bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is tumour location a prognostic factor for pharmacological treatment in patients with desmoid-type fibromatosis? a systematic review
Authors: Koike Hiroshi , Hamada Shunsuke , Sakai Tomohisa , Shimizu Koki , Yoshida Masahiro , Nishida Yoshihiro 
Published: May 2020

Abstract

Background
The mainstay of the treatment for desmoid-type fibromatoses has been shifting from surgery to drug treatment, making accurate prediction of the efficacy of drug treatment of extreme importance. On the other hand, desmoid-type fibromatoses arise everywhere in the body. The purpose of this systematic review was to address the clinical question of whether tumour location has an impact on the efficacy of drug treatment.

Methods
A literature search from January 1990 to August 2017 was conducted. Four reviewers independently assessed and screened the literature for eligibility and determined the final articles. They rated each report according to the Grading of Recommendations Development and Evaluation approach. Based on the quality of ‘Body of Evidence’, our clinical guideline committee developed a recommendation for the clinical question.

Results
In total, 128 articles were extracted. After the screenings, 5 were chosen for the final evaluation. The drugs used in these articles were one each of toremifene, sorafenib, and methotrexate and vinblastine and of meloxicam. There were no randomized controlled trials, and two prospective and three retrospective case series were included. Therapeutic effects were observed slightly more markedly in extremity using meloxicam or methotrexate and vinblastine. In contrast, the efficacy of toremifene was slightly higher in non-extremity. However, the evidence level of all of the reports was judged to be low.

Conclusions
Considering the low evidence level, we concluded that the site-specific therapeutic effects of drugs could not be confirmed in desmoid-type fibromatoses.
What is Public about Public Leadership? Exploring ImplicitPublicLeadership Theories
Authors: Vogel Rick , Werkmeister Laura 
Published: May 2020

AbstractWhile scholarship on public leadership has recently gained momentum in public administration, it is unclear how researchers should account for the “public” in public leadership. We shed new light on this issue by introducing the approach of Implicit Leadership Theories (ILTs) to the field of public administration. This socio-cognitive approach suggests that people’s everyday, rather than scholarly, theories about the characteristics of leaders provide important explanations of how they respond to leadership situations. We investigate whether people hold Implicit Public Leadership Theories (IPLTs) and explore how these images of public leaders contrast with generic ILTs. We extract these taxonomies from data gathered in a survey experiment in Germany (N = 1,072). Results show that IPLTs have overlaps with generic ILTs but are unique in terms of rule abidance and innovation-orientation. In contrast, charismatic aspects of leadership only figure in generic ILTs. The structure of ILTs, both generic and public, is surprisingly stable across the subsamples of public and non-public employees. We discuss how the findings may assist public management scholars in the development of explicit theories of public leadership and derive a research agenda based on a socio-cognitive approach.
Sinking skin flap syndrome in the multi-trauma patient: a paradoxical management to TBI post craniectomy
Authors: Hakmi Hazim , Joseph D’Andrea K , Sohail Amir , Tessler Lee , Baltazar Gerard , Stright Adam 
Published: May 2020

Abstract
Sinking skin flap syndrome is a rare syndrome leading to increased intracranial pressure, known to neurosurgeons, yet uncommon and hardly ever reported in trauma patients. In a hospitalized trauma patient with declining neurological status, rarely do we encounter further deterioration by elevating the patients’ head, diuresis and hyperventilation. However, after craniectomy for trauma, a partially boneless cranium may be compressed by the higher atmospheric pressure, that intracranial pressure rises to dangerous levels. For such cases, paradoxical supportive management with intravenous fluid infusion, and reverse Trendelenburg positioning, is used to counteract the higher atmospheric pressure, as a bridge to definitive treatment with cranioplasty. These steps constitute an urgent and easily applied intervention to reduce further neurological deterioration, of which every trauma healthcare provider should be aware.
HRP2–DPF3a–BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription
Authors: Zhu Xu , Lan Bingxue , Yi Xianfu , He Chaoran , Dang Lin , Zhou Xingquan , Lu Yumei , Sun Yongzhan , Liu Zhiheng , Bai Xue , Zhang Kai , Li Bing , Li Mulin Jun , Chen Yupeng , Zhang Lirong 
Published: May 2020

Abstract
Functional crosstalk between histone modifications and chromatin remodeling has emerged as a key regulatory mode of transcriptional control during cell fate decisions, but the underlying mechanisms are not fully understood. Here we discover an HRP2–DPF3a–BAF epigenetic pathway that coordinates methylated histone H3 lysine 36 (H3K36me) and ATP-dependent chromatin remodeling to regulate chromatin dynamics and gene transcription during myogenic differentiation. Using siRNA screening targeting epigenetic modifiers, we identify hepatoma-derived growth factor-related protein 2 (HRP2) as a key regulator of myogenesis. Knockout of HRP2 in mice leads to impaired muscle regeneration. Mechanistically, through its HIV integrase binding domain (IBD), HRP2 associates with the BRG1/BRM-associated factor (BAF) chromatin remodeling complex by interacting directly with the BAF45c (DPF3a) subunit. Through its Pro-Trp-Trp-Pro (PWWP) domain, HRP2 preferentially binds to H3K36me2. Consistent with the biochemical studies, ChIP-seq analyses show that HRP2 colocalizes with DPF3a across the genome and that the recruitment of HRP2/DPF3a to chromatin is dependent on H3K36me2. Integrative transcriptomic and cistromic analyses, coupled with ATAC-seq, reveal that HRP2 and DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of BRG1, the ATPase subunit of the BAF complex. Taken together, these results illuminate a key role for the HRP2-DPF3a-BAF complex in the epigenetic coordination of gene transcription during myogenic differentiation.
Pineal parenchymal tumor of intermediate differentiation: a single-institution experience
Authors: Nam Joo Yeon , Gilbert Andrea , Cachia David , Mandel Jacob , Fuller Gregory N , Penas-Prado Marta , de Groot John , Kamiya-Matsuoka Carlos 
Published: May 2020

AbstractBackgroundPineal parenchymal tumors are exceedingly rare brain tumors responsible for less than 1% of all adult primary intracranial malignancies in the United States. In this study, we describe the clinicopathologic features, management, and outcomes of patients with pineal parenchymal tumor of intermediate differentiation (PPTID).MethodsWe describe a single-center, multidisciplinary team experience in managing PPTID patients over a 15-year period (January 2000 to January 2015) at The University of Texas MD Anderson Cancer Center (MDACC). Pathology was reviewed by the pathology collaborators (A.G. and G.N.F.) and retrospective chart review was performed for treatment and clinical outcomes.ResultsWe identified 17 patients (9 male) with diagnosis of PPTID. Median age at diagnosis of PPTID was 37 years (range, 15-57 years). Follow-up ranged from 0.1 to 162.8 months with 6 reported deaths. Most patients presented with headaches and diplopia. Three patients had neuroaxial dissemination at initial diagnosis, and recurrence of tumor was common (7/16) despite treatment.ConclusionsNo clear prognostic factors were identified in this series. Extension of resection showed a trend toward improved survival. PPTID with neuroaxial dissemination benefits from aggressive initial treatment including craniospinal irradiation and adjuvant chemotherapy, whereas localized disease may be treated traditionally with maximum debulking followed by adjuvant radiotherapy alone. Long-term monitoring is recommended for neurotoxicity and/or late recurrence.
Intensive Longitudinal Study of the Relationship Between Cigalike E-cigarette Use and Cigarette Smoking Among Adult Cigarette Smokers Without Immediate Plans to Quit Smoking
Authors: Pearson Jennifer L , Zhou Yitong , Smiley Sabrina L , Rubin Leslie F , Harvey Emily , Koch Brandon , Niaura Raymond , Abrams David B 
Published: May 2020

Abstract

Introduction
This study examined the association between the introduction of an e-cigarette and subsequent change in cigarette smoking among smokers who were not immediately interested in quitting.

Aims and Methods
The Moment Study was a 21-day intensive longitudinal study with an online follow-up survey at 30 days. After observing baseline cigarette smoking for 1 week, participants received 10 cigalike e-cigarettes on study days 6 and 13. Participants reported cigarettes per day, e-cigarette puffs per day, and e-cigarette satisfaction using text-message-based surveys.

Results
The sample of 96 daily smokers was majority female (53.1%), African American (67.7%), and non-Hispanic (95.8%). When e-cigarettes were provided (day 6), average cigarettes per day dropped by 1.82 cigarettes (p &lt; .0001). The within-person e-cigarette puff effect on daily cigarette smoking was significantly negative (β = −0.023; p = .005); a participant who consumed 100 more e-cigarette puffs in a day than usual for that person was expected to smoke 2.3 fewer cigarettes that day, but this was only true for non-menthol smokers (p = .006). Smokers older than 45 and those who started smoking at a younger age rated e-cigarettes as less satisfying (ps &lt; .05). Participants with greater than the median reported satisfaction were 6.5 times more likely to use an e-cigarette at follow-up.

Conclusions
Giving e-cigarettes to smokers who did not intend to quit reduced their cigarette smoking on days when they used e-cigarette more frequently, but this relationship did not hold for menthol smokers. Satisfaction with e-cigarette use was predictive of continued use 30 days later.

Implications
A greater amount of cigalike e-cigarette use resulted in less smoking among adult daily smokers without immediate plans to quit, but a lack of nicotine delivery and satisfaction for these devices may have limited their utility as a replacement for cigarette smoking, especially among menthol smokers. The global concept of “satisfaction” may be an important driver of e-cigarette use among adult smokers.
International spillover effects of U.S. tax reforms: evidence from Germany
Authors: Christofzik Désirée I , Elstner Steffen 
Published: May 2020

AbstractThis paper explores the international transmission of U.S. tax shocks. Using structural vector autoregressions, we study the impact on the German economy and on German tax legislation. Our results suggest that, after a U.S. tax cut, German GDP increases only moderately. Positive effects via the income channel outweigh negative effects stemming from price developments. Significant changes in the transmission channels arise by distinguishing between the types of the U.S. tax shock. German tax policy either reacts with diametric measures, or remains passive when considering the whole sample period. For a sample starting in 1980, we find that, in particular, after U.S. corporate income tax cuts, tax reductions are also implemented in Germany.
White Matter Governed Superior Frontal Sulcus Surgical Paradigm: A Radioanatomic Microsurgical Study—Part II
Authors: Kassam Amin B , Monroy-Sosa Alejandro , Fukui Melanie B , Kura Bhavani , Jennings Jonathan E , Celix Juanita M , Nash Kenneth C , Kassam Mikaeel , Rovin Richard A , Chakravarthi Srikant S 
Published: May 2020

Abstract

BACKGROUND
Kocher's point (KP) and its variations have provided standard access to the frontal horn (FH) for over a century. Anatomic understanding of white matter tracts (WMTs) has evolved, now positioning us to better inform the optimal FH trajectory.

OBJECTIVE
To (1) undertake a literature review analyzing entry points (EPs) to the FH; (2) introduce a purpose-built WMT-founded superior frontal sulcus parafascicular (SFSP)-EP also referred to as the Kassam-Monroy entry point (KM-EP); and (3) compare KM-EP with KP and variants with respect to WMTs.

METHODS
(1) Literature review (PubMed database, 1892-2018): (a) stratification based on the corridor: i. ventricular catheter; ii. through-channel endoscopic; or iii. portal; (b) substratification based on intent: i. preoperatively planned or ii. intraoperative (postdural opening) for urgent ventricular drainage. (2) Anatomic comparisons of KM-EP, KP, and variants via (a) cadaveric dissections and (b) magnetic resonance-diffusion tensor imaging computational 3D modeling.

RESULTS
A total of 31 studies met inclusion criteria: (a) 9 utilized KP coordinate (1 cm anterior to the coronal suture (y-axis) and 3 cm lateral of the midline (x-axis) approximated by the midpupillary line) and 22 EPs represented variations. All 31 traversed critical subcortical WMTs, specifically the frontal aslant tract, superior longitudinal fasciculus II, and inferior fronto-occipital fasciculus, whereas KM-EP (x = 2.3, y = 3.5) spares these WMTs.

CONCLUSION
KP (x = 3, y = 1) conceived over a century ago, prior to awareness of WMTs, as well as its variants, anatomically place critical WMTs at risk. The KM-EP (x = 2.3, y = 3.5) is purpose built and founded on WMTs, representing anatomically safe access to the FH. Correlative clinical safety, which will be directly proportional to the size of the corridor, is yet to be established in prospective studies.
Enchantment in an Age of Reform: Fortune-Telling Fever in Post-Mao China, 1980s–1990s*
Authors: Baum Emily 
Published: May 2020

Abstract
Soon after the death of Mao Zedong in 1976, China experienced a ‘fortune-telling fever’. After having been suppressed by the Chinese Communist Party for the previous three decades, fortune tellers re-emerged in the 1980s to publish extensively on the topic and ply their trade in public. Yet despite the general relaxation of state policies toward folk beliefs, fortune telling was still considered a ‘superstition’ and therefore remained against the law. To bypass ongoing proscriptions against divinatory practices and publications, fortune tellers began to frame their undertakings in a language that closely mirrored two priorities of the post-Mao state: the advancement of scientific research and the reclamation of traditional culture. As this article argues, the example of China’s fortune-telling fever adds a new perspective to studies that have viewed the resurgence of Chinese spirituality as a form of communal resistance against an atheist regime. Rather than combating the government’s accusation that their practices were superstitious, fortune tellers instead positioned themselves as allies of the state by appealing to its rhetoric of science and cultural nationalism. Downplaying the mystical qualities of their craft, they framed divination as an academic and economic endeavour, one that was both compatible with secular modernity and in keeping with the Chinese Communist Party’s demands for entrepreneurial activity.
On the Perception and Use of Information from Social Media in Investigative Police Work: Findings from a Scandinavian Study
Authors: Rønn Kira Vrist , Rasmussen Bjørn K , Skou Roer Thomas , Meng Christian 
Published: May 2020

Abstract
The purpose of this article is to report from a qualitative Scandinavian study with the aim of shedding some light on how investigators in the Scandinavian police services perceive the use of information from social media in investigative police work. Based on 12 group interviews and 49 informants from Danish, Norwegian, and Swedish police services, we present three overarching themes mirroring the general perception amongst the interviewed investigators that: (1) information from social media is valuable in almost all types of crime investigation; (2) the use of social media information is fraught with technical pitfalls resulting in a general fear of making mistakes; (3) the legal frameworks governing digital investigative action are vague, leading to a feeling amongst the investigators of working in a grey zone. Overall, the informants express the view that this seemingly unregulated part of investigative work requires a major overhaul.
Presenting symptoms, diagnoses and in-hospital mortality in a low resource hospital environment
Authors: Wasingya-Kasereka L , Nakitende I , Nabiryo J , Namujwiga T , Kellett J ,   the Kitovu Hospital Study Group
Published: May 2020

SummaryBackgroundThe relationship between symptoms, signs and discharge diagnoses with in-hospital mortality is poorly defined in low-resource settings.AimTo explore the prevalence of presenting symptoms, signs and discharge diagnoses of medical patients admitted to a low-resource sub-Saharan hospital and their association with in-hospital mortality.MethodsIn this prospective observational study, the presenting symptoms and signs of all medical patients admitted to a low-resource hospital in sub-Saharan Africa, their discharge diagnoses and in-hospital mortality were recorded.ResultsPain, gastro-intestinal complaints and feverishness were the commonest presenting symptoms, but none were associated with in-hospital mortality. Only headache was associated with decreased mortality, and no symptom was associated with increased in-hospital mortality. Malaria was the commonest diagnosis. Vital signs, mobility, mental alertness and mid-upper arm circumference (MUAC) had the strongest association with in-hospital mortality. Tuberculosis and cancer were the only diagnoses associated with in-hospital mortality after adjustment for these signs.ConclusionVital signs, mobility, mental alertness and MUAC had the strongest association with in-hospital mortality. All these signs can easily be determined at the bedside at no additional cost and, after adjustment for them by logistic regression the only diagnoses that remain statistically associated with in-hospital mortality are tuberculosis and cancer.
Human Capital Development and Parental Investment in India
Authors: Attanasio Orazio , Meghir Costas , Nix Emily 
Published: May 2020

AbstractWe estimate production functions for cognition and health for children aged 1–12 in India, based on the Young Lives Survey. India has over 70 million children aged 0–5 who are at risk of developmental deficits. The inputs into the production functions include parental background, prior child cognition and health, and child investments, which are taken as endogenous. Estimation is based on a nonlinear factor model, based on multiple measurements for both inputs and child outcomes. Our results show an important effect of early health on child cognitive development, which then becomes persistent. Parental investments affect cognitive development at all ages, but more so for younger children. Investments also have an impact on health at early ages only.
Coexistence of systemic and localized scleroderma: a systematic literature review and observational cohort study
Authors: Vanhaecke Amber , De Schepper Sofie , Paolino Sabrina , Heeman Lise , Callens Hanne , Gutermuth Jan , Nguyen Sara , Cutolo Maurizio , Smith Vanessa 
Published: May 2020

Abstract

Objective
SSc and localized sclerosis (LoS) are considered clinically distinct entities. We describe herein the coexistence of SSc and LoS by both a systematic literature review and an observational cohort study of unselected SSc patients.

Methods
Original studies documenting the coexistence of SSc and LoS were identified in three electronic databases by means of a systematic literature search according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Additionally, the coexistence of SSc and LoS was studied in a prospective cohort of SSc patients visiting the Ghent University Scleroderma Unit for their yearly follow-up visit between January 2018 and January 2019.

Results
Five studies were finally included for quality appraisal and data extraction. The coexistence of SSc and LoS ranged between 2.4 and 7.4%. RP, scleroderma pattern on nailfold videocapillaroscopy (NVC) and the presence of SSc-specific antibodies were commonly observed in coexistent cases. Additionally, coexistence of SSc and LoS was found in 8/296 (2.7%) consecutive SSc patients of the Ghent University Scleroderma Unit. RP was present in 6/8 coexistent cases; a scleroderma pattern on NVC was observed in all coexistent cases, and SSc-specific antibodies (i.e. cenp-B) were found in 4/8 coexistent cases.

Conclusion
This is the first systematic literature review with additional cohort evaluation investigating the coexistence of SSc and LoS. A relatively high overlap of SSc and LoS was revealed, which is peculiar because both are rare diseases.
Inhibition of hepatocyte growth factor/c-Met signalling abrogates joint destruction by suppressing monocyte migration in rheumatoid arthritis
Authors: Hosonuma Masahiro , Sakai Nobuhiro , Furuya Hidekazu , Kurotaki Yutaro , Sato Yurie , Handa Kazuaki , Dodo Yusuke , Ishikawa Koji , Tsubokura Yumi , Negishi-Koga Takako , Tsuji Mayumi , Kasama Tsuyoshi , Kiuchi Yuji , Takami Masamichi , Isozaki Takeo 
Published: May 2020

Abstract

Objectives
To determine the expression of hepatocyte growth factor (HGF) in RA biological fluids, the role of HGF in monocyte migration and the therapeutic effect of the c-Met inhibitor savolitinib in an arthritis model mice.

Methods
HGF/c-Met expression in serum, SF and synovial tissues (STs) obtained from RA patients and controls, as well as RA fibroblast-like synoviocytes (FLSs), was evaluated by ELISA and immunostaining. To determine the function of HGF in RA SF, we preincubated RA SF with a neutralizing anti-HGF antibody and measured the chemotactic ability of a human acute monocytic leukaemia cell line (THP-1). Additionally, examinations were conducted of SKG mice treated with savolitinib for 4 weeks.

Results
HGF levels in serum from RA patients were significantly higher than those in the controls and were decreased by drug treatment for 24 weeks. Additionally, the HGF level in SF from RA patients was higher than that in SF from OA patients. HGF and c-Met expression was also noted in RA STs. Stimulation of RA FLSs with TNF-α increased HGF/c-Met expression in a concentration-dependent manner, and c-Met signal inhibition suppressed production of fractalkine/CX3CL1 and macrophage inflammatory protein-1α/CCL3. When HGF was removed by immunoprecipitation, migration of THP-1 in RA SF was suppressed. In SKG mice, savolitinib significantly suppressed ankle bone destruction on µCT, with an associated reduction in the number of tartrate-resistant acid phosphatase-positive osteoclasts.

Conclusion
HGF produced by inflammation in synovium of RA patients activates monocyte migration to synovium and promotes bone destruction via a chemotactic effect and enhanced chemokine production.