bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faktor Yang Mempengaruhi Keputusan Mahasiswa S1 Ekonomi Islam Fakultas Ekonomi dan Bisnis Universitas Airlangga Belum Menjadi Nasabah Bank Syariah
Authors: Johan Mega Nilasari , Ratnasari Ririn Tri 
Published: October 2020

This research aims to determine the factors that influence the decision of Students of Islamic Economics FEB UNAIR not selected as Syariah Bank’s Customer.This research used quantitative methods through exploratory factor analysis. Characteristic of the research population are students of Islamic Economics UNAIR who following the active class. The number of samples in pre eliminary test by conducting a written interview by 25 respondents, and main test required 100 respondents. The sampling technique used is probability sampling. Sampling was done using simple random sampling.Based on the results of the study indicate that there are four factors that affect the decision of Students of Islamic Economics FEB UNAIR. The four factors as a result of reduction of processing factor analysis. These four factors named by factor of the brand image, product knowledge, spurious loyalty, service experience.Advice for the Syariah Bank are improves service experience for every remittance transactions by ontime, Syariah Bank offers interesting sales promotion to get customers, more socialization about negative impact of riba, not burden charge for every transactions in ATM or online banking. Advice for the next researcher, can analys factors made from this research influencing other variabel that decision muslim students S1 FEB UNAIR have not been Syariah Bank’s customer yet, for the second next research, make the factors in this research being exogen variables that influenced muslim consumen behavior to Syariah Bank.
Implementasi Konsumsi Islami Pada Pengajar Pondok Pesantren (Studi Kasus Pada Pengajar Pondok Pesantren Al Aqobah Kecamatan Diwek Kabupaten Jombang)
Authors: Baidhowi Bagus , Zaki Irham 
Published: October 2020

This study aims to determine the application of Islamic consumption by Al Aqobah Boarding School teacher in Diwek Subdistrict, Jombang District.This study used a qualitative approach with descriptive case study method. The population characteristics of this study are the teachers of Al Aqobah Boarding School in Diwek Subdistrict, Jombang District. The teachers of Al Aqobah Boarding School who know and understand the consumption according to Islam are people who implement Islamic consumption in his life, the teacher/ustadz and ustadzah who has been teaching at Al Aqobah boarding school at least 2 years. The number of samples in this study was six informants. The sampling technique used was purposive sampling.Based on the results of this study showed that Al Aqobah boarding school teacher in Diwek Subdistrict, Jombang District, has implemented the Islamic consumption legally (halal); they are not extravagant not only in spending wealth but also in living luxury and showing assets. They can also make the balance system between worldly and hereafter consumption.Moreover, the suggestion for all of people in Al Aqobah boarding school and also the teachers are expected to continue teaching the consumption which is true to Islam, apply in everyday life, and provide appropriate examples to the students. For further research, it is expected to examine the same topic with more in depth details about the implementation of Islamic consumption on other aspects that are more specific.
Implementasi Sifat Amanah Pengelola Koperasi Pondok Pesantren (Studi Kasus Pada Pengelola Koperasi Pondok Pesantren Qomaruddin Kecamatan Bungah Kabupaten Gresik
Authors: Abiyoga Firdaus Arfianandy , Zaki Irham 
Published: October 2020

A Muslim who works as a form of workship to Allah SWT make attempts to obtain wealth by means of the lawful and good. As well as within the organization, a Muslim who gained the trust of the other party will always manage cooperatives by prioritizing and applying traits according to traits owned by Rasulallah, one of which is the trusthworthy traits and is able to provide a positive influence to others within the organization.The research method used is case study with a qualitative descriptive approach. This study uses interviews in primary data collection. The scope of research is limited to the focus on the cooperative manager of Qomaruddin boarding school Sampurnan Bungah in Gresik and find answers on how to implement the trustworthy traits of Rasulalllah on the management of the cooperative.The result of this research is the implementation of the trustworthy traits of Rasulallah SAW has already been implemented properly by the cooperative manager of the cooperative boarding school in the form of cooperative management in accordance with Islamic principle, because the cooperative management fullfilled with the 3 indicators such as responsibility, trusworthiness and transparency so that the growth and development of cooperative boarding school survived until today. The manager of the boarding school cooperative that implements the trustworthy traits of Rasulallah able to make policy and ethical Islamic system which resulted in an Islamic organization. The cooperative management has implemented the trustworthy traits correctly, by implementing those trustworthy traits, kopontren obtain the benefit. Kopontren manager interpret the business benefits based on the blessing of sustenance and pleasure of Allah SWT from the management as well as the ability and the sincerity to provide benefits to many parties.
Increased Association of Deamidated αA-N101D with Lens Membrane of Transgenic αAN101D vs. Wild Type αA Mice: Potential Effects on Intracellular Ionic Imbalance and Membrane Disorganization&nbsp;
Authors: Srivast Om , Srivast Kiran , Joseph Roy , Wilson Landon 
Published: October 2020

Abstract
We have generated two mouse models, in one by inserting the human lens αAN101D transgene in CRYαA N101D mice, and in the other by inserting human wild-type αA-transgene in CRYαA WT mice. The CRYαA N101D mice developed cortical cataract at about 7-months of age relative to CRYαA WT mice. The objective of the study was to determine the following relative changes in the lenses of CRYαA N101D - vs. CRYαA WT mice: age-related changes with specific emphasis on protein insolubilization, relative membrane-association of αA N101D vs. WTαA proteins, and changes in intracellular ionic imbalance and membrane organization. Methods: Lenses of varying ages from CRYαA WT and CRYαA N101D mice were compared for an age-related protein insolubilization. The relative lens membrane-association of the αAN101D- and WTαA proteins in the two types of mice was determined by immunohistochemical-, immunogold-labeling-, and western blot analyses. The relative levels of membrane-binding of recombinant αA N101D - and WTαA proteins was determined by an in vitro assay, and the levels of intracellular Ca 2+ uptake and Na, K-ATPase mRNA were determined in the cultured epithelial cells from lenses of the two types of mice. Results: Compared to the lenses of CRYαA WT , the lenses of CRYαA N101D mice exhibited: (A) An increase in age-related protein insolubilization beginning at about 4-months of age. (B) A greater lens membrane-association of αAN101D- relative to WTαA protein during immunogold-labeling- and western blot analyses, including relatively a greater membrane swelling in the CRYαA N101D lenses. (C) During in vitro assay, the greater levels of binding αAN101D- relative to WTαA protein to membranes was observed. (D) The 75% lower level of Na, K-ATPase mRNA but 1.5X greater Ca 2+ uptake was observed in cultured lens epithelial cells of CRYαA N101D- than those of CRYαA WT mice. Conclusions: The results show that an increased lens membrane association of αA N101D - - relative WTαA protein in CRYαA N101D mice than CRYαA WT mice occurs, which causes intracellular ionic imbalance, and in turn, membrane swelling that potentially leads to cortical opacity.
Assessment of Optometrists’ Knowledge, Skills and Practice on Cataract: A Cross-Sectional Study from Kisumu County, Western Kenya
Authors: Muma Shadrack , Obonyo Stephen 
Published: October 2020

Abstract
Background: The quality of life can be impacted negatively by blindness arising from cataract. The total prevalence of blindness in Kenya is estimated at 0.7%, however cataract contributes almost half (43%) of the total blindness in Kenya. Optometrists are well placed to assess and refer cataract patients. However, little is known on optometrists’ skills, practice and knowledge. Therefore, this study was designed to assess optometrists’ knowledge, skill and practice on cataract in Kisumu, Kenya. Methods: A cross-sectional study design was used. The study was conducted from June 2019 to August 219 using self-administered questionnaire. Basic socio-demographic characteristics were collected and participants’ knowledge, skills and practice on cataract were investigated. The primary outcome measure was the proportions of participants who identified the questions related to knowledge, skills and practice on cataract. Chi-square analysis was performed to assess the association between demographic characteristics of participants with practice, knowledge and skills. Results: A total of 49 optometrists with a mean age of 30.4 years and mean duration of practice of 1-10 years were interviewed. Most optometrists had good knowledge on various aspects of cataract. For example (98%) had a good knowledge on the types of cataract. Almost three quarter (75.5%) of the optometrists reported that they could diagnose cataract correctly based on skills. However, half (57.1%) of the optometrists could not identify nuclear cataract. Being a self reported practice and not an observed practice, most optometrists (61.2%) reported that they did not screen patients aged 40 years and above for cataract. Almost half (52.6%) of the optometrists reported that they did a routine eye examination however, they could not justify the significance of examining the crystalline lens for patient above 40 years. Conclusion The study established that despite the good level of knowledge among optometrist on cataract, there exist a gap on skills and practice. The results of this study calls for more clinical based activities among optometrists. This will eases diagnosis of cataract and its management with an aim to reduce the burden in Kenya.
Relationship between structural and functional changes in glaucomatous eyes: A multifocal electroretinogram study
Authors: Tanaka Hiroki , Ishida Kyoko , Ozawa Kenji , Ishihara Takuma , Sawada Akira , Mochizuki Kiyofumi , Yamamoto Tetsuya 
Published: October 2020

Abstract
Background:

The nasal to temporal amplitudes ratio (N/T) of multifocal electroretinography (mfERG) scans measured within 5° of the macula can be used to detect glaucomatous change. The photopic negative response (PhNR) of mfERG elicited by a circular stimulus centered on the fovea was significantly reduced in eyes with glaucoma. The PhNR to B-wave ratio (PhNR/B) is the optimal measure of the PhNR. However, clinical superiority for evaluating glaucoma patients has not been determined between N/T and PhNR/B yet.

Methods: For morphological assessments, ganglion cell complex (GCC) in six regions and the average were measured by optical coherence tomography (OCT). For functional assessment, Humphrey visual fields (VF) with mean sensitivities (MT) and mfERG scans with parameters of N/T and the multifocal photopic negative response to B-wave ratio (mfPhNR/B) were measured. Sixty-nine eyes of forty-four glaucoma patients were included and correlations between mfERG parameters and OCT or VF parameters were evaluated.

Results: The mean age of patients was 59.4 years. The mean deviation for all eyes obtained with the VF 30-2 and VF 10-2 was -7.00 and -6.31 dB, respectively. Significant correlations between GCC thickness or VF parameter and the N/T were found, especially in the inferior and inforotemporal retinal areas corresponding to superior and superonasal VF sectors (GCC vs N/T; coefficient = -7.916 and -7.857, and MT vs N/T ; coefficient = -4.302 and -4.437, in the inferior and inforotemporal retinal areas, respectively, all p values < 0.05). However, similar associations were not obtained between mfPhNR/B and OCT or VF parameters. The mfPhNR/B only in the inferotemporal sector was significantly correlated with the average thickness of GCC (coefficient = 4.823, P = 0.012).

Conclusions: The N/T is better parameter than PhNR/B for the assessment of glaucomatous eyes in the current study’s measurement conditions. A future study modifying the stimuli and amplitudes to obtain the spatial correspondence to OCT and VF measurement will be required to evaluate the value of mfERG.
Bloodstream Infections caused by Klebsiella pneumoniae and Serratia marcescens isolates co-harboring NDM-1 and KPC-2.
Authors: Bes Taniela , Nagano Debora , Martins Roberta , Marchi Ana Paula , Neto Lauro Perdigão , Higashino Hermes , Prado Gladys , Guimaraes Thais , Levin Anna S , Costa Silvia 
Published: October 2020

Abstract
Carbapenem-resistant Enterobacteriaceae are a worldwide health problem and isolates carrying both blaKPC-2 and blaNDM-1 are unusual. Here we describe the microbiological and clinical characteristics of five cases of bloodstream infections (BSI) caused by carbapenem-resistant Klebsiella pneumoniae and Serratia marcescens having both blaKPC-2 and blaNDM-1. Of the five blood samples, three are from hematopoietic stem cell transplantation patients, one from a renal transplant patient, and one from a soft tissue surgical patient. All patients lived in low-income neighbourhoods and had no travel history. Despite antibiotic treatment, four of five patients died. The phenotypic susceptibility assays showed that meropenem added either EDTA, phenylboronic acid (PBA) or both, increased the zone of inhibition in comparison to meropenem alone. Molecular tests showed the presence of blaKPC-2 and blaNDM-1 genes. K. pneumoniae isolates were assigned to ST258 or ST340 by whole genome sequencing. This case-series showed a high mortality among patients with BSI caused by Enterobacteriae harbouring both carbapenemases. The detection of carbapenemase-producing isolates carrying both blaKPC-2 and blaNDM-1 remains a challenge when using only phenotypic assays. Microbiology laboratories must be alert for K. pneumoniae isolates producing both KPC-2 and NDM-1.
Luteolin Inhibits Respiratory Syncytial Virus Replication by Regulating the MiR-155/SOCS1/STAT1 Signaling Pathway
Authors: Wang Saisai , Ling Yiting , Yao Yuanyuan , Zheng Gang , Chen Wenbin 
Published: October 2020

Abstract
Background: Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infection in infants, children, immunocompromised adults, and elderly individuals. Currently, there are few therapeutic options available to prevent RSV infection. The present study aimed to investigate the effects of luteolin on RSV replication and the related mechanisms. Material and methods: We pretreated cells and mice with luteolin before infection with RSV, the virus titer, expressions of RSV-F, interferon (IFN)-stimulated genes (ISGs), and production of IFN-α and IFN-β were determined by plaque assay, RT-qPCR, and ELISA, respectively. The activation of Janus kinase (JAK)-signal transducer and activator of transcription 1 (STAT1) signaling pathway was detected by Western blotting and luciferase assay. Proteins which negatively regulates STAT1 was determined by Western blotting. Then cells were transfected with suppressor of cytokine signaling 1 (SOCS1) plasmid and virus replication and ISGs expression was determined. Luciferase reporter assay and Western blotting was performed to detect the relationship between SOCS1 and miR-155. Results: Luteolin inhibited RSV replication, as shown by the decreased viral titer and RSV-F mRNA expression both in vitro and in vivo. The antiviral activity of luteolin was attributed to the enhanced phosphorylation of STAT1, resulting in the increased production of ISGs. Further study showed that SOCS1 was downregulated by luteolin and SOCS1 is a direct target of microRNA-155 (miR-155). Inhibition of miR-155 rescued luteolin-mediated SOCS1 downregulation, whereas upregulation of miR-155 enhanced the inhibitory effect of luteolin. Conclusion: Luteolin inhibits RSV replication by regulating the miR-155/SOCS1/STAT1 signaling pathway.
Effect of capsular tension ring implantation on capsular stability after phacoemulsification in patients with weak zonules:a randomized controlled trail.
Authors: Yang Shangfei , Jiang Hui , Nie Kailai , Feng Liwen , Fan Wei 
Published: October 2020

Abstract
Background: Patients who had previously undergone pars plana vitrectomy (PPV) or who had severe myopia may have weaker zonules, for which a capsular tension ring (CTR) implantation is still controversial. This study is to test the effect of CTR implantation on capsular stability after phacoemulsification in those patients. Methods: A total of 42 patients who underwent phacoemulsification and received an intraocular lens (IOL) were randomized to undergo CTR implantation or not. The primary outcomes were uncorrected distant visual acuity (UDVA), best corrected distant visual acuity (BCDVA), refractive prediction error, the area of anterior capsulorhexis, and IOL inclination angle. Follow-up visits were conducted postoperatively at 1 day, 1 week, 1 month and 3 months. Outcomes were compared between all CTR and control patients, as well as between subgroups who had previously undergone PPV or who had severe myopia. Results: Surgery significantly improved UDVA and BCDVA to similar extents in CTR and control patients, and refraction prediction error was similar between the two groups at all follow-up times. At 3 months after surgery, the area of anterior capsulorhexis was significantly larger in CTR patients than in controls (p = 0.0199). These differences were also significant between the subgroups of patients with strong myopia. Vertical IOL inclination was less within CTR groups at 3 months after surgery, especially in patients with severe myopia(p=0.0286). At 1 week postoperatively, the proportion of individuals whose posterior lens capsule that had completely adhered to the posterior IOL surface was significantly higher among CTR patients (p = 0.023). No serious surgical complications were observed. Conclusion: CTR implantation can benefit cataract patients with weak zonules by maintaining the shape of the capsular bag, reducing capsule shrinkage and stabilizing IOL inclination.
Protective CD8+ T-cell response against Hantaan virus infection induced by immunization with designed linear multi-epitope peptides in HLA-A2.1/Kb transgenic mice
Authors: Ma Ying , Tang Kang , Zhang Yusi , Zhang Chunmei , Cheng Linfeng , Zhang Fanglin , Zhuang Ran , Jin Boquan , Zhang Yun 
Published: October 2020

Abstract
Background: An effective vaccine that prevents disease caused by hantaviruses is a global public health priority, but up to now, no vaccine has been approved for worldwide use. Therefore, novel vaccines with high prophylaxis efficacy are urgently needed.Methods: Herein, we designed and synthesized Hantaan virus (HTNV) linear multi-epitope peptide consisting of HLA-A*02-restricted HTNV cytotoxic T cell (CTL) epitope and pan HLA-DR-binding epitope (PADRE), and evaluated the immunogenicity, as well as effectiveness, of multi-epitope peptides in HLA-A2.1/Kb transgenic mice with interferon (IFN)-γ enzyme-linked immunospot assay, cytotoxic mediator detection, proliferation assay and HTNV-challenge test.Results: The results showed that a much higher frequency of specific IFN-γ-secreting CTLs, high levels of granzyme B production, and a strong proliferation capacity of specific CTLs were observed in splenocytes of mice immunized with multi-epitope peptide than in those of a single CTL epitope. Moreover, pre-immunization of multi-epitope peptide could reduce the levels of HTNV RNA loads in the liver, spleen and kidneys of mice, indicating that specific CTL responses induced by multi-epitope peptide could reduce HTNV RNA loads in vivo.Conclusions: This study may provide an important foundation for the development of novel peptide vaccines for HTNV prophylaxis.
OphthatomeTM: An integrated knowledgebase of ophthalmic diseases for translating vision research into the clinic
Authors: Raj Praveen , Tejwani Sushma , Sudha Dandayudhapani , B Muthu Narayanan , Thangapandi Chandrasekar , Das Sankar , J Somasekar , Mangalapudi Susmithasane , Kumar Durgesh , Pindipappanahalli Narendra , Shetty Rohit , Ghosh Arkashubra , Kumaramanickavel Govindasamy , Chaudhuri Amitabha , Nagaswamy Soumittra 
Published: October 2020

Abstract
Background: Medical big data analytics has revolutionized the human healthcare system by introducing processes that facilitate rationale clinical decision making, predictive or prognostic modelling of disease progression and management, disease surveillance, impact on public health and research. Although, the electronic medical records (EMR) system is the digital storehouse of rich medical data of a large patient cohort collected over many years, the data lack sufficient structure to be of clinical value for applying deep learning methods and advanced analytics to improve disease management at an individual patient level or for the discipline in general. Ophthatome TM captures data contained in retrospective electronic medical records between September 2012 and January 2018 to facilitate translational vision research through a knowledgebase of eye diseases. Methods: The electronic medical records data from Narayana Nethralaya recorded in the MS-SQL database was mapped and programmatically transferred to MySQL. The captured data was manually curated to preserve data integrity and accuracy. The data is stored in MySQL database management system for ease of visualization, advanced search functions and other knowledgebase applications. Results: Ophthatome TM is a comprehensive and accurate knowledgebase of ophthalmic diseases containing curated clinical, treatment and imaging data of 581,466 ophthalmic cases from the Indian population, recorded between September 2012 and January 2018. Ophthatome TM provides filters and Boolean searches with operators and modifiers that allow selection of specific cohorts covering 524 distinct ophthalmic disease types and 1800 disease sub-types across 35 different anatomical regions of the eye. The availability of longitudinal data for about 300,000 subjects provides additional opportunity to perform clinical research on disease progression and management including drug response and treatment outcome. The knowledgebase captures eye diseases in a genetically diverse population providing opportunity to study genetic and environmental factors contributing to or influencing eye diseases. Conclusion: Ophthatome TM will accelerate clinical, genomic, pharmacogenomic and advanced translational research on ophthalmic diseases.