bluuebunny/crossref_metadata_2025_split huggingface dataset:
Koori voices: self-harm, suicide attempts, arrests and substance use among Aboriginal and Torres Strait Islander adolescents following residential treatment
Authors: Nathan S. , Maru K. , Williams M. , Palmer K. , Rawstorne P. 
Published: February 2020

Abstract
Background
Complex interacting social, economic and historical factors influence the availability and uptake of alcohol and drugs, including among Indigenous communities. Self-harm and suicide as well as homelessness and incarceration, can both precede and result from drug and alcohol use. Rates of self-harm, suicide and incarceration among Aboriginal and Torres Strait Islander people in Australia are among the highest in the world and drug and alcohol treatment programs need to address these underlying complexities. This study examines whether an ‘holistic’ residential drug and alcohol treatment program for adolescents, with over 30% of clients identifying as Aboriginal and Torres Strait Islander, can improve outcomes post-discharge, including reducing self-harm, suicide attempts, arrests and alcohol and drug use. The program addresses substance use, mental health, employment, accommodation, social/community and family life. Program admission and 3 months’ post-discharge data from 2007 to 2016 were analysed.

Results
From 2007 to 2016, 619 Aboriginal and Torres Strait Islander young people were admitted to the program; 247 stayed in the program for 30 days or more; 89 were successfully followed up three months post-discharge to determine whether there was a significant improvement from baseline using the McNemar’s Test and the Wilcoxon Signed Ranks Test. On admission, 18 people (20%) of the study population reported attempting suicide in the last 3 months and 23 people (30%) reported self-harm. Most had been engaged in the criminal justice system, with 67 people (75%) having been to court and 62 people (70%) arrested one or more times in the past 3 months, with 35 people (41%) in unstable housing, reporting having lived in three or more places in the previous 6 months. At 3 months post-treatment, all (n = 18) who reported suicide attempts in the 3 months prior to admission reported no attempts in the prior 3 months at follow-up. There was also a significant reduction in self-harm with 23 young people out of the 27 who reported self-harm at baseline not reporting self-harm at follow up (85%) and in the proportion of adolescents who reported using cannabis, amphetamines and alcohol, as well as a reduction in the proportion who reported being arrested.

Conclusions
The findings provide support for an ‘holistic’ residential treatment program as an approach to improve health and related outcomes for Aboriginal and Torres Strait Islander young people. In addition to a focus on multiple aspects of a young person’s life in treatment, culturally relevant modes of treatment and support should be a future focus to further strengthen programs when Aboriginal and Torres Strait Islander young people are over-represented in the client group.
The relationship between personality traits and marital satisfaction: a systematic review and meta-analysis
Authors: Sayehmiri Kourosh , Kareem Karez Ibrahim , Abdi Kamel , Dalvand Sahar , Gheshlagh Reza Ghanei 
Published: February 2020

AbstractBackgroundPersonality traits can be used to predict an individual’s behaviors in different life situations, including marital life situations. Marital satisfaction that is influenced by different factors is a criterion used to assess couples’ relationship quality. The goal of the present study was to review Iranian studies on the correlation between personality traits and marital satisfaction.MethodsIn this systematic review, all the related Iranian studies in international databases, including Google Scholar, PubMed, Web of Science (ISI) and Scopus, and national databases, including Scientific Information Database (SID) and MagIran were reviewed. The following keywords and also combinations of them were used to search the databases: “Marital satisfaction,” “Personality traits,” “Personality factors,” “Big five model of personality,” and “Iran.”ResultsA total of 18 correlational studies, without any time limitation, with a total sample of 4049, were reviewed. The following correlation coefficients were found between marital satisfaction and personality traits: r = − 0.439 with neuroticism (95% Confidence Interval [CI]: 0.27–0.60), r = 0.833 with extraversion (95% CI: 0.77–0.88), r = 0.777 with openness (95% CI: 0.70–0.84), r = 0.855 with agreeableness (95% CI: 0.80–0.90), and r = 0.90 with conscientiousness (95% CI: 0.84–0.95).ConclusionsCouples high in Neuroticism experience lower levels of marital satisfaction, and couples high in Conscientiousness are more satisfied with their marital life.
Evaluation of antioxidant, anti-hemolytic, cytotoxic effects and anti-bacterial activity of selected mangrove plants (Bruguiera gymnorrhiza and Heritiera littoralis) in Bangladesh
Authors: Karim Md. Adnan , Islam Md. Aminul , Islam Md. Muzahidul , Rahman Md. Saidur , Sultana Sharmin , Biswas Satyajit , Hosen Mohammad Jakir , Mazumder Kishor , Rahman Md. Masuder , Hasan Md. Nazmul 
Published: February 2020

AbstractObjectivesIn this present study, antioxidant, anti-hemolytic, cytotoxic and anti-bacterial activities derived from methanol extracts ofBruguiera gymnorrhizaandHeritiera littoraliswere investigated in order to determine their medicinal activities.Materials and methodsFolin-Ciocalteu reagent method and aluminum chloride methods were used to determine the mangroves’ total phenolics and total flavonoid content, respectively. Antioxidant capacity was assessed via the following methods: 1,1-diphenyl-2-picryl hydroxyl (DPPH), 43 mM H2O2, Fe2+quenching assay, and anti-hemolytic activity. Brine shrimp (Artemia salinaL.) lethality assay was also carried out to determine the cytotoxic potential of the mangroves along with anti-bacterial activity test using five Gram-negative and another two Gram-positive bacterial strains.ResultsThe mangroves yielded 58.917 ± 0.601 and 36.625 ± 0.551 mg Gallic acid equivalent (GAE)/g sample and 76.417 ± 0.19 and 113.637 ± 0.17 mg quercetin equivalent (QE)/g sample inB. gymnorrhizaandH. littoralis, respectively. Methanol extracts of both mangroves exhibited high radical scavenging activity against DPPH, H2O2and Fe2+radicals. The reductive capacity of the extracts increased with increasing concentrations of samples, and the extracts inhibited H2O2induced hemolysis in human red blood cells (RBCs). Antioxidant properties were found to be moderately weaker than that of the reference standard, L-ascorbic acid (AA), and Gallic acid (GA). Further, brine shrimp (Artemia salinaL.) lethality assay revealed significant cytotoxicity (241.4 and 272.6 μg/mL, respectively). Methanol extracts could also inhibit the growth of pathogenic bacterial strains.ConclusionThis study showed that the crude methanol extract of selected mangrove plants possesses free radical scavenging, anti-hemolytic, cytotoxic and anti-bacterial activity. The experimented plant has the potential to be used as a traditional medicine and replace synthetic drugs. Further studies are necessary to isolate active compounds responsible for the overall antioxidant activity of the crude extracts.
Outcome of transforaminal epidural steroid injection for lumbar radiculopathy: initial three-year experience at Upendra Devkota Memorial-National Institute of Neurological and Allied Sciences, Nepal
Authors: Shrestha Pratyush , Subba Lojima , Agrawal Prity , Lohani Subash 
Published: February 2020

AbstractBackgroundThe prevalence of low back pain with radiculopathy in general population varies from 9.9% to 25%, which can be due to bony narrowing of the lateral recess or due to prolapsed intervertebral disc. Transforaminal epidural injection of a mixture of long-acting anaesthetic (bupivacaine) and particulate steroids (depomedrol) has been a treatment modality in patients not responding to initial physiotherapy and neuropathic pain medications.MethodsTo analyze the effectiveness of transforaminal epidural steroid injection (TFESI) in the treatment of low back pain with radiculopathy, a retrospective case series evaluating the records of patients that received TFESI (1 mL 0.5% bupivacaine +1 ml/40 mg depomedrol) under C-arm guidance from January 2015 to December 2018 (3 years) at Upendra Devkota Memorial-National Institute of Neurological and Allied Sciences (UDM-NINAS), their lumbo-sacral MRI and the pre-procedure, 1-week and 3-month numeric pain rating scale, were analyzed. Successful treatment (reduction of pain scale by more than 50% of baseline at 3 months) in the patients with bony recess stenosis and those with prolapsed intervertebral disc was compared.ResultsOut of 67 patients that received TFESI, 35 (52.23%) could be followed up. The mean age was 55.8 ± 14.39 years and 51.3% were females. 68.57% had L5 and 20% had S1 radiculopathy. Bony recess stenosis was seen in the aged 40% and PIVD was the cause of radiculopathy in 60%. The median duration of radicular pain prior to intervention was 3 months. TFESI was effective as the mean numeric pain scale before injection was 8.97 ± 1.32 which reduced to 3.91 ± 3.23 (pairedttestpvalue < 0.001) at 1 week post injection and 3.23 ± 3.34 (pairedttestpvalue < 0.001) at 3 months post injection. Twenty-six of the 35 patients (75.29%) had more than 50% pain relief compared to baseline at 3 months and were satisfied. Nine patients continued to have pain; however, only one required a surgical intervention. The effectiveness of TFESI was not significantly different in different ages (Fisher’s exact testpvalue 0.182) and in different anatomic levels (Fisher’s exact testpvalue 0.241). Six out of eight patients with bony recess stenosis benefited as compared to 14 out of 19 patients with PIVD, though it was not statistically significant (Fischer’s exact testpvalue 0.688). There were no adverse events recorded.ConclusionTFESI is a safe and efficacious treatment modality in patients with radicular low back pain especially in aged patients in whom surgery under general anaesthesia is not free from risk.
Locally advanced rectal cancer: 3D diffusion-prepared stimulated-echo turbo spin-echo versus 2D diffusion-weighted echo-planar imaging
Authors: Zhang Qinwei , van Houdt Petra J. , Lambregts Doenja M. J. , van Triest Baukelien , Kop Marnix P. M. , Coolen Bram F. , Strijkers Gustav J. , van der Heide Uulke A. , Nederveen Aart J. 
Published: February 2020

Abstract
Background
Diffusion-weighted imaging (DWI) has shown great value in rectal cancer imaging. However, traditional DWI with echo-planar imaging (DW-EPI) often suffers from geometrical distortions. We applied a three-dimensional diffusion-prepared stimulated-echo turbo spin-echo sequence (DPsti-TSE), allowing geometrically undistorted rectal DWI. We compared DPsti-TSE with DW-EPI for locally advanced rectal cancer DWI.

Methods
For 33 prior-to-treatment patients, DWI images of the rectum were acquired with DPsti-TSE and DW-EPI at 3 T using b-values of 200 and 1000 s/mm2. Two radiologists conducted a blinded scoring of the images considering nine aspects of image quality and anatomical quality. Tumour apparent diffusion coefficient (ADC) and distortions were compared quantitatively.

Results
DPsti-TSE scored significantly better than DW-EPI in rectum distortion (p = 0.005) and signal pileup (p = 0.001). DPsti-TSE had better tumour Dice similarity coefficient compared to DW-EPI (0.84 versus 0.80, p = 0.010). Tumour ADC values were higher for DPsti-TSE compared to DW-EPI (1.47 versus 0.86 × 10-3 mm2/s, p < 0.001). Radiologists scored DPsti-TSE significantly lower than DW-EPI on aspects of overall image quality (p = 0.001), sharpness (p < 0.001), quality of fat suppression (p < 0.001), tumour visibility (p = 0.009), tumour conspicuity (p = 0.010) and rectum wall visibility (p = 0.005).

Conclusions
DPsti-TSE provided geometrically less distorted rectal cancer diffusion-weighted images. However, the image quality of DW-EPI over DPsti-TSE was referred on the basis of several image quality criteria. A significant bias in tumour ADC values from DPsti-TSE was present. Further improvements of DPsti-TSE are needed until it can replace DW-EPI.
Integrating radiomics into holomics for personalised oncology: from algorithms to bedside
Authors: Gatta Roberto , Depeursinge Adrien , Ratib Osman , Michielin Olivier , Leimgruber Antoine 
Published: February 2020

AbstractRadiomics, artificial intelligence, and deep learning figure amongst recent buzzwords in current medical imaging research and technological development. Analysis of medical big data in assessment and follow-up of personalised treatments has also become a major research topic in the area of precision medicine. In this review, current research trends in radiomics are analysed, from handcrafted radiomics feature extraction and statistical analysis to deep learning. Radiomics algorithms now include genomics and immunomics data to improve patient stratification and prediction of treatment response. Several applications have already shown conclusive results demonstrating the potential of including other “omics” data to existing imaging features. We also discuss further challenges of data harmonisation and management infrastructure to shed a light on the much-needed integration of radiomics and all other “omics” into clinical workflows. In particular, we point to the emerging paradigm shift in the implementation of big data infrastructures to facilitate databanks growth, data extraction and the development of expert software tools. Secured access, sharing, and integration of all health data, called “holomics”, will accelerate the revolution of personalised medicine and oncology as well as expand the role of imaging specialists.
Black esophagus as an autopsy discovery: a challenging interpretation
Authors: Kerschen Anja , Schmit Gregory , De Boosere Evy , Palmiere Cristian , Vanhaebost Jessica 
Published: February 2020

AbstractBlack esophagus is a rare medical condition, characterized by a circumferential blackish discoloration of the distal part of the esophageal mucosa, abruptly ending at the gastroesophageal junction. The etiology is multifactorial since patients suffer from multiple comorbidities. While the mortality rate specifically linked to black esophagus is only around 6%, the mortality rate linked to the underlying comorbidities amounts to 32%.A series of five cases is provided in which black esophagus was an unexpected discovery at autopsy. Black esophagus is generally considered being a challenge to the forensic pathologist. There are often no other major gross anomalies found at autopsy and information about the patient’s medical history is not always available, which complicates a correct assessment.We present a review of the literature on black esophagus, limited to reports on deceased patients. The reviewed publications are divided into autopsy and endoscopy series to correctly compare the causes of death.The aim of this review is to identify a possible divergence in causes of death in autopsy and endoscopy series and additionally to analyze the causes of these differences to enable better assessment and interpretation of black esophagus at forensic autopsies. This paper emphasizes the importance of a minimal knowledge of the victim’s comorbidities and medical record and the use of toxicology and postmortem biochemistry analysis as a valuable tool in investigating the cause of death in the setting of black esophagus.
The applicability of Willems dental age estimation method for Indonesian children population in Surabaya
Authors: Kurniawan Arofi , Agitha Shintya Rizky Ayu , Margaretha Mieke Sylvia , Utomo Haryono , Chusida An’nisaa , Sosiawan Agung , Marini Maria Istiqomah , Rizky Beta Novia 
Published: February 2020

Abstract
Background
The applicability of dental age estimation has been expanded to meet a variety of medico-legal needs, law enforcement, and disaster victim identification. The objective of this study is to examine the applicability of the Willems method for Indonesian children.

Material and method
A total of 110 panoramic radiographs of the patients (6–14 years old) who met the inclusion criteria were obtained from the Department of Forensic Odontology and Department of Radiology, Universitas Airlangga, Indonesia. Estimated dental age (EDA) was assessed using the Willems method by two blinded examiners. The statistical analysis was carried out using IBM® SPSS® Statistics version 23.0 (IBM, Armonk, NY, USA).

Results and discussion
The mean of the chronological age (CA) in this study is 11.30 ± 1.43 years (boys) and 11.65 ± 1.55 years (girls). The overall mean difference between CA and EDA for boys and girls is − 0.08 ± 0.76 and − 0.31 ± 0.97, respectively. This study showed that the mean age difference in girls was more significant than in boys. The growth spurt timing between boys and girls might cause a difference in dental maturation, whereas the onset of the pubertal growth spurt in girls is about 2 years earlier than in boys. In general, girls start and finish their dental development earlier than boys end.

Conclusion
The present study suggests that the dental age estimation methods proposed by Willems can be considered as an applicable method for the children population in Surabaya, both boys and girls. However, a detailed study may be required while applying this approach to the 11–14-year-old girl population in Surabaya, as a substantial underestimation was observed in this community.
Antibiotic resistance gene sharing networks and the effect of dietary nutritional content on the canine and feline gut resistome
Authors: Kim Younjung , Leung Marcus H. Y. , Kwok Wendy , Fournié Guillaume , Li Jun , Lee Patrick K. H. , Pfeiffer Dirk U. 
Published: February 2020

AbstractBackgroundAs one of the most densely populated microbial communities on Earth, the gut microbiota serves as an important reservoir of antibiotic resistance genes (ARGs), referred to as the gut resistome. Here, we investigated the association of dietary nutritional content with gut ARG diversity and composition, using publicly available shotgun metagenomic sequence data generated from canine and feline fecal samples. Also, based on network theory, we explored ARG-sharing patterns between gut bacterial genera by identifying the linkage structure between metagenomic assemblies and their functional genes obtained from the same data.ResultsIn both canine and feline gut microbiota, an increase in protein and a reduction in carbohydrate in the diet were associated with increased ARG diversity. ARG diversity of the canine gut microbiota also increased, but less strongly, after a reduction in protein and an increase in carbohydrate in the diet. The association between ARG and taxonomic composition suggests that diet-induced changes in the gut microbiota may be responsible for changes in ARG composition, supporting the links between protein metabolism and antibiotic resistance in gut microbes. In the analysis of the ARG-sharing patterns, 22 ARGs were shared among 46 genera in the canine gut microbiota, and 11 ARGs among 28 genera in the feline gut microbiota. Of these ARGs, the tetracycline resistance genetet(W) was shared among the largest number of genera, predominantly amongFirmicutesgenera.Bifidobacterium, a genus extensively used in the fermentation of dairy products and as probiotics, sharedtet(W) with a wide variety of other genera. Finally, genera from the same phylum were more likely to share ARGs than with those from different phyla.ConclusionsOur findings show that dietary nutritional content, especially protein content, is associated with the gut resistome and suggest future research to explore the impact of dietary intervention on the development of antibiotic resistance in clinically-relevant gut microbes. Our network analysis also reveals that the genetic composition of bacteria acts as an important barrier to the horizontal transfer of ARGs. By capturing the underlying gene-sharing relationships between different bacterial taxa from metagenomes, our network approach improves our understanding of horizontal gene transfer dynamics.
Gastronomic satisfaction of the tourist: empirical study in the Creative City of Popayán, Colombia
Authors: Rodríguez-Gutiérrez Pablo , González Santa Cruz Francisco , Pemberthy Gallo Luz Stella , López-Guzmán Tomás 
Published: February 2020

AbstractCurrently, gastronomy is a fundamental element for tourists to discover the culture and traditions of a destination. The transcendence granted to a culinary experience in a specific place can become a fundamental motivation for the visit and determine the level of satisfaction reached. In this research, the relationship between tourism and gastronomy is analysed in the city of Popayán, Colombia, a city that has received recognition from UNESCO as a Creative City of Gastronomy. To do this, we examine the influence of different dimensions of culinary motivation in the satisfaction with gastronomy that is experienced during the visit. In addition, we analyse the role of tourist attitude towards culinary experience in gastronomy satisfaction. The methodology used in this research is based on partial least squares structural equation modelling. The main results indicate that the importance of the culinary experience of the tourist in the choice of the destination mediates the effect that culinary motivations exercise on the satisfaction with the gastronomy.
Diagnosis of gastric cancer by MDCT gastrography: diagnostic characteristics and management potential
Authors: Zytoon Ashraf Anas , El-Atfey Safaa Ibrahim Bendary , Hassanein Shaimaa Abdel-Hamid 
Published: February 2020

Abstract
Background
Gastric cancer is regarded as the fifth most frequent tumor globally but the third most common fatal illness. As early as possible, we diagnose cancer stomach especially at early stages, the higher the rate of life. Nevertheless, most cases are diagnosed at late cases where surgery is not of the same benefit at early stages because of clinically indefinite symptoms. The prospective study goal is to estimate the role of MDCT in diagnosis and staging of cancer stomach.

Results
In our study, it was found that there was a high relationship between pathological and CT staging by using MPR. CT with MPR was specific and accurate in diagnosis of all stages of gastric cancer with specificity ranged between 93 and 97% and accuracy ranged between 90 and 92.5%. However, it showed lowest sensitivity in diagnosis of stage 1 of gastric cancer. On the other hand, it showed highest sensitivity (90%) in diagnosis of stage IV as well as we found that MPR and VR of MDCT are much more accurate (92.5%) than multi-detector computed tomography axial images (80%) in the diagnosis of all stages of gastric cancer with the difference between the two sequences was significant (P = 0.009).

Conclusion
Our results demonstrate that preoperative MDCT with contrast filling technique for abdomen and pelvis evaluates the local disease process of gastric cancer as well as the potential areas of spread. This information is vital in choosing between palliative or radical surgery. MPR and VR help in the assessment of tumor extension and considered as a highly representative prognostic value. Making it the imaging modality of choice in diagnosis and staging of gastric cancers.