bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on entropy generation strategy and its application in carbon trading market
Authors: Zhenjian Miao , Boamah Kofi Baah , Long Xingle 
Published: February 2020

AbstractThe study seeks to provide a deeper insight and strategies into the carbon trading market, the internal mechanism, and the linkage mechanism for emission reduction in the carbon trading market right from its inception. The study differs from most prior research on carbon trading, as this current paper incorporates the carbon market with the dissipative structure theory. Based on the dissipative structure theory, this study adapts the entropy generation principle as the base for the carbon trading market. The study captures the following key dimensions: the change of carbon market value, the entropy generation principle of carbon quota trading process, and the replacement process involved in production factors in carbon trading. The study revealed that the entropy generation of the carbon trading market is mainly caused by the cost gradient formed as a result of the cost difference of emission reduction and the increase of production factor input required by economic development. Moreover, the study revealed clearly the dynamics of the entropy index and the carbon market emission reduction efficiency. Thus, the lower the entropy value of the carbon market, the higher the emission reduction efficiency.
Fangjihuangqi Decoction inhibits MDA‐MB‐231 cell invasion in vitro and decreases tumor growth and metastasis in triple‐negative breast cancer xenografts tumor zebrafish model
Authors: Guo Yubo , Fan Yingyi , Pei Xiaohua 
Published: February 2020

AbstractTriple‐negative breast cancer (TNBC) is a basal‐like cancer which is considered to be more intrusive, have a poorer prognosis and chemoresistance. TNBC is characterized by the presence of epithelial to mesenchymal transition (EMT) that plays a major role in the progression of the cancer. In the present study, we first use a classic prescription of Chinese medicine Fangjihuangqi Decoction to treat TGFβ1‐induced MDA‐MB‐231 cells in vitro. Our data showed that TGFβ1‐induced MDA‐MB‐231 cell morphology change, promoted MDA‐MB 231 invasion, increased Vimentin expression, and decreased E‐cadherin expression. Further, Fangjihuangqi Decoction‐medicated serum (FHS) treated both MDA‐MB 231 cells and TGFβ1‐induced MDA‐MB‐231 cells. Results showed that Fangjihuangqi Decoction could inhibit cell proliferation, reduce cell invasion, increase E‐cadherin expression, and decrease EMT markers. Secondly, we established a xenograft tumor zebrafish model to assess Fangjihuangqi Decoction inhibition of cancer cell proliferation and invasion. Our results indicated that Fangjihuangqi Decoction could inhibit tumor growth, restrain the sprouts number of tumor neovascularization, and reduce the length of tumor neoplastic lymphatics by increasing E‐cadherin expression and decreasing EMT markers in TNBC xenograft tumor zebrafish model. Overall, our studies provide evidences that Fangjihuangqi Decoction could inhibit TNBC, reverse EMT, and contribute to antimetastasis by increasing E‐cadherin expression and decreasing EMT markers, which provide an experimental basis for clinical application of Fangjihuangqi Decoction on TNBC treatment.
Magnesium Borate Fiber Coating Separators with High Lithium‐Ion Transference Number for Lithium‐Ion Batteries
Authors: Wang Xin , Peng Longqing , Hua Haiming , Liu Yizheng , Zhang Peng , Zhao Jinbao 
Published: February 2020

AbstractIn this work, magnesium borate fiber (MBO) is used as a functional ceramic to coat onto a polypropylene (PP) separator (MBO@PP). This MBO coating layer increases the lithium‐ion transference number (tLi+) from 0.24 to 0.57 in the LiPF6‐based electrolyte due to the MBO acting as Lewis acid sites interacts with Lewis base
. The increase in the tLi+ reduces the concentration polarization and promotes the migration of lithium ions. Besides, the prepared MBO@PP separator has better wettability with liquid electrolyte, the electrolyte uptake as well as thermal stability. The LiFePO4 half‐coin with MBO@PP separator not only had better cycle stability, but also had a higher capacity retention rate at high current.
Comparison of the long‐term impact and clinical outcomes of fewer doses and standard doses of human papillomavirus vaccine in the United States: A database study
Authors: Rodriguez Ana M. , Zeybek Burak , Vaughn Micah , Westra Jordan , Kaul Sapna , Montealegre Jane R. , Lin Yu‐Li , Kuo Yong‐Fang 
Published: February 2020

BackgroundHuman papillomavirus (HPV)–related disease remains a significant source of morbidity and mortality, and this underscores the need to increase HPV vaccination to reduce the burden of the disease. The objective of this study was to examine the association between the number of HPV vaccine doses and the risk of histologically confirmed preinvasive cervical disease and high‐grade cytology.MethodsThis retrospective matched cohort study used administrative data from Optum's Clinformatics DataMart Database to identify females aged 9 to 26 years who received 1 or more quadrivalent HPV vaccine doses between January 2006 and June 2015. Cases and controls were matched on region, age, sexually transmitted disease history, and pregnancy. All had a Papanicolaou test ≥1 year after the date of the matched case's final dose. Cox proportional hazards models were used to examine the association between the number of HPV vaccine doses and the incidence of preinvasive cervical disease and high‐grade cytology. The Kaplan‐Meier method was used to estimate the cumulative incidence rate at the 5‐year follow‐up.ResultsThe study included 133,082 females (66,541 vaccinated and 66,541 unvaccinated) stratified by the number of HPV vaccine doses and the vaccine initiation age. Among those aged 15 to 19 years, the hazard ratio (HR) for high‐grade cytology for the 3‐dose group was 0.84 (95% confidence interval [CI], 0.73‐0.97), whereas the HRs for histologically confirmed preinvasive cervical disease for 1, 2, and 3 doses were 0.64 (95% CI, 0.47‐0.88), 0.72 (95% CI, 0.54‐0.95), and 0.66 (95% CI, 0.55‐0.80), respectively.ConclusionsThe receipt of 1, 2, or 3 doses of an HPV vaccine by females aged 15 to 19 years was associated with a lower incidence of preinvasive cervical disease in comparison with unvaccinated females, and this supports the use of any HPV vaccination in reducing the burden of the disease.
Smad anchor for receptor activation nuclear localization during development identifies Layers V and VI of the neocortex
Authors: Mestres Ivan , Einsiedel Maximilian , Möller June , Cardoso de Toledo Beatriz 
Published: February 2020

AbstractSmad anchor for receptor activation (SARA, zfyve9) has been classically observed in early endosomes of different cells types where it regulates vesicular transport of proteins and membrane components. Very few other members of the zinc finger FYVE domain‐containing family (zfyve) have different functions other than controlling membrane trafficking. By analyzing SARA localization throughout mouse embryonic brain development, we detected that besides the endosomal localization it also targets neuronal nuclei, specifically of the cortical layers V/VI. These findings were confirmed in human brain organoids. When evaluating neuronal cell lines, we found that SARA accumulates in nuclei of PC‐12 cells, but not Neuro‐2a, highlighting its specificity. SARA functions as a specific marker of the deep cortical layers until the first postnatal week. This temporal regulation corresponds with the final phases of neuron differentiation, such as soma ventral translocation and axonal targeting. In sum, here we report that SARA localization during brain development is temporarily regulated, and layer specific. This defined pattern helps in the identification of early born cortical neurons. We further show that other zfyve family members (FYCO1, WDFY3, Hrs) also distribute to nuclei of different cells in the brain cortex, which raises the possibility that this might be an extended feature within the protein family.
The foundations of visual neuroscience in Australia
Authors: Vaney David I. 
Published: February 2020

AbstractThe passing of Jack Pettigrew (University of Queensland) and Bogdan Dreher (University of Sydney) within 2 weeks of each other in May 2019 provided the catalyst for documenting the roles that they and their colleagues from the Peter Bishop School played in establishing vision research as a major strength in Australian neuroscience in the second half of the 20th century.
Ultra‐pH‐Sensitive Small Molecule Probe Showing a Ratiometric Fluorescence Color Change
Authors: Cui Junjie , Kim Gayoung , Kim Sehoon , Kwon Ji Eon , Park Soo Young 
Published: February 2020

AbstractWe synthesized an amphiphilic small molecule 1 by attaching oligo(ethylene glycol) (OEG) and N,N‐diethylamine (DEA) units to a fluorescent dicyanodistyrylbenzene (DCS) core. The molecule is fully soluble in aqueous solution at low pH (pH<4.3) by protonation of the DEA groups; but, above pH 4.3, it self‐assembles to form nanoparticles due to increased hydrophobicity upon deprotonation, leading to a ratiometric fluorescence color change from green emission in the monomeric form (λem,max=538 nm) to red emission in the aggregated form (λem,max=646 nm). It should be noted that the ratio of emission intensities at 538 nm and 646 nm (R=I538/I646) changes drastically about 42‐fold within a very narrow pH range of 4.3–4.6.
Reversible Hybrid Aqueous Li−CO2 Batteries with High Energy Density and Formic Acid Production
Authors: Yang Rui , Peng Zhen , Xie Jiafang , Huang Yiyin , Borse Rahul Anil , Wang Xueyuan , Wu Maoxiang , Wang Yaobing 
Published: February 2020

AbstractMetal−CO2 batteries, an attractive technology for both energy storage and CO2 utilization, are typically classified into organic Li(Na)−CO2 batteries with a high energy density/output voltage and aqueous Zn−CO2 batteries with flexible chemical production. However, achieving both high‐efficiency energy storage and flexible chemical production is still challenging. In this study, a reversible hybrid aqueous Li−CO2 battery is developed, integrating Li with an aqueous phase, which exhibits not only a high operating voltage and energy density but also highly selective formic acid production. Based on a Li plate as the anode, NaCl solution as the aqueous electrolyte, solid electrolyte Li1.5Al0.5Ge1.5P3O12 (LAGP) as a separator and Li+ transporter, and a bifunctional Pd‐based electrocatalyst as the cathode, the resulting battery shows a high discharge voltage of up to 2.6 V, an outstanding energy conversion efficiency of above 80 %, and remarkable selectivity of CO2‐to‐HCOOH conversion of up to 97 %. The related reaction mechanism is proposed as CO2+2 Li+2 H+⇌HCOOH+2 Li+.
Sensitive period for the acceptance of unpalatable flavors in the presence of a preexposed odor in infant rats
Authors: Ifran María C. , Suárez Andrea B. , Pautassi Ricardo M. , Kamenetzky Giselle V. 
Published: February 2020

AbstractIt has been shown that exposure to familiar odors facilitate the acceptance of bitter flavors in preweanling rats, yet it unknown how long this phenomenon persists. This study assessed, in 9‐ or 15‐day‐old Wistar rats, the influence of a familiar scent (i.e., lemon) on the intake of and behavioral responsiveness (i.e., mouthing, paw lick, chin rub, head shake, among other taste reactivity responses) elicited by a 0.1% quinine solution. The results showed heightened quinine intake in 9‐day‐old rats that had been preexposed to the odor, when compared to non‐preexposed controls. This result was replicated in Experiment 2, which also documented no alterations in behavioral responsiveness toward quinine in the 9‐day‐old rats, as a function of the pre‐exposure. More importantly, 15‐day‐old rats exhibited no alterations in intake or behavioral responsiveness toward quinine as a function of odor pre‐exposure. These results suggest that the effects of odor pre‐exposure upon acceptance of bitter tastes may occur within a sensitive period for the acceptance of bitter food.
Experimental evaluation of the fatigue life of hydraulic gate cast iron rollers
Authors: Lashari Abdul Nabi , Polyzois Ioannis , Polyzois Dimos 
Published: February 2020

AbstractFixed‐wheel gates with wheels mounted on both sides that roll on roller path plates are used in both emergency intake gates and spillway gates in hydrogenerating stations. Environmental corrosion along with high wheel loads cause differences in the profile of the roller path surface. Combined with the relatively high torsional stiffness of the gate end girders, a condition of wheel load redistribution occurs where some wheels are relieved of load while others are loaded beyond their maximum design values. Failure of one wheel could jeopardize the overall operation of the gate. Furthermore, frequent operation of these gates result in changes in the stress profile in both wheels and roller paths that, potentially, could lead to failure. Currently, design guidelines for gate wheels and roller paths do not consider the fatigue life of these elements. Research‐based evidence is provided to support changes to these guidelines.
Collaborative energy efficient zone‐based routing protocol for multihop Internet of Things
Authors: Iqbal Saleem , Qureshi Kashif Naseer , Kanwal Nabeela , Jeon Gwanggil 
Published: February 2020

ABSTRACTIn Internet of Things (IoT) the nodes collaborate over a network in multihop manner and relay data toward IoT gateway that is ultimately connected to an IP network. The conventional multihop routing protocols assume that all nodes behave truthfully when they receive packets for downstream network but in reality, the IoT relaying nodes avoid message forwarding. The main reason of selfish behavior of nodes is the limited battery power. Many such nodes have limited battery constraint so these nodes may become selfish to save their energy. These nodes need to be encouraged to cooperate in order to increase network life time instead of just trying to increase node's own benefits. This paper discusses energy aware zone‐based routing technique that employs game theory to enhance nodes' cooperation and energy efficiency. The nodes follow a path with highest average energy for communication and provide collective support, hence the network life time is increases. For comparative analysis, simulation is performed for the proposed technique along with the existing techniques. The results show betterment in throughput, packet delivery ratio, and network life time.
Absence of microglia or presence of peripherally‐derived macrophages does not affect tau pathology in young or old hTau mice
Authors: Zhu Keying , Pieber Melanie , Han Jinming , Blomgren Klas , Zhang Xing‐Mei , Harris Robert A. , Lund Harald 
Published: February 2020

AbstractMicroglia are implicated in the pathophysiology of several neurodegenerative disorders, including Alzheimer's disease. While the role of microglia and peripheral macrophages in regulating amyloid beta pathology has been well characterized, the impact of these distinct cell subsets on tau pathology remains poorly understood. We and others have recently demonstrated that monocytes can engraft the brain and give rise to long‐lived parenchymal macrophages, even under nonpathological conditions. We undertook the current study to investigate the regulation of tau pathology by microglia and peripheral macrophages using hTau transgenic mice, which do not exhibit microglial activation/pathology or macrophage engraftment. To assess the direct impact of microglia on tau pathology we developed a protocol for long‐term microglial depletion in Cx3cr1CreERR26DTA mice and crossed them with hTau mice. We then depleted microglia up to 3 months in both young and old mice, but no net change in forebrain soluble oligomeric tau or total or phosphorylated levels of aggregated tau was recorded. To investigate the consequence of peripherally‐derived parenchymal macrophages on tau aggregation we partially repopulated the hTau microglial pool with peripheral macrophages, but this also did not affect levels of tau oligomers or insoluble aggregates. Our study questions the direct involvement of microglia or peripheral macrophages in the development of tau pathology in the hTau model.
Health‐related quality of life among tonsillar carcinoma patients in Sweden in relation to treatment and comparison with quality of life among the population
Authors: Adnan Ali , Högmo Anders , Sjödin Helena , Gebre‐Medhin Maria , Laurell Göran , Reizenstein Johan , Farnebo Lovisa , Norberg Lena S. , Notstam Isak , Holmberg Erik , Cange Hedda H. , Hammerlid Eva ,   the Swedish Head and Neck Cancer Register (SweHNCR)
Published: February 2020

AbstractBackgroundThe health‐related quality of life (HRQOL) of tonsillar carcinoma survivors was explored to investigate any HRQOL differences associated with tumor stage and treatment. The survivors' HRQOL was also compared to reference scores from the population.MethodsIn this exploratory cross‐sectional study patients were invited 15 months after their diagnosis and asked to answer two quality of life questionnaires (EORTC QLQ‐ C30, EORTC QLQ‐ HN35), 405 participated.ResultsHRQOL was associated with gender, with males scoring better than females on a few scales. Patients' HRQOL was more associated with treatment than tumor stage. Patients' HRQOL was worse than that in an age‐ and sex‐matched reference group from the normal population, the largest differences were found for problems with dry mouth followed by problems with sticky saliva, senses, swallowing and appetite loss.ConclusionsThe tonsillar carcinoma patients had a worse HRQOL compared to the general population one year after treatment.
Rectifying an unconstitutional dispensation? A consideration of proposed reforms relating to no income no asset debtors in South Africa
Authors: Coetzee Hermie , Roestoff Melanie 
Published: February 2020

AbstractThe South African natural person debt relief system remains heavily procreditor and consequently excludes many deserving debtors from any form of relief. This is despite the fact that such marginalisation amounts to unjustifiable, unfair discrimination on the basis of debtors' financial status. The main aim of this article is to establish whether proposed reforms, and specifically the debt intervention procedure, will rectify the current unconstitutional dispensation and particularly the unreasonable unfair discrimination against “no income no asset” (NINA) debtors, who undoubtedly constitutes the largest part of relegated debtors. The article may benefit developing countries seeking to introduce debt relief measures curtailed to the needs of their ever‐escalating NINA debtors.
Transmembrane protein 106C promotes the development of hepatocellular carcinoma
Authors: Luo Xi , Han Gang , Lu Renfei , Guan Shaopei , Wang Yifan , Ju Linling , Chen Lin , Shao Jianguo , Bian Zhaolian 
Published: February 2020

AbstractSeveral protein‐coding genes have been identified to play essential roles in cancer biology, and they are dysregulated in many tumors. Transmembrane protein 106C (TMEM106C) is differentially expressed in several human and porcine diseases; however, the expression and biological functions of TMEM106C in hepatocellular carcinoma (HCC) are not clear. In our study, we obtained paired tissue samples from patients undergoing resection for HCC and public databases, which were analyzed for TMEM106C expression using quantitative real‐time polymerase chain reaction (qRT‐PCR). We further conducted in vitro and in vivo experiments in HCC cell lines and nude mice, respectively, in which TMEM106C was overexpressed or knocked down. Cell‐Counting Kit‐8 and colony formation experiments were used to determine the influence of TMEM106C on cell proliferation, flow cytometric assays were used to detect the influence on cell cycle distribution and apoptosis, and transwell assays were used for detecting changes in cell migration and invasion. TMEM106C levels were significantly elevated in HCC tissues and cell lines from public databases and our collected specimens from patients. Moreover, higher TMEM106C expression levels predicted a poor prognosis in HCC patients in survival analysis. Overexpression of TMEM106C in HCC cells accelerated cell growth, migration, and invasion, but it inhibited cell apoptosis by targeting forkhead box O‐1 (FOXO1) and FOXO3. Conversely, TMEM106C knockdown impeded cell proliferation and metastasis, whereas it enhanced the rate of apoptosis. More important, knockdown of the expression of TMEM106C in HCC cells inhibited the growth of xenograft tumors in vivo. Collectively, these results suggest that TMEM106C acts as an oncogene and can serve as a potential therapeutic target for HCC in the future.
Oncogene PLCE1 may be a diagnostic biomarker and prognostic biomarker by influencing cell cycle, proliferation, migration, and invasion ability in hepatocellular carcinoma cell lines
Authors: Wang Xiang‐Kun , Liao Xi‐Wen , Yang Cheng‐Kun , Liu Zheng‐Qian , Han Quan‐Fa , Zhou Xin , Zhang Lin‐Bo , Deng Teng , Gong Yi‐Zhen , Huang Jian‐Lu , Huang Rui , Han Chuang‐Ye , Yu Ting‐Dong , Su Hao , Ye Xin‐Ping , Peng Tao , Zhu Guang‐Zhi 
Published: February 2020

AbstractHepatocellular carcinoma (HCC) is a lethal malignancy worldwide. HCC has traits of late diagnosis and high recurrence. This study explored potential diagnosis and prognosis significance of phospholipase C epsilon 1 (PLCE1) in HCC. The messenger RNA (mRNA) levels and diagnostic value of PLCE1 were determined by real‐time polymerase chain reaction and online databases GEPIA, oncomine, and GSE14520 data set. Survival analysis used the Kaplan–Meier Plotter website. Cell cycle, proliferation, migration, and invasion assays were performed with downregulated PLCE1 expression in HCC‐M and HepG2 cell lines. PLCE1 was differentially expressed and highly expressed in tumors and had low expression in nontumor tissues (all p < .05). The diagnostic value of PLCE1 was validated with the datasets (all p < .01, all areas under curves > 0.7). PLCE1 mRNA expression was associated with the overall and relapse‐free survival (both p < .05). Functional experiments indicated that downregulation of PLCE1 expression led to increased G1 stage in cell cycle and decreased cell proliferation, migration, and invasion compared with a negative control group (all p ≤ .05). The oncogene PLCE1 was differentially expressed in HCC and non‐HCC tissues. It is a candidate for diagnosis and serves as prognosis biomarker. PLCE1 influenced survival by affecting the cell cycle, proliferation, migration, and invasion ability.
Plasma antibacterial activities in ornate (Terrapene ornata) and eastern box turtles (Terrapene carolina)
Authors: Adamovicz Laura , Baker Sarah J. , Merchant Mark , Allender Matthew C. 
Published: February 2020

AbstractChelonians are one of the most imperiled vertebrate taxa and many species are increasingly threatened by disease, however, the immune response in this group is understudied. We quantified the innate immune response of eastern (Terrapene carolina; EBT) and ornate (Terrapene ornate; OBT) box turtles using plasma antibacterial activity assays. Plasma from both species abolished or significantly reduced the growth of all eight bacterial species evaluated, including Salmonella typhimurium, Escherichia coli, Enterobacter cloacae, Citrobacter freundi, Bacillus subtilis, Staphylococcus epidermidis, and Staphylococcus aureus. Bactericidal capacity was greater in OBT compared to EBT, and OBT plasma retained high antibacterial activities at a broader temperature range (20–40°C) compared to EBT (30–40°C). Plasma antibacterial activity was abolished following treatment with heat, protease, and ethylenediaminetetraacetic acid, indicating that complement is likely responsible for the observed effects. Further characterization of the box turtle immune response may provide insight into the importance of infectious diseases for species conservation, enabling the development of more efficient and effective population management strategies.