bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychosocial Screening in Sickle Cell Disease: Validation of the Psychosocial Assessment Tool
Authors: Reader Steven K , Keeler Colleen N , Chen Fang Fang , Ruppe Nicole M , Rash-Ellis Diana L , Wadman Jean R , Miller Robin E , Kazak Anne E 
Published: February 2020

AbstractObjectiveFamilies of youth with Sickle Cell Disease (SCD) can face psychosocial adversity including emotional distress, functional impairments, and sociodemographic risk factors. Systematic screening of psychosocial risk can identify families who may benefit from further assessment and evidence-based care. The Psychosocial Assessment Tool (PAT) is a brief caregiver-report screener based on the tri-level Pediatric Psychosocial Preventative Health Model (PPPHM).MethodsFindings are presented from the baseline assessment of a longitudinal study validating a Sickle Cell version of the PAT 2.0. Primary caregivers of 136 youth with SCD receiving care through a multidisciplinary SCD clinic in a children’s hospital completed the PAT and validation measures. A subset of 25 caregivers completed the PAT a second time within 3–5 weeks.ResultsInternal consistency for the total score was strong (α = .87), and for the subscales was moderate to strong (α  =  .74–.94), with the exception of the Family Structure (α  =  .38), Caregiver Beliefs (α  =  .48), and Stress Reactions (α  =  .56) subscales. Test–retest reliability was also strong (r = .86, p &lt; .001). Moderate to strong correlations with all except two criteria measures provided validation for the total and subscale scores. Validation measures varied significantly across the three levels of the PPPHM.ConclusionsResults provide support for the reliability and validity of the PAT in SCD. Systematic screening with the PAT can help identify families of youth with SCD at risk for psychosocial problems and potentially help connect them to appropriate services.
Mid-IR spectra of the M-type Mira variable R Tri observed with theSpitzerIRS
Authors: Baylis-Aguirre Dana K , Creech-Eakman M J , Güth Tina 
Published: February 2020

ABSTRACTWe present analysis of mid-infrared (IR) spectra of the oxygen-rich Mira variable R Tri. The data were taken with the Spitzer Infrared Spectrometer (IRS) as part of a study tracking how Mira variables’ regular pulsations affect circumstellar envelopes. We detected strong emission lines at 13.87, 16.18, and 17.6 $\hbox{$\mu $m}$, and one strong absorption feature at 14.98 $\hbox{$\mu $m}$. The emission features at 13.87 and 16.18 $\hbox{$\mu $m}$ are excited vibrational bands of CO2, while the absorption feature is the fundamental ν2 band. The 17.6 $\hbox{$\mu $m}$ emission feature has a completely different character than the molecular lines and we report its identification as Fe i fluorescence. We used a two-slab model with the radiative transfer code radex to model the CO2 Q-branch bandheads. Our results indicate a slab of gas with T∼600 K located at ∼3–4 R*. The cool temperature discrepancy with the radius provides observational evidence for the previously theoretical ‘refrigeration zone’.
On the vortex evolution in non-isothermal protoplanetary discs
Authors: Tarczay-Nehéz D , Regály Zs , Vorobyov E 
Published: February 2020

ABSTRACT
It is believed that large-scale horseshoe-like brightness asymmetries found in dozens of transitional protoplanetary discs are caused by anticyclonic vortices. These vortices can play a key role in planet formation, as mm-sized dust – the building blocks of planets – can be accumulated inside them. Anticyclonic vortices are formed by the Rossby wave instability, which can be excited at the gap edges opened by a giant planet or at sharp viscosity transitions of accretionally inactive regions. It is known that vortices are prone to stretching and subsequent dissolution due to disc self-gravity for canonical disc masses in the isothermal approximation. To improve the hydrodynamic model of protoplanetary discs, we include the disc thermodynamics in our model. In this paper, we present our results on the evolution of the vortices formed at the outer edge of an accretionally inactive region (dead zone) assuming an ideal equation of state and taking PdV work, disc cooling in the β-approximation, and disc self-gravity into account. Thermodynamics affects the offset and the mode number (referring to the number of small vortices at the early phase) of the RWI excitation, as well as the strength, shape, and lifetime of the large-scale vortex formed through merging of the initial small vortices. We found that the inclusion of gas thermodynamics results in stronger, however decreased lifetime vortices. Our results suggest that a hypothetical vortex-aided planet formation scenario favours effectively cooling discs.
Disrupted Gene Networks in Subfertile Hybrid House Mice
Authors: Morgan Katy , Harr Bettina , White Michael A , Payseur Bret A , Turner Leslie M 
Published: February 2020

AbstractThe Dobzhansky–Muller (DM) model provides a widely accepted mechanism for the evolution of reproductive isolation: incompatible substitutions disrupt interactions between genes. To date, few candidate incompatibility genes have been identified, leaving the genes driving speciation mostly uncharacterized. The importance of interactions in the DM model suggests that gene coexpression networks provide a powerful framework to understand disrupted pathways associated with postzygotic isolation. Here, we perform weighted gene coexpression network analysis to infer gene interactions in hybrids of two recently diverged European house mouse subspecies, Mus mus domesticus and M. m. musculus, which commonly show hybrid male sterility or subfertility. We use genome-wide testis expression data from 467 hybrid mice from two mapping populations: F2s from a laboratory cross between wild-derived pure subspecies strains and offspring of natural hybrids captured in the Central Europe hybrid zone. This large data set enabled us to build a robust consensus network using hybrid males with fertile phenotypes. We identify several expression modules, or groups of coexpressed genes, that are disrupted in subfertile hybrids, including modules functionally enriched for spermatogenesis, cilium and sperm flagellum organization, chromosome organization, and DNA repair, and including genes expressed in spermatogonia, spermatocytes, and spermatids. Our network-based approach enabled us to hone in on specific hub genes likely to be influencing module-wide gene expression and hence potentially driving large-effect DM incompatibilities. A disproportionate number of hub genes lie within sterility loci identified previously in the hybrid zone mapping population and represent promising candidate barrier genes and targets for future functional analysis.
Gatekeepers of the Profession: Using the Code of Ethics to Guide Supervision
Authors: Hicks Jennifer 
Published: February 2020

Abstract
Clinical practicum and internship supervisors often share the role of gatekeepers with university faculty to ensure that students meet all necessary and applicable professional competencies before moving on to the next step in their music therapy journey (Dileo, 2001; Hsiao, 2014). However, the interpretation of these competencies can be subjective, and predicting student success can be challenging (Dileo, 2000). Therefore, making the decision of whether to pass a student from a clinical practicum or internship can be complex and filled with ethical implications for all involved. This paper explores that decision through the lenses of both the past and current American Music Therapy Association (AMTA) Codes of Ethics using Dileo’s (2000) Ethical Decision-Making Model. An ethical dilemma, based upon the author’s supervisory experiences, is presented here and analyzed using the following guidelines: setting and context; problems and issues; personal responses, beliefs, and values; obligations; Codes of Ethics standards and principles; laws and institutional and professional policies; opportunities for consultation; possible solutions and consequences; and implementation.
The promise of toxicogenomics for genetic toxicology: past, present and future
Authors: David Rhiannon 
Published: February 2020

Abstract
Toxicogenomics, the application of genomics to toxicology, was described as ‘a new era’ for toxicology. Standard toxicity tests typically involve a number of short-term bioassays that are costly, time consuming, require large numbers of animals and generally focus on a single end point. Toxicogenomics was heralded as a way to improve the efficiency of toxicity testing by assessing gene regulation across the genome, allowing rapid classification of compounds based on characteristic expression profiles. Gene expression microarrays could measure and characterise genome-wide gene expression changes in a single study and while transcriptomic profiles that can discriminate between genotoxic and non-genotoxic carcinogens have been identified, challenges with the approach limited its application. As such, toxicogenomics did not transform the field of genetic toxicology in the way it was predicted. More recently, next generation sequencing (NGS) technologies have revolutionised genomics owing to the fact that hundreds of billions of base pairs can be sequenced simultaneously cheaper and quicker than traditional Sanger methods. In relation to genetic toxicology, and thousands of cancer genomes have been sequenced with single-base substitution mutational signatures identified, and mutation signatures have been identified following treatment of cells with known or suspected environmental carcinogens. RNAseq has been applied to detect transcriptional changes following treatment with genotoxins; modified RNAseq protocols have been developed to identify adducts in the genome and Duplex sequencing is an example of a technique that has recently been developed to accurately detect mutation. Machine learning, including MutationSeq and SomaticSeq, has also been applied to somatic mutation detection and improvements in automation and/or the application of machine learning algorithms may allow high-throughput mutation sequencing in the future. This review will discuss the initial promise of transcriptomics for genetic toxicology, and how the development of NGS technologies and new machine learning algorithms may finally realise that promise.
L’alimentation en milieu scolaire : appuyer l’offre d’aliments et de boissons sains
Authors: Critch Jeffrey N 
Published: February 2020

Résumé
L’adoption de politiques et de directives alimentaires dans les écoles canadiennes permet d’accroître l’offre et la consommation d’aliments riches en nutriments tout en réduisant l’accès à des aliments et des boissons riches en sucres, en sodium et en gras saturés. Ces politiques favorisent des changements positifs pour la santé des enfants et des adolescents, tels qu’un meilleur indice de masse corporelle. Cependant, elles ont des effets mitigés sur la performance scolaire. Le présent document de principes présente les principaux éléments des politiques alimentaires en milieu scolaire, notamment les normes nutritionnelles. Ces politiques doivent respecter les recommandations du Guide alimentaire canadien et promouvoir la consommation d’aliments et de boissons riches en nutriments, dont la teneur en gras saturé, en sucre et en sodium est plus faible.
School nutrition: Support for providing healthy food and beverage choices in schools
Authors: Critch Jeffrey N 
Published: February 2020

Abstract
The implementation of nutrition policies and guidelines in Canadian schools has increased the availability and consumption of nutrient-rich foods while reducing access to and consumption of foods and beverages that are high in sugars, sodium, and saturated fats. Positive changes in health outcomes for children and youth, such as improved body mass indices, have been observed. However, observed impacts of school nutrition policies on academic performance have been mixed. This statement reviews key elements of school nutrition policies, with specific focus on nutrition standards. School nutrition policies should align with recommendations in Canada’s Food Guide and promote nutrient-rich foods and beverages that are lower in saturated fat, sugar, and sodium.
Petrographic, Geochemical and Isotopic (Sr–Nd–Pb–Os) Study of Plio-Quaternary Volcanics and the Tertiary Basement in the Jorullo-Tacámbaro Area, Michoacán-Guanajuato Volcanic Field, Mexico
Authors: Guilbaud Marie-Noëlle , Siebe Claus , Rasoazanamparany Christine , Widom Elisabeth , Salinas Sergio , Castro Govea Renato 
Published: February 2020

AbstractThe origin of the large diversity of rock types erupted along the subduction-related Trans-Mexican Volcanic Belt (TMVB) remains highly debated. In particular, several hypotheses have been proposed to explain the contemporary eruption of calc-alkaline and alkaline magmas along the belt. The Michoacán-Guanajuato Volcanic Field (MGVF) is an atypical, vast region of monogenetic activity located in the western-central part of the TMVB. Here we present new petrographic, geochemical, and isotopic (Sr–Nd–Pb–Os) data on recent volcanics in the Jorullo-Tacámbaro area that is the closest to the oceanic trench. TMVB-related volcanics in this area are Plio-Quaternary (&lt;5 Ma) and mainly form a calc-alkaline series from basalts to dacites, with rare (&lt;5 vol. %) alkaline rocks that range from trachybasalts to trachydacites, and transitional samples. Crystal textures are consistent with rapid crystallization at shallow depth and processes of mixing of similar magma batches (magma recharge). All of the samples exhibit an arc-type trace element pattern. Alkaline and transitional magmas have higher Na2O and K2O, lower Al2O3, and higher concentrations in incompatible elements (e.g. Sr, K, Ba, Th, Ce, P) compared to calc-alkaline rocks. Calc-alkaline rocks are similar isotopically to transitional and alkaline samples, except for a few low 87Sr/86Sr samples. Sr, Nd and Pb isotopes do not correlate with MgO or 187Os/188Os, indicating that they were not significantly influenced by crustal contamination. Isotopic and trace-element systematics suggest that the Tacámbaro magmas are produced by melting of a mantle wedge fluxed by fluids derived from a mixture of subducted sediments and altered oceanic crust. Alkaline and transitional magmas can be derived from a lower degree of partial melting of a similar source to that of the calc-alkaline rocks, whereas the few low 87Sr/86Sr calc-alkaline rocks require a lower proportion of fluid derived from oceanic sediments and crust. Volcanism at the trenchward edge of the MGVF was thus driven purely by subduction during the last 5 Ma, hence discarding slab rollback in this sector of the TMVB.
Most Granitoid Rocks are Cumulates: Deductions from Hornblende Compositions and Zircon Saturation
Authors: Barnes Calvin G , Werts Kevin , Memeti Vali , Ardill Katie 
Published: February 2020

Abstract
Cumulate processes in granitic magma systems are thought by some to be negligible and by others to be common and widespread. Because most granitic rocks lack obvious evidence of accumulation, such as modal layering, other means of identifying cumulate rocks and estimating proportions of melt lost must be developed. The approach presented here utilizes major and trace element compositions of hornblende to estimate melt compositions necessary for zircon saturation. It then compares these estimates with bulk-rock compositions to estimate proportions of extracted melt. Data from three arc-related magmatic systems were used (English Peak pluton, Wooley Creek batholith, and Tuolumne Intrusive Complex). In all three systems, magmatic hornblende displays core-to-rim decreases in Zr, Hf, and Zr/Hf. This zoning indicates that zircon must have fractionated during crystallization of hornblende, at temperatures greater than 800 °C. This T estimate is in agreement with Ti-in-zircon thermometry, which yields a maximum T estimate of 855 °C. On the basis of this evidence, concentrations of Zr in melts from which hornblende and zircon crystallized were calculated by (1) applying saturation equations to bulk-rock compositions, (2) applying saturation equations to calculated melt compositions, and (3) using hornblende/melt partition coefficients for Zr. The results indicate that melt was lost during crystallization of the granitic magmas, conservatively at least as much as 40 %. These results are in agreement with published estimates of melt loss from other plutonic systems and suggest that bulk-rock compositions of many granitic rocks reflect crystal accumulation and are therefore inappropriate for use in thermodynamic calculations and in direct comparison of potentially consanguineous volcanic and plutonic suites.
Reducing the Toxicity of Radiotherapy for Pancreatic Cancer With Magnetic Resonance-guided Radiotherapy
Authors: Tchelebi Leila T , Zaorsky Nicholas G , Rosenberg Jennifer C , Sharma Navesh K , Tuanquin Leonard C , Mackley Heath B , Ellis Rodney J 
Published: February 2020

AbstractPancreatic cancer is a highly fatal malignancy for which surgery is currently considered to be the only curative treatment. However, less than a quarter of patients have disease amenable to definitive surgical resection. Local treatment with radiation therapy is a promising alternative to surgery for those patients with unresectable disease. However, conventional radiation techniques with computed tomography (CT)-guided therapy have yielded disappointing results due to the inability to deliver ablative doses of ionizing radiation, while sparing the radiosensitive adjacent organs at risk. Magnetic resonance-guided radiotherapy (MRgRT) has emerged as an alternative to CT-guided radiation treatment which allows for the delivery of higher doses of radiation with low toxicity to surrounding structures. Further study into the use of MRgRT and dose escalation for locally advanced unresectable pancreatic cancer is needed.
Reenvisioning Advising Models: Meeting the Needs of Prelicensure Nursing Students
Authors: Morton Jennifer L. , Kramlich Debra , Simpson Nancy 
Published: February 2020

Abstract
Effective academic advising is a dynamic process that is linked to student success. In 2015, a private institution in northern New England began the process of reenvisioning academic advisement as a quality improvement goal for program evaluation. A three-tiered model was used that encompassed targeted academic advising during the early foundational period (core coursework), academic advising during intensive theory and clinical coursework, and postgraduation advising targeting NCLEX-RN® support and mentoring. The goal of this advising model is to develop a relationship with students in forming a plan that leads to a self-fulfilling academic journey and life.
Personalized medicine for asthma in tropical regions
Authors: Caraballo Luis , Acevedo Nathalie , Zakzuk Josefina 
Published: February 2020

Purpose of review
Precision medicine could help to improve diagnosis and treatment of asthma; however, in the tropics there are special conditions to be considered for applying this strategy. In this review, we analyze recent advances of precision allergology in tropical regions, highlighting its limitations and needs in high-admixed populations living under environments with high exposure to house dust mites and helminth infections.

Recent findings
Advances have been made regarding the genetic characterization of the great diversity of populations living in the tropics. Genes involved in shared biological pathways between immune responses to nematodes and the allergic responses suggested new mechanisms of predisposition. Genome wide association studies of asthma are progressively focusing on some highly replicated genes such as those in chromosome 17q31-13, which have been also replicated in African ancestry populations. Some diagnostic difficulties, because of the endemicity of helminth infections, are now more evident in the context of phenotype definition.

Summary
The clinical impact of the advances in precision medicine for asthma in the tropics is still limited and mainly related to component resolved diagnosis. More basic and clinical research is needed to identify genetic, epigenetic, or other biologic markers that allow and accurate definition of phenotypes and endotypes of this heterogeneous disease. This will substantially improve the selection of personalized treatments.
Rapid Transition From Methadone to Buprenorphine Utilizing a Micro-dosing Protocol in the Outpatient Veteran Affairs Setting
Authors: De Aquino Joao P. , Fairgrieve Christopher , Klaire Sukhpreet , Garcia-Vassallo Gabriela 
Published: February 2020

Objectives:
Alternative transition protocols from methadone to buprenorphine in the treatment of opioid use disorder (OUD) are needed to reduce the risk of precipitated withdrawal and opioid use during induction.

Methods:
Case report (n = 1).

Results:
One patient with OUD underwent a rapid microinduction outpatient protocol that did not cause precipitated withdrawal or require preceding taper before cessation of methadone. The induction was carried out safely in the outpatient setting.

Conclusions:
This report provides a patient-centered approach demonstrating feasibility and cost-effectiveness of rapid transition to buprenorphine in the US outpatient psychiatry setting. Barriers to adherence to opioid agonist therapy may be reduced using this protocol.
Daily Cannabis Use During Pregnancy and Postpartum in a State With Legalized Recreational Cannabis
Authors: Barbosa-Leiker Celestina , Burduli Ekaterina , Smith Crystal Lederhos , Brooks Olivia , Orr Michael , Gartstein Maria 
Published: February 2020

Objective:
To identify perceptions of risks and benefits of cannabis use during pregnancy and postpartum from the patient perspective.

Methods:
Pregnant and postpartum (up to 3 months) women residing in a state that legalized the sale of recreational cannabis in 2012 were interviewed to determine their perceptions of risks and benefits of cannabis use during pregnancy and postpartum. Qualitative description methodology was used to identify common themes in the data. Nineteen (n = 14 pregnant; n = 5 post-partum) women who used cannabis daily while pregnant were interviewed about perceptions of risks and benefits of cannabis use during pregnancy and postpartum.

Results:
Five themes, describing the participants’ cannabis use while pregnant and postpartum, emerged from the data. These themes include (1) continued use for health management, (2) ongoing evaluative process, (3) mixed messages, (4) wanting more information, and (5) legal considerations. All 5 of these themes contributed to the overarching theme of Taking Care of Mom and Baby, which encompasses the mother's need and struggle to care for her own health and wellness, as well as that of her unborn baby.

Conclusions:
In a state with legalized recreational cannabis, pregnant and postpartum women reported continuing daily cannabis use during pregnancy to take care of themselves and their baby. It is crucial for healthcare providers to follow national guidelines and explain risks of cannabis use during pregnancy and postpartum, while also managing expectations based on patient history. A harm reduction approach to decrease cannabis use is vital to help pregnant women who are using cannabis for health management to continuously evaluate their use during pregnancy and postpartum.