bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery of Amorphous Iron Hydrides via Novel Quiescent Reaction in Aqueous Solution
Authors: Taguchi Kohei , Shinozaki Kazuteru , Okumura Hideyuki , Michioka Chishiro , Yoshimura Kazuyoshi , Ishihara Keiichi N. 
Published: April 2020

AbstractNovel amorphous iron hydrides (AIHs) are synthesized for the first time under ambient conditions by employing novel “quiescent reaction”, without stirring for mixing solutions, during a conventional aqueous reduction-precipitation process. The kind and morphology of AIHs are dependent on the processing condition, where two types are found, with one form consisting of a tangle of uniform nanowires and the other being granular in nature. Both AIHs undergo transformation to crystalline α-Fe by heat treatment at 600 °C. The nanowire AIH exhibits the hydrogen content of 0.10 wt%, while the granular AIH of 0.22 wt%. Their magnetic and thermal properties are accordingly different, and the non-diffusive hydrogen contributes to stability of AIHs. It is strongly suggested that, by use of quiescent reaction, iron-hydrogen clusters are formed and preserved at an early stage of precipitation reaction, and subsequently aggregated into novel AIHs, preventing α-Fe crystallization. Hence, the AIHs would be categorized as metastable hydrides stabilized with iron-hydrogen clusters. In addition, newly discovered quiescent reaction in aqueous solution, from which unprecedented AIHs are derived, sheds new light on fundamental and essential aqueous reaction.
Ultrafast microwave synthesis of rambutan-like CMK-3/carbon nanotubes nanocomposites for high-performance supercapacitor electrode materials
Authors: Yan Ke , Sun Xin , Ying Shu , Cheng Wen , Deng Yu , Ma Zhong , Zhao Yu , Wang Xinran , Pan Lijia , Shi Yi 
Published: April 2020

AbstractOrdered mesoporous carbon materials show great potential for electric double-layer supercapacitors because of their high specific surface area, designable pore structure, and tunable morphology. However, low graphitic crystallinity nature and poor contact between particles lead to their high inherent resistance, which limits the supercapacitance performance. Herein, we report on a hierarchically rambutan-morphological design of carbon composites with ordered mesoporous carbon as the core and carbon nanotubes as the shell, which significantly improve the electric contact between mesoporous carbon particles and promote the electrochemical performance. By an ultrafast microwave process in a household microwave heater under ambient condition, carbon nanotubes grow out from the pores of ordered mesoporous carbon and are dispersed on its surface like the whiskers of rambutan. As-synthesized ordered mesoporous carbon CMK-3/carbon nanotubes nanocomposites show significantly enhanced specific capacitance (315.6 F·g−1 at 1 A·g−1, as compared with 172.1 F·g−1 of CMK-3), high rate capability (214.6 F·g−1 at 50 A·g−1), and cycling durability (10,000 cycles, 99.32%). The structural design and microwave synthesis enable a facile preparation of the hybrid ordered mesoporous carbon CMK-3/carbon nanotubes nanocomposites, and show potential for easy and low-cost production of high performance electric double-layer supercapacitors materials.
IOUC-3DSFCNN: Segmentation of Brain Tumors via IOU Constraint 3D Symmetric Full Convolution Network with Multimodal Auto-context
Authors: Liu Jinping , Liu Hui , Tang Zhaohui , Gui Weihua , Ma Tianyu , Gong Subo , Gao Quanquan , Xie Yongfang , Niyoyita Jean Paul 
Published: April 2020

AbstractAccurate segmentation of brain tumors from magnetic resonance (MR) images play a pivot role in assisting diagnoses, treatments and postoperative evaluations. However, due to its structural complexities, e.g., fuzzy tumor boundaries with irregular shapes, accurate 3D brain tumor delineation is challenging. In this paper, an intersection over union (IOU) constraint 3D symmetric full convolutional neural network (IOUC-3DSFCNN) model fused with multimodal auto-context is proposed for the 3D brain tumor segmentation. IOUC-3DSFCNN incorporates 3D residual groups into the classic 3DU-Net to further deepen the network structure to obtain more abstract voxel features under a five-layer cohesion architecture to ensure the model stability. The IOU constraint is used to address the issue of extremely unbalanced tumor foreground and background regions in MR images. In addition, to obtain more comprehensive and stable 3D brain tumor profiles, the multimodal auto-context information is fused into the IOUC-3DSFCNN model to achieve end-to-end 3D brain tumor profiles. Extensive confirmatory and comparative experiments conducted on the benchmark BRATS 2017 dataset demonstrate that the proposed segmentation model is superior to classic 3DU-Net-relevant and other state-of-the-art segmentation models, which can achieve accurate 3D tumor profiles on multimodal MRI volumes even with blurred tumor boundaries and big noise.
A Two-Component regulatory system with opposite effects on glycopeptide antibiotic biosynthesis and resistance
Authors: Alduina Rosa , Tocchetti Arianna , Costa Salvatore , Ferraro Clelia , Cancemi Patrizia , Sosio Margherita , Donadio Stefano 
Published: April 2020

AbstractThe glycopeptide A40926, produced by the actinomycete Nonomuraea gerenzanensis, is the precursor of dalbavancin, a second-generation glycopeptide antibiotic approved for clinical use in the USA and Europe in 2014 and 2015, respectively. The final product of the biosynthetic pathway is an O-acetylated form of A40926 (acA40926). Glycopeptide biosynthesis in N. gerenzanensis is dependent upon the dbv gene cluster that encodes, in addition to the two essential positive regulators Dbv3 and Dbv4, the putative members of a two-component signal transduction system, specifically the response regulator Dbv6 and the sensor kinase Dbv22. The aim of this work was to assign a role to these two genes. Our results demonstrate that deletion of dbv22 leads to an increased antibiotic production with a concomitant reduction in glycopeptide resistance. Deletion of dbv6 results in a similar phenotype, although the effects are not as strong as in the Δdbv22 mutant. Consistently, quantitative RT-PCR analysis showed that Dbv6 and Dbv22 negatively regulate the regulatory genes (dbv3 and dbv4), as well as some dbv biosynthetic genes (dbv23 and dbv24), whereas Dbv6 and Dbv22 positively regulate transcription of the single, cluster-associated resistance gene. Finally, we demonstrate that exogenously added acA40926 and its precursor A40926 can modulate transcription of dbv genes but with an opposite extent: A40926 strongly stimulates transcription of the Dbv6/Dbv22 target genes while acA40926 has a neutral or negative effect on transcription of those genes. We propose a model in which glycopeptide biosynthesis in N. gerenzanensis is modulated through a positive feedback by the biosynthetic precursor A40926 and a negative feedback by the final product acA40926. In addition to previously reported control systems, this sophisticated control loop might help the producing strain cope with the toxicity of its own product. This work, besides leading to improved glycopeptide producing strains, enlarges our knowledge on the regulation of glycopeptide biosynthesis in actinomycetes, setting N. gerenzanensis and its two-component system Dbv6-Dbv22 apart from other glycopeptide producers.
Abdominal multi-organ auto-segmentation using 3D-patch-based deep convolutional neural network
Authors: Kim Hojin , Jung Jinhong , Kim Jieun , Cho Byungchul , Kwak Jungwon , Jang Jeong Yun , Lee Sang-wook , Lee June-Goo , Yoon Sang Min 
Published: April 2020

AbstractSegmentation of normal organs is a critical and time-consuming process in radiotherapy. Auto-segmentation of abdominal organs has been made possible by the advent of the convolutional neural network. We utilized the U-Net, a 3D-patch-based convolutional neural network, and added graph-cut algorithm-based post-processing. The inputs were 3D-patch-based CT images consisting of 64 × 64 × 64 voxels designed to produce 3D multi-label semantic images representing the liver, stomach, duodenum, and right/left kidneys. The datasets for training, validating, and testing consisted of 80, 20, and 20 CT simulation scans, respectively. For accuracy assessment, the predicted structures were compared with those produced from the atlas-based method and inter-observer segmentation using the Dice similarity coefficient, Hausdorff distance, and mean surface distance. The efficiency was quantified by measuring the time elapsed for segmentation with or without automation using the U-Net. The U-Net-based auto-segmentation outperformed the atlas-based auto-segmentation in all abdominal structures, and showed comparable results to the inter-observer segmentations especially for liver and kidney. The average segmentation time without automation was 22.6 minutes, which was reduced to 7.1 minutes with automation using the U-Net. Our proposed auto-segmentation framework using the 3D-patch-based U-Net for abdominal multi-organs demonstrated potential clinical usefulness in terms of accuracy and time-efficiency.
An overview of randomized controlled trials on endovascular treatment for chronic cerebrospinal venous insufficiency in multiple sclerosis patients
Authors: Simka Marian 
Published: April 2020

AbstractAbout ten years ago it was hoped that venous angioplasty for abnormal veins, primarily the internal jugular veins, will be a much awaited treatment for multiple sclerosis. Yet, a majority of randomized clinical trials on endovascular treatment for chronic cerebrospinal venous insufficiency did not reveal clinical efficacy of these procedures in multiple sclerosis patients. Still, a detailed analysis of these trials suggests that they were poorly designed, underpowered and endovascular techniques used were often far from being optimal. Nonetheless, even considering weak points of these trials, it can be concluded that venous angioplasty should not be used as a routine treatment modality in multiple sclerosis patients. Still, a possibility that some patients may benefit from endovascular treatment cannot be ruled out. This may concern patients at early stage of the disease and presenting with lesions that can easily be managed with balloon angioplasty. Therefore, we need more studies evaluating clinical efficacy of venous angioplasty in selected subgroups of multiple sclerosis patients. Importantly, it has already been demonstrated that venous angioplasty in multiple sclerosis patients is a safe procedure. Thus, also from an ethical point of view, such trials seem justifiable.
Geburtshilfliche Anästhesie während der SARS-CoV-2-Pandemie: Übersicht der Handlungsempfehlungen
Authors: Kranke Peter , Weibel Stephanie , Sitter Magdalena , Meybohm Patrick , Girard Thierry 
Published: April 2020

ZusammenfassungDie häufigsten menschlichen Coronaviren verursachen unkomplizierte Erkältungen. Drei dieser Viren jedoch lösen schwerere, akute Krankheiten aus: das Middle East Respiratory Syndrome (MERS) durch MERS-CoV, das schwere akute respiratorische Syndrom (SARS) durch SARS-CoV und COVID-19 durch SARS-CoV-2. Seitens der WHO wurde der aktuell währende Ausbruch als „global public health emergency“ eingestuft. Trotz aller Bestrebungen, das OP-Programm zu reduzieren und nicht zeitkritische operative Eingriffe zunächst abzusagen bzw. zu verschieben, sind weiter operative Eingriffe und anästhesiologische Interventionen jenseits der Intensivversorgung notwendig. Dies trifft im besonderen Maße für geburtshilfliche Eingriffe und die neuraxiale Analgesie im Rahmen des Spontanpartus zu. So wird der Kreißsaal mutmaßlich unverändert frequentiert werden und auch „elektive Sectiones“ werden weiterhin stattfinden müssen. Mittlerweile sind klinischer Verlauf und Outcome einiger COVID-19-Patientinnen mit bestehender Schwangerschaft bzw. peripartale Verläufe berichtet worden. Es liegen bereits zahlreiche Empfehlungen nationaler und internationaler Gremien in Bezug auf die Versorgung solcher Patientinnen vor. Einige dieser Empfehlungen sollen im Rahmen dieses Beitrages kursorisch dargelegt werden. Die Auswahl der Aspekte soll keineswegs als eine Form der Priorisierung angesehen werden. Die allgemeinen Behandlungsgrundsätze im Umgang mit COVID-19-Patientinnen und die Handlungsempfehlungen zur intensivmedizinischen Therapie behalten dabei auch für schwangere und postpartale Patientinnen Gültigkeit. Insofern ergeben sich naturgemäß erhebliche Redundanzen, und nur wenige Aspekte treffen streng bzw. ausschließlich auf das Kollektiv geburtshilflicher Patientinnen zu. Zusammenfassend muss zum gegenwärtigen Zeitpunkt konstatiert werden, dass in der geburtshilflichen Anästhesie zunächst die allgemeinen Versorgungsempfehlungen gelten, die auch für Non-COVID-19-Patientinnen geltengültig sind. Gleichwohl ergeben sich durch die besonderen Vorgaben seitens der Hygiene bzw. des Infektionsschutzes besondere Umstände, die bei der Versorgung schwangerer Patientinnen berücksichtigt werden sollten. Diese betreffen neben medizinischen Fragen im Besonderen auch Fragen der Logistik in Hinblick auf eine räumliche Separierung, die Personalvorhaltung und materielle Ressourcen.
SARS-CoV-2/COVID-19: Empfehlungen zu Diagnostik und Therapie
Authors: Bein Berthold , Bachmann Martin , Huggett Susanne , Wegermann Petra 
Published: April 2020

ZusammenfassungDer Übersichtsartikel ist als praktische Handreichung für alle gedacht, die COVID-19-Patienten behandeln bzw. in nächster Zeit behandeln werden, und fasst das derzeit verfügbare Wissen zu Diagnostik und Therapie zusammen. Zusätzlich werden auch neue und experimentelle Therapien bewertet, soweit dazu zumindest Einzelfallberichte vorliegen.
Value, Strengths, and Challenges of e-Learning Modules Paired with the Flipped Classroom for Graduate Medical Education: A Survey from the National Neonatology Curriculum
Authors: Gray Megan M. , Dadiz Rita , Izatt Susan , Gillam-Krakauer Maria , Carbajal Melissa M. , Falck Alison J. , Bonachea Elizabeth M. , Johnston Lindsay C. , Karpen Heidi , Vasquez Margarita M. , Chess Patricia R. , French Heather 
Published: April 2020

Abstract
Objective This study aimed to determine the value, strengths, and challenges of implementing an e-learning based flipped classroom (FC) educational modality as part of the standardized physiology National Neonatology Curriculum (NNC), created for neonatal-perinatal medicine (NPM) fellow learners and faculty educators.
Study Design This is a cross-sectional study of NPM fellows and faculty educators who utilized at least one of the e-learning based NNC FC respiratory physiology programs between May and September 2018. Participants were surveyed anonymously regarding their experiences participating in the NNC, including measures of preparation time. A combination of descriptive statistics and proportion comparisons were used for data analysis.
Results Among 172 respondents, the majority of fellow and faculty respondents reported positive attitudes toward the educational content and case discussions, and the majority supported national standardization of NPM physiology education (92%). Fellows reported greater preclass preparation for their FC compared with previous didactic lectures (30–60 vs. 0–15 minutes, p < 0.01). Faculty facilitators reported less preparation time before facilitating a FC compared with the time required for creating a new didactic lecture (median: 60 vs. 240 minutes, p < 0.01). Both fellows and faculty respondents preferred the FC approach to traditional didactics, with fellows showing a greater degree of preference than faculty (68 vs. 52%, respectively, p = 0.04).
Conclusion Fellows and faculty educators supported the FC learning, reporting peer-to-peer learning, and the establishment of a learning community which promotes adult learning and critical thinking skills. A national physiology curriculum creates equitable and engaging educational experiences for all NPM fellows while reducing individual program burden of content creation. Our findings further supported the development of an NNC using a flipped classroom modality.
Protecting Labor and Delivery Personnel from COVID-19 during the Second Stage of Labor
Authors: Palatnik Anna , McIntosh Jennifer J. 
Published: April 2020

The novel coronavirus disease 2019 (COVID-19) is spreading fast and is affecting the clinical workers at much higher risk than the general population. Little is known about COVID-19 effect on pregnant women; however, the emerging evidence suggests they may be at high risk of asymptomatic disease. In light of projected shortage of personal protective equipment (PPE), there is an aggressive attempt at conservation. In obstetrics, the guidelines on PPE use are controversial and differ among hospitals, globally, as well as nationally. The centers for disease control and prevention (CDC) recommend using N95 respirators, which are respirators that offer a higher level of protection instead of a facemask for when performing or present for an aerosol-generating procedures (AGP). However, the second stage of labor is not considered an AGP. The second stage of labor can last up to 4 hours. During that time, labor and delivery personnel is in close contact to patients, who are exerting extreme effort during and frequently blow out their breath, cough, shout, and vomit, all of which put the health care team at risk, considering that COVID-19 transmission occurs through aerosol generated by coughing and sneezing. The CDC and the American College of Obstetricians and Gynecologists (ACOG) do not provide clarification on the use of N95 during the second stage. We recommend that labor and delivery personnel have the utmost caution and be granted the protection they need to protect themselves and other patients. This includes providing labor and delivery personnel full PPE including N95 for the second stage of labor. This is critical to ensure the adequate protection for health care workers and to prevent spread to other health care workers and patients.
Key Points
Multifunctional composites for elastic and electromagnetic wave propagation
Authors: Kim Jaeuk , Torquato Salvatore 
Published: April 2020

Significance
We establish accurate microstructure-dependent cross-property relations for composite materials that link effective elastic and electromagnetic wave characteristics to one another, including effective wave speeds and attenuation coefficients. Our microstructure-dependent formulas enable us to explore the multifunctional wave characteristics of a broad class of disordered microstructures, including exotic disordered “hyperuniform” varieties, that can have advantages over crystalline ones, such as nearly optimal, direction-independent properties and robustness against defects. Applications include filters that transmit or absorb elastic or electromagnetic waves “isotropically” for a range of wavelengths. Our findings enable one to design multifunctional composites via inverse techniques, including the exterior components of spacecraft or building materials, heat sinks for CPUs, sound-absorbing housings for motors, and nondestructive evaluation of materials.
Media political parallelism and political agenda setting in Italy
Authors: Seddone Antonella 
Published: April 2020

Abstract
The issue of whether and how political parallelism could play a role in the agendadynamics between media and politics is relevant. Yet, this issue has been exploredonly rarely and the findings are unclear. Using Italy as an illustration, this studyinvestigates the interactions between parallel media and the political agenda between2006 and 2011. Based on the analysis of a longitudinal dataset, this investigation aimsto assess whether and to what extent parallel media coverage may have affected thepolitical agenda concerning two policy issues: (i) reform of the labor market and (ii) theaccess of regular migrants to Italian citizenship. Specifically, the media’s attention tothese two policy issues will be analyzed based on the parliamentary questions (PQs)addressed by members of Parliament (MPs).
The impact of simultaneous-interpreting prosody on comprehension
Authors: Lenglet Cédric , Michaux Christine 
Published: April 2020

AbstractDoes the particular prosody of simultaneous interpreting have an impact on comprehensibility? This paper presents an experiment that sought to answer this question. Two groups of listeners (47 with relevant contextual knowledge about the subject-matter of the speech and 40 with less contextual knowledge) listened to the interpretation into French of a 20-minute lecture in German under two conditions (the actual interpretation and a read-aloud rendition of the transcript of the interpretation by the same interpreter) and answered comprehension questions. The prosodic features of the two conditions were analysed, and differences regarding the temporal organisation of speech, disfluencies, pitch register and the interface between prosody and syntax emerged. Simultaneous interpreting was found to be more monotonous, to contain a larger number of short and long silent pauses, more hesitations (“euh”) and more non-syntactic pauses as well as to have a more irregular speech rate. The read-aloud version was livelier, with more medium-length silent pauses and almost no hesitation. Results of the comprehension questionnaire do not demonstrate that interpreting-specific prosodic features affect comprehensibility to a significant extent. This is consistent with professional norms of interpreting in specialised conferences, where verbal aspects have priority over non-verbal ones.
The role of verbal working memory in L2 sentence comprehension
Authors: Kerz Elma , Wiechmann Daniel 
Published: April 2020

AbstractConsiderable variability has been observed in sentence comprehension abilities in both native speakers and second language (L2) learner populations. While it has long been established that, in native speakers, this variability is closely linked to individual differences (IDs) in verbal working memory (vWM), previous research on the role of vWM in L2 sentence comprehension has produced mixed results. Moreover, there is an accumulating body of evidence demonstrating that the relationship between vWM and native language comprehension abilities is mediated by language experience. However, to our knowledge, until now, no attempt has been made to integrate language experience measures into the vWM-L2 sentence comprehension relationship. The goal of the present study is twofold: (1) to determine whether and to what extent vWM – as gauged by a reading span (RSPAN) task – correlates with IDs in two proxy estimates of L2 experience and (2) to investigate the effects of vWM on L2 comprehension of three different types of complex sentences. Thirty-four German advanced learners of English participated in this study. Significant positive correlations were found between the RSPAN scores and both proxy estimates of L2 experience. Mixed-effects modeling revealed that vWM exerted a significant effect on L2 sentence comprehension that was not modulated by sentence type. Taken together, these results provide additional evidence in support of the involvement of vWM in L2 sentence comprehension and, to our knowledge, first evidence for the contribution of L2 experience to RSPAN task performance.