bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated GMP compliant production of [18F]AlF-NOTA-octreotide
Authors: Tshibangu Térence , Cawthorne Christopher , Serdons Kim , Pauwels Elin , Gsell Willy , Bormans Guy , Deroose Christophe M. , Cleeren Frederik 
Published: January 2020

AbstractBackgroundGallium-68 labeled synthetic somatostatin analogs for PET/CT imaging are the current gold standard for somatostatin receptor imaging in neuroendocrine tumor patients. Despite good imaging properties, their use in clinical practice is hampered by the low production levels of68Ga eluted from a68Ge/68Ga generator. In contrast,18F-tracers can be produced in large quantities allowing centralized production and distribution to distant PET centers. [18F]AlF-NOTA-octreotide is a promising tracer that combines a straightforward Al18F-based production procedure with excellent in vivo pharmacokinetics and specific tumor uptake, demonstrated in SSTR2 positive tumor mice. However, advancing towards clinical studies with [18F]AlF-NOTA-octreotide requires the development of an efficient automated GMP production process and additional preclinical studies are necessary to further evaluate the in vivo properties of [18F]AlF-NOTA-octreotide. In this study, we present the automated GMP production of [18F]AlF-NOTA-octreotide on the Trasis AllinOne® radio-synthesizer platform and quality control of the drug product in accordance with GMP. Further, radiometabolite studies were performed and the pharmacokinetics and biodistribution of [18F]AlF-NOTA-octreotide were assessed in healthy rats using μPET/MR.ResultsThe production process of [18F]AlF-NOTA-octreotide has been validated by three validation production runs and the tracer was obtained with a final batch activity of 10.8 ± 1.3 GBq at end of synthesis with a radiochemical yield of 26.1 ± 3.6% (dc), high radiochemical purity and stability (96.3 ± 0.2% up to 6 h post synthesis) and an apparent molar activity of 160.5 ± 75.3 GBq/μmol. The total synthesis time was 40 ± 3 min. Further, the quality control was successfully implemented using validated analytical procedures. Finally, [18F]AlF-NOTA-octreotide showed high in vivo stability and favorable pharmacokinetics with high and specific accumulation in SSTR2-expressing organs in rats.ConclusionThis robust and automated production process provides high batch activity of [18F]AlF-NOTA-octreotide allowing centralized production and shipment of the compound to remote PET centers. Further, the production process and quality control developed for [18F]AlF-NOTA-octreotide is easily implementable in a clinical setting and the tracer is a potential clinical alternative for somatostatin directed68Ga labeled peptides obviating the need for a68Ge/68Ga-generator. Finally, the favorable in vivo properties of [18F]AlF-NOTA-octreotide in rats, with high and specific accumulation in SSTR2 expressing organs, supports clinical translation.
Health Insurance Literacy and Financial Hardship in Women Living With Metastatic Breast Cancer
Authors: Williams Courtney P. , Pisu Maria , Azuero Andres , Kenzik Kelly M. , Nipp Ryan D. , Aswani Monica S. , Mennemeyer Stephen T. , Pierce Jennifer Y. , Rocque Gabrielle B. 
Published: January 2020

PURPOSE: In patients with metastatic breast cancer (MBC), low health insurance literacy may be associated with adverse material conditions, psychological response, and coping behaviors because of financial hardship (FH). This study explored the relationship between health insurance literacy and FH in women with MBC. METHODS: This cross-sectional study used data collected from 84 women receiving MBC treatment at 2 southeastern cancer centers. Low health insurance literacy was defined as not knowing premium or deductible costs. FH was defined by lifestyle changes as a result of medical expenses, financial toxicity, and medical care modifications attributable to cost. Mean differences were calculated using Cramer’s V. Associations between health insurance literacy and FH were estimated with adjusted linear models. RESULTS: Half of the surveyed patients had low health insurance literacy, 26% were underinsured, 45% had private insurance, 39% had Medicare, and 15% had Medicaid. Patients with low health insurance literacy more often reported borrowing money (19% v 4%; V = 0.35); an inability to pay for basic necessities like food, heat, or rent (10% v 4%; V = 0.18); and skipping a procedure (8% v 1%; V = 0.21), medical test (7% v 0%; V = 0.30), or treatment (4% v 0%; V = 0.20) compared with patients with high health insurance literacy. Median Comprehensive Score for Financial Toxicity was 23 (interquartile range, 17-29). In adjusted models, health insurance literacy was not associated with financial toxicity. CONCLUSION: Low health insurance literacy was common in women receiving MBC treatment. Additional research to increase health insurance literacy could lessen undesirable material FH and unnecessary behavioral FH associated with cancer-related care.
Distribution of Tri-Ponderal Mass Index and its Relation to Body Mass Index in Children and Adolescents Aged 10 to 20 Years
Authors: Park Hong Kyu , Shim Young Suk 
Published: January 2020

Abstract

Context
Body mass index percentiles are widely used to determine overweight and obesity status in children and adolescents. Their limitations in clinical settings can be addressed.

Objective
Reference ranges for the tri-ponderal mass index percentiles of Korean children and adolescents are presented for a comparison of their clinical variables with those of body mass index.

Design
Cross-sectional study.

Setting
Korea National Health and Nutrition Examination Survey, 2007–2016.

Patients
Korean children and adolescents aged 10 to 20 years.

Main Outcome Measures
The age- and sex-specific least mean square parameters (skewness, median, and coefficient of variation) for the tri-ponderal mass index of 9749 subjects aged 10 to 20 years.

Results
The factors associated with metabolic syndrome, except diastolic blood pressure, were more likely to be worse in the subjects with tri-ponderal mass index values indicative of overweight status than in those with normal tri-ponderal mass index values. Body mass index tends to underestimate obesity-related comorbidities more than tri-ponderal mass index does.

Conclusion
The tri-ponderal mass index standard deviation score may be advantageous when defining overweight and obesity in children and adolescents.
Organizational Culture and Educational Innovations in Turkish Higher Education: Perceptions and Reactions of Students
Authors: Caliskan Aysun , Zhu Chang 
Published: January 2020

With the enormous scientific and technological developments, higher education institutions are facing rapid structural, social, technological changes. Because they are considered as an important center of talent development and knowledge production and sharing for countries. To fulfill their educational, social and economic needs, higher education institutions need to respond to changing education needs, to adopt the more flexible modes of organizational culture. Organizational culture is a promotive environment which influences values, assumptions and beliefs. In an innovative culture, people can easily develop new ideas and exhibit collaboration. Therefore, this paper examines the relationship between the organizational culture features and the perceptions and student reported implementation with regard to student-centered learning, collaborative learning and use of innovative educational technologies in Turkish higher education. Four universities were involved, and 894 students responded to a questionnaire comprising three groups of questions. The three groups of questions capture (i) demographic characteristics, (ii) student perceptions of organizational culture, (iii) students’ perceptions of and responses to educational innovations comprising the following scales in a survey study. The results show that features of organizational culture affect students’ perceived need for innovation, their views about innovative approaches to instruction, responsiveness to instructional innovations and the perceived implementation level of educational innovations. In addition, differences among the institutions were examined and discussed. The study concludes that hierarchical structure, lack of open communication and autonomy, workload, lack of financial resources and support are main barriers for educational innovations in Turkish universities. It also implies to understand the link between organizational culture and educational innovations in Turkish higher education context.
Experiencing the Detection of Radicalized Criminals on Facebook Social Network and Data-related Issues
Authors: Tundis Andrea , Böck Leon , Stanilescu Victoria , Mühlhäuser Max 
Published: January 2020

Online social networks (OSNs) represent powerful digital tools to communicate and quickly disseminate information in a non-official way. As they are freely accessible and easy to use, criminals abuse of them for achieving their purposes, for example, by spreading propaganda and radicalising people. Unfortunately, due to their vast usage, it is not always trivial to identify criminals using them unlawfully. Machine learning techniques have shown benefits in problem solving belonging to different application domains, when, due to the huge dimension in terms of data and variables to consider, it is not feasible their manual assessment. However, since the OSNs domain is relatively young, a variety of issues related to data availability makes it difficult to apply and immediately benefit from such techniques, in supporting the detection of criminals on OSNs. In this perspective, this paper wants to share the experience conducted in using a public dataset containing information related to criminals in order to both (i) extract specific features and to build a model for the detection of terrorists on Facebook social network, and (ii) to highlight the current limits. The research methodology as well as the gathered results are fully presented and then the data-related issues, emerged from this experience, are discussed.
.
Searching for an OxChain: Co-designing blockchain applications for charitable giving
Authors: Elsden Chris , Symons Kate , Speed Chris , Vines John , Spaa Anne 
Published: January 2020

Abstract
The OxChain project is investigating the design of blockchain applications in partnership with a large and traditionally trusted institution, Oxfam. We outline some of the potential opportunities that distributed ledger technologies could offer the charity and development sector as a whole, but focus on the challenges of undertaking co-design work in the context of large institutions. We suggest the need to leverage existing trusted relationships and understand the unique value that such institutions offer.
Cloud Euphoria✿: A post-analysis on the networked effects of emotions
Authors: Plessas Angelo 
Published: January 2020

Abstract
Nowadays we live in a maze of perplexity and contradiction, treating feelings as data, like augmenting them, compress them, duplicating them and erasing them. Data like 'happiness' or 'sadness' are becoming abstractions because there is never a single moment when we can explicitly feel one or another. Let us click into these 'files' and explore these techno-cultural forms of communicational imperfection.
Decentralized Autonomous Housing
Authors: Onabolu Tolulope , Margariti Eleni 
Published: January 2020

Abstract
Decentralized Autonomous Organizations (DAOs) offer to disrupt all existing business models from derivatives trading to real estate, public services procurement and housing. This presents a unique opportunity for architects and urban designers to reshape the built environment by collectively engaging with finance generally, but also with alternative financial mechanisms, ahead of developers and investment companies who are less motivated by the quality of the built environment.
Emerging regimes of value in distributed autonomous systems
Authors: Nicolescu Razvan 
Published: January 2020

Abstract
This position article brings together perspectives from social sciences, computer science and economy to interrogate the emerging meanings of value produced by Distributed Autonomous Organizations (DAO). We explore this process in the context of the wider political economy enabled by Distributed Ledger Technologies (DLT) and Smart Contracts (SC). The article then questions the ways in which the current implementations of DAO reflect the various regimes of value and the emergent possibilities to rethink the social contract.
Trustless education? A blockchain system for university grades1
Authors: Rooksby John , Dimitrov Kristiyan 
Published: January 2020

Abstract
We have implemented a blockchain system based on Ethereum for use by a university to store student grades and to provide a cryptocurrency. Based upon an exploratory, qualitative evaluation we have found several tensions between the concept of a university as an organization and the concept of distributed autonomous organizations (DAOs) in Ethereum. These include tensions in (i) mechanisms of trust, (ii) boundaries of openness and (iii) values in procedures. In this article we outline our implementation and the evaluation process.
Recepcja myśli Carla Schmitta w USA po 1945 r.
Authors: Engelking Wojciech 
Published: January 2020

Wielu badaczy wskazuje na schmittiańskie inspiracje we współczesnej polityce Stanów Zjednoczonych. Jest to o tyle paradoksalne, że sam Carl Schmitt uznawał USA za państwo, którego system polityczny nie jest najlepiej przygotowany na przyjęcie filozofii decyzjonistycznej, pierwsze prace na jej temat w Stanach Zjednoczonych, również nie były zbyt życzliwe. W artykule omówiono, używając teorii wędrujących konceptów autorstwa niderlandzkiej badaczki Mieke Bal, w jaki sposób idee Carla Schmitta trafiły do USA. Wskazano na przeniesienie ich na grunt amerykański przez Hansa Morgenthau (który zastosował teorię Schmitta do stosunków międzynarodowych), Leo Straussa (który dokonał translacji jego politycznej teologii na polityczną filozofię) i myślicieli lewicowych skupionych wokół pisma „Telos”, którzy przeczytali Schmitta wbrew Schmittowi.
Reduction of entrepreneurial risk as the purpose of legislative initiatives: research results
Authors: Chmielnicki Paweł , Ingot-Brzęk Elżbieta , Styn Igor 
Published: January 2020

Artykuł dotyczy problemu długookresowych tendencji zachodzących w procesie stanowienia prawa w Polsce. Teoretycznym uzasadnieniem występowania takich tendencji jest założenie, że człowiek zwykle działa zgodnie z gotowymi schematami, zaakceptowanymi przez zbiorowość, które obejmują normy (reguły) należące do trzech podstawowych kategorii: (1) reguły dotyczące zdobywania dóbr za pomocą wymiany towarowo-pieniężnej, (2) reguły odnoszące się do pozyskiwania dóbr poprzez powołanie się na uprawnienia wynikające z przynależności do zbiorowości oraz (3) normy prawne, których rolą jest ochrona i upowszechnienie reguł należących do dwóch pierwszych kategorii. W rezultacie popyt na sposoby zaspokajania potrzeb determinowany określonymi regułami zwiększa podaż norm prawnych związanych z określonym zagadnieniem społeczno-gospodarczym. Skutkuje to pojawianiem się tendencji długookresowych w tworzeniu źródeł prawa, które można badać metodami empirycznymi, przedstawionymi w niniejszym artykule. W opracowaniu prezentowane są wyniki analiz dotyczących jednego z pytań badawczych, odnoszącego się do ważnego problemu społeczeństwa i gospodarki, jakim jest kwestia, czy regulacja ułatwia ocenę szans na osiągnięcie zakładanego celu gospodarczego, czy służy wzmacnianiu poczucia pewności obrotu gospodarczego, zmniejszeniu ryzyka niepowodzenia w działalności gospodarczej. We wnioskach zawarta jest teza, że zmniejszanie ryzyka przedsiębiorcy (przez regulacje bezpośrednie) jako trend w prawodawstwie systematycznie się umacnia. Analiza danych z badań pozwala zauważyć delikatny długoterminowy trend wzrostowy w ustawo-dawstwie, jeśli chodzi o zmniejszanie ryzyka gospodarowania przez przedsiębiorcę (w postaci regulacji bezpośrednio dotyczących tej tematyki). Można zauważyć, iż polski ustawodawca – w ujęciu długookresowym – kładzie duży, rosnący nacisk na tworzenie warunków do zmniejszania ryzyka obrotu gospodarczego.
Futsum Abbay, An Evaluation of Disability Human Rights Under the African Re-gional Human Rights System (Ocena przestrzegania praw człowieka względem osób niepełnosprawnych w ramach afrykańskiego systemu ochrony praw człowieka), „African Journal of International and Comparative Law” 2015, vol. 23, iss. 3
Authors: Staniszewska Lucyna 
Published: January 2020

Futsum Abbay, An Evaluation of Disability Human Rights Under the African Re-gional Human Rights System (Ocena przestrzegania praw człowieka względem osób niepełnosprawnych w ramach afrykańskiego systemu ochrony praw człowieka), „African Journal of International and Comparative Law” 2015, vol. 23, iss. 3
Are the biomedical sciences ready for synthetic biology?
Authors: DeNies Maxwell S. , Liu Allen P. , Schnell Santiago 
Published: January 2020

AbstractThe ability to construct a functional system from its individual components is foundational to understanding how it works. Synthetic biology is a broad field that draws from principles of engineering and computer science to create new biological systems or parts with novel function. While this has drawn well-deserved acclaim within the biotechnology community, application of synthetic biology methodologies to study biological systems has potential to fundamentally change how biomedical research is conducted by providing researchers with improved experimental control. While the concepts behind synthetic biology are not new, we present evidence supporting why the current research environment is conducive for integration of synthetic biology approaches within biomedical research. In this perspective we explore the idea of synthetic biology as a discovery science research tool and provide examples of both top-down and bottom-up approaches that have already been used to answer important physiology questions at both the organismal and molecular level.
Development of a Mathematics On-line Project in Engineering Education
Authors: Soares Filomena , Lopes Ana Paula , Cellmer Anna , Uukkivi Anne , Rebollar Carolina , Varela Concepcion , Feniser Cristina , Safiulina Elena , Bravo Eugenio , Kelly Gerald , Bilbao Javier , Cymerman Joanna , Brown Ken , Latõnina Marina , Labanova Oksana , Garcia Olatz , Bocanet Vlad 
Published: January 2020

Abstract
Embracing tertiary education system represents the beginning of a transition and adjustment period for several students. Most of these have just finished high school where the environment is strictly defined, controlled, stable and attendance is mandatory. Higher Education changes the role of students’ responsibility and this can cause stress and difficulty in the transition to self-directed learning and autonomy promotion. The purpose of this paper is to present an Erasmus+ project that brought together six Higher Education Institutions from different European countries and to describe its current stage. This project aims to develop a shared understanding of engineering mathematics at an early stage of tertiary education and to raise awareness of cultural, professional and educational issues. The initial focus of the work is on the partners’ mutual interest in active learning, particularly the application of Information and Communication Technology in the field of engineering education. When finalised, the project hopes to provide students with a new authentic engineering mathematics subject which meets their needs. This is also the core reason why the on-line course will be composed using innovative pedagogics and ICT tools, as appropriate pedagogics supports students’ procedural, conceptual and application understanding in mathematics and enhances digital competencies, literacy and skills.
Linking Photography and Mathematics with the Use of Technology
Authors: Rizzo Karina A. , del Río Laura S. , Manceñido Mónica E. , Lavicza Zsolt , Houghton Tony 
Published: January 2020

Abstract
In this paper, we describe an inclusive, collaborative learning approach in which both able and less able students engaged together in a contest combining Photography, Mathematics and Technology, in our case GeoGebra. Following three cycles of the contest, we analysed a selection of entries and the related post-participation survey. Based on the analysis, we concluded that the combination of these approaches could help to engage students with mathematical content by relating art, their surrounding environment with mathematics. This approach enabled us to offer different ways of mathematics learning through providing contexts for exploration and students’ creation of their own contents. Results also showed that school teaching is sometimes insufficient to solve emerging problems and this challenged students to find new kinds of solutions supported by new tools and concepts. It also allowed students to think creatively by inviting them to work together to develop their own questions, problems, and facilitating learning by research.
Mechanical properties and microstructural characteristics of friction stir welded AA2014-T6 aluminium alloy joints
Authors: Rajendran Chinnasamy , Srinivasan Kasi , Balasubramanian Visvalingam , Balaji Haridasu , Selvaraj Ponnumuthu 
Published: January 2020

AbstractThe quality of friction stir welded joints depends upon the working parameters such as rotational speed, welding speed, shoulder diameter, tilt angle; etc. Each process parameter has a significant effect on the formation of joint strength. This investigation attempts to understand the effect of friction stir welding parameters on microstructural characteristics and tensile strength of AA2014-T6 aluminium alloy. This is performed by changing any one of the process parameters from minimum to maximum and keeping others constant. The joint fabricated from a rotational speed of 1500 rpm, welding speed of 40 mm/min, shoulder diameter of 6 mm and tilt angle of 1.5∘ yielded superior tensile properties compared to their counter joints. Due to the formation of defect-free weld, balanced material flow and uniform distribution of strengthening precipitates in the stir zone is achieved.
Operationalizing and Measuring Rule of Law in an Internationalized Transitional Context: The Virtue of Venice Commission’s Rule of Law Checklist
Authors: Qerimi Qerim 
Published: January 2020

AbstractThis article will seek to operationalize and measure rule of law primarily relying on the “Rule of Law Checklist,” developed by the Venice Commission, composed of the following five elements: (1) Legality; (2) Legal certainty; (3) Prevention of abuse or misuse of powers; (4) Equality before the law and non-discrimination; and (5) Access to Justice. Each of these elements will be operationalized in the context of Kosovo – the leading case study – with an ultimate aim of obtaining an enhanced understanding of the Rule of Law framework and its measurement in transitional contexts more generally. The underlying circumstances of the selected case are defined by an almost unparalleled involvement of the international community, in particular the UN and the EU, which forms a relatively significant part of the observable context.