bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with mental health outcomes among health care workers in the Fangcang shelter hospital in China
Authors: Gu Yingqi , Zhu Yi , Xu Guangxing 
Published: December 2020

Background: Faced with surging infections and considering that 80% of cases were mild and moderate, the city government transformed stadiums and exhibition centers into the Fangcang shelter hospitals (temporary treatment centers) in Wuhan. Aim: The aims of this study were to evaluate psychological impact on health care workers in the Fangcang shelter hospitals and analyze potential risk factors associated with these symptoms, including PTSS, symptoms of anxiety, depression, insomnia, and perceived stress. Methods: This cross-sectional study used an online survey to assess mental health problems of 522 health care workers in a Jianghan Fangcang shelter from February 21 to February 28, 2020. Results: Overall, 25.3%, 25.3%, 51.0%, 58.0%, 14.8%, and 39.1% of all participants reported symptoms of posttraumatic stress, anxiety, depression, insomnia, and perceived stress, respectively. Multivariable logistic regression analysis showed that, occupation and technical title were associated with all investigated outcomes. Nurses were more likely to endorse posttraumatic stress symptoms (OR, 4.63; 95% CI, 2.43–8.82; p < .001), anxiety symptom (OR, 4.58; 95% CI, 2.76–7.62; p < .001), depression symptom (OR, 3.45; 95% CI, 2.17–5.64; p < .001). Participants with senior technical title were associated with higher perceived stress and insomnia than other technical title. Conclusion: In this survey, participants reported high rates of symptoms of posttraumatic stress, anxiety, depression, insomnia, and perceived stress. Combining with the special environment of the shelter hospitals and the psychological needs, the health care workers should be given more effective interventions to relieve their stress and improve mental symptoms.
Risk and protective factors for comorbidity of PTSD, depression, and anxiety among Somali refugees in Kenya
Authors: Im Hyojin , Swan Laura ET , Warsame Abdilkadir H , Isse Maimuna M 
Published: December 2020

Background: Comorbid common mental disorders (CMDs) are pervasive in refugee populations. However, limited research has explored psychosocial factors for mental disorder comorbidity in Somali refugee samples. Aims: This study aims to explore potential risk and protective factors for comorbid depression-anxiety and comorbid depression-PTSD by examining associations between trauma exposure, psychosocial factors, and mental health symptoms among a sample of Somali refugees displaced in urban Kenya. Methods: We used snowball sampling to recruit Somali youth aged 15 to 35years( N = 250, n = 143 female, n = 88 male, n = 19 unknown gender). We measured 16 common types of trauma exposure and three psychosocial factors (endorsing violence, willingness to share problems, and symptom awareness) and used the HSCL-25 and PCL-C to capture individual and comorbid CMD symptoms, using guided cutoff points and/or algorithms. We then ran a series of logistic regression analyses to examine relationships between trauma exposure, psychosocial factors, and individual and comorbid CMD symptoms. Results: Findings showed that increased trauma exposure predicted symptoms of individual and comorbid CMDs. Increased symptom awareness and endorsement of violence predicted comorbid depression-PTSD and comorbid anxiety-depression symptoms, respectively. Willingness to share problems buffered depressive symptoms but did not predict comorbidity. Conclusions: These findings revealed the high CMD comorbidity prevalence with differential effects of trauma and psychosocial factors on individual or comorbid mental disorders. This study suggests a need for transdiagnostic approaches that cut across Western diagnostic boundaries and consider culturally responsive and relevant items for mental health measures.
Phone-based outpatients’ follow-up in mental health centers during the COVID-19 quarantine
Authors: Gentile Alessandro , Torales Julio , O’Higgins Marcelo , Figueredo Pamela , Castaldelli-Maia Joao Mauricio , De Berardis Domenico , Petito Annamaria , Bellomo Antonello , Ventriglio Antonio 
Published: December 2020

Background: The current COVID-19 pandemic is affecting mental health of global population and, particularly, of people suffering from preexisting mental disorders. Aims: This study aims to report on findings from a phone-based clinical follow-up conducted in two large catchment areas in Italy and Paraguay, during the COVID-19 lockdown, in order to provide psychiatric assessments and measure the level of stress related to the quarantine in a large sample of psychiatric outpatients. Methods: A clinical phone-based follow-up has been conducted in two large catchment areas in the province of Chieti (Vasto, Italy) and City of Asunción (Paraguay), during the COVID-19 national lockdown. The following rating scales have been employed: Hamilton Anxiety Rating Scale (HAM-A); Hamilton Depression Rating Scale (HAM-D); 18-items Brief Psychiatric Rating Scale (BPRS-18). The psychological distress related to the outbreak has been assessed employing the Impact of Event Scale – Revised (IES-R). Results: A total of 110 outpatients were consecutively included and followed among those reporting a stable phase of illness before the COVID-19 lockdown. Findings confirmed a significant increase of general psychopathology, anxiety and fear as well as mild levels of stress related to the quarantine. Also, significant weight gain during the lockdown was detected among patients. Conclusions: This study confirmed the impact of COVID-19 lockdown on mental health of people suffering from psychiatric disorders and may also add evidence on the employment of digital psychiatry in the current pandemic.
High-stakes crisis management in the Low Countries: Comparing government responses to COVID-19
Authors: Pattyn Valérie , Matthys Joery , Hecke Steven Van 
Published: December 2020

Like many Western European countries, Belgium and the Netherlands have been strongly hit by COVID-19. Almost simultaneously, the virus spread, caused a relatively high number of infections and severe lockdown measures were imposed; however, at the same time, the crisis management response has been sufficiently different to justify a systematic comparative analysis. We start with the premise that decisions made on the basis of incomplete information show the true nature of governments’ response to a crisis, which is conditioned by legacies arising from the past and organizational cultures, existing and new governance structures, and strategies used by specific actors. We show that the difference in crisis management echoes the countries’ different types of consociationalism, though also that Belgian federalism and Dutch decentralism impeded a truly coherent response. The cost of coordinating different government levels made a uniform approach difficult too. Actor strategies attempting to exploit the crisis seem to have influenced the response the least but did have an impact on perceptions of the response. Points for practitioners The article unravels how the governments in the Low Countries responded to the COVID-19 challenge in the first half of 2020. It allows practitioners to better understand that under circumstances of an imminent crisis, specific governance structures matter. It also reveals that the cost of coordination between the federated and the federal level turned out to be quite high in Belgium. In the Netherlands, a lot of autonomy was left to federated and local authorities. This too impeded a more coherent approach. COVID-19 certainly offers possibilities for policymakers to exploit the crisis but opportunities are not always taken.
Performance assessment of free standing and building integrated grid connected photovoltaic system for southern part of India
Authors: Chandrika VS , Thalib M Mohamed , Karthick Alagar , Sathyamurthy Ravishankar , Manokar A Muthu , Subramaniam Umashankar , Stalin B 
Published: December 2020

Photovoltaic (PV) system efficiency depends on the geographical location and the orientation of the building. Until installing the building structures, the integration of the PV module must be evaluated with ventilation and without ventilation effects. This work optimises the performance of the 250 kWp grid-connected photovoltaic (GPV) for community buildings in the southern part of India. This simulation is carried out to evaluate the system efficiency of the GPV system under various ventilation conditions, such as free-standing PV (FSPV), building integrated photovoltaic ventilated (BIPV_V) and Building Integrated Photovoltaic without ventilation (BIPV). The PVsyst simulation tool is used to simulate and optimise the performance of the system with FSPV, BIPV and BIPV_V for the region of Chennai (13.2789° N, 80.2623° E), Tamilnadu, India. An annual system energy production is 446 MWh, 409 MWh and 428 MWh of FSPV, BIPV and BIPV_V system respectively. while electrical efficiency for the FSPV, BIPV_V, BIPV system is 15.45%. 15.25% and 14.75% respectively. Practical application: Integrating the grid connected photovoltaic system on the building reduces the energy consumption in the building. The integration of the PV on the roof or semi integrated on the roof is need to be investigated before installing on the buildings. The need for installation of the BIPV with ventilation is explored. This study will assist architects and wider community to design buildings roofs with GPV system which are more aesthetic and account for noise protection and thermal insulation in the region of equatorial climate zones.
Protocol for a Coordinated Approach for Building Capacity of Mental Health Researchers in India
Authors: Deshpande Smita N , Singh Ravinder , Bhatia Triptish , Shah Gyan D , Singh Harpreet , Hawk Mary , Nimgaonkar Vishwajit L 
Published: December 2020

Introduction: India’s National Mental Health Programme (NMHP) was initiated in 1982. In 2016, the Indian Council of Medical Research (ICMR) organized a Brainstorming Meeting on Prioritization of Mental Health Research. Recognizing the need for improving mental healthcare by building a cadre of mental health researchers based on focus areas of the NMHP, the ICMR organized a research training cum capacity building workshop in collaboration with the Cross-Fertilized Research Training Programme (funded by Fogarty International Centre, NIH, USA) in 2016. The workshop successfully prepared and reviewed 12 single and multicenter research proposals in priority areas of mental health research, which were awarded by the ICMR to middle- and junior-level research faculty and NGO. Methods: A National Coordination Unit (NCU) was set up to mentor investigators and to coordinate, train, and monitor the progress of their projects. Investigators were paired with senior mentors and also participated in four capacity building workshops focusing on proposal-writing, evaluation, and process tracking. Results: Following discussions with ICMR program officers, the NCU formulated standard operating procedures for ethical conduct, data collection, data sharing, progress reporting procedures, and manuscript preparation for all research projects. Regularly scheduled long-distance communications with investigators using social media and group communications were planned. NCU partnered with the ICMR Database Management Unit to build a shared online platform for real-time data entry and storage, and organized two project review meetings where it also coordinated with US faculty to organize public workshops on manuscript writing and qualitative research. Conclusions: The NCU will ensure timely completion of research projects, data entry and analysis, and reports and project publications. It is feasible to evaluate progress with the NMHP through coordinated multisite research that also enables research capacity building. Results from these projects will help in formulating policies by the Ministry of Health Government of India for achieving objectives of the NMHP.
Impact Evaluation of VKN–NIMHANS–ECHO Model of Capacity Building for Mental Health and Addiction: Methodology of Two Randomized Controlled Trials
Authors: Kumar Channaveerachari Naveen , Chand Prabhat Kumar , Manjunatha Narayana , Math Suresh Bada , Shashidhara Harihara Nagabhushana , Basavaraju Vinay , Thirthalli Jagadisha , Manjappa Adarsha Alur , Parthasarathy Rajani , Murthy Pratima , Ibrahim Ferose Azeez , Jagtap Namrata , Jyrwa Sonakshi , Reddy Shanivaram , Arora Sanjeev , Hawk Mary , Kumar Supriya , Egan James , Mcdonald Margaret 
Published: December 2020

Background: Bridging the alarming treatment gap for mental disorders in India requires a monumental effort from all stakeholders. Harnessing digital technology is one of the potential ways to leapfrog many known barriers for capacity building. Aim and Context: The ongoing Virtual Knowledge Network (VKN)–National Institute of Mental Health and Neurosciences (NIMHANS)–Extension of Community Health Outcomes (ECHO) (VKN–NIMHANS–ECHO: hub and spokes model) model for skilled capacity building is a collaborative effort between NIMHANS and the University of New Mexico Health Sciences Centre, USA. This article aims to summarize the methodology of two randomized controlled trials funded by the Indian Council of Medical Research (ICMR) designed to evaluate the effectiveness of the VKN–NIMHANS–ECHO model of training as compared to training as usual (TAU). Methods: Both RCTs were conducted in Karnataka, a southern Indian state in which the DMHP operates in all districts. We compared the impact of the following two models of capacity building for the DMHP workforce (a) the VKN–NIMHANS–ECHO model and (b) the traditional method. We use the SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) statement to describe the methods of these two trials. Trial 1 is to evaluate the “Effectiveness of addition of Virtual-NIMHANS–ECHO tele-mentoring model for skilled capacity building in providing quality care in alcohol use disorders by the existing staff of DMHP districts of Karnataka.” Hub for trial 1 was set up at NIMHANS and the spokes were psychiatrists and other mental health professionals headquartered in the district level office. Trial 2 assesses the implementation and evaluation of the NIMHANS–ECHO blended training program for the DMHP workforce in a rural south-Indian district of Karnataka state. The hub for trial 2 was set up in the district headquarter of Ramanagaram. Hub specialists are DMHP psychiatrists, whereas spokes are the non-doctor workforce (including auxiliary nurse midwives [ANMs] and accredited social health activists [ASHA] workers) medical officers of primary health centers. The location of the HubHub differs in these two studies. Both trials are funded by the ICMR, Government of India Discussion: Both these trials, though conceptually similar, have some operational differences which have been highlighted. If demonstrated to be effective, this model of telementoring can be generalized and widely merged into the Indian health care system, thus aiding in reducing the treatment gap for patients unable to access care.
Remote ischemic preconditioning effects on inflammatory markers and myocardial protection in coronary artery bypass graft surgery
Authors: Gorjipour Farhad , Saeedzadeh Tahereh , Toloueitabar Yaser , Kachoueian Naser , Bahlouli Ghashghaei Sepideh , Mortazian Meysam , Dehghani Firoozabadi Mehdi , Jadbabaie Amirnaser , Tirgarfakheri Koroush , Motamednejad Amir , Totonchi Ziae 
Published: December 2020

Background: Induction of short episodes of ischemia to remote organs, namely upper or lower limbs, literally known as remote ischemic preconditioning (RIPC) has been suggested as a preconditioning approach to ameliorate ischemia/reperfusion injury (IRI). RIPC has been demonstrated to effectively protect various vital organs, including heart, against the next ischemic events in preclinical studies. However, human studies are required to approve its clinical applicability. Present study was performed to evaluate the effect of RIPC on the myocardial protection and inflammatory response markers in patients undergoing coronary artery bypass graft surgery Methods: In this randomized clinical trial, 43 coronary artery bypass graft (CABG) patients from Imam Hossein educational hospital were allocated in two groups, RIPC (21 patients) and control (22 patients). Serum level of interleukin (IL)-4, IL-8, and IL-10, interferon (IFN)-γ and Cardiac Troponin-I (cTnI) were measured in (1) after induction of anesthesia (before incision of skin), (2) after separation from CPB and (3) 24 hours after ICU arrival. Results: increase pack cell transfusions were observed in control group in ICU. Serum level of IL-10 at 24 hours after ICU admission was significantly higher in the RIPC group. Significantly lower amounts of IL-8 at post-CPB time were observed in the RIPC group in comparison with control. Conclusion: RIPC regulates the circulatory inflammatory cytokines, IL-8 decrement and IL-10 elevation, which could be translated into protection against IRI. However, further studies with larger sample sizes with careful consideration of parameters such as use of propofol as an anesthetic in the patients should be conducted to consolidate the findings from the current study.
Knockdown of Forkhead box A1 suppresses the tumorigenesis and progression of human colon cancer cells through regulating the phosphatase and tensin homolog/Akt pathway
Authors: Pan Jie , Xu Zongbin , Xu Meifang , Lin Xiaoyan , Lin Bingqiang , Lin Mengxin 
Published: December 2020

Background This study aimed to evaluate the role and the underlying mechanisms of Forkhead box A1 (encoded by FOXA1) in colon cancer. Methods We analyzed FOXA1 mRNA and protein expression in colon cancer tissues and cell lines. We also silenced FOXA1 expression in HCT116 and SW480 cells to evaluate the effects on cell proliferation, cell cycle, migration, and invasion by using MTT, colony formation, flow cytometry, and the Transwell assay, respectively. Results FOXA1 immunostaining was higher in colon cancer tissues than adjacent healthy tissues. FOXA1 mRNA and protein expression was significantly increased in human colon cancer cells compared with a normal colonic cell line. FOXA1 expression was also significantly higher in colorectal cancer tissues from TCGA data sets and was associated with worse prognosis in the R2 database. FOXA1 expression was negatively correlated with the extent of its methylation, and its knockdown reduced proliferation, migration, and invasion, and induced G2/M phase arrest in HCT116 and SW480 cells by suppressing the phosphatase and tensin homolog/Akt signaling pathway and inhibiting epithelial–mesenchymal transition. Conclusion FOXA1 may act as an oncogene in colon cancer tumorigenesis and development.
Sociodemographic and clinical characteristics of patients with recurrent psychiatric readmissions in Qatar
Authors: Elhassan Nahid M. , Elhusein Bushra , Al Abdulla Majid , Saad Tarek Abdelhalim , Kumar Rajeev 
Published: December 2020

Objective To examine the sociodemographic and clinical characteristics of psychiatric patients with recurrent psychiatric readmissions (RPR). Methods A retrospective study was conducted at Hamad General Hospital in Qatar on psychiatric patients with recurrent readmissions from August 2018 to January 2019. Results Of 380 psychiatric patients admitted during the study period, 40 (10.5%) were readmitted within 30 days of discharge. Most of the patients who were readmitted were single, male and unemployed. Psychotic spectrum disorder was the most frequent psychiatric condition and was diagnosed in 18 (45%) patients. A total of 30% of the patients were receiving treatment with anti-psychotics, and a similar number received more than one medication. Most patients showed poor or no compliance. Only 12.5% of patients stayed in the hospital for more than 5 weeks in their last admission during the study period. Conclusions Poor compliance, male sex and single status were the most common demographic and clinical features of patients with RPR. Post-discharge psychiatric care should be tailored to meet the requirements of patients prone to RPR.
Home-based exercise is associated with improved cardiac functional performance in patients after acute myocardial infarction
Authors: Ma Liqun , Xiong Xiaowei , Yan Lihui , Qu Jie , Hujie Gulibaha , Ma Yunjuan , Ren Jun , Ma Jianxin 
Published: December 2020

Objective To evaluate the effects of home-based exercise and physical activity on cardiac functional performance in patients after acute myocardial infarction (MI) during the coronavirus disease 2019 (COVID-19) pandemic. Methods This retrospective study enrolled patients that received treatment of acute ST-segment elevation MI between and were followed-up 6 months later. The patients were divided into physically active and inactive groups based on their levels of home exercise after hospital discharge. Results A total of 78 patients were enrolled in the study: 32 were physically active and 46 were physically inactive. The baseline characteristics were comparable between the two groups. At the 6-month visit, left ventricular ejection fraction and six-minute walking test (6MWT) were significantly improved while the proportion of patients with a New York Heart Association (NYHA) functional III classification was decreased in the active patients, whereas these parameters were not significantly changed in the inactive patients. In addition, the 6MWT was greater while the proportion of patients with an NYHA III classification was lower in the active group than the inactive group at the 6-month visit. Conclusion Maintaining physical activity at home was associated with improved cardiac functional performance in patients after acute MI during the COVID-19 pandemic.
Prolonged benefit from palbociclib plus letrozole in heavily pretreated advanced male breast cancer: case report
Authors: Zattarin Emma , Ligorio Francesca , Nichetti Federico , Bianchi Giulia , Capri Giuseppe , de Braud Filippo 
Published: December 2020

Introduction: Breast cancer in men is less common than in women and treatment recommendations are often derived from clinical trials exclusively involving women. Data on efficacy of CDK 4/6 inhibitors, which are the mainstay of treatment for hormone receptor–positive/HER2-negative advanced breast cancer, are lacking in male patients. Case report: We present a clinical case of prolonged benefit from palbociclib in combination with letrozole and LHRH analogue in a man who had previously been treated with six lines of endocrine therapies and chemotherapy regimens but was still in excellent clinical condition. Conclusions: This clinical case demonstrates that male breast cancer stands out as an endocrine-sensitive disease, which could potentially benefit from CDK 4/6 inhibitors in combination with endocrine agents even in very heavily pretreated settings of disease, underscoring both the importance of an accurate selection of patients for later treatment lines, taking into account disease history and previous treatment responses, and the peculiarity of breast cancer in men, which deserves dedicated clinical trials to tailor future recommendations.
Management and complete resection of peritoneal and bone metastases from mucinous rectal carcinoma
Authors: Milito Pamela , Battaglia Luigi , Cosimelli Maurizio , Antista Maria , Guaglio Marcello , Deraco Marcello , Baratti Dario 
Published: December 2020

Introduction: Surgical management of patients with multiple metastases from mucinous rectal carcinoma is feasible. Case description: We present a case of a 66-year-old woman with a late onset of peritoneal and coccygeal metastasis from a mucinous rectal carcinoma treated with cytoreductive surgery. After 30 months from rectal resection, the patient underwent exploratory laparotomy with resection of all tumor localizations by means of pelvic peritonectomy, complete supracolic omentectomy, jejuneal resection, appendectomy, and excision of the mobile part of the coccyx. Conclusion: This report aims to point out the atypical late-onset recurrence presentation and management of a mucinous carcinoma of the rectum.