bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Social Media Addiction on Quality of Sleep among University Students: Gender and Socio-Economic Status are in Focus
Authors: Khan Aqeel Ahmad , Sajjad Muhammad , Iqbal Ammara 
Published: December 2024

The current research was designed to elucidate the impact of frequent use of social media addiction on the quality of sleep-in relation with gender, age and the socio-economic status among university students. For that purpose, a sample of (N=203) students was recruited by using purposive sampling technique. The overall study was quantitative and cross-section research design was used to carry out the study. Two scales were administered to quantify the variables under investigation. The level of social media addiction was measured by using Social Media Addiction Scale (2015) by Tutgun and Deniz and Quality of Sleep was measured by using Sleep Quality Scale by Shin et al (2006). Both of the measures were valid and reliable. The results from the collected data were analyzed by using SPSS. The findings of the study revealed that the overall social media addiction level was higher among female students as compared with male students. Similarly, the quality of sleep was disturbed among female social media addicts. Lastly, the results showed that the individuals belonging upper class were more addict of social media and their quality of sleep was also disturbed. On the basis of the results, this revealed that the social media addition is a silent killer of sleep among the female and upper-class individuals. Hence, it concluded that to improve the sleep quality it is necessary to control the excessive use of social media addiction.
Rammedelegation i almen praksis til akutsygeplejen. Hvad betyder det for indlæggelser i akutafdelingen ?
Authors: Friesgaard Christensen Anne , Larsen Marianne Britt , Strunge Jonas 
Published: December 2024

Crowding er et stort problem i akutmodtagelser verden over. Problemet er komplekst og multifaktorielt. Ofte koncentrer vi os om akutmodtagelsernes througput og output for at løse problemet, men en stor del af de patienter som indlægges (input), indlægges unødigt. I projektet ønskede vi at undersøge, hvorvidt en ændret arbejdsgang , hvor de praktiserende læger i en kommune gav akutsygeplejersker rammedelegation til udvidet blodprøvetagning i form af hæmoglobin, væske -og infektionstal, ville have betydning for antallet af unøde indlæggelser fra kommunen. Akutmodtagelsens speciallæger etablerede hotline så både praksis og akutsygepleje kunne få råd og vejledning ved behov. I alt 135 patienter fik gennem 6 måneder besøg af akutsygeplejen med blodprøveudstyret, hvoraf ca. 50 procent var ordineret af egen læge. Efter sygeplejevurdering og blodprøver blev 39 procent behandlet i eget hjem, 17 procent blev indlagt, og hos 38 procent fik besøget ingen konsekvens. Akutsygeplejen vurderede i op til 44 procent af tilfældene at en indlæggelse var undgået. For at validere resultaterne kunne akutmodtagelsen se, at andelen af indlæggelser fra den pågældende kommune på 2 år var reduceret med ca 30 procent sammelignet med de øvrige optageområdekommuner og genindlæggelsesraten faldet med 61 procent.
Den beskrevne enkle arbejdsgangsændring i en kommune i tæt samarbejde med almen praksis medførte et stort fald i andelen af indlæggelser fra kommunen sammenlignet med det samlede optageområde og et fald i genindlæggelsesraten. Udbredelsen af initiativet vil have stor betydning i forhold til at hindre unødige indlæggelser og dermed reducere risikoen for crowding.
Usage of biomarker S100B to avoid CT after low-risk, mild head trauma: a single center clinical review of the Scandinavian head trauma guideline and guideline adherence
Authors: Jensen Louise Cecilie , Gharai-Moghadam Neusha , Revsholm Jesper , Posth Stefan , Krone Willy Altinok , Graumann Ole , Junker Theresa 
Published: December 2024

Resume
Baggrund I 2013 publicerede Scandinavian Neurotrauma Comittee (SNC) en ny retningslinje til håndtering af minimale, milde og moderate hovedtraumer. Retningslinjen inkluderede brugen af biomarkøren S100B til opsporing af patienter med behov for yderligere intervention, herunder computed tomography af cerebrum (CT-C).
Formål Formålet med studiet er at undersøge brugen af S100B i forhold til retningslinjen fra SNC, herunder compliance af guideline.
Metode Dette retrospektive kohortestudie var baseret på data fra alle S100B blodprøver taget i perioden 1 marts 2022 til 1 marts 2023 i en Dansk Akutmodtagelse.
Resultat I alt blev blodprøver fra 236 patientjournaler inkluderet og kategoriseret ifølge SNC’s hovedtraumekategorier. Retningslinjen blev fulgt ved 152 af patientforløbene (64,4%). Det var hovedsageligt hos patienter med minimale og lav-risiko milde hovedtraumer, hvor brud på retningslinjen blev registreret. Årsagerne til manglende compliance var unødvendig rekvirering af S100B blodprøven, for sen blodprøvetagning, manglende eller unødvendige CT-C’er.
Konklusion Retningslinje compliance var generelt udfordret, hvilket udgjorde en væsentlig del af resultaterne. For at kunne forbedre compliance er der behov for fremtidige studier, som kan klarlægge de forskellige årsager.
Abstract
Background In 2013, the Scandinavian Neurotrauma Committee (SNC) published a new guideline for managing minimal, mild and moderate head trauma. The guideline included the use of biomarker S100B to identify patients needing a head computed tomography (CT), among others.
Purpose To explore the use of S100B in relation to the SNC guideline, including guideline adherence.
Material and methods In this retrospective cohort study, data was collected for all consecutive S100B blood samples drawn in a Danish Emergency Department between March 1, 2022, and March 1, 2023
Results A total of 236 patient cases were included and categorized according to SNC head trauma categories. Guideline adherence was achieved for 152 patient cases (64.4%). Non-adherence (35.6%) was mainly seen in the minimal and low-risk, mild head trauma categories. The reasons for non-adherence were excessive S100B blood sampling, late blood sampling, and missing and excessive head CTs.
Conclusion Guideline adherence was generally challenged and non-adherence was a substantial part of the results. Further studies are needed to explore reasons for non-adherence, and tools to improve guideline adherence.
Development Strategy for Village Owned Enterprises: A Case Study in Majalengka Regency, West Jawa Province, Indonesia
Authors: Sulaksana Jaka , Dwirayani Dina 
Published: December 2024

Village-Owned organizations (BUMDes) are one of the strategic units in empowering village communities. South Maja BUMDes is one of the BUMDes which has several commercial enterprise units inside it and up to now, it has survived. This studies objectives to determine the internal and outside factors of BUMDes South Maja and to decide the strategic priorities that want to be taken for BUMDes development. The research technique used became quantitative descriptive research via taking 33 respondents. The evaluation finished is a SWOT analysis preceded with the aid of an hobby degree analysis. The effects of the IFE matrix analysis are the primary power in control which does now not involve many human beings, making operations and choice making easier. meanwhile, the principle weak spot is that there may be no era that can facilitate communique among administrators, managers and consumers. The outcomes of the IE matrix show that BUMDes South Maja is in cellular or box which has function presents an outline of the country of BUMDes South Maja which is in a maintain and maintain circumstance.
Harnessing the immune system after allogeneic stem cell transplant in acute myeloid leukemia
Authors: Sterling Cole , Webster Jonathan 
Published: February 2020

AbstractAllogeneic stem cell transplantation (allo‐SCT) is the most successful and widely used immunotherapy for the treatment of acute myeloid leukemia (AML), as a result of its anti‐leukemic properties driven by T cells and natural killer (NK) cells, leading to a graft‐vs‐leukemia (GVL) effect. Despite its essential role in AML treatment, relapse after allo‐SCT is common and associated with a poor prognosis. There is longstanding interest in developing immunologic strategies to augment the GVL effect post‐transplant to prevent relapse and improve outcomes. In addition to prophylactic maintenance strategies, the GVL effect can also be used in relapsed patients to reinduce remission. While immune checkpoint inhibitors and other novel immune‐targeted agents have been successfully used in the post‐transplant setting to augment the GVL effect and induce remission in small clinical trials of relapsed patients, exacerbations of graft‐vs‐host disease (GVHD) have limited their broader use. Here we review advances in three areas of immunotherapy that have been studied in post‐transplant AML: donor lymphocyte infusion (DLI), immune checkpoint inhibitors, and other monoclonal antibodies (mAbs), including antibody‐drug conjugates (ADCs) and ligand receptor antagonists. We also discuss additional therapies with proposed immunologic mechanisms, such as hypomethylating agents, histone deacetylase inhibitors, and the FLT3 inhibitor sorafenib.
Comorbidity of congenital heart defects and holoprosencephaly is likely genetically driven and gene‐specific
Authors: Tekendo‐Ngongang Cedrik , Owosela Babajide , Muenke Maximilian , Kruszka Paul 
Published: February 2020

AbstractComorbidity of holoprosencephaly (HPE) and congenital heart disease (CHD) in individuals with genetic variants in known HPE‐related genes has been recurrently observed. Morphogenesis of the brain and heart from very early stages are regulated by several biological pathways, some of them involved in both heart and brain development as evidenced by genetic studies on model organisms. For instance, downregulation of Hedgehog or Nodal signaling pathways, both known as major triggers of HPE, has been shown to play a role in the pathogenesis of CHD, including structural defects and left–right asymmetry defects. In this study, individuals with various types of HPE were investigated clinically and by genomic sequencing. Cardiac phenotypes were assessed in 434 individuals with HPE who underwent targeted sequencing. CHDs were identified in 8% (n = 33) of individuals, including 10 (30%) cases of complex heart disease. Only four individuals (4/33) had damaging variants in the known HPE genes STAG2, SIX3, and SHH. Interestingly, no CHD was identified in the 37 individuals of our cohort with pathogenic variants in ZIC2. These findings suggest that CHD occurs more frequently in HPE‐affected individuals with or without identifiable genetic variants, and this co‐occurrence may be genetically driven and gene‐specific.
Protection Strategies Enable Selective Conversion of Biomass
Authors: Luo Xiaolin , Li Yanding , Gupta Navneet Kumar , Sels Bert , Ralph John , Shuai Li 
Published: February 2020

AbstractSelective and economic conversion of lignocellulosic biomass components to bio‐based fuels and chemicals is the major goal of biorefineries, but low yields and selectivity for fuel precursors such as sugars, furanics, and lignin‐derived monomers pose significant disadvantages in process economics. In this Minireview we summarize the existing protection strategies used in biomass chemocatalytic conversion processes and focus the discussions on the mechanisms, challenges, and opportunities of each strategy. We introduce a concept of using analogous methods to manipulate biomass catalytic conversion pathways during the upgrading of carbohydrates to fuels and chemicals. This Minireview may provide new insights into the development of selective biorefining processes from a different perspective, expanding the options for selective conversion of biomass to fuels and chemicals.
Fabrication of Microporous Metal–Organic Frameworks in Uninterrupted Mesoporous Tunnels: Hierarchical Structure for Efficient Trypsin Immobilization and Stabilization
Authors: Lu Jie , Wu Ju‐Kang , Jiang Yao , Tan Peng , Zhang Lin , Lei Yu , Liu Xiao‐Qin , Sun Lin‐Bing 
Published: February 2020

AbstractHierarchically porous metal–organic frameworks (HP‐MOFs) are promising in various applications. Most reported HP‐MOFs are prepared based on the generation of mesopores in microporous frameworks, and the formed mesopores are connected by microporous channels, limiting the accessibility of mesopores for bulky molecules. A hierarchical structure is formed by constructing microporous MOFs in uninterrupted mesoporous tunnels. Using the confined space in as‐prepared mesoporous silica, highly dispersed metal precursors for MOFs are coated on the internal surface of mesoporous tunnels. Ligand vapor‐induced crystallization is employed to enable quantitative formation of MOFs in situ, in which sublimated ligands diffuse into mesoporous tunnels and react with metal precursors. The obtained hierarchically porous composites exhibit record‐high adsorption capacity for the bulky molecule trypsin. The thermal and storage stability of trypsin is improved upon immobilization on the composites.
Nickel‐Catalyzed Chain‐Walking Cross‐Electrophile Coupling of Alkyl and Aryl Halides and Olefin Hydroarylation Enabled by Electrochemical Reduction
Authors: Kumar Gadde Sathish , Peshkov Anatoly , Brzozowska Aleksandra , Nikolaienko Pavlo , Zhu Chen , Rueping Magnus 
Published: February 2020

AbstractThe first electrochemical approach for nickel‐catalyzed cross‐electrophile coupling was developed. This method provides a novel route to 1,1‐diarylalkane derivatives from simple and readily available alkyl and aryl halides in good yields and excellent regioselectivity under mild conditions. The procedure shows good tolerance for a broad variety of functional groups and both primary and secondary alkyl halides can be used. Furthermore, the reaction was successfully scaled up to the multigram scale, thus indicating potential for industrial application. Mechanistic investigation suggested the formation of a nickel hydride in the electroreductive chain‐walking arylation, which led to the development of a new nickel‐catalyzed hydroarylation of styrenes to provide a series of 1,1‐diaryl alkanes in good yields under mild reaction conditions.
Enabling a Durable Electrochemical Interface via an Artificial Amorphous Cathode Electrolyte Interphase for Hybrid Solid/Liquid Lithium‐Metal Batteries
Authors: Liang Jia‐Yan , Zhang Xu‐Dong , Zeng Xian‐Xiang , Yan Min , Yin Ya‐Xia , Xin Sen , Wang Wen‐Peng , Wu Xiong‐Wei , Shi Ji‐Lei , Wan Li‐Jun , Guo Yu‐Guo 
Published: February 2020

AbstractA hybrid solid/liquid electrolyte with superior security facilitates the implementation of high‐energy‐density storage devices, but it suffers from inferior chemical compatibility with cathodes. Herein, an optimal lithium difluoro(oxalato)borate salt was introduced to build in situ an amorphous cathode electrolyte interphase (CEI) between Ni‐rich cathodes and hybrid electrolyte. The CEI preserves the surface structure with high compatibility, leading to enhanced interfacial stability. Meanwhile, the space‐charge layer can be prominently mitigated at the solid/solid interface via harmonized chemical potentials, acquiring promoted interfacial dynamics as revealed by COMSOL simulation. Consequently, the amorphous CEI integrates the bifunctionality to provide an excellent cycling stability, high Coulombic efficiency, and favorable rate capability in high‐voltage Li‐metal batteries, innovating the design philosophy of functional CEI strategy for future high‐energy‐density batteries.
Spatially Controlled Supramolecular Polymerization of Peptide Nanotubes by Microfluidics
Authors: Méndez‐Ardoy Alejandro , Bayón‐Fernández Alfonso , Yu Ziyi , Abell Chris , Granja Juan R. , Montenegro Javier 
Published: February 2020

AbstractDespite the importance of spatially resolved self‐assembly for molecular machines, the spatial control of supramolecular polymerization with synthetic monomers had not been experimentally established. Now, a microfluidic‐regulated tandem process of supramolecular polymerization and droplet encapsulation is used to control the position of self‐assembled microfibrillar bundles of cyclic peptide nanotubes in water droplets. This method allows the precise preferential localization of fibers either at the interface or into the core of the droplets. UV absorbance, circular dichroism and fluorescence microscopy indicated that the microfluidic control of the stimuli (changes in pH or ionic strength) can be employed to adjust the packing degree and the spatial position of microfibrillar bundles of cyclic peptide nanotubes. Additionally, this spatially organized supramolecular polymerization of peptide nanotubes was applied in the assembly of highly ordered two‐dimensional droplet networks.
Formation and Characterization of a BeOBeC Multiple Radical Featuring a Quartet Carbyne Moiety
Authors: Li Wan‐Lu , Zhang Qingnan , Chen Mohua , Hu Han‐Shi , Li Jun , Zhou Mingfei 
Published: February 2020

AbstractThrough reaction of beryllium dimers with carbon monoxide, a carbonyl complex BeBeCO is formed in solid neon. Upon visible light excitation, the BeBeCO complex rearranges to a BeCOBe isomer, which further isomerizes to a low‐energy BeOBeC species under UV‐visible light excitation. These species are identified on the basis of infrared absorption spectroscopy with isotopic substitutions and quantum chemical studies. The BeOBeC molecule is characterized to be a multiple radical species having an electronic quintet ground state featuring an unusual quartet carbyne unit with three unpaired electrons on the carbon center. Bonding analysis indicates that the strong Pauli repulsion between carbon 2s lone pair electrons and the σ electrons of the BeOBe fragment significantly weakens the Be−C bonding and destabilizes the triplet state of the BeOBeC radical with a doublet carbyne unit. The three‐center π‐bonding of BeOBe is also found to play a role in stabilizing the quartet carbyne.
Two‐Dimensional Nanomaterials for Photothermal Therapy
Authors: Liu Shuang , Pan Xueting , Liu Huiyu 
Published: February 2020

AbstractTwo‐dimensional (2D) nanomaterials are currently explored as novel photothermal agents because of their ultrathin structure, high specific surface area, and unique optoelectronic properties. In addition to single photothermal therapy (PTT), 2D nanomaterials have demonstrated significant potential in PTT‐based synergistic therapies. In this Minireview, we summarize the recent progress in 2D nanomaterials for enhanced photothermal cancer therapy over the last five years. Their unique optical properties, typical synthesis methods, and surface modification are also covered. Emphasis is placed on their PTT and PTT‐synergized chemotherapy, photodynamic therapy, and immunotherapy. The major challenges of 2D photothermal agents are addressed and the promising prospects are also presented.
Thermoformable high oxygen barrier multilayer EVOH/LDPE film/foam
Authors: Souza Claudio , Feng Jingxing , Olah Andrew , Wnek Gary , Baer Eric 
Published: February 2020

ABSTRACTThe effect of the number of layers on oxygen transmission and thermoformability of novel multilayer film/foam materials was investigated. Ethylene‐vinyl alcohol copolymer/low‐density polyethylene multilayered film/foam composites having 16, 32, and 64 alternating layers were developed using continuous multilayer coextrusion process, and the morphology, density, oxygen transmission, and mechanical properties of the as‐extruded film/foams were characterized. Tensile properties of the film/foams at elevated temperatures were used to optimize thermoforming conditions. Uniaxial orientation was discovered as an efficient approach to evaluate the potential for thermoforming. Oxygen transmission showed a strong correlation with the thickness reduction which could be used as an indicator for barrier properties of the packaging materials. Film/foam materials with 32 layers demonstrated optimum performance with low oxygen transmission along with high drawing capability. © 2020 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48903.
pH‐Dependent thermoresponsive poly[2‐(diethylamino)ethyl acrylamide]‐grafted PVDF membranes with switchable wettability for efficient emulsion separation
Authors: Xian Yupei , Shui Yonggang , Li Meimei , Pei Cunbao , Zhang Qiyi , Yao Yongyi 
Published: February 2020

AbstractPlenty of oily wastewater discharged from industrial and domestic sewage has deteriorated the environment severely, so stimuli‐responsive membranes with switchable wettability have been of considerable attraction for its potential application in oil/water separation. In this work, a novel pH‐dependent thermoresponsive membrane fabricated by grafting the poly[2‐(diethylamino)ethyl acrylamide] (PDEAEAM) from the poly(vinylidene fluoride) (PVDF) membrane via surface‐initiated atom transfer radical polymerization is explored to achieve the oil/water separation. The PDEAEAM‐g‐PVDF membrane shows hydrophilicity at room temperature under neutral condition while hydrophobicity at 50°C under alkaline condition. Wettability of the membrane at different temperatures is dominated by the lower critical solution temperature (LCST) of PDEAEAM, and the LCST of PDEAEAM is pH dependent. Due to the LCST of PDEAEAM, the membrane shows a variation of separation efficiency for separating hexadecane/water emulsion with temperature and pH. Typical separation efficiencies are 97.10% at 25°C under neutral condition and 30.26% at 50°C under alkaline condition.
Effect of Pluronic F127 on the 3D pore morphology of poly(N‐isopropylacrylamide‐co‐acrylic acid) hydrogels and their nitric oxide release from S‐nitrosoglutathione
Authors: Cabrini Flávia Mesquita , Champeau Mathilde , de Oliveira Marcelo Ganzarolli 
Published: February 2020

AbstractChanging the pore morphology of hydrogels can be an effective strategy to modulate their drug release profiles. Herein, Pluronic F127 was used to change the three‐dimensional pore morphology of crosslinked poly(N‐isopropylacrylamide‐co‐acrylic acid) (P[NIPAm‐co‐AAc]) hydrogels. F127 reduced the pore diameters from 20 ± 4 to 2.9 ± 0.4 μm and from 11 ± 1 to 1.4 ± 0.4 μm in hydrogels synthesized at 8 and 30°C, respectively. Small‐angle X‐ray scattering indicates that the segregation of the F127 during the polymerization process induces F127 phase transitions from unimers (at 8°C) or cubic‐packed micelles (at 30°C) to a lamellar structure. P(NIPAm‐co‐AAc) hydrogels charged with S‐nitrosoglutathione (GSNO), released nitric oxide (NO) spontaneously during hydration. The decrease in the pore diameter led to a twofold to threefold increase in the rate of water absorption and a fourfold to sixfold increase in the rate of NO release of the hydrogels. F127 can be used to change the pore morphology of P(NIPAm‐co‐AAc) hydrogels, with concomitant changes in their rate of hydration and NO release from GSNO, opening a new perspective for their use in topical NO delivery.