bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain
Authors: Zajaczkowska Renata , Kwiatkowski Klaudia , Pawlik Katarzyna , Piotrowska Anna , Rojewska Ewelina , Makuch Wioletta , Wordliczek Jerzy , Mika Joanna 
Published: July 2020

Abstract
Background
Treatment of neuropathic pain is still challenging. Recent studies have suggested that dorsal root ganglia (DRG), which carry sensory neural signals from the peripheral nervous system to the central nervous system, are important for pathological nociception. A proper understanding of the significance and function of DRG and their role in pharmacotherapy can help to improve the treatment of neuropathic pain. Metamizole, also known as sulpyrine or dipyrone, is a non-opioid analgesic commonly used in clinical practice, but it is not used for neuropathic pain treatment.

Methods
Chronic constriction injury (CCI) of the sciatic nerve was induced in Wistar rats. Metamizole was administered intraperitoneally (ip) preemptively at 16 and 1 h before CCI and then twice a day for 7 days. To evaluate tactile and thermal hypersensitivity, von Frey and cold plate tests were conducted, respectively.

Results
Our behavioral results provide evidence that repeated intraperitoneal administration of metamizole diminishes the development of neuropathic pain symptoms in rats. Simultaneously, our findings provide evidence that metamizole diminishes the expression of pronociceptive interleukins (IL-1beta, IL-6, and IL-18) and chemokines (CCL2, CCL4, and CCL7) in DRG measured 7 days after sciatic nerve injury. These assays indicate, for the first time, that metamizole exerts antinociceptive effects on nerve injury-induced neuropathic pain at the DRG level.

Conclusions
Finally, we indicate that metamizole-induced analgesia in neuropathy is associated with silencing of a broad spectrum of cytokines in DRG. Our results also suggest that metamizole is likely to be an effective medication for neuropathic pain.

Graphic abstract
FIRST-ORDER RECOGNIZABILITY IN FINITE AND PSEUDOFINITE GROUPS
Authors: CORNULIER YVES , WILSON JOHN S. 
Published: July 2020

AbstractIt is known that there exists a first-order sentence that holds in a finite group if and only if the group is soluble. Here it is shown that the corresponding statements with ‘solubility’ replaced by ‘nilpotence’ and ‘perfectness’, among others, are false.These facts present difficulties for the study of pseudofinite groups. However, a very weak form of Frattini’s theorem on the nilpotence of the Frattini subgroup of a finite group is proved for pseudofinite groups.
Kefir microbial composition is a deciding factor in the physiological impact of kefir in a mouse model of obesity
Authors: Bourrie Benjamin C. T. , Ju Tingting , Fouhse Janelle M. , Forgie Andrew J. , Sergi Consolato , Cotter Paul D. , Willing Benjamin P. 
Published: July 2020

AbstractKefir consumption has been demonstrated to improve lipid and cholesterol metabolism; however, our previous study identified that benefits vary between different commercial and traditional kefir. Here, we investigate the ability of pitched culture kefir, that is, kefir produced by a small number of specific strains, to recapitulate health benefits of a traditional kefir, in a diet-induced obesity mouse model, and examine how microbial composition of kefir impacts these benefits. Eight-week-old female C57BL/6 mice were fed a high-fat diet (40 % energy from fat) supplemented with one of five kefir varieties (traditional, pitched, pitched with no Lactobacillus, pitched with no yeast and commercial control) at 2 ml in 20 g of food for 8 weeks prior to analysis of plasma and liver lipid profiles, and liver gene expression profiles related to lipid metabolism. Both traditional and pitched kefir lowered plasma cholesterol by about 35 % (P = 0·0005) and liver TAG by about 55 % (P = 0·0001) when compared with commercial kefir despite no difference in body weight. Furthermore, pitched kefir produced without either yeast or Lactobacillus did not lower cholesterol. The traditional and pitched kefir with the full complement of microbes were able to impart corresponding decreases in the expression of the cholesterol and lipid metabolism genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase, PPARγ and CD36 in the liver. These results demonstrate that traditional kefir organisms can successfully be utilised in a commercial process, while highlighting the importance of microbial interactions during fermentation in the ability of fermented foods to benefit host health.
Crustal growth event in the Cathaysia Block at 2.5 Ga: evidence from chronology and geochemistry of captured zircons in Jurassic acidic dykes
Authors: Li Shuang-Lian , Lai Jian-Qing , Xiao Wen-Zhou , Belousova Elena A. , Rushmer Tracy , Zhang Le-Jun , Ou Quan , Liu Chao-Yun 
Published: July 2020

AbstractSix acidic dykes were discovered surrounding the Laiziling pluton, Xianghualing area, in the western Cathaysia Block, South China. A number of captured zircons are found in two of these acidic dykes. By detailed U–Pb dating, Lu–Hf isotopes and trace-element analysis, we find that these zircons have ages clustered atc.2.5 Ga. Two acidic dyke samples yielded upper intersection point206U/238Pb ages of 2505 ± 42 Ma and 2533 ± 22 Ma, and weighted mean207Pb/206Pb ages of 2500 ± 30 Ma and 2535 ± 16 Ma. The majority of these zircons have high (Sm/La)N, Th/U and low Ce/Ce* ratios, indicating a magmatic origin, but some grains were altered by later hydrothermal fluid. Additionally, the magmatic zircons have high Y, U, heavy rare earth element, Nb and Ta contents, indicating that their host rocks were mainly mafic rocks or trondhjemite–tonalite–granodiorite rock series. Equally, their moderate Y, Yb, Th, Gd and Er contents also indicate that a mafic source formed in a continental volcanic-arc environment. These zircons have positive ϵHf(t) values (2.5–6.9) close to zircons from the depleted mantle, withTDM(2565–2741 Ma) andTDM2(2608–2864 Ma) ages close to their formation ages, indicating that these zircons originated directly from depleted mantle magma, or juvenile crust derived from the depleted mantle in a very short period. We therefore infer that the Cathaysia Block experienced a crustal growth event atc.2.5 Ga.
High-resolution computed tomography evaluation of congenital aural atresia – how useful is this?
Authors: Gautam R , Kumar J , Pradhan G S , Passey J C , Meher R , Mehndiratta A 
Published: July 2020

AbstractObjectiveTo depict various temporal bone abnormalities on high-resolution computed tomography in congenital aural atresia patients, and correlate these findings with auditory function test results and microtia subgroup.MethodsForty patients (56 ears) with congenital malformation of the auricle and/or external auditory canal were evaluated. Auricles were graded according to Marx's classification, divided into subgroups of minor (grades I and II) and major (III and IV) microtia. Other associated anomalies of the external auditory canal, tympanic cavity, ossicular status, oval and round windows, facial nerve, and inner ear were evaluated.ResultsMinor and major microtia were observed in 53.6 and 46.4 per cent of ears respectively. Mean hearing levels were 62.47 and 62.37 dB respectively (p = 0.98). The malleus was the most commonly dysplastic ossicle (73.3 vs 80.8 per cent of ears respectively, p = 0.53). Facial nerve (mastoid segment) abnormalities were associated (p = 0.04) with microtia subgroup (80 vs 100 per cent in minor vs major subgroups).ConclusionMicrotia grade was not significantly associated with mean hearing levels or other ear malformations, except for external auditory canal and facial nerve (mastoid segment) anomalies. High-resolution computed tomography is essential in congenital aural atresia, before management strategy is decided.
Academic achievement and schizophrenia: a systematic meta-analysis
Authors: Dickson Hannah , Hedges Emily P. , Ma Shin Y. , Cullen Alexis E. , MacCabe James H. , Kempton Matthew J. , Downs Johnny , Laurens Kristin R. 
Published: July 2020

AbstractBackgroundCognitive impairments in childhood are associated with increased risk of schizophrenia in later life, but the extent to which poor academic achievement is associated with the disorder is unclear.MethodsMajor databases were searched for articles published in English up to 31 December 2019. We conducted random-effects meta-analyses to: (1) compare general academic and mathematics achievement in youth who later developed schizophrenia and those who did not; (2) to examine the association between education level achieved and adult-onset schizophrenia; and, (3) compare general academic achievement in youth at-risk for schizophrenia and typically developing peers. Meta-regression models examined the effects of type of academic assessment, educational system, age at assessment, measurement of educational level attained, school leaving age, and study quality on academic achievement and education level among individuals with schizophrenia.ResultsMeta-analyses, comprising data of over four million individuals, found that: (1) by age 16 years, those who later developed schizophrenia had poorer general academic (Cohen's d = −0.29, p ⩽ 0.0001) and mathematics achievement (d = −0.23, p = 0.01) than those who did not; (2) individuals with schizophrenia were less likely to enter higher education (odds ratio = 0.49, p ⩽ 0.0001); and, (3) youth reporting psychotic-like experiences and youth with a family history of schizophrenia had lower general academic achievement (d = −0.54, p ⩽ 0.0001; d = −0.39, p ⩽ 0.0001, respectively). Meta-regression analyses determined no effect modifiers.DiscussionDespite significant heterogeneity across studies, various routinely collected indices of academic achievement can identify premorbid cognitive dysfunction among individuals who are vulnerable for schizophrenia, potentially aiding the early identification of risk in the population.
Altered effective connectivity from the pregenual anterior cingulate cortex to the laterobasal amygdala mediates the relationship between internet gaming disorder and loneliness
Authors: Wang Min , Zeng Ningning , Zheng Hui , Du Xiaoxia , Potenza Marc N. , Dong Guang-Heng 
Published: July 2020

AbstractBackgroundIndividual with internet gaming disorder (IGD) often experience a high level of loneliness, and neuroimaging studies have demonstrated that amygdala function is associated with both IGD and loneliness. However, the neurobiological basis underlying these relationships remains unclear.MethodsIn the current study, Granger causal analysis was performed to investigate amygdalar subdivision-based resting-state effective connectivity differences between 111 IGD subjects and 120 matched participants with recreational game use (RGUs). We further correlated neuroimaging findings with clinical measures. Mediation analysis was conducted to explore whether amygdalar subdivision-based effective connectivity mediated the relationship between IGD severity and loneliness.ResultsCompared with RGUs, IGD subjects showed inhibitory effective connections from the left pregenual anterior cingulate cortex (pACC) to the left laterobasal amygdala (LBA) and from the right medial prefrontal cortex (mPFC) to the left LBA, as well as an excitatory effective connection from the left middle prefrontal gyrus (MFG) to the right superficial amygdala. Further analyses demonstrated that the left pACC-left LBA effective connection was negatively correlated with both Internet Addiction Test and UCLA Loneliness scores, and it mediated the relationship between the two.ConclusionIGD subjects and RGUs showed different connectivity patterns involving amygdalar subdivisions. These findings support a neurobiological mechanism for the relationship between IGD and loneliness, and suggest targets for therapeutic approaches that could be used to treat IGD.
Root traits of cover crops and carbon inputs in an organic grain rotation
Authors: Amsili Joseph P. , Kaye Jason P. 
Published: July 2020

AbstractCover crops are widely used to increase the quantity of organic carbon (C) returned to the soil between cash crops. Roots play an important role in increasing soil organic carbon (SOC) levels, but the root traits that impact SOC likely vary widely among cover crop species and this variation has yet to be characterized. Recently, cover crop mixtures have expanded in popularity as a way to increase the diversity of cover crop benefits. We tested the quantity, quality and spatial distribution of roots in three monocultures and one mixture to increase our understanding of root trait variation among species, and how that variation impacts mixture design. Root cores were taken from in-row and between-row locations to a depth of 40 cm from cover crops planted after winter wheat during the 2016–2017 growing season. These samples were taken from a larger maize–soybean–winter wheat organic grain rotation experiment (2012–2018) located in central Pennsylvania, USA. Cover crop treatments included monocultures of triticale (X Triticosecale Wittmack cv. ‘Trical 815’), canola (Brassica napus L. cv. ‘Wichita’), crimson clover (Trifolium incarnatum L. cv. ‘Dixie’) and a five species mixture dominated by those three species. Additionally, cumulative carbon (C) inputs were assessed for the entire rotation to determine cover crop and cash crop root C contributions. Root biomass C vertical and horizontal distribution, root-to-shoot (R:S) ratio, and root carbon-to-nitrogen (C:N) ratio differed among cover crop treatments. Triticale produced more root biomass in the between-row space at all depth intervals compared to other cover crop treatments. The five species mixture had more total 0–5 cm and between-row 0–5 cm root biomass than crimson clover in spring 2017. Cover crop and cash crop roots increased cumulative C estimates by between 37% (crimson clover) and 46% (triticale) compared to shoot C alone. Cover crop root trait information can inform the belowground benefits from combining different species into cover crop mixtures. Crimson clover produced less root biomass, surface root biomass and between-row root biomass than other cover crop treatments. Therefore, combining crimson clover with grass and certain brassica species can improve total root biomass production, and root distribution compared to crimson clover monocultures, whereas reducing the C:N ratio of roots compared to grass species monocultures. The five species mixture led to greater cumulative carbon inputs compared to monoculture treatments, which was due to greater cover crop biomass C and its influence on the following corn crop's biomass C.
Late-life depression in sub-Saharan Africa: lessons from the Ibadan Study of Ageing
Authors: Ojagbemi A. , Bello T. , Gureje O. 
Published: July 2020

AbstractThe population surviving to old age in sub-Saharan Africa (SSA) is increasing rapidly in consonance with the rest of the world. Nevertheless, the sub-region offers unique challenges to survival across the lifespan. The determinants of health and ageing in SSA are thus likely different from those in higher income countries. The need to explore pressing epidemiological and health service challenges of older people living in SSA in the context of multiple social changes and rapid ageing of the population provided the rationale for the Ibadan Study of Ageing (ISA). This article appraises ISA findings in relation to late-life depression. It concludes that healthcare policies in SSA need to deliberately prioritise the treatment of depression and other mental health problems in late-life in order to stem the neglect of older people's mental health in the region.
Accounting for Variability in ULF Wave Radial Diffusion Models
Authors: Thompson R. L. , Watt C. E. J. , Williams P. D. 
Published: July 2020

AbstractMany modern outer radiation belt models simulate the long‐time behavior of high‐energy electrons by solving a three‐dimensional Fokker‐Planck equation for the drift‐ and bounce‐averaged electron phase space density that includes radial, pitch‐angle, and energy diffusion. Radial diffusion is an important process, often characterized by a deterministic diffusion coefficient. One widely used parameterization is based on the median of statistical ultralow frequency (ULF) wave power for a particular geomagnetic index Kp. We perform idealized numerical ensemble experiments on radial diffusion, introducing temporal and spatial variability to the diffusion coefficient through stochastic parameterization, constrained by statistical properties of its underlying observations. Our results demonstrate the sensitivity of radial diffusion over a long time period to the full distribution of the radial diffusion coefficient, highlighting that information is lost when only using median ULF wave power. When temporal variability is included, ensembles exhibit greater diffusion with more rapidly varying diffusion coefficients, larger variance of the diffusion coefficients and for distributions with heavier tails. When we introduce spatial variability, the variance in the set of all ensemble solutions increases with larger spatial scales of variability. Our results demonstrate that the variability of diffusion affects the temporal evolution of phase space density in the outer radiation belt. We discuss the need to identify important temporal and length scales to constrain variability in diffusion models. We suggest that the application of stochastic parameterization techniques in the diffusion equation may allow the inclusion of natural variability and uncertainty in modeling of wave‐particle interactions in the inner magnetosphere.
Martian Ice Revealed by Modeling of Simple Terraced Crater Formation
Authors: Martellato E. , Bramson A. M. , Cremonese G. , Lucchetti A. , Marzari F. , Massironi M. , Re C. , Byrne S. 
Published: July 2020

AbstractArcadia Planitia, a region in the northern midlatitudes of Mars, displays an uncommonly high abundance of simple craters with a concentric morphology, which is indicative of layering beneath the surface. Radar measurements suggest that the near surface layers could be made of excess water ice. In this study, we select two of these impact structures of similar size (Dc ~ 500 m), model their formation through iSALE shock physics code, and investigate the dependence of the final crater morphology on the material model parameters (cohesion and friction coefficient). Our parameter study shows that the intact and damaged cohesions of the nonporous ice play a fundamental role to obtain a good fit between our models and the topographic profiles taken from the digital terrain models in terms of crater diameter, crater wall inclination, and depth and size of the upper terrace. The central pit shape is instead controlled by the damaged friction coefficient of the basaltic crust, but it is mainly affected by projectile density and speed. Our results confirm that two layers of relatively pure water ice, each with different rheology and porosity, can explain the unique double‐terraced morphology of impact craters in Arcadia Planitia. The low values of cohesion we find for the ice might point to snowfall as emplacement mechanism in the region. The different thicknesses of the ice layers in the two crater areas seem to suggest variations in ice deposition and/or evolution history across Arcadia Planitia.
The Slab Puzzle of the Alpine‐Mediterranean Region: Insights From a New, High‐Resolution, Shear Wave Velocity Model of the Upper Mantle
Authors: El‐Sharkawy Amr , Meier Thomas , Lebedev Sergei , Behrmann Jan H. , Hamada Mona , Cristiano Luigia , Weidle Christian , Köhn Daniel 
Published: July 2020

AbstractMediterranean tectonics since the Lower Cretaceous has been characterized by a multiphase subduction and collision history with temporally and spatially variable, small‐scale plate configurations. A new shear wave velocity model of the Mediterranean upper mantle (MeRE2020), constrained by a very large set of over 200,000 broadband (8–350 s), interstation, Rayleigh wave, phase velocity curves, illuminates the complex structure and fragmentation of the subducting slabs. Phase velocity maps computed using these measurements were inverted for depth‐dependent, shear wave velocities using a stochastic particle‐swarm‐optimization (PSO) algorithm. The resulting three‐dimensional (3‐D) model makes possible an inventory of slab segments across the Mediterranean. Fourteen slab segments of 200–800 km length along‐strike are identified. We distinguish three categories of subducted slabs: attached slabs reaching down to the bottom of the model; shallow slabs of shorter length in downdip direction, terminating shallower than 300 km depth; and detached slab segments. The location of slab segments are consistent with and validated by the intermediate‐depth seismicity, where it is present. The new high‐resolution tomography demonstrates the intricate relationships between slab fragmentation and the evolution of the relatively small and highly curved subduction zones and collisional orogens characteristic of the Mediterranean realm.
Changes in Future Synoptic Circulation Patterns: Consequences for Extreme Event Attribution
Authors: Faranda Davide , Vrac Mathieu , Yiou Pascal , Jézéquel Aglaé , Thao Soulivanh 
Published: July 2020

AbstractAnthropogenic emissions can modify the frequency and intensity of extreme weather events such as cold spells, heatwaves, and heavy precipitations. A major challenge is to detect changes in the atmospheric circulation patterns associated with those extreme events. The emergence of patterns depends on the chaotic behavior of the atmospheric flow and can also be modified by anthropogenic emissions. By embedding the circulation patterns observed during selected extremes into historical climate simulations and projections based on emission scenarios, we find major changes in probability, predictability, and persistence of atmospheric patterns observed during extreme events using an analog‐based method. The results highlight the need to take into account the role of atmospheric circulation in attribution studies as future extremes will be associated with modified circulation patterns.
Anthropogenic Nitrogen‐Induced Changes in Seasonal Carbonate Dynamics in a Productive Coastal Environment
Authors: Kim Ja‐Myung , Lee Kitack , Han In‐Seong , Lee Joon‐Soo , Choi Yang‐Ho , Lee Ju Hyeon , Moon Ji‐Young 
Published: July 2020

AbstractWe estimated the seasonal extremes in pH and the aragonite saturation state (Ωarag) for the Yellow Sea over the past 30 years using recent (2015–2018) carbonate data sets, along with historical data sets of surface N and bottom water dissolved O2 concentrations. The rate of increase in surface N was assumed to determine the postbloom surface dissolved inorganic C concentration resulting from the complete utilization of N by phytoplankton, while the decrease in bottom water O2 was assumed to reflect the prebloom surface C, as a consequence of C‐rich bottom water (resulting from the oxidation of greater amounts of organic matter transported from the surface) being brought to the surface. With the increasing loads of anthropogenic N, the net community metabolism (an increase in organic matter production at the surface and subsequent remineralization at the seafloor) has lowered the seasonal amplitude of pH by 0.14 but increased the amplitude of Ωarag by 0.8.