bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost Utility Analysis of Dupilumab Versus Endoscopic Sinus Surgery for Chronic Rhinosinusitis With Nasal Polyps
Authors: Scangas George A. , Wu Arthur W. , Ting Jonathan Y. , Metson Ralph , Walgama Evan , Shrime Mark G. , Higgins Thomas S. 
Published: April 2020

ObjectiveBoth endoscopic sinus surgery (ESS) and biologic therapies have shown effectiveness for medically‐refractory chronic rhinosinusitis with nasal polyps (CRSwNP) without severe asthma. The objective was to evaluate cost‐effectiveness of dupilumab versus ESS for patients with CRSwNP.Study DesignCohort‐style Markov decision‐tree economic model with a 36‐year time horizon.MethodsA cohort of 197 CRSwNP patients who underwent ESS were compared with a matched cohort of 293 CRSwNP patients from the SINUS‐24 and SINUS‐52 Phase 3 studies who underwent treatment with dupilumab 300 mg every 2 weeks. Utility scores were calculated from the SNOT‐22 instrument in both cohorts. Decision‐tree analysis and a 10‐state Markov model utilized published event probabilities and primary data to calculate long‐term costs and utility. The primary outcome measure was incremental cost per quality‐adjusted life year (QALY), which is expressed as an Incremental Cost Effectiveness Ratio. One‐way and probabilistic sensitivity analyses were performed.ResultsThe ESS strategy cost $50,436.99 and produced 9.80 QALYs. The dupilumab treatment strategy cost $536,420.22 and produced 8.95 QALYs. Because dupilumab treatment was more costly and less effective than the ESS strategy, it is dominated by ESS in the base case. One‐way sensitivity analyses showed ESS to be cost‐effective versus dupilumab regardless of the frequency of revision surgery and at any yearly cost of dupilumab above $855.ConclusionsThe ESS treatment strategy is more cost effective than dupilumab for upfront treatment of CRSwNP. More studies are needed to isolate potential phenotypes or endotypes that will benefit most from dupilumab in a cost‐effective manner.Level of Evidence2C Laryngoscope, 131:E26–E33, 2021
Zonal Reconstruction of Photonic Wavefunction via Momentum Weak Measurement
Authors: Yang Mu , Xiao Ya , Liao Yu‐Wei , Liu Zheng‐Hao , Xu Xiao‐Ye , Xu Jin‐Shi , Li Chuan‐Feng , Guo Guang‐Can 
Published: April 2020

AbstractDirect measurement of wavefunctions has attracted great interest and many different methods have been developed. However, the precision of current techniques is limited by the use of Fourier transform lenses. These measurements require to shear cut the part of particles with momentum , which greatly restricts the efficiency and application of the approaches. Here, a method to directly measure 2D photonic wavefunctions is proposed and experimentally demonstrated by combining the momentum weak measurement technology and the zonal wavefront restoration algorithm. Both the Gaussian and Laguerre–Gaussian wavefunctions are experimentally well reconstructed. This method avoids using the Fourier lens and post selection on the momentum . This is further applied to measure wavefronts with ultra‐high spatial frequency and achieve a pixel resolution, which is difficult for traditional Shack–Hartmann wavefront sensing technologies. This work extends the ability of quantum measurement techniques and will be useful for high‐resolution wavefront sensing.
Lactobacillus Casei Zhang Alleviates Shrimp Tropomyosin‐Induced Food Allergy by Switching Antibody Isotypes through the NF‐κB‐Dependent Immune Tolerance
Authors: Fu Linglin , Xie Menghua , Wang Chong , Qian Yi , Huang Jianjian , Sun Zhihong , Zhang Heping , Wang Yanbo 
Published: April 2020

ScopeShellfish allergy is an important cause of food allergy, and tropomyosin (TM) is the major allergen within shellfish. Probiotics are safe bacteria that benefit host health and nutrition and is proposed as a novel approach for treating immunological diseases, including food allergies.Methods and resultsThe probiotic strain Lactobacillus casei Zhang (LcZ) isolated from koumiss is investigated for its capacity to modulate food allergy induced by TM in BALB/c mice. Oral administration of LcZ attenuated allergy symptoms and intestinal epithelial damage. Furthermore, flow cytometry, real‐time quantitative PCR, and ELISA demonstrated that LcZ administration altered the development and function of dendritic cells (DCs), T cells, and B cells, finally resulting in the change of TM‐specific antibody isotypes into a tolerogenic pattern. Moreover, an in vitro spleen cell culture model reveals that LcZ directly modulates regulatory tolerogenic DC and T cell development, dependent on the activation of the nuclear factor kappa B (NF‐κB) signaling pathway.ConclusionThis work indicates the ability of LcZ to alleviate TM‐induced food allergy and demonstrates the involvement of the tolerogenic immune cells and NF‐κB signaling pathway, indicating LcZ to be a potential immunomodulator and immunotherapy assistor.
Microwave pressure sensor based on transmission response of a quarter‐wavelength single stub microstrip line
Authors: Shamabadi Ali Asghar , Rezaee Morteza , Kazemi‐Beydokhti Amin 
Published: April 2020

AbstractA microwave pressure sensor based on variations in the transmission zero of a microstrip circuit is proposed in this article. The structure of the sensor is consisting of a microstrip line connected in parallel to a single stub, which the stub is terminated in a reactive load. When the length of stub is around quarter‐wavelength, the frequency of the transmission zero of microstrip line can be controlled by the reactance value. Therefore, by using a simple parallel plate capacitor as a transducer in which its capacitance is changed by the pressure, a microwave pressure sensor is realized. A prototype pressure sensor by using a circular‐shape parallel plate capacitor is designed and fabricated that the measurement results show a good linear variation of transmission zero with pressure with sensitivity of −0.57 MHz/kPa when the pressure changes from 0 to 466 kPa.
Differentiated adipose‐derived stem cells promote peripheral nerve regeneration
Authors: Yamamoto Daiki , Tada Kaoru , Suganuma Seigo , Hayashi Katsuhiro , Nakajima Tadahiro , Nakada Mika , Matsuta Masashi , Tsuchiya Hiroyuki 
Published: April 2020

AbstractIntroductionMany reports have indicated that adipose‐derived stem cells (ADSCs) are effective for nerve regeneration. We investigated nerve regeneration by combining a polyglycolic acid collagen (PGA‐c) tube, which is approved for clinical use, and Schwann cell‐like differentiated ADSCs (dADSCs).MethodsFifteen‐millimeter‐long gaps in the sciatic nerve of rats were bridged in each group using tubes (group I), with tubes injected with dADSCs (group II), or by resected nerve (group III).ResultsAxonal outgrowth was greater in group II than in group I. Tibialis anterior muscle weight revealed recovery only in group III. Latency in nerve conduction studies was equivalent in group II and III, but action potential was lower in group II. Transplanted dADSCs maintained Schwann cell marker expression. ATF3 expression level in the dorsal root ganglia was equivalent in groups II and III.DiscussiondADSCs maintained their differentiated state in the tubes and are believed to have contributed to nerve regeneration.
Ocular cytomegalovirus latency exacerbates the development of choroidal neovascularization
Authors: Xu Jinxian , Liu Xinglou , Zhang Xinyan , Marshall Brendan , Dong Zheng , Liu Yutao , Espinosa‐Heidmann Diego G , Zhang Ming 
Published: April 2020

AbstractAge‐related macular degeneration (AMD) is a complex, multifactorial, progressive disease which represents a leading cause of irreversible visual impairment and blindness in older individuals. Human cytomegalovirus (HCMV), which infects 50–80% of humans, is usually acquired during early life and persists in a latent state for the life of the individual. In view of its previously described pro‐angiogenic properties, we hypothesized that cytomegalovirus might be a novel risk factor for progression to an advanced form, neovascular AMD, which is characterized by choroidal neovascularization (CNV). The purpose of this study was to investigate if latent ocular murine cytomegalovirus (MCMV) infection exacerbated the development of CNV in vascular endothelial growth factor (VEGF)‐overexpressing VEGF‐Ahyper mice. Here we show that neonatal infection with MCMV resulted in dissemination of virus to various organs throughout the body including the eye, where it localized principally to the choroid in both VEGF‐overexpressingVEGF‐Ahyper and wild‐type(WT) 129 mice. By 6 months post‐infection, no replicating virus was detected in eyes and extraocular tissues, although virus DNA was still present in all eyes and extraocular tissues of both VEGF‐Ahyper and WT mice. Expression of MCMV immediate early (IE) 1 mRNA was detected only in latently infected eyes of VEGF‐Ahyper mice, but not in eyes of WT mice. Significantly increased CNV was observed in eyes of MCMV‐infected VEGF‐Ahyper mice compared to eyes of uninfected VEGF‐Ahyper mice, while no CNV lesions were observed in eyes of either infected or uninfected WT mice. Protein levels of several inflammatory/angiogenic factors, particularly VEGF and IL‐6, were significantly higher in eyes of MCMV‐infected VEGF‐Ahyper mice, compared to uninfected controls. Initial studies of ocular tissue from human cadavers revealed that HCMV DNA was present in four choroid/retinal pigment epithelium samples from 24 cadavers. Taken together, our data suggest that ocular HCMV latency could be a significant risk factor for the development of AMD. © 2020 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The effect of glycidyl methacrylate and styrene comonomers on compatibility, physical‐mechanical properties, and swelling behavior of SBR/NBR blends
Authors: Javadzadeh Mohammad , Arefazar Ahmad , Zakizadeh Mehrad 
Published: April 2020

AbstractThe effect of functionalized styrene‐butadiene rubber (SBR) with glycidyl methacrylate (GMA) monomers, in the presence of styrene comonomers (SBR‐g‐GMA‐co‐St) as a compatibilizer on physical‐mechanical, morphological, and swelling behavior of SBR/nitrile butadiene rubber (NBR) blends were studied. It was proved that the compatibilizer made through dicumyl peroxide‐induced reaction which possessed 1.5 phr GMA in addition to 1.5 phr styrene comonomers showed higher efficiency of grafting. Possible in situ reactions between SBR‐g‐GMA‐co‐St and NBR component also were evaluated with an attenuated total reflectance mode of Fourier‐transform infrared spectroscopy. SBR/NBR blend containing compatibilizer with a middle value of grafting demonstrated the most reactions between components. Dynamic mechanical thermal analysis results illustrated that the presence of SBR‐g‐GMA‐co‐St caused a significant improvement in compatibility of two components. This was verified with the scanning electron microscope pictures in which a smoother surface of the sample was clear. The enhancement in microstructure led to an increase in tensile strength, elongation at break, and storage modulus. Moreover, the increase in the intermolecular cross‐links and made interactions considerably affected blends' swelling behavior in both hydrocarbon solvents (carbon tetrachloride and chloroform).
Effects of phosphateemulsion‐basedmontmorillonite on structure and properties ofpoly(styrene‐ethylene‐butylene‐styrene)triblock copolymer
Authors: Yu Hui , Li Jun , Chen Gang , Zhang Ruifeng , Li Yangyang , Qiu Biwei , Li Xiaoyan 
Published: April 2020

AbstractA long alkyl chain quaternary phosphonium cationic surfactant is used to form stable bisphenol A diphenyl diphosphate (BDP) emulsion in water/acetone mixed solutions. BDP emulsion‐based montmorillonite (BMMT) is prepared by cation exchange between quaternary phosphonium on the surface of the emulsion and montmorillonite. Nanocomposites of BMMT and poly(styrene‐ethylene‐butylene‐styrene) (SEBS) thermoplastic elastomers are prepared by solvent blending. Morphology, dynamic mechanical properties and dynamic rheological analysis show that high content of BMMT can be uniformly dispersed in SEBS, while plasticized BDP reduces the entanglement of SEBS molecular chains and increases the friction loss between molecular chains and nanoclay. BMMT does not change the glass transition temperature of the SEBS soft segment, and the labyrinth effect of nanoclay can reduce the migration of BDP to the polymer surface. Flame‐retardant tests show that BDP and nanoclay flakes form dense carbon during the combustion process, and the nanocomposite shows good flame retardancy and hydrolysis resistance.
Synthesis of cyclic aromatic polymer containing thiophene or pyridine by means of unstoichiometric Suzuki‐Miyaura cyclic polycondensation: Effect of the position of bromine of heteroarylenes on cyclic polycondensation
Authors: Sugita Hajime , Ohta Yoshihiro , Yokozawa Tsutomu 
Published: April 2020

AbstractSuzuki‐Miyaura cyclic polycondensation of 1.3 equivalents of thiophene dibromide or pyridine dibromide with 1.0 equivalent of phenylenediboronic acid ester was investigated in the presence of t‐Bu3PPd G2 precatalyst, which generates t‐Bu3PPd(0), and CsF/18‐crown‐6 as a base. Polycondensation of 2,5‐dibromothiophene and 5,5′‐dibromo‐2,2′‐bithiophene with pinacol meta‐phenylenediboronate (2) yielded corresponding cyclic polymers. On the other hand, polycondensation of 3,4‐dibromothiophene with para‐phenylenediboronate (5) gave linear polymer with bromothiophene at both ends via conventional unstoichiometric polycondensation involving excess dibromo monomer, implying that intramolecular catalyst transfer did not proceed effectively on 3,4‐dibromothiophene. A model reaction of 3,4‐dibromothiophene with phenylboronic acid indeed gave monosubstituted thiophene preferentially via intermolecular catalyst transfer. In the polycondensation of excess pyridine dibromide with 5, the use of 2,6‐dibromopyridine gave linear polymer, whereas the use of 3,5‐dibromopyridine yielded cyclic polymer. Thus, the position of bromine in heteroarylenes determines whether cyclic polymer or linear polymer is formed, in contrast to the case of unstoichiometric Suzuki‐Miyaura cyclic polycondensation with dibromophenylenes.
Right atrial cardiac myxoma and multiple pulmonary artery aneurysms: Is there a causal relationship?
Authors: Batra Rohit , Malec Edward , Heitkoetter Birthe , Stegger Julia , Kleinerueschkamp Felix , Januszewska Katarzyna 
Published: April 2020

AbstractCardiac myxomas are rare occurrences in pediatric populations, as are pulmonary artery aneurysms. We report a 17‐year‐old adolescent with right atrial cardiac myxoma and concomitant multiple peripheral pulmonary artery aneurysms. Histological examination indicated infiltration of the pulmonary artery wall through the embolic cardiac myxoma cells, thereby weakening it. This report highlights the probable causal relationship between these two entities, proposes the possible pathomechanism and presents the diagnostic and therapeutic dilemmas in the management of this condition.
A study of Solvent and Antisolvent Influence on the Crystal Morphology of ϵ‐CL‐20 by a Modified Attachment Energy Model
Authors: Zhao Li , Li Jing , He Jinxuan , Luo Peicheng , Shi Liangwei , Zhou Junhong , Pang Aimin 
Published: April 2020

AbstractIn this work the dominant crystal faces of ϵ‐CL‐20 in vacuum was firstly obtained as (011), (10‐1), (110), (11‐1), (002), (101), (021) by the attachment energy (AE) model. Then the modified AE (MAE) model was used to predict the crystal morphologies of ϵ‐CL‐20 in five pure solvents including ethyl acetate (EA), acetone, acetonitrile, cyclohexane and methanol, and five solvent mixtures of EA/chloroform, EA/dichloromethane, EA/n‐heptane, EA/cyclohexane and EA/1‐propyl alcohol. Results demonstrate that different types of solvent and antisolvent can produce different dominant faces and the corresponding face area, consequently, affecting the crystal morphology. The effect of the volume ratio of the antisolvent to the solvent on the crystal morphologies was further investigated. Finally, the radial distribution function (RDF) of the interfacial model was used to analyze the adsorption behaviors of the solvent molecules on the CL‐20 surfaces.
Management of yellow dwarf disease in Europe in a post‐neonicotinoid agriculture
Authors: Mc Namara Louise , Gauthier Kevin , Walsh Lael , Thébaud Gaël , Gaffney Michael , Jacquot Emmanuel 
Published: April 2020

AbstractBarley/cereal yellow dwarf viruses (YDVs) cause yellow dwarf disease (YDD), which is a continuous risk to cereals production worldwide. These viruses cause leaf yellowing and stunting, resulting in yield reductions of up to 80%. YDVs have been a consistent but low‐level problem in European cereal cultivation for the last three decades, mostly due to the availability of several effective insecticides (largely pyrethroids and more recently neonicotinoids) against aphid vectors. However, this has changed recently, with many insecticides being lost, culminating in a recent European Union (EU) regulation prohibiting outdoor use of the neonicotinoid‐insecticide compounds. This change is coupled with the growing challenge of insecticide‐resistant aphids, the lack of genetic resources against YDVs, and a knowledge deficit around the parameters responsible for the emergence and spread of YDD. This means that economic sustainability of cereal cultivation in several European countries including France and United Kingdom is now again threatened by this aphid‐vectored viral disease. In this review, we summarize the current knowledge on the YDV pathosystem, describe management options against YDD, analyse the impacts of the neonicotinoid ban in Europe, and consider future strategies to control YDV. © 2020 Society of Chemical Industry
Extremely Foldable and Highly Porous Reduced Graphene Oxide Films for Shape‐Adaptive Triboelectric Nanogenerators
Authors: Hwang Hee Jae , Yeon Jeong Seok , Jung Yeonseok , Park Ho Seok , Choi Dukhyun 
Published: April 2020

AbstractHere, a thin and foldable porous reduced graphene oxide (rGO) fabricated by a solvent casting method (SC‐rGO) is introduced. The SC‐rGO is superior to aluminum as a positive triboelectric material in triboelectric nanogenerators (TENGs), significantly enhancing TENG output performance. The film shows extremely foldable features, where it could be folded by 1/16 size. The electrical properties and device performance of SC‐rGO are optimized varying thicknesses from 5 to 30 µm. A 30 µm thick TENG with a non‐annealed SC‐rGO film (STENG) shows the highest output of about 255 µW cm−2 due to its high carrier concentration, low work function, and high surface area. After annealing, STENG performance is optimized with a 10 µm thick SC‐rGO because their work functions decreases, while the corresponding carrier concentrations decrease according to the thickness of the SC‐rGO films. The SC‐rGO films are highly durable and stable, where their output and conductivity show negligible changes after 100 000 cycles of mechanical deformation. A large SC‐rGO with a size of 13 × 3 cm2 is fabricated and is attached inside a person's arm to demonstrate the shape‐adaptive characteristics. Consequently, 170 V is obtained and it turns on 19 green light emitting diodes by simply touching the STENG.
Testing generic limits in Cercidoideae (Leguminosae): Insights from plastid and duplicated nuclear gene sequences
Authors: Sinou Carole , Cardinal‐McTeague Warren , Bruneau Anne 
Published: April 2020

AbstractReconstructing the phylogenetic history of species in large taxonomic groups remains a challenge despite ever increasing access to molecular data. In subfamily Cercidoideae (Leguminosae), the large pantropicalBauhinias.l. (~380 spp.) is never supported as monophyletic, but the generic boundaries and the number of genera that should be recognised remains a challenging taxonomic and phylogenetic question. Here we reconstruct the phylogeny ofBauhinias.l. and related genera in the subfamily using sequences obtained from five loci (matK,trnL‐F,Leafy, and two previously undetected duplicate copies ofLegcyc), which we analyse individually and in a concatenated matrix (excludingLeafy). The individual and concatenated analyses generally support two distinct lineages inBauhinias.l.: (1) the Bauhinia clade, containingBauhinias.str.,Brenierea, andPiliostigma; and (2) the Phanera clade, containingBarklya,Cheniella,Gigasiphon,Lasiobema,Lysiphyllum,Phaneras.str.,Schnella, andTylosema. Based on our analyses, we recognise 14 genera in Cercidoideae. We resurrect the genusTournayafromGigasiphon, and synonymise the Asian segregate genusLasiobemaback intoPhaneras.str. Our analyses reveal a clear gene duplication event inCYCLOIDEAthat is shared by all Cercidoideae excluding the sister lineage to the subfamily,Cercis, supporting recent hypotheses for a whole genome duplication in all Cercidoideae except this genus.
Spectral theory of a class of nilmanifolds attached to Clifford modules
Authors: Bauer Wolfram , Furutani Kenro , Iwasaki Chisato , Laaroussi Abdellah 
Published: April 2020

AbstractWe determine the spectrum of the sub-Laplacian on pseudo H-type nilmanifolds and present pairs of isospectral but non-homeomorphic nilmanifolds with respect to the sub-Laplacian. We observe that these pairs are also isospectral with respect to the Laplacian. More generally, our method allows us to construct an arbitrary number of isospectral but mutually non-homeomorphic nilmanifolds. Finally, we present two nilmanifolds of different dimensions such that the short time heat trace expansions of the corresponding sub-Laplace operators coincide up to a term which vanishes to infinite order as time tends to zero.
Nonlinear Stability of the Milne Model with Matter
Authors: Andersson Lars , Fajman David 
Published: April 2020

AbstractWe show that any$$3+1$$3+1-dimensional Milne model is future nonlinearly, asymptotically stable in the set of solutions to the Einstein–Vlasov system. For the analysis of the Einstein equations we use the constant-mean-curvature-spatial-harmonic gauge. For the distribution function the proof makes use of geometric$$L^2$$L2-estimates based on the Sasaki-metric. The resulting estimates on the energy-momentum tensor are then upgraded by employing the natural continuity equation for the energy density. The combination of$$L^2$$L2-estimates and the continuity equation reveals a powerful tool to analyze massive transport equations with potential applications beyond the result presented here.
Complete Genome Sequence of Pantoea ananatis Strain NN08200, an Endophytic Bacterium Isolated from Sugarcane
Authors: Zeng Quan , Shi GuoYing , Nong ZeMei , Ye XueLian , Hu ChunJin 
Published: April 2020

AbstractStain NN08200 was isolated from the surface-sterilized stem of sugarcane grown in Guangxi province of China. The stain was Gram-negative, facultative anaerobic, non-spore-forming bacteria. The complete genome SNP-based phylogenetic analysis indicate that NN08200 is a member of the genus Pantoea ananatis. Here, we summarize the features of strain NN08200 and describe its complete genome. The genome contains a chromosome and two plasmids, in total 5,176,640 nucleotides with 54.76% GC content. The chromosome genome contains 4598 protein-coding genes, and 135 ncRNA genes, including 22 rRNA genes, 78 tRNA genes and 35 sRNA genes, the plasmid 1 contains 149 protein-coding genes and the plasmid 2 contains 308 protein-coding genes. We identified 130 tandem repeats, 101 transposon genes, and 16 predicted genomic islands on the chromosome. We found an indole pyruvate decarboxylase encoding gene which involved in the biosynthesis of the plant hormone indole-3-acetic acid, it may explain the reason why NN08200 stain have growth-promoting effects on sugarcane. Considering the pathogenic potential and its versatility of the species of the genus Pantoea, the genome information of the strain NN08200 give us a chance to determine the genetic background of interactions between endophytic enterobacteria and plants.