bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic ability of maximum blink interval together with Japanese version of Ocular Surface Disease Index score for dry eye disease
Authors: Hirosawa Kunihiko , Inomata Takenori , Sung Jaemyoung , Nakamura Masahiro , Okumura Yuichi , Midorikawa-Inomata Akie , Miura Maria , Fujio Kenta , Akasaki Yasutsugu , Fujimoto Keiichi , Zhu Jun , Eguchi Atsuko , Nagino Ken , Kuwahara Mizu , Shokirova Hurramhon , Yanagawa Ai , Murakami Akira 
Published: October 2020

AbstractVarious symptoms of the dry eye disease (DED) interfere with the quality of life and reduce work productivity. Therefore, screening, prevention, and treatment of DED are important. We aimed to investigate the potential diagnostic ability of the maximum blink interval (MBI) (the length of time participants could keep their eyes open) with disease-specific questionnaire for DED. This cross-sectional study included 365 patients (252 with DED and 113 without DED) recruited between September 2017 and December 2019. Discriminant validity was assessed by comparing the non-DED and DED groups based on the MBI with a Japanese version of the Ocular Surface Disease Index (J-OSDI) and tear film breakup time (TFBUT) with J-OSDI classifications. The MBI with J-OSDI showed good discriminant validity by known-group comparisons. The positive and predictive values of MBI with J-OSDI were 96.0% (190/198 individuals) and 37.1% (62/167 individuals), respectively. The area under the receiver operating characteristic curve (AUC) of MBI with J-OSDI was 0.938 (95% confidence interval 0.904–0.971), the sensitivity was 75.4% (190/252 individuals), and the specificity was 92.9% (105/113 individuals), which are similar to the diagnostic ability of TFBUT with J-OSDI (AUC 0.954). In conclusion, MBI with J-OSDI may be a simple, non-invasive screening test for DED.
Characterization of rare spindle and root cell transcriptional profiles in the stria vascularis of the adult mouse cochlea
Authors: Gu Shoujun , Olszewski Rafal , Taukulis Ian , Wei Zheng , Martin Daniel , Morell Robert J. , Hoa Michael 
Published: October 2020

AbstractThe stria vascularis (SV) in the cochlea generates and maintains the endocochlear potential, thereby playing a pivotal role in normal hearing. Knowing transcriptional profiles and gene regulatory networks of SV cell types establishes a basis for studying the mechanism underlying SV-related hearing loss. While we have previously characterized the expression profiles of major SV cell types in the adult mouse, transcriptional profiles of rare SV cell types remained elusive due to the limitation of cell capture in single-cell RNA-Seq. The role of these rare cell types in the homeostatic function of the adult SV remain largely undefined. In this study, we performed single-nucleus RNA-Seq on the adult mouse SV in conjunction with sample preservation treatments during the isolation steps. We distinguish rare SV cell types, including spindle cells and root cells, from other cell types, and characterize their transcriptional profiles. Furthermore, we also identify and validate novel specific markers for these rare SV cell types. Finally, we identify homeostatic gene regulatory networks within spindle and root cells, establishing a basis for understanding the functional roles of these cells in hearing. These novel findings will provide new insights for future work in SV-related hearing loss and hearing fluctuation.
Cobalt can fully recover the phenotypes related to zinc deficiency inSalmonellaTyphimurium
Authors: Ammendola Serena , Ciavardelli Domenico , Consalvo Ada , Battistoni Andrea 
Published: October 2020

AbstractCobalt is an essential element for living systems, which, however, make very limited use of this metal, using it mainly in cobalamin-containing enzymes. The reduced use of cobalt compared to other transition metals is generally attributed to the potential toxicity of this element. In this work, we demonstrate that cobalt not only does not have an obvious toxic effect on Salmonella Typhimurium, but that it can efficiently compensate for zinc deficiency in a znuABC deleted strain. In fact, cobalt, but not cobalamin supplementation, rescued all major phenotypic defects of the znuABC strain, including the reduced ability to grow and swim in zinc-deficient media and the high susceptibility to hydrogen peroxide stress. Growth in a cobalt-supplemented defined medium led to the accumulation of large amounts of cobalt both in the wild type and in the znuABC strain. These data suggest that atoms of cobalt may be incorporated in bacterial proteins in place of zinc, ensuring their functionality. In support of this hypothesis we have shown that, in vivo, cobalt can accumulate in ribosomes and replace zinc in a periplasmic Cu,Zn superoxide dismutase (SodCII). Finally, we provide evidence of the ability of cobalt to modulate the intracellular concentration of zinc-regulated proteins (ZnuA, ZinT, and SodCII). Although some observations suggest that in some proteins the replacement of zinc with cobalt can lead to subtle structural changes, the data reported in this study indicate that Salmonella has the ability to use cobalt instead of zinc, without evident harmful effects for cell physiology.
Progress in Education of Children With Disabilities in Zambia
Authors: Peele Muchinka Mbewe , Gill Cindy , Wainscott Sarah 
Published: October 2020

Purpose
The purpose of this review article is to review the progress made in the treatment and education of persons with disabilities in Zambia, to identify barriers that have hindered change and initiatives that have facilitated positive changes in Zambia, and to highlight the initial steps toward the establishment of the profession of speech-language pathology in Zambia.

Conclusions
There have been remarkable strides in the education of children with disabilities and the establishment of support for persons with disabilities since the Republic of Zambia became an independent nation in 1964. Zambia's limited resources, understanding of disabilities, and cultural and social barriers have hampered efforts to provide special services to children. Despite these challenges, many policies have been adopted and laws passed to protect the rights of those with disabilities, including access to quality equitable and inclusive education programs. Though implementation of the stated ideals has been difficult, and poverty continues in many areas, preparation of special education teachers and inclusion practices has improved. One vital service for children with disabilities, speech/language therapy, remains outside the new provisions. Speech therapy is not currently provided in the schools and is rarely available elsewhere. Though there are currently no Zambian college or university preparation programs for speech therapists, plans to bring speech pathology to Zambia are underway.
Performance enhancement of IEEE 802.15.4 by employing RTS/CTS and frame concatenation
Authors: Barroca Norberto , Velez Fernando J. , Borges Luís M. , Chatzimisios Periklis 
Published: October 2020

IEEE 802.15.4 has been widely accepted as the de facto standard for wireless sensor networks (WSNs). However, as in their current solutions for medium access control (MAC) sub‐layer protocols, channel efficiency has a margin for improvement, in this study, the authors evaluate the IEEE 802.15.4 MAC sub‐layer performance by proposing to use the request‐/clear‐to‐send (RTS/CTS) combined with frame concatenation and block acknowledgement (BACK) mechanism to optimise the channel use. The proposed solutions are studied in a distributed scenario with single‐destination and single‐rate frame aggregation. The throughput and delay performance is mathematically derived under channel environments without/with transmission errors for both the chirp spread spectrum and direct sequence spread spectrum physical layers for the 2.4 GHz Industrial, Scientific and Medical band. Simulation results successfully verify the authors’ proposed analytical model. For more than seven TX (aggregated frames) all the MAC sub‐layer protocols employing RTS/CTS with frame concatenation (including sensor BACK MAC) allow for optimising channel use in WSNs, corresponding to 18–74% improvement in the maximum average throughput and minimum average delay, together with 3.3–14.1% decrease in energy consumption.
Photoelectric properties of low temperature solution‐processed three‐dimensional Bi2S3 crystals
Authors: Yang Chunyan , Sun Yingying , Zhang Yaohua , Xiong Fei , Li Jianfeng , Zhang Peng , Tong Junfeng , Xia Yangjun 
Published: October 2020

Three‐dimensional Bi2S3 with different morphology of flower‐like, waxberry like and hydrangea like on the tin‐doped indium oxide substrate has been produced from one‐step aqueous solution at low temperature (40–70°C) and fixed pH of 0.81 for 24 h. The UV–vis measurement showed that the absorption spectrums of obtained Bi2S3 crystals were occurred blue shift compared to the bulk orthorhombic Bi2S3(1.3 eV). With the increase in temperature, the crystallinity of Bi2S3 films was gradually improved. When the temperature went to 55°C, the best conductivity was obtained.
Performance analysis of an on-site hydrogen facility for fuel cell trains
Authors: Piraino Francesco , Genovese Matteo , Fragiacomo Petronilla 
Published: October 2020

Fuel cell technologies and hydrogen can represent a potential and powerful enabler for replacing traditional diesel vehicles, especially in railways. In this train of thought, the present paper aims to investigate a fuel cell hybrid powertrain for a regional route. The main powertrain components are numerically modeled and the railway operations are simulated. The results achieved, in terms of power demand, efficiency and hydrogen consumption, are discussed and they are useful for properly sizing the refueling system. As a matter of fact, the train will be fueled with compressed hydrogen, produced on-site at a hydrogen central depot, where a hydrogen refueling station is thought to be installed. The hydrogen generation unit is considered to be a PEM unit, operating at 353 K and 20 bar. The produced hydrogen is then compressed by mean of a volumetric compressor and then stored in hydrogen tank type II, at 350 bar. The dispensing scheduling is based on the daily hydrogen demand required by the fuel cell-based train route, according to the railway timetable.
The system is indeed investigated from a technical point of view, proving the integration of such systems to represent a clean, sustainable, and flexible option.
Long-term observation of magnetic pulsations through the ELF Hylaty station located in the Bieszczady Mountains (south–eastern Poland)
Authors: Nieckarz Zenon , Michałek Grzegorz 
Published: October 2020

Ground-based measurements of ultra- and extremely low-frequency waves (ULF/ELF) carried out in 2005–2016 (the 23rd and 24th solar cycle) at the ELF Hylaty station in Bieszczady Mountains (south–eastern Poland) were used to identify the days (360 days) in which magnetic pulsation events (MPEs) occurred. To reveal sources of MPEs at the Sun we considered their correlation with the basic indices describing solar activity. Our analysis, like earlier studies, did not reveal a significant positive correlation between the MPE detection rate and the sunspot numbers (SSN). On the other hand, we showed that MPEs are strongly correlated (correlation coefficient ≈0.70) with moderate (Dst < −70 nT) and intense (Dst < −100 nT) geomagnetic disturbances expressed by the Disturbance Storm Index (Dst). We recognized all sources of these geomagnetic storms associated with the considered MPEs. Only 44% of the MPEs were associated with storms caused by CMEs listed in the CDAW LASCO CME catalog. 56% of the MPEs were associated with storms caused by other phenomena including corotating interaction regions (CIRs), slow solar wind or CMEs not detected by LASCO. We also demonstrated that the CMEs associated with the MPEs were very energetic, i.e. they were extremely wide (partial and halo events) and fast (with the average speed above 1100 km s−1). CMEs and CIRs generally appear in different phases of solar cycles. Because MPEs are strongly related to both of these phenomena they cannot be associated with any phase of a solar cycle or with any indicator characterizing a 11-year solar activity. We also suggested that the low number of MPEs associated with CMEs is due to the anomalous 24 solar cycle. During this cycle, due to low density of the interplanetary medium, CMEs could easily eject and expand, but they were not geoeffective.
Therapie mit kardialen implantierbaren elektrischen Devices im Alter
Authors: Israel Carsten W. 
Published: October 2020

ZusammenfassungDie Therapie mit Herzschrittmacher, implantierbarem Kardioverter-Defibrillator (ICD) oder kardialer Resynchronisation (CRT) ist bei Patienten im Alter besonders oft indiziert und hilfreich, stellt jedoch besondere Anforderungen an Indikationsstellung, Systemwahl, Implantation und Nachsorge. In der Schrittmachertherapie muss Einfühlungsvermögen angewandt werden, um eine oft unspezifische Symptomatik mit einer Bradykardie zu assoziieren. In der ICD-Therapie muss berücksichtigt werden, ob bei hohem Alter und Komorbidität eine Lebensverlängerung durch den ICD möglich und vom Patienten gewünscht ist. Bevor die Akutsituation nicht arrhythmischen Sterbens eintritt, sollte eine Deaktivierung der Schocktherapie erfolgen. Bei hohem Alter muss eine Implantation sicher und zügig durchgeführt, aber immer das optimale System (z. B. CRT) und eine optimale Elektrodenposition verwendet werden, da gerade alte Patienten sehr empfindlich auf eine suboptimale Hämodynamik reagieren.
Is it time for Cold-Endoscopic Submucosal Dissection? A feasibility study in an esophageal and colorectal live porcine model
Authors: Parra-Blanco Adolfo , Fraile-López Miguel 
Published: October 2020

Abstract
Background and study aims Use of cold endoscopic resection has increased due to excellent results with it and the ability to avoid electrosurgery related complications. The aim of this study was to evaluate the feasibility and safety of cold-endoscopic submucosal dissection (C-ESD) in an in vivo porcine model.
Patients and methods C-ESD with circumferential incision and submucosal dissection with a predominantly cold technique was tested in the esophagus and colorectum. Incision and dissection were attempted with a cold technique with a biopsy forceps and an endoscopic Maryland dissector. Large vessels were pre-coagulated with the latter device. Different traction methods were applied.
Results Twelve dissections were performed: four esophageal, four colonic, and four rectal. Tunnel and pocket methods were applied successfully. Full C-ESD was possible in the colorectum. In the esophagus, an initial incision had to be done with electrocautery. No major bleeding occurred. Two perforations occurred in the colon, one was endoscopically treated.
Conclusions Full C-ESD is feasible in the colorectum, whereas a small hot incision is needed in the esophagus. However, in 50 % of the colonic cases, there were perforations caused by the biopsy forceps making the circumferential incision. Therefore, potential benefits of endoscopic resection without cautery would warrant futures studies in humans initially in esophagus and rectal locations.
Hemostasis Laboratory Diagnostics: Characteristics, Communication Issues, and Current Challenges Resulting from Centralization of Laboratory Medicine
Authors: Scharf Rüdiger E. 
Published: October 2020

AbstractLaboratory diagnostics of patients with bleeding and thrombotic disorders can be a delicate task, which requires special skills and expertise. In this article, characteristic features of hemostasis testing are reviewed, including staged protocols and synoptic assessment of the patient history, clinical symptoms, and laboratory findings. Despite major progress in the diagnostic and therapeutic management, centralized testing of hemostasis can be associated with substantial challenges, resulting from the current dissociation between the clinical and laboratory world. To address some of these challenges, possible solutions are discussed, including adaptation of an established working paradigm.
Adenomas per colonoscopy and adenoma per positive participant as quality indicators for screening colonoscopy
Authors: Wang Shuo , Kim Adam S. , Church Timothy R. , Perdue David G. , Shaukat Aasma 
Published: October 2020

Abstract
Background and study aims Adenomas per colonoscopy (APC) and adenomas per positive patient (APP) have been proposed as additional quality indicators but their association with adenoma detection rate (ADR) is not well studied. The aim of our study was to evaluate the variability in APC and APP, their association with ADR, and associated risk factors in screening colonoscopies from a community practice.
Patients and methods We calculated the APC, APP, and ADR from all screening colonoscopies performed over 5 years. We used adjusted hierarchical logistic regression to assess the association of factors with APC, APP, and ADR.
Results There were 80,915 screening colonoscopies by 60 gastroenterologists. The median (Q1-Q3) APC, APP, and ADR were 0.41 (0.36 – 0.53), 1.33 (1.23 – 1.40), and 0.32 (0.28 – 0.38), respectively. Despite the high correlation between APC and ADR, 47.6 % of endoscopists with the lowest APC had a higher ADR, and no endoscopists with the highest APC had a lower ADR. Of endoscopists with the lowest APP, 74.3 % had a higher ADR and 5.6 % of endoscopists with the highest APP had a lower ADR. Factors associated with higher APC after multivariable adjustment included: older patients age (OR 1.003; 95 % CI 1.002 – 1.005), male patients (OR 1.123; 95 % CI 1.090 – 1.156), younger endoscopist age (OR 0.943; 95 % CI 0.941 – 0.945), and longer withdrawal time (OR 3.434; 95 % CI 2.941 – 4.010). Factors associated with higher APP were male sex, younger endoscopist age, and longer withdrawal time.
Conclusion APC and APP provides additional information about endoscopist performance. Younger endoscopist age and longer withdrawal time are associated with colonoscopy quality.
Reductive Ring-Opening 1,3-Difunctionalizations of Arylcyclopropanes with Sodium Metal
Authors: Yorimitsu Hideki , Wang Shuo , Kaga Atsushi 
Published: October 2020

AbstractSodium dispersion promotes reductive ring opening of arylcyclopropanes. The presence of a reduction-resistant electrophile, such as methoxypinacolatoborane, epoxide, oxetane, paraformaldehyde, or chlorotrimethylsilane, during the reductive ring opening event leads to the formation of 1,3-difunctionalized 1-arylalkanes by immediate trappings of the resulting two reactive carbanions. In particular, the ring-opening 1,3-diborylations of arylcyclopropanes afford 1,3-diborylalkanes with high syn selectivity.
Unravelling the Mysteries of the Mesentery
Authors: Gopalan Sunita , Raghu Vineetha 
Published: October 2020

AbstractThe mesentery and its folds tether the small bowel loops to the posterior abdominal wall. It transmits nerves, vessels, and lymph ensconced in a fatty sponge layer wrapped in a thin glistening peritoneum, from and to the small bowel. Not only does this flexible dynamic fatty apron house various localized primary benign and malignant lesions, it is often involved in and gives an indication of generalized or systemic diseases in the body. An understanding of the anatomy, components, and function of the mesentery helps to classify mesenteric abnormalities. This further allows for characterizing radiological patterns and appearances specific to certain disease entities. Recent reviews of mesenteric anatomy have kindled new interest in its function and clinical applications, heralding the possibility of revision of its role in diseases of the abdomen.
Two-Stage Pediatric Penile Reconstruction after Postcircumcision Gangrene
Authors: Zayid Tarek , Ouf Mohamed O. , Elbatawy Amr , Zidan Serag M. , Hamdy Abdelnaser , Ismail Hany , Sholkamy Khallad , Dahshan Hazem , Ayad Wael 
Published: October 2020

AbstractBackground Postcircumcision penile gangrene is a devastating complication that may lead to total or subtotal penile loss requiring penile reconstruction. Pediatric penile reconstruction poses diverse challenges for most plastic surgeon.Patients and Methods Retrospective cohort study of 12 children ranged from 6 to 36 months old suffered from total or partial penile loss secondary to electrocautery burn during circumcisions. Reconstruction was done by island groin flap for phallus in first stage and urethral reconstruction by tubularized scrotal flap 6 months later. The outcome was evaluated by assessment of flap survival, the esthetic appearance, urethral competence and rate of complication.Results Follow-up was ranged from 6 to 24 months. A new phallus of satisfactory dimensions was achieved in all cases. Complications included partial necrosis of the flap in two cases, fistulas in two cases, and stenosis of the urethral anastomosis in one case. These complications were successfully resolved by corrective surgery. Good satisfactory result regarded as shape and urination stream.Conclusion Penile reconstruction can be performed in children with good results and low complication rate. The use of island groin flap for phallus reconstruction followed by urethral reconstruction by tubularized scrotal flap 6 months later was found effective, time saving, and with minor complication.
Antibiotic Timing in Previable Prelabor Rupture of Membranes Less Than 24 Weeks of Gestation
Authors: Knupp Rubymel J. , Pederson Sarah , Blanchard Christina , Szychowski Jeff , Etikala Deepa , Sinkey Rachel , Wetta Luisa , Harper Lorie M. 
Published: October 2020

Objective This study aimed to compare neonatal and maternal outcomes between immediate and delayed prophylactic antibiotic administration after previable prelabor premature rupture of membranes (PROM) less than 24 weeks of gestation.Study Design Retrospective cohort study of singleton pregnancies with PROM between 160/7 and 236/7 weeks of gestational age conducted at a single tertiary care referral center between June 2011 and December 2015. Patients with multiple gestations, fetal anomalies, those who elected augmentation, or with a contradiction to expectant management, such as suspected intra-amniotic infection or stillbirth, were excluded from the study. We compared pregnancy characteristics, maternal complications, and neonatal outcomes between women who received a course of antibiotics within 24 hours of PROM and women who received antibiotics after 24 hours of PROM. The primary outcome was neonatal survival to hospital discharge. Secondary outcomes included gestational age at delivery, time from PROM to delivery, neonatal birth weight, days in the neonatal intensive care unit (NICU), composite adverse neonatal outcomes, and maternal morbidity.Results Ninety-four women met inclusion criteria, 57 (61%) received antibiotics within 24 hours of PROM and 37 (39%) received antibiotics 24 hours after PROM. Baseline maternal characteristics were similar in both groups. The mean gestational age at PROM was similar between groups at 20.8 ± 2.3 weeks in the immediate antibiotics group and 20.6 ± 2.1 weeks in the delayed antibiotics group (p = 0.48). Compared with delayed antibiotic administration, immediate antibiotic administration was not associated with a significant difference in latency time from PROM to delivery, rate of stillbirth, days in an ICU, or adverse neonatal outcomes. Maternal outcomes also did not differ significantly between groups. Neonatal birth weight was lower in the immediate antibiotics group (p = 0.012).Conclusion Our data suggest that there is no maternal or neonatal benefit to immediate administration of latency antibiotics compared with delayed administration.Key Points