bluuebunny/crossref_metadata_2025_split huggingface dataset:
A convenient clinical nomogram for predicting the cancer-specific survival of individual patients with small-intestine adenocarcinoma
Authors: Wang Na , Yang Jin , Lyu Jun , Liu Qingqing , He Hairong , Liu Jie , Li Li , Ren Xuequn , li zhendong 
Published: January 2020

Abstract
Background: The objective of this study was to develop a practical nomogram for predicting the cancer-specific survival (CSS) of patients with small-intestine adenocarcinoma. Methods: Patients diagnosed with small-intestine adenocarcinoma. between 2010 and 2015 were selected for inclusion in this study from the Surveillance, Epidemiology, and End Results (SEER) database. The selected patients were randomly divided intothe training and validation cohorts at a ratio of 7:3.The predictors of CSS were identified by applying both forward and backward stepwise selection methods in a Cox regression model. The performance of the nomogram was measured by the concordance index (C-index), the area under receiver operating characteristic curve (AUC), calibration plots, the net reclassification improvement (NRI), the integrated discrimination improvement (IDI), and decision-curve analysis (DCA). Results: Multivariate Cox regression indicated that factors including age at diagnosis, sex, marital status, insurance status, histology grade, SEER stage, surgery status, T stage, and N stage were independent covariates associated with CSS. These factors were used to construct a predictive model, which was built and virtualized by a nomogram. The C-index of the constructed nomogram was 0.858. The AUC values indicated that the established nomogram displayed better discrimination performance than did the seventh edition of the American Joint Committee on Cancer TNM staging system in predicting CSS. The IDI and NRI also showed that the nomogram exhibited superior performance in both the training and validation cohorts. Furthermore, the calibrated nomogram predicted survival rates that closely corresponded to actual survival rates, while the DCA demonstrated the considerable clinical usefulness of the nomogram. Conclusion: We have constructed a nomogram for predicting the CSS of small-intestine adenocarcinoma patients. This prognostic model may improve the ability of clinicians to predict survival in individual patients and provide them with treatment recommendations.
Tranexamic Acid is Associated with Reduced Mortality, Hemorrhagic Expansion, and Vascular Occlusive Events in Traumatic Brain Injury – Meta-analysis of Randomized Controlled Trials
Authors: July Julius , Pranata Raymond 
Published: January 2020

Abstract
Introduction This systematic review and meta-analysis aimed to synthesize the latest evidence on the efficacy and safety of tranexamic acid (TXA) on traumatic brain injury (TBI). Methods We performed a systematic literature search on topics that compared intravenous TXA to placebo in patients with TBI up until January 2019 from several electronic databases. Results There were 30.522‬ patients from 7 studies. Meta-analysis showed that TXA was associated with reduced mortality (RR 0.92 [0.88, 0.97], p=0.002; I 2 : 0%) and hemorrhagic expansion (RR 0.79 [0.64, 0.97], p=0.03; I 2 : 0%). Both TXA and control group has a similar need for neurosurgical intervention (p=0.87) and unfavourable Glasgow Outcome Scale (GOS) (p=0.59). The rate for vascular occlusive events (p=0.09), and its deep vein thrombosis subgroup (p=0.23), pulmonary embolism subgroup (p=1), stroke subgroup (p=0.38), and myocardial infarction subgroup (p=0.15) were similar in both groups. Subgroup analysis on RCTs with low risk of bias showed that TXA was associated with reduced mortality and hemorrhagic expansion. TXA was associated with reduced vascular occlusive events (RR 0.85 [0.73, 0.99], p=0.04; I 2 : 4%). GRADE was performed for the RCT with low risk of bias subgroup, it showed a high certainty of evidence for lower mortality, less hemorrhage expansion, and similar need for neurosurgical intervention in TXA group compared to placebo group. Conclusion TXA was associated with reduced mortality and hemorrhagic expansion but similar need for neurosurgical intervention and unfavorable GOS. Vascular occlusive events were slightly lower in TXA group on subgroup analysis of RCTs with low risk of bias.
Development and Validation of Dust Exposure Prevention Questionnaire for Heart Patients Based on the Health Belief Model
Authors: Noroozi Farzaneh , Eisapareh Kumars , Bahadori Alireza , Bagherzadeh Razieh , Ghahremani Leila , mokarami hamidreza 
Published: January 2020

Abstract
Background: Many heart patients suffer from respiratory failures. It is necessary to prevent exposure to dust by taking educational steps to change the behaviors of heart patients.The present study aimed at developing and validating a dust prevention questionnaire based on the health belief model . Methods: A mixture of qualitative and quantitative methods was used to design and develop the desired tool in 2018. The qualitative section of the research was performed to identify the preventive behaviors needed by cardiovascular patients when exposed to dust using the expert panel’s opinions and literature review. The quantitative section of the research was performed to evaluate the psychometric properties of the research tool. The research population included 417 people with heart diseases referred to a heart hospital in Bushehr, Iran. Results: The designed questionnaire included a total of 27 items divided into six domains, namely perceived susceptibility, perceived barriers, perceived severity, perceived benefits, guidance of action, and self-efficacy. The means of Content Validity Ratio (CVR) and Content Validity Index (CVI) were 0.93 and 0.9, respectively. In addition, all designed items had good correlations with the total scores of their related domains. However, the model fit indices were not suitable. Hence, to fully fit the model to the data, it was tried to improve the model by releasing some parameters based on the modification indices suggested by AMOS software. The modified model had an acceptable fit . The results of Cronbach’s alpha coefficient also showed the appropriate reliability of all six domains. Conclusions: The designed questionnaire had desirable psychometric properties and appropriate validity to determine the factors involved in preventing dust complications in heart patients. Designing this questionnaire could also be considered as an effective step to evaluate the effective factors in preventing dust complications in patients with heart diseases .
Subclinical Cardiovascular Risk Signs in Adults with Juvenile Idiopathic Arthritis in Sustained Remission
Authors: Aranda-Valera Inmaculada Concepcion , Rosa Iván Arias de la , Roldan-Molina Rosa , Abalos-Aguilera Maria del Carmen , Torres-Granados Carmen , Patiño-Trives Alejandra , Luque-Tevar Maria , Ibañez-Costa Alejandro , Guzman-Ruiz Rocio , Malagón Maria del Mar , Escudero-Contreras Alejandro , Lopez-Pedrera Chary , Collantes-Estevez Eduardo , Barbarroja Nuria 
Published: January 2020

Abstract
Background:Juvenile Idiopathic Arthritis (JIA) is one of the most common chronic diseases of childhood that often persists into adulthood and can result in significant long-term morbidity. As a long lasting chronic inflammatory disease, concern has been raised regarding the risk of premature development of cardiovascular disease (CVD) in JIA. This study aims to determine whether adults with JIA in clinical remission and medium-long duration of the disease display subclinical signs of CVD risk. Methods: This is a cross-sectional study including 25 patients diagnosed with JIA according to the International League of Associations for Rheumatology criteria (ILAR 2001) and 25 age- and sex-matched controls. Remission was determined by JADAS10<1 and according to Wallace criteria. The presence of traditional CVD risk factors was analyzed. An extensive clinical analysis including body mass index (BMI), lipid profile, homeostatic model assessment – insulin resistance (HOMA-IR) and arterial blood pressure was performed. Intima media thickness of the common carotid artery (cIMT) was measured as a marker of subclinical atherosclerosis. Several proinflammatory cytokines, molecules involved in the endothelial dysfunction and adipokines were quantified on serum by ELISA. In vitro studies were carried out in healthy peripheral mononuclear cells (PBMCs), adipocytes and endothelial cells which were treated with serum from JIA patients under sustained remission. The expression of inflammatory molecules, oxidative stress and endothelial activation markers and adipokines was analyzed. Results : Mean duration of the disease was 13.47 ± 5.47 years. Mean age was 25.11 ± 7.21. Time in remission was 3.52 ± 3.33 years. CVD risk factors were similar in JIA patients and controls. However, cholesterol levels were significantly elevated in JIA patients. Serum levels of adipocytokines, oxidative stress and endothelial activation markers were elevated in serum and PBMCs from JIA patients. Serum of those JIA patients induced the activation of adipocytes, endothelial cells and healthy PBMCs. Conclusions: Long-term JIA adult patients in remission might have subclinical signs of inflammation and CVD risk, showed by an increase in the levels of inflammatory cytokines, endothelial activation and oxidative stress markers and adipokines, molecules closely involved in the alteration of the vascular system. Thus, CVD risk assessment might be considered as part of routine clinical care in those patients.
Quantitative ethnopharmacological documentation and molecular confirmation of medicinal plants used by the Manobo tribe of Agusan del Sur, Philippines
Authors: Dapar Mark Lloyd Granaderos , Alejandro Grecebio Jonathan Duran , Meve Ulrich , Liede-Schumann Sigrid 
Published: January 2020

Abstract
Background Philippines is renowned as one of the species-rich countries and culturally megadiverse in ethnicity worldwide. Ethnomedicinal knowledge of Indigenous Cultural Communities/Indigenous Peoples (ICCs/IPs) is vital for biodiversity conservation and healthcare improvement. This study aims to document the traditional practices, medicinal plant use, and knowledge; to determine the relative importance, consensus, and the extent of all medicinal plants used; and to integrate molecular confirmation to some medicinal plants used by the Agusan Manobo. Methods Quantitative ethnopharmacological data were obtained using semi-structured interviews, group discussions, field observations, and guided field walks with a total of 335 key informants comprising of tribal chieftains, traditional healers, community elders and residents of the community with their traditional medical knowledge. The use categories (UC), use report (UR), fidelity level (FL), and informant consensus factors (ICF) were quantified. The informants' medicinal plant use knowledge and practices were statistically analyzed using the descriptive and inferential statistics Mann-Whitney U and Kruskal-Wallis tests. Results A total of 122 medicinal plant species belonging to 108 genera and 51 families, used in 16 use categories, were collected and identified. Integrative molecular approach confirmed 24 species with uncertain identity using multiple universal markers. The highest ICF (0.96) was cited for the category of abnormal signs and symptoms (ASS). The maximum FL values of 100% were found for Carica papaya L., Premna odorata Blanco, Cinnamomum mercadoi S.Vidal, Tinospora crispa (L.) Hook.f. & Thomson, and Ficus concinna (Miq.) Miq. used for the treatment of dengue fever, cough with phlegm, stomach trouble, joint pain, and fracture and dislocation, respectively. The highest UR (1134) and UC (12) was reported for Anodendron borneense (King & Gamble) D.J.Middleton. Statistically, the medicinal plant knowledge among respondents was significantly different ( p <0.001) when grouped according to education, gender, position, occupation, civil status, and age but not significantly different ( p =0.379) when grouped according to location. Conclusion Documenting such traditional knowledge of medicinal plants and practices is highly important for future management and conservation strategies of these plant genetic resources. This quantitative ethnopharmacological study will serve as a future reference not only for more ethnopharmacological documentation but also for further pharmacological studies and public healthcare improvement.
Oncolytic Newcastle disease virus delivered by Mesenchymal stem cells-engineered system enhances the therapeutic effects altering tumor microenvironment in a murine papillomavirus tumor model
Authors: Keshavarz mohsen , Ebrahimzadeh Mir Saeed , Miri Seyed Mohammad , Dianat-Moghadam Hassan , Ghorbanhosseini Seyedeh Sara , Mohebbi Seyed Reza , Keyvani Hossein , Ghaemi Amir 
Published: January 2020

Abstract
Background: Cervical cancer is the most common human papillomavirus (HPV)-related cancer caused by persistent genital high-risk HPV infection. Cancer immunotherapy has represented great potential as a new promising cancer therapeutic approach. Here, we report Mesenchymal stem cells (MSCs) as a carrier for the delivery of oncolytic Newcastle disease virus (NDV) for the treatment of HPV-associated tumor.Methods: For this purpose, MSCs obtained from the bone marrow of C57BL mice, then cultured and characterized subsequently by the flow cytometry analysis for the presence of cell surface markers. In this study, we sought out to determine the impacts of MSCs loaded with oncolytic NDV on splenic T cell and cytokine immune responses, caspase-3 and -9 expression, and myeloid and myeloid-derived suppressor cells (MDSCs) by histological and immunohistochemical studies in the tumor microenvironment (TME).Results: our findings proved that MSCs possess both migratory capacity and tumor tropism toward transplanted tumor tissue after peritumoral administration. Tumor therapy experiments indicated that oncolytic NDV delivered by MSCs-engineered system significantly reduces tumor growth, which is associated with the enhancement of E7-specific lymphocyte proliferation, CD8+ T cell cytolysis responses, and splenic IFN-γ, IL-4 and IL-12 responses compared with control groups. Moreover, the treatment upregulated the concentration of apoptotic proteins (caspase 3 and 9) and increased infiltration of tumor microenvironment with CD11b+myeloid and Gr1+MDSCs cells.Conclusions: Our data suggest MSCs carrying oncolytic NDV as a potentially effective strategy for cancer immunotherapy through inducing splenic Th1 immune responses and MDSCs expansion in the tumor microenvironment.
Design, rationale, and analysis plan for the Stand Up for Health trial in contact centres: a stepped wedge feasibility study
Authors: Parker Richard A. , Manner Jillian , Sivaramakrishnan Divya , Baker Graham , Stoddart Andrew , Lloyd Scott , Jepson Ruth 
Published: January 2020

Abstract
Background: Contact centres are one of the most sedentary workplaces, with employees spending a very high proportion of their working day sitting down. About a quarter of contact centre staff regularly experience musculoskeletal health problems due to high levels of sedentary behaviour, including lower back pain. There have been no previous randomised studies specifically aiming to reduce sedentary behaviour in contact centre staff. To address this gap, the Stand Up for Health (SUH) study aims to test the feasibility and acceptability of a complex theory-based intervention to reduce sedentary behaviour in contact centres. Methods: The Stand Up for Health study has a stepped wedge cluster randomised trial design, which is a pragmatic design whereby clusters (contact centres) are randomised to time points at which they will begin to receive the intervention. All contact centre staff have the opportunity to experience the intervention. To minimise the resource burden in this feasibility study, data collection is not continuous, but undertaken on a selective number of occasions, so the stepped wedge design is “incomplete”. Eleven contact centres in England and Scotland have been recruited, and the sample size is approximately 27 per centre (270 in total. The statistical analysis will predominantly focus on assessing feasibility, including the calculation of recruitment rates and rates of attrition. Exploratory analysis will be performed to compare objectively measured sedentary time in the workplace (measured using an activPAL™ device) between intervention and control conditions using a linear mixed effects regression model. Discussion: This is the first stepped wedge feasibility study seeking to reduce sedentary behaviour in call centres. We employ an incomplete stepped wedge design to restrict data collection to certain time points to make data collection feasible. This trial will potentially inform the design of a future large multi-centre stepped wedge trial.
Improved survival rate and functional recovery of TKA in cementless fixation compared with cemented component: a systematic review and meta-analysis
Authors: Liu Yuan , Zeng Yi , Wu Yuangang , Li Mingyang , Xie Huiqi , Shen Bin 
Published: January 2020

Abstract
Background: Whether the cement could be given up in total knee arthroplasty (TKA) was still in controversy. We perform this meta-analysis to compare the rate of revision and functional recovery between two kinds of fixation in TKA. Methods: Randomized controlled trials (RCTs), prospective/retrospective observational studies from PubMed (on 2019 Sep), EMBASE (on 2019 Sep), and the Cochrane Central Register of Controlled Trials (CENTRAL) and Web of Science (on 2019 Sep) were searched. Continuous outcomes were presented as mean difference or standard mean difference with 95% CI and discontinuous outcomes were reported as relative risk (RR) with 95% CI. Random-effects or fixed-effects model was conducted to analyze the extracted data. The PRISMA guidelines and Cochrane Handbook were adopted to assess the quality of the results reported in included studies to ensure that the results of our meta-analysis were reliable and veritable. The continuous and dichotomous outcome were collected in a standard form, and the data were analysed by using Review Manager 5.3 software. Finally, the results were presented in the Forest plots. The rate of revision and reasons caused revision was the primary outcome of our study.Results: Twenty-six studies involving 2369 patients in cementless TKA and 2654 patients in cemented TKA were finally included in our meta-analysis. 26 studies were divided into three subgroups according to the length of follow-up. The studies in the first subgroup followed less than 5.5 years, the second followed less than 10.5 years, and the third followed more than 10.5 years. Cementless fixation significantly decreased the rate of aseptic loosing (p=0.0002) and revision (p=0.0002) in the first subgroup. Other reasons such as periprosthetic joint infection (PJI), instability and polyethylene wear were not significantly different between two groups. Significantly better functional recovery was got in cementless TKA in terms of Knee Society Score (p=0.004) and Oxford Knee Score (p=0.007). Significantly less patients in cementless group require manipulation under anesthesia (p=0.007). However, there was no significant difference regarding the rate of complication between two kinds of fixation in TKA.Conclusion: Not only the rate of aseptic loosing was decreased, rate of revision was also significantly decreased in cementless TKA within 5.5 years. In addition, the cementless TKA performed better in postoperative functional recovery according to Knee Society Function Score and Oxford Knee Score. However, the rate of complication was not significantly different in two kinds of fixation in TKA.
Circulating Neutrophil-to-Lymphocyte Ratio at Admission Predicts the 6-monthss Outcome in Acute Traumatic Cervical Spinal Cord Injury Patients: A Retrospective Study
Authors: Zhao Jian-Lan , Lai Song-Tao , Du Zhuo-Ying , Sun Yi-Rui , Yuan Qiang , Wu Xing , Li Zhi-Qi , Hu Jin , Xie Rong 
Published: January 2020

Abstract
Background: The prognostic value of Neutrophil-to-Lymphocyte Ratio (NLR) for the outcome of acute cervical traumatic spinal cord injury (tSCI) patients has rarely been studied by now throughout the world. Methods: We performed a single-center retrospective cohort study to evaluate the prognostic value of NLR from peripheral whole blood count in patients with acute cervical tSCI. Patients within 6 hours of acute cervical tSCI treated between Dec 2008 and May 2018 in Huashan Hospital of Fudan University were enrolled. Outcomes of patients with tSCI were assessed using American spinal injury association Impairment Scale (AIS). 6-month outcomes were dichotomized into poor outcome group (AIS A to C) and good outcome group (AIS D and E). Uni- and multivariate analyses were performed to assess the independent predictors of 6-month outcome. Two prediction models based on admission characteristics were built to evaluate the prognostic value of NLR. The discriminative ability of predictive models was evaluated using the area under the curve (AUC). Results: A total of 377 patients were identified from our single center in China PR. Multivariate analysis showed that age, AIS grade at admission, NLR (p<0.001) and coagulopathy (p = 0.003) were independent predictors of the 6-months outcome for acute cervical tSCI patients. The model combing NLR and standard variables (AUC=0.944; 95% CI, 0.923-0.964) showed a more favorable prognostic value than that without NLR (AUC=0.841; 95% CI, 0.798-0.885) in terms of 6-month outcome. Conclusions: NLR is firstly identified as an independent predictor of the 6-month outcome in acute cervical tSCI patients worldwide. The prognostic value of NLR is favorable, and a high NLR is associated with poor outcome in patients with acute cervical tSCI.
Detection of fractures of hand and forearm in whole-body CT for suspected polytrauma in intubated patients
Authors: Münn Friederike , Laun Reinhold A , Asmus Ariane , Bülow Robin , Bakir Sinan , Haralambiev Lyubomir , Eisenschenk Andreas , Kim Simon 
Published: January 2020

Abstract
Background: The aim of this study was to evaluate the potential of whole-body CT for diagnosis of hand and forearm fractures in intubated patients with suspected polytrauma. Methods: We performed a retrospective analysis on data collected from two trauma centres in Germany, including demographics, ISS, clinical symptoms, depiction in whole-body CT, and time to diagnosis. Results: Out of 426 patients included in the study, 66 (15.5%) suffered a hand or forearm fracture. The total number of fractures was 132. The WBCT report mentioned 98 (74.2 %). 16 (12,1 %) fractures of 12 patients were diagnosed later than 24 hrs after admission. Late diagnoses of fractures of the hand occurred more often if the hand was not fully included in the CT scan field. The sensitivity of WBCT for cases with fractures of hand and/or forearm with full inclusion of the corresponding area in the scan field was 80.2 %. Conclusions: This study shows that WBCT is a valuable diagnostic tool for hand fractures in polytrauma patients. Hands should be evaluated regardless of clinical presentation in intubated patients after suspected polytrauma if they are included in the whole-body CT.