bluuebunny/crossref_metadata_2025_split huggingface dataset:
SDF-1α Reduces Human Natural Killer Cell Cytotoxicity against Chronic Myelogenous Leukemia K562 Cells
Authors: Mardomi Alireza , Hossein-Nataj Hadi , Jafari Narjes , Mohammadi Nabiallah , Abediankenari Saeid 
Published: December 2019

Stromal cell-derived factor-1 alpha (SDF-1α) has been shown to be up-regulated in a variety of malignancies. So that, its expression is associated with poor prognosis and invasiveness. Natural killer (NK) cells are important effector cells against virus-infected and transformed cells. Especially they play a key role in tumor immune surveillance.
Whereas it was not well understood whether SDF-1α modulates anti-tumor immune response or not, the purpose of the present study was to investigate the effect of SDF-1α on the cytotoxic properties of peripheral blood NK cells.
Human peripheral blood NK cells were freshly isolated using MACSxpess system and cultured in the presence or absence of recombinant human SDF-1α or SDF-1α plus CXCR4 antagonist, AMD3100. CD107a degranulation assay was conducted through the co-culture of NK cells with K562 cells. The percentage of CD107a positive cells was assessed by flowcytometry. Effect of SDF-1α was also examined on the mRNA levels of NKG2A and NKG2D as indicator examples of NK cell inhibitory and activating receptors, respectively. SDF-1α significantly decreased the degranulation activity of NK cells (p=0.04). The mRNA content of NKG2D was down-regulated under the influence of SDF-1α (p=0.03). Moreover, AMD3100 exhibited a trend in recovering the NKG2D mRNA level to its un-treated state (p=0.05).
The present study reveals that SDF-1α has a negative impact on NK cell activity and might is involved in tumor immune-suppression. Thus, it can be concluded that microenvironment manipulations targeting SDF-1α may reinforce current cancer therapies by disturbing one of the immune-suppressive axes in the cancerous milieu.
Mammalian Meat Allergy Accompanied by Venom Allergy: A Review of 12 Cases
Authors: Kutlu Ali , Unal Derya 
Published: December 2019

There has recently been an increase in mammalian meat allergy (MMA) in the Black Sea Region of Turkey. It has been associated with the expansion of tick populations.Tick bites appear to result in sensitization to the carbohydrate allergen galactose-alpha–1, 3-galactose, which is present in many types of mammalian meats.
In this study, we have emphasized that Ixodes ricinus named tick type which is implicated in meat allergy, is found in domestic animals of Black Sea Region of Turkey. A new concept has been recently raized; suggesting that having an alpha-gal allergy is associated with an increased risk of sensitization to multiple venom spesific immunoglobulin (Ig) E. Our aim is to evaluate the clinical characteristics of adult patients with MMA and its relationship with insect sting reactions in Turkey.
Patients referring to the allergy outpatient clinic with possible MMA were interviewed regarding reactions to a stinging insect. Demographic features and detailed histories of the patients were recorded. Skin prick test (SPT) with commercial beef extract and venom allergens, as well as prick to prick tests with raw beef and cooked beef were performed. Serum total IgE and beef meat specific IgE were measured.
Of 50 interviewed patients, 12 patients (4 male [33,3%] and 8 female [66,6%]) had a history of venom hypersensitivity reaction. The mean age was 36.50±13.35 years (range:18–61). History of other allergic diseases was present in 8 (66.6%) patients. Both venom and meat allergy were confirmed with SPT or prick to prick tests in these 12 patients. Among these patients sensitization to honey bee venom was more frequent (83%). MMA and venom allergy are influenced by the same environmental exposures. We believe that there may be shared immunologic factors and similar antigens; making venom allergic patients more susceptible to MMA.
SCHOOL PROBLEMS IN THE EDUCATION AND DEVELOPMENT OF GIFTED CHILDREN: PSYCHOLOGICAL ASPECT
Authors: F. Gali Gulnara , I. Fakhrutdinov Bulat , Z. Shakhnina Irina , N. Zagladina Elena 
Published: December 2019

Purpose of the Study: The urgency of the problem under investigation is due to the fact that the issue of gifted students’ education is one of the most difficult and interesting aspects of contemporary pedagogy. The purpose of the article is to identify the psychological characteristics of the gifted students’ development. In this article, the school difficulties of gifted students are revealed and the causes of internal and external nature are analyzed. The authors pay special attention to the social and emotional consequences, which can be rather destructive if appropriate assistance is not provided by teachers, psychologists, and parents.
Methodology: The leading approach to the study of this problem is a method of theoretical analysis and synthesis of social, political and psycho-pedagogical literature.
Results: The main result of the study is a theoretical analysis of the relationship between learning and the development of gifted children and their psychological characteristics.
Application: The materials of the article can be useful for teachers, students and a wide range of readers interested in the problems of gifted students’ education.
THE CORRELATION BETWEEN PATIENT SATISFACTION AND PEOPLE EQUITY AMONG PARAMEDIC STAFFS IN INPATIENT ROOMS
Authors: Puspitasari Sendhi Tristanti 
Published: December 2019

Background: One of the elements controlling the quality of hospital health services is patient and employee satisfaction. The mean value of patient satisfaction with all parameters of inpatient rooms at the Islamic Hospital in Surabaya from January to August 2016 was 61.3% which is less than the standard of ≥ 90%. Whereas, people equity is a concept of human resource management that signs organizational performance.Aims: This study examined the correlation between patient satisfaction and people equity among paramedic staffs especially in inpatient rooms of the Islamic Hospital in Surabaya.Methods: This study focused on measuring people equity, patient satisfaction, and the correlation between people satisfaction and people equity. The questionnaire used in this study adopted RATER dimensions (Reliability, Assurance, Tangible, Empathy, and Responsiveness).Results: The study found that three inpatient rooms (Muzdalifah, Arofah, and Shofa) did not meet three elements of people equity (Alignment, Capabilities, and Engagement). Patient satisfaction with the inpatient rooms was good, except for the tangible dimension especially room cleanliness which is still relatively low. People equity among the paramedic staff has strong relevance and is directly proportional to patient satisfaction with the inpatient rooms of the Islamic Hospital in Surabaya.Conclusion: Internalizing an organizational culture that considers patient satisfaction and patient equity among paramedic staffs is essential to harmonize the goals, vision, and mission between the hospital and its staffs. This study recommends that there should be a more serious evaluation of the cleanliness of all service units at the Islamic Hospital in Surabaya.Keywords: Patient satisfaction, People equity, Human Resource Management, Service performance.
Pedagogical Affection in Didactics of Mathematics - Amazonas Region from the Phenomenology Perspective
Authors: Zumaeta Arista Segundo , Fuster Guillen Doris , Ocaña Fernández Yolvi 
Published: December 2019

<p>La presente investigación tuvo como propósito analizar las experiencias vividas en la didáctica de la matemática de los docentes de la región Amazonas, cuyo significado emergente fue el afecto pedagógico en la enseñanza entendida como un proceso por el cual dos o más personas realizan una interacción social, una de las pasiones que el ánimo presenta. El estudio fue realizado con los procesos del método fenomenológico hermenéutico, con una muestra por criterio de cinco docentes del área; las técnicas utilizadas son observación de cerca y entrevista conversacional. El instrumento para recoger los testimonios de cada docente y reflexionar fue la anécdota. De ellas emergieron unidades temáticas como la preocupación, la confianza, la humildad, la esperanza, la empatía, entre otras, y como significado general el afecto. De las experiencias vividas por los docentes emerge la afectividad en la enseñanza de la matemática, la que conduce a buenas relaciones personales, brinda esperanza, color y sentido a los aprendizajes, a los actos y a la vida misma del estudiante.</p><div> </div>
Stabilitas Fisik Sediaan Emulgel Ekstrak Etanol Daging Buah Limpasu (Baccaurea lanceolata (Miq.) Müll. Arg.)
Authors: Ratnapuri Prima Happy , Haitami Fajrina , Fitriana Mia 
Published: December 2019

ABSTRAK Ekstrak etanol daging buah limpasu (Baccaurea lanceolata (Miq.). Müll. Arg.) telah teruji memiliki aktivitas tabir surya secara in vitro, sehingga diformulasikan dalam bentuk sediaan emulgel dengan variasi konsentrasi (% b/b) ekstrak etanol daging B.lanceolata FI (4%), FII (5%) dan FIII (6%). Sediaan emulgel yang telah dibuat selanjutnya perlu dilakukan uji stabilitas fisik saat penyimpanan. Penelitian ini bertujuan untuk menentukan stabilitas fisik sediaan emulgel ekstrak etanol daging buah B. lanceolata selama penyimpanan. Uji stabilitas fisik dilakukan selama 28 hari pada suhu tinggi 40°±2°C dan suhu ruang 28°C±2°C dengan evaluasi meliputi uji organoleptis, uji pH, uji daya sebar, uji daya lekat dan uji viskositas pada hari ke-0, 7, 14, 21 dan 28. Analisis secara statistik dilakukan dengan software SPSS 21 pada taraf kepercayaan 95%. Hasil penelitian pada formula I, II, dan III dengan variasi konsentrasi ekstrak menunjukkan bahwa penyimpanan selama 28 hari pada suhu tinggi 40°±2°C dan ruang 28°C±2°C tidak mempengaruhi kestabilan pH, viskositas, daya sebar dan daya lekat gel (p>0,050). Kesimpulan dari penelitian ini menunjukkan bahwa sediaan emulgel ekstrak etanol daging B. lanceolata stabil secara fisik selama 28 hari pada suhu tinggi 40°±2°C dan suhu ruang 28°C±2°C. Kata Kunci: Baccaurea lanceolata, ekstrak etanol, emulgel, stabilitas fisik. ABSTRACT Limpasu (Baccaurea lanceolata (Miq.). Müll. Arg.) fructus ethanol extract has been reported as sunscreen activity by in vitro test, so that it could be formulated in sunscreen product with their concentration variances FI (4%), FII (5%) and FIII (6%) (% b/b). The further this preparation needs to be tested for physical stability during storage. This study aimed to determine the emulgel stability physically of B.lanceolata fructus ethanol extract during storage. Physical stability test was performed at high temperature 40°±2°C and room temperature of 28°±2oC during 28 days with evaluation including organoleptic, pH, dispersive, adhesion power and viscosity test on days 0, 7, 14, 21 and 28. Statistical analysis, SPSS 21 software at 95% confidence level. This study results, formula I, II, and III with their concentration variances showed that storage for 28 days at high temperature 40°±2°C and 28°±2° C didn’t affect the pH, viscosity, dispersive, adhesion power stability (p>0,050). The conclusion of this study showed that the emulgel preparation of B. lanceolata fructus ethanol extract were physically stable for 28 days at high temperature of 40°±2°C and room temperature of 28°C±2°C. Keywords: Baccaurea lanceolata, ethanol extract, emulgel, physical stability
The role of growth factor in the repair of articular cartilage
Authors: Zhang Yu , Chai Zishu , Yu Chengqiang , Wu Youcai , Ou Yufu , Wei Jianxun 
Published: December 2019

Abstract
Background: Natural degeneration or trauma of articular cartilage all can lead to its structural and functional damage. Because of its lack of blood supply and innervation, it has low metabolic activity and difficulty in self-repair after injury. Growth factors provide a new direction for the repair of articular cartilage damage and play an important role. This article will systematically summarize the research progress of traditional growth factors, mainly introduce the newly found growth factors and other synthetic compounds and inorganic particles that can induce stem cells to differentiate into cartilage.Methods: English literatures published in PubMed and SCI databases from August 2000 to August 2019 were searched, Review the relevant literature, The two authors evaluated and screened the quality of the literatures respectively, and senior authors further evaluated them to resolve the disagreement on the inclusion of literatures.Results: Growth factors can significantly promote stem cell proliferation and differentiation. A variety of growth factors can exert synergistically to promote the differentiation of stem cells into cartilage, so as to promote the regeneration of cartilage tissue and repair the damage of articular cartilage. Traditional growth factors that promote articular cartilage repair are bone morphogenetic proteins, cartilage derived morphogenetic protein, transcription growth factor β, fibroblast growth factors and insulin⁃like growth factors. Recent studies have found that kartogenin, platelet-rich plasma, platelet-rich fibrin, force growth factor, etc. can also effectively induce stem cells to differentiate into cartilage and maintain chondrocyte phenotype, synthetic compounds such as dexamethasone and some inorganic particles also promote chondrogenic differentiation.Conclusions: The newly discovered growth factors promote the development of articular cartilage repair, but its mechanism of action is not clear. There are no in vivo experimental studies on dexamethasone and inorganic particles, and its repairing effect and safety are for further study. The synergistic or antagonistic effects between different growth factors, the optimal concentration ratio, and the differences in in vivo and in vitro roles need further study. At present, the research on growth factors mostly stays at the basic stage, and there are few clinical studies, which will be an important direction for further research.
Effects of aquatic physical intervention on fall risk, working memory and hazard-perception as pedestrians in older people
Authors: Nissim Michal , Livny Abigail , Barmatz Caroline , Tsarfaty Galia , Berner Yitshal , Sacher Yaron , Giron Jonathan , Ratzon Navah Z. 
Published: December 2019

Abstract

Background: Normal aging is associated with balance, mobility and working memory decline that increase fall risk and influence activity of daily living functions. Mounting evidence suggests that physical activity is beneficial for decreasing aging effects. The environment in which the physical activity occurs influences the results of the activity. Previous studies have focused on land-based physical activity. Research concerning the aquatic environment is scarce. The purpose of this study was to examine the effects of an aquatic physical intervention program on fall risk, working memory and safety of streets–crossing among community-dwelling older individuals.Methods: Forty-two healthy participants aged 65 or older were divided into one of three intervention groups: aquatic physical intervention (API), on-land physical intervention (OLPI) or non-physical intervention (NPI). The intervention took place from 2018 until 2019 and the protocol included 30-minute sessions twice a week for 12 weeks. Balance, gait and fall risk, working memory abilities and simulated safe streets-crossing were tested. Testing and data collection was conducted at baseline, after six weeks and 12 weeks of intervention. Results: After six and 12 weeks of intervention, the API group achieved higher improvement on fall-risk score as compared to the NPI group, and both OLPI and NPI groups achieved less improvement on balance score compared to the API group. Additionally, after 12 weeks of intervention, both OLPI and NPI groups scored significantly lower than the API group in verbal and visuospatial working memory tests. Finally, a trend of improvement was found on the hazard-perception as pedestrians test after 12 weeks of intervention only among the API group. Conclusions: These findings may affect experts working with the elderly population when making decisions concerning therapeutic prevention interventions for the deficiencies of elderly patients. Such interventions may help reduce falling and cognitive deficits, which can lead to decreased injuries and fatalities of older pedestrians. Older adults practicing aquatic physical activity could contribute to their increased safety. Trial registration Trial registration number: ClinicalTrials.gov Registry NCT03510377. Date of registration: 10/31/2017 https://clinicaltrials.gov/ct2/show/NCT03510377
First isolation of Mycobacterium ulcerans from Swabs and Fine-Needle-Aspiration Specimens in Togo.
Authors: Makagni Tchalare Kondi , Issaka Maman , Ebekalisai Piten , Kodjo Disse , Kadanga Essossimna A. , Sambiani Tchao , Madimili Lowa Pya-Abalo , Eyabavi Eza , Simplice Karou Damintoti , Anoumou Dagnra , Tchadjobo Tchacondo 
Published: December 2019

Abstract
Background Buruli ulcer is a skin disease caused by a mycobacterium called Mycobacterium ulcerans . It is prevalent in more than 33 countries on several continents but West Africa is the most affected. The isolation in culture of the bacteria is difficult because of its slow growth and the facilities required. In Togo, studies have been done on the risk factors for Mycobacterium ulcerans infection and the detection of cases by the Ziehl-Neelsen and PCR technique on clinical and environmental samples, but to date no data of isolates from clinical samples are available. The purpose of this study was to perform an in vitro culture of M. ulcerans from swab and fine needle aspiration samples through the confirmation stages of direct examination and IS2404 -PCR. Method A total of 70 clinical samples from Togo and 10 clinical isolates from Benin are analyzed by the three techniques indicated in the diagnosis, in particular the direct examination of acid-fast bacilli (AFB) using the Ziehl-Neelsen staining, the PCR targeting the IS2404 sequence, and the culture after transport of the samples in a transport medium made of Middlebrook 7H9 medium supplemented with a mixture of PANTA and OADC and decontamination by the modified Petroff method. Results The application of the three techniques of diagnosis for clinical samples yielded 44.28% of positivity rates on direct examination of AFB, 35.71% on culture and 77.14% on qPCR IS2404 with a significantly higher rate for qPCR (0.0001). All samples positive for Ziehl-Neelsen staining and culture were also positive for qPCR. Conclusion : Our results show that the culture, despite it difficulty and the slow growth of the bacteria, can be carried out with recommended tools of the mycobacteria culture and a good method of decontamination of the samples can improve the positivity rates. Its realization will allow the assessment of the in vitro sensitivity to the antibiotics used in the treatment and the discovery of new strains of Mycobacterium ulcerans .
Obesity, lifestyle behaviors and dyslipidemia among Chinese adults aged 45 and older
Authors: Liu Pengtao , You Yinghui , Meng Qinghui , Tian Chunhua , Wang Junjie , Ma Guifeng 
Published: December 2019

Abstract
Background This study investigated the importance of obesity and lifestyle behaviors in affecting dyslipidemia among adults aged 45 and older in China. The strength of our study is in using the decision tree model to clearly rank the importance of those key factors affecting dyslipidemia.Methods Data were taken from the China Health and Retirement Longitudinal Study. A total of 9,038 adults were included in the study. Logistic regression was used to examine the associations between obesity, lifestyle behaviors and dyslipidemia. Decision tree was built to select the best scheme on prevention of dyslipidemia.Results Based on body mass index (BMI), 33.98% of Chinese age ≥ 45 years old were overweight and a further 12.73% were obese. Logistic regression analysis showed that participants who were obese (AOR 6.82, 95% CI 3.67–12.37, P<0.0001), with hypertension stage 2 (1.53, 1.23–1.90, P=0.0001) and lived in main city zone (2.68, 2.22–3.22, P<0.0001) were more likely to have dyslipidemia; Participants who usually took part in vigorous activity (0.66, 0.54–0.80, P<0.0001) or did moderate/light activity more than 2 hours one day (moderate: 0.66, 0.53–0.84, P=0.0005; light: 0.79, 0.65–0.97, P=0.0231) were less likely to have dyslipidemia. Decision tree analysis showed that enhancing physical activity could effectively reduce the rate of dyslipidemia among people with overweight or obesity.Conclusions Overweight and obesity are rapidly growing threats in China. Regular physical activity could positively affect dyslipidemia and produce desirable health status. This will be beneficial evidence for educating those who do not or cannot perform regular and substantial physical activities.
Design and operation of submerged layer in bioretention for enhanced nitrate removal
Authors: Zhang Junyu , Singh Rajendra Prasad , Liu Yunzhe , Fu Dafang 
Published: December 2019

Abstract
Bioretention, initially designed for treating discontinuous runoff pollution, faces considerable challenges in its trade-off between the hydraulic retention time (HRT) and its treatment capacity. In this study, six enhanced submerged media together with four HRTs were designed for bioretention cells to treat the highly nitrogenous river water in Tai lake basin in Yangtze River delta, China. Results revealed that bioretention with activated carbon has the highest removal of nitrate (NO3−-N) (93–96%) compared with surfactant-modified activated carbon (SMAC), surfactant-modified zeolite (SMZ), zeolite, fly ash and ceramsite. Although the SMAC had the best absorption for NO3−-N and could desorb NO3−-N when its concentration was low in the submerged layer, the desorbed surfactant could inhibit the growth of denitrifying bacteria, which leads to low removal efficiency (49–66%). The dynamic balancing of NO3−-N desorption and denitrifying system restrain in the SMAC device was observed and explained. The best activated carbon-gravel proportion in the submerged layer was 1:1 (150 mm). Such design could ensure the stable and efficient NO3−-N removal rate (93–94%) under high inflow concentration (28.9 mg/L) and high hydraulic loading (8.2 cm/h).
Logarithmic transformation and peak-discharge power-law analysis
Authors: Chen Bo , Ma Chunying , Krajewski Witold F. , Wang Pei , Ren Feipeng 
Published: December 2019

AbstractThe peak-discharge and drainage area power-law relation has been widely used in regional flood frequency analysis for more than a century. The coefficients and can be obtained by nonlinear or log-log linear regression. To illustrate the deficiencies of applying log-transformation in peak-discharge power-law analyses, we studied 52 peak-discharge events observed in the Iowa River Basin in the United States from 2002 to 2013. The results show that: (1) the estimated scaling exponents by the two methods are remarkably different; (2) for more than 80% of the cases, the power-law relationships obtained by log-log linear regression produce larger prediction errors of peak discharge in the arithmetic scale than that predicted by nonlinear regression; and (3) logarithmic transformation often fails to stabilize residuals in the arithmetic domain, it assigns higher weight to data points representing smaller peak discharges and drainage areas, and it alters the visual appearance of the scatter in the data. The notable discrepancies in the scaling parameters estimated by the two methods and the undesirable consequences of logarithmic transformation raise caution. When conducting peak-discharge scaling analysis, especially for prediction purposes, applying nonlinear regression on the arithmetic scale to estimate the scaling parameters is a better alternative.