bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Associated with Abnormal Lung Function among University Students, Case of University of Rwanda (UR)
Authors: Leonidas Mvuyekure , Kevin Nwanna , jururyishya Gasana bisetsa 
Published: December 2024

Abstract

Background: Determinants of abnormal lung function among students have not been evaluated. COPD is estimated to have contributed to 3 million deaths worldwide, which is 5% of all fatalities, and over 90% of these deaths occurred in low- and middle-income countries (LMICs), with a global prevalence of 10.3%. A recent study in Rwanda found a COPD prevalence of 4.5%. This study aims to find the “Factors associated with abnormal lung function among university students in Kigali—Rwanda”.
Methods: A Cross-sectional study design and administered questionnaire with a minimum sample size of 220 subjects was used. Spirometry for lung function tests was used to identify abnormalities. A statistical data analysis method was employed by using STATA Version 15.1. Univariate, bivariate, and Chi-square were used. Multivariate logistic regression analysis assessed which independent variable was associated with a dependent variable.
Results: The analysis of this study showed that the high proportion was for female (54.09%). The median age was 23 years (18-29). Regarding marital status all were single. The factors for abnormal lung function were varied and were dominated by building characteristics.The prevalence of abnormal lung function was higher among students (20.9%), almost 4times of the national rate. This prevalence was associated with frequency of window opening (OR:7.06,CI: 1.27-39.30, P=0.025), freshness of air(OR:4.78, CI: 1.76-12.99, P= 0.002) and physical well-being (OR: 4.5; CI: 1.77-11.45, P=0.002).
Conclusion: The prevalence of abnormal lung function showed that it is a problem for public health that needs excellent consideration for the associated factors.
O-GlcNAcylation with ubiquitination stabilizes METTL3, promoting HMGB1 degradation to inhibit ferroptosis and enhance gemcitabine resistance in pancreatic cancer
Authors: Wang qiuhong , Wei Dong , Li Chunman , Yang Xiawei , Su Kun , Wang Tao , Zou Renchao , Wang Lianmin , Cun Dongyun , Tang Bo , Wu Tao 
Published: December 2024

Abstract

Background: Pancreatic cancer is highly lethal, and METTL3 plays a crucial role in m6A regulation. Although ferroptosis is important in cancer therapy, the regulatory mechanism of METTL3 in pancreatic cancer and its potential for regulating ferroptosis as a treatment remain unclear.
Methods: The relationship between METTL3 and gemcitabine resistance and ferroptosis was investigated through in vitro and in vivo functional gain and loss experiments, while the target genes of METTL3 were identified using siRNA and pharmacological inhibitors to analyze the impact of O-GlcNAcylation on METTL3's stability and ubiquitination modification.
Results: We found that O-GlcNAcylation interferes with ubiquitination-mediated regulation of METTL3 stability in pancreatic cancer cells, further clarifying its O-GlcNAcylation site and ubiquitination modification type. METTL3 regulates ferroptosis and Gemcitabine resistance by promoting HMGB1 degradation in a manner dependent on m6A-YTHDF2.
Conclusion: Our study findings clearly demonstrate that METTL3 promotes pancreatic cancer cell proliferation and drug resistance to gemcitabine. This highlights the role of O-GlcNAcylation in stabilizing METTL3 expression and degrading HMGB1 through a m6A-YTHDF2-dependent mechanism, thereby inhibiting ferroptosis in pancreatic cancer cells. Furthermore, targeting HMGB1 while coordinating gemcitabine and RSL3 significantly suppresses pancreatic cancer tumor growth. These results provide valuable insights for the treatment of pancreatic cancer.
A Comparison of Optimization Techniques for Large-scale Allocation of Soybean Crops
Authors: CHEN Mathilde , KATSIRELOS George , MAKOWSKI David , TONDA Alberto 
Published: December 2024

Abstract

The optimal allocation of crops to different parcels of land is a problem of paramount practical importance, not only to improve food and feed production, but also to address the challenges posed by climate change. However, this optimization problem is inherently complex due to the large number of agricultural parcels available which generates a vast search space that renders traditional optimization techniques impractical. Moreover, as maximizing average production may generate solutions characterized by high year-by-year instability and lead to large and unrealistic cultivated areas, it is necessary to optimize crop allocation considering several objectives at the same time. In order to tackle this complex optimization problem, we propose a multi-objective approach, simultaneously maximizing the average production, minimizing the year-on-year production variance, and minimizing the total cultivated surface. The approach exploits an established multiobjective evolutionary algorithm, and employs a machine learning model able to predict crop production from weather and soil conditions, trained on historical data, making it possible to tackle allocation problems of large size. As a reference, we also present a comparison with a quadratic programming algorithm specifically tailored to the target problem. A case study focusing on the allocation of soybean crops in the European continent for the years 2000-2023 shows that the proposed methodology is able to identify informative trade-offs between the conflicting objectives, and identify realistic and meaningful crop allocations for supporting stakeholders’ decisions.
АЛЬФОНСО Х И FECHO DEL IMPERIOВ АМЕРИКАНСКОЙ ИСТОРИОГРАФИИ 1960–1980-х гг.
Authors: Ауров О.В. , Беленький С.Б. 
Published: December 2024

В статье исследованы основные тенденции эволюции интерпретаций образа короля Кастилии и Леона Альфонсо Х Мудрого (1252–1284) и его борьбы за престол Священной Римской Империи (fecho del imperio, 1256–1275) в медиевистике США, от преимущественного внимания к политической истории царствования до акцента на политике Мудрого Короля (Sabio) в области культуры. Изменение исследовательского ракурса связывается с общими условиями становления и развития американской испанистики в ХХ в., влиянием прогресса в изучении истории литературы и языка средневековой Испании на сферу исторических исследований, а также особенностями развития мировой медиевистики в указанный период.
The article deals with the evolution of interpretations of the image of Alfonso X, King of Castile and León (1252-1284) and his struggle for the throne of the Holy Roman Empire (fecho del imperio, 1256-1275) in the American Medieval Studies. These interpretations changed the focus of attention from the political history of the reign to the policy of the Learned King (El Sabio) in the field of culture. This change is explained by different kinds of influences and among them by general conditions of Hispanic Studies’ development in the 20th century, by the progress in the field of studies in Medieval Hispanic philology and linguistics and its influence on the historical studies and by the tendencies of medieval studies in the world during the mentioned period.
ГЕРОЙ ИЗ «ЛЕДЯНОГО ДОМА»: ОБРАЗ А. П. ВОЛЫНСКОГОВ ЛИТЕРАТУРНЫХ ПРОИЗВЕДЕНИЯХ 1820-1830-х гг.
Authors: Крючков Н.Н. 
Published: December 2024

Статья посвящена анализу художественного образа Артемия Волынского в литературных произведениях 20-30-х гг. XIX в. Отсутствие специальных исследований о событиях аннинского царствования, недоступность исторических документов для образованной части общества, влияние романтизма предопределили литературную традицию. Созданный писателем И.И. Лажечниковым идеализированный образ казненного патриота оказался достаточно долговечен.
The paper analyzes a literary representation of Artemy Volynsky in literary works of the 1820s –1830s. The absence of special historical studies of the reign of Anna Ioannovna, the inaccessibility of historical documents for the educated part of society, and the influence of Romanticism predetermined the literary tradition. The idealized image of the executed patriot created by I.I. Lazhechnikov turned out to be rather durable.
ИСТОРИЯ В ВОСПИТАНИИПОДРАСТАЮЩЕГО ПОКОЛЕНИЯ БРИТАНИИ XVIII ВЕКА
Authors: Айзенштат М.П. 
Published: December 2024

История занимала существенное место в социально-политической жизни британцев. В то же время она не была специальным предметом в школах и университетах. На основе изучения переписки графа Честерфилда, У. Питта старшего и Ф. Френсиса в статье анализируется место истории в образовании детей в представлении родителей и опекунов о характере и содержании знаний о прошлом; а также предназначения истории для будущей карьеры.
History occupied an important place in the social and political life of Britons, but it had not been a special subject in schools and Universities. Author analyses the writings of some Whigs: the historical knowledge of their children, what and how they studied; and their views on the utility of history for their future.
ЖЕНСКАЯ ВОЙНА В БЕЛОМ ДОМЕ
Authors: Алентьева Т.В. 
Published: December 2024

В статье рассматривается политический кризис при президенте Эндрю Джексоне, впервые в истории США приведший к отставке всего кабинета министров. «Джексоновская эпоха» была периодом политических инноваций американской демократии. Это – система патронажа, строгой партийной дисциплины, деятельность «кухонного кабинета», назначение на должности по принципу личной преданности. Поводом для политического кризиса послужила так называемая «война юбок», или «женская война» в Белом доме, являвшаяся отражением внутренней политической борьбы в президентском окружении. Она способствовала укреплению позиций проджексоновских сил в администрации и укреплению личной власти президента.
The article describes the political crisis in the United States during the presidency of Andrew Jackson, which for the first time in the history of that country led to the resignation of the entire Cabinet of Ministers. The «Jacksonian era» was a period of political innovation in the American democracy. There were for example: the system of patronage, strict party discipline, the «Kitchen Cabinet» appointed on the basis of personal loyalty. The reason for the political crisis was the so-called «Petticoat affair» in the White house, which was a reflection of the internal political struggle in the presidential environment. It contributed to strengthening the position of the pro-Jacksonian forces in the administration and strengthening the personal power of the President. Keywords: the USA History, 19th century, “the Jacksonian Era”, presidential administration, “the Petticoat affair”
ОЧЕНЬ КРАТКАЯ ИСТОРИЯ ЗАПАДНОЙ “ИДЕОЛОГИИ”Рец. на кн.: Petri R. A Short History of Western Ideology.A critical account. London etc.: Blomsberry, 2018
Authors: Павлов А.В. 
Published: December 2024

Статья представляет собой рецензию на книгу западного историка идей Рольфа Петри, выполненную в жанре «размышления над книгой». Автор не только пересказывает ключевые тезисы Петри относительно истории «западной идеологии», но и пытается концептуализировать за него некоторые идеи, оставшиеся непроясненными из-за обильного цитирования первоисточников.
The article is a review of the monograph by a Western intellectual historian Rolf Petri, made in the genre of “reflections on the book”. The author not only retells Petri’s key theses on the history of "Western ideology", but also tries to conceptualize some ideas that have not been clarified because of the abundant quotations of primary sources.
«ПОНЯТЬ ЧЕЛОВЕКА – САМАЯ ЗАМАНЧИВАЯИ, УВЫ, НЕРАЗРЕШИМАЯ ЗАДАЧА»
Authors: Ивонина Л.И. 
Published: December 2024

Статья представляет собой рецензию на книгу известного российского историка Андрея Соколова «Кларендон и его время. Странная история Эдварда Хайда, канцлера и изгнанника». В ней показаны как достоинства работы, так и ее недостатки, а также отражены дискуссионные моменты.
The article is a review of the book of the famous Russian historian Andrei Sokolov “Clarendon and his time. The Strange Story of Edward Hyde, Chancellor and Exile”. It shows both the advantages of the work, and its shortcomings, and also reflects the discussion points.
СОВРЕМЕННЫЕ ПРАВЫЕ ВО ФРАНЦИИ: КТО ОНИ?
Authors: Канинская Г.Н. 
Published: December 2024

В статье рассматривается монография французского историка Жиля Ришара «История правых во Франции. С 1815 до наших дней». Это фундаментальный труд, законченный автором 5 декабря 2016 г., в момент начавшейся во Франции президентской избирательной кампании, принёсшей в мае 2017 г. ошеломительную победу Э. Мак-рону. В книге дан раскрыта эволюция «политической семьи» французских правых на протяжении четырёх веков. Показано, как трансформировались базовые ценности правых сил и партий, сделана попытка определить, что значит быть правым в XXI в.
The article deals with the monograph of the French historian Gilles Richard “The History of the right-wing forces in France. From 1815 to the present day”. This is a fundamental work completed by the author on December 5, 2016, at the time of the presidential election campaign that began in France, which in May 2017 brought a stunning and to a certain extent unexpected victory to E. Macron. The book presents a historical synthesis of the evolution of the “political family” of the French right-wing forces for four centuries. Against the general background of French and global history shows how to transform the basic values of the right political forces and parties and an attempt to determine what it means to be right in the 21st century.
Application of standard keratometry values obtained from keratotopographic mapping data to calculate the optical power of a multifocal intraocular lens
Authors: Shukhaev S. V. , Boiko E. V. , Petrosyan Yu. M. , Molodkin A. V. 
Published: December 2024

Purpose of the study is to determine the zones of standard keratometry according to keratotopography data, which will allow for more accurate calculation of multifocal IOL using 10 formulas.Material and methods. The study included 55 patients (55 eyes) who underwent phacoemulsification of cataract or refractive lensectomy with femtolaser accompaniment, implantation of multifocal IOL (Acrysof IQ PanOptix) and achieved the target refraction at different distances. Retrospective calculation of the optical power of the IOL was carried out using biometric data from OA-2000 and keratometric indicators of Pentacam (zones from 0.5 mm to 5 mm in increments of 0.5 mm on the Axial/Sagittal map centered on the apex and pupil) using 10 formulas (SRK/T, Holladay 1, Holladay 2, Haigis, Hoffer Q, Barrett 2 Universal, Olsen, Kane, EVO ver. 2.0, Hill RBF ver. 3.0). For each combination of zone/keratometry value/formula, the average error of postoperative predicted refraction, its difference from zero (Wilcoxon criterion), the median value taking into account the sign, the mean (MAE) and median (MedAE) absolute errors in calculating the spherical equivalent of the IOL, the standard deviation of the mean absolute error (SD) were calculated.Results. All formulas had a shift to myopic refraction, except for the Haigis formula, which shifted towards hyperopia. The absence of a significant difference from zero was shown only by the Kane formula in zones 3.5, 4.5–5.0 mm when centered on the apex and in zones 0.5, 1.5, 2.5–5.5 mm when centered on the pupil. The highest values of MAE were found in Haigis and Olsen formulas, and the minimum values were observed in most formulas in the 4.5–5.0 mm zones. The lowest MedAE values in all ranges were shown by the formulas Kane, EVO, Holladay 1 and Holladay 2. The minimum SD values were found for the formulas Kane, EVO, Holladay 1 and Holladay 2.Conclusion. The Kane formula turned out to be the most accurate in the 4.5–5.0 mm zone. This is followed by the EVO 2 and Holladay 1 formulas in the 4.0 mm zone. The Haigis formula turned out to be the least accurate. The remaining formulas can be recommended for use with SimK Pentacam data in 4.0–5.0 mm zones.
Ways to improve the effectiveness of uvulopalatoplasty
Authors: Knyazkov V. B. 
Published: December 2024

Ronchopathy is a complex polyethological disease that has a multifactorial negative effect on the cardiovascular, respiratory and other systems of the body. Mortality in this terrible disease, most often from vascular causes and, especially, in the presence of obstructive sleep apnea syndrome, ranges from 6 to 11%, and the consequences of various complications associated with this disease increase it to 37%. The effectiveness of surgical methods of treating patients with ronchopathy is still clearly unsatisfactory, and does not allow most of them to achieve a guaranteed recovery. At the same time, the growing number of such patients, who are in dire need of effective treatment and reliable prevention of complications of this disease, encourages specialists to further search for surgical treatment methods. Surgical interventions on the soft palate in patients with ronchopathy and obstructive sleep apnea syndrome are based on the principle of injury to the palatine curtain of varying intensity (surgical, thermal, radiofrequency, laser, chemical), independent of the methods of exposure. At the same time, depending on the intensity of exposure, inflammation, necrosis or partial tissue rejection are noted and, as a result, scarring, compaction and a decrease in the volume of the palate. At the same time, the mobility of the palatine curtain should decrease, and the intensity of snoring should decrease. However, injury caused primarily to the velopharyngeal muscles often leads to hypo- and atrophy, hypotension and significant sagging of the palate, and, subsequently, to a recurrence of the disease and increased snoring. This significantly reduces the effectiveness of surgical treatment of these patients. Increasing the effectiveness of uvulopalatoplasty is one of the tasks of modern otorhinolaryngology. Ways to increase the effectiveness of uvulopalatoplasty lie in the following directions: qualitative and adequate selection for the upcoming operation; accurate determination of the level(s) of obstruction, shape and degree of collapse of the soft tissues of the upper respiratory tract; careful consideration of the structural features of the soft palate and pharynx of each individual patient; maximum reduction of surgical trauma to the tissues of the palatine curtain during surgery.
Cardiometabolic Health Intervention Using Music and Exercise (CHIME) Delivered via Telehealth to Wheelchair Users: Protocol for a Randomized Controlled Trial
Authors: Kim Yumi , Rimmer James H , Lai Byron , Oster Robert , Cowan Rachel , Young Hui-Ju , Fisher Gordon , Kim Younguk , Giannone John , Wilroy Jereme D 
Published: December 2024

Background
Wheelchair users live predominantly sedentary lifestyles and have a substantially higher risk for cardiometabolic disease and mortality compared to people without disabilities. Exercise training has been found to be effective in improving cardiometabolic health (CMH) outcomes among people without disabilities, but research on wheelchair users is limited and of poor quality.

Objective
The primary aim of this study is to examine the immediate and sustained effects of a 24-week, telehealth, movement-to-music cardiovascular (M2M-C) exercise program on core indicators of CMH among adult wheelchair users compared to an active control group. The secondary aim is to explore the beneficial effects of M2M-C exercises on cardiovascular capacity, physical activity, and quality of life. Intervention components include tailored exercises and remote performance monitoring, delivered via live videoconference training by a telecoach and asynchronous videos.

Methods
This study’s design is a parallel-arm randomized controlled trial enrolling 132 physically inactive adult wheelchair users with poor cardiometabolic profiles. The M2M-C intervention group involves 24 weeks of virtual live and monitored home exercise training (3×/wk, 15-40 min/session), followed by a 12-week maintenance period where participants have access to an online media library of exercise videos. The control group involves 36 weeks of self-guided exercise through access to a media library of exercise videos, including videos for range of motion, muscle strength, and balance. The primary outcomes are cardiometabolic indicators of health, and assessors are blinded.

Results
Recruitment procedures started in January 2024 with the first participant enrolled on March 18, 2024. All data are anticipated to be collected by November 2027, and the main results of the trial are anticipated to be published by February 2028. Secondary analyses of data will be subsequently published. A total of 16 participants have been recruited as of paper submission.

Conclusions
The knowledge obtained from this trial will provide evidence to inform exercise prescriptions aimed at improving CMH among adult wheelchair users.

Trial Registration
ClinicalTrials.gov NCT05606432; https://clinicaltrials.gov/study/NCT05606432

International Registered Report Identifier (IRRID)
DERR1-10.2196/57423
Muzealizacja kwestionowanego średniowiecznego dziedzictwa. Przykład króla Samuela i bitwy pod Klidion, miasto Petricz w Bułgarii
Authors: Markov Ivaylo , Periklieva Violeta 
Published: December 2024

Artykuł bada skomplikowany proces muzealizacji kontestowanego dziedzictwa w mieście Petricz w Bułgarii ze szczególnym uwzględnieniem postaci króla Samuela i bitwy pod Klidion. Zwiększone znaczenie historyczne przypisywane temu średniowiecznemu królowi i bitwie jest ściśle związane ze złożoną dynamiką kulturową i polityczną po obu stronach granicy bułgarsko-północnomacedońskiej. Nakreślenie podobieństw z sąsiednim regionem Strumicą w Macedonii Północnej umożliwia dogłębną analizę wielu aspektów muzealizacji i odkrywa wzajemne oddziaływanie między narracjami historycznymi, reprezentacją kulturową oraz polityką lokalną i krajową. Podobieństwa te pomagają w kontekstualizacji procesu muzealizacji w Petricz i ujawniają kontrowersyjną naturę konstruowania, ochrony i prezentacji dziedzictwa historycznego. Odnoszone do kwestii budowania tożsamości i negocjowania narracji historycznych są pomocne w analizie motywacji stojących za procesem muzealizacji. Artykuł stanowi wkład w dyskurs naukowy na temat zachowania średniowiecznego dziedzictwa na spornych terytoriach i oferuje wgląd w zawiłe relacje między historią, tożsamością i reprezentacją kulturową.
Violence against memory: communicative strategies of Scythian barrow reuse
Authors: Demina Alisa 
Published: December 2024

This article provides a diachronic analysis of barrow reuse during the Bronze Age and Scythian times, focusing on a case study from the right bank of the Molochna river basin (North Azov, Ukraine). It compares the successive chronological phases of barrow-building cultures from the Yamna to the Scythian time regarding their spatial arrangement, patterns of secondary burial inclusions, and burial reopenings. The spatial analysis shows that all barrow clusters appeared in this territory during the Yamna phase. In all subsequent phases, barrows continued to be constructed exclusively within these pre-existing clusters. Various types of burial inclusions and mound modifications were typical for all Bronze Age phases. However, while Scythian burials maintained the reuse of predecessor’s barrows, they seldom made secondary burials in contemporary barrows. Simultaneously, the number and scale of burial destructions significantly increased during the Scythian time. This shows a shift in attitudes towards barrows within distant and living memory and their role in communicating inheritance claims.