bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cultural Adaptation and Validation of the Methotrexate Intolerance Severity Score in Brazilian Portuguese for Adults With Rheumatoid Arthritis
Authors: Amaral Jéssica Martins , Brito Maria José Menezes , Kakehasi Adriana Maria 
Published: November 2019

Introduction
The Methotrexate Intolerance Severity Score (MISS) questionnaire is used to identify intolerance to methotrexate (MTX), but it is not available in the Brazilian Portuguese language.

Objective
The aim of this study was to adapt and validate the MISS in Brazilian Portuguese.

Methods
The Brazilian Portuguese version of the MISS was developed following the Guidelines for the Process of Cross-cultural Adaptation of Self-report Measures. The new version was tested in 120 patients with rheumatoid arthritis. For the reliability assessment, the Cronbach α coefficient was used. The receiver operating characteristic curve was constructed with the objective of finding the best cutoff point for MTX intolerance and weighing the sensitivity and specificity. The concordance among the results was analyzed using the κ coefficient and factorial analysis with varimax rotation.

Results
This methodological study developed and applied a culturally acceptable Brazilian Portuguese version of the MISS. The MISS questionnaire presented internal consistency classified as “very good” because Cronbach α is equal to 0.83 (95% confidence interval, 0.79–0.87). The suitability of the data for factorial analysis was demonstrated using the Kaiser-Meyer-Olkin sample adequacy test (KMO = 0.723) and Bartlett sphericity test (χ2 = 499.98, p < 0.001). It was observed that a factorial analysis with 3 factors is preferred; the receiver operating characteristic curve of the MISS score was considered the cutoff point at 6 points (sensitivity 100% and specificity 89.4%).

Conclusions
The Brazilian Portuguese version of the MISS is valid and reliable for the detection of MTX intolerance in clinical practice.
Hepatobiliary Scintigraphy—Role in Preliminary Diagnosis and Management of Biliary Tract Injuries
Authors: Kousik Vankadari , Bhattacharya Anish , Yadav Thakur Deen , Mittal Bhagwant Rai 
Published: November 2019

Purpose
This study was conducted to identify the role of hepatobiliary scintigraphy (HBS) in the management of biliary tract injuries.

Methods
We retrospectively studied 54 patients (28 male and 26 female patients) aged 3 to 78 years with evidence of bile leak on HBS performed between January 2015 and October 2017. Following intravenous injection of 99mTc-mebrofenin, dynamic images were acquired for 30 minutes followed by static images until 24 hours. SPECT/CT was performed in patients with suspicion of bile leak on the planar images. Patients were classified as those with free intraperitoneal or localized bile leak. Any abdominal drain output was documented, and its statistical significance was assessed using Mann-Whitney U test. Subsequent management was also documented.

Results
Of the 54 patients, 28 demonstrated free intraperitoneal bile leak and 26 localized leak on HBS. Thirty-four patients (24 with free intraperitoneal leak and 10 with localized leak) had an abdominal drain. Drain output was significantly higher in patients with free intraperitoneal leak compared with patients with localized leak (370 vs 78 mL/d per patient, P < 0.01). All patients with free intraperitoneal bile leak underwent interventional procedures such as endoscopic retrograde cholangiopancreatography and stenting or Roux-en-Y hepaticojejunostomy later on. Patients with localized bile leak were managed conservatively and were free of symptoms at 1-year follow-up.

Conclusions
Our findings indicate that, in addition to detecting biliary leak, HBS may be used to identify patients with localized bile leak (48% of patients in our study) who do not require active intervention.
Immunological mechanisms in poststroke dementia
Authors: Doyle Kristian P. , Buckwalter Marion S. 
Published: November 2019

Purpose of review
To review new evidence on links between poststroke dementia and inflammation.

Recent findings
Although there are still no treatments for poststroke dementia, recent evidence has improved our understanding that stroke increases the risk of incident dementia and worsens cognitive trajectory for at least a decade afterwards. Within approximately the first year dementia onset is associated with stroke severity and location, whereas later absolute risk is associated with more traditional dementia risk factors, such as age and imaging findings. The molecular mechanisms that underlie increased risk of incident dementia in stroke survivors remain unproven; however new data in both human and animal studies suggests links between cognitive decline and inflammation. These point to a model where chronic brain inflammation, provoked by inefficient clearance of myelin debris and a prolonged innate and adaptive immune response, causes poststroke dementia. These localized immune events in the brain may themselves be influenced by the peripheral immune state at key times after stroke.

Summary
This review recaps clinical evidence on poststroke dementia, new mechanistic links between the chronic inflammatory response to stroke and poststroke dementia, and proposes a model of immune-mediated neurodegeneration after stroke.
Loops linking secondary structure elements affect the stability of molten globule intermediate state of apomyoglobin
Authors: Majorina M.A. , Melnik B.S. 
Published: November 2019

AbstractApomyoglobin is a protein widely used as a model for studying globular protein folding. This work aimed to test the hypothesis on influence of rigidity and length of loops linking protein secondary structure elements on the stability of molten globule intermediate state. For this purpose, we studied folding/unfolding of mutant apomyoglobin forms with substitutions of proline residues to glycine and with loops elongated by three and six glycine residues. For all the protein forms, denaturation/renaturation kinetic curves at different urea concentrations were obtained, folding/unfolding constants were calculated and dependencies of rate constant logarithms on urea concentrations were plotted. All the data gave an opportunity to calculate free energies of different apomyoglobin states. As a result, the mutations in apomyoglobin loops were demonstrated to have a real effect on intermediate state stability compared to unfolded state.
Rapid Alkalinization Factor (RALF) gene family genomic structure and transcriptional regulation during host-pathogen crosstalk in Fragaria vesca and Fragaria x ananassa strawberry
Authors: Negrini Francesca , O’Grady Kevin , Hyvönen Marko , Folta Kevin M. , Baraldi Elena 
Published: November 2019

AbstractRapid Alkalinization Factor (RALF) are cysteins-rich peptides ubiquitous in plant kingdom. They play multiple roles as hormone signals, starting from root elongation, cell growth, pollen tube development and fertilization. Their involvement in host-pathogen crosstalk as negative regulator of immunity in Arabidopsis has also been recognized. In addition, RALF peptides are secreted by different fungal pathogens as effectors during early stages of infections. Campbell and Turner previously identified nine RALF genes in F. vesca v1 genome. Here, based on the recent release of Fragaria x ananassa genome and F. vesca reannotation, we aimed to characterize the genomic organization of the RALF gene family in both type of strawberry species according to tissue specific expression and homology with Arabidopsis. We reveal the presence of 13 RALF genes in F. vesca and 50 in Fragaria x ananassa, showing a non-homogenous localization of genes among the different Fragaria x ananassa subgenomes associated with their different TE element contents and genome remodeling during evolution. Fragaria x ananassa RALF genes expression inducibility upon infection with C. acutatum or B. cinerea was assessed and showed that, among fruit expressed RALF genes, FaRALF3-1 was the only one upregulated after fungal infection. In silico analysis and motif frequency analysis of the putative regulatory elements upstream of the FaRALF3 gene was carried out in order to identify distinct pathogen inducible elements. Agroinfiltration of strawberry fruit with 5’ deletion constructs of the FaRALF3-1 promoter identified a region required for FaRALF3 expression in fruit, but did not identify a region responsible for fungal induced expression.
Perceived value of social media in students’ participation in social movement
Authors: Akter Shohana , Islam Md. Anwarul 
Published: November 2019

Purpose
The purpose of this study is to empirically investigate the use of social media (SM) and its influence for increasing students’ participation in the quota reform movement at the University of Dhaka, Bangladesh.

Design/methodology/approach
The revised technology acceptance model (TAM) was used to formulate this research’s hypotheses. A survey was administered to obtain data about students’ intention to use SM. The survey consisted of a set of questions based upon the revised TAM model. A total of 498 surveys were distributed and 304 students responded to it; hence, response rate was of 61.04%. A regression and single way ANOVA were conducted to test the hypotheses.

Findings
The results indicate that most of the students use SM for academic purposes and to get connected with friends. Among the social networking tools, Facebook is the most widely used by the respondents. Findings supported that perceived ease of use and perceived usefulness of SM affect student’s intention to increase participation in the quota reform movement. There were no significant relationships between gender and politics with the use of SM.

Research limitations/implications
A sample of students from Dhaka University was taken and the sample size was small. As a result, the findings of this study cannot be generalized in other settings. SM has a positive effect in the societies where change happens through collective actions.

Originality/value
Why and how students use SM has been widely discussed over the available literature, but students’ intention to use for it for social movements has not been studied. This study has made an effort to empirically examine the use of SM in the context of the quota reform movement in Bangladesh.
Harmonic form-finding for the design of doubly-curved shells
Authors: Brandt-Olsen Cecilie , Shepherd Paul , Richens Paul 
Published: November 2019

Purpose
Shell structures are highly efficient and are an elegant way of covering large uninterrupted spaces, but their complex geometry is notoriously difficult to model and analyse. This paper aims to describe a novel free-form shell modelling technique based on structural harmonics.

Design/methodology/approach
The method builds on work using weighted eigenmodes for three-dimensional mesh modelling in a computer graphics setting and extends it by specifically adapting the technique to an architectural design context. This not only enables the sculpting of free-form architectural surfaces using only a few control parameters but also takes advantage of the synergies between eigenmodes and structural buckling modes, to provide an efficient means of stiffening a shell against failure by buckling.

Findings
The result is a flexible free-form modelling tool that not only enables the creation of arbitrary doubly curved surfaces but also allows simultan. The tool helps to assist in the design of shells at the conceptual stage and encourages an interaction between the architect and engineer. A number of initiatives, including a single degree of freedom design, boundary constraints, visualisation aids and guidelines towards specific spatial configurations have been introduced to satisfactorily adapt the method to an architectural context.

Originality/value
The tool helps to assist in the design of shells at the conceptual stage and encourages an interaction between the architect and engineer. A number of initiatives, including a single degree of freedom design, boundary constraints, visualisation aids and guidelines towards specific spatial configurations have been introduced to satisfactorily adapt the method to an architectural context. This paper includes a full case study of the iconic British Museum Great Court Roof to demonstrate the applicability of the developed framework to real-world problems and the software developed to implement the method is available as an open-source download.
Bharatiya Yog Sansthan: reshaping society through Yog
Authors: Samal Jayalaxmi 
Published: November 2019

Learning outcomes
The learning outcomes are as follows: understand the operating model of a not-for-profit organization; gain knowledge about the significance of an organizational structure to successfully run a not-for-profit organization; learn the socio-cultural implication of yog through BYS; and learn the applicability of growth and business expansion strategy in the case of a not-for-profit organization.

Case overview/synopsis
This case covers the innovative operating model of Bharatiya Yog Sansthan (BYS) – a not-for-profit organization which offers free service towards the society through yog. BYS was a not-for-profit organization that survived for long without accepting donation in any form. They had more than 3,500 Yog Centers in 21 States and 2 union territories in India and more than 60 Yog Centers in foreign countries. They were the only not-for-profit organization which had operated such a huge number of Yog Centers across the world. Des Raj became the face of BYS after the demise of the founder Mr. Prakash Lal. While adhering to the core principle of the founder, the list of challenges in front of Mr. Des Raj and other yog enthusiasts’ associated with BYS was long. There arise no questions regarding the level of commitment and dedication of Des Raj and his team. They had left no stone unturned to bring BYS into the lime light and perhaps this is the reason because of which BYS had stood for more than fifty years. On one part they were strictly against commercialization and on the other part, they wanted to reach every household. Was it truly challenging for them to reach people without spending money on promotion? Was it really difficult for a not-for-profit which survived without donation to establish it as a brand?

Complexity academic level
This case can be taught effectively to MBA/ BBA students as a part of Strategic Management and Entrepreneurship subject.

Supplementary materials
Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 11: Strategy.
Melting heat transfer of a non-Newtonian phase change material in a cylindrical vertical-cavity partially filled porous media
Authors: Ghalambaz Mohammad , Ayoubi Ayoubloo Kasra , Hajjar Ahmad 
Published: November 2019

Purpose
This paper aims to investigate melting heat transfer of a non-Newtonian phase change material (PCM) in a cylindrical enclosure-space between two tubes using a deformed mesh method.

Design/methodology/approach
Metal foam porous layers support the inner and outer walls of the enclosure. The porous layers and clear space of the enclosure are filled with PCM. The natural convection effects during the phase change are taken into account, and the governing equations for the molten region and solid region of the enclosure are introduced. The governing equations are transformed into non-dimensional form and then solved using finite element method. The results are compared with the literary works and found in good agreement. The non-Newtonian effects on the phase change heat transfer and melting front are studied.

Findings
The results show that the increase of non-Newtonian effects (the decrease of the power-law index) enhances the heat melting process in the cavity at the moderate times of phase change heat transfer. The temperature gradients in porous metal foam over the hot wall are small, and hence, the porous layer notably increases the melting rate. When the melting front reaches the cold porous layer, strong non-linear behaviors of the melting front can be observed.

Originality/value
The phase change heat transfer of non-Newtonian fluid in a cylindrical enclosure partially filled with metal foams is addressed for the first time.
Lattice Boltzmann simulation for natural convection of supercritical CO2 in an inclined square cavity
Authors: Lu Shihua , Zhu Jianqi , Gao Dongyan , Chen Weiwei , Li Xinjun 
Published: November 2019

Purpose
This study aims to show the importance of natural convection of supercritical fluid in an inclined cavity. The heat transfer performance of natural convection can be improved.

Design/methodology/approach
A model of an inclined cavity was set up to simulate the natural convection of supercritical fluid. The influence of inclined angles (30 to approximately 90°) and pressures (8 to approximately 12 MPa) are analyzed. To ascertain flow and heat transfer of supercritical fluid natural convection, this paper conducts a numerical investigation using the lattice Boltzmann method (LBM), which is proven to be precise and convenient.

Findings
The results show that the higher heat transfer performance can be obtained with an inclined angle of 30°. It is also presented that the heat transfer performance under pressure of 10 MPa is the best. In addition, common criterion number correlations of average Nusselt number are also fitted.

Originality/value
These study results can provide a theoretical reference for the study of heat transfer of supercritical fluid natural convection in engineering.
Numerical investigation of thermal pulsating alumina/water nanofluid flow over three different cross-sectional channel
Authors: Hoseinzadeh S. , Otaghsara S.M. Taheri , Khatir M.H. Zakeri , Heyns P.S. 
Published: November 2019

Purpose
The purpose of this study is to investigate the pulsating flow in a three-dimensional channel. Channel flow is laminar and turbulent. After validation, the effect of different channel cross-sectional geometries (circular, hexagonal and triangular) with the pulsating flow are investigated. For this purpose, the alumina nanofluid was considered as a working fluid with different volume percentages (0 per cent [pure water], 3 per cent and 5 per cent).

Design/methodology/approach
In this study, the pulsatile flow was investigated in a three-dimensional channel. Channel flow is laminar and turbulent.

Findings
The results show that the fluid temperature decreases by increasing the volume percentage of particles of Al2O3; this is because of the fact that the input energy through the wall boundary is a constant value and indicates that with increasing the volume percentage, the fluid can save more energy at a constant temperature. And by adding Al2O3 nanofluid, thermal performance improves in channels, but it should be considered that the use of nanofluid causes a pressure drop in the channel.

Originality/value
Alumina/water nanofluid with the pulsating flow was investigated and compared in three different cross-sectional channel geometries (circular, hexagonal and triangular). The effect of different volume percentages (0 per cent [pure water], 3 per cent and 5 per cent) of Al2O3 nanofluid on temperature, velocity and pressure are studied.
Stock visibility for retail using an RFID robot
Authors: Morenza-Cinos Marc , Casamayor-Pujol Victor , Pous Rafael 
Published: November 2019

PurposeThe combination of the latest advancements in information and communication technologies with the latest developments in AutoID technologies, especially radio frequency identification (RFID), brings the possibility of high-resolution, item-level visibility of the entire supply chain. In the particular case of retail, visibility of both the stock count and item location in the shop floor is crucial not only for an effective management of the retail supply chain but also for physical retail stores to compete with online retailers. The purpose of this paper is to propose an autonomous robot that can perform stock-taking using RFID for item-level identification much more accurately and efficiently than the traditional method of using human operators with RFID handheld readers.Design/methodology/approachThis work follows the design science research methodology. The paper highlights a required improvement for an RFID inventory robot. The design hypothesis leads to a novel algorithm. Then the cycle of development and evaluation is iterated several times. Finally, conclusions are derived and a new basis for further development is provided.FindingsAn autonomous robot for stock-taking is proven feasible. By applying a proper navigation strategy, coupled to the stream of identifications, the accuracy, precision, consistency and time to complete stock-taking are significantly better than doing the same task manually.Research limitations/implicationsThe main limitation of this work is the unavailability of data to analyze the actual impact on the correction of inventory record inaccuracy and its subsequent implications for the supply chain management. Nonetheless, it is shown that figures of actual stock-tacking procedures can be significantly improved.Originality/valueThis paper discloses the potential of deploying an inventory robot in the supply chain. The robot is called to be a key source of inventory data conforming supply chain management 4.0 and omnichannel retail.