road crossings (bridges and culverts) and compared their diversity with upstream and downstream sections. We found that road crossings had negative effects on the richness and abundance of native macro-invertebrates, as well as on the number of protected taxa. Our results showed also that alien individuals were more abundant at road crossings. These findings support the assumption that road crossings contribute to the spread of alien species. The assessment of environmental variables indicated that road crossings caused habitat modifications, and based on these it can be assumed that habitat modifications and associated phenomena (e.g. pollutants and storm events) were the major drivers of the observed patterns in biodiversity. Our results fill a knowledge gap and contribute to the deeper understanding of the effect of road crossings on freshwater biodiversity.
A Phase Ib/II, open-label, multicenter study of INC280 (capmatinib) alone and in combination with buparlisib (BKM120) in adult patients with recurrent glioblastoma
Authors: van den Bent Martin , Azaro Analia , De Vos Filip , Sepulveda Juan , Yung W. K. Alfred , Wen Patrick Y. , Lassman Andrew B. , Joerger Markus , Tabatabai Ghazaleh , Rodon Jordi , Tiedt Ralph , Zhao Sylvia , Kirsilae Tiina , Cheng Yi , Vicente Sergio , Balbin O. Alejandro , Zhang Hefei , Wick Wolfgang 
Published: November 2019

Abstract
Purpose
To estimate the maximum tolerated dose (MTD) and/or identify the recommended Phase II dose (RP2D) for combined INC280 and buparlisib in patients with recurrent glioblastoma with homozygous phosphatase and tensin homolog (PTEN) deletion, mutation or protein loss.

Methods
This multicenter, open-label, Phase Ib/II study included adult patients with glioblastoma with mesenchymal-epithelial transcription factor (c-Met) amplification. In Phase Ib, patients received INC280 as capsules or tablets in combination with buparlisib. In Phase II, patients received INC280 only. Response was assessed centrally using Response Assessment in Neuro-Oncology response criteria for high-grade gliomas. All adverse events (AEs) were recorded and graded.

Results
33 patients entered Phase Ib, 32 with altered PTEN. RP2D was not declared due to potential drug–drug interactions, which may have resulted in lack of efficacy; thus, Phase II, including 10 patients, was continued with INC280 monotherapy only. Best response was stable disease in 30% of patients. In the selected patient population, enrollment was halted due to limited activity with INC280 monotherapy. In Phase Ib, the most common treatment-related AEs were fatigue (36.4%), nausea (30.3%) and increased alanine aminotransferase (30.3%). MTD was identified at INC280 Tab 300 mg twice daily + buparlisib 80 mg once daily. In Phase II, the most common AEs were headache (40.0%), constipation (30.0%), fatigue (30.0%) and increased lipase (30.0%).

Conclusion
The combination of INC280/buparlisib resulted in no clear activity in patients with recurrent PTEN-deficient glioblastoma. More stringent molecular selection strategies might produce better outcomes.
Trial registration: NCT01870726.
DHA Attenuates Hypoxia/Reoxygenation Injury by Activating SSeCKS in Human Cerebrovascular Pericytes
Authors: Yu Yanli , Fang Haibin , Qiu Zhen , Xia Zhongyuan , Zhou Bin 
Published: November 2019

AbstractDocosahexaenoic acid (DHA) can alleviate cerebral ischemia/reperfusion injury by reducing blood–brain barrier permeability and maintaining its integrity, accompanied by an increased Ang-1/Ang-2 ratio; however, the underlying mechanisms of these effects remain unclear. Src-suppressed C kinase substrates (SSeCKS), a substrate of protein kinase C, plays an important role in maintaining cell junctions and cell morphology and regulating cell permeability. However, whether DHA can increase SSeCKS expression and then mediate the Ang-1/Ang-2 ratio still needs to be studied. Human cerebrovascular pericytes (HBVPs) cultured in vitro were divided into groups, treated with or without DHA along with SSeCKS siRNA to knockdown SSeCKS expression, and then subjected to 24 h of hypoxia followed by 6 h of reoxygenation. Cell viability; lactate dehydrogenase (LDH) release; and Ang-1, Ang-2 and VEGF activity were detected by using ELISA kits. The apoptosis rate was assessed by TUNEL flow cytometry. Expression of the SSeCKS, Ang-1, Ang-2 and VEGF proteins was evaluated by western blotting. Pretreatment with 10 μM or 40 μM DHA efficiently attenuated hypoxia/reoxygenation (H/R) injury by activating SSeCKS to increase the Ang-1/Ang-2 ratio and downregulate VEGF expression in HBVPs, as evidenced by decreased LDH release and apoptotic rates and increased HBVPs viability. Meanwhile, after we used SSeCKS siRNA to knock down SSeCKS protein expression, the protective effect of DHA on HBVPs following H/R injury was reversed. In conclusion, DHA can activate SSeCKS to increase the Ang-1/Ang-2 ratio and downregulate VEGF expression in HBVPs, thus reducing H/R injury.
Grounding at a distance
Authors: Baron Sam , Miller Kristie , Tallant Jonathan 
Published: November 2019

AbstractWhat distinguishes causation from grounding? One suggestion is that causation, but not grounding, occurs over time. Recently, however, counterexamples to this simple temporal criterion have been offered. In this paper, we situate the temporal criterion within a broader framework that focuses on two aspects: locational overlapping in space and time and the presence of intermediaries in space and time. We consider, and reject, the idea that the difference between grounding and causation is that grounding can occur without intermediaries. We go on to use the fact that grounding and causation both involve intermediaries to develop a better temporal criterion for distinguishing causation from grounding. The criterion is this: when a cause and effect are spatially disjoint, there is always a chain of causal intermediaries between the cause and the effect that are extended in time. By contrast, when the grounds and the grounded are spatially disjoint, there is always a chain of grounding intermediaries, but the chain need not be extended in time, it can be purely spatial. The difference between grounding and causation, then, is that causationrequirestime for chaining in a way that grounding does not.
Leaf Area Index evaluation in vineyards using 3D point clouds from UAV imagery
Authors: Comba L. , Biglia A. , Ricauda Aimonino D. , Tortia C. , Mania E. , Guidoni S. , Gay P. 
Published: November 2019

AbstractThe Leaf Area Index (LAI) is an ecophysiology key parameter characterising the canopy-atmosphere interface where most of the energy fluxes are exchanged. However, producing maps for managing the spatial and temporal variability of LAI in large croplands with traditional techniques is typically laborious and expensive. The objective of this paper is to evaluate the reliability of LAI estimation by processing dense 3D point clouds as a cost-effective alternative to traditional LAI assessments. This would allow for high resolution, extensive and fast mapping of the index, even in hilly and not easily accessible regions. In this setting, the 3D point clouds were generated from UAV-based multispectral imagery and processed by using an innovative methodology presented here. The LAI was estimated by a multivariate linear regression model using crop canopy descriptors derived from the 3D point cloud, which account for canopy thickness, height and leaf density distribution along the wall. For the validation of the estimated LAI, an experiment was conducted in a vineyard in Piedmont: the leaf area of 704 vines was manually measured by the inclined point quadrant approach and six UAV flights were contextually performed to acquire the aerial images. The vineyard LAI estimated by the proposed methodology showed to be correlated with the ones obtained by the traditional manual method. Indeed, the obtained R2 value of 0.82 can be considered fully adequate, compatible to the accuracy of the reference LAI manual measurement.
Cell culture propagation of foot-and-mouth disease virus: adaptive amino acid substitutions in structural proteins and their functional implications
Authors: Dill Veronika , Eschbaumer Michael 
Published: November 2019

AbstractFoot-and-mouth disease is endemic in livestock in large parts of Africa and Asia, where it is an important driver of food insecurity and a major obstacle to agricultural development and the international trade in animal products. Virtually all commercially available vaccines are inactivated whole-virus vaccines produced in cell culture, but the adaptation of a field isolate of the virus to growth in culture is laborious and time-consuming. This is of particular concern for the development of vaccines to newly emerging virus lineages, where long lead times from virus isolate to vaccine can delay the implementation of effective control programs. High antigen yields in production cells are also necessary to make vaccines affordable for less developed countries in endemic areas. Therefore, a rational approach to cell culture adaptation that combines prior knowledge of common adaptive mutations and reverse genetics techniques is urgently required. This review provides an overview of amino acid exchanges in the viral capsid proteins in the context of adaptation to cell culture.
Understanding Public Views on a Dam Construction Boom: the Role of Values
Authors: Schulz Christopher , Martin-Ortega Julia , Glenk Klaus 
Published: November 2019

AbstractLarge numbers of dams for hydroelectric power production are currently planned or under construction in many areas around the world. While positive and negative social and environmental impacts of dams are increasingly well understood, little is known about attitudes of the general public towards dams, even though benefits to wider society are often cited to legitimise their construction. In Brazil’s Upper Paraguay River Basin, more than 100 mostly small-scale hydropower dams are planned or under construction in what can be considered a regional dam construction boom. Here we analyse public preferences for strategies to manage dam impacts in the area by investigating the value base that underpins such preferences, drawing on the recently proposed Value Landscapes Approach as our theoretical framework and data from a large representative household survey (N = 1067). We find that contrasting attitudes towards dams, expressed in preferences for economically or ecologically oriented water policies are informed by opposing underlying value landscapes, that is, groups of closely related fundamental, governance-related, and assigned (water) values. While such tensions between opposing values can never be fully eliminated, our research nevertheless gives insights to policy-makers seeking to minimise value conflict and to improve the political legitimacy of public decision-making on dam construction. Moreover, we find that a majority of members of the general public would prefer concentrating dam construction on some rivers while keeping others free-flowing, with direct implications for ecosystems and inland fisheries. This finding may guide policy-makers wishing to develop publicly supported water resources management strategies.