bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Additional Administration of a Selective Inhibitor of Sodium Glucose co-transporter-2 Inhibitor on the Glycemic Control in Japanese Type 2 Diabetes Mellitus Patients Receiving Treatment with a Dipeptidyl Peptidase-4 Inhibitor
Authors: Kusunoki Masataka , Sato Daisuke , Sakazaki Takahiko , Miyata Tetsuro , Tsutsumi Kazuhiko , Oshida Yoshiharu 
Published: March 2020

AbstractWe conducted this study to determine whether additional administration sodium-glucose co-transporter 2 (SGLT2) inhibitor might provide further improvement of glycemic control and also to explore any advantages in Japanese type 2 diabetes patients showing relatively good glycemic control under treatment dipeptidyl peptidase-4 (DPP-4) inhibitors. We divided the patients in two groups, MT group and CT group. The MT group were continued on the DPP-4 inhibitor treatment for 6-months, and CT group were additionally administered an SGLT2 inhibitor treatment for 6-months. The MT group showed a significant decrease of hemoglobin A1c (HbA1c), but a significant increase of body weight, body mass index and serum uric acid, compared to the baseline values, while the CT group showed a significant decrease of HbA1c, body weight, BMI, and serum uric acid, and also a significant increase of serum HDL-cholesterol and decrease of serum triglyceride levels. Furthermore, this group showed a significant decrease of serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transpeptidase (γ-GTP), which are markers of liver function. These results suggest that the combination therapy is useful, in particular, for the treatment of type 2 diabetes mellitus patients with hyperlipidemia and liver dysfunction. Among the SGLT2 inhibitors added to the DPP-4 inhibitor treatment, the decreases of serum levels of AST, ALT and γ-GTP were particularly significant in the group receiving luseogliflozin, suggesting that the combination of a DPP-4 inhibitor with luseogliflozin is particularly effective for the treatment of type 2 diabetes mellitus patients with liver dysfunction.
Prävention sexualisierter Gewalt – Evaluation eines universitären Seminars für angehende Lehrkräfte
Authors: Czollek Jonathan , Muck Christoph 
Published: March 2020

Zusammenfassung
Einleitung Angesichts hoher Prävalenzen und schwerwiegender Konsequenzen von sexualisierter Gewalt sind evidenzbasierte Präventionsansätze notwendig. Eine Variante stellen hierbei universitäre Seminare für angehende Lehrkräfte dar, da diese als potentielle Multiplikator_innen verschiedene präventive Schutzfunktionen einnehmen können.
Forschungsziele Da empirische Wirksamkeitsbelege hier jedoch weitgehend fehlen, war das Ziel dieser Studie die Evaluation eines universitären Seminars zur Prävention sexualisierter Gewalt. Dazu wurden aus der Bystander- und der Selbstwirksamkeitsforschung verschiedene Wirksamkeitskriterien abgeleitet: Vorurteile, Rollenambiguität, Selbstwirksamkeitserwartung, Klarheit der Grenzeinschätzung und sorgenvolle Emotionen.
Methoden Im Rahmen eines quasi-experimentellen Designs wurden einer Interventionsgruppe, die am Seminar teilnahm (N = 22; M
Alter = 22.5, SD = 3.14), und einer Kontrollgruppe (N = 17; M
Alter = 24.29, SD = 2.37) Fragebögen vorgelegt.
Ergebnisse Die Interventionsgruppe zeigte nach der Teilnahme signifikant weniger Vorurteile (d = -.74) und höhere Selbstwirksamkeitserwartung (d = .89). Es fanden sich Hinweise darauf, dass das Seminar die Rollenambiguität senkt (η2 = .57) und die Klarheit der Grenzeinschätzung steigert (d = 1.07). In Bezug auf die sorgenvollen Emotionen wurden keine Effekte gefunden.
Schlussfolgerung Die Ergebnisse weisen auf eine Wirksamkeit des universitären Seminars hin. Praktische Implikationen zur Weiterentwicklung des Ansatzes sowie methodische Limitationen wie subjektive Messinstrumente, Stichprobengröße und Langfristigkeit der Effekte werden diskutiert.
3-(2-Isocyanoethyl)indole: A Versatile Reagent for Polycyclic Spiroindoline Synthesis
Authors: Liu Yun-Lin , Chen Guo-Shu , Lin Xiao-Tong 
Published: March 2020

Polycyclic spiroindolines are the basic skeletons of large families of indole alkaloids that exhibit a broad spectrum of biological and pharmacological activities. The past seven years have seen impressive developments in the construction of polycyclic spiroindolines enabled by 3-(2-isocyanoethyl)indole-based cascade reactions. We herein give a brief summary on this evolution and highlight our contributions in this field.1	Introduction2	Cascade Reactions Involving Nitrilium Ion Intermediates3	Cascade Reactions Involving Ketenimine Intermediates4	Conclusion and Outlook
One of the Rarest Syndromes in Dentistry: Gardner Syndrome
Authors: Basaran Guvenc , Erkan Mustafa 
Published: March 2020

ABSTRACTGardner syndrome is a rare, autosomal dominant syndrome. It will follow a positive course with diagnosis and treatment by medical and dental specialists. Orthodontists or general dental physicians can easily diagnose the syndrome through radiological images taken in addition to dental and skeletal findings. The aim of this study was therefore to report two cases of this syndrome and to evaluate it from an orthodontic perspective in order to attract the attention of orthodontists to thisrare anomaly. (Eur J Dent 2008;2:208-212)
Extrafollicular Adenomatoid Odontogenic Tumor of the Mandible: Report of a Case
Authors: Yilmaz Nergiz , Acikgoz Aydan , Celebi Nukhet , Zengin A. Zeynep , Gunhan Omer 
Published: March 2020

ABSTRACTThe purpose of this study was to report an extrafollicular adenomatoid odontogenic tumor in the mandibular anterior region in a patient. A 15 year-old female with a painless swelling in the mandibular anterior region was referred to our clinic. Fine needle aspiration yielded no fluid. Periapical, panoramic and computer tomography scans showed circumscribed radiolucent area with fine calcifications. The lesion was totally enucleated and the teeth 31, 32 were removed. The rarity of adenomatoid odontogenic tumor may be associated with its slowly growing pattern and symptomless behavior. Therefore, it should be distinguished from more common lesions of odontogenic origin in routine dental examinations. (Eur J Dent 2009;3:71-74)
Resin Gingival Barrier as a Polymerizable Try-In Paste for Dynamic Try-In of Crowns and Veneers
Authors: Abyad Ahmed , Jarrah Ziad , Hallak Amin , Ragab Hala , Osman Essam 
Published: March 2020

AbstractTry-in sessions are often performed to check the fit and shape of restorations; however, try-in pastes do not exhibit enough viscosity to keep the restoration in place especially in the case of veneers that keep falling off during try-in. The use of polymerizable soft resins similar to those used as a gingival barrier in bleaching treatment can lock the veneer or crown in place during try-in for dynamic assessment of the restoration, at the same time easy removal of the paste is possible since the resin film is peeled off in one piece leaving no residues for cleanup.
Evolução funcional após discectomia endoscópica lombar, uma avaliação mais precoce de 32 casos
Authors: Aprile Bruno César , Amato Marcelo Campos Moraes , de Oliveira Cézar Augusto 
Published: March 2020

ResumoObjetivo Determinar o tempo de alta hospitalar e o período de melhora funcional e da dor dos pacientes submetidos a discectomia endoscópica percutânea lombar (DEPL).Métodos Avaliação retrospectiva do tempo de internação e dos questionários escala visual análoga (EVA), índice de incapacidade Oswestry (IIO), e Roland-Morris de 32 pacientes submetidos a DEPL nos períodos pré-operatório e com 2 dias, e 1, 2, 4, 6, e 12 semanas pós-operatórias.Resultados Todos os pacientes receberam alta em menos de 6 horas houve melhora estatística entre o período pré-operatório e 2 dias pós-operatório , sendo o valor médio do questionário EVA axial de 6,63 para 3,31, do EVA irradiado de 6,66 para 2,75, do IIO de 44,59% para 33,17% e do Roland-Morris de 14,03 para 10,34. Tal diferença apresentou melhora progressiva até 12 semanas em todos os questionários. O IIO atingiu valores de incapacidade mínima (19,39%) com 6 semanas de avaliação.Conclusão Todos os 32 pacientes receberam alta hospitalar em até 6 horas. Houve melhora significativa dos sintomas funcionais e de dor já com 48 horas, apresentando ainda melhora adicional significativa e progressiva até o 3° mês.
Mediciones frecuentes en el sistema nervioso central mediante tomografía computada e imágenes de resonancia magnética
Authors: Sartori Pablo , Alvarado Luis , Chirveches María , Urrutia Macarena , Yampolsky Braian 
Published: March 2020

ResumenEn la práctica diaria, durante la realización de informes, suelen presentarse variantes anatómicas, lesiones y diversas patologías del sistema nervioso central (SNC) en las que es necesario realizar algún tipo de mediciones con la finalidad de formular un diagnóstico preciso.Esas mediciones permiten al médico derivante o tratante programar y realizar procedimientos terapéuticos mínimamente invasivos o que requieran una intervención quirúrgica de mayor relevancia.Realizamos una descripción de las mediciones más frecuentes en el SNC empleando tomografía computada (TC) e imágenes de resonancia magnética (RM).
Th17 lymphocytes drive vascular and neuronal deficits in a mouse model of postinfectious autoimmune encephalitis
Authors: Platt Maryann P. , Bolding Kevin A. , Wayne Charlotte R. , Chaudhry Sarah , Cutforth Tyler , Franks Kevin M. , Agalliu Dritan 
Published: March 2020

SignificanceAntibodies against neuronal receptors and synaptic proteins are associated with a group of ill-defined central nervous system (CNS) autoimmune diseases named autoimmune encephalitides (AE), characterized by an abrupt onset of seizures and movement and psychiatric deficits. How these antibodies enter the brain to trigger neuroinflammation, and how they affect the function of neural circuits, remains poorly understood. Here, we demonstrate that Th17 lymphocytes are critical for entry of autoantibodies into the CNS, persistent microglia activation, and neurophysiological deficits in odor processing, in a mouse model of postinfectious autoimmune encephalitis triggered by multiple infections with group AStreptococcus. Our findings emphasize the critical role that Th17 lymphocytes play in disease pathogenesis to impair CNS function in AE syndromes.
Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM
Authors: Cendrowska Urszula , Silva Paulo Jacob , Ait-Bouziad Nadine , Müller Marie , Guven Zekiye Pelin , Vieweg Sophie , Chiki Anass , Radamaker Lynn , Kumar Senthil T. , Fändrich Marcus , Tavanti Francesco , Menziani Maria Cristina , Alexander-Katz Alfredo , Stellacci Francesco , Lashuel Hilal A. 
Published: March 2020

Significance
The ability of proteins to self-assemble into different types of fibrils with distinct morphologies has been linked to the pathological and clinical heterogeneity of amyloid diseases such as Alzheimer’s disease and Parkinson’s disease. Here, we describe nanoparticles (NPs) that efficiently label amyloid fibrils produced in vitro or isolated from postmortem tissues, under hydrating conditions and in such a way as to unmask their polymorphism and morphological features. Using these NPs, we show that pathological aggregates exhibit exceptional morphological homogeneity compared with amyloid fibrils produced in vitro, consistent with the emerging view that the physiologic milieu is a key determinant of amyloid fibril strains. These advances pave the way for elucidating the structural basis of amyloid strains and toxicity.
From semantics to grammar
Authors: Garachana Camarero Mar , Hernández Díaz Axel 
Published: March 2020

Abstract
The main aim of this paper is to analyze the rise of the
Spanish verbal periphrases tener de/que + inf and
investigate the relevance of analogy and lexical semantics for these
changes. We demonstrate that the constructions haber de/que
+ inf acted as supporting constructions motivating
the rise of the synonymous pair tener de/que + inf
(De Smet & Fischer 2017).
The analogical process between the two constructions was due to the synonymy
between the lexical verbs haber and tener
expressing possessive meanings.
Effective pair potential for random fcc CoCrFeMnNi alloys
Authors: Gröger R , Vitek V , Dlouhý A 
Published: March 2020

Abstract
The single-phase equiatomic CoCrFeMnNi alloy is a random solid solution of five elements on the face-centered cubic lattice, whose pure constituents crystallize in very different structures and exhibit diverse magnetic properties. Due to the randomness of the alloy, 80% of nearest neighbor bonds are between unlike elements and thus the details of bonding in pure structures are less important. The elastic moduli of this alloy give rise to small Cauchy pressure C
12 − C
44, which suggests that the dominant part of bonding may be described by a simple pair potential. We test this hypothesis by developing a long-range Lennard-Jones potential in which the equilibrium crystal structures of pure constituents are taken as reference. The standard mixing rules for regular solutions are then adopted to obtain parameters for bonds between unlike elements in the quinary system. The transferability of this potential to quaternary CoCrFeNi, ternary CoCrNi, and binary FeNi alloys is investigated and the predictions compared with experiments and density functional theory calculations. By sampling over a large number of random configurations, we investigate the effect of compositional randomness on misfit volumes, energies of point defects and stacking faults, and the dislocation friction stresses experienced by moving edge and screw dislocations.
Effect of Ti on microstructure and mechanical properties of die-cast Al-Mg-Zn-Si alloy
Authors: Zhang Yu , Yan Feng , Zhao Yu-hong , Song Chun-li , Hou Hua 
Published: March 2020

Abstract
The Al-11.0Mg-2.6Si-4.0Zn-0.6Mn (wt%) alloy is a new developed high strength die cast alloy which can be used for structural parts in the automotive and aerospace industry. In this study, the effect of various amount of Ti on microstructure evolution and mechanical properties of Al-11.0Mg-2.6Si-4.0Zn-0.6Mn (wt%) alloy under as-cast and T6 heat treatment conditions are investigated. The addition of Ti results in the formation of Al3Ti intermetallic phase, and the volume fraction and forming temperature increases with the increase of titanium content. With 0.1wt% Ti addition, the best mechanical properties of the alloy. The yield strength (YS), ultimate tensile strength (UTS) and elongation reach up to 350 MPa, 440 MPa and 3.29% respectively after heat treatment. Titanium content should be controlled below 0.10%.
The comparison of gas tungsten arc welding and flux cored arc welding effects on dual phase steel
Authors: Abbas Mahmoud , Hamdy Ahmed Sayed , Ahmed Essam 
Published: March 2020

Abstract
This work aims to investigate the effects of two welding techniques (gas tungsten arc welding (GTAW) with filler metal ER70S-3 and flux cored arc welding (FCAW) with filler metal E71T1C) on the microstructure and mechanical properties (including softening due to the conversion of martensite into tempered martensite) of DP steels with different martensite volume fractions ranging from 9 to 20%. Microstructure features and the constituents of base metals and heat affected zones of all weldments were examined and analyzed using an optical microscope and a scanning electron microscope integrated with energy-dispersive x-ray spectroscopy. Hardness, tensile, and v-notch impact toughness measurements were also carried out. Visual and radiographic inspection showed that both the FCAW and GTAW techniques produced sound weldments. However, DP steel weldments exhibited softening effects, which led to a decrease in joint efficiency. This decrease were related to transformation of the original martensite into tempered martensite. The results also revealed that the DP steel joints efficiencies are ranged from 85.9 to 87.7% using the FCAW process and ranged from 83.3 to 86% using the GTAW process. The impact toughness of the samples welded by FCAW is higher than the impact toughness of those welded by GTAW due to a higher percentage of acicular ferrite. This information should be valuable in the automotive and other industries, where DP steels are valued for their combination of high strength and ductility, which leads to weight savings and thus to reduced fuel consumption.
The dependence of the strain path on the microstructure, texture and mechanical properties of cryogenic rolled Al-Cu alloy
Authors: Selvan C Chinthanai , Narayanan C Sathiya , Ravisankar B , Narayanasamy R , Valliammai C Thillaiyadi 
Published: March 2020

Abstract
An investigation was conducted on Al-4%Cu alloy sheets to study the role of deformation path on the strength properties, evolution of microstructure and crystallographic texture during cryogenic rolling. Samples were rolled to two distinct thickness strains (50% and 75%) by unidirectional and cross rolling (bidirectional) routes. The strength and hardness properties were found to be more efficient in the cross rolled samples at 50% reduction than their counterparts rolled unidirectionally. Dynamic recovery was observed at higher rolling reductions on cross rolling. Microscopic features observed by EBSD revealed the occurrence of significant grain refinement on the samples rolled with a change of strain path. Also, the alteration of the rolling route resulted in distinct deformation textures and microstructures. TEM studies pointed out the scattered diffusion of the disintegrated dislocation cores and the redistribution of the second phase particles on higher rolling reductions with the change of strain path. Furthermore, the texture results showed a threefold increase on the Goss/Brass ratio which indicated the good fracture toughness behaviour of the cross rolled samples at lower reductions.
Convection and diffusion assisted reactive coupling at incompatible semi-crystalline polymer interfaces
Authors: Barraud T , Devisme S , Hervet H , Brunello D , Klein V , Poulard C , Restagno F , Léger L 
Published: March 2020

Abstract
Based on a specifically designed stretching apparatus, we study the incidence of the stretching parameters on the formation of polypropylene-polyamide-6 (PP-PA6) copolymers acting as adhesion promoters in PP/PA6 multilayer films. The stretching apparatus mimics the stretching conditions found in the air gap of a co-extrusion machine in terms of stretching velocities and distances and of cooling rates. We propose a simplified numerical modeling of these experiments. It allows to explore how the various molecular (concentration in reactive species, diffusion coefficient) and stretching parameters affect the time evolution of the copolymer surface density during stretching. More precisely, we show that even though the contact time for the reaction is large regarding the reaction time, a dilation of the surface can result in a strong lowering of the grafting density at the interface.
Enacting the Locus of Enunciation as a Resistant Tactic to Confront Epistemological Racism and Decolonize Scholarly Knowledge
Authors: Sugiharto Setiono 
Published: March 2020

AbstractThis forum article is an attempt to engage in a recent exchange between Figueiredo and Martinez and Kubota whose articles were published in this journal. Bearing out the tenets of the latter author’s claims regarding how to confront the dominance of white Euro-American hegemonic knowledge, Figueiredo and Martinez proposed an additional insightful way of challenging the dominance of this knowledge, namely by unmasking and exposing one’s own loci of enunciation. I take up the notion of the locus of enunciation further by not just simply conceiving it as a way, but rather as a resistant tactic. Construed in the latter sense, the article argues that scholars from the Global South do not passively and uncritically accept Eurocentric epistemologies as the sole universal and legitimate knowledge. Instead, they are capable of not only negotiating and appropriating the established knowledge, but also performing their agentive capacity from their specific geo-political and body-political positionalities to resist the dominion of Eurocentric epistemological practices, as well as to elevate and legitimate their own ecology of knowledges.
FAME: fast and memory efficient multiple sequences alignment tool through compatible chain of roots
Authors: Naznooshsadat Etminan , Elham Parvinnia , Ali Sharifi-Zarchi 
Published: March 2020

Abstract

Motivation
Multiple sequence alignment (MSA) is important and challenging problem of computational biology. Most of the existing methods can only provide a short length multiple alignments in an acceptable time. Nevertheless, when the researchers confront the genome size in the multiple alignments, the process has required a huge processing space/time. Accordingly, using the method that can align genome size rapidly and precisely has a great effect, especially on the analysis of the very long alignments. Herein, we have proposed an efficient method, called FAME, which vertically divides sequences from the places that they have common areas; then they are arranged in consecutive order. Then these common areas are shifted and placed under each other, and the subsequences between them are aligned using any existing MSA tool.

Results
The results demonstrate that the combination of FAME and the MSA methods and deploying minimizer are capable to be executed on personal computer and finely align long length sequences with much higher sum-of-pair (SP) score compared to the standalone MSA tools. As we select genomic datasets with longer length, the SP score of the combinatorial methods is gradually improved. The calculated computational complexity of methods supports the results in a way that combining FAME and the MSA tools leads to at least four times faster execution on the datasets.

Availability and implementation
The source code and all datasets and run-parameters are accessible free on http://github.com/naznoosh/msa.

Supplementary information
Supplementary data are available at Bioinformatics online.
Projected t-SNE for batch correction
Authors: Aliverti Emanuele , Tilson Jeffrey L , Filer Dayne L , Babcock Benjamin , Colaneri Alejandro , Ocasio Jennifer , Gershon Timothy R , Wilhelmsen Kirk C , Dunson David B 
Published: March 2020

Abstract

Motivation
Low-dimensional representations of high-dimensional data are routinely employed in biomedical research to visualize, interpret and communicate results from different pipelines. In this article, we propose a novel procedure to directly estimate t-SNE embeddings that are not driven by batch effects. Without correction, interesting structure in the data can be obscured by batch effects. The proposed algorithm can therefore significantly aid visualization of high-dimensional data.

Results
The proposed methods are based on linear algebra and constrained optimization, leading to efficient algorithms and fast computation in many high-dimensional settings. Results on artificial single-cell transcription profiling data show that the proposed procedure successfully removes multiple batch effects from t-SNE embeddings, while retaining fundamental information on cell types. When applied to single-cell gene expression data to investigate mouse medulloblastoma, the proposed method successfully removes batches related with mice identifiers and the date of the experiment, while preserving clusters of oligodendrocytes, astrocytes, and endothelial cells and microglia, which are expected to lie in the stroma within or adjacent to the tumours.

Availability and implementation
Source code implementing the proposed approach is available as an R package at https://github.com/emanuelealiverti/BC_tSNE, including a tutorial to reproduce the simulation studies.

Contact
aliverti@stat.unipd.it