bluuebunny/crossref_metadata_2025_split huggingface dataset:
A survey of pregnant women about their preferences for prenatal tests with different characteristics
Authors: Баранова Е.Е. , Заяева Е.Е. , Жученко Л.А. , Щелыкалина С.П. , Ижевская В.Л. 
Published: November 2020

Проанализировано мнение 800 беременных женщин, проходящих ранний пренатальный скрининг (РПС) врожденных пороков развития и хромосомных аномалий у плода, относительно различных характеристик пренатальных тестов Проведенный опрос позволит сравнить результаты с другими странами, где НИПТ используется в РПС, и выработать собственные рекомендации.
Relatively different characteristics of prenatal tests, the opinion of 800 pregnant women undergoing early prenatal screening (EPS) of congenital malformations and chromosomal abnormalities in the fetus was analyzed. The survey will allow you to compare the results with other countries where NIPT is used in the EPS, and to develop our own recommendations.
Modern opportunities and approaches to diagnosis of genetic male infertility
Authors: Сорокина Т.М. , Курило Л.Ф. , Черных В.Б. 
Published: November 2020

Рассмотрены современные возможности медико-генетического обследования мужчин с нарушением фертильности, а также приведены показания и алгоритмы диагностики генетических причин мужского бесплодия, связанного с различными формами патозооспермии.
The current possibilities of a genetic examination of infertile men, as well as indications and diagnostic algorithms for the genetic causes of male infertility associated with various forms of pathozoospermia are presented.
The influence of Robertsonian translocations on semen parameters
Authors: Андреева М.В. , Штаут М.И. , Сорокина Т.М. , Курило Л.Ф. , Черных В.Б. 
Published: November 2020

Обследованы 19 мужчин с нарушением фертильности, носителей транслокаций rob(13;14) и rob(13;15). Показано, что нарушение репродуктивной функции обусловлено блоком сперматогенеза в профазе I мейоза, приводящего к азооспермии или олигоастенотератозооспермии и мужскому бесплодию.
We examined 19 infertile men, carriers of translocations rob (13;14) and rob (13;15). We assume that fertility problems are resulted from spermatogenesis impairment because of meiotic arrest at prophase I stages, that leads to azoospermia or oligoastenoteratozoospermia and male infertility.
Chronic systemic inflammation in pathways of metabolic syndrome associated with hyperandrogenism (review)
Authors: Игумнов И.А. , Шарифулин Э.М. , Беленькая Л.В. , Лазарева Л.М. , Аталян А.В. , Вильсон Н.И. , Сутурина Л.В. 
Published: November 2020

Данная статья представляет собой обзор публикаций по проблеме хронического системного воспаления (ХСВ) и его роли в патогенезе метаболического синдрома (МС), в частности, ассоциированного с гиперандрогенизмом (ГА). Цель: систематизация имеющихся данных о роли хронического системного воспаления в патогенезе метаболических осложнений гиперандрогенизма. Информационный поиск проводился с использованием интернет ресурсов (PubMed, EMBASE, Google Scholar, E-library), анализировались литературные источники за период 2000-2020 гг. В обзоре отражены современные представления о ХСВ и МС; описаны основные ассоциации МС и ГА. Продемонстрировано, что синдром поликистоза яичников (СПКЯ), как и МС, ассоциирован с ХСВ, инсулинорезистентностью и ожирением. При этом отмечено, что установить причинно-следственный характер данной связи не всегда представляется возможным. В заключительной части обзора обобщены сведения о наиболее значимых маркерах ХСВ, специфичных для МС и ГА.
This review addresses aspects of chronic systemic inflammation and its role in the pathogenesis of metabolic syndrome (MS) associated with hyperandrogenism (HA). The objective of this review was to systematize available data on the role of chronic systemic inflammation in the pathogenesis of metabolic complications of hyperandrogenism. Search for information was performed in the PubMed, EMBASE, Google Scholar, and E-library databases; 2000-2020 information was analyzed. The article presents the current view on chronic systemic inflammation and MS; major associations of MS and hyperandrogenism (HA) are also described. Polycystic ovary syndrome (PCOS), as well as MS, was shown to be associated with chronic systemic inflammation, insulin resistance, and obesity. However, it is not always possible to establish the causal nature of this relationship. The final part of the review summarizes information about the most significant markers of chronic systemic inflammation, which are specific for MS and HA.
Pathological processes of immunological decontamination of herpes simplex virus type 1 from the cornea
Authors: Керимов Т.З. , Соболев В.П. , Соболева М.А. , Гаврилова Н.А. , Борзенок С.А. 
Published: November 2020

В обзоре представлено описание патофизиологических механизмов герпесвирусной инфекции. Согласно данным медицинской статистики, вирусом простого герпеса 1 типа инфицировано большинство населения планеты. В развивающихся странах данный вирус является ведущей инфекционной причиной поражения роговицы. Также вирусу простого герпеса 1 типа отводится роль одного из факторов, приводящих к отторжению трансплантата роговицы. Вышеописанные патологические явления сопряжены с перестройкой клеточных систем в ответ на вирусное воздействие. Недавние открытия в данной области обнаружили значительный вклад трансмембранных и эндосомальных Toll-подобных рецепторов во врожденный противовирусный клеточный ответ. Показано, что эндосомальные Toll-подобные рецепторы 3 типа экспрессируются в кератоцитах только после их фенотипического перехода в фибробласты. Данная трансформация обычно происходит в результате механических и патогенных воздействий на роговицу. Изменение рецепторного состава клеток в ответ на герпесвирусную инвазию вызывает выработку интерферонов 1 типа - интерферона-альфа, интерферона-бета, и синтезу провоспалительных цитокинов, что приводит к вирусной деконтаминации.
This review describes pathophysiological mechanisms of herpes virus infection in cornea cells. It has been previously reported that herpes simplex virus type 1 (HSV-1) infects most of the world’s population. In developing countries, HSV-1 is the leading infectious cause of corneal damage. Also, herpes simplex virus type 1 was assigned the role of one of the factors leading to rejection of the corneal transplant. These pathological phenomena are associated with restructuring of cellular systems in response to viral exposure. Recent discoveries have revealed a significant contribution of transmembrane and endosomal Toll-like receptors to the innate antiviral cell response. It is well known that endosomal Toll-like receptors-3 are expressed in keratocytes only after their phenotypic transformation to fibroblasts. This transformation usually occurs as a result of mechanical or infectious impact on the cornea. Changes in the receptor composition of cells as a response to herpes virus invasion is the main cause of type 1 interferons (interferon-alpha and interferon-beta) production and expression of proinflammatory cytokines, which leads to viral decontamination.
Home hemodialysis : is there still room for high dialysis solution flow rate ?
Authors: Petitclerc Thierry 
Published: November 2020

Abstract
The availability in France, for the last decade, of low dialysate flow rate hemodialysis monitors, specifically adapted for daily hemodialysis (5 to 6 sessions per week), is contemporary with a real renewal of home hemodialysis. The clinical benefits of daily hemodialysis with high dialysate flow and of thrice-weekly long nocturnal hemodialysis, which are two intensive hemodialysis modalities, have been demonstrated ; however they are less well demonstrated with low dialysate flow hemodialysis. Thus, some patients may still wish to use conventional hemodialysis monitors in order to limit the number of sessions (and therefore the number of vascular punctures) to 3 per week (or every other day) or wish to benefit from a modality of intensive hemodialysis.
Management of fungal peritonitis : a Moroccan single peritoneal dialysis unit experience
Authors: Hadja Kone Moussokoro , Bouattar Tarik , Fares Ibtissam , Benbella Meryem , Ouzeddoun Naima , Bayahia Rabia , Benamar Loubna 
Published: November 2020

Introduction: Fungal peritonitis (PF) in peritoneal dialysis (PD) is a serious infection that involves the functional prognosis of the peritoneum and the patient's vital prognosis. It must benefit from a fast handling but nevertheless not very codified. Each center therefore ensures an individual care of its patients.
Materiel and method: The purpose of our study is to describe our 10-year experience through our patients who presented FP. We performed a descriptive retrospective study of FP cases documented in the PD unit.
Results: the prevalence of FP was 5,1%, which represent 9 cases. Predominant clinical signs were dialysat turbidity and abdominal pain. FP was primitive for 3 patients. The antifungal therapy used was Fluconazole, which was combined with an increased number of peritoneal exchanges. DP catheter ablation was done for 8 patients with an average delay of 5.5 days. The overall outcome was favorable and 3 patients continued PD. No death or encapsulating peritonitis was a consequence of FP.
Discussion and conclusion: FP is an infectious complication in PD. Its’ death rate is elevated; dropping-out of PD rate too is elevated. The favorable evolution of our patients that stayed in PD let us think that it may be possible to maintain more patients in PD after FP.
Editorial
Authors: Verger Christian , Dratwa Max 
Published: November 2020

Le Bulletin de la Dialyse à Domicile (BDD) existe depuis un an et 3 mois (premier numéro en juin 2018). Le nombre de téléchargements des articles, entre 150 et 300 fois, souligne son succès d’emblée auprès des infirmières comme des néphrologues. Nous remercions tous les auteurs qui ont soumis un article ainsi que nos relecteurs qui ont assuré une relecture critique en double aveugle. Tous nos relecteurs sont externes au comité éditorial, réputés pour leurs compétences, et provenant jusqu’à présent de France, Belgique, Canada, et Argentine. Le site Web de la revue a été complété, ainsi que le processus éditorial afin d’être en accord avec les recommandations internationales de bonnes pratiques pour la publication de journaux scientifiques en Libre Accès. Nous travaillons pour obtenir une indexation prochaine.
Dans ce numéro, nous inaugurons un nouveau mode de publication : les articles sont, pour la plupart, publiés en deux langues, Français et Anglais (la version anglaise est à la fin de la version française dans les fichiers pdf téléchargeables). Cela permet de recevoir des articles dans les deux langues et de rendre leur contenu accessible à la fois aux communautés francophone et anglophone. Nous espérons ainsi créer un pont entre les équipes infirmières et néphrologues de ces deux communautés, renforçant le dialogue entre cultures et augmentant la diffusion des travaux soumis
Dr Christian Verger, Prof Max Dratwa, directeurs du Bulletin de la Dialyse à Domicile.
Calciphylaxis: A successful outcome whilst on peritoneal dialysis
Authors: Gaspar Ana , Falcão Luis , Correia Sofia , Carvalho Maria João , Rodrigues Anabela , Cabrita Antonio 
Published: November 2020

Calciphylaxis is a life threatening disease for which patients with chronic kidney disease, particular those on dialysis, are at increased risk. As it is a rare condition, treatment options are limited and duration of treatment is not clear, especially when it comes to patients on renal replacement treatment with peritoneal dialysis.
We report a case of a 55 year-old woman with end stage renal disease on renal replacement treatment with peritoneal dialysis for five months that presented with severe calciphylaxis of both legs. She had started haemodialysis at the age of 31 and 3 later she received a cadaveric renal transplant that lasted for 20 years. She was treated with warfarin due to atrial fibrillation diagnosis. The treatment approach was multimodal and multidisciplinary and included treatment with sodium thiosulfate and hyperbaric oxygen, warfarin suspension and maintenance of optimized peritoneal dialysis prescription. Additionally, wound dressings were done every other day and antibiotics started whenever there were signs of infection and pain was managed with high doses of opiates and pain adjuvants. There was significant improvement and the patient kept peritoneal dialysis treatment with preserved residual renal function. This raises the question, if there is a need to transition calciphylaxis patients on peritoneal dialysis to haemodialysis, as it is possible to ensure a high efficiency dialysis program with automated peritoneal dialysis.
Initiation au Logiciel de statistiques R : réalisez vos premières visualisations avec le package ggplot2
Authors: Della Vedova Claire 
Published: November 2020

NDLR : Le RDPLF a pour but principal d’être une aide pour permettre aux équipes de dialyse à domicile d’évaluer leurs pratiques cliniques et également conduire des études à partir d’exports anonymisés des données qu’elles saisissent. A cette fin, depuis juin 2019, un article de formation à l’utilisation du logiciel Libre R est publié trimestriellement à chaque parution du Bulletin de la Dialyse à Domicile. Le but est de permettre à toutes les équipes de réaliser des statistiques de bases et visualiser rapidement leur données.
Le premier article de cette série d’initiation était consacré au téléchargment et à l’installation du logiciel R sur les ordinateurs Macintosh et PC : https://doi.org/10.25796/bdd.v2i2.20513 .
Le second article était consacré à la visualisation graphiques des données statistiques avec le package Esquisse, simple d’utilisation et nécessitant peu d’apprentissage : https://doi.org/10.25796/bdd.v2i3.21313 Ce troisième article est consacré au package ggplot2 et nécessite un effort d’apprentissage, mais il permet la réalisation de nombreux types de visualisations, avec des rendus qui peuvent être de très haute qualité, et ainsi directement utilisables dans des publications.
Comme dans les numéros précédent un fichier exemple, tiré de la base de données du RDPLF sera utlisé.
Claire Della Vedova est Ingénieure en biostatistique / data analyste, Elle utilise quotidiennement le logiciel R pour analyser des données. Elle a travaillé pendant plus de 15 ans dans les domaines de l’environnement et de la santé, et a formé de nombreux étudiants et chercheurs à l’utilisation de R. Elle anime depuis novembre 2017 le blog Statistique et Logiciel R dont le but est d’aider les débutants à mieux appréhender les méthodes statistiques classiques et à utiliser le logiciel R plus efficacement, notamment au travers de tutoriels : https://statistique-et-logiciel-r.com/.
First viral replication of Covid-19 identified in the peritoneal dialysis fluid of a symptomatic patient
Authors: Nouvier Mathilde , Chalençon Elodie , Novel-Catin Etienne , Pelletier Solenne , Hallonet Patrick , Charre Caroline , Koppe Laetitia , Fouque Denis 
Published: November 2020

RETRACTED : the authors retracted see : https://bdd.rdplf.org/index.php/bdd/article/view/54713
The COVID-19 pandemic is characterized by a disease with mainly respiratory tropism and varying severity.
Viral excretion of COVID-19 has been described in both urine and stool with the risk of contamination by stool. No viral replication in the peritoneal dialysis fluid has been reported to date.
We report an observation demonstrating the presence of the virus in the peritoneal dialysis drainage fluid of a COVID-19 patient. This underlines the importance in COVID-19 patients of considering dialysis fluid as a possible source of contamination.
Covid-19 epidemic in the dialysis units of the french speaking part of Belgium : special insight into patients on home dialysis
Authors: Collart Fredéric , Des Grottes Jean-Marin , Baudoux Thomas , Cuvelier Charles , Debelle Frederic , Goffin Eric , Masset Catherine , Mat Olivier , Cornet Georges 
Published: November 2020

In the French-speaking part of Belgium, between march and end of may 2020, 284 patients have suffered a Covid-19 infection, 7,9% of the prevalent dialysis population. Some of them have been diagnosed through rt-PCT as they were symptomatic, others, asymptomatic, being diagnosed by swab viral culture. Fifty two patients died (18% of the positive patients). The vast majority of them were patients on hemodialysis, only ten cases have been observed in patients on home dialysis techniques. Primary renal disease were diabetes or renal hypertensive disease in more than 50% of the patients and the most important comorbidities were cardiac ischemic or congestive disease, autonomy problems, cancer and smoking habits.
Transition between peritoneal dialysis and home hemodialysis in Belgium and France in the RDPLF
Authors: Verger Christian , Fabre Emmanuel 
Published: November 2020

A renewed interest in home hemodialysis has emerged in recent years, favored by the availability of new dialysis machines and encouraging publication about daily hemodialysis. Since 2013, the RDPLF has become a home dialysis registry that records the data of patients treated with peritoneal dialysis and those treated with home hemodialysis, all techniques combined. Nine Belgian centers and fifty seven French centers communicate information about their patients treated by hemodialysis at home. In the RDPLF centers, 56% of Belgian home hemodialysis patients are treated with daily hemodialysis, in France 83% of home patients are on daily dialysis. This French difference however is not representative of the whole country but can be explained through recruitment of new centers already involved in peritoneal dialysis and convinced by the interest of continuaous daily treatment. In both countries, 13% of home hemodialysis patients have been previously treated with peritoneal dialysis with an interim period of in-center hemodialysis or transplantation. The median duration of in center hemodialysis is 10 months with extremes ranging from 2 months to 25 years. PD patients treated secondarily in home hemodialysis are mainly young, non-diabetic and independent patients. Early information in patients who have a risk of peritoneal dialysis failure, and the provision of materials allowing both techniques would reduce or abolish a transient transfer to in center hemodialysis and would ensure home care in patients who prefer.
Completion of Partial Reaction Equations
Authors: Vaucher Alain C. , Schwaller Philippe , Laino Teodoro 
Published: November 2020

We present a deep-learning model for inferring missing molecules in reaction equations. Such an algorithm features multiple interesting behaviors. First, it can infer the necessary reagents and solvents in chemical transformations specified only in terms of main compounds, as often resulting from retrosynthetic analyses. The completion with necessary reagents ensures that reaction equations are compatible with deep-learning models relying on a complete reaction specification. Second, it can cure existing datasets by detecting missing compounds, such as reagents that are essential for given classes of reactions. Finally, this model is a generalization of models for forward reaction prediction and retrosynthetic analysis, as both can be formulated in terms of incomplete reaction equations. We illustrate that a single trained model, based on the transformer architecture and acting on reaction SMILES strings, can address all three points.Workshop paper at the Machine Learning for Molecules Workshop at NeurIPS 2020.
Chronotype distribution in the Chinese population
Authors: Liu Zhiwei , Dong Yingying , Xu Ying , Zhou Fei 
Published: November 2020

Purpose: Individual chronotypes are reported to be closely associated with mood, health status, and even disease progression. However, no reports of chronotype distribution in the Chinese population have been made available to date. Methods: We performed a chronotype survey using the classic Morningness–Eveningness Questionnaire both online and offline. The webpage-based online survey was distributed via a social network application on mobile phones. The offline survey was distributed to local primary and middle schools. A total of 9476 questionnaires were collected, of which 8395 were valid. The mean age of the participants was 30.38 ± 11.47 years, and 37.38% were male. Results: Overall, the Chinese chronotypes showed a near-normal distribution with a slight shift toward eveningness. When analyzed in different age groups, the overall Chinese population was shown to be “latest” in their early twenties. In the young population, two significant points of change in chronotype were identified at the ages of 10 and 16 years. The chronotype composition remained relatively stable during early adulthood (from 17 to 28 years of age). Conclusion: This study generated the first overview of chronotype distribution in the Chinese population and will serve as essential background data for future studies.
RAHASIA DAGANG: INFORMASI DAN HUKUM POSITIF PADA JASA TELEKOMUNIKASI INDONESIA
Authors: Safiranita Tasya , Yasmine Mayesha Andreana , Putri Sherly Ayuna , Ramli Ahmad M 
Published: November 2020

Rahasia Dagang merupakan suatu produk dari Hukum Kekayaan Intelektual (KI), memiliki kekhususan yang cukup tinggi berkaitan dengan informasi secara ekonomi dan bisnis, salah satu kaitannya yaitu dengan Perlindungan Data berlandaskan Hak Asasi Manusia yang menjadi hak secara universal , dalam hal ini ada kaitan antara Perlindungan Data pada Hukum Telekomunikasi. Dalam ketentuan umum Pasal 1 Undang-Undang Rahasia Dagang (Undang-Undang Nomor 30 Tahun 2000), menyebutkan bahwa Rahasia Dagang merupakan informasi yang tidak diketahui oleh umum dibidang teknologi dan/ atau bisnis, mempunyai nilai ekonomi karena berguna dalam kegiatan usaha, dan dijaga kerahasiaannya oleh pemilik Rahasia Dagang. Latar Belakang Penelitian ini terdapat dua permasalahan hukum, yaitu yang Pertama : Bagaimanakah Perlindungan Hukum Positif pada Jasa Telekomunikasi di Indonesia dan Kedua : Sejauhmana Perlindungan Hukum atas Informasi Data di Indonesia.

Metode Penelitian yang dipakai yaitu kajian secara Yuridis Normatif, dimana metode ini menerangkan kajian berupa hukum positif di Indonesia. Dalam Penelitian ini juga berdasarkan kajian pada suatu perbandingan hukum yang berlandaskan pada pendekatan secara Yuridis Komparatif yaitu dengan melakukan perbandingan hukum baik secara nasional maupun internasional dengan ketentuan di negara-negara berkembang lainnya.

Hasil Penelitian ini menunjukkan bahwa Informasi Data yang berkembang secara umum melalui Jasa Telekomunikasi merupakan suatu hal yang perlu dilindungi secara hukum, terkait dengan Pengertian Rahasia Dagang sebagai suatu kajian atas Informasi dan juga ada pada ketentuan Undang-Undang Dasar 1945 tentang Perlindungan Data di Indonesia, yang seyogyanya bahwa suatu Informasi milik seseorang harus dilindungi secara utuh berdasarkan kekuatan Hukum Positif di Indonesia.

Kata Kunci : Rahasia Dagang, Informasi, Perlindungan Data dan Telekomunikasi.