bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell Tracking Profiler – a user-driven analysis framework for evaluating 4D live-cell imaging data
Authors: Mitchell Claire , Caroff Lauryanne , Solis-Lemus Jose Alonso , Reyes-Aldasoro Constantino Carlos , Vigilante Alessandra , Warburton Fiona , de Chaumont Fabrice , Dufour Alexandre , Dallongeville Stephane , Olivo-Marin Jean-Christophe , Knight Robert 
Published: October 2020

ABSTRACT
Accurate measurements of cell morphology and behaviour are fundamentally important for understanding how disease, molecules and drugs affect cell function in vivo. Here, by using muscle stem cell (muSC) responses to injury in zebrafish as our biological paradigm, we established a ‘ground truth’ for muSC behaviour. This revealed that segmentation and tracking algorithms from commonly used programs are error-prone, leading us to develop a fast semi-automated image analysis pipeline that allows user-defined parameters for segmentation and correction of cell tracking. Cell Tracking Profiler (CTP) is a package that runs two existing programs, HK Means and Phagosight within the Icy image analysis suite, to enable user-managed cell tracking from 3D time-lapse datasets to provide measures of cell shape and movement. We demonstrate how CTP can be used to reveal changes to cell behaviour of muSCs in response to manipulation of the cell cytoskeleton by small-molecule inhibitors. CTP and the associated tools we have developed for analysis of outputs thus provide a powerful framework for analysing complex cell behaviour in vivo from 4D datasets that are not amenable to straightforward analysis.
The single flagellum of Leishmania has a fixed polarisation of its asymmetric beat
Authors: Wang Ziyin , Beneke Tom , Gluenz Eva , Wheeler Richard John 
Published: October 2020

ABSTRACT
Eukaryotic flagella undertake different beat types as necessary for different functions; for example, the Leishmania parasite flagellum undergoes a symmetric tip-to-base beat for forward swimming and an asymmetric base-to-tip beat to rotate the cell. In multi-ciliated tissues or organisms, the asymmetric beats are coordinated, leading to movement of the cell, organism or surrounding fluid. This coordination involves a polarisation of power stroke direction. Here, we asked whether the asymmetric beat of the single Leishmania flagellum also has a fixed polarisation. We developed high frame rate dual-colour fluorescence microscopy to visualise flagellar-associated structures in live swimming cells. This showed that the asymmetric Leishmania beat is polarised, with power strokes only occurring in one direction relative to the asymmetric flagellar machinery. Polarisation of bending was retained in deletion mutants whose flagella cannot beat but have a static bend. Furthermore, deletion mutants for proteins required for asymmetric extra-axonemal and rootlet-like flagellum-associated structures also retained normal polarisation. Leishmania beat polarisation therefore likely arises from either the nine-fold rotational symmetry of the axoneme structure or is due to differences between the outer doublet decorations.
N, S Codoped Iron-carbon-based Electrocatalyst for Oxygen Reduction Reaction via Salt Recrystallization Strategy
Authors: Wu Guangping , Nie Yao 
Published: October 2020

Abstract
We prepared a kind of iron-carbon-based non-precious catalyst doped with N and S simultaneously (Fe/N/S/C) by using a salt recrystallization method. The electrochemical test results demonstrated that the Fe/N/S/C catalyst obtained by the salt recrystallization method showed a much better catalytic activity for ORR than that without using the salt recrystallization under the acidic condition. The Fe/N/S/C catalyst also exhibits an excellent ORR stability and anti-methanol activity.
UK adaptive radiotherapy practices for head and neck cancer patients
Authors: LEE Victor Shing-Cheung , SchettIno Giuseppe , Nisbet Andrew 
Published: October 2020

Objective: To provide evidence on the extent and manner in which adaptive practices have been employed in the UK and identify the main barriers for the clinical implementation of adaptive radiotherapy (ART) in head and neck (HN) cancer cases. Methods: In December 2019, a Supplementary Material 1, of 23 questions, was sent to all UK radiotherapy centres (67). This covered general information to current ART practices and perceived barriers to implementation. Results: 31 centres responded (46%). 56% responding centres employed ART for between 10 and 20 patients/annum. 96% of respondents were using CBCT either alone or with other modalities for assessing “weight loss” and “shell gap,” which were the main reasons for ART. Adaptation usually occurs at week three or four during the radiotherapy treatment. 25 responding centres used an online image-guided radiotherapy (IGRT) approach and 20 used an offline ad hoc ART approach, either with or without protocol level. Nearly 70% of respondents required 2 to 3 days to create an adaptive plan and 95% used 3–5 mm adaptive planning target volume margins. All centres performed pre-treatment QA. “Limited staff resources” and “lack of clinical relevance” were identified as the two main barriers for ART implementation. Conclusion: There is no consensus in adaptive practice for HN cancer patients across the UK. For those centres not employing ART, similar clinical implementation barriers were identified. Advances in knowledge: An insight into contemporary UK practices of ART for HN cancer patients indicating national guidance for ART implementation for HN cancer patients may be required
Students’ Feedback about Feedback; Have our PBL tutors started the shift towards a dialogic ask-tell-ask approach?
Authors: Saeed Majda , Isnani Arthur C. , Khan Samina A. , Khamis Nehal 
Published: October 2020

Objective: A paradigm shift towards a PBL bidirectional dialogic feedback can enhance learners’ performance. This study aimed to investigate undergraduate medical students’ perceptions of their PBL feedback.
Methods: We sent e-mail invitations to a web-based survey to year one and two students at College of Medicine, King Saud University. Items included the process, content, and benefits of PBL feedback.
Results: Of 209 respondents, 110 (53%) were first and 99 (47%) were second-year students. About 50% agreed that the feedback was regularly provided at scheduled timing and 72% perceived feedback environment as non-threatening. Agreement rates that the tutors asked students first to assess their performance, tell them what went well, what the areas for improvement are and develop with them an improvement plan were 59%, 61%, 61% and 52%, respectively. 61% agreed that tutors judged performance not personality. More year one students significantly agreed that the PBL feedback helped them to improve their knowledge acquisition and non-technical skills.
Conclusion: Many of our PBL tutors have started the shift to a dialogic bidirectional feedback. We recommend continuing the faculty development efforts, peer-reviewing, and seeking student’s feedback within the academic quality satisfaction surveys.
Abbreviations: PBL: Problem-based learning, ATA: Ask-Tell-Ask, CoM: College of Medicine, KSU: King Saud University.
doi: https://doi.org/10.12669/pjms.36.7.1778
How to cite this:Saeed M, Isnani AC, Khan SA, Khamis N. Students’ Feedback about Feedback; Have our PBL tutors started the shift towards a dialogic ask-tell-ask approach? Pak J Med Sci. 2020;36(7):1698-1702. doi: https://doi.org/10.12669/pjms.36.7.1778
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Validity of STONE Score in Clinical Prediction of Ureteral Stone Disease
Authors: Malik Abdul , Mohkumuddin Syed , Yousaf Shazia , Baig Mirza Ahmad Raza , Afzal Ayesha 
Published: October 2020

Objective: To determine the external validity of STONE score for predicting the probability of ureteral stone in patients presenting in emergency department with suspicion of ureteral stones.
Methods: In this prospective validation study, a total of 134 patients aged above 18 years, and first time arrived in the emergency unit for treatment of flank pain and then referred for the CT scan for suspected ureteral stone in Sandeman Provincial Hospital, Quetta, from 10-June-2018 to 15-Oct-2019 were included. STONE score calculation was done before sending the patient to the CT scan, using the same protocol as defined by Moore et al. Based on STONE score patients classified into the low-risk group (0 to 5), moderate-risk group (5 to 9) and the high-risk group (10 to13). The AUC, sensitivity, specificity and test characteristics were calculated for STONE score.
Results: The mean age was 39.2± 11.2 years, there were 86 (64.17%) men and 48 (35.83%) women. there were 26.8% patients having low-risk score, 52.23% moderate-risk and 21.97% high-risk score. On receiver operating curve (ROC) the area under curve (AUC) of the stone score was 0.75 (95% CI, 0.67 to 0.83), the lower band of AUC 0.67 and upper band 0.83. In high risk STONE score the sensitivity of STONE score was 66.7% and specificity was 75.0%.
Conclusion: Based on our study results, CT scan and ultrasonography are standard diagnostic tools for suspected ureterolithiasis but in emergency unit, use of STONE score to categorize the patient as low risk, moderate-risk and high-risk of ureteral stone can help the physician (clinician) to take decision either there is a need of further investigation or not.
doi: https://doi.org/10.12669/pjms.36.7.2625
How to cite this:Malik A, Mohkumuddin S, Yousaf S, Baig MAR, Afzal A. Validity of STONE Score in Clinical Prediction of Ureteral Stone Disease. Pak J Med Sci. 2020;36(7):1693-1697. doi: https://doi.org/10.12669/pjms.36.7.2625
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Dens Evaginatus – ‘Addition Beats Subtraction’
Authors: Ayub Khawer , Khan Sadia , Kelleher Martin 
Published: October 2020

This case describes the presentation of dens evaginatus on a maxillary central incisor in an 8-year-old Caucasian male, its subsequent monitoring and later management. Dens evaginatus is a dental anomaly most commonly noted as an accessory tubercle on the occlusal surface of premolars and the palatal aspect of incisors as a talon cusp. Complications can result in loss of pulp vitality, sometimes causing periapical periodontitis. Clinicians should be aware of the presentation and the advantages of different approaches to the management of dens evaginatus.CPD/Clinical Relevance: To raise awareness of dens evaginatus in dental professionals working in primary and secondary care.
Rhinosinusitis update
Authors: Hopkins Claire 
Published: October 2020

Rhinosinusitis is a common condition, affecting more than one in ten adults. This article will review current management strategies. While multi-factorial in aetiology, odontogenic rhinosinusitis is an important subgroup that is often misdiagnosed and recalcitrant to management. Patients with rhinosinusitis often report facial pain, but when it is severe, and mismatched in severity to other sinonasal symptoms, facial migraine should be suspected. Finally, the risks of implantation in the setting of maxillary sinus mucosal thickening and the need for ENT referral in such cases will be discussed. CPD/Clinical Relevance: Sinus issues may present to a dentist as dental pain, and dental disease may itself cause sinusitis. With increasing use of cone beam imaging, sinus pathology will be detected frequently in dental practice and this review will help to advise practitioners on current best practice.
Controversies in endodontic access cavity design: A literature review
Authors: Maqbool Manahil , Noorani Tahir Yusuf , Asif Jawaad Ahmed , Makandar Saleem D , Jamayet Nafij Bin 
Published: October 2020

The purpose of this article is to compare and contrast the different types of endodontic access cavity designs based on the current available evidence. Four types of access cavity designs, namely, traditional endodontic access cavity design (TEC), contracted/conservative endodontic access cavity design (CEC), ultra-conservative or ninja endodontic access cavity design (NEC) and truss endodontic access cavity design (TREC) have been suggested, and the latter three are currently in the limelight. Studies in vitro have been performed comparing the TECs, CECs, TRECs and NECs; except for the TECs, the other three types have not undergone clinical trials on patients. The choice of endodontic access cavity design affects fracture strength of the tooth, but remnants of pulpal tissue, due to ineffective instrumentation, can cause root canal treatment failure. CPD/Clinical Relevance: Root canal treatment with new access cavity designs has been proposed. However, there is lack of evidence to support such practices. It is important to consider the potential deleterious effects of such access cavity designs rather than emphasizing the preservation of tooth structure alone.
Limiting infusion and observation times for infliximab and vedolizumab in the COVID-19 pandemic: a UK multicentre audit of practice and safety
Authors: Avery Pearl , Younge Lisa , Clair-Jones Anya St , Campbell Rachel , Braim Deirdre , George Becky , Johnson Heather , Naughton Tracy , Rees Fiona , Maw Frances 
Published: October 2020

Background:Infusions units in the UK are under increasing pressure, and this has been increased by the SARS-COV-2 pandemic. People with inflammatory bowel disease (IBD) are considered vulnerable, requiring enhanced social distancing or shielding, as defined in the UKz government's recommendations for COVID-19. Evidence that post-infusion observation time is unnecessary for infliximab (IFX) and vedolizumab (VDZ) exists in the literature, but the summary of product characteristics for both agents states that anywhere from 0.5 hours to 2 hours of observation post-infusion is required.Methods:A call was put out using the Royal College of Nursing's Facebook page, and IBD nurses from eight trusts in the UK took part. Data were gathered on trusts' current practice, infusion times for IFX and VDZ and reported infusion reactions.Results:Two (25%) trusts reported already having reduced post-infusion observation periods for people receiving IFX infusions 1–3; this increased to three units (37.5%) for infusions 4–9 and six (75%) for infusions >10. No infusion reactions were seen after the first 20 minutes of infusion time in 3934 IFX and 1265 VDZ infusions.Conclusions:The audit results suggested that there is no safety signal reduced post-infusion observation time, supporting evidence already present in the literature, and this can support increased capacity in infusion units. The time burden for people with Crohn's disease (CD) or ulcerative colitis (UC) is reduced, which is increasingly important during the pandemic. The reduced length of time that people need to spend at hospital offers trusts an option to help shield those who need to be protected from COVID-19.
Laser ultrasonic imaging for defect detection on metal additive manufacturing components with rough surfaces
Authors: Zhang Jun , Wu Jinfeng , Zhao Xin , Yuan Shuxian , Ma Guanbing , Li Jiaqi , Dai Ting , Chen Huaidong , Yang Bing , Ding Hui 
Published: October 2020

Defects or discontinuities are inevitable during the melting and consolidation process of metal additive manufacturing. Online inspection of microdefects during the processing of layer-by-layer fusion is urgently needed for quality control. In this study, the laser ultrasonic C-scan imaging system is established to detect the surface defects of selective laser melting (SLM) samples that have a different surface roughness. An autosizing method based on the maximum correlation coefficient and lag time is proposed to accurately measure the defect length. The influences of the surface roughness on the laser ultrasound signal-to-noise ratio distribution and defect sizing accuracy are also studied. The results indicate that the proposed system can detect notches with a depth of 50 µm and holes with a diameter of 50 µm, comparable in size to raw powder particles. The average error for the length measurement can reach 1.5% if the notch is larger than 2 mm. Meanwhile, the sizing error of a 1 mm length notch is about 9%. In addition, there is no need to remove the rough surface of the as-built SLM samples during the detection process. Hence, we propose that the laser ultrasonic imaging system is a potential method for online inspection of metal additive manufacturing.
Penentuan Daerah Penyangga Kawasan Taman Hutan Raya Bukit Soeharto di Kecamatan Samboja, Kutai Kartanegara
Authors: Ariyani Desy , Syafitri Elin Diyah , Yorika Rahmi 
Published: October 2020

Taman Hutan Raya (Tahura) Bukit Soeharto merupakan kawasan konservasi yang ditetapkan berdasarkan Keputusan Menteri Kehutanan 1231 tahun 2017 memiliki luas 64.814,98 Ha, dari total luasan terdapat pemanfatan lahan pertambangan dengan luas 956 Ha, perkebunan seluas 52 Ha, permukiman atau lahan terbangun seluas 173 Ha dan petanian dengan luas 16.915 Ha. Dimana terdapat 21,29% dari total luas Taman Hutan Raya Bukit Soeharto dan daerah penyangga yang dipergunakan untuk pertambangan, pertanian lahan kering campuran, pertanian lahan kering, tanah kosong /terbuka, pemukiman, tambak/perikanan dan perkebunan. Hal ini dikarenakan masyarakat tidak mengetahui batasan wilayah untuk memanfaatkan sumberdaya hutan sehingga terjadi pemanfataan lahan yang tidak seharusnya. Selain itu, masyarakat juga tidak mengetahui bahwa kawasan konservasi tidak boleh dimanfaatkan. Penelitian ini bertujuan untuk menentukan wilayah yang berfungsi sebagai daerah penyangga kawasan Taman Hutan Raya (Tahura) Bukit Soeharto. Penelitian menggunakan metode overlay peta dengan alat analisis Arcgis 10.7 dengan parameter penentuan fungsi kawasan adalah kemiringan lahan, jenis tanah dan curah hujan. Berdasarkan hasil analisis yang telah dilakukan diperoleh hasil bahwa terdapat wilayah dengan luas sebesar 2.2 Ha yang memiliki fungsi sebagai daerah penyangga. Wilayah tersebut termasuk dalam wilayah administrasi Kelurahan Sungai Merdeka, Wonotirto, dan Karya Jaya
Challenges of Curbing Criminality in Nigeria’s Maritime Domain and its Attendance Implications on Youth Empowerment
Authors: Etuk Etiese 
Published: October 2020

Increasing cases of piracy, sea robbery, illegal bunkering and unauthorized mid-stream discharge, among several other criminalities, constitute a major source of concern to maritime administrations in the Gulf of Guinea, including that of Nigeria.
Youth restiveness especially on the waterways of the Nigerian waters is of great concern to the government of Nigeria and the international communities. Youths grudges hinge on the gross negligence by the multinational oil exploration and production companies operating in the domains on areas of youth employment and empowerment, environmental devastation, education, negligence on environmental impacts restorations etc.
While Nigerian current maritime security regulatory framework is not robust enough, enhancement must be made over time in order to continuously improve and deliver a secured maritime transportation system in Nigeria.
The youths on the other hand inadvertently believe that by robbing in the water ways, kidnapping of individuals in the water ways for money, sabotaging oil pipelines, hijacking ships and vessels in the water ways and emptying their contents and then re-selling same to other buyers is a quick source of financial empowerment of the youths.
SYSTEMATIC MAPPING OF PERFORMANCE ASSESSMENT RESEARCH: BIBLIOMETRIC STUDY WITH VOSVIEWER
Authors: Purwayadi Teguh 
Published: October 2020

This article aims to find a map of the development of research on performance assessment. The study was conducted by searching through the Scopus database with the keyword performance assessment. The data from the search results are then analyzed descriptively based on the year of publication, the country that published the performance assessment research, and the focus of the research. To obtain a map of research development, the data from the Scopus database is exported into a Comma Separated Values ​​(CSV) file format, then processed and analyzed using the VOSViewer application program to find out the bibliometric map of the development of performance assessment research.
The results of the systematic mapping conducted show that the trend of performance assessment research publications indexed in Scopus from 2011 to 2020 has fluctuated. The trend based on the country that published the most articles was the United Kingdom with 77 articles. The research topic that is mostly done is the study of performance measurement with 32 articles. Then, through VOSViewer visualization, it shows that the map of the development of performance assessment research is divided into 5 clusters, namely; Cluster 1 consists of 6 research topics, namely assessment, efficiency, evaluation, performance, public service, and sustainability; Cluster 2 consists of 5 research topics, namely balanced scorecard, benchmarking, data envelopment analysis, performance assessment, and performance indicators; Cluster 3 consists of 5 research topics, namely accountability, Canada, governance, performance measurement, and public management; Cluster 4 consists of 4 research topics, namely local government, performance management, public administration, and public sector reform; Cluster 5 consists of 3 research topics, namely job satisfaction, performance evaluation, and the public sector.
Indonesian Islamic Moderation for National Defence
Authors: Saleh Ahmad Junaidi 
Published: October 2020

The phenomenon movement of Moslems on early 21th century is shown hight intensitily. This is indicated by Islamic political movements which are dominated by non-mainstream Islamic movements which have influence many maps of Islamic movements, include in Indonesia. On moderate side Islamic groups as mainstream still appear with their old patterns of displaying open harmonious variants of Islam, tolerant and modest locality of Islamic traditional and building Islamic civilization and humanity in Indonesia. As the majority of the world's most Moslem population in a pluralistic and pluralist community, existence of moderate Islam is very important in the national defense system. This article uses a qualitative approach with data sources from references and literature relating to Islamic moderation. The validity and reliability of the data is done by triangulation reference. The method on this study is a qualitative method. Data collection techniques are literature and documentation. From this study, the results are obtained that the presence of moderate Islam will be able toward off the dynamics of threats, which move from a national defense system.
Keywords: Islamic moderation, State Defence
Literature Review of Treasury Cash Flow Forecast
Authors: Hua Shi 
Published: October 2020

In this paper, the related literatures of treasury cash flow forecasting in the early stage are reviewed. By reviewing the related literatures, it is found that the treasury cash flow forecasting in China has made great progress, and various forecasting methods have been used in practical work, but there is still room for optimization in treasury cash flow forecasting. Suggestions for optimization are put forward.
Un acercamiento a la lírica de Helena Ospina en Sonata de otoño: Canción consumada
Authors: Palacios Conny 
Published: October 2020

An approach to Helena Ospina`` s lyrics is a general and ambitious title, because I want to analyze the mystical poetry of the author. It is a task that I have assigned myself in stages. On this occasion I will refer specifically to Autumn Sonata. Consummated song (1995). In this paper I will study the mystical process involved and make reference to the symbolic use of the number three, as well as other symbols which I consider essential in her lyrics and that are present in this work.