bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diversity of Cryphonectria parasitica in callused chestnut blight cankers on European and American chestnut
Authors: Ježić Marin , Kolp Matthew , Prospero Simone , Sotirovski Kiril , Double Mark , Rigling Daniel , Risteski Mihajlo , Karin‐Kujundžić Valentina , Idžojtić Marilena , Poljak Igor , Ćurković‐Perica Mirna 
Published: November 2019

AbstractInfection of American and European chestnuts with the chestnut blight fungus Cryphonectria parasitica results in the formation of cankers, lesions caused by the growth of mycelia within bark tissue of the host plant. Infection of the fungus with Cryphonectria hypovirus 1 (CHV‐1) results in conversion of the mycelial phenotype from virulent to hypovirulent, thus allowing production of callus around cankers as a reaction by infected trees, rendering active into inactive cankers. In this study, we sampled one USA and six European chestnut stands and assessed frequency of hypovirulent C. parasitica and diversity of vegetative compatibility (vc) types present in calluses and randomly sampled cankers. Callused cankers on C. dentata at West Salem in the USA yielded significantly more hypovirulent C. parasitica isolates compared with four sampled populations on C. sativa, while all six sampled European populations did not show any statistically significant differences among themselves. We observed no correlation between hypovirulence frequencies in randomly sampled cankers and calluses, as well as no correlation of C. parasitica vc type diversity in calluses and residential populations of the fungus. Furthermore, even though we have observed calluses with more than one vc type, they do not occur regularly. Even when present in C. parasitica populations with high vc type diversity, no more than three different vc types were observed in a single callus.
Efficacy of pharmacists' assessment and intervention based on Screening Tool for Older Persons' Appropriate Prescriptions for Japanese compared with Screening Tool for Older Persons' Appropriate Prescriptions for Japanese criteria version 2 in older patients with cardiovascular disease
Authors: Kimura Takeshi , Ogura Fumie , Kukita Yukiko , Takahashi Tomoko , Yamamoto Kazuhiro , Ioroi Takeshi , Yano Ikuko 
Published: November 2019

AimThis study aimed to evaluate the efficacy of pharmacists' assessment and intervention using the Screening Tool for Older Persons' Appropriate Prescriptions for Japanese (STOPP‐J) to detect and correct potentially inappropriate medications (PIM) compared with the Screening Tool of Older Persons' Potentially Inappropriate Prescriptions (STOPP) criteria version 2.MethodsA prospective observational study was carried out at a medical unit of Cardiovascular Surgery and Cardiovascular Internal Medicine in a Japanese university hospital involving new inpatients aged ≥65 years prescribed one or more daily medication. Pharmacists detected PIM based on STOPP‐J and STOPP criteria version 2, and corrected them with physicians. The number of patients with PIM, the content and changes in PIM were compared between both criteria.ResultsOverall, 230 patients were included (mean age 75.4 years, 162 men, mean number of medications 8.3). STOPP‐J detected significantly more patients with PIM than STOPP criteria version 2 (122 [53%] vs 75 [33%], P < 0.001). The number of PIM based on STOPP‐J was 232, the physicians were recommended to change 61 (26%) and 50 (22%) were changed. Meanwhile, the number of PIM based on STOPP criteria version 2 was 133, the physicians were recommended to change 61 (46%) and 54 (41%) were changed. Several medications detected as PIM using STOPP‐J were not detected using STOPP criteria version 2.ConclusionsSTOPP‐J detected significantly more patients with PIM than STOPP criteria version 2, and pharmacists' assessment and intervention based on STOPP‐J were suggested to be effective for detecting and correcting PIM. Geriatr Gerontol Int 2019; 19: 1101–1107.
Association of trajectories of cognitive function with cause‐specific mortality and medical and long‐term care costs
Authors: Taniguchi Yu , Kitamura Akihiko , Ishizaki Tatsuro , Fujiwara Yoshinori , Shinozaki Tomohiro , Seino Satoshi , Mitsutake Seigo , Suzuki Hiroyuki , Yokoyama Yuri , Abe Takumi , Ikeuchi Tomoko , Yokota Isao , Matsuyama Yutaka , Shinkai Shoji 
Published: November 2019

AimCognitive decline increases mortality risk through dementia‐related pathways and might be associated with increased healthcare costs. Using up to 12 years of repeated measures data, we identified trajectories in cognitive function among community‐dwelling older Japanese adults. We then examined whether these trajectories were associated with all‐cause and cause‐specific mortality, and differences in healthcare costs.MethodsA total of 1736 adults aged ≥65 years who were free of disabling dementia completed annual assessments during 2002–2014. Cognitive function was assessed with the Mini‐Mental State Examination. The average number of follow‐up assessments was 3.9, and the total number of observations was 6824 during the follow‐up period.ResultsWe identified five trajectory patterns in cognitive function (high, second, third, fourth, and low) during the 12‐year follow‐up period. The low (2.0%) and fourth (2.2%) trajectory groups had higher hazard ratios for cardiovascular disease mortality, and hazard ratios for other cause mortality were significantly higher for the third (16.8%) and second (38.8%) trajectory groups than for the high trajectory group (40.3%). Until 5 years of follow up, participants in the two lower‐trajectory groups had higher mean combined monthly medical and long‐term care costs. After 8 years of follow up, mean costs were highest for the third trajectory.ConclusionsThe risk of death from cardiovascular disease was higher in the two lower‐trajectory groups in cognitive function, and they showed higher healthcare costs during the first 5 years of follow up. After 8 years of follow up, the third trajectory had the highest healthcare costs, perhaps because of hospitalizations attributable to gradual cognitive decline. Geriatr Gerontol Int 2019; 19: 1236–1242.
The influence of front‐of‐pack portion size images on children's serving and intake of cereal
Authors: McGale Lauren Sophie , Smits Tim , Halford Jason Christian Grovenor , Harrold Joanne Alison , Boyland Emma Jane 
Published: November 2019

SummaryBackgroundConsumption of large portions of energy‐dense foods promotes weight gain in children. Breakfast cereal boxes often show portions much larger than the recommended serving size.ObjectiveThis experimental study investigated whether front‐of‐package portion size depictions influence children's self‐served portions and consumption.MethodsIn a between‐subjects design, 41 children aged 7‐11 years (M= 9.0 ± 1.5y) served themselves breakfast cereal from a box, the front of which depicted either a recommended serving size of cereal (30g) or a larger, more typical front‐of‐pack portion (90g). Cereal served and consumed and total caloric intake (including milk) was recorded. Height and weight, demographic information and measures of children's food responsiveness and enjoyment of food were collected.ResultsMANOVA revealed that children exposed to the larger portion size served themselves (+7g, 37%) and consumed (+6g, 63%) significantly more cereal than those exposed to the smaller portion. Despite this, overall caloric intake (milk included) did not differ between conditions, and no other measured variables (hunger, BMI) significantly affected the outcomes.ConclusionThis study provides novel evidence of the influence portion‐size depictions on food packaging have on children's eating behaviour. This offers possible avenues for intervention and policy change; however, more research is needed.
Influenza in patients with cancer after 2009 pandemic AH1N1: An 8‐year follow‐up study in Mexico
Authors: Ángeles‐Sistac Diego , Martin‐Onraet Alexandra , Cornejo‐Juárez Patricia , Volkow Patricia , Pérez‐Jimenez Carolina , Vilar‐Compte Diana 
Published: November 2019

AbstractBackgroundImmunosupressed patients are at high risk of influenza‐related complications. Influenza AH1N1 has been hypothesized to induce worse outcomes in patients with malignancies, but after the A(H1N1)pdm09 few publications have analyzed the presentation and complications related to influenza afterward.ObjectivesWe aimed to describe the characteristics, risk factors, and outcomes of influenza in an oncologic center after the 2009 pandemic and to compare our case distribution to the National community acquired influenza databases in Mexico and the United States.MethodsWe reviewed the cases of confirmed influenza in patients with cancer from an oncological center in Mexico from April 2009 to April 2017. Data on severity and influenza type, malignancy, comorbidities, and outcomes were recorded. We correlated data between the Centers for Disease Control and Prevention (CDC) in the United States and SISVEFLU (Influenza Surveillance Program) in Mexico.ResultsOne hundred eighty‐eight patients were included; 75 (39.9%) had a solid neoplasm and 113 (60.1%) had hematologic malignancies. AH1N1 was the most frequent influenza type (54.2%). Patients with hematologic malignancies had more pneumonia (55% vs 25%, P < .001), needed more hospitalizations (75% vs 39% P < .001), had higher all‐cause mortality at 30 days (20% vs 9% P = .048) and influenza‐associated mortality (17% vs 7% P = .041). Thirty (16%) patients died within 30 days, and 24 (12.7%) were related to influenza. Influenza type was not associated with worse outcomes. Yearly occurrence of influenza reported by the CDC and SISVEFLU showed a significant correlation (ρ = 0.823, P = .006).ConclusionsAH1N1 was the dominant serotype. Patients with hematologic malignancies had more severe influenza and presented worse outcomes. Annual SISVEFLU and CDC surveillance information showed a similar distribution of cases along time but influenza serotypes did not match for all seasons.
VEGF signalling enhances lesion burden in KRIT1 deficient mice
Authors: DiStefano Peter V. , Glading Angela J. 
Published: November 2019

AbstractThe exact molecular mechanisms underlying CCM pathogenesis remain a complicated and controversial topic. Our previous work illustrated an important VEGF signalling loop in KRIT1 depleted endothelial cells. As VEGF is a major mediator of many vascular pathologies, we asked whether the increased VEGF signalling downstream of KRIT1 depletion was involved in CCM formation. Using an inducible KRIT1 endothelial‐specific knockout mouse that models CCM, we show that VEGFR2 activation plays a role in CCM pathogenesis in mice. Inhibition of VEGFR2 using a specific inhibitor, SU5416, significantly decreased the number of lesions formed and slightly lowered the average lesion size. Notably, VEGFR2 inhibition also decreased the appearance of lesion haemorrhage as denoted by the presence of free iron in adjacent tissues. The presence of free iron correlated with increased microvessel permeability in both skeletal muscle and brain, which was completely reversed by SU5416 treatment. Finally, we show that VEGFR2 activation is a common downstream consequence of KRIT1, CCM2 and CCM3 loss of function, though the mechanism by which VEGFR2 activation occurs likely varies. Thus, our study clearly shows that VEGFR2 activation downstream of KRIT1 depletion enhances the severity of CCM formation in mice, and suggests that targeting VEGF signalling may be a potential future therapy for CCM.
Four transcription profile–based models identify novel prognostic signatures in oesophageal cancer
Authors: Liu Tongyan , Fang Panqi , Han Chencheng , Ma Zhifei , Xu Weizhang , Xia Wenjia , Hu Jingwen , Xu Youtao , Xu Lin , Yin Rong , Wang Siwei , Zhang Qin 
Published: November 2019

AbstractOesophageal cancer (ESCA) is a clinically challenging disease with poor prognosis and health‐related quality of life. Here, we investigated the transcriptome of ESCA to identify high risk‐related signatures. A total of 159 ESCA patients of The Cancer Genome Atlas (TCGA) were sorted by three phases. In the discovery phase, differentially expressed transcripts were filtered; in the training phase, two adjusted Cox regressions and two machine leaning models were used to construct and estimate signatures; and in the validation phase, prognostic signatures were validated in the testing dataset and the independent external cohort. We constructed two signatures from three types of RNA markers by Akaike information criterion (AIC) and least absolute shrinkage and selection operator (LASSO) Cox regressions, respectively, and all candidate markers were further estimated by Random Forest (RFS) and Support Vector Machine (SVM) algorithms. Both signatures had good predictive performances in the independent external oesophageal squamous cell carcinoma (ESCC) cohort and performed better than common clinicopathological indicators in the TCGA dataset. Machine learning algorithms predicted prognosis with high specificities and measured the importance of markers to verify the risk weightings. Furthermore, the cell function and immunohistochemical (IHC) staining assays identified that the common risky marker FABP3 is a novel oncogene in ESCA.
Household vegetable processing practices influencing occurrence of pesticide residues in ready‐to‐eat vegetables
Authors: Kiwango Purificator A. , Kassim Neema , Kimanya Martin E. 
Published: November 2019

AbstractInfluence of vegetable processing on pesticide residues in ready‐to‐eat vegetables studied at the experimental level does not necessarily reflect actual situation at household level. This study assessed influence of household vegetable processing practices on pesticide residues in ready‐to‐eat vegetables at household level in Arusha, Tanzania. Data on vegetable handling practices were collected through observations and physical interviews in 70 households. Samples of raw and ready‐to‐eat vegetables were collected from the households for pesticide residues analysis. Detectable pesticide levels were found in 46% of raw and 14% of ready‐to‐eat vegetable samples. Pesticide residues detected were in the groups of organophosphates (22.8%), pyrethroids (14.3%), organochlorines (7.14%), benzoic acids (7.14%), and carbamates (5.71%). Unauthorized pesticides (dichlorvos, tetramethrin, and bendiocarb) and environmentally persistent pesticide (dieldrin) were found at levels above their respective maximum residue levels. Washing of vegetables twice or more (p = .01) or peeling (p = .008) was significantly associated with reduction of pesticide residues. There was a significant association between occurrence of pesticide residues in ready‐to‐eat vegetables and washing of minor ingredients with the water used to wash major ingredients (p = .001). Household practices of washing of vegetables with portable water followed with peeling can reduce pesticide residue levels significantly.
Effectiveness of a new cosmetic treatment for melasma
Authors: Berardesca Enzo , Rigoni Corinna , Cantù Alessandra , Cameli Norma , Tedeschi Aurora ,   Donne Dermatologhe Italia, Laureti Tiziana 
Published: November 2019

AbstractBackgroundMelasma treatment is difficult due to extended treatment periods, suboptimal adherence, inconsistent results, and frequent relapses. Kojic acid has been shown to be effective in reducing melasma severity and is now increasingly used in cosmetic treatments.AimsThe purpose of the present study was to evaluate the effectiveness of a new cosmetic treatment for melasma at 45 and 90 days.MethodsMulticenter prospective study across 20 dermatology clinics/ambulatories. One hundred patients with mild‐to‐moderate melasma were evaluated. The primary endpoints were changes in mean modified melasma area and severity index (mMASI) score and patient‐reported satisfaction at 45 and 90 days.ResultsThe mean age of patients was 45.19 ± 11.5 years. Most patients were female and Caucasian. Patients presented mixed (65%), epidermal (26%), and dermal (4%) types of melasma. Triggering factors were hormonal contraception (33%), pregnancy (31%), and pharmacological treatment (11%); mean disease duration was 6.7 ± 6.8 years. Overall, a statistically significant decrease in mean mMASI scores was seen at 45 (2.19 ± 0.182 vs 3.29 ± 0.267, P < .0001) and 90 days (1.27 ± 0.128 vs 3.29 ± 0.267, P < .00001). The highest reduction in mMASI scores was observed in patients with dermal melasma. IGA scores showed a statistically significant improvement in pigmentation at 90 days (P < .00001).ConclusionThe novel cosmetic treatment was associated with the improvement of melasma, as assessed by mMASI.
Vertical growth in mono‐and dizygotic twins: A longitudinal cephalometric cohort study
Authors: Hersberger‐Zurfluh Monika A. , Papageorgiou Spyridon N. , Motro Melih , Kantarci Alpdogan , Will Leslie A. , Eliades Theodore 
Published: November 2019

AbstractObjectiveThe aims of this longitudinal analysis of untreated monozygotic and dizygotic twins were to investigate vertical changes of the craniofacial structures during growth, to determine the concordance between genetically twins and to assess the genetic component for the various aspects of vertical growth.Settings and sample populationThe sample consisted of 34 pairs of untreated monozygotic twins (23 male, 11 female) and 30 untreated dizygotic siblings of multiple birth (8 male, 8 female and 14 mixed) from the Forsyth Moorrees Twin Study (1959‐1975); lateral cephalograms taken from 6 to 18 years of age were analysed at 3‐year intervals.Materials and MethodsCephalograms were traced, and longitudinal changes between twins in six angular and proportional vertical cephalometric variables (SN‐NL, ML‐NL, SN‐ML, y‐axis, PFH/AFH and LAFH/AFH) were analysed with intraclass correlation coefficients and linear regression modelling.ResultsThe concordance between monozygotic/dizygotic twins at 18 years of age was moderate to high with intraclass correlation coefficient values between 0.51 and 0.66. Additionally, sex differences in concordance at 18 years of age were found for three variables. High heritability (66%‐79%) was observed for 5 of the 6 variables (LAFH/AFH, ML‐NL, y‐axis, SN‐ML, PFH/AFH), while SN‐NL showed limited heritability (34%).ConclusionsAlthough monozygotic/dizygotic twins share at least part of their genetic material, differences in the vertical dimension were found. This supports the complex developmental mechanism of the human face and the varying influence of genetic and environmental factors.
Safety of older people at home: An integrative literature review
Authors: Kivimäki Taina , Stolt Minna , Charalambous Andreas , Suhonen Riitta 
Published: November 2019

AbstractAimThe aim of this review was to examine the relevant health literature, to describe safety in the homes of older and older people's perceptions and understanding of their safety at home based on current literature.BackgroundSafety is a multifaceted, basic need of older people living at home. Many studies are hospital focused and few focus on safety at home. Research on the safety of older people at home appears to be under‐researched.MethodsMEDLINE, CINAHL, Scopus and Web of Science databases from the earliest to August 2017 were investigated. The integrative literature review was conducted in December 2017. The full text of the remaining n = 93 papers was then screened for relevance by inclusion and exclusion criteria which reduced the number by 59 to n = 34.ResultsFour dimensions of safety at home were discovered, namely physical, social, emotional and mental, and cognitive safety. Safety dimensions had both positive and negative components. Older people's main wish was to be able to live in their own home for as long as possible. Their perceptions of safety at home was categorised as active living, coping at home, managed living and the knowledge of the existence of disease.ConclusionsThe safety of older people at home is a worldwide concern. Identification of safety issues can assist in developing measures to help people stay at home for longer as they age. The management of this would need to take account of all four dimensions of safety, in ways that promote ageing at home.Implications for practiceLearning, understanding and developing new strategies about safety affect everyone who visits the home of older people, and stakeholders have an important role to identify safety risks.
Importance of the Occipitoaxial Angle and Posterior Occipitocervical Angle in Occipitocervical Fusion
Authors: Tang Chao , Li Guang Zhou , Liao Ye Hui , Tang Qiang , Ma Fei , Wang Qing , Zhong De Jun 
Published: November 2019

ObjectiveTo observe the effects of occipitoaxial angle (O‐C2 angle, OC2A) and posterior occipitocervical angle (POCA) selection on postoperative clinical efficacy and lower cervical curvature in patients with acute acquired atlantoaxial dislocation after occipitocervical fusion (OCF).MethodsA total of 150 healthy subjects without cervical disease (healthy group) were randomly selected based on gender and age. Three spine surgeons measured the OC2A and POCA of the healthy group and averaged the values. A total of 30 patients with an average age of 51.0 years (range, 18–70 years; 16 male and 14 female) with trauma or rheumatoid arthritis (disease group) who underwent occipitocervical fusion (OCF) for atlantoaxial dislocation between January 2012 and June 2016 were reviewed. OC2A, POCA, and cervical spinal angle (CSA) were measured postoperative/soon after surgery and ambulation, and at the final follow‐up visit. The preoperative and final follow‐up visual analog scale (VAS), Japanese orthopedics association score (JOA), neck disability index (NDI), and dCSA (change of CSA from postoperative/soon after surgery and ambulation to final follow‐up) were recorded.ResultsThe values of OC2A and POCA in 150 healthy subjects were 14.5° ± 3.7° and 108.2° ± 8.1°, respectively, and the 95% confidence interval (CI) were 7.2°–21.8° and 92.3°–124.0°, respectively. There was a negative correlation between OC2A and POCA (r = −0.386, P < 0.001). There were 18 patients (group one) of ideal OC2A and POCA (both within 95% CI of the healthy group) postoperative/soon after surgery and ambulation with a mean follow‐up time of 26.3 ± 20.9 months in disease group. The remaining patients (group two) with a mean follow‐up time of 31.3 ± 21.3 months. There was no statistically significant difference in the baseline data as well as pre‐operative outcomes, including VAS score, JOA score, and NDI between the two groups. Likewise, the post‐operative outcomes in final follow‐up, including VAS and JOA score, had no distinct difference in the two groups. However, NDI (11.0 ± 2.9) in group two at the final follow‐up was significantly higher than that in group one (7.0 ± 2.3) (P < 0.001). And group two showed statistically greater dCSA (5.9 ± 7.5°) than group one (−2.3° ± 6.2°) (P = 0.003).ConclusionsThe negative correlation between OC2A and POCA plays an important role in maintaining the biodynamic balance of the occipital‐cervical region. OC2A and POCA should be controlled of a normal population in patients with acute acquired atlantoaxial dislocation during OCF, which can further improve the clinical efficacy and prevent loss of lower cervical curvature after surgery.