bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virtual arthroplasty follow-up: five-year data from a district general hospital
Authors: Fisher R , Hamilton V , Reader S , Khatun F , Porteous M 
Published: November 2019

Introduction Follow-up after hip and knee arthroplasty is advocated to identify asymptomatic loosening and improve patient satisfaction. There are, however, financial and time implications associated with regular clinic appointments. Assessment through virtual means has been suggested as an alternative. Materials and methods At the West Suffolk Hospital, following arthroplasty surgery of the lower limb, patients are followed-up via a questionnaire at one and five years postoperatively, then subsequently at five-yearly intervals. Patients are recalled based on the outcome of these assessments. Using a locally compiled data base we identified all patients reviewed between 2011 and 2015 using this virtual assessment process and examined their outcomes. Results During the five years of follow-up, 5,380 patients were eligible for assessment. Compliance varied from 77% follow up for hips and 83% for knees. Ten patients were recalled following total hip replacement, eight for x-ray changes and one for a poor satisfaction score. Five went on to undergo revision surgery. Some 56 recalls to clinic following knee arthroplasty were seen; 42 due to a poor Oxford Knee Score, 6 with associated x-ray abnormalities and 6 isolated abnormal x-rays. Five subsequently underwent revision surgery; 30 (54%) were discharged after initial review and 18 (32%) were referred to different subspecialties. As a result of the virtual review process, 4,219 clinic appointments were avoided, with no documented admissions as a result of a missed complication from virtual review. Discussion A virtual arthroplasty clinic significantly reduces the number of patients attending regular follow-up clinics, without compromising safe practice.
ANÁLISE EXPLORATÓRIA DOS DADOS CLIMÁTICOS E SUA INFLUÊNCIA NO Aedes aegypti, NO MUNICÍPIO DE CHAPECÓ/SC: RESULTADOS PARCIAIS
Authors: Matiola Cleusa , Ribeiro Eduardo Augusto Werneck 
Published: November 2019

A dengue é uma doença viral que vem colocando em risco parte da população do mundo. O vírus é transmitido pelo Aedes aegypti, também transmissor do zika vírus e da febre chikungunya. O número de A. aegypti é significativo em Santa Catarina ao longo dos anos. As variações climáticas contribuem para o aumento do vetor, porém as condições socioeconômicas da população e a ação antrópica também influenciam. O objetivo deste estudo é uma análise exploratória das variáveis climáticas e possíveis correlações com o aumento de número de mosquitos em Chapecó/SC. Para isto, foi realizado modelagem estatística do número de A. aegypti, disponibilizados pela Diretoria de Vigilância Epidemiológica de Santa Catarina (DIVE), com distribuição da precipitação, médias de temperatura mínimas e máximas com recorte diário, entre 2010 e 2017, fornecidos por Modern Era Retrospective-Analysis For Research and Applications (MERRA2) da NASA. A pesquisa se mostrou promissora, os dados de MERRA2, trazem uma escala temporal que possibilitaram o estudo do clima com a proliferação do mosquito, tendo em vista que nem toda cidade conta com estação meteorológica. Este trabalho apresenta resultados parciais da pesquisa ainda em desenvolvimento, no programa de mestrado profissional Clima e Ambiente do Instituto Federal de Santa Catarina (IFSC).
Analysing the chemistry in beauty blogs for curriculum innovation
Authors: Belova Nadja , Velikina Irina 
Published: November 2019

Abstract
Cosmetics play an important role in our everyday lives. However, the variety of different products and brands appears confusing to consumers. Products vary from basic, indispensable, everyday items such as soaps, shower gels and shampoos, to decorative cosmetics and high-end skin creams with specific, “innovative” ingredients for every skin type imaginable. In recent years, beauty blogs have become a popular platform to seek information on cosmetic products. Such blogs often contain chemistry-based content, which is only rarely written or at least double-checked by someone with a scientific background. Often such blogs reach a readership of several million users per month. But which role do chemical aspects play in beauty blog texts? This paper describes a qualitative content analysis of 60 recent posts from six popular English-language beauty blogs. The texts were coded according to categories such as the number of chemistry-related terms, supporting information for such terms, positive and negative claims regarding chemical aspects, references to studies etc. Based on the distribution of the categories, three main types of blogs could be distinguished: The “scientific type”, the “semi-scientific type” and “the non-scientific type”. By color-coding the different categories, a difference between these types can be easily depicted. The paper will discuss first findings and ideas on how to make use of corresponding analyses of beauty blogs for the teaching of chemistry.
Mathematical Study of a Class of Epidemiological Models with Multiple Infectious Stages
Authors: Bowong S. , Temgoua A. , Malong Y. , Mbang J. 
Published: November 2019

Abstract
This paper deals with the mathematical analysis of a general class of epidemiological models with multiple infectious stages for the transmission dynamics of a communicable disease. We provide a theoretical study of the model. We derive the basic reproduction number

R

0

$\mathcal R_0$

that determines the extinction and the persistence of the infection. We show that the disease-free equilibrium is globally asymptotically stable whenever

R

0

≤
1

$\mathcal R_0 \leq 1$

, while when

R

0

>
1

$\mathcal R_0 \gt 1$

, the disease-free equilibrium is unstable and there exists a unique endemic equilibrium point which is globally asymptotically stable. A case study for tuberculosis (TB) is considered to numerically support the analytical results.
Microtubule and Actin Differentially Regulate Synaptic Vesicle Cycling to Maintain High-Frequency Neurotransmission
Authors: Piriya Ananda Babu Lashmi , Wang Han-Ying , Eguchi Kohgaku , Guillaud Laurent , Takahashi Tomoyuki 
Published: November 2019

Cytoskeletal filaments such as microtubules (MTs) and filamentous actin (F-actin) dynamically support cell structure and functions. In central presynaptic terminals, F-actin is expressed along the release edge and reportedly plays diverse functional roles, but whether axonal MTs extend deep into terminals and play any physiological role remains controversial. At the calyx of Held in rats of either sex, confocal and high-resolution microscopy revealed that MTs enter deep into presynaptic terminal swellings and partially colocalize with a subset of synaptic vesicles (SVs). Electrophysiological analysis demonstrated that depolymerization of MTs specifically prolonged the slow-recovery time component of EPSCs from short-term depression induced by a train of high-frequency stimulation, whereas depolymerization of F-actin specifically prolonged the fast-recovery component. In simultaneous presynaptic and postsynaptic action potential recordings, depolymerization of MTs or F-actin significantly impaired the fidelity of high-frequency neurotransmission. We conclude that MTs and F-actin differentially contribute to slow and fast SV replenishment, thereby maintaining high-frequency neurotransmission.SIGNIFICANCE STATEMENTThe presence and functional role of MTs in the presynaptic terminal are controversial. Here, we demonstrate that MTs are present near SVs in calyceal presynaptic terminals and that MT depolymerization specifically prolongs the slow-recovery component of EPSCs from short-term depression. In contrast, F-actin depolymerization specifically prolongs fast-recovery component. Depolymerization of MT or F-actin has no direct effect on SV exocytosis/endocytosis or basal transmission, but significantly impairs the fidelity of high-frequency transmission, suggesting that presynaptic cytoskeletal filaments play essential roles in SV replenishment for the maintenance of high-frequency neurotransmission.
Adrenocortical carcinoma and pulmonary embolism from tumoral extension
Authors: Shekhar Skand , Gubbi Sriram , Papadakis Georgios Z , Nilubol Naris , Hannah-Shmouni Fady 
Published: November 2019

Summary
Adrenococortical carcinoma (ACC) is a rare cancer, occurring at the rate of one case in two million person years. Cushing syndrome or a mixed picture of excess androgen and glucocorticoid production are the most common presentations of ACC. Other uncommon presentations include abdominal pain and adrenal incidentalomas. In the present report, a 71-year-old male presented with abdominal pain and was eventually diagnosed with ACC. He was found to have pulmonary thromboembolism following an investigation for hypoxemia, with the tumor thrombus extending upto the right atrium. This interesting case represents the unique presentation of a rare tumor, which if detected late or left untreated is associated with poor outcomes, highlighting the need for a low index of suspicion for ACC when similar presentations are encountered in clinical practice.

Learning points:

ACC is a rare but aggressive tumor.

ACC commonly presents with rapid onset of hypercortisolism, combined hyperandrogenism and hypercortisolism, or uncommonly with compressive symptoms.

Clinicians should have a low index of suspicion for ACC in patients presenting with rapid onset of symptoms related to hypercortisolism and/or hyperandrogenism.

Venous thromboembolism and extension of the tumor thrombus to the right side of the heart is a very rare but serious complication of ACC that clinicans should be wary of.

The increased risk of venous thromboembolism in ACC could be explained by direct tumor invasion, tumor thrombi or hypercoagulability secondary to hypercortisolism.

Early diagnosis and prompt treatment can improve the long-term survival of patients with ACC.
Educación y competitividad: una aplicación del enfoque de Michael Porter en El Salvador. Periodo 2014-2018
Authors: Sibrián Sánchez Kevin Alexis , Escobar Bonilla Valeria Cristina 
Published: November 2019

El Salvador presenta la necesidad de garantizar un sistema educativo de calidad y de carácter universal, reconociendo el derecho a la educación que tiene cada individuo. Sin embargo, esto no es así, ya que se han presentado dificultades para formar el recurso humano con niveles de educación superior y capacitación continua. Esto se refleja en el bajo nivel de escolaridad promedio y la poca o nula capacidad para responder a las innovaciones tecnológicas.De acuerdo con Michael Porter, la formación del recurso humano requiere fortalecer la educación, hasta el punto de generar innovación en la economía, mejorando la productividad y competitividad en el ámbito global. Es así como, desde la óptica de Porter, la baja productividad y competitividad en El Salvador encuentra una de sus causas en la escasa formación del recurso humano, que implica que la mano de obra sea no especializada o semiespecializada. Parte del bajo nivel de competitividad reside precisamente en la poca atención al factor educativo. Esto se refleja en el reducido porcentaje de gasto público que se destina a educación, que pasó del 3.9 % del PIB al 3.8 % entre 2014 y 2017, según datos del Ministerio de Educación (Mined) y del Banco Central de Reserva (BCR) (Mined, 2018, p. 148).
IMAGERY CREATED AND REFLECTED IN MULTILINGUAL POETIC TRANSLATIONS
Authors: Yashkina Victoria 
Published: November 2019

Successful poetic text translation, as well as its entire possibility, has been of current relevance since the appearance of translations as they are, but have not received final solving. Linguists are proving failures of full conceptual, semantic and language preservation of the original in its translation. Both professionals and amateurs never stop arguing on the dilemma of equivalence versus adequacy. Translators offer numerous variants of one and the same poetic masterpiece with the aim of achieving maximum original beauty and sense. As a result, it becomes obvious, that the more different language translation samples appear, the better the original message of a poem is restored. In given article we concentrated our attention on multilingual translations of the original poems poems, specifically comparing grammar, lexical, phonetic and strophe-building translation variants and discussing discrepancies between the original and its Romanic and Slavic translations. The main aim lies in an attempt to prove that multilingual translation practice serves as a source for translation variants to add to each other or open different aspects of the original, and, possibly, to achieve perfect revealing of a poetic masterpiece. It has been proved by the research, that noncoincidence of certain translation equivalents accompanied by full correspondence of others, results in definite semantic loss. This fact underlines urgency of multilingual translations as means of achieving as full poetic texts comprehension as it is possible in other languages.
Védőoltásokkal kapcsolatos kételyek és elkötelezettség a magyarországi egészségügyi alapellátásban dolgozók körében
Authors: Kun Eszter , Benedek Angéla , Mészner Zsófia 
Published: November 2019

Abstract: Introduction: The attitude to immunization and the issue of vaccine hesitancy in health care workers (HCWs) have been studied in a former survey performed by ECDC (European Centre for Disease Prevention and Control). Aim: Our aim was to study the immunization attitude of primary care paediatricians, general practitioners and primary care nurses in Hungary. Method: We studied vaccine hesitancy in HCWs by way of a questionnaire, developed on the basis of a recent similar survey by ECDC in four countries. The online survey has been performed between May and July 2017. Altogether 765 questionnaires have been returned: 189 primary care paediatricians, 375 general practitioners working in adult or mixed practices, and 201 primary care nurses. The sample has been weighted to the country-specific features – e.g., location of the practice, residence and age of the HCWs – within each of the three groups, so from this aspect it can be considered representative. Results: Our results did not differ substantially from the international ECDC data. Approximately 2/3 of the primary care doctors and about 50% of the primary care nurses were convinced of the benefit and value of vaccines. Data on vaccine hesitancy were consolingly low, though the data on recommended vaccines were somewhat higher compared to the age related/NIP (National Immunization Plan) vaccines. The well-known vaccine scares – e.g., autism–MMR, etc., known also from the literature – could hardly been detected, and it can be explained by the voluntary participation in the study. The least supported vaccine is BCG, while the highest hesitancy rates are related to MMR in Hungary. Conclusion: The need to improve immunization-related communication among primary HCWs could clearly been detected – both in gradual and in post-gradual training programs. Orv Hetil. 2019; 160(48): 1904–1914.
“El impacto de las TIC en la vida moderna”
Authors: Briceño Díaz Freddy 
Published: November 2019

Los cambios en general que se han presentado en las dos (2) últimas décadas en aspectos como: globalización, Internet, tecnologías de las comunicaciones, tratados de libre comercio, economía internacional, la política, entre otros aspectos; ha ocasionado que nuevas organizaciones hayan surgido producto de las necesidades del mismo entorno, otras han adaptado sus procesos de acuerdo con los cambios que le impone su ámbito, pero también ha ocurrido que organizaciones con muchos años de experiencia, tradición y subsistencia en los mercados nacionales e internacionales hayan desaparecido.
Prognostic and Predictive Value of Microsatellite Instability, Inflammatory Reaction and PD-L1 in Gastric Cancer Patients Treated with Either Adjuvant 5-FU/LV or Sequential FOLFIRI Followed by Cisplatin and Docetaxel: A Translational Analysis from the ITACA-S Trial
Authors: Di Bartolomeo Maria , Morano Federica , Raimondi Alessandra , Miceli Rosalba , Corallo Salvatore , Tamborini Elena , Perrone Federica , Antista Maria , Niger Monica , Pellegrinelli Alessandro , Randon Giovanni , Pagani Filippo , Martinetti Antonia , Fucà Giovanni , Pietrantonio Filippo ,   on behalf of ITACA-S study group
Published: November 2019

Abstract

Background
Patients with high microsatellite instability (MSI) gastric cancer (GC) show improved survival and no benefit or harm from adjuvant and/or perioperative chemotherapy. The role of immune microenvironment in GC is largely unknown.

Materials and Methods
In the present study, 256 tumor tissue blocks were centrally collected from patients enrolled in ITACA-S, a randomized adjuvant trial of 5-FU/LV versus sequential FOLFIRI and cisplatin-docetaxel. MSI status was assessed by multiplex PCR, inflammatory reaction by H&E morphological assessment, and programmed death-ligand 1 (PD-L1) expression by immunohistochemistry.

Results
Overall, 9% patients had MSI-high tumors, 23% had high inflammatory reaction, 11% had tumor PD-L1 ≥ 1%, and 11% had stromal PD-L1 ≥ 1%. A significant association with disease-free survival (DFS) and overall survival (OS) was found for MSI-high (hazard ratio [HR], 0.43; p = .02; HR, 0.40; p = .02) and high inflammatory reaction (HR, 0.55; p = .010; HR, 0.53; p = .008) but not for PD-L1. At multivariable analysis, only MSI showed an independent association with both DFS (p = .02) and OS (p = .01), whereas inflammatory reaction showed an independent association only with OS (p = .04). Patients with tumor PD-L1 ≥ 1% had a significantly longer DFS in sequential chemotherapy than in than 5-FU/LV arm (interaction p = .04) and a trend for OS (interaction p = .12).

Conclusion
Our data suggest that MSI status could be a useful prognostic biomarker in patients with radically resected stage II–III GC and should be used as stratification factor in future trials. Tumor PD-L1 ≥ 1% should be further investigated as a potential predictor of benefit from intensive chemotherapy.
Development of certified reference materials for physicochemical analysis. Certified reference solutions for the composition of aqueous aluminum, indium, magnesium, nickel and titanium
Authors: Ermakova I. I. , Ivanov A. V. , Zyablikova I. N. , Shobina A. N. 
Published: November 2019

This paper presents information on the development and certification of reference materials (CRM) for the composition of aqueous aluminium, indium, magnesium, nickel, and titanium solutions.CRMs are represented by aqueous solutions containing aluminium, indium, magnesium, nickel, and titanium ions. CRMs have been packed into 5, 10 and 25 cm3 glass ampoules, as well as into 50 and 250 cm3 polypropylene vessels. The certified values of metal mass concentrations were established according to the preparation method.The certified value of the mass concentration of metal ions in the CRMs under study is found to vary within the range of 0.95–1.06 g/dm3. Both the relative expanded uncertainty (under k= 2) of the certified mass concentration and the relative standard uncertainty due to instability do not exceed the values of 0.8 % and 0.069 %, respectively. The developed CRMs are shown to have the shelf life of 3 years provided that standard storage conditions are ensured. The developed CRMs are included into the RF State Register of Certified Reference Materials under the following numbers: CRM 11122–2018, CRM 11123–2018, CRM 11124–2018, CRM 11125–2018, and CRM 11126–2018. The CRMs produced by the All-Russian Research Institute for Optical and Physical Measurements (VNIIOFI) are characterized by the values of expanded uncertainty comparable to those of world leaders in the production of similar materials.
REVITALISASI PERAN PERPUSTAKAAN UMUM BAGI MASYARAKAT
Authors: Widuri Noorika Retno 
Published: November 2019

<p>The positive development of the various plans of the central government and local government in revitalizing the function of the library in the middle of the community deserve an immediate response by the relevant stakeholders in librarianship. This avoids the loss of state spending because of the development budget of the library, while the library can not be used optimally by the community. In addition to causing harm to the state budget, the failure of the revitalization of the public library functions have an impact on the loss of public confidence in the library. See some interesting phenomenon, the author argues that it is time the library needs to revitalize its role for the community. The issue raised is how the shape of revitalizing the role of the public library for the community.</p><p>There are several factors driving the revitalization of the role of libraries, namely<br />the advancement of information and communication technologies, the increasing<br />mobility of educated people and high society. The revitalization of the role of public libraries include the library as a social change agent, the agent of human development and cultural agents. Revitalization activities the library’s role as change agents are providing a variety of programs that present a public library, according to the dynamics of today’s society, setting up community-based public library. Revitalize the role of the public library into a public space as a catalyst for social activities, recreation, and culture of the citizens, and to make the library more dynamic, practical and humane. Revitalizing the role of the public library as part of a public service by applying the standard ISO 9008: 2008 in libraries, innovation bureaucracy and library services, as well as professional certification library manager.</p><p>Keywords: revitalization of the library; the role of the library; public Library;<br />agents of social change; public service</p>
Pengaruh Model Kooperatif Tipe TGT (Teams Games Tournament) Terhadap Motivasi Belajar Siswa Kelas 2 Sekolah Dasar
Authors: Mustofiyah Lilis 
Published: November 2019

This study aims to determine the effect of the TGT type cooperative model (Teams Games Tournament) on student learning motivation. Researchers conducted research at SDN Cangkring Turi Prambon. The type of research used is a quantitative approach to experimental methods with Pre Experimental design. The type used is One Group Pretest-Posttest Design. The subjects taken were 21 grade II students at SDN Cangkring Turi Prambon. TGT learning model is used to find out the effect of the TGT learning model on the learning motivation of class II students of SDN Cangkring Turi Prambon. The results of this study indicate that the analysis of the data obtained is tcount of 20.80 and ttable of 1.725. Thus tcount > ttable, namely 20.80> 1.725, there is the effect of the TGT model on the learning motivation of class II students of SDN Cangkring Turi Prambon. While the results of the eta squared test obtained 0.955 ≥ 0.14 has the meaning of great influence.