bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficiency of pharmacogenetic approach to anticoagulant therapy in patients with prosthetic heart valves
Authors: Gorbunova E. V. , Rozhnev V. V. , Ponasenko A. V. , Barbarash Olga Leonidovna 
Published: October 2019

Background. This study examined clinical, demographic, anthropometric, and inheritance factors that influence individual sensitivity to warfarin therapy after heart valve surgery. The clinical significance of the pharmacogenetic approach was assessed using the individual time frame and time spent in the INR therapeutic range. Aims. We determined the clinical outcome of the pharmacogenetic approach at the start of warfarin therapy in patients with prosthetic heart valves. Materials and methods. The study included 915 patients, of which 512 women and 403 men (mean age 56±10 years), living in Western Siberia. Rheumatic heart disease was the main diagnosis that caused the acquired defect. Mechanical prostheses were used in 70% of cases of cardiac surgery. Real-time polymerase chain reaction used for molecular genetic testing. Results. The frequencies of the alleles and genotypes of CYP2C9 and VKORC1 in the study population of patients with heart valves prosthetic correspond to the distribution in Caucasoid populations. The use of pharmacogenetic testing results at the beginning of warfarin therapy reduced the time required for selecting a therapeutic dose of anticoagulant by 2 times and increased the duration of stay in the INR therapeutic range by 20.2%. Conclusion. The use of the pharmacogenetic approach at the begin‑ ning of warfarin therapy contributes to the effectiveness and safety of anticoagulant therapy in this category of patients.
Knowledge, attitude and practices about hemovigilance among practitioners: a cross-sectional study
Authors: . Roshi , Tandon Vishal R. 
Published: October 2019

Abstract: Transfusion by blood and blood products forms an important part of treatment. But this is not free from transfusion reactions which may be in the form of fever, rashes, shivering, anaphylaxis or even death. Hemovigilance is a programme of reporting such events.Materials and Methods: The present study was conducted in a tertiary care hospital of Jammu, (J& K). Permission was taken from Institutional Ethics Committee, Govt. Medical College, Jammu. A pretested questionnaire was prepared and circulated among practitioners. They were given time of 15 minutes to fill that questionnaire. After 15 minutes, the filled questionnaire were collected and were analysed. The data was presented in tabulated form.Results: Total 50 practitioners were included in the study. All the practitioners had knowledge about transfusion reactions. Only 10% of the practitioners had knowledge that transfusion reactions can be prevented, 40% of the practitioners had knowledge about hemovigilance programme and had an idea that transfusion reactions can be reported. But only 10% of the practitioners knew where to report and who can report, 6% knew how to report. Only 48% of the practitioners thought that transfusion reactions should be reported, 70% of the practitioners thought that transfusion reactions can be dangerous. 40% of practitioners told that seminars/CMEs should be planned. 80% of practitioners had encountered transfusion reactions, but only 2% had documented the same. 10% of the practitioners had attended seminars, CMEs. Many reasons were quoted for not reporting transfusion reactions.Conclusion: Overall, most of the practitioners have a positive attitude towards transfusion reaction reporting but knowledge regarding the haemovigilance concept is poor and the majority of them never reported such reaction. Hence, our study demands increased awareness and continued training to strengthen the haemovigilance system.
A prospective analysis of post mastoidectomy cavity complications
Authors: Rajan Dhanya , James Susan 
Published: October 2019

<p class="abstract"><strong>Background:</strong> The main aims of surgical treatment of chronic middle ear suppuration are elimination of disease process, reconstruction of hearing mechanism and prevention of complications. The objective of this study is to find out the incidence of cavity problems after open cavity mastoidectomy. To evaluate perioperative factors involved in the causation of cavity problems.</p><p class="abstract"><strong>Methods:</strong> A prospective analytical study was conducted among 78 patients came for open mastoidectomy admitted in department of ENT. Each patient had a follow up upto three months at twice weekly intervals. In this study a borderline healing period of three months (12 weeks) was given for the complete epithelialisation of an open mastoid cavity. SPSS was used for analysis. </p><p class="abstract"><strong>Results:</strong> The incidence of postoperative cavity problems in our set up is 26.92%. Youngest patient to undergo mastoidectomy was a 4-year-old boy. The youngest patient who presented with cavity problem was of 7years. 59 (75.64%) had sclerotic mastoid and 10 (12.82%) had cellular mastoid and 9 (11.53%) had diploeic mastoid. Hence out of the 21 postoperative mastoid cavity problems, 5 cases had large postoperative cavity, 18 cases had high facial ridge, 1 case had stenosis of meatoplasty, 17 cases had exposed middle ear and eustachian tube and 17 had postoperative granulations.</p><p class="abstract"><strong>Conclusions:</strong> There should be complete exenteration of disease from the middle ear and mastoid. An adequately lowered facial ridge is an essential step to attain a dry cavity.</p>
The benefit of Curcuma longa and Boswellia serrata to improve quality of life in osteoarthritis patients: a randomized controlled trial
Authors: Pinzon Rizaldy Taslim , Sanyasi Rosa De Lima Renita , Pramudita Esdras Ardi , Periska Septian Dewi 
Published: October 2019

<p class="abstract"><strong>Background:</strong> Quality of life (QoL) can be affected by chronic pain in osteoarthritis (OA). Previous studies showed that combination of <em>Curcuma longa</em> (CL) and <em>Boswellia serrata</em> (BS) extract (CB extract) are promising for alternative treatment for pain in OA. This study aimed to measure the benefit of CB extract to improve QoL in patients with OA.</p><p class="abstract"><strong>Methods:</strong> This was a randomized controlled trial (RCT) in OA patients. Subjects were randomized to 3 different group (Group 1: CB extract (350 mg of CL and 150 mg BS) and NSAID (400 mg ibuprofen or 50 mg diclofenac sodium); group 2: CB extract; group 3: NSAID). Each medication was taken two times per day for 4 weeks. QoL measured using 5Q-5D-5L that include five dimensiones in 5Q-5D: mobility, self-care, usual activities, pain/discomfort, anxiety/depression, with 5 levels of severity.<strong></strong></p><p class="abstract"><strong>Results:</strong> There were 105 subjects at baseline. After 4 weeks of study, remained 95 subjects. The most common problem in group 1, 2, and 3 was pain (n=23, n=8, n=15 respectively). The improvement of level of severity in group 1 after 4 weeks of treatment was significant in mobility problems (p=0.002), pain/discomfort (p&lt;0.001), and anxiety/depression (p=0.008). A significant improvement was only seen in usual activity problems (p=0.013) in group 2. The decrease of level of severity in usual activity problems (p=0.034), pain/discomfort (p=0.005), and anxiety/depression (p=0.018) in group 3 were also statistically significant.</p><p class="abstract"><strong>Conclusions:</strong> CB extract was beneficial to improve QoL in OA patients with a less side effect compared to NSAID.</p>
Characteristics of the Sternal Fractures and Associated Injuries: A Three-year Clinical Experience Sternal Fractures and Associated Injuries
Authors: KADİOGLU Emine , YALCİNKAYA Serhat 
Published: October 2019

Background Although they constitute a small portion of thoracic trauma, sternal fractures require attention as they may be indicators of major cardiac injuries. The aim of this study is to review the diagnosis, treatment, and outcome of such patients administered to our emergency department. Material and Methods The archive files of the patients administered to the emergency department due to thoracic trauma and diagnosed to have sternal fractures between January 2015 and December 2017 were reviewed for age, gender, type of trauma, type of injury, associated injuries, and clinical outcome. Results There were 27 male, and 6 female patients. The mean age was 48.9 ± 16.50 years (20-79). The most frequent cause was vehicle accident. The sternal fracture was isolated in 13, and associated with other injuries in 20 patients. Eight of the isolated fracture patients and all of the latter were hospitalized. Six of the patients underwent tube thoracostomy, one bilateral. When the length of hospital stay is compared between the two groups, sternal fracture with associated injury patients stayed in the hospital for significantly longer periods. Conclusion Although isolated sternal fracture is benign in nature and may be treated with basic measures, when associated with other injuries, it becomes more complicated to treat, and the length of hospital stay increases significantly.
La Banca privada, la legislación bancaria y la centralización bancaria entre 1870 y 1923 en Colombia.
Authors: Lesmes Pedro José 
Published: October 2019

El objetivo de este artículo es mostrar el proceso legal de la banca privada, el cual se originó en Colombia durante el periodo del Radicalismo Liberal (1863-1886). El ascenso de la Regeneración en 1886, su avance sobre el país el Centralismo presidencialista, de corte católico y autoritario, afectaría los intereses de los banqueros, comerciantes y productores que utilizaban los beneficios de la banca libre. La metodología empleada es de carácter cualitativa y busca realizar el análisis de las regulaciones, problemas y dificultades que se presentaron en Colombia entre 1870 y 1923. Se destacó que ante las dificultades para organizar el sistema bancario en Colombia fue necesario establecer con mayor severidad controles a los Bancos Privados, por ejemplo, la Misión Kemmerer en 1922, con la cual se planteó la necesidad de centralizar el sistema financiero del país, dando de esta manera origen al Banco de la República, con funciones de Banco Central y regulando los bancos privados por medio de la Superintendencia Bancaria.
The Lumbosacral Takeoff Angle Can Be Used to Predict the Postoperative Lumbar Cobb Angle Following Selective Thoracic Fusion in Patients with Adolescent Idiopathic Scoliosis
Authors: Bachmann Keith R. , Lu Edwin , Novicoff Wendy M. , Newton Peter O. , Abel Mark F. ,   on behalf of the Harms Study Group
Published: October 2019

Background:
Selective fusion of double curves in patients with scoliosis is considered to spare fusion levels. In 2011, we studied the lumbosacral takeoff angle, defined as the angle between the center-sacral vertical line and a line through the centra of S1, L5, and L4. The lumbosacral takeoff angle was shown to moderately correlate with the lumbar Cobb angle, and a predictive equation was developed to predict the lumbar Cobb angle after selective fusions. The purposes of the present study were to validate that equation in a separate cohort and to assess differences in outcomes following selective and nonselective fusion.

Methods:
Patients with Lenke 1B, 1C, 3B, or 3C curve patterns undergoing fusion (both selective and nonselective) with pedicle screw constructs and a minimum of 2 years of follow-up were included. Selective fusion was defined as a lowest level of fixation cephalad to or at the apex of the lumbar curve. To validate the previously derived equation, we used this data set and analysis of variance to check for differences between the actual and calculated postoperative lumbar Cobb angles. Pearson correlation, multiple linear regression, and t tests were used to explore relationships and differences between the selective and nonselective fusion groups.

Results:
The mean calculated postoperative lumbar Cobb angle (and standard deviation) (22.35° ± 3.82°) was not significantly different from the actual postoperative lumbar Cobb angle (21.08° ± 7.75°), with an average model error of −1.268° (95% confidence interval, −2.649° to 0.112°). The preoperative lumbar Cobb angle was larger in patients with deformities that were chosen for nonselective fusion (50.2° versus 38.9°; p < 0.001). Performing selective fusion resulted in a 3.5° correction of the lumbosacral takeoff angle (p < 0.001), whereas nonselective fusion resulted in a 9.3° correction (p < 0.001).

Conclusions:
The lumbosacral takeoff angle can be used to predict the residual lumbar Cobb angle and may be used by surgeons to aid in the decision between selective and nonselective fusion. The change in the lumbosacral takeoff angle following selective fusion is small. Improvement in the lumbosacral takeoff angle and coronal balance is greater in association with nonselective fusion.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Intraoperative Sensing Technology to Achieve Balance in Primary Total Knee Arthroplasty
Authors: Ghirardelli Stefano , Bala Abiram , Peretti Giuseppe , Antonini Guido , Indelli Pier F. 
Published: October 2019

» Instability following total knee arthroplasty has been reported as a major cause for early or delayed total knee arthroplasty revision.» Balancing the knee remains an inexact art with no standardized protocol to optimize soft-tissue tension.» The sensing technology reviewed in this article allows surgeons to intraoperatively analyze several parameters, including tibiofemoral rotational alignment, quantitative pressure at peak contact points in the medial and lateral compartments during both total knee arthroplasty trialing and final implant positioning, evaluation of the kinematics of the prosthetic knee, and, finally, correcting soft-tissue imbalance in real time.» This technology has the potential for improved outcomes, reduction in constrained implant utilization, increased patient satisfaction, and lower revision rates.
Baculogypsina Sulaimanensis N. Sp. (calcarinidae) from the Priabonian of Sulaiman Range, Pakistan: a Possible Ancestor For the Recent Baculogypsina Sphaerulata
Authors: Özcan Ercan , Hohenegger Johann , Yücel Ali Osman , Kayğılı Sibel , Ali Nowrad , Hanif Muhammad 
Published: October 2019

AbstractPriabonian ‘Pellatispira-beds’ of the Drazinda Formation in Sulaiman Range, Pakistan, contain rare calcarinids displaying similar morphological traits known from Pliocene–Recent Baculogypsina (Sacco, 1893). These specimens possess a biconvex-lenticular test with 5–8 spines characterized by anastomosing canals. The small, poorly observed protoconch is followed by a series of low trochospiral chambers, which are followed by a cyclical arrangement of chambers, producing lateral chamberlets on both test sides. The lateral sides of the test are pierced by piles of almost uniform size. Spines arise from the initial spiral part and enlarge with growth. The shape, number, and size of lateral chambers are characteristic of the genus Baculogypsina, which extends the range of this genus into the late Eocene. We have assigned these previously undescribed specimens as Baculogypsina sulaimanensis n. sp. Occurring sporadically, the new taxon is associated with Heterostegina indusensis, Silvestriella tetraedra, Pellatispira madaraszi, Assilina ex. gr. alpina, and reticulate Nummulites.
Contribuciones en la modelación de energía renovable en sistemas de potencia
Authors: Rivera-Rodríguez Sergio Raúl , Dorado-Rojas Sergio Andrés 
Published: October 2019

En este artículo se realiza un análisis de la literatura científica producida en materia de modelación y simulación de sistemas de potencia con penetración de energía renovable. Por medio de una revisión documental de los trabajos publicados por el investigador en cuestión, se sintetizaron los aspectos más innovadores de tales estudios y las herramientas utilizadas, con el fin de aportar una valiosa contribución a la búsqueda de soluciones óptimas de los problemas operacionales y de planeación que se presentan en los sistemas eléctricos gracias a la creciente penetración de fuentes de energía renovable.
Dicha revisión se abordó a través de la agrupación del material científico de acuerdo con las siguientes subtemáticas: energía renovable en Latinoamérica y Colombia; modelación de incertidumbre de sistemas solares, eólicos, pequeñas centrales hidroeléctricas y vehículos eléctricos y optimización heurística aplicada a sistemas de potencia con penetración de energía renovable.
A partir de ello se exponen tanto la aplicabilidad como los beneficios del desarrollo de formulaciones matemáticas, por lo general complejas, que permiten garantizar robustez, estabilidad, eficiencia, flexibilidad y rentabilidad de dichos sistemas.
Como resultado de la aplicación de la modelación de incertidumbre propuesta en redes similares a las identificadas, se obtuvo la compilación simplificada de un bagaje invaluable de conocimientos particularmente útiles para evaluar la integración de las tecnologías de las energías renovables en cualquier sector económico.
Experimental implantoplasty outcomes correlate with fibroblast growth in vitro
Authors: Maal Mehrnaz Beheshti , Ellingsen Stig Aanerød , Reseland Janne Elin , Verket Anders 
Published: October 2019

Abstract
Background

Implantoplasty is an option in peri-implantitis treatment, but little is known about the effect on the soft tissue. The aim of the study was to characterize surface roughness following experimental implantoplasty and to examine its effect on human fibroblast growth and the secretion of selected proteins.Methods

Titanium grade IV coins were mechanically treated with six different rotating bur sequences; diamond burs or carbide burs alone, or followed by either Arkansas stone bur or silicone burs. Machined and rough-surface sandblasted, acid-etched (SLA) coins were used as control. The surface topography was characterized by scanning electron microscope and profilometer. Human gingival fibroblasts from two donors were cultured on the coins to quantify the effect on cell morphology, growth and protein secretion by confocal microscopy and multiplex immunoassay.Results

All surface roughness parameters were lower for the surfaces treated with experimental implantoplasty than for the SLA surface, and the sequence of carbide burs followed by silicone burs rendered the least rough surface of the test groups. The implantoplasty procedures changed the elemental composition of the titanium surface. High surface roughness showed a weak to moderate negative correlation to fibroblast growth, but induced a higher secretion of VEGF, IL-6 and MCP-3 to the cell medium compared to the least rough surfaces of the test groups. At day 30 fibronectin levels were higher in the SLA group.Conclusions

The surface roughness following implantoplasty demonstrated a weak to moderate negative correlation with the growth of fibroblasts. The addition of Arkansas stone and silicon burs to the experimental implantoplasty bur protocol rendered an initial increase in fibroblast growth. Implantoplasty altered the elemental composition of the titanium surface, and had an effect on the fibroblast cytokine secretion and fibronectin levels.
Staffing rural hospitals through Umthombo Youth Development Foundation (UYDF) in South Africa: Challenges and Opportunities
Authors: Zihindula Ganzamungu , MacGregor Richard Gavin , Ross Andrew John 
Published: October 2019

Abstract
Despite the governments ‘healthcare for all’ focus since the country’s first democratic election in 1994, many rural district hospitals in South Africa have struggled to find and retain adequate staffing levels in order to be able to deliver on the District hospital package of services. Many of these hospitals have relied on non-profit organisations and other privately owned institutions to assist them in improving their staffing levels and service delivery. Umthombo Youth Development Foundation (UYDF), a NPO’s started in 1999 at one rural hospital in the Province KwaZulu-Natal, provides funding to youth from rural areas to study a health science degrees with the understanding that they will return to serve at their rural-based hospitals. This review describes the role that UYDF has played in assisting rural-based hospitals with recruiting and retaining staff, the relationship between UYDF and hospitals, the ‘UYDF’ model, as well as the challenges and opportunities presented through the partnership between UYDF and rural district hospitals. It aims to inform and contribute to health policy initiatives that can help rural-based hospitals to recruit, attract and retain staff. Using a case study research design, existing data was used to present a detailed descriptive analysis of the UYDF health education and employment model. The results from this research paper suggest that the model provides a solution which can address the problem of hospital staffing, and that if challenges are managed, other rural-based hospitals in the country could benefit from the model.
Feeding practices of children aged 0 to 24 months with clefts attending a specialized hospital in Uganda
Authors: Nabatanzi Maureen , Seruwagi Gloria Kimuli , Tushemerirwe Florence Basiimwa , Lubogo David 
Published: October 2019

Abstract
Background: Appropriate feeding practices are vital for child nutrition. Despite a low incidence of 0.73 in 1000, Ugandan children with oral clefts face feeding difficulties that affect their feeding practices, nutrition status and health.Objective: To determine the feeding practices, techniques and maternal feeding knowledge among children with oral clefts attending Comprehensive Rehabilitative Services of Uganda (CoRSU) HospitalMethods: This survey was part of a cross-sectional study on feeding practices, mothers’ experiences and support. We consecutively sampled 32 mothers of children with oral clefts aged 0 to 24 months attending CoRSU hospital between April and May, 2018. A structured questionnaire collected data on feeding practices, techniques and maternal feeding knowledge. Descriptive statistics were analyzed using SPSS software.Results: Most children (56%) had cleft lip and palate. Early initiation of breastfeeding was 44% and exclusive breastfeeding was 35%. None continued breastfeeding beyond 12 months. Timely introduction of complementary foods was 75%. 58% met the minimum dietary diversity score, 83% met the minimum meal frequency and 33% received a minimum acceptable diet. 75% of the mothers used bottles, cups and spoons in feeding their children. Majority preferred the specialized soft bottle (50%). 28% of the mothers were knowledgeable on the World Health Organization recommended feeding practices. Conclusions: This cleft group had suboptimal feeding practices since none of the children breastfed beyond 12 months and only one third received an acceptable diet. Varied feeding techniques were employed to improve feeding; majority preferred the specialized soft bottle. Most mothers had inadequate knowledge on feeding. There is need to improve the feeding guidance given to mothers of children with oral clefts. Our findings can guide the design of appropriate feeding interventions for this group.