bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acculturation, education, and gender roles: evidence from Canada
Authors: Kessler Anke S , Milligan Kevin 
Published: June 2020

Abstract
This article studies the influence of cultural norms on economic outcomes. We combine detailed information on second-generation female immigrants with historical data from their ancestral source countries to see how the cultural endowment affects current decisions on work and fertility. We show that results using the standard approach are somewhat sensitive to context and specification. We then extend to reveal an education gradient for cultural assimilation: lower-educated women exhibit a strong influence of cultural variables while higher-educated women show no influence at all. We gather and present evidence on several potential mechanisms for the education gradient.
CodonAdjust: a software for in silico design of a mutagenesis library with specific amino acid profiles
Authors: Nguyen Thuy Duong , Saito Yutaka , Kameda Tomoshi 
Published: June 2020

Abstract
In protein engineering, generation of mutagenesis libraries is a key step to study the functions of mutants. To generate mutants with a desired composition of amino acids (AAs), a codon consisting of a mixture of nucleotides is widely applied. Several computational methods have been proposed to calculate a codon nucleotide composition for generating a given amino acid profile based on mathematical optimization. However, these previous methods need to manually tune weights of amino acids in objective functions, which are time-consuming and, more importantly, lack publicly available software implementations. Here, we develop CodonAdjust, a software to adjust a codon nucleotide composition for mimicking a given amino acid profile. We propose different options of CodonAdjust, which provide various customizations in practical scenarios such as setting a guaranteeing threshold for the frequencies of amino acids without any manual tasks. We demonstrate the capability of CodonAdjust in the experiments on the complementarity-determining regions (CDRs) of antibodies and T-cell receptors (TCRs) as well as millions of amino acid profiles from Pfam. These results suggest that CodonAdjust is a productive software for codon design and may accelerate library generation. CodonAdjust is freely available at https://github.com/tiffany-nguyen/CodonAdjust. Paper edited by Dr. Jeffery Saven, Board Member for PEDS.
More on the infrared renormalon in SU (N) QCD(adj.) on $\mathbb{R}^3\times S^1$
Authors: Ashie Masahiro , Morikawa Okuto , Suzuki Hiroshi , Takaura Hiromasa 
Published: June 2020

Abstract
We present additional observations to previous studies on the infrared (IR) renormalon in $SU(N)$ QCD(adj.), the $SU(N)$ gauge theory with $n_W$-flavor adjoint Weyl fermions on $\mathbb{R}^3\times S^1$ with the $\mathbb{Z}_N$ twisted boundary condition. First, we show that, for arbitrary finite $N$, a logarithmic factor in the vacuum polarization of the “photon” (the gauge boson associated with the Cartan generators of $SU(N)$) disappears under the $S^1$ compactification. Since the IR renormalon is attributed to the presence of this logarithmic factor, it is concluded that there is no IR renormalon in this system with finite $N$. This result generalizes the observation made by Anber and Sulejmanpasic [J. High Energy Phys. 1501, 139 (2015)] for $N=2$ and $3$ to arbitrary finite $N$. Next, we point out that, although renormalon ambiguities do not appear through the Borel procedure in this system, an ambiguity appears in an alternative resummation procedure in which a resummed quantity is given by a momentum integration where the inverse of the vacuum polarization is included as the integrand. Such an ambiguity is caused by a simple zero at non-zero momentum of the vacuum polarization. Under the decompactification $R\to\infty$, where $R$ is the radius of the $S^1$, this ambiguity in the momentum integration smoothly reduces to the IR renormalon ambiguity in $\mathbb{R}^4$. We term this ambiguity in the momentum integration “renormalon precursor”. The emergence of the IR renormalon ambiguity in $\mathbb{R}^4$ under the decompactification can be naturally understood with this notion.
Factors Associated With the Outcome of a First-Line Intervention for Patients With Hip or Knee Osteoarthritis or Both: Data From the BOA Register
Authors: Dell’Isola Andrea , Jönsson Therese , Nero Håkan , Eek Frida , Dahlberg Leif 
Published: June 2020

Abstract

Objective
This study explored the association of patients’ demographics, health status, symptom severity, previous osteoarthritis (OA) care, and psychological status with the change in pain severity following a first-line intervention including education and exercise for OA provided nationwide in Swedish primary care.

Methods
This register-based cohort study included 23,309 people with knee or hip OA from the Better Management of Patients with OA register. Linear regression models were used to assess the association of independent variables with the change in pain from baseline to 3 and 12 months. All the analyses were stratified based on the affected joint (hip vs knee).

Results
In people with hip and people with knee OA, high levels of baseline pain were associated with decreased pain at both follow-ups (3 months: knee B = −.67; hip B = −.64; 12 months: knee B = −.70; hip B = −.66), whereas being older, overweight, or female had a weak or no association. Finally, at both follow-ups, bilateral OA was associated with increased pain only in people with knee OA, whereas comorbidities and the willingness to undergo surgery were associated with increased pain regardless of the affected joint.

Conclusions
Baseline pain showed the strongest association among the analyzed variables, whereas sex, age, and body mass index appear to be weakly associated with the pain change after a first-line intervention. Comorbidities and willingness to undergo surgery showed a potentially important association and may have a negative impact on the pain change following a first-line intervention.

Impact
In people with hip or knee OA, age, sex, body mass index, and previous surgery are only weakly associated with the change in pain after a first-line intervention supporting the evidence recommending exercise and education as a foundation for all OA therapy. Having comorbidities and being willing to undergo surgery is associated with a worse outcome from a first-line intervention, including exercise and education. Individualized treatments addressing the disease perception and the specific comorbidity profile may improve the outcomes.
Threatening increase in alcohol consumption in physicians quarantined due to coronavirus outbreak in Poland: the ALCOVID survey
Authors: Silczuk Andrzej 
Published: June 2020

ABSTRACT

Background
The potential risks of increased alcohol use and of the development of alcohol dependence during COVID-19 pandemic were identified. So far there have been no studies concerning pandemic influence on alcohol consumption in medical professionals in quarantine or isolation.

Methods
The 12 point ‘online’ ALCOVID survey with a cover letter was designed and addressed to physicians, recruited online via accessible networks, who underwent isolation or quarantine during recent pandemic. The AUDIT-3 scale was included.

Results
A representative trial of 113 physicians participated in the study. Over 53% of screened doctors revealed that the amounts of the consumed alcohol have escalated; almost 20% of subjects binged over seven standard drinks for one occasion. Close to every second used six or more drinks on one occasion. Over 40% used alcohol more than four times per week. Female used alcohol more often and more standard drinks per occasion. Male binged more. Anxiety and hopelessness were the most common motives to drink.

Conclusions
Alcohol consumption in physicians in quarantine has threateningly increased. It is important to identify the group of people at the risk of problem drinking and dependence development, especially when it concerns key professional branches in the fight against the current crisis.
Total Positivity in Springer Fibres
Authors: Lusztig G 
Published: June 2020

Abstract
Let u be a unipotent element in the totally positive part of a complex reductive group. We consider the intersection of the Springer fibre at u with the totally positive part of the flag manifold. We show that this intersection has a natural cell decomposition which is part of the cell decomposition (Rietsch) of the totally positive flag manifold.
ASSESSMENT OF OCCUPATIONAL EXPOSURE OF RADIATION WORKERS AT A TERTIARY HOSPITAL IN ANHUI PROVINCE, CHINA, DURING 2013–18
Authors: Zhang Guoliang , Shen Jianmin , Bao Pin , Yao Ziqin , Yuan Yuan , Fang Shiyuan 
Published: June 2020

Abstract
Data on occupational radiation exposure of radiation workers at a tertiary hospital in China during 2013–18 were analyzed to provide decision-making advice for hospitals and health administrative departments. A total of 1255 exposure records of radiation workers were collected. The average annual effective doses of radiation workers during 2013–18 was 0.4977 mSv, with 1150 (91.63%) records ranging between 0 and 1 mSv, 91 (7.25%) between 1 and 2 mSv, 10 (0.80%) between 2 and 5 mSv and 4 (0.32%) records exceeding 5 mSv. There was a significant difference in the average annual effective dose of radiation workers among different occupational categories except in 2015 indicating that hospitals and administrative authorities should pay more attention to the radiation workers in the nuclear medicine and intervention department. The average annual effective doses did not show significant differences between male and female workers except in 2017; in that year the average individual dose of female workers was higher than male workers’. There were no significant differences in the average annual effective doses among doctors, nurses and radiologic technologists except in 2016 and 2017; during that period the individual dose of nurses was higher than doctors’ and radiologic technologists’.
Reduced Hippocampal Volume and Its Relationship With Verbal Memory and Negative Symptoms in Treatment-Naive First-Episode Adolescent-Onset Schizophrenia
Authors: Duan Xujun , He Changchun , Ou Jianjun , Wang Runshi , Xiao Jinming , Li Lei , Wu Renrong , Zhang Yan , Zhao Jingping , Chen Huafu 
Published: June 2020

Abstract
Accumulating neuroimaging evidence has shown remarkable volume reductions in the hippocampi of patients with schizophrenia. However, the relationship among hippocampal morphometry, clinical symptoms, and cognitive impairments in schizophrenia is still unclear. In this study, high-resolution structural magnetic resonance imaging data were acquired in 36 patients with adolescent-onset schizophrenia (AOS, age range: 13–18 years) and 30 age-, gender-, and education-matched typically developing controls (TDCs). Hippocampal volume was assessed automatically through volumetric segmentation and measurement. After adjusting for total intracranial volume, we found reduced hippocampal volume in individuals with AOS compared with TDCs, and the hippocampal volume was positively correlated with verbal memory and negatively correlated with negative symptoms in AOS. In addition, mediation analysis revealed the indirect effect of hippocampal volume on negative symptoms via verbal memory impairment. When the negative symptoms were represented by 2 dimensions of deficits in emotional expression (EXP) and deficits in motivation and pleasure (MAP), the indirect effect was significant for EXP but not for MAP. Our findings provide further evidence of hippocampal volume reduction in AOS and highlight verbal memory impairment as a mediator to influence the relationship between hippocampal morphometry and negative symptoms, especially the EXP dimension of negative symptoms, in individuals with AOS.
When Do Unions Matter to Social Policy? Organized Labor and Leave Legislation in US States
Authors: Engeman Cassandra 
Published: June 2020

AbstractTrade union institutions are historically and comparatively weak in the United States, and union membership has been in steady decline over several decades. Scholars thus question the contemporary relevance of organized labor to social policy. Yet, there is considerable state-level variation in social policy and union institutional strength that remains underexamined. Focusing on variability across US states, this paper uses mixed-methods analysis to examine relationships between organized labor and parental and family leave legislation under varying political conditions. Event history analysis of state-level leave policy adoption from 1983 to 2016 shows that union institutional strength, particularly in the public sector, is positively associated with the timing of leave policy adoption. These findings are robust to the inclusion of other factors, including Democratic control of state houses, which is also shown to facilitate leave policy adoption. Comparative case studies support event history findings and illustrate how state house partisanship informs the level of government that leave advocates target for policy change. The paper concludes by suggesting further attention to subnational policies and investigation into the social movement practice of target-shifting and its effects. Ultimately, the paper demonstrates the operation of power resources at the subnational level within a liberal market national context.
The Townscape Movement and the Politics of Post-War Urbanism
Authors: Subramanian Divya 
Published: June 2020

Abstract
This article examines the political and aesthetic significance of the Townscape movement, an architectural and planning movement that emerged in the 1940s and advocated for urban density, individuality, and vibrant street life. Townscape’s vernacular, human-scale vision of urban life was a significant strand in post-war planning culture, one that existed alongside the archetypal forms of social democratic planning, from new towns to tower blocks. By examining the writings of key Townscape figures associated with the Architectural Review, this article argues that Townscape engaged with the tensions at the heart of the post-war social democratic project—individualism versus community, debates over expertise and authority, and responses to the culture of affluence. In doing so, it contributes to a broader urban historiography on the post-war ‘return to the city’, showing how post-war urbanism, usually depicted as an American phenomenon centred around the figure of Jane Jacobs, had its counterpart in a uniquely British planning movement.
How does varying water supply affect oxygen isotope variations in needles and tree rings of Scots pine?
Authors: Timofeeva Galina , Treydte Kerstin , Bugmann Harald , Salmon Yann , Rigling Andreas , Schaub Marcus , Vollenweider Pierre , Siegwolf Rolf , Saurer Matthias 
Published: June 2020

AbstractIn many regions, drought is suspected to be a cause of Scots pine decline and mortality, but the underlying physiological mechanisms remain unclear. Because of their relationship to ecohydrological processes, δ18O values in tree rings are potentially useful for deciphering long-term physiological responses and tree adaptation to increasing drought. We therefore analyzed both needle- and stem-level isotope fractionations in mature trees exposed to varying water supply. In a first experiment, we investigated seasonal δ18O variations in soil and needle water of Scots pine in a dry inner Alpine valley in Switzerland, comparing drought-stressed trees with trees that were irrigated for more than 10 years. In a second experiment, we analyzed twentieth-century δ18O variations in tree rings of the same forest, including a group of trees that had recently died. We observed less 18O enrichment in needle water of drought-stressed compared with irrigated trees. We applied different isotope fractionation models to explain these results, including the Péclet and the two-pool correction, which considers the ratio of unenriched xylem water in the needles to total needle water. Based on anatomical measurements, we found this ratio to be unchanged in drought-stressed needles, although they were shorter. The observed lower 18O enrichment in needles of stressed trees was therefore likely caused by increased effective path length for water movement within the leaf lamina. In the tree-ring study, we observed lower δ18O values in tree rings of dead trees compared with survivors during several decades prior to their death. These lower values in declining trees are consistent with the lower needle water 18O enrichment observed for drought-stressed compared with irrigated trees, suggesting that this needle-level signal is reflected in the tree rings, although changes in rooting depth could also play a role. Our study demonstrates that long-term effects of drought are reflected in the tree-ring δ18O values, which helps to provide a better understanding of past tree physiological changes of Scots pine.
Possible Impact of COVID-19 on Children in Africa, Reflections from Italy and Burkina Faso
Authors: Ouedraogo Paul , Schumacher Richard Fabian 
Published: June 2020

Abstract
Africa is the World Health Organization-region least affected by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic. Here, we compare the situation in severely hit Italy with that in less hit Burkina Faso, focussing on the differences in epidemiological, geographical, demographical, cultural and medical conditions to highlight how a full-blown war on the pandemic can impact on other, equally important aspects of global child health.
Conservation genetics of native and European-introduced Chinese water deer (Hydropotes inermis)
Authors: Putman Rory , Dunn Nicholas , Zhang Endi , Chen Min , Miquel Christian , Savolainen Vincent 
Published: June 2020

AbstractSufficient genetic variation is vital for the long-term survival of a population. The adaptive potential and reproductive fitness of a population is generally enhanced by greater levels of genetic diversity, while loss of genetic variation in small populations may increase extinction risk due to disease susceptibility and decreased reproductive fitness. Determining levels of genetic diversity in threatened species can, therefore, help inform conservation strategies. The Chinese water deer (Hydropotes inermis) is classified as Vulnerable in its native range on the IUCN Red List, and populations in Korea and mainland China have declined drastically in recent years. However, the species was introduced to Europe about a century ago and populations there now make up over 40% of global numbers. To infer the population genetic structure and genetic diversity of Chinese water deer both in their native China and in populations introduced to the UK and France, variation in mitochondrial DNA was investigated for over 100 individuals (92 cytochrome b and 106 control region sequences). Our results reveal lower levels of genetic diversity in the British populations, differentiation between native and introduced populations, and that the source population of British deer is likely to be extinct. Recommendations are made for the conservation of populations.
When to Do Surgery and When Not to Do Surgery for Endometriosis: A Systematic Review and Meta-analysis
Authors: Leonardi Mathew , Gibbons Tatjana , Armour Mike , Wang Rui , Glanville Elizabeth , Hodgson Ruth , Cave Adele E. , Ong Jozarino , Tong Yui Yee Felice , Jacobson Tal Z. , Mol Ben W. , Johnson Neil P. , Condous George 
Published: June 2020

(Abstracted from J Minim Invasive Gynecol 2020;27:390–407)
Endometriosis is an inflammatory disease characterized by endometrium-like lesions outside the uterus. Pelvic pain and infertility are hallmarks of the disorder.
The Effects of Propofol on Neural Responses in the Mouse Primary Auditory Cortex
Authors: Du Fang , Xu Ninglong , Wang Kai , Liang Chao , Miao Changhong 
Published: June 2020

Objective:
Two-photon laser-scanning microscopy allows for the monitoring of all brain neurons with single-cell and single-action potential accuracy. This study aimed to investigate the neural responses of the primary auditory cortex to sound stimuli in awake and propofol-anesthetized mice using 2-photon laser-scanning microscopy.

Methods:
Twelve healthy adult male C57BL/6 mice were used in the present study. In each mouse, the scalp was removed over the entire dorsal skull, and the right primary auditory cortex (A1) located. The test stimulus, used in the awake and propofol-induced anesthetic state, was a group of tones with a random combination of 3 sound intensities and 8 sound frequencies. The calcium indicator GCaMP6s was virally expressed in cortical neurons and neuronal activity was recorded using 2-photon imaging.

Results:
Calcium responses to sound stimuli in two thirds of the neuronal population of the A1 layer were significantly inhibited by propofol anesthesia. In a single neuron, the calcium responses were also inhibited by propofol anesthesia. In the waking state, △F/F (where F is the time series of fluorescence intensity) of all single neurons was significantly higher than that in the propofol-induced anesthetic state (n=669, P<0.001). Finally, in one example session and averaged across different fields of views (n=6 sessions), the response events to sound stimuli were also inhibited by propofol anesthesia.

Conclusion:
Anesthetic doses of propofol inhibited calcium transients and neuronal activity in the primary auditory cortex of mice.
Second Place Award: Long-term patient-reported outcomes after intramedullary Kirschner-wire fixation for displaced subcapital fractures of the fifth metacarpal bone: A retrospective cohort study
Authors: van Bussel Erik M. , Houwert R. Marijn , Kootstra Tom J.M. , van Heijl Mark , Van der Velde Detlef , Wittich Philip , Keizer Jort 
Published: June 2020

Background:
The objective of this study was to analyze complications and patient-reported functional outcome after antegrade intramedullary Kirschner-wire fixation of displaced subcapital fractures of the fifth metacarpal bone.

Methods:
All consecutive patients treated from January 2010 to December 2015 were retrospectively identified using patient logs and radiographic images. Indications for operative fixation were angulation greater than 40 degrees, shortening less than 2 mm, or rotational deficit. Complications were registered from the patient logs. Functional outcome was assessed with the Patient-Rated Wrist/Hand Evaluation (PRWHE) and Disabilities of the Arm, Shoulder and Hand Score (DASH) questionnaires, both ranging from 1-100.

Results:
Fifty-one patients could be included, with two patients lost to follow-up. The mean outpatient follow-up was 9 wk, and the interval for functional assessment was 34 mo with 40 patients (78%) having responded to the questionnaires. Forty-seven patients (92%) proceeded to fracture union, while the recovery of two patients was complicated by migration of the Kirschner wires through the distal cortex into the metacarpophalangeal joint respectively 5 and 6 wk after primary surgery. Eight minor complications were registered, including a superficial skin infection, mild local dysesthesia or a 10- to 20-degree extension lag at the end of outpatient follow-up. Overall, in 41 patients (80%) the Kirschner wires were removed. Long-term functional outcome was excellent with mean PRWHE and DASH scores of, respectively, 3 and 6 points.

Conclusions:
If surgical treatment is considered, we recommend temporary antegrade intramedullary Kirschner wire fixation as a reliable therapeutic method with a low complication rate and excellent long-term functional outcome.

Level of Evidence:
Level III.