bluuebunny/crossref_metadata_2025_split huggingface dataset:
Out-of-plane capacity of cladding panel-to-structure connections in one-story R/C precast structures
Authors: Menichini Giovanni , Del Monte Emanuele , Orlando Maurizio , Vignoli Andrea 
Published: October 2020

AbstractThe interaction between cladding panels and the main structure is a crucial point to assess the seismic response, and above all the structural safety, of RC precast industrial building. In the past, connections were often designed to allow construction tolerances and to accommodate both thermal and wind-induced displacements. The lack of specific details to allow relative in-plane displacements between cladding panels and the main structure often led to the participation of cladding panels in the structure seismic-resistant system with consequent connection failures. In the last decades, a lot of experimental tests were performed to investigate the in-plane performance of panel connections, and some design recommendations have been developed accordingly. In the out-of-plane direction, the connections were often considered to be infinitely rigid and not to suffer any damage by the seismic load. This work deals with the out-of-plane response of panel-to-structure connections for vertical panels typical of industrial and commercial precast buildings. Both standard hammer-head strap and new devices, called SismoSafe, were investigated. Tests were performed in the Structures and Materials Testing Laboratory of the Department of Civil and Environmental Engineering of Florence, where a specific setup was designed to perform cyclic and monotonic tests on the connection devices. Standard connections showed a rather limited resistance, while the innovative connections exhibited a high out-of-plane resistance. Numerical analyses were also performed on a case study building to evaluate the distribution of the out-of-plane demand on the connections.
Rhizobactin B is the preferred siderophore by a novel Pseudomonas isolate to obtain iron from dissolved organic matter in peatlands
Authors: Kügler Stefan , Cooper Rebecca E. , Boessneck Johanna , Küsel Kirsten , Wichard Thomas 
Published: October 2020

AbstractBacteria often release diverse iron-chelating compounds called siderophores to scavenge iron from the environment for many essential biological processes. In peatlands, where the biogeochemical cycle of iron and dissolved organic matter (DOM) are coupled, bacterial iron acquisition can be challenging even at high total iron concentrations. We found that the bacteriumPseudomonassp. FEN, isolated from an Fe-rich peatland in the Northern Bavarian Fichtelgebirge (Germany), released an unprecedented siderophore for its genus. High-resolution mass spectrometry (HR-MS) using metal isotope-coded profiling (MICP), MS/MS experiments, and nuclear magnetic resonance spectroscopy (NMR) identified the amino polycarboxylic acid rhizobactin and a novel derivative at even higher amounts, which was named rhizobactin B. Interestingly, pyoverdine-like siderophores, typical for this genus, were not detected. With peat water extract (PWE), studies revealed that rhizobactin B could acquire Fe complexed by DOM, potentially through a TonB-dependent transporter, implying a higher Fe binding constant of rhizobactin B than DOM. The further uptake of Fe-rhizobactin B byPseudomonassp. FEN suggested its role as a siderophore. Rhizobactin B can complex several other metals, including Al, Cu, Mo, and Zn. The study demonstrates that the utilization of rhizobactin B can increase the Fe availability forPseudomonassp. FEN through ligand exchange with Fe-DOM, which has implications for the biogeochemical cycling of Fe in this peatland.
Identifying the weak spots in packaging paper: local variations in grammage, fiber orientation and density and the resulting local strain and failure under load
Authors: Lahti Jussi , Dauer Michael , Keller D. Steven , Hirn Ulrich 
Published: October 2020

AbstractMeasured local paper structure—i.e. local basis weight, local thickness, local density and local fiber orientation—has been linked to local strain and local material failure (local temperature increase due to energy dissipation upon fiber–fiber bond failure) measured during tensile testing. The data has been spatially linked through data map registration delivering several thousand$$1\times 1\,\hbox{mm}^2$$1×1mm2paper regions, each containing all measured properties. The relation between local paper structure and resulting local deformation and failure is studied with regression models. Multiple linear regression modeling was used to identify the paper structure related drivers for local concentrations of strain under load and local concentrations of material failure, which are both starting to occur considerably before rupture of the paper. Analyzing the development of local strain in paper we found that regions with higher basis weight and higher fiber orientation in load direction tend to exhibit considerably lower strain during tensile testing. Furthermore, the relation between local strain and local grammage can be predicted with the statistical theory of elasticity. Also regions with higher density have lower local strain, but not as pronounced. The findings for local fiber–fiber bond failure of paper are similar but not equivalent. The strongest correlation exists with local grammage. Local density and local fiber orientation show in turn weaker correlation with local bond failure. Local variations in paper thickness were not relevant in any case. These findings are highlighting the relevance of local fiber orientation and local density variations as structural mechanisms governing paper failure. In the past the focus has been mostly on paper formation. Together with local grammage (formation) they are responsible for the weak spots in paper, and thus cause local concentrations of paper strain and the initiation of failure under tensile load.
On the Equivalence Principle and Relativistic Quantum Mechanics
Authors: Trzetrzelewski Maciej 
Published: October 2020

AbstractEinstein’s Equivalence Principle implies that the Lorentz force equation can be derived from a geodesic equation by imposing a certain (necessary) condition on the electromagnetic potential (Trzetrzelewski, EPL 120:4, 2018). We analyze the quantization of that constraint and find the corresponding differential equations for the phase of the wave function. We investigate these equations in the case of Coulomb potential and show that physically acceptable solutions do not exist. This result signals an inconsistency between Einstein’s Equivalence Principle and Relativistic Quantum Mechanics at an atomic level.
Inflammation Triggered by SARS-CoV-2 and ACE2 Augment Drives Multiple Organ Failure of Severe COVID-19: Molecular Mechanisms and Implications
Authors: Iwasaki Masae , Saito Junichi , Zhao Hailin , Sakamoto Atsuhiro , Hirota Kazuyoshi , Ma Daqing 
Published: October 2020

Abstract
The widespread occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a pandemic of coronavirus disease 2019 (COVID-19). The S spike protein of SARS-CoV-2 binds with angiotensin-converting enzyme 2 (ACE2) as a functional “receptor” and then enters into host cells to replicate and damage host cells and organs. ACE2 plays a pivotal role in the inflammation, and its downregulation may aggravate COVID-19 via the renin-angiotensin system, including by promoting pathological changes in lung injury and involving inflammatory responses. Severe patients of COVID-19 often develop acute respiratory distress syndrome and multiple organ dysfunction/failure with high mortality that may be closely related to the hyper-proinflammatory status called the “cytokine storm.” Massive cytokines including interleukin-6, nuclear factor kappa B (NFκB), and tumor necrosis factor alpha (TNFα) released from SARS-CoV-2-infected macrophages and monocytes lead inflammation-derived injurious cascades causing multi-organ injury/failure. This review summarizes the current evidence and understanding of the underlying mechanisms of SARS-CoV-2, ACE2 and inflammation co-mediated multi-organ injury or failure in COVID-19 patients.
Left-to-Right Asymmetry and Early Association in Korean
Authors: Kiaer Jieun 
Published: October 2020

AbstractThis paper shows Korean speakers’ strong preference for incremental structure building based on the following core phenomena: (1) left–right asymmetry; (2) pre-verbal structure building and a strong preference for early association. This paper argues that these phenomena reflect the procedural aspects of linguistic competence, which are difficult to explain within non-procedural grammar formalisms. Based on these observations, I argue for the necessity of a grammar formalism that adopts left-to-right incrementality as a core property of the syntactic architecture. In particular, I aim to show the role of (1) constructive particles; (2) prosody; and (3) structural routines in incremental Korean structure building. Though the nature of this discussion is theory-neutral, in order to formalise this idea I will adopt Dynamic Syntax [DS: Kempson et al. (Dynamic syntax: the flow of language understanding, Blackwell, Oxford, 2001); Cann et al. (The dynamics of language. Elsevier, Oxford, 2005)] in this paper.
Safety and Tolerability of Manual Push Administration of Subcutaneous IgPro20 at High Infusion Rates in Patients with Primary Immunodeficiency: Findings from the Manual Push Administration Cohort of the HILO Study
Authors: Cowan Juthaporn , Bonagura Vincent R. , Lugar Patricia L. , Maglione Paul J. , Patel Niraj C. , Vinh Donald C. , Hofmann Jutta H. , Praus Michaela , Rojavin Mikhail A. 
Published: October 2020

Abstract
Purpose
To evaluate the safety and tolerability of IgPro20 manual push (also known as rapid push) infusions at flow rates of 0.5–2.0 mL/min.

Methods
Patients with primary immunodeficiency (PID) with previous experience administering IgPro20 (Hizentra®, CSL Behring, King of Prussia, PA, USA) were enrolled in the Hizentra® Label Optimization (HILO) study (NCT03033745) and assigned to Pump-assisted Volume Cohort, Pump-assisted Flow Rate Cohort, or Manual Push Flow Rate Cohort; this report describes the latter. Patients administered IgPro20 via manual push at 0.5, 1.0, and 2.0 mL/min/site for 4 weeks each. Responder rates (percentage of patients who completed a predefined minimum number of infusions), safety outcomes, and serum immunoglobulin G (IgG) trough levels were evaluated.

Results
Sixteen patients were treated; 2 patients (12.5%) discontinued at the 1.0-mL/min level (unrelated to treatment). Responder rates were 100%, 100%, and 87.5% at 0.5-, 1.0-, and 2.0-mL/min flow rates, respectively. Mean weekly infusion duration decreased from 103–108 to 23–28 min at the 0.5- and 2.0-mL/min flow rates, respectively. Rates of treatment-related treatment-emergent adverse events (TEAEs) per infusion were 0.023, 0.082, and 0.025 for the 0.5-, 1.0-, and 2.0-mL/min flow rates, respectively. Most TEAEs were mild local reactions and tolerability (infusions without severe local reactions/total infusions) was 100% across flow rate levels. Serum IgG levels (mean [SD]) were similar at study start (9.36 [2.53] g/L) and end (9.58 [2.12] g/L).

Conclusions
Subcutaneous IgPro20 manual push infusions at flow rates up to 2.0 mL/min were well tolerated and reduced infusion time in treatment-experienced patients with PID.

Trial Registration
NCT03033745
Anisotropic stress state and small strain stiffness in granular materials: RC experiments and DEM simulations
Authors: Goudarzy Meisam , Magnanimo Vanessa , König Diethard , Schanz Tom 
Published: October 2020

AbstractThe paper combines experimental and numerical analyses to study the relation between small strain stiffness and micro-structure of an idealized granular material under isotropic and anisotropic stress conditions. Results from the resonant column device on glass ballotini show that the relation between the maximum shear modulus and anisotropic stress components strongly depends on the applied stress path. Discrete element simulations (DEM) are performed to investigate the material behaviour along isotropic compression, triaxial compression and constant$$\hbox {K}_0$$K0deformation. The DEM analysis reveals that each stress path is associated with a characteristic evolution of the coordination number, i.e., the average number of contacts per particle. In turn, the maximum shear modulus is found to be a direct function of the coordination number. In order to include the micro-structure interpretation in the analytical description, a modified version of Hardin’s relation is proposed as a function of coordination number, void ratio and mean pressure.
Coupling simulation with artificial neural networks for the optimisation of HVAC controls in manufacturing environments
Authors: Mawson Victoria Jayne , Hughes Ben Richard 
Published: October 2020

AbstractManufacturing remains one of the most energy intensive sectors, additionally, the energy used within buildings for heating, ventilation and air conditioning (HVAC) is responsible for almost half of the UK’s energy demand. Commonly, these are analysed in isolation from one another. Use of machine learning is gaining popularity due to its ability to solve non-linear problems with large data sets and little knowledge about relationships between parameters. Such models use relationships between inputs and outputs to make further predictions on unseen data, without requiring any understanding regarding the system, making them highly suited to dealing with the stochastic data sets found in a manufacturing environment. This has been seen in literature for determining electrical energy demand for residential or commercial buildings, rather than manufacturing environments. This study proposes a novel method of coupling simulation with machine learning to predict indoor workshop conditions and building energy demand, in response to production schedules, outdoor conditions, building behaviour and use. Such predictions can subsequently allow for more efficient management of HVAC systems. Based upon predicted energy consumption, potential spikes were identified and manufacturing schedules subsequently optimised to reduce peak energy demand. Coupling simulation techniques with machine learning algorithms eliminates the requirement for costly and intrusive methods of data collection, providing a method of predicting and optimising building energy consumption in the manufacturing sector.
Modeling of Atmospheric-Pressure Dielectric Barrier Discharges in Argon with Small Admixtures of Tetramethylsilane
Authors: Loffhagen Detlef , Becker Markus M. , Czerny Andreas K. , Klages Claus-Peter 
Published: October 2020

AbstractA time-dependent, spatially one-dimensional fluid-Poisson model is applied to analyze the impact of small amounts of tetramethylsilane (TMS) as precursor on the discharge characteristics of an atmospheric-pressure dielectric barrier discharge (DBD) in argon. Based on an established reaction kinetics for argon, it includes a plasma chemistry for TMS, which is validated by measurements of the ignition voltage at the frequency $$f =86.2\, {\hbox{kHz}}$$

f
=
86.2

kHz

for TMS amounts of up to 200 ppm. Details of both a reduced Ar-TMS reaction kinetics scheme and an extended plasma-chemistry model involving about 60 species and 580 reactions related to TMS are given. It is found that good agreement between measured and calculated data can be obtained, when assuming that 25% of the reactions of TMS with excited argon atoms with a rate coefficient of $$3.0 \times 10^{-16}\, {\hbox{m}^3/\hbox{s}}$$

3.0
×

10

-
16

m
3

/
s

lead to the production of electrons due to Penning ionization. Modeling results for an applied voltage $${U}_{{\mathrm{a}},0} = 4\, {\hbox{kV}}$$

U

a
,
0

=
4

kV

show that TMS is depleted during the residence time of the plasma in the DBD, where the percentage consumption of TMS decreases with increasing TMS fraction because only a finite number of excited argon species is available to dissociate and/or ionize the precursor via energy transfer. Main species resulting from that TMS depletion are presented and discussed. In particular, the analysis clearly indicates that trimethylsilyl cations can be considered to be mainly responsible for the film formation.
US population norms for the EQ-5D-5L and comparison of norms from face-to-face and online samples
Authors: Jiang Ruixuan , Janssen M. F. Bas , Pickard A. Simon 
Published: October 2020

Abstract
Purpose
Normative scores (norms) allow for comparisons between population(s) of interest and the general population, which is useful for burden of disease studies and cost-effectiveness analysis. The primary aim of this study was to estimate US visual analogue scale (EQ VAS) and utility-based norms for the EQ-5D-5L using the face-to-face sample. The secondary aim was to compare norms estimated in the face-to-face and online populations.

Methods
This study estimated population norms from two general population surveys: (a) face-to-face and (b) online. In these surveys, respondents provided their health state using the EQ-5D-5L health classifier and the EQ VAS. Descriptive statistics, including mean, standard deviation (SD), 95% confidence interval, and median for the 5L utility and EQ VAS were estimated for each sample and across relevant respondent characteristics to serve as the basis for US EQ-5D-5L norms

Results
Face-to-face sample respondents (n = 1134) were representative of the US adult general population. In this sample, mean (SD) utility decreased with increasing age until age 45 or greater (age 45–54: 0.816 (0.249) age 55–64: 0.815 (0.243) age 65–74: 0.824 (0.217) age 75 + : 0.811 (0.218)). With increasing age, more problems were reported on all dimensions except anxiety/depression; a smaller proportion of respondents age 65 and older reported problems with anxiety/depression (23.8%) as compared to the youngest respondents (42.1%). Online (n = 2018) mean utility and EQ VAS values were consistently lower than the face-to-face sample.

Conclusions
The availability of US EQ-5D-5L norms facilitates interpretation and understanding of general population and patient health.
Does Migration Pay Off in Later Life? Income and Subjective Well-Being of Older Migrants in Europe
Authors: Gruber Stefan , Sand Gregor 
Published: October 2020

AbstractThis study examines whether intra-European migration pays off in terms of income and subjective well-being (SWB) for migrants aged 50 + who are now growing old abroad and in what way their SWB is associated with their relative income position. Using panel data from the Survey of Health, Ageing and Retirement in Europe allows us to go beyond the classical comparison with the native reference group and draw on information about respondents who stayed in the place of origin (‘stayers’). Our findings indicate that migration does pay off in later life. Compared to similar stayers, migrants have higher income and higher SWB levels. Furthermore, we find that older migrants’ SWB is positively associated with their relative income position for those with an income above the income of both stayers in the origin and natives in the destination country.
Establishment and triterpenoid production of Ocimum basilicum cambial meristematic cells
Authors: Mehring Alexander , Haffelder Janik , Chodorski Jonas , Stiefelmaier Judith , Strieth Dorina , Ulber Roland 
Published: October 2020

AbstractThe application of plant suspension culture to produce valuable compounds, such as the triterpenoids oleanolic acid and ursolic acid, is a well-established alternative to the cultivation of whole plants. Cambial meristematic cells (CMCs) are a growing field of research, often showing superior cultivation properties compared to their dedifferentiated cell (DDC) counterparts. In this work, the first-time establishment of O. basilicum CMCs is demonstrated. DDCs and CMCs were cultivated in shake flasks and wave-mixed disposable bioreactors (wDBRs) and evaluated regarding triterpenoid productivity and biomass accumulation. CMCs showed characteristic small vacuoles and were found to be significantly smaller than DDCs. Productivities of oleanolic and ursolic acid of CMCs were determined at 3.02 ± 0.76 mg/(l*d) and 4.79 ± 0.48 mg/(l*d) after 19 days wDBR cultivation, respectively. These values were consistently higher than any productivities determined for DDCs over the observed cultivation period of 37 days. Elicitation with methyl jasmonate of DDCs and CMCs in shake flasks resulted in increased product contents up to 48 h after elicitor addition, with the highest increase found in CMCs at 232.30 ± 19.33% (oleanolic acid) and 192.44 ± 18.23% (ursolic acid) after 48 h.
The P2X7 ion channel is dispensable for energy and metabolic homeostasis of white and brown adipose tissues
Authors: Tian Tian , Heine Markus , Evangelakos Ioannis , Jaeckstein Michelle Y. , Schaltenberg Nicola , Stähler Tobias , Koch-Nolte Friedrich , Kumari Manju , Heeren Joerg 
Published: October 2020

AbstractSeveral studies suggest a role of extracellular adenine nucleotides in regulating adipose tissue functions via the purinergic signaling network. Metabolic studies in mice with global deletion of the purinergic receptor P2X7 on the C57BL/6 background indicate that this receptor has only a minor role in adipose tissue for diet-induced inflammation or cold-triggered thermogenesis. However, recent data show that a polymorphism (P451L) present in C57BL/6 mice attenuates P2X7 receptor function, whereas BALB/c mice express the fully functional P451 allele. To determine the potential role of P2rx7 under metabolic and thermogenic stress conditions, we performed comparative studies using male P2rx7 knockout (KO) and respective wild-type controls on both BALB/c and C57BL/6 backgrounds. Our data show that adipose P2rx7 mRNA levels are increased in obese mice. Moreover, P2rx7 deficiency results in reduced levels of circulating CCL2 and IL6 with a moderate effect on gene expression of pro-inflammatory markers in white adipose tissue and liver of BALB/c and C57BL/6 mice. However, P2X7 expression does not alter body weight, insulin resistance, and hyperglycemia associated with high-fat diet feeding on both genetic backgrounds. Furthermore, deficiency of P2rx7 is dispensable for energy expenditure at thermoneutral and acute cold exposure conditions. In summary, these data show that—apart from a moderate effect on inflammatory cytokines—P2X7 plays only a minor role in inflammatory and thermogenic effects of white and brown adipose tissue even on the BALB/c background.
Why Aboutness Matters: Meta-Fictionalism as a Case Study
Authors: Plebani Matteo 
Published: October 2020

AbstractRecent work in the philosophy of language attempts to elucidate the elusive notion of aboutness (Berto 2018; Lewis 1988; Fine 2017a, b; Hawke 2017; Moltmann 2018; Yablo 2014). A natural question concerning such a project has to do with its motivation: why is the notion of aboutness important? Stephen Yablo (2014) offers an interesting answer: taking into consideration not only the conditions under which a sentence is true, but also what a sentence is about opens the door to a new style of criticism of certain philosophical analyses. We might criticize the analysis of a given notion not because it fails to assign the right truth conditions to a class of sentences, but because it characterizes those sentences as being about something they are not about. In this paper, I apply Yablo’s suggestion to a case study. I consider meta-fictionalism, the view that the content of a mathematical claim S is ‘according to standard mathematics, S’. I argue, following Woodward (2013), that, on certain assumptions, meta-fictionalism assigns the right truth-conditions to typical assertoric utterances of mathematical statements. However, I also argue that meta-fictionalism assigns the wrong aboutness conditions to typical assertoric utterances of mathematical statements.