bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computer-navigated versus conventional total knee arthroplasty
Authors: Yu Yefeng , Sheng Jianming , Zhou Xiao 
Published: August 2020

AbstractBackground:The literature lacks studies that confirm whether the improved radiographic alignment that can be achieved with computer-navigated total knee arthroplasty (TKA) improves patients’ activities of daily living or the durability of total knee prostheses. Thus, in this protocol, we designed a randomized controlled trial to compare implant alignment, functional scores, and survival of the implant using computer-assisted surgery versus a conventional surgical technique.Methods:This prospective, blinded randomized controlled trial was conducted at our single hospital. This study was approved by the ethics committee of Jiaxing Second Hospital. The patient inclusion criteria were age 20 to 80 years’ old, a body mass index of ≤35 kg/m2, and consented for primary knee arthroplasty performed through a medial parapatellar approach by the senior author. We randomized consented study participants on a 1:1 ratio to 1 of 2 study groups using a computer-generated list of random numbers in varying block sizes. The primary outcome in this study was the Knee Injury and Osteoarthritis Outcome Score. Secondary outcomes were the Knee Society Score, Western Ontario and McMaster Universities Osteoarthritis Index, complications, and range of motion together with alignment and rotational positioning of the implant. Statistical significance was defined as aPvalue of ≤0.05.Conclusions:Authors hypothesized that computer-assisted surgery in primary TKA improves implant alignment, functional scores, and survival of the implant compared to the conventional technique.
Bloodletting at EX-HN6 as an adjunctive therapy to eye drops for stye
Authors: Qiao Hong-wei , Liu Na-wen , Wang Jin , Huang Shan , Yu Lei , Chen Zhong 
Published: August 2020

Abstract

Background:
This study evaluated the effectiveness and safety of bloodletting (BL) at ear-apex (EX-HN6) as an adjunctive therapy to eye drops for stye.

Methods:
This study systematically searched electronic databases from inception to March 1, 2020 in PUBMED, EMBASE, Cochrane Library, China National Knowledge Infrastructure, Chinese Scientific Journals Full-text Database, and WanFang Database. All potential randomized controlled trials (RCTs) investigating the effectiveness and safety of BL at EX-HN6 as an adjunctive therapy to eye drops for stye were included in this study. Study quality of all included studies was assessed by Cochrane Risk of Bias Assessment Tool. RevMan 5.3 software was used for statistical analysis and meta-analysis performance.

Results:
A total of 11 RCTs, involving 1718 subjects, were included in this study. Results showed that BL at EX-HN6 as an adjunctive therapy to eye drops was superior to the eye drops alone in enhancing total effectiveness rate (risk ratio [RR] 1.21, 95% confidence intervals [CIs] [1.11, 1.32], I
2 = 79%), and total cure rate (RR 1.28, 95% CIs [1.14, 1.43], I
2 = 69%). After removing two studies, results of subgroup analysis still showed significant improvements in total effectiveness rate (RR 1.13, 95% CIs [1.08, 1.18], I
2 = 0%), and total cure rate (RR 1.16, 95% CIs [1.08, 1.24], I
2 = 0%). No data of adverse reactions was reported in primary trials, thus, this study did not analyze adverse reactions of BL at EX-HN6 as an adjunctive therapy to eye drops for stye.

Conclusion:
BL at EX-HN6 as an adjunctive therapy to eye drops may benefit stye. However, high-quality RCTs addressing on this issue is still needed to warrant the findings of this study.
Challenges of BCLC stage C hepatocellular carcinoma
Authors: Que Jenny , Lin Chia-Hui , Lin Li-Ching , Ho Chung-Han 
Published: August 2020

Abstract
In this study, we evaluated the feasibility and efficacy of stereotactic body radiation therapy (SBRT) in the treatment of Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma (HCC).
This retrospective study evaluated 139 patients with BCLC stage C HCC who underwent CyberKnife SBRT between January 2009 and September 2017. All patients had BCLC-C, Child–Turcotte–Pugh score A-B. In-field control, overall survival (OS), progression free survival (PFS), and prognostic factors were evaluated.
An objective response rate was achieved in 81.5% patients (complete response, 36.2%, partial response, 45.3%). The median survival was 15.44 months, and the 1-, 3-, 5-year OS rates were 56%, 28%, and 20%, respectively. The median PFS was 6 months, the PFS rate at 1-, 3-, and 5-year were 35%, 14%, and 10%, respectively. In-field control of 1 to 2 years was achieved in 85.1% of patients. The major pattern of failure was out-field intrahepatic failure which comprised 42.9% of patients. Multivariate analysis revealed that the Child–Turcotte–Pugh score, macrovascular invasion, advance stage (III-IV), and tumor response rate were independent predictors of OS.
The result of our study shows that SBRT is a safe and effective therapeutic option for BCLC stage C HCC lesions that are unsuitable for standard loco-regional therapies, Moreover, SBRT has acceptable local control rates and low-treatment toxicity.
Hypoglycemic agents for non-alcoholic fatty liver disease with type 2 diabetes mellitus
Authors: Liu Su-Tong , Su Kai-Qi , Zhang Li-Hui , Liu Ming-Hao , Zhao Wen-Xia 
Published: August 2020

Abstract

Background:
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries, and strongly associated with type 2 diabetes mellitus (T2DM). Several studies have shown that hypoglycemic agents are effective for NAFLD combined with T2DM. However, there is still controversy over which hypoglycemic agent is the best for NAFLD combined with T2DM patients.

Objective:
To systematically evaluate the efficacy and safety of hypoglycemic agents in NAFLD combined with T2DM patients.

Methods:
A comprehensive electronic search will be conducted by searching Web of Science, PubMed, EMBASE, Cochrane Central Register of Controlled Trials, Clinical Trials and Chinese Biomedical Medicine. All randomized controlled trials of hypoglycemic agents interventions for NAFLD combined with T2DM will be identified. Two reviewers independently screened and evaluated each included study and extracted the outcome indexes. ADDIS 1.16.8 software will be used for the network meta-analysis and STATA 14 software will be used for drawing network evidence plots and funnel plots.

Conclusion:
This network meta-analysis will provide stronger evidence for the efficacy and safety of hypoglycemic agents in the treatment of NAFLD combined with T2DM, and provide a reference for clinical application.

Protocol registration number:
INPLASY202070016.
Effectiveness comparisons of different Chinese herbal injection therapies for acute cerebral infarction
Authors: Li Runmin , Li Ying , Li Bingchen , Sun Haiyang , Liu Xinyu , Ge Xin , Liu Yuanxiang , Yang Jiguo 
Published: August 2020

Abstract

Background:
Acute cerebral infarction (ACI) has a high incidence, recurrence rate, and mortality. Chinese herbal injections (CHIs) are widely used in the substitution therapy of ACI. Due to the lack of randomized trials comparing the efficacy of various injections directly, it is still difficult to judge the relative efficacy. Therefore, we intend to conduct a network meta-analysis to evaluate the benefit among these CHIs.

Methods:
According to the retrieval strategies, randomized controlled trials (RCTs) on CHI therapies for ACI will be obtained from China National Knowledge Infrastructure, WanFang, Chinese Scientific Journals Database, PubMed, Embase and Cochrane Library, regardless of publication date or language. Studies were screened based on inclusion and exclusion criteria, and the Cochrane risk bias assessment tool will be used to evaluate the quality of the literature. The network meta-analysis will be performed in Markov Chain Monte Carlo method and carried out with Stata 14 and WinBUGS 1.4.3 software. Ultimately, the evidentiary grade for the results will be evaluated.

Results:
This study will compare the efficacy and safety of CHIs in the treatment of ACI, and give a more reasonable choice.

Conclusion:
Our findings will provide references for future clinical decision and guidance developing.
INPLASY registration number: INPLASY202060087.
Contrecoup injury of the prefronto-thalamic tract in a patient with mild traumatic brain injury
Authors: Jang Sung Ho , Kwon Young Hyeon , Lee Sung Jun 
Published: August 2020

Abstract

Rationale:
We report on a patient with mild traumatic brain injury (TBI) with contrecoup injury of the prefronto-thalamic tract (PTT), as demonstrated by diffusion tensor tractography (DTT).

Patient concerns:
A 62-year-old female patient suffered a head trauma after falling backward. While working at a height of 85cm above the floor, she fell backward and struck the occipital area of her head on the ground. The patient experienced cognitive dysfunction and depressive mood after the head trauma.

Diagnoses:
The patient was diagnosed as mild TBI due to falling backward.

Interventions:
Clinical evaluation of her brain was performed at 2 months after onset.

Outcomes:
DTT at 2 months after onset revealed narrowings in the right ventrolateral and both orbitofrontal PTTs, whereas both the dorsolateral and left ventrolateral PTTs were not reconstructed.

Lessons:
Injuries of the PTTs associated with a contrecoup brain injury were demonstrated in a patient with mild TBI.
Acupuncture for the treatment of dry eye
Authors: Zhu Yongzheng , Zhao Qinyu , Jia Hongling , Zhang Hongxing , Zhang Yongchen 
Published: August 2020

Abstract

Background:
As a common ophthalmic disease, dry eye (DE) may bring several adverse effects on the quality of life for patients. In recent years, Acupuncture (AC) is becoming increasingly popular for treating DE. Thus, we conceived this systematic review aims to evaluate the effectiveness and safety of AC for DE objectively.

Methods:
The search results are restricted to randomized controlled trials and human studies. We will establish the inclusion criteria through discussion and design a detailed literature search strategy for each database. Articles are searched from 4 English databases (the Cochrane Library, PubMed, Web of Science, and EMBASE) and 4 Chinese databases (Wangfang, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, and Chinese scientific and technical journals database). The relevant studies published from the date of database inception until January 2020 will be collected. We will also search (International Clinical Trials Registry Platform), PROSPERO, and potential gray literature. Two reviewers independently perform literature screening, information extraction, and assessment of study quality. The outcome measures include primary outcome measures (Schirmer I test and break-up time), secondary outcome measures (Ocular Surface Disease Index, corneal fluorescein staining, and tear osmolarity), and safety outcome measures. Assessment of bias risk and data processing are performed using RevMan 5.3 software ( the Nordic Cochrane Centre, Copenhagen, Denmark).

Results:
We will evaluate the curative effect of AC for DE comprehensively based on multiple outcome measures.

Conclusion:
This systematic review will provide evidence for the effectiveness and safety of AC in the treatment of DE.

PROSPERO number:
CRD42019144790
His bundle pacing – a curative method
Authors: Pestrea Catalin , Gherghina Alexandra , Ortan Florin , Cismaru Gabriel , Radu Rosu 
Published: August 2020

Abstract

Introduction:
Pacing of the His bundle and conduction system seems an attractive site for pacing. Lead placement in His-pacing might be technically challenging due to surrounding structures and particular anatomic location.

Patient concerns:
A 62-years old male patient was admitted for recurrent syncope. Electrocardiographic monitoring revealed periods of complete atrioventricular block with left branch block morphology and a QRS duration of 160 ms.

Diagnosis:
A diagnosis of intermittent complete atrioventricular block was made with a Class I indication of permanent dual-chamber cardiac pacing.

Interventions:
A lead delivery system with a C315 His catheter and a Select Secure 3830 69 cm pacing lead was placed at the septal area of the atrioventricular junction with good pacing and sensing thresholds. An important narowing of the QRS was observed.

Outcomes:
After the procedure, good pacing and sensing parameters were observed.
Echocardiography revealed disappearance of the previously recorded ventricular dyssynchronism.
Device follow-up at 1 month and 3 months showed stable pacing and sensing parameters.

Conclusion:
Pacing the distal His bundle normalized the QRS complex, therefore “curing” both the atrioventricular and the left bundle branch conduction abnormalities. As such, the technique can be used as an alternative to cardiac electrical resynchronization therapy with acceptable pacing and detection thresholds and better ventricular activation pattern.
Intestinal tuberculosis in a patient with end-stage renal disease on hemodialysis
Authors: Lee In Hee , Kim Seong Gyu , Kwon Joong Goo , Yang Chun-Seok , Kang Sungmin , Kim Min-Kyung , Ahn Dong Jik 
Published: August 2020

Abstract

Rationale:
Intestinal tuberculosis (TB) is rarely seen in patients with end-stage renal disease (ESRD). We report an intestinal TB case with a clinical presentation similar to that of colon cancer in a patient with ESRD on hemodialysis.

Patient concerns:
A 49-year-old man presented with a 3-month history of general weakness and anorexia. He had been treated for stage 5 chronic kidney disease (CKD) due to diabetic nephropathy for the last 3 years. His blood urea nitrogen and serum creatinine levels were 96.9 and 8.1 mg/dL, respectively, at the time of admission; azotemia was accompanied by severe anemia, hypoalbuminemia, hyperkalemia, and metabolic acidosis. Hemodialysis was initiated for suspected exacerbation of uremia; however, intermittent fever, night sweats, and abdominal discomfort persisted.

Diagnoses:
Abdominal computed tomography (CT) and whole-body 18F-fluorodeoxyglucose positron emission tomography were indicative of ascending colon cancer with lymph node metastases. However, colonoscopy with biopsy revealed the formation of submucosal caseating granuloma and acid-fast bacillus.

Interventions:
We initiated quadruple therapy with isoniazid, rifampicin, pyrazinamide, and ethambutol. The patient continued the quadruple regimen for the first 2 months before switching to dual therapy and received anti-TB medications for a total of 12 months.

Outcomes:
After 9 months of standard anti-TB chemotherapy, polypoid residual lesions were noted during follow-up colonoscopy. Laparoscopy-assisted ileocecal resection was performed. No findings suggestive of recurrence of colonic TB were observed on follow-up abdominal CT at 6 months after discontinuation of anti-TB medications.

Lessons:
If non-specific uremic symptoms persist in patients with advanced CKD, the possibility of extrapulmonary TB such as intestinal TB must be considered. Also, in patients with radiologic suspicion of colon cancer, endoscopy with biopsy should be performed promptly to exclude colonic TB with similar clinical manifestations.
Screening of significant biomarkers with poor prognosis in hepatocellular carcinoma via bioinformatics analysis
Authors: Sun Quanquan , Liu Peng , Long Bin , Zhu Yuan , Liu Tongxin 
Published: August 2020

Abstract
Hepatocellular carcinoma (HCC) is a malignant tumor with unsatisfactory prognosis. The abnormal genes expression is significantly associated with initiation and poor prognosis of HCC. The aim of the present study was to identify molecular biomarkers related to the initiation and development of HCC via bioinformatics analysis, so as to provide a certain molecular mechanism for individualized treatment of hepatocellular carcinoma.
Three datasets (GSE101685, GSE112790, and GSE121248) from the GEO database were used for the bioinformatics analysis. Differentially expressed genes (DEGs) of HCC and normal liver samples were obtained using GEO2R online tools. Gene ontology term and Kyoto Encyclopedia of Gene and Genome (KEGG) pathway analysis were conducted via the Database for Annotation, Visualization, and Integrated Discovery online bioinformatics tool. The protein–protein interaction (PPI) network was constructed by the Search Tool for the Retrieval of Interacting Genes database and hub genes were visualized by Cytoscape. Survival analysis and RNA sequencing expression were conducted by UALCAN and Gene Expression Profiling Interactive Analysis.
A total of 115 shared DEGs were identified, including 30 upregulated genes and 85 downregulated genes in HCC samples. P53 signaling pathway and cell cycle were the major enriched pathways for the upregulated DEGs whereas metabolism-related pathways were the major enriched pathways for the downregulated DEGs. The PPI network was established with 105 nodes and 249 edges and 3 significant modules were identified via molecular complex detection. Additionally, 17 candidate genes from these 3 modules were significantly correlated with HCC patient survival and 15 of 17 genes exhibited high expression level in HCC samples. Moreover, 4 hub genes (CCNB1, CDK1, RRM2, BUB1B) were identified for further reanalysis of KEGG pathway, and enriched in 2 pathways, the P53 signaling pathway and cell cycle pathway.
Overexpression of CCNB1, CDK1, RRM2, and BUB1B in HCC samples was correlated with poor survival in HCC patients, which could be potential therapeutic targets for HCC.
Fracture treatment in the setting of cutaneous aspergillosis: a case report
Authors: Zhang Ting , Christopher Michael , Simske Natasha M. , Saddler Christopher M. , Keenan Thomas , Whiting Paul S. 
Published: August 2020

Abstract
The authors present the case of a patient who developed an Aspergillosis flavus (A flavus) superficial cutaneous infection which was identified at the time of cast removal, 2 weeks after immobilization of a closed distal third humerus fracture. Clinical and microbiological findings, as well as the treatment of this patient, are reported. An otherwise healthy 27-year-old male presented to the orthopaedic surgery clinic 2 weeks after a closed distal humerus fracture, which was initially immobilized with a functional removable brace. Upon cast removal, the patient was noted to have significant brown hyperkeratotic patches and plaques, studded with pustules in an annular configuration on his left posterior and lateral arm. Fungal culture later grew A flavus. The patient was started on both oral and topical antifungals and operative management of the displaced fracture was delayed until skin lesions resolved. Once clinical examination and negative repeat bedside potassium hydroxide were confirmed, open reduction and internal fixation was performed. The fracture healed uneventfully, and the patient did not develop any signs or symptoms of postoperative infection.
Outcomes of civilian pediatric craniocerebral gunshot wounds: A systematic review
Authors: Duda Taylor , Sharma Arjun , Ellenbogen Yosef , Martyniuk Amanda , Kasper Ekkehard , Engels Paul T. , Sharma Sunjay 
Published: August 2020

BACKGROUND
Pediatric craniocerebral gunshot injuries (CGIs) occur both in the context of accidental and intentional trauma. The incidence and physiology of pediatric CGIs merit reexamination of prognostic factors and treatment priorities. This study characterizes the current understanding of mortality and prognostic factors in this patient population.

METHODS
A systematic search was conducted. Selection criteria included all studies published since 2000, which described civilian isolated CGIs in pediatric patients. Data were analyzed qualitatively and quantitatively to identify factors prognostic for the primary outcome of mortality. Secondary outcomes included functional outcome status, requirement for surgery, and injury complications. Study quality was assessed with the Newcastle-Ottawa Scale. This study was registered with PROSPERO (CRD42019134231).

RESULTS
Initial search revealed 349 unique studies. Forty underwent full text screening, and eight studies were included in the final synthesis. The overall mortality rate was 44.8%. Most CGIs occurred in older teenagers. Aggressive surgical treatment was recommended by one author, while remaining studies emphasized clinical judgment. Reported prognostic factors include initial Glasgow Coma Scale, pupil reactivity, involvement of multiple lobes or deep nuclei, and bihemispheric injuries. Reported complications from CGIs included seizure, meningitis, abscess, cerebrospinal fluid leak, bullet migration, focal neurological deficits, endocrine abnormalities, cognitive deficits, and neuropsychological deficits. The Glasgow Outcome Scale was the predominant measure of function and demonstrated a moderate recovery in 17.4% and a good recovery in 27.3% of patients.

CONCLUSION
This systematic review analyzed the existing evidence for prognostic factors in the context of pediatric CGIs. Significant long-term clinical improvement is possible with interventions including urgent surgical therapy. Fixed bilateral pupils and low initial Glasgow Coma Scale correlate with mortality but do not predict all patient outcomes. Patients younger than 15 years are underreported and may have differences in outcome. The literature on pediatric CGIs is limited and requires further characterization.

LEVEL OF EVIDENCE
Systematic Review, level IV.
On the consistency of a class of
R
-symmetry gauged 6
D
N = (1,0) supergravities
Authors: Pang Yi , Sezgin Ergin 
Published: August 2020

R
-symmetry gauged 6
D
(1, 0) supergravities free from all local anomalies, with gauge groups
G
×
G

R

where
G

R

is the R-symmetry group and
G
is semisimple with rank greater than one, and which have no hypermultiplet singlets, are extremely rare. There are three such models known in which the gauge symmetry group is
G
1
×
G
2
×
U
(1)

R

, where the first two factors are

(

E
6

/

Z

3

)
×

E
7

,
G
2
×
E
7
and
F
4
×
Sp
(9). These are models with single tensor multiplet, and hyperfermions in the (1, 912), (14, 56) and (52, 18) dimensional representations of
G
1
×
G
2
, respectively. So far, it is not known if these models follow from string theory. We highlight key properties of these theories, and examine constraints which arise from the consistency of the quantization of anomaly coefficients formulated in their strongest form by Monnier and Moore. Assuming that the gauged models accommodate dyonic string excitations, we find that these constraints are satisfied only by the model with the
F
4
×
Sp
(9) ×
U
(1)

R

symmetry. We also discuss aspects of dyonic strings and potential caveats they may pose in applying the stated consistency conditions to the
R
-symmetry gauged models.