bluuebunny/crossref_metadata_2025_split huggingface dataset:
ASME Section VI: Recommended Rules for the Care and Operation of Heating Boilers
Authors: Smith Clayton T. 
Published: December 2019

Abstract
This chapter provides criteria and commentary for ASME Section VI, which presents guidelines for the safe and efficient operation of steam-heating boilers, hot-water-supply boilers, and hot-water-heating boilers after installation. These rules are nonmandatory unless they are adopted into the laws of a governmental jurisdiction. The chapter is divided into nine parts, along with the necessary figures and tables for each part. Part 1 covers the scope of the chapter, provides some background on the use of illustrations and manufacturer’s information, and includes a glossary of terms applicable to boilers, fuels, fuel-burning equipment, combustion, and water treatment. Part 2 deals with the classification of boilers based on their design, construction, and application. Different types of boilers, such as steel, cast iron, modular, and vacuum boilers, are described and illustrated. The requirements of accessories such as safety relief valves and pressure gages, and their installation are addressed in Part 3. Part 4 deals with the characteristics of common fuels used for combustion in boilers such as gas, oil, coal, and wood products. Part 5 provides information on the controls for managing the functions of the fuel-burning equipment, namely operating, limit, safety, and programming controls. Part 6 covers all the requirements of boiler-room facilities for safe operation and maintenance. Recommendations for the operation, maintenance, and repair of steam boilers are included in Part 7 in addition to the procedures for inspection of steam boilers. Part 8 deals with the operation, maintenance, and repair guidelines for hot-water boilers and tests and inspections of hot-water-supply and hot-water-heating boilers. Water treatment considerations, boiler water problems, the chemicals used for water treatment and their functions, treatment alternatives, and various procedures are discussed in Part 9.
Association between caring for grandchildren and feelings of loneliness, social isolation and social network size: a cross-sectional study of community dwelling adults in Germany
Authors: Quirke Eleanor , König Hans-Helmut , Hajek André 
Published: December 2019

ObjectiveThe aim of this study was to examine whether there is an association between grandparental care and loneliness, social isolation and/or the size of an individual’s social network among community-based adults aged ≥40 years.MethodsCross-sectional data were drawn from a population-based sample of individuals aged ≥40 years living in the community in Germany. Loneliness was measured using a short version of the De Jong Gierveld Loneliness Scale. Social isolation was measured using a scale developed by Bude and Lantermann. The number of important people with whom respondents have regular contact (ie, social network size) was also used as an outcome variable. All respondents were asked whether they privately provide grandparent care (no/yes).ResultsLinear regressions showed reduced loneliness (β=−0.06, p<0.01) and social isolation scores (β=−0.04, p<0.05) among those undertaking care of a grandchild. Regression analysis also showed an increased number of important people with whom individuals had regular contact among those who undertook care of a grandchild (β=1.02, p<0.001).ConclusionFindings indicate a positive association between undertaking the care of a grandchild and the size of an individual’s social network, and a negative association between grandchild care and self-rated scores of loneliness and social isolation. These findings build on existing research into the social and health implications of grandchild care among grandparents. Longitudinal studies are required to strengthen the understanding of this association.
Key components of shared decision making models: a systematic review
Authors: Bomhof-Roordink Hanna , Gärtner Fania R , Stiggelbout Anne M , Pieterse Arwen H 
Published: December 2019

ObjectivesTo (1) provide an up-to-date overview of shared decision making (SDM)-models, (2) give insight in the prominence of components present in SDM-models, (3) describe who is identified as responsible within the components (patient, healthcare professional, both, none), (4) show the occurrence of SDM-components over time, and (5) present an SDM-map to identify SDM-components seen as key, per healthcare setting.DesignSystematic review.Eligibility criteriaPeer-reviewed articles in English presenting a new or adapted model of SDM.Information sourcesAcademic Search Premier, Cochrane, Embase, Emcare, PsycINFO, PubMed, and Web of Science were systematically searched for articles published up to and including September 2, 2019.ResultsForty articles were included, each describing a unique SDM-model. Twelve models were generic, the others were specific to a healthcare setting. Fourteen were based on empirical data, 26 primarily on analytical thinking. Fifty-three different elements were identified and clustered into 24 components. Overall, Describe treatment optionswas the most prominent component across models. Components present in >50% of models were:Make the decision (75%),Patient preferences (65%),Tailor information (65%),Deliberate (58%), Create choice awareness (55%), andLearn about the patient(53%). In the majority of the models (27/40), both healthcare professional and patient were identified as actors. Over time,Describe treatment optionsandMake the decisionare the two components which are present in most models in any time period.Create choice awarenessstood out for being present in a markedly larger proportion of models over time.ConclusionsThis review provides an up-to-date overview of SDM-models, showing that SDM-models quite consistently share some components but that a unified view on what SDM is, is still lacking. Clarity about what SDM constitutes is essential though for implementation, assessment, and research purposes. A map is offered to identify SDM-components seen as key.Trial registrationPROSPERO registration CRD42015019740
Patient-generated health data and electronic health record integration: protocol for a scoping review
Authors: Tiase Victoria L , Hull William , McFarland Mary M , Sward Katherine A , Del Fiol Guilherme , Staes Catherine , Weir Charlene , Cummins Mollie R 
Published: December 2019

IntroductionThe objective of this study is to determine the extent and describe the nature of patient-generated health data (PGHD) integration into electronic health records (EHRs) using systematic scoping methods to review the available literature. PGHD have the potential to enhance decision making by providing the valuable information that may not be ordinarily captured during a routine care visit. These data which are captured from mobile devices, such as smartphones, activity trackers and other sensors, should be integrated into clinical workflows to allow for optimal use by clinicians.Methods and analysisThis study aims to conduct a rigorous scoping review to explore evidence related to the integration of PGHD into EHRs. Using the framework developed by Arksey and O’Malley, we will create a systematic search strategy, chart data from the relevant articles, and use a qualitative, thematic approach to analyse the data. This review will enable the identification of types of integration and describe challenges and barriers to integrating PGHD.Ethics and disseminationDatabase searches will be initiated in June 2019. The review is expected to be completed by October 2019. As the content of the full-text articles emerges, the authors will summarise the characteristics related to the integration of PGHD. The findings of this scoping review will identify research gaps and present implications for future research.
Attitudes of physicians towards target groups and content of the discharge summary: a cross-sectional analysis in Styria, Austria
Authors: Hoffmann Magdalena , Schwarz Christine Maria , Pregartner Gudrun , Weinrauch Maximilian , Jantscher Lydia , Kamolz Lars , Brunner Gernot , Sendlhofer Gerald 
Published: December 2019

ObjectivesThe discharge summary (DS) represents one of the most important instruments to ensure a safe patient discharge from the hospital. They sometimes have poor quality in content and often include medical jargon, which the patient and their relatives cannot easily understand. Therefore, many risks for patient safety exist. This study investigated the questions for whom the DS is and which contents are necessary to ensure a safe treatment.DesignCross-sectional analysis.SettingStyria, Austria.Participants3948 internal and external physicians were consulted.InterventionsAn online survey consisting of 24 questions was conducted. The survey was distributed to physicians working in the province of Styria, Austria, in 2018 over a period of 6 months.Main outcomes and measuresAttitudes of internal and external physicians in terms of target group, content and health literacy.ResultsIn total, 1060 physicians participated in the survey. The DS is considered as a communication tool among physicians (97.9%) and the patients are also indicated as addressees (73.5%). Furthermore, there is a high level of agreement that understandable information in the DS leads to fewer questions of the patients (67.9%).ConclusionIn conclusion, the DS is not only seen as a document for the further treating physician but is also relevant for the patient. Incorporating the patient into their treatment at all levels may possibly strengthen the individual health literacy of the patient and their caring relatives.
HIIT is not superior to MICT in altering blood lipids: a systematic review and meta-analysis
Authors: Wood Gina , Murrell Anna , van der Touw Tom , Smart Neil 
Published: December 2019

ObjectiveTo compare the effects of moderate intensity continuous training (MICT) and high intensity interval training (HIIT) on adult lipid profiles; to identify training or participant characteristics that may determine exercise-induced change in total cholesterol (TC), triglycerides (TRG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C).DesignSystematic review and meta-analysis.Data sourcesEnglish language searches of several databases were conducted from inception until September 2019.Eligibility criteria for excluding studiesInclusion: (1) published randomised controlled human trials with group population n≥5; (2) intervention duration ≥4 weeks; (3) comparing HIIT with MICT; and (4) reporting pre–post intervention lipid measurements. Exclusion: subjects with chronic disease, <18 years, pregnant/lactating, in elite athletic training; and studies with a dietary or pharmaceutical intervention component.ResultsTwenty-nine data sets (mmol/L) of 823 participants were pooled and analysed. Neither HIIT nor MICT was better in decreasing TC (0.10 (−0.06 to 0.19), p=0.12, I2=0%), TRG (−0.05 (−0.11 to 0.01), p=0.10, I2=0%), LDL-C (0.05 (−0.06 to 0.17), p=0.37, I2=0%), or TC/HDL-C (−0.03 (−0.36 to 0.29), p=0.85, I2=0%). HIIT significantly raised HDL-C (0.07 (0.04 to 0.11), p<0.0001, I2=0%) compared with MICT.ConclusionNeither HIIT nor MICT is superior for altering TC, TRG, or LDL-C, or TC-HDL-C ratio. Compared with MICT, HIIT appeared to significantly improve HDL-C. Clinicians may prescribe either protocol to encourage participation in exercise and reduce cardiovascular risk. To raise HDL-C, HIIT may result in a larger effect size compared with MICT.PROSPERO registration numberCRD42019136722.
Histopathologist features predictive of diagnostic concordance at expert level among a large international sample of pathologists diagnosing Barrett’s dysplasia using digital pathology
Authors: van der Wel Myrtle J , Coleman Helen G , Bergman Jacques J G H M , Jansen Marnix , Meijer Sybren L 
Published: December 2019

ObjectiveGuidelines mandate expert pathology review of Barrett’s oesophagus (BO) biopsies that reveal dysplasia, but there are no evidence-based standards to corroborate expert reviewer status. We investigated BO concordance rates and pathologist features predictive of diagnostic discordance.DesignPathologists (n=51) from over 20 countries assessed 55 digitised BO biopsies from across the diagnostic spectrum, before and after viewing matched p53 labelling. Extensive demographic and clinical experience data were obtained via online questionnaire. Reference diagnoses were obtained from a review panel (n=4) of experienced Barrett’s pathologists.ResultsWe recorded over 6000 case diagnoses with matched demographic data. Of 2805 H&E diagnoses, we found excellent concordance (>70%) for non-dysplastic BO and high-grade dysplasia, and intermediate concordance for low-grade dysplasia (42%) and indefinite for dysplasia (23%). Major diagnostic errors were found in 248 diagnoses (8.8%), which reduced to 232 (8.3%) after viewing p53 labelled slides. Demographic variables correlating with diagnostic proficiency were analysed in multivariate analysis, which revealed that at least 5 years of professional experience was protective against major diagnostic error for H&E slide review (OR 0.48, 95% CI 0.31 to 0.74). Working in a non-teaching hospital was associated with increased odds of major diagnostic error (OR 1.76, 95% CI 1.15 to 2.69); however, this was neutralised when pathologists viewed p53 labelled slides. Notably, neither case volume nor self-identifying as an expert predicted diagnostic proficiency. Extrapolating our data to real-world case prevalence suggests that 92.3% of major diagnostic errors are due to overinterpreting non-dysplastic BO.ConclusionOur data provide evidence-based criteria for diagnostic proficiency in Barrett’s histopathology.
Performance analysis of different turbulence models in impinging jet cooling
Authors: Pawar Shashikant , Patel Devendra Kumar 
Published: December 2019

The characteristics of heat transfer from a hot wall surface for the oblique impingement of a free turbulent slot jet have been investigated numerically. Different turbulent models — the [Formula: see text]-[Formula: see text], [Formula: see text]-[Formula: see text], SST [Formula: see text]-[Formula: see text], cubic [Formula: see text]-[Formula: see text] and quadratic [Formula: see text]-[Formula: see text] models — are used for the prediction of heat transfer and their results were compared with experimental results reported in the literature. The comparison shows that the [Formula: see text]-[Formula: see text], quadratic [Formula: see text]-[Formula: see text] and SST [Formula: see text]-[Formula: see text] models give more unsatisfactory results for the investigated configuration, while the cubic [Formula: see text]-[Formula: see text] model is capable of predicting the local Nusselt number in wall-jet region only. The [Formula: see text]-[Formula: see text] model exhibits the best agreement with the experimental results in both stagnation and wall-jet regions. Further, the [Formula: see text]-[Formula: see text] model is applied to analyze the obliquely impinging jet heat transfer problem. The parametric effects of the jet inclination ([Formula: see text], [Formula: see text] and [Formula: see text]), jet-to-surface distance ([Formula: see text], 6 and 8), Reynolds number ([Formula: see text], 15[Formula: see text]000 and 20[Formula: see text]000), and turbulent intensity ([Formula: see text], [Formula: see text] and [Formula: see text]) have been presented. The heat transfer on the upward direction is seen to decrease, while that on the downward direction it rises for the increasing angle. It is to be noted that as the value of [Formula: see text] decreases, the point of maximum Nusselt number ([Formula: see text]) displaces toward the upward direction from the geometric center point as well as its value reduces. The shifting of the [Formula: see text] is found to be independent of Re and [Formula: see text] within the range considered for the study.
Rapid crossed responses in an intrinsic hand muscle during perturbed bimanual movements
Authors: Khong Katie Y. W. , Galán Ferran , Soteropoulos Demetris S. 
Published: December 2019

Mechanical perturbations in one upper limb often elicit corrective responses in both the perturbed as well as its contralateral and unperturbed counterpart. These crossed corrective responses have been shown to be sensitive to the bimanual requirements of the perturbation, but crossed responses (CRs) in hand muscles are far less well studied. Here, we investigate corrective CRs in an intrinsic hand muscle, the first dorsal interosseous (1DI), to clockwise and anticlockwise mechanical perturbations to the contralateral index finger while participants performed a bimanual finger abduction task. We found that the CRs in the unperturbed 1DI were sensitive to the direction of the perturbation of the contralateral index finger. However, the size of the CRs was not sensitive to the amplitude of the contralateral perturbation nor its context within the bimanual task. The onset latency of the CRs was too fast to be purely transcortical (<70 ms) in 12/12 participants. This confirms that during isolated bimanual finger movements, sensory feedback from one hand can influence the other, but the pathways mediating the earliest components of this interaction are likely to involve subcortical systems such as the brainstem or spinal cord, which may afford less flexibility to the task demands. NEW & NOTEWORTHY An intrinsic hand muscle shows a crossed response to a perturbation of the contralateral index finger. The crossed response is dependent on the direction of the contralateral perturbation but not on the amplitude or the bimanual requirements of the movement, suggesting a far less flexible control policy than those governing crossed responses in more proximal muscles. The crossed response is too fast to be purely mediated by transcortical pathways, suggesting subcortical contributions.
The small fiber neuropathy NaV1.7 I228M mutation: impaired neurite integrity via bioenergetic and mitotoxic mechanisms, and protection by dexpramipexole
Authors: Lee Seong-il , Hoeijmakers Janneke G. J. , Faber Catharina G. , Merkies Ingemar S. J. , Lauria Giuseppe , Waxman Stephen G. 
Published: December 2019

Gain-of-function variants in voltage-gated sodium channel NaV1.7 that increase firing frequency and spontaneous firing of dorsal root ganglion (DRG) neurons have recently been identified in 5–10% of patients with idiopathic small fiber neuropathy (I-SFN). Our previous in vitro observations suggest that enhanced sodium channel activity can contribute to a decrease in length of peripheral sensory axons. We have hypothesized that sustained sodium influx due to the expression of SFN-associated sodium channel variants may trigger an energetic deficit in neurons that contributes to degeneration and loss of nerve fibers in SFN. Using an ATP FRET biosensor, we now demonstrate reduced steady-state levels of ATP and markedly faster ATP decay in response to membrane depolarization in cultured DRG neurons expressing an SFN-associated variant NaV1.7, I228M, compared with wild-type neurons. We also observed that I228M neurons show a significant reduction in mitochondrial density and size, indicating dysfunctional mitochondria and a reduced bioenergetic capacity. Finally, we report that exposure to dexpramipexole, a drug that improves mitochondrial energy metabolism, increases the neurite length of I228M-expressing neurons. Our data suggest that expression of gain-of-function variants of NaV1.7 can damage mitochondria and compromise cellular capacity for ATP production. The resulting bioenergetic crisis can consequently contribute to loss of axons in SFN. We suggest that, in addition to interventions that reduce ionic disturbance caused by mutant NaV1.7 channels, an alternative therapeutic strategy might target the bioenergetic burden and mitochondrial damage that occur in SFN associated with NaV1.7 gain-of-function mutations. NEW & NOTEWORTHY Sodium channel NaV1.7 mutations that increase dorsal root ganglion (DRG) neuron excitability have been identified in small fiber neuropathy (SFN). We demonstrate reduced steady-state ATP levels, faster depolarization-evoked ATP decay, and reduced mitochondrial density and size in cultured DRG neurons expressing SFN-associated variant NaV1.7 I228M. Dexpramipexole, which improves mitochondrial energy metabolism, has a protective effect. Because gain-of-function NaV1.7 variants can compromise bioenergetics, therapeutic strategies that target bioenergetic burden and mitochondrial damage merit study in SFN.
The Neural Consequences of Attentional Prioritization of Internal Representations in Visual Working Memory
Authors: Sahan Muhammet I. , Sheldon Andrew D. , Postle Bradley R. 
Published: December 2019

Abstract
Although humans can hold multiple items in mind simultaneously, the contents of working memory (WM) can be selectively prioritized to guide future behavior. We explored whether the “same-object” benefits in visual processing may also be observed in visual WM. fMRI data were collected while participants performed a multistep serial retrocuing task in which they first viewed two 2-D objects (coherently moving colored dots). During retention, an initial relevance cue then indicated whether only the first or only the second object (“object-relevant”), or only the color of both objects or only their direction of motion would be relevant for the remainder of the trial (“feature-relevant”). On “object-relevant” trials, the ensuing priority cues selected either one of the features (“color” or “direction”) bound to the relevance-cued object, whereas on “feature-relevant” trials, the priority cues selected one of the two relevance-cued features. Using multivariate inverted encoding models, we found a same-object benefit on object-relevant trials in occipitotemporal regions: On feature-relevant trials, the first priority cue triggered a strengthening of the neural representation of the cued feature and a concomitant weakening to baseline of the uncued feature, whereas on object-relevant trials, the cued item remained active but did not increase in strength and the uncued item weakened but remained significantly elevated throughout the delay period. Although the stimulus-specific representation in frontoparietal regions was weak and uneven, these regions closely tracked the higher order information of which stimulus category was relevant for behavior throughout the trial, suggesting an important role in controlling the prioritization of information in visual WM.
Evolution of Stray Dog’s Control in Italy
Authors: Levi Diana 
Published: December 2019

Abstract
During the last 30 years the law regarding stray dogs in Italy evolved from employing euthanasia for these dogs after three days, to long term kenneling of all dogs not seriously or incurably ill or proven aggressive. This was a highly ethical law whose application was extremely difficult because of the lack of financial resources and adequate kenneling facilities. It is fair, necessary and urgent to adopt ethical choices in managing problems connected with stray dogs but decisions must be taken in consideration with thorough evaluation of the situation. Is long term kenneling a correct way to safeguard dogs’ welfare? Are there tools available to evaluate the welfare of these dogs? The available data about the number of stray dogs, both in kennels and roaming, are up to date? Are there financial resources available? Do the structures necessary to accommodate these animals exist and are they adequate? Countries that still have a kill policy should consider these aspects before legislating on this issue.