bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mandibular movements in children with deciduous and mixed dentition and in young adults with permanent dentition—the association between movements and occlusal traits
Authors: Sepp Hettel , Vinkka-Puhakka Heli , Peltomäki Timo 
Published: April 2020

Summary

Background
Cross-sectional studies of mandibular movements provide data on developmental trends of dentition and support planning of public health services.

Objective
The aim of this study was to measure mandibular movement capacities in children with deciduous and mixed dentition and in young adults with permanent dentition. The influence of age and gender on mandibular movements and the association between mandibular movements and occlusal traits were analysed.

Method
The sample consisted of 1172 Estonians: group 1: children with deciduous dentition; group 2: children with mixed dentition; and group 3: young adults with permanent dentition. Maximum opening, mandibular laterotrusion, and protrusion were registered.

Results
Age was correlated with mandibular movements. Young adults had statistically significantly larger mandibular movements as compared to children with deciduous and mixed dentition, and children with mixed dentition had larger mandibular movements as compared to children with deciduous dentition. Young adult males had larger mandibular movements than females of the same age. Associations were found between mandibular movement capacities and some occlusal traits. Mandibular movement capacities were smaller in children with crossbite and open bite as compared with children without corresponding occlusal traits. Mandibular movement capacities were larger in children with deep bite and increased overjet as compared with those without corresponding occlusal traits.

Conclusion
Mandibular movement capacities are age and gender dependent. Maximum mouth opening, mandibular laterotrusion, and protrusion are related, and mandibular movement and some occlusal traits are associated.
The Lipomyces starkeyi gene Ls120451 encodes a cellobiose transporter that enables cellobiose fermentation in Saccharomyces cerevisiae
Authors: de Ruijter Jorg C , Igarashi Kiyohiko , Penttilä Merja 
Published: April 2020

ABSTRACT
Processed lignocellulosic biomass is a source of mixed sugars that can be used for microbial fermentation into fuels or higher value products, like chemicals. Previously, the yeast Saccharomyces cerevisiae was engineered to utilize its cellodextrins through the heterologous expression of sugar transporters together with an intracellular expressed β-glucosidase. In this study, we screened a selection of eight (putative) cellodextrin transporters from different yeast and fungal hosts in order to extend the catalogue of available cellobiose transporters for cellobiose fermentation in S. cerevisiae. We confirmed that several in silico predicted cellodextrin transporters from Aspergillus niger were capable of transporting cellobiose with low affinity. In addition, we found a novel cellobiose transporter from the yeast Lipomyces starkeyi, encoded by the gene Ls120451. This transporter allowed efficient growth on cellobiose, while it also grew on glucose and lactose, but not cellotriose nor cellotetraose. We characterized the transporter more in-depth together with the transporter CdtG from Penicillium oxalicum. CdtG showed to be slightly more efficient in cellobiose consumption than Ls120451 at concentrations below 1.0 g/L. Ls120451 was more efficient in cellobiose consumption at higher concentrations and strains expressing this transporter grew slightly slower, but produced up to 30% more ethanol than CdtG.
Application of Selected Muscle Strength and Body Mass Cut Points for the Diagnosis of Sarcopenia in Men and Women With or at Risk for HIV Infection
Authors: Erlandson Kristine M , Travison Thomas G , Zhu Hao , Magaziner Jay , Correa-de-Araujo Rosaly , Cawthon Peggy M , Bhasin Shalender , Manini Todd , Fielding Roger A , Palella Frank J , Kingsley Lawrence , Lake Jordan E , Sharma Anjali , Tien Phyllis C , Weber Kathleen M , Yin Michael T , Brown Todd T 
Published: April 2020

AbstractBackgroundPersons with HIV may experience greater mobility limitations than uninfected populations. Accurate tools are needed to identify persons at greatest risk of decline. We evaluated the performance of novel muscle weakness metrics (grip, grip/body mass index [BMI], grip/weight, grip/total body fat, grip/arm lean mass) and association with slowness and falls in older persons with or at risk for HIV infection as part of the work of the Sarcopenia Definitions and Outcomes Consortium (SDOC).MethodsWe assessed the prevalence of sarcopenia among 398 men (200 HIV+, 198 HIV−) from the Multicenter AIDS Cohort Study and 247 women (162 HIV+, 85 HIV−) from the Women’s Interagency HIV Study using previously validated muscle weakness metrics discriminative of slowness. Sensitivity and specificity were used to compare new muscle weakness and slowness criteria to previously proposed sarcopenia definitions.ResultsThe prevalence of muscle weakness ranged from 16% to 66% among men and 0% to 47% among women. Grip/BMI was associated with slowness among men with HIV only. Grip/BMI had low sensitivity (25%–30%) with moderate to high specificity (68%–89%) for discriminating of slowness; all proposed metrics had poor performance in the discrimination of slowness (area under the curve [AUC] &lt; 0.62) or fall status (AUC &lt; 0.56). The combination of muscle weakness and slowness was not significantly associated with falls (p ≥ .36), with a low sensitivity in identifying those sustaining one or more falls (sensitivity ≤ 16%).DiscussionClinical utility of new sarcopenia metrics for identification of slowness or falls in men and women with or at risk for HIV is limited, given their low sensitivity.
Probiotic Supplementation Improves Cognitive Function and Mood with Changes in Gut Microbiota in Community-Dwelling Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial
Authors: Kim Chong-Su , Cha Jiah , Sim Minju , Jung Sungwoong , Chun Woo Young , Baik Hyun Wook , Shin Dong-Mi 
Published: April 2020

Abstract
Probiotics have been proposed to ameliorate cognitive impairment and depressive disorder via the gut–brain axis in patients and experimental animal models. However, the beneficial role of probiotics in brain functions of healthy older adults remains unclear. Therefore, a randomized, double-blind, and placebo-controlled multicenter trial was conducted to determine the effects of probiotics on cognition and mood in community-dwelling older adults. Sixty-three healthy elders (≥65 years) consumed either placebo or probiotics containing Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI for 12 weeks. The gut microbiota was analyzed using 16S rRNA sequencing and bioinformatics. Brain functions were measured using the Consortium to Establish a Registry for Alzheimer’s disease, Satisfaction with life scale, stress questionnaire, Geriatric depression scale, and Positive affect and negative affect schedule. Blood brain-derived neurotrophic factor (BDNF) was determined using enzyme-linked immunosorbent assay. Relative abundance of inflammation-causing gut bacteria was significantly reduced at Week 12 in the probiotics group (p &lt; .05). The probiotics group showed greater improvement in mental flexibility test and stress score than the placebo group (p &lt; .05). Contrary to placebo, probiotics significantly increased serum BDNF level (p &lt; .05). Notably, the gut microbes significantly shifted by probiotics (Eubacterium and Clostridiales) showed significant negative correlation with serum BDNF level only in the probiotics group (RS = −0.37, RS = −0.39, p &lt; .05). In conclusion, probiotics promote mental flexibility and alleviate stress in healthy older adults, along with causing changes in gut microbiota. These results provide evidence supporting health-promoting properties of probiotics as a part of healthy diet in the older adults.
A Geroscience Perspective on COVID-19 Mortality
Authors: Promislow Daniel E L 
Published: April 2020

AbstractA novel coronavirus, SARS-CoV-2, emerged in December 2019, leading within a few months to a global pandemic. COVID-19, the disease caused by this highly contagious virus, can have serious health consequences, though risks of complications are highly age-dependent. Rates of hospitalization and death are less than 0.1% in children, but increase to 10% or more in older people. Moreover, at all ages, men are more likely than women to suffer serious consequences from COVID-19. These patterns are familiar to the geroscience community. The effects of age and sex on mortality rates from COVID-19 mirror the effects of aging on almost all major causes of mortality. These similarities are explored here, and underscore the need to consider the role of basic biological mechanisms of aging on potential treatment and outcomes of COVID-19.
Novel endo-β-N-acetylglucosaminidases from Tannerella species hydrolyze multibranched complex-type N-glycans with different specificities
Authors: Takashima Shou , Kurogochi Masaki , Osumi Kenji , Sugawara Shu-ichi , Mizuno Mamoru , Takada Yoshio , Amano Junko , Matsuda Akio 
Published: April 2020

AbstractEndo-β-N-acetylglucosaminidases are enzymes that hydrolyze the N,N′-diacetylchitobiose unit of N-glycans. Many endo-β-N-acetylglucosaminidases also exhibit transglycosylation activity, which corresponds to the reverse of the hydrolysis reaction. Because of these activities, some of these enzymes have recently been used as powerful tools for glycan remodeling of glycoproteins. Although many endo-β-N-acetylglucosaminidases have been identified and characterized to date, there are few enzymes that exhibit hydrolysis activity toward multibranched (tetra-antennary or more) complex-type N-glycans on glycoproteins. Therefore, we searched for novel endo-β-N-acetylglucosaminidases that exhibit hydrolysis activity toward multibranched complex-type N-glycans in this study. From database searches, we selected three candidate enzymes from Tannerella species—Endo-Tsp1006, Endo-Tsp1263 and Endo-Tsp1457—and prepared them as recombinant proteins. We analyzed the hydrolysis activity of these enzymes toward N-glycans on glycoproteins and found that Endo-Tsp1006 and Endo-Tsp1263 exhibited hydrolysis activity toward complex-type N-glycans, including multibranched N-glycans, preferentially, whereas Endo-Tsp1457 exhibited hydrolysis activity toward high-mannose-type N-glycans exclusively. We further analyzed substrate specificities of Endo-Tsp1006 and Endo-Tsp1263 using 18 defined glycopeptides as substrates, each having a different N-glycan structure. We found that Endo-Tsp1006 preferred N-glycans with galactose or α2,6-linked sialic acid residues in their nonreducing ends as substrates, whereas Endo-Tsp1263 preferred N-glycans with N-acetylglucosamine residues in their nonreducing ends as substrates.
Is liposomal bupivacaine superior to standard bupivacaine for pain control following minimally invasive thoracic surgery?
Authors: Yang Zhang , Zhao Liang , Li Shuangjiang , Liu Junhua 
Published: April 2020

SummaryA best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was whether regional liposomal bupivacaine was superior to standard bupivacaine for pain control following minimally invasive thoracic surgery. Altogether 70 papers were found using the reported search, of which 5 papers represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Two of the five available studies showed a significant reduction of early narcotic consumption with the regional analgesia using liposomal bupivacaine, one showed a significantly reduced usage of opioid medication during postoperative hour 24–36 among the patients receiving liposomal bupivacaine, and 2 showed no difference in cumulative opioid consumption between the 2 regional analgesia groups. In addition, there was no associated difference in the pain severity scores or the length of hospitalization.
A convergent FV–FE scheme for the stationary compressible Navier–Stokes equations
Authors: Perrin Charlotte , Saleh Khaled 
Published: April 2020

Abstract
In this paper we prove a convergence result for a discretization of the three-dimensional stationary compressible Navier–Stokes equations assuming an ideal gas pressure law $p(\rho )=a \rho ^{\gamma }$ with $\gamma&gt; \frac{3}{2}$. It is the first convergence result for a numerical method with adiabatic exponents $\gamma $ less than $3$ when the space dimension is 3. The considered numerical scheme combines finite volume techniques for the convection with the Crouzeix–Raviart finite element for the diffusion. A linearized version of the scheme is implemented in the industrial software CALIF3S developed by the French Institut de Radioprotection et de Sûreté Nucléaire.
Localized inverse factorization
Authors: Rubensson Emanuel H , Artemov Anton G , Kruchinina Anastasia , Rudberg Elias 
Published: April 2020

Abstract
We propose a localized divide and conquer algorithm for inverse factorization $S^{-1} = ZZ^*$ of Hermitian positive definite matrices $S$ with localized structure, e.g. exponential decay with respect to some given distance function on the index set of $S$. The algorithm is a reformulation of recursive inverse factorization (Rubensson et al. (2008) Recursive inverse factorization. J. Chem. Phys., 128, 104105) but makes use of localized operations only. At each level of the recursion, the problem is cut into two subproblems and their solutions are combined using iterative refinement (Niklasson (2004) Iterative refinement method for the approximate factorization of a matrix inverse. Phys. Rev. B, 70, 193102) to give a solution to the original problem. The two subproblems can be solved in parallel without any communication and, using the localized formulation, the cost of combining their results is negligible compared to the overall cost for sufficiently large systems and appropriate partitions of the problem. We also present an alternative derivation of iterative refinement based on a sign matrix formulation, analyze the stability and propose a parameterless stopping criterion. We present bounds for the initial factorization error and the number of iterations in terms of the condition number of $S$ when the starting guess is given by the solution of the two subproblems in the binary recursion. These bounds are used in theoretical results for the decay properties of the involved matrices. We demonstrate the localization properties of our algorithm for matrices corresponding to nearest neighbor overlap on one-, two- and three-dimensional lattices, as well as basis set overlap matrices generated using the Hartree–Fock and Kohn–Sham density functional theory electronic structure program Ergo (Rudberg et al. (2018) Ergo: an open-source program for linear-scaling electronic structure. SoftwareX, 7, 107). We evaluate the parallel performance of our implementation based on the chunks and tasks programming model, showing that the proposed localization of the algorithm results in a dramatic reduction of communication costs.
Evolution of Feeding Shapes Swimming Kinematics of Barnacle Naupliar Larvae: A Comparison between Trophic Modes
Authors: Wong J Y , Chan B K K , Chan K Y K 
Published: April 2020

Synopsis
A central goal in evolutionary biology is connecting morphological features with ecological functions. For marine invertebrate larvae, appendage movement determines locomotion, feeding, and predator avoidance ability. Barnacle larvae are morphologically diverse, and the morphology of non-feeding lecithotrophic nauplii are distinct from those that are planktotrophic. Lecithotrophic larvae have a more globular body shape and simplified appendages when compared with planktotrophs. However, little is known about whether and how such morphological changes affect kinematics, hydrodynamics, and ecological functions. Here, we compared the nauplii kinematics and hydrodynamics of a lecithotrophic Rhizocephalan species, Polyascus planus, against that of the planktotrophic nauplii of an intertidal barnacle, Tetraclita japonica. High-speed, micro-particle image velocimetry analysis showed that the Polyascus nauplii swam faster and had higher amplitude and more synchronous appendage beating than the Tetraclita nauplii. This fast swimming was accompanied by a faster attenuation of induced flow with distance, suggesting reduced predation risk. Tetraclita nauplii had more efficient per beat cycles with less backward displacement during the recovery stroke. This “anchoring effect” resulted from the anti-phase beating of appendages. This movement, together with a high-drag body form, likely helps direct the suction flow toward the ventral food capturing area. In sum, the tradeoff between swimming speed and predation risks may have been an important factor in the evolution of the observed larval forms.
Study on the correlation between BMPR1B protein in sheep blood and reproductive performance
Authors: Zhang Xiaoyan , Zhang Liping , Sun Weibo , Lang Xia , Wu Jianping , Zhu Caiye , Jia Jianlei , Jin Jinpen , La Younfu , Casper David P 
Published: April 2020

Abstract
Sheep reproductive performance is one of the important economic traits in sheep farming. The bone morphogenetic protein receptor 1B (BMPR1B) gene and protein may play an important role in sheep fertility. This study was to investigate the association of blood BMPR1B protein expression with reproductive performance in sheep. Mongolian sheep with single and twin births and polytocous Small Tail Han sheep were selected due to differences in birth numbers. The BMPR1B mRNA in sheep blood was measured by a reverse transcription-polymerase chain reaction as well as the BMPR1B protein was measured by enzyme-linked immunosorbent assay in blood samples of Mongolian and Small Tail Han sheep. The results demonstrated that blood BMPR1B concentration in Mongolian sheep with twin birth was higher (P &lt; 0.05) than Small Tail Han sheep and Mongolian sheep with single birth. The protein concentration in the anestrus season was higher (P &lt; 0.045) than those in the estrus season for both Mongolian and Small Tail Han sheep. Moreover, BMPR1B concentration in Mongolian sheep increased (P &lt; 0.05) at the age of 6 to 12 mo and that in Small Tail Han sheep increased (P &lt; 0.05) at the age of 3 to 6 mo. The result indicates that the increase in BMPR1B protein concentrations in the blood of Mongolian ewes and Small Tail Han ewes may be beneficial to follicular development, but too high or too low of this blood protein concentration in Mongolian and Small Tail Han sheep is not conducive to ovulation.
Mobility and Dispersal of Two Cosmopolitan Stored-Product Insects Are Adversely Affected by Long-Lasting Insecticide Netting in a Life Stage-Dependent Manner
Authors: Wilkins Rachel V , Zhu Kun Yan , Campbell James F , Morrison William R 
Published: April 2020

Abstract
Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae) and Trogoderma variabile Ballion (Coleoptera: Dermestidae) are two stored-product insects that cause extensive damage to a variety of postharvest commodities. Long-lasting insecticide-incorporated netting (LLIN), commonly used to control vector-borne diseases in tropical regions, has only been recently studied in an agricultural setting. While prior research showed that LLIN was successful against stored-product beetles, little is known about differential susceptibility among stored-product insect life stages. The aim of this study was to evaluate LLIN efficacy against immature T. castaneum and T. variabile compared with adults. Movement and dispersal ability were evaluated after exposure to LLIN or an untreated, control netting. For the movement assay, video-tracking software recorded the postexposure effects of LLIN on distance traveled and velocity of the insects in 2-h trials. For the dispersal assay, insects were exposed to the netting then released into one end of a PVC pipe and allowed 48 h to disperse to a novel food patch located at the opposite end of the pipe. Our study found that movement and dispersal ability of T. variabile and T. castaneum are significantly reduced, often by multiple-fold, after LLIN exposure, with the larval stage of each species more tolerant to the insecticide netting than adults. These results indicate that LLIN is a promising tool for use in intercepting immigrating insects of different life stages in food facilities to protect stored products.
Collecting and Monitoring for Northern Fowl Mite (Acari: Macronyssidae) and Poultry Red Mite (Acari: Dermanyssidae) in Poultry Systems
Authors: Murillo Amy C , Mullens Bradley A 
Published: April 2020

Abstract
The two most economically important poultry ectoparasites are the northern fowl mite, Ornithonyssus sylviarum (Canestrini and Fanzago), and the poultry red mite, Dermanyssus gallinae (De Geer). Both mites are obligate blood feeders but differ in where they reside. Sampling methods thus focus on-host, especially the vent feathers, for northern fowl mite and off-host, especially cracks and crevices near the nighttime roosting areas, for poultry red mite. Much remains unknown, however, about the basic biology and ecology of both mites. Here we discuss mite detection, quantification, and decision making and provide thoughts on future directions for research.
Real-world use of temsirolimus in Japanese patients with unresectable or metastatic renal cell carcinoma: recent consideration based on the results of a post-marketing, all-case surveillance study
Authors: Sugiyama Shigeru , Sato Kazuo , Shibasaki Yoshiyuki , Endo Yutaka , Uryu Taku , Toyoshima Yasuharu , Oya Mototsugu , Miyanaga Naoto , Saijo Nagahiro , Gemma Akihiko , Akaza Hideyuki 
Published: April 2020

Abstract

Objective
A prospective, observational, post-marketing surveillance was conducted to assess the safety and effectiveness of temsirolimus in patients with renal cell carcinoma in Japan.

Methods
Patients prescribed temsirolimus for advanced renal cell carcinoma were registered and received temsirolimus (25 mg weekly, intravenous infusion for 30–60 minutes) in routine clinical settings (observation period: 96 weeks).

Results
Among 1001 patients included in the safety analysis data set (median age, 65.0 years; men, 74.8%; Eastern Cooperative Oncology Group performance status 0 or 1, 69.6%), 778 (77.7%) reported adverse drug reactions. The most common (≥10%) all-grade adverse drug reactions were stomatitis (26.7%), interstitial lung disease (17.3%) and platelet count decreased (11.1%). The incidence rate of grade ≥3 interstitial lung disease was 4.5%. The onset of interstitial lung disease was more frequent after 4–8 weeks of treatment or in patients with lower Eastern Cooperative Oncology Group performance status (21.6% for score 0 vs 8.3% for score 4, P &lt; 0.001). Among 654 patients in the effectiveness analysis data set, the response and clinical benefit rates were 6.7% (95% confidence interval 4.9–8.9) and 53.2% (95% confidence interval 49.3–57.1), respectively. The median progression-free survival was 18.3 weeks (95% confidence interval 16.9–21.1).

Conclusions
The safety and effectiveness profile of temsirolimus observed in this study was similar to that observed in the multinational phase 3 study. The results are generalizable to the real-world scenario at the time of this research, and safety and effectiveness of temsirolimus as a subsequent anticancer therapy for renal cell carcinoma warrants further investigation. (ClinicalTrials.gov identifier NCT01210482, NCT01420601).