bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovative business development: identifying and supporting future radical innovators
Authors: Schmidt Sina , von der Oelsnitz Dietrich 
Published: May 2020

AbstractAs the corporate environment becomes more volatile, uncertain, complex and ambiguous, companies are challenged to simultaneously adapt to multiple scenarios, develop radical innovations and destroy past successes. This flexible, i.e. agile and user-oriented, exploration must be ensured by exploiting already established efficiencies ("ambidextry"). However, most German SMEs do not engage in both radical and evolutionary innovations. Therefore, they tend to be disrupted. By investigating existing models regarding vuca-resilience and the development of radical innovations it was found that no practical guideline exists that provides established companies with VUCA-foresight in order to collaborate with radical innovators and thus achieve ambidextry. In order to close that gap, experts of five German companies were interviewed regarding their company’s innovation behaviour. Based on the interviews as well as scientific approaches regarding VUCA-resilience and the development of radical innovations a ten-step guideline has been derived. The success of the model has been proofed by three German SMEs that initially pushed little or no radical innovation and subsequently even founded their own company builders. Since this paper only shows the ideal way for established companies to achieve ambidextry with the help of radical innovators, further research is needed to provide solutions for non-ideal cases. Additional validation can be achieved in which the model is not only validated by German SMEs, but also by companies of other sizes and countries.
Doble aneuploidia 48, Xxy, +21 en células de líquido amniótico a las 16 semanas de gestación
Authors: Prieto Andrea Carolina , Torres Carolina , Jimeneza Daniel , Ramireza Lev , Celis Luis Gustavo , Fernández Isabel 
Published: May 2020

El síndrome de Down y el síndrome de Klinefelter son los trastornos más comunes de los cromosomas autosómicos y sexuales respectivamente. Sin embargo, la existencia de las dos anormalidades en un mismo individuo es una anomalía poco frecuente. Este artículo tiene como objetivo documentar un caso de doble aneuploidía: síndrome de Down-Klinefelter; así mismo, realizar una revisión sistemática de la alteración, factores relacionados y las manifestaciones frecuentemente presentadas. Aquí se presenta el caso de unapaciente de 39 años con embarazo de 16 semanas de gestación con alto riesgo por edad materna avanzada y con antecedente de síndrome de Down por línea paterna; a quien se le indica amniocentesis para realización de cariotipo y se obtiene un resultado de 48, XXY, + 21 [20]. Agregado a esto, se realiza asesoramiento genético a los padres, no obstante, se pierde la gestación espontáneamente en la semana 20.
Según la literatura, la doble aneuploidía Down-Klinefelter está estrechamente relacionada a la edad materna como principal factor de riesgo. Además, se menciona un solapamiento de las condiciones; normalmente, son predominantes las características fenotípicas del síndrome de Down. Finalmente, será fundamental realizar un cariotipo en cualquier paciente que presente síndrome de Down, para verificar que no exista asociación a otros síndromes y un acompañamiento durante la vida será de gran importancia
Hepatocellular Carcinoma in a Patient With Hepatic Steatosis
Authors: Romano John , Forster Erin 
Published: May 2020

ABSTRACT
Hepatocellular carcinoma (HCC) has historically developed in the setting of known risk factors—chronic liver disease from viral hepatitis and cirrhosis. In the absence of a risk factor, the development of HCC was rare. However, the increasing prevalence of nonalcoholic liver disease and nonalcoholic steatohepatitis, the paradigm is shifting. Currently, no HCC screening guidelines exist for these patients. We report a 30-year-old man with a medical history of treated nonseminomatous germ cell testicular cancer who presented with asymptomatic transaminitis. Subsequent workup was notable for a 1.6-cm liver lesion. The patient underwent a left lobe wedge resection with pathology demonstrating a well-differentiated HCC in a background of hepatic steatosis.
Towards Tawang Station Area as Smart Urban Railway Space
Authors: Huwaida Nurma Mediasri , Nugroho Agung , Joenso Reivandy Christal 
Published: May 2020

The purpose of this research is to analyze the possibility of implementing Smart Urban Railway Space concept in the development of Semarang Tawang Station area which is one of the entrance gates of Semarang tourists and has a high historical value. The area of Tawang station becomes an integral part of Semarang Old Town because of its adjacent location. This attachment is one potential that can be considered to grow the activity of the area into a tourism area and a business center. Increasing number of visitors can cause overcrowding. The crowded situation of visitors caused the lack of circulation so that the need for redesigning Tawang station area. A station area (public transportation) must be able to adapt to the environment and function needs for the visitor. Smart city design is about rethinking infrastructure, buildings and facilities as well as other infrastructure integrated to form smart cities and smart urban space. Smart Urban railway space is a concept that integrates an architectural building with the surrounding open space. It is hoped that this concept can parse overcrowding and make the area of Tawang station a tourism area. Methods used are qualitative methods with a rationalistic approach. The result of this research is a recommendation of the Smart Urban Railway Space concept at Tawang station area which is expected to parse the overcrowding problem that occurred.
Pengaruh ekstrak buah naga daging merah (Hylocereus polyrhizus) terhadap berat badan, indeks fagositosis makrofag dan produksi nitrit oksida makrofag (Studi pada mencit BALB/c yang diinfeksi Salmonella typhimurium)
Authors: Kusdalinah Kusdalinah , Johan Andrew , Wijayahadi Noor 
Published: May 2020

Background: Salmonella typhimurium has ability to avoid the phagosome and escape from the trap-free in cytoplasm.Macrophage was activated to phagocyte microbe and produced microbicidal agent nitric oxide (NO).Polyphenolic compounds are proved as an immunomodulatory agent.Hylocereus polyrhizus contains high level of polyphenols and thus increases appetite.Objective: Proving the effects various doses (6 mg, 12 mg, and 24 mg/20 g mice’s weight) of Hylocereus polyrhizus extract to increase weight, increase macrophage phagocytosis and NO production of macrophage.Methods:True experiment research for fourteen day on males BALB/c mice, post-test only controlled group design.The treatment groups were a dose of 6 mg/day (X1), 12 mg/day (X2), and 24 mg/day (X3), whereas the control group (K) was not given the extract of Hylocereus polyrhizus.All treatment and control groups were infected by Salmonella typhimurium intraperitoneally 105 CFU in tenth day.Results: Weight in the treatment group was higher than the control group (p=0.037). Index of macrophage phagocytosis was higher in the treatment group compared to the control group but it was not significant (p=0.154). Macrophage NO production was higher in the treatment group compared to the control group but was not significant (p=0.332).Conclusion: Weight increased significantly.Increasing of macrophage phagocytosis index and macrophage NO production were not significant.
Pengaruh pemberian klorofilin berbagai dosis terhadap indeks fagositosis makrofag dan kadar nitric oxide mencit BALB/c yang diinfeksi dengan Salmonella typhimurium
Authors: Arum Puspito , Suromo Lisyani B , Puruhita Niken 
Published: May 2020

Background: Immune responses to eliminate Salmonella infection are by activating macrophage and by producing NO. Chlorophyllin is a chlorophyll derivate that has immunomodulator properties. Objective: The aim of this study was to prove effect of chlorophyllin in macrophage phagocytosis index and NO level. Methods: A post test only controlled group design was conducted in 5 groups Balb/c mice (negative control, positive control, dosage 100 µg/200 g BW, dosage 200 µg/200 g BW and dosage 380 µg/200 g BW). Macrophage phagocytosis index was measured by counting cells that phagocyte latexs particles. NO level was measured by Griess method. Macrophage phagocytosis index difference was analyzed by one way anova and NO level deference was analyzed by Kruskall-Wallis test (α 0,05).Results: Means of macrophage phagocytosis index were 0,7(±0,80), 1,8(±0,80), 2(±0,22), 2,5(±0,43) and 3,2(±0,68) respectively in negative control, positive control, chlorophyllin dosage 100 µg/g BW/day, 200 µg/g BW/day and 380 µg/g BW/day. There was a significant difference of macrophage phagocytosis index between group (p 0,000). Mean of NO level were 0,4 µM(±0,10), 0,6 µM(±0,60), 0,8 µM(±0,64), 0,6 µM(±0,67) and 0,4 µM(±0,26) respectively in negative control, positive control, chlorophyllin dosage 100 µg/g BW/day, 200 µg/g BW/day and 380 µg/g BW/day. There was no difference of NO level between group (p 0,813).Conclusion: There was a significant difference of macrophage phagocytosis index between chlorophyllin administered group and control. The higher chlorophyllin dosage, the higher macrophage phagocytosis index. Therewas no difference of NO level between chlorophyllin administered group and control.
Differential Stability of miR-9-5p and miR-9-3p in the Brain Is Determined by Their UniqueCis- andTrans-Acting Elements
Authors: Kim C.K. , Asimes A. , Zhang M. , Son B.T. , Kirk J.A. , Pak T.R. 
Published: May 2020

AbstractmicroRNAs (miRs) are fundamental regulators of protein coding genes. In the CNS, miR-9 is highly enriched and critical for neuronal development and function. Mature miRs are derived from a duplex precursor, and the -5p strand (“guide”) is preferentially incorporated into an RNA-induced silencing complex (RISC) to exert its regulatory functions, while the complementary -3p strand (“passenger”) is thought to be rapidly degraded. By contrast, both strands of the miR-9 duplex have unique functions critical for neuronal physiology, yet their respective degradation rates and mechanisms governing degradation are not well understood. Therefore, we determined the degradation kinetics of miR-9-5p and miR-9-3p and investigated thecisandtranselements that affected their stability in the brain. Using a combination of homogeneous neuronal/astrocyte cell models and heterogeneous brain tissue lysate, we demonstrate the novel finding that miR-9-3p was more stable than the miR-9-5p guide strand in all models tested. Moreover, the degradation kinetics of both miR-9-5p and miR-9-3p were brain-region specific, suggesting that each brain region was differentially enriched for specific degradation factors. We also determined that the 3′ nucleotides harbor importantciselements required to not only maintain stability, but also to recruit potential protein degradation factors. We used mass spectrometry to assess the miR-9 interacting proteins and found that the -5p and -3p strands were associated with functionally distinct proteins. Overall, these studies revealed unique miR-9-5p and miR-9-3p degradation kinetics in the brain and proposed critical nucleotide sequences and protein partners that could contribute to this differential stability.
Coinfection and Other Clinical Characteristics of COVID-19 in Children
Authors: Wu Qin , Xing Yuhan , Shi Lei , Li Wenjie , Gao Yang , Pan Silin , Wang Ying , Wang Wendi , Xing Quansheng 
Published: May 2020

BACKGROUND AND OBJECTIVES:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly identified pathogen that mainly spreads by droplets. Most published studies have been focused on adult patients with coronavirus disease 2019 (COVID-19), but data concerning pediatric patients are limited. In this study, we aimed to determine epidemiological characteristics and clinical features of pediatric patients with COVID-19.

METHODS:
We reviewed and analyzed data on pediatric patients with laboratory-confirmed COVID-19, including basic information, epidemiological history, clinical manifestations, laboratory and radiologic findings, treatment, outcome, and follow-up results.

RESULTS:
A total of 74 pediatric patients with COVID-19 were included in this study. Of the 68 case patients whose epidemiological data were complete, 65 (65 of 68; 95.59%) were household contacts of adults. Cough (32.43%) and fever (27.03%) were the predominant symptoms of 44 (59.46%) symptomatic patients at onset of the illness. Abnormalities in leukocyte count were found in 23 (31.08%) children, and 10 (13.51%) children presented with abnormal lymphocyte count. Of the 34 (45.95%) patients who had nucleic acid testing results for common respiratory pathogens, 19 (51.35%) showed coinfection with other pathogens other than SARS-CoV-2. Ten (13.51%) children had real-time reverse transcription polymerase chain reaction analysis for fecal specimens, and 8 of them showed prolonged existence of SARS-CoV-2 RNA.

CONCLUSIONS:
Pediatric patients with COVID-19 presented with distinct epidemiological, clinical, and radiologic characteristics from adult patients. Nearly one-half of the infected children had coinfection with other common respiratory pathogens. It is not uncommon for pediatric patients to have prolonged fecal shedding of SARS-CoV-2 RNA during the convalescent phase.
Representation-based models in the current landscape of phonological theory
Authors: Bérces Katalin Balogné , Honeybone Patrick 
Published: May 2020

AbstractWe place the healthy diversity of current (i.e., early 21st-century) phonological theory under scrutiny, and identify the four fundamental approaches that make it up: Rule-Based Phonology, Representation-Based Phonology, Constraint-Based Phonology, and Usage-Based Phonology. We then focus on the key aspects of and recent developments in Representation-Based Phonology: we separate out hybrid models and purely representational ones, we identify Government Phonology (GP) as the most popular form of the latter (and show that it is even present in what we call ‘GP-friendly’ analyses), and finally, we discuss and illustrate recent innovations in both subsegmental and prosodic structure in the two strands that we identify as ‘hyperhierarchical’ (or ‘vertical’) and ‘flat’ (or ‘horizontal’).
Tense? (Re)lax!
Authors: Pöchtrager Markus A. 
Published: May 2020

AbstractThis article looks at what is referred to as the tense/lax contrast in English and proposes that members of the two sets of vowel have the same basic structure but differ in how part of that structure is made use of by its neighbours. The proposal forms part of a general theory of the representation of vowel height within the framework of Government Phonology 2.0.
The inflection of Tigre weak-final and strong verbs
Authors: Faust Noam 
Published: May 2020

AbstractThis paper provides a complete, exclusively phonological account of the alternations in the paradigms of the two largest verbal types in the Ethio-Semitic language Tigre. It is proposed that “weakfinal” verbs are constructed using the same templates and vocalizations as “strong” verbs. All of the differences between the two inflectional paradigms follow from weak-final verbs involving a vowel /e/ where strong verbs position a consonant. The analysis, conducted with the tools of Strict CV Phonology and Element Theory, is the first of its kind for Tigre.
RESIF RAP and RLBP Dataset of Earthquake Ground Motion in Mainland France
Authors: Traversa Paola , Maufroy Emeline , Hollender Fabrice , Perron Vincent , Bremaud Vincent , Shible Hussein , Drouet Stéphane , Guéguen Philippe , Langlais Mickael , Wolyniec David , Péquegnat Cathérine , Douste-Bacque Isabelle 
Published: May 2020

AbstractThis work presents the implementation of a high standards dataset of earthquake ground motions recorded in Metropolitan France between 1996 and 2016. This dataset is intended to serve the scopes of a large seismological community; however, its primary aims are engineering seismology and earthquake engineering applications. The dataset includes records from broadband and accelerometric sensors provided by permanent and temporary seismic networks operated by French research institutions and partners grouped within the Réseau Sismologique et géodésique Français (RESIF) consortium (see Data and Resources). All the waveforms are first homogenized to acceleration units and underwent a full quality control process including: (1) visual verification and manual phase picking, (2) processing scheme, and (3) consistency check by residual analysis. These make the dataset fully compliant with international standards. Finally, the RESIF dataset includes more than 6500 quality-checked records from 468 earthquakes recorded at 379 stations. Over the 379 stations included in the dataset, 177 are permanent stations (RA and FR networks) and 202 are temporary stations (YP and X7 networks). The dataset is complete down to magnitude ML 3.5 over the whole French territory and less (about ML 2.5) in the eastern part. Magnitudes range from ML 2.4 to 5.6 and from Mw 2.0 to 5.2, whereas distances range from less than 1 to 600 km. The disseminated dataset is constituted of (1) a versioned flatfile containing the metadata and main intensity measures computed on each processed record, (2) time histories, and (3) response spectra for several damping values and Fourier spectra.
Prevalence of Fetomaternal Indications of Therapeutic Abortions in Yazd Province
Authors: Khajehnoori Sahel , Tabatabaee Razieh Sadat , Lookzadeh Mohammad Hossein , Mojibian Mahdieh , Mirjalili Mehdi , Amjadi Nooshin , Ghasemifar Sina , Mazaheri Mahta 
Published: May 2020

Background: Therapeutic abortion is defined as intentional termination of pregnancy in order to save the mother’s life and health or when the fetus has an abnormality incompatible with normal life.The aim of this study was to evaluate causes of issuance of therapeutic abortion in women referred to the Yazd province Legal Medicine Organization to terminate the pregnancy.

Methods: In this cross sectional study, all the applications for therapeutic abortions from March 2014 to March 2016 approved by the legal medicine organization of Yazd province were included and recorded. The data was analyzed by SPSS software.

Results: From 333 permissions for abortion during three years ,299 cases (89.8%) were issued for the reason of fetal indications and 34 cases (10.2%) for maternalindications. The most prevalent fetal abnormalities indicated for abortion were central nervous system disorders (especially Anencephaly and Spina Bifida); Hydrops Fetalis and Down syndrome, respectively and the most frequent maternal disorders were cardiovascular diseases.

Conclusion: The current study shows that therapeutic abortions due to fetal abnormalities are increasing. It seems that educating health professionals and people and increasing their awareness about preventing fetal abnormalities and also contraception in women with maternal diseases indicated for abortion could be an effective way to reduce the rate of abortion.
Association between Transforming Growth Factor Alpha TaqI Polymorphism and Susceptibility to the Nonsyndromic Cleft Lip and/or Palate in an Iranian Population: A Case Control Study
Authors: Amooee Abdolhamid , Niktabar Seyed Mohammadreza , Akbarian-Bafghi Mohammad Javad , Morovati-Sharifabad Majid , Lookzadeh Mohamad Hosein , Mirjalili Seyed Reza , Khajehnoori Sahel , Neamatzadeh Hossein 
Published: May 2020

Background: The TGF-α TaqI C >T polymorphism is a well-characterized variant for nonsyndromic cleft lip and/or palate (NS CL/P), but it has shown inconsistent results of association with nonsyndromic CL/P across a number of studies. Thus, we have performed this case-control study to clarify the association between the TGF-α TaqI C >T polymorphism and NS CL/P risk.

Methods: One-hundred ten cases with NSCL/P and 110 controls were recruited to the current study. We have genotyped the TGF-α TaqI C >T polymorphism using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The odds ratio (OR) and 95% confidence interval (CI) were applied for strength of association TGF-α TaqI C >T polymorphism with NSCL/P.

Results: The TGF-α TaqI C >T polymorphism CC, CT and TT genotypes frequencies in the NSCL/P cases were 30.9%, 57.3% and 11.8%, respectively while the corresponding frequencies in the controls were 37.3%, 52.7% and 10.0%, respectively. The frequency of C and T alleles in the case were 59.5% and 40.5%, respectively while the corresponding allelic frequencies in the controls were 63.6% and 36.4%. There was no significant difference in the genotype and allele frequency for TGF-α TaqI C >T polymorphism between cases and controls. The minor allele frequency (MAF) of TGF-α TaqI C >T polymorphism among healthy controls was 0.36.

Conclusion: Our study indicates that the TGF-α TaqI C>T polymorphism was not significantly associated with increased risk of NS CL/P in the Iranian population. However, our results still need to be confirmed by further large and well-designed case-control studies.
How social network applications enhancing team project collaborations at home
Authors: Vanichvatana Sonthya 
Published: May 2020

Team project collaboration is an important teaching and learning activity. Informal learning spaces are required to support such outside classrooms learning activity. There are increasing numbers of students who use virtual space platforms and social network applications (SNA) to support team project works at home. The objectives of this study were to understand how students used SNA to support team project works at home, how they learn about SNA, studentsâ€™ views of pro and con of SNA, and how much students need any supports from higher education institutions on this matter. This research used business students of a Bangkok private university as a case study. The results showed that though numerous advantages of SNA, students still valued face-to-face meetings in many phases of a team project. Students with higher cumulative grade point averages reflected higher proportions of needs for universities to teach them how to use SNA for team project collaboration at home than the lower cumulative grade point average students.
Keywords: Higher education institutions; Home; Informal learning spaces; Social network applications; Virtual spaces
Stromal-Immune Cell Crosstalk Maintains Type 2 Immune Cell Populations within Visceral Adipose Tissue
Authors: Moyat Mati , Coakley Gillian , Harris Nicola 
Published: May 2020

Abstract
Type 2 immune cells are key to the maintenance of healthy adipose tissue, however the cues responsible for the establishment and maintenance of adipose type two immune cells remain unclear. Rana et al. report a specialized stromal cell produces interleukin-33 (IL-33) that activates group 2 innate lymphoid cells (ILC2s). Activated ILC2s in turn produce type two cytokines that elicit further IL-33 production by the stroma in a positive feedback loop that maintains the type 2 immune cell network within visceral adipose tissue (VAT).
PENGARUH STRATEGI PEMBELAJARAN DAN GAYA BELAJAR TERHADAP HASIL BELAJAR PENDIDIKAN KEWARGANEGARAAN
Authors: Solihatin Etin 
Published: May 2020

ABSTRACT
With regards to findings of the study, it can be concluded that in general, (1) the use of Cooperative Learning strategy has given higher achievement in learning Civics than that of Expository one; (2) the use of Cooperative Learning strategy with learners of field independent learning style has effect in the form of higher achievement in learning Civics than that of Expository one; (3) the use of Cooperative Learning strategy with learners of field dependent learning style has effect in the form of lower achievement in learning Civics than that of Expository one; and (4) there is interaction between the use of learning strategy and learner's learning style on learner's achievement in learning Civics.