bluuebunny/crossref_metadata_2025_split huggingface dataset:
Which cues influence the perceived usefulness and credibility of an online review? A conjoint analysis
Authors: Lopes Ana Isabel , Dens Nathalie , De Pelsmacker Patrick , De Keyzer Freya 
Published: November 2020

PurposeThis study aims to assess the relative importance of the argument strength, argument sidedness, writing quality, number of arguments, rated review usefulness, summary review rating and number of reviews in determining the perceived usefulness and credibility of an online review. Additionally, the authors use insights from the elaboration likelihood model (ELM) to explore the effect of consumers' product category involvement on the cues' relative importance.Design/methodology/approachA conjoint analysis (N = 287) is used to study the relative importance of the seven previously mentioned attributes. A balanced orthogonal design generated eight cards that correspond to individual reviews. Respondents scored all eight cards in a random order for perceived usefulness and credibility.FindingsOverall, argument strength is the most important cue, while summary review rating and the number of reviews are the least important for perceived review usefulness and credibility. The number of arguments is more important for people who are more highly involved with the product, while writing quality and rated review usefulness are relatively more important for the low-involvement group.Originality/valueThis study provides a comprehensive test of how consumers perceive online reviews, as it the first to the authors’ knowledge to simultaneously investigate a large set of cues using conjoint analysis. This method allows for the implicit valuation (utility) of the individual cues, revealing the cues' relative importance, in a setting that comes close to a real-life context. Besides, insights of the ELM are used to understand how the relative importance of cues differs depending on the level of review readers' product category involvement.
Cervical dilatation and preparation prior to outpatient hysteroscopy: a systematic review and meta‐analysis
Authors: De Silva PM , Wilson L , Carnegy A , Smith PP , Clark TJ 
Published: November 2020

BackgroundThere are uncertainties about the benefit of routine cervical preparation and/or cervical dilatation before outpatient hysteroscopy.ObjectiveTo determine if cervical preparation and/or routine mechanical dilatation reduces pain during outpatient hysteroscopy.Search strategyMEDLINE, EMBASE, CINAHL and CENTRAL were searched on 19 October 2020, using keywords ‘hysteroscopy’, ‘cervical preparation’, ‘cervical ripening’, ‘cervical dilatation’, ‘outpatient’, ‘office’ and/or ‘ambulatory’ and associated medical subject headings.Selection criteriaRandomised controlled trials investigating the benefit of cervical preparation and/or cervical dilatation on pain in women undergoing outpatient hysteroscopy were included.Data collection and analysisTwo independent reviewers selected eligible trials and extracted data on pain, feasibility, adverse events and satisfaction/acceptability for meta‐analysis.Main resultsThe literature search yielded 807 records, of which 24 were included for review and 19 provided data for meta‐analysis. No trials investigated the role of routine mechanical cervical dilatation. Cervical preparation significantly reduced pain during outpatient hysteroscopy; standard mean difference (SMD) ‒0.67, 95% confidence interval (CI) ‒1.05 to ‒0.29. Feasibility also improved as priming provided significantly easier hysteroscopic entry (SMD 0.89, 95% CI 0.32–1.46), greater cervical dilatation (SMD 0.81, 95% CI 0.08–1.53) and shorter procedural times (SMD ‒0.51, 95% CI ‒0.88 to ‒0.13). Cervical preparation, however, incurred significantly more adverse effects, mainly comprising genital tract bleeding, abdominal pain and gastrointestinal symptoms (odds ratio 2.94, 95% CI 1.58–5.47). There were limited data regarding satisfaction, acceptability and complications.ConclusionsCervical preparation reduces pain and improves feasibility associated with outpatient hysteroscopy but increases the risk of adverse effects.Tweetable abstractCervical preparation before outpatient hysteroscopy reduces pain, enhances feasibility but increases adverse effects.
PPARγ agonists delay age‐associated metabolic disease and extend longevity
Authors: Xu Lingyan , Ma Xinran , Verma Narendra , Perie Luce , Pendse Jay , Shamloo Sama , Marie Josephson Anne , Wang Dongmei , Qiu Jin , Guo Mingwei , Ping Xiaodan , Allen Michele , Noguchi Audrey , Springer Danielle , Shen Fei , Liu Caizhi , Zhang Shiwei , Li Lingyu , Li Jin , Xiao Junjie , Lu Jian , Du Zhenyu , Luo Jian , Aleman Jose O. , Leucht Philipp , Mueller Elisabetta 
Published: November 2020

AbstractAging leads to a number of disorders caused by cellular senescence, tissue damage, and organ dysfunction. It has been reported that anti‐inflammatory and insulin‐sensitizing compounds delay, or reverse, the aging process and prevent metabolic disorders, neurodegenerative disease, and muscle atrophy, improving healthspan and extending lifespan. Here we investigated the effects of PPARγ agonists in preventing aging and increasing longevity, given their known properties in lowering inflammation and decreasing glycemia. Our molecular and physiological studies show that long‐term treatment of mice at 14 months of age with low doses of the PPARγ ligand rosiglitazone (Rosi) improved glucose metabolism and mitochondrial functionality. These effects were associated with decreased inflammation and reduced tissue atrophy, improved cognitive function, and diminished anxiety‐ and depression‐like conditions, without any adverse effects on cardiac and skeletal functionality. Furthermore, Rosi treatment of mice started when they were 14 months old was associated with lifespan extension. A retrospective analysis of the effects of the PPARγ agonist pioglitazone (Pio) on longevity showed decreased mortality in patients receiving Pio compared to those receiving a PPARγ‐independent insulin secretagogue glimepiride. Taken together, these data suggest the possibility of using PPARγ agonists to promote healthy aging and extend lifespan.
Heterogeneities in administration methods among cannabis users by use purpose and state legalization status: findings from a nationally representative survey in the United States, 2020
Authors: Shi Yuyan 
Published: November 2020

AbstractBackground and AimsDifferent cannabis administration methods have differential impacts on health. This study aimed to describe administration methods among cannabis users in the United States categorized by (1) use purpose and (2) state legalization status.DesignCross‐sectional, probability‐based online survey in 2020.SettingAll 50 states and Washington DC in the United States.ParticipantsA total of 21 903 adults (18+) were recruited from a probability‐based online panel to provide nationally representative estimates.MethodsEleven administration methods were grouped into combustion, vaporization, ingestion and topicals. Weighted prevalence was reported among (1) medical‐only, recreational‐only and dual‐purpose users based on self‐reported purposes and (2) users in states that legalized both recreational and medical cannabis (RCL states), legalized medical cannabis only and did not legalize cannabis.FindingsAmong past‐year users, the proportions of medical‐only, recreational‐only and dual‐purpose users were 25.55, 43.81 and 30.64%, respectively. The most common primary methods were combustion (42.08%) and topicals (28.65%) for medical purposes and combustion (72.07%) and ingestion (15.05%) for recreational purposes. Dual‐purpose users were more likely to report combustion and vaporization but less likely to report ingestion and topicals as primary methods for medical use than medical‐only users (P < 0.001) and more likely to report combustion and topicals but less likely to report ingestion as primary methods for recreational use than recreational‐only users (P < 0.041). A higher proportion of dual‐purpose users (82.82%) used more than one method than medical‐only (40.52%) and recreational‐only users (63.91%) (P < 0.001). For both medical and recreational purposes, RCL states had the lowest rate of combustion and the highest rates of ingestion and topicals reported as primary methods (P < 0.033). The rate of using more than one administration method did not differ across states (P > 0.05).ConclusionCannabis users whose purposes are medical, recreational or both tend to differ in their selected administration methods.
Effectiveness of training stop‐smoking advisers to deliver cessation support to the UK national proposed standard versus usual care in Malaysia: a two‐arm cluster‐randomized controlled trial
Authors: Wee Lei Hum , West Robert , Tee Guat Hiong , Yeap Lena , Chan Caryn Mei Hsien , Ho Bee Kiau , Perialathan Komathi , Nik Mohamed Mohamad Haniki , Michie Susan , Jackson Sarah E. 
Published: November 2020

AbstractAimsTo assess the effectiveness of training stop smoking services providers in Malaysia to deliver support for smoking cessation based on the UK National Centre for Smoking Cessation and Training (NCSCT) standard treatment programme compared with usual care.DesignTwo‐arm cluster‐randomized controlled effectiveness trial across 19 sites with follow‐up at 4‐week, 3‐month, and 6‐month.SettingStop smoking services operating in public hospitals in Malaysia.ParticipantsFive hundred and two smokers [mean ± standard deviation (SD), age 45.6 (13.4) years; 97.4% male] attending stop smoking services in hospital settings in Malaysia: 330 in 10 hospitals in the intervention condition and 172 in nine hospitals in the control condition.Intervention and comparatorThe intervention consisted of training stop‐smoking practitioners to deliver support and follow‐up according to the NCSCT Standard Treatment Programme. The comparator was usual care (brief support and follow‐up).MeasurementsThe primary outcome was continuous tobacco smoking abstinence up to 6 months in smokers who received smoking cessation treatment, verified by expired‐air carbon monoxide (CO) concentration. Secondary outcomes were continuous CO‐verified tobacco smoking abstinence up to 4 weeks and 3 months.ResultsFollow‐up rates at 4 weeks, 3 months and 6 months were 80.0, 70.6 and 53.3%, respectively, in the intervention group and 48.8, 30.8 and 23.3%, respectively, in the control group. At 6‐month follow‐up, 93 participants in the intervention group and 19 participants in the control group were abstinent from smoking, representing 28.2 versus 11.0% in an intention‐to‐treat (ITT) analysis assuming that participants with missing data had resumed smoking, and 52.8 versus 47.5% in a follow‐up‐only (FUO) analysis. Unadjusted odds ratios (accounting for clustering) were 5.04, (95% confidence interval (CI) = 1.22–20.77, P = 0.025) and 1.70, (95% CI = 0.25–11.53, P = 0.589) in the ITT and FUO analyses, respectively. Abstinence rates at 4 week and 3 month follow‐ups were significantly higher in the intervention versus control group in the ITT but not the FUO analysis.ConclusionsOn an intention‐to‐treat analysis with missing‐equals‐smoking imputation, training Malaysian stop smoking service providers in the UK National Centre for Smoking Cessation and Training standard treatment programme appeared to increase 6 month continuous abstinence rates in smokers seeking help with stopping compared with usual care. However, the effect may have been due to increasing follow‐up rates.
Seminal human papillomavirus infection and reproduction: a systematic review and meta‐analysis
Authors: Moreno‐Sepulveda Jose , Rajmil Osvaldo 
Published: November 2020

AbstractBackgroundThe impact of human papillomavirus (HPV) on male fertility and associated reproductive outcomes has not been clarified.ObjectivesTo elucidate the prevalence of seminal HPV infection and assess the associated effects on seminal parameters, male infertility, and reproductive outcomes.Materials and methodsA systematic review and meta‐analysis was performed in accordance with PRISMA guidelines. A search was performed using PubMed, MEDLINE, SCOPUS, and Cochrane databases. Studies published until November 2019 were included. HPV prevalence, risk of infertility, seminal parameters, and reproductive outcomes were evaluated among the general population and infertile men.ResultsFifty studies met the inclusion criteria. The prevalence of seminal HPV infection is significantly higher in infertile compared to the general population (20.9% versus 8.2%). A significant association between seminal HPV infection and male infertility (OR 3.30, 95% CI 1.87–5.84), even when adjusting for female infertility (OR 3.02, 95% CI = 2.11–4.33) was founded. In addition, HPV infection is related to a significant decrease in progressive motility (DM −10.35, IC −13.75, −6.96), a low sperm morphology score (DM −2.46, 95% CI −3.83, −1.08), and a significant increase in the sperm DNA fragmentation index (7.24, 95% CI 4.44.10.03) compared with HPV‐negative patients. It was also observed an increased risk of miscarriage (OR 5.13, 95% CI 2.40,10.94), and a reduced chance of ongoing pregnancy (OR 0.33, IC 95% 0.13,0,82) in patients undergoing ART with seminal HPV infection.DiscussionInfertile men have a higher prevalence of seminal HPV infection compared to the general population, regardless of the HPV genotype detected.ConclusionsHPV in semen may have an impact in sperm quality and reproductive outcomes. Additional well‐designed studies are warranted to improve the quality of evidence.
Usability and acceptability of a multimodal respiratory rate and pulse oximeter device in case management of children with symptoms of pneumonia: A cross‐sectional study in Ethiopia
Authors: Baker Kevin , Ward Charlotte , Maurel Alice , de Cola Monica Anna , Smith Helen , Getachew Dawit , Habte Tedila , McWhorter Cindy , LaBarre Paul , Karlstrom Jonas , Ameha Agazi , Tariku Abraham , Black Jim , Bassat Quique , Källander Karin 
Published: November 2020

AbstractAimPneumonia is the leading infectious cause of death among children under five globally. Many pneumonia deaths result from inappropriate treatment due to misdiagnosis of signs and symptoms. This study aims to identify whether health extension workers (HEWs) in Ethiopia, using an automated multimodal device (Masimo Rad‐G), adhere to required guidelines while assessing and classifying under five children with cough or difficulty breathing and to understand device acceptability.MethodsA cross‐sectional study was conducted in three districts of Southern Nations, Nationalities, and Peoples' Region, Ethiopia. Between September and December 2018, 133 HEWs were directly observed using Rad‐G while conducting 599 sick child consultations. Usability was measured as adherence to the World Health Organization requirements to assess fast breathing and device manufacturer instructions for use. Acceptability was assessed using semi‐structured interviews with HEWs, first‐level health facility workers and caregivers.ResultsAdherence using the Rad‐G routinely for 2 months was 85.3% (95% CI 80.2, 89.3). Health workers and caregivers stated a preference for Rad‐G. Users highlighted a number of device design issues.ConclusionWhile demonstrating high levels of acceptability and usability, the device modifications to consider include better probe fit, improved user interface with exclusive age categories and simplified classification outcomes.
Spatial extent and severity of all‐terrain vehicles use on coastal sand dune vegetation
Authors: Hogan Jessica L. , Brown Carissa D. 
Published: November 2020

AbstractQuestionsIncreases in all‐terrain vehicle (ATV) use on dunes raises concerns about an ecosystem vital for coastal protection. We asked: with distance from trails, what are the effects of ATV use on (a) total, native, and non‐native plant species richness and (b) presence and cover of the dune‐stabilising plant Ammophila breviligulata? Specifically, how do (a) and (b) differ (1) between regions with and without ATV use; (2) with deeper ruts and increased distance from the ATV trail; and (3) between pioneer and shrub zones of dunes in each region?LocationMiscou Island and Kouchibouguac National Park, New Brunswick, Canada.MethodsWe assessed ATV effects by conducting field vegetation surveys in a region with (Miscou Island) and without (Kouchibouguac National Park) ATV use. Line transects were used to capture gradients of effects across the dune community via plots evenly placed to measure trail effects (on the trail), close‐edge effects (edge of the trail), and distant‐edge effects (every 5 m up to 25 m away from trail), in pioneer and shrub zones of dunes.ResultsAll‐terrain vehicle rut depth was associated with a decrease in total and native species on the trails and on the edge of trails, and with a slight increase in non‐native species beyond the trail edge. We also found a rut depth threshold of approximately 50 cm, beyond which was an abrupt decline across all species. Where ATV activity occurred, there was also a decrease of A. breviligulata in presence and cover, non‐native species increased in the pioneer zone, and the shrub zone had fewer native species.ConclusionsAll‐terrain vehicle use plays a major role in the vegetation changes observed on coastal dunes. A management plan that recognises the specific effects caused by ATV use on dune vegetation will help preserve dunes, enabling more cost‐effective coastal protection than engineered interventions.
TEOS: A framework for constructing operational definitions of medication adherence based on Timelines–Events–Objectives–Sources
Authors: Dima Alexandra L. , Allemann Samuel S. , Dunbar‐Jacob Jacqueline , Hughes Dyfrig A. , Vrijens Bernard , Wilson Ira B. 
Published: November 2020

AimsManaging adherence to medications is a priority for health systems worldwide. Adherence research is accumulating, yet the quality of the evidence is reduced by various methodological limitations. In particular, the heterogeneity and low accuracy of adherence measures have been highlighted in many literature reviews. Recent consensus‐based guidelines advise on best practices in defining adherence (ABC) and reporting of empirical studies (EMERGE). While these guidelines highlight the importance of operational definitions in adherence measurement, such definitions are rarely included in study reports. To support researchers in their measurement decisions, we developed a structured approach to formulate operational definitions of adherence.MethodsA group of adherence and research methodology experts used theoretical, methodological and practical considerations to examine the process of applying adherence definitions to various research settings, questions and data sources. Consensus was reached through iterative review of discussion summaries and framework versions.ResultsWe introduce TEOS, a four‐component framework to guide the operationalization of adherence concepts: (1) describe treatment as four simultaneous interdependent timelines (recommended and actual use, conditional on prescribing and dispensing); (2) locate four key events along these timelines to delimit the three ABC phases (first and last recommended use, first and last actual use); (3) revisit study objectives and design to fine‐tune research questions and assess measurement validity and reliability needs, and (4) select data sources (e.g., electronic monitoring, self‐report, electronic healthcare databases) that best address measurement needs.ConclusionUsing the TEOS framework when designing research and reporting explicitly on these components can improve measurement quality.
Two tagging single‐nucleotide polymorphisms to captureHLA‐DRB1*07:01–DQA1*02:01–DQB1*02:02haplotype associated with asparaginase hypersensitivity
Authors: Kutszegi Nóra , Gézsi András , F. Semsei Ágnes , Müller Judit , Simon Réka , Kovács Erika Rozália , Hegedüs Katalin , Kovács Gábor T. , Szalai Csaba , Erdélyi Dániel J. 
Published: November 2020

AimsAsparaginase (ASP) hypersensitivity is a well‐known challenge in the treatment of lymphoblastic malignancies. In terms of cost considerations, the cheap nativeEscherichia coliASP, the most immunogenic form of this medication, is used in the first line in middle‐income countries. Previously, the role of theHLA‐DRB1*07:01–DQA1*02:01–DQB1*02:02haplotype had been established to associate withE. coliASP hypersensitivity. We investigated a possible cost‐effective genetic testing method to identify patients harbouring the risk HLA haplotype in order to pave the way for safer ASP treatment.MethodsIn 241 patients with previously determinedHLA‐DRB1*07:01–DQA1*02:01–DQB1*02:02haplotype and known ASP hypersensitivity status, 4 candidate HLA‐tagging single‐nucleotide polymorphisms (SNP)s were measured, and the performance of the different sets of these tag SNPs was evaluated.ResultsWe identified a combination of 2 SNPs — rs28383172 and rs7775228 — as a tag forHLA‐DRB1*07:01–DQA1*02:01–DQB1*02:02haplotype with sensitivity and specificity values >95%. In line with previous findings, we found complete concordance betweenHLA‐DRB1*07:01and rs28383172. With bioinformatics methods, the results were also confirmed in the 1000 Genomes dataset in different ethnic groups.ConclusionRs28383172 and rs7775228 are suitable for identifyingHLA‐DRB1*07:01–DQA1*02:01–DQB1*02:02carriers. Compared to the rest of the population, patients with hypersensitivity‐prone genotype would benefit more from the administration of less immunogenic PEGylated ASP before the hypersensitivity evolves, incurring minimal extra cost.
Pharmacometric analyses to characterize the effect of CSL112 on apolipoprotein A‐I and cholesterol efflux capacity in acute myocardial infarction patients
Authors: Zheng Bo , Duffy Danielle , Tricoci Pierluigi , Kastrissios Helen , Pfister Marc , Wright Samuel D. , Gille Andreas , Tortorici Michael A. 
Published: November 2020

AimsTo characterize relationships between apolipoprotein A‐I (apoA‐I) exposure and cholesterol efflux capacity (CEC) and covariate effects following CSL112 (apoA‐I [human]) administration in an integrated population including acute myocardial infarction (AMI) patients.MethodsA pharmacometric analysis utilized data from seven clinical trials, including patients with AMI, subjects with renal impairment and healthy subjects. A population pharmacokinetic (PK) analysis was performed to relate CSL112 doses to changes in apoA‐I plasma concentrations. Covariate analysis was conducted to identify sources of variability in apoA‐I exposure. Exposure‐response modeling was conducted to describe the relationship between apoA‐I exposure and total or ATP binding cassette transporter A1‐(ABCA1)‐dependent CEC and to identify clinical predictors of CEC.ResultsA two‐compartment model described apoA‐I PK. ApoA‐I clearance was slightly lower in subjects with AMI, whereas baseline apoA‐I was marginally higher in female and Japanese subjects. Covariate effects on apoA‐I exposure were in the order of 10% and thus not clinically relevant. The relationships between apoA‐I exposure and CECs were described by nonlinear models. Simulations showed CEC elevation resulting from apoA‐I exposure increment was comparable in AMI and non‐AMI subjects; no covariate had clinically meaningful effects on CEC. Simulations also demonstrated that CEC in patients with AMI post 6 g CSL112 dosing was substantially elevated compared to placebo and lower dose levels.ConclusionsThe model‐based exposure‐response analysis demonstrated, irrespective of body weight, sex and race, that fixed 6 g CSL112 dosing causes a desired CEC elevation, which may benefit AMI patients by potentially reducing early recurrent cardiovascular event risk.