bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ist eine Delegation ärztlicher Leistungen auf rheumatologische Fachassistenten bei der Evaluierung von Patienten mit Verdacht auf ankylosierende Spondylitis möglich? – Ergebnisse der PredAS-Studie
Authors: Kiltz U. , Spiller I. , Sieper J. , Braun J. 
Published: July 2020

Zusammenfassung

Hintergrund
Der oft langsame Beginn einer axialen Spondyloarthritis (axSpA), die initial zum Teil wenig spezifischen Symptome (Rückenschmerzen), aber auch begrenzte Ressourcen und die damit verbundenen Verzögerungen in der rheumatologischen Versorgung sind Faktoren, die zu verspäteter Diagnose und Therapie dieser meist jungen Patienten mit beitragen. Rheumatologische Fachassistenten (RFA) können zur Verbesserung der Versorgung beitragen, indem sie vom Rheumatologen delegierte ärztliche Leistungen übernehmen.

Ziel der Arbeit
Ziel ist, zu untersuchen, ob geschulte RFA bei Patienten mit chronischem Rückenschmerz und noch unklarer Diagnose mithilfe eines strukturierten Fragebogens anamnestische und klinische Befunde wie Rheumatologen erheben können.

Material und Methoden
In der multizentrisch durchgeführten PredAS-Studie wurden bei Patienten mit dem Leitsymptom chronischer Rückenschmerz demografische Basisdaten, Anamnese und patientenberichtete Endpunkte mittels strukturierter Fragebögen von RFA und Rheumatologen unabhängig voneinander erfasst. Zudem wurden Funktion (BASFI) und Wirbelsäulenbeweglichkeit (BASMI) standardisiert gemessen. Um die mögliche Erleichterung durch Nutzung digitaler Medien zu testen, wurden 2 Patientengruppen getrennt untersucht: Die Ergebnisse der einen Kohorte wurden mittels papierbasierter Case Report Forms (CRF) und die Ergebnisse der anderen elektronisch mittels iPad dokumentiert. Die Konkordanz der Dokumentationen zwischen RFA und Rheumatologen wurde als Kappa-Koeffizient, als prozentuale Übereinstimmung und auf individueller Patientenebene berechnet.

Ergebnisse
Bei fast drei Viertel der 141 Patienten mit chronischen Rückenschmerzen wurden Charakteristika des entzündlichen Rückenschmerzes identifiziert. Die Konkordanz bei Dokumentation durch RFA und Arzt war bei den anamnestischen Angaben zum Rückenschmerz höher als bei der Angabe zur Lokalisation des Rückenschmerzes. Bei der Erhebung des BASMI zeigte sich kein Unterschied zwischen RFA und Arzt (ICC 0,925) (95 %-CI 0,879–0,953). Der Zeitaufwand für die strukturierte Dokumentation betrug beim Arzt 20 ± 6,7 min und bei der RFA 28,5 ± 13 min.

Diskussion
Die Ergebnisse sprechen dafür, dass geschulte RFA die Rheumatologen bei der anamnestischen Aufarbeitung und ersten körperlichen Untersuchung im Rahmen der Diagnosestellung erheblich und qualifiziert unterstützen können.
Mutual conditional independence and its applications to model selection in Markov networks
Authors: Gauraha Niharika , Parui Swapan K. 
Published: July 2020

AbstractThe fundamental concepts underlying Markov networks are the conditional independence and the set of rules called Markov properties that translate conditional independence constraints into graphs. We introduce the concept of mutual conditional independence in an independent set of a Markov network, and we prove its equivalence to the Markov properties under certain regularity conditions. This extends the notion of similarity between separation in graph and conditional independence in probability to similarity between the mutual separation in graph and the mutual conditional independence in probability. Model selection in graphical models remains a challenging task due to the large search space. We show that mutual conditional independence property can be exploited to reduce the search space. We present a new forward model selection algorithm for graphical log-linear models using mutual conditional independence. We illustrate our algorithm with a real data set example. We show that for sparse models the size of the search space can be reduced from$\mathcal {O} (n^{3})$O(n3)to$\mathcal {O}(n^{2})$O(n2)using our proposed forward selection method rather than the classical forward selection method. We also envision that this property can be leveraged for model selection and inference in different types of graphical models.
When management meets science: adaptive analysis for the optimization of the eradication of the Northern raccoon (Procyon lotor)
Authors: Mazzamuto Maria Vittoria , Panzeri M. , Bisi F. , Wauters L. A. , Preatoni D. , Martinoli A. 
Published: July 2020

AbstractThe EU Regulation no.1143/2014 on invasive species requires the EU Member States to respond promptly and efficiently in eradicating the invasive alien species listed as species of Union concern. The Northern raccoon (Procyon lotor) was introduced in Northern Italy along the river Adda and we carried out its eradication campaign between 2016 and 2019. We used an integrated approach of camera traps and live traps. A standardized approach to the camera trap survey (2904 camera trap-nights) revealed that the detectability of raccoons (0.27 ± 0.07 SD) increased in the proximity of the river and their occupancy (0.15 ± 0.09 SD) was higher in urban areas. These results allowed us to increase the trapping success whilst reducing the effort. During the captures, systematic collection of catch and effort data allowed to estimate population size (65 ± 7.8 raccoons) and thus to have a continuous update on how far the campaign was from the complete eradication of the species, allowing to adjust the trapping effort accordingly. We captured 69 raccoons (7279 cage trap nights) thanks to both systematic trapping and opportunistic activation of traps following stakeholders’ reports. Stakeholders supported the campaign and some of them played an important role in reporting sightings, signs, and allowing access to their private land. Camera trap data also allowed us to make a Rapid Eradication Assessment that estimated an eradication probability of 99% after 6 months without detections. We finally give indications for future control campaigns on the species to increase removal success, reducing the effort.
Evolution of orbits about comets with arbitrary comae
Authors: Moretto Mark , McMahon Jay 
Published: July 2020

AbstractSpacecraft and natural objects orbiting an active comet are perturbed by gas drag from the coma. These gases expand radially at about 0.5 km/s, much faster than orbital velocities that are on the order of meters per second. The coma has complex gas distributions and is difficult to model. Accelerations from gas drag can be on the same order of gravity and are currently poorly understood. Semi-analytical solutions for the evolution of the Keplerian orbital elements of a spacecraft orbiting a comet using simplified drag and coma models are derived using a Fourier series expansion in the argument of latitude. It is found that the mean element evolution is only dependent on the zeroth- and first-order terms of the Fourier series expansion. For an arbitrary, inverse-square, radial, perturbing force, there are no frozen orbits; however, the argument of pericenter has a stable equilibrium and an unstable equilibrium and the angular momentum vector of the orbit is constant. Furthermore, the radius of the orbit at two specific angles relative to the ascending node is preserved. The evolution of the orbit is governed by the argument of pericenter, resulting in orientations that raise and lower the radius of pericenter and implying safe and unsafe orbit orientations for spacecraft operations.
Site fidelity of Hippocampus guttulatus Cuvier, 1829 at Mar Piccolo of Taranto (Southern Italy; Ionian Sea)
Authors: Pierri Cataldo , Lazic Tamara , Corriero Giuseppe , Cardone Frine , Onen Tarantini Senem , Desiderato Andrea , Mirto Simone , Gristina Michele 
Published: July 2020

AbstractLack of detailed knowledge on ecological niche, life cycles, spatial distribution, reproductive biology and space use strongly affects the selection of useful tools and measures in the conservation of threatened marine species. Especially for sedentary and slow species, behaviour and movement capacities are supposed to be the most important functional traits. Indeed, behavioural variability concerning available space and the close presence of individuals is considered a crucial trait for the population dynamics assessments, especially when disturbances of various causes are present in the environment. The present study aimed to investigate the site fidelity and degree of movement of Hippocampus guttulatus, an emblematic and threatened Mediterranean seahorse species. With this aim, a number of seahorses were tagged and monitored throughout two years within a limited area of the lagoon of Mar Piccolo of Taranto (Southern Italy). The studied individuals were initially morphometrically measured for size, sex and life-cycle stage and subsequently monitored through repeated four-month surveys each year. Obtained results indicated high site fidelity regardless of habitat type. Movement pattern was in line with the data on congeneric species, although values were slightly higher. The analyses showed differences in movement degree among different sexes and life-cycle stages and indicated greater mobility of adult females compared to males and juveniles. The investigated parameters showed a great variability suggesting that even small-scale environmental factors can influence the species mobility. Finally, a change in the population structure has been observed, with the loss of large individuals in 2016 and reduced recruitment in 2017. These findings indicated the possible presence of stressors that could lead to the alteration of the seahorse population at Mar Piccolo of Taranto.
Irreducibly Thick Evaluation is not Thinly Evaluative
Authors: Cannon N. D. 
Published: July 2020

AbstractIn this paper, I criticize the pairing of irreducible thickness (the view that thick concepts do not reduce to thin evaluations plus some descriptive component) with the traditional view of evaluation which says evaluation is a matter of encoding good or bad in some way. To do this, I first explicate the determination view, which holds that irreducibly thick concepts are to thin concepts as determinates are to determinables. I then show that, even if the determination view did establish irreducible thickness, it would not have proven that the evaluative is well understood as being an instance of the determination relation; in order to do that, the determination view needs to show how the evaluative fit a general analysis of the determination relation. However, when the determination view attempts to fill in the analysis, we get implausible results—so implausible, I claim, that we should see the results as a reductio to the view. To generalize the criticism to any view like the determination view, I show that the same results ensue when we model the evaluative on mereology. Finally, I diagnose the general failure by claiming that the evaluative domain, as conceived by the defender of irreducible thickness, just does not have the structure to secure the tight connection between thick and thin concepts while also carving up our conceptual economy in a plausible way.
Security, Privacy and Risks Within Smart Cities: Literature Review and Development of a Smart City Interaction Framework
Authors: Ismagilova Elvira , Hughes Laurie , Rana Nripendra P. , Dwivedi Yogesh K. 
Published: July 2020

AbstractThe complex and interdependent nature of smart cities raises significant political, technical, and socioeconomic challenges for designers, integrators and organisations involved in administrating these new entities. An increasing number of studies focus on the security, privacy and risks within smart cities, highlighting the threats relating to information security and challenges for smart city infrastructure in the management and processing of personal data. This study analyses many of these challenges, offers a valuable synthesis of the relevant key literature, and develops a smart city interaction framework. The study is organised around a number of key themes within smart cities research: privacy and security of mobile devices and services; smart city infrastructure, power systems, healthcare, frameworks, algorithms and protocols to improve security and privacy, operational threats for smart cities, use and adoption of smart services by citizens, use of blockchain and use of social media. This comprehensive review provides a useful perspective on many of the key issues and offers key direction for future studies. The findings of this study can provide an informative research framework and reference point for academics and practitioners.
Emotional Voice Intonation: A Communication Code at the Origins of Speech Processing and Word-Meaning Associations?
Authors: Filippi Piera 
Published: July 2020

AbstractThe aim of the present work is to investigate the facilitating effect of vocal emotional intonation on the evolution of the following processes involved in language: (a) identifying and producing phonemes, (b) processing compositional rules underlying vocal utterances, and (c) associating vocal utterances with meanings. To this end, firstly, I examine research on the presence of these abilities in animals, and the biologically ancient nature of emotional vocalizations. Secondly, I review research attesting to the facilitating effect of emotional voice intonation on these abilities in humans. Thirdly, building on these studies in animals and humans, and through taking an evolutionary perspective, I provide insights for future empirical work on the facilitating effect of emotional intonation on these three processes in animals and preverbal humans. In this work, I highlight the importance of a comparative approach to investigate language evolution empirically. This review supports Darwin’s hypothesis, according to which the ability to express emotions through voice modulation was a key step in the evolution of spoken language.
Fluid Flow Characterization Framework for Naturally Fractured Reservoirs Using Small-Scale Fully Explicit Models
Authors: Wong Daniel Lorng Yon , Doster Florian , Geiger Sebastian , Francot Eddy , Gouth François 
Published: July 2020

AbstractFlow modelling challenges in fractured reservoirs have led to the development of many simulation methods. It is often unclear which method should be employed. High-resolution discrete fracture and matrix (DFM) studies on small-scale representative models allow us to identify dominant physical processes influencing flow. We propose a workflow that utilizes DFM studies to characterize subsurface flow dynamics. The improved understanding facilitates the selection of an appropriate method for large-scale simulations. Validation of the workflow was performed via application on a gas reservoir represented using an embedded discrete fracture model, followed by the comparison of results obtained from hybrid and dual-porosity representations against fully explicit simulations. The comparisons ascertain that the high-resolution small-scale DFM studies lead to a more accurate upscaled model for full field simulations. Additionally, we find that hybrid implicit–explicit representations of fractures generally outperform pure continuum-based models.
How Do Rapidly Internationalizing SMEs Learn? Exploring the Link Between Network Relationships, Learning Approaches and Post-entry Growth of Rapidly Internationalizing SMEs from Emerging Markets
Authors: Puthusserry Pushyarag , Khan Zaheer , Knight Gary , Miller Kristel 
Published: July 2020

AbstractThis article explores learning among rapidly internationalizing small and medium sized enterprises (SMEs) and how this supports the post-internationalization growth and survival of these firms. We utilize a qualitative multiple case study approach of ten information and communication technology (ICT) SMEs from a key emerging market—India. Findings suggest that during the post-entry stage, rapidly internationalizing SMEs use a wide range of internal and external sources of knowledge. External sources of knowledge include peer networks, associations in the same industry, international clients/partners, and international connections developed through trade fairs and trade missions. Internal sources of knowledge such as self-learning, especially from trial-and-error and experiential efforts, were found to enhance product, market and technological knowledge; and consequently aided geographic and product diversification. The findings also indicate that firms use a mix of integrated, vicarious, congenital and experiential learning approaches in their post-entry growth and survival phases. Experiential and congenital learning were found to be facilitated by firms’ internal network sources, whereas external network sources provide an ideal platform for vicarious learning. The study provides new insights into networking and learning by providing evidence that exposure to and connection with diverse types of networks can result in various forms of valuable learning for rapidly internationalizing SMEs, which enhances their post-entry growth.
Connected Surveillance for Detection of Complications After Early Discharge from Bariatric Surgery
Authors: Neuberg Maud , Blanchet Marie-Cécile , Gignoux Benoit , Frering Vincent 
Published: July 2020

AbstractAs part of a bariatric enhanced recovery after surgery (ERAS) program, at-home follow-up using a novel Internet application was used to detect early complications. The study aimed to evaluate the safety and effectiveness of this “connected surveillance” protocol over a 10-day follow-up. Patients were monitored 24/7 by a trained nursing team with daily surgeon review of patient self-reports. Morbidly obese patients (n = 281) underwent OAGB (126, 47.70%) or sleeve gastrectomy (138, 52.3%). Of 264 who completed the study (mean age 40 years [20–66]), 3 (1.1%) underwent revision for early complications; there were 6 (2.1%) readmissions and 22 (8.3%) consultations. In a bariatric surgery ERAS program, “Internet-connected surveillance” proved safe and effective in detecting 100% of early complications, and most patients were satisfied with their care.
Compound heterozygous GLI3 variants in siblings with thyroid hemiagenesis
Authors: Szczepanek-Parulska Ewelina , Budny Bartłomiej , Borowczyk Martyna , Zawadzka Katarzyna , Sztromwasser Paweł , Ruchała Marek 
Published: July 2020

Abstract
Purpose
Thyroid hemiagenesis (THA) is an inborn absence of one thyroid lobe of largely unknown etiopathogenesis, affecting 0.05–0.5% population. The aim of the study was an identification of genetic factors responsible for thyroid maldevelopment in two siblings with THA.

Methods
We evaluated a three-generation THA family with two sisters presenting the disorder. Proband (Patient II:3) was diagnosed at the age of 45 due to neck asymmetry. Left lobe agenesis and nontoxic multinodular goiter were depicted. Proband’s sister (Patient II:6) was euthyroid, showed up at the age of 39 due to neck discomfort and left-sided THA was demonstrated. Affected individuals were subjected to whole-exome sequencing (WES) (Illumina, TruSeq Exome Kit) and all identified variants were evaluated for pathogenicity. Sanger sequencing was used to confirm WES data and check segregation among first-degree relatives.

Results
In both siblings, a compound heterozygous mutations NM_000168.6: c.[2179G>A];[4039C>A] (NP_000159.3: p.[Gly727Arg];[Gln1347Lys]) were identified in the GLI3 gene, affecting exon 14 and 15, respectively. According to the American College of Medical Genetics, variants are classified as of uncertain significance, and were found to be very rare (GnomAD MAF 0.007131 and 0.00003187). The segregation mapping and analysis of relatives indicated causativeness of compound heterozygosity.

Conclusions
We demonstrated for the first time a unique association of THA phenotype and the presence of compound heterozygous mutations p.[Gly727Arg];[Gln1347Lys] of GLI3 gene in two siblings.
Palaeofloral Investigation Based on Morphotaxonomy, Palynomorphs, Biomarkers and Stable Isotope from Lalmatia Coal Mine of Rajmahal Lower Gondwana Basin, Godda District, Jharkhand: An Inclusive Empirical Study
Authors: Pillai S. Suresh Kumar , Mathews Runcie Paul , Murthy Srikanta , Goswami Shreerup , Agrawal Shailesh , Sahoo Mrutyunjaya , Singh Ranjit Kumar 
Published: July 2020

Abstract
A rich Glossopteris dominated plant fossils assemblage is recovered from the Barakar Formation of Lalmatia coal mine, Hura coalfield of Rajmahal Basin, Godda district, Jharkhand, India. The assemblage includes Glossopteris, Gangamopteris and Noeggerathiopsis (leaf forms) along with Vertebraria (root form). There are 4 genera and 14 species of megafossils in the collection, which includes 10 species of Glossopteris, two species of Gangamopteris and one species of Noeggerathiopsis and Vertebraria each. The flora, although similar to that of the Barakar Formation of the Damodar Basin complex, exhibit unique characteristics and is of Artinskian to Kungurian in age. The palynoassemblage recovered in the section reveals the dominance of genus Scheuringipollenites and sub–dominance of Faunipollenites (=Protohaploxypinus) along with Parasaccites, Potonieisporites, Barakarites, Plicatipollenites, Striomonosaccites, Striatopodocarpites, Crescentipollenites, Verticipollenites, Rhizomaspora, Distriatites, Primuspollenites, Striasulcites, Lunatisporites, Guttulapollenites, Platysaccus, Microfoveolatispora, Micro-baculispora, Horriditriletes, Tiwariasporis and Weylandites, which demonstrates an early Permian age (Artinskian). The palyno-assemblage indicates that the sediments belong to the lower part of the Barakar Formation. Biomarker analysis suggests varying organic matter input during the deposition of the studied sequence. Diterpane compounds and megafossil evidences suggest Glossopteris were the dominant flora along with conifers. Bacterial alteration of the organic matter is inferred from the hopane compounds. The δ13C value of organic matter associated with the carbonaceous shale directly corroborates with the typical δ13C values of the Permian time and is suggestive of warm and humid climatic conditions.
Bringing ‘Deep Knowledge’ of Fisheries into Marine Spatial Planning
Authors: Said Alicia , Trouillet Brice 
Published: July 2020

AbstractIn marine spatial planning (MSP), the production of knowledge about marine-based activities is fundamental because it informs the process through which policies delineating the use of space are created and maintained. This paper revises our view of knowledge—developed during the mapping and planning processes—as the undisputed factual basis on which policy is developed. Rather, it argues that the construction, management, validation, and marginalisation of different types of knowledge stemming from different stakeholders or disciplinary approaches is at the heart of policy and planning processes. Using the case of fisheries-generated knowledge in the implementation of MSP, we contend that the fisheries data informing the MSP process are still very much streamlined to classical bio-economic metrics. Such metrics fall short of describing the plural and complex knowledges that comprise fisheries, such as localised social and cultural typologies, as well as the scale and dynamics, hence, providing incomplete information for the decision-making process of MSP. In this paper, we provide a way to move towards what we conceptualize as ‘Deep Knowledge’ and propose a model that brings together of the existing datasets and integrates socio-cultural data as well as complex spatiotemporal elements, to create dynamic rather than static datasets for MSP. We furthermore argue that the process of knowledge production and the building of the parameters of such datasets, should be based on effective stakeholder participation, whose futures depend on the plans that eventually result from MSP. Finally, we recommend that the ‘Deep Knowledge’ model is adopted to inform the process of knowledge production currently being undertaken in the diverse countries engaging in the MSP process. This will result in policies that truly reflect and address the complexities that characterise fisheries, and which are legitimized through a process of knowledge co-production.