bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Zinc Finger Antiviral Protein restricts SARS-CoV-2
Authors: Nchioua Rayhane , Kmiec Dorota , Müller Janis , Conzelmann Carina , Groß Rüdiger , Swanson Chad , Neil Stuart , Stenger Steffen , Sauter Daniel , Münch Jan , Sparrer Konstantin M. J. , Kirchhoff Frank 
Published: June 2020

SUMMARYRecent evidence shows that the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is highly sensitive to interferons (IFNs). However, the underlying antiviral effectors remain to be defined. Here, we show that Zinc finger antiviral protein (ZAP) that specifically targets CpG dinucleotides in viral RNA sequences restricts SARS-CoV-2. We demonstrate that ZAP and its cofactors KHNYN and TRIM25 are expressed in human lung cells. Type I, II and III IFNs all strongly inhibited SARS-CoV-2 and further induced ZAP expression. Strikingly, SARS-CoV-2 and its closest relatives from bats show the strongest CpG suppression among all known human and bat coronaviruses, respectively. Nevertheless, knock-down of ZAP significantly increased SARS-CoV-2 production in lung cells, particularly upon treatment with IFN-α or IFN-γ. Thus, our results identify ZAP as an effector of the IFN response against SARS-CoV-2, although this pandemic pathogen may be preadapted to the low CpG environment in humans.HighlightsSARS-CoV-2 and its closest bat relatives show strong CpG suppressionIFN-β, -γ and -λ inhibit SARS-CoV-2 with high efficiencyZAP restricts SARS-CoV-2 and contributes to the antiviral effect of IFNs
Acquisition of ionic copper by a bacterial outer membrane protein
Authors: Bhamidimarri Satya Prathyusha , Young Tessa R. , Shanmugam Muralidharan , Soderholm Sandra , Baslé Arnaud , Bumann Dirk , van den Berg Bert 
Published: June 2020

AbstractCopper, while toxic in excess, is an essential micronutrient in all kingdoms of life due to its essential role in the structure and function of many proteins. Proteins mediating ionic copper import have been characterised in detail for eukaryotes, but much less so for prokaryotes. In particular, it is still unclear whether and how Gram-negative bacteria acquire ionic copper. Here we show thatPseudomonas aeruginosaOprC is an outer membrane, TonB-dependent transporter that is conserved in many Proteobacteria and which mediates acquisition of both reduced and oxidised ionic copper via an unprecedented CxxxM-HxM metal binding site. Crystal structures of wild type and mutant OprC variants with silver and copper suggest that acquisition of Cu(I) occurs via a surface-exposed “methionine track” leading towards the principal metal binding site. Together with whole-cell copper quantitation and quantitative proteomics in a murine lung infection model, our data identify OprC as an abundant component of bacterial copper biology that may enable copper acquisition under a wide range of conditions.SignificanceCopper is an essential metal in biology due to its role in the structure and function of many proteins. Despite this, it is not very clear how bacteria acquire copper, especially for Gram-negative organisms. In this study we show that the outer membrane protein OprC has an unusual metal binding site that allows OprC to bind both reduced and oxidised ionic copper near-irreversibly. Given the versatility of OprC, its presence in many Proteobacteria and its abundance during lung infection in mice, our study shows that OprC is an important component of prokaryote copper biology that warrants further study to uncover its regulation and to assess its role in bacterial virulence.
Distinct genomic profiles are associated with treatment response and survival in ovarian cancer
Authors: de Witte Chris J. , Kutzera Joachim , van Hoeck Arne , Nguyen Luan , Boere Ingrid A. , Jalving Mathilde , Ottevanger Petronella B. , van Schaik - van de Mheen Christa , Stevense Marion , Kloosterman Wigard P. , Zweemer Ronald P. , Cuppen Edwin , Witteveen Petronella O. 
Published: June 2020

AbstractThe majority of patients with ovarian cancer ultimately develop recurrent chemotherapy resistant disease. Treatment stratification is mainly based on histological subtype and stage, prior response to platinum-based chemotherapy and time to recurrent disease. Here, we integrated clinical treatment, treatment response and survival data with whole genome sequencing profiles of 132 solid tumor biopsies of metastatic epithelial ovarian cancer to explore genome-informed stratification opportunities. Samples from primary and recurrent disease harbored comparable numbers of single nucleotide variants and structural variants. Mutational signatures represented platinum exposure, homologous recombination deficiency and aging. Unsupervised hierarchical clustering based on genomic input data identified specific ovarian cancer subgroups, characterized by homologous recombination deficiency, genome stability and duplications. The clusters exhibited distinct response rates and survival probabilities which according to our analysis could potentially be improved by genome-informed treatment stratification.
Epidemiology of malaria in an area with pyrethroid-resistant vectors in south-western Burkina Faso: a pre-intervention study
Authors: Somé Anthony , Zongo Issaka , Tchiekoi Bertin N’cho , Soma Dieudonné D. , Zogo Barnabas , Ouattara Mamadou , Somé Anyirékun F. , Dahounto Amal , Koffi Alphonsine A. , Pennetier Cédric , Moiroux Nicolas , Kouanda Seni , Dabiré Roch K. 
Published: June 2020

AbstractBackgroundThe objective of this study was to update malaria epidemiological profile prior to the implementation of a randomized controlled trial aiming to evaluate the efficacy of new vector control tools in complementary to the use of long-lasting insecticidal nets in Burkina Faso.MethodsWe carried out active and passive cross-sectional surveys to estimate the prevalence and incidence of malaria infection from August 2016 to July 2017 in 27 villages of the Diebougou health district.ResultsWith the passive survey, we extracted data from 4814 patients included in the study from August 2016 to July 2017. Malaria incidence showed a seasonal distribution, with an overall incidence rate estimated at 414.3 per 1000 person-years. In the active cross sectional surveys, we enrolled 2839, 2594 and 2337 participants respectively in September 2016, December 2016 and June 2017. Prevalence of malaria infection were respectively 41.5%, 43.5% and 32.3% in September 2016, in December 2016 and June 2017. Multivariate analysis showed that girls seemed to have a lower risk of malaria infection (OR = 0.86; 95% CI = 0.79 - 0.95; p = 0.004). The risk of malaria infection was significantly lower in third survey (June 2017) at the beginning of the rainy season (OR = 0.69; 95% CI = 0.6 - 0.8; p < 0.001) compared to the first survey (September 2016) which was performed during the rainy season. Children aged 6 to 59 months had a higher risk of malaria infection compared to those aged 10 to 17 years (OR = 0.58; 95% CI = 0.51 - 0.66).ConclusionMalaria burden remains high in this region of Burkina Faso despite substantial efforts made in malaria control during this current decade. Children under 5 years old were subject of malaria burden in this setting. This results reinforce the urgent need to develop alternative control strategies to complement those already existing.
An Agent Based Model for assessing spread and health systems burden for COVID-19 using a synthetic population in Rangareddy district, Telangana state, India
Authors: Narassima M S , Jammy Guru Rajesh , Pant Rashmi , Choudhury Lincoln , Aadharsh R , Yeldandi Vijay , Anbuudayasankar S P , Rangasami R , John Denny 
Published: June 2020

AbstractCOVID-19 disease, caused by SARS-CoV-2 virus, has infected over four million people globally. It has been declared as a “Public Health Emergency of International Concern” (PHE 1C), by the World Health Organization (1). Several mathematical models, mostly based on compartmental modeling, are being used for projections for COVID-19 in India. These projections are being used for policy level decisions and public health prevention activities (2,3). Unlike compartmental models, which consider population averages, Agent Based Models (ABM) consider individual behavior in the models for disease projections. ABMs, provide better insights into projections compared to compartmental models (4).We present an ABM approach with a synthetic population from Rangareddy district, Telangana state, India, to examine the patterns and trends of the COVID-19 in terms of infected, admitted, critical cases requiring intensive care and/ or ventilator support, mortality and recovery. The model is developed based on data pertaining to a local area, i.e. district, as this prove to be much helpful for policymaking compared to models estimating nation-wide disease projections. The parameters for the ABM model were defined and model run for a period of 365 days for three different non-pharmaceutical intervention (NPI) scenarios, namely; no lockdown, 50% lockdown and 75% lockdown scenarios. AnyLogic platform was used for the ABM simulations. Results revealed that the peak values and slope of the curve declined as NPI became more stringent. The results could provide a platform for researchers and modelers to explore using ABM approach for COVID-19 projections with inclusion of interventions and health system preparedness.
Artificial intelligence and mobile apps for mental healthcare: a social informatics perspective
Authors: Gamble Alyson 
Published: June 2020

PurposeFor decades, artificial intelligence (AI) has been utilized within the field of mental healthcare. This paper aims to examine AI chatbots, specifically as offered through mobile applications for mental healthcare (MHapps), with attention to the social implications of these technologies. For example, AI chatbots in MHapps are programmed with therapeutic techniques to assist people with anxiety and depression, but the promise of this technology is tempered by concerns about the apps' efficacy, privacy, safety and security.Design/methodology/approachUtilizing a social informatics perspective, a literature review covering MHapps, with a focus on AI chatbots was conducted from the period of January–April 2019. A borrowed theory approach pairing information science and social work was applied to analyze the literature.FindingsRising needs for mental healthcare, combined with expanding technological developments, indicate continued growth of MHapps and chatbots. While an AI chatbot may provide a person with a place to access tools and a forum to discuss issues, as well as a way to track moods and increase mental health literacy, AI is not a replacement for a therapist or other mental health clinician. Ultimately, if AI chatbots and other MHapps are to have a positive impact, they must be regulated, and society must avoid techno-fundamentalism in relation to AI for mental health.Originality/valueThis study adds to a small but growing body of information science research into the role of AI in the support of mental health.
Critical lifting simulation of heavy industrial construction in gaming environment
Authors: Sydora Christoph , Lei Zhen , Siu Ming Fung Francis , Han SangHyeok , Hermann Ulrich 
Published: June 2020

Purpose
Heavy industrial construction often relies on large mobile cranes to erect equipment and pre-assembled modules. Engineering calculations are required for the lifting analysis where lifting capacity is analyzed to ensure the feasibility of the lifting scenarios. Such engineering calculations are often presented in static formats, e.g. two-dimensional or three-dimensional models. However, it is difficult to help practitioners (e.g. lifting engineers, site crews and operators) understand the complexity of the lifting process and thus operational decisions are often made intuitively. Therefore, this paper aims to introduce a game-based simulation system to allow for interactive analysis of the lifting process to improve lifting efficiency and safety.

Design/methodology/approach
The proposed method treats the mobile crane as a robot with degree-of-freedoms, and the movements are simulated in the Unity game environment. The lifting capacity is calculated dynamically based on the lifting object weight, rigging weight and lifting radius.

Findings
Compared with the four-dimensional visualization, this development has added a dimension of real-time interactive simulation; this allows the users to understand the complexity and feasibility of the lifting process.

Originality/value
The developed prototype has been tested and validated using a real case study from a heavy industrial project with the possibility of generalizing crane lifting configurations.
Communication: the key for an effective interagency collaboration within the bushfire investigation network
Authors: De Sisto Marco , Handmer John 
Published: June 2020

PurposeThe purpose of this study is to identify strengths and weaknesses in knowledge sharing between related post-bushfire investigative agencies. Based on this study, such a sharing of knowledge is essential to enhance collaboration amongst practitioners in the reduction and management of the risk of bushfires.Design/methodology/approachThe authors use a case study methodology; the research design is based on comparative analysis of six post-bushfire investigative departments in Italy and Australia (Victoria). A total of 44 bushfire investigators were interviewed between 2012 and 2013, across the two countries. Using focus groups and face-to-face interviews, the extent and quality of intra- and interagency knowledge sharing is analysed.FindingsDespite the desire to collaborate, there are three main conditions that prevent an effective interagency collaboration within the bushfire investigation network, namely, separation, unidirectionality and interpersonal disengagement. This study finds that knowledge sharing suffers from a missing “feedback system” culture, where agencies give each other feedback with strictly bureaucratic purposes, rather than create an ongoing learning mechanism that develops after every investigation. At agency level, we also find that, sharing investigative knowledge and experience through daily and planned meetings is a standard practice to police members; but this is not found in the fire agencies. When made cross-country comparisons between Australia and Italy, the existence of common courses, joint manuals and the sharing of human resources witnessed in Australia (Victoria) is something that would benefit Italian agencies still trapped in a competitive and jurisdictional mindset. At the same time, Australian agencies might want to reconsider the separation between bushfire suppression and investigation, a distinction that has been made clear in Italy through the creation of full-time bushfire investigator positions.Practical implicationsThis paper contributes to the improvement of interagency collaboration through the development of an investigative “social knowledge”. It reinforces the assumption that, to reduce and effectively manage the risk of bushfires, a combined effort from different stakeholders involved in forensic investigation is necessary.Originality/valueGiven the lack of research undertaken in the area of bushfire investigation, the current paper represents a unique piece of work. It is unusual, not only in identifying the current issues within the bushfire investigation network but also in providing agencies with theoretical and practical insights on how to reduce the extremely high number of bushfires and their risks.
The effect of innovation-driven policy on innovation efficiency: based on the listed sports firms on Chinese new Third Board
Authors: Chen Gang , Breedlove John 
Published: June 2020

PurposeThis paper aims to examine the effect of innovation-driven polices on innovation efficiency of sport firms listed on the new Third Board in China.Design/methodology/approachFirm innovation efficiency, including comprehensive innovation efficiency, pure technical efficiency and scale innovation efficiency were calculated by using data envelopment analysis (DEA) models. The input variables and output variable in the DEA model were selected through correlation analysis. The effects of several innovation-driven policies on the innovation efficiency of sport firms were analyzed by a series of multiple regression analyses.FindingsRegarding the innovation efficiency evaluation of sport firms, total research and development (R&D) investment and total R&D staff are two suitable input variables, and total profit, sales revenue and new effective patent are three suitable output variables. Income tax relief for high-tech enterprise has a positive effect on comprehensive innovation efficiency and pure technical efficiency, and governmental subsidies have a negative effect on comprehensive innovation efficiency and pure technical efficiency. However, pretax deduction of R&D expenses does not have a significant effect on comprehensive innovation efficiency, pure technical efficiency and scale innovation efficiency, and income tax relief for high-tech enterprise and pretax deduction of R&D expenses also have no effect on scale innovation efficiency. For a large-scale sport firm, the negative effect of “governmental subsidies” and the positive effect of “income tax relief for high-tech enterprise” on its pure technical efficiency are more significant. For a sport firm with more R&D staff, governmental subsides and “income tax relief for high-tech enterprise” have more positive effect on its innovation efficiency.Practical implicationsThe study findings could potentially provide practical guidance to both managers and government-industry policymakers in the sports industry.Originality/valueFirstly, this paper focused on Chinese sport firms from a rising industry in a developing country (China). The related conclusions are conducive to the governmental management of new industries and the innovation management of new enterprises. Second, this paper analyzed the effect of three special innovation-driven policies on three types of innovation efficiency and explored enterprise innovation development in more detail. Third, this paper not only discusses the effect of innovation-driven policies on innovation efficiency, but also the heterogeneity of their effects.
Transglobal leadership approach to sustainable tourism competitiveness at tourism sector-engaged MSMEs through integrated human resource performance and responsible marketing
Authors: Hermawati Adya 
Published: June 2020

PurposeThis study aims to examine the effect of transglobal leadership on quality of work life (QWL), job involvement, organizational citizenship behavior (OCB) and human resource (HR) performance of tourism sector-engaged micro, small and medium enterprises (MSMEs) in East Java; to examine the moderating role of QWL, job involvement and OCB in the effect of transglobal leadership on HR performance of tourism sector-engaged MSMEs in East Java; to examine the effect of HR performance of tourism sector-engaged MSMEs on responsible tourism marketing and sustainable tourism competitiveness in East Java; and to examine the mediating role of responsible tourism marketing in the effect of HR performance of tourism sector-engaged MSMEs on sustainable tourism competitiveness in East Java.Design/methodology/approachThe population of this research was all HR executives of tourism sector-engaged MSMEs in East Java and domestic and foreign tourists in East Java. The sampling of the tourism sector-engaged MSMEs in East Java (in 16 tourism potential cities) was performed using a purposive sampling technique. Determination of the sample size was made using the minimum criterion from structural model, ranging from 100 to 200. Thus, it was determined that the number of tourism sector-engaged MSMEs studied in this research was 200 enterprises from 16 tourism potential cities in East Java. From each tourism sector MSME, four employees and three tourists were selected. In total, this research involved 800 employees and 600 tourists (both domestic and foreign).FindingsThis research found that transglobal leadership (X) , QBL (M1), job involvement (M2) and OCB (M3) had an effect on HR performance (Y). The results of this research highlighted that QWL variable (M1) moderated the effect of transglobal leadership (X) on HR performance (Y). It was found that job involvement variable (M2) moderated the effect of transglobal leadership (X) on HR performance (Y). This research also detected that OCB variable (M3) moderated the effect of transglobal leadership (X) on HR performance (Y). This research found that HR performance (Y) had an effect on responsible marketing (Z1). It was obtained in this research that HR performance (Y) also had an effect on sustainable tourism competitiveness (Z2). Finally, this research found that responsible marketing (Z1) had an effect on sustainable tourism competitiveness (Z2).Originality/valueRegarding the originality of this research, the holistic compilation was integrated from the theoretical concept of the HR and marketing strategies through the implementation of the tourism marketing concept and application that are responsible for tourism sector-engaged MSMEs in East Java. Of course, tourists need to get a good understanding of the marketing strategy to participate in controlling the sustainable tourism competitiveness in East Java.
The supply and design of different types of venues for business events
Authors: Nolan Emma 
Published: June 2020

Purpose
Hosting business events is no longer the preserve of hotels and purpose-built conference and exhibition centres. Today, visitor attractions, theatres, museums, universities and sporting complexes also compete for their share of the lucrative business events sector. However, few of these venues were originally designed and built to accommodate events but are now multipurpose in function and marketed to the events industry to secure a secondary source of income. This paper aims to evaluate the supply and design of venues for business events from both a historical and contemporary viewpoint.

Design/methodology/approach
As business events have specific venue requirements, ranging from extensive, accessible space for exhibitions to numerous rooms for plenary and syndicate conference sessions, choosing an appropriate venue from those available has become a considerable task. A review of key moments in history demonstrates how different types of venues have emerged and developed.

Findings
This study reveals how venues that have a similar background typically share features such as architectural design and layout. The paper discusses the characteristics of unusual, academic and sporting venues as well as hotels and purpose-built space to include factors such as availability, cost and location.

Originality/value
This paper provides an insight into the benefits and drawbacks of using different types of venues for business events and the advantages and challenges that these present to organisers. Case studies are embedded within this paper, illustrating the range of venues that are used to successfully host business events today. As there is limited literature that explores venue development for events, or commonalities of venue characteristics by type, the synthesis of these two important elements of event management makes this study an original and valuable contribution to the developing literature.