bluuebunny/crossref_metadata_2025_split huggingface dataset:
Down-regulation of miRNA-196b expression inhibits the proliferation, migration and invasiveness of HepG2 cells while promoting their apoptosis via the PI3K/Akt signaling pathway
Authors: Xu Fanggui , Zhu Feng , Wang Wulin , Gao Wenjie , Chen Xin , Yu Chunzhao 
Published: June 2020

The purpose of this study was to investigate the effects of microRNA-196b (miRNA-196b) on proliferation, migration, invasiveness and apoptosis of hepatocellular carcinoma cell line (HepG2), and the mechanism involved. MiRNA-196b inhibitor or negative control were transfected into HepG2 cells, while empty liposome vector was used as normal control. The results of transfection were assessed using real-time quantitative polymerase chain reaction (qRT-PCR). Cell proliferation, migration, invasiveness and apoptosis were determined using cell counting kit 8 (CCK-8), scratch test, Transwell invasion assay, and flow cytometric analysis, respectively. The expressions of PIK3, Akt and p-Akt proteins were determined using Western blotting. The HepG2 cells were also treated with PI3K/Akt signaling pathway inhibitor LY294002, and its effect on cell proliferation, migration, invasion, and apoptosis, and expressions of PIK3, Akt, and p-Akt proteins were determined. The results of RT-PCR showed that the relative expression of miRNA-196b in the inhibitor group (0.42 ± 0.13) was significantly lower than that in the blank control group (0.96 ± 0.10) and the negative control group (1.01 ± 0.32) (p < 0.05). The miRNA-196b inhibitor significantly and time-dependently reduced the invasiveness, proliferation migration abilities of HepG2 cells, while promoting their apoptosis (p < 0.05). The expressions of PIK3 and p-Akt proteins were significantly down-regulated in the inhibitor group, when compared with normal and negative control groups (p < 0.05). However, there were no significant differences in the expression of Akt protein among the groups (p > 0.05). After treatment of HepG2 cells with PI3K/Akt signaling pathway inhibitor LY294002, the proliferative, migratory and invasive abilities of cells in the treatment group were significantly enhanced, while cell apoptosis was significantly reduced (p < 0.05). Similarly, the protein expressions of PIK3 and p-Akt in the non-treatment group was significantly upregulated, relative to the treatment group (p < 0.05), but there was no significant difference in the expression of Akt protein between the two groups (p > 0.05). Downregulation of miRNA-196b expression inhibits the proliferation, migration and invasiveness of HepG2 cells, while promoting their apoptosis via a mechanism involving the PI3K/Akt signaling pathway.
Nitric oxide donor andrographolide enhances humoral and cell-mediated immune responses
Authors: Zhang Bing , Yang Bo , Du Lijun , Guo Yunfen 
Published: June 2020

The present study was aimed to investigate the regulatory effect of Nitric oxide donor andrographolide (Q-1) on cellular immunity in patients with chronic hepatitis B. Peripheral blood mononuclear cells (PBMCs) were isolated from patients with chronic hepatitis B. Cell viability was assessed using 3"‘(4,5"‘dimethyl"‘thiazol"‘2"‘yl)"‘2,5"‘diphenyl"‘2H"‘tetrazolium bromide (MTT) assay. The levels of expression of interferon gamma (IFN-Î³), interleukin 4 (IL-4), interleukin 10 (IL-10) and tumor necrosis factor Î± (TFN-Î±) in PBMCs of patients with chronic hepatitis B were determined using real-time quantitative polymerase chain reaction (qRT-PCR). Anti-HBV effect of isolated HBV DNA was also assessed in vitro. Q-1 had no significant effect on the viability of Vero and isolated PBMCs (p > 0.05). The expression of IFN-Î³ in PBMCs of control patients significantly and time-dependently increased after treatment with Q-1, but the expressions of IL-4 and IL-10 in PBMCs of patients with chronic hepatitis B were decreased significantly and time-dependently (p < 0.05). The function of Th1 cells was significantly enhanced by Q-1 treatment (p < 0.05). The mean replication of HBV DNA in HepG2cells at the three concentrations of Q-1 and adefovir were 3.96 í— 106, 4.13 í— 106 and 4.53 í— 106 copies/mL, respectively. There was no significant difference in the expression of HBV DNA among the concentration levels. These results indicate that andrographolide enhances the function of HBV-specific T cells in patients with chronic hepatitis B.
Equality and Merit. Through Experiments to Normative Justice
Authors: Leist Anton 
Published: June 2020

Abstract
When we want to justify claims against one another, we discover that conceptual thought alone is not sufficient to legitimize property and income in the relative and proper proportions among members of a productive group. Instead, the basis for justification should also be seen in motivational states, validated less by rational thought than by an effective behaviour. To circumnavigate otherwise dangerously utopian claims to justice, the social sciences, and especially behavioural economics, are the most reliable basis for normative distributive justice. This article builds on recent findings of experiments, first of all in order to give proof of the extent to which a general behavioural tendency towards equality is widespread among people, and second of all in order to highlight ‘desert’ and ‘need’ as the crucial criteria of just distribution, which will then sum up to justified inequality in the economic sphere.
Habermas’s Politics of Rational Freedom: Navigating the History of Philosophy between Faith and Knowledge
Authors: Verovšek Peter J. 
Published: June 2020

Abstract
Despite his hostility to religion in his early career, since the turn of the century Habermas has devoted his research to the relationship between faith and knowledge. His two-volume Auch eine Geschichte der Philosophie is the culmination of this project. Spurred by the attacks of 9/11 and the growing conflict between religion and the forces of secularization, I argue that this philosophy of history is the centerpiece of an important turning point in Habermas’s intellectual development. Instead of interpreting religion merely as part of the history of postmetaphysical thinking, Habermas now sees it as a crucial normative resource for both philosophy and social cohesion in the future aswell. Despite its backward-looking approach,my basic thesis is that this book is best understood as a forward-looking appeal for a tolerant, self-reflective democratic politics that brings religious and secular citizens together dialogically through the cooperative use of their rational freedom.
Luck Egalitarianism and Relational Egalitarianism: An Internal Tension in Cohen’s Theory of Justice
Authors: Chen Jiangjin 
Published: June 2020

Abstract
Relational Egalitarianism focuses on the construction of equal social relationships between persons. It strongly opposes luck egalitarianism, which understands equality as a distributive ideal. In Cohen’s theory of justice, luck egalitarianism and relational egalitarianism simultaneously exist, and Cohen provides arguments corresponding to each. In this paper, we explore the manifestation of tension between these two forms of egalitarianism in his theory. In addition, we also reconstruct some possible solutions provided by Cohen to soften this tension, including the three approaches of market mechanism, egalitarian ethos and value pluralism, and find them to be unsuccessful. This tension is a serious challenge that needs to be addressed in Cohen’s theory of justice.
Technological and antioxidant properties of proteins obtained from waste potato juice
Authors: Jeżowski Paweł , Polcyn Karolina , Tomkowiak Agnieszka , Rybicka Iga , Radzikowska Dominika 
Published: June 2020

AbstractThe article presents the technological and antioxidant properties of potato juice (PJ) protein concentrate obtained by the novel ultrafiltration method. Commercial products, obtained from waste PJ by the traditional method of acid coagulation of proteins, were studied for comparison. Functional properties such as water or oil absorption, foaming capacity, and foam stability (FS) as well as solubility at various pH were assessed. Moreover, the total phenolic compound content, antioxidant activity, and mineral composition were determined. The results showed that PJ protein concentrate obtained by ultrafiltration has good oil absorption properties (6.30 mL/g), which is more than two times higher than the commercial proteins used in the comparison (P2 = 2.33 mL/g and P3 = 2.67 mL/g). Moreover, the ability to create and stabilize foam was also higher (FS ranging from 20.0% at pH = 10 to 11.3% at pH = 2 after 60 min of testing). It had higher content of macro- and microelements and antioxidant activity compared to other samples. Therefore, it is possible to obtain interesting potato protein concentrate from the waste product of the starch production process, which may be an interesting raw material for enriching food.
Photopoetics: Sisyphus Outdone, the Apostrophal Subject and the Elusive Image
Authors: Sánchez-Pardo Esther 
Published: June 2020

AbstractIn Sisyphus Outdone (2012), Nathanaël’s particular tribute to Albert Camus’ The Myth of Sisyphus (1942), the reader faces a challenging hybrid text in which the verbal and visual dimensions intermingle to produce an idiosyncratic type of narrative. Fragmentary, elliptical, a web of quotations, dictums, and meditations on the difficult condition of the individual in the current image-saturated scenario of the first decades of the 21st century, the text manages to propose a rigorous reflection upon crucial aspects of representation from History and temporality, to the Subject now, photography, catastrophe theory, architecture, failure and translation, among the most salient. Sisyphus, I suggest, exhibits a strategic photopoetics which operates as a self-reflective mechanism contributing to the persistence of an impermanent liminal subject and to the (re)production of textuality and the proliferation of voices against silence.
Pilot-scale production of polylactic acid nanofibers by melt electrospinning
Authors: Koenig Kylie , Langensiepen Fabian , Seide Gunnar 
Published: June 2020

Abstract
Melt electrospinning has been used to manufacture fibers with diameters in the low micrometer range, but the production of submicrometer fibers has proven more challenging. In this study, we investigated the feasibility of fabricating polylactic acid nanofibers using polymer grades with the increasing melt flow rates (15–85 g/10 min at 210°C) by melt electrospinning with a 600-nozzle pilot-scale device featuring an integrated climate control system realized as a glass chamber around the spinneret. Previous experiments using this device without appropriate climate control produced fibers exceeding 1 µm in diameter because the drawing of fibers was inhibited by the rapid cooling of the polymer melt. The integrated glass chamber created a temperature gradient exceeding the glass transition temperature of the polymer, which enhanced the drawing of fibers below the spinneret. An average fiber diameter of 810 nm was achieved using Ingeo Biopolymer 6252, and the finest individual fiber (420 nm in diameter) was produced at a spin pump speed of 5 rpm and a spinneret set temperature of 230°C. We have therefore demonstrated the innovative performance of our pilot-scale melt-electrospinning device, which bridges the gap between laboratory-scale and pilot-scale manufacturing and achieves fiber diameters comparable to those produced by conventional solution electrospinning.
„Commercium nach dem Sinn Jesu“
Authors: Dorfner Thomas 
Published: June 2020

Abstract
This paper analyses the market behaviour of the Moravian Church around 1800 as illustrated by the transatlantic trade with Labrador. The pietistic religious community, which originated in Herrnhut/Saxony, founded numerous missionary stations and settlements in the Atlantic world after 1732. In the course of this expansion, a broad range of trade opportunities opened up to the Moravians, which they utilised to finance their exceedingly expensive missionary activities. As this paper sets out, they founded their own Ship’s Company in London in 1770, which imported sought-after raw materials to Great Britain, such as whalebone or fur from Labrador. However, the leadership committee, known as the Unity Elders Conference, imposed strict regulations on the market activities of all Moravians. All trade activities had tobe consistent with biblical standards. This was intended to ensure that the individual merchant or missionary remained free of sin. The Unity Elders considered fair prices tobe of particular importance. This belief also served to distinguish the community from the large number of non-pietistic merchants and their trading practices.
„Große Unternehmungen sind dringend zu widerraten“ – Die Wirtschaft der Deutschen Brüderunität zwischen Ideal und Reform
Authors: Kokel Susanne 
Published: June 2020

Abstract
This essay examines the process of the fundamental reform undertaken by the Moravian Brethren in Germany at the end of the 19th century, building a separate and professionally managed business area within the church. An analysis of institutions, practices and semantics helps to explain this institutional change of a religious entrepreneur. Finally, the case of Sunday work in the church-owned companies illustrates the conditions set for corporate practices by the new institutional structure.
Wettbewerb als „Glaubensbekenntnis“? „Religiöse“ Semantiken im Deutschen Handelstag (1861–1914)
Authors: Gehlen Boris 
Published: June 2020

Abstract
On the basis of general discussions, the paper examines the “religious” functions of competition within the Deutsche Handelstag: firstly, the sensegiving function of “competition”, secondly, its relevance in questions of interest policy and thirdly, semantic change and ritualised communication. By referring to cultural studies approaches, the paper shows that institutions and market practices were discursively (or “religiously”) rationalised and legitimised even if they had nothing in common with competition anymore.
The concept of competition remained undefined in content, was sometimes only ritualised rhetoric and changed semantically as was opportune. Nevertheless, given that interest politics are specific to space and time, an analysis cannot solely rely on abstract cultural studies approaches: The DHT's policy positions cannot be explained by “religious” belief in competition alone as pragmatism was strong. At the same time, a cultural studies perspective contributes to a better understanding of the logic of organisation because it focuses on the changes in semantics and (ritualised) acts of self-assurance.
Geldtheorie und -politik in Preußen Mitte des 18. Jahrhunderts
Authors: Greitens Jan 
Published: June 2020

Abstract
In the history of economic thought, monetary theories in the Germanspeaking world of the early modern era are considered backward compared to the approaches in other European countries. This backwardness can be illustrated by two authors from the mid-18th century who were not only contemporaries but also successively in the service of Frederick II (“the Great”) of Prussia. The first is Johann Philipp Graumann, one of the 'projectors' of the 18th century. As master of the mints in Prussia, he developed a coin project, where he tried to implement a new monetary standard to promote trade, generate seigniorage income and implement the Prussian coins as a kind of a reserve currency. In his writings, he developed a typical mercantilistic monetary theory with a clear understanding of the mechanism in the balance of payments. But even when he tried to include credit instruments, he did not take banks or broader financial markets into account. The second thinker is Johann Heinrich Gottlob Justi, who took the opposite position concerning the coin project as well as in his theory. He defended a strictly metalistic monetary approach where the value of money is only based on the metal's value. While Graumann rejected the English coin system, Justi recommended its laws for countries without their own mines, because the sovereign should not misuse his right of coinage. For him, the monetary system had tobe reliable and stable to serve trade and economic development.
Multiparty Non-Interactive Key Exchange and More From Isogenies on Elliptic Curves
Authors: Boneh Dan , Glass Darren , Krashen Daniel , Lauter Kristin , Sharif Shahed , Silverberg Alice , Tibouchi Mehdi , Zhandry Mark 
Published: June 2020

AbstractWe describe a framework for constructing an efficient non-interactive key exchange (NIKE) protocol fornparties for anyn≥ 2. Our approach is based on the problem of computing isogenies between isogenous elliptic curves, which is believed to be difficult. We do not obtain a working protocol because of a missing step that is currently an open mathematical problem. What we need to complete our protocol is an efficient algorithm that takes as input an abelian variety presented as a product of isogenous elliptic curves, and outputs an isomorphism invariant of the abelian variety.Our framework builds acryptographic invariant map, which is a new primitive closely related to a cryptographic multilinear map, but whose range does not necessarily have a group structure. Nevertheless, we show that a cryptographic invariant map can be used to build several cryptographic primitives, including NIKE, that were previously constructed from multilinear maps and indistinguishability obfuscation.
Recovering Secrets From Prefix-Dependent Leakage
Authors: Ferradi Houda , Géraud Rémi , Guilley Sylvain , Naccache David , Tibouchi Mehdi 
Published: June 2020

AbstractWe discuss how to recover a secret bitstring given partial information obtained during a computation over that string, assuming the computation is a deterministic algorithm processing the secret bits sequentially. That abstract situation models certain types of side-channel attacks against discrete logarithm and RSA-based cryptosystems, where the adversary obtains information not on the secret exponent directly, but instead on the group or ring element that varies at each step of the exponentiation algorithm.Our main result shows that for a leakage of a single bit per iteration, under suitable statistical independence assumptions, one can recover the whole secret bitstring in polynomial time. We also discuss how to cope with imperfect leakage, extend the model to k-bit leaks, and show how our algorithm yields attacks on popular cryptosystems such as (EC)DSA.
Self-dual DeepBKZ for finding short lattice vectors
Authors: Yasuda Masaya 
Published: June 2020

AbstractIn recent years, the block Korkine-Zolotarev (BKZ) and its variants such as BKZ 2.0 have been used as de facto algorithms to estimate the security of a lattice-based cryptosystem. In 2017, DeepBKZ was proposed as a mathematical improvement of BKZ, which calls LLL with deep insertions (DeepLLL) as a subroutine alternative to LLL. DeepBKZ can find a short lattice vector by smaller blocksizes than BKZ. In this paper, we develop a self-dual variant of DeepBKZ, as in the work of Micciancio and Walter for self-dual BKZ. Like DeepBKZ, our self-dual DeepBKZ calls both DeepLLL and its dual variant as main subroutines in order to accelerate to find a very short lattice vector. We also report experimental results of DeepBKZ and our self-dual DeepBKZ for random bases on the Darmstadt SVP challenge.
Thalidomide-induced serious RR interval prolongation (longest interval >5.0 s) in multiple myeloma patient with rectal cancer: A case report
Authors: Huang Li , Kuang Yuemin , Jiang Zhiyong , Zhu Yan , Luo Xinguo , Shi Fangjing , Hu Shanshan , Gao Xinfang 
Published: June 2020

Abstract
Primary secondary tumor increased recently with the use of immunomodulatory drugs in patients with multiple myeloma (MM). However, MM with prior diagnosis of primary secondary tumor is relatively rare. In this study, we reported an MM patient with prior diagnosis of rectal cancer. In brief, an 85-year-old man was first diagnosed with rectal cancer. Given the age, heart failure and small-cell hypochromic anemia (hemoglobin level: 54 g/L), rectal cancer resection was not advised and symptomatic treatments were performed (including sufficient iron supplementation). Eight months later, the patient was diagnosed with MM due to worsening anemia. Anemia and heart failure were corrected after three cycles of treatment with thalidomide, dexamethasone and capecitabine. Radical resection of rectal carcinoma (Hartmann) was finally performed due to acute abdominal distension. Meanwhile, RR interval prolongation (longest interval >5.0 s) and atrial fibrillation occurred in the fifth cycle treatment. One month after discontinuation of thalidomide, RR interval returned to normal range, while atrial fibrillation developed into persistent atrial fibrillation.
Crystal structure of catena-poly[chlorido-(μ2-formato-κ2
O:O′)-(1,10-phenathroline-κ2
N,N′)copper(II)], C26H18Cl2Cu2N4O4
Authors: Li Xia , Liu Shangjun , Shen Mingle , Yan Weihong 
Published: June 2020

Abstract
C26H18Cl2Cu2N4O4, monoclinic, P21/c (no. 14), a = 9.5129(9) Å, b = 17.8130(17) Å, c = 15.2973(12) Å, β = 110.975(5)°, V = 2420.4(4) Å3, Z = 4, R
gt(F) = 0.0269, wR
ref(F
2) = 0.0929, T = 293(2) K.
Cultural outsiders’ evaluations of (im)politeness in Finland and in France
Authors: Isosävi Johanna 
Published: June 2020

AbstractIntercultural interaction may be complicated by differing verbal and nonverbal displays of (im)politeness. Yet cultural outsiders’ evaluations of (im)politeness have not been widely examined. To fill this gap, this study investigated perceptions of Finnish politeness among French people living in Finland and perceptions of French politeness among Finns currently or previously living in France. Focus groups were used in order to study culturally shared (im)politeness norms and their variations. Based on a dialogical discourse analysis of five focus group discussions, it is argued that personal space emerges as a salient factor for politeness in Finland, while verbal and nonverbal rapport is more important in France. These overarching themes - personal space and rapport - led to discussions about greetings, silence and holding doors open. Greeting and opening doors appeared more categorical in France, while silence was better tolerated in Finland. In addition to dominant norms, regional and individual variations were reported. Overall, (im)politeness norms appeared to be vaguer in Finland than in France. Building upon this study, future research should examine if changes emerge in Finnish (im)politeness norms related to rapport or if space remains more valued.
Towards an emic understanding of Mianzi giving in the Chinese context
Authors: Li Hui 
Published: June 2020

AbstractFace-giving is an understudied notion among the studies of face and facework. This article aims to enhance the understanding of the concept by exploring how the first-order concept of mianzi giving is understood by native members. By examining native discourses in which mianzi giving is explicitly mentioned, we find that in addition to being based on the actor’s intention or the recipient’s feeling, the interpretation of mianzi giving can also be based on the interpersonal consequence of an act grounded in the understanding of the (meta)participant, who takes the footing of the author in the Goffmanian sense. In the (meta)participant’s understanding, mianzi giving is understood as a marked and favorable alternative act with reference to the empirical or moral parameter evoked in the local interaction.