bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive and comparative exploration of the Atp7b−/− mouse plasma proteome
Authors: Lacombe Maud , Jaquinod Michel , Belmudes Lucid , Couté Yohann , Ramus Claire , Combes Florence , Burger Thomas , Mintz Elisabeth , Barthelon Justine , Leroy Vincent , Poujois Aurélia , Lachaux Alain , Woimant France , Brun Virginie 
Published: December 2019

Abstract
Wilson's disease (WD), a rare genetic disease caused by mutations in the ATP7B gene, is associated with altered expression and/or function of the copper-transporting ATP7B protein, leading to massive toxic accumulation of copper in the liver and brain. The Atp7b−/− mouse, a genetic and phenotypic model of WD, was developed to provide new insights into the pathogenic mechanisms of WD. Many plasma proteins are secreted by the liver, and impairment of liver function can trigger changes to the plasma proteome. High standard proteomics workflows can identify such changes. Here, we explored the plasma proteome of the Atp7b−/− mouse using a mass spectrometry (MS)-based proteomics workflow combining unbiased discovery analysis followed by targeted quantification. Among the 367 unique plasma proteins identified, 7 proteins were confirmed as differentially abundant between Atp7b−/− mice and wild-type littermates, and were directly linked to WD pathophysiology (regeneration of liver parenchyma, plasma iron depletion, etc.). We then adapted our targeted proteomics assay to quantify human orthologues of these proteins in plasma from copper-chelator-treated WD patients. The plasma proteome changes observed in the Atp7b−/− mouse were not confirmed in these samples, except for alpha-1 antichymotrypsin, levels of which were decreased in WD patients compared to healthy individuals. Plasma ceruloplasmin was investigated in both the Atp7b−/− mouse model and human patients; it was significantly decreased in the human form of WD only. In conclusion, MS-based proteomics is a method of choice to identify proteome changes in murine models of disrupted metal homeostasis, and allows their validation in human cohorts.
Ergocalciferol improves endothelial vasodilatory and vasoconstrictor function in an in vivo model of mild uraemia
Authors: Dreyer Gavin , Kieswich Julius , Harwood Steven , Ahluwalia Amrita , Yaqoob Muhammad M. 
Published: December 2019

Abstract
Endothelial dysfunction and vitamin D deficiency are prevalent in patients with cardiovascular disease (CVD) and chronic kidney disease (CKD). Both are risk factors for cardiovascular events in patients with CKD. No studies have investigated the effect of nutritional forms of vitamin D on endothelial function in earlier stages of CKD, when vascular endothelium may be more amenable to this therapy. We studied the effect of ergocalciferol in a pre-clinical model of mild uraemia.
Male Wistar rats underwent either a 5/6th nephrectomy or sham surgery. Four weeks after the final stage of the surgery, these two groups were randomly allocated to placebo or an oral dose of 1000 iu of ergocalcfierol at day 7 and 2 pre sacrifice. Vascular responses to acetylcholine, Spermine NONOate and phenylephrine were determined in aortic rings. Blood pressure, calcium, phosphate and parathyroid hormone were measured in all groups.
Ergocalciferol significantly improved the endothelium-dependent responses to acetylcholine and overcame the blunting of the contractile response to phenylephrine seen in uraemic animals. Ergocalciferol improved the contractile response to potassium chloride in uraemic, but not sham animals. All effects occurred independently of changes to calcium, phosphate, parathyroid hormone and systolic blood pressure. There were no differences in endothelium-independent relaxation to Spermine NONOate.
In summary, in a model of mild uraemia, ergocalciferol improved vasodilator and vasoconstrictor tone independently of blood pressure and bone mineral parameters suggesting a direct effect of ergocalciferol on the endothelium.
miR-126a-3p induces proliferation, migration and invasion of trophoblast cells in pre-eclampsia-like rats by inhibiting A Disintegrin and Metalloprotease 9
Authors: Zhao Shenglong , Wang Jiandong , Cao Zheng , Gao Lei , Zheng Yuanyuan , Wang Jing , Liu Xiaowei 
Published: December 2019

Abstract
The present study aimed to investigate the underlying mechanism of miR-126a-3p in the proliferation, migration and invasion of trophoblast cells in pre-eclampsia-like rats by targeting A Disintegrin and Metalloprotease 9 (ADAM9). First, the interaction between miR-126a-3p and ADAM9 was confirmed via biochemical assays. Placental tissues and trophoblast cells were then obtained. RNA in situ hybridization was performed in order to detect miR-126a-3p expression in the placenta. Subsequently, a series of biological assays, including reverse transcription-quantitative PCR (RT-qPCR), Western blotting, MTT assay, apoptosis assay, cell cycle assay, wound healing assay and transwell assay were adopted in order to determine the cell proliferation, cell cycle distribution, apoptotic rate, and migration and invasion of trophoblast cells in each group. The results revealed that miR-126a-3p was down-regulated in the placenta of pre-eclampsia-like rats. In vivo experiments’ results indicated that miR-126a-3p could inhibit ADAM9 expression, and induce cyclin D1, Matrix metalloproteinase (MMP) 2 (MMP-2), MMP-9 expression. MTT, apoptosis and cell cycle assay results revealed that trophoblast cells transfected with miR-126a-3p mimic or si-ADAM9 exhibited higher proliferative activity and a lower apoptotic rate compared with the blank group (all P&lt;0.05). The wound healing assay and transwell assay results confirmed that, compared with the blank group, the migration and invasion ability of trophoblast cells in the miR-126a-3p mimic group and small interfering RNA (siRNA)-ADAM9 group were significantly increased (all P&lt;0.05). Conversely, miR-126a-3p inhibitor treatment revealed the opposite effect (all P&lt;0.05). In conclusion, the present study demonstrated that miR-126a-3p could enhance proliferation, migration and invasion, but decrease the apoptosis rate of trophoblast cells in pre-eclampsia-like rats through targeting ADAM9.
Calibration method for attenuator piece used in calibrating a transmittance visibility meter
Authors: Liang Jing , Zhang Guoyu , Zhang Jian , Xu Da , Sun Gaofei 
Published: December 2019

Aiming at the method of indoor calibration of a transmission visibility meter has not been established; a new calibration method by measuring the luminous transmittance of attenuator piece was established. Based on the high homogeneity stability lighting and the multi‐spectral transmittance analysis technique, a calibration system of the transmission visibility meter by measuring the luminous transmittance of the attenuator piece was designed. The experiment was designed by measuring the luminous transmittance with the range of 0.2–99.2% of a series of calibrated attenuators and the visibility in the range of 40 m to 20 km, then the luminous transmittance errors, the meteorological optical range (MOR) errors and their uncertainty were obtained. The result showed that the luminous transmission error was within ±0.18%, which satisfied the calibration requirement for transmission visibility meter transmittance; the MOR calibration error met the accuracy requirements of the International Civil Aviation Organisation for visibility measurement; this work will have guiding significance in establishing a calibration procedure for the transmission visibility meter.
Fourier series for eclipses on exoplanet binaries
Authors: Visser P. M. , Mol M. A. 
Published: December 2019

Context. A double planet system or planet binary undergoes eclipses that modify the reflective light curve. In the time domain, the eclipse events are fast and weak. This would make their signal difficult to find and recognize in the phase light curve, even for small inclinations when eclipses happen frequently. However, due to the quasiperiodic nature of the phenomenon, the Fourier transform of the direct reflection signal consists of a double sum of sharp peaks. These peaks can be resolved for large close binaries and sufficiently long observation times with a star coronagraph.
Aims. Eclipses modulate the phase curve, having an orbital period 2π∕ω, with a contribution from the relative motion in the binary plane of a period 2π∕Ω. This leads to a spectral structure with basis frequencies ω and Ω. We aim to characterize these spectra.
Methods. We studied the regime of short eclipses that occur when the planet radii are small compared to the planet separation. We derived formulas for the peak amplitudes applicable to homogeneous (Lambertian) planet binaries in circular orbit with small inclination.
Results. The effects of an eclipse and of double reflection appear as first- and second-order contributions (in planet radius over separation) in the reflection signal, respectively. Small peaks appear as observable side bands in the spectrum. Identical structures around mΩ are characteristic of short-duration eclipses. Deceasing side bands could indicate double reflection between companions.
Conclusions. Fourier analysis of the light curve of non-transiting planets can be used to find planets and their moons. Difficulties in interpreting the structures arise for small planet separation and when there are several moons in mean-motion resonance.
Jupiter formed as a pebble pile around the N2 ice line
Authors: Bosman A. D. , Cridland A. J. , Miguel Y. 
Published: December 2019

Context. The region around the H2O ice line, due to its higher surface density, seems to be the ideal location to form planets. The core of Jupiter, as well as the cores of close-in gas giants are therefore thought to form in this region of the disk. Nevertheless, constraining the formation location of individual planets has proven to be difficult.
Aims. We aim to use the nitrogen abundance in Jupiter, which is around four times solar, in combination with Juno constraints on the total mass of heavy elements in Jupiter to narrow down its formation scenario.
Methods. Different pathways of enrichment of the atmosphere of Jupiter are considered, such as the accretion of enriched gas, pebbles, and planetesimals, and their implications for the oxygen abundance of Jupiter are discussed.
Results. The super-solar nitrogen abundance in Jupiter necessitates the accretion of extra N2 from the proto-solar nebula. The only location of the disk where this can happen is outside or just inside the N2 ice line. These constraints favor a pebble accretion origin of Jupiter, from the perspective of composition and planet formation. We predict that Jupiter’s oxygen abundance is between 3.6 and 4.5 times solar.
Compression Garment-induced Leg Changes Increase Hemodynamic Responses in Healthy Individuals
Authors: Lee Daniel C. W. , Law Helen Ka Wai , Ali Ajmol , Sheridan Sinead E. , Wong Stephen H. S. , Lee Shara Wee Yee 
Published: December 2019

AbstractThis study evaluated the morphological changes of the lower limb and associated hemodynamic responses to different lower-body compression pressures (COMPs) in physically active, healthy individuals at rest. Each of the 32 participants underwent three trials with three different degrees of lower-body compression applied: “Low” (2.2±1.4 mmHg), “Medium” (12.9±3.9 mmHg), and “High” (28.8±8.3 mmHg). In each COMP, a cross-sectional area of leg muscles (CSAmuscle), subcutaneous fat (CSAfat), superficial vessels (SupV), deep arteries (DA), and deep veins (DV) at the calf, knee, and thigh levels were measured using magnetic resonance imaging (MRI). Additionally, blood pressure (BP), heart rate (HR), cardiac output (CO), stroke volume (SV), and systemic vascular resistance (SVR) were measured using Doppler ultrasound (USCOM®). With High COMP, calf CSAmuscle and SupV were smaller (p<0.01), whereas DA and DV were larger (p<0.05). Calf CSAfat, however, was similar among all COMPs. There were no major changes in CSAmuscle and CSAfat at knee and thigh levels. CO (3.2±0.9 L/min) and SV (51.9±16.4 mL) were higher (p<0.05) only with High COMP, but other hemodynamic variables showed no significant changes across different COMPs. The High COMP at the lower limb induces leg morphological changes and increases associated hemodynamic responses of physically active healthy individuals at rest.
Safety and efficacy of endoscopic submucosal dissection for rectal neoplasia: a multicenter North American experience
Authors: Yang Dennis , Aihara Hiroyuki , Perbtani Yaseen B. , Wang Andrew Y. , Aadam Abdul Aziz , Tomizawa Yutaka , Hwang Joo Ha , Zou Baiming , Natov Nikola S. , Siegel Amanda , Khoshknab Milad Pourmousavi , Khashab Mouen A. , Ngamruengphong Saowanee , Khara Harshit S. , Diehl David L. , Maniere Thibaut , Andrawes Sherif , Benias Petros , Kumta Nikhil A. , Ramay Fariha , Kim Raymond E. , Samarasena Jason , Chang Kenneth , Hashimoto Rintaro , Tharian Benjamin , Inamdar Sumant , Lan Gloria , Sethi Amrita , Nosler Michael J. , Tabash Abdalaziz , Othman Mohamed O. , Draganov Peter V. 
Published: December 2019

Abstract
Background and aims Rectal lesions traditionally represent the first lesions approached during endoscopic submucosal dissection (ESD) training in the West. We evaluated the safety and efficacy of rectal ESD in North America.
Methods This is a multicenter retrospective analysis of rectal ESD between January 2010 and September 2018 in 15 centers. End points included: rates of en bloc resection, R0 resection, adverse events, comparison of pre- and post-ESD histology, and factors associated with failed resection.
Results In total, 171 patients (median age 63 years; 56 % men) underwent rectal ESD (median size 43 mm). En bloc resection was achieved in 141 cases (82.5 %; 95 %CI 76.8–88.2), including 24 of 27 (88.9 %) with prior failed endoscopic mucosal resection (EMR). R0 resection rate was 74.9 % (95 %CI 68.4–81.4). Post-ESD bleeding and perforation occurred in 4 (2.3 %) and 7 (4.1 %), respectively. Covert submucosal invasive cancer (SMIC) was identified in 8.6 % of post-ESD specimens. There was one case (1/120; 0.8 %) of recurrence at a median follow-up of 31 weeks; IQR: 19–76 weeks). Older age and higher body mass index (BMI) were predictors of failed R0 resection, whereas submucosal fibrosis was associated with a higher likelihood of both failed en bloc and R0 resection.
Conclusion Rectal ESD in North America is safe and is associated with high en bloc and R0 resection rates. The presence of submucosal fibrosis was the main predictor of failed en bloc and R0 resection. ESD can be considered for select rectal lesions, and serves not only to establish a definitive tissue diagnosis but also to provide curative resection for lesions with covert advanced disease.
Echocardiographic Assessment of Left Ventricular Remodeling in American Style Footballers
Authors: Moneghetti Kegan James , Singh Tamanna , Hedman Kristofer , Christle Jeffrey W. , Kooreman Zoe , Kobayashi Yukari , Bouajila Sara , Amsallem Myriam , Wheeler Matthew , Gerche Andre La , Ashley Euan , Haddad Francois 
Published: December 2019

AbstractSeveral athletic programs incorporate echocardiography during pre-participation screening of American Style Football (ASF) players with great variability in reported echocardiographic values. Pre-participation screening was performed in National Collegiate Athletic Association Division I ASF players from 2008 to 2016 at the Division of Sports Cardiology. The echocardiographic protocol focused on left ventricular (LV) mass, mass-to-volume ratio, sphericity, ejection fraction, and longitudinal Lagrangian strain. LV mass was calculated using the area-length method in end-diastole and end-systole. A total of two hundred and thirty players were included (18±1 years, 57% were Caucasian, body mass index 29±4 kg/m2) after four players (2%) were excluded for pathological findings. Although there was no difference in indexed LV mass by race (Caucasian 78±11 vs. African American 81±10 g/m2, p=0.089) or sphericity (Caucasian 1.81±0.13 vs. African American 1.78±0.14, p=0.130), the mass-to-volume ratio was higher in African Americans (0.91±0.09 vs. 0.83±0.08, p<0.001). No race-specific differences were noted in LV longitudinal Lagrangian strain. Player position appeared to have a limited role in defining LV remodeling. In conclusion, significant echocardiographic differences were observed in mass-to-volume ratio between African American and Caucasian players. These demographics should be considered as part of pre-participation screening.
Interventional Cryoneurolysis: What Is the Same, What Is Different, What Is New?
Authors: Bittman Ross W. , Behbahani Keywan , Gonzalez Felix , Prologo J. David 
Published: December 2019

AbstractCryoneurolysis is the deliberate application of cold temperatures to nerves for therapeutic purposes. The idea of treating pain with this technique is thousands of years old and has evolved over time through the application of surgical techniques, nerve stimulation and/or landmark guidance, and through device development. Recent integration of the interventional radiology skill set to this space has unlocked a myriad of opportunities—primarily through a unique ability to percutaneously access deep structures in the body with accuracy and precision, and the capacity to monitor ablation zones. Understanding of the specific neurohistological process that follows targeted cryoneurolysis leads to new options for treating patients in pain without drugs and opens doors for the potential modification of a wide array of disease states.
The effect of traditional bullying-victimization on behaviour cyberbullying among college students: Based on the structural equation mode / El efecto de la victimización por acoso tradicional en las conductas de ciberacoso entre estudiantes universitarios: un estudio basado en el modelo de ecuaciones estructurales
Authors: Dong Yinghong 
Published: December 2019

The study aimed to establish an explanatory model for the effect of traditional bullying victimization on cyberbullying behaviour. The sample was composed of 354 college students (50% male and female) aged 17 to 24 ( M = 19.54, SD = 1.21) enrolled in three universities in Shandong province, China. They were investigated using the questionnaires of Bullied Scale, Moral Disengagement Scale, Perceived Anonymity Scale and Cyberbullying scale. Structural equation model was conducted to identify the effect of traditional bully-victimization on cyberbullying behaviour and the mediating role of moral disengagement, as well as the moderating role of perceived anonymity of cyberspace. In this sample, traditional bully victimization may lead the college students to engage in cyberbullying behaviour positively. Moral disengagement was the mediator between traditional bully victimization and cyberbullying behaviour. The perceived anonymity of cyberspace was the moderator between traditional bully victimization and cyberbullying behaviour. College students who were victims of traditional bullying showed a higher tendency of becoming cyberbullying assaulters via the partial influence of moral disengagement, and the effect was magnified by the perceived anonymity of cyberspace.
Development of portable solar storage device
Authors: Roslan M S , Adan F , Mohammad M A , Norazman N , Haizam S , Haider Z 
Published: December 2019

Abstract
The demanding for energy in Malaysia to use for all-purpose of small device charging has been developed. The purpose of this project is to develop portable solar storage (PSS) device with all the components of an off-grid solar station compact into a small portable handheld casing. The PSS is aimed for outdoor activity passionate such as hikers, campers and climbers that need a portable power charger that can charge their electronic gadgets while they carry on with their activities. The input current and voltage of the solar panel had been recorded over a span of two weeks. The generation of electricity is harvested from solar irradiation on 12 V and 18 V solar panel and stored upon 98 W energy storage beneath the solar panel. The power stored put on the test and capable to recharge up to 10,000 mAh capacity for one-time charging. As a comparison between 12V and 18 V solar panel, the result shows the average charging rate of the 12 V and 18 V solar panels could reach as high as 16.086 W/h and 13.35 W/h respectively which considered had reached 12.75% efficiency.
Optimization of ZnO nanorods growth duration for humidity sensing application
Authors: Hafiz Jali Mohd , Rafis Abdul Rahim Hazli , Helmi Mohd Yusof Haziezol , Md Johari Md Ashadi , Thokchom Siddharth , Wadi Harun Sulaiman 
Published: December 2019

Abstract
This paper described an optimization approach of ZnO nanorods growth duration based on humidity sensing scheme. The proposed structure comprises of silica microfiber integrated with Zinc Oxide (ZnO) nanorods coated glass surface. The silica microfiber was tapered into constant waist diameter of 10 µm using flame brushing technique. The glass surface was grown with ZnO nanorods using hydrothermal method for 6 hours, 9 hours, 12 hours, 15 hours and 18 hours growth time. ZnO nanorods growth time would affect morphological structures such as density which change the light absorption into the nanorods. Samples were exposed to the difference humidity level ranging from 35%RH to 85%RH to observe the change of ZnO refractive index on the glass surface resulting different light attenuation in the silica microfiber. It utilizes the unique features of the scattering and surface absorption capability of the microfiber and ZnO nanomaterials coated glass surface to alter the output light intensity. The reported results may contribute to the optimal ZnO nanorods growth time for humidity sensing application.
Q-switched in figure of 8 by using graphite flakes as saturable absorber
Authors: Alsaady Mofaq , Awang NA , Zaker Thoalfiqar A 
Published: December 2019

Abstract
In this study, a successful experiment has been reported on pulse compression in the Q-switched fiber laser by utilizing graphite flakes as a saturable absorber (SA). The sputter deposition method was used to deposited graphite flakes as SA, incorporated into the bore of the laser in order to compress the width of the pulse in the operation of Q-switching. The small repetition rate at 29.6 kHz was mentioned as the maximum power of the pump with the single-to-noise ratio (SNR) ∼30dB was required to compress the pulse. Accordingly, graphite flakes have the ability to be utilized as an effective S A in producing pulse compression and Q-switching mode, that will be may fixedly lead to further enhancement in the fiber laser pulsed.
Low magnetic field effect of circular conductors on a fiberoptic transmission system
Authors: Mohammed Firas S , Zaker Thoalfiqar A , Abdaljalil Rana Oday , Alsaady Mofaq M B 
Published: December 2019

Abstract
In a communication system that uses fiber optics, light wave transmissions respond to the influence of surrounding magnetic fields, thereby causing undesirable changes in the output signal. Thus, an important task in electrical engineering is analyzing polarization and intensity changes to protect sensitive data transmission systems from unintended sources of magnetic disturbance. In this study, we propose a signal processing method to evaluate fiber-optic transmission systems under the influence of a weak magnetic field. This method is conducted by performing experimental and theoretical measurements on the axis of light propagation using a laboratory setup and simulation software OptiSystem (version 7.0). Results show that the shape, size, and axial positions of the conductor plays a key role in strengthening the magnetic field influence on increasing the bit error rate and decreasing the Q factor of the communication system.