bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival Benefits and Safety Profile of T ransarterial C hemoembolization (TACE) B ased Monotherapy or Multi-modal Therapies in Locally Advanced Stage Hepatocellular Carcinoma: an Observational Study from Real-World Setting
Authors: Yin Xin , Tang Bei , Zhang Feng , Hu Keshu , Yuan Jia , Li Miao , Lu Shenxin , Wang Yanhong , Chen Rongxin , Zhang Lan , Zhang Boheng , Ren Zhenggang 
Published: October 2019

Abstract
Background : Majority of patients with locally advanced hepatocellular carcinoma (HCC) in Asian-Pacific regions underwent transarterial chemoembolization (TACE) or TACE-based muti-modal treatments instead of molecular target therapy in clinical practice. We aimed to evaluate the treatment outcomes and safety of transarterial chemoembolization based multi-modal treatments in locally advanced HCC from a real-world setting. Methods: From January 2008 to December 2015, 552 patients with locally advanced HCC who received TACE based monotherapy or multi-modal treatments at Liver Cancer Institute, Zhongshan Hospital, Fudan University were retrospectively enrolled. The clinical outcome of these patients were evaluated among these treatment groups. Propensity score matching analysis was performed to reduce potential bias for comparing treatment modalities. Results: Of all the patients, 375 patients received TACE treatment, 83 patients received TACE followed Sorafenib treatment (TACE+Sorafenib), 30 patients received TACE followed local ablation treatment (TACE+LAT), and 64 patients received TACE followed radiotherapy (TACE+Radiotherapy). 1-, 3-, 5-year OS rates in TACE group were 50.5%, 29.8% and 24.5% vs. 74.3%, 46.6% and 37.6% in TACE+multi-modal treatment group (P<0.001). The median survival time was 7.5 months, 13.0 months, 16.5 months, 10.0 months for TACE alone group, TACE+Sorafenib group, TACE+LAT group, and TACE+Radiotherapy group respectively. After propensity score matching, survival benefits were verified in TACE+Sorafenib and TACE+LAT treatments group. Safety analysis showed the major adverse events rates was 3.6% in TACE alone group and 3.9% in TACE+multi-modal treatment group with no statistic difference (P=1.0). Conclusions: TACE+Sorafenib treatment or TACE+local ablation treatment could achieve superior survival benefits to TACE alone in the management of locally advanced HCC.
Teologi Guanxi: Sebuah Upaya Memahami Aspek Teologi Relasional dalam Budaya Tionghoa
Authors: Baito Linus 
Published: October 2019

This article aims at constructing a theology of business starting from the Chinese principle of relationship which is known as guanxi. Many have seen the role of guanxi in the process of China’s economic growth. Guanxi plays a philosophical role not only in economic life, but also in social as well as cultural ones. Using Robert Schreiter’s method of intercultural theology, this study finds that the philosophical concept of guanxi offers values compatible with a Christian theology of relationship. Interacting the two resources would provide a strong basis for constructing a theology of business.
Resensi Buku Relasionalitas, Filsafat Fondasi Interpretasi: Aku, Teks, Liyan, Fenomenon
Authors: Hutabarat Haleluya Timbo 
Published: October 2019

Buku yang ditulis Armada Riyanto ini menggunakan filsafat fenomenologis dalam memaknai dan memahami relasi antara 'Aku, teks, liyan, fenomen'. Cara kerja dan hasilnya, bisa dilihat dalam framework hermeneutika teks, tetapi juga studi intersubjektifitas lainnya seperti riset fenomenologis, sosiologi interpretatif, studi indentitas, penelitian sumber daya manusia, teori pendidikan, dan sosio-politis-kultural-religius kearifan lokal. Buku yang terdiri dari 10 babini memiliki banyak manfaat dan menjawab kebutuhan akademis sekaligus tantangan kemanusiaan jaman sekarang.
Constraining new physics from Higgs measurements with Lilith: update to LHC Run 2 results
Authors: Kraml Sabine , Quang Loc Tran , Nhung Dao Thi , Ninh Le Duc 
Published: October 2019

Lilith is a public Python library for constraining new physics from
Higgs signal strength measurements. We here present version 2.0 of
Lilith together with an updated XML database which includes the current
ATLAS and CMS Run 2 Higgs results for
36 fb^{-1}−1.
Both the code and the database were extended from the ordinary Gaussian
approximation employed in Lilith-1.1 to using variable Gaussian and
Poisson likelihoods. Moreover, Lilith can now make use of correlation
matrices of arbitrary dimension. We provide detailed validations of the
implemented experimental results as well as a status of global fits for
reduced Higgs couplings, Two-Higgs-doublet models of Type I and Type II,
and invisible Higgs decays. Lilith-2.0 is available on GitHub and ready
to be used to constrain a wide class of new physics scenarios.
Research on vibration displacement test method for large-caliber artillery muzzle
Authors: Li Shili , Chao Hongxiao , Wang Dongying , Ren Junlong 
Published: October 2019

In order to solve the problem of muzzle vibration displacement test of large caliber under high elevation, this paper presents a test method by two high-speed photography. The method fully considers the influence of the muzzle torsion on the measurement results, and accurately obtains the three-dimensional vibration displacement of the muzzle of the large caliber artillery. Finally, through the result analysis, the accuracy of the measurement results can reach 0.1 mm, which shows the advantage of the sub-pixel-based high-speed camera processing method in the muzzle vibration displacement test of the conventional artillery. This paper proposes an innovative test method that accurately measures the vibration displacement of the muzzle using a non-contact method.
On-site vibration test and dynamic response analysis of wind turbine of intertidal zone
Authors: Huang Shuai , Lyu Yuejun , Peng Yanju , Sha Haijun 
Published: October 2019

In our study, the vibration signal of impulse response and attenuation response are extracted using the correlation function and power spectrum, and the natural frequency of wind turbine is determined. Compared with the rotation frequency of the blades of wind turbine which are 1p (one blade) and 3p (three blades), and wind vibration performance of the wind turbine is determined. The natural frequency of wind turbine is between the frequencies of one blade and three blades of wind turbine, which can avoid resonance phenomenon and meet the precision requirement for engineering application. The laws of acceleration and strain response along the wind turbine under ordinary wind load are obtained by installing acceleration sensor and strain gauge along the wind turbine. We found that the acceleration at the wind turbine top increases 10 times than that at the bottom. The acceleration influenced by tide is 1.14 times than that with no tide. The strain produced maximum value at the opening place of wind turbine and near the top, it should be paid attention in the engineering design.
Perinatal Outcome in Women with Hypertensive Disorders of Pregnancy in Rural Tertiary Center of Northern India: A Retrospective Cohort Study”
Authors: Kumar Naina , Yadav Ashu 
Published: October 2019

Background:
Hypertensive disorder of pregnancy is associated with adverse maternal,
perinatal outcome.

Objective:
To know the perinatal outcome in women with hypertensive disorders of pregnancy.

Methods:
Present retrospective cohort study was conducted in the Obstetrics and Gynecology department
of the rural tertiary center of Northern India over one year (January-December 2018) on
205 antenatal women with hypertensive disorders of pregnancy at gestation ≥28 weeks. All the participants
on the basis of diagnosis were divided into four groups: Group 1 Gestational hypertension;
Group 2 Pre-eclampsia; Group 3 Eclampsia and Group 4 with Chronic Hypertension. Demographic
features, gestational age, the onset of labor, mode of delivery and perinatal outcome including
birthweight, Apgar scores, morbidity and mortality were recorded and compared between four
groups. Statistical analysis was done using software SPSS 22.0. version.

Results:
Of 205 participants, 93 had Gestational Hypertension, 68 Pre-eclampsia; 36 Eclampsia, 06
Chronic Hypertension. The mean age of presentation was 24.96±3.535 years. Average gestation at
birth for group 1 was 37.91±2.38 weeks, group 2: 36.50±3.312 weeks, group 3: 34.44±4.062 weeks
and group 4: 37.97±1.524 weeks. The majority of participants had induced labor especially in preeclampsia
and eclampsia groups with a spontaneous vaginal delivery as the most common mode. 1
and 5-minute Apgar scores, birth weight were lower in eclampsia and pre-eclampsia women. Severe
disease was associated with the adverse perinatal outcome with maximum neonatal morbidity
and mortality in eclampsia and pre-eclampsia group.

Conclusion:
Hence, hypertensive disorder of pregnancy was associated with adverse perinatal outcome,
especially in women with severe disease (Eclampsia and Pre-eclampsia).
Intra-Operative 3-Dimensional Imaging (O-arm) in Foot and Ankle Trauma Surgery: Report of 2 Cases and Review of the Literature
Authors: Jeyaseelan L. , Malagelada F. , Parker L. , Panagopoulos A. , Heidari N. , Vris A. 
Published: October 2019

Background:
Intraoperative two-dimensional (2D) fluoroscopy is the standard imaging modality available to orthopaedic surgeons worldwide. It is well-accepted, however, multiplanar 3 dimensional (3D) CT scanning is superior to 2D imaging for visualising joint surfaces and is now a fundamental feature of the pre-operative planning of intra-articular fractures.

Objective:
We present two cases in which the use of 3D intraoperative imaging and the O-arm® (Medtronic, Minneapolis, USA) led to immediate intraoperative revision to optimise fixation and articular congruity. A review of the current literature is also provided.

Methods:
During the trial period of the O-arm at our major trauma centre, intra-operative imaging was used in the lower limb trauma setting. The O-arm was used intra-operatively in a comminuted pilon fracture and a displaced talus fracture. We recorded all the intra-operative events, including quality of reduction, implant positioning and operation time. Each patient was followed-up for 12 months post-operation and was finally assessed with x-rays and the AOFAS score.

Results:
In both the cases, either fracture reduction or the implant position/usage that was observed with 2D fluoroscopy was revised following a 3D intra-operative scan. No postoperative complications were noted and the healing process was uneventful. X-rays at the final follow-up were excellent and acceptable for the talus and pilon fracture, respectively, with corresponding clinical results and AOFAS score.

Conclusion:
Although frequently used in spinal surgery, to the best of our knowledge, the use of intra-operative 3D techniques in lower limb trauma is sparse and sporadically reported. We present our cases in which the most current innovative imaging techniques influenced intra-operative outcomes without compromising patient safety. We feel that this is a real example of how innovation can positively influence patient care.
Anatomical and Clinical Rationale for Posterolateral Transfibular Approach for Internal Fixation of the Posterolateral Column of the Tibial Plateau
Authors: Kochish A. Yu. , Kislitsyn M. A. , Belen’kii I. G. , Mayorov B. A. , Starchik D. A. 
Published: October 2019

Purpose of the study — to provide an anatomical rationale and evaluate the clinical application of posterolateral surgical approach with osteotomy of the fibular head for internal fixation of the posterior aspect of the lateral tibial condyle. Material and Methods. Anatomical topography research was performed on 14 lower limbs of 8 fresh cadavers. In the first series of research L-shaped plate was fixed on the posterolateral surface of lateral tibial condyle from the examined approach, then preparation was performed and measuring of distances from various parts of the plates to the common peroneal nerve and anterior tibial artery. In the second series the authors prepared histological topograms by transverse sectioning of plastinated specimens from the knee joint area after implantation of L-shaped buttress plates. Prospective observation clinical study included 20 patients who underwent internal fixation with L-shaped buttress plate from the examined approach for fracture of the posterolateral column of the tibial plateau, type 41В by AO classification. KSS and Lysholm scales were used to evaluate treatment outcomes at days 7–10 and in 1, 3, 6 and 9 months postoperatively. Data of the anatomical and clinical research was compared. Results. Compliance with the technique of posterolateral transfibular surgical approach allows to avoid risk of injury to the common peroneal nerve and anterior tibial arthery which on the specimen were always located safely away from implanted plates. All 20 clinical cases demonstrated good visualization of bone fragments and articular surface of the tibial plateau which ensured reliable reduction and fixation by L-shaped buttress plate. KSS excellent and good outcome scores amounted to 50% and 45%, respectively, while satisfactory score was reported in 5% of cases; Lysholm scale demonstrated 55% of excellent outcomes, 45% of good outcomes, and 5% of satisfactory outcomes. Safety of the approach was verified: no injuries to large blood vessels or iatrogenic neuropathies were reported as well as no large hematomas or infectious complications of the surgical wound in early postoperative period. Conclusion. Results of the present study proved the feasibility and safety of the posterolateral transfibular surgical approach for internal fixation procedures in patients with intraarticular fractures of posterolateral column of the tibial plateau.
Mid-term Outcomes of Using Custom-Made Implants for Revision Hip Arthroplasty
Authors: Kovalenko A. N. , Dzhavadov A. A. , Shubnyakov I. I. , Bilyk S. S. , Denisov A. O. , Cherkasov M. A. , Midaev A. I. , Tikhilov R. M. 
Published: October 2019

Introduction. The matter of the replacement of acetabular defects is becoming increasingly relevant today. In their clinic the authors used custom-made implants with trabecular coating for replacement of defects in the acetabulum where and when it was necessary to ensure extended fixation of the component. Purpose — to evaluate short-term clinical and functional outcomes, osteointegration of porous coated custom-made implants, the overall survival of structural components and to identify the causes of failures and complications. Materials and Methods. During the study the authors interviewed and evaluated radiographs of 48 patients operated from October 2015 to June 2018. The patients were interviewed before and after the surgery using the Oxford hip joint scale, quality of life EQ-5D and visual analogue pain scale. Radiographs were evaluated for a period of at least 12 months for the signs of osteointegration. Results. The average OHS scores increased from 14.9 (±7) to 37.6 (±7) (p0.01). Quality of life according to the EQ-5D index increased from 0.2 (±0.2) to 0.7 (±0.2) (p0.01). The average value by general health scales: before operations — 49 (±17) and 73 (±18) scores after surgeries (p0.01). The average VAS pain score decreased from 73 (±10) to 19 (±19) points (p0.01). Osteointegration was observed in 98 percent of cases. Migration of the implant with fracture of a flange was observed in one case. Conclusions. In the short-term follow up the use of custom-made implants significantly improves hip joint function and the patients’ life quality. Custom-made implants enable primary reliable fixation in case of complex acetabular defects. High rate of osteointegration is observed for custom-made implants with porous coating within at least 12 months. Longer follow-up is needed to evaluate long-term results.
Is the Any Clinical Importance for Separation Congenitally Dislocated Hip in Adults into Types C1 and C2 by Hartofilakidis?
Authors: Tikhilov R. M. , Shubnyakov I. I. , Denisov A. O. , Pliev D. G. , Shubnyakov M. I. , Vahramyan A. G. , Avdeev A. I. 
Published: October 2019

The main questions of the study: 1) is there any difference in anatomical features between subtypes C1 and C2 of high hip dislocation by Hartofolakidis classification; 2) are the conditions for performing the THA different and what are the surgical decisions; 3) what are the THA results in different groups? Materials and Methods. In a single center study the authors retrospectively evaluated the outcomes of 561 THAs performed in 349 patients with a high hip dislocation including 32 men (9.2%) and 317 women (90.8%) with the follow up from 12 to 188 months (average 69,4 months). In 326 cases (58.1%) the dislocation was assessed as type C1, and in 235 cases (41.9%) — as type C2. The average age of the patients at the time of surgery was 47.6 (19 to 74) years, for men — 39.1 years and 48.1 years for women. Results. Paavilainen shortening osteotomy was performed in 100% of patients with type C2 and only in 50.6% of patients with type C1, p0.001. The cup was implanted into the true acetabulum cavity in 99.1% of cases with type C2, and for type C1 only in 69.0% of cases, p0.001. Lateral under-coverage of the cup in patients with type C2 required supplementing by femoral head autograft only in three cases, and for type C1 — in 18 patients, p = 0.009. In the group of C2, the mean length of the osteotomized fragment of the proximal femur was 78.6 mm compared to 62.5 mm in patients with type C1. This provided a better contact area between the greater trochanter and the femur and in 92.8% of cases fixation was done by cerclage wires and two screws. In the group of patients with type C1, this option was feasible only in 60.0% of cases. Odds ratio (OR) for fixation of the greater trochanter by a special plate for primary indications in patients with type C1 were 10 367, p = 0.008. Harris Hip score improved averaged from 39.5 points to 83.6, without statistically significant differences between groups of C1 and C2. Early complications included 9 dislocations (1.6%), 8 cases of femoral nerve neuropathy (1.4%) and 3 early infections (0.5%). No cases of sciatic nerve paresis were observed. Non-union of the greater trochanter was observed with almost equal frequency in patients with C1 and C2 types, and revision fixation was needed in 27 patients (6.8%). Revision arthroplasty was performed in 22 cases (3.9%) due to 4 infections, 2 aseptic loosening of the stem, 11 aseptic loosening of the acetabular component and 5 recurrent dislocations. Conclusion. The group of patients with high hip dislocation is very heterogenic in terms of severity of anatomical changes and demands different surgical tactics. Hartofolakidis classification helps the surgeon to select the best type of the surgical procedure, minimize the mistakes and predict treatment outcomes.
Conversational Agents in the Treatment of Mental Health Problems: Mixed-Method Systematic Review
Authors: Gaffney Hannah , Mansell Warren , Tai Sara 
Published: October 2019

Background
The use of conversational agent interventions (including chatbots and robots) in mental health is growing at a fast pace. Recent existing reviews have focused exclusively on a subset of embodied conversational agent interventions despite other modalities aiming to achieve the common goal of improved mental health.

Objective
This study aimed to review the use of conversational agent interventions in the treatment of mental health problems.

Methods
We performed a systematic search using relevant databases (MEDLINE, EMBASE, PsycINFO, Web of Science, and Cochrane library). Studies that reported on an autonomous conversational agent that simulated conversation and reported on a mental health outcome were included.

Results
A total of 13 studies were included in the review. Among them, 4 full-scale randomized controlled trials (RCTs) were included. The rest were feasibility, pilot RCTs and quasi-experimental studies. Interventions were diverse in design and targeted a range of mental health problems using a wide variety of therapeutic orientations. All included studies reported reductions in psychological distress postintervention. Furthermore, 5 controlled studies demonstrated significant reductions in psychological distress compared with inactive control groups. In addition, 3 controlled studies comparing interventions with active control groups failed to demonstrate superior effects. Broader utility in promoting well-being in nonclinical populations was unclear.

Conclusions
The efficacy and acceptability of conversational agent interventions for mental health problems are promising. However, a more robust experimental design is required to demonstrate efficacy and efficiency. A focus on streamlining interventions, demonstrating equivalence to other treatment modalities, and elucidating mechanisms of action has the potential to increase acceptance by users and clinicians and maximize reach.
EFFECT OF LEVETIRACETAM ON HEALING OF EXCISION AND BURN WOUND MODELS IN WISTAR RATS
Authors: KH RASHID HUBA , PATIL NAVIN , O BALAJI , TILAK AMOD 
Published: October 2019

Objective: Levetiracetam (LEV) at lower doses (50 and 100 μg/ml) has demonstrated antioxidant effect as per literature evidence. Hence, the aim of current study was to evaluate the action of LEV on wound healing with regard to its antioxidant properties.
Methods: A total of 30 adult rats of both the sexes weighing 150–250 g were randomly divided into five groups of six rats each. Excision and burn models were used. The five groups are as follows: Group 1: Normal saline, Group 2: Povidone-iodine, Group 3: Silver sulfadiazine, Group 4: LEV 50 mg/kg, and Group 5: LEV 100 mg/kg. Group 2 served as a standard control for excision wound model and Group 3 as a standard for burn wound model. LEV was given orally and all other drugs were given topically. The rate of wound contracture and period of epithelization were calculated from the initial wound size for all rats.
Results: In both the models, the rats treated with standard drug (povidone-iodine/silver sulfadiazine) and LEV showed faster rates of wound contraction, period of epithelization, and better antioxidant effect as compared to the control and the difference seen was statistically significant (p<0.001). However, the rats treated with povidone-iodine/silver sulfadiazine showed faster rates of wound contraction and period of epithelization as compared to the rats treated with LEV and the difference was statistically significant (p<0.05).
Conclusion: The results of the study show that oral application of LEV enhanced the wound strength and accelerated healing of incision and burn wounds in rats. Further clinical trials can be done to prove the effect of LEV as an agent for wound healing.