bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biodiversity, systematics, and new taxa of cladid crinoids from the Ordovician Brechin Lagerstätte
Authors: Wright David F. , Cole Selina R. , Ausich William I. 
Published: November 2019

AbstractUpper Ordovician (Katian) strata of the Lake Simcoe region of Ontario record a spectacularly diverse and abundant echinoderm fauna known as the Brechin Lagerstätte. Despite recognition as the most taxonomically diverse Katian crinoid paleocommunity, the Brechin Lagerstätte has received relatively little taxonomic study since Frank Springer published his classic monograph on the “Kirkfield fauna” in 1911.Using a new collection of exceptionally preserved material, we evaluate all dicyclic inadunate crinoids occurring in the Brechin Lagerstätte, which is predominantly comprised of cladids (Eucladida and Flexibilia). We document 15 species across 11 genera, including descriptions of two new genera and four new species. New taxa include Konieckicrinus brechinensis n. gen. n. sp., K. josephi n. gen. n. sp., Simcoecrinus mahalaki n. gen. n. sp., and Dendrocrinus simcoensis n. sp.Although cladids are not commonly considered major components of the Early Paleozoic Crinoid Macroevolutionary Fauna, which is traditionally conceived as dominated by disparids and diplobathrid camerates, they are the most diverse major lineage of crinoids occurring in the Brechin Lagerstätte. This unexpected result highlights the important roles of specimen-based taxonomy and systematic revisions in the study of large-scale diversity patterns.UUID: http://zoobank.org/09dda7c2-f2c5-4411-93be-3587ab1652ab
Association of supplemental calcium and dairy milk intake with all-cause and cause-specific mortality in the UK Biobank: a prospective cohort study
Authors: Stasinopoulos L. C. , Zhou A. , Hyppönen E. 
Published: November 2019

AbstractExcessive Ca intakes have been proposed to associate with vascular calcification and a higher risk of prostate cancer. We investigated the associations of supplemental and dietary Ca intake with mortality using data from 497 828 UK Biobank participants. The average follow-up was 4·2 years and 14 255 participants died, 8297 from cancer, 2959 from CVD and 572 from respiratory disease. The use of Ca supplements and milk consumption were associated with differences in mortality in younger (≤65 years) but not in older participants (>65 years, Pinteraction ≤ 0·04 for all comparisons). Among participants <65 years, there was an inverse association between Ca supplementation (OR 0·91, 95 % CI 0·83, 0·99) and milk consumption (OR 0·93, 95 % CI 0·86, 1·00) with respect to all-cause mortality. In the same age group, milk drinkers had lower odds of cancer mortality (OR 0·89, 95 % CI 0·80, 0·98) but Ca supplement use was associated with increased odds of respiratory mortality (OR 1·69, 95 % CI 1·16, 2·74). All associations in participants aged ≥65 years were null after full adjustment. In sensitivity analyses stratified by hormone replacement therapy, Ca supplement use was associated with decreased odds of cancer mortality in users but increased risk in other women (OR 0·81, 95 % CI 0·69, 0·94 v. OR 1·17, 95 % CI 1·01, 1·35, respectively). To conclude, we saw little evidence for harm with dietary or supplemental Ca. Further studies are required to confirm the proposed interaction with hormone replacement therapy and to exclude reverse causation as a determinant in the association between Ca supplements and increased risk of respiratory diseases.
Post-moderate-intensity exercise energy replacement does not reduce subsequent appetite and energy intake in adolescents with obesity
Authors: Thivel D. , Roche J. , Miguet M. , Fillon A. , Khammassi M. , Beaulieu K. , Finlayson G. , Pereira B. , Miyashita M. , Thackray A. E. , Masurier J. , Duclos M. , Boirie Y. 
Published: November 2019

AbstractExercise modifies energy intake (EI) in adolescents with obesity, but whether this is mediated by the exercise-induced energy deficit remains unknown. The present study examined the effect of exercise with and without dietary replacement of the exercise energy expenditure on appetite, EI and food reward in adolescents with obesity. Fourteen 12–15-year-old adolescents with obesity (eight girls; Tanner 3–4; BMI 34·8 (sd 5·7) kg/m2; BMI z score 2·3 (sd 0·4)) randomly completed three experimental conditions: (i) rest control (CON); (ii) 30-min cycling (EX) and (iii) 30-min cycling with dietary energy replacement (EX + R). Ad libitum EI was assessed at lunch and dinner, and food reward (Leeds Food Preference Questionnaire) before and after lunch. Appetite was assessed at regular intervals. Lunch, evening and total EI (excluding the post-exercise snack in EX − R) were similar across conditions. Lunch and total EI including the post-exercise snack in EX + R were higher in EX − R than CON and EX; EX and CON were similar. Total relative EI was lower in EX (6284 (sd 2042) kJ) compared with CON (7167 (sd 2218) kJ; P < 0·05) and higher in EX + R (7736 (sd 2033) kJ) compared with CON (P < 0·001). Appetite and satiety quotients did not differ across conditions (P ≥ 0·10). Pre-meal explicit liking for fat was lower in EX compared with CON and EX + R (P = 0·05). There was time by condition interaction between EX and CON for explicit wanting and liking for fat (P = 0·01). Despite similar appetite and EI, adolescents with obesity do not adapt their post-exercise food intake to account for immediate dietary replacement of the exercise-induced energy deficit, favouring a short-term positive energy balance.
Significant genetic effects of JAK2 and DGAT1 mutations on milk fat content and mastitis resistance in Holsteins
Authors: Khan Muhammad Zahoor , Wang Di , Liu Lei , Usman Tahir , Wen Hui , Zhang Ruiqiang , Liu Shuli , Shi Liangyu , Mi Siyuan , Xiao Wei , Yu Ying 
Published: November 2019

AbstractImproving the production traits and resistance against mastitis in dairy cattle is a challenge for animal scientists across the globe. The present study was designed to investigate the genetic effects of single nucleotide polymorphisms (SNPs) in Janus kinase 2 (JAK2) and diacylglycerol acyltransferase (DGAT1) genes with production and mastitis-related traits. Four SNPs in JAK2 and one in DGAT1 were analyzed through Chinese Cow's SNPs Chip-I (CCSC-I) and genotyped in a population of 312 Chinese Holsteins. Our findings demonstrated that milk fat percentage, somatic cell count (SCC), somatic cell score (SCS), serum cytokines interleukin 6 (IL-6) and interferon gamma (IFN-γ) showed significant associations (P < 0.05) with at least one or more identified SNPs. Consequently, the analysis based on haplotypes amongst the SNPs in JAK2 revealed noteworthy (P < 0.05) association with SCC and IL-6. Collectively, our results verified the pleiotropic ability of detected SNPs in bovine JAK2 and DGAT1 for milk fat percentage as well as mastitis-related traits. The significant SNPs in both the genes could serve as powerful genetic markers to minimize mastitis risk. In addition, besides SCC and SCS, the IFN-γ and IL-6 could also be used as indicators of improved genetic resistance against mastitis.
The antidepressant standoff: why it continues and how to resolve it
Authors: Ormel Johan , Spinhoven Philip , de Vries Ymkje Anna , Cramer Angélique O. J. , Siegle Greg J. , Bockting Claudi L. H. , Hollon Steven D. 
Published: November 2019

AbstractBackgroundAntidepressant medications (ADMs) are widely used and long-term use is increasing. Given this extensive use and recommendation of ADMs in guidelines, one would expect ADMs to be universally considered effective. Surprisingly, that is not the case; fierce debate on their benefits and harms continues. This editorial seeks to understand why the controversy continues and how consensus can be achieved.Methods‘Position’ paper. Critical analysis and synthesis of relevant literature.ResultsAdvocates point at ADMs impressive effect size (number needed to treat, NNT = 6–8) in acute phase treatment and continuation/maintenance ADM treatment prevention relapse/recurrence in acute phase ADM responders (NNT = 3–4). Critics point at the limited clinically significant surplus value of ADMs relative to placebo and argue that effectiveness is overstated. We identified multiple factors that fuel the controversy: certainty of evidence is low to moderate; modest efficacy on top of strong placebo effects allows critics to focus on small net efficacy and advocates on large gross efficacy; ADM withdrawal symptoms masquerade as relapse/recurrence; lack of association between ADM treatment and long-term outcome in observational databases. Similar problems affect psychological treatments as well, but less so. We recommend four approaches to resolve the controversy: (1) placebo-controlled trials with relevant long-term outcome assessments, (2) inventive analyses of observational databases, (3) patient cohort studies including effect moderators to improve personalized treatment, and (4) psychological treatments as universal first-line treatment step.ConclusionsGiven the public health significance of depression and increased long-term ADM usage, new approaches are needed to resolve the controversy.
Trends in self-reported psychological distress among college and university students from 2010 to 2018
Authors: Knapstad Marit , Sivertsen Børge , Knudsen Ann Kristin , Smith Otto Robert Frans , Aarø Leif Edvard , Lønning Kari Jussie , Skogen Jens Christoffer 
Published: November 2019

AbstractBackgroundAn increase in reported psychological distress, particularly among adolescent girls, is observed across a range of countries. Whether a similar trend exists among students in higher education remains unknown. The aim of the current study was to describe trends in self-reported psychological distress among Norwegian college and university students from 2010 to 2018.MethodsWe employed data from the Students' Health and Wellbeing Study (SHoT), a nationwide survey for higher education in Norway including full-time students aged 18–34. Numbers of participants (participation rates) were n = 6065 (23%) in 2010, n = 13 663 (29%) in 2014 and n = 49 321 (31%) in 2018. Psychological distress was measured using the Hopkins Symptom Checklist-25 (HSCL-25).ResultsOverall, a statistically significant increase in self-reported psychological distress was observed over time across gender and age-groups. HSCL-25 scores were markedly higher for women than for men at all time-points. Effect-size of the mean change was also stronger for women (time-by-gender interaction: χ2 = 70.02, df = 2, p < 0.001): in women, mean HSCL-25 score increased from 1.62 in 2010 to 1.82 in 2018, yielding a mean change effect-size of 0.40. The corresponding change in men was from 1.42 in 2010 to 1.53 in 2018, giving an effect-size of 0.26.ConclusionsBoth the level and increase in self-reported psychological distress among Norwegian students in higher education are potentially worrying. Several mechanisms may contribute to the observed trend, including changes in response style and actual increase in distress. The relative low response rates in SHoT warrant caution when interpreting and generalising the findings.
Mateo and Juana: Racial Silencing, Epistemic Violence, and Counterarchives in Puerto Rican Labor History
Authors: Meléndez-Badillo Jorell A. 
Published: November 2019

AbstractDuring the first three decades of the twentieth century, a cluster of self-educated workers that called themselvesobreros ilustrados(enlightened workers) sought to dominate the means of knowledge production, reproduction, and documentation. The discourses produced by this group of working-class intellectuals did not challenge but complemented the elite's contempt towards the laboring masses. In order to be legible in the “Archive of Puertorriqueñidad”—an archive crossed by centuries of colonialism, slavery, and imperial violence—these ragged intellectuals created various layers of exclusions that silenced those individuals that unapologetically upheld their Blackness. These silencing practices not only had power in the moment in which they took place but also influenced later historical production. To explore these dynamics, this paper uses the stories of Juana Colón and Mateo Pérez Sanjurjo. Both were highly-respected Black illiterate labor organizers that were absent in the historical narratives obreros ilustrados wrote about the labor movement. Ultimately, this article seeks to create counterarchives by unearthing, imagining, and retelling the lives of those that were not deemed worthy of being represented in the historical record.
Small Spatial‐Scale Field‐Aligned Currents in the Plasma Sheet Boundary Layer Surveyed by Magnetosphere Multiscale Spacecraft
Authors: Chen Yuanqiang , Zhang Tielong , Wu Mingyu , Wang Guoqiang , Schmid Daniel , Baumjohann Wolfgang , Nakamura Rumi , Russell Christopher T. , Giles Barbara J. , Burch James L. 
Published: November 2019

AbstractField‐aligned currents play a significant role in the magnetosphere‐ionosphere coupling. With the multipoint measurements and the advanced instruments of the four Magnetosphere Multiscale spacecraft, we estimate the fine structure of field‐aligned currents in the plasma sheet boundary layer (PSBL) by using the plasma moment data from the Fast Plasma Investigation. Those fine field‐aligned currents under higher temporal resolutions could be quite different from that under the lower temporal resolution: Bipolar current signals can be observed under higher resolutions, while no current signal appears under the lower resolution; higher current density magnitude and shorter time scale of the current layer under higher resolutions are observed than that under the lower resolution. The essential reason could be that the spatial scale of some field‐aligned current layers in the PSBL is too small to be found by low temporal measurements; thus, our results demonstrate the necessity of high data resolutions in resolving the subproton‐scale structure of the field‐aligned current and dynamics in the PSBL.
Orogenic Recycling of Detrital Zircons Characterizes Age Distributions of North American Cordilleran Strata
Authors: Schwartz T.M. , Schwartz R.K. , Weislogel A.L. 
Published: November 2019

AbstractDetrital zircon (DZ) analysis has become the standard tool for source‐to‐sink sediment routing studies at many spatial and temporal scales. In North American source‐to‐sink studies, DZ distributions are commonly classified according to the presence/absence and proportions of DZ age groups associated with North American crustal provinces as well as peri‐Gondwanan and Cordilleran terranes. Although such a classification scheme is descriptive, these age groups typically do not uniquely identify most recent DZ source areas. Using a compilation of >19,000 individual DZ ages for Mesoproterozoic‐Paleogene strata of the northern Rocky Mountains, including 2,053 new analyses from the Paleogene Renova Formation and its equivalents in southwestern Montana, we demonstrate periodic derivation of first‐cycle DZ from crystalline sources and widespread recycling of poly‐cycle DZ from sedimentary sources over multimillion‐year timescales. Results show that (1) DZ age distributions become increasingly complex between Mesoproterozoic and Paleogene time with the introduction of new DZ sources to the study area, but (2) once an age group appears in the northern Rocky Mountains stratigraphy, grains of that age persist up‐section. These trends show that most DZ age groups are spatiotemporally ubiquitous and nonunique. We largely attribute this to periodic, tectonically induced recycling of DZ into progressively younger sedimentary systems, rather than prolonged derivation of DZ from crystalline basement sources, a trend that reflects the growth of increasingly complex topography associated with the North American Cordillera.
White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals
Authors: Koshiyama Daisuke , Fukunaga Masaki , Okada Naohiro , Morita Kentaro , Nemoto Kiyotaka , Usui Kaori , Yamamori Hidenaga , Yasuda Yuka , Fujimoto Michiko , Kudo Noriko , Azechi Hirotsugu , Watanabe Yoshiyuki , Hashimoto Naoki , Narita Hisashi , Kusumi Ichiro , Ohi Kazutaka , Shimada Takamitsu , Kataoka Yuzuru , Yamamoto Maeri , Ozaki Norio , Okada Go , Okamoto Yasumasa , Harada Kenichiro , Matsuo Koji , Yamasue Hidenori , Abe Osamu , Hashimoto Ryuichiro , Takahashi Tsutomu , Hori Tomoki , Nakataki Masahito , Onitsuka Toshiaki , Holleran Laurena , Jahanshad Neda , van Erp Theo G. M. , Turner Jessica , Donohoe Gary , Thompson Paul M. , Kasai Kiyoto , Hashimoto Ryota ,   COCORO
Published: November 2019

AbstractIdentifying both the commonalities and differences in brain structures among psychiatric disorders is important for understanding the pathophysiology. Recently, the ENIGMA-Schizophrenia DTI Working Group performed a large-scale meta-analysis and reported widespread white matter microstructural alterations in schizophrenia; however, no similar cross-disorder study has been carried out to date. Here, we conducted mega-analyses comparing white matter microstructural differences between healthy comparison subjects (HCS; N = 1506) and patients with schizophrenia (N = 696), bipolar disorder (N = 211), autism spectrum disorder (N = 126), or major depressive disorder (N = 398; total N = 2937 from 12 sites). In comparison with HCS, we found that schizophrenia, bipolar disorder, and autism spectrum disorder share similar white matter microstructural differences in the body of the corpus callosum; schizophrenia and bipolar disorder featured comparable changes in the limbic system, such as the fornix and cingulum. By comparison, alterations in tracts connecting neocortical areas, such as the uncinate fasciculus, were observed only in schizophrenia. No significant difference was found in major depressive disorder. In a direct comparison between schizophrenia and bipolar disorder, there were no significant differences. Significant differences between schizophrenia/bipolar disorder and major depressive disorder were found in the limbic system, which were similar to the differences in schizophrenia and bipolar disorder relative to HCS. While schizophrenia and bipolar disorder may have similar pathological characteristics, the biological characteristics of major depressive disorder may be close to those of HCS. Our findings provide insights into nosology and encourage further investigations of shared and unique pathophysiology of psychiatric disorders.
The functional variant of NTN1 contributes to the risk of nonsyndromic cleft lip with or without cleft palate
Authors: Li Dandan , Zhu Guirong , Lou Shu , Ma Lan , Zhang Chi , Pan Yongchu , Wang Lin 
Published: November 2019

AbstractPrevious genome-wide association study of nonsyndromic cleft lip with or without cleft palate (NSCL/P) identified a susceptible variant (rs4791774). We hypothesized that the functional single nucleotide polymorphism (SNP) may be in linkage disequilibrium with this lead SNP. The potential functional SNP (rs4791331) was identified by bioinformatic analysis. A case–control study with 891 orofacial cleft cases and 830 controls was designed to investigate its association with orofacial cleft. The allele-specific DNA-protein binding preference was predicted by JASPAR database. Cell proliferation, cycle and apoptosis, luciferase activity and netrin-1 (NTN1) expression were examined after transfection with the rs4791331 C/T vector in HEK-293 and HEPM cell lines. Forty-six lip tissues of NSCL/P patients were collected to detect NTN1 expression. ntn1a knockout zebrafish models were generated by CRISPR/Cas9 and observed with micro-CT. In the case–control study, the rs4791331-T allele was associated with an increased risk of nonsyndromic orofacial cleft (OR = 1.41, 95% CI = 1.19–1.68), as well as the subgroups cleft lip only (OR = 1.46, 95% CI = 1.14–1.87) and cleft lip and palate (OR = 1.58, 95% CI = 1.27–1.96). The T allele of rs4791331 exhibited anti-apoptotic effects and promoted cell cycle progression at the G1/S transition. Decreased enhancer activity and reduced NTN1 expression following transfection of the T allele were observed. Carriers of the CT/TT genotypes showed significantly lower expression of NTN1 than CC carriers. The ntn1a−/− zebrafish showed relatively wider intermaxillary fissures. These results indicate that rs4791331 (C > T) disrupted motif binding and led to abnormal expression of NTN1, which may be involved in the development of NSCL/P.
Long-range versus short-range effects in cold molecular ion-neutral collisions
Authors: Dörfler Alexander D. , Eberle Pascal , Koner Debasish , Tomza Michał , Meuwly Markus , Willitsch Stefan 
Published: November 2019

AbstractThe investigation of cold interactions between ions and neutrals has recently emerged as a new scientific frontier at the interface of physics and chemistry. Here, we report a study of charge-transfer (CT) collisions of Rb atoms with N$${}_{2}^{+}$$2+ and O$${}_{2}^{+}$$2+ ions in the mK regime using a dynamic ion-neutral hybrid trapping experiment. We observe markedly different CT kinetics and dynamics for the different systems and reaction channels studied. While the kinetics in some channels are consistent with classical capture theory, others show distinct non-universal dynamics. The experimental results are interpreted with the help of classical-capture, quasiclassical-trajectory and quantum-scattering calculations using ab-initio potentials for the highly excited molecular states involved. The theoretical analysis reveals an intricate interplay between short- and long-range effects in the different reaction channels which ultimately determines the CT dynamics and rates. Our results illustrate salient mechanisms that determine the efficiency of cold molecular CT reactions.
Southern Africa crustal anisotropy reveals coupled crust-mantle evolution for over 2 billion years
Authors: Thybo H. , Youssof M. , Artemieva I. M. 
Published: November 2019

AbstractThe long-term stability of Precambrian continental lithosphere depends on the rheology of the lithospheric mantle as well as the coupling between crust and mantle lithosphere, which may be inferred by seismic anisotropy. Anisotropy has never been detected in cratonic crust. Anisotropy in southern Africa, detected by the seismological SKS-splitting method, usually is attributed to the mantle due to asthenospheric flow or frozen-in features of the lithosphere. However, SKS-splitting cannot distinguish between anisotropy in the crust and the mantle. We observe strong seismic anisotropy in the crust of southern African cratons by Receiver Function analysis. Fast axes are uniform within tectonic units and parallel to SKS axes, orogenic strike in the Limpopo and Cape fold belts, and the strike of major dyke swarms. Parallel fast axes in the crust and mantle indicate coupled crust-mantle evolution for more than 2 billion years with implications for strong rheology of the lithosphere.