bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Federal Reserve’s Dollar Swap Lines and the European Central Bank during the global financial crisis of 2007–09
Authors: Carré Emmanuel , Le Maux Laurent 
Published: April 2020

AbstractAlthough the literature has studied the role of the Federal Reserve as the global lender of last resort in 2007–09, many aspects of the Dollar Swap Lines to the European Central Bank need further exploration. Accordingly, we provide original evidence about the auction operations, allotted amounts and interest rates with regard to the Federal Reserve’s dollar swaps and the European Central Bank’s dollar provision. More specifically, we examine the demand side of the Dollar Swap Lines (whereas the existing literature mentions the supply side only) and we scrutinise the interest rate (whereas the literature concentrates on volumes) set by the Federal Reserve, and also the rate set by the European Central Bank. Our findings cast light on the nature of the relationship between the Federal Reserve and the European Central Bank. Finally, we contribute to the literature on the global lender of last resort by coining the notion of the financial dilemma, under the dollar system within a framework of globalised financial markets.
Early Postoperative Endoscopic Recurrence in Crohn’s Disease Is Characterised by Distinct Microbiota Recolonisation
Authors: Machiels Kathleen , Pozuelo del Río Marta , Martinez-De la Torre Adrian , Xie Zixuan , Pascal Andreu Victòria , Sabino João , Santiago Alba , Campos David , Wolthuis Albert , D’Hoore André , De Hertogh Gert , Ferrante Marc , Manichanh Chaysavanh , Vermeire Séverine 
Published: April 2020

AbstractBackground and AimsIntestinal microbiota dysbiosis is implicated in Crohn’s disease [CD] and may play an important role in triggering postoperative disease recurrence [POR]. We prospectively studied faecal and mucosal microbial recolonisation following ileocaecal resection to identify the predictive value of recurrence-related microbiota.MethodsMucosal and/or faecal samples from 121 CD patients undergoing ileocaecal resection were collected at predefined time points before and after surgery. Ileal biopsies were collected from 39 healthy controls. POR was defined by a Rutgeerts score ≥i2b. The microbiota was evaluated by 16S rRNA sequencing. Prediction analysis was performed using C5.0 and Random Forest algorithms.ResultsThe mucosa-associated microbiota in CD patients was characterised by a depletion of butyrate-producing species (false discovery rate [FDR] &lt;0.01) and enrichment of Proteobacteria [FDR = 0.009] and Akkermansia spp. [FDR = 0.02]. Following resection, a mucosal enrichment of Lachnospiraceae [FDR &lt;0.001] was seen in all patients but in POR patients, also Fusobacteriaceae [FDR &lt;0.001] increased compared with baseline. Patients without POR showed a decrease of Streptococcaceae [FDR = 0.003] and Actinomycineae [FDR = 0.06]. The mucosa-associated microbiota profile had good discriminative power to predict POR, and was superior to clinical risk factors. At Month 6, patients experiencing POR had a higher abundance of taxa belonging to Negativicutes [FDR = 0.04] and Fusobacteria [FDR = 0.04] compared with patients without POR.ConclusionsMicrobiota recolonisation after ileocaecal resection is different between recurrence and non-recurrence patients, with Fusobacteria as the most prominent player driving early POR. These bacteria involved in the early recolonisation and POR represent a promising therapeutic strategy in the prevention of disease recurrence.
Alphabetical Author Order, Intellectual Collaboration and High-Skilled Migration
Authors: Li Wenchao , Yi Junjian 
Published: April 2020

Abstract
We study the consequences of alphabetical author order in economics for job placements of economists, based on a context that enables a clean identification. Results using two different data sets both show that, relative to Chinese physicists and statisticians, Chinese economists with surname initials located later in the alphabet tend not to stay in the US and are more likely to work in China. Such effects of surname initials on job placements are clearly identified and represent a result of alphabetical author order, because in Chinese culture, names are seldom listed alphabetically in contexts other than joint publications in international economics journals.
Hot stuff. Anatomy of the sex market at the dawn of the twentieth century
Authors: Mortas Pauline 
Published: April 2020

Abstract
Drawing on a rich legal dossier on a violation of obscenity laws (the Trafford affair), this article studies the formation of a sex market in early twentieth-century Paris. Books and erotic photographs, contraceptives, sex toys and remedies for increasing sexual potency: the diversity of these products relating to sexual practices is clearly revealed by the case. The dossier demonstrates how this commercial enterprise drew on the benefits of industrialization, mass media and globalization for building its client-base and developing a transnational dimension. It also allows us to understand the strategies deployed to keep the sale of these objects clandestine, in a context where they were increasingly overseen by the authorities, revealing innovative forms of commercial exchange, based on an epistolary transvestism.
Peacekeeping Deployments and Mutinies in African Sending States
Authors: Schiel Rebecca , Powell Jonathan , Daxecker Ursula 
Published: April 2020

AbstractResearch on host-country effects of peacekeeping deployments has highlighted destabilizing consequences for contributing states, suggesting that deployments can increase the willingness and ability of soldiers to mutiny or attempt coups. Yet others expect that peacekeeping contributions may bring a variety of benefits, including improved civilian control of the armed forces. We reconcile these conflicting assessments in two ways. First, we identify important differences across peacekeeping organizations. Missions undertaken by the United Nations (UN) are generally better funded and equipped, invoke selection criteria that should produce fewer grievances than missions operated by regional organizations, and may be more risk averse. The benefits or hazards of peacekeeping can thus vary substantially, leading to different consequences for organizations. Second, the pros and cons of peacekeeping can incentivize mutinies and coups differently. When grievances are present, financial incentives of peacekeeping may prompt soldiers to prefer mutiny over coups to avoid being disqualified from future participation. We assess these expectations for African states’ participation in UN and non-UN peacekeeping operations from 1990 to 2011. We find no evidence that UN peacekeeping deployments increase mutiny risk, while non-UN deployments have a positive effect on the occurrence of mutiny. These findings remain robust across a large number of model specifications.
Twist1 induces chromosomal instability (CIN) in colorectal cancer cells
Authors: Khot Maithilee , Sreekumar Dyuthi , Jahagirdar Sanika , Kulkarni Apoorva , Hari Kishore , Faseela Elangoli Ebrahimkutty , Sabarinathan Radhakrishnan , Jolly Mohit Kumar , Sengupta Kundan 
Published: April 2020

Abstract
Twist1 is a basic helix-loop-helix transcription factor, essential during early development in mammals. While Twist1 induces epithelial-to-mesenchymal transition (EMT), here we show that Twist1 overexpression enhances nuclear and mitotic aberrations. This is accompanied by an increase in whole chromosomal copy number gains and losses, underscoring the role of Twist1 in inducing chromosomal instability (CIN) in colorectal cancer cells. Array comparative genomic hybridization (array CGH) analysis further shows sub-chromosomal deletions, consistent with an increased frequency of DNA double strand breaks (DSBs). Remarkably, Twist1 overexpression downmodulates key cell cycle checkpoint factors—Bub1, BubR1, Mad1 and Mad2—that regulate CIN. Mathematical simulations using the RACIPE tool show a negative correlation of Twist1 with E-cadherin and BubR1. Data analyses of gene expression profiles of patient samples from The Cancer Genome Atlas (TCGA) reveal a positive correlation between Twist1 and mesenchymal genes across cancers, whereas the correlation of TWIST1 with CIN and DSB genes is cancer subtype-specific. Taken together, these studies highlight the mechanistic involvement of Twist1 in the deregulation of factors that maintain genome stability during EMT in colorectal cancer cells. Twist1 overexpression enhances genome instability in the context of EMT that further contributes to cellular heterogeneity. In addition, these studies imply that Twist1 downmodulates nuclear lamins that further alter spatiotemporal organization of the cancer genome and epigenome. Notwithstanding their genetic background, colorectal cancer cells nevertheless maintain their overall ploidy, while the downstream effects of Twist1 enhance CIN and DNA damage enriching for sub-populations of aggressive cancer cells.
The effect of social participation on income-related inequality in health outcome among Chinese older adults
Authors: Sun Jian , Lyu Xiaoyin , Lyu Shoujun , Zhao Rui 
Published: April 2020

Abstract

Background
This study aimed to investigate the effect of social participation on income-related inequality in health outcome among older adults in China.

Methods
The panel data used in this study were sourced from the 2011 and 2014 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Furthermore, this study employed a concentration index to assess the income-related inequality in health outcome. Moreover, this study used the decomposition method of concentration index to analyse the effect of social participation on income-related inequality in health outcome.

Results
The total concentration index of Instrumental Activity of Daily Living (IADL) status decreased from 0.0257 in 2011 to 0.0172 in 2014. Furthermore, the total concentration index of psychological health decreased from 0.0309 in 2011 to 0.0269 in 2014. The decomposition analysis indicates that social participation made a major contribution to the pro-rich inequality in IADL status. Moreover, the results also indicate that social participation made a minor contribution to the pro-rich inequality in psychological health.

Conclusions
This study demonstrated that overall there were pro-rich inequalities in IADL status and psychological health among older adults in China. Moreover, social participation made a major contribution to the pro-rich inequality in IADL status, while it made a minor contribution to the pro-rich inequality in psychological health.
Optimization of flucloxacillin dosing regimens in critically ill patients using population pharmacokinetic modelling of total and unbound concentrations
Authors: Jager Nynke G L , van Hest Reinier M , Xie Jiao , Wong Gloria , Ulldemolins Marta , Brüggemann Roger J M , Lipman Jeffrey , Roberts Jason A 
Published: April 2020

Abstract

Background
Initial appropriate anti-infective therapy is associated with improved outcomes in patients with severe infections. In critically ill patients, altered pharmacokinetic (PK) behaviour is common and known to influence the achievement of PK/pharmacodynamic targets.

Objectives
To describe population PK and optimized dosing regimens for flucloxacillin in critically ill patients.

Methods
First, we developed a population PK model, estimated between-patient variability (BPV) and identified covariates that could explain BPV through non-linear mixed-effects analysis, using total and unbound concentrations obtained from 35 adult critically ill patients treated with intermittent flucloxacillin. Second, we validated the model using external datasets from two different countries. Finally, frequently prescribed dosing regimens were evaluated using Monte Carlo simulations.

Results
A two-compartment model with non-linear protein binding was developed and validated. BPV of the maximum binding capacity decreased from 42.2% to 30.4% and BPV of unbound clearance decreased from 88.1% to 71.6% upon inclusion of serum albumin concentrations and estimated glomerular filtration rate (eGFR; by CKD-EPI equation), respectively. PTA (target of 100%fT&gt;MIC) was 91% for patients with eGFR of 33 mL/min and 1 g q6h, 87% for patients with eGFR of 96 mL/min and 2 g q4h and 71% for patients with eGFR of 153 mL/min and 2 g q4h.

Conclusions
For patients with high creatinine clearance who are infected with moderately susceptible pathogens, therapeutic drug monitoring is advised since there is a risk of underexposure to flucloxacillin. Due to the non-linear protein binding of flucloxacillin and the high prevalence of hypoalbuminaemia in critically ill patients, dose adjustments should be based on unbound concentrations.
Rationale of a loading dose initiation for hydroxychloroquine treatment in COVID-19 infection in the DisCoVeRy trial
Authors: Lê Minh Patrick , Peiffer-Smadja Nathan , Guedj Jeremie , Néant Nadège , Mentré France , Ader Florence , Yazdanpanah Yazdan , Peytavin Gilles 
Published: April 2020

Abstract
Around the world, several dose regimens of hydroxychloroquine have been used for COVID-19 infection treatment, with the objective of identifying a short-term course. Hydroxychloroquine was found to decrease the viral replication in a concentration-dependent manner in vitro and to be more active when added prior to the viral challenge. A loading dose is used to rapidly attain a target drug concentration, which is usually considered as approximately the steady-state concentration. With a loading dose, the minimum effective concentration is reached much more rapidly than when using only the maintenance dose from the start. Thus, we propose a hydroxychloroquine sulphate dose regimen of 400 mg twice daily at Day 1 then 400 mg once daily from Day 2 to Day 10. We aim to evaluate this in the C-20-15 DisCoVeRy trial.
Dr. Agent: Clinical predictive model via mimicked second opinions
Authors: Gao Junyi , Xiao Cao , Glass Lucas M , Sun Jimeng 
Published: April 2020

Abstract

Objective
Prediction of disease phenotypes and their outcomes is a difficult task. In practice, patients routinely seek second opinions from multiple clinical experts for complex disease diagnosis. Our objective is to mimic such a practice of seeking second opinions by training 2 agents with different focuses: the primary agent studies the most recent visit of the patient to learn the current health status, and then the second-opinion agent considers the entire patient history to obtain a more global view.

Materials and Methods
Our approach Dr. Agent augments recurrent neural networks with 2 policy gradient agents. Moreover, Dr. Agent is customized with various patient demographics information and learns a dynamic skip connection to focus on the relevant information over time. We trained Dr. Agent to perform 4 clinical prediction tasks on the publicly available MIMIC-III (Medical Information Mart for Intensive Care) database: (1) in-hospital mortality prediction, (2) acute care phenotype classification, (3) physiologic decompensation prediction, and (4) forecasting length of stay. We compared the performance of Dr. Agent against 4 baseline clinical predictive models.

Results
Dr. Agent outperforms baseline clinical prediction models across all 4 tasks in terms of all metrics. Compared with the best baseline model, Dr. Agent achieves up to 15% higher area under the precision-recall curve on different tasks.

Conclusions
Dr. Agent can comprehensively model the long-term dependencies of patients’ health status while considering patients’ demographics using 2 agents, and therefore achieves better prediction performance on different clinical prediction tasks.
Determination of Bromate Ions in Drinking Water by Derivatization with 2-Methyl-2-Butene, Dispersive Liquid-Liquid Extraction and Gas Chromatography-Electron Capture Detection
Authors: Nabi Mehdi , Ghoreishi Sayed Mehdi , Behpour Mohsen 
Published: April 2020

Abstract

Background
A simple, rapid, selective and sensitive sample preparation and derivatization method was performed for determination of bromate ions in water by means of dispersive liquid-liquid extraction (DLLE) by gas chromatography-electron capture detection (GC-ECD). This method is based on 2-methyl-2-butene derivatization by bromine produced from bromate ions in acidic medium and extraction by n-hexane.

Objective
Derivatizing agent: It is cheap and available and it has high efficiency in reaction with Br2. Simplicity: Preparation and extraction process don't need to any specific equipment and procedure is completely simple and fast. Limit of detection: DL is as low as 0.43 µg/L.

Methods
Various effective factors on the derivatization and extraction efficiency, such as amount of derivatizing agent, volume of extraction solvent, bromide concentration, volume and concentration of sulfuric acid, type and volume of extracting and dispersing solvent, ionic strength, storage time before extraction and ECD makeup-gas flow rate were investigated.

Results
Under the optimum conditions, the method had a linear calibration curve ranging from 1.0 to 200.0 µg/L for bromate ions with a determination coefficient (R2) of 0.994 and the detection limit was 0.43 µg/L. The recovery percent and relative standard deviation for the determination of 1.0, 5.0 and 50.0 µg/L bromate ion was between 90 and 110%, and 3.0 and 8.0% (n = 3), respectively.

Conclusions
Finally, the method was successfully applied for the preconcentration and determination of bromate ions in water samples, and satisfactory results were obtained.

Highlights
(1) Fast, easy, accurate and economical innovative analysis of bromate ions in water and wastewater. (2) Determination of inorganic ion by GC-ECD after derivatization (3) Low detection limit (4) Optimization of different method parameters to obtain accurate results based on requirements of international standards, specifically ISO/IEC 17025.
Defining Hate Speech
Authors: Fino Audrey 
Published: April 2020

Abstract
This article looks at the international criminal law on hate speech that falls short of direct and public incitement to commit genocide. Using the most egregious form of hate speech that has been prosecuted as an international crime — that of direct and public incitement to genocide — as a baseline, the author analyses the legal parameters of hate speech as persecution (a crime against humanity) and hate speech as instigation (a mode of liability). In so doing, the author critically reviews the International Residual Mechanism for the International Criminal Tribunals’ (IRMCT) appeal judgment in the Šešelj case (Šešelj Appeal Judgment) in the light of prior case law of the International Military Tribunal of Nuremberg (IMT) and the International Criminal Tribunals for Rwanda and the former Yugoslavia (ICTR and ICTY respectively). The author submits that a plain reading of the Šešelj Appeal Judgment supports the view that it is only the more extreme form of incitement to violence, incitement to commit crimes, followed by actual violent acts, that may constitute hate speech amounting to the crime of persecution: incitement to discrimination or incitement to hatred as such do not qualify. Whether ‘incitement to violence’ absent the commission of crimes could qualify as persecution (a crime against humanity) remains an unsettled point. With regard to hate speech as instigation, the Šešelj Appeal Judgment’s restatement and application of the law causes less controversy: the substantial causal connection required for instigation was found to be direct in the circumstances of that case — even though directness is not a legal requirement for instigation. The author concludes that both these interpretations of hate speech are consistent with the earlier ad hoc tribunals’ jurisprudence and, more generally, with international human rights law which, with some controversial exceptions, allows criminalization only of the most extreme forms of incitement to violence.
Modeling the Putative Ancient Distribution of Aedes togoi (Diptera: Culicidae)
Authors: Peach Daniel A H , Matthews Benjamin J 
Published: April 2020

AbstractThe coastal rock pool mosquito, Aedes (Tanakius) togoi (Theobald) (Diptera: Culicidae), is found in coastal east Asia in climates ranging from subtropical to subarctic. However, a disjunct population in the Pacific Northwest of North America has an ambiguous heritage. Two potential models explain the presence of Ae. togoi in North America: ancient Beringian dispersal or modern anthropogenic introduction. Genetic studies have thus far proved inconclusive. Here we described the putative ancient distribution of Ae. togoi habitat in east Asia and examined the climatic feasibility of a Beringian introduction into North America using modern distribution records and ecological niche modeling of bioclimatic data from the last interglacial period (~120,000 BP), the last glacial maximum (~21,000 BP), and the mid-Holocene (~6000 BP). Our results suggest that suitable climatic conditions existed for Ae. togoi to arrive in North America through natural dispersal as well as to persist there until present times. Furthermore, we find that ancient distributions of suitable Ae. togoi habitat in east Asia may explain the genetic relationships between Ae. togoi populations identified in other studies. These findings indicate the utility of ecological niche modeling as a complementary tool for studying insect phylogeography.
Performance of Trichopria drosophilae (Hymenoptera: Diapriidae), a Generalist Parasitoid of Drosophila suzukii (Diptera: Drosophilidae), at Low Temperature
Authors: Colombari Fernanda , Tonina Lorenzo , Battisti Andrea , Mori Nicola 
Published: April 2020

Abstract
Survival and parasitism activity of Trichopria drosophilae Perkins adults, a cosmopolitan parasitoid of Drosophila spp., were studied under laboratory conditions using five constant temperatures at the lower range known for this enemy, from 4 to 20°C in 4°C increments. Drosophila suzukii Matsumura, an invasive pest of small fruits, was used as a host. Commercially available adult parasitoids were provided with 1) food and D. suzukii pupae; 2) food and no D. suzukii pupae; 3) no food and no pupae. The results show that adult females of T. drosophilae lived longer than males, and both generally benefitted from food supply. The highest level of survival was observed between 8 and 12°C for fed insects, irrespective of whether they were offered host pupae or not. The absence of food led to the highest mortality, but the parasitoid demonstrated considerably resistance to prolonged starvation. Successful parasitism increased steadily with temperature and reached the highest value at 20°C. Conversely, D. suzukii emergence rate was high after exposure of pupae to parasitoids at 4°C, while pupal mortality increased strongly with temperature until 12°C. The findings indicate that T. drosophilae is well adapted to the relatively cold conditions experienced in early spring and in autumn or at high elevations, when the host pupae could be largely available. The long lifespan of the adults and the ability to parasitize the host at low temperature make T. drosophilae potentially useful for the biocontrol of D. suzukii.