bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peritumoral ductular reaction can be a prognostic factor for intrahepatic cholangiocellular carcinoma
Authors: Shen Zhenyang , Xiao Jingbo , Wang Junjun , Lu Lungen , Wan Xinjian , Cai Xiaobo 
Published: March 2020

Abstract
Background: Peritumoral ductular reaction (DR) was reported to be related to the prognosis of combined hepatocellular-cholangiocarcinoma and hepatocellular carcinoma. Non-mucin-producing intrahepatic cholangiocellular carcinoma (ICC), may be derived from small bile duct cells or liver progenitor cells (LPCs). However, whether peritumoral DR is also related to non-mucin-producing ICCs needs to be investigated. Methods: Forty-seven patients with non-mucin-producing ICC were eventually included in the study. Clinicopathological variables were collected. Immunohistochemical analysis and immunofluorescence staining for cytokeratin 19, proliferating cell nuclear antigen, and α-smooth muscle actin were performed in tumor and peritumor liver tissues.Results: Peritumoral DR is significantly correlated with local inflammation and fibrosis. Patients with significant peritumoral DR had high recurrence rate(81.8% vs 56.0%, P = 0.058) and poor overall and disease-free survival time ( P = 0.01 and P = 0.03, respectively). Significant peritumoral DR showed high proliferation activity of LPC/cholangiocytes and abundant background extracellular matrix. Conclusions: Patients with non-mucin-producing ICC having significant peritumoral DR had a poor prognosis. Peritumoral DR could be a prognostic factor for ICC; however, the mechanism should be further investigated. Keywords: Intrahepatic cholangiocellular carcinoma, non-mucin producing, ductular reaction, prognostic factor
Association between Cough Severity and Quality of Life Depends on Sex among Patients with Postinfectious Cough
Authors: Wei Liu , Qinqin Wu , Bing Mao , Jiang Hongli 
Published: March 2020

Abstract
Background: Sex difference in quality of life (QoL) and association between cough severity and QoL for subacute cough remains unknown. This study aimed to investigate whether there was sex difference in quality of life, and whether association between cough severity and QoL was modified by sex. Methods: Secondary analyses were performed in 180 participants with postinfectious cough in a multisite randomized controlled trial. Baseline demographics, clinical characteristics and cough specific quality of life questionnaire (CQLQ) were collected. Linear regression analyses were conducted to examine sex difference in CQLQ. Associations between cough severity, cough treatment and CQLQ in different sex were also analyzed. Results: The differences between women and men were not significant in the total CQLQ in the unadjusted analysis (P = 0.077). Women had 2.20-point higher total CQLQ score than men (0.11 to 4.30, P = 0.039), after adjusting for age, cough duration, cough severity, and clinical center. An increase of 1-point in cough severity was associated with a 2.55-point (1.16 to 3.95) increase in total CQLQ in women versus a 1.26-point (0.20 to 2.31) increase in men (P = 0.020). Sex did not modify treatment benefit in total CQLQ in both unadjusted and adjusted analyses (P = 0.287 and P = 0.819, respectively). Conclusions: Women may be associated with worse quality of life than men, and women’s quality of life is more significantly impaired as cough severity increases. However, they may have similar treatment response in QoL improvement.Trial registration: Chinese Clinical Trial Registry, ChiCTRTRC12002297. Registered 19 June 2012, http://www.chictr.org.cn/abouten.aspx
Systematic review of the tools of oral and dental health literacy: Assessment of conceptual dimensions and psychometric properties
Authors: Ghaffari Mohtasham , Rakhshanderou Sakineh , Ramezankhani Ali , Mehrabi Yadollah , Safari-Moradabadi Ali 
Published: March 2020

Abstract
Background This article aims to provide a description of conceptual dimensions and psychometric properties of the tools of oral and dental health literacy. Methods Two authors in this study conducted electronic searches in the Medline (via PubMed), and Embase databases to find relevant articles from 1990 to present day. Evaluation of the tools was carried out in two parts; general evaluation of the tools using skills introduced by Sørensen et al., and qualitative assessment of psychometric properties using COSMIN checklist. Results After reviewing 1839 articles on oral and dental health literacy and evaluating 33 full text articles for eligibility, 21 articles entered the study. The sample size varied from 20 to 1405 subjects and the items of each tool ranged from 11 to 99 items. Of the 21 tools examined, 16 tools were evaluated for word recognition. For the studies examined, the evaluation of COSMIN scores was often fair or good. Of the 21 tools examined, 9 tools at least in one dimension were in the category of "poor", 19 tools were in the category of "fair", 20 tools were in the category of "good", and 4 tools were in the category of "excellent" in at least one dimension. Conclusion The findings of this study showed that some aspects of oral and dental health literacy are being ignored in the existing tools. Therefore, the authors of present study emphasize on the necessity to design and develop a comprehensive tool and take into account two characteristics of simplicity and briefness for international use.
Biodegradation of polycyclic aromatic hydrocarbons, phenol and sodium sulfate by Nocardia species Isolated and characterized from Iranian ecosystem.
Authors: Azadi Davood , Shojaei Hasan 
Published: March 2020

Abstract
Background Industrial products are persistently hazardous pollutants to the environment and are of current concern to human health. Bioremediation, a process used to treat contaminated environment is an option that enhances the efficacy of the natural biodegradation process and degrade the target pollutants. Different species of bacteria have been reported for their ability to degrade pollutants to the environment. Nocardia live in diverse unfavorable environmental conditions and have a high catabolic capacity. This study aimed to screen and characterize Nocardia with bioremediation capability from Iranian diverse ecosystems. Result A total of 90 collected environmental samples were screened for Nocardia spp. The isolates were characterized based on conventional and molecular methods including sequence analysis of 16S rRNA. Growth rate in presence of pollutants, chromatography, Gibbs and turbidometric methods were used to determine bioremediation ability. The Nocardia isolates included 19 strains that belonged to 10 various species. The most prevalent Nocardia species were N. farcinica, 4 isolates (21%), followed by N. cyriacigeorgica and N. cashijiensis like, 3 isolates each (15.7%), and N. asteroids and N. kroppenstedtii 2 isolates each (10.5%). The isolates were classified in two categories based on their bioremediation ability: isolates with previously reported that have a bioremediation ability, and the isolates that showed bioremediation ability that first reported in the current study. Conclusions Our study showed that Nocardia spp. demonstrate high ability to degrade environmental chemical pollutants placing this bacteria among the best candidates for the detoxification of habitats contaminated with this chemical compounds.
Allowing more time to ILCOR Step A of neonatal resuscitation leads to better residents’ task completion in simulated scenarios. A problem of time pressure?
Authors: Boithias Claire , Jule Laure , Foulgoc Stephanie Le , Jourdain Gilles , Benhamou Dan 
Published: March 2020

Abstract
Background: Roughly 10% of newborns need help to complete the transition of birth. For these infants, international guidelines recommend supporting them using a 4-step procedure (A to D). Step A is an assessment time, which includes eight tasks and finishes by starting the positive pressure ventilation (PPV), if necessary (step B). The guidelines changed in 2015 and the allotted time was raised from 30 to 60 seconds for step A completion. This study aimed to assess if the reduced time constraint in step A could have an impact on 1st-year pediatric residents' performance to complete step A and if could lead to later initiation of step A. Methods: Using video recordings of standardized neonatal scenarios over 6 years (3 before the change and 3 after), we assessed the ability of 1st-year pediatric residents of the Paris region to complete step A and initiate PPV in the allotted time in each period. Results: Among 52 sessions including at least 5 scenarios, we included all the second and fourth scenarios executed for the first time by a couple of 1st-year pediatric residents (25 sessions and 50 scenarios before the change, and 27 sessions and 54 scenarios after). PPV started roughly at 1-minute resuscitation in both periods, but completion of the tasks before PPV-start was significantly better in the second period. The improvement remained significant whatever the role played by residents during resuscitation.Conclusions:These results could suggest that a reduced time constraint for step A imposed by the new Guidelines was associated with better performance.
Simultaneous Integrated Boost of intensity modulated radiation therapy to Stage II-III Non-Small Cell Lung Cancer with metastatic lymph nodes
Authors: li qingsong , Liang Na , Ouyang Wei-Wei , Su Sheng-Fa , Ma Zhu , Geng Yi-Chao , Yang Wen-Gang , Hu Yin-Xiang , Li Hui-Qin , Lu Bing 
Published: March 2020

Abstract
Background: Local tumor failure remains a major problem after radiation-based nonsurgical treatment for unresectable locally advanced Non-Small Cell Lung Cancer （NSCLC）and inoperable stage II NSCLC .The aim of this study was to evaluate the feasibility of Simultaneous Integrated Boos of intensity modulated radiation therapy (SIB-IMRT) to Stage II-III NSCLC with metastatic lymph nodes. Methods: Patients were diagnosed by pathology or PET-CT. PTV was divide into two parts as follow, the PTV of primary tumor (PTVp) and the PTV of metastatic lymph nodes (PTVn) .The radiation doses were simultaneously prescripted 78Gy (BED = 101.48Gy) for PTVp and 60-65Gy (BED = 73.6-81.25Gy) for PTVn, 26f/ 5.2 weeks .Response was scored according to WHO criteria. Radiotherapy toxicity was scored according to RTOG criteria .Hematology and gastrointestinal toxicity were scored according to CTCAE1.0 criteria. Results: A total of 20 patients were enrolled. 17 patients were diagnosed by pathology and 3 patients were diagnosed by PET-CT . All patients were treated with SIB-IMRT. The objective response rate (ORR) was 90%, with CR 25%, PR 65%, NC 10% and PD 0%. Although Radiation toxicitiy was common, there were no grade≥3，with Radiation pneumonitis (10 cases), esophagitis (17 cases) and dermatitis (12 cases). The local control rates at 1, 3 and 5 years were 85%, 75% and 70%, respectively. The overall survival（OS）and local progression-free survival(LPFS) rates at 1, 3 and 5 years were 90%, 42.6%, 35.5% and 84.4%, 35.5% , 28.4%, respectively. The MST was 24 months. Conclusions: SIB-IMRT can significantly improve ORR and suivival for stage II-III NSCLC with metastatic lymph nodes , with high safety and satisfactory efficacy . Keywords: cancer/non-small-cell lung cancer; radiation therapy /SIB-IMRT; efficacy; safety Retrospective Trial Registration： (ChiCTR 2000029304)
Breast cancer survival in rural sub-Saharan Africa
Authors: Ssentongo Paddy , Oh John , Amponsah Forster , Wong William , Candela Xavier , Acharya Yubraj , Ssentongo Anna , Sani Abdul Basiti , Dodge Daleela 
Published: March 2020

Abstract
INTRODUCTION: Five-year overall survival rate of breast cancer in low-income countries (LICs) is significantly lower than in high-resource countries. In this study, we explored clinical and pathological factors influencing mortality in a rural community setting in sub-Saharan Africa. METHODS: We performed a retrospective medical review of patients undergoing surgery and chemotherapy for breast cancer at a regional hospital in Ghana from January 2014 through January 2017. Descriptive and survival analysis was done. RESULTS: One hundred and twenty-nine patients were included in the study. The median age at presentation was 51 years. 60.0% of patients presented with poorly differential histological grade III. The most common histological type was invasive ductal carcinoma (83%). Based on assessment of stage using only tumor size and lymph node status, 60% presented at stage 3. Only 25% were tested for hormone receptor proteins and HER2 status. Of these, 57% had triple-negative breast cancer (TNBC). The 3-year overall survival rate was only 52%. A significant proportion of the patients (46%) were lost to follow-up. CONCLUSIONS: The cumulative 3-year survival was 52 %. Despite success in the reduction of cancer mortality in southern and northern Africa, survival in the rural communities of sub-Saharan Africa remains poor. A significantly higher percentage of GIII and TNBC is found in breast cancers seen in Ghana. Late-stage presentation, when combined with limited capacity for accurate diagnosis, cancer subtype analysis, adequate therapy and follow-up, leads to poor outcomes. Future studies should emphasize identification of barriers to care and opportunities for cost-effective and sustainable improvements in the diagnosis and treatment of breast cancer in LICs.
PLEK2 and SCN7A: novel biomarkers of non-small cell lung cancer
Authors: Liu Yongchang , Li Xi , Chang Ruimin , Chen Yufan , Gao Yang 
Published: March 2020

Abstract
Objective Lung cancer is the leading cause of cancer-related death globally, and non-small cell lung cancer (NSCLC) is the most common type of lung cancer. However, the diagnosis and prognosis of NSCLC remain dim. Our team has focused on identifying differentially expressed genes (DEGs) between NSCLC tissues and adjacent tissues, which may be useful as effective diagnostic markers that can better explain the progression of NSCLC. Methods The Gene Expression Omnibus (GEO) database was used to screen the Gene Expression Omnibus series, which records the information of a large number of patients with primary NSCLC (n > 50). Then, the DEGs were validated using Student’s t -test. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using DAVID. The prognosis information was analyzed separately using data obtained from three databases, Human Protein Atlas, Kaplan–Meier Plotter, and SurvExpress. Results A series of 180 DEGs (33 upregulated and 147 downregulated genes), mainly involving genes associated with extracellular exosomes, focal adhesion, and cell adhesion, were identified via GO analysis. Subsequently, KEGG analysis demonstrated that focal adhesion, cell adhesion molecules, and PPAR signaling pathway were the most enriched pathways. Then, we paid particular attention to pleckstrin 2 (PLEK2) and sodium voltage-gated channel alpha subunit 7 (SCN7A), as they have not been investigated as cancer-related genes previously. Kaplan–Meier survival analysis illustrated that PLEK2 and SCN7A levels were significantly correlated with the prognosis of NSCLC. Conclusions Our research found that, as potential biomarkers, both PLEK2 and SCN7A are related to the development and prognosis of NSCLC. They may be used in disease screening and prognosis. The clinical significance of these two genes deserves further investigation.
HIV/AIDS Policy-Making in Iran: A Stakeholder Analysis
Authors: Khodayari-Zarnaq Rahim , Mosadeghrad Ali Mohammad , Jalilian Habib , bazyar mohammad , Ravaghi Hamid 
Published: March 2020

Abstract
Introduction: HIV/AIDS phenomenon is one of the most serious public health challenges which includes wide range of epidemiological, social, economic and political dimensions. Therefore, its effective control requires involvement of different stakeholders. The present study aims to identify and analyze HIV/AIDS stakeholders in Iran.Methods: This qualitative stakeholder analysis was conducted in 2018 nationwide both retrospectively and prospectively. Identification and analysis of stakeholders was carried out by the review of related literature and policy documents and official websites, as well as holding semi-structured interviews with policy makers and other key informants. Purposive sampling was utilized and followed by snowball sampling until data saturation. Data were analyzed using framework analysis. Also, qualitative data analysis software MAXQDA (Version 11) and Policy Maker software (version 4) were applied.Findings: A total of 44 stakeholders were identified and categorized into 23 active and 21 inactive stakeholders. Despite the great importance of educating and informing pubic about HIV/AIDS, the Ministry of Education and Islamic Republic of Iran Broadcasting organization (IRIB), have moderate participation in this regard. Supreme Council of Health and Non-governmental organizations (NGOs) have low participation. The Ministry of Health and Medical Education (MoHME), State Welfare Organization of Iran, Iranian Blood Transfusion Organization, the State Prisons and Security and Corrective Measures Organization are interested in HIV/AIDS policymaking. The MoHME, as main body responsible for stewardship of the HIV/AIDS in Iran, does not have enough authority in handling the issue due to the low funding, institutional and structural deficits and insufficient human resources.Conclusion: The process of HIV/AIDS policy making is fragmented in Iran and despite multiple active and passive stakeholders in this field, there is no integrated system to involve all stakeholders in the process of AIDS policy-making. Therefore, given the importance of the issue, an upstream entity is needed in order to coordinate and mobilize all stakeholders associated with managing and controlling HIV/AIDS.
Dezocine inhibits cell proliferation, migration and invasion by targeting CRABP2 in ovarian cancer
Authors: Zhang Chuanfeng , Pan Ruirui , Ma Shuangshuang , Xu Shoucai , Wang Baosheng 
Published: March 2020

Abstract
Background Previous studies have shown that some anesthesia drugs can inhibit tumor growth and metastasis. As a clinical anesthetic drug, dezocine has been reported to play an important role in immune function. However, the effects of dezocine on ovarian cancer cell growth and metastasis are not fully understood. Results In this study, we found that dezocine dose-dependently inhibited the viability of ES-2 and SKOV3 cells. Dezocine suppressed the migration and invasion abilities of ovarian cancer cells, and promoted apoptosis. Moreover, the Akt/mTOR signaling pathway was also inhibited by dezocine. Furthermore, mechanism study showed that dezocine could significantly inhibited the expression of CRABP2, and CRABP2 overexpression reversed the inhibitory effects of dezocine on ovarian cancer cell proliferation and migration. Conclusion In conclusion, dezocine has significant anti-tumor effects on the growth and metastatic potential of ovarian cancer cells, and CRABP2 functions as a downstream effector of dezocine.
Slanted bilateral lateral rectus recession for convergence insufficiency-type intermittent exotropia: a retrospective study
Authors: Ren Meiyu , Wang Qi , Wang Lihua 
Published: March 2020

Abstract
Background The present study sought to investigate the efficiency and safety of SBLR-rec for the treatment of CI-IXT.Methods This retrospective case series study included 34 patients who underwent SBLR-rec for CI-IXT in Shandong Provincial Hospital affiliated to Shandong University between September 2013 and October 2015 with a minimum follow-up of 6 months. A successful surgical alignment was defined as +5 to -10 prism diopters (PD) of orthophoria in the primary position while viewing distant or near targets and a difference between the distance and near deviation angles of ≤8PD.Results The mean age of the patients at surgery was 7.09±3.80 years (range, 3 to 18 years). The mean distance deviations were -26.09±6.5 PD (range, -15 to -35 PD) and the mean near deviations, -37.21±6.3 PD (range, -25 to -45 PD) preoperatively. The mean recession amount of upper pole of the lateral rectus was 5.97 mm (range, 4.0 to 7.5mm) and that of lower pole of the lateral rectus, 7.49 mm (range, 6.0 to 8.5mm). At a mean follow-up of 15.0 months (range, 6 to 37 months), the surgical success rate was 70.6% (24/34), the under-correction rate was 17.6% (6/34), and the overcorrection rate was 11.8% (4/34). The mean difference between the distance and near deviation angles was significantly reduced from 11.12±2.06 PD (range, 10 to 15 PD) preoperatively to 2.47±3.04 PD (range, 0 to 10 PD) postoperatively (P<0.001). Each millimeter of difference between the upper and lower poles of the lateral rectus recession was associated with an improvement of 5.65 PD in the near-distance difference of deviation. At the final follow up, a distance-near difference of deviation of ≤8PD was found in 32 (94.1%) patients. none of the patients developed A-V pattern, torsional diplopia, or restricted abduction of the eyes.Conclusions SBLR-rec for CI-IXT may successfully reduce the distance and near exodeviations and the distance-near deviation difference, thus was proved to be an effective and safe procedure for the treatment of CI-IXT.
The Diagnostic Value of the Short Physical Performance Battery for Sarcopenia
Authors: Phu Steven , Kirk Ben , Hassan Ebrahim Bani , Vogrin Sara , Zanker Jesse , Bernardo Solange , Duque Gustavo 
Published: March 2020

Abstract
BACKGROUND: Sarcopenia is defined as the age-related loss of muscle mass, strength and physical performance. The original European Working Group on Sarcopenia in Older Persons (EWGSOP1) definition, and its revision (EWGSOP2), provide new cut-points and alternate measures for sarcopenia diagnosis. However, sarcopenia is rarely diagnosed in clinical settings owing to its labour-intensive screening process. Given the Short Physical Performance Battery (SPPB) is a quick, easily administrable and objective measure of muscle strength and physical performance, both of which are key components of sarcopenia, this study examined the diagnostic value of the SPPB for this muscle disease.METHODS: A cross-sectional analysis of 294 community-dwelling older persons (≥65 years) was conducted. Appendicular lean body mass [(ALM) divided by height squared (ALM/h 2 )], muscle strength (handgrip/sit to stand), and physical performance [gait speed, timed up and go (TUG) and SPPB] were assessed using validated procedures, while participants were diagnosed with sarcopenia following the EWGSOP1 and EWGSOP2 criteria. Diagnostic ability of the SPPB independently and combined with ALM/h 2 for sarcopenia was determined using area under the curve (AUC). Potential cut-points were identified, and sensitivity and specificity calculated.RESULTS: Prevalence of sarcopenia ranged from 4 to 16% depending on the definition. The SPPB demonstrated moderate (AUC = 0.644-0.770) value in diagnosing sarcopenia, and a cut-point of ≤8points in SPPB performance resulted in high sensitivity (82-100%) but low specificity (36-41%) for diagnosing those with severe sarcopenia.CONCLUSIONS: The SPPB displayed acceptable value in diagnosing older adults with severe sarcopenia. Moreover, the high sensitivity of the SPPB when using the cut-point of ≤8 suggests it may be a favourable screening tool for sarcopenia in clinical settings where ALM measurements are not available.