bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engaging Pathology Residents in Clinical Chemistry: The Essential Ingredient Is a Committed Teacher
Authors: Singh Gurmukh , Bollag Roni J , Savage Natasha M 
Published: August 2020

Abstract

Background
Pathology residents are thought to show a lack of interest in clinical chemistry, therefore potentially graduating from training programs unprepared to function as laboratory directors and clinical consultants.

Methods
A structured program of tutorials based primarily on Henry’s textbook, supplemented by recent review articles; a question bank of about 600 questions to emphasize key concepts; requirement for performing and presenting quality improvement projects; participation in on-site CAP inspections; review of reference laboratory test requests; and involving residents in scholarly activity have resulted in sustained, transferable, and significant improvements in engagement, knowledge, competence, and examination scores.

Results
The primary parameter for measuring change in resident competence and engagement were improvements in resident in-service examination (RISE) scores, publications in peer-reviewed journals, and receipt of awards. The revised program produced significant improvement in RISE scores in clinical chemistry, over and above the improvements in the general residency program. The residents were authors on 12 publications in peer-reviewed PubMed listed journals in the 5-year period since revision in the clinical chemistry curriculum compared to no publications in clinical chemistry in the 5-year period before the new curriculum. Over the past 2 years, 6 of the 11 publications by graduating residents were in clinical chemistry, and 6 of 7 awards for research were garnered by residents engaged in clinical chemistry investigations. All of the residents passed their clinical pathology boards on first attempt since the change compared to 2 failures in the prior 5-year period.

Conclusions
The structured program described here is important as a template that could be adopted by any pathology training program. The question bank developed by this program is a valuable and transferable aid. However, success of such a program is dependent on the commitment of a knowledgeable, dedicated, and passionate teacher.
Genetic variance and covariance components for carbon dioxide production and postweaning traits in Angus cattle
Authors: Donoghue Kath A , Bird-Gardiner Tracie , Herd Robert M , Hegarty Roger S , Arthur Paul F 
Published: August 2020

Abstract
This experiment investigated phenotypic and genetic relationships between carbon dioxide production, methane emission, feed intake, and postweaning traits in Angus cattle. Respiration chamber data on 1096 young bulls and heifers from 2 performance recording research herds of Angus cattle were analyzed to provide phenotypic and genetic parameters for carbon dioxide production rate (CPR; n = 425, mean 3,010 ± SD 589 g/d) and methane production rate (MPR; n = 1,096, mean 132.8 ± SD 25.2 g/d) and their relationships with dry matter intake (DMI; n = 1,096, mean 6.15 ± SD 1.33 kg/d), body weight (BW) and body composition traits. Heritability estimates were moderate to high for CPR (0.53 [SE 0.17]), MPR (0.31 [SE 0.07]), DMI (0.49 [SE 0.08]), yearling BW (0.46 [SE 0.08]), and scanned rib fat depth (0.42 [SE 0.07]). There was a strong phenotypic (0.83 [SE 0.02]) and genetic (0.75 [SE 0.10]) correlation between CPR and MPR. The correlations obtained for DMI with CPR and with MPR were high, both phenotypically (rp) and genetically (rg) (rp: 0.85 [SE 0.01] and 0.71 [SE 0.02]; rg (0.95 [SE 0.03] and 0.83 [SE 0.05], respectively). Yearling BW was strongly correlated phenotypically (rp ≥ 0.60) and genetically (rg &gt; 0.80) with CPR, MPR, and DMI, whereas scanned rib fat was weakly correlated phenotypically (rp &lt; 0.20) and genetically (rg ≤ 0.20) with CPR, MPR, and DMI. The strong correlation between both CPR and MPR with DMI confirms their potential use as proxies for DMI in situations where direct DMI recording is not possible such as on pasture.
Evaluation of a decision support system for precision feeding of gestating sows
Authors: Gaillard Charlotte , Quiniou Nathalie , Gauthier Raphaël , Cloutier Laetitia , Dourmad Jean-Yves 
Published: August 2020

Abstract
Precision feeding (PF) with the daily mixing of 2 diets with different lysine content (high (H) or low (L)) was previously reported for growing pigs to reduce protein intake and N excretion compared with a conventional feeding (CF) based on a single diet (C). Using a simulation approach based on farm data, the objective of the present paper was to describe and evaluate a decision support system for the PF of gestating sows allowing the daily distribution of a tailored ration to each sow. Two datasets, 1 of 2,511 gestations (farm A) and 1 of 2,528 gestations (farm B), reporting sows’ characteristics at insemination and objectives at farrowing were used as inputs for a Python model. This model, mainly based on InraPorc, calculates the nutrient requirements of each sow over gestation and simulates the impact of PF in comparison to CF. Simulated diets L, H, and C contained 3.0, 6.5, and 4.8 g/kg of standardized ileal digestible lysine (SID Lys) and 2.0, 3.3, and 2.5 g/kg of standardized total tract digestible phosphorus (STTD-P), respectively. The influence of farm, parity, gestation week, and their interactions, on calculated SID Lys and STTD-P requirements was analyzed applying a mixed model. The calculated SID Lys and STTD-P requirements increased markedly in the last third of gestation (P &lt; 0.01) and were higher for primiparous than for multiparous sows, unless after week 14 for STTD-P requirement. The calculated SID AA and mineral requirements were lower for farm B than farm A (respectively, 2.94 vs. 3.08 g/kg for SID Lys and 1.30 vs. 1.35 g/kg for STTD-P, P &lt; 0.01). On average, feed L represented 86% and 92% of the feed projected to be delivered by the PF strategy in farms A and B, respectively. Compared to CF, average calculated dietary SID Lys content was lowered by 27% and 32% with PF, for farms A and B, respectively, while average calculated dietary phosphorus content was lowered by 13% and 16%. The simulated proportions of sows in excess and deficient in SID Lys were reduced with PF. Compared to CF, the PF strategy allowed for a 3.6% reduction in simulated feed cost per sow during gestation, and reduced nitrogen and phosphorus intake (by 11.0% and 13.8%, respectively) and excretion (by 16.7% and 15.4%, respectively). To conclude, these simulations indicate that PF of gestating sow appears to be relevant to meet the amino acid requirement while reducing feed cost, and supplies and excretion of nitrogen and phosphorus.
The Impact of COVID-19 on Pediatric Adherence and Self-Management
Authors: Plevinsky Jill M , Young Melissa A , Carmody Julia K , Durkin Lindsay K , Gamwell Kaitlyn L , Klages Kimberly L , Ghosh Shweta , Hommel Kevin A 
Published: August 2020

Abstract
The COVID-19 pandemic has presented unique circumstances that have the potential to both positively and negatively affect pediatric adherence and self-management in youth with chronic medical conditions. The following paper discusses how these circumstances (e.g., stay-at-home orders, school closures, changes in pediatric healthcare delivery) impact disease management at the individual, family, community, and healthcare system levels. We also discuss how barriers to pediatric adherence and self-management exacerbated by the pandemic may disproportionately affect underserved and vulnerable populations, potentially resulting in greater health disparities. Given the potential for widespread challenges to pediatric disease management during the pandemic, ongoing monitoring and promotion of adherence and self-management is critical. Technology offers several opportunities for this via telemedicine, electronic monitoring, and mobile apps. Moreover, pediatric psychologists are uniquely equipped to develop and implement adherence-promotion efforts to support youth and their families in achieving and sustaining optimal disease management as the current public health situation continues to evolve. Research efforts addressing the short- and long-term impact of the pandemic on pediatric adherence and self-management are needed to identify both risk and resilience factors affecting disease management and subsequent health outcomes during this unprecedented time.
Burden of Illness in Households With Severe Acute Respiratory Syndrome Coronavirus 2–Infected Children
Authors: Teherani Mehgan F , Kao Carol M , Camacho-Gonzalez Andres , Banskota Samridhi , Shane Andi L , Linam William M , Jaggi Preeti 
Published: August 2020

Abstract
We investigated of illness among household members of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–infected children receiving medical care (n = 32). We identified 144 household contacts (HCs): 58 children and 86 adults. Forty-six percent of HCs developed symptoms consistent with coronavirus disease. Child-to-adult transmission was suspected in 7 cases.
Idiopathic small bowel diaphragm disease: a case report
Authors: Marghich Omar , Maubert Alexandre , Amouzou Efoé-Ga Yawod Olivier , Denimal Louis , Benizri Emmanuel , Rahili Mohammed Amine 
Published: August 2020

Abstract
Small bowel diaphragm disease is a rare condition usually associated with the prolonged use of non-steroidal anti-inflammatory drugs (NSAID) and that can be mistaken and treated as other pathologies. We describe a case of a 64-year-old man with a prolonged course of pain and subacute bowel obstructions, without any history of NSAID usage, found to have a multiple diaphragmatic stricture in the small bowel.
Hybrid Surgical Simulator: A Temporal Bone Simulator Validation Study of the Stryker Surgical Simulator (S3)
Authors: Meyer Charles , Noda Francine , Folsom Craig R 
Published: August 2020

ABSTRACT

Introduction
The Stryker Surgical Simulator is a hybrid, temporal bone simulator that uses both tactile and haptic feedback combined with a computer interface. We sought to validate this simulator as an otolaryngology resident training tool for performing tympanomastoidectomy.

Materials and Methods
15 residents and staff performed five basic cortical mastoidectomies. Staff surgeons comprised the “expert” cohort and resident surgeons comprised the “trainee” cohort. Subjective evaluation of the face validity and content validity was assessed via pre- and postquestionnaires. Objective evaluation of content validity was assessed through grading of each temporal bone dissection specimen, comparing time to task completion, and calculating the rate of injury to critical structures. Study approved by the Institutional Review Board (2013.0001).

Results
Post hoc questionnaires showed that both staff and residents subjectively rated the simulator favorably on face validity, content validity, and all global assessment categories, though there were no significant distinctions between groups (P &gt; 0.05). The resident group had a significantly longer drilling time compared with the staff group throughout the series of tympanomastoidectomies (P = 0.008), and both groups showed a decrease in time to task completion with repetitive drilling. However, there were no significant differences in surgical performance as evaluated by a blinded senior neurotologist (P = 0.52). There were also no critical injuries recorded by the simulator in any of the 75 trials, preventing any evaluation on this measure.

Conclusions
Despite favorable subjective evaluations by both staff and residents, objective discrimination between experienced and novice participants was not achieved. This was likely in part due to inherent design flaws of the simulator. This emphasizes the potential shortcomings of surgical simulation models for highly technical procedures and points to the importance of intensive study and validation prior to incorporation of commercial training models into surgical training programs.
Optimal 1D Ly α forest power spectrum estimation – I. DESI-lite spectra
Authors: Karaçaylı Naim Göksel , Font-Ribera Andreu , Padmanabhan Nikhil 
Published: August 2020

ABSTRACT
The 1D Ly α forest flux power spectrum P1D is sensitive to scales smaller than a typical galaxy survey, and hence ties to the intergalactic medium’s thermal state, suppression from neutrino masses, and new dark matter models. It has emerged as a competitive framework to study new physics, but also has come with various challenges and systematic errors in analysis. In this work, we revisit the optimal quadratic estimator for P1D, which is robust against the relevant problems such as pixel masking, time evolution within spectrum, and quasar continuum errors. We further improve the estimator by introducing a fiducial power spectrum, which enables us to extract more information by alleviating the discreteness of band powers. We meticulously apply our method to synthetic Dark Energy Spectroscopic Instrument (DESI) spectra and demonstrate how the estimator overcomes each challenge. We further apply an optimization scheme that approximates the Fisher matrix to three elements per row and reduces computation time by 60 per cent. We show that we can achieve per cent precision in P1D with 5-yr DESI data in the absence of systematics and provide forecasts for different spectral qualities.
Revealing hidden variability in PWNe with spectral index maps
Authors: Guest Benson T , Safi-Harb Samar 
Published: August 2020

ABSTRACT
Pulsar wind nebulae (PWNe) are the synchrotron bubbles inflated by the rotational energy of a neutron star. Observing variability within them has previously been limited to cases of significant brightening, or the few instances where transient features are interpreted in terms of intrinsic motion or associated with variability from the pulsar. Jet and torus morphology are also only visible in cases of differing brightness with respect to the surrounding nebula and favourable alignment with our line of sight. Spectral map analysis involves binning observations with an adaptive algorithm to meet a signal limit and colouring the results based on the desired model parameter fits. Minute changes in spectral index become therefore apparent even in cases where brightness images alone do not suggest any underlying changes. We present a Chandra X-ray study of the PWNe in G21.5–0.9, Kes 75, G54.1+0.3, G11.2–0.3, and 3C 58, using archival observations accumulated over the ∼20-yr lifetime of the mission. With the spectral map analysis technique, we discover evidence for previously unknown variability opening a new window into viewing PWNe.
Galactic extinction laws – II. Hidden in plain sight, a new interstellar absorption band at 7700 Å broader than any known DIB
Authors: Maíz Apellániz J , Barbá R H , Caballero J A , Bohlin R C , Fariña C 
Published: August 2020

ABSTRACT
We have detected a broad interstellar absorption band centred close to 7700 Å and with a full width at half-maximum (FWHM) of 176.6 ± 3.9 Å. This is the first such absorption band detected in the optical range and is significantly wider than the numerous diffuse interstellar bands (DIBs). It remained undiscovered until now because it is partially hidden behind the A telluric band produced by O2. The band was discovered using STIS@HST spectra and later detected in a large sample of stars of diverse type (OB stars, BA supergiants, red giants), using further STIS and ground-based spectroscopy. The EW of the band is measured and compared with our extinction and K i λλ7667.021, 7701.093 measurements for the same sample. The carrier is ubiquitous in the diffuse and translucent Galactic interstellar medium (ISM) but is depleted in the environment around OB stars. In particular, it appears to be absent or nearly so in sightlines rich in molecular carbon. This behaviour is similar to that of the σ-type DIBs, which originate in the low/intermediate-density UV-exposed ISM but are depleted in the high-density UV-shielded molecular clouds. We also present an update on our previous work on the relationship between E(4405–5495) and R5495 and incorporate our results into a general model of the ISM.
Star cluster formation in the most extreme environments: insights from the HiPEEC survey
Authors: Adamo A , Hollyhead K , Messa M , Ryon J E , Bajaj V , Runnholm A , Aalto S , Calzetti D , Gallagher J S , Hayes M J , Kruijssen J M D , König S , Larsen S S , Melinder J , Sabbi E , Smith L J , Östlin G 
Published: August 2020

ABSTRACT
We present the Hubble imaging Probe of Extreme Environments and Clusters (HiPEEC) survey. We fit HST NUV to NIR broad-band and H α fluxes to derive star cluster ages, masses, and extinctions and determine the star formation rate (SFR) of six merging galaxies. These systems are excellent laboratories to trace cluster formation under extreme gas physical conditions, rare in the local Universe, but typical for star-forming galaxies at cosmic noon. We detect clusters with ages of 1–500 Myr and masses that exceed 107 M⊙. The recent cluster formation history and their distribution within the host galaxies suggest that systems such as NGC 34, NGC 1614, and NGC 4194 are close to their final coalescing phase, while NGC 3256, NGC 3690, and NGC 6052 are at an earlier/intermediate stage. A Bayesian analysis of the cluster mass function in the age interval 1–100 Myr provides strong evidence in four of the six galaxies that an exponentially truncated power law better describes the observed mass distributions. For two galaxies, the fits are inconclusive due to low number statistics. We determine power-law slopes β ∼ −1.5 to −2.0 and truncation masses, Mc, between 106 and a few times 107 M⊙, among the highest values reported in the literature. Advanced mergers have higher Mc than early/intermediate merger stage galaxies, suggesting rapid changes in the dense gas conditions during the merger. We compare the total stellar mass in clusters to the SFR of the galaxy, finding that these systems are among the most efficient environments to form star clusters in the local Universe.
FASTQINS and ANUBIS: two bioinformatic tools to explore facts and artifacts in transposon sequencing and essentiality studies
Authors: Miravet-Verde Samuel , Burgos Raul , Delgado Javier , Lluch-Senar Maria , Serrano Luis 
Published: August 2020

Abstract
Transposon sequencing is commonly applied for identifying the minimal set of genes required for cellular life; a major challenge in fields such as evolutionary or synthetic biology. However, the scientific community has no standards at the level of processing, treatment, curation and analysis of this kind data. In addition, we lack knowledge about artifactual signals and the requirements a dataset has to satisfy to allow accurate prediction. Here, we have developed FASTQINS, a pipeline for the detection of transposon insertions, and ANUBIS, a library of functions to evaluate and correct deviating factors known and uncharacterized until now. ANUBIS implements previously defined essentiality estimate models in addition to new approaches with advantages like not requiring a training set of genes to predict general essentiality. To highlight the applicability of these tools, and provide a set of recommendations on how to analyze transposon sequencing data, we performed a comprehensive study on artifacts corrections and essentiality estimation at a 1.5-bp resolution, in the genome-reduced bacterium Mycoplasma pneumoniae. We envision FASTQINS and ANUBIS to aid in the analysis of Tn-seq procedures and lead to the development of accurate genome essentiality estimates to guide applications such as designing live vaccines or growth optimization.
Blood Viral Load (VL) Not Clinically Meaningful in Symptomatic Congenital Cytomegalovirus (cCMV) Infection
Authors: Marsico Concetta , Aban Inmaculada , Kuo Huichien , Sanchez Pablo J , Ahmed Amina , Arav-Boger Ravit , Michaels Marian , Ashouri Negar , Englund Janet , Estrada Benjamin , Jacobs Richard , Romero Jose R , Sood Sunil , Whitworth Suzanne , James Scott H , Jester Penny , Whitley Richard , Kimberlin David W ,   Collaborative Antiviral Study Group (CASG)
Published: August 2020

Abstract

Background
Sensorineural hearing loss (SNHL) and neurodevelopmental (ND) outcomes are favorably impacted by antiviral therapy in infants with symptomatic cCMV disease. We correlated blood VL before and during therapy with clinical findings at presentation and follow-up in this population.

Methods
Post-hoc analysis of two clinical trials conducted by the CASG from 2002 to 2013 evaluating valganciclovir therapy. 120 subjects (73 treated × 6 weeks, 47 treated × 6 months) were included. Whole blood VL was determined by real-time PCR at a central laboratory before therapy (baseline, BL) and periodically for 6 months.

Results
In subjects treated for 6 months, increases in BL VL correlated with decreased probability of better hearing outcomes at 12 months (Figure 1), but clinically meaningful VL thresholds that predict SNHL were not identified (Table 1). Subjects treated for 6 weeks had no correlation between BL VL and SNHL. No correlation was found between BL VL and Bayley ND testing at 12 and 24 months for subjects receiving either treatment duration. Subjects treated for 6 months who achieved and sustained VL suppression (&lt;2.5 log) between treatment day 14 and month 4 had better hearing outcomes at 6, 12, and 24 months (89% vs. 56%, P = 0.01; 100% vs. 63%, P = 0.0007; 94% vs. 68%, P = 0.04), but 56%–68% of subjects not achieving suppression still had improved hearing. Higher BL VL correlated with BL CNS involvement, thrombocytopenia, and transaminase elevation for subjects receiving either treatment duration, but with substantial overlap in quantity of virus detected (Figure 2). Subjects with &gt;3 symptoms of congenital CMV at presentation had higher BL VL than subjects with ≤3 symptoms (3.75 log, range 1.00–5.65, vs. 3.38 log, range 1.00–5.36; P = 0.005).

Conclusion
Blood VL at BL and during therapy has little clinically meaningful predictive value for long-term outcomes in symptomatic congenital CMV.

Disclosures
J. Englund, Gilead: Consultant and Investigator, Research support; Chimerix: Investigator, Research support; Alios: Investigator, Research support; Novavax: Investigator, Research support; MedImmune: Investigator, Research support; GlaxoSmithKline: Investigator, Research support