bluuebunny/crossref_metadata_2025_split huggingface dataset:
Build Orientation Effect on Geometric Performance of Curved-Surface 316L Stainless Steel Parts Fabricated by Selective Laser Melting
Authors: Zhou Yue , Ning Fuda 
Published: June 2020

Abstract
Selective laser melting (SLM) is a powder bed fusion additive manufacturing technology that allows the production of high-performance metal parts with geometrically complex shapes, such as curved surface, can be used in practical engineering applications. In recent years, systematic attempts have been made to uncover the material-process-microstructure-property linkage in SLM-fabricated planar-surface metal parts; however, little is known on the performance and quality of SLM-fabricated metal parts with curved surfaces. In this paper, we studied the effects of build orientation on the geometric performance of SLM-built 316L stainless steel (SS) samples with a sinusoidal curved surface. The results indicated that the average values of profile roughness Ra and surface texture attributes Sa, Sk, and Vmc decreased with the increase in build orientation. Moreover, the locations at curvatures C2 and C4 exhibited the best surface finish at the build orientation of 75 deg and 90 deg. In addition, the least square method was used to fit the actual profile of the curved surface of as-built samples fabricated at each build orientation, and it was found the actual profile demonstrated the best consistency with the designed one at 90 deg build orientation. In this paper, the process–curvature–geometric performance relationship of SLM-built metal parts with curved surface was uncovered. In addition, this paper provides keen insights into assessing the geometric performance of SLM-built curved-surface metal parts and establishes a roadmap toward SLM-fabrication of metal parts with complex geometries for practical engineering applications.
Heat Transfer in Supercritical Steam Flowing Through Spiral Tubes
Authors: Kanungo Deepak Kumar , Shrivastava Sachin Kumar , Singh Nand Kumar , Sahu Kirti Chandra 
Published: June 2020

Abstract
We investigate heat transfer in supercritical steam flowing in a spiral tube by conducting three-dimensional numerical simulations. The current numerical solver has been validated with the existing experimental results, and simulations are performed by varying different geometric parameters of a spiral tube. The flow dynamics and heat transfer in a spiral tube are compared against those in a straight tube. For the parameters range considered in the present study, it is found that the heat transfer coefficient (HTC) in the spiral tube is 29% higher than that in the case of a straight tube for the same flow and thermal conditions. Our results indicate that the tangential velocity component resulting due to the spiraling effect of the steam is the primary reason for the enhancement of the HTC value. It is observed that while the HTC in a spiral tube is inversely related to the spiral diameter, it does not exhibit a strong relationship with the spiral pitch. Moreover, three existing heat transfer correlations are evaluated under the spiral flow condition and it is observed that none of them can calculate the HTC value accurately in spiral tubes. Using the Buckingham π-theorem, three modified correlations are proposed for the low, moderate, and high heat flux regimes, which accurately predict the wall temperature and HTC of supercritical steam in spiral tubes in all the heat flux regimes. The correlations have an error band of less than ±20%.
Experimental and Numerical Study of Chord-Wise Eight-Passage Serpentine Cooling Design for Eliminating the Coriolis Force Adverse Effect on Heat Transfer
Authors: Singh Prashant , Sarja Ajay , Ekkad Srinath V. 
Published: June 2020

Abstract
Gas turbine blades are equipped with internal cooling channels which are connected by 180 deg bends. Due to combined effects of Coriolis force and centrifugal buoyancy force, the heat transfer increases on the trailing side (pressure side) and decreases on the leading side (suction side) for radially outward flow. The trend in heat transfer is opposite for radially inward flow. This configuration leads to nonuniform blade temperature which in unfavorable for blade lifespan. This paper presents a novel eight-passage serpentine design, where passages are arranged along the chord of the blade, to rectify the negative effects of Coriolis force on heat transfer and is an extension four- and six-passage smooth channel studies conducted by the authors earlier. Transient liquid crystal thermography (TLCT) is carried out for detailed measurement of heat transfer coefficients. Heat transfer experiments were performed for Reynolds numbers between 14,264 and 83,616 under stationary conditions. For experiments under rotation, non-dimensional Rotation number is set as 0.05. Heat transfer enhancement levels of nearly twice the Dittus–Boelter correlation (for developed flow in smooth tubes) are obtained under stationary conditions. Under rotation, it is seen that the heat transfer enhancement levels on the leading and trailing sides are similar to each other and also with the stationary condition. Some differences in heat transfer are observed on local level, when rotation cases are compared against the stationary cases. Numerically predicted flow field is presented to support the experimental findings.
Instabilities in metric-affine theories of gravity with higher order curvature terms
Authors: Jiménez Jose Beltrán , Delhom Adrià 
Published: June 2020

AbstractWe discuss the presence of ghostly instabilities for metric-affine theories constructed with higher order curvature terms. We mainly focus on theories containing only the Ricci tensor and show the crucial role played by the projective symmetry. The pathological modes arise from the absence of a pure kinetic term for the projective mode and the non-minimal coupling of a 2-form field contained in the connection, and which can be related to the antisymmetric part of the metric in non-symmetric gravity theories. The couplings to matter are considered at length and cannot be used to render the theories stable. We discuss different procedures to avoid the ghosts by adding additional constraints. We finally argue how these pathologies are expected to be present in general metric-affine theories unless much care is taken in their construction.
Oncogene-Induced Senescence Limits the Progression of Pancreatic Neoplasia through Production of Activin A
Authors: Zhao Yajie , Wu Zhichong , Chanal Marie , Guillaumond Fabienne , Goehrig Delphine , Bachy Sophie , Principe Moitza , Ziverec Audrey , Flaman Jean-Michel , Collin Guillaume , Tomasini Richard , Pasternack Arja , Ritvos Olli , Vasseur Sophie , Bernard David , Hennino Ana , Bertolino Philippe 
Published: June 2020

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a deadly and aggressive cancer. Understanding mechanisms that drive preneoplastic pancreatic lesions is necessary to improve early diagnostic and therapeutic strategies. Mutations and inactivation of activin-like kinase (ALK4) have been demonstrated to favor PDAC onset. Surprisingly, little is known regarding the ligands that drive ALK4 signaling in pancreatic cancer or how this signaling pathway limits the initiation of neoplastic lesions. In this study, data mining and histologic analyses performed on human and mouse tumor tissues revealed that activin A is the major ALK4 ligand that drives PDAC initiation. Activin A, which is absent in normal acinar cells, was strongly induced during acinar-to-ductal metaplasia (ADM), which was promoted by pancreatitis or the activation of KrasG12D in mice. Activin A expression during ADM was associated with the cellular senescence program that is induced in precursor lesions. Blocking activin A signaling through the use of a soluble form of activin receptor IIB (sActRIIB-Fc) and ALK4 knockout in mice expressing KrasG12D resulted in reduced senescence associated with decreased expression of p21, reduced phosphorylation of H2A histone family member X (H2AX), and increased proliferation. Thus, this study indicates that activin A acts as a protective senescence-associated secretory phenotype factor produced by Kras-induced senescent cells during ADM, which limits the expansion and proliferation of pancreatic neoplastic lesions.

Significance:
This study identifies activin A to be a beneficial, senescence-secreted factor induced in pancreatic preneoplastic lesions, which limits their proliferation and ultimately slows progression into pancreatic cancers.
Facts and Hopes in Immunotherapy of Soft-Tissue Sarcomas
Authors: Martín-Broto Javier , Moura David S. , Van Tine Brian A. 
Published: June 2020

AbstractSarcomas are mesenchymal tumors, encompassing more than 175 subtypes, each one with their own genetic complexities. As a result, immunotherapy approaches have not been universally successful across the wide range of diverse subtypes. The actual state of science and the current clinical data utilizing immunotherapy within the soft-tissue sarcomas (STS) will be detailed in this review. More precisely, the review will focus on: (i) the role of the immune microenvironment in the development and activity of new therapeutic approaches; (ii) the recent identification of the sarcoma immune class (SIC) groups, especially group SIC E with its B-cell signature that predicts immunotherapy response; (iii) the clinical trials using PD-1 and/or CTLA-4 inhibitors, which serves as reference for response data, (iv) the promising clinical activity from the combination of anti-angiogenics agents with PD-1 inhibitors, (v) the adapted T-cell therapies for synovial sarcoma that target either NY-ESO or MAGEA4; and (vi) the role for localized therapy using the virotherapy T-VEC with PD-1 inhibitors. Herein, we present the facts and the hopes for the patients with sarcoma, as the field is rapidly advancing its understanding of what and where to use the various types of immunotherapies.
Carotid Atherosclerosis Evolution When Targeting a Low-Density Lipoprotein Cholesterol Concentration <70 mg/dL After an Ischemic Stroke of Atherosclerotic Origin
Authors: Amarenco Pierre , Hobeanu Cristina , Labreuche Julien , Charles Hugo , Giroud Maurice , Meseguer Elena , Lavallée Philippa C. , Gabriel Steg Philippe , Vicaut Éric , Bruckert Eric , Touboul Pierre-Jean 
Published: June 2020

Background:
The TST trial (Treat Stroke to Target) showed the benefit of targeting a low-density lipoprotein cholesterol (LDL-C) concentration of <70 mg/dL in terms of reducing the risk of major cardiovascular events in 2860 patients with ischemic stroke with atherosclerotic stenosis of cerebral vasculature. The impact on carotid atherosclerosis evolution is not known.

Methods:
TST-PLUS (Treat Stroke to Target–Plaque Ultrasound Study) included 201 patients assigned to an LDL-C concentration of <70 mg/dL and 212 patients assigned to a target of 100±10 mg/dL. To achieve these goals, investigators used the statin and dosage of their choice and added ezetimibe as needed. Ultrasonographers were certified and carotid ultrasound examinations were performed using M′Ath software at baseline and at 2, 3, and 5 years. All images were uploaded to the Intelligence in Medical Technologies database directly from the carotid ultrasound device. The central core laboratory performed all offline measurements of the intima–media thickness of both common carotid arteries blinded from the randomization arm. The main outcomes were newly diagnosed atherosclerotic plaque on carotid bifurcation or internal carotid artery using the Mannheim consensus definition and between-group comparison of common carotid arteries intima–media thickness change.

Results:

After a median follow-up of 3.1 years, the achieved LDL-C concentrations were 64 mg/dL (1.64 mmol/L) in the lower-target group and 106 mg/dL (2.72 mmol/L) in the higher-target group. Compared with the higher-target group, patients in the lower-target group had a similar incidence of newly diagnosed carotid plaque: 46/201 (5-year rate, 26.1%) versus 45/212 (5-year rate, 29.7%). The change in common carotid arteries intima–media thickness was −2.69 µm (95% CI, −6.55 to 1.18) in the higher-target group and −10.53 µm (95% CI, −14.21 to −6.85) in the lower-target group, resulting in an absolute between-group difference of −7.84 µm (95% CI, −13.18 to −2.51;
P
=0.004).

Conclusions:
In patients with ischemic stroke and atherosclerosis, an LDL-C target of <70 mg/dL (1.8 mmol/L) did not reduce the incidence of new carotid plaques but produced significantly greater regression of carotid atherosclerosis than an LDL-C target of 90 to 110 mg/dL.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01252875.
Automated Harmonization of Bass Lines from Bach Chorales: A Hybrid Approach
Authors: Wassermann Gilbert , Glickman Mark 
Published: June 2020

Abstract
In this article, a combination of two novel approaches to the harmonization of chorales in the style of J. S. Bach is proposed, implemented, and profiled. The first is the use of the bass line, as opposed to the melody, as the primary input into a chorale-harmonization algorithm. The second is a compromise between methods guided by music knowledge and by machine-learning techniques, designed to mimic the way a music student learns. Specifically, our approach involves learning harmonic structure through a hidden Markov model, and determining individual voice lines by optimizing a Boltzmann pseudolikelihood function incorporating musical constraints through a weighted linear combination of constraint indicators. Although previous generative models have focused only on codifying musical rules or on machine learning without any rule specification, by using a combination of musicologically sound constraints with weights estimated from chorales composed by Bach, we were able to produce musical output in a style that closely resembles Bach's chorale harmonizations. A group of test subjects was able to distinguish which chorales were computer generated only 51.3% of the time, a rate not significantly different from guessing.
Effects of additional neck cut of the femur on the range of motion in total hip arthroplasty for hip dislocation: a computer simulation study
Authors: Makida Kazuya , Seki Taisuke , Osawa Yusuke , Takegami Yasuhiko , Higuchi Yoshitoshi , Kusano Taiki , Ishiguro Naoki 
Published: June 2020

Background: Subtrochanteric shortening osteotomy (SSO) is commonly performed in total hip arthroplasty (THA) for high hip dislocation. However, this procedure is technically difficult and includes complications. Additional neck cut (ANC) of the femur is a procedure that involves femoral shortening by possibly eliminating the need for SSO in THA for high hip dislocation. Herein, we evaluated the effect and the depth limit of ANC of the femur on the range of motion (ROM) in THA for high hip dislocation. Methods: ROM was measured in 26 patients with high hip dislocation using computer software. The stem was deeply positioned at 5-mm intervals from 0 mm to 30 mm (7 groups). The ROM before impingement was measured during flexion, internal rotation (IR) at 90° flexion, external rotation (ER) and abduction. Receiver operator coefficient (ROC) curves for abduction were generated. The cut-off value of ANC where the required ROM was achieved was also determined. Results: Deeper ANCs increased the ROM values during flexion and IR, but they decreased the ROM values during ER and abduction. The ROM values during ER were also limited in 0-mm ANCs. According to the result of the ROC curve for abduction, 15 mm was considered as the permissible range of ANC. Conclusions: In THA for high hip dislocation additional neck cut should be taken into consideration for hips requiring less than 15-mm shortening. For more extended corrections a subtrochanteric shortening osteotomy should be performed.
Acute cardiorenal syndrome in acute heart failure: focus on renal replacement therapy
Authors: Schaubroeck Hannah AI , Gevaert Sofie , Bagshaw Sean M , Kellum John A , Hoste Eric AJ 
Published: June 2020

Abstract
Almost half of hospitalised patients with acute heart failure develop acute cardiorenal syndrome. Treatment consists of optimisation of fluid status and haemodynamics, targeted therapy for the underlying cardiac disease, optimisation of heart failure treatment and preventive measures such as avoidance of nephrotoxic agents. Renal replacement therapy may be temporarily needed to support kidney function, mostly in case of diuretic resistant fluid overload or severe metabolic derangement. The best timing to initiate renal replacement therapy and the best modality in acute heart failure are still under debate. Several modalities are available such as intermittent and continuous renal replacement therapy as well as hybrid techniques, based on two main principles: haemofiltration and haemodialysis. Although continuous techniques have been associated with less haemodynamic instability and a greater chance of renal recovery, cohort data are conflicting and randomised controlled trials have not shown a difference in recovery or mortality. In the presence of diuretic resistance, isolated ultrafiltration with individualisation of ultrafiltration rates is a valid option for decongestion in acute heart failure patients. Practical tools to optimise the use of renal replacement therapy in acute heart failure-related acute cardiorenal syndrome were discussed.
The cholinergic anti-inflammatory pathway alleviates acute lung injury
Authors: Andersson Ulf 
Published: June 2020

AbstractThe ubiquiotous nuclear protein HMGB1 is extracellularly released by dying cells or activated innate immunity cells to promote inflammation. Extracellular HMGB1 plays a prominent role in the pathogenesis of acute lung injury of infectious as well as sterile origin including hyperoxia. Excessive amounts of systemic HMGB1 and HMGB1-partner molecule complexes can be retained in the pulmonary circulation indicated by a substantial reduction of HMGB1 plasma levels in arterial versus venous blood. The cholinergic antiinflammatory mechanism ameliorates pulmonary inflammation by inhibiting HMGB1 release and HMGB1 receptor expression. This comprehension was recently reinforced by results reported in Molecular Medicine by Sitapara and coworkers demonstrating that administration of an α7 nicotinic acetylcholine receptor agonist attenuated hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation. Activating the cholinergic antiinflammatory path might be considered to alleviate severe COVID-19 with or without concurrent oxygen-induced lung injury.
Infrared photovoltaic detector based on p-GeTe/n-Si heterojunction
Authors: Zhao Yiqun , Tang Libin , Yang Shengyi , Lau Shu Ping , Teng Kar Seng 
Published: June 2020

AbstractGeTe is an important narrow bandgap semiconductor material and has found application in the fields of phase change storage as well as spintronics devices. However, it has not been studied for application in the field of infrared photovoltaic detectors working at room temperature. Herein, GeTe nanofilms were grown by magnetron sputtering technique and characterized to investigate its physical, electrical, and optical properties. A high-performance infrared photovoltaic detector based on GeTe/Si heterojunction with the detectivity of 8 × 1011 Jones at 850 nm light irradiation at room temperature was demonstrated.
Nosocomial infections due to multidrug-resistant bacteria in cancer patients: a six-year retrospective study of an oncology Center in Western China
Authors: Jiang Ai-Min , Shi Xin , Liu Na , Gao Huan , Ren Meng-Di , Zheng Xiao-Qiang , Fu Xiao , Liang Xuan , Ruan Zhi-Ping , Yao Yu , Tian Tao 
Published: June 2020

Abstract
Background
Bacterial infections are the most frequent complications in patients with malignancy, and the epidemiology of nosocomial infections among cancer patients has changed over time. This study aimed to evaluate the characteristics, antibiotic resistance patterns, and prognosis of nosocomial infections due to multidrug-resistant (MDR) bacteria in cancer patients.

Methods
This retrospective observational study analyzed cancer patients with nosocomial infections caused by MDR from August 2013 to May 2019. The extracted clinical data were recorded in a standardized form and compared based on the survival status of the patients after infection and during hospitalization. The data were analyzed using independent samples t-test, Chi-square test, and binary logistic regression. P-values < 0.05 were considered significant.

Results
One thousand eight patients developed nosocomial infections during hospitalization, with MDR strains detected in 257 patients. Urinary tract infection (38.1%), respiratory tract infection (26.8%), and bloodstream infection (BSI) (12.5%) were the most common infection types. Extended-spectrum β-lactamase producing Enterobacteriaceae (ESBL-PE) (72.8%) members were the most frequently isolated MDR strains, followed by Acinetobacter baumannii (11.7%), and Stenotrophomonas maltophilia (6.2%). The results of multivariate regression analysis revealed that smoking history, intrapleural/abdominal infusion history within 30 days, the presence of an indwelling urinary catheter, length of hospitalization, and hemoglobin were independent factors for in-hospital mortality in the study population. The isolated MDR bacteria exhibited high rates of sensitivity to amikacin, meropenem, and imipenem.

Conclusions
The burden of nosocomial infections due to MDR bacteria is considerably high in oncological patients, with ESBL-PE being the most predominant causative pathogen. Our findings suggest that amikacin and carbapenems actively against more than 89.7% of MDR isolates. The precise management of MDR bacterial infections in cancer patients may improve the prognosis of these individuals.
Caffeine as a tool for investigating the integration of Cdc25 phosphorylation, activity and ubiquitin-dependent degradation in Schizosaccharomyces pombe
Authors: Alao John P. , Sunnerhagen Per 
Published: June 2020

AbstractThe evolutionarily conserved Cdc25 phosphatase is an essential protein that removes inhibitory phosphorylation moieties on the mitotic regulator Cdc2. Together with the Wee1 kinase, a negative regulator of Cdc2 activity, Cdc25 is thus a central regulator of cell cycle progression in Schizosaccharomyces pombe. The expression and activity of Cdc25 is dependent on the activity of the Target of Rapamycin Complex 1 (TORC1). TORC1 inhibition leads to the activation of Cdc25 and repression of Wee1, leading to advanced entry into mitosis. Withdrawal of nitrogen leads to rapid Cdc25 degradation via the ubiquitin- dependent degradation pathway by the Pub1 E3- ligase. Caffeine is believed to mediate the override of DNA damage checkpoint signalling, by inhibiting the activity of the ataxia telangiectasia mutated (ATM)/Rad3 homologues. This model remains controversial, as TORC1 appears to be the preferred target of caffeine in vivo. Recent studies suggest that caffeine induces DNA damage checkpoint override by inducing the nuclear accumulation of Cdc25 in S. pombe. Caffeine may thus modulate Cdc25 activity and stability via inhibition of TORC1. A clearer understanding of the mechanisms by which caffeine stabilises Cdc25, may provide novel insights into how TORC1 and DNA damage signalling is integrated.