bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic potential of mesenchymal stem cells and their exosomes in severe novel coronavirus disease 2019 (COVID-19) cases
Authors: Tsuchiya Atsunori , Takeuchi Suguru , Iwasawa Takahiro , Kumagai Masaru , Sato Takeki , Motegi Satoko , Ishii Yui , Koseki Youhei , Tomiyoshi Kei , Natsui Kazuki , Takeda Nobutaka , Yoshida Yuki , Yamazaki Fusako , Kojima Yuichi , Watanabe Yusuke , Kimura Naruhiro , Tominaga Kentaro , Kamimura Hiroteru , Takamura Masaaki , Terai Shuji 
Published: June 2020

AbstractThe novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19) and the ensuing worldwide pandemic. The spread of the virus has had global effects such as activity restriction, economic stagnation, and collapse of healthcare infrastructure. Severe SARS-CoV-2 infection induces a cytokine storm, leading to acute respiratory distress syndrome (ARDS) and multiple organ failure, which are very serious health conditions and must be mitigated or resolved as soon as possible. Mesenchymal stem cells (MSCs) and their exosomes can affect immune cells by inducing anti-inflammatory macrophages, regulatory T and B cells, and regulatory dendritic cells, and can inactivate T cells. Hence, they are potential candidate agents for treatment of severe cases of COVID-19. In this review, we report the background of severe cases of COVID-19, basic aspects and mechanisms of action of MSCs and their exosomes, and discuss basic and clinical studies based on MSCs and exosomes for influenza-induced ARDS. Finally, we report the potential of MSC and exosome therapy in severe cases of COVID-19 in recently initiated or planned clinical trials of MSCs (33 trials) and exosomes (1 trial) registered in 13 countries on ClinicalTrials.gov.
Small RNA derived from Tobacco mosaic virus targets a host C2-domain abscisic acid-related (CAR) 7-like protein gene
Authors: Guo Song , Wong Sek-Man 
Published: June 2020

AbstractTobacco mosaic virus (TMV) is a positive-sense single-stranded RNA virus. The 3′ end of TMV genome is consisted of an upstream pseudoknot domain (UPD) and a tRNA-like structure (TLS), both of which are important RNA elements to enhance TMV replication and translation. Deep-sequencing analysis revealed that TMV-specific viral small interfering RNAs (vsiRNAs) were generated in TMV-infected Nicotiana benthamiana plants. A vsiRNA derived from the juxtaposition between UPD and TLS, named TMV-vsiRNA 22 nt (6285–6306), possessed high sequence complementarity to a host gene which encodes a C2-domain abscisic acid (ABA)-related (CAR) 7-like protein. CAR proteins play a critical role in ABA signaling pathway. The CAR protein-encoding gene was amplified from N. benthamiana leaves and termed as Nb-CAR7. In TMV-infected plants, accumulation of Nb-CAR7 transcripts was significantly decreased, as compared with that of mock-inoculated and TMV-43A-infected plants. TMV-43A is a mutant without the UPD sequence in its genome. Overexpression of Nb-CAR7 led to decreased TMV RNA accumulation in the TMV-inoculated leaves. Silencing of Nb-CAR7 enhanced TMV replication and resulted in a higher viral RNA accumulation. In addition, the expression level of Nb-CAR7 was positively correlated to that of a low-temperature-induced ABA responsive gene (LTI65). The effect of Nb-CAR7 on TMV RNA accumulation in host plants was linked to ABA signaling pathway. In conclusion, a vsiRNA derived from the juxtaposition between UPD and TLS at the 3′UTR of TMV targets a host CAR7 gene.
Site-1 protease ablation in the osterix-lineage in mice results in bone marrow neutrophilia and hematopoietic stem cell alterations
Authors: Patra Debabrata , Kim Joongho , Zhang Qiang , Tycksen Eric , Sandell Linda J. 
Published: June 2020

ABSTRACT
Site-1 protease (S1P) ablation in the osterix-lineage in mice drastically reduces bone development and downregulates bone marrow-derived skeletal stem cells. Here we show that these mice also suffer from spina bifida occulta with a characteristic lack of bone fusion in the posterior neural arches. Molecular analysis of bone marrow-derived non-red blood cell cells, via single-cell RNA-Seq and protein mass spectrometry, demonstrate that these mice have a much-altered bone marrow with a significant increase in neutrophils and Ly6C-expressing leukocytes. The molecular composition of bone marrow neutrophils is also different as they express more and additional members of the stefin A (Stfa) family of proteins. In vitro, recombinant Stfa1 and Stfa2 proteins have the ability to drastically inhibit osteogenic differentiation of bone marrow stromal cells, with no effect on adipogenic differentiation. FACS analysis of hematopoietic stem cells show that despite a decrease in hematopoietic stem cells, S1P ablation results in an increased production of granulocyte-macrophage progenitors, the precursors to neutrophils. These observations indicate that S1P has a role in the lineage specification of hematopoietic stem cells and/or their progenitors for development of a normal hematopoietic niche. Our study designates a fundamental requirement of S1P for maintaining a balanced regenerative capacity of the bone marrow niche.
BENEFITS OF INCORPORATING HIIT PROGRAMS FOR INDIVIDUALS WITH DOWN SYNDROME
Authors: Ware Megan E. , McCully Kevin K. , Feito Yuri 
Published: June 2020

Apply It!
• Health and fitness professionals will be able to use the information in this article to design exercise prescription programs for people with Down syndrome.
• Health and fitness professionals will be able to approach a client with Down syndrome with more background knowledge of the condition itself.
QUARTIC: QUick pArallel algoRithms for high-Throughput sequencIng data proCessing
Authors: Jarlier Frédéric , Joly Nicolas , Fedy Nicolas , Magalhaes Thomas , Sirotti Leonor , Paganiban Paul , Martin Firmin , McManus Michael , Hupé Philippe 
Published: June 2020

Life science has entered the so-called 'big data era' where biologists, clinicians and bioinformaticians are overwhelmed with high-throughput sequencing data. While they offer new insights to decipher the genome structure they also raise major challenges to use them for daily clinical practice care and diagnosis purposes as they are bigger and bigger. Therefore, we implemented a software to reduce the time to delivery for the alignment and the sorting of high-throughput sequencing data. Our solution is implemented using Message Passing Interface and is intended for high-performance computing architecture. The software scales linearly with respect to the size of the data and ensures a total reproducibility with the traditional tools. For example, a 300X whole genome can be aligned and sorted within less than 9 hours with 128 cores. The software offers significant speed-up using multi-cores and multi-nodes parallelization.
Case Report: Acute effect of benralizumab on asthma exacerbation without concomitant corticosteroid use
Authors: Nolasco Santi , Campisi Raffaele , Intravaia Rossella , Porto Morena , Pelaia Corrado , Crimi Nunzio , Crimi Claudia 
Published: June 2020

Background: Monoclonal antibodies are a relatively new therapeutic option for patients with severe refractory asthma, which can be used as an add-on to maintenance therapy, reducing the need for systemic corticosteroid usage, improving asthma symptom control and reducing exacerbations. We report a case of a patient with severe refractory eosinophilic asthma, reluctant to take systemic steroids, who was successfully treated with benralizumab alone during an acute asthma attack. Case presentation: A 59-year-old Caucasian woman with a history of allergic asthma since childhood showed a progressive decline in lung function with difficult to control symptoms and an increased number of hospitalizations despite maximal maintenance treatment, and was diagnosed with severe refractory asthma. She was reluctant to take systemic corticosteroids during exacerbations due to severe urinary retention; therefore, she started omalizumab with a partial reduction of symptoms and exacerbations over time. During a follow-up visit, she showed signs of acute exacerbation and she was switched to benralizumab during her acute phase with a rapid, dramatic amelioration of respiratory symptoms and pulmonary function, without concomitant systemic corticosteroid administration. During the treatment and at follow-up after one month, good tolerance and no side effects were observed. Conclusions: The use of benralizumab seems to be feasible, rapid, and safe in treating acute exacerbation of severe eosinophilic asthma without the use of systemic corticosteroids.
Nierząd i inne „grzechy ohydne” w tłumaczeniach Biblii: eufemizacje i retusze w Mt 5,32, Mt 9,19 i Kpł 20,10-21
Authors: Brzozowski Jerzy 
Published: June 2020

Fornication and Other “Awful Sins” in the Bible Translations. Euphemisms and Alterations on Matt 5:32, 9:19 and Lev 20:10-21
The paper shows confusion of theologians – both catholic and protestant – in all Polish and many other translations of fragments related to sexual relations, especially these contacts which were recognised uniquely as a cause of divorce. The considered translations tend to use archaic, euphemistic or imprecise vocabulary in the main text, adding often confusing and linguistically unacceptable footnotes. On the contrary, the analysed Italian and French translations are clear and intelligible. The Author shows, nevertheless, that the existing translations – not only in Polish, but also in Italian and French – of the Greek word porneia used in the Gospels are incoherent with those in the Old Testament, which is unacceptable. The Author also claims, on the basis of analysed texts, that even the best footnotes cannot replace a clear and intelligible translation in the main text.
The “Debate” about Poland
Authors: Sofizade Jessica 
Published: June 2020

This paper examines two speeches made by Janusz Lewandowski and Ryszard Antoni Legutko in the European Parliamentary debate entitled “The situationof the rule of law and democracy in Poland” on 15/11/2017. In particular, it analyses their representations of Poland and the EU, and aims to determine whether they can be considered as “populist” according to J.-W. Müller’s criteria of populism. It is suggested that Legutko’s speech can be labelled populist according to Müller’s criteria, whilst Lewandowski does not face this charge to the same extent, even though his speech uses similar linguistic methods.
Editorial: The Power of Safety Professionals to Effect Change
Authors: Myers Melvin L. 
Published: June 2020

Abstract. In 2006, Cole et al. (2006) reported on tractor overturn-related injuries in Kentucky from a random sample of farmers that numbered 6,063 respondents. The highest number of people who experienced tractor overturns were operators 16 to 20 years old. In 2007, at a National Institute for Occupational Safety and Health (NIOSH) Tractor Safety Initiative meeting in Colorado, John Myers of NIOSH presented a map of the states with the highest overturn fatality rates: Tennessee, Kentucky, West Virginia, Ohio, Pennsylvania, and Illinois. Significantly, four of these states, including Kentucky, overlap the Appalachian region (Cole, 2007; Hard and Myers, 2001). In Kentucky, this region involves farming on slopes, as examined by Saman et al. (2012), who found a high-risk cluster of tractor overturns among ten Kentucky counties in the Appalachian region, with a 97% increased risk of overturn as compared to other Kentucky counties. In 1971, James Arndt of Deere &amp; Company presented a 50-year review of rollover protective structures (ROPS) at a Society of Automotive Engineers (SAE) conference. Arndt (1971) estimated that, over the previous 50 years, 30,000 operators had been killed when crushed by tractor overturns in agriculture and construction work. Since then, ROPS have been recognized as an effective device to prevent death in the event of a tractor overturn (Reynolds and Groves, 2000). Nevertheless, the epidemic of tractor-related deaths has continued into the modern era, and the cost of ROPS has been found to be a significant barrier to retrofitting tractors that lack ROPS (Myers et al., 1998). To provide a low-cost alternative, NIOSH safety engineers have designed, tested, and provided instructions for building and fitting cost-effective ROPS (CROPS) onto pre-ROPS tractors (i.e., tractors built before 1968) (Hard et al., 2016). Keywords: NIOSH, ROPS, Tractor overturns, Tractor safety.
“I Have Never Had A PBL Like This Before”
Authors: Gomoll Andrea S. , Hillenburg Becky , Hmelo-Silver Cindy E. 
Published: June 2020

Video and co-design can be powerful tools to enrich problem-based learning experiences. We explore how a teacher and researcher engaged in co-design of a PBL experience focused on human-centered robotics as well as the resulting design. They explored the question “How can we design a robot that serves a need in our local community?” We highlight three aspects of the most recent iteration of our PBL curriculum that we have identified as central to its success. These three elements include: 1) co-design experiences that occurred before and during unit implementation, 2) the use of shared video viewing and analysis both in co-design and with student groups in the classroom, and 3) the bringing of local stakeholders into the classroom to work closely with students. These three aspects of our curriculum are positioned here as takeaways for researchers and educators working to design, implement, and study PBL.
Acknowledgments: This research was supported by the National Science Foundation through ITEST grant #1433414. Any opinions, findings, conclusions, or recommendations expressed in this report are those of the authors, and do not necessarily represent the official views, opinions, or policy of the National Science Foundation. A special thanks to Dr. Selma Šabanovic, principal investigator, and Dr. Matt Francisco for their contributions to this work.
Probabilistic reduction in relation to social message predictability
Authors: Hashimoto Daiki 
Published: June 2020

AbstractLanguage is a system of message transmission, which conveys a variety of messages including both lexical messages and social messages. It has been demonstrated that lexical messages are realized with phonetically reduced signals, when they are contextually predictable. For example, a word may be produced with shorter duration, when it is more predictable given a context such as a preceding word and a following word. This message-oriented reduction can be encapsulated by positing that a speaker is required to balance two biases: a bias for maximizing the accuracy of message transmission and a bias for maximizing the efficiency of message transmission. This raises a question: Does a speaker balance the two biases in relation to social messages? The aim of this study is to address this question, and advance our understanding of the message-oriented probabilistic reduction. We will explore the social-message-predictability effects by examining the phonetic redundancy in a variant in New Zealand English loanword phonology, a tap sound [ɾ]. It is demonstrated that the duration of this rhotic variant is affected by the social message predictability given a loanword.
Magnum opus: urbanismo, arquitectura y revalorización patrimonial de la planta de baterías de cok y subproductos de ENSIDESA (Avilés)
Authors: Domínguez Rodríguez Rubén 
Published: June 2020

RESUMEN:La planta de baterías de hornos de cok y subproductos de la Empresa Nacional Siderúrgica S.A. domina desde mediados del siglo XX el nuevo paisaje industrial de la ciudad de Avilés (Asturias). Las baterías combinan en sus planteamientos urbanísticos y arquitectónicos valores funcionales y estéticos propios del Movimiento Moderno, que por su calidad y trascendencia le han conferido un interés patrimonial reconocido, junto al resto de instalaciones de la factoría, mediante su inclusión en el Plan Nacional de Patrimonio Industrial. Tras su cese productivo en el año 2019 diversas instituciones científicas han manifestado la necesidad de conservar y dotar de nuevos usos la coquería, los edificios de almacenaje y talleres auxiliares y la maquinaria, como testimonio material de uno de los proyectos más ambiciosos y valiosos del Instituto Nacional de Industria. Palabras clave: Patrimonio industrial; siderurgia; Avilés; arquitectura; movimiento moderno.
Serum uric acid level in Bangladeshi adults with essential hypertension
Authors: Ahammed SK. Kabir , Hasan A. B. M. Kamrul , Kabir Mohammed Ruhul , Paul Gunosindhu , Basak Shishir Kumar , Chakraborty Shishir Ranjan , Islam A.F.M. Nazmul 
Published: June 2020

Background: The association of hyperuricemia with various cardiovascular risk factors has often led to the debate of whether hyperuricemia is an independent risk factor for essential hypertension (HTN). The current study was conducted to see the relationship between serum uric acid and essential HTN in Bangladeshi adults.Methods: In this cross-sectional study, conducted in a tertiary hospital of Bangladesh, 155 patients with essential hypertension (newly detected or on treatment) aged ≥18 years and 100 age-sex matched normotensive subjects were investigated. Serum uric acid, plasma glucose, serum creatinine, and lipid profile were measured in all in fasting samples.Results: The frequency of hyperuricemia was higher in the hypertensive group in comparison to the normotensive control group (29.7% vs. 6.0%, p<0.001). Serum uric acid level was higher in the hypertensive subjects than the controls (6.10±0.88 vs. 5.38±0.54 mg/dL, mean±SD, p<0.001). In the hypertensive group, subjects with stage II HTN had higher serum uric acid than those with stage I HTN (6.46±0.83 vs. 5.72±0.78 mg/dL, mean±SD, p<0.001). In the hypertensive group, uric acid level showed significant positive correlations with both systolic and diastolic blood pressure though in the control group uric acid showed such correlation with systolic BP only.Conclusion: Patients with essential hypertension had higher serum uric acid compared to normotensive controls; uric acid level showed positive correlations with systolic and diastolic BP in the hypertensive subjects.
Yıldırım çarpması sonrası hayatta kalan bir olgunun adli-tıbbi değerlendirmesi
Authors: KAYA Ahsen , ÖZÇALIŞKAN Burcu , TEMÜRKOL Selen Can , ATA Uğur 
Published: June 2020

Yıldırım; ölümle sonuçlanabilen ve en sık karşılaşılan hava kaynaklı doğa olayı olup anlık, atmosferik, geçici, yüksek akımlı elektriksel deşarj olarak tanımlanmaktadır. Bu çalışmada; yıldırım çarpması sonrası hayatta kalan olgunun bulgularının literatür eşliğinde tartışılması ve adli-tıbbi yönden değerlendirilmesi amaçlandı.
Nisan 2018’de askerlik hizmetini yaparken, yağmurlu bir havada, 2000 metre yükseklikte, açık alanda yıldırım çarpması sonucu yaralanan 28 yaşındaki erkek olgu, polikliniğimize adli raporunun düzenlenmesi için başvurdu. Olay tarihli tıbbi evrakında, alt ve üst ekstremitelerde yanık alanları, nonspesifik EKG değişiklikleri, karaciğer fonksiyon testi yüksekliği ve sol testiste inflamasyon bulguları olduğu yazılıydı. Olaydan sekiz ay sonra tarafımızca yapılan muayenesinde skar dokuları dışında başka bir bulgu saptanmadı.
Literatürde, yıldırım çarpması sonucu meydana gelen bulgular daha çok otopsi bulguları ile sınırlıdır. Yıldırım çarpması sonrası hayatta kalan bu olgunun bulgularının literatüre katkı sağlayacağı düşünüldü.
Çocuk nöroloji bölümüne baş dönmesi şikâyeti ile konsülte edilen hastaların retrospektif değerlendirmesi
Authors: YILDIRIM Miraç , DOĞAN Melih Timuçin , KEÇELİ Avni Merter 
Published: June 2020

Amaç: Çocukluk çağında baş dönmesi geniş etiyolojik spektrumu ile pediatri pratiğinde en sık hastaneye başvuru nedenlerinden birisidir. Bu çalışmada üçüncü basamak eğitim araştırma hastanesi çocuk nöroloji polikliniğine baş dönmesi şikâyetiyle konsülte edilen hastaların demografik özellikleri, ayırıcı tanısı, klinik ve laboratuvar bulguları ile değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntem: Konya Eğitim ve Araştırma Hastanesi çocuk nöroloji polikliniğine Mart 2018 - Şubat 2019 tarihleri arasında baş dönmesi şikayeti ile konsülte edilen 18 yaşından küçük 132 hastanın verilerini retrospektif olarak değerlendirdik.
Bulgular: Hastaların 83’ü kız, 49’u erkek (kız/erkek oranı:1,7)’di. Ortanca yaş 14’tü. En sık etiyolojik nedenler; ortostatik hipotansiyon (%55,3), psikojenik vertigo (%7,6), sinüzit/mastoidit/labirintit (%6,1), migren (%6,1) ve benign paroksismal vertigo (%6,1)’ydu. Baş dönmesine eşlik eden en sık şikayetler; baş ağrısı (%48,5), göz kararması (%40,9) ve senkoptu (%18,9). Hastaların %95'ine konsültasyon öncesi veya sonrası beyin manyetik rezonans görüntüleme yapılmıştı ve sadece %4,8'inde nörolojik hayatı tehdit eden durum saptandı. Olası yaşamı tehdit eden baş dönmesi nedenleri arasında; hidrosefali, serebral arteriyel enfarktüs ve kardiyojenik nedenler (aritmi ve koroner arter hastalığı) ikişer hastada tespit edildi. Hayatı tehdit eden nörojenik baş dönmesine sahip tüm hastalar ek nörolojik belirti veya bulgulara sahipti.
Sonuç: Baş dönmesi yakınması ile pediatrik nöroloji konsültasyonu sağlanan çocuklarda benign etiyolojik nedenler sıktır. Ancak ilişkili nörolojik ve kardiyolojik ek belirti ve bulguların varlığında, yaşamı tehdit eden durumların dışlanması ve gereksiz tetkikten kaçınılması gerekmektedir
Choroba psychiczna a świadek w procesie karnym (wybrane problemy na styku prawa i medycyny)
Authors: Jagiełło Dariusz 
Published: June 2020

The content of the article aims to outline the basic problems that can be seen at the intersection of law and medicine, and relating to people with mental illness.
In criminal proceedings there are a number of witnesses, including those affected by illness. It should not be forgotten that they are the same witnesses as those who do not manifest such conditions, but special care should be taken towards them mainly in terms of the credibility of the testimonies given, as well as their current psychophysical condition.
The testimony of mentally ill witnesses cannot be fully overlooked, but every situa-tion should always be analyzed in concreto. Extreme caution and insight must be exer-cised when considering the suitability of such evidence by a trial body, while respecting it within the limits of the free assessment of evidence.
As línguas da imprensa
Authors: Weber Andréa 
Published: June 2020

Este artigo lança um olhar sobre as línguas da imprensa brasileira registradas nos Anuários Estatísticos Brasileiros (AEBs) da primeira metade do século XX. Para tanto, analisamos 16 anuários estatísticos, no período entre 1908 e 1955, interpretando seus dados à luz das políticas linguísticas da época, bem como da relação da imprensa em Língua Estrangeira (LE) com as comunidades imigrantes e com o Estado. Os resultados indicam que o tema “línguas da imprensa” recebeu grande atenção no primeiro AEB (1908-1912), a qual diminuiu nas publicações posteriores até sua omissão durante o Estado Novo. Em termos estatísticos, por sua vez, a imprensa em LE correspondia a 5% do total nacional em 1912, ficando reduzida a menos de 1% nas décadas seguintes, na medida em que crescia a imprensa bilíngue no país. Ações de combate à imprensa em LE e de nacionalização dos imigrantes estão relacionadas a esses dados.