bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anemia and its association with Helicobacter pylori infection among adult dyspeptic patients attending Wachemo University Nigist Eleni Mohammad memorial Referral Hospital, Southwest Ethiopia
Authors: Haile Kassahun Tassow , Wolde Deneke , Tesfaye Girum , Yemane Tilahun , Timerga Abebe , Haile Admasu 
Published: March 2020

Abstract
Background: Anemia is a worldwide public health problem and also associated with H. pylori infection. Determining the association of anemia with H. pylori infection is important to develop evidence-based decision and intervention strategies. Association between anemia and H. pylori infection is not well known in Ethiopia. Thus, this study aimed to determine the association between anemia and H. pylori infection among adult dyspeptic patients attending Wachemo University Nigist Eleni Mohammad Memorial Referral Hospital in southwest Ethiopia.Method: A cross-sectional study was conducted from January to April 2019 involving 362 consecutive adult dyspeptic patients who came to the hospital during the study period. Socio-demographic, clinical and other related data were collected by structured questionnaires. Four milliliters of the venous blood sample was collected for hematological parameters analysis and blood film preparation. A stool sample was collected to detect H. pylori antigen and intestinal parasites. Data were analyzed by SPSS version 21. Logistic regression analyses were performed and p-value <0.05 was considered as statistically significant.Results: The overall prevalence of anemia among dyspeptic patients was 24.3% (95%CI: 19.9- 28.7). Among H.pylori infected participants 29.2% were anemic, of which 69.2% had mild anemia and 63.5% had normocytic normochromic anemia. Rural residence (AOR: 1.9, 95%CI: 1.1-3.3), H. pylori infection (AOR: 1.77, 95%CI: 1.05-2.98) and intestinal parasitic infection (AOR: 2.14, 95%CI: 1.14-4.03) were significantly associated with anemia.Conclusion: The prevalence of anemia in this study indicated that it is a moderate public health problem. Rural residence, H. pylori and intestinal parasitic infection were significantly associated with anemia. The findings of this study should be taken into account for the prevention and control of anemia among dyspeptic adults.
Characterizing glycosyltransferases by a combination of sequencing platforms applied to the leaf tissues of Stevia rebaudian
Authors: Zhang Shaoshan , Liu Qiong , Lyu Chengcheng , Chen Jinsong , Xiao Renfeng , Chen Jingtian , Yang Yunshu , Zhang Huihui , Hou Kai , Wu Wei 
Published: March 2020

Abstract
Background: Stevia rebaudiana (Bertoni) is considered one of the most valuable plants because of the steviol glycosides (SGs) that can be extracted from its leaves. Glycosyltransferases (GTs), which can transfer sugar moieties from activated sugar donors onto saccharide and nonsaccharide acceptors, are widely distributed in the genome of S. rebaudiana and play important roles in the synthesis of steviol glycosides. Results: Six stevia genotypes with significantly different concentrations of SGs were obtained by induction through various mutagenic methods, and the contents of seven glycosides (stevioboside, Reb B, ST, Reb A, Reb F, Reb D and Reb M) in their leaves were considerably different. Then, NGS and single-molecule real-time (SMRT) sequencing were combined to analyse leaf tissue from these six different genotypes to generate a more complete and correct full-length transcriptome of S. rebaudiana. Two phylogenetic trees of glycosyltransferases (SrUGTs) were constructed by the neighbour-joining method and successfully predicted the functions of SrUGTs involved in SG biosynthesis. With further insight into glycosyltransferases (SrUGTs) involved in SG biosynthesis, the weighted gene co-expression network analysis (WGCNA) method was used to characterize the relationships between SrUGTs and SGs, and forty-four potential SrUGTs were finally obtained. Of these potential SrUGTs, twenty-seven have complete ORFs and have not been verified to date, and enzyme assays were subsequently performed, but none of them had activity towards SGs. In addition, SrUGT (SrUGT88B1-1) could utilize UDP-glucose as a sugar donor to glycosylate isoquercetin to form three products containing one, two, and three glucoses, respectively.Conclusion: Combined with the results obtained by previous studies and those of this work, we systematically characterized glycosyltransferases in S. rebaudiana and confirmed that four enzymes (SrUGT85C2, SrUGT74G1, SrUGT76G1 and SrUGT91D2) are primarily involved in the glycosylation of steviol glucosides. Moreover, the complete and correct full-length transcriptome obtained in this study will provide valuable support for further research investigating S. rebaudiana.
Comparisons of Five Equations Used for Estimating the Glomerular Filtrations Rate in Chinese Adults
Authors: fu shuai , Yang Min , Xu Si , Wu Sha , Xiao Xiao , Hu Yugang , Li Xiaoning 
Published: March 2020

Abstract
Background We aimed to assess the performance of revised MDRD, CKD-EPI, BIS, FAS and XiangYa equation in Chinese adults Methods We collected blood biochemical data of 623 chinese adult hospitalised patients within 48 hours before they underwent 99m Tc-DTPA GFR measurement. We computed the bias (mGFR-eGFR), the precision (IQR) ,the accuray (P30）and root mean square error (RMSE) relative to mGFR of each equation to evaluate performance. The ROC curves, Kappa value of McNemar test, Bland-Altman plot and the Intraclass correlation coefficient (ICC) were used to evaluate diagnostic accuracy and concordance. Results Totally, the FAS combined Scr and cysC equation performed supreme accuracy(P30=57.5%, RMSE=19.26), the cysC-based equation performed superior to Scr-based equation. Detailed P30 of the CKD-EPI cysC , FAS cysC , MDRD, CKD-EPI Scr-cysC , CKD-EPI Scr , FAS Scr , XiangYa was 56.7%, 56.0%, 53.5%, 52.2%, 48.8%, 51.4%, 43.0%. The CKD-EPI cysC equation showed the lowest bias and the highest accuracy(bias=-2.23, P30=57.4%) in GFR<60ml/min/1.73m 2 , followed by the FASscr-cysC equation(bias=-6.89, P30=55.4%). The XiangYa equation perfomed best in GFR≥60ml/min/1.73m 2 while worst in GFR<60 ml/min/1.73m 2 with bias(-5.79 vs -19.05), IQR(18.21 vs 10.85), P30(86.2% vs 21.1%), RMSE(16.68 vs 21.34). The CKD-EPI cysC equation had the lowest bias and the best accuracy(bias=-2.23, P30=59.4%) in age ≥70 years adults, followed by the FAS Scr-cysC equation equivalented to BIS-2 Scr-cysC equation(bias -5.33 vs -4.90, P30=57.3%), while the XiangYa equation performed worstly (bias=-20.39, P30=26.6%). Best ROC AUC was gaven by the FAS Scr-cysC equation(0.951),so was it had the highest Kappa value(0.364). The lowest Bias showed in Bland-Altman plot was the CKD-EPI cysC equation(bias=7.46). The highest ICC value was gaven by the FAS Scr-cysC equation(0.921). Secondly, it was the XiangYa equation with the ICC of 0.912. Conclusions The FAS Scr-cysC equation is verified most suitable and simpler applied to Chinese population. The CKD-EPI cysC equation is appropriate used in moderately and severely injured GFR(CKD3-5stage) and Seniors over 70 years old. The XiangYa equation performed perfectly in slightly injured GFR (CKD1-2stage), while further verification of XiangYa equation in multiple region need to carried out especially in moderately and severely injured GFR and older adults.
An assessment of sensitivity biomarkers for urinary cadmium burden
Authors: Li Yuting , Wang Hongmei , Yu Jie , Yan Qiong , Hu Honggang , Zhang Lishu , Tian Tian , Peng Xianglei , Yang Shuo , Ke Shen 
Published: March 2020

Abstract
Background Excess cadmium (Cd) intake poses a general risk to health and to the kidneys in particular. Among indices of renal dysfunction under Cd burden measures are the urinary N-acetyl-β-D-glucosidase (UNAG) and urinary β 2 -microglobulin (Uβ 2 -MG) enzymes. However, the end-pointed values and the Cd burden threshold remain controversial because the scopes fluctuate widely. Methods To ascertain the clinical benchmark dose of urinary Cd (UCd) burden for renal dysfunction, 1595 residents near a Cd site were surveyed. Urine was sampled and assayed. A benchmark dose low (BMDL) was obtained by fitting UCd levels and index levels. Results We found that over 50% of the subjects were suffering from Cd exposure as their UCd levels far exceeded the national standard threshold of 5.000 μg/g creatinine (cr). Further analysis indicated that Uβ 2 -MG was more sensitive than UNAG for renal dysfunction. The BMDL for UCd was estimated as 3.486 U/g cr (male, where U is unit of enzyme) and 2.998 U/g cr (female) for UNAG. The BMDL for Uβ 2 -MG, which is released into urine from glomerulus after Cd exposure, was found to be 2.506 μg/g cr (male, where μg is the unit of microglobulin) and 2.236 μg/g cr (female). Conclusions Uβ 2 -MG is recommended as the sensitivity index for renal dysfunction, with 2.2 μg/g cr as the threshold for clinical diagnosis. Our findings suggest that Uβ 2 -MG is the better biomarker for exposure to Cd.
Simethicone administration improves efficacy and efficiency of esophagogastroduodenoscopy
Authors: Sun Xiaotian , Xu Yang , Zhang Xueting , Ma Cuiyun , Li Aitong , Yu Haiyan , Zhang Weihua , Zhang Hanqing , Yang Teng , Zu Shengzhou , Liu Yan , LU Zheng 
Published: March 2020

Abstract
Background: Esophagogastroduodenoscopy is very useful in diagnosing and treating upper gastrointestinal mucosal disorders, but too much foam and water in stomach decrease its diagnostic efficiency. Simethicone administration can help remove excessive foam. Aims: To determine the optimal simethicone administration strategies in a comparative randomized controlled clinical trial.Methods: Adult outpatients with indications for esophagogastroduodenoscopy were enrolled and randomly divided into Group 1 (simethicone solution intake 20-30 min before procedure, n=110), Group 2 (simethicone solution intake 31-60 min before procedure, n=92) and Group 3 (simethicone solution intake >60 min before procedure). Primary and secondary outcome were procedure time and the patients' satisfaction after the examination. All symptoms like abdominal pain, distension were recorded.Results: No statistically significant differences were found on the patients’ demographic and clinical features, and mean examination time (all P values >0.05). The distribution of patients with different endoscopic and pathological diagnosis was comparable among three groups, respectively (P=0.607; P=0.289). However, the proportion of patients with Gastric Cleanness Grade A was most in Group 2 (n=73, 79.3%), and patient proportion with Gastric Cleanness Grade C was most found in Group 1 (n=72, 65.5%), which was greatly different (P<0.001). There was no statistically significant difference on the satisfaction scores [immediately 6 (3-8) vs. 6 (1-10) vs. 6 (1-9), P=0.533; 2h after 10 (8-10) vs. 10 (10-10) vs. 10 (8-10), P=0.463].Conclusion: Simethicone solution intake 31-60 min before esophagogastroduodenoscopy can help obtain best gastric cleanness, which is recommended in clinical practice (registered at ClinicalTrials.gov, NCT03776916).
The role of empowerment in the use of modern contraceptives among women in need of family planning in Burkina Faso: A multilevel analysis
Authors: SOME Sylvain Y. M. , Pu Christy , Huang Song-Lih 
Published: March 2020

Abstract
Background

In Burkina Faso, women still have difficulty satisfying their family planning demand because of the patriarchal and gender-unequal society. Despite evidence that women’s empowerment can help, few studies have measured its impact at both community and household levels. Taking into account these two parameters, we looked into the association between women’s empowerment and modern contraception use among Married Women of Reproductive Age (MWRA) with no desire for having children in Burkina Faso.

Methods

Using the 2010 Demographic and Health Survey (DHS), we analyzed data from 4714 MWRA with family planning needs from 573 communities. Indicators of gender equality at the community level were composed of aggregated variables for each primary sampling unit, and domains of women’s agency in households matters were derived with principal component analysis. A multilevel logistic regression model was used to gauge the effects of empowerment on modern contraceptives use adjusted for household socioeconomic status and demographics of women.

Results

Among MWRA, 30.8% satisfied their demand for family planning using modern methods. At the community level, higher women’s assets ownership (aOR 1.26, CI 1.04 - 1.54), secondary education (aOR 1.45, OR 1.08 - 1.64), and exposure to family planning messages (aOR 1.33, CI 1.08 - 1.64) were associated with more modern contraceptive use; higher ideal number of children was negatively associated (aOR 0.76, CI 0.61 - 0.95). Unexpectedly, higher community prevalence of female genital mutilation was positively associated with contraceptive use (aOR 1.25, CI 1.03-1.52). Women’s agency in household matters, including opposing domestic violence, involved with decisions and enjoying freedom in seeking healthcare were positively associated with use, but only the last domain remained significant in multilevel analysis (aOR 1.29, CI 1.08 - 1.54). Living in richer household, being older, and having secondary education level were also positively associated with modern contraceptive use.

Conclusion

Gender equality at the community level and women’s situation in the household constitute the context in which women’s demand for family planning is determined. Therefore, promoting gender equality and ensuring women’s entitlement to make life choices have the potential to increase modern contraceptive coverage along with improved life conditions.
Transcriptomic analysis of Bursaphelenchus xylophilus treated by a potential phytonematicide, punicalagin
Authors: Guo Qun-Qun , Du Gui-Cai , Zhang Ting-Ting , Wang Mei-Juan , Wang Chao , Qi Hong-Tao , Li Rong-Gui 
Published: March 2020

Abstract
Punicalagin showed significant nematotoxic activity against pine wood nematode (PWN), Bursaphelenchus xylophilus, in the authors’ previous research. The authors performed high-throughput transcriptomic sequencing of punicalagin-treated nematodes to generate clues for its nematotoxic mechanism of action. The authors identified 2,575 differentially expressed genes, 1,428 of which were up-regulated and 1,147 down-regulated. Based on a comprehensive functional in silico analysis, the authors speculate that PWN may respond to the stimulus of punicalagin through phagosome, endocytosis, peroxisome and MAPK signaling pathways. In addition, punicalagin could greatly affect PWN energy metabolism including oxidative phosphorylation. The genes encoding twitchin and a nematode cuticular collagen could be crucial regulation targets of punicalagin, which might contribute to its nematotoxic activity against PWN.
Parental internalizing symptoms as predictors of anxiety symptoms in clinic-referred children
Authors: Fjermestad Krister Westlye , Lium Christina , Heiervang Einar R. , Havik Odd E. , Mowatt Haugland Bente Storm , Bjelland Ingvar , Henningsen Wergeland Gro Janne 
Published: March 2020

Abstract

Background:
Mothers’ and fathers’ internalizing symptoms may influence children’s anxiety symptoms differently.

Objective:
To explore the relationship between parental internalizing symptoms and children’s anxiety symptoms in a clinical sample of children with anxiety disorders.

Method:
The sample was recruited through community mental health clinics for a randomized controlled anxiety treatment trial. At pre-intervention, children (n = 182), mothers (n = 165), and fathers (n = 72) reported children’s anxiety symptoms. Mothers and fathers also reported their own internalizing symptoms. The children were aged 8 to 15 years (M
age = 11.5 years, SD = 2.1, 52.2% girls) and all had a diagnosis of separation anxiety, social phobia, and/or generalized anxiety disorder. We examined parental internalizing symptoms as predictors of child anxiety symptoms in multiple regression models.

Results:
Both mother and father rated internalizing symptoms predicted children’s self-rated anxiety levels (adj. R
2 = 22.0%). Mother-rated internalizing symptoms predicted mother-rated anxiety symptoms in children (adj. R
2 = 7.0%). Father-rated internalizing symptoms did not predict father-rated anxiety in children.

Conclusions:
Clinicians should incorporate parental level of internalizing symptoms in their case conceptualizations.
The Problems of Islamic Religious Education Teacher for Curriculum Development in Transmigration Area
Authors: Shalihin Rahmat Ryadhush , Widodo Hendro 
Published: March 2020

This paper aims to analyze the problematics of teacher to develop curriculum Islamic Religious Education . This research used qualitative methods and data were gathered from literature reviews, observations, and in-depth interviews from teacher and student. The data analyzed with reduction, presentation, and conclusion. The results of this research revealed that The problems of Islamic education teachers in transmigration areas can be summarized into five things. They are first, they have to deal with active time management Secondary learning, management documents, such as students daily paper sheets, Learning Perfoming Plan / RPP, and other extra tasks from school and headmaster to the teacher for some training. Third, the lack of teaching materials causes. Fourth, the problem of conditional and competency teachers. Fifth, they have passive studentsKeywords: Islamic education; transmigration era, problem teacher; curriculum developmentAbstrakMakalah ini bertujuan untuk menganalisis problematika guru dalam mengembangkan kurikulum Pendidikan Agama Islam. Penelitian ini menggunakan metode kualitatif dan data dikumpulkan dari tinjauan literatur, observasi, dan wawancara mendalam dari guru dan siswa. Data dianalisis dengan reduksi, presentasi, dan kesimpulan. Hasil penelitian ini mengungkapkan bahwa masalah guru pendidikan Islam di daerah transmigrasi dapat diringkas menjadi lima hal. Mereka adalah yang pertama, mereka harus berurusan dengan manajemen waktu aktif Pembelajaran sekunder, dokumen manajemen, seperti kertas harian siswa, Rencana Pembelajaran Perfoming / RPP, dan tugas tambahan lainnya dari sekolah dan kepala sekolah kepada guru untuk beberapa pelatihan. Ketiga, kurangnya bahan ajar menyebabkan. Keempat, masalah guru bersyarat dan kompetensi. Kelima, mereka memiliki siswa pasifKata kunci: pendidikan Islam; era transmigrasi, guru bermasalah; pengembangan kurikulum
Needs Analysis of The Islamic Arabic Material Teaching Based on Communicative for University Students
Authors: Mawanti Dwi 
Published: March 2020

Teaching materials are one of the important components needed in the learning process. The Arabic language course program is a compulsory course for second semester students department in Islamic Education (PAI) Walisongo State Islamic University (UIN) Semarang. This study aims to describe the students' needs for communicative Arabic based teaching materials for students department in Islamic education at the Faculty of Tarbiyah and Education (FITK) UIN Walisongo Semarang. The results of this study indicate that 41.56% of students require renewal of Arabic course material developed with communicative principles that contain topics of Islamic education in accordance with the department of Islamic education. these materials include Quran-Hadith, Aqedah, Tafsir, Sufism, Fiqh and Islamic History.. AbstrakBahan ajar adalah salah satu komponen penting yang dibutuhkan dalam proses pembelajaran. Program kursus Bahasa Arab adalah kursus wajib untuk mahasiswa semester dua di jurusan Pendidikan Agama Islam (PAI) Universitas Islam Negeri (UIN) Walisongo Semarang. Penelitian ini bertujuan untuk mendeskripsikan kebutuhan siswa akan bahan ajar Bahasa Arab berbasis komunikatif untuk siswa jurusan pendidikan agama islam di Fakultas Ilmu tarbiyah dan kependidikan (FITK) UIN Walisongo Semarang. Hasil penelitian ini menunjukkan bahwa 41,56% siswa membutuhkan pembaharuan materi kursus bahasa Arab yang dikembangkan dengan prinsip-prinsip komunikatif yang berisi topik-topik pendidikan Islam sesuai dengan departemen pendidikan Islam. bahan-bahan ini termasuk Quran-Hadits, Akidah, Tafsir, Sufisme, Fiqh dan Sejarah Islam.
KARPAL TÜNEL SENDROMLU HASTALARDA KAS KUVVET VE ENDURANSI ÜST EKSTREMİTE FONKSİYONLARINI ETKİLER Mİ?
Authors: KESKİNÖZ Petek Canova , ERGİN Gülbin , BAKIRHAN Sekan , ÖZDEN Ayşe 
Published: March 2020

Amaç:
Karpal Tünel Sendromu (KTS) elde
duyusal ve motor kayıplar ile ortaya çıkan bir tuzak nöropatisidir. KTS ile
hastaların azalan kas kuvvetleri ve enduransları fonksiyonel aktivitelerde
yetersizliklere neden olabilir. Bu
çalışma KTS’li hastalarda kas kuvvet ve enduransının üst ekstremite
fonksiyonelliği üzerine olan etkisini araştırmak amacı ile planlandı.Yöntem:
Çalışmaya KTS tanısı alan 45 hasta (yaş ortalaması 49.44±9.04 yıl) dâhil
edildi. KTS’li hastaların üst ekstremite
kas enduransı, desteksiz kol testi (1. ve 2. diagonal paternde) ile, üst ekstremite kas kuvveti Hand Held
Dinamometre ile, kavrama kuvvetleri hand dinamometre, parmak
kavrama kuvveti digital pinçmetre ile, üst ekstremite fonksiyonelliğini
değerlendirmek için ise DASH (Kol, Omuz
ve El Yaralanmaları Anketi) kullanıldı.Sonuçlar:
Hastaların
DASH skorları ile üst ekstremite omuz fleksör, ekstansör, abduktör, eksternal
rotatör, dirsek fleksör-ekstansör, el bileği ekstansör ve tüm pinch kuvvetleri
arasında negatif yönde anlamlı ilişki olduğu belirlendi (p&lt;0,05). Hastaların
DASH skorları ile üst ekstremite desteksiz kol testi (1. ve 2. diagonal
paternde) sonuçları arasında negatif yönde anlamlı ilişki olduğu bulundu (p&lt;0,05).

Tartışma:
Karpal tünel sendromlu hastalarda özellikle azalmış kassal endurans ve kassal
kuvvet üst ekstremite fonksiyonlarında azalmalara neden olmaktadır. Karpal
tünel sendromlu hastalarda ağrı ve benzeri semptomlar ile azalan üst ekstremite
fonksiyonelliğini arttırmak için kassal kuvvetin yanısıra uzun dönemde kassal
endurans egzersizlerinin de fizyoterapi programlarına dahil edilmesi
gerektiğini düşünmekteyiz.Anahtar
sözcükler: Lateral epikondilit, dirsek,
kuvvet, endurans, fonksiyon
EL YARALANMASI OLAN KİŞİLER İŞE GERİ DÖNEBİLİYOR MU?
Authors: SIĞIRTMAÇ İlkem Ceren , ÖKSÜZ Çiğdem 
Published: March 2020

Amaç: El yaralanması geçiren kişilerin işe geri dönüş sürecini ve bu süreci etkileyebilecek faktörleri
belirlemekti.
Yöntem: Çalışmaya el yaralanması geçiren 47 kişi katıldı. Bireylerin demografik bilgileri ve yarı
yapılandırılmış görüşme yöntemi kullanılarak işe geri dönüş süreçleri ile ilgili bilgiler kaydedildi.
Ayrıca işe geri dönemeyen kişilerin fonksiyonel kapasitesini belirmek amacı ile Kol, Omuz ve El
Sorunu Anketi değerlendirmesi yapıldı. Görüşmeler yüz yüze veya telefon aracılığı ile tamamlandı.
Sonuçlar: Bireylerin kırk beşi (% 96) işe geri dönerken, iki (% 4) bireyin işe geri dönmediği bulundu.
İşe geri dönen kişilerin yaralanma tipleri, kırık (n=17), yumuşak doku (n=7), sinir yaralanması (n=12)
ve ezilme yaralanması/replantasyon/amputasyon (n=9) olarak sınıflandırıldı. İşe geri dönen kişilerin
işe geri dönüş süresi ortanca değeri 45 gün (IQR=7-60) ve rapor süresi ortanca değeri 45 gün
(IQR=45-90) olarak bulundu. Onbir birey (% 24) iş yerinde yaralanırken, 34 birey (% 76) iş yeri
dışında yaralanmıştı. Otuzdokuz bireyin (% 87) yaralanma öncesi ve sonrası işleri aynıydı. İşe geri
dönen kişiler için cinsiyet, medeni durum, yaralanma yeri, yaralanan taraf el, yaralanma öncesi ve
sonrası iş durumu, işe geri dönüş süresi, rapor süresi, iş performansı ve tatmini karşılaştırmalarında
istatistiksel olarak fark anlamlı bulunamadı (p>0,05). İşe geri dönemeyen iki hastanın, tıbbı ve
hukuki süreçlerinin halen devam etmesi ve fonksiyonel anlamda yeterli olmamaları nedeni ile işe
geri dönmedikleri belirlendi.
Tartışma: El yaralanması geçiren kişilerin yaralanma sonrası işe geri dönüş sürecindeki
problemlerin rapor süresi içerisinde azaldığı ve bu süre sonunda yaralanma tipinden bağımsız
olarak kişilerin büyük bir kısmının işe geri dönebildikleri sonucuna varılmıştır.
Anahtar Kelimeler: İşe Geri Dönüş; El Yaralanmaları; Meslek.