bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative meta-analyses of brain structural and functional abnormalities during cognitive control in attention-deficit/hyperactivity disorder and autism spectrum disorder
Authors: Lukito Steve , Norman Luke , Carlisi Christina , Radua Joaquim , Hart Heledd , Simonoff Emily , Rubia Katya 
Published: March 2020

AbstractBackgroundPeople with attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) have abnormalities in frontal, temporal, parietal and striato-thalamic networks. It is unclear to what extent these abnormalities are distinctive or shared. This comparative meta-analysis aimed to identify the most consistent disorder-differentiating and shared structural and functional abnormalities.MethodsSystematic literature search was conducted for whole-brain voxel-based morphometry (VBM) and functional magnetic resonance imaging (fMRI) studies of cognitive control comparing people with ASD or ADHD with typically developing controls. Regional gray matter volume (GMV) and fMRI abnormalities during cognitive control were compared in the overall sample and in age-, sex- and IQ-matched subgroups with seed-baseddmapping meta-analytic methods.ResultsEighty-six independent VBM (1533 ADHD and 1295 controls; 1445 ASD and 1477 controls) and 60 fMRI datasets (1001 ADHD and 1004 controls; 335 ASD and 353 controls) were identified. The VBM meta-analyses revealed ADHD-differentiatingdecreasedventromedial orbitofrontal (z= 2.22,p< 0.0001) but ASD-differentiatingincreasedbilateral temporal and right dorsolateral prefrontal GMV (zs ⩾ 1.64,ps ⩽ 0.002). The fMRI meta-analyses of cognitive control revealed ASD-differentiating medial prefrontal underactivation but overactivation in bilateral ventrolateral prefrontal cortices and precuneus (zs ⩾ 1.04,ps ⩽ 0.003). During motor response inhibition specifically, ADHD relative to ASD showed right inferior fronto-striatal underactivation (zs ⩾ 1.14,ps ⩽ 0.003) but shared right anterior insula underactivation.ConclusionsPeople with ADHD and ASD have mostly distinct structural abnormalities, with enlarged fronto-temporal GMV in ASD and reduced orbitofrontal GMV in ADHD; and mostly distinct functional abnormalities, which were more pronounced in ASD.
Explaining second language utterance fluency: Contribution of cognitive fluency and first language utterance fluency
Authors: Kahng Jimin 
Published: March 2020

AbstractGiven that utterance fluency in a second language (L2) is associated with not only L2 cognitive fluency but also utterance fluency in the first language (L1), the study examined to what extent different measures of L2 utterance fluency can be explained by L2-specific cognitive fluency and/or the corresponding L1 utterance fluency measures. Utterance fluency measures on speed, breakdown, and repair phenomena and cognitive fluency measures including speed of lexical retrieval, syntactic encoding, and articulation were collected in the L1 and the L2 from 44 Chinese learners of English. The results show that most L2 utterance fluency measures are accounted for by the combination of L2-specific cognitive fluency measures and the equivalent L1 utterance fluency measure, whereas the number of mid-clause silent pauses and corrections, and mean syllable duration are largely explained by L2-specific cognitive measures, suggesting that they reflect L2-specific knowledge and cognitive skills. In contrast, mean silent pause duration and the number of filled pauses are mainly explained by the corresponding L1 utterance fluency measures.
Small mammals in fragments of Atlantic Forest: species richness answering to field methods and environment
Authors: Rodrigues Daniele Pereira , Skupien Fabrício Luiz , de Oliveira Sausen Jady , Lima Daniela Oliveira de 
Published: March 2020

AbstractSmall mammals can be used as environmental indicators and have been intensively studied in fragmented landscapes of Atlantic Forest, with a wide range of field methods. Our aim in this study was two-fold: we tested for the effects of methods and for the effects of the main environmental variables on observed small mammal richness in fragments of Atlantic Forest. We gathered information on small mammal richness, methods and environmental variables from 122 fragments of Atlantic Forest through literature review. These data were analysed using linear models and model selection based on AIC values along with a regression tree analysis. We found that studies will record more species with bigger trapping effort, using pitfall traps and sampling all forest strata. We also confirmed two important ecological assumptions: fragments at lower latitudes and bigger fragments were the ones with higher species richness. Methodological and environmental variables were analysed together on a regression tree, where trapping effort was the most important variable, surpassing any environmental effect. Considering that a significant number of the studies on Atlantic Forest fragments did not use pitfall traps or sample all forest strata, their results on forest fragmentation were affected by sampling bias.
Relationship between different levels of the Mexican food environment and dietary intake: a qualitative systematic review
Authors: Rosales Chavez Jose B , Garcia Lucia M , Jehn Megan , Pereira Mark A , Bruening Meg 
Published: March 2020

AbstractObjective:To investigate the possible associations between the food environment and dietary intake in the Mexican population.Design:Four databases (PubMed, PsychInfo, Web of Science and SCIelo) were used to retrieve relevant articles using an open timeframe. Articles were reviewed if they contained a systematic measure (i.e. food checklist) of the food environment (e.g. food availability) and dietary intake.Setting:Urban and rural communities in Mexico.Participants:Population-based studies of Mexican communities.Results:Twenty studies that assessed at least one food environment level, and at least one dietary outcome, were reviewed. Findings from these studies showed that changes in the Mexican food environment seem to be associated with higher availability of energy-dense foods. Energy-dense foods can be linked to a high consumption in household, environment and community food environments. When both nutrient-dense and energy-dense foods were present, individuals were more likely to consume foods with added sugars, fats and salt options than nutrient-dense items.Conclusions:The various levels of the food environment (i.e. household, school, community) exposed participants to energy-dense foods. Although nutrient-dense foods were present in all three levels, individuals were more likely to consume energy-dense food items. Not all three levels of the food environment are well represented in the urban and rural settings. Most studies on the community food environment were done in rural areas, whereas most studies on the school food environment were done in urban settings. Additional rigorously designed studies are needed to document the relationship between the food environment and dietary intake in the Mexican population.
Effects of Heat‐Producing Elements on the Stability of Deep Mantle Thermochemical Piles
Authors: Citron Robert I. , Lourenço Diogo L. , Wilson Alfred J. , Grima Antoniette G. , Wipperfurth Scott A. , Rudolph Maxwell L. , Cottaar Sanne , Montési Laurent G. J. 
Published: March 2020

AbstractGeochemical observations of ocean island and mid‐ocean ridge basalts suggest that abundances of heat‐producing elements (HPEs: U, Th, and K) vary within the mantle. Combined with bulk silicate Earth models and constraints on the Earth's heat budget, these observations suggest the presence of a more enriched (potentially deep and undepleted) reservoir in the mantle. Such a reservoir may be related to seismically observed deep mantle structures known as large low shear velocity provinces (LLSVPs). LLSVPs might represent thermochemical piles of an intrinsically denser composition, and many studies have shown such piles to remain stable over hundreds of Myr or longer. However, few studies have examined if thermochemical piles can remain stable if they are enriched in HPEs, a necessary condition for them to constitute an enriched HPE reservoir. We conduct a suite of mantle convection simulations to examine the effect of HPE enrichment up to 25× the ambient mantle on pile stability. Model results are evaluated against present‐day pile morphology and tested for resulting seismic signatures using self‐consistent potential pile compositions. We find that stable piles can form from an initial basal layer of dense material even if the layer is enriched in HPEs, depending on the density of the layer and degree of HPE enrichment, with denser basal layers requiring increased HPE enrichment to form pile‐like morphology instead of a stable layer. Thermochemical piles or LLSVPs may therefore constitute an enriched reservoir in the deep mantle.
Latitudinal Dependence of the Kelvin‐Helmholtz Instability and Beta Dependence of Vortex‐Induced High‐Guide Field Magnetic Reconnection
Authors: Vernisse Y. , Lavraud B. , Faganello M. , Fadanelli S. , Sisti M. , Califano F. , Eriksson S. , Gershman D. J. , Dorelli J. , Pollock C. , Giles B. , Avanov L. , Burch J. , Dargent J. , Ergun R. E. , Farrugia C. J. , Génot V. , Hasegawa H. , Jacquey C. , Kacem I. , Kieokaew R. , Kuznetsova M. , Moore T. , Nakamura T. , Paterson W. , Penou E. , Phan T. D. , Russell C. T. , Saito Y. , Sauvaud J.‐A. , Toledo‐Redondo S. 
Published: March 2020

AbstractWe investigate both large‐ and small‐scale properties of a Kelvin‐Helmholtz (KH) event at the dusk flank magnetopause using Magnetospheric Multiscale observations on 8 September 2015. We first use two types of 3‐D simulations (global and local) to demonstrate that Magnetospheric Multiscale is close to the most KH unstable region, and so the occurrence of vortex‐induced reconnection may be expected. Because they produce low‐shear current sheets, KH vortices constitute a perfect laboratory to investigate magnetic reconnection with large guide field and low asymmetry. Recent works suggest that magnetic reconnection may be suppressed when a current sheet combines large guide field and pressure gradient (which induces a diamagnetic drift). We thus perform a statistical analysis of high‐resolution data for the 69 KH‐induced low‐shear magnetic reconnection events observed on that day. We find that the suppression mechanism is not at work for most of the observed reconnecting current sheets, as predicted, but we also find that almost all nonreconnecting current sheets should be reconnecting according to this model. This confirms the fact that the model provides a necessary but not sufficient condition for reconnection to occur. Finally, based on the same data set, we study the latitudinal distribution of these magnetic reconnection events combined with global magnetospheric modeling. We find that reconnection associated with KH vortices occurs over a significant range of latitudes at the flank magnetopause. It is not confined to the plane where the growth rate is maximum, in agreement with recent 3‐D simulations.
Rift Structure and Sediment Infill of Hyperextended Continental Crust: Insights From 3D Seismic and Well Data (Xisha Trough, South China Sea)
Authors: Lei Chao , Alves Tiago M. , Ren Jianye , Tong Chuanxin 
Published: March 2020

AbstractThree‐dimensional seismic and well data from the deepwater Xisha Trough are used to investigate the rift structure and sediment infill of a region formed adjacently to the initial oceanic ridge of the South China Sea (SCS). The high‐quality data permitted a detailed analysis of features such as (1) detachment faults soling out at the Moho, (2) rotated and thinned continental blocks covered by thick sediment, and (3) changes in the location of basin depocenters resulting from detachment faulting. During the continental rifting phase (Eocene to earliest Oligocene), faulting was broadly distributed in the Xisha Trough and resulted in the generation of isolated grabens/half grabens filled by proximal sediment sources. During continental breakup in the Northwest Ocean Sector of SCS (Oligocene), extension became restricted to a narrow region where highly tilted continental blocks and thin crust were formed. Sediment was, at that time, fed to distal depocenters, which are presently bounded by listric faults rooted in a basal detachment. Later in a second stage (early Miocene), synchronously with continental breakup in the Southwest Ocean Sector of the SCS, the study area was blanketed by thick sediment. During the two continental breakup events, the hyperextended Xisha Trough was affected by closely spaced, small‐scale faults rather than large basement‐related structures. Our study highlights the effect of continental breakup as a way to broaden sediment influx from multiple sources into deepwater basins. As a corollary, this work recognizes two distinct breakup sequences in the Xisha Trough and concludes on their geodynamic significance to the SCS.
Snow Water Equivalent Measurements in Remote Arctic Alaska Watersheds
Authors: Stuefer S. L. , Kane D. L. , Dean K. M. 
Published: March 2020

AbstractSnow surveys in two Arctic watersheds located in Alaska, USA, provide 32 years of spatially distributed snow water equivalent (SWE) and snow depth observations. Annual snow surveys from the Imnavait Creek (20,036 measurements from 1985 to 2017) and Upper Kuparuk River (5,804 measurements from 1997 to 2017) watersheds were conducted to capture end‐of‐winter snow accumulation. The average end‐of‐winter SWE in the Upper Kuparuk River watershed (102 ± 29 mm) is consistently less than the Imnavait Creek watershed (130 ± 34 mm) during the common period of record (1997–2017). The average end‐of‐winter SWE in both watersheds indicates a positive trend. Comparison of SWE records with cumulative solid precipitation measured at the Imnaviat [sic] SNOTEL site highlights the undercatch of gauge precipitation and difference in long‐term trends. In this paper, we present a historic overview of data collection, discuss data accuracy, and point out advantages and limitations associated with ground‐based snow measurements in remote Arctic locations. As new methods and techniques of measuring SWE and solid precipitation become available, the presented data set will provide a historic perspective for new observations and will quantitatively relate current or future snow conditions to those that have occurred since the late twentieth century.
The circFASN/miR-33a pathway participates in tacrolimus-induced dysregulation of hepatic triglyceride homeostasis
Authors: Zhang Chenzhi , Chen Kangchen , Wei Rongli , Fan Guanghan , Cai Xuechun , Xu Li , Cen Beini , Wang Jianguo , Xie Haiyang , Zheng Shusen , Xu Xiao 
Published: March 2020

AbstractDyslipidemia exhibits a high incidence after liver transplantation, in which tacrolimus, a widely used immunosuppressant, plays a fundamental role. MicroRNAs and related circRNAs represent a class of noncoding RNAs that have been recognized as important regulators of genes associated with lipid metabolism. However, their transcriptional activities and functional mechanisms in tacrolimus-related dyslipidemia remain unclear. In this study, we observed that tacrolimus could induce triglyceride accumulation in hepatocytes by stimulating sterol response element-binding proteins (SREBPs) and miR-33a. Our in silico and experimental analyses identified miR-33a as a direct target of circFASN. Tacrolimus could downregulate circFASN and result in elevated miR-33a in vivo and in vitro. Overexpression of circFASN or silencing of miR-33a decreased the promoting effects of tacrolimus on triglyceride accumulation. Clinically, the incidence of dyslipidemia in liver transplant recipients with elevated serum miR-33a after liver transplantation was higher than that in patients without elevated serum miR-33a (46.3% vs. 18.8% p = 0.012, n = 73). Our results showed that the circFASN/miR-33a regulatory system plays a distinct role in tacrolimus-induced disruption of lipid homeostasis. MiR-33a is likely a risk factor for tacrolimus-related dyslipidemia, providing a potential therapeutic target to combat tacrolimus-induced dyslipidemia after liver transplantation.
The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages
Authors: Zhang Dapeng , Shi Rongchen , Xiang Wei , Kang Xia , Tang Bo , Li Chuan , Gao Linfeng , Zhang Xuan , Zhang Lili , Dai Rongyang , Miao Hongming 
Published: March 2020

AbstractLipid metabolic reprogramming plays an essential role in regulating the progression of colorectal cancer (CRC). However, the effect of lysophosphatidic acid (LPA) metabolism on CRC development is incompletely characterized. Here, we compared the mRNA levels of human CRC tissues to those of paracarcinoma tissues and focused on the notably enriched LPA metabolic pathways. We identified and verified that 1-acylglycerol-3-phosphate O-acyltransferase 4 (Agpat4) was aberrantly expressed in CRC tissues and predicted poor survival in CRC patients. Manipulating Agpat4 expression in CRC cells did not affect the growth or migration of CRC cells in vitro, whereas Agpat4 silencing suppressed CRC cell growth in subcutaneous and peritoneal xenograft models. Mechanistically, Agpat4 silencing-induced LPA release from CRC cells and polarized macrophages to an M1-like phenotype through LPA receptors 1 and 3. This M1 activation, characterized by elevated p38/p65 signaling and increased proinflammatory cytokines, promoted the infiltration and activation of CD4+ and CD8+ T cells in the tumor microenvironment. Modulation of the Agpat4/LPA/p38/p65 axis regulated macrophage polarization, T-cell activity and CRC progression. Notably, combined therapy with LPA and regular chemotherapy drugs synergistically suppressed CRC development. Taken together, our results showed that the Agpat4/LPA axis in CRC cells regulated p38/p65 signaling-dependent macrophage polarization, T-cell activation, and CRC progression. The Agpat4/LPA/p38/p65 axis might represent a potential target for therapy in the clinic.
Targeted assemblies of cas1 suggest CRISPR-Cas’s response to soil warming
Authors: Wu Ruonan , Chai Benli , Cole James R , Gunturu Santosh K , Guo Xue , Tian Renmao , Gu Ji-Dong , Zhou Jizhong , Tiedje James M 
Published: March 2020

Abstract
There is an increasing interest in the clustered regularly interspaced short palindromic repeats CRISPR-associated protein (CRISPR-Cas) system to reveal potential virus–host dynamics. The universal and most conserved Cas protein, cas1 is an ideal marker to elucidate CRISPR-Cas ecology. We constructed eight Hidden Markov Models (HMMs) and assembled cas1 directly from metagenomes by a targeted-gene assembler, Xander, to improve detection capacity and resolve the diverse CRISPR-Cas systems. The eight HMMs were first validated by recovering all 17 cas1 subtypes from the simulated metagenome generated from 91 prokaryotic genomes across 11 phyla. We challenged the targeted method with 48 metagenomes from a tallgrass prairie in Central Oklahoma recovering 3394 cas1. Among those, 88 were near full length, 5 times more than in de-novo assemblies from the Oklahoma metagenomes. To validate the host assignment by cas1, the targeted-assembled cas1 was mapped to the de-novo assembled contigs. All the phylum assignments of those mapped contigs were assigned independent of CRISPR-Cas genes on the same contigs and consistent with the host taxonomies predicted by the mapped cas1. We then investigated whether 8 years of soil warming altered cas1 prevalence within the communities. A shift in microbial abundances was observed during the year with the biggest temperature differential (mean 4.16 °C above ambient). cas1 prevalence increased and even in the phyla with decreased microbial abundances over the next 3 years, suggesting increasing virus–host interactions in response to soil warming. This targeted method provides an alternative means to effectively mine cas1 from metagenomes and uncover the host communities.
Magnetic–acoustic biphysical invisible coats for underwater objects
Authors: Zhou Yi , Chen Jian , Liu Liu , Fan Zheng , Ma Yungui 
Published: March 2020

AbstractMagnetic fields and acoustic waves are the two fundamental measures to perceive underwater objects, which, however, have never been simultaneously handled before. In this work, we propose and demonstrate a biphysical submillimeter-thick metamaterial coat that can simultaneously make underwater objects invisible to both magnetic fields and acoustic waves. The conformal coat is a subtle integration of an open-cavity acoustic absorber made of a dissipative acoustic metasurface (AMS) and a bilayer magnetic cloak. Experimentally, a magnetic cloaking effect with a field disturbance ratio of <0.5% is obtained over a broad-frequency range (10–250 kHz), and the compound metamaterial coat can strongly attenuate ultrasonic waves with a near-unity absorptivity. The magnetic subcoat can be freely combined with various AMS layers to achieve a wideband acoustic stealth effect for different spectral regimes. This work may open up a new way to build multifunctional devices for various waterborne applications.
Imaging grain microstructure in a model ceramic energy material with optically generated coherent acoustic phonons
Authors: Wang Yuzhou , Hurley David H. , Hua Zilong , Pezeril Thomas , Raetz Samuel , Gusev Vitalyi E. , Tournat Vincent , Khafizov Marat 
Published: March 2020

AbstractCharacterization of microstructure, chemistry and function of energy materials remains a challenge for instrumentation science. This active area of research is making considerable strides with methodologies that employ bright X-rays, electron microscopy, and optical spectroscopy. However, further development of instruments capable of multimodal measurements, is necessary to reveal complex microstructure evolution in realistic environments. In this regard, laser-based instruments have a unique advantage as multiple methodologies are easily combined into a single instrument. A pump-probe method that uses optically generated acoustic phonons is expanding standard optical characterization by providing depth resolved information. Here we report on an extension of this method to image grain microstructure in ceria. Rich information regarding the orientation of individual crystallites is obtained by noting how the polarization of the probe beam influences the detected signal amplitude. When paired with other optical microscopies, this methodology will provide new perspectives for characterization of ceramic materials.
Modulation of BIN2 kinase activity by HY5 controls hypocotyl elongation in the light
Authors: Li Jian , Terzaghi William , Gong Yanyan , Li Congran , Ling Jun-Jie , Fan Yangyang , Qin Nanxun , Gong Xinqi , Zhu Danmeng , Deng Xing Wang 
Published: March 2020

AbstractELONGATED HYPOCOTYL 5 (HY5), a basic domain/leucine zipper (bZIP) transcription factor, acts as a master regulator of transcription to promote photomorphogenesis. At present, it’s unclear whether HY5 uses additional mechanisms to inhibit hypocotyl elongation. Here, we demonstrate that HY5 enhances the activity of GSK3-like kinase BRASSINOSTEROID-INSENSITIVE 2 (BIN2), a key repressor of brassinosteroid signaling, to repress hypocotyl elongation. We show that HY5 physically interacts with and genetically acts through BIN2 to inhibit hypocotyl elongation. The interaction of HY5 with BIN2 enhances its kinase activity possibly by the promotion of BIN2 Tyr200 autophosphorylation, and subsequently represses the accumulation of the transcription factor BRASSINAZOLE-RESISTANT 1 (BZR1). Leu137 of HY5 is found to be important for the HY5-BIN2 interaction and HY5-mediated regulation of BIN2 activity, without affecting the transcriptional activity of HY5. HY5 levels increase with light intensity, which gradually enhances BIN2 activity. Thus, our work reveals an additional way in which HY5 promotes photomorphogenesis, and provides an insight into the regulation of GSK3 activity.