bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local Public Investment Drivers in Peru
Authors: Jimenez Alvaro , Merino Christian , Sosa Juan Carlos 
Published: October 2020

Around half of Peru’s public investment is made by local governments. Through the estimation of a dynamic panel data model for 1796 local governments between 2010 and 2018, we find that the most important drivers for local public investment are: (i) availability of funding sources, especially those associated to non-renewable natural resource revenues; (ii) variables associated with each local government’s capacity to plan, budget and execute public investment; and (iii) political budget cycle effects, especially during the year following local elections. Furthermore, we extend our analysis by differentiating between local governments with reelected and non-reelected authorities, and by grouping local governments according to their economic size. Most of our results are shown to be robust across different specifications. Results from this paper can be used as a starting point to design mechanisms that make public investment more stable and predictable in a context where reelection banning can further deepen public investment’s fall.
A MEDICINA PARANAENSE NA ALVORADA DO SÉCULO XX: uma análise das discussões veiculadas na Gazeta Médica do Paraná (1901-1904)
Authors: LARA JORGE TIBILLETTI DE 
Published: October 2020

No presente texto, analisam-se as discussões veiculadas no primeiro periódico médico paranaense, a Gazeta Médica do Paraná, no seu curto período de duração, entre 1901 e 1904. O objetivo do trabalho é entender como os médicos paranaenses ligados ao periódico interpretavam a ciência e a medicina do período, considerando a especificidade do lugar que ocupavam na produção do conhecimento médico-científico brasileiro, ao mesmo tempo em que compreendiam o periódico como ferramenta importante para a defesa de seus interesses socioprofissionais. Faz-se uma discussão sobre a especificidade da medicina e da ciência em perspectiva regional, refletindo sobre o debate centro-periferia, buscando demonstrar como a medicina longe dos grandes centros se apropriava ou não daquilo que circulava, nem sempre permanecendo alheia a esse conhecimento, tampouco o incorporando totalmente.
Palavras-chave: Medicina. Periódico Médico. Paraná. Século XX.
ASSISTÊNCIA PÚBLICA NO RIO GRANDE DO SUL DA PRIMEIRA REPÚBLICA
Authors: ROSSI DAIANE SILVEIRA 
Published: October 2020

O presente artigo busca dialogar com a atual historiografia que versa sobre a assistência, tendo como escopo principal a conceituação da pobreza por meio de um estudo de caso de sobre o Serviço de Assistência Pública no Rio Grande do Sul, durante as primeiras décadas do século XX, em especial, na cidade de Santa Maria/RS. As fontes analisadas referem-se a publicações da época, cujo objetivo era explicar como deveria ser praticada a assistência no estado e no município.
Palavras-chave: Assistência. Pobreza. Rio Grande do Sul. Primeira República.
NILAI TAMBAH PENGOLAHAN UBI KAYU (Manihot esculenta Crantz) MENJADI KELANTING SEBAGAI SNACK LOKAL
Authors: Widiastuti Tri , Nurdjanah Siti , Utomo Tanto Pratondo 
Published: October 2020

Processing cassava into various food products is an effort to produce the economic added value of cassava. The processing also needed to reduce the damage of fresh cassava. This study was aimed to asses the performance of ‘kelanting’ as an indigenous snack and its added value. Data were collected at the Plamboyan Farmer Women's Small Group (KWT) in Rejomulyo Village, Palas Subdistrict, South Lampung Regency from August 2019 to November 2019 using questionnaire. The descriptive analysis used to describe the industry performance, while the added value calculated quantitatively using Hayami Table. The results showed that the performance of the processing of cassava by the Plamboyan Small Women Farmers Group (KWT) was affected by the high availability of raw materials, i.e. ‘mentega’ cassava as local variety and how to process ‘kelanting’. The added value of processing cassava become ‘kelanting’ was Rp 5,493.00/kg with a value-added ratio of 64.55% which was classified as high value-added (>40%). The profit was Rp. 3,743.00/kg with profit rate of 68.14%.
Keywords: added value, cassava, processed cassava product
FIGURAÇÕES DANTESCAS SOBRE A AMAZÔNIA
Authors: Macedo Miranda de Medeiros Olivia , Medeiros Euclides Antunes de 
Published: October 2020

Nesse artigo discutiremos alguns aspectos da estrutura poética e retórica da obra “Viagem Científica: pelo norte da Bahia, sudoeste de Pernambuco, sul do Piauí e de norte a sul de Goiás” (1916), escrita pelos médicos do Instituto Manguinhos, Artur Neiva e Belisário Pena. Referenciando nossa análise na concepção de história como narrativa e discurso ficcionalizado de Hayden White, buscamos compreender como as interpretações presentes nessa obra formularam paisagens de desolação e de tragicidade dantesca sobre o norte de Goiás, atualmente estado de Tocantins, a partir do primeiro quartel do século XX. As análises realizadas evidenciaram que os referidos médicos territorializaram os sertanejos goianos em uma rede de sentidos vinculada aos signos da doença, da pobreza e da inaptidão.
Allogeneic Platelet-Rich Plasma Versus Corticosteroid Injection for the Treatment of Rotator Cuff Disease
Authors: Jo Chris Hyunchul , Lee Seung Yeon , Yoon Kang Sup , Oh Sohee , Shin Sue 
Published: October 2020

Background:
The use of platelet-rich plasma (PRP) for the treatment of rotator cuff disease is still controversial. The purpose of the present study was to investigate the safety and efficacy of a fully characterized allogeneic pure PRP injection into the subacromial space of patients with rotator cuff disease in comparison with corticosteroid injection.

Methods:
A 2-group, parallel, assessor-blinded, randomized controlled trial was conducted. A total of 60 patients with clinically and structurally diagnosed rotator cuff disease were randomly assigned to receive a subacromial injection of either 4 mL of allogeneic pure PRP or a 4-mL mixture of 1 mL of 40-mg/mL triamcinolone acetonide and 3 mL of 2% lidocaine under ultrasonographic guidance. The primary outcomes were safety and the Constant score at 1 month. The secondary outcomes were pain, range of motion, muscle strength, functional scores, and overall satisfaction and function.

Results:
There were no treatment-related adverse events. The Constant score at 1 month did not significantly differ between the PRP and corticosteroid groups. At 6 months, the DASH (Disabilities of the Arm, Shoulder and Hand) score, overall function, and external rotation were significantly better in the PRP group than in the corticosteroid group, and the other clinical outcomes did not show significant differences. All pain measurements, the strength of the supraspinatus and infraspinatus, and 5 functional scores also improved slowly and steadily after injection, becoming significantly better at 6 months compared with those before the injection, whereas those in the corticosteroid group responded promptly but did not further improve.

Conclusions:
Allogeneic PRP injections for the treatment of rotator cuff disease are safe but are not definitely superior to corticosteroid injections with respect to pain relief and functional improvement during 6 months. The DASH score, overall function, and external rotation were significantly better in the PRP group than in the steroid group at 6 months. Generally, PRP slowly but steadily reduced pain and improved function of the shoulder until 6 months, whereas corticosteroid did not.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
The Persistence of Child and Adolescence Mental Healthcare: Results from Registry Data
Authors: Dijk Hermien , Freriks Roel , Alessie Rob , Mierau Jochen 
Published: October 2020

Abstract
Background: Previous studies on the persistence of child and adolescent mental healthcare do not consider the role of time-invariant individual characteristics. Estimating persistence of healthcare using standard linear models yields biased estimates due to unobserved heterogeneity and the autoregressive structure of the model. This study provides estimates of the persistence of child and adolescent mental healthcare taking these statistical issues into account.

Methods: We use registry data of more than 80,000 Dutch children and adolescents between 2000 and 2012 from the Psychiatric Case Registry Northern Netherlands (PCR-NN). In order to account for autocorrelation due to the presence of a lagged dependent variable and to distinguish between persistence caused by time-invariant individual characteristics and a direct care effect we use difference GMM-IV estimation. In further analyses we assess the robustness of our results to policy reforms, different definitions of care and diagnosis decomposition.

Results: All estimation results for the direct care effect (true state-dependence) show a positive coefficient smaller than unity with a main effect of 0.215 (p < 0.01), which indicates that the process is stable. Persistence of care is found to be 0.065 (p < 0.05) higher for females. Additionally, the majority of persistence of care appears to be associated with time-invariant characteristics. Further analyses indicate that (1) results are robust to different definitions of care and (2) persistence of care does not differ significantly across subgroups.

Conclusions: The results indicate that the majority of mental healthcare persistence for children and adolescents is due to time-invariant individuals characteristics. Additionally, we find that in the absence of further shocks a sudden increase of 10 care contacts in the present year is associated with an average of less than 3 additional care contacts at some point in the future. This result provides essential information about the necessity of budget increases for future years in the case of exogenous increases in healthcare use.
QTL mapping of winter dormancy and associated traits in two switchgrass pseudo-F1 populations: lowland x lowland and lowland x upland
Authors: Razar Rasyidah Mohamad , Missaoui Ali 
Published: October 2020

Abstract
Background Switchgrass (Panicum virgatum) undergoes winter dormancy by sensing photoperiod and temperature changes. It transitions to winter dormancy in early fall following at the end of reproduction and exits dormancy in the spring. The duration of the growing season affects the accumulation of biomass and yield. In this study, we conducted QTL mapping of winter dormancy measured by fall regrowth height (FRH) and normalized difference vegetation index (NDVI), spring emergence (SE), and flowering date (FD) in two bi-parental pseudo-F1 populations derived from crosses between the lowland AP13 with the lowland B6 (AB) with 285 progenies, and the lowland B6 with the upland VS16 (BV) with 227 progenies. Results We identified 18 QTLs for FRH, 18 QTLs for NDVI, 21 QTLs for SE, and 30 QTLs for FD. The percent variance explained by these QTLs ranged between 4.21 – 23.27% for FRH, 4.47 – 24.06% for NDVI, 4.35 – 32.77% for SE, and 4.61 – 29.74% for FD. A higher number of QTL was discovered in the BV population, suggesting more variants in the lowland x upland population contributing to the expression of seasonal dormancy underlying traits. We identified 9 regions of colocalized QTL with possible pleiotropic gene action. The positive correlation between FRH or NDVI with dry biomass weight suggests that winter dormancy duration could affect switchgrass biomass yield. The medium to high heritability levels of FRH (0.55 – 0.64 H2) and NDVI (0.30 – 0.61 H2) implies the possibility of using the traits for indirect selection for biomass yield. Conclusion Markers found within the significant QTL interval can serve as genomic resources for breeding non-dormant and semi-dormant switchgrass cultivars for the southern regions, where growers can benefit from the longer production season.
The local concentration of Ca2+ correlates with BMP7 expression and osseointegration in patients with total hip arthroplasty
Authors: Fu Xiaodong , Wang Weili , Li Xiaomiao , Gao Yingjian , Li Hao , Shen Yi 
Published: October 2020

Abstract
Background: A successful osseointegration of total hip arthroplasty (THA) relies on the interplay of implant surface and bone marrow microenvironment. This study was undertaken to investigate the impact of perioperative biochemical molecules (Ca2+, Mg2+, Zn2+, VD, PTH) on the bone marrow osteogenetic factors (BMP2, BMP7, Stro-1+ cells) in the metaphyseal region of the femoral head, and further on the bone mineral density (BMD) of Gruen R3. Methods: Bone marrow aspirates were obtained from the discarded metaphysis region of the femoral head in 51 patients with THA. Flow cytometry was used to measure the Stro-1+ expressing cells. ELISA was used to measure the concentrations of bone morphologic proteins (BMP2 and BMP7). The perioperative concentrations of the biochemical molecules above were measured by radioimmunoassay. The BMD of Gruen zone R3 was examined at 6 months after THA, using dual-energy X-ray absorptiometry (DEXA).Results: Our data demonstrated that the concentration of Ca2+ was positively correlated with BMP7 expression, and with the postoperative BMD of Gruen zone R3. However, the concentration of Mg2+ had little impact on the R3 BMD, although it was negatively correlated with the expression of BMP7. The data also suggested that the other biochemical molecules, such as Zn2+, VD, and PTH, were not significantly correlated with any bone marrow osteogenetic factors (BMP2, BMP7, Stro-1+ cells). The postoperative R3 BMD of patients of different gender and age had no significant difference.Conclusions: These results indicate the local concentration of Ca2+ may be an indicator for the prognosis of THA patients.
Effects of Prenatal Mindfulness-Based Childbirth Education on Child-Bearers’ Trajectories of Distress: A Randomized Control Trial
Authors: Sbrilli Marissa Danielle , Duncan Larissa G. , Laurent Heidemarie K. 
Published: October 2020

Abstract
Background. The perinatal period is a time of immense change, which can be a period of stress and vulnerability for mental health difficulties. Mindfulness-based interventions have shown promise for reducing distress, but further research is needed to identify long-term effects and moderators of mindfulness training in the perinatal period. Methods. The current study used data from a pilot randomized control trial (RCT) comparing a condensed mindfulness-based childbirth preparation program—the Mind in Labor (MIL)—to treatment as usual (TAU) to examine whether prenatal mindfulness training results in lower distress across the perinatal period, and whether the degree of benefit depends on child-bearers’ initial levels of risk (i.e., depression and anxiety symptoms) and protective (i.e., mindfulness) characteristics. Child-bearers (N=30) in their third trimester were randomized to MIL or TAU and completed assessments of distress—perceived stress, anxiety, and depressive symptoms—at pre-intervention, post-intervention, six-weeks post-birth, and one-year postpartum. Results. Multilevel modeling of distress trajectories revealed greater decreases from pre-intervention to 12 months postpartum for those in MIL compared to TAU, especially among child-bearers who were higher in anxiety and/or lower in dispositional mindfulness at baseline. Conclusions. The current study offers preliminary evidence for durable perinatal mental health benefits following a brief mindfulness-based program and suggests further investigation of these effects in larger samples is warranted.Trial registration: The ClinicalTrials.gov identifier for the study is: NCT02327559. The study was retrospectively registered on June 23, 2014. https://clinicaltrials.gov/ct2/show/NCT02327559
Socio-emotional and adaptive behaviour in children treated for severe anaemia at Lira Regional Referral Hospital, Uganda: a prospective cohort study.
Authors: Ssemata Andrew Sentoogo , Opoka Robert O. , Ssenkusu John M. , Nakasujja Noeline , John Chandy C. , Bangirana Paul 
Published: October 2020

Abstract
Background: Severe anaemia is a global public health challenge commonly associated with morbidity and mortality among children <5 years of age in Sub-Saharan Africa. However, less is known about the behavioural performance of children < 5 years surviving severe anaemia in low resource settings. We investigated social-emotional and adaptive behaviour in children < 5 years diagnosed with severe anaemia in Northern Uganda. Methods: We conducted a hospital based prospective cohort study among children 6 - 42 months who were treated for severe anaemia (n=171) at Lira Regional Referral Hospital, Uganda. Socio-emotional and adaptive behaviour were assessed 14 days post discharge using the Bayley Scales of Infant and Toddler Development, 3rd edition. Age-adjusted z-scores for each domain were calculated using scores from healthy community children (n=88) from the same environment for each age category. Multiple linear regression was used to compare z-scores in the social-emotional and adaptive behaviour scales between the two groups after adjusting for weight-for-age z-score, social economic status, mother’s education, father’s education and father’s employment on all the scales.Results: Compared with healthy community controls, children with severe anaemia had poorer [adjusted mean scores (standard error)], socio-emotional [-0.29, (0.05) vs. 0.01, (0.08), P=0.002]; but not overall/ composite adaptive behaviour [-0.10, (0.05) vs. -0.01, (0.07), P=0.343]. Within the adaptive behaviour subscales, children with SA displayed significantly poorer scores on the community use [adjusted mean score (standard error)], [-0.63, (0.10) vs. -0.01, (0.13), P<0.001]; and leisure [-0.35, (0.07) vs. -0.02, (0.07), P=0.036] skills. Conclusion: This study suggests that severe anaemia in children < 5 years is associated with poor social-emotional scores in the short-term post clinical recovery in Northern Uganda. We recommend long-term follow-up to determine the course of these problems and appropriate interventions to reduce the behavioural burden among children <5 years surviving severe anaemia in Uganda.
Defining malaria risks among forest workers in Aceh, Indonesia: A formative assessment
Authors: Ekawati Lenny Lia , Johnson Kelly C. , Jacobson Jerry O. , Cueto Carmen A. , Zarlinda Iska , Elyazar Iqbal RF , Fatah Abdul , Sumiwi Maria E. , Noviyanti Rintis , Cotter Chris , Smith Jennifer L. , Coutrier Farah N. , Bennett Adam 
Published: October 2020

Abstract
Background . Following a dramatic decline of malaria cases in Aceh province, geographically-based reactive case detection (RACD) was recently evaluated as a tool to improve surveillance with the goal of malaria elimination. While RACD detected few cases in households surrounding index cases, engaging in forest work was identified as a risk factor for malaria and infections from Plasmodium knowlesi —a non-human primate malaria parasite—were more common than expected. This qualitative formative assessment was conducted to improve understanding of malaria risk from forest work and identify strategies for targeted surveillance among forest workers. Methods. Between June and August, 2016, five focus groups and 18 in-depth interviews with forest workers and key informants were conducted in each of four subdistricts in Aceh Besar and Aceh Jaya districts. Themes included: types of forest activities, mobility of workers, interactions with non-human primates, malaria prevention and treatment-seeking behaviors, and willingness to participate in malaria surveys at forest work sites and using peer-referral. Results. Reported forest activities included mining, logging, and agriculture in the deep forest and along the forest fringe. Forest workers, particularly miners and loggers, described often spending weeks to months at work sites in makeshift housing, rarely utilizing mosquito prevention and, upon fever, self-medicating and seeking care from traditional healers or pharmacies rather than health facilities. Non-human primates are frequently observed near work sites, and most forest work locations are within a day’s journey of health clinics. Employers and workers expressed interest in undertaking malaria testing and in participating in survey recruitment by peer-referral and at work sites. Conclusions. Diverse groups of forest workers in Aceh are potentially exposed to malaria through forest work. Passive surveillance and household-based screening may under-estimate malaria burden due to extended stays in the forest and health-seeking behaviors. Active surveillance specifically targeting forest workers through work-site screening and/or peer-referral appears promising for addressing undetected infections.
Development and Validation of Nomograms for Predicting Overall Survival and Cancer-Specific Survival in Patients with Ovarian Clear Cell Carcinoma
Authors: Chen Qian , Wang Shu , Lang Jing-he 
Published: October 2020

Abstract
Background: Ovarian clear cell carcinoma (OCCC) is a rare histologic type of ovarian cancer. There is a lack of an efficient prognostic predictive tool for OCCC in clinical work. This study aimed to construct and validate nomograms for predicting the overall survival (OS) and cancer-specific survival (CSS) in patients with OCCC.Methods: Data of patients with primary diagnosed OCCC in the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2016 was extracted. Prognostic factors were evaluated with LASSO Cox regression and multivariate Cox regression analysis, which were applied to construct nomograms. The performance of the nomogram models was assessed by the concordance index (C-index), calibration plots, decision curve analysis (DCA) and risk subgroup classification. The Kaplan-Meier curves were plotted to compare survival outcomes between subgroups.Results: A total of 1541 patients from SEER registries were randomly divided into a training cohort (n=1079) and a validation cohort (n=462). Age, laterality, stage, lymph node (LN) dissected, organ metastasis and chemotherapy were independently and significantly associated with OS, while laterality, stage, LN dissected, organ metastasis and chemotherapy were independent risk factors for CSS. Nomograms were developed for the prediction of 3‐ and 5‐year OS and CSS. The C-indexes for OS and CSS were 0.802[95% confidence interval (CI) 0.773-0.831] and 0.802 (0.769-0.835), respectively, in the training cohort, while 0.746 (0.691-0.801) and 0.770 (0.721-0.819), respectively, in the validation cohort. Calibration plots illustrated favorable consistency between the nomogram predicted and actual survival. C-index and DCA curves also indicated better performance of nomogram than the AJCC staging system. Significant differences were observed in the survival curves of different risk subgroups.Conclusions: We have constructed predictive nomograms and a risk classification system to evaluate the OS and CSS of OCCC patients. They were validated to be of satisfactory predictive value, and could aid in future clinical practice.