bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of bio-relevant dissolution method for prognosis of In-vivo performance of Dipyridamole from modified release capsules
Authors: Devi Thamizhanban  , Gampa Tulja Rani  , Kathiresan krishnasamy  
Published: May 2020

In-vitro biorelevant dissolution test method was developed for Dipyridamole in modified release multi-particulate dosage form, to simulate the product drug release after oral administration to human. The Dipyridamole concentration in blood plasma achieved after oral administration under pre-prandial (fasting) condition were used for deriving the target dissolution profile deconvoluting the plasma concentration using numerical deconvolution technique. The fraction of drug absorbed was considered as the target dissolution profile. The drug product was tested by using the dissolution method recommended by office of generic drugs, and the dissolution results observed are not comparable with the target dissolution profile. Dissolution method was developed using reciprocating cylinder, Bio-Dis (apparatus -3 as per USP), by simulating the pre-prandial conditions. A full factorial design of experiment was carried out to achieve the target dissolution profile. Media volume and dips per minute (DPM) are considered as main factors, in design of experiment. The dissolution results achieved with media volume 250ml and 10DPM were found to be comparable with target dissolution profile and observed with the F2 value (similarity factor) of 92%. The developed dissolution method demonstrates a very good in-vitro/in-vivo correlation under pre-prandial condition, and shall be used as a predictive in-vitro tool for evaluation Dipyridamole extended release capsules.
Kompetensi Bimbingan Karir Kolaboratif Konselor SMA Negeri di Kota Payakumbuh Sumatera Barat
Authors: Afdal Afdal 
Published: May 2020

<p>Keberhasilan pelaksanaan layanan bimbingan dan konseling di sekolah dipengaruhi oleh beberapa faktor, diantaranya adalah kualitas kolaborasi/kerjasama yang dilakukan oleh guru BK/konselor dengan orangtua. Permasalahannya sekarang adalah pelaksanaan kolaboratif/kerjasama dengan orang tua yang disusun dan terprogram dengan baik bukanlah menjadi bagian yang penting dalam pelaksanaan keseluruhan layanan bimbingan dan konseling oleh guru BK/konselor di sekolah. Untuk itu diperlukan pengukuran sejauh mana kompetensi bimbingan karir kolaboratif guru BK/konselor di SMA Negeri Kota Payakumbuh. Sampel dari penelitian ini adalah guru BK/konselor SMA Negeri di kota Payakumbuh yang berjumlah 19 orang yang diambil dengan metode <em>purposive random sampling</em>. Data dikumpulkan dengan menggunakan inventori kompetensi bimbingan karir kolaboratif yang dianalisis secara deskriptif.Hasil penelitian menunjukkan bahwa kompetensi bimbingan karir kolaboratif guru BK/konselor SMA Negeri di Kota Payakumbuh berada dalam kategori sedang. Pembahasan dan rekomendasi penelitian di bahas lebih lanjut.</p>
PERAN PANGKALAN PENDARATAN IKAN (PPI) CIKIDANG TERHADAP USAHA PERIKANAN DRIFT GILLNET
Authors: Syauqi Irfan , Muninggar Retno , Oktariza Wawan 
Published: May 2020

Peran Pangkalan Pendaratan Ikan (PPI) Cikidang telah diatur dalam Permen KP No 8 tahun 2012 tentang Kepelabuhanan Perikanan. Permasalahan penelitian adalah belum adanya informasi yang lengkap terkait peran PPI Cikidang terhadap usaha perikanan drift gillnet berdasarkan fungsi yang telah diatur dalam Permen KP No 8 ahun 2012. Disisi lain informasi terbaru terkait analisis usaha perikanan drift gillnet juga belum tersedia. Penelitian ini bertujuan untuk melakukan analisis peran PPI Cikidang terhadap usaha perikanan drift gillnet menggunakan pendekatan gap analysis dan melakukan analisis usaha perikanan drift gillnet. Penelitian menggunakan metode pengumpulan data purposive sampling dan simple random sampling. Hasil penelitian menunjukkan bahwa Peran PPI Cikidang terhadap kegiatan usaha perikanan drift gillnet berupa dukungan fasilitas pokok seperti breakwater dan dermaga sudah cukup baik, namun ada beberapa aspek yang masih belum sesuai dengan fungsi PP/PPI pada Permen KP No.08 tahun 2012, yaitu aspek transportasi hasil tangkapan, pendataan hasil tangkapan dan administrasi. Analisis usaha perikanan drift gillnet secara rata-rata memiliki keuntungan sebesar Rp21.720.045 per tahun, nilai R/C rata-rata sebesar 1,37, nilai pengembalian investasi sebesar 0,37 dan waktu pengembalian investasi mencapai 2 tahun 2 bulan.
Kata kunci: analisis usaha, drift gillnet, gap analysis, PPI Cikidang
Status of Animal Health and Role of Livestock Farming in Poverty Reduction in Balochistan, Pakistan
Authors: Mustafa Mohammad Zahid , Arif Hafiz Muhammad , Abdul Nasir  , Dad Muhammad Anwar  , Muhammad Din Mandokhail  , Muhammad Hashim  , Salahuddin Tareen  , Abdul Malik Kasi  
Published: May 2020

Balochistan is the largest province of Pakistan with almost 44% of the country land. Most of the area is rangeland and only 5-7 % area is hardly cultivable and more than 70% population depend upon livestock for their livelihood. Animal rearing is the centuries old occupation of farmers. The province produces 45% and 22% sheep and goat population of the country. Different diseases such as, Enterotoxaemia, sheep and goat Pox, Contagious Caprine Pleuropneumonia, Anthrax and Hemorrhagic Septicemia, Peste des Petits ruminants and Foot and Mouth disease are the most common infections of small and large ruminants. Vaccination covers hardly 10% of the population. The role of livestock in poverty reduction inevitable. Although animal health care facilities are available throughout the province but still it needs to be expanded and improved. Establishment of new Vaccine production centers in the province may be helpful to cover the vaccination of animals.
Expression of Cytoskeleton Actin in Cancer and Metastasis
Authors: Afzal Sabeera , Sadaf Hina , Fatima Qurat-ul-ain 
Published: May 2020

Cytoskeleton in Eukaryotic cell is very important for cell to keep the exact shape and supports the plasma membrane and give the mechanical support to cell. Actin is a type of cytoskeleton that is involved in several functions. Actin filaments are made up of indistinguishable actin binding proteins which is set in a lengthy curved chain which performs important function of body. Expresion of some actin binding proteins are regulated during carcinogenesis and metastasis, these proteins include Arp2/3 (Actin related protein 2 and 3 complex), fascin and the tropomyosinâ€™s, WASP/WAVE (Wiskott-Aldrich syndrome protein/WASP and Verprolin homologous protein) complexes. The expansion of cancer cells from the primary tumor to other tissues and the organs is called metastasis. The connection amongst the hyperactivated signaling pathways plays a very important role in the development of metastatic. GPCRs (G Protein Coupled Receptors) through Î²-arrs (Î²-arrestins) act as a intracellular signaling particles. In tumor cells the increased and decreased expression of these actin binding proteins are involved in progression of different types of cancer and metastasis.
For further insight we have to understand what is actin and the function of actin binding proteins.
The pattern of chicken production in the Quetta (Pakistan)
Authors: Hameed Tahir 
Published: May 2020

Abstract
The regression models were used for prediction of layer, broiler, egg and chicken meat production on the basis of last 20 years population; as well as wholesale price change for poultry products. The layer population at the commercial farms in Quetta shows a marked increase from 2001 (9.55 thousand birds) to 27.50 thousand birds in 2019; broiler production from 72.80 thousand birds in the year 2001 to 795 thousand birds in the year 2019; egg production from 201 thousand in the year 1991 to 5150 thousand in the year 2019; chicken meat production increased from 111772 metric tons in the year 1991 to 587000 metric tons in the year 2019.
Religious Tolerance, Freedom of Conscience, Freedom of Religion and Belief in the period of Establishment of Christianity
Authors: Babii Mykhailo 
Published: May 2020

The author examines the process of establishment of Christian understanding of freedom of conscience and freedom of religion and tolerance. In doing so, he draws on the achievements of the Greek and Greek-Roman traditions of interpreting freedom of conscience. The time of late antiquity accounts for the time of organizational establishment and strengthening of the new religion - Christianity. Describing this period, the author notes the presence of a variety of cults and sects in which foreign gods (in particular, Egyptian and Iranian) were worshiped. In this situation, individuals were free to choose their faith and satisfy their personal need for spiritual connection with God or gods. Against the background of the fall of the authority of ancient religions, the emergence and strengthening of the Emperor cult Christians seek recognition by the authorities, the equation of rights. After all, Christianity becomes a state religion. At this time, a new religious paradigm was emerging that could be a factor in the multi-ethnic, multi-tribal, or multilingual unity of the Roman Empire. The tendency of growing interest in monotheistic, in particular Jewish, religion became noticeable: the idea of one and all-pervading God was opposed to ancient polytheism.
The article reveals the peculiarities of the Christian understanding of freedom, which underlies the inner personal spiritual freedom bestowed by God. Christianity the first formulated the idea of freedom of religious conscience as freedom to choose religion. In addition to the individual dimension of freedom of conscience, Christianity has actualized the community's right to freedom of religion, freedom of outside religion, and worship. At the same time, it theoretically substantiated these rights and practically required its observance by the authorities.
The legitimacy of the affirmation of the principle of freedom of religious conscience is the Milan edict of 313, which opened the union of the Christian church and the state, as well as the constitutionalization of the Christian church as a state church. This provoked persecution on religious grounds and the struggle of different movements, both within Christianity and beyond, for the right to freedom of religion, the free expression of their religious beliefs.
Christianity significantly influenced the evolution of ideas about freedom of conscience, becoming the semantic nucleus of its modern understanding. However, early Christianity proved to be a force that, in the struggle for its claim, was repeatedly harassed, but also resorted to persecution of dissenters, showing intolerance to other worldviews and religions.
Pengaruh Ekstrak Bunga Kembang Sepatu (Hibiscus Rosa-Sinensis Linn.) terhadap Jumlah, Motilitas, Morfologi, Viabilitas Spermatozoa Tikus Jantan
Authors: Julia Dina , Salni Salni , Nita Sri 
Published: May 2020

Partisipasi laki-laki dalam KB masih relatif rendah bila dibandingkan dengan keikutsertaan perempuan. Salah satu tanaman obat tradisional yang digunakan adalah bunga kembang sepatu yang bersifat antifertilitas. Penelitian ini bertujuan untuk menguji pengaruh ekstrak bunga kembang sepatu terhadap jumlah, motilitas, morfologi dan viabilitas spermatozoa tikus jantan (Rattus norvegicus). Penelitian ini merupakan penelitian eksperimental dengan menggunakan Rancangan Acak Lengkap (RAL). Sampel dalam penelitian ini menggunakan 25 tikus jantan strain Sprague Dawley usia 60-70 hari dengan berat badan 200-210 gram. Lama perlakuan 30 hari dengan dosis 200 mg/kgBB, 300 mg/kgBB, 400 mg/kgBB. Data disajikan dalam bentuk tabel dan diagram serta narasi untuk menginterpretasikan data tersebut. Hasil penelitian ini menunjukkan adanya penurunan jumlah sperma pada kelompok perlakuan dibanding kelompok kontrol (p=0,000), terjadi penurunan motilitas sperma (p=0,001), terjadi peningkatan morfologi abnormal (p=0,000), dan terjadi penurunan viabilitas spermatozoa antara kelompok perlakuan dibanding kelompok kontrol (p=0,000). Dapat disimpulkan bahwa ada perbedaan bermakna dari pengaruh ekstrak bunga kembang sepatu terhadap jumlah, motilitas, morfologi, viabilitas spermatozoa.
Efektivitas Ekstrak Etanol Daun Salam (Eugenia polyantha) terhadap GLUT 4 di Jaringan Adiposa dan Kadar Gula Darah Puasa pada Tikus Putih Jantan
Authors: Zanaria Rima , Kamaluddin MT , Theodorus Theodorus 
Published: May 2020

Diabetes Mellitus merupakan penyakit epidemik global, cenderung meningkat dengan berbagai kondisi patologis yang menyertainya, sehingga membutuhkan preparat baru yang poten,tidak toksik, efektif dalam pemberian dan harga terjangkau untuk mengevaluasi efektivitas ekstrak etanol dalam daun salam (Eugenia polyantha) terhadap GLUT 4 di jaringan adiposa dan kadar gula darah puasa tikus putih jantan galur wistar (Rattus norvegicus) yang diinduksi diet tinggi lemak (HFD-dexamethasone. Desain penelitian ini adalah ekperimental, rancangan pre dan post test dengan kelompok kontrol dilakukan di Animal house Fakultas Kedokteran Universitas Sriwijaya. Tiga puluh enam ekor tikus dengan berat antara 150 - 200 gram secara acak dibagi menjadi 6 kelompok. Setelah di aklimatisasi selama 7 hari dan diinduksi dengan high fat diet 5 ml per oral serta dexamethasone 250 µg/kgbb intraperitoneal selama 35 hari. Kelompok kontrol (-) diberi larutan aquades sebanyak 2 ml, kelompok pertama diberi ekstrak ethanol daun salam dosis 62,5 per kilogram berat badan, kelompok kedua diberi ekstrak ethanol daun salam dosis 125 mg per kilogram berat badan, kelompok ketiga diberi ekstrak etanol daun salam dosis 250 mg per kilogram berat badan, kontrol (+) diberi Pioglithazone dosis 0,02 gram per kilogram berat badan. Semua perlakuan diberikan selama 14 hari. Data diperoleh dengan analisis ANOVA dan post hoct test spss versi 18. Induksi HFD /dexamethasone pada tikus selama 35 hari menujukan peningkatan kadar glukosa darah secara signifikan lalu tikus dieutanasia dengan ketamin 70 mg/kgbb intraperitoneal lalu dilakukan autopsi dan diambil jaringan adiposa. Intervensi ekstrak ethanol daun salam selama 14 hari pada tikus diabetes mellitus efektif meningkatkan kadar GLUT 4 di jaringan adiposa (p<0,05) dibanding kontrol negatif dan Pioglitazone, Ekstrak etanol daun salam dosis 125 mg per kilogram berat badan tikus merupakan dosis paling efektif dalam meningkatkan GLUT 4 dijaringan adiposa, sedangkan dalam menurunkan kadar gula darah puasa dosis 62,5 mg/kgbb tikus, 125 mg/kgbb tikus,250 mg/kgbb tikus sama efektifnya dengan kontrol positif obat pioglithazone. Ekstrak etanol daun salam (Eugenia polyantha) berpotensi meningkatkan kadar GLUT 4 di jaringan adiposa tikus dan menurunkan kadar gula darah puasa pada tikus putih jantan (Rattus norvegicus) galur wistar yang diinduksi HFD/dexametasone. Kata kunci : Ektrak Etanol daun salam, HFD/Dexamethasone, GLUT 4 di jaringan adiposa, in Vivo
Species composition and methicillin resistance of staphylococci taken on dairy farms
Authors: Horiuk Y. V. , Kukhtyn M. D. , Salata V. Z. , Horiuk V. V. 
Published: May 2020

Methicillin-resistant staphylococci can often asymptomatically colonize animals and humans and are capable of causing disease in them. Therefore, their identification and species identification are important for establishing the source of zoonotic infection and the reservoirs of antimicrobial resistance genes. The purpose of the search was to study the spread of methicillin-resistant staphylococci on dairy farms in the Western region of Ukraine. BD Baird-Parker Agar (HiMedia, India) was used to isolate staphylococci. Specific identification of pure cultures was performed using “RapID Staph Plus” kits (Oxord, UK). Staphylococcus sensitivity to methicillin was determined by inoculum application on Muller-Hinton agar with oxacillin (HiMedia, India). The sensitivity of the isolates to antibacterial preparations was determined by disco-diffusion method. The results of our searches show that Staphylococcus aureus is virtually identical in the amount both from cows (50.1 %) and from humans (62.4 %). In this case the frequency of its isolation among other species was 20.3 %. Along with Staphylococcus aureus there are such species as: S. haemolyticus (20.3 %), S. saprophyticus (13.6 %), S. xylosus (14.0 %), S. chromogenes (11.1 %), S. sciuri (8.8 %), S. epidermidis (4.8 %), S. hominis (3.4 %), S. cohnii (2.6 %) and S. warner (0.7 %). In this case, approximately the same irradiation of cows, humans and the environment by species S. haemolyticus (44.5:70.8:58.8 %), S. epidermidis (12.7:16.6:9.1 %), S. xylosus (26.0:37.4:52.9 %) is observed. The share of S. aureus strains on methicillin-resistant dairy farms in the Western Ukraine is 26.8 %. The proportion of S. aureus strains on methicillin-resistant dairy farms in the Western Ukraine is 26.8 %. Methicillin resistance is also shown S. haemolyticus, S. saprophyticus, S. xylosus та S. chromogenes. In this case their number is 1.1, 1.3, 1.6 and 5.5 times lower, respectively, and S. hominis 1.2 times higher than S. aureus. In addition, the selected cultures simultaneously show resistance to two or more antibiotics. Thus, staphylococci circulating on dairy farms are a large reservoir of resistance genes of antimicrobial preparations. Therefore, it is necessary to establish a constant control of the secretion of staphylococci resistant to β-lactam antibiotics.
Akhlak Tasawuf Basis Pendidikan Multikultural Di Indonesia
Authors: Rajab Hadarah Rajab 
Published: May 2020

Penelitian ini bertujuan untuk mendeskripsikan bagaimana sikap aklah yang diajarkam ilmu tasawuf dapat menjadi landasan Pendidikan multicultural. Metode yang digunakan adalah dengan metode penelitian kualitatif fenomenologis, dengan melalui pendekatan wawancara mendalam dan pengamatan langsung di lapangan, serta observasi. Adapaun hasil dari pene;itian ini adalah desain Pendidikan Multikultural yang berbasis Akhlak Tasawuf. Kolaborasi antara konsep pendidikan multicultural di satu sisi dan perilaku sufi pada ajaran tasawuf dilain sisi. Pada dasarnya kedua unsur tersebut sudah berjalan dengan waktu yang cukup panjang dan telah merimplikasi ke berbagai aspek[1], namun pada bagian ini menawarkan kolaborasi kedua unsur dalam sistim pendidikan multikulturak berdimensi sufi[2] yang dimungkinkan menjadi suatu pola baru yang lebih teduh dan menciptakan kedamaian untuk bangsa Indonesia
This study aims to describe how the attitude that is taught by Sufism can be the basis of multicultural education. The method used is phenomenological qualitative research methods, through in-depth interviews and direct observation in the field, as well as observation. The results of this study are the design of Multicultural Education based on Moral Tasawuf. Collaboration between the concept of multicultural education on the one hand and Sufi behavior on Sufism on the other hand. Basically these two elements have been running for quite a long time and have been implicated in various aspects, but this section offers collaboration between the two elements in a multicultural education system with a Sufi dimension which is possible to become a new pattern that is more shady and creates peace for the Indonesian people

[1] Hadarah and Gani, ‘The Implementation of Tarekat Naqsyabandiyah’s Sufism Values in South Celebes’.
[2] Enok Rohayati, ‘Pemikiran al-Ghazali tentang Pendidikan Akhlak’, Ta’dib: Journal of Islamic Education (Jurnal Pendidikan Islam), vol. 16, no. 01 (2011), pp. 93–112.
Analisis Pusat Pelayanan Kegiatan Minapolitan
Authors: Sari Dewi Purnama 
Published: May 2020

Tabalong Regency based on Regional spatial Plan (RTRW) of South Kalimantan Regency 2014-2034 has the potential to be developed into a Minapolitan region. In principle, Minapolitan is a fishery program that seeks to synergize the production of raw materials, processing and marketing in a series of major activities in one area or region with the concept of involving the entire community in It. With the increase in the population of Tabalong Regency, it makes the need to increase the facilities available in the area as a factor in driving service and activities of fisheries by looking at the area that is the center of growth For the area that has a level of facilities that have a lack of the hierarchy in each district by conducting a system analysis of service center with the results of which 12 sub-districts that have the Minapolitan activities of Tanjung District become The centre of Minapolitan activities with Murung Pudak Sub-district became its sub-center of activities. With other sub-districts as a supporting area of Minapolitan activities.
Keyword: Marketing, Minapolitan, Production
Kajian Beban Emisi Pencemar Udara (NOx, CO, HC, PM10, SO2, CO2) Sektor Transportasi Darat Di Lingkungan Institut Teknologi Kalimantan Berdasarkan Jam Sibuk Dengan Metode Tier 2
Authors: Rahendaputri Chandra Suryani , Maria Madah , Fausia Rizkina Nurul 
Published: May 2020

Kajian beban emisi telah dilaksanakan di lingkungan Institut Teknologi Kalimantan (ITK) dalam kurun waktu satu hari. Perhitungan beban emisi CO, NOx, PM10, SO2, HC dihitung menggunakan metode TIER 2, yaitu dengan cara menghitung perjalanan rerata kendaraan, atau Vehicle Kilometer Traveled (VKT) dan kemudian dikalikan dengan faktor emisi masing-masing jenis pencemar untuk tiap jenis kendaraan berbeda. Sedangkan untuk pencemar CO2 menggunakan metode perhitungan jumlah konsumsi bahan bakar dikalikan dengan faktor emisi. Setelah perhitungan didapatkan bahwa jenis kendaraan yang mendominasi adalah sepeda motor. Emisi terbesar terjadi pada pukul 09.30-10.30 yaitu pada jam peralihan perkuliahan sesi 1 dan sesi 2, yang dapat diidentifikasi sebagai jam sibuk. Emisi pencemar terbesar adalah CO2 yaitu sebesar 248.31 Kg/hari diikuti oleh CO sebesar 41.53 Kg/hari. Pencemar udara yang paling sedikit diemisikan adalah SO2 yaitu hanya sebesar 0.028 Kg/hari. Pencemar lainnya yaitu NOx sebesar 0.986 Kg/hari dan PM10 sebesar 0.656 Kg/hari. Dominasi emisi sepeda motor terlihat jelas pada pencemar CO, HC dan CO2, sedangkan pada pencemar lainnya, mobil bensin maupun solar juga berperan dalam mengemisikan pencemar tersebut.
O Curso De Matemática Da Faculdade De Filosofia, Ciências E Letras De Belém (1955-1957)
Authors: Rodrigues dos Santos Janes Kened , Alencar Alves José Jerônimo de 
Published: May 2020

Este artigo, de viés historiográfico, tem como objetivo analisar as condições que possibilitaram a implantação do Curso de Bacharelado em Matemática da Faculdade de Filosofia, Ciências e Letras, situada em Belém do Pará. Pretendemos mostrar as características diferenciadas dessa instituição de ensino, o contexto de implantação na localidade que não tinha o ensino de nível superior especializado em áreas de conhecimento favorecendo à formação de professores, os fatores que contribuíram para o Curso de Matemática fazer parte do contexto social educacional. Concluímos que uma das principais características do Curso em questão foram os conteúdos dos assuntos ensinados serem centrados na Matemática ou Física, essa última ocupava um espaço significativo no currículo. Quanto às condições que o possibilitaram à Criação do Curso, elas foram favorecidas pela existência de uma elite letrada local que contribuiu para o início e funcionamento das atividades de ensino da Faculdade. Além disso, havia a valorização e difusão dos saberes dessas áreas de conhecimento na cultura local, evidenciado no currículo dos cursos superiores nos quais os docentes do Curso de Matemática foram formados e na atuação deles como professores das matérias de física e de matemática nas escolas secundárias localizadas em Belém.