bluuebunny/crossref_metadata_2025_split huggingface dataset:
A COVID–19-betegek kórházon belüli újraélesztésének speciális szempontjai
Authors: László István , Molnár Csilla , Koszta György , Végh Tamás , Fábián Ákos , Berhés Mariann , Juhász Marianna , Fülesdi Béla 
Published: April 2020

Absztrakt:
A koronavírus-pandémia számos kihívással szembesíti az egészségügyi
ellátószemélyzetet. A vírus cseppfertőzéssel terjed, és magas a virulenciája,
ezért minden olyan beavatkozás, mely légúti aeroszolképződéssel jár,
potenciálisan veszélyezteti az ellátásban részt vevők egészségét. A
koronavírus-fertőzés mortalitása akár 10% feletti lehet, ezért a
COVID–19-betegek körében gyakori a reanimáció. A reanimáció során fokozott a
légúti aeroszolképződés valószínűsége, így magas az ellátószemélyzet
fertőződésének a veszélye. Cikkünk célja, hogy gyakorlatorientált áttekintést
adjon a koronavírussal fertőzött betegek újraélesztésének specialitásairól. Orv
Hetil. 2020; 161(17): 710–712.
Protein Kinase C-δ Mediates Kidney Tubular Injury in Cold Storage–Associated Kidney Transplantation
Authors: Zhu Jiefu , Zhang Gang , Song Zhixia , Xiang Xiaohong , Shu Shaoqun , Liu Zhiwen , Yang Danyi , Wei Qingqing , Dong Zheng 
Published: April 2020

Significance Statement
Use of cold storage for organ preservation in kidney transplantation is associated with cold ischemia-reperfusion injury that contributes to delayed graft function and affects the long-term outcome of transplanted kidneys. Using rat proximal tubule cells and a mouse model, the authors demonstrated that protein kinase C-δ (PKCδ), which is implicated in ischemia-reperfusion injury in other organs, is activated in tubular cells during cold storage–associated transplantation and accumulates in mitochondria. There, it mediates phosphorylation of a mitochondrial fission protein, dynamin-related protein 1 (Drp1), at serine 616. Drp1 activation leads to mitochondrial fragmentation, accompanied by mitochondrial damage and kidney tubular cell death. Genetic ablation (in PKCδ-knockout mice) or use of a peptide inhibitor of PKCδ reduced kidney injury in cold storage–associated transplantation, pointing to PKCδ as a promising therapeutic target for kidney transplant.

Background
Kidney injury associated with cold storage is a determinant of delayed graft function and the long-term outcome of transplanted kidneys, but the underlying mechanism remains elusive. We previously reported a role of protein kinase C-δ (PKCδ) in renal tubular injury during cisplatin nephrotoxicity and albumin-associated kidney injury, but whether PKCδ is involved in ischemic or transplantation-associated kidney injury is unknown.

Methods
To investigate PKCδ’s potential role in injury during cold storage–associated transplantation, we incubated rat kidney proximal tubule cells in University of Wisconsin (UW) solution at 4°C for cold storage, returning them to normal culture medium at 37°C for rewarming. We also stored kidneys from donor mice in cold UW solution for various durations, followed by transplantation into syngeneic recipient mice.

Results
We observed PKCδ activation in both in vitro and in vivo models of cold-storage rewarming or transplantation. In the mouse model, PKCδ was activated and accumulated in mitochondria, where it mediated phosphorylation of a mitochondrial fission protein, dynamin-related protein 1 (Drp1), at serine 616. Drp1 activation resulted in mitochondrial fission or fragmentation, accompanied by mitochondrial damage and tubular cell death. Deficiency of PKCδ in donor kidney ameliorated Drp1 phosphorylation, mitochondrial damage, tubular cell death, and kidney injury during cold storage–associated transplantation. PKCδ deficiency also improved the repair and function of the renal graft as a life-supporting kidney. An inhibitor of PKCδ, δV1-1, protected kidneys against cold storage–associated transplantation injury.

Conclusions
These results indicate that PKCδ is a key mediator of mitochondrial damage and renal tubular injury in cold storage–associated transplantation and may be an effective therapeutic target for improving renal transplant outcomes.
Determination of the Factors Affecting High School Students’ Preferences of and Satisfaction with Choosing Biology as an Elective Course
Authors: Ursavas Nazihan , Kesimal Adem 
Published: April 2020

School subjects are divided into two as compulsory and elective courses. Compulsory courses are the basic courses that students must take in order to graduate, while elective courses are the ones that students are at liberty to take. In Turkey Biology course was taught as compulsory under the name of common courses in all levels of high schools. With the new amendment Biology is started to taught as elective under the name of “Advanced Biology” in Anatolian High Schools and “Biology Applications” in Science High Schools at grade eleven and twelve. This new development has brought to mind what the reasons are for choosing and not choosing biology. In order to reveal this aim 135 volunteered students were questioned from two different schools located in the northeastern Turkey. An open-ended question test was used for data collection. The information received from the students was subjected to content analysis. The factors that lead students to choose biology or not to choose biology are identified as future orientedness on both categories. Students want to change their decisions because of course related and exam-orientation reasons. Future studies can utilize larger samples, in terms of gender differences and in the contexts of other elective courses.
Effect of minimally invasive extracorporeal circulation on endothelial dysfunction in cardiac ­surgery patients
Authors: Kornev V I , Kalinina N M , Startseva O N 
Published: April 2020

Aim. To assess the changes in endothelial dysfunction in patients undergoing cardiac surgery with minimally invasive extracorporeal circulation (MiECC).
Methods. The study included 50 patients who were undergoing coronary artery bypass grafting (CABG) surgery with cardiopulmonary bypass (CPB). The patients were divided assigned to either a minimally invasive cardiopulmonary bypass system (group 1, n=15) or standard extracorporeal circuit (group 2, n=35). Changes in the laboratory parameters were assessed 5 times: before the operation, 5 minutes after protamine sulfate administration, 12 hours after the operation, 7 days after the patient's discharged from the hospital and one month after the operation. The activity of von Willebrand factor, factor VIII, and the number of activated platelets were examined in all patients in venous blood.
Results. After protamine sulfate administration, the activity of von Willebrand factor was increased to 164% in the group 1, and up to 193% in the group 2, with a tendency to increase the indicator after 12 hours. The peak of endothelial dysfunction, with the growth of von Willebrand factor and factor VIII, occurs on the 7th day after the operation. In patients of the group with MiECC, von Willebrand factor activity was decreased at the hospital discharge and returned to normal in 1 month. The number of activated platelets increases mainly in group 2 (6% versus 4% in group 1, p=0.29). The expression of P-selectin was significantly higher in group 2 at the hospital discharge (5.5% versus 3.1% in group 1, p 0.001), and in 1 month (4.5% versus 2.3% in group 1, p 0.001).
Conclusion. In patients with minimally invasive cardiopulmonary bypass, platelet activation decreases, endothelial dysfunction, accompanied by an increase in the von Willebrand factor and factor VIII activity, is less pronounced; the seventh day after surgery is a period of the high risk of thrombogenic complications.
The effect of predilation on the incidence of the no/slow-reflow phenomenon in patients with acute coronary syndrome with ST segment elevation
Authors: Sazanov G V , Belokon' O S 
Published: April 2020

Aim. To assess the effect of balloon predilation on the incidence of no/slow-reflow complication during percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEMI).
Methods. We analyzed the experience of the department of endovascular diagnostic and treatment methods of the Stavropol Regional Clinical Hospital for endovascular surgical treatment of patients with STEMI, including after thrombolytic therapy (TLT). The study included 721 patients admitted to the hospital within the first 12 hours from the moment of the first contact with a medical staff. For the study, patients were divided into 2 comparable groups according to the gradation scale TIMI (Thrombolysis in myocardial infarction), comparable the patients' gender, age and other characteristics. Each of the groups also was divided into 2 subgroups according to performing predilation. The study also analyzed the correlation between patients' mortality and existence of the no/slow-reflow phenomenon.
Results. The lowest incidence of the no/slow-reflow phenomenon was in groups in which predilation before stent implantation was not performed. In the group where the blood flow was higher than TIMI 0, the occurrence rate of the no/slow-reflow phenomenon was 7.2 times higher in group with predilation. In the group where the artery was occluded, the risk of the phenomenon during predilation was 3.6 times higher than in group with the tracking method. The risk of mortality in patients with no/slow-reflow phenomenon was 3.9 times higher.
Conclusion. In carrying out the percutaneous coronary intervention, the most preferable is the refusal to perform predilation if there is an appropriate technical feasibility; it is recommended for patients with a blood flow level TIMI 0 to draw a balloon catheter for an occlusion site, which may allow antegrade blood flow to be achieved.
Mujeres indígenas y representación política: la dimensión simbólica de su presencia en el espacio público
Authors: Gigena Andrea Ivanna 
Published: April 2020

<p>El presente artículo aborda la representación política de las mujeres indígenas a partir de considerar su dimensión simbólica. Se parte del supuesto de que los análisis sobre la representación descriptiva y sustantiva de grupos subrepresentados en el Estado (como indígenas y mujeres) son importantes, pero insuficientes para comprender el modo en que se desarrolla la politización y la participación de las mujeres indígenas en el espacio público. Se analiza, entonces, cómo se configura la representación simbólica y los usos que ésta asume entre los pueblos indígenas (como afirmación o como excusa) y en el Estado (como folklorización). El análisis está basado en información secundaria (documental) para la región latinoamericana e información primaria: entrevistas en profundidad e historias de vida realizadas, entre los años 2001 y 2017, a referentes sociales y políticos/políticas de diferentes pueblos indígenas en Argentina, Bolivia, Chile y Panamá.</p>
Master Suppression Techniques and Gender Stereotypes as a Means to Discredit Female Leadership in the Media Representation of a President. A Case Study (Argentina 2011–2015)
Authors: Medina Maria Clara 
Published: April 2020

<p>Este artículo se centra en la representación mediática de Cristina Fernández de Kirchner en las portadas de la revista semanal Noticias durante su segundo mandato como presidenta de Argentina, 2011–2015. A través de una revisión feminista de la evidencia documental, este texto tiene como objetivo determinar los patrones más prevalentes en el uso de técnicas de dominación y estereotipos de género en los medios de comunicación, discutiendo la representación de mujeres políticas en narrativas visuales y escritas, ya que generalmente ésta refuerza los estereotipos de género, perjudicando la imagen pública de las candidatas y representantes femeninas. Los resultados muestran cómo cinco estereotipos de género identificables (el líder narcisista o la diva frívola; la viuda solitaria frente a la viuda malvada; la mujer hipersexualizada o descontrolada; la mujer mentalmente enferma o desequilibrada psíquicamente; y la mujer insopor­table) interactúan con siete técnicas de dominación complementarias (hacer invisible; ridiculizar; retener información; doble constreñimiento o doble castigo; culpar y humillar o avergonzar; objetivar; violencia, fuerza o amenaza de fuerza) para rechazar, subestimar o burlarse del liderazgo político femenino.</p>
Ciencia política y género: una relación en los márgenes de la disciplina
Authors: Martin María Elena 
Published: April 2020

<p>La política y su ciencia están determinadas por el sistema de género vigente. Ello no sólo refleja la exclusión de las mujeres y de las sexualidades disidentes del proceso político real, sino también en la producción científica. Cuando la perspectiva de género ingresa a la disciplina, aporta un cambio epistemológico que consiste en reconocer la significación teórica y política de la diferencia sexual. En este trabajo analizamos la producción de la ciencia política argentina que incorpora esta perspectiva de género a partir de los congresos nacionales y de revistas relevantes de la disciplina en el período 1993–2018.</p>
Comparison of immunohistochemical tests in the CLOVER study by Russian society of clinical oncology
Authors: Zavalishina L. E. , Povilaitite P. E. , Savelov N. A. , Andreeva Yu. Yu. , Petrov A. V. , Raskin G. A. , Kharitonova E. A. , Pugach I. M. , Rumyantsev A. A. , Frank G. A. , Imyanitov E. N. , Tsimafeyeu I. V. , Tjulandin S. A. 
Published: April 2020

Introduction.The goal of the CLOVER study performed by the Russian Society of Clinical Oncology, was a pairwise comparison of three validated PD-L1 immunohistochemical (IHC) tests (Ventana SP142, Ventana SP263, Dako 22C3) in the patient population with non-small cell lung cancer (NSCLC). This study is the first large Russian comparative study to evaluate PD-L1 expression levels using immunohistochemistry methods.Materials and methods.The study was conducted on 473 NSCLC samples from Biobank. The IHC tests were carried out with 3 antibody clones. Four trained pathologists independently evaluated the percentage of positively stained tumor cells (TC) and immune cells (IC). To assess the correlation of TC and IC between different runs and the prognostic values of one test for another, a concordant analysis was used.Results.The number of PD-L1‑positive cells (≥1 %) was higher among IC compared with TC in all three IHC tests. Pearson correlation coefficients (PCC) for TCs were 0.71, 0.87, and 0.75 for 22C3 / SP142, 22C3 / SP263 and SP263 / SP142, respectively. PCC values for ICs were 0.45, 0.61, and 0.68 for the same pairs. A high coincidence of positive and negative results (>91 %) was obtained between the staining with antibodies 22C3 and SP263 of immunooncological agents in the 1st line.Conclusions.The highest correlation between IHC tests was obtained by pairwise comparison of 22C3 and SP263. Clone 22C3 can be considered as a substitute for SP263 in the first-line treatment of NSCLC. Clone SP142 showed weaker expression in TC and IC compared to the other two tests in patients with non-small cell lung cancer.
DEVELOPING THE FUTURE COMMUNITY-BASED TOURISM AT SOF-UMAR CAVE AND ITS ENVIRONS: UNCOVERING CHALLENGES AND OPPORTUNITIES
Authors: Solomon Kebede Nafbek , Kebede Zelelew Ayinalem 
Published: April 2020

Objective: The main aim of this study is to investigate the possible challenges and prospects in developing the future community-oriented tourism at Sof-Umar cave and its environs after examining the contemporary benefits of traditional tourism to the local community. Methodology: The paper opted for a household survey method employing a mixed research approach. The questionnaire, interview and field observation were used as data gathering instruments whereas samples were systematically selected from Sof-Umar kebele. Descriptive and inferential statistics used to analyze the quantitative data. Findings: The findings showed that the study area has enabling factors for the future-proof of tourism to be community-focused despite the challenges that are most commonly experienced in other parts of the country where this type of tourism has been virtually established. Research limitations/implication: Because of the confinement of the objective to the possibility of making the future tourism community-focused, the study does not happen to show the contextual procedure for the development of this niche tourism. Thus, it’s recommended that a straightforward implementation guideline has to be prepared well in advance. Originality/value: This study gives stakeholders fascinating insights into the problems related to the conventional tourism and the need to make the future tourism a community-focused so as to maximize the benefits of the sector and resolve the contemporary conflict.
KONTRIBUSI SEKTOR PARIWISATA TERHADAP PENDAPATAN ASLI DAERAH KABUPATEN JEMBER TAHUN 2011-2017
Authors: Khoir Fawaidul , Ani Hety Mustika , Hartanto Wiwin 
Published: April 2020

Sektor pariwisata merupakan salah satu penunjang Pendapatan Asli Daerah (PAD) di Kabupaten Jember. Tahun 2008 Kabupaten Jember menerapkan pengembangan tiga sektor salah satunya adalah sektor pariwisata. Pengembangan sektor pariwisata bertujuan untuk meningkatkan perekonomian yang akan berdampak pada Pendapatan Asli Daerah. Tujuan dari penelitian ini adalah untuk mengetahui besarnya kontribusi sektor pariwisata terhadap Pendapatan Asli Daerah Kabupaten Jember pada tahun 2011-2017, melihat trend pendapatan dan ramalan pendapatan sektor pariwisata pada tahun-tahun selanjutnya. Penelitian ini merupakan penelitian analisis deskriptif kuantitatif. Penentuan daerah penelitian menggunakan metode purposive area. Hasil analisis kontribusi pada penelitian ini menunjukkan kontribusi sektor pariwisata terhadap PAD yang setiap tahunnya mengalami fluktuatif, meskipun setiap tahunnya pendapatan dari sektor pariwisata selalu mengalami kenaikan. Kontribusi terbesar terdapat pada tahun 2011 yaitu sebesar 3,96%. Kontribusi terbesar ini disebabkan karena pendapatan sektor pariwisata dari penerimaan retribusi tempat parkir khusus cukup besar serta kecilnya peningkatan penerimaan sektor-sektor PAD lainnya yang sah dibandingkan dengan tahun sebelumnya. Sedangkan untuk kontribusi terendah terdapat pada tahun 2017 yaitu sebesar 2,87%. Penurunan ini disebabkan karena peningkatan penerimaan dari sumber Lain-Lain Pendapatan Daerah yang Sah yang sangat tinggi. Sehingga menyebabkan kontribusi sektor pariwisata sangat kecil meskipun total pendapatan dari sektor pariwisata sendiri mengalami kenaikan dibandingkan dengan tahun sebelumnya. Hasil analisis selanjutnya yaitu analisis trend yang menunjukkan ramalan pendapatan pada tahun-tahun selanjutnya akan terus meningkat. Ramalan pendapatan sektor pariwisata Kabupaten Jember pada tahun 2018 sekitar 24,6 M dan akan terus meningkat di tahun-tahun berikutnya.
Cementless Versus Cemented Tibial Fixation in Posterior Stabilized Total Knee Replacement
Authors: Nivbrant Nils Oscar , Khan Riaz J.K. , Fick Daniel P. , Haebich Samantha , Smith Ewan 
Published: April 2020

Background:
Evidence supports the use of cementless tibial component fixation in total knee replacement but there is a paucity of literature on posterior stabilized designs. This randomized study of posterior stabilized total knee replacements compared cemented and cementless tibial fixation with regard to component migration, bone remodeling, and clinical outcomes.

Methods:
This prospective single-center, blinded, randomized clinical trial included 100 patients with a mean age of 68 years (range, 45 to 87 years). Operations were performed by either of 2 experienced arthroplasty surgeons using the Advanced Coated System (ACS) prosthesis (Implantcast). Patients were randomized to cemented or cementless tibial fixation; other variables were standardized. Radiostereometric analysis (RSA) and dual x-ray absorptiometry (DXA) were performed during the inpatient stay and at 3, 12, and 24 months to monitor tibial component migration and periprosthetic bone mineral density (BMD). Clinical scores including the Oxford Knee Score and Short Form-12 were assessed prior to surgery and during follow-up.

Results:
Late and continuing migration was found with cementless fixation. At 24 months, the mean subsidence was significantly greater for the cementless group (1.22 mm) compared with the cemented group (0.06 mm) (p < 0.01). The mean maximum total point motion at 24 months was 2.04 mm for the cementless group and 0.48 mm for the cemented group (p < 0.01). The cemented group had more BMD loss than the cementless group in the medial, lateral, and anterior periprosthetic regions. Two tibial components were revised in the cementless group, including 1 for loosening. Clinical scores improved equally in the 2 groups.

Conclusions:
Late ongoing subsidence and high maximum total point motion in our patients who underwent cementless tibial fixation raise concerns about the fixation stability of ACS cementless posterior stabilized knee replacements. Cemented tibial components were stable. Thus, we advise caution regarding the use of cementless tibial components and recommend tibial fixation with cement for the ACS posterior stabilized total knee replacement.

Level of Evidence:
Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.
Arthroscopic Repair of Large and Massive Rotator Cuff Tears
Authors: Jeong Jeung Yeol , Kim Sung-Jae , Yoon Tae-Hwan , Eum Kwang-Sik , Chun Yong-Min 
Published: April 2020

Background:
The purpose of this retrospective study was to assess the clinical and radiographic outcomes of large and massive rotator tears treated with arthroscopic complete repair with a posterior interval slide compared with partial repair without a posterior interval slide at a minimum follow-up of 5 years.

Methods:
This study included 58 patients with large and massive rotator cuff tears that were unable to be treated with arthroscopic complete repair with an anterior interval slide and margin convergence alone. Each patient underwent either arthroscopic complete repair with an additional posterior interval slide and a subsequent side-to-side repair of the interval slide edge (complete-repair group) or arthroscopic partial repair with margin convergence and without the additional posterior interval slide (partial-repair group). Patient assignment to treatment group was not randomized. Clinical assessments included the visual analog scale pain score, the Subjective Shoulder Value, the American Shoulder and Elbow Surgeons score, the University of California Los Angeles shoulder score, and active range of motion. Preoperative and 6-month follow-up magnetic resonance arthrography (MRA) images were compared within and between groups.

Results:
At the time of the latest follow-up evaluation, both groups had significant improvements in clinical outcomes (p < 0.001). There were no significant differences in the clinical outcomes between groups. A retear was identified in 22 (88%) of the 25 patients in the complete-repair group and 28 (85%) of the 33 patients in the partial-repair group. Patients in the complete-repair group had larger retear sizes (p = 0.001) and reduced acromiohumeral intervals (p = 0.007) compared with those in the partial-repair group.

Conclusions:
Although larger retear size on early postoperative MRA led to significantly reduced acromiohumeral intervals in the complete-repair group, there were no significant differences in clinical outcomes between groups during the minimum 5-year follow-up period. Therefore, it may be preferable to perform partial rotator cuff repair rather than aggressive release in large and massive rotator cuff tears to achieve complete repair.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.