bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: Response to Intra-arterial Cisplatin and Concurrent Radiotherapy Followed by Salvage Surgery in a Patient With Advanced Primary Sinonasal Low-Grade Non-intestinal Adenocarcinoma
Authors: Tachino Hirohiko , Takakura Hiromasa , Shojaku Hideo , Fujisaka Michiro , Akaogi Katsuichi , Kawabe Hideto , Naruto Norihito , Shojaku Hiroko , Noguchi Kyo , Miwa Shigeharu , Imura Johji , Maeda Yoshinobu 
Published: December 2020

Background: The clinical usefulness of concurrent chemoradiotherapy before surgery in the treatment of primary, locally advanced sinonasal low-grade, non-intestinal type adenocarcinoma (LG non-ITAC) is unclear.Methods: We present the first case report of the efficacy of super-selective intra-arterial cisplatin (CDDP) infusion concurrent with conventional fractionated radiotherapy (RT) for LG non-ITAC in a Japanese patient.Results: A white, rugged-marginal mass that was histopathologically diagnosed as LG non-ITAC occupied the right nasal cavity. Based on the imaging findings, including computed tomography, magnetic resonance imaging, and positron emission tomography, the tumor was diagnosed as T4aN0M0, stage IVa. After treatment, the nasal tumor disappeared leaving only a small bulge in the medial wall of the middle turbinate. The patient also underwent right transnasal ethmoidectomy performed as salvage surgery. A histopathological examination revealed that the lesion was replaced by granulation tissue with lymphocytic infiltration and hemosiderin-laden macrophages, and no viable tumor cells remained. In the seven years after treatment, the patient has not experienced any local recurrence or regional or distant metastasis.Conclusions: Super-selective intra-arterial CDDP infusion concurrent with conventional fractionated RT followed by salvage surgery might be useful for the management of sinonasal LG non-ITAC.
Effect of the OPTIMAL programme on self-management of multimorbidity in primary care: a randomised controlled trial
Authors: O’Toole Lynn , Connolly Deidre , Boland Fiona , Smith Susan M 
Published: December 2020

BackgroundEffective primary care interventions for multimorbidity are needed.AimTo evaluate the effectiveness of a group-based, 6-week, occupational therapy-led self-management support programme (OPTIMAL) for patients with multimorbidity.Design and settingA pragmatic parallel randomised controlled trial across eight primary care teams in Eastern Ireland with 149 patients with multimorbidity, from November 2015 to December 2018. Intervention was OPTIMAL with a usual care comparison.MethodPrimary outcomes were health-related quality of life (EQ-5D-3L) and frequency of activity participation (Frenchay Activities Index [FAI]). Secondary outcomes included independence in activities of daily living, occupational performance and satisfaction, anxiety and depression, self-efficacy, and healthcare utilisation. Complete case linear regression analyses were conducted. Age (<65/≥65 years) and the number of chronic conditions (<4/≥4) were explored further.ResultsA total of 124 (83.2%) and 121 (81.2%) participants had complete data at immediate and 6-month post-intervention follow-up, respectively. Intervention participants had significant improvement in EQ-VAS (visual analogue scale) at immediate follow-up (adjusted mean difference [aMD] = 7.86; 95% confidence interval [CI] = 0.92 to 14.80) but no difference in index score (aMD = 0.04; 95% CI = −0.06 to 0.13) or FAI (aMD = 1.22; 95% CI = −0.84 to 3.29). At 6-month follow-up there were no differences in primary outcomes and mixed results for secondary outcomes. Pre-planned subgroup analyses suggested participants aged <65 years were more likely to benefit.ConclusionOPTIMAL was found to be ineffective in improving health-related quality of life or activity participation at 6-month follow-up. Existing multimorbidity interventions tend to focus on older adults; preplanned subgroup analyses results in the present study suggest that future research should target younger adults (<65 years) with multimorbidity.
Lucas Sayılarının Max Matrislerde Bir Uygulaması
Authors: AKYÜZ Bahar , BAHŞİ Mustafa 
Published: December 2020

Bu çalışmada, L_n; n. Lucas sayısını göstermek üzere C=[L_(k+max⁡(i,j)-1) ]_(i,j=1)^n şeklinde bir Max matrisi tanımladık ve bu matrisin determinant, ters ve norm gibi bazı özelliklerini inceledik. İlk olarak, genel Max matrisi için bilinen sonuçları kullanarak C matrisinin determinantını ve tersini verdik. Daha sonra, C matrisinin Öklid normu için bir eşitlik ve spektral normu için bir üst sınır oluşturduk. Son olarak, C matrisinin Hadamard tersinin determinantını ve tersini hesapladık.
Kualitas Pelayanan Kesehatan di Puskesmas Padongko
Authors: M A Pananrangi , Nippi Andi Tenri , Panyyiwi Rahmat , Suprapto Suprapto 
Published: December 2020

Abstrak. Latar belakang; semakin meningkatnya kesadaran masyarakat akan haknya dalam memeperoleh pelayanan termasuk pelayanan kesehatan merupakan salah satu indikator positif meningkatnya kesadaran akan pentingnya kesehatan. Penelitian ini bertujuan untuk mengetahui kualitas pelayanan kesehatan di Puskesmas Padongko Kecamatan Barru Kabupaten Barru. Metode: penelitian ini tipe penelitian yang digunakan adalah dekriftif kualitatif. Data yang digunakan adalah data primer dan data sekunder. Untuk data primer sebagai informan adalah: pegawai Puskesmas Padongko, pasien dan tokoh masyarakat. Sementara data skunder dilakukan melalui penelusuran kepustakaan, jurnal dan karya ilmiah lainnya. Teknik pengumpulan data adalah: wawancara, observasi dan dokumentasi. Kemudian teknik analisis data yaitu; reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa meskipun masih kekurangan sarna dan prasarana, namun secara umum dapat disimpulkan bahwa Puskesmas Padongko sudah menunjukkan kualitas pelayanan kesehatan yang cukup baik. Kesimpulan: meskipun masih kekurangan sarana dan prasarana, namun secara umum dapat disimpulkan bahwa Puskesmas Padongko sudah menunjukkan kualitas pelayanan kesehatan yang cukup baik
Analisis Angka Kejadian Penyakit Infeksi Menular Seksual
Authors: Betan Abubakar , Pannyiwi Rahmat 
Published: December 2020

Latar Belakang; Penyakit menular seksual merupakan penyakit yang menular paling umum dan masalah kesehatan yang saat ini banyak menyita perhatian karena angka kejadian PMS cenderung terus meningkat.
Metode; Penelitian kuantitatif menggunakan metode deskriptif analitik dengan rancangan cross sectional studi. Analisis data dengan menggunakan analisis univariat dan bivariate dengan menggunakan uji statistic chi-square.
Hasil: uji statistik pengetahuan (p = 0,009), perilaku (p = 0,009), dan social ekonomi (p = 0,169) dengan kejadian infeksi menular seksual.
Kesimpulan; terdapat hubungan pengetahuan dan perilaku dan tidak terdapat hubungan social ekonomi dengan kejadian penyakit menular seksual
Aspirin Dosis Rendah untuk Mencegah Preeklamsia pada Kehamilan
Authors: Berliana Aulia 
Published: December 2020

Latar belakang. Hingga saat ini, algoritma skrining yang efektif untuk identifikasi wanita yang berisiko mengalami preeklamsia masih belum ada, sehingga pencegahan preeklamsia merupakan komponen penting dari perawatan prenatal. Sementara itu, pemberian aspirin dosis rendah pada ibu hamil diduga dapat mencegah preeklamsia pada kehamilan Sehingga tujuan dari literature review ini adalah untuk mengetahui efek terapi aspirin untuk mencegah preeklamsia pada kehamilan. Metode. Studi ini merupakan literature review, dengan sumber pustaka yang digunakan melibatkan sebanyak 21 pustaka Hasil. Beberapa penelitian menunjukkan efek terapi aspirin dosis rendah dapat menurunkan perkembangan preeklamsia, mengurangi kejadian kelahiran prematur dan kelahiran bayi kecil untuk usia kehamilan (small for gestational age) secara signifikan. Kesimpulan. Pengobatan dengan aspirin dosis rendah pada wanita dengan risiko tinggi untuk preeklamsia menghasilkan insiden yang lebih rendah dibandingkan dengan plasebo.
Radiative Supernova Remnants and Supernova Feedback
Authors: Koo Bon-Chul , Kim Chang-Goo , Park Sangwook , Ostriker Eve C. 
Published: December 2020

Abstract
Supernova (SN) explosions are a major feedback mechanism, regulating star formation in galaxies through their momentum input. We review the observations of SNRs in radiative stages in the Milky Way, to validate theoretical results regarding the momentum/energy injection from a single SN explosion. For seven supernova remnants (SNRs) where we can observe fast-expanding, atomic radiative shells, we show that the shell momentum inferred from H i 21 cm line observations is in the range of (0.5–4.5) × 105
M
⊙ km s−1. In two SNRs (W44 and IC 443), shocked molecular gas with momentum comparable to that of the atomic SNR shells has also been observed. We compare the momentum and kinetic/thermal energy of these seven SNRs with the results from 1D and 3D numerical simulations. The observation-based momentum and kinetic energy agree well with the expected momentum/energy input from an SN explosion of ∼1051 erg. It is much more difficult to use data/model comparisons of thermal energy to constrain the initial explosion energy, however, due to rapid cooling and complex physics at the hot/cool interface in radiative SNRs. We discuss the observational and theoretical uncertainties of these global parameters and explosion energy estimates for SNRs in complex environments.
AREPO-MCRT: Monte Carlo Radiation Hydrodynamics on a Moving Mesh
Authors: Smith Aaron , Kannan Rahul , Tsang Benny T.-H. , Vogelsberger Mark , Pakmor Rüdiger 
Published: December 2020

Abstract
We present arepo-mcrt, a novel Monte Carlo radiative transfer radiation-hydrodynamics (RHD) solver for the unstructured moving-mesh code arepo. Our method is designed for general multiple scattering problems in both optically thin and thick conditions. We incorporate numerous efficiency improvements and noise reduction schemes to help overcome efficiency barriers that typically inhibit convergence. These include continuous absorption and energy deposition, photon weighting and luminosity boosting, local packet merging and splitting, path-based statistical estimators, conservative (face-centered) momentum coupling, adaptive convergence between time steps, implicit Monte Carlo algorithms for thermal emission, and discrete-diffusion Monte Carlo techniques for unresolved scattering, including a novel advection scheme. We primarily focus on the unique aspects of our implementation and discussions of the advantages and drawbacks of our methods in various astrophysical contexts. Finally, we consider several test applications including the levitation of an optically thick layer of gas by trapped infrared radiation. We find that the initial acceleration phase and revitalized second wind are connected via self-regulation of the RHD coupling, such that the RHD method accuracy and simulation resolution each leave important imprints on the long-term behavior of the gas.
EFFECT OF STYRENE-BUTADIENE COPOLYMER (SBR) LATEX ON MECHANICAL AND TRANSPORT PROPERTIES OF PORTLAND CEMENT MORTAR
Authors: Hatungimana Daniel , Yazici Şemsi , Orhan Şevket , Mardani-Aghabaglou Ali 
Published: December 2020

ABSTRACT
Portland cement is extensively used as a binder in concrete production. However, with Portland cement production, 5% of the natural resources used in this production are consumed, constituting 5–7% of the total CO2 emission. In order to mitigate the environmental problems associated with cement production, styrene-butadiene rubber latex was used as cement replacement up to 20%. In this study, compressive strength, flexural strength, unit weight, water absorption, open porosity, water sorptivity and the chloride ion permeability of Portland cement mortar mixtures modified by styrene-butadiene rubber (SBR) polymeric latex were investigated. For this purpose, the sand/cement ratio and the water/cement ratio were kept constant as 3/1 and 0.5, respectively. In addition to the control mixture containing no polymer, 1, 2, 3, 5, 10 and 20 wt.% of cement was replaced with SBR. In this way, seven mortar mixtures were prepared. Mixed curing (wet cure and dry cure) method was applied to the mortar specimens. Results showed that up to a 5% replacement level, it is possible to improve the mechanical properties of cement mortars with SBR latex addition. However, at a 10% and 20% replacement level, SBR had a significant detrimental effect on the mechanical properties of polymer modified mortars. However, the transport properties decreased with the incorporation rate of SBR latex and the detrimental effect of SBR replacement was more pronounced in 20% SBR mortar mixtures.
A ROADMAP FOR BUILDING CLIMATE RESILIENCE AT HIGHER EDUCATION INSTITUTIONS: A CASE STUDY OF ARIZONA STATE UNIVERSITY
Authors: Campbell Hailey , Crippen Alise , Hawkey Corey , Dalrymple Mick 
Published: December 2020

ABSTRACT
Over the past few years, more and more higher education institutions have pledged to achieve carbon neutrality and designed and adopted Climate Action Plans. Although many higher institutions are adopting climate action plans, few are integrating resilience principles and priorities, which are essential for understanding institutions’ adaptive capacity for dealing with climate change. There is little existing research on how higher education institutions can implement climate resilience programs, behaviors, and policies into their planning process and campus-communities. To address this gap, this case study explores Arizona State University’s process of designing and implementing a climate resilience plan and outlines best practices other higher education institutions can utilize to create their own climate resilience plan. We critically discuss the importance of climate resilience at the higher education level, outline steps necessary for designing an inclusive and holistic climate resilience plan, and provide examples of important techniques used to design the climate resilience plan.
ENERGY EMBODIED IN, AND TRANSMITTED THROUGH, WALLS OF DIFFERENT TYPES WHEN ACCOUNTING FOR THE DYNAMIC EFFECTS OF THERMAL MASS
Authors: Reilly Aidan , Kinnane Oliver , O’Hegarty Richard 
Published: December 2020

ABSTRACT
Embodied energy is a measure of the energy used in producing, transporting and assembling the materials for a building. Operational energy is the energy used to moderate the indoor environment to make it functional or comfortable—primarily, to heat or cool the building. For many building geometries, the walls make the most significant contribution to the embodied energy of the building, and they are also the path of greatest heat loss or gain through the fabric, as they often have a greater surface area than the roof or floor. Adding insulation reduces the heat flow through the wall, reducing the energy used during operation, but this adds to the embodied energy. The operational energy is not only a function of the wall buildup, but also depends on the climate, occupancy pattern, and heating strategy, making an optimisation for minimum overall energy use non-trivial. This study presents a comparison of typical wall construction types and heating strategies in a temperate maritime climate. The transient energy ratio method is a means to abstract the heat flow through the walls (operational energy for heating), allowing assessment of the influence of walls in isolation (i.e. in a general sense, without being restricted to particular building geometries). Three retrofit scenarios for a solid wall are considered. At very low U-values, overall energy use can increase as the embodied energy can exceed the operational energy; current best practice walls coupled with low building lifetimes mean that this point may be reached in the near future. Substantial uncertainty is present in existing embodied energy data, and given its contribution to total energy use, this is a topic of urgent concern.
Les décembristes
Authors: Grandhaye Julie 
Published: December 2020

« Nous réclamons une constitution. • Telle est l’exhortation qu’une centaine d’officiers, rassemblés sur la place du Sénat à Saint-Pétersbourg le 14 décembre 1825, adresse à Nicolas 1er. La réponse du jeune empereur est à l’image de l’autocratie : arrestation, procès, puis condamnation à l’exil. Le destin des insurgés se poursuit en Sibérie : portant le nom de leur insurrection, les « décembristes » sont déportés pour avoir élevé la contestation en place publique.

Comment des officiers, loyaux soutiens de l’Empire, ont-ils pu prendre les armes contre leur souverain ? Le présent ouvrage se donne l’ambition de retracer l’itinéraire de ces hommes pour comprendre leur marche vers l’insurrection de 1825. Il s’appuie sur un corpus original et varié : archives familiales, correspondances, projets de constitution, interrogatoires et dossiers d’instruction, mémoires rédigés en exil. Ces sources nous dévoilent l’intimité d’une génération, née en terre d’autocratie, devenue républicaine.
L’impossible alliance ?
Authors: Sanderson Claire 
Published: December 2020

Alliées et rivales, entre entente et mésentente, la France et la Grande- Bretagne ont, dès la fin de la Seconde Guerre mondiale, une perception différente des principes de la mise en œuvre d’une politique de sécurité commune en Europe. De l’immédiat après-guerre à l’arrivée du général de Gaulle en 1958, cet ouvrage explique les divergences du couple franco-britannique sur la question de la défense de l’Europe occidentale. Tandis que la France se situe dans un contexte de construction européenne, la Grande- Bretagne, prenant progressivement conscience de l’effritement de son statut de grande puissance, privilégie la mise en œuvre de cette défense européenne dans un cadre de plus en plus atlantique. L’analyse des archives diplomatiques françaises et britanniques éclaire d’un jour nouveau la part de la responsabilité britannique dans l’échec de la Communauté européenne de défense, et les priorités divergentes de la Grande-Bretagne et de son voisin français. Du lendemain de la guerre aux nouvelles donnes stratégiques européennes apparues après la dissolution du bloc soviétique, les relations franco-britanniques ont traversé plusieurs décennies d’incompréhension mutuelle. Période charnière au cours de laquelle se dégagent les priorités en matière de défense européenne, les années 1945-1958 offrent un champ de recherche permettant d’identifier et d’analyser les racines de cette incompréhension.
Les ingénieurs des travaux publics et la transformation des métropoles américaines, 1870-1910
Authors: Harter Hélène 
Published: December 2020

À la fin du XIXe siècle au moment où la Révolution industrielle fait des États-Unis un pays tourné vers le progrès industriel et technique, un nouvel acteur s'impose sur la scène urbaine : l'ingénieur des travaux publics. Grâce aux équipements qu’il réalise, les métropoles se transforment radicalement. La modernisation des réseaux d’eau et des égouts fait reculer les épidémies, la création d'espaces verts améliore le cadre de vie, tandis que la construction d'ouvrages d'art, comme le pont de Brooklyn à New York, facilite la circulation. L'aptitude à l’innovation des ingénieurs municipaux américains est telle qu'ils deviennent des références en matière de travaux publics, en Amérique, mais aussi en Europe. S'intéresser à leur œuvre permet donc de mieux comprendre comment les États-Unis devienne à la fin du XIXe siècle une puissance technique de premier plan. L'influence de ces ingénieurs ne se limite pas cependant aux seules questions techniques. En effet, en recrutant ces hommes, les métropoles américaines posent les bases d'un gouvernement par l'expertise qui sera largement plébiscité au XXe siècle. On est loin de l'image corrompue qui est généralement associée aux villes à celle époque. En analysant le rôle des ingénieurs municipaux, c'est en fait les réalités urbaines de la fin du XIXe siècle que nous cernons mieux.
Le péronisme
Authors: Guillerm Gérard 
Published: December 2020

Argentine, 1955-1989 : environ trente cinq ans d’histoire, au travers de la propre histoire de ce mouvement politique - le Péronisme - qui malgré (ou en raison) de ses multiples avatars, demeure la force incontournable sans laquelle l’avenir argentin ne peut sérieusement être envisagé. L’auteur tente ici cette gageur de restituer, avec rigueur, honnêteté et en refusant les a-priori, les principaux épisodes et faits marquants de cette histoire : le rôle de cette figure mythique que fut Evita ; le coup d’Etat de septembre 1955 contre Peron ; l’essai de John William Cooke de créer un grand mouvement de résistance à la Junte militaire ; le pacte Peron-Frondizi ; le « jeu » entre le général Lanusse et l’exilé de Madrid ; l’échec de la tentative d’instaurer, sous Hector Campora, un « Péronisme socialiste » ; la Présidence de la troisième épouse, Isabelita, dominée par le personnage raspoutinien Lopez Rega ; le désastre du régime militaire après le coup d’Etat de 1976 ; la guerre des Malouines ; le rétablissement de la démocratie avec l’élection d’Alfonsin ; le grave échec économique du gouvernement radical. Ce livre, en définitive, n’a d’autre ambition (car il s’agit d’une « chronique ») que d’apporter sa contribution à une meilleure connaissance d’un mouvement politique qui a toujours fortement oscillé entre ses extrêmes, et qui cherche, aujourd’hui, à occuper une position « centrale » sur l’échiquier politique argentin. Le Péronisme aurait pu donner le meilleur. Il a parfois le pire. Peut-il, à présent, apporter à l’Argentine ce dont elle a besoin : un peu plus que l’« acceptable » ? Et demain, sera-t-il capable de promouvoir cet « humanisme tempéré » que mérite l’Argentine et dont parle Tzvetan Todorov dans son livre « Nous et les autres » ? En définitive, réussira-t-il à « dépasser » Peron ? Cette question, pour l’instant, ne peut rester que sans réponse.
Peningkatan Motorik Kasar Anak Usia 4-5 Tahun Melalui Permainan Tradisional Sondah Gunung (Engklek)
Authors: Aziz M Taufik , Susam Tia 
Published: December 2020

Kindergarten (TK) or Raudatul Atfal (RA) children are generally very active, they have mastery over their bodies and really like doing activities on their own. Therefore, parents or teachers need to provide space and time for children to do activities that can train the child's gross muscles as well as provide items and equipment for children that can be pushed, lifted, thrown or carried. Teachers must also be creative in seeing learning models that can attract children's interest in learning.
Traditional games are a wealth of the Indonesian nation. One of these types of traditional games, namely sondah gunung or crank, is a favorite game for children because it can be played by boys or girls. In the crank game there is a value for good physical development which is reflected in the crank game which requires whole body movements, namely lifting one leg, moving the body and hands. By doing these activities, it means that the child has carried out activities for sports, especially in gross motor movements, namely throwing, jumping, jumping, and standing on one leg. Apart from that, the mountain skating game can improve coordination and body balance and develop children's skills. All of which aim to help the child's growth.
The implementation of gross motor learning activities for children aged 4-5 years with the traditional game of sondah gunung (crank) at RA Miftahul Jannah, Bogor City that has been implemented can significantly improve children's motor skills. The research was conducted with 1 pre-research activity and 2 research cycles with a total of 7 meetings. This is evidenced by an increase in the average in each assessment, namely in the pre-test the average motoric ability of children is 47.36%, then in cycle 1 it is 71.23% and in cycle 2 it is 86.54%. The average percentage increase from pretest to posttest in cycle 1 was 23.85%. The percentage of average increase from posttest in cycle 1 to posttest cycle 2 was 15.21%. So the average percentage increase from pretest to posttest cycle 2 is (23, 85% + 15, 21%) = 39, 06%.