bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Evaluation of the Content of Pediatric Discharge Summaries
Authors: Lakhaney Divya , Banker Sumeet L. 
Published: November 2020

OBJECTIVES:The need for high-quality discharge summaries is critical to ensure safe transitions of care. Deficits may lead to lapses in communication and poor outcomes. In this study, we sought to characterize the completeness, accuracy, and quality of pediatric discharge summaries.METHODS:A retrospective chart review of 200 discharge summaries of patients discharged from the general pediatrics service from July 2016 to October 2017 was conducted. These summaries were audited for 7 elements: admission date, discharge date, discharge diagnosis, medications, immunizations, pending laboratory tests, and follow-up appointments. Accuracy was verified through chart review. Quality of hospital course and patient instructions was evaluated by using a modified validated discharge summary evaluation tool. Additional data collected included medical complexity of the patient and the number of authors. Analysis of variance, χ2 tests, and Pearson correlations were used to analyze data.RESULTS:Discharge diagnosis, medications, and follow-up appointments had the lowest rates of completion and accuracy. The quality of the hospital course and patient instructions was variable, with no statistical significance seen in quality scores on the basis of the number of authors or medical complexity. There were more inaccuracies in discharge medications for patients with baseline chronic conditions than those without chronic conditions (63% vs 35%; P &lt; .001).CONCLUSIONS:Content and quality of discharge summary documentation are inconsistent and have implications for patient outcomes after discharge. This study highlights areas of opportunity to improve pediatric discharge summaries. Future work should be focused on educational and systems-based interventions to improve documentation.
Associations Between Quality Measures and Outcomes for Children Hospitalized With Bronchiolitis
Authors: Bryan Mersine A. , Tyler Amy , Zhou Chuan , Williams Derek J. , Johnson David P. , Kenyon Chén C. , Haq Heather , Simon Tamara D. , Mangione-Smith Rita 
Published: November 2020

OBJECTIVES:
To use adherence to the Pediatric Respiratory Illness Measurement System (PRIMES) indicators to evaluate the strength of associations for individual indicators with length of stay (LOS) and cost for bronchiolitis.

METHODS:
We prospectively enrolled children with bronchiolitis at 5 children’s hospitals between July 1, 2014, and June 30, 2016. We examined associations between adherence to each individual PRIMES indicator for bronchiolitis and LOS and cost. Sixteen indicators were included, 9 “overuse” indicators for care that should not occur and 7 “underuse” indicators for care that should occur. We performed mixed effects linear regression to examine the association between adherence to each individual indicator and LOS (hours) and cost (dollars). All models controlled for patient demographics, patient complexity, and hospital.

RESULTS:
We enrolled 699 participants. The mean age was 8 months; 56% were male, 38% were white, and 63% had public insurance. Three indicators were significantly associated with shorter LOS and lower cost. All 3 indicators were overuse indicators and related to laboratory testing: no blood cultures (adjusted mean difference in LOS: −24.3 hours; adjusted mean cost difference: −$731, P &lt; .001), no complete blood cell counts (LOS: −17.8 hours; cost: −$399, P &lt; .05), and no respiratory syncytial virus testing (LOS: −16.6 hours; cost: −$272, P &lt; .05). Two underuse indicators were associated with higher cost: documentation of oral intake at discharge ($671, P &lt; .01) and documentation of hospital follow-up ($538, P &lt; .05).

CONCLUSIONS:
A subset of PRIMES quality indicators for bronchiolitis are strongly associated with improved outcomes and can serve as important measures for future quality improvement efforts.
Early Pragmatics in Deaf and Hard of Hearing Infants
Authors: Kelly Ciara , Morgan Gary , Bannard Colin , Matthews Danielle 
Published: November 2020

BACKGROUND AND OBJECTIVES:
A set of important pragmatic skills emerge during infancy and pave the way for later language learning. It is thought these early social communication skills develop through infant–caregiver interaction. In a microanalysis, we tested whether deaf and hard of hearing (DHH) infants (typically at high risk of reduced access to rich communicative interaction in infancy) are less likely to engage in gestural and vocal pragmatic behaviors.

METHODS:
We coded the naturalistic communication of 8 DHH infants who had no additional needs, who were not preterm or low birth weight, whose parents were hearing, monolingual English speakers, and who had spoken English as their primary target language. The frequency of use of 5 types of infant communication known to positively predict later language development (show gestures, give gestures, index-finger pointing, communicative vocalizations, and early word use) was compared with that of 8 typically hearing infants matched for age, sex, and socioeconomic status.

RESULTS:
Hearing loss had a significant negative effect on the frequency with which infants engaged in all types of early communication that predict later language development.

CONCLUSIONS:
DHH infants are at high risk of delay in the gestural and vocal communicative skills that lay the foundations for later language. Delay in the gestural domain suggests this is not simply a consequence of difficulties in imitating auditory stimuli. There is significant potential to lift DHH infants onto a positive developmental trajectory by supporting caregivers to nurture interaction from the first year.
Pragmatics and Peer Relationships Among Deaf, Hard of Hearing, and Hearing Adolescents
Authors: Zaidman-Zait Anat , Most Tova 
Published: November 2020

OBJECTIVES:
The goals of the current study were to (1) examine differences in pragmatic abilities and peer relationship behaviors among deaf and hard of hearing (DHH) adolescents who use spoken language, in comparison with their hearing peers; and (2) explore the contribution of pragmatic skills and speech (ie, articulation and intelligibility [AI]) to social aspects of school functioning among DHH and typically hearing adolescents.

METHODS:
Thirty-three DHH adolescents and 34 adolescents with typical hearing participated. All DHH adolescents attended mainstream school settings and used spoken language. Teacher reports were obtained on prosocial behaviors, peer problems, pragmatic abilities, and speech AI of the adolescents. Adolescents self-reported on the supportiveness of their peer relationships and their school emotional engagement.

RESULTS:
Multiple hierarchical regression analyses revealed that DHH adolescents had greater difficulties with peers than their hearing counterparts. Increased pragmatic difficulties were related to more peer problems and decreased prosocial behaviors, regardless of adolescents’ hearing status. A significant positive correlation was found between pragmatic competence and adolescents’ perceptions of peers’ support. Finally, better speech AI were associated with higher levels of school emotional engagement.

CONCLUSIONS:
The results emphasize the significant role of pragmatics for both DHH and typically hearing adolescents. Medical care providers and allied health professionals should be aware of possible difficulties that DHH adolescents may have in complex and nuanced pragmatic skills. Some adolescents may require a referral to specialized services to support the development of their pragmatic understanding and their skills.
Kindergarten Readiness, Later Health, and Social Costs
Authors: Fitzpatrick Caroline , Boers Elroy , Pagani Linda S. 
Published: November 2020

OBJECTIVES:To estimate associations between kindergarten readiness and academic, psychological, and health risks by end of high school.METHODS:This study is based on 966 Canadian children. At age 5, trained examiners assessed child number knowledge and receptive vocabulary. Teachers reported kindergarten classroom engagement. At age 17, participants reported academic grades, school connectedness, anxiety sensitivity, substance abuse, physical activity involvement, and height and weight. High school dropout risk was also estimated for each participant on the basis of grades, school engagement, and grade retention.RESULTS:Kindergarten math skills contributed to better end-of high school grades (β = .17, P &lt; .01) and lower dropout risk (β = −.20, P &lt; .001), whereas receptive vocabulary predicted lower anxiety sensitivity (β = −.11, P &lt; .01). Kindergarten classroom engagement predicted higher end of high school grades (β = .17, P &lt; .001), lower dropout risk (β = −.20, P &lt; .01), better school connectedness (β = .15, P &lt; .01), lower risk of substance abuse (β = −.21, P &lt; .001), and more physical activity involvement (β = .09, P &lt; .05). Kindergarten classroom engagement was also associated with a 65% reduction (odds ratio = 0.35) in the odds of being overweight at age of 17. Analyses were adjusted for key child (sex, weight per gestational age, nonverbal IQ, and internalizing and externalizing behaviors) and family (parental involvement, maternal depression and immigrant status, family configuration, and socioeconomic status) characteristics.CONCLUSIONS:Early childhood readiness forecasts a protective edge by emerging adulthood. With these findings, we build links between education and health indicators, suggesting that children who start school prepared gain a lifestyle advantage. Promoting kindergarten readiness could reduce the health burden generated by high school dropout.
Using Arachis pintoi leaf extracts in biosynthesis of silver nanoparticles for improving the vase life of cut carnation (Dianthus caryophyllus L.)
Authors: Lap Xuan Tran , Ba Le Le , Anh Tu Le Thi 
Published: November 2020

A biological method for synthesizing silver nanoparticles (SNPs) using the leaf extracts of Arachis pintoi Krapov. & W.C. Greg. was developed. The optimum conditions of input materials were found with leaf autoclaving in 15 min, 20 g fresh leave, and 4 mM of silver nitrate (AgNO3). To study the role of time, temperature, and solution pH of the reaction, varying time reaction (5, 30, 60, 90, 120, 150, and 180 min), temperature reaction (10, 20, 30, 40, and 50oC) and pH of the solution (1, 3, 5, 7, 9, and 11) were investigated. The optimal biosynthesis conditions were achieved in 180 min of reaction time at 50oC and pH 11. The obtained nanoparticles have spherical and oblong in shape with average size of 26.4 nm. The SNPs in 4 concentrationss (5, 15, 25, and 35 ppm) combined with and without 2% sucrose extended vase life, enlarged flower diameter, and maintained increase the relative fresh weight with vase solution uptake rate. SNPs inhibited significantly the bacterial growth in the stem end and vase solution, reduced the blockage in stems and therefore promoted the postharvest quality of carnation cut flowers. Out of the treatments, administration of 5 ppm SNPs with 2% sucrose of vase solution gave the best results for all parameters. The biosynthesis SNPs could be applied as a promising preservative solution for carnation cut flowers.
Screening of antihyperglycaemic activity of medicinal plant extracts instreptozocin-induced type 2 diabetic mice
Authors: Xuan Thu Nguyen Thi , Duc Long Dang 
Published: November 2020

Traditional plant used for treatment of diabetes has shown a surging interest in the last few decades. The purpose of this study is to evaluate the effect of 70% (v/v) ethanolic extracts of several untested herbal sources, such as papaya leaves, papaya seeds, fig fruits, fruits of Xanthium strumarium, and leaves of Gomphrena celosioides on blood glucose levels of streptozocin (STZ)-induced type 2 diabetic mice. The results proved that diabetic mice treated with the extracts of papaya seeds, papaya leaves and fig fruits showed significant reduction of the blood glucose levels at a dose of 500 mg/kg body weight when compared to control. Antihyperglycemic activity of the papaya leaves (52.38%) and papaya seeds extracts (53.16%) were significantly higher than the extract of fig fruits (27.90%). Furthermore, the α-amylase inhibition assay showed that the extracts of papaya seeds (58,63 ± 0,06 μg/ml), papaya leaves (34,28 ± 0,06 μg/mL) and fig fruits (79,24 ± 0,83 μg/mL) exhibited 50% α-amylase inhibition activity at the mentioned concentrations. The α-glucosidase IC50 of the extracts of the papaya seeds, papaya leaves and fig fruits were found to be 24.36 ± 0,29, 27,60 ± 0,43 and 106,44 ± 1,54 respectively. The results of the study indicate the potential of these extracts to manage hyperglycemia. The histopathological study of the papaya seeds extract has shown to ameliorate the streptozocin-induced histological damage of islets of Langerhans in the pancreas.
Genetic diversity of Panax vietnamensis var. langbianensis populations in Lam Vien plateau - Vietnam detected by inter simple sequence repeat (ISSR) markers
Authors: Ngoc Trieu Le , Van Duy Nong , Van Tien Tran 
Published: November 2020

Panax vietnamensis var. langbianensis is a new variety from Lam Vien plateau of Vietnam. In this study, inter simple sequence repeat (ISSR) markers were employed to investigate the genetic diversity and variability of 115 individuals belonging to two naturally distributed populations of this variety, which classified by habitat. Genetic diversity at the taxon level was high (HeT = 0.284 and PPBT = 97.2 %). The result showed lightly higher genetic diversity in population in Lac Duong region (HeLD= 0.228 and PPBLD = 81.5 %) as compared to those located in Dam Rong region (HeDR= 0.213 and PPBDR = 79.4 %). The interpopulation gene differentiation was high (GST Total = 0.221) with the genetic distance among populations was DLD-DR = 0.191. Gene flow within populations was Nm = 0.8793. In Lac Duong population, the genetic diversity of older group (HeLD O = 0.233; PPBLD O = 77.1%) was higher than of younger group (HeLD Y = 0.214; PPBLD Y = 72.4 %) and the intergroup gene differentiation was GSTDL = 0.0205 with the genetic distance between these two group was DLD O-Y = 0.0061 showed the risk of reduction in genetic diversity. In Dam Rong population, the genetic diversity of older group (HeDR O = 0.204; PPBDR O = 75.2 %) was equal to younger group (HeDR Y = 0.209; PPBDR Y = 72.7 %) and the intergroup gene differentiation was GSTDR = 0.0304 with the genetic distance between them was DDR O-Y = 0.01393 showed the stability in genetic diversity. Data for genetic diversity and variation from this study can be used to further investigate and protect this variety for conservation and development purposes and for sustainable exploiting and use of these valuable natural resources.
Cloning of sucrose isomerase encoding gene from Klebsiella singaporensis ISB-36 and its expression in Pichia pastoris
Authors: Bach Cao Xuan , Thi Kim Anh Dang , Thanh Thuy Nguyen , Tu Anh Truong , Thi Dieu Linh Nguyen , Nguyen Thanh Vu 
Published: November 2020

Given potential health benefits including low glycemic index, tooth friendly, suitable to infants, elderly and diabetic patients, isomaltulose was considered as a promising alternative sweetener to sucrose. Due to the presence of liposaccharide endotoxin in Serratia plymuthica CBS 574.44, a Gram-negative bacterium, and minute amount of formaldehyde carried over, purification of isomaltulose requires rigorous controls in industry. To reduce the cost associated with product purification, here we propose the use of recombinant enzyme in isomaltulose production. The mature gene coding for sucrose isomerase synthase (K.SI36.PalI) from Klebsiella singarporensis ISB 36, which isolated from woodborer in Vietnam, was expressed in Pichia pastoris X33. The nucleotide sequence of K.SI36.PalI gene was similar to AY040843.1 of Klebsiella sp. LX3 except one nucleotide C1025 in AY040843.1 replaced by T1025 in K.SI36.PalI. This leads to single amino acid difference in deduced protein sequence (from 342Ser to 342Phe). Furthermore, the addition of two amino acids (Glu and Phe) was observed at N-terminus. The calculated molecular weight of sucrose isomerase from K.SI36.PalI was 67.46 kDa and the pI was 6.55. There was one potential glycosylation site at 466Asn. The maximum sucrose isomerase activity in the culture broth reached 36,6 U.mL-1in 1 L shake-flask. The purified recombinant enzyme was most active at 40°C and pH 7.0. At the optimum condition, within 6 hours, the enzyme converted 94% of sucrose in a 40% sucrose solution into isomaltulose. This was the first study on the expression of sucrose isomerase synthase gene in P. pastoris, and the results showed the efficient conversion of sucrose isomerase recombinant.
Hepsidinin anne sütü demir düzeyi üzerine etkisi
Authors: DURSUN Adem , KILIÇ DOKAN Fatma , ELMALI Ferhan , MUHTAROĞLU Sebahattin , KONDOLOT Meda , ÖZDEMİR Mehmet Akif 
Published: November 2020

Amaç: Demir tüm canlıların büyüme ve gelişmesi için son derece önemli
olan bir elementtir. Özellikle ilk 6 aylık dönemde infantlar için tek demir
kaynağı anne sütü olduğundan anne sütünün demir konsantrasyonu ve buna etki
eden faktörleri belirlemek önemlidir. Bu çalışmada annenin demir durumunun,
hepsidin düzeyinin ve anne sütüne geçen demir miktarı üzerine etkisi araştırılmıştır.

Materyal–Metod: Bu çalışma Mayıs 2013 Kasım 2013 tarihleri arasında Erciyes Üniversitesi Tıp
Fakültesi Çocuk Hastanesine başvuran bebeklerin annelerinden süt ve kan
örnekleri alınarak yapıldı. Çalışmada herhangi bir sağlık problemi olmayan,
yaşları 18 ile 36 arasında değişen, laktasyonun 15. gün ile 18. ay arasında
olan ve matür bebek doğuran toplam 240 anneden, 08.00-12.00 saatleri arasında süt ve kan numuneleri alındı.

Bulgular: Çalışma grubu hemoglobin, serum demir ve
ferritin düzeylerinin normal ve düşük oluşuna göre alt gruplara ayrıldı.
Annelerin 194 ünün (%80.8) hemoglobin
değeri normal, 46 sının (%19.2) düşük bulundu. Serum demir düzeyine göre
sınıflandırıldığında 170 annenin (% 70.8) demir düzeyininin normal, 70 annenin
(% 29.2) düşük olduğu tespit edildi. Ferritin düzeylerine göre
değerlendirildiğinde 140 annenin (% 58.3) ferritin düzeyinin normal,100 annenin
(% 41.7) ferritin düzeyinin düşük olduğu görüldü. Hemoglobin, serum demir ve
ferritin ile anne sütü demir konsantrasyonu arasında bir ilişki görülmedi.
Hepsidin ile anne sütü demiri arasında pozitif bir korelasyonun olduğu dikkat
çekti. Hemoglobin, serum demir ve ferritin düzeylerine göre ayrılan
grupların anne sütü demir konsantrasyonları benzer bulundu. Hepsidin düzeyi
yüksek olan grubun anne sütü demir konsantrasyonunun daha yüksek olduğu tespit
edildi.

Sonuç: Annenin demir
durumu anne sütüne geçen demir düzeyini
etkilemez. Hepsidin yalnızca
intestinal demir emiliminde değil aynı zamanda meme dokusunda da demir regülasyonundan
sorumlu olan ve süte demir geçişinde etkili olan bir hormondur
Epicardial fat Tissue Volumetry: Comparison of Semi-Automatic Measurement and the Machine Learning Algorithm
Authors: Chernina V. Y. , Pisov M. E. , Belyaev M. G. , Bekk I. V. , Zamyatina K. A. , Korb T. A. , Aleshina O. O. , Shukina E. A. , Solovev A. V. , Skvortsov R. A. , Filatova D. A. , Sitdikov D. I. , Chesnokova A. O. , Morozov S. P. , Gombolevsky V. A. 
Published: November 2020

Aim To compare assessments of epicardial adipose tissue (EAT) volumes obtained with a semi-automatic, physician-performed analysis and an automatic analysis using a machine-learning algorithm by data of low-dose (LDCT) and standard computed tomography (CT) of chest organs.Material and methods This analytical, retrospective, transversal study randomly included 100 patients from a database of a united radiological informational service (URIS). The patients underwent LDCT as a part of the project “Low-dose chest computed tomography as a screening method for detection of lung cancer and other diseases of chest organs” (n=50) and chest CT according to a standard protocol (n=50) in outpatient clinics of Moscow. Each image was read by two radiologists on a Syngo. via VB20 workstation. In addition, each image was evaluated with a developed machine-learning algorithm, which provides a completely automatic measurement of EAT.Results Comparison of EAT volumes obtained with chest LDCT and CT showed highly consistent results both for the expert-performed semi-automatic analyses (correlation coefficient >98 %) and between the expert layout and the machine-learning algorithm (correlation coefficient >95 %). Time of performing segmentation and volumetry on one image with the machine-learning algorithm was not longer than 40 sec, which was 30 times faster than the quantitative analysis performed by an expert and potentially facilitated quantification of the EAT volume in the clinical conditions.Conclusion The proposed method of automatic volumetry will expedite the analysis of EAT for predicting the risk of ischemic heart disease.
Evaluasi Produktivitas Padi Transgenik Rojolele yang Potensial Tahan Penggerek Batang Padi Kuning Scirpophaga incertulas Wlk
Authors: Nurhasanah Ade Nena , Zahra Fatimah , Estiati Amy , Usyati Usyati , Pantouw Carla Frieda , Maulana Budi Satrio , Hidayatv Muhammad Taufik , Nugroho Satya 
Published: November 2020

Rice yellow stem borer (YSB, Scirpophaga incertulas Wlk) is one of the most damaging rice pests in Indonesia, especially in rice growing centers in West Java. Because there is no source of resistance genes in rice or its close relatives, resistant improvement by genetic engineering is one strategy to obtain resistant rice cultivar. Previously, the cryIB::cryIAa fusion gene from Bacillus thuringiensis has been introduced into the Rojolele variety to obtain 6 transgenic rice events resistant to YSB (X22, U10, W3, Y7, Q20, and P8) and has been tested for resistance in greenhouses. This study was aimed to evaluate the transgenic rice productivity carried out in a confined field trial in field station belonging to the Center for Rice Research in Sukamandi, Subang, West Java. The procedure for the field testing followed the 1998 Guidelines for Biosafety Testing of Agricultural Biotechnology Products: Plant Seri by the Ministry of Agriculture. The parameters observed were agronomic characters (plant height, number of tillers, and number of panicles) and yield components (number of filled grains per panicle, number of empty grains per panicle, panicle length, and weight of 1000 grains). The yield was also measured by dry grain yield. The results indicated that the performance were varied among the 6 events tested. Rice events X22, W3, Y7, and P8 showed agronomic characteristics and yield components resembled Rojolele varieties, and performed well under field condition. X22 and W3 showed closest resemblance to Rojolele in terms of yield potential.
Keywords: confined field trial, cryIB::cryIAa, production, rice yellow stem borrer, rojolele rice, transgenic