bluuebunny/crossref_metadata_2025_split huggingface dataset:
Niche conservatism drives the elevational diversity gradient in major groups of free-living soil unicellular eukaryotes
Authors: Fernández Leonardo D. , Seppey Christophe V. W. , Singer David , Fournier Bertrand , Tatti Dylan , Mitchell Edward A. D. , Lara Enrique 
Published: December 2020

Abstract
Ancestral adaptations to warm and humid climates drive the biogeographical and macroecological patterns of numerous multicellular organisms. Recent evidence suggests that this niche conservatism may also be shaping broad-scale diversity patterns of soil unicellular organisms, although empirical evidence is limited to Acidobacteria and testate amoebae. Herein, we tested the predictions of this hypothesis for five major soil protist groups (Bacillariophyta, Cercomonadida, Ciliophora, Euglyphida and Kinetoplastida), separately, as well as combined, along an elevational gradient in Switzerland. We found support for the predictions of this hypothesis in all protist groups, including decreasing diversity and increasing geographical ranges towards high and cold elevations (Rapoport effect); correlations between diversity and temperature (species-energy effect); and communities phylogenetically structured by competition (phylogenetic overdispersion) at warm-humid sites and habitat filtering (phylogenetic clustering) at cold-humid sites. Mid-domain null models confirmed that these findings were not the result of stochastic processes. Our results therefore suggest that soil protists exhibit evolutionary constraints to warm and humid climates, probably linked to an ancestral adaptation to (sub)tropical-like environments, which limits their survival in exceedingly cold sites. This niche conservatism possibly drives their biogeographical and macroecological patterns both at the local (e.g., temperature, humidity gradients along elevation gradients) and more global (e.g., latitudinal gradients) spatial scales.
The Association Between Alcohol&nbsp;Consumption&nbsp;and Dysmenorrhea in University Students in North China&nbsp;
Authors: Yang Zhuo , Guo Jia , Sun Ming-li , He Qin-cheng , Ma Ya-Nan 
Published: December 2020

Abstract
Background: Dysmenorrhea is a condition frequently affecting menstruating women worldwide. Unfortunately, only a few studies have estimated the relationship between alcohol consumption and dysmenorrhea among women. In particular, there are fewer studies to explore the association between alcohol consumption, dysmenorrhea, and age at menarche. Objective: This study aimed to evaluate whether and to what extent alcohol consumption is related to dysmenorrhea and age at menarche. Methods: This was a cross-sectional, observational study conducted among college students. A total of 3,837 participants (age ≥18 years) volunteered to participate in the study and completed the questionnaire. Moreover, 145 were excluded from the study owing to exclusion criteria. We divided female college students into two groups stratified by age at menarche (AAM) 13 years. Logistic regression models were performed to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association of alcohol consumption with dysmenorrhea, adjusting for confounding factors. Results: A total of 3692 female college students completed the survey, including 409 (11.08%) who reported alcohol use. We found that alcohol consumption was not related to dysmenorrhea. However, stratified by age at menarche, we found that a positive association between alcohol consumption and dysmenorrhea among participants with AAM ≥13 years (OR,1.41; 95% CI, 1.06, 1.88). Compared with participants who reported no alcohol consumption, participants who reported consuming alcohol at least once a month (OR,1.29; 95% CI, 0.94, 1.78) and alcohol consumption at least once a week (OR,1.92; 95% CI, 1.07, 3.45) were more likely to have dysmenorrhea adjusting for other confounding factors. Conclusion: Our findings showed overall no association of alcohol consumption with dysmenorrhea but a statistically significant positive association for those whose AAM was >13 years.
Cutaneous Anthrax Outbreak Associated with Handling Dead Animals, Rhino Camp Sub-county: Arua District, Uganda, January-May 2018
Authors: Ntono Vivian , Eurien Daniel , Bulage Lilian , Kadobera Daniel , Harris Julie , Ario Alex Riolexus 
Published: December 2020

Abstract
Background: On the 9 February 2018, Arua District notified Uganda Ministry of Health of a confirmed anthrax outbreak among humans in Rhino Camp sub-county. About 9 persons fell ill after reported contact with livestock that died suddenly. We investigated to determine the scope, mode of transmission and exposures associated with identified anthrax, to guide control and prevention measures.Methods: We defined a suspected cutaneous anthrax case as onset of skin lesions (e.g., papule, vesicle, or eschar) in a person residing in Rhino Camp sub-county, Arua District from 25 December, 2017 to 31 May, 2018. A confirmed case was a suspected case with PCR-positivity for Bacillus anthracis from a clinical sample. We identified cases by reviewing medical records at Rhino Camp Health Centre. We also conducted additional case searches in the affected community with support from Community Health Workers. In a retrospective cohort study, we interviewed all members of households in which at least one person had contact with the carcasses of or meat from animals suspected to have died of anthrax. We collected and tested hides of implicated animals using an anthrax rapid diagnostic test.Results: We identified 14 case-patients (1 confirmed, 13 suspected); none died. Only males were affected (AR: 12/10,000). Mean age of case-persons was 33years (SD: 22).The epidemic curve shows that the outbreak lasted for 5 months, from January 2018-May 2018, peaking in February.Skinning(RR=2.7, 95%CI=1.1-6.7), dissecting (RR=3.0, 95%CI=1.2-7.6), and carrying the dead animals (RR=2.7, 95%CI=1.1-6.7) were associated with increased risk of illness, as were carrying dissected parts of the animal (RR=2.9, 95%CI 1.3-6.5) and preparing and cooking the meat (RR=2.3, 95%CI 2.7-8.1). We found evidence of animal remains on pastureland.Conclusion: Multiple exposures to the hides and meat of animals that died suddenly were associated with this cutaneous anthrax outbreak in Arua District. We recommended public education about safe disposal of carcasses of livestock that die suddenly.
LncRNA TSIX acts as a ceRNA of miR-342-3p to Promote the Progression of Nasopharyngeal Carcinoma by Regulating AGR2
Authors: Chen Shupeng , Zhang Qiongxia , Li Zhenyu , Qin Xintian , Wang Zhe , Liu Huimin , Mo Kailan , Wu Shaoyun , Li Yaoying , Wang Dan , Shi Zhi , He Xingxiang 
Published: December 2020

Abstract
Background: LncRNA TSIX has been observed to be abnormally expressed in many human cancers. However, its roles in nasopharyngeal carcinoma (NPC) remains unclear, and this study aims to explore the functions of TSIX in NPC.Methods: The expression of TSIX and miR-342-3p in NPC tissues and corresponding cell lines was detected by qRT-PCR. Bioinformatics analysis and luciferase activity assay and RIP assay were applied to determine the interaction between TSIX, miR-342-3p, and AGR2. The roles of TSIX, miR-342-3p and AGR2 in the proliferation, apoptosis, migration and invasion of NPC cells were explored both in vitro and in vivo. In addition, the rescue experiments were used to confirm the functions of TSIX, miR-342-3p, and AGR2 in NPC progression.Results: Our study firstly found that TSIX was significantly upregulated in NPC tissues and corresponding cell lines. Moreover, upregulation of TSIX obviously exacerbated the NPC progression including the proliferation, apoptosis, migration and invasion, while downregulation of TSIX efficiently attenuated the development of NPC. Further, our results demonstrated that TSIX could increase the expression of AGR2, which was directly targeted by miR-342-3p, and then lead to the facilitated development of NPC cells.Conclusion: In summary, our study revealed that lncRNA TSIX promoted the progression of NPC through targeting miR-342-3p/AGR2 axis, suggested that it might be a potential therapeutic target for NPC.
Impact of Metaheuristic Techniques in Pandemic of COVID-19
Authors: Kumar Vijay , Singh Dilbag , Kaur Manjit 
Published: December 2020

:
The early detection and diagnosis of novel coronavirus disease 2019 (COVID-19) are required
to cure the disease. Metaheuristic techniques can be used to develop an automated tool for
detecting the symptoms of an infected person and provide appropriate precautionary measures. The
metaheuristic-based software can be designed to analyze the radiographic patterns of infected individuals
and determine the severity of COVID-19 infection. The genome structure of coronavirus
can be easily understood through metaheuristic techniques. Based on the genome structure, an effective
drug combination can be explored by using metaheuristics for the treatment of COVID-19.
PENYULUHAN INOVASI PRODUK DAN PEMASARAN INDUSTRI KECIL PANGAN DI DESA GUNUNG MANIK TANJUNGSARI SUMEDANG
Authors: Djuwendah Endah , Karyani Tuti 
Published: December 2020

Industri kecil pangan merupakan salah satu potensi pengerak perekonomian di perdesaan karena dapat menciptakan nilai tambah dan peluang kesempatan kerja. Menciptakan inovasi pada industri kecil pangan adalah hal yang sangat penting untuk meningkatkan daya saing dan nilai penjualan. Penggunaan sistem informasi pemasaran dapat membantu pelaku industri kecil pangan dalam membuat alternatif pemasaran guna meningkatkan volume penjualan. Kegiatan penyuluhan inovasi produk dan pemasaran on line di Desa Gunung Manik merupakan wujud dari penerapan teknologi yang ada pada UndangUndang Nomor 12 Tahun 2012 tentang Pendidikan Tinggi, sehingga diharapkan dapat meningkatkan pendapatan masyarakat desa. Inovasi yang dilakukan meliputi penambahan varian rasa , bentuk dan pengemasan produk ladu. Selain Pelatihan hal lain yang dibutuhkan oleh warga masyarakat adalah media yang membantu dalam memasarkan produk melalui sistem informasi pemasaran dan media sosial seperti Web penjualan, facebook, instagram dan twitter. Materi penyuluhan yang diberikan pada kegiatan PPM ini adalah motivasi dan mental kewirausahaan, inovasi produk dan pengemasan, pemasaran online, sosialisasi keamanan pangan dan tatacara pengajuan sertifikasi P-IRT. Faktor pendorong keberhasilan program adalah adanya dukungan aparat desa dan partisipasi aktif warga masyarakat desa Gunung Manik.
Peningkatan Kedisiplinan Siswa Masuk Kelas melalui Layanan Konseling Kelompok dengan Pendekatan Behavioral
Authors: Lutiyem Lutiyem 
Published: December 2020

Permasalahan dalam penelitian tindakan bimbingan ini adalah rendahnya tingkat kedisiplinan siswa masuk kelas pada siswa kelas VIIIA SMP Negeri 1 Talang tahun Pelajaran 2019/2020. Untuk mengatasi masalah tersebut, peneliti melakukan penelitian tindakan kelas selama 2 siklus yang setiap siklusnya dilaksanakan dalam 2 kali pertemuan dengan menggunakan layanan Konseling kelompok dengan pendekatan behavioral. Dari hasil pengamatan menunjukkan adanya peningkatan kedisiplinan siswa masuk kelas datang tepat waktu pada prasiklus terlambat 13 siswa (40,63%), bolos 6 siswa (18,75%), alpa 10 siswa 31,25%). Setelah diadakan tindakan pada siklus 1, terlambat 6 siswa (18,75%), bolos 3 siswa (9,36%),alpa 6 siswa (24%). Pada siklus 2 mengalami peningkatan yang signifikan terlambat 3 siswa (9,36%), bolos ( 0% ),alpa 2 siswa (5,8%). Hal ini menunjukkan adanya peningkatan kedisiplinan siswa masuk kelas/sekolah. Berdasarkan hasil penelitian tersebut, maka dapat disimpulkan bahwa model Konseling kelompok dengan pendekatan behavioral terbukti dapat meningkatkan kedisiplinan siswa masuk kelas pada siswa VIIIA semester 2 SMP Negeri 1 Talang Tahun Pelajaran 2019/2020.
PERHITUNGAN CHANGE ORDER PROYEK JALAN DI BANTEN
Authors: Waty Mega , Sulistio Hendrik 
Published: December 2020

ABSTRACTChange orders include a number of variants in the scope of work namely the amount of material, design errors, and price changes. This paper discusses change orders in a road construction project in Banten by investigating the causes, studying their effects on the project, and identifying the beneficiaries. The study used five road projects as actual case studies and the questionnaire used a six-point Likert Scale. To determine the ranking of factors that influence the causes of change orders, the effect of change orders and the factors that benefit from change orders are used the Relative Importance Index (RII) calculation. The most important effects of change orders on projects are found to be schedule delays, cost overruns and disputes. The contractor as the party that benefits the most from the change order is followed by the consultant and then the owner. Keywords: change order; road project; Relative Importance Index (RII) ABSTRAK Change order mencakup sejumlah varian dalam ruang lingkup pekerjaan yakni jumlah material, kesalahan desain, dan perubahan harga. Makalah ini membahas change order dalam proyek konstruksi jalan di Banten dengan menyelidiki penyebab, mempelajari efeknya pada proyek, dan mengidentifikasi pihak-pihak yang diuntungkan. Penelitian menggunakan lima proyek jalan sebagai studi kasus aktual dan Kuisoner menggunakan Skala Likert Enam poin. Untuk mengetahui peringkat faktor yang mempengaruhi penyebab change order, efek change order dan faktor yang diuntungkan dari change order digunakan perhitungan Relative Importance Index (RII). Efek terpenting dari change order pada proyek ditemukan adalah penundaan jadwal, pembengkakan biaya dan perselisihan. Kontraktor selaku pihak yang paling diuntungkan dari change order diikuti oleh konsultan dan kemudian owner.
PENGARUH RIWAYAT MELAHIRKAN BAYI LEBIH DARI 4000 GRAM TERHADAP KEJADIAN DIABETES MELITUS TIPE 2 PADA WANITA USIA SUBUR DIWILAYAH KERJA PUSKESMASPINTUPADANG KABUPATEN TAPANULI SELATAN
Authors: Nasution Lisna Khairani 
Published: December 2020

Diabetes mellitus (DM) is a chronic disease caused by the incapability of the body to produce insulin hormone or by the ineffective use that hormone. It is indicated by the high level of glucose in blood. It ranks the sixth as the cause of death throughout the world. The objective of the research was to find out some factors influencing the incidence of DM Type 2 in RAW (reproductive age women) in the working area of Puskesmas Pintupadang. The research used observational analytic method with case-control design of 62 respondents. The data were analyzed by using bivariate analysis with Chi- square test. The result showed that there was noinfluence of thehistory of giving birth to babies with > 4,000 grams on the incidence of DM Type 2 in RAW(p=1,000; OR=1,193 ;95% CI= 0,37-3,82). There are suggestions for health workers at the health center so that they can improve services optimally, especially in providing various knowledge about how to control blood glucose levels so that the number of people with type 2 diabetes can be reduced and for the general public (women of fertile age) especially those who have a family history of diabetes so that it can reduce the contribution of the Infant Mortality Rate (IMR) and the Maternal Mortality Rate (MMR). Keywords: DM Type 2; history of Childbirth; reproductive age women ABSTRAKDiabetes Melitusmerupakanpenyakitkronis yang disebabkan oleh ketidakmampuan tubuh untuk memproduksi hormon insulin atau karena penggunaan yang tidak efektif dari hormon itu. Hal ini ditandai dengan tingginya kadar gula dalam darah. DM menduduki peringkat ke 6 sebagai penyebab kematian di dunia. Penelitianinibertujuanuntuk mengetahui faktor-faktor yang memengaruhi kejadian DM tipe 2 pada WUS di Wilayah Kerja Puskesmas Pintupadang. Penelitian ini merupakan penelitian analitik observasional dengan desain kasus kontrol dimana sampel kasus dan kontrol berjumlah 62 orang. Metode analisis data yang digunakan adalah analisis bivariat dengan uji chi square. Hasil penelitian menunjukkan bahwa tidak ada pengaruh riwayat melahirkan bayi>4000 gram dengan kejadian DM tipe 2 pada WUS dengan nilai (p=1,000; OR=1,193; 95% CI= 0,37-3,82). Adapun saran bagi Petugas Kesehatan di Puskesmas agar dapat meningkatkan pelayanan secara optimal terutama dalam memberikan berbagai pengetahuan tentang cara pengendalian kadar glukosa darah sehingga jumlah penderita DM tipe 2 dapat diturunkan dan bagi Masyarakat Umum (Wanita Usia Subur) khususnya yang memiliki riwayat keluarga DM sehingga dapat mengurangi peyumbangan Angka Kematian Bayi (AKB) dan Angka Kematian Ibu (AKI).
EFEKTIVITAS PEMBERIAN EKSTRAK BIJI KETUMBAR TERHADAP GAMBARAN SEL BUSA ATEROSKLEROSIS AORTA ABDOMINALIS TIKUS HIPERKOLESTEROLEMIA DIABETES
Authors: Giopratiwi Kusvandita , Thadeus Maria Selvester , Yulianti Retno 
Published: December 2020

Coriander Seed Extract (CSE) is thought to have the potential to repair foam cell formation process which is part of atherosclerotic lesion. The aim of this study is to identify the effects of coriander seed extract on histopathological features of atherosclerotic foam cells abdominal aorta in rats hypercholesterolemia diabetes model. The study was conducted for 63 days. 30 Wistar outbred rats were grouped into five groups, each group consist of 6 rats. Negative control group (standar feed), positive control group (high fat diet and alloxan + glibenclamide 0.045 mg), treatment group 1 (high fat diet and alloxan + CSE 300 mg/kgBB/day), treatment group 2 (high fat diet and alloxan + CSE 500 mg/kgBB/day), treatment group 3 (high fat diet and alloxan + CSE 700 mg/kgBB/day). After the treatment were given to each group, the next procedure were dissection, extraction of the aorta abdominal organ, and histopathological examination of foam cell. Data were analyzed with One Way ANOVA test and Post Hoc Bonferoni test show there are significant difference (P value = 0.049) between positive control group and treatment group 3. In conclusion, CSE 700 mg/kgBB dose can reduce foam cell formation. Keywords: atherosclerosis; coriander seed extract; foam cell; hypercholesterolemia. ABSTRAK Ekstrak biji ketumbar (EBJ) diduga memiliki potensi untuk memperbaiki proses pembentukan sel busa lesi aterosklerosis. Penelitian ini bertujuan untuk mengetahui efektivitas pemberian ekstrak biji ketumbar terhadap gambaran histopatologi sel busa aterosklerosis aorta abdominalis tikus model hiperkolesterolemia diabetes. Penelitian dilakukan selama 63 hari. Sebanyak 30 ekor tikus Galur Wistar outbred dibagi ke dalam 5 kelompok, masing-masing kelompok terdiri dari 6 ekor. Kelompok kontrol negatif (pakan standar), kelompok kontrol positif (pakan tinggi lemak dan aloksan + glibenklamid 0.045 mg), kelompok perlakuan 1 (pakan tinggi lemak dan aloksan + EBJ 300 mg/kgBB/hari), kelompok perlakuan 2 (pakan tinggi lemak dan aloksan + EBJ 500 mg/kgBB/hari), dan kelompok perlakuan 3 (pakan tinggi lemak dan aloksan + EBJ 700 mg/kgBB/hari). Setelah perlakuan, dilakukan pembedahan dan pengambilan organ aorta abdominalis lalu dibuat preparat untuk menilai gambaran sel busa. Analisis statistika dengan Uji One Way ANOVA dan uji Post Hoc Bonferoni menunjukkan ada perbedaan signifikan (P Value=0.049) antara kelompok kontrol positif dengan kelompok perlakuan 3. Kesimpulannya, EBJ dosis 700 mg/kgBB/hari memiliki efektivitas untuk menurunkan pembentukan sel busa dalam proses aterosklerosis.
AUDIT KESELAMATAN JALAN TOL JAGORAWI
Authors: Setyarini Ni Luh Shinta Putu Eka , Lukito Bryan Ivan 
Published: December 2020

Jagorawi toll road is a link road needed to speed up travel time from Jakarta to Bogor and Ciawi, the condition of Jagorawi is currently very congested resulting in an increasing number of traffic accidents. To improve road traffic safety on toll roads, it's necessary to carry out Road Safety Audits (RSA). Aspects of the road that become objects to examine and direct observations included geometric aspects, traffic management, pavement, road complementary buildings and street furnitures. As a result, in geometric aspect, in general the road has been designed in accordance regulations, however, there are parts of the toll road that still require repair. This research will discuss regard the condition of Jagorawi toll road based on direct observations carried out in the field by using road safety audit form for operational roads. The aim is, accident-prone areas are obtained on Jagorawi toll road with analysis of the results of direct observations, and from traffic accident data obtained from Jasa Marga Keywords: Accident Prone Areas; Road Safety Audit; Toll RoadABSTRAK Ruas jalan tol Jagorawi merupakan jalan bebas hambatan yang dibutuhkan untuk mempercepat waktu tempuh dari Jakarta ke Bogor dan Ciawi, kondisi jalan tol Jagorawi saat ini sangat padat yang berakibat kepada meningkatnya jumlah kecelakaan lalu lintas. Dalam upaya meningkatkan keselamatan lalu lintas jalan di jalan tol, maka perlu melaksanakan Audit Keselamatan Jalan (AKJ). Aspek jalan yang menjadi objek untuk diperiksa meliputi aspek geometrik jalan, manajemen lalu lintas, bangunan pelengkap jalan dan pelengkap jalan. Hasilnya, dari segi geometrik, secara umum jalan sudah dirancang sesuai dengan ketentuan yang berlaku, namun, terdapat bagian-bagian dari jalan tol yang masih memerlukan perbaikan. Penelitian ini akan membahas mengenai kondisi eksisting jalan Tol Jagorawi berdasarkan pengamatan langsung yang dilaksanakan di lapangan dengan mempergunakan formulir audit keselamatan jalan untuk jalan yang sudah operasional. Aspek yang ditinjau adalah aspek geometrik, perkerasan, bangunan pelengkap jalan dan pelengkap jalan. Sebagai hasil akhir, didapat daerah rawan kecelakaan pada ruas Tol Jagorawi dengan analisis dari hasil pengamatan langsung, dan dari data kecelakaan lalu lintas yang diperoleh dari Jasa Marga.
Factor Associated with Diabetes Burnout Syndrome Among Type 2 Diabetes Mellitus
Authors: Nuari Nian Afrian 
Published: December 2020

Diabetes mellitus is a metabolic disease that is often found in Indonesia and the number of sufferers is increasing every time. Management of therapy patients with type 2 diabetes mellitus consists of five steps that require compliance and discipline to maintain stable blood sugar levels. This condition causes burnout by diabetes mellitus patients. The purpose of this study was to identify factors associated with diabetes mellitus among type 2 Diabetes mellitus. This study used a correlational design with a cross-sectional approach with a sample size of 89 respondents who were taken by purposive sampling. Based on the results of the study it was found that most Diabetes mellitus patients were 56-60 years old, female, and the education background was junior high school level. The level of income of majority of the respondents was under 1 million rupiahs andÂ suffered from Diabetes mellitus for 1-10 years. The result found almost the entire entire patient consumed diabetes drugs. Most of the respondents had a severe category in diabetes burnout syndrome. The research found that there was a correlation between age, gender educational background, level of income, duration suffering DM, consumption of diabetes drugs with diabetes burnout syndrome among type 2 Diabetes Mellitus. Health workers must provide education about the importance of preventing the incidence of burnout syndrome and taking therapeutic management for patients who already had diabetes burnout syndrome.