bluuebunny/crossref_metadata_2025_split huggingface dataset:
The application of jBatik software for batik products
Authors: Nurjanah I , Abdullah A G , Widiaty I 
Published: May 2020

Abstract
Batik is one of Indonesia’s cultural heritage that must be preserved. jBatik is an application that introduces the process of making batik motif designs using technology. The purpose of this study is to apply the technology for making batik motif designs in the batik industry. the use of technology in batik designs is expected to facilitate the making of motif designs and provide more creative quality craftsmen. and can prepare for industry challenges of the 4.0 era. The technology used is jBatik is an application to make batik motifs with fractal principles. The paper writing method is in the form of jBatik application analysis which is already available on the internet. this finding shows that the process of making batik motif designs using jBatik application is faster and more effective by producing two types of motifs namely 2D and 3D motifs depending on the parameters used. The use of jBatik application is practical and facilitated by various variations of batik motifs.
Geographic information system in education
Authors: Dewa P , Mulyanti B , Widiaty I 
Published: May 2020

Abstract
The purpose of the study this is to know how to work Geographical Information System (GIS) which can in be applied in educational vocation. The method of writing a paper is done through a literature study. The author analyzed 30 papers from the years 2014 to 2019 on the role of GIS in education vocational. Search results illustrate that GIS is a system of information-based computer that combines the elements of the map (geographically) and the data on the map of the (data attribute) that is designed to insert, processing, analyzing and displaying the data spatially are referencing the condition of the earth. The role of GIS is very reliable in helping the activities of learning are related to aspects of spatial.
Internet of things application in mechanical learning in automotive engineering
Authors: Kurnia R , Mulyanti B , Widiaty I 
Published: May 2020

Abstract
Internet of Things (IoT) is a technology that uses an internet network that allows control and communication between many objects. The purpose of this paper is to determine the advantages and disadvantages of using the current Internet of Things (IoT) technology and the development of the IoT concept in the automotive field. The method used is a systematic literature review by reviewing journals that discuss IoT-based digital learning media in the automotive field from 2014 to 2019. The results show that IoT-based digital learning media can be used easily in automotive engineering education as a reference for researchers about the application of instructional media engaged in automotive engineering education.
CIPP evaluation learning development model in vocational laboratories based on ISO 9001: 2008
Authors: Mukhidin M , Kustiawan I , Suartini T , Hasan B , Sukandar A 
Published: May 2020

Abstract
The purpose of this study is to evaluate the learning process in vocational high school laboratory certified ISO 9001:2008 using CIPP (Context Input Process Product) learning model. We conducted the combination of quantitative and qualitative research method in vocational high schools, West Java area. The instruments for collecting data consist of paper test, observations and discussions with the principals, teachers, students, and industrial representatives. The results showed that learning model is very appropriate because of fulfilling ISO requirements, that is, standards for input, process, product, infrastructure, and evaluation. This model can be used as a learning model by teachers in vocational high school laboratories.
Direct-acting oral anticoagulant use at extremes of body weight: Literature review and recommendations
Authors: Covert Kelly , Branam Donald L 
Published: May 2020

Abstract

Purpose
To review the literature on treatment of venous thromboembolism (VTE) and prevention of cardioembolic stroke with direct-acting oral anticoagulants (DOACs) in low- and high-body-weight patients and to make recommendations regarding agent selection and dosing in these patient populations.

Summary
The selection and optimal dosing of DOACs in low- and high-body-weight patients has not yet been fully elucidated by clinical trials; however, evidence suggests that issues of both safety and efficacy in patients at the extremes of body weight may warrant careful consideration when selecting a DOAC for such patients. This review provides a thorough discussion of the use of DOACs in the treatment of VTE and prevention of cardioembolic stroke in patients at the extremes of body weight and provides guidance regarding agent selection.

Conclusion
While the published evidence on use of DOACs in patients at extremes of body weight is sparse, apixaban and rivaroxaban appear to have the most favorable safety and efficacy profiles. Edoxaban and dabigatran should be avoided.
MiRACLe: an individual-specific approach to improve microRNA-target prediction based on a random contact model
Authors: Wang Pan , Li Qi , Sun Nan , Gao Yibo , Liu Jun S , Deng Ke , He Jie 
Published: May 2020

AbstractDeciphering microRNA (miRNA) targets is important for understanding the function of miRNAs as well as miRNA-based diagnostics and therapeutics. Given the highly cell-specific nature of miRNA regulation, recent computational approaches typically exploit expression data to identify the most physiologically relevant target messenger RNAs (mRNAs). Although effective, those methods usually require a large sample size to infer miRNA–mRNA interactions, thus limiting their applications in personalized medicine. In this study, we developed a novel miRNA target prediction algorithm called miRACLe (miRNA Analysis by a Contact modeL). It integrates sequence characteristics and RNA expression profiles into a random contact model, and determines the target preferences by relative probability of effective contacts in an individual-specific manner. Evaluation by a variety of measures shows that fitting TargetScan, a frequently used prediction tool, into the framework of miRACLe can improve its predictive power with a significant margin and consistently outperform other state-of-the-art methods in prediction accuracy, regulatory potential and biological relevance. Notably, the superiority of miRACLe is robust to various biological contexts, types of expression data and validation datasets, and the computation process is fast and efficient. Additionally, we show that the model can be readily applied to other sequence-based algorithms to improve their predictive power, such as DIANA-microT-CDS, miRanda-mirSVR and MirTarget4. MiRACLe is publicly available at https://github.com/PANWANG2014/miRACLe.
Gene analysis of major signaling pathways regulated by gonadotropins in human ovarian granulosa tumor cells (KGN)†
Authors: Tremblay Patricia G , Sirard Marc-André 
Published: May 2020

AbstractThe female reproductive function largely depends on timing and coordination between follicle-stimulating hormone (FSH) and luteinizing hormone. Even though it was suggested that these hormones act on granulosa cells via shared signaling pathways, mainly protein kinases A, B, and C (PKA, PKB, and PKC), there is still very little information available on how these signaling pathways are regulated by each hormone to provide such differences in gene expression throughout folliculogenesis. To obtain a global picture of the principal upstream factors involved in PKA, PKB, and PKC signaling in granulosa cells, human granulosa-like tumor cells (KGN) were treated with FSH or specific activators (forskolin, SC79, and phorbol 12-myristate 13-acetate) for each pathway to analyze gene expression with RNA-seq technology. Normalization and cutoffs (FC 1.5, P ≤ 0.05) revealed 3864 differentially expressed genes between treatments. Analysis of major upstream regulators showed that PKA is a master kinase of early cell differentiation as its activation resulted in the gene expression profile that accompanies granulosa cell differentiation. Our data also revealed that the activation of PKC in granulosa cells is also a strong differentiation signal that could control “advanced” differentiation in granulosa cells and the inflammatory cascade that occurs in the dominant follicle. According to our results, PKB activation provides support for PKA-stimulated gene expression and is also involved in granulosa cell survival throughout follicular development. Taken together, our results provide new information on PKA, PKB, and PKC signaling pathways and their roles in stimulating a follicle at the crossroad between maturation/ovulation and atresia.
Evaluating the granularity and statistical structure of lesions and behaviour in post-stroke aphasia
Authors: Zhao Ying , Halai Ajay D , Lambon Ralph Matthew A 
Published: May 2020

AbstractThe pursuit of relating the location of neural damage to the pattern of acquired language and general cognitive deficits post-stroke stems back to the 19th century behavioural neurology. While spatial specificity has improved dramatically over time, from the large areas of damage specified by post-mortem investigation to the millimetre precision of modern MRI, there is an underlying issue that is rarely addressed, which relates to the fact that damage to a given area of the brain is not random but constrained by the brain’s vasculature. Accordingly, the aim of this study was to uncover the statistical structure underlying the lesion profile in chronic aphasia post-stroke. By applying varimax-rotated principal component analysis to the lesions of 70 patients with chronic post-stroke aphasia, we identified 17 interpretable clusters, largely reflecting the vascular supply of middle cerebral artery sub-branches and other sources of individual variation in vascular supply as shown in classical angiography studies. This vascular parcellation produced smaller displacement error in simulated lesion–symptom analysis compared with individual voxels and Brodmann regions. A second principal component analysis of the patients’ detailed neuropsychological data revealed a four-factor solution reflecting phonological, semantic, executive-demand and speech fluency abilities. As a preliminary exploration, stepwise regression was used to relate behavioural factor scores to the lesion principal components. Phonological ability was related to two components, which covered the posterior temporal region including the posterior segment of the arcuate fasciculus, and the inferior frontal gyrus. Three components were linked to semantic ability and were located in the white matter underlying the anterior temporal lobe, the supramarginal gyrus and angular gyrus. Executive-demand related to two components covering the dorsal edge of the middle cerebral artery territory, while speech fluency was linked to two components that were located in the middle frontal gyrus, precentral gyrus and subcortical regions (putamen and thalamus). Future studies can explore in formal terms the utility of these principal component analysis-derived lesion components for relating post-stroke lesions and symptoms.
On the time-course of functional connectivity: theory of a dynamic progression of concussion effects
Authors: Boshra Rober , Ruiter Kyle I , Dhindsa Kiret , Sonnadara Ranil , Reilly James P , Connolly John F 
Published: May 2020

AbstractThe current literature presents a discordant view of mild traumatic brain injury and its effects on the human brain. This dissonance has often been attributed to heterogeneities in study populations, aetiology, acuteness, experimental paradigms and/or testing modalities. To investigate the progression of mild traumatic brain injury in the human brain, the present study employed data from 93 subjects (48 healthy controls) representing both acute and chronic stages of mild traumatic brain injury. The effects of concussion across different stages of injury were measured using two metrics of functional connectivity in segments of electroencephalography time-locked to an active oddball task. Coherence and weighted phase-lag index were calculated separately for individual frequency bands (delta, theta, alpha and beta) to measure the functional connectivity between six electrode clusters distributed from frontal to parietal regions across both hemispheres. Results show an increase in functional connectivity in the acute stage after mild traumatic brain injury, contrasted with significantly reduced functional connectivity in chronic stages of injury. This finding indicates a non-linear time-dependent effect of injury. To understand this pattern of changing functional connectivity in relation to prior evidence, we propose a new model of the time-course of the effects of mild traumatic brain injury on the brain that brings together research from multiple neuroimaging modalities and unifies the various lines of evidence that at first appear to be in conflict.
The combined novel KCNQ1 frameshift I145Sfs*92 and nonsense W392X variants caused Jervell and Lange-Nielsen syndrome in a Chinese infant presenting with sustained foetal bradycardia
Authors: Zhang Yanmin , Li Xiaomin , Yang Ying , Wang Jie , Gao Xinru , Fan Mengyun 
Published: May 2020

Abstract

Aims
We report clinical and molecular analysis of an infant presenting with foetal bradycardia and clinical outcome of Jervell and Lange-Nielsen syndrome (JLNS).

Methods and results
Clinical, electrocardiogram (ECG), and echocardiographic data were collected from members in a three-generation family. Whole exomes were amplified and sequenced for proband. The identified variants were verified in the remaining members. The pathogenicity of candidate variants was predicted using multiple software programmes. A 28-year-old non-consanguineous Chinese woman at 23 weeks’ gestation presenting with sustained foetal bradycardia of 100 b.p.m. Immunological disorders and infection were excluded. The infant was delivered at 37 weeks’ gestation with 2700-g birthweight. QTc was prolonged in both ECG and Holter recording. Hearing tests confirmed bilateral sensorineural hearing loss. Genetic testing demonstrated that the infant carried a novel frameshift c.431delC (p.I145Sfs*92) and a novel nonsense c.1175G&gt;A (p.W392X) compound variants of KCNQ1 inherited from mother and father, respectively, in autosomal recessive inheritance. Only relative II-5 carrying heterozygous KCNQ1-I145Sfs*92 variant had prolonged QTc, while the other carriers did not have prolonged QT, suggesting an autosomal dominant inheritance of LQT1 phenotype with incomplete penetrance in the family.

Conclusion
We report the novel frameshift KCNQ1-I145Sfs*92 and nonsense KCNQ1-W392X compound variants in autosomal recessive inheritance that caused JLNS presenting as sustained foetal bradycardia for the first time. Meanwhile, KCNQ1-I145Sfs*92 heterozygous variant demonstrated LQT1 phenotype in autosomal dominant inheritance with incomplete penetrance.
Early Signs of Gut Microbiome Aging: Biomarkers of Inflammation, Metabolism, and Macromolecular Damage in Young Adulthood
Authors: Renson Audrey , Mullan Harris Kathleen , Dowd Jennifer B , Gaydosh Lauren , McQueen Matthew B , Krauter Kenneth S , Shannahan Michael , Aiello Allison E 
Published: May 2020

Abstract
Emerging links between gut microbiota and diseases of aging point to possible shared immune, metabolic, and cellular damage mechanisms, operating long before diseases manifest. We conducted 16S rRNA sequencing of fecal samples collected from a subsample (n = 668) of Add Health Wave V, a nationally representative longitudinal study of adults aged 32–42. An overlapping subsample (n = 345) included whole-blood RNA-seq. We examined associations between fecal taxonomic abundances and dried blood spot-based markers of lipid and glucose homeostasis and C-reactive protein (measured in Wave IV), as well as gene expression markers of inflammation, cellular damage, immune cell composition, and transcriptomic age (measured in Wave V), using Bayesian hierarchical models adjusted for potential confounders. We additionally estimated a co-abundance network between inflammation-related genes and bacterial taxa using penalized Gaussian graphical models. Strong and consistent microbiota associations emerged for HbA1c, glucose, C-reactive protein, and principal components of genes upregulated in inflammation, DNA repair, and reactive oxygen species, with Streptococcus infantis, Pseudomonas spp., and Peptoniphilus as major players for each. This pattern was largely echoed (though attenuated) for immunological cell composition gene sets, and only Serratia varied meaningfully by transcriptomic age. Network co-abundance indicated relationships between Prevotella sp., Bacteroides sp., and Ruminococcus sp. and gut immune/metabolic regulatory activity, and Ruminococcus sp, Dialister, and Butyrivibrio crossotus with balance between Th1 and Th2 inflammation. In conclusion, many common associations between microbiota and major physiologic aging mechanisms are evident in early-mid adulthood and suggest avenues for early detection and prevention of accelerated aging.
What happens when performance-based financing meets free healthcare? Evidence from an interrupted time-series analysis
Authors: Kuunibe Naasegnibe , Lohmann Julia , Hillebrecht Michael , Nguyen Hoa Thi , Tougri Gauthier , De Allegri Manuela 
Published: May 2020

Abstract
In spite of the wide attention performance-based financing (PBF) has received over the past decade, no evidence is available on its impacts on quantity and mix of service provision nor on its interaction with parallel health financing interventions. Our study aimed to examine the PBF impact on quantity and mix of service provision in Burkina Faso, while accounting for the parallel introduction of a free healthcare policy. We used Health Management Information System data from 838 primary-level health facilities across 24 districts and relied on an interrupted time-series analysis with independent controls. We placed two interruptions, one to account for PBF and one to account for the free healthcare policy. In the period before the free healthcare policy, PBF produced significant but modest increases across a wide range of maternal and child services, but a significant decrease in child immunization coverage. In the period after the introduction of the free healthcare policy, PBF did not affect service provision in intervention compared with control facilities, possibly indicating a saturation effect. Our findings indicate that PBF can produce modest increases in service provision, without altering the overall service mix. Our findings, however, also indicate that the introduction of other health financing reforms can quickly crowd out the effects produced by PBF. Further qualitative research is required to understand what factors allow healthcare providers to increase the provision of some, but not all services and how they react to the joint implementation of PBF and free health care.
Colleagues as friends
Authors: Popper Arthur N 
Published: May 2020

AbstractCollaboration is integral to most scientific research today, and it has certainly been important in my career and for my career path. However, not all collaborations are “equal”. Most, in fact, are short term or transient, with collaborators working on one project and then moving on to other projects and perhaps other collaborations. There are, however, a few collaborations, such as the three I describe here, that are long term and that not only resulted in a large number of collaborative projects but that also strongly influenced career paths. Indeed, these three collaborations resulted in all of us undertaking new paths that we were not likely to have taken alone or without the stimulation of working with someone we know well and have learned to trust.
Performance investigation of a micro-channel flat separated loop heat pipe system for data centre cooling
Authors: Hu Menglong , Luo Liang , Badiei Ali , Chen Fucheng , Zheng Siming , Wang Zhangyuan , Zhao Xudong 
Published: May 2020

Abstract
This paper investigates a novel micro-channel flat separated loop heat pipe system for cooling the information technology equipment in the data centres through theoretical and experimental analysis and by assessing the impact of the inlet water temperature on system performance. A computer model is developed to simulate the steady-state performance of the micro-channel flat separated loop heat pipe system. After comparing the experimental and modelling results, the new and conventional system under the same working conditions, the model is validated yielding high accuracy in predicting the performance of the micro-channel flat separated loop heat pipe system with recorded error being limited to 2.16–8.97%. The new system has better performance than the conventional system. Under the operating conditions of heat load intensity of 1,000 W/m2, water flow rate of 0.28 m3/h, refrigerant filling rate of 30%, ambient air temperature of 26°C, and evaporator and condenser height difference of 0.8 m, the performance of the system has been explored at inlet temperature from 15 to 24°C with increments of 3°C. The system’s averaged heat transfer efficiency was found to decrease with the increase in inlet temperature. This research provides valuable insight into the data centre information technology equipment cooling, which is of great significance for energy saving and environmentally friendly operation of data centres.
Energy Reserve Compensating for Trade-Off Between Metabolic Resistance and Life History Traits in the Brown Planthopper (Hemiptera: Delphacidae)
Authors: Fujii Tomohisa , Sanada-Morimura Sachiyo , Matsukura Keiichiro , Van Chien Ho , Cuong Le Quoc , Loc Phung Minh , Estoy Gerardo F , Matsumura Masaya 
Published: May 2020

AbstractDevelopment of insecticide resistance often changes life history traits of insect pests, because metabolic detoxification of insecticides in insect bodies requires huge energetic reserves. The brown planthopper, Nilaparvata lugens (Stål), an important insect pest of rice crop in East and Southeast Asia, has developed strong resistance to imidacloprid from mid-2000s. The aim of this study was to examine the costs of life history traits and reveal changes in energy reserves with developing imidacloprid resistance. We compared the life history traits (survival time, fecundity, developmental time, and hatchability) and total lipid content between imidacloprid-resistant and imidacloprid-susceptible (control) brown planthopper strains. As compared to the control strains, adults’ survival time of the resistant females was shorter, and their fecundity was lower; the other life history traits did not differ significantly between the resistant and control strains. As the results, net reproductive rates (R0) were lower in the resistant strains than in the susceptible strains. However, the amount of stored lipids was larger in resistant females than control ones. Our findings demonstrated a physiological trade-off between the development of imidacloprid resistance and the reproductive traits of brown planthopper. The imidacloprid-resistant strains are likely to store lipids for metabolic detoxification rather than consume them for reproduction.