bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report: a rapid review approach used by the UK National Screening Committee to inform recommendations on general population screening for vasa praevia
Authors: Leonard Saoirse , Buchanan-Hughes Amy , Bobrowska Anna , Visintin Cristina , Marshall John 
Published: December 2019

Abstract
Background
The UK National Screening Committee (UK NSC) reviews evidence about existing or potential population screening programmes using rapid review products called evidence summaries. We provide a case report as an example of how rapid reviews are developed within the UK NSC’s process, consider how the quality of rapid reviews should be assessed and ask whether the rapid review was an appropriate tool to inform the UK NSC’s decision-making process.

Methods
We present the rapid review approach taken by the commissioner and the reviewers to develop an evidence summary for vasa praevia (VP), which the UK NSC reappraised as part of its 3-yearly cycle for conditions where screening is currently not recommended. We apply the AMSTAR 2 quality appraisal checklist for systematic reviews, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist and a published checklist of items to consider with a rapid review approach. As UK NSC evidence summaries do not include meta-analyses, any related AMSTAR 2 or PRISMA checklist items were considered inapplicable.

Results
The evidence summary was available within the required timelines and highlighted little change from the previous review in terms of key evidence gaps relating to the epidemiology of VP, the screening test and the management pathway. Therefore, the UK NSC concluded that there was insufficient evidence to support a change in its previous recommendation against screening. The evidence summary scored moderately against the applicable AMSTAR 2 and PRISMA checklist items. Against the published checklist of items to consider with a rapid review approach, the evidence summary performed well.

Conclusions
In this case report, the use of a rapid review as part of the UK NSC’s process enabled a pragmatic approach to assessing the overall volume, quality and direction of literature on key questions relating to the viability of a population screening programme for VP. Based on our assessments of this single evidence summary, systematic review quality appraisal tools may undervalue rapid reviews. The validity of the methods used in this case report, as well as the wider generalisability of our insights relating to rapid review practice, reporting and quality assessment, requires analysis of a larger sample of rapid reviews.
Inhibitory Interplay of SULT2B1b Sulfotransferase with AKR1C3 Aldo-keto Reductase in Prostate Cancer
Authors: Park Sulgi , Song Chung-Seog , Lin Chun-Lin , Jiang Shoulei , Osmulski Pawel A , Wang Chiou-Miin , Marck Brett T , Matsumoto Alvin M , Morrissey Colm , Gaczynska Maria E , Chen Yidong , Mostaghel Elahe A , Chatterjee Bandana 
Published: January 2020

Abstract
SULT2B1b (SULT2B) is a prostate-expressed hydroxysteroid sulfotransferase, which may regulate intracrine androgen homeostasis by mediating 3β-sulfation of dehydroepiandrosterone (DHEA), the precursor for 5α-dihydrotestosterone (DHT) biosynthesis. The aldo-keto reductase (AKR)1C3 regulates androgen receptor (AR) activity in castration-resistant prostate cancer (CRPC) by promoting tumor tissue androgen biosynthesis from adrenal DHEA and also by functioning as an AR-selective coactivator. Herein we report that SULT2B-depleted CRPC cells, arising from stable RNA interference or gene knockout (KO), are markedly upregulated for AKR1C3, activated for ERK1/2 survival signal, and induced for epithelial-to-mesenchymal (EMT)-like changes. EMT was evident from increased mesenchymal proteins and elevated EMT-inducing transcription factors SNAI1 and TWIST1 in immunoblot and single-cell mass cytometry analyses. SULT2B KO cells showed greater motility and invasion in vitro; growth escalation in xenograft study; and enhanced metastatic potential predicted on the basis of decreased cell stiffness and adhesion revealed from atomic force microscopy analysis. While AR and androgen levels were unchanged, AR activity was elevated, since PSA and FKBP5 mRNA induction by DHT-activated AR was several-fold higher in SULT2B-silenced cells. AKR1C3 silencing prevented ERK1/2 activation and SNAI1 induction in SULT2B-depleted cells. SULT2B was undetectable in nearly all CRPC metastases from 50 autopsy cases. Primary tumors showed variable and Gleason score (GS)-independent SULT2B levels. CRPC metastases lacking SULT2B expressed AKR1C3. Since AKR1C3 is frequently elevated in advanced prostate cancer, the inhibitory influence of SULT2B on AKR1C3 upregulation, ERK1/2 activation, EMT-like induction, and on cell motility and invasiveness may be clinically significant. Pathways regulating the inhibitory SULT2B-AKR1C3 axis may inform new avenue(s) for targeting SULT2B-deficient prostate cancer.
Feasibility Study of a Novel Protease-Activated Fluorescent Imaging System for Real-Time, Intraoperative Detection of Residual Breast Cancer in Breast Conserving Surgery
Authors: Smith Barbara L. , Lanahan Conor R. , Specht Michelle C. , Kelly Bridget N. , Brown Carson , Strasfeld David B. , Ferrer Jorge M. , Rai Upahvan , Tang Rong , Rice-Stitt Travis , Biernacka Anna , Brachtel Elena F. , Gadd Michele A. 
Published: January 2020

Abstract
Background
Obtaining tumor-free margins is critical to prevent recurrence after lumpectomy for breast cancer. Unfortunately, current approaches leave positive margins that require second surgeries in 20–40% of patients. We assessed the LUM Imaging System for real-time, intraoperative detection of residual tumor.

Methods
Breast lumpectomy cavity walls and excised specimens were assessed with the LUM Imaging System after 1 mg/kg intravenous LUM015, a protease-activatable fluorescent agent. Fluorescence at potential sites of residual tumor in lumpectomy cavity walls was evaluated intraoperatively with a sterile hand-held probe, with real-time predictive results displayed on a monitor intraoperatively, and later correlated with histopathology.

Results
In vivo lumpectomy cavities and excised specimens were imaged after LUM015 injection in 45 women undergoing breast cancer surgery. Invasive ductal and lobular cancers and intraductal cancer (DCIS) were included. A total of 570 cavity margin surfaces in 40 patients were used for algorithm development. Image analysis and display took approximately 1 s per 2.6-cm-diameter circular margin surface. All breast cancer subtypes could be distinguished from adjacent normal tissue. For all imaged cavity surfaces, sensitivity for tumor detection was 84%. Among 8 patients with positive margins after standard surgery, sensitivity for residual tumor detection was 100%; 2 of 8 were spared second surgeries because additional tissue was excised at sites of LUM015 signal. Specificity was 73%, with some benign tissues showing elevated fluorescent signal.

Conclusions
The LUM015 agent and LUM Imaging System allow rapid identification of residual tumor in the lumpectomy cavity of breast cancer patients and may reduce rates of positive margins.
'Known and Feeling Sorrows': Disabled Knowledge and King Lear
Authors: Row-Heyveld Lindsey 
Published: December 2019

This essay argues that King Lear presents a version of disability determined not by bodily authenticity but by bodily knowledge. By staging multiple forms and experiences of disability, the play defies the drive to authenticate and control non-standard bodies that flourished in early modern England. King Lear’s insistence on embodied knowledge both recognizes the unique perspective afforded to disability and resists disability exceptionalism through its attention to populations made vulnerable to impairment. King Lear specifically dramatizes the way disabled knowledge extended to precarious populations by granting Edgar disabled knowledge even though his disability is fraudulent.
What is Commedia dell’Arte Today? A Review Essay
Authors: Drabek Pavel 
Published: December 2019

This essay reviews seven recent volumes on the commedia dell'arte: Christopher B. Balme, Piermario Vescovo, and Daniele Vianello's edited volume Commedia dell’Arte in Context (2018); Judith Chaffee and Oliver Crick's edited The Routledge Companion to Commedia dell’Arte (2014); Erith Jaffe-Berg's Commedia dell’ Arte and the Mediterranean: Charting Journeys and Mapping ‘Others’ (2016); Andrea Fabiano's La Comédie-Italienne de Paris et Carlo Goldoni: De la commedia dell’arte à l’opéra-comique, une dramaturgie de l'hybridation au XVIIIe siècle (2018); Emily Wilbourne's Seventeenth-Century Opera and the Sound of the Commedia dell’Arte (2016); Natalie Crohn Schmitt's Befriending the Commedia dell’arte of Flaminio Scala: The Comic Scenarios (2014); and Markus Kupferblum's Die geburt der neugier aus dem geist der revolution. Die commedia dell’arte als politisches volkstheater (2013).
Online Algorithms for Multilevel Aggregation
Authors: Bienkowski Marcin , Böhm Martin , Byrka Jaroslaw , Chrobak Marek , Dürr Christoph , Folwarczný Lukáš , Jeż Łukasz , Sgall Jiří , Thang Nguyen Kim , Veselý Pavel 
Published: January 2020

Online Algorithms for Hierarchical Aggregation Problems Data and inventory aggregation problems arise in multicasting, sensor networks, communication in organization hierarchies, and in supply chain management. These problems are naturally online, in the sense that aggregation decisions need to be made without information about future requests. We study these problems with a general tree structure of links that can be used for deliveries. This generalizes some well-studied optimization problems: trees of depth one capture the TCP acknowledgment problem, and trees of depth two capture the joint replenishment problem. For trees of depth one and two, constant-competitive online algorithms are known. We solve a major open problem by giving a constant-competitive algorithm for trees of arbitrary (fixed) depth. The algorithm works for arbitrary waiting cost functions, including the variant with deadlines.
Sistema de Informação do Programa Nacional de Suplementação de Ferro (PNSF)
Authors: Coelho Thereza Christina Bahia , Almeida Samila Nathalia Bispo de 
Published: December 2019

Objetivo: realizar uma análise descritiva e crítica sobre o desempenho deste sistema. Método: desenho do tipo retrospectivo com a utilização de dados primários (entrevistas com profissionais de saúde, gestores e usuários do programa), e secundários (dados do SI do PNSF e relatórios da Coordenação Geral de Alimentação e Nutrição, da gestão estadual e municipal, dentre outros documentos). Na análise da qualidade e pertinência da informação foram utilizadas as categorias: completude, confiabilidade, atualidade, acesso, fidedignidade, correção das metas, e coerência da informação com as metas e políticas vigentes. Resultados: apesar do SI dispor de dados de fácil acesso, os resultados apontaram erros no estabelecimento das metas e coberturas do programa e alimentação dos dados. A acessibilidade também foi prejudicada impedindo a utilização dos dados para tomada de decisão tanto no nível local, intermediário e nacional. Ademais, sérios problemas de planejamento decorrentes, pelo menos em parte, da cultura institucional que alicerça as práticas de saúde e mantém a informação como segredo ou recurso de poder político e burocrático, foram encontrados. Conclusão: Estudos e intervenções no sentido do aclaramento e resolução destas questões poderão contribuir para o aprimoramento dos sistemas de informação em saúde, de maneira a permitir o controle e redução da anemia por deficiência de ferro. AbstractObjectives: This article aimed to perform a descriptive and critique analysis of this system performance using as research outline the generation and use of data at the municipal level. Methods: The retrospective design used interviews with health professionals, managers and users of the program as the primary data, and, SI PNSF data and reports from the General Commission of Food and Nutrition, the state and municipal management, among other documents as a secondary material. The quality and relevance of the information was analyzed through the categories: completeness, reliability, timeliness, access, correction of goals and consistency of the information with the goals of health politics. Results: Despite the SI have easily accessible data, the results showed errors in setting national goals and program coverage, in addition to wrong data input by local coordinators. Accessibility was also affected, disallowing the use of data for decision making at the local, intermediate and national levels. Finally, there were serious planning problems arising, at least in part, the institutional culture that underpins health practices and maintains the information as secret or as political and bureaucratic power resource. Conclusion: Studies and interventions towards the clearing and settlement of these issues could contribute to the improvement of health information systems, and in particular the PNSF, so as to allow the control and reduction of iron deficiency anemia in children and pregnant Brazilian women.
Understanding the educational value of the film Please Vote for Me: The case for a pedagogical course in citizenship education
Authors: Wong Mei-Yee 
Published: December 2019

Abstract
Studies have demonstrated the importance of citizenship education for preservice teachers; however, studies on citizenship education pedagogies in university programmes have been rare. This small-scale study furthers the discussions in western and Chinese literature regarding the documentary film Please Vote for Me. By using the film in a citizenship and moral education curriculum course, this study explored undergraduate students' perceptions of using the documentary film Please Vote for Me and their actual learning experiences and outcomes. Data were collected through student interviews, reflective journals and worksheets. The study revealed that, overall, the students appreciated learning by using documentary films; they learned reflection and critical thinking skills and about the concept of democracy. They also discussed the educational topics in the film and reflected on the expected teacher and parent roles of citizenship education. The study provides empirical evidence to supplement the literature on citizenship teaching and learning in teacher education by using a documentary film as a resource.
Civic perspective-taking: Examining how young children engage with locally relevant public issues
Authors: Toledo William 
Published: December 2019

Abstract
This manuscript examines the civic perspective-taking of second-grade students in three majority non-white classrooms as they participated in a civics unit with a perspective-taking focus. Specifically, this work examines student learning related to key concepts within the unit through analyses of individual student work samples and small group work and discussions. Based on these data, a rubric of learning civic perspective-taking and related concepts is presented. Patterns in student work are examined through three student exemplars that demonstrate advanced, developed and limited levels of understanding of key concepts throughout the unit. Larger patterns of student understandings from these three classrooms are also discussed.
Learning to live together in polarized and pluralistic societies: Hong Kong teachers' views of democratic values versus patriotic values
Authors: Wong Koon Lin , Lee Chi Kin John 
Published: December 2019

Abstract
Under 'One Country, Two Systems', 'good citizens' – as supported by pro-democratic positions – and 'good citizens' – as promoted by the Chinese government – are seemingly in contradiction with each another based on their values and ideologies in Hong Kong. The competing values of citizenship are demonstrated by deep divisions within Hong Kong society, with pro-democratic groups advocating democratic values and initiating societal transformation, and their pro-establishment counterparts highlighting patriotic values and sustaining the status quo. From an educational perspective, teachers take on an essential role in the implementation of education policies designed to cultivate students who are 'good citizens'. This research employed a mixed-methods approach to examine Hong Kong teachers' perceptions of 'good citizens' based on their affinity with democratic and patriotic values. The findings indicated that rather than conflicting, patriotic values tended to be complementary to democratic values. Moreover, critical patriotic citizens with multiple identities who participate rationally and constructively in social and political activities might be more likely to facilitate democratic development in Hong Kong. These findings have implications for policy-makers responsible for the citizenship education and preparation of future citizens living within polarized and pluralistic societies, and they highlight the value of learning to live together in a complex world.
Controversies are no excuse: Citizenship education in Spain
Authors: Buxarrais Maria Rosa , Ortega Eric 
Published: December 2019

Abstract
Here we discuss the current situation of citizenship education in Spain, briefly reviewing its legal and political context, and taking into account a questionnaire administered to an intentional sample of key informants. We argue that even though the compulsory subject 'education for citizenship and human rights' was ruled out from our classrooms, due to the numerous controversies that it raised, there still remain multiple individual and institutional initiatives that aim to form responsible, active and critical citizens. In general terms, however, it is clear there has been a backward step in this respect, especially because as an essential ingredient of democracy, controversial issues should be seen as opportunities or stimuli for learning, not as topics to be avoided or censored. Finally we recommend, among other things, to reinstate citizenship education as a compulsory subject (not as an alternative to religious education); to amend the current scientism, and other flaws, of our current legislation; to improve teachers' preparation for citizenship and values education, especially for a constructive handling of controversial issues (this requires clarification of the meaning of 'curricular free speech' among us); and to foster systematic research and dissemination efforts to optimize the civic qualities of our school cultures.
Theatrical realism in manga: Performativity of gender in Minako Narita's Alien Street
Authors: Anan Nobuko 
Published: December 2019

Abstract
This article examines different conceptions of realism in theatre and manga by focusing on gender performance in Minako Narita's manga, Alien Street (1980–84). It depicts a male actor who plays female roles in realist theatre productions. I argue that the believability of this gender performance stems in part from the conventions of manga realism, where non-realistic signs are used to mark gender distinctions. However, in contrast to these conventions, this manga also highlights the performative nature of gender by revealing how a realist stage forces the performers to cite and repeat the conventional gendered practices. In doing so, Alien Street mixes manga and theatre realism and complicates our understanding of gender conventions.
Adaptation in Japanese media mix franchising: Usagi Drop from page to screens
Authors: Denison Rayna 
Published: December 2019

Abstract
Japanese media franchising is normally discussed in relation to long-running chains of serial transmedia production known in Japan as 'media mix'. I argue that this focus on the biggest of Japanese franchises is over-determining how we conceptualize the flows of adaptation in Japanese media culture. Therefore, in this article, I focus on a short-lived franchise based around Yumi Unita's manga Usagi Drop (literally, Bunny Drop, 2009–11) in order to think about the media mix as a set of relational adaptation processes. In the space of just a few months in 2011, this manga about a young man adopting his grandfather's illegitimate daughter became the seemingly unlikely source of a transmedia franchise that included television animation and live action film. Focusing on such a short-lived cycle of production allows me to reconsider how Japanese franchise media texts relate to one another, and to decentre anime as the defacto core medium in Japanese franchising. Expanding the view of Japanese media mix adaptations, I consider how both internal and external factors can influence media franchising and adaptation practices in contemporary Japan. Retracing the production discourses around the creation of the Usagi Drop franchise therefore allows me to reconsider the concept of media mix as adaptation practice and process in Japan.
Interpretative negotiation with gender norms in shōjo manga adaptations of The Changelings
Authors: Oshiyama Michiko , Watabe Kohki 
Published: December 2019

Abstract

The Changelings is a classic work of traditional Japanese literature. In the modern era, it has been adapted into Japanese comics repeatedly. This article examines three shōjo manga, or girls' comics, adaptations of The Changelings published between 1984 and 2018. Taken together, the three manga evidence the different situations in which women were embedded in the 1980s and the 2010s and provide different interpretative alternatives to female readers. Manga adaptations of The Changelings crystallized gender norms in Japanese society and women's responses to and struggles with those norms by taking advantage of the gender-switching plot that originated in the twelfth century.
Laserterapia para tratamento de parestesia do Nervo Alveolar Inferior após extrações de terceiros molares inferiores: Revisão de Literatura / Laser therapy for lower alveolar nerve parestesia after lower thir molar extractions: Literature Review
Authors: Matos Fernanda Xavier , Ladeia Júnior Luciano Ferreira , Ladeia Fernando De Góes 
Published: December 2019

A laserterapia consiste na terapia para tratar algumas situações clínicas, como a parestesia, por meio de uma fonte de luz de baixa potência, com a finalidade de regenerar o tecido afetado, assim como aliviar os possíveis sintomas dolorosos. Nesse sentido, este estudo tem por objetivo relatar, por meio de uma revisão de literatura, como a terapia por meio do laser pode se tornar benéfica em casos de parestesia do Nervo Alveolar Inferior, nos casos de extrações de terceiros molares inferiores. Foram, então, pesquisados artigos dos últimos 6 anos, nas diversas bases de dados online, com descritores específicos, a fim de realizar uma revisão de literatura completa. Os artigos encontrados foram selecionados conforme os critérios de inclusão e exclusão pré-estabelecidos, dando início à escrita do trabalho. No procedimento de exodontia dos terceiros molares inferiores é comum algumas intercorrências, como a lesão do Nervo Alveolar Inferior, o que pode provocar uma parestesia. Essa situação pode se tornar um desafio, no que tange a sua terapia. Diante dos artigos analisados, observa-se que o tratamento com fonte de luz, a laserterapia, tem se tornado um tratamento em potencial para esses casos.