bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Preliminary Study on the Architectural Design of Chinese Hospitals in Virus Era
Authors: Cui Zhang 
Published: July 2020

Abstract
After the new Corona Virus Disease 2019 (COVID-2019), we have many new ideas for architectural design, more emphasis on epidemic prevention issues, designers in the functional design to meet the needs of medical staff and patients to use the design of the hospital, The assembly of hospital buildings is not only a transformation of construction methods, but also an upgrade of design concepts, which is a direction for future hospital development.
The Practice and Enlightenment of Architectural Renovation and Urban Renewal in the Netherlands
Authors: Jing Liping , Sun Leilei , Zhu Fengji 
Published: July 2020

Abstract
With the development of local urban renewal in the Netherlands, Dutch architects as Rem Koolhass, Francine Houben and Kees Kaan, etc. have showed rich practical experiences. As a result, the architectural renovation and urban renewal have presented a thriving scene. In this article, the types of urban renewal in the Netherlands are classified as three main categories: regional renewal, architectural heritage refurbishment, and adaptive reuse [1]. From the perspective of types to strategies, this study analyzes typical cases including the Westerpark West, Speelhuis theater, Timmerhuis and Villa Industria and so on, exploring the role of Dutch architects, the method of transformation and sustainable meaning of urban renewal. The research tries to summarize the Dutch mode and experiences, providing a new perspective and methodology for relevant transformation practices of urban renewal in China.
Study on Technical Standards Implementation Benefit Evaluation Practice
Authors: Hu Yuan , Tang Chenghui , Liang Cai 
Published: July 2020

Abstract
This paper has successively analysed and compared the practice of the United Kingdom, Germany, France, Canada, Japan, ISO and other countries and organizations in the evaluation of standardization economic benefits. And then a new method is proposed for large enterprises to carry out technical standard implementation benefit evaluation. Finally, case study for power company A and B validates the effectiveness of the proposed method.
Research on The Layout of Express Delivery Outlets in Jinan City
Authors: Zhang Yu , Su Mingyue , Cai Chuge , Liu Ziye , Zhang Dongli , Han Lulu 
Published: July 2020

Abstract
The layout of express delivery outlets is the key content of express delivery network organization. The organizational construction of a regional express network should consider multiple aspects, including the number of outlets, the location of outlets and the size of outlets. The construction level of express delivery outlets is directly related to the success of the future development of joint distribution model. This paper analyzes the factors that affect the number and location of express outlets in Jinan. And this paper obtains the distribution of express outlets in Jinan city by establishing mathematical model.
The Influence of Control Point Distribution of Unmanned Aerial Vehicles for the Results of Aerial Stitching
Authors: Hsu Chun-Li , Huang Hsiu-Hui 
Published: July 2020

Abstract
Unmanned aerial vehicles are an important development direction for today’s aviation telemetry technology, and have gradually become an essential technology for three-dimensional space acquisition. To date, the flight stability of unmanned aerial vehicles has been greatly improved, and space positioning is miniaturized, which ensures the UAV to play the most role in battery life, image real-time transmission, high-risk area detection and other occasions. In the past, natural disasters relied on traditional technology to obtain local conditions, thus, it was impossible to obtain immediate on-site information. However, the immediacy and convenience of unmanned aerial vehicles have been used to grasp the immediate situation of disaster relief sites, providing information for substantial benefits to disaster relief related units. In this study, Pix4Dmapper image processing software is used to quickly create orthophotos, thus, three-dimensional terrain elevation models of stereoscopic view and terrain data can be constructed. The captured images are spliced through the software, and the measurement accuracy of the aerial stitching images is discussed according to the different distribution positions of the control points. The results show that the number of control points is too small to improve accuracy. Regarding the study area, the optimal distribution route of 20 control points is the best. In more complex terrain, the control points should be selected at locations that contain various elevation changes. If it is not possible to evenly arrange the control points, it is recommended to select the circular route method.
Research and Design of Operation Mode and Risk Control Model of Finance
Authors: Yu Ziqiang , Wang Jiahui , Qin Liwei 
Published: July 2020

Abstract
The finance warehouse is a kind of service innovation of logistics and finance integration, and its innovative operation mode provides a new channel for SME financing. Firstly, the risk control model of finance warehouse is studied, designed and tested; on the basis of controlling regulatory risk and credit risk, the efficiency coefficient method of evaluation model is adjusted and improved; then the process of operation mode and the characteristics of each mode are studied and designed.
Research on Performance Evaluation System of Innovative Pharmaceutical Enterprises Based on Balanced Scorecard——Taking CCS1 WuXi AppTec as an Example2
Authors: Wang Yan , Liu Jiaan 
Published: July 2020

Abstract
With the reform of medical system, China’s pharmaceutical industry has entered a period of adjustment and transformation with steady development. The comprehensive performance evaluation of pharmaceutical companies is conducive to understanding the overall operation and development potential of the pharmaceutical industry in China, and has reference significance for the decision-making of all stakeholders. Based on the balanced scorecard, this paper designs a comprehensive performance evaluation system at the financial and non-financial levels, using scientific and effective evaluation methods to analyse the performance of pharmaceutical industry companies, which will play an important role in improving the comprehensive performance evaluation of pharmaceutical industry companies.
Comprehensive Evaluation on Safety Management of Road Dangerous Goods Transportation Enterprises Based on Multi-level Gray Relational Analysis
Authors: Wang Li , Jin Chunling , Li Chuanghong 
Published: July 2020

Abstract
It is helpful to improve the safety management level of enterprises to carry out the comprehensive evaluation on safety management of the road transport enterprises of dangerous goods, and to reduce road safety accidents. Based on the analysis of the risk factors of road transport of dangerous goods, this paper constructs a comprehensive evaluation index system for the safety of the road transport enterprise with the AHP method, and gives the weight of each evaluation index. Combined with the instance, the correlation size between each evaluated enterprise and the virtual “best enterprise” is calculated by using gray relational analysis model, so as to identify the pros and cons of the safety management level of each evaluated enterprise, and provide reference for comprehensive safety evaluation of road transportation enterprises of dangerous goods.
Comparative Analysis of the Mechanism of Engineering Project Management Standardization
Authors: Liu Longhua 
Published: July 2020

Abstract
With the improvement of engineering project performance and the need for theoretical innovation, the importance of standardized research on engineering project management has become increasingly important. Based on the results of the questionnaire survey, and on the basis of testing the reliability and validity of the questionnaire, the hierarchical regression analysis was used to study the mechanism between the influencing factors of engineering project management standardization and process performance, cooperation performance, knowledge accumulation, and engineering project performance. And test the hypotheses. In order to further improve the effect of engineering project management, it is quite necessary to carry out research on engineering project management. However, due to the lack of a substantial amount of substantial research in the actual research process, we have mainly carried out in-depth research on engineering project management standardization.
Genetic Algorithm for Optimizing Components of Mine Tailings Curing Agent
Authors: Cui Yiyuan , Mei Guodong , Wang Shan 
Published: July 2020

Abstract
Mine tailings harmless disposal is priority research in mining industry. Although a number of tailings disposal methods have been developed in the past, surface stacking still remains a major challenge in engineering. A key to realizing mine tailings surface stacking is developing high efficient curing agent to enhance the strength of consolidated tailings. In this study, an optimal approach based on genetic algorithm is developed for determining the best ratio of components. The proposed optimal approach succeeds in improving the compressive strength of consolidated tailings compared with orthogonal test. In addition, the developed optimal approach takes less test time than orthogonal test, which saves materials and shortens experimental time. The results indicate that a better compressive strength of consolidated tailings is achieved by the optimal curing agent based on genetic algorithm.
Transport Waste Separation and Recovery Trajectory Judged Based on Dijkstra’s Algorithm
Authors: Sun Yanbin , Shen Penglin , Jiang Huimin , Zhang Yuehua , Guan Jinqiu , Li Lan 
Published: July 2020

Abstract
Urban waste classification and recycling is an important research node in people’s livelihood, which is related to the corresponding relationship between efficiency and quality. The optimization of the recycling transportation path means that the cost is less. In the process of garbage transportation classification and recycling, optimizing and merging the routes of garbage transportation based on Dijkstra’s algorithm can optimize the shared transportation resources, to achieve the result of saving operating costs. The immediate transportation recycling event is planned as the path planning optimization. Multi-source multi-object and multi-path planning problems, and rehearse the optimization model of the total length of the transport path set without repeated paths. When the scale of the transportation and recovery network grows to a set value, it is difficult to achieve a theoretical solution by accurately calculating the optimal value of the model through an optimization algorithm. An optimal path set selection algorithm based on a random walk is feasible. The effectiveness and operability of the method are verified by small experiments and simulation experiments. The path is the shortest, and compared with the summation algorithm, it not only has high accuracy, but also has high execution efficiency.
Research on the test method for composite threshold of subway platform door
Authors: Feng Shuangchang , Niu Kuangye , Zeng Xiaoyi , Yang Yuqing 
Published: July 2020

Abstract
At present, subway platform doors have become the standard configuration of Chinese subways due to the advantages of energy saving, environmental protection, passenger safety, and improvement of the waiting environment. In order to solve the problem of insulation failure of traditional platform door thresholds, threshold manufacturers use composite materials with their own insulating properties to manufacture composite thresholds. Instead of the aluminium alloy and stainless steel structures commonly used in the industry, the composite threshold uses polymer composite as the basic carrier, and then covers the aluminium alloy panel on the surface of the basic carrier. The non-metallic material of the composite threshold has a unique advantage in insulation, but its mechanical properties still need to be verified by experiments. In view of the lack of test method for the compound threshold of subway platform doors, this paper formulates the method for the composite threshold of platform door based on the test method of escalator steps. PWS-20 electro-hydraulic servo cascade fatigue testing machine was used as the test equipment. The static load test and dynamic load test were carried out on the composite threshold samples respectively. When a force of 1000N is applied for the static load test, the maximum deflection value is 0.919mm. After 1 million cycles of dynamic load test with a non-interfering resonance force wave with a frequency of 5 Hz and a pulsating load between 50N and 1000N, no cracks were observed in the sample. For the composite threshold made of other materials, this test method can also be used to carry out static load test and dynamic load test.
Study on Material Model and Pressure Distribution Characteristics of Off-highway Minning Dump Truck Bucket
Authors: Hao Ni Ni , Jiang Xue 
Published: July 2020

Abstract
In view of the existing problems in the calculation method of the external contour of the material accumulation of the off-highway mining dump truck bucket, the reverse engineering technology and the 3D laser scanning method are proposed to accurately obtain the 3D model of the material distribution in the truck bucket. Based on the three-dimensional solid model of the material, the pressure formulas of the front plate, the side plate and the bottom plate of the bucket are derived by the force analysis method based on the thin-layer element method. References for the structure design and performance analysis of dump truck bucket are provided.
Particle swarm optimization for wavefront correction in ophthalmic applications
Authors: Beeck Andreas , Muckenhirn Stefan , Herkommer Alois 
Published: July 2020

Abstract
Many optical systems require the correction of the cumulative wavefront error of the system for performance optimization. In ophthalmology the wavefront error of the eye corresponds to the visual defect and can be measured up to high-order aberrations today. Lower orders of the wavefront error are usually corrected with spectacles, contact lenses or refractive surgery. In this paper we apply an optimization method called particle swarm optimization to calculate the optimal correction for visual defects based on measured high-order wavefront results. It is shown that an optimized conventional correction and in particular an extended wavefront correction including higher orders yields a better result for the visual Strehl ratio, as compared to a simple conjugate correction scheme.
The efflorescent carbon allotropes: fractality preserved blooming through alkali treatment and exfoliation
Authors: Swapna M S , Sankararaman S 
Published: July 2020

Abstract
The work reported in the paper elucidates morphological modification induced nanoart and surface area enhancement of graphite, graphene, and soot containing carbon allotropes through ultrasonication and alkali-treatment. The field emission scanning electron microscopic (FESEM) analysis of the samples before and after exfoliation reveals the formation of brilliant flower-like structures from spindle-like basic units due to Ostwald ripening. The x-ray diffraction analysis of the samples gives information about structural composition. The fractal analysis of the FESEM images indicates a multifractal structure with the dimensions—box-counting dimension D0 (1.72), information dimension D1 (1.66), and correlation dimension D2 (1.63)—preserved upon exfoliation. The process of ultra-sonication assisted liquid phase exfoliation resembles blooming as if the carbon allotropes are efflorescent.
Potentially inappropriate prescribing in dementia, multi-morbidity and incidence of adverse health outcomes
Authors: Delgado João , Jones Lindsay , Bradley Marie C , Allan Louise M , Ballard Clive , Clare Linda , Fortinsky Richard H , Hughes Carmel M , Melzer David 
Published: July 2020

Abstract

Importance
treatment of dementia in individuals with comorbidities is complex, leading to potentially inappropriate prescribing (PIP). The impact of PIP in this population is unknown.

Objective
to estimate the rate of PIP and its effect on adverse health outcomes (AHO).

Design
retrospective cohort.

Setting
primary care electronic health records linked to hospital discharge data from England.

Subjects
11,175 individuals with dementia aged over 65 years in 2016 and 43,463 age- and sex-matched controls.

Methods
Screening Tool of Older Persons’ Prescriptions V2 defined PIP. Logistic regression tested associations with comorbidities at baseline, and survival analyses risk of incident AHO, adjusted for age, gender, deprivation and 14 comorbidities.

Results
the dementia group had increased risk of PIP (73% prevalence; odds ratio [OR]: 1.92; confidence interval [CI]: 83–103%; P &lt; 0.01) after adjusting for comorbidities. Most frequent PIP criteria were related to anti-cholinergic drugs and therapeutic duplication. Risk of PIP was higher in patients also diagnosed with coronary-heart disease (odds OR: 2.17; CI: 1.91–2.46; P &lt; 0.01), severe mental illness (OR: 2.09; CI: 1.62–2.70; P &lt; 0.01); and depression (OR: 1.81; CI: 1.62–2.01; P &lt; 0.01). During follow-up (1 year), PIP was associated with increased all-cause mortality (hazard ratio: 1.14; CI: 1.02–1.26; P &lt; 0.02), skin ulcer and pressure sores (hazard ratio: 1.66; CI: 1.12–2.46; P &lt; 0.01), falls (hazard ratio: 1.37; CI: 1.15–1.63; P &lt; 0.01), anaemia (hazard ratio: 1.61; CI: 1.10–2.38; P &lt; 0.02) and osteoporosis (hazard ratio: 1.62; CI: 1.02–2.57; P &lt; 0.04).

Conclusion
patients with dementia frequently receive PIPs, and those who do are more likely to experience AHO. These results highlight the need to optimise medication in dementia patients, especially those with comorbidities.
Suptavumab for the Prevention of Medically Attended Respiratory Syncytial Virus Infection in Preterm Infants
Authors: Simões Eric A F , Forleo-Neto Eduardo , Geba Gregory P , Kamal Mohamed , Yang Feng , Cicirello Helen , Houghton Matthew R , Rideman Ronald , Zhao Qiong , Benvin Sarah L , Hawes Alicia , Fuller Erin D , Wloga Elzbieta , Pizarro Jose M Novoa , Munoz Flor M , Rush Scott A , McLellan Jason S , Lipsich Leah , Stahl Neil , Yancopoulos George D , Weinreich David M , Kyratsous Christos A , Sivapalasingam Sumathi 
Published: July 2020

Abstract

Background
Respiratory syncytial virus (RSV) is a major cause of childhood medically attended respiratory infection (MARI).

Methods
We conducted a randomized, double-blind, placebo-controlled phase 3 trial in 1154 preterm infants of 1 or 2 doses of suptavumab, a human monoclonal antibody that can bind and block a conserved epitope on RSV A and B subtypes, for the prevention of RSV MARI. The primary endpoint was proportion of subjects with RSV-confirmed hospitalizations or outpatient lower respiratory tract infection (LRTI).

Results
There were no significant differences between primary endpoint rates (8.1%, placebo; 7.7%, 1-dose; 9.3%, 2-dose). Suptavumab prevented RSV A infections (relative risks, .38; 95% confidence interval [CI], .14–1.05 in the 1-dose group and .39 [95% CI, .14–1.07] in the 2-dose group; nominal significance of combined suptavumab group vs placebo; P = .0499), while increasing the rate of RSV B infections (relative risk 1.36 [95% CI, .73–2.56] in the 1-dose group and 1.69 [95% CI, .92–3.08] in the 2-dose group; nominal significance of combined suptavumab group vs placebo; P = .12). Sequenced RSV isolates demonstrated no suptavumab epitope changes in RSV A isolates, while all RSV B isolates had 2–amino acid substitution in the suptavumab epitope that led to loss of neutralization activity. Treatment emergent adverse events were balanced across treatment groups.

Conclusions
Suptavumab did not reduce overall RSV hospitalizations or outpatient LRTI because of a newly circulating mutant strain of RSV B. Genetic variation in circulating RSV strains will continue to challenge prevention efforts.

Clinical Trials Registration
NCT02325791.
Normal Ranges of Thiopurine Methyltransferase Activity Do Not Affect Thioguanine Nucleotide Concentrations With Azathioprine Therapy in Inflammatory Bowel Disease
Authors: Jonason David E , Sievers Tyson , Trocke Lindsay , Abraham James M , Vaughn Byron P 
Published: July 2020

AbstractBackgroundThiopurine methyltransferase (TPMT) activity influences azathioprine conversion into active metabolite 6-thioguanine nucleotide (6-TGN). Low TPMT activity correlates with high 6-TGN and risk for myelosuppression. Conversely, normal-to-high TPMT activity may be associated with low 6-TGN and drug resistance, the so-called hypermetabolizers. Our aim was to identify the effect of normal-to-high TPMT activity on 6-TGN concentrations in an inflammatory bowel disease population.MethodsA retrospective chart review of patients aged ≥18 with inflammatory bowel disease, on azathioprine, with documented TPMT activity and 6-TGN concentration was performed. Correlations were evaluated via the Spearman rho correlation coefficient. Linear regression was used to determine the effect of TPMT activity on 6-TGN accounting for confounders. Relationships between TPMT activity, drug dose, and 6-TGN levels were defined via average causal mediation effects.ResultsOne hundred patients were included. No correlation was observed between TPMT activity, azathioprine dosing, and metabolite concentrations. Overall, 39% of the cohort had a therapeutic 6-TGN level of &gt;230 pmol/8 × 108 red blood cells (RBCs). No patient under 1 mg/kg achieved a therapeutic 6-TGN level, whereas 42% of patients taking 2.5 mg/kg did. The median 6-TGN concentration was higher for those in remission (254 pmol/8 × 108 RBCs, interquartile range: 174, 309) versus those not in remission (177 pmol/8 × 108 RBCs, interquartile range: 94.3, 287.8), though not significantly (P = 0.08). Smoking was the only clinical factor associated with 6-TGN level. On multivariate linear regression, only age, azathioprine dose, and obese body mass index were predictive of metabolite concentration.ConclusionsVariations within the normal range of TPMT activity do not affect 6-TGN concentration.
Gut Microbiota-driven Drug Metabolism in Inflammatory Bowel Disease
Authors: Crouwel Femke , Buiter Hans J C , de Boer Nanne K 
Published: July 2020

Abstract

Background and Aims
The gut microbiota plays an important role in the metabolization and modulation of several types of drugs. With this study we aimed to review the literature relating to microbial drug metabolism of medication prescribed in inflammatory bowel disease [IBD] practice.

Methods
A systematic literature search was performed in Embase and PubMed from inception to October 2019. The search was conducted with predefined MeSH/Emtree and text terms. All studies regarding drug metabolism by microbiota of medication prescribed in IBD practice were eligible. A total of 1018 records were encountered and 89 articles were selected for full text reading.

Results
Intestinal bacterial metabolism or modulation is of influence in four specific drugs used in IBD (mesalazines, methotrexate, glucocorticoids and thioguanine). The gut microbiota cleaves the azo-bond of sulfasalazine, balsalazide and olsalazine and releases the active moiety 5-aminosalicylic acid. It has an impact on the metabolization and potentially on the response of methotrexate therapy. In particular, thioguanine can be converted by intestinal bacteria into the pharmacologically active 6-thioguanine nucleotides without the requirement of host metabolism. Glucocorticoid compounds can be prone to bacterial degradation.

Conclusion
The human intestinal microbiota can have a major impact on drug metabolism and efficacy of medication prescribed in IBD practice. A better understanding of these interactions between microbiota and drugs is needed and should be an integral part of the drug development pathway of new IBD medication.