bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bio-Fe3O4 magnetic nanoparticles promoted green synthesis of thioxo-1,3- oxazole derivatives: Study of antimicrobial and antioxidant activity
Authors: Ghazvini Maryam , Sheikholeslami-Farahani Fatemeh , Hamedani Naghmeh Faal , Shahvelayati Ashraf Sadat , Rostami Zohreh 
Published: October 2020

Aims and Objective:
In this work 1,3-oxazoles were generated using multicomponent reaction of α-bromo ketones, alkyl (aryl) isothiocyanates, sodium hydride and Fe3O4 MNPs in water at room temperature in good yields. The nanoparticles that is generated via biosynthesis method have potentially valuable in different purposes such as organic synthesis.

Materials and Methods:
To study antioxidant ability of some synthesized thioxo-1,3-oxazoles, diphenyl-picrylhydrazine
(DPPH) radical trapping and power of ferric reduction testes are employed. Among studied thioxo-1,3-oxazoles, 4b have
good power for radical trapping and reduction activity than to standard antioxidant such as BHT and TBHQ. In addition, the
antimicrobial activity of some thioxo-1,3-oxazoles was studied employing the disk diffusion test on Gram-positive bacteria
and Gram-negative bacteria. The results of disk diffusion test showed that compound 4a, 4b, 4d and 4f prevented the bacterial growth.

Results:
Without employing catalyst, these reactions have low yield and busy mixture. The synthesis of compound 4a as
sample reaction have alike yield in the presence of ZnO-NPs and Fe3O4 MNPs (entry 20 and entry 30) but removal of catalyst from the mixture of reaction after completing of reaction is comfortable in present of Fe3O4 MNPs. Structures of 4a–4i
are confirmed by IR, 1H NMR, 13C NMR mass spectra.

Conclusion:
The reaction of α-bromo ketones, isothiocyanate and sodium hydride in the presence of catalytic amount of
Fe3O4 MNPs in water generate 1,3-oxazole derivatives in good yields. Some advantages of performing these reactions with
present procedure are carrying out these reactions in water as green solvent and simple removal of catalyst.
Physical and Rheological Properties of Poly-floral Honey from the Iraqi Kurdistan Region and the Effect of Temperature on its Viscosity
Authors: Azawy Auday K. , Ibrahim Kocher J. , Abdullah Omed Gh. , Othman Beshroo A. , Al-Saadi Jasim M.S. 
Published: October 2020

Aims:
In this study, the physical and rheological properties of three poly-floral honey
samples collected from different places in the Kurdistan region were determined.

Methods:
The honey samples were analyzed for pH, free acidity, total ash content, moisture content,
refractive index, soluble solids (Brix), electrical conductivity, volume expansion, density, specific
heat capacity, surface tension, and rheological properties. The pH and free acidity of the honey
samples varied from 4.10 to 4.81 to 30 to 62 mEq/kg, respectively. The total ash content ranged
from 0.166 to 0.408%. The moisture content, soluble solids, and refractive index ranged from
15.60 to 16.60 g/100 g, 83.40 to 84.40, and 1.4998 to 1.5023, respectively. The electrical conductivity
ranged from 40.896 to 44.471 mS/cm. The linear relationship between the electrical conductivity
and the ash content was also calculated in this investigation. The volumetric expansion coefficient
of the honey samples varied from 6.0098x10-4 to 6.69942x10-4 mm3/K. The density ranged
from 1.42125995 to 1.45501137 g/cm3. The specific heat capacity varied from 2448.078 to
2575.004 J/kg.K. The surface tension varied from 0.2178 to 0.2282 N/m. The apparent viscosity
was measured by Brookfield Viscometer, and the dynamic viscosity was measured by HAAKE
Falling Ball Viscometer, after changing the temperature from 293 to 323 K.

Results and Discussion:
The honey samples of lower moisture content showed a greater increase
in their apparent and dynamic viscosities. Arrhenius model was used to describe the effect of temperature
on the honey viscosity. This model was used to determine the activation energy. Other rheological
properties such as kinematic viscosity and fluidity, were also determined.

Conclusion:
All the honey samples behaved as Newtonian fluids in the whole temperature range.
Recent Advances in Miniaturized Microextraction Techniques for the Determination of Bisphenols in Environmental Samples: An Overview of the Last Two Decades
Authors: Tsalbouris Athanasios , Kalogiouri Natasa P. , Samanidou Victoria F. 
Published: October 2020

Background:
Bisphenols are major industrial chemicals that have raised public concern
due to their endocrine disrupting properties and toxicity. Sample preparation is the most critical
step for the determination of bisphenols, especially if the analyst has to deal with environmental
samples which are complex matrices and the co-extraction and co-elution of other relevant compounds
results in the enhancement or suppression of the analyte signal. The need for the precise
determination of bisphenols has signaled the development of effective microextraction techniques
according to the Green Analytical Chemistry (GAC) guidelines.

Objective:
The objective of this review is to gather and discuss all the recent advances in the development
of microextraction techniques such as solid phase extraction (SPE), solid phase microextraction
(SPME), magnetic solid phase microextraction (MSPE), liquid-phase microextraction
(LPME), dispersive liquid-liquid microextraction (DLLME), stir bar sorptive extraction (SBSE),
and matrix solid-phase dispersion (MSPD), that have been successfully applied in the extraction of
bisphenols from environmental matrices.

Conclusion:
The analytical performance of the proposed techniques is critically discussed, highlighting
the potential and the limitations of each method.
Predictive Models of Mortality for Hospitalized Patients With COVID-19: Retrospective Cohort Study
Authors: Wang Taiyao , Paschalidis Aris , Liu Quanying , Liu Yingxia , Yuan Ye , Paschalidis Ioannis Ch 
Published: October 2020

Background
The novel coronavirus SARS-CoV-2 and its associated disease, COVID-19, have caused worldwide disruption, leading countries to take drastic measures to address the progression of the disease. As SARS-CoV-2 continues to spread, hospitals are struggling to allocate resources to patients who are most at risk. In this context, it has become important to develop models that can accurately predict the severity of infection of hospitalized patients to help guide triage, planning, and resource allocation.

Objective
The aim of this study was to develop accurate models to predict the mortality of hospitalized patients with COVID-19 using basic demographics and easily obtainable laboratory data.

Methods
We performed a retrospective study of 375 hospitalized patients with COVID-19 in Wuhan, China. The patients were randomly split into derivation and validation cohorts. Regularized logistic regression and support vector machine classifiers were trained on the derivation cohort, and accuracy metrics (F1 scores) were computed on the validation cohort. Two types of models were developed: the first type used laboratory findings from the entire length of the patient’s hospital stay, and the second type used laboratory findings that were obtained no later than 12 hours after admission. The models were further validated on a multicenter external cohort of 542 patients.

Results
Of the 375 patients with COVID-19, 174 (46.4%) died of the infection. The study cohort was composed of 224/375 men (59.7%) and 151/375 women (40.3%), with a mean age of 58.83 years (SD 16.46). The models developed using data from throughout the patients’ length of stay demonstrated accuracies as high as 97%, whereas the models with admission laboratory variables possessed accuracies of up to 93%. The latter models predicted patient outcomes an average of 11.5 days in advance. Key variables such as lactate dehydrogenase, high-sensitivity C-reactive protein, and percentage of lymphocytes in the blood were indicated by the models. In line with previous studies, age was also found to be an important variable in predicting mortality. In particular, the mean age of patients who survived COVID-19 infection (50.23 years, SD 15.02) was significantly lower than the mean age of patients who died of the infection (68.75 years, SD 11.83; P<.001).

Conclusions
Machine learning models can be successfully employed to accurately predict outcomes of patients with COVID-19. Our models achieved high accuracies and could predict outcomes more than one week in advance; this promising result suggests that these models can be highly useful for resource allocation in hospitals.
Health-Related Quality of Life Improvements in Systemic Lupus Erythematosus Derived from a Digital Therapeutic Plus Tele-Health Coaching Intervention: Randomized Controlled Pilot Trial
Authors: Khan Faiz , Granville Nora , Malkani Raja , Chathampally Yash 
Published: October 2020

Background
Systemic lupus erythematosus (SLE), a systemic autoimmune disease with no known cure, remains poorly understood and patients suffer from many gaps in care. Recent work has suggested that dietary and other lifestyle factors play an important role in triggering and propagating SLE in some susceptible individuals. However, the magnitude of influence of these triggers, how to identify pertinent triggers in individual patients, and whether removing these triggers confers clinical benefit is unknown.

Objective
To demonstrate that a digital therapeutic intervention, utilizing a mobile app that allows self-tracking of dietary, environmental, and lifestyle triggers, paired with telehealth coaching, added to usual care, improves quality of life in patients with SLE compared with usual care alone.

Methods
In this randomized controlled pilot study, adults with SLE were assigned to a 16-week digital therapeutic intervention plus usual care or usual care alone. Primary outcome measures were changes from baseline to 16 weeks on 3 validated health-related quality of life (HRQoL) tools: Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), Brief Pain Inventory-Short Form (BPI-SF), and Lupus Quality of Life (LupusQoL).

Results
A total of 50 patients were randomized (23 control, 27 intervention). In per-protocol analysis, the intervention group achieved significantly greater improvement than the control group in 9 of 11 domains: FACIT-F (34% absolute improvement for the intervention group vs –1% for the control group, P<.001), BPI-SF-Pain Interference (25% vs 0%, P=.02), LupusQoL-Planning (17% vs 0%, P=.004), LupusQoL-Pain (13% vs 0%, P=.004), LupusQoL-Emotional Health (21% vs 4%, P=.02), and LupusQoL-Fatigue (38% vs 13%, P<.001) were significant when controlling for multiple comparisons; BPI-SF-Pain Severity (13% vs –6%, P=.049), LupusQoL-Physical Health (17% vs 3%, P=.049), and LupusQoL-Burden to Others (33% vs 4%, P=.04) were significant at an unadjusted 5% significance level.

Conclusions
A digital therapeutic intervention that pairs self-tracking with telehealth coaching to identify and remove dietary, environmental, and lifestyle symptom triggers resulted in statistically significant, clinically meaningful improvements in HRQoL when added to usual care in patients with SLE.

Trial Registration
ClinicalTrials.gov NCT03426384; https://clinicaltrials.gov/ct2/show/NCT03426384
ADAPTATION OF PILOTS AND TECHNICAL ENGINEERING PERSONNEL IN CLIMATE AND GEOGRAPHIC CONDITIONS OF THE FAR NORTH
Authors: Zagorodnikov G. G. , Zhekalov A. N. , Zagorodnikov G. N. , Agaphonov P. V. 
Published: October 2020

The aim of the study:to determine the dynamics of a functional state of the body of pilots and the engineering technical staff in the course of military occupational adaptation to new climatic conditions.Materials and methods.The study enrolled military men aged 24–38 who were split into two groups: the first group (n=34) — the flight personnel, the second group — the engineering technical staff. The course of survey was divided into 3 phases.Results and discussion.For the duration of follow-up, the control group showed increasing of indices of heart rate, cardiac output, double product and circulatory efficiency in comparison with the flight personnel group. In the first group, adaptation disorders were manifested with reducing scope allocation of attention as well as increasing index of instability of simple sensomotor reaction to photic stimulation.
Hubungan Pengetahuan, Sikap, dan Tindakan terhadap DBD dengan Keberadaan Jentik	di Lingkungan Rumah Masyarakat Kecamatan Medan Marelan Tahun 2018
Authors: Simaremare Ade Pryta , Simanjuntak Novita Hasiani , Simorangkir Saharnauli J. V. 
Published: October 2020

Abstract
Dengue Hemorrhagic Fever (DHF) is public health problem in Indonesia and causes extraordinary event with high mortality rate. It is caused by Dengue virus infection of the genus Flavivirirus transmitted by Aedes aegypti bite. All regions in Indonesia are risky for contracting DHF because the virus and the mosquitoes have spread widely in residential housing and public places throughout Indonesia. This study used an observational analytic design with cross sectional method. The respondents were people in the Marelan District of Medan. Data on knowledge, attitudes and practices about DHF were obtained through a guided questionnaire. Data about the presence of Aedes aegypti larvae were obtained through direct observation of the environment around the respondent's houses. The chi square analysis showed that the level of knowledge about DHF was not related to the presence of larvae with a p value of 0.128 (p value> 0.05). For attitude and practice aspects indicate relationship with p values of 0.01 and 0.004 (p value< 0.05). Often the knowledge about DHF is not manifested as action to reduce the presence of mosquito larvae causing the disease in their environment. Still, guidance in intensive counseling and motivating the community about eradicating mosquito nests is very important.
Abstrak
Demam Berdarah Dengue (DBD) merupakan masalah kesehatan masyarakat di Indonesia dan sering menimbulkan kejadian luar biasa dengan tingkat kematian yang tinggi. Penyakit ini disebabkan oleh infeksi virus Dengue dari genus Flavivirus yang dapat masuk ke dalam tubuh manusia melalui perantaraan nyamuk Aedes aegypti. Seluruh wilayah di Indonesia berisiko terjangkit penyakit DBD, sebab baik virus penyebab maupun nyamuk penularnya sudah tersebar luas di perumahan penduduk maupun di tempat-tempat umum di seluruh Indonesia. Penelitian ini menggunakan disain penelitian analitik observasional dengan metode cross sectional. Responden dalam penelitian ini adalah masyarakat di Kecamatan Medan Marelan. Data variabel pengetahuan, sikap dan tindakan mengenai DBD diperoleh melalui kuesioner secara terpimpin. Data variabel keberadaan jentik nyamuk Aedes aegypti diperoleh melalui observasi secara langsung lingkungan sekitar rumah responden. Hasil analisis chi square menunjukkan bahwa tingkat pengetahuan mengenai penyakit DBD tidak berhubungan dengan keberadaan jentik dengan nilai p=0,128 (p value >0,05). Untuk aspek sikap dan tindakan menunjukkan adanya hubungan dengan nilai p masing-masing 0,01 dan 0,004 (p value <0,05). Seringkali pengetahuan mengenai DBD tidak diwujudnyatakan menjadi suatu tindakan untuk mengurangi keberadaan jentik nyamuk penyebab penyakit tersebut di lingkungan rumahnya. Walaupun demikian,pembinaan dalam penyuluhan dan motivasi yang intensif kepada masyarakat tentang pemberantasan sarang nyamuk tetap sangat penting dilakukan.
DETEKSI VIRUS JAPANESE ENCEPHALITIS PADA MANUSIA DAN VEKTOR DI KABUPATEN TULUNGAGUNG, JAWA TIMUR
Authors: Pramestuti Nova , Wijayanti Tri , Widiastuti Dyah , Isnani Tri 
Published: October 2020

Japanese encephalitis is a zoonotic disease transmitted by mosquitoes with pigs as the main reservoir. A small percentage of infected people experience acute encephalitis syndrome, with one in four cases fatal. Recently, the existence of a growing pig population has the potential to increase the risk of JE transmission in Tulung Agung, East Java, Indonesia. The purpose of this study was to detect JE infection in humans and mosquitoes in Tulungagung Regency. A cross-sectional design was conducted from March to October 2016. Human blood screening was carried out in six hospitals in Tulungagung and the mosquitos survey was carried out using human landing collection, resting collection, and light trap around the pig farms in Kaliwungu District. Detection of JE infection was carried out by indirect immuno-linked immunosorbent assay (ELISA) testing of IgM/IgG in human serum samples and Polymerase Chain Reaction (RT-PCR). Transcription reaction in mosquitoes. The ELISA test showed that one of 19 human serum samples was confirmed positive with JE specific IgG. The result of the mosquito survey showed that Anopheles vagus was predominantly collected in Kaliwungu village, while Culex quinquefasciatus was was predominantly species collected in Pulosari Village. The analyses using molecular assays showed that all captured mosquitoes were negative Javanese encephalitis virus (JEV).
Abstrak
Japanese Encephalitis (JE) merupakan penyakit zoonotik yang ditularkan oleh nyamuk dengan reservoir utama babi. Sebagian kecil orang yang terinfeksi mengalami radang otak (ensefalitis), sekitar satu dari empat kasus berakibat fatal. Peningkatan populasi ternak babi di Kabupaten Tulungagung berpotensi menyebarkan virus JE. Tujuan penelitian untuk mendeteksi infeksi JE pada manusia dan nyamuk di Kabupaten Tulungagung. Penelitian dilakukan pada Bulan Maret-Oktober tahun 2016 dengan desain studi potong lintang. Survey darah manusia dilakukan pada enam rumah sakit di Kabupaten Tulungagung. Survei nyamuk dilakukan satu kali dengan metode umpan badan manusia dan perangkap cahaya, serta penangkapan nyamuk istirahat di sekitar peternakan babi di Kecamatan Kaliwungu. Deteksi infeksi JE dilakukan dengan pemeriksaan Indirect Enzyme-Linked Immunosorbent Assay (ELISA) IgM/IgG pada sampel serum manusia dan Reverse Transcription Polymerase Chain Reaction (RT-PCR) pada nyamuk. Hasil pemeriksaan laboratorium terhadap antibodi IgM/IgG JE menunjukkan satu kasus positif IgG JE dari 19 sampel serum manusia yang diperiksa. Spesies nyamuk yang tertangkap di Desa Kaliwungu didominasi Anopheles vagus, sedangkan di Desa Pulosari didominasi Culex quinquefasciatus. Hasil pemeriksaan RT-PCR terhadap semua sampel nyamuk yang tertangkap menunjukkan negatif virus JE. Satu pasien ditemukan positif antibodi IgG Japanese encephalitis di Kabupaten Tulungagung.
Interfacial Evaluation of CAD/CAM Resin Inlays on the Cavity Floor Using Swept-source Optical Coherence Tomography
Authors: Han S-H , Shimada Y , Sadr A , Tagami J , Yang S-E 
Published: October 2020

Clinical Relevance
When a resin nanoceramic inlay is cemented using self-adhesive cement, a universal dentin adhesive can be applied to the prepared cavity. The application of the adhesive before self-adhesive cement placement provides similar or better interfacial adaptation than without the adhesive.

SUMMARY
Purpose: The first objective of this study was to determine whether the luting material used for computer-aided design and computer-aided manufacture resin nanoceramic inlays affected interfacial adaptation. The second objective was to investigate whether application of a universal dentin adhesive before cementation affected interfacial adaptation. The final objective was to compare the inlay-side and dentin-side interfaces in the cement space.
Methods and Materials: Seventy-four class I cavities were prepared on extracted human third molars. Cavities were optically scanned, and resin nanoceramic inlays were milled using Lava Ultimate blocks (3M ESPE). For the control groups, the fabricated inlays were cemented using Panavia V5 (Kuraray Noritake) or FujiCem 2 (GC). For the experimental groups, the teeth were randomly divided into groups I and II. Group I contained four subgroups using different luting materials; in all subgroups, the inlays were cemented and dual cured without pretreatment. Group II contained six subgroups in which inlays were cemented and dual cured after application of a universal dentin adhesive. After thermocycling, interfacial adaptation was measured using swept-source optical coherence tomography (SS-OCT) imaging and statistically compared among groups.
Results: Interfacial adaptation was different depending on the luting material used (p&lt;0.05). After application of a universal adhesive, some subgroups showed improved interfacial adaptation (p&lt;0.05). In the comparison of inlay-side and dentin-side interfaces, no difference was found in interfacial adaptation (p&gt;0.05).
Conclusions: Interfacial adaptation for resin nanoceramic inlays differed with luting material. For some self-adhesive cements, application of a universal adhesive before cementation improved interfacial adaptation.
Maximizing the Implementation of Scientific Approach in History Lessons Through Student-Centered Learning Model
Authors: Ratnasari Novika , Kurniawati Kurniawati , Syukur Abdul 
Published: October 2020

Curriculum changes and developments occur along with the development of educational theory and technological developments. These changes aim to improve the quality of education of Indonesia's human resources. The 2013 curriculum emphasizes the learning process using a scientific approach. The purpose of this study was to analyze the scientific approach in the 2013 curriculum in the implementation of history learning. The type of research used was a qualitative approach. This research was conducted at SMA Negeri 1 Babat Toman Musi Banyuasin. In this study, data were collected using observation, interviews, and document study method. Descriptive data analysis was used in this study. The results of this study indicate that the implementation of history learning in 2013 curriculum that uses a scientific approach through the Student-Centered Learning model and authentic assessment with 5 M (observing, asking questions, collecting data, associating, communicating) maximize learning by following the 2013 curriculum development. This study as a reference material to maximize other subject in accordance with 2013 curriculum development.
Pembuatan Iklan Promosi Perpustakaan Padang Panjang untuk Anak Melalui Media Motion Graphic
Authors: Wilhelmina Grace , Ardoni Ardoni 
Published: October 2020

AbstractThis article discusses the making of Padang Panjang library promotion advertisement for children through motion graphic media. The purpose of writing describes the making of motion graphics to introduce to children. There are 6 stages of making motion graphic as follows: (1) concept or concept, is the stage before making motion graphic, (2) drawing or design, is the stage of making motion graphic more specifically visualized in the form of images, (3) Collection of material or material collecting, is a collection of material in the making of motion graphics, (4) assemblies or assemblies, which are made in several stages, namely designing, animating, compositing, and rendering carried out by using applications, (5) testing or testing the video made, (6) distribution or distribution, is the final stage of packaging and distribution of the product.Keywords: children; library; motion graphic.