bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensory Processing Patterns affect Headache Severity among Adolescents with Migraine
Authors: Genizi Jacob , Halevy Ayelet , Schertz Mitchell , Osman Khaled , Assaf Nurit , Segal Idan , Sr Isaac , Kessel Aharon , Engel-Yeger Batya 
Published: May 2020

Abstract
Objective: To evaluate the relationship between pain catastrophizing level, sensory processing patterns, and headache severity among adolescents with episodic migraine. Background: Catastrophizing about pain is a critical variable in how we understand adjustment to pain and has a unique contribution in predicting pain intensity. Recent reports found that migraine is also related to enhanced sensory sensitivity. However, the relationship between pain severity, pain catastrophizing level and sensory sensitivity requires greater study especially among adolescents. Methods: Participants were 92 adolescents aged 13-18 years, 40 with episodic migraine and 52 healthy controls. The migraine patients were prospectively recruited from outpatient pediatric neurology clinics. All participants completed the Adolescent/Adult Sensory Profile (AASP), and the Pain Catastrophizing Scale for children (PCS-ch). The migraine groups also completed the PedMIDAS, which measures Headache related disability. Results: Adolescents with migraine had significantly lower tendency to seek sensory input than healthy controls. Elevated rumination and helplessness correlated with higher migraine pain severity. Tendency to avoid sensory input predicted the migraine related disability level. They also significantly higher pain catastrophizing level than healthy controls, as seen in enhanced rumination (p ≤ 0.001) and helplessness (p ≤ 0.05). Conclusions: Sensory processing difficulties are common among adolescents with episodic migraine. Sensory avoidance may be related to pain experience, and pain catastrophizing and disability level.
Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma
Authors: Ahn Sung Woo , Ahn Ae-Ri , Ha Sang Hoon , Hussein Usama Khamis , Yang Jae Do , Kim Kyoung Min , Park Ho Sung , Park See-Hyoung , Yu Hee Chul , Jang Kyu Yun 
Published: May 2020

Abstract
Background Recently, FAM83H was reported to have roles in cancer progression in conjunction with oncogenic molecules such as MYC and b-catenin. Moreover, the data from the public database indicates a molecular relationship between FAM83H and zinc finger proteins, especially between FAM83H and ZNF16. However, studies on FAM83H and ZNF16 in gallbladder cancer have been limited. Methods This study investigated the expression of FAM83H and ZNF16 in 105 gallbladder carcinomas. Results In human gallbladder carcinomas, immunohistochemical expression of FAM83H was significantly associated with ZNF16 expression. In univariate analysis, nuclear and cytoplasmic expression of FAM83H or ZNF16 were significantly associated with shorter survival of gallbladder carcinoma patients. Multivariate analysis revealed the nuclear expression of FAM83H as an independent indicator of poor prognosis of overall survival ( p = 0.005) and relapse-free survival ( p = 0.005) of gallbladder carcinoma patients. Moreover, co-expression patterns of nuclear FAM83H and ZNF16 were also independent indicators of shorter survival of gallbladder carcinoma patients (overall survival; p < 0.001, relapse-free survival; p < 0.001). Conclusions This study suggests FAM83H and ZNF16 are associated with the progression of gallbladder carcinoma, and the expressions of FAM83H and ZNF16 might be novel prognostic indicators of gallbladder carcinoma patients.
Trends of Caesarean Section Deliveries in Pakistan: Secondary Data Analysis from Demographic and Health Surveys, 1990-2018
Authors: Amjad Aaisha , Imran Abeeha , Shahram Nabeeha , Zakar Rubeena , Usman Ahmad , Zakar Muhammad Zakria , Fischer Florian 
Published: May 2020

Abstract
Background Pakistan is amongst those countries where the number of caesarean section births has unusually increased in the past two decades. Therefore, the aim of the present study is to analyse the trend of caesarean section deliveries among child-bearing women (aged 15–49 years) in Pakistan and to identify maternal socio-demographic factors and pregnancy related variables associated with the change in caesarean deliveries from 1990 to 2018.Methods Secondary data from Pakistan Demographic and Health Surveys (1990–2018) were analysed. The analysis of data was confined to the child-bearing mothers. Sample sizes were 4,029, 5,721, 7,461 and 8,287 for the time period of 1990–91, 2006–07, 2012–13, and 2017–18, respectively. For the present study, socio-demographic information of the mothers and pregnancy related variables were taken as independent variables. The association between independent variables and caesarean deliveries was measured in terms of unadjusted odds ratios (OR) and adjusted odds ratios (AOR).Results Out of the mothers who had at least one delivery during the five years prior to each survey, the percentages of the mothers who had caesarean deliveries increased continuously from 3.2% in 1990–91 to 19.6% in 2017–18. Results indicate that mothers above 24 years of age, located in Punjab, from the richest socio-economic class, and living in urban areas were more likely to have delivered by caesarean section. Mothers with first child in birth order and who had five and above children, as well as mothers who had more antenatal care visits and delivered babies in private hospitals showed a higher probability for caesarean section births.Conclusions The findings of the present study confirm the gradual upsurge in the percentage of mothers delivering through caesarean section during the past two decades in Pakistan. In this backdrop, some measures need to be taken by health departments to regulate the number of caesarean deliveries. Awareness among women about pregnancy complications and elaborated details by gynaecologists about the medically indicated reasons of caesarean delivery are a few important steps that can help in reducing not medically indicated caesarean deliveries in Pakistan.
Systemic and local diseases associated with the development of diabetic macular edema among Japanese patients with diabetes mellitus
Authors: Kume Atuki , Kashiwagi Kenji 
Published: May 2020

Abstract
Background
Diabetic macular edema (DME) causes severe vision loss among patients with diabetes mellitus (DM). We aimed to investigate systemic and local diseases associated with the development of DME among a Japanese population.
Methods
A total of 3.11 million Japanese subjects who were registered in the database of the Japan Medical Data Center from 2005 to 2014 were analyzed. Subjects with DM were defined as individuals who had been prescribed any therapeutic medications for DM, and associated diseases were analyzed. The periods analyzed were one year before the development of DME among patients with DME and one year before the last visit to an ophthalmic clinic among patients without DME.
Results
A total of 17,403 patients with DM satisfied the inclusion and exclusion criteria, and 420 patients developed DME. Univariate analysis revealed significant associations between 55 diseases, including 39 systemic and 16 local diseases, and DME development. The logistic analysis identified 21 systemic diseases and 10 local diseases as significant factors associated with DME development. Various types of systemic and local diseases were associated with DME development.
Conclusion
Subjects with DM who present these risk factors must be carefully monitored to prevent visual impairment.
Optimize Outpatient Pharmacy Service Process: Shorten Waiting Time and Improve Patient Satisfaction
Authors: He Wenqiong , Xu Qian , Yang Jiayong , Liu Feng 
Published: May 2020

Abstract
Background: To provide scientific decision-making basis for managers to improve management methods, so about make outpatient pharmacy service flow smoother and more efficient, shorten the waiting time for patients to take medicine and improve patient satisfaction.Methods: Based on the concept of BI, the existing data onto outpatient pharmacy in our hospital were analyzed in depth, and the time distribution rule of prescription dispensing was found. By real-time analysis of the number of patients in the upstream link to the medication withdrawal step, the early warning of the number of patients was realized. Regularity and real-time early warning of the number of medicines users should establish a flexible and efficient scheduling system for pharmacists, so about maximize the use efficiency of human resources in outpatient pharmacies. Mean while, rearranged the medicines shelves according to the relevancy analysis of medicines in the same prescription, to reduce the walking distance of staff.Results: Based on the optimization of outpatient service process of large data, the waiting time for patients to take medicine was shortened from more than 15 minutes to less than 10 minutes, satisfaction increased from less than 65% to more than 85%, and the use of personnel was maximized.Conclusions: Through in-depth analysis and deep excavation of the real-time monitoring of outpatient prescription volume, managers can improve the outpatient service process, and through the monitoring and early warning of outpatient prescription volume, employees can be arranged, which is helpful to realize the digital, refined and intelligent management of the hospital.
Clinically Relevant Postoperative Pancreatic Fistula rates in two methods of pancreatico-jejunal anastomosis compared: Evolution of surgical technique in a single centre over time
Authors: Zurleni Tommaso , Olmetti Simone , Marzoli Luca , Zurleni Francesco 
Published: May 2020

Abstract
Background:Pancreaticoduodenectomy remains the gold standard for management of patients with pancreatic head and periampullary neoplasms. Despite the low mortality, overall morbidity remains high, principally due to the development of a clinically relevant postoperative pancreatic fistula (CR-POPF).The aim of the present study is to compare rates of CR-POPF in two groups of patients treated with two different pancreaticojejunostomy techniques. Methods:Among 264 consecutive patients submitted to surgery for pancreatic neoplasm, 142 pancreaticoduodenectomies with end-to-side pancreaticojejunostomy were analysed. The first group of patients underwent a direct mucosa-to-mucosa anastomosis as described by Longmire and Traverso. In the second group, a duct-to-mucosa anastomosis with an outer seromuscolar and inner full thickness layer as described by Z’graggen, Shrikhande and Buchler was performed. Results:Mortality was 2,8% in the first group (2/71) and zero in the second. In group 1°, 48.5% of patients suffered one or more grade II-V Clavien-Dindo complications; in group 2°, complications were observed in 26,7% of patients. Clinically relevant POPF occurred in 12 patients in group 1° (17%) and in 4 patients in group 2° (5,6%). Conclusions:Changing pancreaticojejunostomy techniques may produce different outcomes. In our experience, a standardized duct-to-mucosa anastomosis, as performed in group 2, significantly reduced the rate of CR-POPF.
Health status, lifestyle habits, and perceived social support in long-term cancer survivors: a cross-sectional study
Authors: León-Salas Beatriz , Zabaleta-del-Olmo Edurne , LLobera Joan , Bolíbar-Ribas Bonaventura , López-Jiménez Tomas , Casajuana-Closas Marc , Cantó Magdalena Esteva 
Published: May 2020

Abstract
Background: The purpose of this study was to compare health status, lifestyle habits, and perceived social support between cancer survivors and people who have never had cancer. Methods: Descriptive, cross-sectional multicenter study nested in phases II and III of the cluster randomized clinical trial ERIA, designed to analyze the effects of a complex primary care intervention compared with care as usual on smoking cessation, improved adherence to the Mediterranean diet, and increased physical activity. For the cross-sectional study, patients were divided into two groups: cancer survivors and people who had never had cancer (controls). Thirty eight Primary care centers Spanish provinces of Barcelona, Girona, Balearic Islands, Malaga, Seville, Salamanca, Soria, Toledo, Vigo, Vizcaya, and Zaragoza. Adults aged between 45 and 75 years with at least two risk behaviors. Patients being treated for active cancer or in end-of-life care were excluded.Primary outcomes: Sociodemographic variables, diet, physical activity, smoking, body mass index, Charlson Comorbidity Index, and self-perceived health and social support.Results: Of the 4259 people included, 190 (4.46%) were cancer survivors. Their mean±SD age was 62.8±7 years versus 58.7±8 years (P<0.01) for people who had never had cancer. Long-term sick leave was also more common in this group (11.9% vs 3.5%, P<0.001). No between-group differences were observed for smoking, adherence to the Mediterranean diet, physical activity, obesity, or perceived social support. Cancer survivors reported worse health (OR 1.82; IC95% 1.02–2.75) and were more likely to have two or more comorbid conditions (OR 1.68; 95% CI 1.18–2.39), chronic pulmonary obstructive disease (OR 2.17; 95% CI 1.25–3.78), and depression (OR 1.65; 95% CI 1.06–2.57). In the multiple regression analysis, older age and worse self-perceived health continued to be significantly associated with having survived cancer.Conclusions: Cancer survivors have more chronic diseases, a greater likelihood of being on long-term sick leave, and worse self-perceived health than people without a history of cancer, regardless of age. The two groups perceived similar levels of social support.
Postoperative cognitive recovery in children after both general and locoregional anesthesia and surgery
Authors: Hammoumi Jalal El , Dahchour Abdelkader , Chhiti Elmehdi , Benlamkadem Saïd , Berdai Mohamed-Adnane , Harandou Mustapha , Boujraf Saïd 
Published: May 2020

Abstract
Background and objectivesRecent researches have demonstrated that there is a progressive impairment in neurocognitive function following general anesthesia and surgery, and particularly, have evidenced that anesthetics impaired mechanisms of learning and memory, for days to months, in both adults and children.This study aimed to evaluate the influence of different types of anesthesia (General or Locoregional) on cognitive recovery by trial and error method, and also take into consideration other factors that would have an impact on the cognitive performance after anesthesia and surgery in children.MethodsIn the present cross-sectional study, 64 young children, aged between 10 and 15 years, have passed the CALM test (software based on trial and error method) 24h after their surgery, and the operating file filled by the anesthetist. The statistical analysis includes a descriptive part of our sample, a univariate, and multivariate analysis of the results of the CALM test and the various medical factors and lifestyles.Results and conclusionsThe cognitive performance of patients exposed to locoregional anesthesia (81.3%) was higher (p=0.01) when compared to patients under general anesthesia (34.4%). Both agitation (Neurological state) and postoperative pain significantly (p=0.02) altered the cognitive performance of patients. However, none of the other factors assessed such as gender, environmental living, schooling, pre-anesthetic consultation, and the type of intervention affects the postoperative cognitive performance of patients.Locoregional anesthesia has less effect on cognitive recovery when compared to general anesthesia. Both the postoperative pain and agitation alter cognitive performances of operated children.
Forsythoside B attenuates memory impairment and neuroinflammation via inhibition on NF-κB signaling in Alzheimer’s disease
Authors: Kong Fan’ge , Jiang Xue , Wang Ruochen , Zhai Siyu , Zhang Yizhi , Wang Di 
Published: May 2020

Abstract
BackgroundAlzheimer’s disease (AD) is a type of progressive neurodegenerative disease related to neuroinflammation. Forsythoside B (FTS•B), a phenylethanoid glycoside isolated from plants, has been reported to exert various pharmacological effects. However, the neuroprotection of FTS•B related to neuroinflammation has not been systemically reported.MethodsIn amyloid precursor protein/presenilin 1 (APP/PS1) mice, behavioral tests including Morris water maze, Y maze and open field experiment were used to examine the cognitive function. Immunohistochemistry were used to analyze amyloid-beta (Aβ) deposition, Tau protein phosphorylation, the levels of 4-hydroxynonenal (4-HNE), glial fibrillary acidic protein (GFAP) and ionized calcium binding adapter molecule 1 (Iba1). Remarkably changed proteins related to neuroinflammation were filtered via proteomics and verified via enzyme-linked immunosorbent assay (ELISA) and western blot. Besides, BV-2 cells and HT22 cells were used to confirm the anti-neuroinflammation of FTS·B.ResultsFTS·B counteracted cognitive decline, ameliorated Aβ deposition and Tau protein phosphorylation, attenuated microglia and astrocytes activation in the cortex and/or hippocampus. Furthermore, FTS·B affected vital signaling, particularly by decreasing the activation of JNK-interacting protein 3/C-Jun NH2-terminal kinase (JIP3/JNK) and suppressing WD-repeat and FYVE-domain-containing protein 1/toll-like receptor 3 (WDFY1/TLR3), further suppressing the activation of nuclear factor-κB (NF-κB) signaling. In BV-2 and HT22 cells, FTS·B prevented lipopolysaccharide (LPS)-induced neuroinflammation and reduced the microglia-mediated neurotoxicity.ConclusionsFTS·B counteracted cognitive decline by triggering neurogenesis via signaling associated with inflammation, suggesting the promising therapeutic effects of FTS·B on AD treatment.# The two authors contribute equally to the project
Deceased donor kidney allocation : an economic evaluation of contemporary longevity matching practices
Authors: Senanayake Sameera , Graves Nicholas , Healy Helen , Baboolal Keshwar , Barnett Adrian , Sypek Matthew P. , Kularatna Sanjeewa 
Published: May 2020

Abstract
Background: Matching survival of a donor kidney with that of the recipient (longevity matching), is use in some kidney allocation systems to maximize graft-life years. It is not part of the allocation algorithm for Australia. Given the growing evidence of survival benefit due to longevity matching based allocation algorithms, development of a similar kidney allocation system for Australia is currently underway. The aim of this research is to estimate the impact that changes to costs and health outcomes arising from ‘longevity matching’ on the Australian healthcare system. Methods: A decision analytic model to estimate cost-effectiveness was developed using a Markov process. Four plausible competing allocation options were compared to the current kidney allocation practice. Models were simulated in one-year cycles for a 20-year time horizon, with transitions through distinct health states relevant to the kidney recipient. Willingness to pay was considered as AUD 28000. Results: Base case analysis indicated that allocating the worst 20% of Kidney Donor Risk Index (KDRI) donor kidneys to the worst 20% of estimated post-transplant survival (EPTS) recipients (option 2) and allocating the oldest 25% of donor kidneys to the oldest 25% of recipients are both cost saving and more effective compared to the current Australian allocation practice. Option 2, returned the lowest costs, greatest health benefits and largest gain to net monetary benefits (NMB). Allocating the best 20% of KDRI donor kidneys to the best 20% of EPTS recipients had the lowest expected incremental NMB. Conclusion: Of the four longevity-based kidney allocation practices considered, transplanting the lowest quality kidneys to the worst kidney recipients (option 2), was estimated to return the best value for money for the Australian health system.
Microglial and peripheral immune priming is partially sexually dimorphic in adolescent mouse offspring exposed to maternal high-fat diet
Authors: Bordeleau Maude , Lacabanne Chloé , de Cossío Lourdes Fernández , Vernoux Nathalie , Savage Julie C. , González-Ibáñez Fernando , Tremblay Marie-Eve 
Published: May 2020

Abstract
Background
Maternal nutrition is critical for proper fetal development. While increased nutrient intake is essential during pregnancy, an excessive consumption of certain nutrients, like fat, can lead to long-lasting detrimental consequences on the offspring. Animal work investigating the consequences of maternal high-fat diet (mHFD) revealed in the offspring a maternal immune activation (MIA) phenotype associated with increased inflammatory signals. This inflammation was proposed as one of the mechanisms causing neuronal circuit dysfunction, notably in the hippocampus, by altering the brain-resident macrophages –microglia. However, the understanding of mechanisms linking inflammation and microglial activities to pathological brain development remains limited. We hypothesized that mHFD-induced inflammation could prime microglia by altering their specific gene expression signature, population density and/or functions.
Methods
We used an integrative approach combining molecular techniques, confocal and scanning electron microscopy, to investigate the effects of mHFD vs control diet on inflammatory priming, as well as microglial density, distribution, morphology, and ultrastructure in mice. These analyses were performed on the mothers, and/or their adolescent offspring at postnatal day (P) 30.
Results
Our study revealed that mHFD results in MIA defined by increased circulating levels of interleukin (IL)-6 in the mothers. This phenotype was associated with an exacerbated inflammatory response to peripheral lipopolysaccharide in mHFD-exposed offspring of both sexes. Microglial morphology was also altered and there were increased microglial interactions with astrocytes in the hippocampus CA1 of mHFD-exposed male offspring, as well as decreased microglia-associated extracellular space pockets in the same region of mHFD-exposed offspring of the two sexes. A decreased mRNA expression of the inflammatory-regulating cytokine Tgfb1 and microglial receptors Tmem119, Trem2 and Cx3cr1 was additionally measured in the hippocampus of mHFD-exposed offspring, especially in males.
Conclusions
Here, we described how dietary habits during pregnancy and nurturing, particularly the consumption of an enriched fat diet, can influence peripheral immune priming in the offspring. We also found that microglia are affected in terms of gene expression signature, morphology and interactions with the hippocampal parenchyma, in a partially sexually dimorphic manner, which may contribute to the adverse neurodevelopmental outcomes on the offspring.