bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful management of immunotherapy-resistant respiratory failure in anti-mitochondrial M2 antibody-positive myositis by modified lung volume recruitment therapy: A case report
Authors: Takahashi Seiya , Inoue Hiroyasu , Amano Shizuki , Shinohara Takahiro , Mori Sara , Onizawa Kaho , Nabeshima Yoko , Komuro Hiroyasu , Yasumoto Taro , Mitsuhashi Rihito , Watanabe Daishi , Komaba Kazuki , Futamura Akinori , Nogawa Satoshi , Kinno Ryuta 
Published: December 2024

Rationale:
Anti-mitochondrial antibodies (AMA) M2-positive myositis can lead to severe respiratory failure. Traditional immunotherapies sometimes fail to address respiratory failure. Herein, this CARE-compliant case report described a patient with AMA-M2-positive myositis who recovered from ventilation with tracheostomy owing to immunotherapy-resistant respiratory failure to spontaneous breathing after modified lung volume recruitment (mLVR) therapy.

Patient concerns:
A 60-year-old man experienced general fatigue and shortness of breath. The patient had a notable degree of proximal muscle weakness. Blood test results revealed hyperCKemia. The serum AMA-M2 antibody was positive. A muscle magnetic resonance imaging revealed diffuse abnormal hyperintensities in both lower limb muscles. Needle electromyography demonstrated fibrillation and positive sharp waves at rest with early recruitment, suggesting myogenic changes. Progressive muscle weakness and clinical findings fulfilled the criteria for definite idiopathic inflammatory myopathy. We diagnosed him with AMA-M2-positive myositis. Notably, his thoracic mobility was decreased, resulting in CO2 narcosis, requiring ventilation. Two courses of intravenous methylprednisolone for 3 days followed by oral prednisolone for myopathy. However, his respiratory function remained compromised, resulting in a tracheostomy.

Diagnoses:
We diagnosed him with severe immunotherapy-resistant respiratory failure due to AMA-positive myositis that required ventilation and tracheostomy.

Interventions:
To address respiratory failure, this patient underwent the mLVR therapy using the LIC TRAINER (LT). The pressure was adjusted by the operator using a bag-valve mask (BVM), starting at 1500 mL and increasing it up to a maximum of 2500 mL, while avoiding excessive airway pressure.

Outcomes:
Respiratory function was evaluated by objective measures using chest wall mobility, inspiratory capacity (IC), vital capacity (VC), tidal volume (TV), and subjective measures using the visual analogue scale (VAS). Both objective and subjective scales showed significant improvements. The patient was weaned off ventilation 48 days after the initiation of mLVR therapy.

Lessons:
The mLVR therapy is an effective respiratory rehabilitation for patients with weakened respiratory muscles or tracheostomy. It allows the intensity of treatment to be adjusted based on the patient’s symptoms, making it both highly effective and safe. This case suggests that mLVR therapy may be effective in treating severe, immunotherapy-resistant respiratory failure in AMA-positive myositis.
Primary intracranial neuroendocrine tumor at the sphenoid ridge with metastasis to the spinal cord: A case report
Authors: Pan Siyuan , Chen Shuide , Richard Seidu A. , Lan Zhigang 
Published: December 2024

Rationale:
Neuroendocrine tumors (NETs) originate from neuroendocrine cells and they are depicted with both nerve cells as well as hormone-producing cells. These tumors were initially discovered in extracranial locations and central nervous system involvement is often a result of metastasis. Herein, we present a very rare case of primary intracranial neuroendocrine tumor (PINET) that masqueraded as meningioma at the sphenoid ridge with metastasis to the spinal cord in a patient without a known history of extracranial NET at the time of diagnosis.

Patient concerns:
A 52-year-old male presented with a 2-month history of headache and decreased vision in the left eye accompanied by inarticulation in speech for 1 month.

Diagnoses:
Magnetic resonance imaging of the head showed a space-occupying lesion in the left sphenoid ridge which was mistaken for meningioma.

Interventions:
The lesion was surgically resected and immunohistochemical evaluation revealed PINET. Postoperative positron emission tomography scan and magnetic resonance imaging of the thoracolumbar spine detected a tumor nodule in the thoracolumbar region which was a metastatic tumor. The metastatic lesion at the thoracolumbar spine was surgically resected and spinal fixation was carried out to stabilize the spine. Immunohistochemical evaluation of the spinal lesion also confirmed NET. He was further treated with several cycles of adjuvant chemotherapy and radiotherapy.

Outcomes:
Two years’ follow-up revealed no recurrence of the tumor and he is currently well. However, we are still following the patient because of the nature of the tumor.

Lesson:
PINET may be capable of metastasizing to spinal cord.
National Academies of Science, Engineering and Medicine Recommendations for Transformative Change in Women’s Health Research at the National Institutes of Health
Authors: Barcelona Veronica 
Published: December 2024

Abstract

Background
Due to significant gaps in knowledge around women’s health, Congress commissioned the National Academies of Science, Engineering and Medicine (NASEM) to conduct a consensus study on funding allocation, workforce needs, and priority research areas for the National Institutes of Health (NIH).

Objectives
This manuscript summarizes the key points of the new NASEM report on women’s health research for NIH, presents the relevance and importance for nursing research, and briefly discusses the need for increased representation of nurse scientists on NASEM panels.

Methods
Beginning in the Fall of 2023, a multidisciplinary panel of 17 experts was convened by NASEM to address gaps in women’s health research at NIH. The committee was tasked to identify research priorities for NIH-funded research with a focus on conditions that are female specific, more common in women, or affect women differently. In addition, the committee was asked to make recommendations on NIH training and education to strengthen the women’s health research workforce, changes to NIH structural, systems, and review processes, and allocation of funding to more equitably reflect the burden of disease among women.

Results
The committee found that from 2013-2023, only 8.8% of NIH research dollars focused on women’s health research, and that basic knowledge about women’s physiological, hormonal fluctuations, and chromosomal differences is lacking. Data are also needed to better understand diseases that are female-specific, more common in women, or affect women differently. The committee made eight recommendations for transformative change at NIH related to women’s health research.

Discussion
Overall, the report describes the need for transformative change at NIH to advance the science on women’s health research and improve outcomes. This includes a comprehensive approach and recommendations that would double the NIH’s investment in women’s health research, enhance accountability, and provide rigorous oversight, prioritization, and integration of women’s health research across NIH.
Portomesenteric Venous Thrombosis after Pancreatic Cancer Surgery with Venous Resection and Reconstruction
Authors: Ishida Hiroyuki , Watanabe Shuichi , Rodriguez Franco Salvador , Franklin Oskar , Stoop Thomas F. , Kirsch Michael J. , Schulick Richard D. , Del Chiaro Marco 
Published: December 2024

Objective:
To investigate the incidence and risk factors of portomesenteric venous thrombosis (PVT) after pancreatic cancer surgery with portomesenteric venous resection (PVR).

Summary Background Data:
Pancreatic cancer surgery with PVR can be complicated by PVT, but the long-term associations, risk factors, and consequences of PVT have not been clearly elucidated.

Methods:
This study included pancreatic cancer patients undergoing any type of pancreatic resection with PVR at the University of Colorado Hospital between January 2012 and June 2023. The study period was divided based on the implementation of local standardization of PVR techniques in August 2018. PVT was classified as early or late (≤ or >30 d postoperatively). Risk factors for late PVT were assessed with Cox regression models.

Results:
Among 152 patients, 3.3% (n=5) developed early PVT. Its incidence decreased from 12% (n=3/25) to 1.6% (n=2/127) after technical standardization (P=0.03). Of 130 patients with available postoperative imaging, 21.5% (n=28) developed late PVT at a median of 7.4 months from surgery. Late PVT was frequently diagnosed with local recurrence (75%) and was associated with shorter recurrence-free survival (median 9.0 vs. 16.3 mo, P=0.014). Multivariable analysis showed that neoadjuvant radiotherapy (hazard ratio [HR], 2.19; 95% CI, 1.02-4.67) and local recurrence (HR, 5.21; 95% CI, 2.18-12.4) were associated with an increased risk of late PVT.

Conclusions:
Early PVT after pancreatectomy with PVR is rare. Late PVT is associated with neoadjuvant radiotherapy and local recurrence. These findings may inform risk assessment in pancreatic cancer patients undergoing PVR.
Trends in the Management and Outcomes of Neuroendocrine Liver Metastases
Authors: Frilling Andrea , Clift Ashley K. , Kaemmerer Daniel , Steinkraus Kira C. , Schrader Joerg , Wolter Stefan , Drymousis Panagiotis , Liedke Marc-Olaf , Hommann Merten , Habib Nagy , Baum Richard P. , Wasan Harpreet , Modlin Irvin M. , Izbicki Jakob R. 
Published: December 2024

Objective:
To describe the evolution of management strategies for neuroendocrine liver metastases (NE LM) and trends in patient outcomes over the preceding 3 decades.

Summary Background Data:
Liver metastases are common in neuroendocrine neoplasms and impair prognosis. A broad therapeutic armamentarium has evolved over recent decades but there remains uncertainty regarding optimal treatment selection and sequencing.

Methods:
Retrospective cohort study pooling data from 4 specialist centres of excellence in the United Kingdom and Germany for individuals diagnosed with neuroendocrine liver metastases between 1st Jan 1990 and 31st December 2020. We explored trends in theranostic strategies over three decades and quantified overall survival (cohort, and by decade-defined temporal periods).

Results:
We identified 551 individuals with NE LM with a median age at diagnosis of 59.1 years; 453 (82.2%) had synchronous metastases, and 402 (73.0%) underwent multimodal therapy. In all centres somatostatin receptor-based PET/CT and MRI were the preferred imaging techniques. There were significant trends in the use of somatostatin analogues and peptide receptor radionuclide therapy but the number of surgical resections remained stable. Overall survival (OS) at 5- and 10-years was 77.5% and 58.1% respectively. Across the three time periods, 5-year OS significantly improved - period I: 45.2%, period II: 66.0%, and period III: 75.7%. Ten-year OS showed overlapping confidence intervals for Period I (23.5%) and Period II (18.3%) but doubled in period III (55.5%). On multivariate analysis, the use of multimodal therapy strategies was significantly associated with improved overall survival (HR=0.59, 95% CI: 0.40 to 0.88, P=0.009).

Conclusions:
Improved imaging modalities and modifications in specific therapies as components of multimodal treatment concepts are concordant with significantly improved survival outcomes in NELM over 30 years. The use of multimodal therapy improved overall survival in patients with NE LM. Future studies should determine optimal treatment selection and sequencing, and role of novel biomarkers to guide these.
Biochemical, Radiographic, or Pathologic Response to Neoadjuvant Chemotherapy in Resected Pancreatic Cancer
Authors: Ahmad M. Usman , Javadi Christopher S. , Chang Julia D. , Forgó Erna , Delitto Daniel J. , Dua Monica M. , Fisher George A. , Heestand Gregory M. , Chang Daniel T. , Pollom Erqi , Vitzthum Lucas K. , Kirane Amanda , Lee Byrne , Visser Brendan C. , Norton Jeffrey A. , Poultsides George A. 
Published: December 2024

Objective:
To examine the optimal method of assessing response to neoadjuvant therapy (NAT) in operable pancreatic ductal adenocarcinoma (PDAC) patients.

Summary of Background Data:
PDAC response to NAT is measured with biochemical, radiographic and pathologic parameters, which can often be discordant with each other.

Methods:
PDAC patients undergoing resection after NAT at a single institution were retrospectively analyzed. Tumor response was assessed using pre-/post-NAT Carbohydrate Antigen 19-9 (CA 19-9) levels, radiographic decrease in tumor diameter, and pathologic Tumor Regression Grade (TRG). The association of these factors with overall survival (OS) was compared using Kaplan-Meier, Cox regression, and recursive partitioning analysis (RPA), a machine learning technique that can validate prediction models for complex hierarchical relationships.

Results:
From 2011 to 2022, 225 patients underwent pancreatectomy after NAT (Folfirinox, 70%; Gem+nab-paclitaxel, 19%; radiation, 18%). Almost half required vascular resection (portal vein, 39%; celiac axis 8%). Improved OS was observed after CA 19-9 decrease >50% (32 vs. 24 mo, P=0.0028), but not after major pathologic (TRG 0-1, P=0.067) or radiographic response (tumor diameter decrease >30%, P=0.89). However, RPA identified that the co-existence of biochemical and major pathologic response (achieved in 9% of patients) was associated with the longest OS (40 mo, P=0.0086). This optimal dual response combination was more commonly observed after neoadjuvant radiotherapy was used after systemic chemotherapy (45% vs. 11%, P<0.001).

Conclusions:
CA19-9 response to NAT alone is not enough to identify long-term post-resection PDAC survivors. The co-existence of CA19-9 and major pathologic response was predictive of the most optimal survival outcome.
Study of Clostridioides difficile associated diarrheain Acute care areas of atertiary care centre in Western Rajasthan-a prospective study
Authors: Roy Nithya S , Kombade Sarika Prabhakar , Abhishek Kumar S , Singh Kuldeep , Kothari Nikhil , Khera Daisy , Kumar Deepak 
Published: December 2024

Purpose
The aim of this study is to identify Clostridioides difficile associated diarrhoea (CDAD) in patients admitted to acute care units of the hospital

Materials and Method
Cross sectional study conducted in the Department of microbiology over 2 years. Patients >1 year of age, who were admitted and passing atleast 3 unformed stool over 24 hours, with history of taking antibiotics were included in the study. A stool sample of included patients were collected, a part of sample for anaerobic culture and another part for serology by Glutamate Dehydrogenase (GDH) ELISA and Toxin A/B Elisa for C. difficile. Identification of isolate was done by MALDI TOF. Result was analysed by statistical methods.

Result
Out of 180 suspected cases of Antibiotic Associated Diarrhea (AAD), 95(52.8%) were males and rest females. Maximum cases were in age group, above 60 years (27.8%) & 51 to 60 years (15.6%). Majority of suspected cases (63.3%) had history of Beta Lactam-Beta lactamase Inhibitor (BL-BLI) followed by Carbapenems and Cephalosporins. Out of the 180 samples, GDH ELISA detected 29 (16%) to have C difficile, of which Toxin A/B ELISA detected toxin in 5 (2.8%) samples. Isolation of Clostridioides difficile from culture was positive in 3 (1.7%) in anaerobic culture. Thus, the prevalence was calculated as 2.8%.

Conclusion
This study in Western Rajasthan underscores the paramount importance of early CDAD detection and management to forestall fatal complications and mortality in critically ill patients, while fostering prudent antibiotic utilization and fortifying antimicrobial stewardship practices in hospital setting.
Super Resolved Structural Imaging of Mitochondrial Network using Orange Emissive Carbon Nanodot as Fluorescent Probe
Authors: Garg Richa , Kundu Runmi , Kaushik Kush , Salam Abdul , Nandi Chayan Kanti 
Published: December 2024

AbstractSuper-resolution microscopy (SRM), coupled with appropriate bright and photostable fluorescent probes, has revolutionized the ability to study organelle dynamics with unprecedented spatial and temporal resolution. An increasing trend of designing nanomaterial probes that has unprecedented advantages over the organic molecular probes has become the frontier in SRM based imaging of subcellular organelles. Herein, we report the development of orange-emissive fluorescent carbon nanodots (CNDs) via a one-pot synthesis that has excellent capabilities to target mitochondria. Spectroscopic analysis confirms the presence of guanidine on the surface of CNDs, thus facilitating its ability to selectively target mitochondria. The CNDs were highly capable for the super resolution radial fluctuation (SRRF) imaging of mitochondrial network and the morphology. The synthesized CNDs exhibited excellent photoluminescent properties along with high biocompatibility and non-toxicity, which could be used for their application in mitochondria-based imaging modalities.
Measurement of the
B8
solar neutrino flux using the full
SNO+
water phase dataset
Authors: Allega A. , Anderson M. R. , Andringa S. , Askins M. , Asner D. M. , Auty D. J. , Bacon A. , Barão F. , Barros N. , Bayes R. , Beier E. W. , Bialek A. , Biller S. D. , Blucher E. , Caden E. , Callaghan E. J. , Chen M. , Cheng S. , Cleveland B. , Cookman D. , Corning J. , Cox M. A. , Dehghani R. , Deloye J. , Depatie M. M. , Di Lodovico F. , Dima C. , Dittmer J. , Dixon K. H. , Esmaeilian M. S. , Falk E. , Fatemighomi N. , Ford R. , Gaur A. , González-Reina O. I. , Gooding D. , Grant C. , Grove J. , Hall S. , Hallin A. L. , Hallman D. , Heintzelman W. J. , Helmer R. L. , Hewitt C. , Hreljac B. , Hu J. , Huang P. , Hunt-Stokes R. , Hussain S. M. A. , Inácio A. S. , Jillings C. J. , Kaluzienski S. , Kaptanoglu T. , Kladnik J. , Klein J. R. , Kormos L. L. , Krar B. , Kraus C. , Krauss C. B. , Kroupová T. , Lake C. , Lebanowski L. , Lefebvre C. , Lozza V. , Luo M. , Maio A. , Manecki S. , Maneira J. , Martin R. D. , McCauley N. , McDonald A. B. , Milton G. , Morris D. , Mubasher M. , Naugle S. , Nolan L. J. , O’Keeffe H. M. , Orebi Gann G. D. , Page J. , Paleshi K. , Parker W. , Paton J. , Peeters S. J. M. , Pickard L. , Quenallata B. , Ravi P. , Reichold A. , Riccetto S. , Rose J. , Rosero R. , Semenec I. , Simms J. , Skensved P. , Smiley M. , Svoboda R. , Tam B. , Tseng J. , Vázquez-Jáuregui E. , Virtue C. J. , Ward M. , Wilson J. R. , Wilson J. D. , Wright A. , Yang S. , Yeh M. , Ye Z. , Yu S. , Zhang Y. , Zuber K. , Zummo A. ,   <math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><mrow><mi>SNO</mi><mo>+</mo></mrow></math> Collaboration
Published: December 2024

The SNO+ detector operated initially as a water Cherenkov detector. The implementation of a sealed cover gas system midway through water data taking resulted in a significant reduction in the activity of Rn222 daughters in the detector and allowed the lowest background to the solar electron scattering signal above 5 MeV achieved to date. This paper reports an updated SNO+ water phase B8 solar neutrino analysis with a total livetime of 282.4 days and an analysis threshold of 3.5 MeV. The B8 solar neutrino flux is found to be (2.32−0.17+0.18(stat)−0.05+0.07(syst))×106  cm−2 s−1 assuming no neutrino oscillations, or (5.36−0.39+0.41(stat)−0.16+0.17(syst))×106  cm−2 s−1 assuming standard neutrino oscillation parameters, in good agreement with both previous measurements and standard solar model calculations. The electron recoil spectrum is presented above 3.5 MeV.

Published by the American Physical Society
2024
More than meets the eye: the interplay of spending and product variety in organic shopping
Authors: Mata Pedro , Buil Tamar 
Published: December 2024

PurposeThis study investigates the growing global interest in organic food by examining the relationship between consumer spending patterns and the variety of organic product categories within shopping baskets. Expanding on prior research on intrinsic motivations for choosing organic products, this paper introduces differences between consumers based on their spending levels and the quantity and type – fresh vs processed – of organic products they purchase.Design/methodology/approachA descriptive analysis was conducted using data from an online panel survey in Spain, targeting regular consumers of ecological products. A total of 627 respondents were surveyed (e = 4%, N.C. = 95%; p = q = 0.5). Consumers were segmented based on the quantity of organic product categories in their baskets. The data were analysed using cross-tabulation, t-tests, and one-way ANOVA to identify significant differences in spending and product variety.FindingsThe study identified significant differences in spending patterns and in the variety of organic products purchased between the eco-consumer segments – essential, mindful and super – characterised by the variety of product categories in their shopping baskets. These findings align with global trends in eco-friendly consumption, providing a nuanced understanding of consumer behaviour in the organic food market.Originality/valueTo our knowledge, this study is the first to explore the impact of the variety of organic product categories within a shopping basket as a segmentation factor. The research contributes a novel perspective to the literature on organic food consumption by highlighting how the count and type of products influence consumer segmentation and spending behaviour.