bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Ideal Thermal Settings for Administration Office on Hot-Humid Climate
Authors: Salsabila N D , Ibrahim N H. , Syahirani T N T , Tanzil Y T , Dewi O C 
Published: June 2020

Abstract
Thermal conditions in Administration Room, Department of Architecture, Universitas Indonesia were taken as case studies to understand the ideal thermal settings for occupants in the administration office with hot-humid climate. The investigation aims to visualize the indoor environmental quality of the office room in-terms of temperature and humidity and obtain the perceptions of occupants regarding their satisfaction toward the evaluation of thermal comfort for office space. On-site measurements of air temperature and relative humidity for objective data, as well as questionnaire for subjective data, were applied to obtain occupants’ responses on the thermal quality of the office. The correlation between objective and subjective data that shows the thermal comfort level influenced the working environment. The study found that most of the time, the occupants of the room feel slightly cold rather than satisfied with their thermal environment settings. The data further show that the comfortable temperature this Administration room around 26-28°C and RH from about 50-60%.
Sustainable Hybrid Village: Regeneration of Settlement in Jatinegara, Indonesia
Authors: Endangsih T , Prayitno B , Kusumawanto A 
Published: June 2020

Abstract
Over the past few decades, cities have experienced severe social and economic pressures, which have a disproportionate impact on the urban environment. As a result, the quality environment has decreased, which is characterized by increased CO2 emissions and energy operating costs. Sustainable city development is considered as a step to create a pleasant environment for the community. Therefore, this research is essential to do to regenerate settlements in improving urban quality. This study aims to find a model for developing sustainable hybrid settlements in densely populated areas. The research method with the simulation method uses the Urban Modeling Interface device with three parameters. The modeling results obtained a Floor Area Ratio (FAR) value of 0.43 with a total land area of ± 427,233 m2. The FAR value produces an operational energy value of 3,983kwh / m2 / year and an embodied energy value of 216 kWh / m2 / year. This value is very high from 240 kWh / m2 / year as a standard for energy use. The amount of mobility in the aspect of walkability is 21-68, and 21-69 for the value of Bikeability. The results of this simulation indicate that the residential area in Jatinegara is not yet sustainable.
Efficiency Energy on Office Building in South Jakarta
Authors: Amalia M , Paramita B , Minggra R , Koerniawan M D 
Published: June 2020

Abstract
South Jakarta is the center of business in Indonesia. As a business center, energy consumption in office buildings in South Jakarta is very high. An office building can consume energy up to 250 kWh/m2/yr. Energy consumption can be analyzed using building performance applications such as Sefaira. Sefaira is used as a method to simulate building energy that allows energy to be efficiently utilized. An energy analysis study was conducted to determine energy efficiency in an office building. The standards and guidelines of energy efficiency are based on ASHRAE 90.1 – 2013 on Sefaira. Efficiency energy is needed to achieve the Sefaira 2030 energy target of 90 kWh/m2/yr. In the previous analysis, the building consumed energy of 186 kWh/m2/yr. Architectural treatment on the building facades is needed, such as providing canopies, double-skin facades, and materials to reduce energy consumption by 96 kWh/m2/yr.
Pedestrian-Friendly for Redesign Leuwipanjang Integrated Terminal with Wayfinding Approach
Authors: Hanissa A N , Paramita B , Megayanti T , Koerniawan M D 
Published: June 2020

Abstract
This research is about the importance of user comfort in Leuwipanjang terminal, especially pedestrians, while in it. Leuwipanjang Terminal is a type A bus terminal in Bandung which will be one of the 14 proposed Transit-Oriented Development (TOD) planning points. The terminal controls the movement of traffic, namely pedestrian and vehicle traffic. Integrated Terminal Planning at Leuwipanjang Bus Terminal will accommodate many types of transportation modes so that there is an overlapping circulation when switching between modes. While passengers who have just arrived at the terminal usually feel confused to find a destination. The Leuwipanjang terminal does not currently provide clarity on circulation and does not give a pedestrian way. So Leuwipanjang terminal is needed to redesign, pedestrian-friendly terminal by providing safe and comfortable direct access to all the characteristics of users at the terminal.
The prototypes of energy-efficient residential Building with metal roof in Gorontalo, Indonesia
Authors: Jahja M , Gunawan A , Syamsul A N F , Arifin Y I , Koerniawan M D 
Published: June 2020

Abstract
To optimize Gorontalo’s residential building design to a sequential search technique is being used to minimize their life-cycle energy cost while improving their energy efficiency. Certain design features are included like air-conditioned, house orientation, window material, wall exterior finish, roof insulation, lighting fixtures, cooling system efficiencies, and photovoltaic while also considering the neighbor displacement. The outcomes of the sequential search methodology are contrasted with those achieved through a more time-consuming approach to brute-force optimization. Alternatively, for selected locations in Gorontalo, the best design features for residential building is determined. By using specific measures resulted from the optimization technique can cost-effectively reduce the annual energy saving by 59%, while adding the photovoltaic as a measure, we can increase the annual energy use saving percentage up to 117% compared to the reference design in the residential building in Gorontalo.
Sustainability Potential for Renewable Energy System in Isolated Area that Supports Nantu Boliyohuto Wildlife Reserve
Authors: Pontoiyo F , Sulaiman M , Budiarto R , Novitasari D 
Published: June 2020

Abstract
It is still a challenging task to fulfill power demand of Tumba Hamlet in Tamaila Utara Village, which is an isolated area in the buffer zone of Nantu Boliyohuto Wildlife Reserve. The efforts to fulfill the demand had been carried out by the local government by distributing the Solar Home System (SHS) to all households in 2013. However, the SHS performance quickly declined because the solar panels in the rooftop covered by dense and lush trees, and then it did not work at all in 2018. This research performs pre-feasibility in building the micro-hydro powerplant (MHPP) and its sustainability potential in Tumba Hamlet to fulfill the community’s electrical energy needs without disrupting the Nantu Boliyohuto Wildlife Reserve. A basic survey was performed in exploring river resources and topographical conditions in this hamlet. Sustainability study, including technical, social, and environmental aspects, was conducted by interviewing the residents. The results show that the power needs in Tumba Hamlet are 48.5 kW. This demand can be fulfilled by the MHPP with head and water discharge of 10 meters and 0.706 m3/s, respectively. It was found that positive feedback in the technical, social, and environmental aspects of sustainability is dominant.
Gaussian mixture model-based unsupervised nucleotide modification number detection using nanopore-sequencing readouts
Authors: Ding Hongxu , Bailey Andrew D , Jain Miten , Olsen Hugh , Paten Benedict 
Published: June 2020

Abstract

Motivation
Nucleotide modification status can be decoded from the Oxford Nanopore Technologies nanopore-sequencing ionic current signals. Although various algorithms have been developed for nanopore-sequencing-based modification analysis, more detailed characterizations, such as modification numbers, corresponding signal levels and proportions are still lacking.

Results
We present a framework for the unsupervised determination of the number of nucleotide modifications from nanopore-sequencing readouts. We demonstrate the approach can effectively recapitulate the number of modifications, the corresponding ionic current signal levels, as well as mixing proportions under both DNA and RNA contexts. We further show, by integrating information from multiple detected modification regions, that the modification status of DNA and RNA molecules can be inferred. This method forms a key step of de novo characterization of nucleotide modifications, shedding light on the interpretation of various biological questions.

Availability and implementation
Modified nanopolish: https://github.com/adbailey4/nanopolish/tree/cigar_output. All other codes used to reproduce the results: https://github.com/hd2326/ModificationNumber.

Supplementary information
Supplementary data are available at Bioinformatics online.
Loss of myosin VI expression affects acrosome/acroplaxome complex morphology during mouse spermiogenesis†
Authors: Zakrzewski Przemysław , Rędowicz Maria Jolanta , Buss Folma , Lenartowska Marta 
Published: June 2020

AbstractDuring spermiogenesis in mammals, actin filaments and a variety of actin-binding proteins are involved in the formation and function of highly specialized testis-specific structures. Actin-based motor proteins, such as myosin Va and VIIa, play a key role in this complex process of spermatid transformation into mature sperm. We have previously demonstrated that myosin VI (MYO6) is also expressed in mouse testes. It is present in actin-rich structures important for spermatid development, including one of the earliest events in spermiogenesis—acrosome formation. Here, we demonstrate using immunofluorescence, cytochemical, and ultrastructural approaches that MYO6 is involved in maintaining the structural integrity of these specialized actin-rich structures during acrosome biogenesis in mouse. We show that MYO6 together with its binding partner TOM1/L2 is present at/around the spermatid Golgi complex and the nascent acrosome. Depletion of MYO6 in Snell’s waltzer mice causes structural disruptions of the Golgi complex and affects the acrosomal granule positioning within the developing acrosome. In summary, our results suggest that MYO6 plays an anchoring role during the acrosome biogenesis mainly by tethering of different cargo/membranes to highly specialized actin-related structures.
HIV, progestins, genital epithelial barrier function, and the burden of objectivity†
Authors: Vicetti Miguel Rodolfo D , Quispe Calla Nirk E , Cherpes Thomas L 
Published: June 2020

Abstract
Contributions from a diverse set of scientific disciplines will be needed to help individuals make fully informed decisions regarding contraceptive choices least likely to promote HIV susceptibility. This commentary recaps contrasting interpretations of results from the Evidence for Contraceptive Options and HIV Outcomes (ECHO) Trial, a study that compared HIV risk in women using the progestin-only injectable contraceptive depot medroxyprogesterone acetate (DMPA) vs. two other contraceptive choices. It also summarizes results from basic and translational research that establish biological plausibility for earlier clinical studies that identified enhanced HIV susceptibility in women using DMPA.
Cytogenetic diversity in the polyploid complexLinum suffruticosum s.l. (Linaceae)
Authors: Afonso Ana , Loureiro João , Arroyo Juan , Olmedo-Vicente Erika , Castro Sílvia 
Published: June 2020

AbstractPolyploidy plays a significant role in the evolution and diversification of flowering plants. In several polyploid complexes, high morphological variability and plasticity coupled with cytogenetic diversity make it difficult to disentangle their evolutionary history. The main goal of this study was to gain insights into the role of whole genome duplications as one of the factors shaping the evolution of flowering plants. Linum suffruticosum s.l. has been described as a polyploid complex, with high morphological variability, but nothing is known about current cytogeographical patterns. We investigated cytotype diversity and distribution patterns in 151 populations covering most of the distribution range, in the Iberian Peninsula, south-eastern France, north-western Italy and Morocco, using flow cytometric analyses complemented with chromosome counts. A high cytogenetic diversity was found with five major cytotypes being detected (diploids, tetraploids, hexaploids, octoploids and decaploids) and with new ploidy levels being reported for the first time. The different ploidies were distributed parapatrically, with geographical structure and several contact zones. Most of the populations comprised one cytotype, but a few mixed-ploidy populations were observed. Our results suggest that whole genome duplications are one of the key mechanisms, alone or together with hybridization, governing the diversification of L. suffruticosum s.l. Genome size and/or chromosome counts might be useful tools for identifying specimens of L. suffruticosum s.l. Also, geographical overlap and high cytogenetic diversity suggest multiple origins of the polyploids. The diversity observed here has been mostly neglected to date and should be accounted when studying the biosystematics of this complex.
Central bankers and the rationale for unconventional monetary policies: reasserting, renouncing or recasting monetarism?
Authors: Fiebiger Brett , Lavoie Marc 
Published: June 2020

Abstract
The purpose of this paper is to examine the rationale for the unconventional monetary policies adopted by central banks in response to the Global Financial Crisis. Quantitative easing appears to be a return to monetarist principles. Indeed, the Bank of England emphasised a causal chain running from increases in broad money to spending and inflation, while the Bank of Japan later pointed to a theorised relation between base money and expected inflation. Some aspects of monetarism have been renounced, albeit not necessarily with convincing reasoning. Monetarist principles can also be discerned in the ‘credit view’ associated with the research of two-term US Federal Reserve Chair, Ben Bernanke. An understanding of the banking system and the channels of monetary transmission is still a work in progress.
Novel non-cystic features of polycystic kidney disease: having new eyes or seeking new landscapes
Authors: Van Laecke Steven , Van Biesen Wim 
Published: June 2020

AbstractFor decades, researchers have been trying to decipher the complex pathophysiology of autosomal dominant polycystic kidney disease (ADPKD). So far these efforts have led to clinical trials with different candidate treatments, with tolvaptan being the only molecule that has gained approval for this indication. As end-stage kidney disease due to ADPKD has a substantial impact on health expenditures worldwide, it is likely that new drugs targeting kidney function will be developed. On the other hand, recent clinical observations and experimental data, including PKD knockout models in various cell types, have revealed unexpected involvement of many other organs and cell systems of variable severity. These novel non-cystic features, some of which, such as lymphopenia and an increased risk to develop infections, should be validated or further explored and might open new avenues for better risk stratification and a more tailored approach. New insights into the aberrant pathways involved with abnormal expression of PKD gene products polycystin-1 and -2 could, for instance, lead to a more directed approach towards early-onset endothelial dysfunction and subsequent cardiovascular disease. Furthermore, a better understanding of cellular pathways in PKD that can explain the propensity to develop certain types of cancer can guide post-transplant immunosuppressive and prophylactic strategies. In the following review article we will systematically discuss recently discovered non-cystic features of PKD and not well-established characteristics. Overall, this knowledge could enable us to improve the outcome of PKD patients apart from ongoing efforts to slow down cyst growth and attenuate kidney function decline.
Systematic Review of Curriculum-Based Measurement with Students Who Are Deaf
Authors: Lam Elizabeth A , McMaster Kristen L , Rose Susan 
Published: June 2020

Abstract
This review systematically identified and compared the technical adequacy (reliability and validity evidence) of reading curriculum-based measurement (CBM) tasks administered to students who are deaf and hard of hearing (DHH). This review included all available literature written in English. The nine studies identified used four CBM tasks: signed reading fluency, silent reading fluency, cloze (write in missing words given blank lines within a passage), and maze (circle the target word given multiple choice options within a passage). Data obtained from these measures were generally found to be internally consistent and stable with validity evidence varying across measures. Emerging evidence supports the utility of CBM for students who are DHH. Further empirical evidence is needed to continue to explore technical properties, identify if student scores are sensitive to growth over short periods of time, and examine whether CBM data can be used to inform instructional decision-making to improve student outcomes.
Goodnight Gorilla: Deaf Student American Sign Language Narrative Renditions After Viewing a Model
Authors: Beal Jennifer S , Scott Jessica A , Spell Kelly 
Published: June 2020

AbstractThe present study used an observational learning framework to investigate changes in non-native signing deaf children’s narrative renditions before (Time 1) and after (Time 2) a single viewing of a signing adult’s rendition of the same story. The deaf adult model rendered the picture book Goodnight Gorilla in American Sign Language (ASL) with the pages of the book displayed behind her. We analyzed the details children aged 6–13 years included within their narratives and how they rendered those details. Specifically, we compared their use of depicting constructions (DCs), constructed action (CA), simultaneous use of both DCs and CA, and only lexical signs before and after viewing the model. The deaf adult predominantly and equally used CA and constructed actin paired with DCs and rarely used lexical signs alone during her rendition. After watching the adult rendition, children’s renditions were longer and they included more details. Children increased their use of DCs, CA, and to a lesser extent, combinations of DCs and CA. However, half of the children never used DCs paired with CA. Suggestions for pairing ASL content standards with viewings of deaf adult sign language models are discussed.
Binary classification with covariate selection through ℓ0-penalised empirical risk minimisation
Authors: Chen Le-Yu , Lee Sokbae 
Published: June 2020

Summary
We consider the problem of binary classification with covariate selection. We construct a classification procedure by minimising the empirical misclassification risk with a penalty on the number of selected covariates. This optimisation problem is equivalent to obtaining an ℓ0-penalised maximum score estimator. We derive probability bounds on the estimated sparsity as well as on the excess misclassification risk. These theoretical results are nonasymptotic and established in a high-dimensional setting. In particular, we show that our method yields a sparse solution whose ℓ0-norm can be arbitrarily close to true sparsity with high probability and obtain the rates of convergence for the excess misclassification risk. We implement the proposed procedure via the method of mixed-integer linear programming. Its numerical performance is illustrated in Monte Carlo experiments and a real data application of the work-trip transportation mode choice.
Prognostic impact of transcatheter mitral valve repair in patients with exercise-induced secondary mitral regurgitation
Authors: Izumo Masaki , Kuwata Shingo , Ishibashi Yuki , Suzuki Tomomi , Ohara Hiroshi , Watanabe Mika , Sato Yukio , Nishikawa Haruka , Okuyama Kazuaki , Kamijima Ryo , Takai Manabu , Kou Seisyo , Harada Tomoo , Akashi Yoshihiro J 
Published: June 2020

Abstract

Aims
Although exercise-induced secondary mitral regurgitation (MR) is known to have a poor prognosis, the therapeutic strategy towards this condition remains to be investigated. In the present study, we aimed to investigate the prognostic impact of transcatheter mitral valve repair (TMVr) using the MitraClip in patients with exercise-induced secondary MR.

Methods and results
Of the 200 consecutive patients with secondary MR who underwent exercise stress echocardiography, 46 (23%) that presented with exercise-induced secondary MR [i.e. increase in effective regurgitant orifice area (EROA) of ≥ 0.13 cm2] were enrolled in the present investigation. The composite endpoints of all-cause mortality and hospitalization for heart failure were evaluated. Of the 46 patients included in the current cohort, 19 (41%) underwent TMVr and 27 (59%) were medically managed (control group). Although the TMVr group tended to present with a greater EROA at rest (0.26 ± 0.10 vs. 0.20 ± 0.08 cm2, P = 0.047), there were no differences in the EROA changes during exercise between the two groups (0.18 ± 0.10 vs. 0.18 ± 0.04 cm2, P = 0.940). While the TMVr group reported a higher event-free survival rate after the 13-month follow-up period (log-rank P = 0.017), the Cox proportional-hazard analysis suggested the TMVr to be associated with clinical outcomes (hazard ratio: 0.419, P = 0.044).

Conclusion
As opposed to the medical management, TMVr treatment was associated with a lower risk of composite endpoints in patients with exercise-induced secondary MR. Exercise stress echocardiography is considered to have played an important role in decision-making for secondary MR.
Public Capital and Economic Development
Authors: Cubas German 
Published: June 2020

AbstractPublic capital is sizable and its share in total capital is higher in poor countries. The standard development accounting approach does not distinguish it from private capital, ignoring its public good features. The goal of this paper is to measure public capital stocks for a wide range of countries, and then develop and implement a development accounting framework that explicitly includes its non-rival aspects. The paper finds that factors of production account for a significantly greater share of cross-country differences in output per worker compared to the standard framework. With both non-rivalry and congestion, the contribution of factors of production decreases.