bluuebunny/crossref_metadata_2025_split huggingface dataset:
PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models
Authors: Hernandez Ariel L. , Young Christian D. , Bian Li , Weigel Kelsey , Nolan Kyle , Frederick Barbara , Han Gangwen , He Guanting , Devon Trahan G. , Rudolph Michael C. , Jones Kenneth L. , Oweida Ayman J. , Karam Sana D. , Raben David , Wang Xiao-Jing 
Published: March 2020

AbstractPurpose:SMAD4 loss causes genomic instability and the initiation/progression of head and neck squamous cell carcinoma (HNSCC). Here, we study whether SMAD4 loss sensitizes HNSCCs to olaparib (PARP inhibitor) in combination with radiotherapy (RT).Experimental Design:We analyzed HNSCC The Cancer Genome Atlas data for SMAD4 expression in association with FANC/BRCA family gene expression. Human HNSCC cell lines were screened for sensitivity to olaparib. Isogenic HNSCC cell lines were generated to restore or reduce SMAD4 expression and treated with olaparib, radiation, or the combination. HNSCC pretreatment specimens from a phase I trial investigating olaparib were analyzed.Results:SMAD4 levels correlated with levels of FANC/BRCA genes in HNSCC. HNSCC cell lines with SMAD4 homozygous deletion were sensitive to olaparib. In vivo, olaparib or RT monotherapy reduced tumor volumes in SMAD4-mutant but not SMAD4-positive tumors. Olaparib with RT dual therapy sustained tumor volume reduction in SMAD4-deficient (mutant or knockdown) xenografts, which exhibited increased DNA damage and cell death compared with vehicle-treated tumors. In vitro, olaparib alone or in combination with radiation caused lower clonogenic survival, more DNA damage–associated cell death, and less proliferation in SMAD4-deficient cells than in SMAD4-positive (endogenous SMAD4 or transduced SMAD4) cells. Applicable to clinic, 5 out of 6 SMAD4-negative HNSCCs and 4 out of 8 SMAD4-positive HNSCCs responded to a standard treatment plus olaparib in a phase I clinical trial, and SMAD4 protein levels inversely correlated with DNA damage.Conclusions:SMAD4 levels are causal in determining sensitivity to PARP inhibition in combination with RT in HNSCCs.
Design of transparent microstrip grid array antenna
Authors: Mohd Ali N. I. , Misran N. , F. Mansor M. , F. Jamlos M. 
Published: March 2020

<p>A transparent grid array antenna of 28 GHz frequency is presented. The radiating element of the antenna is made of ITO thin film and printed on a glass as the dielectric substrate. The simulation of the antenna executed by using Computer Simulation Technology (CST) Microwave Studio software demonstrated at 28 GHz operating frequency for 5G band applications. This antenna then compared to the rectangular microstrip patch antenna of the same operating frequency. Structural parameters of the proposed antenna were optimized based on parametric studies done. Grid array antenna gives better performance as it gives 35.7% lower return loss with -43.88 dB, better efficiency and gain with a gain of 7.358 dB, which is more than 40% increases.</p>
Real time robustness test evaluation performance for intelligent fuzzy controller in extraction process
Authors: Mohd Yusoff Z. M. Zakiah , Khirul Ashar Nur Dalila , Muhammad Zuraida , Zainal Abidin Amar Faiz , Razali Noor Fadzilah , Azeehan Azli Shakira , MaArkom A.M. , Bin Hasan Khairul Kamarudin 
Published: March 2020

This paper presents the real time robustness test using intelligent fuzzy based controller in extraction process of essential oil is discussed in this study. Previous finding shows that the quality of the essential oil is affected by the steam temperature that acts as the control variable in this study. The robustness test is applied to the system during running process to show the system is robust to any operation conditions t make sure the controller is able to give a smooth control output response. The dynamic performance of the system are represented by applying standard performance criteria such as rise time Tr, settling time Ts, overshoot <em>%OS</em>, root mean square error (RMSE) and time on recovering load disturbance. Generally, the objectives in designing the controllers have been achieved because all intelligent fuzzy based controllers capable to regulate the desired set point by acting on the change in the output compared with the set point.
Analysis of an energy storage sizing for grid-connected photovoltaic system
Authors: Nazmin Azmi Aimie , Salim Norhafiz , Khamis Aziah 
Published: March 2020

This paper present on the analysis of an energy storage sizing for a small grid-connected PV system. This project is to study the proper sizing of energy storage (battery) in a grid-connected PV system for consumers whom purchase and sell electricity from and to the utility grid. The goal is to minimize the total cost of the operation for a consumer with a PV system with a battery storage system. This is to make sure that minimizing the total annual operating cost while maintaining an efficient system. This study uses typical consumer load consumption, and solar irradiance data throughout a year, while varying the type of battery storage (study lead acid and Lithium ion battery) as an energy storage for a similar system. Since lithium ion is not the main options to be integrated with PV system, this study will then reveal the data in terms of cost on why it is not a popular choice.
A review on sensing-based strategies of interior lighting control system and their performance in commercial buildings
Authors: Rijal Wagiman Khairul , Noor Abdullah Mohd , Yusri Hassan Mohammad , Mohammad Radzi Nur Hanis 
Published: March 2020

<p>Artificial lighting consumed significant amount of electrical energy in commercial buildings. Therefore, intelligent control strategies are widely implemented to reduce the lighting energy consumption. This paper presents comprehensive review of the current sensing-based strategies (i.e. occupancy, daylight and mixed), sensors placement methods (i.e. occupancy and light) and factors affecting the performance of the lighting control strategies. Based on literature survey, the sensors placement methods can be categorized into three approaches: fixed, mathematical equation and optimization. The state-of-the-art of these approaches are discusses in details. It found that, the optimization-based approach capable to find the optimal sensor placement (numbers and positions) effectively. Moreover, the mixed strategy can be produced the highest energy savings up to 95% compared with other strategies. The occupancy pattern and building characteristics are the main factors to contribute higher energy savings of sensing-based strategies in commercial buildings. </p>
Modelling emotion expression through agent oriented methodology
Authors: Zulkifli S.Filzah , Shiang CW , Jali N , Khairuddin M.A. 
Published: March 2020

<span>This paper presents Modelling Emotion Expression through Agent Oriented Methodology. Considering emotions of the intended users in the software engineering can uncover new requirements to improve and more accepted the system. While emotion is paying much attention nowadays, there is lacking systematic way to model the emotion based system. Without the systematic approach, it is hard to debug, design and develop an emotion based system. Since the emotional requirement of people has not being fully investigated, the research outcome propose the emotion modelling as part of the complete set of agent-oriented modelling for virtual character in eLearning system, The contribution of this paper is to introduce agent oriented modelling to systematic model an emotion based solution for an eLearning system and instructional video design. With the emotion model, it can serve as a guide to design, redesign, and discuss the emotion elements among the software development team. This is important for better debugging and project management especially for emotion led system.</span>
Can rational sampling maximise isolation and fix distribution measure of entomopathogenic nematodes?
Authors: Abd-Elgawad Mahfouz M.M. 
Published: March 2020

Summary
Entomopathogenic nematodes (EPN) can infect and kill a wide range of insect pests and are used as safe alternatives to chemical insecticides. Hence, a hypothesis was tested for obtaining EPN with high recovery frequency value and accurate distribution pattern based on combining four factors: favourable sampling method, time and site targeting and use of multiple extraction technique. As the extreme diversity of EPN sampling makes any generalisation from a given case study difficult, this functional sampling was limited to recovering EPN from citrus trees only in Egypt. It could both detect more EPN isolates and allow the application of different indices of dispersion to study their spatial distribution pattern. Therefore, stratified random and systematic sampling from weed-infested soil under tree canopy during the season of abundant insect pests was done, followed by multiple cycles of Galleria-baiting technique. Consequently, the nematodes were recovered from the seven surveyed groves (100%) and from 37 of 60 (61.7%) soil samples. The spatial distribution of these EPN isolates, previously identified as Heterorhabditis indica, was characterised using five dispersion indices, which were mainly a random rather than an over-dispersed distribution.
Healthcare Resource Allocation and Priority-setting. A European Challenge
Authors: Di Costanzo Caterina 
Published: March 2020

Abstract
The right to health, as a right to healthcare, represents the most expensive social right in Europe, significantly affecting the total budget of the Member States, both in universal and insurance healthcare systems. No healthcare system provides unlimited healthcare resources to all its users. The resources available for healthcare are limited compared with demand, and all healthcare systems, regardless of their financing and organisation, employ mechanisms to prioritise finite healthcare resources. The progressive increase in healthcare costs in a context of scarce resources, worsened by the fiscal crisis of the 1990s and economic crises spreading in Europe since 2007, has highlighted the ever more urgent need to address the fundamental issues of resource allocation and priority-setting at both European and national levels. Hence, priority-setting is arguably one of the most important health policy issues of our time at global, European and national levels.
Untold Tales and Occluded Histories
Authors: Krishnamurthy Sarala 
Published: March 2020

Abstract
The Herero Nama Genocide is a painful period in Namibian history and yet it is the period about which several novels have been written in the past ten years. This article examines one of the novels of this period, The Lie of the Land by Jasper Utley, with a view to exploring the ambivalence in its writing. Using witness bearing and the concept of the ‘Other’ in postcolonialism, I investigate the narrator’s language and lay bare the ambiguities in the novel. I trace the path of the eponymous hero from being a witness to the Nama Genocide to an active involvement in the rescue of a Nama woman whom he falls in love with.
Disillusionment and Disappointment
Authors: Loimeier Manfred 
Published: March 2020

Abstract
Both Zimbabwean author NoViolet Bulawayo and South African author Niq Mhlongo encapsulate in novels published by each of them in 2013 what has become of their governments’ promises of freedom and prosperity. In her novel We Need New Names, Bulawayo criticises the poverty, corruption and mismanagement seen under the regime of Robert Mugabe and caricatures the grandiose slogans of ‘Black Power.’ In his novel Way Back Home, Mhlongo reveals how a former anti-apartheid activist in the ANC becomes enmeshed in self-enrichment and nepotism and is pursued by the ghosts of the past. Both Bulawayo and Mhlongo are not content with merely decoding slogans, but identify possible paths to a future with greater self-determination. Disappointment about the unredeemed promises is thus transformed into a sobering résumé and stocktaking that can provide a basis for a new consideration and new definition of social objectives.
‘Why don’t you let me flow in my space?’
Authors: Ellis Hugh 
Published: March 2020

Abstract
The practice of performance or ‘spoken word’ poetry has gained a significant foothold among the youth in urban Namibia in the last two decades. While this poetry has been put to many socio-political uses, one of the main ones has been a protest against patriarchal elements in Namibian society and culture, and an outcry against Namibia’s high rates of gender-based violence. Patriarchal aspects of Namibia’s national culture are often explicitly linked to violence and to the intersectional nature of oppression. Spoken word poetry has also often given LGBT+ women a space to speak out against their oppression and to normalise their existence. This article shows how women performers have used and modified the conventions of poetry and song to get this challenging—in the Namibian context often radical—message across. The paper argues that poetry in this context has the potential to approximate a localised ‘public sphere’ where inclusive discourse can be held around social issues—bearing mind that people are not excluded from this discourse because of arbitrary reasons such as gender or sexuality.
The Textual History of the Ethiopic Old Testament Project (THEOT): Goals and Initial Findings
Authors: Assefa Daniel , Delamarter Steve , Jost Garry , Lee Ralph , Niccum Curt 
Published: March 2020

Abstract
This article offers an introduction to the Textual History of the Ethiopic Old Testament (THEOT) project. This includes a description of the background to THEOT and its primary purpose of mapping the history of the transmission of the Ethiopic Old Testament. The bulk of the article summarizes the project’s preliminary findings, generally, and, in particular, about Ethiopic Psalms, Song of Songs, Deuteronomy, Ruth, Amos, Obadiah, Jonah, and Haggai. Some attention is also given to evidences of contact with the Hebrew text tradition, although the Ethiopic is clearly a daughter version of the LXX.
Initial Evidence for Increased Weather Salience in Autism Spectrum Conditions
Authors: Bolton Matthew J. , Blumberg William G. , Ault Lara K. , Mogil H. Michael , Hanes Stacie H. 
Published: March 2020

AbstractWeather is important to all people, including vulnerable populations (those whose circumstances include cognitive processing, hearing, or vision differences; physical disability; homelessness; and other scenarios and factors). Autism spectrum conditions affect information processing and areas of neurological functioning that potentially inhibit the reception of hazardous weather information and are of particular concern for weather messengers. People on the autism spectrum tend to score highly in tests of systemizing, a psychological process that heavily entails attention to detail and revolves around the creation of logical rules to explain things that occur in the world. This article reports the results of three preliminary studies examining weather salience—psychological attention to weather—and its potential relationships with systemizing in autistic people. Initial findings suggest that enhanced weather salience exists among autistic individuals relative to those without the condition and that this may be related to systemizing. These findings reveal some possible strategies for communicating weather to autistic populations and motivate future work on a conceptual model that blends systemizing and chaos theory to better understand weather salience.
Comparison between a new ultrasound probe with a capacitive micromachined transducer (CMUT) and a traditional one in musculoskeletal pathology
Authors: Draghi Ferdinando , Lomoro Pascal , Bortolotto Chandra , Mastrogirolamo Luca , Calliada Fabrizio 
Published: March 2020

Background The capacitive micromachined ultrasound transducer (CMUT) is a new ultrasound (US) probe manufactured by state-of-the-art cutting-edge semi-conductor micromachined electro-mechanical systems (MEMS) technology. Purpose To demonstrate the peculiar characteristics of each probe and the limitations that should be improved. Material and Methods This study was performed from March to April 2018. The only inclusion criterion was the presence of disease, so all patients with musculoskeletal, skin, and subcutaneous pathology were included. A total of 66 patients entered this study. The exams of each patient, with both probes, were evaluated retrospectively and independently by three radiologists. Panoramicity of the images, the definition of superficial structures (<2 cm of depth), the definition of deep structures (>2 cm), and Doppler signal were assessed. A 5-point scale was used for each parameter. Results A total of 89 pathologies were detected. The mean of score for 4G-CMUT was higher than L64 for the panoramicity of the images and the definition of the deep structures. Instead, the mean score for L64 was higher than for 4G-CMUT in the evaluation of superficial structures and Doppler signal. A statistically significant difference was found ( P < 0.05). Conclusion CMUT is a breakthrough in US technology. It allows the use of a single probe for different US examinations. The musculoskeletal, skin, and subcutaneous US can be evaluated with a piezoelectric linear transducer or CMUT. In the present study, the overall diagnostic performance was similar. Improvements in CMUT will provide even more dynamic and flexible imaging capabilities by a transducer, with a wider bandwidth.
Prospective Assessment of Outcomes After Primary Unipolar, Multisurface, and Bipolar Osteochondral Allograft Transplantations in the Knee: A Comparison of 2 Preservation Methods
Authors: Stannard James P. , Cook James L. 
Published: March 2020

Background: Articular cartilage lesions in the knee remain a challenging clinical problem. Hypothesis: A novel graft preservation method combined with surgical technique and patient management improvements would lead to consistently successful outcomes after osteochondral allograft (OCA) transplantation. Study Design: Cohort study; Level of evidence, 3. Methods: With institutional review board approval and informed consent, patients were prospectively enrolled into a registry to follow outcomes after OCA transplantation. Patients were included when ≥1-year follow-up data were available, including complications and reoperations, patient-reported outcome measures (PROMs), compliance with rehabilitation, revisions, and failures. Results: For patients meeting inclusion criteria (N = 194), mean ± SD age was 37.9 ± 12.2 years and mean BMI was 28.9 ± 5; 38% received unipolar transplants (44% multisurface) and 62% received bipolar transplants. OCAs were preserved by standard tissue bank methods (standard preservation [SP]; 29%) or the novel method (Missouri Osteochondral Preservation System [MOPS]; 71%). Initial success rates were 79% for all cases combined, 60% for SP, and 84% for MOPS. MOPS cases were significantly ( P = .028) more likely to be associated with successful outcomes when compared with SP cases. PROMs improved significantly ( P < .05) for all cohorts through 3 to 4 years of follow-up. Revisions were performed in 19 cases (10%). MOPS grafts were associated with a significantly ( P = .0014) lower revision rate (5%) than SP grafts (21%). Failures occurred in 26 patients (13%), with all undergoing total knee arthroplasty. Bipolar cases were significantly ( P = .008) more likely to be associated with failure. MOPS grafts were associated with a significantly ( P = .048) lower failure rate (11%) than were SP grafts (19%). Noncompliance with the prescribed rehabilitation protocol was significantly ( P = .00008) more likely to be associated with failure. Conclusion: Prospective data for 194 cases revealed that OCA transplantation for unipolar, multisurface, and bipolar cartilage restoration can be associated with consistently successful outcomes. The 5% revision rate, 11% failure rate, 82%-94% survival probability estimates, and continually improving PROMs through postoperative 3 to 4 years underscore major advances in outcomes as compared with previous reports. These encouraging results were realized with the use of a novel graft preservation method; autogenous bone marrow concentrate pretreatment of donor bone; advancements in graft cutting, implantation, and stabilization techniques; and procedure-specific rehabilitation protocols.
Comparison of Fixed-Dose Inhaled Epoprostenol and Inhaled Nitric Oxide for Acute Respiratory Distress Syndrome in Critically Ill Adults
Authors: Buckley Mitchell S. , Agarwal Sumit K. , Garcia-Orr Roxanne , Saggar Rajeev , MacLaren Robert 
Published: March 2020

Purpose: Several reports have demonstrated similar effects on oxygenation between inhaled epoprostenol (iEPO) compared to inhaled nitric oxide (iNO) for acute respiratory distress syndrome (ARDS). Previous studies directly comparing oxygenation and clinical outcomes between iEPO and iNO exclusively in an adult ARDS patient population utilized a weight-based dosing strategy. The purpose of this study was to compare the clinical and economic impact between iNO and fixed-dosed iEPO for ARDS in adult intensive care unit (ICU) patients. Methods: This retrospective cohort study was conducted at a major academic medical center between January 1, 2014, and October 31, 2018. Patients ≥18 years of age with moderate-to-severe ARDS were included. The primary end point was to compare the mean change in partial arterial oxygen pressure to fraction of inspired oxygen (Pao 2: Fio 2) at 4 hours from baseline between iEPO and iNO. Other secondary aims were total acquisition drug costs, in-hospital mortality, ICU and hospital length of stay, and duration of mechanical ventilation. Results: A total of 239 patients were included with 139 (58.2%) and 100 (41.8%) in the iEPO and iNO groups, respectively. The mean change in Pao 2: Fio 2 at 4 hours from baseline in the iEPO and iNO groups were 31.4 ± 54.6 and 32.4 ± 42.7 mm Hg, respectively ( P = .88). The responder rate at 4 hours was similar between iEPO and iNO groups (64.7% and 66.0%, respectively, P = .84). Clinical outcomes including mortality, overall hospital and ICU length of stay, and mechanical ventilation duration were similar between iEPO and iNO groups. Estimated annual cost-savings realized with iEPO was USD1 074 433. Conclusion: Fixed-dose iEPO was comparable to iNO in patients with moderate-to-severe ARDS for oxygenation and ventilation parameters as well as clinical outcomes. Significant cost-savings were realized with iEPO use.