bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of regional characteristics of land precipitation climatology projected by an MRI-AGCM multi-cumulus scheme and multi-SST ensemble with CMIP5 multi-model ensemble projections
Authors: Ito Rui , Nakaegawa Tosiyuki , Takayabu Izuru 
Published: December 2020

AbstractEnsembles of climate change projections created by general circulation models (GCMs) with high resolution are increasingly needed to develop adaptation strategies for regional climate change. The Meteorological Research Institute atmospheric GCM version 3.2 (MRI-AGCM3.2), which is listed in the Coupled Model Intercomparison Project phase 5 (CMIP5), has been typically run with resolutions of 60 km and 20 km. Ensembles of MRI-AGCM3.2 consist of members with multiple cumulus convection schemes and different patterns of future sea surface temperature, and are utilized together with their downscaled data; however, the limited size of the high-resolution ensemble may lead to undesirable biases and uncertainty in future climate projections that will limit its appropriateness and effectiveness for studies on climate change and impact assessments. In this study, to develop a comprehensive understanding of the regional precipitation simulated with MRI-AGCM3.2, we investigate how well MRI-AGCM3.2 simulates the present-day regional precipitation around the globe and compare the uncertainty in future precipitation changes and the change projection itself between MRI-AGCM3.2 and the CMIP5 multiple atmosphere–ocean coupled GCM (AOGCM) ensemble. MRI-AGCM3.2 reduces the bias of the regional mean precipitation obtained with the high-performing CMIP5 models, with a reduction of approximately 20% in the bias over the Tibetan Plateau through East Asia and Australia. When 26 global land regions are considered, MRI-AGCM3.2 simulates the spatial pattern and the regional mean realistically in more regions than the individual CMIP5 models. As for the future projections, in 20 of the 26 regions, the sign of annual precipitation change is identical between the 50th percentiles of the MRI-AGCM3.2 ensemble and the CMIP5 multi-model ensemble. In the other six regions around the tropical South Pacific, the differences in modeling with and without atmosphere–ocean coupling may affect the projections. The uncertainty in future changes in annual precipitation from MRI-AGCM3.2 partially overlaps the maximum–minimum uncertainty range from the full ensemble of the CMIP5 models in all regions. Moreover, on average over individual regions, the projections from MRI-AGCM3.2 spread over roughly 0.8 of the uncertainty range from the high-performing CMIP5 models compared to 0.4 of the range of the full ensemble.
Androgen deprivation in prostate cancer: benefits of home-based resistance training
Authors: Lam Teresa , Cheema Birinder , Hayden Amy , Lord Stephen R. , Gurney Howard , Gounden Shivanjini , Reddy Navneeta , Shahidipour Haleh , Read Scott , Stone Glenn , McLean Mark , Birzniece Vita 
Published: December 2020

AbstractIntroductionAndrogen deprivation therapy (ADT) has detrimental effects on body composition, metabolic health, physical functioning, bone mineral density (BMD) and health-related quality of life (HRQOL) in men with prostate cancer. We investigated whether a 12-month home-based progressive resistance training (PRT) programme, instituted at the start of ADT, could prevent these adverse effects.MethodsTwenty-five patients scheduled to receive at least 12 months of ADT were randomly assigned to either usual care (UC) (n = 12) or PRT (n = 13) starting immediately after their first ADT injection. Body composition, body cell mass (BCM; a functional component of lean body mass), BMD, physical function, insulin sensitivity and HRQOL were measured at 6 weeks and 6 and 12 months. Data were analysed by a linear mixed model.ResultsADT had a negative impact on body composition, BMD, physical function, glucose metabolism and HRQOL. At 12 months, the PRT group had greater reductions in BCM by − 1.9 ± 0.8 % (p = 0.02) and higher gains in fat mass by 3.1 ± 1.0 % (p = 0.002), compared to the UC group. HRQOL domains were maintained or improved in the PRT versus UC group at 6 weeks (general health,p = 0.04), 6 months (vitality,p = 0.02; social functioning,p = 0.03) and 12 months (mental health,p = 0.01; vitality,p = 0.02). A significant increase in the Matsuda Index in the PRT versus UC group was noted at 6 weeks (p = 0.009) but this difference was not maintained at subsequent timepoints. Between-group differences favouring the PRT group were also noted for physical activity levels (step count) (p = 0.02). No differences in measures of BMD or physical function were detected at any time point.ConclusionA home-based PRT programme instituted at the start of ADT may counteract detrimental changes in body composition, improve physical activity and mental health over 12 months.Trial registrationAustralian and New Zealand Clinical Trials Registry, ACTRN12616001311448
In vitro antidiabetic potentials, antioxidant activities and phytochemical profile of african black pepper (Piper guineense)
Authors: Sulaimon L. A. , Anise E. O. , Obuotor E. M. , Samuel T. A. , Moshood A. I. , Olajide M. , Fatoke T. 
Published: December 2020

AbstractBackgroundDiabetes mellitus is a metabolic disorder of glucose metabolism and management of blood glucose level is the hallmark in the treatment of this disease. The present study investigated chemical composition, in vitro antioxidant and antidiabetic activity of different fractions of 80% methanolPiper guineenseleaves extract.Materials and methodsThe crude methanolic extract ofP. guineensewas obtained following 80% methanol cold extraction and was successively partitioned with dichloromethane (DCM), ethyl acetate (EtOAc), n-butanol (nBuOH) and aqueous solvents to give four fractions. The chemical composition of the fractions fromP. guineensewas determined using gas chromatography coupled with mass spectrometry (GC-MS) and their potentials as antioxidant and anti-diabetes were evaluated.ResultsThe percentage yields were 3.16, 2.22, 0.68 and 0.66% (w/w) in n-butanol, DCM, aqueous and ethyl acetate fractions ofP. guineensemethanolic extract, respectively. The GC-MS analyses identified a total of 71 and 34 phytochemicals in n-butanol and ethyl acetate fractions respectively. Tributyl acetylcitrate (10.95%) and phytol (9.11%) were the major components in the n-butanol fraction while ethyl piperonyl cyanoacetate (27.35%) and phytol (15.17%) were the major constituents in the ethyl acetate fraction. Ethyl acetate fraction had the highest ferric reducing antioxidant power with a value of 53.96 ± 0.40 mgAAE/g while n-butanol fraction possessed highest total antioxidant power (9.98 ± 0.15) followed by aqueous fraction (9.72 ± 0.02). The ethyl acetate and n-butanol fractions with IC50value of 0.24 ± 0.07 and 0.83 ± 0.15 μg/mL respectively elicited significant inhibitory activities against α-glucosidase while only n-butanol fraction (IC50 = 0.33 ± 0.09 μg/ml) exhibited appreciable inhibition against α-amylase activity. However, none of the four fractions showed significant inhibitory activity towards dipeptidyl-peptidase-IV.Conclusionn-butanol and ethyl acetate fractions of 80% methanolP. guineenseleaves extract can be a potential source of bioactive compounds of pharmacological importance in the management of diabetes.
Prevalence and determinants of post--abortion family planning utilization in a tertiary Hospital of Northwest Ethiopia: a cross sectional study
Authors: Abate Enyew , Smith Yolanda R. , Kindie Walelign , Girma Addisu , Girma Yonas 
Published: December 2020

Abstract
Background
Provision of post abortion contraception following an abortion is an excellent opportunity to address unmet family planning needs of women. In Ethiopia, post abortion family planning is minimal and underutilized. The objective of this study is to assess determinant factors for utilization of contraception following any abortion process (induced and/or spontaneous) among reproductive age women (15–49 years) in a tertiary hospital of North West Ethiopia.

Methods
A cross-sectional study was conducted on 423 clients who presented for either spontaneous or induced abortion care from September 2016 to August 2017 in Felege Hiwot referral hospital, North West Ethiopia. Respondents were identified using a consecutive sampling method. Data was collected in clinic using an interviewer administered pre-tested questionnaire administered after services were completed. Factors associated with use of post-abortion family planning were explored using multivariable logistic regression analysis.

Results
64.8% of clients who presented for abortion care received family planning services before discharge from the hospital. Family planning counseling during service provision [AOR: 25.47, 95% CI: (9.11, 71.58)], having previous information about family planning [AOR: 2.16, 95% CI: (1.09, 4.23)], gestational age of index pregnancy less than 3 months [AOR: 1.78, 95% CI:(1.13, 3.05)], being a housewife [AOR: 0.32, 95% CI: (0.16, 0.65)] and monthly income > 5000 ETB [AOR: 0.38, 95% CI:(0.16,0.98)] are significantly associated with post abortion family planning utilization.

Conclusions
The proportion of post abortion family planning utilization is good but could be improved. Education before and especially at the time of abortion services strongly influenced the usage of family planning services. The government and regional health bureau at large as well as health care providers at each health system level have an opportunity to provide information and counsel women on family planning methods to increase utilization of post abortion contraception.
Present status of renal replacement therapy in Asian countries as of 2017: Vietnam, Myanmar, and Cambodia
Authors: Hyodo Toru , Fukagawa Masafumi , Hirawa Nobuhito , Isaka Yoshitaka , Nakamoto Hidetomo , Van Bui Pham , Thwin Khin Thida , Hy Chanseila 
Published: December 2020

AbstractSince 2015, the Committee of International Communication on Academic Research of the Japanese Society for Dialysis Therapy has held its Asian symposium during the society’s Annual Congress to discuss the present status of and demand for dialysis therapy in Asian countries. The aim of the symposium is to identify needs and find ways to contribute in the area of dialysis therapy in these countries. Three manuscripts are presented here by participants at the 2017 Asian symposium from Vietnam, Myanmar, and Cambodia.With economic development, hemodialysis (HD) therapy is now available worldwide. However, the cost of HD is very high compared with the average income in these three countries and, as of 2017, Cambodia and Myanmar have not yet established national health insurance systems. In Cambodia, patients must bear 100% of the cost for dialysis. In Myanmar, the government covers the cost of HD (20 USD, 40% of total cost) in public HD centers, but this service is still insufficient to meet current demand, with long waiting lists of up to 6 months at government HD centers. In contrast, in Vietnam, dialysis is almost completely covered by national health insurance. Dialyzers tend to be reused in all three countries. Continuous ambulatory peritoneal dialysis is available in Vietnam and Myanmar but not in Cambodia. Viable health insurance systems should be established as soon as possible in Cambodia and Myanmar, although this will ultimately depend on the countries’ level of economic development.
Knowledge, attitude and practices about rabies management among human and animal health professionals in Mbale District, Uganda
Authors: Monje Fred , Erume Joseph , Mwiine Frank N. , Kazoora Herbert , Okech Samuel George 
Published: December 2020

AbstractObjectiveTo assess the knowledge, attitude and practices (KAP) of animal and human health professionals towards rabies management and also to establish the level of relationship between KAP.MethodsA cross-sectional study was conducted between December 2012 and March 2013 among 147 randomly selected animal and human health professionals in Mbale District. Of these, only 16 were animal health professionals. Quantitative data was obtained using a semi-structured questionnaire while qualitative data was obtained from 4 Focus Group Discussions (FGDs) and 2 Key Informant (KI) interviews. Quantitative data was entered into EpiInfo version 3.5.1 and proportions computed while qualitative data was summarised into themes and sub-themes resulting from content analysis of interview scripts.FindingsOf all the respondents, only 44% (65/147) had sufficient knowledge about rabies while 25% (37/147) had positive attitude towards rabies management. A half of the respondents (50%, 73/147) had limited good practices. Respondents knowledgeable about rabies were more likely to have positive attitude towards rabies management (OR = 3.65; 95% CI: 1.60–8.3) while respondents with positive attitudes, were more likely to have good practices towards rabies management (OR: 2.22; 95% CI: 1.01–4.86).ConclusionRespondents had low knowledge, negative attitude and limited good practices of rabies management. Regular refresher trainings about rabies to broaden staff knowledge and improve their attitudes and hence practices of rabies management should be conducted by the District leaders. Harnessing multi-sectoral and multi-disciplinary collaborative efforts (“One Health” approach) for rabies control should be instituted to reduce the incidence of the disease in the District.
Magnetic and gravity investigation of kimberlites in north-central Botswana
Authors: Matende Kitso , Mickus Kevin 
Published: December 2020

The Orapa kimberlite field of Botswana is one of the world’s major diamond producing regions. Within this field, there are several small kimberlite pipes that have not been completely explored in terms of their lateral extent, depth, and diamond potential. Two such pipes, BK54 and BK55, were found during a ground gravity and magnetic survey, and subsequent drilling confirmed the presence of kimberlite material. To determine the physical properties of these pipes, their lateral extent, depth, and thickness were estimated using a gravity and magnetic analysis and 2.5D and 3D modeling. Tilt derivatives of the magnetic data indicated that BK54 has a northwest-trending elliptical shape and BK55 has a roughly circular shape. Residual gravity anomaly maps indicate that BK54 does not have a density anomaly whereas BK55 is associated with a gravity maximum. The 3D gravity and magnetic inversion modeling constrained by magnetic susceptibility measurements indicates that BK54 is smaller in volume than BK55 and that neither pipe is thicker than 125 m. The difference in shape and the lack of a gravity anomaly over BK54 implies a different formation mechanism for each kimberlite pipe. Although several mechanisms are suggested, BK54 may have formed by a more explosive eruption producing more tuffistic material in the crater and diatreme facies. The gravity and magnetic analysis also found that the kimberlite pipes, while small, are larger in extent than was determined by drilling and warrant additional drilling to determine their economic potential.
Nanoarchitectonics for Coordination Asymmetry and Related Chemistry
Authors: Ariga Katsuhiko , Shionoya Mitsuhiko 
Published: December 2020

AbstractNanoarchitectonics is a concept envisioned to produce functional materials from nanoscale units through fusion of nanotechnology with other scientific disciplines. For component selection, coordination complexes with metallic elements have a wider variety of element selection because metallic elements cover ca. 80% of the periodic table of the elements. Application of nanoarchitectonics approaches to coordination chemistry leads to huge expansion of this concept to a much wider range of elements. Especially, coordination asymmetry strategy architects asymmetrical and/or chiral structures and/or electronic states through formation of metal coordination complexes, leading to functional material systems in certain anisotropy and selectivity. This review article presents expansion of the nanoarchitectonics concept to coordination asymmetry through collecting recent examples in the field of coordination asymmetry. Introduced examples are classified into several categories from various viewpoints: (i) basic molecular and material designs; (ii) specific features depending on interfacial media, space and contact with bio-functions; (iii) functions; (iv) supporting techniques such as analyses and theory.
Prenatal Exercise and Cardiovascular Health (PEACH) Study: Impact on Muscle Sympathetic Nerve (Re)Activity
Authors: SKOW RACHEL J. , FRASER GRAHAM M. , STEINBACK CRAIG D. , DAVENPORT MARGIE H. 
Published: December 2020

ABSTRACT

Purpose
Women who develop gestational hypertension have evidence of elevated muscle sympathetic nerve activity (MSNA) in early pregnancy, which continues to rise after diagnosis. Exercise has been shown to play a preventative role in the development of gestational hypertension and has been shown to reduce resting and reflex MSNA in nonpregnant populations. We sought to investigate whether aerobic exercise affected the sympathetic regulation of blood pressure between the second and third trimesters of pregnancy.

Methods
We conducted a randomized controlled trial of structured aerobic exercise (n = 31) compared with no intervention (control, n = 28) beginning at 16–20 wk and continuing until 34–36 wk of gestation (NCT02948439). Women in the exercise group were prescribed aerobic activity at 50%–70% of their heart rate reserve, on 3–4 d·wk−1 for 25–40 min with a 5-min warm-up and 5-min cool-down (i.e., up to 160 min total activity per week). At preintervention and postintervention assessments, data from ~10 min of quiet rest and a 3-min cold pressor test were analyzed to determine sympathetic nervous system activity and reactivity.

Results
MSNA was obtained in 51% of assessments. Resting MSNA burst frequency and burst incidence increased across gestation (main effect of gestational age, P = 0.002). Neurovascular transduction was blunted in the control group (P = 0.024) but not in exercisers (P = 0.873) at the postintervention time point. Lastly, MSNA reactivity during the cold pressor test was not affected by gestational age or exercise (P = 0.790, interaction).

Conclusions
These data show that exercise attenuates both the rise in MSNA and the blunting of neurovascular transduction. This may partially explain the lower risk of developing gestational hypertension in women who are active during their pregnancies.
Blood Glucose Responses during Cardiopulmonary Incremental Exercise Testing in Type 1 Diabetes: A Pooled Analysis
Authors: MCCARTHY OLIVIA , PITT JASON , WELLMAN BEN , ECKSTEIN MAX L. , MOSER OTHMAR , BAIN STEPHEN C. , BRACKEN RICHARD M. 
Published: December 2020

ABSTRACT

Purpose
This study aimed to determine the glycemic responses to cardiopulmonary exercise testing (CPET) in individuals with type 1 diabetes (T1D) and to explore the influence of starting blood glucose (BG) concentrations on subsequent CPET outcomes.

Methods
This study was a retrospective, secondary analysis of pooled data from three randomized crossover trials using identical CPET protocols. During cycling, cardiopulmonary variables were measured continuously, with BG and lactate values obtained minutely via capillary earlobe sampling. Anaerobic threshold was determined using ventilatory parameters. Participants were split into (i) euglycemic ([Eu] >3.9 to ≤10.0 mmol·L−1, n = 26) and (ii) hyperglycemic ([Hyper] >10.0 mmol·L−1, n = 10) groups based on preexercise BG concentrations. Data were assessed via general linear modeling techniques and regression analyses. P values of ≤0.05 were accepted as significant.

Results
Data from 36 individuals with T1D (HbA1c, 7.3% ± 1.1% [56.0 ± 11.5 mmol·mol−1]) were included. BG remained equivalent to preexercise concentrations throughout CPET, with an overall change in BG of −0.32 ± 1.43 mmol·L−1. Hyper had higher HR at peak (+10 ± 2 bpm, P = 0.04) and during recovery (+9 ± 2 bpm, P = 0.038) as well as lower O2 pulse during the cool down period (−1.6 ± 0.04 mL per beat, P = 0.021). BG responses were comparable between glycemic groups. Higher preexercise BG led to greater lactate formation during exercise. HbA1c was inversely related to time to exhaustion (r = −0.388, P = 0.04) as well as peak power output (r = −0.355, P = 0.006) and O2 pulse (r = −0.308, P = 0.015).

Conclusions
This study demonstrated 1) stable BG responses to CPET in patients with T1D; 2) although preexercise hyperglycemia did not influence subsequent glycemic dynamics, it did potentiate alterations in various cardiac and metabolic responses to CPET; and 3) HbA1c was a significant factor in the determination of peak performance outcomes during CPET.
Scalable multicast hybrid broadband-crossbar wavelength selective switch: proposal and analysis
Authors: Khope Akhilesh S. P. , Helkey Roger , Liu Songtao , Khope Sairaj , Alferness Rod C. , Saleh Adel A. M. , Bowers John E. 
Published: December 2020

In this Letter, we present a new hybrid broadband-crossbar switching network that can switch multiple wavelengths on demand and can also multicast. This switch fabric is an improvement over our previous design in both switch footprint and power consumption, as it reduces the number of switching elements by approximately 50%. We compare the switch loss and crosstalk with that of a multiwavelength selective crossbar switch. We also comment on fabrication tolerance of second-order ring resonators based on experimental results of 64 second-order ring resonators, and more than 250 heaters.
New trimester-specific reference intervals for clinical biochemical tests in Taiwanese pregnant women-cohort of TMICS
Authors: Chen Hui-Ming , Kuo Fu-Chen , Chen Chou-Cheng , Wu Chia-Fang , Sun Chien-Wen , Chen Mei-Lien , Hsieh Chia-Jung , Wang Shu-Li , Wu Ming-Tsang 
Published: December 2020

BackgroundBecause there are no published biochemical reference intervals (RI) for pregnant Taiwanese women, we used an established islandwide birth cohort, the Taiwan Maternal and Infant Cohort Study, to establish RIs for important biochemical parameters in women during their 3rd trimester in Taiwan. Additionally, we compared the differences in these biochemical parameters between early third trimester (weeks 28 to 31) and late third trimester (weeks 37 to 40) of pregnant women as well as the differences in them between the third trimester and after delivery.MethodsBetween 2012 and 2015, we recruited a total of 2,136 pregnant women from nine hospitals located in northern (n = 3), central (n = 3), southern (n = 2), and eastern Taiwan (n = 1) to receive regular prenatal health examinations during their third trimester (weeks 28 to 40). After exclusion, samples obtained from 993 eligible pregnant women were analyzed.ResultsThere were increases in both lower and upper normal limits for blood neutrophil, thyroid profile (triiodothyronine (T3) and thyroxine (T4)), testosterone, estradiol, and progesterone and decreases for RBC, hemoglobin (Hb), alanine aminotransferase (ALT) and creatinine (Cr) during their third trimesters. Women in their late third trimester (n = 378) had higher median RBC, Hb, aspartate aminotransferase (AST), Cr, thyroid-stimulating hormone (TSH), testosterone, estradiol, and progesterone and lower median platelet and insulin, compared with those in their early third trimester (n = 490). Twenty-three of the women had both third trimester and post-pregnancy data. After delivery, the women had lower median AST, ALT, insulin, T3, T4, testosterone, estradiol, and progesterone and higher median Cr, free T4, FSH, and luteinizing hormone (LH), compared to their third trimesters.ConclusionsGestation-related changes in important biochemical parameters should be considered when evaluating clinical laboratory values in pregnant women.