bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Treatment of Pediatric Posttraumatic Tibiofibular Synostosis by Resection and Peroneal Artery Perforator Adipofascial Flap
Authors: Nemoto Kazuaki , Sakai Noriko , Matsuda Satoshi , Kato Hiroyuki 
Published: November 2019

Case:
Pediatric posttraumatic tibiofibular synostosis (PPTFS) is a rare postfracture complication that often leads to growth abnormalities. There are very few reports demonstrating the long-term efficacy of surgical treatment. An 11-year-old boy with PPTFS displayed progressive prominence of the fibular head and shortening of the lateral malleolus subsequent to a fracture suffered at the age of 5 years. He was treated by synostosis resection and a peroneal artery perforator adipofascial flap. Eight years postoperatively, the synostosis had not recurred, and his earlier growth abnormalities were nearly normal.

Conclusions:
Peroneal artery perforator adipofascial flap is effective for pregrowth spurt PPTFS.
Radiation-Free Management of Lumbar Spine Burst Fractures in Pregnant Women
Authors: R. Nalli Uvaraj , Vaithiyanadhan Singaravadivelu , Govindarajan Hemantha Kumar , Muthu Sathish 
Published: November 2019

Case:
We present the strategies we used in surgical management of delayed presentation of traumatic lumbar fractures with neurological deficits in 2 young primigravida mothers in early trimesters of pregnancy. Posterior stabilization was achieved in a prone position using magnetic resonance imaging (MRI) without radiation.

Conclusions:
Management of spinal cord injury in pregnancy is a delicate scenario in which risks and benefits of surgery have to be explained to the patient for whom surgical management is contemplated. Risk of radiation to the fetus is completely avoided by using MRI perioperatively to assess injury and outcome.
Can ELABELA be a Novel Target in the Treatment of Chronic Lymphocytic Leukaemia?
Authors: Acik Didar Yanardag , Bankir Mehmet , Baylan Filiz Alkan , Aygün Bilal 
Published: November 2019

Abstract
Background: It has been shown that bcl2, bcl-XL and mcl-1 protein levels are high in chronic lymphocytic leukemia cells, and resultantly, apoptosis does not occur chronic lymphocytic leukemia cells. Apelin and apela (ELABELA/ELA/Toddler) are two peptide ligands for a class A G-protein coupled receptor called apelin receptor. Studies have shown that ELA inhibits apoptosis by inhibiting apoptotic proteins and activating anti-apoptotic proteins. Proteins and genes involved in apoptosis are valuable for targeted cancer therapy. We hypothesized that serum levels may be increased in patients with chronic lymphocytic leukemia based on the antiapoptotic effect of ELA. We compared serum apelin levels of healthy volunteers and patients with chronic lymphocytic leukemia. We aimed to draw attention to a new molecule worthy of research in targeted cancer treatment.
Methods: 42 untreated CLL patients and 41 healthy volunteers were included in the study. Serum ELA levels were measured by using enzyme-linked immunosorbent assay kits (Dhanghai Sunred Biological Technology co. Ltd), automated ELISA reader (Thermo Scientific, FİNLAND) and computer program (Scanlt for Multiscan F.C.2.5.1) in accordance with the manufacturer’s instructions. Statistical analysis was done by Statistical Package for Social Sciences for Windows 20 (IBM SPSS Inc., Chicago, IL) ve MedCalc programs. ELA and variables related to CLL were correlated with Spearman correlation anlysis test. ROC analysis and Youden index method were used to determine a cut off point for ELA. All p-values were 2-sided with statistical significance at 0.05 alpha levels.
Results: In our study, we found that serum ELA levels were significantly higher in patients with CLL.
Conclusions: This study highlights that ELA targeting may be a potential therapeutic option for treating CLL.
Keywords: ELABELA; apelinergic system; chronic lymphocytic leukaemia; apoptosis
Level of medication self-management capacity among patients on ambulatory care exiting hospital pharmacy at Muhimbili National hospital, Tanzania: a descriptive cross-sectional study
Authors: Mlyuka Hamu Joseph , Salehe Hija , Mikomangwa Wigilya P , Kilonzi Manase E , Marealle Alphonce I , Mutagonda Ritah F , Bwire George M. 
Published: November 2019

Abstract
Objectives: Medication management capacity of a patient on ambulatory care is direct related to adherence. To our knowledge data on medication management capacity for ambulatory care patients exiting outpatient pharmacy outlets in Tanzania are scarce. This study aimed to determine the level of medication management capacity among patients on ambulatory care exiting Muhimbili National Hospital outpatient pharmacy outlet.
Results: A total of 424 patients on ambulatory care participated in the study. Three hundred eighty seven (91.3%) out of 424 interview questionnaires had complete data and qualified for data analysis. Majority (62.3%) out of 387 study participants had poor medication management capacity; 65.3% out of 387 patients were unable to correctly read the prescription and match the drugs they are carrying. More than half (57.4%) out of 387 participants were unable to correctly take the dose, 73.9% out of 387 were unable to correctly tell the dosing frequency and duration. Only 10.6% out 155 patients with prescription containing drugs with warning or precaution or contraindication or potential side effects were aware.
Intention to Use Long Acting and Permanent Contraceptive Methods and Associated Factors in Health Institutions of Aksum Town, North Ethiopia
Authors: Syum Hailay , Kahsay Gizienesh , Huluf Teklehaymanot , Beyene Berhe , Gerensea Hadgu , Gidey Gebreamlak , Desta Haftom , Abay Mebrahtu , Nuguse Haben , Haile Kebede 
Published: November 2019

Abstract
Abstract
Objective: In Ethiopia, the majority of married women practice predominantly short-acting contraceptive methods. Therefore this study aims to assess intention to use LAPMs and its determinants among short-acting users in Health Institutions of Aksum Town, North Ethiopia.
Results: Prevalence of intention to use LAPMs was 52.1% (95% CI: 47.4-57.0). Good knowledge on LAPMs [AOR=2.15; 95% CI (1.29,3.56)], positive attitude towards LAPMs [AOR=3.41; 95% CI (1.99,5.85)], 18-24 years of age [AOR=3.18; 95% CI (1.30,7.79)], being primary school in educational level [AOR=0.34; 95% CI (0.14,0.78)], decision on the number of children jointly with partner [AOR=2.05; 95% CI (1.01,4.18)], having more than two children [AOR=10.67; 95% CI (1.29,88.31)], and no [AOR=10.21; 95% CI (3.10,33.58)] and one [AOR=4.70; 95% CI (1.68,13.13)] extra number of children desired were factors significantly associated with having intention to use LAPMs compared to their counterparts. The intention to use LAPMs was low. Therefore, appropriate information, education and communication strategies must be designed to raise awareness and change the negative attitude of the community on LAPMs.
Keywords: LAPMs, intention to use, factors, Axum, Ethiopia
Developing a High-Performance Liquid Chromatography Fast and Accurate Method for Quantification of Silibinin
Authors: Bakhshi Faezeh , Molavi Ommoleila , Rashidi Mohammad Reza , Shayanfar Ali , Amini Hassan 
Published: November 2019

Abstract
Objective : Silibinin is an antioxidant agent and is shown to have anticancer effects in different cancers including lung, breast, colorectal, liver, prostate, and kidney. There are challenges in the clinical use of silibinin. The main limitation is low solubility, poor oral absorption, and extensive hepatic metabolism. We aim to develop a High-Performance Liquid Chromatography (HPLC) sensitive method for quantification of silibinin in aqueous samples to quantify its concentration in new formulations. A reverse-phase high-performance liquid chromatography (RP-HPLC) composed of C18 column as stationary phase and the mixture of methanol (90%) and water (10%) as mobile phase. The developed method was validated based on the established guidelines.
Results : The retention time for silibinin was seen in 2.97 minute after injection. The calibration curve was drawn and the established method demonstrated a linear ranged from 10 to 100 µg/ml, with a correlation coefficient of 0.996. The sensitivity of the developed method was 10 µg/ml. The accuracy calculated in the range of 88-105.9% and the precision (as relative standard deviation) was between 2.7-10.9%. These results demonstrate that the developed method can be a fast and accurate method for quantification of silibinin in aqueous samples.
Real-world data of eribulin in advanced and pretreated HER2-negative breast cancer in a Spanish comprehensive cancer center
Authors: Sirvén Milana Bergamino , Fernández-Ortega Adela , Stradella Agostina , Morilla Idoia , Falo Catalina , Vázquez Silvia , Castany Roser , Villanueva Rafael , Recalde Sabela , Pérez Valentí Navarro , Gil-Gil Miguel , Pernas Sonia 
Published: November 2019

Abstract
Background

Eribulin improves survival in pre-treated HER2-negative advanced breast cancer (ABC). However, limited data exist on co-morbidities and central nervous system (CNS) efficacy. The purpose of this study was to review eribulin’s efficacy and safety in everyday clinical practice with special focus on age, body mass index (BMI) and central nervous system (CNS) activity.Methods

An observational study was conducted in a series of HER2-negative ABC patients treated from January’14-December’17 outside a clinical trial. Objective Response Rate (ORR), Progression Free Survival (PFS), Overall Survival (OS), and association of clinical and pathological variables with outcome were evaluated.Results

Ninety-five women were treated with at least one cycle of eribulin. Median age was 57 (33-83), and 18% were obese. Median number of prior chemotherapies for ABC was 3 (2-5) and 76% of patients had visceral metastases, including 21% with CNS involvement. Most tumors were estrogen receptor-positive (79%). ORR and stable disease (SD) at 6 months were 26.2% and 37.5%, respectively. Remarkably, relevant CNS efficacy was observed with eribulin: 20% of patients obtained partial response and 25% SD. Treatment was generally well tolerated and manageable, with 29% grade 3 and 10.9% grade 4 toxicities. Median PFS and OS were 4.1 months (CI95% 3.2-4.9) and 11.1 months (CI95% 9.5-14.7), respectively. Triple-negative disease, >2organs involved and being younger than 70 years old were independent prognosis factors for worse OS in multivariate analysis. Most patients (75%) progressed in pre-existing metastases sites.Conclusions

In everyday clinical practice, eribulin’s efficacy seems similar to pivotal trials. CNS-efficacy was observed. TNBC, >2 organs involved and being younger than 70 years old were independent prognosis factors for worse OS. Remarkably, less incidence of grade 4-toxicity compared to previous studies was found.
Basic Characterization of Plant Actin Depolymerizing Factors: A Simplified, Streamlined Guide
Authors: Sengupta Sonali , Rajasekaran Kanniah , Baisakh Niranjan 
Published: November 2019

Abstract
Actin depolymerizing factors (ADFs) are small monomeric actin-binding proteins that alter the oligomeric state of cellular actin. Members of the ADF family can bind both the G-actin and F-actin in plants, and their functions are regulated by cellular pH, ionic strength and availability of other binding partners. Actin depolymerization activity is reportedly essential for plant viability. By binding to the ADP-bound form of actin, ADFs severe actin filaments and thereby provide more barbed filament ends for polymerization. They also increase the rate of dissociation of F-actin monomer by changing the helical twist of the actin filament. These two activities together make ADF the major regulator of actin dynamics in plant cell. Therefore, it is essential to measure the binding and depolymerization activity of the plant ADFs. Here, we present a simplified, streamlined step-by-step protocol to quickly measure these important functions of the ADF proteins in vitro.
Protective effects of salvianolate on myocardial injury or myocardial infarction after elective percutaneous coronary intervention in NSTE-ACS patients: a randomized placebo-controlled trial
Authors: Ou Yang , Sun Shengjia , Shi Haiming , Luo Jianfeng , Luo Xinping , Shen YunZhi , Chen Yufei , Zhu Zhidong , Liu Xiaojin , Fan Weihu , Shen Wei 
Published: November 2019

Abstract
Percutaneous coronary intervention (PCI) can cause myocardial injury or myocardial infarction. There is unmet need to reduce incidence or severity of PCI related myocardial injury or myocardial infarction. This study is to evaluate the protective effects of salvianolate on PCI related myocardial injury or myocardial infarction after elective PCI in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients. Methods We enrolled patients with NSTE-ACS who underwent elective PCI. The patients were randomly assigned to the salvianolate group or the control group. The incidence and the severity of PCI related myocardial injury or myocardial infarction, in addition to major adverse cardiac events (MACEs) during one year follow-up after PCI were studied between the two groups. We also performed a multivariate logistic regression analysis to determine the independent factors for PCI related myocardial injury or myocardial infarction after elective PCI. Results Compared with the control group, salvianolate treatment reduced the incidence of PCI related severe myocardial injury or myocardial infarction (11.7% vs 26.5%, p = 0.035). The rate of MACEs or all-cause death within one month or one year after the procedure was not significantly different between the two groups. Conclusions Periprocedural treatment with salvianolate reduces the incidence of PCI related severe myocardial injury or myocardial infarction, although it does not influence clinical prognosis.
Barriers and facilitators to retaining a cohort of street-based cisgender female sex workers recruited in Baltimore, Maryland, USA: Results from the SAPPHIRE study
Authors: Silberzahn Bradley , Morris Miles B. , Riegger Katelyn E. , White Rebecca H. , Tomko Catherine A. , Park Ju N. , Footer Katherine H.A. , Huettner Steven S. , Sherman Susan G. 
Published: November 2019

Abstract
Background: Despite experiencing HIV/STIs, violence, and other morbidities at higher rates than the general public, street-based female sex workers are often absent from public health research and surveillance due to the difficulty and high costs associated with engagement and retention. The current study builds on existing literature by examining barriers and facilitators of retaining a street-based cohort of cisgender female sex workers recruited in a mobile setting in Baltimore, Maryland who participated in the SAPPHIRE study. Participants completed interviews and sexual health testing at baseline, 3-, 6-, 9-, and 12-months.
Methods: Retention strategies are described and discussed in light of their benefits and challenges. We also calculated analyzed raw and adjusted retention proportions at each follow-up period. Lastly, baseline sample characteristics were compared by number of completed visits across demographic, structural vulnerabilities, work environment, and substance use variables using F-tests and Pearson’s chi-square tests.
Results: Although there were drawbacks to each retention strategy, each method was useful in tandem in achieving a successful follow-up rate. While direct forms of contact such as phone calls, social media outreach, and email were useful for retaining more stable participants, less stable participants required extensive field-based efforts such as home and site visits that increase the likelihood of random encounters. Overall, adjusted retention exceeded 70% for the duration of the 12-month study. Participants who were younger, recently experienced homelessness, and injected drugs daily were less likely to have completed all or most follow-up visits.
Conclusion: Retention of street-based female sex workers required the simultaneous use of diverse retention strategies that were tailored to participant characteristics. With familiarity of the dynamic nature of the study population characteristics, resources can be appropriately allocated to the most likely method(s) of successful retention.
Establishing a protocol for the selection of zircon inclusions in garnet for Raman thermobarometry
Authors: Campomenosi Nicola , Rubatto Daniela , Hermann Joerg , Mihailova Boriana , Scambelluri Marco , Alvaro Matteo 
Published: November 2019

AbstractThe structural and chemical properties of zircon inclusions in garnet megablasts from the Dora Maira Massif (Western Alps, Italy) were characterized in detail using charge contrast imaging, Raman spectroscopy, and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The aim of this work is to determine to what extent the degree of metamictization, metamorphic recrystallization, inherent structural heterogeneity, chemical composition, and zoning, along with the elastic stress imposed by the host mineral, can influence the Raman peak position of the zircon inclusion and hence, the residual pressure estimated via Raman geo-thermobarometry. We show and confirm that metamictization and inherent structural heterogeneity have a major influence in the Raman spectra of zircon in terms of peak position and peak width. We suggest that, for spectral resolution of 2 cm−1, the peak width of the B1g mode near 1008 cm−1 of reliable grains must be smaller than 5 cm−1. The method can be applied to both inherited igneous and newly formed Alpine metamorphic crystals. By coupling structural and chemical information, we demonstrate that there are no significant differences between the Raman spectra of zircon with oscillatory-zoned texture, formed during magmatic crystallization, and those formed by fluid-induced Alpine (re)crystallization. The discrimination between magmatic and metamorphic zircon based only on micro-textural constraints is not robust. Finally, our results allow establishing a protocol devoted to the selection of reliable buried zircon inclusions, relying only on Raman spectroscopic measurements, to use for elastic thermobarometry applications.
Application of blood plasma enriched with platelet derived growth factors in experimental perforation of the tympanic membrane
Authors: Gurov A. V. , El’chaninov A. V. , Murzakhanova Z. V. 
Published: November 2019

Acute traumatic perforation of the tympanic membrane occupies a significant place in the structure of the pathology of the middle ear, since «persistent» perforation of the tympanic membrane is the main cause of chronic inflammation in the middle ear, leading to hearing loss and reducing the quality of life of patients. «Persistent» perforation of the tympanic membrane, according to various authors, is formed in 84-392 cases per 10,000 population, so restoring the integrity of the damaged tympanic membrane is one of the main tasks of reconstructive otosurgery. Most authors are of the opinion that it is advisable to close the traumatic eardrum defect early. To date, many ways to close it have been developed. In modern otorhinolaryngology there is extensive experience in using various methods of myringoplasty using various materials for traumatic perforation of the tympanic membrane. However, such a wide variety of plastic techniques and the variety of materials used for this indicates an unresolved problem of closing the perforation of the tympanic membrane. To date, many works have been published that confirm the effectiveness of the use of blood plasma enriched with platelet growth factors in plastic surgery, cosmetology, traumatology, and dentistry. The result of exposure to blood plasma enriched with growth factors is the expression of proteins that regulate chemotaxis, adhesion, cell proliferation, angiogenesis, cell differentiation and the synthesis of extracellular matrix components. Blood plasma enriched with growth factors is autologous (biocompatible), safe from the point of view of the transfer of infectious pathogens. Thus, it can be assumed that the use of plasma enriched with growth factors during surgery during closure of acute perforation of the tympanic membrane will lead to accelerated tissue regeneration and, consequently, a reduction in the length of the postoperative period, and improved treatment outcomes. The use of this method is possible even in a day hospital.
A modern approach to the comprehensive treatment of allergic rhinitis
Authors: Karpishchenko S. A. , Lavrenova G. V. , Mil’chakova A. S. 
Published: November 2019

The problem of allergic rhinosinusopathies is one of the most pressing in modern rhinology. It has drawn the attention of clinicians for several decades. Allergic rhinitis is a common disease, the onset of which often come in early childhood. In later life, this disease significantly reduces the quality of life. The widespread prevalence of allergic rhinitis among children and able-bodied adults, growing incidence rates of the disease represent a significant medical and social problem. Allergic rhinitis should be treated by otorhinolaryngologists and allergists-immunologists. Given the pathogenetic mechanisms of the disease, it is necessary to act upon the local symptoms and total body. Extension of disease remissions, teaching patients the principles of elimination therapy and how to maintain a healthy microclimate at home, relapse prevention are the main directions in the treatment of allergic rhinitis. The primary task of otorhinolaryngologists and allergists-immunologists is to restore unlabored nasal breathing in such patients. Symptomatic therapy includes administration of vasoconstrictor drugs, anticholinergics, cromons, local and systemic antihistamines, leukotriene receptor blockers, topical and systemic glucocorticosteroids (GCS), sorbents, pre- and probiotics. Despite the fact that the symptomatic therapy methods cannot provide a long-lasting effect after cancellation, local symptomatic treatment of allergic rhinitis using topical corticosteroids is generally accepted and widely used in the otorhinolaryngology practice. Flixonase is one of the topical corticosteroids that are often prescribed for allergic rhinitis. The aim of our paper was to evaluate the effectiveness of the treatment regimen of allergic rhinitis using Flixonase as a local GCS. 24 people with perennial allergic rhinitis aged from 19 to 38 years were under our observation. The following therapy was prescribed to the patients: decongestants, rinsing the nasal cavity with saline (saltwater) solutions, corticosteroids (Flixonase), mild sedatives. Flixonase showed its efficacy in our study.