bluuebunny/crossref_metadata_2025_split huggingface dataset:
SISTEM INFORMASI PENDAFTARAN PASIEN PADA KLINIK dr. VERI KAJEN KABUPATEN PEKALONGAN BERBASIS ANDROID
Authors: Aslam Fatkhudin Aslam , Alifiani Dwi Nur 
Published: December 2020

ABSTRAK Tuntutan pelayanan dan pengelolaan informasi secara terintegrasi menjadi sangat penting di setiap lembaga, termasuk di suatu klinik. Klinik dr. Veri merupakan sebuah balai pengobatan yang ada diwilayah Kajen, tepatnya dijalan Mandurorejo Nomor. 359 Kajen. Pendaftaran yang ada pada klinik dr. Veri saat ini masih menggunakan sistem manual yaitu dengan cara pasien datang secara langsung ke Klinik untuk melakukan pendaftaran agar mendapatkan nomor antrian dan akan membutuhkan waktu yang lama untuk mengantri.Untuk mengatasi permasalahan diatas, Klinik tersebut membutuhkan sebuah Sistem Informasi Pendaftaran Pasien. Sistem ini dibuat dengan beberapa fasilitas-fasilitas yang dapat digunakan, diantaranya untuk mendaftar periksa dan juga ada pemberitahuan untuk mengetahui nomor antrian. Sistem ini berbasis android dengan platform ionic, bahasa pemrograman AngularJs dan PHP, serta database menggunakan MySQL. Hasil penelitian ini adalah sistem informasi pendaftaran pasien pada klinik dr. Veri berbasis android yang dapat dijaadikan sebagai sarana pelayanan dan media informasi bagi masyarakat, yang memiliki beberapa fitur yang dapat digunakan untuk mendaftar periksa.
IMPLEMENTASI METODE SAW DALAM SISTEM PENDUKUNG KEPUTUSAN PEMILIHAN MODEL SOCIAL CUSTOMER RELATIONSHIP MANAGEMENT
Authors: Rusliyawati Rusliyawati , Damayanti Damayanti , Prawira Sefrizal Nata 
Published: December 2020

Pertumbuhan dan perkembangan internet serta sosial media yang berkembang pesat memunculkan perkembangan baru dari Customer Relationship Management (CRM) yaitu Social Customer Relationship Management (SCRM) yang menuntut organisasi menetapkan arah strategi bisnis dengan pengaplikasian teknologi sesuai kebutuhan dalam berbagai aktivitas sehingga mampu meningkatkan perubahan bisnis skala besar melalui kecepatan, ketepatan dan efisiensi dari pertukaran informasi. Kualitas strategi bisnis yang baik dapat dilakukan dengan cara penyediaan fasilitas berbasis media sosial dengan pertimbangan yang sangat matang yaitu dengan cara menilai berbagai indikator penilaian yang sudah ditentukan terhadap sosial media yang dapat memberikan kontribusi yang baik bagi perusahaan sebagai salah satu strategi bisnis yang dipilih oleh perusahaan. Tujuan penelitian ini untuk menganalisis perhitungan karakteristik dari setiap model social customer relationship management (SCRM) sebagai strategi bisnis dengan menggunakan metode pendekatan Simple Additive Weighting (SAW). Hasil penelitian menunjukan bahwa media sosial Youtube dengan perolehan nilai 0,888 adalah media sosial yang direkomendasikan untuk digunakan sebagai strategi bisnis perguruan tinggiKata Kunci: Social Customer Relationship Management, Simple Additive Weighting, Strategi Bisnis
Effect of Electrolyte Composition on Structural and Photoelectrochemical Properties of Titanium Dioxide Nanotube Arrays Synthesized by Anodization Technique
Authors: Awaid Tabarak Jafar , Ayal Asmaa Kadim , Farhan Ahlam Mohammed , Sando Muna Sarhan , Chin Lim Ying 
Published: December 2020

The present work involves studying the effect of electrolyte composition [@1= 0.5 wt.% NH4F / 5% H2O / 5% Glycerol (GLY)/ 90% Ethylene Glycol (EG)] and [ @2= 0.5 wt. % NH4F / 5% H2O / 95% Ethylene Glycol (EG)] on the structural and photoelectrochemical properties of titania nanotubes arrays (TNTAs). TNTAs substrates were successfully carried out via anodization technique and were carried out in 40 V for one hour in different electrolytes (@1, and @2). The properties of physicochemical of TNTAs were distinguished via an X-ray Diffractometer (XRD), Field Emission Scanning Electron Microscope (FESEM), an Energy Dispersive X-ray (EDX), and UV–visible diffuse reflectance. The photoelectrochemical response of TNTAs was evaluated in 0.01M Na2S under the choppy light of a halogen lamp. TNTAs photoelectrode prepared at @1 electrolyte was not sufficient to increase the photocurrent response compared to TNTAs prepared at @2. The TNTAs photoelectrode prepared in the @2 electrolyte confirmed the highest photoconversion efficiency compared to the TNTAs photoelectrode prepared in the @1 electrolyte.
Combining Several Substitution Cipher Algorithms using Circular Queue Data Structure
Authors: Ibraheem Noor , Hasan Mokhtar 
Published: December 2020

With the revolutionized expansion of the Internet, worldwide information increases the application of communication technology, and the rapid growth of significant data volume boosts the requirement to accomplish secure, robust, and confident techniques using various effective algorithms. Lots of algorithms and techniques are available for data security. This paper presents a cryptosystem that combines several Substitution Cipher Algorithms along with the Circular queue data structure. The two different substitution techniques are; Homophonic Substitution Cipher and Polyalphabetic Substitution Cipher in which they merged in a single circular queue with four different keys for each of them, which produces eight different outputs for every single incoming letter. The present work can be applied efficiently for personal information security and network communication security as well, and the time required for ciphering and deciphering a message is less than 0.1 sec.
Sea-ice retreat may decrease carbon export and vertical microbial connectivity in the Eurasian Arctic basins
Authors: Fadeev Eduard , Rogge Andreas , Ramondenc Simon , Nöthig Eva-Maria , Wekerle Claudia , Bienhold Christina , Salter Ian , Waite Anya , Hehemann Laura , Boetius Antje , Iversen Morten 
Published: December 2020

Abstract
Arctic Ocean sea-ice cover is shrinking due to warming. Long-term sediment trap data show higher export efficiency of particulate organic carbon in regions with seasonal sea-ice compared to regions without sea-ice. To investigate this sea-ice enhanced export, we compared how different phytoplankton communities in seasonally ice-free and ice-covered regions of the Fram Strait affect carbon export and vertical dispersal of microbes. In situ collected aggregates, combined with microbial source tracking revealed that larger aggregates from sea-ice and under-ice diatom blooms were responsible for higher export efficiency and vertical microbial connectivity. During early summer, Phaeocystis aggregates dominated the ice-free regions and exported two-fold less carbon than diatom aggregates in ice-covered regions, and also less surface-born microbial clades to the deep-sea. This suggests that continuous ice-loss will further decrease pelagic-benthic coupling, impacting the quantity and quality of food input due to formation of slow-settling aggregates, with potential repercussions for Arctic deep-sea ecosystems.
Out-of-plane emission of trions in monolayer WSe2 revealed by whispering gallery modes of dielectric microresonators
Authors: Andres-Penares Daniel , Hábil Mojtaba Karimi , Molina-Sánchez Alejandro , Zapata-Rodríguez Carlos , Martinez-Pastor Juan , Sánchez-Royo Juan 
Published: December 2020

Abstract
The manipulation of light emitted by two-dimensional semiconductors grounds forthcoming technologies in the field of on-chip communications. However, these technologies require from the so elusive out-of-plane photon sources to achieve an efficient coupling of radiated light into planar devices. Here we propose a versatile spectroscopic method that enables the identification of the out-of-plane component of dipoles due to the selective coupling of light emitted by in-plane and out-of-plane dipoles to the whispering gallery modes of spherical dielectric microresonators, in close contact to them. We have applied this method to demonstrate the existence of dipoles with an out-of-plane orientation in monolayer WSe2 at room temperature, by means of micro-photoluminescent measurements, numerical simulations based on finite element methods, and ab-initio calculations. Experimental results and ab-initio calculations identify trions as the source responsible for this out-of-plane emission, opening new routes for realizing on-chip integrated systems with applications in information processing and quantum communications.
The Role of Undegraduate Medical Students Training in Respect for Patient Confidentiality
Authors: Beltran-Aroca Cristina M , Ruiz-Montero Rafael , Labella Fernando , Girela-López Eloy 
Published: December 2020

Abstract
IntroductionEncouraging professional integrity is vital in providing a standard of excellence in the quality of medical care and education, promoting a culture of respect and responsibility. The main objective of this work consisted of studying the relationship of medical students with the right to privacy of patients in Spain, specifically analysing the conditions of accessing patients’ Clinical History (CH).MethodsA questionnaire was sent to final-year students at 41 Spanish universities. It had 14 multiple choice questions framed in 3 large blocks. The first one addressed basic general knowledge issues on the right to privacy and the obligation of confidentiality. The two remaining blocks were made up of questions directed towards evaluating the frequency with which certain requirements and steps of action related to the students in attending the patient were performed, and regarding the guarantees in accessing and handling their CH both on paper and in the Electronic Medical Record.ResultsA total of 245 valid replies was considered. 67.8% of participants were women, with an average age of 24.05±3.49 years. Up to 90.6% were aware that confidentiality affected the data in CHs, although 43.3% possessed non-anonymized photocopies of patients’ clinical reports outside healthcare context, and only 49.8% of the students were always adequately identified. 59.2% accessed patients’ CHs on some occasions by using passwords of healthcare professionals and 77.2% of them did not have patients’ express consent and 71.9% accessed a CH that was not anonymised.ConclusionsThe role of healthcare institutions and universities is considered to be fundamental in implementing educational measures regarding the risks and ethical and legal problems arising from the use of CHs among professionals and students. A profound study of medical ethics is needed through the analysis of clinical cases, and direct exposure to situations in which the patient’s confidentiality is questioned.
Microwave-Assisted One Pot Three-Component Synthesis of Novel Bioactive Thiazolyl-pyridazinediones As Potential Antimicrobial Agents against Antibiotic-Resistant Bacteria
Authors: Abu-Melha Saraa , Gomha Sobhi , Abouzid Amr , Edrees Mastoura , Dena Ahmed Abo , Muhammad Zeinab 
Published: December 2020

Abstract

Novel 2-thiazolyl-pyridazinedione derivatives were prepared via multicomponent synthesis under microwave irradiation as ecofriendly energy source and using the eco-friendly naturally occurring chitosan basic catalyst with high/efficient yields and short reaction time. All the prepared compounds were fully characterized by spectroscopic methods, and their in-vitro biological activities were investigated. The obtained results were compared with those of standard antibacterial/antifungal agents. DFT calculations and molecular docking studies were used to investigate the electronic properties and molecular interactions with specific microbial receptors.
Accurate Detection and Quantification of Seasonal Abundance of American Bullfrog (Lithobates Catesbeianus) Using ddPCR eDNA Assays
Authors: Everts Teun , Halfmaerten David , Neyrinck Sabrina , De Regge Nico , Jacquemyn Hans , Brys Rein 
Published: December 2020

Abstract
The invasive American bullfrog (Lithobates catesbeianus) imperils freshwater biodiversity worldwide. Effective management includes rapid detection and response to incipient invasions, as established populations are extremely difficult to eradicate. Although environmental DNA (eDNA) approaches provide a highly sensitive alternative to conventional surveillance techniques, extensive testing is paramount to generate reliable output. Here, we tested and compared the performance of two primer/probe assays to detect and quantify the abundance of bullfrogs in silico and in situ using digital droplet PCR. Although both assays proved to be equally specific and sensitive, one outperformed the other in detection resolution (i.e. distinguishing target and non-target droplets), and hence was selected for further analyses. Mesocosm experiments using density series of larval and juvenile bullfrogs revealed that eDNA concentrations could explain 99% of the larval abundance and biomass. Per individual eDNA emission rates did not differ significantly among life stages, indicating that eDNA concentrations can be used as a reliable proxy to asses bullfrog abundance in natural populations. Seasonal eDNA patterns in three infested ponds showed parallel fluctuations in bullfrog eDNA concentrations. A peak in late summer (August, September or October), coinciding with the breeding season, was followed by continuously low eDNA concentrations in winter and spring. These findings demonstrate that eDNA analyses can be used as a solid and reliable tool to detect the early stages of bullfrog invasions and to quantify temporal changes in abundance that will be useful in coordinating and evaluating large-scale bullfrog eradication programs.
Effect of six weeks 1000 mg/day Vitamin C supplementation and healthy training in elderly women on genes expression associated with immune response - a randomized controlled trial
Authors: Żychowska Małgorzata , Grzybkowska Agata , Zasada Mariusz , Piotrowska Anna , Dworakowska Danuta , Czerwinska-Ledwig Olga , Pilch Wanda , Antosiewicz Jędrzej 
Published: December 2020

Abstract
BackgroundIn this study we investigated the effects of supplementation and exercise on the expression of genes associated with inflammation like CCL2, CRP, IL1, IL6, IL10 mRNA in elderly women.MethodsTwenty four participants divided randomly into two groups were subjected to 6 weeks of the same health training program (three times per week). SUP group (supplemented, n = 12, mean age 72.8 ± 5.26 years and mean body mass 68.1 ± 8.3 kg) received 1000 mg of Vitamin C/day during training period, while CON group (control, n = 12, mean age 72.4 ± 5.5 years and body mass 67.7 ± 7.5 kg) received placebo.ResultsNo significant changes in IL-1, IL-6, IL-10 and CRP mRNA were observed within and between groups. However, there was a clear tendency of a decrease in IL-6 (two-way ANOVA, significant for time) and an increase in IL-10 mRNA noted in the supplemented group. A significant decrease in CCL2 mRNA was observed only in the CON group (from 2^0.2 to 2^0.1, p = 0.01).ConclusionsIt can be concluded, that 6 weeks of supplementation and exercise was too short to obtain significant changes in gene expression in leukocytes, but supplementation of 1000 mg vitamin C positively affected IL-6 and IL-10 expression – which are key changes in the adaptation to training. However, changes in body mass, IL1 and CCL2 was positive in CON group. It is possible that Vitamin C during 6 weeks of supplementation could have different effects on the expression of individual genes involved in immune response.Trial registration: retrospectively registered.
Network machine learning maps phytochemically-rich “Hyperfoods” to fight COVID-19
Authors: Laponogov Ivan , Gonzalez Guadalupe , Shepherd Madelen , Qureshi Ahad , Veselkov Dennis , Charkoftaki Georgia , Vasiliou Vasilis , Youssef Jozef , Mirnezami Reza , Bronstein Michael , Veselkov Kirill 
Published: December 2020

Abstract
In this paper, we introduce a network machine learning method to identify potential bioactive anti-COVID-19 molecules in foods based on their capacity to target the SARS-CoV-2-host gene-gene (protein-protein) interactome. Our experiments were run using a supercomputing DreamLab App platform, harnessing the idle computational power of thousands of smartphones. Machine learning models were initially calibrated by demonstrating that the proposed method can predict anti-COVID-19 candidates among experimental and clinically approved drugs (5658 in total) targeting COVID-19 interactomics with the balanced classification accuracy of 80-85% in 5-fold cross-validated settings. This identified the most promising drug candidates that can be potentially “repurposed” against COVID-19 including common drugs used to combat cardiovascular and metabolic disorders, such as simvastatin, atorvastatin and metformin. A database of 7694 bioactive food-based molecules was run through the calibrated machine-learning algorithm, which identified 52 biologically active molecules, from varied chemical classes, including flavonoids, terpenoids, coumarins and indoles predicted to target SARS-CoV-2-host interactome networks. This in turn was used to construct a “food map” with the theoretical anti-COVID-19 potential of each ingredient estimated based on the diversity and relative levels of candidate compounds with antiviral properties. We expect this in-silico predicted food map to play an important role in future clinical studies of precision nutrition interventions against COVID-19 and other viral diseases.
The Long Noncoding RNA Differential Expression in Peripheral Blood Leukocyte from Schizophrenia Patients by RNA Sequencing
Authors: Wu Jie , Liu Zijun , Zhang Yunqiao , Teng Zhaowei , You Xu , Ruan Ye , Gao Changqing , Zeng Yong , Teng Zhaowei 
Published: December 2020

Abstract
Background: The diagnosis of schizophrenia (SCZ) depends on the evaluation of clinical symptoms, and there is no objective biomarker. Surveys have found that long non-coding RNA (lncRNA) may be affected in the pathogenesis of SCZ. There are also different genes in the expression of peripheral blood (PBL) in SCZ patients.Methods: We profiled transcriptome analysis of PBL in 50 patients with schizophrenia and 50 controls without psychiatric diagnoses, reconstructed PBL transcriptome information using RNA-seq, predicted lncRNA-mRNA interaction via “RNAplex”, a hierarchical classification-Spielman correlation coefficient approach was used to analyze the correlation between lncRNA and protein-coding gene expression among samples, and used systematic bioinformatics methods (Go/Pathway) to perform lncRNA functional annotation and qPCR experimental verification. Predicting functional sites for sequences using the database PROSITE, NCBI, UCSC, JASPAR.Results: We screened 94 lncRNA and 1179 mRNA differential expressions in PBL, of which 46 new lncRNAs were identified for the first time. Enrichment into lncRNA involves biological processes and signaling pathways related to the neutrophil activation involved in immune response. According to Spearman correlation coefficient analysis, 81 lncRNA and 410 mRNA have expression correlation (p<0.01 and |r|≥0.4), QPCR in independent samples verified that the core node of the lncRNA-mRNA co-expression network IL1RAP-TCONS_00138311 variable shear is indeed highly expressed in SCZ patients, 2^-△△Ct is 0.56, the area under the ROC curve is 0.924. The top four ranked transcription factors were predicted to be HSF1, HSF2, HSF4, and FOXA1.Conclusions: Combined with sequence function analysis, it showed that the transcription factors FOXA1, HSF1, HSF2, HSF4, etc. may mediate the activation of IL1B-induced NF-kβ pathway and other inflammatory pathways through the regulation of IL1RAP alternative splicing transcripts TCONS_00138311, thereby participating in the pathogenesis of SCZ. We propose that the frequency of Differential lncRNA in peripheral blood could be used as novel biomarker for distinguishing SCZ from health.
Exploiting the Anticancer Effects of a Nitrogen Bisphosphonate Nanomedicine for Glioblastoma Multiforme
Authors: Jena Lynn , Bennie Lindsey , McErlean Emma , Pentlavalli Sreekanth , Thakur Raj , Burrows James , Kett Vicky , Buckley Niamh , Coulter Jonathan , Dunne Nicholas , McCarthy Helen O 
Published: December 2020

Abstract
Glioblastoma multiforme (GBM) is an incurable aggressive brain cancer in which current treatment strategies have demonstrated limited survival benefit. In recent years, nitrogen-containing bisphosphonates (N-BPs) have demonstrated direct anticancer effects in a number of tumour types including GBM. In this study, a nano-formulation with the RALA peptide was used to complex the N-BP, alendronate (ALN) into nanoparticles (NPs) <200 nm for optimal endocytic uptake. Fluorescently labelled AlexaFluor®647 Risedronate was used as a fluorescent analogue to visualise the intracellular delivery of N-BPs in both LN229 and T98G GBM cells. RALA NPs were effectively taken up by GBM where a dose-dependent response was evidenced with potentiation factors of 14.96 and 13.4 relative to ALN alone after 72 h in LN229 and T98G cells, respectively. Furthermore, RALA/ALN NPs at the IC50, significantly decreased colony formation, induced apoptosis and slowed spheroid growth in vitro. In addition, H-Ras membrane localisation was significantly reduced in the RALA/ALN groups compared to ALN or controls, indicative of prenylation inhibition. The RALA/ALN NPs were lyophilised to enhance stability without compromising the physiochemical properties necessary for functionality, highlighting the suitability of the NPs for scale-up and in vivo application. Collectively, these data show the significant potential of RALA/ALN NPs as novel therapeutics in the treatment of GBM.
Simultaneous acquisition of current and lateral force signals during atomic force microscopy for characterising the piezoelectric and triboelectric effects of ZnO nanorods
Authors: Yang Yijun , Kim Kwanlae 
Published: December 2020

Abstract
Atomic force microscopy (AFM) is central to investigating the piezoelectric potentials of one-dimensional nanomaterials. The AFM probe is used to deflect individual piezoelectric nanorods and to measure the resultant current. However, the torsion data of AFM probes have not been exploited to elucidate the relationship between the applied mechanical force and resultant current. In this study, the effect of the size of ZnO nanorods on the efficiency of conversion of the applied mechanical force into current was investigated by simultaneously acquiring the conductive AFM and lateral force microscopy signals. The conversion efficiency was calculated based on linear regression analysis of the scatter plot of the data. This method is suitable for determining the conversion efficiencies of all types of freestanding piezoelectric nanomaterials grown under different conditions. A pixel-wise comparison of the current and lateral force images elucidated the mechanism of current generation from dense arrays of ZnO nanorods. The current signals generated from the ZnO nanorods by the AFM probe originated from the piezoelectric and triboelectric effects. The current signals contributed by the triboelectric effect were alleviated by using an AFM probe with a smaller spring constant and reducing the normal force.