bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Treatment of a Widespread Pemphigus Chronicus Familiaris (Hailey-Hailey) By Erbium-YAG-Laser
Authors: Wollina Uwe , Hansel Gesina , Lotti Torello , Vojvodic Aleksandra 
Published: November 2019

BACKGROUND: Familial chronic pemphigus or Hailey-Hailey disease (OMIM 169600) is a rare, autosomal dominant blistering skin disorder the genetic background are mutations of the ATP2 C1 gene. The treatment is challenging.
CASE REPORT: A 48-year-old Caucasian female patient presented to the department with a relapse of her Pemphigus chronicus familiaris (Hailey-Hailey). No other medical diseases were known. On examination, we observed an otherwise healthy woman with widespread erosive lesions on the neck, axillae, groins, submammary fold and anal fold. She reported burning sensations and an unpleasant odour. The diagnosis had been confirmed earlier by histopathology of a skin biopsy with acantholysis, and the relapsing and remitting course. Family history was positive for father and brother. Since she had not responded well in the past to systemic retinoids and did not tolerate the adverse effects of these drugs, we suggested an ablative erbium-YAG laser treatment in general anaesthesia. Laser treatment was performed with the MCL 29 Dermablate (Asclepion Laser Technologies, Jena, Germany) on two occasions. We used a 5 mm focus, pulse energy of 1200 mJ at 8 Hz. The resulting superficial wounds were treated with an ointment containing fusidic acid 0.2% and betamethasone 0.1%. Wound healing was completed after 12 days. No adverse events were observed.
CONCLUSIONS: Ablative erbium-YAG therapy is an option for pemphigus chronicus familiaris, in particular in young women and patients who do not tolerate the adverse effects of retinoid therapy.
Brass'Art in Molenbeek: stadslaboratorium voor “samen doen”
Authors: Fadil Nadia , Kolly Maryam 
Published: November 2019

Dit artikel neemt het geval van het cultuurcafé Brass’Art, gelegen op het gemeenteplein in Molenbeek, als uitgangspunt van een studie om meer inzicht te krijgen in de opbouw van een stedelijke gemeenschappelijke ruimte met een pluralistische bestemming. Op basis van een etnografie tussen mei 2017 en januari 2018 wil dit artikel aantonen hoe de aanwezigheid van alcohol op deze plek verschillende en zelfs tegenstrijdige registers – van discursieve, ethische en affectieve aard – aanvoert en concentreert, die de samenstelling van de openbare ruimte activeren. De casestudy van Brass’Art is emblematisch omdat die op lokale microschaal de gevolgen weergeeft van een co-existentie tussen actoren met gevoeligheden en diverse religieuze voorkeuren. Volgens een pragmatische methodologie tracht dit artikel aan te tonen dat het subtiele hernieuwde evenwicht van de machtsverhouding tussen meerder- en minderheden niet zozeer het resultaat is van bewuste onderhandelingen of strategieën van “burgerlijke onverschilligheid” maar wel van praktische aanpassingen van het principe van “samen doen”.
Secondary Prevention of Hyperlipidemia After Coronary Artery Bypass Graft: From Acute Care to Primary Care
Authors: Brackbill Marcia L. , Sytsma Christine 
Published: November 2019

• Background Clinical trials have established that secondary prevention of hyperlipidemia in patients after coronary artery bypass graft (CABG) surgery prevents progression of atherosclerosis. A multidisciplinary team promotes secondary prevention by prescribing antihyperlipidemic agents, screening for risk factors, and providing education on disease, diet, and medications. Information is minimal on the number of patients who continue with antihyperlipidemic therapy or follow-up with a primary care provider for cholesterol management after antihyperlipidemic therapy is initiated in an acute surgical setting.• Objectives To determine (1) the frequency of use of antihyperlipidemic agents before CABG surgery, at hospital discharge, and approximately 9 months after discharge and (2) the occurrence of cholesterol monitoring by a primary care provider at least once between discharge and telephone follow-up.• Methods Observational study of 135 patients undergoing CABG surgery at a regional medical center during a 4-month period. Patients were contacted by telephone between 5 and 12 months after discharge and asked about continued use of antihyperlipidemic agents and cholesterol monitoring since discharge.• Results Before surgery, 56% of the patients were taking an antihyperlipidemic agent. At discharge, 95% were taking an antihyperlipidemic agent. At the time of study follow-up, 91% were still taking an antihyperlipidemic agent, and 84% had follow-up cholesterol monitoring by their primary care provider.• Conclusion Initiation of an antihyperlipidemic agent and provision of education during hospitalization for CABG surgery results in a high percentage of patients continuing antihyperlipidemic therapy and having cholesterol levels monitored by their primary care provider after discharge.
Lived Experience of Critically Ill Patients’ Family Members During Cardiopulmonary Resuscitation
Authors: Wagner Jennifer M. 
Published: November 2019

• Background During resuscitative efforts, patients’ family members are often barred from the patients’ rooms and may never have the opportunity to see their loved ones alive again. Recently, the need to ask family members to leave the room is being questioned. Little is known about families’ perceptions of cardiopulmonary resuscitation.• Objective To describe the experiences, thoughts, and perceptions of family members of critically ill patients during cardiopulmonary resuscitation in the intensive care unit.• Method Six family members whose loved ones underwent cardiopulmonary resuscitation and survived consented to an audiotaped interview. During the interview, family members were asked to describe their experiences during the resuscitation. Interviews were transcribed and were analyzed for relevant themes by using Van Manen thematic analysis.• Results One major theme emerged: Should we go or should we stay? Additionally, 2 subthemes emerged: What is going on? and You do your job. A model, the family’s experience with cardiopulmonary resuscitation, was developed to reflect the research findings.• Conclusions During the period of resuscitation, healthcare professionals neglect to recognize that patients’ family members are experiencing crisis along with the patients and that coping mechanisms are impaired. Moreover, the family members’ informational and proximity needs are often ignored during this time of crisis. Addressing these needs through appropriate nursing interventions will become increasingly important as patients’ family members begin to remain with their loved ones during cardiopulmonary resuscitation.
IL-17 Promotes Pseudomonas aeruginosa Keratitis in C57BL/6 Mouse Corneas
Authors: Me Rao , Gao Nan , Dai Chenyang , Yu Fu-shin X. 
Published: November 2019

Abstract
The aim of this study was to elucidate the expression and functions of IL-17 in C57BL/6 mouse corneas in response to Pseudomonas aeruginosa infection. We found that P. aeruginosa infection induced and increased signaling of IL-23/23R/17/17R in mouse corneas. Targeting IL-17A or the IL-17A–specific receptor IL-17RA/IL-17RC with neutralizing Abs resulted in a significant decrease in the severity of P. aeruginosa keratitis, including a decrease in bacterial burden and polymorphonuclear leukocyte infiltration. IL-17A–signaling blockade also significantly reduced the expression of the proinflammatory cytokines L-1β, IL-24, and MMP-13 and increased the expression of the anti-inflammatory cytokine IL-1RA in mouse corneal epithelium. The presence of mouse IL-17A exacerbated P. aeruginosa–mediated tissue destruction. A cytokine protein array revealed that the expression of osteoprotegerin (OPG) was regulated by IL-17A, and OPG neutralization also resulted in a decrease in the severity of P. aeruginosa keratitis. Although both IL-17 and OPG affected the balanced expression of IL-1β and IL-1RA, only IL-17 inhibited the expression of TH2 cytokines. Taken together, our results revealed that IL-17A, along with its downstream factor OPG, plays a detrimental role in the pathogenesis of P. aeruginosa keratitis. Targeting IL-17A and/or the OPG/RANKL/RANK/TRAIL system is a potential therapeutic strategy in controlling the outcome of P. aeruginosa keratitis, which was demonstrated by concurrent topical application of IL-17A–neutralizing Ab and ciprofloxacin in B6 mice.
Functional Role of T-tubules on Calcium Transients in Canine Cardiac Myocytes
Authors: Barnes Alicia A. , Williams Zachary E. , Olzcyk Samuel , Cooke Alida , Cordeiro Jonathan A. , Zeina Tanya , Mathew Rueben , Treat Jacqueline A. , Aistrup Gary L. , Cordeiro Jonathan M. 
Published: November 2019

Background:
A loss of t-tubules and alterations in ultrastructure occur in cultured ventricular myocytes. A similar alteration in t-tubules and ultrastructure is well documented under certain pathological conditions such as heart failure. We examined the ultrastructural changes in cultured canine cardiac cells and determined the functional impact these changes have on excitation-contraction coupling and Ca2+ transients.

Materials, Methods and Results:
Atrial, ventricle, and Purkinje myocytes were isolated by enzymatic dispersion. Atrial and ventricular myocytes were cultured for up to 48 h. Voltage clamp recordings were made with patch electrodes. Ca2+ transient was recorded as a laser scanning confocal microscope in myocytes loaded with Ca2+ fluorescent dyes. Membrane ultrastructure was imaged in myocytes stained with the membrane selective dye, di-8-ANEPP. Freshly isolated ventricular myocytes had a well-developed t-tubule system, while Purkinje cells had no t-tubules; some atrial cells exhibited a primitive t-tubule system. In atrial and Purkinje cells, the Ca2+ transient had a U-shaped profile with the fluorescence highest at the edge of the cell. In contrast, ventricular myocytes showed a homogeneous rise in Ca2+ at the edge and center of cells. Ventricular myocytes cultured for 2 days showed a nearly complete loss of t-tubules. The Ca2+ transients revealed a phenotypic switch from a homogeneous profile to a “U”-shaped profile. Interestingly, atrial cells in culture maintained their primitive t-tubule system.

Conclusions:
Our results show that atrial and ventricular myocytes respond differently to being placed in culture. Ventricular myocytes, but not atrial myocytes, quickly lose their t-tubules accompanied by a Ca2+ transient profile suggestive of a phenotypic switch in Ca2+ handling. The differential response also suggests that the various cardiac tissue types would respond differently to pathophysiological stresses.
Cost-Efficient Medical Education: An Innovative Approach to Creating Educational Products
Authors: Kaplovitch Eric , Otremba Mirek , Morgan Matthew , Devine Luke A. 
Published: November 2019

ABSTRACT

Background
Cost is a barrier to creating educational resources, and new educational initiatives are often limited in distribution. Medical training programs must develop strategies to create and implement cost-effective educational programming.

Objective
We developed high-quality medical programming in procedural instruction with efficient economics, reaching the most trainees at the lowest cost.

Methods
The Just-In-Time online procedural program was developed at the University of Toronto in Canada, aiming to teach thoracentesis, paracentesis, and lumbar puncture skills to internal medicine trainees. Commercial vendors quoted between CAD $50,000 and $100,000 to create 3 comprehensive e-learning procedural modules—a cost that was prohibitive. Modules were therefore developed internally, utilizing 4 principles aimed at decreasing costs while creating efficiencies: targeting talent, finding value abroad, open source expansion, and extrapolating efficiency.

Results
Procedural modules for thoracentesis, paracentesis, and lumbar puncture were created for a total cost of CAD $1,200, less than 3% of the anticipated cost in utilizing traditional commercial vendors. From November 2016 until October 2018, 1800 online instructional sessions have occurred, with over 3600 pageviews of content utilized. While half of the instructional sessions occurred within the city of Toronto, utilization was documented in 10 other cities across Canada.

Conclusions
The Just-in-Time online instructional program successfully created 3 procedural modules at a fraction of the anticipated cost and appeared acceptable to residents based on website utilization.
Monochrome
Authors: Staff Craig 
Published: November 2019

The monochrome - a single colour of paint applied over the entirety of a canvas - remains one of the more contentious modernist artistic inventions. But whilst the manufacture of these 'pictures of nothing' was ostensibly straightforward, their subsequent theorisation has been anything but. More than a history, Monochrome: Darkness and Light in Contemporary Art is the first account of the monochrome's lively role in contemporary art. Liberated from the burden of representation, the monochrome first stood for emancipation: an ideological and artistic impulse that characterised the avant-garde of the early twentieth century. Historically, the monochrome embodied the most extreme form of abstraction and pure materiality. Yet more recently, adaptations of the art form have focused on a broader range of cultural and interpretive contexts. Provocative, innovative and timely, this book argues that the latest artistic strategies go beyond stylistic concerns and instead seek to re-engage with ideas around authorship, process and the conditions of the visible as they are given and understood through both light and darkness.
Discussing works by artists such as Katie Paterson, Hiroshi Sugimoto, Tom Friedman, Bruno Jakob, Sherrie Levine and Ceal Floyer, the book shows that the debates around an artwork's form and its possibility for meaning that the monochrome first engendered remain very much alive in contemporary visual culture.
Renegotiating the Body
Authors: Battista Kathy 
Published: November 2019

What makes art 'feminist art'? Although feminist artists do have a unique aesthetic, there can be no essential feminist aesthetic, argues Kathy Battista in this exciting new art history. Domesticity, the body, its traces and sexuality have become prominent themes in contemporary feminist practice but where did these preoccupations begin and how did they come to signify a particular type of art? Kathy Battista's (re-)engagement with the founding generation of female practitioners centres on 1970s London as the cultural hub from which a new art practice arose. Emphasising the importance of artists including Bobby Baker, Anne Bean, Catherine Elwes, Rose English, Alexis Hunter, Tina Keane, Hannah O'Shea, Kate Walker and Silvia Ziranek and examining works such as Mary Kelly's Post-Partum Document, Judy Clark's 1973 exhibition Issues, Carolee Schneemann's Meat Joy and Cosey Fanni Tutti's Prostitution, shown in 1976, Kathy Battista investigates some of the most controversial and provocative art from the era.
This book not only deals with the 'famous' art events but includes analysis of lesser-known exhibitions and performances and explains why so much feminist art has been both marginalised in art history and grossly under-represented in institutional archives and collections.
Performing the East
Authors: Bryzgel Amy 
Published: November 2019

Performance art in Western Europe and North America developed in part as a response to the commercialisation of the art object, as artists endeavoured to create works of art that could not be bought or sold. But what are the roots of performance art in Eastern Europe and Russia, where there was no real art market to speak of? While many artworks created in the 'East' may resemble Western performance art practices, their origins, as well as their meaning and significance, is decidedly different. By placing specific performances from Russia, Latvia and Poland from the late- and post-communist periods within a local and international context, this book pinpoints the nuances between performance art East and West. Performance art in Eastern Europe is examined for the first time as agent and chronicle of the transition from Soviet and satellite states to free-market democracies. Drawing upon previously unpublished sources and exclusive interviews with the artists themselves, Amy Bryzgel explores the actions of the period, from Miervaldis Polis's Bronze Man to Oleg Kulik's Russian Dog performances.
Bryzgel demonstrates that in the late-1980s and early 1990s, performance art in Eastern Europe went beyond the modernist critique to express ideas outside the official discourse, shocking and empowering the citizenry, both effecting and mirroring the social changes taking place at the time. Performing the East opens the way to an urgent reassessment of the history, function and meaning of performance art practices in East-Central Europe.
Art and Architecture
Authors: Rendell Jane 
Published: November 2019

The last twenty years have seen fascinating developments in the nature of collaboration between artists and architects and in the approaches taken by artists making work intended for public spaces. These sophisticated projects go far beyond the standard 'art for architecture' remit, limited as it is to the addition of 'artworks' to already designed buildings, the work described here invites us to rethink the reputation that public art has acquired over the years amongst both the public and the artists themselves. Timely and wide-ranging, "Art and Architecture" explores the proliferation of recent pioneering work by both artists and architects that seeks to blur traditional boundaries between the two fields. Looking back to precedents in land and community art by artists from Robert Smithson and Walter de Maria to Mierle Laderman Ukeles and Joseph Beuys, Rendell discusses international projects by artists including Tacita Dean, Krzysztof Wodiczko, Paul Pfeiffer and Rachel Whiteread and architects as varied as Rem Koolhaas, Daniel Libeskind, Diller + Scofidio and Shigeru Ban.
She visits 'site-specific' artworks, interventions into existing buildings, galleries operating outside their physical limits and the best of collaborations between the fields. More than a survey, however, "Art and Architecture" also draws on the work of thinkers from Walter Benjamin to Michel de Certeau to probe the meanings of place, space and site.
Triumph of a Time Lord
Authors: Hills Matt 
Published: November 2019

Before Saturday March 26th 2005, "Doctor Who" had been off the air as a regular, new TV series for more than fifteen years; until a production team led by Russell T. Davies re-imagined the programme so successfully, so triumphantly, that it's become an instant Christmas tradition, a BAFTA winner, an international 'superbrand' and a number one rated show. It's even been credited with reinventing family TV. This is the first full-length book to explore the 'new Who' phenomenon through to the casting of Matt Smith as the new Doctor. It explores "Doctor Who" through contemporary debates in TV Studies about quality TV and how can we define TV series as both 'cult' and 'mainstream'. Further, the book challenges assumptions in focusing on the importance of breath-taking, dramatic moments along with narrative structures, and in analysing the significance of Murray Gold's music as well as the series' visual representations. Matt Hills is a lifelong "Who" fan and he also considers the role of fandom in the show's return. He investigates too the multi-generic identity, the monster-led format, and the time-travelling brand of BBC Wales' 'Doctor Who'.
In the twenty-first century, TV is changing, but the last of the Time Lords has been more than ready: he's been fantastic.
TV Horror
Authors: Jowett Lorna , Abbott Stacey 
Published: November 2019

Horror is one of the most pervasive of contemporary TV genres with shows like True Blood, Being Human, The Walking Dead and American Horror Story making a bloody splash across our television screens. Yet not too long ago critics and horror writers claimed that television and horror were incompatible bedfellows. TV Horror: Investigating the Dark Side of the Small Screen explores the often contradictory relationship between horror and television and shows how this most adaptable genre has continued to be a part of the broadcast landscape, unsettling audiences and pushing the boundaries of acceptability. Lorna Jowett and Stacey Abbott demonstrate how TV horror continues to provoke and terrify audiences by bringing the monstrous and the supernatural into the home, whether through adaptations of Stephen King and classic horror novels, or by reworking the gothic and surrealism in Twin Peaks and Carnivale.
They uncover the omnipresence of horror in mainstream television from procedural dramas to children’s television and, through close analysis of landmark TV auteurs including Rod Serling, Nigel Kneale, Dan Curtis and Steven Moffat, as well as case studies of Dark Shadows, Dexter, The League of Gentlemen, Pushing Daisies, Torchwood, and Supernatural. They expand debates about the nature of horror by exploring its evolution on television. The historical breadth of the discussion, alongside detailed analysis of an exciting and diverse selection of television series, makes this book a must-have for those studying TV genre, as well as for anyone with a taste for the gruesome and the macabre.
Black Transhuman Liberation Theology
Authors: Butler Philip 
Published: November 2019

Edition description: This book proposes freedom through an unlikely source: science. Mediating Black religious studies and liberation theology, Philip Butler explores how Black Americans can utilize technology in conjunction with their spirituality in the fight towards materializing freedom.
The discussions shaping what it means for humans to exist with technology and as part of technology are already underway – transhumanism suggests that any use of technology to augment intellectual, psychological or physical capability makes one transhuman. Black Transhuman Liberation Theology explores the role technology already plays in the lives of Black Americans, and considers the possibility for technology to be used as a liberative tool.
Addressing some of the issues that have prevented Black Americans from participating in science, technology and even science fiction, the book engages how religion, medical abuse and the perception of the Black intellect in America have served as barriers. It takes a critical scientific approach to understanding the biological embodiment of Black spiritual practices, and projects how current and emerging technologies can be aligned with spiritually generative biological states to physically deconstruct oppressive societal structures.
Fighting Proud
Authors: Bourne Stephen 
Published: November 2019

“In this astonishing new history of wartime Britain, historian Stephen Bourne unearths the fascinating stories of the gay men who served in the armed forces and at home, and brings to light the great unheralded contribution they made to the war effort. Fighting Proud weaves together the remarkable lives of these men, from RAF hero Ian Gleed - a Flying Ace twice honoured for bravery by King George VI - to the infantry officers serving in the trenches on the Western Front in WWI - many of whom led the charges into machine-gun fire only to find themselves court-martialled after the war for indecent behaviour. Behind the lines, Alan Turing's work on breaking the ‘enigma machine’ and subsequent persecution contrasts with the many stories of love and courage in Blitzed-out London, with new wartime diaries and letters unearthed for the first time. Bourne tells the bitterly sad story of Ivor Novello, who wrote the WWI anthem ‘Keep the Home Fires Burning’, and the crucial work of Noel Coward - who was hated by Hitler for his work entertaining the troops. Fighting Proud also includes a wealth of long-suppressed wartime photography subsequently ignored by mainstream historians.
This book is a monument to the bravery, sacrifice and honour shown by a persecuted minority, who contributed during Britain's hour of need.”