bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-modal liquid biopsy platform for cancer screening: screening both cancer-associated rare cells and cancer cell-derived vesicles on the fabric filters for a reliable liquid biopsy analysis
Authors: Bu Jiyoon , Shim Jae-Eul , Lee Tae Hee , Cho Young-Ho 
Published: November 2019

AbstractCirculating tumor cells (CTCs) are receiving a great amount of scientific interest as a diagnostic biomarker for various types of cancer. Despite the recent progress in the development of highly sensitive CTC isolation devices, post-capture analysis of CTCs is still hindered by technical challenges associated with their rarity. Herein, we present a multi-modal CTC screening platform which is capable to analyze CTCs and CTC-derived extracellular vesicles (EVs), simultaneously from a single sample. Cytochalasin B (CB) treatment promotes cells to release large number of EVs from their surface, as demonstrated by CB-treated cells (5 µg/mL for 3 h) secreting 3.5-fold more EVs, compared to the non-treated cells. CB further generates 1.7-fold more EVs from the cells captured on our CTC filtration device (the fabric filter), compared to those from the cell culture flasks, owing to its multiple pore structure design which reduces the non-specific binding of EVs. Both CB-treated cancer cells and CB-induced EVs are found to overexpress tumor-associated markers, demonstrating a potential for the development of CTC dual-screening platform. Collectively, the results presented in this study reveal that our multi-modal cancer screening platform can synergistically improve the reliability and efficacy of the current CTC analysis systems.
Diffusion-weighted imaging for identifying patients at high risk of tumor recurrence following liver transplantation
Authors: Chuang Yi-Hsuan , Ou Hsin-You , Yu Chun-Yen , Chen Chao-Long , Weng Ching-Chun , Tsang Leo Leung-Chit , Hsu Hsien-Wen , Lim Wei-Xiong , Huang Tung-Liang , Cheng Yu-Fan 
Published: November 2019

Abstract
Background
Tumor recurrence is the major risk factor affecting post-transplant survival. In this retrospective study, we evaluate the prognostic values of magnetic resonance (MR) diffusion-weighted imaging (DWI) in liver transplantation for hepatocellular carcinoma (HCC).

Methods
From April 2014 to September 2016, 106 HCC patients receiving living donor liver transplantation (LDLT) were enrolled. Nine patients were excluded due to postoperative death within 3 months and incomplete imaging data. The association between tumor recurrence, explant pathologic findings, and DWI parameters was analyzed (tumor-to-liver diffusion weighted imaging ratio, DWIT/L; apparent diffusion coefficients, ADC). The survival probability was calculated using the Kaplan–Meier method.

Results
Sixteen of 97 patients (16%) developed tumor recurrence during the follow-up period (median of 40.9 months; range 5.2–56.5). In those with no viable tumor (n = 65) on pretransplant imaging, recurrence occurred only in 5 (7.6%) patients. Low minimum ADC values (p = 0.001), unfavorable tumor histopathology (p <  0.001) and the presence of microvascular invasion (p <  0.001) were risk factors for tumor recurrence, while ADCmean (p = 0.111) and DWIT/L (p = 0.093) showed no significant difference between the groups. An ADCmin ≤ 0.88 × 10− 3 mm2/s was an independent factor associated with worse three-year recurrence-free survival (94.4% vs. 23.8%) and overall survival rates (100% vs. 38.6%).

Conclusions
Quantitative measurement of ADCmin is a promising prognostic indicator for predicting tumor recurrence after liver transplantation.
In vivo and in vitro pharmacological activities of Tacca integrifolia rhizome and investigation of possible lead compounds against breast cancer through in silico approaches
Authors: Ahmed Shahriar , Rakib Ahmed , Islam Md. Ashiqul , Khanam Bibi Humayra , Faiz Farhana Binta , Paul Arkajyoti , Chy Md. Nazim Uddin , Bhuiya N. M. Mahmudul Alam , Uddin Mir Muhammad Nasir , Ullah S. M. Amanat , Rahman Md. Atiar , Emran Talha Bin 
Published: November 2019

Abstract
Background
The study was conducted to evaluate the analgesic, anti-inflammatory, antipyretic properties of ethanolic extract of Tacca integrifolia rhizome (EETI) in mice and cytotoxic effects in brine shrimp nauplii followed by a PASS prediction study for some isolated compounds of T. integrifolia. Additionally, this experiment included the in silico molecular docking and ADME/T property analyses of some phytochemicals.

Methods
Formalin- induced paw licking test and acetic acid-induced writhing test for analgesic activity, carrageenan-induced paw edema test for anti-inflammatory potential and Brewer’s yeast-induced pyrexia test for antipyretic activity were applied. Antinociceptive and antineoplastic activity for breast cancer were revealed with PASS program. Schrodinger suite 2015 was used to evaluate the binding interaction and ADME/T properties of selected phytoconstituents with estrogen receptor alpha.

Results
In formalin-induced paw licking test, EETI at the doses of 200 and 400 mg/kg BW showed highly significant inhibition of writhing in both neurogenic and inflammatory phases. While EETI also exhibited highly significant, compared to control, writhing inhibition for both the doses in acetic acid-induced writhing test. Moderate anti-inflammatory effect at a dose of 400 mg/kg BW was noticed in paw-edema test. It also showed 77.51% of maximum antipyretic effect which was significantly effective compared to standard drug paracetamol (150 mg/kg) in Brewer’s yeast-induced pyrexia test. The EETI showed potential cytotoxic activity with LC50 value of 114.46 μg/mL. The PASS prediction revealed the potential antinociceptive and antineoplastic activity of target compounds. The compounds betulinic acid, quercetin-3-α-arabinoside, catsanogenin were found to be effective in molecular docking study.

Conclusion
It is evident that the EETI possesses highly significant analgesic activity with remarkable anti-inflammatory and antipyretic activity. The phytoconstituents have potential antinociceptive and antineoplastic (breast cancer) activity.

Graphical abstract
Compelling therapy of LVH: straight (and not-so-straight) inferences from evidence
Authors: Mehta Ravi Tejraj , Pareek Anil , Dharmadhikari Shruti 
Published: November 2019

AbstractWe have read with interest the Korean Society of Hypertension guidelines for the management of hypertension and congratulate the Society for an extensive review of literature while drafting the guidelines. The guidelines indicate preferring ACE-I and CCB over diuretics in patients with left ventricle hypertrophy. However, in landmark head-to-head comparison trials, the thiazide-like diuretic chlorthalidone has been shown to be superior to ACE-I and CCB in decreasing left ventricle mass and preventing heart failure in hypertensive patients. Also, we put forth the paradoxical finding that mere regression of LVH may not always translate into reduction in risk of HF; and that the pleiotropic effects of chlorthalidone may be the explanation behind its beneficial action in HF.
A review on the definitions of terms of sedimentary facies
Authors: Feng Zeng-Zhao 
Published: November 2019

AbstractIn recent years, in some papers and manuscripts published in and submitted to the Journal of Palaeogeography (Chinese Edition and English Edition), the authors named the rocks or rock types as “microfacies” or “lithofacies”, named the microfeatures in thin-sections under microscope as “microfacies”, and named the macrofeatures of rocks as “macrofacies”. I wrote two short papers “Words of the Editor-in-Chief — Rocks are not microfacies” (Feng, Journal of Palaeogeography 19(5):II 2017) and “Words of the Editor-in-Chief — Rocks are not lithofacies” (Feng, Journal of Palaeogeography 20(3):452–452, 2018) which were in Chinese and published in the Journal of Palaeogeography (Chinese Edition). However, they did not attract much attention of readers in China and outside China. In addition, in 1980s, some Chinese sedimentologists proposed “subfacies” and “microfacies” based on the macrofeatures of rocks from outcrops and drilling cores. However, the definition of this “microfacies” is totally different from the “microfacies” proposed by foreign sedimentologists in 1940s based on the microfeatures in thin-sections under microscope.These problems appeared repeatedly and forced me, as the Editor-in-Chief of the Journal of Palaeogeography (Chinese Edition and English Edition), to observe the policy of “A hundred flowers blossom and a hundred schools of thought contend” , to write new papers “A review on the definitions of terms of sedimentary facies” both in Chinese and in English, to clarify the definitions of the terms of sedimentary facies, i.e., “facies”, “lithofacies”, two “microfacies”, “macrofacies”, “subfacies”, etc. I hope that the new papers will attract attention of readers worldwide and they can write papers and participate in the discussion and contending of these problems, strive for getting some common understandings, and therefore promote the progress and development of sedimentology and palaeogeography.
Imaging vertical structures using Marchenko methods with vertical seismic-profile data
Authors: Lomas Angus , Singh Satyan , Curtis Andrew 
Published: November 2019

Marchenko methods use seismic data acquired at or near the surface of the earth to estimate seismic signals as if the receiver (now a virtual receiver) was at an arbitrary point inside the subsurface of the earth. This process is called redatuming, and it is central to subsurface imaging. Marchenko methods estimate the multiply scattered components of these redatumed signals, which is not the case for most other redatuming techniques that are based on single-scattering assumptions. As a result, images created using Marchenko redatumed signals contain a reduction in the artifacts that usually contaminate migrated seismic images due to improper handling of internal multiples. We exploit recent theoretical advances that enable virtual sources and virtual receivers to be placed at arbitrary points inside the subsurface as a means to incorporate vertical seismic profile (VSP) data into Marchenko methods. The advantage of including this type of data is that the additional acquisition boundary increases subsurface illumination, which in turn enables vertical interfaces and steeply dipping structures to be imaged. We develop this methodology using two synthetic data sets. The first is created using a simple variable density but constant velocity subsurface model. In this example, we find that our newly devised VSP Marchenko imaging methodology enables imaging of horizontal and vertical structures and that optimal results are achieved by combining these images with those created using standard Marchenko imaging. A second example demonstrates that the method can be applied to more realistic subsurface structures, in this case a modified version of the Marmousi 2 model. We determine the applicability of the methods to image fault structures with the final imaging result containing reduced contamination due to internal multiples and an improvement in the imaging of fault structures when compared to other standard imaging methods alone.
Yoga for psychiatric disorders: from fad to evidence-based intervention?
Authors: Varambally Shivarama , George Sanju , Gangadhar Bangalore Nanjundaiah 
Published: November 2019

SummaryThere is growing evidence for yoga's neurobiological effects in people with psychiatric disorders. Postulated mechanisms of action include: (a) modulation of the hypothalamic–pituitary–adrenal (HPA) axis; (b) enhancement of GABAergic neurotransmission; (c) autonomic modulation; and (d) neuroendocrinological effects. Yoga as a therapeutic intervention in psychiatric disorders appears promising and merits further attention in clinical practice and research.
Identifying ERBB2 Activating Mutations in HER2-Negative Breast Cancer: Clinical Impact of Institute-Wide Genomic Testing and Enrollment in Matched Therapy Trials
Authors: Exman Pedro , Garrido-Castro Ana C. , Hughes Melissa E. , Freedman Rachel A. , Li Tianyu , Trippa Lorenzo , Bychkovsky Brittany L. , Barroso-Sousa Romualdo , Di Lascio Simona , Mackichan Colin , Lloyd Max R. , Krevalin Max , Cerami Ethan , Merrill Margaret S. , Santiago Rebecca , Crowley Lindsey , Kuhnly Nicole , Files Janet , Lindeman Neal I. , MacConaill Laura E. , Kumari Priti , Tolaney Sara M. , Krop Ian E. , Bose Ron , Johnson Bruce E. , Ma Cynthia X. , Dillon Deborah A. , Winer Eric P. , Wagle Nikhil , Lin Nancy U. 
Published: November 2019

PURPOSE The yield of comprehensive genomic profiling in recruiting patients to molecular-based trials designed for small subgroups has not been fully evaluated. We evaluated the likelihood of enrollment in a clinical trial that required the identification of a specific genomic change based on our institute-wide genomic tumor profiling. PATIENTS AND METHODS Using genomic profiling from archived tissue samples derived from patients with metastatic breast cancer treated between 2011 and 2017, we assessed the impact of systematic genomic characterization on enrollment in an ongoing phase II trial (ClinicalTrials.gov identifier: NCT01670877 ). Our primary aim was to describe the proportion of patients with a qualifying ERBB2 mutation identified by our institutional genomic panel (OncoMap or OncoPanel) who enrolled in the trial. Secondary objectives included median time from testing result to trial registration, description of the spectrum of ERBB2 mutations, and survival. Associations were calculated using Fisher’s exact test. RESULTS We identified a total of 1,045 patients with metastatic breast cancer without ERBB2 amplification who had available genomic testing results. Of these, 42 patients were found to have ERBB2 mutation and 19 patients (1.8%) were eligible for the trial on the basis of the presence of an activating mutation, 18 of which were identified by OncoPanel testing. Fifty-eight percent of potentially eligible patients were approached, and 33.3% of eligible patients enrolled in the trial guided exclusively by OncoPanel testing. CONCLUSION More than one half of eligible patients were approached for trial participation and, significantly, one third of those were enrolled in NCT01670877. Our data illustrate the ability to enroll patients in trials of rare subsets in routine clinical practice and highlight the need for these broadly based approaches to effectively support the success of these studies.
Low Circulating Levels of miR-451a in Girls with Polycystic Ovary Syndrome: Different Effects of Randomized Treatments
Authors: Díaz Marta , Bassols Judit , López-Bermejo Abel , de Zegher Francis , Ibáñez Lourdes 
Published: November 2019

Abstract

Context
Polycystic ovary syndrome (PCOS) is a prevalent disorder in adolescent girls, purportedly driven by hepato-visceral fat excess, and often followed by subfertility and type 2 diabetes.

Objective
We studied the baseline microRNA (miRNA) profile of girls with PCOS, and the effects of a randomized treatment with an oral contraceptive (OC) or with spironolactone–pioglitazone–metformin (SPIOMET, aiming at loss of hepato-visceral fat excess) for 1 year.

Design & Patients
The miRNA profile was assessed by RNA sequencing in girls with PCOS who had participated in a randomized, open-label, single-center, pilot study (n = 31; age 15.7 years, body mass index (BMI) 23.1 kg/m2). Healthy age- and BMI-matched girls (n = 13) served as controls. Differentially expressed miRNAs were validated by RT-qPCR in the entire study population. Post-treatment ovulation rates were assessed by salivary progesterone in PCOS girls.

Setting
Endocrinology Department, University Hospital.

Results
Girls with PCOS, compared with controls, had markedly reduced concentrations of circulating miR-451a, miR-652-3p, miR-106b-5p, and miR-206; pathway enrichment analysis showed that these miRNAs target genes involved in energy homeostasis and cell cycle control. In the present study, miR-451a could diagnose PCOS with 100% sensitivity and 100% specificity. SPIOMET (but not OC) was accompanied by on-treatment normalization of the miRNA profile in girls with PCOS; miR-451a concentrations after 1 year on OC or SPIOMET treatment associated closely (r = 0.66; P &lt; .0001) with post-treatment ovulation rates.

Conclusion
SPIOMET treatment for 1 year normalizes the miRNA profile of girls with PCOS. Circulating miR-451a may become a biomarker to guide the diagnosis and treatment of PCOS in adolescence.
(Re)Staging the Postcolonial in the World: The Jaipur Literature Festival and the Pakistani Novel
Authors: Sivaram Sushil 
Published: November 2019

Abstract
This article reasons that the Jaipur Literature Festival between 2008 and 2011 attempted to institute via polemics, judgment, and celebration the category of the Pakistani novel in India by importing an alterity industry. By failing to contextualize alterity in a South Asian context, the festival reinforced a national, linguistic, and religious division between India and Pakistan. It produced a category like “Moonlight’s Children” as an “other” to an imagined Indian literature that is confused with a post–Salman Rushdie postcolonial and global anglophone canon. However, this analysis of the discourse produced at the festival by the discussants and the audience shows that a coconstituted South Asian literary history was consistently placed against a regionally competitive model. Importing alterity to produce an Indian or Pakistani literary identity was undermined by an attitude of disavowal toward the literary object and received categories like the global anglophone, postcolonial literature, and world literature. The author argues that this is not postcolonial resistance; rather, it is a trepidation to arrive at a conclusion, because to conclude is also to value, evaluate, and declare the existence of the “other” phantasmagoric literary identity and history.
The Politics of Death and the Question of Palestine
Authors: Sacks Jeffrey 
Published: November 2019

Abstract
This article considers the work of Hannah Arendt and Ghassan Kanafani in relation to the social and juridical logic and form of the settler colony and of the settler-colonial logic and form of the Israeli state and its ideology, Zionism. The argument is framed in relation to two moments: (1) the notion and practice of Bildung—education, training, formation—where the subject of language, in becoming literate, thoughtful, and self-reflective, is to become a being that recognizes itself and others in these and related terms: as legible, autonomous, and self-determining; and (2) the ongoing debates around the politics of death, articulated through the writing of Michel Foucault, Giorgio Agamben, Carl Schmitt, Achille Mbembe, and Arendt. The article argues that, insofar as they presume an understanding of Bildung as a principal category of social thought, these debates reiterate the terms they claim to diagnose or contest. It also argues that, in their affective relation to decolonization, Arendt—and Foucault and Agamben—conjures and advances a social panic in a desire to domesticate the destabilizing force of anticolonial struggle. Finally, the article reads Kanafani’s Rijāl fī al-shams (Men in the Sun) to argue that Kanafani’s novelistic practice discombobulates the terms privileged in the settler colony and in its social and literary logic and form, as it promises a nonredemptive, anomic, and non-state-centric futurity.
Facilitating Inclusive Global Trade: Evidence from a Field Experiment
Authors: Hui Xiang 
Published: November 2019

How can we make global trade inclusive for smaller sellers and firms? I present causal evidence that a major e-commerce platform increases on-site exports from small sellers through integrating an existing administrative and logistic service. The export increase comes exclusively from small sellers and exclusively along the extensive margin—that is, from new sellers or new destinations. Furthermore, the export increase is larger for more distant countries and differentiated products. I provide strong evidence that the distribution of export increase is driven by a reduction in export entry cost. I discuss the importance of reducing export entry cost for facilitating inclusive global trade. This paper was accepted by Chris Forman, information systems.
İslâm’ın İlk Dönemlerinde Piyasa İstikrarını Temin İçin Alınan Tedbirler
Authors: LİV Cemil 
Published: November 2019

İslâm ekonomi
sisteminde akidlerin kuruluşunda irade hürriyeti benimsenmiş, maslahat ve mefsedet dengesi toplumsal alanda
da bireysel alanda da gözetilerek, bireyle toplum arasında adalet merkezli bir
denge kurulmuştur. Özel mülkiyetin elde edilmesi ve kullanılmasında getirilen şartlar ve sınırlar
ile toplumsal refahın sağlanması ve kamu zararının engellenmesi hedeflenmiştir.
Bu bağlamda İslâm ekonomi sisteminde hem şahısların hukukunu korumak hem de toplumsal
menfaati gözetmek amacıyla suni fiyat artışlarını engelleyici tedbirler
alınmıştır. Bu sayede suni fiyat artışlarının önüne geçilerek piyasalarda güven
oluşturulmuş, ekonomik istikrarın devamı
sağlanmıştır. Bu çalışmada İslâm iktisâdında piyasalarda yapılacak manipülatif
işlemlere karşı alınan tedbirlerden, alışveriş yapanlar arasında fiyat
artırımına yönelik müşteri kızıştırmak, ihtiyaç mallarının fiyatlarının artması
için bekletilmesi anlamına gelen ihtikâr, pazara mal getiren tüccarların
mallarının piyasaya arz edilmeden satın alınarak pazar fiyatlarının
yükseltilmesi ve üretici konumunda olan köylünün pazarda doğrudan satışını
engelleyerek ürünlerinin simsarlarca alınıp satılmasının yasaklanması konularının
tahliline yer verilerek, günümüz koşulları açısından önemi vurgulanmıştır.
İslâm ekonomi sisteminin getirdiği bu tedbirlerin günümüzde spekülatörler
tarafından piyasalarda oluşturulan suni pahalılıkla mücadelede rehber olacağı
aşikardır. Özellikle üreticiden tüketiciye kadar malın vasfında, miktarında
veya kalitesinde zorunlu katkısı olmayan aracıların yol açtığı maliyetler,
stokçuluğun her geçen gün artış göstermesi ve tekelleşmenin yol açtığı
spekülatif girişimler karşısında İslâm ekonomi sisteminin çözümleri önem arz
etmektedir. Netice itibariyle, toplumsal refah ve piyasa istikrarı için devlet
denetiminin ve gerektiğinde fiyatları piyasa emsal değerlerinde tutmak için
müdahalesinin kaçınılmaz olacağı görülmektedir.
The Blakean Imagination and the Land in Jez Butterworth’s Jerusalem
Authors: White Simon 
Published: November 2019

Abstract
This essay argues that Jez Butterworth’s Jerusalem challenges what Mark Shucksmith terms the “visioning of rural areas by hegemonic middle-class culture” (163), which still dominates the way many British people see the countryside and is rooted in nostalgia for a neat and pretty rural idyll, cleansed of untidy (bio)diversity. The second major line of argument is that the shadow of William Blake hangs heavily over the play, and that Rooster both embodies and employs the Blakean imagination in ways that challenge dominant “hegemonic” ideas about the rural. The untidy and disruptive Rooster, and the wood that bears his name, represent a very different kind of mindscape and a very different kind of (living) landscape. Simply by his presence in the wood he symbolizes an alternative way of being in the land. It is true that Rooster’s is an imperfect echo of the mythopoetic Blakean world-view, but it is nevertheless unmistakeably Blakean, so the prologue to Jerusalem, part of the preface to Blake’s Milton: A Poem in Two Books (1808), is central to a proper understanding of the play. Rooster’s verbal combativeness and mythopoetic visions penetrate the hypocrisy behind the veneer of respectability in Flintock, and the justifications for prevailing human relationships with the land.