bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manifestations of Skull Base IgG4‐Related Disease: A Multi‐Institutional Study
Authors: Marinelli John P. , Marvisi Chiara , Vaglio Augusto , Peters Pierce A. , Dowling Eric M. , Palumbo Alessandro A. , Lane John I. , Appelbaum Eric N. , Sweeney Alex D. , Carlson Matthew L. 
Published: December 2019

ObjectiveIgG4‐related disease (IgG4‐RD) is a recently recognized disease characterized by fibroinflammatory infiltrates rich in IgG4+ plasma cells that can present as isolated tumor‐like lesions of the head and neck. The objective of the current study was to describe the cranial base manifestations of IgG4‐RD.MethodsReview of all cases at three tertiary‐referral centers since disease description in 2003.ResultsEleven patients were identified at a median age at presentation of 58 years (IQR, 38–65; 55% male). Ten (91%) patients had isolated skull base masses without systemic disease. Cranial neuropathies were commonly observed in the abducens (45%), trigeminal (18%), and facial nerves (18%). Lesions frequently involved the cavernous sinus (55%; 6/11) with extension to the petroclival junction in 50% (3/6). Infiltration of the internal auditory canal was present in 27% (3/11) with one case demonstrating erosion of the bony labyrinth. Preliminary clinical diagnoses commonly included nasopharyngeal cancer, pituitary macroadenoma, cholesteatoma, and meningioma / multiple meningioma syndrome. Local biopsy demonstrated >30 IgG4‐positive plasma cells per high‐powered field or an IgG4:IgG ratio greater than 40% in all cases. Rapid and durable clinical improvement was seen in 91% following corticosteroid and rituximab therapy.ConclusionsIgG4‐RD nonspecifically presents as a rare cause of the skull base mass. Often presenting without concomitant systemic disease, local diagnostic biopsies are required. Obtaining adequate tissue specimen is complicated by densely fibrotic cranial base lesions that are frequently in close proximity to critical neurovascular structures. Primary medical therapy with corticosteroids and rituximab is effective in most patients.Level of Evidence4 Laryngoscope, 130:2574–2580, 2020
Priming skepticism: Unintended consequences of one‐sided persuasion knowledge access
Authors: Isaac Mathew S. , Grayson Kent 
Published: December 2019

AbstractScholars have historically assumed that consumers' persuasion knowledge is invariably linked to skepticism about advertising and marketing. As a result, studies have often used skepticism‐focused stimuli to prompt persuasion knowledge access. However, as originally conceptualized, persuasion knowledge also includes an understanding of persuasion tactics that are trusted and believed, which suggests that accessing persuasion knowledge does not necessarily make consumers more skeptical. In this paper, we propose that, for at least some persuasion knowledge research questions, skepticism‐focused interventions may be too “one‐sided” because they bias participants to consider only the skeptical side of persuasion knowledge. The purpose of the present research is to test whether the “one‐sided” persuasion knowledge interventions that are used in persuasion knowledge research encourage skepticism more than balanced interventions that focus consumers on the negative and positive motives that may underlie persuasive communication. Across three experiments with three distinct subject pools and over 2,500 participants, we demonstrate that one‐sided versus balanced manipulations of persuasion knowledge can have differential effects on consumer skepticism. This is an important finding because skepticism‐focused operationalizations are frequently employed in persuasion knowledge research.
Marketing capabilities and innovation. How do they affect the financial results of hotels?
Authors: Revilla‐Camacho María‐Ángeles , Palacios‐Florencio Beatriz , Garzón Dolores , Prado‐Román Camilo 
Published: December 2019

AbstractFrom the point of view of firms’ managers, the knowledge of the factors which explain their firms’ financial results is considered of great usefulness to propose the most appropriate and profitable marketing strategies and actions. This research sets out from this central idea and proposes a model of relationships that considers the marketing results, the marketing capabilities, and the innovation capability as key factors for achieving good financial results. This model is verified via an empirical investigation carried out among 200 directors of hotel establishments in Andalusia, a region in the south of Spain which is one of the country's main tourist destinations. The results indicate that innovation capability is strongly conditioned by marketing capabilities and resources and that this innovation capability affects the financial results of the firms analyzed. Likewise, it is deduced that a market‐oriented management philosophy contributes to the development of these marketing capabilities. The implications for management are considered very relevant as they must lead these firms to invest in the development of marketing resources and capabilities, and apply a market‐oriented management philosophy if they wish to improve their financial results.
Fifty shades of food: The influence of package color saturation on health and taste in consumer judgments
Authors: Kunz Sonja , Haasova Simona , Florack Arnd 
Published: December 2019

AbstractWhen evaluating food products, consumers rely on visual cues on packages to infer their healthiness and tastiness. We assumed that color, specifically color saturation, is one such cue, similarly relevant for both healthiness and tastiness inferences. We conducted three studies in which we manipulated the color of pictures of product packages. Participants viewed pictures from the category of snacks (Study 1a) and drinks (Studies 1b and 2), available at a supermarket's online store and rated each product on the dimensions of healthiness and tastiness. In two studies, we showed one group of participants product pictures only as grayscale images, whereas another group viewed the pictures in full color. In a third study, we showed participants product pictures once with increased and once with decreased color saturation. We consistently found a positive correlation between healthiness and tastiness. Presenting pictures of products as grayscale images weakened the healthy‐tasty correlation. Products with increased compared with decreased color saturation were rated as both healthier and tastier, mediated by the products' perceived freshness.
Emery‐Dreifuss muscular dystrophy
Authors: Heller Scott A. , Shih Renata , Kalra Raghav , Kang Peter B. 
Published: December 2019

AbstractEmery‐Dreifuss muscular dystrophy (EDMD) is a rare muscular dystrophy, but is particularly important to diagnose due to frequent life‐threatening cardiac complications. EDMD classically presents with muscle weakness, early contractures, cardiac conduction abnormalities and cardiomyopathy, although the presence and severity of these manifestations vary by subtype and individual. Associated genes include EMD, LMNA, SYNE1, SYNE2, FHL1, TMEM43, SUN1, SUN2, and TTN, encoding emerin, lamin A/C, nesprin‐1, nesprin‐2, FHL1, LUMA, SUN1, SUN2, and titin, respectively. The Online Mendelian Inheritance in Man database recognizes subtypes 1 through 7, which captures most but not all of the associated genes. Genetic diagnosis is essential whenever available, but traditional diagnostic tools can help steer the evaluation toward EDMD and assist with interpretation of equivocal genetic test results. Management is primarily supportive, but it is important to monitor patients closely, especially for potential cardiac complications. There is a high potential for progress in the treatment of EDMD in the coming years.
Aeroacoustic source term computation based on radial basis functions
Authors: Schoder Stefan , Roppert Klaus , Weitz Michael , Junger Clemens , Kaltenbacher Manfred 
Published: December 2019

SUMMARYIn low Mach number aeroacoustics, the known disparity of length scales makes it possible to apply well‐suited simulation models using different meshes for flow and acoustics. The workflow of these hybrid methodologies include performing an unsteady flow simulation, computing the acoustic sources, and simulating the acoustic field. Therefore, hybrid methods seek for robust and flexible procedures, providing a conservative mesh to mesh interpolation of the sources while ensuring high computational efficiency. We propose a highly specialized radial basis function interpolation for the challenges during hybrid simulations. First, the computationally efficient local radial basis function interpolation in conjunction with a connectivity‐based neighbor search technique is presented. Second, we discuss the computation of spatial derivatives based on radial basis functions. These derivatives are computed in a local‐global approach, using a Gaussian kernel on local point stencils. Third, radial basis function interpolation and derivatives are used to compute complex aeroacoustic source terms. These ingredients are necessary to provide flexible source term calculations that robustly connect flow and acoustics. Finally, the capabilities of the presented approach are shown in a numerical experiment with a co‐rotating vortex pair.
Intramolecular photo‐driven electron transfer in the series of DMABN related compounds with para‐substituted acceptors. Study of the rate constants by Marcus theory
Authors: Volchkov Valery V. , Khimich Mikhail N. , Rusalov Mikhail V. , Gostev Fedor E. , Shelaev Ivan V. , Nadtochenko Viktor A. , Gromov Sergey P. , Melnikov Mikhail Ya. 
Published: December 2019

AbstractA series of DMABN‐related compounds with two‐band fluorescence was studied by steady‐state absorption and fluorescence spectroscopy, time‐resolved absorption spectroscopy upon excitation with a 30‐fs laser pulse, and by TDDFT and xMCQDPT2 quantum chemical methods. The efficiency of the intramolecular electron transfer was found to depend on the excitation wavelength in MeCN. The reaction is described by a two‐state scheme (LE↔CT); the Stevens‐Ban method gives underestimated values for the reaction enthalpy ΔH (SB). The spectral luminescence and kinetic parameters, rate constants, and barriers for the forward (k1, Ea) and reverse (k−1, Ed) electron transfer were calculated. The Marcus plot for k1 versus the driving force (−ΔG) and the total reorganization energy (λ) were calculated for six compounds. It was shown that without a barrier, the 1/k1 value (267 fs) is close to the mean solvation time in MeCN (260 fs), ie, the reaction rate is completely determined by the solvent. The results of conformational analysis for all studied compounds are consistent with the twisted intramolecular charge transfer model of structural relaxation.
Sublethal effects of spirodiclofen on biological and demographic parameters of the citrus leprosis mite Brevipalpus yothersi (Acari: Tenuipalpidae)
Authors: Amaral Ingrid , Melville Cirano C , Rocha Claudiane M , Della Vechia Jaqueline F , Prado Thais J , Andrade Daniel J 
Published: December 2019

AbstractBACKGROUNDBrevipalpus yothersi Baker is one of the main vectors of citrus leprosis. Knowing the biology of this mite species when under chemical control is extremely important to understand its population dynamics, and then to solve problems of management of this pest. Therefore, we assessed the effects of one sublethal dose of spirodiclofen (0.48 ppm) on biological and demographic parameters of B. yothersi under laboratory and greenhouse conditions, comparing them with non‐exposed mite population.RESULTSUnder laboratory conditions, where citrus fruits were used as a substrate, the duration of developmental stages (pre‐egg‐laying and egg‐laying) and mite longevity showed no differences between treatments. However, the number of laid eggs increased in acaricide‐treated fruits. In the greenhouse experiment, where citrus plants were used as a substrate, the instantaneous growth rate (ri) of mites was positive in all untreated plots. In contrast, in treated plants, ri was negative in 12 experimental units, and mite populations were suppressed in five of them. Moreover, mite population dynamics had a positive ri in three treated plants.CONCLUSIONSSpirodiclofen sublethal dose had no negative effect on the offspring of B. yothersi females. However, it is not safe for citrus leprosis mite since it may increase egg number per female in some conditions. Biological and demographic differences could influence mite population dynamics in the field, requiring appropriate management strategies to improve citrus leprosis control. © 2019 Society of Chemical Industry
Relevance of the ecological traits of parasitoid wasps and nectariferous plants for conservation biological control: a hybrid meta‐analysis
Authors: Zhu Pingyang , Zheng Xusong , Xie Gang , Chen Guihua , Lu Zhongxian , Gurr Geoff 
Published: December 2019

AbstractBACKGROUNDEcosystem services are key to human survival. In agriculture, they offer potential to intensify production while reducing reliance on hazardous inputs, including pesticides. Nectar plants can nourish natural enemies of pests and thereby promote the ecosystem service of biological control. To date, however, the selection of optimal plants has been reliant on laborious testing of multiple candidate species for use in each new agroecosystem. We report a hybrid meta‐analysis of published literature, employing Bayesian network analysis.RESULTSThe hybrid meta‐analysis identified the particular plant and parasitoid traits that were most predictive of promoted or suppressed parasitoid longevity. Integrating trait effects identified a combination of plant‐parasitoid traits that had the highest impact on parasitoid longevity: compound umbel or raceme inflorescence form and shallow corolla, together with high potential fecundity of the parasitoid.CONCLUSIONUnlike earlier analyses focusing on taxonomic categories, we analyzed effect sizes in relation to the ecological traits of parasitoids and plants. This generated the first generalizable guidelines for selecting nectar plants as well as appropriate parasitoid targets for the enhancement of biological control. Within the guidelines, optimal outcomes resulted when plants with compound umbel or raceme inflorescences and shallow corollas were combined with fecund parasitoids. More widely, this type of ecological trait‐based meta‐analysis opens a new avenue for optimizing the delivery of other types of ecosystem services. © 2019 Society of Chemical Industry
A generally weighted moving average control chart for zero‐inflated Poisson processes
Authors: Alevizakos Vasileios , Koukouvinos Christos 
Published: December 2019

AbstractZero‐inflated Poisson (ZIP) model is very useful in high‐yield processes where an excessive number of zero observations exist. This model can be viewed as an extension of the standard Poisson distribution. In this paper, a one‐sided generally weighted moving average (GWMA) control chart is proposed for monitoring upward shifts in the two parameters of a ZIP process (regarded as ZIP‐GWMA chart). The design parameters of the proposed chart are provided, and through a simulation study, it is shown that the ZIP‐GWMA performs better than the existing control charts under shifts in both parameters. Moreover, an illustrative example is presented to display the application of the proposed chart on practitioners.
Design of new organic superacids with fused and isolated pyrrole and cyclopentadiene rings and assessment of effect of –BX2(X = H, F, Cl, CN) substituents on the acidity enhancement: A DFT analysis
Authors: Parsazadeh Hasibeh , Valadbeigi Younes , Rouhani Morteza 
Published: December 2019

AbstractNew classes of organic Brønsted acids were designed with pyrrole and cyclopentadiene scaffolds, and their acidity was assessed theoretically by the B3LYP/6‐311++G(d,p) method. The hydrogen atom of NH group in pyrrole was substituted by an –BX2(X = H, F, Cl, CN, CF3). The boron atom stabilizes the conjugated bases by interaction with the center of negative charge after deprotonation. The acidity of the compounds was promoted by substitution of the hydrogen atoms of the rings with CN moiety as a strong electron withdrawing group. Also, after deprotonation, delocalization of the negative charge in both pyrrole and cyclopentadiene rings causes stability of the conjugated bases and consequently enhances the acidity. The charge delocalization in the neutral acids and their conjugated bases was compared using nucleus‐independent chemical shift index. Enthalpies and Gibbs free energies of deprotonation in gas phase, ∆Hacidand ∆Gacid, were used as a measure of acidity. Both compounds with isolated and fused pyrrole and cyclopentadiene rings were investigated and it was found that the formers are more acidic. Using these strategies, several acids and superacids with wide range of acidity with ∆Gacidvalues of 244 to 328 kcal mol−1were obtained.
Off‐road ground robot path energy cost prediction through probabilistic spatial mapping
Authors: Quann Michael , Ojeda Lauro , Smith William , Rizzo Denise , Castanier Matthew , Barton Kira 
Published: December 2019

AbstractEnergy is an important factor in planning for ground robots, particularly in off‐road environments where the terrain significantly impacts energy usage. Unfortunately, energy costs in these environments are variable and uncertain, making planning difficult. In this paper, we present a method, based on Gaussian process regression (GPR) and known vehicle modeling information, for predicting future path energy costs. The method uses data, collected by a robot operating in a 3D environment with varying terrains, to build a map from inputs (including position, heading, slope, and satellite imagery) to power consumption. The energy costs of future paths are predicted through the summation of power predictions. Importantly, correlations in those predictions are considered to avoid overconfidence. Experimental cross‐validation results demonstrate improved accuracy of path energy cost predictions against a baseline approach, as well as the effect of Gaussian process inputs and kernel choice. Additionally, we show how vehicle modeling can aid in predicting energy costs, particularly when data on the environment is sparse.
The influence of fibroblast growth factor 2 on the senescence of human adipose-derived mesenchymal stem cells during long-term culture
Authors: Cheng Yin , Lin Kai-Hsuan , Young Tai-Horng , Cheng Nai-Chen 
Published: December 2019

Abstract
Adipose-derived mesenchymal stem cells (ASCs) exhibit great potential in regenerative medicine, and in vitro expansion is frequently necessary to obtain a sufficient number of ASCs for clinical use. Fibroblast growth factor 2 (FGF2) is a common supplement in the ASC culture medium to enhance cell proliferation. To achieve clinical applicability of ASC-based products, prolonged culture of ASCs is sometimes required to obtain sufficient quantity of ASCs. However, the effect of FGF2 on ASCs during prolonged culture has not been previously determined. In this study, ASCs were subjected to prolonged in vitro culture with or without FGF2. FGF2 maintained the small cell morphology and expedited proliferation kinetics in early ASC passages. After prolonged in vitro expansion, FGF2-treated ASCs exhibited increased cell size, arrested cell proliferation, and increased cellular senescence relative to the control ASCs. We observed an upregulation of FGFR1c and enhanced expression of downstream STAT3 in the initial passages of FGF2-treated ASCs. The application of an FGFR1 or STAT3 inhibitor effectively blocked the enhanced proliferation of ASCs induced by FGF2 treatment. FGFR1c upregulation and enhanced STAT3 expression were lost in the later passages of FGF2-treated ASCs, suggesting that the continuous stimulation of FGF2 becomes ineffective because of the refractory downstream FGFR1 and the STAT3 signaling pathway. In addition, no evidence of tumorigenicity was noted in vitro and in vivo after prolonged expansion of FGF2-cultured ASCs. Our data indicate that ASCs have evolved a STAT3-dependent response to continuous FGF2 stimulation which promotes the initial expansion but limits their long-term proliferation.

Significance statement Adipose-derived mesenchymal stem cell (ASC) is a valuable cell source for regenerative medicine, and prolonged cell expansion may be desired to develop ASC-based products. Fibroblast growth factor 2 (FGF2) is a common supplement in the culture medium to enhance ASC proliferation. However, the effect of FGF2 on the ASC aging process during prolonged culture has not been well studied. This study found that although FGF2 maintains cellular morphology and enhances cell proliferation in the early passages of ASC culture, continuous FGF2 supplement exerts adverse effects on the late passages. The information is important for large-scale ASC production for clinical use.
Stem cell-derived retinal pigment epithelium from patients with age-related macular degeneration exhibit reduced metabolism and matrix interactions
Authors: Gong Jie , Cai Hui ,   NYSCF Global Stem Cell Array Team, Noggle Scott , Paull Daniel , Rizzolo Lawrence J. , Del Priore Lucian V. , Fields Mark A. 
Published: December 2019

Abstract
Modeling age-related macular degeneration (AMD) is challenging, because it is a multifactorial disease. To focus on interactions between the retinal pigment epithelium (RPE) and Bruch's membrane, we generated RPE from AMD patients and used an altered extracellular matrix (ECM) that models aged Bruch's membrane. Induced pluripotent stem cells (iPSCs) were generated from fibroblasts isolated from AMD patients or age-matched (normal) controls. RPE derived from iPSCs were analyzed by morphology, marker expression, transepithelial electrical resistance (TER), and phagocytosis of rod photoreceptor outer segments. Cell attachment and viability was tested on nitrite-modified ECM, a typical modification of aged Bruch's membrane. DNA microarrays with hierarchical clustering and analysis of mitochondrial function were used to elucidate possible mechanisms for the observed phenotypes. Differentiated RPE displayed cell-specific morphology and markers. The TER and phagocytic capacity were similar among iPSC-derived RPE cultures. However, distinct clusters were found for the transcriptomes of AMD and control iPSC-derived RPE. AMD-derived iPSC-RPE downregulated genes responsible for metabolic-related pathways and cell attachment. AMD-derived iPSC-RPE exhibited reduced mitochondrial respiration and ability to attach and survive on nitrite-modified ECM. Cells that did attach induced the expression of complement genes. Despite reprogramming, iPSC derived from AMD patients yielded RPE with a transcriptome that is distinct from that of age-matched controls. When challenged with an AMD-like modification of Bruch's membrane, AMD-derived iPSC-RPE activated the complement immune system.

Significance statement Age-related macular degeneration (AMD) is a multifactorial disease of primates, which confounds efforts to model the disease in laboratory animals or in culture. The present culture model mimics aspects of the disease, as demonstrated by using stem cells derived from patients. The disease involves interactions between the retinal pigment epithelium, a layer of cells necessary for the function of photoreceptors, and the extracellular matrix upon which the epithelium sits. The differences observed between epithelia derived from normal and AMD patients were exacerbated when cells were cultured on a mimetic for diseased matrix. This model provides a robust platform for developing therapeutics.