bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metastatic aneurysmal fibrous histiocytoma in a 20‐year‐old woman: A rare case report with review of the literature and discussion of its genomic features
Authors: Wood Kimberly A. , Easson Alexandra M. , Ghazarian Danny , Saeed Kamil Zaid 
Published: May 2020

AbstractAneurysmal fibrous histiocytoma is an uncommon variant of cutaneous fibrous histiocytomas with a local recurrence rate of 19%. We present a case of aneurysmal fibrous histiocytoma in a 20‐year‐old female with a regional lymph node metastasis and subsequent satellite nodule. The patient initially presented with a 1‐month history of two palpable nodules in left lower anterior shoulder and left axilla. Needle core biopsies from both lesions revealed an atypical spindle cell neoplasm with a differential diagnosis of aneurysmal fibrous histiocytoma and angiomatoid fibrous histiocytoma. The axillary dissection confirmed a metastatic deposit in 1 out of 22 lymph nodes. At 6 months a satellite nodule arose between the resection scar and the axilla histopathologically demonstrating a cellular spindle cell nodule at the dermis subcutaneous junction with large, blood‐filled pseudovascular spaces lined by histiocytes. The periphery of the lesion showed collagen trapping without a lymphoplasmacytic infiltrate. The lesional cells were diffusely positive for CD10 and focally for CD68 and Illumina RNA fusion panel sequencing was negative. Herein we present this case of metastatic aneurysmal fibrous histiocytoma with review of the literature and discussion of biology, cytogenetic alterations, and differential diagnosis.
Prevalence of residual inflammatory risk and associated clinical variables in patients with type 2 diabetes
Authors: Prattichizzo Francesco , Giuliani Angelica , Sabbatinelli Jacopo , Matacchione Giulia , Ramini Deborah , Bonfigli Anna Rita , Rippo Maria Rita , de Candia Paola , Procopio Antonio Domenico , Olivieri Fabiola , Ceriello Antonio 
Published: May 2020

AbstractResidual inflammatory risk (RIR) is defined as persistent circulating levels of high sensitivity C‐reactive protein (hs‐CRP) >2 mg/L despite an optimal (<70 mg/dL) control of LDL‐cholesterol (LDL‐C) and represents an emerging risk factor for the development of cardiovascular events in patients at high risk of atherosclerosis. Sparse data are available regarding the prevalence of RIR in patients with type 2 diabetes (T2D) and the clinical variables associated with hs‐CRP elevation. Here, we report data from a well‐characterized cohort of patients with T2D (n = 511) stratified for statins use, LDL‐C goal attainment and prevalent T2D complications. Statins use and having at‐target LDL‐C partially affect the number of patients with inflammatory risk when compared with the whole T2D population, with an RIR prevalence of 39.2%. Among the spectra of complications, only patients with nephropathy had a higher prevalence of inflammatory risk. Total cholesterol, non‐HDL‐cholesterol, triglycerides, body mass index and waist‐hip ratio were associated with hs‐CRP, with an increased magnitude in at‐target patients. Conversely, glucose‐related variables were strongly associated with hs‐CRP only in at‐target patients, overall suggesting glycaemic control, insulin resistance, non‐LDL‐C lipid variables and especially central obesity as possible contributors to RIR in patients with T2D and LDL‐C <70 mg/dL.
A 5‐HT1D‐receptor agonist protects Dravet syndrome mice from seizure and early death
Authors: Hatini Paul G. , Commons Kathryn G. 
Published: May 2020

AbstractMutations in the SCN1A gene encoding the Nav1.1 sodium channel cause several forms of epilepsy, the most severe is Dravet syndrome (DS). DS patients are at high risk for sudden death and seizures are often triggered by fever or hyperthermia. To improve understanding of how serotonergic ligands might influence DS in this study, we tested several drugs for their effect on hyperthermia‐induced seizure using a mouse model of DS consisting of a heterozygous loss of function of Scn1A. We found that a mixed 5‐HT2A/2C receptor agonist had no effect while a mixed 5‐HT1B/D receptor agonist had a modest effect reducing the severity of seizures. Hypothesizing selective agonists may be more effective, we tested selective 5‐HT1B and 5‐HT1D receptor agonists, CP‐93129 and GR‐46611, respectively. Of these GR‐46611 significantly increased the threshold of hyperthermia‐induced seizure and lowered seizure severity. Given chronically at 1 mg kg−1 day−1, GR‐46611 also significantly improved survival of DS mice. Thus, 5‐HT1D‐receptors may represent a meaningful target for pharmacotherapy for DS with potential relevance for related forms of epilepsy, particularly those with a known sensory trigger such as heat.
Is there evidence of bradykinesia in essential tremor?
Authors: Bologna M. , Paparella G. , Colella D. , Cannavacciuolo A. , Angelini L. , Alunni‐Fegatelli D. , Guerra A. , Berardelli A. 
Published: May 2020

Background and purposeEssential tremor (ET) is a movement disorder primarily characterized by upper limb postural and kinetic tremor. Although still under‐investigated, bradykinesia may be part of the phenotypic spectrum of ET. The aim was to evaluate bradykinesia features in ET through clinical examination and kinematic analysis of repetitive finger movements. Data collected in ET patients were compared with those recorded in Parkinson’s disease patients and healthy controls.MethodsOverall, 258 subjects participated in the study (90 ET patients, 84 Parkinson’s disease patients and 84 healthy controls). Repetitive finger tapping was kinematically recorded using a motion analysis system. Movement velocity, amplitude and decrement (sequence effect) were measured. The three groups were first compared by one‐way analysis of variance. A cluster analysis was also performed to better address the data variability observed in ET patients. Possible relationships between kinematic and clinical data were assessed in ET patients.ResultsEssential tremor patients were slower than healthy controls. Movement slowness in ET did not correlate with postural or kinetic tremor severity. It was also found that movement slowness in ET was not associated with a sequence effect, which instead is a common feature in Parkinson’s disease. Cluster analysis showed that a proportion of ET patients may have movement abnormalities similar to those observed in Parkinson’s disease.ConclusionsMovement slowness without sequence effect is a common feature in ET patients. The present findings are relevant when interpreted in the context of the new tremor classification system and in the development of a more accurate bradykinesia definition.
Religion and venture investing: A cross‐country analysis
Authors: Maung Min , Tang Zhenyang , Xu Xiaowei 
Published: May 2020

AbstractUsing a sample of 56 countries over the 2000–2016 period, we document lower levels of venture capital investments in more religious countries. These results are not specific to any primary religion. Furthermore, we show that the negative relation between religiosity and venture investing mainly stems from risk aversion inherent in religiosity. Our results are unlikely driven by economic clout, as we show more religious countries in fact have higher levels of domestic credit or nonfinancial investments, despite lower levels of venture investments. We also present several findings consistent with risk aversion. Venture investments in more religious countries are more likely to have successful exits and are less likely to be foreign or early‐stage deals. Our results are robust to different measures of venture investments and religiosity, and to alternative specifications that account for endogeneity.
Cross‐cultural adaptation and validation of Haem‐A‐QoL in Côte d'Ivoire
Authors: Lambert Catherine , Meité N'Dogomo , Sanogo Ibrahima , Lobet Sébastien , von Mackensen Sylvia , Hermans Cedric 
Published: May 2020

AbstractIntroductionHealth‐related quality (HRQoL) evaluations are considered essential outcomes in the assessment of people with haemophilia. In developing countries, reliable HRQoL data are even more critical whilst enabling government agencies to develop national haemophilia care programmes. However, validated tools are not yet available in sub‐Saharan African countries.AimsThis study sought to perform a cultural adaptation and validation of the Haemophilia Quality of Life Questionnaire for Adults (Haem‐A‐QoL) in Côte d'Ivoire.MethodsThe process comprised several steps, such as linguistic adaptation, cognitive debriefing interviews with adult haemophilia patients and psychometric testing, including reliability (internal consistency, test‐retest reliability) and validity assessments (convergent with EQ‐5D‐5L, criterion with HJHS 2.1, known‐groups).ResultsThe final Ivoirian Haem‐A‐QoL version was obtained in December 2017 following linguistic adaptation and cognitive debriefings with six participants. The validation process included 25 patients, mainly haemophilia A patients (88%) with severe forms (80%). All participants received on‐demand treatment, with joint impairment observed in 92%. Internal consistency and test‐retest reliability of the Ivoirian Haem‐A‐QoL were very good. A Pearson correlation analysis revealed a moderate negative correlation between EQ‐VAS and total Haem‐A‐QoL scores and a moderate positive correlation between HJHS 2.1 and total Haem‐A‐QoL scores.ConclusionsA cross‐culturally adapted and validated Haem‐A‐QoL version in Côte d'Ivoire is now available, enabling measurement of intervention outcomes in the targeted population and Ivorian participation to multisite international trials. However, further work is needed to ensure optimal understanding of HRQoL questionnaires, previously developed in culturally distinct countries, with almost unlimited access to different treatment regimens.
Invitation to trusteeship rather than treat? Higher Education, human rights and student litigation: A response to Fulford (2020)
Authors: Diver Alice 
Published: May 2020

AbstractThis article argues that, as tutors, we are bound not only by the rules of contract law (i.e., to avoid breaching the terms of that which was agreed to), but also by our duty of care, and the principles of human rights law that protect the right to education. We must strive to avoid negligent acts and any potentially harmful practices or policies. Looking to recent litigation, we are bound also to provide useful, meaningful guidance on how learners might best achieve—and subsequently evidence—high levels of intellectual attainment and wider ‘learning gains.’. The concepts of fairness and equitable treatment are key, especially where universities have agreed to widen access and improve opportunities. With the protection of vulnerable learners increasingly leaning towards the provisions—and promises—of human rights law, a sort of estoppel‐led ‘trusteeship’ (over shared knowledge and learning processes) can perhaps also be inferred.
Influence of microwave heating and time on functional, pasting and thermal properties of cassava starch
Authors: Oyeyinka Samson A. , Akinware Ruth O. , Bankole Aishat T. , Njobeh Patrick B. , Kayitesi Eugénie 
Published: May 2020

SummaryThe effect microwaving power and time on the functional, pasting and thermal properties of cassava starch was investigated. Cassava starch at a moisture content of 30% was microwaved at 600 and 700 W for 0, 5, 15, 30 and 60 s following a preliminary study. Microwaving power and time did not alter the crystalline pattern of the starch, but there were obvious changes in the starch morphology. Starch colour was significantly (P ≤ 0.05) altered by microwave heating, with the total colour difference increasing from 4.85 to 43.01. Microwave treatment increased starch gelatinisation temperatures but decreased the swelling power, water absorption capacity and the relative crystallinity. These changes were influenced by microwave heating power and time. The results further revealed that the peak viscosity (3714.00–1947.00 cP) and setback ratio (1.70–1.49) decreased with increasing microwave heating time. However, breakdown viscosity (322.67–897.63 cP) and pasting temperature (1947.00–3714.00 °C) increased.
Hyperspectral imaging for discrimination of Keemun black tea quality categories: Multivariate calibration analysis and data fusion
Authors: Ren Guangxin , Liu Ying , Ning Jingming , Zhang Zhengzhu 
Published: May 2020

SummaryFood fraud causes significant economic losses for the industry and generates distrust between the consumers and traders. Tea is one of the most valued beverages throughout the world, being vulnerable to economically motivated cheat. The objective of the study was to develop the potential of hyperspectral imaging (HSI) allying multivariate analysis and data fusion to identify the authenticity of Keemun black tea quality categories. Data fusion that integrated of texture characteristics based on grey level co‐occurrence matrix and visible and near‐infrared spectral features via competitive adaptive reweighted sampling (CARS) was as the target data for modelling. Support vector machine (SVM) and random forest (RF) were utilised for the classification of tea samples of seven grades. The RF model using fused data gave the best performance with the correct discriminant rate of 92.70% for the prediction set. This study demonstrated that HSI coupled with RF was effective in identifying tea sample rank.
The Double Face of Christian Mission and Education in India from Dalit and Decolonial Perspectives
Authors: Sigamoney Shakespeare 
Published: May 2020

AbstractMissionaries from Europe came to India starting in the 15th century to preach the gospel. Their mission works have both intended and unintended consequences that affect people even today. Missionaries brought modern education to India and gave Western education to Dalits, leading to the social uplifting of Dalits, who were denied education by the oppressive caste system. Some missionaries also spoke against the social evils during their time. On the other hand, some missionaries’ work at times highlighted the Brahmanic religion as a pan‐India religion which placed popular religions in a disadvantaged position. Furthermore, their work also helped the British colonial government to maintain control and become powerful. The translation work of the missionaries and the educational institutions helped the colonial government to strengthen its control over the local population. This article discusses the mission work of Robert de Nobili, Bartholomew Ziegenbalg, and William Carey and evaluates their mission works from Dalit and decolonial perspectives.
“Together towards a Banquet”: The Feast as Promise and Resistance in Together Towards Life and Contemporary Theological Discourse
Authors: Bargár Pavol 
Published: May 2020

AbstractThis article explores the symbol of the feast, as proposed by the 2012 World Council of Churches’ affirmation Together towards Life: Mission and Evangelism in Changing Landscapes (TTL). The feast is introduced as an appropriate hermeneutic tool to account for the multi‐layered and dynamic reality of human life in the presence of others and in the presence of God. Interpreting the feast, together with TTL, as a symbol of the liberation and reconciliation of the whole creation and of the celebration of life in response to the outreaching love of God, the article reflects on some contemporary theological voices arguing that God’s invitation to the feast of God’s kingdom is a central element of Christian existence. Such feasting is, among other things, characterized by the dynamics of facing, the presence of the other, the awareness of human corporeality, and the particularization of the other that can overcome the idolatrous power of death. Entering this conversation, the present article will argue that the symbol of the feast can helpfully be understood in its two‐fold dynamics of promise and resistance. While giving assurance about the transformation of all reality in the coming reign of justice and peace, the symbol of the feast, with its emphasis on inclusiveness and equality, also empowers people to resist all life‐denying forces. Walking with the rest of the creation “together towards a banquet,” Christians are thus enabled, it will be asserted, to discern and actively live their vocation.
The prevalence, characteristics, and related factors of pressure injury in medical staff wearing personal protective equipment against COVID‐19 in China: A multicentre cross‐sectional survey
Authors: Jiang Qixia , Liu Yuxiu , Wei Wei , Zhu Dongmei , Chen Aihua , Liu Haiying , Wang Jing , Jiang Zhixia , Han Qiuying , Bai Yuxuan , Hua Jiao , Zhang Yanhong , Guo Jinli , Li Li , Li Juan 
Published: May 2020

AbstractSince December 2019, the medical staff fighting against COVID‐19 frequently reported the device‐related pressure injury (DRPI) caused by personal protective equipment (PPE). We conducted a cross‐sectional survey online to investigate the prevalence and characteristics of DRPI among medical staff. Univariate and multivariate logistic regression analyses were employed to explore the risk factors associated with DRPI. A total of 4308 participants were collected and 4306 participants were valid from 161 hospitals in China. The overall prevalence of DRPI caused by PPE among medical staff was 30.03% (95% CI 28.69%‐31.41%). The prevalence of male was more than that of female (42.25%, 95% CI 37.99‐46.51% vs 26.36%, 95% CI 26.93‐29.80%, P < .001).The categories were mainly stages 1 and 2, and the common anatomical locations were nose bridge, cheeks, ears, and forehead. Logistic regression analysis revealed that the risk factors were sweating (OR = 43.99, 95% CI 34.46‐56.17), male (OR = 1.50, 95% CI 1.12‐1.99), level 3 PPE (OR = 1.44, 95% CI 1.14‐1.83), and longer wearing time (OR = 1.28, 95% CI 0.97‐1.68). The prevalence of DRPI was high among medical staff wearing PPE against COVID‐19, and the risk factors were sweating, male, wearing level 3 PPE, and longer wearing time. Comprehensive preventive interventions should be taken.
Diagnostic classification of irritability and oppositionality in youth: a global field study comparing ICD‐11 with ICD‐10 and DSM‐5
Authors: Evans Spencer C. , Roberts Michael C. , Keeley Jared W. , Rebello Tahilia J. , de la Peña Francisco , Lochman John E. , Burke Jeffrey D. , Fite Paula J. , Ezpeleta Lourdes , Matthys Walter , Youngstrom Eric A. , Matsumoto Chihiro , Andrews Howard F. , Elena Medina‐Mora María , Ayuso‐Mateos José L. , Khoury Brigitte , Kulygina Mayya , Robles Rebeca , Sharan Pratap , Zhao Min , Reed Geoffrey M. 
Published: May 2020

BackgroundSevere irritability has become an important topic in child and adolescent mental health. Based on the available evidence and on public health considerations, WHO classified chronic irritability within oppositional defiant disorder (ODD) in ICD‐11, a solution markedly different from DSM‐5’s (i.e. the new childhood mood diagnosis, disruptive mood dysregulation disorder [DMDD]) and from ICD‐10’s (i.e. ODD as one of several conduct disorders without attention to irritability). In this study, we tested the accuracy with which a global, multilingual, multidisciplinary sample of clinicians were able to use the ICD‐11 classification of chronic irritability and oppositionality as compared to the ICD‐10 and DSM‐5 approaches.MethodsClinicians (N = 196) from 48 countries participated in an Internet‐based field study in English, Spanish, or Japanese and were randomized to review and use one of the three diagnostic systems. Through experimental manipulation of validated clinical vignettes, we evaluated how well clinicians in each condition could identify chronic irritability versus nonirritable oppositionality, episodic bipolar disorder, dysthymic depression, and normative irritability.ResultsCompared to ICD‐10 and DSM‐5, ICD‐11 led to more accurate identification of severe irritability and better differentiation from boundary presentations. Participants using DSM‐5 largely failed to apply the DMDD diagnosis when it was appropriate, and they more often applied psychopathological diagnoses to developmentally normative irritability.ConclusionsThe formulation of irritability and oppositionality put forth in ICD‐11 shows evidence of clinical utility, supporting accurate diagnosis. Global mental health clinicians can readily identify ODD both with and without chronic irritability.
FHA2 is a plant‐specific ISWI subunit responsible for stamen development and plant fertility
Authors: Gu Bo‐Wen , Tan Lian‐Mei , Zhang Cui‐Jun , Hou Xiao‐Mei , Cai Xue‐Wei , Chen She , He Xin‐Jian 
Published: May 2020

AbstractImitation Switch (ISWI) chromatin remodelers are known to function in diverse multi‐subunit complexes in yeast and animals. However, the constitution and function of ISWI complexes in Arabidopsis thaliana remain unclear. In this study, we identified forkhead‐associated domain 2 (FHA2) as a plant‐specific subunit of an ISWI chromatin‐remodeling complex in Arabidopsis. By in vivo and in vitro analyses, we demonstrated that FHA2 directly binds to RLT1 and RLT2, two redundant subunits of the ISWI complex in Arabidopsis. The stamen filament is shorter in the fha2 and rlt1/2 mutants than in the wild type, whereas their pistil lengths are comparable. The shorter filament, which is due to reduced cell size, results in insufficient pollination and reduced fertility. The rlt1/2 mutant shows an early‐flowering phenotype, whereas the phenotype is not shared by the fha2 mutant. Consistent with the functional specificity of FHA2, our RNA‐seq analysis indicated that the fha2 mutant affects a subset of RLT1/2‐regulated genes that does not include genes involved in the regulation of flowering time. This study demonstrates that FHA2 functions as a previously uncharacterized subunit of the Arabidopsis ISWI complex and is exclusively involved in regulating stamen development and plant fertility.
Vermilionectomy followed by reconstruction of the vermilion mucosa using allograft dermal matrix in patients with actinic cheilitis of the lower lip
Authors: Chang Shao‐hai , Huang Zhuo‐shan , Chen Wei‐liang , Zhou Bin , Zhong Jiang‐long 
Published: May 2020

AbstractBackgroundWhen treating actinic cheilitis (AC), it is essential to minimize the risk of malignant transformation (MT) and maintain lip functionality and cosmesis.AimsWe evaluated the outcomes of vermilionectomy followed by reconstruction of the vermilion mucosa using allograft dermal matrix (ADM) in patients with AC of the lower lip.Materials and methodsWe evaluated eight patients with lower lip AC who underwent vermilion mucosa reconstruction using ADM after vermilionectomy. We enrolled five males and three females ranging in age from 55 to 70 years (mean, 62.1 years). The ADM ranged in area from 1.3 × 5.0 to 1.7 × 5.8 cm (median, 1.6 × 5.5 cm). All patients were followed up for at least 3 months postoperatively by a panel of three surgeons who assessed the esthetic results, and orbicularis oris and speech functions.ResultsAll patients underwent successful reconstruction of the vermilion mucosa using ADM after vermilionectomy, without complications. The postoperative esthetic results, and the orbicularis oris and speech functions, were satisfactory to excellent in all patients. Patients were followed up for 18‐38 months (median, 26.1 months). No MT or recurrence was noted.ConclusionsVermilionectomy followed by reconstruction of the vermilion mucosa with ADM is safe and feasible for AC patients.