bluuebunny/crossref_metadata_2025_split huggingface dataset:
Donor impurity related optical and electronic properties of cylindrical GaAs-AlxGa1−x As quantum dots under tilted electric and magnetic fields
Authors: Heyn Christian , Duque C. A. 
Published: June 2020

AbstractThis article makes a theoretical study of the optical and electronic properties in cylindrical GaAs-Alx Ga1−x As quantum dots in the presence of an arbitrarily located donor impurity and considering the simultaneous effects of tilted electric and magnetic fields. The studies are developed in the effective mass and parabolic band approximations. The solution of the Schrödinger equation is done through the finite element method considering tetrahedral meshes that can be adapted to regions where there are abrupt variations of the materials that make up the structure. Among the many results, reported for the first time in this article, we can mention: (i) the electronic spectrum, without and with shallow donor impurity, considering separate and combined effects of tilted electric and magnetic fields, (ii) the ground state binding energy as a function of the external electric and magnetic fields, their orientations concerning the axial axis of the quantum dot, and the impurity position, (iii) the squared reduced dipole matrix elements for impurity related inter-level optical transitions as a function of the tilted electric and magnetic fields and impurity position, and (iv) the optical absorption coefficient between the ground state and at least the first fifteen lowest excited states under tilted electric and magnetic fields and considering several impurity positions. From this study it can be concluded that the presence of tilted electric and magnetic fields and on-center or off-center shallow donor impurities, ostensibly enrich the optical and electronic properties of the system. It is observed that due to the rupture of the azimuthal symmetry of the cylindrical quantum dot, important modifications of the selection rules for inter-level transitions between states appear.
Dedicated core-on-anvil production of bladelet-like flakes in the Acheulean at Thomas Quarry I - L1 (Casablanca, Morocco)
Authors: Gallotti Rosalia , Mohib Abderrahim , Fernandes Paul , El Graoui Mohssine , Lefèvre David , Raynal Jean-Paul 
Published: June 2020

AbstractThe ability to produce large cutting tools (LCTs) is considered as the technological marker of the Acheulean and the indicator of a greater technological complexity compared to the previous Oldowan. Although Acheulean techno-complexes are also composed of a concurrent core-and-flake technology, the iconic handaxes have attracted more attention than any other lithic component. Consequently, little is known of the small and medium-sized flake productions (small flaking), especially starting from 1 Ma, when handaxe and cleaver manufacture becomes intensive and widespread across Africa, including the Atlantic coastal regions of Morocco. Research at Thomas Quarry I yielded a rich early Acheulean lithic assemblage, mainly composed of quartzite LCTs and small flaking, together with a small-sized flint production. Here, we report a particular aspect of this flint assemblage, i.e. a flint bladelet-like flake production. This process represents a discrete technical behaviour among those related to small flaking both in quartzite and flint: pebbles were flaked using the bipolar-on-anvil technique repeatedly employing a specific method to produce bladelet-like flakes. This production represents the oldest dated occurrence of bladelet-like technology in Africa and reveals technical competencies hitherto unknown for these periods, providing further elements for the techno-economic diversification of the African Acheulean.
The impact of capsaicinoids on APP processing in Alzheimer’s disease in SH-SY5Y cells
Authors: Grimm Marcus O. W. , Blümel Tamara , Lauer Anna A. , Janitschke Daniel , Stahlmann Christoph , Mett Janine , Haupenthal Viola J. , Miederer Anna-Maria , Niemeyer Barbara A. , Grimm Heike S. , Hartmann Tobias 
Published: June 2020

AbstractThe vanilloid capsaicin is a widely consumed spice, known for its burning and “hot” sensation through activation of TRPV1 ion-channels, but also known to decrease oxidative stress, inflammation and influence tau-pathology. Beside these positive effects, little is known about its effects on amyloid-precursor-protein (APP) processing leading to amyloid-β (Aβ), the major component of senile plaques. Treatment of neuroblastoma cells with capsaicinoids (24 hours, 10 µM) resulted in enhanced Aβ-production and reduced Aβ-degradation, leading to increased Aβ-levels. In detailed analysis of the amyloidogenic-pathway, both BACE1 gene-expression as well as protein-levels were found to be elevated, leading to increased β-secretase-activity. Additionally, γ-secretase gene-expression as well as activity was enhanced, accompanied by a shift of presenilin from non-raft to raft membrane-domains where amyloidogenic processing takes place. Furthermore, impaired Aβ-degradation in presence of capsaicinoids is dependent on the insulin-degrading-enzyme, one of the major Aβ-degrading-enzymes. Regarding Aβ-homeostasis, no differences were found between the major capsaicinoids, capsaicin and dihydrocapsaicin, and a mixture of naturally derived capsaicinoids; effects on Ca2+-homeostasis were ruled out. Our results show that in respect to Alzheimer’s disease, besides the known positive effects of capsaicinoids, pro-amyloidogenic properties also exist, enhancing Aβ-levels, likely restricting the potential use of capsaicinoids as therapeutic substances in Alzheimer’s disease.
The Influence of Oil leaking rate and Ocean Current Velocity on the Migration and Diffusion of Underwater Oil Spill
Authors: Ji Hong , Xu Manlin , Huang Weiqiu , Yang Ke 
Published: June 2020

AbstractSevere environmental pollution and huge economic losses would be caused by submarine oil spill with the increasing development of petroleum energy in sea. In order to predict the law of migration of oil spill from submarine pipelines accurately, the volume of fluid (VOF) model and realizable k-ε turbulence model were employed to establish numerical simulation of submarine oil spill, and the experiments were used to verify the feasibility of the numerical models. Different oil leaking rate and ocean velocity were simulated in the study. The simulation results indicated that comparing with oil leaking rate (set vertical migration velocity, Uo), current velocity (set horizontal migration velocity, Uw) has a greater influence on the migration of the oil spilling; the actual vertical migration velocity (Uo1), actual horizontal migration velocity (Uw1) and R1 (the ratio of Uo1 and Uw1) are positively correlated with R (the ratio of Uo and Uw), and they both fluctuate within a small range no matter how large R is; when 20 ≤ R ≤ 150, R1 fits a linear fit curve with curve as R1 = 0.66932 + 0.00215 R, which can provide a theoretical reference to the recovery system of underwater pipeline oil spilling emergency.
3D MHD nonlinear radiative flow of CuO-MgO/methanol hybrid nanofluid beyond an irregular dimension surface with slip effect
Authors: Tlili Iskander , Nabwey Hossam A. , Samrat S. P. , Sandeep N. 
Published: June 2020

AbstractThe 3D MHD nonlinear radiative hybrid nanofluid flow across an irregular dimension sheet with slip effect is studied numerically. The hybrid nanofluid consists of copper oxide (CuO) and magnesium oxide (MgO) nanoparticles embedded in methanol or methyl alcohol (MA). The governing PDEs’ are altered as ODEs’ using similarities and numerical solutions are attained using shooting scheme. The role of corporal factors on the transport phenomenon is analyzed and reflected by plots and numerical interpretations. Simultaneous solutions presented for CuO-MA nanofluid and CuO-MgO/MA hybrid nanofluid. Results ascertain that the temperature and flow boundary layer thicknesses are not unique for the hybrid nanofluid and nanofluid. The heat transfer enactment of CuO-MA nanofluid is high when equated to CuO-MgO/MA hybrid nanofluid. This concludes that the CuO-MgO combination works as a good insulator.
Investigation on the Electrochemical Performances of Mn2O3 as a Potential Anode for Na-Ion Batteries
Authors: Yusoff Nor Fazila Mahamad , Idris Nurul Hayati , Din Muhamad Faiz Md. , Majid Siti Rohana , Harun Noor Aniza , Rahman Md. Mokhlesur 
Published: June 2020

AbstractCurrently, the development of the sodium-ion (Na-ion) batteries as an alternative to lithium-ion batteries has been accelerated to meet the energy demands of large-scale power applications. The difficulty of obtaining suitable electrode materials capable of storing large amount of Na-ion arises from the large radius of Na-ion that restricts its reversible capacity. Herein, Mn2O3powders are synthesised through the thermal conversion of MnCO3and reported for the first time as an anode for Na-ion batteries. The phase, morphology and charge/discharge characteristics of Mn2O3obtained are evaluated systematically. The cubic-like Mn2O3with particle sizes approximately 1.0–1.5 µm coupled with the formation of Mn2O3sub-units on its surface create a positive effect on the insertion/deinsertion of Na-ion. Mn2O3delivers a first discharge capacity of 544 mAh g−1and retains its capacity by 85% after 200 cycles at 100 mA g−1, demonstrating the excellent cyclability of the Mn2O3electrode. Therefore, this study provides a significant contribution towards exploring the potential of Mn2O3as a promising anode in the development of Na-ion batteries.
Clinical utility of early postoperative cardiac multidetector computed tomography after coronary artery bypass grafting
Authors: Kang Doo Kyoung , Lim Sang Hyun , Park Jin Sun , Sun Joo Sung , Ha Taeyang , Kim Tae Hee 
Published: June 2020

AbstractWe evaluated the clinical utility of early postoperative cardiac computed tomography (CT) for evaluating left ventricular (LV) function and predicting prognosis in patients who had undergone coronary artery bypass grafting (CABG). Of the 205 patients who underwent CABG from March 2011 to December 2014, 136 underwent early postoperative cardiac CT (within 30 days after CABG) and were enrolled as the study population. The baseline and postoperative follow-up echocardiographic findings, major adverse cardiac events (MACE), and death were recorded for a follow-up period (mean, 5.9 ± 1.1 years). Functional cardiac CT parameters were compared to echocardiographic measurements. The associations between cardiac CT findings and functional recovery and prognosis were evaluated by logistic regression analyses. The LVEF measured via cardiac CT was significantly higher (56.2 ± 11.5% vs. 61.9 ± 12.9%; p = 0.0002) compared to those via early postoperative echocardiography, but the wall motion score index (WMSI) was not significantly different (1.23 ± 0.33 vs. 1.21 ± 0.28, p = 0.5041) between the two methods. During the follow-up period, 17 patients (12.5%) died and 40 (29.4%) developed MACE. Both the LVEF and WMSI measured with early postoperative echocardiography (p = 0.0202 and odds ratio [OR] = 5.0171, p = 0.0039, respectively), and cardiac CT (OR = 0.9625, p = 0.0091 and OR = 14.3605, p = 0.0001, respectively) predicted MACE OR = 0.9630, but only the WMSI, measured using cardiac CT, predicted all-cause death (OR = 10.6017, p = 0.0035). In CABG patients, LVEF and the WMSI measured with early postoperative cardiac CT were comparable with echocardiography and predicted the development of MACE and all-cause death.
Additive prognostic value of red cell distribution width over late gadolinium enhancement on CMR in patients with non-ischemic dilated cardiomyopathy
Authors: Yi Jeong-Eun , Lee Hye-Jeong , Kim Young Jin , Kim Yookyung , Joung Boyoung , Park Junbeom 
Published: June 2020

AbstractElevated red cell distribution width (RDW) and late gadolinium enhancement on cardiac magnetic resonance (LGE-CMR) are both poor prognostic factors. This study examined the relationship between RDW and LGE-CMR characteristics in patients with non-ischemic dilated cardiomyopathy (NICM), and investigated whether the additive prognostic value of RDW as an integrative systemic factor over LGE-CMR exists or not. A total of consecutive 378 patients who underwent CMR at two general hospitals in South Korea were retrospectively analyzed. The primary endpoint was a composite of all-cause death, hospitalizations due to worsening heart failure and major arrhythmic events. During a mean follow-up period of 40.8 months, 151 (39.9%) patients experienced primary endpoints. The RDW value was significantly higher in patients with LGE than in those without LGE (13.7 ± 1.5% vs. 13.3 ± 1.4%, p = 0.034), but it was not associated with the extent or distribution patterns of the LGE. Addition of RDW into the model with clinical risk factors and LGE-CMR characteristics led to a significant improvement in the prediction of worse outcomes (χ2 increased from 73 to 82; p = 0.023). RDW could provide incremental predictive value for adverse clinical events beyond LGE-CMR data in NICM patients.
Predictions of potential geographical distribution of Diaphorina citri (Kuwayama) in China under climate change scenarios
Authors: Wang Rulin , Yang Hua , Wang Mingtian , Zhang Zhe , Huang Tingting , Wen Gang , Li Qing 
Published: June 2020

AbstractClimate change significantly affects geographic distribution of plants pests and diseases worldwide. Understanding the influence of future climate change on the suitable areas of Diaphorina citri (Kuwayama) in our country and taking timely countermeasures are crucial for improving the effectiveness of control of pest. Based on the occurrence points of D. citri and the selected environmental variables, the potential suitable areas of this pest under climate change scenarios in China were predicted by using MaxEnt and GIS tools. Our results showed that the higly suitable area were mainly located in Guangxi, Guangdong, Fujian, Southern Zhejiang, Southern Jiangxi, Eastern Hunan, Southwestern Guizhou, and the area was 43.7 × 104 km2. Areas of moderate and low suitability were centered on areas of high suitability and radiate to the North successively, with an area of 59.28 × 104 km2 and 93.46 × 104 km2 respectively. From current to 2070 s, the areas of the highly suitable areas will increase, and the geometric center of the highly and total suitable areas will move to north under three climate change scenarios.
Cilostazol restores autophagy flux in bafilomycin A1-treated, cultured cortical astrocytes through lysosomal reacidification: roles of PKA, zinc and metallothionein 3
Authors: Kim Ha Na , Seo Bo-Ra , Kim Hyunjin , Koh Jae-Young 
Published: June 2020

AbstractCilostazol, a phosphodiesterase 3 inhibitor, reduces the amyloid-beta (Aβ) burden in mouse models of Alzheimer disease by as yet unidentified mechanisms. In the present study, we examined the possibility that cilostazol ameliorates lysosomal dysfunction. Astrocytes treated with bafilomycin A1 (BafA1) exhibited markedly reduced DND-189 and acridine orange (AO) fluorescence, indicating reduced lysosomal acidity. In both cases, BafA1-induced alkalization was reversed by addition of cilostazol, dibutyryl cAMP or forskolin. All three agents significantly increased free zinc levels in lysosomes, and addition of the zinc chelator TPEN abrogated lysosomal reacidification. These treatments did not raise free zinc levels or reverse BafA1-mediated lysosomal alkalization in metallothionein 3 (Mt3)-null astrocytes, indicating that the increases in zinc in astrocytes were derived mainly from Mt3. Lastly, in FITC-Aβ-treated astrocytes, cilostazol reversed lysosomal alkalization, increased cathepsin D activity, and reduced Aβ accumulation in astrocytes. Cilostazol also reduced mHtt aggregate formation in GFP-mHttQ74–expressing astrocytes. Collectively, our results present the novel finding that cAMP/PKA can overcome the v-ATPase blocking effect of BafA1 in a zinc- and Mt3-dependent manner.
MIR22HG regulates miR-486/PTEN axis in bladder cancer to promote cell proliferation
Authors: Tang Qisheng , Jiang Xue , Ma Shanjin , Wang Lei , Li Ruixiao , Ma Jianjun 
Published: June 2020

Abstract
The tumor suppressive role of MIR22HG has been studied in several types of cancer. We analyzed the TCGA dataset and found the down-regulation of MIR22HG in bladder cancer (BC). Bioinformatics analysis predicted the interaction between MIR22HG and miR-486. The direct interaction between MIR22HG and miR-486 was also confirmed by dual luciferase assay. However, overexpression of these two factors did not significantly affect the expression of each other. Interestingly, overexpression of MIR22HG led to up-regulated phosphatase and tensin homolog (PTEN), which is a target of miR-486. In cell proliferation assay, overexpression of MIR22HG and PTEN led to decreased rates of BC cell proliferation. Moreover, overexpression of miR-486 played an opposite role and attenuated the effects of overexpression of MIR22HG and PTEN. Therefore, MIR22HG regulates miR-486/PTEN axis to promote cell proliferation in BC.
To study the effect of oxygen carrying capacity on expressed changes of erythrocyte membrane protein in different storage times
Authors: Wang Huan , Wei Han-Wei , Shen Hua-Chun , Li Zhen-Zhou , Cheng Yong , Duan Li-Shuang , Yin Lei , Yu Jun , Guo Jian-Rong 
Published: June 2020

Abstract
Erythrocyte membrane is crucial to maintain the stability of erythrocyte structure. The membrane protein on the surface of erythrocyte membrane enables erythrocyte to have plasticity and pass through the microcirculation without being blocked or destroyed. Decreased deformability of erythrocyte membrane protein will lead to a series of pathological and physiological changes such as tissue and organ ischemia and hypoxia. Therefore, this research collected 30 cases of healthy blood donors, and explored erythrocyte stored at different times relating indicators including effective oxygen uptake (Q), P50, 2,3-DPG, Na+-k+-ATP. Erythrocyte morphology was observed by electron microscopy. Western blot and immunofluorescence assay were used to detect membrane protein EPB41, S1P, GLTP, SPPL2A expression changes of erythrocyte. To explore the effective carry oxygen capacity of erythrocyte at different storage time resulting in the expression change of erythrocyte surface membrane protein.
Efficient segmentation of lumbar intervertebral disc from MR images
Authors: Silvoster M Leena , Mathusoothana S. Kumar Retnaswami 
Published: June 2020

Segmentation of spine Magnetic Resonance Images (MRIs) has become an indispensable process in the diagnosis of lumbar disc degeneration, causing low back pain. Over the last decade of years, computer‐directed diagnosis of disease, as well as computer‐guided spine surgery, is based on the two‐dimensional (2D) analysis of mid‐sagittal slice of MRI. This work proposes an automatic strategy to extract the 3D segmentation of the normal disc as well as degenerated lumbar intervertebral discs (IVDs) from T2‐weighted Turbo Spin Echo MRI of the spine using Connected Component (CC) analysis algorithm and statistical shape analysis. The challenges faced by the IVD segmentation includes (i) partial volume effects (ii) intensity inhomogeneity (iii) grey level overlap of different soft tissues. The proposed method first pre‐processes the dataset and enables it for the application of the CC algorithm. The CC (subsets of pixels of the disc) of the spine MRI is extracted and apply statistical shape analysis for the refinement of the segmentation results to detect IVDs. Experimental results of the proposed method show a robust segmentation, accomplishing the dice similarity index of 92.4% and thus achieving a low error rate. Other performance measures such as Precision, Accuracy, JaccardIdx, JaccardDist, Global Consistency Error, Variation of Information, etc were also evaluated. The algorithm is evaluated quantitatively using adequate experiments on a dataset of 15 MRI scans, of different scenarios such as healthy and degenerate disc and this proposed method is verified as a promising accurate method for the automatic segmentation of IVD.
Parental Perspectives on the Postpartum Bonding Experience after Neonatal Intensive Care Unit Transfer to a Referral Hospital
Authors: Yui Yvonne , October Tessie W. 
Published: June 2020

Objective The aim of this study is to describe the postpartum bonding experience of parents whose newborns were transferred to a referral hospital while their mothers remained at the delivery hospital.Study Design A total of 18 semi-structured interviews conducted with mothers within 2 weeks of birth were completed. Thematic analysis was performed.Result In total, 72% of mothers were unable to hold their newborns, and mothers spent a median of 15 minutes with their newborn prior to transfer. Thematic analysis revealed five themes: three barriers to bonding (medical, hospital, and family barriers) and two themes of interventions that helped promote bonding (parent and hospital-initiated interventions). Using technology such as bedside cameras, recording of heart beats, and video chatting on rounds were extremely popular.Conclusion Parents identified multiple barriers to maternal–infant bonding and suggested several parent-focused and hospital-focused interventions to enhance bonding. Strategies that address barriers should be used to help parents promote bonding during separation from their newborns.Key Points
Repetitive bundles in Malaysian learner writing
Authors: Joharry Siti Aeisha 
Published: June 2020

AbstractOne way to investigate learner writing is by analyzing the most frequently recurring sequences of words, that is, lexical bundles. This paper presents results for lexical bundles analyses of a Malaysian corpus (MCSAW) against its reference language variety, LOCNESS (Louvain Corpus of Native English Essays). Key 4-word lexical bundles are firstly investigated in terms of their frequencies as well as distribution in both corpora. Following this, key lexical bundles are further categorized and analyzed according to their functions, including qualitative analysis of the most recurrent bundles by examination of concordance lines. Results show that learners use simple types of lexical bundles repeatedly compared to their native speaker counterparts. Evidence of tautology can also be found in learner writing. The findings highlight that using lexical bundles appropriately is important to achieve native-like fluency, while the absence of more varied lexical bundles in learners’ discourse may result in unidiomatic-sounding writing style.
Multilingualism in Mauritius
Authors: Auleear Owodally A Mooznah , Peeroo Swaleha 
Published: June 2020

AbstractWhile the internet facilitates communication and interaction between businesses and customers, social media platforms afford both of them opportunities to co-construct information online. These meeting points between businesses and customers, which are then displayed online, constitute a virtual linguistic servicescape showcasing their language practices. This study focuses on the Facebook pages of three fast-food outlets in multilingual Mauritius – where Kreol and French are commonly spoken, and English and French are widely written – with the aim to investigate the language choices made and displayed in the virtual linguistic servicescape. Using non-participant online observation, data were collected over three months and analysed as ‘text’ (Androutsopoulos, 2014). The data reveal the co-occurrence of local languages in the actors’ language practices, with minimal use of Kreol. These practices reinforce existing local language and literacy ideologies, while also disturbing, if only but slightly, long-entrenched ideologies about written Kreol.