bluuebunny/crossref_metadata_2025_split huggingface dataset:
A set theory based similarity measure for text clustering and classification
Authors: Amer Ali A. , Abdalla Hassan I. 
Published: September 2020

AbstractSimilarity measures have long been utilized in information retrieval and machine learning domains for multi-purposes including text retrieval, text clustering, text summarization, plagiarism detection, and several other text-processing applications. However, the problem with these measures is that, until recently, there has never been one single measure recorded to be highly effective and efficient at the same time. Thus, the quest for an efficient and effective similarity measure is still an open-ended challenge. This study, in consequence, introduces a new highly-effective and time-efficient similarity measure for text clustering and classification. Furthermore, the study aims to provide a comprehensive scrutinization for seven of the most widely used similarity measures, mainly concerning their effectiveness and efficiency. Using the K-nearest neighbor algorithm (KNN) for classification, the K-means algorithm for clustering, and the bag of word (BoW) model for feature selection, all similarity measures are carefully examined in detail. The experimental evaluation has been made on two of the most popular datasets, namely, Reuters-21 and Web-KB. The obtained results confirm that the proposed set theory-based similarity measure (STB-SM), as a pre-eminent measure, outweighs all state-of-art measures significantly with regards to both effectiveness and efficiency.
Visualization of the morphology and mode of occurrence of Cenomanian rudists within a drillcore by X-ray CT scanning and 3D modeling
Authors: Yamanaka Motoyoshi , Sano Shin-ichi , Al Zaabi Hamad Bu Alrougha , Fujioka Hiroshi , Iryu Yasufumi 
Published: September 2020

AbstractRudists are a group of bizarrely shaped marine bivalves that lived in the Tethys Ocean from the Late Jurassic to the latest Cretaceous. They are morphologically variable, including snail-like, cup-like, and horn-like shapes. In the Middle East, Cretaceous carbonates with rudists and rudist fragments are well exposed in many outcrops as well as oil and gas fields. For rudist-bearing carbonates in the subsurface, knowledge of rudist morphology and mode of occurrence must be derived from observation of drillcores; however, understanding the three-dimensional (3D) geometry of rudists from observation of core surfaces is difficult. In paleontological studies of rudists, X-ray computerized tomography (CT) scans have been carried out to reconstruct the inside texture of rudist shells for the purpose of taxonomic research. In contrast, in the oil and gas industry, application of X-ray CT scanning technology is generally focused on direct measurement of reservoir properties. Studies of rudist fossils within drillcores by means of X-ray CT have not yet been conducted. We have developed a new protocol to observe core interiors using X-ray CT. We obtained high-resolution 3D images of rudists in a drillcore by means of surface rendering, volume rendering, and 3D printing. X-ray CT and 3D modeling is a novel method for non-destructive analyses of the morphology and mode of occurrence of fossils within drillcores.
Implant-supported orbital prosthesis: a technical innovation of silicone fabrication
Authors: Eo Mi Young , Cho Yun Ju , Nguyen Truc Thi Hoang , Seo Mi Hyun , Kim Soung Min 
Published: September 2020

Abstract
Background
Silicone-based facial prostheses have traditionally been considered difficult to make and require time-consuming fabrication due to their basic liquid characteristics.

Methods and results
A detailed procedure for creating an ideal silicone orbital prosthesis was developed, including dental implant-supported retention, three-dimensional (3D) orbital scanning with symmetric volume and size measurement based on matching the opposite side, master mold fabrication for convenient pouring of the liquid silicone elastomer, and easy and comfortable management of the prosthesis by the patient.

Conclusion
A silicone orbital prosthesis could be more easily and conveniently produced using updated surgical skills and modern 3D technology. The combination of 3D scanning with digital reconstruction and an innovative fabrication protocol using a reproducible major mold and multiple prototypes fitting resulted in an accuracy personalized facial prosthesis with accessible cost and short production period.
Acute myocardial infarction caused by tumor embolus originating from upper tract urothelial carcinoma: a case report
Authors: Yasui Taku , Okuda Yohei , Shioyama Wataru , Oka Toru , Nishikawa Tatsuya , Kamada Risa , Hatano Koji , Nishimura Kazuo , Fujita Masashi 
Published: September 2020

AbstractCoronary emboli from malignant tumors rarely cause acute myocardial infarction. We report the case of a patient with tumor embolism from an upper tract urothelial carcinoma that caused acute myocardial infarction via a patent foramen ovale. Coronary blood flow was restored by embolus aspiration without stenting. Clinicians must consider malignant tumor embolism as a possible cause of acute myocardial infarction.
The preservation and augmentation of volatile terpenes in cannabis inflorescence
Authors: Bueno Justin , Leuer Emily , Kearney Michael , Green Edward H. , Greenbaum Eric A. 
Published: September 2020

Abstract
Background
Terpenes contribute to the pharmacology, efficacy, aroma, and flavor of cannabis inflorescence, improving the experience for medical and recreational users. Terpenes are inherently volatile, resulting in the loss of terpene content as inflorescence ages. A method to establish and/or maintain a desired terpene content of cannabis inflorescence is needed. A novel packaging method was investigated for the preservation of native terpenes and the replenishment of terpenes to depleted inflorescence over various storage durations.

Methods
Inflorescence samples from two different chemotypes (DJ’s Gold, Cream Caramel) were obtained from a state licensed medical cannabis organization. Samples from the DJ’s Gold chemotype were depleted of terpenes whereas samples from the Cream Caramel chemotype had a terpene content representative of inflorescence available for medicinal or recreational purposes. Inflorescence samples were stored using the novel packaging approach, in airtight containers in the presence of external terpenes. Control samples were similarly stored without external terpenes. Terpene content of the inflorescence samples were quantitively determined by headspace gas chromatography mass spectrometry (HS GC-MS) after various storage durations. Main effects analysis was used to determine the impact of various parameters on the effectiveness of the system.

Results
All samples stored using the novel packaging approach had a higher terpene content than their corresponding control. 1.18% (w/w) of external terpene, relative to inflorescence weight, was the minimum amount required to maintain the initial terpene content of the inflorescence after 6 weeks of storage. Main effects analysis showed that augmentation of inflorescence terpene content was dependent upon the amount and type of external volatile utilized. The terpene profile of inflorescence samples from two separate harvests were selectively adjusted, reducing the percent difference of the two sample’s terpene profiles by 39.5%.

Conclusions
A successful proof of concept was achieved for preservation, augmentation, and replenishment of terpenes to cannabis inflorescence over various storage durations. Inflorescence stored using the novel packaging approach is a significant step towards providing patients with cannabis inflorescence of reproducible and reliable terpene content, an important component of inflorescence efficacy. The novel approach for replenishment of terpenes to depleted inflorescence represents an exciting development for patients and manufacturers.
Overview of legal traceability of GPS positioning in Australia
Authors: Hu Guorong , Dawson John 
Published: September 2020

AbstractGlobal Positioning System (GPS) position verification and legal traceability in Australia supports industry, trade, science and innovation and is trusted and recognized domestically and internationally. At the end of 2017, the Australia’s national datum was transitioned from the Geocentric Datum of Australia 1994 (GDA94) to the Geocentric Datum of Australia 2020 (GDA2020). As such, the datum for the legal traceability of GPS positions in Australia has also moved to GDA2020. This paper highlights the importance of legal metrology and measurement in terms of GPS positions in accordance with the National Measurement Act 1960 (Commonwealth of Australia). Here we provide an overview of the process of issuing the so-called ‘Regulation 13 Certificates’ for Continuously Operating Reference Stations (CORS) across Australia. The position verification methodology is detailed, including the quality control, metadata assurance, and dynamic management of the certificates as well as positional uncertainty determination of CORS with varying quality. A quality monitoring system of positions is also discussed along with how measurement traceability is ensured including short-term and long-term position monitoring schemes.
Role of swimming on muscle PGC-1α, FNDC5 mRNA, and assessment of serum omentin, adropin, and irisin in high carbohydrate high fat (HCHF) diet induced obesity in rats
Authors: Badawy Ehsan , El-laithy Nabila A. , Morsy Safaa M. , Ashour Magdi N. , Elias Tahany R. , Masoud Mahmoud M. , Aly Omnia 
Published: September 2020

Abstract
Background
Exercise benefits a variety of organ systems in mammals, and some of the best recognized effects of exercise on muscle are mediated by the transcriptional peroxisome proliferator-activated receptor gamma co-activator 1-α (PGC-1α). The regulatory effect of swimming on muscle PGC-1α, FNDC5 mRNA expression, and subsequently irisin levels is more controversial. This study aimed to investigate the role of swimming as an exercise on the expression of peroxisome proliferator-activated receptor-gamma coactivator1 alpha (PGC-1α) and Fibronectin type III domain containing 5 (FNDC5) mRNA in skeletal muscle and assessment of serum omentin, adropin, irisin, and PGC-1α levels in high carbohydrate high fat (HCHF) diet induced obesity in rats. Sixty male albino rats are randomly divided into 4 groups (15 rats/group). In the first group (control), rats are fed with standard diet. The 2nd group (cont + swim) is fed on standard diet and made swimming exercise. The 3rd group of rats is fed on HCHF, whereas in the 4th group (HCHF + swim) is also fed on HCHF diet and made swimming exercise for 20 weeks. Blood glucose, insulin, HOMA-IR, lipid profile, omentin, irisin, adropin, and PGC-1α were measured. Also, FNDC5 and PGC-1α are extracted and purified from muscle tissue samples measured by PCR test.

Results
Our results showed significant increase in glucose, insulin, insulin resistance, cholesterol, and triglycerides with significant decrease in omentin, irisin, adropin, PGC-1α, and HDL in HCHF group as compared to the control group. These results improved after exercise in all parameter in HCHF + swim group compare to HCHF group. Also, there was inverse correlation between omentin and fasting glucose and HOMA-IR in HCHF + swim group.

Conclusions
It concluded that swimming exercise improved all the above measured parameters in serum and tissues which might have been promising for the prevention of metabolic diseases.
Socio-economic and demographic factors associated with adaptive behaviour among children diagnosed with autism spectrum disorder in Egypt
Authors: Ibrahim Nashwa , El-abdeen Asmaa Maher Zein , Ng Fiona , Zoromba Mohamed , Haikal Aml 
Published: September 2020

Abstract
Background
Adaptive behaviour among children diagnosed with autism spectrum disorder determines wide range of self-independent and autonomous activities. Adaptive behaviour is a clearly defined measurable variable that can be used as an outcome, hence impacts intervention and training programs. The current study aims to determine the socio-economic and demographic factors that are associated with adaptive behaviour among children diagnosed with autism spectrum disorder in Egypt. In this observational cross sectional study, caregivers’ reports on their children with a confirmed diagnosis of autism spectrum were obtained. Vineland Adaptive Behaviour Scale was used to assess adaptive behaviour among children aged 3–6 years and admitting at the outpatient clinic. Socioeconomic Status Scale was used to assess family socioeconomic status.

Results
Participants in the current study scored low in domains of adaptive behaviour. Older children scored low in adaptive behaviour compared to younger children. There was significant positive correlation between daily living activities subdomain of adaptive behaviour and education, occupation, family possessions, and home sanitation and health care domains of socioeconomic status scale. There were significant positive correlations between socialization subdomain of adaptive behaviour and education, occupation, family, and family possessions and home sanitation domains of the socioeconomic status scale. The motor functioning subdomain of adaptive behaviour correlates significantly with the following SES domains: education (r = .268), occupation (r = .274), family possessions (r = .232), economic (r = .195) and health care (r = .291). Results of the current study revealed that high socioeconomic status correlates with higher adaptive functioning in daily living skills, socialisation and motor skills domains of adaptive behaviour.

Conclusion
The correlations detected in the current study between adaptive behaviour and some social determinants of health can influence stakeholders’ decisions in planning and implementation of autism specific interventions.
Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma
Authors: Missaoui Nabiha , Bdioui Ahlem , Baccouche Atika , Belkacem Oussema , Hmida Wissem , Mokni Moncef , Hmissa Sihem 
Published: September 2020

Abstract
Background
The study investigated the expression and the clinicopathological significance of p53, p27, Ki-67, E-cadherin, and HER2 in upper urinary tract urothelial carcinomas (UTUC) from Tunisian patients. We performed a retrospective study of 66 UTUC. Main clinicopathological features were reported. The expression of p53, p27, Ki-67, E-cadherin, and HER2 was investigated by immunohistochemistry on whole tissue section.

Results
Expression of p53, Ki-67, p27, E-cadherin, and HERE2 was reported in 36.4%, 69.7%, 90.9%, 100%, and 0% of cases, respectively. p53 expression was associated with stage (p = 0.001), positive surgical margin (p = 0.005), and shorter recurrence-free survival (RFS; Log Rank test, p = 0.026). Ki-67 and p27 expression was associated with stage (p < 0.001 and p = 0.001, respectively) and grade (p < 0.001 and p = 0.001, respectively). Using Kaplan-Meier test, the positive surgical margin was associated with shorter RFS compared to free surgical margin (Log Rank test, p = 0.031). Moreover, in univariate Cox regression analysis, surgical margin (p = 0.041; HR 0.325, 95% CI 0.110–0.956) and p53 expression (p = 0.035; HR 0.328, 95% CI 0.116–0.925) were the significant factors associated with RFS.

Conclusions
Together, our findings suggest that positive surgical margin and p53 expression were potential prognostic factors of UTUC since both were associated with shorter RFS in Tunisian patients.
Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney
Authors: Brinkley Garrett , Nam Hyeyoung , Shim Eunhee , Kirkman Richard , Kundu Anirban , Karki Suman , Heidarian Yasaman , Tennessen Jason M. , Liu Juan , Locasale Jason W. , Guo Tao , Wei Shi , Gordetsky Jennifer , Johnson-Pais Teresa L. , Absher Devin , Rakheja Dinesh , Challa Anil K. , Sudarshan Sunil 
Published: September 2020

ABSTRACT
L-2-hydroxyglutarate (L-2HG) is an oncometabolite found elevated in renal tumors. However, this molecule might have physiological roles that extend beyond its association with cancer, as L-2HG levels are elevated in response to hypoxia and during Drosophila larval development. L-2HG is known to be metabolized by L-2HG dehydrogenase (L2HGDH), and loss of L2HGDH leads to elevated L-2HG levels. Despite L2HGDH being highly expressed in the kidney, its role in renal metabolism has not been explored. Here, we report our findings utilizing a novel CRISPR/Cas9 murine knockout model, with a specific focus on the role of L2HGDH in the kidney. Histologically, L2hgdh knockout kidneys have no demonstrable histologic abnormalities. However, GC-MS metabolomics demonstrates significantly reduced levels of the TCA cycle intermediate succinate in multiple tissues. Isotope labeling studies with [U-13C] glucose demonstrate that restoration of L2HGDH in renal cancer cells (which lowers L-2HG) leads to enhanced incorporation of label into TCA cycle intermediates. Subsequent biochemical studies demonstrate that L-2HG can inhibit the TCA cycle enzyme α-ketoglutarate dehydrogenase. Bioinformatic analysis of mRNA expression data from renal tumors demonstrates that L2HGDH is co-expressed with genes encoding TCA cycle enzymes as well as the gene encoding the transcription factor PGC-1α, which is known to regulate mitochondrial metabolism. Restoration of PGC-1α in renal tumor cells results in increased L2HGDH expression with a concomitant reduction in L-2HG levels. Collectively, our analyses provide new insight into the physiological role of L2HGDH as well as mechanisms that promote L-2HG accumulation in disease states.
An Axiomatic Foundation for the Expected Shortfall
Authors: Wang Ruodu , Zitikis Ričardas 
Published: September 2020

In the recent Basel Accords, the expected shortfall (ES) replaces the value-at-risk (VaR) as the standard risk measure for market risk in the banking sector, making it the most popular risk measure in financial regulation. Although ES is—in addition to many other nice properties—a coherent risk measure, it does not yet have an axiomatic foundation. In this paper, we put forward four intuitive economic axioms for portfolio risk assessment—monotonicity, law invariance, prudence, and no reward for concentration—that uniquely characterize the family of ES. Therefore, the results developed herein provide the first economic foundation for using ES as a globally dominating regulatory risk measure, currently employed in Basel III/IV. Key to the main results, several novel notions such as tail events and risk concentration naturally arise, and we explore them in detail. As a most important feature, ES rewards portfolio diversification and penalizes risk concentration in a special and intuitive way, not shared by any other risk measure. This paper was accepted by Manel Baucells, decision analysis.
How many medical beds does a country need? An international perspective
Authors: Jones Rodney P 
Published: September 2020

Background/Aims While many methods exist for calculating bed numbers, the current method for making international comparisons is inadequate, as it makes no adjustment for population age or the nearness to death effect. This study investigated the number of acute medical beds in various countries using a new method to compare bed numbers within and between countries. Methods The number of available medical beds in various (mainly European) countries were obtained from the World Health Organization. These were divided by the number of deaths in each country to give the ratio of beds per 1000 deaths and this was plotted against the ratio of deaths per 1000 population (the crude mortality rate) in each country. This was compared to similar data, but for occupied rather than available beds, for England over the period 2000/01 to 2018/19. Results In England, the medical group of specialties accounts for over 60% of all occupied acute beds. Since 2011 this proportion has risen to over 64%. For two decades England has had around 165±5 occupied medical beds per 1000 deaths (at an assumed 95% average occupancy), and England therefore has a similar number of medical beds to 11 of the 37 other countries. The relatively low slope of the relationship between beds per 1000 deaths and deaths per 1000 population indicates that the nearness to death effect is the major driving force for medical bed requirements. Conclusions Both data sets indicate that the nearness to death effect is the most important variable in forecasting occupied and available medical bed numbers. Based on the forecasted increase in deaths, demanf of medical beds in England is likely to increase by 39% over the next 40 years.
Use of a dual-layer amniotic membrane in the treatment of diabetic foot ulcers: an observational study
Authors: Sledge Isabella , Maislin David , Bernarducci Dave , Snyder Robert , Serena Thomas E 
Published: September 2020

Background: Despite advances in the treatment, fewer than half of diabetic foot ulcers (DFUs) heal in 12 weeks and 85% of non-traumatic amputations follow the development of a DFU. The search for treatment options continues. Placental-derived products have shown promise in the treatment of DFUs. This study investigates Artacent (Tides Medical, US), a unique amniotic patch containing two layers of amnion and its potential to increase growth factor delivery. Method: This observational analysis included patients with DFUs with documented failure to heal by >50% after the protocol-defined run-in period (either two or four weeks) of standard of care (SOC), and who had been randomised in a larger clinical trial that had been discontinued earlier for logistical reasons. Patients were randomised to either weekly or biweekly application of the dual-layer amniotic membrane (DLAM) plus SOC and were included in per-protocol effectiveness analyses. Descriptive statistics were chosen for this analysis. Primary endpoint was complete closure at 12 weeks. Results: A total of 26 patients were included in the analysis. Examination of baseline patient characteristics revealed that the ulcers were larger than in most DFU clinical trials (4.65±4.89cm2). For the primary endpoint, 17/26 (65%, 95% CI: 44–83%) of the combined treatment arms achieved complete closure. The small sample size precluded a meaningful comparison of healing between weekly and biweekly DLAM applications. Conclusion: The observations taken from the discontinued clinical trial suggest that the DLAM promotes healing of DFUs. The healing rates are similar to those in other placental-based tissue studies. In addition, the relatively larger size of the ulcers suggests that the DLAM may be effective in ulcers that are more resistant to standard of care. In the future, a revised clinical trial with a greater sample size is planned.
Is the end nigh?
Authors: Jacobs D 
Published: September 2020

A year after its launch, the results of the Department of Health & Social Care’s (DHSC) consultation on ‘appropriate clinical negligence cover’ are still widely anticipated. In this article, we explore the benefits and disadvantages of regulated and discretionary indemnity cover as understood by the DHSC, the medical defence organisations (MDOs), insurance brokers and underwriters. We also turn to surgeons and clinicians with private practices to ask what they think about the current arrangements. Reforms to medical indemnity insurance forecast the passing of the UK's long-established medical defence and protection organisations.