bluuebunny/crossref_metadata_2025_split huggingface dataset:
Near‐Infrared Light‐Induced Spin‐State Switching Based on Fe(II)−Hg(II) Spin‐Crossover Network
Authors: Li Guanping , Stefanczyk Olaf , Kumar Kunal , Guérin Laurent , Okuzono Kosei , Tran Kevin , Seydi Kilic Maximilian , Nakabayashi Koji , Imoto Kenta , Namai Asuka , Nakamura Yuiga , Ranjan Maity Sumit , Renz Franz , Chastanet Guillaume , Ohkoshi Shin‐ichi 
Published: December 2024

AbstractThe development of molecular switches with tunable properties has garnered considerable interest over several decades. A novel spin‐crossover (SCO) material based on iron(II) complexes incorporating 4‐acetylpyridine (4‐acpy) and [Hg(SCN)4]2− anions was synthesized and formulated as [Fe(4‐acpy)2][Hg(μ‐SCN)4] (1). Compound 1 is crystallized in a three‐dimensional network in the non‐centrosymmetric orthorhombic space group Pna21 with two octahedral [Fe(4‐acpy)2(NCS)4] entities featuring two distinct Fe centers (Fe1 and Fe2). Crystallographic, magnetic, and Mössbauer measurements reveal an incomplete SCO exclusively at Fe2, with transition temperature T1/2≈102 K. Photomagnetic studies conducted at 10 K with lasers ranging from 405 to 1310 nm evidence light‐induced excited spin‐state trapping (LIESST) and reverse‐LIESST effects, with a unique near‐infrared‐responsive LIESST phenomenon at 1064 and 1310 nm. Advanced photocrystallographic studies at 40 K provide precise structural evidence for these metastable states. The optical and vibrational properties consistently corroborate with magnetic and photomagnetic studies. Additionally, temperature‐ and light‐dependent terahertz (THz) absorptions are associated with phonon vibrations around Fe2 centers, through SCO behavior, as supported by ab initio calculation. The Fe(II)−Hg(II) systems can be promising benchmarks for exploring synergistic switching effects in structural, magnetic, and spectroscopic properties.
Rapid Screening of Secondary Plant Metabolites using Two‐Dimensional Tandem Mass Spectrometry
Authors: Sams Thomas C. , Ying Sam E. , Edwards Myles Q. , Dziekonski Eric T. , Cooks R. Graham 
Published: December 2024

AbstractThe full 2D tandem mass spectrometry (MS/MS) data domain provides a rapid survey of the chemical components of complex plant extracts without subjecting them to prior chromatographic separation. Nano electrospray ionization (nESI), desorption electrospray ionization (DESI) and paper spray ionization are used to create an ion mixture representative of the chemical constituents of a plant extract, then mass‐selective collision‐induced dissociation (CID) is used to automatically record fragments from each precursor ion in the mixture. Signal extraction from the 2D data domain yields matching spectra to conventional product and precursor ion scans and displays distributions of compounds bearing a chosen functionality. These features and other manipulations of the 2D MS/MS data are demonstrated using crude extracts of Artemisia annua (Sweet wormwood). Similarities and differences in the secondary metabolites of plant species are established rapidly by inspection of the 2D MS/MS plots. The methodology is characterized by the high speed of data acquisition while the limited mass resolution still allows high speed snapshots of chemistry.
Primary Squamous Cell Carcinoma of the Gallbladder: Case Report
Authors: Dashti Sahar , Garousi Maryam , Mirzaee Elahe , Abdi Navid , Sanei Mastaneh 
Published: December 2024

ABSTRACTPure gallbladder squamous cell carcinoma is rare. Adenocarcinoma is the foremost malignant pathology of gallbladder cancer. Simultaneously, squamous cell carcinoma accounts for only 1% of malignant gallbladder tumors. They are often advanced at diagnosis and associated with a poor prognosis. The patient was a 37‐year‐old man diagnosed with poorly differentiated squamous cell carcinoma of the gallbladder. Cholecystectomy, right hemicolectomy, hepatic wedge resection, and regional lymph node dissection were performed, and then he received six courses of adjuvant chemotherapy with the FOLFOX regimen. After 2 months, liver metastasis was diagnosed, and a chemotherapy regimen consisting of gemcitabine, cisplatin, and pembrolizumab was started. After three courses, stable disease was seen. Surgery is the main treatment. There is no consensus about the best adjuvant treatment. The results obtained from this patient might help elucidate the role of adjuvant therapies in treating this rare case report.
A Multidisciplinary Approach to Hypermobility Spectrum Disorder, Raynaud's Phenomenon, and Biomechanical Soft Tissue Injuries in an Adolescent Boy: A Case Report
Authors: Zwiegelaar Su‐ané , Abraham Deepthi R. , Roman Olivia , Welman Karen E. 
Published: December 2024

ABSTRACTA 16‐year‐old male with hypermobility spectrum disorder (HSD) and Raynaud's phenomenon (RP) was referred to a clinical exercise physiologist (CEP) by their pediatric rheumatologist. The patient presented with arthralgia in the left knee and shoulder. Specifically, the left knee presented discomfort during activities of daily living (ADL), and the left shoulder had a reduced range of motion resulting from pain. Finally, complaints of painful fingers were also significant due to increased RP flare‐ups during winter. A posture analysis was conducted, indicating relatively poor posture. Range of motion and manual muscle testing were suboptimal in the shoulders, but optimal in the knees and hips. The Kendal test, patella compression test, and Clarke's sign were conducted due to knee pain. Functional tests included a pelvic bridge, squat, Neer's test, and wall push‐up. Finally, the modified pediatric clinical test of sensory interaction in balance (mPCTSIB) was completed to determine the interaction between balance systems. Analysis of all the tests conducted above confirmed the diagnosis of HSD and also indicated scapula dyskinesia, supraspinatus impingement, and patellofemoral pain syndrome. Consequently, the CEP treatment focused on strengthening the foot, knee, and hip kinetic chain, as a 12‐week home program, along with hand exercises as needed to aid in the pain and stiffness experienced during RP flare‐ups. The physiotherapist treatment was more hands on in the use of myofascial release, electrotherapy, taping, and posture correction of the neck and shoulder over four in‐house visits. Finally, a 6‐month follow‐up was conducted by the CEP, in which the patient showed improvement with a pain‐free range of motion and the ability to optimally conduct ADLs.
Borderline Lepromatous Leprosy With Type 1 Reaction: A Challenging Diagnostic Case
Authors: Saray Polanco Llanes Alondra , Dalit Zajdman Faitelson , Itzel Figueroa Basurto Carla , Montserrat Rodríguez Escamilla Irene , Elisa Vega Memije María , Roberto Arenas Guzmán 
Published: December 2024

ABSTRACTBorderline lepromatous leprosy with Type 1 reaction poses significant diagnostic challenges due to overlapping clinical features. Early recognition and differentiation are crucial, especially in endemic regions like Mexico, to ensure prompt, appropriate management and prevent complications. Accurate diagnosis requires a multidisciplinary approach integrating clinical, histopathological, and microbiological data.
Simultaneous Presentation of Gastric and Orbital Mucosa‐Associated Lymphoid Tissue Lymphoma: A Case Report
Authors: Mirzaee Elahe , Garousi Maryam , Jafari Shima , Soltani Sepideh , Rakhshani Nasser , Abdi Navid , Fadavi Pedram 
Published: December 2024

ABSTRACTMucosa‐associated lymphoid tissue lymphoma or MALToma occurs in 8% of B‐cell non‐Hodgkin lymphoma according to the latest WHO classification. The most involved site of MALToma is stomach. We describe a rare case of concurrent gastric and orbital mucosa‐associated lymphoid tissue lymphoma (MALToma) of a female who presented with progressive proptosis and abdominal pain. We performed six courses of chemotherapy (Rituximab) and gastric and orbital radiation with a dose of 34 Gy/20 Fr and 30 Gy/20 Fr, respectively. This case underscores the efficacy of a multimodal treatment strategy in achieving successful outcomes.
Degradation of rhodamine dye using a modified flow photocatalytic reactor in the presence of external oxidants
Authors: Bagal Manisha , Mane Vijay , Ambulkar Harshal , Gawande Bhumika , Naniwadekar Makarand Y. , Bawankar Kanchan N. , Dange Parmanand N. , Mohod Ashish V. , Gogate Parag R. 
Published: December 2024

AbstractThe current work addresses the challenge of effectively degrading Rhodamine B dye, a common environmental pollutant using a modified zig‐zag flow type photocatalytic reactor with the main objective of process intensification. A detailed study into the effect of initial dye concentration and operating solution pH on the degradation of Rhodamine B elucidated that the Rh B dye degradation was higher at a lower solution pH (pH 2) and at an optimum initial (20 ppm) dye concentration. Among different photocatalysts studied including TiO2, ZnO, and CaO, maximum degradation was seen for the TiO2 with 83.3% at optimum loading of TiO2 (1 g/L). Lower degradations of 76.2% at 1.5 g/L of ZnO and 65.9% at 1.5 g/L of CaO were seen for other photocatalysts. Additionally, the introduction of oxidants such as hydrogen peroxide and Fenton reagent further intensified dye degradation, with the combined UV/Fenton process achieving maximum degradation of 94.8% and the highest COD removal of 68.4%. Overall, it is recommended to utilize zig‐zag flow design photocatalytic reactor with combined Fenton's reagent for optimal dye degradation.
Artificial intelligence–based rapid brain volumetry substantially improves differential diagnosis in dementia
Authors: Rudolph Jan , Rueckel Johannes , Döpfert Jörg , Ling Wen Xin , Opalka Jens , Brem Christian , Hesse Nina , Ingenerf Maria , Koliogiannis Vanessa , Solyanik Olga , Hoppe Boj F. , Zimmermann Hanna , Flatz Wilhelm , Forbrig Robert , Patzig Maximilian , Rauchmann Boris‐Stephan , Perneczky Robert , Peters Oliver , Priller Josef , Schneider Anja , Fliessbach Klaus , Hermann Andreas , Wiltfang Jens , Jessen Frank , Düzel Emrah , Buerger Katharina , Teipel Stefan , Laske Christoph , Synofzik Matthis , Spottke Annika , Ewers Michael , Dechent Peter , Haynes John‐Dylan , Levin Johannes , Liebig Thomas , Ricke Jens , Ingrisch Michael , Stoecklein Sophia 
Published: December 2024

AbstractIntroductionThis study evaluates the clinical value of a deep learning–based artificial intelligence (AI) system that performs rapid brain volumetry with automatic lobe segmentation and age‐ and sex‐adjusted percentile comparisons.MethodsFifty‐five patients—17 with Alzheimer's disease (AD), 18 with frontotemporal dementia (FTD), and 20 healthy controls—underwent cranial magnetic resonance imaging scans. Two board‐certified neuroradiologists (BCNR), two board‐certified radiologists (BCR), and three radiology residents (RR) assessed the scans twice: first without AI support and then with AI assistance.ResultsAI significantly improved diagnostic accuracy for AD (area under the curve −AI: 0.800, +AI: 0.926, p < 0.05), with increased correct diagnoses (p < 0.01) and reduced errors (p < 0.03). BCR and RR showed notable performance gains (BCR: p < 0.04; RR: p < 0.02). For the diagnosis FTD, overall consensus (p < 0.01), BCNR (p < 0.02), and BCR (p < 0.05) recorded significantly more correct diagnoses.DiscussionAI‐assisted volumetry improves diagnostic performance in differentiating AD and FTD, benefiting all reader groups, including BCNR.Highlights
Artificial intelligence (AI)‐supported brain volumetry significantly improved the diagnostic accuracy for Alzheimer's disease (AD) and frontotemporal dementia (FTD), with notable performance gains across radiologists of varying expertise levels.
The presented AI tool is readily clinically available and reduces brain volumetry processing time from 12 to 24 hours to under 5 minutes, with full integration into picture archiving and communication systems, streamlining the workflow and facilitating real‐time clinical decision making.
AI‐supported rapid brain volumetry has the potential to improve early diagnosis and to improve patient management.
Metabolism of Six Novel Nitazenes in Human Liver Microsomes Based on Ultra‐High‐Performance Liquid Chromatography Coupled With High‐Resolution Mass Spectrometry
Authors: Huang Bo‐yu , Hua Zhen‐dong , Liu Cui‐mei , Li Jing , Shu Jian‐Zhao , Li Zhiyu 
Published: December 2024

ABSTRACTSynthetic opioids are a chemically diverse group of substances that function as central nervous system depressants, among which the 2‐benzylbenzimidazole derivatives, also known as nitazenes or nitazene analogs, have recently emerged into the recreational market. The detection of these substances in biological samples largely relies on the acquisition of metabolic data. In this study, the first‐phase metabolism patterns of methylenedioxynitazene, N‐desethyl etonitazene, N‐desethyl methylenedioxynitazene, ethyleneoxynitazene, N‐pyrrolidino etonitazene, and N‐desethyl isotonitazene utilizing human liver microsomes were investigated, and the metabolites were characterized through high‐performance liquid chromatography‐high‐resolution tandem mass spectrometry. Two to eleven metabolites were identified for different nitazene analogs. It was observed that N‐dealkylation, hydroxylation, and dehydrogenation were the major metabolic reactions, with other noteworthy metabolic reactions such as reduction, oxidation, and their combinations also identified. Therefore, it is recommended to use N‐dealkylation and hydroxylation metabolites as analytical markers for monitoring of the intake of these substances.
Edge Computing Enabled Lightweight Neural Network for User Preference Based Customization Recommendation Mechanism
Authors: Li Xianghua , Sun Rui , He Shihua , Wang Chunmei 
Published: December 2024

ABSTRACTThe rapid development of computer and network technologies has led to an explosion of information, ushering in an era of e‐commerce dominated by online shopping. This shift underscores the need for precise, efficient, and customized recommendation systems. Traditional search engines struggle to cater to users' diverse information needs, leading to information overload and “dark information.” The customization recommendation systems emerge as a solution, leveraging user data to discern product correlations and formulate recommendations. However, remote server latency poses a challenge for real‐time recommendations. In this regard, we necessitate the exploration of edge computing and propose an edge computing enabled lightweight neural network for a user preference‐based customization recommendation mechanism including the edge computing based user preference model, the customization preference relevance, and the lightweight neural network‐based customization recommendation. In particular, the user preference model quantifies user affinity toward products and a preference connection pattern that ensures a clean relationship map by mitigating attribute interference, while the customization recommendation integrates back‐propagation for nonlinear input–output mappings, achieving generalization while maintaining efficiency. Experimental results indicate that the proposed mechanism can enhance customization and efficiency in recommendation systems when compared to the state‐of‐the‐art methods in terms of the recommendation accuracy, error rate as well as iterations.
Medication therapy management: The evolution of clinical pharmacy services in U.S. Community‐Based Pharmacy Practice—An opinion of the community‐based practice and research network of the American College of Clinical Pharmacy
Authors: Eddy Emily , Ballou Jordan Marie , Finke Jessica B. , Nuffer Wesley , Avena – Woods Carmela , Bandy Veronica T. , Doucette William , Guthrie Kendall , McDonough Randy , Snyder Margie E. , Varin Jason 
Published: December 2024

AbstractPharmacists in all settings are continually expanding their roles and responsibilities and advocating for the profession. Pharmacists, as medication experts, are trained to identify and resolve medication therapy problems. The act of providing clinical pharmacist expertise is not tied to a specific practice setting, but rather is the mindset in which a pharmacist approaches patient‐centered practice. In community‐based pharmacy settings, pharmacists have been providing clinical services for years through Medication Therapy Management (MTM) and other enhanced services which prioritize quality care. This manuscript will outline the history of the pharmacist's role in managing patients utilizing MTM, present evidence of positive patient care outcomes from pharmacist‐led services in the community‐based setting, and provide recommendations for United States payers to acknowledge and increase payment for pharmacist‐led services. This paper represents the opinion of the Community‐Based Practice and Research Network of the American College of Clinical Pharmacy (ACCP) in the United States. It does not necessarily represent an official ACCP commentary, guideline, or statement of policy or position.
Breaking boundaries: A systematic review of the application of non‐invasive brain stimulation symptoms and sleep parameters in people with ADHD
Authors: dos Santos Renato Mendes , Marinho Victor , de Araújo Val Sabrina Nayara , Teles Ariel Soares , Sousa Daniel Lima , do Vale Bastos Victor Hugo , de Souza Leonardo Peres , de Sousa Angelina Ketllen Cachoeira , de Moraes Gabryella Stefane Firmino , Teixeira Silmar 
Published: December 2024

AbstractBackgroundStudies of non‐invasive treatments such as repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) can contribute in an alternative way to the symptoms treatment and changes in sleep patterns in attention deficit hyperactivity disorder (ADHD), due to some scientific evidence of action on cognition and clinical characteristics.AimThe aim of this systematic review was to evaluate studies of non‐invasive brain stimulation using rTMS and tDCS on symptoms and sleep parameters in people with ADHD, in order to synthesize the main findings on intervention effects.MethodologyA systematic review was carried out using the PRISMA protocol in the PubMed/Medline, Embase, PsycInfo, CINAHL, PEDro and Central—Cochrane library databases were initially carried out on 14 March 2024 and repeated until September 2024. Randomized clinical trials evaluating the effect of rTMS and tDCS on symptoms and changes in sleep pattern in people with ADHD were included. Primary outcomes were total severity of ADHD symptoms and sleep quality assessed by questionnaires and instrument measures.ResultsThe review evidenced only positive findings in five studies for tDCS in some cognitive functions, ADHD symptoms and improvement in sleep parameters, being results with reduced efficacy due to the high heterogeneity in the experimental protocols.ConclusionThe findings show limited evidence; however, it is suggested that the combined use of non‐invasive stimulation with other approaches, such as cognitive training, may improve the intervention effect. It is also important to consider limitations such as heterogeneity in clinical protocols, selection of participants with ADHD, including dosage and frequency. These factors should be explored in future research to optimize the application of these therapies.
Are Bilinguals More Creative Than Monolinguals? A Meta‐Analysis
Authors: Acar Selcuk , Balayar Bhoj , Ozcelik Hatice Nur , Kharkhurin Anatoliy V. 
Published: December 2024

ABSTRACTThis study synthesizes quantitative research on the relationship between creativity and bilingualism. Extant literature underlines the role of developmental, cognitive, and socio‐cultural factors to explain the nature of the relationship between creativity and bilingualism. While decades of research frequently indicate a positive link, contrary or mixed evidence has also been documented, necessitating a comprehensive analysis of existing quantitative data to understand the direction and strength of this relationship. Additionally, identifying factors contributing to inconsistent outcomes is crucial. Thus, we estimated the mean effects and examined various potential sources of variation, including study and participant characteristics, as well as measurement and bilingualism‐related factors, to shed light into the heterogeneity. Addressing these objectives, we analyzed 312 effect sizes from 39 studies (N = 4,917) and found a mean effect size of Pearson r = .181, 95% CI [.096, .263]. This finding shows that bilinguals are overall more creative than monolinguals. Furthermore, a significant difference was observed in the mean effects between test modality categories, with studies using numerical modality reporting significantly larger effect sizes compared to those using action/movement modality. We discuss the findings with research and practical implications.
Metabolomics‐based analysis of nitric oxide regulation of ginseng herb quality
Authors: Zhang Wei , Meng Zhaoping , Yu Pengcheng , Wang Liyang , Liu Wenfei , Song Xiaowen , Yao Yao , Liu Xiubo , Meng Xiangcai 
Published: December 2024

AbstractBACKGROUNDGinsenosides, the primary active ingredients in Panax ginseng, are secondary metabolites. However, their content varies significantly across batches due to differences in environmental conditions and production methods. Ecological stress can increase the levels of reactive oxygen species (ROS) in plants, and ROS can enhance secondary metabolism. Nitric oxide (NO) can promote the production of O2·‐ and H2O2. This study utilized physiological and non‐targeted metabolomics to investigate how NO regulates ginseng quality and how P. ginseng adapts to adversity.RESULTSSodium nitroprusside (SNP, an NO donor) at 0.5 mmol·L−1 significantly increased ROS levels, with O2·‐ increasing by 64.3% (P < 0.01) and H2O2 by 79.2% (P < 0.01). Nitric oxide influenced P. ginseng metabolism, with 24 metabolites showing significant differences. Rotenone, lactic acid, and gluconic acid, which are involved in ROS metabolism, increased significantly, whereas tyrosine decreased. Metabolites involved in secondary metabolic pathways, including campesterol, ginsenosides Rh1, Rb1, Rc, Rd, Rg3, phenylalanine, and tryptophan, increased markedly, whereas 2,3‐oxidosqualene, glucose 1‐phosphate, ferulic acid, and pyrogallol decreased. Isocitric acid, succinic acid, and 3‐isopropylmalic acid, associated with respiratory metabolism, showed significant increases, but pyruvic acid decreased. Finally, 18:0 Lyso PC and 9‐hydroxy‐10E,12Z‐octadecadienoic acid, linked to cell membrane protection, increased significantly, and mannose and raffinose decreased.CONCLUSIONSodium nitroprusside enhances the physiological resilience of P. ginseng under stress and improves its quality. © 2024 Society of Chemical Industry.