bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pericyte-tumor crosstalk facilitates metastatic tumor cell latency through PIEZO1-activated lysophospholipid transfer
Authors: McErlain Tamara , Glass Morgan J , McCulla Elizabeth C , Madden Caitlin A , Ziemer Lauren E , Overdahl Kirsten E , Jarmusch Alan K , Kruhlak Michael J , Chesler Alexander T , Yang Howard H , Lee Maxwell P , Branco Cristina M , Murgai Meera 
Published: February 2025

AbstractTumor dissemination is increasingly recognized to begin early in tumor development. Although most of these early disseminated cells are cleared, some survive and persist below clinical detection, acting as reservoirs for metastatic relapse. Metastatic tumor cells often rely on interactions with local stromal cells to support their colonization. In this study, we propose that pericyte-tumor cell interactions promote dormancy induction in the early metastatic lung, enhancing disseminated tumor cell (DTC) persistence. Extravital imaging demonstrated that DTCs interact with pericytes upon extravasation into the lung. Co-culture experiments were used to assess DTC fate after pericyte contact and revealed that transient contact with pericytes reduced the proliferation of metastatic 4T1 breast cancer cells but had no effect on non-metastatic 67NR cells.In vivo, transient pericyte contact resulted in higher lung metastatic burden, driven by small, non-proliferative lesions (<6 cells), 10 days after intracardiac injection. These lesions exhibited reduced KI67 staining and EdU incorporation compared to those from monocultured cells. We further observed that primary lung pericytes transferred lyso-phospholipids (lyso-PLs) specifically to metastatic 4T1 cells through direct contact. Gene expression analysis indicated that transient pericyte contact activated pathways related to syncytium formation in metastatic cells. In normal physiology, pericytes act in a syncytium to regulate blood flow via mechanosensitive channels in response to blood pressure changes. We hypothesize that tumor cells exploit these mechanosensitive responses to trigger lyso-PL transfer from pericytes. Supporting this, calcium imaging showed higher calcium activity in pericytes co-cultured with 4T1 cells, and calcium channel inhibitors significantly reduced lyso-PL transfer. Pharmacological activation of pericyte calcium channels induced lyso-PL release, which was subsequently taken up by tumor cells. Conditioned medium from activated pericytes, containing free lyso-PLs, recapitulated the reduced proliferation observed in transient co-culture. Finally, we found our pericyte-induced dormancy signature to be associated with tumor dormancy and distant metastasis free survival latency in breast cancer patients. Together, these findings suggest that early DTCs may exploit pericyte signaling mechanisms to enter dormancy, facilitating their persistence at metastatic sites and contributing to future relapse.
Glutamatergic heterogeneity in the neuropeptide projections from the lateral hypothalamus to the mouse olfactory bulb
Authors: Qi Meizhu , Won Julia , Rodriguez Catherine , Storace Douglas A. 
Published: February 2025

AbstractThe direct pathway from the lateral hypothalamus to the mouse olfactory bulb (OB) includes neurons that express the neuropeptide orexin-A, and others that do not. The OB-projecting neurons that do not express orexin-A are present in an area of the lateral hypothalamus known to contain neurons that express the neuropeptide melanin-concentrating hormone (MCH). We used virally mediated anterograde tract tracing and immunohistochemistry for orexin-A and MCH to demonstrate that the OB is broadly innervated by axon projections from both populations of neurons. Orexin-A and MCH were expressed in each OB layer across its anterior to posterior axis. Both orexin-A and MCH neurons are genetically heterogeneous, with subsets that co-express an isoform of vesicular glutamate transporter (VGLUT). We used high-resolution confocal imaging to test whether the projections from orexin-A and MCH neurons to the OB reflect this glutamatergic heterogeneity. The majority (∼57%) of putative orexin-A axon terminals overlapped with VGLUT2, with smaller proportions that co-expressed VGLUT1, or that did not overlap with either VGLUT1 or VGLUT2. In contrast, only ∼26% of putative MCH axon terminals overlapped with VGLUT2, with the majority not overlapping with either VGLUT. Therefore, the projections from the lateral hypothalamus to the OB are genetically heterogeneous and include neurons that can release two different neuropeptides. The projections from both populations are themselves genetically heterogeneous with distinct ratios of glutamatergic and non-glutamatergic axon terminals.Three Key PointsA direct anterograde projection from orexin-A-expressing neurons in the hypothalamus to the mouse olfactory bulb (OB) was confirmed using virally mediated tract tracing.Orexin-A and melanin-concentrating hormone (MCH), two neuropeptides primarily produced in the lateral hypothalamus are broadly expressed throughout the mouse OB.Approximately 64% of putative orexin-A axon terminals overlapped with vesicular glutamate transporter type 1 (VGLUT1) or type 2 (VGLUT2). In contrast, only 25% of putative MCH axon terminals overlapped with VGLUT2.
Microsporidia infection altersC. eleganslipid levels
Authors: El Jarkass Hala Tamim , Jeon JiHae , Burton Nick O. , Reinke Aaron W. 
Published: February 2025

AbstractMicrosporidia are fungal-related obligate intracellular parasites that infect many types of animals. Microsporidia have exceptionally reduced genomes resulting in limited metabolic capabilities and are thought to be reliant on host metabolism to fuel their own growth. Here, we investigate the impact of microsporidia infection on host lipid metabolism using the nematodeCaenorhabditis elegansalong with its natural microsporidian pathogenNematocida parisii. We show that infection causes an increase in the level ofC. eleganslipid droplet associated lipase, ATGL-1, and a decrease in host fat levels. A mutation that decreases ATGL-1 activity and overexpression of ATGL-1 did not significantly changeN. parisiiinfection levels. Using lipidomics we show thatN. parisiiinfection decreasesC. eleganstriglyceride levels and results in increased ceramides that we speculate are synthesized byN. parisii. Mutations in host genes involved in ceramide synthesis did not significantly change the levels ofN. parisiiinfection. Together these results show that microsporidia can cause changes to lipid metabolism of their hosts, but some individual mutations ofC. eleganslipid enzymes do not alter microsporidian growth.
Rb2Ca2Si2O7: a new alkali alkaline-earth silicate based on [Si2O7]6− anions
Authors: Kahlenberg Volker 
Published: February 2025

Synthesis experiments were conducted in the ternary Rb2O–CaO–SiO2 system, resulting in the formation of a hitherto unknown compound with the composition Rb2Ca2Si2O7, i.e. dirubidium dicalcium pyrosilicate. Single crystals of sufficient size and quality were recovered from a starting mixture with an Rb2O:CaO:SiO2 molar ratio of 2:1:3. The educts were confined in a lid-covered platinum crucible and gradually cooled from 1050 °C at a rate of 0.3 °C min−1 to 800 °C before being finally quenched in air to ambient conditions. The crystal structure was investigated at −80 and 15 °C from single-crystal X-ray diffraction data, with structure determination performed using direct methods. The compound was found to be of orthorhombic symmetry, belonging to the space group Pmmn (No. 59), with a = 5.7363 (6), b = 13.8532 (12), c = 9.9330 (10) Å, V = 789.34 (13) Å3 and Z = 4 (at 15 °C). The final refinement calculations at ambient temperature converged at R1 = 0.030 and wR2 = 0.076 for 773 observed reflections with I > 2σ(I). The silicate anion is based on pyrosilicate units of composition [Si2O7]6− with point-group symmetry m (Cs
). Charge compensation is achieved by the incorporation of rubidium and calcium cations distributed among a total of five independent sites within the asymmetric unit. Two of the nontetrahedrally coordinated cation sites (M4 and M5) are exclusively occupied by calcium cations, which are surrounded by six O atoms in the form of octahedra or trigonal prisms, respectively. The rubidium cations on the M1–M3 sites show more complex coordination environments. The M2 site, for example, is characterized by a tricapped trigonal prism polyhedron. Notably, the M3 site exhibits a 50% population of Ca2+ and Rb+, respectively. The compound shows closer structural resemblances with K2Ca2Si2O7 and can be derived from a hexagonal aristotype with space-group symmetry P63/mmc by displacements of the atoms. The corresponding distortion modes can be classified by certain irreducible representations of the high-symmetry parent phase. Structural investigations were completed by determining the thermal expansion tensor for the temperature interval between −80 and 15 °C.
Study on the model of factors influencing users’ willingness to participate in misinformation purification on the Weibo platform
Authors: Zhao Yueming , Li Gaohui , Mo Zuying 
Published: February 2025

PurposeTo explore the influence factors and pathways of users’ willingness to participate in the misinformation purification process on the Weibo platform. The findings of this study are expected to provide valuable insights that can enhance the self-purification mechanisms for misinformation on Weibo, thereby contributing to the effective misinformation control.Design/methodology/approachThe theoretical framework of the quantitative study is a conceptual model integrated with the theory of planned behavior (TPB), social exchange theory (SET) and co-dependency theory. This model was developed to elucidate the influence factors of users’ willingness to participate in the purification of misinformation on the Weibo platform, the conceptual model was tested and refined through questionnaire surveys, structural equation modeling (SEM) was used to assess its validity and reliability.FindingsThe findings reveal that the attitude toward misinformation purification on the Weibo platform exerts the most significant positive influence on the willingness to engage in such activities. Within the context of this research, community involvement and reciprocity are identified as the factors that have the most substantial positive impact on users’ attitude toward misinformation purification. Conversely, risk perception does not demonstrate a significant influence on users’ attitude toward misinformation purification.Originality/valueTaking the Weibo platform as an example, this is a pioneering study on the investigation and mechanism of social media self-purification on misinformation and proposes a new perspective to improve the effectiveness of the social media self-purification mechanism from the perspective of focusing on user intention and motivation.
Workplace adversity and the dual impact of gender on employee intentions to leave and pursue social entrepreneurship
Authors: Rivas Mendoza Milagros Isabel , Afshar Jahanshahi Asghar , Pulido Joo Luis Alexander , Polas Mohammad Rashed Hasan , Paredes Izaguirre Luis Antonio , Espejo-Chacón Luis Fernando 
Published: February 2025

PurposeThis study explores social entrepreneurship as a viable career path for employees facing hostile workplace conditions in Peru. It examines the gender-specific effects of workplace challenges such as hostility, discrimination and sexual harassment on individuals’ aspirations for career transitions and entrepreneurship.Design/methodology/approachA cross-sectional survey was conducted with 450 Peruvian workers experiencing adverse workplace conditions. Quantitative data analysis was used to evaluate the relationship between perceived workplace challenges, intentions to leave current jobs and the propensity to pursue social entrepreneurship. Gender differences were analyzed to uncover unique patterns in these relationships.FindingsResults reveal significant gender differences: females report higher levels of discrimination, while males report higher perceptions of workplace harassment. Females intending to leave their jobs demonstrated a stronger inclination toward social entrepreneurship compared to their male counterparts. These findings underline the detrimental impact of hostile work environments on employee aspirations and highlight social entrepreneurship as a meaningful career option for individuals seeking to address societal issues.Practical implicationsThis research offers valuable insights for organizations and policymakers, emphasizing the importance of creating equitable work environments. It also underscores the potential of social entrepreneurship to empower individuals disillusioned by conventional workplace structures to drive positive social change.Originality/valueBy elucidating the role of social entrepreneurship as an alternative career path, our study contributes to the growing body of literature on entrepreneurship and social impact, offering valuable insights for both researchers and practitioners aiming to foster more equitable and empowering work environments.
Developing a scale to measure epistemic trust in open educational resources (OERs)
Authors: Pandey Chandra Shekhar , Pandey Shri Ram , Mishra Patanjali , Pandey Shweta 
Published: February 2025

Purpose
The purpose of the study was to develop and validate a scale for measuring epistemic trust in open educational resources (OERs).

Design/methodology/approach
A mixed methods approach was employed, using both qualitative and quantitative methods. The scale development involved several stages, including various iterations of exploratory factor analysis and confirmatory factor analysis (CFA).

Findings
The study resulted in a valid and reliable nine-factor scale for measuring epistemic trust in OERs. These factors are reliability and credibility of information, source competence and expertise, goodwill and intentions of the source, transparency and openness, consistency and stability, accessibility and usability, peer and social validation, engagement and interaction and ethical and moral integrity. The CFA confirmed the nine-factor structure and showed good model fit. Cronbach’s alpha coefficients for the dimensions ranged from 0.668 to 0.823, indicating acceptable to excellent internal consistency. Extracted (AVE) value for each factor indicates the strong convergent validity of the scale.

Research limitations/implications
The study’s focus is on measuring epistemic trust of university students in OERs.

Practical implications
By providing a reliable and valid instrument to measure epistemic trust in OERs, the study provides a practical approach for OER creation, curation and use.

Social implications
The study proposes a framework for combating misinformation by providing a scale to assess the epistemic trust in OERs.

Originality/value
To the best of the authors’ knowledge, this is the first study to develop a comprehensive scale specifically designed to measure epistemic trust in OERs.
Motivating factors for professional women in construction career progression
Authors: Muthambi Langanani , Agumba Justus Ngala , Adebowale Oluseyi Julius 
Published: February 2025

PurposeWomen in Construction (WiC) professionally registered with the engineering and built environment councils in South Africa work in a male-dominated industry. Many of these women end their construction careers in less than five years. This study aims to establish the core motivating factors contributing to sustainable careers for professional WiC, drawing on self-determination theory (SDT) as a theoretical framework. The study contributes to sustainable development goal (SDG) 10, which seeks to reduce inequalities by addressing barriers to gender diversity.Design/methodology/approachA quantitative study was conducted utilising a questionnaire survey distributed to professional WiC. The South African Council for the Project and Construction Management Professions (SACPCMP) facilitated the distribution of the questionnaire. A total of 110 responses were received and analysed using descriptive statistics and exploratory factor analysis to interpret the research data and assess the dimensionality and reliability of the constructs.FindingsThe study revealed that family support, job satisfaction and job promotion are the primary motivating factors for professional WiC to benefit from sustainable careers. These factors are consistent with the psychological needs of autonomy, competence and relatedness as identified by SDT, forming the basis of the study’s theoretical framework.Originality/valueThe study provides an understanding of motivating factors crucial for retaining professional WiC in South Africa’s construction industry. The study leverages SDT to offer strategies for fostering long-term career perseverance among professional WiC. This could inform policies and practices focused on promoting gender diversity, in line with SDG 10’s goal to reduce inequalities and support sustainability in different sectors.
The Workplace Hazards of Stress Bragging: Restoring Organizational Culture Through Positive Psychology
Authors: Singh Kuldeep , Sen Sujoy 
Published: February 2025

Purpose
This study aims to explore the phenomenon of stress bragging and its effects on individual well-being, group dynamics and organisational culture. The authors extend the viewpoint to consider how stress bragging goes beyond the individual, affecting colleagues and the overall work environment.

Design/methodology/approach
The authors use a multi-theory framework, integrating crossover theory (CT), responsibility exchange theory (RET) and positive psychology theory (PST). A concise and focused review of extant literature is conducted, supported by our arguments to discuss the phenomenon. This paper follows the Emerald Viewpoint writing guidelines, which “Covers any paper where content is dependent on the author’s opinion and interpretation. This includes journalistic and magazine-style pieces”, as also mentioned in “Author Guidelines” under “Article classification”.

Findings
While bragging may have some positive effects on performance in organisational settings, stress bragging often leads to increased stress, reduced well-being and a toxic organisational culture, and can be explained under the auspices of CT and RET. The authors highlight the potential of PST-based interventions in mitigating these adverse effects by promoting a supportive work environment.

Practical implications
This study provides directions for strategic and managerial actions on dealing with stress bragging at all levels of the organisation.

Originality/value
This research extends the understanding of stress bragging by exploring its broader implications on organisational culture and well-being. This study also offers fresh insights and mitigating strategies against the adverse effects of stress bragging.
Entrepreneurial leadership for project success through big data capabilities, sustainable resilience and knowledge sabotage behaviour
Authors: Tariq Rabail , Wang Yifan , Latif Khawaja Fawad 
Published: February 2025

PurposeThis paper is drawn on resource-based theory (RBV), dynamic capability theory (DCV) and situational strength theory (SST). It aims to investigate the relationship of entrepreneurial leadership (EL) on project success (PS) through the mediating role of dynamic capabilities (DCs), big data analytic capability (BDAC) and sustainable resilience (SR). It also explores the moderating effect of knowledge sabotage behaviour (KSB) on the relationship of BDAC and SR with PS.Design/methodology/approachData was collected via Questionnaire survey through convenience sampling from the sample of 550 employees working on project in software companies. Of these, 467 response was deemed valid for analysis. The data was analysed using structural equation modelling (SEM) with SMART-PLS tool.FindingsThe study revealed a significant impact of EL on PS (p < 0.05). It also confirmed the significant mediating role of BDAC and SR (p < 0.05) in EL and PS relationship. These findings emphasize that adapting an entrepreneurial leadership style provides an environment conducive to achieving project success. Moreover, the presence of DCs like BDAC and SR enhances the organization adaptability, efficiency and firms’ endurance to disruption and strengthens their ability to navigate challenges and drive firm outcomes.Originality/valueThe research provides valuable insight into the role of EL as a contemporary leadership style in project-based firms that are marked by high risk and uncertainty. Also, this research is the first to examine the role of DCs, i.e. BDAC and SR as essential support in the execution of a project. Moreover, the research also highlights the importance of the effective role of DCs in achieving PS by mitigating the moderating influence of KSB. Thus, these DCs are empirically proven to facilitate EL in-driving project success in volatile environment while avoiding counterproductive work behaviour.
Entrepreneurial orientation and SME growth: the mediating effect of product, process, and business model innovations
Authors: Gameti Daniel , Morrish Sussie 
Published: February 2025

Purpose
This study aims to examine the effect of different types of innovation on the relationship between entrepreneurial orientation (EO) and small to medium enterprise (SME) growth.

Design/methodology/approach
This study used a quantitative approach to collect data from 480 SMEs in Australia and New Zealand through convenience sampling.

Findings
Based on partial least square structural equation modelling, this study found a direct positive relationship between EO and SME growth and an indirect positive relationship between EO and SME growth through business model innovation (BMI). This study emphasised that while SMEs use different types of innovation, they will achieve significant growth by innovating their business models.

Research limitations/implications
The work has some limitations as the focus was on two countries (Australia and New Zealand) considered as developed countries. The result may differ when the study is conducted in developing countries. Also, EO was measured as a unidimensional construct without looking at the individual contributions of the EO dimensions to growth.

Practical implications
SME owner managers seeking growth of their firms must focus their effort on innovating their business models to achieve competitive advantage. Also, SMEs can integrate their product and process innovations in their BMIs to minimise imitation and increase growth.

Originality/value
The novelty of this paper is that while there are existing studies on EO and SME growth, this paper explores the mediating effect of different types of innovation on the relationship between EO and SME growth.