bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economic security of tourism in Germany: models for overcoming the crisis
Authors: Slyvenko Vyacheslav , Slyvenko Oleksii 
Published: November 2020

Purpose – to analyze the models of overcoming the crisis of the tourism business in Germany.
Design/Method/Approach of the research. The research method is an expert opinion analysis on possible scenarios for the Covid-19/Coronavirus pandemic crisis development, the consequences for German tourism, and possible models of overcoming the crisis.
Findings. The paper analyzes the models of overcoming the crisis in Germany's tourism business during the gradual attenuation of the Covid-19/ Coronavirus pandemic and the beginning of the national borders lento opening. That allowed us to formulate an assumption of possible scenarios while crisis overcoming in the tourism business in Germany.
Theoretical and practical implications. The analysis of possible scenarios while overcoming the crisis in the tourism business in Germany phenomena in Germany's tourism industry can be very interesting both for practitioners and for theorists studying the problems of tourism development worldwide.
Originality/Value. The article investigates the regional differences of the tourism crisis developed during the Covid-19/ Coronavirus pandemic. Based on a logical analysis of the models for overcoming the tourism business crisis in Germany, the paper analyzed factors that can affect changes in consumer habits and include vital economic aspects of the tourism business restoration. This paper expands researchers’ capabilities in the crisis phenomena analysis in the tourism business and assists in the most accurate and reasonable forecasting for the long-term sustainable development and competitive advantages of tourism enterprises.
Paper type – theoretical.
Keywords: tourism business; model; crisis; Covid-19/Coronavirus pandemic.
PENGARUH ROL DINGIN DAN ANIL TERHADAP KARAKTERISTIK STRUKTUR MIKRO DAN KEKERASAN MIKRO PADUAN Zr-0,5%Nb-Si
Authors: Hardiyanti Heri , Adhi Arief Sasongko , Setiawan Jan 
Published: November 2020

PENGARUH ROL DINGIN DAN ANIL TERHADAP KARAKTERISTIK STRUKTUR MIKRO DAN KEKERASAN MIKRO PADUAN Zr-0,5%Nb-Si. Peningkatan kinerja paduan zirkonium dilakukan dengan menambahkan unsur pemadu yang umum seperti Nb dan Si dengan persentase tertentu. Penambahan unsur Nb akan memberikan pengaruh terhadap struktur mikro yang memberikan ketahanan terhadap iradiasi dan membantu menstabilkan fasa β di temperatur kamar, yang terbentuk pada temperatur tinggi. Penambahan unsur Si, akan meningkatkan kekuatan paduan. Telah dilakukan proses sintesis paduan Zr-0,5%Nb-Si dengan menggunakan tungku busur listrik. Paduan ini diamati struktur mikro dan kekerasan mikronya dengan perlakukan proses rol dingin dan perlakuan panas anil. Terlihat dari proses anil tanpa proses rol dingin, menunjukan pembesaran ukuran butir dan penurunkan kekerasan mikro. Paduan yang diberi perlakuan proses rol dingin menunjukkan perubahan struktur mikro di mana densitas deformasi meningkat yang mengakibatkan peningkatan kekerasan mikro. Pemberian perlakuan panas pada paduan yang telah diproses rol dingin mengubah struktur mikro paduan di mana terjadi rekristalisasi dan penurunan densitas deformasi mengakibatkan kekerasan mikro menurun. Ukuran butir dan kekerasan mikro yang paling rendah terjadi pada paduan yang diproses rol dingin ε=0,8 dan dilanjutkan proses anil, dengan nilai berturut-turut sebesar 0,302 mm dan 187 HVN.Kata kunci: rol dingin, rekristalisasi, struktur mikro, kekerasan mikro, paduan Zr-Nb-Si
«Троица» Андрея Рублева: загадка и разгадка
Authors: Иванюшкин Иван Александрович 
Published: November 2020

<p class="Default">Статья посвящена историческим событиям первой половины XX в., связанным с сохранением русских святынь в суровые годы большевистских гонений на церковь. Изложена история расчистки иконы «Троица» Андрея Рублева. Описаны обстоятельства сокрытия части мощей преподобного Сергия Радонежского от поругания большевиками в 1920–1940 гг. Показана роль П. А. Флоренского, Ю. А. Олсуфьева и архиепископа Сергия (Голубцова) в этих событиях.</p><p class="Default">Автор статьи проводит искусствоведческую параллель между традицией русской иконописи и жанром советского плаката. Факт появления в 1919 г. плаката Д. Моора «Советская Россия — осажденный лагерь. Все на оборону!» расценивается как символ моральной деформации в сознании русского народа в годы Гражданской войны.</p><p class="Default">В статье предложен опыт богословского прочтения иконы «Троица» Андрея Рублева посредством обращения к работе Г. С. Дунаева «Символический язык “Троицы” Рублева». Показана актуальность философского наследия П. А. Флоренского для понимания смысла иконы «Троица». Изложена история публикации работы П. А. Флоренского «Иконостас» в советское время. Автор отмечает особенности существования и восприятия «Троицы» в условиях современного музея, размышляет над необходимостью преодоления антихристианских тенденций эпохи постмодерна. Предлагается понимание «Троицы» Андрея Рублева как нравственного идеала в контексте истории русского народа.</p>
Ukrainian Greek Catholic Church’s stance vis-à-vis terrorist activities of Ukrainian nationalists in the early 1930s
Authors: Ryba Mieczysław 
Published: November 2020

Stanowisko ukraińskiego Kościoła greckokatolickiego wobec działań terrorystycznych ukraińskich nacjonalistów na początku lat trzydziestych XX w.
Artykuł dotyczy reakcji Kościoła greckokatolickiego na zamachy terrorystyczne organizowane na ziemiach polskich przez nacjonalistów ukraińskich w latach trzydziestych XX w. Biskupi greckokatoliccy (Andrzej Szeptycki, Jozafat Kocyłowski, Grzegorz Chomyszyn) poparli budowę państwa ukraińskiego w 1918 r. Po klęsce Ukraińców w wojnie z Polską w 1919 r. rozwinął się w Małopolsce Wschodniej ruch nacjonalistyczny, znacząco odbiegający w swych podstawach ideowych od zasad chrześcijańskich. Szczególne wzmożenie owego nacjonalizmu nastąpiło na przełomie lat dwudziestych i trzydziestych XX w. Z jednej strony nasiliły się zamachy terrorystyczne Ukraińskiej Organizacji Wojskowej oraz Organizacji Ukraińskich Nacjonalistów, z drugiej coraz większy wpływ na Ukraińców wywierała szowinistyczna ideologia Dmytra Doncowa. Wszystko to powodowało niepokój wśród ukraińskich biskupów. Pojawiły się ostre reakcje na zamachy, szczególnie ze strony biskupa Grzegorza Chomyszyna, który potępił pogański nacjonalizm i wszystkie jego przejawy. Trochę mniej ostro wypowiadał się w tej sprawie metropolita Andrzej Szeptycki, co wywoływało kontrowersje między oboma pasterzami.
ECONOMIC ANALYSIS OF DIFFERENT IRRIGATION DEPTHS IN FORAGE SORGHUM CROPS
Authors: RODRIGUES DE SOUSA PAULO GLEISSON , DE ARAÚJO VIANA THALES VINÍCIUS , DE CARVALHO CLAYTON MOURA , FIRMIANO DE SOUSA JOSÉ DE PAULA , CAMPOS KILMER COELHO , DE AZEVEDO BENITO MOREIRA 
Published: November 2020

The objective of this work was to evaluate the production costs and profitability indexes of sorghum crop for silage production under different irrigation depths. The work was conducted at the Federal Institute of Education, Science and Technology of Ceará (IFCE) – Umirim Campus, from September to December 2016. The treatments were arranged in 5 x 5 split plots with 5 replications. Irrigations were performed on a daily basis, and the applied depths were calculated based on crop evapotranspiration (ETc). The primary treatments were 50, 75, 100, 125 and 150% of ETc, associated with different levels of carnauba bagana mulch (0.00, 2.50, 3.75, 5.00, and 6.25 cm). Effective Operating Cost (EOC), Total Operating Cost (TOC), Gross Revenue (GR), Operating Profit (OP), Profitability Index (PI) and Break-Even Price (BEP) were estimated. According to the indicators analyzed, it was found that this is a promising crop within the different agricultural production schools, with favorable rates for the producer. The variety evaluated presents high resistance as to the water limitation factor, showing positive indicators such as break-even point below the average prices practiced in the region.
In dogs undergoing anaesthesia do pre-anaesthetic gastroprotectants reduce gastro-oesophageal reflux?
Authors: Barry Leanne 
Published: November 2020

PICO question
In dogs undergoing anaesthesia do pre-anaesthetic gastroprotectants reduce gastro-oesophageal reflux?

Clinical bottom line
Category of research question
Treatment
The number and type of study designs reviewed
Five papers were critically reviewed. There was a randomised prospective study, two randomised blinded prospective studies, randomised non-blinded prospective study and a randomised, double blinded and placebo-controlled prospective study.
Strength of evidence
Moderate
Outcomes reported
Evidence of high quality suggests omeprazole or cisapride with esomeprazole decrease the incidence of gastro-oesophageal reflux (GOR) in the anaesthetised dog. In addition, a study of lower quality showed that continuous infusion of metoclopramide at a higher than normal dose rate decreased the incidence of GOR.
Conclusion
Omeprazole or cisapride with esomeprazole decreases the incidence of GOR in the anaesthetised dog.

How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision-making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care
The effect of anti-cancer and anti-tuberculosis treatments in lung cancer patients with active tuberculosis: a retrospective analysis
Authors: CHAI MEI , Shi Qingming 
Published: November 2020

Abstract
BackgroundLung tuberculosis (TB) and lung cancer have a complex relationship. Data concerning TB treatment in lung cancer patients are still incomplete. The aim of this study was to investigate the effects of anti-cancer and anti-tuberculosis treatments in lung cancer patients with active lung TB.MethodsIn a retrospective cohort study, lung cancer patients with active lung TB were identified between January 2013 and December 2016. Age- and sex-matched lung cancer patients without tuberculosis were selected as control subjects. Anti-cancer and anti-tuberculosis treatments were administered according to the national guidelines. The clinical courses and responses of lung cancer patients with and without active lung TB were examined and compared.ResultsA total of 31 consecutive lung cancer patients were diagnosed with active lung TB. Fifty-one lung cancer patients without TB were enrolled as control subjects. Most patients in the two groups were elderly, had advanced non-small cell lung cancer and had tumor burdens. The anti-cancer treatment completion rate and response rate were not different between two group (87.1% in TB treatment patients vs. 92.2% in lung cancer patients; 77.4% in TB treatment patients vs. 88.2% in lung cancer patients, respectively). The anti-tuberculosis treatment completion rate and success rate was 87.1% and 80.7%. The median survival times were not different between two groups (52 weeks in TB treatment patients vs. 57 weeks in lung cancer patients). The change in Karnofsky performance score was also not different between two groups. The most common side effect in TB treatment patients was liver injury (61.3%). The most serious side effect in TB treatment patients was leukocyte deficiency (9.7% in Grade 3). Both of side effects mentioned above were not different between two groups.ConclusionBoth anti-cancer and anti-tuberculosis treatments can be safely and effectively administered in lung cancer patients with active lung TB. Attention should be paid to the risk of tuberculosis in lung cancer patients in TB high-burden countries.
Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: A meta-analysis based on 24 studies
Authors: Imani Danyal , Eslami Mohammad Masoud , Sarab Gholamreza Anani , Aliyu Mansur , Razi Bahman , Rezaei Ramazan 
Published: November 2020

Abstract
Background: Previous studies evaluated the association of IL-4 C33T polymorphism and risk of bronchial asthma but failed to establish a consistent conclusive association. In the present meta-analysis, we intend to define a more reliable estimate of the association in the presence of filling published literature.Methods: An exhaustive search in Web of Science, Scopus, and PubMed databases was performed to identify all relevant publications before September 2020, and 24 publications (28 studies) with 6587 cases and 8408 controls were included in final analysis. The association between polymorphism and risk of asthma were measured by Odd ratios (ORs) and 95% confidence intervals (CIs). Moreover, Cochran's Q and the I2 statistics were used to evaluate the degree of heterogeneity between studiesResults: In the overall study populations, a significant positive association was detected under all genotype models and announced the IL-4 C33T polymorphism as a potential risk factor in the pathogenesis of asthma. In the subgroup analysis by age, a significant association between IL-4 C33T polymorphism and risk of asthma in different age groups was identified in allelic model, which highlighted the predisposing role of the T allele for the asthma risk in all three age groups. Furthermore, the results of subgroup analysis by continent were heterogenous. Accordingly, IL-4 C33T polymorphism was a risk factor in Europeans (all models except heterozygote comparison), Americans (all models except recessive and homozygote comparison) and Asians (just recessive and allelic model). Finally, the ethnicity-specific analysis disclosed a significant association between IL-4 C33T polymorphism and asthma risk in Caucasians (all genotype models except heterozygote comparison), while this association was not significant in African-Americans.Conclusions: This study suggests that IL-4 C33T polymorphism potentially acts as a risk factor for asthma in different ethnicities and age groups.
Feature-driven classification reveals potential comorbid subtypes within childhood apraxia of speech
Authors: Stein Catherine , Benchek Penelope , Miller Gabrielle , Hall Noémi B. , Menon Dhanya , Freebairn Lisa , Tag Jessica , Vick Jennell , Taylor H. Gerry , Lewis Barbara A. , Iyengar Sudha K. 
Published: November 2020

Abstract
Background: Childhood apraxia of speech (CAS) is a neurodevelopmental disorder with heterogeneous communication and other comorbid manifestations. While previous studies have characterized speech deficits associated with CAS, few studies have examined variability in reading and language and/or other developmental comorbidities. We sought to identify comorbid subgroups within CAS that could be clinically relevant as well as genetically distinctive. Methods: In a group of 31 children with CAS and 8 controls, we performed hierarchical cluster analysis utilizing measures of articulation, vocabulary, and reading. We also conducted a chart review of the children with CAS to examine other clinical characteristics in these children and their association with subgroup membership. Results: We identified 3 comorbid subgroups within CAS of varying severity. The high severity subgroup was characterized by poor reading and vocabulary, and the moderate severity subgroup by poor reading and non-word repetition but average vocabulary, compared to the mild severity subgroup. Subgroups were indistinguishable with respect to speech sound production, the hallmark of CAS, all demonstrating poor articulation. Children in the most severe subgroup were more likely to have early problems feeding (p=0.036). Conclusions: Children with CAS may potentially be classified into comorbidity groups based on performance on vocabulary and reading measures, providing additional insight into the heterogeneity within CAS with implications for educational interventions.
Altered Tyrosine Phosphorylation of Cardiac Proteins Prompts Contractile Dysfunction in Hypertrophic Cardiomyopathy
Authors: Xu Mingguo , Bermea Kevin , Ayati Marzieh , Yang Xiaomei , Fu Zongming , Heravi Amir , Zhang Xinyou , Na Chan-Hyun , Everett Allen , Gabrielson kathleen , Foster D Brian , Paolocci Nazareno , Murphy Anne Margaret , Ramirez-Correa Genaro 
Published: November 2020

Abstract
Altered Serine/Threonine phosphorylation of the cardiac proteome is an established hallmark of heart failure (HF). However, the contribution of tyrosine phosphorylation to the pathogenesis of these diseases remains unclear. The cardiac proteome was explored by global mapping to discover and quantify site-specific tyrosine phosphorylation in two cardiac hypertrophic models; cardiac overexpression of ErbB2 (TgErbB2) and cardiac expression of α-Myosin heavy chain R403Q (R403Q-αMyHCTg) compared to control hearts. Phosphoproteomic changes found in R403Q-αMyHC Tg mice indicated EGFR1, Focal Adhesion, VEGF, ErbB signaling, and Chemokine signaling pathways activity were likely to be activated. On the other hand, TgErbB2 mice findings displayed significant overrepresentation of Right Ventricular Cardiomyopathy, Hypertrophic Cardiomyopathy (HCM), and dilated cardiomyopathy (DCM) KEGG Pathways. In silico kinase-substrate enrichment analysis (KSEA) highlighted a marked downregulation of canonical MAPK Pathway Activity downstream of k-Ras in TgErbB2 mice and activation of EGFR, PP2 inhibition of c-Src, and Hepatocyte growth factor stimulation. In vivo ErbB2 inhibition by AG-825 decreased cardiac fibrosis, cardiomyocyte disarray, and rescued contractile function on TgErbB2 mice. These results suggest that altered tyrosine phosphorylation may play a regulatory role in cardiac hypertrophic models, suggesting that tyrosine kinase inhibitors could be used therapeutically in Hypertrophic Cardiomyopathy.
Accessing the Frank-Kasper Phase of Block Copolymer in the Fuzzy Colloid Regime
Authors: Chen Hsin-Lung , Nouri Babak , Chen Chun-Yu , Huang Yu-Shan , Mansel Bradley 
Published: November 2020

Abstract
The discovery of Frank-Kasper (FK) phase in block copolymer (bcp) has prompted the progress of the field of soft quasicrystals. In principle, the formation of FK phase from the supercooled liquid phase of the bcp micelles should involve the mass transport of constituent molecules to transform the unimodal distribution of micelle size into the multimodal distribution prescribed by the volume asymmetry of the Voronoi cells in the FK phase. Here we present a new regime in which the Laves C14 phase of bcp developed below the glass transition temperature of the micelle core, where the mass transport was inhibited by the immobile block chains forming the core. The bcp micelle comprising a glassy core and a soft corona resembles the fuzzy colloid and the strong van der Waals attraction between the cores directs their organization into C14 phase to minimize the interparticle interaction energy under the metastable condition.
MUC4 mutation correlates with tumor mutation burden and the immune microenvironment in colorectal cancer
Authors: Li Ting , Hui Wenjia , Halike Halina , Gao Feng 
Published: November 2020

Abstract
Background: Immunotherapy is a new strategy for Colorectal cancer (CRC) treatment. Tumor mutation burden (TMB) may act as an emerging biomarker for predicting responses to immunotherapy. Nevertheless, no studies investigate if these gene mutations correlate to TMB and tumor-infiltrating immune cells. Methods: Somatic mutation data for CRC samples were obtained from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) datasets. Then, we investigated the relationship between these mutant genes, TMB and overall survival outcomes. GSEA analysis was performed to explore the underlying mechanism of mutant gene. Finally, we further verified the connection between gene mutations and immune response.Results: We identified 17 common mutant genes shared by both two cohorts. Further analysis found that MUC4 mutation was strongly related to higher TMB and predicted a poorer prognosis. Moreover, functional enrichment analysis of samples with MUC4 mutation revealed that they were involved in regulating the natural killer cell mediated cytotoxicity signaling pathway. Significant changes in the proportion of the immune cells of CD8 T cells, activated NK cells, M1 macrophages and resting memory CD4 T cells were observed using the CIBERSORT algorithm. Conclusions: Our research revealed that MUC4 mutation significantly correlated with increased TMB, a worse prognosis and modulating the immune microenvironment, which may be considered a biomarker to predict the outcome of the immune response in colorectal cancer.
Non-Invasive Plasma Glycomic and Metabolic Biomarkers of Post-treatment Control of HIV
Authors: Giron Leila , Palmer Clovis , Liu Qin , Yin Xiangfan , Papasavvas Emmanouil , Damra Mohammad , Goldman Aaron , Tang Hsin-Yao , Johnston Rowena , Mounzer Karam Mounzer , Kostman Jay , Tebas Pablo , Landay Alan , Montaner Luis , Jacobson Jeffrey , Li Jonathan , Abdel-Mohsen Mohamed 
Published: November 2020

Abstract
Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are urgently needed. Such biomarkers can improve the safety of analytic treatment interruption (ATI) and provide mechanistic insights into the pathways involved in post-ART HIV control. We identified plasma glycomic and metabolic signatures of time-to-viral-rebound and probability-of-viral-rebound using samples from two independent cohorts. These samples include a large number of post-treatment controllers, a rare population demonstrating sustained virologic suppression after ART-cessation. The signatures remained significant after adjusting for key demographic and clinical confounders. We also confirmed a mechanistic link between biomarkers and HIV latency reactivation and myeloid inflammation in vitro. Finally, machine learning algorithms selected sets of biomarkers that predict time-to-viral-rebound with 74–76% capacity and probability-of-viral-rebound with 97.5% capacity. In summary, we fill a major gap in HIV cure research by identifying non-invasive biomarkers, with potential functional significance, that predict duration and probability of viral remission after treatment interruption.