bluuebunny/crossref_metadata_2025_split huggingface dataset:
The project REBOOT protocol: Evaluating a personalized inhibitory control training as an adjunct to cognitive behavioral therapy for bulimia nervosa and binge‐eating disorder
Authors: Manasse Stephanie M. , Lampe Elizabeth W. , Gillikin Lindsay , Payne‐Reichert Adam , Zhang Fengqing , Juarascio Adrienne S. , Forman Evan M. 
Published: March 2020

AbstractOutcomes from cognitive behavioral therapy (CBT) for bulimia nervosa (BN) and binge‐eating disorder (BED) are suboptimal. One potential explanation is that CBT fails to adequately target inhibitory control (i.e., the ability to withhold an automatic response), which is a key maintenance factor for binge eating. Computerized inhibitory control training (ICT) is a promising method for improving inhibitory control but is relatively untested in BN/BED. The present study will evaluate a computer‐based ICT as an adjunct to CBT for BN/BED. Participants with BN (n = 30) or BED (n = 30) will be randomized to 12 weeks of either CBT + ICT or CBT + a sham training. Trainings will be completed daily for 4 weeks and weekly for 8 weeks. Primary aims include the following: (a) confirm target engagement (evaluate whether ICT improves inhibitory control), (b) test target validation (evaluate whether improvements in inhibitory control are associated with improvements in binge eating), and (c) evaluate the incremental efficacy of ICT on binge eating. Secondary aims include the following: (a) evaluate ICT feasibility and acceptability and (b) assess the moderating effects of approach tendencies on highly palatable food, dietary restraint, and diagnosis. Data will be used to shape a fully powered clinical trial designed to assess efficacy and dose–response effects of ICT for BN/BED.
Population‐specific effect of Wolbachia on the cost of fungal infection in spider mites
Authors: Zélé Flore , Altıntaş Mustafa , Santos Inês , Cakmak Ibrahim , Magalhães Sara 
Published: March 2020

AbstractMany studies have revealed the ability of the endosymbiotic bacterium Wolbachia to protect its arthropod hosts against diverse pathogens. However, as Wolbachia may also increase the susceptibility of its host to infection, predicting the outcome of a particular Wolbachia‐host–pathogen interaction remains elusive. Yet, understanding such interactions and their eco‐evolutionary consequences is crucial for disease and pest control strategies. Moreover, how natural Wolbachia infections affect artificially introduced pathogens for biocontrol has never been studied. Tetranychus urticae spider mites are herbivorous crop pests, causing severe damage on numerous economically important crops. Due to the rapid evolution of pesticide resistance, biological control strategies using entomopathogenic fungi are being developed. However, although spider mites are infected with various Wolbachia strains worldwide, whether this endosymbiont protects them from fungi is as yet unknown. Here, we compared the survival of two populations, treated with antibiotics or naturally harboring different Wolbachia strains, after exposure to the fungal biocontrol agents Metarhizium brunneum and Beauveria bassiana. To control for potential effects of the bacterial community of spider mites, we also compared the susceptibility of two populations naturally uninfected by Wolbachia, treated with antibiotics or not. In one population, Wolbachia‐infected mites had a better survival than uninfected ones in absence of fungi but not in their presence, whereas in the other population Wolbachia increased the mortality induced by B. bassiana. In one naturally Wolbachia‐uninfected population, the antibiotic treatment increased the susceptibility of spider mites to M. brunneum, but it had no effect in the other treatments. These results suggest that natural Wolbachia infections may not hamper and may even improve the success of biological control using entomopathogenic fungi. However, they also draw caution on the generalization of such effects, given the complexity of within‐host–pathogens interaction and the potential eco‐evolutionary consequences of the use of biocontrol agents for Wolbachia‐host associations.
Variation in the ontogenetic allometry of horn length in bovids along a body mass continuum
Authors: Tidière Morgane , Gaillard Jean‐Michel , Garel Mathieu , Lemaître Jean‐François , Toïgo Carole , Pélabon Christophe 
Published: March 2020

AbstractAllometric relationships describe the proportional covariation between morphological, physiological, or life‐history traits and the size of the organisms. Evolutionary allometries estimated among species are expected to result from species differences in ontogenetic allometry, but it remains uncertain whether ontogenetic allometric parameters and particularly the ontogenetic slope can evolve. In bovids, the nonlinear evolutionary allometry between horn length and body mass in males suggests systematic changes in ontogenetic allometry with increasing species body mass. To test this hypothesis, we estimated ontogenetic allometry between horn length and body mass in males and females of 19 bovid species ranging from ca. 5 to 700 kg. Ontogenetic allometry changed systematically with species body mass from steep ontogenetic allometries over a short period of horn growth in small species to shallow allometry with the growth period of horns matching the period of body mass increase in the largest species. Intermediate species displayed steep allometry over long period of horn growth. Females tended to display shallower ontogenetic allometry with longer horn growth compared to males, but these differences were weak and highly variable. These findings show that ontogenetic allometric slope evolved across species possibly as a response to size‐related changes in the selection pressures acting on horn length and body mass.
A new native plant in the neighborhood: effects on plant–pollinator networks, pollination, and plant reproductive success
Authors: Hernández‐Castellano Carlos , Rodrigo Anselm , Gómez José María , Stefanescu Constantí , Calleja Juan Antonio , Reverté Sara , Bosch Jordi 
Published: March 2020

AbstractEcological communities are dynamic entities subjected to extinction/colonization events. Because species are connected through complex interaction networks, the arrival of a new species is likely to affect various species across the community, as observed in plant biological invasions. However, plant invasions usually represent extreme scenarios in which the community is strongly dominated by the alien species, confounding the effects of a change in species composition with a massive increase in floral resource availability. Our study addresses changes in plant community composition involving native species, a common phenomenon under the current climate change scenario in which plants are modifying their distribution ranges. We experimentally manipulated patches of a natural scrubland community by introducing a native plant (henceforth colonizing plant). To avoid introducing a disproportionate amount of floral resources we adjusted the number of flowers of the colonizing plant to the amount of floral resources locally available in each patch. We had two objectives: (1) to analyse the effects of the arrival of a new plant on the pollinator community, the rearrangement of plant–pollinator interactions and the structure of the plant–pollinator network; (2) to evaluate potential consequences for pollination and the reproductive success of resident plant species. The colonizing plant acted as a magnet species, attracting bumble bees and facilitating interactions to other plants through spill‐over. The introduction of the colonizing plant also affected the structure of plant–pollinator networks (colonized networks were more generalized and more nested than control networks) and modified the arrangement of plant and pollinator species into modules. Ultimately, these changes resulted in higher heterospecific (but not conspecific) pollen deposition and had contrasting effects on the reproductive success of two resident plant species (higher fruit set and lower seed set, respectively). Our study shows that relationships between plants and pollinators are rapidly rearranged in response to novel situations (even when the new plant is not overly dominant), with important functional consequences on pollination and plant reproductive success. Our study establishes a link between network structure and pollination and plant reproductive success, which may be mediated by differences among pollinator species in foraging behavior.
Emerging dynamics of public participation in climate governance: A case study of solar energy application in Shenzhen, China
Authors: Huang Ping , Castán Broto Vanesa , Westman Linda Katrin 
Published: March 2020

AbstractClimate governance scholars have recognized the role of public participation in improving the outcomes of climate action. Nevertheless, increasing advocacy of environmental authoritarianism in the narratives of climate governance questions the need for and legitimacy of public participation. This study uncovers the emerging dynamics of climate participation in Chinese communities through a case of the implementation of solar energy. Our research challenges the general impression of nonparticipation in climate governance in China and argues that participation is taking a less visible form that we call “defensive participation.” Defensive participation occurs when communities mobilize to defend their interests. Just as other forms of public participation, defensive participation can play important roles in improving policy outcomes and accountability. More nuanced theoretical and empirical accounts of public participation in climate governance will improve current understandings of climate governance in China.
Thermophysical analysis of three‐dimensional magnetohydrodynamic flow of a tangent hyperbolic nanofluid
Authors: Oyelakin Ibukun S. , Lalramneihmawii PC , Mondal Sabyasachi , Nandy Samir K. , Sibanda Precious 
Published: March 2020

AbstractIn this article, we use the Buongiorno model to study the three‐dimensional tangent hyperbolic nanofluid flow over a stretched sheet. The study investigates the impact of velocity slip on the flow and heat transfer features in a tangent hyperbolic nanofluid. For a better fit with experimental observations. We assume that the nanoparticle mass flux at the boundary is zero as opposed to a prescribed concentration at the surface. Using appropriate transformations, we reduce the partial differential equations that describe the momentum, energy, and concentration transport to ordinary differential equations. Numerical solutions of the equations are obtained using the spectral method. Graphical illustration of the physical influence of various parameters on the flow features, the skin friction coefficient, and the local Nusselt number is given. The results indicate, that particle Brownian motion has a negligible impact on the rate of heat transfer. The impact of the modified Weissenberg number, a measure of the ratio of elastic to viscous forces, causes a reduction in the fluid velocity. The results are shown to be good agreement with those in related studies in the literature.
The IKKβ‐USP30‐ACLY Axis Controls Lipogenesis and Tumorigenesis
Authors: Gu Li , Zhu Yahui , Lin Xi , Lu Bingjun , Zhou Xinyi , Zhou Feng , Zhao Qiu , Prochownik Edward V. , Li Youjun 
Published: March 2020

Background and Aims
Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death that develops as a consequence of obesity, cirrhosis, and chronic hepatitis. However, the pathways along which these changes occur remain incompletely understood.

Approach and Results
In this study, we show that the deubiquitinase USP30 is abundant in HCCs that arise in mice maintained on high‐fat diets. IKKβ phosphorylated and stabilized USP30, which promoted USP30 to deubiquitinate ATP citrate lyase (ACLY) and fatty acid synthase (FASN). IKKβ also directly phosphorylated ACLY and facilitated the interaction between USP30 and ACLY and the latter’s deubiquitination. In HCCs arising in DEN/CCl4‐treated mice, USP30 deletion attenuated lipogenesis, inflammation, and tumorigenesis regardless of diet. The combination of ACLY inhibitor and programmed death ligand 1 antibody largely suppressed chemical‐induced hepatocarcinogenesis. The IKKβ‐USP30‐ACLY axis was also found to be up‐regulated in human HCCs.

Conclusions
This study identifies an IKKβ‐USP30‐ACLY axis that plays an essential and wide‐spread role in tumor metabolism and may be a potential therapeutic target in HCC.
Human mast cells exhibit an individualized pattern of antimicrobial responses
Authors: Garcia‐Rodriguez Karen M. , Bahri Rajia , Sattentau Clara , Roberts Ian S. , Goenka Anu , Bulfone‐Paus Silvia 
Published: March 2020

AbstractIntroductionMast cells (MCs) are tissue‐resident immune cells implicated in antibacterial responses. These include chemokine secretion, degranulation, and the release of mast cell‐extracellular traps, which are primarily dependent on reactive oxygen species (ROS) production. Our study investigated whether human mast cells (hMCs) develop individual response patterns to bacteria located at different tissue sites: Escherichia coli (gut commensal), Listeria monocytogenes (foodborne intracellular pathogen), Staphylococcus aureus (skin commensal and opportunistic pathogen), and Streptococcus pneumoniae (upper respiratory tract commensal and lung pathogen).MethodsAfter live bacteria exposure, hMCs were analyzed by a combined flow cytometry assay for degranulation, ROS production, DNA externalization, and for β‐hexosaminidase, chemokine, and prostaglandin release.ResultsL. monocytogenes induced hMC degranulation, IL‐8 and MCP‐1 release coupled with DNA externalization in a novel hMC ROS independent manner. In contrast, S. pneumoniae caused ROS production without DNA release and degranulation. E. coli induced low levels of hMC degranulation combined with interleukin 8 and MCP‐1 secretion and in the absence of ROS and DNA externalization. Finally, S. aureus induced hMCs prostaglandin D2 release and DNA release selectively. Our findings demonstrate a novel hMC phenomenon of DNA externalization independent of ROS production. We also showed that ROS production, degranulation, DNA externalization, and mediator secretion occur as independent immune reactions in hMCs upon bacterial encounter and that hMCs contribute to bacterial clearance.ConclusionsThus, hMCs exhibit a highly individualized pattern of immune response possibly to meet tissue requirements and regulate bacteria coexistence vs defense.
Burden of asthma exacerbations and health care utilization in pediatric patients with asthma in the US and England
Authors: Gokhale Mugdha , Hattori Takako , Evitt Lee , Lenney Warren , Nordstrom Beth , Collins Jenna , Schultze Anna , Van Dyke Melissa K. 
Published: March 2020

AbstractBackgroundData on asthma burden in pediatric patients are limited; this real‐world study investigated exacerbation frequency and health care resource utilization (HCRU) in pediatric asthma patients from the US and England.MethodsData from pediatric patients (aged 6‐17 years) in the Optum claims database (US) or Clinical Practice Research Datalink with linkage to Hospital Episode Statistics (England) were analyzed. Patients were categorized into four hierarchical groups: treated asthma (patients with ≥1 baseline asthma medication), severe asthma (plus Global Initiative for Asthma Step 4/5), severe refractory asthma ([SRA] plus ≥2 baseline severe asthma exacerbations), and eosinophilic SRA (SRA plus blood eosinophil count ≥150 cells/µL). Exacerbation frequency and HCRU during the 12 months postindex were described.ResultsOf 151 549 treated asthma patients in the US, 18 086 had severe asthma, 2099 SRA, and 109 eosinophilic SRA. There were 32 893 treated asthma patients in England, of whom 2711 had severe asthma, 265 SRA, and 8 eosinophilic SRA. In the 12 months postindex, ≥1 exacerbation occurred in 12.4% and 10.8% of patients with severe asthma, and 32.6% and 42.6% with SRA in the US and England, respectively. The proportions of patients with ≥1 asthma hospitalization in the 30 days after the first asthma exacerbation were 2.7% and 4.4% (treated), 3.5% and 8.2% (severe asthma), and 6.0% and 16.8% (SRA) in the US and England, respectively.ConclusionThis study provides insights into current asthma management practices in the US and England and indicates that some patients with severe disease have an unmet need for effective management.
Image analysis by fast improved radial harmonic‐Fourier moments algorithm
Authors: He Bing , Cui Jiangtao , Peng Yanguo , Yang Tengfei 
Published: March 2020

AbstractRadial harmonic‐Fourier moments (RHFMs) are popular for image reconstruction and invariant pattern recognition due to their properties of translation, scaling and rotation invariant. RHFMs possess lower computation complexity as compared to Zernike moments and Bessel‐Fourier moments. However, they always suffer from discontinuity, numerical instability near the center of image, and reconstruction error, especially have a rise for higher order of moments. In this paper, an improvement of radial harmonic‐Fourier moments (IRHFMs) is proposed for effectively avoiding the above‐mentioned problems.In this paper, a 2D fast Fourier transform algorithm also is applied to the image matrix to obtain the IRHFMs. Simulation experimental results demonstrate the proposed IRHFMs perform better than traditional RHFMs and other classic orthogonal moments including the latest image moments, for example, polar harmonic Fourier moments in terms of the image reconstruction capability and rotation invariant recognition accuracy in noise‐free and noisy conditions.
Reviewing and understanding the stability mechanism of halide perovskite solar cells
Authors: Zhang Cai‐Xin , Shen Tao , Guo Dan , Tang Li‐Ming , Yang Kaike , Deng Hui‐Xiong 
Published: March 2020

AbstractFinding sustainable and renewable energy to replace traditional fossil fuel is critical for reducing greenhouse gas emission and avoiding environment pollution. Solar cells that convert energy of sunlight into electricity offer a viable route for solving this issue. At present, halide perovskites are the most potential candidate materials for solar cell with considerable power conversion efficiency, whereas their stability remains a challenge. In this work, we summarize four different key factors that influence the stability of halide perovskites: (a) effect of environmental moisture on the degradation of halide perovskites. The performance of halide perovskite solar cells is reduced due to hydrated crystal hinders the diffusion of photo‐generated carriers, which can be solved by materials encapsulation technique; (b) photo‐induced instability. Through uncovering the underlying physical mechanism, we note that materials engineering or novel device structure can extend the working life of halide perovskites under continuous light exposure; (c) thermal stability. Halide perovskites are rapidly degraded into PbI2 and volatile substances as heating due to lower formation energy, whereas hybrid perovskite is little changed; (d) electric field effect in the degradation of halide perovskites. The electric field impacts significantly on the carrier separation, changes direction of photo‐induced currents and generates switchable photovoltaic effect. For each key factor, we have shown in detail the underlying physical mechanisms and discussed the strategies to overcome this stability difficulty. We expect this review from both theoretical and experimental points of view can be beneficial for development of perovskite solar cell materials and promotes practical applications.image
Full band Monte Carlo simulation of AlInAsSb digital alloys
Authors: Zheng Jiyuan , Ahmed Sheikh Z. , Yuan Yuan , Jones Andrew , Tan Yaohua , Rockwell Ann K. , March Stephen D. , Bank Seth R. , Ghosh Avik W. , Campbell Joe C. 
Published: March 2020

AbstractAvalanche photodiodes fabricated from AlInAsSb grown as a digital alloy exhibit low excess noise. In this article, we investigate the band structure‐related mechanisms that influence impact ionization. Band‐structures calculated using an empirical tight‐binding method and Monte Carlo simulations reveal that the mini‐gaps in the conduction band do not inhibit electron impact ionization. Good agreement between the full band Monte Carlo simulations and measured noise characteristics is demonstrated.image
How to choose a point‐of‐care testing for troponin
Authors: Lin Ya‐hui , Zhang Yang , Liu Yu‐tao , Cui Kai , Kang Jin‐suo , Zhou Zhou 
Published: March 2020

AbstractBackgroundPoint‐of‐care (POC) cTn assays are needed when the central laboratory is unable to provide timely results to the emergency department. Many POC devices are available. The prospect of choosing them is daunting. In order to provide a quick decision‐making reference for POC cTn device selection comparing them to the central laboratory, seven POC devices commonly employed by emergency department were evaluated.MethodsFirstly, we reviewed all devices package inserts. Secondly, we evaluated several POC cTn assays for imprecision, linearity, and correlation with central laboratory assays according to CLSI EP protocols. The linear regression analyses were performed only for the detectable concentrations. Five cTnI devices (Alere Triage, BioMerieux Vidas, Mitsubishi Pathfast, ReLIA TZ‐301, and Radiometer AQT90) were evaluated against a contemporary cTnI assay (Beckman Access II Accu TnI). Two cTnT assays (Radiometer AQT90 and Roche Cobas h232) were compared to a high‐sensitivity (hs) cTnT method (Roche Cobas e601).ResultsFor cTn levels around the 99th percentile upper reference limits (URLs) of the comparator assays, imprecision could not be assessed for the Alere, BioMerieux, and Cobas h232 as they gave undetectable readings due to a lack of assay sensitivity. Imprecision (CV) was unacceptably high for the ReLIA (33.3%). On account of this precision metric, these four assays were deemed unsuitable. Regression analyses showed acceptable linearity for all the POC devices. The correlation coefficients for ReLIA, BioMerieux, Cobas h232, and Radiometer cTnT were >0.95. Unlike the cTnT devices, the cTnI assays employ different capture and detection antibodies leading to non‐commutable results. The POC cTn results were concordant with their comparator—Radiometer cTnT 90%, Pathfast cTnI 85%, and Radiometer cTnI 75%.ConclusionOur study provides the procedure and essential data to guide selection of a POC cTn device. Of the point‐of‐care devices, methods evaluated Radiometer AQT90 (cTnI and cTnT) and Pathfast might be considered.
Mentalizing stigma: Reflective functioning as a protective factor against depression and anxiety in transgender and gender‐nonconforming people
Authors: Scandurra Cristiano , Dolce Pasquale , Vitelli Roberto , Esposito Giovanna , Testa Rylan J. , Balsam Kimberly F. , Bochicchio Vincenzo 
Published: March 2020

AbstractObjectiveThe current study examined the role of internalized transphobia (IT) as a mediator between gender‐related rejection and mental health, and reflective functioning (or mentalization) as a resilience factor moderating the relationship between both rejection and IT with mental health.MethodThis online study included 203 Italian transgender and gender‐nonconforming (TGNC) individuals ranged in age from 18 to 66 years old (M = 30.70; standard deviation = 10.79). Moderated‐mediation analysis was performed using a structural equation modeling approach.ResultsBoth rejection and IT were positively associated with mental health, and IT mediated the relationship between rejection and mental health. Mentalization moderated the relationship between rejection and IT with mental health. The indirect effect of rejection on mental health through IT was moderated by mentalization.ConclusionsFindings highlight psychological paths that may inform individual‐ and group‐level mentalization‐based interventions to reduce minority stress in TGNC individuals.