bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thrombotic circuit complications during venovenous extracorporeal membrane oxygenation in COVID-19
Authors: Bemtgen Xavier , Zotzmann Viviane , Benk Christoph , Rilinger Jonathan , Steiner Katrin , Asmussen Alexander , Bode Christoph , Wengenmayer Tobias , Maier Sven , Staudacher Dawid L. 
Published: July 2020

AbstractThe novel coronavirus SARS-CoV-2 and the resulting disease COVID-19 causes pulmonary failure including severe courses requiring venovenous extracorporeal membrane oxygenation (V-V ECMO). Coagulopathy is a known complication of COVID-19 leading to thrombotic events including pulmonary embolism. It is unclear if the coagulopathy also increases thrombotic circuit complications of the ECMO. Aim of the present study therefor was to investigate the rate of V-V ECMO complications in COVID-19. We conducted a retrospective registry study including all patients on V-V ECMO treated at our centre between 01/2018 and 04/2020. COVID-19 cases were compared non- COVID-19 cases. All circuit related complications resulting in partial or complete exchange of the extracorporeal system were registered. In total, 66 patients were analysed of which 11 (16.7%) were SARS-CoV-2 positive. The two groups did not differ in clinical parameters including age (COVID-19 59.4 vs. non-COVID-19 58.1 years), gender (36.4% vs. 40%), BMI (27.8 vs. 24.2) and severity of illness as quantified by the RESP Score (1pt. vs 1pt.). 28 days survival was similar in both groups (72.7% vs. 58.2%). While anticoagulation was similar in both groups (p = 0.09), centrifugal pump head thrombosis was more frequent in COVID-19 (9/11 versus 16/55 p < 0.01). Neither the time to first exchange (p = 0.61) nor blood flow at exchange (p = 0.68) did differ in both groups. D-dimer levels prior to the thrombotic events were significantly higher in COVID-19 (mean 15.48 vs 26.59, p = 0.01). The SARS-CoV-2 induced infection is associated with higher rates of thrombotic events of the extracorporeal system during V-V ECMO therapy.
Entrepreneurship of an institutional field: the emergence of coworking spaces for digital business models
Authors: Bouncken Ricarda B. , Kraus Sascha , Martínez-Pérez Juan F. 
Published: July 2020

AbstractCoworking spaces have been proliferating world-wide in urban and rural areas while facilitating entrepreneurship and new, especially digital business models. Our research analyzes the worldwide expansion by drawing upon mechanisms from institutional theory. We argue that the sense of community, emotional activation, the local communities together with the digital linkages and the open office allowed coworking spaces to evolve as a real space for entrepreneurship. The common lifestyle and the high digital identity of the users further explain the emergence of this entrepreneurship field that shows high convergent forms of coworking spaces. The key divergence comes with different ownership models.
Imaging for central nervous system (CNS) interstitial fluidopathy: disorders with impaired interstitial fluid dynamics
Authors: Taoka Toshiaki , Naganawa Shinji 
Published: July 2020

AbstractAfter the introduction of the glymphatic system hypothesis, an increasing number of studies on cerebrospinal fluid and interstitial fluid dynamics within the brain have been investigated and reported. A series of diseases are known which develop due to abnormality of the glymphatic system including Alzheimer’s disease, traumatic brain injury, stroke, or other disorders. These diseases or disorders share the characteristics of the glymphatic system dysfunction or other mechanisms related to the interstitial fluid dynamics. In this review article, we propose “Central Nervous System (CNS) Interstitial Fluidopathy” as a new concept encompassing diseases whose pathologies are majorly associated with abnormal interstitial fluid dynamics. Categorizing these diseases or disorders as “CNS interstitial fluidopathies,” will promote the understanding of their mechanisms and the development of potential imaging methods for the evaluation of the disease as well as clinical methods for disease treatment or prevention. In other words, having a viewpoint of the dynamics of interstitial fluid appears relevant for understanding CNS diseases or disorders, and it would be possible to develop novel common treatment methods or medications for “CNS interstitial fluidopathies.”
Novel ion drift tube for high-performance ion mobility spectrometers based on a composite material
Authors: Ahrens André , Möhle Janina , Hitzemann Moritz , Zimmermann Stefan 
Published: July 2020

AbstractIon mobility spectrometers (IMS) are able to detect pptV-level concentrations of substances in gasses and in liquids within seconds. Due to the continuous increase in analytical performance and reduction of the instrument size, IMS are established nowadays in a variety of analytical field applications. In order to reduce the manufacturing effort and further enhance their widespread use, we have developed a simple manufacturing process for drift tubes based on a composite material. This composite material consists of alternating layers of metal sheets and insulator material, which are connected to each other in a mechanically stable and gastight manner. Furthermore, this approach allows the production of ion drift tubes in just a few steps from a single piece of material, thus reducing the manufacturing costs and efforts. Here, a drift tube ion mobility spectrometer based on such a composite material is presented. Although its outer dimensions are just 15 mm × 15 mm in cross section and 57 mm in length, it has high resolving power of Rp = 62 and detection limits in the pptV-range, demonstrated for ethanol and 1,2,3-trichloropropane.
Validation of the 3-variable prognostic score (3-PS) in mCRPC patients treated with 223Radium-dichloride: a national multicenter study
Authors: Frantellizzi Viviana , Monari Fabio , Mascia Manlio , Costa Renato , Rubini Giuseppe , Spanu Angela , Di Rocco Arianna , Lodi Rizzini Elisa , Cindolo Luca , Licari Maria , Lavelli Valentina , Nuvoli Susanna , De Angelis Cristina , Dionisi Valeria , Ferrari Cristina , De Vincentis Giuseppe 
Published: July 2020

Abstract
Objective
Radium-223 (223Ra) has been approved for treatment in patients with metastatic castration-resistant prostatic cancer (mCRPC) and bone metastasis. This α-emitting radionuclide has a beneficial effect on pain and is also capable to increase overall survival (OS). Several studies evaluated the prognostic value of different biomarkers at baseline, such as serum values, imaging parameters or pain. To date, however, clinicians lack a validated and simple system to assess which patients will most likely benefit from 223Ra treatment. The 3-variable prognostic score (3-PS), proposed in a single-center study in 2017 classifies patients in five prognostic groups with a specific OS. This study aims to validate the 3-PS in a larger multicenter population.

Methods
Four hundred and thirty mCRPC patients treated with 223Ra from six different centers were analyzed. The 3-PS score consists of the collection of baseline hemoglobin, prostatic specific antigen and Eastern cooperative oncology group performance status and was initially applied to the whole population (total group). The score was then validated on the 338 patient’s subgroup (clean group) obtained by subtracting the 92 patients enrolled for the original study of the 3-PS score. This purified group served as further validation evidence.

Results
Statistical analysis showed that the 3-PS score was valid on the total group as well as in the clean group as the AUC estimated (0.74) falls within the CI of the AUC calculated on the validation sample (95% CI 0.66–0.82).

Conclusion
This study confirms the validity of the 3-PS score for mCRPC patients. This score is simple, noninvasive and affordable and can be easily used to select patients that will most probably complete 223Ra treatment. In addition, this tool provides an exact estimate of life expectancy in terms of OS.
Introspective Interest and Insight in the Context of Mindfulness-Based Stress Reduction: a Randomized Trial
Authors: Nyklíček Ivan , Zonneveld Renée , Denollet Johan 
Published: July 2020

Abstract
Objective
Introspective interest and insight have long been argued to be important factors in psychotherapy. However, empirical studies are scarce and their results equivocal. Therefore, in the present study, the potential moderating and mediating roles of introspective interest and insight were examined in the context of mindfulness-based stress reduction (MBSR).

Methods
In a randomized controlled trial, 72 MBSR participants were compared with 71 waitlist control participants. Their mean age was 46.1 years (SD = 10.3), 31.5% were male and all were white. Pre-to-post changes in mood, perceived stress, quality of life, mindfulness skills, and introspective interest and insight were compared between the groups and the moderating and mediating effects of introspective interest and insight were examined, adjusting for effects of mindfulness skills.

Results
Introspective interest nor insight moderated the effects of MBSR. However, increase in insight, but not interest, significantly mediated favorable effects of MBSR on all outcome variables, over and above changes in mindfulness skills: perceived stress (B = − 1.43, 95% CI − 2.63 to − 0.54), negative affect (B = − 0.11, 95% CI − 0.23 to − 0.00), positive affect (B = 0.12, 95% CI 0.03–0.23) and psychological quality of life (B = 0.16, 95% CI 0.02–0.34).

Conclusions
Increase in introspective insight may form a potentially important mechanism of the effectiveness of mindfulness-based interventions, and possibly also other psychological interventions.
Immersive virtual reality as a pedagogical tool in education: a systematic literature review of quantitative learning outcomes and experimental design
Authors: Hamilton D. , McKechnie J. , Edgerton E. , Wilson C. 
Published: July 2020

AbstractThe adoption of immersive virtual reality (I-VR) as a pedagogical method in education has challenged the conceptual definition of what constitutes a learning environment. High fidelity graphics and immersive content using head-mounted-displays (HMD) have allowed students to explore complex subjects in a way that traditional teaching methods cannot. Despite this, research focusing on learning outcomes, intervention characteristics, and assessment measures associated with I-VR use has been sparse. To explore this, the current systematic review examined experimental studies published since 2013, where quantitative learning outcomes using HMD based I-VR were compared with less immersive pedagogical methods such as desktop computers and slideshows. A literature search yielded 29 publications that were deemed suitable for inclusion. Included papers were quality assessed using the Medical Education Research Study Quality Instrument (MERSQI). Most studies found a significant advantage of utilising I-VR in education, whilst a smaller number found no significant differences in attainment level regardless of whether I-VR or non-immersive methods were utilised. Only two studies found clear detrimental effects of using I-VR. However, most studies used short interventions, did not examine information retention, and were focused mainly on the teaching of scientific topics such as biology or physics. In addition, the MERSQI showed that the methods used to evaluate learning outcomes are often inadequate and this may affect the interpretation of I-VR’s utility. The review highlights that a rigorous methodological approach through the identification of appropriate assessment measures, intervention characteristics, and learning outcomes is essential to understanding the potential of I-VR as a pedagogical method.
Curtailing Carbon Usage with Addition of Functionalized NiFe2O4 Quantum Dots: Toward More Practical S Cathodes for Li–S Cells
Authors: Li Ning , Meng Ting , Ma Lai , Zhang Han , Yao JiaJia , Xu Maowen , Li Chang Ming , Jiang Jian 
Published: July 2020

AbstractSmart combination of manifold carbonaceous materials with admirable functionalities (like full of pores/functional groups, high specific surface area) is still a mainstream/preferential way to address knotty issues of polysulfides dissolution/shuttling and poor electrical conductivity for S-based cathodes. However, extensive use of conductive carbon fillers in cell designs/technology would induce electrolytic overconsumption and thereby shelve high-energy-density promise of Li–S cells. To cut down carbon usage, we propose the incorporation of multi-functionalized NiFe2O4 quantum dots (QDs) as affordable additive substitutes. The total carbon content can be greatly curtailed from 26% (in traditional S/C cathodes) to a low/commercial mass ratio (~ 5%). Particularly, note that NiFe2O4 QDs additives own superb chemisorption interactions with soluble Li2Sn molecules and proper catalytic features facilitating polysulfide phase conversions and can also strengthen charge-transfer capability/redox kinetics of overall cathode systems. Benefiting from these intrinsic properties, such hybrid cathodes demonstrate prominent rate behaviors (decent capacity retention with ~ 526 mAh g−1 even at 5 A g−1) and stable cyclic performance in LiNO3-free electrolytes (only ~ 0.08% capacity decay per cycle in 500 cycles at 0.2 A g−1). This work may arouse tremendous research interest in seeking other alternative QDs and offer an economical/more applicable methodology to construct low-carbon-content electrodes for practical usage.
Warm Atlantic Water Explains Observed Sea Ice Melt Rates North of Svalbard
Authors: Duarte Pedro , Sundfjord Arild , Meyer Amelie , Hudson Stephen R. , Spreen Gunnar , Smedsrud Lars H. 
Published: July 2020

AbstractWarm Atlantic water (AW) that flows northward along the Svalbard west coast is thought to transport enough heat to melt regional Arctic sea ice effectively. Despite this common assumption, quantitative requirements necessary for AW to directly melt sea ice fast enough under realistic winter conditions are still poorly constrained. Here we use meteorological data, satellite observations of sea ice concentration and drift, and model output to demonstrate that most of the sea ice entering the area over the Yermak Plateau melts within a few weeks. Simulations using the Los Alamos Sea Ice Model (CICE) in a 1‐D vertically resolved configuration under a relatively wide range of in situ observed atmospheric and ocean forcing show a good fit to observations. Simulations require high‐frequency atmospheric forcing data to accurately reproduce vertical heat fluxes between the ice or snow and the atmosphere. Moreover, we switched off hydrostatic equilibrium to properly reproduce ice and snow thickness when observations showed that ice had a negative freeboard, without surface flooding and snow‐ice formation. This modeling shows that realistic melt rates require a combination of warm near‐surface AW and storm‐induced ocean mixing. However, if AW is warmer than usual (>5°C), then lower mixing rates are sufficient. Our results suggest that increased winter storm frequency and increased heat content of the AW may work together in reducing future sea ice cover in the Eurasian basin.
Large‐Eddy Simulation of Turbulent Oscillatory Flow Over Three‐Dimensional Transient Vortex Ripple Geometries in Quasi‐Equilibrium
Authors: Chalmoukis Iason A. , Dimas Athanassios A. , Grigoriadis Dimokratis G. E. 
Published: July 2020

AbstractVortex ripples induced by oscillatory flow display straight crests at equilibrium, but they develop transient three‐dimensional (3‐D) bedform geometries when transitioning from one equilibrium state to another due to changes in the oscillatory flow. Large‐eddy simulations were performed of oscillatory flow over 3‐D bedform defects associated with an increase of the orbital motion amplitude, similar to what might happen during the waxing phase of a storm. The objective is to determine the intercorrelation between flow processes and evolution of 3‐D bedform defects toward an equilibrium two‐dimensional (2‐D) state of vortex ripples. Results are presented for oscillatory flows over fixed ripples with sinusoidal crests in the spanwise direction, which introduce slope asymmetries on opposite sides of the crests, during different transient states. It was found that steep‐sloped regions of the bedforms are associated with thicker recirculation areas, whereas in more gently sloped regions thinner recirculation vortices exist. Furthermore, streamwise vortical structures and significant secondary flow develop in the vicinity of sinusoidal crests, relative to straight crests. These flow structures might be responsible for the gradual reformation of the rippled bed, as they induce higher bed shear stresses, that is, increasing bed sediment transport, and they diffuse turbulent kinetic energy to higher levels above crests, that is, increasing suspended sediment transport, relative to equilibrium 2‐D ripples. Finally, the period‐averaged currents around the sinusoidal crests exhibit higher velocities on the steep‐sloped side than on the mild‐sloped one, also likely contributing to sediment transport and bed reformation toward a 2‐D configuration.
Ooid Cortical Stratigraphy Reveals Common Histories of Individual Co‐occurring Sedimentary Grains
Authors: Trower Elizabeth J. , Bridgers Sophia L. , Lamb Michael P. , Fischer Woodward W. 
Published: July 2020

AbstractOoids are a common type of carbonate sand grain that form through a combination of constructive and destructive mechanisms: growth via precipitation and diminution via physical abrasion. Because growth and abrasion obey distinct morphometric rules, we developed an approach to quantitatively constrain the history of growth and abrasion of individual ooid grains using the record of evolving particle shape preserved by their cortical layers. We designed a model to simulate >106 possible growth‐abrasion histories for each pair of cortical layer bounding surfaces in an individual ooid. Estimates for the durations of growth and abrasion of each cortical layer were obtained by identifying the simulated history that best fit the observed particle shape. We applied this approach to thin sections of “modern” lacustrine ooids collected from several locations in the Great Salt Lake (GSL), UT, to assess the spatial and temporal variability of environmental conditions from the perspective of individual grains within a single deposit. We found that GSL ooids do not all share the same histories: Clustering ooid histories by a Fréchet distance metric revealed commonalities between grains found together locally within a deposit but distinct differences between subpopulations shared among localities across the GSL. These results support the tacit view that carbonate sedimentary grains found together in the environment do reflect a common history of sediment transport. This general approach to invert ooid cortical stratigraphy can be applied to characterize environmental variability over <1,000 year timescales in both marine and lacustrine ooid grainstones of any geologic age.
A Framework to Quantify the Uncertainty Contribution of GCMs Over Multiple Sources in Hydrological Impacts of Climate Change
Authors: Wang Hui‐Min , Chen Jie , Xu Chong‐Yu , Zhang Jianke , Chen Hua 
Published: July 2020

AbstractThe quantification of climate change impacts on hydrology is subjected to multiple uncertainty sources. Large ensembles of hydrological simulations based on multimodel ensembles (MMEs) have been commonly applied to represent overall uncertainty of hydrological impacts. However, as increasing numbers of global climate models (GCMs) are being developed, how many GCMs in MMEs are sufficient to characterize overall uncertainty is not clear. Therefore, this study investigates the influences of GCM quantity on quantifying overall uncertainty and uncertainty contributions of multiple sources in hydrological impacts. Large ensembles of hydrological simulations are obtained through the permutation of 3 greenhouse gas emission scenarios, 22 GCMs, 6 downscaling techniques, 5 hydrological models (HMs), and 5 sets of HM parameters, which enables to decompose uncertainty components using analysis of variance. The influences of GCM quantity are investigated by repeatedly conducting uncertainty decomposition for hydrological simulations from subsets with different numbers of GCMs. The results show that GCMs are the leading uncertainty sources in evaluating changes in annual and peak streamflows, while for changes in low flow, other uncertainty sources except HM parameters also have large contributions to overall uncertainty. Furthermore, on the condition of using no more than five GCMs, there are large possibilities that the overall uncertainty and GCMs' uncertainty contribution are underestimated. Using around 10 GCMs can ensure that the median of different combinations generates similar uncertainty components as the whole ensemble. Therefore, it is recommended to use at least 10 GCMs in studies of climate change impacts on hydrology to thoroughly quantify uncertainty.
A Drift‐Kinetic Method for Obtaining Gradients in Plasma Properties From Single‐Point Distribution Function Data
Authors: Wetherton B. A. , Egedal J. , Montag P. K. , Lê A. , Daughton W. S. 
Published: July 2020

AbstractIn this paper, we derive a new drift‐kinetic method for estimating gradients in the plasma properties through a velocity space distribution at a single point. The gradients are intrinsically related to agyrotropic features of the distribution function. This method predicts the gradients in the magnetized distribution function and can predict gradients of arbitrary moments of the gyrotropic background distribution function. The method allows for estimates on density and pressure gradients on the scale of a Larmor radius, proving to resolve smaller scales than any method currently available to spacecraft. The model is verified with a set of fully kinetic VPIC particle‐in‐cell simulations.
IONISE: An Ionospheric Observational Network for Irregularity and Scintillation in East and Southeast Asia
Authors: Sun Wenjie , Wu Baoyuan , Wu Zhi , Hu Lianhuan , Zhao Xiukuan , Zheng Jianchang , Xie Haiyong , Yang Sipeng , Ning Baiqi , Li Guozhu 
Published: July 2020

AbstractAn Ionospheric Observational Network for Irregularity and Scintillation in East and Southeast Asia (IONISE) is developed to identify and study the short‐term and fine‐scale ionospheric variations over China. The IONISE network mainly includes three crossed chains of Beidou geostationary satellite total electron content (TEC)/scintillation receivers along 110°E, 23°N, and 40°N respectively, multistatic portable digital ionosondes and bistatic very high‐frequency radars. Based on the IONISE observations, we report some preliminary results of ionospheric disturbances and irregularities, including (1) initially generated and zonally drifting equatorial plasma bubbles and related scintillations, (2) traveling ionospheric disturbances from middle to low latitudes, (3) drift of strong sporadic E structures over a wide area of more than 1,000 km, (4) fine‐scale ionospheric perturbation and regional TEC gradient, and (5) general features of ionospheric response to geomagnetic storms. Possible mechanisms responsible for these ionospheric phenomena are discussed. The IONISE provides new data set for investigation on ionospheric disturbances of various scales in a broad region with dense observations along specific latitude/longitude.