bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying Opportunities and Challenges for Patients With Sarcoma as a Result of Comprehensive Genomic Profiling of Sarcoma Specimens
Authors: Hay Margaret A. , Severson Eric A. , Miller Vincent A. , Liebner David A. , Vergilio Jo-Anne , Millis Sherri Z. , Chen James L. 
Published: March 2020

PURPOSEComprehensive genomic profiling (CGP) of sarcomas is rapidly being integrated into routine clinical care to help refine diagnosis and prognosis and determine treatment. However, little is known about barriers to successful CGP or its clinical utility in sarcoma. We set out to determine whether CGP alters physician treatment decision-making, and whether sarcoma subtypes influence the frequency of successful technical performance of CGP.METHODSA single-institution study evaluated profiling outcomes of 392 samples from patients with sarcoma, using a commercially available CGP panel. Of this group, 34 patients were evaluated prospectively (Decision Impact Trial) to evaluate the utility of CGP in physician decision-making. All cases were retrospectively analyzed to identify causes of CGP failure.RESULTSCGP successfully interrogated 75.3% (n = 295 of 392) of patients with sarcoma. Bone sarcomas had lower passing rates at 65.3% (n = 32 of 49) compared with soft tissue sarcomas at 76.7% (n = 263 of 343; P = .0008). Biopsy location also correlated with profiling efficiency. Bone biopsy specimens had a 52.8% (n = 19 of 36) passing rate versus lung (61.1%; n = 33 of 54) and abdomen (80.1%; n = 109 of 136) specimens. CGP altered physician treatment selection in 25% of evaluable patients (n = 7 of 28) and was associated with improved progression-free survival.CONCLUSIONTo our knowledge, this is the largest technical evaluation of the performance of CGP in sarcoma. CGP was effectively performed in the vast majority of sarcoma samples and altered physician treatment selection. Tumor location and tissue subtype were key determinants of profiling success and associated with preanalytic variables that affect DNA and RNA quality. These results support standardized biopsy collection protocols to improve profiling outcomes.
Hard Road to Heaven: Bearing the Weight of Soul Judgment in Korea’s First Bible Commentary
Authors: Torrey Deberniere Janet 
Published: March 2020

AbstractKorea’s first Bible commentary, Direct Exposition of the Bible for Widespread Benefit (Syŏnggyŏng chikhae kwangik), is marked by a strong emphasis on human guilt and eternal judgment in its extensive didactic explication. How might this seemingly pessimistic message, read widely by Korean Catholics during the nineteenth century, support conversion in spite of the burden it imposes? This article explores the theme of soul judgment in Direct Exposition against the background of preexisting Korean cultural paradigms. It shows that this teaching carried a logic that could be compelling to Chosŏn Catholics, and that the psychological burdens such threats of judgment in the afterlife might impose could be mitigated by promises of help featured in the same text. This analysis also concludes that, in the political and social situation of nineteenth-century Korea, the emphasis on soul judgment offered validation of suffering and control over destiny.
Japan’s Education Policies in Korea in the 1910s: “Thankful and Obedient”
Authors: Hall Andrew 
Published: March 2020

Abstract
In the 1910s, Japanese colonial officials worked to legitimize their recently acquired rule of Korea by providing public elementary education, gradually expanding from an initially limited offering. Their public schools existed in tension with Korean-run private schools, which the Japanese barely tolerated. There was also a tension within the Japanese camp over the proper curriculum for the public elementary schools. The Korean Education Ordinance of August 1911 was a compromise between Japanese officials in Korea, who generally favored a gradual approach to colonial rule, and Japanese educators and officials in Japan, who generally were optimistic about Japan’s ability to assimilate the Koreans through education. This article expands our understanding of the process of drafting the ordinance. It examines the Japanese “national language” and “Korean and literary Sinitic” textbooks published during the 1910s, and finds that the compromise resulted in messages of thankfulness and obedience, stressing Japanese superiority and Korean backwardness. Finally, it reviews the Japanese attempts to control Korean-run private schools. This article explicates the creation and implementation of colonial education policy by examining internal and external documents published by the Government-General of Korea and its employees, the textbooks the government published, and Japanese education journals.
SUMOylation in development and neurodegeneration
Authors: Yau Tak-Yu , Molina Oscar , Courey Albert J. 
Published: March 2020

ABSTRACT
In essentially all eukaryotes, proteins can be modified by the attachment of small ubiquitin-related modifier (SUMO) proteins to lysine side chains to produce branched proteins. This process of ‘SUMOylation’ plays essential roles in plant and animal development by altering protein function in spatially and temporally controlled ways. In this Primer, we explain the process of SUMOylation and summarize how SUMOylation regulates a number of signal transduction pathways. Next, we discuss multiple roles of SUMOylation in the epigenetic control of transcription. In addition, we evaluate the role of SUMOylation in the etiology of neurodegenerative disorders, focusing on Parkinson's disease and cerebral ischemia. Finally, we discuss the possibility that SUMOylation may stimulate survival and neurogenesis of neuronal stem cells.
mRBPome capture identifies the RNA-binding protein TRIM71, an essential regulator of spermatogonial differentiation
Authors: Du Guihua , Wang Xinrui , Luo Mengcheng , Xu Weiya , Zhou Tao , Wang Mei , Yu Luping , Li Lufan , Cai Li'e , Wang P. Jeremy , Zhong Li John , Oatley Jon M. , Wu Xin 
Published: March 2020

ABSTRACT
Continual spermatogenesis relies on the actions of an undifferentiated spermatogonial population that is composed of stem cells and progenitors. Here, using mouse models, we explored the role of RNA-binding proteins (RBPs) in regulation of the biological activities of this population. Proteins bound to polyadenylated RNAs in primary cultures of undifferentiated spermatogonia were captured with oligo (dT)-conjugated beads after UV-crosslinking and profiled by proteomics (termed mRBPome capture), yielding a putative repertoire of 473 RBPs. From this database, the RBP TRIM71 was identified and found to be expressed by stem and progenitor spermatogonia in prepubertal and adult mouse testes. Tissue-specific deletion of TRIM71 in the male germline led to reduction of the undifferentiated spermatogonial population and a block in transition to the differentiating state. Collectively, these findings demonstrate a key role of the RBP system in regulation of the spermatogenic lineage and may provide clues about the influence of RBPs on the biology of progenitor cell populations in other lineages.
Determinants of contraceptive use among married women in Indonesia
Authors: Gafar Alfian , Suza Dewi Elizadiani , Efendi Ferry , Has Eka Mishbahatul Mar’ah , Pramono Ahmad Putro , Susanti Ika Adelia 
Published: March 2020

Background: Contraceptives in family planning are used to control the timings between pregnancies. Although the number of those using family planning has increased, determinants of contraceptive use among married women in Indonesia remain insufficient. This research aimed to identify the factors associated with contraceptive use among married women in Indonesia. Methods: This study employed data from the Indonesian Demographic and Health Survey 2017. We selected 35,621 married women aged 15–49 years. Then, the determinants of contraceptive use among married women in Indonesia were examined by binary logistic regression. Results: Women’s age (Adjusted Odds Ratio (AOR)=0.529; 95% CI=0.470–0.597), the number of living children (AOR=44.024; 95% CI=33.193–58.390), education level (adjusted odds ratio=2.800; 95% CI=2.181–3.594), wealth index (AOR=1.104; 95% CI=0.978–1.246), frequency of watching television (AOR=1.555; 95% CI=1.321–1.829), and frequency of using the Internet (AOR=0.856; 95% CI=0.794–0.924) were significantly associated with contraceptive use among married women. Conclusions: This study highlights the determinants of contraceptive use among married women in Indonesia. Women’s age, the number of living children, education level, wealth index, and access to information may influence contraceptive use among these women. This study emphasizes that health education and promotion on the importance of using contraception should be initiated in innovative ways.
LA VISTA PUESTA EN ABISMO. JOHANN HEINRICH FÜSSLI, TRADUCTOR VISUAL
Authors: Arnaldo Javier 
Published: March 2020

En el concepto de traducción “mítica”, acuñado por Novalis, aparece la instancia a una significativa “elevación estilística” en la práctica de la traducción. Según ese paradigma, la traducción aporta instrumentos eficientes de autocreación a la lengua que en ella se renueva. El trabajo artístico de Johann Heinrich Füssli, tan estrechamente ligado a la traducción visual de modelos literarios, no se basta con el entendimiento de la traducción como equivalente o espejo de un original; antes bien, coloca la traducción como reflejo puesto en abismo para la vista por un continuum creado. Un ideal infinitamente reflexivo reclama que la traducción proyecte sus actos como lo hace la vista en un enfrentamiento entre espejos. In the concept of 'mythical translation', coined by Novalis, there is a significant emergence of 'stylistic elevation' in the practice of translations. According to this paradigm, translations give efficient instruments of self-creation to the language that is renewed. The artistic work of Henry Fuseli, tightly linked to visual translation of literary models, does not conform to the understanding of translation as the equivalent or mirror of an original; on the contrary, it lays translation as a reflection placed in an abyss for the sight by a created continuum. An ideal infinitely reflective calls for translation to project its acts like the sight does when mirrors are facing each other.
Determination of 1-propanol, ethanol, and methanol concentrations in water based on a one-dimensional phoxonic crystal sensor
Authors: Shaban Samar M. , Mehaney Ahmed , Aly Arafa H. 
Published: March 2020

In this research, the photonic and phononic response of one-dimensional multilayer phoxonic crystals (PxCs) with normal incident of electromagnetic and acoustic waves is discussed. The presented design can work as a highly sensitive sensor for measuring three binary alcohol/water mixtures (i.e., 1-propanol/water, ethanol/water, and methanol/water) for a wide range of concentrations. The PxC sensor is able to detect small changes in the refractive index and longitudinal sound velocity of the alcohol/water mixture with initially neglecting the acousto-optical interaction. The sensor design is a defective structure as [

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Tropical Curves and Covers and Their Moduli Spaces
Authors: Markwig Hannah 
Published: March 2020

AbstractTropical geometry can be viewed as an efficient combinatorial tool to study degenerations in algebraic geometry. Abstract tropical curves are essentially metric graphs, and covers of tropical curves maps between metric graphs satisfying certain conditions. In this short survey, we offer an introduction to the combinatorial theory of abstract tropical curves and covers of curves, and their moduli spaces, and we showcase three results demonstrating how this theory can be applied in algebraic geometry.
From a cross-cultural research to a film cross-analysis of Italian and American cultural generalizations and stereotypes: My Name is Tanino and Under the Tuscan Sun
Authors: Ciofalo Giovanni 
Published: March 2020

AbstractThis article develops from a wider inter-university research project that focused on the analysis of reciprocal forms of representation of United States and Italy within media industries, and proposes a cross-analysis of the filmsMy Name is Taninodirected by andUnder the Tuscan Sunby . The aim is to highlight how both films refer to cultural generalizations and stereotypes in regards to American and Italian cultures in a complementary way. To identify the recurring elements of the communicative frame, the article takes an approach based on the recognition ofhigh-contextandlow-contextstyles. Finally, to deepen the films’ shared logic of intercultural representation, this article proposes a further interpretative approach based on the Developmental Model of Intercultural Sensitivity (DMIS) (), useful in categorizing recurrent attitudes towards cultural differences such asdenial, minimization, defence, acceptance, integrationandadaptation.
Autoimmune Hepatitis Associated With Turmeric Consumption
Authors: Lee Brian S. , Bhatia Taruna , Chaya Charles T. , Wen Robert , Taira Mark T. , Lim Brian S. 
Published: March 2020

ABSTRACT
Turmeric is a popular herbal dietary supplement that has been considered safe and even shown to have hepatoprotective properties. In the recent times, however, there have been a few case reports of turmeric-induced liver injury. We report a 55-year-old woman with chronic turmeric consumption whose initial diagnosis was acute autoimmune hepatitis. She declined steroid treatment, and hence, we recommended discontinuing her long-term turmeric usage. A month after discontinuation, her liver function returned to normal. This case demonstrates the importance of recognizing the potential adverse effects of herbal dietary supplement.
Overcoming the Challenge of Full-Thickness Resection of Gastric Lesions Using a Colonic Full-Thickness Resection Device
Authors: Fahmawi Yazan , Krutika Patel , Kumar Manoj , Merritt Lindsey , Mizrahi Meir 
Published: March 2020

ABSTRACT
Endoscopic full-thickness resection device (FTRD) is a new and promising device for endoscopic full-thickness resection of gastrointestinal lesions. Limited data is available regarding its role in endoscopic full-thickness resection of upper gastrointestinal lesions compared with its well-studied role in colorectal lesions. Colonic FTRD is a preloaded device with a large cap which limits peroral insertion. A 49-year-old woman was referred to us for submucosal gastric lesion resection. Gradual dilatation of the upper esophagus was performed before successful advancement of the endoscope mounted with a FTRD system into the stomach. The lesion was successfully resected with no complications.
Hepatitis E Infection With Acute Liver Failure
Authors: Phan Timothy , Desmond Christopher 
Published: March 2020

ABSTRACT
A 21-year-old man from India presented with acute hepatitis associated with a 1-week history of abdominal pain, pruritus, and dark urine. Over a 7-day admission, the patient's acute hepatitis evolved into acute liver failure with low-grade encephalopathy, markedly elevated transaminases, bilirubin, and impaired hepatic synthetic function. He was eventually diagnosed with acute hepatitis E virus (HEV) and was transitioned to supportive management. Acute HEV is a rare cause of acute liver failure. Hence, this case highlights the importance of early consideration of HEV in all patients with acute hepatitis who have originated from endemic regions.
Impact of implementing a category 1 external quality assurance scheme for monitoring harmonization of clinical laboratories in Spain
Authors: Ricós Carmen , Fernández-Calle Pilar , Marqués Fernando , Minchinela Joana , Salas Ángel , Martínez-Bru Cecília , Boned Beatriz , Gómez-Rioja Rubén , Cortés Marià , González-Lao Elisabet , García-Lario JV , Tejedor-Ganduxé Xavier , Bullich Sandra , Ventura Montse , Simón Margarida , Vilaplana Carlos , González-Tarancón Ricardo , Fernández-Fernández Mª Pilar , Ramón-Bauzá Francisco , Corte Zoraida , Llopis Mª Antonia , Díaz-Garzón Jorge , Perich Carmen 
Published: March 2020

Abstract

Background
The objective of the present study was to examine the evolution of the analytical performance specifications (APS) used in External Quality Assurance (EQA) schemes, as well as the efficacy of a category 1 EQA scheme in monitoring the harmonization of clinical laboratory results in Spain.

Methods
A review of the literature on the types of quality specifications used in schemes in other countries and their evolution was performed. In addition, a comparative analysis of the potential impact that different APS from eight countries had on clinical decision-making was made based on three measurands: sodium, thyroid-stimulating hormone (TSH), and activated partial thromboplastin time (aPTT).

Results
Harmonization of analytical methods was demonstrated by assessing whether average results deviated from the certified reference value of control materials within the APS derived from biological variation (BV). The APS used in EQA have evolved from state-of-the-art models to BV. Poor clinical decision-making would occur if the results accepted by some APS were applied.

Conclusions
In Spain, only 2 of the 18 measurands studied are considered to be well harmonized. Closer collaboration between laboratories and analytical system providers would be required to resolve discrepancies.
Suggesting teaching methods by analyzing the behavior of children with special needs
Authors: Shrawankar Urmila , Shireen Azra 
Published: March 2020

Abstract
The behavioral pattern of children with special needs depends on their emotional and developmental disability. Any abnormal and incorrect pattern of behavior which is below the level of development as the expected norm can be considered as “the challenging behavior.” For supporting children with behavioral problems, many interventions and strategies alone, or in combination, are used. Behavioral and developmental problems, if not treated well, in childhood, may cause a problem and have negative long-term and short-term effects on a child’s personal life, education, family, and professional life. Detailed knowledge about the child’s behavior is important to define the problem. Hence, the software contains the questionnaire pattern, which is divided into categories like parents, teachers, doctors, and friends. Child behavior checklist is used to define the questionnaire. Images and video analysis are used to detect the current emotion in the child. By analyzing the behavioral pattern and current emotion, the teaching method will be suggested.
Acute toxicity of cyanide in aerobic respiration: Theoretical and experimental support for murburn explanation
Authors: Manoj Kelath Murali , Ramasamy Surjith , Parashar Abhinav , Gideon Daniel Andrew , Soman Vidhu , Jacob Vivian David , Pakshirajan Kannan 
Published: March 2020

AbstractThe inefficiency of cyanide/HCN (CN) binding with heme proteins (under physiological regimes) is demonstrated with an assessment of thermodynamics, kinetics, and inhibition constants. The acute onset of toxicity and CN’s mg/Kg LD50(μM lethal concentration) suggests that the classical hemeFe binding-based inhibition rationale is untenable to account for the toxicity of CN. In vitro mechanistic probing of CN-mediated inhibition of hemeFe reductionist systems was explored as a murburn model for mitochondrial oxidative phosphorylation (mOxPhos). The effect of CN in haloperoxidase catalyzed chlorine moiety transfer to small organics was considered as an analogous probe for phosphate group transfer in mOxPhos. Similarly, inclusion of CN in peroxidase-catalase mediated one-electron oxidation of small organics was used to explore electron transfer outcomes in mOxPhos, leading to water formation. The free energy correlations from a Hammett study and IC50/Hill slopes analyses and comparison with ligands$\left( {\text{CO}}/{{{{\text{H}}_{2}}\text{S}}/{\text{N}_{3}^{\text{-}}}\;}\; \right)$provide insights into the involvement of diffusible radicals and proton-equilibriums, explaining analogous outcomes in mOxPhos chemistry. Further, we demonstrate that superoxide (diffusible reactive oxygen species, DROS) enables in vitro ATP synthesis from ADP+phosphate, and show that this reaction is inhibited by CN. Therefore, practically instantaneous CN ion-radical interactions with DROS in matrix catalytically disrupt mOxPhos, explaining the acute lethal effect of CN.
Effect of Box Height on Box Jump Performance in Elite Female Handball Players
Authors: Koefoed Nikolaj , Dam Sebastian , Kersting Uwe Gustav 
Published: March 2020

Abstract
Koefoed, N, Dam, S, and Kersting, UG. Effect of box height on box jump performance in elite female team handball players. J Strength Cond Res 36(2): 508–512, 2022—This study aimed at investigating whether a link exists between performance in a countermovement jump and the height of the box an athlete could successfully jump onto. Furthermore, it was investigated whether the height of the box influences the takeoff. Ten, elite, female team, handball players were recruited for the study (age: 20.9 ± 3.2 years; height: 174.7 ± 7.6 cm; mass: 73.8 ± 6.7 kg). Subjects performed 3 maximal countermovement jumps. Subsequently, subjects jumped onto boxes of increasing height until they could no longer successfully jump onto the box. Subjects then performed 3 box jumps with maximal intention to boxes corresponding to 70% of their maximal center of mass displacement (LOW) and 90% of their maximal achieved box height (HIGH). Finally, subjects completed another 3 maximal countermovement jumps. There was no relationship between the maximal center of mass displacement in countermovement jumps and the maximal achievable box jump height (r
2 = 0.35; p = 0.071). Between jumps to LOW and HIGH boxes, there were no differences in the chosen variables, peak force (−156 ± 390 N; p = 0.239), peak power (25 ± 236 W; p = 0.747), peak center of mass displacement (0.003 ± 0.039 m; p = 0.840), peak rate of force development (−3.055 ± 6264 N·s−1; p = 0.157), and concentric time to takeoff (0.005 ± 0.044 seconds; p = 0.721). Because no differences could be found, the added risk of failure leading to injury and the limited possibilities of improving specific landing technique with low impact when jumping to high boxes in training cannot be justified.