bluuebunny/crossref_metadata_2025_split huggingface dataset:
Without borders: youth debaters reimagining the nature and purpose of public dialogue
Authors: Mirra Nicole , Liberation League Debate 
Published: May 2020

PurposeThis paper aims to analyze how a group of middle-school debaters integrated their identities and epistemologies into the traditional literacy practice of debate to advocate for more expansive and inclusive forms of academic and civic discussion. The adult and youth co-researchers of the Debate Liberation League (DLL) detail their creation of a critical debate praxis through the use of spoken word and translanguaging and illustrate how they sought to redesign a foundational activity of English Language Arts on their own terms.Design/methodology/approachDrawing upon critical race and borderlands theories, the authors use critical ethnographic and participatory action research methods to explore how the DLL deconstructed the boundaries of what counts as public dialogue and offered an alternative model of what intergenerational and multi-voiced democratic discourse could look like in English Language Arts (ELA) classrooms and beyond.FindingsThe findings demonstrate how DLL students broke down normative binaries of affirmative/negative and objective/subjective in their debate performances and introduced testimonios as evidence for civic claims to make space for their voices and reimagine deliberation.Originality/valueThis study foregrounds dialogic data generation through a collaborative, intergenerational research approach. It highlights the constructed nature of literacy “rules,” demonstrates youth expertise in reimagining ELA, and offers a pathway toward a more compassionate public sphere.
Examining moderating role of personal identifying information in travel related decisions
Authors: Garg Prerna , Pandey Anoop 
Published: May 2020

Purpose
The purpose of this study is to empirically verify the role of determinants of information quality in shaping attitudes and intention of respondents from major metro cities of India towards electronic word of mouth (e-WOM) using personal identifying information (PII) as a moderator.

Design/methodology/approach
For the purpose of measuring the role of information quality in predicting attitude towards e-WOM (moderated by PII), the study proposes and validates the research framework by collecting responses from 375 respondents with diverse demographics, belonging to select metro cities of India.

Findings
All the constructs of information quality have a significantly positive effect on attitude of travellers towards e-WOM. Attitude further impacts the behavioural intention to book via an online travel agency/agent (OTA). PII successfully moderated all the hypothesized relationships with attitude except review sidedness.

Research implications
The study offers a rationale to fill the gap between information quality and attitude as well as exploring new relationships using PII as a moderating variable. It further opens new avenues in researching the behavioural intention of travellers from metro cities of India with the disruptions created by Web 2.0.

Practical implications
OTAs in this competitive time must try to harmonize their systems to create content that is timely updated, unique, convincing and useful to build long-term relationships and generate continued revenues.

Originality/value
In the context of OTAs in India, this study has successfully identified the most relevant constructs of information quality and examined their effectiveness in creating a positive attitude towards e-WOM. The use of contemporary construct “PII” as a moderator will help marketers develop effective strategies for reducing anonymity in reviews and capturing the intention of experience-oriented travellers from the metro cities of India.
Assistive technology for people with PIMD in challenging scenarios
Authors: Engelhardt Meike , Kosiedowski Michał , Duszyńska Irena 
Published: May 2020

Purpose
The purpose of this study is to examine in what type of scenarios of daily life assistive technology such as the INSENSION system would provide considerable benefit for people with profound intellectual and multiple disabilities (PIMD).

Design/methodology/approach
A series of focus group workshops were held with relatives of people with PIMD and direct support professionals (DSPs), as well as experts in information and communications technology (ICT). They were oriented towards the design thinking approach and moderated as per the Disney method.

Findings
The participants identified transitions from known to unknown caregivers, provision of care during the night and the impact of external factors on a person’s mood as challenging situations within the PIMD context.

Practical implications
Solving these problems would lead to considerable benefits to the affected people. Based on the ideas gathered in workshops, three technological applications for the INSENSION system were derived, i.e. communication application, multimedia player and smart room devices, all of which will provide remedies in specific usage scenarios.

Originality/value
Methods drawing on the participant’s creativity in combination with the workshops’ multi-perspectivity facilitated a direct reference to the daily life of the target group. In this manner, the innovative ICT system INSENSION can be oriented towards the requirements of this vulnerable group.
Employee wellness on the frontline: an interactional psychology perspective
Authors: Solnet David , Subramony Mahesh , Golubovskaya Maria , Snyder Hannah , Gray Whitney , Liberman Olga , Verma Rohit 
Published: May 2020

PurposeEmployee wellness is vital to creating high-quality employee–customer interactions, yet frontline service workers (FLSWs) do not typically engage in, or benefit from, wellness initiatives. This paper aims to conceptually model the interactive influences of organizational and employee factors in influencing FLSW involvement in wellness programs and provides suggestions on how service organizations can enhance wellness behaviors and outcomes.Design/methodology/approachThis paper builds upon classical and contemporary management theories to identify important gaps in knowledge about how employees and firms engage with wellness. Interactive psychology, emphasizing multidirectional interaction between person (employee) and situation (organization) wellness orientation, is introduced.FindingsThe paper develops a model that can be used to assess organizational wellness program effectiveness by emphasizing the interaction of employee and organizational wellness orientation. The model illustrates that wellness effectiveness relies equally on employee agency through an active wellness orientation matched with the organizational wellness orientation.Originality/valueThis paper questions the dominant approaches to assessing the effectiveness of workplace wellness initiatives, arguing for a more humanistic and agentic perspective rather than traditional organizationally centered fiscal measures.
Feminist criminology in an era of misogyny†
Authors: Chesney‐Lind Meda 
Published: May 2020

AbstractIn this address I make the case for continuing to focus criminological research on gender, sexism, and racism within our lives and within our profession. I also provide a brief case study of a topic many would feel falls well outside our field: reproductive rights. Data are reviewed to reveal the impact of gender on the lives of women—notably the devaluation of work done by women, particularly if the work is deemed feminist. Afterward, recent data on the persistence of both sexism and racism in our field are reviewed. Despite gains made by women (notably in the membership of the field), the highest positions in our professional association are held by men, particularly by White men. Data on the importance of reproductive rights to women are then considered, notably the fact that nearly one third of women will need abortion services by the time they reach middle age. Finally, I review recent efforts by conservatives to recriminalize abortion, specifically through the passage of laws making abortion difficult to arrange, or even outlawing the provision of abortion services. These efforts directly involve the criminal justice system in the criminalization of women's bodies.
Pneumothorax triggered by EGFR‐tyrosine kinase inhibitors in three microwave ablation candidates: A review of the literature
Authors: Guo Runqi , LI Yuanming , Bie Zhixin , Li Bin , Li Xiaoguang 
Published: May 2020

AbstractEpidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are widely used in patients with EGFR‐mutant lung cancer. Meanwhile, thermal ablation such as microwave ablation has been an option for selected patients. Herein, we describe three cases of pneumothorax that occurred in microwave ablation (MWA) candidates treated with EGFR‐TKIs. The three patients developed pneumothorax in different periods: case 1 developed pneumothorax two months after MWA and subsequent gefitnib therapy; case 2 took osimertinib for two years and developed pneumothorax before MWA; case 3 took gefitinb for 13 months and experienced bronchopleural fistula after MWA. Although a causal relationship is uncertain, the risk of pneumothorax for these MWA candidates should be considered.Key points
Microwave ablation candidates treated with epidermal growth factor receptor tyrosine kinase inhibitors are more likely to suffer pneumothorax.
The risk of delayed pneumothorax or even bronchopleural fistula in patients pretreated with tyrosine kinase inhibitors should be taken into consideration when selecting patients and performing microwave ablations.
Cytoplasmic, but not nuclear Nrf2 expression, is associated with inferior survival and relapse rate and response to platinum‐based chemotherapy in non‐small cell lung cancer
Authors: Chen Ming‐Jenn , Lin Po‐Lin , Wang Lee , Cheng Ya‐Min , Chen Chih‐Yi , Lee Huei 
Published: May 2020

AbstractBackgroundSeveral studies have previously indicated that nuclear factor erythroid 2‐related factor 2 (Nrf2) expression may promote tumor progression when the Keap1/Nrf2 pathway is activated, but few reports have demonstrated the role of cytoplasmic Nrf2 on tumorigenesis.MethodsImmunohistochemistry was conducted to evaluate Nrf2 expression in 167 tumors from surgically‐resected patients with non‐small cell lung cancer (NSCLC). Univariate and multivariate analyses were performed to examine the association of Nrf2 expression with patients' prognosis. This study was conducted to examine the association of Nrf2 expression with tumor response to cisplatin‐based chemotherapy.ResultsAmong these tumors, 56 and 32 of 167 tumors expressed Nrf2 in the cytoplasm (34% for C+/N‐) and in the cytoplasm/nucleus (19% for C+/N+), but not in the nucleus of tumor cells. Nrf2 was negatively expressed in the remainder of the tumor samples (C‐/N‐, 79 of 167, 47%). Univariate analysis indicated that patients with Nrf2 positive tumors (C+/N‐ plus C+/N+) had worse overall survival (OS), but not relapse‐free survival (RFS) than with Nrf2 negative tumors (C‐/N‐). However, patients with C+/N‐ tumors possessed worse OS and RFS than those with Nrf2 negative tumors (C‐/N‐). Multivariate analysis further confirmed the prognostic significance of patients with Nrf2 positive and C+/N‐ tumors on OS and RFS, but not on RFS for patients with Nrf2 positive tumors. Patients with Nrf2 positive and C+/N‐ tumors were determined to more frequently have an unfavorable response to cisplatin‐based chemotherapy than those with Nrf2 negative tumors.ConclusionsCytoplasmic Nrf2 expression might potentially be used to predict poor prognosis and unfavorable response to cisplatin‐based chemotherapy in patients with NSCLC.Key points
The expression of cytoplasmic Nrf2 showed a significant relationship with patients' response to cisplatin‐based chemotherapy and influenced NSCLC prognosis.
A proteasomal inhibitor such as carfilzomib might be used to improve the outcomes and therapeutic response to cisplatin‐based chemotherapy in patients with tumors showing cytoplasmic Nrf2 expression.
HLA antibody repertoire in infants suggests selectivity in transplacental crossing
Authors: Savulescu Dana M. , Groome Michelle , Malfeld Susan C. K. , Madhi Shabir , Koen Anthonet , Jones Stephanie , Duxbury Vania , Scheuermaier Karine , De Assis Rosa Debbie , Suchard Melinda 
Published: May 2020

AbstractProblemLate in pregnancy, women produce and transfer high amounts of antibodies to the foetus. During gestation, women produce antibodies against human leukocyte antigens (HLA), including antibodies directed at foetal HLA. There is paucity of data on transplacental crossing, specificity and role of HLA antibodies in pregnancy and new‐borns.Method of studyUsing highly sensitive Luminex technology, we measured prevalence of IgG HLA antibodies in 30 mother‐infant pairs six weeks post‐partum. Additionally, in six pregnant women, we measured HLA antibodies longitudinally and HLA‐typed infant DNA to assess whether maternal HLA antibodies were directed at infant specificities.ResultsOverall, 68% of mothers and 44% of infants expressed HLA‐I antibodies and 56% of mothers and 52% of infants expressed HLA‐II antibodies. Infants shared up to 78% of antibodies with their mothers, suggesting that the remaining antibodies were self‐made. Less than 25% of maternal HLA antibodies were detected in infants, possibly due to selection in transplacental crossing. We detected complement‐fixing HLA antibodies in mothers and at low levels in infants. In a third of our pregnant subjects, we detected infant‐directed HLA antibodies.ConclusionOur findings raise the possibility of selection in transplacental crossing of HLA antibodies. As HLA antibodies may act as autoantibodies in the neonate, the mechanism of a selective transfer may give important insights into immune tolerance. Findings also suggest that infants start producing their own HLA antibodies in the first weeks of life, which, together with maternally derived antibodies may impact the infant's immune reaction to HLA proteins.
A randomised controlled trial comparing deep neuromuscular blockade reversed with sugammadex with moderate neuromuscular block reversed with neostigmine
Authors: Boggett S. , Chahal R. , Griffiths J. , Lin J. , Wang D. , Williams Z. , Riedel B. , Bowyer A. , Royse A. , Royse C. 
Published: May 2020

SummaryDeep neuromuscular block aims to improve operative conditions during laparoscopic surgery with a lower intra‐abdominal pressure. Studies are conflicting on whether meaningful improvements in quality of recovery occur beyond emergence, and whether lower intra‐abdominal pressure is achieved. In this pragmatic randomised trial with 1:1 allocation, adults undergoing elective laparoscopic surgery were allocated to moderate neuromuscular block reversed with neostigmine, or deep neuromuscular block reversed with sugammadex. Allocation was revealed to the anaesthetist only. Primary outcome was cognitive recovery of the Postoperative Quality of Recovery Scale, 7 days after surgery. Secondary outcomes included recovery in other domains of the Postoperative Quality of Recovery Scale at 15 min and 40 min; days 1, 3, 7, 14; and 1 and 3 months after surgery. Chi‐square test was used for the primary outcome, and generalised linear mixed model for recovery over time between groups. Of 350 participants randomised, 140 (deep) and 144 (moderate) were analysed for the primary outcome. There was no difference in the Postoperative Quality of Recovery Scale cognitive domain at day 7 (deep 92.9% vs. moderate 91.8%, OR 1.164; 95%CI 0.486–2.788, p = 0.826), or at any other time‐point. No significant difference was observed for physiological, emotive, activities of daily living, nociception, or overall recovery. Length of stay in the recovery area (mean (SD) deep 108 (58) vs. moderate 109 (57) min, p = 0.78) and hospital (1.8 (1.9) vs. 2.6 (3.5) days, p = 0.019) was not different. Intra‐abdominal pressure and surgical operating conditions were not different between groups. Deep neuromuscular block did not improve quality of recovery compared with moderate neuromuscular block in operative laparoscopic surgery over a 1‐h duration.
Multidisciplinary guidance for safe tracheostomy care during the COVID‐19 pandemic: the NHS National Patient Safety Improvement Programme (NatPatSIP)
Authors: McGrath B. A. , Ashby N. , Birchall M. , Dean P. , Doherty C. , Ferguson K. , Gimblett J. , Grocott M. , Jacob T. , Kerawala C. , Macnaughton P. , Magennis P. , Moonesinghe R. , Twose P. , Wallace S. , Higgs A. 
Published: May 2020

SummaryThe COVID‐19 pandemic is causing a significant increase in the number of patients requiring relatively prolonged invasive mechanical ventilation and an associated surge in patients who need a tracheostomy to facilitate weaning from respiratory support. In parallel, there has been a global increase in guidance from professional bodies representing staff who care for patients with tracheostomies at different points in their acute hospital journey, rehabilitation and recovery. Of concern are the risks to healthcare staff of infection arising from tracheostomy insertion and caring for patients with a tracheostomy. Hospitals are also facing extraordinary demands on critical care services such that many patients who require a tracheostomy will be managed outside established intensive care or head and neck units and cared for by staff with little tracheostomy experience. These concerns led NHS England and NHS Improvement to expedite the National Patient Safety Improvement Programme’s ‘Safe Tracheostomy Care’ workstream as part of the NHS COVID‐19 response. Supporting this workstream, UK stakeholder organisations involved in tracheostomy care were invited to develop consensus guidance based on: expert opinion; the best available published literature; and existing multidisciplinary guidelines. Topics with direct relevance for frontline staff were identified. This consensus guidance includes: infectivity of patients with respect to tracheostomy indications and timing; aerosol‐generating procedures and risks to staff; insertion procedures; and management following tracheostomy.
Precipitation gradients, plant biogeography, and the incidence of drip‐tips in Cerrado plant species
Authors: Sullivan Megan K. , Queenborough Simon A. 
Published: May 2020

AbstractExamining how both climate and species distribution patterns correlate with leaf morphology can give insights into the ecological and evolutionary patterns that drive adaptive selection of leaf form and function. Drip‐tips are a common feature of leaves in rain forest tree species; they are thought to be an adaptation that aids leaf drying and maximizes photosynthesis in areas with high‐rainfall climates. We tested whether this macroecological pattern holds true across the precipitation gradients in a non‐rain forest region—the woodland savannas of Brazil known as the Cerrado—and compared our results with previous studies from Amazonia. Drip‐tips were, as expected, less common overall in the drier Cerrado than in Amazonia. In addition, within the Cerrado, drip‐tips were more prevalent in areas with higher rainfall as well as in Cerrado sites that were closer to Amazonia. Moreover, species that occurred across both the Cerrado and Amazonia had drip‐tips more often than species that were found only in the Cerrado. These findings support the hypothesis that drip‐tips are adaptive and that either the cost of retaining drip‐tips is low or that in drier regions they have other benefits. Abstract in Portuguese is available with online material.
Altered cortisol metabolism in individuals with HNF1A‐MODY
Authors: Juszczak Agata , Gilligan Lorna C. , Hughes Beverly A. , Hassan‐Smith Zaki K. , McCarthy Mark I. , Arlt Wiebke , Tomlinson Jeremy W. , Owen Katharine R. 
Published: May 2020

AbstractObjective and contextMaturity onset diabetes of the young due to variants in HNF1A (HNF1A‐MODY) is the most common form of monogenic diabetes. Individuals with HNF1A‐MODY usually have a lean phenotype which contrasts with type 2 diabetes (T2DM). Data from hepatocytes derived from Hnf1a knock‐out mice demonstrated dysregulation of 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1), which regulates glucocorticoid availability and action in target tissues, together with 11β‐HSD2 and steroid A‐ring reductases, 5α‐ and 5β‐reductase. We proposed that altered glucocorticoid metabolism might underpin some of the phenotypic differences between patients with HNF1A‐MODY and those with T2DM.DesignA retrospective matched cohort study.Patients and measurements24‐hours urine steroid metabolome profiling was carried out by gas chromatography‐mass spectrometry in 35 subjects with HNF1A‐MODY, 35 individuals with T2DM and 35 healthy controls matched for age, sex and BMI. The steroid metabolites were expressed as μg/L in all groups and measured in mid‐morning urine in diabetic subjects and 24‐hour urine collection in healthy controls. Hence, only ratios were compared not the individual steroids. Established ratios of glucocorticoid metabolites were used to estimate 11β‐HSD1/2 and 5α‐ and 5β‐reductase activities.ResultsWhile 11β‐HSD1 activity was similar in all groups, 11β‐HSD2 activity was significantly lower in subjects with HNF1A‐MODY and T2DM than in healthy controls. The ratio of 5β‐ to 5α‐metabolites of cortisol was higher in subjects with HNF1A‐MODY than in T2DM and healthy controls, probably due to increased activity of the 5β‐reductase (AKR1D1) in HNF1A‐MODY.ConclusionsThis is the first report of steroid metabolites in HNF1A‐MODY. We have identified distinct differences in steroid metabolism pathways in subjects with HNF1A‐MODY that have the potential to alter steroid hormone availability. Further studies are required to explore whether these changes link to phenotype.
Prognostic factors for the outcome of Bells' palsy: A cohort register‐based study
Authors: Urban Elisabeth , Volk Gerd Fabian , Geißler Katharina , Thielker Jovanna , Dittberner Andreas , Klingner Carsten , Witte Otto W. , Guntinas‐Lichius Orlando 
Published: May 2020

AbstractObjectivesThere is a lack of data on patients' and diagnostic factors for prognostication of complete recovery in patients with Bell's palsy.Design and settingCohort register‐based study of 368 patients with Bell's palsy and uniform diagnostics and standardised treatment in a university hospital from 2007 to 2017 (49% female, median age: 51 years).Main outcome measuresClinical data, facial grading, electrodiagnostics, motor function tests, non‐motor function tests and onset of prednisolone therapy were assessed for their impact on the probability of complete recovery using univariable and multivariable statistics.ResultsMedian onset of treatment was 1.5 days. 46% of patients had a House‐Brackmann scale at baseline of ≥ III. The median recovery time was 2.6 months (95% confidence interval [CI] = 2.1‐3.0). 54.9% achieved a complete recovery. If prednisolone therapy started later than 96 hours after onset, the recovery rate decreased significantly. Beyond less severe palsy, no abnormal electroneurography side difference, no pathological spontaneous activity in electromyography and normal stapedius reflex testing were the most powerful tool for prognostication of recovery after Bell's palsy.ConclusionBeyond severity of the palsy, facial electrodiagnostics and stapedius reflex testing are the most powerful tool for prognostication of recovery time after Bell's palsy. Prednisolone therapy should have started at best within a time window of 96 hours after onset to reach the highest probability of complete recovery.