bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of red cell alloantibodies in thalassaemia patients
Authors: Sahu Ansuman , Parida Pankaj , Mahapatra Smita , Sahoo Binay Bhusan 
Published: January 2020

Background: β-thalassaemia patients receive regular blood transfusion to thrive. Due to antigen disparity between the blood donors and these patients they develop red cell alloantibodies due to alloimmunization. The objective of this study is to predict the frequency of red cell alloimmunization amongst β-thalassaemia major patients receiving regular blood transfusion.Methods: This study including 106 patients with β-thalassaemia was conducted in the department of Transfusion Medicine, S. C. B. Medical College, Cuttack for a period of 12 months. Alloantibodies to different red cell blood group antigens in multi-transfused thalassaemia patients were detected using the glass bead technology for blood group serology in the present study.Results: Out of 106 β-thalassaemia major patients included in the study, 7.5% of patients developed alloantibodies, all being clinically significant. The alloantibodies were anti-E, anti c, anti e and anti-D. The rate of incidence of these alloantibodies was 3.8%, 1.9%, 0.9% and 0.9% respectively. There was a significant association between alloantibody formation with number of transfused packed red cells (Mann-Whitney Test: p value = 0.035) and age at first transfusion (p value = 0.001). The factors having no association with alloimmunization to red cell antigens are age and gender.Conclusions: Alloimmunization to various erythrocyte blood group antigens is a common problem in multi-transfused β-thalassaemia patients. There is an association between number of transfused packed red cells and age at first transfusion with alloantibody formation in the study.
Parents perception on pattern and effects of usage of electronic devices among school going children
Authors: Kuriakose Roshan , N. Prasad Nayak , Saldanha Prakash 
Published: January 2020

Background: Over usage of electronic gadgets has a serious impact on physical activity of children leading to obesity, depression, anxiety, poor scholastic performance, strain on the eyes and triggering factor for neck and back pain (due to spondylitis).It is very important to know how to control the screen time of children by parents.Methods: Here, 75 parents were subjected to questionnaire study which contained questions on the information on usage of electronic devices among children and the adverse effects noticed. Results were analyzed using Microsoft excel software.Results: Almost all the 75 cases had access to television, 64 had access to smart phones, 24 had access to IPAD/Tablet, 8 had access to laptop and 4 had access to gaming console. It was found that 45 % were depressed / anxious when gadgets were withdrawn from them. 21 kids had no idea what to do when gadgets were not available. 54 kids had no interest in outdoor playing and 38 children were found to have decreased interaction with other family members.Conclusions: Exposure to gadgets in paediatrics population leads to poor scholastic performance, obesity, depression, decreased interaction with family and many other problems. So, it is very important to have control on child’s day to day activities and have constant vigilance on their gadget usage.
Screening and quantitative estimation of factor VIII inhibitors by Nijmegen-Bethesda assay in hemophilia a patient of Southern Odisha, India
Authors: Nayak Jayanti , Kar Sonali , Kar Monali 
Published: January 2020

Background: The current treatment of haemophilia is replacement of factor VIII or IX which is effective till development of inhibitor against factors. There has been no study on factor VIII inhibitors in Southern Odisha using Nijmegen–Bethesda assay. This study was planned with objectives to screen factor VIII inhibitors in hemophilia-A patients, to do quantitative estimation of it using Nijmegen-Bethesda assay and to explore factors associated with development of inhibitors. Methods: This cross-sectional study was carried out from September 2016 to August 2018 in Department of pathology, MKCG medical college, Berhampur. Haemophilia-A patients coming to MKCG medical college and registered Haemophilia-A cases under Haemophilia society of Berhampur were included. Patients denying consent and having multiple clotting factors deficiencies were excluded. 1.8ml blood was collected. Mixing study was done to screen factor VIII inhibitors and then in positive cases inhibitors level measured by Nijmegen-Bethesda method. All data were analysed using SPSS (version 16.0).Results: 70 cases of Hemophilia-A patients were studied. Majority (50%) were with severe hemophilia-A. 7 patients developed inhibitors where 3 were high and 4 were low responders. Inhibitor level ranged from 0.8 to 64 Nijmegen-Bethesda units. Patients with severe hemophilia A, more than 10 transfusions and who switched to receive recombinant FVIII from other blood products developed inhibitors which were significant.Conclusions: Severity of hemophilia, increase frequency of transfusion and switching of blood products significantly increases chances of inhibitor development and hence intensive inhibitor screening is needed in these cases. Quantification of inhibitor is needed to monitor treatment and to manage bleeding episodes effectively.
Study of patients with suicidal ideation with sleep disorders and depression in Karnataka population
Authors: Kumar Jayant , R. Rekha 
Published: January 2020

Background: 85, adult patients aged between 17 to 65 years of both sexes were studied with to know the etiology of suicidal ideation.Methods: Applying methodical instruments like sleep habits questionnaires and Black scale for suicidal ideation to rule out etiology and types of suicidal ideation.Results: Total 13(15.2%) had active suicidal ideation, 23(27%) specific plans for suicide 20(23.5%) had passive suicidal ideation, 29(34%) patients had previous history of suicidal attempts. Majority of the patients were under treatment of hypnotics and antidepressants’, 11(12.9%) were on clonozepine 12(14.1%) were on lorazepam 9(10.5%) were on chlordiazepoxide, Antidepressants, 8(9.41%) were on sertalin, 14(16.4%) desvenlafaxine, 15(17.6%) Amitriptyline, 16(18.8%) were on duloxetine.Conclusions: This pragmatic study highlights the suicidal ideation with sleep disorders and depression, will be quite helpful to psychiatrist, psycho-social worker to treat the patients efficiently
Study of serum vitamin D2 and calcium in young and middle aged healthy male smokers in rural tertiary care center
Authors: Paladugu Lalitha , V. Anjaneya P. , Mureboina Jayasree , Tummala Anusha C. 
Published: January 2020

Background: Smoking is an essential determinant of various diseases. The study is aimed to understand the influence of smoking on serum vitamin D2/D3 levels and serum calcium levels in healthy young/middle-aged men.Methods: Prospective observational study was done among young and middle-aged healthy male smokers in a rural territory care center. Two hundred patients were studied and analyzed, who fulfill the inclusion and exclusion criteria.Results: The prevalence of vitamin D deficiency (25(OH)D <20 ng/ml) was 50.3%. Only 8.8% of the participants had vitamin D sufficiency (25 hydroxyvitamin D ≥30 ng/ml). There is a strong correlation between 25(OH)D and smoking in the participants (p<0.001). 25 hydroxyvitamin D level was lower by approximately 4.3 ng/ml (p<0.001) in a smoker compared to a non-smoker among the total participants, this value increased to 9.2 ng/ml in the 40-50y subgroup (p=0.003). A multinomial logistic regression model demonstrated that a young smoker (20-29y) had a 58% increased likelihood of having vitamin D deficiency compared to a non-smoker of the same age group (p=0.041). Irrespective of age and chronicity of smoking, there was a significantly increased level of serum calcium and significant vitamin D2/D3 deficiency in smokers.Conclusion: A high prevalence of vitamin D deficiency was identified in young and middle-aged male smokers, which is not likely to be explained by other confounding lifestyle factors. The depression of the vitamin D-PTH system seen among smokers may represent another potential mechanism for the harmful effects of smoking on the skeleton.
Vitamin D: role of vitamin D in human health beyond skeleton
Authors: Singh Ambrish , Soni Ameet , Changani Mohit , Choksi Harsh 
Published: January 2020

Deficiency of vitamin D is now considered as epidemic in Indian subcontinent, with a prevalence of 70-94% in the general population. Like in US, Indian dairy products are rarely fortified with vitamin D. Socioreligious and cultural practices followed in India do not facilitate adequate sun exposure, thereby negating potential benefits of plentiful sunshine resulting in vitamin D deficiency. Deficiency is highly prevalent in both urban and rural settings. Vitamin D deficiency can lead to rickets, osteoporosis, cardiovascular diseases, diabetes, cancer and infections. In present review authors have revisited the details pertaining to vitamin D to increase the awareness on Vitamin D efficiency.
Assessment and accreditation of a medical college by national assessment and accreditation council: an overview
Authors: Doddaiah Sunilkumar , Bhat Deepa , Hathur Basavanagowdappa , Suma M. N. , V. Manjunath G. , Vishwanath Prashant 
Published: January 2020

Accreditation affirms provision of quality education, thus determines its graduate attributes. WFME, WHO and various bodies have been striving to ensure credibility of educational institutions through accreditation. NAAC is an Indian accrediting body providing framework for quality assurance to higher education institutions. Being an autonomous body under UGC, it sets a standard of excellence to which they are bound to adhere. This article provides details regarding an insight into NAAC, its vision, objectives, core values and the process of accreditation. The details regarding various criteria, components, allotment of weightage to each of them are detailed in the manuscript. The requirements and needs towards preparedness for this accreditation process are simplified to make the readers to understand easily thus providing a bird’s eye view of entire process.
Vaccination coverage of children in tribal Narmada district of Gujarat: a cross sectional study
Authors: Parmar Rahul , Prajapati Nirmal , Shringarpure Kalpita 
Published: January 2020

Background: Vaccination being one of the cheapest and safest methods of primary prevention, indicators of maternal and child healthcare are crucial. Multi-indicator cluster survey was planned to check these objectives as set up in reproductive child health (RCH)-II and National Rural Health Mission (NRHM) plan. This study was initiated to determine the vaccination coverage among the children in tribal district in Gujarat and to determine factors associated with partial immunization and non-immunization.Methods: A community based cross-sectional study was done in tribal district Narmada in Gujarat for a period of four months from May 2011 to August 2011. The study population consisted of all children aged between 12-23 months. After using cluster sampling method, assessment of vaccination programme was obtained from 346 out of total 352 children scattered across 30 clusters. A pre-tested semi-structured questionnaire was administered by interview technique.Results: Highest coverage was seen in the first dose of diphtheria, pertussis, and tetanus (DPT) 95.7% (CI 92.3-99) followed by Bacillus Calmette-Guérin (BCG) 95.4% (CI 92-98.7) and first dose of oral poliovirus vaccines (OPV) 95.4% (CI 92-98.7). The proportion of fully immunized children was 77.7% (CI 69.4-86.1), whereas 2.9% (CI 0.0-6.1) children were not vaccinated at all. The drop-out rate was 8.76% from DPT1 to DPT3 and 16% for DPT1 to measles.Conclusions: Vaccination coverage was highest for DPT first dose followed by BCG. The drop- out rate was 8.76% from DPT1 to DPT3 and 16% for DPT1 to measles. Non-awareness regarding subsequent doses of vaccines was most common reason for partial or non-vaccination.
Prevalence of internet gaming disorder in India: a technological hazard among adolescents
Authors: Undavalli Vamsi Krishna , Rani Gobburi Sudha , Kumar Jonnalagadda Ravi 
Published: January 2020

Background: Internet gaming disorder (IGD) refers to the problematic use of on-line or off-line video games. Presently the prevalence of IGD among the adolescent group was between 1.3% to 19.9% and males reported more prevalence than females. Aims of this study was to know the prevalence and the various factors associated with the development IGD among adolescents.Methods: Settings and Design was to a cross sectional study was conducted among students of High schools for a period of 3 months from July 2018 - September 2018. Four hundred adolescent students were included in the study. English version of the DSM–5 short (9-item) dichotomous scale with cut-off point of five or more criteria was used for diagnosing the IGD.Statistical analysis used descriptive statistics were represented with frequencies and percentages. Chi-square and Fisher Exact tests were applied to find significance difference. P<0.05 was considered as statistically significant.Results: An overall prevalence estimate of IGD was 3.50% among the school children and it is higher among male students (8.8%) than female students (0.8%) and it was found statistically significant with a p value of <0.001.Conclusions: The prevalence differences between Age groups, gender, class of the student and availability of smart phone with internet facility act as an important risk factors for the occurrence of IGD among adolescents.
Evaluation of a replanted finger and measuring its perfusion changes to predict its viability by laser speckle contrast imaging
Authors: Akthar Bilkis , Wang Zeng Tao , Khashru Muhsin Billah Bin , Dian Hou Zhi 
Published: January 2020

<p class="abstract"><strong>Background:</strong> This research aims to monitor the microcirculation of the replanted finger, which was entirely severed by using laser speckle contrast imaging (LSCI) for early detection and revision of vascular compromise for successful finger replantation.</p><p class="abstract"><strong>Methods:</strong> These six months of research was taken for a survey of 40 cases of replanted fingers of patients of distinct ages and sex. Scrutinizing was done postoperatively by LSCI, every hourly for seven days, to assess changes in blood perfusion both in replanted fingers and healthy ones and analyzed graphically. </p><p class="abstract"><strong>Results:</strong> Initially, from postoperative d=0 to d=2, the perfusion value was at baseline, which ranged 40±15 perfusion unit (PU), showing a wave-like curve, then gradually increased up to 350±50 PU or above in case of those which survived successfully, showing continuous peak slope. However, a gradual drop in perfusion, &lt;35 PU from d=2 or d=3, was seen in those despite undergoing heparinized finger pin-prick bleeding therapy and failed to thrive, showing a downslope curve. Whereas some were under meticulous observation, which flourished lately. Concurrently, a comparison was made with the healthy fingers’ of the same patient, ranging from 200±50 to as high as 400±50 or above. Clinical correlation, as well as perfusion readings of LCSI, were done simultaneously.</p><p class="abstract"><strong>Conclusions:</strong> LSCI provides sensitive and reproducible finger microcirculation measurements and is reliable in predicting reductions in blood perfusion induced by venous or arterial occlusion. It is, therefore, an informative device to detect microvascular compromise during and after replantation surgery.</p>
Management of traumatic and non traumatic hollow visceral perforation in North India
Authors: Pal Naresh , Mishra Vineet , Jangra Amit , . Poonam , Jain Udit 
Published: January 2020

<p class="abstract"><strong>Background:</strong> Hollow visceral perforation is the commonest perforation among all the hollow viscera in the body. The perforation can be traumatic or non-traumatic and it constitute commonest surgical emergency worldwide. The diagnosis of perforation can be made clinically but for confirmation basic radiological investigations and sometimes special investigation are required.</p><p class="abstract"><strong>Methods:</strong> This is a prospective observational study conducted in our institute in the Department of General Surgery. The patients who are included in this study were more than 15 years of age in both sexes having hollow visceral perforation presenting in accident and emergency department. </p><p class="abstract"><strong>Results:</strong> Out of 624 patients, 530 (84.93%) were males while only 94 (15.06%) were females, with a male: female ratio of 5.63:1. The site of perforation are ileum 37.01% duodenum, 28.36% maximum sites of hollow viscous perforation. Acid peptic disease was the cause of perforation in 27.40% of 171 cases. Enteric fever accounted maximally for 29% of 181 cases and all in the ileum. Acute appendicitis resulted in perforation of the appendix in 64 cases (10.25%) while blunt trauma abdomen causes perforation in 12.66% of 79 cases. Perforation due to stab injury accounted for 5.12% and fire arm injury perforation seen in 19 patients (3.04%).</p><p><strong>Conclusions:</strong> Early diagnosis of perforation, resuscitation with crystalloids with broad spectrum antibiotic coverage and urgent surgical intervention whenever patient is fit for anaesthesia are the important factors which decides the ultimate fate of the patient in case of hollow visceral perforation peritonitis. </p>
Antibacterial efficacy of black seed honey in combination with penicillin and amoxiclav against gram-positive bacteria
Authors: Hossain Rozely , Rahman M. S. , Rayhan M. A. , Nawrin Kashfia , Billah Mohammad M. , Habib M. R. 
Published: January 2020

<p class="abstract"><strong>Background:</strong> The emergence of antimicrobial resistance possesses a great threat for the existence of mankind. Antibiotics like penicillin and amoxiclav are at the brink of losing their efficacy entirely in exposure to resistant bacteria. Thus, the present study was aimed to find out the antibacterial efficacy of black seed honey as an alternative natural source which can act independently and boost the efficacy of standard drugs alongside.</p><p class="abstract"><strong>Methods:</strong> Penicillin, amoxiclav and black seed honey were first individually trailed against four gram-positive bacteria - <em>Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis </em>and<em> Micrococcus luteus</em>.<strong> </strong>Afterwards, penicillin and amoxiclav were used in combination with honey and compared the synergistic effects with their individual efficacy. Zones of inhibition from well diffusion method, percentage inhibition, minimum inhibitory and bactericidal concentrations by microdilution method were determined in the present study. </p><p class="abstract"><strong>Results:</strong> Black seed honey alone demonstrated great inhibitory potential against <em>S. aureus </em>(9.7 mm), <em>S. epidermidis </em>(9.9 mm) and <em>M. luteus</em> (9.3 mm) in well diffusion method. Moreover, its combination with amoxiclav showed synergistic effect against all bacteria except <em>S. epidermidis</em>. However, its conjugation with penicillin was not able to produce any synergism as exhibited by zones of inhibition. The lowest concentration (1.56%) of honey applied individually or in combination in microdilution method found<strong> </strong>highly effective which established an inverse dose dependent relationship with efficacy.</p><p class="abstract"><strong>Conclusions:</strong> From the data it can be concluded that the black seed honey is a highly potent natural agent which can be utilized in antimicrobial therapy. However, further investigation is recommended to identify the responsible compound for such activity.</p>
Side effects of medications in professional opera singers’ voice: survey findings
Authors: Clarós Pedro , Mikolajczyk Kinga , Pujol Astrid Clarós , Pujol Carmen , Sabater Juan , Clarós Andrés 
Published: January 2020

<p class="abstract"><strong>Background:</strong> Opera singers are classified under level I, as the elite vocal performers, being the quintessential representatives of this group. As the professional voice users, they meticulously observe any changes relevant to their health, therefore self-reported side effects should be taken under serious consideration. The aim of this study was to initiate the process of gathering general information about the most common side effects of medications taken by the opera singers.</p><p class="abstract"><strong>Methods:</strong> The study group consisted of 264 professional opera singers, treated in Clarós Clinic in a 35 years period, who were asked to complete a questionnaire. The response rate was 62.1% (n=164) with a male-to-female ratio being 1.27:1 (72 men and 92 women). 46 cases of adverse effects of medicines were updated and analysed. All the responses were collected between February and April 2018. </p><p class="abstract"><strong>Results:</strong> The mean age of our study group was 38.3 for females and 49.95 for males, with the range between 18-83 years. The vocal categories were as follows: 39 tenors, 17 baritones, 14 basses, 64 sopranos, 23 mezzo-sopranos and 5 contraltos. Patients with chronic diseases and comorbidities represented the 39.1% of the study group. The most common adverse effect reported was dryness (15.2%). The most frequent voice side effects raised by singers were clearing the throat frequently (14.63%), hoarseness and coarse or scratchy sound (10.37%), and vocal fatigue (7.32%).</p><p><strong>Conclusions:</strong> We believe that exploring the subject of vocal side effects of medications in professional opera singers is extremely important.</p>
Laryngo-tracheo-bronchial foreign bodies: epidemiological, diagnostic and therapeutic aspects
Authors: Amana Bathokédéou , Pegbessou Essobozou Plaodezina , Amana Essobiziou , Foma Winga , Dolou Warou , Laws Stephen , Boko Essohanam , Kpemissi Eyawelohn 
Published: January 2020

<p class="abstract"><strong>Background:</strong> The objective of the study was to describe the epidemiological, diagnostic and therapeutic aspects of laryngo-tracheo-bronchial (LTB) foreign bodies (FB).</p><p class="abstract"><strong>Methods:</strong> A 20-year retrospective study, performed in the ENT, head and neck surgery department of Sylvanus Olympio Teaching Hospital in Lomé, dealing with patients treated for this LTB. </p><p class="abstract"><strong>Results:</strong> Sixty-one cases of LTB FB were collected. The LTB FB represented 3.05 cases per year, 11.71% of the FB airways and 4.08% of ENT FB. Thirty-two patients (52.46%) were male, a sex ratio of 1.10. The average age of patients was 5.08 years, with extremes of 4 months and 43 years. In 31 cases (50.82%), the accident occurred during the meal and in 30 cases (49.18%) during a game. The penetration syndrome was found in 54 cases (88.52%). FB was extracted by rigid tube bronchoscopy in 50 patients (81.97%). The most common site of endoscopy was right bronchus in 30 cases (49.18%) and in 11 cases (18.03%) FB was laryngeal. Organic FB accounted for 31 cases (50.82%) and was dominated by peanuts (29.5%), for non-organic FB they were dominated by pebbles (8.2%). The evolution was favorable in 58 cases (95.08%).</p><p class="abstract"><strong>Conclusions:</strong> Severe accidental pathology, the prognosis depends on the nature of the body, its seat and the time of care.</p>