bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extrinsic immune cell-derived, but not intrinsic oligodendroglial factors contribute to oligodendroglial differentiation block in multiple sclerosis
Authors: Starost Laura , Lindner Maren , Herold Martin , Xu Yu Kang T. , Drexler Hannes C. A. , Heß Katharina , Ehrlich Marc , Ottoboni Linda , Ruffini Francesca , Stehling Martin , Röpke Albrecht , Thomas Christian , Schöler Hans R. , Antel Jack , Winkler Jürgen , Martino Gianvito , Klotz Luisa , Kuhlmann Tanja 
Published: September 2020

AbstractMultiple sclerosis (MS) is the most frequent demyelinating disease in young adults and despite significant advances in immunotherapy, disease progression still cannot be prevented. Promotion of remyelination, an endogenous repair mechanism resulting in the formation of new myelin sheaths around demyelinated axons, represents a promising new treatment approach. However, remyelination frequently fails in MS lesions, which can in part be attributed to impaired differentiation of oligodendroglial progenitor cells into mature, myelinating oligodendrocytes. The reasons for impaired oligodendroglial differentiation and defective remyelination in MS are currently unknown. To determine whether intrinsic oligodendroglial factors contribute to impaired remyelination in relapsing–remitting MS (RRMS), we compared induced pluripotent stem cell-derived oligodendrocytes (hiOL) from RRMS patients and controls, among them two monozygous twin pairs discordant for MS. We found that hiOL from RRMS patients and controls were virtually indistinguishable with respect to remyelination-associated functions and proteomic composition. However, while analyzing the effect of extrinsic factors we discovered that supernatants of activated peripheral blood mononuclear cells (PBMCs) significantly inhibit oligodendroglial differentiation. In particular, we identified CD4+T cells as mediators of impaired oligodendroglial differentiation; at least partly due to interferon-gamma secretion. Additionally, we observed that blocked oligodendroglial differentiation induced by PBMC supernatants could not be restored by application of oligodendroglial differentiation promoting drugs, whereas treatment of PBMCs with the immunomodulatory drug teriflunomide prior to supernatant collection partly rescued oligodendroglial differentiation. In summary, these data indicate that the oligodendroglial differentiation block is not due to intrinsic oligodendroglial factors but rather caused by the inflammatory environment in RRMS lesions which underlines the need for drug screening approaches taking the inflammatory environment into account. Combined, these findings may contribute to the development of new remyelination promoting strategies.
Systematic review and meta-analysis of contemporary pancreas surgery with arterial resection
Authors: Rebelo Artur , Büdeyri Ibrahim , Heckler Max , Partsakhashvili Jumber , Ukkat Jörg , Ronellenfitsch Ulrich , Michalski Christoph W. , Kleeff Jörg 
Published: September 2020

Abstract
Objective
Advances in multimodality treatment paralleled increasing numbers of complex pancreatic procedures with major vascular resections. The aim of this meta-analysis was to evaluate the current outcomes of arterial resection (AR) in pancreatic surgery.

Methods
A systematic literature search was carried out from January 2011 until January 2020. MOOSE guidelines were followed. Predefined outcomes were morbidity, pancreatic fistula, postoperative bleeding and delayed gastric emptying, reoperation rate, mortality, hospital stay, R0 resection rate, and lymph node positivity. Duration of surgery, blood loss, and survival were also analyzed.

Results
Eight hundred and forty-one AR patients were identified in a cohort of 7111 patients. Morbidity and mortality rates in these patients were 66.8% and 5.3%, respectively. Seven studies (579 AR patients) were included in the meta-analysis. Overall morbidity (48% vs 39%, p = 0.1) and mortality (3.2% vs 1.5%, p = 0.27) were not significantly different in the groups with or without AR. R0 was less frequent in the AR group, both in patients without (69% vs 89%, p < 0.001) and with neoadjuvant treatment (50% vs 86%, p < 0.001). Weighted median survival was shorter in the AR group (18.6 vs 32 months, range 14.8–43.1 months, p = 0.037).

Conclusions
Arterial resections increase the complexity of pancreatic surgery, as demonstrated by relevant morbidity and mortality rates. Careful patient selection and multidisciplinary planning remain important.
Remote binding counts: measuring distractor-response binding effects online
Authors: Moeller Birte , Frings Christian 
Published: September 2020

AbstractBindings between stimulus- and response features have received increasing attention in recent research and theorizing regarding human action control. Apparently, very simple mechanisms that lead to feature binding and retrieval of recently integrated features have an important influence on planning and execution of actions. Regarding the importance of these mechanisms, it seems to be reasonable to test whether they can be measured outside of a formal laboratory situation. Here we ran an online version of the distractor-response binding task reaching participants via crowdsourcing. Distractor-response binding effects were significant in this setup showing that basic mechanisms of feature binding and retrieval indeed influence human action in less formal situations. Besides arguing for the generality and robustness of the effect practical implications are discussed.
Biological and technical complications in root cap–retained overdentures after 3–15 years in situ: a retrospective clinical study
Authors: Stalder Anja , Berger Camille Henriette , Buser Ramona , Wittneben Julia , Schimmel Martin , Abou-Ayash Samir 
Published: September 2020

AbstractObjectivesThis retrospective clinical study investigates the frequency of biological and technical complications in patients rehabilitated by natural root-retained overdentures (RODs) with cast post-and-cores (root caps) wearing precision attachments and analyses factors influencing complication rates (e.g. oral hygiene routines).Materials and methodsPatients formerly treated with RODs were invited for a cost-free clinical visit to evaluate their intraoral status. Furthermore, they were interviewed and patient records were screened for complications occurring since denture delivery. Statistical models include descriptive analyses, Fisher’s exact test, odds ratios, and a multivariate regression model.ResultsA total of 114 patients wearing 128 RODs with a total of 280 abutment teeth were evaluated (mean service time: 7.9 years). Technical complications occurred in 68.8% of the RODs, with matrix loosening being the most frequent complication (50.1%). Biological complications occurred in 53.9% of all RODs, with the presence of denture stomatitis being the most common biological complication (38.3%). The presence of denture stomatitis was significantly higher in the maxilla relative to the mandible (p = 0.0029), in subjects cleaning their dentures less than twice a day (p < 0.001), in subjects regularly using CHX-containing products (p = 0.036) and in subjects with a plaque index > 40% (p < 0.001).ConclusionsRoot cap-retained overdentures with precision attachments are a viable treatment option in partially dentate subjects, even over long-term periods. However, high complication rates should be expected.Clinical relevanceEstablishing good oral hygiene is a decisive factor in preventing complications in RODs. Furthermore, CHX-containing products may not be recommended for routine domestic use.
Modelling the cost-effectiveness of person-centred care for patients with acute coronary syndrome
Authors: Pirhonen Laura , Gyllensten Hanna , Fors Andreas , Bolin Kristian 
Published: September 2020

AbstractBackgroundPerson-centred care has been shown to be cost-effective compared to usual care for several diseases, including acute coronary syndrome, in a short-term time perspective (< 2 years). The cost-effectiveness of person-centred care in a longer time perspective is largely unknown.ObjectivesTo estimate the mid-term cost-effectiveness of person-centred care compared to usual care for patients (< 65) with acute coronary syndrome, using a 2-year and a 5-year time perspective.MethodsThe mid-term cost-effectiveness of person-centred care compared to usual care was estimated by projecting the outcomes observed in a randomized-controlled trial together with data from health registers and data from the scientific literature, 3 years beyond the 2-year follow-up, using the developed simulation model. Probabilistic sensitivity analyses were performed using Monte Carlo simulation.ResultsPerson-centred care entails lower costs and improved effectiveness as compared to usual care, for a 2-year time and a 5-year perspective. Monte Carlo simulations suggest that the likelihoods of the person-centred care being cost-effective compared to usual care were between 80 and 99% and between 75 and 90% for a 2-year and a 5-year time perspective (using a 500,000 SEK/QALY willingness-to-pay threshold).ConclusionsPerson-centred care was less costly and more effective compared to usual care in a 2-year and a 5-year time perspective for patients with acute coronary syndrome under the age of 65.
Applying multiple approaches to deepen understanding of mixing and mass transfer in large-scale aerobic fermentations
Authors: Hanspal Navraj , Chai Ning , Allen Billy , Brown Dale 
Published: September 2020

Abstract
Different methods are used at Corteva® Agriscience to improve our understanding of mixing in large-scale mechanically agitated fermentors. These include (a) use of classical empirical correlations, (b) use of small-scale models, and (c) computational fluid dynamics (CFD). Each of these approaches has its own inherent strengths and limitations. Classic empirical or semi-empirical correlations can provide insights into mass transfer, blending, shear, and other important factors but are dependent on the geometry and condition used to develop the correlations. Laboratory-scale modelling can be very useful to study mixing and model the effect of heterogeneity on the culture, but success is highly dependent on the methodology applied. CFD provides an effective means to accelerate the exploration of alternative design strategies through physics-based computer simulations that may not be adequately described by existing knowledge or correlations. However, considerable time and effort is needed to build and validate these models. In this paper, we review the various approaches used at Corteva Agriscience to deepen our understanding of mixing in large-scale fermentation processes.
Remote thermal detection of exfoliation sheet deformation
Authors: Guerin Antoine , Jaboyedoff Michel , Collins Brian D. , Stock Greg M. , Derron Marc-Henri , Abellán Antonio , Matasci Battista 
Published: September 2020

AbstractA growing body of research indicates that rock slope failures, particularly from exfoliating cliffs, are promoted by rock deformations induced by daily temperature cycles. Although previous research has described how these deformations occur, full three-dimensional monitoring of both the deformations and the associated temperature changes has not yet been performed. Here we use integrated terrestrial laser scanning (TLS) and infrared thermography (IRT) techniques to monitor daily deformations of two granitic exfoliating cliffs in Yosemite National Park (CA, USA). At one cliff, we employed TLS and IRT in conjunction with in situ instrumentation to confirm previously documented behavior of an exfoliated rock sheet, which experiences daily closing and opening of the exfoliation fracture during rock cooling and heating, respectively, with a few hours delay from the minimum and maximum temperatures. The most deformed portion of the sheet coincides with the area where both the fracture aperture and the temperature variations are greatest. With the general deformation and temperature relations established, we then employed IRT at a second cliff, where we remotely detected and identified 11 exfoliation sheets that displayed those general thermal relations. TLS measurements then subsequently confirmed the deformation patterns of these sheets showing that sheets with larger apertures are more likely to display larger thermal-related deformations. Our high-frequency monitoring shows how coupled TLS and IRT allows for remote detection of thermally induced deformations and, importantly, how IRT could potentially be used on its own to identify partially detached exfoliation sheets capable of large-scale deformation. These results offer a new and efficient approach for investigating potential rockfall sources on exfoliating cliffs.
Structural characterization of the DRF1 gene of Aegilops speltoides and comparison of its sequence with those of B and other Triticeae genomes
Authors: Thiyagarajan Karthikeyan , Latini Arianna , Cantale Cristina , Galeffi Patrizia 
Published: September 2020

AbstractThe genus Aegilops L. has been intensively investigated due to its close relationship with wheat (Triticum L.) as contributor of B and D subgenomes. Because of their vast genetic diversity, Aegilops species represent a rich source of alleles of agronomic interest, which could be used to widen the wheat gene pool and improve tolerance to diseases, pests, drought, cold and other environmental stresses. We report the isolation and characterization of the Dehydration Responsive Factor 1 (DRF1) gene in three accessions of Ae. speltoides coming from different regions of the Fertile Crescent. The DRF1 gene belongs to the DREB gene family and encodes transcription factors which play a key role in plant response to water stress. As in other cereals, the DRF1 gene in Aegilops speltoides consists of four exons and three introns and undergoes alternative splicing. A processed pseudogene was also identified and compared with the sequence of an actual mRNA transcript, breaking new ground in the understanding of the complex regulation mechanism of this gene. The genetic diversity was evaluated by comparison of inter- and intra-species variation among some Aegilops and Triticeae, by considering both the whole gene and exon 4 sequences. The phylogenetic analyses were able to cluster the sequences in well-supported clades attributable to the genomes analysed. The overall results suggest that there is a high similarity between the B and S genome copies of the DRF1 gene but also features indicating that the two genomes have evolved independently.
Environmental and climatic factors affecting winter hypoxia in a freshwater lake: evidence for a hypoxia refuge and for re-oxygenation prior to spring ice loss
Authors: Davis Michael N. , McMahon Thomas E. , Cutting Kyle A. , Jaeger Matthew E. 
Published: September 2020

AbstractLow dissolved oxygen, or hypoxia, is a common phenomenon in ice-covered lakes in winter. We measured dissolved oxygen (DO) before, during, and after ice-over to characterize the timing, severity, and spatial variability of winter hypoxia in Upper Red Rock Lake, Montana, home to one of the last remaining lacustrine populations of endemic Montana Arctic Grayling (Thymallus arcticus). Unlike most previous investigations of winterkill-prone lakes, we observed considerable horizontal spatial variability in DO, a non-linear winter oxygen depletion rate, and lake-wide re-oxygenation 2–4 weeks prior to spring ice loss. Parts of the upper 1 m of the lake and near stream mouths remained well-oxygenated even during late winter. DO levels were strongly associated with maximum daily air temperature. Our analysis of a 28-year weather record revealed large interannual variability in risk of winter hypoxia, with a slight declining trend in winter severity (number of days with maximum air temperatures ≤ 0°C) in Upper Red Rock Lake. The approach we used in our study provides a useful framework for quantifying and mapping the seasonal dynamics of the extent and severity of winter hypoxia, and for identifying critical winter habitats.
Time-temperature behavior of carbon/epoxy laminates under creep loading
Authors: Ornaghi Heitor L. , Almeida José Humberto S. , Monticeli Francisco M. , Neves Roberta M. , Cioffi Maria Odila H. 
Published: September 2020

AbstractThe time-temperature creep behavior of advanced composite laminates is herein determined through a comprehensive set of experiments and analytical modeling. A complete structure versus property relationship is determined through a wide range of temperature and applied stress levels at the three states of the composite: glassy, glass transition, and rubbery regions. Weibull, Eyring, Burger, and Findley models are employed to predict the experimental data and to better elucidate the material behavior. Experimental creep tests are carried out under ten min and two days aiming at calibrating fitting parameters, which are essential to validate short-term creep tests. The Weibull and Eyring models are more suitable for determining the time-temperature superposition (TTS) creep response in comparison to the Burger and Findley models.
Horsemint as a potential raw material for the food industry: survey on the chemistry of a less studied mint species
Authors: Patonay Katalin , Németh-Zámboriné Éva 
Published: September 2020

AbstractHorsemint (Mentha longifolia L), is wild-growing species, widespread in Eurasia and Africa. The review focuses on its potential utilization as a preservative and flavoring in the food industry based on the polyphenolic and terpenoid composition. Several phenolic antioxidants were detected in horsemint, among which rosmarinic acid may have a key role. Nineteen other acids, and fifty-five flavonoids (six which are de novo) were also identified. The antiradical efficacy in horsemint extract has not yet been adequately justified. Similarly, systematic screening of the flavonoid composition of the species is lacking. Horsemint essential oils possesses an outstandingly wide variability in composition which may serve as basis of special flavoring or antimicrobial agents. The efficacy of horsemint volatiles have been demonstrated against more than twenty microbes. As current literature of horsemint lacks comparable results, the present review provides the broadest and therefore, a critical overview, on its most important secondary compounds and the factors influencing their accumulation.
Opportunistically collected data from aerial surveys reveal spatio-temporal distribution patterns of marine debris in German waters
Authors: Unger Bianca , Herr Helena , Viquerat Sacha , Gilles Anita , Burkhardt-Holm Patricia , Siebert Ursula 
Published: September 2020

AbstractMarine debris is known for its ubiquitousness and harmful effects on marine life. This study is the first analysis to provide information on the distribution of floating marine debris in German waters using aerial survey data collected between 2002 and 2016. During regular harbour porpoise monitoring flights, 191,167 km were covered and 26,512 floating debris items recorded (average encounter rate 0.1387 items/km). Debris was encountered more often in the North Sea than in the Baltic Sea (0.16 items/km; 0.08 items/km). The average encounter rate was higher in offshore waters than in coastal areas. Overlaps of marine debris distribution with ‘Special Areas of Conservation’ are a particular reason for concern. Moreover, the spring months (March–May) were identified to be the time of the year with the highest average encounter rates for marine debris. Fishing-related debris was shown to contribute up to 25% of the total number of all observed items. This study shows that opportunistically collected data on marine debris from aerial surveys are valuable for identifying distribution patterns of floating debris without additional survey effort and costs. These data can be used as baseline information to inform management schemes such as the Marine Strategy Framework Directive.
An investigation into the anthropogenic nexus among consumption of energy, tourism, and economic growth: do economic policy uncertainties matter?
Authors: Adedoyin Festus Fatai , Nathaniel Solomon , Adeleye Ngozi 
Published: September 2020

AbstractGlobal warming has been a pressing issue for the past decade as various economic activities have been flagged and are expected to reduce emissions. While previous studies have examined the energy consumption-emissions-economic growth nexus in significant detail, attention is yet to be given to the role of economic policy uncertainties and human activities such as tourism in a carbon function. Thus, this study aims to investigate the long-run relationship between energy consumption, tourists’ arrivals, economic policy uncertainty, and ecological footprint in the top ten earners from international tourism over the period 1995 to 2015. The fully modified ordinary least square and dynamic ordinary least square estimation techniques and the Dumitrescu and Hurlin causality tests were used in the study. Empirical results suggest that economic policy uncertainties in addition to tourism and energy consumption are drivers of environmental degradation. However, the contribution of energy consumption to ecological footprint is significantly moderated by economic policy uncertainties such that a 1% increase in the latter reduces environmental damage by 0.71%. This study suggests that policy uncertainties matter a great deal for energy and environmental policies. Also, green economic growth is possible if the proper implementation of environmental protection policies can restrict the harmful impact of economic activities on the quality of the environment. Based on the empirical findings, vital energy policy recommendations are suggested.
Is the Social Desirability Effect in Human–Robot Interaction overestimated? A Conceptual Replication Study Indicates Less Robust Effects
Authors: Leichtmann Benedikt , Nitsch Verena 
Published: September 2020

AbstractThe “Computers are social actors” (CASA) assumption (Nass and Moon in J Soc Issues 56:81–103, 2000.https://doi.org/10.1111/0022-4537.00153) states that humans apply social norms and expectations to technical devices. One such norm is to distort one’s own response in a socially desirable direction during interviews. However, findings for such an effect are mixed in the literature. Therefore, a new study on the effect of social desirability bias in human–robot evaluation was conducted, aiming for a conceptual replication of previous findings. In a between-subject laboratory experiment,$$N = 107$$N=107participants had to evaluate the robot and the interaction quality after a short conversation in three different groups: In one group, the evaluation was conducted using (1) the same robot of the former interaction, (2) a different robot, (3) a tablet computer. According to the CASA assumption, it was expected, that evaluations on likability and quality of interaction, are higher in the condition with the same robot conducting the evaluation, compared to a different robot or a tablet computer because robots are treated as social actors and hence humans distort ratings in a socially desirable direction. Based on previous findings, we expected robots to evoke higher anthropomorphism and feelings of social presence compared to the tablet computer as potential explanation. However, the data did not support the hypotheses. Low sample size, low statistical power, lack of measurement validation and other problems that could lead to an overestimation of effect sizes—in this study and the literature in general—are discussed in light of the replicability crisis.