bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Peptide-Based Neoantigen Vaccine for Patients With Advanced Pancreatic Cancer Refractory to Standard Treatment
Authors: Chen Zheling , Zhang Shanshan , Han Ning , Jiang Jiahong , Xu Yunyun , Ma Dongying , Wang Huimin , Guo Xiaojie , Luo Kai , Qiu Min , Huang Qinxue , Liang Liu , Mo Fan , Chen Shuqing , Yang Liu 
Published: December 2020

Abstract
Background: Tumor-specific neoantigens are considered as personalized and potential ultimate targets for cancer immunotherapy. Recently, neoantigen cancer vaccines have been designed to train the patient's immune system to specifically target and kill tumor cells. However, the safety and efficacy of neoantigen vaccines in pancreatic cancer treatment remain poorly understood. Methods: Personalized peptide neoantigen cancer vaccines were successfully designed and manufactured for pancreatic cancers with low tumor mutation burden. Seven patients with advanced pancreatic cancer refractory to standard treatments were enrolled and treated with personalized peptide neoantigen vaccine, iNeo-Vac-P01. Besides the evaluation of the safety and clinical efficacy of iNeo-Vac- P01, pre- and post-vaccination peripheral blood samples were collected to analyze the vaccine’s immunogenicity.Results: For all 7 patients, none sever vaccine-related adverse effects was witnessed. The mean progression free survival, overall survival (OS) and OS associated with vaccine treatment were 3.1, 24.1 and 8.3 months, respectively. For Patient P01, who had a 21-month OS associated with vaccine treatment, the abundance of the TCR clone remarkably increased after vaccination, indicating the potential of iNeo-Vac-P01 to specifically induce a subset of T cells to kill tumor cells. This study also demonstrated that the quantity of IFN-γ in peripheral blood might be a potential biomarker for OS.Conclusions: We believed that it was the first tentative study focused in the application of peptide-based neoantigen cancer vaccine in advanced pancreatic cancer. Promisingly, personalized peptide neoantigen vaccine might provide a new strategy to improve the limited clinical efficacy for pancreatic cancer.Trial registration: ClinicalTrials.gov, NCT03645148. Registered August 24, 2018 - Retrospectively registered, https://www.clinicaltrials.gov/ct2/show/NCT03645148?term=neoantigen&cond=Pancreatic+Cancer&cntry=CN&draw=2&rank=1
Retos y oportunidades del diseño participativo en tecnología educativa
Authors: Gros Begoña , Durall Eva 
Published: December 2020

El diseño participativo está teniendo una importante incidencia en el diseño de entornos de aprendizaje mediados por tecnología. Cada vez es más frecuente utilizar los enfoques participativos y de codiseño para involucrar a docentes y a estudiantes en el diseño de la tecnología para generar soluciones centradas en las necesidades de las personas que se verán afectadas al utilizarlas. El diseño participativo pretende involucrar a los grupos afectados desde el inicio del diseño, lo que implica tener en consideración la complejidad que supone dar voz a personas con conocimientos, necesidades y roles diferentes. El objetivo principal de esta contribución es analizar el papel actual del diseño participativo con relación a la investigación e innovación en tecnología educativa. Se analiza el origen de este tipo de enfoque y las aplicaciones más habituales en el ámbito educativo. Posteriormente, se describen los métodos que facilitaran la comunicación y colaboración entre las diseñadoras y participantes, se analizan los principios clave en el diseño participativo, y, finalmente, se exponen las implicaciones del diseño participativo para la investigación e innovación en tecnología educativa.
Codiseño educativo haciendo uso de las TIC en educación superior una revisión sistemática de literatura
Authors: Santana Martel Jennifer Saray , Perez-i-Garcias Adolfina 
Published: December 2020

Esta revisión sistemática de literatura (RSL) presenta el análisis bibliométrico de los documentos seleccionados, la forma en que los profesores y los estudiantes co-diseñan dentro del currículo de una asignatura haciendo uso las tecnologías de la información y del conocimiento (TIC) en la educación superior (ES), así como los beneficios y desafíos que surgen en este proceso. Para filtrar los artículos se seleccionaron cuatro criterios de inclusión: fuente (bases de datos Scopus y Redalyc), idioma (español e inglés), periodo de tiempo (2014-2019) y contexto (co-diseño entre profesores y estudiantes haciendo uso de la tecnología dentro del marco de una asignatura en instituciones de ES). Los resultados muestran que no existe un proceso unificado para co-diseñar haciendo uso de las TIC en ES. Además, el co-diseño educativo (CE) muestra varios desafíos, sin embargo, son esos mismos, los que hacen que la asociación entre profesor y alumnado sea beneficiosa. No obstante, para superar estos obstáculos, se sugirieron algunos requisitos a cumplir para el buen funcionamiento del CE. Se recomienda, diseñar un modelo de CE mediado por tecnología educativa que establezca secuencias didácticas, así como, indagar sobre cómo co-diseñar la evaluación entre profesor y estudiante haciendo uso de las TIC.
Strategy for the Alignment of Singapore Flight Information Region Over Indonesian Airspace
Authors: Supriyadi A.A. , Gultom RAG. , Manessa MDM. , Setyanto A. 
Published: December 2020

Introduction:The violation of the Flight Information Region (FIR) over Indonesian airspace is one of the strategic issues related to the sovereignty of Indonesia.Methods:It requires a strategy for the alignment of the Indonesian FIR. One of the difficulties associated with the alignment process is managing the FIR, which is completely determined by the International Civil Aviation Organization (ICAO) owing to safety reasons.Results and Discussion:It is necessary to examine the preparedness and strategy of the Indonesian government to convince the ICAO and the international community that Indonesia is capable of controlling, managing, and securing Indonesian FIR airspace.Conclusion:This study proposes a roadmap for this FIR alignment strategy in an effort to maintain the integrity and sovereignty of the Indonesian region.
Opisthorchosis is a topical health problem (problem overview and analysis)
Authors: Bibik O. I. 
Published: December 2020

The purpose of the research is analyzing literature sources to establish the role of opisthorchosis in health care and assessing the relevance of histological and histochemical methods in determining the eﬃcacy of drugs against helminths which are causative agents of opisthorchosis.Materials and methods. We analyzed literature sources on the study of opisthorchosis, its pathogen spread and its significance for public health. We also reviewed the oﬃcial documentation of the annual reports presented on the oﬃcial websites.Results and discussion. In 2018, more than 19.0 thousand cases of opisthorchosis were recorded in the country (rate is 12.99 per 100 thousand population), which made up 79.5% of all recorded bio-helminthosis in the population. Opisthorchosis is characterized by long course and proceeds with frequent exacerbations. The most serious complication is cancer in the liver, bile ducts and pancreas, which are organs of opisthorchis parasitism. The works of many authors reveal the connection and high incidence of cholangiocarcinoma in patients with opisthorchosis in countries with endemic sites of Opisthorchiidae family representative’s infection. Long-term opisthorchosis infection reduces the eﬃcacy of anthelmintic therapy and leads to the appearance of the disease recurrent forms. Opisthorchis viverrini was oﬃcially recognized as a Group 1 biological carcinogen by the International Agency for Research on Cancer in 2009. The carcinogenic role of O. felineus has not yet been suﬃciently studied. However, life cycles, morphology and localization in the human body of O. viverrini and O. felineus are similar. In the list of established medicinal products with opisthorchocidal action, special attention and interest are paid to herbal products. Histological and histochemical research methods confirmed the eﬃcacy against such herbal preparations as ecorsol, erlim and artemisin.
Papel del tutor en la formación docente
Authors: Espinoza Freire Eudaldo Enrique , Ley Leyva Nelly Victoria , Guamán Gómez Verónica Jacqueline 
Published: December 2020

Las universidades han tenido que plantearse nuevos enfoques de formación, debido a que el proceso de enseñanza-aprendizaje de profesionales, constituye un reto para estas, vislumbrando, sin lugar a dudas, un papel cada vez más protagónico del profesor, en la figura como tutor. En este sentido, el objetivo del presente artículo es analizar el rol del tutor en la carrera de enseñanza básica de la Universidad Técnica de Machala. La investigación es descriptiva, cuanti-cualitativa. Se emplearon los métodos: Analítico-sintético, estadístico y triangulación de datos, así como las técnicas del cuestionario y entrevista en profundidad. Los resultados permitieron determinar que los tutorados perciben las acciones del tutor siempre presentes; consideran sus actividades y resultados de la práctica controlados, y encuentran apoyo para resolver los problemas que enfrentan, visualizando en el tutor como atributos: Dominio de sus funciones, orientación adecuada de la práctica docente, facilitador del proceso de formación; en tanto que, los tutores realizan asesoría de planeación de la práctica docente y observación directa del contexto escolar y áulico del estudiante tutorado. En conclusión, queda claro que la tutoría es un elemento inherente a la función docente y al currículum, sobre todo en el contexto de formación de profesionales de la educación.
Sistema familiar y continuidad de las empresas familiares
Authors: Acosta de Mavárez Ana , Molina Quiroz Claudia A , Andino Chancay Tanya S. , Rodríguez López Virginia E. 
Published: December 2020

Las empresas familiares, aun cuando son similares en muchos aspectos a otras organizaciones que no lo son, presentan diferencias que provienen de la naturaleza explícita del sistema familiar en la propiedad y el control de la empresa. La presente investigación tiene como objetivo analizar elementos del sistema familiar que pueden afectar la continuidad de las empresas familiares. El estudio es de tipo documental-descriptivo, fundamentado en teorías de empresas familiares desarrolladas por autores como: Ward (2003), Gallo y Amat (2003), Chrisman, et al. (2005), Cabrera, et al. (2005; 2014), Amat, et al. (2008), Belausteguigoitia (2010), entre otros. Los hallazgos obtenidos indican que los elementos del sistema familiar que contribuyen con la continuidad de la empresa familiar se relacionan principalmente con el componente humano, los cuales requieren habilidades relacionadas con el liderazgo familiar, la cultura y la capacidad para gestionar las relaciones empresa-familia, en lugar de elementos empresariales y racionales. Se concluye que el desafío del sistema familiar para lograr la continuidad de estas empresas se conecta con la necesidad de contar con estructuras formales de poder compartido; superar modelos tradicionales de sucesión y liderazgo, relacionados con el control patriarcal; y mejorar tanto los procesos de comunicación como el manejo de conflictos.
Micronutrient Deficiencies in Citrus: Iron, Zinc, and Manganese
Authors: Zekri Mongi , Obreza Thomas A. 
Published: December 2020

This document is SL 204, a fact sheet of the Soil and Water Science Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. First printed: January 2003.
SL 204/SS423: Micronutrient Deficiencies in Citrus: Iron, Zinc, and Manganese (ufl.edu)
Enterococcal Urinary Tract Infection in Newborns at a Pediatric Hospital in Saudi Arabia
Authors: Ahmad Shamweel , Alotaibi Hamed Abdullah , Alkhaibari Sultan Hamad , Alshahrani Bassam Mushabab 
Published: December 2020

The main goal of this study was to examine the spectrum of Enterococci that cause urinary tract infection in newborns. This study was conducted during September 2018 to November 2018 at Prince Sattam Bin Abdul Aziz University. A total of 317 urine samples were taken from newborns admitted to the Children's Hospital in the city of Riyadh, Kingdom of Saudi Arabia. In total, 30 (9.5%) Enterococcal strains were isolated from 317 samples. Of these, 17 (56.6%) were from male and 13 (43.4%) were from female patients. From antibiotic sensitivity assay, it was observed that all of the isolates were resistant to clindamycin. But Imipenem and Augmentin were found highly sensitive. So, these sensitive antibiotics can be used for the treatment of newborns UTIs caused by the enterococcal strains.
Dhaka Univ. J. Pharm. Sci. 19(2): 119-124, 2020 (December)
Phytochemical and Biological Studies on Bark Extract of Aporosa wallichii Hook.f.
Authors: Shahriar Kazi Ruhullah , Salekin Sirajis , Islam Quazi Sufia , Ahsan Monira , M Hasan Choudhury 
Published: December 2020

The ethyl acetate extract of bark of Aporosa wallichii Hook.f. was extensively investigated for the chemical characterization of secondary metabolites and for biological activities. After repeated chromatographic separation and purification, two compounds were elucidated as a phenolic compound ferulic acid (1) and an uncommon triterpene glut-5(6)-en-3β-ol (2) from the ethyl acetate extract of barks of A. wallichii by using high field NMR analyses. This is the first report of isolation of both compounds from this plant species. No significant antimicrobial activity was observed for any fraction after Kupchan partitioning of the extract. During the antioxidant activity assay, the ethyl acetate soluble fraction of A. wallichii demonstrated significant DPPH radical scavenging capacity with an IC50 value of 1.25 μg/mL. The other fractions viz. petroleum ether, aqueous and chloroform soluble fractions exhibited moderate, mild, and weak activity respectively. The petroleum ether soluble fraction demonstrated maximum thrombolytic property (51.33%) which was similar to that of standard streptokinase (66.81%).
Dhaka Univ. J. Pharm. Sci. 19(2): 139-143, 2020 (December)
KNOWLEDGE AND ATTITUDES TOWARD PEOPLE WITH DEMENTIA AMONG NURSING STUDENTS IN YOGYAKARTA, INDONESIA
Authors: Sunaryo Salsabilla Rohadatul ‘Aisy , Saifullah Azam David , Mulyani Sri 
Published: December 2020

Background: Nursing students are prepared to deliver care for vulnerable people, including people with dementia. Nursing students tend to have lower levels of knowledge and attitudes toward dementia compared to registered nurses. While there is less evidence that discussed this topic in the Indonesian nursing student's context, it will be necessary to identify an aspect related to knowledge and attitude among students to be considered for improvement in the future.
Objective: This study aimed to identify the knowledge and attitudes toward dementia among nursing students in Indonesia.
Method: This study was a quantitative study with a cross-sectional design. There were 334 nursing students recruited using a total sampling method at Universitas Gadjah Mada, Yogyakarta. Data were collected using the Dementia Knowledge Assessment Scale (DKAS) and Dementia Attitude Scale (DAS). Spearman Rank, Mann Whitney Unpaired, Kruskal-Wallis test, Pearson Correlation, Unpaired t-test, and Unpaired ANOVA were used for data analysis according to the type and the distribution of the data.
Results: The median of the DKAS was 24 (min - max = 7 - 40), and the mean of DAS was 99.60 (SD = 10.25). The variables that were statistically significant correlated to knowledge of dementia were age (r = .332, p < .001), class standing (H = 72.253, p < .001), and experience in taking care of people with dementia (U = 3314, p = .047). Meanwhile, only the age of the students was found to have a statistically significant correlation with attitudes toward dementia (r = 158, p = .004).
Conclusion: In general, among the nursing students, knowledge toward dementia was relatively low, while the attitudes toward dementia were relatively high compared to other research. Age, class standing, and experience in taking care of people with dementia had significant correlations to the knowledge score of the students. Lastly, age also had a significant correlation with the attitude score of the students.
The Effect of Oligopin Supplementation on Hormonal and Metabolic Profiles in the Polycystic Ovary Syndrome: A Randomized Controlled Trial
Authors: Qorbani Mostafa , Sanginabadi Milad , Mohajeri-Tehrani Mohammad Reza , Karimi Sara , Gerami Hadis , Mahdavi-Gorabi Armita , Shirzad Nooshin , Samadi Majid , Baygi Fereshteh , Hosseini Saeed , Mansour Asieh 
Published: December 2020

BackgroundA double blind clinical trial was performed to evaluate whether the polycystic ovary syndrome (PCOS)-specific serum markers and metabolic parameters would change in the women with PCOS during the three-month administration of oligopin.MethodsIn this double-blind multicenter trial, we randomly assigned 80 PCOS women, based on a 1:1 ratio, to receive oligopin (n= 40) or maltodextrin as placebo (n = 40) for up to 3 months. As PCOS-specific outcomes, we investigated the changes in testosterone, sex hormone binding globulin (SHBG), free androgen index (FAI), dehydroepiandrosterone (DHEA), follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Secondary end points were metabolic (fasting glycaemia, hemoglobin A1c (HbA1c), lipids, insulin resistance (HOMA-IR)), anthropometrics parameters and blood pressure from the baseline to the end of treatment. We investigated serum transaminase, alkaline phosphatase (ALP), creatinine (Cr) and blood urea nitrogen (BUN) levels as hepatic and kidney outcomes, respectively.ResultsThe first participant was enrolled on April 18, 2018, and the last study visit took place on May 14, 2019. PCOS-specific serum parameters did not change during the three-month administration of oligopin (p &gt; 0.05), except for a small increase in the FSH levels (p=0.03). Oligopin neither changed the metabolic profile nor the anthropometric parameters or blood pressure. ALP levels was significantly increased in placebo group, as compared with oligopin (p=0.01).ConclusionOligopin supplementation does not seem to be exerting a beneficial effect on both hormonal and metabolic parameters in the women with PCOS.Clinical Trial Registrationwww.irct.ir, identifier IRCT20140406017139N3.
“What About Automated Pain Recognition for Routine Clinical Use?” A Survey of Physicians and Nursing Staff on Expectations, Requirements, and Acceptance
Authors: Walter Steffen , Gruss Sascha , Frisch Stephan , Liter Joseph , Jerg-Bretzke Lucia , Zujalovic Benedikt , Barth Eberhard 
Published: December 2020

Background:Over the last 12 years, the fundamentals of automated pain recognition using artificial intelligence (AI) algorithms have been investigated and optimized. The main target groups are patients with limited communicative abilities. To date, the extent to which anesthetists and nurses in intensive care units would benefit from an automated pain recognition system has not been investigated.Methods:N= 102 clinical employees were interviewed. To this end, they were shown a video in which the visionary technology of automated pain recognition, its basis and goals are outlined. Subsequently, questions were asked about: (1) the potential benefit of an automated pain recognition in clinical context, (2) preferences with regard to the modality used (physiological, paralinguistic, video-based, multimodal), (3) the maximum willingness to invest, (4) preferences concerning the required pain recognition rate and finally (5) willingness to use automated pain recognition.Results:The respondents expect the greatest benefit from an automated pain recognition system to be “to avoid over- or undersupply of analgesics in patients with limited communicative abilities,” a total of 50% of respondents indicated that they would use automated pain recognition technology, 32.4% replied with “perhaps” and 17.4% would not use it.Conclusion:Automated pain recognition is, in principle, accepted by anesthetists and nursing staff as a possible new method, with expected benefits for patients with limited communicative skills. However, studies on automated pain recognition in a clinical environment and proof of its acceptance and practicability are absolutely necessary before such systems can be implemented.
Theta-Burst Stimulation for Cognitive Enhancement in Parkinson's Disease With Mild Cognitive Impairment: A Randomized, Double-Blind, Sham-Controlled Trial
Authors: Lang Stefan , Gan Liu Shi , Yoon Eun Jin , Hanganu Alexandru , Kibreab Mekale , Cheetham Jenelle , Hammer Tracy , Kathol Iris , Sarna Justyna , Martino Davide , Monchi Oury 
Published: December 2020

Background: Mild cognitive impairment is a common non-motor symptom of Parkinson's disease (PD-MCI) and has minimal treatment options.Objective: In this double-blind, randomized, sham-controlled trial, we assessed the effect of repeated sessions of intermittent theta-burst stimulation over the left dorsolateral prefrontal cortex on cognition and brain connectivity in subjects with PD-MCI.Methods: Forty-one subjects were randomized to receive real (n = 21) or sham stimulation (n = 20). All subjects underwent neuropsychological assessments before, 1 day, and 1 month after stimulation. Subjects also underwent resting-state functional magnetic resonance imaging before and 48 h after stimulation. The primary outcome was the change in the cognitive domain (executive function, attention, memory, language, and visuospatial abilities) z-scores across time.Results: There was an insignificant effect on cognitive domain z-scores across time when comparing real with sham stimulation and correcting for multiple comparisons across cognitive domains (p &gt; 0.05 Bonferroni correction). However, the real stimulation group demonstrated a trend toward improved executive functioning scores at the 1-month follow-up compared with sham (p &lt; 0.05 uncorrected). After real stimulation, the connectivity of the stimulation site showed decreased connectivity to the left caudate head. There was no change in connectivity within or between the stimulation network (a network of cortical regions connected to the stimulation site) and the striatal network. However, higher baseline connectivity between the stimulation network and the striatal network was associated with improved executive function scores at 1 month.Conclusions: These results suggest that intermittent theta-burst stimulation over the dorsolateral prefrontal cortex in subjects with PD-MCI has minimal effect on cognition compared with sham, although there were trends toward improved executive function. This intervention may be more effective in subjects with higher baseline connectivity between the stimulation network and the striatal network. This trial supports further investigation focusing on executive function and incorporating connectivity-based targeting.Clinical Trial Registration:www.ClinicalTrials.gov, identifier NCT03243214.