bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of smartphone-based cough data in amyotrophic lateral sclerosis as a potential predictor of functional disability
Authors: Rocha Pedro S. , Bento Nuno , Folgado Duarte , Carreiro André V. , Santos Miguel Oliveira , de Carvalho Mamede , Miranda Bruno 
Published: December 2024

Objectives
Cough dysfunction is a feature of patients with amyotrophic lateral sclerosis (ALS). The cough sounds carry information about the respiratory system and bulbar involvement. Our goal was to explore the association between cough sound characteristics and the respiratory and bulbar functions in ALS.

Methods
This was a single-center, cross-sectional, and case-control study. On-demand coughs from ALS patients and healthy controls were collected with a smartphone. A total of 31 sound features were extracted for each cough recording using time-frequency signal processing analysis. Logistic regression was applied to test the differences between patients and controls, and in patients with bulbar and respiratory impairment. Support vector machines (SVM) were employed to estimate the accuracy of classifying between patients and controls and between patients with bulbar and respiratory impairment. Multiple linear regressions were applied to examine correlations between cough sound features and clinical variables.

Results
Sixty ALS patients (28 with bulbar dysfunction, and 25 with respiratory dysfunction) and forty age- and gender-matched controls were recruited. Our results revealed clear differences between patients and controls, particularly within the frequency-related group of features (AUC 0.85, CI 0.79–0.91). Similar results were observed when comparing patients with and without bulbar dysfunction. Sound features related to intensity displayed the strongest correlation with disease severity, and were the most significant in distinguishing patients with and without respiratory dysfunction.

Discussion
We found a good relationship between specific cough sound features and clinical variables related to ALS functional disability. The findings relate well with some expected impact from ALS on both respiratory and bulbar contributions to the physiology of cough. Finally, our approach could be relevant for clinical practice, and it also facilitates home-based data collection.
Economic evaluation of an adjunctive intraocular and peri-ocular steroid vitreoretinal surgery for open globe trauma: Cost-effectiveness of the ASCOT randomised controlled trial
Authors: Ezeofor Victory ‘Segun , Anthony Bethany F. , Bryning Lucy , Casswell Edward J. , Cro Suzie , Cornelius Victoria R. , Bunce Catey , Robertson Elizabeth , Kelly Joanna , Murphy Caroline , Banerjee Philip J. , Charteris David G. , Edwards Rhiannon Tudor 
Published: December 2024

Background
In the United Kingdom, it is estimated that 5,000 patients sustain eye injuries or ocular trauma requiring hospital admission annually, of which 250 patients will be permanently blinded. This study explores the cost-effectiveness of Adjunctive Steroid Combination in Ocular Trauma (ASCOT) given during surgery versus standard treatment in vitreoretinal surgery in patients with open globe trauma.

Methods
This economic evaluation was embedded alongside the ASCOT RCT (ClinicalTrials.gov Identifier: NCT02873026). We conducted a primary cost-effectiveness analysis from a National Health Service perspective using the proportion of patients who achieved a visual acuity of 10 or more letter improvement on the Early Treatment Diabetic Retinopathy Study (ETDRS) scale as the measure of effect, in developing incremental cost-effectiveness ratios (ICERs). Secondary cost-utility analysis using the EuroQol 5 Dimension 5 Level (EQ-5D-5L) to generate a cost per quality-adjusted life-year (QALY), and a cost-effectiveness analysis using vision-specific quality of life (QoL) was conducted. Sensitivity analyses were also applied to investigate parameter uncertainties.

Results
The sample size of the ASCOT intervention arm and standard care arm of this study was 130 and 129, respectively. The intervention cost per patient was estimated at £132. The proportion of participants with an ETDRS of 10 or more letter improvement was 0.47 for the ASCOT group with a mean cost of £5,526 per patient, while the standard care group had an effect of 0.43 with a mean cost of £5,099 per patient. The ICER value of the primary outcome was £12,178 per 10 or more letter improvement on the ETDRS score. The secondary result in terms of cost per QALYs gained had a probability of 44% being cost-effective at a willingness-to-pay threshold of £30,000/QALY gained.

Conclusions
Though there is no formally accepted cost-effectiveness willingness-to-pay threshold for 10-letter or more improvement, the ASCOT intervention for open globe trauma is a low-cost intervention. The ASCOT intervention is not cost-effective when compared to the standard care in this group and setting. The proportion of patients in the ASCOT intervention arm with 10 or more letter improvement produced some positive results but this is outweighed by the costs.
Level of health literacy and associated factors among Jimma town public high school adolescent students: A cross-sectional study
Authors: Jatu Merga Garoma , Beyene Desalew Tilahun , W. Senbat Dechasa Befikadu , Alemayehu Tesfaye Asfaw , Hailu Diribsa Tizazu , Jima Serkalem Aschalew , Kitila Midhagsaa Dhinsa , Kebede Ebissa Bayana 
Published: December 2024

Objectives
This study aimed to assess the level of health literacy and its associated factors among Jimma town public high school adolescents, Jimma, Oromia, Southwest Ethiopia, 2023.

Methods
A facility-based cross-sectional study was conducted in June 2023 among 604 Jimma town public high school adolescents. A multistage sampling technique was employed to recruit study participants. A pretested self-administered questionnaire was used to collect data. Data was entered into epidata 4.6 and exported to SPSS version 26.0 for analysis. Bivariable and multivariable logistic regressions were performed to identify factors associated with the level of health literacy. P-values less than 0.05 at 95% CI were used to declare statistically significant associations. The results were presented by text, tables and charts as necessary.

Results
From 634 total sample size about 604 participated. About 317 (52.5%) were males. The age of participants ranged from 14 to 19 years, with a mean age of 16.95+1.52. The finding revealed that only 35.26% (95% CI; 31.44, 39.09) of participants had desired health literacy, while 64.74% of them had limited health literacy levels. Age of 18–19 [AOR = 3.99(2.41, 6.60): p<0.001], being in 11–12 grade level [AOR = 2.38(1.44, 3.95); p = 0.001], being from currently employed father [AOR = 4.20(1.98, 8.92); p<0.001] and being from currently employed mother [AOR = 4.54(2.82, 7.31); p<0.001] were factors positively associated with the level of desired health literacy.

Conclusion
Since a significant number of students in our study area had limited health literacy, we recommend schools to integrate a school health service that contains health education services. Moreover, efforts should be undertaken to raise adolescent health literacy for middle adolescents, early adolescents, and students whose families were not employed.
The impact of divergent language policies on teachers’ language attitudes and proficiency in two multilingual education settings
Authors: Bier Ada , Lasagabaster David 
Published: December 2024

Abstract
This paper reports on a study on in-service and pre-service teachers’ language attitudes and perceived proficiency in two multilingual education contexts: the Basque Autonomous Community (Spain) and Friuli Venezia Giulia (Italy). The total sample was made up of 1,094 participants (553 pre-service teachers, 541 in-service teachers). Data were collected by means of the same questionnaire used in a study published in 2007, which this research replicates. The cross-country comparison highlights the impact of diverse language policies; the Basque Autonomous Community shows robust support for the minority language, Basque, in contrast to Friuli Venezia Giulia’s less supportive approach to Friulian. Similarities include teachers’ high perceived proficiency in the State language (Spanish and Italian respectively) and positive views on multilingualism (including the minority, the majority and English as a foreign language). Notably, in-service teachers express more favorable attitudes than their pre-service counterparts towards the minority language, but less favorable towards the State language. With this study, we aim to contribute to the ongoing discourse on multilingualism within an educational system that embraces multiple languages, aiming to provide potentially valuable insights for policy and teacher training practice.
Advanced titanium implants: combating corrosion and infection with cutting-edge coatings
Authors: Pantović Pavlović Marijana R. , Ignjatović Nenad L. , Gudić Senka , Bilušić Ante , Mladenović Dragana , Vrsalović Ladislav , Pavlović Miroslav M. 
Published: December 2024

Abstract
The presented research investigates the corrosion behavior of commercially pure titanium (cp-Ti) and amorphous calcium phosphate–chitosan (ACP@ChOL) coatings enriched with selenium on titanium in simulated body fluid (SBF). Using potentiodynamic polarization techniques, it was sought to derive essential corrosion parameters – corrosion potential, corrosion current density, breakdown potential, and passivation current. This study pioneers a comparative analysis of the corrosion stability of both samples. SEM/EDS analysis of surfaces pre- and postpotentiodynamic measurements offered insights into morphology and elemental composition. The aim was to elucidate the corrosion mechanism by integrating these techniques. Additionally, spontaneous corrosion behavior over 7 days, monitoring changes in open circuit potential, polarization resistance, and impedance were investigated. Furthermore, the antimicrobial efficacy of ACP@ChOL enriched with Se on titanium was assessed against Escherichia coli, Staphylococcus aureus, and Candida albicans, as well as in vitro release of Se. The presented study extends understanding, offering a unique perspective on the corrosion behavior and antimicrobial attributes of ACP@ChOL coatings enriched with Se on titanium. This composite material exhibits promise for medical applications, presenting an innovative avenue for addressing corrosion concerns and potentially reducing antibiotic reliance.
Galleys and gameboards: graffiti at the Prigione del Castello, Noto Antica, Sicily
Authors: Anthony Alexander W. , Hassam Stephan 
Published: December 2024

Abstract
The Central Mediterranean Penal Heritage Project (CMPHP) employs remote-sensing techniques to study and preserve archaeological remains of human confinement. Within this larger project, digital photogrammetry was used to document part of the castle prison in Noto Antica to identify and digitally preserve graffiti depicting galleys and gameboards.
S100A11 promotes lipid metabolism and activates the apoptosis in polycystic ovary syndrome
Authors: Yang Xiao , Li Muzi , Xu Zihan , Jiang Qi , Du Yanbo , Lv Hong , Yan Lei 
Published: December 2024

In briefAberrant lipid metabolism and dysregulated apoptosis in granulosa cells (GCs) may contribute to diminished ovarian reserve in patients with polycystic ovary syndrome (PCOS). This article elucidates the pivotal role played by S100A11.AbstractApoptosis of ovarian GCs affects the development and maturation of oocyte in PCOS. The objective of our study was to examine the impact of S100A11 on GCs in individuals with polycystic ovary syndrome. We found that the S100A11 level was higher in the ovarian GCs of PCOS patients and ovarian tissue of PCOS mouse models. S100A11 overexpression experiments demonstrated a decrease in the cell proliferation, upregulating the apoptosis and blocking the cell cycle. Immunofluorescence staining showed that S100A11 proteins were mainly located in the nucleus. Integrating the RNA-seq and ChIP-seq, this study found that S100A11 mainly regulated the genetic transcription and lipid metabolism. Furthermore, lipid accumulation and increasing oxidative stress were detected in the S100A11 overexpression group. We also revealed that S100A11 upregulated the p-DRP1 Ser616 to induce the mitochondrial fission. In conclusion, S100A11 upregulated the phospho-DRP1 to activate ovarian GC apoptosis and induced the lipid metabolism and oxidative stress to regulate the follicular reserve in PCOS. Our study provides a functional link between S100A11 expression and apoptosis and lipid metabolism in PCOS, providing new insights into disease mechanisms.
Loss of PRICKLE1 leads to subfertility, aberrant extracellular matrix and abnormal myometrial architecture in mice
Authors: Roberts Emily R , Ganeshkumar Sornakala , Gunewardena Sumedha , Chennathukuzhi Vargheese 
Published: December 2024

In briefPRICKLE1, a WNT/planar cell polarity (PCP) protein that is downregulated in uterine leiomyoma, plays an important role in myometrial tissue architecture and extracellular matrix (ECM) deposition. This paper shows that myometrial-specific ablation of the mouse Prickle1 gene results in a uterine leiomyoma phenotype.AbstractUterine leiomyomas (ULs) are the most prevalent benign tumors of the female reproductive tract, originating from the myometrium and affecting over 75% of reproductive-age women. Symptoms of UL include pelvic pain, pressure, dysmenorrhea, menorrhagia, anemia and reproductive dysfunction. Currently, there is no effective long-term pharmacotherapy for UL, making them the leading cause of hysterectomies in the United States. The lack of treatment options is attributed to the absence of accurate animal models and a limited understanding of UL pathogenesis. Previous research has shown that the loss of repressor of element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) within the myometrium promotes UL pathogenesis. In addition, deletion of Rest in the mouse myometrium leads to a UL phenotype. PRICKLE1, also known as Rest-interacting LIM-domain protein (RILP), is required for nuclear localization of REST and Wnt/PCP signaling, making it a critical target for UL studies. In the context of PCP, smooth muscle cells in UL show abnormal organization, aberrant ECM structure and expression levels, potentially influenced by PRICKLE1 loss. The exact role of PRICKLE1 and Wnt/PCP in UL pathogenesis remains unclear. To explore PRICKLE1’s role in UL, we deleted Prickle1 using our myometrial-specific iCre. Our findings demonstrate that Prickle1 loss in the myometrium results in a UL phenotype characterized by altered collagen expression, excessive ECM deposition, aberrant smooth muscle cell organization, increased Esr1 and Pgr expression and dysregulated Wnt/PCP signaling. This novel mouse model serves as a valuable preclinical tool for understanding UL pathogenesis and developing future pharmacotherapies.
An Evaluation of Quality of Life after Ventral Hernia Repair Using the EuraHS-QoL Score: a Cross-Sectional Survey
Authors: Prabhakar Harshit Kumar , Nair Vipin V , Pratap Pranay , Kumar Sarath , Bhalla Brig Alok 
Published: December 2024

Introduction. Recurrence rates for ventral hernia repairs are practically negligible because of advancements in surgical procedures. Pain and suffering, which significantly lowers patients’ quality of life, are currently the main concerns with ventral hernia repair rather than the possibility of recurrence. This study used “EuraHS-QoL” score for evaluating the quality of life of patients before and after ventral hernia repair. Methods. A prospective observational study involving patients with ventral hernias receiving surgery from May to December 2023. Using the EuraHS-QoL questionnaire, patients’ quality of life was evaluated both before and after surgery. Results. Of the 53 patients, 17 (32%) were men and 36 (68%) women, with a mean age of 49.71±10.9 years (range, 32–68 years). BMIs averaged 25.4±3.4 kg/m2, range (21.25 to 35.4 kg/m2). The majority of pain was from regular duties. By frequency, umbilical (22%), infraumbilical (43.3%), supraumbilical (5.7%), and numerous (19%) hernia sites exist. Three patients suffered surgery site infections and one had skin dehiscence. All patients showed overall improvement of QoL at the end of 90 days.
Relationship between Divorce and Well-being among Older Europeans
Authors: Rupšys Giedrius , Zamalijeva Olga , Kairys Antanas 
Published: December 2024

This study explores the relationship between divorce and well-being among older Europeans (50+), utilizing data from eight waves of the Survey on Health, Ageing and Retirement in Europe (SHARE). A quasi-experimental design was used to compare the well-being of divorced older adults before and after divorce with a control group of married individuals. CASP-12 scale was used to assess well-being. Results from a Linear Mixed Model reveal that divorced individuals tend to have lower well-being compared to their married counterparts, likely due to negative outcomes associated with divorce or preexisting lower well-being among those who choose to divorce. However, divorce is not associated with a change in well-being in the 2–3 year period surrounding divorce, potentially due to extended intervals between measurements or the absence of immediate effect of divorce.
Стиль життя в міждисциплінарному дискурсі
Authors: Фабер Денис 
Published: December 2024

Актуальність роботи. Стиль життя є складним і часто загальним поняттям, яке по-різному використовується та визначається в наукових дослідженнях. В даний час не існує єдиного визначення способу життя, і різні галузі знань розробили теорії та досліджують змінні, які також далекі одна від одної. Ця стаття є описовим оглядом літератури та аналізом концепції способу життя та її зв’язку з різними науками.
Мета статті – дослідження міждисциплінарних витоків поняття «Стиль життя» з врахуванням специфіки різних дослідницьких підходів, включаючи веберіанський підхід (економіка і суспільство), психологічний, медичний, маркетинговий, споживчий (соціологія,маркетинг, економіка), субкультурний (соціологія, культурологія) та філософський.
Результати. У статті розглядається концепція стилю життя з точки зору різних наукових дисциплін – психології, маркетингу, медицини, філософії, економіки, географії, соціології. Проведено порівняльний аналіз підходів до визначення стилю життя та його ролі в цих галузях знань.
Висновки. На основі цього огляду, можна визначити стиль життя як відмінну модель особистої та соціальної поведінки, характерну для окремої особи або групи. Поведінка включає дії, пов'язані зі стосунками з партнерами, родиною, друзями, сусідами, колегами, споживчу поведінку, дозвілля, роботу (оплачувану чи неоплачувану) та громадську діяльність. Патерни поведінки пов'язані з цінностями та соціально-демографічними характеристиками можуть включати різний ступінь соціальної взаємодії, узгодженості та впізнаваності, формуючись через процес широкого або обмеженого вибору.
Digitális kihívások: a technostressz megjelenése és kapcsolata a szervezeti pszichoszociális tényezőkkel magyar irodai munkavállalóknál
Authors: Simon Adél Csenge , Pachner Orsolya Csilla , Kiss Orhidea Edith 
Published: December 2024

Háttér és célkitűzések: A technostressz egy modern adaptációs betegség, amelyet a digitális újításokkal való megküzdés képtelensége okoz. Idesorolhatunk minden olyan munkahelyi stresszt, amely a digitális eszközök használatához kötődik. A technostressz jelenségét gyűjtőfogalomnak is tekinthetjük, amelyet tovább bonthatunk különböző alfaktorokra, ezek a techno-túlterhelés (techno-overload), techno-invázió (techno-invasion), techno-komplexitás (techno-complexity), techno-bizonytalanság (techno-insecurity), techno-kiszámíthatatlanság (techno-uncertainty). Számos kutatás foglalkozott az elmúlt néhány évben ezzel a jelenséggel, így mára biztosan tudjuk, hogy nagyban rontja a munkavállalók mentális egészségét, ami fiziológiai és pszichoszociális tüneteket egyaránt okozhat, valamint szervezeti problémák kiváltója is lehet. Ugyanakkor ez idáig nem született tanulmány, amely a magyar munkaerőpiacon vizsgálta volna a technostressz megjelenését és hatásait. Jelen kutatásunkban szerettük volna megvizsgálni a technostressz alfaktorai és a munkahelyi pszichoszociális tényezők közötti összefüggéseket. Módszer: Kutatásunkat online, anonim adatfelvétellel valósítottuk meg 2023 márciusa és áprilisa között. A mintába való bekerülés feltétele volt, hogy a kitöltő irodai munkát végezzen, legalább 2 év munkatapasztalattal rendelkezzen, valamint az utóbbi 3 évben munkaidejének egy részét home office munkavégzésben töltse. Összesen 462 fő (167 férfi és 295 nő) vett részt a vizsgálatunkban. Az adatelemzéshez a Technostress Creators Inventory és a Koppenhágai Kérdőív a Munkahelyi Pszichoszociális Tényezőkről II (COPSOQ II) változóit használtuk. Eredmények: Az adatelemzés során Spearman-korrelációt és többszörös lineáris regresszióanalízist végeztünk, amivel bizonyítottuk, hogy a technostressz alfaktorai nemcsak negatív összefüggést mutatnak a munkahelyi pszichoszociális tényezőkkel, hanem be is jósolják a változók alacsonyabb értékét. A többszörös lineáris regresszióval kapott modellek magyarázó ereje 4,8 és 23,1% között változott. Következtetések: A technostressz alfaktorai negatívan prediktálják a szervezeti pszichoszociális tényezőket, ezért fontos, hogy felhívjuk a magyar vezetők figyelmét a digitális átalakulással együtt járó egyéni, társas és szervezeti problémák hátterében meghúzódó faktorokra.
Single-parameter concrete carbonation model for varying environmental exposure conditions
Authors: Gopinath Rakesh , Alexander Mark , Beushausen Hans 
Published: December 2024

Abstract
Carbonation-induced reinforced steel concrete corrosion is a prominent concern related to engineering design and maintenance. The Durability Index (DI) approach was developed in South Africa to address this concern and enhance the durability performance of reinforced concrete structures. This approach relies on durability index tests, which are associated with transport mechanisms linked to specific deterioration processes. The carbonation of concrete is primarily influenced by the microstructure and transport characteristics of the concrete. Environmental exposure conditions also influence the rate of carbonation. The focus of the research reported here was to develop a carbonation model that could predict the rate of carbonation of concrete exposed to, or sheltered from, rain, with the permeability coefficient (k) from the Oxygen Permeability Index (OPI) test (DI test) as the key unifying variable. The model development was based on natural carbonation data and the drying profiles (experimentally measured) of 48 different concretes. Concrete microstructure was varied by varying the water-to-cement ratio, curing conditions, and by using SCMs. The resulting carbonation model was able to predict the rate of carbonation of concrete, allowing for different exposure conditions. A unique feature of this model is its use of a single material property, the 'k' value, to effectively address both CO2 diffusion and the drying process within concrete. The model displayed sensitivity towards the influence of variation in CO2 concentration, concrete microstructure, and the environmental exposure conditions, making this a simplified, effective and practical concrete carbonation prediction model.
McKie, Stuart. 2023. <em>Living and Cursing in the Roman West: Curse Tablets and Society</em>. London: Bloomsbury; 978-1-3502-8935-2 paperback £28.99.
Authors: Line Madeline 
Published: December 2024

This is a review of Living and Cursing in the Roman West: Curse Tablets and Society by Stuart McKie, published in 2023 by Bloomsbury.