bluuebunny/crossref_metadata_2025_split huggingface dataset:
The forensic value of smile photograph and medical radiograph analysis in identifying human skeletonized remains: a case report
Authors: Ghazi Aljaber Abo Fakher Majid , Al-assaf Maher , Mimas Sharif , Aljaber Abo Fakher Mourad , Abdul-hak Mahmoud , Nofal Houssein 
Published: September 2020

AbstractBackgroundIdentifying human remains which are skeletonized, carbonized, disfigured, or fragmentized is a common task for forensic anthropologists and odontologists.Case presentationA case of unknown skeletonized remains is reported in this investigation, which was found in a mass grave in Damascus Countryside governorate, Syria, in 2017. The post-mortem (PM) examination of bones and teeth was completed in al-Muwasat University Hospital in Damascus. Skull and pelvic bones showed Caucasoid male traits: the fourth rib and teeth examination estimated the age to be between 30 and 40 years, and the long bone estimated the stature in centimeters to be between 172 and 179. Intact dentition with tiny fracture in the incisal edge of the upper right central incisor—along with pathological fracture of right patella—was noted. Matching with ante-mortem (AM) smile photograph and radiograph of the right knee led to positive identification.ConclusionsThe present study highlights the importance of maintaining and storage of medical radiographs or any other records that show the teeth or bones of the person.
Endovascular management of recurrent hemarthrosis of the knee: a case series
Authors: Pow Richard , Fritsch Brett , Waugh Richard , Rogan Chris 
Published: August 2020

Abstract
Background
Recurrent hemarthrosis of the knee is an uncommon but potentially debilitating occurrence with multiple etiologies, including previous total knee replacement. The purpose of this study is to present data of a group of patients undergoing angiography and embolization for recurrent hemarthrosis of the knee. Patient characteristics, angiographic findings, safety and efficacy of the procedure are reported.

Methods
A retrospective single centre review of patients undergoing angiography and embolization at a tertiary referral centre in Sydney, Australia from March 2006 to April 2018 was performed. A total of 25 patients undergoing a total of 29 procedures were identified (20 female, 5 male; mean age 67), the majority of which (23/25, 92%) had a history of total knee arthroplasty. Embolization was performed in 28 of the 29 procedures (97%). The embolic agent used was either polyvinyl alcohol particles (23/28), gelatin foam (3/28), detachable microcoils (1/28) or a combination of particles and coils (1/28).

Results
The most commonly identified dominant vascular abnormality was periarticular synovial hypervascularity (23/25, 92%). A pseudoaneurysm was demonstrated in two patients (8%). Technical success (elimination of angiographic abnormalities) was achieved in 27 of 29 procedures (93%). There were 6 episodes of recurrence (25%) following a single embolization procedure, three of which were managed successfully with repeat embolization. There were no complications relating to skin or periarticular ischemia.

Conclusion
Angiography and embolization is a safe and effective tool for the management of recurrent hemarthrosis of the knee following arthroplasty and should be considered first line treatment following failure of conservative management.

Level of evidence
Level 4, Case Series.
Home food making, belonging, and identity negotiation in Belgian Taiwanese immigrant women’s everyday food practices
Authors: Lin Hsien-Ming , Pang Ching Lin , Liao Da-Chi 
Published: September 2020

AbstractThis article examines the experiences of (re)producing home food in the daily life and food practices of Belgian Taiwanese immigrant women. The research is based on ethnography—both online and offline—and qualitative semi-structured interviews with seventeen Taiwanese immigrant women/housewives in Belgium. Participants’ food practices involve buying, growing, making, and sharing food. Buying Taiwanese food ingredients presents a genuine challenge, as Chinese and Asian supermarkets in Belgium do not carry all Taiwanese food items. Consequently, many Taiwanese immigrant women and housewives in this study share similar experiences of growing specific foods in their home garden; moreover, by doing so, they also transform their gardens in their private homes into transnational social spaces, and thereby connect their previous lived experiences and homeland memories with their present living circumstances. Moreover, Taiwanese immigrant women like to prepare and cook food with their husband and children while imparting Taiwanese food and cultural values through personal stories. Furthermore, by organizing and regularly participating in activities involving sharing and eating food with other Taiwanese immigrant women, these food-sharing events and behaviors also become an important social networking strategy that allows them to make, expand, and cultivate friendships; in addition, food sharing activities also assist the participants to construct a collective social identity of being immigrant mothers/housewives in a foreign land. However, what is meant by “Taiwanese” food varies substantially between participants, as do the associated emotional and ethnic meanings. Several things were stated to account for the taste of Taiwanese food, such as using certain condiments or the Ta Tung rice cooker. Equally diverse is the personal attachment of ethnonational identity toward the notion of home food, as discussions of childhood memories, ethnonational identity negotiation, and cultural markers are accompanied by critical reflection on the social constructed nature of home/ethnic foods in the migration contexts.
Characteristics of natural biopolymers and their derivative as sorbents for chromium adsorption: a review
Authors: Zhang Ruoshi , Tian Yongqiang 
Published: August 2020

Abstract
Chromium is widely used in industry, and improper disposal of wastewater and industrial residues containing excessive chromium can contaminate water and soil, endangering both environmental and human health. Natural biopolymers and their derivatives have been investigated for removal of chromium (Cr) from wastewater. Cellulose, lignin, tannin, chitin, chitosan, and polypeptides are abundant in nature, and have high potential as adsorbents due to their easy access, low cost, and the recyclability of the captured heavy metals. In order to improve their mechanical strength, recyclability, specific surface area, binding site number, and adsorption rate as adsorbents, native materials have also been modified. This review discusses the source of chromium contamination and the main species of interest, as well as their toxicity. The structures of the aforementioned biopolymers were analyzed, and the adsorption mechanism of chromium and the main influencing factors on this process are discussed. The modification methods of various adsorbents and their adsorption effects on chromium are also detailed, and the developmental direction of research on the use of biopolymer adsorption remediation to control chromium contamination is discussed.

Graphical abstract
Resurfacing hemiarthroplasty versus stemmed hemiarthroplasty for glenohumeral osteoarthritis: a meta-analysis
Authors: Zhang Baoliang , Chen Guanghui , Fan Tianqi , Chen Zhongqiang 
Published: September 2020

Abstract
Background
Though total shoulder arthroplasty (TSA) has been an acknowledged treatment option for glenohumeral osteoarthritis, resurfacing hemiarthroplasty (RHA) and stemmed hemiarthroplasty (SHA) may be preferred in some circumstances by surgeons, especially for treating young or active patients. However, decision-making between the RHA and SHA is controversial. Therefore, we conducted a meta-analysis to systematically compare two surgical procedures in terms of postoperative functional outcomes, range of motion (ROM), pain relief, complication rates, risk of revision.

Methods
The PubMed, Embase, Web of Science and Cochrane Library were searched from inception to January 1, 2020, for all articles that compared the clinical effectiveness and safety of RHA with SHA. All eligible studies were selected based on certain screening criteria. Two investigators independently conducted the quality assessment and extracted the data. Fixed-effect and random-effect models were used for pooled results according to the degree of heterogeneity. All statistical analyses were performed by employing Stata software 14.0.

Results
A total of six comparative studies involving 2568 shoulders (1356 RHA and 1212 SHA) were included in the final analysis. Patients were followed up for at least 1 year in each study. Pooled results showed that RHA was associated with a better visual analog scale (SMD 0.61, p = 0.001) but higher revision rates (OR 1.50, p = 0.016) when compared to SHA. There were no significant differences in functional outcomes, such as Constant-Murley score (SMD 0.06, P = 0.878), American Shoulder and Elbow Surgeons score (SMD 0.05, P = 0.880), Western Ontario Osteoarthritis of the Shoulder index (SMD 0.43, p = 0.258) and quick-Disabilities of the Arm, Shoulder and Hand score (SMD 0.06, p = 0.669). In addition, no differences were observed in forward flexion (SMD 0.16, p = 0.622), external rotation (SMD -0.17, P = 0.741) and overall complication rates (OR 1.42, p = 0.198).

Conclusion
This is the first meta-analysis to investigate the clinical efficacy and safety of RHA in comparison with SHA for the treatment of glenohumeral osteoarthritis. The results demonstrated that the two surgical techniques were equivalent in terms of postoperative functional outcomes and complication rate. However, RHA provided greater pain relief but posed a higher risk for revision than SHA. More high-quality studies with long-term follow up are warranted to give more convincing evidence.
Myocardial viability imaging using a novel non-breath-hold cardiac MRI protocol: a comparative assessment with 18F-FDG PET
Authors: Aggarwal Rohit , Singla Geetika , Singh Harkirat , George Raju Augustine , Mukhopadhyay Indrani 
Published: September 2020

Abstract
Background
Delayed contrast enhancement on cardiac magnetic resonance imaging is a well-established MRI technique for the evaluation of myocardial tissue viability. A comprehensive cardiac MRI protocol for myocardial viability comprises of multiple breath hold sequences to provide information regarding chamber volumes, myocardial mass, and function in addition to viability. However, its routine use is limited mainly by lengthy acquisition time and patient’s inability to hold breath in multiple breath hold sequences. The important question to which the referring cardiologists/cardiac surgeons are seeking answer is that “What are the viable vascular territories that will benefit from revascularization?” In this study, we have analyzed the utility of non-breath-hold rapid delayed contrast-enhanced cardiac MR imaging protocol for myocardial viability assessment with 18-flourodeoxyglucose positron emission tomography (18F-FDG PET) as the reference standard.

Results
Forty patients of ischemic heart disease who met the inclusion criteria were included. All patients underwent both 18F-FDG PET and delayed contrast-enhanced cardiac magnetic resonance imaging as per the non-breath-hold protocol. In this free-breathing protocol, the breath hold cine sequences were omitted and, after localizers, post-contrast scans were obtained with a time gap of 15 min post-contrast administration. A total number of 680 myocardial segments and corresponding 120 vascular territories were assessed. MRI and 18F-FDG PET images were analyzed using a 17-segment model as proposed by AHA. Sensitivity, specificity, positive predictive value, and negative predictive value of non-breath-hold rapid delayed contrast-enhanced cardiac MR imaging protocol for assessing myocardial viability (on segment analysis) was 95.5%, 65.59%, 88.0%, and 84.72%, respectively, and of vascular territory analysis were 96.77%, 92.59%, 97.83%, and 89.29%, respectively, in relation to 18F-FDG PET used as the reference standard. Spearman’s rank correlation coefficient is 0.62.

Conclusion
This modified non-breath-hold delayed contrast-enhanced cardiac MR imaging protocol is a reliable tool to answer the clinically relevant question of myocardial viability with a significant reduction in acquisition time and overcomes the limiting need of breath hold.
Short-term outcomes of surgical myocardial revascularization on health-related quality of life: a validation of the Arabic MacNew heart disease questionnaire
Authors: Abdallah Mohammad , Mamdouh Shymaa , El-Gilany Abdel-Hady , Abdel-Aziz Wael , Farag Olfat , ElAdawy Noha 
Published: September 2020

AbstractBackgroundImpaired quality of life (QOL) is common in coronary heart disease and is the major indications for coronary artery bypass graft (CABG) operations. This study aims to compare the QOL of patients with coronary heart disease before and after CABG surgery.ResultsA translated Arabic version of the Mac-New health-related QOL questionnaire was used to evaluate QOL improvement in 446 patients who benefited from elective CABG at Nasser Institute for Research and Treatment. There was a statistically significant improvement in physical, emotional, social, and global domains of QOL, as evaluated 3 and 6 months after surgery. Follow-up was 90.4% complete. At 3 months, multiple linear regression has shown that male patients (β= 0.48,p≤ 0.001) and rural residence (β= 0.39,p≤ 0.001) were significant independent predictors of improvement in physical QOL domain. While hypercholesterolemia (β= −0.20, −0.49, −0.37, −0.46,p≤ 0.001), hypertension (β= −0.29, −0.39,p≤ 0.001,β= −0.35, −β= 0.35,p= 0.001), and smoking (β = −0.79,p≤ 0.001,β= −0.33,p= 0.04,β= −0.69,p≤ 0.001,β= −0.47,p= 0.005) were significant predictors of worsening in physical, emotional, social, and global domains, respectively. At 6 months, low preoperative ejection fraction (EF) ≤ 40% was the strongest predictor of improvement (β= 0.54, 0.49, 0.44, and 0.52,p≤ 0.001) in physical, emotional, social, and global domains of QOL, respectively. But, peripheral vascular disease (PVD) (β = −0.53,p= 0.05,β= −0.81,p= 0.005,β= −0.62,p= 0.03,β= −0.76,p= 0.008) and smoking (β= −0.53,p= 0.001,β= −0.42,p= 0.01,β= −0.42,p= 0.01,β= −0.41,p= 0.02) were significant predictors of worsening in physical, emotional, social, and global domains of QOL, respectively.ConclusionsCABG surgery improved in all domains of QOL. Further studies are required to evaluate changes in QOL at longer period intervals.
Gene XRCC1Arg399Gln polymorphism and its genotype variations: clinical associations in Egyptian systemic lupus erythematosus patients
Authors: Mortada Mohamed A. , Zidan Haidy E. , Abdelsalam Noha A. , Eltoukhy Mirvat A. 
Published: September 2020

Abstract
Background
Impaired deoxyribonucleic acid (DNA) repair may induce an autoimmune response in susceptible individuals. The association between DNA repair gene XRCC1 Arg399Gln gene polymorphism and susceptibility of systemic lupus erythematosus (SLE) is controversial. This study aimed to detect the association of XRCC1 Arg399Gln gene polymorphism with SLE and its clinical manifestations in the Egyptian population.

Results
A significant association was found between weight loss and genotype GG (P = 0.048); however, genotype AG was significantly associated with high serum creatinine and low C3 level (P = 0.039, P = 0.009, respectively). On the other hand, there was no significant difference between patients and controls regarding genotype and allele frequency.

Conclusions
An association was found between weight loss, high serum creatinine, and low C3 level and genotypes of XRCC1 Arg 399 Gln gene polymorphism.
Inter-compound and Intra-compound Global Sensitivity Analysis of a Physiological Model for Pulmonary Absorption of Inhaled Compounds
Authors: Melillo Nicola , Grandoni Silvia , Cesari Nicola , Brogin Giandomenico , Puccini Paola , Magni Paolo 
Published: August 2020

AbstractIn recent years, global sensitivity analysis (GSA) has gained interest in physiologically based pharmacokinetics (PBPK) modelling and simulation from pharmaceutical industry, regulatory authorities, and academia. With the case study of an in-house PBPK model for inhaled compounds in rats, the aim of this work is to show how GSA can contribute in PBPK model development and daily use. We identified two types of GSA that differ in the aims and, thus, in the parameter variability: inter-compound and intra-compound GSA. The inter-compound GSA aims to understand which are the parameters that mostly influence the variability of the metrics of interest in the whole space of the drugs’ properties, and thus, it is useful during the model development. On the other hand, the intra-compound GSA aims to highlight how much the uncertainty associated with the parameters of a given drug impacts the uncertainty in the model prediction and so, it is useful during routine PBPK use. In this work, inter-compound GSA highlighted that dissolution- and formulation-related parameters were mostly important for the prediction of the fraction absorbed, while the permeability is the most important parameter for lung AUC and MRT. Intra-compound GSA highlighted that, for all the considered compounds, the permeability was one of the most important parameters for lung AUC, MRT and plasma MRT, while the extraction ratio and the dose for the plasma AUC. GSA is a crucial instrument for the quality assessment of model-based inference; for this reason, we suggest its use during both PBPK model development and use.
Role of a regulatory and governance framework in human biological materials and data sharing in National Biobanks: Case studies from Biobank Integrating Platform, Taiwan and the National Biorepository, Uganda
Authors: Nansumba Hellen , Ssewanyana Isaac , Tai Micheal , Wassenaar Douglas 
Published: September 2020

Background: In the last decade, Low- and Middle-Income Countries (LMICs) have set up Biobanks to collect human biological materials and associated data for genomic research and public health purposes. Biobanking gives rise to ethical challenges, such as informed consent, benefit sharing, confidentiality, ownership, commercialization and public participation which are harder to navigate in LMIC settings due to disparities in research infrastructure and capacity. This paper summarizes presentations on Biobank related case studies from two countries, with a focus on challenges in the regulatory and governance framework and suggestions on how to mitigate them. Methods: Two case studies of Biobanks from LMICs have been used. The case studies were presented at the 2018 Global Forum on Bioethics in Research (GFBR) meeting on the “Ethics of data sharing and Biobanking in health research”. Results: The case studies show that an integrated, well-regulated platform for human biological materials and data ensures good quality of human biological materials, saves resources and promotes mutual collaboration of work among researchers. National regulatory bodies are required to generate Biobanking guidelines and policies to facilitate guidance to the rapidly changing landscape of science. Discussion: In general, LMICs have weaker research regulatory infrastructure and governance mechanisms for Biobanks than high-income countries. This has increased the fear of exploitation i.e. unfair distribution of risks and benefits. Establishment of Biobanks and producing effective scientific outcomes based on the Biobanking resources is difficult without a proper legislative, regulatory and governance framework. Conclusion: These two case studies from different LMICs settings show that although in both settings there is strong awareness of the scientific and population health value of Biobanks and strong commitment to their establishment, regulatory and ethical guidance show gaps that need to be addressed.
Influence of task-oriented circuit training on upper limb function among rural community-dwelling survivors of stroke
Authors: Deshpande Shruti , Mohapatra Sidhiparada , Girish N 
Published: September 2020

Background Task-oriented circuit training using a Multi-Activities workstation emphasises goal-oriented tasks practiced in a circuit or series in order to learn a new skill. It can be used for upper limb rehabilitation among stroke patients in a community setting, but there is currently very little evidence available regarding its use in this patient group and setting. This study aimed to explore the influence of task-oriented circuit training using a Multi-Activities workstation on upper limb function among community-dwelling individuals with chronic stroke. Methods A pre-test–post-test study was conducted involving 17 community-dwelling individuals with chronic stroke who were attending a stroke rehabilitation centre. Six weeks of task-oriented circuit training was given using a Multi-Activities workstation aimed to improve strength, range of motion and dexterity. Streamlined Wolf Motor Function Test and Chedoke Arm and Hand Activity Inventory were used to measure outcomes. Wilcoxon signed-rank test was used for data analysis. Results A total of 12 sessions of task-oriented circuit training using Multi-Activities workstations did not result in any statistically significant differences in outcome measures. Conclusions Task-oriented circuit training using the Multi-Activities workstation did not improve upper limb function in community-dwelling individuals with chronic stroke.
Cement augmentation of calcar screws may provide the greatest reduction in predicted screw cut-out risk for proximal humerus plating based on validated parametric computational modelling
Authors: Varga Peter , Inzana Jason A. , Fletcher James W. A. , Hofmann-Fliri Ladina , Runer Armin , Südkamp Norbert P. , Windolf Markus 
Published: September 2020

Aims Fixation of osteoporotic proximal humerus fractures remains challenging even with state-of-the-art locking plates. Despite the demonstrated biomechanical benefit of screw tip augmentation with bone cement, the clinical findings have remained unclear, potentially as the optimal augmentation combinations are unknown. The aim of this study was to systematically evaluate the biomechanical benefits of the augmentation options in a humeral locking plate using finite element analysis (FEA). Methods A total of 64 cement augmentation configurations were analyzed using six screws of a locking plate to virtually fix unstable three-part fractures in 24 low-density proximal humerus models under three physiological loading cases (4,608 simulations). The biomechanical benefit of augmentation was evaluated through an established FEA methodology using the average peri-screw bone strain as a validated predictor of cyclic cut-out failure. Results The biomechanical benefit was already significant with a single cemented screw and increased with the number of augmented screws, but the configuration was highly influential. The best two-screw (mean 23%, SD 3% reduction) and the worst four-screw (mean 22%, SD 5%) combinations performed similarly. The largest benefits were achieved with augmenting screws purchasing into the calcar and having posteriorly located tips. Local bone mineral density was not directly related to the improvement. Conclusion The number and configuration of cemented screws strongly determined how augmentation can alleviate the predicted risk of cut-out failure. Screws purchasing in the calcar and posterior humeral head regions may be prioritized. Although requiring clinical corroborations, these findings may explain the controversial results of previous clinical studies not controlling the choices of screw augmentation.