bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of the perinatal and thoracic periods in children with autism spectrum disorders
Authors: Bavykina I. A. , Zvyagin A. A. , Ledneva V. S. , Ivannikova A. S. , Yurova I. Yu. 
Published: December 2024

Background. Autism spectrum disorders are a pathology that is becoming increasingly widespread throughout the world, regardless of geographic, climatic, socioeconomic or other regional characteristics. Due to the wide spread of this pathology, early detection of disease predictors is of great importance. Competent observation by a local pediatrician in the first year of life is of great importance in the first determination of disease symptoms / identification of risk groups. However, clear predictors indicating the presence of pathology have not been developed due to the lack of an accurate understanding of the etiology, pathogenesis of autism and the diversity of the clinical signs. It is believed that the gastrointestinal tract, microbiota, food intolerance play a certain role in the development and severity of ASD, but further research is needed in this area.Materials and methods. The study included 138 children with autism spectrum disorders aged 3–15 years (Me 6 [4; 7.5]) and their parents. There were 91 boys and 47 girls. A thorough analysis of the obstetric history, the course of the intranatal and neonatal periods, the nature of feeding, the neuropsychic development of children in the first year of life, and the social and everyday aspects of family life was carried out. Statistical analysis was performed using descriptive statistics methods.Results. The perinatal period of children with autism spectrum disorders does not differ significantly from the average data in the population. It was found that the assessment of emotional development is of great importance in monitoring children in the first year of life. Despite the fact that the examined patients did not have a clinically significant delay in neuropsychic development (more than 2 epicrisis periods), it is nevertheless noted that motor development was impaired less often than emotional, play and speech skills.Conclusions. Perinatal, social factors, the nature of feeding and past diseases do not affect the development of the disease. Among the assessment criteria in infancy, special attention should be paid to neuropsychic development, in particular emotional development and play activities.
Clinical case of infiltrative pulmonary tuberculosis complicated by bronchal tuberculosis in a child
Authors: Afanasyev E. I. , Mymrina A. Yu. , Nabiullina Z. R. , Buzanakova T. V. 
Published: December 2024

Introduction. Infiltrative pulmonary tuberculosis is a localized form of tuberculosis, in some cases preceding more common and prognostically unfavorable forms of tuberculosis. With this disease, there are no absolute specific signs in the clinical and radiological picture, which makes differential diagnosis difficult. Thus, the time to verify the diagnosis is lengthened, which leads to the development of complications. Bronchial tuberculosis is a specific inflammatory lesion of the bronchial wall caused by M. tuberculosis and usually complicating the course of tuberculosis of the intrathoracic lymph nodes (TIHLN) and lungs [1]. As an independent form, this disease is rare. More often it is complicated by the course of destructive forms of pulmonary tuberculosis, tuberculous bronchoadenitis and primary tuberculosis complex.Target. To analyze a clinical case of a complicated form of pulmonary tuberculosis in a child.Materials and methods. The article used an analytical method based on data copied from the medical record of a child who was being treated at the Republican Clinical Tuberculosis Hospital (RKTB MZ UR). Results. Adequately prescribed therapy helped prevent further progression of the disease.Conclusion. The clinical example presented in the article is one of the confirmations that planned annual diagnostic measures still remain relevant for the timely diagnosis of various diseases.
Complex application of СО2 laser and tranexamic acid in the treatment of melasma in postmenopausal women (literature review)
Authors: Sharova A. A. , Logacheva N. S. 
Published: December 2024

Melasma is a common acquired pigmentation disorder, represented by patches of light brown or brown color localized on areas of the skin exposed to prolonged sunlight. The increased activity of melanocytes, which underlies the pathogenesis of melasma, is due to genetic predisposition, chronic insolation and hormonal imbalance. In postmenopausal women, the increased severity of melasma is associated with a combination of these factors. In addition, pigmentation disorders may be affected by taking certain medications and other environmental factors. There are many methods of treating melasma, including the use of topical remedies, chemical peels, laser therapy and others. In recent years, more and more attention has been paid to an integrated approach that combines various treatment methods to achieve the best result. One of the effective methods of treating this pathology is the use of a CO2 laser. However, many patients relapse after laser treatment. In this regard, there has been interest in the combined use of laser therapy using topical agents that reduce the severity of pigmentation. One of these drugs is tranexamic acid, which has the property of reducing the activity of melanocytes.The purpose of this literature review is to study the latest publications on the treatment of melasma using laser-associated administration of tranexamic acid.Material and methods. The literature data on search words – melasma, hyperpigmentation, tranexamic acid, CO2 laser, fractional grinding, laser-associated administration, postmenopause in computer databases PubMed, Elibrary, Cochrane Library, Medscape were studied. Web of Science, Scopus. Publications included basic scientific research, randomized controlled trials, comments and reviews. The results of clinical improvement were assessed by the MASI melasma area and severity index, as well as the modified mMASI index.
Possibilities of remote monitoring to manage skin toxicity in oncology patients
Authors: Gabrielian G. A. , Sekacheva M. I. , Orlova E. V. , Torchinsky N. V. 
Published: December 2024

Purpose. Analysis of the effectiveness of remote monitoring in the management of skin toxicity in oncology patients.Materials and methods. A comparative study of 2 cohorts of oncology patients with skin toxicity receiving supportive care through remote monitoring using the PSP “Healthy Skin” and outpatient consultations. Nonparametric statistical methods were used with a significance level of p<0.05.Results. A comparative analysis of 150 patients divided into 2 equal groups showed the effectiveness of using the remote monitoring (group 1) in the form of a reliable decrease in median BSA (%) by 67 %, 5D itching scale by 65 %, DLQI by 70 % compared to 10 %, 22 %, 20 % in group 2, respectively, over 4 weeks of the study. In group 2, deterioration of the skin condition was noted in 13.3 % of patients, 9 % of patients underwent a reduction in the dose of the anticancer therapy, 5 % had a break, while in group 1 such episodes were not noted due to the stability of the condition. Positive dynamics in the form of a decrease in the severity of skin toxicity was noted in 48 % of cases in group 1 and in 10 % of cases in group 2. An assessment of patient satisfaction with the use of the application (B 2C (business-to-consumer) analysis) revealed satisfaction in 91.4 % of respondents.Conclusion. The availability and effectiveness of the use of the PSP «Healthy Skin» will ensure timely supportive care, significantly reduce the severity of skin toxicity and improve the quality of life in oncology patients.
Association of body composition of patients with chronic heart failure with the course of the disease
Authors: Shevtsova V. I. , Pashkova A. A. , Salamatova V. N. , Shevtsov A. N. , Krasnoruckaya O. N. 
Published: December 2024

Aim. To identify the relationship between the nutritional status of patients suffering from chronic heart failure (CHF) and their clinical condition.Materials and methods. The study involved 298 people: 115 men and 183 women (the average age was 61 years). After body composition assessment, the patients were divided into 5 groups: group 1 – reduced weight + sarcopenia (n=45); group 2 – normal weight + sarcopenia (n=79); group 3 – normal weight without sarcopenia (n=49); 4th group – obesity + sarcopenia (n=72); group 5 – obesity without sarcopenia (n=53). The clinical condition of patients in the study groups was assessed with the determination of functional class (FC), ejection fraction (EF), and the analysis of laboratory parameters such as C-reactive protein (CRP), N-terminal natriuretic propeptide B-type (NT-proBNP) and galectin‑3 was carried out.Results. The most unfavorable course of CHF was determined in patients with reduced body weight and sarcopenia. Thus, in group 1, FC IV was more common than in others (42.2%), FC II was not determined at all. The EF values were the lowest and amounted to 27–36%. The least severe course of CHF was observed in patients with normal body weight without sarcopenia. FC II was more common in group 3 (67.3%). At the same time, the EF was reduced or intermediate. In the obese groups, the course of the disease was less favorable than in the group with normal body composition. However, it is better than in patients with sarcopenia alone. In groups 4 (47.2%) and 5 (52.8%), FC III was more common, and the values of the EF exceeded 50%.Conclusion. Changes in the body composition of patients suffering from CHF are definitely associated with the severity of the disease and relate to unfavorable prognostic factors. To choose the most effective treatment tactics for patients, it is necessary to identify the clinical phenotypes of CHF with an assessment of the components of body composition.
DEVELOPMENT OF ANAEMIA TREATMENT USING ETHANOL EXTRACT OF MIRABILIS JALAPA YELLOW FLOWERS
Authors: Widyanti Fera , Indarto Dono , Suselo Yuliana Heri 
Published: December 2024

Mirabilis jalapa merupakan tumbuhan tropis dengan berbagai warna yang banyak ditemukan di Indonesia namun saat ini pemanfaatannya hanya sebatas tanaman hias dan pagar. Kombinasi M. jalapa warna kuning dan pink memiliki fitokimia yang berperan dalam metabolisme zat besi tetapi belum ada penelitian terkait dengan kandungan zat gizi. Penelitian ini bertujuan untuk mengidentifikasi kandungan zat gizi dan fitokimia ekstrak M. jalapa warna kuning dengan jenis penelitian deskriptif eksploratif. M. jalapa warna kuning terlebih dahulu digiling menjadi serbuk kemudian dilakukan maserasi dengan menggunakan larutan heksana dan etanol selama 24 jam di Laboratorium Fitokimia Fakultas Farmasi Universitas Setia Budi Surakarta pada bulan Januari 2024. Besi dan seng dianalisis dengan metode Atomic Absorption Spectrum (AAS) di Fakultas MIPA Universitas Gadjah Mada Yogyakarta. Kandungan zat gizi dianalisis dengan menggunakan uji proximate dan kandungan fitokimia dengan Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) pada mode ionisasi positif dan negatif di LPPT Universitas Gadjah Mada Yogyakarta. Penelitian dilaksanakan pada bulan Februari-April 2024. Ekstrak etanol M. jalapa kuning mengandung kadar air 18.71%, abu 12.08%, protein 25%, lemak 4.74%, karbohidrat 39.47%, besi 0.11%, seng 8.95% dan vitamin C 5.51%. Fitokimia family Betaxanthin terdeteksi pada mode ionisasi positif sedangkan Betacyanin ditemukan pada mode ionisasi negatif. Ekstrak etanol M. jalapa kuning mengandung besi dan Betaxanthin yang berpotensi untuk terapi alternatif anemia.
Emergências psiquiátricas durante a gestação: uma revisão de literatura
Authors: Azevedo Erickson Fernando Carvalho de , Névoa Ana Carolina de Lima Lopes , Fazan Valéria Paula Sassoli , Inocente Otavio Samuel Tassi , Neto Albino Inocente , Peruzzo Renata Pereira Peres , Rocha Luís Eduardo de Araújo , Ribeiro Eduardo Andrade , Filho Carlos Alberto de Oliveira , Carvalho Millena Almeida de , Ceigol Pedro Augusto Balarim , Costa Maria Laura Marques , Almeida Ana Laura Carvalho 
Published: December 2024

A gestação é um período marcado por profundas mudanças biológicas, psicológicas e sociais, que podem exacerbar ou desencadear transtornos psiquiátricos em mulheres predispostas. As emergências psiquiátricas, como transtornos de humor, ansiedade, psicose e uso de substâncias, requerem intervenções rápidas devido ao seu impacto na saúde materna e nos desfechos obstétricos. O objetivo dessa pesquisa consistiu em explorar as principais condições psiquiátricas emergenciais, suas implicações para a saúde materno-fetal e as abordagens terapêuticas mais adequadas para cada casos e para sua confecção, foram realizadas buscas em bases de dados renomadas, selecionando-se 16 artigos referenciais que se enquadraram nos critérios pré-estabelecidos. O manejo dessas condições psiquiátricas exige uma abordagem multidisciplinar e individualizada, considerando os efeitos dos tratamentos no feto e equilibrando os riscos teratogênicos com os benefícios para a saúde mental da gestante. Assim, a gestão das emergências psiquiátricas na gestação é um campo complexo que demanda coordenação entre profissionais de saúde.
Ajuga iva extract lowers plasma cholesterol and improves lipoprotein profile and lecithin: cholesterol acyltransferase (LCAT) activity in rats fed high cholesterol diet
Authors: Abdelkader Chenni , Zohra Madani , Zohra Hamza-Cherif Fatima , Laura Pucci , Dalila Ait Yahia 
Published: December 2024

The purpose of the study was to investigate the therapeutic and preventive effects of Ajuga iva (L) Schreber (Labiatae) (Ai) extract on hypercholesterolemic model rats. For this aim, male Wistar rats were fed a high‑cholesterol (1%) diet to establish a hypercholesterolemia model supplemented or not with aqueous extract of Ajuga Iva (Ai) (5 g/kg diet) for 4 weeks. Ai lowered plasma total cholesterol (TC) (18%) with a reduction in cholesteryl esters (CE) (29%). Low VLDL-TC and high HDL2-TC were observed in Ai group. TC/HDL’s -C ratio was 1.64-fold lower, whereas HDL’s-C/ LDL-HDL1-C was 1.82-fold higher in Ai treated rats. Triacylglycerols (TG) were reduced in plasma and in VLDL but increased in HDL2 and HDL3 with Ai supplementation. Rats exposed to Ai diet lowered VLDL-unesterified cholesterol (UC), LDL-HDL1-amount and LDL-HDL1-CE but increased HDL3-CE. Low levels of liver phospholipids (PL) and high CE concentrations were observed in Ai group. In aorta, TC was decreased by 37% with Ai. Feeding Ai diet decreased HDL3-PL and increased HDL2-CE and plasma LCAT activity. Moreover, Ai administration (5 g/kg for 4 weeks) improved liver and kidney function, as demonstrated by decreased plasma aspartate aminotransferase (AST) activity and creatinine, and resulted in an increase of urinary and sodium excretion. We conclude that, in addition to its Strong C and TG-lowering effect, Ai improves effectively the atherogenic lipoproteins profile by reducing the LDL-HDL1 amount and increasing the HDL-cholesterol. Furthermore, Ai increases the reverse cholesterol transport by enhancement of cholesterol: acyltransferase (LCAT) activity. These beneficial effects are considered potential mechanisms through which Ai acts as a protective agent against cholesterol-induced damage, ensuring cardiovascular safety.
Vesiculite seminal aguda complicada com abscesso: aspectos radiológicos de entidade urológica incomum
Authors: Camilo Rafael Pimenta , Vitorino Victória Beatriz da Silva , Byrro Mariana Ribeiro Cunha 
Published: December 2024

A vesiculite seminal aguda é uma rara entidade inflamatória que acomete as vesículas seminais, comumente de causa infecciosa, secundária a prostatite por uretrite gonocócica. Pode ser complicada com abscesso, geralmente em pacientes imunossuprimidos, e deve ter diagnóstico preciso e eficaz para se evitar desdobramentos ainda mais graves. A sintomatologia é vasta, sem contar com sinais ou sintomas característicos e, por isso, pode ter suspeição clínica retardada. Devido à localização de difícil acesso, os estudos radiológicos têm grande importância no diagnóstico de tais afecções. A primeira linha de tratamento é a antibioticoterapia, aliada ou não a drenagem transperineal, transuretral ou percutânea, se não houver resposta à terapia medicamentosa.
Influência do exercício físico no tratamento de transtornos mentais: uma revisão sistemática
Authors: Flora Isis Della , Silva Beatriz Evilym Dutra da , Neto Francisco Porfírio da Silva , Moreira Davi Coelho , Soares Bruna Rodrigues , Sant’Ana Paula Grippa 
Published: December 2024

Introdução: Com o aumento progressivo e global no número de casos de transtornos mentais, novas técnicas têm sido estudadas para frear esse problema. Dentre os principais transtornos, destacam-se os Transtornos de ansiedade, relacionados com receptores GABA, 5-TH e a hipersensibilidade a colecistocinina (CCK), e os transtornos de humor, principalmente a depressão e bipolaridade com principal causa estando relacionada ao sistema monoaminérgico, que nesses transtornos apresentam transmissões sinápticas disfuncionais. Dessa forma, a adesão do exercício físico na rotina de pacientes com tais transtornos, é um importante tratamento coadjuvante aos fármacos. Objetivo: abordar a influência dos exercícios físicos na redução dos sintomas de transtornos de ansiedade e de humor. Metodologia: revisão sistemática de artigos de revisão e ensaios clínicos randomizados, em inglês e português, publicados nas bases de dados Medline, Pubmed, Google Acadêmico e Scielo entre 2017 e 2024, utilizando os descritores Anxiety, Depression, Exercise. Resultados: Foram encontrados 24 artigos e incluídos 12, desses, 3 detalham sobre os efeitos do exercício aeróbico isolado, outros 2 sobre os efeitos do exercício físico resistido isolado, enquanto os outros 7 tratam da influência dos dois tipos de exercício, de forma isolada ou associados no tratamento dos desarranjos mentais. Conclusão: Esta revisão confirma os benefícios oriundos da prática do exercício físico no tratamento e redução das consequências dos transtornos de
Phytochemical screening, antioxidant and anti-inflammatory activities of Rosmarinus officinalis medicinal plant from Algeria
Authors: Benattouche Zouaoui , Bouhadi Djilali , Alioui Abdelatif 
Published: December 2024

This study aims to investigate phytochemical screening, total polyphenol, flavonoids and tannins content, antioxidant activities, and anti-infalammatory effects of methanol, water and ethyl acetate extracts of R.officinalis L growing in Mascara region (Algeria). The extracts were screened for their possible antioxidant activity was determined by DPPH free radical-scavenging and reducing power assay, in vitro anti-inflammatory activity was evaluated by membrane stabilization method using sodium diclofenac as a reference drug. Phytochemical screening of the extracts revealed a presence of tannins (total and gallic), flavonoids, phenols, quinones, coumarins, saponosides, teranoids. and Reducing sugar.. The results showed that methanolic extract significantly (P˂ 0.05) antioxidant than the aqueous and ethyl acetate extract with IC50 values of (5.032 ± 1.003 μg/ml). Furthemore, the ethyl acetate extract showed significantly (P˂ 0.05) inhibition of hypotonicity induced haemolysis 94.36 % at concentration of 250 μg/ml compared to 50 % for sodium diclofenac at 100 μg/ml. The results obtained confirm the traditional therapeutic effects and these plants can be a potential source of anti-inflammatory drug.
POLEMIK WACANA KANTOR URUSAN AGAMA (KUA) MENJADI TEMPAT PERNIKAHAN DAN PENCATATAN SEMUA AGAMA
Authors: SULAIMAN IKBAL 
Published: December 2024

The idea of making the Office of Religious Affairs (Kantor Urusan Agama, KUA) a marriage registry for all religions in Indonesia has sparked significant debate. The Office of Religious Affairs (KUA) is a government institution responsible for the development and guidance of religious life in the community. The role of the KUA as a marriage registry for all religions has been the subject of intense debate in recent years. The Ministry of Religious Affairs' initiative to make the Office of Religious Affairs an inclusive center for religious services has attracted much controversy. This study aims to analyze the social and cultural impact of the implementation of the discourse, taking into account the potential for increased interfaith tolerance as well as the risk of conflict that may arise and analyzing the social and cultural impact of the implementation of the KUA as a place of marriage registration for all religions. The results show that this discourse raises pros and cons from various figures. If the KUA successfully transforms into an institution that serves all religions, it may trigger a cultural paradigm shift in society. People may become more open to other religious practices and reduce the negative stigma against religious minorities. This could be the first step towards a more inclusive society. On the other hand, there is a risk that integrating these services could lead to a blurring of each religion's identity. Some groups may feel that their religious traditions and practices are no longer valued or fully recognized in the context of these shared services. This research uses a type of normative legal research, which conducts research on library legal materials or secondary data. Normative legal research examines positive legal norms in the form of laws and regulations, this research explores the views of the community and religious leaders regarding the change in the function of the KUA, as well as the steps needed to implement this policy effectively
A DEIXIS ANALYSIS OF OLIVIA RODRIGO'S SONGS "DEJA VU" AND "SO AMERICAN”
Authors: UMAR SHARLA SHAKILA , STEPHANI CHELCEA ANGELICA , ROSALINAH YANTI 
Published: December 2024

This study analyzes the use of deixis in Olivia Rodrigo's songs "Deja Vu" and "So American." Deixis provides contextual clues in language, helping identify the speaker, listener, time, and place. The study aims (1) to identify the types of deixis and (2) to analyze singer’s feelings referring to her experiences in relationships in the song lyrics from Deja Vu dan So American. Using Yule’s theory of deixis, along with insights from Ferdinand de Saussure and Noam Chomsky. The research focuses on personal, spatial, and temporal deixis. This analysis reveals how Rodrigo's lyrics effectively use linguistic strategies to enhance emotional expression and connection with listeners.
PENGARUH KUALITAS SUMBER DAYA MANUSIA, PROFESIONALISME KERJA DAN WORK LIFE BALANCE TERHADAP KINERJA KARYAWAN PERUMDA AIR MINUM TIRTA HITA BULELENG
Authors: GAUTAMA ANAK AGUNG NGURAH RESTU , WIGUNA I GUSTI NGURAH KADEK ANGGA 
Published: December 2024

Human resources are still a concern for organizational companies to survive. Having quality resources when we are able to be given responsibility and exercise authority, however,a number of problems were found related to the quality of HumanResources Quality,Professionalismof Work, Work Life Balance, Employee’s.Performance atPerumda Air MinumTirta Hita Buleleng, sothe examiner was interested inexamining the effect of Human ResourcesQuality, Professionalism ofWork and Work Life Balance,onemployee’s performance at PerumdaAir Minum Tirta Hita Buleleng. This test has an achievement to find outhow the influence of Human Resources Quality, Professionalism of Work, along with worklifebalance on the performanceof Perumda Air Minum TirtaHita Bulelengemployees. Thedata collection technique usedin this test is aquestionnaire to analyze the data quantitatively using,coefficient ofdetermination, multiple linear regressionanalysis, f-test analysis, t hypothesis test.The sample in this test is the central employees of Perumda Air Minum Tirta Hita Buleleng with a total of 136 respondents. Thedata analysis used inthis study is multiplelinear regressionanalysis, classical assumptiontest, f-test analysis and hypothesis t analysis. Based onthe results in this test, it can beconcluded thatthe quality of humanresources, workprofessionalism, andwork lifebalance have a significantpositive effect onemployee’sperformance.