bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lumbar Sagittal Alignment May Be a Good Predictor for the Lumbar Spine Degeneration
Authors: Xu Xingping , Guo Chao , Chen Changwei , Tang Yong , Wang Fusheng , Wang Yangsheng 
Published: August 2020

Abstract
BackgroundIncreasing attention has been focused on (modic changes and end plate defect) MC&ED as a potential role in the etiopathogenesis of lumbar degeneration. The precise mechanism leading to progression of MC&ED is lacking. Some scholars thought lumbar sagittal alignment might be a key influence factor, but without enough clinical evidence. Hence, we investigated how lumbar sagittal alignment influences MC&ED.MethodsNinety-six asymptomatic or symptomatic patients with Modic changes or end plate defect were retrospectively recruited in this study from August 2016 to December 2018. MC&ED were observed in 76 patients and not observed in 20 patients, representing two groups for comparison. The lumbar sagittal parameters were measured, including lumbar lordosis (LL), pelvic incidence (PI), sacral slope (SS), and pelvic tilt (PT). The lumbar lordosis index(LLI) and idea LL were then calculated. Clinical outcomes were assessed using a visual analog scale(VAS) and an Oswestry Disability Index (ODI) before and after an operation.ResultsThere were no significant difference in the distribution of demographic and baseline clinical variables between both groups. Mean age and BMI showed significant difference between both groups (P < 0.05). There were significant correlations between LL, LLI, Loss of LL, and Level 1 (r = 0.281, 0.230, and 0.284, P < 0.05) Also, PI, PT were significantly correlated with Level 4 (r = 0.249, 0.202, P < 0.05). Compared with presurgery scores, an improvement was seen in postoperative VAS and ODI scores (P < 0.05). Further, the postoperative scores at 24 months in the without Modic or end plate defect group showed greater improvements compared with the with Modic or endplate defect group (P < 0.05).ConclusionThis analysis indicated that maintaining lumbar sagittal alignment was related to a lower risk of Modic changes in patients with the spinal degenerative disease. The lumbar sagittal alignment might be a factor that influenced the posterior inclination of the pelvis in symptomatic lumbar disease.
Surgical Technique and Outcome of Joint Sparing Limb Salvage Surgery by Three-dimensional-printed Prothesis for Children With Osteosarcoma in Distal Femur
Authors: Cai Tao , Zhang Chunlin , Zhang Lei , Zhu Kunpeng , Hu Jianping , Zhan Taichen 
Published: August 2020

Abstract
Purpose The purpose of this study was to introduce the surgical technique and functional outcome of joint-sparing limb salvage surgery with metaphyseal osteotomy by dependent design of three-dimensional printed prothesis for children with osteosarcoma in distal femur.Methods Between 2012 to 2019, we performed twelve joint sparing limb salvage surgeries (JSLSS) with metaphyseal osteotomy for the children of osteosarcoma in the distal femur with our dependent design of 3D-printed guided plate and prothesis. The clinical assessment including resection margin, limb-length discrepancy, orthopaedic complications and functional outcome would be analyzed.Results The mean operation time for JSLSS was 107.6 minutes and the average blood loss was 194.5ml with the dependent design of 3D-printed prosthesis. With the assistance of guide plate, the mean margin of the osteosarcoma from the epiphyseal plate was 1.6 cm and the mean limb-length discrepancy was 2.2 cm with maximum follow-up period of seven years (mean 45.3 months, range 12-84 months). All the patients could bend their knee through >90° flexion, achieved similar results for ROMs in 6DOF during gait compared with normal data of Chinese knees, and the mean MSTS score was 94.7 for the patients with JSLSS. One patient had a superficial infection and there was one patient of local recurrence happened during the follow-up with the necrosis rate less than 90% by preoperative chemotherapy. None aseptic loosening happened in distal femur for the patients in this group with dependent design of 3D-printed prosthesis.Conclusion Joint-sparing limb salvage surgery by metaphyseal osteotomy with the dependent design of 3D-printed prosthesis and guide plate would be a good choice for the children with osteosarcoma in distal femur.
Comparison of the Clinical Effect of Simple Nucleotomy for the Treatment of Single-segment Lumbar Disc Herniation Using a Microscope and Percutaneous Transforaminal Endoscope
Authors: dece Kong , Chen Tianning , Zheng Xinhui , Liu Shuyi , Yang Tieyi , Zhang yan , Shao Jin 
Published: August 2020

Abstract
Objective: To compare the clinical effect of single-segment lumbar intervertebral herniation with simple nucleotomy using a microscope and percutaneous transforaminal endoscope. Methods: From May 2016 to October 2018, a total of 120 patients who underwent simple nucleotomy in our hospital for single-segment lumbar disc herniation were selected. According to the surgical methods, they were randomly divided into 2 groups: the microscopical treatment group included 60 cases, aged 28-65 years, with an average of 48.73 ± 12.35 years; the percutaneous transforaminal endoscopic treatment group included 60 cases, aged 29-67 years, with an average of 49.36 ± 11.76 years. The differences in the JOA score, ODI index, VAS score, serum CPK content, operation time, intraoperative bleeding, incision length, intraoperative X-ray fluoroscopy, hospital stay, and 1-year recurrence (secondary revision surgery) between the two groups were analysed. Results: On the second day after surgery, the serum CPK contents were higher than before surgery in both groups (P<0.01), and the CPK content was higher in the microscopical treatment group than in the percutaneous endoscopic treatment group (P<0.01). The JOA score at 1 year after surgery was significantly higher than before surgery, and the ODI index and VAS score at 1 year after surgery were significantly lower than before surgery in each group (P<0.01). Compared with the percutaneous endoscopic treatment group, the intraoperative bleeding and the lengths of incision and hospital stay were significantly increased (P<0.01) and the operation time (P<0.05) and number of X-ray fluoroscopies during the operation (P<0.01) were significantly reduced in the microscopic treatment group. At 1 year after surgery, compared with the microscopic treatment group, 2 cases of complications were found in the percutaneous endoscopic surgery group. One case was a postoperative recurrence, and the other one case was endoscopic operative failure, which received a second revision surgery using a microscope. Conclusion: Simple nucleotomy for the treatment of single-segment lumbar intervertebral herniation has good clinical effects using a microscope and percutaneous transforaminal endoscope. The percutaneous transforaminal endoscope has the advantages of less trauma, less bleeding, and shorter hospital stay, while the microscope has the advantages of shorter operation time and less intraoperative X-ray fluoroscopy.
Characterization of Fatal Injuries in Oil and Gas Industry-Related Helicopter Accidents in the Gulf of Mexico, 2004–2014
Authors: Yeoman Kristin , O'Connor Mary B , Poplin Gerald , Sochor Sara 
Published: August 2020

Abstract
Background: Transportation events are the most common cause of offshore fatalities in the oil and gas industry, and helicopter accidents comprise the majority of transportation events. Little is known about injury distributions in civilian helicopter crashes, and helicopter passengers continue to die in crashes that are considered survivable. Knowledge of injury distributions could focus research and recommendations for injury prevention and post-crash survival. The objective of this study was to describe the distribution of injuries among fatalities in oil and gas industry-related helicopter accidents in the Gulf of Mexico. Methods: Pilots and passengers of accidents during 2004–2014 were identified from government records and media reports. Autopsy reports were requested from the responsible jurisdictions. Each documented injury was coded using the Abbreviated Injury Scale (AIS), and frequency and proportion of injuries by AIS body region and severity were calculated. Injuries were also categorized into more detailed body regions to identify focused areas of prevention and control. Results: Minor injuries were most prevalent in the face, neck, upper and lower extremities, and abdomen. Serious or worse injuries were most prevalent in the thorax, spine, head, and external/other regions. The most frequent injuries by detailed body regions were thoracic organ, thoracic skeletal, abdominal organ, and leg injuries. Drowning occurred in 37.1% of victims.Conclusions: The proportion of minor, moderate, and severe or worse injuries differed by body region, and the most frequent injuries occurred in the thorax and lower extremity regions.
60-day survival of critically ill COVID-19 first comers
Authors: Lang Corinna N. , Zotzmann V. , Schmid B. , Berchtold-Herz M. , Utzolino S. , Biever P.M. , Pottgießer T. , Duerschmied D. , Bode C. , Wengenmayer T. , Staudacher D.L. 
Published: August 2020

Abstract
Background: Germany reported sufficient intensive care unit (ICU) resources throughout the first wave of coronavirus disease 2019 (COVID-19). The treatment of critically ill COVID-19 patients without rationing may improve the outcome. We therefore analyzed resources allocated to critically ill COVID-19 patients and their outcomes. Methods: Retrospectively, we enrolled SARS-CoV2 PCR positive patients with respiratory failure from 03/08/2020 to 04/08/2020 and followed until 05/28/2020 in the university hospital of Freiburg, Germany. Results: Thirty-four COVID-19 patients were admitted to the ICU in the defined interval with medium age of 67±13 (31-86) years. 6/34 (17.6%) were female. All patients suffered from moderate or severe acute respiratory distress syndrome (ARDS), 91.2% of the patients were intubated and 23.5% required extracorporeal membrane oxygenation (ECMO). Proning was performed in 67.6%, renal replacement therapy (RRT) was required in 35.3%. 96% required more than 20 nursing hours per day. Mean ICU stay was 21±19 (1-81) days. 60-day survival of critically ill COVID-19 patients was 50.0% (17/34). Causes of death were multi-organ failure (52.9%), refractory ARDS (17.6%) and intracerebral hemorrhage (17.6%). Conclusions: Treatment of critically ill COVID-19 patients is protracted and resource intense. In a context without resources shortage, 50% of critically ill COVID-19 survived up to 60 days.
Identification of a m6A RNA methylation regulators-based signature for predicting the prognosis of esophageal adenocarcinoma
Authors: Zhou Yue , Li Shuyan , Zou Liqing , Guo Tiantian , Yang Xi , Zhu Zhengfei 
Published: August 2020

Abstract
BackgroundN6-methyladenosine (m6A) is an abundant modification in RNAs that affects RNA metabolism, and it is reported to be closely related to cancer occurrence and metastasis. The aim of this study was to identify novel prognostic biomarkers by using m6A RNA methylation regulators capable of improving the risk-stratification criteria of survival for esophageal adenocarcinoma patients.MethodsThe gene expression data of 16 m6A methylation regulators and its relevant clinical information were extracted from The Cancer Genome Atlas (TCGA) database. The expression pattern of these m6A methylation regulators was evaluated. Consensus clustering analysis was conducted to identify clusters of esophageal adenocarcinoma patients with different prognosis. Univariate, least absolute shrinkage and selection operator (LASSO), and multivariate Cox regression analysis were performed to construct multiple-gene risk signature. A survival analysis was carried out to determine the prognosis significance.ResultsTen m6A methylation regulators (HNRNPA2B1, HNRNPC, YTHDF1, METTL3, YTHDF2, RBM15, YTHDC1, WTAP, KIAA1429 and YTHDF3) showed significant up-regulation in tumor tissue. Consensus clustering analysis identified three clusters of esophageal adenocarcinoma patients with different overall survival. A five-gene signature, HNRNPA2B1, KIAA1429, WTAP, METTL16 and ALKBH5, was constructed to serve as a prognostic indicator for distinguish esophageal adenocarcinoma patients with different prognosis. The receiver operator characteristic (ROC) curve which indicated the area under the curve (AUC) were 0.803, demonstrated that the prognostic signature had preferable prediction efficiency.Conclusionsm6A methylation regulators exert as potential biomarkers for prognostic stratification of esophageal adenocarcinoma patients and might help clinicians make individualized therapy for this patient population.
Effect of Post-Stroke Motor Training on EEG Movement-Related Cortical Potentials
Authors: Butt Maryam , Naghdy Golshah , Naghdy Fazel , Murray Geoffrey , Du Haiping 
Published: August 2020

Abstract
BackgroundRehabilitation of post-stroke patients with motor impairments promotes re-learning of lost motor functions through the brain neuroplasticity. Monitoring of electroencephalogram (EEG) signals has the potential to show neuroplasticity changes that take place during motor training.MethodsIn this study, an EEG-derived time-domain pattern namely movement-related cortical potential (MRCP) was deployed to assess the effect of motor training in seven post-stroke patients. Patients were divided into two groups; group A comprising four subjects with supratentorial lesions and group B consisting of three subjects with infratentorial lesions. Both groups participated in motor training with an AMADEO hand rehabilitation device. During pre and post-training periods, EEG signals at eight selected electrodes were recorded. In addition, hand-kinematic parameters, and clinical tests were measured at the beginning and the end of all training sessions.ResultsThe negative peak of the MRCP signals decreased at all electrodes and reached significance in seven of eight electrodes for group A after 12 training sessions, while it was decreased at all electrodes and reached significance in two of eight electrodes for group B after 24 sessions according to paired t-test (p < 0.05). Moreover, these MRCP changes correlated with improvements in kinematic parameters and clinical test results for both groups.ConclusionsThis study shows that robot-assisted training that improves clinical outcomes is associated with MRCP pattern changes. Subjects with infratentorial strokes improved slower clinically compared to subjects with supratentorial strokes. This was consistent with the longer rehabilitation required for this group of patients to produce significant changes in MRCP. The reduction of negative peaks of the MRCP signal indicates that neurological pathways are established and less cortical resources are needed for motor tasks. This study demonstrates the significance of EEG as a practical and low-cost tool in detecting patterns associated with brain neuroplasticity in the course of motor re-learning. Ethics ApprovalThe procedures performed in this study were approved by the University of Wollongong Ethics Committee (Ethics application number: 2014/400) on 03/07/2017.
Develop and validate a nomogram for predicting stroke inrheumatoidarthritis patients by electronic medical record data in northern China
Authors: Xin Fangran , Yang Bowen , Fu Lingyu , Liu Haina , Wei Tingting , Zou Cunlu , Bai Bingqing 
Published: August 2020

Abstract
Background: to develop and validate a serum lipid and inflammatory marker model based on the nomogram for the prediction of stroke risk in rheumatoid arthritis patients.Methods: This study was conducted among 313 rheumatoid arthritis with stroke patients and 1827 rheumatoid arthritis patients divided into develop and validation cohorts from the First Affiliated Hospital of China Medical University during January 2011 to December 2018. Logistic regression analysis was used to create a nomogram of predictive model of stroke risk in rheumatoid arthritis patients, after comparing with other machine algorithms. The performance of the nomogram was evaluated by discrimination, calibration and decision curve analysis, also compared with the Framingham Risk Score in predicting stroke in rheumatoid arthritis patients.Results: the nomogram was performed by logistic regression algorithm, and predictors of which included the stratifications of sex, age, systolic blood pressure, C-reactive protein, erythrocyte sedimentation rate, total cholesterol, low density lipoprotein cholesterol and the distribution of being accompanied with hy-med, diabetes, atrial fibrillation and coronary heart disease history, which exhibited a well goodness fit and a good agreement. The analysis with area under the curve, the net reclassification index, the integrated discrimination improvement and clinical use, suggested that this is an easy-to-use nomogram compared with the Framingham Risk Score.Conclusion: This study presents a risk nomogram that incorporates the traditional risk factors, serum lipids and inflammatory markers which can be used to predict stroke in rheumatoid arthritis patients.
The Physiologic Response to Rescue Therapy with Vasopressin versus Epinephrine during Experimental Pediatric Cardiac Arrest
Authors: Slovis Julia , Morgan Ryan , Landis William , Roberts Anna L , Mavroudis Constantine , Lin Yuxi , Ko Tiffany , Nadkarni Vinay , Berg Robert A , Sutton Robert , Kilbaugh Todd J 
Published: August 2020

Abstract
Background: While epinephrine is the mainstay of therapy during cardiopulmonary resuscitation, it is potentially detrimental to the cerebral vasculature and ineffective in certain populations. This study compares a rescue dose of vasopressin to a rescue dose of epinephrine after ineffective initial doses of epinephrine in diverse models of pediatric in-hospital cardiac arrest. 67 one- to three-month old female swine (10-30kg) in six experimental cohorts from one laboratory received hemodynamic-directed CPR, a resuscitation method where high quality chest compressions are provided and vasopressor administration is titrated to coronary perfusion pressure (CoPP) ³20 mmHg. Vasopressors are given when CoPP is <20 mmHg, in sequences of two doses of 0.02 mg/kg epinephrine separated by minimum one-minute, then a rescue dose of 0.4 U/kg vasopressin followed by minimum two-minutes. Invasive measurements were used to evaluate and compare the hemodynamic and neurologic effects of each vasopressor dose. Results: Increases in CoPP and cerebral blood flow (CBF) were greater with vasopressin rescue than epinephrine rescue (CoPP: +8.16 [4.35, 12.06] mmHg vs. +5.43 [1.56, 9.82] mmHg, p=0.022; CBF: +14.58 [-0.05, 38.12] vs. +0.00 [-0.77, 18.24] perfusion units (PFU), p=0.005). Twenty animals (30%) failed to achieve CoPP ³20 mmHg after two doses of epinephrine; 9/20 (45%) non-responders achieved CoPP ³20 mmHg after vasopressin. Among all animals, the increase in CBF was greater with vasopressin (+14.58 [-0.58, 38.12] vs. 0.00 [-0.77, 18.24] PFU, p=0.005).Conclusions: CoPP and CBF rose significantly more after rescue vasopressin than after rescue epinephrine. Importantly, CBF increased after vasopressin rescue, but not after epinephrine rescue. In the 30% that failed to meet CoPP of 20mmHg after two doses of epinephrine, 45% achieved target CoPP with a single rescue vasopressin dose.
Clinical and Economic Impact of Antimicrobial Stewardship Interventions Reported Among Hospital Inpatients in The Middle East: a Systematic Review Protocol
Authors: Thomas Binny , Abdulrouf Pallivalappila , Elkassem Wessam , Hail Fatema Al , Nazar Zachariah , Nasr Ziad , Singh Rajvir , Soub Hussam Al , Stewart Derek , Hail Moza Al 
Published: August 2020

Abstract
Antimicrobial Resistance (AMR) is a major global concern, negatively impacting public health outcomes (1-5), patient safety (3,6-8) and poses enormous burden on economic development and security (8-16). Internationally, data suggests, at any given time, approximately one-third of the hospitalized patients and over two-thirds of critically ill patients are prescribed antimicrobials and more than half of these prescribed antimicrobials are deemed inappropriate (5,17,18).
Non-Steroidal Anti-Inflammatory Drugs and Bone Healing in Animal Models – A Systematic Review and Meta-analysis
Authors: Al-Waeli Haider , Reboucas Ana Paula , Mansour Alaa , Morris Martin , Tamimi Faleh , Nicolau Belinda 
Published: August 2020

Abstract
Background: Non-steroidal anti-inflammatory drugs (NSAID) have excellent anti-inflammatory and analgesic properties and are extensively used to treat post-traumatic or surgical musculoskeletal pain. Although an extensive literature exists on the administration of NSAID on animal bone healing, no systematic review and meta-analysis have yet been conducted to on the subject. Such work is important as it can identify the key histomorphometric and biomechanics characteristics during the process of fracture healing and provide comparative information regarding different factors that may affect this process after NSAID administration.Methods: We performed a systematic review and meta-analysis of animal studies to estimate the effect of NSAID administration after bone fracture on healing outcomes. We searched eight databases without limiting the search to starting date up to August 1, 2017 for articles on fractured bone healing in animal models in which NSAID were administered.Results: Out of 5,818 articles screened, 45 were included and three common bone healing outcomes were analysed: biomechanical properties (maximum force to break, stiffness, and work-to-failure), micro-computed tomography (µ-CT), and histomorphometric measurements. The studies were generally of low-quality scores because crucial information, especially concerningrandomization, blinding, and allocation concealment, was poorly reported. Our results show that the negative effects of NSAID after bone fracture on certain biomechanical properties of the healing bones was not statistically significant in mice compared with other animals, in females compared with males, and in younger compared with older animals.Conclusion: The findings suggest that NSAID should be administered with caution in patients with bone fractures or in those who undergo certain orthopedic surgical procedures until prospective human clinical studies can be conducted.Systematic review registration: the protocol published and registered in SYstematic Review Center for Laboratory animal Experimentation (SYRCLE) in 2017, https://www.radboudumc.nl/getmedia/757ec408-7a9e-4635-8233-ae951effea54/Non-Steroidal-Anti-inflammatory-Drugs-and-bone-healing-in-animal-Models-Systematic-Review-and-Meta-Analysis.aspx