bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association between Periodontitis and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis
Authors: Wijarnpreecha Karn , Panjawatanan Panadeekarn , Cheungpasitporn Wisit , Lukens Frank J , Harnois Denise M , Pungpapong Surakit , Ungprasert Patompong 
Published: June 2020

Background and Aims: Recent studies have suggested an association between periodontitis and nonalcoholic fatty liver disease (NAFLD) although the results were inconsistent. The current systematic review and meta- analysis was conducted with the aim to comprehensively investigate this possible association by identifying all relevant studies and combining their results together.
Methods: A comprehensive literature review was conducted utilizing the MEDLINE and EMBASE databases through December 2019 to identify all studies that compared the risk of NAFLD among patients with periodontitis to individuals without periodontitis. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird.
Results: A total of five studies with 27,703 participants fulfilled the eligibility criteria and were included in the meta-analysis. All five studies reported the magnitude of association between NAFLD and periodontitis that was diagnosed based on the periodontal pocket depth of > 3.5-4 mm. The pooled OR of unadjusted analysis was 1.48 (95%CI: 1.15-1.89; I 2 92%). However, when adjusted results from the primary studies were used, pooled OR decreased to 1.13 and lost its statistical significance (95%CI: 0.95–1.35; I 2 67%). Three studies reported the magnitude of association between NAFLD and periodontitis that was diagnosed based on a clinical attachment level of ≥ 3 mm. The pooled OR of unadjusted analysis was 1.13 (95%CI: 1.07-1.20; I 2 0%). However, when adjusted results from the primary studied were used, pooled OR decreased to 1.08 and lost its statistical significance (95%CI: 0.94–1.24; I 2 58%).
Conclusions: The study found a significant association between periodontitis and NAFLD. However, the association lost its significance when various metabolic parameters were adjusted, suggesting that those metabolic conditions, not periodontitis itself, were predisposing factors for NAFLD.
Clinical Characteristics and Risk Factors for Pneumocystis Jirovecii Pneumonia during Immunosuppressive Treatment in Patients with Ulcerative Colitis: A Retrospective Study
Authors: Kojima Kentaro , Sato Toshiyuki , Uchino Motoi , Yokoyama Yoko , Takagawa Tetsuya , Ohda Yoshio , Hida Nobuyuki , Watanabe Kenji , Hori Kazutoshi , Miwa Hiroto , Ikeuchi Hiroki , Nakamura Shiro , Shimizu Masahito 
Published: June 2020

Aims: This study aimed to clarify the clinical characteristics of Pneumocystis jirovecii pneumonia (PJP) infection in patients with ulcerative colitis (UC) and to identify risk factors for PJP using a retrospective case–control study.
Methods: Of 4,525 patients with UC treated between 2007 and 2019, we identified those who satisfied the criteria for PJP. The Lichtiger clinical activity index (LCI) was compared between the initiation of immunosuppressive drug treatment and the onset of PJP. A retrospective case–control study was conducted using a PJP group and a non-PJP group.
Results: Nine patients experienced PJP, of whom two died. Since October 2014, there were no cases of PJP among UC patients aged ≥50 years who were prescribed three or more immunosuppressive agents given prophylactic sulfamethoxazole-trimethoprim (TPM-SMX). The median LCI (range) was 13 (8–17) at the initiation of treatment versus 2 (1–8) at PJP onset (p = 0.016). The median time to PJP onset was 83 days after treatment initiation. In the PJP group the median age was significantly greater (p = 0.022), three immunosuppressants were used significantly more frequently (p = 0.004), and the lymphocyte counts during treatment were significantly lower (p < 0.01) than in the non-PJP group. The cut-off lymphocyte count that distinguished PJP patients from non-PJP patients was 570/μL according to a receiver-operating curve analysis.
Conclusions: Prophylactic administration of TPM-SMX prevented further cases of PJP. The onset of PJP occurred at the same time as the symptoms of UC were stabilizing and the immunosuppressive drugs were being reduced. Greater age, lower lymphocyte count, and treatment with three immunosuppressive drugs were risk factors for PJP.
COVID-19 e a Odontologia na prática atual
Authors: Santos Kátia Ferreira , Barbosa Marcelo 
Published: June 2020

Introdução: No final de 2019, em Hubei, localizado em Wuhan, China, surgiu o novo coronavírus, chamado 2019-nCoV, que causa síndrome respiratória aguda (SARS-CoV-2) e transmitido por inalação, ingestão e / ou contato direto das mucosas pela saliva. Os cirurgiões-dentistas foram identificados como os profissionais mais expostos ao risco de serem afetados pelo COVID-19, pois produzem partículas aerossolizadas em seu trabalho, capazes de contaminar o meio ambiente e as pessoas. Objetivo: Orientar os dentistas, para ações clínicas de urgência e emergência, medidas preventivas e recomendadas, a fim de reduzir o risco de infecção. Método: Pesquisa recente no banco de dados PubMed / MEDLINE, com as palavras-chave: “COVID-19 e Odontologia” e os critérios de inclusão foram: artigos em inglês, com versão on-line completa, gratuitamente e aqueles que ainda se encontram em vias de publicação. Resultados: foram encontrados 35 artigos relacionados ao tema, dos quais 13 preencheram os critérios de inclusão e foram selecionados. Conclusão: Práticas de biossegurança, mensuração da temperatura corporal e adaptação aos testes para COVID-19 podem ser práticas inseridas, no contexto odontológico, para auxiliar no combate à pandemia.
The Values and the Rules of Law
Authors: Kasprzak Sylwester 
Published: June 2020

Wartości i zasady prawa
Artykuł poświęcony jest zagadnieniu połączenia dwóch kwestii, tj. wartości i regulacji prawnych. Stawiamy problem, że przepis prawny niesie wartości, powinien z nich wyrastać, a przede wszystkim powinien je chronić. Regulacje prawne zabezpieczają wartości. Jeśli chodzi o system prawa kanonicznego, prawnik kanonista powinien wyinterpretować normę moralną z normy kanonicznej, która jest zawarta w przepisie Kodeksu Prawa Kanonicznego. Wartość odnosić się do rozumienia pewnego dobra dla jednostki lub społeczności, które są traktowane jako warte realizacji, zwłaszcza w życiu jednostek. Z drugiej strony „norma” odnosi się do sposobu i granic, w których uniwersalne wartości mogą być konkretnie realizowane. Wartości człowieka mają bezpośredni wpływ na jego życie i zachowanie w społeczeństwie. Artykuł skupia się na funkcji sumienia ze względu na fakt, że odnosi się do najwyższych wartości ukrytych w Absolucie. Sumienie jest głosem wewnętrznym, który krytykuje podejmowane działania i ocenia je jako dobre lub złe. Norma jest ważna, jeśli realizuje dobro jako wartość. Podstawową wartością jest wartość prawdy. Jeśli chcemy uświadomić sobie jakąkolwiek wartość, musimy najpierw zdać sobie sprawę, że jest ona rzeczywiście wartością. Być wartością oznacza być prawdziwą wartością. Postulatami realizacji wartości są: rozum ludzki – ukazywanie prawdy, dobra, piękna. Za wszystko odpowiada człowiek, strażnik i współtwórca realnego świata. Norma wymaga pola jej spełnienia: może je zapewnić tylko rzeczywistość, będąc przygotowana na przyjęcie wartości.
Forest deforestation in the Brazilian amazon states and its impacts on natural resources: construction of statistical-econometric panel model for 2000-2018
Authors: Carvalho André Cutrim , Carvalho David Ferreira , Aires Alana Paula de Araújo 
Published: June 2020

Economic growth and improving income distribution contribute to an increased demand for land and to expansion of livestock production. Thus, in order to analyze effects of economic growth and income distribution on natural resources, first it is necessary to distinguish dynamics of economic growth; and second, it is essential to know the form in which economic growth is taking place: whether through the extensive absorption of using factors of production; or whether through intense absorption with an increase in productivity of the factors of production due to technical innovations; and third, the fact that the economy grows in a finite ecosystem implies an increase in opportunity costs. The effect of deforestation ultimately affects economic productivity and also provokes other ecological and socioeconomic disruptions. The aim of this paper is to analyze the impact of deforestation on natural resources of the area known as Legal Amazon, during the period 2000-2018. For this, statistical-econometric instruments from panel modeling have been used. The central conclusion is that the main regressors associated with the rate of deforestation in the surveyed states continue to be the significant causes of this problem throughout the region. Thus, it is assumed that deforestation in the Amazon is, in fact, the main factor responsible for destruction of natural resources. However, it cannot be denied that extensive livestock production continues to be the main activity responsible for the significant increase in deforestation in the region.
ASEAN, INDONESIA DAN RUSIA TIMUR JAUH: PELUANG DAN DIVERSIFIKASI [ASEAN, INDONESIA AND RUSSIA FAR EAST: OPPORTUNITIES AND DIVERSIFICATION]
Authors: Arlan Adri 
Published: June 2020

<p><span>Indonesia-Russia relations started at the end of World War II. Early relations were poor but became close during the Sukarno period. The post-Soviet era ushered a new height of Russia’s political, diplomatic, and economic presence in Southeast Asia. After the dissolution of the United Soviet Socialist Republic (USSR), Russia has focused on a grand re-engineering project, an important component of institutional stability. Part of the re-structuring included ambitious actions to re-brand a powerful image of her position in Southeast Asia, and in Asia and the Pacific, in general. Scholars have argued that there is a lack of knowledge in terms of Russia’s relations with countries of Southeast Asia (ASEAN). This can be explained by Russia’s unfamiliarity over the region’s diversity and by her insecurity with the dominance of the United States and China, among others. Nevertheless, the Putin Government has shifted its lens towards the Southeast Asian region by establishing stronger ties in areas of security and defense, energy development, and trade and people-to-people exchanges. This paper employs an ‘ethic’ perspective analysis of the actions taken by Russia in these areas and suggests possible future actions to enhance collaboration and cooperation with Southeast Asian countries such as Indonesia.</span></p><p><strong>BAHASA INDONESIA ABSTRAK:</strong> Hubungan Indonesia-Rusia telah dimulai sejak berakhirnya Perang Dunia ke II. Kerja sama yang terjadi antara kedua negara terjalin cukup erat di era Presiden Sukarno. Pasca runtuhnya Uni Soviet terjadi perubahan dinamika dalam hubungan politik, diplomatik dan ekonomi Rusia di Asia Tenggara. Saat ini Rusia fokus dalam menata ulang <em>grand strategy</em> penguatan kestabilan institusi baik dalam maupun luar negeri. Dalam hal penataan ulang kebijakan strategi luar negeri, Rusia berupaya untuk menciptakan <em>image</em> baru di Asia Tenggara dan Pasifik. Secara umum, para ahli berargumen bahwa masih minimnya wawasan dalam konteks hubungan Rusia dan Asosiasi Negara di Asia Tenggara (ASEAN). Hal ini dijelaskan dengan minimnya peran Rusia dalam hal kerja sama dan insekuritas akibat dominasi Amerika Serikat dan Republik Rakyat Tiongkok yang sudah mengakar kuat di kawasan. Namun demikian, administrasi Putin mencoba meningkatkan perhatiannya ke ASEAN dengan meningkatkan ikatan kerja sama dalam sektor pertahanan dan keamanan, energi, perdagangan dan <em>people to people</em> <em>contact</em>. Tulisan ini mengulas pendekatan ‘etis<a href="#_msocom_1">[</a>’ berupa pola kebijakan kerja sama yang diimplementasikan oleh Moskow serta rekomendasi diversifikasi kerja sama Rusia dengan negara di Asia Tenggara seperti Indonesia.</p>
THE FACTORS THAT INFLUENCE CONSUMER SATISFACTION ON GOPAY
Authors: Azmy Ahmad , Subakrie Pitrayadi , Azhari Muhammad Zakky 
Published: June 2020

This research aims to analyze the factors that influence consumer satisfaction on Go-Pay as a mobile payment application. The population of this research was all Gojek application users who use Go-Pay as mobile payment in South Jakarta. This research used primary data sourced from the questionnaire distributed to 150 respondents. Data were analyzed using multiple linear regression analysis. The results showed that four independent variables, i.e., price, trust, lifestyle, and benefit have a significant influence on consumer satisfaction of Go-Pay application. However, convenience has no significant influence on consumer satisfaction of Go-Pay.
Keywords: consumer satisfaction, Go-pay, lifestyle
PENILAIAN TINGKAT KESEHATAN KEUANGAN PT POS INDONESIA (PERSERO) PERIODE 2016-2018
Authors: Somadi Somadi 
Published: June 2020

This study aims to analyze the development of health assessment indicators and the financial health condition of PT Pos Indonesia (Persero). This research used a quantitative approach. The analysis technique used for evaluating the level of financial health referred to the Decree of The Minister of State-Owned Enterprises No. Kep-100/MBU/2002. The data collection technique used was documentation studies sourced from the annual report of PT Pos Indonesia (Persero) from 2016 through 2018. The results showed that the development of the indicator value of return on equity, return on investment, and cash ratio decreased, while the value of collection periods, the ratio of equity to total assets, and inventory turn over increased. This study also found the fluctuated value of the current ratio and total asset turnover. The financial health assessment in 2016 and 2017 had a healthy predicate. However, in 2018, it had an unhealthy financial health assessment predicate. Therefore, the company needs to have better financial performance to achieve good financial health conditions that will finally affect all stakeholders.
Keywords: financial health assessment, financial health development, financial performance, financial health predicate
Les mycotoxines dans les aliments des ruminants, leur devenir et leurs effets chez l’animal
Authors: YIANNIKOURIS A. , JOUANY J.P. 
Published: June 2020

Les mycotoxines sont des métabolites secondaires sécrétés par des moisissures appartenant principalement aux genres Aspergillus, Penicillium et Fusarium. Elles sont produites sur une large variété de denrées alimentaires avant, pendant et après récolte. En raison de la diversité de leurs effets toxiques et de leurs propriétés synergiques, les mycotoxines présentent un risque pour le consommateur d’aliments contaminés. Le métabolisme des mycotoxines est complexe et comprend plusieurs voies de bioactivation et de détoxication régies par des mécanismes de biotransformation résultant de l’action d’enzymes de l’hôte et de la flore microbienne présente dans le tube digestif. Une partie des toxines ou de leurs métabolites peut se fixer dans les tissus biologiques ; la majorité est éliminée par voie urinaire, fécale et lactée. Des différences de sensibilité sont observées entre espèces animales. Chez les ruminants, la toxicité se manifeste généralement par des troubles chroniques légers et n’aboutit que rarement à la mort. Une diminution de l’ingestion et des performances zootechniques est généralement observée. Le problème de la présence éventuelle de résidus toxiques se pose pour les produits animaux destinés à la consommation humaine (lait, viande, abats).
La réduction des risques passe par un contrôle de la contamination fongique des végétaux résultant de la maîtrise des méthodes de culture, de récolte et de conservation, par des techniques d’élimination des toxines sur l’aliment contaminé, et par une réduction de leur biodisponibilité dans le tractus digestif des animaux par l’emploi d’adsorbants.
Les radicaux libres dans l’organisme des animaux d’élevage : conséquences sur la reproduction, la physiologie et la qualité de leurs produits
Authors: AUROUSSEAU B. 
Published: June 2020

Les phénomènes radicalaires sont omniprésents dans la vie des animaux domestiques. Les radicaux libres oxygénés en sont à l’origine : leur structure électronique déséquilibrée leur confère une grande réactivité sur les constituants tissulaires qui leur permet d’entrer en jeu dans le contrôle d’une grande variété de réactions d’oxydo-réduction indispensables à la vie et à la croissance. Ils sont formés de façon continue dans l’organisme sain, en particulier par fuite d’électrons à partir de la chaîne respiratoire et au cours de l’élimination des composés tissulaires peroxydés. Les stress de toutes natures augmentent leur flux, épuisent les réserves de l’organisme en composés protecteurs qui les capturent (en particulier les vitamines et le glutathion) et augmentent donc les besoins correspondants des animaux. Pour finir, ils peuvent conduire à l’altération des structures cellulaires. Les conséquences intéressent une grande variété de fonctions animales, de façon directe (immédiatement après une série de chocs) ou indirecte (affaiblissement à long terme de l’organisme). Les attaques radicalaires peuvent ainsi conduire à une diminution du pouvoir fécondant des spermatozoïdes, à une baisse de la fertilité des femelles, à des mortalités embryonnaires et à une baisse de la vitalité des nouveau-nés. Par ailleurs, elles peuvent ralentir la croissance des animaux et conduire à l’obtention de carcasses et de viandes de qualités inférieures au potentiel des animaux. Ces baisses de qualité sont caractérisées par une durée de conservation plus courte et par une diminution de la teneur des tissus en composés intéressants pour la santé de l’homme. Le plus grand soin doit donc être apporté à la conduite des animaux d’élevage, afin de respecter l’équilibre entre l’attaque et la défense de l’organisme des animaux domestiques.

Documents à télécharger
T Cell Metabolism in Cancer Immunotherapy
Authors: Aksoylar Halil-Ibrahim , Tijaro-Ovalle Natalia M. , Boussiotis Vassiliki A. , Patsoukis Nikolaos 
Published: June 2020

Abstract
Immune checkpoint therapies aiming to enhance T cell responses have revolutionized cancer immunotherapy. However, although a small fraction of patients develops durable anti-tumor responses, the majority of patients display only transient responses, underlying the need for finding auxiliary approaches. Tumor microenvironment poses a major metabolic barrier to efficient anti-tumor T cell activity. As it now well accepted that metabolism regulates T cell fate and function, harnessing metabolism may be a new strategy to potentiate T cell-based immunotherapies.
Juncturae Tendinum Transfer for Extensor Tendon Reconstruction
Authors: Dhal Anil , Prakash Saket , Kalra Pulkit 
Published: June 2020

Case:
A 9-year-old girl, with a history of crush injury to her right hand 2 years ago, presented with inability to extend her index finger. Exploration revealed segmental loss of extensor tendons to the index finger with a pre-existing scar in the route of tendon transfer. The juncturae tendinum (JT) between extensor digitorum communis of the middle and ring fingers (Von Schroeder -3y) was transferred to reconstruct the extensor tendon. At 1-year follow-up, finger extension was restored, with improved grasp and release.

Conclusion:
JT transfer could prove useful in reconstructing zone II extensor tendon injuries with scarring and fibrosis in the route of conventional tendon transfer/graft.
The effect of anti-cancer and anti-tuberculosis treatments in lung cancer patients with active tuberculosis: a retrospective analysis
Authors: CHAI MEI , Shi Qingming 
Published: June 2020

Abstract
Background: Lung tuberculosis (TB) and lung cancer have a complex relationship. Data concerning TB treatment in lung cancer patients are still incomplete. The aim of this study was to investigate the effects of anti-cancer and anti-tuberculosis treatments in lung cancer patients with active lung TB. Methods: In a retrospective cohort study, lung cancer patients with active lung TB were identified between January 2013 and December 2016. Age- and sex-matched lung cancer patients without tuberculosis were selected as control subjects. Anti-cancer and anti-tuberculosis treatments were administered according to the national guidelines. The clinical courses and responses of lung cancer patients with and without active lung TB were examined and compared. Results: A total of 31 consecutive lung cancer patients were diagnosed with active lung TB. Fifty-one lung cancer patients without TB were enrolled as control subjects. Most patients in the two groups were elderly, had advanced non-small cell lung cancer and had tumor burdens. The anti-cancer treatment completion rate and response rate were not different between two group (87.1% in TB treatment patients vs. 92.2% in lung cancer patients; 77.4% in TB treatment patients vs. 88.2% in lung cancer patients, respectively). The anti-tuberculosis treatment completion rate and success rate was 87.1% and 80.7%. The median survival times were not different between two groups (52 weeks in TB treatment patients vs. 57 weeks in lung cancer patients). The change in Karnofsky performance score was also not different between two groups. The most common side effect in TB treatment patients was liver injury (61.3%). The most serious side effect in TB treatment patients was leukocyte deficiency (9.7% in Grade 3). Both of side effects mentioned above were not different between two groups. Conclusion: Both anti-cancer and anti-tuberculosis treatments can be safely and effectively administered in lung cancer patients with active lung TB. Attention should be paid to the risk of tuberculosis in lung cancer patients in TB high-burden countries. Keywords Lung cancer, tuberculosis, prognosis.
Anal incontinence and unrecognized anal sphincter injuries after vaginal delivery - A cross-sectional study in Norway
Authors: Berg Matilde Risopatron , Sahlin Ylva Ingrid 
Published: June 2020

Abstract

Background:Aim of the study was to estimate the prevalence of postpartum anal incontinence among women who delivered vaginally, and to assess the extent to which obstetric injuries to the anal sphincters are missed.Methods:All women (both primiparous and multiparous) who delivered vaginally and received any kind of sutures in the perineal area at Innlandet Hospital Trust Elverum in Norway between January 1, 2015 and June 30, 2016 were invited to answer a questionnaire on St. Mark’s incontinence score and to participate in a clinical examination of the pelvic floor including endoanal sonography.Results:In total 52,3% (n=207) of the 396 invited women participated in the study. Mean St. Mark’s score was 1.8 points (95% CI 1.4 to 2.1) at examination 14 months (mean) postpartum, and none of the participants suffered from weekly fecal leakage. Fecal urgency affected 11.7% (95% CI 7.1 to 16.3) of the participants, and 8.7% (95%CI 5.1 to 12.8) had weekly involuntary leakage of flatus. Nine women (9.3%, 95% CI 4.1 to 15.5) had a previously undetected third degree obstetric anal sphincter injury.Conclusion:The prevalence of anal incontinence among women who have delivered vaginally and received sutures due to 1stand 2nddegree perineal lacerations is low. Some obstetric anal sphincter injuries remain unrecognized at the time of delivery, but the symptoms of anal incontinence due to these injuries are in the lower half of the St. Mark’s incontinence score. Women with persistent symptoms like fecal urgency or leakage of gas and/or feces should be referred to evaluation by a colorectal surgeon in order to achieve optimal treatment.