bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Hybrid Recommender System Based-on Link Prediction for Movie Baskets Analysis
Authors: Farashah Mohammadsadegh Vahidi , Etebarian Akbar , Azmi Reza , Dastjerdi Reza Ebrahimzadeh 
Published: December 2020

Abstract
The proposed method in this paper consists of three steps: initial clustering of all users and assigning new user to appropriate clusters, assigning appropriate weights to users' characteristics, and identifying new user’s adjacent users using hybrid similarity criteria and adjacency matrix of adjacent users’ rating to the movie services and calculating new user’s rating to each movie considering adjacent users’ rating and the similarity level of each adjacent user to the new user. The results show that the mean squared error of the proposed model has decreased respectively 8.59%, 8.67%, 8.45% and 8.15% compared to the basic models such as Naive Bayes, multi-attribute decision tree and randomized algorithm. Also, MAE of the proposed method decreased by 4.5% compared to SVD and approximately 4.4% compared to ApproSVD and RMSE of the proposed method decreased by 6.05% compared to SVD and approximately 6.02% compared to ApproSVD.
Modeling Space Radiation Induced Cognitive Dysfunction Using Targeted And Non-Targeted Effects
Authors: Shuryak Igor , Brenner David , Blattnig Steven , Shukitt-Hale Barbara , Rabin Bernard 
Published: December 2020

Abstract
Radiation-induced cognitive dysfunction is increasingly recognized as an important risk for human exploration of distant planets. Mechanistically-motivated mathematical modeling helps to interpret and quantify this phenomenon. Here we considered two general mechanisms of ionizing radiation-induced damage: targeted effects (TE), caused by traversal of cells by ionizing tracks, and non-targeted effects (NTE), caused by responses of other cells to signals released by traversed cells. We compared the performances of 18 dose response model variants based on these concepts, fitted by robust nonlinear regression to a large published data set on novel object recognition testing in rats exposed to multiple space-relevant radiation types (H, C, O, Si, Ti and Fe ions), covering wide ranges of linear energy transfer (LET) (0.22-181 keV/µm) and dose (0.001-2 Gy). The strongest support (by Akaike information criterion) was found for an NTE+TE model where NTE saturate at low doses (~0.01 Gy) and occur at all tested LETs, whereas TE depend on dose linearly with a slope that increases with LET. The importance of NTE was also found by additional analyses of the data using quantile regression and random forests. These results suggest that NTE-based radiation effects on brain function are potentially important for astronaut health and for space mission risk assessments.
Association between insulin-like growth factor 1 and insulin resistance in obese prepubertal boys:a cross-sectional study
Authors: Kuang Jiangying , Zhang Li , Xu Yueqin , Xue Jiang , Liang Shuang 
Published: December 2020

Abstract
Background As one of the most common features of obesity, insulin resistance is central to the pathogenesis of the metabolic syndrome. Low insulin-like growth factor 1(IGF-1) levels have been proven to be associated with many traditional cardiovascular risk factors, but it still remains controversy with the relationship between IGF-1 and insulin resistance. Accordingly, the main purpose of this study is to investigate the relationship between IGF-1 and insulin resistance in obese prepubertal boys.Methods We used whole body insulin sensitivity index (WBISI) to represent insulin resistance. 70 obese prepubertal boys were included in this study, and the obese subjects were divided into two groups by using 1.285 as a threshold value for WBISI. Clinical examination and laboratory examinations were assessed for all participants.Results Among obese boys, the group of children with WBISI ≤ 1.285 had lower IGF-1 standard deviation scores (SDS) (p = 0.021) than WBISI > 1.285 group. The results of multivariate stepwise regression analysis show that WBISI was positively correlated with IGF-1 SDS (β = 1.726, p = 0.002) after adjusting for traditional cardiovascular risk factors.Conclusion IGF-1 SDS was negatively associated with insulin resistance in obese prepubertal boys, independent of other traditional cardiovascular disease risk markers.
Plasma Metabolomic Profiling of Individuals Susceptible to High Altitude through Gas Chromatograph- mass Spectrometry
Authors: Wang Chi , Jiang Hui , Chen Jingwen , Duan Jinyan , Wang Chengbin 
Published: December 2020

Abstract
Objective We aimed to characterize metabolic alterations of people ascending to high altitude and susceptible to acute mountain sickness (AMS). Methods Peripheral blood samples were collected from 36 healthy volunteers on the 3rd day ascending to high altitude (4300m). AMS status was assessed using the Lake Louise Questionnaire. Plasma samples were characterized by gas chromatography-mass spectrometry (GC-MS) and principal component analysis (PCA) was used to discriminate the metabolite changes between sea level and high altitude status and between AMS group and non-AMS group. Results High altitude hypobaric hypoxia caused significant and comprehensive metabolic changes in plasma, including 18 metabolites between sea level and high altitude, 6 metabolites between AMS group and non-AMS group. By using MetaboAnalyst 3.0, several key metabolic pathways were found to be involved, including cysteine and methionine metabolism, alanine, aspartate and glutamate metabolism. Conclusion The GC-MS profiling was a useful approach to analyze metabolites variances and provides potential targets for further investigation to understand the pathophysiological mechanism of hypobaric hypoxia and susceptibility to high altitude.
Development of a New Sternal Dehiscence Prediction Scale for Decision Making in Sternal Closure Techniques After Cardiac Surgery
Authors: Harig Frank , Nooh Ehab , Griesbach Colin , Weyand Michael , Rösch Johannes 
Published: December 2020

Abstract
BackgroundAfter sternotomy, the spectrum for sternal osteosynthesis comprises standard wiring and more complex techniques, like titanium plating. The aim of this study is to develop a predictive risk score that evaluates the risk of sternum instability individually. The surgeon may then choose an appropriate sternal osteosynthesis technique that is risk- adjusted as well as cost-effective.MethodsData from 7.173 patients operated via sternotomy for all cardiovascular indications from 2008 until 2017 were retrospectively analyzed. Sternal dehiscence occurred in 2.5% of patients (n=176). A multivariable analysis model examined pre- and intraoperative factors. A multivariable logistic regression model and a backward elimination based on the Akaike Information Criterion (AIC) a logistic model were selected.ResultsThe model showed good sensitivity and specificity (area under the receiver-operating characteristic curve, AUC: 0.76) and several predictors of sternal instability could be evaluated. Multivariable logistic regression showed the highest Odds Ratios (OR) for reexploration (OR 6.6, confidence interval, CI [4.5-9.5], p <0.001), obesity (body mass index, BMI >35kg/m²) (OR 4.23, [CI 2.4-7.3], p<0.001), insulin-dependent diabetes mellitus (IDDM) (OR 2.2, CI [1.5-3.2], p=0.01), smoking (OR 2.03, [CI 1.3-3.08], p=0.001). After weighting the probability of sternum dehiscence with each factor, a risk score model was proposed scaling from -1 to 5 points. This resulted in a risk score ranging up to 18 points, with an estimated risk for sternum complication up to 74%.ConclusionsA weighted scoring system based on individual risk factors was specifically created to predict sternal dehiscence. High-scoring patients should receive additive closure techniques.
One-Year Outcome after Transcatheter Aortic Valve Replacement for Aortic Regurgitation: A Single-Center Study
Authors: Liu LuLu , Yao Xiaoling , Peng Ying , Huang Weina , Jun Shi , Qian Hong , Chen Yilong , Guo Yingqiang 
Published: December 2020

Abstract
BackgroundPresently, there are limited reports in the literature on the post-operative (mid-term) clinical outcome for pure Aortic Regurgitation (AR) following Transcatheter Aortic Valve Replacement (TAVR).MethodsBetween March 2014 and June 2019, a total of 134 high-risk patients with pure, symptomatic severe AR patients were enrolled in the current study. The outcome was assessed according to the VARC-2 criteria. Procedural results, clinical outcomes, and the patients' hemodynamics for a period of 1-year were analyzed. ResultsPatient mean was 73.1±6.4 years and 25.4% were female. The average STS score was 9.8+5.3%. Procedural success was 97.1% (130/134), and the device success rate was 96.3% (129/134). Five cases were converted to open surgery, while two patients underwent valvular reinterventions (surgical aortic valve replacement for thrombosis and increasing paravalvular regurgitation). The mean aortic valve gradient was 10.2±4.1 mmHg, while the moderate and severe aortic regurgitation was 1.6% at 1 year. Paravalvular regurgitation was none/trivial in 79.8% and mild in 18.5%. The 1-year all-cause mortality rate was 7.4%. At 1-year, the stroke incidence rate was 2.2%. And pacemaker was implanted in 8.9% of the enrolled patients.ConclusionsIn high-risk patients undergoing transapical-TAVR for AR, the use of the J-Valve is safe and effective TAVR should be considered as a reasonable option for high-risk patients with pure AR.
Predictive Value of D-dimer on Mortality in Patients with Acute Aortic Dissection
Authors: Li Shuangshuang , Du Pengcheng , Dong Jian , Zhou Jian , Jing Zaiping 
Published: December 2020

Abstract
ObjectiveTo clarify the relation between D-dimer and in-hospital mortality of acute aortic dissection, a meta-analysis was performed by summarizing all relevant studies.MethodsAll related studies were retrieved and identified in PubMed and Embase databases. Precise data was extracted from standard articles, such as sample size, odds ratio, and 95% confidence interval. Then pooled odds ratio (OR) accompanying 95% confidence interval (CI) were calculated using random model. Study heterogeneity examined by Q text and I2 statistic. Sensitivity analysis was performed to assess the stability of the results. Publication bias was assessed by Egger’s test. ResultsTen studies (1954 patients) that met the inclusion criteria were included in this review. The results suggested a link between D-dimer and in-hospital mortality of acute aortic dissection (OR=1.17 95%CI=1.08-1.27). With higher of cutoff value of D-dimer, the closer for the mortality of AAD, with ORs (95% CIs) ranging from 1.13(1.09–1.16) to 4.12 (1.56–10.93). The relationship was also found in six Type A AAD studies without heterogeneity (OR=1.13 95%CI=1.08-1.18). According to sensitivity analysis, the link was stable after exclusion of one study at a time. Publication bias was find among studies (P=0.02). ConclusionsThe result of this meta-analysis indicated that D-dimer maybe a predictor in-hospital mortality of acute aortic dissection patients. What’s more, the higher of cutoff value of D-dimer, the stronger for the predictive ability.
Non Applicability of Validated Predictive Models for Intensive Care Admission and Death of COVID-19 Patients in a Secondary Care Hospital in Belgium.
Authors: Parisi Nicolas , Janier-Dubry Aurore , Ponzetto Ester , Pavlopoulos Charalambos , Bakalli Gaetan , Molinari Roberto , Guerrier Stéphane , Mili Nabil 
Published: December 2020

Abstract
BackgroundSimple and reliable predictive scores for intensive care admissions and death based on clinical data are still lacking. The goal of this study is to implement such scores based on patients coming from our population catchment area and to compare them to available ones. These scores adhere to the TRIPOD (transparent reporting of a multivariable prediction model for individual prognosis or diagnosis) reporting guidelines.MethodsMonocentric retrospective cohort study run from early March to end of May in Clinique Saint-Pierre Ottignies, a secondary care hospital located in Ottignies-Louvain-la-Neuve, Belgium. The outcomes of the study are (i) admission in the Intensive Care Unit and (ii) death. All patients admitted in the Emergency Department with a positive RT-PCR SARS-CoV-2 test were included in the study. Routine clinical and laboratory data were collected at their admission and during their stay. Chest X-Rays and CT-Scans were performed and analyzed by a senior radiologist. A recently published predictive score conducted on a large scale was used as a benchmark value (Liang score)1. Logistic regressions were used to develop predictive scores for (i) admission to ICU among emergency ward patients; (ii) death among ICU patients on 40 clinical variables. These models were based on medical intuition and simple model selection tools. Their predictive capabilities were then compared to Liang score. ConclusionsOur results suggest that Liang score may not provide reliable guidance for ICU admission and death. Predictive score based on a large-scale Chinese study cannot be applied in the Belgian population, suggesting a predominant role in genetic factors for SARS-CoV-2 susceptibility. In our small cohort, it appears that LDH above 579 UI/L and venous lactate above 3.02 mmol/l may be considered as good predictive biological factors for ICU admission. With regards to death risk, Neutrophil/lymphocyte ratio above 22.1, tobacco abuse status and respiratory impairment appears to be relevant predictive factors. Predictive score for admission to ICU or death based on clinical data are still needed in secondary hospital and hospitals in developing countries that do not have high-performance laboratories. Optimal allocation of resources guided by evidence-based indicators will best guide patients at time of admission and avoid futile treatments in intensive care units.
Influence of Insurance Type on Rate and Type of Initial Concussion-Related Medical Visits among Youth
Authors: Radlicz Chris , Jackson Kenneth , Hautmann Amanda , Shi Junxin , Yang Jingzhen (Ginger) 
Published: December 2020

Abstract
Background: A growing number of studies report increased concussion-related health care utilization in recent years, but factors impacting care-seeking behaviors among youth following a concussion are not well described. This study aimed to evaluate the influence of insurance type on the rate and type of initial concussion visits and the time from injury to the initial visit in youth. Methods: We extracted and analyzed initial concussion-related medical visits for youth ages 10 to 17 from electronic health records. Patients must have visited Nationwide Children’s Hospital’s (NCH) concussion clinic at least once between 7/1/2012 and 12/31/2017. We evaluated the trends and patterns of initial concussion visits across the study period using regression analyses.Results: Of 4,955 unique concussion visits included, 60.1% were males, 80.5% were white, and 69.5% were paid by private insurance. Patients’ average age was 13.9 years (SD=3.7). The rate of the initial concussion visits per 10,000 NCH visits was consistently higher in privately insured than publicly insured youth throughout the study period (P < .0001). Privately insured youth had greater odds of initial concussion visits to sports medicine clinics (AOR = 1.45, 95% CI = 1.20, 1.76) but lower odds of initial concussion visits to the ED/urgent care (AOR = 0.74, 95% CI = 0.60, 0.90) than publicly insured youth. Days from injury to initial concussion visit significantly decreased among both insurance types throughout the study (P < .0001), with a greater decrease observed in publicly insured than privately insured youth (P = .011).Conclusions: Results on the differences in the rate, type, and time of initial concussion-related visits may help inform more efficient care of concussion among youth with different types of insurance.
Influence of Socio-Spatial Determinants on Knowledge, Attitudes and Practices Related to the Plague in Populations Living in Endemic Areas in the Central Highlands of Madagascar
Authors: Rakotosamimanana Sitraka , Rakotoarimanana Feno Jacob , Raharimanga Vaomalala , Taglioni François , Ramamonjisoa Josélyne , Randremanana Rindra Vatosoa , Rajerison Minoarisoa , Rakotomanana Fanjasoa 
Published: December 2020

Abstract
Background: Plague is endemic to the central highlands of Madagascar. Sporadic human cases or outbreaks can occur annually in these areas. In Madagascar, the association between endemicity and the knowledge, attitudes and practices (KAP) of populations with regard to this disease remain poorly documented. The aim of this study was to assess KAP related to the plague of populations living in the central highlands. Methods: A cross sectional survey was conducted among the general population from June to August 2017. Based on the reported cases of plague between 2006 and 2015 in two central highland districts, a KAP questionnaire was administered to the population. Based on the proportion of correct answers provided by respondents, KAP scores were classified into three KAP categories: low (< Mean - SD), average (Mean ± SD) and good (> Mean + SD). Multivariate analyses were performed to determine the associations between population KAP scores related to plague with socio-demographic and epidemiological factors. In addition, individual interviews and focus groups with health professionals were conducted to assess plague perception.Results: A total of 597 individuals participated in the survey. Around 20% (n=119) had a good KAP score, 62% (n=370) an average KAP score and 18% (n=108) a low KAP score. Among the 119 respondents with a good KAP score, 80% (n=95) of them resided in Ambositra district and 20% (n=24) resided in Tsiroanomandidy district. According to the health professionals in the two districts, populations in endemic areas are well aware of the plague. A significant association with a lower KAP score was found in populations without mobile phone, having no contact with a former plague case and living in Tsiroanomandidy district (p<0.05).Conclusion: The results of the study showed the need to adapt plague control interventions to the local context to allow a better allocation of human and financial resources. This will minimize delays in patient management care and increase community resilience to plague epidemics.
Grave Thoraco-Intestinal Complication Secondary to an Undetected Traumatic Rupture of the Diaphragm - A Case Report
Authors: Beshay Morris , Krüger Martin , Singh Kashika , Borgstedt Rainer , Benhidjeb Tahar , Boelke Edwin , Vordemvenne Thomas , Esch Jan Schulte am 
Published: December 2020

Abstract
BackgroundDiaphragmatic lesions as a result from blunt or penetrating trauma are challenging to detect in the initial trauma setting. This is especially true when diaphragmatic trauma is part of a polytrauma. Complications of undetected diaphragmatic defects with incarcerating bowel are rare but as in our patient can be serious. Case presentationA 57-year-old female presented to the Emergency Room of our Hospital in a critical condition with 3 days of increasing abdominal pain. The initial clinical examination showed peritonism with tinkling peristaltic bowel sounds of mechanical obstruction. A thoraco-abdominal CT-scan demonstrated colon prolapsed through the left diaphragmatic center with a large sero-pneumothorax under tension. As the patient was hemodynamically increasingly unstable with developing septic shock an emergency laparotomy was performed. After retraction of the left colon, which had herniated through a defect of the tendinous center of the left diaphragm and was perforated due to transmural ischemia, large amounts of feces and gas discharged from the left thorax. A left hemicolectomy resulting in a Hartmann type procedure was performed. A fully established pleural empyema required meticulous debridement and lavage conducted via the 7-10cm in diameter phrenic opening followed by a diaphragmatic defect reconstruction. Due to pneumonia and recurring pleural empyema redo-debridement of the left pleural space via thoracotomy were required. The patient was discharged on day 56. A thorough history of possible trauma revealed a bicycle-fall-trauma 7 months prior to this hospitalization with a surgically stabilized fracture of the left femur and conservatively treated fractures of ribs 3-9 on the left side. ConclusionThis is the first report on a primarily established empyema at the time of first surgical intervention for faeco-pneumothorax secondary to delayed diagnosed diaphragmatic rupture following abdomino-thoracic blunt trauma with colic perforation into the pleural space, requiring repetitive surgical debridement in order to control local and systemic sepsis. Thorough investigation should always be undertaken in cases of blunt abdominal and thoracic trauma to exclude diaphragmatic injury in order to avoid post traumatic complications.
An Association Rule Analysis of Acupressure Effect on Sleep Quality
Authors: Jia Guhua , Tzeng I-Shiang , Wu Chieh-Chen 
Published: December 2020

Abstract
Background: Sleep is recognized as an all-important physiological process, which also contributes to maintaining several bodily functions and systems. Insufficient sleep can induce many serious side effects and have an impact on human health in general. There are five consequences of lack of sleep, including an increased chance of morbidity and mortality, poor judgment, increased risk of accidents and injuries, reduced level of functioning, and an inferior quality of life. According to the Pittsburgh Sleep Quality Index (PSQI), also known as the most widely used tool in the field of subjective assessment of self-perceived sleep quality, a combination of acupoints could be more effective than single acupoint treatment in improving sleep quality. Methods: This study has been proved based on a previous meta-analysis that consisted of some relevant studies. The present study was based on the extracted randomized control trials (RCTs) rooted in a previous meta-analysis that worked on the basis of association rule mining and examined the potential kernel acupoint combinations for improving sleep quality. Results: Depending on the Apriori algorithm, we summarized 26 acupoints as binary data from the 32 eligible RCTs and analyzed them. The top 10 most frequently selected acupoints were HT7, SP6, PC6, KI1, GV20, Taiyang, Yintang, Anmian, KI3, and Ear Shenmen. Furthermore, as deduced from 21 association rules, the primary relevant rules in the combination of acupoints are {Yintang, Anmian}=>{GV20} and {HT7, KI1}=>{PC6}. Conclusions: In order to use acupuncture to improve sleep quality, integrating {Yintang, Anmian, GV20} with {HT7, KI1, PC6} acupoints could be deemed as the kernel acupoint combination.