bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond forest plots: clinical gestalt and its influence on COPD telemonitoring studies and outcomes review
Authors: Smith Sheree M , Holland Anne E , McDonald Christine F 
Published: December 2019

BackgroundChronic obstructive pulmonary disease (COPD) is a progressive chronic condition. Improvements in therapies have resulted in better patient outcomes. The use of technology such as telemonitoring as an additional intervention is aimed at enhancing care and reducing unnecessary acute hospital service use. The influence of verbal communication between health staff and patients to inform decision making regarding use of acute hospital services within telemonitoring studies has not been assessed.MethodA systematic overview of published systematic reviews of COPD and telemonitoring was conducted using ana prioriprotocol to ascertain the impact of verbal communication in telemonitoring studies on health service outcomes such as emergency department attendances, hospitalisation and hospital length of stay. The search of the following electronic databases: Cochrane Library, Medline, Pubmed, CINAHL, Embase, TROVE, Australian Digital Thesis and Proquest International Dissertations and Theses was conducted in 2017 and updated in September 2019.ResultsSix systematic reviews were identified. All reviews involved home monitoring of COPD symptoms and biometric data. Included reviews reported 5–28 studies with sample sizes ranging from 310 to 2891 participants. Many studies reported in the systematic reviews were excluded as they were telephone support, cost effectiveness studies, and/or did not report the outcomes of interest for this overview. Irrespective of group assignment, verbal communication with the health or research team did not alter the emergency attendance or hospitalisation outcome. The length of stay was longer for those who were assigned home telemonitoring in the majority of studies.ConclusionThis overview of telemonitoring for COPD had small sample sizes and a wide variety of included studies. Communication was not consistent in all included studies. Understanding the context of communication with study participants and the decision-making process for referring patients to various health services needs to be reported in future studies of telemonitoring and COPD.
Relapse in rheumatoid arthritis patients undergoing dose reduction and withdrawal of biologics: are predictable factors more relevant than predictive parameters? An observational prospective real-life study
Authors: Vittecoq Olivier , Desouches Sandra , Kozyreff Marie , Nicolau Julia , Pouplin Sophie , Rottenberg Pascal , Sens Nicolas , Lequerre Thierry , Avenel Gilles 
Published: December 2019

ObjectiveTo determine predictive/predictable factors of relapse in rheumatoid arthritis (RA) patients undergoing biologic Disease-Modifying Anti-Rheumatic Drugs (bDMARDs) dose reduction/discontinuation.Patients and methodsRA patients receiving the same bDMARD for more than 1 year, in Simplified Disease Activity Index (SDAI) remission, were selected in an observational monocentric real-life study. The 18-month follow-up included spacing (6 months) and withdrawal (12 months) periods of bDMARD. Clinical, biological and ultrasonographic (US) parameters were collected regularly. Relapse was defined by SDAI>11.ResultsFifty-three RA patients (mean age: 58 years; 72% women; median duration: 11 years) were enrolled. Forty-two received anti-cytokinic bDMARD targeting tumour necrosis factor (n=39) or interleukin-6R (n=3) and 11 were treated by abatacept. The number of relapses during the spacing and discontinuation periods were 19 and 20, respectively. After 18 months of follow-up, among the 53 patients, 12 maintained bDMARD-free remission, 39 had relapsed and 2 were lost of follow-up. Median time to relapse was 11.8 months. In multivariate analysis, baseline factors predictive of relapse were corticosteroid intake, female gender, longer disease duration and no methotrexate intake with bDMARD. Concerning the survival analysis, also taking into account the factors of predictability, the main risk factor of relapse after discontinuation was an increase of SDAI >0 during the spacing period (p=0.03). US findings were not contributive.ConclusionIn the context of RA in remission under bDMARDs, variation of SDAI during the dose-reduction phase is more relevant than baseline parameters to predict success of drug withdrawal.
Increased hip circumference in individuals with metabolic syndrome affects serum nesfatin-1 levels
Authors: Tekin Tuba , Çiçek Betül , Konyalıgil Nurefşan , Güntürk İnayet , Yazıcı Cevat , Karaca Züleyha , Ünlüsavuran Meltem 
Published: December 2019

AbstractBackgroundThis case–control study was conducted to investigate the relationship between serum nesfatin-1 levels and nutritional status and blood parameters in patients diagnosed with metabolic syndrome.MethodsThirty patients (case) diagnosed with metabolic syndrome according to National Cholesterol Education Program-Adult Treatment Panel III criteria were included. Thirty healthy subjects (control) matched with patients with metabolic syndrome in terms of age, gender and body mass index were included. Three-day food consumption records were obtained. Anthropometric indices were measured and body composition was determined by bioelectrical impedance method. Biochemical parameters and serum nesfatin-1 levels were measured after 8 hours of fasting.ResultsSerum nesfatin-1 levels were 0.245±0.272 ng/mL in the case group and 0.528±0.987 ng/mL in the control group (p&gt;0.05). There was a positive significant correlation between serum nesfatin-1 levels and body weight, waist and hip circumferences in the case group (p&lt;0.05). Each unit increase in hip circumference measurement affects the levels of nesfatin by 0.014 times. In the control group, there was a positive significant correlation between body weight and serum nesfatin-1 levels (p&lt;0.05). A significant correlation was detected between HbA1c and serum nesfatin-1 levels in the case group (p&lt;0.05). A significant relationship was detected between dietary fibre intake and the serum nesfatin-1 levels in the case group (p&lt;0.05).ConclusionsAnthropometric indices and blood parameters were correlated with serum nesfatin-1 levels in patients with metabolic syndrome. More clinical trials may be performed to establish the relationship between serum nesfatin-1 levels and nutritional status.
Initial validation of the electronic form of the Michigan Body Map
Authors: Hassett Afton L , Pierce Jennifer , Goesling Jenna , Fritsch Laura , Bakshi Rishi R , Kohns David J , Brummett Chad M 
Published: December 2019

Background
The Michigan Body Map (MBM) was developed to assess pain location in a reliable and valid manner; however, electronic formats have not been validated. This study had two aims: (1) initial validation of the electronic form of the MBM (eMBM) and (2) preliminary test of assessing pain severity within body zones.

Methods
For the first aim, 68 participants with chronic pain completed paper and electronic forms of the MBM, then underwent scripted interviews to assess preferences among body maps and verbal confirmation of pain locations. For the second aim, a subset of the participants (n=40) completed the Brief Pain Inventory (BPI) pain severity subscale, as well as the eMBM again and endorsed pain severity using additional screens showing body zones that contained areas in which pain was endorsed.

Results
There were few discrepancies between MBM, eMBM and verbal report (1.9% and 1.6%, respectively), and no difference between forms in perceived ability to indicate areas of pain or ease of completion. Patients accurately indicated their bodily pain on both maps, with 84% and 87% reporting one or no errors on MBM and eMBM, respectively. Participants also reported no preference for which version best-depicted areas of pain or best distinguished left from right. Lastly, the most preferred measure was eMBM with pain severity zones, followed by eMBM without zones, followed by the BPI pain severity subscale.

Conclusions
These data support the validity of the eMBM for patients with chronic pain. Further, an expanded form of the eMBM that assesses pain severity was preferred by most participants.
The effects of hydrogen peroxide on mortality, escape response, and oxygen consumption of Calanus spp.
Authors: Escobar-Lux Rosa H. , Fields David M. , Browman Howard I. , Shema Steven D. , Bjelland Reidun M. , Agnalt Ann-Lisbeth , Skiftesvik Anne Berit , Samuelsen Ole B. , Durif Caroline M.F. 
Published: December 2019

Hydrogen peroxide (H2O2), a pesticide used in salmonid aquaculture, is released directly into the environment where nontarget organisms are at risk of exposure. We determined threshold concentrations for mortality of Calanus spp., the dominant zooplankton species in the North Atlantic, and assessed sublethal effects, focusing on the escape response and oxygen consumption rates (OCRs) as behavioral and physiological assays. One-hour exposure to 170 mg·L−1 (i.e., 10% of the recommended H2O2 treatment) was lethal to copepodite stage V (92% mortality) and adult females (100% mortality). The acute median lethal concentration (1h-LC50) was 214.1 (150.67–277.4) and 48.6 (44.9–52.2) mg·L−1 for copepodite V and adults, respectively. The 25-h LC50 was 77.1 (57.9–96.2) and 30.63 (25.4–35.8) mg·L−1 for copepodite V and adults, respectively. At concentrations of 0.5% and 1% of the recommended treatment level, Calanus spp. showed a decrease in escape performance and lower OCRs with increased concentration. At H2O2 concentrations of 5% of the recommended treatment levels (85 mg·L−1), exposed copepods showed no escape reaction response. These results suggest that sublethal concentrations of H2O2 will increase the risk of predation for Calanus spp. Furthermore, this study provides supporting evidence that theoretical “safe” values, traditionally used for predicting toxicity thresholds, underestimate the impact of H2O2 on the physiological condition of nontarget crustaceans.
The influence of stratigraphy and facies distribution on reservoir quality and production performance in the Triassic Skagerrak Formation of the UK and Norwegian Central North Sea
Authors: Gray E. , Hartley A. , Howell J. 
Published: December 2019

Abstract
Stratigraphy, depositional facies and proximal-distal position within a depositional system are identified as controls on reservoir quality and dynamic reservoir performance in the Triassic, fluvial-dominated, Skagerrak Formation reservoirs of the UK and Norwegian Central North Sea. Core sedimentological analysis from across the basin links decreasing trends of channel facies proportion and channel package thickness with increasing floodplain and splay facies proportions and their respective package thicknesses. These trends are considered to represent the proximal to distal transitions of distributive fluvial systems. Depositional facies are shown to strongly control static and theoretical dynamic reservoir quality using porosity–permeability cross-plots and stratigraphically modified Lorenz plots using conventional core plug data. This linkage of stratigraphy, depositional system position, facies proportions and package thicknesses with static and theoretical dynamic reservoir performance is used to predict pressure-depletion profiles in various settings of Triassic reservoirs of the Central North Sea beyond major areas of well and field control in UK Quads 22 and 30.
The importance of surface ruptures and fault damage zones in earthquake hazard assessment: a review and new suggestions
Authors: Jin Kwangmin , Kim Young-Seog 
Published: December 2019

Abstract

Large earthquakes (M
W
>
c.
6) generate surface ruptures and strong ground motions, resulting in extensive property damage and loss of lives. The earthquake damage and causality levels depend, for example, on the earthquake magnitude, seismic wave characteristics, the distance from the epicentre, the depth of earthquake and the foundation of related area . However, these factors cannot all be known for future earthquakes, because the exact times and locations of earthquakes cannot be predicted with the current technology. Thus, it is only possible to prepare for earthquakes by implementing anti-seismic design codes based on the local geological conditions. With accurate information about the locations of active faults or potential surface ruptures and deformation patterns, earthquake-prone areas could be avoided during site selection, especially for important facilities such as nuclear power plants and high-level radioactive waste disposal facilities. In this study, we investigated several factors for earthquake hazard estimation, focusing on the fault damage zones and respect distances. Fault damage zones around faults are mainly controlled by fault types, tip modes, exposed locations and slip senses along the fault. The characteristics of geological faults and earthquake ruptures show asymmetrical displacements and damage patterns, making it difficult to estimate respect distances and surface deformations. Therefore, both the respect distance and fault damage zone should be considered when identifying safe regions. This information will facilitate earthquake hazard assessment and appropriate site selection to reduce earthquake hazards in earthquake-prone areas.
Evidence of giant earthquakes and tsunamis of the seventeenth-century type along the southern Kuril subduction zone, eastern Hokkaido, northern Japan: a review
Authors: Nanayama Futoshi 
Published: December 2019

Abstract

Large earthquakes of magnitude 7–8 occur at intervals of about 70–100 years in the southern Kuril Trench off eastern Hokkaido, northern Japan. However, especially large giant earthquakes (M
w
c.
8.8) have recurred at 300–500 year intervals, and the most recent of these was in the early seventeenth century. Surveys on the Pacific coast of eastern Hokkaido have documented field evidence that includes sharp contacts of peat and mud layers, indicative of coseismic coastal uplift, and large tsunami sand layers. Several proposed fault models of the seventeenth-century giant earthquake have been tested with numerical tsunami simulations. The best of these models incorporates a multi-segment interplate earthquake (M
w
8.8) with large slip near the trench axis. The seventeenth-century giant earthquake and the 1611 Keicho Sanriku tsunami appear to have had different sources because varve counts from Lake Harutori suggest that the seventeenth-century giant earthquake occurred at
c.
1637. Moreover, a consideration of regional tectonics suggests that convergence of the Kuril forearc sliver controls the current topography of eastern Hokkaido. Further progress in understanding the seismicity of this region will benefit from the combined insights of both geologists and seismologists.
Decreased atrioventricular plane displacement after acute myocardial infarction yields a concomitant decrease in stroke volume
Authors: Berg J. , Jablonowski R. , Nordlund D. , Kopic S. , Bidhult S. , Xanthis C. G. , Saeed M. , Solem K. , Arheden H. , Carlsson M. 
Published: December 2019

Acute myocardial infarction (AMI) can progress to heart failure, which has a poor prognosis. Normally, 60% of stroke volume (SV) is attributed to the longitudinal ventricular shortening and lengthening evident in the atrioventricular plane displacement (AVPD) during the cardiac cycle, but there is no information on how the relationship changes between SV and AVPD before and after AMI. Therefore, the aim of this study was to determine how SV depends on AVPD before and after AMI in two swine models. Serial cardiac magnetic resonance imaging was carried out before and 1–2 h after AMI in a microembolization model ( n = 12) and an ischemia-reperfusion model ( n = 14). A subset of pigs ( n = 7) were additionally imaged at 24 h and at 7 days. Cine and late gadolinium enhancement images were analyzed for cardiac function, AVPD measurements and infarct size estimation, respectively. AVPD decreased ( P < 0.05) in all myocardial regions after AMI, with a concomitant SV decrease ( P < 0.001). The ischemia-reperfusion model affected SV to a higher degree and had a larger AVPD decrease than the microembolization model (−29 ± 14% vs. −15 ± 18%; P < 0.05). Wall thickening decreased in infarcted areas ( P < 0.001), and A-wave AVPD remained unchanged ( P = 0.93) whereas E-wave AVPD decreased ( P < 0.001) after AMI. We conclude that AVPD is coupled to SV independent of infarct type but likely to a greater degree in ischemia-reperfusion infarcts compared with microembolization infarcts. AMI reduces diastolic early filling AVPD but not AVPD from atrial contraction. These findings shed light on the physiological significance of atrioventricular plane motion when assessing acute and subacute myocardial infarction. NEW & NOTEWORTHY The link between cardiac longitudinal motion, measured as atrioventricular plane displacement (AVPD), and stroke volume (SV) is investigated in swine after acute myocardial infarction (AMI). This cardiac magnetic resonance study demonstrates a close coupling between AVPD and SV before and after AMI in an experimental setting and demonstrates that this connection is present in ischemia-reperfusion and microembolization infarcts, acutely and during the first week. Furthermore, AVPD is equally and persistently depressed in infarcted and remote myocardium after AMI.
Cell Adhesiveness Serves as a Biophysical Marker for Metastatic Potential
Authors: Beri Pranjali , Popravko Anna , Yeoman Benjamin , Kumar Aditya , Chen Kevin , Hodzic Enio , Chiang Alyssa , Banisadr Afsheen , Placone Jesse K. , Carter Hannah , Fraley Stephanie I. , Katira Parag , Engler Adam J. 
Published: December 2019

Abstract

Tumors are heterogeneous and composed of cells with different dissemination abilities. Despite significant effort, there is no universal biological marker that serves as a metric for metastatic potential of solid tumors. Common to disseminating cells from such tumors, however, is the need to modulate their adhesion as they detach from the tumor and migrate through stroma to intravasate. Adhesion strength is heterogeneous even among cancer cells within a given population, and using a parallel plate flow chamber, we separated and sorted these populations into weakly and strongly adherent groups; when cultured under stromal conditions, this adhesion phenotype was stable over multiple days, sorting cycles, and common across all epithelial tumor lines investigated. Weakly adherent cells displayed increased migration in both two-dimensional and three-dimensional migration assays; this was maintained for several days in culture. Subpopulations did not show differences in expression of proteins involved in the focal adhesion complex but did exhibit intrinsic focal adhesion assembly as well as contractile differences that resulted from differential expression of genes involved in microtubules, cytoskeleton linkages, and motor activity. In human breast tumors, expression of genes associated with the weakly adherent population resulted in worse progression-free and disease-free intervals. These data suggest that adhesion strength could potentially serve as a stable marker for migration and metastatic potential within a given tumor population and that the fraction of weakly adherent cells present within a tumor could act as a physical marker for metastatic potential.

Significance:
Cancer cells exhibit heterogeneity in adhesivity, which can be used to predict metastatic potential.
NAMPT Inhibition Suppresses Cancer Stem-like Cells Associated with Therapy-Induced Senescence in Ovarian Cancer
Authors: Nacarelli Timothy , Fukumoto Takeshi , Zundell Joseph A. , Fatkhutdinov Nail , Jean Stephanie , Cadungog Mark G. , Borowsky Mark E. , Zhang Rugang 
Published: December 2019

AbstractEpithelial ovarian cancer (EOC) is the most lethal of gynecologic malignancies. The standard-of-care treatment for EOC is platinum-based chemotherapy such as cisplatin. Platinum-based chemotherapy induces cellular senescence. Notably, therapy-induced senescence contributes to chemoresistance by inducing cancer stem-like cells (CSC). However, therapeutic approaches targeting senescence-associated CSCs remain to be explored. Here, we show that nicotinamide phosphoribosyltransferase (NAMPT) inhibition suppresses senescence-associated CSCs induced by platinum-based chemotherapy in EOC. Clinically applicable NAMPT inhibitors suppressed the outgrowth of cisplatin-treated EOC cells both in vitro and in vivo. Moreover, a combination of the NAMPT inhibitor FK866 and cisplatin improved the survival of EOC-bearing mice. These phenotypes correlated with inhibition of the CSCs signature, which consists of elevated expression of ALDH1A1 and stem-related genes, high aldehyde dehydrogenase activity, and CD133 positivity. Mechanistically, NAMPT regulates EOC CSCs in a paracrine manner through the senescence-associated secretory phenotype. Our results suggest that targeting NAMPT using clinically applicable NAMPT inhibitors, such as FK866, in conjunction with platinum-based chemotherapy represents a promising therapeutic strategy by suppressing therapy-induced senescence-associated CSCs.Significance:This study highlights the importance of NAMPT-mediated NAD+ biosynthesis in the production of cisplatin-induced senescence-associated cancer stem cells, as well as tumor relapse after cisplatin treatment.
Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis
Authors: Liu Sijia , González-Prieto Román , Zhang Mengdi , Geurink Paul P. , Kooij Raymond , Iyengar Prasanna Vasudevan , van Dinther Maarten , Bos Erik , Zhang Xiaobing , Le Dévédec Sylvia E. , van de Water Bob , Koning Roman I. , Zhu Hong-Jian , Mesker Wilma E. , Vertegaal Alfred C.O. , Ovaa Huib , Zhang Long , Martens John W.M. , ten Dijke Peter 
Published: December 2019

Abstract

Purpose:
Therapies directed to specific molecular targets are still unmet for patients with triple-negative breast cancer (TNBC). Deubiquitinases (DUB) are emerging drug targets. The identification of highly active DUBs in TNBC may lead to novel therapies.

Experimental Design:
Using DUB activity probes, we profiled global DUB activities in 52 breast cancer cell lines and 52 patients' tumor tissues. To validate our findings in vivo, we employed both zebrafish and murine breast cancer xenograft models. Cellular and molecular mechanisms were elucidated using in vivo and in vitro biochemical methods. A specific inhibitor was synthesized, and its biochemical and biological functions were assessed in a range of assays. Finally, we used patient sera samples to investigate clinical correlations.

Results:
Two DUB activity profiling approaches identified UCHL1 as being highly active in TNBC cell lines and aggressive tumors. Functionally, UCHL1 promoted metastasis in zebrafish and murine breast cancer xenograft models. Mechanistically, UCHL1 facilitates TGFβ signaling–induced metastasis by protecting TGFβ type I receptor and SMAD2 from ubiquitination. We found that these responses are potently suppressed by the specific UCHL1 inhibitor, 6RK73. Furthermore, UCHL1 levels were significantly increased in sera of patients with TNBC, and highly enriched in sera exosomes as well as TNBC cell–conditioned media. UCHL1-enriched exosomes stimulated breast cancer migration and extravasation, suggesting that UCHL1 may act in a paracrine manner to promote tumor progression.

Conclusions:
Our DUB activity profiling identified UCHL1 as a candidate oncoprotein that promotes TGFβ-induced breast cancer metastasis and may provide a potential target for TNBC treatment.