bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic alterations underlying spinal metastases in pediatric H3K27M-mutant pineal parenchymal tumor of intermediate differentiation: case report
Authors: Fomchenko Elena I. , Erson-Omay E. Zeynep , Kundishora Adam J. , Hong Christopher S. , Daniel Ava A. , Allocco August , Duy Phan Q. , Darbinyan Armine , Marks Asher M. , DiLuna Michael L. , Kahle Kristopher T. , Huttner Anita 
Published: February 2020

Pediatric midline tumors are devastating high-grade lesions with a dismal prognosis and no curative surgical options. Here, the authors report the clinical presentation, surgical management, whole-exome sequencing (WES), and clonality analysis of a patient with a radically resected H3K27M-mutant pineal parenchymal tumor (PPT) and spine metastases consistent with PPT of intermediate differentiation (PPTID). They identified somatic mutations in H3F3A (H3K27M), FGFR1, and NF1 both in the original PPT and in the PPTID metastases. They also found 12q amplification containing CDK4/MDM2 and chromosome 17 loss of heterozygosity overlapping with NF1 that resulted in biallelic NF1 loss. They noted a hypermutated phenotype with increased C>T transitions within the PPTID metastases and 2p amplification overlapping with the MYCN locus. Clonality analysis detected three founder clones maintained during progression and metastasis. Tumor clones present within the PPTID metastases but not the pineal midline tumor harbored mutations in APC and TIMP2.While the majority of H3K27M mutations are found in pediatric midline gliomas, it is increasingly recognized that this mutation is present in a wider range of lesions with a varied morphological appearance. The present case appears to be the first description of H3K27M mutation in PPTID. Somatic mutations in H3F3A, FGFR1, and NF1 have been suggested to be driver mutations in pediatric midline gliomas. Their clonality and presence in over 80% of tumor cells in our patient’s PPTID are consistent with similarly crucial roles in early tumorigenesis, with progression mediated by copy number variations and chromosomal aberrations involving known oncogenes and tumor suppressors. The roles of APC and TIMP2 mutations in progression and metastasis remain to be investigated.
Enhancing outcomes of endoscopic vertical approach hemispherotomy: understanding the role of “temporal stem” residual connections causing recurrence of seizures
Authors: Girishan Shabari , Tripathi Manjari , Garg Ajay , Doddamani Ramesh , Bajaj Jitin , Ramanujam Bhargavi , Chandra P. Sarat 
Published: February 2020

ObjectiveThe authors sought to analyze the residual connections formed by the temporal stem as a cause for seizure recurrence following endoscopic vertical interhemispheric hemispherotomy and to review and compare lateral approach (perisylvian) with vertical approach surgical techniques to highlight the anatomical factors responsible for residual connections.METHODSThis study was a retrospective analysis of patients who underwent endoscopic hemispherotomy for drug-resistant epilepsy. Postoperative MR images were analyzed. Specific attention was given to anatomical 3D-acquired thin-section T1 images to assess the extent of disconnection, which was confirmed with a diffusion tensor imaging sequence. Cadaver brain dissection was done to analyze the anatomical factors responsible for persistent connections.RESULTSOf 39 patients who underwent surgery, 80% (31/39) were seizure free (follow-up of 23.61 ± 8.25 months) following the first surgery. Thirty patients underwent postoperative MRI studies, which revealed persistent connections in 14 patients (11 temporal stem only; 3 temporal stem + amygdala + splenium). Eight of these 14 patients had persistent seizures. In 4 of these 8 patients, investigations revealed good concordance with the affected hemisphere, and repeat endoscopic disconnection of the residual connection was performed. Two of the 8 patients were lost to follow-up, and 2 had bihemispheric seizure onset. The 4 patients who underwent repeat endoscopic disconnection had seizure-free outcomes following the second surgery, increasing the good outcome total among all patients to 90% (35/39). Cadaveric brain dissection analysis revealed the anatomical factors responsible for the persistence of residual connections.CONCLUSIONSIn endoscopic vertical approach interhemispheric hemispherotomy (and also vertical approach parasagittal hemispherotomy) the temporal stem, which lies deep and parallel to the plane of disconnection, is prone to be missed, which might lead to persistent or recurrent seizures. The recognition of this limitation can lead to improved seizure outcome. The amygdala and splenium are areas less commonly prone to be missed during surgery.
Cerebral cavernomas in adults and children express relaxin
Authors: Gewiss Caroline , Hagel Christian , Krajewski Kara 
Published: February 2020

OBJECTIVETo shed light on the role of relaxin in cerebral cavernous malformations (CCMs) in adults and children, the authors investigated endothelial cell (EC) expression of relaxin 1, 2, and 3; vascular endothelial growth factor receptor–1 and –2 (VEGFR-1 and -2); Ki-67; vascular geometry; and hemorrhage, as well as the clinical presentation of 32 patients with surgically resected lesions.METHODSParaffin-embedded sections of 32 CCMs and 5 normal nonvascular lesion control (NVLC) brain tissue samples were immunohistochemically stained with antibodies to relaxin 1, 2, and 3; angiogenesis growth factor receptors Flt-1 (VEGFR-1) and Flk-1 (VEGFR-2); and proliferation marker Ki-67. For morphometric analysis, Elastica van Gieson stain was used, and for hemorrhage demonstration, Turnbull stain was used. Data from the pediatric and adult CCMs were compared with each other and with those obtained from the NVLCs. Statistical analyses were performed with Fisher’s exact test, the chi-square test, the phi correlation coefficient, and the Student t-test. A p value < 0.05 was considered significant.RESULTSPediatric and adult cavernoma vessels did not significantly differ in diameter. Hemorrhage was observed in CCMs but not in NVLC samples (p < 0.05). There was no difference in expression of Ki-67, VEGFR-1 and -2, and relaxin 1, 2, and 3 in the ECs of pediatric and adult CCMs. The ECs of CCMs were largely negative for relaxin 3 compared to NVLCs (p < 0.05), whereas CCMs, compared to control brain tissue samples, more frequently expressed Flt-1 and relaxin 2 (p < 0.05). Ki-67 was not expressed in the NVLCs, but the difference was not statistically significant. Relaxin 1 and 2 expression and increased expression of VEGFR-1 were associated with a supra- versus infratentorial location (p < 0.05).CONCLUSIONSRelaxin 1 and 2 and VEGFR-1 play a role in supratentorial cavernomas. Relaxin 3 may play a physiological role in normal brain vasculature. Relaxin 1 and 3 are also found in normal cerebral vasculature. Relaxin 1, 2, and 3 are associated with increased VEGFR-1 expression.
Challenges in the diagnosis of severe renal trauma in child: A case report and literature review
Authors: Zhang Zejian , Zhang Yixiang , Wang Xisheng , Fang Liekui , Chen Dong , Peng Naixiong , Thakker Parth , Wang Qinjun , Zhang Yuanyuan 
Published: February 2020

INTRODUCTION: To report the management and outcome of one case of pediatric patient sustaining high-grade blunt renal trauma. We present and discuss the clinical characteristics and radiologic features of the patient. PATIENTS AND METHODS: A 10 years old child was admitted for serious blunt renal trauma formed a huge urinoma in the right renal after injury gradually in 2018. We treated the patient with synchronous percutaneous nephrostomy drainage and retrograde ureteral catheterization. A retrospective review was performed of this case, including the clinical features, imaging studies and short-term follow-up. A literature review was also performed to highlight the principals of diagnosis and treatment of severe blunt renal trauma in children. RESULTS: After drainage, the symptoms of abdominal distension gradually disappeared, and the physical examination shows that the abdomen gradually reduced to normal. The huge urinoma was cured by synchronous drainge. No complications occurred in short-term follow-up. COMMENTS: The choice of surgical treatment is based on the degree and location of renal trauma. Grade IV injuries are a heterogeneous group and management should be tailored to the patient, especially among pediatric patients. Persistent urinary extravasation and/or symptomatic urinoma is a common complication of high-grade renal trauma, which will be amenable to ureteral stent placement or percutaneous drainage. For huge urinoma, synchronous percutaneous nephrostomy drainage and retrograde ureteral catheterization can relieve symptoms quickly.
THE ROLE OF DATA IN THE VALUATION OF AN ENTERPRISE - THE COST OF EQUITY
Authors: Piątek Edyta 
Published: February 2020

The valuation of a company is a complex process and requires comprehensive knowledge. The decisions made at each stage have consequences for the next step. The first fundamental stage is to choose the standard of value that the valuer wants to determine. Only then is the appropriate valuation method selected. One of the further factors influencing the outcome of the valuation process is the cost of equity, which takes into account important parameters of the company's operation. It is the cost of equity that causes the most controversy and dilemmas. The research problem analyzed in the article is a way of calculating the cost of equity in enterprise valuation. The example of a specific valuation indicates that the cost of capital cannot be a parameter (data item) covering all risks, but only those that cannot be programmed in cash flows. In the course of research works, the valuation of enterprise B organized in the form of a general partnership as of 29.08.2014 in connection with its contribution by the shareholders to the joint-stock company A as an in-kind contribution increasing the capital was performed. Due to the fact that there is a minority shareholder in joint-stock company A, there is a dilemma of choosing the right value and valuation method and the method of calculating the cost of equity. Neither the literature on the subject in this respect, nor the parties to the transaction, indicate a clear solution, especially as regards the value of the cost of equity.
ANALYSIS OF ACCOUNTING INFORMATION SYSTEM DISTRIBUTION OF BOP RA FUND (CASE STUDY ON RA PERWANIDA KARANGREJO 02)
Authors: Mauliyah Nur Ika , Prastiwi Dwinda Agus 
Published: February 2020

The purpose of this study is to analyze the accounting information system of BOP RA funds distribution, the existence of accounting information system in the distribution of funds BOP RA as accounting information system has been run effectively as a provider of information. Analyzing the accounting information system conducted on the distribution of BOP RA funds.
This research uses descriptive qualitative method that describes thoroughly to the implementation of accounting information system applied at school RA X and compared with technical guidance as well as theories related to accounting information system, so that it can produce result desired by researcher.
The results of this study indicate that the accounting information system channeling BOP RA funds are in conformity with the reference and rules but not yet the formation of flowchart.
Does Gravity Fall Down? Evidence for Gravitational-wave Deflection along the Line of Sight to GW170817
Authors: Rubin D. , Szapudi István , Shappee B. J. , Anand Gagandeep S. 
Published: February 2020

Abstract
We present a novel test of general relativity (GR): measuring the geometric component of the time delay due to gravitational lensing. GR predicts that photons and gravitational waves follow the same geodesic paths and thus experience the same geometric time delay. We show that for typical systems, the time delays are tens of seconds, and thus can dominate over astrophysical delays in the timing of photon emission. For the case of GW170817, we use a multi-plane lensing code to evaluate the time delay due to four massive halos along the line of sight. From literature mass and distance measurements of these halos, we establish at high confidence (significantly greater than

) that the gravitational waves of GW170817 underwent gravitational deflection to arrive within 1.7 s of the photons.
X-ray microcomputed tomography applied to the taxonomic study of rare material: redescriptions of seven of Schirch’s Brazilian species of land planarians (Geoplanidae, Platyhelminthes)
Authors: Silva Marcos Santos , Carbayo Fernando 
Published: February 2020

In 2016, the type-material of ten of the 15 Brazilian land planarians (Platyhelminthes, Tricladida, Geoplanidae) described by Schirch (1929) was discovered deposited in the Museu Nacional do Rio de Janeiro (MNRJ). Schirch only described the external morphology of these species, all originally placed in the genusGeoplana. By the 1930s and 1950sGeoplana itatiayana,G. plana, andG. rezendeiunderwent taxonomic revision based on the study of non-type specimens. The remaining 12 species also underwent a taxonomic revision but only based on the literature. Current names of these species areGeoplana goettei,Pseudogeoplana arpi,Ps. blaseri,Ps. bonita,Ps. bresslaui,Ps. cardosi,Ps. doederleini,Ps. lumbricoides,Ps. obscura,Ps. riedeli,Ps. theresopolitana, andPs. wetzeli. The speciesGeoplana maximilianisensu Schirch (1929) was renamed asPs. schirchiOgren &amp; Kawakatsu, 1990.The present study reports a taxonomic revision of seven of Schirch’s species using type material, namelyObama itatiayana,Pasipha plana,Pseudogeoplana arpi,Ps. bresslaui,Ps. doederleini,Ps. schirchiandPs. wetzeli. Additional specimens of some of these species were also examined. Morphological data from histological preparations and from virtual sections were obtained through a non-destructive technique of X-ray computed microtomography (µCT). This approach resulted in the preservation of the entire body of at least one type-specimen of each species, and the holotype ofPs. bresslaui. Conspecificity ofO. itatiayanaandP. planawas confirmed, as previously reported in the literature. It is also proposed thatPs. bresslauibelongs to the genusParaba, while the other species should remain inPseudogeoplana, since type-specimens are either immature, poorly preserved or simply lost.
Communication for health in Africa: experiences and challenges
Authors: Balima Serge-Théophile 
Published: February 2020

This paper analyzes communication for health in Africa through some fields experiences. These education compaigns show that the communication approaches are little participative. They don’t take into account the socio–cultural reality of local communities and then face various methodological problems. Yet, if well conducted, health oriented communication can help to reduce the impact of recurrent health problems in Africa.
El presente artículo analiza la comunicación para la salud en África a través de algunas experiencias llevadas a cabo sobre el terreno. De estas campañas de educación se deduce que los enfoques de la comunicación son poco participativos. No integran la vivencia sociocultural de las poblaciones locales y se topan con una serie de dificultades de orden metodológico. Sin embargo la comunicación para la salud, bien enfocada, puede lograr reducir el impacto de los problemas de salud recurrentes en el continente.
The protagonism of the mass media in student’s education
Authors: Martínez-Fresneda-Osorio Humberto 
Published: February 2020

The emergence of the media as a complementary school parallel to schools, invites the educational community to rethink about the most effective way to integrate media into the school curriculum in order to encourage and help students in their education. Through this relationship among mass media reality and students themselves, schools arises as the key where offering a correct media interpretation.
La aparición de los medios de comunicación como «escuela» complementaria de formación, paralela a los centros escolares, invita a la comunidad educativa a replantearse la manera más efectiva de integrarlos en el currículum escolar con el fin de ayudar al alumno en su proceso de formación. De esta relación de los medios de comunicación con la realidad y los propios alumnos se desprende la necesidad de ofrecer, desde la escuela, claves para su correcta interpretación.
Critical reading in the Internet: assessment and aplication of its resources
Authors: Fainholc Beatriz 
Published: February 2020

The Internet as a socio-telematic media should generate and increase educational processes. Teaching and reading practice in the Internet is very necessary in order to learn to interact critically. The development of skills to explote its potencial for a deep and thoughtful comprehension with the transference to other reading situations, interaction and navigation will help for an autonomous and imaginative person.
Internet es el medio comunicacional con interacción telemática que debería generar y potenciar procesos educativos. La enseñanza y práctica de la lectura en su soporte es muy necesaria para que las personas aprendan a interactuar provechosa y críticamente. El desarrollo de capacidades para explotar su potencial hacia una comprensión profunda y reflexiva de los mensajes con la transferencia a otras situaciones de interacción, lectura y navegación coadyuvan para un sujeto autónomo y recreador.
Media, education and reality
Authors: Marín-Díaz Verónica 
Published: February 2020

Nowadays media images rule our lives. However, in early ages it is considered necessary the help of a guide to discriminate information. We want to make people reflect about the need to promote specific training on the media since childhood.La realidad de hoy presenta una imagen en la que los medios de información y comunicación dominan nuestras vidas. Este avance permite desarrollar nuevas formas de transmitir nuestros pensamientos e ideas. Sin embargo, en edades tempranas se considera necesaria la intervención de un guía que ayude a discriminar la información. En consecuencia, se debe reflexionar sobre esta necesidad de potenciar una formación específica en medios de comunicación desde la más tierna infancia.
Press as resource in the adult curriculum
Authors: Ricoy-Lorenzo María-del-Carmen 
Published: February 2020

In this paper we gather part of the research about the use of press as curricular material in basic adults´education. The work has contributed to different aspects concerning the relevance but also the obstacles that teachers face in their effort to use press in different subjects of the curriculum. The study contributes to know the circumstances of integration of press in education. It includes some improvements, and it promotes some work lines concerning this topic.
En este artículo se recoge parte de una investigación más amplia sobre el uso de la prensa como material curricular en la educación de base para adultos, aportándose diferentes aspectos en torno a la pertinencia y obstáculos que encuentra el profesorado en el trabajo que aborda con la prensa desde diferentes asignaturas del currículum. El estudio contribuye al conocimiento de las circunstancias que rodean la integración de la prensa en la educación, incorpora mejoras y potencia líneas de trabajo sobre la temática tratada.
Early Sport Specialization and Subjective Hip and Groin Dysfunction in Collegiate Ice Hockey Athletes
Authors: Sheppard Marisa , Nicknair Jim , Goetschius John 
Published: February 2020

ContextSport specialization is a popular trend among youth athletes that has been associated with an increased risk for developing lower extremity overuse injuries. Early ice hockey specialization may contribute to the high rates of noncontact and overuse hip and groin injuries in collegiate ice hockey athletes.ObjectiveTo examine the effects of high, moderate, and low levels of sport specialization on subjective hip and groin dysfunction in collegiate ice hockey athletes.DesignRetrospective cohort study.SettingData were collected during the midseason of the 2018–2019 hockey season at a local ice hockey arena.Patients or Other ParticipantsNational Collegiate Athletic Association Division III and club ice hockey players from Midwestern college programs (n = 187; 81 women, 106 men).Main Outcome Measure(s)Participants were stratified into high-, moderate-, and low-specialization groups based on ice hockey participation before grade 9 of high school. The 6 subscales of the Hip and Groin Outcome Score questionnaire were used to assess current subjective hip and groin dysfunction.ResultsThe high-specialization group had lower scores than the low-specialization group on the Symptoms (P = .001), Pain (P = .003), Activities of Daily Living (P = .001), Sport and Recreation (P = .014), and Quality of Life (P = .002) subscales. The moderate-specialization group had lower scores than the low-specialization group on the Symptoms (P = .015) and Activities of Daily Living (P = .006) subscales.ConclusionsCollegiate ice hockey athletes who were highly specialized before high school reported greater current hip and groin pain, symptoms, and dysfunction during activities of daily living and sport and recreation and lower current hip- and groin-related quality of life compared with low-specialization ice hockey athletes. Early ice hockey specialization may be detrimental to hip and groin function in collegiate ice hockey athletes.
Bootstrap methods for inference in the Parks model
Authors: Moundigbaye Mantobaye , Messemer Clarisse , Parks Richard W. , Reed W. Robert 
Published: February 2020

Abstract
This paper shows how to bootstrap hypothesis tests in the context of the Parks’s (1967) Feasible Generalized Least Squares estimator. It then demonstrates that the bootstrap outperforms FGLS(Parks)’s top competitor. The FGLS(Parks) estimator has been a workhorse for the analysis of panel data and seemingly unrelated regression equation systems because it allows the incorporation of cross-sectional correlation together with heteroskedasticity and serial correlation. Unfortunately, the associated, asymptotic standard error estimates are biased downward, often severely. To address this problem, Beck and Katz (1995) developed an approach that uses the Prais-Winsten estimator together with “panel corrected standard errors” (PCSE). While PCSE produces standard error estimates that are less biased than FGLS(Parks), it forces the user to sacrifice efficiency for accuracy in hypothesis testing. The PCSE approach has been, and continues to be, widely used. This paper develops an alternative: a nonparametric bootstrapping procedure to be used in conjunction with the FGLS(Parks) estimator. We demonstrate its effectiveness using an experimental approach that creates artificial panel datasets modelled after actual panel datasets. Our approach provides a superior alternative to existing estimation options by allowing researchers to retain the efficiency of the FGLS(Parks) estimator while producing more accurate hypothesis test results than the PCSE.