bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing Effect of Auricular Acupressure and Body Acupressure on Pain and Duration of First Stage of Labor: Study Protocol for a Randomized Controlled Trial
Authors: Alimoradi Zainab , Kazemi Farideh , Valiani Mahboubeh , Gorji Maryam 
Published: November 2019

Abstract
Background Labor pain is one of the leading causes for fear of childbirth. Acupressure is a non-pharmacological pain relief method which showed promising results. Comparing the effect of body acupressure at multiple points and auricular acupressure on the pain and duration of labor, the present study is designed. Methods/Design In a randomized controlled trial, 90 primigravida women who attend for childbirth would be randomly assigned to three groups (interventions: body acupressure and auricular acupressure, control: routine care). In order to determine the allocation sequence with 1:1:1 ratio, the computer-generated 6-block randomization techniques would be used. To hide the allocation, the type of intervention will be written based on the generated sequence and put in opaque enveloped pockets; then, the pockets as well as questionnaires are encoded respectively. The pain score of all the participants would be measured at the peak uterine contraction at the 4cm cervical dilation and at 10 cm dilation based on visual analog scale (VAS). Duration of the active phase of labor in these groups are recorded too. Data are imported into SPSS-16 software. First, normality of the data distribution will be investigated. To compare the labor duration among the research groups, ANOVA would be used, which will be followed, in case of significance, by the Scheffe post-hoc test. Furthermore, Chi-squared test would be used to compare the categorized demographic variables and ANOVA or Kruskal-Wallis tests will be used to compare the quantitative variables in the studied groups. significance level of 0.05 is considered significant. Discussion In this study the effect of auricular acupressure and body acupressure on pain and duration of first stage of labor will be compared.
Seven-day services in surgery and weekend effect at a Japanese teaching hospital: a retrospective cohort study
Authors: Matoba Masaaki , Suzuki Takashi , Ochiai Hirotaka , Shirasawa Takako , Yoshimoto Takahiko , Minoura Akira , Sano Hitomi , Ishii Mizue , Kokaze Akatsuki , Otake Hiroshi , Kasama Tsuyoshi , Kamijo Yumi 
Published: November 2019

Abstract
The authors have withdrawn this preprint from Research Square
Willingness to adopt wearable devices with behavioral and economic incentives by health insurance wellness programs: results of a US cross-sectional survey with multiple consumer health vignettes
Authors: Soliño-Fermández Diego , Ding Alexander , Bayro-Kaiser Esteban , Ding Eric L. 
Published: November 2019

Abstract
Background: The number of health-related wearable devices is growing but it is not clear if Americans are willing to adopt health insurance wellness programs based on wearables and the incentives with which they would be more willing to adopt. Methods: In this cross-sectional study we used a survey methodology, usage vignettes and a dichotomous scale to examine U.S. residents’ willingness to adopt wearables (WTAW) in six use-cases where it was mandatory to use a wearable device and share the resulting data with a health insurance company. Each use-case was tested also for the influence of additional economic incentives on WTAW. Results: A total of 997 Americans across 46 states participated in the study. Most of them were 25 to 34 years old (40.22%), 57.27% were female, and 74.52% were white. On average, 69.5% of the respondents were willing to adopt health-insurance use-cases based on wearable devices, though 77.8% of them were concerned about issues related to economic benefits, data privacy and to a lesser extent, technological accuracy. WTAW was 11-18% higher among consumers in use-cases involving health promotion and disease prevention. Furthermore, additional economic incentives combined with wearables increased WTAW overall. Notably, financial incentives involving providing healthcare credits, insurance premium discount, and/or wellness product discounts had particularly greater effectiveness for increasing WTAW in the consumer use-cases involving participation: for health promotion (RR=1.06 for financial incentive, 95% CI: 1.01-1.11; P=0.018); for personalized products and services (RR=1.11 for financial incentive, 95% CI: 1.01-1.21; P=0.018); and for automated underwriting discount at annual renewal (RR=1.28 for financial incentive, 95% CI: 1.20-1.37; P<0.001). Conclusions: Under the adequate economic, data privacy and technical conditions, 2 out of 3 Americans would be willing to adopt health insurance wellness programs based on wearable devices, particularly if they have benefits related to health promotion and disease prevention, and particularly with financial incentives. Keywords: Diffusion of innovation; wearable electronic devices; health insurance; United States
Risk of multi-drug resistant Campylobacter spp. and residual antimicrobials at poultry farms and live bird markets in Bangladesh
Authors: Neogi Sucharit Basu , Islam Md. Mehedul , Islam SK Shaheenur , Akhter A.H.M. Taslima , Sikder Md. Mahmudul Hasan , Yamasaki Shinji , Kabir S. M. Lutful 
Published: November 2019

Abstract
Background: This study systematically examined potential risks and associated socio-environmental factors of MDR Campylobacter spp. in poultry farms and live bird markets (LBMs) of Bangladesh. Methods: Microbial culture and PCR-based methods were applied to examine the occurrence and MDR patterns of Campylobacter spp. at hatcheries (n = 33), broiler farms (n = 122) and LBMs (n = 69). Antimicrobial residues in broiler meat and liver samples (n = 50) were detected by advanced chromatographic techniques. A questionnaire based cross-sectional survey was conducted on socio-environmental factors. Results: In poultry farms, Campylobacter spp. was primarily found in cloacal swab (21/49, 43%), followed by drinking water (8/24, 33%), and meat (8/28, 29%) samples of broilers. Remarkably, in live bird markets, Campylobacter spp. was detected in higher prevalence in broiler meat (14/26, 54%), which could have an association with bacterial contamination in drinking water sources (11/21, 52%) and floor (9/21, 43%). Representative isolates (n = 71) were differentiated into two species: Campylobacter jejuni (66%) and Campylobacter coli (34%). Majority of C. jejuni (33/47, 70%) and C. coli (14/24, 58%) strains were observed to be MDR, predominantly showing resistance to amoxycilin, tetracycline and erythromycin, and additionally to ciprofloxacin, norfloxacin, streptomycin, and azithromycin. Residual antimicrobials, including oxytetracycline, ciprofloxacin and enrofloxacin, were detected in majority of broiler liver (79%) and meat (62%) samples. Alarmingly, 33% and 19% of the liver and meat samples, respectively, contained residual antimicrobial concentration above acceptable limit. Inadequate personal and environmental hygiene, unscrupulously use of antimicrobials, improper waste disposal, and lack of health surveillance and quarantine facilities of diseased birds were distinguishable anthropogenic risk factors, with local diversity and compound influences on MDR pathogens. Conclusion: The observed large-scale occurrence of MDR C. jejuni and C. coli and residual antimicrobials in poultry value chain reflects an alarming situation for public health in Bangladesh. Potential contamination sources of MDR Campylobacter and the combined influences of diverse socio-environmental risk factors, noted in this study, would aid in developing interventions to minimize the increasing risks of poultry-associated MDR pathogens under ‘One Health’ banner that includes poultry, human and environment perspectives.
The trend of full vaccination coverage in infants and inequalities by wealth quintile and maternal education: Analysis from four recent Demographic and Health Surveys in Nepal
Authors: Acharya Kiran , Paudel Yuba Raj , Dharel Dinesh 
Published: November 2019

Abstract
Background Despite policy intention to reach disadvantaged populations, inequalities in child health care use and health outcomes persist in Nepal. The current study aimed to investigate the trend of full vaccination coverage among infants and its equity gaps between Nepal Demographic and Health Surveys (NDHS) 2001 and 2016.Methods Using data from NDHS conducted in 2001, 2006, 2011 and 2016, we investigated the trend of coverage of six antigens:Bacille Calmette Guerin (BCG), Diptheria, Pertussis, Tetanus (DPT), Polio, and Measles during their infancy among children aged 12-23 months. We presented trends and correlates of vaccination coverage by different socio-demographic factors. We measured inequalities in full vaccination coverage by wealth quintile and maternal education using absolute measure (slope index of inequality) and relative measures (Relative index of inequality, concentration index) of inequalities.Results Full immunization coverage among infants steadily increased from 65.6% in 2001 to 87.0% in 2011; however, it decreased to 77.8% in 2016. Province 2 had a significantly lower full vaccination coverage compared to Province1.Although decreasing over time, there were significant inequalities by household wealth quintiles and maternal educational status. The slope index of inequality (SII) for wealth quintiles decreased from -32.3 [-45.5,-19.1] in 2001 to an SII of-8.4 [-18.6,-1.7] in 2016. Similarly, the SII for education decreased from -61.8 [-73.5,-50.1] in 2001 to an SII of -30.5 [-40.7,-20.2] in 2016. Similarly, the relative index of inequality (RII) also showed an improvement over time, indicating the narrowing equity gap. Additionally, concentration index on full immunization coverage by wealth quintiles dropped from 0.21 (0.12-0.28) in 2001 to 0.054 (-0.01-0.12) in 2016. Absolute and relative inequalities were persistently larger by maternal educational status compared to household wealth quintiles throughout the study period.Conclusion Full vaccination coverage in Nepal increased from 2001 until 2011 but saw a significant decrement away from the national target after 2011. However, the equity gap by household wealth quintile and maternal education status has narrowed over time. However, immunization programs need to give higher emphasis to infants born to mothers with less education, those born in the poorer wealth quintile households, and those living in Province 2.
Determinants of late antenatal care follow up among pregnant women in Easter zone Tigray, Northern Ethiopia, 2018. Unmatched case- control study
Authors: Gebremariam Gebrehiwot , Teklehaimanot Berhane Fseha , Gebru Hirut Teame , Gebrezgi Znabu Asfaw , Tekola Kidanemaryam Berhe , Baraki Mulu Ftiwi 
Published: November 2019

Abstract
Objective: The purpose of the study was to identify determinants of late antennal care at first visit in health facilities of eastern zone of Tigray, Northern Ethiopia 2018. Result: Women with unplanned pregnancy (AOR= 4.03, 95%, CI: 1.56-5.67), Participants whose previous first antenatal care was after 16 weeks (AOR= 3.9, 95% CI: 1.98-7.68), Participants did not accompanied by their partner for antenatal visit (AOR= 1.29,95%, CI: 1.05-4.67), women recognized their current pregnancy at three months or late ( AOR= 4.7,95%,CI: 2.49-9.04) and participants provided adequate time for their previous antenatal care by health professionals ( AOR = 0.461, 95% CI 0.342- 0.875) were found the determinant factors of late antenatal care at first Visit. Hence family planning utilization, times of first visit antenatal, information flow and supporting by partners have a great role in improving antenatal care at first visit. There for responsible bodies should give focuses on utilization of family planning, increasing awareness of pregnancy symptoms and health provisional provide adequate time during visits.
Whole Exome Sequencing in Idiopathic Short Stature: rare mutations affecting growth
Authors: Noorian Shahab , Rohani Farzaneh , Savad Shahram , Kabir Kourosh , Khonsari Nami Mohammadian , Ghanipour Nima , Gholami Mehri , Zaimkohan Hooshang 
Published: November 2019

Abstract
Introduction: one of the most common causes of referrals to paediatricians is short stature (ISS), some pathogenic mutations may present exactly similar to non-pathogenic causes, our goal is to identify and treat these patients labelled ISS with these mutations and hopefully treat them correctly. Materials and Methods: We assessed All children under the age of fifteen years labelled as ISS. Fourteen of them were confirmed to be ISS and thus were allowed in our study. Afterwards, we pooled their blood specimens and ordered a whole-exome sequencing (WES) test. Results: five patient had normal WES results. Four patients had rare motions that were not studied in the previous literature but due to the functions of the genes, and our patients’ phenotypes it is highly possible that these mutations caused our patients’ short stature. Four patients had known genetic mutations causing short stature. One patient had a mutation with no effect on height. With the help of WES, some rare mutations were found, with the patients’ phenotype and evaluation we identified their function, we diagnosed some other patients’ rare genetic disorders and assessed the possible effect of their mutation on their height and phenotype we aimed to determine how many children labelled as ISS are correctly diagnosed. By WES most of our patient achieved the correct diagnosis which would be impossible to diagnose without WES; thus the reason for their short stature was identified, with the correct diagnosis now we can aim for the proper treatment.
Factors associated with seeking post-abortion care among women in Guangzhou, China
Authors: Wang Hui , Liu Yan , Xiong Ribo 
Published: November 2019

Abstract
Background: Post-abortion care(PAC) service in China relies on integrating post-abortion family planning (PAFP) services into existing abortion services in hospital settings where the vast majority of induced abortion is performed. This study aims to assess post-abortion care (PAC) utilization and identify factors affecting PAC uptake among clients on the day of abortion in Guangzhou, China. Methods: A cross-sectional study was conducted involving a total of 423 abortion clients in the selected hospitals of Guangzhou From June to September, 2018. The anonymous, self-reported questionnaires regarding associated factors were administered to all participants. Multivariate logistic regression model was used to determine associated factors of PAC utilization. Results: The magnitude of PAC counseling before they leave the health care facilities was 42.1%. Multivariate logistic regression showed that unmarried women, women with local household registration, knowing fertility could return sooner after abortion and women themselves as the main decider on PAC use were significantly associated with PAC utilization. Conclusions: The utilization rate of PAC was low in Guangzhou, China. There’s an urgent need to improve the awareness of regular use of PAC and provide better access for migrants. Partners should be involved during counseling after obtaining women’s consent. Women empowerment through enhancing health education on own decision making in PAC utilization should also be strengthened.
Neutrophil Count as a Reliable Marker of Diabetic Kidney Disease in Autoimmune Diabetes
Authors: Yu Yao , Lin Qiuqiu , Ye Dewei , Wang Yanfei , He Binbin , Li Yanhua , Huang Gan , Zhou Zhiguang , Xiao Yang 
Published: November 2019

Abstract
Background A growing body of evidence supports neutrophils as an active player in the development of diabetic kidney disease (DKD). However, the clinical relevance of neutrophils and DKD in autoimmune diabetes remains unknown. This study aims to investigate the relationship between circulating neutrophils and DKD in autoimmune diabetes.Methods Patients with type 1 diabetes (T1D, n=226) and latent autoimmune diabetes in adults (LADA, n=79) were enrolled and stratified according to the urinary albumin to creatinine ratio (ACR). Circulating levels of white blood cells (WBCs), including neutrophils, were measured in a central laboratory, and the neutrophil-to-lymphocyte ratio (NLR) was calculated. The risk factors associated with DKD were analysed by logistic regression.Results In T1D and LADA patients, the peripheral neutrophil counts increased in parallel with DKD advancement. The neutrophil counts in the patients with macroalbuminuria were significantly higher than those in the patients with normoalbuminuria for each type of diabetes. Furthermore, neutrophil counts positively correlated with the ACR. In addition, neutrophils were independently associated with DKD in T1D in the logistic regression analysis, when various well-known risk factors, including disease duration, sex, and smoking status, were adjusted as continuous variables.Conclusions Neutrophil counts are closely associated with DKD in patients with autoimmune diabetes, suggesting neutrophil-mediated inflammation may be involved in the pathogenesis of DKD in patients with autoimmune diabetes.
The procurement and supply chain strengthening project: Improving public health supply chains for better access to HIV medicines, Uganda 2011-2016
Authors: Muyingo Sowedi , Etoori David , Lotay Paul , Malamba Samuel Sewava , Olweny James , Keesler King , Jjemba Pito , Settaala Rashid 
Published: November 2019

Abstract
With countries moving towards reaching the UNAIDS 90-90-90 goal to achieve HIV epidemic control, there are going to be an unprecedented number of persons tested, treated, and regularly monitored for viral suppression. However, most of the countries with the greatest burden of HIV/AIDS experience regular stock outages which could be detrimental to reaching these targets. Antiretroviral therapy and other commodities such as HIV test kits and laboratory supplies need to be readily and consistently available in order to achieve these targets.
Medical Access Uganda Limited implemented several interventions as part of a procurement and supply chain strengthening project with the ultimate goal of supply chain improvement for access to HIV medicines. These interventions were evaluated using performance-monitoring-indicators from 2011-2016. We tested for the significance in the change in scores of performance-monitoring-indicators using the test for difference in proportions. Health facilities were scored on six categories and accredited as bronze, silver, or gold based on their total scores. Kaplan Meier estimates were computed for time to silver and gold ranking and Cox proportional hazards models were computed for time to gold ranking.
The 13 sites with a baseline score <50 achieved a final score of (Unranked=0,Bronze(50-69)=2,Silver(70-89)=8,Gold(≥90)=3), 44 sites with a baseline score 50-69 achieved a final score of (U=0,B=0,S=26,G=18), 106 sites with a baseline score 70-89 achieved a final score of (U=0,B=3,S=62,B=41) and 31 sites with a baseline score ≥90 achieved a final score of (U=0,B=1,S=10,G=20). We observed a significant reduction in reported stock outs from 46%-4% (p<0.001). Accurate stock card inventory rose from 79%-91% (p<0.001); adequate stock levels from 54%-71% (p=0.002) and stock reporting rates from 91%-100% (p<0.001). The stock order fill rate improved from 93%-97% (p=0.375). Patient load (medium vs low adjusted hazard ratio (aHR):2.19,p=0.026; high vs low aHR:2.97,p=0.034) and number of support supervision visits (6-10 aHR:3.33,p=0.024; >10 aHR:5.78,p= 0.003) were associated with better stock management ranking scores.
Improvements in supply chain management in countries committed to achieving the 90-90-90 goals are crucial to achieving HIV epidemic control. Health system strengthening and mentorship investments in Uganda were feasible and are essential for sustainable disease control efforts.
DNA barcode trnH-psbA is a promising candidate for efficient identification of forage legumes and grasses
Authors: Loera-Sánchez Miguel , Studer Bruno , Kölliker Roland 
Published: November 2019

Abstract
Objective Grasslands are widespread ecosystems that fulfil many functions. Plant species richness (PSR) is known to have beneficial effects on such functions and monitoring PSR is crucial for tracking the effects of land use and agricultural management on these ecosystems. Unfortunately, traditional morphology-based methods are labor-intensive and cannot be adapted for high-throughput assessments. DNA barcoding could aid increasing the throughput of PSR assessments in grasslands. In this proof-of-concept work, we aimed at determining which of three plant DNA barcodes ( rbcLa , matK and trnH-psbA ) best discriminates 16 key grass and legume species common in temperate sub-alpine grasslands. Results Barcode trnH-psbA had a 100% correct assignment rate (CAR) in the five analyzed legumes, followed by rbcLa (93.3%) and matK (55.6%). Barcode trnH-psbA had a 100% CAR in the grasses Cynosurus cristatus , Dactylis glomerata and Trisetum flavescens . However, the closely related Festuca, Lolium and Poa species were not always correctly identified, which led to an overall CAR in grasses of 66.7%, 50.0% and 46.4% for trnH-psbA , matK and rbcLa , respectively. Barcode trnH-psbA is thus the most promising candidate for PSR assessments in permanent grasslands and could greatly support plant biodiversity monitoring on a larger scale.
Spatial-temporal mapping of hand, foot and mouth disease in relation to climate factors in Xinjiang, China from 2008 to 2016
Authors: xie ling , Huang Ruifang , Wang Hongwei , Xiao Zhengqing 
Published: November 2019

Abstract
[Objectives]: The study mainly aims to depict the epidemiological characteristics of hand, foot and mouth disease (HFMD) in Xinjiang, China and evaluate the effects of meteorological factors (temperature & precipitation) on its dynamics through spatiotemporal analysis. This study provides substantial evidences for disease HFMD control and prevention.
[Methods]: With the data from the national surveillance data of HFMD and meteorological parameters in the study area from 2008 to 2016, the correlation between meteorological factors and HFMD incidence was explored through kernel density analysis. Furthermore, the spatial autocorrelation of HFMD in each year was analyzed by the Spatial Autocorrelation (Global Moran's I) tool.
[Results]: The relationship between monthly mean temperature (T) and HFMD cases fit best in the following logarithmic equation: y=4.8176ln(T)-19.773, (R2 = 0.5194). The relationship between monthly mean precipitation (P) and HFMD fit best in the following quadratic equation, y=-1E-06×P2+0.0108×P+5.9867, (R2 = 0.5319). HFMD was mainly distributed in northern Xinjiang. Global spatial autocorrelation analysis indicated the spatial dependency on the incidence of HFMD in 2008, 2010, 2012, 2014 and 2015. The spatial dependency is the negative spatial autocorrelation in 2009. The incidence of HFMD in Xinjiang presented a random distribution pattern in 2011 and 2016.
[Conclusion]: Our findings show that meteorological (air temperature & precipitation) variables had important effects on HFMD occurrence and transmission. This study provides a basis for the early warning of HFMD.