bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemSpectra: A Web-based Spectra Editor for Analytical data
Authors: Huang Yu-Chieh , Tremouilhac Pierre , Nguyen An , Jung Nicole , Bräse Stefan 
Published: July 2020

Abstract
ChemSpectra, a web-based software to visualize and analyze spectroscopic data, integrating solutions for IR (infrared spectroscopy), MS (mass spectrometry), and one dimensional 1H and 13C NMR (proton and carbon nuclear magnetic resonance) spectroscopy, is described. ChemSpectra serves as work instrument for the analysis of the most often used types of one dimensional spectroscopic data in synthetic (organic) chemistry research. The software is able to deal with the open file formats JCAMP-DX (IR, MS, NMR) and mzML (MS), allowing the further extension to other formats as exemplarily shown for selected proprietary mass spectrometry data files of type RAW and NMR spectra files of type FID. The JavaScript based editor can be integrated with other software, which was shown for the Chemotion electronic lab notebook (ELN) and Chemotion repository, demonstrating the implementation to a digital work environment that offers additional functionality and sustainable research data management options. ChemSpectra supports different functions for the work with spectroscopic data such as zoom functions, peak picking and the automatic peak detection according to a default or manually defined threshold. NMR specific functions include the definition of a reference signal, the integration of signals, coupling constant calculation and multiplicity assignment. Embedded to a web application such as an ELN or a repository, the editor additionally allows the association to a sample and a file management. The file management supports the storage of the original spectra along with the last edited version and an automatically generated image of the spectra in png format. To maximize the benefit of the spectra editor for e.g. ELN users, an automated procedure for the transfer of the detected or manually chosen signals to the ELN was implemented. ChemSpectra is released under the AGPL license to encourage its re-use and further developments by the community.
Anesthesia for an emergency gastrorrhagia operation in a patient suspected with COVID-19: a case report
Authors: Chen Yu , Lv Hao 
Published: July 2020

Abstract
BackgroundThe spread of the Coronavirus Disease 2019 (COVID-19) in China since December 2019 was very grave. According to Chinese govenment's guidelines, patients can be divided into confirmed cases and suspected cases. The protective measures for both are the same.Case summaryWe report a case of an emergency gastrorrhagia operation for a patient suspected to have contracted COVID-19. A 54-year-old man with massive gastric hemorrhage was scheduled for an emergency operation for exploratory hemostasis. COVID-19 infection, however, could not be ruled out, and the patient was treated as a suspected case. All the protective measures were based on patients infected or suspected to be infected with COVID-19. Before the operation, we carried out a series of protective measures, such as preparing the operating room and wearing personal protective gear. We increased the dose of neuromuscular blocking agents during the induction of anesthesia to prevent the splashing of secretions by coughing. The operation went smoothly, and the patient was transferred to an intensive care unit (ICU) in the isolation ward for extubation. Seven days later, the patient was ruled out for COVID-19 infection. ConclusionThe patient recovered successfully from the massive gastric hemorrhage, and the medical staff were not infected.
Intraventricular synchronism assessment by gated - SPECT myocardial perfusion imaging in cardiac resynchronization therapy. Does cardiomyopathy type influence results?
Authors: Peix Amalia , Padrón Kenia , Cabrera Lázaro O. , Castañeda Osmín , Milán Danet , Castro Jesús , Falcón Roylan , Martínez Frank , Rodríguez Lydia , Sánchez Jesús , Mena Erick , Carrillo Regla , Fernández Yoel , Escarano Ricardo , Páez Diana , Dondi Maurizio 
Published: July 2020

Abstract
Purpose: To analyse the evolution post-cardiac resynchronization therapy (CRT) in left ventricular non-compaction (LVNC) cardiomyopathy (CM) patients compared to other types of CM, according to clinical and functional variables, by using gated-SPECT myocardial perfusion imaging (MPI).Methods: Ninety-three patients (60 ± 11 years, 28% women) referred for pre-CRT assessment were studied and divided into three groups: 1 (non-ischemic CM with LVNC, 11 patients), 2 (ischemic CM, 28 patients), and 3 (non-ischemic CM, 53 patients). All were studied by a 99mTc-MIBI gated-SPECT MPI at rest pre-CRT implantation, and 6±1 months after, including intraventricular dyssynchrony assessment by phase analysis. Quality of life was measured by the Minnesota Living with Heart Failure Questionnaire (MLHFQ).Results: No differences in sex, atherosclerotic risk factors other than smoking habit, and MLHFQ results were found among groups. LVNC CM patients were younger, with greater QRS width and lower left ventricular ejection fraction (LVEF) at baseline, but the differences were not significant. No significant differences were found at baseline regarding ventricular function, although end-diastolic volume was slightly higher in LVNC CM patients. Mean SRS was significantly higher (p<0.0001) in ischemic patients (14.9) vs. non-ischemic ones (8.7 in group 1 and 9 in group 2). At baseline, LVNC CM patients were significantly more dyssynchronous: their phase standard deviation (PSD) was higher (89.5±14.2 degrees) vs. groups 2 (65.2±23.3 degrees) and 3 (69.7±21.7 degrees), p=0.007. Although the quality of life significantly improved in all groups, non-ischemic patients (with or without LVNC) showed a higher LVEF increase and volumes reduction at 6 months post-CRT. Dyssynchrony reduced post-CRT in all groups. Nevertheless, those more dyssynchronous at baseline (LVNC CM) exhibited the most significant intraventricular synchronism improvement: PSD was reduced from 89.5±14.2 degrees at baseline to 63.7±20.5 degrees post-CRT (p=0.028). Six months post-CRT, 89% of patients were responders: 11 (100%) of those with LVNC CM, 25 (86%) of those with ischemic CM, and 47 (89%) of patients with non-ischemic CM. No patient with LVNC CM had adverse events during the follow-up.Conclusion: CRT contributes to a marked improvement in non-ischemic CM patients with non-compaction myocardium. Phase analysis in gated-SPECT MPI is a valuable tool to assess the response to CRT.
Breast Cancer Awareness Month: The Impact of Even the Most Successful Campaigns Fades
Authors: Lapostolle Frédéric , Weisslinger Lisa , Durand Charles , Adnet Frédéric 
Published: July 2020

Abstract
BackgroundFor over 35 years the ‘Breast Cancer Awareness Month’ (BCAM) has worked to increase public information about breast cancer and to raise funds for research. The aim of this study was to analyze how the interest generated by this campaign evolved over time, in the US and other countries.MethodsWe investigated the Google Trends® according to previously recommended methods. The study was based on Internet searches using the term ‘’breast cancer’’ worldwide and in the United-States. Google Trends® gives the relative search volume of every request as an index on a scale from 0 to 100, (100 corresponding to the maximum number of requests during the studied period). We compared the relative searches index using the term ‘’breast cancer’’ during October, the breast cancer awareness month, and the rest of the of the year avec a 10 years period.Results120 months were analyzed including 10 October months. Median index for worldwide searches on ‘’breast cancer’’ during the 110 months was 35 (34-39). It didn’t significantly change during the study period (R2=0,3). Median index of the 10 peaks was 83 (64-92) (p<0,001 vs 110 months). The peak index linearly decreased (R2=0,88) during the study period. It reached 100 in 2012 and 64 in 2020. In the United-States, median index for searches during the 110 months was 28 (26-32). It didn’t significantly change during the study period (R2=0,3). Median index of the 10 peaks was 83 (63-92) (p<0,001 vs 110 months). The peak index linearly decreased (R2=0,73) during the study period. It reached 100 in 2012 and 64 in 2020.ConclusionsThis internet activity study shows that the impact of the ‘Breast Cancer Awareness Month’ seems to be slowly decreasing. The number of Internet searches generated by the campaign has been reduced by almost 40% in both the United-States and worldwide.
Modeling the Environmental Suitability for Bacillus Anthracis Spores Survival in the Qinghai Lake Basin, China
Authors: Arotolu Temitope Emmanuel , Wang HaoNing , JiaNing Lv , Kun Shi , Hein Van Gils , Huang Liya , XiaoLong Wang 
Published: July 2020

Abstract
Introduction: Bacillus anthracis spores may remain viable for many years in soil. Previous studies have identified East Qinghai and neighbouring Gansu in northwest China as a potential source of anthrax infection. This study was carried out to identify conditions and areas in the Qinghai lake basin that are environmentally suitable for Bacillus anthracis spore survival. Materials and Methods: Anthrax occurrence data from 2005 – 2016 and environmental variables were spatially modeled by a maximum entropy algorithm to evaluate the contribution of the variables to the distribution of the spore. A Principal Component and Variance Inflation Analysis were adopted to limit the number of environmental variables and minimize multicollinearity. Results: The three variables that contributed most to the suitability model for B. anthracis spores are a relatively high annual mean temperature (53%), soil type (35%), and a high human population density (12%). The most significant soil types were cambisols and kastanozems. The resulting distribution map identifies the permanently inhabited rim of the Qinghai Lake as highly suitable for the survival and persistence of the spores. Conclusion: The highly suitable areas for spores could be considered as a risk zone for Anthrax infection by spores of the livestock and the human population. Our environmental suitability map and the identified variables provides the nature reserve managers and animal health authorities readily available information to devise a surveillance strategy in B. anthracis suitable regions to abate future epidemics.
Tuberculous Pericarditis with tamponade in COVID-19: A case report
Authors: WONG SHIUN WOEI , Xuan Jessica Ng Ke , Woon Chia Yew 
Published: July 2020

Abstract
IntroductionTuberculous pericarditis is a rare manifestation of tuberculosis infection. COVID-19 pandemic poses a challenge in detecting uncommon disease. Pericardial effusion with tamponade has been described with COVID-19 but the association with tuberculosis is not yet known. Case presentationA 47-year-old man was admitted with symptoms of COVID-19 infection. Rapid progression of cardiomegaly on radiograph with clinical deterioration were suggestive of pericardial tamponade. Urgent pericardiocentesis revealed hemoserous fluid, elevated adenosine deaminase and positive TB PCR. He was started on steroid, anti-tuberculous therapy and Remdesivir with marked improvement of symptoms. Repeat echocardiogram and CT Thorax showed resolution of pericardial fluid and patient was discharged well. ConclusionsThis case highlights the difficulty in detecting a concomitant rare but important disease. The development of massive pericardial tamponade acutely is not pathognomonic for COVID-19, and a careful diagnostic process involving multi-modality imaging, occurred to arrive at a diagnosis of tuberculosis.
Pruning from spheroidal to cubic canopy induced aphid outbreak by altering the plant performance in Box tree
Authors: Chen Anqun , Liu Yinzhan , Liu Xiaolin , Xuan Juan , Qiao Chunlian , Miao Renhui , Zhao Cancan 
Published: July 2020

Abstract
Backgrounds: Plant-animal interactions comprise the fundamental relationships of ecological research, and are sensitive to environmental change. However, The effects of pruning on animal-plant interactions have rarely been studied. Methods: We conducted field experiments to examine the impact of artificially-pruned shapes (e.g. cubic and spheroidal canopy) on the performance of the Box tree and the resulting aphid abundance at three sites; on a university campus, at a road green belt, and in a residential area. The differences of aphid abundance and plant morphology were determined with ANOVAs and paired-sample tests. Relationships between the investigated parameters were detected with simple regression and structural equation modelResult: Abundance was higher in plants with a cubic canopy than with a spheroidal canopy. Plants with a cubic canopy had lower leaf dry mass content and inflorescence numbers, but greater fresh twig length than the plants with a spheroidal canopy. The aphid abundance was negatively correlated with the leaf dry mass content and inflorescence numbers, and positively correlated with the fresh twig length. Conclusion: Our findings have proven that pruning shape can significantly affect the abundance of herbivores on the pruned plants. The results can provide data support for human actives can alter plant performance, and thereby to change insect preference.
Signature Based on Immune-Related LncRNA Can Predict Overall Survival of Osteosarcoma Patients
Authors: Li Longqing , Zhang Lianghao , Khader Manhas Adbul , Zhang Yan , Lu Xinchang , Zhang Yi , Liu Yongkui , Wen Jia , Liu Tao , Yuan Yaobo , Li Jiazhen 
Published: July 2020

Abstract
Background: Osteosarcoma is a malignant bone tumor common in children and adolescents. Metastatic status remains the most important guideline for classifying patients and making clinical decisions. Despite many efforts, newly diagnosed patients receive the same therapy that patients have received over the last 4 decades. With the development of high-throughput sequencing technology and the rise of immunotherapy, it is necessary to deeply explore the immune molecular mechanism of osteosarcoma.Methods: We obtained RNA-seq data and clinical information of osteosarcoma patients from TCGA database and TARGET database. With the help of co-expression analysis we identified immune-related lncRNA and then by means of univariate Cox regression analysis prognostic-related lncRNA was screened out. And also by using least absolute shrinkage and selection operator regression method a model based on immune-related lncRNA was constructed. The differences in overall survival, immune infiltration, immune checkpoint gene expression, and tumor microenvironmental immunity type between the two groups were evaluated.Results: We constructed a signature consisting of 13 lncRNA. Our results show that signatures can reliably predict the overall survival of patients with osteosarcoma and can bring net clinical benefits. Further more, the signatures can be used for further risk stratification of the metastasis patients. Patients in the low-risk group had higher immune cell infiltration and immune checkpoint gene expression. The results from gene set variation analysis show that patients in low-risk group are closely related to immune-related pathways when compared with patients in high-risk group. Finally, patients in the low-risk group are more likely to be classified as TMIT I and hence more likely to benefit from immunotherapy.Conclusion: Our signature may be a reliable marker for predicting the overall survival of patients with osteosarcoma.
Spatiotemporal evolution and diffusion pattern of the COVID-19 epidemic in Hainan Province, China
Authors: Gao Xing , Li Gang , Wang Jiaobei , Xu Tingting 
Published: July 2020

Abstract
Within one month after the first case occurred in Hainan Province, the number of confirmed cases increased to 168, and there was no increase in nearly three months. As the southernmost province and a famous tourist destination, its frequent economic exchanges and high-intensity movements may affect the spread of epidemic. Therefore, it is of great theoretical and practical significance to examine the spatiotemporal evolution and diffusion pattern of the COVID-19 epidemic in Hainan Province.
COVID-19 Confinement In Portugal: Effects On The Household Routines Of Children Under 13
Authors: Pombo André , Luz Carlos , Rodrigues Luis Paulo , Cordovil Rita 
Published: July 2020

Abstract
Objective To know how confinement affects children’s routines, more specifically their physical activity (PA) and sedentary time.MethodsAn online survey was launched to assess how Portuguese children under 13 years of age are adjusting their daily routines to confinement. Parents reported the daily time each child was engaged in different activities, which were used to calculate overall sedentary time and overall physical activity time.Results: Data from 2159 children, indicated that during confinement: i) there was a decrease in children’s physical activity time (72.3%); and an increase in screen time (71.3%) and family activities (83.9%); ii) the only sex differences were found on Playful Screen Time (boys > girls) and in Play without PA (girls > boys); iii) along age groups, there was a trend for the increase of the overall sedentary time and a complementary decrease of overall physical activity time (both F(3,2097) =97.951, p < .001).Conclusion: Overall, PA of confined children showed low levels and a clear decreasing trend along childhood. Conjoint family and societal strategies to target specific age groups should be organized in the future.
Chest X-Ray Findings and Temporal Lung Changes in Patients with COVID-19 Pneumonia
Authors: Rousan Liqa A , Elobeid Eyhab , Karrar Musaab , Khader Yousef 
Published: July 2020

Abstract
Background: Chest CT scan and chest x-rays show characteristic radiographic findings in patients with COVID-19 pneumonia. Chest x-ray can be used in diagnosis and follow up in patients with COVID-19 pneumonia. The study aims at describing the chest x-ray findings and temporal radiographic changes in COVID-19 patients.Methods: From March 15 to April 20, 2020 patients with positive reverse transcription polymerase chain reaction (RT-PCR) for COVID-19 were retrospectively studied. Patients’ demographics, clinical characteristics, and chest x-ray findings were reported. Radiographic findings were correlated with the course of the illness and patients’ symptoms.Results: A total of 88 patients (50 (56.8%) females and 38 (43.2%) males) were admitted to the hospital with confirmed COVID-19 pneumonia. Their age ranged from 3-80 years (35.2 ±18.2 years). 48/88 (45%) were symptomatic, only 13/88 (45.5%) showed abnormal chest x-ray findings. A total of 190 chest x-rays were obtained for the 88 patients with a total of 59/190 (31%) abnormal chest x-rays. The most common finding on chest x-rays was peripheral ground glass opacities (GGO) affecting the lower lobes. In the course of illness, the GGO progressed into consolidations peaking around 6-11 days (GGO 70%, consolidations 30%). The consolidations regressed into GGO towards the later phase of the illness at 12-17 days (GGO 80%, consolidations 10%). There was increase in the frequency of normal chest x-rays from 9% at days 6- 11 up to 33% after 18 days indicating a healing phase. The majority (12/13, 92.3%) of patients with abnormal chest x-rays were symptomatic (P=0.005).Conclusion: The chest x-ray findings were similar to those reported on chest CT scan in patients with COVID-19, Chest x-ray can be used in diagnosis and follow up in patients with COVID-19 pneumonia.
The Effect of Smoking on Progression From Ductal Carcinoma in Situ to Invasive Ductal Carcinoma: A Retrospective Study
Authors: Takada Koji , Kashiwagi Shinichiro , Asano Yuka , Goto Wataru , Kouhashi Rika , Yabumoto Akimichi , Morisaki Tamami , Shibutani Masatsune , Takashima Tsutomu , Fujita Hisakazu , Hirakawa Kosei , Ohira Masaichi 
Published: July 2020

Abstract
Background: If ductal carcinoma in situ (DCIS) is diagnosed by histological examination such as core needle biopsy or vacuum-assisted biopsy (VAB), invasion is often found by removing the entire tumor and performing pathological examination. According to a meta-analysis, the rate of invasion found by postoperative pathological examination is about 25%. Smoking is a risk factor for carcinogenesis in various carcinomas, including breast cancer. We examined the correlation between the risk of invasion found by postoperative pathology and smoking history in patients who were diagnosed with DCIS by preoperative biopsy.Methods: In this study, we examined 128 patients who were diagnosed with DCIS by preoperative biopsy. Before the biopsy, all patients were asked about the duration of smoking, number of cigarettes smoked per day, and whether they were currently smoking. The data were used to calculate each patient’s tobacco exposure based on pack-years. The statistical analyses included the Pearson’s chi-square test and logistic analysis. Multivariate analysis was performed on the risk factors for invasion diagnosed by postoperative pathological examination in all cases diagnosed with DCIS by preoperative biopsy.Results: Of all the patients included in this study, 107 (83.5%) never smoked, which represented the majority, while 8 patients (6.3%) smoked at diagnosis with DCIS, and 13 (10.2%) had quit smoking before diagnosis. Tobacco exposure was 10 or less pack-years for 11 patients (8.6%) and more than 10 pack-years for 10 patients (7.8%). Number of pack-years was not an independent factor (p=0.349, odds ratio [OR]=0.329), but current smoker status (p=0.006, OR=not calculable) was an independent factor with VAB (p=0.018, OR=0.327).Conclusions: This study suggests that tobacco components may have an influence on the progression from DCIS to invasive ductal carcinoma.
Comparison of a deterministic and statistical approach for the prediction of thermal indices in regulated and unregulated river reaches: case study of the Fourchue River (Québec, Canada)
Authors: Beaupré Laurie , St-Hilaire André , Daigle Anik , Bergeron Normand 
Published: July 2020

Abstract
Water temperature is an important factor modifying fish distribution patterns and community abundance in streams, and this is especially true for salmonids. Knowing that dams often modify the thermal regime of rivers, understanding these changes is of crucial importance for fish habitat management. This study aims to improve knowledge about the impact of dams on the thermal regime of rivers during the summer season and to assess the relative efficiency of two modelling tools used to predict water temperature downstream of dams. A deterministic model (Stream Network Temperature (SNTEMP)) and a statistical model based on a canonical correlation analysis were calibrated on the Fourchue River (St-Alexandre-de-Kamouraska, Québec, Canada) upstream and downstream of a reservoir. SNTEMP was used to simulate mean water temperature time series using meteorological inputs and discharge. The statistical model was used to directly estimate thermal indices (descriptive statistics of the thermal regime). The two models were compared based on their efficiency to estimate thermal indices such as mean and maximum monthly water temperatures and other parameters of importance in the understanding of the distribution and growth of ichthyofauna. Water temperature was monitored at 18 locations in the Fourchue River during the summers of 2011 and 12 locations in 2012 to describe the thermal regime and calibrate the models. The statistical model achieved better results than SNTEMP in estimating most of the thermal indices, especially the mean and maximum daily ranges with root mean square errors of 4.1 and 4.9 °C, respectively, for SNTEMP as compared to 0.5 and 1.1 °C for the leave-one-out validation and 0.6 and 1.4 °C for the split-sample mode for the statistical model. The better performance of the statistical model for metrics related to thermally stressful events for fish makes it more appealing as a management tool for water resources and fisheries managers. However, SNTEMP should be considered when the objective is to investigate the impact of climate change, reservoir operations or other anthropogenic impacts.