bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reducing Affective Responses to Surgical Images and Videos Through Stylization
Authors: Besançon Lonni , Semmo Amir , Biau David , Frachet Bruno , Pineau Virginie , Sariali El Hadi , Soubeyrand Marc , Taouachi Rabah , Isenberg Tobias , Dragicevic Pierre 
Published: November 2019

AbstractWe present the first empirical study on using colour manipulation and stylization to make surgery images/videos more palatable. While aversion to such material is natural, it limits many people's ability to satisfy their curiosity, educate themselves and make informed decisions. We selected a diverse set of image processing techniques to test them both on surgeons and lay people. While colour manipulation techniques and many artistic methods were found unusable by surgeons, edge‐preserving image smoothing yielded good results both for preserving information (as judged by surgeons) and reducing repulsiveness (as judged by lay people). We then conducted a second set of interview with surgeons to assess whether these methods could also be used on videos and derive good default parameters for information preservation. We provide extensive supplemental material at osf.io/4pfes/.
In vitro comparative analysis of two resonance frequency measurement devices: Osstell implant stability coefficient and Penguin resonance frequency analysis
Authors: Herrero‐Climent Mariano , Falcão Artur , López‐Jarana Paula , Díaz‐Castro Carmen M. , Ríos‐Carrasco Blanca , Ríos‐Santos José Vicente 
Published: November 2019

AbstractAdequate implant stability is an essential requirement. The introduction of the Penguin resonance frequency analysis raises some questions regarding its reliability, reproducibility, and repeatability as well as how it compares to the older Osstell device.PurposeTo assess the newer Penguin implant stability coefficient (ISQ) device (vs the Osstell device).Materials and methodsA total of 120 implants were used, divided into four groups (A, B, C, and D) (according to design) and placed in fresh bovine bone. Consecutive measurements were made with both devices (Penguin/Osstell) with their respective transducers. Then, the ISQ values were measured with the Penguin device using the Osstell transducer, and vice‐versa.ResultsThe mean insertion torque (N/cm) values for the implants were as follows: Group A = 24.7 ± 9.4; Group B = 25.6 ± 9.7; Group C = 28.7 ± 7.9; Group D = 19.1 ± 5.5. The mean ISQ values for the entire sample were as follows: Penguin 67.7 ± 6.1 and Osstell 68.5 ± 9.6. The ISQ value measured with the Penguin device using a SmartPeg transducer was 67.0 ± 8.0, and that for the Osstell device using a MultiPeg transducer was 68.3 ± 7.5. The intraclass correlation coefficient (ICC) was calculated for the ISQ values obtained from both devices and was >0.90 for all transducers. When the ICC transducers were interchanged, the values were <0.77.ConclusionsBoth ISQ devices allow for reliable and repeatable measurement of implant stability; however, the use of each device‐specific transducer is recommended.
Pentamidine inhibits prostate cancer progression via selectively inducing mitochondrial DNA depletion and dysfunction
Authors: Liu Lin , Wang Fan , Tong Yu , Li Lin‐Feng , Liu Yanfeng , Gao Wei‐Qiang 
Published: November 2019

AbstractObjectivesWe investigated the anti‐cancer activity of pentamidine, an anti‐protozoal cationic aromatic diamidine drug, in prostate cancer cells and aimed to provide valuable insights for improving the efficacy of prostate cancer treatment.Materials and methodsProstate cancer cell lines and epithelial RWPE‐1 cells were used in the study. Cell viability, wound‐healing, transwell and apoptosis assays were examined to evaluate the influences of pentamidine in vitro. RNA‐seq and qPCR were performed to analyse changes in gene transcription levels upon pentamidine treatment. Mitochondrial changes were assessed by measuring mitochondrial DNA content, morphology, membrane potential, cellular glucose uptake, ATP production and ROS generation. Nude mouse xenograft models were used to test anti‐tumour effects of pentamidine in vivo.ResultsPentamidine exerted profound inhibitory effects on proliferation, colony formation, migration and invasion of prostate cancer cells. In addition, the drug suppressed growth of xenograft tumours without exhibiting any obvious toxicity in nude mice. Mechanistically, pentamidine caused mitochondrial DNA content reduction and induced mitochondrial morphological changes, mitochondrial membrane potential dissipation, ATP level reduction, ROS production elevation and apoptosis in prostate cancer cells.ConclusionsPentamidine can efficiently suppress prostate cancer progression and may serve as a novel mitochondria‐targeted therapeutic agent for prostate cancer.
The increased risk of microvascular complications in South Asians with type 1 diabetes is influenced by migration
Authors: Chetan M.R. , Miksza J.K. , Lawrence I. , Anjana R.M. , Unnikrishnan R. , Amutha A. , Shanthi Rani C.S. , Jebarani S. , Mohan V. , Khunti K. , Narendran P. 
Published: November 2019

AbstractAimWe aimed to explore the association between South Asian ethnicity and complications of type 1 diabetes, and whether this is affected by migration.MethodsIn this retrospective cohort study, data on diabetes control and complications were obtained for South Asians in India (South AsiansIndia, n = 2592) and the UK (South AsiansUK, n = 221) and white Europeans in the UK (n = 1431). Multivariable logistic regression was used to identify associations between ethnicity and diabetic kidney disease, retinopathy and neuropathy adjusting for age, sex, BMI, disease duration, HbA1c, blood pressure (BP) and cholesterol.ResultsSouth AsiansIndia had significantly greater adjusted odds of diabetic kidney disease [odds ratio (OR) 5.0, 95% confidence intervals (CI) 3.6–7.1] and retinopathy (OR 1.8, 95% CI 1.2–2.5), but lower odds of neuropathy (OR 0.5, 95% CI 0.4–0.6) than white Europeans. South AsiansIndia had significantly greater adjusted odds of diabetic kidney disease (OR 3.0, 95% 1.8–5.3) than South AsiansUK, but there was no significant difference in the odds of other complications.ConclusionsIn this hypothesis‐generating study, we report that South Asian ethnicity is associated with greater risk of diabetic kidney disease and retinopathy, and lower risk of neuropathy than white European ethnicity. Part of the excess diabetic kidney disease risk is reduced in South AsiansUK. These associations cannot be accounted for by differences in vascular risk factors. Our findings in South Asians with type 1 diabetes mirror previous findings in type 2 diabetes and now need to be validated in a study of the effect of ethnicity on type 1 diabetes complications where healthcare is provided in the same setting.
Applying Performance Measures and Process Improvements in the Classroom: The Loch Dots Company Simulation
Authors: Miller Keith E. , Hill Craig , Miller Antoinette R. 
Published: November 2019

ABSTRACTThe article describes a multi‐phase, in‐class simulation that employs problem‐based learning to teach operations and process‐improvement concepts as part of an undergraduate or graduate business course. The simulation is derived from a corporate Lean Six Sigma training activity and has been modified to introduce, demonstrate, and apply a wide range of business concepts relevant to operations and supply chain management, including the use of operational and financial performance measures in decision making. The activity is scalable for small‐ to medium‐size classes with multiple student groups and may be deployed as a stand‐alone, in‐class exercise spread over several class meetings or incorporated into a larger, semester‐long process‐improvement project for multiple student groups. The simulation emphasizes problem‐solving, teamwork, and intra‐firm cooperation in addition to 20–30 other business concepts, tools, and measures that may be incorporated.
Restoration goals: Why are fauna still overlooked in the process of recovering functioning ecosystems and what can be done about it?
Authors: Cross Sophie L. , Bateman Philip W. , Cross Adam T. 
Published: November 2019

SummaryDespite the evidence that fauna play complex and critical roles in ecosystems (e.g. pollination and nutrient cycling) and the knowledge that they need to be considered in restoration, fauna often remain poorly represented in restoration goal setting, monitoring and assessments of restoration success. Fauna clearly are integral to the aspirations of achieving full ecosystem recovery. However, over‐reaching assumptions about the unassisted return of fauna to restored sites, low investment in fauna monitoring, and minimal consideration of the requirements for fauna monitoring in regulatory guidance and standards appear to have led to the historically vegetation‐centric approaches to rehabilitation and ecological restoration. We argue that ecological complexities render assumptions of unassisted fauna return inappropriate in many situations and may represent a missed opportunity to enhance ecological outcomes and improve restoration trajectories. We advocate for greater consideration of fauna as facilitators of ecological restoration and, particularly for well‐funded projects, for monitoring to place greater emphasis on examining the behaviour and resilience of restored fauna communities. There is a clear need for both industry and regulators to recognise that fauna can be crucial facilitators of restoration and appreciate that the return and monitoring of functional faunal communities can be costly, challenging and may require detailed study across a wide range of taxonomic groups. Failure to advance from business as usual models may risk leaving a legacy of ostensibly functional, but biodiversity‐depauperate, restored ecosystems.
Long‐term mortality, disability and stroke recurrence in patients with basilar artery occlusion
Authors: Hawkes M. A. , Blaginykh E. , Ruff M. W. , Burrus T. , Wijdicks E. F. M. , Rabinstein A. A. 
Published: November 2019

Background and purposeThe long‐term outcomes and stroke recurrence after basilar artery occlusion (BAO) are largely unknown. We aimed to assess these variables in a comparatively large series of consecutive patients.MethodsAdults with acute BAO were retrospectively identified from 1976 to 2011. Post‐discharge records were reviewed to assess for stroke recurrences, mortality and disability. Exploratory analysis of survival was carried out using Kaplan–Meier and log‐rank tests. Factors associated with survival time were determined using Cox models.ResultsA total of 86 patients (34% female, median age 72 [interquartile range (IQR), 60–79] years) with a median National Institutes of Health Stroke Scale score of 11 (IQR, 6–27) were included. Twenty‐nine patients (34%) died during the initial hospitalization. Median modified Rankin Scale (mRS) score at discharge among survivors was 4 (IQR, 2.5–5.5). At 1 and 5 years, 70% of survivors ad a mRS ≤3. Seventeen patients had recurrent strokes during the hospitalization and 12 patients had 19 recurrent strokes after discharge. The median survival time was 52 days (IQR, 6–1846). Older age per decade on admission [adjusted hazard ratios (aHR), 1.32; 95% confidence interval (CI), 1.05–1.66, P = 0.02] and a higher mRS at discharge (aHR, 4.48; 95% CI, 2.72–7.39, P < 0.0001) were associated with mortality. Patients who were not treated with any reperfusion therapy had a trend towards reduced mortality (aHR, 0.39; 95% CI, 0.14–1.08, P = 0.07).ConclusionsSurvivors from BAO had severe short‐term functional disability. Most deaths and stroke recurrences occurred within the first year following the initial event. The risk of death was higher in older and more disabled survivors. However, favorable long‐term recovery was possible.
Sociability development in mice with cell‐specific deletion of the NMDA receptor NR1 subunit gene
Authors: Ferri Sarah L. , Pallathra Ashley A. , Kim Hyong , Dow Holly C. , Raje Praachi , McMullen Mary , Bilker Warren B. , Siegel Steven J. , Abel Ted , Brodkin Edward S. 
Published: November 2019

AbstractSocial affiliative behavior is an important component of everyday life in many species and is likely to be disrupted in disabling ways in various neurodevelopmental and neuropsychiatric disorders. Therefore, determining the mechanisms involved in these processes is crucial. A link between N‐methyl‐d‐aspartate (NMDA) receptor function and social behaviors has been clearly established. The cell types in which NMDA receptors are critical for social affiliative behavior, however, remain unclear. Here, we use mice carrying a conditional allele of the NMDA R1 subunit to address this question. Mice bearing a floxed NMDAR1 (NR1) allele were crossed with transgenic calcium/calmodulin‐dependent kinase IIα (CaMKIIα)‐Cre mice or parvalbumin (PV)‐Cre mice targeting postnatal excitatory forebrain or PV‐expressing interneurons, respectively, and assessed using the three‐chambered Social Approach Test. We found that deletion of NR1 in PV‐positive interneurons had no effect on social sniffing, but deletion of NR1 in glutamatergic pyramidal cells resulted in a significant increase in social approach behavior, regardless of age or sex. Therefore, forebrain excitatory neurons expressing NR1 play an important role in regulating social affiliative behavior.
Decoupled erosion of amphibians’ phylogenetic and functional diversity due to extinction
Authors: Oliveira Brunno F. , Scheffers Brett R. , Costa Gabriel C. 
Published: November 2019

AbstractAimIt has been argued that the loss of phylogenetic diversity (PD) from species extinctions will result in concomitant loss of functional diversity (FD). As a result, species extinction undermines not only unique evolutionary history, but also ecosystem function and stability. Using data from > 6,000 amphibian species globally, we assess the potential erosion of PD and FD as a result of extinction.LocationGlobal.Time periodFrom the present day to the next 100 years.Major taxa studiedAmphibians (Anura, Caudata and Gymnophiona).MethodsWe simulated future biogeographical patterns of extinction based on International Union for Conservation of Nature (IUCN) threat status, and estimated the loss of PD and FD accordingly. We used null models to determine the extent to which extinctions may result in disproportional losses of PD and FD relative to random extinction. Using spatial regressions, we tested whether the loss of PD can predict the loss of FD.ResultsAlthough spatial patterns of current amphibian PD and FD were similar, extinctions did not retain this similarity. The magnitude of such a decoupling varied widely in space, with most of the global assemblages losing more FD than PD.Main conclusionThis study challenges the assumption that extinctions should yield comparable loss of PD and FD. Species may not be equivalent in the amount of unique evolutionary history and ecological functions that would be lost if they become extinct. Designing conservation strategies based on a single dimension of biodiversity has the danger of leading to misinformed outcomes.
Microbial community dynamics and their contributions to organic acid production during the early stage of the ensiling of Napier grass (Pennisetum purpureum)
Authors: Yuan XianJun , Dong ZhiHao , Li JunFeng , Shao Tao 
Published: November 2019

AbstractThe study aimed to disclose the microbial community dynamics and their contributions to organic acid production during the ensiling of Napier grass. Napier grass was harvested at the vegetative growth phase and ensiled for 30 days. Three silos were opened after 1, 2, 3, 5, 7, 14, and 30 days of ensiling respectively. The intensive fermentation was observed during the initial stage of ensiling, indicated by lower pH (<4.0) on d 2 of ensiling. Lactic acid (LA) was the primary fermentation product, although acetic acid (AA) concentration rapidly increased and LA/AA concentration gradually decreased after 3 days of ensiling. The ethanol concentration was already 11.8 g/kg DM on d 1 of ensiling and then remained stable until the end of ensiling. Lactococcus was the predominant genus during the initial 2 days of ensiling, and then, it was gradually replaced by Lactobacillus. The increase in ammonia nitrogen and butyric acid concentration after 7 days of ensiling was attributed to the growth of Clostridia, which is favored by the high moisture concentration in the Napier grass. The natural ensiling of Napier grass displayed LA‐type fermentation and was dominated by the fermentation of Lactobacillus and Lactococcus. Lactobacillus is mainly responsible for the LA production during the ensiling of Napier grass.
Reconceiving the Boundaries of Home: The ‘Oikology’ of Ephesians
Authors: Ticciati Susannah 
Published: November 2019

AbstractThis article offers a reading of Ephesians in repair of a modern liberal inclusivism that unwittingly perpetuates an oppressive colonialist logic. It delineates the dynamic of dwelling, building and inhabitation present in Ephesians via the oik‐ root, coining the term ‘oikology’ to capture its inseparable economy and ecology. Willie James Jennings is a key dialogue partner in the articulation of the colonialist logic to be overcome. The particular species of modern inclusivism in view is that which is exhibited by New Testament scholars associated with the New Perspective on Paul, which I argue remains captive to a supersessionist logic. The article offers a non‐supersessionist reading of Ephesians, arguing that Israel, rather than being replaced, remains the wider habitat in which the gentile Ephesians find their home. In this way the article seeks a reading of the cosmic Christology of Ephesians as an instantiation not of colonial inclusivism but of true catholicity.
The Patience of God the Creator: Reflections on Genesis 1:1–2:4a
Authors: Jones Paul Dafydd 
Published: November 2019

AbstractThis article proposes that Genesis 1:1–2:4a be read in terms of an exercise of divine patience – an act of ‘letting be’ and ‘letting happen’ wherein God establishes, guides, waits on and endorses the free action of non‐human creatures. It first articulates a doctrine of creatio ex nihilo, affirming that God is solely responsible for the establishment of a dynamic, complex and valuable cosmos. Next, it contends that God's creative efforts include the empowerment of non‐human creatures who reward God's patience and commit themselves to the task of creatio cooperativa. It then argues that the emergence of human beings is a creative act undertaken by God and non‐human creatures, such that the human bears both the imago dei and the imago mundi. In conclusion, the article considers the relationship of divine and human action, the limits of the idiom of causality, and the possibility of developing a doctrine of creation in light of the witness of the Hebrew Bible.
2020 Vision – The Year of the Nurse and Midwife
Authors: Howard Catton 
Published: November 2019

AbstractThe World Health Organization has designated 2020 as the Year of the Nurse and Midwife. With a predicted shortfall of more than nine million nurses and midwives by 2030, the World Health Organization has recognized the urgency of tackling the approaching workforce issues head on. The activities planned should provide a once in a generation opportunity to promote the nursing profession and address crucial issues, such as recruitment and retention, professional development and pay and conditions. The International Council of Nurses is working closely with its National Nursing Associations around the world and other key nursing and health organizations, to create a long‐lasting legacy that will raise the profile of the profession with the public, boost its professional status, and make it sustainable in the future.
Sessile rotifers (Rotifera) exhibit strong seasonality in a shallow, eutrophic Ramsar site in Mexico
Authors: Jiménez‐Santos Marco Antonio , Sarma S. S. S. , Nandini S. , Wallace Robert L. 
Published: November 2019

AbstractTo better understand the sessile rotifer community of a shallow, eutrophic lake, we monitored over a 1‐year period the monthly changes in the density and diversity of rotifers on the roots of the common water hyacinth,Eichhornia crassipes, which served as a representative hydrophyte. Selected physical and chemical parameters of the water were also determined. Mean annual density of all sessile species was 630 individuals per ml. Species of Collothecacea (n = 7) were most abundant. Of the 12 species of Flosculariaceae (Flosculariidae),Sinantherina socialisoccurred seasonally, whilePtygura beauchampiwas most common across all seasons. The Shannon–Wiener diversity index was highest (H′ = 2.8) in April, but decreased in January (H′ = 1.3). Applying the concept of the guild ratio (functional‐based analysis) we found that raptorial species (Collothecacea) were dominant over most of the year (June–February), while microphagous Flosculariidae were dominant during the warm, drier season (March–May). BEST (optimal matching of biota to environment, including stepwise search) analysis and canonical correspondence revealed that temperature, dissolved oxygen, pH, turbidity, and transparency strongly influenced sessile rotifer dynamics. We also found significant correlations between the density of some species and physicochemical variables. These species includedCollotheca ambigua,C. coronetta,C. ornata,C. campanulata,C. tenuilobata, andStephanoceros millsiiin the Collothecacea; andBeauchampia crucigere,Limnias melicerta,L. ceratophylli,Ptygura crystallina,P. melicerta, andSinantherina ariprepesin the Flosculariidae. Our study shows that the communities of sessile rotifers were structured by abiotic factors and that the guild ratio is useful for understanding the relationship between sessile rotifers and their substrata.
Tolerance to salinity and thermal stress by larvae and adults of the serpulid annelid Ficopomatus enigmaticus
Authors: Peria Jessica , Pernet Bruno 
Published: November 2019

AbstractThe serpulid annelid Ficopomatus enigmaticus is a widely distributed invader of shallow‐water, brackish habitats in subtropical and temperate regions, where it has numerous damaging ecological and economic effects. Its distributional pattern suggests that temperature and salinity play important roles in limiting its distribution, but because other factors often covary with these, drawing strong conclusions from these patterns is difficult. In an effort to more clearly identify the effects of these factors, we examined tolerance to acute thermal (16–28°C) and salinity (0–35 psu) stress by larvae (5‐day exposure, unfed) and adults (14‐day exposure, unfed) of F. enigmaticus in the laboratory experiments. Larvae showed higher mortality at the highest temperature tested 28°C; adult survival was unaffected by temperature. Neither larvae nor adults survived exposure to pure freshwater (0 psu), but survived well at salinities ranging 3.5–35 psu. In addition, high salinity did not slow tube growth in adults. These results suggest that salinity stress, in particular, does not directly limit the distribution of F. enigmaticus to low‐salinity habitats. Experimental work on the distribution of F. enigmaticus is uncommon in the literature, but is likely needed to identify the abiotic or biotic factors that limit the distribution of this frequently invasive species.