bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insights on intermolecular FMN-heme domain interaction and the role of linker length in cytochrome P450cin fusion proteins
Authors: Belsare Ketaki D. , Ruff Anna Joëlle , Martinez Ronny , Schwaneberg Ulrich 
Published: June 2020

AbstractCytochrome P450s are an important group of enzymes catalyzing hydroxylation, and epoxidations reactions. In this work we describe the characterization of the CinA–CinC fusion enzyme system of a previously reported P450 using genetically fused heme (CinA) and FMN (CinC) enzyme domains fromCitrobacter braaki. We observed that mixing individually inactivated heme (-) with FMN (-) domain in the CinA-10aa linker - CinC fusion constructs results in recovered activity and the formation of (2S)-2β-hydroxy,1,8-cineole (174 µM), a similar amount when compared to the fully functional fusion protein (176 µM). We also studied the effect of the fusion linker length in the activity complementation assay. Our results suggests an intermolecular interaction between heme and FMN parts from different CinA–CinC fusion protein similar to proposed mechanisms for P450 BM3 on the other hand, linker length plays a crucial influence on the activity of the fusion constructs. However, complementation assays show that inactive constructs with shorter linker lengths have functional subunits, and that the lack of activity might be due to incorrect interaction between fused enzymes.
Predictors of puberty-related health behaviors among girl adolescents in Chahar Mahal Bakhtiari
Authors: Sakineh Rakhshanderou , Mohtasham Ghaffari , Ali Ramezankhani , Leila Gholami Dastenaee 
Published: June 2020

Abstract

Introduction
It is important to recognize the various dimensions of puberty and planning for the education of adolescents and their parents who are on the verge of this course. The present study aimed to investigate predictors of puberty health behavior in adolescent girls.

Materials & Methods
This correlational study was carried out on 280 female students from the eighth and ninth grades of high school who were selected by multi-stage random sampling method. The data gathering tool was a researcher-made questionnaire whose validity was assessed using the face and content validity method (Panel view of the experts) and its reliability was tested by test-retest and internal consistency. The collected data were analyzed by SPSS 16 using descriptive statistics, Pearson correlation coefficient and multiple regression at a significant level less than 0.05.

Results
Regression results with stepwise analysis showed that demographic variables other than the age of students (p = 0.031) had no effect on the adoption of puberty health behaviors, but their students’ knowledge and their attitude were good predictors of behaviors Health is puberty. Among the underlying and psychological variables, was the strongest prediction (Beta = 0.48). Attitude with knowledge and age was 34.9% of variance for explaining puberty health behaviors in adolescents.

Conclusion
Considering the power of predictors such as knowledge and attitude, it is possible to develop puberty health behaviors by increasing knowledge of students and providing correct and appropriate information to them and improving attitudes.
The necessity of education about reproductive health of female adolescents to mothers in Iran: a qualitative study
Authors: Salehin Shahrbanoo , Simbar Masoumeh , Keshavarz Zohre , Nasiri Malihe 
Published: June 2020

Abstract

Objectives
Parents are challenged to provide the required information about reproductive issues for their adolescents. The study aims to explain women’s perception of the necessity of education about adolescent girls, reproductive health to mothers.

Methods
This research is a qualitative content analysis. Sampling was performed using purposeful sampling to saturation of data. The study sample included 26 mothers and 14 key informants. To collect data, semi-structured interviewing was used. Data trustworthiness was verified based on Lincoln and Guba’s criteria and the data was analyzed using conventional content analysis with MAXQDA10 software.

Results
Four themes and 13 main categories each with some subcategories were extracted in this research. The themes and categories included: “risky social-environmental factors (existence of inappropriate educational resources, a challenge between tradition and modernity in the society, social harms, and educational barriers)”, weakness in awareness, attitude, and family relationships (mother's limited awareness, mother's negative attitude, improper interaction between the parents and the adolescent in the family, and lack of discussion about sexual and reproductive matters in the family), problems associated with sexual and reproductive health of adolescent girls (puberty changes, insufficient perception, and understanding of the process of puberty and harms arising from early education), and high-risk behaviors of adolescents and their consequences (the adolescent's maladaptive behaviors and their outcomes).

Conclusion
The results of this research necessitate education of adolescent girls' reproductive health to mothers.
Effect of a school-based intervention in eating habits among school children: quasi experimental study, Tunisia
Authors: Ben Cheikh Asma , Maatoug Jihène , Ghammam Rim , Chouikha Firas , Mallat Amal , Ghannem Hassen 
Published: June 2020

AbstractObjectiveThe present study aimed to assess whether six months intervention program with parents' implication in primary schools is able to decrease morning snack consumption among children aged 6–12 years.MethodsWe carried out a quasi-experimental study with two groups of schoolchildren in the region of Sousse (Tunisia) from 2015 to 2016. One primary school in each group was selected. In each school, we randomly selected a sample size of schoolchildren and their parents. The intervention was based on healthy eating habits promotion.ResultsThe consumption of morning snacks the day before data collection, reported by children, decreased significantly in post-intervention in both intervention and control groups.The decrease of consumption of morning snacks was significantly higher in intervention group (p=0.009). According to parents, the proportion of children who had the habit of eating morning snack decreased significantly from pre to post-intervention in intervention group (p<0.001).ConclusionA healthy environment should be created through effective school policies to prevent obesity.
Comparing self-perceived global self-esteem and physical self-esteem among children and adolescents in Southeastern Sweden, investigated in 2000 and 2017
Authors: Raustorp Anders , Fröberg Andreas 
Published: June 2020

Abstract

Objectives
To compare self-perceived global self-esteem (GSE) and physical self-esteem (PSE) among children and adolescents aged 11 and 14 years in Southeastern Sweden, investigated in 2000 and 2017.

Methods
The present study consists of two independent cross-sectional study-cohorts from Southeastern Sweden, investigated in 2000 and 2017. The same protocol, procedures, and instruments were used in 2000 and 2017. In October 2000, data for self-perceived GSE and PSE, and anthropometry were collected from 11-years old children (Grade 5) (n=74) and 14-years old adolescents (Grade 8) (n=84). In October 2017, children (n=186) and adolescents (n=140) from the same grade-levels, schools and classrooms provided data for the same variables as in 2000. GSE and PSE were assessed with the Children and Youth Physical Self-Perception Profile (CY-PSPP).

Results
Self-perceived GSE was higher in 2017 as compared to 2000 among both 11-years old boys (p<0.001) and girls (p<0.001) and 14-years old boys (p=0.008) and girls (p<0.001). Similarly, self-perceived PSE was higher in 2017 as compared to 2000 among both 11-years old boys (p<0.001) and girls (p=0.023) and 14-years old boys (p=0.025) and girls (p=0.002).

Conclusions
Self-perceived GSE and PSE among children and adolescents aged 11 and 14 years in Southeastern Sweden were higher in 2017 as compared to 2000. These results are not in agreement with the increased psychological ill-health as being reported among children and adolescents during the last decade in Sweden.
Stressful life events and depressive symptoms among adolescents in Malaysia: the mediating role of maladaptive cognitive schema
Authors: Wong Yi Shan , Zulkefly Nor Sheereen , Tan Kit-Aun 
Published: June 2020

Abstract

Objectives
The present study aimed to examine the mediational role of maladaptive cognitive schema in the association between stressful life events, which are operationalised as major (i. e. negative life events) and minor (i. e. daily hassles) life stressors, and depressive symptoms among adolescents.

Methods
A cross-sectional correlational study was conducted to recruit participants across four selected states of Kedah, Kelantan, Melaka and Selangor in Peninsular Malaysia. This study involved a total of 1,032 adolescents from 25 government secondary schools, identified using probability proportional to size cluster sampling technique. Data were collected through a self-report questionnaire.

Results
Using structural equation modelling analyses, findings revealed a full mediation effect of maladaptive cognitive schema between negative life events and depressive symptoms, and a partial mediation effect between daily hassles and depressive symptoms.

Conclusions
This study provided valuable insights about the significance of maladaptive cognitive schema as a mediator in the stress-depression association and advanced the understanding of mechanism underlying development of depressive symptoms among adolescents in Malaysia. Findings also benefit the clinical practice in the development of targeted depression prevention and intervention programs.
Predictors of health practices among a group of Iranian adolescent pregnant women: a cross-sectional study
Authors: Hadian Tahereh , Sanaz Moosavi , Shahla Meedya , Sakineh Mohammad-Alizadeh-Charandabi , Eesa Mohammadi , Mojgan Mirghafourvand 
Published: June 2020

Abstract

Introduction
The health practices of pregnant women can affect maternal and fetal health, and pregnancy outcomes. Understanding the predictors of health practices in adolescent pregnant women can help improve these practices. The present study aimed to determine the predictors of health practices in adolescent pregnant women.

Materials and methods
This cross-sectional study was conducted on 316 adolescent pregnant women in health centers of Tehran (capital of Iran). The participants were selected through the census method. The data were collected using the socio-demographic, obstetrics and health practices questionnaires and analyzed using Pearson correlation coefficient, independent t-test, one-way ANOVA, and general linear model.

Results
The mean score of health practice was 135.29 ± 9.08, ranging from 34 to 170. The highest and the lowest mean score pertained to the avoidance of harmful drugs and opiates subscale (29.79) and the balance of rest and exercise subscale (13.15), respectively. The general linear model showed that a lower level of education, a history of abortion, lack of involvement in pre-pregnancy counseling, and delayed attendance for prenatal care, reduced the health practice score. However, high level of emotional support from the spouse increased the health practice score.

Conclusions
The findings highlighted the factors effective on health practices including involvement in pre-pregnancy counseling, early prenatal care and emotional support for the adolescent pregnant woman.
Structural dependence of transmission characteristics for photonic crystal fiber with circularly distributed air-holes
Authors: Mondal Kajal 
Published: June 2020

Abstract
In this study, design and transmission characteristics of a special type of photonic crystal fiber (PCF) geometry namely, circular-lattice photonic crystal fiber (C-PCF) structure are presented. The cladding of the structure consists by a cylindrically symmetrical distribution of air-holes in the silica background and the core is created by omitting one air-hole at the center. The structure provides high degree of flexibility in the fiber design and hence tailorable modal properties. Structural dependence of transmission characteristics of the geometry is numerically investigated by using finite difference mode convergence algorithm. The wavelength responses of fiber parameters, such as effective refractive index, chromatic dispersion, mode-effective area, and nonlinear coefficient of the structure are systematically investigated. Besides, effective V-parameter and single-mode operation of the fiber are also evaluated and discussed. The simulation results show the possibility of large negative dispersion and dispersion flattened nature of the geometry.
Die Stellung von Religion im politischen Denken des Aristoteles
Authors: Piepenbrink Karen 
Published: June 2020

ZusammenfassungDer vorliegende Aufsatz geht der Frage nach, aus welchen Gründen religiöse Aspekte im politischen Denken des Aristoteles – verglichen mit dem anderer zeitgenössischer Philosophen wie auch mit der politischen Praxis seiner Zeit – nicht prominent vertreten sind. Dabei beleuchtet er insbesondere den Umstand, dass Aristoteles der sozialintegrativen wie auch der identitätsstiftenden Funktion des Kultes im Hinblick auf die Polisgemeinschaft keine zentrale Bedeutung beimisst. Der Beitrag deutet dies auf dem Hintergrund der spezifischen Fragestellungen wie auch der politischen Prämissen des Philosophen, darunter seine Fokussierung der Stasisproblematik und der Arm-Reich-Dichotomie. Angesichts dessen gelangt Aristoteles – abweichend von vielen seiner Zeitgenossen – zu der Einschätzung, dass sich soziale Kohäsion vorrangig durch das Austarieren konkurrierender Ansprüche fördern lässt, weniger durch Rekurse auf gemeinschaftsstiftende religiöse Vorstellungen oder kollektive Kultpraktiken.
Parents’ Awareness and Involvement in Dealing with Cyberbullying
Authors: Tal Tamir , Prebor Gila 
Published: June 2020

AbstractThe purpose of this study is to examine the extent to which parents of children aged 10–12 are aware that cyberbullying is a widespread phenomenon, how they deal with acts of cyberbullying performed by or toward their child, whether they take active steps toward preventing cyberbullying by and/or toward their child, and to what extent they are willing to invade their child’s privacy to this end.The study employs a quantitative methodology. One hundred and thirty-three parents were selected from a convenient sample of parents of children in grades 4–6 in a number of public elementary schools. It was found that most parents have heard about cyberbullying, mainly through the various media and not as a result of communicating with their child. Although parents understand that there are psychological effects on victims and criminal consequences for aggressors, most do not deepen their knowledge on the issue. Most parents assume that they can control the phenomenon and distance their child from it and that their child was not involved in cyberbullying. These findings contrast with findings from other studies indicating that most children were involved in cyberbullying to a certain degree. Identifying the reason behind this gap and ways to decrease it requires further investigation.Many studies have focused on cyberbullying among adolescents (ages 13–17) and less so on children aged 10–12. In this study, we chose to focus on children aged 10–12 because evidence indicates that children in this age group are more exposed to the phenomenon.
Facile synthesis of sulfur@titanium carbide Mxene as high performance cathode for lithium-sulfur batteries
Authors: Zhang Fan , Zhou Yunlei , Zhang Yi , Li Dongchan , Huang Zhichao 
Published: June 2020

Abstract
The design of sulfur hosts with polar, sulfurphilic, and conductive network is critical to lithium-sulfur (Li-S) batteries whose potential applications are greatly limited by the lithium polysulfide shuttle effect. Mxenes, possessing layered-stacked structures and high electrical conductivities, have a great potential in sulfur hosts. Herein, sulfur nanoparticles uniformly decorated on titanium carbide Mxene (S@Ti3C2Tx Mxene) are synthesized via a hydrothermal method and then utilized as a cathode for lithium-sulfur batteries. This unique architecture could accommodate sulfur nanoparticles expansion during cycling, suppress the shuttling of lithium polysulfide, and enhance electronical conductivity. Consequently, the S@Mxene with a high areal sulfur loading (∼4.0 mg cm−2) exhibits a high capacity (1477.2 mAh g−1) and a low capacity loss per cycle of 0.18% after 100 cycles at 0.2 C. This work may shed lights on the development of high performance sulfur-based cathode materials for Li-S batteries.
Metal-insulator-metal nanoresonators – strongly confined modes for high surface sensitivity
Authors: Duffett George , Wirth Ralph , Rayer Mathieu , Martins Emiliano R. , Krauss Thomas F. 
Published: June 2020

Abstract
Photonic and plasmonic refractive index sensors are able to detect increasingly smaller refractive index changes and concentrations of clinically relevant substances. They typically exploit optical resonances and aim to maximise the field overlap with the analyte in order to achieve high sensitivity. Correspondingly, they operate on the basis of maximizing the bulk sensitivity, which favours spatially extended modes. We note that this strategy, counter-intuitively, is not necessarily suitable for detecting biomolecules and one should focus on the surface sensitivity instead. Here, we show that by confining light tightly in metal-insulator-metal (MIM) nanoresonators, the surface sensitivity is significantly increased despite a clear decrease in bulk sensitivity. In particular, we experimentally show the operation of third order MIM resonators which support both extended surface plasmon polariton (SPP) modes and localized MIM modes. We are able to demonstrate that the MIM mode has a sensitivity of 55 nm/RIU to a 10 nm layer, which is approximately twice as high as that of the SPP mode. Overall, our work emphasizes the importance of the surface sensitivity over the more commonly used bulk sensitivity and it shows a novel approach for improving it. These insights are highly relevant for the design of next generation optical biosensors.
Crystal structure of [(bis(1,10-phenanthroline-κ2
N,N′)-(2-carboxy-4-(3-carboxy-5-carboxylatophenoxy)benzoato-κ2O:O′))nickel(II) monohydrate, (1,10-phenanthroline-κ2
N:N′)-(μ2-(5-(3′,4′-dicarboxylphenoxy)-isophthalate-κ2O:O′))nickel(II)], C40H24N4O9Ni ⋅ H2O
Authors: Yao Li-Ping 
Published: June 2020

Abstract
C40H26N4O10Ni, triclinic, P1̄ (no. 2), a = 11.5851(8) Å, b = 11.5875(7) Å, c = 13.3921(8) Å, α = 81.440(5)°, β = 77.913(6)°, γ = 76.014(6)°, V = 1696.65(18) Å3, Z = 2, R
gt(F) = 0.0516, wR
ref(F
2) = 0.1203, T = 293(2) K.
The Discarded Mind: From Divine Ideas to Secular Concepts
Authors: Orr James 
Published: June 2020

Summary
This article proposes an overdue corrective to declinist genealogies of modernity that trace a trajectory from the participatory ontology of late-antique and high-scholastic metaphysics – in which created reality is taken to exemplify patterns in God’s creative blueprint – to a nominalist ontology of discrete, singular particulars whose unity and intelligibility is grounded only in the linguistic capacities of the human subject. It does so by advancing two connected historical claims. First, the shift should be understood less in terms of the substitution of universals for vocal signifiers, as historical accounts of the rise of nominalism have tended to argue, but rather in terms of the slow substitution of divine ideas for human concepts. Second, from the earliest origins of the split between continental and analytic philosophy, the shift from divine intellectualism to secular conceptualism generated sceptical threats both for the phenomenological tradition – crystallized most dramatically in the dilemma of ‘correlationism’ that variously occupies Husserl, Merleau-Ponty, and Quentin Meillassoux – but equally acutely for analytic metaphysics, from Frege’s concepts and Russell’s universals to Michael Dummett’s semantic verificationism. The article concludes that for all the differences between these stances, they are forms of ersatz participatory realism that each endorse an intellectualist account of reality free of the theological commitments that once underpinned it, even though this came at the cost of a wholesale rejection of realism.
Adaptive magnetic suspension anti-rolling device based on frequency modulation
Authors: Gao Sumei , Xu Longxiang , Jin Chaowu , Chen Qianwei 
Published: June 2020

AbstractJoint stabilizers and new technology stabilizers are hotspots of ship stabilizing technology research at the present stage. This study proposes a magnetic suspension stabilizing method; expounds the working principle of magnetic suspension stabilization, respectively; establishes the mathematical model of the magnetic suspension stator and the stabilization mass block and the mathematical model of magnetic stabilizer and ship; and stimulates the displacement, velocity, and acceleration. On the basis of the simulation, a set of magnetic suspension stabilizers have been designed; the stability of suspension has been tested; and, respectively, the acceleration value of stator and stabilization mass block has been measured by loading 0–500 Hz sine voltage excitation signal on electromagnetic coil; thus, the feasibility of the magnetic suspension stabilizer has been verified.
Chemogenetic Suppression of GnRH Neurons during Pubertal Development Can Alter Adult GnRH Neuron Firing Rate and Reproductive Parameters in Female Mice
Authors: Dulka Eden A. , DeFazio R. Anthony , Moenter Suzanne M. 
Published: June 2020

AbstractGonadotropin-releasing hormone (GnRH) neurons control anterior pituitary, and thereby gonadal, function. GnRH neurons are active before outward indicators of puberty appear. Prenatal androgen (PNA) exposure mimics reproductive dysfunction of the common fertility disorder polycystic ovary syndrome (PCOS) and reduces prepubertal GnRH neuron activity. Early neuron activity can play a critical role in establishing circuitry and adult function. We tested the hypothesis that changing prepubertal GnRH neuron activity programs adult GnRH neuron activity and reproduction independent of androgen exposure in female mice. Activating (3Dq) or inhibitory (4Di) designer receptors exclusively activated by designer drugs (DREADDs) were targeted to GnRH neurons using Cre-lox technology. In control studies, the DREADD ligand clozapine n-oxide (CNO) produced the expected changes in GnRH neuron activityin vitroand luteinizing hormone (LH) releasein vivo. CNO was administered to control or PNA mice between two and three weeks of age, when GnRH neuron firing rate is reduced in PNA mice. In controls, reducing prepubertal GnRH neuron activity with 4Di increased adult GnRH neuron firing rate and days in diestrus but did not change puberty onset or GABA transmission to these cells. In contrast, activating GnRH neurons had no effect on reproductive parameters or firing rate and did not rescue reproductive phenotypes in PNA mice. These studies support the hypothesis that prepubertal neuronal activity sculpts elements of the adult reproductive neuroendocrine axis and cyclicity but indicate that other PNA-induced programming actions are required for full reproductive phenotypes and/or that compensatory mechanisms overcome activity-mediated changes to mitigate reproductive changes in adults.