bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emotional Intelligence and Immigrant Entrepreneurship Development: A Correlation Analysis of the Lebanese Family Entrepreneurships in Nigeria
Authors: Agbim Kenneth Chukwujioke 
Published: April 2020

The arrival of the first Lebanese immigrant in Lagos in 1890 has been followed by increase in the number of Lebanese immigrants in Nigeria. The immigrants get attached to their families on arrival. This is owing to the instrumental, financial, psychological and emotional supports they receive from their families to enable them assimilate into the Nigerian community. In spite of their contributions to the economic and infrastructural development of Nigeria through the family-owned immigrant entrepreneurships they have developed, no study seems to have been conducted in this area. Consequently, based on data from selected Lebanese family-owned entrepreneurships, this study examines the relationship between emotional intelligence and immigrant entrepreneurship development. The study adopted mail questionnaire survey design. The generated data through questionnaire were analyzed using Pearson’s correlation. It was found that emotional intelligence is significantly related to the dimensions of immigrant entrepreneurship development, that is, entrepreneurial intention, entrepreneurial capabilities, entrepreneurial networking and entrepreneurial success. Based on the results, the study recommends exposing new immigrants and immigrant entrepreneurs to trainings and programs that will improve their emotional intelligence, entrepreneurial behaviour, capabilities, networking attitude and success mindset. The ultimate effect of these trainings and programs is increase in the development of immigrant entrepreneurships.
PREDIKSI JUMLAH CALON PESERTA DIDIK BARU MENGGUNAKAN METODE DOUBLE EXPONENTIAL SMOOTHING DARI BROWN
Authors: Aden Aden , Anggela Supriyanti  
Published: April 2020

Peramalan data statistika memerlukan kesesuaian pola data dengan metode peramalan yang digunakan. Tujuan penelitian ini yaitu memprediksi jumlah mahasiswa baru pada tahun ajaran baru menggunakan metode Double Exponential Smoothing satu parameter dari Brown dan mengetahui ketepatan metode Double Exponential Smoothing satu parameter dari Brown menggunakan analisis gallat. Metode penelitian yang digunakan menggunakan metode kuantitatis. Hasil yang diperoleh bahwa Prediksi jumlah peserta didik baru Sekolah dasar Islam Al-Musyarrofah Jakarta dengan menggunakan Metode Double Exponential Smoothing dari Brown pada tahun 2020/2021 64 siswa dan Metode Double Exponential Smoothing satu Parameter dari Brown tepat digunakan pada prediksi jumlah mahasiswa baru di Sekolah Dasar Islam AL-Musyarrofah Jakarta dengan nilai Durbin-Waston 0,59997.
Granulocyte colony-stimulating factor usage in drug-induced neutropenia after kidney transplantation: a single-center experience
Authors: ISİKTAS SAYİLAR Emel , ERSOY Alparslan , ÇELİKÇİ Sedat , AYAR Yavuz , ÖZKALEMKAŞ Fahir , OZKOCAMAN Vildan , ALİ Rıdvan 
Published: April 2020

Introduction. Granulocyte colony-stimulating factor (G-CSF) therapy is commonly used in kidney and liver transplant recipients with severe neutropenia. However, rapid and high increases in neutrophil counts of some patients may occur during treatment. This retrospective study aimed to determine the efficacy and safety of G-CSF treatment in neutropenic kidney transplant recipients.
Methods. Eight kidney transplant recipients treated with G-CSF for drug-induced neutropenia (neutrophil count
O discurso de amor em canções: as formações discursivas da dor e da saudade
Authors: Santos Adelino Pereira dos 
Published: April 2020

Neste trabalho, tomamos como pressupostos teóricos a noção-conceito de formação discursiva, conforme proposta por Michel Pêcheux (1997) e com base no artigo Palavra de amor, de Eni Orlandi (1990) para analisarmos, sob o ponto de vista da Análise de Discurso de linha francesa, fragmentos de canções em língua inglesa e em língua portuguesa. A análise das canções nos permitiu perceber as formações discursivas do amor enquanto dor ou sofrimento e do amor enquanto saudade como constitutivas dos textos, reveladas por regularidades enunciativas em funcionamento através de elementos linguísticos e características dos textos. Na impossibilidade de tratarmos aqui de todos os aspectos investigados sobre o discurso de amor, reiteramos a certeza de que a noção-conceito de formação discursiva, como teorizada por Pêcheux (1997) ainda se faz bastante produtiva. Igualmente, reafirmamos a produtividade do artigo de Orlandi (1990), apesar de seus quase trinta anos de produção de sentidos.
Teaching personal and social responsibility after school: A systematic review
Authors: Baptista Céu , Corte-Real Nuno , Regueiras Leonor , Seo Geumran , Hemphill Michael , Pereira Artur , Dias Cláudia , Martinek Tom , Fonseca António 
Published: April 2020

Background: Teaching Personal and Social Responsibility (TPSR) has been studied and implemented through physical activity in different backgrounds for over three decades. However, there is no systematized review in the literature concerning the after-school context.
Aim: Conducting a systematic review of literature on after-school interventions based on the TPSR model.
Methods: This study was driven by the following research questions: Which were the conclusions regarding the implementation of TPSR in after-school settings? Which research methodologies have been used to assess TPSR in after-school time settings? Which results related to TPSR were reported in after-school time settings? Cochrane protocol guidelines were followed. Papers were selected by two independent researchers, with Cohen’s Kappa value of 81%.
Results and discussion: Twenty-seven papers were selected, thirteen of which were reported with high scores. Most interventions were conducted in the USA on community-based after-school programs, lasting more than nine sessions, and led by school staff who prepared physical activities for youngsters from disadvantaged communities. Most of the reported studies resorted to qualitative methodologies. Some gaps were detected, such as lack of systematization of methods, lack of validity and reliability. Personal and social benefits were found. Other results were grouped into leadership, staff-youngsters relationship, values, transference, and impact on staff lives.
We recommend future studies in the after-school context extend to extend to other countries, with more detailed descriptions of the specific used methods.
Bi-Level ventilation decreases pulmonary shunt and modulates neuroinflammation in a cardiopulmonary resuscitation model
Authors: Ruemmler Robert , Ziebart Alexander , Kuropka Frances , Duenges Bastian , Kamuf Jens , Garcia-Bardon Andreas , Hartmann Erik K. 
Published: April 2020

Background
Optimal ventilation strategies during cardiopulmonary resuscitation are still heavily debated and poorly understood. So far, no convincing evidence could be presented in favour of outcome relevance and necessity of specific ventilation patterns. In recent years, alternative models to the guideline-based intermittent positive pressure ventilation (IPPV) have been proposed. In this randomized controlled trial, we evaluated a bi-level ventilation approach in a porcine model to assess possible physiological advantages for the pulmonary system as well as resulting changes in neuroinflammation compared to standard measures.

Methods
Sixteen male German landrace pigs were anesthetized and instrumented with arterial and venous catheters. Ventricular fibrillation was induced and the animals were left untreated and without ventilation for 4 minutes. After randomization, the animals were assigned to either the guideline-based group (IPPV, tidal volume 8–10 ml/kg, respiratory rate 10/min, FiO21.0) or the bi-level group (inspiratory pressure levels 15–17 cmH2O/5cmH2O, respiratory rate 10/min, FiO21.0). Mechanical chest compressions and interventional ventilation were initiated and after 5 minutes, blood samples, including ventilation/perfusion measurements via multiple inert gas elimination technique, were taken. After 8 minutes, advanced life support including adrenaline administration and defibrillations were started for up to 4 cycles. Animals achieving ROSC were monitored for 6 hours and lungs and brain tissue were harvested for further analyses.

Results
Five of the IPPV and four of the bi-level animals achieved ROSC. While there were no significant differences in gas exchange or hemodynamic values, bi-level treated animals showed less pulmonary shunt directly after ROSC and a tendency to lower inspiratory pressures during CPR. Additionally, cytokine expression of tumour necrosis factor alpha was significantly reduced in hippocampal tissue compared to IPPV animals.

Conclusion
Bi-level ventilation with a constant positive end expiratory pressure and pressure-controlled ventilation is not inferior in terms of oxygenation and decarboxylation when compared to guideline-based IPPV ventilation. Additionally, bi-level ventilation showed signs for a potentially ameliorated neurological outcome as well as less pulmonary shunt following experimental resuscitation. Given the restrictions of the animal model, these advantages should be further examined.
Purification, characterization and antioxidant activities in vitro of polysaccharides from Amaranthus hybridus L.
Authors: Tang Zizhong , Zhou Caixia , Cai Yi , Tang Yujia , Sun Wenjun , Yao Huipeng , Zheng Tianrun , Chen Hui , Xiao Yirong , Shan Zhi , Bu Tongliang , Wang Xiaoli , Huang Lin , Gou Lin 
Published: April 2020

Background
Amaranthus hybridus L. is an annual, erect or less commonly ascending herb that is a member of the Amaranthaceae family. Polysaccharides extracted from traditional Chinese medicines may be effective substances with antioxidant activity.

Methods
In this study, we isolated crude polysaccharides from A. hybridus (AHP-M) using microwave-assisted extraction. Then, the AHP-M was purified by chromatography with DEAE-32 cellulose, and two fractions, AHP-M-1 and AHP-M-2, were obtained. The structural characteristics of AHP-M-1 and AHP-M-2 were investigated, and their antioxidant activities were analyzed in vitro.

Results
We found that the monosaccharide composition of AHP-M-1 was different from that of AHP-M-2. The molecular weights of AHP-M-1 and AHP-M-2 were 77.625 kDa and 93.325 kDa, respectively. The results showed that the antioxidant activity of AHP-M-2 was better than that of AHP-M-1. For AHP-M-2, the DPPH radical scavenging rate at a concentration of 2 mg/mL was 78.87%, the hydroxyl radical scavenging rate was 39.34%, the superoxide anion radical scavenging rate was 80.2%, and the reduction ability of Fe3+ was approximately 0.90. The total antioxidant capacity per milligram of AHP-M-2 was 6.42, which was higher than that of Vitamin C (Vc).

Conclusion
The in vitro test indicated that AHP-M-1 and AHP-M-2 have good antioxidant activity, demonstrating that A. hybridus L. polysaccharide has immense potential as a natural antioxidants.
Aberrant expression of two miRNAs promotes proliferation, hepatitis B virus amplification, migration and invasion of hepatocellular carcinoma cells: evidence from bioinformatic analysis and experimental validation
Authors: Liu Yanming , Cao Yue , Cai Wencan , Wu Liangyin , Zhao Pingsen , Liu Xin-guang 
Published: April 2020

Background
As key negative regulators of gene expression, microRNAs (miRNAs) play an important role in the onset and progression of hepatocellular carcinoma (HCC). This study aimed to identify the miRNAs involved in HCC carcinogenesis and their regulated genes.

Methods
The Gene Expression Omnibus (GEO) dataset (GSE108724) was chosen and explored to identify differentially expressed miRNAs using GEO2R. For the prediction of potential miRNA target genes, the miRTarBase was explored. Enrichment analysis of Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) was performed by the DAVID online tool. The hub genes were screened out using the CytoHubba plug-in ranked by degrees. The networks between miRNAs and hub genes were constructed by Cytoscape software. MiRNA mimics and negative control were transfected into HCC cell lines and their effects on proliferation, hepatitis B virus DNA (HBV-DNA) replication, TP53 expression, migration, and invasion were investigated. The following methods were employed: MTT assay, quantitative PCR (qPCR) assay, western blotting, wound healing assay, and transwell assay.

Results
A total of 50 differentially expressed miRNAs were identified, including 20 upregulated and 30 downregulated miRNAs, in HCC tumor tissues compared to matched adjacent tumor-free tissues. The top three upregulated (miR-221-3p, miR-222-3p, and miR-18-5p) and downregulated (miR-375, miR-214-3p and miR-378d) miRNAs, ranked by |log2 fold change (log2FC)|, were chosen and their potential target genes were predicted. Two gene sets, targeted by the upregulated and the downregulated miRNAs, were identified respectively. GO and KEGG pathway analysis showed that the predicted target genes of upregulated and downregulated miRNAs were mainly enriched in the cell cycle and cancer-related pathways. The top ten hub nodes of gene sets ranked by degrees were identified as hub genes. Analysis of miRNA-hub gene network showed that miR-221-3p and miR-375 modulated most of the hub genes, especially involving regulation of TP53. The q-PCR results showed that miR-221-3p and miR-375 were markedly upregulated and downregulated, respectively, in HCC cells and HCC clinical tissue samples compared to non-tumoral tissues. Furthermore, miR-221-3p overexpression significantly enhanced proliferation, HBV-DNA replication, as well as the migration and invasion of HCC cells, whereas miR-375 overexpression resulted in opposite effects. Western blotting analysis showed that the overexpression of miR-221-3p and miR-375 reduced and increased TP53 expression, respectively.

Conclusion
The present study revealed that miR-211-3p and miR-375 may exert vital effects on cell proliferation, HBV-DNA replication, cell migration, and invasion through the regulation of TP53 expression in HCC.
New Marker for Suspected Open Globe Injury (Perforation or Penetration): Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio
Authors: Yiğit Kenan , Duman Reşat , Duman Rahmi , Yozgat Zubeyir , Çetinkaya Ersan , Sabaner Mehmet Cem 
Published: April 2020

Purpose: To compare the strength of the relationship between the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio(PLR) results of patients with or without open globe injury (perforation and penetration) in the acute period of orbital trauma.
Materials and Methods: Forty patients with open globe injuryand twenty-five patients without open globe injury in the acute period of orbital trauma were enrolled in this retrospective study. Complete blood count measurement results of all subjects were assessed.
Results: There was a significant difference in neutrophil-to-lymphocyte ratio and the platelet-to-lymphocyte ratio between orbital trauma with open globe injury group and without open globe injury group (p=0.001, p=0.006).
Conclusion: Our results of the blood count measurements suggest that the NLR and PLR at first three hours may predict ocular perforation/penetration and the clinicians have to alert are a risk factor of open globe injury.
Meta‐Stable Molecular Configuration Enables Thermally Stable and Solution Processable Organic Charge Transporting Materials
Authors: Liu Tian , Sun Kuangshi , Shen Wei , He Rongxing , Li Ming 
Published: April 2020

AbstractThe construction of state‐of‐the‐art charge transporting materials (CTMs) is challenging in modulating molecular configurations for simultaneously achieving high thermal stability and appreciable solution processability. Herein, N,N′‐bis(1‐indanyl)naphthalene‐1,4,5,8‐tetracarboxylic diimide (NDI‐ID) is served as a theoretical model to investigate the influence of molecular structure on the tradeoff between thermal stability and solubility. Compared with the alkyl substituted analog, the thermal stability of NDI‐ID is enhanced by the intramolecular and intermolecular short contacts, indicating the conformational rigidity dictates the morphological stability of the film phase. On the other hand, the dynamic topological transformation of material molecules occurs during the solvation process and, where the intramolecular hydrogen bonds are attenuated by the interactions with the surrounding solvent, leads to the increased solubility. The meta‐stable molecular configuration endows NDI‐ID a favorable union of superior solution processability and higher thermal stability, and this insight is also perfectly exemplified by the newly designed CTMs. Therefore, these results reveal the significant role of structural dynamics on material properties, which can provide a new train of thought to develop CTMs for highly efficient and stable perovskite solar cells.
The microbiome of pediatric patients with chronic rhinosinusitis
Authors: Stapleton Amanda L. , Shaffer Amber D. , Morris Alison , Li Kelvin , Fitch Adam , Methé Barbara A. 
Published: April 2020

BackgroundThis study aimed to compare the microbiota of pediatric patients with chronic rhinosinusitis (CRS) who are undergoing adenoidectomy to treat their disease with that of healthy control patients.MethodsPatients undergoing adenoidectomy‐only for obstructive sleep apnea (n = 50) and CRS (n = 37) were recruited. Preoperative 22‐item Sino‐Nasal Outcome Test (SNOT‐22) or Sinus and Nasal Quality of Life Survey (SN‐5) were collected. Each patient had samples collected from their nasopharynx (adenoid bed) and nasal cavity (sinus) at the onset of surgery. 16S ribosomal ribonucleic acid (rRNA) gene sequencing was subsequently performed to obtain per sample taxonomic abundances. Statistical analyses included permutational multivariate analysis of variance (PERMANOVA), alpha (within sample) diversity measures, and changes in taxonomic abundance.ResultsMoraxella was the most abundant organism. Nasopharyngeal swabs demonstrated higher alpha diversity compared to the nasal cavity. The diversity was not different based on CRS vs obstructive history. There was an increase in diversity with increasing age, and eczema contributed to a greater difference in diversity between the nasopharynx and nasal cavity. Diversity was not affected by adenoid size; however, use of nasal steroids, inhaled steroids, and antihistamines influenced diversity in both the nasopharynx and nasal cavity. Nasopharyngeal samples were higher in relative abundance for Fusobacterium, Prevotella, Porphyromonas, and Campylobacter compared to the nasal cavity.ConclusionThe nasopharynx and nasal cavity differed in both microbiota composition and diversity. In contrast, no significant difference in composition or diversity were found in CRS vs control patients. Ecological changes in the nasopharyngeal and sinus site may contribute to the etiology for adenoid hypertrophy in both healthy controls and CRS patients.
Hydrocephaly associated with compound heterozygous alterations in TRAPPC12
Authors: Gass Jennifer M. , Head Barbara B. , Shields Sally M. , Stevenson Roger E. , Louie Raymond J. 
Published: April 2020

AbstractBackgroundHydrocephalus is characterized by increased cerebrospinal fluid within the brain, a causally heterogeneous disorder estimated to affect 1 per 1,000 live births, with the most severe cases often leading to fetal demise. The large number of known genetic and environmental factors that contribute to hydrocephalus makes the differential diagnosis challenging.CasesThree consecutive pregnancies of an unrelated couple were found by ultrasound to carry fetuses with hydrocephaly. DNA from two affected fetuses and the parents were subjected to whole exome sequencing. Heterozygous alterations in the TRAPPC12 gene were identified in the parents and compound heterozygous alterations were present in the two affected fetuses. The variant from the father (c.954del) leads to a premature termination of the transcript; the variant from the mother (c.1677+5G>A) affects a splice site which leads to aberrant splicing of the TRAPPC12 transcript.ConclusionCompound heterozygous variants in TRAPPC12, which encodes a protein involved in Golgi trafficking and mitosis, may disrupt normal brain embryogenesis leading to hydrocephalus and recurrent pregnancy loss.
Micropipette Aspiration‐Based Assessment of Single Channel Water Permeability
Authors: Boytsov Danila , Hannesschlaeger Christof , Horner Andreas , Siligan Christine , Pohl Peter 
Published: April 2020

AbstractMeasurements of the unitary hydraulic conductivity of membrane channels, pf, may be hampered by difficulties in producing sufficient quantities of purified and reconstituted proteins. Low yield expression, the purely empiric choice of detergents, as well as protein aggregation and misfolding during reconstitution may result in an average of less than one reconstituted channel per large unilamellar vesicle. This limits their applicability for pf measurements, independent of whether light scattering or fluorescence quenching of encapsulated dyes is monitored. Here the micropipette aspiration technique is adopted because its superb sensitivity allows resolving pf values for one order of magnitude smaller protein densities in sphingomyelin and cholesterol rich giant unilamellar vesicles (GUVs). Protein density is derived from intensity fluctuations that fluorescently labeled channels in the aspirated GUV induce by diffusing through the diffraction limited spot. A perfusion system minimizes unstirred layers in the immediate membrane vicinity as demonstrated by the distribution of both encapsulated and extravesicular aqueous dyes. pf amounted to 2.4 ± 0.1 × 10−13 cm³ s−1 for aquaporin‐1 that served as a test case. The new assay paves the way for directly monitoring the effect that interaction of aquaporins with other proteins or inhibitors may have on pf on a single sample.
‘Lower’ social class of a client evokes class self‐awareness rather than discrimination in clinical reasoning: A video vignette study among British psychological and psychotherapeutic professionals working in the NHS
Authors: Vlietstra Tom , Woodger Nigel , Northeast Tony , McNamara Adam J. , Morison Linda 
Published: April 2020

AbstractObjectiveThe aim of this study was to explore the impact social class biases may have on the diagnosis and treatment of clients by psychological and psychotherapeutic professionals working in the National Health Service (NHS) in Britain.MethodsPsychological and psychotherapeutic professionals working in the NHS were randomised to one of two video vignettes representing a psychological assessment session with either a ‘lower’ or ‘upper’ class client. The accent and dress of the client were varied to elicit class stereotypes. The video and study measures were accessed online via a link to a webpage. Participants completed measures of clinical reasoning, namely diagnosis, risk assessment and treatment, as well as measures of class self‐awareness.ResultsAmong the 156 practitioners who completed the measures there was little difference between the two groups for the clinical reasoning measures. The expectation was that participants believed a ‘lower class’ client was more likely to receive an ‘alcohol or substance misuse’ diagnosis (p = .002; d = 0.40). Unexpectedly, seeing a ‘lower class’ client led to significantly increased class self‐awareness scores, particularly those measures indicating reflection on personal conflicts relating to practitioners’ own social class and the impact such biases may have on their work.ConclusionsThere was little difference in clinical reasoning between the two class conditions. This may be due to client class cues priming the psychologist to reflect on their own potential class biases. Practitioners may benefit from further reflection and training on biases related to substance use and social class.