bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of potential groundwater locations using geophysical data and fuzzy gamma operator model in Imo, Southeastern Nigeria
Authors: Abdulrazzaq Zaidoon T. , Agbasi Okechukwu E. , Aziz Nadia A. , Etuk Sunday E. 
Published: July 2020

AbstractGroundwater is among the most important resources of water supply of the worldwide population. The objective of this research is to select the most suitable drilling location of new groundwater wells, with a decision-making tool using geographic information system (GIS). The optimum location was evaluated based on the hydro-geoelectrical parameter derived from vertical electrical sounding (VES) including longitudinal conductance, aquifer thickness, aquifer resistivity, transmissivity, formation factor, and porosity. The analysis of the VES data revealed that the porosity values range from 1.8 to 21%, the formation factor values vary between 0.0355 and 0.14, the transmissivity values range from 3.4 to 6 m2/day, the longitudinal conductance values vary from 3 to 4.6 Ω−1, the aquifer thickness values range from 4.1 to 8.5 m, the aquifer resistivity varies between 0.7 and 40 Ω m. Hydro-geoelectrical data were integrated into GIS to precisely determine the best location for groundwater wells. Fuzzy liner membership was used to standardize the criteria layers; then, these layers were combined using fuzzy gamma overlay to produce the suitability map. The study area was classified into four classes: excluded, low suitability, moderate suitability, and high suitability. It is recommended that this method should be adopted by different governmental agencies involved in water resources management in Nigeria.
THE ABRI CASSEROLE (DORDOGNE, FRANCE): REASSESSING THE14C CHRONOLOGY OF A KEY UPPER PALEOLITHIC SEQUENCE IN SOUTHWESTERN FRANCE
Authors: Ducasse Sylvain , Pétillon Jean-Marc , Aubry Thierry , Chauvière François-Xavier , Castel Jean-Christophe , Detrain Luc , Langlais Mathieu , Morala André , Banks William E , Lenoble Arnaud 
Published: July 2020

ABSTRACTDiscovered at the beginning of the twentieth century, the Abri Casserole (Dordogne, France) was the subject of salvage excavations in the early nineties. The fieldwork revealed a sequence of 13 archaeological levels that document human occupations from the Gravettian to the Magdalenian, including very rare and poorly known assemblages (e.g. Early Badegoulian, Protosolutrean) that afford a particular importance to this sequence. Results of a previous dating program that focused on the Badegoulian levels were obtained in 1994 but were neither extensively published nor discussed. Five AMS14C ages obtained for the Gravettian and Solutrean assemblages in the early 2010s served to complement the site’s chronology. However, since the beta counting ages for the Badegoulian levels were in conflict with the accepted AMS chronology for the region’s late Pleniglacial archaeological record, a new AMS dating program was implemented to renew the radiometric framework of this specific portion of the sequence. Compared to the previous beta counting measurements, the seven newly obtained AMS ages are about 1000 years older (23.3–20.5 cal ka BP) and congruent with other AMS-dated Badegoulian sequences. These results thereby restore the inter-site chronological coherence of the Solutrean–Badegoulian and Badegoulian–Magdalenian transitions.
The processing of object–subject ambiguities in early second-language acquirers
Authors: Berghoff Robyn 
Published: July 2020

AbstractStudies of the second language (L2) processing of object–subject ambiguities (OSA), where the parser must revise an initially incorrect analysis of the input, have yielded two findings that the present paper addresses. First, L2 speakers are guided more strongly by plausibility information than L1 speakers in OSA processing. Second, L2 speakers generally do not perform reanalysis in real time, and their comparably poor performance on subsequent comprehension questions suggests ultimate failure to derive a grammatical parse. Because previous studies have targeted later L2 acquirers living outside of an L2 context, the present study tested whether the above two findings hold for childhood L2 acquirers with extensive naturalistic L2 exposure, hypothesizing that these factors would engender more nativelike processing. A self-paced reading task involving two kinds of OSA construction was conducted. Sensitivity to plausibility information differed across the first language and L2 groups per construction type. Within the L2 group, there is evidence that the early childhood acquirers initiated online reanalysis. Comprehension question accuracy did not differ across participant groups, suggesting that all participants succeeded in reanalysis to the same extent. The role of age of onset in L2 processing is discussed, as is the findings’ relevance to current models of L2 processing.
There and Back Again: The Selectivity of Recidivism in Belgian Prisons
Authors: Depauw Ewout 
Published: July 2020

AbstractThe “panoptic” powers characteristic of nineteenth-century criminal justice systems created prison sources that are increasingly used to study past populations. Each step of the criminal process has its own selection logic, leading to a predominance of unskilled and low-skilled men and women in prison samples. There are also crucial differences between the profiles of single and repeat offenders. This article employs a sample of more than 27,000 individual admissions to Belgian prisons in the nineteenth century to explore these trends in greater depth. Recidivists form a specific subset of the prison population. Detailed comparisons of recidivists and nonrecidivists are therefore useful as they help to understand the selection mechanisms inherent in prison data. Male recidivists were predominately low-waged workers incarcerated for minor acts of violence or misconduct classified as disturbances of the peace. Female recidivists were disproportionately low-skilled workers arrested for beggary and sex work. Recidivists also differed in their stature. Male recidivists in Belgian prisons were shorter than the average prisoner. By contrast, female recidivists were taller than one-time offenders. These height differences have important implications for our understanding of well-being in the past.
Enhanced Predictability of Eastern North Pacific Tropical Cyclone Activity Using the ENSO Longitude Index
Authors: Balaguru Karthik , Patricola Christina M. , Hagos Samson M. , Leung L. Ruby , Dong Lu 
Published: July 2020

AbstractWhile El Niño–Southern Oscillation (ENSO) influences eastern North Pacific (ENP) tropical cyclones (TCs) through a variety of atmospheric processes when examined concurrently, ocean pathways dominate at longer lead times. The eastward displacement of the warm pool during an El Niño, which carries warm water into the ENP basin, is the primary oceanic mechanism. Despite this, the question of whether an accurate knowledge of preseason ENSO conditions enhances predictability of ENP TCs has not been addressed specifically. In this study, we show that relative to traditional indices of ENSO, the ENSO Longitude Index (ELI) captures changes in the location of deep convection and associated thermocline processes more accurately. Consequently, the ELI explains more variability in the upper‐ocean heat content, and thus TC activity, at lead times of several months in the ENP basin. These results motivate the need to further explore the predictability of ENP TCs associated with ENSO.
Exploring and modelling colon cancer inter-tumour heterogeneity: opportunities and challenges
Authors: Buikhuisen Joyce Y. , Torang Arezo , Medema Jan Paul 
Published: July 2020

AbstractColon cancer inter-tumour heterogeneity is installed on multiple levels, ranging from (epi)genetic driver events to signalling pathway rewiring reflected by differential gene expression patterns. Although the existence of heterogeneity in colon cancer has been recognised for a longer period of time, it is sparingly incorporated as a determining factor in current clinical practice. Here we describe how unsupervised gene expression-based classification efforts, amongst which the consensus molecular subtypes (CMS), can stratify patients in biological subgroups associated with distinct disease outcome and responses to therapy. We will discuss what is needed to extend these subtyping efforts to the clinic and we will argue that preclinical models recapitulate CMS subtypes and can be of vital use to increase our understanding of treatment response and resistance and to discover novel targets for therapy.
BEaTS-α an open access 3D printed device for in vitro electromechanical stimulation of human induced pluripotent stem cells
Authors: Cortes David , McTiernan Christopher D. , Ruel Marc , Franco Walfre , Chu Cencen , Liang Wenbin , Suuronen Erik J. , Alarcon Emilio I. 
Published: July 2020

Abstract3D printing was used to develop an open access device capable of simultaneous electrical and mechanical stimulation of human induced pluripotent stem cells in 6-well plates. The device was designed using Computer-Aided Design (CAD) and 3D printed with autoclavable, FDA-approved materials. The compact design of the device and materials selection allows for its use inside cell incubators working at high humidity without the risk of overheating or corrosion. Mechanical stimulation of cells was carried out through the cyclic deflection of flexible, translucent silicone membranes by means of a vacuum-controlled, open-access device. A rhythmic stimulation cycle was programmed to create a more physiologically relevant in vitro model. This mechanical stimulation was coupled and synchronized with in situ electrical stimuli. We assessed the capabilities of our device to support cardiac myocytes derived from human induced pluripotent stem cells, confirming that cells cultured under electromechanical stimulation presented a defined/mature cardiomyocyte phenotype. This 3D printed device provides a unique high-throughput in vitro system that combines both mechanical and electrical stimulation, and as such, we foresee it finding applications in the study of any electrically responsive tissue such as muscles and nerves.
Object detection based on an adaptive attention mechanism
Authors: Li Wei , Liu Kai , Zhang Lizhe , Cheng Fei 
Published: July 2020

AbstractObject detection is an important component of computer vision. Most of the recent successful object detection methods are based on convolutional neural networks (CNNs). To improve the performance of these networks, researchers have designed many different architectures. They found that the CNN performance benefits from carefully increasing the depth and width of their structures with respect to the spatial dimension. Some researchers have exploited the cardinality dimension. Others have found that skip and dense connections were also of benefit to performance. Recently, attention mechanisms on the channel dimension have gained popularity with researchers. Global average pooling is used in SENet to generate the input feature vector of the channel-wise attention unit. In this work, we argue that channel-wise attention can benefit from both global average pooling and global max pooling. We designed three novel attention units, namely, an adaptive channel-wise attention unit, an adaptive spatial-wise attention unit and an adaptive domain attention unit, to improve the performance of a CNN. Instead of concatenating the output of the two attention vectors generated by the two channel-wise attention sub-units, we weight the two attention vectors based on the output data of the two channel-wise attention sub-units. We integrated the proposed mechanism with the YOLOv3 and MobileNetv2 framework and tested the proposed network on the KITTI and Pascal VOC datasets. The experimental results show that YOLOv3 with the proposed attention mechanism outperforms the original YOLOv3 by mAP values of 2.9 and 1.2% on the KITTI and Pascal VOC datasets, respectively. MobileNetv2 with the proposed attention mechanism outperforms the original MobileNetv2 by a mAP value of 1.7% on the Pascal VOC dataset.
Open software platform for automated analysis of paper-based microfluidic devices
Authors: Parker Rayleigh W. , Wilson Daniel J. , Mace Charles R. 
Published: July 2020

AbstractDevelopment of paper-based microfluidic devices that perform colorimetric measurements requires quantitative image analysis. Because the design geometries of paper-based microfluidic devices are not standardized, conventional methods for performing batch measurements of regularly spaced areas of signal intensity, such as those for well plates, cannot be used to quantify signal from most of these devices. To streamline the device development process, we have developed an open-source program called ColorScan that can automatically recognize and measure signal-containing zones from images of devices, regardless of output zone geometry or spatial arrangement. This program, which measures color intensity with the same accuracy as standard manual approaches, can rapidly process scanned device images, simultaneously measure identified output zones, and effectively manage measurement results to eliminate requirements for time-consuming and user-dependent image processing procedures.
Molecular and cellular correlates in Kv channel clustering: entropy-based regulation of cluster ion channel density
Authors: Lewin Limor , Nsasra Esraa , Golbary Ella , Hadad Uzi , Orr Irit , Yifrach Ofer 
Published: July 2020

AbstractScaffold protein-mediated ion channel clustering at unique membrane sites is important for electrical signaling. Yet, the mechanism(s) by which scaffold protein-ion channel interactions lead to channel clustering or how cluster ion channel density is regulated is mostly not known. The voltage-activated potassium channel (Kv) represents an excellent model to address these questions as the mechanism underlying its interaction with the post-synaptic density 95 (PSD-95) scaffold protein is known to be controlled by the length of the extended ‘ball and chain’ sequence comprising the C-terminal channel region. Here, using sub-diffraction high-resolution imaging microscopy, we show that Kv channel ‘chain’ length regulates Kv channel density with a ‘bell’-shaped dependence, reflecting a balance between thermodynamic considerations controlling ‘chain’ recruitment by PSD-95 and steric hindrance due to the spatial proximity of multiple channel molecules. Our results thus reveal an entropy-based mode of channel cluster density regulation that mirrors the entropy-based regulation of the Kv channel-PSD-95 interaction. The implications of these findings for electrical signaling are discussed.
Adult pancreatoblastoma: clinical features and Imaging findings
Authors: Zhang Xi , Ni Shu-juan , Wang Xiao-hong , Huang Dan , Tang Wei 
Published: July 2020

AbstractThe objective of this study was to illustrate the clinical, CT, MRI, and18F-FDG PET/CT features of adult pancreatoblastoma, an extremely rare disease. In this study, the clinical and imaging features of seven adult patients with pathologically confirmed pancreatoblastoma were retrospectively analyzed. The following parameters were evaluated: size, location, shape, margination, solid-cystic ratio, CT attenuation values or signal intensity and contrast enhancement pattern. We also analyzed whether abnormal FDG uptake occurred during18F-FDG PET/CT imaging. All seven patients were male (mean age 45 years; range 22–65 years). Six tumors were irregular in shape, exogenous, and grew outward from the pancreatic parenchyma, similar to branches growing from a tree trunk (85.7%). The tumor margins were clear in five patients (71.4%), and three tumors (42.9%) were encapsulated. Six tumors (71.4%) were solid, with homogeneous enhancement observed on contrast-enhanced CT and MRI. Dynamic-enhanced CT and MRI showed progressive enhancement for all tumors. On18F-FDG PET/CT, one tumor exhibited abnormal FDG uptake, and two tumors exhibited no abnormal uptake (66.7%). In conclusion, adult pancreatoblastoma most commonly occurs in male patients, and it usually appears as an exophytic, irregular, and hypovascular mass with well-defined margins and progressive enhancement on CT and MRI. This type of tumor always grows out of the parenchyma of the pancreas, similar to branches growing outward from a tree trunk.
Aggregation tendency of guest Fe in NaCo1−xFexO2 (x < 0.1) as investigated by systematic EXAFS analysis
Authors: Moriya Toshiaki , Niwa Hideharu , Nitani Hiroaki , Moritomo Yutaka 
Published: July 2020

AbstractIn transition metal (M) compounds, the partial substitution of the host transition metal (Mh) to guest one (Mg) is effective to improve the functionality. To microscopically comprehend the substitution effect, degree of distribution of Mg is crucial. Here, we propose that a systematic EXAFS analysis against the Mg concentration can reveal the spatial distribution of Mg. We chose NaCo1−xFexO2 as a prototypical M compound and investigated the local intermetal distance around the guest Fe [dFe–M(x)] against Fe concentration (x). dFe–M(x) steeply increased with x, reflecting the larger ionic radius of high-spin Fe3+. The x-dependence of dFe–M(x) was analyzed by an empirical equation, $${d}_{\mathrm{F}\mathrm{e}-M}(x)=sxd_{\mathrm{F}\mathrm{e}-\mathrm{F}\mathrm{e}}+(1-sx)d_{\mathrm{F}\mathrm{e}-\mathrm{C}\mathrm{o}}$$dFe-M(x)=sxdFe-Fe+(1-sx)dFe-Co, where dFe–Fe and dFe–Co are the Fe–Fe and Co–Fe distances, respectively. The parameter s represents degree of distribution of Fe; s = 1, > 1, < 1 are for random, attractive, and repulsive distribution, respectively. The obtained s value (= 4.8) indicates aggregation tendency of guest Fe.
Soil labile organic carbon fractions and soil enzyme activities after 10 years of continuous fertilization and wheat residue incorporation
Authors: Zhang Ligan , Chen Xi , Xu Yujun , Jin Mengcan , Ye Xinxin , Gao Hongjian , Chu Wenying , Mao Jingdong , Thompson Michael L. 
Published: July 2020

AbstractLabile organic carbon (LOC) fractions and related enzyme activities in soils are considered to be early and sensitive indicators of soil quality changes. We investigated the influences of fertilization and residue incorporation on LOC fractions, enzyme activities, and the carbon pool management index (CPMI) in a 10-year field experiment. The experiment was composed of three treatments: (1) no fertilization (control), (2) chemical fertilizer application alone (F), and (3) chemical fertilizer application combined with incorporation of wheat straw residues (F + R). Generally, the F + R treatment led to the highest concentrations of the LOC fractions. Compared to the control treatment, the F + R treatment markedly enhanced potential activities of cellulase (CL), β-glucosidase (BG), lignin peroxidase (LiP), and manganese peroxidase (MnP), but decreased laccase (LA) potential activity. Partial least squares regression analysis suggested that BG and MnP activities had a positive impact on the light-fraction organic carbon (LFOC), permanganate-oxidizable carbon (POXC), and dissolved organic carbon (DOC) fractions, whereas laccase activity had a negative correlation with those fractions. In addition, the F + R treatment significantly increased the CPMI compared to the F and control treatments. These results indicated that combining fertilization with crop residues stimulates production of LOC and could be a useful approach for maintaining sustainable production capacity in lime concretion black soils along the Huai River region of China.
Polymerized human hemoglobin facilitated modulation of tumor oxygenation is dependent on tumor oxygenation status and oxygen affinity of the hemoglobin-based oxygen carrier
Authors: Belcher Donald A. , Lucas Alfredo , Cabrales Pedro , Palmer Andre F. 
Published: July 2020

AbstractAdministration of hemoglobin-based oxygen carriers (HBOCs) into the systemic circulation is a potential strategy to relieve solid tumor hypoxia in order to increase the effectiveness of chemotherapeutics. Previous computational analysis indicated that the oxygen (O2) status of the tumor and HBOC O2 affinity may play a role in increased O2 delivery to the tumor. However, no study has experimentally investigated how low- and high-affinity HBOCs would perform in normoxic and hypoxic tumors. In this study, we examined how the HBOC, polymerized human hemoglobin (PolyhHb), in the relaxed (R) or tense (T) quaternary state modulates O2 delivery to hypoxic (FME) and normoxic (LOX) human melanoma xenografts in a murine window chamber model. We examined microcirculatory fluid flow via video shearing optical microscopy, and O2 distributions via phosphorescence quenching microscopy. Additionally, we examined how weekly infusion of a 20% top-load dose of PolyhHb influences growth rate, vascularization, and regional blood flow in the FME and LOX tumor xenografts. Infusion of low-affinity T-state PolyhHb led to increased tissue oxygenation, decreased blood flow, decreased tumor growth, and decreased vascularization in hypoxic tumors. However, infusion of both T-state and R-state PolyhHbs led to worse outcomes in normoxic tumors. Of particular concern was the high-affinity R-state PolyhHb, which led to no improvement in hypoxic tumors and significantly worsened outcomes in normoxic tumors. Taken together, the results of this study indicate that the tumor O2 status is a primary determinant of the potency and outcomes of infused PolyhHb.
Fossils reshape the Sternorrhyncha evolutionary tree (Insecta, Hemiptera)
Authors: Drohojowska Jowita , Szwedo Jacek , Żyła Dagmara , Huang Di-Ying , Müller Patrick 
Published: July 2020

AbstractThe Sternorrhyncha, which comprise about 18,700 described recent species, is a suborder of the Hemiptera, one of big five most diverse insect orders. In the modern fauna, these tiny phytophages comprise insects of great ecological and economic importance, like aphids (Aphidomorpha), scale insects (Coccidomorpha), whiteflies (Aleyrodomorpha) and psyllids (Psylloidea). Their evolutionary history can be traced back to the Late Carboniferous, but the early stages of their evolution and diversification is poorly understood, with two known extinct groups—Pincombeomorpha and Naibiomorpha variously placed in classifications and relationships hypotheses. Most of the recent Sternorrhyncha groups radiated rapidly during the Cretaceous. Here we report the new finding of very specialised sternorrhynchans found as inclusions in mid-Cretaceous amber from Kachin state (northern Myanmar), which represent another extinct lineage within this hemipteran suborder. These fossils, proposed to be placed in a new infraorder, are revealed to be related to whiteflies and psyllids. We present, also for the first time, the results of phylogenetic analyses covering extinct and extant lineages of the Sternorrhyncha.