bluuebunny/crossref_metadata_2025_split huggingface dataset:
Theoretical study on the change of thermoelectric properties by substitution of group 4 elements in Fe2TiSn
Authors: Kim Chol-Jin , Jong Ju-Yong , Kim Jong-Hyok , Song Yong-Hyok , Ri Kum-Chol , Jong Yong-Son 
Published: October 2020

In this study, substitution effects of group 4 elements in Fe2TiSn thermoelectric material are studied by using density functional theory (DFT) and semi-classical Boltzmann transport theory. All of the substitution elements showed the most thermodynamic preference for the Sn site, and these substitutions for Fe2TiSn did not give much influence in the stability and mechanical property of Fe2TiSn. e2TiSn[Formula: see text]Pb[Formula: see text], and thermoelectric calculations showed the prominence of [Formula: see text]-type on [Formula: see text]-type dopingin these materials. The highest Seebeck coefficients of these compounds were −148, −228, −165 and −120 [Formula: see text]V/K for [Formula: see text]-type of Fe2TiSn, Fe2TiSn[Formula: see text]Si[Formula: see text], Fe2TiSn[Formula: see text]Ge[Formula: see text] and Fe2TiSn[Formula: see text]Pb[Formula: see text], respectively. The results showed that Si and Ge partial substitutions for Fe2TiSn could be the effective methods to enhance the thermoelectric property, and the maximum dimensionless figure of merit (ZT) at room temperature reached about 0.7 ([Formula: see text]cm[Formula: see text] [Formula: see text]-type doping concentration) in Fe2TiSn[Formula: see text]Si[Formula: see text] and 0.6 ([Formula: see text]cm[Formula: see text] [Formula: see text]-type doping concentration) in Fe2TiSn[Formula: see text]Ge[Formula: see text].
Soft Microenvironments Induce Chemoresistance by Increasing Autophagy Downstream of Integrin-Linked Kinase
Authors: Anlaş Alişya A. , Nelson Celeste M. 
Published: October 2020

Abstract

Breast cancer relapse can develop over the course of years as a result of dormant cancer cells that disseminate to secondary sites. These dormant cells are often resistant to conventional hormone and chemotherapy. Although recurrence is the main cause of death from cancer, microenvironmental factors that may influence resistance to therapy and duration of dormancy are largely unknown. Breast cancer relapse is often detected in tissues that are softer than the normal mammary gland or the primary breast tumor, such as bone marrow, brain, and lung. We therefore explored how stiffness of the microenvironment at secondary sites regulates tumor dormancy and the response of breast cancer cells to hormone and chemotherapy. In soft microenvironments reminiscent of metastatic sites, breast cancer cells were more resistant to the estrogen receptor modulator tamoxifen as a result of increased autophagy and decreased expression of estrogen receptor-α. Consistently, pharmacologic inhibition or genetic downregulation of autophagy increased the response of breast cancer cells to tamoxifen on soft substrata. In addition, autophagy was decreased downstream of integrin-linked kinase on stiff substrata. Altogether, our data show that tissue mechanics regulates therapeutic outcome and long-term survival of breast cancer cells by influencing autophagy.

Significance:
These findings characterize the persistence of dormant cells at metastatic sites, where soft microenvironments downregulate estrogen receptor expression and upregulate autophagy, thereby promoting therapy resistance in breast cancer cells.
Long-Term Outcome of the Randomized DAPA Trial
Authors: Haanschoten Danielle M. , Elvan Arif , Ramdat Misier Anand R. , Delnoy Peter Paul H.M. , Smit Jaap Jan J. , Adiyaman Ahmet , Demirel Fatma , Wellens Hein J.J. , Verheugt Freek W.A. , Ottervanger Jan Paul , Schalij M.J. , Zijlstra F. , Wever E.F.D. , de Boer M.J. , Boersma E. , Robbe H.W.J. 
Published: October 2020

Background:
The randomized DAPA trial (Defibrillator After Primary Angioplasty) aimed to evaluate the survival benefit of prophylactic implantable cardioverter defibrillator (ICD) implantation in early selected high-risk patients after primary percutaneous coronary intervention for ST-segment–elevation myocardial infarction.

Methods:
A randomized, multicenter, controlled trial compared ICD versus conventional medical therapy in high-risk patients with primary percutaneous coronary intervention, based on one of the following factors: left ventricular ejection fraction <30% within 4 days after ST-segment–elevation myocardial infarction, primary ventricular fibrillation, Killip class ≥2 or TIMI (Thrombolysis in Myocardial Infarction) flow <3 after percutaneous coronary intervention. ICD was implanted 30 to 60 days after MI. Primary end point was all-cause mortality at 3 years follow-up. The trial prematurely ended after inclusion of 266 patients (38% of the calculated sample size). Additional survival assessment was performed in February 2019 for the primary end point.

Results:
A total of 266 patients, 78.2% males, with a mean age of 60.8±11.3 years, were enrolled. One hundred thirty-one patients were randomized to the ICD arm and 135 patients to the control arm. All-cause mortality was significant lower in the ICD group (5% versus 13%, hazard ratio, 0.37 [95% CI, 0.15–0.95]) after 3 years follow-up. Appropriate ICD therapy occurred in 9 patients at 3 years follow-up (5 within the first 8 months after implantation). After a median long-term follow-up of 9 years (interquartile range, 3–11), total mortality (18% versus 38%; hazard ratio, 0.58 [95% CI, 0.37–0.91]), and cardiac mortality (hazard ratio, 0.52 [95% CI, 0.28–0.99]) was significant lower in the ICD group. Noncardiac death was not significantly different between groups. Left ventricular ejection fraction increased ≥10% in 46.5% of the patients during follow-up, and the extent of improvement was similar in both study groups.

Conclusions:
In this prematurely terminated and thus underpowered randomized trial, early prophylactic ICD implantation demonstrated lower total and cardiac mortality in patients with high-risk ST-segment–elevation myocardial infarction treated with primary percutaneous coronary intervention.

Registration:

URL:
https://www.trialregister.nl
; Unique identifier: Trial NL74 (NTR105).
Heterozygous Cystic Fibrosis Transmembrane Regulator Gene Missense Variants Are Associated With Worse Cardiac Function in Patients With Duchenne Muscular Dystrophy
Authors: Jiang Xuan , Shao Yanqiu , Araj Faris G. , Amin Alpesh A. , Greenberg Benjamin M. , Drazner Mark H. , Xing Chao , Mammen Pradeep P. A. 
Published: October 2020

Background
Duchenne muscular dystrophy (DMD) is a neuromuscular disorder caused by mutations within the dystrophin gene. DMD is characterized by progressive skeletal muscle degeneration and atrophy and progressive cardiomyopathy. It has been observed the severity of cardiomyopathy varies in patients with DMD.

Methods and Results

A cohort of male patients with DMD and female DMD carriers underwent whole exome sequencing. Potential risk factor variants were identified according to their functional annotations and frequencies. Cardiac function of 15 male patients with DMD was assessed by cardiac magnetic resonance imaging, and various cardiac magnetic resonance imaging parameters and circulating biomarkers were compared between genotype groups. Five subjects carrying potential risk factor variants in the cystic fibrosis transmembrane regulator gene demonstrated lower left ventricular ejection fraction, larger left ventricular end‐diastolic volume, and higher NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) levels compared with 10 subjects who did not carry the potential risk factor variants (
P
=0.023, 0.019 and 0.028, respectively).

Conclusions
This study revealed heterozygous cystic fibrosis transmembrane regulator gene missense variants were associated with worse cardiac function in patients with DMD. The cystic fibrosis transmembrane regulator gene may serve as a genetic modifier that accounts for more severe cardiomyopathy in patients with DMD, who would require more aggressive management of the cardiomyopathy.
China’s Geostrategic Interests in the Indian Ocean Region: Implications for Kenya
Authors: Odhiambo Paul 
Published: October 2020

Abstract
China’s growing influence in the Indian Ocean cannot be gainsaid as the East Asian economic powerhouse engages in a series of activities to secure maritime routes for energy supplies; to guarantee its trade routes; and to exercise increased maritime influence on the sea lines of communication (SLOCs). Since the beginning of the 21st century, Beijing has enhanced its presence in the Indian Ocean Region (IOR) through construction of ports, increased Chinese naval presence, participation in anti-piracy operations in the Gulf of Aden, construction of a military base in Djibouti, One belt One road initiative and 21st century Maritime Silk Road. While China reassures of its peaceful development, critics contend that Beijing’s military-strategic intentions are aimed at dominance in the Indian Ocean. Countries of the IOR are a home to 2.5 billion people. About 80 percent of the world’s maritime oil trade flows through three chokepoints in the Indian Ocean. Moreover, Indian Ocean is emerging as a pivotal zone due to fast growing economies in the region. Due to its geostrategic significance, the Indian Ocean is expected to play a considerable role in the development of East African littoral states including Kenya. This paper analyzes the growing presence of China in IOR and how Nairobi’s engagement with Beijing could enable Kenya to realize its geostrategic interests in the Indian Ocean. The paper recommends that Kenya needs to have effective strategies to maximize the potential from its exclusive economic zone and secure its national interests as a littoral state.
The Florida Water and Climate Alliance (FloridaWCA): Developing a Stakeholder–Scientist Partnership to Create Actionable Science in Climate Adaptation and Water Resource Management
Authors: Misra Vasubandhu , Irani Tracy , Staal Lisette , Morris Kevin , Asefa Tirusew , Martinez Chris , Graham Wendy 
Published: October 2020

AbstractThe Florida Water and Climate Alliance (FloridaWCA) is a stakeholder–scientist partnership committed to increasing the relevance of climate science data and tools at time and space scales needed to support decision-making in water resource management, planning, and supply operations in Florida. Since 2010, a group of university researchers, public utility water resource managers and operators, water management district personnel, and local planners have engaged in a sustained collaboration for the development, sharing, and application of cutting-edge research to the practical issues of water management and distribution in the highly urbanized state of Florida. The authors, all members of FloridaWCA, present a case study of the organization’s history, its achievements, and lessons learned at the organizational, scientific/technical, and personal levels. Their goals are to 1) describe how the organizational process has contributed to actionable science based on posing and answering questions of importance; 2) share its scientific impact and technical contributions; 3) demonstrate the value of such a stakeholder–scientist partnership, and 4) identify organizational and structural components that have influenced its effectiveness, including personal reflections. The FloridaWCA, having reached its tenth anniversary, continues to evolve today as a sustained stakeholder–scientist partnership resulting in both guiding researchers of what is applicable in the field (creating an area of research that is useful to society) while also helping the practitioners to push the envelope on the state-of-the practices that can be informed by current research.
Squall Line Response to Coastal Mid-Atlantic Thermodynamic Heterogeneities
Authors: Lombardo Kelly 
Published: October 2020

AbstractIdealized 3D numerical simulations are used to quantify the impact of moving marine atmospheric boundary layers (MABLs) on squall lines in an environment representative of the U.S. mid-Atlantic coastal plain. Characteristics of the MABL, including depth and potential temperature, are varied. Squall lines are most intense while moving over the deepest MABLs, while the storm encountering no MABL is the weakest. Storm intensity is only sensitive to MABL temperature when the MABL is sufficiently deep. Collisions between the storm cold pools and MABLs transition storm lift from surface-based cold pools to wavelike features, with the resulting ascent mechanism dependent on MABL density, not depth. Bores form when the MABL is denser than the cold pool and hybrid cold pool–bores form when the densities are similar. While these features support storms over the MABL, the type of lifting mechanism does not control storm intensity alone. Storm intensity depends on the amplification and maintenance of these features, which is determined by the ambient conditions. Isolated convective cells form ahead of squall lines prior to the cold pool–MABL collision, resulting in a rain peak and the eventual discrete propagation of the storms. Cells form as storm-generated high-frequency gravity waves interact with gravity waves generated by the moving marine layers, in the presence of reduced stability by the squall line itself. No cells form in the presence of the storm or the MABL alone.
Marine Boundary Layers above Heterogeneous SST: Across-Front Winds
Authors: Sullivan Peter P. , McWilliams James C. , Weil Jeffrey C. , Patton Edward G. , Fernando Harindra J. S. 
Published: October 2020

AbstractTurbulent flow in a weakly convective marine atmospheric boundary layer (MABL) driven by geostrophic winds Ug = 10 m s−1 and heterogeneous sea surface temperature (SST) is examined using fine-mesh large-eddy simulation (LES). The imposed SST heterogeneity is a single-sided warm or cold front with temperature jumps Δθ = (2, −1.5) K varying over a horizontal distance between [0.1, −6] km characteristic of an upper-ocean mesoscale or submesoscale regime. A Fourier-fringe technique is implemented in the LES to overcome the assumptions of horizontally homogeneous periodic flow. Grid meshes of 2.2 × 109 points with fine-resolution (horizontal, vertical) spacing (δx = δy, δz) = (4.4, 2) m are used. Geostrophic winds blowing across SST isotherms generate secondary circulations that vary with the sign of the front. Warm fronts feature overshoots in the temperature field, nonlinear temperature and momentum fluxes, a local maximum in the vertical velocity variance, and an extended spatial evolution of the boundary layer with increasing distance from the SST front. Cold fronts collapse the incoming turbulence but leave behind residual motions above the boundary layer. In the case of a warm front, the internal boundary layer grows with downstream distance conveying the surface changes aloft and downwind. SST fronts modify entrainment fluxes and generate persistent horizontal advection at large distances from the front.
Assimilation of Satellite Microwave Observations over the Rainbands of Tropical Cyclones
Authors: Moradi Isaac , Evans K. Franklin , McCarty Will , Cordero-Fuentes Marangelly , Gelaro Ronald , Black Robert A. 
Published: October 2020

AbstractA novel Bayesian Monte Carlo integration (BMCI) technique was developed to retrieve geophysical variables from satellite microwave radiometer data in the presence of tropical cyclones. The BMCI technique includes three steps: generating a stochastic database, simulating satellite brightness temperatures using a radiative transfer model, and retrieving geophysical variables such as profiles of temperature, relative humidity, and cloud liquid and ice water content from real observations. The technique also provides uncertainty estimates for each retrieval and can output the error covariance matrix of selected parameters. The measurements from the Advanced Technology Microwave Sounder (ATMS) on board Suomi National Polar-Orbiting Partnership (Suomi NPP) and the Global Precipitation Measurement (GPM) Microwave Imager (GMI) were used as input. A new technique was developed to correct the ATMS and GMI observations for the beam-filling effect, which is due to small-scale variability of precipitation and clouds when compared with the instrument footprint and also the nonlinear relation between the brightness temperature and precipitation. In addition, the assimilation of the BMCI retrievals into the NASA GEOS model is discussed for Hurricane Maria. The results show that assimilating the BMCI retrievals can influence the dynamical features of the cyclone, including a stronger warm core, a symmetric eye, and vertically aligned wind columns. Two possible factors that may limit the impact of the BMCI retrievals include 1) the resolution of the model (about 25 km), which was too coarse to show the potential of the BMCI data in improving the representation of tropical storms in the model forecast, and 2) the data assimilation system not being able to consider vertically correlated observation errors.
A Convection Parameterization for Low-CAPE Environments
Authors: McTaggart-Cowan Ron , Vaillancourt Paul A. , Separovic Leo , Corvec Shawn , Zadra Ayrton 
Published: October 2020

AbstractNumerical models that are unable to resolve moist convection in the atmosphere employ physical parameterizations to represent the effects of the associated processes on the resolved-scale state. Most of these schemes are designed to represent the dominant class of cumulus convection that is driven by latent heat release in a conditionally unstable profile with a surplus of convective available potential energy (CAPE). However, an important subset of events occurs in low-CAPE environments in which potential and symmetric instabilities can sustain moist convective motions. Convection schemes that are dependent on the presence of CAPE are unable to depict accurately the effects of cumulus convection in these cases. A mass-flux parameterization is developed to represent such events, with triggering and closure components that are specifically designed to depict subgrid-scale convection in low-CAPE profiles. Case studies show that the scheme eliminates the “bull’s-eyes” in precipitation guidance that develop in the absence of parameterized convection, and that it can represent the initiation of elevated convection that organizes squall-line structure. The introduction of the parameterization leads to significant improvements in the quality of quantitative precipitation forecasts, including a large reduction in the frequency of spurious heavy-precipitation events predicted by the model. An evaluation of surface and upper-air guidance shows that the scheme systematically improves the model solution in the warm season, a result that suggests that the parameterization is capable of accurately representing the effects of moist convection in a range of low-CAPE environments.
Comparisons of Hybrid En3DVar with 3DVar and EnKF for Radar Data Assimilation: Tests with the 10 May 2010 Oklahoma Tornado Outbreak
Authors: Kong Rong , Xue Ming , Liu Chengsi , Jung Youngsun 
Published: October 2020

AbstractIn this study, a hybrid En3DVar data assimilation (DA) scheme is compared with 3DVar, EnKF, and pure En3DVar for the assimilation of radar data in a real tornadic storm case. Results using hydrometeor mixing ratios (CVq) or logarithmic mixing ratios (CVlogq) as the control variables are compared in the variational DA framework. To address the lack of radial velocity impact issues when using CVq, a procedure that assimilates reflectivity and radial velocity data in two separate analysis passes is adopted. Comparisons are made in terms of the root-mean-square innovations (RMSIs) as well as the intensity and structure of the analyzed and forecast storms. For pure En3DVar that uses 100% ensemble covariance, CVlogq and CVq have similar RMSIs in the velocity analyses, but errors grow faster during forecasts when using CVlogq. Introducing static background error covariance at 5% in hybrid En3DVar (with CVlogq) significantly reduces the forecast error growth. Pure En3DVar produces more intense reflectivity analyses than EnKF that more closely match the observations. Hybrid En3DVar with 50% outperforms other weights in terms of the RMSIs and forecasts of updraft helicity and is thus used in the final comparison with 3DVar and EnKF. The hybrid En3DVar is found to outperform EnKF in better capturing the intensity and structure of the analyzed and forecast storms and outperform 3DVAR in better capturing the intensity and evolution of the rotating updraft.
Inhibitors and mortality in persons with nonsevere hemophilia A in the United States
Authors: Lim Ming Y. , Cheng Dunlei , Recht Michael , Kempton Christine L. , Key Nigel S. 
Published: October 2020

AbstractAlthough persons with nonsevere hemophilia A (NSHA) account for about one-half of the hemophilia A population, epidemiological data in this subset of individuals are scarce. We set out to describe the clinical characteristics of persons with NSHA with inhibitors, and to determine mortality rates, predictors of mortality, and primary causes of death in persons with NSHA in the United States over a 9-year period (2010-2018). We queried the American Thrombosis and Hemostasis Network dataset (ATHNdataset) for information on demographics, inhibitor status, and date and cause of death. A total of 6624 persons with NSHA (86.0% men; 14.0% women) were observed for an average of 8.5 years; total 56 119 person-years . The prevalence of inhibitors was 2.6% (n = 171), occurring at a median age of 13 years. At the end of follow-up, 136 persons died at a median age of 63 years; an age-adjusted mortality rate of 3.3 deaths per 1000 person-years. Three deaths occurred in inhibitor participants. Presence of inhibitors was not associated with increased mortality risk (hazard ratio [HR], 0.7, 95% confidence interval [CI], 0.2-2.3). Factors independently associated with increased risk of death (HR, 95% CI) were the following: age (10-year increase) (2.1, 2.0-2.4); male (2.6, 1.0-6.4); hepatitis C (2.2, 1.5-3.1); and HIV (3.6, 2.2-6.0). The most common primary cause of death was malignancy (n = 27, 20.0%). In persons with NSHA, the development of inhibitors occurred at an early age and was not associated with increased mortality.