bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design, Analysis, and Integration of a New Two-Degree-of-Freedom Articulated Multi-Link Robotic Tail Mechanism
Authors: Liu Yujiong , Ben-Tzvi Pinhas 
Published: December 2019

Abstract
Based on observations from nature, tails are believed to help animals achieve highly agile motions. Traditional single-link robotic tails serve as a good simplification for both modeling and implementation purposes. However, this approach cannot explain the complicated tail behaviors exhibited in nature where multi-link structures are more commonly observed. Unlike its single-link counterpart, articulated multi-link tails essentially belong to the serial manipulator family which possesses special motion transmission design challenges. To address this challenge, a cable-driven hyper-redundant design becomes the most used approach. Limited by cable strength and elastic components, this approach suffers from low-frequency response, inadequate generated inertial loading, and fragile hardware, which are all critical drawbacks for robotic tails design. To solve these structure-related shortcomings, a multi-link robotic tail made up of rigid links is proposed in this paper. The new structure takes advantage of the traditional hybrid mechanism architecture, but utilizes rigid mechanisms to couple the motions between the ith link and the (i + 1)th link rather than using cable actuation. By doing so, the overall tail becomes a rigid mechanism that achieves quasi-uniform spatial bending for each segment and allows performing highly dynamic motions. The mechanism and detailed design of this new robotic tail are presented. The kinematic model was developed and an optimization process was conducted to reduce the bending non-uniformity for the rigid tail. Based on this special optimization design, the dynamic model of the new mechanism is significantly simplified. A small-scale three-segment prototype was integrated to verify the proposed mechanism's unique mobility.
Effects of Postexercise Sauna Bathing on Recovery of Swim Performance
Authors: Skorski Sabrina , Schimpchen Jan , Pfeiffer Mark , Ferrauti Alexander , Kellmann Michael , Meyer Tim 
Published: December 2019

Purpose: Despite indications of positive effects of sauna (SAU) interventions, effects on performance recovery are unknown. The aim of the current study was to investigate acute effects of SAU bathing after an intensive training session on recovery of swim performance. Methods: In total, 20 competitive swimmers and triathletes (3 female and 17 male) with a minimum of 2 y of competition experience (national level or higher) participated in the study. Athletes completed an intensive training session followed by either a SAU bathing intervention or a placebo (PLAC) condition in a randomized order. SAU consisted of 3 × 8 min of SAU bathing at 80–85°C, whereas during PLAC, athletes applied a deidentified, pH-balanced massage oil while passively resting in a seated position. Prior to training, swimmers conducted a 4 × 50-m all-out swim test that was repeated on the following morning. Furthermore, subjective ratings of fatigue and recovery were measured. Results: Swimmers performed significantly worse after SAU (4 × 50-m pre–post difference: +1.69 s) than after PLAC (−0.66 s; P = .02), with the most pronounced decrease in the first 50 m (P = .04; +2.7%). Overall performance of 15 athletes deteriorated (+2.6 s). The subjective feeling of stress was significantly higher after SAU than after PLAC (P = .03). Conclusion: Based on published findings, the smallest substantial change in swimming performance is an increase in time of more than 1.2 s; thus, the observed reductions appear relevant for competitive swimmers. According to the current results, coaches and athletes should be careful with postexercise SAU if high-intensity training and/or competitions are scheduled on the following day.
Pliocene short-term climate changes preserved in continental shallow lacustrine-palustrine carbonates: Western Opache Formation, Atacama Desert, Chile
Authors: de Wet Carol B. , de Wet Andrew P. , Godfrey Linda , Driscoll Elizabeth , Patzkowsky Samuel , Xu Chi , Gigliotti Sophia , Feitl Melina 
Published: December 2019

AbstractMultiple climate proxies indicate episodic changes in moisture levels within an ∼1 Ma duration (early–mid Pliocene) interval. Limestones within the Opache Formation, Calama Basin, Atacama Desert region, Chile, contain evidence for wetter and drier periods on short time scales. Proxies include carbonate lithological changes, paleontology (stromatolites, oncolites, gastropods, ostracods and diatoms), O and C stable isotopes, geochemistry, and mineralogical changes (aragonite, calcite, Mg-calcite, dolomite and gypsum) throughout a 30 m stratigraphic section. Stromatolite fossil cyanobacteria dark and light laminations and mesohaline to hypersaline diatom species suggest Pliocene annual seasonality. Short-term changes between wetter and drier conditions indicate that at least this part of the Atacama region was experiencing relatively rapid early–mid Pliocene climate instability. The predominance of limestone in the Opache Formation, in contrast to the 1500 m of Oligocene-Miocene siliciclastic conglomerates and sandstones, interpreted as arid climate alluvium, that underlie it, indicates a shift from arid or hyperarid climate to a semi-arid climate. Semi-arid conditions promoted limestone deposition in a shallow lacustrine-palustrine environment. In this setting, events such as storms with associated surface water flow, erosion, siliciclastic sand, gravel, and intraclast deposition, coupled with significant biological activity, represent sedimentation during more humid periods in a shallow lacustrine depositional environment. In contrast, limestone characterized by mudcracks, Navicula diatoms, and vadose syndepositional cementation, reflect periods of enhanced evaporation, water shallowing, and episodic desiccation, characteristic of a palustrine depositional system. These facies shifts, in conjunction with geochemical and isotopic proxy evidence, yield a sedimentary record of wetter and drier climate shifts.
Compatibility of pentoxifylline and parenteral medications
Authors: Campbell Anna L , Petrovski Michael , Senarathna SMDK Ganga , Mukadam Nabeelah , Strunk Tobias , Batty Kevin T 
Published: December 2019

ObjectiveTo investigate the physical and chemical compatibility of pentoxifylline (PTX) with a range of parenteral medications used in neonatal intensive care.DesignPTX and drug solutions were combined in glass vials, inspected for physical incompatibility and evaluated on the basis of PTX concentrations for chemical compatibility.ResultsNo precipitation, colour change or turbidity was observed in any of the test mixtures. The PTX concentration was approximately 5.5% lower when combined with undiluted calcium gluconate injection (100 mg/mL). The PTX concentration ratios for all other combinations, including diluted calcium gluconate injection (50 mg/mL), were in the range of 99.5%–102%.ConclusionIn simulated Y-site conditions, PTX was found to be compatible with 15 parenteral medications and six total parenteral nutrition solutions. Based on PTX concentration tests, it would be prudent to avoid mixing PTX with undiluted calcium gluconate injection.
Synthesis of qualitative research studies regarding the factors surrounding UK critical care trial infrastructure
Authors: Pattison Natalie , Arulkumaran Nishkantha , O'Gara Geraldine , Connolly Bronwen , Humphreys Sally , Walsh Tim , Hopkins Philip , Dark Paul 
Published: December 2019

Conducting clinical trials in critical care is integral to improving patient care. Unique practical and ethical considerations exist in this patient population that make patient recruitment challenging, including narrow recruitment timeframes and obtaining patient consent often in time-critical situations. Units currently vary significantly in their ability to recruit according to infrastructure and level of research activity.AimTo identify variability in the research infrastructure of UK intensive care units and their ability to conduct research and recruit patients into clinical trials.DesignWe evaluated factors related to intensive care patient enrolment into clinical trials in the UK. This consisted of a qualitative synthesis carried out with two datasets of in-depth interviews (distinct participants across the two datasets) conducted with 27 intensive care consultants (n=9), research nurses (n=17) and trial coordinators (n=1) from 27 units across the UK. Primary and secondary analyses of two datasets (one dataset had been analysed previously) were undertaken in the thematic analysis.FindingsThe synthesis yielded an overarching core theme of normalising research, characterised by motivations for promoting research and fostering research-active cultures within resource constraints, with six themes under this to explain the factors influencing critical care research capacity: organisational, human, study, practical resources, clinician and patient/family factors. There was a strong sense of integrating research in routine clinical practice, and recommendations are outlined.ConclusionsThe central and transferable tenet of normalising research advocates the importance of developing a culture where research is inclusive alongside clinical practice in routine patient care and is a requisite for all healthcare individuals from organisational to direct patient contact level.
Injury from electric scooters in Copenhagen: a retrospective cohort study
Authors: Blomberg Stig Nikolaj Fasmer , Rosenkrantz Oscar Carl Moeller , Lippert Freddy , Collatz Christensen Helle 
Published: December 2019

ObjectiveTo analyse injuries related to manual and electric scooter use from January 2016 up to and including July 2019.SettingElectric scooter rental services were launched in Denmark in January 2019. The services were provided by private companies. Although rules for handling and riding scooters have been established, no reports either before or after introduction of electric scooters anticipated the full extent of use, and injuries to riders and pedestrians.ParticipantsAll patient records mentioning manual or electric scooters. Records were reviewed, and data were stratified according to two groups: manual and electric scooters.InterventionsA predefined survey was completed in all cases where ‘scooter’ was present. This contained variables such as type of scooter, type of participant, mechanism of injury, acuity, intoxication, referral to treatment facility.Outcome measuresAmong incidents involving scooters, summary statistics on continuous and categorical variables of interest were reported.Results468 scooter-related injuries were recorded. We found that manual scooter riders were more likely to be children under the age of 15; fall alone—involving no other party; sustain contusions, sprains and lacerations; and bruise either their fingers or toes. Riders of electric scooters were likely to be 18–25 years, sustain facial bruising and lacerations requiring sutures, and be under the influence of alcohol or drugs. Non-riders of electric scooters were mostly elderly people who tripped over scooters, consequently sustaining moderate to severe injuries.ConclusionThere were two different types of population sustaining injuries from manual and electric scooters, respectively. The proportion of non-riders injured by electric scooters were surprisingly large (17%), and while electric scooters are here to stay, several apparently preventable injuries occur as a result of reckless driving and discarded electric scooters. Current rules for usage might not prevent unnecessary accidents and secure traffic safety and the lives of older individuals.
Care and outcomes of Canadian children hospitalised with periorbital and orbital cellulitis: protocol for a multicentre, retrospective cohort study
Authors: Gill Peter J , Parkin Patricia C , Begum Nurshad , Drouin Olivier , Foulds Jessica , Pound Catherine , Quet Julie , Vomiero Gemma , Wahi Gita , Sakran Mahmoud , Kozlowski Natascha , Bayliss Ann , Kanani Ronik , Sehgal Anupam , Pullenayegum Eleanor M , Reginald Arun , Wolter Nikolaus , Mahant Sanjay 
Published: December 2019

IntroductionSkin and soft tissue infections of the eye can be classified based on anatomic location as either anterior to the orbital septum (ie, periorbital cellulitis) or posterior to the orbital septum (ie, orbital cellulitis). These two conditions are often considered together in hospitalised children as clinical differentiation is difficult, especially in young children. Prior studies have identified variation in management of hospitalised children with orbital cellulitis; however, they have been limited either as single centre studies or by the use of administrative data which lacks clinical details important for interpreting variation in care. We aim to describe the care and outcomes of Canadian children hospitalised with periorbital and orbital cellulitis.Method and analysisThis is a multisite retrospective cohort study including previously healthy children aged 2 months to 18 years admitted to hospital with periorbital or orbital cellulitis from 2009 to 2018. Clinical data from medical records from multiple Canadian hospitals will be collected, including community and academic centres. Demographic characteristics and study outcomes will be summarised using descriptive statistics, including diagnostic testing, antibiotic therapy, adjunctive therapy, surgical intervention and clinical outcomes. Variation will be described and evaluated using χ² test or Kruskal-Wallis test. Generalised linear mixed models will be used to identify predictors of surgical intervention and longer length of stay.Ethics and disseminationApproval of the study by the Research Ethics Board at each participating site has been obtained prior to data extraction. Study results will be disseminated by presentations at national and international meetings and by publications in high impact open access journals. By identifying important differences in management and outcomes by each hospital, the results will identify areas where care can be improved, practice standardised, unnecessary diagnostic imaging reduced, pharmacotherapy rationalised and where trials are needed.
Impact of concussion and severe musculoskeletal injuries on the onset of mental health symptoms in male professional rugby players: a 12-month study
Authors: Kilic Özgür , Hopley Phil , Kerkhoffs Gino M M J , Lambert Mike , Verhagen Evert , Viljoen Wayne , Wylleman Paul , Gouttebarge Vincent 
Published: December 2019

ObjectiveThis study explored the association between concussion or musculoskeletal injuries, and the onset of mental health symptoms (MHS) in male professional rugby players over a 12-month period.MethodsObservational prospective cohort study with three measurements over a follow-up period of 12 months. At baseline, 573 participants provided informed consent. A total of 327 male professional rugby players (62% forwards, 38% backs) completed all follow-up assessments at baseline, 6 months and 12 months. The mean (±SD) age, height and weight of the participants at baseline was 25.9 (±4.4) years, 184.9 (±8.7) cm and 101.5 (±14.6) kg, respectively. Number of musculoskeletal injuries and number of confirmed concussions were assessed through single questions. Symptoms of distress, anxiety/depression, sleep disturbance, adverse alcohol use and eating disorders were assessed using validated questionnaires.ResultsProfessional rugby players who sustained a concussion within 12 months of baseline were more likely to develop MHS with ORs ranging from 1.5 (95% CI 1.0 to 2.1) for distress to 2.0 (1.2 to 3.6) for adverse alcohol use. Players who sustained a severe injury within 12 months of baseline were more likely to develop symptoms anxiety/depression with an OR of 1.5 (1.1 to 2.0). There was no significant association in both groups for other MHS.ConclusionsRugby players who sustained concussion or severe injuries are up to two times more likely to develop symptoms of distress, adverse alcohol use or anxiety/depression.
Relationship between neuropsychiatric disorders and cognitive and behavioural change in MND
Authors: McHutchison Caroline A , Leighton Danielle Jane , McIntosh Andrew , Cleary Elaine , Warner Jon , Porteous Mary , Chandran Siddharthan , Pal Suvankar , Abrahams Sharon 
Published: December 2019

ObjectiveIn this population-based study, we aimed to determine whether neuropsychiatric history, medication or family history of neuropsychiatric disorders predicted cognitive and/or behavioural impairment in motor neuron disease (MND).MethodsPeople with MND (pwMND) on the Scottish Clinical, Audit, Research and Evaluation of MND (CARE-MND) register, diagnosed from January 2015 to January 2018, with cognitive and/or behavioural data measured using the Edinburgh Cognitive and Behavioural ALS Screen were included. Data were extracted on patient neuropsychiatric, medication and family history of neuropsychiatric disorders. We identified patients with cognitive impairment (motor neuron disease with cognitive impairment (MNDci)), behavioural impairment (motor neuron disease with behavioural impairment (MNDbi), both (motor neuron disease with cognitive and behavioural impairment (MNDcbi)) or motor neuron disease–frontotemporal dementia (MND-FTD).ResultsData were available for 305 pwMND (mean age at diagnosis=62.26 years, SD=11.40), of which 60 (19.7%) had a neuropsychiatric disorder. A family history of neuropsychiatric disorders was present in 36/231 (15.58%) of patients. Patient premorbid mood disorders were associated with increased apathy (OR=2.78, 95% CI 1.083 to 7.169). A family history of any neuropsychiatric disorder was associated with poorer visuospatial scores, MNDbi (OR=3.14, 95% CI 1.09 to 8.99) and MND-FTD (OR=5.08, 95% CI 1.26 to 20.40). A family history of mood disorders was associated with poorer overall cognition (exp(b)=0.725, p=0.026), language, verbal fluency and visuospatial scores, and MND-FTD (OR=7.57, 95% CI 1.55 to 46.87). A family history of neurotic disorders was associated with poorer language (exp(b)=0.362, p<0.001), visuospatial scores (exp(b)=0.625, p<0.009) and MND-FTD (OR=13.75, 95% CI 1.71 to 110.86).ConclusionNeuropsychiatric disorders in patients and their families are associated with cognitive and behavioural changes post-MND diagnosis, with many occurring independently of MND-FTD and C9orf72 status. These findings support an overlap between MND, frontotemporal dementia and neuropsychiatric disorders, particularly mood disorders.
Automatic segmentation of cerebral infarcts in follow-up computed tomography images with convolutional neural networks
Authors: Sales Barros Renan , Tolhuisen Manon L , Boers Anna MM , Jansen Ivo , Ponomareva Elena , Dippel Diederik W J , van der Lugt Aad , van Oostenbrugge Robert J , van Zwam Wim H , Berkhemer Olvert A , Goyal Mayank , Demchuk Andrew M , Menon Bijoy K , Mitchell Peter , Hill Michael D , Jovin Tudor G , Davalos Antoni , Campbell Bruce C V , Saver Jeffrey L , Roos Yvo B W E M , Muir Keith W. , White Phil , Bracard Serge , Guillemin Francis , Olabarriaga Silvia Delgado , Majoie Charles B L M , Marquering Henk A 
Published: December 2019

Background and purposeInfarct volume is a valuable outcome measure in treatment trials of acute ischemic stroke and is strongly associated with functional outcome. Its manual volumetric assessment is, however, too demanding to be implemented in clinical practice.ObjectiveTo assess the value of convolutional neural networks (CNNs) in the automatic segmentation of infarct volume in follow-up CT images in a large population of patients with acute ischemic stroke.Materials and methodsWe included CT images of 1026 patients from a large pooling of patients with acute ischemic stroke. A reference standard for the infarct segmentation was generated by manual delineation. We introduce three CNN models for the segmentation of subtle, intermediate, and severe hypodense lesions. The fully automated infarct segmentation was defined as the combination of the results of these three CNNs. The results of the three-CNNs approach were compared with the results from a single CNN approach and with the reference standard segmentations.ResultsThe median infarct volume was 48 mL (IQR 15–125 mL). Comparison between the volumes of the three-CNNs approach and manually delineated infarct volumes showed excellent agreement, with an intraclass correlation coefficient (ICC) of 0.88. Even better agreement was found for severe and intermediate hypodense infarcts, with ICCs of 0.98 and 0.93, respectively. Although the number of patients used for training in the single CNN approach was much larger, the accuracy of the three-CNNs approach strongly outperformed the single CNN approach, which had an ICC of 0.34.ConclusionConvolutional neural networks are valuable and accurate in the quantitative assessment of infarct volumes, for both subtle and severe hypodense infarcts in follow-up CT images. Our proposed three-CNNs approach strongly outperforms a more straightforward single CNN approach.
Specific treatment and outcome of urethrorectal fistula associated with type 1 atresia ani in a juvenile male dog
Authors: Franklin Phil Henry , Cronin Anna Maria , Ladlow Jane , Owen Laura 
Published: December 2019

A four‐month‐old, entire male, German wirehaired pointer presented with tenesmus due to type I atresia ani and with urination observed through this stenosed anal opening. A positive contrast retrograde urethrogram demonstrated a urethrorectal fistula and stricture of the penile urethra. Urine culture revealed heavy mixed bacterial growth, which was treated with appropriate antibiotics. Surgical correction of the congenital urethrorectal fistula was performed via a perineal approach with a 3.5 French catheter placed retrograde into the fistula to facilitate its dissection. The anal stenosis was addressed by surgical anoplasty and the urethral stricture via a scrotal urethrostomy. The dog recovered well with the owner reporting complete resolution of the clinical signs and urination via the urethrostomy site at six months postoperatively. To the authors’ knowledge, this is the first reported case of congenital urethrorectal fistula associated with type 1 atresia ani in a male dog.
Menstrual blood losses and body mass index are associated with serum ferritin concentrations among female varsity athletes
Authors: Mayer Cara , Barker Mikaela K. , Dirk Payge , Moore Kelsey M. , McCrudden Emma , Karakochuk Crystal D. 
Published: December 2019

Preventing and treating iron deficiency are important components in the nutritional care of female varsity athletes, as these interventions may improve aerobic endurance and athletic performance. We examined the factors associated with ferritin concentration in 30 female varsity athletes (18–30 years) at the University of British Columbia in Vancouver, Canada. Biochemical indicators of iron and inflammation status, dietary intake, supplementation practices, weight, height, and menstrual blood losses were assessed. Iron deficiency prevalence was 20% (n = 6/30; inflammation-adjusted ferritin <15 μg/L). Multiple linear regression was used to assess the associations of a number of independent explanatory variables with log-transformed serum ferritin (μg/L) as the continuous outcome variable. A 1-unit increase in body mass index (BMI; kg/m2) was associated with 22% (95% CI: 9%–37%) higher mean ferritin concentrations, and a 1-point increase in menstrual loss score was associated with 1% (95% CI: 1%–2%) lower ferritin concentrations. Hemoglobin and hepcidin concentrations, inflammation biomarkers, consumption of iron supplements in any form or dose for ≥3 days/week, and age were not significantly associated with ferritin concentrations in the final adjusted model.Novelty Estimated monthly menstrual losses and BMI were associated with serum ferritin concentrations in female athletes in our study. These are easy-to-measure, noninvasive measurements that should be considered in the assessment of risk of iron deficiency in female athletes.