bluuebunny/crossref_metadata_2025_split huggingface dataset:
The value of CT imaging and CRP quotient for detection of postbariatric complications
Authors: Duprée Anna , de Heer Jocelyn , Tichby Michel , Ghadban Tarik , Mann Oliver , Grupp K. , Pinnschmidt Hans O. , Izbicki Jakob R. , Wolter Stefan 
Published: September 2020

Abstract
Background
The diagnosis of major complications seems to be more challenging in obese patients. We aimed to show the relevance of routinely assessed clinical and paraclinical parameters as well as the relevance of CT scans in the diagnosis of major complications after bariatric procedures.

Methods
All patients who underwent operations (primary or revisional) in a 3-year period were retrospectively studied after bariatric surgery with a specific focus on the routinely assessed clinical parameters (tachycardia, temperature), paraclinical parameters on postoperative day (POD) 1 and 3 (C-reactive protein (CRP), leukocytes), and additional computed tomography (CT) scan results for the diagnosis of leakage, bleeding, intraabdominal abscess, superficial abscess, and other complications.

Results
A total of 587 patients were examined. In this cohort, 73 CT scans were performed due to suspected intraabdominal or pulmonary complication according to our hospital standard operating procedure. In total, 14 patients (2.4%) had a major complication (Clavien-Dindo grade IV/V). Of those, 10 patients (1.7%) had postoperative leakage. While the correct leakage diagnosis was only found in 33% of the patients by CT scan, the overall specificity of CT as a diagnostic tool for all kinds of complications remained high. Especially for abscess detection, CT scan showed a sensitivity and specificity of 100%. Multivariate analysis showed a significantly higher risk of leakage development characterized by a doubling of postoperative CRP level (odds ratio 4.84 (95% confidence interval 2.01–11.66, p < 0.001)). To simplify the use of CRP as a predictive factor for the diagnosis of leakage, a cut-off value of 2.4 was determined for the CRP quotient (POD3/POD1) with a sensitivity of 0.88 and a specificity of 0.89.

Conclusion
CT diagnostic after bariatric surgery has a high positive predictive value, especially for intraabdominal abscess formation. Nevertheless, CT scan for the diagnosis of leakage has a low sensitivity. Thus, a negative CT scan does not exclude the presence of a leakage. Using the described CRP quotient with a cut-off of 2.4, the risk of early leakage can be easily estimated. Furthermore, in any uncertain case of clinically suspected leakage, diagnostic laparoscopy should be performed.
The effect of climate change on laying dates, clutch size and productivity of Eurasian Coots Fulica atra
Authors: Halupka Lucyna , Czyż Beata , Macias Dominguez Carlos Moises 
Published: September 2020

AbstractClimate change is affecting many living organisms; however, the responses of many of them remain unknown. In this paper, we present the results regarding the response of a bird species from the rallid family to the increased temperatures during the breeding season. We analysed the breeding data of Eurasian Coots nesting during 30 seasons between 1972 and 2019. During the study period, mean temperatures in April, the month when Coots start nesting, increased by 3.5 °C, and in months corresponding with the species breeding season by 2.6 °C. Breeding Coots advanced their earliest and median laying dates across the study period; however, the duration of their breeding season remained unchanged. We did not detect any significant temporal changes in clutch size, but clutches have become much more variable in size throughout the study period. Nest failures and production of offspring per nest did not change over the study period; however, the production of young per successful nest significantly declined. It is likely that this decline is the effect of mismatch between the period of food abundance (dipterans collected from water), and hatchling emergence, which is advanced due to change in climate. Future studies investigating the occurrence of dipteran resources at water bodies are needed to test this hypothesis.
Efficacy and safety of lipegfilgrastim versus pegfilgrastim in elderly patients with aggressive B cell non-Hodgkin lymphoma (B-NHL): results of the randomized, open-label, non-inferiority AVOID neutropenia study
Authors: Link Hartmut , Illerhaus G. , Martens U. M. , Salar A. , Depenbusch R. , Köhler A. , Engelhardt M. , Mahlmann S. , Zaiss M. , Lammerich A. , Bias P. , Buchner A. 
Published: September 2020

Abstract

Background
Lipegfilgrastim has been shown to be non-inferior to pegfilgrastim for reduction of the duration of severe neutropenia (DSN) in breast cancer patients. This open-label, non-inferiority study assessed the efficacy and safety of lipegfilgrastim versus pegfilgrastim in elderly patients with aggressive B cell non-Hodgkin lymphoma (NHL) at high risk for chemotherapy-induced neutropenia.

Patient and methods
One hundred and one patients (median age, 75 years) were randomized to lipegfilgrastim or pegfilgrastim (6 mg/cycle) during six cycles of R-CHOP21.

Results
Lipegfilgrastim was non-inferior to pegfilgrastim for the primary efficacy endpoint, reduction of DSN in cycle 1. In the per-protocol population, mean (standard deviation) DSN was 0.8 (0.92) and 0.9 (1.11) days in the two groups, respectively; the adjusted mean difference between groups was − 0.3 days (95% confidence interval, − 0.70 to 0.19). Non-inferiority was also demonstrated in the intent-to-treat population. The incidence of severe neutropenia in cycle 1 was 51% (21/41) in the lipegfilgrastim group and 52% (23/44) in the pegfilgrastim group. Very severe neutropenia (ANC < 0.1 × 109/L) in cycle 1 was reported by 5 (12%) patients in the lipegfilgrastim group and 8 (18%) patients in the pegfilgrastim group. However, over all cycles, febrile neutropenia (strict definition) was reported by only 1 (2%) patient in each treatment group (during cycle 1 in the lipegfilgrastim group and cycle 6 in the pegfilgrastim group). The mean time to absolute neutrophil count recovery (defined as ≥ 2.0 × 109/L) was 8.3 and 9.4 days in the two groups, respectively. Serious adverse events occurred in 46% of patients in each group; none were considered treatment-related. Eight patients died during the study (2 in the lipegfilgrastim group, 5 in the pegfilgrastim group, and 1 who died before starting study treatment). No deaths occurred during the treatment period, and all were considered to be related to the underlying disease.

Conclusions
This study shows lipegfilgrastim to be non-inferior to pegfilgrastim for the reduction of DSN in elderly patients with aggressive B cell NHL receiving myelosuppressive chemotherapy, with a comparable safety profile.

Trial registration number
ClinicalTrials.gov identifier NCT02044276; EudraCT number 2013-001284-23
Existence results for double phase implicit obstacle problems involving multivalued operators
Authors: Zeng Shengda , Bai Yunru , Gasiński Leszek , Winkert Patrick 
Published: September 2020

AbstractIn this paper we study implicit obstacle problems driven by a nonhomogenous differential operator, called double phase operator, and a multivalued term which is described by Clarke’s generalized gradient. Based on a surjectivity theorem for multivalued mappings, Kluge’s fixed point principle and tools from nonsmooth analysis, we prove the existence of at least one solution.
Bacterial strains colonizing the sensor electrodes of a continuous glucose monitoring system in children with diabetes
Authors: Seget Sebastian , Rusak Ewa , Partyka Mirosław , Samulska Ewa , Pyziak-Skupień Aleksandra , Kamińska Halla , Skała-Zamorowska Eliza , Jarosz-Chobot Przemysława 
Published: September 2020

Abstract
Introduction
The higher frequency of infections in diabetic patients is caused by a hyperglycemic environment, which promotes immune dysfunction. People with diabetes are more prone to skin infections.
A continuous glucose monitoring (CGM) system provides information on changes in blood glucose (BG) levels throughout the day. Its use facilitates optimal therapeutic decisions for a diabetic patient. One of the factors limiting the use of CGM is inflammation at the insertion site.

Aim of the study
The aim of the study was the microbiological identification of the bacterial strains which are found on CGM sensor electrodes.

Material and methods
We performed microbiological tests on patients′ CGM Enlite Medtronic electrodes, which were removed after 6 days of usage according to the manufacturer′s instructions. 31 sensors were examined from 31 children (14 girls) aged from 0.5 to 14.6 years. The microbiological analysis was routinely performed at the Department of Children’s Diabetology Medical University of Silesia in Katowice, Poland.

Results
12 (39%) of the electrodes were colonized. In 11 (92%) cases the electrodes were colonized by one bacteria strain. 7 times methicillin-sensitive coagulase negative staphylococcus (MSCNS) was detected. We also found one case of Klebsiella pneumoniae, Ochrobactrum tritici, Bacillus sonorensis and methicillin-resistant coagulase-negative Staphylococci (MRCNS) colonization. One electrode was colonized by the mixed flora Enterococcus faecalis, methicillin-susceptible coagulase-negative Staphylococci (MSCNS), Pseudomonas stutzeri, methicillin-susceptible Staphylococcus aureus (MSSA). The median HbA1c in the group with colonization of electrodes was 6, 85% (6, 3–7, 6%) versus 6, 3% (5, 8–7, 5%) in the group without colonization. The median BMI in the group with colonization of the electrodes was 17.10 kg/m2 (16.28–18.62 kg/m2) versus 15.98 kg/m2 (15.14–17.96 kg/m2) in the group without colonization. Statistically, significantly more frequently electrodes are colonized in older children (median age in the group with colonization of electrodes 11.43 years (6.52–12.27 years), without colonization 8.42 years. (3.098–9.375 years); (p = 0.033).

Conclusions
It seems that older children are more likely to have their sensor electrode colonized by bacterial strains.
Passive Wi-Fi monitoring in the wild: a long-term study across multiple location typologies
Authors: Ribeiro Miguel , Nunes Nuno , Nisi Valentina , Schöning Johannes 
Published: September 2020

AbstractIn this paper, we present a systematic analysis of large-scale human mobility patterns obtained from a passive Wi-Fi tracking system, deployed across different location typologies. We have deployed a system to cover urban areas served by public transportation systems as well as very isolated and rural areas. Over 4 years, we collected 572 million data points from a total of 82 routers covering an area of 2.8 km2. In this paper we provide a systematic analysis of the data and discuss how our low-cost approach can be used to help communities and policymakers to make decisions to improve people’s mobility at high temporal and spatial resolution by inferring presence characteristics against several sources of ground truth. Also, we present an automatic classification technique that can identify location types based on collected data.
Robust Estimation of Wage Dispersion with Censored Data: An Application to Occupational Earnings Risk and Risk Attitudes
Authors: Pollmann Daniel , Dohmen Thomas , Palm Franz 
Published: September 2020

AbstractWe present a semiparametric method to estimate group-level dispersion, which is particularly effective in the presence of censored data. We apply this procedure to obtain measures of occupation-specific wage dispersion using top-coded administrative wage data from the German IAB Employment Sample. We then relate these robust measures of earnings risk to the risk attitudes of individuals working in these occupations. We find that willingness to take risk is positively correlated with the wage dispersion of an individual’s occupation.
Building Bridges Between Self-Regulation and Cognitive Load—an Invitation for a Broad and Differentiated Attempt
Authors: Seufert Tina 
Published: September 2020

AbstractBuilding bridges between two of the most influential research fields in educational psychology, self-regulation and cognitive load theory, is highly relevant but also challenging. The collection of papers in this special issue reflects this interplay by reviewing the still scarce base of empirical data in an impressively elaborated and profound way. The papers offer different perspectives on how to improve learning by stimulating both activities for self-regulation as well as for reflecting the mental effort which can be used in return for monitoring and regulation. They provide arguments for the two sidedness of the relationship of self-regulation and cognitive load: that cognitive load can cause self-regulation and that self-regulation can cause cognitive load. The common understanding of self-regulation in this issue is very much focused on monitoring and could benefit from a broader view by including the whole cycle of self-regulation and moderating motivational factors like self-efficacy, as proposed in many self-regulation models. The conceptualization of effort, as it is referred to in most of the papers, could also profit from a more differentiated view, which takes into account the origin of required or invested mental effort. Overall, what learners actually decide to do when dealing with self-regulation as well as with cognitive load highly depends on their resources. In an integrative model, the role of potential resources is discussed as a starting point for future research. This discussion invites for an even broader, more individualized, and differentiated view to add to the bridge-building attempts of this impressive collection of research.
Content valuation strategies for digital subscription platforms
Authors: Kübler Raoul , Seifert Rouven , Kandziora Michael 
Published: September 2020

AbstractFor digital video subscription platforms, creating and managing content portfolios are critical to acquire new customers, retain existing customers, leverage cross-sales, and generate advertising revenues. We treat content portfolios as a form of pure bundling which may vary in composition and attractiveness over time. Therefore, evaluating the value contribution of each content piece is essential to manage a platform’s portfolio efficiently and to understand how a specific content piece contributes to the bundle’s attractiveness. In this article, we develop an ROI content valuation framework for a digital film subscription platform. This framework describes how a single piece of content diffuses through consumers’ journeys and influences subscription fees through acquisition and retention as well as revenues from cross-sales and advertising. This conceptual approach allows us to address the heterogeneity across content and platform contingencies such as exclusive availability and platform specifics, and link them to revenue streams. Building on this framework, we offer avenues for future research and provide potential lead performance indicators together with their operationalization, enabling all parties involved in the production, marketing, distribution, and sales of content to determine the platform-specific value of a content piece.
Nutritional Status and Obstacles to Healthy Eating Among Refugees in Geneva
Authors: Amstutz Delphine , Gonçalves Daniela , Hudelson Patricia , Stringhini Silvia , Durieux-Paillard Sophie , Rolet Sylvie 
Published: September 2020

AbstractRefugees face various nutritional challenges during and after migration. This cross-sectional, mixed-methods study seeks to investigate the prevalence of undernutrition and obesity among refugees in Geneva, and to identify barriers to healthy eating. Anthropometric measurements of 354 adult refugees were collected between 2017 and 2019 by trained nurses and dietitians. Seven focus group discussions totaling 51 participants, refugees and social workers, investigated conceptions and needs regarding diet. The mean Body Mass Index is 24.6 ± 4.8 kg/m2. Women are disproportionately affected by obesity compared to men (p < 0.001). Weight gain post-migration is correlated positively with length of stay in Geneva (p < 0.001). Major obstacles to healthy eating are economic and linguistic. For participants, cooking workshops and free physical activities are highly needed interventions. Post-migration lifestyle interventions should be implemented to prevent weight gain in this population. Such interventions must be multi-level, to overcome structural, social and behavioral barriers to healthy eating.
Including sediment in European River Basin Management Plans: twenty years of work by SedNet
Authors: Brils Jos 
Published: September 2020

Abstract
Purpose
This paper describes the efforts made by SedNet—the European Sediment Network—to generate attention for the inclusion of sediment in River Basin Management Plans (RBMPs) under the European Water Framework Directive (WFD).

Materials and methods
The SedNet response to key WFD implementation events is described using the “three-streams and windows-of-opportunities model” published by John Kingdon in 1995.

Results and discussion
SedNet was initially a response to the realization that the WFD—which came into force in 2000—largely neglected sediment. For SedNet, it was clear from the beginning that the WFD objectives can be achieved only if sediment is included in RBMPs. The SedNet efforts inspired the establishment of a sediment management concept for the Elbe river basin. That concept was used as a basis for the full inclusion of sediment in the second Elbe RBMP (2015–2021). SedNet experts are currently involved in the drafting of the WFD Common Implementation Strategy (CIS) sediment document which will be completed in 2021 and that will provide guidance about how to include sediment in RBMPs.

Conclusions
Since 2000, SedNet has persistently drawn attention to the need to include sediment in RBMPs. However, it was not until 2015 that the Elbe became the first European river basin to include sediment management fully in their RBMP. The 2021 WFD CIS sediment document and the focus on sediment in the Water Fitness Check in 2019 make it significantly more likely that the sediment will be included in the updates of WFD RBMPs in the near future.
User preferences for coworking spaces; a comparison between the Netherlands, Germany and the Czech Republic
Authors: Appel-Meulenbroek Rianne , Weijs-Perrée Minou , Orel Marko , Gauger Felix , Pfnür Andreas 
Published: September 2020

AbstractCoworking spaces have become a central component of new work environments, with large international chains. The purpose of this study is to investigate whether user preferences for the physical workspace design are consistent across countries, which the uniformity of such chains seems to suggest. A comparison between the user preferences of coworking spaces between the Netherlands (n = 219), Germany (n = 98) and the Czech Republic (n = 79) is performed using a mixed multinomial logic model for each country. Besides statistical utility of attributes, also motivations for working in coworking spaces are analysed. The findings show that there are some consistencies in preferences across countries. Typical real estate characteristics like accessibility and contract options came forward to be the most important attributes in choosing which coworking space to work at in all three countries. However, significant differences in the desired quality levels of specifically these attributes were found between the countries as well, and only the less important attributes showed similar preferences internationally. This suggests that identical world-wide implementations of the same concept, might serve multi-nationals but possibly will not attract local users. The identified differences in preferences can help to position more specific, dedicated coworking spaces within local markets.
Causes and Management of Non-cirrhotic Portal Hypertension​
Authors: Gioia Stefania , Nardelli Silvia , Ridola Lorenzo , Riggio Oliviero 
Published: September 2020

Abstract
Purpose of the Review
Non-cirrhotic portal hypertension (NCPH) includes a heterogeneous group of conditions. The aim of this paper is to make an overview on the denominations, diagnostical features and management of porto-sinusoidal vascular disease (PSVD) and chronic portal vein thrombosis (PVT) being the main causes of NCPH in the Western world.

Recent Findings
The management of NCPH consists in the treatment of associated diseases and of portal hypertension (PH). PH due to PSVD or PVT is managed similarly to PH due to cirrhosis. TIPS placement and liver transplantation are considerable options in patients with refractory variceal bleeding/ascites and with progressive liver failure. Anticoagulation is a cornerstone both in the treatment of thrombosis in PSVD and in the prevention of thrombosis recurrence in patients with portal cavernoma.

Summary
Physicians should be aware of the existence of PSVD and chronic PVT and actively search them in particular settings. To now, the management of portal hypertension-related complications in NCPH is the same of those of cirrhosis. Large cooperative studies on the natural history of NCPH are necessary to better define its management.
Mapping post-Brexit environmental law
Authors: Reid Colin T. 
Published: September 2020

AbstractThe UK’s withdrawal from the EU will not bring about immediate changes to the substance of environmental law in the UK, but that law will become easier to change. The future position is complicated by devolution within the UK, where differing policy objectives on continuing alignment with the EU and weaknesses in the inter-governmental structures are causing problems. Environmental principles are being given legal recognition and new structures for environmental governance being created for each nation. These include environmental watchdogs that go some of the way to making up for the loss of the oversight provided by the EU institutions.
Wiring the Brain by Clustered Protocadherin Neural Codes
Authors: Wu Qiang , Jia Zhilian 
Published: September 2020

AbstractThere are more than a thousand trillion specific synaptic connections in the human brain and over a million new specific connections are formed every second during the early years of life. The assembly of these staggeringly complex neuronal circuits requires specific cell-surface molecular tags to endow each neuron with a unique identity code to discriminate self from non-self. The clustered protocadherin (Pcdh) genes, which encode a tremendous diversity of cell-surface assemblies, are candidates for neuronal identity tags. We describe the adaptive evolution, genomic structure, and regulation of expression of the clustered Pcdhs. We specifically focus on the emerging 3-D architectural and biophysical mechanisms that generate an enormous number of diverse cell-surface Pcdhs as neural codes in the brain.