bluuebunny/crossref_metadata_2025_split huggingface dataset:
The GUAPOS project: G31.41+0.31 Unbiased ALMA sPectral Observational Survey
Authors: Mininni C. , Beltrán M. T. , Rivilla V. M. , Sánchez-Monge A. , Fontani F. , Möller T. , Cesaroni R. , Schilke P. , Viti S. , Jiménez-Serra I. , Colzi L. , Lorenzani A. , Testi L. 
Published: October 2020

Context.One of the goals of astrochemistry is to understand the degree of chemical complexity that can be reached in star-forming regions, along with the identification of precursors of the building blocks of life in the interstellar medium. To answer such questions, unbiased spectral surveys with large bandwidth and high spectral resolution are needed, in particular, to resolve line blending in chemically rich sources and identify each molecule (especially for complex organic molecules). These kinds of observations have already been successfully carried out, primarily towards the Galactic Center, a region that shows peculiar environmental conditions.Aims.We present an unbiased spectral survey of one of the most chemically rich hot molecular cores located outside the Galactic Center, in the high-mass star-forming region G31.41+0.31. The aim of this 3mm spectral survey is to identify and characterize the physical parameters of the gas emission in different molecular species, focusing on complex organic molecules. In this first paper, we present the survey and discuss the detection and relative abundances of the three isomers of C2H4O2: methyl formate, glycolaldehyde, and acetic acid.Methods.Observations were carried out with the ALMA interferometer, covering all of band 3 from 84 to 116 GHz (~32 GHz bandwidth) with an angular resolution of 1.2′′ × 1.2′′ (~ 4400 au × 4400 au) and a spectral resolution of ~0.488 MHz (~1.3−1.7 km s−1). The transitions of the three molecules have been analyzed with the software XCLASS to determine the physical parameters of the emitted gas.Results.All three isomers were detected with abundances of (2 ± 0.6) × 10−7, (4.3−8) × 10−8, and (5.0 ± 1.4) × 10−9for methyl formate, acetic acid, and glycolaldehyde, respectively. Methyl formate and acetic acid abundances are the highest detected up to now, if compared to sources in the literature. The size of the emission varies among the three isomers with acetic acid showing the most compact emission while methyl formate exhibits the most extended emission. Different chemical pathways, involving both grain-surface chemistry and cold or hot gas-phase reactions, have been proposed for the formation of these molecules, but the small number of detections, especially of acetic acid and glycolaldehyde, have made it very difficult to confirm or discard the predictions of the models. The comparison with chemical models in literature suggests the necessity of grain-surface routes for the formation of methyl formate in G31, while for glycolaldehyde both scenarios could be feasible. The proposed grain-surface reaction for acetic acid is not capable of reproducing the observed abundance in this work, while the gas-phase scenario should be further tested, given the large uncertainties involved.
Drei Jahre Mukoviszidose-Neugeborenenscreening – wie viele und welche Kinder verpassen wir? Müssen wir noch nach CF suchen?
Authors: Mainz Jochen G. 
Published: October 2020

ZUSAMMENFASSUNGDreieinhalb Jahre nach Einführung des Neugeborenenscreenings (NGS) für Mukoviszidose ist es an der Zeit zu schauen, ob es Lücken in der CF-Diagnosestellung gibt. Können wir bei Kindern mit Symptomen der Multiorganerkrankung auf CF-Diagnostik verzichten, wenn das NGS negativ ausfiel?Bei Zusammenstellung der Daten lagen die Evaluationen für das Jahr 2017 vor, in dem in Deutschland für 160 Patienten die CF-Diagnose gestellt wurde. Sieben von ihnen (4,4 %) wiesen ein negatives CF-Screening auf, darunter 6 Patienten, mit Mekoniumileus oder Gedeihstörung.Wichtig ist auch, dass für 17,08 % der 683 Kinder mit positivem Screening unbekannt ist, ob eine Konformitätsdiagnostik erfolgte. Schlussfolgerung: Wir müssen weiter bei klinischen Zeichen einer CF konsequente Diagnostik betreiben und die Rücklaufrate von screeningpositiven Patienten verbessern.
Recurrent polyp formation with Candida tropicalis infection and otitis in a dog
Authors: Boehm Teresa M. S. A. , Parzefall Birgit , Klinger Christoph J. , Wielaender Franziska , Udraite Vovk Laura , Scabell Peter , Mueller Ralf S. 
Published: October 2020

ZusammenfassungFallbericht einer wiederkehrenden Otitis externa, media und interna durch Candida tropicalis bei einem Hund mit einem Ohrpolypen. Ein 9-jähriger Irischer Setter wies im Abstand von 7 Monaten jeweils linksseitig eine Otitis, ein Vestibulärsyndrom sowie ein Horner-Syndrom auf. Bei der ersten Episode wurde ein gutartiger Ohrpolyp extrahiert und Candida tropicalis aus dem Mittelohr kultiviert. Die neurologischen Symptome sistierten innerhalb von 7 Tagen, die Candida-Infektion war schwieriger zu behandeln. Nach 7 Monaten wurde erneut ein Polyp im Ohr festgestellt und der zytologische Befund war wieder kompatibel mit Candida tropicalis. Eine vollständige Ablation des linken Gehörgangs mit lateraler Bullaosteotomie wurde durchgeführt und eine Kultur aus dem Mittelohr bestätigte Candida tropicalis. Die Behandlung führte zur klinischen Remission. Candida tropicalis, ein zunehmend häufiger auftretendes Pathogen, sollte in Fällen rezidivierender Otitis durch Hefen in Betracht gezogen werden. Die Behandlung kann sich schwierig gestalten.
Diagnostische Zugänge im Setting Ambulante Reha
Authors: Wydra Georg , Hager Stephan , Hager Dieter 
Published: October 2020

ZusammenfassungDie ambulante Rehabilitation stellt eine wichtige Säule in der gesundheitlichen Versorgung der Bevölkerung dar. Die Internationalen Klassifikation der Funktionsfähigkeit, Behinderung und Gesundheit (ICF) der WHO steht seit zwei Jahrzehnten als theoretischer Bezugsrahmen zur Systematisierung der Funktionsstörungen, der Behandlungsstrategien und der Assessmentverfahren zur Verfügung. Aus bewegungstherapeutischer Sicht ist es naheliegend, die Mobilität in das Zentrum der Betrachtungen zu rücken.Es wird ein theoretisches Rahmenmodell vorgestellt, das am Beispiel der Rehabilitation nach Ruptur des vorderen Kreuzbandes aufzeigt, wie ausgewählte Assessmentverfahren in Abhängigkeit von den Kategorien der ICF (Strukturen, Funktionen, Mobilität und Partizipation) und den verschiedenen Phasen der Rehabilitation (Alltag, Sport und Wettkampf) sinnvoll zu einer Assessmentbatterie kombiniert werden können. Diese Betrachtungsweise kann auch auf andere Funktionsstörungen und Behinderungen übertragen werden.
Testverfahren in der stationären Rehabilitation
Authors: Köppel Maximilian , Hamacher Dieter 
Published: October 2020

ZusammenfassungMessen in der stationären Rehabilitation wird nicht nur vom Gesetzgeber gefordert, es ist auch integral für die Therapieplanung, deren Kontrolle sowie Ergebnisevaluation. Hier-bei ist es notwendig, dass der Testleiter ein fundiertes Verständnis dessen besitzt, was gemessen werden soll; sowohl im Allgemeinen wie auch bei möglichen Abweichungen hiervon im Einzelfall. Hierfür muss zunächst geklärt werden, in welcher bewegungswissenschaftlichen Betrachtungsweise das gemessene Merkmal verortet werden kann und welche internen Prozesse und Gesetzmäßigkeiten diesem Merkmal zugrunde liegen. Einen Messapparat bedienen zu können, stellt daher lediglich eine notwendige Voraussetzung für die Messung dar, gewährleistet aber nicht den Transfer der Messergebnisse in die diagnostische oder therapeutische Praxis.
Evaluation of the U.S. Adherence Questionnaires VERITAS-PRO and VERITAS-PRN for Use in Patients with Hemophilia in the German Healthcare System
Authors: von Mackensen Sylvia , Douma Yves , Halimeh Susan 
Published: October 2020

AbstractAim Since the U.S. adherence instruments VERITAS-PRO and VERITAS-PRN were developed in another healthcare system, we assumed that they are not appropriate for the German solidarity healthcare system. This study aims to evaluate the relevance of these instruments for the German healthcare system both by people with hemophilia (PWH) and by healthcare professionals (HCP).Methods A total of 50 PWH (23 adult hemophilia patients and 27 parents of children with hemophilia) and 25 HCP rated the relevance of the single items of the VERITAS-PRO and VERITAS-PRN on a 5-point Likert scale. In addition, both groups were asked to make suggestions for additional adherence questions. To investigate the relevance of these instruments, the accordance between the raters' evaluations was determined calculating the content validity index (CVI) and the content validity ratio (CVR) based on the critical values of the CVR (CVRcritical) to exclude chance and subjectivity.Results CVI (CVR) calculations revealed three (5) “very important” items for PWH and six (11) items for HCP. Only two (3) “very important” items were evaluated by both groups. Four domains were considered not important by both groups. Six PWH made 14 suggestions and 14 HCP made 24 suggestions for additional adherence questions.Conclusion VERITAS-PRO and VERITAS-PRN have only very limited benefits for the German healthcare system. Since nonadherence has a great impact on the morbidity of PWH and on the costs for the healthcare system, there is a need for adherence instruments that are adapted to the specific needs of PWH in the German healthcare system.
Factors affecting length of stay in Fournier’s gangrene: a retrospective analysis of 10 years’ data
Authors: Eksi Mithat , Arikan Yusuf , Simsek Abdulmuttalip , Ozdemir Osman , Karadag Serdar , Gurbuz Necati , Sahin Selcuk , Tasci Ali Ihsan 
Published: October 2020

Abstract
Background We aimed to investigate the parameters that have an effect on the length of stay and mortality rates of patients with Fournier’s gangrene.
Material and Methods A retrospective review was performed on 80 patients who presented to the emergency department and underwent emergency debridement with the diagnosis of Fournier’s gangrene between 2008 and 2017. The demographic and clinical characteristics, length of stay, Fournier’s Gangrene Severity Index score, cystostomy and colostomy requirement, additional treatment for wound healing and the mortality rates of the patients were evaluated.
Results Of the 80 patients included in the study, 65 (81.2 %) were male and 15 (18.7 %) female. The most common comorbidity was diabetes mellitus. The mean time between onset of complaints and admission to hospital was 4.6 ± 2.5 days. As a result of the statistical analyses, it was found that Fournier’s Gangrene Severity Index score, hyperbaric oxygen therapy, negative pressure wound therapy and the presence of sepsis and colostomy were significantly positively correlated with length of stay. Also it was found that the Fournier’s Gangrene Severity Index score, administration of negative pressure wound therapy and the presence of sepsis were correlated with mortality.
Conclusion Fournier’s gangrene is a mortal disease and an emergency condition. With the improvements in Fournier’s gangrene disease management, mortality rates are decreasing, but long-term hospital stay has become a new problem. Knowing the values predicting length of stay and mortality rates can allow for patient-based treatment and may be useful in treatment choice.
Fractionated Radiosurgical Treatment of Intracerebral Schwannoma: A Case Report and Literature Review
Authors: Tokarev Alexey , Rak Viacheslav , Stepanov Valentin , Zuev Sergey , Evdokimova Olga , Viktorova Olga , Rozhnova Elizabeth 
Published: October 2020

AbstractIntracranial schwannomas (ICS) unrelated to the cranial nerves are extremely rare; around 70 cases have been reported worldwide. The available literature consists of case reports and small series that present variable characteristics distinguishing these lesions. Brain parenchyma schwannomas are typically benign tumors with currently unknown origins. Diagnosis of intraparenchymal schwannoma is almost never made preoperatively. The management of these tumors usually consists of gross total resection, chemotherapy, and radiotherapy in cases of recurrence. The authors present a case of fractionated Gamma Knife radiosurgical treatment of intracerebral schwannoma following partial microsurgical resection.
Effects of Blatta orientalis on Treatment of Bronchial Asthma: A Prospective, Non-Randomised, Open-Label, Observational Study
Authors: Ram Hanuman , Choudhary Prasoon , Dewan Deepti , Kumar Arvind 
Published: October 2020

Abstract
Background Bronchial asthma is a globally significant non-communicable disease with major public health consequences for both children and adults, including high morbidity, and relatively low mortality compared with other chronic diseases. It is a chronic disorder that compels the patient to take lifelong medications including bronchodilators.
Aim This study was undertaken to ascertain the effects of Blatta orientalis in centesimal potency on the treatment of bronchial asthma assessed by spirometry and Asthma Control Questionnaire (ACQ) Score.
Method A prospective, non-randomised, open-label, observational study was conducted at Dr. MPK Homoeopathic Medical College, Hospital & Research Centre, Jaipur, Rajasthan, from 2015 to 2016. Patients between 5 and 80 years of age suffering from dyspnoea, cough with expectoration and wheezing were screened. The convenience sampling technique was used to enrol 120 patients, after fulfilling the inclusion and exclusion criteria of the study. The patients of Bronchial asthma were treated with potentized Blatta orientalis for 6 months. Patients were diagnosed and assessed on the basis of the ACQ Score by Elizabeth Junipers and spirometry findings. Blatta orientalis was prescribed to all patients in increasing potency from 30C. The paired t-test was applied to calculate the statistical significance of the study.
Result Out of 120 patients, 100 had completed the study with follow-up of 6 months. A significant difference was found in pre- and post-treatment spirometry—that is, forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) ratio—from baseline to 6 months (mean ± standard deviation [SD]: –10.27 ± 4.95; 95% confidence interval [CI]: –11.25 to –9.28; p = 0.00001). Also, significant difference was seen in the ACQ Score from baseline to 6 months (mean ± SD: 19.44 ± 8.69; 95% CI: 17.71–21.16; p = 0.00001).
Conclusion The study findings are encouraging enough to prescribe Blatta orientalis in potency in cases of bronchial asthma. Further systematic replication is required. Conducted as randomised controlled trials with long-term follow-ups for definite conclusions.
Application of Human Factors Methods to Understand Missed Follow-up of Abnormal Test Results
Authors: Rogith Deevakar , Satterly Tyler , Singh Hardeep , Sittig Dean F. , Russo Elise , Smith Michael W. , Roosan Don , Bhise Viraj , Murphy Daniel R. 
Published: October 2020

Abstract
Objective This study demonstrates application of human factors methods for understanding causes for lack of timely follow-up of abnormal test results (“missed results”) in outpatient settings.
Methods We identified 30 cases of missed test results by querying electronic health record data, developed a critical decision method (CDM)-based interview guide to understand decision-making processes, and interviewed physicians who ordered these tests. We analyzed transcribed responses using a contextual inquiry (CI)-based methodology to identify contextual factors contributing to missed results. We then developed a CI-based flow model and conducted a fault tree analysis (FTA) to identify hierarchical relationships between factors that delayed action.
Results The flow model highlighted barriers in information flow and decision making, and the hierarchical model identified relationships between contributing factors for delayed action. Key findings including underdeveloped methods to track follow-up, as well as mismatches, in communication channels, timeframes, and expectations between patients and physicians.
Conclusion This case report illustrates how human factors–based approaches can enable analysis of contributing factors that lead to missed results, thus informing development of preventive strategies to address them.
Complicated Diverticular Disease
Authors: Coakley Kathleen M. , Davis Bradley R. , Kasten Kevin R. 
Published: October 2020

AbstractThe modern management of colonic diverticular disease involves grouping patients into uncomplicated or complicated diverticulitis, after which the correct treatment paradigm is instituted. Recent controversies suggest overlap in management strategies between these two groups. While most reports still support surgical intervention for the treatment of complicated diverticular disease, more data are forthcoming suggesting complicated diverticulitis does not merit surgical resection in all scenarios. Given the significant risk for complication in surgery for diverticulitis, careful attention should be paid to patient and procedure selection. Here, we define complicated diverticulitis, discuss options for surgical intervention, and explain strategies for avoiding operative pitfalls that result in early and late postoperative complications.
User-Centered Clinical Display Design Issues for Inpatient Providers
Authors: Lasko Thomas A. , Owens David A. , Fabbri Daniel , Wanderer Jonathan P. , Genkins Julian Z. , Novak Laurie L. 
Published: October 2020

AbstractBackground Suboptimal information display in electronic health records (EHRs) is a notorious pain point for users. Designing an effective display is difficult, due in part to the complex and varied nature of clinical practice.Objective This article aims to understand the goals, constraints, frustrations, and mental models of inpatient medical providers when accessing EHR data, to better inform the display of clinical information.Methods A multidisciplinary ethnographic study of inpatient medical providers.Results Our participants' primary goal was usually to assemble a clinical picture around a given question, under the constraints of time pressure and incomplete information. To do so, they tend to use a mental model of multiple layers of abstraction when thinking of patients and disease; they prefer immediate pattern recognition strategies for answering clinical questions, with breadth-first or depth-first search strategies used subsequently if needed; and they are sensitive to data relevance, completeness, and reliability when reading a record.Conclusion These results conflict with the ubiquitous display design practice of separating data by type (test results, medications, notes, etc.), a mismatch that is known to encumber efficient mental processing by increasing both navigation burden and memory demands on users. A popular and obvious solution is to select or filter the data to display exactly what is presumed to be relevant to the clinical question, but this solution is both brittle and mistrusted by users. A less brittle approach that is more aligned with our users' mental model could use abstraction to summarize details instead of filtering to hide data. An abstraction-based approach could allow clinicians to more easily assemble a clinical picture, to use immediate pattern recognition strategies, and to adjust the level of displayed detail to their particular needs. It could also help the user notice unanticipated patterns and to fluidly shift attention as understanding evolves.
Characterization of New Monoclonal PF4-Specific Antibodies as Useful Tools for Studies on Typical and Autoimmune Heparin-Induced Thrombocytopenia
Authors: Vayne Caroline , Nguyen Thi-Huong , Rollin Jérôme , Charuel Noémie , Poupon Anne , Pouplard Claire , Normann Nicole , Gruel Yves , Greinacher Andreas 
Published: October 2020

Abstract
Background Heparin-induced thrombocytopenia (HIT) is typically caused by platelet-activating immunoglobulin G (IgG) antibodies (Abs) against platelet factor 4 (PF4) complexed with heparin (H). Much less frequent “autoimmune” HIT is distinguished from typical HIT by platelet activation without heparin and the presence of both anti-PF4/H and anti-PF4 IgG. We developed three murine monoclonal anti-PF4 Abs with a human Fc-part, 1E12, 1C12, and 2E1, resembling autoimmune HIT Abs.
Objectives To characterize 1E12, 1C12, and 2E1 in comparison to the heparin-dependent monoclonal anti-PF4/H Abs 5B9 and KKO, and polyclonal Abs from patients with typical HIT (group-2) and autoimmune HIT (group-3).
Methods Interactions of Abs with PF4 and PF4/H were studied by enzyme-linked-immunosorbent assay, single-molecule force spectroscopy, isothermal titration calorimetry, and dynamic light scattering. Serotonin release assay and heparin-induced platelet activation assay were used to assess platelet activation. The binding sites of monoclonal Abs on PF4 were predicted in silico (MAbTope method).
Results 1C12, 1E12, and 2E1 displayed higher affinity for PF4/H complexes than 5B9 and KKO, comparable to human group-3 Abs. Only 1C12, 1E12, 2E1, and group-3 Abs formed large complexes with native PF4, and activated platelets without heparin. The predicted binding sites of 1C12, 1E12, and 2E1 on PF4 differed from those of KKO and 5B9, but were close to each other. 2E1 exhibited unique bivalent binding, involving its antigen recognition site to PF4 and charge-dependent interactions with heparin.
Conclusion 1C12, 1E12, and 2E1 are tools for studying the pathophysiology of autoimmune HIT. 2E1 provides evidence for a new binding mechanism of HIT Abs.
COVID-19 screening center models in South Korea
Authors: Kim Ji Eon , Lee Ji Ho , Lee Hocheol , Moon Seok Jun , Nam Eun Woo 
Published: October 2020

AbstractIn a recent report, the British Broadcasting Company (BBC) introduced South Korea’s measures to manage COVID-19 as role model for the world. Screening centers serve as frontiers for preventing community transmission of infectious diseases. COVID-19 screening centers in Korea operate 24 h a day, always open for individuals with suspected COVID-19 symptoms. South Korea concentrated COVID-19 screening centers around cities with high population density. Advanced screening centers (models C, D, and E) proved more effective and efficient in the prevention of COVID-19 than the traditional screening centers (models A and B). Particularly, screening centers at Incheon Airport in South Korea prevent transmission through imported cases effectively. It will be important elsewhere, as in South Korea, to establish an infectious disease delivery system that can lead to 'Test-Treat-Track' using an adequate model of screening centers.
The Full Transfer/Full Access model and L3 cognitive states
Authors: Schwartz Bonnie D. , Sprouse Rex A. 
Published: October 2020

Abstract
This paper offers an overview of current models of third language (L3) acquisition, classifying each as a Wholesale
Transfer model or as a Piecemeal Transfer model. We discuss what we consider to be some conceptual and empirical problems for the
Piecemeal Transfer approaches and then discuss some advantages we see in Wholesale Transfer. Next, we home in on Wholesale
Transfer models, arguing that one of them in particular seems to us to be the most promising, viz., the Typological Primacy Model
(TPM – e.g., Rothman, 2011, 2015). Finally,
we take up some open questions associated with the TPM and suggest some possible directions for future L3 research.
The weak B, B

s
and B

c
decays to radially excited states
Authors: Zhou Tian , Wang Tianhong , Jiang Yue , Huo Lei , Wang Guo-Li 
Published: October 2020

Abstract
Recently, many new excited states of heavy mesons have been discovered, especially radially excited states. It draws interest to study the production processes of these states from the ground b-flavored mesons. In this paper, we use the improved Bethe-Salpeter method to study the semi-leptonic and non-leptonic decays of B, B

s
, and B

c
mesons. The calculations mostly focus on the decay channels with the radially excited 2S and 3S final states. We find that many channels have branching ratios up to 10−4, which are within the detection accuracy of current experiments.