bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Influencing Postgraduate Career Decisions of Ophthalmology Residents
Authors: Chen Xinyi , Zafar Sidra , Srikumaran Divya , Boland Michael V. , Johnson Thomas V. , Green Laura K. , Ramanathan Saras , Pettey Jeff , Gedde Steven J. , Woreta Fasika A. 
Published: September 2020

Abstract
Objective This study aims to identify factors that influence ophthalmology residents' decision to pursue fellowship training or to practice comprehensive ophthalmology after residency.
Design This is a cross-sectional study.
Methods An anonymous survey was sent to ophthalmology residents in the United States from the graduating class of 2018. The main outcome measure was the decision to seek fellowship training or to practice comprehensive ophthalmology. Information on demographics, residency program characteristics, and factors influencing career choices were collected.
Results The overall response rate was 24.0% (112/467). Among the 112 respondents, 88 (78.6%) matched into subspecialty training. Compared with residents entering comprehensive ophthalmology, there was a greater proportion of Asians (37.5 vs. 8.3%) and a smaller proportion of non-Hispanic whites (47.7 vs. 70.8%, p = 0.029) among residents pursuing fellowship training. Residents pursuing fellowships had fewer children (0.4 vs. 0.8, p = 0.049), had less debt (median debt ≤ $100,000 vs. > $200,000, p = 0.008), had more first-author publications (4.3 vs. 1.2, p< 0.001), decided on their postgraduate career path earlier (median time postgraduate second year [PGY2] versus postgraduate third year [PGY3], p = 0.016), and were more likely to plan to practice in an academic setting (51.1 vs. 29.2%, p< 0.001) and in an urban location (44.3 vs. 12.5%, p = 0.004). In a multiple logistic regression model, factors predictive of fellowship training included a desire to acquire special skills (odds ratio [OR] =4.39; 95% confidence intervals [CI]: 1.70–16.37) and work with new technology (OR = 2.92; 95% CI: 1.16–10.02). Factors that predicted a career in comprehensive ophthalmology were higher levels of educational debt (OR = 0.35; 95% CI: 0.12–0.77), a later timing of postgraduate decision (OR = 0.17; 95% CI: 0.02–0.65), and lifestyle considerations (OR = 0.13; 95% CI: 0.03–0.36). Gender, prestige, or perceived favorable job market was not significant factors.
Conclusion The majority of U.S. ophthalmology residents matched into fellowships. A desire to gain special skills and a desire to work with new technology were major factors influencing residents to seek fellowship training. Lifestyle considerations and educational debt were more important in the decision to choose a comprehensive ophthalmology career. Future research that includes more trainees and programs may minimize the selection bias issues present in this study.
Mannose-Binding Lectin is Associated with Thrombosis and Coagulopathy in Critically Ill COVID-19 Patients
Authors: Hultström Michael , Frithiof Robert , Eriksson Oskar , Persson Barbro , Lipcsey Miklos , Ekdahl Kristina Nilsson , Nilsson Bo 
Published: September 2020

AbstractThe ongoing COVID-19 pandemic has caused significant morbidity and mortality worldwide, as well as profound effects on society. COVID-19 patients have an increased risk of thromboembolic (TE) complications, which develop despite pharmacological thromboprophylaxis. The mechanism behind COVID-19-associated coagulopathy remains unclear. Mannose-binding lectin (MBL), a pattern recognition molecule that initiates the lectin pathway of complement activation, has been suggested as a potential amplifier of blood coagulation during thromboinflammation. Here we describe data from a cohort of critically ill COVID-19 patients (n = 65) treated at a tertiary hospital center intensive care unit (ICU). A subset of patients had strongly elevated MBL plasma levels, and activity upon ICU admission, and patients who developed symptomatic TE (14%) had significantly higher MBL levels than patients without TE. MBL was strongly correlated to plasma D-dimer levels, a marker of COVID-19 coagulopathy, but showed no relationship to degree of inflammation or other organ dysfunction. In conclusion, we have identified complement activation through the MBL pathway as a novel amplification mechanism that contributes to pathological thrombosis in critically ill COVID-19 patients. Pharmacological targeting of the MBL pathway could be a novel treatment option for thrombosis in COVID-19. Laboratory testing of MBL levels could be of value for identifying COVID-19 patients at risk for TE events.
Individualized Homeopathic Medicines in Chronic Rhinosinusitis: Randomized, Double-Blind, Placebo-Controlled Trial
Authors: Misra Pankhuri , Nayak Chintamani , Chattopadhyay Abhijit , Palit Tarun Kumar , Gupta Bharti , Sadhukhan Satarupa , Bhar Koushik , Rai Shruti , Parewa Maneet , Ali Sk. Swaif , Basu Anamika , Nath Arunava , Koley Munmun , Saha Subhranil 
Published: September 2020

AbstractBackground Chronic rhinosinusitis (CRS) is a common disorder, with up to an estimated 134 million Indian sufferers, and having significant impact on quality of life (QOL) and health costs. Despite the evidence favoring homeopathy in CRS being inadequate, it is highly popular. This trial attempts to study the efficacy of individualized homeopathy (IH) medicines in comparison with placebo in patients with CRS.Methods A double-blind, randomized (1:1), placebo-controlled, preliminary trial (n = 62) was conducted at the National Institute of Homoeopathy, West Bengal, India. Primary outcome measure was the sino-nasal outcome test-20 (SNOT-20) questionnaire; secondary outcomes were the EQ-5D-5L questionnaire and EQ-5D-5L visual analog scale scores, and five numeric rating scales (0–10) assessing intensity of sneezing, rhinorrhea, post-nasal drip, facial pain/pressure, and disturbance in sense of smell, all measured at baseline and after the 2nd and 4th months of intervention. Group differences and effect sizes (Cohen's d) were calculated on the intention-to-treat sample.Results Groups were comparable at baseline. Attrition rate was 6.5% (IH: 1, Placebo: 3). Although improvements in both primary and secondary outcome measures were higher in the IH group than placebo, with small to medium effect sizes, the group differences were statistically non-significant (all p > 0.05, unpaired t-tests). Calcarea carbonica, Lycopodium clavatum, Sulphur, Natrum muriaticum and Pulsatilla nigricans were the most frequently prescribed medicines. No harmful or unintended effects, homeopathic aggravations or any serious adverse events were reported from either group.Conclusion There was a small but non-significant direction of effect favoring homeopathy, which ultimately renders the trial as inconclusive. Rigorous trials and independent replications are recommended to arrive at a confirmatory conclusion. [Trial registration: CTRI/2018/03/012557; UTN: U1111–1210–7201].
Enterochromaffin Cells and Mast Cells in Acute Appendicitis
Authors: Mohan Bhavya P. , Aravindan K.P. 
Published: September 2020

Abstract
Background and Objective Serotonin levels are increased in acute appendicitis. We investigated the possible source of this increase. The aim of this study was to compare the distribution and density of epithelial and nonepithelial enterochromaffin (EC) cells as well as numbers of degranulated and nondegranulated mast cells in different layers of normal appendices and acute appendicitis.
Methods Sections from 15 cases of acute appendicitis and 10 cases where the appendix was morphologically normal were stained with Hematoxylin & Eosin, Toluidine blue, and immunohistochemically for chromogranin and CD-117. EC cells stained by chromogranin were counted per crypt and extraepithelial EC cells counted and expressed as cells per unit area (mm2). Mast cells stained by Toluidine blue and CD-117 were counted in lamina propria, submucosa, and muscle layers. The difference between Toluidine blue and CD117 stained mast cells was taken to be an estimate of degranulated cells. The cell counts were expressed per unit area (mm2) as well as per cross-sectional area of the appendix.
Results There was no statistically significant difference in epithelial and extraepithelial EC cells between acute appendicitis and normal appendix. Estimated mast cell degranulation as indicated by mast cell counts per cross-sectional area is greatly increased in acute appendicitis when compared with normal.
Conclusion Degranulated mast cells rather than EC cells may be the main source of raised serotonin in acute appendicitis.
Physical chemistry and technological applications of gas hydrates: topical aspects
Authors: Manakov Andrey Yu. , Stoporev Andrey S. 
Published: September 2020

The review considers the research and engineering works in selected fields of the physical chemistry of gas hydrates and gas hydrate technologies, mainly performed over the last 10–15 years. Data on the hydrate structures are given, including the structures formed during phase transitions at low temperatures, and on new hydrate structures that are formed under ultrahigh pressures. The dynamics of guest and host subsystems is considered in brief. Phase diagrams of systems involving hydrate formation (in particular, in some porous media) and methods for calculating phase equilibria and compositions of hydrates in these systems are analyzed. Data on the hydrates formed by ‘non-classical’ hydrate formers (alcohols, amines, ammonia,etc.) studied in the last decade and on some of their properties are presented. The Section devoted to hydrate formation kinetics addresses the effect of compounds dissolved in water (surfactants, low-dosage inhibitors) and catalysts on this process. The hydrate growth dynamics on the water surface and hydrate decomposition-formation processes in disperse systems are discussed. Among technological applications, the attention is focused on gas storage and transportation in the hydrate form. Methods for the preparation of hydrates are considered.The bibliography includes 618 references.
Analysis of the differential expression profile of miRNAs in myocardial tissues of rats with burn injury
Authors: Guo Jingdong , Zhu Zhensen , Zhang Dongmei , Chen Bo , Zou Ben , Gao Songying , Zhu Xiongxiang 
Published: September 2020

Abstract
Fifteen percent third-degree burn rat model was used to identify miRNAs that are markers of burn injury-induced myocardial damage. Cardiac tissues were evaluated to determine miRNA profile sequencing. Pearson’s correlation analysis was used between miRNAs and injury markers. ROC curve analysis was used to estimate miRNA’s sensitivity and specificity for the diagnosis of myocardial damage caused by burn injury. The sequencing analysis revealed 23 differentially expressed miRNAs. Pearson’s correlation analysis revealed that rno-miR-190b-3p and C5b9, rno-miR-341, rno-miR-344b-3p and TnI, rno-miR-344b-3p and CK-MB were significantly positively correlated, respectively. ROC curve analysis demonstrated that rno-miR-341, rno-miR-344b-3p, and rno-miR-190b-3p exhibited high sensitivity and specificity for the diagnosis of myocardial damage caused by burn injury. In conclusion, our results suggest that rno-miR-341, rno-miR-344b-3p, and rno-miR-190b-3p have the potential to be used as sensitive and specific biomarkers to diagnose myocardial damage caused by burn injury.
Are KIF6 and APOE polymorphisms associated with power and endurance athletes?
Authors: Wojciechowicz Bartosz , Laguette M.‐J. Nancy , Sawczuk Marek , Humińska‐Lisowska Kinga , Maciejewska‐Skrendo Agnieszka , Ficek Krzysztof , Michałowska‐Sawczyn Monika , Leońska‐Duniec Agata , Kaczmarczyk Mariusz , Chycki Jakub , Trybek Grzegorz , September Alison V. , Cięszczyk Paweł 
Published: September 2020

AbstractGenetic polymorphisms within physiologically relevant KIF6 and APOE genes were examined in the context of athletic performance. KIF6 and ApoE are involved in cardiovascular health, modulation of lipid level and neurotransmission amongst others. The aim of this study was to examine whether three polymorphisms, KIF6 rs20455T > C, APOE rs429358T > C and APOE rs7412 C > T, were associated with athletic status of an athlete defined as performance type (endurance or power). Genotyping was performed using real‐time PCR on buccal genomic DNA from 204 Polish athletes including 104 endurance and 100 power athletes, and 161 sedentary individuals. APOE rs429358 genotype frequencies differed significantly between power athletes and sedentary individuals (p = 0.046). KIF6 rs20455 and APOE rs7412 were found to be epistatically associated with the power athletic status (p = 0.032). KIF6 rs20455, APOE rs429358 and APOE rs7412 were associated with athletic status of Polish athletes. In the future, these polymorphisms could contribute to predictive models aimed at assessment of an individual's athletic status.
Micro-cathode arc thruster using segmented insulated anode with a slit for micro-satellite propulsion
Authors: Tian Jia , Liu Wenzheng , Zhang Wenjun , Gao Yongjie , Zhao Luxiang 
Published: September 2020

Abstract
Micro-cathode arc thruster (µCAT) is an electric propulsion device that uses metal cathode material as propellent to create plasma and ultimately produce thrust, which is suitable to serve as a propulsion system for microsatellites. In order to improve propulsion performance of the µCAT, a structure using a segmented insulated anode with a slit (SISA-µCAT), which mainly consists of a truncated-cone-shaped cathode, an insulating sleeve, a segmented anode including proximal anode and distant anode, and an anodic insulation layer with a slit, is proposed in this paper. We compare and analyze the differences in discharge characteristics, plasma generation characteristics and propulsion performance among the SISA-µCAT, a segmented exposed anode µCAT (SEA-µCAT) and the known non-segmented exposed anode µCAT (NSEA-µCAT). Study results show that when adopting the SISA-µCAT, plasma ejection performance is effectively improved by utilizing the special spatial electric field formed between segmented anode and the slit structure on the anodic insulation layer, thus improving the propulsion performance of the µCAT. During a single shot, compared with the NSEA-µCAT, peak values of generated thrust and thrust-to-power ratio are increased by 11.4 times and 10.4 times, respectively, by using the SISA-µCAT. Plasma parameters indicate that peak plasma density and propagation speed are increased by 8.2 times and 2.93 times, respectively.
Neutron drip line of Z= 9–11 isotopic chains *
Authors: An Rong , Shen Guo-Fang , Zhang Shi-Sheng , Geng Li-Sheng 
Published: September 2020

Abstract
A recent experimental breakthrough identified the last bound neutron-rich nuclei in fluorine and neon isotopes. Based on this finding, we perform a theoretical study of Z = 9, 10, 11, 12 isotopes in the relativistic mean field (RMF) model. The mean field parameters are assumed from the PK1 parameterization, and the pairing correlation is described by the particle number conservation BCS (FBCS) method recently formulated in the RMF model. We show that the FBCS approach plays an essential role in reproducing experimental results of fluorine and neon isotopes. Furthermore, we predict 39Na and 40Mg to be the last bound neutron-rich nuclei in sodium and magnesium isotopes.
Fully implanted adaptive deep brain stimulation in freely moving essential tremor patients
Authors: Ferleger B I , Houston B , Thompson M C , Cooper S S , Sonnet K S , Ko A L , Herron J A , Chizeck H J 
Published: September 2020

AbstractObjective. Deep brain stimulation (DBS) is a safe and established treatment for essential tremor (ET) and several other movement disorders. One approach to improving DBS therapy is adaptive DBS (aDBS), in which stimulation parameters are modulated in real time based on biofeedback from either external or implanted sensors. Previously tested systems have fallen short of translational applicability due to the requirement for patients to continuously wear the necessary sensors or processing devices, as well as privacy and security concerns.Approach. We designed and implemented a translation-ready training data collection system for fully implanted aDBS. Two patients chronically implanted with electrocorticography strips over the hand portion of M1 and DBS probes in the ipsilateral ventral intermediate nucleus of the thalamus for treatment of ET were recruited for this study. Training was conducted using a translation-ready distributed training procedure, allowing a substantially higher degree of control over data collection than previous works. A linear classifier was trained using this system, biased towards activating stimulation in accordance with clinical considerations.Main results. The clinically relevant average false negative rate, defined as fraction of time during which stimulation dropped below12clinical levels during movement epochs, was 0.036. Tremor suppression, calculated through analysis of gyroscope data, was 33.2% more effective on average with aDBS than with continuous DBS. During a period of free movement with aDBS, one patient reported a slight paresthesia; patients noticed no difference in treatment efficacy between systems.Significance. Here is presented the first translation-ready training procedure for a fully embedded aDBS control system for MDs and one of the first examples of such a system in ET, adding to the consensus that fully implanted aDBS systems are sufficiently mature for broader deployment in treatment of movement disorders.
Side-impact collision: mechanics of obstacle negotiation in sidewinding snakes
Authors: Astley Henry C , Rieser Jennifer M , Kaba Abdul , Paez Veronica M , Tomkinson Ian , Mendelson Joseph R , Goldman Daniel I 
Published: September 2020

Abstract
Snakes excel at moving through cluttered environments, and heterogeneities can be used as propulsive contacts for snakes performing lateral undulation. However, sidewinding, which is often associated with sandy deserts, cuts a broad path through its environment that may increase its vulnerability to obstacles. Our prior work demonstrated that sidewinding can be represented as a pair of orthogonal body waves (vertical and horizontal) that can be independently modulated to achieve high maneuverability and incline ascent, suggesting that sidewinders may also use template modulations to negotiate obstacles. To test this hypothesis, we recorded overhead video of four sidewinder rattlesnakes (Crotalus cerastes) crossing a line of vertical pegs placed in the substrate. Snakes used three methods to traverse the obstacles: a Propagate Through behavior in which the lifted moving portion of the snake was deformed around the peg and dragged through as the snake continued sidewinding (115/160 runs), Reversal turns that reorient the snake entirely (35/160), or switching to Concertina locomotion (10/160). The Propagate Through response was only used if the anterior-most region of static contact would propagate along a path anterior to the peg, or if a new region of static contact could be formed near the head to satisfy this condition; otherwise, snakes could only use Reversal turns or switch to Concertina locomotion. Reversal turns allowed the snake to re-orient and either escape without further peg contact or re-orient into a posture amenable to using the Propagate Through response. We developed an algorithm to reproduce the Propagate Through behavior in a robophysical model using a modulation of the two-wave template. This range of behavioral strategies provides sidewinders with a versatile range of options for effectively negotiating obstacles in their natural habitat, as well as provide insights into the design and control of robotic systems dealing with heterogeneous habitats.
Disturbance reinforces community assembly processes differentially across spatial scales
Authors: Escobedo Víctor M , Rios Rodrigo S , Alcayaga-Olivares Yulinka , Gianoli Ernesto 
Published: September 2020

AbstractBackground and AimsThere is a paucity of empirical research and a lack of predictive models concerning the interplay between spatial scale and disturbance as they affect the structure and assembly of plant communities. We proposed and tested a trait dispersion-based conceptual model hypothesizing that disturbance reinforces assembly processes differentially across spatial scales. Disturbance would reinforce functional divergence at the small scale (neighbourhood), would not affect functional dispersion at the intermediate scale (patch) and would reinforce functional convergence at the large scale (site). We also evaluated functional and species richness of native and exotic plants to infer underlying processes. Native and exotic species richness were expected to increase and decrease with disturbance, respectively, at the neighbourhood scale, and to show similar associations with disturbance at the patch (concave) and site (negative) scales.MethodsIn an arid shrubland, we estimated species richness and functional dispersion and richness within 1 m2 quadrats (neighbourhood) nested within 100 m2 plots (patch) along a small-scale natural disturbance gradient caused by an endemic fossorial rodent. Data for the site scale (2500 m2 plots) were taken from a previous study. We also tested the conceptual model through a quantitative literature review and a meta-analysis.Key ResultsAs spatial scale increased, disturbance sequentially promoted functional divergence, random trait dispersion and functional convergence. Functional richness was unaffected by disturbance across spatial scales. Disturbance favoured natives over exotics at the neighbourhood scale, while both decreased under high disturbance at the patch and site scales.ConclusionsThe results supported the hypothesis that disturbance reinforces assembly processes differentially across scales and hampers plant invasion. The quantitative literature review and the meta-analysis supported most of the model predictions.
MR-Clust: clustering of genetic variants in Mendelian randomization with similar causal estimates
Authors: Foley Christopher N , Mason Amy M , Kirk Paul D W , Burgess Stephen 
Published: September 2020

Abstract

Motivation
Mendelian randomization is an epidemiological technique that uses genetic variants as instrumental variables to estimate the causal effect of a risk factor on an outcome. We consider a scenario in which causal estimates based on each variant in turn differ more strongly than expected by chance alone, but the variants can be divided into distinct clusters, such that all variants in the cluster have similar causal estimates. This scenario is likely to occur when there are several distinct causal mechanisms by which a risk factor influences an outcome with different magnitudes of causal effect. We have developed an algorithm MR-Clust that finds such clusters of variants, and so can identify variants that reflect distinct causal mechanisms. Two features of our clustering algorithm are that it accounts for differential uncertainty in the causal estimates, and it includes ‘null’ and ‘junk’ clusters, to provide protection against the detection of spurious clusters.

Results
Our algorithm correctly detected the number of clusters in a simulation analysis, outperforming methods that either do not account for uncertainty or do not include null and junk clusters. In an applied example considering the effect of blood pressure on coronary artery disease risk, the method detected four clusters of genetic variants. A post hoc hypothesis-generating search suggested that variants in the cluster with a negative effect of blood pressure on coronary artery disease risk were more strongly related to trunk fat percentage and other adiposity measures than variants not in this cluster.

Availability and implementation
MR-Clust can be downloaded from https://github.com/cnfoley/mrclust.

Supplementary information
Supplementary data are available at Bioinformatics online.