bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug utilization for common skin diseases: an outpatient based study
Authors: Mate Vijay Haribhau , Gonarkar Satish Balaji , Dhamani Anjum Mehmood 
Published: November 2019

Background: Drug utilization studies are useful for understanding the pattern of drug use in any particular healthcare set-up. This data gives an insight to improve the medical treatment at different layers in the health system. The oobjective of the present study was to assess drug utilization patterns by using core prescribing indicators of WHO and to assess most commonly observed skin disease in Dermatology out patients department (OPD) of tertiary care hospital.Methods: 246 prescriptions from Dermatology OPD were audited. Common skin diseases and the prescribing patterns were analysed from the prescriptions.Results: Average 2.4 drugs per prescription were seen in this study. 38.7% drugs were from National Essential Drug List of India. All the drugs were prescribed by brand names. The fixed dose combinations accounted for 20.6% drugs prescribed. Dosage, dose and duration of treatment were written for 100% of prescriptions. Around 44 different skin diseases were diagnosed amongst 246 patients predominantly cutaneous fungal infections, acne, dermatitis, eczema and psoriasis. About 591 different drugs were used mainly corticosteroids (21%), antibiotics (17%), anti-allergic (16%), antifungals (11%). Common skin conditions receiving corticosteroids were dermatitis (9.9%), eczema (9.1%). Antibiotics (17%), antifungals (11%) and antivirals (1%) were commonly used antimicrobial agents. 55.2% drugs were administered topically while 44.6% received orally.Conclusions: Prescriptions revealed a higher incidence of fungal and bacterial infections. All the medications were prescribed rationally. All prescriptions had proper dosage form, frequency of administration, duration of therapy and diagnosis. However, prescriber should be motivated for prescription of generic drugs and those from essential drug list.
Effect of steroid on platelet count of dengue patients admitted at Sapthagiri Institute of Medical Sciences and Research Centre: a retrospective study
Authors: Hazra Piyali , K. Navya Teja , L. Padma 
Published: November 2019

Background: New treatment strategies are attempted to treat the fatal complications of the dengue infection, as significant numbers of adult and children are affected resulting in considerable economic impact. Corticosteroids in various regimens have been used in the last 2 decades empirically on the basis of immunomodulation or treat the vascular leakage that occurs in severe dengue.Methods: A descriptive study was conducted among 60 patients who were dengue positive and received treatment from the Department of Medicine at SIMSRC during the period of June-August 2018. The study group (30 patient) was given treatment with intravenous dexamethasone 8 mg initially, followed by 4 mg TID for 3 days. The control group (30 patient) received only IV fluids and antipyretics. The rise in the mean platelet counts over three days was analyzed in both groups were analyzed.Results: The results of this study revealed that after 10-12 hours of initiating steroids in the study group, a higher and early rise of platelet count was achieved. There was gradual improvement and increase in platelets in 3 days’ duration in all 30 of the patients. The mean platelet count (the primary outcome) in the study group was significant compared with the control group.Conclusions: At present, realistic approaches for the early intervention and proper treatment protocol are required to be developed to prevent high mortality and morbidity due to dengue. The drawback of this study was, it was not a double-blind placebo-controlled trial and there were less number of patients.
Study of suicides in Mangalore region of South Karnataka, India
Authors: Kumar Jayantha , R. Rekha 
Published: November 2019

Background: To evaluate the various causes of suicides and mental illness of different age groups which enables the patients to commit suicide in both sexes.Methods: The data of suicides was collected from medical records of the different Hospital in Mangalore region of South Karnataka.Results: Total 32 cases of suicides in adults were studied at Mangalore city and district as a whole. The history of suicide was 6(18.7%) was alcoholic, 4(12.5%) were drug addicted (dependent), 5(15.6%) were HIV infected, 3(9.37%) had infertility 4(12.5%) had loss of job, 2(6.25%) had sudden loss of property, 8(25%) had failure in love affair. The clinical manifestations of suicides were (8.25%) had major depression 5(15.6%) had multiple personality disorder. 11(34.3%) were schizophrenic, 6(18.7%) had mood disorders, 2(6.25%) were epileptic.Conclusions: This study of suicides of young adults will be quite helpful to psychiatrist and medico-social workers to take preventive measures to prevents such suicides because suicide is not only social problem, but it is due to abnormal mental state too.
A study of effect of low dose atorvastatin therapy on high sensitivity C-reactive protein in patients with modifiable and non-modifiable cardiovascular risk factors in central India
Authors: Verma Archana , Chandra Umesh Kumar , Verma Sandhya , Jhavar Dharmendra , Badole Shivshankar 
Published: November 2019

Background: Anti-inflammatory effects of statins have generated maximum interest, as has been demonstrated in a number of studies showing rapid decrease in CRP levels in patients of acute coronary syndromes. This CRP lowering property of statins has also translated into clinical benefits as suggested by reduction in rate of recurrent angina, recurrent myocardial infarction, and mortality.Methods: This prospective, open, and controlled study was conducted on 160 indoor and outdoor patients, for total duration of two years (2005-2006), in GMC Bhopal, MP, India.Results: In all the four groups, baseline serum hs-CRP was statistically significant (p value <0.01) higher than normal hs-CRP level. Mean reduction (%) in hs-CRP after 3 months of statin therapy was 83.6% in group A and 62.4% in group C which is highly significant (p value <0.001). In group B also, 26% hs-CRP reduction was noticed which is statistically significant (p value <0.01). Baseline hs-CRP was statistically significant high (p value <0.01) in hypertensive patients. Percentages reduction in group A (87%) and group C (66%) was statistically significant (p value <0.01). Baseline hs-CRP was statistically significant higher (p value <0.01) than normal population. After 3 months of statin therapy percentage reduction in group A and group C was statistically significant (p value <0.01). Conclusions: Low dose atorvastatin can significantly reduce CRP level in patients with risk factors for cardiovascular disease. Early initiation of low dose atorvastatin can reduce this inflammatory marker in both ACS and high risk for ACS patients and can prevent major adverse cardiac events.
Thyroid profile in type 2 diabetes mellitus
Authors: Dave Mahesh , Saini Hazari Lal , Gupta Ankit , Choudhary Jitendra Singh , Burli Aniruddha 
Published: November 2019

Background: Diabetes mellitus is an endocrine disorder which involves multiple organ systems and leads to significant morbidity and mortality. Diabetes mellitus has been defined as “A metabolic syndrome characterized by chronic hyperglycemia and disturbance of carbohydrate, fat and protein metabolism associated with absolute or relative deficiency in insulin secretion and or insulin action”. Thyroid diseases are also a common endocrinopathy seen in the adult population. Thyroid hormones are intimately involved in cellular metabolism. The present work is a modest attempt to study the prevalence of thyroid disorders in patients with type 2 diabetes mellitus.Methods: The study was carried out in total 108 diabetic patients without known thyroid disorder admitted in various Medical wards of R.N.T. Medical college and attached group of hospitals, Udaipur. It was a cross Sectional study done over a period of 10 months. Results: In the present study, 13% of patients with type 2 diabetes mellitus had abnormal thyroid profile. Out of which the most common presentation was sub clinical hypothyroidism found in 9.25% followed by1.9% had overt hypothyroidism and 1.9% had sub clinical hyperthyroidism. In persons with abnormal thyroid profile 85.7% were females and 14.3% were males which was statistically significant.Conclusions: Prevalence of thyroid dysfunction is common among T2DM patients and is higher in females than in males. There is no significant correlation between thyroid dysfunction and age, diabetes control, family history, type of treatment and HbA1c level in diabetic patients.
Evaluation of omalizumab at certain time intervals in patients with chronic spontaneous idiopathic urticaria
Authors: Kutlu Ömer , Karaarslan Engin , Karaosmanoğlu Nermin , Ekşioğlu Hatice Meral 
Published: November 2019

<p class="abstract"><strong>Background:</strong> In this study, we aimed to evaluate the response of patient treated with omalizumab at certain time intervals through 6 months with pruritus visual analog scale, urticaria activity score and quality of life indexes.</p><p class="abstract"><strong>Methods:</strong> The study was performed on ten patients diagnosed with chronic idiopathic spontaneous urticaria. The disease was assessed by the Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL) and Dermatology Life Quality Index (DLQI) for every 2 weeks while was assessed by Urticaria Activity Score (UAS-7) and Pruritus Visual Analog Scale (PVAS) for once a week during the 6-month treatment period. Statistical significance was evaluated using the Mann-Whitney <em>U</em> test in SPSS 20. </p><p class="abstract"><strong>Results:</strong> Pre-treatment values of the DLQI, CU-Q2oL, UAS-7, and PVAS was statistically higher than post-treatment values of these indexes (p&lt;0.05). The mean DLQI/ CU-Q2oL value of the patients before treatment was 17±6.09/ 52.87±22.07 while it was 19.4±16.36 at the end of 2nd-week post-injection per month, and was 21.85±16.56 at the end of 4nd-week post-injection per month during 6-months following. Statistically, PVAS score at the fourth week was higher than 2nd and 4th week (p&lt;0.042, p&lt;0.007).</p><p><strong>Conclusions:</strong> In this study, it was detected that omalizumab had a significant effect on DLQI, CU-Q2oL, UAS-7, PVAS scores in CISU. It can be concluded that significant increase of PVAS score at 4th week compared to scores at 2nd and 3rd week may necessitate the use of omalizumab combined with antihistamines at 4th week of the treatment.</p>
Inhibitory effects of different hand sanitizers against the resident microflora of skin
Authors: Ishma Touhida , Uddin H. M. Sayeed , Paul Anik , Feroz Farahnaaz , Acharjee Mrityunjoy 
Published: November 2019

<p class="abstract"><strong>Background:</strong> Practice of hand washing is very important to eliminate the microbial contamination especially during the work in laboratories, hospital and even at home before taking food. Proper use of hand sanitizer can significantly reduce the rate of hospital acquired infection also.</p><p class="abstract"><strong>Methods:</strong> The current investigation was designated to identify different bacterial species from the upper skin of hands of the laboratory managements through conventional culture methods and the efficacy of the samples (Dettol, Purell and Savlon) against the isolated bacteria through agar well diffusion method and minimum inhibitory concentration (MIC) </p><p class="abstract"><strong>Results:</strong> Different concentrations such as 25%, 50% and 100% of each of antimicrobial agents showed their antibacterial activity against <em>Staphylococcus </em>spp., <em>Klebsiella </em>spp., <em>E. coli</em> and <em>Pseudomonas</em> spp. those were isolated from the hand. 25% of Dettol exhibited 20 mm zone diameter against <em>Klebsiella</em>spp. Whereas 25% of Purell and Savlon unveiled 15 mm and 22 mm zone of inhibition against <em>E. coli</em> and <em>Pseudomonas</em> spp. respectively. In case of 100% sample of Dettol, Purell and Savlon, the highest zone diameter was observed as 55 mm, 50 mm and 45 mm against <em>Klebsiella </em>spp.,<em> Staphylococcus </em>spp., and <em>E. coli</em> consecutively. The MIC of Dettol sample was 8 µl against <em>Staphylococcus </em>spp., and <em>Pseudomonas</em> spp. In case of Purell, the MIC was 128 µl against <em>Staphylococcus</em> spp., <em>Klebsiella </em>spp. and <em>Pseudomonas </em>spp. were inhibited at 4 µl samples.</p><p class="abstract"><strong>Conclusions:</strong> The in-vitro antibacterial activity of the hand sanitizers was so satisfactory against the isolated bacteria. This finding would be very helpful for the laboratory management in order to minimize the rate of contamination during the research and supervision of the different experiment.</p>
Blood donation: a comparison between medical students and non-medical students
Authors: Musa Muneer M. , Shaaban Kamil M. 
Published: November 2019

<p class="abstract"><strong>Background:</strong> Voluntary blood donation represents the main source of blood in Sudan. While students are a potential source of blood, this study aim to address the knowledge, attitudes, barriers and motives of both medical and non-medical students in order to recruit them for donating blood to meet the demands of the patients.</p><p class="abstract"><strong>Methods:</strong> A facility based descriptive cross-sectional study was conducted at Khartoum University between January and March 2019. Structured self-administered questionnaire was used to collect data from the participants. The Data were analyzed by the Statistical Package for Social Science software version 23. </p><p class="abstract"><strong>Results:</strong> Of the total 308 students, 75% were medical students and 25% were non-medical. Only 34 (11%) had ever donated blood. 97.1% don’t donate regularly. 79.4% of the donations were voluntary. Males were significantly more donors than females (p value=000). Students had poor knowledge about blood donation requirements but demonstrated better knowledge regarding blood borne diseases. More medical students knew their blood group than non-medical students. Not being asked to be the most reported reason for not donating blood (55.1%). Most of the donors reported that a relative or a friend needs blood was their motivation factor to donate blood (64.7%).</p><strong>Conclusions:</strong>Information about blood donation services and requirements should be available to the students. In addition, campaigns and educational sessions regarding the safety and demands of blood donation is crucial to address the fears and recruit students as eligible source of blood<p class="abstract"> </p>
Ghee: the much maligned cooking medium, now slowly reclaiming its therapeutic reputation
Authors: Bali Sharadendu , Utaal Maneshwar Singh 
Published: November 2019

<p>Ghee or clarified butter has been gloriously extolled for its virtues in Ancient Indian Medical Systems. For thousands of years, ghee was the cooking medium of choice in North Indian homes, and was also severally used as a drug carrier for delivering phytonutrients and lipid-soluble phytochemicals from herbs. The onset of cardio-vascular diseases in the industrial era brought the focus on cholesterol and saturated fatty acids as causative agents, and led to the sudden and dramatic decline in the use of ghee in Indian homes, beginning 1970s. The recent removal of the daily restrictions imposed on cholesterol by the FDA has reversed the derogatory narrative against cholesterol and cholesterol-rich fats like ghee. There is need to study the various properties of Ghee in a new light, including its role as a carrier for hydrophobic phyto-nutraceuticals and also as a cardio-protective agent.</p>
Non Salicylate-Associated Reye Syndrome: A Case Report
Authors: Azizi Arsalan , Sedaghattalab Moslem 
Published: November 2019

Reye's syndrome (RS) is a rare disease, usually associated with consumption of salicylates during viral illness. In 1965, the first case of association between RS and salicylates was described in United Kingdom (UK). The incidence of RS decreased dramatically after warnings of UK and US health agencies against using aspirin in children. Patients with RS presented with neurologic compromise, cerebral edema, acute hepatitis, and liver failure-especially in the children. In this paper, a four-month-old boy with diagnosis of RS was described, who presented with malaise, cyanosis and decreased level of consciousness, but the history of salicylates consumption was negative for him and his mother.
© 2019 Tehran University of Medical Sciences. All rights reserved.
Acta Med Iran 2019;57(5):332-334.
Pertinencia del tamizaje genético en donantes de gametos
Authors: Serrano-Serrano Claudia J. 
Published: November 2019

Introducción: una preocupación importante para las parejas sometidas a tratamientos de reproducción asistida con gametos donados es la posibilidad de adquirir enfermedades infecciosas o la transmisión de enfermedades genéticas a la descendencia. Existen reportes, basados en la legislación de cada país y en la experiencia de cada centro, que hacen referencia al tipo de evaluación genética, infecciosa y psicológica que deben tener los donantes de gametos. En Colombia no existe una ley específica sobre las técnicas de reproducción asistida y la donación de gametos. Tampoco existe claridad acerca de si los donantes deberían ser evaluados genéticamente y con qué tipo de pruebas.Objetivo: el objetivo de este documento es hacer una reflexión sobre la pertinencia de evaluar genéticamente a los donantes de gametos a partir de la caracterización de las principales condiciones genéticas prevalentes en nuestra población, la alteración genética de base y el método actual de diagnóstico genético.Conclusión: se concluye que es necesario desarrollar un protocolo claro a nivel nacional y en los centros de reproducción asistida a cerca de la evaluación genética en los pacientes donantes de gametos.
Sistem Prediksi Jumlah Permintaan Produk Darah Menggunakan Metode Least Square Regression Line (Studi Kasus : Utd Pmi Kabupaten Jombang)
Authors: Nasyika Dzurrotun , Slamin Slamin , Pandunata Priza 
Published: November 2019

Blood Transfusion Unit (UTD) as the provider of blood supply is required to fulfill blood demand. However in reality, the blood stock does not always meet the demand for blood. The amount of blood group stock in UTD depends on blood donors who voluntarily donate blood. Red blood cells only have a life span of 35 days since they were donated, if they have passed that time the blood cannot be used for transfusion. Based on these problems, the authors applied the Lesat Square Regression Line method to predict the number of requests for blood products in the coming month. The calculation results obtained prediction of demand with the smallest MAPE value that is blood product of PRC blood type A with a value of 14.40%. The biggest MAPE value obtained is 180.66% for WB blood type AB. Factors or parameters that affect the amount of blood product demand, that is the environment, disease outbreaks and differences in body resistance of each blood group. In addition, the types of blood products also have a number of different requests depending on the level of blood needs for health.
OPTIMASI PERSEDIAAN MATERIAL TRANSFORMATOR MENGGUNAKAN METODE JARINGAN SYARAF TIRUAN DAN ANT COLONY OPTIMIZATION DI PT. PLN (PERSERO) AREA JEMBER
Authors: Herdatullah Rizki , Bukhori Syaiful , Retnani Windi Eka Yulia 
Published: November 2019

Optimization comes from basic words optimal which mean the best, highest, most beneficial, make the best, and do optimizing (make the best, highest, etc.). Forecasting is an attempt to predict the future. Prediction can be done by studying the pattern of historical data to find a model that can show future data. This methoed is called time series data forecasting. One of many algorithm that can builds model from historical data is Artificial Neural Networks (ANN). The algoritm mimics the human neuron system so that is can solve non-linear problems, such as the forecasting of transformator demand.
In the process of modeling, ANN will always update the connection weights to find the optimum weights. In this final project ANN will be trained by Ant Colony Optimization (ACO). Based on the results can be seen that ANN with ACO as learning methods can predict transformator demand with good result.
Increased Use Value of Coffee Bean Skin Waste as Liquid Fertilizer in Sukorambi Jember Area
Authors: Faizin Nur 
Published: November 2019

The Faculty of Engineering's community service program, University of Jember, with a partner, the Sumber Kembang Kelompok Tani (Farmer Group), aims to overcome partner problems, about the accumulation of coffee bean skin waste that is not utilized. So far, the Sumber Kembang Kelompok Tani (Farmer Group) has not utilized coffee waste properly. The waste of the coffee bean skin will be processed into liquid fertilizer. The community service team will act as a facilitator and instructor in training or mentoring, which includes: 1. Explanation of the use and method of making liquid fertilizer from coffee bean skin, 2. Training related to the use of tools and processes for making liquid fertilizer, 3. Monitoring activities after socialization and training. The results of this training and service are that farmers have the ability to make liquid organic fertilizer from coffee bean skin waste expected to increase partners' understanding in processing coffee bean skin waste into liquid fertilizer and adding economic value from coffee bean skin waste so that it has a higher selling value.
Coffee Processed Product Innovation in Kampung Pelita Bondowoso
Authors: Wildana Dina Tsalist , Furqoni Laili 
Published: November 2019

Bondowoso has been known as a city of tape. This district also has the potential of coffee plantations that have produced products until it is known as the Republic of Coffee. The purpose of this activity is to increase public knowledge about various kinds of processed coffee, provide value added products, and attract consumers to come to visit the region. The method used is trial and error and utilizes the University of Jember Real Lecture Program where the target area is Sub-District Tamansari, Bondowoso District, Bondowoso Regency. The results of the activities include the emergence of innovations in processed coffee products such as: coffee dawet, coffee marrow porridge, Cilok Kopi, coffee fried rice and coffee ladrang. This activity was supported by PKK ladies and received support from Blue Gas. Such innovation activities are quite interesting for the community because they are able to make various kinds of processed foods from coffee. It&#39;s just that more intensive training is needed so that these processed products can support Bondowoso tourism.