bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colliding winds in and around the stellar group IRS 13E at the galactic centre
Authors: Wang Q Daniel , Li Jun , Russell Christopher M P , Cuadra Jorge 
Published: December 2019

ABSTRACT
IRS 13E is an enigmatic compact group of massive stars located in projection only 3.6 arcsec away from Sgr A*. This group has been suggested to be bounded by an intermediate-mass black hole (IMBH). We present a multiwavelength study of the group and its interplay with the environment. Based on Chandra observations, we find the X-ray spectrum of IRS 13E can be well characterized by an optically thin thermal plasma. The emission peaks between two strongly mass-losing Wolf–Rayet stars of the group. These properties can be reasonably well reproduced by simulated colliding winds of these two stars. However, this scenario underpredicts the X-ray intensity in outer regions. The residual emission likely results from the ram-pressure confinement of the IRS 13E group wind by the ambient medium and is apparently associated with a shell-like warm gas structure seen in Pa α and in ALMA observations. These latter observations also show strongly peaked thermal emission with unusually large velocity spread between the two stars. These results indicate that the group is colliding with the bar of the dense cool gas mini-spiral around Sgr A*. The extended X-ray morphology of IRS 13E and its association with the bar further suggest that the group is physically much farther away than the projected distance from Sgr A*. The presence of an IMBH, while favourable to keep the stars bound together, is not necessary to explain the observed stellar and gas properties of IRS 13E.
The Hubble Space Telescope UV Legacy Survey of Galactic globular clusters – XXI. Binaries among multiple stellar populations
Authors: Milone A P , Vesperini E , Marino A F , Hong J , van der Marel R , Anderson J , Renzini A , Cordoni G , Bedin L R , Bellini A , Brown T M , D’Antona F , Lagioia E P , Libralato M , Nardiello D , Piotto G , Tailo M , Cool A , Salaris M , Sarajedini A 
Published: December 2019

Abstract
A number of scenarios for the formation of multiple populations in globular clusters (GCs) predict that second generation (2G) stars form in a compact and dense subsystem embedded in a more extended first-generation (1G) system. If these scenarios are accurate, a consequence of the denser 2G formation environment is that 2G binaries should be more significantly affected by stellar interactions and disrupted at a larger rate than 1G binaries. The fractions and properties of binary stars can thus provide a dynamical fingerprint of the formation epoch of multiple-population GCs and their subsequent dynamical evolution. We investigate the connection between binaries and multiple populations in five GCs, NGC 288, NGC 6121 (M 4), NGC 6352, NGC 6362, and NGC 6838 (M 71). To do this, we introduce a new method based on the comparison of Hubble Space Telescope observations of binaries in the F275W, F336W, F438W, F606W, and F814W filters with a large number of simulated binaries. In the inner regions probed by our data, we do not find large differences between the local 1G and the 2G binary incidences in four of the studied clusters, the only exception being M 4 where the 1G binary incidence is about three times larger than the 2G incidence. The results found are in general agreement with the results of simulations predicting significant differences in the global 1G and 2G incidences and in the local values in the clusters’ outer regions but similar incidences in the inner regions. The significant difference found in M 4 is consistent with simulations with a larger fraction of wider binaries. Our analysis also provides the first evidence of mixed (1G–2G) binaries, a population predicted by numerical simulations to form in a cluster’s inner regions as a result of stellar encounters during which one component of a binary is replaced by a star of a different population.
Firm Response to Competitive Shocks: Evidence from China’s Minimum Wage Policy
Authors: Hau Harald , Huang Yi , Wang Gewei 
Published: December 2019

Abstract
The large regional variation in minimum wage levels during the period 2002–8 in China implies that Chinese manufacturing firms experienced competitive shocks as a function of firm location and their low-wage employment share. We find that minimum wage hikes accelerate the input substitution from labour to capital, reduce employment growth and accelerate total factor productivity growth—particularly among the less productive firms under private Chinese or foreign ownership, but not among state-owned enterprises. The heterogeneous firm response to labour cost shocks can be explained by differences in management practices and suggests that management quality and competitive pressure are complementary.
The Segregation Premium: How Gender Shapes the Symbolic Valuation Process of Occupational Prestige Judgments
Authors: Valentino Lauren 
Published: December 2019

AbstractSymbolic valuation is an important but overlooked aspect of gendered processes of inequality in the occupation structure. Prior work has largely focused on the material valuation of gendered work, such as how much predominantly-female versus predominantly-male occupations pay. Less research has examined the symbolic valuation of work, such as how prestigious predominantly-female versus predominantly-male occupations are. What research has examined this question has remained inconclusive at best. Drawing on insights into and techniques from the sociology of culture and cognition, this study examines the role of an occupation’s gender composition in how Americans judge the prestige of jobs, testing key predictions from theories of gender and status. Using 2012 General Social Survey and federal occupation-level data, it finds evidence for a segregation premium: people view gender-segregated occupations as the most symbolically valuable jobs. Both men and women reward gender-segregated occupations with symbolic value, although there is evidence of a gendered in-group bias in which women in particular see women’s work as more prestigious, while men see men’s work as more prestigious.
Diabetes-associated cardiac autonomic neuropathy
Authors: Wooton Angela K. , Melchior Lynne 
Published: December 2019

Abstract:
Cardiac autonomic neuropathy (CAN) is an underdiagnosed cardiovascular complication associated with diabetes. NPs are in a pivotal position to screen patients for CAN. As the incidence of diabetes increases in an aging population, NPs can help prevent complications associated with diabetes and CAN.
Targeting BRAF and MEK inhibitors in melanoma in the metastatic, neoadjuvant and adjuvant setting
Authors: Tétu Pauline , Baroudjian Barouyr , Lebbe Céleste 
Published: December 2019

Purpose of review
Better understanding of the biology of BRAF-mutated melanoma has led to the development of highly effective therapy, BRAF and MEK inhibitors, targeting abnormally activated protein kinases for patient with BRAF-mutated melanoma. The purpose of this article was to review the recent published data on BRAF and MEK inhibitors in melanoma in the metastatic, adjuvant and neoadjuvant setting to facilitate the management of melanoma patients in clinical practice.

Recent findings
The spectacular outcomes of targeted therapy in advanced melanoma patients have led to their development in the adjuvant setting with substantial improvements in recurrence-free and overall survival. The neoadjuvant strategy is already used in many cancers to decrease tumor load, improve resectability and prevent relapse. Targeted therapy in the neoadjuvant setting is a therapeutic approach being explored in subsequent studies.

Summary
We hope that this review will help clinicians to manage melanoma patients in routine practice.
Intrathoracic Breast Transposition: A New Method in the Treatment of Bronchopleural Fistula and Empyema
Authors: de Weerd Louis , Endresen Petter Cappelen , Numan Anmar Tabit , Weum Sven 
Published: December 2019

Summary:
A bronchopleural fistula (BF) is a life-threatening complication. Optimal management of a BF is still debated although surgery remains the preferred treatment. Usually, the fistula is a result of inadequate healing at the bronchial stump after pneumonectomy. Successful closure of a BF after pneumonectomy depends on evacuation of empyema, coverage of the suture line after fistula closure with vascularized tissue, and obliteration of the residual pleural cavity. Extrathoracic muscles and omentum are the first choice for intrathoracal transposition. We report a unique case of a cachectic female patient with a BF from the left main stem bronchus complicated with empyema following right-sided pneumonectomy. Previous surgeries excluded the use of extrathoracic muscles or only omentum. The BF could not be closed with sutures. Using a parachute technique, omentum was sutured into the fistula opening resulting in a tension-free fistula closure. A well-vascularized breast was transposed into the residual pleural cavity to obliterate dead space and to support the omentoplasty, so it would be able to withstand changes in intrathoracic pressure. The postoperative course was uneventful. Tension-free closure of a BF can be obtained by suturing well-vascularized tissue into the fistula opening using a parachute technique. Intrathoracic breast transposition could be a new option in the treatment of a BF and associated empyema in a female patient. In selected patients, a large breast can obliterate the dead space after pneumonectomy and support the omentoplasty.
Mechanical circulatory support in cardiogenic shock
Authors: Frost Andrew , Haddad Haissam , Shavadia Jay 
Published: December 2019

Purpose of review
Cardiogenic shock remains a complex clinical syndrome with high morbidity and mortality. The purpose of this article is to review important landmark trials as well as the relevant recent literature for percutaneous mechanical circulatory support following acute myocardial infarction.

Recent findings
The sole use of intraaortic balloon pumps for cardiogenic shock following acute myocardial infarction continues to be questioned with downgrading of its recommendation in recent years, there however may remain a role in patients with mechanical complications of their myocardial infarction. The combined use of extracorporeal circulatory support and a ventricular unloading device appears to be promising with increasing data supporting this strategy.

Summary
Given the complex and heterogeneous nature of cardiogenic shock there remains somewhat limited robust data to guide clinical practice. Ongoing research is needed to help guide improvements in patient outcomes.
CHOROIDAL NEOVASCULAR MEMBRANE AFTER FINE-NEEDLE ASPIRATION BIOPSY OF VITREORETINAL LYMPHOMA
Authors: Mashayekhi Arman , Mazloumi Mehdi , Shields Carol L. , Shields Jerry A. 
Published: December 2019

Purpose:
To report development of choroidal neovascular membrane at the site of diagnostic transvitreal fine-needle aspiration biopsy of subretinal pigment epithelial infiltrates in an eye with vitreoretinal lymphoma.

Methods:
Case report. A 75-year-old white woman with 14-month history of bilateral vitritis.

Results:
Examination showed vitreous infiltration in both eyes and yellow-white subretinal pigment epithelial infiltrates temporally in the left eye. Visual acuity was 20/400 in both eyes. Transvitreal fine-needle aspiration biopsy of subretinal pigment epithelial infiltrate in the left eye using a long 27-gauge needle attached to a 10-mL syringe revealed large B-cell lymphoma. Treatment was initiated with monthly intravitreal injections of melphalan (10 μg/0.05 mL) to both eyes. One month after first injection, visual acuity in the left eye had decreased to hand motion, and new ill-defined patches of retinal whitening were noticeable in the temporal macular area. Intravenous fluorescein angiography and optical coherence tomography angiography showed large choroidal neovascular membrane temporally at the site of previous fine-needle aspiration biopsy. Four monthly injections of intravitreal bevacizumab (1.25 mg/0.05 mL) resulted in complete regression of choroidal neovascular membrane with improvement of visual acuity to 20/100 in the left eye.

Conclusion:
This case demonstrates the rare development of choroidal neovascular membrane at the site of diagnostic transvitreal fine-needle aspiration biopsy of subretinal pigment epithelial infiltrates in an eye with vitreoretinal lymphoma.
Contemporary management of refractory pediatric glaucoma
Authors: Malik Rizwan , AlDarrab Abdulrahman , Edward Deepak P. 
Published: December 2019

Purpose of review
The management of pediatric glaucoma poses a unique challenge in terms of maintaining lifelong vision and combating an aggressive scarring response from surgery. Contemporary literature regarding the surgical management of children with pediatric glaucoma who fail, or are at a high risk of failure, from conventional surgery is limited. The aim of this review is to highlight recent developments in relation to the current opinion regarding the management of children with refractory pediatric glaucoma.

Recent findings
Some studies have reported impressive success rates with circumferential trabeculotomy, even in eyes with previous failed surgery. Early results of deep sclerectomy in populations which may not respond well to conventional angle surgery are encouraging but data is limited for the pediatric age group. In compliant patients in whom multiple postoperative examinations under anesthesia are possible, trabeculectomy remains an effective procedure. Multiple recent studies have demonstrated that glaucoma drainage device (GDD) surgery is associated with 5-year success rates of over 70% in primary childhood glaucomas.

Summary
Glaucoma drainage device surgery is likely to remain a mainstay of surgical management for refractory glaucoma in older children. More prospective data are needed on the success of circumferential trabeculotomy, deep sclerectomy and micropulse laser in pediatric eyes with previous failed surgery.

Video abstract

http://links.lww.com/COOP/A34.
Epigenetic upregulation of acid-sensing ion channel 1 contributes to gastric hypersensitivity in adult offspring rats with prenatal maternal stress
Authors: Wang Hong-Jun , Xu Xue , Zhang Ping-An , Li Meng , Zhou You-Lang , Xu Yu-Cheng , Jiang Xing-Hong , Xu Guang-Yin 
Published: December 2019

Abstract
Functional dyspepsia is a common functional gastrointestinal disorder. Gastric hypersensitivity (GHS) is a hallmark of this disorder, but the cellular mechanisms remain largely unknown. Stressors during gestational period could have effects on the offspring's tissue structure and function, which may predispose to gastrointestinal diseases. The aim of this study was to test whether prenatal maternal stress (PMS) induces GHS and to investigate role of acid-sensing ion channel (ASIC)/nuclear factor-κB (NF-κB) signaling by examining Asic1 methylation status in adult offspring rats. Gastric hypersensitivity in response to gastric distension was examined by electromyography recordings. Changes in neuronal excitability were determined by whole-cell patch-clamp recording techniques. Demethylation of CpG islands of Asic1 was determined by methylation-specific PCR and bisulfite sequencing assay. Prenatal maternal stress produced GHS in adult offspring rats. Treatment with amiloride, an inhibitor of ASICs, significantly attenuated GHS and reversed hyperexcitability of gastric-specific dorsal root ganglion (DRG) neurons labeled by the dye DiI. Expression of ASIC1 and NF-κBp65 was markedly enhanced in T7 to T10 DRGs. Furthermore, PMS led to a significant demethylation of CpG islands in the Asic1 promoter. A chromatin immunoprecipitation assay showed that PMS also enhanced the ability of NF-κBp65 to bind the promoter of Asic1 gene. Blockade of NF-κB using lentiviral-p65shRNA reversed upregulation of ASIC1 expression, GHS, and the hyperexcitability of DRG neurons. These data suggest that upregulation of ASIC1 expression is attributed to Asic1 promoter DNA demethylation and NF-κB activation, and that the enhanced interaction of the Asic1 and NF-κBp65 contributes to GHS induced by PMS.
Informal caring for back pain: overlooked costs of back pain and projections to 2030
Authors: Schofield Deborah , Zeppel Melanie J.B. , Tanton Robert , Veerman Jacob , Kelly Simon , Passey Megan E. , Shrestha Rupendra N. 
Published: December 2019

Abstract
This study models the economic costs of informal caring for people with back pain, using a microsimulation model, Care&WorkMOD, from 2015 to 2030. Care&WorkMOD was based on 3 national Australian Surveys of Disability, Ageing and Carers (2003, 2009, 2012) data sets for individuals aged 15 to 64 years. Estimated national income loss due to caring for people with back pain was AU$258 million in 2015, increasing to $398 million in 2030 (54% increase). Lost income tax revenue to the Australian government due to informal care of people with back pain was estimated to be AU$78 million in 2015, increasing to AU$118 million in 2030 (50% increase), and additional welfare payments were estimated to rise from $132 million in 2015 to AU$180 in 2030 (36% increase). Larger growth in lost income, compared with the increase in welfare payments, means that there would be an increasing income gap between those out of the labour force providing informal care and noncarers who are in the labour force, leading to increased inequality. Informal carers are defined as providers of informal, unpaid assistance to someone with a health condition, for at least 6 months. Informal carers of people with back pain who are out of the labour force incur substantial economic costs. Furthermore, back pain is a large economic burden on national governments. Policies addressing back pain prevention and treatment, and supporting carers, may offset government welfare expenditure, while improving the socioeconomic well-being of carers and patients.
Intrahepatic biliary strictures after liver transplantation are morphologically similar to primary sclerosing cholangitis but immunologically distinct
Authors: Zhou Taotao , Bartelheimer Katja , Ruping Fabian , Rupp Christian , Sauer Peter , Koschny Ronald , Mehrabi Arianeb , Mieth Markus , von Haken Rebecca , Weiss Karl Heinz , Gotthardt Daniel Nils , Rauber Conrad 
Published: December 2019

Objective
Biliary strictures are an important cause of morbidity and mortality in primary hepatic disease and after liver transplantation (LT). We aimed to characterize inflammatory cytokines in biliary fluids in biliary strictures to investigate their immunological origin.

Methods
We conducted a retrospective study on 72 patients with strictures after LT, eight patients with primary sclerosing cholangitis (PSC) and 15 patients with secondary sclerosing cholangitis (SSC). We measured cytokines interleukin (IL)-2, -4, -6, -10, -17, monocyte chemoattractant protein (MCP)-1, fibroblast growth factor (FGF)-2 and interferon (IFN)-γ as well as biochemical components such as protein and phospholipids in biliary fluid obtained from endoscopic retrograde cholangiography (ERC). Cell viability assays were performed on human cholangiocytes (H69) after being treated with IL-6, IL-4 and IFN-γ.

Results
Bile of patients with diffuse strictures after LT or due to SSC showed low values of all measured cytokines except for IL-6 levels, which were largely elevated in patients with diffuse strictures after LT. Patients high in biliary IL-6 showed an increase in profibrotic markers FGF-2 and MCP-1. In contrast, PSC bile was dominated by a Th1/Th17 profile with elevated IL-2, IL-17 and IFN-γ. In LT patients with biliary strictures, biliary IL-6 negatively predicted retransplantation-free survival after ERC.

Conclusion
PSC patients showed a biliary Th1/Th17 cytokine profile, while SSC and diffuse strictures showed low values of cytokines except IL-6. In diffuse intrahepatic strictures after LT, biliary IL-6 is strongly associated with retransplantation-free survival after ERC.
Qualitative and quantitative reproducibility of [18]fluoromethycholine PET/computed tomography in prostate cancer
Authors: Pinto-Leite Thomas , Tixier Florent , Upadhaya Taman , Gallais Christelle , Perdrisot Remy , Cheze Le Rest Catherine 
Published: December 2019

Background
Recurrence occurs in more than 50% of prostate cancer. To be effective, treatments require precise localization of tumor cells. [18F]fluoromethylcholine ([18F]FCH) PET/computed tomography (CT) is currently used to restage disease in cases of biochemical relapse. To be used for therapy response as has been suggested, repeatability limits of PET derived indices need to be established.

Objective
The aim of our study was to prospectively assess the qualitative and quantitative reproducibility [18F]FCH PET/CT in prostate cancer.

Methods
Patients with histologically proven prostate cancer referred for initial staging or restaging were prospectively included. All patients underwent two [18F]FCH PET/CTs in the same conditions within a maximum of 3 weeks’ time. We studied the repeatability of the visual report and the repeatability of SUVmax and its evolution over the acquisition time in lesions, liver and vascular background. Statistical analysis was performed using the Bland–Altman approach.

Results
Twenty-one patients were included. Reporting repeatability was excellent with 97.8% of concordance. Mean repeatability of SUVmax considering all times and all lesions was 2.2% ± 20. Evolution of SUVmax was unpredictable, either increasing or decreasing over the acquisition time, both for lesions and for physiological activity.

Conclusion
Our study demonstrated that visual report of [18F]FCH PET/CT was very reproducible and that the repeatability limits of SUVmax was similar to those of other PET radiotracers. An SUVmax difference of more than 40% should be considered as representing a treatment response effect. Change of SUVmax during the acquisition time varied and should not be considered as an interpretation criterion.
Immune contexture of cholangiocarcinoma
Authors: Paillet Juliette , Kroemer Guido , Pol Jonathan G. 
Published: December 2019

Purpose of review
Considering the failure of standard treatments (i.e. surgery, radiotherapy, chemotherapy) in treating cholangiocarcinoma (CCA), introduction of alternative interventions is urgently needed. During the past 2 decades, discoveries of the mechanisms of cancer immunosurveillance and tumor immune evasion have precipitated the emergence and clinical approval of immunotherapies in multiple malignant indications. Interest in their introduction for the care of CCA is recent and several immunotherapeutic approaches are undergoing a clinical evaluation. Undoubtedly, their efficient application, as monotherapy or in combination regimens, will rely on a deeper understanding of CCA immune contexture.

Recent findings
CCA cells appeared very potent in recruiting protumorigenic cells and shaping an immunosuppressive microenvironment. Elevated densities of several immune cells with immunoinhibitory activities within the malignant bed have been associated with poor prognosis in patients. Particularly, macrophages and neutrophils (especially in their alternatively activated phenotype) were pointed out for their role in cancer progression. Dendritic cells were described as ineffective in priming CCA-specific T-cell responses.

Summary
Quantitative and qualitative assessment of the innate and adaptive immune compartments of the CCA immune contexture, as well as their prognostic value, will benefit to the development of improved immunotherapeutic strategies.