bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the importance of gamification, social interaction and perceived enjoyment among young female online buyers in India
Authors: Raman Prashant 
Published: September 2020

PurposeThe current research has dual motives. Firstly, this study aims to evaluate the effect of gamification on the behavioural intention (BI) of the young female consumers to use online websites for making purchases. Secondly, it examines the role of social interaction and perceived enjoyment (PE) – two antecedents that are considered to have an impact on the female buying behaviour in e-commerce.Design/methodology/approachA model is developed based on the technology acceptance model. The conceptual framework is augmented with additional constructs such as gamification, PE and social interaction. Data from a survey of 898 female respondents from India was collected to assess the proposed framework. The study uses partial least squares structural equation modelling technique to empirically validate the model.FindingsGamification exhibits a favourable influence on BI of young female consumers. Gamification also has a favourable and an indirect influence on BI through social interaction and PE. Although, gamification has a significant influence on perceived usefulness, the latter has no impact on the BI. The BI of using an online shopping website is directly associated with the buying intention. The online retailers need to offer an enjoyable and interactive experience to the female consumers so that the influence of gamification is sustainable.Originality/valueThe current research enlarges the ambit of gamification in the e-commerce segment, an area where empirical research is sparse. It highlights the significance of social interaction and PE as mediators. To the best of the author’s knowledge, gamification’s influence on female online buying behaviour has never been analysed before and hence different segmentation and marketing strategies are required to cater to their unique needs.
Changing the terminology from kidney replacement therapy to kidney support therapy
Authors: Raina Rupesh , Joshi Hirva , Chakraborty Ronith 
Published: September 2020

AbstractKidney replacement therapy (KRT) is a common supportive treatment for renal dysfunction, especially acute kidney injury. However, critically ill or immunosuppressed patients with renal dysfunction often have dysfunction in other organs as well. To improve patient outcomes, clinicians began to initiate kidney replacement therapy in situations where nonrenal conditions may lead to acute kidney injury, such as septic shock, hematopoietic stem cell transplantation, veno‐occlusive renal disease, cardiopulmonary bypass, chemotherapy, tumor lysis syndrome, hyperammonemia, and various others. In this review, we discuss the use of various modes of kidney replacement therapy in treating renal and nonrenal complications to illustrate why kidney support therapy is a more appropriate terminology than kidney replacement therapy.
Pea starch exhibits good expansion characteristics under relatively lower temperatures during extrusion cooking
Authors: Rangira Irene , Gu Bon‐Jae , Ek Pichmony , Ganjyal Girish M. 
Published: September 2020

AbstractExtrusion processing characteristics of pea starch were studied as impacted by various extrusion cooking processing variables, including, moisture content (15%, 17.5%, and 20% w.b.), temperature (120, 135, and 150 °C), and screw speed (150, 200, and 250 rpm), in a co‐rotating twin‐screw extruder. Physicochemical properties such as radial expansion ratio (ER), unit density (UD), water absorption index (WAI), and water solubility index (WSI) were measured. ER of the extrudates ranged between 2.52 and 3.63. These values of ER were significantly high, although relatively lower compared to the highest values reported in the literature for corn and rice extrudates. The UD values for all the extrudates ranged from 0.12 to 0.35 g/cm3, WAI, and WSI values ranged from 10.98 to 12.10 g/g and from 0.12% to 7.73%, respectively. Both screw speed and moisture content had significant impacts on the ER (P < 0.01). The highest ER was observed for the extrusion cooking conditions of the lowest moisture content level (15%), lowest barrel temperature (120 °C), and lowest screw speed (150 rpm). The cross‐sectional microstructure of the extrudates showed that the samples with a high ER had thick and elongated pores. The results of this study indicate that pea starch is a viable ingredient for making puffed extruded products.Practical ApplicationThe food industry can utilize the information generated from this study in the development of extruded expanded food products with pea starch. The specific information related to process conditions can assist the food industry in determining the ideal conditions for extrusion cooking in the production.
An Exploratory Factor Analysis of the Stimulant, Sedative, and Affective Responses to Alcohol
Authors: Grodin Erica N. , Green Re Joyce , Ray Lara A. 
Published: September 2020

BackgroundSubjective response (SR) to acute alcohol reflects individual variance to the sensitivity of alcohol’s pharmacological effects. It has been argued that measures of stimulation and sedation may not fully capture the full‐range SR, with 2 novel domains proposed: high arousal negative and low arousal positive. While substantial progress has been made in the field of SR and alcohol use risk, it remains unknown how these novel domains correspond to traditional SR measures. Therefore, the current study examined the latent structure of traditional and novel SR measures at rising breath alcohol concentrations (BrACs) during alcohol administration.MethodsHeavy drinkers (n = 67; 36M/31F) participated in an intravenous alcohol administration. Questionnaires assessing stimulation, sedation, mood, valence and arousal, and craving were assessed at baseline and at BrACs of 20, 40, and 60 mg%. A series of exploratory factor analyses were conducted to examine the latent factor structure of SR at each time point. Correlations examined the association between the generated factors and measures of problematic alcohol use.ResultsThe analysis generated a 3‐factor solution, consistent across all time points. The factors measured the following effects of SR: (i) stimulation and positive mood, (ii) sedation and aversive effects, and (iii) tension reduction. The tension reduction factor was most commonly associated with problematic alcohol use in this sample.ConclusionThis study extends upon the literature evaluating the biobehavioral effects of alcohol by examining a novel combination of SR to alcohol measures. This study demonstrates that the proposed low arousal positive domain, which loaded onto the tension reduction factor, provides novel information not captured by previous SR measures. Going forward, studies of alcohol’s subjective effects should use this dimensional approach to reduce multiple comparisons across a wide range of scales and to build a literature grounded on the underlying structure of SR as a translational phenotype for AUD.
Systemic Administration of the AMPA Receptor Antagonist, NBQX, Reduces Alcohol Drinking in Male C57BL/6J, But Not Female C57BL/6J or High‐Alcohol‐Preferring, Mice
Authors: Bauer Meredith R. , Garcy Daniel P. , Boehm Stephen L. 
Published: September 2020

Backgroundα‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptors are ionotropic glutamate receptors that have been investigated for their role in modulating alcohol consumption. However, little is known about the role of AMPA receptors in the control of binge‐like or free‐access alcohol drinking in C57BL/6J or in selectively bred high‐alcohol‐preferring (HAP) mice. The purpose of this experiment was to assess the role of systemic administration of the AMPA receptor antagonist, 2,3‐dioxo‐6‐nitro‐7‐sulfamoyl‐benzo[f]quinoxaline (NBQX), on alcohol consumption using a model of binge‐like drinking, drinking in the dark (DID) and free‐access 2‐bottle choice (2BC) in male and female C57BL/6J and HAP mice.MethodsC57BL/6J mice were allowed free access to 20% (v/v) alcohol for 2 hours each day beginning 3 hours into the dark cycle for 4 days. On day 5, mice were intraperitoneally injected with one of 4 doses of NBQX (0, 3, 10, or 30 mg/kg; n = 10) 15 minutes before alcohol presentation and were given 4‐hour alcohol access (extended DID). HAP mice were given 24‐hour free access to 10% (v/v) alcohol and water for 19 days. On day 20, mice were intraperitoneally injected with one of 4 doses of NBQX (0, 3, 10, or 30 mg/kg; n = 9) 15 minutes before alcohol and water presentation.ResultsIn the first 2 hours of DID, at 30 mg/kg, male, but not female C57BL/6J or HAP, mice drank significantly less alcohol compared with controls and 30 mg/kg NBQX did not alter saccharin intake in the males. Although male HAP mice drank significantly less alcohol than female mice following 10 mg/kg NBQX, neither sex exhibited drinking that differed significantly from controls. NBQX did not reduce locomotor behavior at any dose, sex, or genotype.ConclusionsThese data suggest that AMPA receptors play a key role in modulating binge‐like alcohol consumption without altering saccharin consumption or general locomotion and that this effect is specific to sex and genotype.
A single‐center retrospective study of the clinical significance of chorionic bump at early stage of gestation
Authors: Lu Yu , Wu Yilun , Huang Fan , Ren Min 
Published: September 2020

AbstractProblemThe chorionic bump is a distinct rare sonographic abnormality. Until now, there is contradictory evidence about if it associates with poor pregnancy outcomes. We performed this retrospective study to provide additional clinical data to investigate the clinical significance of chorionic bump at early stage of pregnancy.Method of studyA single‐center retrospective study was performed using the sonographic and clinical data of the pregnant women who had antenatal checkup and childbirth at Shanghai First Maternal and Child Health Care Center from December 2018 to December 2019. Sonographic examination was performed by experts at 5‐10 weeks' gestation. Maternal age and gestational age matched controls from the same period were selected for analysis.ResultsWe observed 83 chorionic bump cases showing a prevalence of 0.33%. We found previous intrauterine operations and/or adverse maternal history posed a risk of having chorionic bump. In our cohort, chorionic bump associates with poor pregnancy outcomes. Poor pregnancy outcomes were more frequently found in the patients whose lesions were detected early (<56 days of pregnancy), or in the patients with the lesion relative sizes more than 40% of the sizes of the gestational sac, or in the patients with multiple lesions.ConclusionIntrauterine operations and/or adverse maternal history associate with an increased incidence of chorionic bump, which associates with poor pregnancy outcomes. Early detection, bigger relative size, and multiple lesions are factors likely leading to poor pregnancy outcomes.
Identifying haplotypes in recessive inherited retinal dystrophies using whole‐genome linked‐read sequencing
Authors: Repo Pauliina , Järvinen Reetta‐Stiina , Sankila Eeva‐Marja , Paavo Maarjaliis , Ellonen Pekka , Kivelä Tero T. , Turunen Joni A. 
Published: September 2020

AbstractConventional next‐generation sequencing methods, used in most gene panels, cannot separate maternally and paternally derived sequence information of distant variants. In recessive diseases, two or more equally plausible causative variants with unsolved phase information prevent accurate molecular diagnosis. In reality, close relatives might be unavailable for segregation analysis. Here, we utilized whole genome linked‐read sequencing to assign variants to haplotypes in two patients with inherited retinal dystrophies. Patient 1 with macular dystrophy had variants c.3442T>C, p.(Cys1148Arg), c.4209G>T, p.(Glu1403Asp), and c.1182C>T, p.(Cys394=) in CRB1, and Patient 2 with nonsyndromic retinitis pigmentosa had c.1328T>A, p.(Val443Asp) and c.3032C>G, p.(Ser1011*) in AHI1. The relatives were not available for genotyping. Using whole genome linked‐read sequencing we phased the variants to haplotypes providing genetic background for the retinal dystrophies. In future, when the price of sequencing methods that provides long‐read data decreases and their read‐depth and accuracy increases, they are probably considered the primary or adjunctive sequencing methods in genetic testing, allowing the immediate collection of phase information and thus obviating the need for the carrier testing and segregation analysis.
Pragmatic multicentre factorial randomized controlled trial testing measures to reduce surgical site infection in low‐ and middle‐income countries: study protocol of the FALCON trial
Authors:   NIHR Global Health Research Unit on Global Surgery
Published: September 2020

AbstractAimSurgical site infection (SSI) is the commonest postoperative complication worldwide, representing a major burden for patients and health systems. Rates of SSI are significantly higher in low‐ and middle‐income countries (LMICs) but there is little high‐quality evidence on interventions to prevent SSI in LMICs.MethodFALCON is a pragmatic, multicentre, 2 x 2 factorial, stratified randomized controlled trial, with an internal feasibility study, which will address the need for evidence on measures to reduce rates of SSI in patients in LMICs undergoing abdominal surgery. To assess whether either (1) 2% alcoholic chlorhexidine versus 10% povidone‐iodine for skin preparation, or (2) triclosan‐coated suture versus non‐coated suture for fascial closure, can reduce surgical site infection at 30‐days post‐surgery for each of (1) clean‐contaminated and (2) contaminated/dirty surgery. Patients with predicted clean‐contaminated or contaminated/dirty wounds with abdominal skin incision ≥ 5 cm will be randomized 1:1:1:1 between (1) 2% alcoholic chlorhexidine and noncoated suture, (2) 2% alcoholic chlorhexidine and triclosan‐coated suture, (3) 10% aqueous povidone–iodine and noncoated suture and (4) 10% aqueous povidone–iodine and triclosan‐coated suture. The two strata (clean‐contaminated versus contaminated/dirty wounds) are separately powered. Overall, FALCON aims to recruit 5480 patients. The primary outcome is SSI at 30 days, based on the Centers for Disease Control definition of SSI.ConclusionFALCON will deliver high‐quality evidence that is generalizable across a range of LMIC settings. It will influence revisions to international clinical guidelines, ensuring the global dissemination of its findings.
Is the influence of neoliberalism on development norms waning? Evidence from the Addis Ababa Action Agenda and the 2030 Agenda for Sustainable Development
Authors: Engberg‐Pedersen Lars 
Published: September 2020

AbstractMotivationThe term “neoliberalism” is often used inaccurately, making it difficult to assess its actual influence. Nevertheless, neoliberalism continues to dominate ideas about economic and social change. Few attempts have been made to analyse the influence of countervailing ideas which may imply a retreat from neoliberalism.PurposeThe article seeks to identify the central characteristics of neoliberalism and how these have changed through time. It looks at how compatible neoliberal ideas are with two 2015 agreements that set norms for international development co‐operation, the Addis Ababa Action Agenda and the 2030 Agenda for Sustainable Development.Approach and methodsThe compatibility of neoliberal ideas with the central tenets of the 2015 agreements is assessed. In particular, the process of setting a separate goal for reducing inequality in the 2030 Agenda for Sustainable Development is analysed. In addition, the Addis Ababa Action Agenda is compared with earlier agreements on financing for development.FindingsCentral ideas of the two agreements significantly challenge neoliberal ideas. While neoliberal thinking still influences policy and practice, its setback in international co‐operation reminds us to exercise caution when explaining social change as the result of neoliberal ideas.Policy ImplicationsElements of the two international agreements point decisively in new directions. Neoliberal influences on international norms may be diminishing. Hence other ideas now stand a better chance to influence norms, policies and practices in development.
Riparian forest subsidises the biomass of fish in a recently formed subtropical reservoir
Authors: Felden Juliana , González‐Bergonzoni Iván , Rauber Adelita Maria , da Luz Soares Marlon , Massaro Marthoni Vinicius , Bastian Rodrigo , Reynalte‐Tataje David Augusto 
Published: September 2020

AbstractRiparian forest may represent a key subsidy to aquatic food webs. While most research has been done in running waters, the origin of resources subsidising biomass and the role of riparian coverage in food webs remains largely unstudied in reservoirs. This research evaluated the role of forest riparian zones as food web subsidies in a recently formed reservoir of Ijuí River, Brazil. The diet of fish and the origin of carbon and nitrogen fuelling fish biomass was compared between littoral habitats with riparian forests and of open canopy. Sampling for stable isotopes of fish and basal resources and the application of bayesian mixing models showed that most of the fish production originates from terrestrial carbon in this recently formed reservoir. Moreover, an increasing terrestrial support to the biomass was found towards the riparian forest areas (subsidising c.a. 70% vs. around 57% of fish biomass in littoral areas of riparian forest and open canopy, respectively).This study remarked the role of riparian forest areas as energetic subsidises to aquatic ecosystems. Management actions in newly formed reservoirs should include preserving riparian forests to avoid losing natural ecosystem subsidies.
Nomogram predicting early neurological improvement in ischaemic stroke patients treated with endovascular thrombectomy
Authors: Zhang X. , Peng M. , Feng C. , Wang H. , Gong P. , Jiang T. , Xie Y. , Yang D. , Yuan K. , Chen J. , Li Y. , Liu D. , Liu X. , Xu G. 
Published: September 2020

Background and purposeEarly neurological improvement (ENI) after endovascular thrombectomy (EVT) has been associated with favorable outcomes. This study aimed to identify the optimal definition of ENI and develop a nomogram for predicting ENI after EVT in acute ischaemic stroke.MethodsPatients with EVT were enrolled from a multicenter registry as the training cohort. The receiver operating characteristic curve was used to estimate the optimal threshold for ENI at 24 h of EVT. Logistic regression analysis was utilized to generate the best‐fit nomogram for predicting ENI. The discrimination of the nomogram was assessed using the area under the receiver operating characteristic curve (AUC). An additional 447 patients from two stroke centers were prospectively recruited as the test cohort for validating the nomogram.ResultsA total of 612 patients with EVT were included in the training cohort. The optimal threshold for predicting 3‐month favorable outcome (modified Rankin Scale 0–2) was an improvement of the National Institutes of Health Stroke Scale (NIHSS) score by ≥6 points (AUC 0.875; sensitivity 79.5%; specificity 90.7%). Age, blood glucose, recanalization, symptomatic intracranial hemorrhage (sICH) and baseline Alberta Stroke Program Early Computed Tomography Score (ASPECTS) were independently associated with ENI, and were incorporated in the nomogram. The AUC of the nomogram was 0.795 in the training cohort and 0.752 in the test cohort.ConclusionsA reduction of NIHSS score ≥6 appeared to be the optimal definition of ENI. The nomogram composed of age, blood glucose, recanalization, sICH and baseline ASPECTS may predict the probability of ENI in ischaemic stroke patients treated with EVT.
Characterization of seizure susceptibility in Pcdh19 mice
Authors: Rakotomamonjy Jennifer , Sabetfakhri Niki P. , McDermott Sean L. , Guemez‐Gamboa Alicia 
Published: September 2020

AbstractObjectivePCDH19‐related epilepsy is characterized by a distinctive pattern of X‐linked inheritance, where heterozygous females exhibit seizures and hemizygous males are asymptomatic. A cellular interference mechanism resulting from the presence of both wild‐type and mutant PCDH19 neurons in heterozygous patients or mosaic carriers of PCDH19 variants has been hypothesized. We aim to investigate seizure susceptibility and progression in the Pchd19 mouse model.MethodsWe assessed seizure susceptibility and progression in the Pcdh19 mouse model using three acute seizure induction paradigms. We first induced focal, clonic seizures using the 6‐Hz psychomotor test. Mice were stimulated with increasing current intensities and graded according to a modified Racine scale. We next induced generalized seizures using flurothyl or pentylenetetrazol (PTZ), both γ‐aminobutyric acid type A receptor function inhibitors, and recorded latencies to myoclonic and generalized tonic‐clonic seizures.ResultsPcdh19 knockout and heterozygous females displayed increased seizure susceptibility across all current intensities in the 6‐Hz psychomotor test, and increased severity overall. They also exhibited shorter latencies to generalized seizures following flurothyl, but not PTZ, seizure induction. Hemizygous males showed comparable seizure incidence and severity to their wild‐type male littermates across all paradigms tested.SignificanceThe heightened susceptibility observed in Pcdh19 knockout females suggests additional mechanisms other than cellular interference are at play in PCDH19‐related epilepsy. Further experiments are needed to understand the variability in seizure susceptibility so that this model can be best utilized toward development of future therapeutic strategies for PCDH19‐related epilepsy.