bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of blended instructional design based on active learning in a graphic engineering course
Authors: Olmedo‐Torre Noelia , Martínez María Martínez , Peña Marta 
Published: September 2020

AbstractEncouraging the use of active‐learning methodologies, both inside and outside the classroom by means of planned activities, is a key factor in effective learning, as well as being essential for students to achieve the goals set for each subject by making them responsible for their own learning. In this longitudinal and quantitative study, we describe the different active learning activities, such as Flipped Classroom, Design Thinking, Visual Thinking, and Project‐Based Learning (PBL), undertaken from 2015 to 2018 in the compulsory subject Graphic Expression imparted during the first year from all the degree studies of the Escola d'Enginyeria de Barcelona Est from Universitat Politècnica de Catalunya—UPC BarcelonaTech. The introduction of active‐learning teaching methodologies for the solving of problems with computer aided design throughout the course, with increasing complexity of exercise completion, has led to a significant improvement in academic results by students in this subject. The results show that the inclusion of these methodologies improves student learning, as seen through the group development of an engineering project presented on the conclusion of the course. PBL is the methodology that is most highly appreciated by students because it enables them to integrate all the skills and knowledge acquired throughout the course and is also the activity in which they obtain the best marks.
Chemical Translational Biology‐Guided Molecular Diagnostics: The Front Line To Mediate the Current SARS‐CoV‐2 Pandemic
Authors: Dai Yifan 
Published: September 2020

AbstractThe spread of severe respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has disrupted our global society in unprecedented ways. The very front line in defense against this pandemic is molecular diagnosis, which is an exceptional representation of how chemical translational biology can benefit our lives. In this viewpoint, I emphasize the imperative demand for a simple and rapid point‐of‐care system in order to mediate the spread of COVID‐19. I further describe how the interdisciplinary combination of chemistry and biology advances biosensing systems, which potentially lead to integrated and automated point‐of‐care systems capable of relieving the current pandemic.
Primary spinal epidural non‐Hodgkin's diffuse large B‐cell lymphoma: A case report
Authors: Pokhrel Nishan Babu , Prasad Rohit , Paudel Sushil , Kafle Dinesh , Pokharel Rohit Kumar 
Published: September 2020

AbstractRare disease like primary spinal epidural diffuse large B‐cell lymphoma should be considered as a differential diagnosis in patients presenting with back pain and rapid neurological deterioration in the lower extremities.
Giant coronary artery aneurysm in infantile Kawasaki disease: When to use cardiac computed tomography angiography
Authors: Kadakia Shreeja , Do‐Nguyen Chi Chi , Kilcoyne Maxwell F. , Stevens Randy M. , Lindholm Erika , Nanassy Autumn , Starc James , Mallon Mary G. 
Published: September 2020

AbstractTransthoracic echocardiography is the imaging modality of choice for the detection of coronary artery aneurysms (CAAs) in Kawasaki disease. However, cardiac computed tomography angiography is useful in the diagnosis of distal CAAs.
Innovative Multipodal Ligands Derived from Tröger's Bases for the Sensitization of Lanthanide(III) Luminescence
Authors: Trupp Leandro , Bruttomesso Andrea C. , Vardé Mariana , Eliseeva Svetlana V. , Ramírez Javier A. , Petoud Stéphane , Barja Beatriz C. 
Published: September 2020

AbstractHerein, the synthesis and characterization of the first family of multipodal ligands with a Tröger's base framework designed for the preparation of luminescent lanthanide(III) complexes are reported. Eight ligands were designed and synthesized using different strategies, including alkylation reactions, amide couplings, and Ugi multicomponent reactions. All the ligands bear carboxylate groups for the coordination of the lanthanide(III) ions, with the lanthanide(III)‐sensitizing units consisting of the Tröger's base framework itself or attached benzamides. Upon irradiation of the chromophoric ligands, green terbium(III) emission was efficiently generated, whereas europium(III) emission was negligible. The geometry and substitution pattern of the ligands allow control of the stoichiometry of the species formed and the TbIII luminescence sensitization efficiency, showing that para‐substitution patterns are more efficient than meta substitution for the formation of coordination compounds with lower TbIII/ligand ratio. We propose that the species formed are self‐assembled 2:2 or 2:4 metallosupramolecular structures.
Copper‐Catalyzed Addition of Grignard Reagents to in situ Generated Indole‐Derived Vinylogous Imines
Authors: Ge Luo , Zurro Mercedes , Harutyunyan Syuzanna R. 
Published: September 2020

AbstractChiral indole derivatives are ubiquitous motifs in pharmaceuticals and alkaloids. Herein, the first protocol for catalytic asymmetric conjugate addition of Grignard reagents to various sulfonyl indoles, offering a straightforward approach for the synthesis of chiral 3‐sec‐alkyl‐substituted indoles in high yields and enantiomeric ratios is presented. This methodology makes use of a chiral catalyst based on copper phosphoramidite complexes and in situ formation of vinylogous imine intermediates.
Prognostic value of brain natriuretic peptide vs history of heart failure hospitalization in a large real‐world population
Authors: Zile Michael R. , Desai Akshay S. , Agarwal Rahul , Bharmi Rupinder , Dalal Nirav , Adamson Philip B. , Maisel Alan S. 
Published: September 2020

AbstractBackgroundIn heart failure (HF) patients, both natriuretic peptides (NP) and previous HF hospitalization (pHFH) have been used to predict prognosis.HypothesisIn a large real‐world population, both NP levels and pHFH have independent and interdependent predictive value for clinical outcomes of HFH and all‐cause mortality.MethodsLinked electronic health records and insurance claims data from Decision Resource Group were used to identify HF patients that had a BNP or NT‐proBNP result between January 2012 and December 2016. NT‐proBNP was converted into BNP equivalents by dividing by 4. Index event was defined as most recent NP on or after 1 January 2012. Patients with incomplete records or age < 18 years were excluded. During one‐year follow up, HFH and mortality rates stratified by index BNP levels and pHFH are reported.ResultsOf 64 355 patients (74 ± 12 years old, 49% female) with available values, median BNP was 259 [IQR 101‐642] pg/ml. The risk of both HFH and mortality was higher with increasing BNP levels. At each level of BNP, mortality was only slightly higher in patients with pHFH vs those without pHFH (RR 1.2 [95%CI 1.2,1.3], P < .001); however, at each BNP, HFH was markedly increased in patients with pHFH vs those without pHFH (RR 2.0 [95%CI 1.9,2.1], P < .001).ConclusionIn this large real‐world heart failure population, higher BNP levels were associated with increased risk for both HFH and mortality. At any given level of BNP, pHFH added greater prognostic value for prediction of future HFH than for mortality.
Judicious data management for sustaining an energy harvesting sensor node
Authors: Singh Kaumudi , Shukla Pratyush , S. M. Sachin , Gnani Nithish K. , T. V. Prabhakar , Kuri Joy 
Published: September 2020

SummaryPerpetual lifetimes and low maintenance are few of the attractive aspects of sensor nodes that harvest ambient energy. However, their operation depends heavily on the energy profiles of their harvesting source(s). In this work, we study the suitability of energy harvesting sensor (EHS) Nodes, powered using indoor lighting and vibrations, for a simple temperature monitoring application. To help these nodes sustain, we have proposed schemes that allow the nodes to sample and transmit data judiciously. Along with an adaptive sampling based on autoregressive (AR) model, we have proposed a regulating function based transmission scheme that regulates the amount of transmitted data based on the energy available at the node and the characteristics of the data so that even with limited transmissions the fidelity of the data is not lost. With the help of thorough evaluations, we can conclude that an EHS node fares quite well. Results show that adaptive sampling and transmissions based on regulating function not only save energy at the sensor nodes, but they also reduce the amount of data generated and accumulated in a network.
Static Detection of File Access Control Vulnerabilities on Windows System
Authors: Lu Jiadong , Gu Fangming , Wang Yiqi , Chen Jiahui , Peng Zhiniang , Wen Sheng 
Published: September 2020

SummaryTraditional applications have been developed for decades. Most of the security research around them have focused on the detection of memory corruption vulnerabilities, such as buffer overflow, double fetch, and integer overflow. On the contrary, logic bugs, a kind of flaws caused by unreasonable application logic, attract much less attention.Files are the most common media for programs to persist their data in the system. As the file owners, programs are responsible for protecting their files from malicious users' tampering by leveraging access control mechanisms. However, if a program configures their access control mechanisms in wrong ways and causes evil users to bypass security checks to access files, there exists a file access control vulnerability. As a branch of logic flaws, file access control vulnerabilities are less popular with researchers. Thus, to mitigate the harm of the file access control vulnerabilities on Windows system, our team conducted first‐step research on them. We first classified file access control bugs into two types and codified some bug patterns. Then we formalized file access control vulnerabilities to propose a scalable detection method and implemented a lightweight analysis system StaticFAC. After evaluating StaticFAC in real‐world Windows software, we discovered 15 0‐day bugs.
An accurate and efficient two‐phase scheme for detecting Android cloned applications
Authors: Xie Jiahao , Yan Xiai , Lin Yaping , Wei Jianhao 
Published: September 2020

SummaryThe fast‐growing Android application market has attracted more and more application developers. However, many plagiarists use decompiled tools to modify original applications to get clones, which has become a serious threat. For detecting cloned applications, most of the existing schemes do not consider the detected accuracy and time consumption at the same time. In this article, we propose a two‐phase detection scheme to achieve fast and accurate clone detection in large‐scale applications. In the rapid screening phase, a fix‐length minhash summary is constructed for each application and the locality‐sensitive hashing (LSH) algorithm is used to obtain suspicious cloned applications quickly. In the accurate detection phase, by merging and pruning the layout and interaction information of all user interfaces (UIs) at the application runtime, we obtain the birthmark named merged layout tree (MLT), which can resist nested obfuscation and repacking attack. Finally, cloned apps are detected by calculating the similarity between MLTs from suspicious cloned apps. We evaluate our detection scheme in two app datasets (nearly 170,000 Android applications) and compare it with the state‐of‐the‐art clone detection methods. Extensive experiments show that our method has high accuracy and efficiency for clone detection in large‐scale apps.
Correlated data in differential privacy: Definition and analysis
Authors: Zhang Tao , Zhu Tianqing , Liu Renping , Zhou Wanlei 
Published: September 2020

SummaryDifferential privacy is a rigorous mathematical framework for evaluating and protecting data privacy. In most existing studies, there is a vulnerable assumption that records in a dataset are independent when differential privacy is applied. However, in real‐world datasets, records are likely to be correlated, which may lead to unexpected data leakage. In this survey, we investigate the issue of privacy loss due to data correlation under differential privacy models. Roughly, we classify existing literature into three lines: (1) using parameters to describe data correlation in differential privacy, (2) using models to describe data correlation in differential privacy, and (3) describing data correlation based on the framework of Pufferfish. First, a detailed example is given to illustrate the issue of privacy leakage on correlated data in real scenes. Then our main work is to analyze and compare these methods, and evaluate situations that these diverse studies are applied. Finally, we propose some future challenges on correlated differential privacy.
On the Interaction between Deprotonated Cytosine [C(−H)]− and Ba2+: Infrared Multiphoton Spectroscopy and Dynamics
Authors: Cruz‐Ortiz Andrés F. , Taccone Martín I. , Maitre Philippe , Rossa Maximiliano , Pino Gustavo A. 
Published: September 2020

AbstractGas‐phase interactions between Ba2+ and deprotonated cytosine (C(−H)) were studied in [C(−H)Ba]+ and [C(−H)BaC]+ complexes by IRMPD spectroscopy coupled to tandem mass‐spectrometry in combination with DFT calculations. For the [C(−H)BaC]+ complex only one [C(−H)KAN1O−Ba‐Canti]+ isomer was found, although the presence of another structure cannot be excluded. This isomer features a central tetracoordinated Ba2+ that simultaneously interacts with keto‐amino [C(−H)]− deprotonated on N1 and neutral keto‐amino C. Both moieties are in different planes as a consequence of an additional NH…O=C hydrogen bond between C and [C(−H)]−. A sequential IRMPD dynamics is observed in this complex. For the [C(−H)Ba]+ complex produced by electrospray ionization two isomers ([C(−H)KAN1OBa]+ and [C(−H)KAN3OBa]+) were identified, in which Ba2+ interacts simultaneously with the C=O group and the N1 or N3 atom of the keto‐amino [C(−H)]−, respectively. A comparison with the related [C(−H)Pb]+ complex (J. Y. Salpin et al., Chem. Phys. Chem. 2014, 15, 2959–2971) is also presented.
The Mediterranean diet increases glucagon‐like peptide 1 and oxyntomodulin compared with a vegetarian diet in patients with type 2 diabetes: A randomized controlled cross‐over trial
Authors: Di Mauro Antonio , Tuccinardi Dario , Watanabe Mikiko , Del Toro Rossella , Monte Lavinia , Giorgino Riccardo , Rampa Lorenzo , Rossini Giovanni , Kyanvash Shadi , Soare Andreea , Rosati Milena , Piccoli Alessandra , Napoli Nicoli , Fioriti Elvira , Pozzilli Paolo , Khazrai Yeganeh M. , Manfrini Silvia 
Published: September 2020

AbstractAimTo compare a Mediterranean diet (MED) with a high‐fibre vegetarian diet (HFV) in terms of hunger‐satiety perception through post‐prandial assessment of appetite‐related hormones glucagon‐like peptide 1 (GLP‐1) and oxyntomodulin, as well as self‐rated visual analogue scale (VAS) quantification, in overweight/obese subjects with type 2 diabetes (T2D).Materials and methodsTwelve T2D subjects (Male to female ratio = 7:5), mean age 63 ± 8.5 years, were enrolled in a randomized, controlled, crossover study. Participants consumed an MED meal as well as an isocaloric meal rich in complex carbohydrate as well as an isocaloric MED meal in two different visits with a 1‐week washout period between the two visits. Appetite ratings, glucose/insulin, and gastrointestinal hormone concentrations were measured at fasting and every 30’ until 210’ following meal consumption.ResultsGLP‐1 and oxyntomodulin levels were significantly higher following MED meal compared with HFV meals (210’ area under the curve, p < 0.022 and p < 0.023, respectively). Both MED and HFV meal resulted in a biphasic pattern of GLP‐1 and oxyntomodulin, although MED meal was related to a delayed, significantly higher second GLP‐1 peak at 150’ compared with that of HFV meal (p < 0.05). MED meal was related to lower glucose profile compared with HFV meal (p < 0.039), whereas we did not observe significant changes in terms of self‐reported VAS scores and insulin trend.ConclusionsIn T2D overweight/obese subjects, an MED meal is more effective than a HFV meal in terms of post‐prandial plasma glucose homoeostasis and GLP‐1 and oxyntomodulin release. These changes were not confirmed by VAS appetite self‐assessment over a 210’ period.
Quantification of direct‐acting oral anticoagulants: Application of a clinically validated liquid chromatography‐tandem mass spectrometry method to forensic cases
Authors: Wiesen Martin H.J. , Fietz Cornelia , Jübner Martin , Iwersen‐Bergmann Stefanie , Andresen‐Streichert Hilke , Müller Carsten , Streichert Thomas 
Published: September 2020

AbstractIn certain forensic cases, a quantification of direct‐acting oral anticoagulants (DOACs) can be necessary. We evaluate the applicability of a previously described liquid chromatography–tandem mass spectrometry (LC‐MS/MS) methodology for the determination of DOACs in plasma to postmortem specimen. Postmortem internal quality control (PIQC) samples were prepared in pooled blank postmortem heart blood, femoral blood, cerebrospinal fluid (CSF), and urine as well in plasma. To examine the application of the clinical method to forensic cases, the main validation parameters were reinvestigated using PIQC samples. Postmortem samples of 12 forensic cases with evidence of previous rivaroxaban intake and unknown bleeding disorders were analyzed. Interday variability remained within the acceptance criterion of ±15%. Matrix effects were comparable in blank plasma and postmortem matrix extracts. After 4 weeks of storage in the refrigerator, no relevant decrease of DOACs was evident. After 96 h of storage at room temperature, a slight decrease in edoxaban concentration was observed in CSF and urine, while plasma edoxaban decreased by about 50%. Median (range) rivaroxaban concentrations determined in specimen of forensic cases were as follows: heart blood (n = 6), 17.2 ng/ml (<LOQ, 56.6 ng/ml); femoral blood (n = 12), 27.6 ng/ml (<LOQ, 110.5 ng/ml); CSF (n = 7), 11.7 ng/ml (<LOQ, 17.5 ng/ml); urine (n = 6), 275.7 ng/ml (14.5–870.9 ng/ml). The median heart/femoral blood rivaroxaban ratio was 1.2 (n = 5). Exemplary, a forensic case with detection of edoxaban in femoral blood, CSF, and urine, is presented. DOACs can be detected in postmortem heart and femoral blood, CSF, and urine specimen by LC‐MS/MS. Based on limited forensic cases, no significant redistribution was evident for rivaroxaban, which was found at highest concentrations in urine.
A stochastic model of jaguar abundance in the Peruvian Amazon under climate variation scenarios
Authors: Burrage Kevin , Burrage Pamela , Davis Jacqueline , Bednarz Tomasz , Kim June , Vercelloni Julie , Peterson Erin E. , Mengersen Kerrie 
Published: September 2020

AbstractThe jaguar (Panthera onca) is the dominant predator in Central and South America, but is now considered near‐threatened. Estimating jaguar population size is difficult, due to uncertainty in the underlying dynamical processes as well as highly variable and sparse data. We develop a stochastic temporal model of jaguar abundance in the Peruvian Amazon, taking into account prey availability, under various climate change scenarios. The model is calibrated against existing data sets and an elicitation study in Pacaya Samiria. In order to account for uncertainty and variability, we construct a population of models over four key parameters, namely three scaling parameters for aquatic, small land, and large land animals and a hunting index. We then use this population of models to construct probabilistic evaluations of jaguar populations under various climate change scenarios characterized by increasingly severe flood and drought events and discuss the implications on jaguar numbers. Results imply that jaguar populations exhibit some robustness to extreme drought and flood, but that repeated exposure to these events over short periods can result in rapid decline. However, jaguar numbers could return to stability—albeit at lower numbers—if there are periods of benign climate patterns and other relevant factors are conducive.
Will shrinking body size and increasing species diversity of crustaceans follow the warming of the Arctic littoral?
Authors: Węsławski Jan M. , Legeżyńska Joanna , Włodarska‐Kowalczuk Maria 
Published: September 2020

AbstractOver thirty species of littoral marine Gammaridea occur along the coasts of the North Atlantic. From one to several species can coexist in a single region. There is an evident, inverse relationship between egg incubation time and temperature (from 14 to >120 days) and consequent trends in the size of the animals on reaching maturity (from 5 mm in warmer waters to 30 mm in the coldest ones) and in lifespan (from <6 months to >5 years). Littoral gammarids are a good example of the shrinking size effect of increasing temperatures and size‐related species diversity. In large species, the annual cohorts of the population (3–5 annual size groups) functionally replace the adults of smaller species. The ongoing warming of the European Arctic seas may extend the distribution limits of boreal species so that more Gammarus species may appear on northern coasts hitherto occupied by just one or at most two species.
Non‐invasive telemonitoring improves outcomes in heart failure with reduced ejection fraction: a study in high‐risk patients
Authors: Nunes‐Ferreira Afonso , Agostinho João R. , Rigueira Joana , Aguiar‐Ricardo Inês , Guimarães Tatiana , Santos Rafael , Rodrigues Tiago , Cunha Nelson , António Pedro Silvério , Pereira Sara Couto , Morais Pedro , Pedro Mónica Mendes , Veiga Fátima , Pinto Fausto J. , Brito Dulce 
Published: September 2020

AbstractAimsNon‐invasive telemonitoring (TM) in patients with heart failure (HF) and reduced left ventricular ejection fraction (HFrEF) may be useful in the early diagnosis of HF decompensation, allowing therapeutic optimization and avoiding re‐hospitalization. We describe a TM programme in this population and evaluate its effectiveness during a 12 month period.Methods and resultsWe conducted a single‐centre study of patients discharged from hospital after decompensated HF, allocated into three groups: prospective TM programme, prospective HF protocol follow‐up programme (PFP) with no TM facilities, and retrospective propensity‐matched usual care (UC). TM effectiveness was assessed by all‐cause hospitalizations and mortality; HF‐related hospitalization (HFH), days lost to unplanned hospital admissions/death, functional capacity and quality of life (New York Heart Association, Kansas City Cardiomyopathy Questionnaire, 6 min walk test, and plasma N‐terminal pro‐brain natriuretic peptide) were also evaluated. A total of 125 patients were included [65.9 ± 11.9 years, 32% female, left ventricular ejection fraction 27% (21–32)]. TM was similar to PFP regarding effectiveness; TM reduced all‐cause hospitalization and mortality (HR 0.27; 95% CI 0.11–0.71; P < 0.01) and HFH (HR 0.29; 95% CI 0.10–0.89; P < 0.05) as compared with UC. TM reduced the average number of days lost due to unplanned hospital admissions or all‐cause death as compared with PFP (5.6 vs. 12.4 days, P < 0.05) and UC (5.6 vs. 48.8 days, P < 0.01). Impact on quality of life was similar between TM and PFP (P = 0.36).ConclusionsIn patients with HFrEF and recent HF hospitalization, non‐invasive TM reduced 12 month all‐cause hospitalization/mortality and HFH as compared with usual care. TM also reduced the number of days lost due to unplanned hospital admission/death as compared with either an optimized protocol‐based follow‐up programme or usual care.