bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinct clinicopathological differences between early gastric cardiac and non-cardiac carcinomas: A single-center retrospective study of 329 radical resection cases
Authors: wang yaohui , Li Xiu Qing , Gao Li Li , Wang Chen Xi , Zhang Yi Fen , Huang Qin 
Published: July 2020

Abstract
Background: Early gastric carcinoma is heterogeneous and can be divided into early gastric cardiac carcinoma (EGCC) and early gastric non-cardiac carcinoma (EGNCC) groups. At present, differences in clinicopathology remains obscure between EGCC and EGNCC fundus-corpus and antrum-angularis-pylorus subgroups, especially between EGCC with and without oesophageal invasion.Methods : In this study, we studied 329 consecutive early gastric carcinoma radical gastrectomies with 70 EGCCs and 259 EGNCCs.Results : Compared to the EGNCC antrum-angularis-pylorus (n=181), but not fundus-corpus (n=78), sub-group, EGCC showed significantly older age, lower prevalence of the grossly depressed pattern, better tumor differentiation, higher percentage of tubular/papillary adenocarcinoma, but lower frequency of mixed poorly cohesive carcinoma with tubular/papillary adenocarcinoma, and absence of lymph node metastasis (LNM) in tumors with invasion up to superficial submucosa (SM1). In contrast, pure poorly cohesive carcinoma was less frequently seen in EGCCs than in EGNCCs, but mixed poorly cohesive carcinoma with tubular/papillary adenocarcinomas was significantly more common in the EGNCC antrum-angularis-pylorus sub-group than in any other group. No significant differences were found between EGCC and EGNCC sub-groups in gender, tumor size, H. pylori infection rate, and lymphovascular/perineural invasion. EGCC with oesophageal invasion (n=22), compared to EGCC without (n=48), showed no significant differences in the H. pylori infection rate and oesophageal columnar, intestinal, or pancreatic metaplasia, except for a higher percentage of the former in size > 2 cm and tubular differentiation. Conclusions : There exist distinct clinicopathologic differences between EGCC and EGNCC sub-groups; EGCC was indeed of gastric origin. Further investigations with larger samples are needed to validate these findings.
Systematic Human Rights Violations, Traumatic Events, Daily Stressors and Mental Health of Rohingya Refugees in Bangladesh
Authors: Riley Andrew , Akther Yasmin , Noor Mohammed , Ali Rahmat , Welton-Mitchell Courtney 
Published: July 2020

Abstract
Background: Almost 900,000 Rohingya refugees currently reside in refugee camps in Southeastern Bangladesh. Prior to fleeing Myanmar, Rohingya experienced years of systematic human rights violations, in addition to other historical and more recent traumatic events such as the burning of their villages and murder of family members, friends and neighbors. Currently, many Rohingya struggle to meet basic needs in refugee camps in Bangladesh and face mental health-related concerns that appear linked to such challenges. The purpose of this study is to describe systematic human rights violations, traumatic events, daily stressors, and mental health symptoms and to examine relationships between these factors. Methods: Cross-sectional data was collected from a representative sample of 495 Rohingya refugee adults residing in camps in Bangladesh in July and August of 2018. Results: Respondents reported high levels of systematic human rights violations in Myanmar, including restrictions related to expressing thoughts, meeting in groups, travel, religious practices, education, marriage, childbirth, healthcare, and more. Events experienced in Myanmar included exposure to gunfire (99%), destruction of their homes (93%), witnessing dead bodies (92%), torture (56%), forced labor (49%), sexual assault (33%), and other events. More than half (61%) of participants endorsed mental health symptom levels typically indicative of PTSD, and more than two thirds (84%) endorsed levels indicative of emotional distress (symptoms of anxiety and depression). Historic systematic human rights violations, traumatic events, and daily stressors were associated with symptoms of posttraumatic stress, as well as depression and anxiety. Respondents reported numerous stressors associated with current life in the camps in Bangladesh as well as previous stressors, such as harassment, encountered in Myanmar. Conclusions: Findings underscore the impact of systematic human rights violations, targeted violence, and daily stressors on the mental health of Rohingya in Bangladesh. Those working with Rohingya should consider the role of such factors in contributing to poor mental health. This research has the potential to inform interventions targeting such elements. Future research should examine the relationships between mental health and human rights violations over time.
Investigation on microstructure and mechanical properties of short-carbon-fiber/Ti3SiC2 composites
Authors: He Guangqi , Guo Rongxiu , Li Meishuan , Yang Yang , Wang Linshan , Qian Yuhai , Zuo Jun , Xu Jingjun , Liu Changsheng 
Published: July 2020

Abstract
In this paper, short-carbon-fibers (Csf) reinforced Ti3SiC2 matrix composites (Csf/Ti3SiC2, the Csf content was 0, 2, 5 and 10 vol.%) were fabricated by spark-plasma-sintering (SPS) using Ti3SiC2 powders and Csf as starting materials at 1300 oC. The effects of Csf addition on the phase compositions, microstructures and mechanical properties (including hardness, flexural strength and fracture toughness) of Csf/Ti3SiC2 composites were investigated. The Csf, with a bi-layered transition layers, i.e. TiC and SiC layer, were homogeneously distributed in the as-prepared Csf/Ti3SiC2 composites. With the increase of Csf content, the fracture toughness of Csf/Ti3SiC2 composites increased, but the flexural strength decreased, while the Vickers hardness decreased initially then increased steadily when the Csf content was higher than 2 vol.%. These changed performances could be attributed to the introduction of Csf and the formation of much stronger interfacial phases.
Tensor Recovery from Noisy and Multi-Level Quantized Measurements
Authors: Wang Ren , Wang Meng , Xiong Jinjun 
Published: July 2020

Abstract
Higher-order tensors can represent scores in a rating system, frames in a video, and images of the same subject. In practice, the measurements are often highly quantized due to the sampling strategies or the quality of devices. Existing works on tensor recovery have focused on data losses and random noises. Only a few works consider tensor recovery from quantized measurements but are restricted to binary measurements. This paper, for the first time, addresses the problem of tensor recovery from multi-level quantized measurements by leveraging the low CANDECOMP/PARAFAC (CP) rank property. We study the recovery of both general low-rank tensors and tensors that have tensor singular value decomposition (TSVD) by solving nonconvex optimization problems. We provide the theoretical upper bounds of the recovery error, which diminish to zero when the sizes of dimensions increase to infinity. We further characterize the fundamental limit of any recovery algorithm and show that our recovery error is nearly order-wise optimal. A tensor-based alternating proximal gradient descent algorithm with a convergence guarantee and a TSVD based projected gradient descent algorithm are proposed to solve the nonconvex problems. Our recovery methods can also handle data losses and do not necessarily need the information of the quantization rule. The methods are validated on synthetic data, image datasets, and music recommender datasets.
Immediate Effects of First-line Thrombectomy Devices for Intracranial Atherosclerosis-Related Occlusion: Stent Retriever versus Contact Aspiration
Authors: Yoo Joonsang , Lee Seong-Joon , Hong Jeong-Ho , Kim Yong-Won , Hong Ji Man , Kim Chang-Hyun , Kang Dong-Hun , Choi Jin Wook , Kim Yong-Sun , Sohn Sung-Il , Hwang Yang-Ha , Lee Jin Soo 
Published: July 2020

Abstract
Background: Although stent retriever (SR) is recommended as a frontline device of endovascular treatment (EVT) for embolic large artery occlusion causing acute ischemic stroke, contact aspiration (CA) device showed similar efficacy in the recent trials. However, the efficacy of the both devices as first-line therapy for intracranial atherosclerotic stenosis (ICAS)-related large vessel occlusion has not yet been established. Therefore, we compared the immediate effects and final outcomes of SR and CA as first-line devices for treating ICAS-related occlusions.Methods: We retrospectively analyzed the data of patients who underwent EVT for acute ischemic stroke from the registry of three Korean hospitals. Patients with ICAS-related occlusion who were treated within 24 hours of onset of the symptoms were included. We investigated immediate reperfusion performance, immediate safety outcomes, and 3-month clinical outcomes for the two first-line devices.Results: Of the 720 registered patients, 111 were eligible for this study. Forty-nine patients (44.1%) used SR and 62 (55.9%) used CA as the first-line device. Achieving successful reperfusion immediately after first-line thrombectomy was more frequent in the SR group than that in the CA group (77.6% vs. 43.5%, p = 0.001), with fewer additional rescue treatments (12.2% vs. 59.7%, p < 0.001). The incidence of iatrogenic dissection or rupture was lower in the SR group than that in the CA group (8.2% vs. 29.0%, p = 0.012). After additional rescue treatments, however, the final successful reperfusion rate did not differ between the two groups (SR 87.8% vs. CA 77.4%, p = 0.247), and there was no significant difference in the 3-month good outcomes (modified Rankin Scale, p = 0.524).Conclusions: First-line SR thrombectomy showed higher immediate reperfusion and less vessel injury for ICAS-related occlusions than CA. However, there was no significant difference in the final reperfusion status or 3-month outcomes from additional rescue treatments.
A novel STS mutation and an Xp22.3 microdeletion from one Chinese family with X-linked ichthyosis
Authors: Huang Yufeng , Luo Sukun , Zhao Peiwei , Tan Li , Fu Guili , He Xuelian 
Published: July 2020

Abstract
Background X-linked ichthyosis (XLI, OMIM# 308100) is a relatively common type of skin disorder, characterized by widespread, dark brown, polygonal scales and generalized dryness. Most patients (90%) are contributed to genomic deletion of the entire STS (steroid sulfatase) gene encoding steroid sulfatase, with the remaining cases being caused by point mutations or partial deletions. The patient carrying genomic deletion comprising the entire STS gene and adjacent genes often manifests neurological symptoms. Methods Herein, we reported a large four-generation Chinese family with 5 individuals with XLI with/ without mental delay. Genetic analysis was conducted by whole exome sequencing and confirmed by Sanger sequencing and quantitative Real-time PCR. Results These patients present generalized dryness and scaling of the skin with dark scales of the skin on trunk, and limbs. Two pathogenic variants, a novel STS mutation (c.1532A > G, p.E511G, NM_000351) and a ~ 2 Mb genomic microdeletion at Xp22.3 (6,451,785-8,434,424) embracing entire STS gene were identified in this family. In addition, an individual with Xp22.3 deletion has mental delay. Conclusion Our study expands the genetic profile of the STS gene in XLI patients and highlights the clinical application of exome sequencing.
Histological study of sheep skin transformation during the recreation of historical parchment manufacture
Authors: Fourneau Marc , Canon Caroline , Vlaender Daniel Van , Collins Matthew J. , Fiddyment Sarah , Poumay Yves , Deparis Olivier 
Published: July 2020

Abstract
We report a simple histological study on skin biopsies from young domestic sheep following each step in transformation from skin to parchment production. During the recreation of historical parchment manufacture, histological analyses were conducted; before and after lime treatment, hair removal, and stretching. Sections were fixed and stained using a variety of histological stains to identify the presence of different molecular classes and the fibrous proteins, collagen and elastin. The results reveal surprisingly few histological changes in most steps in the production process. However, very visible changes in the supramolecular ordering of skin macromolecules (elastin, collagen) occur during the final stage of parchment production when stretched on the frame. Collagen fibres and hair follicles were all strongly re-oriented in the direction of strain. Surprisingly despite the thinness of the lambskin and the exhaustive treatment in lime, not all fats were saponified and even in the final product Oil Red O stained fat bodies were detectable on the hair side of the skin. We believe this study will help compensate for the lack of sources on microscopic changes in parchment during the recreation of its historical manufacture.
High-entropy (Nd0.2Sm0.2Eu0.2Y0.2Yb0.2)4Al2O9 with good high temperature stability, low thermal conductivity and anisotropic thermal expansivity
Authors: Zhao Zifan , Xiang Huimin , Chen Heng , Dai Fu-zhi , Wang Xiaohui , Peng Zhijian , Zhou Yanchun 
Published: July 2020

Abstract
The critical requirements for the environmental barrier coating (EBC) materials of silicon-based ceramic matrix composites (CMCs) including good tolerance to harsh environments, thermal expansion match with the interlayer mullite, good high-temperature phase stability and low thermal conductivity. Cuspidine-structured rare-earth aluminates RE4Al2O9 have been considered as candidates of EBCs for their superior mechanical and thermal properties, but the phase transition at high temperatures is a notable drawback of these materials. To suppress the phase transition and improve the phase stability, a novel cuspidine-structured rare-earth aluminate solid solution (Nd0.2Sm0.2Eu0.2Y0.2Yb0.2)4Al2O9 was designed and successfully synthesized inspired by entropy stabilization effect of high entropy ceramics. The as-synthesized (Nd0.2Sm0.2Eu0.2Y0.2Yb0.2)4Al2O9 exhibits close thermal expansion coefficient (6.96×10-6 /K at 300-1473 K) to that of mullite, good phase stability from 300 K to 1473 K, and low thermal conductivity (1.50 W·m-1·K-1 at room temperature). In addition, strong anisotropic thermal expansion has been observed compared to Y4Al2O9 and Yb4Al2O9. The mechanism for low thermal conductivity is attributed to the lattice distortion and mass difference of the constituent atoms while the anisotropic thermal expansion is due to the anisotropic chemical bonding enhanced by the large size rare earth cations.
N-Terminal Pro-B-Type Natriuretic Peptide as a Prognostic Indicator for 30-Day Mortality Following Out-of-Hospital Cardiac Arrest: A prospective observational study.
Authors: Aarsetøy Reidun , Omland Torbjørn , Røsjø Helge , Strand Heidi , Lindner Thomas Werner , Aarsetøy Hildegunn , Staines Harold , Nilsen Dennis Winston Trygve 
Published: July 2020

Abstract
Background: Early risk stratification applying cardiac biomarkers may prove useful in sudden cardiac arrest patients. We investigated the prognostic utility of early-on levels of high sensitivity cardiac troponin-T (hs-cTnT), copeptin and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with out-of-hospital cardiac arrest (OHCA).Methods: We conducted a prospective observational unicenter study, including patients with OHCA of assumed cardiac origin from the southwestern part of Norway from 2007 until 2010. Blood samples for later measurements were drawn during cardiopulmonary resuscitation or at hospital admission.Results: A total of 114 patients were included, 37 patients with asystole and 77 patients with VF as first recorded heart rhythm. Forty-four patients (38.6 %) survived 30-day follow-up. Neither hs-cTnT (p = 0.49), nor copeptin (p = 0.39) differed between non-survivors and survivors, whereas NT-proBNP was higher in non-survivors (p < 0.001) and significantly associated with 30-days all-cause mortality in univariate analysis, with a hazard ratio (HR) for patients in the highest compared to the lowest quartile of 4.6 (95% confidence interval (CI), 2.1 – 10.1), p < 0.001. This association was no longer significant in multivariable analysis applying continuous values, [HR 0.96, (95% CI, 0.64 - 1.43), p = 0.84]. Similar results were obtained by dividing the population by survival at hospital admission, excluding non-ROSC patients on-scene [HR 0.93 (95% CI, 0.50 - 1.73), P = 0.83]. We also noted that NT-proBNP was significantly higher in asystole- as compared to VF-patients, p < 0.001.Conclusions: Early-on levels of hs-cTnT, copeptin and NT-proBNP did not provide independent prognostic information following OHCA. Prediction was unaffected by excluding on-scene non-ROSC patients in the multivariable analysis. Clinical Trial Registration: ClinicalTrials. gov, NCT02886273.
Predictive accuracy of biomarkers for survival among cardiac arrest patients with hypothermia: A prospective observational cohort study in Japan
Authors: Okada Yohei , Kiguchi Takeyuki , Irisawa Taro , Yoshiya Kazuhisa , Yamada Tomoki , Hayakawa Koichi , Noguchi Kazuo , Nishimura Tetsuro , Ishibe Takuya , Yagi Yoshiki , Kishimoto Masafumi , Shintani Hiroshi , Hayashi Yasuyuki , Sogabe Taku , Morooka Takaya , Sakamoto Haruko , Suzuki Keitaro , Nakamura Fumiko , Nishioka Norihiro , Matsuyama Tasuku , Matsui Satoshi , Shimazu Takeshi , Koike Kaoru , Kawamura Takashi , Kitamura Tetsuhisa , Iwami Taku 
Published: July 2020

Abstract
Background: There is little limited information on the predictive accuracy of commonly used predictors, such as lactate, pH or serum potassium for the survival among out-of-hospital cardiac arrest (OHCA) patients with hypothermia. This study aimed to identify the predictive accuracy of these biomarkers for survival among OHCA patients with hypothermia.Methods: In this retrospective study, we analyzed the data from a multicenter, prospective nationwide registry among OHCA patients transported to emergency departments in Japan (the JAAM-OHCA Registry). We included all adult (≥18 years) OHCA patients with hypothermia (≤32.0°C) who were registered from June 2014 to December 2017 and whose blood test results on hospital arrival were recorded. We calculated the predictive accuracy of pH, lactate, and potassium for 1-month survival.Results: Of the 34,754 patients in the JAAM-OHCA database, we included 754 patients from 66 hospitals. The 1-month survival was 5.8% (44/754). The areas under the curve of the predictors and 95% confidence interval were as follows: pH 0.829 [0.767–0.877] and lactate 0.843 [0.793–0.882]. On setting the cutoff points of 6.9 in pH and 120 mg/dL (13.3 mmol/L) in lactate, the predictors had a high sensitivity (lactate: 0.91; pH 0.91) and a low negative likelihood ratio (lactate: 0.14; pH 0.13), which are suitable to exclude survival to 1 month. Furthermore, in additional analysis that included only the patients with potassium values available, a cutoff point of 7.0 (mmol/L) for serum potassium had high sensitivity (0.96) and a low negative likelihood ratio (0.09).Conclusion: This study indicated the predictive accuracy of serum lactate, pH, and potassium for 1-month survival among adult OHCA patients with hypothermia. These biomarkers may help define a more appropriate resuscitation strategy. pH 6.9 and lactate 120 mg/dL can predictively rule out 1-month survival.
Detection of subclinical skin manifestation in patients with psoriasis and psoriatic arthritis by fluorescence optical imaging
Authors: Schmidt Angelique , Glimm Anne-Marie , Haugen Ida Kristin , Hoff Paula , Schmittat Gabriela , Burmester Gerd Ruediger , Klotsche Jens , Ohrndorf Sarah 
Published: July 2020

Abstract
Objectives: To investigate the frequency of subclinical skin inflammation in both hands by fluorescence optical imaging (FOI) in patients with psoriasis/psoriatic arthritis (Pso/PsA) vs. rheumatoid arthritis (RA) and healthy individuals, and to correlate these findings with cardiovascular (CV) risk factors.Patients and Methods: The FOI scans were analyzed retrospectively to detect clinically invisible skin enhancement (0-3 scale) in both hands without relationship to underlying joints or blood vessels. We further characterized the FOI patterns and sorted the scans into groups based on the assumed diagnosis (Pso/PsA, RA and healthy controls), which was compared with the physician’s diagnosis. Furthermore, the associations between CV risk factors and imaging findings were investigated by regression analyses.Results: We included FOI scans of patients with Pso/PsA (n=80), RA (n=78) and healthy controls (n=25). Subclinical skin enhancement on the back of their hands was more common in Pso/PsA (72.5%) than in RA patients (20.5%) and healthy individuals (28.0%) (p<0.001). Based on the FOI pattern, the majority of patients with Pso/PsA (72.5%), RA (76.9%) and healthy controls (68.0%) were classified correctly using the physician-based diagnosis as reference (overall agreement of 74%, kappa=0.57). No CV risk factors except body weight (kg) was associated with subclinical skin enhancement (OR 1.04, 95% CI 1.02-1.06; p<0.001). Conclusion: Subclinical subdermal skin inflammation was common in Pso/PsA patients using FOI. Based on the FOI pattern, most patients with Pso/PsA and were classified with the correct diagnosis. We demonstrated an important influence of the body weight on our FOI results. FOI may be a helpful novel tool to study microcirculation in rheumatic diseases with skin involvement.
Risk factors for the critical illness in SARS-CoV-2 infection: a multicenter retrospective cohort study
Authors: Cheng Sijing , Wu Dingfeng , Li Jie , Zou Yifeng , Wan Yunle , Shen Lihan , Zhu Lixin , Shi Mang , Hou Linlin , Xu Tao , Jiao Na , Li Yichen , Huang Yibo , Tang Zhipeng , Xu Mingwei , Jiang Shusong , Li Maokun , Yan Guangjun , Lan Ping , Zhu Ruixin 
Published: July 2020

Abstract
Background: Prior studies reported that 5~32% COVID-19 patients were critically ill, a situation that poses great challenge for the management of the patients and ICU resources. We aim to identify independent risk factors to serve as prediction markers for critical illness of SARS-CoV-2 infection. Methods : Fifty-two critical and 200 non-critical SARS-CoV-2 nucleic acid positive patients hospitalized in 15 hospitals outside Wuhan from January 19 to March 6, 2020 were enrolled in this study. Multivariable logistic regression and LASSO logistic regression were performed to identify independent risk factors for critical illness.Results: Age older than 60 years, dyspnea, respiratory rate > 24 breaths per min, leukocytosis >9.5 X109/L, neutrophilia >6.3 X109/L, lymphopenia <1.1 X109/L, neutrophil-to-lymphocyte ratio >3.53, fibrinogen >4g/L, d-dimer >0.55 µg/mL, blood urea nitrogen >7.1 mM, elevated aspartate transaminase, elevated alanine aminotransferase, total bilirubin >21 µM, and Sequential Organ Failure Assessment (SOFA) score ≥2 were identified as risk factors for critical illness. LASSO logistic regression identified the best combination of risk factors as SOFA score, age, dyspnea, and leukocytosis. The Area Under the Receiver-Operator Curve values for the risk factors in predicting critical illness were 0.921 for SOFA score, 0.776 for age, 0.764 for dyspnea, 0.658 for leukocytosis, and 0.960 for the combination of the four risk factors.Conclusions: Our findings advocate the use of risk factors SOFA score ≥2, age >60, dyspnea and leukocytosis >9.5 X109/L on admission, alone or in combination, to determine the optimal management of the patients and health care resources.