bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of cardiac magnetic resonance on the diagnosis of hypertrophic cardiomyopathy - a 10-year experience with over 1000 patients
Authors: Śpiewak Mateusz , Kłopotowski Mariusz , Ojrzyńska Natalia , Petryka-Mazurkiewicz Joanna , Miłosz-Wieczorek Barbara , Mazurkiewicz Łukasz , Grzybowski Jacek , Bilińska Zofia , Witkowski Adam , Marczak Magdalena 
Published: September 2020

Abstract
Objectives
To assess the value of cardiac MRI in comparison to echocardiography in consecutive patients with previously diagnosed and new suspected hypertrophic cardiomyopathy (HCM).

Methods
All MRI studies of patients with HCM or suspected disease performed at our centre within a 10-year time period were evaluated. Initial diagnoses (echocardiography-based) and final (MRI-based) diagnoses were compared in subgroups, and the discrepancies were recorded.

Results
A total of 1006 subjects with HCM or suspected HCM were identified (61% males, 39% females; median age, 49.1 years; interquartile range, 34.9–60.4). In 12 (2.2%) out of 550 patients with known HCM, MRI indicated a diagnosis other than HCM, including but not limited to the subaortic membrane (n = 1, 8.3%) or mild left ventricular hypertrophy (n = 5, 41.7%). Among all patients with suspected HCM (n = 456), MRI diagnosis was different from HCM in 5.3% (n = 24) of patients. In an additional 20.4% of patients (n = 93), no significant hypertrophy was present. In total, among patients with suspected HCM, MRI led to clear HCM diagnosis in 204 (44.7%) patients. Among patients with a history of uncontrolled hypertension suspected of having HCM, MRI aided in identifying cardiomyopathy in 47.9% of patients. This subgroup contained the largest proportion of patients with an ambiguous diagnosis, namely, 29.6% compared with 13.8% in the remaining groups of patients with suspected HCM (p = 0.0001).

Conclusions
In a small but important group of patients with ultrasound-based HCM, cardiac MRI can diagnose previously unknown conditions and/or refute suspected cardiomyopathy. The diagnostic yield of MRI when compared to echocardiography in patients suspected of having HCM is 44.7%.

Key Points
• Out of 550 patients previously diagnosed with echocardiography but without magnetic resonance imaging (MRI) as having hypertrophic cardiomyopathy (HCM), we diagnosed a different disease in 12 (2.2%) patients using MRI.
• Among patients with suspected HCM based on echocardiography, MRI led to clear HCM diagnosis in 44.7% of patients.
• In patients with a history of uncontrolled hypertension suspected, based on an echocardiogram, of having HCM, MRI aided in identifying cardiomyopathy in 47.9% of patients. This subgroup contained the largest proportion of patients with an ambiguous diagnosis.
Experimental visualization of aerodynamic sound sources using parallel phase-shifting interferometry
Authors: Tanigawa Risako , Yatabe Kohei , Oikawa Yasuhiro 
Published: September 2020

Abstract
Aerodynamic sound is one of the causes of noise in high-speed trains, automobiles, and wind turbines. To investigate the characteristics of aerodynamic sound generation, measurements around the sound sources are required. Aerodynamic sound is typically measured using microphones. However, microphones cannot capture the near-field of aerodynamic sound because they become new noise sources inside the air flow. To observe the aerodynamic sound near-field, we performed two-dimensional visualization of aerodynamic sound using an optical method. The optical method used in this research, parallel phase-shifting interferometry (PPSI), can detect the pressure within the measurement area as variations of the phase of light. PPSI can therefore visualize the pressure fields. We visualized both the sound pressure and flow components of the sound generated by flow around a square cylinder and flat plates. The visualized pressure fields are provided as animations in the online resources. Analysis of the sound and flow component time variations confirmed the correlations between them.

Graphic abstract
Differential clinical impact of chronic total occlusion revascularization based on left ventricular systolic function
Authors: Kook Hyungdon , Yang Jeong Hoon , Cho Jae Young , Jang Duck Hyun , Kim Min Sun , Lee Juneyoung , Lee Seung Hun , Joo Hyung Joon , Park Jae Hyoung , Hong Soon Jun , Kim Je Sang , Lee Hyun Jong , Choi Rak Kyeong , Choi Young Jin , Park Jin Sik , Song Young Bin , Choi Jin-Ho , Hahn Joo-Yong , Gwon Hyeon-Cheol , Lim Do-Sun , Choi Seung-Hyuk , Yu Cheol Woong 
Published: September 2020

Abstract
Background
The effect of chronic total occlusion (CTO) revascularization on survival remains controversial. Furthermore, data regarding outcome differences for CTO revascularization based on left ventricular systolic function (LVSF) are limited.
The differential outcomes from CTO revascularization in patients with preserved LVSF (PLVSF) versus reduced LVSF (RLVSF) were assessed.

Methods
A total of 2,173 CTO patients were divided into either a PLVSF (n = 1661, Ejection fraction ≥ 50%) or RLVSF (n = 512, < 50%) group. Clinical outcomes were compared between successful CTO revascularization (SCR) versus optimal medical therapy (OMT) within each group. The primary endpoint was a composite of all-cause death or non-fatal myocardial infarction. Inverse probability of treatment weighting for endpoint analysis and a contrast test for comparison of survival probability differences according to LVSF were used.

Results
Patients with RLVSF had a mean 37% ejection fraction (EF) and 19% had EF < 30%. The median follow-up duration was 1,138 days. Regardless of LVSF, the primary endpoint incidence was significantly lower in patients treated with SCR [RLVSF: 29.7% vs. 49.7%, hazard ratio (HR) = 0.46, 95% confidence interval (CI): 0.36–0.62, p < 0.0001; PLVSF 7.3% vs. 16.9%, HR = 0.68, 95% CI: 0.54–0.93, p = 0.0019], which was mainly driven by a reduction in cardiac death. The difference in survival probability was greater and became more pronounced over time in patients with RLVSF than with PLVSF (1-year, p = 0.197; 3-years, p = 0.048; 5-years, p = 0.036).

Conclusions
SCR was associated with better survival benefit than OMT regardless of LVSF. The benefit was greater and became more significant over time in patients with RLVSF versus PLVSF.

Graphic abstract
The plate body: 3D ultrastructure of a facultative organelle of alveolar epithelial type II cells involved in SP-A trafficking
Authors: Mühlfeld Christian , Wrede Christoph , Molnár Viktor , Rajces Alexandra , Brandenberger Christina 
Published: September 2020

AbstractPlate bodies are facultative organelles occasionally described in the adult lungs of various species, including sheep and goat. They consist of multiple layers of plate-like cisterns with an electron dense middle bar. The present study was performed to elucidate the three-dimensional (3D) characteristics of this organelle and its presumed function in surfactant protein A (SP-A) biology. Archived material of four adult goat lungs and PFA-fixed lung samples of two adult sheep lungs were used for the morphological and immunocytochemical parts of this study, respectively. 3D imaging was performed by electron tomography and focused ion beam scanning electron microscopy (FIB-SEM). Immuno gold labeling was used to analyze whether plate bodies are positive for SP-A. Transmission electron microscopy revealed the presence of plate bodies in three of four goat lungs and in both sheep lungs. Electron tomography and FIB-SEM characterized the plate bodies as layers of two up to over ten layers of membranous cisterns with the characteristic electron dense middle bar. The membranes of the plates were in connection with the rough endoplasmic reticulum and showed vesicular inclusions in the middle of the plates and a vesicular network at the sides of the organelle. Immuno gold labeling revealed the presence of SP-A in the vesicular network of plate bodies but not in the characteristic plates themselves. In conclusion, the present study clearly proves the connection of plate bodies with the rough endoplasmic reticulum and the presence of a vesicular network as part of the organelle involved in SP-A trafficking.
Impact of geostatistical reconstruction approaches on model calibration for flow in highly heterogeneous aquifers
Authors: Siena Martina , Riva Monica 
Published: September 2020

AbstractOur study is aimed at assessing the extent at which relying on differing geostatistical approaches may affect characterization of the connectivity of geomaterials (orfacies) and, in turn, model calibration outputs in highly heterogeneous aquifers. We set our study within a probabilistic framework, by relying on a numerical Monte Carlo (MC) approach. The reconstruction of the spatial distribution of geomaterials and flow simulations are patterned after a field scenario corresponding to the aquifer system serving the city of Bologna (Northern Italy). Two collections of MC realizations of facies distributions, conditional on available lithological data, are generated through two alternative geostatistically-based techniques, i.e., Sequential Indicator and Transition-Probability simulation. Hydraulic conductivity values of the least- and most-conductive facies are estimated within each MC simulation in the context of a Maximum Likelihood (ML) approach by considering available piezometric data. We provide evidence that the choice of the facies reconstruction technique (1) impacts the degree of connectivity of facies whose proportions are close to the percolation threshold while (2) is not sensibly affecting the connectivity associated with facies whose proportions are much larger than the percolation threshold. By relying on the unique (lithological and hydrological) data-set at our disposal, we also explore the performance of ML-based model identification criteria to (1) discriminate amongst competitive facies reconstruction geostatistical models and (2) quantify the (posterior probabilistic) weight associated with each model. We then show that ML-based model averaging provides estimates of hydraulic heads which are slightly more in agreement with available data when compared to the best-performing realization in the T-PROGS set than considering its counterpart associated with the SISIM-based collection.
Mortality and thermal environment (UTCI) in Poland—long-term, multi-city study
Authors: Kuchcik Magdalena 
Published: September 2020

AbstractThe aim of the study was to establish to what extent extreme thermal conditions have changed and how they affected mortality, and what conditions favor lower mortality rates or conversely, higher mortality rates. Heat/cold exposure was measured with the Universal Thermal Climate Index (UTCI). Daily mortality and meteorological data for 8 large Polish cities (Białystok, Gdańsk, Kraków, Lublin, Łódź, Poznań, Warszawa, and Wrocław) in the period 1975–2014 were analyzed. Generalized additive models were used to investigate the relationship between UTCI and mortality, and TBATS models were used for the evaluation of time series UTCI data. Most of the cities experienced a clear and statistically significant at p ≤ 0.05 decrease in cold stress days of 0.8–3.3 days/year and an increase in the frequency of thermal heat stress days of 0.3–0.6 days/year until 1992–1994. There was a clear difference as regards the dependence of mortality on UTCI between cities located in the “cooler” eastern part of Poland and the “warmer” central and western parts. “Cool” cities were characterized by a clear thermal optimum, approx. in the range of 5–30 °C UTCI, changing slightly depending on cause of death, age, or sex. For UTCI over 32 °C, in most of the cities except Gdańsk and Lublin, the relative risk of death (RR) rose by 10 to 20%; for UTCI over 38 °C, RR rose to 25–30% in central Poland. An increase in mortality on cold stress days was noted mainly in the “cool” cities: RR of total mortality increased even by 9–19% under extreme cold stress.
Long-term feasibility of the new sutureless excimer laser-assisted non-occlusive anastomosis clip in a pig model
Authors: de Boer B. , van Doormaal T. P. C. , Tulleken C. A. F. , Regli L. , van der Zwan A. 
Published: September 2020

Abstract
Background
High flow bypass surgery can be a last resort procedure for patients suffering from complex neurovascular pathology. Temporary occlusion of a recipient artery in these patients could result in debilitating neurological deficits. We developed a sutureless, mechanical anastomotic connection device, the SELANA clip (Sutureless Excimer Laser-Assisted Non-occlusive Anastomosis clip: SEcl). In the present study, we aim to determine the long-term non-inferiority of the SEcl technique compared with historical data of the conventional ELANA anastomosis technique.

Methods
A total of 18 SEcl bypasses were created on the carotid artery in a porcine model in 6 different survival groups. Mean application times, flap retrieval rates, hemostasis, patency, flow, endothelialization, and remodeling were assessed.

Results
The mean application time of the SEcl anastomoses was 15.2 ± 9.6 min, which was faster compared with the conventional ELANA anastomoses. The flap retrieval rate of the SEcl anastomoses was 86% (32/37). Direct hemostasis was achieved in 89% (33/37) SEcl anastomoses. Patency in all surviving animals was 94% (17/18). Bypass flow after six months was 156.5 ± 24.7 mL/min. Full endothelialization of the SEcl pins was observed after 3 weeks.

Conclusion
The SEcl technique is not inferior to the ELANA technique regarding patency, flap retrieval rate, flow, and endothelialization. On the basis of a significantly shorter application time and superior hemostasis, the SEcl technique could be preferable over the ELANA technique. A pilot study in patients is a logical next step based on our current results.
African League Against Rheumatism (AFLAR) preliminary recommendations on the management of rheumatic diseases during the COVID-19 pandemic
Authors: Akintayo Richard Oluyinka , Bahiri Rachid , El Miedany Yasser , Olaosebikan Hakeem , Kalla Asgar Ali , Adebajo Adewale Olukayode , Migowa Angela Nyangore , Slimani Samy , Koussougbo Ouma Devi , Kawther Ben Abdelghani , Akpabio Akpabio Akanimo , Ghozlani Imad , Dey Dzifa , Hassan Waleed A. , Govind Nimmisha , Makan Kavita , Mohamed Abdelgaffar , Genga Eugene Kalman , Ghassem Mohamed Khattry Ahmed , Mortada Mohamed , Hamdi Wafa , Wabi Moudjib O. , Tikly Mohammed , Ngandeu-Singwe Madeleine , Scott Christian 
Published: September 2020

AbstractObjectivesTo develop recommendations for the management of rheumatic and musculoskeletal diseases (RMDs) during the COVID-19 pandemic.MethodA task force comprising of 25 rheumatologists from the 5 regions of the continent was formed and operated through a hub-and-spoke model with a central working committee (CWC) and 4 subgroups. The subgroups championed separate scopes of the clinical questions and formulated preliminary statements of recommendations which were processed centrally in the CWC. The CWC and each subgroup met by several virtual meetings, and two rounds of voting were conducted on the drafted statements of recommendations. Votes were online-delivered and recommendations were pruned down according to predefined criteria. Each statement was rated between 1 and 9 with 1–3, 4–6 and 7–9 representing disagreement, uncertainty and agreement, respectively. The levels of agreement on the statements were stratified as low, moderate or high according to the spread of votes. A statement was retired if it had a mean vote below 7 or a ‘low’ level of agreement.ResultsA total of 126 initial statements of recommendations were drafted, and these were reduced to 22 after the two rounds of voting.ConclusionsThe preliminary statements of recommendations will serve to guide the clinical practice of rheumatology across Africa amidst the changing practices and uncertainties in the current era of COVID-19. It is recognized that further updates to the recommendations will be needed as more evidence emerges.Key Points• AFLAR has developed preliminary recommendations for the management of RMDs in the face of the COVID-19 pandemic.• COVID-19 is an unprecedented experience which has brought new concerns regarding the use of some disease-modifying anti-rheumatic drugs (DMARDs), and these recommendations seek to provide guidelines to the African rheumatologists.• Hydroxychloroquine shortage has become rampart across Africa as the drug is being used as prophylaxis against COVID-19 and this may necessitate a review of treatment plan for some patients with RMDs.• Breastfeeding should continue for as long as possible if a woman is positive for SARS-CoV-2 as there is currently no evidence that the infection can be transmitted through breast milk.
Four different assessment practices: how university teachers handle the field of tension between professional responsibility and professional accountability
Authors: Jedemark Marie , Londos Mikael 
Published: September 2020

AbstractVarious efforts have been made in higher education in Sweden to meet the demand for more transparent governance and increased efficiency and quality. The purpose of this article is to investigate how university teachers handle standardized models for assessment and examination and orientate in this field of tension between professional responsibility and professional accountability. This study examines school-based courses in teacher education programs at a university and is based on observations from 20 seminars, 10 interviews with university teachers, and 11 focus group interviews with 55 students. The results show that university teachers interpret governing documents in different ways leading to a lack of equivalence. Within one course, four assessment practices are identified: governance as confirmation, governance with need for reinforcement, governance as distrust, and governance as others’ responsibility. This study reveals the variation in university teachers’ professional assessment practices that challenge and interplay with the context of a curriculum in different ways. Aspects of the university teachers’ professional obligation are under tension in the context of a more pronounced accountability. University teachers’ professional assessment practices emerges as fragmented in terms of what professional responsibility includes and what professional discretion involves.
Smoking inequality across genders and socio-economic positions. Evidence from Italian data
Authors: Di Novi Cinzia , Jacobs Rowena , Migheli Matteo 
Published: September 2020

AbstractThere has been a dearth of literature on smoking inequalities, in spite of its contribution to health inequalities. We exploit Italian individual-level data from repeated cross-sections of the annual household survey, “Aspects of Daily Life,” that was part of the Multipurpose Survey carried out by the Italian National Statistical Office (ISTAT) for the period 1999–2012 to identify the main socio-demographic characteristics that determine smoking inequalities. We use the Concentration Index to identify in which groups smoking is relatively more prevalent. We find that, among men, pro-rich inequality is driven by members of the lower socio-economic positions, while we observe the opposite for women. We encourage policymakers to address the issue of smoking inequalities, which the current policies have largely disregarded.
Hierarchical porous poly(l-lactic acid)/SiO2 nanoparticles fibrous membranes for oil/water separation
Authors: Lu Zihan , Zia Qasim , Meng Jinmin , Liu Ting , Song Jun , Li Jiashen 
Published: September 2020

AbstractA two-step strategy has been developed to introduce silica nanoparticles into highly porous poly(l-lactic acid) (PLLA) nanofibers. Silica nanoparticles (SiNPs) were firstly synthesized and then modified to be hydrophobic. After PLLA/SiNPs composite fibrous membranes were electrospun and collected, they were re-crystallized by acetone at room temperature for a few minutes. With the re-arrangement of PLLA chains, the nano-/micro-electrospun fibres were transformed from non-porous ones to be porous ones with high surface area. Consequently, SiNPs that were completely covered by PLLA before acetone treatment showed up at the fibre surface. Higher PLLA crystallization also enhanced the Young’s modulus and tensile strength (420 and 8.47 MPa) of the composite membrane. However, incorporation of SiNPs into porous PLLA membranes reduced their modulus and tensile strength (280.66 and 5.92 MPa), but an increase in strain to fracture (80.82%) was observed. Scanning electron microscopy (SEM), focused ion beam SEM, transmission electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction were applied to confirm the presence of SiNP in PLLA fibres. The presence of SiNPs inside and outside fibres enhances the hydrophobicity of PLLA/SiNPs nano-fibrous membrane as the water contact angle is greater than 150°. The oil absorption of these porous composite membranes was also tested using four different oils, which can reach the highest absorption capacity when the weight ratio of PLLA and SiNPs is 1:1. The flux of prepared membranes was investigated, and results indicated that SiNPs-loaded membrane effectively enhanced the flux (5200 Lm−2 h−1).
Relationships Between Religiosity and Naturally Occurring Social Interaction
Authors: Nezlek John B. 
Published: September 2020

AbstractFor 2 weeks, participants (282 US collegians) used a diary technique to describe the social interactions they had each day. These descriptions included how enjoyable the interaction was, how confident they felt, and how intimate the interaction was. They also completed a measure of Allport’s Intrinsic–Extrinsic religious orientation, the Christian Orthodoxy scale, and the Beck Depression Inventory. A series of multilevel modeling analyses found that enjoyment and confidence in social interaction were positively related to the Extrinsic Personal factor of the IE scale, whereas intimacy of interactions was not related to any of these measures. These relationships remained after controlling for orthodox beliefs and depression. These results suggest that the extent to which people find comfort in religious beliefs and practices (e.g., prayer) is positively related to the quality of their daily social experiences.
Longitudinal Linkages Between Father and Mother Autonomy Support and Adolescent Problem Behaviors: Between-Family Differences and Within-Family Effects
Authors: Vrolijk Paula , Van Lissa Caspar J. , Branje Susan J. T. , Meeus Wim H. J. , Keizer Renske 
Published: September 2020

AbstractDespite existing evidence on negative associations between parental autonomy support and children’s internalizing and externalizing problem behavior, it is difficult to draw conclusions on the effect that parents’ autonomy support has on children’s problem behavior. This study contributed to the existing literature by unraveling the temporal ordering of parental autonomy support and adolescent problem behavior. In addition, this study examined whether these linkages differed by parent’s sex, child sex, and reporter of autonomy support. Data of 497 adolescents (mean age at T1 = 13.03 years, percentage male = 56.9) and their parents from six annual waves of the Dutch study Research on Adolescent Development And Relationships (RADAR) were used. The results showed that stable differences between families explained most linkages between autonomy support and problem behavior. Adolescents with fewer problem behaviors have fathers (both child- and parent-reported) and mothers (only child-reported) who are more autonomy supportive. The results did not differ between boys and girls. The findings suggest that prior studies may have overstated the existence of a causal effect of parental autonomy support on adolescent problem behavior.