bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avaliação da qualidade de vida e impacto na saúde bucal da pessoa com deficiência visual
Authors: Silva Neta Maria Eugenia da , Barbosa da Silva Maria das Graças , Catão Maria Helena Chaves de Vasconcelos 
Published: December 2020

Objetivo: Avaliar a qualidade de vida (QV) e a percepção da saúde bucal de deficientes visuais. Métodos: Trata-se de um estudo quantitativo, de caráter transversal, abrangendo pessoas com deficiência visual, nos meses de setembro e novembro de 2019. Foram entrevistados 20 deficientes visuais no Instituto de Educação Assistencial aos Cegos do Nordeste, Campina Grande, Paraíba, Brasil, maiores de 18 anos. Para a avaliação da QV foi utilizado o World Health Organization Quality of Life (WHOQOL-Bref) e para avaliação da percepção de saúde bucal foi utilizado o Oral Health Impact, Profile (OHIP-14, versão em português). Para a análise dos dados utilizou-se a estatística descritiva e categorização. Resultados: Observou-se uma predominância de indivíduos do sexo masculino (80%), com média de idade de 32,3 anos. Em relação à escolaridade, 40% possuíam o ensino médio completo. Sobre o estado civil, 75% eram solteiros. O estudo revelou melhor QV nos domínios psicológico e relações sociais (escores médios, EM: 4,0 ± 2,83 e 3,9 ± 3,22, respectivamente). Com relação à avaliação da percepção sobre a saúde bucal, as dimensões mais afetadas foram dor física (EM 2,05 ± 2,01) e desconforto psicológico (EM 2,25 ± 2,27). Conclusão: Pessoas com deficiência visual apresentam uma menor percepção de QV nos domínios físico e de meio ambiente e, no que tange à percepção de saúde bucal, os indivíduos pesquisados sentem-se insatisfeitos com a sua atual condição.
Children and adolescents’ health on focus: Gastrointestinal injuries associated with Helicobacter pylori
Authors: Bertolo Guariento Maria Rossana , Pereira da Silva Janine , Guariento Giovana Bertolo , Pinasco Gustavo Carreiro , Sales Arthur Brunelli , Alves Catarina Bubach Ribeiro , Pimassoni Lucia Helena Sagrillo , Ramos-Silva Valmin 
Published: December 2020

Objective: To describe the prevalence of Helicobacter pylori (HP) in children and adolescents, and to assess its association with lesions in the esophagus, stomach, and duodenum according to the patient’s life cycle. Methodsː A cross-sectional analytical study with children and adolescents referred to a gastroenterology service and underwent esophagogastroduodenoscopy at a hospital in Vitória, Espírito Santo, Brazil, from 2001 to 2013. Variables analyzed were the following: sex, age, macro and microscopic alterations and severity of infestation. The Chi-square and Fisher's exact tests and adjusted residue analysis were used (α = 5%). Resultsː the prevalence of infection was 24.4%. Esophagitis (29.4%) and gastritis (34.1%) were associated with HP. The life cycle was associated with esophagitis and duodenitis. Infection was associated with life cycle: infants (0.8%), preschool children (10.5%), school-aged children (16.5%), and adolescents (72.2%). The residues showed a strong association between HP and gastritis, and no association between the school-aged and esophagitis. Adolescents were the major contributors to the association between life cycle and infection, and life cycle and lesion. Conclusionsː Infection with HP was associated with esophagitis and gastritis and was higher among adolescents, who had a marked tendency to develop gastritis and a milder tendency to develop esophagitis. The tendency of developing infection and gastritis was not present in the other life cycles. Public policies focusing on promotion and protecting health, especially in vulnerable population groups, are needed.
Interferência do comportamento sedentário e da prática de atividade física nos indicativos de burnout de estudantes de educação física
Authors: Oliveira Daniel Vicentini de , Freire Gabriel Lucas Morais , Xavier Jeferson de Jesus Moura , Ribeiro Thiago Becegatto , Pimentel Helcimary Dalila Alves , Gouvêa José Alípio Garcia , Oliveira Leonardo Pestillo de , Nascimento Júnior José Roberto Andrade do 
Published: December 2020

Objetivo: verificar se o comportamento sedentário e a duração e frequência da prática de atividades físicas interferem nos indicativos de burnout de estudantes universitários de educação física. Métodos: trata-se de um estudo transversal, realizado com 147 acadêmicos de educação física, bacharelado, de ambos os sexos. Foi utilizado uma adaptação para o contexto acadêmico (estudantes) do Cuestionario para la Evaluación del Síndrome de Quemarse por el Trabajo, e o Questionário Internacional de Atividade física (IPAQ – versão curta). Os dados foram analisados pelos testes Kolmogorov-Smirnov e “U” de Mann-Whitney e o nível de significância adotado foi de p < 0,05. Resultados: os estudantes que caminham até 40 min por dia apresentaram maiores sintomas de burnout do que os estudantes com maior tempo de caminhada no dia (p = 0,007). Os estudantes que caminham até 135 min semanais apresentaram maiores indicativos para desenvolvimento de desgaste psíquico do que os que caminham mais de 135 min semanais (p = 0,017). Os estudantes que praticam até 60 min de atividades moderadas por dia apresentaram escore superior aos estudantes que praticam mais de 60 min de atividades moderadas por dia (p = 0,011). Foram encontradas diferenças significativas nas dimensões de indolência (p = 0,011) e culpa (p = 0,023), evidenciando que os estudantes que passam mais tempo sentados apresentaram escore superior em ambas as dimensões de burnout. Conclusão: a duração e frequência da atividade física e o comportamento sedentário interferem nos indicativos de burnout em estudantes de educação física.
Development and Feasibility of a Digital Acceptance and Commitment Therapy–Based Intervention for Generalized Anxiety Disorder: Pilot Acceptability Study
Authors: Hemmings Nicola R , Kawadler Jamie M , Whatmough Rachel , Ponzo Sonia , Rossi Alessio , Morelli Davide , Bird Geoffrey , Plans David 
Published: December 2020

Background
Generalized anxiety disorder (GAD) is characterized by excessive worry that is difficult to control and has high comorbidity with mood disorders including depression. Individuals experience long wait times for diagnosis and often face accessibility barriers to treatment. There is a need for a digital solution that is accessible and acceptable to those with GAD.

Objective
This paper aims to describe the development of a digital intervention prototype of acceptance and commitment therapy (ACT) for GAD that sits within an existing well-being app platform, BioBase. A pilot feasibility study evaluating acceptability and usability is conducted in a sample of adults with a diagnosis of GAD, self-referred to the study.

Methods
Phase 1 applied the person-based approach (creation of guiding principles, intervention design objectives, and the key intervention features). In Phase 2 participants received the app-based therapeutic and paired wearable for 2 weeks. Self-report questionnaires were obtained at baseline and posttreatment. The primary outcome was psychological flexibility (Acceptance and Action Questionnaire-II [AAQ-II]) as this is the aim of ACT. Mental well-being (Warwick-Edinburgh Mental Well-being Scale [WEMWBS]) and symptoms of anxiety (7-item Generalized Anxiety Disorder Assessment [GAD-7]) and depression (9-item Patient Health Questionnaire [PHQ-9]) were also assessed. Posttreatment usability was assessed via self-report measures (System Usability Scale [SUS]) in addition to interviews that further explored feasibility of the digital intervention in this sample.

Results
The app-based therapeutic was well received. Of 13 participants, 10 (77%) completed the treatment. Results show a high usability rating (83.5). Participants found the digital intervention to be relevant, useful, and helpful in managing their anxiety. Participants had lower anxiety (d=0.69) and depression (d=0.84) scores at exit, and these differences were significantly different from baseline (P=.03 and .008 for GAD-7 and PHQ-9, respectively). Participants had higher psychological flexibility and well-being scores at exit, although these were not significantly different from baseline (P=.11 and .55 for AAQ-II and WEMWBS, respectively).

Conclusions
This ACT prototype within BioBase is an acceptable and feasible digital intervention in reducing symptoms of anxiety and depression. This study suggests that this intervention warrants a larger feasibility study in adults with GAD.
Percepción del alumnado de Educación Secundaria sobre las personas con discapacidad y el personal de apoyo educativo en las clases de Educación Física
Authors: Garoa Muro Jon , Iturricastillo Urteaga Aitor , Rodriguez-Negro Josune , Castillo Alvira Daniel , Romaratezabala Aldasoro Estibaliz , Yanci Irigoyen Javier 
Published: December 2020

El presente estudio tuvo por objeto conocer la percepción que tienen los estudiantes de Educación Secundaria de las personas con discapacidad, de las relaciones que mantienen con ellas en las clases de Educación Física y del papel que desempeña en las mismas el personal de apoyo educativo. Participaron 260 estudiantes de ESO y Bachillerato, a los que se les administró un cuestionario ad hoc. Los resultados mostraron que la mayoría de los estudiantes conocían a alguna persona con discapacidad (77,6%), pero sólo la mitad se relacionaba con ellas (48,1%). Los estudiantes valoraron la presencia y el trabajo del personal de apoyo educativo como importante y positivo (8,5 sobre 10), sin que su presencia supusiese una barrera para relacionarse con las personas con discapacidad (3 sobre 10). Finalmente, la mayor parte de los estudiantes cree que sería interesante y estarían dispuestos a prestar ayuda a las personas con discapacidad en el ámbito de la Educación Física (7,9 sobre 10).
Homocysteine metabolism in rodent models with hyperhomocysteinemia. Part 1: genetic models
Authors: Иванов А.В. , Вирюс Э.Д. , Логинов В.И. , Зимина И.С. , Бурдённый А.М. , Александрин В.В. , Кубатиев А.А. 
Published: December 2020

Моделирование гипергомоцистеинемии на грызунах является одним из основных способов изучения роли гомоцистеина в патофизиологии различных заболеваний (инфаркта миокарда, инсультов, когнитивных нарушений, болезни Альцгеймера, почечной недостаточности и др.). В настоящем обзоре рассмотрены биохимичекие аспекты метаболизма гомоцистеина, генетические способы моделирования гипергомоцистеинемии на крысах и мышах и их влияние на метаболизм как самого гомоцистеина так и на связанные с ним метаболиты: метионин, цистеин, S-аденозилметионин, S-аденозилгомоцистеин.
Modeling hyperhomocysteinemia in rodents is a common way to study the role of homocysteine in pathogenesis of various diseases (myocardial infarction, stroke, cognitive impairment, Alzheimer’s disease, kidney failure, etc.). This review focuses on biochemical aspects of homocysteine metabolism, genetic methods for modeling hyperhomocysteinemia in rats and mice, and effects of these models on metabolism of both homocysteine itself and related metabolites (methionine, cysteine, S-adenosylmethionine, S-adenosylhomocysteine).
Neointimal phosphoribosiltransftrase is a proinflammatori molecule characterizing severiti of rheumatoid arthritis
Authors: Полякова Ю.В. , Сивордова Л.Е. , Ахвердян Ю.Р. , Шилова Л.Н. , Заводовский Б.В. 
Published: December 2020

Никотинамид фосфорибозилтрансфераза (Nampt) стимулирует синтез матричных металлопротеиназ и хемокинов, поддерживающих синовиальное воспаление, обусловленное лейкоцитарной инфильтрацией. Положительная корреляция между Nampt и C-реактивным белком подтверждает его роль как медиатора воспаления. Считается, что повышенные концентрации Nampt могут стимулировать системное воспаление. Цель исследования - изучение концентрации Nampt в сыворотке крови у больных ревматоидным артритом. Методика. Концентрацию Nampt в сыворотке крови определяли непрямым методом твердофазного иммуноферментного анализа с использованием коммерческих тест систем (RaiBiotech, cat№ EIA-VIS-1) согласно инструкции изготовителя. Результаты. Повышенный уровень Nampt в сыворотке крови был выявлен у 84,29% пациентов. Больные ревматоидным артритом с повышенным уровнем Nampt статистически значимо чаще имели более высокую степень активности (II степень активности) по индексу DAS28 - высокий уровень антител к цитруллированному пептиду, более высокий уровень С-реактивного белка, СОЭ, внесуставные проявления заболевания. Заключение. Предполагается, что Nampt может рассматриваться как важное звено в поддержании воспаления при ревматоидном артрите и потенциальная молекула для направленного воздействия на воспалительный процесс.
Nicotinamide phosphoribosyltransferase (NAMPT) stimulates synthesis of matrix metalloproteinases and chemokines, which support synovial inflammation caused by leukocyte infiltration. A positive correlation between NAMPT and C-reactive protein confirms the role of NAMPT as an inflammatory mediator. Increased concentrations of NAMPT are considered stimulators of systemic inflammation. The aim of this study was to evaluate serum concentrations of NAMPT in patients with rheumatoid arthritis. Methods. Serum concentration of NAMPT was determined by indirect enzyme-linked immunosorbent assay with commercial kits (RaiBiotech, cat.# EIA-VIS-1) according to the manufacturer’s instructions. Results. Elevated serum NAMPT was detected in 84.29% of patients. Rheumatoid arthritis patients with higher NAMPT concentrations significantly more likely had a higher activity score DAS28 (disease activity degree II), a high level of antibodies to citrullinated peptide vimentin, higher levels of C-reactive protein, and higher red blood cell sedimentation rate. Conclusion. NAMPT can be regarded as an important component of the pathogenesis of rheumatoid arthritis and a candidate target molecule for therapy.
Protein Footprinting, Conformational Dynamics and Interface-Adjacent Neutralization ‘Hotspots’ in the SARS-CoV-2 Spike Protein Receptor Binding Domain / Human ACE2 Interaction
Authors: Narang Dominic , Balmer Matthew , James D. Andrew , Wilson Derek 
Published: December 2020

This study provides an HDX-MS based analysis of the interaction between the SARS-CoV-2 spike protein and the human Angiotensin Converting Enzyme 2. - The data agree exactly with the X-ray co-crystal structure of this complex, but provide additional information based on shifts in dynamics that are observed just outside the interface. - These dynamic changes occur specifically in regions that are the primary targets of neutralizing antibodies that target spike protein, suggesting that the neutralization mechanism may result from suppression of dynamic shifts in the spike Receptor Binding Domain (RBD) that are necessary for favorable binding thermodynamics in the spike / ACE2 interaction.
Rapid Characterisation of Suspensions for Waste Treatment and Resource Recovery
Authors: Wardrop Joshua , Baldock Sara J. , coote ian , Demaine Rachael , Fielden Peter R. , Martin Alastair 
Published: December 2020

A simple device for the conduct of stepped pressure filtration measurements is described together with methods for making the empirical measurements and interpreting the data obtained. The data interpretation method applies a multi-step systematic approach, with each step supported by statistical justification, to characterise: filter cake particle stress, filtration diffusivity and cake hydraulic resistivity from a single stepped pressure experiment. The methods enable different flocculant materials to be more rapidly and more appropriately screened than conventional jar tests and large scale filtration trials. The methods are applied to the characterisation of a paint residue treated with aluminium sulphate and “PolyClay”.The work shows that the addition of “PolyClay” as a filter aide reduces the hydraulic resistivity at lower solids concentrations but increases it at higher concentrations whilst simultaneously increasing the particle stress. Together these have a combined deleterious effect on the time and energy required to dewater the residues to high solids concentration by filtration. The results also show that a significant change in suspension behaviour occurs between the “PolyClay” doses of 140 mg l-1 and 660 mg l-1 and that further changes up to “PolyClay” doses of 1600 mg l-1 are more modest. The results indicate the existence an opportunity to reduce “PolyClay” dose into a range between 10% and 50% of current practice. In addition the results provide evidence that alternative, centrifuge based, technology is worthy of investigation.
CALIDAD DEL SERVICIO DE TRANSPORTE URBANO BASADO EN PERCEPCIONES DE LOS USUARIOS, TRUJILLO – 2019
Authors: Gaytan Reyna Karina Liliana , Ulloa Rubio Bertha , Díaz Sotomayor Segundo Luis Martín 
Published: December 2020

El objetivo de este estudio es descubrir la calidad del servicio de autobuses urbanos de acuerdo con lo que perciben sus usuarios. Los resultados de este estudio nos detallan que lo que perciben los usuarios sirven como medio para evaluar la calidad del servicio. Para recopilar datos sobre los comentarios de los pasajeros, se realizó una encuesta y se pidió a los encuestados que calificaran algunas de las características de calidad del servicio de autobuses urbanos de acuerdo con las vistas mínimas del servicio de autobuses. Las técnicas estadísticas combinadas con el análisis descriptivo nos asistieron para un correcto análisis de datos. De estos análisis se extrajeron cinco dimensiones: elementos tangibles, confiabilidad, capacidad de respuesta, seguridad y empatía, que se han extraído junto con sus valores percibidos. Usando las técnicas estadísticas, se ha establecido una escala para conocer el nivel de servicio del transporte de autobús de Trujillo. El rango de esta escala varía de 1 a 5 que representa la mejor o peor calidad del servicio.
Se encuentro que la seguridad, la comodidad y la capacidad de respuesta caen dentro del grupo más valorado por los usuarios. Gracias al análisis en esta investigación y a sus resultados, se redactaron recomendaciones para el sector de transporte en la ciudad de Trujillo.
The first wave of the COVID-19 pandemic in Spain: characterisation of cases and risk factors for severe outcomes, as at 27 April 2020
Authors:   Working group for the surveillance and control of COVID-19 in Spain
Published: December 2020

Background
The first wave of the coronavirus disease (COVID-19) pandemic spread rapidly in Spain, one of Europe’s most affected countries. A national lockdown was implemented on 15 March 2020.

Aim
To describe reported cases and the impact of national lockdown, and to identify disease severity risk factors.

Methods
National surveillance data were used to describe PCR-confirmed cases as at 27 April 2020. We compared case characteristics by severity categories (hospitalisation, admission to intensive care unit (ICU), death) and identified severity risk factors using multivariable regression.

Results
The epidemic peaked on 20 March. Of 218,652 COVID-19 cases, 45.4% were hospitalised, 4.6% were admitted to ICU and 11.9% died. Among those who died, 94.8% had at least one underlying disease. Healthcare workers (HCWs) represented 22.9% of cases. Males were more likely to have severe outcomes than females. Cardiovascular disease was a consistent risk factor. Patients with pneumonia had higher odds of hospitalisation (odds ratio (OR): 26.63; 95% confidence interval (CI): 25.03–28.33). The strongest predictor of death was age ≥ 80 years (OR: 28.4; 95% CI: 19.85–40.78). Among underlying diseases, chronic renal disease had highest odds of death (OR: 1.47; 95% CI: 1.29–1.68).

Conclusions
COVID-19 case numbers began declining 6 days after the national lockdown. The first wave of the COVID-19 pandemic in Spain had a severe impact on elderly people. Patients with cardiovascular or renal conditions were at higher risk for severe outcomes. A high proportion of cases were HCWs. Enhanced surveillance and control measures in these subgroups are crucial during future COVID-19 waves.
Factores predisponentes a la parvovirosis canina registrados en un hospital de Cuautitlan, México
Authors: Aponte F. A. , Gómez R. V. , Lopez Y. M. 
Published: December 2020

El parvovirus canino (PVC) se restringió inicialmente a infectar a los perros, pero luego seextendió a otras familias como felidae (gatos y otros felinos), procionidae (mapaches, coatíes)y ursidae (osos). A pesar de que su epidemiología no ha sido descrita completamente,el clima parece tener influencia directa en los rangos de presentación. En este trabajo secompararon factores como edad, raza, género, estado vacunal y variables climáticas, conla aparición de la enfermedad en un hospital veterinario de Cuautitlan (México). Mediantela revisión de 3.862 historias clínicas de los años 2016-2017, se encontró una prevalencia de1,86% (72 animales) diagnosticados con PVC, siendo los menores de 7 meses los de mayorsusceptibilidad, especialmente durante los meses de marzo a mayo, con mayor incidencia enabril. La variable aumento de la temperatura ambiental explicó la mayor presentación de laenfermedad, seguida por el sexo hembra, el mayor número de crías, la joven edad y el menorconsumo de alimento.
Caracterización de la citología prepucial en perros adultos
Authors: Sánchez A. E. 
Published: December 2020

Con el objetivo de caracterizar la citología prepucial en perros adultos clínicamente sanos, se muestrearon 50 perros de entre 1 y 12 años, formándose 2 grupos etarios: 1 a 4 años (n=25) y >5 años (n=25) para realizar una comparación. Se realizó examen físico y ultrasonográfico para descartar presencia de neoplasias testiculares. La edad promedio en los grupos fue de 2,78 ± 1,43 años y 7,82 ± 3,12 años, respectivamente. Los recuentos de células epiteliales totales incluyeron células parabasales: 24,32 ± 14,01; células intermedias: 73,07 ± 24,32; y células superficiales: 2,69 ± 1,45. No se observaron diferencias estadísticas entre grupos. El recuento de neutrófilos arrojó una mayor frecuencia de las categorías moderada y abundante en ambos grupos etarios (p≤0,05). El presente estudio caracteriza la citología prepucial normal en perros adultos sanos de diferentes edades, con predominio de células intermedias y cantidad abundante a moderada de neutrófilos.
An Empirical Study on Food and Beverage Service Quality and Customer Satisfaction in Star Graded Hotels in Dambulla
Authors: Bandara WMAH  , Dahanayake SNS  
Published: December 2020

The hotel industry is one of the integral constituents in the flourishing tourism industry and is extremely competitive. In this competitive arena, service quality has become a crucial success factor in maintaining hotel standards. A strong, sustainable, outstanding service industry requires good service quality standards. However, due to the intangible nature of service products, measuring service quality is substantially challengeable than measuring the quality of physical products. Hence, this study attempts to investigate the impact of food and beverage service quality on customer satisfaction in the star graded hotels. Dambulla is one of the major tourist destinations in Sri Lanka, has been identified as the study area. A total of 150 foreign departure tourists who have visited three and above star graded hotels in the respective area were selected through a convenient sampling technique. A widely accepted SERVQUAL model was utilized to ascertain the findings. Primary data were collected through a self-administered structured questionnaire. Descriptive, frequency, Pearson correlation, and multiple regression analysis were conducted to analyze data using SPSS. The results reveal that there is a positive significant impact of tangibility, reliability, responsiveness, assurance of food and beverage service quality on customer satisfaction in the star graded hotels in Dambulla area. On the contrary, empathy shows that there is no impact on customer satisfaction. Moreover, tangibility is the most influential service quality attribute that affects customer satisfaction. Thus, the authorities must pay their attention towards improving the tangible evidence such as staff attires and appearance, aesthetic upkeep of interior and exterior, and provide reliable service for their guests with greater customer care.