bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Inhibition of Bovine Hepatic Cytochrome P450 by 43 Commercial Bovine Medicines Using a Combination ofIn VitroAssays and Pharmacokinetic Data from the Literature
Authors: Hu Steven X. , Mazur Chase A. , Feenstra Kenneth L. 
Published: November 2019

Background:There has been a lack of information about the inhibition of bovine medicines on bovine hepatic CYP450 at their commercial doses and dosing routes.Objective:The aim of this work was to assess the inhibition of 43 bovine medicines on bovine hepatic CYP450 using a combination of in vitro assay and Cmax values from pharmacokinetic studies with their commercial doses and dosing routes in the literature.Methods:Those drugs were first evaluated through a single point inhibitory assay at 3 μM in bovine liver microsomes for six specific CYP450 metabolisms, phenacetin o-deethylation, coumarin 7- hydroxylation, tolbutamide 4-hydroxylation, bufuralol 1-hydroxylation, chlorzoxazone 6-hydroxylation and midazolam 1’-hydroxylation. When the inhibition was greater than 20% in the assay, IC50 values were then determined. The potential in vivo bovine hepatic CYP450 inhibition by those drugs was assessed using a combination of the IC50 values and in vivo Cmax values from pharmacokinetic studies at their commercial doses and administration routes in the literature.Results:Fifteen bovine medicines or metabolites showed in vitro inhibition on one or more bovine hepatic CYP450 metabolisms with different IC50 values. Desfuroylceftiour (active metabolite of ceftiofur), nitroxinil and flunixin have the potential to inhibit one of the bovine hepatic CYP450 isoforms in vivo at their commercial doses and administration routes. The rest of the bovine medicines had low risks of in vivo bovine hepatic CYP450 inhibition.Conclusion:This combination of in vitro assay and in vivo Cmax data provides a good approach to assess the inhibition of bovine medicines on bovine hepatic CYP450.
Empirical Models for Estimating Tropospheric Radio Refractivity Over Osogbo, Nigeria
Authors: Akpootu D. O. , Rabiu A. M. 
Published: November 2019

Background:Estimation of tropospheric radio refractivity is significant in the planning and design of terrestrial communication links.Methods:In this study, the monthly average daily atmospheric pressure, relative humidity and temperature data obtained from the National Aeronautics and Space Administration (NASA) during the period of twenty two years (July 1983 - June 2005) for Osogbo (Latitude 7.470N, Longitude 4.290E, and 302.0 m above sea level) were used to estimate the monthly tropospheric radio refractivity. The monthly average daily global solar radiation with other meteorological parameters was used to developed one, two, three and four variable correlation(s) tropospheric radio refractivity models for the location. The accuracy of the proposed models are validated using statistical indicator of coefficient of determination (R2), Mean Bias Error (MBE), Root Mean Square Error (RMSE), Mean Percentage Error (MPE), Nash - Sutcliffe Equation (NSE) and Index of Agreement (IA).Results:In each case one empirical model was recommended based on their exceptional performances after ranking, except for the two variation correlations with two empirical models. The recommended models were further subjected to ranking from which the three variable correlations model that relates the radio refractivity with the absolute temperature, relative humidity and global solar radiation was found more suitable for estimating tropospheric radio refractivity for Osogbo with R2= 100.0%, MBE = -0.2913 N-units, RMSE = 0.3869 N-units, MPE = 0.0811%, NSE = 99.9999% and IA = 100.00%.Conclusion:The newly developed recommended models (Equations 16c, 17d, 17f, 18d and 19) can be used for estimating daily and monthly values of tropospheric radio refractivity with higher accuracy and has good compliance to highly varying climatic conditions for Osogbo and regions of similar climatic information.
Anticancer Potential of Michelia champaca Linn. Bark Against Ehrlich Ascites Carcinoma (EAC) Cells in Swiss Albino Mice
Authors: Yesmin Ruksana , Das Plabon Kumar , Belal Hazrat , Aktar Suraiya , Siddika Mst. Ayesha , Asha Saharia Yeasmin , Habib Farjana , Rakib Md. Abdur , Islam Farhadul 
Published: November 2019

Background:
Adverse side effects of currently available therapies against cancer, leads
scientists to find effective compounds from natural sources.

Objective:
In the present study, stem-bark of Mycelia champaca is subjected to evaluate its antiproliferative
effect against Ehrlich Ascites Carcinoma (EAC) cells. To date, the anti-proliferative effects
of M. champaca bark extract against EAC cell line has not been reported elsewhere. Therefore,
we intended to investigate the anti-proliferative potential of M. champaca bark extract against EAC
cells in vivo.

Methods:
In vivo anticancer activity was evaluated against EAC cells bearing Swiss albino mice by
monitoring parameters such as tumor cell proliferation, tumor weight measurement, and survival
time, etc. The mechanism of EAC killing was examined by observation of cell morphology and
analysis the expression of certain cancer-related genes. In vitro antioxidant potentiality was determined
in terms of several common antioxidant assays. In addition, total phenolic and flavonoids
contents were measured to ensure the presence of phytochemicals.

Results:
M. champaca bark extract showed strong antioxidant activities which were found to be
strongly correlated (P<0.001) with phenolics and flavonoids contents. Furthermore, it was found that
bark extract decreased tumor cell proliferation (77.46%; P<0.01), tumor weight (42.13%; P<0.001)
and increased life span of tumor-bearing mice (71.97%; P<0.01) at the dose of 250mg/kg (intraperitoneal;
i.p.). M. champaca bark also altered the depleted hematological parameters such as red blood
cell, white blood cell, hemoglobin (Hb%) towards normal in tumor bearing mice. In addition, upregulation
of p53, Bax and downregulation of Bcl-2 followed by treatment indicated M. champaca bark
could induce apoptosis of EAC cells.

Conclusion:
These results indicated that MEMCB possesses significant cytotoxic activities against
EAC cells and has a strong in vitro antioxidant capacity. Therefore, the bark of M. champaca could
be considered as a potential resource of anti-cancer agents, which might be used to formulate effective
anticancer drugs.
ESCHERICHIA COLI RESISTEN ANTIBIOTIK ASAL AIR KERAN DI KAMPUS ISTN
Authors: Hamida Fathin , Aliya Lisana Sidqi , Syafriana Vilya , Pratiwi Della 
Published: November 2019

Resistensi antibiotik menjadi masalah global yang menyebar luas di dunia. Lingkungan merupakan jalur transmisi dan menyebabkan resistensi antibiotik. Hal itu dapat disebabkan oleh buruknya infrastruktur limbah air dan kontaminasi fekal. Kontaminasi air berpengaruh buruk bagi kesehatan manusia. Kampus ISTN memiliki pipa saluran air keran yang jarak berdekatan dengan pipa septic tank, jarak antara pipa air keran dengan pipa septic tank berkisar ≤ 11 meter. Kontaminasi air oleh Escherichia coli menjadi factor penurunan kualitas air. Penelitian ini bertujuan mengisolasi E. coli dari pipa air keran kampus ISTN dan mendeteksi resistensinya terhadap antibiotik. Empat isolate E. coli telah diisolasi menggunakan media Lactose Broth dan Chromogenic Coliform Agar. Empat isolat E. coli telah diidentifikasi secara biokimiawi. Empat isolate E. coli diuji sensitivitasnya terhadap antibiotik amoksisilin, tetrasiklin, kloramfenikol, dan siprofloksasin menggunakan metode difusi cakram. Sensitivitas antibiotik diinterpresikan berdasarkan standar CLSI (Clinical and Laboratory Standard Institute). Hasil menunjukkan bahwa isolat 1A, 2A, 3A, dan 4A resisten terhadap amoksisilin, dan isolat 1A bersifat intermediat.
Analisis Faktor-Faktor Yang Mempengaruhi Kualitas Laporan Keuangan Pemerintah Daerah (Studi Pada Pemerintah Kabupaten Pasaman Barat)
Authors: Mulia Rizki Afri 
Published: November 2019

Bentuk laporan pertanggungjawaban atas pengelolaan keuangan daerah selama satu tahun anggaran adalah dalam bentuk Laporan Keuangan Pemerintah Daerah (LKPD). Laporan keuangan pemerintah daerah harus mengikuti Standar Akuntansi Pemerintahan sesuai Peraturan Pemerintah No.24 Tahun 2005. Penelitian ini bertujuan untuk memberikan bukti bahwa : 1) Untuk memberikan bukti empiris dan menganalisis pengaruh kompetensi Sumber Daya Manusia (SDM) terhadap kualitas laporan keuangan pemerintah daerah Pasaman Barat secara signifikan. 2) Untuk memberikan bukti empiris dan menganalisis pengaruh Sistem Pengendalian Intern terhadap kualitas laporan keuangan pemerintah daerah Pasaman Barat secara signifikan.Pengumpulan data dilakukan dengan metode survei dengan kuesioner. Teknik analisa data yang digunakan dalam penelitian ini adalah analisis deskriptif dan kuantitatif. Data yang dikumpulkan merupakan data primer dan sekunder yang dapat digolongkan sebagai variabel bebas dan variabel terikat. Kompetensi SDM dan Sistem Pengendalian Intern (variabel pengaruh), dan Kualitas Laporan Keuangan Pemerintah Daerah Kabupaten Pasaman Barat (variabel terpengaruh). Pengujian hipotesis dalam penelitian ini menggunakan uji regresi linier berganda.Berdasarkan hasil penelitian diketahui bahwa : 1) Terdapat pengaruh positif dan signifikan antara Kompetensi SDM terhadap Kualitas Laporan Keuangan Pemerintah Daerah Kabupaten Pasaman Barat didapat Thitung dimana 3,249 dengan signifikansi 0,002 dimana 0,002< 0,05. 2) Terdapat pengaruh positif dan signifikan antara Sistem Pengendalian Inter terhadap dan Laporan Keuangan Pemerintah Daerah Kabupaten Pasaman Barat didapat Thitung dimana 4,524 dengan signifikansi 0,000<0,05.
ANALISIS TINGKAT PEMAHAMAN MAHASISWA AKUNTANSI TERHADAP KONSEP DASAR AKUNTANSI SETELAH PEMBERLAKUAN IFRS
Authors: Novi Elisa 
Published: November 2019

Tujuan penelitian ini adalah untuk melihat tingkat pemahaman mahasiswa yang beradal dari SMK jurusan Akuntansi, SMU jurusan IPS dan MA jurusan IPS tentang konsep dasar akuntansi setelah pemberlakuan IFRS dengan menggunakan variabel Aset, Kewajiban dan Ekuitas. Tehnik pengumpulan data menggunakan kuesioner, dengan menggunakan sampel sebanyak 90 orang mahasiswa Akuntansi S1 Universitas Riau dan UIN Suska Riau yang aktif pada smester III tahun akade mik 2012/2013 dan telah lulus mata kuliah Pengantar Akuntansi 1 dan 2Penelitian ini menggunakan uji beda Kruskal Wallis. D ari tiga variabel yangdijadikan pengukuran perbedaan tingkat pemahaman mahasiswa terhadap konsepdasar akuntansi yaitu aset, kewajiban dan ekuitas tidak terdapat perbedaanpemahaman mahasiswa terhadap konsep dasar akuntansi setelah pemberlakuan IFRS.Dari nilai mean rank ketiga variabel maka terlihat bahwa mahasiswa yang berasal dari Madrasah Aliyah lebih memahami konsep dasar akuntansi dibandingkan mahasiswa yang berasal dari SMK dan mahasiswa yang berasal dari SMA
ANALISIS PERILAKU WORD OF MOUTH WISATAWAN TAMAN REKREASI KOTA PEKANBARU: TINJAUAN DARI ASPEK SERVICE QUALITY DAN COSTUMER SATISFACTION
Authors: Lahamid Qomariah 
Published: November 2019

Penelitian ini membahas hubungan antara kualitas pelayanan, kepuasandan word of mouth (WOM) wisatawan tamanrekreasi kota Pekanbaru. Adapun tujuan penelitian ini yaitu 1) Untuk mengetahui service quality dan costumer satisfactionwisatawan taman rekreasi kota Pekanbaru. 2) Untuk mengetahui pengaruh yang signifikan antara service quality dengan perilaku WOM wisatawan tamanrekreasi kota Pekanbaru. 3) Untuk mengetahui pengaruh yang signifikan antara costumer satisfaction dengan perilaku WOM wisatawan tamanrekreasi kota Pekanbaru. 4) Untuk mengetahui pengaruh yang signifikan antara service quality dengan costumer satisfaction wisatawan taman rekreasi kota Pekanbaru.Sampel dalam penelitian ini sebanyak 248 responden yang diambil dengan teknik purposive samplingdengan kriteria telah pernah mengunjungi minimal dua taman rekreasi yang ada di kota Pekanbaru. Penelitian ini menggunakan analisisStructural Equation Modelling (SEM) dengan aplikasi software Analysis Moment of Structure (AMOS) dan Special Package for Statistis Science (SPSS).Hasil penelitian menunjukkan bahwa : 1) Service qualityberpengaruhsignifikan terhadapperilaku WOM wisatawan taman rekreasi kota Pekanbaru. 2) Costumer satisfactionberpengaruh signifikan terhadap perilaku WOM wisatawan taman rekreasi kota Pekanbaru. 3) Service qualityberpengaruh signifikan terhadapcostumer satisfaction wisatawan taman rekreasi kota Pekanbaru.
PENGARUH STRUKTUR MODAL, AGENCY COST, DAN DIVIDEND PAYOUT RATIO TERHADAP KINERJA PERUSAHAAN YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2008-2012
Authors: Ayu Eka Nuraini Rachmawati, 
Published: November 2019

Penelitian ini bertujuan untuk menguji pengaruh secara silmutan dan parsial variabel struktur modal, agency cost dan dividend payout ratio terhadap kinerja perusahaan yang terdaftar di Bursa Efek Indonesia. Penentuan sampel berdasarkan metode purposive sampling, sampel diambil sebanyak 10 perusahaan pada tahun 2008-2012. Analisis data menggunakan analisisregresi berganda. Hasil penelitian menunjukkan bahwa struktur modal berpengaruh positif dan signifikan terhadap kinerja perusahaan dan agency cost berpengaruh negatif dan signifikan terhadap kinerja perusahaan. Namun dividend payout ratio tidak mempunyai pengaruh terhadap kinerja perusahaan. Secara simultan struktur modal, agency cost dan dividend payout ratiomempunyai pengaruh signifikan terhadap Kinerja Perusahaan yang terdaftar di Bursa Efek Indonesia.
MEMAHAMI PRAKTEK BAGI-HASIL KEB MASYARAKAT KAMPAR RIAU (Sebuah Pendekatan Etnografi)
Authors: Eko Ganis Sukoharsono Iwan Triyuwono, 
Published: November 2019

This study is aimed to grasp the meaning of a rubber revenue-sharingfrom the point of view of people who understand the revenue-sharing practice inKampar community through participatory observation. Additionally, it is aimed to deepen the understanding of revenue-sharing practice in Kampar Riau community. This study uses a qualitative method with Etnography approach. Data were collected through participation observation and open in-depth interviews. The data were analyzed using Spradley model (1997), with includes domainanalysis, taxonomic analysis, componential analysis and cultural analysis. Theresults of this study were that gotah revenue-sharing is revenue-sharingcontaining the value of KESOJUKAN (Keadilan/Justice, Kesosialan/Socialism,Kejujuran/Honesty and Keamanahan/Trustworthiness) in which Gotah revenue-sharing is a traditional custom practiced by generation and based on Islamic values.
PENGARUH KUALITAS PELAYANAN JASA BANK TERHADAP PENINGKATAN JUMLAH KEUNTUNGAN BANK SWASTA ”XYZ”CABANG PEKANBARU
Authors: Gatot Wijayanto Syahdanur, 
Published: November 2019

Penelitian ini bertujuan untuk menganalisis pengaruh faktor kualitas pelayanan jasa bank yang terdiri dari faktor Tangible, Reliablity, Responsiveness, Assurance, danEmphaty terhadap peningkatan jumlah keuntungan Bank Swasta “XYZ” Cabang Pekanbaru, baik secara simultan maupun parsial dan untuk mengetahui faktor kualitas pelayanan jasa bank yang mempunyai pengaruh paling dominan terhadap peningkatan jumlah keuntungan Bank Swasta “XYZ” Cabang Pekanbaru. Dengan mengambil sampel sebanyak 100 responden dengan rumus Slovin dari keseluruhan nasabah yang menabung di Bank Swasta “XYZ” Cabang Pekanbaru sebanyak 25.422 orang sebagai populasinya dan analisis datanya menggunakan Analisis Jalur (Path Analisis).Dari hasil pengujian statistik menunjukkan bahwa aspek dimensi Responsiveness yang merupakan nilai pelayanan jasa bank berpengaruh relatif besar terhadap peningkatan jumlah keuntungan Bank Swasta “XYZ” Cabang Pekanbaru. Agar kualitas dan nilai palayanan Bank Swasta “XYZ” Cabang Pekanbaru mampu memberikan konstribusi yang lebih tinggi lagi terhadap peningkatan jumlah keuntungan Bank Swasta “XYZ” Cabang Pekanbaru, maka selayaknya Bank Swasta “XYZ” Cabang Pekanbaru mempertimbangkan; masalah perluasan jaringan dan prasarana pendukung, penyempurnaan sistim dan prosedur yang didukung oleh sistim komputerisasi, meningkatkan kemudahan dalam proses pembukaan, penyetoran dan penarikan dana, adanya kepedulian terhadap para nasabah agar tercipta brand loyalty. Di samping itu, agar nilai kualitas pelayanan yang dilakukan oleh Bank Swasta “XYZ” Cabang Pekanbaru tetap baik sehingga dapat meningkatkan keuntungan bank, maka perlunya meningkatkan keindahan inrterior dan eksterior yang khas tempat melakukan pelayanan bagi para nasabah.
Breeding and Performance Potential of Puławska Pigs – A Review
Authors: Babicz Marek , Hałabis Marcin , Skałecki Piotr , Domaradzki Piotr , Litwińczuk Anna , Kropiwiec-Domańska Kinga , Łukasik Magdalena 
Published: November 2019

Abstract
The aim of the study was to discuss breeding of pigs of the Puławska breed, which is included in a Genetic Resources Conservation Programme, and to analyse performance parameters that are useful in domestic pig production. The Puławska breed is the oldest native breed of pig in Poland. Since 1996 it has been protected by a genetic resources conservation programme, owing to breeding traditions and the production traits characteristic of the breed. The use value of these pigs is currently at the level of maternal breeds: number of live piglets born per litter – 10.54; number of piglets reared per litter – 9.37; daily weight gains – 569 g for breeding boars and 562 g for breeding gilts; meat content – 54.6% for breeding boars and 54.9% for breeding gilts. An important element in favour of the use of this breed in domestic production of fresh pork and pork products is its meat quality parameters. The mean values for physical traits (WHC 22.42%, pH45 6.47, pH24 5.63) and chemical parameters (protein 22.70%, fat 2.65%) are characteristic of meat of normal quality. The Puławska breed can be used to produce high-quality fresh meat and meat products, including traditional and regional ones. Puławska pigs are bred and reared according to the principles of sustainable agriculture, which reduces the negative impact of pig production on the natural environment.
Age and growth of common bream, Abramis brama (L.), caught at Hammam Debagh Reservoir (Guelma, northeast Algeria)
Authors: Guettaf Mohamed , Rachedi Mounira , Gueroui Yassine , Bousbia Aissam , Chelaghmia Mohamed Amine , Maoui Ammar 
Published: November 2019

Abstract
This study was conducted in Hammam Debagh Reservoir located in northeastern Algeria, which was first the subject of fish farming tests in 2001. The species tested included Chinese carp, royal carp, common carp, pikeperch, and common bream. The present work aimed to determine the age and growth of one of the most frequently caught species in the reservoir, common bream, Abramis brama. This information is essential to the knowledge of fish biology, and thereby to solving many of the problems of fish research and development. A sample of 100 common bream, A. brama, was caught with gillnets over a period of six months from December 2017 to May 2018. The results obtained fit well with the growth model and were similar to those published regarding other environments. Scales from a sample of 50 fish were read under an optical microscope, which permitted identifying five age groups. The value of the overall sex ratio (4.88) revealed a strong imbalance in favor of males throughout the study period. The relationship linking length-weight is of the minor allometry type with b < 3.
Factors limiting successful reproduction in wild silver carp, Hypophthalmichtys molitrix, in Kherrata Reservoir, Algeria
Authors: Sadouni Soraya , Iguer-Ouada Mokrane 
Published: November 2019

Abstract
Silver carp, Hypophthalmichtys molitrix (Cyprinidae), is the most important freshwater fish in Algerian aquaculture. No natural spawning is observed in Algerian water bodies. This study was conducted with the aim of investigating silver carp reproduction in the wild in Algeria. This investigation can contribute tools to facilitate successful artificial reproduction. Macroscopic and histological analysis of the gonads was conducted, and the monthly distribution of maturity stages and oocyte diameters were monitored in an aggregate sample of 130 male and female silver carp, H. molitrix, (450-710 mm total length). The gonadosomatic index (GSI) ranged from 2.76 to 18.88% in females and from 0.34 to 1.85% in males. The female GSI values were the highest from June to August indicating the onset of the spawning season. The histological structures of the gonads revealed five different developmental stages in females and three stages in males. The oogenesis stages were the perinucleolar stage, the yolk vesicle stage, the primary yolk, the secondary yolk, and the tertiary yolk. Migratory nuclei and hydrated oocytes, which are considered to be the maturation stage, were not observed. Three different spermatogenesis phases (immature, maturing, and mature testis) were identified, which included final spermatozoa maturation.
Rare and interesting plant of Mahonia imbricata T.S. Ying & Boufford – an addition to India from the Manipur State
Authors: Dhatchanamoorthy Narayanasamy , Ravikumar Kaliamoorthy , Lokho Kreni , Tangavelou Arumugame Chanemougame , Begum Syed Noorunnisa 
Published: November 2019

Abstract

Mahonia imbricata was reported for the first time from Manipur, India. This paper describes taxonomy, morphology, phenology, habitat requirements, ecology and world distribution of the species. On the basis of the examined specimens, notes and photographs for easy identification are presented.
The results of a close follow-up of trainees to gain a good blood collection practice
Authors: Aykal Güzin , Esen Hatice , Öz Cemile , Yeğin Ayşenur 
Published: November 2019

SummaryBackgroundPhlebotomy is one of the most important steps in the preanalytical phase of a clinical laboratory process. In order to decrease phlebotomy errors, this specific procedure should be taught in detail by laboratory organizations. Our study aims to practice the training program on venous blood sampling and observe the close follow-up results.MethodsIn this observational study, 127 students who started their summer internship in Antalya Education and Research Hospital were given a one-day theoretical phlebotomy training in accordance with the Venous Blood Sampling Guidelines. After the theoretical training, phlebotomy applications of 10 students who were working in the field of out-patient blood sampling were observed both with and without their knowledge. A comprehensive checklist related to phlebotomy was created by the trainers in Antalya Education and Research Hospital and the observers answered each question as yes or no. For the statistical analysis, IBM SPSS Statistics 21.0 was used.ResultsAfter the theoretical education, the trainees were observed but no significant difference was found between the first and the second informed observations (p = 0.125). The students were observed three times more in the following week without their knowledge. There was a statistically significant difference between the first and the third unannounced observations (p=0.001).ConclusionsIn order to perform phlebotomy correctly, apart from theoretical education, a close follow-up is necessary too.
First records of bats from the Alatish National Park, north-western Ethiopia (Chiroptera)
Authors: Kruskop Sergei V. , Benda Petr , Vasenkov Denis A. , Lavrenchenko Leonid A. 
Published: November 2019

Abstract
The paper presents results of a first attempt to survey bats of the Alatish National Park (northwestern Ethiopia). Twenty-one bat species belonging to eight families and twelve genera were documented for the first time in the Park, at least two bat species (Hipposideros abae, Pipistrellus nanulus) were found new for the fauna of Ethiopia. The Alatish National Park is an area of high conservation value due to its high bat species diversity and a complex structure of the fauna including elements with various zoogeographic affinities.