bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influenza vaccination in breast cancer patients during subcutaneous trastuzumab in adjuvant setting
Authors: Joona Therse Björkin , Digkas Evangelos , Wennstig Anna-Karin , Nyström Karin , Nearchou Andreas , Nilsson Cecilia , Pauksens Karlis , Valachis Antonis 
Published: August 2020

Abstract
Background
Despite the current recommendation for influenza vaccination in cancer patients with active oncological therapy, limited data are available on the efficacy of vaccination in cancer patients receiving targeted therapies. We aimed to investigate the immunogenicity and tolerability of influenza vaccination in breast cancer patients treated with trastuzumab in adjuvant setting.

Methods
A prospective open-label multicenter study was performed including patients with breast cancer during trastuzumab treatment in adjuvant setting and healthy controls. Blood samples were taken before, 4 weeks after, and 12 weeks after a single dose of trivalent influenza vaccine containing inactivated A/California/7/2009 (H1N1) pdm09, A/Hongkong4801/2014 (H3N2), and B/Brisbane/60/2008. Levels of serum antibody titers to hemagglutinin for H1N1 and influenza B strains were measured.

Results
Twenty breast cancer patients and 37 controls were included in the study. No difference in seroprotection rate between trastuzumab-treated patients and controls was observed for either H1N1 (100% in both groups) or B strain (78.9% vs. 89.2%, p value = 0.423). A statistically significant increase in geometric mean titers from baseline was seen in both groups and was evident both 4 weeks and 12 weeks after vaccination. Adverse events in the trastuzumab-treated group were uncommon and mild with only one serious adverse event not related to vaccination.

Conclusion
Breast cancer patients treated with trastuzumab in adjuvant setting seem to benefit from influenza vaccination in terms of immunogenicity without increasing the risk for adverse events. The current data support the recommendation to offer influenza vaccination in breast cancer patients treated with this type of targeted therapy.
Previously diagnosed multiple primary malignancies in patients with breast carcinoma in Western Sweden between 2007 and 2018
Authors: Nyqvist Jenny , Parris Toshima Z. , Helou Khalil , Sarenmalm Elisabeth Kenne , Einbeigi Zakaria , Karlsson Per , Nasic Salmir , Kovács Anikó 
Published: August 2020

Abstract
Purpose
Multiple primary malignancies (MPMs) caused by breast cancer treatment are well described, but only few studies to date describe which other previous primary malignancies (OPPMs) occur before breast cancer. The purpose of the present study was to evaluate the prevalence of OPPMs in patients with breast cancer between 2007 and 2018 in Western Sweden.

Methods
Patient selection was performed using both pathology reports at Sahlgrenska University Hospital (Sweden) and the Swedish Cancer Registry. All newly diagnosed breast cancer patients were screened for presence of OPPM.

Results
In total, 8031 breast cancer patients were diagnosed at Sahlgrenska University Hospital between 2007 and 2018. The prevalence of breast cancer patients with OPPMs (n = 414) increased from on average 2.6% to 8.2% during this 12-year period and ranged from 17 to 59 patients annually. The most striking increase in prevalence was found among the gynecological tumors (endometrium and ovarian adenocarcinomas), malignant melanomas and gastrointestinal malignancies. These findings were validated using data of the Swedish Cancer Registry.

Conclusions
The overall survival rates for cancer patients have improved tremendously during the past 40 years, in part due to individually tailored therapies and screening programs. Our study revealed an increasing trend of OPPMs in breast cancer patients.
The Systemic Assessment Clinic, a Novel Method for Assessing Patients in General Adult Psychiatry: Presentation and Preliminary Service Evaluation
Authors: Turri Maria Grazia , Merson Stephen , McNab Sue , Cooper Ruth E. 
Published: August 2020

AbstractThe traditional model of psychiatric assessment and diagnosis can be criticised as reductive. We developed an innovative model for psychiatric assessment of adult patients referred to our adult mental health team, the Systemic Assessment Clinic, incorporating the principles and techniques of systemic family therapy and dialogical practice into standard psychiatric assessment. We conducted a service evaluation, comparing prospective use of mental health services for patients assessed either in the Systemic Assessment Clinic or in standard assessment. Patients assessed in the Systemic Assessment Clinic had more favourable outcomes than those in standard assessment: they were significantly less likely to need multiple follow-up treatment appointments with a psychiatrist and to be re-referred to mental health services once discharged, indicating reduced healthcare costs. Satisfaction rates for participants attending the systemic assessment clinic were high. Our service evaluation gives preliminary evidence that the Systemic Assessment Clinic could be a potential new model for psychiatric assessment; further evaluation is warranted in a randomised controlled trial.
Looking at Mental Effort Appraisals through a Metacognitive Lens: Are they Biased?
Authors: Scheiter Katharina , Ackerman Rakefet , Hoogerheide Vincent 
Published: August 2020

AbstractA central factor in research guided by the Cognitive Load Theory (CLT) is the mental effort people invest in performing a task. Mental effort is commonly assessed by asking people to report their effort throughout performing, learning, or problem-solving tasks. Although this measurement is considered reliable and valid in CLT research, metacognitive research provides robust evidence that self-appraisals of performance are often biased. In this review, we consider the possibility that mental effort appraisals may also be biased. In particular, we review signs for covariations and mismatches between subjective and objective measures of effort. Our review suggests that subjective and most objective effort measures appear reliable and valid when evaluated in isolation, because they discriminate among tasks of varying complexity. However, not much is known about their mutual correspondence—that is, whether subjective measures covariate with objective measures. Moreover, there is evidence that people utilize heuristic cues when appraising their effort, similar to utilization of heuristic cues underlying metacognitive appraisals of performance. These cues are identified by exposing biases—mismatch in effects of cue variations on appraisals and performance. The review concludes with a research agenda in which we suggest applying the well-established methodologies for studying biases in self-appraisals of performance in metacognitive research to investigating effort appraisals. One promising method could be to determine the covariation of effort appraisals and objective effort measures as an indicator of the resolution of effort appraisals.
Interaction between Fusarium oxysporum f. sp. cubense and Radopholus similis can lead to changes in the resistance of banana cultivars to Fusarium wilt
Authors: Rocha Anelita de Jesus , Ferreira Mileide dos Santos , Rocha Leandro de Souza , Oliveira Saulo A. S. , Amorim Edson Perito , Mizubuti Eduardo S. G. , Haddad Fernando 
Published: August 2020

AbstractFusarium oxysporum f. sp. cubense (Foc) causes Panama disease or Fusarium wilt of bananas. The association between soil-inhabiting fungi and nematodes can increase the severity of symptoms and suppress the resistance of plants to diseases. In this study, the interaction between Foc race 1 and Radopholus similis, a burrowing nematode that parasitizes banana plants, was analyzed using one moderately susceptible cultivar and seven resistant cultivars of banana. Two Foc isolates that differed in virulence were tested. The analyses of symptoms and stained fungal structures in the roots demonstrated that R. similis interacting with Foc in different inoculation sequences caused changes in symptom severity and the resistance pattern to Foc isolate 0801 (race 1) in cultivars ‘Terra Maranhão’, ‘BRS Pacovan Ken’, ‘BRS Vitória’, and ‘BRS Platina’. The data generated in this study have relevant implications for banana breeding programs in the classification of cultivars for durable resistance to Fusarium wilt and for understanding pathogen interactions during occurrence of the disease.
Integrated Care Systems as an Arena for the Emergence of New Forms of Epistemic Injustice
Authors: Fletcher Andrew , Clarke Jeremy 
Published: August 2020

AbstractEpistemic injustice has rapidly become a powerful tool for analysis of otherwise hidden social harms. Yet empirical research into how resistance to knowing and understanding can be generated and replicated in social programmes is limited. We have identified a range of subtle and not-so-subtle inflections of epistemic injustice as they play out in an intervention for people with chronic depression in receipt of disability benefits. This article describes the different ‘species’ of epistemic injustice observed and reveals how these are unintentionally produced at frontline, management, commissioning and policy levels. Most notably, there remains a privileging of clinical knowledge over other forms of knowledge, producing a ‘pathocentric epistemic complex’. This, combined with the failure of different agencies with competing ideologies to adequately understand each other, and a vicious policy context, added to the injustices already faced by people with mental health issues, generating multiple harms. This has important implications for a range of integrated care and welfare interventions – not least by drawing attention to their unintended potential for replicating epistemic injustice as an institutionalised complex. Careful evaluation and design of such programmes, applying the philosophical and epistemic resources illustrated here, can help mitigate this outcome. Further, by raising awareness of epistemic injustice among programme participants, we can generate epistemic structures that secure programme integrity locally, and promote better policy.
Ocular sarcoidosis: clinical experience and recent pathogenetic and therapeutic advancements
Authors: Dammacco Rosanna , Biswas Jyotirmay , Kivelä Tero T. , Zito Francesco Alfredo , Leone Patrizia , Mavilio Alberto , Sisto Dario , Alessio Giovanni , Dammacco Franco 
Published: August 2020

Abstract
Purpose
To describe the ocular manifestations in a cohort of patients with systemic sarcoidosis (SS). Recent advances in the pathophysiology, diagnosis, and therapy of SS are also discussed.

Methods
Data from 115 Italian patients diagnosed between 2005 and 2016 were retrospectively reviewed. All but the first 17 patients underwent a comprehensive ophthalmologic examination. The diagnosis was based on clinical features, the demonstration of non-caseating granulomas in biopsies from involved organs, and multiple imaging techniques. Data on broncho-alveolar lavage fluid analysis, calcemia, calciuria, serum angiotensin-converting enzyme levels and soluble interleukin-2 receptor levels were retrieved when available.

Results
Ocular involvement, detected in 33 patients (28.7%), was bilateral in 29 (87.9%) and the presenting feature in 13 (39.4%). Anterior uveitis was diagnosed in 12 patients (36.4%), Löfgren syndrome and uveoparotid fever in one patient each (3%), intermediate uveitis in 3 patients (9.1%), posterior uveitis in 7 (21.2%), and panuveitis in 9 (27.3%). First-line therapy consisted of corticosteroids, administered as eyedrops (10 patients), sub-Tenon’s injections (1 patient), intravitreal implants (9 patients), or systemically (23 patients). Second-line therapy consisted of steroid-sparing immunosuppressants, including methotrexate (10 patients) and azathioprine (10 patients). Based on pathogenetic indications that tumor necrosis factor (TNF)-α is a central mediator of granuloma formation, adalimumab, targeting TNF-α, was employed in 6 patients as a third-line agent for severe/refractory chronic sarcoidosis.

Conclusion
Uveitis of protean type, onset, duration, and course remains the most frequent ocular manifestation of SS. Diagnostic and therapeutic advancements have remarkably improved the overall visual prognosis. An ophthalmologist should be a constant component in the multidisciplinary approach to the treatment of this often challenging but intriguing disease.
Links Between Autistic Traits, Feelings of Gender Dysphoria, and Mentalising Ability: Replication and Extension of Previous Findings from the General Population
Authors: Kallitsounaki Aimilia , Williams David M. , Lind Sophie E. 
Published: August 2020

AbstractGender nonconformity is substantially elevated in the autistic population, but the reasons for this are currently unclear. In a recent study, Kallitsounaki and Williams (Kallitsounaki and Williams, Journal of Autism and Developmental Disorders, 2020; authors 1 and 2 of the current paper) found significant relations between autistic traits and both gender dysphoric feelings and recalled cross-gender behaviour, and between mentalising ability and gender dysphoric feelings. The current study successfully replicated these findings (results were supplemented with Bayesian analyses), in sample of 126 adults. Furthermore, it extended the previous finding of the role of mentalising in the relation between autistic traits and gender dysphoric feelings, by showing that mentalising fully mediated this link. Results provide a potential partial explanation for the increased rate of gender nonconformity in the autistic population.
Creating capacity for learning: Are we there yet?
Authors: Stoll Louise 
Published: August 2020

AbstractOver the years, I’ve been investigating capacity for learning to understand under what conditions it’s seeded, flourishes and is sustainable. Drawing on my own and others’ research and knowledge, I’ve supported school and system leaders internationally in endeavours to create and sustain capacity for learning. My sense is that everyone engaged in similar activity believes that we want the best learning opportunities and outcomes for every child. But, to use a journey metaphor, have we arrived? In this article, I reflect on where we are now, then consider the purpose of learning, who should learn and what kind of learning is needed. I suggest what a system might look like if creating capacity for learning becomes a reality and how we might get there. In conclusion I argue for reorienting the continuing journey.
Pathways from Child Sexual and Physical Abuse to Sexual and Physical Intimate Partner Violence Victimization through Attitudes toward Intimate Partner Violence
Authors: Schuster Isabell , Tomaszewska Paulina 
Published: August 2020

AbstractAlthough many studies have shown that victims of child abuse have an increased vulnerability to revictimization in intimate relationships, the underlying mechanisms are not yet sufficiently well understood. Therefore, this study aimed at examining this relationship for both sexual and physical forms of violence as well as investigating the potential mediating role of attitudes toward sexual and physical intimate partner violence (IPV). Also, the potential moderating role of gender was explored. Sexual and physical child abuse and IPV victimization in adulthood as well as attitudes toward the respective form of IPV were assessed among 716 participants (448 female) in an online survey. The path analyses showed that child sexual abuse was positively linked to sexual IPV victimization among both women and men, whereas child physical abuse was positively associated with physical IPV victimization among women only. Furthermore, the relationship between both forms of child abuse and IPV victimization was mediated through more supportive attitudes toward the respective forms of IPV, but only among men. This study provides novel insights regarding the links between sexual and physical child abuse and revictimization in adulthood, suggesting that supporting attitudes toward IPV may be seen as vulnerability factor for revictimization. The moderating role of gender is especially discussed.
The Influence of Wire Bending and Wire Diameter on Transport Critical Current Density in Small MgB2 Superconducting Coils for Applications in Multi-Section Coils
Authors: Gajda D. , Zaleski A. J. , Morawski A. , Cetner T. , Rindfleisch M. 
Published: August 2020

AbstractThis article presents the impact of MgB2 wire bending and diameter on transport critical current density and irreversible magnetic field of a resultant coil. Unreacted MgB2 wires 500 mm in length and 0.63 or 0.83 mm in diameter have been used in the fabrication of small diameter (14 mm) superconducting coils. The coils were subsequently annealed under isostatic pressure of 1 GPa for 15 min at 700 °C and 725 °C. Our results indicate that larger wire diameter, higher annealing temperature, and bending lead to slight reduction of critical current density and irreversible magnetic field in the coil.
Mitochondrial genome variation in male LHON patients with the m.11778G > A mutation
Authors: Piotrowska-Nowak Agnieszka , Krawczyński Maciej R. , Kosior-Jarecka Ewa , Ambroziak Anna M. , Korwin Magdalena , Ołdak Monika , Tońska Katarzyna , Bartnik Ewa 
Published: August 2020

AbstractLeber hereditary optic neuropathy (LHON) is a mitochondrial disorder with symptoms limited to a single tissue, optic nerve, resulting in vision loss. In the majority of cases it is caused by one of three point mutations in mitochondrial DNA (mtDNA) but their presence is not sufficient for disease development, since ~50% of men and ~10% women who carry them are affected. Thus additional modifying factors must exist. In this study, we use next generation sequencing to investigate the role of whole mtDNA variation in male Polish patients with LHON and m.11778G > A, the most frequent LHON mutation. We present a possible association between mtDNA haplogroup K and variants in its background, a combination of m.3480A > G, m.9055G > A, m.11299 T > C and m.14167C > T, and LHON mutation. These variants may have a negative effect on m.11778G > A increasing its penetrance and the risk of LHON in the Polish population. Surprisingly, we did not observe associations previously reported for m.11778G > A and LHON in European populations, particularly for haplogroup J as a risk factor, implying that mtDNA variation is much more complex. Our results indicate possible contribution of novel combination of mtDNA genetic factors to the LHON phenotype.
PLC based fractional-order PID temperature control in pipeline: design procedure and experimental evaluation
Authors: Możaryn Jakub , Petryszyn Jakub , Ozana Stepan 
Published: August 2020

AbstractFractional-order control system design can be used for systems with non-local dynamics involving long-term memory effects. However, implementation of a fractional-order controller in industrial systems is complicated, because of the excessive demand for computational power. The following paper presents the step-by-step design procedure, parameter tuning, and experimental evaluation of the fractional order proportional-integral-derivative (FOPID) controller. The control algorithm is based on the Continued Fraction Expansion approximation of the fractional-order operators. It is implemented on a standard industrial Programmable Logic Controller.
The FOPID control system is verified and evaluated in terms of efficiency and robustness using a new laboratory benchmark of a temperature control in the pipeline. The proposed solution shows increased efficiency in terms of robustness compared to the standard PID closed-loop control.
BayesProject: Fast computation of a projection direction for multivariate changepoint detection
Authors: Hahn Georg , Fearnhead Paul , Eckley Idris A. 
Published: August 2020

AbstractThis article focuses on the challenging problem of efficiently detecting changes in mean within multivariate data sequences. Multivariate changepoints can be detected by projecting a multivariate series to a univariate one using a suitable projection direction that preserves a maximal proportion of signal information. However, for some existing approaches the computation of such a projection direction can scale unfavourably with the number of series and might rely on additional assumptions on the data sequences, thus limiting their generality. We introduce BayesProject, a computationally inexpensive Bayesian approach to compute a projection direction in such a setting. The proposed approach allows the incorporation of prior knowledge of the changepoint scenario, when such information is available, which can help to increase the accuracy of the method. A simulation study shows that BayesProject is robust, yields projections close to the oracle projection direction and, moreover, that its accuracy in detecting changepoints is comparable to, or better than, existing algorithms while scaling linearly with the number of series.
Antimicrobial peptide polymers: no escape to ESKAPE pathogens—a review
Authors: Mukhopadhyay Songhita , Bharath Prasad A. S. , Mehta Chetan H. , Nayak Usha Y. 
Published: August 2020

Abstract
Antimicrobial resistance (AMR) is one of the significant clinical challenges and also an emerging area of concern arising from nosocomial infections of ESKAPE pathogens, which has been on the rise in both the developed and developing countries alike. These pathogens/superbugs can undergo rapid mutagenesis, which helps them to generate resistance against antimicrobials in addition to the patient’s non-adherence to the antibiotic regimen. Sticking to the idea of a ‘one-size-fits-all’ approach has led to the inappropriate administration of antibiotics resulting in augmentation of antimicrobial resistance. Antimicrobial peptides (AMPs) are the natural host defense peptides that have gained attention in the field of AMR, and recently, synthetic AMPs are well studied to overcome the drawbacks of natural counterparts. This review deals with the novel techniques utilizing the bacteriolytic activity of natural AMPs. The effective localization of these peptides onto the negatively charged bacterial surface by using nanocarriers and structurally nanoengineered antimicrobial peptide polymers (SNAPPs) owing to its smaller size and better antimicrobial activity is also described here.

Graphic abstract
Evaluation of Titania-Rich Slag Produced from Titaniferous Magnetite Under Fluxless Smelting Conditions
Authors: Geldenhuys I. J. , Reynolds Q. G. , Akdogan G. 
Published: August 2020

AbstractTitanium-bearing magnetite ore is generically defined as magnetite with > 1% titanium dioxide (TiO2) and is usually vanadium-bearing. The iron and titanium occur as a mixture of magnetite (Fe3O4) and ilmenite (FeTiO3) with vanadium oxide usually occurring within the solid solution of the titanium-bearing magnetite phase. These ores are currently widely processed in blast furnaces via modified ironmaking processes. Typically, vanadium is recovered as a by-product from the ironmaking process, while the diluted titania slag is stockpiled. Fluxless smelting in a direct-current open-arc furnace is proposed as an opportunity to improve iron and vanadium recovery and potentially unlock the titanium as a slag product. Slags produced from a pilot study are compared to industrial slags produced from ilmenite. The findings from the pilot test show that slag produced under fluxless smelting conditions in an open-arc electric furnace is remarkably similar to industrial ilmenite slags. The test conditions were varied to evaluate the slag and metal composition, and furnace operation, under increasing reducing conditions. The study showed that the slag and metal product was remarkably similar to industrial slag produced from ilmenite.