bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and Fabrication of a Magnetite-based Polymer-supported Hybrid Nanocomposite: A Promising Heterogeneous Catalytic System Utilized in Known Palladium-assisted Coupling Reactions
Authors: Maleki Ali , Taheri-Ledari Reza , Ghalavand Reza 
Published: January 2020

Objective:
Herein, a novel heterogeneous catalytic system constructed of iron oxide and
palladium nanoparticles is presented. Firstly, a convenient synthetic pathway for the preparation of this
catalytic system is introduced, then the application of the fabricated nanocomposite in the Pd-catalyzed
C─C coupling reactions is monitored. High reaction yields (98%) have been obtained in short reaction
time, by using this catalytic system.

Materials and Methods:
Fe3O4/P4VP-Pd catalytic system was fabricated via an in situ method by 4-
vinylpyridine (4-VP). In this regard, all the essential structural analyses such as FT-IR, EDX, VSM, and
TGA have been performed on the Fe3O4/P4VP-Pd catalytic system to investigate its properties. The
spherical morphology of the NPs and their uniform size have also been studied by the SEM method.
Further, the reaction progress was controlled by thin-layer chromatography. Finally, NMR analysis was
used to identify the synthesized biphenyl pharmaceutical derivatives.

Results:
High efficiency of this catalytic system has been precisely investigated and the optimal conditions
were determined. The catalytic process is carried out in 20 min, under mild conditions (room temperature).
Then, the purification process is easily performed via magnetic separation of the catalyst NPs. After
completion of the synthesis reaction, the NPs were collected, washed, and reused several times.

Conclusion:
Among recently reported heterogeneous catalytic systems, Fe3O4/P4VP-Pd is recommended
due to its high catalytic performance, convenience of the preparation process, excellent biocompatibility,
economic benefits, and well reusability. Overall, in order to save time in the complex synthetic processes
and also prevent using so many chemical reagents and solvents for the purification process, the presented
catalytic system could be suitable for scaling up and applying for the industrial applications.
Alzheimer’s Disorder: Epigenetic Connection and Associated Risk Factors
Authors: Sharma Vivek Kumar , Mehta Vineet , Singh Thakur Gurjeet 
Published: January 2020

Abstract :The gene based therapeutics and drug targets have shown incredible and appreciable advances in alleviating human sufferings and complexities. Epigenetics simply means above genetics or which controls the organism beyond genetics. At present it is very clear that all characteristics of an individual are not determined by DNA alone, rather the environment, stress, life style and nutrition play a vital part in determining the response of an organism. Thus, nature (genetic makeup) and nurture (exposure) play equally important roles in the responses observed, both at the cellular and organism levels. Epigenetics influence plethora of complications at cellular and molecular levels that includes cancer, metabolic and cardiovascular complications including neurological (psychosis) and neurodegenerative disorders (Alzheimer’s disease, Parkinson disease etc.). The epigenetic mechanisms include DNA methylation, histone modification and non coding RNA which have substantial impact on progression and pathways linked to Alzheimer’s disease. The epigenetic mechanism gets deregulated in Alzheimer’s disease and is characterized by DNA hyper methylation, deacetylation of histones and general repressed chromatin state which alter gene expression at the transcription level by upregulation, downregulation or silencing of genes. Thus, the processes or modulators of these epigenetic processes have shown vast potential as a therapeutic target in Alzheimer’s disease.
Tyramine Derivatives as Potent Therapeutics for Type 2 Diabetes: Synthesis and In Vitro Inhibition of α-Glucosidase Enzyme
Authors: Bashir Muhammad A. , Javaid Kulsoom , Shaikh Muniza , Choudhary Muhammad I. , Siddiqui Hina 
Published: January 2020

Background:
Tyramine derivatives 3-16 were prepared and tested first time for their α-
glucosidase (Sources: Saccharomyces cerevisiae) inhibitory activity by using an in vitro mechanismbased
biochemical assay. All the compounds were found to be new, except compounds 3, 10-12 and
16.

Objective:
In continuation of our research to synthesize and identify potent inhibitors of α-glucosidase
enzyme, we intended to synthesize new inhibitors of α-glucosidase enzyme with enhanced efficacy in
order to provide the basis for the better treatment of the type-II diabetic.

Methods:
Tyramine (1) was allowed to react with a variety of aryl chlorides (2) to yield the corresponding
amides. Synthesized compounds were then purified through normal phase column chromatography.
Compounds 3-16 were then assessed for their α-glucosidase inhibitory activity in an in
vitro biochemical assay. The cytotoxicity of compounds 3-16 was determined by using 3T3 mouse
fibroblast cell lines.

Results:
Compounds 3-5, 8, 13, and 15-16 were found to be more active (IC50 = 103.1±0.46,
37.3±4.51, 56.7±4.2, 23.9±2.31, 43.6±2.88, 55.8±1.73, and 38.2±0.86 μM, respectively) than the
acarbose, the standard inhibitor of α-glucosidase enzyme, (IC50= 840.0±1.73 μM). To determine the
dissociation constants and mode of inhibition, the kinetic studies were also performed for compounds
4 and 8 (the most potent inhibitors). It was observed that compounds 4 and 8 possess noncompetitive
properties as the inhibitors of α-glucosidase. All the compounds were found to be noncytotoxic,
except 5 and 12 (IC50= 14.7± 0.24 and 6.6± 0.38 μM, respectively).

Conclusion:
The current study gives the facile synthesis and identification of potent inhibitors of α-
glucosidase. The new inhibitors reported here may be investigated further for the designing and
development of novel anti-diabetic agents.
Synthesis, In vitro, and Docking Analysis of C-3 Substituted Coumarin Analogues as Anticancer Agents
Authors: Thakur Anuradha , Kaur Kamalpreet , Sharma Praveen , Singla Ramit , Singh Sandeep , Jaitak Vikas 
Published: January 2020

Background:
Breast cancer (BC) is a leading cause of cancer-related deaths in women next to skin cancer. Estrogen receptors (ERs) play an important role in the progression of BC. Current anticancer agents have several drawbacks such as serious side effects and the emergence of resistance to chemotherapeutic drugs. As coumarins possess minimum side effect along with multi-drug reversal activity, it has a tremendous ability to regulate a diverse range of cellular pathways that can be explored for selective anticancer activity.

Objectives:
Synthesis and evaluation of new coumarin analogues for anti-proliferative activity on human breast cancer cell line MCF-7 along with exploration of binding interaction of the compounds for ER-α target protein by molecular docking.

Method:
In this study, the anti-proliferative activity of C-3 substituted coumarins analogues (1-17) has been evaluated against estrogen receptor-positive MCF-7 breast cancer cell lines. Molecular interactions and ADME study of the compounds were analyzed by using Schrodinger software.

Results:
Among the synthesized analogues 12 and 13 show good antiproliferative activity with IC50 values 1and 1.3 µM respectively. Molecular docking suggests a remarkable binding pose of all the seventeen compounds. Compounds 12 and 13 were found to exhibit dock score of -4.10 kcal/mol and -4.38 kcal/mol respectively.

Conclusion:
Compounds 12 and 13 showed the highest activity followed by 1 and 5. ADME properties of all compounds were in the acceptable range. The active compounds can be taken for lead optimization and mechanistic interventions for their in vivo study in the future.
Cancer Fighting SiRNA-RRM2 Loaded Nanorobots
Authors: Sharma Arjun , Kumar Pravir , Ambasta Rashmi K. 
Published: January 2020

Background:
Silencing of several genes is critical for cancer therapy. These
genes may be apoptotic gene, cell proliferation gene, DNA synthesis gene, etc. The two
subunits of Ribonucleotide Reductase (RR), RRM1 and RRM2, are critical for DNA synthesis.
Hence, targeting the blockage of DNA synthesis at tumor site can be a smart mode
of cancer therapy. Specific targeting of blockage of RRM2 is done effectively by SiRNA.
The drawbacks of siRNA delivery in the body include the poor uptake by all kinds of cells,
questionable stability under physiological condition, non-target effect and ability to trigger
the immune response. These obstacles may be overcome by target delivery of siRNA at the
tumor site. This review presents a holistic overview regarding the role of RRM2 in controlling
cancer progression. The nanoparticles are more effective due to specific characteristics
like cell membrane penetration capacity, less toxicity, etc. RRM2 have been found to be
elevated in different types of cancer and identified as the prognostic and predictive marker
of the disease. Reductase RRM1 and RRM2 regulate the protein and gene expression of
E2F, which is critical for protein expression and progression of cell cycle and cancer. The
knockdown of RRM2 leads to apoptosis via Bcl2 in cancer. Both Bcl2 and E2F are critical
in the progression of cancer, hence a gene that can affect both in regulating DNA replication
is essential for cancer therapy.

Aim:
The aim of the review is to identify the related gene whose silencing may inhibit cancer
progression.

Conclusion:
In this review, we illuminate the critical link between RRM-E2F, RRM-Bcl2,
RRM-HDAC for the therapy of cancer. Altogether, this review presents an overview of all
types of SiRNA targeted for cancer therapy with special emphasis on RRM2 for controlling
the tumor progression.
Facilitators and Barriers to Recruiting Ambulatory Oncology Practices Into a Large Multisite Study: Mixed Methods Study
Authors: Manojlovich Milisa , Bedard Louise , Griggs Jennifer J , McBratnie Michaella , Mendelsohn-Victor Kari , Friese Christopher R 
Published: January 2020

Background
Practice-based research is essential to generate the data necessary to understand outcomes in ambulatory oncology care. Although there is an increased interest in studying ambulatory oncology care, given the rising patient volumes and complexity in those settings, little guidance is available on how best to recruit ambulatory oncology practices for research.

Objective
This paper aimed to describe the facilitators and barriers to recruiting ambulatory oncology practices into a large multisite study.

Methods
Using a mixed methods design, we sought to recruit 52 ambulatory oncology practices that have participated in a state-wide quality improvement collaborative for the quantitative phase. We used 4 domains of the Consolidated Framework for Implementation Research (CFIR) to describe facilitators and barriers to recruitment.

Results
We successfully recruited 28 of the 52 collaborative-affiliated practices, collecting survey data from 2223 patients and 297 clinicians. Intervention attributes included multimodal outreach and training activities to assure high fidelity to the data collection protocol. The implementation process was enhanced through interactive training and practice-assigned champions responsible for data collection. External context attributes that facilitated practice recruitment included partnership with a quality improvement collaborative and the inclusion of a staff member from the collaborative in our team. Key opinion leaders within each practice who could identify challenges to participation and propose flexible solutions represented internal context attributes. We also reported lessons learned during the recruitment process, which included navigating diverse approaches to human subjects protection policies and understanding that recruitment could be a negotiated process that took longer than anticipated, among others.

Conclusions
Our experience provides other researchers with challenges to anticipate and possible solutions for common issues. Using the CFIR as a guide, we identified numerous recruitment barriers and facilitators and devised strategies to enhance recruitment efforts. In conclusion, researchers and clinicians can partner effectively to design and implement research protocols that ultimately benefit patients who are increasingly seeking care in ambulatory practices.
An Automated Blood Pressure Display for Self-Measurement in Patients With Chronic Kidney Disease (iHealth Track): Device Validation Study
Authors: Mazoteras-Pardo Victoria , Becerro-De-Bengoa-Vallejo Ricardo , Losa-Iglesias Marta Elena , López-López Daniel , Calvo-Lobo César , Rodríguez-Sanz David , Martínez-Jiménez Eva María , Palomo-López Patricia 
Published: January 2020

Background
Hypertension is a global public health issue and is closely related to chronic kidney disorder (CKD). In people with CKD, strict monitoring of blood pressure is an important part of therapy.

Objective
The aim of this research was to validate the iHealth Track blood pressure monitoring device for patients with CKD according to the European Society of Hypertension International Protocol 2010 (ESH-IP2).

Methods
In total, 33 patients who received hemodialysis in Plasencia participated in the study. There were 9 successive measurements made, which conformed to the ESH-IP2. We calculated the differences between the standard reference device (Omron M3 Intellisense) and the test device (iHealth Track) for blood pressure and heart rate values. For 99 total comparisons of paired measurements, we classified differences into various categories (≤5 mmHg, ≤10 mmHg, and ≤15 mmHg for blood pressure; ≤3, ≤5, and ≤8 beats per minute for heart rate).

Results
In 90 of 99 systolic blood pressure and 89 of 99 diastolic blood pressure comparisons between the devices, measurement differences were within 5 mmHg. In 81 of 99 heart rate comparisons between the devices, measurement differences were within 3 beats per minute. The mean differences between the test and reference standard measurements were 3.27 (SD 2.99) mmHg for systolic blood pressure, 3.59 (SD 4.55) mmHg for diastolic blood pressure, and 2.18 (SD 2.75) beats per minute for heart rate.
We also observed that for both systolic and diastolic blood pressure, 31 of 33 participants had at least two of three comparisons between the devices with measurement differences less than 5 mmHg. For heart rate, 28 of 33 patients had at least two of three comparisons between the devices with measurement differences less than 3 beats per minute.

Conclusions
To our knowledge, this is the first study to show that iHealth Track meets the requirements of the ESH-IP2 in patients with CKD. Therefore, the iHealth Track is suitable for use in renal patients.
Effect of Age on the Initiation of Biologic Agent Therapy in Patients With Inflammatory Bowel Disease: Korean Common Data Model Cohort Study
Authors: Choi Youn I , Kim Yoon Jae , Chung Jun-Won , Kim Kyoung Oh , Kim Hakki , Park Rae Woong , Park Dong Kyun 
Published: January 2020

Background
The Observational Health Data Sciences and Informatics (OHDSI) network is an international collaboration established to apply open-source data analytics to a large network of health databases, including the Korean common data model (K-CDM) network.

Objective
The aim of this study is to analyze the effect that age at diagnosis has on the prognosis of inflammatory bowel disease (IBD) in Korea using a CDM network database.

Methods
We retrospectively analyzed the K-CDM network database from 2005 to 2015. We transformed the electronic medical record into the CDM version 5.0 used in OHDSI. A worsened IBD prognosis was defined as the initiation of therapy with biologic agents, including infliximab and adalimumab. To evaluate the effect that age at diagnosis had on the prognosis of IBD, we divided the patients into an early-onset (EO) IBD group (age at diagnosis <40 years) and a late-onset (LO) IBD group (age at diagnosis ≥40 years) with the cutoff value of age at diagnosis as 40 years, which was calculated using the Youden index method. We then used the logrank test and Cox proportional hazards model to analyze the effect that age at diagnosis (EO group vs LO group) had on the prognosis in patients with IBD.

Results
A total of 3480 patients were enrolled. There was 2017 patients with ulcerative colitis (UC) and 1463 with Crohn’s disease (CD). The median follow up period was 109.5 weeks. The EO UC group was statistically significant and showed less event-free survival (ie, experiences of biologic agents) than the LO UC group (P<.001). In CD, the EO CD group showed less event-free survival (ie, experiences of biologic agents) than the LO CD group. In the Cox proportional hazard analysis, the odds ratio (OR) of the EO UC group on experiences of biologic agents compared with the LO UC group was 2.3 (95% CI 1.3-3.8, P=.002). The OR of the EO CD group on experiences of biologic agents compared with the LO CD group was 5.4 (95% CI 1.9-14.9, P=.001).

Conclusions
The EO IBD group showed a worse prognosis than the LO IBD group in Korean patients with IBD. In addition, this study successfully verified the CDM model in gastrointestinal research.
Use of Mental Health Apps by Patients With Breast Cancer in the United States: Pilot Pre-Post Study
Authors: Chow Philip I , Showalter Shayna L , Gerber Matthew , Kennedy Erin M , Brenin David , Mohr David C , Lattie Emily G , Gupta Alisha , Ocker Gabrielle , Cohn Wendy F 
Published: January 2020

Background
Nearly half of the patients with breast cancer experience clinically significant mental distress within the first year of receiving their cancer diagnosis. There is an urgent need to identify scalable and cost-efficient ways of delivering empirically supported mental health interventions to patients with breast cancer.

Objective
The aim of this study was to evaluate the feasibility of in-clinic recruitment for a mobile phone app study and to evaluate the usability and preliminary impact of a suite of mental health apps (IntelliCare) with phone coaching on psychosocial distress symptoms in patients recently diagnosed with breast cancer.

Methods
This pilot study adopted a within-subject, 7-week pre-post study design. A total of 40 patients with breast cancer were recruited at a US National Cancer Institute–designated clinical cancer center. Self-reported distress (Patient Health Questionnaire-4) and mood symptoms (Patient-Reported Outcomes Measurement Information System depression and anxiety scales) were assessed at baseline and postintervention. App usability was assessed at postintervention.

Results
The minimum recruitment threshold was met. There was a significant decrease in general distress symptoms, as well as symptoms of depression and anxiety, from baseline to postintervention. Overall, participants reported high levels of ease of app use and learning. Scores for app usefulness and satisfaction were reinforced by some qualitative feedback suggesting that tailoring the apps more for patients with breast cancer could enhance engagement.

Conclusions
There is a dire need for scalable, supportive interventions in cancer. The results from this study inform how scalable mobile phone–delivered programs with additional phone support can be used to support patients with breast cancer.

International Registered Report Identifier (IRRID)
RR2-10.2196/11452
Analisa Pergeseran Magnetic Domain Wall pada Lapisan Tipis Free Layer Co/Pd terhadap Pengaruh Dimensi Sampel (Halaman 55 s.d. 58)
Authors: Salamah Umi , Suharyadi Edi 
Published: January 2020

Telah dilakukan analisa pergeseran magnetic domain wall pada lapisan tipis free layer Co/Pd dengan menggunakan software Object Oriented Micromagnetic Framework (OOMMF) berdasarkan persamaan Landau-Lifshitz Gilbert (LLG). Analisa dilakukan pada ukuran 100x100 nm dengan memvariasikan ukuran ketebalan yaitu 1 nm, 3 nm, dan 5 nm. Dengan pemberian medan eksternal dari arah sumbu (+)z, magnet saturasi dicapai pada 31.290 Oe untuk ketebalan 1 nm, 30.940 Oe pada ketebalan 3 nm, dan 30.660 Oe pada ketebalan 5 nm. Selanjutnya dilakukan analisa dengan variasi ukuran pada ketebalan 5 nm yaitu 100x100 nm, 300x100 nm dan 500x100 nm. Magnet saturasi pada ukuran 300x100 nm dicapai pada pemberian medan eksternal sebesar 30.970 Oe dan magnet saturasi pada ukuran 500x100 nm dicapai pada pemberian medan eksternal sebesar 31.040 Oe.
Optimasi Kinerja Primitive Root Diffuser (PRD) dengan Teknik Sisipan Resonator Jamak (Halaman 25 s.d. 29)
Authors: Ahmad Fahrudin , - Harjana , - Suparmi , Yahya Iwan 
Published: January 2020

Telah dilakukan kajian untuk meningkatkan kinerja primitive roots diffuser (PRD) dengan model standar berbentuk Skyline dengan jumlah elemen 5x8. Teknik modifikasi yang telah diterapkan adalah penyisipan rangkaian resonator seperempat panjang gelombang dengan kedalaman yang bersesuaian dengan masing-masing elemen PRD. Pengujian dilaksanakan dengan metode interrupted noise mengacu kepada prosedur standar ISO 3382 untuk mendapatkan nilai waktu dengung T30 dan T20. Adapun respon spasial dari PRD yang dikembangkan disimulasikan dengan perangkat lunak AFMG Reflex. Hasil pengujian menunjukkan bahwa penambahan rangkaian resonator jamak berhasil mengurangi nilai waktu dengung rerata sebesar 0,78 dan 1,83 sekon berturut-turut untuk T30 dan T20 pada bentang frekuensi rendah. Di samping itu pemakaian resonator memperbaiki respon spasial omnidireksional PRD.
EFEKTIVITAS PENEGAKAN HUKUM DI BIDANG KEKAYAAN INTELEKTUAL OLEH PENYIDIK PEGAWAI NEGERI SIPIL
Authors: Citrawan Harison , Rasyidi Achmad Fikri 
Published: January 2020

Kajian ini mencoba menggambarkan efektivitas penegakan hukum oleh PPNS di bidang kekayaan intelektual (KI). Dengan menggunakan psychological type of the cognitive function, ditemukan bahwa: Pertama, secara internal PPNS KI (KI) sudah menjalankan tugas dan fungsi PPNS KI, meskipun belum pada level ideal. Faktor-faktor internal yang memengaruhi hal tersebut yakni: (i) belum terdapat struktur PPNS KI di Kantor Wilayah Hukum dan HAM, dan (ii) penempatan PPNS ke dalam jabatan atau posisi tertentu yang tidak relevan dengan tugas dan wewenang PPNS. Kedua, secara eksternal berdasarkan tinjauan normatif, dipahami bahwa penegakan hukum KI dapat menempuh beberapa jalur. Adapun normativitas kewenangan PPNS yang tidak mencakup ranah mediasi penal justru menyebabkan kewenangan mereka menjadi sangat terbatas.