bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of zerumbone on scopolamine‐induced memory impairment and anxiety‐like behaviours in rats
Authors: Jafarian Sahba , Ling King‐Hwa , Hassan Zurina , Perimal‐Lewis Lua , Sulaiman Mohd Roslan , Perimal Enoch Kumar 
Published: October 2019

AbstractIntroductionWe investigated the effects of zerumbone (1 and 10 mg/kg) against hyperactivity, anxiety and memory impairment in scopolamine‐induced dementia in Sprague‐Dawley rats.MethodsOpen field tests, elevated plus maze and Morris water maze were performed to assess general locomotor activity, anxiety‐like behaviours and learning and memory processes respectively in rats pretreated with scopolamine.ResultsScopolamine‐treated rats showed high total activity, stereotype, and total distance travelled in the open field arena, reduced number of entries to open arms, decreased the percentage of time spent in open arms and higher escape latency time in the Morris water maze test. Interestingly, single administration of zerumbone (1 and 10 mg/kg) reversed the hyperactivity, anxiety‐like behaviours, and learning impairment effects of scopolamine in the three experimental model studied respectively.DiscussionOur findings demonstrated that the scopolamine‐induced impairment of learning and memory was reversed by the administration of zerumbone. As a conclusion, our findings presented the positive effects of zerumbone on dementia‐like behaviours in the animal model used and could possibly contribute for future research to manage hyperactivity, anxiety, and learning disabilities.
How to Use Replication Assignments for Teaching Integrity in Empirical Archaeology
Authors: Marwick Ben , Wang Li-Ying , Robinson Ryan , Loiselle Hope 
Published: October 2019

ABSTRACTThe value of new archaeological knowledge is strongly determined by how credible it is, and a key measure of scientific credibility is how replicable new results are. However, few archaeologists learn the skills necessary to conduct replication as part of their training. This means there is a gap between the ideals of archaeological science and the skills we teach future researchers. Here we argue for replications as a core type of class assignment in archaeology courses to close this gap and establish a culture of replication and reproducibility. We review replication assignments in other fields and describe how to implement a replication assignment suitable for many types of archaeology programs. We describe our experience with replication in an upper-level undergraduate class on stone artifact analysis. Replication assignments can help archaeology programs give students the skills that enable transparent and reproducible research.
Ice-sheet scale distribution and morphometry of triangular-shaped hummocks (murtoos): a subglacial landform produced during rapid retreat of the Scandinavian Ice Sheet
Authors: Ojala Antti E. K. , Peterson Gustaf , Mäkinen Joni , Johnson Mark D. , Kajuutti Kari , Palmu Jukka-Pekka , Ahokangas Elina , Öhrling Christian 
Published: October 2019

AbstractHigh-resolution digital elevation models of Finland and Sweden based on LiDAR (Light Detection and Ranging) reveal subglacial landforms in great detail. We describe the ice-sheet scale distribution and morphometric characteristics of a glacial landform that is distinctive in morphology and occurs commonly in the central parts of the former Scandinavian Ice Sheet, especially up-ice of the Younger Dryas end moraine zone. We refer to these triangular or V-shaped landforms as murtoos (singular, ‘murtoo’). Murtoos are typically 30–200 m in length and 30–200 m in width with a relief of commonly <5 m. Murtoos have straight and steep edges, a triangular tip oriented parallel to ice-flow direction, and an asymmetric longitudinal profile with a shorter, but steeper down-ice slope. The spatial distribution of murtoos and their geomorphic relation to other landforms indicate that they formed subglacially during times of climate warming and rapid retreat of the Scandinavian Ice Sheet when large amounts of meltwater were delivered to the bed. Murtoos are formed under warm-based ice and may be associated with a non-channelized subglacial hydraulic system that evacuated large discharges of subglacial water.
Breaking the Privacy Paradox: The Value of Privacy and Associated Duty of Firms
Authors: Martin Kirsten 
Published: October 2019

ABSTRACT:The oft-cited privacy paradox is the perceived disconnect between individuals’ stated privacy expectations, as captured in surveys, and consumer market behavior in going online: individuals purport to value privacy yet still disclose information to firms. The goal of this paper is to empirically examine the conceptualization of privacy postdisclosure assumed in the privacy paradox. Contrary to the privacy paradox, the results here suggest consumers retain strong privacy expectations even after disclosing information. Privacy violations are valued akin to security violations in creating distrust in firms and in consumer (un)willingness to engage with firms. This paper broadens the scope of corporate responsibility to suggest firms have a positive obligation to identify reasonable expectations of privacy of consumers. In addition, research perpetuating the privacy paradox, through the mistaken framing of disclosure as proof of anti-privacy behavior, gives license to firms to act contrary to the interests of consumers.
What Is a Pain in a Body Part?
Authors: Aydede Murat 
Published: October 2019

AbstractThe International Association for the Study of Pain’s (IASP) definition of “pain” defines it as a subjective experience. The Note accompanying the definition emphasizes that, as such, pains are not to be identified with objective conditions of body parts (such as actual or potential tissue damage). Nevertheless, it goes on to state that a pain “is unquestionably a sensation in a part or parts of the body, but it is also always unpleasant and therefore also an emotional experience.” This generates a puzzle that philosophers have been well familiar with: how to understand our utterances and judgments attributing pain to body parts. (The puzzle is, of course, general extending to all sensations routinely located in body parts.) This work tackles this puzzle. I go over various options specifying the truth-conditions for pain-attributing judgments and, at the end, make my own recommendation which is an adverbialist, qualia-friendly proposal with completely naturalistic credentials that is also compatible with forms of weak intentionalism. The results are generalizable to other bodily sensations and can be used to illustrate, quite generally, the viability of a qualia-friendly adverbialist (but naturalist and weakly intentionalist) account of perception.
What Is Novel in Hegel'sPhenomenology of Spirit
Authors: Barba-Kay Antón 
Published: October 2019

AbstractWhile it has long been commonplace to advert to thePhenomenology of Spirit's peculiar prosaic form, there has been no sustained, thematic attempt to understand the relationship between that form—as a continuous, quasi-fictional narrative—and the work's philosophical content. I argue that some of what has been felt to be outlandish about the form may be better accounted for by reading it as connected to purposeful literary decisions, decisions in turn exhibiting philosophical claims about the new mode of modern self-understanding that the argument is concerned with advancing. Extending Allen Speight's suggestions that Hegel sees literature as closely connected to his theory of agency, I argue that thePhenomenology's narrative should be understood as itself specifically and deliberately novelesque. I focus on three points that help clarify the book's form as not simply in keeping with, but as expressing aspects of its content: (1) the narrative structure of consciousness (as a unified, unfolding activity through which Hegel explores the notion of actuality), (2) the theatricalizing counterpoint between the ‘in itself’ and ‘for itself’ (as a dramatic device that Hegel connects to the social underpinnings of consciousness), and (3) the role of confession and forgiveness in the argument (as a theme that Schlegel had singled out as essential to the novel, and that Hegel repurposes both to criticize and to overcome Romanticism). I do not say that thePhenomenologyis itself a novel, but that construing some of its formal features and gestures as evoking the genre of the novel can help us to see more of what is philosophically at stake in them, and therefore in the work as a whole.
Modelling a paleo valley glacier network using a hybrid model: an assessment with a Stokes ice flow model
Authors: Imhof Michael A. , Cohen Denis , Seguinot Julien , Aschwanden Andy , Funk Martin , Jouvet Guillaume 
Published: October 2019

AbstractModelling paleo-glacier networks in mountain ranges on the millennial timescales requires ice flow approximations. Hybrid models calculating ice flow by combining vertical shearing (shallow ice approximation) and longitudinal stretching (shallow shelf approximation) have been applied to model paleo-glacier networks on steep terrain, yet their validity has not yet been assessed quantitatively. Moreover, hybrid models consistently yield higher ice thicknesses than Last Glacial Maximum geomorphological reconstructions in the European Alps. Here, we compare results based on the hybrid Parallel Ice Sheet Model (PISM) and the Stokes model Elmer/Ice on the Rhine Glacier, a catchment of the former European Alpine Icefield. For PISM, we also test two magnitudes of flux limitation in a scheme that reduces shearing velocities. We find that the flux limitation typically used in PISM yields significantly reduced shearing speeds and increases ice thicknesses by up to 500 m, partly explaining previous overestimations. However, reducing the ice flux limitation allows the hybrid model to minimize this mismatch and captures sliding speeds, ice thicknesses, ice extent and basal temperatures in close agreement with those obtained with the Stokes model.
‘Our members are growing up!’: contradictions in ageing talk within a lifelong learning institute
Authors: Roberts Summer C. 
Published: October 2019

AbstractWhether encouraging successful ageing or labelling one as a stereotypical senior citizen, messages surrounding ageing pervade the daily lives of older adults. However, as a social status, age remains primarily in the background of older adults’ conversations, only being drawn into the focus when one is identified as older. This paper draws on interviews with members and staff of an Osher Lifelong Learning Institute (OLLI) in the southeastern United States of America in order to examine the ways that they discuss age and ageing. These older adults’ ageing talk often focused on navigating away from negative ideas about age and avoiding labels deemed pejorative. Humour was occasionally used in identifying age, which carried potential for reinforcing as well as subverting ageism. Yet, members highlighted positive value in being older, particularly as demonstrated through participation in age-segregated education. Overall, these findings reflect the conflicting influences of deeply embedded ageist beliefs and personal desires to age successfully among this group of white, upper-middle-class, educated older adults. Ultimately, OLLI served as a protective environment for these privileged individuals, shielding the self from stereotypes otherwise present in ageing talk.
Relationship between primary eradication ofHelicobacter pyloriand drinking habits in women: collaborative research between a pharmacy and a clinic
Authors: Ozeki Kayoko , Asano Michio , Furuta Takahisa , Ojima Toshiyuki 
Published: October 2019

AbstractHelicobacter pyloriis a cause of stomach cancer and peptic ulcer. For prevention, improving the eradication rate ofH. pyloriis crucial. However, the association between eradication and lifestyle of infected patients, including alcohol consumption, remains unclear. We explored associations between failed primary eradication therapy and drinking status by sex. This study involved 356 patients who visited a pharmacy with prescriptions for primaryH. pylorieradication therapy. We assessed drinking habits using a questionnaire. Data on patients with failed primary eradication were provided by the nearby local clinic. We performed logistic regression analysis to examine the effect of drinking habit and frequency of drinking on failed primary eradication by sex. The odds ratio of primary eradication failure in female patients with a drinking habit was 3.75 (P= 0.001), but that in male patients was not significant. The odds ratio tended to increase in relation to drinking frequency in women. Frequent consumption of alcohol is not only likely to affect eradication, but also has a large impact on the bodies of women, who are more susceptible than men to the effects of alcohol. Thus, women should take greater care in alcohol consumption.
Schizophrenia–schizoaffective–bipolar spectra: an epistemological perspective
Authors: Gama Marques João , Ouakinin Sílvia 
Published: October 2019

AbstractFor decades clinicians and researchers have been thinking and writing about the spectrum of schizophrenia disorders. Indeed both Kraepelin and Bleuler believed in schizophrenia as a spectrum, both in a clinical (individual) and hereditary (family) continuum, from just some exquisite personality traits to unquestionable chronic and debilitating psychosis. Other authors would put the schizophrenia spectrum disorders on different levels of continuum: developmental, psychofunctional, existential, and genetic. Here, we would like to present an historical chronology for the schizophrenia–schizoaffective–bipolar spectra plus a tridimensional model for these spectra: the first axis for categories (affective versus nonaffective psychoses), the second axis for dimensions (personality versus full blown psychosis), and a third axis for biomarkers (remission versus relapse). We believe that without the schizophrenia–schizoaffective–bipolar spectra concept in our minds all our efforts will keep failing one the hardest quest: searching for biomarkers in schizophrenia and related disorders.
And If the Opponents of Gender Ideology Are Right? Gender Politics, Europeanization, and the Democratic Deficit
Authors: Rawłuszko Marta 
Published: October 2019

AbstractThis article explores the dynamics of antigender mobilization in Poland and shows how gender equality projects are interconnected with the rise of opponents of “gender ideology.” It highlights material and discursive links between the local implementation of gender mainstreaming and the antigenderist backlash. The article points out that particular gender equality policies in non-Western settings result from Europeanization and thus are marked by a significant democratic deficit—that is, they are promoted without engaging a wider audience and elude parliamentary control. The study shows that if gender equality projects, such as gender mainstreaming, are fostered by external international commitments and obscure bureaucratic measures, they may unintentionally provide the impetus for antigender mobilization. Indeed, gender wars are fueled not only by controversies over gender and LGBT equality but also by growing concerns about citizens’ control over the state and its policies. The article is data based, and by employing framing analysis, it provides an explanation of the recent political success of antigenderist campaigns, which take place in a world of reconfigured states and diminishing democracies.
Discovery Rights and the Arctic
Authors: Schwartz Daniel 
Published: October 2019

AbstractThis article examines whether discovery could, contrary to common philosophical opinion, be taken seriously as a ground of territorial rights. I focus on the discovery of uninhabitable lands such as found in the Arctic. After surveying the role of discovery in Roman private law and modern international law, I turn to Locke's well-known theory or original acquisition. I argue that many of the justifications that do the work in Locke's theory also apply to discovery. I then discuss some of the many reasons why discovery may seem unpromising as a ground of original acquisition. I close by arguing that if there is a bridge mechanism by which property can legitimately transform into territory and if, at least in some circumstances, discovery can produce property rights, then it would follow that in some circumstances discovery could also produce territorial rights.
Riboflavin deficiency alters cholesterol homeostasis partly by	reducing apolipoprotein B100 synthesis in HepG2 cells
Authors: Xin Zhonghao , Bian Xiangyu , Gao Weina , Wang Yawen , Yao Zhanxin , Shi Tala , Guo Changjiang 
Published: October 2019

Abstract. Riboflavin deficiency led to lower blood cholesterol level and higher content of hepatic cholesterol in rats and the mechanisms are not clarified yet. We hypothesized that riboflavin deficiency might alter cholesterol homeostasis via apolipoprotein B100, one of the important proteins in cholesterol transport. To test this hypothesis, HepG2 cells were cultured in riboflavin-deficient media for 4 days to develop riboflavin deficiency. Compared to riboflavin-sufficient cells, the mRNA (0. 37 ± 0.04 vs 1.03 ± 0.29 relative expression level, n = 3) and protein expressions of apolipoprotein B100 (intracellular: 173.7 ± 14.4 vs 254.8 ± 47.2 μg/mg protein; extracellular: 93.8 ± 31.1 vs 161.6 ± 23.9 μg/mg protein; n = 3) were significantly reduced in riboflavin-deficient cells ( P < 0.05). Endoplasmic reticulum oxidoreductin 1 and protein disulfide isomerase, two enzymes involved in the oxidative folding of apolipoprotein B100, were also lower remarkably in expression at both mRNA and protein levels. Meanwhile, intracellular cholesterol was increased (256.3 ± 17.1 μM/g protein vs 181.4 ± 23.9 μM/g protein, n = 4) and extracellular cholesterol decreased (110.0 ± 23.2 μM/g protein vs 166.2 ± 34.6 μM/g protein, n = 4) significantly in riboflavin-deficient cells ( P < 0.05). Very low-density lipoprotein was also diminished (29.0 ± 6.1 μM/g protein vs 67.0 ± 11.0 μM/g protein, n = 4) in the culture media ( P < 0.05). These findings suggest that riboflavin deficiency alters cholesterol homeostasis partly by reducing apolipoprotein B100 synthesis in HepG2 cells.
Reassessing Southern Ocean Air‐Sea CO2 Flux Estimates With the Addition of Biogeochemical Float Observations
Authors: Bushinsky Seth M. , Landschützer Peter , Rödenbeck Christian , Gray Alison R. , Baker David , Mazloff Matthew R. , Resplandy Laure , Johnson Kenneth S. , Sarmiento Jorge L. 
Published: October 2019

AbstractNew estimates of pCO2 from profiling floats deployed by the Southern Ocean Carbon and Climate Observations and Modeling (SOCCOM) project have demonstrated the importance of wintertime outgassing south of the Polar Front, challenging the accepted magnitude of Southern Ocean carbon uptake (Gray et al., 2018, https://doi:10.1029/2018GL078013). Here, we put 3.5 years of SOCCOM observations into broader context with the global surface carbon dioxide database (Surface Ocean CO2 Atlas, SOCAT) by using the two interpolation methods currently used to assess the ocean models in the Global Carbon Budget (Le Quéré et al., 2018, https://doi:10.5194/essd‐10‐2141‐2018) to create a ship‐only, a float‐weighted, and a combined estimate of Southern Ocean carbon fluxes (<35°S). In our ship‐only estimate, we calculate a mean uptake of −1.14 ± 0.19 Pg C/yr for 2015–2017, consistent with prior studies. The float‐weighted estimate yields a significantly lower Southern Ocean uptake of −0.35 ± 0.19 Pg C/yr. Subsampling of high‐resolution ocean biogeochemical process models indicates that some of the differences between float and ship‐only estimates of the Southern Ocean carbon flux can be explained by spatial and temporal sampling differences. The combined ship and float estimate minimizes the root‐mean‐square pCO2 difference between the mapped product and both data sets, giving a new Southern Ocean uptake of −0.75 ± 0.22 Pg C/yr, though with uncertainties that overlap the ship‐only estimate. An atmospheric inversion reveals that a shift of this magnitude in the contemporary Southern Ocean carbon flux must be compensated for by ocean or land sinks within the Southern Hemisphere.
Satellite Data‐Based 3‐D Simulation of Kelvin‐Helmholtz Instability and Induced Magnetic Reconnection at the Earth's Magnetopause
Authors: Sisti M. , Faganello M. , Califano F. , Lavraud B. 
Published: October 2019

AbstractWe present a 3‐D two‐fluid simulation using plasma parameters as measured by MMS on 8 September 2015 concerning the nonlinear development of the Kelvin‐Helmholtz instability at the Earth's magnetopause. We observe an extremely rich nonlinear dynamics including the development of a complex magnetic topology, vortex merging, and secondary Kelvin‐Helmholtz instability driven by large‐scale vortices distributed asymmetrically in latitude. Vortex induced and midlatitude magnetic reconnection coexist and produce an asymmetric distribution of magnetic reconnection events. These results are in good agreement with MMS observations on the same day, in particular for the presence of both equatorial and off‐equator reconnection. Regarding the latter only, we note a predominance of reconnection in the Southern Hemisphere during the early nonlinear phase. The estimated effective diffusion coefficient associated with the dynamics is found to be large enough to account for the observed mass transport at the Earth's magnetospheric flanks.
Vortex‐Wide Detection of Large Aspherical NAT Particles in the Arctic Winter 2011/12 Stratosphere
Authors: Woiwode W. , Höpfner M. , Bi L. , Khosrawi F. , Santee M. L. 
Published: October 2019

AbstractMicron‐sized HNO3‐containing particles in polar stratospheric clouds are known to denitrify the polar winter stratosphere and support chemical ozone loss. We show that populations of nitric acid trihydrate (NAT) particles with volume‐equivalent median radii of 3–7 μm can be detected vortex‐wide by means of infrared limb sounding. Key for detection are the applied optical characteristics of highly aspherical particles consisting of the β‐NAT phase. Spectroscopic signatures and ambient conditions of detected populations show that these particles play a key role in denitrification of the Arctic winter stratosphere. Complementary gas‐phase HNO3 observations indicate collocated highly efficient HNO3 sequestration within days and are consistent with measured spectral signals of populations of large NAT particles. High amounts of condensed gas‐phase equivalent HNO3 exceeding 10 ppbv and long persistence of detected populations, despite expected gravitational settling, imply that our understanding of the particles is incomplete.