bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymorphisms of CYP1A1, CYP1A2, CYP19, and SULT1A1 genes in women with early miscarriage
Authors: Noskova I. N. , Artymuk N. V. , Gulyaeva L. F. 
Published: December 2019

Aim. To determine the frequency of the polymorphisms within the genes encoding estrogen metabolism enzymes: CYP1A1 (rs4646903), CYP1A2 (rs762551), CYP19 (rs700519) and SULT1A1 (rs9282861) in women with early miscarriage.Materials and Methods. We recruited 103 consecutive women who experienced early miscarriage (< 12 weeks of pregnancy, n = 103) and 257 women without past medical history of adverse pregnancy outcomes. Following DNA extraction, we genotyped all samples by means of restriction fragment length polymorphism analysis. We analyzed the polymorphisms within the CYP1A1 gene (T264 → C, rs4646903), CYP1A2 gene (C734 → A, rs762551), CYP19 gene (C → T, rs700519), and SULT1A1 gene (G638 → A, rs9282861).Results. We found a significantly increased prevalence of the mutant allele C as well as T/C and C/C genotypes of the rs4646903 polymorphism within the CYP1A1 gene and mutant T allele along with the T/C genotype of the rs700519 polymorphism within the CYP19 gene in women with early miscarriage as compared with those having a normal pregnancy course. Concurrently, we detected a reduced frequency of the C/A genotype of the rs762551 polymorphism within the CYP1A2 gene in patients who suffered from early miscarriage. The risk of miscarriage was significantly increased in carriers of CYP1A2 (rs762551 C/C) + CYP1A1 (rs4646903 T/C + C/C) + CYP19 (rs700519 C/T), CYP1A2 (rs762551 C/C) + CYP1A1 (rs4646903 T/C + C/C) + SULT1A1 (rs9282861 G/G) + CYP19 (rs700519 C/T), CYP19 (rs700519 C/T) + SULT1A1 (rs9282861 G/G), (CYP1A2 (rs762551 C/C) + CYP1A1 (rs4646903 T/C + C/C); CYP1A2 (rs762551 C/C) + CYP19 (rs700519 C/T), CYP19 (rs700519 C/T) + CYP1A1 (rs4646903 T/C + C/C), and SULT1A1 (rs9282861 G/G) + CYP1A1 (rs4646903 T/C + C/C) haplotypes. Investigation of the possible gene-environment interactions found a considerable increase in CYP1A1 (rs4646903 T/C) + CYP1A2 (rs762551 A/A) and CYP1A1 (rs4646903 T/C) + SULT1A1 (rs9282861 A/A) haplotypes in conjunction with a CYP1A2 (rs762551 A/A) + SULT1A1 (rs9282861 G/A) haplotype.Conclusion. Patients with early miscarriage more frequently have the mutant allele C as well as C/T or C/C genotypes of the rs4646903 polymorphism within the CYP1A1 gene and mutant allele T (in particular within the C/T genotype) of the rs700519 polymorphism within the CYP19 gene; in contrast, C/A genotype of the rs762551 polymorphism within the CYP1A2 gene was less common in these patients. Specific risk haplotypes revealed in our study may indicate a combination of estrogen-dependent and chemically induced process caused by the bioactivation of exogenous xenobiotics in patients with early miscarriage.
ENGLISH PROFICIENCY OF HOTEL FRONT-LINERS: WHAT AND WHY?
Authors: Datu Yerly A. 
Published: December 2019

English proficiency for hotel front-liners is paramount in giving excellent service for the guests. 60 seconds in the beginning of interaction leave the first impression for them. Therefore, oral communication skills play a significant role as a part of a must have competence for front-liners. This study was triggered by initial findings at some hotels in Surabaya where there was a discrepancy between hotel leaders’ perception and real English proficiency of their front-liners. The hotel leaders perceived lower than the passing grade of the hotel and urgency of upgrading their competence emerged. Two research questions should be answered: (1) WHAT level of the front liners’ English proficiency was, and (2) WHY they experienced difficulty when facing foreign guests. To answer the questions, a descriptive qualitative research employing a case study approach was conducted. The 3-star hotel consisting 20 participants was involved. Test of Business English Communication Competence Version 2.0 (TBECCv.2.0) was given to participants. TBECCv.20 was an ESP test created and developed for front-liners. After running the test, an online questionnaire was disseminated and interviews were also conducted for triangulation. Results revealed that the score range of 50-59 received the highest percentage; 40% which showed their English proficiency needed to be upgraded. Reasons of difficulty handling the foreign guests were due to (1) L1 interference, (2) educational background, (3) less English exposure, (4) the absence of ESP test at recruitment process. The study recommended further study for other categories of hotel and the staff professional development was recommended as well.
ANALISIS DAMPAK PEMBANGUNAN JALAN TOL MEDAN TEBING TINGGI TERHADAP KEGIATAN JAJANAN USAHA MIKRO KECIL DAN MENENGAH DI PASAR BENGKEL
Authors: Manullang Januardin , Samosir Hottua 
Published: December 2019

The workshop market has a pretty good potential for “dodol” business. Dodol has become a characteristic of this region so that the demand will remain stable. Sales of dodol, which increases every year, makes this food have a bright prospect to develop because the raw materials for its manufacture are available locally. The purpose of this research is to provide analysis and the impact of existing problems, from a phenomenon due to the opening of a high-cliff-field toll road to economic life and the selling power of snacks and food in small and medium-sized enterprises.There fore, it is not out of business due to development impacts of high-cliff-field toll road. The importance of carrying out this research was to give a solution and input from the district government as well as the North Sumatra provincial government in the management of small and medium-sized micro enterprises in the workshop market. Type of Research was Case Research (Case Study). The impact of the construction of the Medan-Tebing Tinggi toll road is very important for the MSME community around the workshop market. The impact was not only on the community but also on the regional government.Per capita income from the MSME market workshop decreased dramatically to 50% of income per month. In addition, fewer workers were employed by MSMEs, where previously they could employ 2 to 5 people per store. Now they can only employ 1 to 2 people. Regional Original Income derived from restitution has significantly dropped since the construction of the toll road. On the other hand, the positive impact felt by the market community is that there was no congestion and the air pollution decreased.
SOSIALISASI CITRA BARU PENCAK SILAT SEBAGAI SOFT POWER INDONESIA KEPADA SISWA SMP NEGERI 2 KOTA BANDUNG
Authors: Narulita Assyfa , Fajar Candra Muhammad , Nova Riesma Reannissa Sabrina , Rahman Junita Budi , Aditiany Savitri , Dipura Dadan Surya 
Published: December 2019

Citra Pencak Silat di kalangan anak muda masih terbatas hanya sebagai warisan seni-budaya kuno, statis dan tidak menarik. Padahal Pencak Silat semakin dikenal di dunia, dan diperlukan oleh Indonesia sebagai sumber soft power di era globalisasi masa kini. Oleh karena itu artikel ini bertujuan untuk mendeskripsikan kegiatan sosialisasi mengenai citra baru Pencak Silat sebagai soft power Indonesia kepada murid SMP 2 di kota Bandung oleh tim mahasiswa dan Dosen Universitas Padjadjaran dalam kegiatan PKM. Tujuannya adalah untuk menanamkan kesadaran kolektif pelajar SMP sejak usia dini mengenai Pencak Silat sebagai soft power Indonesia yang perlu dilestarikan dan diamalkan. Sosialisasi dilaksanakan dengan menggunakan strategi komunikasi yang berpedoman pada siapa, apa dan bagaimana materi substansi disampaikan. Melalui metoda ini sosilisasi terlaksana sesuai dengan bidang kompetensi pihak pemberi sosialisasi sehingga materi substansi bersifat komprehensif dan saling melengkapi dalam memberi pengetahuan dan kesadaran kepada para siswa SMP. Dengan media penyampaian yang menarik bagi sasaran berusia anak muda, telah membuat mereka tampak tertarik dan bersemangat dalam mengikuti proses sosialisasi sebagai langkah awal untuk meminati Pencak Silat. The image of Pencak Silat among young people is still limited only as an ancient, static and unattractive heritage of ancient arts and cultures. Even though Pencak Silat is increasingly known in the world, and is needed by the Indonesia as a source of soft power in the current era of globalization. Therefore this article aims to describe the socialization activities regarding the new image of Pencak Silat as Indonesian soft power to SMP 2 students in Bandung by the student team and Padjadjaran University Lecturers in PKM activities. The aim is to instill a collective awareness of junior high school students from an early age about Pencak Silat as Indonesia's soft power that needs to be preserved and practiced. The socialization was carried out by using a communication strategy based on who, what and how the material was delivered. Through this method socialization is carried out in accordance with the field of competence of the providers of the socialization so that the substance of the material is comprehensive and complementary in providing knowledge and awareness to junior high school students. With a delivery media that appeals to young people, it has made them look interested and enthusiastic in following the socialization process as a first step to attract Pencak Silat
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in children
Authors: Akhaladze D. G. , Rabaev G. S. , Grachev N. S. 
Published: December 2019

Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) is treatment of choice for determined group of adult patients. Cytoreduction and HIPEC is usually used in patients with ovarian, gastric and colorectal cancer, appednix cancer, peritoneal mesothelioma and in some tumors of another localization. The experience of cytoreductive surgery and HIPEC in childhood is limited due to the lower frequency of peritoneal carcinomatosis in pediatric population. However, about 30% of malignant tumors in children develop in peritoneal cavity and pelvis. High recurrence rate are typical for these tumors, particularly due to tumor rupture. Taking into consideration low frequency of epithelioid tumors in children HIPEC is used for patients with other tumor types such as desmoplastic small round cell tumor (DSRCT), germ cell tumors, rhabdomyosarcoma and others. The aim o this paper is the review of the literature and present experience analysis of cytoreductive surgery and HIPEC in children.
Herramientas tecnológicas para el estudio e intervención de la biomecanica en el deporte de alto rendimiento: una mirada desde fisioterapia
Authors: Alfonso Mantilla José Iván 
Published: December 2019

La biomecánica es el área de estudio de componentes cinéticos y cinemáticos implicados en el movimiento corporal humano profundizando en elementos tales como fuerza muscular, rangos de movimiento, aceleración, velocidad y desplazamiento. En el deporte de alto rendimiento, el estudio de las variables biomecánicas que inciden en el gesto motor es de vital importancia para entender los mecanismos de control y adaptación del movimiento a actividades especificas, con el fin de desarrollar programas para mejorar la ejecución del movimiento en determinadas fases del gesto deportivo y prevenir lesiones a partir del estudio del gesto motor. Por tal motivo el objetivo de este artículo es realizar una revisión sistemática de la literatura sobre el uso de la tecnología para la evaluación e intervención de la biomecánica en el deporte de alto rendimiento
Study of soft tissue microcirculation in surgical intervention zone before and after single-stage correction of feet multicomponent deformities in patients with cerebral palsy
Authors: Shchurova E. N. , Leonchuk S. S. , Popkov D. A. 
Published: December 2019

Introduction.Simultaneous correction of severe deformities of the feet may be accompanied by a negative effect on the trophism of the adjacent soft tissues. However, the literature does not pay enough attention to the analysis of the blood supply to soft-tissue structures in the field of surgical intervention in the correction of complex deformities of the feet. The aim of the study is to investigate condition of soft tissues blood supply in the area of surgery before and after simultaneous correction of severe feet deformities by triple arthrodesis in patients with cerebral palsy.Material and methods.The article is based on the results of study of 21 cerebral palsy patients with multicomponent feet deformities. All patients underwent simultaneous correction of foot deformities with usage of internal fixation. Patients were examined for the soft tissues blood supply (skin, subcutaneous fat, muscles) in the area of surgery using laser and high-frequency Doppler flowmetry before and after performing all phases of foot surgery.Results.Capillary skin blood flow after performing all stages of operation, removing tourniquet and suturing tended to increase in all areas of measurement, but significantly increased on the dorsum of the foot, at points 1 (by 53.3 %, p <0.05), 4 (by 69.0 %, p<0.05), and at point 6 (53.9 %, p <0.05). Indicators of blood flow of subcutaneous fat and muscle tissue after performing all stages of operation and removal of tourniquet did not significantly differ from the preoperative level. In the long-term follow-up period, all examined patients showed good clinical results in 81 % of cases, satisfactory – in 19 % of patients who noted periodic moderate pain in the feet after a long walk. There were nounsatisfactory results.Conclusion.After simultaneous intraoperative correction of severe feet deformities by triple arthrodesis in the area of operative wound in patients with cerebral palsy, there is no decrease in the microcirculatory blood flow in soft tissuesin the surgical intervention area. There is either stabilization or an increase in the perfusion of these structures.
Effect of Ischemic Postconditioining on Change of Immunoreactivity Level to PECAM-1/CD31 in Rat Neocortex Structures after Global Brain Ischemia
Authors: Shcherbak N. S. , Gurbo A. G. , Yukina G. Yu. , Thomson V. V. , Shlyakhto E. V. 
Published: December 2019

Introduction. Ischemic postconditioning (IPostC) of the brain can be considered as a promising approach to limit reperfusion injury in the ischemic area of the brain. Objective – to study the effect of IPostC after global cerebral ischemia on the level of immunoreactivity to PECAM-1/CD31 in the structures of layers II, III and V of the neocortex of rats at different periods of the reperfusion period.Material and methods. In male Wistar rats, a 10-minute global cerebral ischemia was modeled followed by IPostC in the form of reperfusion-ischemia at 15sec/15sec. In the early (2 days) and late (7 days) reperfusion periods after damaging ischemia, the number of morphologically unchanged neurons and the level of immunoreactivity to PECAM-1/CD31 in the structures of layers II, III and V of the neocortex were estimated.Results. It is shown that the use of IPostC by 2 days of reperfusion contributed to the increase in the number of unchanged neurons in layers II and III of 25.8 and 28.2 % (P<0.05), which was not accompanied by changes in the level of immunoreactivity to PECAM-1/CD31, to 7 days of reperfusion there was an increase in the number of unchanged neurons in layers II, III and V of 19.2, 22,1, 21,4 % (P<0.05) was observed a decrease in the level of immunoreactivity to PECAM-1/CD31 in the structures of these layers of 27.4, 39.4, and 16.7 % (P<0.05), respectively, when compared with similar indicators in groups without the use of IPostC.Conlusions. In the mechanisms of physiological reaction formed in the application of ischemic postconditioning after cerebral ischemia and leading to the preservation of the number of unchanged neurons in the late reperfusion period involved PECAM-1/CD31, which suggests that the protective potential of the phenomenon is realized by possible inhibiting the migration of neutrophils, monocytes and lymphocytes and extravasation of leukocytes from the systemic blood flow into the damaged area of the brain, i.e. through suppression of inflammatory response.
Neuroprotective efficiency of creatine-aminoacid complex compound in the model of ischemic stroke in rats
Authors: Mourovets V. O. , Lentsman M. V. 
Published: December 2019

Introduction.According to WHO data, stroke and its consequences rank second in mortality after coronary heart disease. Hundreds of clinical trials have yielded only one tool that can be used – intravenous administration of recombinant plasminogen activator, i.e. recanalization agent. The means for effective neuroprotection, despite the huge number of studies, remain not found.The aimof the work was in vivo study of neuroprotective effect of creatine amide (AC-PfA) on neurological and cognitive impairment in a model of ischemic stroke in rats.Material and methods.The model of stroke (FCI) was reproduced by occlusion of middle cerebral artery proximal segment. Neurological deficits were assessed by the latency of movement initiation (LMI), cognitive impairments – by a spatial version of Morris water maze. Four groups of animals were used: (1) negative control (FCI with administration of saline), (2) positive control (FCI with controlled hypothermia), (3) test substance (FCI with administration of AC-PfA) and (4) sham-operated animals.Results.Compared with negative control group, animals восtreated with AC-PfA showed lower latency of movement initiation a day after FCI, what indicates a better functional state of the basal ganglia and associative areas of the cortex. Hypothermia during FCI completely eliminated the effect of increasing LMI. In Morris water maze, animals treated with AC-PfA, in contrast to the negative control group, showed a decrease in platform search time during training, and in a probe trial differed statistically significantly in peripheral searching time and the number of crossings of the platform localization site. Hypothermia was not so effective, although not statistically significantly differs from the group with AC-PfA.Conclusions.A new derivative of creatine has a pronounced therapeutic efficacy in relation to cognitive impairment, and improves the functional state of the systems, controlling the motor activity of animals. At the same time, it exceeds or approaches the effects of hypothermia, known as an effective neuroprotective technique.
Bezdirinin Ruh Sağlığına Etkisi
Authors: AKBAŞ Ayla 
Published: December 2019

Amaç : Günümüzde
bezdiri (mobbing) sendromu her geçen gün çalışma hayatında yaygınlaşmaktadır.
Çalışmada, insan ilişkilerinde gözlemlenen bezdiri davranışının çalışanların
ruh sağlığı üzerindeki olumsuz etkilerinin kuramsal olarak önemini
vurgulamaktır.Tasarım/Yöntem: Literatüre dayanarak psikolojik, duygusal, sosyal
ve mesleki boyuttaki ‘bezdiri davranış modelleri’ sınıflandırılarak bezdiri ile
başa çıkmada psikolojik danışmadan yararlanılmasının ve bazı becerilerin
kazanılmasının ruh sağlığını korumada olası yararları irdelenmiştir.Sonuçlar: Bu çalışmada, bezdiri olgusunun tanımlanmasında literatürde karşılaşılan
kavram karmaşası ve anlamdaşlarıyla ilişkisi
ele alınarak bir kavram olarak irdelenmiş ve yönetim stratejisinde neden-sonuç
ilişkileri ile değerlendirilerek bezdiri ile mücadele stratejileri ve öneriler
sunulmuştur.Özgün Değer:Kuramsal boyutta çalışmalar
incelenmiş, bezdiren ve bezdiriye yönelik önermelerin gelecek
çalışmalara katkı sağlayabileceği değerlendirilerek rapor edilmiştir.
Comparative effect of three polishing systems on porcelain surface roughness after orthodontic bracket debonding and composite resin removal: An atomic force microscopy
Authors: Qabel Faeze , Talaei Riehane , Saeedi Saeedeh , Ghorbani Raheb , Ameli Nazila 
Published: December 2019

Purpose:
Porcelain polishing after orthodontic bracket debonding and resin removal is imperative to eliminate surface roughness and minimize the risk of plaque accumulation, periodontal disease, and porcelain discoloration. This study aimed to assess the effect of three polishing systems on porcelain surface roughness after orthodontic bracket debonding.

Materials and Methods:
Thirty porcelain blocks were divided into three groups. Surface roughness of the samples was first measured using atomic force microscopy (AFM) and recorded as baseline. Orthodontic brackets were bonded to blocks by composite resin. After bracket debonding, resin remnants were removed by tungsten carbide bur. The blocks were then polished with Sof-Lex discs, Meisinger, and Jota porcelain polishing kit. Surface roughness was measured again using AFM. The Shapiro–Wilk test, one-way ANOVA, and Tukey’s post hoc test were used for data analysis through SPSS version 18.0. Level of significance was set at 5%.

Results:
The mean change in surface roughness after polishing with Jota kit (56.6 nm) was significantly greater than that compared to Sof-Lex discs (10.7 nm) (P = 0.003) and Meisinger kit (26.6 nm) (P = 0.024). The mean change in surface roughness was not significantly different between Sof-Lex and Meisinger groups. Surface roughness significantly increased in all three groups (P < 0.05).

Conclusion:
Meisinger polishing kit and Sof-Lex discs were not significantly different in terms of the resultant surface roughness. Thus, the conventional use of Sof-Lex discs seems to be more cost-effective due to their lower cost.
Association between the Critical Shoulder Angle and Non-traumatic Rotator Cuff Tears
Authors: Jadhav Aniket , Desai Sanjay , Reddy Vikas , Kuruvilla Robin , Mahadeokar Pranav 
Published: December 2019

Background:
Moor et al. developed a critical shoulder angle (CSA) as a radiological parameter for the development of rotator cuff injury and degenerative changes of the glenohumeral joint. The objective of this study is to evaluate the association between CSA and the development of non-traumatic rotator cuff tears (RCTs) to further validate this study.

Materials and Methods:
The study was performed as an observational study dividing subjects into control and study groups, differing in the presence of non-traumatic RCT. The study group comprised 50 subjects with 40 subjects in the control group. All acceptable radiographs were evaluated, to measure the CSA in accordance with Moor et al.

Results:
The mean CSA of control subjects was 31.79° (± 1.89°), while that of study subjects were 37.85° (± 2.25°). The relative variability in the control group was about 6% and that in the study group was also 6%, indicating internal homogeneity of the study groups. Chi-square test applied to the distribution gave a P = 0.00001, representing an excellent association between the study groups and the CSA.

Conclusion:
There is a significant association between larger CSA and RCTs (P = 0.00001). Individual (quantitative) anatomical parameters may imply altered biomechanics, which are likely to induce RCTs, independent of trauma and degenerative glenohumeral joint disease.