bluuebunny/crossref_metadata_2025_split huggingface dataset:
STAGE OF DEVELOPMENT OF SYSTEM APPROACH OF DESIGNING
Authors: Barysheva V. , Druzhinina O. 
Published: December 2020

In this paper the stages of development of system approach of designing in different countries, including Russia. Authors study the genesis of this phenomenon of design-culture from XX century (the moment of formation of industrial design as a professional activity) up to its theoretical and methodological foundation by materials of Soviet specialists from the All-Union Scientific Research Institute of Technical Aesthetics (VNIITE) in the 1960-1980s.
Each stage of the development of a system approach was analyzed taking into account the sociocultural and economic background. The article was focused on the sources of the formation of a system approach in design as a methodology in Russian design practice such as the «Interdesign» seminars, research works carried out in the VNIITE and higher educational institutions, as well as the results of the practical application of the system approach of design in the works of the Institute and its branches.
Inhibition of Lysyl Oxidase with β-aminopropionitrile Improves Venous Adaptation after Arteriovenous Fistula Creation
Authors: Hernandez Diana R. , Applewhite Brandon , Martinez Laisel , Laurito Tyler , Tabbara Marwan , Rojas Miguel G. , Wei Yuntao , Selman Guillermo , Knysheva Marina , Velazquez Omaida C. , Salman Loay H. , Andreopoulos Fotios M. , Shiu Yan-Ting , Vazquez-Padron Roberto I. 
Published: December 2020

Background
The arteriovenous fistula (AVF) is the preferred hemodialysis access for patients with ESKD. Yet, establishment of a functional AVF presents a challenge, even for the most experienced surgeons, because postoperative stenosis frequently occludes the AVF. Stenosis results from the loss of compliance in fibrotic areas of the fistula, which turns intimal hyperplasia into an occlusive feature. Fibrotic remodeling depends on deposition and crosslinking of collagen by lysyl oxidase (LOX), an enzyme that catalyzes the deamination of lysine and hydroxylysine residues, facilitating intra/intermolecular covalent bonds. We postulate that pharmacologic inhibition of LOX increases postoperative venous compliance and prevents stenosis in a rat AVF model.

Methods
LOX gene expression and vascular localization were assayed in rat AVFs and human preaccess veins, respectively. Collagen crosslinking was measured in humans AVFs that matured or failed, and in rat AVFs treated with β-aminopropionitrile (BAPN), an irreversible LOX inhibitor. BAPN was either injected systemically or delivered locally around rat AVFs using nanofiber scaffolds. The major endpoints were AVF blood flow, wall fibrosis, collagen crosslinking, and vascular distensibility.

Results
Nonmaturation of human AVFs was associated with higher LOX deposition in preaccess veins (n=20, P=0.03), and increased trivalent crosslinks (n=18, P=0.03) in human AVF tissues. Systemic and local inhibition of LOX increased AVF distensibility, while reducing wall fibrosis and collagen crosslinking in rat fistulas.

Conclusions
Our results demonstrate that BAPN-mediated inhibition of LOX significantly improves vascular remodeling in experimental fistulas.
“Τί ὅτι συνεφωνήθη ὑμῖν…” Implicancias comunitarias y domésticas en el episodio de Ananías y Safira (Hch 5.1-11)
Authors: Spléndido Mariano Agustín 
Published: December 2020

Uno de los episodios más extraños de Hechos de los Apóstoles es el relativo a Ananías y Safira, creyentes que mueren súbitamente por defraudar a la iglesia con el importe de una donación. Nuestro objetivo será comprender este relato como parte de la reflexión del autor sobre el liderazgo carismático e itinerante, resistido hacia fines del siglo I por nuevas autoridades locales con base doméstica. Mientras Hch reivindica el poder de los apóstoles-profetas, otros escritos contemporáneos como Didache están reclamando que la comunidad ponga a prueba a los maestros carismáticos y se refugie en los líderes locales.
Ultrasound and management strategies in chronic pain
Authors: Hidayati Hanik Badriyah 
Published: December 2020

Pain is the most common reason for seeking medical advice. Chronic pain remains a significant major problem. Imaging techniques are essential tools in interventional pain management (IPM). Ultrasound (US) has been comparatively a recent technology and its wider use has and an increased interest in imaging in IPM. This editorial briefly introduces the application of the US in chronic pain management strategies, and highlights its application, benefits, evidence and limitations in IPM.
Keywords: Chronic pain; Interventional pain management; Ultrasound; Imaging
Citation: Hidayati HB. Ultrasound and management strategies in chronic pain. Anaesth. pain intensive care 2020;24(6):__
Received: 15 September 2020, Reviewed: 26 September 2020, Accepted: 15 November 2020
Modified thoracolumbar interfascial plane block versus epidural analgesia at closure for lumbar discectomy: a randomized prospective study
Authors: ÇELIK Erkan Cem , EKINCI Mursel , YAYIK Ahmet Murat , AHISKALIOGLU Ali , AYDI Muhammed Enes , KARAAVCI Nuh Cagri 
Published: December 2020

Background & objective: The postoperative period of lumbar discectomy surgery usually involves a period of moderate to severe pain if adequate pain management is not practiced. Various pain controlling methods have been used other than oral and/or parenteral analgesic administration. We aimed to examine the effect of epidural analgesia at closure (EAC) versus modified thoracolumbar interfascial plane (mTLIP) block on postoperative opioid consumption in patients undergoing lumbar discectomy.
Methodology: It was a randomized, prospective study involving sixty adult patients undergoing single-level lumbar discectomy. Patients were randomly assigned to two groups. mTLIP group (n=30) received ultrasound-guided bilateral mTLIP block with 20 ml of 0.25% bupivacaine. EAC group (n=30) received 20 ml of 0.25% bupivacaine to the epidural space by the surgical team at the closure stage of surgery. Postoperatively, analgesia was performed with intravenous tramadol with a patient-controlled analgesia (PCA) pump. Visual analog scale (VAS) scores, opioid consumption, rescue analgesia and side effects were recorded.
Results: Groups had similar demographic measures. There was statistically no difference in terms of opioid consumption from zero to 4th hr and VAS scores in the 1-2 hrs postoperatively (p > 0.05) between groups. At 4-12 hrs and 12-24 postoperatively hrs intervals, total opioid consumption was significantly lower in Group mTLIP compared to Group EAC (p < 0.05). At the 4th, 8th, 12th, and 24th hrs VAS scores were lower in Group mTLIP compared to Group EAC (p < 0.05). Rescue analgesia usage was significantly higher in the Group EAC than in the Group mTLIP, e.g. 11/30 vs. 3/30 respectively (p = 0.015).
Conclusion: Preoperative bilateral, ultrasound-guided modified thoracolumbar interfascial plane block offers more effective postoperative analgesia, thus reducing tramadol consumption as compared to epidural analgesia at closure after lumbar discectomy surgery.
Key words: Thoracolumbar interfascial plane block; Epidural analgesia’; Lumbar discectomy; Postoperative pain; Ultrasound guidance
Citation: Çelik EC, Ekinci M, Yayik AM, Ahiskalioglu A, Aydi ME, Karaavci NC. Modified thoracolumbar interfascial plane block versus epidural analgesia at closure for lumbar discectomy: a randomized prospective study. Anaesth. pain intensive care 2020;24(6):__
Abbreviations: EAC – Epidural analgesia at closure; TLIP – thoracolumbar interfascial plane; mTLIP – modified thoracolumbar interfascial plane
Brig Professor Zafar Ahmed Malik
Authors: Salim Brig (R) Muhammad 
Published: December 2020

Zafar Ahmed Malik was born on 20th March, 1937, he spent his early years in Talagang, a small town near Rawalpindi. He completed his matriculation from Talagang High School and the interesting aspect was that all of his teachers were matric fail with the exception of one. He completed his MBBS from the University of Peshawar in 1962, and joined the army service. He qualified MCPS on 16th February 1968, and FCPS (Anesthesiology) on 9th February 1974. He then went to Ireland where he did his FFARCS(I) in 1976 from the Royal College of Surgeons. During his Army service he participated in the 1965 and 1971 wars with India; and was awarded with Tamgha-i-Jand and Sitara-i-Harb for his selfless and fearless services.
IDENTIFICATION LOCAL ISOLATES OF Trichophyton mentagrophytes AND DETECTION OF KERATINASE GENE USING PCR TECHNIQUE
Authors: & et al. Abbas 
Published: December 2020

This study was aimed to identify dermatophytic selective isolate using PCR technique as a rapid molecular assay. The results of this study showed among 60 samples of patients suffering from ringworm disease. forty isolates (66%) were Trichophyton mentagrophytes which diagnosed as dermatophytosis according to morphological and cultural methods. In order to investigate the ability of isolates to keratin analyses using solid medium supplemented with keratin azure , the results revealed that 20 isolates appeared best ability to keratin analysis and nine isolates had best ability for keratinase production in submerged culture. According to this results T. mantagrophytes (K3) (had higher activity for keratinase) was chosen for molecular identification. The results of PCR revealed that primer for18S rRNA gene of T. mentagrophytes K1 isolate and specific primer for subtilisin like protease gene were amplified and appeared as single DNA band with a molecular base of 690 bp and 623bp respectively .The blast result of sample sequences of amplified fragment revealed that the isolate were 100% identical to reference sequence of T.mentagrophytes var. interdigtal and depending on data base in NCBI The result of PCR product for enzyme showed new type named GBF60362 (402) subtilisin-like protease related to T. mentagrophytes 1354684064 BFBSOLP00892.
EXTENSION ACTIVITIES PROVIDED TO RICE FARMERS IN RAISING THE AWARENESS FOR COMPOST MANUFACTURE IN AL-DIWANIYAH PROVINCE
Authors: Al-Salhi A. T. 
Published: December 2020

This study was aimed to determine extension activities provided to rice farmers in raising the awareness for compost manufacture in Al-Diwaniyah province and investigate the level of awareness of rice farmers in the field of compost manufacturing , as well as the problems facing farmers when manufacturing compost, mythology a questionnaire design to collect data from rice farmers during the 2018 . The research society consisted of the agricultural departments of the directorate of Agriculture in Al Diwaniyah province. A random sample was taken from rice farmers related to the agricultural departments in the Directorate of Agriculture with their (632) farmers, The results of this study inculcated that the level of awareness for the farmers in the manufacture of compost, The average tends to weak in their awareness, The role of the agricultural extension has also just through extension seminars, which is considered one of the most extension activities were used to rice farmers of compost manufacturing, In addition, there is an absence of workers in the field of composting of rice residues,It could be to pay adequate attention to the rice crop as a strategic crop through the utilization of its waste and the elimination of environmental pollution that occurs as a result of burning those waste.
Do Multidisciplinary Tumor Board Discussions Correlate With Increase in 5-Year Survival? A Meta-Analysis Study
Authors: Algwaiz Ghada , Salam Yezan , Bustami Rami , Ferwana Mazen , Jazieh Abdul Rahman 
Published: December 2020

ABSTRACT

Introduction
Due to the complex nature of cancer cases, it is imperative that the involved healthcare providers coordinate the patients care plan in union to reach the best possible outcome in the smoothest and fastest manner. This is what multidisciplinary tumor board (MTB) meetings strive to achieve. Conducting regular MTB meetings requires significant investment of time and finances. It is thus vital to assess the empirical benefits of such practice.

Methods
A meta-analysis was conducted to evaluate the literature regarding the impact of MTB meetings on patient 5-year survival. Relevant studies were identified by searching Ovid MEDLINE and Embase databases from January 1995 to July 2019. Studies were included if they assessed 5-year survival in cases discussed in MTB meetings and used a comparison group and/or a pretest and posttest design.

Results
Five articles met the study's inclusion criteria. Quality of studies was affected by selection bias and the use of historic cohorts. The results showed significantly improved 5-year survival in the MTB group compared with the non-MTB groups (odds ratio for 5-year death rate of 0.59, CI 0.45–0.78, p &lt; 0.001).

Conclusion
This meta-analysis showed that cancer MTB meetings have a significant impact on patients' 5-year survival. This could be because of several reasons, such as less time to treatment initiation, better adherence to guidelines, higher numbers of investigational imaging, lesser surgical complications, and recurrence rates. Future prospective studies are needed to further delineate reasons for improvement of outcome to enhance the benefits of this approach.
CREATIVE AND INNOVATIVE PROBLEM SOLVING (CIPS) DALAM PEMBELAJARAN MATEMATIKA BERBASIS MNR (MATEMATIKA NALARIA REALISTIK)
Authors: Pebriani Linda , Wulandari Dwi , Setiani Rahyu , Nur Afifah Dian Septi 
Published: December 2020

Permasalahan matematika sangat beragam baik dari segi siswa, guru, metode belajar, gaya belajar, maupun pemecahan masalah. Pemecahan masalah merupakan hal yang menjadi aktivitas pokok dan metode berpikir dalam menyelesaikan masalah menjadi hal yang penting untuk dilakukan. Permasalahan matematika yang diselesaikan berdasarkan nalar dan logika sehingga memunculkan berbagai solusi pemecahan yang bervariasi disebut dengan Matematika Nalaria Realistik (MNR). MNR merupakan sebuah metode yang dapat diterapkan dalam pembelajaran, sehingga nantinya dari hasil pengerjaan siswa dapat diketahui kreativitas serta inovasi siswa dalam menyelesaikan permasalahan matematika. Kreativitas dan Inovasi dalam pemecahan masalah bisa disebut dengan Creative and Innovative Problem Solving (CIPS) yaitu sebuah proses pemecahan masalah dengan mengembangkan daya berfikir siswa yang meliputi klarifikasi masalah, pengungkapan pendapat, membangun pengetahuan, evaluasi dan pemilihan strategi, serta implementasi. Penelitian ini dilakukan guna meningkatkan kemampuan siswa dalam memecahkan berbagai permasalahan dan persoalan matematika yang selama ini dianggap sulit oleh mayoritas siswa. Berdasarkan penelitian studi literatur yang dilakukan maka dapat disimpulkan bahwa langkah-langkah MNR yang diterapkan dalam pembelajaran dapat menumbuhkan CIPS.
SUBSTANTIATION OF APPROPRIATE OPTIONS FOR APPLICATION OF METHODS OF OBSERVABILITY ATTENUATION OF UKRAINIAN ARMED FORCES’ MILITARY EQUIPMENT, PROTECTION OF PERSONNEL AND EQUIPMENT FROM TECHNICAL MEANS OF RADIOLOCATING AND OPTICAL-ELECTRONIC INTELLIGENCE
Authors: Zhivetc Y. , Yermolenko O. , Koval V. 
Published: December 2020

Development of technologies for creating materials, environments and coatings with specified electrophysical characteristics for practical implementation in production and widespread use of observability attenuation technologies of surface, air, space, abovewater objects, surface-based installations, troops for the needs of Armed Forces of Ukraine and other military formations, impacts of artificial sources of electromagnetic radiation on the human body today is especially relevant.
Nowadays, "stealth technologies" include the following main areas: the theory of diffraction on bodies of complex shape, research and development of radio-absorbing materials, coating technology and, finally, radiophysical experiment, which is used for control in each of these areas. One of the most important tasks is to reduce the level of signals generated by the reflection of electromagnetic waves emitted by radars, since radars still remain the most "long-range" means of detecting targets and air defense systems aiming.
To date, "stealth technology" begins with mathematical modeling of electromagnetic wave scattering on an object, the radar visibility of which should be reduced. This step is essential for a preliminary assessment of the possible result and allows optimizing the shape and electrophysical characteristics of the object.
The world leading countries have developed absorbing materials that capable to provide electromagnetic compatibility of the electronic equipment, camouflaging and counteraction to radio technical intelligence, use in designs of the radio electronic equipment.
The comparative analysis of the developings that are promising for usage as radio-absorbing materials and radio-absorbing covering is carried out in the work.
In the future, it is planned to expand the shielding frequency range and the range of use of absorbing coatings to protect personnel and equipment from electromagnetic emission.
Updated Measurements of Proton, Electron, and Oxygen Temperatures in the Fast Solar Wind
Authors: Cranmer Steven R. 
Published: December 2020

Abstract
The high-speed solar wind is typically the simplest and least stochastic type of large-scale plasma flow in the heliosphere. For much of the solar cycle, it is connected magnetically to large polar coronal holes on the Sun’s surface. Because these features are relatively well-known (and less complex than the multiple source-regions of the slow wind), the fast wind is often a useful testing-ground for theoretical models of coronal heating. In order to provide global empirical constraints to these models, here we collect together some older and more recent measurements of the temperatures of protons, electrons, and oxygen ions as a function of radial distance.
Situação de estudo e abordagem temática: análises sobre as escolhas dos temas
Authors: Marques da Silva Josiane , Flores Magoga Thiago , Muenchen Cristiane 
Published: December 2020

Neste estudo são discutidos os processos de escolhas de temas no contexto das perspectivas de reorganização curricular da Abordagem Temática e da Situação de Estudo, por meio de uma revisão bibliográfica em trabalhos publicados nas atas do Encontro Nacional de Pesquisas em Educação em Ciências (ENPEC), no período de 1997 até 2017. Desta forma, este trabalho preocupa-se em responder o seguinte questionamento: Como os temas vêm sendo definidos em práticas educativas baseadas na Situação de Estudo, em comparação à Abordagem Temática? Metodologicamente de cunho qualitativo, a análise dos trabalhos selecionados foi orientada pelos pressupostos da Análise Textual Discursiva emergindo, assim, duas categorias analíticas (i) Vivências cotidianas como balizadoras das escolhas e ii) Distintos parâmetros de escolhas. Sinaliza-se, com isso, a aparente distinção nas interpretações dos elementos da tríade sujeito – contexto – conhecimento científico para a escolhas e abordagem dos temas no âmbito das perspectivas curriculares Situação de Estudo e Abordagem Temática.
Enhanced Immunotherapeutic Efficacy of Anti–PD-L1 Antibody in Combination with an EP4 Antagonist
Authors: Sajiki Yamato , Konnai Satoru , Cai Zimeng , Takada Kensuke , Okagawa Tomohiro , Maekawa Naoya , Fujisawa Sotaro , Kato Yukinari , Suzuki Yasuhiko , Murata Shiro , Ohashi Kazuhiko 
Published: December 2020

Abstract
Combination treatment approaches are increasingly considered to overcome resistance to immunotherapy targeting immunoinhibitory molecules such as programmed death (PD)–1 and PD-ligand 1 (PD-L1). Previous studies have demonstrated that the therapeutic efficacy of anti–PD-L1 Abs is enhanced by combination treatment with cyclooxygenase-2 inhibitors, through downregulation of the immunosuppressive eicosanoid PGE2, although the underlying mechanism remains unclear. In this study, we show that serum PGE2 levels are upregulated after anti–PD-L1 Ab administration in a bovine model of immunotherapy and that PGE2 directly inhibits T cell activation via its receptor E prostanoid (EP) 4. Additionally, anti–PD-L1 Ab induces TNF-α production and TNF-α blockade reduces PGE2 production in the presence of anti–PD-L1 Ab, suggesting that anti–PD-L1 Ab–induced TNF-α impairs T cell activation by PGE2 upregulation. Our studies examining the therapeutic potential of the dual blockade of PD-L1 and EP4 in bovine and murine immune cells reveal that the dual blockade of PD-L1 and EP4 significantly enhances Th1 cytokine production in vitro. Finally, we show that the dual blockade decreases tumor volume and prolongs survival in mice inoculated with the murine lymphoma cell line EG7. Altogether, these results suggest that TNF-α induced by anti–PD-L1 Ab treatment is associated with T cell dysfunction via PGE2/EP4 pathway and that the dual blockade of PD-L1 and EP4 should be considered as a novel immunotherapy for cancer.
Acute Lipopolysaccharide-Induced Inflammation Lowers IL-2R Signaling and the Proliferative Potential of Regulatory T Cells
Authors: Hsiung Sunnie , Moro Alejandro , Ban Yuguang , Chen Xi , Savio Alicia Santos , Hernandez Rosmely , Malek Thomas R 
Published: December 2020

Abstract
IL-2R signaling is essential for the development and homeostasis of CD4+Foxp3+ regulatory T cells (Tregs). Low-dose IL-2 is being advanced as a therapy for autoimmune diseases because of its ability to expand Tregs. Although Treg stability and function is diminished by chronic inflammation, the impact of inflammation on proximal IL-2R signaling and/or responsiveness to low-dose IL-2 is poorly understood. In this study, we show that acute inflammation induced by LPS, analogous to responses to acute bacterial infection, led to decreased endogenous STAT5 signaling and proliferative potential as measured by Ki67 in mouse Tregs. This impaired Treg activity was transient, did not lead to a reduction in Treg numbers or function, and was due to TLR signaling by non-Tregs. Although acute LPS induced high levels of IL-1 and IL-6, these cytokines did not solely mediate dysregulated Treg activity. Global gene expression analyses demonstrated that acute LPS-induced inflammation substantially and rapidly altered the Treg transcriptome. In the presence of an IL-2R agonist, the mouse IL-2/CD25 fusion protein (mIL-2/CD25), this type of inflammatory response tempered the transcription of IL-2R–dependent genes in vivo. Gene enrichment and pathway analyses are consistent with LPS attenuating mIL-2/CD25–dependent genes related to the cell cycle, DNA replication, and cholesterol biosynthesis while enhancing mRNAs that mediated Treg suppression in vivo. Acute LPS-induced inflammation diminished some responses by Tregs to mIL-2/CD25 treatment in vivo. Together, these results suggest a role for persistent IL-2R signaling in mitigating some but not all of the deleterious effects of inflammation on Treg proliferation while supporting their function.
MỘT THUẬT TOÁN HIỆU QUẢ CHO BÀI TOÁN KHAI THÁC MẪU TUẦN TỰ VỚI RÀNG BUỘC TRỌNG SỐ
Authors: THỊ THIẾT PHẠM 
Published: December 2020

Khai thác mẫu tuần tự có trọng số giúp tìm ra các mẫu có giá trị cao hơn nên có thể được áp dụng trong nhiều lĩnh vực hơn đồng thời giải quyết một số khó khăn về không gian lưu trữ và tài nguyên thực hiện trong bài toán khai thác mẫu tuần tự với độ hỗ trợ min_sup thấp. Bài báo đề xuất một tiếp cận mới trong khai thác mẫu tuần tự có trọng số bằng việc kết hợp giá trị trọng số thực của các item trong cơ sở dữ liệu chuỗi cùng với độ hỗ trợ của chúng để tìm ra tập mẫu phổ biến có giá trị hơn. Hơn nữa, thuật toán đề xuất sử dụng phương pháp tiếp cận dữ liệu theo chiều dọc nên thuật toán chỉ cần duyệt cơ sỡ dữ liệu một lần, do đó tiết kiệm được thời gian thực thi. Bên cạnh đó, để tăng hiệu suất tính toán, thuật toán áp dụng mã hóa khối nguyên tố trong các bước tính toán của quá trình phát triển mẫu. Kết quả thực nghiệm cho thấy thuật toán đề xuất có thời gian thực thi hiệu quả hơn.