bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the Unified Motive Scales
Authors: Bettschart Martin , Herrmann Marcel , Wolf Benjamin M. , Brandstätter Veronika 
Published: March 2020

Abstract. Explicit motives are well-studied in the field of personality and motivation psychology. However, the statistical overlap of different explicit motive measures is only moderate. As a consequence, the Unified Motive Scales (UMS; Schönbrodt & Gerstenberg, 2012 ) were developed to improve the measurement of explicit motives. The present longitudinal field study examined the predictive validity of the UMS achievement motive subscale. Applicants of a police department ( n = 168, Mage = 25.11, 53 females and 115 males) completed the UMS and their performance in the selection process was assessed. As expected, UMS achievement predicted success in the selection process. The findings provide first evidence for the predictive validity of UMS achievement in an applied setting.
Sea Level Change Controlled the Sedimentary Processes at the Makran Continental Margin Over the Past 13,000 yr
Authors: He Wei , Liu Jianguo , Huang Yun , Cao Li 
Published: March 2020

AbstractClimate change, sea level fluctuations, and tectonic uplift play key roles in the evolution of sedimentary systems on continental margins. In the Arabian Sea, the Makran continental margin is suitable for studying these processes during the Holocene due to its high sedimentation rate and continuous sequence of Holocene sediments. Here, high‐resolution clay mineral and grain size analyses have been conducted to better understand the sedimentary process and controlling factors over the past 13,000 yr. The results show that the influence of Indus‐derived sediments on the Makran continent margin is negligible. Holocene relative sea level fluctuations can strongly control the shelf accommodation space due to the narrow shelf, which in turn affects the deposition process at the Makran continental margin. The sediment records at the central Makran continental margin are more suitable for studying ancient earthquakes or tsunamis.
Water Mass Characteristics and Distribution Adjacent to Larsen C Ice Shelf, Antarctica
Authors: Hutchinson Katherine , Deshayes Julie , Sallee Jean‐Baptiste , Dowdeswell Julian A. , de Lavergne Casimir , Ansorge Isabelle , Luyt Hermann , Henry Tahlia , Fawcett Sarah E. 
Published: March 2020

AbstractThe physical oceanographic environment, water mass characteristics, and distribution in the area adjacent to Larsen C Ice Shelf (LCIS) are investigated using hydrographic data collected during the 2019 Weddell Sea Expedition. The results shed light on the ocean conditions adjacent to a thinning LCIS, on a continental shelf that is a source region for Weddell Sea Deep Water (WSDW), a precursor of the globally important Antarctic Bottom Water. Modified Warm Deep Water (MWDW), a water mass of circumpolar origin, is identified on the continental shelf and is observed to mix with Ice Shelf Water (ISW) and High Salinity Shelf Water (HSSW), both source waters of WSDW. A source water type decomposition analysis reveals high levels of mixing in the area, with much spatial variability. Heat content anomalies indicate an introduction of heat, presumed to be associated with MWDW, into the area via Jason Trough. Furthermore, candidate parent sources for ISW are identified in the region, indicating the potential for a flow of continental shelf waters into the ice shelf cavity; however, the impact on LCIS cannot be surmised from the available observations. ISW and HSSW are observed to make dominant contributions to the densest layers within Jason Trough, where waters are likely en route to feed the deep layers of the Antarctic Slope Current. This cross‐shelf flux of water masses links the region of the Weddell Sea adjacent to northern LCIS to global ocean circulation and Bottom Water characteristics via its contribution to ISW and HSSW, and hence WSDW properties.
A Comparison of Factors Driving Flood Losses in Households Affected by Different Flood Types
Authors: Mohor G. S. , Hudson P. , Thieken A. H. 
Published: March 2020

AbstractFlood loss data collection and modeling are not standardized, and previous work has indicated that losses from different flood types (e.g., riverine and groundwater) may follow different driving forces. However, different flood types may occur within a single flood event, which is known as a compound flood event. Therefore, we aimed to identify statistical similarities between loss‐driving factors across flood types and test whether the corresponding losses should be modeled separately. In this study, we used empirical data from 4,418 respondents from four survey campaigns studying households in Germany that experienced flooding. These surveys sought to investigate several features of the impact process (hazard, socioeconomic, preparedness, and building characteristics, as well as flood type). While the level of most of these features differed across flood type subsamples (e.g., degree of preparedness), they did so in a nonregular pattern. A variable selection process indicates that besides hazard and building characteristics, information on property‐level preparedness was also selected as a relevant predictor of the loss ratio. These variables represent information, which is rarely adopted in loss modeling. Models shall be refined with further data collection and other statistical methods. To save costs, data collection efforts should be steered toward the most relevant predictors to enhance data availability and increase the statistical power of results. Understanding that losses from different flood types are driven by different factors is a crucial step toward targeted data collection and model development and will finally clarify conditions that allow us to transfer loss models in space and time.
Impact of maternal obesity on placental transcriptome and morphology associated with fetal growth restriction in mice
Authors: de Barros Mucci Daniela , Kusinski Laura C. , Wilsmore Phoebe , Loche Elena , Pantaleão Lucas C. , Ashmore Thomas J. , Blackmore Heather L. , Fernandez-Twinn Denise S. , Carmo Maria das Graças T. do , Ozanne Susan E. 
Published: March 2020

AbstractBackgroundIn utero exposure to obesity is consistently associated with increased risk of metabolic disease, obesity and cardiovascular dysfunction in later life despite the divergence of birth weight outcomes. The placenta plays a critical role in offspring development and long-term health, as it mediates the crosstalk between the maternal and fetal environments. However, its phenotypic and molecular modifications in the context of maternal obesity associated with fetal growth restriction (FGR) remain poorly understood.MethodsUsing a mouse model of maternal diet-induced obesity, we investigated changes in the placental transcriptome through RNA sequencing (RNA-seq) and Ingenuity Pathway Analysis (IPA) at embryonic day (E) 19. The most differentially expressed genes (FDR < 0.05) were validated by Quantitative real-time PCR (qPCR) in male and female placentae at E19. The expression of these targets and related genes was also determined by qPCR at E13 to examine whether the observed alterations had an earlier onset at mid-gestation. Structural analyses were performed using immunofluorescent staining against Ki67 and CD31 to investigate phenotypic outcomes at both timepoints.ResultsRNA-seq and IPA analyses revealed differential expression of transcripts and pathway interactions related to placental vascular development and tissue morphology in obese placentae at term, including downregulation ofMuc15,Cnn1, andActa2.Pdgfb, which is implicated in labyrinthine layer development, was downregulated in obese placentae at E13. This was consistent with the morphological evidence of reduced labyrinth zone (LZ) size, as well as lower fetal weight at both timepoints irrespective of offspring sex.ConclusionsMaternal obesity results in abnormal placental LZ development and impaired vascularization, which may mediate the observed FGR through reduced transfer of nutrients across the placenta.
Alzheimer-related genes show accelerated evolution
Authors: Nitsche Anne , Arnold Christian , Ueberham Uwe , Reiche Kristin , Fallmann Jörg , Hackermüller Jörg , Horn Friedemann , Stadler Peter F. , Arendt Thomas 
Published: March 2020

AbstractAlzheimerʼs disease (AD) is a neurodegenerative disorder of unknown cause with complex genetic and environmental traits. While AD is extremely prevalent in human elderly, it hardly occurs in non-primate mammals and even non-human-primates develop only an incomplete form of the disease. This specificity of AD to human clearly implies a phylogenetic aspect. Still, the evolutionary dimension of AD pathomechanism remains difficult to prove and has not been established so far. To analyze the evolutionary age and dynamics of AD-associated-genes, we established the AD-associated genome-wide RNA-profile comprising both protein-coding and non-protein-coding transcripts. We than applied a systematic analysis on the conservation of splice-sites as a measure of gene-structure based on multiple alignments across vertebrates of homologs of AD-associated-genes. Here, we show that nearly all AD-associated-genes are evolutionarily old and did not originate later in evolution than not-AD-associated-genes. However, the gene-structures of loci, that exhibit AD-associated changes in their expression, evolve faster than the genome at large. While protein-coding-loci exhibit an enhanced rate of small changes in gene structure, non-coding loci show even much larger changes. The accelerated evolution of AD-associated-genes indicates a more rapid functional adaptation of these genes. In particular AD-associated non-coding-genes play an important, as yet largely unexplored, role in AD. This phylogenetic trait indicates that recent adaptive evolution of human brain is causally involved in basic principles of neurodegeneration. It highlights the necessity for a paradigmatic change of our disease-concepts and to reconsider the appropriateness of current animal-models to develop disease-modifying strategies that can be translated to human.
The long non-coding RNA PIK3CD-AS2 promotes lung adenocarcinoma progression via YBX1-mediated suppression of p53 pathway
Authors: Zheng Xiufen , Zhang Junying , Fang Tian , Wang Xiaoxiao , Wang Siwei , Ma Zhifei , Xu Youtao , Han Chencheng , Sun Mengting , Xu Lin , Wang Jie , Yin Rong 
Published: March 2020

AbstractThe underlying mechanisms of long non-coding RNAs (lncRNA) participating in the progression of lung cancers are largely unknown. We found a novel lncRNA, PIK3CD antisense RNA 2 (PIK3CD-AS2), that contributes to lung adenocarcinoma (LUAD) progression. The expression characteristics of PIK3CD-AS2 in LUAD were analyzed using microarray expression profile, The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets, and validated in 92 paired LUAD tissues by chromogenic in situ hybridization. Our data confirmed that PIK3CD-AS2 expression is a crucial regulator of LUAD progression and associated with shorter patient survival. In vitro studies showed that PIK3CD-AS2 increased cell growth and slowed apoptosis in p53wt cells but not in p53null cells. Mechanically, it is demonstrated that PIK3CD-AS2 bound to and maintained the stability of Y-box binding protein 1 (YBX1), a potent destabilizer of p53, by impeding its ubiquitination and degradation. Downexpression of YBX1 reversed PIK3CD-AS2-mediated inhibition of p53 signaling. Additionally, the therapeutic effect evaluation of a locked nuclear acid (LNA) specifically targeting PIK3CD-AS2 showed an anti-tumor activity in mice with A549 cells xenograft and p53 wild-type LUAD patient-derived tumor xenograft (PDTX) model. Clinically, the high expression of PIK3CD-AS2 showed a poor disease-free survival in p53 wild-type patients in TCGA database. Our findings suggest that PIK3CD-AS2 regulates LUAD progression and elucidate a new PIK3CD-AS2/YBX1/p53 signaling axis, providing a potential lncRNA-directed therapeutic strategy especially in p53 wild-type LUAD patients.
A liquid biopsy to detect multidrug resistance and disease burden in multiple myeloma
Authors: Rajeev Krishnan Sabna , De Rubis Gabriele , Suen Hayley , Joshua Douglas , Lam Kwan Yiu , Bebawy Mary 
Published: March 2020

AbstractMultiple myeloma is an incurable cancer of bone marrow plasma cells, with a 5-year survival rate of 43%. Its incidence has increased by 126% since 1990. Treatment typically involves high-dose combination chemotherapy, but therapeutic response and patient survival are unpredictable and highly variable—attributed largely to the development of multidrug resistance (MDR). MDR is the simultaneous cross-resistance to a range of unrelated chemotherapeutic agents and is associated with poor prognosis and survival. Currently, no clinical procedures allow for a direct, continuous monitoring of MDR. We identified circulating large extracellular vesicles (specifically microparticles (MPs)) that can be used to monitor disease burden, disease progression and development of MDR in myeloma. These MPs differ phenotypically in the expression of four protein biomarkers: a plasma-cell marker (CD138), the MDR protein, P-glycoprotein (P-gp), the stem-cell marker (CD34); and phosphatidylserine (PS), an MP marker and mediator of cancer spread. Elevated levels of P-gp+and PS+MPs correlate with disease progression and treatment unresponsiveness. Furthermore, P-gp, PS and CD34 are predominantly expressed in CD138−MPs in advanced disease. In particular, a dual-positive (CD138−P-gp+CD34+) population is elevated in aggressive/unresponsive disease. Our test provides a personalised liquid biopsy with potential to address the unmet clinical need of monitoring MDR and treatment failure in myeloma.
Root transcriptome reveals efficient cell signaling and energy conservation key to aluminum toxicity tolerance in acidic soil adapted rice genotype
Authors: Tyagi Wricha , Yumnam Julia S. , Sen Devyani , Rai Mayank 
Published: March 2020

AbstractAluminium (Al) toxicity is the single most important contributing factor constraining crop productivity in acidic soils. Hydroponics based screening of three rice genotypes, a tolerant (ARR09, AR), a susceptible (IR 1552, IR) and an acid soil adapted landrace (Theruvii, TH) revealed that AR accumulates less Al and shows minimum decrease in shoot and root biomass under Al toxicity conditions when compared with IR. Transcriptome data generated on roots (grown in presence or absence of Al) led to identification of ~1500 transcripts per genotype with percentage annotation ranging from 21.94% (AR) to 29.94% (TH). A total of 511, 804 and 912 DEGs were identified in genotypes AR, IR and TH, respectively. IR showed upregulation of transcripts involved in exergonic processes. AR appears to conserve energy by downregulating key genes of glycolysis pathway and maintaining transcript levels of key exergonic step enzymes under Al stress. The tolerance in AR appears to be as a result of novel mechanism as none of the reported Al toxicity genes or QTLs overlap with significant DEGs. Components of signal transduction and regulatory machinery like transcripts encoding zinc finger protein, calcieurin binding protein and cell wall associated transcripts are among the highly upregulated DEGs in AR, suggesting increased and better signal transduction in response to Al stress in tolerant rice. Sequencing ofNRAT1 and glycine-rich protein A3 revealed distinct haplotype forindicatype AR. The newly identified components of Al tolerance will help in designing molecular breeding tools to enhance rice productivity in acidic soils.
Study of Heat and Mass Transfer in MHD Flow of Micropolar Fluid over a Curved Stretching Sheet
Authors: Yasmin Asia , Ali Kashif , Ashraf Muhammad 
Published: March 2020

AbstractA comprehensive investigation of mass and heat transfer in magnetohydrodynamics (MHD) flow of an electrically conducting non-Newtonian micropolar fluid because of curved stretching sheet is presented. Flow is originated by stretching of curved sheet by means of linear velocity. Concentration and energy equations are incorporated to study repercussion of mass and heat transfer. To define basic equations of the model, curvilinear coordinates are used. The transformed BL (boundary layer) equations for the momentum, concentration, angular momentum and temperature with appropriate boundary conditions are numerically solved by SOR (successive over relaxation) algorithms combined with the quasi-linearization technique. Flow features such as temperature fields, micro rotation, velocity and concentration are appraised for manipulation of pertinent parameters. The radius of curvature enhances the temperature and concentration whereas it declines micro-rotation as well as velocities of the fluid. It is significant to notice that magnetic field interaction is caused counterproductive in increasing concentration distribution and fluid temperature while diminishing micro-rotation and velocities at all domain flow points. As schmidt number increases concentration of fluid reduces.
Radiocarbon chronology and environmental context of Last Glacial Maximum human occupation in Switzerland
Authors: Reade Hazel , Tripp Jennifer A. , Charlton Sophy , Grimm Sonja , Sayle Kerry L. , Fensome Alex , Higham Thomas F. G. , Barnes Ian , Stevens Rhiannon E. 
Published: March 2020

AbstractCentral Europe during the Last Glacial Maximum (LGM) was dominated by polar desert and steppe-tundra biomes. Despite this, a human presence during this time period is evident at several locations across the region, including in Switzerland, less than 50 km from the Alpine ice sheet margin. It has been hypothesised that such human activity may have been restricted to brief periods of climatic warming within the LGM, but chronological information from many of these sites are currently too poorly resolved to corroborate this. Here we present a revised chronology of LGM human occupation in Switzerland. AMS radiocarbon dating of cut-marked reindeer (Rangifer tarandus) bones from the sites of Kastelhöhle-Nord and Y-Höhle indicates human occupation of Switzerland was most likely restricted to between 23,400 and 22,800 cal. BP. This timeframe corresponds to Greenland Interstadial 2, a brief warming phase, supporting the hypothesis that human presence was facilitated by favourable climatic episodes. Carbon, nitrogen and sulphur stable isotope analysis of the fauna provides palaeoenvironmental information for this time period. These findings contribute to our understanding of human activity in ice-marginal environments and have implications for understanding cultural connections across central Europe during the LGM.
Application of Continuous Intraoperative Neuromonitoring During VATS Lobectomy for Left Lung Cancer to Prevent Recurrent Laryngeal Nerve Injury
Authors: Chai Young Jun , Lee Jung-Man , Seong Yong Won , Moon Hyeon Jong 
Published: March 2020

AbstractWe applied continuous intraoperative neuromonitoring (CIONM) during video-assisted thoracoscopic surgery (VATS) lobectomy for left lung cancer and evaluated its safety and usefulness. An electrode was attached to a double-lumen tube, and placed at vocal cord level to detect the EMG signal evoked by vocal cord movement. Before 4 L lymph node dissection, an automatic periodic stimulation device was applied to the vagus nerve to stimulate vagus nerve continuously. Surgery was suspended if the amplitude decreased lower than the threshold and was resumed when the amplitude recovered. Ten patients (6 male, 4 female) were enrolled. CIONM was successfully performed in all patients without technical failure, and there was no hemodynamic instability. Amplitude decreased below the threshold in four patients. One patient did not recover amplitude and experienced transient vocal cord palsy. In the three other patients, the amplitude recovered above the threshold and no vocal cord palsy occurred. The six patients who did not exhibit amplitude decrease experienced no vocal cord palsy. Our results suggest that CIONM may be applied safely for VATS left lobectomy and may be used to predict postoperative vocal cord function. This approach may be helpful to prevent RLN injury during VATS left lobectomy.
Strain relaxation in InAs heteroepitaxy on lattice-mismatched substrates
Authors: Ohtake Akihiro , Mano Takaaki , Sakuma Yoshiki 
Published: March 2020

AbstractStrain relaxation processes in InAs heteroepitaxy have been studied. While InAs grows in a layer-by-layer mode on lattice-mismatched substrates of GaAs(111)A, Si(111), and GaSb(111)A, the strain relaxation process strongly depends on the lattice mismatch. The density of threading defects in the InAs film increases with lattice mismatch. We found that the peak width in x-ray diffraction is insensitive to the defect density, but critically depends on the residual lattice strain in InAs films.
Perception of Discrete Emotions in Others: Evidence for Distinct Facial Mimicry Patterns
Authors: Wingenbach Tanja S. H. , Brosnan Mark , Pfaltz Monique C. , Peyk Peter , Ashwin Chris 
Published: March 2020

AbstractCovert facial mimicry involves subtle facial muscle activation in observers when they perceive the facial emotional expressions of others. It remains uncertain whether prototypical facial features in emotional expressions are being covertly mimicked and also whether covert facial mimicry involves distinct facial muscle activation patterns across muscles per emotion category, or simply distinguishes positive versus negative valence in observed facial emotions. To test whether covert facial mimicry is emotion-specific, we measured facial electromyography (EMG) from five muscle sites (corrugator supercilii, levator labii, frontalis lateralis, depressor anguli oris, zygomaticus major) whilst participants watched videos of people expressing 9 different basic and complex emotions and a neutral expression. This study builds upon previous research by including a greater number of facial muscle measures and emotional expressions. It is the first study to investigate activation patterns across muscles during facial mimicry and to provide evidence for distinct patterns of facial muscle activation when viewing individual emotion categories, suggesting that facial mimicry is emotion-specific, rather than just valence-based.
Study on the Change of Dielectric Properties and Chemical-Mechanism during Coal Low-Temperature Oxidation
Authors: Zhu Hongqing , Wang Haoran , Wang Wei , Liu Jiuli 
Published: March 2020

AbstractThe study aims to investigate the variation of the coal dielectric properties during coal low-temperature oxidation and the effect of oxidation product on the coal dielectric properties. Four different types of coal were prepared under low-temperature oxidation condition, and the coal dielectric properties were measured with an impedance analyzer at frequencies ranging between 20 Hz and 30 MHz. The oxygen-containing functional groups in oxidized coal samples were semi-quantitatively evaluated using Fourier transform infrared spectroscopy. Low-temperature oxidation stage of coal spontaneous combustion could be predicted according to the change of coal dielectric properties in the process of temperature rise. It was found that the dielectric constant of coal with high water content decreased exponentially with temperature. For coal sample with low water content, the dielectric properties changed piecewise linearly with temperature. Coal dehydration was considered to be the reason for the decrease of the dielectric constant from 30 °C to 120 °C. The increase of the relative content of oxygen-containing functional groups, especially carbonyl compounds, could be the reason for the rise of the coal dielectric constant from T2 to T3.