bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ist die Sarkoidose eine durch Vitamin D getriggerte Krebsabwehr?
Authors: von Helden Raimund , Grant William B. , Moukayed Meis , Becker Bernd 
Published: January 2020

ZusammenfassungDie Ursache der Sarkoidose ist bislang unbekannt. Vitamin D ist zur Behandlung der Erkrankung kontraindiziert. Wir fragen daher, was Sarkoidose verursacht und warum Vitamin D für die Betroffenen gefährlich sein kann und schlagen eine gegenteilige Hypothese vor: Sarkoidose ist ein physiologischer Prozess der Krebsabwehr, der Vitamin D als Substrat benötigt. Zur Prüfung der Hypothese haben wir anhand einer Literaturrecherche zahlreiche Fallberichte über Sarkoidose und Krebs gefunden sowie Fälle von Krebsmimikry durch Sarkoidose. Mehrere Berichte beschreiben Spontanheilungen der Krebserkrankung bei gleichzeitigem Auftreten einer Sarkoidose. Im Zusammenhang mit den Granulomen der Sarkoidose bilden Monozyten den Ort der Vitamin-D-Freisetzung. Darüber hinaus kann aktives Vitamin D Krebszellen mithilfe der Vitamin-D-Rezeptoren des Zellkerns kontrollieren. Dass Granulome „nicht verkäsend“ sind, wird als Resorption von humanen Molekülen der Krebszellen erklärt. Der Umstand, dass in den Granulomen der Sarkoidose meist Krebszellen fehlen, wird als Ergebnis einer gut funktionierenden Sarkoidose interpretiert. Wir betrachten die typische Synthese von aktivem Vitamin D in den Sarkoidose-Monozyten als Krebsabwehr. Die Hypothese muss durch weitere Untersuchungen untermauert werden.
Low Sugar und High Dose Vitamin C
Authors: Holzhauer Peter 
Published: January 2020

ZusammenfassungDie hochdosierte parenterale Applikation von Vitamin C wird häufig als komplementäre Supportivtherapie bei tumorassoziierter Fatigue-Symptomatik eingesetzt 1
3. Die vorgestellte Kasuistik beschreibt eine folgenreiche Wechselwirkung dieser medikamentösen supportiven Therapie mit einem High Tech Medizinprodukt 2. Eine 55-jährige Patientin mit metastasiertem triple negativem Mammakarzinom erhält eine Chemotherapie mit Gemcitabin. Die Auswahl dieses Zytostatikums erfolgte auf dringenden Wunsch der Patientin auf der Basis einer von der Patientin initiierten Liquid Biopsy. Einen Tag nach Applikation der Chemotherapie erhielt die Patientin 7,5 g Vitamin C als Kurzinfusion über 30 Minuten. 3 Stunden später erlitt sie einen generalisierten Krampfanfall und war nicht mehr ansprechbar. Die Messung des Blutzuckers ergab eine Hypoglykämie mit einem Blutzuckerwert von 48 mg/dl. Nach intravenöser Glukosegabe rekompensierte sie schnell. Der kausale Zusammenhang wird beschrieben.
Drug-Induced Liver Injury (DILI) in Patients with Depression Treated with Antidepressants: A Retrospective Multicenter Study
Authors: Ueberberg Bianca , Frommberger Ulrich , Messer Thomas , Zwanzger Peter , Kuhn Jens , Anghelescu Ion , Ackermann Katharina , Assion Hans-Jörg 
Published: January 2020

Abstract
Introduction Drug-induced liver injury (DILI) is the 4th most common cause of liver damage in Western countries and can be caused by antidepressants.
Methods Against the background of increasing antidepressant prescriptions and increasing use of polypharmacy, we analyzed administered antidepressants and other pharmacological substances, liver toxicity, comorbid somatic secondary diseases together with the occurrence of DILI in a patient population of 6 centers throughout Germany.
Results The majority of the enrolled 329 patients received polypharmacological treatment in an inpatient setting. During antidepressant treatment 5.1% of the patients had elevated serum transaminase levels, whereby exactly and not more than 1 criterion proposed to be indicative for DILI, was fulfilled by 3 patients (0.9%).
Discussion During patient characterization it becomes clear that a sensitization for relevant risk constellations causing liver injury in MDD patients is relevant to prevent further serious adverse events.
A Reduction in Match-to-match Variability Using Maximal Mean Analyses in Sub-elite Soccer
Authors: Lord Cameron , Blazevich Anthony John , Abbiss Chris Richard , Maʼayah Fadi 
Published: January 2020

AbstractThe match-to-match variability of external loads in National Premier League soccer competition was determined. Global positioning systems (GPS) data were collected from 20 sub-elite soccer players over 2–10 matches from a single season. Match data were collected from during one season. Twenty-six matches were recorded and 10 were utilised within final match-to-match analysis based on stringent data selection criteria. A symmetric moving average algorithm was applied to GPS data over specific time windows (1, 5, 10, 60, 300 and 600 s), and maximal speed and metabolic power values then calculated at each time interval during each match. Match-to-match coefficients of variation (CV) were greatest for sprint-speed running distance (36.3–43.6%) when comparing 2 vs. 10 matches. CVs for maximal mean speed (4.9–7.0%) and metabolic power (4.4–9.6%) ranged from good to moderate. As the variability of absolute high-speed distance values are greater, and therefore less reliable, their use as indicators of performance is reduced, suggesting that maximal mean analyses could be used as an alternative in the assessment of match running performance during competitive matches.
Angiopoietin 2 and Neuropeptide Y are Associated with Diabetic Kidney
Disease in Type 1 Diabetes Mellitus
Authors: Sokolovska Jelizaveta , Stefanovics Juris , Gersone Gita , Pahirko Leonora , Valeinis Janis , Kalva-Vaivode Sanita , Rovite Vita , Blumfelds Leons , Pirags Valdis , Tretjakovs Peteris 
Published: January 2020

Abstract
Background Serum angiopoietin 2 levels have been associated with
endothelial dysfunction and diabetic kidney disease. Derangements in autonomous
nervous system lead to increased production of vasoconstrictory and angiogenic
mediators such as norepinephrine and neuropeptide Y and are associated with
increased risk of microvascular complications.
Aim To investigate associations between angiopoietin 2, neuropeptide Y
and diabetic kidney disease in patients with type 1 diabetes mellitus.
Methods 289 patients with type 1 diabetes mellitus duration > 1
year were included. Patients were stratified according to presence of diabetic
nephropathy (macroalbuminuria, estimated glomerular filtration
rate<60 ml/min/1.73 m2 or
end-stage renal disease). Angiopoietin 2 was measured by Luminex technology.
Neuropeptide Y was measured by ELISA.
Results Patients with diabetic nephropathy had significantly increased
levels of angiopoietin 2 (4020.5 (2172.4–5778.1) pg/ml
vs. 2001.0 (1326.7–2862.7) pg/ml) and
neuropeptide Y (18.22 (14.85–21.85) ng/ml vs.
12.91 (9.96–17.07) ng/ml). Higher levels of angiopoietin
2 and neuropeptide Y were observed also in patients with arterial hypertension.
Angiopoietin 2 and neuropeptide Y correlated significantly
(ρ=0.245, p<0.001). Both biomarkers were significant
predictors of estimated glomerular filtration rate and diabetic nephropathy in
univariate regression models. In the fully adjusted regression models and after
application of a stepwise selection regression method, angiopoietin 2
demonstrated a stronger predictive power for diabetic nephropathy compared to
neuropeptide Y.
Conclusion Diabetic nephropathy is associated with increased serum
concentrations of angiopoietin 2 (marker of endothelial dysfunction) and
neuropeptide Y (marker of sympathetic activity) in type 1 diabetes. Angiopoietin
2 is a more potent predictor of diabetic nephropathy compared to neuropeptide
Y.
Anterior versus posterior approach in peroral endoscopic myotomy (POEM): a systematic review and meta-analysis
Authors: Mohan Babu P. , Ofosu Andrew , Chandan Saurabh , Ramai Daryl , Khan Shahab R. , Ponnada Suresh , Adler Douglas G. 
Published: January 2020

Abstract
Background Peroral endoscopic myotomy (POEM) is increasingly being used as the endoscopic treatment option for achalasia. Data are limited as to the comparative efficacy of anterior vs. posterior myotomy.
Methods We searched multiple databases from inception to August 2019 to identify studies reporting on POEM. We selected studies that reported on the outcomes of POEM, along with information on myotomy approach. We performed a comparative analysis of clinical success, gastroesophageal reflux disease (GERD), and adverse events with anterior and posterior myotomy in POEM by meta-analysis.
Results 1247 patients from 18 studies were analyzed: 623 patients (11 cohorts) were treated via anterior myotomy and 624 patients (12 cohorts) via posterior myotomy. The pooled rate for clinical success gave an odds ratio (OR) of 1.02 (95 % confidence interval [CI] 0.52 – 2.0; I
2 0; P = 0.9); for GERD by esophagogastroduodenoscopy (EGD) was OR 1.02 (95 %CI 0.62 – 1.68; I
2 0; P = 0.9), and for GERD by pH was OR 0.98 (95 %CI 0.59 – 1.63; I
2 34; P = 0.9). The individual pooled rates of clinical success at 12 months and > 12 months, GERD (by symptoms, EGD, pH), and adverse events (mild, moderate, severe) were comparable. The pooled total procedure time with anterior myotomy was 82.7 minutes (95 %CI 69.0 – 96.4; I
2 98) and with posterior myotomy was 62.1 minutes (95 %CI 48.5 – 75.7; I
2 90).
Conclusion Anterior and posterior myotomy in POEM seem comparable to each other in terms of clinical success, GERD, and adverse events. The total procedure time with posterior myotomy seems to be shorter than with anterior myotomy.
Challenges and Opportunities in Reporting Trauma-Related Research: A Case Study from Syria
Authors: Alothman Muhammad Hussam , Tamer Wardan Almir , Moscote-Salazar Luis Rafael , Ghosh Amrita , Pal Ranabir , Agrawal Amit 
Published: January 2020

Abstract
Background Reporting war trauma research is an arduous mission because it needs accurate data collection and it is considered a tough task as a result of the emergent management nature of such injuries which implies neglecting the medical records. The conflict in Syria involved extreme numbers of war trauma injuries which might be implemented in creating a prototype for preparedness plans which might decrease the number of casualties or, at the very least, minimize the damage for future combat trauma injuries.
Material and Methods Data were sought from the Department of Surgery at Hama National Hospital on war injuries during 2017 to make a research paper on the experience of Hama National Hospital, Syria, a nonmilitary hospital that treats war injuries.
Results In 2017, 2,912 war injury patients were admitted to the Hama National Hospital, among which 683 (23.455%) were dead-on-arrival and the remaining 2,229 patients (76.545%) were treated in emergency room (ER). Among those treated in the ER, shrapnel was the first cause of injury reported in 1,165 patients (52.26%), followed by bullets in 585 (26.24%) and trauma in 316 (14.17%). There were no data on the age of patients, the initial investigations done, the Glasgow Coma Scale score on admission, the primary management, the follow-ups, or even the mortality rates among hospitalized patients. The data were insufficient to write a well-balanced research paper because of the scarcity of information extracted from the medical records.
Conclusion Doing a research in conflict settings requires more attention to detail and the medical staff should be trained to take care of the medical records because even if it seems inappropriate to spend time on recording in conflict atmospheres, making well-established recordings would contribute to the enhancement of the health care management of future war trauma injuries.
Testing the Neutrino Mass Ordering with Four Years of IceCube/DeepCore Data
Authors: Leuermann Martin 
Published: January 2020

Abstract
The measurement of the Neutrino Mass Ordering (NMO), i.e. the ordering of the neutrino mass eigenstates, is one of the major goals of many future neutrino experiments. One strategy is to measure matter effects in the oscillation pattern of atmospheric neutrinos as proposed for the PINGU extension of the IceCube Neutrino Observatory. Already, the currently running IceCube/DeepCore detector can explore this type of measurement. Albeit with lower significance, such a measurement can contribute to the current understanding. Furthermore, such an analysis exercises the measurement principle and evaluation of systematic uncertainties and thus prototypes future analyses with PINGU. We present a likelihood analysis spanning multiple years of IceCube data searching for indications of the NMO with a data sample reaching to energies below 10 GeV.
Isolation of Cellulolytic Bacteria from Mangrove Sediment in Dumai Marine Station Riau and the Antibacterial Activity against Pathogens
Authors: Nursyirwani N , Feliatra F , Tanjung A , Harjuni F 
Published: January 2020

Abstract
Cellulolytic bacteria are a group of bacteria that have an ability to degrade material containing cellulose and have potency to inhibit the growth of pathogenic bacteria. The bacteria can be found in soil or sediment in the mangrove ecosystem. This research aimed to: 1) isolate cellulolylitic bacteria from mangrove sediments in Dumai Marine Station, of Riau, Indonesia, 2) to examine the antagonism against pathogenic bacteria (Escherichia coli, Pesudomonas aeruginosa, Vibrio alginolyticus), and 3) to identify and the phenotype and genetic characters of the potential isolates. The bacteria were isolated on Zobell Marine Agar 2216 added with carboxymethyl cellulose (CMC). Cellulolytic index value was obtained by reducing clear zone diameter with the bacterial colony diameter. Disc diffusion agar method was used to examine antagonism of selected isolates against pathogens. The isolates were observed for the colony and cell morphology, biochemical and genetically characters. Twenty four isolates showed cellulolytic activity and index values ranged from 1.00 to 2.86 and 0.01 to 2.12, respectively. Nine of selected isolates performed ranges of zone inhibition against E. coli, P. aeruginosa and V. alginolyticus from 2.38 ± 0.21 mm to 3.58 ± 0.83 mm, 2.75 ± 0. 59 mm - 4.81 ± 0.57 mm and 2.28 ± 0.45 mm - 4.68 ± 1.40 mm, respectively. Based on the 16S rDNA sequence analysis, three cellulolytic isolates indicated similarity to Bacillus toyonensis (99.53 %).
Effects of Various Carbon Doses on Tilapia (Orechromis sp) Culture with Biofloc Technology
Authors: Putra I , Efendi I , Lukisyowati I , Tang U M , Rusliadi R , Manik R A 
Published: January 2020

Abstract
The purpose of this study was to evaluate the growth and survival of red tilapia (Oreochromis sp) which were cultured using biofloc technology with different amounts of molasses as a source of carbon. This study was carried out for 35 days in August-September 2017 at the Laboratory of Aquaculture Technology, Faculty of Fisheries and Marine Science, Universitas Riau, Pekanbaru, Indonesia. The experiment was done using a completely randomized design (CRD) with the following treatments: A: 50 ml/m3 molasses, B: 100 ml/m3 molasses, C: 150 ml/m3 molasses, and D: 200 ml/m3 molasses. The test fish used was red tilapia with a size of 3.57±0.06 cm and a weight of 1.14±0.09 g. Fish were kept in containers with a volume of 100 liters that are filled with brackish water with a salinity of 17 ppt. Feed was given at 3 times per day. Results showed significant effect of each treatment on the absolute weight and specific growth, but did not significantly affect the survival rate of red tilapia. Best growth and utilization of feed in red tilapia culture using biofloc technology was supplementing with add molasses at a dose of 200 ml / m3 (D).
Density of Mangrove Snail (Telescopium telescopium) in the Mangroves Ecosystem of Mengkapan Village, Sungai Apit Subdistrict, Siak District, Riau Province
Authors: Adriman A , Sumiarsih E , Andriani N 
Published: January 2020

Abstract
Mangrove snails (Telescopium telescopium) are found in the mangrove ecosystem. Telescopium telescopium has significant ecological and economical role in the mangrove ecosystem. This study aims to determine the density of mangrove snails in the mangrove ecosystem of Mengkapan village. This research was conducted in February 2018. There were 3 transect and there were 6 plots (1m x 1m). The snails were collected once/2 weeks, 3 time. Densities of the snail were studied. Results shown that in the density of the snail was 4.33–5.17 organisms/m2. The density of mangrove snail population in the mangrove ecosystem in the Mengkapan Village has no disturbance.
Prediction and modeling of roughness in ball end milling with tool-surface inclination
Authors: Bilek O , Milde R , Strnad J , Zaludek M , Bednarik M 
Published: January 2020

Abstract
The quality of mill finishing of shaped surfaces is influenced by a number of input parameters. Current automated manufacturing systems allow adaptation of the machining process aiming at the final surface quality. Despite all the advantages, these systems require a behavioural model, a prediction of the output, based on the input parameters. Some of these models are summarized in this paper, including contemporary evaluated models as well as their functional dependencies; moreover, offers an application of mill finishing with a ball-end cutter incorporating tool axis or surface inclination.
Influence of focal length on depth of engraved PMMA surface
Authors: Knedlová J , Sýkorová L , Pata V , Škrobák A 
Published: January 2020

Abstract
The paper focuses on laser cutting of polymer material PMMA. Specifically, the influence of optics on the engraved surface is investigated with use focal length lenses of 1.5″ 2.5″ 4″. Commercial CO2 laser ILS 3NM by Laser Tools & Technics Corp. Taiwan, was used for experimental machining.
The physical – mechanical properties of low-density polyethylene films
Authors: Markovičová L , Zatkalíková V , Kojnoková T , Gaňa D , Liptáková T 
Published: January 2020

Abstract
Polyethylene (PE) is the most commonly used polymer. Most of the polymers are processed by the packaging sector. PE products are the most recycled plastic due to the short life of packaging materials. The experiment is based on real issues in the recycling of plastic waste in a world that is increasingly up to date. One way of recycling it is to produce returnable plastic bottles that can be used up to 50 times. The low-density polyethylene (LDPE) film is applied to the plastic bottles before filling with a specific medium. After the contents of the bottle have been consumed, the LDPE film is stripped. Subsequently, a new recyclable film is applied to the bottles used and the process is repeated. Changes in the properties of LDPE films applied to these returnable bottles have been evaluated by several tests (tensile test and water absorption test). The tests were performed on unused LDPE films and on used LDPE films, which were filled with the medium for 3 months. The fill media was chosen from commonly available goods.
Susceptibility to the intergranular attack in austenitic stainless steels
Authors: Zatkalíková V , Markovičová L , Uhríčik M , Hanusová P 
Published: January 2020

AbstractIntergranular corrosion is very dangerous local corrosion form that often leads to the dislodgment of individual grains and to the intensive negative influence on the mechanical properties of the material. The susceptibility of the austenitic stainless steels to the intergranular corrosion is connected with their exposition in the temperature range of 500-800 °C (“critical temperatures”) and with consequent slow cooling in the air which leads to the precipitation of chromium-rich carbides at the grain boundaries. This process consumes chromium from a narrow band along the grain boundaries and the steel becomes to be sensitized and susceptible to the intergranular corrosion in aggressive environments. This article deals with the susceptibility to the intergranular corrosion of three austenitic stainless steels (AISI 304, 316L, 316Ti). Both “as received” and improperly heat treated specimens (sensitization for 10 hours at 650 °C, cooling in the air) were tested by ASTM A262 standard method, A and E practices. Optical microscopy and SEM analysis were used for the assessment of the obtained results.
Structural characteristics of NiTi alloys after thermal treatment
Authors: Drápala J , Losertová M , Štencek M , Konečná K , Matýsek D , Sevostyanov M A 
Published: January 2020

Abstract
The study of the effect of thermal treatment conditions on NiTi alloy used in biomedicine was carried out. The experimental samples of NiTi alloy with 55.8 wt% Ni were subjected to the heat treatment. The thermal regimes consisted of aging treatment at 300, 350 and 400 °C for 30 minutes followed by air cooling. The microstructures before and after the heat treatment were observed by optical microscopy. The study was completed by the microhardness measurement and XRD analysis. The obtained results show that the aging temperatures led to microstructural and microhardness changes for the investigated alloy.
Algorithm for J-Integral Measurements by Digital Image Correlation
Authors: Titkov V V , Eremin A V , Panin S V , Lyubutin P S , Kozulin A A 
Published: January 2020

Abstract
The work is devoted to the testing of the algorithm for calculating J-integral based on the construction of vector fields by digital image correlation (DIC) method. A comparative analysis of J-integral values calculated using DIC and instrumental data obtained in accordance with ASTM E 1820 “Standard Test Method for Measurement of Fracture Toughness” has made. It is shown that this approach can be used for cases when the standard technique for measuring the J-integral cannot be applied, or the standard technique does not allow achieving the required accuracy for the integral determination in local areas of the loaded material.
Research of the Materials and Reinforcement Schemes Effects on a Mechanical Behavior Smart Structure with Embedded Piezo Actuators
Authors: Anoshkin A N , Pisarev P V , Ashikhmin V A 
Published: January 2020

Abstract
The present work is devoted to the research of a helicopter blade segment stress-strain state. The segment was made of polymer composite materials with embedded piezoelectric actuators. The computational model of the blade segment takes into account the technological order of laying and the anisotropy of the reinforcing layers properties. The reinforcement schemes under consideration were [0°/90°], [45°/-45°], [0°/45°/-45°/90°]. The static strength margin was estimated using the criterion of maximum stresses. A layered analysis of the structure stress-strain state was carried out. It was shown that the most dangerous, determining the structure margin of safety, are normal interlayer stresses. It was found that the GFRP material and the structural reinforcement scheme [0°/90°], selected during the design, provide the greatest torsion angles.
Friction Induced Structural Changes of Mangalloy Observed by Synchrotron X-Ray Diffraction and Metallographic Analysis
Authors: Emurlaev K I , Ruktuev A. A. , Karmanova A E , Burov V G , Nikulina A A , Bataev I A 
Published: January 2020

Abstract
The effect of friction impact on structure and properties of mangalloy (Hadfield steel) was investigated. By means of metallographic analysis coupled with synchrotron X-ray diffraction in operando regime, the microstructural changes in specimen’ subsurface layer during pin-on-disk experiment were studied. Analysis of phase composition showed that formation of martensite side by side with austenite has a cyclic behavior. Besides, it was shown that overall hardening is associated with a set of structural transformations. Finally, the failure of surface layer was observed.