bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving instructional practice through peer observation and feedback: A review of the literature
Authors: Ridge Brady L. , Lavigne Alyson L. 
Published: April 2020

The Every Student Succeeds Act provides an opportunity for policymakers and researchers to revisit what is known about effective teacher evaluation practices to make better-informed decisions moving forward. Principals—responsible for implementing new teacher evaluation reforms and accommodating the demands to spend more time observing and providing feedback to teachers—are overworked. They have little time to provide high-quality feedback, and may lack important content-based expertise. With these considerations in mind, we explore the role of peer observation and feedback as a vehicle to move beyond high-stakes evaluation and re-center efforts on instructional improvement. Our systematic review of extant literature (n = 38 documents, 92% peer-reviewed empirical articles) indicates that peer observation and feedback is a promising practice for instructional improvement, but one that lacks sufficient evidence. Policy, thus, can encourage innovation and research around this practice so that peer observation and feedback models can be piloted and the most effective established, as well as strategies to tackle the biggest barriers schools, particularly U.S. schools face in implementing such a practice—time.
Teacher accountability, datafication and evaluation: A case for reimagining schooling
Authors: Holloway Jessica 
Published: April 2020

The purpose of this commentary is to push the boundaries (real and perceived) of how we think about teacher accountability, education and the purpose of schooling in contemporary times. It takes as a starting point a view that recent changes to the Every Student Succeeds Act does little to shift the underpinning logics of high-stakes teacher accountability that ultimately threaten the stability and adaptability of public schools. Building from this presumption, it explores more universal features of contemporary schooling practices (e.g., standardization, datafication and evaluation) that undermine teacher expertise, autonomy and professional discretion. The purpose is to provide a new lens for thinking about the role of education and to radically disrupt the ‘norms’ we have come to accept as necessary features of modern schooling. Ultimately, it serves as a thought experiment to provide some space for imagining new possibilities and thinking “outside of” the traditional accountability “box”.
DO SABER COMUM A EPISTEMOLOGIA, DOS SIGNIFICADOS CONSTITUTIVOS DA DOCÊNCIA E DAS MARCAS DA PROFESSORALIDADE: ESPELHO DE SI MESMO
Authors: Lima Francisco Renato , Silva Jovina Da 
Published: April 2020

Starting from an inspiration in the models of doing research that break with linear perspectives in the field of human and social sciences, this study aims to present an analysis of the teaching establishment trajectory and professoralidade brands produced in the school of experience, taking as object analysis of the 'mirror of himself' and at the same time, seeks to establish a relationship between the autobiographical research and training processes and construction of teacher identity. For the development of such a proposal, if embarked-the theoretical and methodological ways of autobiographical research, qualitative and dialogical character of Bakhtin approach (BAKHTIN, 2011), together with the theoretical basis mainly proposed by Behrens (2013), Day (2001) Dominicé (1990), Freire (1996), Foucault (1996/2009), Novoa (2000/2001), Santos (2010), Passeggi (2011), Pereira (2001/2008/2013), among others, that light construction and text of scripture, in which it sought to link the ideas, to make them consistent, pointing to the teaching and the construction of professoralidade the senses; and the subject and its historicity, as a writing itself counted on a path trodden paths that were ‘common knowledge epistemology’ (FREIRE, 1996). This theoretical articulation, combined with first-person accounts made by the author (perspective of Foucault's authorship), it can be concluded that this research approach challenges the teacher to be a researcher yourself and take ownership of a discourse that carries the
social dimension of his practice in the world. This subject, which proposes to take as a research object to his own life story - a
‘writing itself ’ - brings out in his speech, some clues that enable to identify as ‘being a teacher’ permeates the question of subjectivity
and how each subject throughout his life trajectory, though unpretentiously, it makes available to teach and learn in an interactive
and dialogical way with the world.
Wojnowo copy of philosophical works of John Damascene and Johann Spangenberg translated by Andrei Kurbskiy
Authors: Morozova Nadezhda 
Published: April 2020

The Museum of Icons and Culture of Old Believers in the village of Wojnowo (Warmian-Masurian Voivodeship, Poland) contains a manuscript of the late 19th century containing translations of the philosophical works of John Damascene, Johann Spangenberg and Pseudo-Justin Martyr, as well as two original texts by Andrei Kurbskiy. The investigation of the manuscript showed that the works of John Damascene and Spangenberg in this collection are presented in the translation of Kurbskiy-Obolenskiy. The aim of this work is to determine the structural and compositional features of the translation of the philosophical works of John Damascene and Spangenberg, made in the 1570s. in the circle of Andrei Kurbsky, and on the basis of the identified ones, to find potentially related copies, which could be an antigraph or a photograph of the manuscript from Wojnowo monastery. The study revealed four copies of the translations of Dialectic and Elementary Introduction into Dogmas by John Damascene (and Spangenberg’s Syllogisms), potentially related to Wojnowo codex. At least two of them contain structural and compositional features identical to Wojnowo copy of the Kurbskiy’s translation of Elementary Introduction into Dogmas.
Дешифрування видового складу лісових насаджень за даними сезонних мозаїк супутникових знімків Landsat і вибіркової інвентаризації лісів
Authors: Myroniuk Viktor 
Published: April 2020

Дешифрування видового складу лісових насаджень за супутниковими знімками має важливе значення для оцінювання стану та динаміки лісових ресурсів. Для цього в роботі використано часові ряди знімків Landsat 8 OLI, а як джерело опорної інформації – дані регіональної інвентаризації лісів Сумської області 2013 р., отримані на 333 кругових пробних ділянках. Супутникові знімки відібрано для часового періоду 2014-2016 рр. та скомпоновано в безхмарні мозаїки для трьох сезонів: квітень - жовтень, літо, осінь. Для дешифрування поширення деревостанів різного видового складу, а також деревних видів, які домінують у складі насаджень, на основі методу k найближчих сусідів (k-NN) спрогнозовано значення сум площ перерізів восьми найбільш представлених у лісовому фонді області видів. У дослідженні використано алгоритм k-NN методу, адаптований до платформи хмарних обчислень Google Earth Engine. Як міру пошуку найближчих сусідів застосовано Евклідову відстань у просторі спектральних показників супутникових знімків Landsat і допоміжної неспектральної інформації. За результатами досліджень отримано неперервні попіксельні оцінки сум площ перерізів деревостанів сосни, дуба, клена, липи, берези, ясена, осики та вільхи. На основі отриманих карт встановлено поширення основних лісотвірних деревних видів Сумської області, а за оцінками сум площ перерізів створено карту деревних видів, які домінують у насадженнях. На основі порівняння розподілу площі деревостанів за деревними видами, що домінують у насадженнях, встановлено узгодженість у відсотковому співвідношенні оцінок із офіційними даними обліку лісів області. На основі виконаних досліджень визначено актуальним запровадження в інвентаризацію лісів України методів дистанційного зондування Землі.
Економіко-правове регулювання охорони та збереження біорізноманіття екосистем: теорія і практика
Authors: Dubovich Ion , Vasylyshyn Khrystyna , Fomicheva Tatyana , Volkovska Yuliia 
Published: April 2020

Серед основних проблем економіко-правового регулювання особливе місце займає охорона та збереження біорізноманіття екосистем. Доведено, що збіднення та зникнення біорізноманіття екосистем неминуче позначиться на якості життя і здоров’я населення.
Важливо звернути увагу на визначення терміну «біорізноманіття» у національних та міжнародно-правових актах. На цей час існує близько 85 визначень терміну «біорізноманіття» і, цей термін використовують уже понад п’ятдесят років. Проаналізовано основні причини та наслідки руйнування і втрати біорізноманіття екосистем в Україні та світі, як основного національного багатства кожної держави. Його збереження та невиснажливе використання розглядається як один із пріоритетів у сфері екологічної безпеки, а також охорони, використання та відтворення природних ресурсів.
У зв’язку з євроінтеграційними процесами в Україні та необхідністю адаптації нормативно-правових актів до міжнародних договорів, які Україна підписала та ратифікувала, проаналізовано міжнародні конвенції та угоди у сфері охорони і збереження біорізноманіття екосистем, подано практичні рекомендації щодо ефективного економіко-правового регулювання у сфері охорони та збереження екосистемного біорізноманіття. Запропоновано шляхи імплементації міжнародних конвенцій та угод у національне законодавство, прийняття Закону України «Про охорону та збереження біорізноманіття екосистем», проведення моніторингу біорізноманіття, здійснення монетизації екосистемних послуг, інтеграцію Конвенції про охорону біологічного різноманіття у Лісовий, Водний, Земельний, Податковий Кодекси України.
EMA Review of Daunorubicin and Cytarabine Encapsulated in Liposomes (Vyxeos, CPX-351) for the Treatment of Adults with Newly Diagnosed, Therapy-Related Acute Myeloid Leukemia or Acute Myeloid Leukemia with Myelodysplasia-Related Changes
Authors: Tzogani Kyriaki , Penttilä Karri , Lapveteläinen Tuomo , Hemmings Robert , Koenig Janet , Freire João , Márcia Silva , Cole Susan , Coppola Paola , Flores Beatriz , Barbachano Yolanda , Roige Silvia Domingo , Pignatti Francesco 
Published: April 2020

Abstract

On June 28, 2018, the Committee for Medicinal Products for Human Use adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Vyxeos, intended for the treatment of acute myeloid leukemia (AML). Vyxeos was designated as an orphan medicinal product on January 11, 2012. The applicant for this medicinal product was Jazz Pharmaceuticals Ireland Limited. Vyxeos is a liposomal formulation of a fixed combination of daunorubicin and cytarabine, antineoplastic agents that inhibit topoisomerase II activity and also cause DNA damage. The strength of Vyxeos is 5 units/mL, where 1 unit equals 1.0 mg cytarabine plus 0.44 mg daunorubicin. The marketing authorization holder Jazz Pharmaceuticals had found that this was an optimal ratio for the efficacy of the product. Study CLTR0310-301, a phase III, multicenter, randomized, trial of Vyxeos (daunorubicin-cytarabine) liposome injection versus standard 3+7 daunorubicin and cytarabine in patients aged 60–75 years with untreated high-risk (secondary) AML, showed a statistically significant difference between the two groups in overall survival (OS) with a median OS of 9.56 months in the daunorubicin-cytarabine arm compared with 5.95 months for standard chemotherapy (hazard ratio, 0.69; 95% confidence interval, 0.52–0.90; one-sided p = .003).
The most common side effects were hypersensitivity including rash, febrile neutropenia, edema, diarrhea/colitis, mucositis, fatigue, musculoskeletal pain, abdominal pain, decreased appetite, cough, headache, chills, arrhythmia, pyrexia, sleep disorders, and hypotension.

Implications for Practice
Vyxeos has demonstrated a clinically significant improvement in overall survival compared with the standard of care 7+3 in the proposed population of patients with newly diagnosed acute myeloid leukemia (AML) with myelodysplasia-related changes and therapy-related AML. This is remarkable given the very poor prognosis of these patients and their unmet medical need. Secondary endpoints support the primary outcome, in particular an increased rate of hematopoietic stem cell transplantation, which is potentially the only curative treatment in AML.
Non-antimicrobial effect of Alocasia denudata Engler against selected Gram-positive oral pathogen
Authors: Mohd Yusoff Nurul Akilah , Ismail Tuan Nadrah Naim Ismail , Shahidan Wan Nazatul Shima 
Published: April 2020

Introduction: Alocasia denudata is a herbal plant used by traditional healers as a wound healing agent and its potential as a healer has been proven scientifically. Normally, wounded tissue offers the opportunity for microflora to adhere, colonize, invade, and infect the surrounding healthy tissue. Therefore, the aim of this study is to assess the antimicrobial effect of A. denudata on selective oral pathogen as well as to analyze its phytochemical compound.
Methods: The stem of A. denudata was extracted with 80% ethanol solution, freeze-dried, and sent to poison center to analyze its phytochemical constituents. The bioassay applied for determining the antimicrobial effect employs the well agar diffusion method to the selected Gram-positive oral bacteria; Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, and non-oral pathogen Streptococcus pyogenes. These bacteria were incubated and the inhibition zone was recorded.
Results: Our results showed that the mean yield of extraction was 12.8% and that the different concentrations of A. denudata show no antimicrobial effects toward the selected Gram-positive oral pathogen including non-oral pathogen bacteria. However, the gas chromatography–mass spectrometry result showed that antimicrobial compound is present along with anti-inflammatory and antioxidant compounds but showed no effect on the oral pathogen.
Conclusion: A. denudata extract has antimicrobial compound but did not show antimicrobial activity toward the selected Gram-positive oral pathogen.
Recurrent squamous cell carcinoma of head and neck: results of treatment in the Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine in 2012–2016
Authors: Karabut R. Yu. , Vazhenin A. V. , Mozerova E. Y. , Sharabura T. M. , Sarycheva M. M. , Guz A. O. , Zakharov A. S. 
Published: April 2020

Introduction. There is no treatment for recurrence of head and neck squamous cell carcinoma, which significantly increases the overall survival (OS) of patients.The study objective is to analyze the results of treatment of patients with recurrences of squamous cell carcinoma of the head and neck and to assess the impact of risk factors for relapse, as well as different treatment options for relapse on OS. Materials and methods. In the period from 2012 to 2016, 182 patients with relapses of squamous cell carcinoma of the larynx, oral cavity and tongue received treatment in the Chelyabinsk regional clinical center of Oncology and nuclear medicine. The group 1 included 66 patients with resectable relapse who were operated. The group 2 consisted of 25 patients who received a course of radiation therapy. The group 3 consisted of 46 patients who underwent chemotherapeutic treatment of relapse. The group 4 was represented by combined treatment (surgery + radiation therapy), this group included 9 people. The group 5 consisted of those of patients who were not specifically treated for relapse because of the low Karnofsky index in patients (<70 %). Results. OS among patients who received special treatment was significantly higher compared with the group of symptomatic therapy. The median OS in the special treatment group was 40 months, and without it – 18 months. Comparing all types for treating relapse, the highest rates of OS were in the surgical treatment group. OS rates in combined therapy group and radiotherapy group were comparable rate in the radiotherapy. The lowest OS rate was after chemotherapy (only 21 months).Conclusion. Surgery is the optimal method for treating recurrent squamous cell carcinoma of head and neck, if it is resectable. If surgical treatment is not possible, no other method significantly increases the OS. If the overall status of the patient is normal, re-radiation or polychemotherapy may be performed. A limited category of patients can be subjected to combined treatment for relapse.
Total glossectomy in multimodal treatment of oropharyngeal cancer: immediate results
Authors: Sikorsky D. V. , Podvyaznikov S. O. , Kanishcheva N. V. , Kuligin M. V. , Skamnitsky D. V. 
Published: April 2020

The study objective is to analyze the results of combined antitumor therapy, which included glossectomy, to treat locally advanced and recurrent oropharyngeal squamous cell cancer.Materials and methods. We performed a retrospective analysis of multimodal antitumor therapy of 19 patients, who were treated in the Nizhny Novgorod Regional Clinical Oncologic Dispensary within 2009–2019. All patients underwent segmental resection of the mandible due to massive tumor invasion into the periosteum. After total glossectomy the defect was filled using pectoralis musculocutaneous flap. Due to the wide local tumor spread, a neck dissection (n = 7) or radical cervical lymphadenectomy (n = 12) were performed. During preventive surgery, metastases that were not detected before surgery were revealed in 2 patients in 1 neck lymph node. Results. Eleven patients had local purulent-necrotic postoperative complications. It was noted that after surgery but without radiation therapy complications developed in fewer patients (n = 4) and were less severe: of I degree – in 3 patients, of III degree – in 1 patient. Radiation therapy before surgery resulted in more severe purulent-necrotic complications in 7 patients: of I degree – in 2 patients, of II degree – in 1, of III degree – in 4. Mortality rates: 30-day, 60-day and 90-day – 10.5 %, 21 % and 37 %, respectively. The causes of death were complications of gastrostomy: profuse bleeding from the stomach wall (n = 1), acute psychosis complicated by cerebral edema (n = 1), increased heart failure (n = 1), necrosis of the anterior abdominal wall and cachexia, developed after gastrostomy (n = 1), continued tumor growth between chemotherapy courses (n = 3). Twelve patients survived more than 90 days after surgery, 3 patients – more than 2 years. As most of the patients could not swallow, they were administered a nasogastric tube, since a simultaneous gastrostomy increases the duration of a traumatic operation and aggravates the postoperative period.Conclusion. Multicomponent surgery after radiation therapy results in more often local purulent-necrotic postoperative complications than if the surgery is performed before radiation therapy. High mortality in the first 90 days after surgery (n = 7) due to local cancer spread is generally determined by the severe condition of patients with advanced cancer and the concomitant diseases. However, rejection of gastrostomy in favor of nasogastric tube seems reasonable, since several deaths in the early postoperative period may be occurred due to complications associated with gastrostomy.
Efficacy and tolerability of lenvatinib in patients with radioiodine-refractory differentiated thyroid cancer: results of a multicenter observational study in the Russian Federation
Authors: Borodavina E. V. , Isaev P. A. , Shurinov A. Yu. , Rumyantsev P. O. , Krylov V. V. , Petrosyan K. M. , Kaprin A. D. , Ivanov S. A. , Podvyaznikov S. O. , Romanov I. S. , Mudunov A. M. , Slashchuk K. Yu. , Zhikhorev R. S. , Volkonsky M. V. , Chagova R. M. , Suslova I. R. , Khryapa A. I. , Lepshokova A. Kh. , Fadeeva N. L. , Safarova A. R. , Kaleykina L. P. , Lymar E. V. , Chernyakova E. M. , Snezhko O. A. , Zinkovskaya A. E. , Mufazalov F. F. , Kuzmina E. S. , Druzhinina Yu. V. , Musin Sh. I. , Mukhitova M. R. , Khasanova A. I. , Safina S. Z. , Kirienko S. L. 
Published: April 2020

Background. The implementation of tyrosine kinase inhibitors into clinical practice improved treatment outcomes in patients with radioiodine-refractory differentiated thyroid cancer (RR-DTC). Lenvatinib is recommended as a first-line drug for these patients. The study objective is to analyze clinical experience with lenvatinib in patients with RR-DTC in the Russian Federation. Materials and methods. The data from 18 clinical sites in Russia was analyzed for the period December 2015 and September 2019. Seventyseven patients with histologically verified DTC, proven resistance to radioactive iodine therapy, and tumor progression (according to the Response Evaluation Criteria In Solid Tumors 1.1 criteria) were included in the study. Results.Median progression-free survival in patients included into analysis (n = 72) was 26.1 months. In patients who responded to therapy (including those with partial and complete response), median progression-free survival reached 36.2 months, which is higher than that reported in the updated results of the SELECT study (33.1 months). Lenvatinib-associated adverse events (AEs) were observed in 87 % of patients. Severe AEs were registered in 18.2 % of participants. In 6.5 % of cases, AEs lead to lenvatinib cessation; in 74 % of cases, AEs required dose reduction.Conclusion. Our findings suggest high efficacy and good tolerability of lenvatinib in patients with RR-DTC in routine clinical practice in the Russian Federation.
Sentinel lymph node biopsy for oral tongue squamous cell carcinoma cT1–2N0: prospective single-center study
Authors: Kotov M. A. , Radzhabova Z. A.‑G. , Novikov S. N. , Krzhivitsky P. I. , Ponomareva O. I. , Kostromina E. V. , Kushnarev V. А. , Radzhabova M. A. 
Published: April 2020

The study objectiveis to evaluate the informativeness of the biopsy technique of the signal lymph node (LN) in squamous cell carcinoma of the tongue cT1–2N0.Materials and methods.A prospective, single-center study included 26 patients with morphologically verified squamous cell carcinoma of the tongue cT1–2 and the lack of clinical and radiological data for metastatic damage to the LNs of the neck. All patients underwent a radioisotope study of the lymphatic flow from the primary tumor and the topography of the signal LNs. The informativeness of the biopsy of the signal LNs was evaluated in accordance with 2 diagnostic models. When using the first diagnostic model, all LNs accumulating colloids labeled with the 99mTc isotope were considered signal LNs. In the second model, only nodes accumulating radiocolloids and located in the immediate vicinity of the primary tumor of the tongue and / or connected with the primary tumor by the “pathway” of the lymphatic vessels were considered as signal LNs.Results.The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy, according to the 1st diagnostic model, were 66.6 % (95 % confidence interval (CI) 9.43–99.16), 100 % (95 % CI 85.18–100 %), 100 %, 95.83 % (95 % CI 82.28–99.13 %), 96.15 % (95 % CI 80.36–99.90 %), and when all LNs located along with the signal LNs were removed at the same levels as regional LNs, the sensitivity increased to 100 %. In the second model, the diagnostic values were: 33.3 % (95 % CI 0.84–90.57), 100 % (95 % CI 85.18– 100.00), 100 %, 92 % (95 % CI 83.78–96.24), 92.31 % (95 % CI 74.87–99.05 %).Conclusion.Evaluation of lymphatic outflow from the primary tumor and assessment of sentinel lymph node location in patients with stage cT1–2N0M0 squamous cell carcinoma of the tongue allow a doctor to determine the volume of lymph node dissection for each patient individually. Unilateral lymph node dissection is acceptable in patients with unilateral lymphatic outflow, whereas in patients with bilateral lymphatic outflow, it is associated with a quite high (up to 10 %) risk of metastatic lesions in the lymph nodes on the opposite side of the neck. It is necessary to excise all lymph nodes accumulating radiocontrast agent and regional lymph nodes located at the same levels.