bluuebunny/crossref_metadata_2025_split huggingface dataset:
Derlin‐1 exhibits oncogenic activities and indicates an unfavorable prognosis in breast cancer
Authors: Zeng Jinsheng , Tian Qiuhong , Zeng Zhimin , Cai Jing , Ye Meiyu , Liu Yaxiong , Liu Anwen 
Published: October 2019

AbstractDerlin‐1 is involved in the elimination of misfolded proteins and has been implicated in the progression of human cancers. However, its prognostic value and biological function in breast cancer remain unknown. Here, we show that Derlin‐1 is overexpressed in breast cancer and exhibits oncogenic activities via interaction with UBE2C. Increased expression of Derlin‐1 is correlated with lymph node metastasis, advanced clinical stage, and unfavorable overall survival in two cohorts containing over 1,000 patients. Multivariate analyses by the Cox regression model suggest Derlin‐1 is an independent factor for poor prognosis. In vitro experiments demonstrate that Derlin‐1 expression is transcriptionally upregulated by c‐Myc. Ectopic expression of Derlin‐1 promotes breast cancer cell proliferation and migration, whereas the knockdown of Derlin‐1 results in the opposite phenotypes. Mechanistically, Derlin‐1 directly binds to UBE2C to increase the phosphorylation of AKT and ERK. The treatment of UBE2C siRNA markedly attenuates Derlin‐1‐mediated cell growth and migration. Collectively, our data suggest Derlin‐1 is a potential prognostic factor and functions as an oncogene in breast cancer.
Patient‐rated impulsivity and aggression compared with clinician‐rated risk in a forensic psychiatric sample: Predicting inpatient incidents
Authors: Karsten Julie , Akkerman‐Bouwsema Gerjonne J. , Hagenauw Loes A. , Gerlsma Coby , Lancel Marike 
Published: October 2019

AbstractBackgroundMeasures of impulsivity and aggression help to indicate risk of future violence or rule‐breaking. Both clinician‐rated risk assessment and self‐report measures have been used but hardly ever compared in their ability to predict inpatient incidents.AimsTo compare the self‐report on the Barratt Impulsiveness Scale (BIS‐11) and Buss‐Perry Aggression Questionnaire (BPAQ) with the clinician‐rated HKT‐30, a Dutch adaptation of the Historical Clinical Risk Management‐20, for their capacity to predict inpatient incidents.MethodsAll men newly admitted to a forensic psychiatric hospital were invited to participate in this study unless in intensive care. Tests of correlation were run between the BIS‐11 and BPAQ scale scores and the HKT‐30. Each was then tested separately for capacity to predict the number of aggressive and nonaggressive incidents while resident. Finally, scores of all rating scales were entered together into a negative binomial regression to compare their relative strengths in predicting later incidents.ResultsPatient and staff baseline impulsivity and aggression ratings correlated moderately well. All measures performed well in univariate analyses of relationship between baseline measures and later incidents. In final models, which included both patient and staff baseline ratings, the HKT‐30 generally outperformed the self‐report measures in the prediction of aggressive and nonaggressive incidents in both the first year and total length of stay.Implications for clinical practiceOur findings suggest that some reliance may be placed on patient ratings of their own propensity for impulsive and/or violent acts, but, when used, they should remain combined with clinician‐rated risk assessment for the time being. Future research should explore their utility in dialogue about treatment, and also the relative strength of staff response to each.
Filling in the gaps: Implantable bronchial valves in pediatric patients with persistent leaks
Authors: Kuranga Abraham O. , Hysinger Erik B. , Caudell Stamper Danielle , Benzaquen Sadia 
Published: October 2019

AbstractThis series presents an adult procedure that benefits young patients with persistent air leaks. This less invasive procedure can be done outpatient with adult/pediatric bronchoscopists providing patients less invasive procedures with better outcomes.
Simultaneous Spin‐Crossover Transition and Conductivity Switching in a Dinuclear Iron(II) Coordination Compound Based on 7,7′,8,8′‐Tetracyano‐p‐quinodimethane
Authors: Ishikawa Ryuta , Ueno Shuya , Nifuku Shoei , Horii Yoji , Iguchi Hiroaki , Miyazaki Yuji , Nakano Motohiro , Hayami Shinya , Kumagai Shohei , Katoh Keiichi , Li Zhao‐Yang , Yamashita Masahiro , Kawata Satoshi 
Published: October 2019

AbstractThe reaction of Fe(OAc)2 and Hbpypz with neutral TCNQ results in the formation of [Fe2(bpypz)2(TCNQ)2](TCNQ)2 (1), in which Hbpypz=3,5‐bis(2‐pyridyl)pyrazole and TCNQ=7,7′,8,8′‐tetracyano‐p‐quinodimethane. Crystal packing of 1 with uncoordinated TCNQ and π–π stacking of bpypz− ligands produces an extended two‐dimensional supramolecular coordination assembly. Temperature dependence of the dc magnetic susceptibility and heat capacity measurements indicate that 1 undergoes an abrupt spin crossover (SCO) with thermal spin transition temperatures of 339 and 337 K for the heating and cooling modes, respectively, resulting in a thermal hysteresis of 2 K. Remarkably, the temperature dependence of dc electrical transport exhibits a transition that coincides with thermal SCO, demonstrating the thermally induced magnetic and electrical bistability of 1, strongly correlating magnetism with electrical conductivity. This outstanding feature leads to thermally induced simultaneous switching of magnetism and electrical conductivity and a magnetoresistance effect.
Polymorphous Luminescent Materials Based on ′T′‐Shaped Molecules Bearing 4,7‐Diphenylbenzo[c][1,2,5]thiadiazole Skeletons: Effect of Substituents on the Photophysical Properties
Authors: Qian Gaowei , Wang Xiangbing , Wang Shengyue , Zheng Yanqiong , Wang Song , Zhu Weiguo , Wang Yafei 
Published: October 2019

AbstractPolymorphism, the intrinsic character of one chemical compound with at least two distinct phase arrangements, plays a very key role in the photophysical properties. In this contribution, four ′T′‐shaped molecules bearing the 2,1,3‐benzothiadiazole (BTD) skeleton, named 5 a–5 d, were prepared and characterized. All compounds exhibited excellent thermal stability and polymorphism in the solid state, evident from thermogravimetric analysis, differential scanning calorimetry, and polarized optical microscopy results. Intense emissions with high photoluminescent quantum yields were achieved both in solution (56–97 %) and neat films (33–98 %). All compounds possessed clearly pH‐dependent luminescence properties in solution. Additionally, compound 5 d showed useful mechanochromic luminescence owing to the transformation between the crystal and amorphous state. Employing compounds 5 a–5 d as the dopant, solution‐processable organic light‐emitting diodes (OLEDs) were fabricated and presented a highest external quantum efficiency of 6.15 %, which is higher than the theoretical value of fluorescence‐based OLEDs (∼5 %). This research provided a novel strategy for designing high‐efficiency BTD‐based polymorphic luminescent materials.
The Nargenicin Family of Oxa‐Bridged Macrolide Antibiotics
Authors: Pidot Sacha J. , Rizzacasa Mark A. 
Published: October 2019

AbstractThe nargenicin family of antibiotic macrolides comprise a group of bacterial natural products with a rare ether bridged cis‐decalin moiety and a narrow spectrum of activity. Most family members were identified almost four decades ago and were placed on the shelf due to the numbers of broad‐spectrum compounds available at the time. However, in light of rising rates of antimicrobial resistance, there has been a renewed interest in the use of narrow‐spectrum antimicrobials. Here, we review the history of this family of compounds, including synthetic approaches, and highlight the recently uncovered genetic basis for nargenicin production. Given the renewed pharmaceutical interest in these compounds, we also investigate structure–activity relationships among these molecules, with a view to the future development of members of this unusual antibiotic family.
Untying the Photophysics of Quinolinium‐Based Molecular Knots and Links
Authors: Caprice Kenji , Aster Alexander , Cougnon Fabien B. L. , Kumpulainen Tatu 
Published: October 2019

AbstractComplex molecular knots and links are still difficult to synthesize and the properties arising from their topology are mostly unknown. Here, we report on a comparative photophysical study carried out on a family of closely related quinolinium‐based knots and links to determine the impact exerted by topology on the molecular backbone. Our results indicate that topology has a negligible influence on the behavior of loosely braided molecules, which mostly behave like their unbraided equivalents. On the other hand, tightly braided molecules display distinct features. Their higher packing density results in a pronounced ability to resist deformation, a significant reduction in the solvent‐accessible surface area and favors close‐range π–π interactions between the quinolinium units and neighboring aromatics. Finally, the sharp alteration in behavior between loosely and tightly braided molecules sheds light on the factors contributing to braiding tightness.
Characteristics of as‐prepared biochar derived from catalytic pyrolysis within moderate‐temperature ionic liquid for CO2 uptake
Authors: Du Yarong , Fan Zeng , Guo Tianxiang , Xu Junpeng , Han Zhonghe , Pan Yuanfeng , Xiao Huining , Sun Yiming , Yan Qingqi 
Published: October 2019

AbstractA promising biochar as solid adsorbent for CO2 uptake was prepared by the catalytic pyrolysis of coconut shell in moderate‐temperature ionic liquid (IL). Then, it was characterized by means of SEM, EDS, BPEA, BET, NLDFT, FTIR, and TG‐DSC, and a mechanism interpretation of the porous biochar formation was conducted. In addition, the adsorption characteristics of CO2 on the as‐prepared biochar, such as adsorption capacity, adsorption potential, isosteric heat, and static selectivity at different adsorption temperatures and pressures, were systematically evaluated. The results indicated that the as‐prepared biochar exhibited an adequate CO2 adsorption with a capacity of 4.5 mmol/g at 273 K and 100 kPa. Then, a significant number of slit‐like pores were revealed to exist on the as‐prepared biochar with a peak pore size between a range of 0.6 nm‐2 nm. The porous structure formation was ascribed to the release of carbon‐, hydrogen‐, oxygen‐, sulphur‐, and nitrogen‐containing compounds during biochar preparation. Meanwhile, both the adsorption potential and isosteric heat of the CO2 uptake under the tested conditions decreased with an increase in the adsorption capacity, which ranged from 33 kJ/mol‐21 kJ/mol and 23 kJ/mol‐7 kJ/mol, respectively. Therefore, the isosteric heat could be considered as a piecewise function of adsorption capacity. In addition, the molar ratios of CO2 over N2 adsorbed under the tested conditions were above 11 and were accompanied by molar ratio peaks of 26 at 273 K and 19 at 298 K, respectively. Moreover, an interesting phenomenon occurred: the static adsorptive selectivity of CO2 over N2 first increased and then decreased and there was an increase in the adsorption pressure at the tested adsorption temperatures.
The evaluation of customer experience using BP neural network‐taking catering O2O takeout
Authors: Pei Yi‐Lei , Li Dan‐Dan , Xue Wan‐Xin 
Published: October 2019

SummaryIn China, catering O2O takeout develops rapidly; thus, there is the fierce competition in the catering O2O industry. More and more catering O2O takeout platforms focus on customer experience, especially service experience in distribution link, so it is extremely necessary to evaluate customer experience of catering O2O takeout in China scientifically and reasonably. This paper establishes a customer experience evaluation index system from the perspectives of O2O takeout platform, delivery staff, and distribution process. This paper uses the BP Neural Network Model to evaluate customer experience of catering O2O takeout, uses Principal Component Analysis to extract principal components as the input of BP neural network model, and uses the model of MATLAB Neural Network Toolbox to conduct the training simulation with customer experience data. The results show that the model can evaluate customer experience of catering O2O takeout. The analysis in this paper provides a new evaluation method of customer experience for catering O2O takeout in China.
Type of delivery and reading, writing, and arithmetic learning in twin births
Authors: González‐Valenzuela María‐José , López‐Montiel Dolores , Cazorla‐Granados Olga , González‐Mesa Ernesto 
Published: November 2019

AbstractThis study analyses, in children born in twin births, the relationship between reading, writing and arithmetic learning, on the one hand, and type of delivery, on the other, controlling for the effect of interaction and/or confusion of third variables (maternal age at delivery, gestational age, fetal position, birthweight, 1‐min Apgar score). In the planned retrospective cohort design, the exposed cohort consisted of children born by caesarean section, and the non‐exposed cohort was comprised of children born vaginally. One hundred and twenty‐four children born of twin births were evaluated during their first year of primary school: K‐BIT tests were used to measure intelligence; the Evalúa‐1 battery was used to assess reading, writing, and arithmetic ability; and the children's clinical histories were analysed for obstetric and neonatal variables. After applying binary logistic regressions for each dependent variable, it was found that caesarean delivery in twin births appeared as a possible independent risk factor for specific learning disabilities (LDs) in reading, writing, and arithmetic. Based on these results, further research using larger samples and at more advanced ages is required in order to analyse the influence of obstetric and neonatal variables on the processes underlying specific LDs.
The occurrence of putative cognitive enhancing research peptides in seized pharmaceutical preparations: An incentive for controlling agencies to prepare for future encounters of the kind
Authors: Vanhee Celine , Francotte Antoine , Janvier Steven , Deconinck Eric 
Published: October 2019

AbstractAt the end of 2017 and 2018 two different unknown suspicious preparations were encountered and were subjected to a plethora of different analyses in order to identify, if present, any bioactive compound. It turned out that these samples contained the assumedly cognitive enhancing research peptides Selank and Semax, which, to our knowledge, have not completed any clinical trials. Moreover, an online search, excluding the dark web, demonstrated that these kinds of nootropic research peptides are freely available either as lyophilized powder for injection purposes or are present in nasal sprays. It stands to reason that controlling laboratories need to anticipate the uprising of these types of potentially dangerous molecules and must therefore be able to correctly identify these compounds. Therefore, these findings served as an incentive to develop a novel combined liquid chromatography tandem mass spectroscopy (LC–MS/MS) methodology, applicable to both hydrophilic or more hydrophobic peptides, which was utilized to analyze a total of 10 putative cognitive enhancing polypeptides, with variable biochemical characteristics, that are currently being sold online. The screening rationale, complying to the recommendation paper of the General European Official Medicines Control Laboratory (OMCL) network on the interpretation of screening results for unknown peptides by mass spectrometry, was also validated in different matrices as required by ISO 17025.
Reduced sexual size dimorphism in a pipefish population where males do not prefer larger females
Authors: Cunha Mário , Macedo Nídia , Wilson Jonathan , Rosenqvist Gunilla , Berglund Anders , Monteiro Nuno 
Published: November 2019

AbstractWithin a species' distribution, populations are often exposed to diverse environments and may thus experience different sources of both natural and sexual selection. These differences are likely to impact the balance between costs and benefits to individuals seeking reproduction, thus entailing evolutionary repercussions. Here, we look into an unusual population (Baltic Sea) of the broadnosed pipefish, Syngnathus typhle, where males do not seem to select females based on size and hypothesize that this pattern may derive from a reduction in direct benefits to the male. We further hypothesize that if larger females do not persistently secure a higher reproductive success, either through pre‐ or postcopulatory sexual selection, a decrease in sexual size dimorphism in the Baltic population should be apparent, especially when contrasted with a well‐studied population, inhabiting similar latitudes (Swedish west coast), where males prefer larger females. We found that, in the Baltic population, variation in female quality is low. We were unable to find differences in abortion rates or protein concentration in oocytes produced by females of contrasting sizes. Direct benefits from mating with large partners seem, thus, reduced in the Baltic population. We also found no evidence of any postcopulatory mechanism that could favor larger mothers as embryo development was unrelated to female size. While female size can still be selected through intrasexual competition or fecundity selection, the pressure for large female body size seems to be lower in the Baltic. Accordingly, we found a noticeable decrease in sexual size dimorphism in the Baltic population. We conclude that, although far from negating the significance of other selective processes, sexual selection seems to have a decisive role in supporting pipefish sexual size asymmetries.
The ecology of suburban juvenile European hedgehogs (Erinaceus europaeus) in Denmark
Authors: Rasmussen Sophie L. , Berg Thomas B. , Dabelsteen Torben , Jones Owen R. 
Published: October 2019

Abstract

European hedgehog (Erinaceus europaeus) populations are widespread across diverse habitats but are declining in Western Europe. Drastic declines have been described in the UK, with the most severe declines occurring in rural areas. Hedgehogs are widely distributed in Denmark, but their status remains unknown.

Fieldwork on hedgehogs has tended to focus on rural areas, leaving their ecology in suburban habitats largely unexplored, with clear implications for conservation initiatives. Here, we study the ecology of 35 juvenile hedgehogs using radio tracking during their first year of life in the suburbs of western Copenhagen.

We use radio‐tracking data to estimate (a) home range sizes in autumn and spring/summer, (b) survival during their first year of life, (c) the body mass changes before, during, and after hibernation, and (d) the hibernation behavior of the juvenile hedgehogs.

We show that males and females have small home ranges compared with previous studies. The 95% MCP home range sizes in autumn were 1.33 ha (95% CI = 0.88–2.00) for males and 1.40 ha (95% CI = 0.84–2.32) for females; for spring/summer they were 6.54 ha (95% CI = 3.76–11.38) for males and 1.51 ha (95% CI = 0.63–3.63) for females. The juvenile survival probabilities during the study period from September 2014 to July 2015 were .56 for females and .79 for males. All healthy individuals gained body mass during the autumn and survived hibernation with little body mass loss thus demonstrating that the juveniles in the study were capable of gaining sufficient weight in the wild to survive their first hibernation.

The climate is changing, but there is a lack of knowledge on how this affects mammal ecology. The exceptionally mild autumn of 2014 caused the juvenile hedgehogs to delay hibernation for up to a month compared with previous studies in Denmark.
Environmental DNA monitoring for short‐term reproductive migration of endemic anadromous species, Shishamo smelt (Spirinchus lanceolatus)
Authors: Yatsuyanagi Tetsu , Ishida Ryotaro , Sakata Masayuki K. , Kanbe Takashi , Mizumoto Hiroki , Kobayashi Yumi , Kamada Shoko , Namba Satoko , Nii Hisaya , Minamoto Toshifumi , Araki Hitoshi 
Published: November 2019

AbstractMonitoring reproductive migration is essential for the conservation of anadromous species. Shishamo smelt (Spirinchus lanceolatus) is endemic to Hokkaido, the northernmost large island in Japan. S. lanceolatus is an anadromous species that is known to migrate into rivers for a very short period in early winter. While this species has a special value for local fisheries, the catch amount has drastically declined in the last few decades. Information about S. lanceolatus reproductive migration dynamics is limited, which prevents them from being efficiently managed as a resource. In this study, we used environmental DNA (eDNA) methods as a noninvasive molecular tool for estimating presence/absence and abundance/biomass of S. lanceolatus during their migration into rivers. We developed a species‐specific qPCR system for S. lanceolatus, examining (a) temporal variation in S. lanceolatus eDNA concentrations compared with catch data gathered by traditional methods and (b) variability of migratory patterns among river systems. In a core river for their spawning migration, we consistently detected S. lanceolatus eDNA throughout the spawning season, and the temporal distribution of eDNA concentration was consistent with that of the number of migrating S. lanceolatus estimated by catch survey data. In addition, we were able to detect S. lanceolatus eDNA even from rivers without any official record of their migration. Among rivers with eDNA detection, the relative eDNA concentrations varied, indicating that the population biomass differs largely among the river populations. Our study suggests that eDNA detection systems are useful for tracking reproductive migration of S. lanceolatus at fine spatio‐temporal scales.
Spatial correlations of ground motion for non‐ergodic seismic hazard analysis
Authors: Kuehn Nicolas M. , Abrahamson Norman A. 
Published: October 2019

SummaryTraditional probabilistic seismic hazard analysis (PSHA) uses ground‐motion models that are based on the ergodic assumption, which means that the distribution of ground motions over time at a given site is the same as their spatial distribution over different sites. Evaluations of ground‐motion data sets with multiple measurements at a given site and multiple earthquakes in a given region have shown that the ergodic assumption is not appropriate as there are strong systematic region‐specific source terms and site‐specific path and site terms that are spatially correlated. We model these correlations using a spatial Gaussian process model. Different correlations functions are employed, both stationary and non‐stationary, and the results are compared in terms of their predictive power. Spatial correlations of residuals are investigated on a Taiwanese strong‐motion data set, and ground motions are collected at the ANZA, CA array. Source effects are spatially correlated, but provide a much stronger benefit in terms of prediction for the ANZA data set than for the Taiwanese data set. We find that systematic path effects are best modeled by a non‐stationary covariance function that is dependent on source‐to‐site distance and magnitude. The correlation structure estimated from Californian data can be transferred to Taiwan if one carefully accounts for differences in magnitudes. About 50% of aleatory variance can be explained by accounting for spatial correlation.