bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis, Assessment and Early Warning of Mudflow Disasters along the Shigatse Section of the China–Nepal Highway
Authors: Xiao Liming , Zhang Yonghong , Ge Taotao , Wang Chen , Wei Ming 
Published: March 2020

Abstract
China–Nepal Highway is an important international passage connecting China and Nepal. Owing to its location in a complex mountainous area in the Qinghai– Tibet Plateau, the Shigatse section of the China–Nepal Highway is often impacted and troubled by mudflow. In order to effectively conduct road construction and maintenance and improve early disaster-warning capability, the relationship between various hazard factors and disaster points was analysed. It is found that four factors such as slope, precipitation, soil type and digital elevation have the strongest correlation with the occurrence of the disasters. From the distribution of disaster points, it is observed that the disaster point is closely related to the slope, its local correlation with precipitation is good and the its local correlation with the soil type and Digital Elevation Model (DEM) data is significant. In order to quantitatively evaluate the susceptibility of mudflow disasters in the Shigatse region, this paper uses the analytic hierarchy process (AHP) as the main analysis method supplemented by the fuzzy clustering method. The results show that the slope, when accompanied by heavy rainfall, is the most important factor among four factors. In this paper, the neural network method is used to establish the identification and early warning model of mudflow susceptibility. When the recognition rate reaches 66% or above, it can be used as an early-warning threshold for mudflow disasters. This study has conducted a useful exploration of the research, assessment and early warning of mudflow disasters along the Shigatse section of the China–Nepal Highway.
Redefining proteostasis transcription factors in organismal stress responses, development, metabolism, and health
Authors: Jones Laura M. , Chen Yannic , van Oosten-Hawle Patricija 
Published: March 2020

AbstractEukaryotic organisms have evolved complex and robust cellular stress response pathways to ensure maintenance of proteostasis and survival during fluctuating environmental conditions. Highly conserved stress response pathways can be triggered and coordinated at the cell-autonomous and cell-nonautonomous level by proteostasis transcription factors, including HSF1, SKN-1/NRF2, HIF1, and DAF-16/FOXO that combat proteotoxic stress caused by environmental challenges. While these transcription factors are often associated with a specific stress condition, they also direct “noncanonical” transcriptional programs that serve to integrate a multitude of physiological responses required for development, metabolism, and defense responses to pathogen infections. In this review, we outline the established function of these key proteostasis transcription factors at the cell-autonomous and cell-nonautonomous level and discuss a newly emerging stress responsive transcription factor, PQM-1, within the proteostasis network. We look beyond the canonical stress response roles of proteostasis transcription factors and highlight their function in integrating different physiological stimuli to maintain cytosolic organismal proteostasis.
Radiofrequency ablation triggers the migration of hepatocellular carcinoma cells by suppressing miR-148a-5p
Authors: Wang Haicun , Cao Yang , Hu Kaiwen , Li Quanwang , Yang Yufei , Wang Lanrong , Qin Xiaoyan , Qiao Bingli , Cheng Liuqi , Li Peipei , Dui Weihua 
Published: March 2020

Abstract
Increasing evidences suggest that insufficient radiofrequency ablation (IRFA) can paradoxically promote tumor invasion and metastatic processes, whereas the effects of moderate hyperthermia on cancer progression are not well illustrated. Our study found that IRFA can increase the in vitro migration, invasion, and epithelial–mesenchymal transition (EMT) of hepatocellular carcinoma (HCC) cells via induction of Snail, a master regulator of EMT events. Among measured miRNAs, IRFA can decrease the expression of miR-148a-5p in HCC cells. Whereas overexpression of miR-148a-5p can reverse IRFA-induced migration of HCC cells and upregulation of Snail, mechanistically overexpression of miR-148a-5p can directly target and decrease the expression of protein kinase ATM (ataxia telangiectasia mutated), which can increase protein stability of Snail. Collectively, our data suggest that IRFA can regulate the miR-148a-5p/ATM/Snail axis to trigger migration of HCC cells.
Gödels ontologischer Gottesbeweis im Kontext der Systematischen Theologie
Authors: Alles Thorben 
Published: March 2020

Zusammenfassung
Kurt Gödels Ontological Proof von 1970 ist einer der bedeutendsten Beweise der Existenz Gottes unserer Zeit. Die Formulierung in formaler Logik erschwert erstens das Verständnis und scheint zweitens einen unbedingten Wahrheitsbezug zu implizieren. Seit seiner Veröffentlichung bis heute wurde sich auf vielfältige Weise mit dem Beweis auseinandergesetzt und dazu publiziert. Allerdings fehlt bislang eine theologische – insbesondere eine protestantisch-theologische – Auseinandersetzung. Dieser Aufsatz soll eine systematische Übersicht über die bisherige Forschung sowie eine Einführung und Erläuterung des Beweises geben. Der theologische Forschungsbeitrag besteht hierbei vor allem in einer Relativierung einiger mit dem Beweis und seiner Rezeption verbundenen Ansprüche.
Association between obesity and venous thromboembolism
Authors: Hotoleanu Cristina 
Published: March 2020

Background and aims. Obesity is associated with numerous pathological conditions, including venous thromboembolism (VTE). VTE is a multifactorial disease; more than half of the hospitalized patients are at risk for VTE.
We aimed to assess the risk of VTE associated with obesity, taking into account the class of obesity (according to the body mass index), gender, age and the intervention of other acquired risk factors.
Method. A case-control study including 732 patients was designed. Collected data included: age, gender, body mass index, pregnancy/ postpartum state, use of hormonal therapy, personal and family history of VTE, smoking, prolonged immobilization and the presence of comorbidities- acquired risk factors for VTE. The risk of VTE was expressed as odds ratio (OR) with 95% confidence interval. Multiple logistic regression analysis was used to detect the independent risk factors. P value < 0.05 was considered significant statistic.
Results. Obesity was associated with a 6.2- fold increased risk for VTE. The risk of VTE associated with obesity was highest in patients aged >50 years and in cases included in classes II and III of obesity. The interaction between obesity and another acquired risk factor has almost doubled the risk of VTE. Multivariate logistic regression analysis showed obesity as an independent risk factor for VTE for both female and male patients.
Conclusion. Obesity is an independent and moderate risk factor for VTE. The risk increases with body mass index, age and the presence of other acquired risk factors.
Local staging of prostate cancer with multiparametric-MRI: accuracy and inter-reader agreement
Authors: Popita Cristian , Popiţa Anca-Raluca , Andrei Adina , Rusu Adriana , Petruţ Bogdan , Kacso Gabriel , Bungărdean Cătălina , Bolog Nicolae , Coman Ioan 
Published: March 2020

Background. The accuracy of prostate cancer local staging at the time of diagnosis directly influences patient prognosis and treatment.
Aim. To evaluate the diagnostic performance and interobserver variability of mp-MRI in local staging of prostate cancer, using the histopathologic findings at prostatectomy as the reference standard.
Methods. Fifty patients (mean age 64.4±7.2) with biopsy confirmed prostate cancer were included in this prospective study. All patients were examined with mp-MRI before radical prostatectomy and images were read by three independent radiologists. Sensitivity (Se), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV), and accuracy rate were calculated and compared for all three readers. Interobserver agreement was evaluated using Kappa Cohen coefficient of agreement.
Results. The overall Se, Sp, PPV, NPV and accuracy rates for detecting extraprostatic tumor extension (EPE) ranged between 76.5-94.1%, 45.5-84.9%, 43.8-76.2%, 83.3-96.6% and 58-88%. For evaluation of seminal vesicle invasion (SVI), the overall Se, Sp, PPV, NPV and accuracy rates ranged between 57.1-85.7%, 86.1-97.7%, 40.0-85.7%, 92.5-97.7% and 82-96%, respectively. The overall Kappa Cohen coefficient of agreement varied between 0.349-0.638 for EPE and between 0.507-0.668 for SVI.
Conclusions. Our results showed that 1.5T mp-MRI is a reliable method for local staging of prostate cancer, with good diagnostic performance in detecting EPE and SVI. The overall interobserver agreement rates between readers with the same level of experience in prostate MRI ranged from fair to good in the evaluation of EPE and from moderate to good for the assessment of SVI.

Conclusions. Our results showed that 1.5T mp-MRI is a reliable method for local staging of prostate cancer, with good diagnostic performance in detecting EPE and SVI. The overall interobserver agreement rates between readers with the same level of experience in prostate MRI ranged from fair to good in the evaluation of EPE and from moderate to good for the assessment of SVI.
Management of Enamel Hypomineralization with Resin Infiltration Technique: A Clinical Case Report
Authors: Şişmanoğlu DDS, PhD Soner 
Published: March 2020

Defects that occur during the development of anterior teeth are often associated with aesthetic problems. Although enamel hypomineralization does not significantly increase the risk of caries, it causes patients to experience psychosocial problems. A 23-year-old female patient presented to our clinic complaining of white opacity and discolorations in her anterior teeth. After the systemic and dental anamnesis of the patient, minimally invasive treatment of resin infiltration was planned. In addition, anterior composite resin restorations with impaired color matching was renewed. The patient was recalled 13 months after the treatment. A significant decrease was observed in the appearance of enamel hypomineralizations. The patient was satisfied with the outcome of the treatment. Furthermore, the durability of the treatment after 13 months is satisfactory.
Угорські запозичення в західноукраїнських топонімічних переказах
Authors: МУШКЕТИК ЛЕСЯ 
Published: March 2020

The oral folk prose of Transcarpathia is a valuable source of history and culture of the region. Supplementing the written sources, it has maintained popular attitudes towards events, giving assessments and interpretations that are often different from the official one. In the Ukrainian oral tradition, we find many words borrowed from other languages, in particular Hungarian, which reflects the long period of cohabitation as well as shared historical events and contacts. They also occur in local toponymic legends, which in their own way explain the origin of the local names and are closely linked with the life and culture of the region, contain a lot of ethnographic, historical, mythological, and other information. They are represented mainly by lexical borrowings, Hungarian proper names and realities, which were transformed, absorbed and modified in another system, and, among other things, has served the originality of the Transcarpathian folklore. The process of borrowing the Hungarianisms is marked by heterochronology and a significant degree of assimilation in the receiving environment.
It is known about the long-lasting contacts of the Hungarians with Rus at the time of birth of the homeland - the Honfoglalás, as evidenced by the current geographical names associated with the heroes of the events of that time - the leaders of uprisings Attila, Almash, Prince Latorets (the legends Almashivka, About the Laborets and the White Horse Mukachevo Castle). In the names of toponymic legends and writings there are mentions of the famous Hungarian leaders, the leaders of the uprisings - King Matthias Corvinus, Prince Ferenc Rákóczi II, Lajos Kossuth (the legends Matyashivka, Bovtsar, Koshutova riberiya). Many names of villages, castles and rivers originate from Hungarian lexemes and are their derivatives, explaining the name itself (narratives Sevlyuskyy castle, Gotar, village Gedfork). The times of the Tatar invasion were reflected in the legends The Great Ravine Bovdogovanya and The village Goronda. Sometimes, the nomination is made up of two words - Ukrainian and Hungarian (Mount Goverla, Canyon Grobtedie). In legends, one can find mythological and legendary elements.
The process of borrowing Hungarianisms into Ukrainian is marked by heterochronology, meanwhile borrowings remain unchanged only partially, and in general, they are assimilated in accordance with the phonetic and morphological rules of the Ukrainian language. Consequently, this is a creative process, caused by a number of different factors - social, ethnocultural, aesthetic, etc. In the course of time, events and characters in oral narratives are erased from human memory, so they can be mixed, modified and updated, adapting to new realities.
Лексичні засоби позначення дитячого віку в писемних пам’ятках української мови ХVІ-ХVІІІ ст.
Authors: ЗЕЛІНСЬКА ОКСАНА 
Published: March 2020

Research devoted to childhood as a social-cultural phenomenon has become more active in present-day science. Scientists study some peculiarities of the perception of child and childhood by society in different historical epochs, try to fix childhood limits and to define age periods within child age, and make a conclusion that in many cases, periods of man's life are correlated with social roles of people rather than with biological age, and they were formed under the influence of social institutes developing together with the evolution of society.
The present paper analyzes lexical means used in written records of the Ukrainian language in the 16th-18th centuries to denote child age and express the concept of an age differentiation of childhood. The written records of the Ukrainian language of different genres in the mentioned period were the sources of the research: e.g. business language records, P. Berynda's dictionary, religious texts, sermons, and poetic works.
Lexical units expressing child age to denote childhood as an age period of man's life and general names originating from colloquial language and taken from Church Slavonic were used to denote children. Written sources confirm an active use of hypocoristic forms.
The lack of a clear classification of childhood into separate age periods is seen in the system of children's names. Most of the general names denoting children did not represent an age gradation of childhood and only some words were special names of a child expressing an age characteristic: those were the names of a newly-born child and a baby.
Some adjectives combination with nouns to denote children indicated a relative age characteristic (little, minor) but the contexts in which phrases with the adjective little were used did not give a reason to distinguish between a little child and a young man.
In several sources, a seven-year period was classified as a special stage in a child's life, first of all, due to religious practice. According to Christian tradition, a child was considered to have no sins until the age of 7 since he or she cannot distinguish between good and bad. After that, he or she had to shrive. In secular practice, the age of 7 became the time when a child would be sent to an educational institution. The texts of pedagogical orientation prove the synonymy of common names denoting children with special names of the individuals who get education.
A differentiation according to an age characteristic “adulthood” vs. “minority” can be seen clearly, which is explained by the legal status of an adult and, correspondingly, is expressed by the corresponding lexical denotations. The vocabulary denoting this age period is mostly represented by sources written in business language.
One can see that lexical semantics, with help of which child age is marked in records of the Ukrainian language in the 16th-18th centuries, gives a general concept of childhood common for Ukrainian and European social communities of that time.
Surface Deformation Related to the 2019 Mw 7.1 and 6.4 Ridgecrest Earthquakes in California from GPS, SAR Interferometry, and SAR Pixel Offsets
Authors: Fielding Eric Jameson , Liu Zhen , Stephenson Oliver L. , Zhong Minyan , Liang Cunren , Moore Angelyn , Yun Sang-Ho , Simons Mark 
Published: March 2020

Abstract
We analyzed Synthetic Aperture Radar (SAR) images from Copernicus Sentinel-1A and 1B satellites operated by the European Space Agency and the Advanced Land Observation Satellite-2 (ALOS-2) satellite operated by the Japan Aerospace Exploration Agency and Global Navigation Satellite System (GNSS) data from the Network of the Americas for the 4 July 2019 Mw 6.4 and 5 July (local; 6 July UTC) Mw 7.1 Ridgecrest earthquakes. We integrated geodetic measurements for the 3D vector field of coseismic surface deformation for the two events, using SAR data from Sentinel-1 and ALOS-2 satellites. We combined less precise large-scale displacements from SAR images by pixel offset tracking or matching, including the along-track component, with the more precise SAR interferometry (Interferometric Synthetic Aperture Radar [InSAR]) measurements in the radar line of sight (LoS) direction and intermediate-precision along-track InSAR to estimate all three components of the surface displacement for the two events together. We also estimated the coseismic deformation for the two earthquakes from time-series processing of continuous Global Navigation Satellite System data stations in the area. InSAR coherence and coherence change maps the surface disruptions due to fault ruptures reaching the surface. Large slip in the Mw 6.4 earthquake was on a NE-striking fault that intersects with the NW-striking fault that was the main rupture in the Mw 7.1 earthquake. The main fault bifurcates towards the southeast ending 3 km from the Garlock Fault. The Garlock fault had triggered slip of about 20 mm in the radar LoS along a short section directly south of the main rupture. About 3 km northwest of the Mw 7.1 epicenter, the surface fault separates into two strands that form a pull-apart with about 1 m of down-drop. Further northwest is a wide zone of complex deformation.
PLANEJAMENTO FAMILIAR: PERSPECTIVA DE AÇOES A SEREM IMPLEMENTADAS NA ESF
Authors: Oliveira Priscila Cristina Ávila , Oliveira André Felipe Andrade , Zague Josiane Maria Thomaz , Brito Karina Maria , Silva Nataly Oliveira , Vilela Simone Aparecida Sá 
Published: March 2020

Revisao integrativa de literatura sobre o planejamento familiar. O trabalho mostra diferentes ações que foram realizadas em unidades de saúde e obtiveram resultados positivos como levantamentos estatísticos, ações realizadas com os profissionais da saúde, com capacitações, e também ações diretamente com a população com palestras, consultas médicas e de enfermagem, ações intersetoriais, visitas dos ACS.
Programy resocjalizacyjne realizowane w polskich zakładach poprawczych i schroniskach dla nieletnich oraz ich ewaluacja
Authors: Bernasiewicz Maciej , Noszczyk-Bernasiewicz Monika 
Published: March 2020

Artykuł składa się z dwóch części. W pierwszej scharakteryzowano rodzaje programów resocjalizacyjnych realizowanych w zakładach poprawczych i schroniskach dla nieletnich na terenie całego kraju. Bogactwu pomysłów, wielkiej różnorodności, szeroko realizowanej współpracy ze środowiskiem otwartym nie towarzyszy równie wysoki poziom ewaluacji programów. Autorzy prezentowanych programów, pisząc o efektywności resocjalizacyjnej swoich programów (jej analizie poświęcona jest część druga tekstu), powołują się na następujące jej wskaźniki: nabycie przez wychowanków określonej wiedzy, nowych i przydatnych umiejętności oraz określonych kompetencji społecznych. Odnotowanie tych wskaźników jest dla autorów programów jednoznaczne z uzyskaniem satysfakcjonującego rezultatu w procesie resocjalizacji. Formą rejestracji wskaźników jest w większości przypadków zastosowanie obserwacji niekontrolowanej (niestandaryzowanej). Tylko 9 programów na 59 posiadało formę ewaluacji opartą o narzędzia, które nie są obarczone takimi niedostatkami metodologicznymi, jak obserwacja niekontrolowana i były to: ankieta, test oraz studium indywidualnych przypadków. 9 programów nie posiadało żadnej formy ewaluacji, zaś w 20 zastosowano obserwację żywiołową (potoczną).
Dualizm systemu norm i wartości na przykładzie rozumienia pojęcia patriotyzmu przez pseudokibiców oraz przejawów radykalizacji zachowań
Authors: Michel Małgorzata , Moksa Iwona 
Published: March 2020

Celem artykułu jest zaprezentowanie wyników badań realizowanych w Krakowie w grupie pseudokibiców, dotyczących rozumienia pojęcia patriotyzmu i jego realizacji w aktywności pseudokibicowskiej. Punktem wyjścia jest założenie, że specyficzne rozumienie patriotyzmu ma swoje konsekwencje w postaci konkretnych zachowań, związanych często z mową nienawiści, nawoływaniem do przestępstw z nienawiści i z tym wszystkim, co nazywamy radykalizacją. Taka sytuacja powoduje duże napięcie i poczucie winy, które jest neutralizowane przez stosowanie technik mających na celu jego zminimalizowanie. Z perspektywy koncepcji Davida Matzy i Greshama M. Sykesa (1957) autorki starają się pokazać, w jaki sposób rozdźwięk pomiędzy emocjami i wiedzą a zachowaniem neutralizowany jest przez respondentów.
Manajemen Ekstravasasi Kemoterapi
Authors: Parade Nur Nubli Julian , Pradjoko Isnu 
Published: March 2020

Extravasation is a problem for patient receiving chemotherapy. This will cause pain, ulcer, necrosis and might be a permanent disability. Extravasation is a leakage of a fluid or medicine to the surrounding subcutaneous tissue of the vein or vascular, that may cause skin or tissue necrotic. There was a wide span of incidence data of extravasation on the literature, between 0,01% and 11% reported from child to adult. Management of extravasation was based on proper maintenance of the intravenous (IV) line and application of cold or warm compresses, plus the use of antidotes when available. Antidotes for extravasation that have been shown to be useful are sodium thiosulfate for nitrogen mustard, dimethylsulfoxide for anthracyclines and mitomycin, and hyaluronidase for the vinca alkaloids. New treatments include dexrazoxane, sargramostim, and hyperbaric oxygen for doxorubicin extravasations. In order to improve patient service quality and reduce morbidity, every medical staff handle cancer patient receiving chemotherapy should have sufficient knowledge about how to manage extravasation event