bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are e-learning Webinars the future of medical education? An exploratory study of a disruptive innovation in the COVID-19 era
Authors: McMahon Colin J. , Tretter Justin T. , Faulkner Theresa , Krishna Kumar R. , Redington Andrew N. , Windram Jonathan D. 
Published: December 2020

AbstractObjective:This study investigated the impact of the Webinar on deep human learning of CHD.Materials and methods:This cross-sectional survey design study used an open and closed-ended questionnaire to assess the impact of the Webinar on deep learning of topical areas within the management of the post-operative tetralogy of Fallot patients. This was a quantitative research methodology using descriptive statistical analyses with a sequential explanatory design.Results:One thousand-three-hundred and seventy-four participants from 100 countries on 6 continents joined the Webinar, 557 (40%) of whom completed the questionnaire. Over 70% of participants reported that they “agreed” or “strongly agreed” that the Webinar format promoted deep learning for each of the topics compared to other standard learning methods (textbook and journal learning). Two-thirds expressed a preference for attending a Webinar rather than an international conference. Over 80% of participants highlighted significant barriers to attending conferences including cost (79%), distance to travel (49%), time commitment (51%), and family commitments (35%). Strengths of the Webinar included expertise, concise high-quality presentations often discussing contentious issues, and the platform quality. The main weakness was a limited time for questions. Just over 53% expressed a concern for the carbon footprint involved in attending conferences and preferred to attend a Webinar.Conclusion:E-learning Webinars represent a disruptive innovation, which promotes deep learning, greater multidisciplinary participation, and greater attendee satisfaction with fewer barriers to participation. Although Webinars will never fully replace conferences, a hybrid approach may reduce the need for conferencing, reduce carbon footprint. and promote a “sustainable academia”.
The different surgical impact of the superior cavoatrial incision in children and adults
Authors: Ait-Ali Lamia , Ravaglioli Antonio , Festa Pierluigi , Tamburrini Alessandro , Marrone Chiara , Cuman Magdalena , Farnetani Cecilia , Pak Vitali , Chiavarelli Mario , Federici Duccio 
Published: December 2020

AbstractIntroduction:The single- and double-patch repairs are undoubtedly the most commonly used techniques for the surgical management of partial anomalous pulmonary venous connection associated with sinus venosus atrial septal defect. The aim of this study was to retrospectively compare early and long-term surgical outcomes in paediatric and adult patients, focusing in particular on the occurrence of ectopic atrial rhythm.Material and methods:Seventy patients (male: 38, 54.2%) underwent surgical repair for partial anomalous pulmonary venous connection with sinus venosus atrial septal defect. Forty-nine patients (70%) underwent surgical repair in paediatric age (<16 years old), while 21 of (30%) patients were operated in adulthood. Thirty patients (42.8%) underwent single-patch repair and 39 patients (55.7%) underwent double-patch repair. In only one patient, the Warden procedure was performed (1.4%). Median follow-up time was 52 months (IQ 15.1–113).Results:The type of surgical technique didn’t affect the incidence of ectopic atrial rhythm (26.6% in single-patch group and 25.6% in double-patch groups, p = 0.9). At long-term follow-up, ectopic atrial rhythm, as an expression of sinoatrial node disturbance, was however significantly more frequent in the paediatric population (28.8% paediatric group and 4.7% adult group, p = 0.02).Conclusions:The higher incidence of ectopic atrial rhythm in children is probably related to the closer position of the sinus node to the superior cavoatrial incision, which makes irreversible iatrogenic traumatism more likely to occur. Surgical techniques that avoid any manipulation on the superior cavoatrial junction should, therefore, be preferred for children undergoing partial anomalous pulmonary venous connection repair.
The more that households prioritise healthy eating, the better they can afford to consume a sufficient quantity and variety of fruits and vegetables
Authors: Stewart Hayden , Hyman Jeffrey , Dong Diansheng , Carlson Andrea 
Published: December 2020

AbstractObjective:To examine the variety of fruits and vegetables lower income households in the USA can buy while meeting Federal dietary recommendations at different levels of expenditure.Design:Simulation techniques were used to create 3000 market baskets of fruits and vegetables. All baskets contained enough food for a four-person household to meet dietary recommendations for fruits and vegetables over 1 week. Each basket’s retail value was estimated along with the ability of a representative household to afford each basket with different levels of expenditure.Setting:We used data from the US Department of Agriculture’s (USDA) Fruit and Vegetable Prices data product which reports a US household’s costs to buy each of 157 different fruit and vegetable products per edible cup equivalent.Participants:We consider the situation facing a lower income household that receives maximum benefits through the Supplemental Nutrition Assistance Program (SNAP). These benefits are enough for the household to obtain a nutritious and palatable diet without spending any of its own money on food if it approximately follows USDA’s Thrifty Food Plan.Results:Households receiving maximum SNAP benefits can buy a sufficient variety and quantity of fruits and vegetables if they allocate about 40 % of those benefits to these two food groups. However, if households spend less than that amount, the variety of products they can buy while still satisfying recommendations drops off quickly.Conclusion:Households that move fruits and vegetables to the centre of their budgets can better afford to meet Federal dietary guidelines.
Exploring healthcare professionals’ views of the acceptability of delivering interventions to promote healthy infant feeding practices within primary care: a qualitative interview study
Authors: Toomey Elaine , Flannery Caragh , Matvienko-Sikar Karen , Olander Ellinor K , Hayes Catherine , Heffernan Tony , Hennessy Marita , McHugh Sheena , Queally Michelle , Kearney Patricia M , Byrne Molly , Heary Caroline 
Published: December 2020

AbstractObjective:Early-life nutrition plays a key role in establishing healthy lifestyles and preventing chronic disease. This study aimed to (1) explore healthcare professionals’ (HCP) opinions on the acceptability of and factors influencing the delivery of interventions to promote healthy infant feeding behaviours within primary care and (2) identify proposed barriers/enablers to delivering such interventions during vaccination visits, to inform the development of a childhood obesity prevention intervention.Design:A qualitative study design was employed using semi-structured telephone interviews. Data were analysed using qualitative content analysis; findings were also mapped to the Theoretical Framework of Acceptability (TFA).Setting:Primary care in IrelandParticipants:Twenty-one primary care-based HCP: five practice nurses, seven general practitioners, three public health nurses, three community dietitians and three community medical officers.Results:The acceptability of delivering interventions to promote healthy infant feeding within primary care is influenced by the availability of resources, HCP’s roles and priorities, and factors relating to communication and relationships between HCP and parents. Proposed barriers and enablers to delivering interventions within vaccination visits include time constraintsv. opportunistic access, existing relationships and trust between parents and practice nurses, and potential communication issues. Barriers/enablers mapped to TFA constructs of Affective Attitude, Perceived Effectiveness and Self-Efficacy.Conclusions:This study provides a valuable insight into HCP perspectives of delivering prevention-focused infant feeding interventions within primary care settings. While promising, factors such as coordination and clarity of HCP roles and resource allocation need to be addressed to ensure acceptability of interventions to HCP involved in delivery.
Seven-year trends in the availability, sugar content and serve size of single-serve non-alcoholic beverages in New Zealand: 2013–2019
Authors: Gontijo de Castro Teresa , Eyles Helen , Ni Mhurchu Cliona , Young Leanne , Mackay Sally 
Published: December 2020

AbstractObjective:To assess trends in relative availability, sugar content and serve size of ready-to-drink non-alcoholic beverages available for sale in supermarkets from 2013 to 2019.Design:Repeat cross-sectional surveys. Data on single-serve beverages to be consumed in one sitting were obtained from an updated brand-specific food composition database. Trends in beverages availability and proportions with serve size ≤ 250 ml were assessed by χ2 tests. Sugar content trends were examined using linear regressions. The proportion of beverages exceeding the sugar threshold of the United Kingdom Soft Drinks Industry Levy (SDIL) was assessed.Setting:New Zealand.Results:From 2013 to 2019, there was (i) an increase in the availability of sugar-free/low-sugar beverages (n 25 (8·4 %) to n 75 (19·1 %); P < 0·001) and craft sugar-sweetened soft drinks (n 11 (3·7 %) to n 36 (9·2 %); P < 0·001), and a decrease in availability of fruit/vegetable juices/drinks (n 94 (31·8 %) to n 75 (19·4 %); P < 0·001); (ii) small decreases in sugar content (mean g/100 ml) of sugar-sweetened soft drinks (3·03; 95 % CI 3·77, 2·29); fruit/vegetable juices/drinks (1·08; 95 % CI 2·14, 0·01) and energy drinks (0·98; 95 % CI 1·63, 0·32) and (iii) slight reduction in the proportion of beverages with serve size ≤ 250 ml (21·6 to 18·9 %; P < 0·001). In 2019, most beverages were sugar-sweetened or had naturally occurring sugars (79·1 %) and serve size > 250 ml (81·1 %) and most sugar-sweetened beverages exceeded the SDIL lower benchmark (72·9 %).Conclusions:Most single-serve beverages available for sale in 2019 were sugary drinks with high sugar content and large serve sizes; therefore, changes made across the years were not meaningful for population’s health.
Contexts of State Violence: Jewish Expulsions in the Holy Roman Empire
Authors: Doten-Snitker Kerice 
Published: December 2020

AbstractPolicies excluding ethnoracial and religious minorities reinforce the power of political elites. This study addresses an extreme case of exclusion: urban expulsions of Jews in the medieval western Holy Roman Empire. Expulsions were official edicts proclaimed by Christian princes, lords, or town councils, whomever ruled a territory. Changing religious and political culture, in the form of new value on community righteousness and the beginning of territorialization, provided incentives for polities to expel their Jewish residents. Using a new database of Jewish settlement and city development in the Western Holy Roman Empire 1000–1520 CE, I show that the relational structure of political power between Christian elites could insulate or expose Jewish communities to political contests of the time. Jews were derided, lesser members of Christian society, but in spite of increasing focus on Christian piety and legislating community purity, most cities did not expel their Jewish residents. City rulers that did expel were attempting to solve challenges for sovereignty through their policies toward Jews.
From Anthropocene to Noosphere: The Great Acceleration
Authors: Shoshitaishvili Boris 
Published: December 2020

AbstractThe complex set of human‐driven global, social, technological, and environmental changes intensifying dramatically since 1950 has been identified as the “Great Acceleration.” This period of time represents a radical shift in our collective relationship to each other as well as to the Earth system as a whole. In this article I consider two major paradigms now taking shape to offer different perspectives on the Great Acceleration: The Anthropocene and the Noosphere. I explore the scientific‐intellectual traditions from which each paradigm derives and contrast their nearly opposite normative evaluations of global transformation. The Anthropocene has emerged as the paradigm of rupture, materiality, and warning; the Noosphere as the paradigm of development, mind/culture, and hope. I also highlight preliminary attempts at bringing the two divergent paradigms closer together into a more unified and balanced vision of planetary change.
Particulate Backscattering in the Global Ocean: A Comparison of Independent Assessments
Authors: Bisson K. M. , Boss E. , Werdell P. J. , Ibrahim A. , Behrenfeld M. J. 
Published: December 2020

AbstractHow well do we know the particulate backscattering coefficient (bbp) in the global ocean? Satellite lidar bbp has never been validated globally and few studies have compared lidar bbp to bbp derived from reflectances (via ocean color) or in situ observations. Here, we validate lidar bbp with autonomous biogeochemical Argo floats using a decorrelation analysis to identify relevant spatiotemporal matchup scales inspired by geographical variability in the Rossby radius of deformation. We compare lidar, float, and ocean color bbp at the same locations and times to assess performance. Lidar bbp outperforms ocean color, with a median percent error of 18% compared to 24% in the best case and a relative bias of −11% compared to −21%, respectively. Phytoplankton carbon calculated from ocean color and lidar exhibits basin‐scale differences that can reach ±50%.
Do CMIP6 Climate Models Simulate Global or Regional Compound Events Skillfully?
Authors: Ridder Nina N. , Pitman Andrew J. , Ukkola Anna M. 
Published: December 2020

AbstractCompound events have the potential to cause high socioeconomic and environmental losses. We examine the ability of the sixth phase of the Coupled Model Intercomparison Project (CMIP6) models to capture two bivariate compound events: the co‐occurrence of heavy rain and strong wind, and heat waves and meteorological drought. We evaluate the models over North America, Europe, Eurasia, and Australia using observations and reanalysis data set spanning 1980–2014. Some of the CMIP6 models capture the return periods of both bivariate compound events over North America, Europe, and Eurasia surprisingly well but perform less well over Australia. For heavy rain and strong wind, this poor performance was particularly clear in northern Australia which suggests limits in simulating tropical and extratropical cyclones, local convection, and mesoscale convective systems. We did not find higher model resolution improved performance in any region. Overall, our results show some CMIP6 models can be used to examine compound events, particularly over North America, Europe, and Eurasia.
Energy Imbalance and Evapotranspiration Hysteresis Under an Advective Environment: Evidence From Lysimeter, Eddy Covariance, and Energy Balance Modeling
Authors: Dhungel Ramesh , Aiken Robert , Evett Steven R. , Colaizzi Paul D. , Marek Gary , Moorhead Jerry E. , Baumhardt R. Louis , Brauer David , Kutikoff Seth , Lin Xiaomao 
Published: December 2020

AbstractSurface energy imbalance problems have been underexplored especially under advective environments. Here, we present a novel analysis of surface energy fluxes from three distinct approaches—weighing lysimeter, eddy covariance (EC), and surface energy balance modeling for the 2014 sorghum and 2016 corn crop seasons in Bushland, Texas. Our results suggest that energy imbalance problems in the EC system were evidently associated with two opposite evapotranspiration (ET) hysteresis patterns with respect to net radiation and water vapor pressure deficit (VPD). The lysimeter ET had the smallest ET hysteresis while the eddy covariance ET results indicated the strongest hysteresis with respect to net radiation. Conversely, the lysimeter ET hysteresis related to water VPD was stronger than that of the eddy covariance method. This study provides understanding of ET hysteresis patterns, energy imbalance, and advective conditions associated with turbulent flux dynamics for both diel and crop growing seasonal timescales in Bushland, Texas.
Sub‐Seasonal Tree‐Ring Reconstructions for More Comprehensive Climate Records in U.S. West Coast Watersheds
Authors: Wise Erika K. 
Published: December 2020

AbstractTree‐ring records of preinstrumental hydroclimate, which contribute needed context for understanding recent drought and flood events, typically provide one value per year that represents the entire year or one particular season. This may introduce a seasonal bias to the records or omit seasonally variable moisture. Here, I use tree‐ring records to reconstruct precipitation and runoff in 28 U.S. West Coast watersheds for running 1, 3, 6, and 12‐month intervals. When compared on a yearly basis, the Monthly and Four‐Season models have higher overall skill and better extreme capture in most basins than the Cool‐Warm and Annual models. The Monthly and Four‐Season versions also decrease model error in years with more intense precipitation and retain more variability in the preinstrumental period. Improved capture of year‐round moisture can provide a more complete representation of the preinstrumental past and strengthen capacity to study shorter‐duration and season‐specific events like atmospheric rivers.
The genie in the bottle-magnified calcium signaling in dorsolateral prefrontal cortex
Authors: Arnsten Amy F. T. , Datta Dibyadeep , Wang Min 
Published: December 2020

AbstractNeurons in the association cortices are particularly vulnerable in cognitive disorders such as schizophrenia and Alzheimer’s disease, while those in primary visual cortex remain relatively resilient. This review proposes that the special molecular mechanisms needed for higher cognitive operations confer vulnerability to dysfunction, atrophy, and neurodegeneration when regulation is lost due to genetic and/or environmental insults. Accumulating data suggest that higher cortical circuits rely on magnified levels of calcium (from NMDAR, calcium channels, and/or internal release from the smooth endoplasmic reticulum) near the postsynaptic density to promote the persistent firing needed to maintain, manipulate, and store information without “bottom-up” sensory stimulation. For example, dendritic spines in the primate dorsolateral prefrontal cortex (dlPFC) express the molecular machinery for feedforward, cAMP–PKA–calcium signaling. PKA can drive internal calcium release and promote calcium flow through NMDAR and calcium channels, while in turn, calcium activates adenylyl cyclases to produce more cAMP–PKA signaling. Excessive levels of cAMP–calcium signaling can have a number of detrimental effects: for example, opening nearby K+channels to weaken synaptic efficacy and reduce neuronal firing, and over a longer timeframe, driving calcium overload of mitochondria to induce inflammation and dendritic atrophy. Thus, calcium–cAMP signaling must be tightly regulated, e.g., by agents that catabolize cAMP or inhibit its production (PDE4, mGluR3), and by proteins that bind calcium in the cytosol (calbindin). Many genetic or inflammatory insults early in life weaken the regulation of calcium–cAMP signaling and are associated with increased risk of schizophrenia (e.g.,GRM3). Age-related loss of regulatory proteins which result in elevated calcium–cAMP signaling over a long lifespan can additionally drive tau phosphorylation, amyloid pathology, and neurodegeneration, especially when protective calcium binding proteins are lost from the cytosol. Thus, the “genie” we need for our remarkable cognitive abilities may make us vulnerable to cognitive disorders when we lose essential regulation.
Metabolic modeling predicts specific gut bacteria as key determinants for Candida albicans colonization levels
Authors: Mirhakkak Mohammad H , Schäuble Sascha , Klassert Tilman E , Brunke Sascha , Brandt Philipp , Loos Daniel , Uribe Ruben V , Senne de Oliveira Lino Felipe , Ni Yueqiong , Vylkova Slavena , Slevogt Hortense , Hube Bernhard , Weiss Glen J , Sommer Morten O A , Panagiotou Gianni 
Published: December 2020

Abstract
Candida albicans is a leading cause of life-threatening hospital-acquired infections and can lead to Candidemia with sepsis-like symptoms and high mortality rates. We reconstructed a genome-scale C. albicans metabolic model to investigate bacterial-fungal metabolic interactions in the gut as determinants of fungal abundance. We optimized the predictive capacity of our model using wild type and mutant C. albicans growth data and used it for in silico metabolic interaction predictions. Our analysis of more than 900 paired fungal–bacterial metabolic models predicted key gut bacterial species modulating C. albicans colonization levels. Among the studied microbes, Alistipes putredinis was predicted to negatively affect C. albicans levels. We confirmed these findings by metagenomic sequencing of stool samples from 24 human subjects and by fungal growth experiments in bacterial spent media. Furthermore, our pairwise simulations guided us to specific metabolites with promoting or inhibitory effect to the fungus when exposed in defined media under carbon and nitrogen limitation. Our study demonstrates that in silico metabolic prediction can lead to the identification of gut microbiome features that can significantly affect potentially harmful levels of C. albicans.
Studying pre-treatment and ketamine-induced changes in white matter microstructure in the context of ketamine’s antidepressant effects
Authors: Sydnor Valerie J. , Lyall Amanda E. , Cetin-Karayumak Suheyla , Cheung Joey C. , Felicione Julia M. , Akeju Oluwaseun , Shenton Martha E. , Deckersbach Thilo , Ionescu Dawn F. , Pasternak Ofer , Cusin Cristina , Kubicki Marek 
Published: December 2020

AbstractKetamine is increasingly being used as a therapeutic for treatment-resistant depression (TRD), yet the effects of ketamine on the human brain remain largely unknown. This pilot study employed diffusion magnetic resonance imaging (dMRI) to examine relationships between ketamine treatment and white matter (WM) microstructure, with the aim of increasing the current understanding of ketamine’s neural mechanisms of action in humans. Longitudinal dMRI data were acquired from 13 individuals with TRD two hours prior to (pre-infusion), and four hours following (post-infusion), an intravenous ketamine infusion. Free-water imaging was employed to quantify cerebrospinal fluid-corrected mean fractional anisotropy (FA) in 15 WM bundles pre- and post-infusion. Analyses revealed that higher pre-infusion FA in the left cingulum bundle and the left superior longitudinal fasciculus was associated with greater depression symptom improvement 24 h post-ketamine. Moreover, four hours after intravenous administration of ketamine, FA rapidly increased in numerous WM bundles in the brain; this increase was significantly associated with 24 h symptom improvement in select bundles. Overall, the results of this preliminary study suggest that WM properties, as measured by dMRI, may have a potential impact on clinical improvement following ketamine. Ketamine administration additionally appears to be associated with rapid WM diffusivity changes, suggestive of rapid changes in WM microstructure. This study thus points to pre-treatment WM structure as a potential factor associated with ketamine’s clinical efficacy, and to post-treatment microstructural changes as a candidate neuroimaging marker of ketamine’s cellular mechanisms.