bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome composition analysis of multipartite BNYVV reveals the occurrence of genetic re-assortment in the isolates of Asia Minor and Thrace
Authors: Yüksel Özmen Canan , Khabbazi Saber Delpasand , Khabbazi Afsaneh Delpasand , Gürel Songül , Kaya Rıza , Oğuz Muhammet Çağrı , Turan Ferzat , Rezaei Fereshteh , Kibar Umut , Gürel Ekrem , Ergül Ali 
Published: March 2020

AbstractBeet necrotic yellow vein virus (BNYVV) is the cause of rhizomania, an important disease of sugar beet around the world. The multipartite genome of the BNYVV contains four or five single-stranded RNA that has been used to characterize the virus. Understanding genome composition of the virus not only determines the degree of pathogenicity but also is required to development of resistant varieties of sugar beet. Resistance to rhizomania has been conferred to sugar beet varieties by conventional breeding methods or modern genome engineering tools. However, over time, viruses undergo genetic alterations and develop new variants to break crop resistance. Here, we report the occurrence of genetic reassortment and emergence of new variants of BNYVV among the isolates of Thrace and Asia Minor (modern-day Turkey). Our findings indicate that the isolates harbor European A-type RNA-2 and RNA-3, nevertheless, RNA-5 is closely related to East Asian J-type. Furthermore, RNA-1 and RNA-4 are either derived from A, B, and P-types or a mixture of them. The RNA-5 factor which enhance the pathogenicity, is rarely found in the isolates studied (20%). The creation of new variants of the virus emphasizes the necessity to develop new generation of resistant crops. We anticipate that these findings will be useful for future genetic characterization and evolutionary studies of BNYVV, as well as for developing sustainable strategies for the control of this destructive disease.
Interface treatment using amorphous-carbon and its applications
Authors: Choi Myung Sik , Na Han Gil , Bang Jae Hoon , Choi Sun-Woo , Kim Sang Sub , Lee Kyu Hyoung , Kim Hyoun Woo , Jin Changhyun 
Published: March 2020

AbstractBreakthrough process technologies have been introduced that can increase the chemical sensitivity of an interface at which reactions occur without significantly altering the physico-chemical properties of the material. Such an interfacial treatment method is based on amorphous-carbon as a base so that fluids can be deposited, and the desired thickness and quality of the deposition can be ensured irrespective of the interface state of the material. In addition, side effects such as diffusion and decreasing strength at the interface can be avoided. This is simpler than existing vacuum-based deposition technology and it has an unmatched industrial advantage in terms of economics, speed, accuracy, reliability, accessibility, and convenience. In particular, this amorphous-carbon interface treatment technology has been demonstrated to improve gas-sensing characteristics of NO2 at room temperature.
Relative tail length correlates with body condition in male but not in female crowned leafnose snakes (Lytorhynchus diadema)
Authors: Sivan Jaim , Hadad Shlomo , Tesler Itay , Rosenstrauch Avi , Allan Degen Abraham , Kam Michael 
Published: March 2020

AbstractReproductive success is the ultimate measure of individual quality; however, it is difficult to determine in free-living animals. Therefore, indirect measures that are related to reproduction are generally employed. In snakes, males typically possess longer tails than females and this sexual size dimorphism in tail length (TL) has generally been attributed to the importance of the tail in mating and reproduction. Thus, intra-sexual differences in tail length, specifically within males, were hypothesized to reflect individual quality. We used a body condition index (BCI) as a measure of quality in snakes and predicted that tail length would be correlated with BCI in males. We tested our prediction by determining BCI in the free-ranging adult male and female crowned leafnose snake (Lytorhynchus diadema), a colubrid species that inhabits mainly desert sand dunes. The relative TL was correlated positively and significantly to BCI in males (F1,131 = 11.05; r2adj = 0.07;P < 0.01) but not in females, thus supporting our prediction. This is the first time that the relationship between TL and body condition was tested in a free-ranging species. In addition, sexual size dimorphism of TL increased intra-specifically with body size, which was also found in interspecific analyses following Rensch’s rule.
Effects of ayahuasca on mental health and quality of life in naïve users: A longitudinal and cross-sectional study combination
Authors: Jiménez-Garrido Daniel F. , Gómez-Sousa María , Ona Genís , Dos Santos Rafael G. , Hallak Jaime E. C. , Alcázar-Córcoles Miguel Ángel , Bouso José Carlos 
Published: March 2020

AbstractAyahuasca is a hallucinogenic decoction used as a traditional medicine in several Amazonian regions. The ritualistic use of ayahuasca has spread throughout many countries, making it necessary to study its risks and benefits. Two sub-studies were designed for this investigation. In sub-study 1, a psychiatric interview and a battery of questionnaires were administered to subjects (n = 40) before their first ayahuasca use. Two follow-ups were conducted at 1 and 6 months. In sub-study 2, the same interview and battery of questionnaires were administered to long-term ayahuasca users (n = 23) and their scores were compared with those of the ayahuasca-naïve group. In the first assessment, nearly half (45%) of the naïve users were found to meet the diagnostic criteria for a psychiatric disorder. After the ayahuasca use, more than 80% of those subjects showed clinical improvements that persisted at 6 months. The questionnaires showed significant reductions in depression and psychopathology. Regarding sub-study 2, long-term users showed lower depression scores, and higher scores for self-transcendence and quality of life, as compared to their peers in sub-study 1. Further controlled and observational naturalistic studies assessing the eventual risks and potential benefits of ayahuasca are warranted.
Gene presence-absence variation associates with quantitative Verticillium longisporum disease resistance in Brassica napus
Authors: Gabur Iulian , Chawla Harmeet Singh , Lopisso Daniel Teshome , von Tiedemann Andreas , Snowdon Rod J. , Obermeier Christian 
Published: March 2020

AbstractAlthough copy number variation (CNV) and presence-absence variation (PAV) have been discovered in selected gene families in most crop species, the global prevalence of these polymorphisms in most complex genomes is still unclear and their influence on quantitatively inherited agronomic traits is still largely unknown. Here we analyze the association of gene PAV with resistance of oilseed rape (Brassica napus) against the important fungal pathogenVerticillium longisporum, as an example for a complex, quantitative disease resistance in the strongly rearranged genome of a recent allopolyploid crop species. Using Single Nucleotide absence Polymorphism (SNaP) markers to efficiently trace PAV in breeding populations, we significantly increased the resolution of loci influencingV. longisporumresistance in biparental and multi-parental mapping populations. Gene PAV, assayed by resequencing mapping parents, was observed in 23–51% of the genes within confidence intervals of quantitative trait loci (QTL) forV. longisporumresistance, and high-priority candidate genes identified within QTL were all affected by PAV. The results demonstrate the prominent role of gene PAV in determining agronomic traits, suggesting that this important class of polymorphism should be exploited more systematically in future plant breeding.
Long non-coding RNA FENDRR inhibits migration and invasion of cutaneous malignant melanoma cells
Authors: Chen Xu-e , Chen Pu , Chen Shanshan , Lu Jin , Ma Ting , Shi Guang , Sheng Liang 
Published: March 2020

Abstract
The present study aimed to investigate the effects of lncRNA FENDRR on the migration and invasion of malignant melanoma (MM) cells. The expression levels of FENDRR in MM tissues and MM cell lines were detected using qRT-PCR, followed by construction of FENDRR-knocked down and overexpressed stable cells. Then the effects of FENDRR on cell proliferation, migration and invasion were detected using MTT assay and Transwell assay. The protein expression levels of matrix metallopeptidase 2 (MMP2), MMP9, and related factors in JNK/c-Jun pathway were detected using Western blot. FENDRR was down-regulated in MM tissues and cell lines. Besides, its expression levels in different MM cells were diverse. Knockdown of FENDRR facilitated MM cells proliferation, migration and invasion in A375 cells, while overexpressing FENDRR had reverse results. In addition, MMPs and JNK/c-Jun pathway involved in the FENDRR-mediated regulation of MM cell proliferation, migration and invasion. Our results demonstrated that FENDRR mediated the metastasis phenotype of MM cells by inhibiting the expressions of MMP2 and MMP9 and antagonizing the JNK/c-Jun pathway.
Reconstruction of the ground-layer adaptive-optics point spread function for MUSE wide field mode observations
Authors: Fusco T. , Bacon R. , Kamann S. , Conseil S. , Neichel B. , Correia C. , Beltramo-Martin O. , Vernet J. , Kolb J. , Madec P.-Y. 
Published: March 2020

Context. Here we describe a simple, efficient, and most importantly fully operational point-spread-function (PSF)-reconstruction approach for laser-assisted ground layer adaptive optics (GLAO) in the frame of the Multi Unit Spectroscopic Explorer (MUSE) wide field mode.
Aims. Based on clear astrophysical requirements derived by the MUSE team and using the functionality of the current ESO Adaptive Optics Facility we aim to develop an operational PSF-reconstruction (PSFR) algorithm and test it both in simulations and using on-sky data.
Methods. The PSFR approach is based on a Fourier description of the GLAO correction to which the specific instrumental effects of MUSE wide field mode (pixel size, internal aberrations, etc.) have been added. It was first thoroughly validated with full end-to-end simulations. Sensitivity to the main atmospheric and AO system parameters was analysed and the code was re-optimised to account for the sensitivity found. Finally, the optimised algorithm was tested and commissioned using more than one year of on-sky MUSE data.
Results. We demonstrate with an on-sky data analysis that our algorithm meets all the requirements imposed by the MUSE scientists, namely an accuracy better than a few percent on the critical PSF parameters including full width at half maximum and global PSF shape through the kurtosis parameter of a Moffat function.
Conclusions. The PSFR algorithm is publicly available and is used routinely to assess the MUSE image quality for each observation. It can be included in any post-processing activity which requires knowledge of the PSF.
Planet-induced spirals in the circumbinary disk of GG Tauri A
Authors: Phuong N. T. , Dutrey A. , Di Folco E. , Guilloteau S. , Pierens A. , Bary J. , Beck T. L. , Chapillon E. , Denis-Alpizar O. , Diep P. N. , Majumdar L. , Piétu V. , Tang Y.-W. 
Published: March 2020

Context. ALMA high angular resolution observations of the dust and CO emission have already revealed signatures of protoplanets embedded in protoplanetary disks. These detections are around single T Tauri stars, while exoplanet surveys reveal that planets can also form in binary (or multiple) systems, either in circumstellar or circumbinary orbits.
Aims. We searched for indirect evidence for planet formation in the multiple system GG Tau A, which harbors the most massive circumbinary disk among T Tauri stars.
Methods. We performed CO(2–1) ALMA Cycle 6 observations of GG Tau A at 0.3″ resolution. The images confirm the “hot spot” detected at higher frequencies, but also reveal prominent spiral-like features. We modeled these features using the analytic prescription for the linear perturbation regime induced by low-mass planets.
Results. The brightest spiral is well reproduced by a density wave excited by a protoplanet (GG Tau Ac) at the hot-spot location (290 au), just outside the dust ring. The absence of a clear gap (in gas or dust) at the planet location implies that its mass is significantly lower than that of Jupiter, i.e., of about the mass of Neptune or lower. Furthermore, other prominent (trailing) spiral patterns can be represented by adding one (or more) planet(s) at larger orbital radii, with the most obvious candidate located near the 2:1 mean-motion resonance with GG Tau Ac.
Conclusions. The (proto-)planet GG Tau Ac appears to externally confine the ring in a stable configuration, explaining its high mass. Our results also suggest that planets similar in mass to Neptune may form in dense circumbinary disks orbiting (wide) binary stars. In the GG Tau case, orbital resonances appear to play an important role in shaping this multiple circumbinary planet system.
Analysis of floor response spectra of an office building
Authors: Jendzelovsky Norbert , Grmanova Alzbeta 
Published: March 2020

The paper deals with the analysis of an office building located in the outskirts of Bratislava, Slovakia. The building consists of one underground floor and five above ground floors that have been roofed by a steel roof structure. The steel structure represents a subtle roofing of areas with air condition units and other technological equipment. For proper design of the steel structure with respect to the seismic loading, it is necessary to prepare floor response spectra for the top floor. A computer model of reinforced concrete structure was created using the Finite Element Method - FEM. Based on the approved recommendations for dynamic loading, seismic load of the building was defined in the form of a synthetic three-component accelerogram at free field level. The calculations of seismic response spectra were made assuming a linearly elastic behavior of the building structure without considering the elasto-plastic effects during the earthquake. The calculation of transient analysis was performed for a three-component synthetic accelerometer in ANSYS software.
Acceleration time responses in three orthogonal directions (two horizontal and one vertical) were obtained for 6 selected points of the top floor. The obtained values of acceleration were compiled by additional software in order to obtain the resulting floor spectra. Subsequently, the envelope of the floor spectra was created, which has been taken into account in the design of a steel roof structure.
An analysis of patient’s and disease related factors predictive of the outcomes of surgery for carpal tunnel syndrome
Authors: Zyluk Andrzej , Zyluk-Gadowska Paulina , Kolodziej Lukasz , Szlosser Zbigniew 
Published: March 2020

Abstract
Purpose Outcomes of surgery for carpal tunnel syndrome may differ in relation to certain factors like age, duration of symptoms, clinical and electrophysiological severity. The objective of this study was an investigation into the hypothesis that several factors are predictive of results of surgical treatment of the condition.
Methods The pre- and postoperative records of 1,117 patients: 909 women (81 %) and 208 men (19 %) with a mean age of 63 years were analysed. Outcomes recorded in the sensory and functional severity scores of the Levine questionnaire were dichotomized into achieving or not-achieving a minimally clinically important difference. The effect of selected variables: sex, age, duration of symptoms, clinical and electrophysiological severity of and presence of comorbidities on outcomes of surgery at 6 months was investigated.
Results Univariate and multivariate analysis of covariates based on sex, age, duration of the disease and its clinical severity showed female gender and worse baseline symptom severity scores to be significant predictors for an improvement following carpal tunnel syndrome surgery. It showed also younger age, shorter duration of symptoms and higher baseline symptom severity scores to be predictive of a greater improvement of total grip strength, and younger age to be predictive of a greater pain cessation following surgery.
Conclusion Of all considered patient’s and disease related factors, the baseline clinical severity expressed in the Levine symptom severity scores had appeared to be the strongest predictor of better outcomes of surgery for carpal tunnel syndrome.
Sprachstand 4-jähriger Kinder mit Migrationshintergrund in Hessen: quo vadis?
Authors: Zaretsky Eugen , Lange Benjamin P. , Hey Christiane 
Published: March 2020

ZusammenfassungDie nachhaltige Integration von Personen mit Migrationshintergrund ist aktueller denn je. Dabei steht die Bedeutung der Sprache als zentraler Aspekt außer Diskussion. Im Jahr 2018 waren in Hessen ca. 1 091 000 Personen mit nicht deutscher Staatsangehörigkeit registriert. Insgesamt zeigt damit jeder dritte Hesse Migrationshintergrund, im Vorschulalter sogar jeder zweite. Die Tendenz ist angesichts der anhaltenden Einwanderung und der höheren Geburtenrate in nicht deutschen Familien steigend, und damit auch die Zahl der einschulungspflichtigen Kinder mit minimalen Deutschkenntnissen, aber auch mit klinisch abklärungsbedürftigen sprachbezogenen medizinischen Auffälligkeiten wie periphere Hörstörungen. Das Ziel der vorliegenden Studie ist die Bestandsaufnahme der Deutschkenntnisse bei 4-jährigen Kindergartenkindern mit Migrationshintergrund in Hessen, gemessen an Ergebnissen des validierten, normierten Tests „Kindersprachscreening“. Bei klinisch abklärungsbedürftigen Kindern wurde geprüft, inwiefern sie therapeutisch versorgt wurden, ob bereits diagnostizierte Störungen bzw. Krankheiten bei ihnen vorlagen und inwiefern der Therapiebedarf den Kindergarten-ErzieherInnen und Eltern bewusst war.
Qualitätsindikatoren im Notarzteinsatz
Authors: Ramadanov Nikolai , Klein Roman , Aguilar Valdez Abner Daniel , Behringer Wilhelm 
Published: March 2020

Zusammenfassung
Hintergrund Qualitätsindikatoren sind besonders im Notarzteinsatz, der häufig lebensrettenden Charakter hat, von großer Wichtigkeit.
Ziel der Studie Das Ziel war, die Übereinstimmung zwischen notärztlicher Verdachtsdiagnose und Krankenhausentlassungsdiagnose und die diagnosebezogene Behandlungsdauer zu ermitteln, um zu prüfen, ob diese als Qualitätsindikatoren herangezogen werden können.
Material und Methoden 708 Notarzteinsatzprotokolle des Notarztstandorts Bad Belzig im Zeitraum vom 01.07.2013 bis 30.06.2014 und 01.01.2015 bis 31.12.2015 wurden inkludiert. Die Ermittlung der dÜ (diagnostischen Übereinstimmung) erfolgte durch den Konsens dreier erfahrener Notfallmediziner. Die Behandlungsdauer wurde als Zeitintervall zwischen dem Zeitpunkt des Eintreffens des Notarztes und seiner Abfahrt vom Einsatzort berechnet. Die Behandlungsdauer wurde mittels des Mann-Whitney-U-Tests auf signifikante Unterschiede mit weiteren Variablen getestet. Aus der dÜ und der Behandlungszeit konnte die diagnostische Effizienz im Notarzteinsatz (dEffNA) ermittelt werden.
Ergebnisse Die dÜ lag in 69,4% der Fälle vor. Die durchschnittliche Behandlungsdauer alle Einsätze dauerte 21 min. Die dEffNA ergab einen Durchschnittswert für alle Diagnosen von 3,3/min. Der beste Wert für die dEffNA (dEffNA-kurz) unter den 5 untersuchten einsatzbezogenen Entlassungsdiagnosen betrug 13/min für Apoplex und der schlechteste (dEffNA-lang) 1,15/min für hypertensive Entgleisung/Krise. Die Korrektheit der Notarztdiagnose schien unabhängig von der Behandlungsdauer zu sein.
Diskussion Die dEffNA, berechnet aus dÜ und Behandlungszeit, kann als Qualitätsindikator in der präklinischen Notfallmedizin herangezogen werden. Mit dessen Hilfe können problematische Behandlungsfälle identifiziert werden.
Zertifizierung: Dermatochirurgie für Pflegekräfte und Fachangestellte (DDA, BVDD, DGDC)
Authors: Löser C. R. , Gauglitz G. , Dirschka T. 
Published: March 2020

ZusammenfassungPflegekräfte und medizinische Fachangestellte waren in der Weiterbildung auf dermatologischen Fachkongressen hinsichtlich der Dermatochirurgie lange unterrepräsentiert. Dabei spielen sie eine wichtige Rolle in der Verwirklichung einer patientenzentrierten und qualitätsgesicherten ambulanten Versorgung, gerade bei operativen Eingriffen. Deshalb wurden bereits seit 2011 in Zusammenarbeit mit der Deutschen Gesellschaft für Dermatochirurgie (DGDC) dermatochirurgische Weiterbildungsseminare für Pflegekräfte und Fachangestellte auf der jährlichen Fortbildungsveranstaltung in Frankenthal (heute „Derm“) angeboten. Diese Seminare waren nicht nur ausgezeichnet frequentiert, sondern erfreuten sich einer engagierten Mitarbeit der Teilnehmer und haben so zu einer Bedarfsanalyse beigetragen. Auf den gewonnenen Erfahrungen der Interaktion mit den Seminarteilnehmern basiert dieses Curriculum. Zunächst werden die Themen angelehnt an den Praxisablauf chronologisch aufgelistet und im zweiten Abschnitt inhaltlich präzisiert.
Is Catheter Ablation Better Than Antiarrhythmic Drugs for the Treatment of Atrial Fibrillation?
Authors: Natarajan Balaji , Nayak Srishti , Pai Ramdas G. 
Published: March 2020

AbstractLong-standing atrial fibrillation is associated with significant morbidity including stroke and development of heart failure. Patients also report poor quality of life as a result of debilitating symptoms or treatment side effects from antiarrhythmic medications. Radio frequency or cryothermal mediated catheter ablation has a central role in the management of symptomatic patients with paroxysmal or persistent atrial fibrillation. Circumferential pulmonary vein isolation is vital to the success of this therapy and other ancillary techniques have been described, especially for persistent atrial fibrillation. Several randomized controlled studies have been reported over the last two decades studying important clinical outcomes in patients with atrial fibrillation. In this article, we aim to provide a review of the major studies that have helped define the role of catheter ablation in the management of symptomatic atrial fibrillation in patients with both diseased and structurally normal hearts.