bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Keterampilan Metakognitif Mahasiswa dalam Mengkaji Implementasi Kurikulum Kimia di SMA melalui Project Based Learning
Authors: Harta Johnsen 
Published: January 2020

Eksistensi kurikulum bukan hanya sekadar menegaskan pentingnya perhatian terhadap pendidikan, namun juga terkait usaha kita untuk menyelami dan memaknai peran vital kurikulum yang akan membawa pendidikan Indonesia dapat bersaing hingga level internasional. Khususnya dalam pembelajaran kimia, mengedepankan struktur dan implementasi kurikulum yang tepat menjadi bagian esensial untuk memperkenalkan dan menghidupkan peran kebermaknaan pembelajaran kimia. Penelitian ini bertujuan untuk menyelidiki metakognitif mahasiswa dalam mengkaji implementasi kurikulum SMA di Yogyakarta. Penelitian ini merupakan penelitian deskriptif kuantitatif-kualitatif dalam project based learning. Penelitian dilaksanakan selama bulan Agustus hingga Desember 2018. Instrumen penelitian yang digunakan berupa lembar wawancara, soal tes sesuai indikator level metakognitif, kuesioner berupa Metacognitive Awareness Inventory (MAI), lembar penilaian presentasi-diskusi, dan lembar refleksi. Teknik pengumpulan data meliputi analisis deskriptif hasil tes level metakognitif, analisis kuesioner MAI menggunakan Rasch Model, analisis lembar wawancara, observasi, dan refleksi secara deskriptif. Hasil penelitian menunjukkan bahwa mahasiswa sudah baik dalam hal menganalisis struktur kurikulum dan mengkaji implementasi kurikulum kimia SMA di Yogyakarta dengan perolehan rata-rata nilai 82,65 untuk pemahaman kurikulum dan bedah komponen dan konten kimia SMA dalam kurikulum memiliki rata-rata nilai 89,57. Terkait nilai akhir proyek kelompok, rata-rata nilai dari aspek kemampuan dan analisis dalam wawancara guru kimia adalah 87,11; rata-rata nilai untuk desain presentasi adalah 91,51; dan rata-rata nilai keterampilan presentasi dan diskusi adalah 83,14. Dalam tes metakognitif, 87,5% dan 97,14% mahasiswa dapat tuntas dan didukung pula dengan nilai alpha Cronbach sebesar 0,94 untuk hasil analisis kuesioner MAI menggunakan Rasch Model. Kelima level metakognitif sudah tercapai dengan baik.

Kata kunci
Project based Learning, Keterampilan Metakognitif, Implementasi Kurikulum, Kimia SMA
Resistance Variability of Arabica Coffee Genotypes (Coffea arabica L.) to Leaf Rust Disease (Hemileia vastatrix)
Authors: Malau Sabam 
Published: January 2020

<p>Coffee leaf rust disease (<em>Hemileia vastatrix</em>) causes large damage to Arabica coffee plantation in Asia, Africa, and America. In Indonesia, particularly in North Sumatra, the resistance level of Arabica coffee genotypes is still unknown. The objective of this research was to determine the resistance variability of Arabica coffee genotypes to leaf rust disease and its relation to leaf morphology. A total of 84 genotypes grown in North Sumatra were selected in November 2015 and 2016, and December 2017 using a nested design. Data were analyzed using nested design, correlation, stepwise regression, and cluster hierarchy analysis. The result showed that the G56 genotype performed the most resistant to leaf rust disease, with a severity of 5.21%. The severity of leaf rust disease has high genotypic variation, low heritability, and high genetic advance. Leaf morphological ratios showed moderate to high genotypic variation and heritability. The severity of leaf rust (y) significantly correlated with the ratio of leaf length to leaf area (x<sub>1</sub>) and the ratio of leaf length to leaf width (x<sub>2</sub>) with the equation y = 2.04 + 62.48x<sub>1 </sub>- 3.95x<sub>2,</sub> and multiple correlation coefficients R = 0.470 **. By using the leaf rust severity and the two ratios in the cluster analysis, these 84 genotypes were grouped into five clusters. The result showed that several Arabica coffee genotypes with a high level of resistance to leaf rust disease are potential to be further developed.</p>
Acceptable short-term outcomes after open heart surgery in kidney transplant recipients: a case control study
Authors: Witczak Bartlomiej Jozef , Svennevig Jan L. , Hartmann Anders , Fiane Arnt E. , Åsberg Anders 
Published: January 2020

AbstractBackground Cardiovascular disease is common in kidney transplant recipients. They are considered high risk surgery candidates due to comorbidity and immunosuppression. We assessed short-term results of open-heart surgery in kidney transplant recipients and matched controls between 1989 – 2016 at our center. Methods Ninety-five patients underwent open heart surgery (48 coronary artery bypass grafting, 27 valve replacements or repairs and 29 combined procedures) after kidney transplantation. Controls (n=95) were matched for age, sex, type and year of surgery. Mean follow-up was 5.6 (4.9) years. Independent two-sample t-test and chi-square test were used to compare continuous variables and frequencies, respectively. Logistic regression was used to identify preoperative risk factors for 30-day mortality. Results Included were 76 men and 19 women; mean age 60.3 (11.1) years, 7.1 (5.6) years after transplantation. Kidney transplants had lower renal function, more hypertension, but less pulmonary hypertension than matched controls. Intraoperative data was comparable between kidney transplants and controls. Kidney transplants experienced more frequent acute kidney injury (57% versus 21%, p<0.001), more bleeding (1288 (1081) mL versus 957 (548) mL, p=0.01) and more red cell transfusions (4.9 (5.6) versus 3.2 (5.4) units, p=0.04). Infections were borderline more frequent in kidney transplants (30% versus 20%, p=0.10). Thirty-day mortality was 6.3% in kidney transplants and 2.1% in controls (p=0.14). Independent risk factors for 30-day mortality were acute myocardial infarction last 90 days before surgery (OR 12.5, p=0.02) and current smoking (OR 17.3, p=0.02). Conclusions Kidney transplant recipients undergoing cardiac surgery have acceptable short-term results compared with matched controls; 30-day mortality rates were similar. Careful peri- and postoperative management is, however, warranted as kidney transplant recipients experience more bleeding and higher frequency of AKI.
Identification of CpG methylation and non-CpG methylation is associate with Lymphocyte specific helicase
Authors: Lai Weiwei , Ouyang Lianlian , Liu Na , Liu Shouping , Shi Ying , Chen Ling , Wang Xiang , Xiao Desheng , Liu Shuang , Tao Yongguang 
Published: January 2020

Abstract
Background : CpG methylation is crucial for normal cell development and differentiation in mammalian genomes, whereas non-CpG methylation presents in stem cells and appears to be enriched in pluripotent cell types. Lymphocyte-specific helicase (LSH) is critical for normal cell development as a regulator of CpG methylation, but whether there is potential link between LSH and non-CpG methylation remains unclear. Results: In this study, we using reduced representation bisulfite sequencing(RRBS), we found that LSH affected DNA methylation patterns in lung adenocarcinoma (LUAD) cells. We analyzed 12,239 differentially methylated regions (DMRs) for CpG methylation and 1605 DMRs for non-CpG methylation. LSH did not change CpG methylation at a global level, but partially change the methylation of CpG islands (CGIs). Interestingly, LSH reduced approximately 30% of CHH methylations at CGIs and consistently decreased CHG and CHH methylation patterns. However, LSH increased the CHH methylation level in satellite and simple-repeat region. The KEGG analysis showed LSH to be linked with a markedly enrichment in focal adhesion and the PI3K-Akt pathway. Further analysis indicated that LSH might epigenetically regulate the binding of transcription factors, including SP2, etc. Conclusions: These findings suggest that LSH have no remarkable influence on CpG methylation but it partially alter non-CpG methylation and repeat sequences in LUAD. LSH inhibits non-CpG methylation in cancer and may function as a regulator to promote tumorigenesis through inhibiting non-CpG methylation.
Addition of Taxanes to Platinum and Fluoropyrimidines in Adjuvant Setting Did Not Improve Survival in Patients with Gastric Cancer after Curative Gastrectomy
Authors: Wu Lili , Wu Zhijun , Xu Hui , Wu Changhao , Zhang Cheng , Feng Ying , Hao Jiqing , Ma Tai 
Published: January 2020

Abstract
BackgroundTo evaluate whether the addition of taxane to platinum and fluoropyrimidines in adjuvant chemotherapy would result in longer survival than platinum plus fluoropyrimidines in patients who underwent curative gastrectomy.MethodsThis study retrospectively analyzed survival for patients with stage Ⅱ-Ⅲ gastric adenocarcinoma who received curative gastrectomy and adjuvant chemotherapy with platinum plus fluoropyrimidines (PF group) or taxanes and platinum plus fluoropyrimidines (TPF group). Survival curves were estimated using the Kaplan-Meier method, and the differences were compared using the log-rank test.ResultsBaseline characteristics were balanced between the PF group and TPF group. The median disease-free survival (DFS) was 14.9 months (95% CI: 11.0-18.8) in the PF group and 13.8 months (95% CI: 9.3-18.3) in the TPF group (HR=0.90, 95% CI: 0.63-1.29, log-rank test, P=0.560). The median overall survival (OS) was 30.0 months for patients in the PF group (95% CI: 24.5-35.5) and 25.6 months (95% CI: 22.3-28.9) for those in the TPF group (HR=0.93, 95% CI: 0.64-1.35, log-rank test, P=0.705).ConclusionFor stage Ⅱ-Ⅲ gastric adenocarcinoma, the adjuvant triple combination of TPF regimen after curative gastrectomy did not demonstrate survival benefit compared to the PF regimen.
Thoracic Endometriosis presented as catamental hemoptysis: Fourteen Cases of a Rare Disease and the hormonal treatment management
Authors: Dai Yi , Li Meng-Hui , Liu Yong-Jian , Liu Bing , Wu Yu-Shi , Lang Jing-He , Zhang Zhen-Yu , Leng Jin-hua 
Published: January 2020

Abstract
Background: Thoracic endometriosis syndrome (TES) is a rare disease in which a functioning endometrial tissue is observed in the pleura, lung parenchyma, airways, or diaphragm. The optimal management of this disease remains a matter of debate Methods: Retrospective study in one university based tertiary care hospital between 1997 to 2017. 14 women presented as CH diagnosed with thoracic endometriosis were included. The main outcome of measure was cessation or recurrence of the clinical manifestations of thoracic endometriosis. Baseline parameters were presented using descriptive statistics. For categorical variables, Pearson’s chi-square tests or Fisher’s exact tests was used as appropriate to describe the characteristic of thoracic endometriosis presented as CH, and the long-term prognosis after hormonal treatment. Results : The mean onset age of the 14 patients was 30.21±5.40 years. Catamenial hemoptysis (CH) was characteristic symptom of these patients, and most of patients (13/14, 92.9%) had regular menstruation and only 42.9% (6/14) of the patients complained of different degrees of dysmenorrhea. All patients underwent chest computed tomography (CT) scan during menstruation and 2 or 3 weeks after menstruation, which showed the obvious shrinking or disappearance of the lesions. No active bleeding on bronchial mucosa were observed in patients with CH, and the bronchoalveolar lavage (BAL) did not find the typical abnormality. All of patients were given GnRH-a for 3 to 6 months, eleven of them were administered with COCs cyclically after GnRH-a. All patients were followed up and the median follow-up duration was 24 months. Hemoptysis recurrence was observed in one patient. Conclusion: CH is a rare clinical entity of thoracic endometriosis, which has the typical cyclic manifestation with menstruation. The change of CT images during and after menstruation or the response to GnRHa were helpful for accurate diagnosis. Hormonal treatment with GnRH-a followed by COCs cyclically could be employed as a choice of therapy for efficient management of thoracic endometriosis.
Fidelity to individual components of a standardized labor induction protocol and association with improved obstetric outcomes: secondary analysis of a randomized controlled trial
Authors: Hamm Rebecca Feldman , Beidas Rinad S , Srin Sindhu K. , Levine Lisa D. 
Published: January 2020

Abstract
Background Standardized labor induction protocols improve obstetric outcomes. However, these protocols are complex. The Consolidated Framework for Implementation Research describes intervention components as “core” and “adaptable periphery.” We aimed to identify core components by investigating the individual components of an evidence-based protocol most associated with effectiveness. We planned to utilize this information to simplify our protocol prior to multi-site implementation. Methods This is a secondary analysis of an RCT comparing time to delivery among four labor induction methods. All patients enrolled in the trial had their labor managed with a multidisciplinary-developed, evidence-based labor induction protocol. For each patient’s induction, we assessed fidelity to 7 components of the protocol. Primary effectiveness outcomes included cesarean delivery, maternal morbidity, and neonatal morbidity. Bivariate analyses assessed association of each component with each primary effectiveness outcome. Multivariable logistic regression determined independent predictors of each outcome while controlling for demographic and clinical factors known to be related to our outcomes. Results The 491 patients enrolled in the RCT were included in this analysis. While multiple components were associated with each outcome in bivariate analysis, few were found to be independent predictors of effectiveness in multivariable analysis. For cesarean delivery, only one component “for women in active labor, all cervical exams were performed ≤2.5 hours apart” was an independent predictor. For maternal morbidity, only one “if an intracervical Foley catheter was utilized for cervical ripening, it was removed within 12 hours of placement” remained significant. For neonatal morbidity, two components “all cervical exams performed in latent labor were performed ≤4.5 hours apart” and “for women in active labor, all cervical exams were performed ≤2.5 hours apart” remained independent predictors. Of the independent predictors of effectiveness, most reflected the overarching concept of “frequent exams in labor will allow for more frequent intervention when no change is made”.Conclusions This study demonstrates a novel strategy to identify which components of an evidence-based intervention should be “core” and which are “adaptable periphery”; this provides valuable information when designing for dissemination and implementation. With an understanding of the relationship between fidelity to individual protocol components and effectiveness, we can systematically simplify interventions prior to large-scale implementation, a potential strategy to increase implementation success. These data will be used to streamline our protocol to best target cesarean rate and maternal/neonatal morbidity prior to a planned type I hybrid effectiveness-implementation trial.
Impact of shift work on the cortisol awakening response and stress: a longitudinal study in female shifting monthly nurses
Authors: Chang Wen-Pei , Jen Hsiu-Ju 
Published: January 2020

Abstract
Background: Although the majority of shift nurses are female, there is still an expectation that they fulfil the traditional role of women in the family, often conflicting with shift work, increases stress, and affects cortisol secretion patterns. This study was to understand the changes in the cortisol awakening response (CAR) and work stress in nursing personnel working in different shifts. Methods: 41 female shift nurses were recruited that fit criteria using purposive sampling. We obtained personal information, administered the Taiwan Nurse Stress Checklist (NSC), and the nurses themselves collected saliva samples upon waking and 30 minutes after waking for three consecutive days at home. We then analyzed the data obtained using a hierarchical linear model. Results: The results revealed that night-shift nurses derived significantly more stress from an inability to complete personal tasks than did day-shift nurses ( B = 4.39, p < .001) or evening-shift nurses ( B = 3.95, p < .001). Night-shift nurses also exhibited significantly lower CARi than did day-shift nurses ( B = -3.41, p < .001) or evening-shift nurses ( B = -2.92, p < .01) as well as significantly lower cortisol levels 30 minutes after waking than did day-shift nurses ( B = -3.88, p < .001) or evening-shift nurses ( B = -3.31, p < .01). Conclusions: This study indicate that female night-shift nurses displayed the lowest CARi and cortisol levels 30 minutes after waking and are more negatively affected by being unable to complete personal tasks.
The relationship between spiritual health and happiness among the students of health Sciences in Guilan University of Medical Sciences
Authors: Kasmaei Parisa , Fattahi Esmaeil , Hassankiadeh Roghaye Farhadi , Almasi Afshin , Ziapour Arash , Kasraei Farzaneh , Rastegar Ayoob , Roodpishi Zahra Ensandoost , Nasirizadeh Mohtaram , Ghasemabadi Mahsa Rostamtabar 
Published: January 2020

Abstract
Background: Spirituality and spiritual health are important concepts among human societies, and the relation of these concepts to other scientific ones is important for health professionals. The purpose of this study is to investigate the relationship between spiritual well-being and happiness among the students of health sciences of Guilan University of Medical Sciences. Methods: This is a cross-sectional and descriptive-analytic study carried out among 322 students through census sampling method. The Spiritual Health Questionnaire (SWBS) was made by Pulotsin and Ellison in 1982 and used to measure spiritual well-being. Oxford Happiness Questionnaire (OHI) was used to measure happiness designed in 2007 by Argyle. Validity and reliability of two questionnaires are higher than 0.90. Cronbach's alpha in each dimension of spiritual well-being and also happiness in the present study was higher than 0.7. Results : The mean and standard deviation of spiritual health were 55.82±4.71 and the mean and standard deviation of students' happiness was 60.88+-12.9. There is no statistical correlation between spiritual health with any of the demographic variables. It means that the average spiritual health is not significantly different at different ages or between single students and married students. Conclusion: The results showed that there is a positive and significant relationship between spiritual well-being and happiness. Also, there is a meaningful relationship between all aspects of spiritual health with happiness. The findings of this research illustrate the happiness is reduced by increasing the average age.
Reversible Long Term Contraceptives Utilization among Married Women of Reproductive Age Group in Areka town, South Ethiopia
Authors: Dake Samson Kastro , Lera Temesgen 
Published: January 2020

Abstract
Background: In low income countries, maternal mortality rate remains high. Bearing many children is the main factor affecting maternal health. This study aimed to estimate the prevalence of reversible long term contraceptives utilization and identify factors associated with it among married women of child bearing age in Areka town in South Ethiopia Methods: We did a community-based cross-sectional survey involving systematically recruited 346 married women of reproductive age group. Data was collected using a structured interviewer-administered questionnaire on May 2019. We used SPSS version 25 for data entry and analyses. Bivariate logistic regression analysis was used to select exposure variables with a crude association. Multivariate analysis was done to control for potential confounders and identify predictors of the outcome. Adjusted Odds Ratio (AOR) with 95% Confidence Interval (CI) was reported and statistical significance was declared at p <0.05.Results: The prevalence of reversible long term contraceptives utilization among married women of reproductive age group was 38.7% in the study area. Utilization of reversible long term contraceptives was positively associated with being Protestant Christian religion follower (AOR=5.33; 95% CI: 1.63, 17.40), advanced educational status (AOR=5.78; 95% CI: 1.97, 17.02), history of abortion (AOR=7.17; 95% CI: 2.81, 18.27), and having a better attitude towards reversible long term contraceptives (AOR=2.85; 95% CI: 1.46, 5.57). Whereas, being a housewife (AOR=.27; 95% CI: .09, .79) and daily laborer (AOR=.14; 95% CI: .02, .80), having no radio in the household (AOR=.40; 95% CI: .16, .99) and making fertility decisions alone (AOR=.12; 95% CI: .04, .37) were negatively associated. Conclusion: Women should be empowered educationally through other alternative opportunities to school. On top of electronic media, other alternative media should be used to convey messages on contraceptives particularly RLTCs. Behavioral change communications would benefit women in shaping their attitudes towards RLTCs.
Healthcare Providers’ Knowledge and Their Perceived Factors Influencing Cancer Palliative Care Services in Kwazulu-natal
Authors: Dlamini Minenhle , Hlongwana Khumbulani W. , Ginindza Themba G. 
Published: January 2020

Abstract
Background: Healthcare providers spend most of their time in direct care of critically ill patients. The family members of the critically ill patients are not spared from managing physical, psychological, emotional and spiritual symptoms, yet many of them feel anxious and unprepared to care for palliative patients. The purpose of this study was to determine healthcare providers’ knowledge and perceived factors influencing cancer palliative care (PC) services in the selected sites of Durban and Pietermaritzburg, KZN. Methods: This was a mixed methods study using a structured questionnaire and focus group discussions (FGDs) for quantitative and qualitative aspects, respectively. All healthcare providers were selected through convenience sampling, based on being relevant to the study objectives. Twenty-seven healthcare providers participated in structured questionnaires with eight being further selected to participate in an FGD based on being information-rich. IBM SPSS Statistics (v.25) and NVIVO 12 Pro software were used to analyze quantitative and qualitative data, respectively. Results: The mean (+SD) age of the 27 participants was 42.52 (+11.37) years and about 48.1% were within the age-group 31–40 years. The majority of participants were females (77.7%) and were married (59.5%). More than four-fifths (81.5%) had attended up to tertiary level as the highest level of education, 85.1% were permanently employed and 96.3% were from urban areas. The majority of participants had been trained in PC (70.4%), 55.5% had less than five years’ experience working as palliative healthcare providers and 51.8% rated their experience of caring for cancer patients as good. Perceived barriers in patients seeking PC, included three themes, namely: (1) effects of intra-departmental collaboration, (2) caregivers’ perspectives regarding the complexities of PC seeking barriers and (3) innate factors that sustain the community caregivers’ motivation. Conclusion: Healthcare providers trained and/or implementing PC have varying levels of competencies, suggesting a need for continuous professional development (CPD) to build PC skills. The results also provided clear evidence that collaboration among the stakeholders within the Department of Health can potentially enhance PC service delivery in KwaZulu-Natal.