bluuebunny/crossref_metadata_2025_split huggingface dataset:
OPTIMAL SEQUENCE OF APPLICATION OF EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITORS IN ADVANCED NON-SMALL CELL LUNG CANCER PATIENTS WITH ACTIVATING EGFR MUTATIONS
Authors: Kolomeytseva A. A. , Fedenko A. A. 
Published: December 2020

Background. Successful treatment of patients with EG FR-positive non-small cell lung cancer (NSCLC ) is directly related to epidermal growth factor receptor (EG FR) tyrosine kinase inhibitors (TKIs). Currently, three generations of EG FR TKIs are used for treatment of EG FR-positive NSCLC . The issue of what drug or what sequence of its administration will be the optimal treatment option for a particular patient seems relevant.Purpose: To analyze available data on the use of TKIs for the treatment of advanced EG FR-positive NSCLC patients, as well as to assess the possible mechanisms of resistance to them and determine the optimal sequence of EG FR TKI therapy.Material and Methods. The review includes data from randomized controlled trials, as well as data from real-world studies on the efficacy of EG FR TKIs and subsequent therapy options in cases of drug resistance.Results. The choice of the optimal first-line treatment option for patients with EG FR-positive NSCLC depends on many factors. To our opinion, afatinib therapy with subsequent osimertinib therapy allows maximal prolongation of low-toxic targeted therapy and delayed administration of cytostatic drugs in patients with T790M mutation.Conclusion. Considering the dominant mechanism of resistance development (presence of EG FR -T790M mutation), the use of the second- and third-generation EG FR inhibitors seems to be an optimal treatment option for patients with activating EG FR mutations.
DISSEMINATED GASTROINTESTINAL STROMAL TUMOR IN PREGNANCY. A CASE REPORT
Authors: Abdullaev A. G. , Kurbanov A. A. 
Published: December 2020

Background. Gastrointestinal stromal tumor (GIST ) is a rare neoplasm with an incidence of only 10–20 cases per million population. All gastrointestinal neoplasms may have malignant potential and most of them are sporadic tumors. GIST occurring during pregnancy is extremely rare, therefore, surgeons face challenging ethical, surgical and oncological issues. Case. We describe a clinical cause of GIST found at the 16–17-th week of pregnancy in a 31-year-old woman. The patient was under the supervision of obstetricians-gynecologists, radiologists and oncologists, and a weekly ultrasound examination was performed. Caesarean delivery was performed at the 26th week of pregnancy due to disease progression and in order to start anticancer therapy as soon as possible. Conclusion. We described the first reported case of a successful treatment in a 31-yearold pregnant patient with GIST of the small intestine complicated by peritoneal carcinomatosis and ascites. We compared our case with other reported cases of GIST during pregnancy and discussed the problems faced by both patients and surgeons. There are no recommendations on the optimal timing of tumor resection during pregnancy, and therefore key decisions must be made in a multidisciplinary team (MDT ), taking into account the wishes of the patient. Our clinical case demonstrates the feasibility of changing the approaches to the management and treatment of patients with intraperitoneal dissemination, as well as emphasizes the importance of interdisciplinary team including oncologists, obstetricians, gynecologists, neonatologists and other specialists.
CANCER INCIDENCE AND MORTALITY IN CHILDREN AND ADOLESCENTS IN PRIMORSKY KRAI FOR THE 2008–2018 PERIOD
Authors: Minkina L. M. , Tsvetkov M. M. , Tikhonova Ya. S. , Postoykina M. A. 
Published: December 2020

Background.Cancer is a leading cause of death in children and adolescents worldwide. The cancer incidence rate in children and adolescents has been on the rise for decades. Climatic, geographic and social factors of the region play an important role for cancer incidence.Objective:to analyze the cancer incidence and mortality rates in children and adolescents of Prymorsky krai.Methods.Cancer incidence rates in Russia for 2008–2018 as well as cancer incidence among children treated at the regional pediatric hematology/oncology center (Vladivostok, Russia) for 2014–2019 were analyzed.Results.No statistically significant differences in the cancer incidence rates for the 2008–2018 period between children and adolescents of Primorsky krai and the russian federation in the whole and the far-eastern federal district were found. In in Primorsky krai, there was a variability in the incidence rate during the analyzed period, a negative average annual growth rate in the group of children under 14 years of age (-0.86 %). For the 2008–2018 period, the cancer mortality rate in children and adolescents of Primorsky krai significantly decreased (from 5.65 ‰ in 2008 to 2.6 ‰ in 2018), with the average annual increase rate in children aged 017 years of -9.17 %. In 2014–2019, the quality of cancer detection improved significantly, and the number of children and adolescents with stage iiiiv cancer reduced.Conclusion.Cancer prevention and early detection can potentially reduce the cancer incidence and mortality rates in children and adolescents in Primorsky krai. Population-based cancer registries are needed for quantifying the burden of cancer in children and adolescents and assessing prevention and control programs.
STUDY OF CHANGES IN TUMOR BLOOD FLOW FOR THE ASSESSMENT OF EARLY RESPONSE TO NEOADJUVANT CHEMOTHERAPY IN BREAST CANCER PATIENTS
Authors: Pavlov M. V. , Rykhtik P. I. , Ilyinskaya O. E. , Subochev P. V. , Kreinina Yu. M. , Maslennikova A. V. 
Published: December 2020

Background. Over the past 20 years, there has been a change in approaches to the treatment of breast cancer, in particular, a significant increase in the role of drug therapy. Breast cancer response to neoadjuvant chemotherapy is currently considered as a surrogate biomarker, which allows evaluation of the clinical course and prognosis of the disease. To solve this problem, it is necessary to assess the functional and metabolic changes in tumor tissue during treatment. Doppler ultrasound is a non-invasive, affordable, and low-cost imaging technique that can be safely used for repeated measurements.The purpose of the study was to study vascular changes in the tumor by power Doppler ultrasound for the evaluation of the early breast cancer response to neoadjuvant chemotherapy.Material and Methods. From May 2017 to August 2019, 63 patients with breast cancer received neoadjuvant chemotherapy. Changes in the tumor blood flow were assessed before starting the treatment and prior to the second course of neoadjuvant chemotherapy using Doppler scanning. Changes in tumor blood floor after chemotherapy were compared with the pathological tumor response after surgical treatment.Results. In the vast majority of cases (78 %), there was a decrease in the number of tumor vessels after the first cycle of neoadjuvant chemotherapy independent of the grade of pathological response. In 8 cases with increased vascularization after the first cycle of neoadjuvant chemotherapy, histological examination of the removed tumor showed no response / weak response to treatment in the absence of peritumoral inflammation. In 5 cases, a sharp increase in the number of vessels around large areas of intranodular necrosis and peritumoral inflammation was observed. In general, a comparison of changes in tumor vascularization and pathological response revealed a weak, although statistically significant, negative correlation between changes in the tumor blood flow after neoadjuvant chemotherapy and pathological response.Conclusion. It was not possible to establish an unambiguous relationship between the reaction of the vascular bed and the tumor response to the cytostatic effect. An increase in the number of tumor vessels in the absence of peritumoral inflammation was the only situation when changes in tumor blood flow during chemotherapy can be unambiguously interpreted as a predictive criterion for the absence / weak response of the tumor to treatment.
Photolysis of sodium chloride and sodium hypochlorite by ultraviolet light inactivates the trophozoites and cysts of Acanthamoeba castellanii in the water matrix
Authors: Chaúque Beni J. M. , Rott Marilise B. 
Published: December 2020

Abstract
The present study aimed to investigate an effective, sustainable and accessible way to inactivate chlorine-resistant microorganisms, such as Acanthamoeba castellanii, through the photolysis of sodium chloride (NaCl) and sodium hypochlorite (NaOCl) in the water matrix. The trophozoites and cysts (2 × 107 per 8 mL) were exposed for 30, 60, 90, 120 and 150 min to the photolysis effect of NaOCl (1.0, 2.0, 4.0 and 8.0 mg/L) or NaCl (5.0, 10, 20 and 40 g/L) by ultraviolet light C (243 μW·cm2), then the viability was analyzed. The inactivation of all trophozoites was achieved by exposure to the photolysis effect of 2.0 mg/L of NaOCl or 20 g/L of NaCl, in 150 or 120 min, respectively. Inactivation of all cysts was achieved by double exposure to the photolysis effect of 1.0 mg/L NaOCl or 5.0 g/L NaCl from 90 min of each exposure round. The exposure time was a strong determinant in the inactivation of A. castellanii trophozoites or cysts. The photolysis of NaOCl or NaCl is an effective method to eliminate A. castellanii in water. These findings expand the list of chlorine-resistant microorganisms that can be inactivated by NaOCl photolysis and show that NaCl photolysis is a new and promising method for treating swimming pool water and wastewater.
Assessment of sunflower water stress using infrared thermometry and computer vision analysis
Authors: Nouraki Atefeh , Akhavan Samira , Rezaei Yousef , Fuentes Sigfredo 
Published: December 2020

Abstract
The objectives of the current study were to implement affordable and non-invasive measurements of infrared thermometry, leaf relative water content (RWC), crop water stress index (CWSI), leaf area index (LAI) from computer vision analysis and seed yield of sunflowers. The experiment was designed as split-plot based on randomized complete blocks with three replications. Treatments were four different levels of deficit irrigation as the main plots and three fertilization treatments were applied as sub-plots. Results showed a significant effect (P ≤ 0.01) of water stress and fertilizer on CWSI during different stages of sunflower growth. Changes in fertilizer amount and type resulted in a change in lower (dTLL) and upper (dTUL) limits of canopy-air temperature difference. A combination of chemical fertilizer with biofertilizer could help to decrease CWSI. From computer vision analysis, the normalized difference red blue index (NDRBI) had a strong linear relationship with RWC and CWSI for sunflowers (R2 of 0.87 and 0.93, respectively) and the normalized difference green blue index (NDGBI) had a linear relationship with seed yield (R2 = 0.79). Therefore, analysis of digital RGB images and CWSI were efficient, non-destructive and low-cost methods to assess crop water status for sunflowers under different irrigation and fertilizer treatments.
Ks. Stanisław Kisiel, „Kościół wierzący w naukę Chrystusa. Materiały na katechezy dla młodzieży licealnej i dorosłych o tematyce światopoglądowej, dogmatycznej, eklezjologicznej i o sektach”, wyd. IV, Bonus Liber 2019, ss. 350.
Authors: Wiśniewski Sebastian 
Published: December 2020

Książka ks. S. Kisiela stanowi cenną pomoc dla duszpasterzy, liderów wspólnot i wszystkich, którym zależy na własnej formacji katolickiej. Przedstawiono w niej nauczanie Kościoła dotyczące prawd wiary zawartych w Credo. Każdy z tematów został rzetelnie opracowany i może stanowić konspekt katechez dla młodzieży i dorosłych. Książka zasługuje na uwagę i pozytywne przyjęcie.
On m-polar Diophantine Fuzzy N-soft Set with Applications
Authors: Liu Jia-Bao , Ali Shahbaz , Mahmood Muhammad Khalid , Mateen Muhammad Haris 
Published: December 2020

Introduction:
In this paper, we present a novel hybrid model m-polar Diophantine fuzzy N-soft set and define
operations on it.

Methods:
We generalize the concepts of fuzzy sets, soft sets, N-soft sets, fuzzy soft sets, intuitionistic fuzzy sets,
intuitionistic fuzzy soft sets, Pythagorean fuzzy sets, Pythagorean fuzzy soft sets and Pythagorean fuzzy N-soft sets by
incorporating our proposed model. Additionally, we define three different sorts of complements for Pythagorean fuzzy Nsoft sets and examine few outcomes which do not hold in Pythagorean fuzzy N-soft sets complements unlike to crisp set.
We further discuss about (α, β, γ) -cut of m-polar Diophantine fuzzy N-soft sets and their properties. Lastly, we prove our
claim that the defined model is a generalization of soft set, N-soft set, fuzzy N-soft set, intuitionistic fuzzy N soft set and
Pythagorean fuzzy N-soft set.

Results:
m-polar Diophantine fuzzy N-soft set is more efficient and an adaptable model to manage uncertainties as it also
overcome drawbacks of existing models which are to be generalized.

Conclusion:
We introduced novel concept of m-polar Diophantine fuzzy N-soft sets (MPDFNS sets).
O CONTROLE ILIMITADO DAS EMPRESAS-PLATAFORMA NA SOCIEDADE DA VIGILÂNCIA E OS IMPACTOS NAS GREVES
Authors: Barbato Maria Rosaria , Moura Natália das Chagas 
Published: December 2020

Com o avanço e o desenvolvimento da tecnologia, os empregadores tem utilizado dispositivos tecnológicos que potencializam o poder diretivo e de controle sobre os trabalhadores. Por outro lado, o emprego dessas tecnologias está limitado a algumas garantias e direitos fundamentais do ser humano, como o direito à privacidade, à intimidade, à liberdade de expressão, ao direito de reunião e está sujeito às obrigações contratuais de transparência e de lealdade. Este ensaio objetiva, por meio de estudos de algumas greves e manifestações que vêm ocorrendo em face de empresas-plataformas, refletir sobre o controle ilimitado que está sendo implantado em relação ao trabalho uberizado. Pretende também observar como esse controle está sendo viabilizado pela própria adesão dos trabalhadores à lógica empresarial. Elege-se, como metodologia, a análise bibliográfica e de dados, assim como o estudo de algumas entrevistas que revelam a dimensão desse controle sobre o trabalho humano.
CiTAR - Preserving Software-based Research
Authors: Rechert Klaus , Stobbe Oleg , Zharkow Oleg , Gieschke Rafael , Wehrle Dennis 
Published: December 2020

In contrast to books or published articles, pure digital output of research projects is more fragile and, thus, more difficult to preserve and more difficult to be made available and to be reused by a wider research community. Not only does a fast-growing format diversity in research data sets require additional software preservation but also todayâ€™s computer assisted research disciplines increasingly devote significant resources into creating new digital resources and software-based methods.
In order to adapt FAIR data principles, especially to ensure re-usability of a wide variety of research outputs, novel ways for preservation of software and additional digital resources are required as well as their integration into existing research data management strategies.
This article addresses preservation challenges and preservation options of containers and virtual machines to encapsulate software-based research methods as portable and preservable software-based research resources, provides a preservation plan as well as an implementation.
About the Influence of Optical Distortions in the Research of Quick Flowing Dynamic Processes Using a High-Speed Video Camera
Authors: Pisarev S. A. , Chirkov D. V. , Fedorova E. A. 
Published: December 2020

Цифровая высокоскоростная видеосъемка является одним из наиболее современных технических средств при исследовании быстропротекающих динамических процессов. В области экспериментальной баллистики методы мгновенной фотографии и скоростной киносъемки используются достаточно давно и, как правило, являются инструментом для проведения качественных исследований. Цифровой формат фотографий позволяет использовать видеокамеру в совокупности с различными программами для обработки изображений в качестве измерительного комплекса, который с достаточной точностью определяет кинематические параметры, характеризующие движение исследуемого объекта. Несмотря на широкое применение скоростной видеосъемки для исследований быстропротекающих процессов, на сегодняшний день достаточно мало работ, связанных с исследованием погрешностей при проведении изменений с применением высокоскоростной видеосъемки.В статье представлен исторический очерк использования методов фотографирования в экспериментальной баллистике ствольного оружия и приведены результаты качественного анализа оптических погрешностей и искажений (аберраций), возникающих при формировании изображений камерой высокоскоростной видеосъемки. На основе исследований влияния аберраций, возникающих при формировании изображений камерой высокоскоростной видеосъемки OLYMPUS i-SPEED 3 с использованием объективов с различным фокусным расстоянием, разработаны рекомендации применения ее при проведении кинематического и динамического анализов различных процессов и явлений.В зависимости от скорости видеосъемки и применяемого объектива разработаны рекомендации по расположению объекта и области исследований поля объектива. Показано, что наряду с фокусным расстоянием объектива важным параметром является светосила, которая при высокой частоте видеосъемки должна быть не менее 1:1,5.
Media Pembelajaran berbasis Augmented Reality "PRIARMIKA"
Authors: Putra I Kadek Mahada , Astawa Ni Luh Putu Ning Septyarini Putri , Satwika I Putu 
Published: December 2020

Pada penelitian ini membahas tentang rancang bangun aplikasi Android dengan menggunakan teknologi augmented reality yang digunakan dalam mata pelajaran Bahasa Inggris di SMPN 5 Mengwi. Aplikasi yang diberi nama PRIARMIKA (Primakara Augmented Reality Endemic Application) menjelaskan tentang deskripsi hewan endemik yang ditampilkan dalam bentuk 3D. Metode yang digunakan dalam pembuatan aplikasi ini adalah MDLC (Multimedia Development Life Cycle) versi Luther – Sutopo yang terdiri dari enam tahap diantaranya: 1) Concept, 2) Design, 3) Meterial Collecting, 4) Assembly, 5) Testing, 6) Distribution. Aplikasi PRIARMIKA akan divalidasi oleh 3 ahli validator yaitu ahli media, ahli materi dan ahli bahasa. Pengujian aplikasi dilakukan pada kelas VIII SMPN 5 Mengwi sebanyak 28 siswa dan 1 guru Bahasa Inggris. Berdasarkan hasil penelitian, dapat disimpulkan bahwa rancang bangun aplikasi augmented reality PRIARMIKA berbasis Android layak untuk digunakan sebagai media pembelajaran Bahasa Inggris kelas VIII di SMPN 5 Mengwi.
Evaluasi Tingkat Kepuasan Pasien Terhadap Pelayanan Kefarmasian Di Rumah Sakit Sekarwangi Cibadak Kabupaten Sukabumi.
Authors: Muhammad Diki , Almasyhuri Almasyhuri , Setiani Lusi Agus 
Published: December 2020

Kepuasan pasien merupakan penilaian dari seseorang antara kinerja pelayanan yang dirasakan dan diharapkan. Apabila kinerja di bawah harapan maka pasien akan kecewa dan tidak puas, sebaliknya bila kinerja sesuai yang diharapkan pasien, maka pasien akan merasa puas. Pihak rumah sakit harus berhati-hati dalam memberikan pelayanan kesehatan, karena jika pasien sering merasa tidak puas terhadap pelayanan yang diberikan maka akan berdampak hilangnya pelanggan/pasien, serta tingkat kepuasan pasien sangat tergantung pada mutu pelayanan yang diberikan. Rancangan penelitian ini merupakan penelitian Observasional analitik (Non-Exsperimental) menggunakan pendekatan metode cross sectional. tehnik yang digunakan dalam pengambilan sampel adalah accidental sampling dengan jumlah responden 126 orang. dengan cara mewawancarai menggunakan kuisioner yang berisi berupa 15 pertanyaan yang sudah divalidasi. Kepuasan pelayanan kefarmasian diukur dengan mengunakan skala likert. Hasil penelitian tingkat kepuasan pasien pada dimensi tangible diperoleh skor 73,1%, realibility 71,3%, responsiveness 75,1%, assurance 72,3%, dan emphaty 80,3%. Secara keseluruhan didapatkan persentase skor rata-rata 74,4% maka dikategorikan pasien merasa puas terhadap pelayanan kefarmasian di RSUD Sekarwangi. Pada karakteristik pasien: umur, pekerjaan, kategori pasien (BPJS/Non-BPJS), dan pendidikan terakhir didapat nilai p-value <0.05 maka hal itu menunjukan adanya hubungan dengan tingkat kepuasan pasien, sedangkan pada karakteristik pasien jenis kelamin tidak terdapat hubungan dengan tingkat kepuasan pasien, karena nilai p-value >0.05.
Analisis Penyelesaian Sengketa Kewenangan Lembaga Negara Oleh Mahkamah Konstitusi
Authors: Kosariza Kosariza , Netty Netty , Yarni Meri 
Published: December 2020

Tujuan dari penelitian ini adalah untuk mengetahui dan menganalisis bentuk pengaturan penyelesaian sengketa kewenangan lembaga negara berdasarkan perundang-undangan dan mengetahui dan menganalisis bentuk objek sengketa kewenangan lembaga negara dan pengaturan yang ideal dalam penyelesaiannya oleh Mahkamah Konstitusi. Penelitian ini bersifat deskriptif analitis, yaitu berusaha memberikan gambaran atau uraian yang deskritif mengenai permasalahan. Dengan menggunakan metode pendekatan normatif, dan untuk melengkapi data, penulis menggunakan pendekatan empiris disamping bahan hukum primer, sekeunder sebagai sumber data utama dengan analisis data secara kualitatif, kemudian hasilnya dikumpulkan dan dianalisis relevansinya dan diambil kesimpulan. Hasil penelitian menunjukan bahwa pengaturan penyelesaian sengketa lembaga negara, sesuai dengan apa yang dinyatakan dalam Undang-Undang Dasar Negara Republik Indonesia Tahun 1945, kemudian pasal tentang objek peneelitian ini dilaksanakan oleh peraturan pelaksananya dalam bentuk Undang-undang yaitu Undang-Undang Nomor 24 Tahun 2003 yang diubah oleh Undang-Undang Nomor 8 Tahun 2011 tentang Mahkamah Konstitusi. UU ini dengan tegas menyatakan bahwa pengaturannya dimana Mahkamah Konstitusi diberikan kewenangan untuk mengatur hal-hal yang diperlukan bagi kelancaran pelaksanaan tugas dan wewenangnya. Sejak keberadaan lembaga Mahkamah Konstitusi sampai sekarang permohonan sengketa kewenangan lembaga negara yang diajukan ke Mahkamah Konstitusi. Dari hasil penelitian dapat disarankan bahwa sangat diperlukan kejelasan Pengaturan kedepan penyelesaian sengketa kewenangan antar lembaga Negara di Mahkamah Konstitusi, oleh karena itu penting untuk dilakukan penataan demi kelancaran tugas dan kewenangan Mahkamah Konstitusi sebagai lembaga peradilan tertinngg yang sifat putusannya final dan mengikat
Pengaruh Kepercayaan Dan Penerapan Teknologi Aplikasi Zakat Terhadap Minat Masyarakat Dalam Berzakat
Authors: Rahmani Hani Fitria , Erpurini Wala 
Published: December 2020

Saat ini penerapan teknologi penerimaan zakat berbasis aplikasi telah banyak berkembang di Indonesia namun kesadaran membayar zakat di kalangan masyarakat yang telah berpenghasilan yang seharusnya menjadi muzakki atau pemberi zakat masih belum berimbang dengan mustahik atau penerima zakat. Sedangkan, potensi zakat di Indonesia sangat besar menurut Sekretaris Jendral Kementrian Agama Nur Syam mencapai 217 Triliun pada tahun 2018 (Sumber: bisnis.com), sedangkan dana zakat yang terhimpun pada tahun 2018 sebesar Rp. 203 Miliar (Sumber: antaranews.com). Metode yang digunakan dalam penelitian ini adalah studi literatur, observasi, dan kuesioner. Kuesioner disebar dan data yang terkumpul 148 sampel dari populasi 3 wilayah besar di Indonesia yaitu Dki Jakarta dan Banten, Jawa Barat, serta Jawa Timur dengan metode penarikan sampel menggunakan metode Cluster Sampling. Uji analisis dalam penelitian ini dengan menggunakan path analysis. Secara parsial masing-masing varibel memiliki hubungan dan pengaruh, namun dalam penelitian ini variabel penerapan teknologi berpengaruh paling besar terhadap minat masyarakat dalam berzakat, hal ini sejalan dengan penelitian yang di lakukan oleh Winda, et al (2018) yang menyatakan, secara konseptual peran teknologi internet dalam pengumpulan dana zakat dari muzakki, akan memperluas daya jangkau amil dalam mengakses muzakki, begitu juga sebaliknya dengan teknologi internet muzakki akan lebih mudah menyalurkan zakatnya kepada amil.