bluuebunny/crossref_metadata_2025_split huggingface dataset:
Persistence of Racial Inequities in Receipt of Influenza Vaccination Among Nursing Home Residents in the United States
Authors: Bardenheier Barbara H , Baier Rosa R , Silva Joe B , Gravenstein Stefan , Moyo Patience , Bosco Elliott , Ogarek Jessica , van Aalst Robertus , Chit Ayman , Loiacono Matthew , Zullo Andrew R 
Published: September 2020

Abstract

Background
We sought to determine if racial differences in influenza vaccination among nursing home (NH) residents during the 2008–2009 influenza season persisted in 2018–2019.

Methods
We conducted a cross-sectional study of NHs certified by the Centers for Medicare & Medicaid Services during the 2018–2019 influenza season in US states with ≥1% Black NH residents and a White–Black gap in influenza vaccination of NH residents (N = 2 233 392) of at least 1 percentage point (N = 40 states). NH residents during 1 October 2018 through 31 March 2019 aged ≥18 years and self-identified as being of Black or White race were included. Residents’ influenza vaccination status (vaccinated, refused, and not offered) was assessed. Multilevel modeling was used to estimate facility-level vaccination status and inequities by state.

Results
The White–Black gap in influenza vaccination was 9.9 percentage points. In adjusted analyses, racial inequities in vaccination were more prominent at the facility level than at the state level. Black residents disproportionately lived in NHs that had a majority of Blacks residents, which generally had the lowest vaccination. Inequities were most concentrated in the Midwestern region, also the most segregated. Not being offered the vaccine was negligible in absolute percentage points between White residents (2.6%) and Black residents (4.8%), whereas refusals were higher among Black (28.7%) than White residents (21.0%).

Conclusions
The increase in the White–Black vaccination gap among NH residents is occurring at the facility level in more states, especially those with the most segregation.
The Impact of Aging on Spatial Abilities in Deaf Users of a Sign Language
Authors: Luna Stéphanie , Joubert Sven , Blondel Marion , Cecchetto Carlo , Gagné Jean-Pierre 
Published: September 2020

Abstract
Research involving the general population of people who use a spoken language to communicate has demonstrated that older adults experience cognitive and physical changes associated with aging. Notwithstanding the differences in the cognitive processes involved in sign and spoken languages, it is possible that aging can also affect cognitive processing in deaf signers. This research aims to explore the impact of aging on spatial abilities among sign language users. Results showed that younger signers were more accurate than older signers on all spatial tasks. Therefore, the age-related impact on spatial abilities found in the older hearing population can be generalized to the population of signers. Potential implications for sign language production and comprehension are discussed.
An assessment of adherence to CARE reporting standards by case reports published in European Heart Journal – Case Reports in 2018
Authors: Freer Rosie , Rowett Alexandra , Camm C Fielder 
Published: September 2020

AbstractBackgroundCase reports are subject to significant variation in their content, and the absence of pertinent case details can limit their benefit to the medical community. To aid this, a reporting standard (CARE) has been developed. Case reports published in European Heart Journal – Case reports (EHJ-CR) are subject to specific checks by editors to confirm compliance with the CARE reporting standard. However, a degree to which case reports published by EHJ-CR comply with the CARE reporting standards has not been established.MethodsCase reports published in EHJ-CR during 2018 were reviewed for compliance with the CARE reporting standards. Two authors assessed each article for compliance with each of the 31 criteria.ResultsIn 2018, 130 case reports/series were published by EHJ-CR. The median number of CARE criteria achieved by each article was 21 (interquartile range 21–25) out of 31. CARE criteria with the highest adherence were timeline inclusion, a clear and well-referenced discussion, and declaration of competing interests, all present in 100% of articles. In contrast, some aspects were poorly adhered to including patient perspective, and details of funding sources. There was no difference in overall compliance with aspects of the CARE standard between diagnostic and interventional case reports. However, lower compliance was seen for the discussion of diagnostic challenges in interventional studies (19%), when compared to diagnostic studies (44%). The continent of authorship and month submitted did not affect CARE adherence.ConclusionsThere was good compliance with the CARE reporting standards by case reports published in EHJ-CR. A number of specific areas for improvement have been identified which will be considered by the editorial board of EHJ-CR.
The drivers of Italian exports and product market entry: 1862–1913
Authors: Timini Jacopo 
Published: September 2020

AbstractBetween its unification and WWI, Italy’s changing export composition echoed its economic transformation. In this paper, I decompose Italian export growth in its margins and then analyze the determinants of Italian exports and product market entry (and exit). To do so, I use two different databases (aggregate and product-level bilateral trade data) and methodologies (gravity and logit models). Besides confirming some well-known empirical and historical facts for the Italian case (gravity variables hold; trade follows a Heckscher–Olhin pattern), the regression results offer a new perspective on two distinctive features of its history: trade policy and emigration. These two factors are positively associated with Italian exports and product market entry. These findings also have additional implications for the role of emigration on the course of the Italian economy: accounting for the trade channel, its overall effect may be larger than previously thought.
Sugar Maple, Red Maple, and Yellow Birch Growth and Mortality in Even-Aged Adirondack Northern Hardwoods
Authors: Nyland Ralph D , Bevilacqua Eddie , Ruff David A , Kiernan Diane H 
Published: September 2020

AbstractTree diameter growth models for northern hardwoods commonly used large data sets representing a composite of stands with varying management histories, structural characteristics, and age distributions. Yet common predictor variables like diameter can show differences in growth patterns for stands with different age structures and management histories. To address that, we modeled growth and mortality for sugar maple, red maple, and yellow birch in thinned even-aged Adirondack northern hardwoods. Findings indicate that change in diameter depends on initial diameter for sugar maple, with the rate decreasing exponentially from the largest size class to the smallest. Initial diameter did not prove significant with red maple and yellow birch in these thinned stands, perhaps because of the limited sample of trees of small diameter. Stand relative density and time since treatment affected growth for all three species. Those variables also proved significant for predicting mortality of sugar maple. Analyses revealed fewer losses of sugar and red maples among the larger diameter classes, but no relationship with diameter for yellow birch. Plot relative density did not affect mortality with red maple, but time after thinning had a significant effect on survival of all species.
Model Predictions of Postwildfire Woody Fuel Succession and Fire Behavior Are Sensitive to Fuel Dynamics Parameters
Authors: Kennedy Maureen C , Johnson Morris C , Harrison Sarah C 
Published: September 2020

Abstract
Computer models used to predict forest and fuels dynamics and wildfire behavior inform decisionmaking in contexts such as postdisturbance management. It is imperative to understand possible uncertainty in model predictions. We evaluated sensitivity of the Fire and Fuels Extension to the Forest Vegetation Simulator predictions to parameters that determine dynamics of standing dead trees (snags) and surface woody fuels. Predicted peak coarse and fine woody fuels were not sensitive to the decomposition rate of snags but were sensitive to decomposition rate of surface fuels regardless of initial snag density. Predictions of coarse woody fuel were sensitive to the snag fall rate when there was a higher initial density of snags. Fire behavior predictions were most sensitive to whether stylized fuel models or modeled fuels were used in calculations. When modeled fuels were used, fire behavior predictions were sensitive to the decomposition rate of surface fuels. Although this analysis does not inform the accuracy of model predictions, it does show where there is potential uncertainty in predictions of woody fuels succession and associated fire behavior. It is likely that any model that predicts postdisturbance fuel succession will also be sensitive to parameters that control snag dynamics and fuel decomposition.
Mixture of Triclopyr and Imazapyr More Effective than Triclopyr Alone for Hardwood Forest Stand Improvement
Authors: Turner Mark A , Gulsby William D , Harper Craig A 
Published: September 2020

AbstractTreatment of individual trees in hardwood stands typically is conducted with herbicides that have no soil activity, such as triclopyr. However, triclopyr is not effective on some tree species. Applying a mixture of triclopyr and imazapyr would broaden the spectrum of species controlled, but nontarget mortality may be problematic as imazapyr may affect other trees through soil activity. We applied herbicide via girdle-and-spray as part of a forest stand improvement treatment in four upland hardwood stands in the Upper Coastal Plain of Alabama. We compared effects of using triclopyr alone with a mixture of triclopyr and imazapyr 18 months posttreatment. Only one untreated sweetgum (Liquidambar styraciflua) out of 440 trees was killed in the stands treated with the herbicide mixture (0.5 percent nontarget mortality rate). Nontarget mortality did not differ between treatments. However, the herbicide mixture controlled hickory (Carya spp.) and sourwood (Oxydendrum arboreum) better than triclopyr alone, with 56 percent of hickory treated with triclopyr still alive 18 months later, compared with 0 percent of hickory treated with the mixture. Our results indicate a mixture of triclopyr and imazapyr provides better control than triclopyr alone, and there is minimal risk to nontarget tree species in hardwood stands when used according to label recommendations.
Don't Mention the War versus Escalating Commitment: Political Party Responses to Military Casualties
Authors: Kuijpers Dieuwertje , Schumacher Gijs 
Published: September 2020

AbstractDo political parties change their position when military casualties increase? Several studies demonstrate that once military casualties increase, public support for sometimes even the government itself declines. With this potential backlash, once governing parties are faced with military casualties, do they (1) maintain that intervention was the “right thing” to do and even escalate their commitment by becoming even more pro-military or (2) try to avoid the blame and downplay the issue, i.e., “not mentioning the war”? And do the opposition parties become more negative or more positive about the military? To evaluate this, we measure the position on military issues in parties’ election manifestoes. Our dataset comprises 326 party policy changes in eleven Organisation for Economic Co-operation and Development (OECD) countries and focuses on post-Cold War military interventions. By using pooled time-series cross-sectional analysis, we find that opposition parties and governing parties respond differently. Generally, governing parties become more negative in their manifesto and opposition parties more positive. We also demonstrate important differences between party families and pre/post-9/11. Our analyses show that whether political parties change policy course once confronted with negative outcomes depends on their position in office, and also the direction in which they change policy depends on political ideology.
Patterns of Political Ideology and Security Policy
Authors: Haesebrouck Tim , Mello Patrick A 
Published: September 2020

AbstractRecent studies on political ideology suggest the existence of partisan divides on matters of foreign and security policy, challenging the notion that “politics stops at the water's edge.” However, when taken as a whole, extant work provides decidedly mixed evidence of party-political differences outside domestic politics. This article first conducts a systematic empirical analysis of the relationship between parties’ left–right positions and their general attitude toward peace and security missions, which suggests that right-leaning parties tend to be more supportive of military operations. Yet, the results also show that the empirical pattern is curvilinear: centrist and center–right parties witness the highest level of support for military missions, while parties on both ends of the political spectrum show substantially less support. The second part of our analysis examines whether the stronger support of rightist parties for peace and security missions translates into a greater inclination of right-wing governments to actually deploy forces for military operations. Strikingly, our results suggest that leftist governments were actually more inclined to participate in operations than their right-leaning counterparts. The greater willingness of left-wing executives to deploy military forces is the result of their greater inclination to participate in operations with inclusive goals.
Mapping Parties’ Positions on Foreign and Security Issues in the EU, 2009–2014
Authors: Cicchi Lorenzo , Garzia Diego , Trechsel Alexander H 
Published: September 2020

AbstractThis article offers a comparative analysis of parties’ position on foreign and security issues in the EU28 across the EP elections of 2009 and 2014. First, we map the position of the parties on selected foreign policy and security issues in both 2009 and 2014. Second, we measure the extent to which party positions on such issues remained stable across these five years. Third, we offer an explanatory analysis of the competing factors potentially affecting changes in parties’ position. By means of multivariate regression models, we test the effect of party ideology, overall attitude toward EU integration, and structural factors at the party level in view of answering the following question: Do parties hold “genuine” positions over EU foreign and security policy, or are they rather due to their relatively more encompassing attitude toward EU integration? The data come from two transnational voting advice applications developed during the 2009 and 2014 European elections campaigns, respectively.
The Party Politics of Foreign and Security Policy
Authors: Raunio Tapio , Wagner Wolfgang 
Published: September 2020

AbstractThe positions of political parties in various foreign policy questions and how such ideological stances matter in foreign and security policy decision-making remain largely unexplored beyond the specific case of the United States. Reviewing the “state of the art” in foreign policy analysis and comparative politics, this introductory article discusses the changing nature of both international politics and party systems and cleavages in Europe and beyond. It puts forward reasons why we should see different patterns of coalitions and party behavior in security policy, on the one hand, and in international trade and foreign aid, on the other hand. The articles in this Special Issue have been deliberately chosen to capture different elements of “partyness,” from analyzing party positions to actual behavior by legislatures and governments to transnational party networks. Our main argument is that there are genuine ideological differences between political parties and that the impact of these competing ideologies is also discernible in foreign policy decision-making.
A Model-Driven Quantitative Analysis of Retrotransposon Distributions in the Human Genome
Authors: Riba Andrea , Fumagalli Maria Rita , Caselle Michele , Osella Matteo 
Published: September 2020

Abstract
Retrotransposons, DNA sequences capable of creating copies of themselves, compose about half of the human genome and played a central role in the evolution of mammals. Their current position in the host genome is the result of the retrotranscription process and of the following host genome evolution. We apply a model from statistical physics to show that the genomic distribution of the two most populated classes of retrotransposons in human deviates from random placement, and that this deviation increases with time. The time dependence suggests a major role of the host genome dynamics in shaping the current retrotransposon distributions. Focusing on a neutral scenario, we show that a simple model based on random placement followed by genome expansion and sequence duplications can reproduce the empirical retrotransposon distributions, even though more complex and possibly selective mechanisms can have contributed. Besides the inherent interest in understanding the origin of current retrotransposon distributions, this work sets a general analytical framework to analyze quantitatively the effects of genome evolutionary dynamics on the distribution of genomic elements.
Cynical Hostility and Loneliness in Older Adult Married Couples: An Indirect Effect Through Friendships
Authors: Segel-Karpas Dikla , Ermer Ashley 
Published: September 2020

Abstract

Objectives
Cynical hostility is a cognitive schema according to which people cannot be trusted, and it has associations with individuals’ loneliness. The present study takes a dyadic approach to examine whether cynical hostility is related to one’s own and their spouse’s loneliness. We further explore whether friendship factors serve as a mediator between individuals’ and spouses’ cynical hostility and loneliness.

Method
We used 2 waves of the Health and Retirement Study (N = 1,065 couples) and Actor-Partner Interdependence Models (APIMs) with mediation to examine the proposed model. Mediation was tested with the construction of path models and significance levels were reached using bootstrapping.

Results
For both husbands and wives, cynical hostility was significantly associated with loneliness. Husband’s loneliness was also significantly associated with his wife’s cynical hostility, but wife’s loneliness was not associated with her husband’s cynical hostility. We further found that the association between wife’s own cynical hostility and loneliness was mediated by lower levels of contact with, and support from friends. Friendship factors did not serve as mediators for husbands.

Discussion
Husbands and wives who have higher levels of cynical hostility may be more vulnerable to loneliness. High levels of cynical hostility in women may be related to deficits in their quantity and quality of friendship, and thus be associated with loneliness. Men who are married to women with a higher level of cynical hostility may experience increased loneliness, but this relationship is not explained by men’s friendships.
Structure, Dynamics, and Interactions of GPI-Anchored Human Glypican-1 with Heparan Sulfates in a Membrane
Authors: Dong Chuqiao , Choi Yeol Kyo , Lee Jumin , Zhang X Frank , Honerkamp-Smith Aurelia , Widmalm Göran , Lowe-Krentz Linda J , Im Wonpil 
Published: September 2020

Abstract
Glypican-1 and its heparan sulfate (HS) chains play important roles in modulating many biological processes including growth factor signaling. Glypican-1 is bound to a membrane surface via a glycosylphosphatidylinositol (GPI)-anchor. In this study, we used all-atom molecular modeling and simulation to explore the structure, dynamics, and interactions of GPI-anchored glypican-1, three HS chains, membranes, and ions. The folded glypican-1 core structure is stable, but has substantial degrees of freedom in terms of movement and orientation with respect to the membrane due to the long unstructured C-terminal region linking the core to the GPI-anchor. With unique structural features depending on the extent of sulfation, high flexibility of HS chains can promote multi-site interactions with surrounding molecules near and above the membrane. This study is a first step toward all-atom molecular modeling and simulation of the glycocalyx, as well as its modulation of interactions between growth factors and their receptors.
Association of Early Postinduction Adalimumab Exposure With Subsequent Clinical and Biomarker Remission in Children with Crohn’s Disease
Authors: Rinawi Firas , Ricciuto Amanda , Church Peter C , Frost Karen , Crowley Eileen , Walters Thomas D , Griffiths Anne M 
Published: September 2020

Abstract

Background
Data on the association between early postinduction serum adalimumab (ADA) trough levels (TLs) and objective outcomes are scarce. The aim of this study was to investigate whether early ADA TLs at weeks 4 and 8 are associated with clinical and biomarker remission at week 24 in pediatric Crohn’s disease (CD).

Methods
Adalimumab TLs at weeks 4 and 8 were prospectively measured in anti-TNF-naïve children initiating treatment with ADA monotherapy for luminal inflammatory CD. The primary outcome was combined clinical and biomarker remission at week 24, defined as achieving steroid-free clinical remission (Pediatric CD activity index &lt;10) and biomarker remission (fecal calprotectin &lt;250 µg/g and CRP &lt;5 µg/mL).

Results
Among 65 patients, 39 (60%) achieved combined clinical/biomarker remission at week 24 without dose escalation. Adalimumab TLs at both weeks 4 and 8 were significantly higher in remitters vs nonremitters at week 24 (P &lt; 0.001 and P = 0.002, respectively). Adalimumab levels at weeks 4 and 8 were good predictors of combined clinical/biomarker remission at week 24 (area under the curve, 0.887, 95% CI, 0.798–0.942; and area under the curve, 0.761, 95% CI, 0.632–0.899, respectively). The best ADA TL cutoffs at weeks 4 and 8 for predicting clinical/biomarker remission at week 24 were 22.5 µg/mL (80% sensitivity, 90% specificity, positive likelihood ratio [LR+] 8.0, negative LR [LR-] 0.2) and 12.5 µg/mL (94% sensitivity, 60% specificity, LR+ 2.4, LR- 0.1), respectively. Higher induction doses per m2 correlated positively with TLs at weeks 4 and 8.

Conclusion
Greater early ADA exposure is associated with superior clinical/biomarker outcomes at week 24.
Cardiovascular Risk Assessment and Impact of Medications on Cardiovascular Disease in Inflammatory Bowel Disease
Authors: Sinh Preetika , Cross Raymond 
Published: September 2020

Abstract
There is increased risk of cardiovascular disease in patients with chronic inflammatory disorders such as rheumatoid arthritis, psoriatic arthritis, and systemic lupus erythematosus. Studies have shown association between cardiovascular disease (eg, myocardial infarction, heart failure, stroke) and inflammatory bowel disease. Medications such as infliximab and adalimumab (monoclonal antibodies to tumor necrosis factor α) may help decrease the inflammatory burden and cardiovascular risk; however, there have been reports of hypertriglyceridemia and worsening of moderate to severe heart failure with these medications. Janus kinase inhibitors, such as tofacitinib, have been associated with hyperlipidemia and thromboembolism. We aim to discuss clinical and imaging modalities to assess cardiovascular risk in inflammatory bowel disease patients and review the role of various medications with respect to cardiovascular disease in this population.