bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Budaya Organisasi dan Motivasi Terhadap Kinerja Guru Madrasah
Authors: Kosim Nanang 
Published: January 2021

Penelitian ini bertujuan untuk mengungkap pengaruh budaya organisasi dan motivasi terhadap kinerja guru madrasah aliyah (MA) se-Kecamatan Tungkal Jaya Kabupaten Musi Banyuasin (MUBA). Penelitian dilakukan dengan pendekatan kuantitatif dengan metode survey. Adapun teknik yang digunakan untuk mencari dan mengumpulkan data, adalah dengan menggunakan instrumen berupa angket. Populasi yang ada adalah 59 orang, terdiri dari 32 orang bertugas pokok sebagai tenaga pendidik dan 27 orang bertugas pokok sebagai tenaga kependidikan. Oleh karena penelitian ini untuk mengungkap berkaitan dengan kinerja guru, maka yang dijadikan sampel adalah mereka yang memiliki tugas pokok sebagai tenaga pendidik, dan dalam hal ini sampel ditetapkan hanya 32 orang. Setelah angket disebar dan dikumpulan dari 32 guru (responden), hasilnya selanjutnya dianalisis menggunakan rumus regresi linier berganda dengan bantuan SPSS versi 11.5. Hasil analisis berkaitan dengan keadaan budaya organisasi, motivasi maupun kinerja guru yang ada di MA. se-Kecamatan Tungkal Jaya Kabupaten Musi Banyuasin, ketiga-tiganya berada pada kategori cukup baik dengan presentasi 66%, 69%, 66%. Kemudian berdasarkan hasil out put pada tabel anova, hasil uji f menunjukkan bahwa budaya organisasi dan motivasi secara bersama-sama berpengaruh signifikan terhadap kinerja guru MA se-Kecamatan Tungkal Jaya Kabupaten MUBA. Hal tersebut didasarkan kepada nilai (28.082) > (3.32). Demikian pula dengan nilai sig (0.000) yang lebih kecil dari nilai 0.05.
Penelitian ini bertujuan untuk mengungkap pengaruh budaya organisasi dan motivasi terhadap kinerja guru madrasah aliyah (MA) se-Kecamatan Tungkal Jaya Kabupaten Musi Banyuasin (MUBA). Penelitian dilakukan dengan pendekatan kuantitatif dengan metode survey. Adapun teknik yang digunakan untuk mencari dan mengumpulkan data, adalah dengan menggunakan instrumen berupa angket. Populasi yang ada adalah 59 orang, terdiri dari 32 orang bertugas pokok sebagai tenaga pendidik dan 27 orang bertugas pokok sebagai tenaga kependidikan. Oleh karena penelitian ini untuk mengungkap berkaitan dengan kinerja guru, maka yang dijadikan sampel adalah mereka yang memiliki tugas pokok sebagai tenaga pendidik, dan dalam hal ini sampel ditetapkan hanya 32 orang. Setelah angket disebar dan dikumpulan dari 32 guru (responden), hasilnya selanjutnya dianalisis menggunakan rumus regresi linier berganda dengan bantuan SPSS versi 11.5. Hasil analisis berkaitan dengan keadaan budaya organisasi, motivasi maupun kinerja guru yang ada di MA. se-Kecamatan Tungkal Jaya Kabupaten Musi Banyuasin, ketiga-tiganya berada pada kategori cukup baik dengan presentasi 66%, 69%, 66%. Kemudian berdasarkan hasil out put pada tabel anova, hasil uji f menunjukkan bahwa budaya organisasi dan motivasi secara bersama-sama berpengaruh signifikan terhadap kinerja guru MA se-Kecamatan Tungkal Jaya Kabupaten MUBA. Hal tersebut didasarkan kepada nilai (28.082) > (3.32). Demikian pula dengan nilai sig (0.000) yang lebih kecil dari nilai 0.05.
Teaching the Social Determinants of Health Through Medical Legal Partnerships: A Systematic Review
Authors: Robinson Benjamin , Welch Kristian , Martin Michaela , Salerno Amy , Harris Drew 
Published: January 2021

Abstract
Background: Medical education is increasingly focused on the social determinants of health (SDoH), but questions remain regarding how best to ensure that trainees become empowered to take action on the SDoH in their future practice. The authors conducted a systematic review to better define the impact that educational programs centered on medical legal partnerships (MLP) have on trainees’ knowledge, attitudes and future practice. Methods: The authors sourced data from PubMed, Web of Science, Index to Legal Periodicals, LegalTrac, Google Scholar, Academic Search Complete, Business Source Complete, SocINDEX, SSRN, and Proquest Social Sciences. Selected studies included those centered on Medical Legal Partnerships in graduate medical education and that measured outcomes of the participating trainees. Two abstractors independently extracted information about the study population, setting, design, intervention and outcomes. The literature search was conducted in 2019. Results: Six out of 483 studies met the inclusion criteria. One study highlighted three different MLPs, thus eight total MLP programs were included. Trainees included residents from pediatrics, family medicine and internal medicine. Interventions ranged from didactic sessions, to advocacy projects, to hands-on community-based learning, to poverty simulation trainings. Benefits to trainees were wide in scope but all programs showed improvements in participants’ understanding, comfort, confidence, and/or abilities in identifying and intervening on SDoH in their patients. Conclusion: As undergraduate and graduate medical education is increasingly considering how to effectively teach trainees to understand and address SDoH, the findings in this systemic review suggest that inclusion of Medical-Legal Partnerships into training programs is an effective approach.
Identification and Characterization of The Pyruvate Dehydrogenase E1 Gene in The Oriental River Prawn, Macrobrachium Nipponense
Authors: Jin Shubo , Hu Yuning , Fu Hongtuo , Jiang Sufei , Xiong Yiwei , Qiao Hui , Zhang Wenyi , Gong Yongsheng , Wu Yan 
Published: January 2021

Abstract
Pyruvate dehydrogenase E1 (PDHE1) was predicted to be involved in the male sexual development in M. nipponense in the previous study. In this study, the functions of Mn-PDHE1 were further analysed in depth using quantitative polymerase chain reaction (qPCR), in situ hybridization, western-blot and RNA interference (RNAi), combined with the histological observations. The full-genome sequence of Mn- PDHE1 was 65,630 base pairs (bp) on Chromosome 11, including 15 introns and 14 exons. The full cDNA sequence of Mn-PDHE1 was 1614 bp, including a 1077 bp open reading frame, encoding for 358 amino acids. qPCR analysis revealed that Mn- PDHE1 showed the highest expression level in the testis, and male prawns at post-larval developmental stage 25 (PL25♂) was higher than PL25♀, indicating that PDHE1 was potentially involved in the male sexual development in M. nipponense. An additional function of Mn-PDHE1 was predicted to be involved in the metamorphosis process. In situ hybridization and western-blot indicated that PDHE1 was involved in the whole testis development. The Mn-IAG mRNA was decreased with the decrease of Mn- PDHE1. This indicated PDHE1 has the positive regulatory effects on IAG in M. nipponese. The testis and androgenic gland development were delayed after the injection of Mn- PDHE1 dsRNA, compared with those of control group, indicating PDHE1 has positive effects on the male sexual development in M. nipponense. This study highlights the functions of PDHE1 in M. nipponense, which can be applied to future studies of the male sexual development in other crustacean species.
Data Mining on Some Factors Related to the Stillbirth of Mothers Referred to Health Centers in Some Provinces of Iran
Authors: Rahmati Nazanin , Kamalgharibi Hadiseh , hosseini Mohammad Mehdi , Jalali Alireza 
Published: January 2021

Abstract
Purpose This study aimed to determine the relationship between maternal risk factors and stillbirth in some provinces. In the field of health, databases contain a wide range of public health variables. The purpose of this article is to explore the concepts related to data mining and its application in the field of health.Methods This study is a case-control. The study population consisted of 3340 mothers who referred to health centers of some provinces of the country in 2016. The 1459 mothers had a history of stillbirth and 1881 of them had a live birth at the last pregnancy. Then, data mining algorithms were used to investigate the desired data.Results Number Abortion, Mo Blood Group, Number Live Birth, Parity pregnancy, tanesh life, Mo Age ,Neonate weight, Smoking during pregnancy, Mo Educate, Number Death Neonate, Job Number, City Number, and Type Delivery Maternal risk factors are stillbirths. The accuracy of Naïve Bayes 82.71%, Logistic Regression 87.42%, Deep Learning 86.06%, Decision Tree 87%, Gradient Boosted 84.49%, Svm 86.79%.Conclusion This study supports the hypothesis that Factors affecting stillbirth in some algorithms are somewhat identical and in others different and that different preventive and treatment strategies might be required. The overall conclusion of this study shows that Logistic Regression models and Decision Tree are the most suitable models for prediction (classification) Stillbirth mothers (among the models investigated in this study). On the most important predictors, variables NumberAboration, Paritypregnancy, taneshlife, NumberDeathNeonate, City Number are presented as the most critical predictors in this study.
Designing A Candidate Multi-Epitope Vaccine Against SARS-CoV-2 Using Reverse Vaccinology Approach
Authors: Atapour Amir , Golestan Ali 
Published: January 2021

Abstract
Coronavirus 2019 (COVID-19) infection is a global epidemic that is spreading dramatically from day today. Currently, many efforts have been made against COVID-19 through the designing or developing of specific vaccines or drugs, worldwide. Unfortunately, to date, it has not been successful. Therefore, an effective vaccine against COVID-19 is mandatory. In this study, we used the bioinformatics approach to design an effective multi-epitope vaccine against COVID-19 based on Spike protein. Here, we implemented in silico tools to identify potential T and B cell epitopes that can induce cellular and humoral immunity. Then, the peptide sequence of potential T, B cell epitopes, and flagellin (as an adjuvant molecule) was joined together by suitable linkers to construct of candidate multi-epitope vaccine (MEV). Subsequently, immunological and structural evaluations such as antigenicity, 3D modeling, etc. were performed. In the following, molecular docking of vaccine constructs with Toll-Like Receptors 5 (TLR5), Molecular Dynamics (MD) simulation as well as in silico cloning were carried out. Immunological and structural computational data showed that designed MEV potentially has proper capacity for inducing cellular and humoral immune responses against COVID-19. Based on the preliminary results, in vitro and in vivo experiments are required for validation in the future.
Keywords: COVID-19, Vaccine, Reverse Vaccinology, Multi-epitope, Molecular docking, MD Simulation.
Temporal Analysis for Multi-hazard Risk Assessment of Rice Cultivation in Coastal Areas: A Case Study of Soc Trang, Vietnam
Authors: Vo Thanh Quoc , Nguyen Trung Hieu , Linh Vo Thi Phuong 
Published: January 2021

Abstract
Rice is an important human crop and rice cultivation is threatened due to natural disasters, leading to negative effects on national and global food security. The natural disasters, such as tropical cyclones and saline intrusion, have dramatic influences in coastal regions. To investigate possible impacts of these disasters on rice cultivation, it needs an efficient tool to assess potential disasters impacts and a risk index is highly applicable. Therefore, this study aims at establishing a risk assessment of rice production in coastal areas under effects of tropical cyclones and saline intrusion. We adopted risk definition introduced by IPCC (2014) in which risk is a function of hazard, exposure and vulnerability. Multiple hazards of tropical cyclones and saline intrusion were indicated by their frequency and severity at some critical levels of 25%, 50% and >50% rice yield reduction. Each hazard was weighted by its damage on rice yield. Exposure and vulnerability of rice crops are evaluated at different growing phases. Tropical cyclone hazard index was ranked high and very high in the wet season while salinity hazard index was ranked very high in the dry season. Due to the combined effects of tropical cyclones and salinity, rice crop is highly susceptible during the reproduction phase and at the panicle initiation stage particularly. Based on the cropping calendar of My Xuyen, the period of October-November was the very high vulnerability period since it had the largest rice cultivable area and rice crops were at the reproduction phase. This result shows that rice crops are at high risk in October and November. Noticeably, saline intrusion reaches the highest level in April and May, but no risk is at this period because of no rice crop cultivated. This can reflect a measure to reduce risk by adjusting the cropping calendar.
Cost-effectiveness Analysis of Rituximab Associated With Fludarabine and Cyclophosphamide (R-FC) for the First-line Treatment of Chronic Lymphocytic Leukemia Under the Brazilian Public Health System (SUS).
Authors: Azevedo Bruno , Carvalho Adriana , Sasse Andre Deeke 
Published: January 2021

Abstract
BACKGROUNDChronic Lymphocytic leukemia is the most common leukemia in the western world. In the last decade, treatment options expanded with an expressive rise in treatment costs. In Brazil the overall cancer treatment costs are rising mainly due to the judicialization law suits. The efficacy and safety of associating rituximab to fludarabine and cyclophosphamide (R-FC) for the treatment of chronic lymphocytic leukemia has been demonstrated by the CLL8 trial, which was conducted in previously untreated patients positioning the immunochemotherapy regimen as the standard choice for physically fit patients. Considering this scenario, the current study has as objective to evaluate the cost-effectiveness of the addition of rituximab to the FC protocol considering the Brazilian public health system perspective. METHODSWe developed a Markov model with three health states to extrapolate the CLL8 trial results. The transition probabilities and adverse events incidence were obtained from the trial published data. The costs were assessed from Brazil’s ministry of health pricing database (public available). A simplified treatment algorithm was developed according to the current available treatment options in the Brazilian public health system and assuming the availability of rituximab. RESULTSThe addition of rituximab to the FC regimen results in an incremental cost-effectiveness ratio (ICER) of 8389 USD (45003,86 BRL) per year life free of progression. The sensititvity analysis conducted shows a From the Brazilian public health system perspective, the combination of rituximab with the FC chemotherapy represents a cost-effective strategic approach for first-line treatment of patients with CLL.CONCLUSIONSconsidering the data described in this study, we cqn conclude that the addition of rituximab to the first-line treatment of CLL is cost-effective strategy for the Brazil public health system. With the advent of new drugs and new treatment regimens that presents positive clinical outcomes in patients refratary to the R-FC regimen (del17p, p53 mutations), new studies must be conducted to evaluate their cost-effectiveness considering this population of patients.
Differential effects of COVID-19 lockdowns on well-being: interaction between age, gender and chronotype
Authors: Oved Shay , Mofaz Merav , Lan Anat , Einat Haim , Kronfeld-Schor Noga , Yamin Dan , Shmueli Erez 
Published: January 2021

Abstract
The unprecedented restrictions imposed due to the COVID-19 pandemic, including movement control orders and lockdowns, altered our daily habits, and severely affected our well-being and physiology.
The effect of these changes is yet to be fully understood.
Here, we analyzed highly detailed data on 169 participants for 2-6 months, before and during the second COVID-19 lockdown in Israel.
Our entire study was conducted during the COVID-19 pandemic, and therefore is the first to decipher the specific effects of the lockdown from the general effects of the pandemic.
We extracted 12 well-being indicators from sensory data of smartwatches and from self-reported questionnaires, filled on a daily basis using a designated mobile application.
We used a mixed ANOVA model to study the interplay between age, gender, and chorotype on well-being before and after lockdowns.
We found that at the population level, lockdowns resulted in significant changes in mood, sleep duration, sport duration, social encounters, resting heart rate, and the number of steps.
The lockdown's adverse effects were greater for young early chronotypes who did not increase their sleep duration, reduced activity level and suffered from significantly reduced mood, and for women, who further suffered an increase in stress levels and a greater decline in social encounters.
Our findings underscore that while lockdowns severely impacted our well-being and physiology in general, greater damage has been identified in certain subpopulations.
Based on the observed effects, special attention should be given to younger people, who are usually not in the focus of social support, and to women.
The Relationship between Cigarette Smoking and IgA Nephropathy
Authors: Wang Siqing , Qin Aiya , Pei Gaiqin , Jiang Zheng , Dong Lingqiu , Tan Jiaxing , Tan Li , Tang Yi , Qin Wei 
Published: January 2021

Abstract
Background and aim: Regarding that whether cigarette smoking is associated with the progression of IgA nephropathy (IgAN) remains uncertain, we aimed to evaluate the effect of cigarette smoking on the prognosis of IgAN.Methods: 1239 IgAN patients who meet inclusion criteria from West China Hospital of Sichuan University were divided into smoker and non-smoker group. The endpoint was end stage renal disease (ESRD: eGFR <15 mL/min/1.73 m2 or having renal replacement treatment) and/or eGFR decreased>50%. Kaplan-Meier and Cox proportional hazards analyses were performed. Association of cigarette smoking and IgAN was further verified by propensity-score-matched cohort analysis.Results: During the mean follow-up period of 61 months, 40 out of 209 (19%) patients in smoker group and 110 out of 1030 (11%) in non-smoker group reached study endpoint(p<0.001). Multivariate Cox regression analysis revealed that cigarette smoking (HR=1.58,p=0.043), female gender (HR=2.00,p=0.002), Hypertension (HR=1.50,p=0.029), Serum creatinine (HR=1.01,p<0.001), segmental glomerulosclerosis (HR=1.59,p=0.026), and tubular atrophy/interstitial fibrosis (HR=3.13,p<0.001) were independent risk factors for prediction of poor renal outcome of IgAN. After matching with propensity scores, the significant correlation between cigarette smoking and the renal outcomes of IgAN patients can be seen.Conclusion: Smoking is an independent risk factor for the progression of IgAN, especially for female subjects.
Detection of Infiltrating Fibroblasts by Single-Cell Transcriptomics in Human Kidney Allografts
Authors: Suryawanshi Hemant , Yang Hua , Lubetzky Michelle , Morozov Pavel , Lagman Mila , Alonso Alicia , Li Carol , Snopkowski Catherine , Mueller Franco , Lee John , Dadhania Darshana , Salvatore Steven , Seshan Surya , Sharma Vijay , Suthanthiran Manikkam , Tuschl Thomas , Muthukumar Thangamani 
Published: January 2021

Abstract
We tested the hypothesis that single-cell RNA-sequencing (scRNA-seq) analysis of human kidney allograft biopsies will reveal distinct cell types and states and yield insights to decipher the complex heterogeneity of alloimmune rejection. We selected 3 kidney biopsies from 3 individuals for scRNA-seq and processed them fresh using an identical protocol on the 10x Chromium platform; (i) HK: native kidney biopsy from a living donor, (ii) AK1: allograft kidney with transplant glomerulopathy and tubulointerstitial fibrosis, and worsening graft function, and (iii) AK2: allograft kidney after successful treatment of active antibody-mediated rejection. We generated 7217 high-quality single cell transcriptomes. Taking advantage of the recipient-donor sex mismatches, we determined that in AK1 with fibrosis, more than half of the kidney allograft fibroblasts were—unexpectedly—recipient-derived and therefore likely migratory and graft infiltrative, whereas in the AK2 without fibrosis, all the fibroblasts were donor-derived. Furthermore, AK1 was enriched by tubular cells that overexpressed profibrotic extracellular matrix genes. AK2, eight months after successful treatment of rejection, contained endothelial cells that expressed T-cell chemoattractant cytokines. In addition to these key findings, our analysis revealed unique cell types and cell states. Altogether, single cell transcriptomics yielded novel mechanistic insights for individualizing the care of transplant recipients.
A Meta-Analysis of PCOS-Related Reproductive Abnormalities in Women Taking Valproate for Epilepsy
Authors: Li Shumin , Zhao Shigang , Gao Xueying , Yu Zhiheng , Ma Jinlong , Geng Ling 
Published: January 2021

Abstract
Although a series of studies have been undertaken to clarify the effects of valproate (VPA) on reproductive endocrinology in female, no consistent conclusion has been reached. We aimed at quantifying the association between valproate (VPA) and reproductive endocrine abnormalities in women with epilepsy. We searched scientific literatures in English language published on electronic databases of PubMed, SinoMed and EMBASE before April 2020. These studies included were prospective and controlled. We then performed meta-analysis for polycystic ovary syndrome (PCOS) and its main characteristics in women with epilepsy treated with VPA. Results showed that there were statistically differences between the VPA treated and other AEDs group with epilepsy in PCOS (p<0.001, OR 4.08, 95% CI 2.77-6.01), PCO (p<0.001, OR 2.58, 95% CI 1.90-3.51), hyperandrogenism (p<0.001, OR 2.31, 95% CI 1.66-3.23) and menstrual disorder (p<0.001, OR 1.71, 95% CI 1.32-2.22). In conclusion, VPA chronic medication lead to higher risk of developing PCOS, PCO, hyperandrogenism and menstrual disorder in women with epilepsy.