bluuebunny/crossref_metadata_2025_split huggingface dataset:
Errors in estimated gestational ages reduce the likelihood of health facility deliveries: results from an observational cohort study in Zanzibar
Authors: Fulcher Isabel , Hedt Kaya , Marealle Stella , Tibaijuka Jalia , Abdalla Omar , Hofmann Rachel , Layer Erica , Mitchell Marc , Hedt-Gauthier Bethany 
Published: January 2020

Abstract
Background
Most maternal health programs in low- and middle- income countries estimate gestational age to provide appropriate antenatal care at the correct times throughout the pregnancy. Although various gestational dating methods have been validated in research studies, the performance of these methods has not been evaluated on a larger scale, such as within health systems. The objective of this research was to investigate the magnitude and impact of errors in estimated delivery dates on health facility delivery among women enrolled in a maternal health program in Zanzibar.

Methods
This study included 4225 women who were enrolled in the Safer Deliveries program and delivered before May 31, 2017. The exposure of interest was error in estimated delivery date categorized as: severe overestimate, when estimated delivery date (EDD) was 36 days or more after the actual delivery date (ADD); moderate overestimate, when EDD was 15 to 35 days after ADD; accurate, when EDD was 6 days before to 14 days after ADD; and underestimate, when EDD was 7 days or more before ADD. We used Chi-squared tests to identify factors associated with errors in estimated delivery dates. We performed logistic regression to assess the impact of errors in estimated delivery dates on health facility delivery adjusting for age, district of residence, HIV status, and occurrence of past home delivery.

Results
In our data, 28% of the estimated delivery dates were a severe overestimate, 23% moderate overestimate, 41% accurate, and 8% underestimate. Compared to women with an accurate delivery date, women with a moderate or severe overestimate were significantly less likely to deliver in a health facility (OR = 0.71, 95% CI: [0.59, 0.86]; OR = 0.74, 95% CI: [0.61, 0.91]). When adjusting for multiple confounders, women with moderate overestimates were significantly less likely to deliver in a health facility (AOR = 0.76, 95% CI: [0.61, 0.93]); the result moved slightly towards null for women with severe overestimates (AOR = 0.84, 95% CI: [0.69, 1.03]).

Conclusions
The overestimation of women’s EDDs reduces the likelihood of health facility delivery. To address this, maternal health programs should improve estimation of EDD or attempt to curb the effect of these errors within their programs.
Using the WHO-AIMS to inform development of mental health systems: the case study of Makueni County, Kenya
Authors: Mutiso Victoria N. , Musyimi Christine W. , Gitonga Isaiah , Tele Albert , Pervez Romaisa , Rebello Tahilia J. , Pike Kathleen M. , Ndetei David M. 
Published: January 2020

Abstract
Background
In order to develop a context appropriate in mental health system, there is a need to document relevant existing resources and practices with a view of identifying existing gaps, challenges and opportunities at baseline for purposes of future monitoring and evaluation of emerging systems. The World Health Organization Assessments Instrument for Mental Health Systems (WHO-AIMS) was developed as a suitable tool for this purpose. Our overall objective of this study, around which research questions and specific aims were formulated, was to establish a baseline on mental health system as at the time of the study, at Makueni County in Kenya, using the WHO-AIMS.

Methods
To achieve our overall objective, answer our research questions and achieve specific aims, we conducted a mixed methods approach in which we did an audit of DHIS records and county official records, and conducted qualitative interviews with the various officers to establish the fidelity of the data according to their views. The records data was processed via the prescribed WHO-Aims 2.2 excel spreadsheet while the qualitative data was analyzed thematically. This was guided by the six domains stipulated in the WHO AIMS.

Results
We found that at the time point of the study, there were no operational governance, policy or administrative structures specific to mental health, despite recognition by the County Government of the importance of mental health. The identified interviewees and policy makers were cooperative and participatory in identifying the gaps, barriers and potential solutions to those barriers. The main barriers and gaps were human and financial resources and low prioritization of mental health in comparison to physical conditions. The solutions lay in bridging of the gaps and addressing the barriers.

Conclusion
There is a need to address the identified gaps and barriers and follow up on solutions suggested at the time of the study, if a functional mental health system is to be achieved at Makueni County.
Fabrication and characterization of PLGA nanoparticles encapsulating large CRISPR–Cas9 plasmid
Authors: Jo Ami , Ringel-Scaia Veronica M. , McDaniel Dylan K. , Thomas Cassidy A. , Zhang Rui , Riffle Judy S. , Allen Irving C. , Davis Richey M. 
Published: January 2020

Abstract
Background
The clustered regularly interspaced short palindromic repeats (CRISPR) and Cas9 protein system is a revolutionary tool for gene therapy. Despite promising reports of the utility of CRISPR–Cas9 for in vivo gene editing, a principal problem in implementing this new process is delivery of high molecular weight DNA into cells.

Results
Using poly(lactic-co-glycolic acid) (PLGA), a nanoparticle carrier was designed to deliver a model CRISPR–Cas9 plasmid into primary bone marrow derived macrophages. The engineered PLGA-based carriers were approximately 160 nm and fluorescently labeled by encapsulation of the fluorophore 6,13-bis(triisopropylsilylethynyl) pentacene (TIPS pentacene). An amine-end capped PLGA encapsulated 1.6 wt% DNA, with an encapsulation efficiency of 80%. Release studies revealed that most of the DNA was released within the first 24 h and corresponded to ~ 2–3 plasmid copies released per nanoparticle. In vitro experiments conducted with murine bone marrow derived macrophages demonstrated that after 24 h of treatment with the PLGA-encapsulated CRISPR plasmids, the majority of cells were positive for TIPS pentacene and the protein Cas9 was detectable within the cells.

Conclusions
In this work, plasmids for the CRISPR–Cas9 system were encapsulated in nanoparticles comprised of PLGA and were shown to induce expression of bacterial Cas9 in murine bone marrow derived macrophages in vitro. These results suggest that this nanoparticle-based plasmid delivery method can be effective for future in vivo applications of the CRISPR–Cas9 system.
The effect of a single spinal manipulation on cardiovascular autonomic activity and the relationship to pressure pain threshold: a randomized, cross-over, sham-controlled trial
Authors: Picchiottino Mathieu , Honoré Margaux , Leboeuf-Yde Charlotte , Gagey Olivier , Cottin François , Hallman David M. 
Published: January 2020

AbstractBackgroundThe autonomic nervous system interacts with the pain system. Knowledge on the effects of high velocity low amplitude spinal manipulations (SM) on autonomic activity and experimentally induced pain is limited. In particular, the effects of SM on autonomic activity and pain beyond the immediate post intervention period as well as the relationship between these two outcomes are understudied. Thus, new research is needed to provide further insight on this issue.ObjectivesThe aim was to assess the effect of a single SM (i.e. SM vs. sham) on cardiovascular autonomic activity. Also, we assessed the relationship between cardiovascular autonomic activity and level of pain threshold after the interventions.MethodWe conducted a randomized, cross-over, sham-controlled trial on healthy first-year chiropractic students comprising two experimental sessions separated by 48 h. During each session, subjects received, in a random order, either a thoracic SM or a sham manipulation. Cardiovascular autonomic activity was assessed using heart rate and systolic blood pressure variabilities. Pain sensitivity was assessed using pressure pain threshold. Measurements were performed at baseline and repeated three times (every 12 min) during the post intervention period. Participants and outcome assessors were blinded. The effect of the SM was tested with linear mixed models. The relationship between autonomic outcomes and pressure pain threshold was tested with bivariate correlations.ResultsFifty-one participants were included, forty-one were finally analyzed. We found no statistically significant difference between SM and sham in cardiovascular autonomic activity post intervention. Similarly, we found no post-intervention relationship between cardiovascular autonomic activity and pressure pain threshold.ConclusionOur results suggest that a single SM of the thoracic spine has no specific effect on cardiovascular autonomic activity. Also, we found no relationship between cardiovascular autonomic activity and pressure pain threshold after the SM. Further experimental research should consider the use of several markers of autonomic activity and a more comprehensive pain assessment.Trial registrationN°NCT03273868. Registered September 6, 2017.
On the existence of solutions for a pointwise defined multi-singular integro-differential equation with integral boundary condition
Authors: Talaee Mandana , Shabibi Mehdi , Gilani Alireza , Rezapour Shahram 
Published: January 2020

AbstractIt is important that we increase our ability for studying of complicate fractional integro-differential equation. In this paper, we investigates the existence of solutions for a pointwise defined multi-singular fractional differential equation under some integral boundary conditions. We provide an example to illustrate our main result.
Acute intermittent porphyria (AIP) in a patient with celiac disease
Authors: Nunnemann Sebastian , Uibel Christoph , Budig Petra , Mäurer Mathias 
Published: January 2020

AbstractWe present the case of an 18 year old Caucasian with known celiac disease, who suffered a severe first attack of acute intermittent porphyria (AIP) with neuropsychiatric symptoms, severe tetraparesis and respiratory insufficiency. Treatment with heme arginate and high-dose intravenous glucose and rigorous rehabilitation resulted in a slow but almost complete recovery of her motor symptoms. To our knowledge this is the first case of acute intermittent porphyria triggered by malnutrition in the context of celiac disease. It is remarkable that the patient showed a favourable outcome despite the severity of her initial symptoms. This case shows the importance of early and systematic symptomatic treatment in patients with severe neurologic manifestation of AIP.
On inertial navigation and attitude initialization in polar areas
Authors: Wu Yuanxin , He Chao , Liu Gang 
Published: January 2020

AbstractInertial navigation and attitude initialization in polar areas become a hot topic in recent years in the navigation community, as the widely-used navigation mechanization of the local level frame encounters the inherent singularity when the latitude approaches 90°. Great endeavors have been devoted to devising novel navigation mechanizations such as the grid or transversal frames. This paper highlights the fact that the common Earth-frame mechanization is sufficiently good to handle the singularity problem in polar areas. Simulation results are reported to demonstrate the singularity problem and the effectiveness of the Earth-frame mechanization.
Research on BeiDou anti-spoofing technology based on comprehensive radio determination satellite service
Authors: Wang Fei , Hu Caibo , Wu Shuang , Tao Yixue , Xu Yunxiang 
Published: January 2020

AbstractThe BeiDou system (BDS) plays a significant role in people’s lives, but its security is easily affected by spoofing attacks. The radio determination satellite service (RDSS) is a special service of BDS that provides two-way communication, positioning, and timing services independently of the traditional radio navigation satellite service (RNSS). It can additionally be combined with RNSS to provide a comprehensive RDSS (CRDSS) service. In RDSS, after receiving a signal from the master station, the user needs to send a response signal back to the master station through a satellite. Therefore, the RDSS signal is difficult to spoof. In this study, based on the security feature of RDSS signals, an anti-spoofing method based on CRDSS is proposed to detect and mitigate spoofing attacks, verifying the advantages of the BeiDou system over other satellite navigation systems.
ПРИДАНИЕ ОГНЕЗАЩИТНЫХ СВОЙСТВ ЦЕЛЛЮЛОЗНЫМ ТЕКСТИЛЬНЫМ МАТЕРИАЛАМ С ПРИМЕНЕНИЕМ ЗОЛЬ - ГЕЛЬ ТЕХНОЛОГИИ
Authors: Tausarova Bijamal Raimovna , Stasenko Anastasiya Yur'yevna 
Published: January 2020

The article presents studies on the use of a new composition based on sodium silicate, urea and sodium hydrogen phosphate to impart fire-retardant properties to cellulosic textile materials. The influence of the concentration of the starting components, temperature, and heat treatment time on the flame retardant properties was studied. The change in the fire retardant properties of cotton fabric is given for three heat treatment modes: at 80, 90 and 100 °C. Compared to the initial fabric, the samples treated with a flame retardant have indicators of flame retardant properties. Untreated fabric with a size of 220×170 mm when tested for flammability at an ignition time of 15 s completely burns out in 60 s. In samples treated with a flame retardant, at an ignition time of 15 s, the smoldering time is practically reduced to zero. With an increase in the concentration of the flame retardant, and the temperature of the heat treatment, the loss of material strength, breaking load, and the appearance of the fabric change slightly. Using electron scanning microscopy and energy dispersive microanalysis, it was shown that pure cotton fabric contains 68.77% carbon and 31.22% oxygen; after modification, particles of sodium – 0.02%, phosphorus – 0.04% and potassium – 0.05% are formed on the surface of the treated fabric. distributed fairly unevenly. It has been shown that in cellulosic materials modified with compositions based on sodium silicate and urea, sodium hydrogen phosphate, flame retardant properties increase. The proposed composition provides the achievement of higher fire resistance. Processing can be carried out on standard equipment of finishing enterprises without the stage of high-temperature fixation of the drug.
ACCUMULATION AND DISTRIBUTION OF BIOLOGICALLY ACTIVE SUBSTANCES IN RAW MATERIALS OF SOME TAXA OF THE GENUS PAEONIA L.
Authors: Reut Antonina Anatol'yevna , Denisova Svetlana Galimullovna , Pupykina Kira Aleksandrovna 
Published: January 2020

The main purpose of the article was to study the content of the biochemical composition of different raw materials (flowers, leaves, stems, roots) of some representatives of the genus Paeonia L. (species ‒ P. peregrina Mill., P. officinalis L., P. lactiflora Pall., P. delavayi Franch., varieties ‒ Mechta S.P. Koroleva, Olga Kravchenko, Polyarnik 8, Sabantuy), introduced and grown on the basis of the South-Ural Botanical Garden-Institute of Ufa Federal Research Centre of Russian Academy of Sciences for further use as a new source of medicinal plant raw materials. The presence of amino acids was determined by the amino acid analyzer AAA-339 (HSSR), elemental composition ‒ by atomic absorption spectrometry. As a result of commodity analysis found that the leaves of paeony in maximum quantities accumulate ascorbic acid and starch; in the roots – sugar; in the stems – fiber; in flowers – carotenoids and protein. The study of the elemental composition of paeony showed that the P. peregrina quantitative content of calcium, phosphorus, iron, copper, manganese is superior to other types of peony; among the varieties, the maximum values of sodium, calcium, copper and iodine were noted in Olga Kravchenko. The presence of 14 amino acids, 9 of which are essential, was revealed. The maximum accumulation of amino acids is observed in the leaves of most species and in the stems of varieties of paeony. The amount of essential amino acids is 2.51–4.88 mg/%, the sum of all amino acids is 5.96–9.46 mg/%, which reflects the biological value of the objects of study.
FATTY ACIDS COMPOSITION AND PHYSICO-CHEMICAL CONSTANTS OF PUNICA GRANATUM L. SEED OIL
Authors: Zeynalova Aydan Mirza gyzy , Novruzov El'dar Novruz ogly 
Published: January 2020

One of the important sources of essential fatty acids may be products of plant origin, in particular, oils extracted from seeds of wild and cultivated plants. One of these resources is wild-growing Punica granatum. The fatty acid composition of the lipid fractions of the seeds of wild-type pomegranate growing on the territory of Galalti, Siyazan region of the Azerbaijan Republic was assessed by gas chromatography after conversion to the methyl esters of the corresponding fatty acids. The highest oil yield – 12.92% was obtained by the extraction of the seeds at 60 °C for 8 h by Soxhlet extractor. Chromatographic analysis of the fatty oil of pomegranate seeds made it possible to establish the presence of 9 higher fatty acids. The main component of P. granatum seed oil was punicic acid (79.64%). Palmitic and stearic acids were found in small quantities. Content of these fatty acids were 3.29% and 2.43%, respectively. The least amount is accounted for by the share of myristic (0.03%) and heptadecanoic acids (0.03%).The analyses of physico-chemical constants and organoleptic properties of seed oil of P. granatum L. shows that the saponification numbers of wild-type pomegranate was 192.91 that indicates higher solubility of soap in water that can be made from it. The percentage of free fatty acids in our sample was 0.20% and the peroxide value – 3.03. The obtained results allow to consider the seed oil of this plant as good dietary fatty acid source. Thus, this study can provide valuable information for medicine and food industry for the development of drugs and food additives based on Azerbaijan wild-type pomegranate seed oil.
THE EFFECT OF PURIFIED AMOUNT OF TRITERPENE GLYCOSIDES AND THEIR ENRICHED EXTRACT FROM LEAVES OF SILPHIUM PERFOLIATUM L. ON THE GROWTH AND ACTIVITY OF NITRATE REDUCTASE OF WIN-TER WHEAT PLANTS
Authors: Davidyants Eleonora Sergeyevna 
Published: January 2020

The effect of seed treatment with solutions of a purified amount of triterpene glycosides (PATG) containing, as major components, oleanolic acid glycosides – sylphiosides B, C, E, G, and extract (E) enriched with sylphiosides, from Silphium perfoliatum L. (Asteraceae) leaves on growth parameters and nitrate reductase activity (NR, EC 1.6.6.1) of 7-day winter wheat plants (Tritium aestivum L.) was studied. It was shown that, seed treatment with PATG solutions in concentrations of 0.0005 and 0.001% and E in concentrations of 0.2 and 0.4% caused an increase in the length of roots, shoots, wet and dry weight of seedlings compared to the control. The stimulating effect of these concentrations of PATG and E on the total nitrate reductase activity of the roots and leaves of seedlings has been established, and an increase in the stimulating effect of preparations on the activity NR оf against the background of substrate activation of the enzyme potassium nitrate (KNO3) was observed. The greatest increase in the total NR activity of roots and leaves of winter wheat plants was observed when PATG acted at a concentration of 0.001% and E – at a concentration of 0.4%, which amounted respectively 122 and 116%, when adding 1 ml of 50 mM KNO3 solution into the growing medium of plants – 141 and 137% relative to the control. The stimulating effect of exogenous triterpene glycosides on NR activity has been established for the first time. The obtained data allow to theoretically substantiate the possibility of practical use of triterpene glycosides and preparations based on them for the regulation of growth and nitrogen metabolism of plants.
Numéro 155 - janvier 2020
Authors: Attanasi Gautier , Bodart Vincent , Courtoy François , Fontenay Sébastien , Lachapelle Nathan , Ounnas Alexandre , Sauvenier Mathieu 
Published: January 2020

Malgré un environnement économique international affaibli, l’économie belge a progressé de 1,3 % en 2019. Cette expansion demeure néanmoins modeste et plus faible qu’en 2018. La croissance de l’économie belge resterait timide en 2020. L’environnement économique international demeure en effet perturbé par les tensions commerciales et par les conséquences économiques du Brexit. Au niveau belge, le sentiment de confiance des ménages et des entreprises reste faible. La progression du pouvoir d’achat serait par ailleurs nettement ralentie en 2020. La contribution de la demande intérieure à la croissance serait donc limitée en 2020.
En résumé, nos prévisions macroéconomiques pour 2020 sont les suivantes :
• L’économie belge devrait croître de 1,3 % en 2020.• L’emploi augmenterait, en termes nets, de 44.300 unités en 2020.• Le nombre de demandeurs d’emploi diminuerait de 14.000 unités en 2020.• L’inflation générale des prix à la consommation s’élèverait à 1,4 % en 2020.• Le déficit budgétaire des administrations publiques s’élargirait à 2,3 % du PIB en 2020.
Prediction of pipeline restart using different rheological models of gelled crude oil
Authors: Lei Chen , Junjie Gao , Gang Liu , Keping Zhai , Yuyu Zhang , Jingyang Gao 
Published: January 2020

Abstract
Shutdown of a waxy crude oil pipeline is unavoidable due to maintenance or emergency. It is critical to select the rheological models of gelled crude oil when investigating the pipeline restart process. Three crude oil rheological models are summarized based on previous researches in this paper, which are the viscoelastic model of a viscous type (Model 1), viscoelastic model of an elastic type (Model 2), and pure viscous thixotropic model without yield stress (Model 3). The same rheological data was fitted by the three models respectively. The critical state that pipeline can restart successfully is dominated by the slow creep of the gelled crude oil that can be regarded as an incompressible pipe flow, and this is verified by the pipe restart experiments under constant pressure conditions in this paper. To discuss the effects of the rheological models on calculation of pipeline restart separately, a simplified one-dimensional mathematical model with the pump boundary condition is established. The different calculated flow rate indicates that rheological models affect the judgement of the pipeline restart even though they are fitted from the same rheological data.
Propuesta de lineamientos para el diseño de un centro de investigación en la UNAD
Authors: Castellanos Riveros Alberto , Pineda Ballesteros Eliecer , Tellez Acuña Freddy Reynaldo 
Published: January 2020

En este artículo se presentan los resultados de un ejercicio académico orientado a definir una serie de lineamientos que posibiliten la creación de un centro de investigación, con énfasis en las líneas de investigación de la Escuela de Ciencias Agrarias, Pecuarias y del Medio Ambiente (ECAPMA), en la zona Centro Oriente de la UNAD (Santander, Norte de Santander y Arauca). Inicialmente se presentan los referentes teóricos en el área de estructuras organizacionales, físicas y de laboratorios, propias de un centro de investigación. Se describen posteriormente los lineamientos requeridos para el diseño y puesta en marcha de un centro de gestión, ubicado en el contexto de la región. Seguidamente se exponen los resultados del rastreo bibliográfico realizado sobre las estructuras físicas, organizacionales y funcionales de los centros de investigación, elaborando a partir de ella, unos lineamientos que posibiliten el diseño de una estructura acorde a las políticas de investigación del Estado Colombiano, la UNAD y los intereses del sector productivo del agro colombiano. Finalmente se presenta una serie de recomendaciones que conducen a la implementación de un centro de investigación, conocido en la UNAD como nodo de gestión (Leal, 2015).