bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tolerance during 29 days of conventional dosing with cimetidine, nizatidine, famotidine or ranitidine
Authors: Nwokolo C. U. , Smith J. T. L. , Gavey C. , Sawyerr A. , Pounder R. E. 
Published: December 2024

SUMMARYTwenty‐four‐hour intragastric acidity and 24‐h plasma gastrin concentration were measured on four occasions in six groups of eight healthy male subjects. Each group was studied before dosing, and on days 1, 15 and 29 of dosing with a standard regimen of an H2‐receptor antagonist (cimetidine 800 mg node, nizatidine 300 mg node, famotidine 40 mg node, ranitidine 150 mg node, ranitidine 150 mg b.d., or ranitidine 300 mg node). On the first day of dosing, each regimen using an H2‐antagonist caused a significant decrease of intragastric acidity and a significant rise of plasma gastrin concentration. Continued dosing with each Hi‐antagonist resulted in a significant attenuation of the effect on intragastric acidity, which was most noticeable overnight, but no significant change of plasma gastrin concentration. When grouped together, median integrated nocturnal acidity for the 48 subjects was 485, 35, 67 and 117 mmol. h/L for days 0, 1, 15 and 29, respectively, associated with a median nocturnal integrated plasma gastrin concentration of 46, 72, 79 and 73 pmol. h/L.The study demonstrates that a degree of tolerance develops during continued dosing with all available H2‐receptor antagonists, and that this phenomenon occurs during sustained elevation of plasma gastrin concentration.
The effects of 15 days of dosing with placebo, sufotidine 600 mg nocte or sufotidine 600 mg twice daily upon 24‐hour intragastric acidity and 24‐hour plasma gastrin
Authors: Rogers M. J. , Holmfield J. H. M. , Primrose J. N. , Johnston D. 
Published: December 2024

SUMMARYThe acid inhibitory effect of sufotidine, a potent, long‐lasting, competitive H2‐receptor antagonist, was studied in 12 healthy males in a double‐blind, randomized, three‐way cross‐over study of the effect of placebo, sufotidine 600 mg node and sufotidine 600 mg b.d. given over 15 days.On day 1 and 15 of dosing with each regimen, each subject's 24‐h ambulatory intragastric acidity was measured by radiotelemetry and 24‐h plasma gastrin profiles were derived from hourly venous blood samples.Acid suppression was calculated as the decrease in the area under the curve of hydrogen ion activity vs time from that observed on placebo, and 24‐h plasma gastrin calculated as the area under the curve of plasma gastrin concentration vs time.Twenty‐four hour intragastric acidity during the fifteenth day of dosing with sufotidine 600 mg node and sufotidine 600 mg b.d. did not differ significantly, but on the first and fifteenth day of dosing nocturnal acidity was decreased to a greater extent by sufotidine 600 mg nocte than sufotidine 600 mg b.d. (P < 0.005). After 15 days, the acid suppression afforded by sufotidine 600 mg b.d. was significantly attenuated (P < 0.0005); this was associated with a rise in 24‐h plasma gastrin (P < 0.001).Thus, tolerance to the acid inhibitory effect of H2‐receptor antagonists exists and is of rapid onset. We suggest that tolerance is mediated by the temporally associated rise in 24‐h plasma gastrin, but we cannot exclude the possibility that other mechanisms, such as up‐regulation of H2‐receptors, also play a part.
3D‐printed porous mullite lattice structures by hybrid direct ink writing of silicone suspension‐emulsions
Authors: Diamanti Valeria , Elsayed Hamada , Bernardo Enrico 
Published: December 2024

AbstractSilicones added with nano‐sized alumina particles are already known as starting materials for phase pure mullite ceramics, synthesized at quite low temperatures. The present paper deals with a fundamental upgrade, based on a novel suspension‐emulsion concept, for the easy fabrication of highly porous lattice structures. An aqueous suspension of γ‐Al2O3 nanoparticles in water was first distributed as emulsion within an “oily phase,” consisting of a silicone/acrylates blend, with the help of a surfactant. The mixture was later employed to fabricate highly porous structures (∼80% open porosity), by direct ink writing, that is, an extrusion‐based 3D printing technology requiring specific rheological behavior of the feedstock ink. Finally, the structures were rapidly stabilized through a photo‐polymerization step (configuring a form of “hybrid” direct ink writing). The presence of water also allowed the application of a freeze‐curing procedure, for a second series of samples. The abundant water vapor release from the starting mixtures, upon firing (up to 1300°C), led to structures with enhanced pore interconnectivity. The freeze‐curing protocol proved beneficial to the homogeneity of pore distribution and to the achievement of high strength‐to‐density ratios.
A Zero Serial Cross‐Correlation Test Before Fitting Heteroscedasticity
Authors: Ma Yaolan , Chen Xiaohong , Peng Liang , Zhang Rongmao 
Published: December 2024

ABSTRACTMany statistical inferences for a multivariate innovation‐based copula time series model rely on the serial independence of innovation vectors after filtering the conditional means and conditional covariance. Zero (respectively nonzero) serial cross‐correlations for the heteroscedastic noises before filtering the conditional covariance may suggest the use of univariate (respectively multivariate) GARCH models. This paper develops a zero serial cross‐correlation test for the heteroscedastic noises with heavy tails before fitting a multivariate heteroscedasticity model. Applications to exchange rates and mutual fund returns show that this critical assumption could be problematic sometimes and conducting such a test is necessary before building and using a multivariate innovation‐based copula time series model.
Varieties of anti‐imperialism in modern China, 1890s–1920s
Authors: Jiaying Zhou 
Published: December 2024

AbstractThe modern critique of imperialism as a political economical system first emerged in Britian in late 19th century and quickly developed along two major paths: a capitalist critique and Marxian socialist one. Both critiques reached China during this period, but the Marxian socialist interpretation proved especially attractive to Chinese activists and intellectuals in part because of the influence of the Third Communist International (Comintern) but also because of the socialists' ready embrace of the linkage between anti‐imperialism and national and social revolution. This article examines the varieties of anti‐imperialist thought in late Qing and early Republican China to explain the distinctiveness of the Chinese response to the global problem of foreign imperialism in the early twentieth century, stressing the critical role played by the Chinese understandings of the nation in the process and explaining why and how the socialist anti‐imperialist critique proved more persuasive in the Chinese context.
Deodorant Spray‐Induced Cold Burns: A Case of Child Abuse
Authors: Guez Sophie , Tambuzzi Stefano , Barbara Giussy , Micci Laila Giorgia , Marchisio Paola , Somigliana Edgardo , Candia Domenico D. I. , Cattaneo Cristina , Cavalli Riccardo 
Published: December 2024

ABSTRACTMunchausen syndrome by proxy is extremely difficult to diagnose. A case is presented of a 17‐month‐old girl who repeatedly sustained cold burns caused by a spray deodorant and inflicted by her mother. A comprehensive medical investigation, including blood assessments, skin biopsies and imaging were inconclusive. The pivotal finding for the diagnosis was the detection of aluminum at high concentrations in the skin swab specimens utilizing mass spectrometry.
Successful Kidney Transplantation for Bilateral Renal Hypoplasia With Ebstein Disease
Authors: Kimura Sho , Nagatomo Yusaku , Nishiyama Kei , Nagata Hazumu , Ohga Shouichi 
Published: December 2024

ABSTRACTBackgroundPatients with renal hypoplasia are often associated with congenital heart disease (CHD). During the perioperative period of kidney transplantation (KTx), sufficient circulation volume is required to maintain renal blood flow in the donor kidney. However, little is known about the indication and management of KTx in patients with CHD who require precise hemodynamic assessment during transplantation. We report a pediatric case of successful living‐donor KTx for renal hypoplasia with unrepaired Ebstein disease.MethodsTo ensure adequate blood flow to the donor kidney during the perioperative period, the hemodynamic response to rapid administration of saline solution was evaluated in catheterization using the concept of circulatory equilibrium.ResultsThe patient received 500 mL/m2 of saline solution in 30 min, resulting in increases in RA pressure from 6 to 10 mmHg and PACW pressure from 10 to 13 mmHg, whereas CI decreased from 5.99 to 5.33 L/min/m2. These findings suggested that the patient was already in a volume overload state and required to shift the output curve upward rather than additional overloading to increase CI. Inotropic agents were used aggressively during the perioperative period of KTx to ensure adequate blood flow to the donor kidney.ConclusionsMaintaining adequate blood flow to the donor kidney is crucial during the perioperative period of KTx in patients with cardiac issues. Evaluating the response to saline solution administration using the concept of circulatory equilibrium is useful for understanding hemodynamic status and determining how to appropriately increase cardiac output.
Biological amelioration of water stress in rapeseed (Brassica napus L.) by exopolysaccharides‐producing Pseudomonas protegens ML15
Authors: Ajijah Nur , Fiodor Angelika , Dziewit Lukasz , Pranaw Kumar 
Published: December 2024

AbstractRapeseed (Brassica napus L.) is a globally significant oilseed crop with high economic value. However, water deficit significantly limits its growth and productivity. Exopolysaccharides (EPS)‐producing bacteria offer a promising strategy to counteract drought stress, leveraging their high water retention capabilities and plant growth‐promoting (PGP) properties. This study was conducted to characterize the PGP traits of selected EPS‐producing bacteria strains and evaluate its efficacy in enhancing rapeseed resilience under drought conditions. Among five EPS‐producing bacteria evaluated, Pseudomonas protegens ML15 was selected for its best performance. This strain demonstrated a range of plant growth‐promoting traits, such as the solubilization of phosphate, potassium, and zinc, alongside the production of ammonia, siderophores, and proline. It also exhibited antioxidant activity and the ability to form biofilms, even under water‐stressed conditions. Inoculation of rapeseed with strain ML15 increased germination percentages and seedling length. Notably, whether rapeseed plants were subjected to drought‐induced stress or maintained under normal conditions, treatment with P. protegens ML15 inoculation consistently improved plant length and overall biomass. Under drought‐stressed conditions, inoculated plants exhibited reduced malondialdehyde levels and increased vegetation indices, chlorophyll, protein, proline, and phenolic content. They also showed enhanced activity of antioxidant enzymes, such as catalase and peroxidase, compared to uninoculated rapeseed plants. These findings underscore the potential of EPS‐producing bacteria like P. protegens ML15 to mitigate water stress in plants, providing ecological and economic benefits that support agricultural sustainability.
Melatonin enhances metal oxide nanoparticles tolerance in rice seedlings through dual regulation of antioxidant defense and photosynthetic efficiency
Authors: Gharib Ahmed , Su Yanze , Zuo Zhihao , Chen Rujia , Wang Hanyao , Tao Tianyun , Chuan Mingli , Bu Qing , Luo Yanmo , Li Yaoqing , Wang Shuting , Hua Yu , Ji Yi , Ding Jianheng , Liu Wei , He Shuihua , Li Pengcheng , Xu Yang , Xu Chenwu , Lu Yue , Yang Zefeng 
Published: December 2024

AbstractThe growing utilization of metal oxide nanoparticles (MONPs) presents novel and potential hazards to plants. However, the impacts of MONPs on plants and the mechanisms underlying their tolerance to MONPs remain unclear. In this study, we demonstrated that both CuO and ZnO nanoparticles hindered plant growth and triggered oxidative damage in rice seedlings. The role of melatonin in rice tolerance to MONPs was elucidated through a comprehensive analysis of OsCOMT mutant and overexpression plants, which showed melatonin deficiency and sufficiency, respectively. Our results revealed that the melatonin‐deficient OsCOMT mutant plants exhibited hypersensitivity to MONPs, while the melatonin‐sufficient OsCOMT overexpression plants showed enhanced MONPs tolerance. Physiological assessments further indicated that melatonin counteracted rice oxidative damage triggered by MONPs by increasing the activities of antioxidative enzymes, including superoxide dismutase, peroxidase, catalase, and glutathione reductase. Moreover, melatonin was found to foster rice growth under MONP stress by positively regulating the maximum photochemical efficiency, reducing non‐photochemical fluorescence quenching, and promoting the biosynthesis of sucrose and starch. These findings not only highlight the hazardous effects of MONPs on plants, but also underscore the pivotal role of melatonin in bolstering plant resilience against MONPs.
Evolving patterns of first blood product use in trauma in the era of hemorrhage control resuscitation
Authors: Asif Maryam , Haider Safee U. , Liu Zhinan , Stansbury Lynn G. , Hess John R. 
Published: December 2024

AbstractBackgroundWe reviewed trauma blood use at our US regional trauma center 2011–2022—including PROPPR trial participation 2012–2014 and initiation of whole blood availability in 2019—to assess the implementation of early coagulation support in acute trauma care.Study Design/MethodsWe identified all acute trauma patients recorded by our Trauma Registry as arriving at our large US regional Level 1 trauma center from April 6, 2011 (Blood Bank opening) through December 2022. Patient cohort data were then linked directly to Blood Bank final‐product‐issue date/time data to identify patients receiving any blood product in the first 24 h of care and then, specifically, at least one unit of Red Blood Cells (RBC), Plasma, or Whole Blood (WB). Results were binned as: “RBC first,” “Plasma first,” “Both at the same time,” or “WB first.”ResultsOver the study period, 73,634 acute trauma patients received care, and 12,927 received at least one unit of a blood product. The proportion receiving plasma or a combination of plasma and RBCs as the initial transfusion increased after 2015 from 33% to 66%, while the proportion receiving packed RBCs alone decreased from 57% to about 18%. Since its introduction in 2019, the use of WB as the first product has grown to 20%.ConclusionsThis retrospective cohort study documents the increasing use of plasma and now WB as initial products issued in trauma resuscitation, reflecting acceptance of coagulation support as the standard of care and the use of hemostatic resuscitation protocols.
Biotinylation of human platelets is compatible with pathogen inactivation treatment and cold storage for clinical studies
Authors: Muret Charlotte , Crettaz David , Martin Agathe , Aliotta Alessandro , Bertaggia Calderara Debora , Alberio Lorenzo , Prudent Michel 
Published: December 2024

AbstractBackgroundProduction of platelet concentrates (PCs) involves several steps that significantly affect platelet behavior. To gain a deeper understanding of how storage conditions impact donor platelet recirculation and functionality post‐transfusion, ex vivo platelet labeling is a feasible approach. However, before pursuing clinical investigations of platelet recirculation and function in humans, we aimed to determine the effects of pathogen inactivation technology (PIT) and storage conditions (4°C vs. room temperature [RT]) on phenotype and function of biotinylated platelets compared to conventional PIT PCs for transfusion.MethodsNine PCs were prepared in 61% additive solution from 45 buffy coats (five buffy coats each). A pool‐and‐split of three units was used to prepare three equivalent PCs: two labeled with biotin and stored at RT or 4°C, and one without labeling and stored at RT. All PCs were then treated by PIT (amotosalen/UVA) and stored for 14 days. Labeling efficiency, platelet concentration, metabolic parameters, aggregation response (ADP, collagen, co‐aggregation with epinephrine), and platelet phenotype (CD42b, CD62‐P, phosphatidylserine) at the basal stage and upon stimulation (ADP or TRAP‐6) were performed.ResultsLabeling efficiency of PIT and 4°C PCs was stable over 14 days of storage. Differences in platelet function and phenotype were mainly due to the storage temperature and not the biotinylation process. Phenotypes at baseline or after stimulation were equivalent in biotin‐positive and biotin‐negative platelets.ConclusionBiotin‐labeled platelets can effectively enable investigation of the effects of PIT and storage temperature for clinical studies. This method shows great potential for improving platelet transfusion knowledge.
Computed tomographic findings in 25 cats with ear canal neoplasia
Authors: Wisnoski Megan , Gremillion Christine , Levine Gwendolyn , Coy Cambridge , Veitch Kaylynn , Waller Kenneth , Griffin John F. 
Published: December 2024

AbstractComputed tomography is commonly used to evaluate feline otic disease; however, published studies characterizing the CT appearance of ear canal neoplasia are limited. The purpose of this multicenter, retrospective, secondary analysis, cross‐sectional study was to describe the CT features of histopathologically confirmed feline ear canal neoplasia. The CT studies of 25 cats with ear canal neoplasia were prospectively scored by consensus of two veterinary radiologists. Recorded parameters were the presence of focal or multifocal tissue enlargement (mass/masses), lesion shape, location of the center of mass, attenuation characteristics, features of contrast enhancement, involvement of otic structures, calvarial and brain changes, changes of nearby structures, and lymphadenopathy. There was a significant overlap of CT findings between cats with malignant ceruminous gland neoplasia, ceruminous gland adenoma, and squamous cell carcinoma (SCC). Ceruminous gland adenoma was typically homogeneous in attenuation with homogeneous contrast enhancement and no intralesional fluid accumulations (IFAs) or involvement of adjacent structures. In contrast, SCC consistently had heterogeneous attenuation, heterogeneous contrast enhancement, IFAs, and involvement/invasion of adjacent structures. Malignant ceruminous gland neoplasia had variable attenuation and pattern of contrast enhancement with occasional IFAs and occasional involvement/invasion of adjacent structures. Knowledge of these imaging features will inform the creation of prioritized differential diagnosis lists. However, a biopsy is required to confirm the diagnosis.
Lumbosacral transitional vertebrae in small‐breed dogs: Prevalence, classification, and characteristics
Authors: Kim Uhjin , Chang Jinhwa , Yoon Kwangyong , Kim Byungjin , Ban Jiyoung , Hyun Sang‐Hwan , Chang Dongwoo , Lee Namsoon 
Published: December 2024

AbstractThe lumbosacral transitional vertebra (LTV) is an abnormally formed vertebra that can be associated with cauda equina syndrome, lumbosacral (LS) degeneration, and pelvic rotation. However, there is little information on LTV in small‐breed dogs, and no studies have investigated the association between LTV and LS diseases or degenerative changes in the coxofemoral joints. The purpose of this multicenter, retrospective, and cross‐sectional study was to determine the prevalence of LTV in small‐breed dogs (<10 kg), classify the type of LTV, and identify its association with degenerative changes in the LS and coxofemoral joints using CT images. Lumbosacral transitional vertebrae were divided into four types based on their morphological characteristics. Lumbosacral transitional vertebrae were detected in 127 of 812 dogs (15.6 %). The prevalence of LTV was higher in French bulldogs (33.3%), Schnauzers (33.3%), and Dachshunds (25%) than in other breeds. Type 2 was the most common, with morphological variations in the transverse processes, and 36.2% of the LTV group showed multiple types of LTV. Dogs with LTV tended to have LS spondylosis deformans (OR, 2.8) and pelvic rotation (OR, 6.4) compared with dogs without LTV. Type 4 LTV was significantly associated with pelvic rotation (p < 0.0001). This is the first study to investigate the prevalence, characteristics, and characteristics of LTV in small‐breed dogs using CT images. The results of this study may contribute to a better understanding of this congenital anomaly in small‐breed dogs. CT can evaluate LTV, which could predispose a dog to LS spondylosis deformans or pelvic rotation.
On Fuchs' problem for finitely generated abelian groups: The small torsion case
Authors: Del Corso I. , Stefanello L. 
Published: December 2024

AbstractA classical problem, raised by Fuchs in 1960, asks to classify the abelian groups which are groups of units of some rings. In this paper, we consider the case of finitely generated abelian groups, solving Fuchs' problem for such groups with the additional assumption that the torsion subgroups are small, for a suitable notion of small related to the Prüfer rank. As a concrete instance, we classify for each the realisable groups of the form . Our tools require an investigation of the adjoint group of suitable radical rings of odd prime power order appearing in the picture, giving conditions under which the additive and adjoint groups are isomorphic. In the last section, we also deal with some groups of order a power of 2, proving that the groups of the form are realisable if and only if or is a Fermat prime.
Single-dose tolerability and pharmacokinetics of leritrelvir in Chinese patients with hepatic impairment and healthy matched controls
Authors: Li Cuiyun , Mai Jiajia , Wu Min , Zhang Hong , Li Xiaojiao , Li Haijun , Li Youyun , Ding Yanhua 
Published: December 2024

ABSTRACT

This study evaluated the safety and pharmacokinetics (PK) of a single dose of leritrelvir, a novel inhibitor of 3-chymotrypsin-like cysteine protease (3CLpro), in patients with hepatic impairment versus healthy participants with normal hepatic function. Eight participants with mild (Child–Pugh A) hepatic impairment, eight with moderate (Child–Pugh B) hepatic impairment, and eight healthy matched control participants were enrolled in this open-label, parallel clinical trial. After administration of leritrelvir of 400 mg, PK parameters were calculated and compared across groups. In total, 24 participants were enrolled and completed the study. Leritrelvir was generally well tolerated, with no serious adverse events or deaths reported during the study. Compared to the group with normal hepatic function, the geometric least-squares mean ratios (90% confidence intervals) for
C
max
, AUC

0-
t

, and AUC
0-∞
of leritrelvir in participants with mild hepatic impairment were 96.9% (69.3%, 135%), 92.2% (69.6%, 122%), and 92.1% (69.7%, 122%), respectively. For moderate hepatic impairment, the corresponding ratios were 91.6% (61.7%, 136%), 113% (80.0%, 160%), and 113% (80.0%, 159%). Leritrelvir exposures were comparable among the three groups. Overall, there was no clinically relevant difference in leritrelvir exposure in participants with hepatic impairment compared to normal controls. No dose adjustment is required for leritrelvir in patients with mild or moderate hepatic impairment.

CLINICAL TRIALS

This study is registered with ClinicalTrials.gov as
NCT06161259
.