bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 28-Day Carbohydrate-Restricted Diet Improves Markers of Cardiovascular Disease in Professional Firefighters
Authors: Waldman Hunter S. , Smith JohnEric W. , Lamberth John , Fountain Brent J. , Bloomer Richard J. , Butawan Matthew B. , McAllister Matthew J. 
Published: August 2020

Abstract
Waldman, HS, Smith, JW, Lamberth, J, Fountain, BJ, Bloomer, RJ, Butawan, MB, and McAllister, MJ. A 28-day carbohydrate-restricted diet improves markers of cardiovascular disease in professional firefighters. J Strength Cond Res 34(10): 2785–2792, 2020—This study compared the effects of a 4-week, nonketogenic, carbohydrate-restricted (<25% of calories) diet (CRD) on markers of inflammation and oxidative stress in professional firefighters (FF). Subjects (n = 15) reported to the laboratory for 2 sessions (i.e., baseline and post-CRD) where blood was drawn from an antecubital vein after a 10-hour overnight fast. Dependent variables measured at baseline and post-CRD included adiponectin, insulin, human growth hormone, cortisol, C-reactive protein, albumin, lipids, glucose, amylase, creatine kinase, malondialdehyde (MDA), advance oxidation protein products (AOPP), total nitrate + nitrite, and soluble intracellular adhesion molecule-1. Compared with baseline, the CRD resulted in dramatic improvements to subjects' cardiometabolic profiles, including decreases in AOPP (51.3 ± 27.3 vs. 32.9 ± 7.9 ng·ml−1), MDA (1.6 ± 0.6 vs. 1.1 ± 0.5 µmol·L−1), and triglycerides (84.4 ± 34.4 vs. 64.2 ± 14.4 mg·dl−1), respectively. In addition, the CRD increased total cholesterol (151.5 ± 23.0 vs. 167.7 ± 38.2 mg·dl−1) and high-density lipoprotein cholesterol (46.3 ± 12.7 vs. 50.6 ± 15.5 mg·dl−1), but no differences were found with low-density lipoprotein cholesterol. Overall, our results show a 4-week CRD can favorably improve some markers of cardiovascular health in male FF.
Estimation of Undrained Shear Strength of Overconsolidated Clay Using a Maximum Excess Pore Pressure Method Based on Piezocone Penetration Test (CPTU)
Authors: Liu Lulu , Cai Guojun , Liu Xiaoyan , Li Xuepeng , Liu Songyu , Puppala Anand J. 
Published: August 2020

Abstract
Many methods can be used to evaluate the undrained shear strength (su) in unconsolidated or normally consolidated clay. However, among the many methods, few methods can be used to evaluate the su value in overconsolidated clay. In this paper, based on the piezocone penetration test (CPTU), the maximum excess pore pressure method (Δumax) was adopted to estimate the su in overconsolidated clay. In addition, three different test sites (in China) with overconsolidated clays were selected to verify the feasibility of this method. The test results show that the maximum pore pressure cone factor (NΔumax) significantly affected the evaluation of su. Moreover, the NΔumax values (8.10, 8.70, and 8.44) for 3 test sites in Yancheng, Nanjing, and Changzhou were obtained and can provide a valuable reference for evaluating su for in situ tests with overconsolidated clay.
Breast Cancer Diagnosis Based on Feature Extraction Using Dynamic Models of Thermal Imaging and Deep Autoencoder Neural Networks
Authors: Ghayoumi Zadeh Hossein , Fayazi Ali , Binazir Bita , Yargholi Mostafa 
Published: August 2020

Abstract
Breast cancer is the most commonly diagnosed cancer among women worldwide. Diagnosing breast cancer at its earliest stages increases the chance for treatment. Thermography offers a method to consider screening strategies for this type of cancer. Analysis of breast thermography images is very effective to extract local information that helps to identify abnormalities related to the breast region. In this paper, first, a semiautomatic approach is proposed for separating the breast region according to the different morphological structures of the breast tissue. The stages of breast segmentation are then performed based on the classification of the presented morphologies, which used a series of dynamic images of a patient. In the following, feature extraction is performed based on the proposed model. The eight statistical characteristics are obtained from a series of separated images of a person’s breasts. The autoencoder neural network, which is an unsupervised deep-learning algorithm, is used to classify the thermography images as healthy and unhealthy. To analyze the proposed model, the Database For Mastology Research is used. The number of people surveyed was 196, including 41 cases of cancer and 155 healthy cases. Each person had 10 thermography pictures, and the total number of analyzed images was 1,960. The accuracy and specificity of the proposed method were 94.87 and 96.77 %, respectively. The simulation results show that the proposed model is able to provide a significant response to different morphologies of the breast tissue.
Approach to the Design and Manufacturing of Prosthetic Dental Restorations According to the Rules of Industry 4.0
Authors: Dobrzański Leszek A. , Dobrzański Lech B. 
Published: August 2020

Abstract
The paper contains an extensive, richly illustrated literature study, theoretical studies, and practical work on current development trends of technical support for dental prosthetics. Dentistry 4.0 is the concept closely inspired by the highest stage Industry 4.0 of the industrial revolution. An augmented holistic Industry 4.0 model, which takes into account all other aspects, i.e., materials, processes, and technological machines and their development and informatics service, was developed and presented. The basis for consideration is the analysis of the disease in the human stomatognathic system and the possibility of prosthetic treatment in the event of a partial or total loss of natural dentition. In several centers, independent work on the popularization of individual implants manufactured using information obtained using conical beam computed tomography (CBCT) is carried out. The developed procedure requires one to make a three-dimensional bone base model based on the CBCT tomogram and its connection with the three-dimensional model of the dentition and soft tissues in the oral cavity, prepared on the basis of impression material, and most preferably a three-dimensional scan directly from the mouth. The presented and fully digitized approach is a radical turnaround in both clinical procedures and the method of technical implant preparation using Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) methods and additive manufacturing technologies (AMT), including mainly Selective Laser Sintering (SLS) and stereolithography (SLA). The concept of hybrid multilayer biological-engineering composites is much more technologically advanced. The application of the principles of the augmented holistic Industry 4.0 model in modern dental engineering, according to the analysis, indicates a change in the traditional relationship between a dentist and dental engineer. The practical application of the Dentistry 4.0 approach is illustrated by projects regarding the manufacturing of a few dental restorations. The general conclusion indicates that the implementation of the ideas of Dentistry 4.0 following the assumptions of the augmented holistic model Industry 4.0 is inevitable and extremely beneficial.
Type B insulin resistance syndrome associated with connective tissue disease and psoriasis
Authors: Łebkowska Agnieszka , Krentowska Anna , Adamska Agnieszka , Lipińska Danuta , Piasecka Beata , Kowal-Bielecka Otylia , Górska Maria , Semple Robert K , Kowalska Irina 
Published: August 2020

Summary
Type B insulin resistance syndrome (TBIR) is characterised by the rapid onset of severe insulin resistance due to circulating anti-insulin receptor antibodies (AIRAs). Widespread acanthosis nigricans is normally seen, and co-occurrence with other autoimmune diseases is common. We report a 27-year-old Caucasian man with psoriasis and connective tissue disease who presented with unexplained rapid weight loss, severe acanthosis nigricans, and hyperglycaemia punctuated by fasting hypoglycaemia. Severe insulin resistance was confirmed by hyperinsulinaemic euglycaemic clamping, and immunoprecipitation assay demonstrated AIRAs, confirming TBIR. Treatment with corticosteroids, metformin and hydroxychloroquine allowed withdrawal of insulin therapy, with stabilisation of glycaemia and diminished signs of insulin resistance; however, morning fasting hypoglycaemic episodes persisted. Over three years of follow-up, metabolic control remained satisfactory on a regimen of metformin, hydroxychloroquine and methotrexate; however, psoriatic arthritis developed. This case illustrates TBIR as a rare but severe form of acquired insulin resistance and describes an effective multidisciplinary approach to treatment.

Learning points:

We describe an unusual case of type B insulin resistance syndrome (TBIR) in association with mixed connective tissue disease and psoriasis.

Clinical evidence of severe insulin resistance was corroborated by euglycaemic hyperinsulinaemic clamp, and anti-insulin receptor autoantibodies were confirmed by immunoprecipitation assay.

Treatment with metformin, hydroxychloroquine and methotrexate ameliorated extreme insulin resistance.
Genome-Wide Duplication of Allotetraploid Brassica napus Produces Novel Characteristics and Extensive Ploidy Variation in Self-Pollinated Progeny
Authors: Yin Liqin , Zhu Zhendong , Luo Xuan , Huang Liangjun , Li Yu , Mason Annaliese S , Yang Jin , Ge Xianhong , Long Yan , Wang Jisheng , Zou Qiong , Tao Lanrong , Kang Zeming , Tang Rong , Wang Maolin , Fu Shaohong 
Published: August 2020

Abstract
Whole genome duplications (WGDs) have played a major role in angiosperm species evolution. Polyploid plants have undergone multiple cycles of ancient WGD events during their evolutionary history. However, little attention has been paid to the additional WGD of the existing allopolyploids. In this study, we explored the influences of additional WGD on the allopolyploid Brassica napus. Compared to tetraploid B. napus, octoploid B. napus (AAAACCCC, 2n = 8x =76) showed significant differences in phenotype, reproductive ability and the ploidy of self-pollinated progeny. Genome duplication also altered a key reproductive organ feature in B. napus, that is, increased the number of pollen apertures. Unlike autopolyploids produced from the diploid Brassica species, the octoploid B. napus produced from allotetraploid B. napus had a relatively stable meiotic process, high pollen viability and moderate fertility under self-pollination conditions, indicating that sub-genomic interactions may be important for the successful establishment of higher-order polyploids. Doubling the genome of B. napus provided us with an opportunity to gain insight into the flexibility of the Brassica genomes. The genome size of self-pollinated progeny of octoploid B. napus varied greatly, and was accompanied by extensive genomic instability, such as aneuploidy, mixed-ploidy and mitotic abnormality. The octoploid B. napus could go through any of genome reduction, equilibrium or expansion in the short-term, thus providing a novel karyotype library for the Brassica genus. Our results reveal the short-term evolutionary consequences of recurrent polyploidization events, and help to deepen our understanding of polyploid plant evolution.
Locating the Sex Determining Region of Linkage Group 12 of Guppy (Poecilia reticulata)
Authors: Charlesworth Deborah , Bergero Roberta , Graham Chay , Gardner Jim , Yong Lengxob 
Published: August 2020

Abstract
Despite over 100 years of study, the location of the fully sex-linked region of the guppy (Poecilia reticulata) carrying the male-determining locus, and the regions where the XY pair recombine, remain unclear. Previous population genomics studies to determine these regions used small samples from recently bottlenecked captive populations, which increase the false positive rate of associations between individuals’ sexes and SNPs. Using new data from multiple natural populations, we show that a recently proposed candidate for this species’ male-determining gene is probably not completely sex-linked, leaving the maleness factor still unidentified. Variants in the chromosome 12 region carrying the candidate gene sometimes show linkage disequilibrium with the sex-determining factor, but no consistently male-specific variant has yet been found. Our genetic mapping with molecular markers spread across chromosome 12 confirms that this is the guppy XY pair. We describe two families with recombinants between the X and Y chromosomes, which confirm that the male-determining locus is in the region identified by all previous studies, near the terminal pseudo-autosomal region (PAR), which crosses over at a very high rate in males. We correct the PAR marker order, and assign two unplaced scaffolds to the PAR. We also detect a duplication, with one copy in the male-determining region, explaining signals of sex linkage in a more proximal region.
A Novel Mechanism for Activation of Myosin Regulatory Light Chain by Protein Kinase C-Delta in Drosophila
Authors: Vaziri Pooneh , Ryan Danielle , Johnston Christopher A , Cripps Richard M 
Published: August 2020

Abstract
Myosin is an essential motor protein, which in muscle is comprised of two molecules each of myosin heavy-chain (MHC), the essential or alkali myosin light-chain 1 (MLC1), and the regulatory myosin light-chain 2 (MLC2). It has been shown previously that MLC2 phosphorylation at two canonical serine residues is essential for proper flight muscle function in Drosophila; however, MLC2 is also phosphorylated at additional residues for which the mechanism and functional significance is not known. We found that a hypomorphic allele of Pkcδ causes a flightless phenotype; therefore, we hypothesized that PKCδ phosphorylates MLC2. We rescued flight disability by duplication of the wild-type Pkcδ gene. Moreover, MLC2 is hypophosphorylated in Pkcδ mutant flies, but it is phosphorylated in rescued animals. Myosin isolated from Pkcδ mutant flies shows a reduced actin-activated ATPase activity, and MLC2 in these myosin preparations can be phosphorylated directly by recombinant human PKCδ. The flightless phenotype is characterized by a shortened and disorganized sarcomere phenotype that becomes apparent following eclosion. We conclude that MLC2 is a direct target of phosphorylation by PKCδ, and that this modification is necessary for flight muscle maturation and function.
Late Roman pottery from Room III/North at the Visegrád-Gizellamajor fort
Authors: Ottományi Katalin 
Published: August 2020

AbstractPottery at the late Roman fort of Visegrád-Gizellamajor contains both forms common in the 4th century as well as new ones, which appear at the turn of the 4th and 5th centuries. On traditional Roman household pottery and glazed vessels new surface ornaments (incised and notched) and new designs (fired yellowish-white, very gritty fabric) appear. Additionally, there are vessels with smoothed and smoothed-in ornaments. Although the excavators distinguished various layers in the fort, pottery from the layers often fit together. What survived to the greatest extent were the materials from the upper destruction debris. Room III of the north wing was a later addition to the fort; hence its pottery can be dated from the Valentinian period until the Hun period.
Constantius heros – Notes on the history of Pannonia in the 5th century
Authors: Kovács Péter 
Published: August 2020

AbstractIn his paper the author deals with a lost late Roman funerary text, Constantius’ epitaph. Based on the manuscript tradition, the epitaph was probably erected in Rome or more rather at Ravenna. Constantius was an important military commander of Western Rome in the 5thcentury and he had an important role in the fifth century history of Roman Pannonia as he fought against the Barbarians, most probably the Huns who settled down in Pannonia. The earlier identifications must be rejected but his person – unfortunately – cannot be identified with Flavius Constantius Felix. On the other hand, the events (fights against the Huns and the sea-going Vandals) mentioned in the funerary epigram fit perfectly into the period at the beginning of Valentinian III’s reign.
Environmental historical analysis of the Sarmatian and Gepids settlement of Rákóczifalva
Authors: Tugya Beáta , Náfrádi Katalin , Gulyás Sándor , Törőcsik Tünde , Pál Sümegi Balázs , Pomázi Péter , Sümegi Pál 
Published: August 2020

AbstractWe present the results of the environmental historical and geoarchaeological analysis of Rákóczifalva-Bagi- földek and Rákóczifalva-Rokkant-földek archeological sites in Jász-Nagykun-Szolnok County.1 They were discovered in the course of several hectares of archaeological excavations related to the Roman Age and Migration Period, especially the Sarmatian and the Gepids era. A significant number of Gepids sites and finds2 were found in both the investigated areas and the wider area of the site, in the middle reach of the Tisza valley. So the geoarchaeological and environmental historical analysis of the Sarmatian and Late-Sarmatian and Gepids sites in Rákóczifalva can also provide a model for the settling strategy and lifestyle of the Sarmatian and Gepids communities.3 The purpose of our work is to present how geoarchaeological and environmental historical factors impacted local settling and lifestyles in the Gepids communities and Sarmatian-Late Sarmatian communities as well4 during the Roman Age and the Migration Period. In addition, to demonstrate the relationship of the Sarmatian and Gepids communities and their environment in the Rákóczifalva site compared to other Gepids5 and Sarmatian and Late Sarmatian communities in the Great Hungarian Plain.6Based on the number of objects containing animal bones and the amount of bones found in them, we can reconstruct considerable settling in the Celtic, Sarmatian, Gepids, Avar and Arpadian periods. The number of objects from the Linear Pottery culture (Great Hungarian Plain) and the Bodrogkeresztúr culture is high; however, the number of animal bones is low. On the basis of the bones discovered, we can count on a smaller settlement during the Tiszapolgár culture, the Hunyadihalom group, the Halomíros culture, the Gava culture and during the Scythians period.In this paper, we present the results of the Sarmatian, Late Sarmatian and the Gepid findings since the largest number of animal bones (except the Avar period) turned up from these periods. Our aim was to compare the animal husbandry, meat consumption and hunting habits of the Oriental origin Sarmatians and the Germanic Gepids communities. Bone artefacts and bone anvils have been found in the archaeological material of both ethnic groups.
Fluorite – A marketable mineral commodity from the central region of medieval Hungary
Authors: Ritoók Ágnes 
Published: August 2020

AbstractSeveral types of mineral beads can be found among the 11th–12th-century grave assemblages of the Carpathian Basin. This paper examines the distribution of fluorite beads representing one type in Central and Eastern Europe. The distribution patterns have enabled the identification of the source of the raw material and they also outline the period’s main trade routes
Shear modulus analysis of cross-laminated timber using picture frame tests and finite element simulations
Authors: Turesson Jonas , Berg Sven , Björnfot Anders , Ekevad Mats 
Published: August 2020

AbstractDetermining the mechanical properties of cross-laminated timber (CLT) panels is an important issue. A property that is particularly important for CLT used as shear walls in buildings is the in-plane shear modulus. In this study, a method to determine the in-plane shear modulus of 3- and 5-layer CLT panels was developed based on picture frame tests and a correction factor evaluated from finite element simulations. The picture frame test is a biaxial test where a panel is simultaneously compressed and tensioned. Two different testing methods are simulated by finite elements: theoretical pure shear models as a reference cases and picture frame models to simulate the picture frame test setup. An equation for calculating the shear modulus from the measured shear stiffnesses in the picture frame tests is developed by comparisons between tests and finite element simulations of the CLT panels. The results show that pure shear conditions are achieved in the central region of the panels. No influence from the size of the tested panels is observed in the finite element simulations.
Patrimonio y comunidad patrimonial: construcción de una identidad compartida en un entorno rural
Authors: Marqués Valea Xulia , Castro-Fernández Belén María , López-Facal Ramón Vicente 
Published: August 2020

Se presenta una evaluación de un proyecto educativo basado en la identificación con el patrimonio cultural inmaterial de un centro situado en una comunidad rural. Se analizan los aprendizajes de los alumnos sobre el carnaval tradicional de la comarca del Ulla (A Coruña). Se valora en qué medida el proyecto tiene impacto en la sociedad y el proceso de identificación del alumnado con las tradiciones de su entorno. La experiencia se ha desarrollado fuera del horario lectivo, y forma parte de un proyecto más amplio iniciado en 2016. Se pretende promover la construcción de una identidad inclusiva en una comunidad rural a partir del patrimonio cultural local, basada en el diálogo intergeneracional. Para ello es fundamental la implicación de la comunidad con el centro educativo. Participaron 44 escolares de educación primaria y secundaria y 22 vecinos adultos. Para tomar datos se emplea una metodología mixta mediante cuestionarios, narrativa con representación gráfica y grupo de discusión. Los resultados muestran la importancia y eficacia de las comunidades de aprendizaje que trascienden el trabajo dentro de las aulas. La colaboración de familiares y vecinos permite compensar la falta de participación del profesorado.Palabras clave: Evaluación de proyecto, Educación patrimonial, Educación basada en el lugar, Comunidad rural, Diálogo intergeneracional.
Earthquakes Induced by Wastewater Injection, Part I: Model Development and Hindcasting
Authors: Grigoratos Iason , Rathje Ellen , Bazzurro Paolo , Savvaidis Alexandros 
Published: August 2020

ABSTRACTIn the past decade, several parts of central United States, including Oklahoma, have experienced unprecedented seismicity rates, following an increase in the volumes of wastewater fluids that are being disposed underground. In this article, we present a semi-empirical model to hindcast the observed seismicity given the injection time history. Our proposed recurrence model is a modified version of the Gutenberg–Richter relation, building upon the seismogenic index model, which predicts a linear relationship between the number of induced events and the injected volume. Our methodology accounts for the effects of spatiotemporal pore-pressure diffusion, the stressing-rate dependency of the time lag between injection and seismicity rate changes, and the rapid cessation of seismicity upon unloading. We also introduced a novel multiscale regression, which enabled us to produce grid-independent results of increased spatial resolution. Although the model is generic to be applicable in any region and has essentially only two free parameters for spatial calibration, it matches the earthquake time history of Oklahoma well across various scales, for both increasing and decreasing injection rates. In the companion paper (Grigoratos, Rathje, et al., 2020), we employ the model to distinguish the disposal-induced seismicity from the expected tectonic seismicity and test its forecasting potential.