bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Reach of Conceptual Models Used in Ageism and Dementia Studies: A Scoping Review
Authors: Rahman Atiqur , Hyden Lars-Christer 
Published: December 2020

Abstract
Older adults are discriminated against at different social levels- called ageism and the people living with dementia (PlwD) not only face ageism due to being elder but also encounter prejudices, negative attitudes and discrimination because they live with dementia. The purpose of this review is to highlight the different conceptual and methodological approaches used and the groups being investigated as well as the findings from studies in the combined research field of ageism and dementia. Five scientific databases were used within a timeframe between 2009 and 2018. A total number of 98 articles (quantitative, qualitative, and mixed methods) were included and analyzed based on (i) the conceptual frameworks, (ii) methodological approaches, (iii) groups studied, and (iv) findings. The result emerged six themes (i) stereotypes and attitudes in the general population; (ii) stereotypes and attitudes of themselves; (iii) stereotypes and attitudes among staff; (iv) stereotypes and attitudes as part of culture; (v) stereotypes and attitudes of family members; and (vi) miscellaneous. The principal findings identified lower education, lack of knowledge and less information about dementia as the main contributing factors to manifest stereotypes, attitudes, and ageism in society toward PlwD that leads to stigma. Moreover, this review found few studies were based on explicit conceptual frameworks but rather on descriptive understandings of relations between attitudes. There is a domination of the quantitative approach where the target populations were mostly from Western regions. The review suggests that a more conceptually coherent approach would allow for a better cumulative building of knowledge.
Best of Both Worlds: Bridging Research and Practice to Achieve Health Equity
Authors: Lincoln Karen 
Published: December 2020

Abstract
Health inequity is linked to societal and social determinants that constrain health promoting opportunities for older adults. From birth to death, many older adults contend with the prevailing social and health effects of discrimination in employment, education, and housing. As a consequence, middle-aged Black Americans are experiencing accelerated aging, and living with and dying from preventable chronic health conditions typically diagnosed at older ages. Despite these conditions, there is much variation in health outcomes among older Black Americans. Professor Karen Lincoln will share her approach to research that explores heterogeneity within the Black American population to discover factors that promote healthy aging. She will describe her unique outreach and health education program that serves older adults in underserved communities, and her roles as an aging advocate and public scholar. She will discuss how these experiences led to the development and testing of an innovative intervention to reduce Alzheimer’s disease disparities.
Successful Informal Help-Seeking and Resolution of Elder Family Financial Exploitation: A Case Study
Authors: Kilaberia Tina , Stum Marlene 
Published: December 2020

Abstract
Effective interventions are needed to address elder family financial exploitation (EFFE), one of the most prevalent types of elder abuse globally. This poster examines the unique and critical help-seeking role informal family support can play when faced with EFFE. We present a holistic case study that offers an understanding of one family’s successful help-seeking and resolution of the EFFE situation. The family drew on internal family and community supports and did not seek formal elder abuse services. The case stood out as unique relative to 23 family’s help-seeking attempts in a larger study of the meaning and experience of EFFE from the perspective of concerned family members (non-abusing/non-victims). The case summary and analysis are based on an in-depth interview narrative reflecting the subjective experience of a concerned family member who was directly involved in the EFFE situation (in-law relative to both the older victim and the perpetrator). Study findings reveal 5 interwoven themes related to help-seeking processes and outcomes: 1) honoring the victim’s wishes, 2) providing support and accountability for perpetrator, 3) restoring family relationships and functioning, 4) maintaining internal (family-based) control, and 5) engaging in family problem solving processes. The family’s help-seeking demonstrated three distinctive features: a) embracing their informal social support role, b) the interdependence of family members, and c) restorative justice principles. The findings raise questions about broadening the scope and continuum of EFFE intervention research and practices to recognize and support informal social intervention.
Trajectory of Depression among Victims of Elder Mistreatment
Authors: Dong Gabriella , Li Mengting 
Published: December 2020

Abstract
Individuals exposed to elder mistreatment are affected in dissimilar ways. Most existing studies are cross-sectional and fail to capture the change in mental health of older adults with exposure to elder mistreatment. This study aims to examine depression trajectories of elder mistreatment victims and identify protective factors. Data were drawn from the two-wave Population Study of Chinese Elderly in Chicago (PINE) with 725 participants who reported elder mistreatment at the baseline. Depression was measured by Patient Health Questionnaire-9. Self-mastery was assessed by the Pearlin Mastery Scale. Conscientiousness was evaluated by the NEO Five-Factor Inventory. Multinomial logistic regression was used while controlling demographic factors and recurrence of elder mistreatment. We identified four depression trajectories among elder mistreatment victims: chronic (9.61%), delayed (6.27%), recovery resilience (21.17%), and resistance resilience (62.95%). The chronic group was showing severe depression in both waves. The delayed group experienced a delayed reaction with increasing depression over time. The depression level of the recovery resilience group bounced back from elder mistreatment. The resistance resilience group exhibited low depression over time. Elder mistreatment victims with increasing self-mastery were more likely to be in recovery resilience group than in chronic group (RRR=1.05, 95%CI=1.02-1.09). In addition, elder mistreatment victims with increasing conscientiousness were less likely to be in delayed group than in resistance resilience group (RRR=0.96, 95%CI=0.92-1.00). Healthcare providers and social service agents could focus on elder mistreatment victims with chronic and delayed depression trajectories. Interventions could promote mental health of elder mistreatment victims through improving self-mastery and conscientiousness.
CAPABLE Transitions: A Home Health Agency-Based Intervention to Optimize the SNF-to-Home Transition
Authors: Missell Rachel , Szanton Sarah , Caprio Thomas , Nathan Kobi , Simning Adam 
Published: December 2020

Abstract
Community Aging in Place-Advancing Better Living for Elders (CAPABLE) consists of an interprofessional team of a registered nurse (RN), occupational therapist (OT), and handyworker that delivers an in-home client-specific package of interventions to optimize function. CAPABLE aims to reduce functional impairment, home hazards, and acute medical services use and is being widely disseminated. To expand CAPABLE to older adults transitioning from the skilled nursing facility (SNF) to home, we developed CAPABLE Transitions, which makes several important modifications to CAPABLE. First, CAPABLE Transitions will be implemented within a Medicare-certified home health agency (CHHA) and delivered to CHHA clients. Second, it will be delivered to CHHA clients with and without dementia. Adding urgency to CAPABLE Transitions’ development, including persons with dementia has the potential to decrease high utilization of services and meet care transition needs. Third, it includes an initial RN care transition visit. Fourth, its services are more intensely delivered at the beginning of the intervention, shortly after SNF discharge. Beginning in the fall of 2020, CAPABLE Transitions will be tested in a feasibility study of 60 older adults discharged from post-acute SNF care to CHHA services in Rochester, NY. We have designed this 3-year feasibility study to consist of yearly recruitment waves that will enable us to iteratively assess and refine the intervention. Following this study, we hope to test CAPABLE Transitions’ effect on improving home time, quality of life, and the use of acute medical services in order to assist older adults in aging in place.
Race Differences and Depressive Symptoms Among Community-Dwelling Older Americans
Authors: Cheung Ethan Siu Leung , Mui Ada 
Published: December 2020

Abstract
Using data from the Wave 3 National Social Life, Health and Aging Project, this study examines cognition, stress and social support factors associated with depressive symptomatology among older White (n=2356) and Black/African Americans (n=473) living in the community. Bivariate analyses suggest that Whites were slightly older than Blacks [(M(SD) = 73 .24(8.18) and 72.52(8.69); 71)]; and had higher unmarried status (66.58% vs. 43.76%). In terms of cognitive functioning, Whites scored significantly higher than Blacks [Mean (SD) of MoCA Short Form were 10.44(3.06) and 7.75.0(3.33)]. There was race difference in depressive symptoms experienced (CESD Short Form: M(SD) = 20.99(4.01) for Whites; M(SD) = 21.35(4.33) for Blacks). In order to identify predictors of depression, multiple hierarchical regressions were performed. Results showed that race had significant independent effect and multiplicative effect with IADL impairment in explaining depression scores. To identify predicators for each racial group, parallel regression analyses were conducted and two models were significant. Findings show that unmarried status and IADL impairment were common predictors of depressive symptoms for the two groups, and the impact of both variables were stronger for Blacks (for unmarried status; b =-1.42 vs. -.52; for IADL impairment b = .23 vs. .13). For Whites, other unique predictors of depression were male gender, lower income, more ADL impairment, higher stress, less socialization and poor friendship quality. For Blacks, the only unique predictor of depressive symptoms was being younger age. The different correlates of depression for White and Black elders provide new insight into the design of race-sensitive interventions.
Systematic Review of Interventions for LatinX and American Indian Family Dyads Coping With Chronic Illness
Authors: McCarthy Michael , Sanchez Angelica , Garcia Yolanda Evie , Dunn Dorothy , Williamson Heather , Baldwin Julie , Hustead Morgan Lee-Regalado , Bakas Tamilyn 
Published: December 2020

Abstract
The United States is experiencing growth in populations from culturally diverse backgrounds. Studies suggest that Latinx and American Indians experience chronic conditions such as cancer, heart disease, and diabetes in greater numbers than whites. Literature also suggests that Latinx and American Indian families play a significant role as informal caregivers for loved ones with chronic illness. However, little information is available about interventions to assist these patient-family caregiver dyads cope. The purpose of this systematic review is to synthesize published studies about psychosocial interventions developed or adapted for Latinx and American Indian care dyads in order to determine: (1) the benefits of these interventions; (2) their distinguishing features or adaptations, and; (3) recommendations for future intervention development. The protocol for this review was registered in advance with the International Prospective Register of Systematic Reviews (PROSPERO). We searched the databases CINAHL, PsycINFO, MEDLINE, and PubMeb using MeSH-derived keywords developed in consultation with a research librarian. Studies were included/excluded based upon pre-specified criteria. Three-hundred thirty-five records were identified, screened by the research team, and tracked according to PRISMA guidelines. After removing duplicates (n=9), studies that did not pertain to the conditions of interest (n=13), and studies that did not meet inclusion criteria (n=305), eight studies remained. Relevant information was abstracted from the final studies and synthesized by the research team. The majority of interventions for these populations are in cancer. Findings about benefits are largely inconclusive. Adaptations include a focus on cultural contexts, as well as culturally-based strengths, caregiving norms, and values.
Pre-stroke dementia and in-hospital outcomes in the Chinese Stroke Center Alliance
Authors: Liu Chelsea , Gu Hong-Qiu , Yang Xin , Wang Chun-Juan , Yang Kai-Xuan , Li Zi-Xiao , Wang Yong-Jun 
Published: December 2020

Abstract
Little is known about the prevalence of pre-stroke dementia in China and whether this group is at higher risk of adverse in-hospital outcomes. We aimed to understand this association using data from the Chinese Stroke Center Alliance. Multivariable logistic regressions were conducted to assess the association between pre-stroke dementia status and ambulation at day 2, in-hospital mortality, and in-hospital complications. Covariates included age, sex, medical history, history of smoking, history of alcohol use, medication history (antiplatelet drugs, lipid-lowering drugs), stroke severity (measured by the National Institute of Health Stroke Scale), whether IV tPA was administered within 4.5 hours, and whether the patient received deep vein thrombosis prophylaxis as needed. Odds ratios and 95% confidence intervals were presented for the adjusted models. In the final analytic sample of 559,070 ischemic stroke patients with no prior stroke history enrolled across 1476 hospitals, 1511 (0.3%) had pre-stroke dementia, and they were older and more likely to be female. Patients with pre-stroke dementia had lower odds of ambulating at day 2, higher odds of having any complications and higher odds of in-hospital mortality compared to those without pre-stroke dementia, despite little difference in treatment received. Our findings may be explained by communication barriers experienced by patients with pre-stroke dementia that limited their ability to advocate for their own care needs. Further research is needed to determine whether a different care pathway or additional attention from clinicians is necessary for patients with pre-stroke dementia.
A robotic system for high-throughput automated lifespan and phenotyping analysis in C. elegans
Authors: Vayndorf Elena , Pitt Jason , Wu Judy , Chang Emily , Nguyen Richard , Liang Ashley , Ruan Renee , Kaeberlein Matt 
Published: December 2020

Abstract
A goal of gerontology-related research is to develop therapies to improve the healthy period of life by understanding and targeting the molecular hallmarks of biological aging. Much progress has been made toward understanding the genetic and biochemical nature of these hallmarks through studies using simple invertebrate model organisms, such as the nematode Caenorhabditis elegans. Over the past decade, the identification of potential genetic and pharmacological modifiers of lifespan and age-related pathologies in C. elegans and other model organisms has yielded fruitful leads for follow-up investigation. However, such studies are typically time- consuming and labor-intensive. The goal of our work is to automate tasks that require frequent, repeated observations and hours of manual labor to collect and analyze lifespan, motility, and other behavioral data in C. elegans and other nematode models. The advent of affordable high-quality digital cameras, robotics systems, and 3D printers, as well as the decreasing financial and computational costs of image storage and processing, have allowed us to automate data capture and analysis on a large scale. To this end, our group recently developed a tool, we call the WormBot, consisting of an unbiased, high-throughput, automated robotic system and corresponding software, to perform genetic and pharmacological quantification of lifespan and health measures in C. elegans and related nematode species. We will report updates recently made to this system, including significant improvements to hardware, and present screening results from proteasome stimulator drugs known to reduce the accumulation of proteotoxic proteins linked to neurodegenerative diseases and aging.
Racial/ethnic/gender-based Disparities in Health Trajectories among American Older Adults
Authors: Kong Dexia , Lu Peiyi , Davitt Joan , Shelley Mack 
Published: December 2020

Abstract
Numerous studies have examined racial/ethnic- or gender-based disparities in health. However, few examined health outcomes based on a combination of individuals’ race, ethnicity, and gender. Guided by an intersectionality framework, this study explores racial/ethnic/gender-based differences in older adults’ health trajectories over a ten-year period. Longitudinal data from the Health and Retirement Study (2004-2014) were used (n=16,654). Older adults (65+) were stratified into six groups based on their race, ethnicity, and gender, including (1) Non-Hispanic (NH) White Men; (2) NH White Women; (3) NH Black Men; (4) NH Black Women; (5) Hispanic Men; and (6) Hispanic Women. Growth curve models were used to examine the trajectories of three health indicators over time, including cognitive function, physical function (i.e. the sum of activities of daily living and instrumental activities of daily living), and depressive symptoms. The results indicated that NH White men and women outperformed racial/ethnic minority groups in cognition and physical function trajectories. Females in all racial/ethnic groups had more depressive symptoms but better cognition than their male counterparts. Hispanic women reported the most depressive symptoms. Hispanic women and NH Black women had the poorest physical function. NH Black men/women had the lowest cognition. Study findings highlighted the utility of an intersectionality framework in understanding health disparities in later life. Multiple social identities intersect with each other and generate protective and/or risk effects on cognitive, mental, and physical health status. Multilevel intervention strategies are warranted to close the health equity gap among various marginalized population groups.
Metabolomic Signatures of High Red Blood Cell Distribution Width
Authors: Corkum Abigail , Tian Qu , Ferrucci Luigi 
Published: December 2020

Abstract
Red blood cell distribution width (RDW) describes the amount of variation in blood cell volume and size and increases with age. Higher RDW predicts all-cause mortality, metabolic syndrome, diabetes, and markers of glycemic control, such as glycosylated hemoglobin. However, mechanisms that connect high RDW with these health outcomes are unknown. Thus, identification of high risk in these patients cannot be addressed. This study aims to identify metabolites and pathways that are associated with high levels of RDW in community-dwelling older adults. Using data from the Baltimore Longitudinal Study of Aging, we identified 1,004 cognitively normal participants (mean age: 67.1±13, 48% women, 26% black) with concurrent data on RDW and comprehensive targeted plasma metabolites by Biocrates p500. Participants were grouped into RDW quartiles (Q1:14%). Associations of metabolites with quartiles of RDW were examined using multivariable linear regression with Q1 being the reference group. Models were adjusted for age, sex, and race. Compared to Q1, Q4 had higher concentrations of SM(OH)C14:1, PC ae C30:2, and hypoxanthine, and lower concentrations of DHEAS, Cortisol, Tryptophan, and Hex2Cer(d/18:1/24:0) (all p&lt;0.01). These metabolites are critical components of sphingolipid metabolism and steroid hormone biosynthesis pathways. Elevated RDW was associated with metabolites derived from classes of hormones, amino acids, ceramides, sphingomyelins, PCs, and nucleobases. Individuals with elevated RDW (i.e. ≥14%) may have disrupted sphingolipid metabolism and steroid hormone biosynthesis. These pathways can be targeted for prevention.
Minority status and readmissions: a moderated mediation model of caregivers’ health literacy
Authors: Rayan-Gharra Nosaiba , Gur-Yaish Nurit , Shulyaev Ksenya 
Published: December 2020

Abstract
Family caregivers help patients to understand informa¬tion during clinical encounters. Less is known about factors that may affect family caregiver’s Ensuring and Explaining Medical Care (EEMC) during hospitalization and its impact on improved health outcomes. This study examined whether EEMC during hospitalization mediated the association between minority status of patients and 30-day-readmissions, and whether levels of Health Literacy (HL) of caregivers moderated this mediated association. A prospective cohort study of 517 internal medicine patients, Hebrew (general population, coded as 0) and Russian, or Arabic native speakers (minority status, coded as 1), at a tertiary medical center in central Israel, who were accompanied by an informal caregiver. EEMC and HL were patients’ self-reported. 30-day-readmissions were retrieved from the healthcare organization. Logistic regression indicated that minority status was not associated with 30-day readmission when the mediator ICEEMC was not included (B=0.98; p&gt;0.05). However, moderated mediation analysis indicated significant direct (B=-1.08; p=0.003) and indirect effect of minority status on readmission through high ICEEMC during hospitalization among patients who had informal caregivers with high HL level (Mediated effect (ME)=−0.62; CI= -1.07 to -0.29) but not among ones with low HL level (ME= 0.37; CI=-0.24 to 1.06). These findings suggest that caregivers’ high HL may be an essential factor in improving EEMC among minorities. Identifying informal caregivers with high HL level at time of admission to the hospital, and encouraging their involvement during patients’ hospital stay, might be a useful strategy to improve transitions and reducing 30-day readmission, especially among minority patients.
Associations Between Depressive Symptoms, Appetite and Food Intake Among Hospitalized Older Adults
Authors: Rogozinski Amos , Zisberg Anna 
Published: December 2020

Abstract
Inadequate food intake is common among hospitalized older adults and is linked to negative hospitalization outcomes, including functional decline and mortality. Depression is a well-established risk factor in inadequate food intake in the community but its role in food consumption during hospitalization is poorly studied. To examine the associations between depressive symptoms, appetite and the quantity of food consumed by older inpatients, we conducted a secondary data analysis of 724 hospitalized adults aged 69 to 95 using a prospective cohort dataset: Hospitalization Process Effects on Functional Outcomes and Recovery. Depression was evaluated with Tucker’s Short Zung Instrument at time of admission. Food intake and appetite were examined daily for three consecutive days, using self-reports of food consumed at breakfast, lunch and supper, based on the nDay Express Questionnaire. Approximately 40% of respondents reported eating half or less than half of each meal. The risk of depression was prevalent among a third of respondents, 54% of whom were identified at high risk of depression. The association between depression and inadequate food intake was found to be negative [F(2,716)=9.00 ,p=0.000 ,η2=0.025]. Low appetite was significantly linked to reduced food consumption [β=-0.39, t=-12.06, p=0.000] and made a considerable contribution to the explained variance of food consumed [F-change (1,717)=145.41 , p=0.000]. Finally, decreased appetite partially mediated the association between depressive symptoms and food intake during hospitalization (B=-0.001, UCI=-0.001; LCI=-0.002). These findings contribute to the understanding of inadequate food intake during hospitalization and indicate the importance of screening for depression among hospitalized older adults.