bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of the functional results of tongue reconstruction with four kinds of free flaps after radical resection of tongue cancer
Authors: cai yongcong , Li Chao , Zeng Dinfen , Shui ChunYan , Sun RongHao , Zhou YuQiu , Pei Jiao , Liu Wei , Wang Xu , Jiang Jian , Wang Wei 
Published: February 2020

Abstract
Background Surgery is still the treatment of choice for tongue cancer. Tongue reconstruction should be performed immediately after extensive resection of the tumor, which will affect the patient's function. The purpose of this study was to investigate the functional evaluation of four different free flaps in tongue reconstruction after a tongue cancer operation. Methods Forty-eight cases of tongue reconstruction with a radial forearm free(RFF flap), anterolateral thigh(ALT) flap, lateral upper arm free(LAF)flap and deep inferior epigastric artery perforator(DIEP)flap from 2014 to 2018 were analyzed. The speech function, swallowing function, tongue flexibility and patients' satisfaction with the donor area was investigated six months after repair. Results Twenty-one cases with RFF flaps, 18 cases with ALT flaps, 5 cases with LAF flaps and 4 cases with DIEP flaps showed complete flap survival. Speech function:39.6% of the patients exhibited normal speech, 43.8% of the patients exhibited near-normal speech, the RFF flap group was showed better recovery than did the other three groups ( p =0. 195). The degree of tongue flexibility: 37.5% of the patients with normal postoperative tongue flexibility, 43.6% of the patients with slightly limited tongue flexibility,, 16.7% of the patients with severely limited tongue flexibility, The flexibility of the RFF flap was better than that of the other three groups( p =0. 054). Swallowing function:47.9% of the patients had a regular diet, 33.3% of the patients had soft foods, 16.7% patients receive fluid diet, The RFF flap group showed better recovery than did the other three groups ( p =0. 248). Donor satisfaction: 56.2% of the patients were satisfied, 41.7% of the patients were basically satisfied, 100% of the patients with LAF and DIEP flaps were satisfied. This level of satisfaction was better than that in the RFF and ALT flap groups. ( p =0. 039). Conclusion The functional recovery of RFF flap in tongue reconstruction after middle and early stage tongue cancer surgery is better. However, ALT flap has been used more frequently for a large number of tissue defects caused by radical resection of tongue cancer in the advanced stage. Meanwhile, LAF and DIEP flaps can provide a sufficient tissue volume, a conceal scar, fewer complications in the donor area, and both function and beauty, which are easily accepted by patients.
FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma
Authors: Hao Yilong , liu rui 
Published: February 2020

Abstract
Background Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide, and with 500,000 new cases each year. The high risk of lymph node metastasis and local invasion are the main causes to cripples and death of OSCC patients. As potent growth factors, fibroblast growth factors (FGFs) not only exert biological effects for primary epithelial cells, but also make FGF signaling susceptible to being hijacked by cancer cells. However, the precise role of FGF8 and the therapeutic effects of FGF8 in OSCC need to be further investigated. Methods Immunohistochemical staining was performed using in human OSCC tissues. Bioinformatics analysis was performed to analyze the potential FGF8-associated proteins. Migration and invasion of OSCC cells was examined by wounding healing assay and Matrigel assay. Expression of EMT related markers Was examined by immunoblot. Results In this study, we show that FGF8 is upregulated in OSCC tissues and high FGF8 expression was related with a set of clinicopathologic parameters, including age, drinking, and survival time. FGF8 treatment enhances the invasive capability of OSCC cells. Lentivirus-based FGF8 expression promotes OSCC metastasis in a mouse lung metastasis model. Further, mechanistic study demonstrated that FGF8 induces epithelial-mesenchymal transition in OSCC cells. Conclusions These results highlight a pro-metastatic role of FGF8, and underscore the role of FGF8 in OSCC development.
Negative Differential Resistance in Bidirectional Threshold Switching of Ag/HfOx/Pt Device
Authors: jiang zhiguo , Wang Dongliang , Li Yan , Zhang Yong , Chen Xinman 
Published: February 2020

Abstract
In this work, the dependence of negative differential resistance (NDR) on compliance current (Icc) was investigated based on Ag/HfOx/Pt resistive memory device. Tunable conversion from bidirectional threshold switching (TS) to memory switching (MS) were achieved through enhancing Icc. NDR can be observed in TS as Icc is below 800μA but vanishes in MS. The switching voltages and readout windows of TS evolve with Icc. Furthermore, the dynamic conductance (dI/dV) as a function of time in NDR can be well illustrated by capacitor-like relaxation equation, and the relaxation time constant is significantly dependent on Icc. These phenomena were elucidated from viewpoint of nanofilament evolution controlled by Icc as well as nanocapacitor effects originated from nanofilament gap. The Icc-dependent NDR as well as conversion between TS and MS on Ag/HfOx/Pt resistive memory device indicates its potential application as a multifunctional electronic device.
Memantine for prophylaxis of episodic migraine: a systematic review and meta-analysis
Authors: Mondia Mark Willy Llapitan , Espiritu Adrian , Bolaños Martha Lu , Artemio Jr. A. 
Published: February 2020

Abstract
Background Migraine is a common debilitating primary headache. Memantine is a non-competitive N-methyl D-aspartate (NMDA) antagonist that lowers neuronal excitability that could prevent migraine attacks.Objectives This study aimed to determine the efficacy and safety of memantine in patients experiencing episodic migraine attacks using a systematic review and meta-analysis.Methods We searched CENTRAL, MEDLINE, Scopus, Cochrane, LILACS, ClinicalTrials.gov, HERDIN and Google Scholar for relevant studies. Prespecified screening and eligibility criteria for inclusion were applied. Included studies underwent methodological quality assessment. Study design, patient characteristics, interventions given, and relevant outcomes were extracted and synthesized.Results This review included five relevant articles – 2 randomized controlled trials (RCT) and 3 observational studies (1 retrospective case-series, 2 prospective non-randomized open-label single arm trials). There were 109 patients included in the RCTs and 197 patients reported in the observational studies. Pooled data from the 2 RCTs showed that Memantine at 10mg/day decreased the monthly migraine days at 12 weeks compared to placebo with a mean difference of -1.58 [95% confidence interval (CI) -1.84, -1.32]. Observational studies also showed a decrease in migraine days per month with Memantine (5-20mg/day) after 12 weeks [95% CI]: -9.1 [-11, -7.23], -7.2 [-8.85, -5.55], and -4.9 [-6.29, -3.51]. There were no statistically significant adverse drug events (ADE) noted in patients treated with Memantine compared to placebo.Conclusion Memantine may be effective and well-tolerated as prophylaxis for episodic migraine.
Kluyveromyces marxianus as a Probiotic Yeast: A Mini-review
Authors: Homayouni-Rad Aziz , Azizi Aslan , Oroojzadeh Parvin , Pourjafar Hadi 
Published: February 2020

Background:
Yeasts play diverse roles in human life. Since ancient times, these micro
organisms have been used to produce food products and beverages including bread and beer.
Nowadays, the biotechnological products of yeast are some of the main components of commercial
products.

Objective:
Some species of yeast such as Saccharomyces cerevisiae and Saccharomyces boulardii
are recognized as probiotic yeast with extensive applications in the food and drug industries. However,
certain species like Kluyveromyces marxianus are still not recognized as probiotic micro organisms
despite their widespread industrial usage. In this study, the application of K. marxianus in preparing
food and the medicinal product was reviewed in terms of its beneficial or harmful effects.

Methods:
Pub Med, Google Scholar, Scopus, and Science Direct databases were searched by using
“Probiotics”, “Yeast”, and “Kluyveromyces marxianus”.

Results:
The findings suggest that K. marxianus can be recognized as a probiotic yeast species.

Conclusion:
It can be concluded that K. marxianus may be considered as a probiotic micro organism
with a variety of commercial and medical applications.
Antioxidant Properties of Avicennia marina Leaf Extract in Soybean Oil System
Authors: Molaee Mohammad , Sahari Mohammad A. , Kenari Reza E. , Amirkaveei Shiva , Arbidar Elahe 
Published: February 2020

Background:
Despite the widespread use of antioxidants during the storage of oils,
oxidation of fats and fatty foods is still reported to be the main reason for their quality drop. Synthetic
antioxidants such as butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) completely
escape and easily decompose at high temperatures. There are serious problems in relation to
the toxicity of BHA, BHT and tertiary butylhydroquinone (TBHQ), possibly due to their metabolism
and accumulation in organs and tissues. So finding a useful natural antioxidant is of great
importance, and due to the considerable presence of mangrove plant on the Southern Coasts of Iran,
this study aims to investigate the antioxidant properties of Avicennia marina leaves.

Objective:
Evaluation of the antioxidant activity of the Avicennia marina leaf extract and its
comparison with synthetic antioxidant TBHQ.

Methods:
By adding the ethanolic extracts of Avicennia marina leaves at different concentrations (2,
4 and 6 mg/mL) into soybean oil system at room temperature during 20 days and at different
intervals, their peroxide (PV), thiobarbituric acid (TBA), conjugated dienes (CD) and conjugated
trienes (CT), as well as fatty acid profile were measured. Antioxidant activity of the samples was
compared with that of TBHQ sample. Data analysis was performed using SAS, and a comparison of
average data was carried out using least significant difference (LSD) at a level of 0.01.

Results:
The antioxidant activity of 2 and 4 mg/mL concentrations of Avicennia marina leaf extract
in soybean oil was comparable with that of 0.2 mg/mL concentration of synthetic TBHQ. As a result,
this natural antioxidant can be used for the preservation of soybean oil.

Conclusion:
Due to the presence of phenols in the leaves, Avicennia marina leaf extract can be used
as a rich source of natural antioxidants.
Novel Selective Histone Deacetylase 6 (HDAC6) Inhibitors: A Patent Review (2016-2019)
Authors: He Xingrui , Li Zhen , Zhuo Xiao-Tao , Hui Zi , Xie Tian , Ye Xiang-Yang 
Published: February 2020

Background:
Many human diseases are associated with dysregulation of HDACs. HDAC6
exhibits deacetylase activity not only to histone protein but also to non-histone proteins such as α-
tubulin, HSP90, cortactin, and peroxiredoxin. These unique functions of HDAC6 have gained significant
attention in the medicinal chemistry community in recent years. Thus a great deal of effort has
devoted to developing selective HDAC6 inhibitors for therapy with the hope to minimize the side effects
caused by pan-HDAC inhibition.

Objective:
The review intends to analyze the structural feature of the scaffolds, to provide useful information
for those who are interested in this field, as well as to spark the future design of the new
inhibitors.

Methods:
The primary tool used for patent searching is SciFinder. All patents are retrieved from the
following websites: the World Intellectual Property Organization (WIPO®), the United States Patent
Trademark Office (USPTO®), Espacenet®, and Google Patents. The years of patents covered in this
review are between 2016 and 2019.

Results:
Thirty-six patents from seventeen companies/academic institutes were classified into three
categories based on the structure of ZBG: hydroxamic acid, 1,3,4-oxadiazole, and 1,2,4-oxadiazole.
ZBG connects to the cap group through a linker. The cap group can tolerate different functional groups,
including amide, urea, sulfonamide, sulfamide, etc. The cap group appears to modulate the selectivity
of HDAC6 over other HDAC subtypes.

Conclusion:
Selectively targeting HDAC6 over other subtypes represents two fold advantages: it
maximizes the pharmacological effects and minimizes the side effects seen in pan-HDAC inhibitors.
Many small molecule selective HDAC6 inhibitors have advanced to clinical studies in recent years. We
anticipate the approval of selective HDAC6 inhibitors as therapeutic agents in the near future.
Improving Oral Surgery: A Workflow Proposal to Create Custom 3D Templates for Surgical Procedures
Authors: Peditto Matteo , Nucera Riccardo , Rubino Erasmo , Marcianò Antonia , Bitto Marco , Catania Antonio , Oteri Giacomo 
Published: February 2020

Background:
Computer-guided technologies are adopted in various fields of surgery to limit invasiveness and obtain patient benefits in terms of surgery duration and post-operative course. Surgical templates realized through CAD/CAM technologies are widely diffused in implant dentistry. The aim of this work is to propose, beyond implantology, the feasibility of application of 3D printed surgical templates in oral surgery procedures requiring osteotomies (like maxillary cyst enucleation and tooth disimpaction) in order to obtain accurate surgeries, avoid anatomical damage of surrounding structures and decrease patient’s morbidity, using a simple, low-cost protocol of fabrication.

Objective:
To provide a reliable CAD-CAM workflow for the realization of surgical templates in oral surgery.

Methods:
Three clinical scenarios are described: A maxillary canine disimpaction, a mandibular cyst removal, and an orthodontic miniscrew placement. Each one was managed using custom surgical templates realized using the proposed workflow. A Stereolithography (STL) file of maxillary structures was obtained by the use of a 3D medical image processing software (Materialise Mimics 20.0) a segmentation toolbox acquiring RX volumes by Cone-Beam Computed Tomography (CBCT). Digital models of the teeth, acquired as STL files directly, are imported in the same 3D medical image processing freeware (Materialise Mimics 20.0) to merge STL files of maxillary structures and teeth. Data are transported into Blue Sky Plan 4.0 (Blue Sky Bio, LLC), a software for 3D implant guides fabrication, together with the DICOM images package of maxillary volumes to carry out the pre-surgical treatment planning. Anatomical structures at risk are identified; a contour of ideal incision shape and bone osteotomy extent is drawn. Finally, the resulting three-dimensional guide is digitally generated and the surgical guide printed. The resulting 3D template shows the following major features: teeth support, flap management and bone osteotomy design.

Results:
The proposed work-flow aided the surgeon in both pre-operative and intra-operative work phases through accurate virtual planning and the fabrication of precise surgical guides to be used in oral surgery practice. In each clinical scenario, the use of custom 3D templates allowed better control of the osteotomy planes and flap management. No adverse events occurred during both surgical and healing phases.

Conclusion:
The proposed digital workflow represents a reliable and straightforward way to produce a surgical guide for oral surgery procedures. These templates represent a versatile tool in maxillary cyst enucleations, tooth disimpaction, and other surgical procedures, increasing accuracy, minimizing surgical complications, and decreasing patient’s morbidity.
PARADIGMA FISIKA QUR’ANI DALAM TRIDHARMA PERGURUAN TINGGI KEAGAMAAN ISLAM
Authors: Susilayati Muslimah , Mufiq Mufiq , Syamsiyah Barid 
Published: February 2020

This study aims to provide an overview on the application of the 'Qur'ani Physics' paradigm to the implementation of the Tridharma of Islamic Higher Education in Indonesia. Based on the qualitative-descriptive approach, the results of thisstudy suggest that the need for three stages to be carried out in the process of implementing the 'Qur'ani Physics' paradigm; First, the preparation phase, which begins with the equating of perceptions which the output is in the form of a decree on the integration team. Second, the planning phase, which consists of determining the main material, reviewing and revising the curriculum, as well as determining the strategic plan for research and community service. Third, the implementation phase, which consists of research and development, education and learning, as well as community service. With this integration model, the paradigm of the integration with its various philosophical variants is expected to become a solution for various social problems that occur in society. So that, organizing education at the Islamic Higher Education has a distinction with General Higher Education.
Graphical analysis of free-surface wave fields from moving two consecutive posts connected by thin plate
Authors: Bimberekov Pavel 
Published: February 2020

The article presents photographic materials of wave pictures from two consecutive posts of teardrop cross-section and the same posts with a thin plate installed between them, which introduces into consideration not only separate sequentially moving sources, but also reunites them into a single object, interacting along its entire length with the system of waves from the first source. The regularities of the wave field of consecutive posts with a plate in-stalled between them by means of graphic processing are considered. The possibility of finding the front imaginary source of the Kelvin wave pattern forming the ship's wave system at the position of both one and two wave-lengths in front of the top of the bow retaining wave is estimated. A method is proposed for determining the position of the fictitious location of the aft Kelvin wave system of the ship's wave system based on the results of the analysis of the wave field at the characteristic speeds
of movement, leading to the most successfully fixed inter-location of the wave pattern from the bow and aft extremities. There are shown the pictures of moving forward a pair of posts with
a blunt end of a horizontal section at the same speed and photo fixation from a close angle, pictures of moving forward the posts with a plate between them with a blunt end of a teardrop-shaped cross section at a low speed, moving forward posts with a plate at the side with a sharp end of a teardrop-shaped cross section, etc. All presented photographs were taken in the experimental pool of the Siberian state University of water transport (Novosibirsk state Academy of water transport) in 2006.
Analisis Kekerasan Seksual Pada Anak dan Intervensinya oleh Pekerjaan Sosial (Studi Kasus Kekerasan Seksual oleh Keluarga di Lampung)
Authors: Krisnani Hetty , Kessik Gisela 
Published: February 2020

AbstrakKekerasan terhadap anak sampai saat ini marak terjadi. Kekerasan seksual pada anak merupakan salah satu tindakan kekerasan yang cukup mengalami peningkatan. Berdasarkan berbagai data, pelaku kekerasan berasal dari keluarga terdekat yang dimiliki korban. Kasus Kekerasan seksual yang akan dibahas pada saat ini yaitu berkaitan dengan tindakan kekerasan seksual Incest yang dilakukan oleh Ayah, kakak, dan adik yang dapat kepada korban yang merupakan anak berusia 18 tahun. Pada bagian ini akan dibahas mengenai analisis motif, dampak, sampai pada intervensi yang dapat dilakukan oleh profesi pekerjaan sosial pada anak dan keluarga. AbstractViolence against children until now is rampant. Sexual violence on children is one of the acts of violence which is quite increasing. Based on various data, the perpetrators of violence came from the closest family owned by the victim. Cases of sexual violence that will be discussed at this time are related to acts of sexual violence incest committed by fathers and siblings who get to victims who are children aged 18 years. This section will discuss the analysis of motives, impacts, and the interventions that can be carried out by the profession of social work in children and families.
IMPLEMENTASI PROGRAM CORPORATE SOCIAL RESPONSIBILITY OLEH PERUSAHAAN UNICORN DI INDONESIA
Authors: Yusuf Yoga Maulana , Prastyo Dimas Aji , Khaerunnisa Levina , Raharjo Santoso Tri 
Published: February 2020

ABSTRAK Corporate Social Responsibility (CSR) adalah kegiatan perusahaan dalam mengelola bisnis perusahaan demi menghasilkan dampak positif bagi lingkungan masyarakat baik dalam bidang ekonomi, budaya, dan lingkungan. Hal ini karena perusahaan memiliki tanggung jawab terhadap efek yang dihasilkan oleh perusahaan. Seperti yang kita tahu, bahwa di Indonesia sendiri memiliki beberapa perusahaan besar yang dikategorikan sebagai Unicorn. Mayoritas dari perusahaan ini memanfaatkan teknologi komunikasi dalam prosesnya. Sehingga dampak yang dihasilkan jika dibandingkan dengan perusahaan yang memanfaatkan sumber daya alam, adalah sangat sedikit. Namun, keuntungan yang dihasilkan tidak kalah besar dibandingkan dengan perusahaan yang memanfaatkan sumber daya alam. Dilansir dari CNN Indonesia, bahwa keuntungan yang dihasilkan oleh salah satu perusahaan unicorn di Indonesia adalah sebesar Rp. 90,4 triliun per tahun. Namun apa saja kah implementasi CSR yang telah dilaksanakan? Terdapat tiga unicorn yang akan digunakan dalam penelitian ini yakni Tokopedia, Go-Jek, dan Bukalapak. Beberapa program yang akan dijelaskan yakni Nakamate oleh Tokopedia, Go-Scholar Tech oleh Go-Jek, BSC (Bukalapak Social Club) oleh Bukalapak. Penelitian ini dilaksanakan menggunakan pendekatan kualitatif dengan metode deskriptif sehingga peneliti ingin memberikan gambaran mengenai implementasi CSR pada perusahaan unicorn di Indonesia. ABSTRACT Corporate Social Responsibility is company bussiness managing activity in order gaining positive impact for the environment and also in society who live around the company in economic, culture, and environment side. The company has the responsibility to the effect that might affect the society around caused by the company itself. Indonesia h as so many huge companies called unicorn cause mostly those companies use communication technology in the process of work. So that, compared to the others company who only use the natural resources in the work process has a big differ impact among it. But the profit is just almost the same huge. Reported by CNN Indonesia, the profit generated by one of the unicorn company in Indonesia is IDR 90.4 T per year. There are three unicorn companies that will be discussed in this research, namely Tokopedia, Gojek, and Bukalapak. Some programs that will be discussed are Nakamate by Tokopedia, Go - Scholar Tech by Gojek, BSC (Bukaalapak Social Club) by Bukalapak. This research uses qualitative approach with description method so that this research will give the descript ion about the implementation of CSR programs in Indonesian Unicorn Companies.