bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risks Of Ventilator-Associated Pneumonia And Invasive Pulmonary Aspergillosis In Patients With Viral Acute Respiratory Distress Syndrome Related or Not To Coronavirus 19 Disease
Authors: Razazi Keyvan , ARRESTIER Romain , Haudebourg Anne-Fleur , Benelli Brice , Carteaux Guillaume , Decousser Jean-Winoc , Fourati Slim , Woerther Paul-Louis , Schlemmer Frederic , Charles-Nelson Anais , Botterel Françoise , Prost Nicolas De , Mekontso-Dessap Armand 
Published: July 2020

Abstract
Background The goal of this study was to assess risk factors of ventilator-associated pneumonia (VAP) and invasive pulmonary aspergillosis in patients with SARS-CoV-2 infection.Methods. We conducted a monocenter retrospective study comparing the prevalence of VAP and invasive aspergillosis between patients with COVID-19 related acute respiratory distress syndrome (C-ARDS) and those with non-SARS-CoV-2 viral ARDS (NC-ARDS).Results. We assessed 90 C-ARDS and 82 NC-ARDS patients, who were mechanically ventilated for more than 48 hours. At ICU admission, there were significantly fewer bacterial coinfections documented in C-ARDS than in NC-ARDS: 14 (16%) vs 38 (48%), p<0.01. Conversely, significantly more patients developed at least one VAP episode in C-ARDS as compared with NC-ARDS : 58 (64%) vs. 36 (44%), p=0.007. The probability of VAP was significantly higher in C-ARDS after adjusting on death and ventilator weaning [sub-hazard ratio = 1.72 (1.14-2.52), p<0.01].The prevalence of multi-drug resistant bacteria (MDR) related VAP was significantly higher in C-ARDS than in NC-ARDS: 21 (23%) vs. 9 (11%), p=0.03. Carbapenem was more used in C-ARDS than in NC-ARDS: 48 (53%), vs 21 (26%), p<0.01. According to AspICU algorithm, there were fewer cases of putative aspergillosis in C-ARDS than in NC-ARDS [2 (2%) vs. 12 (15%), p=0.003], but there was no difference in Aspergillus colonization.Conclusions. In this retrospective case-control study, we evidenced a higher prevalence of VAP and MDR-VAP in C-ARDS than in NC-ARDS, and a lower risk for invasive aspergillosis in the former group.
High Frequency of 45,X/46,XY mosaicism carring a structurally abnormal Y chromosome in patients with Y chromosome microdeletions: a 8-year period retrospective study
Authors: Li Hong-Ge 
Published: July 2020

Abstract
Background: Structural abnormalities of Y chromosome are commonly described in associated with the occurrence of a 45,X/46,XY chromosomal mosaicism. In recent years, evidences of an association between Y chromosome microdeletions and 45,X/46,XY mosaicism had been investigated, and 45,X/46,XY mosaicism was found to be particularly common in patients with Y chromosome microdeletions. The aim of our study was to investigate the presence of 45,X/46,XY mosaicism carrying a structurally abnormal Y chromosome in patients with Y chromosome microdeletions.Results: A 8-year retrospective study was conducted on 6545 infertile men with nonobstructive azoospermia or oligozoospermia. A total of 19 patients with 45,X/46,XY mosaicism or its variants were found, of which 78.95% (15/19) had a structural Y chromosome abnormalities in 46,XY cell line. Thirteen of 19 (68.42%, 13/19) patients with 45,X/46,XY mosaicism had Y chromosome microdeletions, and 12/13 (92.31%) of them exhibited a structurally abnormal Y chromosome.Conclusions: Our results were consistent with previous studies that a high frequency of 45,X/46,XY mosaicism or its variants were detected in patients with Y chromosome microdeletions. Different from previous studies, we found that 45,X/46,XY mosaicism in patients with Y chromosome microdeletions almost all exhibited a structurally abnormal Y chromosome.
The deadly “bulging balloon” within the mediastinum: a case of a giant aortic root aneurysm in a young patient with Marfan syndrome
Authors: SHEN JIAYU , Gan Changping , Rajaguru R.D.T. , Yuan Dou , XIAO ZHENGHUA 
Published: July 2020

Abstract
Introduction:
Marfan syndrome (MFS) is a common heritable connective tissue disease involving multiple organs. Even though the clinical manifestations of MFS can be various, aortic root aneurysm is estimated as one of the most serious complications. We herein describe an individualized treatment decision-making process for a 23-year-old male with MFS, suffering from a giant but stable aortic root aneurysm which is extremely rare at his age.
Case:
The patient, a 23-year-old male with a family history of MFS, presented to our cardiovascular department because of progressive exertional chest distress, fatigue and occasional precordial pain. Physical examinations revealed six-foot-three inches of height, high myopia, and a diastolic murmur at the aortic valve area. Laboratory examinations for systemic vasculitis and infectious diseases were negative. The transthoracic echocardiography (TTE) and enhanced thoracic computed tomography (CT) scan revealed the existence of a giant aortic root aneurysm (125.1 mm in short-axis), severe aortic valve regurgitation, cardiac dilatation (LV; 99 mm in diastolic diameter) and a poor ejection fraction (EF; 18%). Considering the risk of rupture or dissection of the dilated aortic root, we successfully performed the Bentall procedure based on the intraoperative exploration results. Postoperative thoracic CT scan revealed a normal sized reconstructed aortic root, and the patient was discharged uneventfully 7 days later.
Conclusion
It is extremely rare to report such a giant aortic root aneurysm in a young patient. In the treatment decision-making process, the patient’s specific situation should be taken into consideration. The composite replacement of the aortic valve and ascending aorta should be performed if the patient is not suitable for valve-sparing operation.
Chemical Diversity of Essential Oils from Pinus Nigra Arn. Subspecies Growing in Tunisia
Authors: Fkiri Sondes , Mezni Faten , Khouja Mohamed Larbi , Nasr Zouheir , Khaldi Abdelhamid 
Published: July 2020

Abstract
Background: The aim of this study was the determination of chemical diversity of Pinus nigra Arn essential oils. The work was conducted on needles collected from eighteen provenances of Black pine grown in common garden located in West-Northern Tunisia and belonging to four different subspecies (P. nigra subsp. nigra, P. nigra subsp. salzmannii, P. nigra subsp. pallasiana and P. nigra subsp. laricio). The GC analysis was carried out with a Gas Chromatograph coupled to a mass spectrometry. Results: Oil yields ranged from 0.19% to 0.68%. Twenty-three constituents accounting about 98% of total oil composition were identified. The essential oil compositions appeared to be very different in the different provenances. There appear to be five basic essential oil chemotypes in P. nigra plants investigated: caryophllene oxide, camphene, β caryophyllene, α amorphene and Germacrene D. Oils from nigra subsp. were the richest in α-pinene.Conclusions: this study showed that the analyzed oils belonged to five different chemotypes. Caryophyllene oxide was the main component of almost studied oils.
Participatory Forestry Improves Mangrove Forest Management in Kenya
Authors: Kairu Anne , Kotut Kiplagat , Mbeche Robert , Kairo James Gitundu 
Published: July 2020

Abstract
Background: Mangrove forests worldwide are highly valued for their social, ecological and environmental roles. Participatory forestry has been recognized as a tool for improvement of forest conditions. The current study assessed impacts of PFM implementation on structure and regeneration of mangroves at Gazi Bay, Kenya. Forest data was collected along belt transects perpendicular to waterline in both community and state managed blocks. Results: Basal area and standing density were significantly higher in the co-managed forests (16 m2 ha-1 and 4,341 tree ha-1) as compared to the state managed forests (eastern block 10.3 m2 ha-1 and 2,673 trees ha-1; western block 6.2 m2 ha-1 and 2,436 trees ha-1). There were significantly higher (p = 0.0068) densities of quality class poles in co-managed forest block as compared to state-managed eastern and western blocks. Natural regeneration values of 38,822 juveniles ha-1 in the co-managed central block and 23,556 and 35,061 juveniles ha-1 in the state managed eastern and western blocks respectively are considered adequate to support recovery of the forest. A higher complexity index (CI) recorded in the co-managed mangrove forest compared to the state managed eastern and western blocks is particularly due to improved stand density, tree height, and biomass resulting from increased surveillance and protection by the community. The results have wide implications in the management of mangroves for community and biodiversity benefits and climate change mitigation.Conclusion: The results support community participation for improved management of mangrove forests and are in conformity with sectoral policies on natural resources management in Kenya.
The Relationship Between Seasonality, Latitude and Tuberculosis Notifications in Pakistan
Authors: Butt Mohsin F. , Younis Sidra , Wu Zhenqiang , Hadi Syed H. , Latif Abdullah , Martineau Adrian R. 
Published: July 2020

Abstract
BackgroundPakistan is amongst the top 20 highest burden tuberculosis (TB) countries in the world. Approximately 369,548 cases of TB (all forms) were notified in 2018, with an estimated incidence of 265 per 100,000 people per year. In other settings, TB has been shown to demonstrate seasonal variation, with higher incidence in the spring/summer months and lower incidence in the autumn/winter; the amplitude of seasonal variation has also been reported to be higher with increasing distance from the equator.MethodsNotifications of newly-diagnosed pulmonary and extrapulmonary TB cases were obtained for 139 districts in Pakistan from 2011–2017. Data were provided by the Pakistan National TB Control Programme, Islamabad, Pakistan. Statistical analyses were performed to determine whether there was seasonal variation in TB notifications in Pakistan; whether the amplitude of seasonal variation in TB notifications varied according to latitude; whether the amplitude of seasonal variation of TB in Pakistan differed between extrapulmonary TB vs. pulmonary TB. To assess the quarterly seasonality of TB, we used the X-13-ARIMA-SEATS seasonal adjustment programme from the United States Census Bureau. The mean difference and corresponding 95% confidence intervals of seasonal amplitudes between different latitudes and type of TB were estimated using linear regression.ResultsTB notifications were highest in quarter 2, and lowest in quarter 4. The mean amplitude of seasonal variation was 25.5% (95% CI 25.0–25.9%). The mean seasonal amplitude of TB notifications from latitude 24.5ºN-<26.5ºN was 29.5% (95% CI 29.3–29.7%) whilst the mean seasonal amplitude of TB notifications from latitude 34.5ºN -<36.5ºN was 21.7% (95% CI 19.6–23.9%). The mean seasonal amplitude of TB notifications across Pakistan between latitudes 24.5ºN to 36.5ºN reached statistically significant difference (p < 0.001). The amplitude of seasonal variation was greater for extrapulmonary TB (mean seasonal amplitude: 21.6%, 95% CI 32.1–33.1%) vs. smear positive pulmonary TB (mean seasonal amplitude 32.6%, 95% CI 21.4–21.8%), p < 0.001.ConclusionTB notifications in Pakistan exhibit seasonal variation with a peak in quarter 2 (April-June) and trough in quarter 4 (October-December). The amplitude of seasonality decreases with increasing latitude, and is more pronounced for extrapulmonary TB than for pulmonary TB.
Comparison of the Reduction of LDL-C or nonHDL-C induced by Red Yeast Rice Extract, Xuezhikang, between Fasting and Postprandial States in Patients with Coronary Artery Disease
Authors: Zhu Li-Yuan , Wen Xing-Yu , Xiang Qun-Yan , Guo Li-Ling , Xu Jin , Zhao Shui-Ping , Liu Ling 
Published: July 2020

Abstract
Background: Xuezhikang, an extract of red yeast rice, effectively lowers fasting and postprandial triglyceride (TG) levels. It was unknown that whether Xuezhikang could contribute the lipid management goals, low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (nonHDL-C) at fasting and postprandial states in patients with coronary artery disease (CAD).Methods: Fifty CAD patients were divided into Xuezhikang (XZK, n=25) group and control (CON, n=25) group randomly to receive red yeast rice exact, 1200mg/d Xuezhikang capsules or not for 6 weeks (6w). Blood lipids were detected repeatedly before and after 6w at 0, 2, 4 and 6 hours (h) after a standard breakfast with 800kcal.Result: When taking all patients as a whole (n=50), serum LDL-C level decreased while TG and RC levels increased significantly at 2, 4 and 6 h after breakfast (P＜0.05). Serum nonHDL-C level mildly but significantly increased at 4h and 6h after breakfast (P＜0.05). Short-term Xuezhikang treatment decreased tAUCs of TC, TG, LDL-C, nonHDL-C and RC whereas increased that of HDL-C significantly (P＜0.05). Serum LDL-C level showed a drop of 27.8%, 28.1%, 26.2%, 25.3% at 0, 2, 4 and 6 h, respectively, after breakfast. Serum nonHDL-C level showed a drop of 27.6%, 28.7%, 29.0% and 28.0% at 0, 2, 4 and 6 h, respectively. There was no significant difference in the percentages of reduction in LDL-C or nonHDL-C level among four time-points.Conclusions: Xuezhikang significantly decreased LDL-C or nonHDL-C level with similar percentages of reduction between fasting and postprandial states in patients with CAD, indicating that postprandial blood lipids detected at the same time point after a daily meal could replace fasting blood lipids to evaluate the efficacy of cholesterol-lowering therapy in CAD patients, unwilling or unable to keep a fasting state.
Bone erosions detected by ultrasound are prognostic for clinical arthritis development in patients with ACPA and musculoskeletal pain
Authors: Ziegelasch Michael , Eloff Emma , Hammer Hilde Berner , Cedergren Jan , Martinsson Klara , Reckner Åsa , Skogh Thomas , Magnusson Mattias , Kastbom Alf 
Published: July 2020

Abstract
BackgroundTo assess the prognostic value of ultrasound for clinical arthritis development among anti-citrullinated peptide antibody (ACPA)-positive patients with musculoskeletal (MSK) pain.MethodsWe prospectively followed 82 ACPA-positive patients with MSK pain without clinical signs of arthritis at baseline. Ultrasound examination at baseline assessed synovial hypertrophy (SH), and inflammatory activity by power Doppler (PD) in 36 small joints and 6 tendons, and erosions in 18 joints. We applied Cox regression analyses to examine associations with clinical arthritis development during follow-up (median, 69 months; range, 24–90 months). We also compared the ultrasound findings among the patients to a control group of 100 blood donors without MSK pain.ResultsClinical arthritis developed in 39/82 patients (48%) after a median of 6 months (range, 1–71 months). One or more ultrasound erosions occurred in 13/82 patients (16%), with none in control subjects (p < 0.001). Clinical arthritis development was more common among patients with baseline ultrasound erosions than those without (77% vs 42%, p = 0.032), and remained significant in a multivariable Cox regression analysis that included previously described prognostic factors (HR 3.9, 95% CI 1.6–9.4, p = 0.003). Ultrasound-detected tenosynovitis was more frequent among the patients and associated with clinical arthritis development in a univariable analysis (HR 2.5, 95% CI 1.1–5.7, p = 0.031), but did not remain statistically significant in multivariable analysis. Neither SH nor PD was associated with arthritis development.ConclusionsBone erosions detected by ultrasound are independent predictors of clinical arthritis development in an ACPA-positive at-risk population.Trial registrationRegional Ethics Committee in Linköping, Sweden, Dnr M220-09. Registered 16 December 2009, https://etikprovningsmyndigheten.se/
Arthroscopic Reconstruction of Anterior Cruciate Ligaments With Allograft: Single-tunnel Double-bundle Versus Single-tunnel Single-bundle
Authors: Zhu Weimin , Zhou Yuanhui , Chen Kang , Zheng Yizi , Lu Wei , Wang Daping , Zeng Yanjun , Deng Zhenhan , Xiong Jianyi 
Published: July 2020

Abstract
Purpose

Arthroscopic reconstruction of anterior cruciate ligament (ACL) commonly adopted single-tunnel single-bundle (STSB) or double-tunnel double-bundle (DTDB) methods. Though single-tunnel double-bundle (STDB) has been used in clinical practice, the efficacy remains unclear. The objective of this study is to compare the clinical results of ACL reconstruction using the STDB and STSB techniques.
Methods

Between March 2010 to June 2013, 78 patients with ACL rupture underwent arthroscopic STDB reconstruction (42 cases) or STSB reconstruction (36 cases) using anterior tibialis tendon allografts in our department. IKDC, Lysholm and Tegner scores were used to evaluate the subjective function of the knee joint during the postoperative follow-up. In addition, the Lachman test and pivot shift test were used to objectively assess the stability of the knee.
Results

The average follow-up time is 24.2 ± 5.7 months in the STDB group, and 24.8 ± 6.6 months in the STSB group. Patients in both groups recovered to preoperative sports level with few complications. The postoperative Lysholm, IKDC, Tegner scores, and knee joint stability were significantly improved compared to preoperative status in both groups (P < 0.05). However, no statistically significant difference was observed between the two groups at the final follow-up (P > 0.05), except for the improvement of pivot shift test positive rate in the STDB group compared with STSB group (P < 0.05).
Conclusion

Both techniques can be used to restore the stability and function of the knee joint with satisfactory short-term efficacy, and STDB showed better rotational stability than STSB technique, indicating the STDB technique may also considered a reliable method for ACL reconstruction.
Innovative Strategies For Providing Menstruation-Supportive Water, Sanitation And Hygiene (Wash) Facilities: Learning From Refugee Camps In Cox’s Bazar, Bangladesh
Authors: Schmitt Margaret L , Wood Olivia R. , Clatworthy David , Rashid Sabina Faiz , Sommer Marni 
Published: July 2020

Abstract
Background: There is growing attention to addressing the menstrual hygiene management (MHM) needs of the over 21 million displaced adolescent girls and women globally. Current approaches to MHM-related humanitarian programming often prioritize the provision of menstrual materials and information. However, a critical component of an MHM response includes the construction and maintenance of water, sanitation and hygiene (WASH) facilities, including more female-friendly toilets. This enables spaces for menstruating girls and women to change, dispose, wash and dry menstrual materials; all of which are integral tasks required for MHM. A global assessment identified a number of innovations focused on designing and implementing menstruation-supportive WASH facilities in the refugee camps located in Cox’s Bazar (CXB), Bangladesh. These pilot efforts strove to include the use of more participatory methodologies in the process of developing the new MHM-supportive WASH approaches.Methods: A qualitative assessment was conducted in the Rohingya refugee camps in CXB in September of 2019 to capture new approaches and practical insights on innovating for menstrual disposal, waste management and laundering. This included Key Informant Interviews with 19 humanitarian response staff from the WASH and Protection sectors of a range of non-governmental organizations and UN agencies; Focus Group Discussions with 47 Rohingya adolescent girls and women; and direct observations of 8 WASH facilities (toilets, bathing, and laundering spaces).Results: Key findings included one, the identification of new female-driven consultation methods aimed at improving female beneficiary involvement and buy-in during the design and construction phases; two, the design of new multi-purpose WASH facilities to increase female beneficiary usage; three, new menstrual waste disposal innovations being piloted in communal and institutional settings, with female users indicating at least initial acceptability; and four, novel strategies for engaging male beneficiaries in the design of female WASH facilities, including promoting dialogue to generate buy-in regarding the importance of these facilities and debate about their placement.Conclusions: Although the identified innovative participatory methodologies and design approaches are promising, the long term viability of the facilities, including plans to expand them, may be dependent on the continued engagement of girls and women, and the availability of resources.
Intratumoral Hemorrhage in Jugular Foramen Schwannoma after Stereotactic Radiosurgery: A Case Report
Authors: Kawashima Mariko , Hasegawa Hirotaka , Shin Masahiro , Shinya Yuki , Saito Nobuhito 
Published: July 2020

Abstract
Background: Clinically significant intratumoral hemorrhage is an extremely rare complication of stereotactic radiosurgery (SRS) for benign tumors.Case Presentation:Here, we present the case of a 64-year-old man who underwent SRS for a relatively large dumbbell-shaped left jugular foramen schwannoma and thereafter developed intratumoral hemorrhage. On post-SRS day 3, he developed lower cranial nerve palsies with radiographically evident tumor expansion. His neurological conditions had gradually improved thereafter; however, he suddenly developed headache, dizziness, and mild hearing deterioration at seven months due to intratumoral hemorrhage. We managed the patient conservatively, and eventually his symptoms improved except for slight ataxia and hearing deterioration. Follow-up images at three years from SRS demonstrated significant tumor shrinkage. This is the first report describing intratumoral hemorrhage after SRS for jugular foramen schwannoma.Conclusions:Transient expansion of the tumor and subsequent venous stasis around the tumor may have played a role in the hemorrhage. Intratumoral hemorrhage should be considered as a rare but potential complication of SRS for jugular foramen schwannomas.