bluuebunny/crossref_metadata_2025_split huggingface dataset:
More Amazon than Mafia: analysing a DDoS stresser service as organised cybercrime
Authors: Musotto Roberto , Wall David S. 
Published: November 2020

AbstractThe internet mafia trope has shaped our knowledge about organised crime groups online, yet the evidence is largely speculative and the logic often flawed. This paper adds to current knowledge by exploring the development, operation and demise of an online criminal group as a case study. In this article we analyse a DDoS (Distributed Denial of Service) stresser (also known as booter) which sells its services online to enable offenders to launch attacks. Using Social Network Analysis to explore the service operations and payment systems, our findings show a central business model that is similar to legitimate e-commerce websites in the way product, price and costumers are differentiated. It also illustrates that its organisation is distributed and not hierarchical and the overall income yield is comparatively low, requiring further organisational activity to make it pay. Finally, we show that the users of the service (mainly offenders) are not only a mixed group of actors, but that it is also possible to discriminate between different levels of seriousness of offending according to the particular service they purchased.
HIV-associated Cryptococcal Meningitis: a Review of Novel Short-Course and Oral Therapies
Authors: Moeng Letumile R. , Milburn James , Jarvis Joseph N. , Lawrence David S. 
Published: November 2020

Abstract
Purpose of review
HIV-associated cryptococcal meningitis remains a significant public health problem in parts of Africa and Asia and a major cause of AIDS-related mortality, accounting for 15% of all AIDS-related deaths worldwide. Cryptococcal meningitis is uniformly fatal if untreated, and access to antifungal therapy in regions with the highest burden is often limited. Outcomes with fluconazole monotherapy are poor, and induction treatment with amphotericin B and high-dose fluconazole for 2 weeks is associated with significant drug-related toxicities and prolonged hospital admissions. This review focuses on the potential of novel short-course and oral combination therapies for cryptococcal meningitis.

Recent findings
Recent clinical trials have shown that shorter courses of amphotericin, if paired with oral flucytosine, rather than fluconazole, can achieve non-inferior mortality outcomes. In addition, an oral combination of fluconazole and flucytosine is a potential alternative. Liposomal amphotericin B may further simplify treatment; it is associated with fewer drug-related toxicities, and a recent phase II randomised controlled trial demonstrated that a single, high dose of liposomal amphotericin is non-inferior to 14 standard daily doses at clearing Cryptococcus from cerebrospinal fluid. This has been taken forward to an ongoing phase III, clinical endpoint study.

Summary
The incidence and mortality associated with cryptococcal meningitis is still unacceptably high. There is evidence supporting the use of short-course amphotericin B and oral combination antifungal treatment regimens for cryptococcal meningitis (CM). Ongoing research into short-course, high-dose treatment with liposomal amphotericin may also help reduce the impact of this devastating disease.
Can early change in eating disorder psychopathology predict outcome in guided self-help for binge eating?
Authors: Jenkins Paul E. , Smith Lydia , Morgan Ceridwen 
Published: November 2020

Abstract
Purpose
This study tests the value of a measure of eating disorder (ED) psychopathology in predicting outcome following guided self-help in a non-underweight sample with regular binge eating. It examines whether early reductions in ED psychopathology are associated with remission status at post-treatment.

Methods
Seventy-two adults with bulimia nervosa, binge-eating disorder, or an atypical form of these illnesses received up to ten sessions of cognitive behaviour therapy-based guided self-help. Using a session-by-session measure of eating pathology and associated reliable change indices, response was analysed using receiver operating characteristic analysis to predict outcomes at post-treatment.

Results
In this routine care setting, nearly one-quarter of the sample achieved remission following GSH, approximately two-thirds of whom showed early change in ED psychopathology. Early change prior to session 6 was accurate in predicting later remission. Individuals showing early change did not differ from others on baseline characteristics or rates of attrition.

Conclusion
Data suggest that a majority of those who respond to treatment will do so before the second half of treatment, information that could be used to ensure that evidence-based treatments are used as effectively as possible.

Level of evidence
Level III.
Infection, Screening, and Psychological Stress of Health-Care Workers With COVID-19 in a Nonfrontline Clinical Department
Authors: Wang Ge , Guan Jia-Lun , Zhu Xiu-Qing , Wang Mu-Ru , Fang Dan , Wen Yue , Xie Meng , Tian De-An , Li Pei-Yuan 
Published: November 2020

AbstractObjectives:The aim of this study was to investigate risk factors and psychological stress of health-care workers (HCWs) with coronavirus disease 2019 (COVID-19) in a nonfrontline clinical department.Methods:Data of 2 source patients and all HCWs with infection risk were obtained in a department in Wuhan from January to February 2020. A questionnaire was designed to evaluate psychological stress of COVID-19 on HCWs.Results:The overall infection rate was 4.8% in HCWs. Ten of 25 HCWs who contacted with 2 source patients were diagnosed with confirmed COVID-19 (8/10) and suspected COVID-19 (2/10). Other 2 HCWs were transmitted by other patients or colleagues. Close care behaviors included physical examination (6/12), life nursing (4/12), ward rounds (4/12), endoscopic examination (2/12). Contacts fluctuated from 1 to 24 times and each contact was short (8.1 min ± 5.6 min). HCWs wore surgical masks (11/12), gloves (7/12), and isolation clothing (3/12) when providing medical care. Most HCWs experienced a mild course with 2 asymptomatic infections, taking 9.8 d and 20.9 d to obtain viral shedding and clinical cure, respectively. Psychological stress included worry (58.3%), anxiety (83.3%), depression (58.3%), and insomnia (58.3%).Conclusions:Close contact with COVID-19 patients and insufficient protection were key risk factors. Precaution measures and psychological support on COVID-19 is urgently required for HCWs.
How to Set Up Central Isolation Sites to Prevent Re-outbreaks From Imported Cases of COVID-19: The Experience of Shanghai, China
Authors: Zhang Wei , Ge Zhiru , Lu Jide , Wang Hairong , Yang Yawei 
Published: November 2020

AbstractAs strict measures were taken, the coronavirus disease 2019 (COVID-19) epidemic has been gradually brought under control. As a port city, Shanghai’s main problem has shifted from treating local cases to preventing foreign imports. To prevent the re-outbreak of COVID-19 caused by imported cases, the Shanghai government has set up central isolation sites for all people entering the country from abroad to be placed under medical observation. This report describes how to set up central isolation sites and run them effectively. We put isolation sites in transformed hotels, arranged personnel according to a huge data network, and set up specific procedures to manage guests. The epidemic situation in Shanghai has confirmed the feasibility and effectiveness of the methods that other jurisdictions can adapt for their use.
The integral cohomology of the Hilbert scheme of points on a surface
Authors: Totaro Burt 
Published: November 2020

Abstract
We show that if X is a smooth complex projective surface with torsion-free cohomology, then the Hilbert scheme

$X^{[n]}$

has torsion-free cohomology for every natural number n. This extends earlier work by Markman on the case of Poisson surfaces. The proof uses Gholampour-Thomas’s reduced obstruction theory for nested Hilbert schemes of surfaces.
The bandwidth theorem for locally dense graphs
Authors: Staden Katherine , Treglown Andrew 
Published: November 2020

Abstract
The bandwidth theorem of Böttcher, Schacht, and Taraz [Proof of the bandwidth conjecture of Bollobás andKomlós, Mathematische Annalen, 2009] gives a condition on the minimum degree of an n-vertex graph G that ensures G contains every r-chromatic graph H on n vertices of bounded degree and of bandwidth

$o(n)$

, thereby proving a conjecture of Bollobás and Komlós [The Blow-up Lemma, Combinatorics, Probability, and Computing, 1999]. In this paper, we prove a version of the bandwidth theorem for locally dense graphs. Indeed, we prove that every locally dense n-vertex graph G with

$\delta (G)> (1/2+o(1))n$

contains as a subgraph any given (spanning) H with bounded maximum degree and sublinear bandwidth.
Criminalising deceptive sex: sex, identity and recognition
Authors: Kennedy Chloë 
Published: November 2020

AbstractThis paper is concerned with when, if ever, deceptive sex should be criminalised. It defends the idea that it is necessary to distinguish between deceptions that will generally be punishable from those that will not and puts forward a novel framework for carrying out this task. Based on the concept of identity nonrecognition, this framework also offers a new way of understanding what makes certain kinds of deceptive sex wrongful. After setting out this framework, I analyse each of the deceptions that is most often carried out within ‘ordinary’ contexts, explaining why only some of these should generally be punished. The paper concludes by suggesting that identity nonrecognition has the potential to inform criminalisation debates more generally, and that its relevance extends beyond discussions about deceptive sex.
Skeletal mass indices are inversely associated with metabolically unhealthy phenotype in overweight/obese and normal-weight men: a population-based cross-sectional study
Authors: Carvalho Cristiane Junqueira de , Longo Giana Zarbato , Kakehasi Adriana Maria , Pereira Patrícia Feliciano , Segheto Kátia Josiany , Juvanhol Leidjaira Lopes , Ribeiro Andréia Queiroz 
Published: November 2020

AbstractMuscle mass may play an important role in the metabolic profile of individuals with or without excess weight. Metabolic phenotypes classify individuals as healthy or unhealthy based on certain metabolic conditions. We investigated the association between skeletal mass indices (SMI) and the metabolically unhealthy phenotype in normal-weight and overweight/obese adults. A total of 660 adults aged 20 to 59 years were assessed by a population-based cross-sectional study. Muscle mass of the limbs or appendicular lean mass (ALM) adjusted for weight (SMIweight) and BMI (SMIBMI) was used to evaluate SMI. Logistic regression was employed to estimate the association between SMIweight, SMIBMI and metabolic phenotypes of normal-weight and overweight/obese individuals. Metabolically unhealthy individuals were older in both sexes. Metabolically unhealthy men had lower SMI values and higher fat percentage than metabolically healthy men. SMIweight was inversely associated with the metabolically unhealthy phenotype, both in normal-weight men (OR 0·49, 95 % CI 0·24, 0·99, P = 0·04) and in overweight/obese men (OR 0·32, 95 % CI 0·16, 0·64, P = 0·001). SMIBMI was inversely associated with the metabolically unhealthy phenotype in overweight/obese men (OR 0·36, 95 % CI 0·18, 0·72, P = 0·004), but not in normal-weight men (OR 0·70, 95 % CI 0·34, 1·43, P = 0·33). Among women, SMI showed no significant association with the phenotypes. In conclusion, the SMI are inversely associated with the metabolically unhealthy phenotype in men, especially among overweight/obese men.
Higher adherence to an empirically derived Mediterranean dietary pattern is positively associated with telomere length: the Seguimiento Universidad de Navarra (SUN) project
Authors: Ojeda-Rodríguez Ana , Zazpe Itziar , Alonso-Pedrero Lucia , Zalba Guillermo , Martínez-González Miguel A. , Marti Amelia 
Published: November 2020

AbstractTelomere integrity is influenced by oxidative stress. Also, inflammation-related factors, including nutritional factors, could modulate telomere integrity. The relationship between a posteriori-derived dietary patterns and telomere length (TL) has been scarcely investigated. Thus, our objective was to examine the association between empirically derived dietary patterns ascertained through principal component analysis (PCA) and TL in an older adult Spanish population. A total of 886 older adults (>55 years old; 645 males and 241 females) from the Seguimiento Universidad de Navarra (SUN) cohort were included in the study. TL was measured by monochrome multiplex real-time quantitative PCR. Age-adjusted TL was used for all analyses. Dietary patterns were identified by PCA based on thirty predefined candidate food groups collected from a validated 136-food items frequency questionnaire. Generalised linear models were fitted to obtain β-coefficients and their 95 % CI evaluating differences in TL between each of the four upper quintiles of adherence to dietary patterns and the lowest quintile. Sensitivity analyses by rerunning all multiple linear models under different stratifications were performed to evaluate the robustness of our results. Two major dietary patterns were empirically identified, Western dietary pattern (WDP) and Mediterranean dietary pattern (MDP). After adjustment for potential confounders, longer TL was found among subjects in the highest quintile of MDP (β = 0·064; 95 % CI 0·004, 0·123). The WDP showed no significant association with TL. In conclusion, higher adherence to a posteriori-derived MDP was independently associated with longer telomeres in an older adult Spanish population of the SUN project.
Recent consumption of a caffeine-containing beverage and serum biomarkers of cardiometabolic function in the UK Biobank
Authors: Cornelis Marilyn C. 
Published: November 2020

AbstractWe investigated the impact of recent caffeine drinking on glucose and other biomarkers of cardiometabolic function under free-living conditions while also accounting for lifestyle and genetic factors that alter caffeine metabolism and drinking behaviour. Up to 447 794 UK Biobank participants aged 37–73 years in 2006–2010 provided a non-fasting blood sample, for genetic and biomarker measures, and completed questionnaires regarding sociodemographics, medical history and lifestyle. Caffeine drinking (yes/no) about 1 h before blood collection was also recorded. Multivariable regressions were used to examine the association between recent caffeine drinking and serum levels of glycated Hb, glucose, lipids, apo, lipoprotein(a) and C-reactive protein. Men and women reporting recent caffeine drinking had clinically and significantly higher glucose levels than those not recently drinking caffeine (P < 0·0001). Larger effect sizes were observed among those 55+ years of age and with higher adiposity and longer fasting times (P ≤ 0·02 for interactions). Significant CYP1A2 rs2472297×caffeine and MLXIPL rs7800944 × caffeine interactions on glucose levels were observed among women (P = 0·004), with similar but non-significant interactions in men. Larger effect sizes were observed among women with rs2472297 CC or rs7800944 CC genotypes than among rs2472297 T or rs7800944 T carriers, respectively. In summary, men and women drinking caffeine within about 1 h of blood draw had higher glucose levels than those not drinking caffeine. Findings were modified by age, adiposity, fasting time and genetic factors related to caffeine metabolism and drinking behaviour. Implications for clinical and population studies of caffeine-containing beverages and cardiometabolic health are discussed.
Effects of starvation and refeeding on growth performance, appetite, growth hormone–insulin-like growth factor axis levels and digestive function of Acipenser dabryanus
Authors: Wu Xiao-yun , Chen Ye-yu , Lai Jian-sheng , Liu Ya , Song Ming-jiang , Gong Quan , Long Zhi-hai 
Published: November 2020

AbstractThe aim of this study was to explore the effects and mechanisms of different starvation treatments on the compensatory growth of Acipenser dabryanus. A total of 120 fish (60·532 (sem 0·284) g) were randomly assigned to four groups (fasting 0, 3, 7 or 14 d and then refed for 14 d). During fasting, middle body weight decreased significantly with prolonged starvation. The whole-body and muscle composition, serum biochemical indexes, visceral indexes and digestive enzyme activities had been effected with varying degrees of changes. The growth hormone (GH) level in serum was significantly increased in 14D; however, insulin-like growth factor-1 (IGF-1) showed the opposite trend. The neuropeptide Y (npy) mRNA level in brain was significantly improved in 7D; peptide YY (pyy) mRNA level in intestine was significantly decreased during fasting. After refeeding, the final body weight, percentage weight gain, specific growth rate, feed intake, feed efficiency and protein efficiency ratio showed no difference between 0D and 3D. The changes of whole-body and muscle composition, serum biochemical indexes, visceral indexes and digestive enzyme activities had taken place in varying degrees. GH levels in 3D and 7D were significantly higher than those in the 0D; the IGF-1 content decreased significantly during refeeding. There was no significant difference in npy and pyy mRNA levels. These results indicated that short-term fasting followed by refeeding resulted in full compensation and the physiological and biochemical effects on A. dabryanus were the lowest after 3 d of starvation and 14 d of refeeding. Additionally, compensation in A. dabryanus may be mediated by appetite genes and GH, and the degree of compensation is also affected by the duration of starvation.
Asymptotic normality in t-stack sortable permutations
Authors: Chen Xi , Mao Jianxi , Wang Yi 
Published: November 2020

AbstractIn this paper, we show that the numbers of t-stack sortable n-permutations with k − 1 descents satisfy central and local limit theorems for t = 1, 2, n − 1 and n − 2. This result, in particular, gives an affirmative answer to Shapiro's question about the asymptotic normality of the Narayana numbers.
JAMES I AND GUNPOWDER TREASON DAY
Authors: WILLIAMSON PHILIP , MEARS NATALIE 
Published: November 2020

AbstractThe assumed source of the annual early modern English commemoration of Gunpowder treason day on 5 November – and its modern legacy, ‘Guy Fawkes day’ or ‘Bonfire night’ – has been an act of parliament in 1606. This article reveals the existence of earlier orders, explains how these orders alter understandings of the origin and initial purposes of the anniversary, and provides edited transcriptions of their texts. The first order revises the accepted date for the earliest publication of the special church services used for the occasion. The second order establishes that the anniversary thanksgiving was initiated not by parliament, but by King James I; it also shows that, in a striking innovation, he issued instructions for regular mid-week commemorations throughout England and Wales, expecting the bishops to change the Church of England's preaching practices. The annual thanksgivings were not just English, but ordered also in Scotland and observed in Protestant churches in Ireland. The motives for these religious thanksgivings are placed in a Stuart dynastic context, with Scottish antecedents and a British scope, rather than in the English ‘national’ setting assigned to the anniversary by English preachers and writers and by recent historians. The parliamentary act is best explained as an outcome of tensions between the king and the House of Commons.
The prediction of resilience to alcohol consumption in youths: insular and subcallosal cingulate myeloarchitecture
Authors: Weidacker Kathrin , Kim Seung-Goo , Buhl-Callesen Mette , Jensen Mads , Pedersen Mads Uffe , Thomsen Kristine Rømer , Voon Valerie 
Published: November 2020

AbstractBackgroundThe prediction of alcohol consumption in youths and particularly biomarkers of resilience, is critical for early intervention to reduce the risk of subsequent harmful alcohol use.MethodsAt baseline, the longitudinal relaxation rate (R1), indexing grey matter myelination (i.e. myeloarchitecture), was assessed in 86 adolescents/young adults (mean age = 21.76, range: 15.75–26.67 years). The Alcohol Use Disorder Identification Test (AUDIT) was assessed at baseline, 1- and 2-year follow-ups (12- and 24-months post-baseline). We used a whole brain data-driven approach controlled for age, gender, impulsivity and other substance and behavioural addiction measures, such as problematic cannabis use, drug use-related problems, internet gaming, pornography use, binge eating, and levels of externalization, to predict the change in AUDIT scores from R1.ResultsGreater baseline bilateral anterior insular and subcallosal cingulate R1 (cluster-corrected family-wise error p < 0.05) predict a lower risk for harmful alcohol use (measured as a reduction in AUDIT scores) at 2-year follow-up. Control analyses show that other grey matter measures (local volume or fractional anisotropy) did not reveal such an association. An atlas-based machine learning approach further confirms the findings.ConclusionsThe insula is critically involved in predictive coding of autonomic function relevant to subjective alcohol cue/craving states and risky decision-making processes. The subcallosal cingulate is an essential node underlying emotion regulation and involved in negative emotionality addiction theories. Our findings highlight insular and cingulate myeloarchitecture as a potential protective biomarker that predicts resilience to alcohol misuse in youths, providing novel identifiers for early intervention.
Dynamic interplay between life events and course of psychotic disorders: 10-year longitudinal study following first admission
Authors: Donaldson Kayla R. , Jonas Katherine G. , Tian Yuan , Larsen Emmett M. , Klein Daniel N. , Mohanty Aprajita , Bromet Evelyn J. , Kotov Roman 
Published: November 2020

AbstractBackgroundLife events (LEs) are a risk factor for first onset and relapse of psychotic disorders. However, the impact of LEs on specific symptoms – namely reality distortion, disorganization, negative symptoms, depression, and mania – remains unclear. Moreover, the differential effects of negativev.positive LEs are poorly understood.MethodsThe present study utilizes an epidemiologic cohort of patients (N= 428) ascertained at first-admission for psychosis and followed for a decade thereafter. Symptoms were assessed at 6-, 24-, 48-, and 120-month follow-ups.ResultsWe examined symptom change within-person and found that negative events in the previous 6 months predicted an increase in reality distortion (β= 0.07), disorganized (β= 0.07), manic (β= 0.08), and depressive symptoms (β= 0.06), and a decrease in negative symptoms (β= −0.08). Conversely, positive LEs predicted fewer reality distortion (β= −0.04), disorganized (β= −0.04), and negative (β= −0.13) symptoms, and were unrelated to mood symptoms. A between-person approach to the same hypotheses confirmed that negative LEs predicted change in all symptoms, while positive LEs predicted change only in negative symptoms. In contrast, symptoms rarely predicted future LEs.ConclusionsThese findings confirm that LEs have an effect on symptoms, and thus contribute to the burden of psychotic disorders. That LEs increase positive symptoms and decrease negative symptoms suggest at least two different mechanisms underlying the relationship between LEs and symptoms. Our findings underscore the need for increased symptom monitoring following negative LEs, as symptoms may worsen during that time.