bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of heat treatment and salt addition on the physicochemical properties and quality of fresh noodles
Authors: Zhang Yanyan , Liu Chong , Hong Jing , Li Limin , Zheng Xueling , Bian Ke , Guan Erqi 
Published: January 2020

SummaryHeat treatment and salt addition on the physicochemical properties and quality of fresh noodles were investigated. The water activity was decreased, while the bound water content was increased after heat treatment, and this effect was dependent on the treated intensity and salt concentration, which extended the shelf life of noodles. The content of SDS‐soluble protein was decreased after heat treatment, and this effect was dependent on the treated intensity. However, 3% salt concentration can reduce the aggregation of SDS‐soluble protein. The paste viscosities were reduced, whereas the gelatinisation temperatures increased after heat treatment, and the variation was increased with increasing salt concentration. The hardness and chewiness of cooked noodles were increased after heat treatment, but adding salt reduced this effect. Results showed the quality of heat‐treated noodles can be precisely controlled by the addition of salt, and the optimal treatment condition was 98 °C and 2% salt concentration.
Molecular characterization of insulin‐like peptides in the brown planthopper, Nilaparvata lugens (Hemiptera: Delphacidae)
Authors: Xue W.‐H. , Liu Y.‐L. , Jiang Y.‐Q. , He S.‐F. , Wang Q.‐Q. , Yang Z.‐N. , Xu H.‐J. 
Published: January 2020

AbstractInsulin‐like peptides (ILPs) including insulin, insulin‐like growth factor (IGF) and relaxin are evolutionarily conserved hormones in metazoans, and they are involved in diverse physiological processes. The migratory brown planthopper (BPH), Nilaparvata lugens, encodes four ILP genes (Nlilp1, Nlilp2, Nlilp3 and Nlilp4) but their physiological roles are largely unknown. Sequence analysis showed that NlILP1 contained a relaxin‐specific G protein‐coupled receptor‐binding motif and a variant motif of cysteine residues, and NlILP2 and NlILP4 resembled vertebrate IGFs. RNA interference (RNAi)‐mediated gene silencing showed that depletion of each of Nlilp1, 2 and 3 significantly delayed the developmental duration of nymphs, and this effect could be exacerbated by double or triple gene depletion. Depletion of Nlilp1, Nlilp2 or Nlilp3 induces the accumulation of glucose, trehalose and glycogen, which is contradictory to depletion of the insulin receptor (NlInR1) in the BPH. Depletion of Nlilp1 significantly enhanced starvation resistance in both females and males although its extent was smaller than NlInR1 depletion. A parental RNAi assay showed that depletion of each of Nlilp1–4 dramatically impaired female fecundity. These findings indicate that NlILP1–4 have redundant and distinct roles in physiological processes in the BPH, thereby enhancing our understanding of the contribution of each NlILP to the ecological success of this species in natural habitats.
Implementation of a community‐based hypertension control program in Matanzas, Cuba
Authors: Valdés González Yamilé , Campbell Norm R.C. , Pons Barrera Edelys , Calderón Martínez Marcy , Pérez Carrera Alina , Morales Rigau José Manuel , Afonso de León Jose Alberto , Pérez Jiménez Vivian , Landrove Rodríguez Orlando , DiPette Donald J. , Giraldo Gloria , Orduñez Pedro 
Published: January 2020

AbstractIncreased blood pressure is a leading risk factor for death worldwide, and improving the control of hypertension is a major health goal to reduce non‐communicable disease. Thus, in 2016, as part of a regional effort between the Pan American Health Organization and Cuban Ministry of Public Health to reduce cardiovascular risk and disease, a community demonstration project was implemented to enhance hypertension control. The intervention project was in a population of 25 868 people served by the Carlos Verdugo Martínez Polyclinic in Matanzas, Cuba. The project implemented interventions currently recommended in the World Health Organization HEARTS modules, including a standardized clinical training program with certification for blood pressure measurement, routine screening for hypertension in clinics and in the community, a simple directive pharmacologic treatment algorithm, and a registry with performance reporting and feedback. Qualitative and quantitative program monitoring and evaluation was established. In a 2010 national survey, the prevalence of hypertension and the rate of hypertension control were estimated to be 31% and 36%, respectively. Following less than one year of the full implementation of the program, the prevalence of hypertension, proportion of the hypertensive population registered as having hypertension, proportion of those drug‐treated who were controlled, and estimated population rate of control were 30%, 90%, 68%, and 58%, respectively. Based on these positive results, the program has been expanded to include another demonstration program initiated in a second region. In addition, preliminary efforts to disseminate and scale‐up aspects of the program to the full Cuban population have started.
Publication trends in hidradenitis suppurativa from 2008 to 2018
Authors: Savage K.T. , Gonzalez Brant E. , Flood K.S. , Salian P. , Porter M.L. , Kimball A.B. 
Published: January 2020

AbstractBackgroundIncreased interest in hidradenitis suppurativa (HS) research is encouraging. A critical analysis of the state of HS literature may demonstrate the strength of existing knowledge and highlight current gaps.ObjectivesTo analyse changes in HS literature from 2008 to 2018 with focus on quantity and quality of annual publications.MethodsReview of all indexed publications reporting on HS on PubMed. Publications were categorized based on study design, study topic and treatment type where applicable. Publications were dichotomized into high level of evidence and low level of evidence groups. Linear regression analyses were performed to investigate the change in publication number over time. Annual average growth rate and distribution of high versus low level of evidence publications were calculated.ResultsPublication number increased over time overall (R2 = 0.64, P = 0.003) and for all publication types except randomized clinical trials. Case reports and case series represented the majority of HS publications (n = 479, 40.3%). Treatment was the main focus of publications (n = 445, 37.6%) with increasing interest in medical management evident in recent years. Distribution of low level of evidence studies (n = 974) compared with high level of evidence studies over time (n = 209) was significant (x2: 11.45, P = 0.0007). High level of evidence studies had a higher average annual growth rate (49.9%) compared with low level of evidence studies (23.7%). Few randomized clinical trials were performed (n = 16), focusing equally on medical or procedural treatments.ConclusionsHidradenitis suppurativa research is undergoing a tremendous shift, suggesting rapid maturation of the field. Current HS literature, however, remains primarily based on limited clinical observation data, with a particular lack of randomized clinical trials. Despite this, the increase in high level of evidence studies is encouraging and may herald a shift towards improved disease understanding and treatment paradigms.
Interprofessional Education Between Midwifery Students and Obstetrics and Gynecology Residents: An American College of Nurse‐Midwives and American College of Obstetricians and Gynecologists Collaboration
Authors: Avery Melissa D. , Jennings John C. , Germano Elaine , Andrighetti Tia , Autry Amy M. , Dau Kim Q. , Krause Susan Agard , Montgomery Owen C. , Nicholson Tonya B. , Perry Audrey , Rauk Phillip N. , Sankey Heather Z. , Woodland Mark B. 
Published: January 2020

AbstractDespite areas of excellence, US perinatal care outcomes lag behind most developed countries. In addition, a shortage and maldistribution of health care providers exists. The American College of Nurse‐Midwives and the American College of Obstetricians and Gynecologists (ACOG) partnered to obtain funding to develop interprofessional education modules and other learning activities for midwifery students and obstetrics and gynecology residents in 4 demonstration sites. The multidisciplinary 2016 ACOG document Collaboration in Practice: Implementing Team‐Based Care was adopted as a framework. Core competencies of values and ethics, roles and responsibilities, interprofessional communication, and teams and teamwork developed by the Interprofessional Education Collaborative were used to guide the work. Seven modules have been developed including guiding principles, patient‐centered care, role clarification, collaborative practice, history and culture, care transition, and difficult conversations. Learners participate in laboratory and simulation activities and work together in clinical care settings. Stakeholder experiences as well as barriers to implementation are discussed. Learning materials and activity descriptions are open resourced and shared on a project website for use by programs interested in implementing an interprofessional curriculum. Ongoing formal evaluation including pilot testing of a program evaluation method is described.
Endodontic therapy and incident cardiovascular disease: The Atherosclerosis Risk in Communities (ARIC) study
Authors: Cowan Logan T. , Lakshminarayan Kamakshi , Lutsey Pamela L. , Beck James , Offenbacher Steven , Pankow James S. 
Published: January 2020

AbstractObjectivesPrevious studies on a potential association between endodontic infection (EI) and cardiovascular disease (CVD) produced mixed results. Endodontic treatment (ET) may also be linked to cardiovascular risk, as a marker for prior chronic dental infection and subclinical EI in other teeth. We tested the hypothesis that ET is associated with elevated risk of coronary heart disease (CHD), ischemic stroke (IS), heart failure (HF), or venous thromboembolism (VTE).MethodsARIC participants who completed the dental ancillary study exam 4 (1996–1998; n = 6,638) were included in the analyses. Participants were followed through 2013 for CHD, stroke, and HF and 2011 for VTE. Cox‐proportional hazards regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for CHD, IS, HF, and VTE across ET classifications adjusting for age, sex, race/center, education, income, smoking, alcohol consumption, BMI, statin use, family history of CHD, physical activity, diet quality, insurance status, last dental visit, dental visit frequency, having a current dentist, and tooth loss due to gum disease.ResultsAmong participants, 21.0% reported a single ET, while 28.5% reported multiple ETs. Over a median of 15.8 years of follow‐up, there were 506 incident CHD events, 311 IS events, 739 HF events, and 219 VTE events. There were no significant associations between self‐reported history of ET and any of our outcomes (HR (95%CI): CHD = 1.16 (0.87,1.44), IS = 0.77 (0.55,1.09), HF = 1.00 (0.81,1.24), VTE = 0.98 (0.67,1.43)) after adjustment.ConclusionsOur results do not support an independent association between ET and development of CHD, IS, HF, or VTE.
Responses of Two Coastal Algae (Skeletonema costatum and Chlorella vulgaris) to Changes in Light and Iron Levels1
Authors: Wang Bo , Chen Min , Zheng Minfang , Qiu Yusheng 
Published: January 2020

Iron (Fe) is essential for phytoplankton growth and photosynthesis, and is proposed to be an important factor regulating algal blooms under replete major nutrients in coastal environments. Here, Skeletonema costatum, a typical red‐tide diatom species, and Chlorella vulgaris, a widely distributed Chlorella, were chosen to examine carbon fixation and Fe uptake by coastal algae under dark and light conditions with different Fe levels. The cellular carbon fixation and intracellular Fe uptake were measured via 14C and 55Fe tracer assay, respectively. Cell growth, cell size, and chlorophyll‐α concentration were measured to investigate the algal physiological variation in different treatments. Our results showed that cellular Fe uptake proceeds under dark and the uptake rates were comparable to or even higher than those in the light for both algal species. Fe requirements per unit carbon fixation were also higher in the dark resulting in higher Fe: C ratios. During the experimental period, high Fe addition significantly enhanced cellular carbon fixation and Fe uptake. Compared to C. vulgaris, S. costatum was the common dominant bloom species because of its lower Fe demand but higher Fe uptake rate. This study provides some of the first measurements of Fe quotas in coastal phytoplankton cells, and implies that light and Fe concentrations may influence the phytoplankton community succession when blooms occur in coastal ecosystems.
Blue‐blocking glasses as additive treatment for mania: Effects on actigraphy‐derived sleep parameters
Authors: Henriksen Tone E. G. , Grønli Janne , Assmus Jörg , Fasmer Ole Bernt , Schoeyen Helle , Leskauskaite Ieva , Bjorke‐Bertheussen Jeanette , Ytrehus Kjersti , Lund Anders 
Published: January 2020

AbstractImprovement of sleep is a central treatment goal for patients in a manic state. Blue‐blocking (BB) glasses as adjunctive treatment hasten overall recovery from mania. This method is an evolvement from dark therapy and builds on the discovery of the blue‐light‐sensitive retinal ganglion cell that signals daytime to the brain. We report effects of adjunctive BB glasses on actigraphy‐derived sleep parameters for manic inpatients as compared to placebo. Hospitalized patients with bipolar disorder in a manic state aged 18–70 years were recruited from five clinics in Norway from February 2012 to February 2015. The participants were randomly allocated to wearing BB glasses or placebo (clear glasses) as an adjunctive treatment from 18:00 to 08:00 hours for seven consecutive nights. Sleep and wake were monitored by actigraphy. From 32 eligible patients, 10 patients in each group qualified for the group analyses. The BB group's mean sleep efficiency was significantly higher at night 5 as compared to the placebo group (92.6% vs. 83.1%, p = .027). The 95% confidence interval (CI) was 89.4%–95.8% in the BB group and 75.9%–90.3% in the placebo group. There were fewer nights of interrupted sleep in the BB group: 29.6% versus 43.8% in the placebo group. The BB group received less‐intensive sleep‐promoting pharmacological treatment and showed significantly higher sleep efficiency and more consolidated sleep as compared to the placebo group. Our findings suggest sleep‐promoting effects through deactivating mechanisms. Adjunctive BB glasses seem to be useful for improving sleep for manic patients in the hospital setting.
A novel Pezizomycotina‐specific protein with gelsolin domains regulates contractile actin ring assembly and constriction in perforated septum formation
Authors: Mamun Md. Abdulla Al , Katayama Takuya , Cao Wei , Nakamura Shugo , Maruyama Jun‐ichi 
Published: January 2020

AbstractSeptum formation in fungi is equivalent to cytokinesis. It differs mechanistically in filamentous ascomycetes (Pezizomycotina) from that of ascomycete yeasts by the retention of a central septal pore in the former group. However, septum formation in both groups is accomplished by contractile actin ring (CAR) assembly and constriction. The specific components regulating septal pore organization during septum formation are poorly understood. In this study, a novel Pezizomycotina‐specific actin regulatory protein GlpA containing gelsolin domains was identified using bioinformatics. A glpA deletion mutant exhibited increased distances between septa, abnormal septum morphology and defective regulation of septal pore closure. In glpA deletion mutant hyphae, overaccumulation of actin filament (F‐actin) was observed, and the CAR was abnormal with improper assembly and failure in constriction. In wild‐type cells, GlpA was found at the septum formation site similarly to the CAR. The N‐terminal 329 residues of GlpA are required for its localization to the septum formation site and essential for proper septum formation, while its C‐terminal gelsolin domains are required for the regular CAR dynamics during septum formation. Finally, in this study we elucidated a novel Pezizomycotina‐specific actin modulating component, which participates in septum formation by regulating the CAR dynamics.
A Response to Paul Griffiths’ Annihilationist Proposal
Authors: Brotherton Joshua R. 
Published: January 2020

AbstractIn his recent influential theological work, Paul Griffiths, the esteemed Buddhism scholar and Anglican convert to Catholicism, proposes, among other things, that annihilationism is a viable option for Christians, including Catholics, despite apparent magisterial prohibition. He argues, in effect, that every creature must be naturally mortal because bodily, including the angels. Therefore, de facto immortal creatures are not immortal by nature, but by a positive act of God in addition to the creative act. Accordingly, it makes no sense to assert the existence of an eternal hell. Rather, since sin is fundamentally corrosive, those who opt to continue down the rabbit's hole of sin literally become nothing. Hell, then, is a no‐place and a no‐time. Hence, as long as the damned continue to exist, they have the opportunity for eventual redemption as for eventual self‐annihilation. Griffiths attempts to defend this thesis in dialogue with Augustine, in particular, to the neglect of Aquinas, except to argue that Aquinas’ own arguments for the natural immortality of the human soul are incoherent. I will argue instead that spiritual being exists, that it is naturally immortal, that Aquinas demonstrates both, and that even an Augustinian such as Joseph Ratzinger recognizes Aquinas’ theological insights and builds on them.
Evolutionary strategies drive a balance of the interacting gene products for the CBL and CIPK gene families
Authors: Zhang Xiaoxia , Li Xiaoxia , Zhao Ran , Zhou Yun , Jiao Yuannian 
Published: January 2020

Summary

Genes encoding interacting proteins tend to be co‐retained after whole‐genome duplication (WGD). The preferential retention after WGD has been explained by the gene balance hypothesis (GBH). However, small‐scale duplications could independently occur in the connected gene families. Certain evolutionary strategies might keep the dosage balanced.

Here, we examined the gene duplication, interaction and expression patterns of calcineurin B‐like (CBL) and CBL‐interacting protein kinase (CIPK) gene families to understand the underlying principles.

The ratio of the CBL and CIPK gene numbers evolved from 5 : 7 in Physcomitrella to 10 : 26 in Arabidopsis, and retrotransposition, tandem duplication, and WGDs contributed to the expansion. Two pairs of CBLs and six pairs of CIPKs were retained after the α WGD in Arabidopsis, in which specific interaction patterns were identified. In some cases, two retained CBLs (CIPKs) might compete to interact with a sole CIPK (CBL). Results of gene expression analyses indicated that the relatively over‐retained duplicates tend to show asymmetric expression, thus avoiding competition.

In conclusion, our results suggested that the highly specific interaction, together with the differential gene expression pattern, jointly maintained the balanced dosage for the interacting CBL and CIPK proteins.
A randomized controlled trial examining the impact of individual trauma‐focused therapy for individuals receiving group treatment for depression
Authors: Dominguez Sarah , Drummond Peter , Gouldthorp Bethanie , Janson Diana , Lee Christopher William 
Published: January 2020

ObjectivesAdverse life events are associated with increased likelihood of depression and poorer prognosis. Trauma‐focused treatments (TFT) appear to be effective in decreasing comorbid depressive symptoms. Accordingly, the aim of this study was to evaluate the effectiveness of a TFT on the memories of aversive events for individuals with a primary diagnosis of depression.MethodsA randomized controlled trial was conducted with 49 participants recruited from a 10‐day outpatient group programme. All participants showed symptoms of depression with a subgroup (80%) meeting the DSM‐5 criteria for a major depressive episode. Participants received treatment as usual (TAU); three additional individual trauma‐focused sessions; or three additional individual assertiveness training sessions. Participants were assessed with regards to depression diagnosis and related symptoms.ResultsFor participants with a major depressive episode, the addition of trauma‐focused sessions significantly increased the likelihood of remission when compared to TAU, or additional assertiveness training. While no significant treatment difference was noted in depressive symptom change post‐treatment, six weeks after treatment those who received an adjunct treatment were more likely to maintain treatment gains than those who received TAU. Furthermore, at 12‐week follow‐up, participants who received a TFT reported significantly fewer depressive symptoms than those who received assertiveness training.ConclusionsWhile differences in outcomes were minimal immediately post‐treatment, differences among treatment groups increased over time. Thus, as few as three additional TFT sessions may impact positively on symptom change for people completing a group programme for the treatment of depression.Practitioner points

Depression is the greatest cause of disability worldwide.

Adverse experiences are linked with an increased likelihood of depression, more severe symptoms and poor treatment outcomes following evidence‐based interventions.

As few as three trauma‐focused sessions can improve treatment outcomes in terms of depression diagnosis and related symptoms for individuals receiving group cognitive behavioural therapy.
A novel mutation of keratin 5 in epidermolysis bullosa simplex with migratory circinate erythema
Authors: Yalici‐Armagan Basak , Kabacam Serkan , Taskiran Zihni Ekim , Gököz Özay , Utine Gülen Eda , Ersoy‐Evans Sibel 
Published: January 2020

AbstractEpidermolysis bullosa simplex migratory circinate erythema (EBS‐Migr) is an uncommon subtype of EBS. We report a case of EBS‐MIGR with a novel heterozygous pathogenic mutation in exon 9 (frameshift deletion c.1650delC) and likely benign heterozygous mutation in exon 2 (missense c.591C > A) of keratin 5. This novel pathogenic mutation inKRT5expands the molecular spectrum of this rare subtype of EBS.
Anterior insula activity and the effect of agency on the Stimulus‐Preceding Negativity
Authors: Hackley Steven A. , Hirao Takahiro , Onoda Keiichi , Ogawa Keiko , Masaki Hiroaki 
Published: January 2020

AbstractIf you know that you are the author of a freely chosen action and that you bear responsibility for its outcome, then you are said to have “a sense of agency.” When there is a delay between action and outcome, this response must be remembered if you are to learn from the experience. Previous studies have shown that the Stimulus‐Preceding Negativity (SPN) recorded during the delay interval is larger under conditions that foster a sense of agency. In an EEG experiment (N = 27), we confirmed that the SPN is larger when participants have a choice between two responses in a gambling task as compared to when there is only a single button and the computer determines the monetary outcome. This SPN agency effect was largest over right prefrontal cortex and it did not vary significantly between trial blocks in which only gains or only losses were possible. Participants in a second experiment (N = 26) performed the same task while activity in anterior insular cortex, a known SPN generator, was measured via functional magnetic resonance image (fMRI). An essentially identical pattern of results was obtained: Activity was greater on choice than no‐choice trials, especially for the right hemisphere, and no effect of contextual valence was observed. Although parallel observations such as these cannot warrant causal inference, our findings are consistent with the assumption that anterior insular cortex contributes to the effect of agency on the SPN.