bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital health during COVID-19 pandemic and beyond
Authors: Rahman Shah Md Mahfuzur , Hossain Shah Monir , Jahan Mahmood -uz- 
Published: November 2020

Coronavirus disease (COVID-19) was unknown before the outbreak began in Wuhan, China in December 2019. The virus rapidly spread in different countries across the globe. The World Health Organization (WHO) declared it as a pandemic on the 11th March 2020.1 The pandemic has revealed many areas of public health preparedness those are lacking both in developed and developing countries. Digital interventions provide many opportunities for strengthening health systems.2 It could be a vital resources and could play a critical role in global response to this public health emergency.
Digital health is the use of digital information and communication technologies for efficient and timely delivery of health care services, aimed at promoting and protecting the health of the individuals and communities. Furthermore, digital technologies are also being used for conducting monitoring and surveillance of the health programmes, health education, research, development of human resources including continued professional development, risk analysis speacially the risk commucation. Data being generated through services, research, monitoring and surveillance are also used for health management and decision making.
Bangladesh Med Res Counc Bull 2020; 46(2): 66-67
Association of endometrial carcinoma with obesity and diabetes mellitus
Authors: Begum Shirin Akter , Mahmud Tasfia , Amatullah Mehriban 
Published: November 2020

Background: Endometrial cancer, previously referred to as carcinoma of the uterus. The incidence of endometrial cancer is raising, due to improved screening causing fewer hysterectomies in ageing population. Several studies are going on to find out the association and effects between DM and DM-related diseases, especially the cancer. Obesity and physical inactivity plays important role as modifiable determinants of insulin resistance, hyperinsulinaemia and diabetes. All these factors are also responsible for endometrial cancer.
Objectives: To find out the association between endometrial carcinoma with obesity and diabetes mellitus
Methods: This was a cross sectional and observational study, conducted among. 50 consecutive patients admitted as known case of endometrial carcinoma diagnosed by fractional curettage and endometrial biopsy and 50 consecutive patients having other common gynaecological problems in Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from January 2015 to December 2017.
Results: Out of 50 women having endometrial carcinoma, only 4% (n=2) having healthy BMI, 36% (n=18) were overweight, 60% (n=30) were obese. Among 50 healthy women without endometrial carcinoma showed that 4% (n=2) having underweight, 70% (n=35) having healthy BMI, 14% (n=7) having overweight and only 12% (n=6) were obese. Regarding distribution of diabetes mellitus among study population, 50 women having endometrial carcinoma 26 % (n=13) were diabetic and 74% (n=37) were non diabetic.50 healthy women without endometrial carcinoma showed that 8% (n=4) diabetic and 92% (n=46) were non diabetic. Among total 17% (n=17) diabetic patients, 76.5% (n-13) having endometrial carcinoma and 23.5% (n=4) were healthy having no endometrial carcinoma. Among 83% (n=83) women having no diabetes 55.4% (n=46) were healthy having no endometrial carcinoma and 44.6% (n=37) having endometrial carcinoma. Association between Diabetes mellitus and endometrial carcinoma was statistically significant (p=0.017). Having high BMI (overweight, obese) and diabetics had significant elevated risks of endometrial cancer, compared with non-overweight non-diabetic subjects.
Conclusion: Obesity, history of PCOS, physical inactivity and diabetes are the risk factors of endometrial carcinoma. So, it should be treated promptly these diseases to reduce risk factors. Moreover, strengthen public awareness to address these risk factors at earlier to reduce the cancer burden is recommended.
Bangladesh Med Res Counc Bull 2020; 46(2): 120-127
Potential of Soluble Decellularized Extracellular Matrix for Musculoskeletal Tissue Engineering – Comparison of Various Mesenchymal Tissues
Authors: Hanai Hiroto , Jacob George , Nakagawa Shinichi , Tuan Rocky S. , Nakamura Norimasa , Shimomura Kazunori 
Published: November 2020

BackgroundIt is well studied that preparations of decellularized extracellular matrix (ECM) obtained from mesenchymal tissues can function as biological scaffolds to regenerate injured musculoskeletal tissues. Previously, we reported that soluble decellularized ECMs derived from meniscal tissue demonstrated excellent biocompatibility and produced meniscal regenerate with native meniscal anatomy and biochemical characteristics. We therefore hypothesized that decellularized mesenchymal tissue ECMs from various mesenchymal tissues should exhibit tissue-specific bioactivity. The purpose of this study was to test this hypothesis using porcine tissues, for potential applications in musculoskeletal tissue engineering.MethodsNine types of porcine tissue, including cartilage, meniscus, ligament, tendon, muscle, synovium, fat pad, fat, and bone, were decellularized using established methods and solubilized. Although the current trend is to develop tissue specific decellularization protocols, we selected a simple standard protocol across all tissues using Triton X-100 and DNase/RNase after mincing to compare the outcome. The content of sulfated glycosaminoglycan (sGAG) and hydroxyproline were quantified to determine the biochemical composition of each tissue. Along with the concentration of several growth factors, known to be involved in tissue repair and/or maturation, including bFGF, IGF-1, VEGF, and TGF-β1. The effect of soluble ECMs on cell differentiation was explored by combining them with 3D collagen scaffold culturing human synovium derived mesenchymal stem cells (hSMSCs).ResultsThe decellularization of each tissue was performed and confirmed both histologically [hematoxylin and eosin (H&amp;E) and 4’,6-diamidino-2-phenylindole (DAPI) staining] and on the basis of dsDNA quantification. The content of hydroxyproline of each tissue was relatively unchanged during the decellularization process when comparing the native and decellularized tissue. Cartilage and meniscus exhibited a significant decrease in sGAG content. The content of hydroxyproline in meniscus-derived ECM was the highest when compared with other tissues, while sGAG content in cartilage was the highest. Interestingly, a tissue-specific composition of most of the growth factors was measured in each soluble decellularized ECM and specific differentiation potential was particularly evident in cartilage, ligament and bone derived ECMs.ConclusionIn this study, soluble decellularized ECMs exhibited differences based on their tissue of origin and the present results are important going forward in the field of musculoskeletal regeneration therapy.
Seismo-Acoustic Characterization of Mount Cleveland Volcano Explosions
Authors: Iezzi Alexandra M. , Fee David , Haney Matthew M. , Lyons John J. 
Published: November 2020

Volcanic explosions can produce large, ash-rich plumes that pose great hazard to aviation, yet may often have few precursory geophysical signals. Mount Cleveland is one of the most active volcanoes in the Aleutian Arc, Alaska (United States) with at least 65 explosions between December 2011 and June 2020. We characterize the seismo-acoustic signals from explosions at Mount Cleveland over a period of 4 years starting in 2014 when the permanent local instrumentation was installed. While the seismic explosion signals are similar, the acoustic signals vary between explosions. Some explosion acoustic waveforms exhibit a single main compressional phase while other waveforms have multiple compressions. The time lag between seismic and acoustic arrivals varies considerably (up to 2.20 s) at a single station ∼3 km from the vent, suggesting a change in propagation path for the signals between explosions. We apply a variety of methods to explore the potential contributions to this variable time lag from atmospheric conditions, nonlinear propagation, and source depth within the conduit. This variable time lag has been observed elsewhere, but explanations are often unresolved. Our results indicate that while changes in atmospheric conditions can explain some of the variation in acoustic arrival time relative to the seismic signal arrivals, substantial residual time lag variations often still exist. Additionally, nonlinear propagation modeling results do not yield a change in the onset time of the acoustic arrival with source amplitudes comparable to (and larger) than Cleveland explosions. We find that a spectrum of seismic cross-correlation values between events and particle motion dip angles suggests that a varying explosion source depth within the conduit likely plays a dominant role in the observed variations in time lag. Explosion source depths appear to range from very shallow depths down to ∼1.5–2 km. Understanding the seismo-acoustic time lag and the subsequent indication of a variable explosion source depth may help inform explosion source modeling for Mount Cleveland, which remains poorly understood. We show that even with a single co-located seismic and acoustic sensor that does not always remain on scale, it is possible to provide meaningful interpretations of the explosion source depth which may help monitoring agencies understand the volcanic system.
Tetrapropylammonium Hydroxide as a Zinc Dendrite Growth Suppressor for Rechargeable Aqueous Battery
Authors: Kurmanbayeva Indira , Rakhymbay Lunara , Korzhynbayeva Kuralay , Adi Akylbek , Batyrbekuly Dauren , Mentbayeva Almagul , Bakenov Zhumabay 
Published: November 2020

Zinc metal is widely used as an anode in various aqueous systems. However, zinc anode suffers from the dendrite formation on the surface upon cycling leading to a poor cyclability of a cell and its termination due to short circuit. In this work, the effect of tetrapropylammonium hydroxide (TPAH) was studied as an electrolyte additive for aqueous Zn//ZnCl2 + LiCl//LiFePO4 battery. TPAH additive prolongs the battery cycle life depending on its concentration (0.01–0.1 M). The better capacity retention over 350 cycles was observed for a symmetrical Zn//ZnCl2 + LiCl//Zn cell with 0.05 M TPAH whereas without additives the cell worked for only 110 cycles. The mechanism of TPAH influence on capacity retention is proposed based on the results of SEM and XRD analysis of the Zn anode and FTIR and NMR studies of the electrolyte. The XRD patterns of the negative electrode of the cell with TPAH indicates that zinc was preferentially deposited in a highly oriented (002) direction, which is more resistant against dendrite formation. These differences in deposited structure of Zn dendrites were confirmed by SEM images as well. FTIR and NMR spectra showed that TPAH decomposes to propylamine (RnN+H) and propene during cycling. TPAH also has an effect on the size and uniform distribution of Zn growth sides.
Leukotriene A4 Hydrolase Is a Candidate Predictive Biomarker for Successful Allergen Immunotherapy
Authors: Ma Ting-Ting , Cao Meng-Da , Yu Rui-Li , Shi Hai-Yun , Yan Wei-Jun , Liu Jian-Guo , Pan Chen , Sun Jinlyu , Wei Qing-Yu , Wang De-Yun , Wei Ji-Fu , Wang Xue-Yan , Yin Jin-Shu 
Published: November 2020

BackgroundAllergic rhinitis is a common disorder that affects 10% to 40% of the population worldwide. Allergen immunotherapy (AIT) represents the only therapy that has the potential to resolve clinical symptoms of allergic rhinitis. However, up to 30% of patients do not respond to AIT. Biomarkers predicting the clinical efficacy of AIT as early as possible would significantly improve the patient selection and reduce unnecessary societal costs. MethodsArtemisia pollen allergic patients who received at least 1-year AIT were enrolled. Clinical responses before and after 1-year AIT were evaluated to determine AIT responders. Artemisia specific IgE and IgG4 levels were measured by using ImmunoCAP and enzyme-linked immunosorbent assay (ELISA) separately. Stepwise regression analysis was performed to identify which rhinitis-relevant parameters explained the most variability in AIT results. Liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomics was applied to identify the potential candidate biomarkers in the sera of responders and non-responders collected before and after 1-year therapy. The diagnostic performance of the potential biomarkers was then assessed using enzyme-linked immunosorbent assay (ELISA) in 30 responders and 15 non-responders.ResultsArtemisia specific IgE and IgG4 levels were elevated only in the responders. Regression analysis of allergic rhinitis-relevant parameters provided a robust model that included two most significant variables (sneeze and nasal congestion). Thirteen candidate biomarkers were identified for predicting AIT outcomes. Based on their association with allergy and protein fold change (more than 1.1 or less than 0.9), four proteins were identified to be potential biomarkers for predicting effective AIT. However, further ELISA revealed that only leukotriene A4 hydrolase (LTA4H) was consistent with the proteomics data. The LTA4H level in responders increased significantly (P &lt; 0.001) after 1-year therapy, while that of non-responders remained unchanged. Assessment of LTA4H generated area under curve (AUC) value of 0.844 (95% confidence interval: 0.727 to 0.962; P &lt; 0.05) in distinguishing responders from the non-responders, suggesting that serum LTA4H might be a potential biomarker for predicting the efficiency of AIT.ConclusionSerum LTA4H may be a potential biomarker for early prediction of an effective AIT.
Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report
Authors: Cenciarelli Sabina , Calbi Valeria , Barzaghi Federica , Bernardo Maria Ester , Oltolini Chiara , Migliavacca Maddalena , Gallo Vera , Tucci Francesca , Fraschetta Federico , Albertazzi Elena , Fratini Elena Sophia , Consiglieri Giulia , Giannelli Stefania , Dionisio Francesca , Sartirana Claudia , Racca Sara , Camesasca Chiara , Peretto Giovanni , Daverio Rita , Esposito Antonio , De Cobelli Francesco , Silvani Paolo , Rabusin Marco , Cara Andrea , Trabattoni Daria , Dispinseri Stefania , Scarlatti Gabriella , Piemonti Lorenzo , Lampasona Vito , Cicalese Maria Pia , Aiuti Alessandro , Ferrua Francesca 
Published: November 2020

In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and experienced a mild course of infection, with limited inflammatory complications, despite pre-gene therapy clinical phenotype.
Effects of Heat-Treatment on the Microstructure, Electromagnetic Wave Absorbing Properties, and Mechanical Properties of SiCN Fibers
Authors: Long Xin , Zhang Shuai , Shao Changwei , Wang Bing , Wang Yingde 
Published: November 2020

SiCN fibers can not only be used for reinforcement of composites materials but also for electromagnetic wave (EMW) absorbing applications in a high-temperature oxidizing environment above 1,200°C. In this work, the microstructural evolution and EMW absorbing properties of SiCN fibers after annealing at 1,300–1,600°C in N2 atmosphere were investigated. Results showed that the amorphous SiCN fibers presented poor EMW absorbing properties when the annealing temperature was below 1,400°C. As the annealing temperature increased to 1,500°C, the EMW absorbing properties could been largely enhanced with a minimum reflation loss value of -55.8 dB and an effective absorption bandwidth value of 2.5 GHz. The enhanced EMW absorbing properties should contribute to the formation and growth of grain boundaries and defects among the amorphous fiber matrix and turbostratic graphite carbon, which could enhance the space charge polarization at the heterogeneous interfaces and increase the conductivity of the SiCN fibers. Meanwhile, SiCN fibers retained a rather high tensile strength of ∼1.0 GPa after annealing at 1,500°C, which showed it to be a promising candidate for reinforcing the stealth ceramic matrix composites used in harsh environments.
Processing of Sr2+ Containing Poly L-Lactic Acid-Based Hybrid Composites for Additive Manufacturing of Bone Scaffolds
Authors: Melo Priscila , Naseem Raasti , Corvaglia Ilaria , Montalbano Giorgia , Pontremoli Carlotta , Azevedo António , Quadros Paulo , Gentile Piergiorgio , Ferreira Ana Marina , Dalgarno Kenneth , Vitale-Brovarone Chiara , Fiorilli Sonia 
Published: November 2020

Biodegradable composite materials represent one of the major areas of investigation for bone tissue engineering due to their tuneable compositional and mechanical properties, which can potentially mimic those of bone and potentially avoid the removal of implants, mitigating the risks for the patient and reducing the overall clinical costs. In addition, the introduction of additive manufacturing technologies enables a strict control over the final morphological features of the scaffolds. In this scenario, the optimisation of 3D printable resorbable composites, made of biocompatible polymers and osteoinductive inorganic phases, offers the potential to produce a chemically and structurally biomimetic implant, which will resorb over time. The present work focuses on the development and process optimisation of two hybrid composite filaments, to be used as feedstock for the fused filament fabrication 3D printing process. A Poly L-lactic acid matrix was blended with either rod-like nano-hydroxyapatite (nano-HA) or nanoparticles of mesoporous bioactive glasses, both partially substituted with strontium (Sr2+), due to the well-known pro-osteogenic effect of this ion. Both inorganic phases were incorporated into Poly L-lactic acid using an innovative combination of processes, obtaining a homogeneous distribution throughout the polymer whilst preserving their ability to release Sr2+. The filament mechanical properties were not hindered after the incorporation of the inorganic phases, resulting in tensile strengths and moduli within the range of cancellous bone, 50 ± 10 MPa and 3 ± 1 GPa. Finally, the rheological characterization of the hybrid composites indicated a shear thinning behaviour, ideal for the processing with fused filament fabrication, proving the potential of these materials to be processed into 3D structures aiming bone regeneration.
Nomogram for Acute Bilirubin Encephalopathy Risk in Newborns With Extreme Hyperbilirubinemia
Authors: Qu Yangming , Huang Shuhan , Fu Xin , Wang Youping , Wu Hui 
Published: November 2020

Background and Objectives: This work aimed to develop a predictive model of neonatal acute bilirubin encephalopathy.Methods: We retrospectively analyzed the data on extreme hyperbilirubinemia (EHB) newborns hospitalized in the First Hospital of Jilin University from January 1, 2012 to December 31, 2019. The demographic characteristics, pathological information, and admission examination results of newborns were collected to analyze the factors affecting acute bilirubin encephalopathy and to establish a predictive model.Results: A total of 517 newborns were included in this study, of which 102 (19.7%) had acute bilirubin encephalopathy. T1WI hyperintensity [18.819 (8.838–40.069)], mother's age &gt; 35 years [2.618 (1.096–6.2530)], abnormal white blood cell (WBC) [6.503 (0.226–18.994)], TSB level [1.340 (1.242–1.445)], and albumin level [0.812 (0.726–0.907)] were independently associated with neonatal acute bilirubin encephalopathy (ABE). All independently associated risk factors were used to form an ABE risk estimation nomogram. The bootstrap validation method was used to internally validate the resulting model. The nomogram demonstrated good accuracy in predicting the risk of ABE, with an unadjusted C index of 0.943 (95% CI, 0.919–0.962) and a bootstrap-corrected C index of 0.900.Conclusion: A nomogram was constructed using five risk factors of ABE. This model can help clinicians determine the best treatment for neonatal hyperbilirubinemia.
Health Effects of Alternate-Day Fasting in Adults: A Systematic Review and Meta-Analysis
Authors: Cui Yuanshan , Cai Tong , Zhou Zhongbao , Mu Yingmei , Lu Youyi , Gao Zhenli , Wu Jitao , Zhang Yong 
Published: November 2020

Background: Alternate-day fasting (ADF) method is becoming more and more popular among adults. This meta-analysis aims to evaluate the effects of ADF on adults.Methods: Randomized controlled trials (RCTs) of ADF were searched using PubMed (1988 to March 2020), EMBASE (1995 to March 2020), and the Cochrane Controlled Trials Register. A systematic review was carried out using the Preferred Reporting Items for Systematic Reviews and Meta-analyses. The datum was calculated by RevMan version 5.3.0. The original references for relating articles were also reviewed.Results: Seven randomized controlled trials involving 269 participants (152 in the ADF group and 117 in the control group) were studied. In this meta-analysis, compared with the control group, the ADF group showed statistically significant reductions in weight (p &lt; 0.00001) and body mass index (p &lt; 0.00001). Besides, the ADF group showed significant differences in terms of total cholesterol (p = 0.001), low-density lipoprotein (p = 0.01), triglycerides (p = 0.02), fat mass (p = 0.002), lean mass (p = 0.002), systolic blood pressure (p = 0.003), diastolic blood pressure (p = 0.007), and total calorie intake (p = 0.007). At the same time, the analysis demonstrated that the ADF group had a same effect compared with control group in aspects of high-density lipoprotein (p = 0.27), homeostasis model assessment-insulin resistance (p = 0.55), and fasting blood sugar (p = 0.09).Conclusions: This meta-analysis suggests that ADF is a viable diet strategy for weight loss, and it has a substantial improvement in risk indicators for diseases in obese or normal people.