bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends and projections of the burden of disease for male infertility in China from 1990 to 2021: an analysis from the Global Burden of Disease 2021 study
Authors: Xu Ran , Wang Xin-jun , Lin Qing-cheng , Zhuang Yan-ting , Zhou Qing-ying , Xu Nai-fen , Zheng Ding-qin 
Published: December 2024

BackgroundCurrently, male infertility represents a serious disease burden worldwide, and China is one of the most affected countries. The aim of this study was to examine the evolution of the disease burden of male infertility in China during the period 1990–2021 and to project the trend for 2022–2036.MethodsBy screening and processing data from the Global Burden of Disease 2021, this study obtained data on the prevalence, disability-adjusted life years and corresponding rates and age-standardised rates of male infertility between 1990 and 2021. To assess the trend in the burden of male infertility over the past 30 years, the annual percentage change and the average annual percentage change were calculated from the above data using Joinpoint regression models. In addition, age-period-cohort models were used to estimate the independent effects of age, period and cohort factors on male infertility, and Bayesian projection models were used to predict the trend in the disease over the next 15 years.ResultIn both 1990 and 2021, the burden of male infertility tended to increase and then decrease with age, with the heaviest burden in the 35–39 age group. Meanwhile, the Joinpoint model found statistically significant average annual percentage changes in age-standardised prevalence and age-standardised disability-adjusted life years of 0.14% and 0.19%, respectively. In addition, the trend for both was a gradual increase over time until 1994 and a gradual decrease over time after 1994. In the age-period-cohort analysis model, age, period and cohort effects indicated that 35–39 years, 1997–2001 and 1945–1949 were the years with the highest risk of male infertility. Finally, the Bayesian projection model suggested that the disease burden of male infertility in China would show a decreasing trend over the next 15 years.ConclusionFrom 1990 to 2021, the disease burden of male infertility in China generally increased. However, thanks to a number of factors, including China's proactive health policies and effective management, the burden of disease has continued to decrease in the last decade and is projected to continue declining from 2022 to 2036. To sustain this positive trend, it remains essential for China to maintain and strengthen effective management and control of male infertility.
Immunoproteasome inhibition reduces donor specific antibody production and cardiac allograft vasculopathy in a mouse heart transplantation model
Authors: Schwalb Allison M. , Anwar Imran , DeLaura Isabel , Ladowski Joseph M. , Yoon Janghoon , Belloni Rafaela , Song Mingqing , Glass Carolyn , Wang Jun , Knechtle Stuart , Kwun Jean 
Published: December 2024

ObjectiveCardiac Allograft Vasculopathy (CAV), a process of vascular damage accelerated by antibody-mediated rejection (AMR), is one of the leading causes of cardiac transplant failure. Proteasome inhibitors (PIs) are utilized to treat AMR, however PI-associated toxicity limits their therapeutic utility. Novel immunoproteasome inhibitors (IPIs) have higher specificity for immune cells and have not been investigated for AMR in cardiac transplant patients. We sought to evaluate IPI effect on AMR in a murine cardiac transplant model.MethodsFully MHC mismatched C57BL/6 to huCD52Tg heterotopic heart transplantations were performed. Recipients were treated with alemtuzumab (10 µg, IP) on days −2, −1, 2, and 4 and anti-CD25mAb (PC61, 100 µg, IP) on day 7 to accelerate AMR with or without IPI (ONX-0914,15 mg/kg, SQ), administered on transplant day and three times a week thereafter.ResultsAnimals without IPI gradually developed post-transplant donor-specific antibody (DSA) and showed a significantly elevated DSA level compared to animals receiving IPI. (TFXM 48.86 vs. 14.17; p = 0.0291, BFXM 43.53 vs. 6.114; p = 0.0031). Accordingly, H&amp;E staining of allograft showed reduced evidence of AMR with IPI compared to controls (P = 0.0410). Notably, increased mortality was observed in the IPI treated group.ConclusionThis study demonstrated the ability of ONYX-0914, an IPI, to control post-transplant DSA production and the AMR development in a heart transplant model. However, IPI-resistant DSA production was also observed and increased mortality with IPI therapy raises concerns about potential toxicity. Further investigation is warranted to assess the utility and potential risk associated with the use of IPI as a post-transplant maintenance immunosuppression.
Reliability agreement in foul and penalty judgements between officials in the Swedish hockey league
Authors: Björklund Glenn , Procter Olivia , Swarén Mikael 
Published: December 2024

IntroductionOfficials are essential in terms of player safety and injury prevention, especially in contact team sports such as ice hockey, where numerous fast pace and high force contacts occur. If against the rules, these collisions can result in penalties. However, there is limited literature on the inter-rater reliability of the officials’ decisions. Hence, the purpose was to investigate the theoretical reliability agreement between professional ice hockey officials in the Swedish Hockey League (SHL).MethodFifty video clips with different match situations were shown to 33 professional ice hockey officials in the SHL. Each situation was shown three times and the officials had 20 s between each video clip to answer which offence and penalty they would judge. The answers were anonymously collected using an online questionnaire. Fleiss’ kappa was used to assess the reliability agreement between the referees, for each situation.ResultsThe Fleiss’ kappa values for all officials were 0.63 and 0.35 for offences and penalties, respectively. Referees and linesmen had similar kappa values for offences (0.64 vs. 0.64), as well as for penalties (0.38 vs. 0.35).ConclusionThe results show that the suggested methodology can be used to identify situations where officials agree and disagree. In ice hockey, poor agreement regarding penalties can depend on the chosen offence as the rulebook limits the availability of penalties, based on the chosen offence. This can create issues, as there are situations where different offences are equally correct but will result in different penalties.
Structural changes of the multifidus in animal models of intervertebral disk degeneration: a systematic review
Authors: Wang Yaobin , Zhao Xinghua , Zhang Xiangyu , Yang Yuhua , Zhang Weikang , Liu Shaocheng , Liu Zhenlei , Zhang Lei , Wang Kai , Wu Hao 
Published: December 2024

Study designLow back pain (LBP) is a widespread clinical symptom affecting nearly all age groups and is a leading cause of disability worldwide. Degenerative changes in the spine and paraspinal tissues primarily contribute to the etiology of LBP.ObjectivesWe conducted this systematic review of animal models of paraspinal muscle (PSM) degeneration secondary to degenerative intervertebral disc (IVD), providing a comprehensive evaluation of PSM structural changes observed in these models at both macroscopic and microscopic levels.MethodsPubMed, EMBASE, Web of Science, Cochrane Library, and MEDLINE Ovid databases were searched through November 2023. Literature was sequentially screened based on titles, abstracts, inclusion of animal models and full texts. A manual search of reference lists from all eligible studies was also performed to identify any eligible article. Two independent reviewers screened the articles according to inclusion and exclusion criteria. The risk of bias was assessed using the Systematic Review Centre for Laboratory Animal Experimentation's Risk of Bias tool.ResultsA total of nine studies were included in the final analysis after a comprehensive screening process. The included studies were assessed for various aspects of the multifidus muscle. Given the limited number of studies and the substantial heterogeneity among them, a quantitative meta-analysis was deemed inappropriate.ConclusionsThis systematic review shows a comprehensive analysis of structural changes in the multifidus muscle in animal models of IVD degeneration and offers crucial insights for developing improved rodent models of IVD degeneration and assessing a battery of approaches for multifidus degeneration.
Enhancing Online Safety for Underage Children
Authors: Mahar Sorath , Memon Shahzad , Dhomeja Lachhman Das , Khoumbati Khalil 
Published: December 2024

Social media has greatly affected society as we know it today, most especially to the teenagers and children under the age of 10, termed as ‘underage children’. Which requires a comprehensive understanding of its effects and risks. This study focuses on what parents think about their children’s usage of social media applications. By surveying parents, we aimed to learn more about their beliefs, concerns and how they manage their children’s online activities and experiences. Our research identified a significant gap between parental awareness and their children’s online experiences. This lack of understanding is concerning because social media platforms are ubiquitous. Many parents lack a thorough understanding of the potential risks and challenges their underage children encounter in this digital environment. Additionally, existing safety measures, even within supposedly child-safe platforms like YouTube Kids, focus only on video content, neglecting potential vulnerabilities in other areas. This highlights the necessity for parental perspectives in shaping safer online spaces for minors. Our Proposed model addresses the current limitations by providing a social media experience with integrated parental controls. The proposed model includes features such as content sharing control, message control, Log-in/ Log-out timings, and customizable ad preferences. The model was stimulated by the literature review and a preliminary research study, which adopts a data-driven approach to enhance child safety within digital landscape. Future research should involve user testing of proposed model with focused group discussions, along with their validation and analysis.
Pasteurization and the Potential Anti-Obesity Function of Fermented Beverages: A Significant Increase in Nitrogen-Containing Aromatic Heterocyclic Compound Content
Authors: Wu Xiurong , Wang Ting , Nie Xiangzhen , Wu Yanglin , Wang Jinghan , Wang Haoming , Dai Rui , Liu Ronghan , Cui Yingying , Su Miaoting , Qiu Yang , Yan Xiantao 
Published: December 2024

Obesity is a chronic disease that profoundly impacts human health, and the role of plant-based formulas (PBFs) in combating obesity has garnered significant interest. Studies have revealed that fermentation significantly enhances the taste, aroma, quality, and health benefits of PBF water extract, with pasteurization being the preferred sterilization technology. However, few studies have investigated the effects of pasteurization on the active components and potential functions of PBF water extract fermentation broth. To examine the impact of pasteurization on fermented water extract of Millettia speciosa Champ (FH08F) and its potential anti-obesity properties, the components of FH08F and thermal-pasteurized FH08F (FH08FS) were analyzed in this study. The analysis revealed a substantial rise in ester content following sterilization. This can be attributed to the acidic environment that promotes the esterification reaction during the heating phase. Network pharmacology was employed to thoroughly examine seven active components of upregulated compounds (URCs) with potential obesity targets, which constituted 92.97% of the total URC content, and four of them were nitrogen-containing aromatic heterocyclic compounds (NAHCs), which accounted for 90.33% of the total URC content. Upregulated NAHCs appear to actively contribute to efficacy against obesity. Molecular docking analyses have shown that theophylline, an NAHC, has the strongest binding affinity with the obesity-related target PTGS2 (Prostaglandin G/H synthase 2, 5FLG). These results imply that theophylline may directly activate PKA/PKG-mediated phosphorylated hormone-sensitive lipase (p-HSL), thereby promoting lipolysis through the cAMP signaling pathway and stimulating the catabolism of triglycerides (TGs) to combat obesity. In conclusion, pasteurization substantially alters the composition of FH08F, and NAHCs are likely to play a significant role in its potential anti-obesity function. These findings provide a scientific foundation for the potential therapeutic effect of FH08FS on obesity and associated metabolic diseases.
General practice community pharmacist consultation service: an exploratory patient survey
Authors: Gauly Julia , Grimley Catherine , Dale Jeremy , Gill Paramjit , Atherton Helen 
Published: December 2024

BackgroundThe General Practice Community Pharmacist Consultation Service (GP CPCS) was established to allow patients with certain minor illnesses to be referred to a community pharmacy for assessment and treatment.AimTo explore patients’ experiences of the GP CPCS.Design & settingAn online survey in two regions of England.Method25 general practices invited patients to take part in an exploratory survey. Descriptive statistics were used for the analysis.ResultsThe response rate was 5.1% (72/1423). Prior to contacting their general practice, 14.1% (9/64) had tried to speak to a pharmacist. Most respondents accepted the CPCS referral (77.3%, 51/66), received a pharmacy consultation on the same day (80.0%, 40/50) and were largely satisfied with the amount of time the pharmacist spent with them (82.5%, 33/40) the consultation format (68.3%, 28/41) and the privacy provided during the consultation (80.9%, 38/47).However, most respondents (56.5%, 39/69) felt poorly informed by the general practice on why they were being advised to speak to a pharmacist and did not feel that it was appropriate that they had been advised to speak to a community pharmacist (54.2%, 39/72). Only 33.3% (16/48) felt that their consultation fully met their health needs and 27.1% (13/48) of patients described being re-referred from pharmacy back to their general practice.ConclusionIn this exploratory study patients were largely accepting of the GP CPCS. Improvements in terms of explaining GP CPCS to patients, selecting patients appropriate for referral to the service and the appointment process may be of benefit.
Um estudo sobre força de interação arbitrária em uma suspensão particulada com restrição de incompressibilidade
Authors: Medeiros Vanessa Daiany Vieira , Libório Denisson de Oliveira , Pagano Rogério Luz , Santos Edilson de Jesus , Silva Antonio Santos 
Published: December 2024

A formulação teórica para um meio poroso com restrição de incompressibilidade, modelado pela teoria contínua de misturas sem reações químicas fornece equações de balanço envolvendo grandezas constitutivas e arbitrárias, quando aplicada ao movimento de uma suspensão particulada. A relação entre grandezas produz várias formas de sistemas de equação para o movimento de tal suspensão. Dentre trais grandezas, pode-se destacar a força de interação arbitrária. Neste trabalho, são estabelecidas informações para a parte arbitrária da força de interação, com base na modelagem matemática do movimento gravitacional de uma suspensão particulada, com restrição de incompressibilidade, em proveta. A base de informações e a expressão para a parte arbitrária da força de interação, apresentadas neste trabalho, envolvem parâmetros básicos produzidos pela modelagem, que podem ser calculados através de dados experimentais da literatura de altura versus tempo da interface superior descendente do próprio teste de proveta, o que resulta numa ferramenta eficaz para obtenção de dados e de resultados numéricos para a parte arbitrária da força de interação, consistindo numa contribuição ao estudo das suspensões particuladas com restrição de incompressibilidade.
СТОКОВО-ЭРОЗИОННАЯ НАПРЯЖЁННОСТЬ НА РАЗНЫХ СЕЛЬСКОХОЗЯЙСТВЕННЫХ УГОДЬЯХ И АГРОФОНАХ
Authors: Панов В.И. 
Published: December 2024

Степной пояс России, включающий в себя ле-состепь, степь и сухую степь, обладает высоким природно-ресурсным потенциалом для успешно-го ведения сельскохозяйственного производства, однако здесь проявляется хронический дефицит влаги с частыми засухами, приводящими к значи-тельной и даже полной потере урожая. Перед сель-скохозяйственной наукой стоит задача повышения биопродуктивности и устойчивости ведения сель-ского хозяйства. В работе рассматривается водный баланс с пози-ции увеличения приходной части и рационального использования расходной части. Показаны результаты теоретических и экспери-ментальных исследований по использованию урав-нений водного баланса талых вод незащищённых и лесомелиорированных агроценозов в качестве алгоритмов (моделей) связи приходно-расходных элементов баланса и применения ландшафтных кластеров (защитно-мелиоративного степного ле-соразведения) воздействия на них для целенаправ-ленного управления эрозионно-гидрологическими процессами.
The steppe zone of Russia, which includes forest-steppe, steppe and dry steppe, has a high natural - resource potential for successful agricultural production, but there is a chronic shortage of moisture with frequent droughts, leading to significant and even complete loss of harvest. Agricultural science faces the challenge of increasing bio-productivity and agriculture sustainability. The water balance is considered from the position of increasing the input part and the rational use of the consumable part. It shows the results of theoretical and experimental studies in terms of the use of the equations of water balance of meltwater of unprotected and forest-reclaimed agrocenoses as algorithms (models) of the connection of input and output the elements of the balance and the use of landscape clusters (protective-meliorative steppe afforestation), and the influence on them for purposeful management of erosion and hydrological processes.
Геоинформационные методы изучения состояния и оценки качества земель сельскохозяйственного назначения в границах муниципального образования
Authors: Денисова Е.В. , Постолов В.Д. 
Published: December 2024

Земельное законодательство устанавлива- ет приоритет охраны сельскохозяйственных угодий, их защиту от неблагоприятного воздей- ствия и разрушения, а также формирует стра- тегию по их сохранению и воспроизводству как основного элемента национального богатства. Ценность земельных ресурсов определяется их плодородием на конкретной хозяйственной ин- фраструктуре и зависит от множества факто- ров. В статье рассматриваются вопросы учета земель, их состояния и охраны качества земель сельскохозяйственного назначения на террито- рии Дуплятского муниципального поселения Но- вониколаевского района Волгоградской области. Применение геоинформационных технологий в границах Дуплятского сельского поселения по- зволило уточнить границы населенных пунктов, входящих в его состав, провести оценку пашни и определить смыв почвы с каждого участка. Сум- марный смыв почвы составляет 22316,5 т на 4932,9 га или 4,5 т/га. Рассмотрение вопросов, изучения состояния и охраны качества земель сельскохозяйственного назначения направлено на формирование современного и перспектив- ного использования земель, при котором будет обеспечиваться наиболее целесообразное и эко- номически выгодное использование земли.
Land legislation sets the priority of protection of agricultural lands, their protection from adverse impacts and destruction, and also forms a strategy for their conservation and reproduction, as the main element of national wealth. The value of land resources is determined by their fertility on a specific economic infrastructure and depends on many factors. The article deals with the issues of land accounting, their condition and quality protection of agricultural land on the territory of the Duplyatsky municipal settlement of Novonikolaevsky district of the Volgograd region. The use of geoinformation technologies within the boundaries of the Duplyatsky rural settlement allowed to clarify the boundaries of the localities that make up it, to assess the arable land and determine the soil washout from each site. The total soil washout is 22316.5 t per 4932.9 ha or 4.5 t / ha. Consideration of issues related to the study of the state and quality of agricultural land is aimed at creating a modern and promising use of land, which will ensure the most appropriate and cost-effective use of land.
Разработка протокола клонального микроразмножения представителей родов Caragána и Cersis в условиях аридной зоны
Authors: Исаков А.С. 
Published: December 2024

С учетом климатических, почвенных и агроэкологических реалий Юга России был разработан рабочий протокол клонального микроразмножения представителей родов Caragána и Cersis в целях защитного ле- соразведения. Процесс клонального микроразмножения включает в себя 4 этапа: процедуру выбора расте- ния-донора для получения хорошо растущей стерильной культуры, лабораторное масштабирование мери- стематических клонов, укоренение размноженных побегов и выращивание растений в условиях теплицы перед высадкой в открытый грунт. Конкретные этапы были соотнесены как с культуральными особенно- стями растений, так и со спецификой их дальнейшего обитания в аридной зоне практически без помощи со стороны человека, но при наличии высокой антропогенной нагрузки в результате примыкающего зем- лепользования. Данный протокол является особенно актуальным для Волгоградской области и обладает новизной, поскольку впервые используются данные виды растений для клонального микроразмножения, и рассматривается процесс их подготовки к естественному произрастанию, выбранные растения могут жить в аридных условиях, без дополнительного внесения влаги.
Taking into account the climatic, soil and agroecological realities of the South of Russia, a working protocol for clonal micropropagation of representatives of the genera Caragána and Cersis for protective afforestation was developed. The clonal micropropagation process includes 4 stages: the procedure for selecting a donor plant to obtain a well-growing sterile culture, laboratory scaling of meristematic clones, rooting of propagated shoots and growing plants in a greenhouse before planting in open ground. Specific stages were correlated both with the cultural characteristics of plants and with the specifics of their further habitation in the arid zone with practically no human assistance, but in the presence of a high anthropogenic load as a result of adjacent land use. This protocol is especially relevant for the Volgograd region and has a novelty, since for the first time these plant species are used for clonal micropropagation, and the process of their preparation for natural growth is considered, the selected plants can live in arid conditions, without additional introduction of moisture.