bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and Genetic Analysis of Digenic Muscular Dystrophy due to SRPK3 and TTN Variants in Two Siblings
Authors: Sharkova Inna , Borovikov Artem , Konovalov Fedor , Nefedova Maria , Shchagina Olga , Kutsev Sergey , Murtazina Aysylu 
Published: December 2024

ABSTRACTWe present a family with two male siblings diagnosed with a newly described digenic myopathy, involving likely pathogenic loss‐of‐function variants in the SRPK3 and TTN genes: hemizygous p.(Pro68ArgfsTer55) and heterozygous p.(Trp14174Ter), respectively. Both siblings experienced prenatal disease onset, characterized by weak fetal movements, but showed significant clinical improvement over two last years of our follow‐up. Key features included early onset, delayed motor development, and prominent axial and proximal weakness, while adult variants' carriers remained asymptomatic, without any myopathic or cardiac manifestations. Lower limb MRI revealed distinctive abnormalities, with different patterns between the siblings: the older brother showed more pronounced involvement of the thigh muscles, while the younger brother exhibited greater changes in the lower leg muscles. Given the early stage of the disease in our patients and the initial changes observed on MRI, we suggest that the semitendinosus and vastus lateralis muscles are primarily involved at the thigh level in SRPK3/TTN‐myopathy. This case highlights the importance of considering digenic inheritance in neuromuscular disorders and underscores the necessity of comprehensive genetic analysis in similar cases.
Primary Stability of Dental Implants in Human Jawbones: Experiments & FE Analyses
Authors: Wili Patrik , Rauber Cedric , Saade Amal , Bliggenstorfer Salomé , Ramirez‐Garmendia Valentina , Schweizer Ramon , Irastorza‐Landa Ainara , Chappuis Vivianne , Zysset Philippe 
Published: December 2024

ABSTRACTObjectivesPrimary stability (PS) is a key factor for promoting osseointegration and long‐term success of dental implants particularly for immediate loading protocols. Beyond the current assessments of PS, an accurate pre‐operative evaluation of PS would contribute to the improvement of surgical planning and treatment outcome. This study used biomechanical testing and homogenized finite element (hFE) analysis to objectively measure PS in the laboratory, and digitally estimate PS from prior μCT reconstructions.Material and MethodsThirty‐five bone samples extracted from the jaws of two donors were examined. Twenty‐two were finally evaluated for PS. After scanning of the samples with μCT, implants were inserted by two experienced surgeons, and various metrics such as μCT‐based bone volume fraction (BV/TV), insertion torque (IT), and resonance frequency analysis (RFA) were assessed to determine PS. Mechanical tests were conducted to measure ultimate force (UFexp) as an objective indicator of PS while the hFE simulations were performed to estimate this same ultimate force (UFsim).ResultsHigher correlation was found between UFsim and UFexp (R2 = 0.85) than between BV/TV and UFexp (R2 = 0.61), IT and UFexp (R2 = 0.50), and RFA and UFexp (R2 = 0.38). All variables demonstrated a statistically significant linear correlation with UFexp (p < 0.01).ConclusionUFsim turns out to be a more reliable and objective indicator of PS than IT and RFA. The hFE analysis requires prior μCT reconstructions and is currently limited by numerical convergence problems. Despite these limitations, pre‐operative hFE analysis emerges as a promising tool with a higher accuracy for estimation of PS than state of care techniques.
Reproductive Toxicity Induced by Serotonin‐Norepinephrine Reuptake Inhibitors: A Pharmacovigilance Analysis From 2004 to 2023 Based on the FAERS Database
Authors: Xi Yujia , Bao Zhuocheng , Guo Qiang , Wang Jingqi , Jing Zhinan , Di Jingkai , Yang Ke 
Published: December 2024

ABSTRACTAimSerotonin‐norepinephrine reuptake inhibitors (SNRIs) have been extensively utilized for the treatment of depression and anxiety disorders. Clinical trials and real‐world data suggest that SNRIs may cause reproductive toxicity. To comprehensively assess this association, we conducted a pharmacovigilance study.MethodsWe utilized various disproportionality analysis algorithms, including reporting odds ratio (ROR), proportional reporting ratio (PRR), bayesian confidence propagation neural network (BCPNN), and multi‐item gamma poisson shrinker (MGPS), to assess the significance of reproductive toxicity‐related adverse events (AEs) reported to FDA Adverse Event Reporting System (FAERS) from January 2004 to December 2023, with subgroup analysis conducted by sex and age.ResultsDuloxetine and venlafaxine were associated with 14 and 25 AE signals related to reproductive toxicity, respectively, with erectile dysfunction (ED) and retrograde ejaculation identified as shared important medical events (IMEs). ED had the highest reporting frequency, strongest in venlafaxine‐treated patients under 45 years (ROR 4.34, PRR 4.33, IC 2.09, EBGM 4.25). Retrograde ejaculation was newly identified. With decreasing incidence, venlafaxine's median ED onset was 122.5 days and duloxetine's 38 days.ConclusionOur study provides evidence through an extensive analysis of the large‐scale real‐world FAERS database, aiding healthcare professionals in mitigating, and prioritizing SNRI‐related reproductive toxicity AEs.
Consumer reactions to multiple and single health warnings on static alcohol ads: A factorial survey experiment with a convenience sample of adults in Ireland
Authors: Filipova Vania , Hooper Daire , Kenny Patrick 
Published: December 2024

AbstractIntroductionAs part of several measures to inform consumers about the health risks of alcohol, the Irish Government signed into law the Public Health (Alcohol) Act 2018, with Section 13 requiring the implementation of multiple health warnings in all alcohol ads. Although health warnings on product labels have been subject to intensive political discussion and academic research, health warnings in alcohol ads have received little attention.MethodsA between‐subject factorial survey experiment was conducted with a convenience sample of adults in Ireland (n = 932) to compare single‐text, multiple‐text and shocking image‐and‐text health warnings displayed on two types of static alcohol ads—an ad with social imagery featuring people drinking alcohol and an ad featuring only the alcohol product. Believability of health warnings, negative emotions, perceived risks of alcohol use and self‐efficacy to drink less were measured after viewing each alcohol ad with or without health warnings.ResultsSingle‐text health warnings, with and without shocking imagery, were more effective in increasing negative emotions than multiple‐text health warnings (p ≤ 0.001), whereas multiple‐text warnings were found to be more believable than single‐text warnings (p ≤ 0.001). No significant effects were found on perceived risks of alcohol use and self‐efficacy to drink less (p > 0.05). The warnings did not differ across demographic groups and the type of alcohol ads on all outcomes (p > 0.05).Discussions and ConclusionsA single health warning emphasising cancer risk could be a useful starting point for policymakers when implementing health warnings in alcohol ads.
Alcohol consumption and mortality among Canadian drinkers: A national population‐based survival analysis (2000–2017)
Authors: Clay James M. , Callaghan Russell C. , Sherk Adam , Naimi Timothy S. , Stockwell Tim , Asbridge Mark 
Published: December 2024

AbstractIntroductionAlcohol contributes significantly to global disease burden. Over 50 countries, including Canada, have established low‐risk drinking guidelines to reduce alcohol‐related harm. Canada's Guidance on Alcohol and Health (CGAH) was released in 2023. This study examines the relationship between weekly alcohol consumption, CGAH risk zones and mortality patterns among Canadian drinkers aged 15 and older.MethodsA retrospective cohort study was conducted using data from three cycles of the national, population‐based Canadian Community Health Survey (2000–2006) linked to mortality data up to 2017. The sample included 145,760 respondents aged 15 and older who reported alcohol consumption in the past week. Average weekly alcohol consumption was assessed using the Timeline Followback method (i.e., 7‐day recall). Outcomes included all‐cause mortality, alcohol‐related mortality and mortality from conditions with an alcohol‐attributable fraction ≥15%.ResultsAlcohol consumption was significantly positively associated with increased risks of all‐cause (hazard ratio = 1.01, p < 0.001), alcohol‐related (hazard ratio = 1.01, p = 0.001) and alcohol‐attributable fraction‐related mortality (hazard ratio = 1.02, p < 0.001). Each additional standard drink per week raised mortality risk, with women experiencing a greater increase in risk compared to men.Discussion and ConclusionThe findings support the CGAH recommendations, highlighting the importance of lower alcohol consumption limits to reduce health risks. Public health efforts should focus on increasing awareness and adherence to these guidelines, particularly among women who face greater mortality risks at higher consumption levels. Ongoing monitoring of alcohol consumption is critical for tracking and evaluating low‐risk drinking guideline effectiveness in reducing alcohol‐related harm.
Task‐specific and seasonal differences in individual nutritional status of red wood ant workers
Authors: Iakovlev Ivan K. , Reznikova Zhanna I. , Tiunov Alexei V. 
Published: December 2024

Abstract
Diet plays a crucial role in caste differentiation and division of labour in ants, but relationships between behavioural specialization and the nutritional status of workers in monomorphic species remain understudied.
We used the red wood ant Formica aquilonia, a key species of forest communities in North Eurasia, to examine whether (i) nurses are fatter than foragers; (ii) task groups collected on the nest surface, ground surface and trees have different fat reserves; and (iii) task groups differ in the diet and trophic level.
Higher fat content in nurses including sunbathing workers compared to foragers was shown by abdomen: thorax dry mass, C:N ratio and δ13C values in the abdomen and thorax. Colony fat reserves were minimal in summer and maximum in autumn, especially in nurses.
Ground foragers restoring the foraging territory in spring showed signs of starvation according to the thoracic δ15N values. Nest guards and foragers were similarly lean in summer. Tree foragers collecting honeydew were leaner than ground foragers (hunters) in autumn.
Workers were of similar trophic level. Differences in crop content between nurses and foragers were indicated by the δ15N value in the abdomen.
Our study suggests that the seasonal dynamics of energy reserves and nutritional differences between task groups are linked to the annual life cycle of the colony, contributing to its reproductive success.
Contribution of Interventionist Dynamic Assessment to the Acquisition of Modal Verbs: The Moderating Role of Field (In)dependence and Working Memory
Authors: Karimpour Sedigheh , Kargar Behbahani Hossein 
Published: December 2024

ABSTRACTAs an alternative to conventional instruction and evaluation methods, dynamic assessment aims to promote language learning by utilising an interactive approach. As a subset of dynamic assessment, the interventionist approach to dynamic assessment focuses on mediation from implicit to explicit. In spite of its central role in language learning and assessment, the interventionist dynamic assessment has received less attention in empirical research. To fill part of the gap, this study examined the contributions of interventionist dynamic assessment to the acquisition of modal verbs treating working memory and field (in)dependence as two moderating variables. Two intact classes of experimental and control groups, each with 30 subjects, took part in this quantitative quasi‐experimental research. The experimental group received an interventionist dynamic assessment based on the target linguistic feature, while the control group received a traditional presentation‐practice‐production mode of instruction. The findings of the study revealed that while at the onset, both groups performed similarly, the experimental group outperformed the control group on the posttest, as determined by the between‐subjects ANOVA. The difference between pretest and delayed posttest scores was also significant, corroborating the effectiveness of the treatment on the acquisition of the linguistic form. The study findings highlighted how interventionist dynamic assessment along with a high working memory and a field‐independence trait influence the acquisition of linguistic features. The study has multiple implications for EFL learners and teachers.
Warm Temperature is Associated With Reduced Body Mass and Diversification Rates While Increasing Extinction Risks in Cold‐Adapted Seabirds
Authors: Xiong Ying , Fan Liqing , Chang Yongbin , Xiao Hongtao , Lei Fumin 
Published: December 2024

ABSTRACTAnthropogenic rapid warming has caused decreases in richness and body mass of birds following the metabolic theory of ecology; yet, the pervasiveness of these shifts remains controversial among different taxa. Here, by combining phylogenetic methods and fossil data, we synthesized spatial patterns of richness and body mass for 328 seabird species belonging to two groups: Procellariimorphae (PM) and non‐Procellariimorphae (NPM). We found that the relationship between body mass and richness, as well as diversification rate, exhibits distinct patterns in these two groups. Ancestral state reconstruction analyses indicate that smaller PM, as opposed to NPM seabirds, evolved in warmer waters from larger ancestors and exhibited a slower diversification rate. Different ancestral climatic origins explain the reduced influence of environmental factors on richness patterns among PM compared to NPM seabirds. Furthermore, whereas NPM seabirds in high latitudes face a high extinction risk, warmer sea temperatures positively correlate with a high extinction risk among PM seabirds. Our results indicate that PM seabirds, evolving from cold waters, have reduced body mass and diversification rate, making them more vulnerable to warmer temperature.
Does Resource Industry Dependence Undermine Urban Resilience? Evidence From China
Authors: Wang Qingxi , Xin Yueji , Tian Zhihua , Hu An , Liu Ye 
Published: December 2024

ABSTRACTThis study empirically investigates the causal relationship between resource industry dependence and urban resilience from three perspectives: ecological, economic, and social, contributing to the resource curse theory and the sustainable development of resource‐dependent cities. We use the entropy method to establish an urban resilience index system to measure the resilience of 269 Chinese cities from 2000 to 2019, and construct a two‐way fixed‐effects model to test the impact of resource industry dependence on urban resilience. The results show that resource industry dependence impairs urban resilience, and this finding remains robust to the estimation using an instrumental variable approach. Moreover, mechanism tests show that resource industry dependence undermines urban resilience by inhibiting industrial structural upgrading and hindering green technological innovation. We further categorize urban resilience into ecological resilience, economic resilience, and social resilience, and find that resource industry dependence has a more significant negative impact on urban ecological resilience and social resilience than on economic resilience. Our investigations suggest that cities should develop strategies based on their unique endowments to reduce resource dependence, improve urban resilience by strengthening industrial systems and promoting innovation, and achieve sustainable economic development.
“It's like it's the old boys club”—the age‐related experiences of diverse older women living with HIV: A scoping review and consultative exercise
Authors: Kokorelias Kristina M. , Su Esther , Brown Paige , McKinlay Stuart , Flanagan Ashley , Walmsley Sharon , Zhabokritsky Alice , Lee Katie , Sirisegaram Luxey 
Published: December 2024

AbstractObjectivesHIV is often under‐recognized in older individuals, particularly women, despite a significant number of new cases being diagnosed in those aged >50 years. This review aimed to understand the age‐related experiences and challenges faced by women aged ≥50 years living with HIV through an intersectional perspective.MethodsWe conducted a systematic scoping review using the framework by Arksey and O'Malley, refined by Levac, Colquhoun, and Peters, and informed by a Sex‐ and Gender‐Based Analysis Plus (SGBA+) approach. The research questions were developed in consultation with community advisory stakeholders. A comprehensive search strategy was used, targeting categories related to ‘aged,’ ‘HIV,’ and ‘women’ based on scoping review and Peer Review of Electronic Search Strategies guidelines. We included peer‐reviewed studies where at least 50% of participants were women aged ≥50 years and living with HIV, focusing on their age‐related experiences in health or social contexts. Two independent reviewers applied inclusion criteria through a two‐level screening process. Data extraction included details on publication type, study characteristics, participant recruitment, and results. Findings were synthesized and presented to a stakeholder advisory committee for additional insights. Stakeholder input from an advisory committee was incorporated into the findings, providing additional context and enhancing the interpretation of the results.ResultsThe review included 21 articles. Key findings revealed the intersectional challenges faced by women aged ≥50 years living with HIV, such as stigma, emotional resilience, social support networks, and health management strategies. These findings highlight the complex interplay of factors influencing their lives, from concerns about sharing HIV status to strategies for managing health. The review also identified research gaps and underscored the need for comprehensive studies on the intersectional dynamics affecting health outcomes in this population.ConclusionsThis review underscores the complex challenges and strengths of women aged ≥50 years living with HIV, emphasizing the need for tailored interventions and support services that recognize their intersecting identities and unique needs. Addressing these issues is essential for ensuring equitable access to care and fostering resilience within this community.
Effect of additive content on the microstructure and room‐temperature and high‐temperature mechanical properties of Si3N4 ceramics
Authors: Du Songmo , Li Fei , Zhang Jie , Chen Zhanglin , Zhang Shijia , Zhao Shuo , Zhao Dengke , Fan Binbin , Chen Kexin , Liu Guanghua 
Published: December 2024

AbstractSi3N4 ceramics with uniform grain size distribution were fabricated using spark plasma sintering method and post‐heat treatment. The effect of sintering additive content on the grain growth and room‐temperature and high‐temperature mechanical properties of Si3N4 ceramics were studied. By modulating the competitive growth of β‐Si3N4 grains along the basal and the prism planes, the grains in Si3N4 ceramics were homogeneous. The room‐temperature and high‐temperature flexural strength of the samples after post‐heat treatment were tested. At temperature above 1300°C, the samples with lower sintering additive content exhibit higher strength.
AQUABEAM robotic system use‐results survey: Aquablation for the treatment of lower urinary tract symptoms due to benign prostatic hyperplasia in the Japanese Population
Authors: Hinata Nobuyuki , Fujisawa Masato , Yamaguchi Raizo , Katsura Daiki , Kitano Hiroyuki , Sekino Yohei , Yoshioka Kunihiko , Koike Shin , Odagaki Yu , Ozawa Yu , Aoki Keisuke , Miyauchi Toshihide , Watanabe Susumu , Barber Neil , Elterman Dean , Afshar Ali , Saito Keisuke , Ide Hisamitsu , Horie Shigeo 
Published: December 2024

ObjectivesTo evaluate the safety, efficacy, and patient‐reported outcomes of Aquablation therapy using the AQUABEAM Robotic System for the treatment of lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) in a Japanese population.MethodsThis post‐market use‐results survey included 103 Japanese men with BPH who underwent Aquablation across five centers with previously Aquablation naïve physicians. Data were collected at baseline, during the procedure, at discharge, and at 3 and 6 months post‐procedure. Key outcomes included International Prostate Symptom Score (IPSS), quality of life (QoL), uroflowmetry parameters, and adverse events.ResultsThe mean age of patients was 71.1 years, and the average prostate size was 82.3 mL. At 6 months, the mean IPSS significantly improved from 18.1 ± 9.0 to 6.1 ± 5.0 (p < 0.0001), and QoL scores improved from 4.9 ± 1.3 to 1.8 ± 1.3 (p < 0.0001). Uroflowmetry showed a significant increase in Qmax from 8.3 ± 4.4 to 15.5 ± 7.8 mL/s (p < 0.0001) and a decrease in post‐void residual volume (PVR) from 85.6 ± 107.2 to 43.3 ± 60.0 mL (p = 0.0006). At the 30‐day primary safety endpoint, there were no reported adverse events of pad‐use incontinence, erectile dysfunction, or ejaculatory dysfunction reported, and no device‐related serious adverse events were reported. One subject (0.97%) experienced a Clavien–Dindo grade 3 adverse event.ConclusionsAquablation therapy using the AQUABEAM Robotic System is a reproducible, safe, and effective treatment for Japanese men with BPH, providing significant improvements in LUTS and QoL with a favorable safety profile.
Characteristics of paracetamol poisoning in a local health network and consistency of hospital management with national guidelines
Authors: Hurley Simon P. , Horwood Chris , Mallon Jake , Mangoni Arduino A. , Inglis Joshua M. 
Published: December 2024

AbstractThe management of paracetamol poisoning in our local health network and consistency with national guidelines is unclear. We conducted a 4‐month retrospective study of all paracetamol poisonings identified in two South Australian hospitals. Most presentations were deliberate self‐poisoning (90.7%) with immediate‐release formulations (88.0%). Although most were managed in accordance with national guidelines, there were deficiencies in documentation of the poisoning details and patient weight as well as cases of underdosing of the antidote. Quality improvement initiatives are needed.