bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends and Cross-Country Inequalities in Dengue, 1990-2021
Authors: Zhou Mingzhu , He Yong , Wu Liangmiao , Weng Kaiyuan 
Published: December 2024

AbstractBackgroundThe existing body of literature is deficient in the most recent data regarding the global perspective of dengue fever and its associated health inequities.Our aim is to assess the global burden of dengue fever and its health inequities from 1990 to 2021.MethodsWe utilized the Global Burden of Disease (GBD) database for epidemiological trends, demographic analysis, and epidemiological decomposition. Cross-national inequality and predictive modeling for the global dengue burden up to 2051 were also performed.ResultsGlobally, dengue fever incidence, prevalence, DALYs, and mortality showed increasing trends with significant international disparities. From 1990 to 2021, ASR for incidence and prevalence rose by 1.83% (95% CI: 1.58%-2.08%), and for DALYs and mortality by 1.33% (95% CI: 1.10%-1.57%) and 1.70% (95% CI: 1.45%-1.94%), respectively. Age-period-cohort-model analysis revealed a positive correlation between dengue fever incidence and age, with mortality sharply increasing in those over 80. Decomposition of dengue fever DALYs burden showed population growth as the main contributor to the global burden, with varying impacts across SDI quintiles. Inequalities in dengue fever burden related to SDI persisted, shifting benefits from impoverished to affluent populations. BAPC model projections suggest stabilization of incidence and prevalence ASRs, with declining DALYs and mortality ASRs, particularly for females.ConclusionThis study elucidates the changes in the burden of dengue fever against the backdrop of a burgeoning global population, severe aging, and pronounced health inequities across nations, quantifying these alterations and forecasting the trends in the disease burden over the next three decades. Concurrently, the research proposes effective measures for various countries and regions to mitigate health inequities associated with dengue fever and to reduce the associated disease burden.
Group judgments and decision-making in accounting: enhancing the financial reporting judgments of accountants
Authors: Liu Fang , Mala Rajni , Chand Parmod , Dumay John 
Published: December 2024

PurposeInvestors and other stakeholders depend on financial reports prepared by accountants to make informed decisions. During the aftermaths of unprecedented events, such as COVID-19, the need investors have for high-quality financial information is greater than ever. The purpose of this study is to examine whether financial reporting judgments made in groups rather than as individuals result in a better reflection of the economic substance of a transaction.Design/methodology/approachTo examine the benefits that decision-making in groups may have on the reporting judgments of accountants, we conducted an experiment in which experienced accountants, located in Australia, were asked to make a decision over a lease classification. Each of the 87 respondents were either assigned to make their decision individually or as part of a three-member group.FindingsOur results indicate that accountants in groups of three make significantly more accurate judgments than accountants who make judgments individually. The results also support the presumption that accountants in groups are significantly more confident in their judgments than accountants who make judgments individually.Research limitations/implicationsWe contribute to the important discussion that decision-making in groups has the potential to improve the quality of financial reporting by better reflecting economic reality.Originality/valueThis study is one of the first to examine the merits of group judgments and decision-making when interpreting and applying the International Financial Reporting Standards.
Unveiling the nexus of renewable energy, institutional quality and financial development in India’s carbon emission landscape
Authors: Ganie Anam Ul Haq , Khah Arif Mohd , Parvaiz Amir 
Published: December 2024

PurposeThe primary objective of this research is to assess the influence of financial development, institutional quality and renewable energy consumption on India’s carbon emissions.Design/methodology/approachThis study utilises econometric methodologies, specifically the autoregressive distributed lag (ARDL) model and Toda–Yamamoto causality tests, to explore the interplay among renewable and non-renewable energy consumption, financial development, economic growth, institutional quality, trade openness and carbon emissions in India spanning the years 1996–2019.FindingsThe research indicates that in India, greater utilisation of renewable energy, enhanced financial development and improved institutional quality are linked to lower carbon emissions. On the contrary, an escalation in carbon emissions is related to the consumption of non-renewable energy and greater trade openness. The Toda–Yamamoto causality tests reveal one-way causal relationships from institutional quality, financial development, non-renewable energy consumption and economic growth to CO2 emissions. Furthermore, the study identifies reciprocal causation, demonstrating that carbon dioxide emissions influence renewable energy consumption and trade openness.Research limitations/implicationsThis study recommends that forthcoming research expand its focus by integrating more comprehensive indicators such as consumption, production, transport-based CO2 emissions or ecological footprint. Additionally, to bolster the rigour of future inquiries, researchers might consider exploring alternative regression analysis methods like NARDL and STAR.Originality/valueThis study addresses a significant gap in the existing literature by being the first empirical investigation into the effects of renewable energy consumption, institutional quality and financial development on carbon emissions in the Indian economy. Unlike prior research, we consider a comprehensive financial development and institutional quality index, providing a more holistic perspective. This unique approach contributes valuable insights into the environmental challenges faced by the Indian economy, offering a nuanced understanding of the complex dynamics of environmental degradation in this region.
Contact matters: determining the effects of political orientations on satisfaction with the police by contact with the police
Authors: Ferdik Frank , Froggé George , Cooney Mikaela , Smith Hayden P. 
Published: December 2024

PurposePublic willingness to obey the law is partially determined by their satisfaction levels with police job performance. Although numerous studies have researched determinants of citizen satisfaction with the police, to date, none have examined whether political orientations, measured according to voting preferences, share any association with this outcome. No study, moreover, has analyzed if the effects of political orientations vary by contact with law enforcement.Design/methodology/approachQuestionnaire data were collected from a convenience sample of university students to determine whether the effects of political orientations on satisfaction with law enforcement varied by contact with the police.FindingsAmong the total sample, as well as those who had no prior contact with the police, liberal respondents expressed less satisfaction with law enforcers when compared to conservatives. Among those who were either contacted by the police, or who initiated contact, political orientations had no effect on satisfaction. What was significant across all models though was procedural justice.Research limitationsGeneralization attempts are hindered considering the non-probability nature of the sample, while causality can also not be confirmed since data are cross-sectional.Practical implicationsPolice officers must behave in procedurally fair manners when interacting with citizens and engage in community outreach initiatives in order to improve their image across society.Originality/valueFindings offer insight into the conditions under which voting preferences can shape evaluations of the police.
Exploration of viscosity dependent on temperature and Newtonian heating above steady hydromagnetic convective flow in a percolating environment: Soret, Dufour consequences
Authors: Omowaye Adeola John , Aleem Taoqer Ayobami , Adesina Adedayo Naheem , Ayinde Samuel Olukayode 
Published: December 2024

Purpose
The purpose of this research is to investigate the behavior of continuous hydromagnetic convective fluid within a porous medium. In this study, all fluid properties are assumed to remain constant, except for viscosity, which varies inversely with temperature. Additionally, the fluid experiences Newtonian heating, and the effects of the Dufour and Soret phenomena are considered. The study also examines how controlling constants affect the velocity, temperature and concentration profiles.

Design/methodology/approach
The model equations are transformed to ordinary differential equations adopting similarity transformations. The resulting coupled nonlinear differential equations are then solved numerically using the shooting method combined with the fourth order Runge-Kutta (RK-4) technique. The effects of varying parameters on the flow are presented through graphs and tables.

Findings
The consequences of supervising constants on the flow are encapsulated in charts. The findings are that the Biot number is crucial in determining the temperature distribution within a solid during transient heat transfer; a reduction in the velocity chart is experienced as the size of suction grows; the temperature distribution over the upright heated plate escalates dramatically as Dufour(Du) shot up; and a rise in fluid velocity as the Soret parameter increases. The current results are annotated in sketches for better understanding. Findings are authenticated in contrast with published works. Finally, viscosity dependent on temperature and Newtonian heating are crucial in determining the flow characteristics, heat transfer efficiency, pressure drop, flow stability and overall performance of fluid systems. Understanding and accounting for these variations are essential for the optimal design and operation of engineering applications involving fluids.

Originality/value
The peculiarity of the research is perusal of exploration of viscosity dependent on temperature and Newtonian heating above steady hydromagnetic convective flow in a percolating environment: Soret, Dufour consequences. To the best of authors’ understanding, problem like this has not been considered. The findings in this work will give a useful information to scientists and engineers.
Exploration of In Situ Extraction for Enhanced Triterpenoid Production by Saccharomyces cerevisiae
Authors: Dianat Mariam , Straaten Sarah , Maritato Aldo , Wibberg Daniel , Busche Tobias , Blank Lars M. , Ebert Birgitta E. 
Published: December 2024

ABSTRACTPlant‐derived triterpenoids are in high demand due to their valuable applications in cosmetic, nutraceutical, and pharmaceutical industries. To meet this demand, microbial production of triterpenoids is being developed for large‐scale production. However, a prominent limitation of microbial synthesis is the intracellular accumulation, requiring cell disruption during downstream processing. Destroying the whole‐cell catalyst drives up production costs and limits productivity and product yield per cell. Here, in situ product extraction of triterpenoids into a second organic phase was researched to address this limitation. An organic solvent screening identified water‐immiscible isopropyl myristate as a suitable in situ extractant, enabling extraction of up to 90% of total triterpenoids from engineered Saccharomyces cerevisiae. Combining isopropyl myristate and β‐cyclodextrins improved extraction efficiency. In a first configuration, repeated batch fermentation with sequential product extraction and cell recycling resulted in 1.8 times higher production than a reference fermentation without in situ product extraction. In the second configuration, yeast cells were in contact with the second organic phase throughout a fed‐batch fermentation to continuously extract triterpenoids. This resulted in 90% product extraction and an extended production phase. Further improvement of triterpenoid production was not achieved due to microbial host limitations uncovered through omics analyses.
Cost‐effectiveness of first‐line systemic therapies for unresectable hepatocellular carcinoma
Authors: Lian Dai , Gan Yuling , Xiao Dunming , Xuan Dennis , Liu Shimeng , Wei Yan 
Published: December 2024

AbstractAimsTo examine the cost‐effectiveness of first‐line systemic therapies recommended by the National Comprehensive Cancer Network guidelines for Unresectable Hepatocellular Carcinoma (uHCC) from the US social and payer's perspective.MethodsA cost‐effectiveness analysis was conducted using a three‐state partitioned survival model to assess the cost‐effectiveness of atezolizumab plus bevacizumab, tremelimumab plus durvalumab, durvalumab, lenvatinib and sorafenib as first‐line treatments for uHCC. Clinical efficacy was derived from a published network meta‐analysis. Cost and utility inputs were collected from literature. Main outcomes measured were quality‐adjusted life year (QALY), and incremental cost‐effectiveness ratio (ICER). Univariate and probabilistic sensitivity analyses, as well as scenario analyses were performed.ResultsOver a 10‐year time horizon, atezolizumab plus bevacizumab yielded the highest QALYs. Compared to sorafenib, atezolizumab plus bevacizumab, tremelimumab plus durvalumab and lenvatinib had ICERs of $196 704/QALY, $800 755/QALY and $2 032 756/QALY, respectively. Sorafenib was dominated by durvalumab due to lower QALYs and higher costs. At a willingness‐to‐pay threshold of $150 000/QALY, probabilistic sensitivity analysis revealed that durvalumab had a 99.96% probability of providing the highest net monetary benefit.ConclusionsAt a willingness‐to‐pay threshold of $150 000/QALY, durvalumab is likely the most cost‐effective first‐line systemic therapy for uHCC compared to sorafenib. Although atezolizumab plus bevacizumab yielded the highest QALYs, their ICERs exceeded the commonly accepted cost‐effectiveness threshold ($150 000$ per QALY gained). These findings can inform clinical decision‐making, resource allocation and future research priorities in managing uHCC.
Re‐examining cognitive load measures in real‐world learning: Evidence from both subjective and neurophysiological data
Authors: Liu Xiaobo , Zhang Yu 
Published: December 2024

AbstractBackgroundCognitive load theory is widely used in educational research and instructional design, which relies heavily on conceptual constructs and measurement instruments of cognitive load. Due to its implicit nature, cognitive load is usually measured by other related instruments, such as commonly‐used self‐report scales of mental effort or task difficulty. However, these concepts are different in nature, as they emphasize distinct perspectives on cognitive processing. In addition, real‐world learning is more complex than simplified experimental conditions. Simply assuming that these variables will change in a monotonic way with workload may be misleading.AimsThis study aims to examine whether these measures are consistent with each other, and to discover the neurophysiological basis underlying the potential discrepancy.SampleThe study collected data in both a real‐world (Study 1, 22 high school students in 13 math classes) and a laboratory setting (Study 2, 30 students in 6 lab‐based math tasks).MethodsIn addition to self‐report measures, the study also collected multimodal neurophysiological data, such as electroencephalography (EEG), electrodermal activity (EDA), and photoplethysmography (PPG).ResultsThe results show that although the difficulty level can be perceived with difficulty ratings, it does not lead to the corresponding level of mental effort. Only within an appropriate level of load, can we observe a positive correlation between self‐report difficulty and mental effort. Neurophysiological evidence also supports the conceptual discrepancies and group differences, indicating distinct neurophysiological mechanisms underlying these ‘similar’ constructs.ConclusionsThese findings also emphasize the need for combining these concepts to better evaluate students' cognitive load.
A Variable Clinical Presentation of Hemoglobin City of Hope
Authors: Brik Simon Dafna , Filon Dvora , Meiner Vardiella , Krasnov Tanya , Noy‐Lotan Sharon , Dgany Orly , Gilad Oded , Goldberg Tracie , Izraeli Shai , Yacobovich Joanne , Tamary Hannah , Steinberg‐Shemer Orna 
Published: December 2024

ABSTRACTHemoglobin City of Hope (Hb‐COH), NC_000011.9(NM_000518.5):c.208G > A; NP_000509.1:p.(Gly70Ser), has rarely been described. The presentation ranges from asymptomatic heterozygosity to significant anemia in patients carrying an additional pathogenic variant in β‐globin. To elucidate the clinical spectrum of Hb‐COH, we analyzed 31 individuals carrying the variant, including, for the first time, homozygous individuals. Seven patients who were compound heterozygous for Hb‐COH and an additional variant in β‐globin, presented with mild‐to‐severe microcytic anemia and elevated hemoglobin‐A2. Three (43%) of these also had elevated fetal hemoglobin, but none required blood transfusions. Seven patients coinherited Hb‐COH with an ‐α3.7‐deletion (NG_000006.1:g.34247_38050del), their presentation ranged from mild microcytic anemia to normal blood counts. Three homozygous and 14 heterozygous individuals for Hb‐COH had normal blood counts. Most Hb‐COH alleles whose origin was traceable were from Ashkenazi Jews (70.4%). To conclude, while isolated Hb‐COH appears asymptomatic even in the homozygous state, it may cause significant anemia when coinherited with an additional pathogenic variant in β‐globin. Understanding the full impact of Hb‐COH is crucial for optimal patient management and for genetic counseling.
Musical Experience and Speech Processing: The Case of Whistled Words
Authors: Tran Ngoc Anaïs , Meyer Julien , Meunier Fanny 
Published: December 2024

AbstractIn this paper, we explore the effect of musical expertise on whistled word perception by naive listeners. In whistled words of nontonal languages, vowels are transposed to relatively stable pitches, while consonants are translated into pitch movements or interruptions. Previous behavioral studies have demonstrated that naive listeners can categorize isolated consonants, vowels, and words well over chance. Here, we take an interest in the effect of musical experience on words while focusing on specific phonemes within the context of the word. We consider the role of phoneme position and type and compare the way in which these whistled consonants and vowels contribute to word recognition. Musical experience shows a significant and increasing advantage according to the musical level achieved, which, when further specified according to vowels and consonants, shows stronger advantages for vowels over consonants for all participants with musical experience, and advantages for high‐level musicians over nonmusicians for both consonants and vowels. By specifying high‐level musician skill according to one's musical instrument expertise (piano, violin, flute, or singing), and comparing these instrument groups to expert users of whistled speech, we observe instrument‐specific profiles in the answer patterns. The differentiation of such profiles underlines a resounding advantage for expert whistlers, as well as the role of instrument specificity when considering skills transferred from music to speech. These profiles also highlight differences in phoneme correspondence rates due to the context of the word, especially impacting “acute” consonants (/s/ and /t/), and highlighting the robustness of /i/ and /o/.
Investigating Aging‐Related Endometrial Dysfunction Using Endometrial Organoids
Authors: Lu Minghui , Han Yanli , Zhang Yu , Yu Ruijie , Su Yining , Chen Xueyao , Liu Boyang , Li Tao , Zhao Rusong , Zhao Han 
Published: December 2024

ABSTRACTAgeing of the endometrium is a critical factor that affects reproductive health, yet its intricate mechanisms remain poorly explored. In this study, we performed transcriptome profiling and experimental verification of endometrium and endometrial organoids from young and advanced age females, to elucidate the underlying mechanisms and to explore novel treatment strategies for endometrial ageing. First, we found that age‐associated decline in endometrial functions including fibrosis and diminished receptivity, already exists in reproductive age. Subsequently, based on RNA‐seq analysis, we identified several changes in molecular processes affected by age, including fibrosis, imbalanced inflammatory status including Th1 bias in secretory phase, cellular senescence and abnormal signalling transduction in key pathways, with all processes been further validated by molecular experiments. Finally, we uncovered for the first time that PI3K‐AKT‐FOXO1 signalling pathway is overactivated in ageing endometrium and is closely correlated with fibrosis and impaired receptivity characteristics of ageing endometrium. Blocking or activation of PI3K by LY294002 or 740Y‐P could attenuate the effect of ageing or accelerate dysfunction of endometrial organoids. This discovery is expected to bring new breakthroughs for understanding the pathophysiological processes associated with endometrial ageing, as well as treatment strategies to improve reproductive outcomes in women of advanced reproductive age.
Precision of Estimated Growth Parameters of Yellowfin Tuna (Thunnus albacares) From Length‐Frequency Data Estimated by Bootstrapping
Authors: Taufani Wiwiet Teguh , Matsuishi Takashi Fritz 
Published: December 2024

ABSTRACTOver 60% of the world's fish stocks suffer from limited data, which hampers effective fisheries management. Researchers have developed stock assessment methods for data‐limited fisheries using length‐frequency data, but reliability was questionable and not well researched. We evaluated the precision of the widely used length‐based method ELEFAN using 24 months of length‐frequency data from 14,190 individual yellowfin tuna and sequential and interval data fractions. Using bootstrapping (1000 times) and data reduction, growth parameters and precision , , and Φ′ were estimated. The CVs of , , and Φ′ were 2.55%, 23.04%, and 2.35%, respectively. From the result of data reduction, at least once in 1 or 2 months and 12 times measurements with 500 data per measurement on average is recommended for achieving high precision with CV of Φ′ < 3%.