bluuebunny/crossref_metadata_2025_split huggingface dataset:
AT 2020iko: A WZ Sge-type Dwarf Nova Candidate with an Anomalous Precursor Event
Authors: Soraisam Monika D. , DeSantis Sarah R. , Lee Chien-Hsiu , Matheson Thomas , Narayan Gautham , Saha Abhijit , Sand David J. , Stubens Carl , Szkody Paula , Wolf Nicholas , Wyatt Samuel D. , Hosokawa Ryohei , Kawai Nobuyuki , Murata Katsuhiro L. 
Published: December 2020

Abstract
The ongoing Zwicky Transient Facility (ZTF) survey is generating a massive alert rate from a variety of optical transients and variable stars, which are being filtered down to subsets meeting user-specified criteria by broker systems such as the Arizona-NOIRLab Temporal Analysis and Response to Events System (ANTARES). In a beta implementation of the algorithm of Soraisam et al. on ANTARES, we flagged AT 2020iko from the ZTF real-time alert stream as an anomalous source. This source is located close to a red extended Sloan Digital Sky Survey source. In the first few epochs of detection, it exhibited a V-shaped brightness profile, preceded by nondetections both in ZTF and in the All-Sky Automated Survey for Supernovae extending to 2014. Its full light curve shows a precursor event, followed by a main superoutburst and at least two rebrightenings. A low-resolution spectrum of this source points to a dwarf nova (DN) nature. Although some of the features of AT 2020iko indicate an SU UMa-type DN, its large amplitude, presence of rebrightenings, and inferred supercycle period of ≥6 yr are in favor of AT 2020iko being a new WZ Sge-type DN candidate, a subset of rare DNe consisting of extreme mass-ratio (<0.1) binaries with an orbital period around the period minimum. The precusor event of AT 2020iko brightened by 6.5 mag, while its decay spanned 3–5 mag. We speculate this superoutburst is associated with a less expanded accretion disk than in typical superoutbursts in WZ Sge systems, with the large depth of the precursor decay implying an extremely small mass ratio. To the best of our knowledge, such a precursor event has not been recorded for any DN. This result serves to demonstrate the efficacy of our real-time anomaly search algorithm.
YZiCS: On the Mass Segregation of Galaxies in Clusters
Authors: Kim Seonwoo , Contini Emanuele , Choi Hoseung , Han San , Lee Jaehyun , Oh Sree , Kang Xi , Yi Sukyoung K. 
Published: December 2020

Abstract
Mass segregation, a tendency for more massive galaxies to be distributed closer to the cluster center, is naturally expected from dynamical friction, but its presence is still controversial. Using deep optical observations of 14 Abell clusters (KYDISC) and a set of hydrodynamic simulations (YZiCS), we find in some cases a hint of mass segregation inside the virial radius. Segregation is visible more clearly when the massive galaxy fraction is used instead of mean stellar mass. The trend is more significant in the simulations than in the observations. To find out the mechanisms affecting mass segregation, we look into the evolution of individual simulated clusters. We find that the degree of mass segregation is different for different clusters: the trend is visible only for low-mass clusters. We compare the masses of galaxies and their dark halos at the time of infall and at the present epoch to quantify the amount of tidal stripping. We then conclude that satellites that get accreted at earlier epochs, or galaxies in more massive clusters, go through more tidal stripping. These combined effects result in a correlation between the host halo mass and the degree of stellar mass segregation.
Structure of Quark Star: A Comparative Analysis of Bayesian Inference and Neural Network Based Modeling
Authors: Traversi Silvia , Char Prasanta 
Published: December 2020

Abstract
In this work, we compare two powerful parameter estimation methods, namely Bayesian inference and neural network based learning, to study the quark matter equation of state with constant speed of sound parameterization and the structure of the quark stars within the two-family scenario. We use the mass and radius estimations from several X-ray sources and also the mass and tidal deformability measurements from gravitational wave events to constrain the parameters of our model. The results found from the two methods are consistent. The predicted speed of sound is compatible with the conformal limit.
Near-infrared and Optical Continuum Emission Region Size Measurements in the Gravitationally lensed Quasars Q0957+561 and SBS0909+532
Authors: Cornachione Matthew A. , Morgan Christopher W. , Burger Hayden R. , Shalyapin Vyacheslav N. , Goicoechea Luis J. , Vrba Frederick J. , Dahm Scott E. , Tilleman Trudy M. 
Published: December 2020

Abstract
We present a microlensing analysis of updated light curves in three filters, the g-band, r-band, and H-band, for the gravitationally lensed quasars Q0957+561 and SBS0909+532. Both systems display prominent microlensing features which we analyze using our Bayesian Monte Carlo technique to constrain the quasar continuum emission region sizes in each band. We report sizes as half-light radii scaled to a 60° inclination angle. For Q0957+561 we measure

,

, and

in g-, r-, and H-band, respectively. For SBS0909+532 we measure

,

, and

in the g-, r-, and H-band respectively. With size measurements in three bands spanning the quasar rest frame ultraviolet to optical, we can place constraints on the scaling of accretion disk size with wavelength,

. In a joint analysis of both systems we find a slope shallower than that predicted by thin disk theory,

, consistent with other constraints from multi-epoch microlensing studies.
Espaces fictionnels, espaces interactionnels : approches linguistiques des séries
Authors: Debras Camille 
Published: December 2020

Les séries plaisent-elles parce que les personnages parlent comme le spectateur, reflétant ainsi son univers ? Cet article propose un tour d’horizon des approches linguistiques des séries, autour de la notion centrale d’espace. Deux approches se sont particulièrement saisies des séries, la linguistique de corpus et la linguistique interactionnelle, autour de trois enjeux centraux : la représentation du réel, la définition des personnages et l’interaction avec le spectateur. À partir d’analyses semi-automatisées de transcriptions des dialogues des séries, la linguistique de corpus en caractérise le genre discursif. La linguistique interactionnelle théorise l’enchâssement des deux espaces d’interaction mis en jeu : l’interaction réelle entre le spectateur et la série, qui se construit par le biais de l’interaction fictionnelle entre les personnages.Comme le montrent Quaglio et Bednarek, le genre discursif de la série est plus informel, plus émotionnel, moins vague, et moins narratif que la conversation spontanée. La stabilité langagière des personnages au fil des saisons est centrale pour construire la stabilité de l’univers fictionnel. Les pratiques langagières et sémiotiques des personnages mettent en jeu les attentes et les cadres interprétatifs socioculturels du spectateur pour construire des types.L’espace interactionnel spectateur-fiction a donné lieu à de multiples théorisations ; le modèle d’interaction screen-to-face proposé par Bubel est le plus abouti. Celui-ci intègre les notions de participation framework proposée par Goffman et Clark, celle de recipient design proposée par Sacks et ses collègues, ainsi que les travaux anthropologiques de Duranti sur le rôle actif du spectateur. Toolan montre que l’opacité linguistique dans une série comme The Wire est sa force, car la série joue sur le dispositif d’interaction screen-to-face, en positionnant un spectateur en proie à de constantes difficultés de compréhension aux côtés de personnages qui ne cessent de s’épier.
Atlanta (FX, Donald Glover, 2016-), vers une transgression générique des frontières géographiques et sociales
Authors: Ducotey Yvelin 
Published: December 2020

« Le paysage a beau être dégagé et le terrain visible, l’espace cache beaucoup plus de choses qu’il ne révèle ». Donald Glover, artiste polyvalent (musicien, acteur, réalisateur, producteur) illustre ce constat dans la série qu’il dirige, Atlanta (FX, 2016-) et ce dès la séquence introductive du premier épisode. Après une rapide plongée dans le milieu du rap à Atlanta, une succession de plans aériens en plongées verticales « cartographie » la ville d’Atlanta et présente au spectateur plusieurs frontières qui s’avèrent identitaires. L’ouverture de la série dévoile un tissu urbain fait de disparités, entre résidences familiales aisées et quartiers défavorisés où les terrains vagues se multiplient. Les coupes franches entre ces différentes réalités spatiales semblent rendre le dialogue entre elles impossible. Néanmoins, le paysage est « dégagé », mais derrière la verticalité des plans se dissimule une réalité sociale complexe et normée que le showrunner Donald Glover décortique d’épisode en épisode. Après avoir mis en scène les interstices spatiaux qui deviennent des zones de tension, Donald Glover répond aux frontières qui se dressent devant ses personnages par une hybridité générique et une liberté créatrice remarquable lui permettant de s’extirper du cadre, tant formel que sociétal.
Integration of the Transcriptome and Genome-Wide Landscape of BRD2 and BRD4 Binding Motifs Identifies Key Superenhancer Genes and Reveals the Mechanism of Bet Inhibitor Action in Rheumatoid Arthritis Synovial Fibroblasts
Authors: Krishna Vinod , Yin Xuefeng , Song Qingxuan , Walsh Alice , Pocalyko David , Bachman Kurtis , Anderson Ian , Madakamutil Loui , Nagpal Sunil 
Published: December 2020

Abstract
Fibroblast-like synoviocytes (FLS), one of the main cell types of the rheumatoid arthritis (RA) synovium, possess phenotypic and molecular characteristics of transformed cells. JQ1, an inhibitor of the bromodomain and extra terminal domain family that includes BRD2, BRD3, BRD4, and BRDt, has shown efficacy in models of arthritis. We demonstrate that the active isomer of JQ1 but not its inactive isomer inhibits IL-1β–induced RA-FLS activation and proliferation. To understand the mechanism of JQ1 action, we subjected JQ1-treated RA-FLS to transcriptional profiling and determined BRD2 and BRD4 cistromes by identifying their global chromatin binding sites. In addition, assay for transposable accessible chromatin by high throughput sequencing was employed to identify open and closed regions of chromatin in JQ1-treated RA-FLS. Through an integrated analysis of expression profiling, Brd2/Brd4 cistrome data, and changes in chromatin accessibility, we found that JQ1 inhibited key BRD2/BRD4 superenhancer genes, downregulated multiple crucial inflammatory pathways, and altered the genome-wide occupancy of critical transcription factors involved in inflammatory signaling. Our results suggest a pleiotropic effect of JQ1 on pathways that have shown to be individually efficacious in RA (in vitro, in vivo, and/or in humans) and provide a strong rationale for targeting BRD2/BRD4 for disease treatment and interception.
SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment
Authors: O’Connell Patrick , Hyslop Sean , Blake Maja K , Godbehere Sarah , Amalfitano Andrea , Aldhamen Yasser A 
Published: December 2020

Abstract
T cell exhaustion represents one of the most pervasive strategies tumors employ to circumvent the immune system. Although repetitive, cognate TCR signaling is recognized as the primary driving force behind this phenomenon, and it remains unknown what other forces drive T cell exhaustion in the tumor microenvironment (TME). In this study, we show that activation of the self-ligand SLAMF7 immune receptor on T cells induced STAT1 and STAT3 phosphorylation, expression of multiple inhibitory receptors, and transcription factors associated with T cell exhaustion. Analysis of The Cancer Genome Atlas revealed that SLAMF7 transcript levels were strongly correlated with various inhibitory receptors and that high SLAMF7 expression was indicative of poor survival in clear cell renal cell carcinoma (ccRCC). Targeted reanalysis of a CyTOF dataset, which profiled the TME in 73 ccRCC patients, revealed cell-type–specific SLAMF7 expression patterns, strong correlations between exhausted T cells and SLAMF7+ tumor-associated macrophages (TAMs), and a unique subset of SLAMF7highCD38high TAMs. These SLAMF7highCD38high TAMs showed the strongest correlations with exhausted T cells and were an independent prognostic factor in ccRCC. Confirmatory ex vivo coculture studies validated that SLAMF7–SLAMF7 interactions between murine TAMs and CD8+ T cells induce expression of multiple inhibitory receptors. Finally, mice lacking SLAMF7 show restricted growth of B16-F10 tumors, and CD8+ T cells from these mice express less PD-1 and TOX and exhibited an impaired ability to progress through the exhaustion developmental trajectory to terminal exhaustion. These findings suggest that SLAMF7 might play an important role in modulating T cell function in the TME.
Granzyme B Induces IRF-3 Phosphorylation through a Perforin-Independent Proteolysis-Dependent Signaling Cascade without Inducing Cell Death
Authors: Gapud Eric J , Trejo-Zambrano Maria Isabel , Gomez-Banuelos Eduardo , Tiniakou Eleni , Antiochos Brendan , Granville David J , Andrade Felipe , Casciola-Rosen Livia , Rosen Antony 
Published: December 2020

Abstract
Granzyme B (GrB) is an immune protease implicated in the pathogenesis of several human diseases. In the current model of GrB activity, perforin determines whether the downstream actions of GrB occur intracellularly or extracellularly, producing apoptotic cytotoxicity or nonapoptotic effects, respectively. In the current study, we demonstrate the existence of a broad range of GrB-dependent signaling activities that 1) do not require perforin, 2) occur intracellularly, and 3) for which cell death is not the dominant outcome. In the absence of perforin, we show that GrB enzymatic activity still induces substoichiometric activation of caspases, which through nonlethal DNA damage response signals then leads to activity-associated phosphorylation of IFN regulatory factor–3. These findings illustrate an unexpected potential interface between GrB and innate immunity separate from the traditional role of GrB in perforin-dependent GrB-mediated apoptosis that could have mechanistic implications for human disease.
Cutting Edge: NOX2 NADPH Oxidase Controls Infection by an Intracellular Bacterial Pathogen through Limiting the Type 1 IFN Response
Authors: Rojas Márquez Jorge David , Li Taoyingnan , McCluggage Adam R R , Tan Joel M J , Muise Aleixo , Higgins Darren E , Brumell John H 
Published: December 2020

Abstract
The NOX2 NADPH oxidase (NOX2) produces reactive oxygen species to kill phagosome-confined bacteria. However, we previously showed that Listeria monocytogenes is able to avoid the NOX2 activity in phagosomes and escape to the cytosol. Thus, despite the established role of NOX2 limiting L. monocytogenes infection in mice, the underlying mechanisms of this antibacterial activity remain unclear. In this article, we report that NOX2 controls systemic L. monocytogenes spread through modulation of the type I IFN response, which is known to be exploited by L. monocytogenes during infection. NOX2 deficiency results in increased expression of IFN-stimulated genes in response to type I IFN and leads to 1) promotion of cell-to-cell spread by L. monocytogenes, 2) defective leukocyte recruitment to infection foci, and 3) production of anti-inflammatory effectors IL-10 and thioredoxin 1. Our findings report a novel antimicrobial role for NOX2 through modulation of type I IFN responses to control bacterial dissemination.
Renormalization and Siegel disks for complex Hénon maps
Authors: Gaidashev Denis , Radu Remus , Yampolsky Michael 
Published: December 2020

We use hyperbolicity of golden-mean renormalization of dissipative Hénon-like maps to prove that the boundaries of Siegel disks of sufficiently dissipative quadratic complex Hénon maps with golden-mean rotation number are topological circles.
Conditionally on an appropriate renormalization hyperbolicity property, we derive the same result for Siegel disks of Hénon maps with all eventually periodic rotation numbers.
Evaluasi Rekayasa Lalu Lintas Simpang Empat Bundaran Bersinyal Tugu Wisnu Surakarta
Authors: Evitmalasari Meilana , Sasmito Agus , Rokhim Abdul 
Published: December 2020

Salah satu upaya peningkatan keselamatan jalan ialah dengan mengurangi risiko terjadinya kecelakaan di simpang dengan cara mengoptimalkan kinerja simpang serta menurunkan jumlah konflik lalu lintas yang terjadi. Berdasarkan hal tersebut penulis melakukan penelitian upaya peningkatan keselamatan dengan cara penanganan konflik lalu lintas dan mengoptimalkan kinerja simpang. Penelitian ini bertujuan untuk memberikan penanganan simpang yang dapat diterapkan pada simpang empat Tugu Wisnu guna mewujudkan peningkatan keselamatan. Permasalahan pada simpang ini adalah terdapat ekor tundaan lalu lintas yang tertinggal pada bundaran sehingga menyebabkan konflik lalu lintas dengan arus lalu lintas pendekat simpang lainnya dengan fase APILL sama. Metode yang digunakan dalam analisis kinerja simpang menggunakan perhitungan MKJI dan disimulasikan menggunakan software Vissim 9 Full Version sedangkan metode untuk mengetahui konflik lalu lintas yang terjadi dengan menggunakan software SSAM. Kemudian memberikan usulan penanganan untuk diterapkan pada simpang empat Tugu Wisnu yaitu dengan perubahan pengaturan simpang 3 fase menjadi 4 fase dengan pergerakan lalu lintas mengelilingi bundaran serta 4 fase tanpa mengelilingi bundaran kemudian dari kedua usulan penanganan dipilih alternatif penanganan yang sesuai untuk menurunkan konflik lalu lintas dan mengoptimalkan kinerja simpang. Alternatif penanganan simpang yang dipilih berupa perubahan pengaturan simpang dengan 4 fase dengan pergerakan lalu lintas tanpa mengelilingi bundaran dapat menurunkan jumlah konflik lalu lintas sebesar 30% dan tingkat pelayanan simpang adalah D yang berarti terciptanya keselarasan antara keselamatan jalan dan kelancaran lalu lintas.
On The Norms of Another Form of $r-$Circulant Matrices with The Hyper-Fibonacci and Lucas Numbers
Authors: BAHŞİ Mustafa , SOLAK Süleyman 
Published: December 2020

In this paper, we compute the spectral norms of $r-$ circulant matrices with the hyper-Fibonacci and hyper-Lucas numbers of the forms $F_{r}=Circ-r(F_k^{(0)},F_k^{(1)},...,F_k^{(n-1)}) $, $L_r=Circ-r(L_{k}^{\left( 0\right) },L_{k}^{\left( 1\right) },...,L_{k}^{\left( n-1\right) })$ and their Hadamard and Kronecker products. For this, we firstly compute the spectral and Euclidean norms of circulant matrices of the forms $F=Circ(F_{k}^{\left( 0\right) }, F_{k}^{\left( 1\right) },... ,F_{k}^{\left( n-1\right) })$ and $L=Circ(L_{k}^{\left( 0\right) },L_{k}^{\left( 1\right) },...,L_{k}^{\left( n-1\right) })$. Moreover, we give some examples related to special cases of our results.
PREVENTION AND MANAGEMENT OF GUDAGATA VIKARA (ANORECTAL DISORDERS)- AYURVEDIC PERSPECTIVE
Authors: Borkar Sneha P  , Dongre Amol A  
Published: December 2020

Gudagata Vikara (Anorectal disorders) refers to ailments of the anus and/ or rectum. Gudagata Vikara includes; Arsha (Haemorrhoids), Bhagandara (Fistula in Ano), Parikartika (Fissure in Ano), Guda Kandu (Pruritus Ani), etc. These are some common disorders in human being. A study by Sharma et al. showed that Hemorrhoids (49%) and fistula-in-ano (27%) were commonest anorectal conditions, mostly affecting the age group 18-45 years. Apathya Ahara and Vihara leads to vitiation of Doshas causing Mandagni and vitiation of Apanavayu resulting in stagnation of Mala in Gudavali which leads to anorectal disorders. In present study a thorough and scientific review of Ahara (diet) and Vihara (lifestyle) has been carried out for the prevention and management of anorectal diseases. Materials and methods: Ayurvedic treaties, text books, Dissertation, Articles from PUBMED, SCOPUS, Google scholar, Mesh, Google search has been searched thoroughly related to the subject.
Discussion: Gudagata Vikara, Anorectal Disorders, Ahara (Diet), Vihara (Lifestyle), Dinacharya, Ritucharya, Sadvritta has been discussed.
Conclusions: Food articles mentioned in Ayurvedic text are effective in the management of Anorectal diseases. Lifestyle changes according to Dinacharya, Ritucharya and Sadavritta and following do’s and don’ts are effective in the management of Anorectal diseases
Corticosteroids in the treatment of SARS-CoV-2 related lung disease
Authors: Ivaschkin V. T. , Zolnikova O. Yu. , Svistunov A. A. , Dzhakhaya N. L. , Potskhverashvili N. D. , Kokina N. I. , Buklis E. R. , Roshchina T. V. , Komkova I. I. , Nadinskaia M. Yu. 
Published: December 2020

Aim. To explore the effectiveness of corticosteroids in patients with lung damage caused by SARS-CoV-2.Materials and methods. The retrospective study included patients with confirmed SARS-CoV-2 infection and lung damage diagnosed by computed tomography (CT), who was receiving low molecular weight heparin (LMWH). 56 patients included in Group 1 received dexamethasone 4–12 mg/day for 8–10 days after admission to the hospital. 30 patients included in Group 2 (control group) had no dexamethasone treatment. The laboratory and instrumental data obtained from the patients under admission and for the 8–10th day of the treatment were analyzed. Hospital mortality was evaluated by Kaplan — Meier method. To predict a lethal outcome, we have used the logistic regression method. Results. By the 8–10th day of hospitalization, only in the Group 1, there was a statistically significant decrease in the volume of lung tissue lesions by CT (p = 0.027), fibrinogen concentration (p = 0.001). A statistically significant decrease of the C-reactive protein concentration was noted for the both groups. Oxygen therapy was more often needed in Group 2 (26 patients — 87%) in opposite to Group 1 (36 patients — 64%) (p = 0.028). Hospital mortality was 3.6% in Group 1 and 13.3% in Group 2 (p = 0.177). There was a trend towards an increase in patient survival in Group 1 between 18 and 28 days of hospitalization (Mantel — Cox test, p = 0.095). Age (p = 0.012), percentage of CT lesions at the time of admission (p = 0.020) and assignment to the dexamethasone group (p = 0.080) were included in the logistic regression equation.Conclusion. For the patients with SARS-CoV-2 lung damage, treatment with dexamethasone 4–12 mg, started from the first day of hospitalization additionally to LMWH, contributes to positive CT dynamics on the 8–10th day and decreases hospital mortality.