bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of a modified group cognitive behavioral therapy program for anxiety in children with ASD delivered in a community context
Authors: Solish Abbie , Klemencic Nora , Ritzema Anne , Nolan Vicki , Pilkington Martha , Anagnostou Evdokia , Brian Jessica 
Published: May 2020

AbstractBackgroundYouth with autism spectrum disorder (ASD) experience high rates (approximately 50–79%) of comorbid anxiety problems. Given the significant interference and distress that excessive anxiety can cause, evidence-based intervention is necessary in order to reduce long-term negative effects. Cognitive behavioral therapy (CBT) has demonstrated efficacy for treating anxiety disorders across the lifespan, both in individual and group formats. Recently, modified CBT programs for youth with ASD have been developed, showing positive outcomes. To date, these modified CBT programs have primarily been evaluated in controlled research settings.MethodsThe current community effectiveness study investigated the effectiveness of a modified group CBT program (Facing Your Fears) delivered in a tertiary care hospital and across six community-based agencies providing services for youth with ASD. Data were collected over six years (N= 105 youth with ASD; ages 6–15 years).ResultsHospital and community samples did not differ significantly, except in terms of age (hospitalM= 10.08 years; communityM= 10.87 years). Results indicated significant improvements in anxiety levels from baseline to post-treatment across measures, with medium effect sizes. An attempt to uncover individual characteristics that predict response to treatment was unsuccessful.ConclusionsOverall, this study demonstrated that community implementation of a modified group CBT program for youth with ASD is feasible and effective for treating elevated anxiety.
Quantitative prediction of selectivity between the A1 and A2A adenosine receptors
Authors: Burggraaff Lindsey , van Vlijmen Herman W. T. , IJzerman Adriaan P. , van Westen Gerard J. P. 
Published: May 2020

AbstractThe development of drugs is often hampered due to off-target interactions leading to adverse effects. Therefore, computational methods to assess the selectivity of ligands are of high interest. Currently, selectivity is often deduced from bioactivity predictions of a ligand for multiple targets (individual machine learning models). Here we show that modeling selectivity directly, by using the affinity difference between two drug targets as output value, leads to more accurate selectivity predictions. We test multiple approaches on a dataset consisting of ligands for the A1 and A2A adenosine receptors (among others classification, regression, and we define different selectivity classes). Finally, we present a regression model that predicts selectivity between these two drug targets by directly training on the difference in bioactivity, modeling the selectivity-window. The quality of this model was good as shown by the performances for fivefold cross-validation: ROC A1AR-selective 0.88 ± 0.04 and ROC A2AAR-selective 0.80 ± 0.07. To increase the accuracy of this selectivity model even further, inactive compounds were identified and removed prior to selectivity prediction by a combination of statistical models and structure-based docking. As a result, selectivity between the A1 and A2A adenosine receptors was predicted effectively using the selectivity-window model. The approach presented here can be readily applied to other selectivity cases.
Proteomic analysis revealed T cell hyporesponsiveness induced by Haemonchus contortus excretory and secretory proteins
Authors: Lu Mingmin , Tian Xiaowei , Yang Zhang , Wang Wenjuan , Tian Ai-Ling , Li Charles , Yan Ruofeng , Xu Lixin , Song Xiaokai , Li Xiangrui 
Published: May 2020

AbstractHaemonchus contortus has evolved highly integrated and sophisticated mechanisms to promote coexistence with hosts. The excretory-secretory (ES) products generated by this parasite contribute to the regulation of the host immune response to facilitate immune evasion and induce chronicity, but the proteins responsible for this process and the exact cellular mechanisms have yet to be defined. In this study, we identified 114 H. contortus ES proteins (HcESPs) interacting with host T cells and 15 T cell binding receptors via co-immunoprecipitation and shotgun liquid chromatography-tandem mass spectrometry analysis. Based on bioinformatics analysis, we demonstrated that HcESPs could inhibit T cell viability, induce cell apoptosis, suppress T cell proliferation and cause cell cycle arrest. Furthermore, the stimulation of HcESPs exerted critical control effects on T cell cytokine production profiles, predominantly promoting the secretion of interleukin (IL)-10, IL-17A and transforming growth factor-β1 and inhibiting IL-2, IL-4 and interferon-γ production. Collectively, these findings may provide insights into the interaction between ES proteins and key host effector cells, enhancing our understanding of the molecular mechanism underlying parasite immune evasion and providing new clues for novel vaccine development.
Stability analysis by fixed point theorems for a class of non-linear Caputo nabla fractional difference equation
Authors: Butt Rabia Ilyas , Abdeljawad Thabet , ur Rehman Mujeeb 
Published: May 2020

AbstractFractional difference equations have become important due to their qualitative properties and applications in discrete modeling. Stability analysis of solutions is one of the most widely used qualitative properties with tremendous applications. In this paper, we investigate the existence and stability results for a class of non-linear Caputo nabla fractional difference equations. To obtain the existence and stability results, we use Schauder’s fixed point theorem, the Banach contraction principle and Krasnoselskii’s fixed point theorem. The analysis of the theoretical results depends on the structure of nabla discrete Mittag-Leffler functions. An example is provided to illustrate the theoretical results.
Chaotic triopoly game: a congestion case
Authors: Askar S. S. , Al-khedhairi A. 
Published: May 2020

AbstractIn this paper, we propose a simple network consisting of only two nodes and two paths. The first node, which is called the source, has three competing firms that send their quantities of load via the two paths to the second node, called the destination node. The static game that describes the reaction among the three firms is constructed. The Nash equilibrium point of the static game is discussed. Assuming a gradient firm based rule we investigate the dynamic game which has the same Nash equilibrium as in the static game. The local stability conditions of the Nash equilibrium are obtained in terms of the reactivity parameters among the firms and the nonlinear costs functions adopted by those firms. The obtained results are supported by a numerical simulation that in turn gives routes where Nash equilibrium may lose its stability. The simulation shows that Nash equilibrium loses its stability via flip and fold bifurcations and then chaos exists.
Determinants of prebiotic vegetable consumption: the extended theory of planned behaviour
Authors: Broers V. J. V. , Van den Broucke S. , Luminet O. 
Published: May 2020

Abstract
Background
Prebiotic vegetables such as leek and salsify may contribute to preventing obesity by changing the composition of the gut microbiota. To increase consumption of prebiotic vegetables, the aim of the study was to document the prevalence and determinants of (prebiotic) vegetable consumption.

Methods
An online, correlational questionnaire was administered to participants using a mixed approach (1078 online, 200 face-to-face). Participants were a representative sample (gender, age, level of education, province, population density and (un)employment) of 1278 adults of the Walloon region in Belgium. The frequency and determinants of prebiotic vegetable consumption were measured using an extension of the Theory of Planned Behaviour including habits, actual control and compensatory health beliefs. Descriptive analyses were performed followed by hierarchic multiple regression analyses.

Results
The descriptive results showed that for all categories (leek, salsify, vegetables in general) an improvement in both intentions and prevalence of the actual behaviour is necessary to experience the health benefits of (prebiotic) vegetables. Intentions and habits were important predictors of consumption for all types of vegetables, and hedonic attitudes and subjective norms were important predictors of intention. Perceived control and rational attitudes were predictors of intention to consume only for vegetables in general. Finally, environmental factors such as price, availability and actual control predict consumption but their influence differs depending on the vegetable.

Conclusions
The findings can be used to inform interventions that aim to increase (prebiotic) vegetable consumption. Umbrella terms such as ‘healthy food’ or ‘vegetables’ do not capture the differences between the specific foods regarding the demographic and socio-psychological determinants of their consumption. This is the first research to investigate the determinants of prebiotic vegetable consumption.
A comparison of bone conductivity on titanium screws inserted into the vertebra using different surface processing
Authors: Ota Takashi , Demura Satoru , Kato Satoshi , Yoshioka Katsuhito , Hayashi Hiroyuki , Inoue Kei , Shinmura Kazuya , Yokogawa Noriaki , Shirai Toshiharu , Murakami Hideki , Tsuchiya Hiroyuki 
Published: May 2020

Abstract
Purpose
Antibacterial iodine-supported titanium has an anodized oxide layer; thus, it can be expected to have a higher osteoconductivity than untreated titanium. This study aimed to compare the osteoconductivity between untreated titanium (Ti), anodically oxidized titanium (AO-Ti), and iodine-supported titanium (I-Ti) screws.

Methods
The screws were inserted into the vertebral bodies of 30 dogs (12 for the biomechanical, and 18 for the histological examination). The vertebral bodies were analyzed at 4 or 8 weeks after screw insertion. Biomechanically, rotational torque of the screw was measured. Histologically, bone formation index (ratio of the length of the part where the bone directly contacts with the length of the screw) and bone volume density (ratio of the area of the bone tissue to the area between the threads of the screw) were measured.

Result
At 4 weeks, the torque value was significantly higher in the AO-Ti (0.59 ± 0.16 Nm) and I-Ti (0.72 ± 0.14 Nm) groups than in the Ti group (0.39 ± 0.12 Nm), with the AO-Ti and I-Ti groups showing no significant difference. Bone formation index was significantly higher in the AO-Ti (72.5% ± 0.8%) and I-Ti (73.4% ± 1.5%) groups than in the Ti group (64.6% ±1.7%), with the AO-Ti and I-Ti groups showing no significant difference. Bone volume density did not show a significant difference. At 8 weeks, the results were similar to those at 4 weeks.

Conclusions
I-Ti had a higher osteoconductivity than Ti, indicating that iodine coating did not adversely affect osteoconductivity.
Robust Continuous-Flow Synthesis of Deuterium-Labeled β-Nitroalcohols Catalyzed by Basic Anion Exchange Resin
Authors: Yamada Tsuyoshi , Park Kwihwan , Ito Naoya , Masuda Hayato , Teranishi Wataru , Cui Sunliang , Sajiki Hironao 
Published: May 2020

Abstract
A practical and efficient continuous-flow system was developed for the synthesis of site-selectively deuterium-labeled β-nitroalcohols by using the tertiary amine-functionalized basic anion exchange resin, WA30, as a heterogeneous organocatalyst. For this system, WA30 was prepacked in a cartridge under metal-free conditions. The system was operated by pumping a solution of aldehydes or ketones, as electrophiles, and nitroalkanes in a solvent system of deuterium oxide and THF in the catalyst cartridge. Various deuterated β-nitroalcohols were obtained in moderate to excellent yields with high deuteration efficiencies. The continuous-flow system was applied in continuous synthesis for at least 72 h without degradation of the heterogeneous organocatalyst activity.
Adsorption Behavior of Mono-Cationic Pyridinium Salts on the Clay Surface
Authors: Takigawa Tomoaki , Yoshida Yuma , Fujimura Takuya , Ishida Tamao , Shimada Tetsuya , Takagi Shinsuke 
Published: May 2020

Abstract
The adsorption behavior of cationic organic molecules was examined on a clay surface. Systematically chosen pyridinium salts and artificially synthesized anionic clay were used. The adsorption equilibrium constants and the free energy for adsorption (ΔG) values were obtained for each pyridinium salt. It was discovered that ΔG values were proportional to the cross-sectional area of the pyridinium salt. These results indicate that hydrophobic and/or van der Waals interactions play an important role for the adsorption process.
Macroporous Silica Microcapsules Immobilizing Esterase with High Hydrolysis Reactivity
Authors: Fujiwara Masahiro , Shoji Shigeru , Murakami Yuka , Ishikawa Kazuhiko 
Published: May 2020

Abstract
An esterase, 3,4-dihydrocoumarin hydrolase, was directly immobilized into silica microcapsules. The hydrolysis reaction of 3,4-dihydrocoumarin by a macroporous silica microcapsule immobilizing the esterase was faster than those by mesoporous ones. Using this macroporous microcapsule, the hydrolysis reaction of p-nitrophenyl acetate proceeded with comparable rate to non-immobilized esterase.
Mammography-based radiomics nomogram: a potential biomarker to predict axillary lymph node metastasis in breast cancer
Authors: Tan Hongna , Wu Yaping , Bao Fengchang , Zhou Jing , Wan Jianzhong , Tian Jie , Lin Yusong , Wang Meiyun 
Published: May 2020

Objective:
To establish a radiomics nomogram by integrating clinical risk factors and radiomics features extracted from digital mammography (MG) images for pre-operative prediction of axillary lymph node (ALN) metastasis in breast cancer.

Methods:
216 patients with breast cancer lesions confirmed by surgical excision pathology were divided into the primary cohort (n = 144) and validation cohort (n = 72). Radiomics features were extracted from craniocaudal (CC) view of mammograms, and radiomics features selection were performed using the methods of ANOVA F-value and least absolute shrinkage and selection operator; then a radiomics signature was constructed with the method of support vector machine. Multivariate logistic regression analysis was used to establish a radiomics nomogram based on the combination of radiomics signature and clinical factors. The C-index and calibration curves were derived based on the regression analysis both in the primary and validation cohorts.

Results:
95 of 216 patients were confirmed with ALN metastasis by pathology, and 52 cases were diagnosed as ALN metastasis based on MG-reported criteria. The sensitivity, specificity, accuracy and AUC (area under the receiver operating characteristic curve of MG-reported criteria were 42.7%, 90.8%, 24.1% and 0.666 (95% confidence interval: 0.591–0.741]. The radiomics nomogram, comprising progesterone receptor status, molecular subtype and radiomics signature, showed good calibration and better favorite performance for the metastatic ALN detection (AUC 0.883 and 0.863 in the primary and validation cohorts) than each independent clinical features (AUC 0.707 and 0.657 in the primary and validation cohorts) and radiomics signature (AUC 0.876 and 0.862 in the primary and validation cohorts).

Conclusion:
The MG-based radiomics nomogram could be used as a non-invasive and reliable tool in predicting ALN metastasis and may facilitate to assist clinicians for pre-operative decision-making.

Advances in knowledge:
ALN status remains among the most important breast cancer prognostic factors and is essential for making treatment decisions. However, the value of detecting metastatic ALN by MG is very limited. The studies on pre-operative ALN metastasis prediction using the method of MG-based radiomics in breast cancer are very few. Therefore, we studied whether MG-based radiomics nomogram could be used as a predictive biomarker for the detection of metastatic ALN.
Nuclear medicine and molecular imaging advances in the 21st century
Authors: Vaz Sofia C. , Oliveira Francisco , Herrmann Ken , Veit-Haibach Patrick 
Published: May 2020

Currently, Nuclear Medicine has a clearly defined role in clinical practice due to its usefulness in many medical disciplines. It provides relevant diagnostic and therapeutic options leading to patients' healthcare and quality of life improvement. During the first two decades of the 21stt century, the number of Nuclear Medicine procedures increased considerably.
Clinical and research advances in Nuclear Medicine and Molecular Imaging have been based on developments in radiopharmaceuticals and equipment, namely, the introduction of multimodality imaging. In addition, new therapeutic applications of radiopharmaceuticals, mainly in oncology, are underway.
This review will focus on radiopharmaceuticals for positron emission tomography (PET), in particular, those labeled with Fluorine-18 and Gallium-68. Multimodality as a key player in clinical practice led to the development of new detector technology and combined efforts to improve resolution. The concept of dual probe (a single molecule labeled with a radionuclide for single photon emission computed tomography)/positron emission tomography and a light emitter for optical imaging) is gaining increasing acceptance, especially in minimally invasive radioguided surgery. The expansion of theranostics, using the same molecule for diagnosis (γ or positron emitter) and therapy (β minus or α emitter) is reshaping personalized medicine.
Upcoming research and development efforts will lead to an even wider array of indications for Nuclear Medicine both in diagnosis and treatment.
ТЕОРЕТИЧЕСКИЕ ПОДХОДЫ К ОПРЕДЕЛЕНИЮ СУЩНОСТИ РЕСУРСНОГО ПОТЕНЦИАЛА В ЭКОНОМИЧЕСКОЙ НАУКЕ
Authors: Baguzova Larisa Valentinovna 
Published: May 2020

В связи с глобальной проблемой ограниченности ресурсов встает вопрос их выполняемости и эффективности использования в любой сфере деятельности. В работе приводятся результаты анализа категорий «ресурсы», «потенциал», «ресурсный потенциал», раскрыты данные понятия в трактовке разных авторов, сформулированы основные выводы о необходимости теоретических исследований в области изучения ресурсного потенциала образовательных организаций высшего образования. Предложено авторское понятие ресурсного потенциала в котором учитывается его целевое назначение. На примере образовательных организаций высшего образования разработана классификация и структура ресурсного потенциала.Цель – изучение ресурсного потенциала с разных точек зрения с выявлением основных его составляющих.Метод или методология проведения работы: в статье использовались общенаучные подходы теоретического исследования: описание, изложение, анализа и синтеза.Результаты: предложено авторское понятие дефиниции «ресурсный потенциал». В связи с поставленной задачей Президентом в Послании Федеральному Собранию о развитии цифровой экономики, в предложенной классификации выделены виды потенциала необходимые для осуществления образовательного процесса такие как: информационный, информационно-коммуникационный и цифровой.Область применения результатов: проведенные исследования послужат теоретической базой диссертационного исследования эффективности управления ресурсным потенциалом образовательных организаций высшего образования.
DA GEOGRAFIA DA POPULAÇÃO À NECROPOLÍTICA: PRESENTIFICAÇÃO E DISPUTAS DE SENTIDO EM TEMPOS DE CORONAVÍRUS
Authors: Karol Eduardo , Silva Catia Antonia da 
Published: May 2020

O presente artigo tem como desafio analisar o contexto da crise do coronavírus na produção de discursos que fortalecem o pensamento da Necropolítica. A crise do COVID- 19 é planetária. Começou na China e rapidamente se difundiu por mais de 180 países, devido a aceleração da circulação de pessoas na escala mundo. Assim, essa crise ganha a dimensão demográfica que merece reflexão geográfica e sobretudo, a compreensão das narrativas que reafirmam a dimensão político-conservadoras que atrelam a mortalidade da população pobre e negra como positiva para a regulação da economia e superação das desigualdades sociais. Trata-se de um contexto em que a crise acelera a agudização das desigualdades e as formulações de superação de problemas ganham a dimensão de discursos genocidas e de perversidade que põem em xeque os limites da modernidade e da pauta humanista. Assim, mais uma vez a questão demográfica pode ganhar centralidade nesse debate pautado na superação das desigualdades pela negação do outro e pela destruição dos pobres. O artigo divide-se em duas seções: a primeira apresenta os dados disponíveis sobre a expansão do coronavírus e a segunda analisar a revisão bibliográfica que alimenta a necropolítica demográfica
Detecting the presence of bacterial RNA by polymerase chain reaction in low volumes of preoperatively aspirated synovial fluid from prosthetic joint infections
Authors: Yang B. , Fang X. , Cai Y. , Yu Z. , Li W. , Zhang C. , Huang Z. , Zhang W. 
Published: May 2020

Aims Preoperative diagnosis is important for revision surgery after prosthetic joint infection (PJI). The purpose of our study was to determine whether reverse transcription-quantitative polymerase chain reaction (RT-qPCR), which is used to detect bacterial ribosomal RNA (rRNA) preoperatively, can reveal PJI in low volumes of aspirated fluid. Methods We acquired joint fluid samples (JFSs) by preoperative aspiration from patients who were suspected of having a PJI and failed arthroplasty; patients with preoperative JFS volumes less than 5 ml were enrolled. RNA-based polymerase chain reaction (PCR) and bacterial culture were performed, and diagnostic efficiency was compared between the two methods.According to established Musculoskeletal Infection Society (MSIS) criteria, 21 of the 33 included patients were diagnosed with PJI. Results RNA-based PCR exhibited 57.1% sensitivity, 91.7% specificity, 69.7% accuracy, 92.3% positive predictive value, and 55.0% negative predictive value. The corresponding values for culture were 28.6%, 83.3%, 48.5%, 75.0%, and 40.0%, respectively. A significantly higher sensitivity was thus obtained with the PCR method versus the culture method. Conclusion In situations in which only a small JFS volume can be acquired, RNA-based PCR analysis increases the utility of preoperative puncture for patients who require revision surgery due to suspected PJI. Cite this article: Bone Joint Res. 2020;9(5):219–224.
Low-loss fiber-to-chip interface for lithium niobate photonic integrated circuits
Authors: He Lingyan , Zhang Mian , Shams-Ansari Amirhassan , Zhu Rongrong , Wang Cheng , Marko Lončar 
Published: May 2020

Integrated lithium niobate (LN) photonic circuits have recently emerged as a promising candidate for advanced photonic functions such as high-speed modulation, nonlinear frequency conversion, and frequency comb generation. For practical applications, optical interfaces that feature low fiber-to-chip coupling losses are essential. So far, the fiber-to-chip loss (commonly

>
10

dB
/
facet

) has dominated the total insertion losses of typical LN photonic integrated circuits, where on-chip losses can be as low as 0.03–0.1 dB/cm. Here we experimentally demonstrate a low-loss mode size converter for coupling between a standard lensed fiber and sub-micrometer LN rib waveguides. The coupler consists of two inverse tapers that convert the small optical mode of a rib waveguide into a symmetrically guided mode of a LN nanowire, featuring a larger mode area matched to that of a tapered optical fiber. The measured fiber-to-chip coupling loss is lower than 1.7 dB/facet with high fabrication tolerance and repeatability. Our results open the door for practical integrated LN photonic circuits efficiently interfaced with optical fibers.