bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tillage practices and residue management manipulate soil bacterial and fungal assembly and co-occurrence network patterns in maize agroecosystem
Authors: Yang Wei , Guan Yupeng , Zhai Cheng , Du Lin , Wu Yanxiang , Wang Jing , Li Yuhang , Yang Jiayu , He Jinxi , Gu Siyu 
Published: March 2020

Abstract
Background: Tillage practices and residue management are highly important agricultural practices. However, very few studies have examined the influence of tillage practices and residue management on both bacterial and fungal communities and network patterns in consecutive years.
Results: We examined the effects of different tillage practices, including no tillage, rotary tillage, and deep tillage, on the soil bacterial and fungal communities and co-occurrence networks following residue removal and residue retention in 2017 and 2018. This study showed that both bacterial and fungal communities were unaffected by tillage practices in 2017, but they were significantly influenced in 2018. In addition, soil fungal operational taxonomic unit (OTU) richness was significantly enhanced by deep tillage compared with no tillage in 2018, while bacterial OTU richness was unaffected in either year. Tillage practices had differing effects on the soil microbial network patterns, with rotary and deep tillage increasing the complexity of bacterial networks but simplifying fungal networks. However, residue retention only induced a shift in the fungal community in 2018 without an obvious effect in the bacterial community in both years. In addition, residue retention simplified soil bacterial and fungal networks in 2018.
Conclusions: This study highlighted the dissimilar responses of bacterial and fungal networks to tillage practices and emphasized that tillage practice is more important than residue management in shaping soil microbial communities.
Improvement research on the initial solution prediction of the one-step algorithm for bus rollover collision
Authors: Wang Tong 
Published: March 2020

Abstract
To solve the problem that the computational efficiency of the initial solution prediction based on the maximum inertial loading in the original one-step algorithm for bus rollover collision is a bit low, a new initial solution prediction method based on the principle of nodal coordinates interpolation of the standard template of structural deformation is proposed to improve the original one-step algorithm for bus rollover collision. A typical 12-meter bus body section is selected as the research object, and the simulation result of the improved algorithm is compared with the original algorithm. The compare result shows that the computational precision of the improved algorithm is basically kept, and the computational efficiency is greatly improved. The effectiveness of practical engineering application of the proposed initial solution prediction method is verified.
Dynamical Analysis of Flexible Roll-Die Forming Machine
Authors: Li Qiang , Chen Xiao-Yu , Yang Zhen-Feng , Guan Yan-Zhi 
Published: March 2020

Abstract
The dynamical analysis is significant for the design of the flexible roll-die forming machine. A new method for dynamical analysis of electromechanical systems by energy principle is proposed in this paper. The mathematical expression of the energy in each part of the system is presented by theoretical analysis and mathematical deduction. The reaction torque in the process of roll-die forming are extracted by FEM, and the differential equation of the roll-die forming machine is solved by the method of Runge-Kutta. The designed roll-die forming machine with the analytical results performs the feasible experimental verification.
International relevance of Two Measures of Awareness of Age-Related Change (AARC)
Authors: Sabatini Serena , Ukoumunne Obioha C , Ballard Clive , Brothers Allyson , Kaspar Roman , Collins Rachel , Kim Sarang , Corbett Anne , Aarsland Dag , Hampshire Adam , Brooker Helen , Clare Linda 
Published: March 2020

Abstract
Background: A questionnaire assessing awareness of positive and negative age-related changes (AARC gains and losses) was developed in the US and Germany. We validated the short form of the measure (AARC-10 SF) and the cognitive functioning subscale from the 50-item version of the AARC (AARC-50) questionnaire in the UK population aged 50 and over.Methods: Data from 14,797 participants in the “blind for review” cohort were used to explore and confirm the psychometric properties of the AARC measures including: validity of the factor structure; reliability; measurement invariance across males and females and across individuals with and without a university degree; and convergent validity with measures of self-perception of aging and mental, physical, and cognitive health. We also explored the relationship between demographic variables and AARC.Results: We confirmed the two-factor structure (gains and losses) of the AARC-10 SF and the AARC-50 cognitive functioning subscale. Both scales showed good reliability and convergent validity. The meaning of AARC gains and losses was the same across males and females and across individuals with and without a university degree. Items composing AARC scales had the same meaning across individuals with and without a university degree. Items composing the AARC-50 cognitive functioning subscale had the same meaning across males and females. Two items in the AARC-10 SF had different meaning across males and females. Demographic variables significantly predicted AARC gains and losses.Conclusions: The AARC-10 SF and AARC-50 cognitive functioning subscale can help to identify UK individuals who perceive age-related changes in their mental, physical, and cognitive health.
Comparison of Clinical Features in Octogenarian and Non-octogenarian Adults with Severe COVID-19 Pneumonia
Authors: Shu Chang , Liu Xianling , Yu Bilian , Yang Lizhen , Zhang Hong , Huang Guxiang , Tang Liang , Xu Min , Zhou Jienan , Xiao Le , Zhang Lei , Tang Jianjun , Li Xin 
Published: March 2020

Abstract
Background: Aged people is more susceptible and vulnerable to COVID-19 pneumonia. As the “super-elderly” group, octogenarian COVID-19 patients is not rare in current world-wide common healthy event.Object: To describe clinical features in octogenarian with severe COVID-19. And try to find out the differences with other non-octogenarian adult patients.Materials and Methods: We studied a small cohort of octogenarian COVID-19 patients at a hospital in Wuhan from 10 February to 15 March. We recorded interested clinical data including chest CT in the octogenarian patients. In order to know the differences of clinical characteristics between octogenarian and other adult patients, we included the number of non-octogenarian patients cohort as ratio of 1:3.Result: For octogenarian patients, the age is 83.33±3.08 and 4 are female (4/6,66.7%). For non-octogenarian patients, the age is 60.72±8.28 years and 5 are female(5/18, 27.8%). and 59% were men. Compared non-octogenarian patients, octogenarian patients’ hospital stay duration is significantly longer (p=0.0052*). WBC is obvious elevated in octogenarian(p=0.0494*). BUN (p=0.0377*) and Cr (p=0.0112*) is with obvious differences between two group patients. No obvious differences in CT findings between two groups.Conclusion: The severe COVID-19 pneumonia octogenarian may have more chance to combined with bacterial infection. Octogenarian has worse baseline kidney function than non-octogenarian. In individual cases, the broader lesion and more lesion types may be found in octogenarian CT image.
Deciphering the metabolism/vascularization regional interlinks in primary NSCLC First-in human simultaneous full kinetic 18F-FDG PET-MRI voxel-wise analysis
Authors: Besson Florent L , Fernandez Brice , Faure Sylvain , Mercier Olaf , Seferian Andrei , Mignard Xavier , Mussot Sacha , Péchoux Cécile le , Caramella Caroline , Botticella Angela , Levy Antonin , Parent Florence , Bulifon Sophie , Montani David , Mitilian Delphine , Fadel Elie , Planchard David , Besse Benjamin , Ghigna-Bellinzoni Maria-Rosa , Comtat Claude , Lebon Vincent , Durand Emmanuel 
Published: March 2020

Abstract
Objectives: To decipher the metabolism/vascularization regional interlinks in NSCLC, by using full dynamic simultaneous 18F-FDG PET-MRI voxel-wise analysis. Material and methods: Fourteen treatment-naïve patients with biopsy proven NSCLC prospectively underwent a one-hour dynamic 18F-FDG thoracic PET-MRI including DCE. The PET and DCE data were normalized to a reference space, and masked semi-automatically. Full kinetic voxelwise parametric maps were computed by fitting the PET and DCE tumor data to state-of-the-art Sokoloff and Extended Tofts models respectively, by using in-house procedures. Spearman correlation coefficients (rs) between all the tumors kinetic parameters were estimated on a voxelwise basis, both at the whole dataset and tumor levels.Results: At the whole dataset level, the estimated K1, k2, k3, MRGlu and vb median values (IQR) were 0.25ml.min-1.ml-1 (0.17-0.33), 0.68 min-1 (0.48-1.02), 0.11 min-1 (0.07-0.2), 0.20 μmol.ml-1.min-1 (0.13-0.29) and 0.08 a.u (0.05-0.10). The estimated Ktrans, ve, Kep and vp median values (IQR) were 0.44 min-1 (0.14-0.92), 0.64 a.u (0.24-1.0), 0.79 min-1 (0.44-1.3), and 0.04 a.u (0.0007-0.19). At the whole dataset level, all the PET/DCE regional interlinks were weak (|rs| <0.4). At the tumor level, high heterogeneity was observed: 8 tumors showed weak (|rs| <0.4) to moderate (0.4≤ |rs| <0.7) PET/DCE regional interlinks, 5 tumors showed weak to strong interlinks, and 1 tumor showed moderate to strong interlinks. Conclusion: Metabolism/vascularization regional interlinks assessed with dynamic 18F-FDG PET-MRI are spatially and individually heterogeneous in NSCLC. In the era of precision medicine, PET-MRI has unique capability to go further insight the individual regional tumor being in NSCLC.
CFTR deficiency causes cardiac dysplasia during zebrafish embryogenesis and is associated with dilated cardiomyopathy
Authors: Liu Yanyan , Lin Ziyuan , Liu Mingfeng , Liao Huijuan , Chen Yan , Zhang Xiaohu , Chan Hsiao Chang , Zhou Bin , Rao Li , Sun Huaqin 
Published: March 2020

Abstract
Background: Mutations in the CFTR gene cause cystic fibrosis (CF) with myocardial dysfunction. However, it remains unknown whether CF-related heart disease is a secondary effect of pulmonary disease, or an intrinsic primary defect in the CF heart. Results: Here, we used a zebrafish model, which lacks lung tissue, to investigate the role of CFTR in cardiogenesis during embryonic development. Our findings demonstrate that a loss of CFTR impairs cardiac development from the cardiac progenitor stage of heart development, resulting in cardiac looping defects, a dilated atrium, pericardial edema, and a decrease in heart rate. Furthermore, we found that cardiac development is perturbed in wild type embryos treated with a gating speciﬁc Cftr channel inhibitor, CFTRinh-172, at the blastula stage of development, but not with treatment at later stages. Gene expression analysis of blastulas indicated that transcript levels, including mRNAs associated with cardiovascular diseases, were significantly altered in embryos derived from cftr mutants relative to controls. To evaluate the role of CFTR in human heart failure, we performed a genetic association study on individuals with dilated cardiomyopathy and found that CFTR containing I556V mutation, which causes a channel defect, is associated with the disease. Similar to well-studied channel-defective CFTR mutants, CFTR I556V mRNA failed to restore cardiac dysplasia in mutant embryos. Conclusions: The present study reveals an important role for the CFTR ion channel in regulating cardiac development during early embryogenesis, supporting the hypothesis that CF-related heart disease results from an intrinsic primary defect in the CF heart.
The novel coronavirus (COVID-19) pneumonia with negative detection of viral ribonucleic acid from nasopharyngeal swabs: A case report
Authors: Zhang Peiyan , Cai Zhao , Wu Weibo , Peng Ling , Li Yinfeng , Chen Chuming , Chen Li , Li Jianming , Cao Mengli , Feng Shiyan , Jiang Xiao , Yuan Jing , Liu Yingxia , Yang Liang , Wang Fuxiang 
Published: March 2020

Abstract
BackgroundThe novel coronavirus disease 2019 (COVID-19) outbreak started in Wuhan, Hubei, China since Dec 2019 and cases of infection have been continuously reported in various countries. It is now clear that the COVID-19 coronavirus is transmissible from human to human. Nucleic acid detection is considered as the gold standard for the diagnosis of COVID-19. In this case report, we describe our experience in detection of COVID-19 from a confirmed patient using nucleic acid test of bronchoalveolar-lavage fluid (BALF) samples but not nasopharyngeal swabs.Case presentationWe present a case of severely ill COVID-19 infected 46-year-old man with fever, coughing and chest tightness. We performed viral detection using his BALF samples and imaging method (CT) for confirmation. The patient received combination of interferonalfa-1b and ribavirin, lopinavir and ritonavir for antiviral treatment at different stages. Other medication was also given to him in combination for anti-inflammation, intestinal microbial regulation, phlegm elimination, liver protection and pulmonary fibrosis prevention purposes. We provided oxygen supply to him using BIPAP ventilator and high-flow humidification oxygen therapy instrument to facilitate respiration. The patient was cured and discharged.ConclusionThis case report described an effective supportive medication scheme to treat COVID-19 infected patient and emphasized the necessity of detection of the viral genome using BALF samples and its significance in the diagnosis and prognosis of the disease.
Social gradient in health-related quality of life among urban residents in Limassol, Cyprus: Research article
Authors: Ellina Panagiota , Middleton Nicos , Lambrinou Ekaterini , Kouta Christiana 
Published: March 2020

Abstract
Background Social inequalities in health threaten social cohesion and, therefore, their investigation is an important research field. The reasons behind this phenomenon remain unclear. Monitoring the health of the population is necessary to identify health needs, design programs focused in people’s needs and to evaluate the effectiveness of health policies. Methods A descriptive correlation study with cross-sectional comparisons using primary data was applied. The study investigates the size and the extent of social inequalities in quality of life and health behaviours in Limassol, Cyprus. Data collection was done by door-to-door survey, in the form of interviews. The sample consisted of 450 residents aged 45-64 across 45 randomly selected neighbourhoods, that met the selection criteria. The tools used were: Demographic questionnaire, SF 36 Questionnaire - Quality of Life, IPAQ- International Physical Activity Questionnaire short form. Results The social gradient seems to be appeared in all social indicators. As for the physical dimension of health, it seems to show strong relationship between quality of life with the education index. Regarding mental health dimension, the pattern of social gradient seems to be not so strong. Conclusions Exploring social inequalities in quality of life, is a complex state influencing social physical and psychological state of health. It seems that being male, young, highly educated, with high income, working full time and having a mild physical activity, there is significant higher level of quality life in relation to others. Many studies show that gender affects the patterns of risk factors and that this has a different impact on quality of life.
Coverage and effectiveness of hypertension screening in different altitudes of Tibet autonomous region
Authors: Song Ci , Chongsuvivatwong Virasakdi , Wangdui Suolang , Mima Danzeng , Zhuoma Cuoji , Ji De , Luobu Ouzhu , Sripl Hutcha 
Published: March 2020

Abstract
Background: Tibet is an autonomous region in China located around an average altitude of 4,500 meters above sea level. Since 2012 the local government of Tibet has been providing free physical examinations, including screening for hypertension. However, the coverage and effectiveness of this free program have not uncovered. This study aims to assess the coverage and effectiveness of hypertension screening and management program in 3 altitude levels of Tibet, and also the determinants of the success of the screening program. Methods: A stratified cluster survey was conducted among 1,636 residents aged 18 years or over in three different altitude areas in Tibet. We adjusted for age and sex based on national census data and used weighted logistic regression models to find factors associated with hypertension screening. Results: The coverage of the hypertension screening program evaluated by participation rate in the previous screening was 94.9%, while 24.7% (95% CI: 22.1-27.3) of them were diagnosed with hypertension. Females and alcohol drinkers were more likely to be screened. Among those diagnosed with hypertension, 28.7% had it under control. High altitude areas had a high proportion of controlled hypertension. The overall rate of controlled hypertension in high, moderate and low altitude areas was 35.1% (95% CI: 24.8-45.3), 32.7% (95% CI: 22.2-43.2) and 23.7% (95% CI: 14.7-32.6), respectably. Younger aged persons were more likely to have better control of their hypertension. Conclusions: The coverage of hypertension screening in Tibet was high, especially in the low altitude areas. However, the effectiveness of hypertension control was low, indicating a need to improve interventions.
The Psychological Impact of the Ebola epidemic among Survivors in Liberia: a retrospective cohort study
Authors: Nyanfor Simmie Segbe , Xiao Shuiyuan 
Published: March 2020

Abstract
Background The 2013- 2016 West Africa Ebola epidemic resulted in an unprecedented number of survivors. The outbreak has contributed to many survivors, who have shown to have suffered from physical and mental sequelae – sigma, physical violence, diminished quality of life, ostracism, and isolation. The goal of this study was to evaluate the relationship between Ebola virus disease and long-term psychological problems among Ebola survivors in Liberia. Method In January 2019, quantitative data from 232 respondents (EVD survivors, n = 116; non-survivors, n = 116) were gathered by structured face-to-face interviews. We used Davidson Trauma Scale for PTSD (DTS), the Generalized Anxiety Disorder Scale (GAD-7) to assess anxiety, the Patient Health Questionnaire (PHQ-9) to assess depression, and the Suicide Behavior Questionnaire-Revised (SBQ-R) to assess suicidality of both the survivors and their controls. Data were analyzed by linear regression analyses, chi-square, or t-tests to determine the prevalence, Ebola virus infection, and factors associated with long term psychological problems among EVD survivors and non-survivors. Results We have identified 116 survivors of EVD and 116 non-Ebola survivors. Of the 116 people who survived, 76 (66%) recorded posttraumatic stress disorder, 61 (53%) depression, 43 (37%) anxiety, and 39 (34%) attempted suicide. Relative to EVD survivors, the non-survivors had very significantly lower levels of posttraumatic stress disorder, 7(6%), depression, 5 (4%), anxiety, 5 (4%), and 2 (2%) attempted suicide reported three years after the outbreak. In a logistic regression analysis, EVD survivors had higher odds of observing posttraumatic stress disorder ( β =3.39, OR, 29.59 [95% Cl 2.53, 4.24]; p<.001), depression ( β = 3.20 OR, 24.62 [95% Cl 2.24, 4.17]; p <.001); anxiety ( β = 2.57, OR, 13.08 [95% Cl 1.60, 3.54]; p <.001), and suicidality (β = 3.36, OR, 28.87 [95% Cl 1.91, 4.81], p <.001) three years after the outbreak. Conclusion Three years after the outbreak, EVD survivors still had persistently high levels of posttraumatic stress disorder, depression, anxiety, and suicide attempt. The long-term psychological implications of infectious diseases should not be ignored. The results underscore the need for Mental Health services on a national scale for the EVD survivors.
Design and research of a smart monitoring system for 2019-nCoV infection-contact isolated people based on blockchain and Internet of things technology
Authors: Zheng Ling , Xiao Chunjian , Chen Fei , Xiao Yonghong 
Published: March 2020

Abstract
Objective: In order to cope with a sudden outbreak of new coronavirus infection, a large number of potential infected persons need to be isolated. A new smart monitoring system which integrates Internet of things and blockchain technology to monitor isolated people in real time was design and studied.Methods: A internet of things devices will collects the location and physical data of isolated people, the data will be sent to master devices which will integrate and format those data and transfer to a smart contract. A smart contract compares and analyses the data with the threshold which is predefined. When the data exceed the threshold, the smart contract will alert the master device, which will notify the isolated person and center for disease control and prevention, the event will be stored in the consortium blockchain. The blockchain does not store the isolated people's details, which are stored in electronic health records linked to the blockchain to guarantee the data safety.Results: This system realizes the effective real-time monitoring of isolators including their physical condition and geographical position on the premise of protecting their privacy and security.Conclusion: By the system, the center for disease control and prevention can respond quickly according to their alerts. It has the advantages of good integrity, tamper-proof, and transparency to isolators.
Modified FOLFIRINOX as a second-line therapy following gemcitabine plus nab-paclitaxel therapy in metastatic pancreatic cancer
Authors: Sawada Masashi , Kasuga Akiyoshi , Mie Takafumi , Furukawa Takaaki , Taniguchi Takanobu , Takeda Tsuyoshi , Kanata Ryo , Matsuyama Masato , Sasaki Takashi , Ozaka Masato , Sasahira Naoki 
Published: March 2020

Abstract
Purpose There is no established second-line treatment after failure of gemcitabine plus nab-paclitaxel (GnP) therapy for metastatic pancreatic cancer (MPC). This study aimed to evaluate the efficacy and tolerability of the modified FOLFIRINOX (mFFX) as a second-line therapy for MPC and investigate prognostic factors for survival.Methods From 2015–2019, we retrospectively reviewed the medical records of patients receiving mFFX for MPC after failure of GnP therapy. Patients were treated every 2 weeks with mFFX (intravenous oxaliplatin 85 mg/m2, intravenous irinotecan 150 mg/m2, and continuous infusion of 5-fluorouracil 2,400 mg/m2 for 46 hours without bolus infusion) until disease progression, patient refusal, or unacceptable toxicity.Results In total, 104 patients received mFFX. The median overall survival (OS) was 7.0 months (95% confidence interval [CI]: 6.2-9.8) and the progression-free survival (PFS) 3.9 months (95% CI 2.8-5.0). The objective response rate was 10.6% and the disease control rate 56.7%. The median relative dose intensities of oxaliplatin, irinotecan, and infusional 5-FU were 80.0% (range 21.5-100%), 77.2% (range 38.1-100%), and 85.9% (range 36.9-100%), respectively. Grade 3-4 toxicities were reported in 57 patients (54.8%), including neutropenia, leukopenia, anemia, febrile neutropenia, and peripheral sensory neuropathy. Glasgow prognostic score and carcinoembryonic antigen level were independently associated with survival. Our prognostic model using these parameters could classify the patients into good (n = 38), intermediate (n = 47), and poor (n = 19) prognostic groups. The median OS and PFS time was 14.7 (95% CI 7.6-16.3) and 7.6 months (95% CI 4.1-10.5) for the good prognostic factors, 6.5 (95% CI 5.5-10.0) and 3.6 months (95% CI 2.7-4.8) for the intermediate prognostic factors and 5.0 (95% CI 2.9-6.6) and 1.7 months (95% CI 0.9-4.3) for the poor prognostic factors, respectively.Conclusions The mFFX showed to be a tolerable second-line treatment for MPC after GnP failure. Our prognostic model might be useful for deciding whether mFFX is indicated in this setting.