bluuebunny/crossref_metadata_2025_split huggingface dataset:
CircDUSP16 promotes the tumorigenesis and invasion of gastric cancer by sponging miR-145-5p
Authors: Zhang Zizhen , Wang Chaojie , Zhang Yeqian , Yu Site , Zhao Gang , Xu Jia 
Published: November 2019

Abstract
Background
Circular RNAs (circRNAs) as a novel subgroup of non-coding RNAs act a critical role in the pathogenesis of gastric cancer (GC). However, the underlying mechanisms by which hsa_circ_0003855 (circDUSP16) contributes to GC are still undocumented.

Materials
The differentially expressed circRNAs were identified by GEO database. The association of circDUSP16 or miR-145-5p expression with clinicopathological features and prognosis in GC patients was analyzed by FISH and TCGA-seq data set. Loss- and gain-of-function experiments as well as a xenograft tumor model were performed to assess the role of circDUSP16 in GC cells. circDUSP16-specific binding with miR-145-5p was confirmed by bioinformatic analysis, luciferase reporter, and RNA immunoprecipitation assays.

Results
The expression levels of circDUSP16 were markedly increased in GC tissue samples and acted as an independent prognostic factor of poor survival in patients with GC. Knockdown of circDUSP16 repressed the cell viability, colony formation, and invasive potential in vitro and in vivo, but ectopic expression of circDUSP16 reversed these effects. Moreover, circDUSP16 possessed a co-localization with miR-145-5p in the cytoplasm, and acted as a sponge of miR-145-5p, which attenuated circDUSP16-induced tumor-promoting effects and IVNS1ABP expression in GC cells. MiR-145-5p had a negative correlation with circDUSP16 expression and its low expression was associated with poor survival in GC patients.

Conclusions
CircDUSP16 facilitates the tumorigenesis and invasion of GC cells by sponging miR-145-5p, and may provide a novel therapeutic target for GC.
Towards a Better Understanding of Cognitive Deficits in Absence Epilepsy: a Systematic Review and Meta-Analysis
Authors: Fonseca Wald Eric L. A. , Hendriksen Jos G. M. , Drenthen Gerald S. , Kuijk Sander M. J. V. , Aldenkamp Albert P. , Vles Johan S. H. , Vermeulen R. Jeroen , Debeij-van Hall Mariette H. J. A. , Klinkenberg Sylvia 
Published: November 2019

AbstractCognition in absence epilepsy (AE) is generally considered undisturbed. However, reports on cognitive deficits in AE in recent years have suggested otherwise. This review systematically assesses current literature on cognitive performance in children with AE. A systematic literature search was performed in Pubmed, Embase, Cochrane and Web of Science. All studies reporting on cognitive performance in children with AE were considered. In total 33 studies were eligible for inclusion. Neuropsychological tests were classified into the following domains: intelligence; executive function; attention; language; motor & sensory-perceptual examinations; visuoperceptual/visuospatial/visuoconstructional function; memory and learning; achievement. Random-effect meta-analyses were conducted by estimating the pooled mean and/or pooling the mean difference in case-control studies. Full-scale IQ in children with AE was estimated at 96.78 (95%CI:94.46–99.10) across all available studies and in case-control studies IQ was on average 8.03 (95%CI:-10.45- -5.61) lower. Verbal IQ was estimated at 97.98 (95%CI:95.80–100.16) for all studies and 9.01 (95%CI:12.11- -5.90) points lower in case-control studies. Performance IQ was estimated at 97.23 (93.24–101.22) for all available studies and 5.32 (95%CI:-8.27–2.36) points lower in case-control studies. Lower performance was most often reported in executive function (cognitive flexibility, planning, and verbal fluency) and attention (sustained, selective and divided attention). Reports on school difficulties, neurodevelopmental problems, and attentional problems were high. In conclusion, in contrast to common beliefs, lower than average neurocognitive performance was noted in multiple cognitive domains, which may influence academic and psychosocial development.
A survey on data provenance in IoT
Authors: Hu Rui , Yan Zheng , Ding Wenxiu , Yang Laurence T. 
Published: November 2019

AbstractInternet of Things (IoT), as a typical representation of cyberization, enables the interconnection of physical things and the Internet, which provides intelligent and advanced services for industrial production and human lives. However, it also brings new challenges to IoT applications due to heterogeneity, complexity and dynamic nature of IoT. Especially, it is difficult to determine the sources of specified data, which is vulnerable to inserted attacks raised by different parties during data transmission and processing. In order to solve these issues, data provenance is introduced, which records data origins and the history of data generation and processing, thus possible to track the sources and reasons of any problems. Though some related researches have been proposed, the literature still lacks a comprehensive survey on data provenance in IoT. In this paper, we first propose a number of design requirements of data provenance in IoT by analyzing the features of IoT data and applications. Then, we provide a deep-insight review on existing schemes of IoT data provenance and employ the requirements to discuss their pros and cons. Finally, we summarize a number of open issues to direct future research.
Co-created visual narratives and inclusive place branding: a socially responsible approach to residents’ participation and engagement
Authors: Rebelo Cátia , Mehmood Abid , Marsden Terry 
Published: November 2019

AbstractThis paper discusses the importance of co-created visual narratives in developing participatory and inclusive place branding. We refer to the need for a socially responsible approach when considering place branding policies and practices. For this purpose, we develop and empirically apply a novel framework with four interconnected phases comprising place-based contextualization, re-appreciation, re-positioning, and consolidation of residents’ perceptions, experiences and aspirations to develop and initiate inclusive place branding processes. Using participatory research and collaborative visual methods, we worked with a group of residents in Carvalhal de Vermilhas, Portugal. This work stimulated the co-development of collective agency to consider narratives, values and identities to be articulated for creating and promoting more inclusive representation of place in a (hypothetical) branding exercise. The framework application as well as its challenges and limitations, particularly in co-creation processes, were critically deliberated at all phases. Collaborative visual techniques from our analysis emerge as valuable participatory tools for researchers towards improving residents’ participation in place branding, and therefore contributing towards a more inclusive form of this practice. However, we are also aware of the perils associated with communities’ opening up their pristine heritage to touristic ventures, and hence suggest considering the importance of sustainable place-shaping in all branding decisions.
Macro- and Micromechanical Behavior of 316LN Lattice Structures Manufactured by Electron Beam Melting
Authors: Roos Stefan , Botero Carlos , Danvind Jonas , Koptioug Andrei , Rännar Lars-Erik 
Published: November 2019

AbstractThis work focuses on the possibility of processing stainless steel 316LN powder into lightweight structures using electron beam melting and investigates mechanical and microstructural properties in the material of processed components. Lattice structures conforming to ISO13314:2011 were manufactured using varying process parameters. Microstructure was examined using a scanning electron microscope. Compression testing was used to understand the effect of process parameters on the lattice mechanical properties, and nanoindentation was used to determine the material hardness. Lattices manufactured from 316L using EBM show smooth compression characteristics without collapsing layers and shear planes. The material has uniform hardness in strut shear planes, a microstructure resembling that of solid 316LN material but with significantly finer grain size, although slightly coarser sub-grain size. Grains appear to be growing along the lattice struts (e.g., along the heat transfer direction) and not in the build direction. Energy-dispersive x-ray spectroscopy analysis reveals boundary precipitates with increased levels of chromium, molybdenum and silicon. Studies clearly show that the 316LN grains in the material microstructure are elongated along the dominating heat transfer paths, which may or may not coincide with the build direction. Lattices made from a relatively ductile material, like 316LN, are much less susceptible to catastrophic collapse and show an extended range of elastic and plastic deformation. Tests indicate that EBM process for 316LN is stable allowing for both solid and lightweight (lattice) structures.
A hybrid phytoremediation system for contaminants in groundwater
Authors: Martino Louis , Yan Eugene , LaFreniere Lorraine 
Published: November 2019

AbstractImpacted groundwater at hazardous waste release sites often contain mixtures of contaminants. It can be relatively easy to treat some compounds ex situ. However, mixtures of some compounds can be difficult to treat. A method to extract and treat complex mixtures of contaminants of concern using phytotechnology is proposed in this paper. A specific case study is described wherein a hybrid phytoremediation system is compared and contrasted with conventional groundwater and phytoremediation technologies. Nitrate is used as an exemplar co-contaminant since nitrate contamination is (1) widespread in the United States, and (2) difficult and expensive to treat. The approach involves using contaminated groundwater as a source of irrigation water for a phytoremediation grove. Groundwater would be extracted using conventional groundwater extraction methods. Groundwater then would be pumped to multiple irrigation zones under the control of an autonomous irrigation system. Each zone would consist of a number of trees. The root system for each tree would be modified to function as a confined treatment cell that facilitates contaminated water uptake. The irrigation controller would optimize the amount of groundwater that can be extracted and treated while preventing surface water runoff away from the phyto component.
A neural network algorithm for queue length estimation based on the concept of k-leader connected vehicles
Authors: Emami Azadeh , Sarvi Majid , Asadi Bagloee Saeed 
Published: November 2019

AbstractThis paper presents a novel method to estimate queue length at signalised intersections using connected vehicle (CV) data. The proposed queue length estimation method does not depend on any conventional information such as arrival flow rate and parameters pertaining to traffic signal controllers. The model is applicable for real-time applications when there are sufficient training data available to train the estimation model. To this end, we propose the idea of “k-leader CVs” to be able to predict the queue which is propagated after the communication range of dedicated short-range communication (the communication platform used in CV system). The idea ofk-leader CVs could reduce the risk of communication failure which is a serious concern in CV ecosystems. Furthermore, a linear regression model is applied to weigh the importance of input variables to be used in a neural network model. Vissim traffic simulator is employed to train and evaluate the effectiveness and robustness of the model under different travel demand conditions, a varying number of CVs (i.e. CVs’ market penetration rate) as well as various traffic signal control scenarios. As it is expected, when the market penetration rate increases, the accuracy of the model enhances consequently. In a congested traffic condition (saturated flow), the proposed model is more accurate compared to the undersaturated condition with the same market penetration rates. Although the proposed method does not depend on information of the arrival pattern and traffic signal control parameters, the results of the queue length estimation are still comparable with the results of the methods that highly depend on such information. The proposed algorithm is also tested using large size data from a CV test bed (i.e. Australian Integrated Multimodal Ecosystem) currently underway in Melbourne, Australia. The simulation results show that the model can perform well irrespective of the intersection layouts, traffic signal plans and arrival patterns of vehicles. Based on the numerical results, 20% penetration rate of CVs is a critical threshold. For penetration rates below 20%, prediction algorithms fail to produce reliable outcomes.
PUNISHMENT, FORGIVENESS, AND MERCY
Authors: Murphy Jeffrie G. 
Published: November 2019

AbstractForgiveness and mercy are often thought of as acts that we perform or gifts that we bestow. In this essay the author focuses on character and explores the implications for punishment if one focuses on having a character that is merciful and forgiving in disposition. He argues that the tension that is often thought to exist between justice, on the one hand, and forgiveness and mercy, on the other, is lessened by focusing on the virtue of having a forgiving and merciful character.
The positive duty of prevention in the common law and the Convention
Authors: Burin Achas K 
Published: November 2019

AbstractTwenty years after the Human Rights Act 1998 came into force, where are we in our understanding of the relationship between tort and human rights? This paper argues that we are not as far along in our understanding as we could be. The reason for that has been the methodology we used to understand the relationship, focused as it was around remedies, limitation and causation. This paper proposes a new approach, based around the right rather than the remedy. It aims to theorise one particular cause of action – the duty in Osman v United Kingdom – to exemplify this approach. For English lawyers, who have historically used the framework of the forms of action to understand our own law, it is argued that this a good way to comprehend the European jurisprudence.
The “Slovakization” of 19th-Century Migrants from Upper Hungary to the United States: A Case Study in the Politics of Language Use
Authors: O’Donnell Stephen 
Published: November 2019

AbstractUse of the Slovak literary language was central to the Slovak nationalist political movement in the Kingdom of Hungary before 1918. Yet beyond a Slovak nationalist intelligentsia of just 1,000 or so individuals, this idea had little purchase among the claimed nation of two million Slovak-speakers living in “Upper Hungary”—who Slovak nationalists typically understood as lacking sufficient “national consciousness” to support their political aims. As mass, transatlantic migration led to nearly half a million Slovak-speakers leaving Upper Hungary for the United States between 1870 and 1914, these linked issues of language use and “national consciousness” were carried over to the migrant colony. Rather than being a widely held sentiment among migrants from Upper Hungary, this article shows how Slovak national consciousness was generated within the Slovak American community in the final decades of the 19th century. This case study shows how a small group of nationalist leaders consciously promoted literary Slovak as the “print language” of the migrant colony to instill the idea of a common, Slovak nationhood among migrants living on the other side of the Atlantic—a project that helped in turn to create a Slovak national homeland in central Europe after the First World War.
Russian Nationalist Veterans of the Donbas War
Authors: Yudina Natalia , Verkhovsky Alexander 
Published: November 2019

AbstractAmong the Russian citizens who fought in eastern Ukraine on the side of the separatists are representatives of Russian nationalist groups and organizations. After briefly reviewing the details of their participation in the war, this article looks at the various paths open to former militants upon their return from the war. This article identifies such options as continued military training and organization of military camps, participation in the war in Syria, participation in attacks on political opponents in Russia, racially tinged vigilantism, and attempts to return to political activities. Nationalist fighters who have returned from the war found themselves with limited options given the current decline of the radical far-right in Russia. The following three important conclusions can be made: (1) the return of deeply disappointed militants from the Donbas, especially those who had previously participated in radical groups, was perceived as a significant threat, but this threat has not yet materialized; (2) their return had no significant effect on the nationalist movement as a whole; and (3) some groups of former militants nevertheless remain potentially dangerous in the event of political destabilization.
Insight into Western Pacific Circulation from South China Sea Coral Skeletal Radiocarbon
Authors: Hirabayashi Shoko , Yokoyama Yusuke , Suzuki Atsushi , Miyairi Yosuke , Aze Takahiro , Siringan Fernando , Maeda Yasuo 
Published: November 2019

ABSTRACTThe trajectory of the Kuroshio, the western boundary current in the north Pacific, influences regional climate. It intrudes into the South China Sea (SCS) through the Luzon Strait, resulting in the exchange of water, nutrients, heat, and salt between the Pacific and SCS. It has been reported that the trajectory of the Kuroshio has varied with decadal climate changes. However, there has been no report of an observation-based estimate of the variation in the Luzon Strait transport. Here, a 50-year, high-resolution coral skeletal radiocarbon (Δ14C) dataset from 1946 to 1994 is reported from Currimao, northwest of Luzon Island. Δ14C has been used as a sensitive tracer of seawater, and our data indicates a significant increase in Δ14C from 1946 to 1994 related to atmospheric nuclear bomb testing, with more rapid increase in the SCS than in the Pacific. The unusual, rapid Δ14C increase in the 1950s found in our SCS corals together with seasonal variation in Δ14C will helps constrain physical oceanographic models for the western Pacific, including the SCS.
Crude extract of Camellia oleifera pomace ameliorates the progression of non-alcoholic fatty liver disease via decreasing fat accumulation, insulin resistance and inflammation
Authors: Yeh Wan-Ju , Ko Jung , Huang Wen-Chih , Cheng Wei-Yi , Yang Hsin-Yi 
Published: November 2019

AbstractConsumption of a high-fat diet increases fat accumulation and may further lead to inflammation and hepatic injuries. The aim of the study was to investigate the effects of Camellia oleifera seed extract (CSE) on non-alcoholic fatty liver disease (NAFLD). After a 16-week NAFLD-inducing period, rats were assigned to experimental groups fed an NAFLD diet with or without CSE. At the end of the study, we found that consuming CSE decreased the abdominal fat weight and hepatic fat accumulation and modulated circulating adipokine levels. We also found that CSE groups had lower hepatic cytochrome P450 2E1 and transforming growth factor (TGF)-β protein expressions. In addition, we found that CSE consumption may have affected the gut microbiota and reduced toll-like receptor (TLR)-4, myeloid differentiation primary response gene 88, toll/IL-1 receptor domain-containing adaptor-inducing interferon-β (TRIF) expression and proinflammatory cytokine concentrations in the liver. Our results suggest that CSE may alleviate the progression of NAFLD in rats with diet-induced steatosis through reducing fat accumulation and improving lipid metabolism and hepatic inflammation.
Collective criminality and sexual violence: Fixing a failed approach
Authors: SáCouto Susana , Sadat Leila Nadya , Sellers Patricia Viseur 
Published: November 2019

AbstractInternational criminal tribunals have developed a number of legal theories designed to hold individuals responsible for their role in collective criminal conduct. These doctrines of criminal participation, known as modes of liability, are the subject of significant scholarly commentary. Yet missing from much of this debate, particularly as regards the International Criminal Court, has been an analysis of how current doctrine on modes of liability responds to the need to hold collective perpetrators criminally responsible for crimes of sexual and gender-based violence (SGBV). Indeed, many writings in this area of the law address perceived shortcomings in the theoretical underpinnings of modes of liability doctrine in the abstract but ignore the application of this doctrinein concreto. As a result, facially neutral writings on modes of liability may in fact be gendered in application, either because they fail to account for the specific characteristics of sexual and gender-based violence or because they are applied in a manner that requires higher thresholds for finding culpability for the commission of SGBV crimes. This article fills the gap between theory and practice, examining past and present doctrine, and suggesting ways in which the treatment of modes of liability by international criminal courts and tribunals can both properly respond to the need for personal culpability and the dangers of collective criminal activity, particularly as regards SGBV crimes.
Macrolide-resistant Mycoplasma pneumoniae in South Korea: a strong association with M. pneumoniae type 1
Authors: Lee Hye-Young , Choi Sang-Ho , Chang Jeonghyun , Kim Mi-Na , Yu Jinho , Sung Heungsup 
Published: November 2019

Abstract
Mycoplasma pneumoniae is a main pathogen causing community-acquired pneumonia in children and young adults. Since the emergence of macrolide-resistant M. pneumoniae in the early 2000s in Japan, it has been increasingly reported worldwide as a growing problem in treatment for children. With increasing macrolide-resistant M. pneumoniae and limited data regarding its characterization and molecular analysis, we investigated the dominant M. pneumoniae strains during the recent outbreak in South Korea, and evaluated if there was an association between a specific type and macrolide resistance. Between October 2014 and December 2016 in South Korea, 249 respiratory specimens obtained from patients with confirmed M. pneumoniae pneumonia were genotyped the P1 adhesin gene, and the mutations associated with resistance (A2063G and A2064G) were tested by sequencing the targeted domain V regions of the 23S ribosomal RNA gene. Results revealed that M. pneumoniae type 1 were predominant, which was strongly associated with macrolide-resistance during the whole study period. This is the first study assessing whether M. pneumoniae subtype is related to macrolide resistance during the outbreak of M. pneumoniae.
Mixing the stimulus list in bilingual lexical decision turns cognate facilitation effects into mirrored inhibition effects
Authors: Vanlangendonck Flora , Peeters David , Rueschemeyer Shirley-Ann , Dijkstra Ton 
Published: November 2019

AbstractTo test the BIA+ and Multilink models’ accounts of how bilinguals process words with different degrees of cross-linguistic orthographic and semantic overlap, we conducted two experiments manipulating stimulus list composition. Dutch–English late bilinguals performed two English lexical decision tasks including the same set of cognates, interlingual homographs, English control words, and pseudowords. In one task, half of the pseudowords were replaced with Dutch words, requiring a ‘no’ response. This change from pure to mixed language list context was found to turn cognate facilitation effects into inhibition. Relative to control words, larger effects were found for cognate pairs with an increasing cross-linguistic form overlap. Identical cognates produced considerably larger effects than non-identical cognates, supporting their special status in the bilingual lexicon. Response patterns for different item types are accounted for in terms of the items’ lexical representation and their binding to ‘yes’ and ‘no’ responses in pure vs mixed lexical decision.