bluuebunny/crossref_metadata_2025_split huggingface dataset:
Future planning for individuals with intellectual and developmental disabilities: Perspectives of siblings in South Korea
Authors: Lee Chung eun , Kim Kyung Mee 
Published: September 2020

AbstractBackgroundFuture planning has emerged as a global issue for families of individuals with intellectual and developmental disabilities due to the longer lives and limited long‐term services and supports in the adult disability system. While it has received greater attention, most future planning studies only included parents of individuals with intellectual and developmental disabilities within the context of European or American countries. The purpose of this study was to examine future planning among siblings of individuals with intellectual and developmental disabilities in South Korea.MethodIn this study, 185 Korean siblings of individuals with intellectual and developmental disabilities responded to a survey.ResultsFew siblings engaged in future planning activities and reported a range of barriers to conduct future planning. Further, greater future planning involvement was associated with older siblings, greater advocacy level and greater sibling caregiving.ConclusionFor future research, culturally relevant measures and intervention should be addressed.
Neglected lead tip erosion: An unusual case of S‐ICD inappropriate shock
Authors: Mitacchione Gianfranco , Schiavone Marco , Gasperetti Alessio , Viecca Maurizio , Curnis Antonio , Forleo Giovanni B. 
Published: September 2020

AbstractA 52‐year‐old man experienced a subcutaneous implantable cardioverter‐defibrillator (S‐ICD) inappropriate shock due to electrode tip decubitus. The device, implanted two years before with a three‐incision technique, was extracted, and a new electrode was implanted along the contralateral parasternal line with a two‐incision technique, in a one‐stage procedure. One‐year follow‐up was eventless. Early S‐ICD electrode extraction and reimplantation during the same procedure is effective and should be considered as soon as initial signs of decubitus appear to avoid inappropriate shocks. A two‐incision technique should be preferred to reduce the risk of electrode tip decubitus.
Incidence and clinical impact of early recurrence of atrial tachyarrhythmia after surgical ablation for atrial fibrillation
Authors: Choi Jin Hee , Hwang Ki Won , Jung Soon Myung , Lee Soo Yong , Lee Sang Hyun , Chon Min‐Ku , Kim Jeong‐Su , Je Hyung Gon , Park Yong‐Hyun , Kim June Hong , Lee Sang Kwon , Chun Kook Jin 
Published: September 2020

AbstractBackgroundAtrial tachyarrhythmias (ATAs) are common within the 3‐month blanking period after catheter ablation of atrial fibrillation (AF). However, little evidence is available regarding the current guidelines on the blanking period after surgical AF ablation. We investigate the incidence and significance of early recurrence of atrial tachyarrhythmia (ERAT) and evaluate the optimal blanking period after surgical AF ablation.MethodsData from 259 patients who underwent surgical AF ablation from 2009 to 2016 were collected. ERAT was defined as documented ATA episodes lasting for 30 s. A multivariate Cox proportional hazard model was constructed to evaluate the role of ERAT as a predictor of late recurrences (LR) for AF.ResultsIn total, 127 patients (49.0%) experienced their last episodes of ERAT during the first (n = 65), second (n = 14), or third (n = 48) month of the 3‐month blanking period (p < .001). One year freedom from ATAs was 97.8% in patients without ERAT compared with 95.4%, 64.3%, and 8.3% in patients with ERAT in the first, second, and third months after the index procedure, respectively (p < .001). Hazard ratios of LR according to the timing of the last episode of ERAT first, second, and third months after the procedure were 2.84, 16.70, and 119.75, respectively.ConclusionsThe ERAT occurred in 49.0% of patients within the first 3 months after surgical ablation. The occurrence of ERAT within 3 months after surgical AF ablation was a significant independent predictor of LR. Hence, the currently accepted 3‐month blanking period may be considered for redefining in patients with AF surgical ablation.
miR‐5188 augments glioma growth, migration and invasion through an SP1‐modulated FOXO1‐PI3K/AKT‐c‐JUN‐positive feedback circuit
Authors: Yi Renhui , Yang Shaochun , Lin Xian , Zhong Liangying , Liao Yuanyuan , Hu Zheng , Huang Tengyue , Long Hao , Lin Jie , Wu Zhiyong , Xie Cheng , Ding Shengfeng , Luo Jie , Luo Qisheng , Song Ye 
Published: September 2020

AbstractThe biological effect and molecular mechanism of miR‐5188 have not been thoroughly investigated. The study aims at elucidating the role of miR‐5188 in glioma progression. Human glioma cell lines and tissues were used for functional and expression analysis. Cellular and molecular techniques were performed to explore the functions and mechanisms of miR‐5188 in glioma. In our investigation, we demonstrated that miR‐5188 promoted cell proliferation, the G1/S transition of the cell cycle, migration and invasion in glioma and reduced the lifespan of glioma‐bearing mice. miR‐5188 directly targeted FOXO1 and activated PI3K/AKT‐c‐JUN signalling, which enhanced miR‐5188 expression. Moreover, the c‐JUN transcription factor functionally bound to the miR‐5188 promoter region, forming the positive feedback loop. The feedback loop promoted glioma progression through activating the PI3K/AKT signalling, and this loop is augmented by the interaction between SP1 and c‐JUN. Moreover, it was also found that the miR‐5188/FOXO1 axis is facilitated by SP1‐activated PI3K/AKT/c‐JUN signalling. In glioma samples, miR‐5188 expression was found to be an unfavourable factor and was positively associated with the mRNA levels of SP1 and c‐JUN, whereas negatively associated with the mRNA levels of FOXO1. Our investigation demonstrates that miR‐5188 could function as a tumour promoter by directly targeting FOXO1 and participating in SP1‐mediated promotion of cell growth and tumorigenesis in glioma.
Mechanical stress regulates autophagic flux to affect apoptosis after spinal cord injury
Authors: Zhang Xin , Jing Yingli , Qin Chuan , Liu Changbin , Yang Degang , Gao Feng , Yang Mingliang , Du Liangjie , Li Jianjun 
Published: September 2020

AbstractIncreased mechanical stress after spinal cord injury (SCI) expands the scope of nerve tissue damage and exacerbates nerve function defects. Surgical decompression after SCI is a conventional therapeutic strategy and has been proven to have neuroprotective effects. However, the mechanisms of the interaction between mechanical stress and neurons are currently unknown. In this study, we monitored intramedullary pressure (IMP) and investigated the therapeutic benefit of decompression (including durotomy and piotomy) after injury and its underlying mechanisms in SCI. We found that decreased IMP promotes the generation and degradation of LC3 II, promotes the degradation of p62 and enhances autophagic flux to alleviate apoptosis. The lysosomal dysfunction was reduced after decompression. Piotomy was better than durotomy for the histological repair of spinal cord tissue after SCI. However, the autophagy‐lysosomal pathway inhibitor chloroquine (CQ) partially reversed the apoptosis inhibition caused by piotomy after SCI, and the structural damage was also aggravated after CQ administration. An antibody microarray analysis showed that decompression may reverse the up‐regulated abundance of p‐PI3K, p‐AKT and p‐mTOR caused by SCI. Our findings may contribute to a better understanding of the mechanism of decompression and the effects of mechanical stress on autophagy after SCI.
Inhibitory effect of Ubenimex combined with fluorouracil on multiple drug resistance and P‐glycoprotein expression level in non‐small lung cancer
Authors: Wan Jun , Ling Xie‐an , Wang Jian , Ding Guang‐gui , Wang Xi 
Published: September 2020

AbstractTumour drug resistance is one of the most urgent issues faced by anti‐tumour therapies. P‐glycoprotein (P‐gp) has been reported to be correlated with drug resistance. In this study, we aimed to study the synergistic effect of fluorouracil (5FU) and Ubenimex (UBE) on drug resistance in lung cancer. In this study, the tumour inhibitory role of 5FU and UBE was assessed in nude mice bearing A549 or A549/ADR. Real‐time polymerase chain reaction, Western blot and immunohistochemical were performed to analyse the mRNA and protein expression of P‐gp. TUNEL assay was used to evaluate the apoptosis of A549/ADR cells under 5FU and UBE treatment. MTT assay was performed to calculate the IC50 value of 5FU and UBE in A549 or A549/ADR. Combined administration of 5FU and UBE significantly inhibited the tumour growth of multidrug‐resistant cell lines A549/ADR in nude mice by down‐regulating the mRNA and protein expression of P‐gp. The apoptosis of A549/ADR was remarkably elevated in nude mice treated with 5FU and UBE. The IC50 value of 5FU and UBE was dramatically declined in A549/ADR cells compared with that of 5FU or UBE alone. Combined treatment of 5FU and UBE remarkably enhanced the apoptosis of A549/ADR cells by enhancing the intracellular accumulation of the drugs. The results of this study demonstrated that UBE combined with fluorouracil attenuated multiple drug resistance and inhibited the expression of P‐gp in lung cancer.
A novel danshensu derivative ameliorates experimental colitis by modulating NADPH oxidase 4‐dependent NLRP3 inflammasome activation
Authors: Pan Li‐Long , Ren Zhengnan , Liu Yanyan , Zhao Yalei , Li Hongli , Pan Xiaohua , Fang Xin , Liang Wenjie , Wang Yang , Yang Jun , Sun Jia 
Published: September 2020

AbstractWe have previously reported a novel compound [4‐(2‐acetoxy‐3‐((R)‐3‐(benzylthio)‐1‐methoxy‐1‐oxopropan‐2‐ylamino)‐3‐oxopropyl)‐1,2‐phenylene diacetate (DSC)], derived from danshensu, exhibits cytoprotective activities in vitro. Here, we investigated the effects and underlying mechanisms of DSC on dextran sodium sulphate (DSS)‐induced experimental colitis. We found that DSC treatment afforded significant protection against the development of colitis, evidencing by suppressed inflammatory responses and enhanced barrier integrity. Intriguingly, DSC specifically down‐regulated DSS‐induced colonic NADPH oxidase 4 (Nox4) expression, accompanied by a balanced redox status, suppressed nuclear factor‐κB (NF‐κB) and NLRP3 inflammasome activation and up‐regulated nuclear factor (erythroid‐derived 2)‐like 2 and haeme oxygenase‐1 expression. In vitro study also demonstrated DSC also markedly decreased Nox4 expression and activity associated with inhibiting reactive oxygen species generation, NF‐κB activation and NLRP3 inflammasome activation in bone marrow‐derived macrophages. Either lentiviral Nox4 shRNA‐mediated Nox4 knockdown or Nox4‐specific small‐interfering RNA mimicked effects of DSC by suppressing NLPR3 inflammasome activation to alleviate experimental colitis or inflammatory macrophage response. Collectively, our results provide the first evidence that DSC ameliorates experimental colitis partly through modulating Nox4‐mediated NLRP3 inflammasome activation.
Periodontal regeneration using a xenogeneic bone substitute seeded with autologous periodontal ligament‐derived mesenchymal stem cells: A 12‐month quasi‐randomized controlled pilot clinical trial
Authors: Sánchez Nerea , Fierravanti Ludovica , Núñez Javier , Vignoletti Fabio , González‐Zamora María , Santamaría Silvia , Suárez‐Sancho Susana , Fernández‐Santos María Eugenia , Figuero Elena , Herrera David , García‐Sanz Jose A. , Sanz Mariano 
Published: September 2020

AbstractAimTo evaluate the safety and efficacy of autologous periodontal ligament‐derived mesenchymal stem cells (PDL‐MSCs) embedded in a xenogeneic bone substitute (XBS) for the regenerative treatment of intra‐bony periodontal defects.Material and MethodsThis quasi‐randomized controlled pilot phase II clinical trial included patients requiring a tooth extraction and presence of one intra‐bony lesion (1–2 walls). Patients were allocated to either the experimental (XBS + 10 × 106 PDL‐MSCs/100 mg) or the control group (XBS). Clinical and radiographical parameters were recorded at baseline, 6, 9 and 12 months. The presence of adverse events was also evaluated. Chi‐square, Student's t test, Mann–Whitney U, repeated‐measures ANOVA and regression models were used.ResultsTwenty patients were included. No serious adverse events were reported. Patients in the experimental group (n = 9) showed greater clinical attachment level (CAL) gain (1.44, standard deviation [SD] = 1.87) and probing pocket depth (PPD) reduction (2.33, SD = 1.32) than the control group (n = 10; CAL gain = 0.88, SD = 1.68, and PPD reduction = 2.10, SD = 2.46), without statistically significant differences.ConclusionThe application of PDL‐MSCs to XBS for the treatment of one‐ to two‐wall intra‐bony lesions was safe and resulted in low postoperative morbidity and appropriate healing, although its additional benefit, when compared with the XBS alone, was not demonstrated.
The burden in chronic prurigo: patients with chronic prurigo suffer more than patients with chronic pruritus on non‐lesional skin
Authors: Zeidler C. , Pereira M.P. , Dugas M. , Augustin M. , Storck M. , Weyer‐Elberich V. , Schneider G. , Ständer S. 
Published: September 2020

AbstractBackgroundChronic prurigo (CPG) is known as a high burdensome disease characterized by severe pruritus and multiple pruriginous lesions. Interestingly, the disease‐specific burden is not well established and there are no data which compare the impact of CPG with chronic pruritus (CP) on non‐lesional skin (CP‐NL).ObjectivesTo address this issue, we analysed datasets from 4484 patients with either CPG or CP‐NL.MethodsDemographic medical data and additional information collected by validated patient reported outcome tools were analysed. The visual analogue scale and numerical rating scale (NRS) were used for assessing the pruritus intensity, the ItchyQoL for patients' quality of life, the Hospital Anxiety and Depression Scale and the Patient Needs Questionnaire' as a part of Patient Benefit Index for Pruritus for measuring the importance of 27 patient needs in terms of treatment goals. The Neuroderm questionnaire was used to assess the history of pruritus characteristics and the impact on sleep.ResultsPatients with CPG suffered longer and with a higher intensity from pruritus [NRS worst the last 24 h, CPG 6.0 (4.0;8.0) vs. CP‐NL 3.0 (5.0;7.0), P < 0.001]. In them, pruritus occurred more often and the whole day and night which led to more loss in sleeping hours [CPG 3.0 h (2.0;4.0) vs. CP‐NL 2.0 h (1.0;4.0), P < 0.001]. Patients with CPG showed higher scores for depression [HADS‐D, CPG 6.0 (3.0;10.0) vs. CP‐NL 5.0 (2.0;8.0), P < 0.001], more impaired quality of life [ItchyQol; CPG: 72.6 (61.6;83.6) vs. CP‐NL 59.4 (48.4;70.4), P < 0.001] and higher weighted needs in the predefined treatment goals.DiscussionNot only the presence of severe pruritus and pruriginous lesions but also sleep disorders and other mental symptoms may contribute to a higher burden in patients with CPG when compared with patients with CP‐NL.
The Chronic Urticaria Registry: rationale, methods and initial implementation
Authors: Weller K. , Giménez‐Arnau A. , Grattan C. , Asero R. , Mathelier‐Fusade P. , Bizjak M. , Hanna M. , Maurer M. ,   the CURE Investigators
Published: September 2020

AbstractBackgroundChronic urticaria (CU) is a common disease, characterized by the recurrent appearance of wheals, angioedema or both for more than 6 weeks. Its underlying biology is not well understood, and many patients do not obtain sufficient relief from recommended treatments. Patient registries are rapidly growing as a form of research, because they can provide powerful, data‐driven insights about the epidemiology of diseases, real‐world effectiveness of treatments, rare patient types, safety monitoring, healthcare costs and opportunities for quality improvement of healthcare delivery.ObjectivesThe Chronic Urticaria Registry (CURE) has been designed to improve the scientific understanding, clinical treatment and healthcare planning of CU patients. This report describes the rationale, methods and initial implementation of this registry.MethodsChronic Urticaria Registry is an ongoing, prospective, international, multicentre, observational, voluntary registry of patients with CU. Participation in CURE is open to any physician treating CU patients, regardless of location, medical specialty or type of practice setting. CURE aims to collect data on all CU patients, with no intentional selection or exclusion criteria. It collects baseline and follow‐up data on the patient's demographics, history, symptoms, trigger and risk factors, therapies and healthcare utilization.ResultsChronic Urticaria Registry is a landmark achievement of the global urticaria medical community. As of 26 February 2020, 39 centres around the world have joined the registry and 35 have entered baseline data on a total of 2946 patients. Publications of this data will be forthcoming soon.ConclusionsChronic Urticaria Registry is eagerly seeking the participation of more physicians and the support of more governmental, charitable and commercial sponsors from around the world. Here, in this paper, we invite other physicians to join this unique project to improve the lives of patients with CU.
Changing trends in surgical hair restoration: Use of Google Trends and the ISHRS practice census survey
Authors: Gupta Aditya K. , Quinlan Emma M. 
Published: September 2020

AbstractBackgroundHair loss affects most people at some point in their lifetime, causing anxiety and decreased self‐esteem. There are multiple surgical and nonsurgical treatments available, with the surgical options having greater and longer‐lasting effects. Such treatments have evolved over time with advances in technology and research, with numerous patients researching these treatments on Google. Many surgeons who provide these treatments belong to the International Society of Hair Restoration Surgeons (ISHRS).AimsTo investigate trends in surgical hair restoration treatment from both the surgeon and patient perspectives.MethodsPatient epidemiological and surgical data from the ISHRS were combined with search trend data from Google to analyze changing trends in surgical hair restoration treatment.ResultsWorldwide Internet searches for “hair transplant” have increased from 2004 to the present. Follicular unit excision (FUE) has supplanted follicular unit transplant (FUT) as the most popular hair transplant performed. Since 2004, there has been an increase in both nonsurgical and surgical female patients. Beard and eyebrow transplants have increased in popularity. Google searches follow this trend. Nonsurgical treatments such as platelet‐rich plasma (PRP) are being searched more frequently. Hair restoration clinics and Google searches were affected adversely by the COVID‐19 pandemic.ConclusionTechnological advances in available therapies, improvement in delivery systems, changes in hair fashion, and global events have direct impact on hair restoration treatments offered by physicians and researched by patients. It is in the best interest of all hair restoration providers to keep abreast of changing technologies and treatment trends to stay at the forefront of their profession.
Implications of cigarette smoking on early‐onset androgenetic alopecia: A cross‐sectional Study
Authors: Salem Ahmed S. , Ibrahim Hany S. , Abdelaziz Heba H. , Elsaie Mohamed L. 
Published: September 2020

BackgroundAndrogenetic alopecia (AGA) is a condition affecting both males and females. Aims We aimed to assess the demographic and clinical features of early‐onset AGA among smokers and nonsmokers and to evaluate whether prevalence of AGA was affected by smoking.Paatients/MethodsOne thousand (1000) healthy males aged between 20 and 35 years not complaining of any local scalp condition and free of any mental illness were recruited for this study and divided into two groups of 500 each based on their smoking attitudes. Androgenetic alopecia was classified according to the Hamilton baldness scale, and trichoscopy was used to confirm the diagnosis of AGA. A designed questionnaire to determine basic physical and smoking habits completed and results was interpreted and analyzed.ResultsThe majority of smokers (425) had a form of AGA, while only (200) nonsmokers had a degree of AGA (P < .01). Of the smokers group, 235 (47%) had grade III AGA and 120 subjects (24%) had grade IV AGA. In the nonsmokers group, 100 subjects (20%) had grade II AGA and 50 subjects (10%) had either grade III or IV AGA.ConclusionThe prevalence of AGA among smokers was statistically higher than among nonsmokers, while severity of AGA was not associated with the intensity of smoking. Nicotine and its derivative cotinine might be responsible for accelerating AGA progress pending further validation.
Risk of occult atypical hyperplasia or cancer in women with nonatypical endometrial hyperplasia
Authors: Lee Nara , Lee Kwang‐Beom , Kim Kidong , Hong Jin Hwa , Yim Ga Won , Seong Seok Ju , Lee Banghyun , Lee Jong‐Min , Cho Jaehyun , Lim Soyi , Ouh Yung‐Taek , Kim Yong Beom 
Published: September 2020

AbstractAimThe aim of this study was to identify subsets of patients diagnosed with nonatypical endometrial hyperplasia (NAEH) by endometrial biopsy who had high risk for occult atypical endometrial hyperplasia (AEH) or endometrial cancer (EC).MethodsWe retrospectively reviewed the medical records of 281 patients who underwent hysterectomy within 6 months after a diagnosis of NAEH. We collected data on age, body mass index, menopausal status, tamoxifen use, previous history of NAEH, details of endometrial biopsy (location, curettage vs. pipelle sampling), NAEH subtype (simple vs. complex), interval between endometrial biopsy and hysterectomy, indication of hysterectomy and the presence of occult AEH or EC in hysterectomy specimen. Associations between variables and occult AEH or EC were analyzed. Risk of occult AEH or EC in subsets were calculated and visualized using a heatmap.ResultsAmong 281 patients, 34 (12.1%) and 9 (3.2%) had occult AEH and EC in hysterectomy specimens, respectively. Using univariate analysis, we found age, menopausal status and subtype were associated with occult AEH or EC. Using multivariate analysis, older age (odds ratio = 1.09, P < 0.01) and complex subtype (odds ratio = 3.34, P < 0.01) were independent risk factors. Patients at an age ≥ 51 years with complex NAEH had about 50% risk of occult AEH or EC.ConclusionWomen at an age ≥ 51 years with complex NAEH had high risk for occult AEH or EC and surgical treatment can be considered for these patients.