bluuebunny/crossref_metadata_2025_split huggingface dataset:
Online health information seeking behaviours of parents of children undergoing surgery in a pediatric hospital in Rome, Italy: a survey
Authors: Russo Luisa , Campagna Ilaria , Ferretti Beatrice , Pandolfi Elisabetta , Atti Marta Luisa Ciofi Degli , Piga Simone , Jackson Sally , Rizzo Caterina , Gesualdo Francesco , Tozzi Alberto Eugenio 
Published: July 2020

Abstract
Background: People increasingly search online for health information. Particularly, parents of patients often use the Internet as a source for health information. We conducted a survey to investigate the online searching behavior of parents of patients <18 years, admitted for surgery in an Italian pediatric hospital.
Methods: The cross-sectional survey was nested in a prospective cohort study on surgical procedures. Parents of patients undergoing surgical procedures at Bambino Gesù Children's Hospital, Rome, Italy, were enrolled and contacted by phone after the procedure. We recorded socio-demographic data, sex, length of stay following surgery, proximity of residence to the hospital, use of the internet to search for information on the surgery before and after the intervention and effect of information found online.
Results: The majority (91%) of parents of children undergoing surgical intervention used the internet. Of these, 74.3% of parents searched for information before surgery, and 26.1% searched for information after. Most parents searched for information on the care provider’s website. Two thirds of parents reported that information found online had increased their understanding of the child’s condition. Multivariate analyses indicated that families living far from the hospital (> 43 km) were more likely to search for health information (OR 2.3; 95% CI 1.34 - 4.00), as were families of patients undergoing a major surgery (OR=2.1; 95% CI 1.04 - 4.11).
Conclusions: Parents of children undergoing surgery often search online for information on their child’s intervention, in particular those whose child is scheduled for a major surgery and those living far from the hospital. A survey like the present one allows to understand parents’ information needs, to better guide them in online information seeking and to better tailor information provided on the care provider’s website.
Clinical heterogeneity and novel pathogenic variants of Chinese patients with neuroacanthocytosis
Authors: Yu Hao , Zhang Liang , Li Xiao-Yan , Wu Zhi-Ying 
Published: July 2020

Abstract
Background: Neuroacanthocytosis (NA) syndromes are a group of exceedingly rare diseases, including McLeod syndrome (MLS) and chorea-acanthocytosis (ChAc). The characteristic phenotypes comprise a variety of movement disorders, including chorea, dystonia, and parkinsonism. We aimed to investigate the clinical heterogeneity and novel pathogenic variants of Chinese patients with neuroacanthocytosis.Results: Three novel XK variants (c.942G>A, c.970A>T, c.422_423del) were identified in three index MLS patients and three novel VPS13A variants (c.3817C>T, c.9219C>A, c.3467T>A) in two index ChAc patients. In addition, we summarized the genotypes and phenotypes of reported MLA patients and ChAc patients in the Chinese population.Conclusion: Our study expands the genetic spectrum of XK and VPS13A and helps the clinical diagnosis of neuroacanthocytosis.
Imported Mansonella perstans infection in Spain.
Authors: Puente Sabino , Lago Mar , Subirats Mercedes , Sanz-Esteban Ismael , Arsuaga Marta , Vicente Belen , Alonso-Sardon Montserrat , Belhassen-Garcia Moncef , Muro Antonio 
Published: July 2020

Abstract
Background: Mansonella perstans infection can be considered one of the most neglected tropical infectious diseases. Very few studies have reported on the clinical picture caused by infection with this nematode. Therefore, our study was aimed to describe the clinical patterns and treatment of imported M. perstans infection by migrants from Africa.Methods: The present study evaluated a large cohort of migrants who have been diagnosed, examined and treated for imported M. perstans infection at a Spanish reference center (Hospital Carlos III Tropical Medicine Unit, Madrid, Spain) over a 19-year period. Most patients voluntarily attend the emergency unit or are referred from primary care or general hospitals in Madrid. Categorical variable results were expressed as percentages and as the mean and standard deviation (SD) for continuous variables. Chi-square test was used to compare the association between the categorical variables. The measured outcomes were expressed as the odds ratio (OR) with a 95% CI. The continuous variables were compared by Student’s t-test or the Mann–Whitney test. The corresponding regression models were used for multivariate analysis. Results: Five hundred three cases of migrants from tropical and subtropical areas with M. perstans infection were identified. Two hundred sixty-four patients were female (52.5%). The mean age (±SD) was 44.6±18.2 years (range, 16–93 years). The mean time (±SD) between the arrival in Spain and the first consultation was 8.6±18.0 months. The origin of the patients was Equatorial Guinea (97.6%). Regarding the clinical picture, 257 patients were asymptomatic (54.7%) and 228 were symptomatic (45.3%); 190 patients had pruritus (37.8%), 50 (9.9%) had arthralgia, 18 patients had Calabar-like swelling (3.6%), and 15 (3%) had abdominal pain. Four hundred forty-two (87.9%) migrants had hyper-IgE, and 340 (67.6%) had eosinophilia. One hundred ninety-five patients had coinfections with other filarial nematodes (38.8%), and 308 migrants had only M. perstans infection (61.2%). Four hundred thirty-seven cases (86.9%) had been treated with anti-filarial drugs: 292 cases were treated with one anti-filarial drug, and 145 cases were treated with combined anti-filarial therapy. Additionally, 20 (4%) cases received steroids and 38 (7.6%) cases received antihistamines. Conclusions: A long series of M. perstans infections is presented in sub-Saharan immigrants whose data indicate that it should be included in the differential diagnosis in patients with pruritus or analytical alterations such as eosinophilia or hyper-IgE presentation, and they also have a high number of coinfections with other microorganisms whose treatment needs to be protocolized.
Sexual health status and vitamin D in primary care patients from the Middle East and Sweden
Authors: Taloyan Marina , Steiner Kristin , Östenson Claes-Göran , Salminen Helena 
Published: July 2020

Abstract
Background

Low vitamin D is more common in Middle Eastern-born patients (Middle Easterners) than in Swedish-born patients of northern European descent (Swedes), and the condition might affect sexual health. The present study (i) investigated primary care (PC) patients (ii) compared self-reported sexual health in Swedes and Middle Easterners; (iii) analysed differences within and between the groups and (iv) analysed differences in vitamin D levels between the groups.
Methods

522 PC patients responded to a health questionnaire that included items on sexual health. All provided blood samples: 225 Middle Easterners from Iran, Iraq, and Turkey and 297 Swedes. Logistic regression was used to calculate the odds ratio (OR).
Results

Middle Easterners reported less sexual dysfunction than Swedes; 75.8% of Middle Easterners and 18.9% of Swedes presented a 25(OH)D of < 50 nmol/L. The crude OR for reporting sexual dysfunction was 70% higher in Swedes compared to Middle Easterners (OR 1.50, 95% CI 0.92–3.23). This OR remained significant after adjustment for age, gender, waist circumference, and reported sexual desire. But the significance disappeared after additional adjustment for vitamin D. In both groups, more females than males reported insufficient sexual desire. More female Middle Easterners reported sex life dissatisfaction. More female Swedes reported sexual dysfunction. Covariate inclusions could not explain the association between gender and insufficient sexual desire. Vitamin D could explain association between gender and sex life dissatisfaction in Middle Easterners, and age could explain association between gender and sexual dysfunction in Swedes. Age, waist circumference, and vitamin D levels were significant covariates in the logistic regression models.
Conclusions

Results from the present study suggest that vitamin D variation partly explains differences in sexual dysfunction between the groups and between genders within the groups. Vitamin D therapy should be investigated to determine if these results are clinically useful. That said, perceptions about sex life and mental health (rather the physiological pathology) might explain the results. And further investigation into female Middle Easterners and female Swedes is warranted.
Transmission Potential and Forecasting The Number of Coronavirus Disease 2019 in Hubei Province, China
Authors: Wang Ke-wei , Gao Jie , Wang Hua , Wu Xiao-long , Yuan Qin-fang , Cheng Yang 
Published: July 2020

Abstract
Background: Coronavirus disease 2019 (COVID-19) was first reported in Wuhan, Hubei province, China. We aimed to describe the temporal and spatial distribution and the transmission dynamics of COVID-19 and to assess whether a hybrid model can forecast the trend of COVID-19 in Hubei Province, China. Method: The data of COVID-19 cases were obtained from the websites of Chinese Center for Disease Control and Prevention, whereas the data on the resident population were obtained from the websites of Hubei Provincial Bureau of Statistics. The temporal and spatial distribution and the transmission dynamics of COVID-19 were described. A combination of autoregressive integrated moving average (ARIMA) and support vector machine was constructed to forecast the trend of COVID-19. Results: A total of 56,062 confirmed COVID-19 cases, which were mainly concentrated in Wuhan, were reported from January 16 to March 16, 2020 in Hubei Province, China. The daily number of confirmed cases exponentially increased to 3,156 before February 4, 2020, fluctuated to 4,823 before February 13, 2020, and then markedly decreased to 1 after March 16, 2020. The highest mean reproduction number R(t) of 9.48 was recorded on January 16, 2020, after which it decreased to 2.15 on February 2, 2020 and further decreased to less than 1 on February 13, 2020. In the modeling stage, the mean square error, mean absolute error, and mean absolute percentage error of the hybrid ARIMA–SVM model decreased by 98.59%, 89.19% and 89.68%, and those of SVM decreased by 98.58%, 87.71%, and 88.94%, respectively, compared with the ARIMA model. Similar results were obtained in the forecasting stage.Conclusion: Public health interventions resulted in the terminal phase of COVID-19 in Hubei province. The hybrid ARIMA–SVM model may be a reliable tool for forecasting the trend of the COVID-19 epidemic.
Observation of strong excitonic magneto-chiral anisotropy in twisted bilayer van der Waals crystals
Authors: Lan Shoufeng , Liu Xiaoze , Wang Siqi , Zhu Hanyu , Liu Yawen , Gong Cheng , Yang Sui , Shi Jing , Wang Yuan , Zhang Xiang 
Published: July 2020

Abstract
The interplay between chirality and magnetism generates a distinct physical process, the magneto-chiral effect, which enables one to develop functionalities that cannot be achieved solely by any of the two. Such a process is universal with the breaking of parity-inversion and time-reversal symmetry simultaneously. However, the magneto-chiral effect observed so far is weak when the matter responds to photons, electrons, or phonons. Here we report the first observation of strong magneto-chiral response to excitons in a twisted bilayer tungsten disulfide with the amplitude of excitonic magneto-chiral (ExMCh) anisotropy reaches a value of ~4%. We further found the ExMCh anisotropy features with a spectral splitting of ~7 nm, precisely the full-width at half maximum of the excitonic chirality spectrum. Without an externally applied strong magnetic field, the observed ExMCh effect with a spontaneous magnetic moment from the ferromagnetic substrate of thulium iron garnet at room temperature is favorable for device applications. The unique ExMCh processes provide a new pathway to actively control magneto-chiral applications in photochemical reactions, asymmetric synthesis, and drug delivery.
Imaging Features of Hepatocellular Carcinoma with Bile Duct Tumor Thrombus: A Multicenter Study
Authors: Huang Li-Ming , Wu Jun-Yi , Bai Yan-Nan , Wu Jia-Yi , Wei Yong-Gang , Zhang Zhi-Bo , Yan Mao-Lin 
Published: July 2020

Abstract
Background: There are still difficult and challenging problems in diagnosis of hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) before operation. This study aimed to analyze the imaging features of HCC with B1-B3 BDTT. Methods: The clinicopathological data and imaging findings of 30 HCC patients with B1-B3 BDTT from three high-volume institutions were retrospectively reviewed. Eighteen patients underwent computed tomography (CT) scans and twelve patients underwent magnetic resonance imaging (MRI) scans before operation, respectively. The diagnosis of HCC with BDTT was conﬁrmed by postoperative pathologic examination.Results: According to Japanese classification, 5 patients were classified as B1 BDTT, 12 B2, 13 B3, and 82 B4, respectively. The HCC lesions were detected in all patients, and the localized bile duct dilation were detected in 28 (93.3%) patients. The BDTT was observed in all B3 patients and 3 B2 patients, but it was not observed in all B1 patients on CT or MRI. The BDTT showed relatively hypoattenuation on plain CT scans and T1W images, relatively hyperattenuation signals on T2W. The BDTT showed hyperattenuation at hepatic arterial phase with washout at portal venous phase. The localized biliary dilation showed no enhancement at hepatic arterial phase and no progressively delayed enhancement at portal venous phase, but it was more obvious at portal venous phase on CT.Conclusions: The HCC lesions and the localized bile duct dilatation on CT or MRI scans are imaging features of HCC with BDTT, which might facilitate the early diagnosis for B1-B3 BDTT.
A Reconfigurable Analog Back-End for CubeSat Communications
Authors: Alvarez-Flores José L. , Flores-Troncoso Jorge , Sandoval-Arechiga Remberto , Castillo Joel A. , Simon Jorge , Hernandez-Calviño Manuel , Soriano-Equigua Leonel 
Published: July 2020

Abstract
Current small satellite platforms such as CubeSats, require robust and versatile communication subsystems that allow the reconfiguration of the critical operation parameters such as carrier frequency, transmission power, bandwidth, or filter roll-off factor. In this paper, a reconfigurable Analog Back-End for CubeSat communications is proposed. This prototype is implemented using CAD software, on a 6-layer PCB of 10 cm^2 to implement a transceiver that operates from 0.070 to 6 GHz and complying with CubeSat and IPC-2221 standards. An Software-Defined Radio approach implemented on a baseband processor is used for control purposes. Measurements showed that the signal power at the output of the proposed analog back-end is suitable to feed the subsequent antenna subsystem.
Vitamin D Levels in Pregnant Congolese Women and Their New-Borns, and the Association with Neonatal Outcomes – A Pilot Study
Authors: Dhillon Gurpreet , Rai Sunil , Dhillon Harpreet , Sasidharan Shibu , Kimweri Costa , Shibu Babitha , Mbackѐ Mame Diarra , Singh Suneeta , Singh Vijay 
Published: July 2020

Abstract
Background: This study was thus undertaken to study the estimation of vitamin D levels in pregnant women and their newborns in DRC and to study its association with various neonatal outcomes. Methods: Observational study done on 569 pregnant women and their newborn babies. Sample obtained from maternal serum and cord blood from the placental end during peripartum period. The data was analysed to estimate the prevalence of vitamin D levels in mothers and newborns and to identify association, if any, between maternal vitamin D levels and neonatal outcomes.Results: 464 mothers had sufficient vitamin D (VDS) levels (>30 ng/dL) and 105 had vitamin D deficiency (VDD) with mean maternal serum vitamin D level of 35.63ng/ml (SD 6.18, range 9.2-39.8). All the newborns (n=569) were vitamin D deficient (<30ng/ml). The percentage of LBW babies born to VDD mothers was 18.09%, which was very similar to the percentage of LBW babies born to VDS mothers (18.31%) (p=0.76456749). The incidence of caesarean section was 58.09% in the vitamin D deficient (VDD) group as compared to 19.61% in the sufficient (VDS) group (p<0.0005). The incidence of preterm births was 10.77% in the sufficient group (VDS) as compared to 17.14% in the vitamin D deficient (VDD) group (p=0.038). Conclusion: Our findings will help health professionals, policy makers, and the general public in Africa aware of the high prevalence of vitamin D deficiency and the associated health risks.
The Effectiveness of Laid-back Position on Lactation Related Nipple problems and comfort: A meta-analysis
Authors: WANG Zhi , LIU Qiuyue , MIN Lihua , MAO Xiaorong 
Published: July 2020

Abstract
Background The importance of breastfeeding for maternal and child health has become an international consensus. However, it has been found that lactation-related nipple problems are common and there are some important factors affecting the effectiveness of breastfeeding. Multiple studies recommended the laid-back breastfeeding, but the researches are on various levels of quality and the results are controversial.Methods We systematically searched the following twelve databases: Cochrane Library, EMBASE, Medline, Ovid, PubMed, Web of Science, CINAHL, Scopus, SinoMed, Chinese National Knowledge Infrastructure (CNKI), WanFang, and VIP from inception to January 28,2020. All studies reporting the laid-back breastfeeding or biological nurturing were considered, regardless of they are randomized controlled trials. Two trained investigators independently evaluated the quality of the included the articles and screened the data. All the data were analyzed separately using Review Manager Version 5.3 and STATA/SE Version 15.1. Results A total of 12 studies involving 1,936 groups of postpartum women and their newborns were included. The results of meta-analysis showed that nipple trauma (RR = 0.47; 95% CI 0.29,0.75; p < 0.002), nipple pain (RR = 0.25; 95% CI 0.20,0.32; p < 0.00001), the correct posture of latching (RR = 1.22; 95% CI 1.11,1.33; p < 0.00001)and position comfort (ES = 0.01; 95%CI -0.28,0.30; p = 0.006) of experimental group were all better than control group, and the differences were statistically significant ( p < 0.05), which indicates that the laid-back position has a positive effect on maternal breastfeeding. Conclusion Laid-back position has significant advantages in decreasing the incidence of nipple trauma and nipple pain compared with traditional breastfeeding postures, and it appears that laid-back position is conducive to the correct posture of latching. However, current evidence does not show different breastfeeding outcomes in the two groups of position comfort. Laid-back position is helpful to solve lactation-related nipple problems and it can be used as a recommended position for breastfeeding. Key words: Breast-feeding, Biological Nurturing, Laid-back Breastfeeding, Meta-Analysis
Endothelial Cells Promote Docetaxel Resistance of Prostate Cancer via FGF2/ERG/Akt/mTOR Signaling Pathway
Authors: Zhou Wen-Hao , Su Yi-Ming , Zhang Yu , Han Bang-Min , Liu Hai-Tao , Wang Xiao-Hai 
Published: July 2020

Abstract
Background

Docetaxel is a first-line chemotherapy for the treatment of patients with castration-resistant prostate cancer (CRPC). Despite the good initial response of docetaxel, drug resistance will inevitably occur. Mechanisms underlying docetaxel resistance are not well elaborated. Endothelial cells (ECs) have been implicated in the progression and metastasis of prostate cancer (PCa). However, little attention has been paid to the role of ECs in the development of docetaxel resistance in PCa.
Methods

Here, we sought to investigate the function and mechanism of ECs involving in the docetaxel resistance of PCa. The 22Rv1 and C4-2B PCa cell lines were cultured with or without human umbilical vein endothelial cells (HUVEC). The proliferation of each PCa cell line was assessed by CCK8 and EdU assays. Cell viability of each PCa cell line treated with docetaxel was evaluated by CCK8. Apoptosis was measured by flow cytometry. Quantitative reverse transcription (RT)-PCR assay was used to determine the expression of ETS related gene (ERG) in each PCa cell line and FGF2 in HUVEC. The proteins including ERG, Caspase3, PARP, Akt, p-Akt, mTOR and p-mTOR were quantified by western blotting. ERG overexpressing C4-2B cells(C4-2B-ERG) were constructed by transfection with pLenti6.3-ERG lentivirus. C4-2B-ERG cells were knocked down by transfecting with ERG siRNAs. Differentially expressed cytokines between the serum-free media from 22Rv1 and 22Rv1/HUVEC co-culture system were detected by human cytokine array and determined by ELISA assay. Tumors were induced in mice by injecting 22Rv1 cells with or without HUVEC and treated with docetaxel. Tumor growth and apoptosis were examined by immunohistochemistry and TUNEL respectively.
Results

ECs promoted proliferation and inhibited apoptosis in PCa cells (in vitro) and mouse xenograft tumors induced by these cells (in vivo) under docetaxel treatment. ECs secreted FGF2 to induce ERG expression and activate the Akt/mTOR signaling pathway in PCa cells contributing to docetaxel resistance. Blocking FGF2 could reverse the enhancing effects of HUVEC on docetaxel resistance in PCa cells. Inhibition of the Akt/mTOR signaling pathway could alleviate chemoresistance mediated by ERG.
Conclusion

ECs promote docetaxel resistance via FGF2/ERG/Akt/mTOR signaling pathway in PCa cells. Targeting FGF/ FGFR signaling may represent a promising therapeutic strategy to overcome docetaxel resistance.
The COX10-AS1/miR-641/E2F6 feedback loop is involved in the progression of glioma
Authors: Liu Liang , Li Xiaojian , Wu Heming , Tang Yong , Li Xiang , Shi Yan 
Published: July 2020

Abstract
Background

Glioma is the most common primary tumour of the central nervous system and is considered one of the greatest challenges for neurosurgery. Mounting evidence has shown that lncRNAs participate in various biological processes of tumours, including glioma. This study aimed to reveal the role and relevant mechanism of COX10-AS1 in glioma.
Methods

The expression of COX10-AS1, miR-641 and E2F6 was measured by qRT-PCR and/or western blot. Clone formation assays, EdU assays, Transwell assays and tumour xenograft experiments were performed to evaluate the effects of COX10-AS1, miR-641 and E2F6 on glioma proliferation, migration and invasion. Luciferase reporter assays, RNA pull-down assays and ChIP assays were conducted to analyse the relationship among COX10-AS1, miR-641 and E2F6.
Results

First, we demonstrated that COX10-AS1 was upregulated in glioma tissues and cell lines, which was related to the grade of glioma and patient survival. Next, through functional assays, we found that COX10-AS1 influenced the proliferation, migration and invasion of glioma cell lines. Then, with the help of bioinformatics analysis, we confirmed that COX10-AS1 regulated glioma by acting as a sponge of miR-641 to regulate E2F6. Moreover, further study indicated that E2F6 could promote COX10-AS1 expression by binding to its promoter region.
Conclusions

COX10-AS1 acts as an oncogene in combination with COX10-AS1/miR-641/E2F6 in glioma, which may be beneficial to the diagnosis and treatment of glioma.