bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tomatidine relieves neuronal damage in spinal cord injury by inhibiting the inflammatory responses and apoptosis through blocking the NF-κB/CXCL10 pathway activation
Authors: Wang Xu , Huang Wei , Sun Hao , Wang Hua , Wang Dongxu , Wang Yongxiang 
Published: December 2024

BackgroundSpinal cord injury (SCI) is a neurological disease characterized by high disability and mortality rates. Tomatidine, a natural steroid alkaloid, has been evidenced to have neuroprotective properties. However, the underlying mechanisms of tomatidine in treating SCI remain ambiguous. This study aimed to illustrate the molecular mechanisms of tomatidine in modulating the inflammatory response and promoting functional rehabilitation after SCI.MethodsSprague–Dawley (SD) rats were used to construct an in vivo SCI model and were intraperitoneally injected with tomatidine (5, 10, or 20 mg/kg) for 7 days, followed by treatment with the nuclear factor-κB (NF-κB) pathway agonist (PMA). In addition, lipopolysaccharide (LPS)-induced PC-12 cells were used to establish an SCI cell model and were stimulated with tomatidine, PMA, or a CXCL10 inhibitor. The pathophysiological changes and neurological function were evaluated using blood-brain barrier (BBB) scoring, water content determination, hematoxylin and eosin (H&amp;E) staining, and TUNEL assay. Levels of inflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, were measured. Cell proliferation, apoptosis, and the expression of C-X-C motif chemokine ligand 10 (CXCL10) were determined. Moreover, the expression of cleaved-caspase 3, caspase 3, CXCL10, p-p65, and p65 were analyzed.ResultsOur data revealed that tomatidine promoted neuronal damage recovery, reduced histopathological changes, elevated cell proliferation, and inhibited the apoptosis and inflammatory factor levels in spinal cord tissues and LPS-induced PC-12 cells. Moreover, tomatidine decreased the expression of CXCL10 in vitro and in vivo, which was accompanied by the regulation of the NF-κB pathway. However, the NF-κB pathway agonist PMA reversed the protective effect of tomatidine in vitro. PMA also enhanced the CXCL10 expression and stimulated the activation of the NF-κB pathway, as demonstrated by the upregulation of phosphorylated p65. The CXCL10 inhibitor had effects similar to tomatidine on cleaved-caspase 3 expression, CXCL10 expression, and the NF-κB pathway.ConclusionTomatidine can alleviate neuronal damage in SCI by inhibiting apoptosis and inflammation through the NF-κB/CXCL10 pathway. Our findings provide a novel therapeutic target and candidate for the treatment of SCI.
Gender differences in elementary school students’ fraction learning: roles of spatial ability and mathematical anxiety
Authors: Zhang Ruhai , Chen Zhongting , Deng Ciping 
Published: December 2024

AimIn this study, we examined gender differences in fraction learning and explored potential underlying mechanisms.MethodsThe mediating effects of spatial ability and mathematical anxiety on gender differences in fraction learning were tested in elementary school students. A total of 165 sixth-grade students (83 girls) from public elementary schools participated in the study. All participants completed a series of tasks, including a mathematical anxiety test, two spatial ability tasks (spatial working memory and mental rotation tests), and a fraction knowledge test (incorporating fraction arithmetic, fraction number line, and fraction concept knowledge).ResultsSignificant gender differences exist in student performance in terms of fractional arithmetic, fractional number line estimation, mathematical anxiety, and spatial working memory. We also identified a chain-mediating effect of spatial working memory and mathematical anxiety on the relationship between gender and fractional arithmetic.ConclusionThe findings suggest a developmental pathway linking gender differences in spatial cognition to fraction learning, contributing to a better understanding of the cognitive and affective factors underlying gender differences in fraction learning during early adolescence. Furthermore, there are several practical implications for reducing gender differences in mathematics education during school years.
Simulation of granular flows and machine learning in food processing
Authors: Cui X. , Adebayo D. , Zhang H. , Howarth M. , Anderson A. , Olopade T. , Salami K. , Farooq S. 
Published: December 2024

Granular materials are widely encountered in food processing, but understanding their behavior and movement mechanisms remains in the early stages of research. In this paper, we present our recent modeling and simulation work on chute granular flow using both the discrete element method (DEM) and continuum method. Based on the simulation data, we apply machine learning techniques such as Random Forest, Linear Regression, and Ridge Regression to evaluate the effectiveness of these models in predicting granular flow patterns. The granular materials in our study consist of soft-sphere particles with a 1 mm diameter, driven by gravity as they flow down a chute inclined relative to the horizontal plane. Our DEM and continuum simulation results show good agreement in modeling the chute flow, and the machine learning approach demonstrates promising potential for predicting flow patterns. The results of this chute flow study can provide a benchmark solution for more complex flow problems involving factors such as particle shape, size, interparticle interactions, and external obstacles.
Pilot study characterizing a single pooled preparation of equine platelet lysate for nebulization in the horse
Authors: Egli Patricia , Boone Lindsey , Huber Laura , Higgins Courtney , Gaonkar Pankaj P. , Arrington Justine , Naskou Maria C. , Peroni John , Gordon Julie , Lascola Kara M. 
Published: December 2024

IntroductionPlatelet lysate (PL) demonstrates antimicrobial and anti-inflammatory properties offering potential for treatment of bacterial pneumonia in horses. It remains unknown whether nebulization is suitable for PL administration in horses. This pilot study characterized particle size and flow rate of pooled equine PL (single preparation) nebulized using an equine-specific nebulizer (Flexivent®).MethodsProtein composition and antimicrobial activity were compared before and after nebulization. Protein composition was evaluated according to growth factor, antimicrobial peptide and cytokine concentrations and proteomic analysis. To evaluate antimicrobial activity, bacterial growth inhibition [maximum growth (μmax); carrying capacity (K)] were determined for E. coli, Streptococcus equi subsp zooepidemicus and Rhodococcus equi (WT and MDR) using pre- and post-nebulized PL concentrations of 50%.ResultsFlow rate and median particle size were 0.8 ml/min and 4.991 μm with 52% of particles ≤ 5 μm. Differences in PL protein composition were detected with nebulization. For E. coli and S. zooepidemicus, nebulization did not alter effect of PL on growth parameters. PL treatments decreased K for S. zooepidemicus (p = 0.009) compared to BHI. For R. equi K was increased post- vs. pre-nebulization (WT and MDR) and μmax increased pre- vs, post-nebulization (MDR). PL treatments increased K and μmax for MDR R. equi and μmax for WT R. equi compared to BHI (p ≤ 0.05).ConclusionNebulization of PL in vitro is technically feasible. The results of this study support further investigation to better characterize the effect of nebulization on PL and its suitability for nebulization in horses.
Developing Kenjeran as a Tourism Destination Based on Fisher Community Approach
Authors: Yunita Febri Rizma , Suharto Bambang , Isnaini Santi 
Published: December 2024

Kenjeran has strengths in the fisheries sector which has great potential to be developed as tourism with unique culinary delights, considering the abundant diversity of processed seafood. This research aims to explore opportunities for developing Kenjeran using Community-Based Tourism (CBT) theory and the 4A components, namely Attraction, Accessibility, Amenity, Ancillary. The method used in this research is a qualitative method with thematic analysis and SWOT analysis. The results of this research indicate that Kenjeran has implemented community-based tourism. However, it remains at the fifth level, namely approval, as the extent of citizen participation in decision-making is still not entirely clear. Meanwhile, the results of the SWOT analysis show that the location of the quadrant point is in a very profitable aggressive strategy (growth-oriented strategy) position. This strategy can focus on increasing local community participation, particularly through education in tourism management and governance, ensuring the fishermen’s active involvement in decision-making processes. The active fishing community is positioned as a central element in managing tourism activities, such as culinary tourism and maritime festivals. In addition, external threats like competition from other destinations and environmental concerns are addressed by adopting sustainable tourism practices, including eco-tourism and infrastructure development aligned with environmental conservation principles.
SISTEM MONITORING PEGAWAI BERDASARKAN PENUGASAN BERBASIS WEBSITE
Authors: Hanural Tabia , Pramudwiatmoko Arif 
Published: December 2024

The Cepu Oil and Gas Human Resources Development Center faces challenges in the efficiency of reporting and monitoring employee assignments due to the use of conventional methods that are prone to delays and inaccuracies in data. The impact of the absence of a web-based performance appraisal application causes obstacles in managerial decision making, decreased productivity, and increased occupational safety risks. To overcome this problem, a web-based employee performance appraisal system was developed using XAMPP, Laravel, HTML, PHP, CSS, and MySQL technologies, by applying the Waterfall Model system development method. The development process includes designing, implementing, and testing key features such as employee data input, assignments, reports, and performance appraisals by supervisors. The approach used includes quantitative analysis through questionnaires and qualitative analysis through interviews. The results show that this application has succeeded in increasing the efficiency and accuracy of reporting, enabling real-time access to data, and supporting faster and more precise decision making at the Cepu Oil and Gas Human Resources Development Center. ABSTRAKPusat Pengembangan Sumber Daya Manusia Migas Cepu menghadapi tantangan dalam efisiensi pelaporan dan monitoring penugasan pegawai akibat penggunaan metode konvensional yang rentan terhadap keterlambatan dan ketidakakuratan data. Dampak dari ketiadaan aplikasi penilaian kinerja berbasis web menyebabkan hambatan dalam pengambilan keputusan manajerial, penurunan produktivitas, dan peningkatan risiko keselamatan kerja. Untuk mengatasi masalah ini, dikembangkan sebuah sistem penilaian kinerja pegawai berbasis web menggunakan teknologi XAMPP, Laravel, HTML, PHP, CSS, dan MySQL, dengan menerapkan metode pengembangan sistem Model Waterfall. Proses pengembangan meliputi perancangan, implementasi, serta pengujian fitur-fitur utama seperti input data pegawai, penugasan, laporan, dan penilaian kinerja oleh supervisor. Pendekatan yang digunakan mencakup analisis kuantitatif melalui kuesioner dan kualitatif melalui wawancara. Hasil menunjukkan bahwa aplikasi ini berhasil meningkatkan efisiensi dan akurasi pelaporan, memungkinkan akses real-time terhadap data, dan mendukung pengambilan keputusan yang lebih cepat dan tepat di PPSDM Migas Cepu.
Exercise Tolerance And Pulmonary Function Among Middle Aged People With And Without Diabetes Mellitus.
Authors: Padmanabhan Suresh Babu Roshan  , Balachandra A Shetty  , Shabnam MV  
Published: December 2024

OBJECTIVE: To assess and to compare exercise tolerance and pulmonary function among middle aged persons with type 2 Diabetes Mellitus and without.
METHODS A total of 30 patients ,15 with type 2 diabetes and 15 age matched controls without diabetes recruited from a tertiary hospital, participated in the study. Exercise tolerance and pulmonary function was assessed using six -minute walk test and spirometer respectively, for both the groups.
RESULTS: In the statistical analysis, the control group was seen to fare better in all the parameters. When analysed between groups using t test, FEV1, (t=11.350, p= <0.001) FVC (t=6.249, p= <0.001), FEV1/FVC (t=13.184, p=<0.001) and 6MWT (t=11.74100, p=<0.001) was found to be significantly different between diabetic and normal group. Analysis using chi square test showed a significant difference in lung function between diabetic and non-diabetic participants.
CONCLUSION: Middle aged non-diabetic individuals showed normal performance in exercise tolerance and pulmonary function, whereas the Diabetic population had reduced exercise tolerance and pulmonary function. This implies that middle age could be a crucial stage for early prevention of decline in pulmonary function and exercise tolerance and also to prevent future complications in type 2 diabetic patients.
Effect of Mulligan’s Sustained Natural Apophyseal Glide and Positional Release Technique on Pain, Range of Motion and Headache Disability Among Subjects with Cervicogenic Headache.
Authors: J. Prakash  , Nagarani. R  , A. Yazhini  , S. Sivakumar  , Kannabiran Bhojan  
Published: December 2024

INTRODUTION: Cervicogenic headaches are unilateral frontotemporal headaches with clinical symptoms similar to migraine. A significant issue for many patients with upper cervical dysfunction is cervicogenic headache, which presents significant challenges for physical therapy management.
OBJECTIVES: To determine how well the positional release method and Mulligan’s SNAGs effect on headache disability, pain, and range of movement in cervicogenic headache patients.
METHODOLOGY:A purposive sampling strategy was used in a quasi-experimental investigation. Individuals who met the selection criteria and had a clinical diagnosis of cervicogenic headache of were chosen and two groups were formed for cervicogenic headache. Group B received a home exercise program and positional release technique, while Group A received the Mulligan’s SNAG program.
OUTCOME MEASURES: Pain, cervical rotation range of motion, headache disability index.
RESULTS: A paired "t" test and an independent "t" test were used to evaluate the data at the 5% significance level. The pre- and post-test mean values indicate a decrease in headache severity. The post-test results showed a considerable variation for the outcome variables ofpain, range of motion, and headache impairment between the two groups; nevertheless, the group showed higher gains.
CONCLUSION: According to this study, patients with cervicogenic headaches who took Mulligan’s C1-C2 sustained natural apophyseal showed improved pain relief, increased range of motion, and decreased headache disability.
Pengaruh Motivasi Belajar Terhadap Karakter Peserta Didik di Fase F
Authors: Sari Mesi Indah , Adison Joni , Usman Citra Imelda 
Published: December 2024

The existence of students who are less concerned and indifferent to the learning process, as well as the fact that many still struggle to submit assignments on time, motivates this research. The purpose of this study is to analyze the effect of learning motivation on student character in phase F at SMA Negeri 1 Luhak Nan Duo, West Pasaman Regency. This research falls under the category of quantitative descriptive. The study's population consisted of 333 students. 333 students. The study employed a proportional random sampling technique, selecting 77 students from the totThe questionnaire employed the simple linear regression analysis technique as its instrument. sis technique. The study's results indicate that student learning motivation is significantly high. The student's character falls into the very good category. It is also known that there is a significant influence of learning motivation on student character in Phase F of SMA Negeri 1 Luhak Nan Duo. Therefore, we can conclude that the hypothesis, which posits a strong influence of learning motivation on student character, stands at 83.5%. This study contributes to a deeper understanding of the importance of learning motivation in shaping student character.
Poétique du réalisme magique dans The Ventriloquist’s Tale de Pauline Melville : de la liminalité à la complexité
Authors: Gourg Claudie 
Published: December 2024

Au travers d’une saga familiale enjambant tout le XXe siècle, Pauline Melville explore la richesse et les ravages de différentes vagues de colonisation. Sa propre hybridité identitaire, comme celle de son pays, ne peuvent s’exprimer qu’au moyen du « réalisme magique ». Cet article se concentre sur les diverses techniques narratives mises en œuvre afin de transmuer ce qui est bel et bien une charge critique érudite et une dénonciation implacable, en une grande réhabilitation du mythe. La subversion esthétique par le merveilleux maîtrisé du mythe, se révèle le vecteur le plus apte à faire vivre un imaginaire en danger d’anéantissement.
Lecture du cinéma caribéen féminin francophone. L’activisme nègre et féministe de Euzhan Palcy
Authors: Toumson Yolande-Salomé 
Published: December 2024

En Martinique, Euzhan Palcy est une icône. Par delà les frontières de son île natale, elle est un véritable mythe. Sa renommée internationale est irréfutable, malgré un parcours semé d’obstacles qui évoquent le concept d’intersectionnalité de Kimberley Crenshaw : son sexe, son âge à l’époque, et son origine. Son engagement vis-à-vis de la diaspora noire est le fil conducteur qui guide ses choix narratifs et thématiques, ainsi que dans ses collaborations avec des réalisateurs africains. Cette part visible et assumée de sa pratique complexe d’auteur, dont la source est profondément inscrite dans son vécu, impose de lever les barrières qui séparent les méthodologies d’analyse du cinéma et de ses objets films, pour permettre de lever le voile sur les réseaux de signifiance, leurs enjeux. Mais il s’agit aussi de mettre au jour les échos pérennes dans les œuvres des réalisateurs de la Caraïbe insulaire francophone, jusqu’à parvenir questionnements et partis-pris esthétiques contrastés de la jeune génération des réalisateurs des années 2000.
Langues, variétés et représentations à la Dominique : état des lieux et enjeux
Authors: Royer Zephrine 
Published: December 2024

Le gouvernement de la Dominique recense seulement deux langues, l’anglais et le kwéyòl, comme langues parlées par la population. Pourtant, le peu de recherche qui existe sur les langues de la Dominique nous indique la présence de quatre langues et variétés sur l’île : l’anglais, le kwéyòl (créole à base lexicale française), le kokoy (créole à base lexicale anglaise), et l’anglais dominiquais (une variété de l’anglais dit « standard »). Les variations à l’intérieur de l’anglais dominiquais et sa ressemblance avec l’anglais dans certaines de ses formes syntaxiques et grammaticales (Christie 2010) mènent bien des individus, toutefois, à se positionner comme locuteurs de l’anglais standard. Cet article s’appuie sur les résultats de notre étude doctorale (Royer 2015) et pose la question de l’avenir et de la préservation de ces langues face à l’imposition de l’anglais comme l’unique langue d’enseignement et de communication à l’école, à l’exclusion des langues comme le kwéyòl ou le kokoy des programmes scolaires, et au nombre croissant de locuteurs monolingues de l’anglais (Christie 2010). Ces langues et variétés sont-elles alors destinées à disparaître par transformation, par extinction ou par remplacement (Calvet 1999) ?
Édouard Glissant et la jeunesse aux Antilles
Authors: Conflon Gros-Désirs Patricia 
Published: December 2024

En 1963, paraît dans la revue Présence africaine un article d’Édouard Glissant, « Problèmes de la jeunesse aux Antilles », qui s’insurge contre la politique migratoire du gouvernement français favorisant le départ massif des jeunes en France. Le BUMIDOM (BUreau des MIgrations D’Outre-Mer) était l’instrument de cette politique qui se fondait sur des motivations socio-économiques, démographiques, géographiques et sociétales. Pour Glissant, cette pratique avait pour but d’éloigner une jeunesse antillaise de plus en plus nombreuse à contester le colonialisme répressif hostile à toute velléité d’indépendance et d’insoumission. Ici, la relecture du texte de Glissant procède d’une approche transversale, à la croisée de la littérature, de la sociologie, de la politique et de l’histoire. En effet cet article est d’une actualité qui résonne plus d’un demi-siècle après sa publication. Au-delà de sa visée polémique, il frappe par sa valeur historique, politique et interpelle par ses échos prophétiques.
Raphaël Confiant et Maryse Condé : complicité, duplicité, la Créolité mord-t-elle ?
Authors: Luce Xavier 
Published: December 2024

Cet article consiste en une étude comparée des deux romans de Maryse Condé qui encadrent la parution du premier roman francophone de Raphaël Confiant, Le Nègre et l’amiral (1988), en fonction de sa critique de La Vie scélérate (1987) et de la mise en fiction de la querelle créoliste dans Traversée de la mangrove (1989). Il s’agit de dégager les points de convergence et de divergence entre Condé et Confiant tels qu’ils se manifestent entre 1987 et 1997, date de parution de l’entretien « Créolité Bites ». Au cours de celui-ci, Confiant accuse son aînée Condé, dont il loue l’écriture romanesque, de faire montre de « duplicité ». Un souci particulier est accordé au contexte de publication sur le plan à la fois littéraire et politique. Ces trois romans se caractérisent en effet par une mise en abyme du roman à travers plusieurs avatars d’écrivains confrontés à la vie culturelle et politique de la Martinique et de la Guadeloupe.
Le Visage calme de René Maran : Poïétique d’une âme exaltée
Authors: Bertin-Elisabeth Cécile 
Published: December 2024

De René Maran ne connaîtrait-on « que »… Batouala ? Il a pourtant été aussi, et avant d’être romancier, poète. On s’intéressera dans cet article au recueil poétique : Le Visage calme (1922) qui, dans sa gangue traditionnelle fort liée à son époque, transcrit toutefois déjà une façon particulière d’habiter le monde et d’y faire résonner la Nature. Ce sont ces germes d’étincelles « maraniennes » que nous interrogerons dans une analyse tant du fond que de la forme en privilégiant les signes obliques d’un dire et d’un ressentir dont le masque pourrait être présenté comme un « visage calme »…
La créolisation selon Saint-John Perse
Authors: Claverie André 
Published: December 2024

Saint-John Perse a transmué la « créolité » de ses origines antillaises en une nouvelle philosophie de l’interculturalité. Le poète présente cette « créolisation » comme une « bi-genèse » provoquée par le choc interculturel, interpersonnel, de la rencontre avec l’Étranger. Transposition de son contact avec le monde chinois, la « chanson » liminaire d’Anabase illustre cette scène critique du croisement civilisationnel incarné par deux instances personnelles réversibles : le Narrateur-Voyageur dont la subjectivité se trouve confrontée à l’extranéité de l’Autre. Cette confrontation avec l’Étranger, sublimée en transaction ontologique, suscite au plus intime du sujet une réactivation de ses forces créatrices, grâce à la découverte de sa propre extranéité — cette part d’inconnu où s’origine l’expression la plus authentique de sa singularité. Ni repli identitaire, ni métissage, la créolisation selon Saint-John Perse se révèle comme une dialectique des consciences qui vivifie les qualités intrinsèques des actants culturels, par la transmutation de leurs valeurs respectives.