bluuebunny/crossref_metadata_2025_split huggingface dataset:
Behavioral and psychological impact of returning breast density results to Latinas: study protocol for a randomized clinical trial
Authors: Patel Bhavika K. , Ridgeway Jennifer L. , Ghosh Karthik , Rhodes Deborah J. , Borah Bijan , Jenkins Sarah , Suman Vera J. , Norman Aaron , Jewett Matt , Singh Davinder , Vachon Celine M. , Radecki Breitkopf Carmen 
Published: December 2019

Abstract
Background
Breast cancer is the most common cancer and the leading cause of cancer mortality among Latinas. As more is learned about the association between mammographic breast density (MBD) and breast cancer risk, a number of U.S. states adopted legislation and now a federal law mandates written notification of MBD along with mammogram results. These notifications vary in content and readability, though, which may limit their effectiveness and create confusion or concern, especially among women with low health literacy or barriers to screening. The purpose of this study is to determine whether educational enhancement of MBD notification results in increased knowledge, decreased anxiety, and adherence to continued mammography screening among Latina women in a limited-resources setting.

Methods
Latinas LEarning About Density (LLEAD) is a randomized clinical trial (RCT) comparing the impact of three notification approaches on behavioral and psychological outcomes in Latina women. Approximately 2000 Latinas undergoing screening mammography in a safety-net community clinic will be randomized 1:1:1 to mailed notification (usual care); mailed notification plus written educational materials (enhanced); or mailed notification, written educational materials, plus verbal explanation by a promotora (interpersonal). The educational materials and verbal explanations are available in Spanish or English. Mechanisms through which written or verbal information influences future screening motivation and behavior will be examined, as well as moderating factors such as depression and worry about breast cancer, which have been linked to diagnostic delays among Latinas. The study includes multiple psychological measures (anxiety, depression, knowledge about MBD, perceived risk of breast cancer, worry, self-efficacy) and behavioral outcomes (continued adherence to mammography). Measurement time points include enrollment, 2–4 weeks post-randomization, and 1 and 2 years post-randomization. Qualitative inquiry related to process and outcomes of the interpersonal arm and cost analysis related to its implementation will be undertaken to understand the intervention’s delivery and transferability.

Discussion
Legislation mandating written MBD notification may have unintended consequences on behavioral and psychological outcomes, particularly among Latinas with limited health literacy and resources. This study has implications for cancer risk communication and will offer evidence on the potential of generalizable educational strategies for delivering information on breast density to Latinas in limited-resource settings.

Trial registration
ClinicalTrials.gov, NCT02910986. Registered on 21 September 2016.
Items from the WHO Trial Registration Data Set can be found in this protocol.
Proteomic analysis of the second-generation merozoites of Eimeria tenella under nitromezuril and ethanamizuril stress
Authors: Li Xue-Yan , Liu Li-Li , Zhang Min , Zhang Li-Fang , Wang Xiao-Yang , Wang Mi , Zhang Ke-Yu , Liu Ying-Chun , Wang Chun-Mei , Xue Fei-Qun , Fei Chen-Zhong 
Published: December 2019

Abstract
Background
Eimeria tenella is a highly pathogenic coccidian that causes avian coccidiosis. Both nitromezuril (NZL) and ethanamizuril (EZL) are novel triazine compounds with high anticoccidial activity, but the mechanisms of their action are still unclear. This study explored the response of E. tenella to NZL and EZL by the study of changes in protein composition of the second-generation merozoites.

Methods
Label-free quantification (LFQ) proteomics of the second-generation merozoites of E. tenella following NZL and EZL treatment were studied by LC-MS/MS to explore the mechanisms of action. The identified proteins were annotated and analyzed by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and protein-protein interaction (PPI) networks analysis.

Results
A total of 1430 proteins were identified by LC-MS/MS, of which 375 were considered as differential proteins in response to drug treatment (DPs). There were 26 only found in the NZL treatment group (N-group), 63 exclusive to the EZL treatment group (E-group), and 80 proteins were present in both drug groups. In addition, among the DPs, the abundant proteins with significantly altered expression in response to drug treatment (SDPs) were found compared with the C-group, of which 49 were upregulated and 51 were downregulated in the N-group, and 66 upregulated and 79 downregulated in the E-group. Many upregulated proteins after drug treatment were involved in transcription and protein metabolism, and surface antigen proteins (SAGs) were among the largest proportion of the downregulated SDPs. Results showed the top two enriched GO terms and the top one enriched pathway treated with EZL and NZL were related, which indicated that these two compounds had similar modes of action.

Conclusions
LFQ proteomic analysis is a feasible method for screening drug-related proteins. Drug treatment affected transcription and protein metabolism, and SAGs were also affected significantly. This study provided new insights into the effects of triazine anticoccidials against E. tenella.
The immune system in sporadic inclusion body myositis patients is not compromised by blood-flow restricted exercise training
Authors: Jensen Kasper Yde , Jacobsen Mikkel , Schrøder Henrik Daa , Aagaard Per , Nielsen Jakob Lindberg , Jørgensen Anders Nørkær , Boyle Eleanor , Bech Rune Dueholm , Rosmark Sofie , Diederichsen Louise Pyndt , Frandsen Ulrik 
Published: December 2019

Abstract
Background
Sporadic inclusion body myositis (sIBM) is clinically characterised by progressive proximal and distal muscle weakness and impaired physical function while skeletal muscle tissue displays abnormal cellular infiltration of T cells, macrophages, and dendritic cells. Only limited knowledge exists about the effects of low-load blood flow restriction exercise in sIBM patients, and its effect on the immunological responses at the myocellular level remains unknown. The present study is the first to investigate the longitudinal effects of low-load blood flow restriction exercise on innate and adaptive immune markers in skeletal muscle from sIBM patients.

Methods
Twenty-two biopsy-validated sIBM patients were randomised into either 12 weeks of low-load blood flow restriction exercise (BFRE) or no exercise (CON). Five patients from the control group completed 12 weeks of BFRE immediately following participation in the 12-week control period leading to an intervention group of 16 patients. Muscle biopsies were obtained from either the m. tibialis anterior or the m. vastus lateralis for evaluation of CD3-, CD8-, CD68-, CD206-, CD244- and FOXP3-positive cells by three-colour immunofluorescence microscopy and Visiopharm-based image analysis quantification. A linear mixed model was used for the statistical analysis.

Results
Myocellular infiltration of CD3−/CD8+ expressing natural killer cells increased following BFRE (P < 0.05) with no changes in CON. No changes were observed for CD3+/CD8− or CD3+/CD8+ T cells in BFRE or CON. CD3+/CD244+ T cells decreased in CON, while no changes were observed in BFRE. Pronounced infiltration of M1 pro-inflammatory (CD68+/CD206−) and M2 anti-inflammatory (CD68+/CD206+) macrophages were observed at baseline; however, no longitudinal changes in macrophage content were observed for both groups.

Conclusions
Low-load blood flow restriction exercise elicited an upregulation in CD3−/CD8+ expressing natural killer cell content, which suggests that 12 weeks of BFRE training evokes an amplified immune response in sIBM muscle. However, the observation of no changes in macrophage or T cell infiltration in the BFRE-trained patients indicates that patients with sIBM may engage in this type of exercise with no risk of intensified inflammatory activity.
Robustness of zero-augmented models over generalized linear models in analysing fertility data in Nigeria
Authors: Kareem Yusuf Olushola , Morhason-Bello Imran O. , Adebowale Ayo Stephen , Akinyemi Joshua Odunayo , Yusuf Oyindamola Bidemi 
Published: December 2019

Abstract
Objective
Fertility is a count data usually rightly skewed and exhibiting large number of zeros than the distributional assumption of the generalized linear models (GLMs). This study examined the robustness of zero-augmented models over GLMs to fit fertility data across regions in Nigeria. The 2013 Nigeria Demographic and Health Survey data were used. The fertility models fitted included: Poisson, negative binomial, zero-inflated Poisson, zero-inflated negative binomial, hurdle Poisson and hurdle negative binomial. Akaike Information Criteria (AIC) and Bayesian Information Criteria (BIC) were used to identify the model with best fit (α = 0.05).

Results
The percentage of zero count in the fertility responses were 21.3, 23.9, 31.1, 30.7, 37.6 and 42.4 in North West, North East, North Central, South West, South South and South East regions respectively. In all the six regions in Nigeria, the zero-augmented models were better than the generalized linear models except for North Central. Extensively, the zero-augmented negative binomial based models were of better fit than their Poisson based counterparts; or in rare cases maybe indistinguishable. However, specific family of zero-augmented model is recommended for each region in Nigeria.
Co-exposure to lipopolysaccharide and desert dust causes exacerbation of ovalbumin-induced allergic lung inflammation in mice via TLR4/MyD88-dependent and -independent pathways
Authors: Ren Yahao , Ichinose Takamichi , He Miao , Youshida Seiichi , Nishikawa Masataka , Sun Guifan 
Published: December 2019

Abstract
Background
Lipopolysaccharide (LPS) often presents in high concentrations in particulate matter (PM), few studies have reported the enhancing effects of both LPS and PM on airway inflammation in mice and the role of toll-like receptors (TLRs) in this process. Asian sand dust (ASD) is observed most frequently during the spring. This study aimed to clarify the role of TLRs in murine lung eosinophilia exacerbated by ASD and LPS.

Methods
The effects of LPS and ASD co-treatment on ovalbumin (OVA)-induced lung eosinophilia were investigated using wild-type (WT), TLR2−/−, TLR4−/−, and adaptor protein myeloid differentiation factor 88 (MyD88)−/− BALB/c mice. ASD was heated (H-ASD) to remove the toxic organic substances. WT, TLR2−/−, TLR4−/− and MyD88−/− BALB/c mice were intratracheally instilled with four different combinations of LPS, H-ASD and OVA treatment. Subsequently, the pathological changes in lungs, immune cell profiles in bronchoalveolar lavage fluid (BALF), inflammatory cytokines/chemokines levels in BALF and OVA-specific immunoglobulin (Ig) in serum were analyzed.

Results
In WT mice, H-ASD + LPS exacerbated OVA-induced lung eosinophilia. This combination of treatments increased the proportion of eosinophils and the levels of IL-5, IL-13, eotaxin in BALF, as well as the production of OVA-specific IgE and IgG1 in serum compared to OVA treatment alone. Although these effects were stronger in TLR2−/− mice than in TLR4−/− mice, the expression levels of IL-5, IL-13, eotaxin were somewhat increased in TLR4−/− mice treated with OVA + H-ASD + LPS. In MyD88−/− mice, this pro-inflammatory mediator-induced airway inflammation was considerably weak and the pathological changes in lungs were negligible.

Conclusions
These results suggest that LPS and H-ASD activate OVA-induced Th2 response in mice, and exacerbate lung eosinophilia via TLR4/MyD88, TLR4/TRIF and other TLR4-independent pathways.
Development of the Stanford Social Dimensions Scale: initial validation in autism spectrum disorder and in neurotypicals
Authors: Phillips Jennifer M. , Uljarević Mirko , Schuck Rachel K. , Schapp Salena , Solomon Elizabeth M. , Salzman Emma , Allerhand Lauren , Libove Robin A. , Frazier Thomas W. , Hardan Antonio Y. 
Published: December 2019

AbstractBackgroundThe aim of this paper was to provide an initial validation of a newly developed parent questionnaire—the Stanford Social Dimensions Scale (SSDS), designed to capture individual differences across several key social dimensions including social motivation in children and adolescents with and without psychiatric disorders.MethodsThe initial validation sample was comprised of parents of 175 individuals with autism spectrum disorder (ASD) (35 females, 140 males;Mage= 7.19 years,SDage= 3.96) and the replication sample consisted of 624 parents of children who were either typically developing or presented with a range of neurodevelopmental and neuropsychiatric disorders (302 females, 322 males;Mage= 11.49 years, SDage= 4.48). Parents from both samples completed the SSDS and the Social Responsiveness Scale (SRS-2).ResultsExploratory Structural Equation Modeling indicated that a 5-factor model provided adequate to excellent fit to the data in the initial ASD sample (comparative fit index [CFI] = .940, Tucker-Lewis Index [TLI] = .919, root mean square error of approximation [RMSEA] = .048, standardized root mean square residual [SRMR] = .038). The identified factors were interpreted as Social Motivation, Social Affiliation, Expressive Social Communication, Social Recognition, and Unusual Approach. This factor structure was further confirmed in Sample 2 (CFI = 946, TLI = .930, RMSEA = .044, SRMR = .026). Internal consistency for all subscales was in the good to excellent range across both samples as indicated by Composite Reliability scores of ≥ .72. Convergent and divergent validity was strong as indexed by the pattern of correlations with relevant SRS-2 and Child Behavior Checklist domains and with verbal and non-verbal intellectual functioning scores in Sample 1 and with the Need to Belong Scale and Child Social Preference Scale scores in Sample 2. Across both samples, females had higher social motivation and expressive social communication scores. Discriminant validity was strong given that across all SSDS subscales, the ASD sample had significantly higher impairment than both the typically developing group and the group with other clinical conditions, which in turn, had significantly higher impairment than the typically developing group.ConclusionsOur findings provide initial validation of a new scale designed to comprehensively capture individual differences in social motivation and other key social dimensions in ASD.
Assessment of hepatocellular carcinoma treatment response with LI-RADS: a pictorial review
Authors: Voizard Nicolas , Cerny Milena , Assad Anis , Billiard Jean-Sébastien , Olivié Damien , Perreault Pierre , Kielar Ania , Do Richard K. G. , Yokoo Takeshi , Sirlin Claude B. , Tang An 
Published: December 2019

AbstractComputed tomography (CT) and magnetic resonance imaging (MRI) play critical roles for assessing treatment response of hepatocellular carcinoma (HCC) after locoregional therapy. Interpretation is challenging because posttreatment imaging findings depend on the type of treatment, magnitude of treatment response, time interval after treatment, and other factors. To help radiologists interpret and report treatment response in a clear, simple, and standardized manner, the Liver Imaging Reporting and Data System (LI-RADS) has developed a Treatment Response (LR-TR) algorithm. Introduced in 2017, the system provides criteria to categorize response of HCC to locoregional treatment (e.g., chemical ablation, energy-based ablation, transcatheter therapy, and radiation therapy). LR-TR categories include Nonevaluable, Nonviable, Equivocal, and Viable. LR-TR does not apply to patients on systemic therapies. This article reviews the LR-TR algorithm; discusses locoregional therapies for HCC, treatment concepts, and expected posttreatment findings; and illustrates LI-RADS treatment response assessment with CT and MRI.
Microvesicles isolated from 5-azacytidine-and-resveratrol-treated mesenchymal stem cells for the treatment of suspensory ligament injury in horse—a case report
Authors: Kornicka-Garbowska Katarzyna , Pędziwiatr Rafał , Woźniak Paulina , Kucharczyk Katarzyna , Marycz Krzysztof 
Published: December 2019

Abstract
Background
In athlete horses, suspensory ligament (SL) injuries are the most common cause of lameness. Healing of SL injury is still problematic, and even proper rehabilitation and pharmacological therapy do not guarantee returning to the initial performance level. In our previous studies, we have shown that a combination of 5-azacytidine (AZA) and resveratrol (RES) exerts beneficial, rejuvenating effects on metabolic syndrome derived adipose-derived stem cells (ASCs). Thus, in the presented research, we investigate whether not only rejuvenated ASC but also microvesicles (MVsAZA/RES) secreted by them possess enhanced regenerative properties in SL injury.

Methods
In the presented study, a 6-year-old Dutch Warmblood gelding, working in jumping, was diagnosed with SL injury using ultrasonography, Doppler, real-time elastography and thermography. As a therapeutic strategy, the affected animal was treated with extracellular microvesicles derived from ASC treated with the combination of 5-azacytydine (AZA) and resveratrol (RES) (MVsAZA/RES).

Results
First, anti-apoptotic effects of MVsAZA/RES were tested in co-culture with metabolic syndrome derived ASC. The proliferation of cells and expression of pro-apoptotic genes were investigated. Then, MVsAZA/RES were injected directly into the injured SL of the Dutch Warmblood gelding. In vitro assays revealed that MVsAZA/RES enhance the proliferation of ASC and exert an anti-apoptotic effect. In the affected horse, the application of MVsAZA/RES resulted in increased lesion filling and improvement of angiogenesis and elasticity in injured tissue.

Conclusions
As MVsAZA/RES mimic several of the biological actions exerted by ASC, they have become an alternative for stem cell-based therapies and can be effectively applied for the treatment of SL injury in horses.
Multi-security-level cloud storage system based on improved proxy re-encryption
Authors: Shen Jinan , Deng Xuejian , Xu Zhenwu 
Published: December 2019

AbstractBased on the characteristics and data security requirements of the cloud environment, we present a scheme for a multi-security-level cloud storage system that is combined with AES symmetric encryption and an improved identity-based proxy re-encryption (PRE) algorithm. Our optimization includes support for fine-grained control and performance optimization. Through a combination of attribute-based encryption methods, we add a fine-grained control factor to our algorithm in which each authorization operation is only valid for a single factor. By reducing the number of bilinear mappings, which are the most time-consuming processes, we achieve our aim of optimizing performance. Last but not least, we implement secure data sharing among heterogeneous cloud systems. As shown in experiment, our proposed multi-security-level cloud storage system implements services such as the direct storage of data, transparent AES encryption, PRE protection that supports fine-grained and ciphertext heterogeneous transformation, and other functions such as authentication and data management. In terms of performance, we achieve time-cost reductions of 29.8% for the entire process, 48.3% for delegation and 47.2% for decryption.
The scale of neurodegeneration in moderate-to-severe traumatic brain injury: a systematic review protocol
Authors: Sharma Bhanu , Changoor Alana T. , Monteiro Leanne , Colella Brenda , Green Robin E. A. 
Published: December 2019

Abstract
Background
Our understanding of recovery after moderate-to-severe traumatic brain injury (TBI) has shifted. Until recently, it was presumed that following a period of acute neurological vulnerability, the brain remained stable in the chronic stages of injury. However, recent research has shown neurodegeneration in the chronic stages of moderate-to-severe TBI, challenging the assumption of neurological stability. While there is extensive evidence that neurodegeneration occurs, debate remains regarding the scale and timing. This systematic review will evaluate the scale and timelines of neurodegeneration in adult patients with moderate-to-severe TBI.

Methods
Literature searches will be conducted in six electronic databases (from inception onwards), including MEDLINE, EMBASE, PsycINFO, CINAHL, SportDiscus, and Cochrane Central Register of Controlled Trials. We will include observational studies that examine neurodegenerative changes within a single sample of TBI patients or studies that compare neuroimaging outcomes between TBI patients and healthy controls. Our primary outcome is structural neuroimaging, and our secondary outcome is diffusion tensor imaging for detection of post-injury white matter changes. All screening, data extraction, and study quality appraisal will be performed independently by the same two study members. It is expected that a narrative summary of the literature will be produced. If feasible, we will conduct a random-effects meta-analysis. However, given the expected heterogeneity between studies (with respect to, for example, timing of imaging, regions imaged) we do not expect to perform a meta-analysis; rather, a narrative synthesis of our findings is expected to be performed.

Discussion
Understanding the scale and timelines of neurodegeneration in moderate-to-severe TBI (as well as which brain areas are most vulnerable to chronic declines) can inform intervention research designed to offset such changes. This may help improve patient outcome following moderate-to-severe TBI and, in turn, reduce the burden of the injury.

Systematic review registration
PROSPERO CRD42019117548
Periodic averaging method for impulsive stochastic dynamical systems driven by fractional Brownian motion under non-Lipschitz condition
Authors: Khalaf Anas Dheyab , Abouagwa Mahmoud , Wang Xiangjun 
Published: December 2019

AbstractThis paper presents the periodic averaging principle for impulsive stochastic dynamical systems driven by fractional Brownian motion (fBm). Under non-Lipschitz condition, we prove that the solutions to impulsive stochastic differential equations (ISDEs) with fBm can be approximated by the solutions to averaged SDEs without impulses both in the sense of mean square and probability. Finally, an example is provided to illustrate the theoretical results.