bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of whole body cryotherapy in patients with rheumatoid arthritis considering immune parameters
Authors: Sadura-Sieklucka Teresa , Sołtysiuk Beata , Karlicka Anna , Sokołowska Beata , Kontny Ewa , Księżopolska-Orłowska Krystyna 
Published: January 2020

ObjectivesWhole body cryotherapy (WBC) is widely used in inflammatory diseases of the joints, including rheumatoid arthritis (RA), but the mechanism(s) of its action is not fully understood. The aim of the study was to compare the effects of WBC and conventional rehabilitation (CR) on the clinical and immune status of RA patients.Material and methodsRheumatoid arthritis patients were classified into 2 groups according to the rehabilitation method used: the study group (CT, n = 25) and control group (CR, n = 25). To measure disease activity, the disease activity score (DAS28) was used, while to assess the morning stiffness and pain intensity, the visual analogue scale (VAS) was applied. Selected laboratory parameters, such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels, were also determined. The serum concentrations of pro- (interleukin 6 [IL-6], tumor necrosis factor a [TNF-a], macrophage migration inhibitory factor [MIF]) and anti-inflammatory (IL-10) cytokines were measured to assess the patient’s immune status.ResultsAfter rehabilitation disease activity (DAS28), morning stiffness and pain intensity (VAS) decreased in both patient groups and no statistically significant differences were observed between them. However, statistically significant improvement in the CRP serum level was observed in the CT group only. No differences were observed in the serum concentrations of tested cytokines either before and after rehabilitation, or between patient groups.ConclusionsWe report that regardless of the type of therapy, comprehensive rehabilitation improves the patient’s clinical status, but has no effect on the levels of circulating cytokines, such as IL-6, IL-10, TNF-a, and MIF, despite significant reduction of a systemic inflammatory marker (CRP), especially in the CT group.
Imaging methods in primary Sjögren’s syndrome as potential tools of disease diagnostics and monitoring
Authors: Świecka Marta , Maślińska Maria , Paluch Łukasz , Zakrzewski Jakub , Kwiatkowska Brygida 
Published: January 2020

Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease that affects exocrine glands, especially salivary and lacrimal glands, leading to their progressive destruction. With highly differentiated clinical course the approach to the definition of pSS is constantly evolving and the pSS classification criteria have been modified over the past years. In the past sialography and scintigraphy were frequently used in pSS diagnostics. Recently no imaging method has been included in the pSS classification criteria. That raises the question about the benefits of using novel imaging techniques such as ultrasonography, elastography and magnetic resonance imaging to diagnose and monitor pSS patients. The purpose of this review is to evaluate the advantages and limitations of widely used imaging methods in pSS and their possible future development.
Classificação dos serviços ecossistêmicos prestados pelas áreas úmidas na zona estuarina do Rio Piancó-Piranhas-Açu (Nordeste, Brasil)
Authors: Saldanha Denise Santos , Costa Diógenes Félix da Silva 
Published: January 2020

As áreas úmidas são ecossistemas importantes tanto para a sociedade como para a biodiversidade, apresentam-se em zonas de transição entre os ambientes terrestres e aquáticos, responsáveis por oferecer serviços para o bem estar humano e biológico, resultantes do seu capital natural. O presente trabalho teve como objetivo avaliar os serviços ecossistêmicos prestados pelas áreas úmidas no complexo estuarino do Rio Piancó-Piranhas-Açu (RN). Foi realizado o mapeamento e classificação das áreas úmidas, assim como a identificação dos serviços ecossistêmicos prestados na área de estudo. A partir desta perspectiva integrada da dinâmica entre o uso humano e seus reflexos nos processos ecológicos dos ecossistemas analisados (ex. manguezal, lagoas, lagunas, salinas solares, etc.), tem-se um melhor entendimento do desempenho destes processos, os quais propiciam a manutenção ou maior disponibilidade de serviços ecossistêmicos considerados chave para a gestão costeira.
Palavras chaves: Capital Natural, Litoral Semiárido do Brasil, SIG, Classificação CICES.
Territorialidades dos malucos de estrada em espaços públicos de João Pessoa/PB
Authors: Gomes Mirelli Albertha de Oliveira , Maia Doralice Sátyro 
Published: January 2020

Popularmente identificados como hippies, os artesãos nômades, que se autodenominam malucos de estrada, expressam uma cultura que se desenvolve inteiramente na rua, mudam constantemente de uma cidade para outra e estabelecem-se como nômades. Em cada cidade que passam, ocupam os espaços públicos e criam a Pedra de Maluco, local onde desenvolvem o trabalho do artesanato juntamente com a construção do habitat. Este artigo objetiva caracterizar a Pedra de Maluco de João Pessoa/PB, localizada na Orla de Tambaú, como apropriação do espaço público pelos malucos de estrada. Através da abordagem etnográfica e da cartografia da ação, observou-se que a Pedra de Maluco configura-se como um território, ou mais especificamente, um nanoterritório (SOUZA, 2013). Ainda que nada tenha de edificado, está preenchida de códigos, rastros e limites invisíveis, o que implica na modificação dos significados e das expressões do espaço bem como na construção da identidade e dos valores dos malucos de estrada, transformando a Pedra de Maluco também em um Lugar.
Palavras-chaves: Malucos de estrada. Apropriação. Espaço público. Território.
O setor avícola no Brasil e sua distribuição regional
Authors: Tremea Franciele Thais , Cericatto da Silva Ariana 
Published: January 2020

A produção nacional de frango de corte tem se destacado entre os demais setores produtivos nas últimas décadas. O exponencial desempenho do setor possibilitou ao Brasil assumir posição de destaque no ranking mundial, como o maior exportador e terceiro maior produtor de carne de frango. Apesar de todos os estados brasileiros produzirem carne de frango, a produção está concentrada na Região Sul do País, sendo o Paraná o principal produtor e exportador de aves do País. Nesse cenário, o objetivo principal deste trabalho foi analisar a especialização da produção de frango de corte, através do Quociente Locacional (QL) e analisar as exportações por meio do Market-Share (MS). Os principais resultados obtidos apontam que o avanço da tecnologia na produção, melhoramento dos índices de conversão alimentar, genética, entre outros, contribuíram para a evolução do setor, tanto em termos de produção quanto em exportação. Neste sentido a região Sul é a mais desenvolvida e especializada neste segmento. O sistema de contrato de integração facilitou o elo entre produtores rurais e agroindústria, com o fornecimento da matéria-prima e assistência técnica, e o produtor com a mão de obra e estrutura necessária. ABSTRACT The national production of broiler chicken has been outstanding among the other productive sectors in the last decades. The exponential performance of the sector enabled Brazil to take a leading position in the world ranking, as the largest exporter and third largest producer of chicken meat. Although all Brazilian states produce chicken meat, production is concentrated in the Southern Region of the country, with Paraná being the main producer and exporter of poultry in the country. In this scenario, this article had as main objective the analysis of the evolution of the poultry production in Brazil from 1995 to 2015, for that the analysis of the specialization of the production of broiler chicken was made through the Locational Quotient (QL) and the analysis of the productive concentration of the exports was made through Market-Share (MS). The main results obtained indicate that the advances in technology in production, improvement of feed conversion, genetic indexes, among others, contributed to the evolution of the sector, both in terms of production and exports. In this sense, the South region is the most developed and specialized in this segment. The integration contract system facilitated the link between rural producers and agribusiness, with the supply of raw material and technical assistance, and the producer with the necessary manpower and structure. KEYWORDS: Poultry industry. Production Specialization. Export of chicken meat.
Effects of Diabetes Mellitus on Functional Outcomes and Complications After Torsional Ankle Fracture
Authors: Schmidt Tegan , Simske Natasha M. , Audet Megan A. , Benedick Alex , Kim Chang-Yeon , Vallier Heather A. 
Published: January 2020

Introduction:
It is well known that patients with diabetes mellitus experience higher complication rates after torsional ankle fracture; however, the functional consequences remain less clear. The goal of this study was to determine the effects of diabetes on complications, secondary operations, and functional outcomes after torsional ankle fracture.

Methods:
Nine hundred seventy-nine adult patients treated surgically for a torsional ankle injury (Orthopaedic Trauma Association 44B, 44C) over 13 years were retrospectively reviewed. Demographic information, comorbidities, injury characteristics, complications, and secondary procedures were recorded. Patient-reported outcome surveys: Foot Function Index (FFI) and Short Musculoskeletal Function Assessment were obtained after minimum of 12 months. Multivariable analysis was done to account for confounding variables.

Results:
One hundred thirty-one patients (13.4%) had diabetes. Diabetic patients were older (56.4 versus 43.0 years, P < 0.001), with no difference in sex or race. Body mass index was higher among diabetics (36.0 versus 30.4, P < 0.001) as were most medical comorbidities, including stroke, neuropathy, pulmonary disease, and renal disease (all P < 0.03). There were no differences in rates of dislocations or open injuries. Diabetics experienced more complications (26.0% versus 14.6%, P = 0.001), specifically deep infections (6.9% versus 1.3%, P = 0.001), and had more secondary procedures (18.3% versus 9.1%, P = 0.001), including débridement, arthrodesis, and amputation (all P < 0.02). Diabetes was a significant independent predictor of worse FFI activity limitation scores (P = 0.032), but was not predictive of worse outcomes on any other subscore of the FFI or Short Musculoskeletal Function Assessment.

Conclusions:
Diabetes was associated with more complications and secondary operations. However, functional outcomes including pain and dysfunction were not markedly affected by these clinical outcomes, potentially due to diminished sensory function and less baseline physical activity among diabetic patients.

Level of Evidence:
Prognostic level III
Editorial
Authors: Campos da Silva Guilherme Amorim 
Published: January 2020

A edição n. 2 de 2019 da Revista Prisma Jurídico é resultado da produção científica realizada em diversos programas de pós-graduação stricto sensu em direito das universidades Brasileiras e de sua relação com universidades estrangeiras.A Revista Prisma Jurídico promove o debate acadêmico, enquanto fonte de consulta e discussão da pesquisa brasileira em Direito.O excelente nível dos trabalhos publicados garante a sua classificação em B1 abrangendo todas as áreas do conhecimento jurídico.Agradecemos a todos autores desta edição pelo fomento do debate científico e qualidade das pesquisas ora publicadas.Cumpre a principal missão de difundir conhecimento e incentivar a pesquisa crítica, repercutindo no avanço da qualidade do ensino do direito. Prof. Dr. Guilherme Amorim Campos da SilvaProfessor Coordenador do Programa de Mestrado em Direito da UNINOVEEditor
Máquinas Virtuales Cognitivas: Desarrollo del Pensamiento Computacional
Authors: Tejada Garitano Eneko , Romero Andonegui Ainara , López de la Serna Aranzazu , Bilbao Quintana Naiara 
Published: January 2020

Las máquinas virtuales cognitivas desde la perspectiva del pensamiento computacional humano, contribuyen a que los estudiantes aprendan a resolver problemas complejos de forma más sencilla y automática sin que medie la tecnología. En este trabajo se presenta una investigación que tiene por objeto conocer la percepción de los estudiantes sobre la utilidad, facilidad y disfrute de uso de las máquinas virtuales cognitivas. El estudio se desarrolló en el marco de un proyecto de innovación docente de la UPV/EHU llevado a cabo con alumnos de cuarto curso del Grado de Educación Primaria de la Facultad de Educación de Bilbao, que tenía por objeto analizar y crear máquinas virtuales cognitivas para resolver problemas de carácter académico de los estudiantes universitarios. Para ello, se llevó a cabo en un estudio de carácter cuantitativo descriptivo. Del estudio se concluye que los estudiantes valoran de forma positiva la utilización de máquinas virtuales cognitivas para realizar un aprendizaje útil.
Cognitive virtual machines from the perspective of human computational thinking, help students to learn how to solve complex problems more easily and automatically without using technolog. This paper presents a research that aims to know the students' perception of the usefulness, ease and enjoyment of the use of cognitive virtual machines. The study was carried out within the framework of a UPV/EHU Teaching Innovation project with students from the last course of the Primary Education Degree (Faculty of Education in Bilbao), which aimed to analyze and create cognitive virtual machines to solve problems of an academic nature of university students. For this, it was carried out in a descriptive quantitative study. The study concludes that students value positively the use of cognitive virtual machines to perform useful learning.
Development of Thermodynamic Model with Gopal’s Constants for the Inhibition of Gas Hydrates Formation in Gas Pipeline
Authors: O. Oluwatoyin Akinsete , A. Sarah Akintola , O. Goodness Folayan 
Published: January 2020

Hydrate deposition remains a very willful one in the oil and gas industry and costs the industry billions of dollars worldwide for prevention and remediation in pipelines and flowlines. An economic and environmentally friendly solution to the prevention of hydrate formation is prohibitively expensive.
In this study, a thermodynamic model for hydrate inhibition in gas pipelines by applying the Joule Thomson Expansion phenomenon was developed. The model is a function of the specific gravity, initial and final temperatures, and the initial and final pressures. This developed model comes with the Gopal's constants that make the model trainable to fit data from various expansion processes.
The results obtained for sweet gases were compared with that presented by the Gas Processors Suppliers Association (GPSA) and an error of less than 5% (R2 = 0.9629) was observed. The effect on sour gases was also considered. The pseudo-reduced temperature ranges from 1.05<Tr<3.0 and the pseudo-reduced pressure ranges from 0.2<Pr<5.4. But at extreme values of both pressure and temperature, the result of the proposed model deviates significantly from that of GPSA. The robustness of this model and its ease of use makes it applicable for real-time calculations in the transportation and processing of natural gases.
LncRNA ZFPM2‐AS1 promotes lung adenocarcinoma progression by interacting with UPF1 to destabilize ZFPM2
Authors: Han Shuhua , Cao Dandan , Sha Jun , Zhu Xiaoli , Chen Dongqin 
Published: January 2020

Lung adenocarcinoma (LUAD), a histological subclass of non‐small‐cell lung cancer, is globally the leading cause of cancer‐related deaths. Long noncoding RNAs (lncRNAs) are emerging as cancer regulators. Zinc finger protein multitype 2 antisense RNA 1 (ZFPM2‐AS1) is an oncogene in gastric cancer, but its functions have not been investigated in LUAD. We showed that ZFPM2‐AS1 expression is high in LUAD samples based on GEPIA database (http://gepia.cancer-pku.cn/) and validated ZFPM2‐AS1 upregulation in LUAD cell lines. Functionally, ZFPM2‐AS1 facilitated proliferation, invasion, and epithelial‐to‐mesenchymal transition of LUAD cells. Thereafter, we found that ZFPM2 was negatively regulated by ZFPM2‐AS1, and identified the suppressive effect of ZFPM2 regulation by ZFPM2‐AS1 on LUAD progression. Mechanistically, we showed that ZFPM2‐AS1 interacted with up‐frameshift 1 (UPF1) to regulate mRNA decay of ZFPM2. Rescue assays in vitro and in vivo confirmed that ZFPM2‐AS1 regulated LUAD progression and tumor growth through ZFPM2. Taken together, our findings demonstrate a role for the ZFPM2‐AS1–UPF1–ZFPM2 axis in LUAD progression, suggesting ZFPM2‐AS1 as a new potential target for LUAD treatment.
Light Gold: A Colloidal Approach Using Latex Templates
Authors: van 't Hag Leonie , Handschin Stephan , Gschwend Pascal M. , Mezzenga Raffaele 
Published: January 2020

AbstractA new 18 karat light gold, composed of gold single crystals, amyloids, and a polymer latex matrix is developed. It is similar to a glassy plastic, yet lighter than aluminum and of use in watches, jewelry, radiation shielding, catalysis, and electronics. The material is prepared via a hydrogel precursor dried into an aerogel. Annealing of the polystyrene matrix under vacuum gives rise to a homogeneous template. The final apparent density and porosity of the material depend directly on the volumetric concentration of the starting solution used for hydrogel formation. After annealing, a homogeneous microstructure is obtained in which the shining gold single crystal platelets are evenly embedded in a polystyrene matrix. The material has a glass transition temperature of ≈105 °C which allows for annealing and molding above this temperature. A general scaling behavior is found for the Young's modulus of the material with the density. The Young's modulus of the material with a density of 1.7 g cm−3 is ≈50 MPa. The density and stiffness, as well as the color, of the material can be tuned depending on the final application.
Ultrasound‐Triggered Enzymatic Gelation
Authors: Nele Valeria , Schutt Carolyn E. , Wojciechowski Jonathan P. , Kit‐Anan Worrapong , Doutch James J. , Armstrong James P. K. , Stevens Molly M. 
Published: January 2020

AbstractHydrogels are formed using various triggers, including light irradiation, pH adjustment, heating, cooling, or chemical addition. Here, a new method for forming hydrogels is introduced: ultrasound‐triggered enzymatic gelation. Specifically, ultrasound is used as a stimulus to liberate liposomal calcium ions, which then trigger the enzymatic activity of transglutaminase. The activated enzyme catalyzes the formation of fibrinogen hydrogels through covalent intermolecular crosslinking. The catalysis and gelation processes are monitored in real time and both the enzyme kinetics and final hydrogel properties are controlled by varying the initial ultrasound exposure time. This technology is extended to microbubble–liposome conjugates, which exhibit a stronger response to the applied acoustic field and are also used for ultrasound‐triggered enzymatic hydrogelation. To the best of the knowledge, these results are the first instance in which ultrasound is used as a trigger for either enzyme catalysis or enzymatic hydrogelation. This approach is highly versatile and can be readily applied to different ion‐dependent enzymes or gelation systems. Moreover, this work paves the way for the use of ultrasound as a remote trigger for in vivo hydrogelation.
Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition
Authors: Ju Yi , Cortez‐Jugo Christina , Chen Jingqu , Wang Ting‐Yi , Mitchell Andrew J. , Tsantikos Evelyn , Bertleff‐Zieschang Nadja , Lin Yu‐Wei , Song Jiaying , Cheng Yizhe , Mettu Srinivas , Rahim Md. Arifur , Pan Shuaijun , Yun Gyeongwon , Hibbs Margaret L. , Yeo Leslie Y. , Hagemeyer Christoph E. , Caruso Frank 
Published: January 2020

AbstractParticle‐based pulmonary delivery has great potential for delivering inhalable therapeutics for local or systemic applications. The design of particles with enhanced aerodynamic properties can improve lung distribution and deposition, and hence the efficacy of encapsulated inhaled drugs. This study describes the nanoengineering and nebulization of metal–phenolic capsules as pulmonary carriers of small molecule drugs and macromolecular drugs in lung cell lines, a human lung model, and mice. Tuning the aerodynamic diameter by increasing the capsule shell thickness (from ≈100 to 200 nm in increments of ≈50 nm) through repeated film deposition on a sacrificial template allows precise control of capsule deposition in a human lung model, corresponding to a shift from the alveolar region to the bronchi as aerodynamic diameter increases. The capsules are biocompatible and biodegradable, as assessed following intratracheal administration in mice, showing >85% of the capsules in the lung after 20 h, but <4% remaining after 30 days without causing lung inflammation or toxicity. Single‐cell analysis from lung digests using mass cytometry shows association primarily with alveolar macrophages, with >90% of capsules remaining nonassociated with cells. The amenability to nebulization, capacity for loading, tunable aerodynamic properties, high biocompatibility, and biodegradability make these capsules attractive for controlled pulmonary delivery.
Accurate Control Multiple Active Sites of Carbonaceous Anode for High Performance Sodium Storage: Insights into Capacitive Contribution Mechanism
Authors: Lu Yun , Liang Jianing , Hu Yezhou , Liu Yi , Chen Ke , Deng Shaofeng , Wang Deli 
Published: January 2020

AbstractHeteroatom doping is widely recognized as an appealing strategy to break the capacitance limitation of carbonaceous materials toward sodium storage. However, the concrete effects, especially for heteroatomic phase transformation, during the sodium storage reaction remain a confusing topic. Here, a novel hypercrosslinked polymerization approach is demonstrated to fabricate pyrrole/thiophene hypercrosslinked microporous copolymer and further give porous carbonaceous materials with accurately regulated N/S dual doping corresponding to starting feeding ratios. Significantly, the N doping contributes to the conductivity and surface wettability, while the S doping is bridged to build stable active sites, which can be electrochemically converted into mercaptan anions via faraday reaction and further enhancing reversible capacities. Meanwhile, the abundant S doping can also conduce to the expanded interlayer spacing to shorten the ions diffusion distance, thus optimizing the reaction kinetic. As a result, the N0.2S0.8‐micro‐dominant porous carbon delivers the highest reversible capacity of 521 mAh g−1 at 100 mA g−1 and excellent cyclic stability over 2000 cycles at 2000 mA g−1 with a capacity decay of 0.0145 mAh g−1 per cycle. This work is anticipated to provide an in‐depth understanding of capacitance contribution and illuminate the heteroatomic phase transformation during sodium storage reactions for doping carbonaceous anodes.
Eliciting Consumer Willingness to Pay for Home Internet Service: Closing the Digital Divide in the State of Indiana
Authors: Lai John , Widmar Nicole O. , Bir Courtney 
Published: January 2020

AbstractThe economic and societal benefits of broadband have been well documented, including increased access to education, civic engagement, political participation, and public education. However, there continues to be disparity between rural and urban areas regarding internet access/speed. With the second highest Midwestern rural population density, this analysis sought to quantify usage of internet services and estimate Indiana residents’ willingness to pay (WTP) for home internet service. This analysis found the mean WTP for residents is between $0.06/Mbps and $0.10/Mbps per month for broadband. Age has a significant positive relationship with WTP for fiber optic internet; subscriber's employment also plays a significant role.