bluuebunny/crossref_metadata_2025_split huggingface dataset:
TFEB is a master regulator of tumor-associated macrophages in breast cancer
Authors: Li Yong , Hodge Johnie , Liu Qing , Wang Junfeng , Wang Yuzhen , Evans Trent D , Altomare Diego , Yao Yongzhong , Murphy E Angela , Razani Babak , Fan Daping 
Published: June 2020

BackgroundTumor-associated macrophages (TAMs) play key roles in the development of many malignant solid tumors including breast cancer. They are educated in the tumor microenvironment (TME) to promote tumor growth, metastasis, and therapy resistance. However, the phenotype of TAMs is elusive and how to regulate them for therapeutic purpose remains unclear; therefore, TAM-targeting therapies have not yet achieved clinical success. The purposes of this study were to examine the role of transcription factor EB (TFEB) in regulating TAM gene expression and function and to determine if TFEB activation can halt breast tumor development.MethodsMicroarrays were used to analyze the gene expression profile of macrophages (MΦs) in the context of breast cancer and to examine the impact of TFEB overexpression. Cell culture studies were performed to define the mechanisms by which TFEB affects MΦ gene expression and function. Mouse studies were carried out to investigate the impact of MΦ TFEB deficiency or activation on breast tumor growth. Human cancer genome data were analyzed to reveal the prognostic value of TFEB and its regulated genes.ResultsTAM-mimic MΦs display a unique gene expression profile, including significant reduction in TFEB expression. TFEB overexpression favorably modulates TAM gene expression through multiple signaling pathways. Specifically, TFEB upregulates suppressor of cytokine signaling 3 (SOCS3) and peroxisome proliferator-activated receptor γ (PPARγ) expression and autophagy/lysosome activities, inhibits NLRP3 (NLR Family Pyrin Domain Containing 3) inflammasome and hypoxia-inducible factor (HIF)-1α mediated hypoxia response, and thereby suppresses an array of effector molecules in TAMs including arginase 1, interleukin (IL)-10, IL-1β, IL-6 and prostaglandin E2. MΦ-specific TFEB deficiency promotes, while activation of TFEB using the natural disaccharide trehalose halts, breast tumor development by modulating TAMs. Analysis of human patient genome database reveals that expression levels of TFEB, SOCS3 and PPARγ are positive prognostic markers, while HIF-1α is a negative prognostic marker of breast cancer.ConclusionsOur study identifies TFEB as a master regulator of TAMs in breast cancer. TFEB controls TAM gene expression and function through multiple autophagy/lysosome-dependent and independent pathways. Therefore, pharmacological activation of TFEB would be a promising therapeutic approach to improve the efficacy of existing treatment including immune therapies for breast cancer by favorably modulating TAM function and the TME.
TeV scale leptogenesis via dark sector scatterings
Authors: Borah Debasish , Dasgupta Arnab , Kang Sin Kyu 
Published: June 2020

AbstractWe propose a novel scenario of generating lepton asymmetry via annihilation and coannihilation of dark sector particles including t-channel processes. In order to realistically implement this idea, we consider the scotogenic model having three right handed neutrinos and a new scalar doublet, all of which are odd under an in-built $$Z_2$$Z2 symmetry. The lightest $$Z_2$$Z2 odd particle, if electromagnetically neutral, can be a dark matter candidate while annihilation and coannihilation between different $$Z_2$$Z2 odd particles into standard model leptons serve as the source of lepton asymmetry. The light neutrino masses arise at one loop level with $$Z_2$$Z2 odd fields going inside the loop. We show that experimental data related to light neutrinos, dark matter relic abundance and baryon asymmetry can be simultaneously satisfied in the model for two different cases: one with fermion dark matter and the other with scalar dark matter. In both scenarios, t-channel annihilation as well as coannihilation of $$Z_2$$Z2 odd particles play a non-trivial role in producing the non-zero CP asymmetry. Both the scenarios remain allowed from DM direct detection while keeping the scale of leptogenesis as low as TeV or less, lower than the one for vanilla leptogenesis scenario in scotogenic model along with the additional advantage of explaining the baryon-dark matter coincidence to some extent. Due to such low scale, the model is testable through rare decay experiments looking for charged lepton flavour violation.
ABCNet: an attention-based method for particle tagging
Authors: Mikuni V. , Canelli F. 
Published: June 2020

AbstractIn high energy physics, graph-based implementations have the advantage of treating the input data sets in a similar way as they are collected by collider experiments. To expand on this concept, we propose a graph neural network enhanced by attention mechanisms called ABCNet. To exemplify the advantages and flexibility of treating collider data as a point cloud, two physically motivated problems are investigated: quark–gluon discrimination and pileup reduction. The former is an event-by-event classification, while the latter requires each reconstructed particle to receive a classification score. For both tasks, ABCNet shows an improved performance compared to other algorithms available.
Investigation on low-frequency broadband characteristics of three-dimensional acoustic black hole superstructures
Authors: Zhou Zhuo , Liang Xiao , Wu Jiu Hui , Shang Peng , Niu Jiamin 
Published: June 2020

In order to solve the problem of strong penetration and difficult attenuation of low-frequency sound wave in traditional materials, several three-dimensional acoustic black hole superstructures are designed. First of all, multi-stage acoustic black holes are designed. It is found that their sound insulation coefficient is about 0.9 in the frequency range of 50–1600 Hz when the ration of the outlet tip diameter to the inlet diameter is [Formula: see text]. Then, the acoustic black hole thin and light superstructure was designed by embedding many acoustic black hole units in an array on the 10 mm thick plate. The sound insulation coefficient of two samples embedded 81 or 144 acoustic black holes is above 0.96 in the frequency range of 50–1600 Hz. To facilitate processing and engineering applications, we designed acoustic black hole wedge-shaped plate superstructures, and found that the average sound insulation of these acoustic black hole superstructures is 30 dB in the frequency range of 50–1600 Hz. These superstructures will be widely used in anechoic rooms, factories and aviation.
Analytical methods: Nonlinear longitudinal wave equation in a magnetoelectro-elastic circular rod, foam drainage and modified Degasperis–Procesi models arising in nonlinear water wave models
Authors: Seadawy Aly , Ali Asghar , Jhangeer Adil 
Published: June 2020

We form the analytical solitary wave solutions with the execution of generalized direct algebraic technique on three well-known nonlinear wave models, namely, called foam drainage, longitudinal magnetoelectro-elastic circular rod and modified Degasperis–Procesi equations. The derived solutions are hyperbolic functions in which some are plotted graphically on meticulous values to the parameters which provides the basic knowledge to understand physical significant of these three wave models. The obtained solutions show the efficiency and precision of our scheme. These derived new results prove that our novel technique is awfully effective and can be productive as a instrument solving for sundry other nonlinear evolution equations.
A Proposal to Improve the Early Diagnosis of Symptomatic Cancers in the United States
Authors: Sarma Elizabeth A. , Kobrin Sarah C. , Thompson Matthew J. 
Published: June 2020

Abstract
Many people are diagnosed with cancer after presenting with signs and symptoms of their disease to a healthcare provider. Research from developed countries suggests that, in addition to indicating later-stage disease, symptoms can also indicate earlier-stage disease, leading to investment in research and quality improvement efforts in the early detection of symptomatic cancers. This approach, labeled early diagnosis of symptomatic cancers, focuses on identifying cancer at the earliest possible stage in patients with potential signs and symptoms of cancer, and subsequently diagnosing and treating the cancer without delay. In the United States, early detection has focused on cancer screening, with relatively less research focused on early diagnosis of symptomatic cancers. In this commentary, we propose that research focused on early diagnosis of symptomatic cancers provides an important opportunity to achieve more earlier-stage cancer diagnoses in the United States. We highlight the potential of these efforts to improve cancer outcomes, and outline a research agenda to improve early diagnosis of symptomatic cancers in the United States focused on defining and describing pathways to cancer diagnosis, identifying signs and symptoms that can be used to promote early cancer detection, and developing interventions to improve early diagnosis of symptomatic cancers.
Revisiting classic ecogeographical rules, using a widely distributed mouse species (Apodemus draco)
Authors: Cui Jifa , Wang Bingxin , Ji Shengnan , Su Huawei , Zhou Youbing 
Published: June 2020

Abstract
Ecogeographical rules predict an association between specific adaptive morphological/physiological traits and latitude, elevation or cooler climates. Such ecogeographical effects are often expressed most clearly in widely distributed species due to continuous selective adaptation occurring over their geographic range. Based on 40 population sampling sites of 116 adult individuals (female, ; male, ) across an elevational range of 191–2573 m, we tested whether morphological traits accorded with predictions of Bergmann’s rule, Allen’s rule and Hesse’s rule for the South China field mouse (Apodemus draco). The effects of elevation on body size, appendage length and heart size were tested by fitting Linear Mixed-Effects Models. None conformed to Bergmann’s, Allen’s or Hesse’s rule. Clines in body size opposed Bergmann’s rule, and foot and snout length ratios opposed Allen’s rule. We conclude that South China field mice, a widely distributed species, exhibit an acute thermoregulation mechanism in which in colder conditions body sizes decrease – as opposed to altering heart sizes or surface area to volume ratios – requiring less energy to regulate body temperatures. Also, there was a stronger selective pressure to increase partial appendage lengths (i.e., foot and snout) to adapt to the specific environment (e.g. longer period of snow cover, up to 2573 m) rather than on a general shortening of appendages to cope with colder conditions.
Confessions of ‘the Weak’: The Ecclesiastical Hindrance of Determinism in Silence
Authors: McEntire Jeffrey L. 
Published: June 2020

Abstract
Christ imagery in Silence represents Endō’s intentional progression from ‘father-religion’ to ‘mother-religion’. This paper explicates the former as a distortive ideological belief—the determinism of the ‘strong’ and ‘weak’—that conveys Endō’s aversion for institutionalized and paternal aspects of Christianity; that sows feelings of superiority toward ‘the weak’ in Rodrigues (revealed especially as he administers confession); and that anthropomorphizes as an internal voice that accuses and haunts with fears of inadequacy. Christ’s immediacy through and sympathy for universal suffering relinquishes the categories of ‘strong’ and ‘weak,’ assures a doubting Rodrigues of forgiveness, and—along with the Christian-Buddhist foundation of Rodrigues’ self-renunciation—illustrates the interreligious nature of Endō’s mother-religion.
The Activation of the International Criminal Court’s Jurisdiction over the Crime of Aggression: International Institutional Law and Dispute Settlement Perspectives
Authors: Wong Meagan S. 
Published: June 2020

Abstract
In 2017, the plenary organ of the International Criminal Court (ICC), the Assembly of States Parties (ASP), adopted Resolution ICC-ASP/16/Res.5, deciding to activate the Court’s jurisdiction over the crime of aggression; and confirming an interpretation of the Rome Statute of the ICC (“Rome Statute”). While the characterization of this Resolution as either a subsequent agreement or subsequent practice under Articles 31(3) and 32 of the Vienna Convention on the Law of Treaties 1959 (“VCLT”) may be of relevance to treaty interpretation of the Rome Statute, this article submits that this Resolution is clearly a Rule of the International Organization, made by one of its organs. Resolution ICC-ASP/16/Res.5 may constitute a ‘relevant rule’ of interpretation with regard to the Rome Statute, thereby taking precedence over the general rules of interpretation in Articles 31 and 32 of the VCLT, particularly when the interpreter is an organ of the ICC. If a dispute arises with regard to the interpretation of the Rome Statute on the crime of aggression, two separate regimes at the ICC exist for the settlement of disputes depending on whether the dispute is one concerning the judicial functions of the Court. In the event that the dispute may be other than a ‘judicial function’, the ASP may be a mechanism for dispute settlement, along with other mechanisms of dispute settlement under international law.
The Chilling Effect of Indirect Expropriation Clauses on Host States’ Public Policies: a Call for a Legislative Response
Authors: Malakotipour Maryam 
Published: June 2020

Abstract
While International Investment Agreements (IIAs) can potentially contribute to host states’ development, the chilling effect of IIAs on host states’ public policies is the flip side of investment treaties. The lack of a clear statutory formulation of indirect expropriation and, hence, the interpretive loopholes in investor-state jurisprudence have caused unfavourable consequences attached to the application of IIAs on the protection and promotion of public welfare. This paper encourages states to revisit the formulation of their indirect expropriation clauses in line with the provided practical solutions, which allow states to have more policy space for their legitimate public policy actions without having their Foreign Direct Investment inflows decreased.
Strengthened Relationship between Tropical West Pacific and Midsummer Precipitation over Northeast China after the Mid-1990s
Authors: Han Tingting , Zhang Minghua , Zhou Botao , Hao Xin , Li Shangfeng 
Published: June 2020

AbstractThe relationship between the tropical west Pacific (TWP) and East Asian summer monsoon/precipitation has been documented in previous studies. However, the stability for the signals of midsummer precipitation in the TWP sea surface temperature (SST_TWP), which is important for climate variation, has drawn little attention. This study identifies a strengthened relationship between the leading empirical orthogonal function mode (EOF1) of midsummer precipitation over Northeast China (NEC) and the SST_TWP after the mid-1990s. The EOF1 mode shows a significant positive correlation with the SST_TWP for 1996–2016, whereas the relationship is statistically insignificant for 1961–90. Further results indicate that the North Pacific multidecadal oscillation (NPMO) shifts to a positive phase after the 1990s. In the positive NPMO phase, the anomalous circulation over the northeast Pacific expands westward over the central North Pacific–Aleutian Islands region. Concurrently, the SST_TWP-associated wavelike pattern propagates northeastward from the west Pacific to the northwest Pacific and farther to the North Pacific, facilitating the poleward expansion and intensification of the SST_TWP-related circulation anomalies over the North Pacific. Therefore, the SST_TWP has an enhanced influence on NEC precipitation through the modulation of the circulation anomalies over the central North Pacific–Aleutian Islands region after the mid-1990s. Additionally, the tropical anticyclone/cyclone associated with the SST_TWP expands westward to South China, exerting an intensified impact on meridional wind anomalies along eastern China and on moisture transport over NEC. These conditions jointly contribute to the strengthened relationship between the SST_TWP and the EOF1 mode of NEC midsummer precipitation after the mid-1990s.
Estimation of Wind Speed and Roughness Length Using Smartphones: Method and Quality Assessment
Authors: Hintz K. S. , Vedel H. , Kaas E. , Nielsen N. W. 
Published: June 2020

AbstractCrowdsourced data are now seen as a potential source of high-resolution observations in the atmospheric sciences. In this paper we investigate a potential data source, wind observations obtained using anemometers connected to handheld smartphones. The aim of this paper is twofold: to assess the quality of raw and height-extrapolated wind measurements from the handheld anemometer against professional-grade surface synoptic observation (SYNOP) stations, and to use these data of opportunity to infer a more accurate estimation of terrain roughness lengths. Roughness lengths are essential in numerical weather prediction; however, they are often poorly determined. Roughness lengths are also necessary when correcting near-surface wind observations for height offsets. For the analysis we performed a series of field experiments measuring wind profiles using handheld anemometers at roughly 2 m above ground. These raw measurements were then extrapolated to 10-m height using roughness lengths from three different sources. The extrapolation enabled us to compare the quality of roughness lengths estimated from smartphone measurements with those from traditional sources, as well as to assess the quality of these wind measurements against the professional-grade stations. We find that the handheld wind measurements are comparable in quality to wind measurements from SYNOP stations at 10-m height and that for some cases the handheld measurements can be more representative than SYNOP stations only about a kilometer away. To determine the roughness lengths, we examine a method that is based on the turbulent intensity derived from the high-frequency signal of the smartphone wind measurements. Under certain circumstances, the roughness lengths obtained with the approach presented here are superior to traditional sources.
Exploring Climate Change Threats to Beach Tourism Destinations: Application of the Hazard–Activity Pairs Methodology to South Africa
Authors: Friedrich Jonathan , Stahl Jannik , Hoogendoorn Gijsbert , Fitchett Jennifer M. 
Published: June 2020

AbstractClimate change poses significant threats to the sustainability of tourism economies globally. This is particularly true for beach tourism, which is highly dependent on the mean climate, daily weather, and natural setting of a destination to attract and satisfy tourists. This case study of the South African coastline provides new insights to the applicability of the vulnerability assessment methodology of hazard–activity pairs to the global south and specifically to sub-Saharan Africa. Through this method, tourists’ climate perceptions were analyzed and related to potential future impacts of climate change, creating hazard–activity pairs. Tourists’ perceptions of climate were captured by means of a questionnaire. Downscaled CMIP5 climate projections (RCP4.5 and RCP8.5) for six weather stations close to major beach tourism destinations were used to estimate changes in precipitation and temperature. This study reveals that future projections of a mean reduction in precipitation and increasing temperature may have positive rather than negative direct effects on South African beach tourism destinations because what tourists perceive as “comfortable” weather conditions are increasing in prevalence. Nevertheless, indirect and induced effects of an already changing climate, defining further hazard–activity pairs, must be considered in vulnerability assessments. This work endorses the applicability of the hazard–activity pair methodology to South Africa and the global south at large.
Augmented Visual Feedback: Cure or Distraction?
Authors: Eisma Yke Bauke , Borst Clark , Paassen René van , Winter Joost de 
Published: June 2020

Objective The aim of the study was to investigate the effect of augmented feedback on participants’ workload, performance, and distribution of visual attention. Background An important question in human–machine interface design is whether the operator should be provided with direct solutions. We focused on the solution space diagram (SSD), a type of augmented feedback that shows directly whether two aircraft are on conflicting trajectories. Method One group of novices ( n = 13) completed conflict detection tasks with SSD, whereas a second group ( n = 11) performed the same tasks without SSD. Eye-tracking was used to measure visual attention distribution. Results The mean self-reported task difficulty was substantially lower for the SSD group compared to the No-SSD group. The SSD group had a better conflict detection rate than the No-SSD group, whereas false-positive rates were equivalent. High false-positive rates for some scenarios were attributed to participants who misunderstood the SSD. Compared to the No-SSD group, the SSD group spent a large proportion of their time looking at the SSD aircraft while looking less at other areas of interest. Conclusion Augmented feedback makes the task subjectively easier but has side effects related to visual tunneling and misunderstanding. Application Caution should be exercised when human operators are expected to reproduce task solutions that are provided by augmented visual feedback.
COVID-19 quarantine: Post-traumatic stress symptomatology among Lebanese citizens
Authors: Fawaz Mirna , Samaha Ali 
Published: June 2020

Background: In the light of the global spread of the novel Coronavirus known as COVID-19 and in the absence of an approved treatment and vaccination, Lebanon has taken national measures, among which was home quarantine of the general public in an attempt to flatten the epidemic curve and avoid flooding the health care system. Aim: This study aimed at evaluating the prevalence of post-traumatic stress symptomatology (PTSS) during the times of COVID-19 quarantine among Lebanese citizens. Method: This quantitative cross-sectional study recruited 950 civilians and is aimed at measuring the prevalence of PTSS among the Lebanese citizens at an interval of 2 weeks and 1 month of COVID-19 quarantine. Results: The results have shown that quarantine in Lebanon has started to give rise to Post-traumatic Stress Disorder symptomatology during the second week which was worsened in the fourth week of COVID-19 quarantine. Conclusion: COVID-19 quarantine has influenced the psychology of Lebanese citizens and might have persistent effects after the end of this phase which is recommended to be explored.