bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postpartum mood among universally screened high and low socioeconomic status patients during COVID-19 social restrictions in New York City.
Authors: Silverman Michael E. , Burgos Laudy , Rodriguez Zoe I. , Afzal Omara , Kalishman Alyssa , Callipari Francesco , Pena Yvon , Gabay Ruth , Loudon Holly 
Published: August 2020

Abstract
Introduction: The mental health effects of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Coronavirus disease 2019 (COVID-19) pandemic on postpartum women is of increasing concern among mental health practitioners. To date only a handful of studies have explored the impact of the pandemic during pregnancy and none have attempted explore the impact of pandemic related social restrictions on postpartum mood.Methods: Postpartum patients appearing to the Mount Sinai Health System for their postpartum appointment between January 2, 2020 and June 30, 2020, corresponding to before and during pandemic imposed social restrictions, were screened for mood symptomatology using the Edinburgh Postnatal Depression Scale (EPDS). Each patient’s socioeconomic status (SES; high/low) was determined by their location of clinical service.Results: 516 postpartum patients were screened. While no differences in EPDS scores were observed by SES prior to social restrictions (t(262)=0.23, p=.82), a significant change in mood symptomatology was observed following COVID-19 restrictions (t(288)=2.32, p<.02), with patients living in lower SES reporting significantly less depression symptomatology (t(321)=4.07, p<.01). There was no change in symptomatology among patients of higher SES (t(191)=0.59, p=0.56).Discussion: Postpartum depression, the most common complication of childbearing, is a prevalent, cross-cultural disorder with significant morbidity. The observed differences in postpartum mood between patients of different SES in the context of temporarily imposed COVID-19 related social restrictions present a unique opportunity to better understand the specific health and social support needs of postpartum patients living in urban poverty. Given that maternal mental illness has negative long-term developmental implications for the offspring, and that poor mental health reinforces the poverty cycle, future policy specifically directed towards supporting urban postpartum women living in low-SES by ameliorating some of the early maternal mental health burdens associated with balancing employment-family-childcare demands may assist in interrupting this cycle while simultaneously improving the long-term outcomes of their offspring.
Pain-Guided Activity Modification During Treatment for Patellar Tendinopathy: A Feasibility and Pilot Randomized Clinical Trial
Authors: Sprague Andrew L , Couppé Christian , Pohlig Ryan T. , Snyder-Mackler Lynn Sc.D , Silbernagel Karin Grävare 
Published: August 2020

Abstract
Background: Activity modification is a key component of patellar tendinopathy treatment but there is a lack of evidence guiding activity modification prescription. Use of activity modification in treatment studies has varied widely and the impact of those recommendations has not been directly investigated or compared. The purpose of this study was to assess 1) the feasibility of using pain-guided activity modification during treatment for patellar tendinopathy and 2) if our outcome measures are responsive to changes in tendon health over the course of treatment.Methods: This was an unblinded, randomized two-arm pilot and feasibility study randomized clinical trial with parallel assignment, conducted in Newark, DE. Individuals between the ages of 16 and 40 years old with patellar tendinopathy were included. Participants were randomly assigned to a pain-guided activity (PGA) or pain-free activity (PFA) group using a spreadsheet-based randomization scheme. All participants received standardized treatment using a modified version of the heavy-slow resistance protocol 3x/week for 12-weeks. For the first six weeks, the PGA group used the Pain-Monitoring Model to guide activity outside of treatment and the PFA group was restricted from running, jumping, or activities that provoked their patellar tendon pain. Feasibility outcomes included recruitment, enrollment, randomization, compliance, and retention percentages. Clinical evaluations were conducted at baseline, 6- and 12-weeks to assess symptom severity, psychological factors, tendon morphology and mechanical properties, lower extremity function and quadriceps muscle performance. Results: In a ~13 month period, 108 individuals were screened, 47/108 (43.5%) were eligible for participation, and 15/47 (32.0%) of those were enrolled (9 PGA, 6 PFA). The recruitment rate was 1.15 participants/month. The mean±SD compliance with treatment was PGA: 86.1±13.0% and PFA: 67.1±30.7%. There was one missed evaluation session and two adverse events, which were not due to study interventions. Changes exceeding the smallest detectable change were observed for at least one outcome in each domain of tendon health.Conclusions: Use of pain-guided activity modification during exercise therapy for patellar tendinopathy was found to be feasible, and the proposed outcome measures appropriate. Computer-based allocation concealment, blinding of evaluators, and greater recruitment of high-level athletes should be implemented in future trials. Trial Registration: ClinicalTrials.gov identifier: NCT03694730. Registered 3rd of October, 2018. https://clinicaltrials.gov/ct2/show/NCT03694730
Prediction of the Date of Flex and of the Date of Substantial Reduction in the Number of COVID – 19 Confirmed Cases and Fatalities in Delhi (India)
Authors: .ARORA B. L 
Published: August 2020

Abstract
In this paper, we analyse the covidCovid-19 data of the number of confirmed positive infectious cases (I) in Delhi - the capital of India – a city with a population of nearly 20 million - from April 1, 2020 to July 27th 2020 to find the flex in the I-t curve, where the second derivative of the I - t curve becomes negative. i.e. the date from which the rate of growth of the number of infections starts decreasing. The data isare fitted to the Gauss error function formulaa + b erf(cx-d)with four parameters a, b, c and d as was done by Ciufolini and Paolozzi [1] for analysis of the covid-19 data of Italy and China. The date of flex is also found by plotting the second derivative of I evaluated numerically and agrees with the date found by the Gauss error function method. We also determinedetermined the date at which the number of new daily infections iswas sufficiently reduced to aboutapproximately 100. An estimate of the number of future cases is calculated using the Gauss error function. The data for the number of fatalities in the city isare also fitted to the Gauss error function with four parameters, and we estimate the date at which the number of fatalities reduces in proportion to a sufficient reduction in the number of new Covid-19 cases, which in this case is approximately 3. The data for the analysis hashave been taken from the website covid19India.org and Aarogya Setu App [6] of the Government of India.
Perspectives in Breast and Ovarian Cancer Chemotherapy by Nanomedicine Approach: Nanoformulations in Clinical Research
Authors: Martín-Sabroso Cristina , Fraguas-Sánchez Ana Isabel , Raposo-González Rafaela , Torres-Suárez Ana Isabel 
Published: August 2020

Background:
Breast and ovarian carcinomas represent major health problems in
women worldwide. Chemotherapy constitutes the main treatment strategy, and the use of
nanocarriers, a good tool to improve it. Several nanoformulations have already been approved,
and others are under clinical trials for the treatment of both types of cancers.

Objective:
This review focuses on the analysis of the nanoformulations that are under clinical
research in the treatment of these neoplasms.

Results:
Currently, there are 6 nanoformulations in clinical trials for breast and ovarian
carcinomas, most of them in phase II and phase III. In the case of breast cancer treatment,
these nanomedicines contain paclitaxel; and, for ovarian cancer, nanoformulations containing
paclitaxel or camptothecin analogs are being evaluated. The nanoencapsulation of these
antineoplastics facilitates their administration and reduces their systemic toxicity.
Nevertheless, the final approval and commercialization of nanoformulations may be limited
by other aspects like lack of correlation between the efficacy results evaluated at in vitro and
in vivo levels, difficulty in producing large batches of nanoformulations in a reproducible
manner and high production costs compared to conventional formulations of antineoplastics.
However, these challenges are not insurmountable and the number of approved
nanoformulations for cancer therapy is growing.

Conclusion:
Reviewed nanoformulations have shown, in general, excellent results, demonstrating
a good safety profile, a higher maximum tolerated dose and a similar or even slightly
better antitumor efficacy compared to the administration of free drugs, reinforcing the use of
nano-chemotherapy in both breast and ovarian tumors.
Synthesis, Characterization and Antimicrobial Activities of 1,4- Disubstituted 1,2,3-Triazole Compounds
Authors: Insa Seck , Alioune Fall , Aicha Ba Lalla , Fama Ndoye Samba , Seydou Ka , Abdoulaye Diop , Ismaïla Ciss , Abda Ba , Amadou Diop , Sadibou Boye Cheikh , Generosa Gomez , Yagamare Fall , Matar Seck 
Published: August 2020

Background:
1,2,3-triazoles are five-membered heterocyclic scaffold; their broad-spectrum
biological activities are known. Researchers around the world are increasingly being interested in this
emerging area, owing to its immense pharmacological scope.

Objective:
This work summarizes the synthesis of 1,2,3-triazoles and the significance of this pattern as a
lead structure for new drug molecules discovery.

Methods:
1,2,3-triazoles can be obtained on a multigram scale through “click chemistry” under ambient
conditions.

Results:
Sixteen compounds were synthesized and evaluated on five microbial strains E. coli, E. faecalis,
P. aeruginosa, S. aureus and C. albicans. NMR, MS and IR were used to characterize all compounds.
They were evaluated with their Minimum Inhibitory Concentrations (MICs) and interesting results
were obtained with compounds 12a, 12b, 3, 2a and 2c, with MIC 0.14 μM (P. aeruginosa), 1.08
μM (E. coli), 1.20 μM (E. faecalis and C. albicans), 3.5 μM (E. faecalis) and 4.24 μM (C. albicans),
respectively. P. aeruginosa and C. albicans were the most sensitive among all the strains.

Conclusion:
The synthesized compounds were found as potential antimicrobial agents against Gram (+),
Gram (-) strains and fungi.
Novel Iodinated Hydrazide-hydrazones and their Analogues as Acetyl- and Butyrylcholinesterase Inhibitors
Authors: Krátký Martin , Štěpánková Šárka , Brablíková Michaela , Svrčková Katarína , Švarcová Markéta , Vinšová Jarmila 
Published: August 2020

Background:
Hydrazide-hydrazones have been known as scaffold with various biological
activities including inhibition of acetyl- (AChE) and butyrylcholinesterase (BuChE). Cholinesterase inhibitors
are mainstays of dementias’ treatment.

Objective:
Twenty-five iodinated hydrazide-hydrazones and their analogues were designed as potential
central AChE and BuChE inhibitors.

Methods:
Hydrazide-hydrazones were synthesized from 4-substituted benzohydrazides and 2-/4-
hydroxy-3,5-diiodobenzaldehydes. The compounds were investigated in vitro for their potency to inhibit
AChE from electric eel and BuChE from equine serum using Ellman’s method. We calculated also
physicochemical and structural parameters for CNS delivery.

Results:
The derivatives exhibited a moderate dual inhibition with IC50 values ranging from 15.1-140.5
and 35.5 to 170.5 μmol.L-1 for AChE and BuChE, respectively. Generally, the compounds produced a
balanced or more potent inhibition of AChE. N'-[(E)-(4-Hydroxy-3,5-diiodophenyl)methylidene]-4-
nitrobenzohydrazide 2k and 4-fluoro-N'-(2-hydroxy-3,5-diiodobenzyl)benzohydrazide 3a were the most
potent inhibitors of AChE and BuChE, respectively. Structure-activity relationships were established,
and molecular docking studies confirmed interaction with enzymes.

Conclusion:
Many novel hydrazide-hydrazones showed lower IC50 values than rivastigmine against
AChE and some of them were comparable for BuChE to this drug used for the treatment of dementia.
They interact with cholinesterases via non-covalent binding into the active site. Based on the BOILEDEgg
approach, the majority of the derivatives met the criteria for blood-brain-barrier permeability.
An Integrative Informatics Approach to Explain the Mechanism of Action
of N1-(Anthraquinon-2-yl) Amidrazones as BCR/ABL Inhibitors
Authors: Sabbah Dima A. , Hajjo Rima , Sweidan Kamal , Zhong Haizhen A. 
Published: August 2020

Background:
Drugs incorporating heterocyclic chemical skeletons possess a plethora of therapeutic activities
such as anticancer, antimicrobial, antihypertensive, and antipsychiatric effects. It is becoming routine, nowadays, to use
cheminformatics and bioinformatics methods to elucidate the mechanism(s) of action of such drugs.

Objective:
To probe the activity of a recently published series of N1-(anthraquinon-2-yl) amidrazone piperazine derivatives
employing computational strategies[1], identify their structural basis of binding to BCR/ABL kinase domain, and explain
their anticancer activities in human breast adenocarcinoma (MCF-7) and chronic myelogenous leukemia (K562) cell lines.

Methods:
We applied an in silico integrative informatics approach integrating molecular descriptors, docking studies,
cheminformatics, and network analysis.

Results:
Our results highlighted the possible involvement of the BCR/ABL and DRD2 pathways in the anticancer activity
of the studied compounds, and induced fit docking (IFD) indicated that the BCR/ABL kinase domain is a putative drug
target. Additionally, high-scoring docking poses identified a unique network of hydrogen bonding with amino acids Y253,
K271, E286, V299, L301, T315, M318, I360, R362, V379, and D3810.

Conclusion:
Using an integrative informatics approach to characterize our anticancer compounds, we were able to explain
the biological differences between synthesized and biologically validated amidrazone piperazine anticancer agents. We
were also able to postulate a mechanism of action of this novel group of anticancer agents.
Recombinant Production and Molecular Docking Studies of Casoplatelin, a Bioactive Peptide
Authors: Yennamalli Ragothaman M. , Srivastava Pulkit Anupam , Sarswati Sheena D. , Garlapati Vijay Kumar 
Published: August 2020

Background:
Bioactive peptides from κ-casein have immense therapeutic potential as prophylactic formulations. Among these, casoplatelin is a κ-casein derived bioactive peptide with anti-thrombotic activities.

Aim:
Herein, we report the production of casoplatelin in an E. coli expression system (using a pBAD vector) and show in silico modeling of its interactions.

Methods:
A synthetic DNA construct encoding casoplatelin was designed with pepsin cleavage sites before and after the synthetic construct to allow the release of the peptide from the pro-peptide.

Results:
A novel recombinant approach was demonstrated for the production of casoplatelin, and anti-platelet aggregation activities of the product were confirmed. Also, casoplatelin structures were characterized in silico and then implemented to determine potential structural interactions with fibrinogen.

Conclusion:
The present study showcases the recombinant approach for biopeptide production and its interaction with fibrinogen through in silico approach.
Nursing Students’ Perception of the Clinical Learning Environment
Authors: Alammar Kamila , Ahmad Muayyad , Almutairi Sultanah , Salem Olfat 
Published: August 2020

Introduction:
Clinical learning environment placements provide opportunities for students to develop their skills, socialize to the profession and bridge the gap between academic and workplace learning. This study was conducted to investigate Saudi nursing students’ perceptions of their clinical learning environment and supervision in the hospital setting.

Methods:
A sample of 90 final year student nurses completing practicums at a tertiary hospital in Riyadh was included in this cross-sectional study utilizing the Clinical Learning Environment and Supervision plus Nurse Teacher scale.

Results:
Overall, students perceived their clinical learning environment positively. Among sub-scores, that for the leadership style of ward manager was the highest. Supervision types, nursing-teacher teacher-visit frequency and grade point average positively and significantly impacted student’s perceptions, while university type and practicum duration did not.

Conclusion:
Students confirmed the ward manager’s leadership style as the most significant influencing their perceptions. However, the nursing teacher’s role had the lowest mean score, suggesting the need for its enhancement and clarification and indicating the need for better communication and collaboration between nursing schools and the clinical training hospital.
Effects of a Tennis Match on Perceived Fatigue, Jump and Sprint Performances on Recreational Players
Authors: Amatori Stefano , Gobbi Erica , Moriondo Giorgia , Gervasi Marco , Sisti Davide , Rocchi Marco B.L. , Perroni Fabrizio 
Published: August 2020

Background:
Tennis is an intermittent sport, characterized by hundreds of repetitive explosive efforts, including accelerations, and jumps. A single match can last up to 5 hours and players are called to play several matches often separated by less than 48h of recovery.

Objective:
The study aimed to investigate the effects of a standardized tennis match on perceived fatigue and jump and sprint performances on a group of recreational tennis players and to observe if such variables were affected by residual effects of fatigue 24 hours after the match.

Methods:
Twelve recreational tennis players performed a 120 min match. Before, immediately after and 24h after the match, players completed a set of three countermovement jumps, three 10m sprints, and reported their perception of general fatigue.

Results:
Significant differences between the three conditions have been found for the perceived fatigue: indeed fatigue was higher both in the immediate post (F(1,10)= 54.422, η2 = 0.845, p<0.001) and 24h post-match (F(1,10)= 10.947, η2 = 0.523, p=0.08), with respect to the pre-match condition. No significant differences were detected in the other variables.

Conclusion:
During a tournament, the performance of tennis players may be weakened and the recovery prejudiced. To identify fluctuations of and factors linked to fatigue may help tennis practitioners to apply adequate recovery strategies with athletes, limiting performance decrements within a tournament, and indirectly preventing injuries.
Metabolite Profiling of Different Solvent Extracts of the Microalgae Chlorella vulgaris Via 1H NMR-Based Metabolomics
Authors: Pantami Hamza A. , Shaari Khozirah , Bustamam Muhammad S.A. , Ismail Intan S. 
Published: August 2020

Introduction:
In the present study, profiling of the cultured Chlorella
vulgaris metabolome was carried out via1H NMR metabolite profiling of 6 different
solvent extracts. The results indicated that the six solvent extracts have
metabolite profiles that are clearly different from each other.

Methods:
Multivariate data analysis (MVA) reveals that ethyl acetate and
ethanol extracts were well separated from the aqueous extract by PC1 while being
well separated from each other by PC2. The same observations were seen
with chloroform and 50% ethanol extracts. In contrast, the chemical shift signals
for hexane extract clusters in-between that of chloroform and 50% ethanol, indicated
that they have similar chemical profiles. Using partial least square discriminative
analysis (PLS-DA), compounds responsible for the group separation were
identified from the loading plot. Detailed examination of the loading plot shows
that ethanol and ethyl acetate extracts contain significantly higher amounts of
carotenoids, amino acids, vitamins and fatty acids. A total of 35 compounds were
detected from the 6 different solvents upon which the ethanolic and ethyl acetate
extracts were identified to contain more metabolites and in a wider range than
the other organic solvent extracts.

Results:
Hence, these two extracts would be more appropriate in metabolite extraction
for analysis and for medicinal purposes. Therefore, NMR spectroscopy,
in compliment with the right choice of solvent for extraction, could be utilized
by relevant industries to evaluate and obtain maximum important metabolites in
a shorter time.

Conclusion:
In addition to possession of high diverse metabolites, the microalgae
C. vulgaris could serve as an important functional food ingredient in the
aquaculture industry and may possibly be considered as a source of biofuel.
Effectiveness of Combining Organizational Alcohol Policy and Skills Training for Managers to Reduce Hazardous Alcohol Consumption in Swedish Workplaces: Study Protocol for a Cluster Randomized Study
Authors: Elling Devy Lysandra , Wilson Martina , Carlbring Per , Wennberg Peter , Sundqvist Kristina 
Published: August 2020

Background
High alcohol consumption poses risks to individual health and society. Previous alcohol interventions have mainly focused on high-risk consumers or young adults in school-based settings. Since the majority of the adult population is in the workforce, the workplace can be considered a favorable arena for implementing interventions.

Objective
This protocol describes a project aimed at increasing knowledge of the effectiveness of combining the implementation of an organizational alcohol policy with skills training for managers as a workplace alcohol prevention program, by evaluating the intervention and exploring managers’ perceptions of the intervention.

Methods
Organizations with at least 100 employees were invited to take part in the project. A total of 11 organizations (744 managers and 11,761 employees) were included in the project. Data are collected through self-administered online surveys at baseline, 12 months, and 24 months. The primary outcome is managers’ inclination to initiate an early alcohol intervention (eg, by initiating a dialogue) when concern regarding employees’ hazardous alcohol consumption arises. The secondary outcomes of interest are managers’ and employees’ organizational alcohol policy knowledge and changes in alcohol consumption, as measured using the Alcohol Use Disorder Identification Test (AUDIT) score. A linear mixed-model framework will be used to model variability on different levels. Primary analysis will follow an intention-to-treat approach. Additionally, managers’ responses from semistructured interviews will be analyzed using thematic analysis to explore managers’ experiences regarding the prevention program.

Results
This study is ongoing. The overall study start was on January 2018, and the study is planned to end in December 2020. Baseline and 12-month follow-up measurements have been collected.

Conclusions
This project is designed to evaluate the effectiveness of an alcohol prevention program regarding higher inclination to initiate early alcohol interventions after policy implementation and skills training among managers, compared to the usual practices in the workplace. The results from this study can contribute to increased knowledge about alcohol interventions and future prevention programs in the workplace.

Trial Registration
ISRCTN17250048; http://www.isrctn.com/ISRCTN17250048

International Registered Report Identifier (IRRID)
DERR1-10.2196/17145