bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased risk of acquisition and transmission of ESBL-producing Enterobacteriaceae in malnourished children exposed to amoxicillin
Authors: Maataoui Naouale , Langendorf Céline , Berthe Fatou , Bayjanov Jumamurat R , van Schaik Willem , Isanaka Sheila , Grais Rebecca F , Clermont Olivier , Andremont Antoine , Armand-Lefèvre Laurence , Woerther Paul-Louis 
Published: November 2019

AbstractObjectivesRoutine amoxicillin for children with uncomplicated severe acute malnutrition raises concerns of increasing antibiotic resistance. We performed an ancillary study nested within a double-blind, placebo-controlled trial in Niger testing the role of routine 7 day amoxicillin therapy in nutritional recovery of children 6 to 59 months of age with uncomplicated severe acute malnutrition.MethodsWe screened 472 children for rectal carriage of ESBL-producing Enterobacteriaceae (ESBL-E) as well as their household siblings under 5 years old, at baseline and Week 1 (W1) and Week 4 (W4) after start of therapy, and characterized strains by WGS. ClinicalTrials.gov: NCT01613547.ResultsCarriage in index children at baseline was similar in the amoxicillin and the placebo groups (33.8% versus 27.9%, P = 0.17). However, acquisition of ESBL-E in index children at W1 was higher in the amoxicillin group than in the placebo group (53.7% versus 32.2%, adjusted risk ratio = 2.29, P = 0.001). Among 209 index and sibling households possibly exposed to ESBL-E transmission, 16 (7.7%) had paired strains differing by ≤10 SNPs, suggesting a high probability of transmission. This was more frequent in households from the amoxicillin group than from the placebo group [11.5% (12/104) versus 3.8% (4/105), P = 0.04].ConclusionsAmong children exposed to amoxicillin, ESBL-E colonization was more frequent and the risk of transmission to siblings higher. Routine amoxicillin should be carefully balanced with the risks associated with ESBL-E colonization.
Temporal Dynamics of the Blueberry Maggot Fly (Diptera: Tephritidae) and its Primary Parasitoid, Biosteres melleus (Hymenoptera: Braconidae), in the Maine Wild Blueberry System
Authors: Drummond Francis A , Collins Judith A 
Published: November 2019

AbstractBetween 1998 and 2017, we conducted studies in wild blueberry, Vaccinium angustifolium Aiton (Ericales: Ericaceae), to elucidate the temporal dynamics of the blueberry maggot fly, Rhagoletis mendax Curran, and its parasitoid, Biosteres melleus (Gahan). A predictive model for the emergence of R. mendax was validated at two sites over 3 yr. A second predictive model for the major parasitoid, B. melleus, of R. mendax was constructed and suggests that the delay in emergence of the parasitoid relative to its host provides a period or ‘biological window’ of 9 d where insecticide sprays can be applied to manage R. mendax with a limited impact on the parasitoid. A 20-yr study on the parasitoid/host dynamics showed parasitism rates ranging from 0.5 to 28.2%. It appears that R. mendax populations in Maine wild blueberry are characterized by stable equilibrium dynamics, significantly affected by stochastic processes. There was a weak, but significant relationship between B. melleus density and R. mendax intrinsic rates of growth. Our data suggest that R. mendax population dynamics in wild blueberry is characterized by an unstable equilibrium tipping point of 7.9 maggots per liter of blueberries or an average of 10 flies per trap.
Collective intelligence approaches in interactive evolutionary multi-objective optimization
Authors: Cinalli Daniel , Martí Luis , Sanchez-Pi Nayat , Cristina Bicharra Garcia Ana 
Published: November 2019

AbstractEvolutionary multi-objective optimization algorithms (EMOAs) have been successfully applied in many real-life problems. EMOAs approximate the set of trade-offs between multiple conflicting objectives, known as the Pareto optimal set. Reference point approaches can alleviate the optimization process by highlighting relevant areas of the Pareto set and support the decision makers to take the more confident evaluation. One important drawback of this approaches is that they require an in-depth knowledge of the problem being solved in order to function correctly. Collective intelligence has been put forward as an alternative to deal with situations like these. This paper extends some well-known EMOAs to incorporate collective preferences and interactive techniques. Similarly, two new preference-based multi-objective optimization performance indicators are introduced in order to analyze the results produced by the proposed algorithms in the comparative experiments carried out.
Use it or lose it? Ukraine amends its law on GIs*
Authors: Kyrylenko Anastasiia 
Published: November 2019

Abstract
Law of Ukraine ‘On the amendments to certain legal acts of Ukraine concerning the legal protection of geographical indications’, No 123-IX, 20 September 2019
Ukraine has recently amended its basic legislation on geographical indications (GIs) (Law of Ukraine ‘On protection of geographical indications’, No 752-XIV, 16 June 1999). The amendments, modelled upon EU Regulation No 1151/2012 on quality schemes for agricultural products and foodstuffs, entered into force on 1 January 2020 and are aimed at bringing Ukrainian legislation in compliance with the EU/Ukraine free trade agreement.
The radial distribution of supernovae compared to star formation tracers
Authors: Audcent-Ross Fiona M , Meurer Gerhardt R , Audcent James R , Ryder Stuart D , Wong O I , Phan J , Williamson A , Kim J H 
Published: November 2019

ABSTRACT
Given the limited availability of direct evidence (pre-explosion observations) for supernova (SN) progenitors, the location of supernovae (SNe) within their host galaxies can be used to set limits on one of their most fundamental characteristics, their initial progenitor mass. We present our constraints on SN progenitors derived by comparing the radial distributions of 80 SNe in the Survey for Ionised Neutral Gas Galaxies (SINGG) and Survey of Ultraviolet emission in Neutral Gas Galaxies (SUNGG) to the R-band, H α, and UV light distributions of the 55 host galaxies. The strong correlation of Type Ia SNe with R-band light is consistent with models containing only low-mass progenitors, reflecting earlier findings. When we limit the analysis of Type II SNe to apertures containing 90 per cent of the total flux, the radial distribution of these SNe best traces far-ultraviolet emission, consistent with recent direct detections indicating Type II SNe have moderately massive red supergiant progenitors. Stripped-envelope (SE) SNe have the strongest correlation with H α fluxes, indicative of very massive progenitors (M* ≳ 20 M⊙). This result contradicts a small, but growing, number of direct detections of SE SN progenitors, indicating they are moderately massive binary systems. Our result is consistent, however, with a recent population analysis, suggesting binary SE SN progenitor masses are regularly underestimated. SE SNe are centralized with respect to Type II SNe and there are no SE SNe recorded beyond half the maximum disc radius in the optical and one third the disc radius in the ultraviolet. The absence of SE SNe beyond these distances is consistent with reduced massive star formation efficiencies in the outskirts of the host galaxies.
The Loci of Behavioral Evolution: Evidence That Fas2 and tilB Underlie Differences in Pupation Site Choice Behavior between Drosophila melanogaster and D. simulans
Authors: Pischedda Alison , Shahandeh Michael P , Turner Thomas L 
Published: November 2019

AbstractThe behaviors of closely related species can be remarkably different, and these differences have important ecological and evolutionary consequences. Although the recent boom in genotype–phenotype studies has led to a greater understanding of the genetic architecture and evolution of a variety of traits, studies identifying the genetic basis of behaviors are, comparatively, still lacking. This is likely because they are complex and environmentally sensitive phenotypes, making them difficult to measure reliably for association studies. The Drosophila species complex holds promise for addressing these challenges, as the behaviors of closely related species can be readily assayed in a common environment. Here, we investigate the genetic basis of an evolved behavioral difference, pupation site choice, between Drosophila melanogaster and D. simulans. In this study, we demonstrate a significant contribution of the X chromosome to the difference in pupation site choice behavior between these species. Using a panel of X-chromosome deficiencies, we screened the majority of the X chromosome for causal loci and identified two regions associated with this X-effect. We then collect gene disruption and RNAi data supporting a single gene that affects pupation behavior within each region: Fas2 and tilB. Finally, we show that differences in tilB expression correlate with the differences in pupation site choice behavior between species. This evidence associating two genes with differences in a complex, environmentally sensitive behavior represents the first step toward a functional and evolutionary understanding of this behavioral divergence.
PDCT-17 (LTBK-11). PNOC007: H3.3K27M SPECIFIC PEPTIDE VACCINE COMBINED WITH POLY-ICLC FOR THE TREATMENT OF NEWLY DIAGNOSED HLA-A2+ H3.3K27M MIDLINE GLIOMAS
Authors: Mueller Sabine , Lulla Rishi , Goldman Stewart , Banerjee Anu , Chi Susan , Whipple Nicholas , Crawford John , Gauvain Karen , Nazemi Kellie , Nazarian Javad , Taitt Jared , Watchmaker Payal , Nejo Takahide , Okada Kaori , Butterfield Lisa , Molinaro Annette , Prados Michael , Okada Hideho 
Published: November 2019

Abstract

OBJECTIVE
To assess within a multi-center trial the safety of H3.3K27M specific peptide vaccine in combination with poly-ICLC in HLA-A02.01+ patients diagnosed with H3.3K27M+ diffuse midline gliomas.

METHODS
Subjects 3–21 years of age with CLIA confirmed H3.3K27 mutation status were eligible. Patients were enrolled after completion of focal radiation therapy. The trial enrolled two strata: Stratum A included newly diagnosed patients with diffuse intrinsic pontine glioma (DIPG) (n=19); Stratum B included non-DIPG midline glioma patients including spinal cord tumors as an exploratory strata (n=10). The H3.3K27M vaccine was administered in combination with poly-ICLC every 3 weeks for a total of 8 doses followed by every 6 weeks for a maximum of 96 weeks of therapy. Immuno-monitoring and imaging occurred every 3 months. Modified iRANO criteria are used for ongoing assessment of disease status. Patients’ peripheral blood mononuclear cell (PBMC) samples were evaluated by mass cytometry.

RESULTS
From November 2016 until March 2019, 19 eligible patients (median age 11, range 5–17 yrs; 53 % female) were enrolled in Stratum A and 10 eligible patients (median age 13, range 7–18 yrs; 60 % female) in Stratum B. Treatment was well tolerated with 7 grade 3 and 0 grade 4 treatment related toxicities. The most common related side effect included injection site reaction. Median number of vaccine administrations per patient was 6 (range 1–11). Overall survival at 12 months was 40% (95% CI 22–73%) for Stratum A and 39% (95% CI 16–93%) for Stratum B. A mass cytometry-based analysis of patient PBMCs (n = 16) revealed a trend towards an inverse correlation between polymorphonuclear myeloid-derived suppressor cells and the expansion of H3.3K27M-specific CD8+ T-cells (p-value = 0.154).

CONCLUSION
H3.3K27M specific vaccine in combination with poly-ICLC is well tolerated. Further evaluation will include a combination with checkpoint inhibitor nivolumab.
Methods for mapping the impact of social sciences and humanities—A literature review
Authors: Pedersen David Budtz , Grønvad Jonas Følsgaard , Hvidtfeldt Rolf 
Published: November 2019

AbstractThis article explores the current literature on ‘research impact’ in the social sciences and humanities (SSH). By providing a comprehensive review of available literature, drawing on national and international experiences, we take a systematic look at the impact agenda within SSH. The primary objective of this article is to examine key methodological components used to assess research impact comparing the advantages and disadvantages of each method. The study finds that research impact is a highly complex and contested concept in the SSH literature. Drawing on the strong methodological pluralism emerging in the literature, we conclude that there is considerable room for researchers, universities, and funding agencies to establish impact assessment tools directed towards specific missions while avoiding catch-all indicators and universal metrics.
IQGAP1 restrains T‐cell cosignaling mediated by OX40
Authors: Okuyama Yuko , Nagashima Hiroyuki , Ushio‐Fukai Masuko , Croft Michael , Ishii Naoto , So Takanori 
Published: November 2019

AbstractA costimulatory signal from the tumor necrosis factor receptor (TNFR) family molecule OX40 (CD134), which is induced on activated T cells, is important for T‐cell immunity. Aberrant OX40 cosignaling has been implicated in autoimmune and inflammatory disorders. However, the molecular mechanism by which the OX40 cosignaling regulates the T‐cell response remains obscure. We found that OX40 associated with a scaffold protein, IQ motif‐containing GTPase‐activating protein 1 (IQGAP1) after ligation by its ligand OX40L. Naïve CD4+ T cells from Iqgap1−/− mice displayed enhanced proliferation and cytokine secretion upon receiving OX40 cosignaling. A C‐terminal IQGAP1 region was responsible for its association with OX40, and TNFR‐associated factor 2 (TRAF2) bridged these two proteins. The enhanced cytokine response in Iqgap1−/− T cells was restored by the expression of the C‐terminal IQGAP1. Thus, the IQGAP1 binding limits the OX40 cosignaling. Disease severity of experimental autoimmune encephalomyelitis (EAE) was significantly exacerbated in Iqgap1−/− mice as compared to wild‐type mice. Additionally, recipient mice with Iqgap1−/− donor CD4+ T cells exhibited significantly higher EAE scores than those with their wild‐type counterparts, and OX40 blockade led to a significant reduction in the EAE severity. Thus, our study defines an important component of the OX40 cosignaling that restricts inflammation driven by antigen‐activated T cells.
Drug-induced anti-neutrophil cytoplasmic antibody-associated vasculitis
Authors: Weng Cheng-Hua , Liu Zhi-Chun 
Published: November 2019

Abstract

Objective:
In recent years, an increasing number of drugs have been proved to be associated with the induction of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). This article reviews the latest research progress on drug-induced AAV.

Data sources:
We conducted a comprehensive and detailed search of the PubMed database. The search terms mainly included drug-induced, ANCA, and vasculitis.

Study selection:
We summarized the original articles and reviews on drug-induced AAV in recent years. The extracted information included the definition, epidemiology, associated drugs, pathogenesis, clinical features, diagnosis, treatment, and prognosis of drug-induced AAV. We also focused on the differences between drug-induced AAV and primary vasculitis.

Results:
The offending drugs leading to drug-induced AAV are almost from pharmacologic categories and we need to be vigilant when using these drugs. The pathogenesis of drug-induced AAV might be multifactorial. The formation of neutrophil extracellular traps is an important mechanism for the development of drug-induced AAV. The clinical features of drug-induced AAV are similar to those of primary AAV. Understanding the difference between drug-induced AAV and primary AAV is helpful to identify drug-induced AAV. Stopping the offending drug at once after diagnosis may be sufficient for those patients with mild symptoms. Immunosuppressive therapy should only be used in patients with vital organs involvement.

Conclusions:
Patients with drug-induced AAV usually have a good prognosis if they stop using the offending drug immediately. Recent advances in research on AAV are expected to help us better understand the pathogenesis of drug-induced AAV.
Lung transplantation in China between 2015 and 2018
Authors: Hu Chun-Xiao , Chen Wen-Hui , He Jian-Xing , Jiang Ge-Ning , Li Xiao-Shan , Wei Dong , Wu Bo , Zhang Ji , Wang Chen , Chen Jing-Yu 
Published: November 2019

Abstract

Background:
Lung transplantation (LT) has been demonstrated as the only effective therapy for patients with end-stage lung diseases. Increasing listed lung transplant candidates and expanding volumes of lung transplant centers across China require well-organized programs and registry data collection based on the large population. This study aimed to summarize and analyze the data of LT development in China.

Methods:
We retrospectively collected and analyzed data from the China Lung Transplantation Registry (CLuTR). Key data were reported from the registry with transplant types, indications, donor and recipient characteristics, outcomes and survival. The survival <30 days, 1-year and 3-year survival rates were estimated with risk factors identified.

Results:
CLuTR contained data from 1053 lung transplants performed through January 1st, 2015 to December 31st, 2018 reported by 18 registered transplant centers. The largest category of diagnosis before transplantation was idiopathic interstitial pneumonitis. The total <30 days, 1-year and 3-year survival rates in CLuTR were 81.45%, 70.11%, and 61.16% with discrepancy by indications. Large proportion of recipients who were more than 60 years old required higher standard of care. Infection-related complications resulted in more death events in the early post-surgery periods. New York Heart Association grading at listing, extra-corporeal membrane oxygenation usage peri-transplantation, allograft dysfunction (primary graft dysfunction >Grade 0), renal insufficiency (estimated glomerular filtration rate <60 mL·min–1·1.73 m–2), were independently associated with a higher risk for 3-year mortality in the entire cohort.

Conclusions:
Facing more end-stage of lung diseases and comorbidities, this study analyzed the outcomes and survival of LT recipients in China. Further prospectively stratified analyses with longer follow-up will be needed.
Launching a Mohs Surgery Program
Authors: Wysong Ashley , Sutton Adam 
Published: November 2019

BACKGROUND
There is a paucity of data or publications in the literature on best practices for opening a new Mohs surgery unit.

OBJECTIVE
The goal of this article is to be a “how to” guide for starting a Mohs and dermatologic surgery practice.

MATERIALS AND METHODS
Two academic Mohs surgeons share their personal experiences and data from the literature.

RESULTS
Topics discussed include picking a location and identifying space, equipment, staffing, regulatory practices, policies and procedures, marketing and outreach, patient experience, building culture, clinic efficiency, and vision.

CONCLUSION
Although opening a new Mohs surgery unit is challenging, it can be rewarding to have the opportunity to develop best practices and systems that create a wonderful working environment and allow for exceptional care of patients.
Transmission Modeling with Regression Adjustment for Analyzing Household-based Studies of Infectious Disease
Authors: Crawford Forrest W. , Marx Florian M. , Zelner Jon , Cohen Ted 
Published: November 2019

Background:
Household contacts of people infected with a transmissible disease may be at risk due to this proximate exposure, or from other unobserved sources. Understanding variation in infection risk is essential for targeting interventions.

Methods:
We develop an analytical approach to estimate household and exogenous forces of infection, while accounting for individual-level characteristics that affect susceptibility to disease and transmissibility. We apply this approach to a cohort study conducted in Lima, Peru, of 18,544 subjects in 4,500 households with at least one active tuberculosis (TB) case and compare the results to those obtained by Poisson and logistic regression.

Results:
HIV-coinfected (susceptibility hazard ratio [SHR] = 3.80, 1.56–9.29), child (SHR = 1.72, 1.32–2.23), and teenage (SHR = 2.00, 1.49–2.68) household contacts of TB cases experience a higher hazard of TB than do adult contacts. Isoniazid preventive therapy (SHR = 0.30, 0.21–0.42) and Bacillus Calmette–Guérin (BCG) vaccination (SHR = 0.66, 0.51–0.86) reduce the risk of disease among household contacts. TB cases without microbiological confirmation exert a smaller hazard of TB among their close contacts compared with smear- or culture-positive cases (excess hazard ratio = 0.88, 0.82–0.93 for HIV− cases and 0.82, 0.57–0.94 for HIV+ cases). The extra household force of infection results in 0.01 (95% confidence interval [CI] = 0.004, 0.028) TB cases per susceptible household contact per year and the rate of transmission between a microbiologically confirmed TB case and susceptible household contact at 0.08 (95% CI = 0.045, 0.129) TB cases per pair per year.

Conclusions:
Accounting for exposure to infected household contacts permits estimation of risk factors for disease susceptibility and transmissibility and comparison of within-household and exogenous forces of infection.
TEN-YEAR EPIDEMIOLOGY OF RETINOPATHY OF PREMATURITY TREATMENT IN TAIWAN
Authors: Kang Eugene Yu-Chuan , Hsu Kuang-Hung , Chu Shih-Ming , Lien Reyin , Wang Nan-Kai , Lai Chi-Chun , Chen Kuan-Jen , Hwang Yih-Shiou , Lin Ciao-Ming , Wu Wei-Chi 
Published: November 2019

Purpose:
To understand the epidemiology of retinopathy of prematurity (ROP) requiring treatment in Taiwan from 2002 to 2011.

Methods:
This retrospective cross-sectional study enrolled 11,180 premature patients with a length of stay >28 days who survived during hospitalization. The incidence of the first ROP treatment was analyzed.

Results:
Among ROP patients (n = 4,096), 6.5% (n = 265) received treatment. The most frequently performed treatment was laser administration (n = 199), followed by intravitreal anti–vascular endothelial growth factor (VEGF) injection (n = 38), scleral buckle or pars plana vitrectomy (n = 14), and cryotherapy (n = 14). The incidence of ROP requiring treatment increased during the study period, as did the use of intravitreal anti-VEGF injection. Shifts in the treatment modality from cryotherapy and scleral buckle/pars plana vitrectomy to laser treatment after 2003 and from laser treatment to intravitreal anti-VEGF injection after 2010 were observed.

Conclusion:
In Taiwan, the incidence of the use of intravitreal anti-VEGF injection for treating ROP increased between 2002 and 2011. Laser treatment was less frequently used than intravitreal anti-VEGF injection in 2011.