bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Complications of Anterior Cervical Fusion Using Zero-profile Implants: Analysis of 193 Consecutive Cases
Authors: Dantas Fernando Luiz Rolemberg , Sandes Bruno Lacerda , Dantas François , Caires Antônio Carlos Vieira , Cariri Gustavo Agra , Filho Gilberto de Almeida Fonseca , Botelho Ricardo Vieira 
Published: January 2020

Abstract
Background: Anterior access to the cervical spine is considered safe, with the most common complication being dysphagia. The objective of this study is to describe early complications of anterior cervical fusion using Zero-profile implants in a neurosurgery department and compare these with the literature.
Methods: In a retrospective study, we analyzed data of patients diagnosed with cervical spondylodiscoarthrosis at a single center between January 2011 and January 2017 who underwent anterior cervical fusion using Zero-profile implants. The analyzed demographic data included age, sex, symptoms, number of operated levels, time of preoperative symptoms, type of symptom and length of hospital stay. Immediate postoperative complications were noted.
Results: A total of 193 consecutively operated patients were included. Of the total, 106 patients were female (54.9%). The average age of the patients was 52.7 years. Average hospitalization was 3.20 days and the average number of levels was 1.68.
Complications were noted in 57 patients (29.5%). Older patients had more complications (mean 55.5 years versus 51.5). The average length of stay was longer for patients with complications. The average number of operated levels was 1.84 in patients with complications and 1.61 in those who did not complicate. The most common complications were dysphagia (9.32%) and dysphonia (5.69%). We had 1 case of C5 monoparesis and 1 case of epidural hematoma, considered serious complications.
Conclusions: Postoperative dysphagia and dysphonia were the most common complications in our series. Risk factors for complications were advanced age and number of operated levels.
Pregnancy risk factors and outcomes in the transition from respiratory distress syndrome (RDS) to RDS and acute respiratory distress syndrome (ARDS) in preterm infants: a retrospective cohort study
Authors: Chen Long , Xiong Jing , Guo Jingyu , Li Jie , Shi Yuan , Bao Lei 
Published: January 2020

Abstract
Background: Neonatal acute respiratory distress syndrome (ARDS) has been proposed in 2017. Growing evidence suggests that pregnancy risk factors (PRF) contribute to the deterioration of respiratory distress. The present study aims to clarify PRF and outcomes in the transition from respiratory distress syndrome (RDS) to RDS and ARDS in preterm infants. Methods : A retrospective study was conducted at a tertiary neonatal intensive care unit from Jan-1, 2017 to July-30, 2018. Preterm neonates diagnosed with RDS were enrolled at baseline and followed up during hospitalization. The primary outcomes were to identify the relationships between PRF and transition from RDS to RDS and ARDS and the incidences of bronchopulmonary dysplasia (BPD). Results: A total of 269 preterm infants were included. Of them, 168 were diagnosed with both RDS and ARDS, and 101 with RDS. Comparing with preterm neonates with both RDS and ARDS, that with RDS was related to the decreased incidence of BPD (22:79 vs 61:107, 95%CI:0.27-0.85, P =0.010), especially in the subgroup of severe BPD (3:98 vs 17:151, 95%CI:0.08-0.95, P =0.032) and two or more of surfactant (14:87 vs 43:125, 95%CI:0.24-0.91, P =0.023). PRF including intrahepatic cholestasis during pregnancy (ICP), pernicious placenta previa (PPP), hypertensive disorder complicating pregnancy (HDCP) and gestational diabetes mellitus (GDM) were not shown differences between the two groups. Conclusion : Preterm infants with both RDS and ARDS were easier to convert to BPD as compared with that with RDS. Trial registration: Chinese Clinical Trial Registry, ChiCTR1900026980 Keywords: ARDS · RDS · risk factors · outcomes · neonate
Low-Value Clinical Practices In Adult Traumatic Brain Injury: An Umbrella Review
Authors: Moore Lynne , Tardif Pier-Alexandre , Lauzier François , Bérubé Mélanie , Archambault Patrick , Lamontagne François , Chassé Michael , Stelfox Henry T , Gabbe Belinda , Lecky Fiona , Kortbeek John , Lessard-Bonaventure Paule , Truchon Catherine , Turgeon Alexis 
Published: January 2020

Abstract
Background Despite numerous interventions and treatment options, the outcomes of traumatic brain injury (TBI) have improved little over the last three decades, which raises concern about the value of care in this patient population. We aimed to synthesize the evidence on 14 potentially low-value clinical practices in TBI care. Methods Using umbrella review methodology, we identified systematic reviews evaluating the effectiveness of 14 potentially low-value practices in adults with acute TBI. We present data on methodological quality (AMSTAR-2), reported effect sizes and credibility of evidence (I to IV). Results The only clinical practice with evidence of benefit was therapeutic hypothermia (credibility of evidence II to IV). However, the most recent meta-analysis on hypothermia based on high-quality trials suggested harm (credibility of evidence IV). Meta-analyses on platelet transfusion for patients on antiplatelet therapy were all consistent with harm but were statistically non-significant. For the following practices, effect estimates were consistently close to the null: CT in adults with mild TBI who are low-risk on a validated clinical decision rule; repeat CT in adults with mild TBI on anticoagulant therapy with no clinical deterioration; antibiotic prophylaxis for external ventricular drain placement; and decompressive craniectomy for refractory intracranial hypertension. Conclusions We identified five clinical practices with evidence of lack of benefit or harm. However, evidence could not be considered to be strong for any clinical practice as effect measures were imprecise and heterogeneous, systematic reviews were often of low quality and most included studies had a high risk of bias. Protocol registration PROSPERO: CRD42019132428
Associations among Cognitive Functions, Plasma DNA, and Diffusion tensor image along the perivascular space (DTI-ALPS) in Patients with Parkinson's Disease
Authors: Chen Hsiu-Ling , Chen Pei-Chin , Lu Cheng-Hsien , Tsai Nai-Wen , Yu Chiun-Chieh , Chou Kun-Hsien , Yun-Ru Lai , Taoka Toshiaki , Lin Wei-Che 
Published: January 2020

Abstract
Background Parkinson’s disease (PD) is a common neurodegenerative disease associated with accumulation of misfolding proteins and increased neuroinflammation. The purpose of this study was to utilize diffusion tensor image analysis along the perivascular space (DTI-ALPS) to evaluate glymphatic system activity, and its relationship with systemic oxidative stress status in PD patients. Methods Magnetic resonance imaging and neuropsychological tests were conducted on 25 PD patients with normal cognition (PDN), 25 PD patients with mild cognitive impairment (PD-MCI), 38 PD patients with dementia (PDD), and 47 normal controls (NC). Oxidative stress status was assessed by plasma DNA level. Differences in ALPS-index among the subgroups were assessed and further correlated with cognitive functions and plasma DNA levels. Results The PD-MCI and PDD groups showed significantly lower ALPS-index compared to normal controls. The lower ALPS-index was correlated with higher plasma nuclear DNA, mitochondrial DNA levels, and lower cognitive scores. Conclusions Lower diffusivity along the perivascular space, represented by lower ALPS-index, indicates impairment of the glymphatic system in PD patients. The correlation between elevated plasma nuclear DNA levels and lower ALPS-index support the notion that PD patients may exhibit increased oxidative stress associated with glymphatic system microstructural alterations.
A Comparison of Cylindrical and Tapered Stem Designs in Femoral Revision Hip Arthroplasty
Authors: Zhang Yu , Zhang Ye , Sun Jian-Ning , Hua Zi-Jian , Chen Xiang-Yang , Feng Shuo 
Published: January 2020

Abstract
Background Both cylindrical and tapered stems are commonly used in revision total hip arthroplasty, it is unclear whether the geometry of prosthesis stem has an effect on the patient's efficacy and prognosis. we assume the tapered stem is superior to the cylindrical stem for better clinical outcome. Methods A multicenter review of 120 femoral revisions with Paprosky I, II and III defects using cylindrical stem (54 hips) or tapered stem (66 hips) was performed with an average follow-up of 6 years. Demographic data was comparable between groups. Results There were no significant group differences were found in surgery time, bleeding volume and the postoperative Harris score, the level of overall satisfaction, 8-year cumulative survival. However, intraoperative fractures in the tapered group (4.5%) occurred significantly less than in the cylindrical group (14.8%), and stem subsidence was significantly less in the tapered group (2.17mm) than in the cylindrical group (4.17 mm). There was a higher ratio of bone repair and lower bone loss in the tapered group compared to the cylindrical group. The postoperative thigh pain rate was higher in the cylindrical group (12.9%) than in the tapered group (4.5%). Conclusion Both cylindrical stem and tapered stem can achieve satisfactory mid-term clinical results in revision THA; The tapered stem has better bone restoration of proximal femur, low incidence of intraoperative fracture, and low postoperative thigh pain rate compared with the cylindrical stem.
Plastic lengthening amputation with vascularized bone grafts in children with bone sarcoma: A preliminary report
Authors: Zhao Zhiqiang , Jin Qinglin , Xie Xianbiao , Wang Yongqian , Lin Tiao , Yin Junqiang , Huang Gang , Zou Changye , Shen Jingnan 
Published: January 2020

Abstract
Background At present, amputation was widely adopted for young patients when limb salvage is deemed risky with several surgical strategy such as rotationplasty. However, leg length discrepancies and unfavorable cosmetic results is an indispensable complication of this strategy. The purpose of this study is to demonstrate a novel reconstruction strategy and evaluate the early clinical and functional outcomes of the strategy. Methods Plastic lengthening amputation has been developed by lengthening the stump to preserve one additional distal joint for fixing the artificial limb well. The surgical technique and postoperative management were documented, and the functional outcomes were compared with those of traditional amputation. Six pairs of patients matched for age, sex, location, pathologic type and final prosthesis underwent individually designed plastic lengthening amputation with vascularized autografts or traditional amputation between January 2005 and December 2007. All patients were followed, and the locomotor index and MSTS were used to describe and quantitatively grade limb functional outcomes after amputation. The complications and functional outcomes of the two procedures were compared. Results Twelve patients with osteosarcoma or Ewing sarcoma in either the femur or tibia were included in the study. Six patients underwent plastic lengthening amputations, three of whom also underwent vascular anastomosis. All patients were followed for an average of 48.17 months; bone healing required an average of 3.3 months. No local recurrence was found. The average postoperative locomotor index functional score of the affected limb was 32.67 ± 5.89 in the plastic lengthening amputation group but was 19.50 ± 7.87 in the traditional amputation group. Conclusions Plastic lengthening amputations with vascularized autografts could preserve one additional distal joint and improve the function of the amputated limb in selected bone sarcoma patients. MSTS analysis also indicated that the patients would have better functional outcomes with plastic lengthening amputation than with traditional amputation.
Economic impact of therapies on perioperative hemodynamic optimization in surgical patients from the perspective of developing country: Economic study and Meta-analysis
Authors: Silva João M , Menezes Pedro Ferro L , Carvalho Flavia Helena S , Oliveira Mariana Augusta N , Filho Francisco Nilson F Cardoso , Fernando Bruna N , Carmona Maria Jose C , Teich Vanessa D , Lobo Suzana M , Malbouisson Luiz Marcelo S 
Published: January 2020

Abstract
Background: Health resources are limited and need to be rationally distributed. Studies suggest that hemodynamic optimization therapy can reduce length of hospital stay, complications and costs. However, Brazilian data are scarce. Therefore, the objective of this analysis was to evaluate whether the improvement demonstrated by hemodynamic optimization therapy in surgical patients could result in lower costs from the perspective of the Brazilian public unified health s ystem (SUS). Method: A meta-analysis was performed comparing surgical patients who underwent hemodynamic optimization therapy (intervention) with patients submitted to standard therapy (control) in terms of complications and hospital costs. The cost-effectiveness analysis evaluated the clinical and financial benefits of hemodynamic optimization protocols for surgical patients. The analysis considered the clinical outcomes of randomized studies published in the last 20 years that involved surgeries and hemodynamic optimization therapy. Indirect costs were not included in the analysis. Results: A total of 21 clinical trials with a total of 4872 surgical patients were selected. Comparison of the intervention and control groups showed lower rates of infectious (RR=0.66; 95% CI=0.58-0.74), renal (RR=0.68; 95% CI=0.54-0.87), and cardiovascular complications (RR=0.87; 95% CI=0.76-0.99) and a tendency toward lower rates of respiratory complications (RR=0.82; 95% CI=0.67-1.02). There was no difference in mortality (RR=1.02; 95% CI=0.80-1.3) between groups. In the analysis of total costs, the intervention group showed a cost reduction of R$396,024.83 for every 1000 patients treated compared to the control group. The patients in the intervention group showed greater effectiveness, with 1.0 fewer day in the ICU and hospital. In addition, there were 333 fewer patients with complications, with a consequent reduction of R$1,630,341.47 for every 1000 patients treated. Conclusions: Hemodynamic optimization therapy is cost-effective and would increase efficiency and decrease the burden of the Brazilian public health system.
Genomic Analysis Of Spanish Wheat Landraces Reveals Their Variability And Potential For Breeding
Authors: Pascual Laura , Ruiz Magdalena , López-Fernández Matilde , Pérez-Peña Helena , Benavente Elena , Vázquez José Francisco , Sansaloni Carolina , Giraldo Patricia 
Published: January 2020

Abstract
Background One of the main goals of the plant breeding in the 21 st century is the development of crop cultivars that can maintain current yields in unfavorable environments. Landraces that have been grown under varying local conditions include genetic diversity that will be essential to achieve this objective. The Center of Plant Genetic Resources of the Spanish Institute for Agriculture Research maintains a broad collection of wheat landraces. These accessions, which are locally adapted to diverse eco-climatic conditions, represent highly valuable materials for breeding. However, their efficient use requires an exhaustive genetic characterization. The overall aim of this study was to assess the diversity and population structure of a selected set of 380 Spanish landraces and 52 reference varieties of bread and durum wheat by high-throughput genotyping. Results The DArTseq GBS approach generated 10K SNPs and 40K high-quality DArT markers, which were located against the currently available bread and durum wheat reference genomes. The markers with known locations were distributed across all chromosomes with relatively well-balanced genome-wide coverage. The genetic analysis showed that the Spanish wheat landraces were clustered in different groups, thus representing genetic pools providing a range of allelic variation. The subspecies had a major impact on the population structure of the durum wheat landraces, with three distinct clusters that corresponded to subsps. durum , turgidum and dicoccon being identified. The population structure of bread wheat landraces was mainly biased by geographic origin. Conclusions The results showed broader genetic diversity in the landraces compared to a reference set that included commercial varieties and higher divergence between the landraces and the reference set in durum wheat than in bread wheat. The analyses revealed genomic regions whose patterns of variation were markedly different in the landraces and reference varieties, indicating loci that have been under selection during crop improvement, which could help to target breeding efforts. The results obtained from this work will provide a basis for future genome-wide association studies.
Genome-wide identification of MAPKKK genes and their responses to phytoplasma infection in Chinese jujube (Ziziphus jujuba Mill.)
Authors: Liu ZhiGuo , Wang Lixin , Xue Chaoling , Chu Yuetong , Gao Weilin , Zhao Yitong , Zhao Jin , Liu Mengjun 
Published: January 2020

Abstract
Background: Mitogen-activated protein kinase (MAPK) cascades play vital roles in signal transduction in response to a wide range of biotic and abiotic stresses. In a previous study, we identified ten ZjMAPKs and five ZjMAPKKs in the Chinese jujube genome. We found that some members of ZjMAPKs and ZjMAPKKs may play key roles in the plant’s response to phytoplasma infection. However, how these ZjMAPKKs are modulated by ZjMAPKKKs during the response process has not been elucidated. Little information is available regarding MAPKKKs in Chinese jujube.Results: A total of 56 ZjMAPKKKs were identified in the jujube genome. All of these kinases contain the key S-TKc (serine/threonine protein kinase) domain, which is distributed among all 12 chromosomes. Phylogenetic analyses show that these ZjMAPKKKs can be classified into two subfamilies. Specifically, 41 ZjMAPKKKs belong to the Raf subfamily, and 15 belong to the MEKK subfamily. In addition, the ZjMAPKKKs in each subfamily share the same conserved motifs and gene structures. Only one pair of ZjMAPKKKs (15/16, on chromosome 5) was found to be tandemly duplicated. Using qPCR, the expression profiles of these MAPKKKs were investigated in response to infection with phytoplasma. In the three main infected tissues (witches’ broom leaves, phyllody leaves, and apparently normal leaves), ZjMAPKKK26 and -45 were significantly upregulated, and ZjMAPKKK3, -43 and -50 were significantly downregulated. ZjMAPKKK4, -10, -25 and -44 were significantly and highly induced in sterile cultivated tissues infected by phytoplasma, while ZjMAPKKK6, -7, -17, -18, -30, -34, -35, -37, -40, -41, -43, -46, -52 and -53 were significantly downregulated.Conclusions: For the first time, we present an identification and classification analysis of ZjMAPKKKs. Some ZjMAPKKK genes may play key roles in the response to phytoplasma infection. This study provides an initial understanding of the mechanisms through which ZjMAPKKKs are involved in the response of Chinese jujube to phytoplasma infection.
A multi-method characterization of natural terrestrial birnessites
Authors: Ling Florence T. , Post Jeffrey E. , Heaney Peter J. , Santelli Cara M. , Ilton Eugene S. , Burgos William D. , Rose Arthur W. 
Published: January 2020

Abstract
With a focus on a large set of natural birnessites collected from terrestrial, freshwater systems, we applied and compared the capabilities of X-ray diffraction (XRD), extended X-ray absorption fine structure (EXAFS), Fourier-transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS) to characterize crystal structure and chemistry. Using XRD, we successfully identified 3 of the 11 natural birnessite samples as hexagonal ranciéite-like phases, but the remaining samples yielded less interpretable “3-line” diffraction patterns with broad, asymmetrical peaks at d-spacings of ~7.2, ~2.4, and ~1.4 Å. EXAFS analysis suggested that many of these samples had characteristics of both triclinic and hexagonal birnessite. However, application of EXAFS to the ranciéite-like phases yielded unreasonably high concentrations of triclinic birnessite as an intergrowth, calling into question the use of synthetic hexagonal H-birnessite as an appropriate standard in the linear combination fitting of EXAFS data for natural birnessites. FTIR spectroscopy of the “3-line” birnessite samples successfully distinguished triclinic and hexagonal constituents, and analyses of peak positions suggested that natural birnessites occur as a full spectrum of triclinic and hexagonal intergrowths. XPS analysis of these samples revealed that higher Mn3+ concentrations relative to Mn2+ and Mn4+ are correlated to increased proportions of triclinic birnessite.
Big Data Analytics of EHRs: pathogenic relations of cancer with Ischaemic Heart Disease and Diabetes Mellitus
Authors: Kolesnichenko O. Yu. , Kolesnichenko Yu. Yu. , Pulit V. V. , Martynov A. V. , Sotnik A. Yu. , Khaykina I. A. , Marochkina E. B. , Minushkina L. O. , Pimenova K. V. , Bugakova A. S. , Vasilyeva E. Yu. , Komarov R. N. , Golovanov A. V. 
Published: January 2020

The incidences of cancer in patients with ischaemic heart disease and diabetes mellitus (types 1 and 2) were analyzed according to the electronic health records (medical information system qMS). For several years, a predominance of prostate cancer and colorectal cancer in almost 10 thousand patients with ischaemic heart disease were revealed; in patients with diabetes mellitus type 1 lung cancer was prevailed; and in patients with diabetes mellitus type 2 colorectal cancer and lung cancer were prevailed. Prostate cancer and ischaemic heart disease are associated with a general imbalance within estrogen receptors ERα, ERβ, gpER, which occurs in old age with reproductive function fading. Hyperglycemia in diabetes mellitus causes a blocking of the parathyroid hormone-related protein signaling pathway, which creates a favorable environment for carcinogenesis in the lungs. Hyperinsulinemia, as a result of insulin resistance in diabetes mellitus and in metabolic syndrome accompanying ischaemic heart disease, triggers signaling pathways, including mTOR, which contribute to the carcinogenesis in the large intestine epithelium. Three different patient samples showed the different pictures of tumor localization, and for each of the identified predominant cancer localization common signaling pathways with a concomitant metabolic disease can be distinguished.