bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histological comparison of formocresol, enamel matrix derivative and turmeric extract as pulpotomy agents in primary teeth
Authors: Bashir Nazia , Naz Shazia , Dastgeer Rabia , Khatoon Samina , Hussain Md. Asdaq 
Published: December 2024

Abstract

Background
This study aimed to compare and histologically evaluate the pulpal inflammatory response and dentin bridge formation using Formocresol (FC), Enamel Matrix Derivative (EMD), and Turmeric Extract (TE) as pulpotomy agents in primary teeth.
Methods
Eighty-one patients, aged 8–10 years, requiring both serial extraction and pulpotomy of primary molars were enrolled in this study. One symptomless carious molar tooth from each patient was selected. The participants were divided into three equal groups (n = 27 each) based on the time planned for serial extraction: 1 week, 2 weeks, and 6 months. Each group was subdivided into three sub-groups (n = 9) according to the pulpotomy agent used (FC, EMD, or TE). Histological evaluations were performed post-extraction to assess pulpal inflammatory response and dentin bridge formation. Statistical analysis was carried out using Fisher’s exact test, with a significance threshold set at p < 0.05.
Results
A statistically significant difference was observed among the three materials regarding pulpal inflammatory response and dentin bridge formation. At 1 week, the FC and EMD groups had moderate inflammation in 88.9% and 77.8% of cases, respectively, while the TE group showed mild inflammation in 55.6% of cases. After 2 weeks, 77.8% of the TE group displayed mild inflammation, 66.7% of the EMD group showed moderate inflammation, and 22.2% of the FC group exhibited severe inflammatory response. By 6 months, 88.9% of the TE group had mild inflammation, while 44.4% of the EMD group showed moderate and 33.3% of the FC group demonstrated severe inflammation. Regarding dentin bridge formation after 6 months, 77.8% of the EMD group exhibited over 75% bridge formation whereas 88.9% of the FC group showed no bridge formation. The TE group showed moderate development with 66.7% showing less than 25% bridge formation.
Conclusion
TE and EMD demonstrated promising results in this study. Compared to FC, TE showed potential in reducing pulpal inflammation, while EMD was the most effective at promoting dentin bridge formation. However, further studies with extended follow-up are needed to determine the safe clinical indications for these alternative pulpotomy agents in primary teeth.
Effects of geographical and soil factors on soil arsenic levels in a typical arsenic-contaminated paddy field area
Authors: Zhang Renjie , Jiang Liheng , Dong Tianhao , Xie Yunhe , Pan Shufang , Liu Saihua , Huang Rui , Ji Xionghui , Xue Tao 
Published: December 2024

Abstract

Heavy metal pollution in agricultural land has emerged as a contemporary environmental issue of prominent concern. The concentration of heavy metals in soil is influenced not only by inherent soil properties but also by geographical factors. Moreover, the identification of its influencing factors is challenging because of the intricate interactive effects among them. Previous studies primarily focused on single-factor identification and spatial distribution characterization, neglecting the characteristics and spatial features of soil heavy metal concentration under the interactive effects of geographical factors and soil properties. This study assessed the influence of geographical factors, soil properties, and their interactive effects on the spatial distribution of soil arsenic (As), in a typical arsenic-contaminated paddy field area by employing machine learning, analysis of variance, and spatial analysis methods. The findings show that the primary factors influencing the distribution of soil As are elevation, roads, rivers, soil pH, and cation exchange capacity (CEC). Moreover, the interactive effect between elevation and soil CEC had a significant effect on soil As, exhibiting non-linear and spatially homogeneous characteristics. The interactive effect between rivers and both soil pH and soil CEC exhibited non-linear and spatially heterogeneous effects on soil As. Additionally, the interactive effect between roads and soil pH affected soil As, with non-linear and spatially homogeneous characteristics. By identifying the main influencing factors of As in paddy soil, this study further explores the variation characteristics of soil As concentration under the interactive effects of geographical factors and soil properties. These insights can serve as a valuable reference for the precise prevention of As pollution in paddy field area.
Biomarkers related to interferon-γ pathway in myocardial ischemia-reperfusion injury and the potential molecular mechanisms
Authors: Jia Fang , Jiang Wei , Zhang Yan , Zhang Lisha , Han Tuo , Liu Danmeng , Xue Jiahong , Deng Fuxue 
Published: December 2024

Abstract

Background
Although reperfusion therapy can reduce the mortality of myocardial infarction, it results in myocardial ischemia-reperfusion injury (MIRI). The molecular mechanism by which the interferon-γ pathway affects MIRI is unclear, so we addressed this problem by mining transcriptome and single-cell sequencing data.
Methods
The GSE160516 and GSE83472 datasets, single cell RNA sequencing (scRNA-seq) data of GSE227088 dataset and 182 interferon-γ pathway related genes (IRGs) were retrieved and incorporated into this study. The differentially expressed genes (DEGs) between MIRI and control samples were searched, the candidate genes were obtained by intersecting DEGs with IRGs. The protein-protein interaction (PPI) analysis was utilized for selecting key genes from candidate genes. Moreover, key genes with significant expression and consistent trend in GSE160516 and GSE83472 datasets were selected as biomarkers. The biological functions and regulatory mechanism of biomarkers were investigated by enrichment analysis and predicting the upstream molecules targeting them. Ulteriorly, cell clusters were identified via unsupervised cluster analysis and merged into different cell types by cell annotation. Cell types in which biomarkers observably and differentially expressed were selected as crucial cell types. Finally, cell communication and pseudo-time analysis were implemented based on crucial cell types.
Results
Totally 34 candidate genes were searched by overlapping 1,930 DEGs with 182 IRGs. Nine key genes were singled out from candidate genes, of which Myd88 and Trp53 were significantly upregulated in the MIRI samples of GSE160516 and GSE83472 datasets, so they were identified as biomarkers. Besides, they participated in pathways such as ribosome, spliceosome and cell cycle. Myd88 might be simultaneously regulated by mmu-miR-361-3p and mmu-miR-421-3p, and Trp53 could be regulated by Abl1 and Tead2. Totally 25 cell clusters were merged into six cell types, of which three crucial cell types (cardiomyocyte, fibroblast and macrophage) could interact with each other through receptor-ligand. Pseudo-time analysis revealed states 1, 2 and 5 of macrophages might be associated with MIRI.
Conclusion
Two biomarkers (Myd88 and Trp53) related to IRGs in MIRI were mined, providing a reference for elucidating the mechanism of interferon-γ pathway on MIRI.
Optimizing Internal Logistics in Manufacturing Facilities: Analyzing Alternative Transportation Routes for Cost-Effective and Flexible Solutions
Authors: Coşkun Şengül 
Published: December 2024

Abstract

This study aims to optimize internal logistics processes in manufacturing facilities by analyzing alternative transportation routes and providing optimal solutions. Challenges such as increasing product diversity, complex supply chains, and uncertain demand structures have made the management of logistics processes increasingly critical. By employing vehicle routing methods like Dijkstra’s and k-shortest path algorithms, the study determines optimal transportation routes between facility locations, considering competitive priorities such as cost, quality, delivery speed, and flexibility. In this research, data related to internal logistics processes were analyzed, and a distance matrix was created using the savings algorithm. Based on this matrix, optimal routes were calculated using the k-shortest path algorithm. As part of the application, suitable routes were identified for materials that need to be transported between storage depots, production, and assembly areas within a manufacturing facility. The developed method minimized transportation costs and enhanced flexibility in internal transportation processes. The results demonstrated the effectiveness of collaborative transportation strategies and validated the applicability of the proposed approach through alternative scenario analyses. The study presents a model that serves as a guide not only for the current facility but also for different industries with similar internal logistics processes. It is anticipated that the research will make significant contributions to customer-focused, cost-effective, and flexible logistics management strategies for businesses.
ПРОБЛЕМА ГЛОБАЛЬНОГО НЕРАВЕНСТВА В ТЕОРИЯХ РЕВОЛЮЦИЙ (КРАТКИЙ ЭКСКУРС)
Authors: Демиденко С.В. , Маргулис С.Б. 
Published: December 2024

Статья посвящена анализу подходов к исследованию фактора неравенства в революционных теориях конца XIX – начала XXI вв. С крушением Советского Союза и утратой марксистской парадигмой статуса единственно верной в отечественной науке развернулась дискуссия относительно предпосылок и причин возникновения социальных волнений и революционных взрывов. Неравенству, при этом, не уделялось должного внимания. Вопрос рассматривался либо в разрезе экономических проблем, либо с точки зрения социальных диспропорций. Феномен неравенства имеет весьма сложную природу, соответственно, велика и его роль с точки зрения воздействия на возникновение явлений деструктивных, приводящих к демонтажу текущего социально-политического порядка. В этой связи важным представляется сделать срез научных подходов, чтобы опередить уровень изученности темы и выявить направления для дальнейших исследований.
The article is devoted to the analysis of approaches to the study of the inequality factor in the revolutionary theories of the late XIX – early XXI c. With the collapse of the USSR and loss of the status of the only true Marxist paradigm in Russian science, a discussion unfolded regarding the prerequisites and causes of social unrest and revolutionary explosions, at the same time, in Western science it did not stop for a day. Inequality, as practice shows, was not given due attention. The issue was considered either in the context of economic problems or from the point of view of social imbalances. The phenomenon of inequality has a very complex nature, accordingly, its role is also great in terms of influencing the emergence of destructive phenomena leading to the dismantling of the current socio-political order. In this regard, it is important to make a cross-section of scientific approaches in order to get ahead of the level of knowledge of the topic and identify areas for further research.
Российские ученые-эмигранты и Карлов университет: пути и модели интеграции (1920–1930-е гг.)
Authors: Ковалев М.В. 
Published: December 2024

Статья посвящена анализу путей и моделей взаимодействия русских ученых-эмигрантов с Карловым университетом в 1920–1930-е гг. На основе архивных документов и на конкретных примерах были установлены обстоятельства приглашения эмигрантов на преподавательские должности, обрисованы условия их научно-педагогической работы. Было выявлено, что проблемы трудоустройства зачастую были связаны не с боязнью конкуренции со стороны местных ученых, но были вызваны ограниченностью штатного расписания и бюджета, отсутствием у русских эмигрантов чехословацкого гражданства. Кроме того, в Карловом университете отсутствовала потребность в большом количестве иностранных специалистов, тем более в тех областях, где могли успешно работать местные кадры. Сделан вывод, что чехословацкая образовательная среда впитывала русских ученых гораздо хуже болгарской или югославской. Было продемонстрировано существование различных моделей интеграции русских ученых в Карлов университет. Важную роль в приглашении на работу и трудовом закреплении зачастую играли влиятельные гаранты и патроны из числа местных профессоров. Наибольшие шансы на профессиональную интеграцию получали те ученые, кто сумел приспособить свои научно-педагогические практики к потребностям и запросам местной среды.
In this article the ways and models of interaction between Russian émigré scientists and Charles University in the 1920s and 1930s were analysed. On the basis of archival documents, the circumstances of inviting of émigré scientists to university positions were established, and the conditions of their scientific and pedagogical work were outlined. It was found that employment problems were often not related to the fear of competition from local scientists, but were caused by the limited staffing and budget, and the lack of Czechoslovak citizenship among Russian emigrants. In addition, at Charles University there was no need for a large number of foreign specialists, especially in those areas where local scientists could work successfully. The example of the Charles university shows that the Czechoslovak educational environment absorbed Russian scientists much worse than the Bulgarian or Yugoslav ones. There were various models of integration of Russian scientists at Charles University. However, influential guarantors and patrons from among local professors often played an important role in inviting them to work and securing their employment. The greatest chances for professional integration were received by those scientists who were able to adapt their scientific and pedagogical practices to the needs and demands of the local environment.
КРЕСТЬЯНСКАЯ СЕМЬЯ КАК ПОЛЕ «БИТВЫ ПОКОЛЕНИЙ» ВО ВТОРОЙ ПОЛОВИНЕ 1920-х ГОДОВ
Authors: Вязинкин А.Ю. , Слезин А.А. 
Published: December 2024

Крестьянская семья позднего нэпа рассматривается в статье как объект деятельности коммунистической молодёжи по преобразованию быта и против религии с позиций «поколенческой истории». Основное внимание уделено реакции на инновации поколения «детей революции» (их детство пришлось на послереволюционные годы) представителей крестьянского поколения «революционного перелома» (родившихся на рубеже веков). По мнению авторов, деятельность комсомола хотя и не разрушила патриархальную семью в российской деревне полностью, активно способствовала как её эволюции, так и усилению конфликта поколений. Выявлены связанные с деятельностью комсомола причины его обострения, перерастания в межпоколен-ческий разлом. Авторы рассматривают его как одну из недостаточно изученных сторон раскола деревни на антагонистические лагеря, используемого властью в це-лях ускорения социалистической модернизации.
The paper considers the peasant family of the late NEP as an object of communist youth activity aimed at life transformation and directed against religion from the standpoint of "generational history". The main attention is paid to the reaction to the innovations of the "children of the revolution" generation (their childhood fell in the post-revolutionary years), as well as representatives of the peasant generation of the "revolutionary turning point" (born at the turn of the century). According to the author, the activities of the Komsomol, although they did not completely destroy the patriarchal family in the Russian village, actively contributed both to its evolution and to the intensification of the generational conflict. The article reveals the causes of aggravation and development into the intergenerational rupture, related to the activities of the Komsomol. The author considers it as one of the insufficiently studied aspects of the village split into antagonistic camps, used by the authorities in order to accelerate socialist modernization.
«СВЯЗАННЫЕ ЦАРИ» – ВО ИМЯ ПОЛЬСКОЙ КОНСТИТУЦИИ ИЛИ РОССИЙСКОЙ ИМПЕРИИ?
Authors: Исэров А.А. 
Published: December 2024

В статье разбирается сюжет, впервые упомянутый в литературе М. С. Альперовичем. 13 (2) февраля 1787 г. в Киеве польский граф Игнаций Потоцкий (1750–1809) на званом обеде сказал бывшему полковнику испанской армии, венесуэльцу Франсиско де Миранде (1750–1816), что лучшим памятником Рима показалось ему изображение царей со связанными руками (Reyes ligados pr. las manos). Эта фраза дошла до Г. А. Потёмкина, короля Станислава Августа и его окружения и получила республиканскую трактовку, которая хорошо вписывается в историю жизни собеседников: Игнаций Потоцкий станет соавтором польской Конституции 3 мая 1791 г., в 1792 г. будет исполнять обязанности военного министра, во время восстания Тадеуша Костюшко 1794 г. будет министром иностранных дел; Франсиско де Миранда с 1783 г. готовил революцию в Испанской Америке и возглавит независимую Венесуэлу в 1812 г. В статье впервые определены «связанные цари» – статуи побеждённых варварских правителей (с 1720 г. в Palazzo dei Conservatori). С середины XVI до середины XIX вв. «связанные цари» выставлялись по обе стороны от женской статуи Цереры, переделанной в образ побеждающего, триумфального Рима (Roma victrix, Roma triumphans), – композиция символизировала победу Вечного города. Выдвинута гипотеза о «двойном» смысле слов Игнация Потоцкого: и политическая декларация радикального Просвещения, и скрытый панегирик Екатерине II.
The article deals with a story first mentioned in historiography by Moisei Alperovich. On February 13 (2), 1787, the Polish Count Ignacy Potocki (1750–1809) at a dinner party in Kiev told a former colonel of the Spanish army, the Venezuelan Francisco de Miranda (1750–1816) that the best monument of Rome seemed to him the image of kings with their hands bound (Reyes ligados pr. las manos). This phrase reached Grigory Potemkin, King Stanislaus Augustus and his entourage and received a republican interpretation which fits well with the life story of the interlocutors: Ignacy Potocki would become a co-author of the Polish Constitution of May 3, 1791, in 1792 would serve as an acting War Minister, and during the Tadeusz Kosciuszko Uprising of 1794 would become the Minister of Foreign Affairs; from 1783 Francisco de Miranda was preparing a revolution in Spanish America, and in 1812 he would lead independent Venezuela. The article for the first time attributes the “kings bound” as statues of defeated barbarian rulers (from 1720 in the Palazzo dei Conservatori). From the mid-sixteenth to the mid-nineteenth centuries these “kings bound” were exhibited on both sides of the female statue of Ceres remade as an image of victorious, triumphant Rome (Roma victrix, Roma triumphans) symbolizing the victory of the Eternal City. My hypothesis is that Ignacy Potocki implied a “double” meaning: both a political declaration of the radical Enlightenment and a hidden panegyric to Catherine II.
ТЕКСТЫ И СМЫСЛЫ ПЕРВОЙ МИРОВОЙ
Authors: Ландина Л.В. 
Published: December 2024

В статье рецензируется книга И. Р. Чикаловой «[Не]забытая война: Первая мировая война в документах, публицистике, воспоминаниях и исследованиях современников (1914–1941)», 2-е изд., доп. и перераб. (Минск: Беларуская навука, 2024. 507 с.)[1] как методологически новаторское комплексное исследование Великой войны в жанре интеллектуальной истории. Автор раскрывает ход и различные аспекты Первой мировой войны, опираясь на опубликованные на протяжении 1914–1941 гг. источники, созданные ее участниками и современниками. В книге рассматривается также историографическая рефлексия Первой мировой войны в научных исследованиях межвоенного времени. Книга осмысливается как многоуровневый нарратив, представляющий совокупность и систему текстов – собственно авторского, текстов источников и научных работ, созданных на протяжении 1914–1941 гг., а также гипертекста самой книги в единстве ее иллюстративной и текстовой составляющей. Представленная книга выступает примером гибридного жанра, соединяя в себе исторический нарратив, источниковедческое исследование и историографическую рефлексию, являясь одновременно ярким примером работы в парадигме интеллектуальной истории. Автор создает собственную конструкцию исторической памяти о Первой мировой войне, что весьма востребовано в актуальных социокультурных и политических реалиях.
The article reviews the book of Doctor of Historical Sciences, Professor I.R. Chikalova "[Not] forgotten war: World War I in documents, journalism, memoirs and studies of contemporaries (1914-1941)," 2nd ed., Addendum and revision. (Minsk: Belarusian Navuk, 2024. 507 pp.) As a methodologically innovative comprehensive study of the Great War in the genre of intellectual history. The author reveals the course and various aspects of the First World War, relying on published during 1914-1941. sources created by its participants and contemporaries. The book also considers the historiographic reflection of the First World War in scientific studies of interwar times. The book is understood as a multi-level narrative, representing the totality and system of texts - actually author's, texts of sources and scientific works created during 1914-1941, as well as the hypertext of the book itself in the unity of its illustrative and textual component. The presented book is an example of a hybrid genre, combining historical narrative, source study and historiographic reflection, while being a vivid example of work in the paradigm of intellectual history. The author creates his own construction of historical memory of the First World War, which is in great demand in current socio-cultural and political realities.
Konkordatowa zasada współdziałania na rzecz obrony i poszanowania instytucji małżeństwa
Authors: Poniatowski Michał 
Published: December 2024

W artykule jest przedstawiona analiza konkordatowej zasady współdziałania na rzecz obrony i poszanowania instytucji małżeństwa w zakresie polskiego porządku prawnego. W aspekcie komparatystycznym są również przedstawione wybrane normy zawarte w innych konkordatach współczesnych. Analiza dotyczy wpierw określenia stron współdziałania, w szczególności w kontekście możliwości interpretacji rozszerzającej poza same strony tej umowy międzynarodowej. Artykuł zawiera również określenie przedmiotu tego współdziałania, w tym w relacji do aktów normatywnych wyższego i niższego rzędu, w których także zawarto zobowiązanie do współdziałania. Analiza obejmuje również formę współdziałania na rzecz obrony i poszanowania instytucji małżeństwa zarówno w aspekcie bezpośrednim, jak i pośrednim. W zakończeniu zawarte są wnioski ogólne z przeprowadzonej analizy.
Piecza nad małoletnim dzieckiem oraz obowiązki alimentacyjne wobec niego w wyroku c. Caberletti z dnia 4 kwietnia 2017 roku
Authors: Kamiński Rafał 
Published: December 2024

W artykule dokonano analizy jednego aspektu orzeczenia Roty Rzymskiej, a mianowicie powierzenia pieczy nad małoletnim dzieckiem i obowiązku alimentacyjnego wobec niego. Nie jest to sytuacja częsta gdy sąd kościelny wypowiada się na temat związany z zabezpieczeniem praw związanych z utrzymaniem potomstwa. Przedmiotowe małżeństwo, którego dotyczy wyrok zostało zawarte w Libanie, gdzie małżeństwa są możliwe tylko w formie wyznaniowej, stąd też w sprawach stanu osób i rodziny (Statut Personnel) obowiązuje prawo związku wyznaniowego, do którego należą strony. Z tego powodu to sąd kościelny (w pierwszej instancji) zawarł w swoim wyroku postanowienia dotyczące pieczy nad małoletnim i zasądził alimenty na jego rzecz od ojca. W analizowanym wyroku rotalnym szczególnie interesujące było nie tyle samo rozstrzygnięcie, ile uzasadnienie prawne, na podstawie którego sąd do niego doszedł.