bluuebunny/crossref_metadata_2025_split huggingface dataset:
"You Can Collaborate and Go Together to Do Family Planning”: A Qualitative Endline Evaluation Study of Male Engagement in Promoting Reproductive, Maternal, Newborn and Child Health Services in Rural Kenya.
Authors: Lusambili Adelaide M , Wisofschi Stefania , Shumba Constance , Muriuki Peter , Obure Jerim , Mantel Michaela , Mossman Lindsay , Pell Rachel , Nyaga Lucy , Ngugi Anthony , Orwa James , Luchters Stanley , Mulama Kennedy , Wade Terrance , Temmerman Marleen 
Published: December 2020

Abstract
BackgroundGlobally, male involvement in reproductive, maternal, newborn and child health (RMNCH) is associated with increased benefits for women, their children, and their communities. Between 2016 and 2020, the Aga Khan University has been implementing the Access to Quality of Care through Extending and Strengthening Health Systems (AQCESS), project funded by the Government of Canada and Aga Khan Foundation Canada (AKFC). A key component of the project was to encourage greater male engagement in RMNCH in rural Kisii and Kilifi, two predominantly patriarchal communities in Kenya, through a wide range of interventions. Towards the end of the project, we conducted a qualitative evaluation to explore how male engagement strategies influenced access to and utilization of RMNCH services.AIM This paper presents the endline evaluative study findings on how male engagement influenced reproductive, maternal, newborn and child health in rural Kisii and Kilifi.METHODSThe study used complementing qualitative methods in the AQCESS intervention areas. We conducted 10 focus group discussions with the community members across four groups including adult women, adult men, adolescent girls, and adolescent boys. We also conducted 11 key informant interviews with facility health managers,and sub county and county officials who were aware of the AQCESS project.FINDINGSMale engagement activities in Kisii and Kilifi counties were linked to improved knowledge and uptake of family planning, spousal/partner accompaniment to facility care and defeminization of social and gender roles.CONCLUSIONThis study supports the importance of male involvement in RMNCH in facilitating decisions on women and children’s health as well as in improving spousal support for use of family planning methods.
Prognosis of Liver Transplantation: Does Postoperative Ileus Matter ?
Authors: Bai Ruiping , An Rui , Han Kunyu , Shen Xin , Shaohua Zheng 
Published: December 2020

Abstract
Background: Nowadays, liver transplantation has become a main therapy for end-stage liver disease. However, studies show that there are high mortality and severe complications after liver transplantation. Although gastrointestinal dysfunction is a common and major complication among complications, there was rarely relative research. The study aims to elucidate the factors about ileus after liver transplantation and patients’ survival rate. Methods: We collected data (n=318, 2016–2019) from the First Affiliated Hospital of Xi’an Jiaotong University. After excluding cases, a total of 293 patients were included for this study. The subjects were divided into a non-ileus group and an ileus group. We reviewed 38 variables (including preoperative, operative and postoperative relative factors). In addition, other complications after liver transplantation and survival data were compared among groups. Results: Of the 293 patients, 23.2% (n=68) experienced postoperative ileus. Ileus patients were not different with non-ileus patients in preoperative, operative and postoperative factors. HBV-positive patients with ileus had a lower MELD score (P=0.025), and lower postoperative total bilirubin was correlated with ileus (P=0.049). Besides, Child-Pugh score of HCC patients with ileus was low (P=0.029). The complications after liver transplantation and survival rate were all not different among groups. Conclusions: According to our research, compared with non-ileus patients, we didn’t obtain the risk factors for patients with ileus. Ileus-patients didn’t increase complications after liver transplantation and didn’t decrease post-LT survival rates. But the preoperative MELD score and postoperative total bilirubin of HBV-positive patients with ileus were lower, and Child-Pugh score of HCC patients with ileus was also lower.
Nomogram to Predict Cause-specific Mortality of Patients with Rectal Adenocarcinoma Undergoing Surgery: A Competing Risk Analysis.
Authors: Zhang Xu , Xu Fengshuo , Bin Yadi , Liu Tianjie , Li Zhichao , Guo Dan , Li Yarui , Huang Qiao , Lyu Jun , He Shuixiang 
Published: December 2020

Abstract
Background: Rectal adenocarcinoma is one of major public health problems, severely threatening people’s health and life. Cox proportional hazard models have been applied in previous studies widely to analyze survival data. However, such models ignore competing risks and treat them as censored, resulting in excessive statistical errors. Therefore, a competing-risk model was applied with the aim of decreasing risk of bias and thereby obtaining more-accurate results and establishing a competing-risk nomogram for better guiding clinical practice.Methods: A total of 22,879 rectal adenocarcinoma cases who underwent primary-site surgical resection were collected from the SEER (Surveillance, Epidemiology, and End Results) database. Death due to rectal adenocarcinoma (DRA) and death due to other causes (DOC) were two competing endpoint events in the competing-risk regression analysis. The cumulative incidence function (CIF) for DRA and DOC at each time point was calculated. Gray’s test was applied in the univariate analysis and Gray’s proportional subdistribution hazard model was adopted in the multivariate analysis to recognize significant differences among groups and obtain significant factors that could affect patients’ prognosis. Next, A competing-risk nomogram was established predicting the cause-specific outcome of rectal adenocarcinoma cases. Finally, we plotted calibration curve and calculated concordance indexes (c-index) to evaluate the model performance.Results: 22,879 patients were included finally. The results showed that age, race, marital status, chemotherapy, AJCC stage, tumor size, and number of metastasis lymph nodes were significant prognostic factors for postoperative rectal adenocarcinoma patients. We further successfully constructed a competing-risk nomogram to predict the 1-year, 3-year, and 5-year cause-specific mortality of rectal adenocarcinoma patients. The calibration curve and C-index indicated that the competing-risk nomogram model had satisfactory prognostic ability.Conclusion: Competing-risk analysis could help us obtain more-accurate results for rectal adenocarcinoma patients who had undergone surgery, which could definitely help clinicians obtain accurate prediction of the prognosis of patients and make better clinical decisions.
Treatment of Canine Cognitive Dysfunction With Novel Butyrylcholinesterase Inhibitor
Authors: Pipan Maja Zakošek , Mihevc Sonja Prpar , Štrbenc Malan , Košak Urban , Ilić Ilija German , Trontelj Jurij , Žakelj Simon , Gobec Stanislav , Pavlin Darja , Majdič Gregor 
Published: December 2020

Abstract
Background: Canine cognitive dysfunction (CCD) is common in aged dogs and has many similarities with Alzheimer’s disease. Unfortunately, like Alzheimer’s disease, CCD cannot be cured. Methods: In the present study, we treated dogs with CCD with our newly developed and characterized butyrylcholinesterase inhibitor (BChEi). Seventeen dogs were randomized into two groups (treated with BChEi and untreated) and followed for 6 months at regular check-ups. The dogs’ cognitive status was determined by a CADES questionnaire and two cognitive tests. Results: In dogs with moderate cognitive impairment, treatment caused significant improvement in the clinical rating of cognitive abilities and the performance-based tests of cognitive functioning when compared to the untreated group (p < 0.001). Dogs treated with BChEi showed markedly improved cognitive function with enhanced quality of life. No side effects were observed in the treated dogs with moderate cognitive impairment. Conclusions: Novel BChE inhibitor is a promising candidate for treating CCD, and might be an interesting canidate drug for the treatment of Alzheimer disease in humans.
Inhibition of DEC2&nbsp;is Necessary for Exiting Cell Dormancy in Salivary Adenoid Cystic Carcinoma&nbsp;
Authors: Yang Xiao , Wu Jia-shun , Li Mao , Zhang Wei-long , Gao Xiao-lei , Wang Hao-fan , Yu Xiang-hua , Pang Xin , Zhang Mei , Liang Xin-hua , Tang Ya-ling 
Published: December 2020

Abstract
Background: Patients were prone to have poor prognosis once dormant tumor cells being reactivated. However, the molecular mechanism of tumor cell dormancy remains poorly understood. This study aimed to investigate the function of DEC2 in the dormancy of salivary adenoid cystic carcinoma (SACC) in vitro and vivo. Methods: The function of DEC2 in tumor dormancy of SACC was investigated in nude mice by establishing primary and lung metastasis model. Meanwhile, the interaction between hypoxia and SACC dormancy and the role of DEC2 were demonstrated through CoCl2 induced hypoxia–mimicking microenvironments. Furthermore, the expression of DEC2 was detected by immunohistochemical staining in primary SACC samples with and without recurrence. Results: In the primary SACC, DEC2 overexpression inhibited cell proliferation, increased cell population arrested in G0/G1 phase, and participated in dormancy regulation, which limited tumor growth. Intriguingly, in the model of lung metastasis, the level of DEC2 was reduced significantly and resulted in dormancy exit and growth resumption of SACC cells. Then, we found that DEC2 may associate with hyoxia in contributing to tumor dormancy, which might provide a possible cue to explain the different roles of DEC2 in primary and metastasis lesions. And overexpression of DEC2 induced dormancy and promoted migration and invasion through activating EMT program. Finally, DEC2 positive expression was shown to be significantly correlated with recurrence and dormancy of SACC patients. ﻿Conclusions: These findings provide a novel insight into the role of DEC2 gene in tumor dormancy and metastasis.
A Multi-objective Trajectory Planning Method Based on the Improved Elitist Non-dominated Sorting Genetic Algorithm
Authors: Wang Zesheng , Li Yanbiao , Shuai Kun , Zhu Wentao , Chen Bo , Chen Ke 
Published: December 2020

Abstract
A multi-objective trajectory planning approach based on an improved elitist non-dominated sorting genetic algorithm (INSGA-II) is proposed. Trajectory function is planned with a new composite polynomial that by combining of quintic polynomials with cubic Bezier curves. Then, an INSGA-II, by introducing three genetic operators: ranking group selection (RGS), direction-based crossover (DBX) and adaptive precision-contrallable mutation (APCM), is developed to optimize travelling time and torque fluctuation. Inverted generational distance, hypervolume and optimizer overhead are selected to evaluate the convergence, diversity and computational effort of algorithms. The optimal solution is determined via fuzzy comprehensive evaluation to obtain the optimal trajectory. Taking a serial-parallel hybrid manipulator as instance, the velocity and acceleration profiles obtained using this composite polynomial are compared with those obtained using a quintic B-spline method. The effectiveness and practicability of the proposed method are verified by simulation results.
Disease Activity Index Is Associated With Subclinical Atherosclerosis in Childhood-onset Systemic Lupus Erythematosus
Authors: Medeiros Priscila Beatriz de Souza , Salomão Roberta G , Teixeira Sara R , Rassi Diane Meyre , Rodrigues Luciana , Aragon Davi Casale , Fassini Priscila Giacomo , Ued Fábio Veiga , Tostes Rita C , Monteiro Jacqueline P , Ferriani Virgínia Paes Leme , De Carvalho Luciana Martins 
Published: December 2020

Abstract
Background: Systemic lupus erythematosus (SLE) is an independent risk factor for cardiovascular events. The present study determined the prevalence of subclinical atherosclerosis in childhood-onset SLE using the carotid intima-media thickness (CIMT) measurement and investigated associations between traditional and nontraditional risk factors for atherosclerosis, such as medications, SLE Disease Activity Index - SLEDAI-2K and SLICC-ACR damage index and CIMT. Methods: Cross-sectional prospective study between 2017-2018. CIMT was assessed by ultrasonography. Data were collected by chart review, nutritional evaluation and laboratory tests and analyzed by Fisher, Wilcoxon-Mann-Whitney tests, multiple linear and log binomial regression. Results: Twenty-eight patients (mean age 13.9 years, SD 3) were enrolled. The prevalence of subclinical atherosclerosis was 32% (95% CI 14.8, 49.4). The mean CIMT was 0.43 ± 0.035 mm. The most common traditional risk factors observed were dyslipidemia (89.3%), uncontrolled hypertension (66.6%), overweight (32%) and poor diet (78.6%). Uncontrolled hypertension (p=0.04), proteinuria (p=0.02), estimated glomerular filtration rate < 75ml /min/1.73 m2 (p=0.02) and SLEDAI-2K > 5 (P=0.004) were associated with subclinical atherosclerosis. SLEDAI-2K > 5 maintained association with CIMT after adjusting for control variables. Conclusion: Subclinical atherosclerosis is frequently observed in cSLE, mainly in patients with moderate to severe disease activity.
Amino Acid Transporter (AAT) Gene Family In Foxtail Millet (Setaria Italica L.): Widespread Family Expansion, Functional Differentiation, Roles In Quality Formation And Response To Abiotic Stresses
Authors: Yang Yang , Chai Yongmao , Liu Jiayi , Zheng Jie , Zhao Zhangchen , Aduragbemi Amo , Cui Chunge , Lu Qiumei , Chen Liang , Hu Yin-Gang 
Published: December 2020

Abstract
Background: Amino acid transporters (AATs) plays an essential roles in growth and development of plants, including amino acids long-range transport, seed germination, quality formation, responsiveness to pathogenic bacteria and abiotic stress by modulating the transmembrane transfer of amino acids. In this study, we performed a genome-wide screening to analyze the AAT genes in foxtail millet (Setaria italica L.), especially those associated with quality formation and abiotic stresses response.Results: A total number of 94 AAT genes were identified and divided into 12 subfamilies by their sequence characteristics and phylogenetic relationship. A large number (58/94, 62%) of AAT genes in foxtail millet were expanded via gene duplication, involving 13 tandem and 12 segmental duplication events. Tandemly duplicated genes had a significant impact on their functional differentiation via sequence variation, structural variation and expression variation. Further comparison in multiple species showed that in addition to paralogous genes, the expression variations of the orthologous AAT genes also contributed to their functional differentiation. The transcriptomic comparison of two millet cultivars verified the direct contribution of the AAT genes such as SiAAP1, SiAAP8, and SiAUX2 in the formation of grain quality. In addition, the qRT-PCR analysis suggested that several AAT genes continuously responded to diverse abiotic stresses, such as SiATLb1, SiANT1. Finally, combined with the previous studies and analysis on sequence characteristics and expression patterns of AAT genes, the possible functions of the foxtail millet AAT genes were predicted.Conclusion: This study for the first time reported the evolutionary features, functional differentiation, roles in the quality formation and response to abiotic stresses of foxtail millet AAT gene family, thus providing a framework for further functional analysis of SiAAT genes, and also contributing to the applications of AAT genes in improving the quality and resistance to abiotic stresses of foxtail millet, and other cereal crops.
Identification and Verification of Genes Related to Pollen Development and Male Sterility Induced by High Temperature in Thermo-sensitive Genic Male Sterile Wheat Line YanZhan 4110S
Authors: Yang Xuetong , Ye Jiali , Niu Fuqiang , Feng Yi , Song Xiyue 
Published: December 2020

Abstract
Background: Environment-sensitive genic male sterility is of vital importance to hybrid vigor in crop production and breeding, therefore, it is meaningful to identify and study the function of the genes related to pollen development and male sterility, which still not fully understanding currently. In this study, Yanzhan 4110S, a new thermo-sensitive genic male sterility (TGMS) wheat line, and its near isogenic line Yanzhan 4110 were carried out cytological features observation, bioinformatics analysis to investgate the abortion state and identified the genes involved in pollen development which have fertility regulation function. Barely stripe mosaic virus-induced gene silencing was used to verify the genes function.Results: Cytological analysis showed pollen abortion event of Yanzhan 4110S occur at the later uninucleate stage (Lun) under higher temperature induction (day/night temperatures of 22 °C/20 °C), when the anthers were collected and assessed for transcriptomic profiling through high-throughput sequencing. We then in-depth analyzed the differentially expressed genes (DEGs) by Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, the results showed that the occurrence of Yanzhan 4110S male-sterility most likely related to metabolic pathway, including phenylpropanoid biosynthesis in the biosynthesis of other secondary metabolites, starch and sucrose metabolism in carbohydrate metabolism, carbon fixation in photosynthetic organisms as well as carbon metabolism in energy metabolism. The weighted gene co-expression network analysis in the transcriptome profiles further identified some hub genes, where the key genes involved in those pathways were intersection between the unique DEGs of Yanzhan 4110S in anther and hub genes, totally 228 genes, which were highly related to pollen development including TaMut11 and TaSF3. Moreover, further verification through barely stripe mosaic virus-induced gene silencing elucidated that the silencing of TaMut11 and TaSF3 caused pollen abortion, finally resulting in the declination of fertility. So, the genes TaMut11 and TaSF3 are related to fertility conversion of Yanzhan 4110S.Conclusion: Through comparative transcriptome bioinformatics analysis, the genes TaMut11 and TaSF3 associated with pollen development and male sterility induced by high temperature were identified in Yanzhan 4110S, and verificated by barely stripe mosaic virus-induced gene silencing. These findings provided researching the abortive mechanism in environment-sensitive genic male sterility wheat.
Associated Factors of maternal satisfaction towards delivery service among mothers who gave birth at Jimma Medical Center, Jimma Town, Southwest Ethiopia
Authors: Woldasemayat Lalisa Ayele , Badada Gadisa Bekele , Negasa Melkamu Gelan 
Published: December 2020

Abstract
Background and aim: Assurance of health care for all segments of the population with special attention given to women and children was one of the top priorities in Ethiopian health policy. Maternal and newborn deaths are heavily concentrated at the period of delivery and early postpartum. Thus, this study aimed to assess Associated Factors with maternal satisfaction towards delivery service among mothers who gave birth at Jimma Medical Center, Jimma Town, Southwest Ethiopia.Methods: Institutional based cross-sectional study using face to face interview was conducted in Jimma Medical Center from April 01 to May 30, 2019. A systematic sampling technique was used to select 217 study participants using a semi-structured administered questionnaire. Results: The maternal satisfaction level with the delivery services rendered at the hospital was 66.8%. Delivering mothers satisfaction was found to be associated with educational status (X2=85.4, p<0.001), parity (X2=19.2, p<0.001), distance from health facility (X2=13.5, p<0.001), Monthly income (X2=13.8, p<0.001), waiting time (X2=5.7, p<0.05), Cleanness of delivery area (X2=9.3, p<0.001).Conclusion: The magnitude of mothers satisfied with the delivery service was low compared to studies conducted in Ethiopia so far. Maternal educational status, parity, distance from the health facility, waiting time, and monthly income were associated with mothers' satisfaction with delivery service. Therefore, awareness creation should be given for the community for improving the quality of delivery service and further study should be done on the knowledge and skill of health care providers on delivery service.
Anticancer Effects of Bifidobacteria on Colon Cancer Cell Lines
Authors: Faghfoori Zeinab , Faghfoori Mohammad Hasan , Saber Amir , Izadi Azimeh , Khosroushahi Ahmad Yari 
Published: December 2020

Abstract
Background: Colorectal cancer (CRC), with a growing incidence trend worldwide, is resistant to apoptosis and have the uncontrolled proliferation. It is recently reported that probiotic microorganisms exert anticancer effects. The genus Bifidobacterium, one of the dominant bacterial populations in the gastrointestinal tract, has received increasing attention because of widespread interest in using as health-promoting microorganisms. Therefore, the present study aimed to assess the apoptotic effects of some bifidobacteria species on colon cancer cell lines.Methods: The cytotoxicity evaluations performed using MTT assay and FACS-flow cytometry tests. Also, the effects of five species of bifidobacteria secretion metabolites on the expression level of anti- or pro-apoptotic genes including BAD, Bcl-2, Caspase-3, Caspase-8, Caspase-9, and Fas-R studied by real-time polymerase chain reaction (RT-PCR) method. Results: The cell-free supernatant of all studied bifidobacteria significantly decreased the survival rates of colon cancer cells compared with control groups. Flow cytometric and RT-PCR results indicated that apoptosis is induced by bifidobacteria secretion metabolites and the mechanism for the action of bifidobacteria species in CRC prevention could be down-regulation and up-regulation of anti-apoptotic and, pro-apoptotic genes.Conclusions: In the present study, different bifidobacteria species showed anticancer activity on colorectal cancer cells through down-regulation and up-regulation of anti-apoptotic and pro-apoptotic genes. However, further studies are required to clarify the exact mechanism of apoptosis induction by bifidobacteria species.