bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recovering Together
Authors: McGlothen-Bell Kelly , Recto Pamela , McGrath Jacqueline M. , Brownell Elizabeth , Cleveland Lisa M. 
Published: December 2020

Background:
Over the past 2 decades, the prevalence of neonatal abstinence syndrome (NAS) has increased almost 5-fold. Skin-to-skin care (SSC), a method of parent–infant holding, is a recommended nonpharmacologic intervention for managing NAS symptoms. SSC has the potential to reduce withdrawal symptoms while positively influencing parent–infant attachment. Yet, little is known about the SSC experiences of mothers of infants with NAS.

Purpose:
The purpose of this study was to explore the SSC experiences of mothers of infants with NAS, including perceived barriers to SSC in the hospital and following discharge home.

Methods:
A qualitative descriptive design was used to obtain new knowledge regarding the experience of SSC of mothers of infants with NAS. Purposive sampling was used to recruit participants eligible for the study. We conducted semistructured individual interviews with postpartum mothers of infants with NAS. Data were analyzed using thematic analysis.

Findings/Results:
Thirteen mothers participated in the study. Four themes emerged from the data analysis: “a little nerve racking”; “she needed me, and I needed her”; dealing with the “hard times”; and “a piece of my puzzle is missing.” SSC was described as a conduit for healing and bonding; in addition, several barriers to SSC were reported.

Implications for Practice and Research:
These findings highlight the inherent benefits of SSC for infants with NAS and demonstrate the unique challenges of these mother–infant dyads. Critical changes in hospital practices are needed to create an environment supportive of SSC for this patient population. In addition, research regarding implementation of interventions to increase SSC usage in this population is warranted.
BRAIN HEALTH ASSESSMENT IN MACULAR DEGENERATION PATIENTS UNDERGOING INTRAVITREAL ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR INJECTIONS (THE BHAM STUDY)
Authors: Ray Subhransu K. , Manz Sarah N. 
Published: December 2020

Purpose:
After intravitreal injection, anti–vascular endothelial growth factor (VEGF) agents are found in the systemic circulation and can suppress systemic VEGF levels. Neuronal health and cognitive function in the central nervous system have been associated with normal physiological levels of VEGF expression. We wished to determine whether there was an association between cumulative anti-VEGF exposure and cognitive function.

Methods:
One hundred and seventy-five patients aged 65 to 85 with vision of at least 20/50 or better in one eye and a diagnosis of age-related macular degeneration took an iPad-based brain health assessment to determine their risk of mild cognitive impairment. The result for each patient was compared with the total number of anti-VEGF injections per individual patient. Patients were then stratified into groups with 0 injections (control), 1 to 9 injections, 10 to 20 injections, or greater than 20 injections.

Results:
The group of patients with more than 20 injections had a higher likelihood of mild cognitive impairment compared with the control group, with statistically significant worse mean Z-scores (P = 0.04).

Conclusion:
Our study is the first to associate worsening cognitive health with higher cumulative anti-VEGF injections. This study was not designed to show a causal link, but does suggest that additional investigation is warranted.
Therapy Dog Effects on Nursing Student Stress
Authors: Hall Deborah , Duke Gloria 
Published: December 2020

Background
Nursing students experience stress levels that may interfere with success in rigorous nursing programs. While evidence indicates therapy dogs can decrease stress, no intervention standards exist, and outcomes are usually measured with questionnaires.

Purpose
The purpose of this research was to enhance empirical evidence supporting a campus therapy dog by explaining the therapy dog's effect on nursing student stress.

Methods
The research used an embedded mixed-methods design. Introductory-level students interacted with a therapy dog on designated days. They measured stress using a smartphone application and Cohen's Perceived Stress Scale. Focus group discussion and program graduate surveys provided qualitative data explaining quantitative results.

Results
Results supported use of a campus therapy dog to decrease nursing student stress.

Conclusions
The therapy dog's regular presence on campus may have improved student outcomes by decreasing stress and improving focus.
The integration between and common prosperity of government and market: China's experience of economic development
Authors: Hu Leming 
Published: December 2020

PurposeThe relationship between government and market is the key to the economic development performance of market economy countries. Due to the limits such as the state/market dichotomy, the focus on static allocation efficiency and the ignorance of the diversity of the market economy and the relationship between government and market, economic liberalism and state interventionism can hardly position and explain the role and evolution of government and market in the real world accurately.Design/methodology/approachChina’s economic transition has always adhered to the reform direction of the socialist market economy and the development goal of a modern socialist country as well as the symbiosis and positive and progressive evolution of government and market, blazing a “third way” in handling the relationship between government and market.FindingsThe “China’s experience” shows that the key for emerging market economies to achieve good economic development performance lies in whether they can build a new relationship of the mutual integration between and common prosperity of government and market regarding target selection, production organisation, technological innovation, institutional change and regulatory adjustment.Originality/valueThe second part of this paper analyses the inherent defects of economic liberalism and state interventionism as well as the reasons why they can hardly be adopted as the theoretical guidance for emerging market economies to handle the relationship between government and market. The third part analyses how China has transcended the inherent thinking of liberalism and interventionism and shaped the new relationship between government and market through goal-oriented, active and progressive, two-way interactive exploration and practice to ensure the success of China's economic transition.
A randomised controlled trial of motivational interview for relapse prevention after release from smoke-free prisons in Australia
Authors: Jin Xingzhong , Kinner Stuart Alistair , Hopkins Robyn , Stockings Emily , Courtney Ryan James , Shakeshaft Anthony , Petrie Dennis , Dobbins Timothy , Puljevic Cheneal , Chang Shuai , Dolan Kate 
Published: December 2020

Purpose
This paper aims to determine whether a single session of a motivational interview (MI) reduces smoking relapse amongst people released from smoke-free prisons.

Design/methodology/approach
This study sought to recruit 824 ex-smokers from 2 smoke-free prisons in the Northern Territory, Australia. Participants were randomised to receive either one session (45–60 min) face-to-face MI intervention 4–6 weeks prior to release or usual care (UC) without smoking advice. The primary outcome was continuous smoking abstinence verified by exhaled carbon monoxide test (<5 ppm) at three months post-release. Secondary outcomes included seven-day point-prevalence, time to the first cigarette and the daily number of cigarettes smoked after release.

Findings
From April 2017 to March 2018, a total of 557 participants were randomised to receive the MI (n = 266) or UC (n = 291), with 75% and 77% being followed up, respectively. There was no significant between-group difference in continuous abstinence (MI 8.6% vs UC 7.4%, risk ratio = 1.16, 95%CI 0.67∼2.03). Of all participants, 66.9% relapsed on the day of release and 90.2% relapsed within three months. On average, participants in the MI group smoked one less cigarette daily than those in the UC within the three months after release (p < 0.01).

Research limitations/implications
A single-session of MI is insufficient to reduce relapse after release from a smoke-free prison. However, prison release remains an appealing time window to build on the public health benefit of smoke-free prisons. Further research is needed to develop both pre- and post-release interventions that provide continuity of care for relapse prevention.

Originality/value
This study is the first Australian randomised controlled trial to evaluate a pre-release MI intervention on smoking relapse prevention amongst people released from smoke-free prisons.
A network-based four-phase routing approach of multisource design change propagation on complex products
Authors: Zhang Na , Li Mengze , Ren Haibing , Li Yupeng 
Published: December 2020

Purpose
The development of complex products and systems is a continuously iterative process from customer requirements to a mature design. Design changes derived from multisources occur frequently during the design process. Furthermore, change propagation will impose impacts on design costs and lead times. In view of this, how to predict and control the propagation of multisource design change to reduce the changes impact is an urgent issue in the development of complex product.

Design/methodology/approach
In this paper, a new four-phase routing approach based on weighted and directed complex networks is proposed for multisource design change propagation. Phase I: as the foundation of this research, a product network model is established to quantify describe the complex product. Phase II: the hub nodes are identified based on the LeaderRank algorithm, which can be regarded as multisource nodes of design changes. Phase III: a calculation method for change propagation intensity is proposed, which improves the systematicness and accuracy of the evaluation results. In this paper, change propagation intensity is defined by four assessment factors: importance degree of parts, execution time of design tasks, coupling strength between parts and propagation likelihood. Phase IV: a routing method of multisource design change propagation and ant colony optimization algorithm are proposed in this paper, which can solve the coupling conflicts among change propagation paths and improve the search efficiency by using the parallel search strategy.

Findings
The proposed method and another method are used to search the optimal propagation path of multisource design change of a motorcycle engine; the results indicate that this method designed in this study has a positive effect on reducing the change impact, market response time and product design costs when design change occurs in the products design process.

Originality/value
The authors find a new method (a network-based four-phase routing approach) to search the optimal propagation path of multisource design change in complex products design.
Effect of age and comorbidity on the ability of quick‐Sequential Organ Failure Assessment score to predict outcome in emergency department patients with suspected infection
Authors: Williams Alex , Griffies Thomas , Damianopoulos Sophie , Fatovich Daniel , Macdonald Stephen 
Published: December 2020

AbstractObjectiveTo determine if a combination of the Charlson Comorbidity Index (CCI) and quick‐Sequential Organ Failure Assessment (qSOFA) score is superior to qSOFA alone for predicting the outcome of ED patients with suspected infection.MethodsA prospective, observational single‐centre study recruited consecutive adult patients who underwent blood culture collection in the ED and were admitted to hospital. The primary outcome was 28‐day in‐hospital mortality, and the secondary outcome a composite of mortality and/or ICU admission ≥72 h duration. The qSOFA and CCI were combined using logistic regression models, and the resulting area under the receiver operating characteristic curve (AUROC) compared to that for qSOFA alone.ResultsOf 551 patients recruited, 18 (3%) died and 27 (5%) attained the composite outcome. The AUROC for qSOFA/CCI versus qSOFA for the primary outcome is 0.79 versus 0.72 (95% confidence interval 0.71–0.88 vs 0.62–0.82, P = 0.055) and 0.80 versus 0.76 (95% confidence interval 0.73–0.86 vs 0.68–0.84, P = 0.048). Deaths among patients not admitted to ICU (12/495) accounted for most of the overall differences in AUROC.ConclusionsThis generates the hypothesis that age and comorbid disease status augment the qSOFA score for predicting adverse outcome among patients with suspected infection in the ED. The results may reflect the predominance of these factors in determining suitability for admission to ICU. Reported limitations of qSOFA to detect the risk of adverse outcome may reflect the influence of unmeasured patient factors.
PD‐L1+ dendritic cells in the tumor microenvironment correlate with good prognosis and CD8+ T cell infiltration in colon cancer
Authors: Miller Timothy J. , Anyaegbu Chidozie C. , Lee‐Pullen Tracey F. , Spalding Lisa J. , Platell Cameron F. , McCoy Melanie J. 
Published: December 2020

AbstractBackgroundThe prognostic value of tumor‐associated dendritic cells (DC) in colon cancer remains poorly understood. This may be in part due to the interchangeable expression of immunostimulatory and immunoinhibitory molecules on DC. Here we investigated the prognostic impact of CD11c+ DC co–expressing the immunoinhibitory molecule PD‐L1 and their spatial relationship with CD8+ T‐cells in patients treated for stage III colon cancer.MethodsTissue microarrays containing representative cores of central tumor, leading edge, and adjacent normal tissue from 221 patients with stage III colon cancer were immunostained for CD8, CD11c, PD‐L1, and cytokeratin using immunofluorescent probes. Cells were quantified using StrataQuest digital image analysis software, with intratumoral and stromal regions analyzed separately. Kaplan‐Meier estimates and Cox regression were used to assess survival.ResultsIntratumoral CD8+ cell density (HR = .52, 95% confidence interval [CI] .33‐.83, P = .007), stromal CD11c+ cell density (HR = .52, 95% CI .33‐.83, P = .006), intratumoral CD11c+PD‐L1+ cell density (HR = .57, 95% CI .35‐.92, P = .021), and stromal CD11c+PD‐L1+ cell density (HR = .48, 95% CI .30‐.77, P = .003) on leading‐edge cores were all significantly associated with good survival. CD8+ cell density was positively correlated with both CD11c+ cell density and CD11c+PD‐L1+ cell density in tumor epithelium and stromal compartments.ConclusionHere we showed that PD‐L1‐expressing DC in the tumor microenvironment are associated with improved survival in stage III colon cancer and likely reflect an immunologically “hot” tumor microenvironment. Further investigation into the expression of immunomodulatory molecules by tumor‐associated DC may help to further elucidate their prognostic value.
Genomic vulnerability to rapid climate warming in a tree species with a long generation time
Authors: Dauphin Benjamin , Rellstab Christian , Schmid Max , Zoller Stefan , Karger Dirk N. , Brodbeck Sabine , Guillaume Frédéric , Gugerli Felix 
Published: December 2020

AbstractThe ongoing increase in global temperature affects biodiversity, especially in mountain regions where climate change is exacerbated. As sessile, long‐lived organisms, trees are especially challenged in terms of adapting to rapid climate change. Here, we show that low rates of allele frequency shifts in Swiss stone pine (Pinus cembra) occurring near the treeline result in high genomic vulnerability to future climate warming, presumably due to the species’ long generation time. Using exome sequencing data from adult and juvenile cohorts in the Swiss Alps, we found an average rate of allele frequency shift of 1.23 × 10−2/generation (i.e. 40 years) at presumably neutral loci, with similar rates for putatively adaptive loci associated with temperature (0.96 × 10−2/generation) and precipitation (0.91 × 10−2/generation). These recent shifts were corroborated by forward‐in‐time simulations at neutral and adaptive loci. Additionally, in juvenile trees at the colonisation front we detected alleles putatively beneficial under a future warmer and drier climate. Notably, the observed past rate of allele frequency shift in temperature‐associated loci was decidedly lower than the estimated average rate of 6.29 × 10−2/generation needed to match a moderate future climate scenario (RCP4.5). Our findings suggest that species with long generation times may have difficulty keeping up with the rapid climate change occurring in high mountain areas and thus are prone to local extinction in their current main elevation range.
B regulatory cells in allergy
Authors: Ma Siyuan , Satitsuksanoa Pattraporn , Jansen Kirstin , Cevhertas Lacin , van de Veen Willem , Akdis Mübeccel 
Published: December 2020

AbstractB cells have classically been recognized for their unique and indispensable role in the production of antibodies. Their potential as immunoregulatory cells with anti‐inflammatory functions has received increasing attention during the last two decades. Herein, we highlight pioneering studies in the field of regulatory B cell (Breg) research. We will review the literature on Bregs with a particular focus on their role in the regulation of allergic inflammation.
Incidence of adverse cardiovascular events in type 2 diabetes mellitus patients after initiation of glucose‐lowering agents: A population‐based community study from the Shizuoka Kokuho database
Authors: Kohsaka Shun , Kumamaru Hiraku , Nishimura Shiori , Shoji Satoshi , Nakatani Eiji , Ichihara Nao , Yamamoto Hiroyuki , Miyachi Yoshiki , Miyata Hiroaki 
Published: December 2020

AbstractAims/IntroductionIncreased incidence of hospitalization for heart failure (HHF) among patients with diabetes is increasingly being reported. We investigated the incidence of adverse cardiovascular events including HHF among patients with type 2 diabetes mellitus, and the potential clinical improvement with sodium–glucose cotransporter 2 inhibitors (SGLT2i) using a contemporary administrative claims database from a large governmental district of Japan.Materials and MethodsWe included initiators of any oral glucose‐lowering drugs between 2013 and 2018. We estimated the 5‐year cumulative incidence of hospitalization for HF, myocardial infarction and stroke, treating death as a competing risk. We evaluated the possible impact of introducing SGLT2i to the potential recipients of the drug, using the inclusion criteria from Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA‐REG OUTCOME) and Dapagliflozin Effect on Cardiovascular Events–Thrombolysis in Myocardial Infarction 58 (DECLARE‐TIMI 58) trials, assuming the same risk reduction as theirs.ResultsAmong 23,340 drug initiators (54.0% men, and 6.4% aged >85 years), the 5‐year cumulative incidence was 5.4% (95% confidence interval 4.9–5.9%) for HHF, 1.9% (95% confidence interval 1.7–2.2%) for myocardial infarction admission and 6.1% (95% confidence interval 5.7–6.6%) for stroke admission. Among 6,192 patients with laboratory test data, 651 (10.5%) and 2,680 (43.3%) patients met the EMPA‐REG‐like and DECLARE‐like criteria, respectively. The 5‐year cumulative incidence among the 2,849 patients meeting either of the criteria was estimated to decrease from 97.1 to 75.6 events through 75% adoption of SGLT2i.ConclusionsThe incidence of HHF was similar to that of stroke. A significant portion of our cohort met the inclusion criteria for major randomized clinical trials for SGLT2i, and estimated reduction in the HHF events was substantial.
Anatomy, ontogeny, and evolution of the archosaurian respiratory system: A case study on Alligator mississippiensis and Struthio camelus
Authors: Schachner Emma R. , Hedrick Brandon P. , Richbourg Heather A. , Hutchinson John R. , Farmer CG 
Published: December 2020

AbstractThe avian lung is highly specialized and is both functionally and morphologically distinct from that of their closest extant relatives, the crocodilians. It is highly partitioned, with a unidirectionally ventilated and immobilized gas‐exchanging lung, and functionally decoupled, compliant, poorly vascularized ventilatory air‐sacs. To understand the evolutionary history of the archosaurian respiratory system, it is essential to determine which anatomical characteristics are shared between birds and crocodilians and the role these shared traits play in their respective respiratory biology. To begin to address this larger question, we examined the anatomy of the lung and bronchial tree of 10 American alligators (Alligator mississippiensis) and 11 ostriches (Struthio camelus) across an ontogenetic series using traditional and micro‐computed tomography (µCT), three‐dimensional (3D) digital models, and morphometry. Intraspecific variation and left to right asymmetry were present in certain aspects of the bronchial tree of both taxa but was particularly evident in the cardiac (medial) region of the lungs of alligators and the caudal aspect of the bronchial tree in both species. The cross‐sectional area of the primary bronchus at the level of the major secondary airways and cross‐sectional area of ostia scaled either isometrically or negatively allometrically in alligators and isometrically or positively allometrically in ostriches with respect to body mass. Of 15 lung metrics, five were significantly different between the alligator and ostrich, suggesting that these aspects of the lung are more interspecifically plastic in archosaurs. One metric, the distances between the carina and each of the major secondary airways, had minimal intraspecific or ontogenetic variation in both alligators and ostriches, and thus may be a conserved trait in both taxa. In contrast to previous descriptions, the 3D digital models and CT scan data demonstrate that the pulmonary diverticula pneumatize the axial skeleton of the ostrich directly from the gas‐exchanging pulmonary tissues instead of the air sacs. Global and specific comparisons between the bronchial topography of the alligator and ostrich reveal multiple possible homologies, suggesting that certain structural aspects of the bronchial tree are likely conserved across Archosauria, and may have been present in the ancestral archosaurian lung.