bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome Prediction of Higher-Risk Brief Resolved Unexplained Events
Authors: DeLaroche Amy M. , Haddad Rita , Farooqi Ahmad , Sapién Robert E. , Tieder Joel S. 
Published: April 2020

OBJECTIVES:
Brief resolved unexplained events (BRUEs) are classified as higher risk on the basis of patient and event characteristics, but there is limited evidence to guide management decisions. The authors of this study aim to describe patients with a higher-risk BRUE, determine the yield of diagnostic evaluation, and explore predictors of clinical outcomes.

METHODS:
A retrospective medical record review was conducted for patients ≤365 days of age who were evaluated in a tertiary-care pediatric emergency department with a discharge diagnostic code indicative of a BRUE. Demographic and clinical characteristics, including diagnostic evaluation, are reported. Univariate and multivariate analyses were used to test the association of risk factors with clinical outcomes (serious underlying diagnosis, recurrent events, and return hospitalization).

RESULTS:
Of 3325 patients, 98 (3%) met BRUE criteria and 88 were classified as higher risk; 0.6% of laboratory and 1.5% of ancillary tests were diagnostic, with 4 patients having a serious underlying diagnosis. Nine patients had recurrent events during hospitalization, and 2 were readmitted for a recurrent BRUE after their index visit. Prematurity was the only characteristic significantly associated with an outcome, increasing the odds of a recurrent event (odds ratio = 9.4; P = .02).

CONCLUSIONS:
The majority of patients with a BRUE are higher risk, but the yield of diagnostic evaluation is low. Published risk criteria do not appear to be associated with adverse clinical outcomes except for prematurity and recurrent events. Future multicentered prospective studies are needed to validate risk stratification and develop management guidance for the higher-risk BRUE population.
Variation in Proportion of Blood Cultures Obtained for Children With Skin and Soft Tissue Infections
Authors: Stephens John R. , Hall Matt , Markham Jessica L. , Zwemer Eric K. , Cotter Jillian , Shah Samir S. , Brittan Mark S. , Gay James C. 
Published: April 2020

OBJECTIVES:To identify variation in the proportion of blood cultures obtained for pediatric skin and soft tissue infections (SSTIs) among children’s hospitals.METHODS:We conducted a retrospective cohort study using the Pediatric Health Information System database, which we queried for emergency department (ED)–only and hospital encounters between 2012 and 2017 for children aged 2 months to 18 years with diagnosis codes for SSTI. The primary outcome was proportion of SSTI encounters during which blood cultures were obtained. Encounters with and without blood cultures were compared for length of stay, costs, and 30-day ED revisit and readmission rates, adjusted for patient factors and hospital clustering. We also identified encounters with bacteremia using billing codes for septicemia and bacteremia.RESULTS:We identified 239 954 ED-only and 49 291 hospital SSTI encounters among 38 hospitals. Median proportions of ED-only and hospital encounters with blood cultures were 3.2% (range: 1%– 11%) and 51.6% (range: 25%–81%), respectively. Adjusted ED-only encounters with versus without blood culture had higher costs ($1266 vs $460, P &lt; .001), higher ED revisit rates (3.6% vs 2.9%, P &lt; .001), and higher admission rates (2.0% vs 0.9%, P &lt; .001). Hospital encounters with blood culture had longer length of stay (2.3 vs 2.0 days, P &lt; .001), higher costs ($5254 vs $4425, P &lt; .001), and higher readmission rates (0.8% vs 0.7%, P = .027). The overall proportion of encounters with bacteremia was 0.6% for ED-only encounters and 1.0% for hospital encounters.CONCLUSIONS:Despite multiple studies in which low clinical value was demonstrated and current Infectious Diseases Society of America guidelines arguing against the practice, blood cultures were obtained frequently for children hospitalized with SSTIs, with substantial variation across institutions. Few bacteremic encounters were identified.
Parent Perceptions About Communicating With Providers Regarding Early Autism Concerns
Authors: Locke Jill , Ibanez Lisa V. , Posner Elyanah , Frederick Lindsay , Carpentier Pascale , Stone Wendy L. 
Published: April 2020

BACKGROUND:
Long delays between parents’ initial concerns about their children’s development and a subsequent autism spectrum disorder (ASD) diagnosis are common. Although discussions between parents and providers about early ASD concerns can be difficult, they are critical for initiating early, specialized services. The principles of shared decision-making can facilitate these discussions. This qualitative study was designed to gain insights from parents of young children with ASD about their experiences communicating with primary care providers with the goal of identifying strategies for improving conversations and decision-making regarding the early detection of ASD.

METHODS:
Three 2-hour focus groups were conducted with 23 parents of children with ASD &lt;8 years old. Qualitative analysis employed an iterative and systematic approach to identify key themes related to parents’ experiences.

RESULTS:
Eight themes related to communication about early ASD concerns emerged: characteristics of the child that caused parental concerns, the response of others when the parent brought up concerns, how concerns were brought up to the parent by others, parental responses when others mentioned concerns, information seeking, barriers to and facilitators of acting on concerns, and recommendations to providers. Parent responses suggest the need for increased use of shared decision-making strategies and areas for process improvements.

CONCLUSIONS:
Primary care providers can play a key role in helping parents with ASD concerns make decisions about how to move forward and pursue appropriate referrals. Strategies include responding promptly to parental concerns, helping them weigh options, and monitoring the family’s progress as they navigate the service delivery system.
Tubular STAT3 Limits Renal Inflammation in Autosomal Dominant Polycystic Kidney Disease
Authors: Viau Amandine , Baaziz Maroua , Aka Amandine , Mazloum Manal , Nguyen Clément , Kuehn E. Wolfgang , Terzi Fabiola , Bienaimé Frank 
Published: April 2020

Significance Statement
Recent research into the pathophysiology of autosomal dominant polycystic kidney disease indicates that both signaling of primary cilia of tubular cells and immune cell infiltration play key roles. However, the reciprocal interactions between immune and tubular cells are not well characterized. The transcription factor STAT3, an important modulator of inflammatory response and a cilia component, is activated in polycystin 1 (PKD1)–deficient tubular cells and is suspected to promote cyst growth. In this work, the authors used murine models involving postdevelopmental ablation of Pkd1, Stat3, and cilia to assess STAT3’s role in the disease. They found that, contrary to previous assumptions, STAT3 does not appear to be a critical mediator of cyst growth, but instead acts in a feedback loop that restricts cilia-dependent renal inflammation by repressing proinflammatory cytokines.

Background
The inactivation of the ciliary proteins polycystin 1 or polycystin 2 leads to autosomal dominant polycystic kidney disease (ADPKD). Although signaling by primary cilia and interstitial inflammation both play a critical role in the disease, the reciprocal interactions between immune and tubular cells are not well characterized. The transcription factor STAT3, a component of the cilia proteome that is involved in crosstalk between immune and nonimmune cells in various tissues, has been suggested as a factor fueling ADPKD progression.

Method
To explore how STAT3 intersects with cilia signaling, renal inflammation, and cyst growth, we used conditional murine models involving postdevelopmental ablation of Pkd1, Stat3, and cilia, as well as cultures of cilia-deficient or STAT3-deficient tubular cell lines.

Results
Our findings indicate that, although primary cilia directly modulate STAT3 activation in vitro, the bulk of STAT3 activation in polycystic kidneys occurs through an indirect mechanism in which primary cilia trigger macrophage recruitment to the kidney, which in turn promotes Stat3 activation. Surprisingly, although inactivating Stat3 in Pkd1-deficient tubules slightly reduced cyst burden, it resulted in a massive infiltration of the cystic kidneys by macrophages and T cells, precluding any improvement of kidney function. We also found that Stat3 inactivation led to increased expression of the inflammatory chemokines CCL5 and CXCL10 in polycystic kidneys and cultured tubular cells.

Conclusions
STAT3 appears to repress the expression of proinflammatory cytokines and restrict immune cell infiltration in ADPKD. Our findings suggest that STAT3 is not a critical driver of cyst growth in ADPKD but rather plays a major role in the crosstalk between immune and tubular cells that shapes disease expression.
Profil model mental siswa sekolah menengah atas tentang konsep sel
Authors: Agustina Siti Komariah , Rahman Taufik , Hamdiyati Yanti 
Published: April 2020

The concept of cell is one of material that is quite complicated because it contains abstract concepts such as cell organelles and the mechanism of transport of substances. This study aims to identify the mental models of high school students about the concept of cells represented in written, oral, and picture forms. The method used is descriptive method. In this research, the method use to find mental model of senior high school studets in cells subject. The students are given diagnostic test, as multiple choice, visual test, and oral test which used as students’ mental model parameter. Majority grade XI students of science in senior high school have scientific model, in other words written ideas which refer to the concept with scientific understanding or have basic theory. It can be find in the result: 40% scentific for writing test, 53% scientific for oral test, and 40% scientific for drawing test. Whereas, grade XI students of science in private high school, the students have experience model which shows from their reprecentation which based on analogy. It can be find in the result: 42% experience for writing test, 57% experience for oral test, and 42% experience for drawing test.
The Effect of Cooperative Learning Intentionally Structuring Model on Self-Disclosure and Self-Awareness in Physical Education Learning at School
Authors: Stiadi Dendy , Ma'mun Amung , Juliantine Tite 
Published: April 2020

Physical education is one of the subjects at schools that can make a significant contribution to students’ interpersonal aspect and social. One of the main aspects in developing a change in attitude is self-disclosure and self-awareness. The purpose of this study was to find out how influential the cooperative learning intentionally structuring model on self-disclosure and self-awareness in Physical Education learning at school. The method used in this study was an experimental method with a pretest-posttest control group research design. The sample in this study were 60 students of class 10 (X) from SMK N 12 Bandung divided into 2 groups by using purposive sampling techniques. The instrument used to measure self-disclosure was ESDS (emotional self disclosure scale). Meanwhile, to measure self-awarness, the self awareness scale was used. Data analysis process used SPSS version 21 with Paired Sample T-Test for hypothesis testing. The results of the analysis and calculation of the data revealed that there were significant changes between the cooperative learning intentionally structuring learning model group and the control group. It showed that giving an explanation, or intentionally structuring, to the experimental group during physical education learning could affect the increase in the experimental group far above the control group. AbstrakPendidikan jasmani merupakan salah satu mata pelajaran di sekolah yang dapat memberikan kontribusi signifikan terhadap siswa antar pribadi dan pembangunan social ). Salah satu yang utama dari pengembangan perubahan sikap yaitu keterbukaan diri dan kesadaran diri. Tujuan dalam penelitian ini untuk mengetahui seberapa berpengaruh model pembelarajan cooperative learning intentionaly structuring terhadap keterbukaan diri dan kesadaran diri dalam pembelajaran penjas di sekolah. Metode yang digunakan dalam penelitian ini adalah experiment dengan desain penelitian pretest-posttest control group design. Sampel dalam penelitian ini berjumlah 60 siswa kelas 10 (X) di SMK N 12 Bandung yang di bagi kedalam 2 kelompok dengan mengunakan tehnik purposive sampling. Instrument yang digunakan menggunakan Instrument emotional self disclosure scale (ESDS) dan Instrument self awareness scale. Analisis data menggunakan SPSS versi 21 dengan pengujian hipotesis mengunakan Paired Sample T-Test. Hasil analisis dan perhitungan data mengungkapkan bahwa terdapat perubahan yang signifikan antara kedua kelompok model pembelajran cooperative learning intensionaly structuring dan kelompok control, dengan memberi penjelasan atau intentionally structuring kelompok eksperimen saat pembelajaran pendidikan jasmani sehingga mendapat peningkatan jauh di atas kelompok control.
Silviano Santiago: elogio e crítica a Lévi-Strauss, ou Lévi-Strauss como texto e bom pretexto
Authors: Katri Moritz Schwarcz Lilia 
Published: April 2020

Este texto analisa o livro de Silviano Santiago, Uma literatura nos trópicos, que completou quarenta anos em 2018, consolidando sua vocação como um “livro de formação”. O ensaio procura acompanhar os diversos capítulos da obra e assim destacar o conceito de “entre-lugar”, gerado, segundo o próprio autor, a partir do caos experimental-existencial do escritor brasileiro e do seu atravessamento entre o discurso das metrópoles e aquele da produção colonial. O texto objetiva ainda mostrar como, no andamento da obra, a figura de Claude Lévi-Strauss ocupa espaços diversos. Se o etnólogo do primeiro capítulo é o herói de Tristes trópicos, já o antropólogo do último texto de Uma literatura nos trópicos é aquele de Estruturas elementares do parentesco e do amplo projeto intitulado de Mitológicas que, nesse caso, comporta-se como grande “adversário” estrutural.
Cinética de congelamento para crioconservação de sementes de amendoim, variedade BR1
Authors: Silva Virgínia Mirtes De Alcântara , Cavalcanti Mata Mario Eduardo Rangel Moreira 
Published: April 2020

<p class="normal">A criopreservação dos materiais biológicos a baixas temperaturas tornou-se um dos pilares da conservação, permitindo o aprimoramento genético e manutenção da viabilidade de espécies. Assim, a criopreservação pode ser definida como a conservação de material biológico a temperaturas abaixo de -130ºC, podendo-se usar temperaturas menores, existentes em balcões criogênicos que chegam a temperatura de -150ºC; ou no vapor do nitrogênio líquido (-170ºC) e em imersão no nitrogênio líquido (-196ºC); permitindo que a crioarmazenagem do material biológico tenha um tempo ilimitado de conservação, ou por tempo ainda não definido pela ciência. Esta pesquisa teve como objetivo determinar as curvas de congelamento do Amendoim BR1 às temperaturas de -20ºC,-50ºC,-100ºC e -150ºC. Foi desenvolvido um sistema de aquisição de dados utilizando microtermopares cuja faixa de temperatura mensurável foi de -170 a +180 ºC, com precisão de ±0,5ºC, permitindo, automatizar e controlar o tempo de gravação de dados. A análise dos dados foi realizada no software Matlab, utilizando regressão não-linear através do método Gauss-Newton, cujos modelos matemáticos são baseados na equação de transferência de calor de Fourier. A partir da obtenção dos dados experimentais e de seu comportamento cinético foi possível determinar a difusividade térmica efetiva da semente de amendoim, cuja variação foi de 0,8 a 2,66 mm2/s, a energia de ativação encontrada foi de 1,03kJ a 1,93kJ. De acordo com os resultados obtidos verifica-se que o modelo proposto por Cavalcanti-Mata é o que melhor representa o comportamento cinético do criocongelamento das sementes de amendoim, tendo em vista que o erro médio relativo P(%) foi inferior a 10% em todas as temperaturas, como, também, obteve o maior coeficiente de determinação R<sup>2</sup>. Também foi demonstrado que a energia livre de Gibbs diminui com o decréscimo de temperatura, variando de 33,63kJmol<sup>-1</sup> a 16,82kJmol<sup>-1</sup>, conforme a temperatura é reduzida.</p>
El derecho cooperativo y el docente cooperativo
Authors: Yorg José Alberto , Ramírez Zarza Ana María 
Published: April 2020

La falta de un marco regulatorio claro y completo para los/as docentes cooperativos/as, trabajadores de la educación cooperativa en el ámbito formal del sistema educativo, como especialidad o modalidad específica y reconocida por ley, constituyen una de las principales causas de preocupación y cuya ocupación es reflejada por este artículo. Esto plantea, con todo rigor, un estudio exhaustivo para luego impulsar con vigor necesario la necesidad de la creación de la figura legal del «docente cooperativo ». Corresponde, a nuestro juicio, al Derecho cooperativo dar los primeros pasos en la consecución de ello. Al igual que el legislador curioso observa determinada actividad humana y la plasma en una normativa que la regula y la legaliza, tal procedimiento puede alcanzar la creación de la figura del «docente cooperativo».Recibido: 08 agosto 2019Aceptado: 25 febrero 2020Publicación en línea: 01 abril 2020
Crítica del derecho popular y derecho de juristas = Critique of people´s law and jurist´s law
Authors: Friedrich Puchta Georg 
Published: April 2020

Kritik von Georg Beseler´s Volksrecht und Juristenrecht, publicado originariamente en los Jahrbücher für wissenschaftliche Kritik, I, 1844, pp. 1–40. Traducción de Joaquín Garrido Martín
Gestão e Controlo da Asma em Países de Expressão Portuguesa
Authors: Nunes Ana Beatriz , Oliveira Ana Pinto de , Jamanca Aua , Brito Duarte Vital , Silva Nádia Mendes da , Duarte Sara , Coelho Anabela 
Published: April 2020

Introdução: A asma atinge mais de 339 milhões de pessoas mundialmente. Na Comunidade dos Países de Língua Portuguesa, em 2016, a sua prevalência variou entre 9,15% (Portugal) e 3,91% (Brasil). Os programas de gestão da doença crónica pretendem melhorar o estado de saúde de doentes com doença crónica e reduzir os custos associados. O objetivo deste estudo é identificar modelos de ‘gestão e controlo da asma’ implementados na Comunidade dos Países de Língua Portuguesa, analisando-os através do modelo de gestão integrada de doença.Material e Métodos: Realizou-se uma revisão rápida da literatura científica indexada na PubMed, e de literatura cinzenta sobre ‘gestão e controlo da asma’ nos países da Comunidade dos Países de Língua Portuguesa.Resultados: Portugal, Brasil e Moçambique apresentaram publicações sobre ‘gestão e controlo da asma’, em diferentes fases de implementação dos programas. A gestão clínica e organização e prestação de cuidados são as dimensões mais abordados nas publicações.Discussão: A implementação de programas de gestão e controlo da asma é influenciada pelos sistemas de saúde, estruturas de prestação de cuidados em que se inserem, meio político e social envolventes. As dimensões do financiamento e dos sistemas de informação são as mais difíceis de implementar, dado o desenvolvimento económico, social e tecnológico da maioria dos países em estudo.Conclusão: Apenas Portugal, Brasil e Moçambique adotaram a gestão integrada de doença da asma como principal forma de gestão e controlo da asma. Os programas desenvolvidos por estes países podem servir de modelo nos restantes países em estudo.
Karakterisasi dan Laju Biodegradasi Biokomposit Serbuk Tulang Sapi/Shellac/Tepung Tapioka sebagai Material Pengisi Tulang
Authors: Triyono Joko , Tantomo Christiawan Bhorin , Masykur Abu 
Published: April 2020

Hasil RISKESDAS menyatakan kasus patah tulang di Indonesia cukup tinggi untuk setiap tahunnya akibat dari kecelakan, jatuh, dan trauma benda tumpul. Salah satu metode penyelesaian dari patah tulang adalah dengan melakukan implan material bone filler dengan komponen dasarnya adalah hidroksiapatit. Tujuan dari penelitian ini adalah untuk mengetahui apakah tepung tapioka dan shellac akan hilang setelah proses sintering, dan mengetahui pengaruh tepung tapioka pada pembentukan porusitas dan degradasi pada material biokomposit BHA. Penelitian ini menggunakan metode kalsinasi untuk menghilangkan zat organik pada serbuk tulang sapi, kompaksi untuk membentuk sebuah tablet biokomposit BHA/<em>Shellac</em>/Tapioka, dan proses sintering untuk menghasilkan porusitas pada tablet spesimen uji. Berdasarkan hasil analisis data uji yang dilakukan, dapat disimpulkan bahwa pengamatan SEM memperlihatkan porusitas yang terjadi pada spesimen uji. Pengamatan pola difraktogram XRD menunjukkan 2θ nilai sampel sesuai dengan pola difraktogram standar HA JCPDS 9-432. Pengamatan spektrum FTIR menunjukkan adanya tiga titik puncak utama yang berupa gugus fungsi fosfat ( ), karbonat ( ) dan hidroksil (OH<sup>-</sup>). Dari ketiga pengamatan tersebut menunjukkan bahwa kandungan tapioka dan shellac telah hilang sepenuhnya saat proses sintering dan hanya menyisakan kandungan BHA dan semakin banyak campuran tapioka yang digunakan akan mempercepat laju degradasi.
Analisis Faktor-Faktor yang Mempengaruhi Tingkat Kelelahan pada Pekerjaan Berulang di Industri Manufaktur
Authors: Septiari Renny 
Published: April 2020

<p>Pekerjaan yang dilakukan dengan duduk secara terus menerus dapat menyebabkan gangguan kesehatan yang lama kelamaan dapat menimbulkan ketidaknyamanan yang pada akhirnya timbul penyakit. Dari beberapa faktor yang mempengaruhi tingkat kelelahan yang ditentukan oleh posisi kerja yang dipengaruhi oleh shift kerja, beban kerja, dan lingkungan kerja fisik akan dianalisa faktor apakah yang paling berpengaruh terhadap pekerjaan pengepakan yang hanya dilakukan dengan duduk sepanjang waktu. Tujuan dari penelitian ini adalah analisis faktor-faktor yang mempengaruhi tingkat kelelahan pada pekerjaan berulang yang dilakukan dengan duduk. Hasil analisa dengan bantuan program <em>SmartPLS</em> menunjukkan bahwa faktor yang berpengaruh dari masing-masing variabel yang diujikan yaitu variabel shift kerja indikator yang berpengaruh adalah waktu kecepatan pengepakan shift sore, variabel beban kerja adalah denyut jantung dan variabel lingkungan kerja fisik adalah pencahayaan. Sedangkan variabel yang berpengaruh terhadap tingkat kelelahan adalah shift kerja yang berpengaruh positif dan signifikan.</p>