bluuebunny/crossref_metadata_2025_split huggingface dataset:
ЗМІНИ ВУГЛЕВОДНОГО ОБМІНУ ПРИ ПІСЛЯОПЕРАЦІЙНІЙ КОГНІТИВНІЙ ДИСФУНКЦІЇ
Authors: Дубівська С. С. , Григоров Ю. Б. 
Published: April 2020

Резюме. Метою дослідження є визначення вмісту основних моніторингових показників обміну вуглеводів у пацієнтів з хірургічною патологією залежно від віку після застосування загального наркозу. Дослідження 130 пацієнтів було проведено в хірургічних відділеннях різного профілю на базі Харківської міської клінічної лікарні швидкої та невідкладної медичної допомоги ім. проф. А.І. Мещанінова.
Оперативне втручання проводили в умовах загальної багатокомпонентної анестезії зі штучною вентиляцією легень з використанням пропофолу і фентанілу, тіопенталу – натрію і фентанілу. Пацієнти були розподілені відповідно на три групи: 1 група (n = 46) – пацієнти молодого віку (18-43 роки); середній вік 30,1 ± 1,0 рік, 24 людини, з них 22 жінки. 2 група (n = 43) – пацієнти середнього віку (44-59 років); середній вік 49,3 ± 5,1 років, 18 чоловіків, 25 жінок. 3 група (n = 41) – пацієнти похилого віку (60-80 років); середній вік 74,4 ± 6,1 року, 22 людини, з них 19 жінок. Відповідно до мети і завдань дослідження у крові пацієнтів визначали основні біохімічні маркери вуглеводного обміну – вміст глюкози, пірувату та лактату.
Відсутність змін показників в крові пацієнтів молодої вікової групи свідчать про те, що для забезпечення гомеостазу глюкози на достатньому рівні працюють гуморальні механізми регуляції вмісту цього моносахариду, який є необхідним для енергетичного забезпечення процесів життєдіяльності організму. Гіперглікемія у пацієнтів середнього віку до операції та у перший тиждень після проведення наркозу та оперативного втручання може бути викликана підвищенням в крові гормонів стресу: адреналіну, кортизолу. Що стосується моніторингового показника стану вуглеводного обміну – глюкози в крові пацієнтів похилого віку, то у них спостерігається гіперглікемія в усі періоди дослідження. Через місяць практично повертається до значень до оперативного втручання. Проте дослідження таких метаболітів анаеробного гліколізу, як піруват і лактат, у сироватці крові пацієнтів різних вікових груп виявило певні особливості змін цих показників, виразність яких залежала від віку та тривалості після наркозу та оперативного втручання.
An Automated Approach for Finding Spatio-Temporal Patterns of Seasonal Influenza in the United States: Algorithm Validation Study
Authors: Sambaturu Prathyush , Bhattacharya Parantapa , Chen Jiangzhuo , Lewis Bryan , Marathe Madhav , Venkatramanan Srinivasan , Vullikanti Anil 
Published: April 2020

Background
Agencies such as the Centers for Disease Control and Prevention (CDC) currently release influenza-like illness incidence data, along with descriptive summaries of simple spatio-temporal patterns and trends. However, public health researchers, government agencies, as well as the general public, are often interested in deeper patterns and insights into how the disease is spreading, with additional context. Analysis by domain experts is needed for deriving such insights from incidence data.

Objective
Our goal was to develop an automated approach for finding interesting spatio-temporal patterns in the spread of a disease over a large region, such as regions which have specific characteristics (eg, high incidence in a particular week, those which showed a sudden change in incidence) or regions which have significantly different incidence compared to earlier seasons.

Methods
We developed techniques from the area of transactional data mining for characterizing and finding interesting spatio-temporal patterns in disease spread in an automated manner. A key part of our approach involved using the principle of minimum description length for representing a given target set in terms of combinations of attributes (referred to as clauses); we considered both positive and negative clauses, relaxed descriptions which approximately represent the set, and used integer programming to find such descriptions. Finally, we designed an automated approach, which examines a large space of sets corresponding to different spatio-temporal patterns, and ranks them based on the ratio of their size to their description length (referred to as the compression ratio).

Results
We applied our methods using minimum description length to find spatio-temporal patterns in the spread of seasonal influenza in the United States using state level influenza-like illness activity indicator data from the CDC. We observed that the compression ratios were over 2.5 for 50% of the chosen sets, when approximate descriptions and negative clauses were allowed. Sets with high compression ratios (eg, over 2.5) corresponded to interesting patterns in the spatio-temporal dynamics of influenza-like illness. Our approach also outperformed description by solution in terms of the compression ratio.

Conclusions
Our approach, which is an unsupervised machine learning method, can provide new insights into patterns and trends in the disease spread in an automated manner. Our results show that the description complexity is an effective approach for characterizing sets of interest, which can be easily extended to other diseases and regions beyond influenza in the US. Our approach can also be easily adapted for automated generation of narratives.
Identifying the Characteristics of Patients With Cervical Degenerative Disease for Surgical Treatment From 17-Year Real-World Data: Retrospective Study
Authors: Zheng Si , Wu Yun Xia , Wang Jia Yang , Li Yan , Liu Zhong Jun , Liu Xiao Guang , Dang Geng Ting , Sun Yu , Li Jiao 
Published: April 2020

Background
Real-world data (RWD) play important roles in evaluating treatment effectiveness in clinical research. In recent decades, with the development of more accurate diagnoses and better treatment options, inpatient surgery for cervical degenerative disease (CDD) has become increasingly more common, yet little is known about the variations in patient demographic characteristics associated with surgical treatment.

Objective
This study aimed to identify the characteristics of surgical patients with CDD using RWD collected from electronic medical records.

Methods
This study included 20,288 inpatient surgeries registered from January 1, 2000, to December 31, 2016, among patients aged 18 years or older, and demographic data (eg, age, sex, admission time, surgery type, treatment, discharge diagnosis, and discharge time) were collected at baseline. Regression modeling and time series analysis were conducted to analyze the trend in each variable (total number of inpatient surgeries, mean age at surgery, sex, and average length of stay). A P value <.01 was considered statistically significant. The RWD in this study were collected from the Orthopedic Department at Peking University Third Hospital, and the study was approved by the institutional review board.

Results
Over the last 17 years, the number of inpatient surgeries increased annually by an average of 11.13%, with some fluctuations. In total, 76.4% (15,496/20,288) of the surgeries were performed in patients with CDD aged 41 to 65 years, and there was no significant change in the mean age at surgery. More male patients were observed, and the proportions of male and female patients who underwent surgery were 64.7% (13,126/20,288) and 35.3% (7162/20,288), respectively. However, interestingly, the proportion of surgeries performed among female patients showed an increasing trend (P<.001), leading to a narrowing sex gap. The average length of stay for surgical treatment decreased from 21 days to 6 days and showed a steady decline from 2012 onward.

Conclusions
The RWD showed its capability in supporting clinical research. The mean age at surgery for CDD was consistent in the real-world population, the proportion of female patients increased, and the average length of stay decreased over time. These results may be valuable to guide resource allocation for the early prevention and diagnosis, as well as surgical treatment of CDD.
Efektifitas Model Pembelajaran Problem Base Learning Berbantukan Multimedia Terhadap Kemampuan Pemecahan Masalah Siswa
Authors: Herijon Muhammad Syahril  , Muhaimin Muhaimin , Ngatijo Ngatijo 
Published: April 2020

[Effectiveness Of Using Multimedia with Problem Base Learning Models to Increase Students Problem Solving Skill].
Penelitian ini bertujuan untuk memperoleh informasi tentang efektifitas pembelajaran. Metode penelitian yang digunakan adalah penelitian campuran jenis Exploratory Sequential Design. Penelitian ini akan mendapatkan data kualitatif dan kuantitatif yang keduanya akan digabung untuk memperoleh data yang lebih rinci dan saling menguatkan. Berdasarkan hasil temuan pada penelitian ini didapatkan bahwa: (1) Kemampuan pemecahan masalah pada kelas PBL berbantuan multimedia lebih tinggi dibandingkan dengan kelas PBL. (2) Multimedia berpengaruh terhadap kemampuan pemecahan masalah siswa dengan nilai uji -t = 0.007. (3) Ketuntasan siswa pada kelas PBL berbantukan multimedia mencapai 88% sedangkan pada kelas PBL mencapai 50%. Dengan demikian dapat disimpulkan bahwa penerapan model PBL berbantuan multimedia efektif meningkatkan kemampuan pemecahan masalah siswa.
Auditor Going Concern Opinions and Bank Systemic Risk: Evidence from the 2007–2009 Financial Crisis
Authors: Albrecht Anne , Glendening Matthew , Kim Kyonghee , Pereira Raynolde 
Published: April 2020

SUMMARY
Following the 2007–2009 financial crisis, regulators and investor groups alleged that auditors were reluctant to issue going concern opinions (GCOs) to distressed banks during the crisis, raising questions about the quality of auditors' GCO decisions. This paper investigates whether systemic risk influences auditors' GCO decisions during the crisis due to potential adverse spillover effects. Using 496 bank-year observations, we find that auditors are less likely to issue a GCO to systemically risky banks, and this auditor behavior reduces Type I errors without increasing Type II errors. The effects are more pronounced during the crisis period, especially for banks that are large and connected, have lower litigation risk, or are audited by Big 4 auditors or industry specialists. Overall, our findings suggest that during the crisis period, auditors were less likely to over-issue GCOs to systemically risky banks, resulting in more accurate GCOs.
JEL Classifications: M42; G20.
Dapagliflozin Versus Placebo on Left Ventricular Remodeling in Patients With Diabetes and Heart Failure: The REFORM Trial
Authors: Singh Jagdeep S.S. , Mordi Ify R. , Vickneson Keeran , Fathi Amir , Donnan Peter T. , Mohan Mohapradeep , Choy Anna Maria J. , Gandy Stephen , George Jacob , Khan Faisel , Pearson Ewan R. , Houston J. Graeme , Struthers Allan D. , Lang Chim C. 
Published: April 2020

OBJECTIVE
To determine the effects of dapagliflozin in patients with heart failure (HF) and type 2 diabetes mellitus (T2DM) on left ventricular (LV) remodeling using cardiac MRI.

RESEARCH DESIGN AND METHODS
We randomized 56 patients with T2DM and HF with LV systolic dysfunction to dapagliflozin 10 mg daily or placebo for 1 year, on top of usual therapy. The primary end point was difference in LV end-systolic volume (LVESV) using cardiac MRI. Key secondary end points included other measures of LV remodeling and clinical and biochemical parameters.

RESULTS
In our cohort, dapagliflozin had no effect on LVESV or any other parameter of LV remodeling. However, it reduced diastolic blood pressure and loop diuretic requirements while increasing hemoglobin, hematocrit, and ketone bodies. There was a trend toward lower weight.

CONCLUSIONS
We were unable to determine with certainty whether dapagliflozin in patients with T2DM and HF had any effect on LV remodeling. Whether the benefits of dapagliflozin in HF are due to remodeling or other mechanisms remains unknown.
Lipid Profile in Indian Patients With Type 2 Diabetes: The Scope for Atherosclerotic Cardiovascular Disease Risk Reduction
Authors: Jayakumari Chellamma , Jabbar Puthiyaveettil Khadar , Soumya Sarayu , Jayakumar R.V. , Das Darvin Vamadevan , Girivishnu Gopi , Gopi Anjana , Gomez Ramesh , Sreenath Ravindranath , Nair Abilash 
Published: April 2020

OBJECTIVE
Reduction of atherosclerotic cardiovascular disease (ASCVD) risk in patients with diabetes requires proper management of lipid parameters. This study aimed to find the pattern of dyslipidemia and scope of ASCVD risk reduction in patients with diabetes by lipid management.

METHODS
Clinical, biochemical, and medication profiles of all patients with diabetes attending a tertiary diabetes care hospital over a 2-year period were collected. The prevalence of various lipid abnormalities was determined after excluding patients with thyroid dysfunction and those on lipid-lowering medications. Patients were stratified according to LDL cholesterol, HDL cholesterol, and triglyceride levels, and other clinical parameters were compared among the groups. The adequacy of statin treatment was assessed based on American Diabetes Association guidelines.

RESULTS
Nine hundred and seventy-one patients were included. The prevalence of hyperlipidemia was 40.0%, of whom 14.6% were newly diagnosed. The most common lipid abnormality was elevated LDL cholesterol. Higher A1C and fasting blood glucose values were found to be associated with higher LDL cholesterol levels. Twenty-seven percent of patients with indications for treatment with statins were receiving them. Of those being treated with statins, 42.6% had an LDL cholesterol level ≥100 mg/dL.

CONCLUSION
In South Indian patients with type 2 diabetes and fair glycemic control, high LDL cholesterol is the predominant lipid abnormality. There remains a huge potential for ASCVD risk reduction in this population if the knowledge practice gap is addressed.
Effect of Tack Cure on Polymerization Shrinkage of Resin-based Luting Cements
Authors: Kim Y-S , Choi S-H , Lee B-N , Hwang Y-C , Hwang I-N , Oh W-M , Ferracane JL , Chang H-S 
Published: April 2020

Clinical Relevance
Self-cure after tack cure could result in a lower polymerization shrinkage in some resin-based luting cements, which is closely related to lower degree of cure.

SUMMARY

Objectives:
To evaluate the effect of tack cure on polymerization shrinkage (PS) of resin-based luting cements.

Methods and Materials:
One composite resin cement, Duo-Link (Duolink); two self-adhesive resin cements, RelyX U200 (U200) and G-CEM LinkAce (GCem); and one resin-modified glass ionomer cement, RelyX Luting Plus (Luting+), were used for measuring PS in light-cure (LC group), self-cure (SC group), and two tack-cure modes that were light cured (TC-LC group) or self-cured (TC-SC group) after tack cure. PS was measured by a modified bonded disc method for 1600 seconds and analyzed with two-way analysis of variance and Tukey honestly significant difference test. To investigate the effect of tack cure on light cure or self-cure, data were analyzed with an independent-samples t-test with tack cure as a variable. The significance level was 5%.

Results:
Regarding cure mode, Duolink showed a significantly lower PS in the TC-SC group compared with the other groups. Luting+ showed a significantly lower PS in the TC-SC group than in the SC group. U200 showed a significantly lower PS in the self-cure groups compared with that in the light-cure groups. The PS of GCem was not affected by cure mode. Regarding cements, Luting+ showed the highest PS, followed by GCem, Duolink, and U200 (p&lt;0.05). Self-cure of Duolink and Luting+ was negatively affected by tack cure, while light cure was not affected. U200 and GCem were not affected by tack cure either in the self-cure or light-cure groups.

Conclusion:
For the tested cements, tack cure decreased the PS of Duolink and Luting+ when they were self-cured after tack cure. When the cements were light cured after tack cure, PS was not affected by tack cure in any cement.
Degree of Conversion Contributes to Dentin Bonding Durability of Contemporary Universal Adhesives
Authors: Tichy A , Hosaka K , Abdou A , Nakajima M , Tagami J 
Published: April 2020

Clinical Relevance
The degree of conversion of contemporary universal adhesives positively correlates with the bond strength to dentin. The correlation is more marked after thermocycling, suggesting that a high degree of conversion is required for long-term dentin bonding durability.

SUMMARY
Purpose: The objectives of this study were to evaluate the micro-tensile bond strength (μTBS) of five contemporary universal adhesives to dentin after 24 hours and thermocycling (TC), to measure their degrees of conversion (DC) and to test the correlation between μTBS and DC.
Methods and Materials: Four commercially available universal adhesives, Prime&Bond universal (PBU), Ecosite Bond (EB), G-Premio Bond (GPB), and Clearfil Universal Bond Quick (UBQ), and one experimental adhesive, UBQ without an amide monomer (UBQ-A), were used in this study. For the μTBS test, midcoronal dentin of 50 human molars was exposed, ground using 600-grit SiC paper, and the adhesives were applied according to the manufacturers’ instructions. After resin-composite buildup and 24-hour water storage, one-half of the specimens were subjected to 15,000 thermal cycles. The specimens were sectioned into beams and stressed in tension at a crosshead speed of 1 mm/min until failure. The DC of adhesives applied to dentin was evaluated using attenuated total reflectance Fourier-transform infrared spectroscopy immediately after light-curing. All data were statistically analyzed at a significance level of 0.05.
Results: The highest μTBSs were obtained with UBQ, UBQ-A, and PBU, which were not significantly different from each other both after 24 hours and TC. The μTBS of GPB was lower compared with the aforementioned adhesives, but significantly only after TC, and the lowest μTBSs were obtained with EB. TC did not affect the μTBSs of UBQ, UBQ-A, and PBU significantly, but a significant decrease was observed with GPB and EB. The highest DC was obtained with PBU and UBQ, followed by 2-hydroxyethyl methacrylate–rich adhesives UBQ-A and EB, which exhibited significantly lower DCs. The DC of GPB could not be determined because the reference peak at 1608 cm−1 was not detected in its spectra. A significant positive correlation was shown between μTBS and DC after 24 hours (r=0.716) and TC (r=0.856).
Conclusion: μTBS and DC were positively correlated, more markedly after TC, which suggests that DC may be an important factor for bond durability.
Perlindungan Hukum Persaingan Usaha Terhadap Indikasi Persekongkolan Tender Jack Up Drilling Rig Services Antara HUSKY-CNOOC MADURA LIMITED Dengan PT COSL INDO (Analisis Putusan KPPU No. 03/KPPU-L/2016)
Authors: Suradiyanto Suradiyanto , Pratiwie Dinny Wirawan 
Published: April 2020

Conspiracy use various way for coordinate activities they like through settings production, determination price horizontally, collusive tendering, division area, division consumer as a non-territorial, and division share market, even though similarly we need realize it that effective conspiracy it is not easy for achieved. However there trend the perpetrators business will always attempted maximizing profit his company respectively. Must there is some requirement in occurrence a conspiracy is must existence deal agreement or collusion between perpetrators effort. There is two form collusion in conspiracy, namely: collusion explicit, where the member communicate and coordinate deal they on real/live can declared with some document agreement already they agree, the data regarding the joint audit, management conspiracy, policies-policies writing, sales data and other data. There is also collusion secretly, where the perpetrators business member conspiracy no communicate on blatant, usually meetings too held on secret. And regular use as the media is association industry, so meetings member conspiracy camouflaged with legal meetings such as meeting associations. Form the second collusion this very difficult for detected by enforcer law. However experience from various country prove that at least 30% of conspiracy is involve associations.
Program Emotional Coaching Menggunakan Tipe Coping Problem Focus Responses dalam Menghadapi Emosi Negatif Anak Intellectual Disability di SLB BC Yatira
Authors: Ningrum Devy Sekar Ayu , Yuspendi Yuspendi , Azizah Endeh 
Published: April 2020

The research will be published in a scientific journal of humanity taken from a thesis research. The purpose of this research is to know emotional coaching program for mother to use coping type problem focus responses in facing negative emotion of child intellectual disability at SLB BC Yatira. The sample in this study were 5 mothers who have children Intellectual Disability. This study is an experimental quasi by using one group pre-post test design. Measurements were made by Coping with Children's Emotion Scale (CCNES) from Fabes and colleagues (1990s), who described coping type of problem focus responsess. Reliability the measuring used expert. The results showed that there were different types of coping mothers in facing the negative emotional child intellectual disability in SLB BC Yatira before and after given emotional coaching program. The statistical test was done by using Wilxocon different test with p = 0,042 <0.05. The conclusion of research there are change of coping type used by mother in facing negative emotion child intellectual disability at SLB BC Yatira after given intervention in the form of emotional coaching program. Practical advice for mothers emotional coaching program can be used by mothers to cultivate a sense of empathy and foster closeness with children, so that mothers can be more positive in the face of negative emotions that children show
Keywords: emotional coaching program, coping type of problem focus responsess, negative emotion in child with intellectual disability
Penurunan Derajat Stres Pegawai Di Lembaga “X” Bandung melalui Pelatihan Coping Resources
Authors: Yuliana Yuliana , Edwina Irene Prameswari , Fun Fun Lie 
Published: April 2020

This research was part of the thesis research and was conducted to find out whether the training of coping resources can reduce the stress level on the employees at organization “X” Bandung. The method used in this research is quasi experimental method with design used in this research is one group design, pre-test and post-test design. Validity test on stress and coping resources questionnaire using construct validity with range of r or rs value for stress questionnaire is 0.418 – 0.874 and for coping resources questionnaire is 0.439 – 0.828 and p-value range for stress questionnaire is 0.000 – 0.047 and for coping resources questionnaire is 0.000 – 0.036. Reliability test on stress and coping resources questionnaire using the formula coefficient reliability alpha cronbach with a value of 0.954 for stress questionnaire and 0.943 for coping resources questionnaire. Based on the results of research shows that training coping resources can reduce the stress level on the employees at Organization “X” Bandung.

Keywords: coping resources, stress, and training