bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effective Internal and External Modulation of Nontraditional Intrinsic Luminescence
Authors: Lai Yueying , Zhu Tianwen , Geng Ting , Zheng Shuyuan , Yang Tianjia , Zhao Zihao , Xiao Guanjun , Zou Bo , Yuan Wang Zhang 
Published: November 2020

AbstractThe rational modulation of the nontraditional intrinsic luminescence (NTIL) of nonconventional luminophores remains difficult, on account of the limited understanding on the structure–property relationships and emission mechanisms. Herein, the effective modulation of NTIL is demonstrated based on a group of nonaromatic anhydrides and imides. Mutual bridging of isolated subgroups effectively promotes intramolecular through‐space conjugation (TSC), leading to red‐shifted emission, enhanced efficiency, and prolonged persistent room‐temperature phosphorescence (p‐RTP). The substitution of heteroatoms from oxygen to nitrogen drastically changes the TSC and enhances intermolecular interactions, resulting in enhanced emission efficiency. In addition, upon freezing, compression, or embedding into polymer matrices, the emission intensity and color remain well regulated. These results shed new light on the rational modulation of the NTIL and p‐RTP of nonconventional luminophores.
A Reactive Oxygen Species Scavenging and O2 Generating Injectable Hydrogel for Myocardial Infarction Treatment In vivo
Authors: Ding Jie , Yao Yuejun , Li Jiawei , Duan Yiyuan , Nakkala Jayachandra Reddy , Feng Xue , Cao Wangbei , Wang Yingchao , Hong Liangjie , Shen Liyin , Mao Zhengwei , Zhu Yang , Gao Changyou 
Published: November 2020

AbstractThe excessive reactive oxygen species (ROS) and hypoxia deteriorate the inflammation‐related diseases such as myocardial infarction (MI), and thereby deter the normal tissue repair and recovery and further lead to severe fibrosis and malfunction of tissues and organs. In particular, the MI has become one of the leading causes of death nowadays. In this study, a novel type of injectable hydrogel with dual functions of ROS scavenging and O2 generating is fabricated for MI treatment in vivo. The hydrogel is formed within 3 s from the synthetic ROS‐cleavable hyperbranched polymers and methacrylate hyaluronic acid (HA‐MA) under UV‐irradiation. Addition of biocompatible and applicable catalase in vivo enables the further transition of H2O2, a major type of ROS, to O2 and H2O. Results of rat MI model demonstrate that this hydrogel can significantly remove excessive ROS, inhibit cell apoptosis, increase M2/M1 macrophage ratio, promote angiogenesis, reduce infarcted area, and improve cardiac functions. With the appropriate degradation rate, simple structure and composition without cell seeding, and very excellent MI therapeutic effect, this ROS scavenging and O2 generating hydrogel has a great promise to be applied clinically.
Petz map and Python’s lunch
Authors: Zhao Ying 
Published: November 2020

Abstract
We look at the interior operator reconstruction from the point of view of Petz map and study its complexity. We show that Petz maps can be written as precursors under the condition of perfect recovery. When we have the entire boundary system its complexity is related to the volume/action of the wormhole from the bulk operator to the boundary. When we only have access to part of the system, Python’s lunch appears and its restricted complexity depends exponentially on the size of the subsystem one loses access to.
Long non-coding RNAs in lung cancer: implications for lineage plasticity-mediated TKI resistance
Authors: Liu Tongyan , Han Chencheng , Fang Panqi , Zhu Hongyu , Wang Siwei , Ma Zhifei , Zhang Quanli , Xia Wenjia , Wang Jie , Xu Lin , Yin Rong 
Published: November 2020

AbstractThe efficacy of targeted therapy in non-small-cell lung cancer (NSCLC) has been impeded by various mechanisms of resistance. Besides the mutations in targeted oncogenes, reversible lineage plasticity has recently considered to play a role in the development of tyrosine kinase inhibitors (TKI) resistance in NSCLC. Lineage plasticity enables cells to transfer from one committed developmental pathway to another, and has been a trigger of tumor adaptation to adverse microenvironment conditions including exposure to various therapies. More importantly, besides somatic mutation, lineage plasticity has also been proposed as another source of intratumoural heterogeneity. Lineage plasticity can drive NSCLC cells to a new cell identity which no longer depends on the drug-targeted pathway. Histological transformation and epithelial–mesenchymal transition are two well-known pathways of lineage plasticity-mediated TKI resistance in NSCLC. In the last decade, increased re-biopsy practice upon disease recurrence has increased the recognition of lineage plasticity induced resistance in NSCLC and has improved our understanding of the underlying biology. Long non-coding RNAs (lncRNAs), the dark matter of the genome, are capable of regulating variant malignant processes of NSCLC like the invisible hands. Recent evidence suggests that lncRNAs are involved in TKI resistance in NSCLC, particularly in lineage plasticity-mediated resistance. In this review, we summarize the mechanisms of lncRNAs in regulating lineage plasticity and TKI resistance in NSCLC. We also discuss how understanding these themes can alter therapeutic strategies, including combination therapy approaches to overcome TKI resistance.
Complete Lymphadenectomy Around the Entire Superior Mesenteric Artery Improves Survival in Artery‐First Approach Pancreatoduodenectomy for T3 Pancreatic Ductal Adenocarcinoma
Authors: Kobayashi Shinjiro , Otsubo Takehito , Nakano Hiroshi , Koizumi Satoshi , Nakahara Kazunari 
Published: November 2020

AbstractBackgroundArtery‐first approach pancreatoduodenectomy (AFA‐PD) is an important technique for treating pancreatic ductal adenocarcinoma (PDAC). However, it remains unknown whether performing complete lymphadenectomy around the entire superior mesenteric artery (SMA) is associated with better outcomes. In this retrospective study, we aimed to investigate whether this approach improved overall and recurrence‐free survival in patients with PDAC.MethodsWe identified 88 patients with T3 PDAC who underwent PD at St. Marianna University School of Medicine, Kawasaki, Japan, between April 2005 and October 2017. Two groups were defined: an “AFA‐PD group” (n = 45) who had undergone AFA‐PD in addition to complete lymphadenectomy around the entire SMA, and a “conventional PD group” (n = 43) in whom complete lymphadenectomy had not been performed (conventional group). Univariate and multivariate survival analyses were performed to identify risk factors for overall and disease‐free survival.ResultsThe AFA‐PD group had a longer median survival time (40.3 vs. 22.6 months; p = 0.0140) and a higher 5‐year survival rate (40.3% vs. 5.9%, p = 0.005) than the conventional PD group. Multivariate analysis showed that AFA‐PD with complete lymphadenectomy around the entire SMA was an independent factor for improved overall survival (p = 0.022). Recurrences around the SMA were significantly less frequent in the AFA‐PD group than in the conventional group (22.2% vs. 44.2%, p = 0.041).ConclusionsAFA‐PD with complete lymphadenectomy around the entire SMA can prevent recurrences around the SMA and may prolong overall survival in patients with PDAC.
The first records of Spirometra erinaceieuropaei (Cestoda: Diphyllobothriidae), a causative agent of human sparganosis, in Latvian wildlife
Authors: Bagrade Guna , Králová-Hromadová Ivica , Bazsalovicsová Eva , Radačovská Alžbeta , Kołodziej-Sobocińska Marta 
Published: November 2020

AbstractDiphyllobothriid tapeworms of the genus Spirometra are causative agents of sparganosis, food-borne zoonotic parasitic disease. They have been recorded in broad spectrum of hosts, including humans, in all continents except Antarctica. Spirometra tapeworms have been intensively studied in several Asian countries; however, they have been rather neglected in Europe. The aim of this study was to provide a pilot screening of Spirometra spp. in Latvia, where data on sparganosis are not available. Tapeworms morphologically identified as diphyllobothriid species were isolated from grey wolves Canis lupus and Eurasian lynxes Lynx lynx from Latvia during the hunting periods 2013–2019. The parasites were subjected to molecular genotyping using sequences of the partial large (LSU rDNA; 615 bp) and small (SSU rDNA; 720 bp) subunits of the nuclear ribosomal RNA gene and complete (1566 bp) cytochrome c oxidase subunit I gene of the mitochondrial DNA (cox1 mtDNA). Analyses of both ribosomal subunits of 13 tapeworms revealed no intraspecific variation within the respective rDNA subunits. On the other hand, sequence analysis of mitochondrial cox1 revealed intraspecific polymorphism displayed by 12 cox1 haplotypes. Comparison of the current data with sequences of the corresponding DNA regions deposited in the GenBank revealed 99.3–99.5% (LSU rDNA), 99.2% (SSU rDNA) and 99.6–100% (cox1 mtDNA) identity of studied tapeworms with Spirometra erinaceieuropaei, which provided the first confirmation of this diphyllobothriid tapeworm in Latvia. Since S. erinaceieuropaei is probably prevalent in Latvian wildlife and may also occur in other potential host species, further studies are needed in order to acquire complex data on its geographic distribution and transmission in the natural environment of Latvia, as well as on the spectrum of its intermediate, paratenic, and definitive hosts.
The basal dunite of the Precambrian mafic-ultramafic Näränkävaara intrusion: Petrogenetic considerations and implications to exploration
Authors: Järvinen Ville , Halkoaho Tapio , Konnunaho Jukka , Heinonen Jussi S. , Rämö O. Tapani 
Published: November 2020

AbstractSeveral mafic-ultramafic layered intrusions were emplaced in the Fennoscandian Shield during wide-spread mantle-sourced magmatism at 2.5–2.4 Ga. The Näränkävaara intrusion (surface area 5 × 30 km2), northeastern Finland, contains a 1.5–2 km thick basal dunite (not dated), and a 1.5 km thick layered series (2436 ± 5 Ma). A newly discovered marginal series between the basal dunite and the layered series indicates that the basal dunite is older, and highlights the need for further study on their relationship. Along its southern basement contact, the basal dunite contains a 200–300 m thick zone of olivine ortho- and mesocumulates, but the bulk of it is composed of olivine adcumulates and lesser olivine-orthopyroxene heteradcumulates. Based on whole-rock geochemistry, the basal dunite is divided into a low-Fe zone (average FeOt 10.2 wt% and Ni 2250 ppm) and a high-Fe zone (average FeOt 12.5 wt% and Ni 1700 ppm). Both zones have high MgO (32–47 wt%) and varying Cr (830–5160 ppm) and Al2O3/TiO2 (16–26). Textural and geochemical layering is similar along the 30 km strike of the basal dunite. A LREE-enriched high-MgO basaltic parental magma composition (13–18 wt% MgO) is inferred for the basal dunite from olivine–melt mixing trends in orthocumulates. The dunite exhibits at least two geochemical reversals as well as abundant low-porosity adcumulates, poikilitic chromite, and bimodal olivine, suggesting formation in a high-volume open magmatic system. Significant similarity in major and trace element compositions with the Näränkävaara layered series and the Burakovsky intrusion and Vetreny belt extrusives in Russian Karelia suggests that the basal dunite belongs to the Fennoscandian 2.5–2.4 Ga mafic layered intrusions. An Archean komatiitic origin for the dunite body cannot be completely ruled out, however. Distinct Ni-depletion in olivine is found in the basal dunite from the low-Fe zone to the high-Fe zone (3200 versus 2200 ppm). This depletion does not correlate with Fo contents, which suggests that it is not related to olivine fractionation. The basal dunite may thus have potential for Ni-(Cu-Co-PGE) sulfide mineralization.
Arthropod spatial cognition
Authors: Pfeffer Sarah , Wolf Harald 
Published: November 2020

AbstractThe feats of arthropods, and of the well-studied insects and crustaceans in particular, have fascinated scientists and laymen alike for centuries. Arthropods show a diverse repertoire of cognitive feats, of often unexpected sophistication. Despite their smaller brains and resulting lower neuronal capacity, the cognitive abilities of arthropods are comparable to, or may even exceed, those of vertebrates, depending on the species compared. Miniature brains often provide parsimonious but smart solutions for complex behaviours or ecologically relevant problems. This makes arthropods inspiring subjects for basic research, bionics, and robotics. Investigations of arthropod spatial cognition have originally concentrated on the honeybee, an animal domesticated for several thousand years. Bees are easy to keep and handle, making this species amenable to experimental study. However, there are an estimated 5–10 million arthropod species worldwide, with a broad diversity of lifestyles, ecology, and cognitive abilities. This high diversity provides ample opportunity for comparative analyses. Comparative study, rather than focusing on single model species, is well suited to scrutinise the link between ecological niche, lifestyle, and cognitive competence. It also allows the discovery of general concepts that are transferable between distantly related groups of organisms. With species diversity and a comparative approach in mind, this special issue compiles four review articles and ten original research reports from a spectrum of arthropod species. These contributions range from the well-studied hymenopterans, and ants in particular, to chelicerates and crustaceans. They thus present a broad spectrum of glimpses into current research on arthropod spatial cognition, and together they cogently emphasise the merits of research into arthropod cognitive achievements.
Seismic response of a masonry church in Central Italy: the role of interventions on the roof
Authors: Sferrazza Papa Gessica , Tateo Vito , Parisi Maria Adelaide , Casolo Siro 
Published: November 2020

AbstractThe seismic response of a medieval church in Central Italy is analyzed considering the two roof configurations, i.e., reinforced concrete and timber roofs, that the church had in different periods of its existence. Structural interventions and changes are common in the churches of this territory, where frequent earthquakes put these buildings at risk. The church studied here, St. Salvatore in Acquapagana (Serravalle di Chienti, province of Macerata), was damaged by the 1997 Umbria-Marche and the 2016 Central Italy earthquakes. Between these two seismic events, the church was repaired, and the concrete roof was substituted with a lighter timber roof. To investigate the influence of this change on the seismic response, a study was performed at the building and façade macroelement scales using the finite element model and rigid body spring model, respectively. For each approach, the two roof configurations were considered, and two strong motion records, from September 26, 1997, and October 30, 2016, were applied. The results show that the concrete roof improves the box-like behavior, but it increases the vulnerability of the masonry structures, characterized by a limited tensile strength. Conversely, in the timber roof configuration, the most vulnerable areas of the structure are the intersections between structural elements.
Non-invasive measurement of pulse pressure variation using a finger-cuff method in obese patients having laparoscopic bariatric surgery
Authors: Flick Moritz , Schumann Roman , Hoppe Phillip , Bonney Iwona , Wesselink Wilbert , Saugel Bernd 
Published: November 2020

AbstractPulse pressure variation (PPV) is a dynamic cardiac preload variable used to predict fluid responsiveness. PPV can be measured non-invasively using innovative finger-cuff systems allowing for continuous arterial pressure waveform recording, e.g., the Nexfin system [BMEYE B.V., Amsterdam, The Netherlands; now Clearsight (Edwards Lifesciences, Irvine, CA, USA)] (PPVFinger). However, the agreement between PPVFinger and PPV derived from an arterial catheter (PPVART) in obese patients having laparoscopic bariatric surgery is unknown. We compared PPVFinger and PPVART at 6 time points in 60 obese patients having laparoscopic bariatric surgery in a secondary analysis of a prospective method comparison study. We used Bland–Altman analysis to assess absolute agreement between PPVFinger and PPVART. The predictive agreement for fluid responsiveness between PPVFinger and PPVART was evaluated across three PPV categories (PPV < 9%, PPV 9–13%, PPV > 13%) as concordance rate of paired measurements and Cohen’s kappa. The overall mean of the differences between PPVFinger and PPVART was 0.5 ± 4.6% (95%-LoA − 8.6 to 9.6%) and the overall predictive agreement was 72.4% with a Cohen’s kappa of 0.53. The mean of the differences was − 0.7 ± 3.8% (95%-LoA − 8.1 to 6.7%) without pneumoperitoneum in horizontal position and 1.1 ± 4.8% (95%-LoA − 8.4 to 10.5%) during pneumoperitoneum in reverse-Trendelenburg position. The absolute agreement and predictive agreement between PPVFinger and PPVART are moderate in obese patients having laparoscopic bariatric surgery.
Korean video dataset for emotion recognition in the wild
Authors: Khanh Trinh Le Ba , Kim Soo-Hyung , Lee Gueesang , Yang Hyung-Jeong , Baek Eu-Tteum 
Published: November 2020

AbstractEmotion recognition is one of the hottest fields in affective computing research. Recognizing emotions is an important task for facilitating communication between machines and humans. However, it is a very challenging task based on a lack of ethnically diverse databases. In particular, emotional expressions tend to be very dissimilar between Western and Eastern people. Therefore, diverse emotion databases are required for studying emotional expression. However, majority of the well-known emotion databases focus on Western people, which exhibit different characteristics compared to Eastern people. In this study, we constructed a novel emotion dataset containing more than 1200 video clips collected from Korean movies, called Korean Video Dataset for Emotion Recognition in the Wild (KVDERW). Which are similar to real-world conditions, with the goal of studying the emotions of Eastern people, particularly Korean people. Additionally, we developed a semi-automatic video emotion labelling tool that could be used to generate video clips and annotate the emotions in clips.
Kinetic compensation effect of isoconversional methods
Authors: Mianowski Andrzej , Radko Tomasz , Siudyga Tomasz 
Published: November 2020

AbstractFor experimental data obtained under different reaction/process conditions over time or temperature, the kinetic compensation effect (KCE) can be expected. Under dynamic (nonisothermal) conditions, at least two analytical pathways forming the KCE were found. Constant heating rate (q = const) and variable conversion degrees (α = var) lead to a vertical source of the KCE, called the isochronal effect. In turn, for a variable heating rate (q = var) and constant conversion degree (α = const), we can obtain an isoconversional compensation effect. In isothermal conditions (analyzed as polyisothermal), the KCE appears only as an isoconversional source of the compensating effect. The scattering of values for the determined isokinetic temperatures is evidence of a strong influence of the experimental conditions and the calculation methodology. The parameters of the Arrhenius law have been shown to allow the determination of the KCE and further the isokinetic temperature. In turn, using the Eyring equations for the same parameters, we can determine the enthalpy–entropy compensation (EEC) for the activation process and the compensation temperature, which is often treated as an isokinetic temperature. KCE effects have also been shown to be able to be amplified or dissipated, but isokinetic temperature is not a compensating quantity in the literal sense in isoconversional methods because$${T}_{iso}\to \infty .$$Tiso→∞.Thus, in isoconversional methods, isoconversional KCE values are characterized by strong variability of activation energy corresponding to the weak variation of the pre-exponential factor, which in practice means that$${\text{ln}}\mathit {A}\to {\text{const}}.$$lnA→const.This is completely in line with the classical Arrhenius law.
Combined visual and biochemical analyses confirm depositor and diet for Neolithic coprolites from Skara Brae
Authors: Romaniuk Andrzej A. , Panciroli Elsa , Buckley Michael , Pal Chowdhury Manasij , Willars Carla , Herman Jeremy S. , Troalen Lore G. , Shepherd Alexandra N. , Clarke David V. , Sheridan Alison , van Dongen Bart E. , Butler Ian B. , Bendrey Robin 
Published: November 2020

AbstractCoprolites (fossilized faeces) can provide valuable insights into species’ diet and related habits. In archaeozoological contexts, they are a potential source of information on human-animal interactions as well as human and animal subsistence. However, despite a broad discussion on coprolites in archaeology, such finds are rarely subject to detailed examination by researchers, perhaps due to the destructive nature of traditional analytical methods. Here, we have examined coprolitic remains from the Neolithic (third millennium BCE) settlement at Skara Brae, Orkney, using a range of modern methods: X-ray computed tomography, scanning electron microscopy, lipid and protein analysis (shotgun proteomics of the coprolite matrix as well as collagen peptide mass fingerprinting of isolated bone fragments). This combined approach minimised destructiveness of sampling, leaving sufficient material for subsequent study, while providing more information than traditional morphological examination alone. Based on gross visual examination, coprolites were predominantly attributed to domestic dogs (Canis familiaris), with morphologically identified bone inclusions derived from domestic sheep (Ovis aries) and common voles (Microtus arvalis). Partial dissection of a coprolite provided bone samples containing protein markers akin to those of domestic sheep. Considering the predominance of vertebral and distal limb bone fragments, Skara Brae dogs were probably consuming human butchery or meal refuse, either routinely fed to them or scavenged. The presumably opportunistic consumption of rodents may also have played a role in pest control.
Konturen einer Weiterentwicklung der Didaktik für Sozialpädagogik
Authors: Sauerwein Markus N. 
Published: November 2020

ZusammenfassungAngesichts des zunehmenden Einflusses von Scholarisierungsprozessen auf sozialpädagogische Arbeitsfelder und einer damit einhergehenden Kompetenzorientierung, diskutiert der Beitrag die hieraus resultierenden Herausforderungen für eine Didaktik der Sozialpädagogik. Es darf diagnostiziert werden, dass trotz eines immensen Bedarfs an Lehrkräften für Sozialpädagogik, die Didaktik der Sozialpädagogik überraschend wenig Aufmerksamkeit erhält, sowohl in wissenschaftlichen Publikationen aber auch in den Fachschulen für Sozialpädagogik, denn Sozialpädagogik wird zumeist fachfremd unterrichtet. Ein Überblick des gegenwärtigen Diskussionsstandes zeigt, dass zwar Unterrichtsprinzipien und Lehrmethoden einer Didaktik der Sozialpädagogik benannt werden, es aber an eine Qualitätsdiskussion fehlt. Auch findet kein Bezug auf dahinterliegende professionstheoretische Verständnisse statt. Der Beitrag greift dies auf und argumentiert, dass Kompetenzorientierung in der Erzieher*innen-Ausbildung zwar durchaus kritisch betrachtet werden kann, letztlich jedoch nicht zu ignorieren ist. Um hierauf angemessen zu reagieren, sollte die Didaktik der Sozialpädagogik schulpädagogische Konzepte zur Kenntnis nehmen, um eine spezifische sozialpädagogische Antwort auf die Kompetenzorientierung zu entwickeln. Diese könnte etwa in der Entwicklung ‚sozialpädagogischer Dimensionen guten Unterrichts‘ für Fachschulen für Erzieher*innen bestehen. Zudem sollten Kompetenzen nicht über standardisierte Tests erhoben werden, sondern in der Bearbeitung der Antinomien des beruflichen Handelns, die auf unterschiedlichen Niveaustufen erfolgen kann.