bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Community-Based Program for Exercise and Social Participation for Individuals With Parkinson's Disease: A Multidisciplinary Model
Authors: Moya-Galé Gemma , Rossi Amerigo , States Rebecca A. 
Published: September 2020

Purpose
Parkinson's disease (PD) is a multifaceted condition characterized by motor and nonmotor symptoms that greatly reduce individuals' quality of life. Although treatment models in speech therapy have traditionally focused on a monodisciplinary approach, benefits from allied health care have been reported for over a decade. The purpose of this clinical focus article is to describe the multidisciplinary program developed at Long Island University Brooklyn to address the needs of individuals with PD in an inclusive and diverse setting.

Conclusions
This clinical focus article reviews the importance of multidisciplinary care models in the management of PD and highlights the efforts of our program in building a community-wide range of services to enhance exercise, social participation, and, above all, quality of life in our patients. Future directions of the program are also discussed.
Multi‐phase feedforward ring VCO with high frequency and low phase noise
Authors: Xie Lei , Sang Hao , Chen HaiYan , Liang Bin , Yan Li , Yuan Hengzhou 
Published: September 2020

A novel feedforward‐coupling ring oscillator (FRVCO) is presented. A comparative study in terms of oscillation frequency and phase noise is conducted between the proposed model and the traditional FRVCO. Due to the improved delay cell, high oscillation frequency, low phase noise and uniform multi‐phase output can be achieved. Compared with the traditional FRVCO, under the same design parameters, the FRVCO proposed in this Letter can increase the oscillation frequency by 10% while reducing the phase noise at 1 MHz by at least 10 dB.
Prevalence of BRCA1 and BRCA2 Mutations in Patients with Primary Ovarian Cancer – Does the German Checklist for Detecting the Risk of Hereditary Breast and Ovarian Cancer Adequately Depict the Need for Consultation?
Authors: Ataseven Beyhan , Tripon Denise , Rhiem Kerstin , Harter Philipp , Schneider Stephanie , Heitz Florian , Baert Thais , Traut Alexander , Pauly Nina , Ehmann Sarah , Plett Helmut , Schmutzler Rita K. , du Bois Andreas 
Published: September 2020

Abstract
Background BRCA1/2 mutations are the leading cause of hereditary epithelial ovarian cancer (EOC). The German Consortium for Hereditary Breast and Ovarian Cancer has defined inclusion criteria, which are retrievable as a checklist and facilitate genetic counselling/testing for affected persons with a mutation probability of ≥ 10%. Our objective was to evaluate the prevalence of the BRCA1/2 mutation(s) based on the checklist score (CLS).
Methods A retrospective data analysis was performed on EOC patients with a primary diagnosis treated between 1/2011 – 5/2019 at the Central Essen Clinics, where a BRCA1/2 genetic analysis result and a CLS was available. Out of 545 cases with a BRCA1/2 result (cohort A), 453 cases additionally had an extended gene panel result (cohort B).
Results A BRCA1/2 mutation was identified in 23.3% (127/545) in cohort A, pathogenic mutations in non-BRCA1/2 genes were revealed in a further 6.2% in cohort B. In cohort A, 23.3% (127/545) of patients had a BRCA1 (n = 92) or BRCA2 (n = 35) mutation. Singular EOC (CLS 2) was present in 40.9%. The prevalence for a BRCA1/2 mutation in cohort A was 10.8%, 17.2%, 25.0%, 35.1%, 51.4% and 66.7% for patients with CLS 2, 3, 4, 5, 6 and ≥ 7 respectively. The mutation prevalence in cohort B was 15.9%, 16.4%, 28.2%, 40.4%, 44.8% and 62.5% for patients with CLS 2, 3, 4, 5, 6 and ≥ 7 respectively.
Conclusions The BRCA1/2 mutation prevalence in EOC patients positively correlates with a rising checklist score. Already with singular EOC, the prevalence of a BRCA1/2 mutation exceeds the required 10% threshold. Our data support the recommendation of the S3 guidelines Ovarian Cancer of offering genetic testing to all patients with EOC. Optimisation of the checklist with clear identification of the testing indication in this population should therefore be aimed for.
Current Pharmacological Trends on Myricetin
Authors: Gupta Gudiya , Siddiqui Mohd Aftab , Khan Mohd Muazzam , Ajmal Mohd , Ahsan Rabiya , Rahaman Md Azizur , Ahmad Md Afroz , Arshad Md , Khushtar Mohammad 
Published: September 2020

AbstractMyricetin is a member of the group of ﬂavonoids called ﬂavonols. Myricetin is obtained from various fruit, vegetables, tea, berries and red wine. Myricetin is characterized by the pysrogallol B-ring, and the more hydroxylated structure is known to be capable for its increased biological properties compared with other ﬂavonols. Myricetin is produced by the Myricaceae, Anacardiaceae, Polygonaceae, Pinaceae and Primulacea families. It is soluble in organic solvent such as ethanol, DMSO (dimethyl sulfoxide), and dimethyl formamide (DMF). It is sparingly soluble in aqueous buffers. Myricetin shows its various pharmacological activities including antioxidant, anti-amyloidogenic, antibacterial, antiviral, antidiabetic, anticancer, anti-inﬂammatory, anti-epileptic and anti-ulcer. This review article focuses on pharmacological effects of Myricetin on different diseases such as osteoporotic disorder, anti-inflammatory disorder, alzheimer’s disease, anti-epileptic, cancer, cardiac disorder, diabetic metabolic disorder, hepatoprotective disorder and gastro protective disorder.
Management Dilemmas in Patients with Traumatic Brain Injury on Anticoagulants
Authors: Dwarakanath Srinivas , Deora Harsh 
Published: September 2020

Abstract
Introduction A normal individual with normal hemostasis maintains a balance between thrombus formation and destruction using a complex interaction between the smooth vascular endothelium, the coagulation cascade, the platelet aggregation system, and the fibrinolysis mechanism. However, in patients who are on either antiplatelet drugs (APDs) or anticoagulants (ACDs), this normal homeostasis is altered. This is further altered with traumatic brain injury (TBI) and thus, we need specific guidelines to address this subpopulation to decide the length of observation, avoid unnecessary hospitalization, and relieve the economic burden. There exists a very few randomized controlled trials (RCTs) for this clinical question and a thorough risk–benefit analysis for each patient is prudent before making clinical decisions.
Materials and Methods This is a review article based on available evidence published in literature.
Results There are multiple therapeutic drugs which act on various stages of the coagulation mechanism. These include antiplatelet agents, Vitamin K antagonists, Heparin, Antithrombin III, and Glycoprotein IIb/IIIA inhibitors. While the initial management of head injuries depends on the severity of head injuries, management of head injuries in patients on anticoagulants needs to be approached with care and caution. There are multiple dilemmas including role of CT scans, duration and reason for admission, when to restart anticoagulation, etc. We suggest the recommendations based on available literature; however, no evidence can be given as these are not based on any RCTs, due to paucity of such studies.
Conclusion The guidelines are based on previously conducted trials and consensus. We have attempted to provide a pragmatic and practical approach to such cases with the hope that it will ensure minimum risks with the best possible patient outcomes. The entire journey from patient presentation to follow-up has been covered in this article and we hope this would be useful to all practicing in the field of neurotrauma.
Comparative Evaluation of In-House and Commercial Real-Time PCR Methods for the Detection of the BK and JC Viruses in Clinical Samples
Authors: Özdemir Mehmet , Ayan Uğur , Şevik Murat 
Published: September 2020

Abstract
Aim The two most common human polyomaviruses are the BK (BKV) and JC viruses (JCV). Diseases associated with polyomavirus usually occur in cases of severe cellular immunosuppression. BKV and JCV can cause many diseases, especially if they are reactivated in an immunosuppressed host. The aim of this study is to compare and evaluate the results of real-time polymerase chain reaction (PCR) methods targeting the small and large T gene regions of the viral genome, considering polymorphisms occurring in the viral genome of BKV and JCV.
Materials and Methods Urinary specimens of 82 patients were taken from immunosuppressed patient and sent to molecular microbiology laboratory of Meram Medical Faculty. The small t gene was investigated using a commercial kit (LightMix, Roche) by real-time PCR method. Large T gene was investigated by using the optimized in-house real-time PCR method. Sequence analysis was accepted as the standard method.
Results BKV positivity was detected in 9 samples and JCV positivity in 61 samples by real-time PCR method specific to small t gene region; BKV positivity in 21 samples and JCV positivity in 67 samples were determined by real-time PCR method specific to the large T gene region. Statistically, there was a significant difference for BKV, but not significant difference for JCV detection between the two methods.
Conclusion Different polymorphisms in the target gene regions were responsible for the different outcomes obtained from this study. With this sensitivity and specificity, in-house PCR method which we used is a candidate for routine diagnosis.
Distribution of Lymphoma Subtypes in Bihar—Analysis of 518 Cases Using the WHO Classification of Lymphoid Tumors (2017)
Authors: Lisa Mona , Verma Pranab Kumar , Mustaqueem Syed Fiza ,   Shuchismita,   Nishi
Published: September 2020

Abstract
Introduction The prevalent spectrum of the major subtypes of lymphoma varies across geographical regions. Through this study we aim to study the distribution of lymphoma in the state of Bihar by studying the immunophenotypic features and classifying them according to World Health Organization (WHO) 2017. To the best of our knowledge, this is the first study of this type from Bihar
Patients and Methods All the cases diagnosed as lymphoma between January 2016 and June 2019 in the Department of Pathology Mahavir Cancer Sansthan were included in the study. The cases were reviewed by two pathologists and diagnostically difficult cases were referred to higher center for opinion. A total of 518 cases were diagnosed as lymphoma.
Results B cell lymphomas formed 79.1%, whereas T cell lymphomas formed 16.2% of the total. Hodgkin lymphoma (HL) was seen in 19.6% cases. Among the non-Hodgkin lymphoma (NHL), diffuse large B cell lymphoma was the most common subtype (58% of all NHLs). Follicular center-cell lymphomas, B cell small lymphocytic lymphoma, mantle-cell lymphoma, and marginal zone B cell lymphomas (including mucosa-associated lymphoid tissue lymphomas) amounted to 2.1, 6.9, 4.5, and 0.95%, respectively. Among the T cell lymphomas, T cell lymphoblastic lymphoma, anaplastic large-cell lymphomas of T/null-cell type, and other nodal peripheral T cell lymphomas accounted for 4.7, 8.1 and 6.6% of all cases, respectively.
Conclusions The prevalence of lymphoma subtypes in India is different from the rest of the world. We have analyzed the distribution of lymphomas in Bihar and compared it with other studies from India. Follicular lymphoma and mantle-cell lymphoma are less common in India compared with the west. Peripheral T cell lymphomas and T/NK-cell lymphomas of nasal types are less prevalent than some Asian countries but are more prevalent than the west. T cell lymphoblastic lymphoma and anaplastic large T/null cell lymphoma are more common in India.
Preconceptions in Mechanics
Authors: Camp Charles W. , Clement John J. 
Published: September 2020

This second edition of Charles Camp and John Clement's book contains a set of 24 innovative lessons and laboratories in mechanics for high school physics classrooms that was developed by a team of teachers and science education researchers. Research has shown that certain student preconceptions conflict with current physical theories and seem to resist change when using traditional instructional techniques. This book provides a set of lessons that are aimed specifically at these particularly troublesome areas: Normal Forces, Friction, Newton's Third Law, Relative Motion, Gravity, Inertia, and Tension. The lessons can be used to supplement any course that includes mechanics.
Each unit contains detailed step by step lesson plans, homework and test problems, as_ well as background information on common student misconceptions, an overall integrated teaching strategy, and key aspects of the targeted core concepts. This edition has a number of substantial changes based on teacher input. A number of the lessons are adaptable for college level courses as well. Evaluations using pre-and post-tests have shown large gain differerfces over control groups.
The evidence-based intervention for teaching the Chinese language in Australian classrooms
Authors: Yan Dave 
Published: September 2020

Abstract
There is a lack of research on evidence-based intervention in relation to the issue of L2 variations in secondary
schools. This study addresses some conceptual problems of L2, proposing a four-quadrant model of language processes. This model
provides a framework to identify students’ L2 developmental stages. With an action research method, the data were collected from
126 Chinese language learners in Australia over a 4-year period (2016–2020). The main instruments were questionnaires, class
observations, informal interviews, and student feedback. The findings revealed that most learners were initially motivated to
learn the Chinese language in year 9, even if they were at varying stages of L2 development. While several factors were
interplayed to affect their language experience, the findings underscored the implementation of a range of plausible
interventions. The effectiveness of the intervention was measured by student engagement, and further backed by the retention rates
of year 12 students. This study provides a beginning to the evidence base, necessary to design Chinese language interventions in
Australia.
North Caucasian consumer model of economic growth: factors and mechanisms
Authors: Uyanayeva Kh , Kokov N , Toguzayev T , Kuchukov M , Alibius F 
Published: September 2020

Abstract
Socio-economic development management of large territorial complexes requires knowledge of their development model. In historical practice, two large economic development models of territories appeared: consumer model and investment model. The basis of the first one is the demand (needs) of people living in the territory, of the second it is investment in the main capital of territorial economic entities and large infrastructure projects. Essentially, these two models are not based on two mutually exclusive, but on two mutually reinforcing directions of territorial socio-economic development. But anytime there is dominance (and preference) of one or the other direction. Moreover, if we consider their implementation in terms of end results - economic growth rates, expressed in synthetic indicators of territory development, for example, GRP, it turns out that in this regard there is no obvious prefer-ence of one over the other. The model of territory socio-economic development based on consumption is relatively conservative evolutionary in nature. As for the investment model, it is more revolutionary in nature and depends on the volume and structure of investments coming into the territorial complex. The authors analyzed the socio-economic development state of a large territorial complex - the North Caucasus Federal District, based on official statistics and long-term observations. They revealed the features of existing development model, formalized and quantified the dependencies of GRP and the factors that ensure its growth. The authors also formulated conclusions and suggestions.
Development of a KPI system for pig farms based on the criteria for evaluating the efficiency of the enterprise
Authors: Chichenkov I , Faizullin R 
Published: September 2020

Abstract
In the article we consider the main criteria for the effectiveness of the pig-breeding enterprise. We conducted a comparative analysis of the approaches considered by various authors and selected the most popular indicators, followed by an explanation of the significance and importance of each of them. A system of criteria for evaluating the effectiveness of a pig-breeding enterprise has been developed. The use of the following indicators is proposed: the number of piglets from one main sow (per farrow and per year); number of farrowing per year; average daily gain (in fattening and in the herd as a whole); feed conversion (for the herd, taking into account the costs of the parent herd and for fattening); profitability (loss ratio)%; age of livestock being slaughtered, days; and average live weight of sales, kg. It is proved that one of the organizational and economic mechanisms of enterprise performance management is the development of such a system of key performance indicators of personnel performance, which determines the dependence of the company’s performance on the performance indicators of personnel. A system of key indicators of personnel efficiency is proposed, labor stimulation is determined to improve these indicators in this research, which ultimately leads to an increase in the efficiency of the enterprise as a whole.
Current Russian agricultural development trends
Authors: Borisov A I , Danilova S S 
Published: September 2020

Abstract
In article the main questions connected with development of domestic agricultural producers are considered, in particular, the main directions of development are allocated. In article it is told about trends of development of agriculture in the conditions of the international sanctions and also development of the technological direction in means of UAVs, robots, innovative machines and the equipment. Also the main issues of development of meat production as one of the most priority directions of development of agriculture are considered in article.
Food security structure and agribusiness
Authors: Trofimova S A , Trofimova I B , Gotsko L G 
Published: September 2020

Abstract
The article explores the conditions of food security as one of the development goals of the third millennium, proclaimed by the UN. It analyzes the contradictory nature of these conditions. The study identifies the most significant elements of the food security structure to determine the directions of agribusiness activity and increase the level of food security in Russia. The structure of food security comprises several elements: political, economic, scientific and innovative, demographic, psychological. Each of the components is given a characteristic and the degree of significance of each element is analyzed. The study identifies the most important directions for the development of agribusiness of various forms of ownership and various organizational and legal forms: from farms to agriholdings, taking into account the goals of sustainable development to ensure food security, improve nutrition, and develop agriculture.
The experimental data on the density, viscosity, and boiling temperature of the coffee extract
Authors: Khomyakov A P , Mordanov S V , Khomyakova T V 
Published: September 2020

Abstract
The paper shows the experimental data on the density, viscosity, and boiling temperature of the coffee extract. The mass fraction of the dry substances varies in the range of 15-70 % for all measurements. The coffee extract temperature varies in the rage of 20-80 °C for the density and viscosity measurements. It is found that the coffee extract density varies in the range of 1030-1350 kg/m3 for the considered cases. The coffee extract viscosity varies in the range of 0.0008-27.4810 Pa·s for the considered cases. The coffee extract boiling temperature varies in the range of 100.0-103.3 °C at atmospheric pressure. It was found that the coffee extract is foaming in the considered range of dry substances mass fraction. The foaming temperature is decreasing with the dry substances mass fraction increasing.
Tools for prioritizing the development of industrial and agricultural territories of the region
Authors: Urasova A A , Krasilnikov D G , Mukhin M A , Balandin D A 
Published: September 2020

Abstract
The article reveals the possibilities of applying the methods of ranking big data based on the search for the Kemeny median in order to diagnose priorities in the development of industrial and agricultural territories of the region. The authors obtained conclusions regarding the balanced development of territories, revealed a general trend in the economic and industrial areas. This made it possible to take into account the unstructured nature of data with various metrics, as well as diagnose groups of indicators that are crucial in the industrial and agro-industrial development of the region, and determine priorities in individual territories.
A new approach to the analysis of complex biological systems
Authors: Neuymin S I , Olshvang O Yu , Katsman S I 
Published: September 2020

Abstract
A new approach to the analysis of biological systems according to the complexes of related elements is suggested. Rules for integral transformation of sets of attributes in biosystems are developed. For the first time, the resulting indicator of the system of contraction mappings (Ri SCM) that we developed was used for the analysis of biological systems. A comprehensive study of biosystems is largely determined by the algorithm for converting the totality of sequences of its elements. The structural and mathematical analysis of the complex of related elements which was used reflects the homologous variability of biological systems, based on which the classification of combinations of attributes is carried out.
Some issues related to the study of brucellosis in Uzbekistan
Authors: Ulugmuradov A D , Uzimurodov M A 
Published: September 2020

Abstract
This article provides some points on the fight against brucellosis in Uzbekistan as well as independent research on epizootology, chronology, characterization of anti-brucellosis vaccines and the properties of brucella strains with different species and virulence. The research results allow us to replenish the collection of standards of industrial crops of brucella that are necessary for the development of domestic production of anti-brucellosis vaccines and diagnosticums, as well as create national reference strains of brucella designed to control their quality. Knowledge of the properties of epizootic strains of brucella circulating in a particular territory allows us to classify farms and assess the degree of tension of epizootic and epidemic processes, to establish the fact of migration of brucella from one animal species to another, to identify pathways of pathogen distribution, and the choice of tactics for conducting antiepizootic measures. The presented comparative characteristic of anti-brucellosis vaccines enables specialists to choose the most effective and acceptable when carrying out measures for the prevention and elimination of this disease.
Efficiency of biologization of agriculture in Western Siberia (on the example of the Omsk region)
Authors: Voronkova N A , Bobrenko I A , Nevenchannaya N M , Popova V I 
Published: September 2020

Abstract
Biological intensification of agriculture is one of the main factors in maintaining soil fertility and optimizing the mineral nutrition of plants, while ensuring an increase in crop yields and improving the quality of farmed products while saving resources and environmental safety. On the basis of studying the effectiveness of biologization techniques in agriculture of the chernozem forest-steppe of Western Siberia (on the example of the Omsk region), the optimal options for the rational use of fertilizers in combination with local biological resources, which reduce the dose of fertilizers and increase the return on additional products, are determined. The environmental focus of research associated with the study of the possibility of maximum involvement of biological resources in the region’s agriculture is undoubtedly relevant in modern conditions.