bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-related quality of life for children and adolescents in school age with hypoplastic left heart syndrome: a single-centre study
Authors: Oberhuber Raphael D. , Huemer Sonja , Mair Rudolf , Sames-Dolzer Eva , Kreuzer Michaela , Tulzer Gerald 
Published: March 2020

AbstractData from neurological and radiological research show an abnormal neurological development in patients treated for hypoplastic left heart syndrome. Thus, the aim of this study was to survey the quality of life scores in comparison with healthy children and children with other heart diseases (mild, moderate, and severe heart defects, heart defects in total). Children with hypoplastic left heart syndrome (aged 6.3–16.9 years) under compulsory education requirements, who were treated at the Children’s Heart Center Linz between 1997 and 2009 (n = 74), were surveyed. Totally, 41 children and 44 parents were examined prospectively by psychologists according to Pediatric Quality of Life Inventory, a health-related quality of life measurement. The results of the self-assessments of health-related quality of life on a scale of 1–100 showed a wide range, from a minimum of 5.00 (social functioning) to a maximum of 100 (physical health-related summary scores, emotional functioning, school functioning), with a total score of 98.44. The parents’ assessments (proxy) were quite similar, showing a range from 10 (social functioning) up to 100. Adolescent hypoplastic left heart syndrome patients rated themselves on the same level as healthy youths and youths with different heart diseases. The results show that patients with hypoplastic left heart syndrome aged 6–16 years can be successfully supported and assisted in their psychosocial development even if they show low varying physical and psychosocial parameters. The finding that adolescent hypoplastic left heart syndrome patients estimated themselves similar to healthy individuals suggests that they learnt to cope with a severe heart defect.
Photochemical Production and Biological Consumption of CO in the SML of Temperate Coastal Waters and Their Implications for Air‐Sea CO Exchange
Authors: Sugai Youta , Tsuchiya Kenji , Shimode Shinji , Toda Tatsuki 
Published: March 2020

AbstractThe sea surface microlayer (SML), less than 1,000‐μm uppermost layer of the ocean water column, is located at the air‐sea interface and plays critical roles in global biogeochemical cycles and climate change through air‐sea gas exchange. To clarify the significance of the dynamics of carbon monoxide (CO) in the SML, where active photochemical and biological processes are expected, in air‐sea CO exchange, the production and consumption of CO in the SML and its sea‐air emission were investigated in temperate coastal waters. In the SML, the light‐normalized photochemical CO production rate was relatively high from spring to autumn (median: 2.57 nM [kWh m−2]−1) when relatively high absorbance of chromophoric dissolved organic matter (0.55 m−1) was observed. Biological CO consumption rate constant in the SML showed relatively high values from spring to autumn (mean ± standard deviation: 0.060 ± 0.010 h−1) during the period of relatively high water temperature (22.3 ± 2.7 °C). The calculated sea‐air CO flux (F) varied similarly to CO concentration in the subsurface water. Comparison among the production, consumption, and sea‐air emission of CO in the SML suggests that biological consumption in the SML can be ignored in air‐sea CO exchange throughout the year whereas photochemical production in the SML enhances F during summer under intense light, active biological production, and weak wind conditions. Further, seawater warming experiments found the tendency of the stimulation of biological CO consumption by water temperature increase from spring to autumn, which suggests negative but insignificant feedback on global warming.
Foraminiferal Patterns in Deglacial Sediment in the Western Ross Sea, Antarctica: Life Near Grounding Lines
Authors: Majewski Wojciech , Prothro Lindsay O. , Simkins Lauren M. , Demianiuk Ewa J. , Anderson John B. 
Published: March 2020

AbstractImproved multibeam swath bathymetry allows targeted coring of glacial landforms aiming at improving our understanding of sedimentary facies that developed in glacimarine settings during the post‐Last Glacial Maximum (LGM) deglaciation. Coupled with radiocarbon dates, we explore foraminiferal records from 18 sediment cores from the western Ross Sea largely from sites near paleo–grounding lines. We investigate post‐LGM foraminiferal assemblages from glacimarine environments, including those proximal and more distal to paleo–grounding lines, including environments influenced by subglacial meltwater outflow and further removed from direct glacial influence and subject to different oceanographic conditions. Agglutinated benthic foraminiferal assemblages dominate open marine facies deposited under the presence of High Salinity Shelf Water and significant primary production, while calcareous foraminiferal assemblages characterize grounding line‐proximal settings, some of which were potentially influenced by Modified Circumpolar Deep Water. Rapid deposition of meltwater plume deposits inhibited and, in some cases, significantly altered foraminifera abundance and diversity. Broadly in the Ross Sea, it appears that the high bathymetric gradient of grounding zone wedges is a key factor promoting rich benthic foraminiferal communities in habitats proximal to grounding lines. Therefore, we demonstrate that paleo–grounding line settings may archive high quality in situ foraminiferal data, which is imperative for paleoenvironmental and geochemical studies on glaciated continental margins worldwide.
Water Table Depth and Bedrock Permeability Control Magnitude and Timing of Transpiration‐Induced Diel Fluctuations in Groundwater
Authors: Harmon Ryan , Barnard Holly R. , Singha Kamini 
Published: March 2020

AbstractThe subsurface processes that mediate the connection between evapotranspiration and groundwater within forested hillslopes are poorly defined. Here, we investigate the origin of diel signals in unsaturated soil water, groundwater, and stream stage on three forested hillslopes in the H.J. Andrews Experimental Forest in western Oregon, USA, during the summer of 2017, and assess how the diurnal signal in evapotranspiration (ET) is transferred through the hillslope and into these stores. There was no evidence of diel fluctuations in upslope groundwater wells, suggesting that tree water uptake in upslope areas does not directly contribute to the diel signal observed in near‐stream groundwater and streamflow. The water table in upslope areas resided within largely consolidated bedrock, which was overlain by highly fractured unsaturated bedrock. These subsurface characteristics inhibited formation of diel signals in groundwater and impeded the transfer of diel signals in soil moisture to groundwater because (1) the bedrock where the water table resides limited root penetration and (2) the low unsaturated hydraulic conductivity of the highly fractured rock weakened the hydraulic connection between groundwater and soil/rock moisture. Transpiration‐driven diel fluctuations in groundwater were limited to near‐stream areas but were not ubiquitous in space and time. The depth to the groundwater table and the geologic structure at that depth likely dictated rooting depth and thus controlled where and when the transpiration‐driven diel fluctuations were apparent in riparian groundwater. This study outlines the role of hillslope hydrogeology and its influence on the translation of evapotranspiration and soil moisture fluctuations to groundwater and stream fluctuations.
In Situ Estimates of Freezing/Melting Point Depression in Agricultural Soils Using Permittivity and Temperature Measurements
Authors: Pardo Lara R. , Berg A. A. , Warland J. , Tetlock Erica 
Published: March 2020

AbstractWe present a method to characterize soil moisture freeze‐thaw events and freezing/melting point depression using permittivity and temperature measurements, readily available from in situ sources. In cold regions soil freeze‐thaw processes play a critical role in the surface energy and water balance, with implications ranging from agricultural yields to natural disasters. Although monitoring of the soil moisture phase state is of critical importance, there is an inability to interpret soil moisture instrumentation in frozen conditions. To address this gap, we investigated the freeze‐thaw response of a widely used soil moisture probe, the HydraProbe, in the laboratory. Soil freezing curves (SFCs) and soil thawing curves (STCs) were identified using the relationship between soil permittivity and temperature. The permittivity SFC/STC was fit using a logistic growth model to estimate the freezing/melting point depression (Tf/m) and its spread (s). Laboratory results showed that the fitting routine requires permittivity changes greater than 3.8 to provide robust estimates and suggested that a temperature bias is inherent in horizontally placed HydraProbes. We tested the method using field measurements collected over the last 7 years from the Environment and Climate Change Canada and the University of Guelph's Kenaston Soil Moisture Network in Saskatchewan, Canada. By dividing the time series into freeze‐thaw events and then into individual transitions, the permittivity SFC/STC was identified. The freezing and melting point depression for the network was estimated as Tf/m = − 0.35 ± 0.2,with Tf = − 0.41 ± 0.22 °C and Tm = − 0.29 ± 0.16 °C, respectively.
Healable, memorizable, and transformable lattice structures made of stiff polymers
Authors: Yu Kunhao , Du Haixu , Xin An , Lee Kyung Hoon , Feng Zhangzhengrong , Masri Sami F. , Chen Yong , Huang Guoliang , Wang Qiming 
Published: March 2020

AbstractEmerging transformable lattice structures provide promising paradigms to reversibly switch lattice configurations, thereby enabling their properties to be tuned on demand. The existing transformation mechanisms are limited to nonfracture deformation, such as origami, instability, shape memory, and liquid crystallinity. In this study, we present a class of transformable lattice structures enabled by fracture and shape-memory-assisted healing. The lattice structures are additively manufactured with a molecularly designed photopolymer capable of both fracture healing and shape memory. We show that 3D-architected lattice structures with various volume fractions can heal fractures and fully restore stiffness and strength over two to ten healing cycles. In addition, coupled with the shape-memory effect, the lattice structures can recover fracture-associated distortion and then heal fracture interfaces, thereby enabling healing of lattice wing damages, mode-I fractures, dent-induced crashes, and foreign-object impacts. Moreover, by harnessing the coupling of fracture and shape-memory-assisted healing, we demonstrate reversible configuration transformations of lattice structures to enable switching among property states of different stiffnesses, vibration transmittances, and acoustic absorptions. These healable, memorizable, and transformable lattice structures may find broad applications in next-generation aircraft panels, automobile frames, body armor, impact mitigators, vibration dampers, and acoustic modulators.
Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking
Authors: Cresswell George D. , Nichol Daniel , Spiteri Inmaculada , Tari Haider , Zapata Luis , Heide Timon , Maley Carlo C. , Magnani Luca , Schiavon Gaia , Ashworth Alan , Barry Peter , Sottoriva Andrea 
Published: March 2020

AbstractCirculating tumour DNA (ctDNA) allows tracking of the evolution of human cancers at high resolution, overcoming many limitations of tissue biopsies. However, exploiting ctDNA to determine how a patient’s cancer is evolving in order to aid clinical decisions remains difficult. This is because ctDNA is a mix of fragmented alleles, and the contribution of different cancer deposits to ctDNA is largely unknown. Profiling ctDNA almost invariably requires prior knowledge of what genomic alterations to track. Here, we leverage on a rapid autopsy programme to demonstrate that unbiased genomic characterisation of several metastatic sites and concomitant ctDNA profiling at whole-genome resolution reveals the extent to which ctDNA is representative of widespread disease. We also present a methylation profiling method that allows tracking evolutionary changes in ctDNA at single-molecule resolution without prior knowledge. These results have critical implications for the use of liquid biopsies to monitor cancer evolution in humans and guide treatment.
Heat health risk assessment in Philippine cities using remotely sensed data and social-ecological indicators
Authors: Estoque Ronald C. , Ooba Makoto , Seposo Xerxes T. , Togawa Takuya , Hijioka Yasuaki , Takahashi Kiyoshi , Nakamura Shogo 
Published: March 2020

AbstractMore than half of the world’s population currently live in urban areas and are particularly at risk from the combined effects of the urban heat island phenomenon and heat increases due to climate change. Here, by using remotely sensed surface temperature data and social-ecological indicators, focusing on the hot dry season, and applying the risk framework of the Intergovernmental Panel on Climate Change, we assessed the current heat health risk in 139 Philippine cities, which account for about 40% of the country’s total population. The cities at high or very high risk are found in Metro Manila, where levels of heat hazard and exposure are high. The most vulnerable cities are, however, found mainly outside the national capital region, where sensitivity is higher and capacity to cope and adapt is lower. Cities with high levels of heat vulnerability and exposure must be prioritized for adaptation. Our results will contribute to risk profiling in the Philippines and to the understanding of city-level heat health risks in developing regions of the Asia-Pacific.
Universal momentum-to-real-space mapping of topological singularities
Authors: Liu Xiuying , Xia Shiqi , Jajtić Ema , Song Daohong , Li Denghui , Tang Liqin , Leykam Daniel , Xu Jingjun , Buljan Hrvoje , Chen Zhigang 
Published: March 2020

AbstractTopological properties of materials are typically presented in momentum space. Here, we demonstrate a universal mapping of topological singularities from momentum to real space. By exciting Dirac-like cones in photonic honeycomb (pseudospin-1/2) and Lieb (pseudospin-1) lattices with vortex beams of topological charge l, optimally aligned with a given pseudospin state s, we directly observe topological charge conversion that follows the rule l → l + 2s. Although the mapping is observed in photonic lattices where pseudospin-orbit interaction takes place, we generalize the theory to show it is the nontrivial Berry phase winding that accounts for the conversion which persists even in systems where angular momentum is not conserved, unveiling its topological origin. Our results have direct impact on other branches of physics and material sciences beyond the 2D photonic platform: equivalent mapping occurs for 3D topological singularities such as Dirac-Weyl synthetic monopoles, achievable in mechanical, acoustic, or ultracold atomic systems, and even with electron beams.
Cavity electromechanics with parametric mechanical driving
Authors: Bothner D. , Yanai S. , Iniguez-Rabago A. , Yuan M. , Blanter Ya. M. , Steele G. A. 
Published: March 2020

AbstractMicrowave optomechanical circuits have been demonstrated to be powerful tools for both exploring fundamental physics of macroscopic mechanical oscillators, as well as being promising candidates for on-chip quantum-limited microwave devices. In most experiments so far, the mechanical oscillator is either used as a passive element and its displacement is detected using the superconducting cavity, or manipulated by intracavity fields. Here, we explore the possibility to directly and parametrically manipulate the mechanical nanobeam resonator of a cavity electromechanical system, which provides additional functionality to the toolbox of microwave optomechanics. In addition to using the cavity as an interferometer to detect parametrically modulated mechanical displacement and squeezed thermomechanical motion, we demonstrate that this approach can realize a phase-sensitive parametric amplifier for intracavity microwave photons. Future perspectives of optomechanical systems with a parametrically driven mechanical oscillator include exotic bath engineering with negative effective photon temperatures, or systems with enhanced optomechanical nonlinearities.
Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA
Authors: Madru Clément , Henneke Ghislaine , Raia Pierre , Hugonneau-Beaufet Inès , Pehau-Arnaudet Gérard , England Patrick , Lindahl Erik , Delarue Marc , Carroni Marta , Sauguet Ludovic 
Published: March 2020

AbstractReplicative DNA polymerases (DNAPs) have evolved the ability to copy the genome with high processivity and fidelity. In Eukarya and Archaea, the processivity of replicative DNAPs is greatly enhanced by its binding to the proliferative cell nuclear antigen (PCNA) that encircles the DNA. We determined the cryo-EM structure of the DNA-bound PolD–PCNA complex from Pyrococcus abyssi at 3.77 Å. Using an integrative structural biology approach — combining cryo-EM, X-ray crystallography, protein–protein interaction measurements, and activity assays — we describe the molecular basis for the interaction and cooperativity between a replicative DNAP and PCNA. PolD recruits PCNA via a complex mechanism, which requires two different PIP-boxes. We infer that the second PIP-box, which is shared with the eukaryotic Polα replicative DNAP, plays a dual role in binding either PCNA or primase, and could be a master switch between an initiation and a processive phase during replication.
Estimating the size distribution of plastics ingested by animals
Authors: Jâms Ifan B. , Windsor Fredric M. , Poudevigne-Durance Thomas , Ormerod Steve J. , Durance Isabelle 
Published: March 2020

AbstractThe ingestion of plastics appears to be widespread throughout the animal kingdom with risks to individuals, ecosystems and human health. Despite growing information on the location, abundance and size distribution of plastics in the environment, it cannot be assumed that any given animal will ingest all sizes of plastic encountered. Here, we use published data to develop an allometric relationship between plastic consumption and animal size to estimate the size distribution of plastics feasibly ingested by animals. Based on more than 2000 gut content analyses from animals ranging over three orders of magnitude in size (lengths 9 mm to 10 m), body length alone accounts for 42% of the variance in the length of plastic an animal may ingest and indicates a size ratio of roughly 20:1 between animal body length and the largest plastic the animal may ingest. We expect this work to improve global assessments of plastic pollution risk by introducing a quantifiable link between animals and the plastics they can ingest.
Atomically dispersed cobalt catalyst anchored on nitrogen-doped carbon nanosheets for lithium-oxygen batteries
Authors: Wang Peng , Ren Yingying , Wang Rutao , Zhang Peng , Ding Mingjie , Li Caixia , Zhao Danyang , Qian Zhao , Zhang Zhiwei , Zhang Luyuan , Yin Longwei 
Published: March 2020

AbstractDeveloping single-site catalysts featuring maximum atom utilization efficiency is urgently desired to improve oxidation-reduction efficiency and cycling capability of lithium-oxygen batteries. Here, we report a green method to synthesize isolated cobalt atoms embedded ultrathin nitrogen-rich carbon as a dual-catalyst for lithium-oxygen batteries. The achieved electrode with maximized exposed atomic active sites is beneficial for tailoring formation/decomposition mechanisms of uniformly distributed nano-sized lithium peroxide during oxygen reduction/evolution reactions due to abundant cobalt-nitrogen coordinate catalytic sites, thus demonstrating greatly enhanced redox kinetics and efficiently ameliorated over-potentials. Critically, theoretical simulations disclose that rich cobalt-nitrogen moieties as the driving force centers can drastically enhance the intrinsic affinity of intermediate species and thus fundamentally tune the evolution mechanism of the size and distribution of final lithium peroxide. In the lithium-oxygen battery, the electrode affords remarkably decreased charge/discharge polarization (0.40 V) and long-term cyclability (260 cycles at 400 mA g−1).
Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
Authors: Ou Xiuyuan , Liu Yan , Lei Xiaobo , Li Pei , Mi Dan , Ren Lili , Guo Li , Guo Ruixuan , Chen Ting , Hu Jiaxin , Xiang Zichun , Mu Zhixia , Chen Xing , Chen Jieyong , Hu Keping , Jin Qi , Wang Jianwei , Qian Zhaohui 
Published: March 2020

AbstractSince 2002, beta coronaviruses (CoV) have caused three zoonotic outbreaks, SARS-CoV in 2002–2003, MERS-CoV in 2012, and the newly emerged SARS-CoV-2 in late 2019. However, little is currently known about the biology of SARS-CoV-2. Here, using SARS-CoV-2 S protein pseudovirus system, we confirm that human angiotensin converting enzyme 2 (hACE2) is the receptor for SARS-CoV-2, find that SARS-CoV-2 enters 293/hACE2 cells mainly through endocytosis, that PIKfyve, TPC2, and cathepsin L are critical for entry, and that SARS-CoV-2 S protein is less stable than SARS-CoV S. Polyclonal anti-SARS S1 antibodies T62 inhibit entry of SARS-CoV S but not SARS-CoV-2 S pseudovirions. Further studies using recovered SARS and COVID-19 patients’ sera show limited cross-neutralization, suggesting that recovery from one infection might not protect against the other. Our results present potential targets for development of drugs and vaccines for SARS-CoV-2.
The biofilm-associated surface protein Esp of Enterococcus faecalis forms amyloid-like fibers
Authors: Taglialegna Agustina , Matilla-Cuenca Leticia , Dorado-Morales Pedro , Navarro Susanna , Ventura Salvador , Garnett James A. , Lasa Iñigo , Valle Jaione 
Published: March 2020

AbstractFunctional amyloids are considered as common building block structures of the biofilm matrix in different bacteria. In previous work, we have shown that the staphylococcal surface protein Bap, a member of the Biofilm-Associated Proteins (BAP) family, is processed and the fragments containing the N-terminal region become aggregation-prone and self-assemble into amyloid-like structures. Here, we report that Esp, a Bap-orthologous protein produced byEnterococcus faecalis, displays a similar amyloidogenic behavior. We demonstrate that at acidic pH the N-terminal region of Esp forms aggregates with an amyloid-like conformation, as evidenced by biophysical analysis and the binding of protein aggregates to amyloid-indicative dyes. Expression of a chimeric protein, with its Esp N-terminal domain anchored to the cell wall through the R domain of clumping factor A, showed that the Esp N-terminal region is sufficient to confer multicellular behavior through the formation of an extracellular amyloid-like material. These results suggest that the mechanism of amyloid-like aggregation to build the biofilm matrix might be widespread among BAP-like proteins. This amyloid-based mechanism may not only have strong relevance for bacteria lifestyle but could also contribute to the amyloid burden to which the human physiology is potentially exposed.