bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relationship Between Medicaid Coverage and Outcomes Following Total Knee Arthroplasty
Authors: Lakomkin Nikita , Hutzler Lorraine , Bosco Joseph A. 
Published: April 2020

Background:
Access to elective total knee arthroplasty is important in the treatment of end-stage arthritis, and numerous initiatives, including Medicaid expansion, have sought to improve patients’ ability to undergo this procedure. However, despite this, the role of Medicaid insurance in patient outcomes remains unclear. The purpose of this study was to perform a systematic review of the literature to explore the relationship between preoperative Medicaid insurance status and outcomes following primary total knee arthroplasty.

Methods:
A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to identify studies examining outcomes in patients who had Medicaid and were undergoing total knee arthroplasty. Studies including complex revision operations or less common indications for total knee arthroplasty were excluded. Data on insurance status, postoperative complications, length of stay, readmissions, and subsequent revision surgical procedures were collected for each article.

Results:
A total of 13 studies showing 6.18 million patients undergoing total knee arthroplasty were included in the qualitative synthesis. Seven analyses described an important association between Medicaid coverage and short-term readmissions, and 2 analyses showed a relationship between Medicaid and prolonged length of stay. However, the included studies did not describe a significant association between Medicaid and postoperative mortality or revision rates.

Conclusions:
Patients with Medicaid undergoing total knee arthroplasty may be more likely to experience an increased length of stay and to be readmitted postoperatively. The unique factors associated with these patients may help to inform customized perioperative surveillance and optimization to improve outcomes in this group.

Level of Evidence:
Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Acetabular Component Migration Measured Using Radiostereometric Analysis Following Revision Total Hip Arthroplasty
Authors: Abrahams John M. , Callary Stuart A. , Munn Zachary , Jang Sung Won , Huang Qiang , Howie Donald W. , Solomon Lucian Bogdan 
Published: April 2020

» Radiostereometric analysis (RSA) studies of acetabular component migration following revision total hip arthroplasty (THA) have a large variation in their methodology and reporting of results, and, therefore, they may not be directly comparable. Standardization of RSA reporting is recommended.» In our review of RSA studies, there was a trend for cemented acetabular components to have larger amounts of early proximal migration than uncemented acetabular components. Results regarding cemented and uncemented components should be reported separately.» Cohorts that addressed larger acetabular defects were associated with a larger amount of early migration.» Reporting the migration result at 1 and 2 years postoperatively may enable earlier identification of poorly performing implants.
Effect of Cellgevity® Supplement on Selected Rat Liver Cytochrome P450 Enzyme Activity and Pharmacokinetic Parameters of Carbamazepine
Authors: Amponsah Seth Kwabena , Nguessan Benoit Banga , Akandawen Martin , Aning Abigail , Agboli Sedem Yawa , Danso Eunice Ampem , Opuni Kwabena Frimpong-Manso , Asiedu-Gyekye Isaac Julius , Appiah-Opong Regina 
Published: April 2020

Abstract
Background: There is considerable evidence that many patients concurrently administer dietary supplements with conventional drugs, creating a risk for potential drug-supplement interaction. The aim of this study was to determine the effect of Cellgevity® supplement on selected rat liver cytochrome P450 (CYP) enzymes. Also, we sought to deternine the effect of Cellgevity® on the pharmacokinetics of carbamazepine, a CYP3A4 substrate. Methods: Male Sprague-Dawley (SD) rats were randomly put into 5 groups and administered (per os) either distilled water (negative control), Cellgevity® (3 separate doses) or phenobarbital (positive control). Modulation of liver CYP enzyme activity was evaluated after 30 days of treatment, using probe substrates, spectroscopic and high-performance liquid chromatographic methods. In the pharmacokinetic study, 12 SD rats were divided into 2 groups administered (per os) carbamazepine plus Cellgevity®, or carbamazepine plus normal saline, both over a period of 14 days. Blood samples from rats in the same group were collected after treatment. Serum samples were prepared and pooled together at each specific sampling time point. Levels of carbamazepine were determined using a fluorescence polarization immunoassay. Results: Activities of rat liver CYP1A1/2, CYP2C9 and CYP2D6 were significantly increased by Cellgevity® after 30-day treament. Pharmacokinetic parameters for rats administered carbamazepine with Cellgevity® vis-a-vis carbamazepine with normal saline were as follows: Cmax; 20 μmol/L vs 11 μmol/L, AUC0→24; 347 μmol.h/L vs 170 μmol.h/L, Ke; 0.28 h-1 vs 0.41 h-1, and t1/2; 2.3 h vs 1.7 h, respectively.Conclusions: Cellgevity® increased the activity of rat CYP1A1/2, CYP2C9 and CYP2D6 enzymes, and altered the pharmacokinetics of carbamazepine in rats.
The impact of having a baby with cleft lip and palate on parents and on parent-baby relationship: the first French prospective multicentre study
Authors: GROLLEMUND BRUNO , Dissaux Caroline , Gavelle Pascale , Martinez Carla Perez , Mullaert Jimmy , Alfaiate Toni , Guedeney Antoine 
Published: April 2020

Abstract
Background : The objective of this prospective, multidisciplinary and multicenter study was to explore the effect of a cleft lip, associated or not with a cleft palate, on parents, on parent-infant relationship, and on the baby’s relational development. It also highlighted how the type of cleft and the timing of the surgery could impact this effect. Method : 158 infants, with Cleft lip with or without Palate, and their parents participated in this multicenter prospective cohort. Clinical evaluations were performed at 4 and 12 months postpartum. The impact on the parents and on the parent-infant relationship was evaluated by the Parenting Stress Index (PSI), the Edinburgh Post-partum Depression Scale (EPDS) and the Impact-on-Family Scale (IOFS). The relational development of the infant was assessed using the Alarm Distress Baby Scale (ADBB). The main criteria used to compare the infants were the severity of cleft and the time of surgery. Results The timing of surgery, the type of malformation or the care structure had no effect on social withdrawal behaviors of the child at 4 and 12 months postpartum (ADBB). Furthermore, early intervention significantly decreased maternal stress assessed with the PSI at 4 months. Parents for whom it had been possible to give a prenatal diagnosis were much better prepared to accept the waiting time between birth and the first surgical intervention (IOFS). Higher postpartum depression scores (EPDS) were found for both parents compared to the general population. Conclusion : A joint assessment of the mental health of both infants and parents is required in the follow-up of cleft lip and palate. Even if most families are remarkably resilient faced with this major cause of stress, a significant proportion of them could require help to deal with the situation, especially during this first year of follow-up. An assessment of the child’s social withdrawal behaviour and of the parental stress and depression appears useful, in order to adapt care to infant and parent’s needs. Trial Registration: ClinicalTrials.gov Identifier: NCT00993993. Registered 10/14/2009 < https://clinicaltrials.gov/ct2/show/NCT00993993?term=grollemund&draw=2&rank=1.
Safety and Efficacy of Hemispherical with Flattened Pole Dual-Mobility Acetabular Cup in Primary Hip Arthroplasty: The SYMCOR-1 study
Authors: Bonin Nicolas , Estour Gilles , Gedouin Jean-Emmanuel , Guyen Olivier , Daoud Frederic Christopher 
Published: April 2020

Abstract
Background: This study estimated the short-term clinical safety and efficacy of hemispherical with flattened pole cobalt-chromium metal-back with porous outer hydroxyapatite coating dual-mobility acetabular cup (HFPC-DM-HA) in primary total hip arthroplasty.Methods: Single-center retrospective observational cohort study of consecutive patients undergoing total hip arthroplasty with a HFPC-DM-HA 2 years prior to study start. Prospective 2-year follow-up with letter and phone questionnaires.Results: Sampling frame: 361 patients including 59 patients (16.3%) in the cohort. 6 patients (10%) lost to follow-up. Median age 77.5 years (range: 67 ; 92), 32% female, median BMI 25.2 kg.m-2 (18.4 to 56.8). Clinical indications: Primary THA in all patients, resulting from primary osteoarthritis in 80% of them. Median follow-up 3.0 years (2.7 to 4.1). Primary endpoint: 2-year implant survival rate: 97% [87, 99]. Prosthetic dislocation: 0%. Secondary endpoint: Modified HHS (pain & functional subscore) improved from baseline 39.7 [34.6, 44.7] to 75.8 [72.1, 79.6] at 1-year and to 86.7 [83.7, 89.7] at 2-year follow-up (p<0.0001).Conclusions: The authors deemed the short-term outcomes of this acetabular cup in primary total hip arthroplasty to be satisfactory.Study registration: clinicaltrials.gov NCT04209374.
H.Pylori Infection Induces CXCL8 Expression and Promotes Gastric Cancer Progress Through Downregulating KLF4
Authors: liu zhengxia , Wu Xiao , Tian Yuanyuan , zhang wanchun , qiao siyuan , xu wenting , liu yakun , Wang Siying 
Published: April 2020

Abstract
Background Tumour-derived CXCL8 facilitates the movement of myeloid-derived suppressor cells (MDSCs), which have the capacity to restrain antitumour immune responses, into the tumour microenvironment. Kruppel-like factor 4 (KLF4) is a potential tumour suppressor in gastric cancer (GC). However, little is known about the correlation between KLF4 and CXCL8 in gastric carcinoma.Methods In this study, we used cellular and molecular biological methods to assess whether these two factors interact in GC.Results We found that the expression levels of CXCL8 and KLF4 were altered in human GC tissues compared to normal gastric tissues in opposite ways. In addition, we found that CagA gene transduction or Helicobacter pylori infection resulted in the upregulation of CXCL8 expression. Knockdown of KLF4 expression increased CXCL8 expression at the protein and RNA levels, whereas overexpression of KLF4 had the opposite effect. Further mechanistic research revealed that KLF4 binds the CXCL8 promoter and negatively regulates CXCL8 at the transcriptional level. Moreover, CXCL8 factor stimulation reduced KLF4 expression, and the CXCL8-mediated increase in GC cell migration and proliferation was reversed by the upregulation of KLF4 expression, eventually promoting neoplasm growth in vivo.Conclusions Taken together, our findings demonstrate that CXCL8 is a decisive downstream target gene of KLF4 in gastric carcinoma. Targeted KLF4 activation could improve the immunosuppressive microenvironment through direct, negative regulation of CXCL8, providing a new potential target to strengthen the efficacy of immunotherapy in patients with GC.
An Inter-Method Reliability Study Comparing Interview Information on Sunlight, Tanning Beds, Food, and Supplement Exposures with Serum 25-Hydroxy Vitamin D Levels
Authors: Cook Linda S. , Li Xichen , Grevers Xin , Pestak Claire R. , Brockton Nigel , Le Nhu , Luo Li 
Published: April 2020

Abstract
Background: We developed a questionnaire designed to capture the vitamin D related exposures of sunlight, tanning bed use, dietary intake, and supplement use, and used an inter-method reliability approach to compare the study method (self-reported information on vitamin D related exposures nearest the blood draw) with serum 25-hydroxy vitamin D (25(OH)D) levels. Methods: This inter-method reliability study included 512 control women from a population-based, case-control study in Alberta, Canada. All women self-reported data on food/supplement intake (average µg/day), sun exposure (cumulative hours/year), and tanning bed exposure (cumulative hours/year) and provided fasting serum samples, measured in duplicate with a DiaSorin immunoassay for 25(OH)D levels. The correlation between participant characteristics and 25(OH)D are described. We used multivariable robust regression to estimate the percent of variation in 25(OH)D explained by our variables of interest. Results: Food intake, sun exposure, and tanning bed exposure had positive and significant correlations with 25(OH)D levels of a similar magnitude (Spearman r= 0.17 to 0.19). Supplement intake (average µg/day, Spearman r= 0.44) had the strongest positive correlation. In both crude and adjusted models (adjusted for age, body mass index, race, smoking, oral contraceptive use, and menopausal status/hormone therapy), we consistently found that food explained 3.1%, supplements 18.9%, sunlight 2.2%, and tanning bed use 3.0% of the variation in 25(OH)D levels, and all variables combined explained 27.5% - 36.0% of the total variation. Conclusions: These results suggest that our comprehensive dietary and light exposure questionnaire may be a reasonable proxy measure of vitamin D status in the recent past when either 25(OH)D measurements or serum samples are not available for study participants.
Hyper-sphere support vector machine based on collaborative knowledge mining and SMO optimization in power load forecasting
Authors: PAN Resheng , Li Hui , WANG Zhidong , PENG Dong , ZHAO Lang , Wang Yongli , Li Fang 
Published: April 2020

Abstract
Background

Due to the influence of power market reform policies, the conversion of power loads has become more and more complicated. The current load forecasting methods have long calculation times and inaccurate volatility load forecasting. The difficulty of forecasting is becoming greater and more accurate. It becomes very important to predict the electrical load. Under this background, this paper proposes the application methods of collaborative knowledge mining and SMO in solving prediction models based on hyperball support vector machine (CKM / SMO-SVM).
Methods

This study first analyzes the impact of historical data on samples and different parameters. The prediction of power load, sample data and various parameters have a significant impact on the prediction results. Secondly, applying weak entropy theory for collaborative knowledge mining, preprocessing sample data and historical information. Third, a short-term power load forecasting system based on the hypersphere support vector machine model is established and the problem is solved by SMO. Finally, the SVM model and BP model are selected for prediction to verify the new model.
Results

Our research proves that the rms relative error of the CKM / SMO-SVM model is only 2.32%, which is 0.67% and 1.56% lower than the SVM and BP models, respectively, and the optimization speed is faster.
Conclusions

The model proposed in this paper utilizes Hyper-sphere SVM which is suitable for Gaussian kernel function to achieve faster and more accurate load forecasting, which can provide more accurate services for energy spot transactions and energy scheduling plans.
Transcriptome-wide isolation and expression profiles of NF-Y gene family in male cone development and hormone treatment of Chinese pine (Pinus tabuliformis)
Authors: Guo Yingtian , Niu Shihui , Li Wei 
Published: April 2020

Abstract
Background

Conifers and angiosperms have difference in reproductive development, especially for flowering. It is known that NUCLEAR FACTOR Y (NF-Y) transcription factor play an important role in flowering, drought stress and GA, ABA signaling, but, little known in auxin, salicylic acid, jasmonic acid, etc. Moreover, the NF-Y genes family has been mainly analyzed in angiosperms, but it has not been comprehensively reported in conifers.
Results

In this study, we identified 9 NF-YA, 9 NF-YB, and 10 NF-YC genes in Pinus tabuliformis using Arabidopsis NF-Y protein sequences as queries. Besides, by comparing conserved regions and phylogenetic relationships of the PtNF-Ys, we found that the NF-Ys were both conserved and altered during evolution. PtTFL2, PtCO, PtNF-YC1 and PtNF-YC4 were exploited by expression profile in male cone development and the correlation analysis. In addition, NF-YC1/4 can interact with DPL by yeast two-hybrid assays and BiFC. The multiple types of phytohormones-responsive cis-elements (ABA, JA, IAA, SA) were present and many NF-Y genes responded positively to SA and as opposed to IAA and JA.
Conclusions

Twenty-eight PtNF-Ys were identified and bioinformatic characterization of NF-Y genes including conserved regions, phylogenetic relationships, gene-motifs, was carried out. Two candidate genes (NF-YC1 and NF-YC4) were found to be involved in the regulation of conifer flowering and gibberellin signalling. The cis-elements and hormone transcriptome analysis revealed that the potential role of NF-Ys in conifers resistance. This study provides the basis for improved understanding of NF-Y genes function in conifers.
Evaluation of the Scale-up and Implementation of Mind, Exercise, Nutrition…Do It! (MEND) in British Columbia: A Hybrid Trial Type 3 Evaluation
Authors: Liu Sam , Weismiller Joy , Strange Karen , Forster-Coull Lisa , Bradbury Jennifer , Warshawski Tom , Naylor Patti-Jean 
Published: April 2020

Abstract
Background The Mind, Exercise, Nutrition…Do it! (MEND) childhood obesity intervention was implemented in British Columbia (B.C.), Canada from April 2013 to June 2017. The study objective was: a) to describe and explore program reach, attendance, satisfaction, acceptability, fidelity, and facilitators and challenges to implementation during scale-up and implementation of MEND in B.C. while b) monitoring program effectiveness in improving children’s body mass index (BMI) z-score, waist circumference, dietary and physical activity behaviours, and psychological well-being.Methods This prospective, pragmatic implementation evaluation (Hybrid Type 3 design) recruited families with children aged 7-13 with a BMI ≥ 85th percentile for age and sex. The 10-week MEND B.C. program was delivered in 27 sites, throughout all five B.C. health regions (Northern, Interior, Island, Fraser, and Vancouver Coastal) over four years. A mixed-method approach was used to collect and analyze the data. Evaluation measures included: program reach, attendance, fidelity, acceptability, satisfaction, facilitators and challenges to implementation, and effectiveness (change in children’s BMI z-score, physical activity, screen-time, eating behaviours, self-esteem and emotional distress).Results 136 MEND B.C. programs were delivered over four years. The program reached 987 eligible children. 755 (76.5%) children completed the program. The average program attendance was 81.5%. Parents reported the program content was easy to understand, culturally suitable for their family, respectful of their family's financial situation and provided adequate information to build a healthy lifestyle. Children achieved significant positive changes across all four evaluation years in BMI z-score, nutrition behaviours, physical activity levels, hours of screen time per week and emotional distress (p<0.05). Challenges to continued program implementation included: recruitment, resource requirement for implementation and the need to tailor the program locally to be more flexible and culturally relevant.Conclusions Scaling up efficacious childhood obesity interventions into real-world settings is critical to combat the obesity epidemic. Future family-based childhood obesity management interventions need to explore strategies to enhance program delivery flexibility while optimizing the use of health care resources.
The Role of Pruriceptors in Enhanced Sensitivities to Pruritogens in a Murine Model of Chronic Compression of Dorsal Root Ganglion
Authors: Wang Tao , Tao Jin , Fang Yehong , Ma Chao 
Published: April 2020

Abstract
Background: Chronic pruritus is a symptom that commonly observed in neurological diseases. It has been hypothesized that the chronic pruritus may result from sensitization of itch-signaling pathways but the mechanisms remain obscure.Methods: In this study, we established a mouse model of chronic compression of dorsal root ganglion (CCD) and injected various pruritogenic and algogenic agents intradermally to the calf skin ipsilateral to the compressed DRG. We additionally investigated if pruritogen-evoked activities of dorsal root ganglion (DRG) neurons is enhanced in this model. The expression of TRPV1, CGRP and H1R was detected with immunoflorescent staining. DRG neurons response to four agents using in vivo calcium imaging.Results: Compared to the naïve mice, a significant increase in itch-related behaviors was observed in the CCD mice after the injection of pruritogens including histamine and BAM8-22, but not after the injection of algogenic agents including capsaicine and 5-HT, although all the above agents evoked enhanced pain-related behaviors toward the injected site. In vivo calcium imaging revealed that compressed DRG neurons exhibited significantly enhanced responses to histamine and BAM8-22. Immunoflorescent staining also showed that the histamine receptor H1 and the capsaicin receptor TRPV1 were significantly upregulated in DRG neurons.Conclusions: Our findings indicated that sensitization of primary pruriceptive neurons may underlie the enhanced itch sensation after chronic compression of DRG neurons in mice, and may play a role in chronic pruritus in neurological diseases.
Diet Quality and Mental Health Amongst Acute Inpatient Psychiatric Patients
Authors: Gill Raveena , Tyndall Sean F , Vora Darshini , Hasan Rashedul , Megna James , Leontieva Luba 
Published: April 2020

Abstract
BackgroundPoor diet quality has been found to be prevalent in people with mental illness [71] and even contribute to mental illness [71]. The purpose of this exploratory study is to examine the relationship between diet quality, mental health problems, socioeconomic variables, physical activity level, and body mass index amongst acute psychiatric inpatients.MethodThe study sample were 100 adult inpatients. Tools administered were Eating Habit Questionnaires (Dana Farber Institute) and the KIDMed index to assess food compliance in accordance with a Mediterranean diet. The Index marks all individuals as either having an “unhealthy score” or “healthy score”. The study utilized a descriptive correlation research design.ResultsThe results showed that 75% of the patients displayed an unhealthy score as per the KIDMed index. The findings displayed an inverse relationship of BMI and the KIDMed score. There was a significant positive correlation between the level of education and the KIDMed score. There is a positive correlation towards increased consumption of sugar in schizophrenic patients. There was no statistical significance between age, gender, income and physical activity with regards to the KIDMed score.Conclusionpsychiatric inpatients display unhealthy eating habits which is likely both an effect of and a contributing factor to the various mental illnesses. Prospective interventional randomized controlled studies are necessary for clarification of cause-effect relationships.