bluuebunny/crossref_metadata_2025_split huggingface dataset:
Socioeconomic status and health literacy as the important predictors of general health in Iran: A structural equation modeling approach
Authors: Nadi Taiebeh , Poorolajal Jalal , Doosti-Irani Amin 
Published: January 2020

Abstract
Background: We aimed to determine the level of health literacy (HL), and its association with general health. In addition, we investigated the direct and indirect association of socioeconomic status (SES) and general health among the adult population in Iran. Methods: This cross-sectional study involved 750 literate adults' people. The SES was assessed based on the owning of assets HL was evaluated using a validated questionnaire in Iran. General health was assessed using the WHO general health questionnaire. The simple and adjusted linear regression models, and structural equation modeling (SEM) were used for data analysis. Results: In adjusted model, female gender, higher level of education, use of books, pamphlets, or brochures as a source of health information, the higher level of SES was positively associated with higher HL. In addition, the HL was significantly associated with higher scores of general health. Results of SEM showed that the direct effect of SES on general health was not significant, but the indirect effect via HL was significant (path coefficient: 0.24; p<0.001). Conclusion: Results of our study indicated HL is strongly associated with general health among the adult population. SES had a significant indirect association with general health via the effect on health literacy.
Sex-specific Longitudinal Comparison of CES-D and PHQ-9 Depression Scales. A Concordance Analysis using data from the population-based Heinz Nixdorf Recall Study
Authors: Engel Miriam , Peternel Markus , Jöckel Karl-Heinz , Schramm Sara , Slomiany Uta , Moebus Susanne 
Published: January 2020

Abstract
Background To measure depressive symptoms in population-based studies, there are two well-established questionnaires: the Center for Epidemiologic Studies Depression Scale (CES-D) and the Patient Health Questionnaire-9 (PHQ-9). So far, comparisons between both instruments have only been performed using cross-sectional data, and in specific patient groups. Furthermore, comparisons for population-based studies are missing as well as sex-specific analyses. The aim is to evaluate the psychometric properties and concordance of the longitudinal results of CES-D and PHQ-9 in the German population-based Heinz Nixdorf Recall (HNR) study. Methods We used data of n=3,084 participants (48.8% men, mean age: 66.8 years). CES-D and PHQ-9 were assessed in the 8th (t8) and 9th (t9) annual postal follow up within two years via questionnaires. Depressive symptoms were defined as CES-D score ≥ 17 and PHQ-9 score ≥ 10. Internal consistency reliability, convergent validity, and agreement between PHQ-9 and CES-D were assessed using respectively Cronbach’s alpha, Pearson’s correlation, and Cohen’s kappa. To analyse depressive symptoms differences between t8 and t9 we used McNemar’s test. Sex-stratified results are presented. Results The prevalence of depressive symptoms at t8 was higher for CES-D (7.8%) than for PHQ-9 (4.4%). The prevalence slightly increased for CES-D (8.1%), as well as for PHQ-9 to 4.5% at t9. Internal consistency of the PHQ-9 and CES-D was good at both times (Cronbach’s alpha: CES-D t8 & t9: 0.89, PHQ-9 t8: 0.84; t9: 0.85). Cohen’s kappa of agreement between CES-D and PHQ-9 was moderate at both time points (t8: k=0.57; 95% CI: 0.51, 0.63; t9; k=0.58; 95% CI: 0.52, 0.64). For both instruments, the McNemar’s test revealed no differences in the proportion of depressives between t8 and t9. We could not observe sex-specific differences of psychometric characteristics, whereas the agreement between the CES-D and PHQ-9 performed slightly higher in men than in women (t8: k=0.61, resp. k=0.55). Conclusions The results do not support the superiority of one of the scales. Both scales perform well in this population-based cohort in both sexes and longitudinal approach. The decision, which scale to use may depend on characteristics other than the accuracy of the scale, including feasibility and clinical usability.
Research on Multi - Resonant LCL Harmonic Suppression Strategy
Authors: Chen Jingwen , Zhou Xin , Dang Hongshe 
Published: January 2020

Abstract
Aiming at the resonance problem in the process of grid connection of LCL filter microgrid inverter, a multi-resonance LCL harmonic suppression strategy is proposed. On the basis of analyzing the principle and establishing the mathematical model in detail, the realization process of the multi-resonance constant power compound control strategy is studied emphatically. Through the simulation, the validity of the control strategy is verified, The results show that the scheme stabilizes the output power and reduces the total harmonic distortion of the grid-connected inverter to 0.12%, and the corresponding phase current distortion rate drops to 0.02%.The suppression effect is obvious, it is an effective harmonic suppression method.
Analysis and Design of Image Segmentation Algorithm Based on Super-pixel and Graph Cut
Authors: Xiao Feng , Sun Hao 
Published: January 2020

Abstract
Image segmentation has always been a research hotspot in computer vision. Traditional image segmentation is based on pixels, and it is difficult to achieve the desired target effect. The manual segmentation method is too cumbersome and has limited precision. There is a certain degree of instability in the selection of interactively segmented pixels, which will affect the final segmentation results to a large extent.
In this paper, the superpixel block generated by the SLIC algorithm is used to preprocess the image, and then based on the Graph cut algorithm, the selection of seed points is improved, and the pixels of the background area are attempted to be optimized to obtain a more excellent target point sample. On top of the image segmentation, the foreground object is further divided with a frame, the pixels in the background are optimized, and the advantages of other segmentation algorithms are extracted to achieve the goal of global optimization, and interactive image segmentation is achieved.
Numerical simulation of scour and flow field over movable bed induced by a submerged wall jet
Authors: Samma Hamidreza , Khosrojerdi Amir , Rostam-Abadi Masoumeh , Mehraein Mojtaba , Cataño-Lopera Yovanni 
Published: January 2020

Abstract
Dam construction continues its rapid expansion around the world primarily for the purpose of hydropower generation. One important consequence of such projects is local scour at the downstream of the dam caused by outflow of excess reservoir water through spillways or bottom outlets that is associated with high velocities. The scour development endangers the dam foundation and river banks and undermines the stability of the hydraulic structures. In this study, a detailed three-dimensional (3D) flow simulation is conducted to investigate the complex fluid–sediment interactions leading to the formation of the scour hole and ridge systems downstream of a near-bottom jet. Three different bed-load equations, including Meyer-Peter–Müller, Nielsen, and Van Rijn formulas, are applied for calculating the bed-load transport rate. Comparison with a series of available experimental data shows that the Meyer-Peter–Müller equation results in better predictions than the two other relations. The performance of different turbulence models to reproduce vertical profiles of velocity and scour characteristic against the experimental data were evaluated. The vertical and horizontal profiles of the scour hole-ridge system are also compared with the corresponding experimental ones. The numerical model satisfactorily reproduces the geometric parameters representing the scour hole. However, the model overestimates the length of the scour hole.
Developing a sustainable biosolids program through a comprehensive, collaborative approach for Arlington county
Authors: Tsang K. Richard , Strawn Mary , Broderick Tom , Treadway Jonathan 
Published: January 2020

Abstract
Arlington County, Virginia has recently completed a wastewater solids master plan addressing the near- and long- term needs of the County's biosolids program. The planning process included comprehensive evaluation of over 70 technologies. The project team included representatives from engineering, operations, maintenance, and management from the County; a consultant team of national and local experts; a technical expert advisory committee from consultants, utilities, and academia; and community stakeholders. There were multiple project team workshops and regular presentations to stakeholders, feedback from which was incorporated into the planning process. Ultimately, there was a detailed evaluation of four process options – lime-stabilization (the current process), mesophilic anaerobic digestion, thermal hydrolysis pre-treatment leading to anaerobic digestion, and anaerobic digestion with thermal drying. The four options were evaluated against nineteen criteria representing economic, operating, environmental, and social issues of the ‘quadruple bottom line.’ The County has now developed a more sustainable biosolids program plan that includes the development of anaerobic digestion with thermal hydrolysis pre-treatment to produce a commercially viable biosolids product. The process will also produce biogas for use as fuel. The collaborative approach, which included evaluating numerous options and engaging with many stakeholders, contributed to the project's success and has provided a resilient roadmap towards a more sustainable biosolids program.
Exciting Potential of Nanoparticlized Lipidic System for Effective Treatment of Breast Cancer and Clinical Updates: A Translational Prospective
Authors: Harwansh Ranjit K. , Bahadur Shiv , Deshmukh Rohitas , Rahman Md. A. 
Published: January 2020

:
Breast cancer (BC) is a multifactorial disease and becoming a major health issue in women throughout
the globe. BC is a malignant type of cancer which results from transcriptional changes in proteins and genes.
Besides the availability of modern medicines and detection tools, BC has become a topmost deadly disease and its
cure still remains challenging. Nanotechnology based approaches are being employed for the diagnosis and
treatment of BC at clinical stages. Nanosystems have a significant role in the study of the interaction of malignant
cells with their microenvironment through receptor-based targeted approach. Nowadays, lipid-based nanocarriers
are being popularized in the domain of pharmaceutical and medical biology for cancer therapy. Lipidic nanoparticlized
systems (LNPs) have proven to have high loading efficiency, less toxicity, improved therapeutic efficacy,
enhanced bioavailability and stability of the bioactive compounds compared to traditional drug delivery systems.
In the present context, several LNPs based formulations have been undertaken in various phases of clinical trials
in different countries. This review highlights the importance of chemotherapeutics based lipidic nanocarriers and
their anticipated use for the treatment of BC. Furthermore, the clinical trials and future prospective of LNPs have
been widely elaborated.
Synthesis, Cytotoxicity and Docking Simulation of Novel Annulated Dihydroisoquinoline Heterocycles
Authors: Saleh Fatma M. , Hassaneen Hamdi M. , Mohamed Magda F. , Mohamed Yasmin Sh. 
Published: January 2020

Objective:
Coupling of ethyl 2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)acetate 2 with
diazotized anilines in ethanol in the presence of sodium acetate yielded 2-(2-arylhydrazono)-2-(6,7-
dimethoxy-3,4-dihydroisoquinolin-1-yl)acetate (4a-f).

Methods:
Treatment of 2 with α-bromoketones 6a-f in dry benzene at reflux gave the corresponding
isoquinolinium bromides 7a-f. Refluxing of each of the salts 7a-f in dry benzene and in the presence of
triethylamine yielded 2-arylpyrrolo-[2,1-a]isoquinoline structures 8a-f, that converted to ethyl (E)-8,9-
dimethoxy-3-(phenyldiazen-yl)-2-(aryl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-1-carboxylate (9a-f)
upon treatment with diazotized anilines 3 in ethanol in the presence of sodium acetate.

Results and Conclusion:
Cytotoxic assay was performed for in vitro antitumor screening against caucasian
breast adenocarcinoma (MCF7), hepatocellular carcinoma (HepG2) and colorectal carcinoma
(HCT-116) cell lines. The results were compared with the standard anticancer drug (doxorubicin). Molecular
docking using MOE 2014.09 software was carried out for the most potent compound 4d, which
showed the highest binding affinity towards the four tested proteins and thus initiated apoptosis of cancer
cells.
Neuroserpin in Bipolar Disorder
Authors: Çinar Rugül Köse 
Published: January 2020

Objective:
Neuroserpin is a serine protease inhibitor predominantly expressed in the nervous
system functioning mainly in neuronal migration and axonal growth. Neuroprotective effects of neuroserpin
were shown in animal models of stroke, brain, and spinal cord injury. Postmortem studies confirmed
the involvement of neuroserpin in Alzheimer’s disease. Since altered adult neurogenesis was postulated
as an aetiological mechanism for bipolar disorder, the possible effect of neuroserpin gene expression
in the disorder was evaluated.

Methods:
Neuroserpin mRNA expression levels were examined in the peripheral blood of bipolar disorder
type I manic and euthymic patients and healthy controls using the polymerase chain reaction
method. The sample comprised of 60 physically healthy, middle-aged men as participants who had no
substance use disorder.

Results:
The gene expression levels of neuroserpin were found lower in the bipolar disorder patients
than the healthy controls (p=0.000). The neuroserpin levels did not differ between mania and euthymia
(both 96% down-regulated compared to the controls).

Conclusion:
Since we detected differences between the patients and the controls, not the disease states,
the dysregulation in the neuroserpin gene could be interpreted as a result of the disease itself.
Antenatal Depression; its Prevalence of Positive Screen and the Associating Risk Factors Including Labor and Neonatal Outcome
Authors: Elias Nurezwana , Sulaiman Sofiah 
Published: January 2020

Background:
Antenatal depression is often neglected and unrecognized. It is known to
be associated with various unwanted outcomes for both mothers and babies.

Objective:
This study aims to assess the prevalence of a positive screen for antenatal depression and
its risk factors as well as the labour and neonatal outcomes.

Method:
265 pregnant women who received care from University Malaya Medical Centre were
recruited in this study. They completed the Edinburgh Postnatal Depression Scale (EPDS) questionnaires
twice; once during the antenatal period and once again during the postnatal period. Only
235 out of 265 data were analysed for the association between risk factors, labour and neonatal
outcome. Postnatal data that were collected after 4-6 weeks of delivery were completed in 90
women.

Results:
41 women (17%) were found to have a positive screen and it has a significant positive
correlation with postnatal EDPS score (r=0.919, p=0.00). After adjustment for confounders, preexisting
medical illness is the only risk factor found to be associated with the positive screen group
(OR 3.0, 95% CI1.11-8.46). The positive screen group is also associated with reduced neonatal
birth weight (0R=0.998; 95%CI0.997-0.999), reduced cord pH (OR=0.000; 95%CI0.000-0.202) and
increased blood loss at birth (0R=1.005; 95%CI1.001-1.009).

Conclusions:
The positive screen group of antenatal depression is associated with few adverse pregnancy
and neonatal outcomes. Therefore, a formal mental health assessment should be offered to all
pregnant women who are found to have a positive screen of antenatal depression.
Design, Synthesis, Docking and Biological Evaluation of Novel 4-hydroxy Coumarin Derivatives
Authors: Ramalakshmi N. , Chitra S.R. , Manimegalai P. , Arunkumar S. 
Published: January 2020

Background:
Hospital acquired (HA) infections are caused due to E. coliwhich is resistant to multiple drugs particularly to fluroquinolone class of drugs. Urinary tract infections (UTI) affects people in the community and in hospitals. 150 million people per annum are suffering from UTI worldwide.

Methods:
: In this present study, we designed 36 novel coumarin derivatives, also we predicted
pharmacokinetic and toxicity parameters. Docking studies were also carried out and all the compounds
were evaluated for antibacterial activity against resistant quinolone E. coli strain ATCC
25922. It was interesting to note that the introduction of electron-withdrawing group on the aromatic
ring resulted in compounds with an increased antibacterial activity, which is observed in
compound 6 (with 4-nitro substitution), compound 23 (chloro) and compound 30 (chloro, nitro).

Results:
From the MIC results, it was observed that compounds 6, 23 and 30 showed higher activity
with 0.5μg/ml, 0. 12 μg/ml, 0.5 μg/ml respectively. Docking studies were performed with the
active site of DNA gyrase (PDB ID: 4CKK). The maximum binding energy was found to be -10.7
Kcal/mol.

Conclusion:
From the study, it was found that 3 compounds were potentially active against quinolone-
resistant E. coli strains. This study can further be extended for in vivo evaluation.
Current Nanotechnology Based Solutions for Sustainable Wastewater Treatment
Authors: Murshid Shabnam , Gopinath Kannappan Panchamoorthy , Prakash Dhakshinamoorthy Gnana 
Published: January 2020

Background:
Industrialization plays an important role in the growth of a nation. But it is
also one of the causes of the deteriorating condition of our ecosystem. The pollution, be it aquatic,
terrestrial, or air-borne, has affected our environment drastically, and industrial and domestic
wastewater plays a major role in it. As the Earth transforms into urban sprawl, industries flourish,
pollution increases and the natural resources deplete. Recently nano-engineering based technologies
have been explored for the purpose of wastewater treatment, which helps in the detection and
remediation of the pollutants present in wastewater. Various nano-material based technologies
deployed in wastewater treatment are discussed in this article.

Methods:
A thorough survey of the literature was effectuated, and the study was focused mainly on
the different types of nanomaterials applied for the purpose of wastewater management and the
diverse treatment methods related to them. Literature was also studied to confirm the
functionalization of nanomaterials as pollution sensors.

Results:
There are four main kinds of nano-materials employed for the purpose of wastewater
remediation, i.e. metallic nanomaterials, carbon-based nanomaterials, nanocomposites, and
dendrimers. The treatment technologies utilizing these materials include nanofiltration, nanoadsorption,
nano-photocatalysis, and disinfection.

Conclusion:
Nanomaterials are quite efficient in removing pollutants from different kinds of
wastewater. But drawbacks such as expenditure and effect of the materials in the environment make
it difficult for real-time utilization. Since the nano-scaled elements behave differently than their
standard-sized counterparts, the consequence of these materials in the human life cycle is unknown.
This knowledge gap should be filled so that these materials can be adopted worldwide.
Synthesis, Biological and Computational Evaluation of Novel 2,3-dihydro-2-aryl-4-(4- isobutylphenyl)-1,5-benzothiazepine Derivatives as Anticancer and Anti-EGFR Tyrosine Kinase Agents
Authors: Shaik Afzal B. , Prasad Yejella R. , Nissankararao Srinath , Shahanaaz Shaik 
Published: January 2020

Background:
Despite the availability of a variety of chemotherapeutic agents, cancer is still one of
the leading causes of death worldwide because of the problems with existing chemotherapeutic agents like objectionable
side effects, lack of selectivity, and resistance. Hence, there is an urgent need for the development of
novel anticancer agents with high usefulness, fewer side effects, devoid of resistance and superior selectivity.

Objective:
The objective of this study is to synthesize a series of novel 1,5-benzothiazepine derivatives and
evaluate their anticancer activity employing biological and computational methods.

Methods:
Twenty new benzothiazepines (BT1-BT20) were prepared by condensing different 1-(4-
isobutylphenyl)ethanone chalcones with 2-amiothiophenol and evaluated for their anticancer activity by MTT
assay against three cell lines including HT-29 (colon cancer), MCF-7 (breast cancer) and DU-145 (prostate
cancer). These compounds were also tested for their inhibitory action against EGFR (Epidermal Growth Factor
Receptor) tyrosine kinase enzyme by taking into account of their excellent action against colon and breast cancer
cell lines. Further, the structural features responsible for the activity were identified by Pharmacophorebased
modelling using Schrodinger’s PHASETM software.

Results:
Among the 20 benzothiazepine derivatives, three compounds viz., BT18, BT19 and BT20 exhibited promising
activity against the cell lines tested and the activity of BT20 was more than the standard methotrexate. Again the
above three compounds showed excellent inhibitory activity with the percentage inhibition of 64.5, 57.3 and
55.8 respectively against EGFR (Epidermal Growth Factor Receptor) tyrosine kinase. PHASE identified a five-point
AHHRR model for the proposed activity and the computational studies provided insights into the structural
requirements for the anticancer activity and the results were consistent with the observed in vitro activity data.

Conclusion:
These novel benzothiazepines will be useful as lead molecules for the further development of new
cancer therapies against colon and breast cancers.
PSİKOLOJİK DANIŞMAN ADAYLARININ MESLEĞE İLİŞKİN KİŞİSEL EĞİLİMLERİ
Authors: Korkut Owen Fidan , Tuzgöl Dost Meliha 
Published: January 2020

Bu çalışmanın amacı lisans düzeyindeki
psikolojik danışman adaylarının cinsiyetlerine, sınıflarına, psikolojik danışma
eğitimini seçme nedenlerine ve alanının neden önemli olduğuna yönelik
görüşlerine göre mesleğe ilişkin kişisel eğilimlerinin değişip değişmediğini
ortaya koymaktır. Çalışmanın katılımcıları İç Anadolu Bölgesi’ndeki büyük bir
şehirde bulunan iki devlet üniversitesindeki toplam 431 Psikolojik Danışma ve
Rehberlik programı öğrencisidir. Veriler Mesleğe İlişkin Kişisel Eğilimleri
Değerlendirme Ölçeği ve Kişisel Bilgi Formu ile toplanmıştır. Elde edilen
bulgulara göre, kadın psikolojik danışman adaylarının ölçeğin toplam ve tüm altı alt boyutlardan elde
ettikleri puanların erkek psikolojik danışman adaylarına göre daha yüksek
olduğu görülmektedir. Sınıf düzeyi psikolojik danışman adaylarının kişilerarası
ilişkilere özen ve kendinin farkında olma alt boyutlarından elde ettikleri
puanların arttığı saptanmıştır. Psikolojik danışma alanını planlayarak
seçenlerin mesleğe ilişkin kişisel eğilimlerinin diğer nedenlerle seçenlere
göre daha yüksek olduğu elde edilen bulgulardandır. Benzer biçimde psikolojik
danışma alanını başkalarına yardımcı olduğu için önemli bulanların mesleğe
ilişkin kişisel eğilimleri de diğer görüşlerde olan gruplara göre daha yüksek
bulunmuştur. Bulgular alanyazın ışığında tartışılmış ve gelecek araştırmalar ve
uygulamalar için öneriler sunulmuştur.