bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of remote ischaemic conditioning on platelet reactivity and endogenous fibrinolysis in ST-elevation myocardial infarction: a substudy of the CONDI-2/ERIC-PPCI randomized controlled trial
Authors: Gorog Diana A , Farag Mohamed , Spinthakis Nikolaos , Yellon Derek M , Bøtker Hans Erik , Kharbanda Rajesh K , Hausenloy Derek J 
Published: March 2020

Abstract

Aims
Remote ischaemic conditioning (RIC) has been shown to reduce myocardial infarct size in animal models of myocardial infarction. Platelet thrombus formation is a critical determinant of outcome in ST-segment elevation myocardial infarction (STEMI). Whether the beneficial effects of RIC are related to thrombotic parameters is unclear.

Methods and results
In a substudy of the Effect of Remote Ischaemic Conditioning on clinical outcomes in STEMI patients undergoing Primary Percutaneous Coronary Intervention (ERIC-PPCI) trial, we assessed the effect of RIC on thrombotic status. Patients presenting with STEMI were randomized to immediate RIC consisting of an automated autoRIC™ cuff on the upper arm inflated to 200 mmHg for 5 min and deflated for 5 min for four cycles (n = 53) or sham (n = 47). Venous blood was tested at presentation, discharge (48 h) and 6–8 weeks, to assess platelet reactivity, coagulation, and endogenous fibrinolysis using the Global Thrombosis Test and thromboelastography. Baseline thrombotic status was similar in the two groups. At discharge, there was some evidence that the time to in vitro thrombotic occlusion under high shear stress was longer with RIC compared to sham (454 ± 105 s vs. 403 ± 105 s; mean difference 50.1 s; 95% confidence interval 93.7–6.4, P = 0.025), but this was no longer apparent at 6–8 weeks. There was no difference in clot formation or endogenous fibrinolysis between the study arms at any time point.

Conclusion
RIC may reduce platelet reactivity in the first 48 h post-STEMI. Further research is needed to delineate mechanisms through which RIC may reduce platelet reactivity, and whether it may improve outcomes in patients with persistent high on-treatment platelet reactivity.
Phylogenetic evaluation of the true-branched heterocytous cyanobacteria and description of soil dwelling Westiellopsis akinetica sp. nov.
Authors: Mishra Deeksha , Suradkar Archana , Saraf Aniket , Singh Prashant 
Published: March 2020

ABSTRACT
Soil inhabiting true branching heterocytous cyanobacterium strain SNS 3 with T-type branching was collected from the campus of Banaras Hindu University, India and characterized using the polyphasic approach. Morphological observations showed the presence of akinetes (in chain), hormogonia and monocytes. Physiological characterization of strain SNS 3 showed high content of carotenoid in comparison to chlorophyll a content along with also exhibiting a higher C/N ratio in the nitrogen deficient BG110 medium. 16S rRNA gene sequencing and subsequent phylogeny indicated strong clustering of the strain SNS 3 within the Westiellopsis clade. Folded secondary structures of the ITS region showed visible differences in the D1-D1’ and BoxB helix of the strain SNS 3. The polyphasic approach indicated the strain SNS 3 as a new member of the genus Westiellopsis with the name proposed being Westiellopsis akinetica sp. nov. on the basis of the International Code of Nomenclature for Algae, Fungi and Plants. Intense phylogenetic evaluation of the entire true-branched heterocytous clade indicated the need for more revisionary attempts for demarcating the sensu stricto clades along with highlighting the scope for further taxonomic revisions in the future.
Star formation in low-redshift cluster dwarf galaxies
Authors: Rude Cody M , Sultanova Madina R , Kaduwa Gamage Gihan L Ipita , Barkhouse Wayne A , Kalawila Vithanage Sandanuwan P 
Published: March 2020

ABSTRACT
Evolution of galaxies in dense environments can be affected by close encounters with neighbouring galaxies and interactions with the intracluster medium. Dwarf galaxies (dGs) are important as their low mass makes them more susceptible to these effects than giant systems. Combined luminosity functions (LFs) in the r and u band of 15 galaxy clusters were constructed using archival data from the Canada–France–Hawaii Telescope. LFs were measured as a function of clustercentric radius from stacked cluster data. Marginal evidence was found for an increase in the faint-end slope of the u-band LF relative to the r-band with increasing clustercentric radius. The dwarf-to-giant ratio (DGR) was found to increase toward the cluster outskirts, with the u-band DGR increasing faster with clustercentric radius compared to the r-band. The dG blue fraction was found to be ∼2 times larger than the giant galaxy blue fraction over all clustercentric distance (∼5σ level). The central concentration (C) was used as a proxy to distinguish nucleated versus non-nucleated dGs. The ratio of high-C to low-C dGs was found to be ∼2 times greater in the inner cluster region compared to the outskirts (2.8σ level). The faint-end slope of the r-band LF for the cluster outskirts (0.6 ≤ r/r200 &lt; 1.0) is steeper than the Sloan Digital Sky Survey field LF, while the u-band LF is marginally steeper at the 2.5σ level. Decrease in the faint-end slope of the r- and u-band cluster LFs towards the cluster centre is consistent with quenching of star formation via ram pressure stripping and galaxy–galaxy interactions.
A Place at the Table: Organization Theory and Public Management
Authors: Whitford Andrew B , Milward H Brinton , Galaskiewicz Joseph , Khademian Anne M 
Published: March 2020

Abstract
In November 2018, the University of Arizona’s School of Government and Public Policy hosted an international workshop on the role of organization theory in public management. The intention was to renew interest in organization theory in public management research. Scholars such as Herbert Simon, Herbert Kaufman, and Richard Selznick made seminal contributions to organization theory through the study of public organizations from the 1940s through the 1960s. In our estimation, organization theory is underrepresented in public administration scholarship for the last several decades. There are natural reasons for this trend, including the discipline’s turn towards organizational behavior and the ascendancy of techniques that advance the study of large datasets and those that allow for experimental control. The recent emergence of “behavioral public administration” is a prominent example of this evolution. This symposium is an attempt to make a place at the table of public management for organization theory. The articles in this symposium contain articles from scholars who operate in the tradition of classic organization theory in new and innovative ways to lend intellectual purchase to studies of public organizations and public organizational networks.
A workshop report on the causes and consequences of sleep health disparities
Authors: Jackson Chandra L , Walker Jenelle R , Brown Marishka K , Das Rina , Jones Nancy L 
Published: March 2020

Abstract
Sleep deficiencies, which include insufficient or long sleep duration, poor sleep quality, and irregular timing of sleep, are disproportionately distributed among populations that experience health disparities in the United States. Sleep deficiencies are associated with a wide range of suboptimal health outcomes, high-risk health behaviors, and poorer overall functioning and well-being. This report focuses on sleep health disparities (SHDs), which is a term defined as differences in one or more dimensions of sleep health on a consistent basis that adversely affect designated disadvantaged populations. SHDs appear to share many of the same determinants and causal pathways observed for health outcomes with well-known disparities. There also appears to be common behavioral and biological mechanisms that connect sleep with poorer health outcomes, suggesting a link between SHDs and other health disparities observed within these designated populations. In 2018, the National Institute on Minority Health and Health Disparities, the National Heart, Lung, and Blood Institute, and the Office of Behavioral and Social Sciences Research convened a workshop with experts in sleep, circadian rhythms, and health disparities to identify research gaps, challenges, and opportunities to better understand and advance research to address SHDs. The major strategy to address SHDs is to promote integration between health disparity causal pathways and sleep and circadian-related mechanisms in research approaches and study designs. Additional strategies include developing a comprehensive, integrative conceptual model, building transdisciplinary training and research infrastructure, and designing as well as testing multilevel, multifactorial interventions to address SHDs.
Investigation of the association between entrepreneurship life cycle, ownership structure and market timing theory
Authors: Mabrouk Lamia , Boubaker Adel 
Published: March 2020

PurposeThe purpose of this study is to explore at what stage of a company’s life cycle the theory of market timing has explained debt. Drawing on a unified conceptual framework of market timing theory, the authors scrutinize the impact of life cycle and ownership structure on the market condition.Design/methodology/approachBased on a sample of 24 Tunisian companies listed on the stock exchange and 100 French firms listed on the CAC All-Tradable on a 10-year period, this paper grounded the market timing theory and attempted to clear the relation between ownership structure, life cycle of the firm and market timing theory by statistical analysis.FindingsThe findings of panel data modeling indicate that when the life cycle was used as an explanatory variable, it was found that the variable reflecting the market timing is not significant in either context; it means that no significant support is found in the theory of market timing in both countries. Whereas when the life cycle was used as a dummy variable, it was found that the life cycle has an impact on debt only in the Tunisian context.Practical implicationsThis study has several important implications for researchers and practitioners. The findings reported here clarify the strength of the impact of life cycle on the market timing, when it explains the debt in the two contexts and the impact of ownership structure such as the managerial ownership and concentration of capital on debt.Originality/valueThis study contributes to examine the theory of debt in different phases of life cycle. Focused on the case of Tunisian and French firms, this study is unique and valuable.
The impact of organizational structure and work autonomy in fostering entrepreneurial tendencies and job performance
Authors: Ahmetoglu Gorkan , Scarlett Lauren , Codreanu Sonia-Cristina , Chamorro-Premuzic Tomas 
Published: March 2020

Purpose
Research examining the influence of organizational factors on entrepreneurial tendencies and performance within organizations is scarce. The purpose of this paper is to investigate the effect of organizational structure and work autonomy on entrepreneurial tendencies, locus of control and performance.

Design/methodology/approach
Data were obtained online using validated self-report questionnaires in a sample of 181 currently employed individuals.

Findings
The results showed organizational structure components to be related to work autonomy and performance, but not to individual-level variables. However, work autonomy related to entrepreneurial tendencies and locus of control, indicating potential indirect effects of organizational structure on individual-level variables via work autonomy. Entrepreneurial tendencies and locus of control were positively related to performance.

Originality/value
Whilst the mediating effect of a number of individual-level traits has been examined in the past, very little research has looked at how organizational factors may influence entrepreneurial tendencies. Fostering entrepreneurial tendencies in employees may facilitate corporate entrepreneurship and performance within organizations.
The perception of entrepreneurship culture by internal university stakeholders
Authors: Kusio Tomasz , Fiore Mariantonietta 
Published: March 2020

Purpose
As nowadays the knowledge economy puts a strong emphasis on the universities’ role in the present economy, the recent challenge focuses on the interrelations between entrepreneurship culture and academic engagement. This study aims to investigate the new role that universities are assuming as entrepreneurial entities and gather information taking place internal university stakeholders and students’ perception on entrepreneurship education. The research hypothesis stands entrepreneurship is mainly supposed as being professionally and educationally active rather than setting up a company.

Design/methodology/approach
The present study carries out a study on the perception of entrepreneurship education conducted among students of the University of Economics in Krakow in the winter semester of the academic year 2017/2018. The selected target group meets the criteria of the different national country origin of the respondents. Another criterion for selecting the target group was diversity in the field of students’ academic interests.

Findings
The results of the study give a clear view of the still valid confirmation of the growing academic role in terms of entrepreneurship culture development that appears necessary to address the demand for global competitiveness. In particular, it is possible to categorize two groups of people, moderate and strong supporters of recognition that entrepreneurship is not only about starting a company but also at the same time that it is an expression of its own dynamic and entrepreneurial attitudes.

Practical implications
As the importance of entrepreneurship in the context of an entrepreneurial university is rising and the definition of entrepreneurship goes beyond its understanding of starting a business, universities and academic engagement can and have to better address and focus their planning of the courses and their contents.

Originality/value
The study sheds some light and gives some interesting perspectives on the issue of different levels of entrepreneurship education expectations against different levels at which this education should be provided. In addition, it is in line with the EU entrepreneurship competence framework (EntreComp) aimed at defining tools to improve the entrepreneurial capacity and culture of EU citizens and organizations by means of consensus among stakeholders and by establishing a bond between education and study.
Giving light to mega-event planning: residents' perceptions on total eclipse weekend
Authors: Sox Carole B. , Sox Mary M. , Campbell Jeffrey M. 
Published: March 2020

PurposeMega-events have been the topic of unprecedented consideration within recent research. Research on the residents' perspectives, however, is still in the infancy stage, yet a key contributor to the overall legacy planning considerations and process. This research investigates resident perceptions toward a mega-event to assist with planning/execution of such events in addition to advancing knowledge within this area.Design/methodology/approachFor this research, an online survey was utilized to reach out to residents in the host city during the mega-event, Solar Eclipse Weekend. Factor analysis and cluster analysis were used to analyze the results.FindingsUsing exploratory factor analysis, 305 online surveys were analyzed. Using varimax rotation, factor analysis determined four significant factors: environment, local engagement, tourism support, and infrastructure. Cluster analysis was then conducted identifying three clusters of residents labeled neutralists, supporters and enthusiasts.Practical implicationsThe practical implications should be of assistance to professional event planners, city governments and destination marketing organizations. Through utilization of the information provided, community participation should be sought after throughout the planning phase and into the management and execution of large events to best gain resident support.Originality/valueThis research further explored residents' perspectives of a mega-event. While this area of research has been noted in strategic approaches to planning, managing and executing mega-events, the research on stakeholders (such as residents') perspectives is still in the infancy stage. This research contributes to advancing industry planning approaches and strategic execution, in addition to advancing academic knowledge within this area.
The Perils and Penalties of Meritocracy: Sanctioning Inequalities and Legitimating Prejudice
Authors: Reay Diane 
Published: March 2020

AbstractThis article deploys insights from Michael Young’s 1958 satire The Rise of the Meritocracy to challenge the dominant ideology of meritocracy in contemporary British society. It draws on ethnographic research in schools over a twenty‐five year period to illustrate the damage the illusion of meritocracy inflicts on children and young people, but particularly those from working class backgrounds. It argues that the consequences of the pretence of meritocracy are to be found in everyday practices of testing, hyper‐competition and setting, and beyond the classroom in the designation of predominantly working class schools as ‘rubbish schools for rubbish learners’. It concludes that, beyond the negative consequences for working class learners, there are wider consequences for British society, exacerbating social divisions and encouraging the growth of distrust, prejudice, envy, resentment, and contempt between different social groups.
Successful treatment of advanced lung adenocarcinoma complicated with Lambert‐Eaton myasthenic syndrome: A case report and literature review
Authors: Wang Aili , Zhang Xin , Yi Jiawen , Zhu Min , Zhang Yuhui 
Published: March 2020

Lambert‐Eaton myasthenic syndrome (LEMS) is a rare disease characterized by involvement of the neuromuscular junction. Most cases have an underlying malignancy, especially small‐cell lung cancer (SCLC), while adenocarcinoma is less common. Here, we report a rare case of metastatic lung adenocarcinoma complicated with LEMS. In this case, L858R mutation was detected in the 21st exon of the EGFR gene. First‐line treatment with gefitinib was given, and the patient has survived for more than six years. Early diagnosis of LEMS and timely and effective treatment can result in a good prognosis. We also searched for “lung cancer”, or “carcinoma of lung”, or “adenocarcinoma of lung”, or “Lambert‐Eaton myasthenic syndrome” in PubMed until 1 December 2019. Seven cases of lung adenocarcinoma complicated with LEMS were found, most of which had a poor prognosis.Key pointsThis article reports a rare case of metastatic lung adenocarcinoma with EGFR mutation, complicated with LEMS. Gefitinib was given as first‐line treatment, and resulted in a good prognosis.
When an iconic native animal is overabundant: The koala in southern Australia
Authors: Whisson Desley A. , Ashman Kita R. 
Published: March 2020

AbstractManagement of overabundant native species is challenging at the best of times but is even more so when it involves an iconic species that is threatened in part of its range. Here, we examine koala overabundance, a situation that arises in some locations within the species' southern range. We consider the variable conservation status of the koala throughout its range, discuss where and why overabundance occurs, and its consequences. Programs to manage koala overabundance and impacts are generally ineffective, relying on costly and slow acting fertility control and translocation, and implemented only when a crisis already has occurred. A change in management approach is needed. Decisions should be based on an evidence‐based and transparent decision‐making framework that involves predicting where overabundance is likely, where damage costs will be high, and where proactive management is likely to be effective. With more than 65% of Australia's koala population occurring in the south and declining northern populations, a more considered approach to managing southern koalas for conservation of the species is needed.
Genome‐wide association study for host genetic factors associated with equine herpesvirus type‐1 induced myeloencephalopathy
Authors: Dunuwille Wangisa M. B. , YousefiMashouf Navid , Balasuriya Udeni B. R. , Pusterla Nicola , Bailey Ernest 
Published: March 2020

AbstractBackgroundEquid herpesvirus (EHV‐1) infections in horses can lead to equine herpesvirus myeloencephalopathy (EHM), characterised by neurological clinical signs. The sporadic occurrence of the disease in horse herds suggests a host genetic component. A recent study reported an association between the occurrence of EHM and genetic markers on horse chromosome 6 (ECA6).ObjectivesTo investigate the association of EHM with genetic host factors, especially with reference to the association reported for ECA6.Study designGenome‐wide association study (GWAS) was conducted based on 94 horses that had EHV‐1 infections and comparing the 27 developing clinical EHM to the 67 which did not.MethodsDNA samples were tested from 94 horses for 382,529 single nucleotide polymorphisms (SNPs) with the Affymetrix Axiom 670K SNP array to identify possible associations with EHM. The data analysis included tests for basic, additive, dominant and recessive modes of inheritance, haplotype associations and runs of homozygosity (ROH).ResultsResults from this study did not identify significant SNPs, haplotypes or ROH associations with the development of EHM following EHV‐1 infections and excluded the involvement of a recessive genetic factor in the susceptibility to develop EHM.Main limitationsSample size and complex phenotype.ConclusionsThe results exclude the involvement of a recessive genetic factor in the susceptibility to develop clinically apparent EHM but do not have the power to exclude the involvement of other, complex host genetic factors. Furthermore, there was no association between development of EHM and genes on equine chromosome 6, as previously reported.