bluuebunny/crossref_metadata_2025_split huggingface dataset:
<b>DESENHO DA INFORMAÇÃO NA PERSPECTIVA DA CIÊNCIA DA INFORMAÇÃO</b>
Authors: Ribeiro Nivaldo Calixto , Santos Sarah Rúbia de Oliveira 
Published: March 2020

A Ciência da Informação tem apresentado campos de estudo e modelos de compreensão variados. Assim, este trabalho tem como objetivo analisar o conceito de informação na perspectiva da Ciência da Informação. As contribuições teóricas dos autores Saracevic e Wood, Adkinson, Borko, Buckland e Rayward foram adotadas para trilhar a narrativa deste relato. A metodologia adotada é do tipo descritiva e bibliográfica, de abordagem dedutiva baseada em artigos científicos, relatórios técnicos, correspondências por e-mail, obituários, currículos entre outros documentos. Com relação ao conceito “informação”, criou-se um desenho de instrução sintetizado das visões e perspectivas dos autores citados sobre o termo em estudo.
Synthesis, Spectroscopic, In-vitro and Computational Analysis of Hydrazones as Potential Antituberculosis Agents: (Part-I)
Authors: Thorat Bapu R. , Rani Deepa , Yamgar Ramesh S. , Mali Suraj N. 
Published: March 2020

Background:
Since the last few decades, the healthcare sector is facing the problem of
the development of multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis
(XDR-TB) infections all over the world. Regardless of the current healthcare progress for the
treatment of mycobacterial infections, we are still unable to control addition of every year 9 million
new cases of tuberculosis (TB).

Objective:
We had an objective to synthesize some novel hydrazones, which were further subjected
to characterization, Photoluminescence study, in vitro anti-mycobacterium testing and in silico
ADMET predictions.

Methods:
Some new hydrazone derivatives have been successfully prepared by the condensation
reaction in the present study. All the compounds were characterized by using FTIR, NMR, UV,
Fluorescence spectroscopic techniques.

Results:
All our newly synthesized compounds showed strong electronic excitation at 292.6 –
319.0 nm and displayed more intense emissions in the 348 – 365 nm regions except compound 3i.
The newly synthesized hydrazones 3a, 3b, 3f and 3g were found to be the most active compounds
and showed MIC (Minimum inhibitory concentrations) values of 12.5 μg/mL.

Conclusion:
In the realm of development of more potent, effective, safer and less toxic
antituberculosis agents; our current study would definitely help the medicinal chemists to develop
potent analogues containing hydrazine motifs in them.
Preclinical and Clinical Studies on Bryostatins, A Class of Marine-Derived Protein Kinase C Modulators: A Mini-Review
Authors: Raghuvanshi Rinky , Bharate Sandip B. 
Published: March 2020

:Bryostatins are complex macrolactones isolated from marine organisms Bryozoan Bugula neritina. They are potent modulators of protein kinase C isozymes (PKCα: ki = 1.3-188 nM), and are one of the most extensively investigated marine natural products in clinical trials. Although ~21 natural bryostatins have been isolated, however only bryostatin-1 (1) has received much interest among medicinal chemists and clinicians. The structure-activity relationship of bryostatins has been well established, with the identification of key pharmacophoric features important for PKC modulation. The low natural abundance and the long synthetic route have prompted medicinal chemists to come-up with simplified analogs. Bryostatin skeleton comprises three pyran rings connected to each other to form a macrocyclic lactone. The simplest analog 27 contains only one pyran, which is also able to modulate the PKCα activity; however, the cyclic framework appears to be essential for the desired level of potency. Another simplified analog 17 ("picolog") exhibited potent and in-vivo efficacy against lymphoma. Bryostatin-1 (1) has shown an acceptable intravenous pharmacokinetic profile in mice and displayed promising in-vivo efficacy in mice models of various cancers and Alzheimer's disease. Bryostatin-1 was investigated in numerous Phase I/II oncology clinical trials; it has shown minimal effect as a single agent, however, provided encouraging results in combination with other chemotherapy agents. FDA has granted orphan drug status to bryostatin-1 in combination with paclitaxel for esophageal cancer. Bryostatin-1 has also received orphan drug status for fragile X syndrome. Bryostatin-1 was also investigated in clinical studies for Alzheimer's disease and HIV infection. In a nutshell, the natural as well as synthetic bryostatins have generated a strong hope to emerge as treatment for cancer along with many other diseases.
123I-FP-CIT Brain SPECT Findings in Succinic Semialdehyde Dehydrogenase (SSADH) Deficiency
Authors: Frantellizzi Viviana , Pontico Mariano , Pani Arianna , De Feo Maria Silvia , De Vincentis Giuseppe 
Published: March 2020

Background:
Succinic semialdehyde dehydrogenase (SSADH) deficiency is a rare autosomal
recessive disorder. Neuroimaging findings are commonly considered rather non-specific. To
date, no neuroreceptorial brain imaging with 123I-FP-CIT(DaTScan) is known in subjects with SSADH
deficiency.

Methods:
A 30-year-old man gained our attention to rule out any potential nigrostriatal dopaminergic
presynaptic pathway alterations in a clinical context of a γ-hydroxybutyric aciduria. He showed impossibility
to the autonomous gait, head and trunk retropulsion, lower limbs strength deficit, verbal and
upper limbs motor stereotypies and irregular eye tracking.

Results:
His brain MRI depicted basal ganglia signal abnormalities. Brain SPECT with DaTSCan images
showed a global significant reduction of radiotracer uptake.

Conclusions:
The findings obtained by means of the 123I-DaTScan brain SPECT may give rise to new
concerns on pathophysiological aspects of the SSADH deficiency disorder that has never been investigated
before, such as the nigrostriatal dopaminergic system’s functionality, encouraging further investigation.
Safety Awareness Attitudes among Malaysian Climbers
Authors: Zahir Amier Hazim , Abdul Latif Rozita , Nawi Nor Fadzlina , M.kes Siswantoyo 
Published: March 2020

Outdoor recreation gives different project benefits likes gear rental and outdoor exercises. Safety awareness is related to outdoor recreation activities such as climbing and hiking. The objective was divided into three aspects, the relationship between personality and responsible behavior, the relationship between personality and attitudes, and the relationship between safety awareness attitudes and responsible behavior among climbers. This study used a quantitative method that involved 378 climbers of four mountains in Malaysia. The finding indicated that responsible behavior influences personality and a personality influences attitude. It is showed that there was a significant relationship among the climbers.Keywords: safety awareness; personality; attitudes; responsible behavioreISSN: 2398-4287 © 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer-review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v5i13.2097
Механические свойства ультрамелкозернистого алюминия в области температур 4.2-300 K
Authors: Орлова Т.С. , Шпейзман В.В. , Мавлютов А.М. , Латынина Т.А. , Аверкин А.И. , Тимашов Р.Б. 
Published: March 2020

Abstract The tensile curves of ultrafine-grained (UFG) aluminum structured by high pressure torsion (HPT) technique have been obtained at 4.2 and 77 K for the first time as well as the temperature dependence of its yield strength in the range 4.2–300 K. The analysis of the results in correlation with microstructure parameters and comparison with the results of such studies for UFG aluminum structured by equal-channel angular pressing (ECAP) technique has been performed. It has been shown that the HPT-processed aluminum has a significantly higher yield strength at low temperatures than the ECAP-processed aluminum. Combination of high strength and plasticity (440 MPa and 55%, respectively) was obtained at 4.2 K, which makes this material attractive for practical use at low temperatures. The analysis of the obtained results indicates that, at room and low (77 K) temperatures, the plasticity of the UFG aluminum with a grain size less than 1 μm largely depends on the nature of the grain size distribution, as well as on the type and state of the grain boundaries (equilibrium or nonequilibrium), which opens up prospects for controlling the value of plasticity by creating a given microstructural design while maintaining a high level of strength of ultrafine-grained materials.
Long-Term Effectiveness and Cost-Effectiveness of Videoconference-Delivered Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder, Panic Disorder, and Social Anxiety Disorder in Japan: One-Year Follow-Up of a Single-Arm Trial
Authors: Matsumoto Kazuki , Hamatani Sayo , Nagai Kazue , Sutoh Chihiro , Nakagawa Akiko , Shimizu Eiji 
Published: March 2020

Background
Face-to-face individual cognitive behavioral therapy (CBT) and internet-based CBT (ICBT) without videoconferencing are known to have long-term effectiveness for obsessive-compulsive disorder (OCD), panic disorder (PD), and social anxiety disorder (SAD). However, videoconference-delivered CBT (VCBT) has not been investigated regarding its long-term effectiveness and cost-effectiveness.

Objective
The purpose of this study was to investigate the long-term effectiveness and cost-effectiveness of VCBT for patients with OCD, PD, or SAD in Japan via a 1-year follow-up to our previous 16-week single-arm study.

Methods
Written informed consent was obtained from 25 of 29 eligible patients with OCD, PD, and SAD who had completed VCBT in our clinical trial. Participants were assessed at baseline, end of treatment, and at the follow-up end points of 3, 6, and 12 months. Outcomes were the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Panic Disorder Severity Scale (PDSS), Liebowitz Social Anxiety Scale (LSAS), Patient Health Questionnaire–9 (PHQ-9), General Anxiety Disorder–7 (GAD-7), and EuroQol-5D-5L (EQ-5D-5L). To analyze long-term effectiveness, we used mixed-model analysis of variance. To analyze cost-effectiveness, we employed relevant public data and derived data on VCBT implementation costs from Japanese national health insurance data.

Results
Four males and 21 females with an average age of 35.1 (SD 8.6) years participated in the 1-year follow-up study. Principal diagnoses were OCD (n=10), PD (n=7), and SAD (n=8). The change at 12 months on the Y-BOCS was −4.1 (F1=4.45, P=.04), the change in PDSS was −4.4 (F1=6.83, P=.001), and the change in LSAS was −30.9 (F1=6.73, P=.01). The change in the PHQ-9 at 12 months was −2.7 (F1=7.72, P=.007), and the change in the GAD-7 was −3.0 (F1=7.09, P=.009). QALY at 12 months was 0.7469 (SE 0.0353, 95% Cl 0.6728-0.821), and the change was a significant increase of 0.0379 (P=.01). Total costs to provide the VCBT were ¥60,800 to ¥81,960 per patient. The set threshold was ¥189,500 ($1723, €1579, and £1354) calculated based on willingness to pay in Japan.

Conclusions
VCBT was a cost-effective way to effectively treat Japanese patients with OCD, PD, or SAD.

Trial Registration
University Hospital Medical Information Network Clinical Trials Registry UMIN000026609; https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000030495
A Randomized Trial Evaluating the Efficacy and Safety of Fast-Acting Insulin Aspart Compared With Insulin Aspart, Both in Combination With Insulin Degludec With or Without Metformin, in Adults With Type 2 Diabetes (ONSET 9)
Authors: Lane Wendy S. , Favaro Elena , Rathor Naveen , Jang Hak C. , Kjærsgaard Maiken I.S. , Oviedo Alejandra , Rose Ludger , Senior Peter , Sesti Giorgio , Soto Gonzalez Alfonso , Franek Edward 
Published: March 2020

OBJECTIVE
To evaluate the efficacy and safety of fast-acting insulin aspart (faster aspart) compared with insulin aspart (IAsp), both with insulin degludec with or without metformin, in adults with type 2 diabetes not optimally controlled with a basal-bolus regimen.

RESEARCH DESIGN AND METHODS
This multicenter, double-blind, treat-to-target trial randomized participants to faster aspart (n = 546) or IAsp (n = 545). All available information, regardless of treatment discontinuation or use of ancillary treatment, was used for evaluation of effect.

RESULTS
Noninferiority for the change from baseline in HbA1c 16 weeks after randomization (primary end point) was confirmed for faster aspart versus IAsp (estimated treatment difference [ETD] −0.04% [95% CI −0.11; 0.03]; −0.39 mmol/mol [−1.15; 0.37]; P &lt; 0.001). Faster aspart was superior to IAsp for change from baseline in 1-h postprandial glucose (PPG) increment using a meal test (ETD −0.40 mmol/L [−0.66; −0.14]; −7.23 mg/dL [−11.92; −2.55]; P = 0.001 for superiority). Change from baseline in self-measured 1-h PPG increment for the mean over all meals favored faster aspart (ETD −0.25 mmol/L [−0.42; −0.09]); −4.58 mg/dL [−7.59; −1.57]; P = 0.003). The overall rate of treatment-emergent severe or blood glucose (BG)–confirmed hypoglycemia was statistically significantly lower for faster aspart versus IAsp (estimated treatment ratio 0.81 [95% CI 0.68; 0.97]).

CONCLUSIONS
In combination with insulin degludec, faster aspart provided effective overall glycemic control, superior PPG control, and a lower rate of severe or BG-confirmed hypoglycemia versus IAsp in adults with type 2 diabetes not optimally controlled with a basal-bolus regimen.
Use of Premixed Insulin, Metformin, and a Glucagon-Like Peptide 1 Receptor Agonist as a Therapeutic Approach for Uncontrolled Type 2 Diabetes
Authors: Ehrhardt Nicole , Fazeli Sasan , Rao Sanjana , Amdur Richard 
Published: March 2020

OBJECTIVE | To explore the use of premixed insulin, a glucagon-like peptide 1 (GLP-1) receptor agonist, and metformin as combination therapy for type 2 diabetes.
DESIGN AND METHODS | All adult patients with type 2 diabetes who had been prescribed premixed insulin and a GLP-1 receptor agonist simultaneously at our outpatient clinic were selected for retrospective review. We reviewed A1C, weight, cumulative daily insulin dose, and adverse events over 12 months.
RESULTS | A total of 72 patients received premixed insulin and a GLP-1 receptor agonist, of which 32 met inclusion criteria. The average duration of type 2 diabetes for these patients was 14.2 ± 7.1 years. Mean A1C at baseline was 10.5 ± 2.1%. At 12 months, mean A1C was 8.3 ± 1.9%. The change in mean A1C after 12 months was −2.2% (95% CI −3.433 to −1.014, P &lt;0.0001). At 12 months, the mean cumulative insulin dose was 33.3 units less than before the therapy change (95% CI −57.13 to −9.46, P = 0.0030). Average weight change at 12 months was −2.2 kg (95% CI −27.6 to 37.6, P = NS). After 12 months, 61% of included patients (19 of 31) had an A1C ≤8%. Six additional patients were not included in analysis because they stopped the regimen after &lt;3 months because of adverse events.
CONCLUSION | Despite a decreased cumulative daily dose of insulin, patients with historically uncontrolled type 2 diabetes using metformin, premixed insulin, and a GLP-1 receptor agonist in combination experienced improved glycemic control over 12 months. Prospective randomized trials are needed to better assess the potential benefit of this combination therapy.
External Marginal Gap Evaluation of Different Resin-filling Techniques for Class II Restorations—A Micro-CT and SEM Analysis
Authors: Sampaio CS , Garcés GA , Kolakarnprasert N , Atria PJ , Giannini M , Hirata R 
Published: March 2020

Clinical Relevance
Secondary caries are the main reason for the failure of restorations, class II being the most affected. Techniques that promote less gap percentage are important. Flowable bulk fill composites used at such locations have been shown to decrease gap formation while being a faster procedure than an incremental technique.

SUMMARY

Purpose:
To evaluate gap formation of class II restorations, resin-filling techniques using microcomputed tomography (μCT) and scanning electronic microscopy (SEM) are discussed.

Methods and Materials:
Class II cavities were prepared in 30 third molars and analyzed in distal and mesial views. Prime&Bond Universal adhesive was applied in all teeth and divided into five groups (n=6): G1, SS+HIT (Spectra Smart+Horizontal Incremental Technique); G2, SS+OBL (Oblique Incremental Technique); G3, SDR+BFT (Surefil SDR+Bulk Fill Technique); G4, SDR+SS (SDR placed on cervical floors from mesial and distal boxes (not light cured), followed by incremental layering with SS and light curing incrementally with the horizontal technique); and G5, BEZ+BFT (Bulk EZ+BFT). All light-curing procedures were performed with high-mode/1200 mW/cm2, Bluephase Style 20i. Teeth were scanned twice (first scan, empty tooth; second scan, filled tooth after light curing) by μCT. Acquired μCT data were evaluated with software looking for gaps at the external mesial and distal margins and submitted to statistical analysis (one-way analysis of variance and least significant differences post hoc test). Validation of the μCT analysis was performed by SEM.

Results:
G5 showed the lowest gap formation percentage, similar to G4 (p=0.20). G4 also showed statistical similarities to G1 and G3 (p&gt;0.05). G2 showed the highest percentages, similar to G1 (p=0.10) but different from the rest of the groups (p&lt;0.05). SEM validated the μCT technique by showing qualitative similar images regarding external marginal gap.

Conclusions:
The dual-cure composite and the use of flowable nonpolymerized plus horizontal filling technique showed the best marginal adaptations. The μCT technique was validated for visualization of gap formation after being compared to the SEM technique.
Strategi Anti Fraud dalam Pengelolaan Dana Desa
Authors: Poima Agri Christy , Nugraheshty Hapsari Apriana 
Published: March 2020

Peningkatan jumlah kucuran dana desa yang dilakukan pemerintah ternyata tidak sejalan dengan pengelolaan yang baik. Terbukti dengan ditemukannya beberapa kasus fraud dalam pengelolaan dana desa. Penelitian ini bertujuan untuk mengetahui potensi fraud dan strategi anti fraud dalam pengelolaan dana desa di Desa Karangtengah, Kecamatan Tuntang, Kabupaten Semarang. Penelitian ini merupakan penelitian deskriptif kualitatif. Sumber data dalam penelitian ini diperoleh dari data primer melalui wawancara mendalam dan dokumentasi. Teknik analisis yang digunakan yaitu reduksi data, penyajian data dan penarikan kesimpulan. Jenis fraud yang diteliti dalam penelitian ini adalah fraud dalam pelaporan keuangan. Hasil dalam penelitian ini menunjukkan bahwa tidak ditemukannya potensi fraud dalam pengelolaan dana desa karena adanya penerapan strategi anti fraud yang dilakukan di Desa Karangtengah.
Vegetación liquénica epífita de la Sierra del Caurel (Lugo, Galicia).
Authors: Álvarez Josefina , Carballal Regina 
Published: March 2020

RESUMEN. Vegetación liquénica epzfita de la Sierra del Caurel (Lugo, Galicia). Damos cuenta de los resultados del estudio de la vegetación liquénica epifítica de la Sierra del Caurel (Lugo, España), en donde hemos reconocido las siguientes asociaciones: Hypocenomycetum scalaris Hil. 1925, Lecanoretum subfuscae Ochsner 1928, Pertusarietum hemisphaericae Almb. 1948 ex Klem. 1955, Pseudevernietum furfuraceae Almb. 1948, Parmelietumcaperato-perlatae Delzenne & Géhu 1977, Physcietum ascendentis Ochsner 1928 y Nephrometum laevigatae Barkm. 1958.Palabras clave. Vegetación, líquenes, epífitos, Sierra del Caurel, Lugo.SUMMARY. The epiphytic lichenic communities of the Sierra del Caurel (Lugo, Spain). The epiphytic lichenic communities of the Sierra del Caurel (Lugo, Spain) has been studied. The following syntaxa are mentioned: Hypocenomycetum scalaris Hil. 1925, Lecanoretum subfuscae Ochsner 1928, Pertusarietum hentisphaericae Almb. 1948 ex Klem. 1955, Pseudevernietum furfuraceae Almb. 1948, Parnzelietum caperato-perlatae Delzenne & Géhu 1977, Physcietum ascendentis Ochsner 1928 y Nephrometum laevigatae Barkm. 1958.Key Words. Vegetation, lichens, epiphytic, Sierra do Caurel, Lugo.
PEMENUHAN GIZI SEIMBANG BAGI LANSIA DI PULAU GILI IYANG KECAMATAN DUNGKEK
Authors: Pratiwi Iva Gamar dian , Yasin Zakiyah , Suprayitno Emdat 
Published: March 2020

Giliiyang merupakan sebuah pulau yang termasuk dalam wilayah Kecamatan Dungkek Kabupaten Sumenep. Pulau Giliiyang memiliki dua desa yaitu desa Banra’as dan Bancamara.
Menurut data dari Pemerintah Kabupaten Sumenep, jumlah lansia di Pulau Giliiyang yang berusia 60 tahun ke atas mencapai 1.285 orang dan 100 tahun ke atas mencapai 157 orang. Sesuai dari hasil pengkajian hampir 90% lebih lansia di pulau Giliiyang memiliki tingkat pendidikan rendah sehingga salah satu nya berdampak pada pengetahuan yang rendah pula tentang pemenuhan gizi seimbang.
Salah satu kegiatan yang dapat dilakukan oleh kelompok untuk membantu masyarakat menghadapi salah satu hambatan tersebut adalah dengan mengadakan kegiatan penyuluhan sekaligus demonstrasi tentang pemenuhan gizi yang seimbang bagi lansia, sehingga diharapkan dengan adanya penyuluhan tersebut pengetahuan lansia meningkat dan bisa merubah pola hidup mereka menjadi lebih baik khususnya yang berkaitan dengan gizi seimbang. Masyarakat sangat antusias dengan kegiatan penyuluhan kepada masyarakat.
EXTENSION IMPROVE THE QUALITY OF THE CONTRUCTION WORK FORCE IN THE IMPLEMENTATION OF CONTRUCTION PROJECTS
Authors: Fansuri Subaidillah , Diana Anita Intan Nura 
Published: March 2020

Kondisi wilayah Desa Gadu Timur yang terletak di sebelah barat kota sumenep, merupakan wilayah daratan tinggi yang mana kondisi tanah merupakan batuan yang mengakibatkan kurangnya hasil pertanian, sehingga kebanyakan masyarakat Desa Gadu timur memilih sebagai tenaga kerja kontruksi yang merupakan mitra dalam pengabdian kepada masarakat. Berdasarkan analisis situasi yang yang ada di Desa Gadu Timur yang notabeni masyarakatnya merupakan pekerja kontruksi di Kabupaten Sumenep, mereka berharap dengan adanya pengabdian kepada masyarakat ini dapat memberikan pengetahuan tentang seperti apa tenaga kerja kontruksi yang layak dan bisa bersaing dengan tenaga kerja kontruksi dari luar daerah Sumenep.
Hasil kegiatan pengabdian dapat dilihat dari hasil evaluasi yang telah dilakukan dan juga dapat mengetahui hubungan yang terjadi yaitu hubungan antara proses pelaksanaan sosialisasi terhadap pemahaman dari 15 responden. Jawaban responden 1, 2, 3, 5, 14, memiliki tingkat signifikan yang rendah dan hubungan yang lemah, karena memiliki nilai hubungan dan tingkat signifikan = 0. Responden 4 memiliki hubungan yang sangat kuat yaitu terletak diantara 0,70-0,89 pada tabel nilai koefisien korelasi dan signifikan sebab 0,019 < 0,05. Responden 6 memiliki hubungan yang lemah yaitu terletak diantara 0,10-0,29 pada tabel nilai koefisien korelasi dan tidak signifikan sebab 0,665 > 0,05. Responden 7, 8, 9, 10, 15 memiliki hubungan yang lemah yaitu terletak diantara 0,10-0,29 pada tabel nilai koefisien korelasi dan tidak signifikan sebab 0,452 > 0,05. Responden 8, 12, 13 memiliki hubungan yang mendekati sempurna karena terletak >0,90pada tabel nilai koefisien korelasi yaitu 0,941 dan signifikan sebab 0,00 < 0,01