bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between triglyceride glucose-body mass index and risk factors linked to non-alcoholic liver disease in subjects with metabolic syndrome
Authors: Bullón-Vela Vanessa , Abete Itziar , Angeles Zulet M. , Alfredo Martínez J. 
Published: June 2020

AbstractIntroductionNon-alcoholic fatty liver disease (NAFLD) is a chronic liver condition, whose prevalence increases in parallel with obesity, diabetes and metabolic syndrome (MetS) rates. The aim of the study was to investigate the relationships between the triglyceride glucose-body mass index (TyG-BMI) with lifestyle, dietary variables, and metabolic risk factors linked to NAFLD in subjects diagnosed with MetS.Materials and methodsA baseline cross-sectional study on 331 participants (aged 65.8 ± 5.1 years) recruited in Navarra was conducted. Subjects were stratified by tertiles of the TyG-BMI index. Dietetic, Mediterranean diet adherence (MedDiet-17 points) and physical activity data were assessed through validated questionnaires. Sociodemographic, lifestyle, anthropometric and biochemical parameters were also recoreded. The Cockcroft-Gault equation was performed to estimate clearance of creatinine. For comparisons between TyG-BMI tertiles and several variables, ANCOVA and chi-square test analyses were performed.ResultsSubjects in T3 of TyG-BMI index were more likely to have diabetes (50.9%). Interestingly, physical activity decreases across tertiles (p = 0.030). There were no differences between tertiles in energy intake and MedDiet adherence. However, total meat consumption is highest in T3. ANCOVA test after adjustment for potential confounders revealed that participants in T3 showed more several clinical and metabolic alterations. Moreover, ALT (p = 0.002) and GGT (p = 0.047) levels increased and mean corpuscular volume decreased across tertiles of the TyG-BMI index.DiscussionObesity, MetS and insulin resistance (IR) play a key role in the development of NAFLD promoting lipotoxicity and overproduction of proinflammatory mediators. This state induces hepatic steatosis and liver injury. Some studies suggest TyG-BMI index as a surrogate marker of IR and risk to NAFLD(1). In our study, patients in the highest TyG-BMI tertile showed more adverse cardio-metabolic profile, lower physical activity and higher total meat intake. In summary, the TyG-BMI index could be a simple and reliable marker to characterize the risk of NAFLD among individuals diagnosed with MetS.
Role of circulating S100A4 protein in obesity: a case-control study in prepuberal children
Authors: Méndez-Gutierrez Andrea , Anguita-Ruiz Augusto , Ruperez Azahara I. , Leis Rosaura , Bueno Gloria , Gil-Campos Mercedes , GIL ANGEL. , Aguilera Concepción M. 
Published: June 2020

AbstractIntroduction:Childhood obesity is considered one of the most serious public health problems of the 21st century. Obesity-associated inflammation could be one of the mechanisms that triggers insulin resistance that could drive systemic alterations such as metabolic disorder. Recently, circulating levels of S100A4 has been associated with insulin resistance and subcutaneuous white adipose tissue inflammation independently of body mass index (BMI) in a cohort of obese adults. Nonetheless, the link between S100A4 and insulin resistance in children is still not known yet. Thus, the aim of the study was to determine if S100A4 plasma levels were associated with insulin resistance status in a cohort of prepuberal children.Material and methods:In this case-control multicentre study, 250 prepuberal children took part and were stratified in six groups according to sex, obesity stage and insulin resistance status. Blood samples were withdrawn in resting conditions after an overnight fasting. Anthropometric measurements and a routine biochemical analyses were performed. Homeostasis model assessment for insulin resistance index (HOMA-IR) was calculated using fasting plasma glucose and insulin values. S100A4 plasma levels were determined by ELISA CSBEL02032HU (Cusabio Biotech, Wuhan, China).Results:A lineal multiple regresión (α = 0.05) identified a significative association between S100A4 plasma levels and HOMA-IR in the cohort; each HOMA-IR increasing unit correlated with an increase of 0.008mg/dL in S100A4 plasma levels. (SE = 0.003 and p = 0.02). Moreover, we also observed a positive significative association between S100A4 plasma levels and glucose blood levels (p = 0.005) and BMI (p = 0.008). Inter-group comparations analyses revealed significative differences between normal-weight and insulino-resistant obese boys (p = 0.024). The same result was obtained between normal-weight and insulino-resistant obese girls (p = 0.04), finding a higher S100A4 concentration in insulino- resistant children. As expected, plasma S100A4 levels were also higher in obese children versus normal-weight children (p = 0.02).Discussion:These data could be clinical relevant due to the possible potential of S100A4 protein as a new circulating biomarker of resistance insulin in a cohort of prepuberal children. These results are supported by other studies in obese adults and adolescents. In conclusion, these results suggest that S100A4 is associated with obesity and insulin resistance in prepuberal children. However, more studies are needed to study the implication and mechanism of this protein in the development of insulin resistance.
A pilot study of low-carbohydrate diet intervention on overweight or obese elderly people in China
Authors: Ye Yan-Bin , HO HOI YAN. , Zhuo Shu-Yu 
Published: June 2020

AbstractIntroduction:Muscle-reducing obesity is the most common form of obesity in the elderly, so it is more difficult for the elderly to lose weight. The efficacy and safety of low-carbohydrate diet (LCD) for weight loss in the elderly remains controversial. This study aimed to explore the effect and safety of LCD on weight loss in overweight and obese elderly people.Materials and Methods:Obese or overweight elderly (> 60 years old) with a BMI greater than 24 were recruited to use a restricted LCD for 1–3 months for weight loss intervention. According to the time, participants were divided into short-time group (< 30 days), medium-time group (< 31–60 days) and long-time group (> 60 days). The enrolled subjects were given an energy-restricted LCD for weight reduction intervention (1200–1400 kcal/d, carbohydrate accounts for 15–20% of energy). The primary outcome was change in body composition included weight, BMI, fat mass, and waist circumference, and there were other secondary outcomes including blood sugar, blood lipid and uric acid.Results and Discussion:Thirty-two obese or overweight elderly completed a LCD for 1–3 months, mean age were 64.9 ± 4.2 years, median intervention time was 56 (range: 26,100); mean BMI was 29.62 ± 3.70kg/m2. After LCD intervention, the average body weight of the three groups decreased by 2.92 ± 0.77 kg, 5.57 ± 1.99 kg and 10.48 ± 2.63 kg; the average BMI decreased by 1.43 ± 0.34 kg/m, 2.18 ± 0.99 kg/m and 3.18 ± 1.77 kg/m; the average body fat decreased by 2.28 ± 0.43 kg, 4.07 ± 2.08 kg and 7.05 ± 2.53 kg; and the average muscle decreased by 0.68 ± 0.76 kg, 1.32 ± 0.78 kg and 2.45 ± 2.03 kg (P < 0.05). The average muscle loss was less than 20% of the total weight loss. Covariance analysis adjusted by sex and age showed that the percentage changes of body weight, BMI, body fat and waist circumference were significant different among the three groups (p < 0.05), which had linear trends with the intervention time, while the percentage of muscle and body fat decreased was not significantly different among the three groups, and did not increase with the intervening time (p > 0.05). Symptoms of patients with hypertension or sleep apnea syndrome were alleviated. There were no serious adverse events during weight loss.LCD with restricted energy is a safe and effective weight-loss intervention for overweight or obese elderly people. It can significantly reduce BMI and body fat without losing more muscle with the increase of weight loss time.
Real ileal digestibility of sunflower protein and amino acids in humans
Authors: Tessier Romain , Calvez Juliane , Khodorova Nadezda , Quinsac Alain , Kapel Romain , Tomé Daniel , Airinei Gheorghe , Benamouzig Robert , Gaudichon Claire 
Published: June 2020

AbstractIntroduction:Sunflower protein is not used in human nutrition despite a relatively good amino acid composition. However, the bioavailability of sunflower isolate has never been measured in Humans. The goal of this work was to determine ileal digestibility of protein and amino acids from a sunflower isolate in healthy volunteers and to challenge newly developed dual isotope method.Materials and methods:Eight healthy volunteers were equipped with a naso-ileal tube. They received during four hours twelve doses of biscuits containing, in total, 25 g of 15N sunflower protein isolate together with 400 mg of a mixture of free 13C amino acids incorporated in chocolates. Polyethylene glycol was perfused as non-absorbable marker and ileal contents were collected during 8 hours after ingestion of the first meal. Real ileal digestibility was measured by assessing nitrogen and carbon content as well as 15N and 13C enrichments by EA-IRMS. Amino acid digestibility was determined by measuring 15N and 13C enrichments by GC-C-IRMS and quantity of amino acids by UPLC. Blood was collected for 8 h to determine 15N and 13C enrichments by GC-C-IRMS.Results:The ileal nitrogen flow was 2.7 ± 0.5 mL/min (mean ± SD). In average, 53.1 ± 12.0 mmol of exogenous nitrogen was recovered during the eight hours of experiment, resulting in an ileal digestibility of sunflower isolate was 85.6 ± 2.6 % of nitrogen ingested. 13C amino acids were also recovered at the ileal level. The mixture of free 13C revealed an ileal digestibility of 94.9 ± 0.9 %. Ileal indispensable amino acids digestibility and DIAAS are in progress.Discussion:Ileal digestibility of sunflower isolate incorporated in toasted biscuits was lower than the value found or a raw isolate in a rat model (94.5%). The study revealed that 5 % of free amino acids were not absorbed in the ileum. Amino acid digestibility will complete the study to evaluate the DIAAS of sunflower isolate and to compare values obtained with the standard method and with the dual isotope method.
Decreased hippocampal efficiency in obese rats is expressed by impaired cognition, neurogenesis and proteomic changes
Authors: Liśkiewicz Arkadiusz , Marczak Łukasz , Przybyła Marta , Sługocka Anna , Liśkiewicz Daniela , Nowacka-Chmielewska Marta , Student Sebastian , Bogus Katarzyna , Małecki Andrzej , Lewin-Kowalik Joanna 
Published: June 2020

AbstractObesity associates with plethora of dysfunctions including changes in the brain structures, like hippocampus which is particularly susceptible to metabolic or inflammatory alterations. The is a need to expand knowledge about the obesity related brain changes in order to enable development of new therapeutic interventions, that would support not only weight loss but also could help to restore the after-effects of obesity in the brain. In the present report we evaluated the hippocampal efficiency of obese rats. In order to induce obesity 4 weeks old male rats were fed with a chow that mimics human western diet for 12 weeks (model of diet induced obesity). Then the cognitive functions (water maze), neurogenesis (BrdU detection) and global proteomic changes (MS/MS analysis) were analyzed in separate cohorts of animals. Obese rats had worsen cognitive flexibility than normal rats, but the spatial learning and long term memory were unaffected. The number of BrdU/NeuN positive cells was lowered in obese animals suggesting decreased hippocampal neurogenesis. The analysis of proteins revealed that about 120 proteins significantly differed between hippocampi of obese and normal rats. Neuronal calcium sensor 1 (NCS-1) which participates in mechanisms involving synaptic plasticity and acquisition of spatial memory was decreased in obese rats. Neuromodulin and vinculin, required for synaptic plasticity also decreased in these animals. Impaired neurogenesis was associated with decreased level of: receptor-type tyrosine-protein phosphatase zeta and cytoplasmic dynein 1 light intermediate chain 2, which play crucial roles in controlling axonal growth and neuronal migration. Altogether the data show that proteomic changes related to obesity associate with impaired hippocampal functioning. The same set of experiments was performed on the additional cohort of obese animals subsequent to weight loss to examine if the observed brain changes persist if obesity is reversed. This research is supported by Nutricia Foundation, grant no. RG 1/2017.
Age period cohort analysis in cancers associated with overweight and obesity in Ireland
Authors: O'Neill Colette , Donnelly Conan 
Published: June 2020

AbstractThe Central Statistics Office (CSO) in Ireland report that 62% of adults were overweight or obese in 2017(1). In 2019, the latest data from the national longitudinal study “Growing Up in Ireland” showed that 15% of five-year olds were overweight and 5% were obese(2). According to WHO projections, Ireland may have the highest prevalence of overweight and obesity in Europe by 2030(3). The International Agency for Research on Cancer (IARC) state there is sufficient evidence for a cancer preventative effect of the absence of excess body fatness for 13 different cancer sites(4). Recent USA based research showed that the risk of developing an obesity-related cancer seems to be increasing in a stepwise manner in successively younger birth cohorts(5), therefore we aimed to investigate trends in the age of obesity related cancer diagnosis.National Cancer Registry Ireland (NCRI) data was obtained for 25 to 84 year olds between 1997 and 2016 for several cancer types and 5-year intervals were constructed to categorise age (25–29, 30–34 etc.) and year of diagnosis (1997–2001, 2002–2006 etc.). An age-period-cohort model was fitted to each cancer type, resulting in estimated temporal trends in incidence (expressed as annual percent change (APC) per year) and significance of the trend across age groups was tested using a Wald test(5).Analysis of NCRI data reflect significantly increasing incidence of colorectal cancer with decreasing age in Ireland (n = 40703, p = 0.00). Despite the limitation of low numbers for several cancer sites in younger age groups, similar trends were observed for a number of cancer types including thyroid and cervical cancer (p < 0.05). Although other factors (such as early detection) may contribute to these observations, addressing the large increase in incidence of obesity and colorectal cancer among young adults is essential. Research to identify exposure to modifiable risk factors, including nutrition and physical activity, throughout life in Ireland is necessary to examine potential determinants of such trends.
Is Histidine promising in alleviating the risk of Metabolic disorder?
Authors: Okekunle Akinkunmi Paul , Adeboye Temitope Elizabeth , Feng Rennan 
Published: June 2020

AbstractIntroductionIn recent times, evidence from published reports; randomized clinical trial (RCT), human case-controls, metabolomics, animal and cell studies is gaining rapt significance on the ameliorative potential of histidine (His) in obesity/insulin resistance (IR)/ inflammation outcomes. This study aimed at systematically mining evidence from previously published studies on the vitality of His on metabolic disorder outcomes.MethodsUsing the MOOSE guidelines we searched PubMed and Cochrane library using the search words “histidine” and “obesity” or “diabetes” or “metabolic syndrome” and included articles on His intake/administration and obesity/diabetes/metabolic disorders involving human and/or animal experimentation.ResultsWe found low circulating His profile has been associated with metabolic disorders independent of ethnicity [1–4]. Similarly, two separate animal trials [5–6] found His to be significantly lower in diabetic Balb/cA mice and lean Zucker rat. Also, the endogenous absence of His disrupts mitochondrial membrane integrity thereby impairing energy production [7]. In addition, epidemiological report revealed higher dietary His was associated with lower overweight and obesity risk [8]. Though epidemiological reports from the diverse population to assert this observation are insufficient, reports from animal models [9–10] revealed similar conclusions. Also, some reports [11–12] have demonstrated the dose-dependent inhibitory effect of His on some inflammatory markers by assuaging the palmitic acid induced pAkt/Akt expression [12]. Also, His inhibits the up-production of free radicals to impede the extracellular signal-regulated kinase in neurons [13].ConclusionThese evidences are novel but primarily limited to mostly obesity. In our opinion, future multi-ethnic longitudinal cohort and trials should consider exploring effects of His on non-fatty alcoholic liver diseases and cardiovascular complications. His might as well be beneficial potentially offering significant hope and non-invasive alternatives in the management of metabolic disorders.Note:Complete citations available inMEDLINE;[1] PMID: 20834187 [2] PMID: 22266733 [3] PMID: 21996294 [4] PMID: 23697717 [5] PMID:15878720 [6] PMID:15389298 [7] PMID: 4621606 [8] PMID: 27409634 [9] PMID: 17372311 [10] PMID: 15561489 [11] PMID: 16107255 [12] PMID: 23361591 [13] PMID: 22101981
Consumption of maize food group and its contribution on the diet of rural women in México
Authors: Benítez-Arciniega Alejandra Donaji , Vizcarra-Bordi Ivonne , Ochoa-Rivera Teresa , del Carmen Guzmán-Márquez María , Morales-González Lizbeth , Hernández-Ramírez Jaqueline 
Published: June 2020

AbstractNative maize is the main cereal in the diet in rural communities in México, especially in those with a traditional maize-based food-pattern. Although maize has a high nutritional value, its consumption in rural communities has declined in recent decades. Traditional food replacement by modern and processed foods seems to adversely affect the composition of the diet. The aims of this study were: to evaluate the consumption of maize, its influence on nutrient intake in Matlatzincas women, and to analyze the association between the intake of maize food products with specific nutrients within the context of the most current dietary pattern in this indigenous group from central México. In this longitudinal study, we assessed diet over a one-year period, using eight 24-h dietary recalls and a food frequency questionnaire in a rural representative sample of 92 indigenous women aged 19 to 90 years. We derived dietary patterns using principal component analysis based on the intake of ten predefined food groups according to the Mexican equivalents food system. A specific food group based on maize products (maize-food-group) such as tortilla, sopes, pozole, atole, pinole, tacos, etc., was created to identify separately maize consumption in the habitual diet. The percentage of daily energy intake attributed to maize-food-group as well as the intake of macro and micronutrients were estimated. Based on the nutrimental composition of each food group, we analyzed habitual intakes of energy (kcal/d), carbohydrates, proteins, lipids, fiber, vitamins A, D, C and B12 (mg/d), and micronutrients: phosphorus, calcium, iron and zinc (mg/d). Analysis of variance and Pearsońs correlation test were used to evaluate the association between the tertiles of the consumption of maize-food-group and nutrient intake. Additionally, a diet score was calculated to assess diet quality according to maize-food-group consumption. All dietary data were energy-adjusted for the analysis. The consumption of maize-based-foods corresponded to 23.0% of the total caloric intake. Consumption of maize was higher among older women. Consumption of maize-food-group was positively correlated with the ingest of proteins, lipids, dietary fiber, calcium, phosphorus, iron, B12 vitamin, D vitamin and energy (p < 0.05). Better diet quality was associated with a high consumption of maize-food-group. We conclude that the high consumption of maize food products and its positive correlation with the intake of recommended nutrients for healthy diet in adult women, needs interventions in public health to promote a better diet-quality aimed to increase the intake of maize-based food group.
Development of a dedicated repertoire and food frequency questionnaire for estimating dietary fiber intake taking into account prebiotic (oligo)saccharides
Authors: Neyrinck Audrey M. , Nazare Julie-Anne , Sothier Monique , Vandenberghe Laurie , Amadieu Camille , Rodriguez Julie , Alligier Maud , Laville Martine , Delzenne Nathalie M. 
Published: June 2020

AbstractRationaleThe scientific rationale for the recommendation in dietary fiber (DF) intake comes from the recognition of their health benefits. European Food Safety Authority (EFSA) recommend 25 g/d, based on the amount needed for intestinal laxation. Gut microbiota related health benefits are not yet included in the current dietary recommendations. Appropriate (and consensual) quantitative and qualitative analysis of DF are missing in food composition tables. One of the aim of the FiberTAG(1) project was to develop a dedicated database and a food frequency questionnaire (FFQ) allowing DF intake estimation including prebiotic (oligo)saccharides.MethodsA repertoire of DF detailing total, soluble and insoluble DF in food products consumed in Europe has been established based on the Souci-Fachmann-Kraut database, completed for soluble versus insoluble DF () and for prebiotic (oligo)saccharide levels using published data. The FiberTAG FFQ was submitted to healthy volunteers (7 men, 8 women; mean age: 21 yrs; mean BMI: 22kg/m2) and DF intakes were calculated using the new FiberTAG repertoire.ResultsThe FiberTAG repertoire detailed DF in 400 food items allocated into 4 categories (fruits, vegetables, cereal products and others) and 15 subcategories. The fiberTAG FFQ consists in 280 items regrouped in 4 high DF-containing food groups (vegetables including legumes, fruits including nuts and seed, cereal products and others) using frequency scale (6 categories), photographs for portion size and taking into account the seasonal occurrence for some vegetables or fruits. Data obtained from FiberTAG FFQ indicate a total DF intake of 36.44 g/d. This reveals a higher DF intake compared to previously reported intake for adults in Europe ranging from 16 to 24 g/d based on 24 h-recall or 3–7 days records(2). This difference might be explained by a more adequate inclusion of fruits and vegetables intake in FFQ than with other methods, as previously reported(3). Our data also showed that fructan, inulin and fructo-oligosaccharides intakes were 4.18, 2.95 and 1.00 g/day, respectively whereas galacto-oligosaccharides intake was 0.28 g/d.ConclusionThe new FiberTAG DF repertoire and FFQ are tools to evaluate the total amount of DF including prebiotic (oligo)saccharides ingested by healthy volunteers. The FiberTAG project generates scientific knowledge that helps to take into account microbiota-nutrient interactions to establish DF intake recommendations as part of healthy lifestyles.