bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Validation of an Open-Source Grading Tool for Outcome Assessment in Limbal Stem Cell Treatment
Authors: Behaegel Joséphine , Consejo Alejandra , Wouters Kristien , Koppen Carina , De Cock Joost , Ní Dhubhghaill Sorcha 
Published: February 2020

Purpose:
To design a grading system and validate an open-source tool to improve objective quantification and follow-up of limbal stem cell deficiency (LSCD) after treatment.

Methods:
A custom-made web-based grading system was developed for grading stem cell deficient eyes, termed the “Vascularisation, Haze, and Integrity” tool. For validation purposes, 60 corneal slit-lamp images of 30 limbal stem cell deficient eyes were graded by 3 groups of examiners: 3 corneal specialists (group A), 3 ophthalmologists with an expertise other than cornea (group B), and 3 nonclinicians (group C). The intragrader and intergrader agreement was evaluated using Fleiss weighted kappa coefficients and concurrent assessment of interrater and intrarater reliability (IRR) coefficients.

Results:
The overall intergrader agreement was 0.78, 0.61, and 0.42 for superficial corneal vascularization, corneal haze, and epithelial integrity, respectively. All groups had good agreement for the vascularization parameter with the highest intergrader reliability in group A (IRR = 0.80) and the lowest in group C (IRR = 0.72). When assessing “haze,” there was good agreement in groups A (IRR = 0.75) and B (IRR = 0.76) but low agreement in group C (IRR = 0.37).

Conclusions:
We report the development and evaluation of a novel method for grading results of limbal stem cell deficient eyes after treatment and provide this system as a free, open-source online tool. The grading tool offers an easy and standardized way of assessing the corneal surface in patients with LSCD, enables evaluation of progression over time, reduces assessment bias, and—if adopted universally—will harmonize outcome being reported between groups.
Diagnosis and Management of Acute Thrombosis in Venous Dominant Orbital Venolymphatic Malformations
Authors: Grob Seanna R. , Bokman Christine , Nathe Connor , Rootman Daniel B. , Feldman Kenneth A. 
Published: February 2020

Purpose:
To report the characteristic clinical and imaging findings in a series of patients with thrombosed orbital venolymphatic malformations.

Methods:
Patients affected by acute thrombosis of an orbital venolymphatic malformation were reviewed. Clinical findings including symptoms and signs of presentation, characteristic imaging features, and clinical course are presented.

Results:
Ten patients were identified. The mean age at presentation was 56 years. All patients presented with acute pain or pressure sensation, with the most common additional presenting symptoms being proptosis (6/10) and diplopia (5/10). CT imaging typically demonstrated a nonspecific orbital mass. Nine patients underwent MRI which revealed a soft tissue mass with peripheral rim enhancement and a central, typically T2 hypointense, core. Seven out of 10 patients were observed and had improvement in symptoms and signs without surgical intervention. Two patients underwent surgical intervention for intractable pain.

Conclusion:
Patients with thrombosis of a venolymphatic malformation often present with acute pain, proptosis, and diplopia. Characteristic MRI findings of a peripheral rim enhancing mass with a T2 hypointense core can be noted. Careful observation is a reasonable management option for cases without visual compromise or intractable pain.
Optic capture after intrascleral haptic fixation: February consultation #1
Authors: Fram Nicole 
Published: February 2020

A 45-year-old man was originally referred for management of spontaneous subluxation of the inferior haptic of a 3-piece intraocular lens (IOL) into the anterior chamber of the right eye (Figure 1). He had a significant past ocular history of laser–assisted laser in situ keratomileusis (LASIK) in both eyes, pars plana vitrectomy/scleral buckle for retinal detachment repair in the right eye, and pseudophakia in both eyes. The corrected distance visual acuity was 20/200 in the right eye and 20/20 in the left eye. Of note, he had severe iridodonesis, a 2+ pigmented cell in the anterior chamber without significant pseudophacodonesis and the posterior capsule was intact with striae. The referring physician attempted a refixation surgery that failed, and the patient was ultimately left aphakic.

JOURNAL/jcrs/04.03/02158034-202002000-00026/figure1/v/2023-08-19T002530Z/r/image-tiff

Next, a secondary 3-piece posterior chamber (PC) IOL (CT Lucia 602, Carl Zeiss Meditec AG) was fixated with the Yamane flanged intrascleral haptic fixation technique (ISHF). A surgical peripheral iridotomy (PI) was made with the vitrector to avoid pupillary capture postoperatively.
On postoperative day 1 the patient had a well-centered PC IOL and uncorrected distance visual acuity (UCVA) of 20/30. However, on postoperative day 14 the patient complained of decreased vision as the UCVA dropped to 20/100 and pupillary capture of the optic was noted. In addition, there was a 3+ pigmented cell in the anterior chamber, pigment dusting on the anterior surface of the PC IOL, and an intraocular pressure (IOP) of 32 mm Hg (Figure 2).

JOURNAL/jcrs/04.03/02158034-202002000-00026/figure2/v/2023-08-19T002530Z/r/image-tiff

What additional testing would you consider? How would you manage this patient's problem?
Exploring the neural correlates of touch and pain in women with provoked vestibulodynia
Authors: Sutton Katherine S. , Yessick Lindsey R. , Wild Conor J. , Chamberlain Susan M. , Pukall Caroline F. 
Published: February 2020

Abstract
Group differences in touch and pain thresholds—and their neural correlates—were studied in women with provoked vestibulodynia (PVD; N = 15), a common subtype of vulvodynia (chronic vulvar pain), and pain-free control women (N = 15). Results from quantitative sensory testing and self-report measures indicated that, as compared with control participants, women with PVD exhibited allodynia (ie, pain in response to a normally nonpainful stimulus) and hyperalgesia (ie, an increased response to a normally painful stimulus) at vulvar and nonvulvar sites. In addition, brain imaging analyses demonstrated reduced difference scores between touch and pain in the S2 area in women with PVD compared with control participants, supporting previous findings of allodynia in women with PVD. There were no significant reductions in difference scores between touch and pain for regions related to cognitive and affective processing of painful stimuli. The results of this study contribute important information to the general pain and vulvodynia literatures in elucidating the specific sensorimotor neural mechanisms that underlie hyperalgesia in a chronic pain population. These results have implications for differentiating neural processing of touch and pain for women with and without PVD. Future research should attempt to examine alterations related to hyperalgesia in commonly comorbid conditions of PVD.
Bodily changes and sensory sensitivity in complex regional pain syndrome and fibromyalgia
Authors: Ten Brink Antonia F. , Peters Louisa , Kompouli Paraskevi-Ioanna , Jordan Abbie , McCabe Candida S. , Goebel Andreas , Bultitude Janet H. 
Published: February 2020

Abstract
Complex regional pain syndrome (CRPS) and fibromyalgia are chronic pain conditions of unexplained origins. In addition to symptoms in the diagnostic criteria, patients can report changes to vision and other sensations or bodily functions. It is unclear whether these are greater than would be expected due to normal ageing, living with chronic pain generally, or common comorbidities of chronic pain such as depression or anxiety. We administered an on-line survey evaluating the frequencies and types of self-reported somatic symptoms, bodily changes, and sensory sensitivity in respondents with CRPS (n = 390), fibromyalgia (n = 425), and both CRPS and fibromyalgia (“CRPS+fibromyalgia”; n = 88) compared to respondents with other chronic pain conditions (n = 331) and pain-free controls (n = 441). The survey assessed somatic symptoms (Patient Health Questionnaire-15), bodily changes, pain/discomfort/distress triggers, and pain intensifiers. We conducted analysis of covariance's with age, sex, Patient Health Questionnaire-9 (measuring depression), Generalized Anxiety Disorder-7, pain duration in years, hours of pain per day, and number of pain-related medical diagnoses as covariates. After controlling for covariates, respondents with CRPS and/or fibromyalgia reported more somatic symptoms, changes in movement and biological responses, pain/discomfort/distress triggers, and pain intensifiers than pain(-free) control groups. Fibromyalgia specifically related to changes in vision and hearing, urinary/intestinal function, and drinking and eating. Complex regional pain syndrome related to changes in hair, skin, and nails; and infection and healing. The CRPS+fibromyalgia group presented with features of both disorders with minimal additional stressors or symptoms over and above these. Our findings suggest that CRPS and fibromyalgia share underlying pathophysiologies, although specific mechanisms might be different.
Mental Demands at the Workplace—Are Information Load, Time Control, and Exploration Associated With Depressiveness?
Authors: Hussenoeder Felix S. , Conrad Ines , Riedel-Heller Steffi G. , Rodriguez Francisca S. 
Published: February 2020

Objective:
According to self-determination theory, autonomy and competence are two essential basic human needs. It is the aim of this study to show that mental demands at the workplace (WPMDs) that address those basic needs can protect employees against depressiveness.

Methods:
Using a sample of 346 working participants (average age 56.2), we derived three WPMDs (Information Load, Time Control, and Exploration) via principal component analysis. We then analyzed how far they predict depressiveness, and how far this mechanism is mediated by perceived fit between job and person (PJF).

Results:
Time Control and Exploration significantly reduced depressiveness, and the relationship between exploration and depressiveness was mediated by PJF.

Conclusions:
Our results emphasize the importance of addressing basic human needs at the workplace, and the relevance of PJF for employee mental health.
The correlation between intestinal mucosal lesions and hepatic dysfunction in patients without chronic liver disease
Authors: Wu Li-Hao , Chen Mei-Hui , Cai Jie-Yi , Yuan Yu , Wu Li-Quan , Zhou Hui-Min , Li Lan , Wan Kayiu , He Xing-Xiang 
Published: February 2020

Abstract
Patients with cirrhosis are known to develop small bowel mucosal lesions. However, the occurrence of mucosal lesions in patients with abnormal liver function test results in the absence of chronic liver disease has not been fully evaluated. This study aims to examine the association between small bowel endoscopic lesions and liver dysfunction in patients without confirmed chronic liver disease.
Two hundred ninety six consecutive patients who met the selection criteria underwent capsule endoscopy. The severity of the small intestinal mucosal lesions was evaluated quantitatively using the Lewis scoring system, and hepatic dysfunction was evaluated using an algorithm-based combination scoring system with 8 individual serological markers.
Small bowel lesions were observed in 121 patients (40.88%). Hepatic dysfunction was significantly more prevalent in patients with small bowel lesions than in those without lesions (33.1%; 40/121 and 5.7%; 10/175, respectively; P < .001). The mean serum ALT and AST levels were significantly higher in patients with small bowel lesions than in those without lesions (P = .007 and P = .004, respectively). The mean scores for AST to Platelet Ratio Index, Forns Index, S-Index, Fibrosis-4 Index and BARD were significantly higher in patients with small bowel lesions than those without lesions. The Lewis score significantly and positively correlated with the Forns Index (P = .008) and the FIB-4 Index (P = .006).
There is a close correlation between small intestinal mucosal lesions and hepatic dysfunction. The severity of hepatic dysfunction is directly proportional to the severity of the small intestinal mucosal lesions in patients without confirmed chronic liver disease.
MicroRNA-206 predicts raised fetal growth retardation risk through the interaction with vascular endothelial growth factor in pregnancies
Authors: Li Ying , Liu Jiaqiang 
Published: February 2020

Abstract
This study aimed to investigate the correlation of microRNA (miR)-206, vascular endothelial growth factor (VEGF) and miR-206/VEGF axis at different gestational ages with fetal growth retardation (FGR) risk in pregnancies.
Eight hundred twenty pregnancies were consecutively recruited and their plasma samples were collected at early pregnancy (gestational age ≤ 13 weeks), middle pregnancy (gestational age: 14–27 weeks) and late pregnancy (gestational age ≥ 28 weeks), respectively. miR-206 expression and VEGF level in plasma were detected by quantitative polymerase chain reaction and enzyme-linked immunosorbent assay respectively. FGR was diagnosed based on the actual birth weight of fetus.
miR-206 expression was negatively correlated with VEGF expression at early pregnancy, middle pregnancy and late pregnancy. Besides, miR-206 expression and miR-206/VEGF axis were elevated, but VEGF expression was decreased along with the increased gestational age. There were 74 FGR pregnancies and 746 non-FGR pregnancies. And both miR-206 expression and miR-206/VEGF axis were increased, but VEGF expression was reduced in FGR group compared to non-FGR group at early pregnancy, middle pregnancy and late pregnancy. Additionally, miR-206, VEGF and miR-206/VEGF axis at middle pregnancy and late pregnancy all showed good predictive values for FGR risk, and these indexes at late pregnancy exhibited the numerically highest predictive value for FGR risk. Furthermore, compared to miR-206 or VEGF alone, miR-206/VEGF axis presented with numerically higher predictive value for FGR risk.
miR-206 predicts raised FGR risk through the interaction with VEGF in pregnancies, and it may serve as a novel biomarker for FGR prevention.
Long non-coding RNA small nucleolar RNA host gene 7 expression level in prostate cancer tissues predicts the prognosis of patients with prostate cancer
Authors: Xia Qier , Li Jun , Yang Zhenyu , Zhang Dingguo , Tian Jinjun , Gu Bin 
Published: February 2020

Abstract
Long non-coding small nucleolar RNA host gene 7 (lncRNA SNHG7) is located on chromosome 9q34.3 in length of 984 bp. SNHG7 has been found to play the role of oncogene in varieties of cancers, and its dysregulation has been found to be associated with carcinogenesis and progression. In the present study, we examined the expression of SNHG7 in prostate cancer tissues and in paired adjacent normal prostate tissues, and we further explored the clinical significance and prognostic value of SNHG7 in prostate cancer patients.
A total of 127 prostate cancer tissues were collected from prostate cancer patients who underwent radical prostatectomy between April 2011 and March 2019 at the department of urology, Pudong New Area People's Hospital. Real-time quantitative polymerase chain reaction experiment was performed to detect the relative expressions of SNHG7 in the prostate cancer tissues and normal prostate tissues. The Kaplan–Meier method was used to create survival curves and the log-rank test was used to determine statistical significance. A Cox proportional hazard analysis was used to evaluate the prognostic factors in univariate and multivariate analyses.
Compared with paired adjacent normal prostatic tissues, SNHG7 expression was increased in prostate cancer tissues (P < .001). Increased SNHG7 expression correlated with Gleason score (P = .021), bone metastasis (P = .013), pelvic lymph node metastasis (P = .008), and TNM stage (P = .007). Multivariate Cox regression analyses revealed increased SNHG7 expression was independently associated with a poor prognosis of prostate cancer patients (hazard ratio [HR] = 2.839, 95% confidence interval [CI] = 1.921–8.382, P = .038).
This study showed that lncRNA-SNHG7 was overexpressed in prostate cancer tissues, and it might contributes to the development and progression of prostate cancer. Furthermore, the SNHG7 expression was associated with the prognosis of prostate cancer, suggesting a potential target for the treatment and prognosis of prostate cancer. Nevertheless, the underlying modulatory mechanism by which SNHG7 aggravates prostate cancer progression need to be further studied.
The effect of focused extracorporeal shock wave therapy on myofascial pain syndrome of trapezius
Authors: Yoo Jun-Il , Oh Min-Kyun , Chun Se-Woong , Lee Shi-Uk , Lee Chang Han 
Published: February 2020

Abstract

Background:
Myofascial pain syndrome (MPS) is commonly seen in clinical settings and negatively influences a patient's daily life. Recently, the application of extracorporeal shock wave therapy (ESWT) has been utilized as one of the treatment methods for MPS. The aim of this systematic review and meta-analysis was to summarize the current evidence for the short-term effect of ESWT on MPS of trapezius.

Methods:
PubMed, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials were searched from the database inception to March 2019. Two reviewers independently screened articles, evaluated methodological quality, and extracted data. The primary outcome was post-interventional pain intensity.

Results:
Randomized controlled trials (RCTs) were conducted to determine whether ESWT was used as the main treatment on MPS. The 5 studies reviewed in this meta-analysis were evaluated for changes in pain intensity. Compared with other treatments, focused ESWT in MPS was more effective in reducing the scores of visual analog scale (VAS) (standardized mean difference [SMD] = −0.48, 95% CI −0.74 to −0.22).

Conclusions:
There is very low level evidence that focused ESWT is effective for short-term relief of neck pain in MPS. The limited sample size and poor quality of these studies highlight and support the need for large scale, good quality placebo controlled trials in this area.
Ecological study on needs and cost of treatment for dental caries in schoolchildren aged 6, 12, and 15 years
Authors: Medina-Solís Carlo E. , Ávila-Burgos Leticia , Borges-Yañez Socorro A. , Irigoyen-Camacho María E. , Sánchez-Pérez Leonor , Zepeda-Zepeda Marco A. , Lucas-Rincón Salvador E. , Medina-Solís June J. , Márquez-Corona María de L. , Islas-Granillo Horacio , Casanova-Rosado Juan F. , Casanova-Rosado Alejandro J. , Minaya-Sánchez Mirna , Villalobos-Rodelo Juan J. , Patiño-Marín Nuria , Mendoza-Rodríguez Martha , Pontigo-Loyola América P. , de la Rosa-Santillana Rubén , Escoffié-Ramirez Mauricio , Fernández-Barrera Miguel A. , Maupomé Gerardo 
Published: February 2020

Abstract
To determine the treatment needs and the care index for dental caries in the primary dentition and permanent dentition of schoolchildren and to quantify the cost of care that would represent the treatment of dental caries in Mexico.
A secondary analysis of data from the First National Caries Survey was conducted, which was a cross-sectional study conducted in the 32 states of Mexico. Based on dmft (average number of decayed, extracted, and filled teeth in the primary dentition) and DMFT (average number of decayed, extracted, and filled teeth in permanent dentition) information, a treatment needs index (TNI) and a caries care index (CI) were calculated.

At age 6
, the TNI for the primary dentition ranged from 81.7% to 99.5% and the CI ranged from 0.5% to 17.6%. In the permanent dentition, the TNI ranged from 58.8% to 100%, and the CI ranged from 0.0% to 41.2%.
At age 12
, the TNI ranged from 55.4% to 93.4%, and the CI ranged from 6.5% to 43.4%.
At age 15
, the TNI ranged from 50.4% to 98.4%, and the CI ranged from 1.4% to 48.3%. The total cost of treatment at 6 years of age was estimated to range from a purchasing power parity (PPP) of USD $49.1 to 287.7 million in the primary dentition, and from a PPP of USD $3.7 to 24 million in the permanent dentition. For the treatment of the permanent dentition of 12-year-olds, the PPP ranged from USD $13.3 to 85.4 million. The estimated cost of treatment of the permanent dentition of the 15-year-olds ranged from a PPP of USD $10.9 to 70.3 million. The total estimated cost of caries treatment ranged from a PPP of USD $77.1 to 499.6 million, depending on the type of treatment and provider (public or private).
High percentages of TNI for dental caries and low CI values were observed. The estimated costs associated with the treatment for caries have an impact because they represent a considerable percentage of the total health expenditure in Mexico.
Accuracy augmentation of body composition measurement by bioelectrical impedance analyzer in elderly population
Authors: Fang Wen-Hui , Yang Jie-Ru , Lin Chih-Ying , Hsiao Po-Jen , Tu Ming-Yu , Chen Chien-Fu , Tsai Dung-Jang , Su Wen , Huang Guo-Shu , Chang Hung , Su Sui-Lung 
Published: February 2020

Abstract
Bioelectrical impedance analysis (BIA) is currently the most commonly used method in clinical practice to measure body composition. However, the bioelectrical impedance analyzer is not designed according to different countries, races, and elderly populations. Because different races may have different body compositions, a prediction model for the elderly population in Taiwan should be developed to avoid population bias, thereby improving the accuracy of community evaluation surveys.
Dual energy X-ray absorptiometry (DXA) was used as a standard method for comparison, and impedance analysis was used for the development of a highly accurate predictive model that is suitable for assessing the body composition of elderly people.
This study employed a cross-sectional design and recruited 438 elderly people who were undergoing health examinations at the health management center in the Tri-Service General Hospital as study subjects. Basic demographic variables and impedance analysis values were used in four predictive models, namely, linear regression, random forest, support vector machine (SVM), and eXtreme Gradient Boosting (XGBoost) models, to predict DXA body composition. The data from 354 study subjects were used to develop the predictive model, while the data from 84 study subjects were used to validate the accuracy of the predictive model.
The body composition of elderly people as estimated by InBody 720 was highly correlated with that estimated by DXA. The correlation coefficient between InBody 720 and DXA for muscle mass was 0.969, and that for fat mass was 0.935. Consistency analysis results showed that InBody 720 tends to underestimate muscle mass and fat mass. A comparison of the accuracy of the linear regression, random forest, SVM, and XGBoost models showed that the linear regression has the highest accuracy. The correlation coefficient between the new model and DXA for muscle mass and fat mass were 0.977 and 0.978, respectively.
The new predictive model can be used to monitor the nutrition status of elderly people and identify people with sarcopenia in the community.