bluuebunny/crossref_metadata_2025_split huggingface dataset:
Confinement Effect Driven Quantum Spin Hall Effect in Monolayer AuTe2Cl
Authors: Zhong Guyue , Xie Q. , Xu Gang 
Published: December 2019

Based on first-principles calculations, we predict that the monolayer AuTe2Cl is a quantum spin Hall (QSH) insulator with a topological band gap about 10 meV. The three-dimensional (3D) AuTe2Cl is a topological semimetal that can be viewed as the monolayer stacking along [Formula: see text] axis. By studying the energy-level distribution of [Formula: see text] orbitals of Te atoms for the bulk and the monolayer, we find that the confinement effect driven [Formula: see text] band inversion is responsible for the topological nontrivial nature of monolayer. Since 3D bulk AuTe2Cl has already been experimentally synthesized, we expect that monolayer AuTe2Cl can be exfoliated from a bulk sample and the predicted QSH effect can be observed.
The Road to High-Temperature Quantum Anomalous Hall Effect in Magnetic Topological Insulators
Authors: He Ke , Xue Qi-Kun 
Published: December 2019

Elevating the temperature needed to realize the quantum anomalous Hall effect (QAHE) to above 77 K or higher is the key to practical applications of the effect as well as many others based on it. Here, we briefly review the recent progresses, especially the experimental ones, on searching for magnetic topological insulators that can exhibit the QAHE at higher temperature. Based on our understanding of these results, we will give the principles and roadmap for designing and constructing high-temperature quantum anomalous Hall systems.
Optical Design of COLIBRÍ: A Fast Follow-up Telescope for Transient Events
Authors: Fuentes-Fernández J. , Watson A. M. , Cuevas S. , Basa S. , Floriot J. , Dolon F. , Valentin H. , Challita Z. , Vola P. 
Published: December 2019

COLIBRÍ will be a Franco-Mexican 1.3-m telescope and imager for observing the visible and near infrared counterparts of transient events detected by the future SVOM mission. The imager is divided into two instruments: DDRAGO, with two 4k[Formula: see text][Formula: see text][Formula: see text]4k CCDs observing in [Formula: see text] and [Formula: see text], respectively, and CAGIRE, with one 2k[Formula: see text][Formula: see text][Formula: see text]2k LYNRED or H2RG detector observing in [Formula: see text]. DDRAGO will directly image the telescope focal plane with a field of view (FoV) of 26[Formula: see text][Formula: see text][Formula: see text]26 arcmin. CAGIRE will reimage the focal plane to make a pupil image available for a cold stop and adjust the plate scale to deliver a similar FoV. CAGIRE will not use a conventional collimator-camera configuration but rather an arrangement of lenses that sends the pupil image close to the focal plane after all of the reimaging optics. This allows most of the optics, including the infrared filters, to be at ambient temperature and avoids the complexity of having mechanisms and powered optics within the cryostat (CR). We present here the optical design of the system and a thorough analysis on the expected image quality of the instruments and the telescope.
β3-Adrenergic receptor blockade reduces mortality in endotoxin-induced heart failure by suppressing induced nitric oxide synthase and saving cardiac metabolism
Authors: Kawaguchi Satoshi , Okada Motoi , Ijiri Eriko , Koga Daisuke , Watanabe Tsuyoshi , Hayashi Kentaro , Kashiwagi Yuta , Fujita Satoshi , Hasebe Naoyuki 
Published: December 2019

The β3-adrenergic receptor (β3AR) is related to myocardial fatty acid metabolism and its expression has been implicated in heart failure. In this study, we investigated the role of β3AR in sepsis-related myocardial dysfunction using lipopolysaccharide (LPS)-induced endotoxemia as a model of cardiac dysfunction. We placed mice into three treatment groups and treated each with intraperitoneal injections of the β3AR agonist CL316243 (CL group), the β3AR antagonist SR59230A (SR group), or normal saline (NS group). Survival rates were significantly improved in the SR group compared with the other treatment groups. Echocardiography analyses revealed cardiac dysfunction within 6–12 h of LPS injections, but the outcome was significantly better for the SR group. Myocardial ATP was preserved in the SR group but was decreased in the CL-treated mice. Additionally, quantitative PCR analysis revealed that expression levels of genes associated with fatty acid oxidation and glucose metabolism were significantly higher in the SR group. Furthermore, the expression levels of mitochondrial membrane protein complexes were preserved in the SR group. Electron microscope studies showed significant accumulation of lipid droplets in the CL group. Moreover, inducible nitric oxide synthase (iNOS) protein expression and nitric oxide were significantly reduced in the SR group. The in vitro study demonstrated that β3AR has an independent iNOS pathway that does not go through the nuclear factor-κB pathway. These results suggest that blockading β3AR improves impaired energy metabolism in myocardial tissues by suppressing iNOS expression and recovers cardiac function in animals with endotoxin-induced heart failure. NEW & NOTEWORTHY Nitric oxide production through stimulation of β3-adrenergic receptor (β3AR) may improve cardiac function in cases of chronic heart failure. We demonstrated that the blockade of β3AR improved mortality and cardiac function in endotoxin-induced heart failure. We also determined that LPS-induced inducible nitric oxide synthase has a pathway that is independent of nuclear factor-κB, which worsened cardiac metabolism and mortality in the acute phase of sepsis. Treatment with the β3AR antagonist had a favorable effect. Thus, the blockade of β3AR could offer a novel treatment for sepsis-related heart failure.
Krogh’s capillary recruitment hypothesis, 100 years on: Is the opening of previously closed capillaries necessary to ensure muscle oxygenation during exercise?
Authors: Angleys Hugo , Østergaard Leif 
Published: December 2019

In 1919, August Krogh published his seminal work on skeletal muscle oxygenation. Krogh’s observations indicated that muscle capillary diameter is actively regulated, rather than a passive result of arterial blood flow regulation. Indeed, combining a mathematical model with the number of ink-filled capillaries he observed in muscle cross sections taken at different workloads, Krogh was able to account for muscle tissue’s remarkably efficient oxygen extraction during exercise in terms of passive diffusion from nearby capillaries. Krogh was awarded the 1920 Nobel Prize for his account of muscle oxygenation. Today, his observations are engrained in the notion of capillary recruitment: the opening of previously closed capillaries. While the binary distinction between “closed” and “open” was key to Krogh’s model argument, he did in fact report a continuum of capillary diameters, degrees of erythrocyte deformation, and perfusion states. Indeed, modern observations question the presence of closed muscle capillaries. We therefore examined whether changes in capillary flow patterns and hematocrit among open capillaries can account for oxygen extraction in muscle across orders-of-magnitude changes in blood flow. Our four-compartment model of oxygen extraction in muscle confirms this notion and provides a framework for quantifying the impact of changes in microvascular function on muscle oxygenation in health and disease. Our results underscore the importance of capillary function for oxygen extraction in muscle tissue as first proposed by Krogh. While Krogh’s model calculations still hold, our model predictions support that capillary recruitment can be viewed in the context of continuous, rather than binary, erythrocyte distributions among capillaries.NEW & NOTEWORTHY Oxygen extraction in working muscle is extremely efficient in view of single capillaries properties. The underlying mechanisms have been widely debated. Here, we develop a four-compartment model to quantify the influence of each of the hypothesized mechanisms on muscle oxygenation. Our results show that changes in capillary flow pattern and hematocrit can account for the high oxygen extraction observed in working muscle, while capillary recruitment is not required to account for these extraction properties.
Exacerbated pressor and sympathoexcitatory effects of central Elabela in spontaneously hypertensive rats
Authors: Geng Zhi , Ye Chao , Tong Ying , Zhang Feng , Zhou Ye-Bo , Xiong Xiao-Qing 
Published: December 2019

Elabela (ELA) is a newly discovered peptide that acts as a novel endogenous ligand of angiotensin receptor-like 1 (APJ) receptor. This study was designed to evaluate the effects of ELA-21 in paraventricular nucleus (PVN) on blood pressure and sympathetic nerve activity in spontaneously hypertensive rats (SHR). Experiments were performed in male Wistar-Kyoto rats (WKY) and SHR. ELA expression was upregulated in PVN of SHR. PVN microinjection of ELA-21 increased renal sympathetic nerve activity (RSNA), mean arterial pressure (MAP), heart rate (HR), plasma norepinephrine, and arginine vasopressin (AVP) levels in SHR. Intravenous injection of ELA-21 significantly decreased MAP and HR in both WKY and SHR, but only induced a slight decrease in RSNA. APJ antagonist F13A in PVN abolished the effects of ELA-21 on RSNA, MAP and HR. Intravenous infusion of both ganglionic blocker hexamethonium and AVP V1a receptor antagonist SR49059 caused significant reduction in the effects of ELA-21 on RSNA, MAP and HR in SHR, while combined administration of hexamethonium and SR49059 abolished the effects of ELA-21. ELA-21 microinjection stimulated Akt and p85α subunit of phosphatidylinositol 3-kinase (PI3K) phosphorylation in PVN, whereas PI3K inhibitor LY294002 or Akt inhibitor MK-2206 almost abolished the effects of ELA-21 on RSNA, MAP, and HR. Chronic PVN infusion of ELA-21 induced sympathetic activation, hypertension, and AVP release accompanied with cardiovascular remodeling in normotensive WKY. In conclusion, ELA-21 in PVN induces exacerbated pressor and sympathoexcitatory effects in hypertensive rats via PI3K-Akt pathway. NEW & NOTEWORTHY We demonstrated that PVN microinjection of ELA-21 increases sympathetic nerve activity and blood pressure, which can be abolished by pretreatment of APJ antagonist. This is the first demonstration that central ELA can induce hypertension. The pressor effects in PVN are mediated by both sympathetic activation and vasopressin release via PI3K-Akt pathway. Our data confirm that ELA is upregulated in the PVN of SHR and so may be involved in the pressor and sympathoexcitatory effects in hypertension.
СИНДРОМ ЕМОЦІЙНОГО ВИГОРАННЯ СЕРЕД МЕДИЧНИХ ПРАЦІВНИКІВ
Authors: Kosa T. V. 
Published: December 2019

У статті проаналізовано проблеми емоційного вигорання серед медичних працівників. Для повсякденної діяльності медичних працівників характерним є високий рівень стресу, який вони відчувають доволі часто. Актуальність проблеми емоційного вигорання видно з наукових публікацій і досліджень, які значно зросли за останнє десятиріччя.
Effects of a diabetes education intervention on diabetes-related factors among Mexican-origin Hispanics
Authors: Moyeda-Carabaza Ana Florencia , Murimi Mary W , Dawson John A , Carrales-Bruno Fabiola 
Published: December 2019

Purpose: The purpose of this study was to assess diabetes-related factors, such as diabetes knowledge, positive attitudes towards the prevention of diabetes and its complications, self-efficacy for diabetes, dietary intake and level of food security, and to investigate the effects of a diabetes education intervention (DEI) on diabetes-related factors among Mexican-origin Hispanics with or without diabetes in Lubbock, Texas (USA), and Piedras Negras, Coahuila (Mexico). Methods: A one-sample pre–post design was used to evaluate the effect of a 4-week DEI designed using the Nutrition Education DESIGN Procedure, Mexican cultural features and Spanish language. Results: Participants from Piedras Negras, Coahuila had higher rates of food insecurity and a higher consumption of whole grains than those from Lubbock, Texas, while participants from Lubbock, Texas, had higher levels of diabetes knowledge and higher consumption of protein foods than those from Piedras Negras, Coahuila. Thirty-five participants from both locations started and completed the DEI. After the intervention, there was an increase in participants’ scores in diabetes knowledge, positive attitudes towards the prevention of diabetes and self-efficacy for diabetes, and a decrease in their intake of grains and fats. Participants in Piedras Negras, Coahuila had greater improvements in positive attitudes towards the diabetes score than those in Lubbock, Texas. Conclusion: Findings from this study suggest that a DEI that integrates the use of the Nutrition Education DESIGN Procedure, Mexican cultural features and Spanish language is effective in improving diabetes-related factors and dietary intakes among Mexican-origin Hispanics in both the USA and Mexico.
Beyond formalized plans: User involvement in support in daily living – users’ and support workers’ experiences
Authors: Matscheck David , Ljungberg Amanda , Topor Alain 
Published: December 2019

Background: User involvement, based on respect and carried out through dialogue, has been shown to lead to increased self-respect, self-confidence and positive identity. In Sweden, the Social Service Act requires that interventions be designed and implemented together with the individual concerned. The basic criterion for social support is prolonged severe mental illness (usually at least 6 months), with no criteria for specific diagnosis or institutional history. The most common form of social support is ‘support in daily living’, a community care intervention for people aged 18 years or older who have their own homes and living arrangements. Aim: This article aims to deepen our understanding of user involvement at the individual level in the provision of an ongoing social work intervention. What elements of user involvement can be found in users’ and support workers’ descriptions of helpful support in daily living? Method: Qualitative interviews were conducted with 18 users, who had experienced support in daily living as helpful, and 16 interviews with the users’ support workers. Results: Three major, interconnected themes emerged: Constant dialogue; Framing the flexibility, in relation to formalized intervention plans and regulations; The importance of ‘small things’, decisions concerning daily life. Conclusion: Both users and support workers described user involvement at the individual, micro-level to be an integral part of helpful support in daily living. It was possible to create a space for dialogue and co-creation in which users were involved in formulating and deciding the contents of their support at an informal level, to influence their own everyday lives. While a formal framework of rules, restrictions and plans surrounds meetings between users and professionals, a facilitating factor may be the absence of too detailed plans and regulations, leaving trust to users and professionals and their capacity to manage most of the choices they have to make.
Performance and Priorities: A Cross-sectional Study of Local Health Department Approaches to Essential Public Health Services
Authors: Wallace Megan , Sharfstein Joshua , Lessler Justin 
Published: December 2019

Objectives: Despite a push for increased local public health capacity, no clear baseline for performance of local health departments (LHDs) exists. The objectives of this study were to quantify the self-reported performance of LHDs on the 10 Essential Public Health Services (EPHSs) and describe the relationships between performance and characteristics of LHDs. Methods: We used data on 2000 LHDs from the 2013 National Profile of Local Health Departments survey to develop principal components analysis–based scores to evaluate each LHD on the performance of EPHSs. Scores ranged from 0 to 100. LHDs that performed no activities within an EPHS had a score of 0, and LHDs that performed all activities within an EPHS had a score of 100. We explored the relationships between EPHS scores and LHD characteristics by using multivariate linear regression and cluster analysis. Results: Performance scores varied greatly by LHDs and EPHSs; however, LHDs typically scored <50, indicating that they performed fewer than half of the activities evaluated. LHDs that served larger populations (vs smaller populations) and LHDs that had higher per-capita funding (vs lower per-capita funding) had higher EPHS scores. We identified 6 EPHS performance score–based LHD clusters, which suggests similarities in which EPHSs LHDs focused on. Conclusions: Our results suggest weaknesses in many LHDs’ fulfillment of the EPHSs, particularly in low-population and low-funding settings. LHDs should be given the resources to increase capacity and ensure the EPHSs are met in communities.
Long-term antithrombotic therapy after venous stent placement
Authors: Lin Chenyu , Martin Karlyn A , Wang Mei , Stein Brady L , Desai Kush R 
Published: December 2019

Objectives To examine the prescribing patterns and outcomes of antithrombotic regimens after venous stent placement. Methods A total of 87 patients who received inferior vena cava or iliofemoral venous stents were included in the study. A retrospective review was performed to determine the antithrombotic regimens and the subsequent rates of in-stent restenosis, stent thrombosis, and bleeding. Results The prescribing patterns of specific antithrombotic regimens were highly variable. In-stent restenosis and stent thrombosis events were observed in 13 of 63 patients (21%) with available follow-up imaging, while major bleeding events were noted in 6 of 87 patients (7%). Triple therapy appeared to reduce the odds of in-stent restenosis/ stent thrombosis when compared to dual antiplatelet therapy (OR = 0.07, P = 0.01). Conclusions Substantial variability exists in antithrombotic therapy following venous stenting at our institution. This study demonstrated a reduction of in-stent restenosis/thrombosis events when utilizing triple therapy compared to antiplatelet-only regimens. However, larger prospective trials are needed to more accurately determine the relative risks and benefits of each antithrombotic regimen.
Inferior Vena Cava Volume Is an Independent Predictor of Massive Transfusion in Patients With Trauma
Authors: Chien Chih-Ying , Yan Jiun-Lin , Han Shih Tsung , Chen Jin-Tang , Huang Ting-Shuo , Chen Yu-Hsien , Wang Chih-Yuan , Lee Yueh-Lin , Chen Kuan-Fu 
Published: December 2019

Objectives: Early adequate resuscitation of patients with trauma is crucial in preventing shock and early mortality. Thus, we aimed to determine the performance of the inferior vena cava (IVC) volume and other risk factors and scores in predicting massive transfusion and mortality. Methods: We included all patients with trauma who underwent computed tomography (CT) scan of the torso, which included the abdominal area, in our emergency department (ED) from January 2014 to January 2017. We calculated the 3-dimensional IVC volume from the left renal vein to the IVC bifurcation. The primary outcome was the performance of IVC volume in predicting massive transfusion, and the secondary outcome was the performance of IVC volume in predicting 24-hour and 30-day in-hospital mortality. Results: Among the 236 patients with trauma, 7.6% received massive transfusions. The IVC volume and revised trauma score (RTS) were independent predictors of massive transfusion (adjusted odds ratio [OR]: 0.79 vs 1.86, 95% confidence interval [CI], 0.71-0.89 vs 1.4-2.47, respectively). Both parameters showed the good area under the curve (AUC) for the prediction of massive transfusion (adjusted AUC: 0.83 and 0.82, 95% CI, 0.74-0.92 vs 0.72-0.93, respectively). Patients with a large IVC volume (fourth quartile) were less likely to receive massive transfusion than those with a small IVC volume (first quartile, ≥28.29 mL: 0% vs <15.08 mL: 20.3%, OR: 0.13, 95% CI, 0.03-0.66). Conclusions: The volume of IVC measured on CT scan and RTS are independent predictors of massive transfusion in patients with trauma in the ED.
Identification of differential gene expression related to epirubicin-induced cardiomyopathy in breast cancer patients
Authors: Peng J , Wang Z , Li Y , Lv D , Zhao X , Gao J , Teng H 
Published: December 2019

Background: Epirubicin is a potent chemotherapeutic agent for the treatment of breast cancer. However, it may lead to cardiotoxicity and cardiomyopathy, and no reliable biomarker was available for the early prediction of epirubicin-induced cardiomyopathy. Methods: Global gene expression changes of peripheral blood cells were studied using high-throughput RNA sequencing in three pair-matched breast cancer patients (patients who developed symptomatic cardiomyopathy paired with patients who did not) before and after the full session of epirubicin-based chemotherapy. Functional analysis was conducted using gene ontology and pathway enrichment analysis. Results: We identified 13 significantly differentially expressed genes between patients who developed symptomatic epirubicin-induced cardiomyopathy and their paired control who did not. Among them, the upregulated Bcl-associated X protein was related to “apoptosis,” while the downregulated 5′-aminolevulinate synthase 2 (ALAS2) was related to both “glycine, serine, and threonine metabolism” and “porphyrin and chlorophyll metabolism” in pathway enrichment analysis. Conclusions: ALAS2 and the metabolic pathways which were involved may play an important role in the development of epirubicin-induced cardiomyopathy. ALAS2 may be useful as an early biomarker for epirubicin-induced cardiotoxicity detection.
Seasonal Variation of Chronic Villitis of Unknown Etiology
Authors: Freedman Alexa A , Goldstein Jeffery A , Miller Gregory E , Borders Ann , Keenan-Devlin Lauren , Ernst Linda M 
Published: December 2019

Introduction Chronic villitis of unknown etiology (VUE) is a chronic inflammatory lesion of the placenta. VUE is hypothesized to result from an alloimmune response or as response to an unidentified infection. Lack of a seasonal trend is thought to support VUE as an alloimmune response, though data on seasonal VUE trends are limited. Methods Data were obtained from a hospital in Chicago, Illinois, from 2011–2016. Placentas sent to pathology were reviewed using a standardized protocol, and VUE cases were identified based on an automated text search of pathology records. We used monthly VUE prevalence estimates to investigate the annual trend, and we used Poisson regression to evaluate seasonal variation in the number of VUE cases. Results There were 79 825 deliveries within the study period. Pathologists evaluated 12 074 placentas and identified 2873 cases of VUE. Regression results indicate that the risk of VUE is 16% to 17% higher in the fall and winter as compared to the summer (fall relative risk [RR]: 1.17, 95% confidence interval [CI]: 1.06–1.29; winter RR: 1.16, 95% CI: 1.05–1.29). Discussion Our results suggest that there may be seasonal variation in VUE prevalence, particularly for low-grade VUE. Future studies should evaluate seasonal variation in a representative sample rather than relying on pathology reports to estimate prevalence.