bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulating Telematics Insurance
Authors: van den Boom Freyja 
Published: November 2020

Abstract‘Telematics’ insurance is an example of data driven innovation in the insurance industry where data obtained from the vehicle (such as speed, time and location) is used to provide consumers with premiums based on their actual driving behavior. Despite the many benefits including more accurate risk assessments and premium setting, there are serious privacy concerns about the increased use of vehicle data for insurance purposes. The information requirements of the GDPR and the IDD could address some of these concerns in the context of telematics insurance. This research chapter concludes the analysis of the scope of these requirements by proposing the need for a broad interpretation for information to be made available in order to effectively help consumers make better, well informed decisions about insurance products and use of their personal data for insurance purposes.
IDD and Distribution Risk Management
Authors: Bravo Jorge Miguel 
Published: November 2020

AbstractDistribution is a key aspect of insurers’ business models. Insurance companies use multi-channel and multi touch-point distribution methods to target their customers. Insurers must manage the distribution risk arising from actions of the distribution channel, which have the potential to impact the quality and volume of the insured portfolio, the insurer’s income-generating capacity, long-term financial sustainability and brand value. In this chapter we discuss the implications of the introduction of the Insurance Distribution Directive (IDD) on distribution risk management and on firm’s entire value chain. The expected impact of IDD main provisions (demands and needs analysis, suitability and appropriateness requirements, remuneration and incentive mechanisms, conflicts of interest dispositions, cross-selling, POG, information to customers, CPD) on product development, sales and distribution, underwriting and policy administration, claims, asset and customer management activities are analysed, considering the influence of digitalization on insurance distribution and value chain.
Enaction of Chapter VII of the Insurance Distribution Directive: What Can Member States Learn from the Enforcement Failures of the United States?
Authors: Defever Kathleen M. 
Published: November 2020

AbstractChapter VII of the Insurance Distribution Directive delineates the sanctions and other pecuniary measures which the Commission of the European Union now requires as a portion of the minimum harmonization of the Directive. As Member States adopt and apply the articles of Chapter VII, which are unprecedented in their scope and specificity, they may find guidance through a comparison of the enforcement mechanisms already in place in other jurisdictions.The United States is well known as the largest insurance market in the world, and possesses an extensive body of insurance regulation. The National Association of Insurance Commissioners, an advisory organization comprised of the insurance commissioners from each of the 50 U.S. states, drafted the Producer Licensing Model Act—the closest American corollary to the IDD. Unfortunately, despite widespread adoption of the PLMA, the effectiveness of U.S. state enforcement mechanisms on the actions of intermediaries is, overall, weak and inconsistent. We will analyze why this is the case, and offer concrete examples of the failures of specific state enforcement regimes.
On the data set’s ruins
Authors: Malevé Nicolas 
Published: November 2020

AbstractComputer vision aims to produce an understanding of digital image’s content and the generation or transformation of images through software. Today, a significant amount of computer vision algorithms rely on techniques of machine learning which require large amounts of data assembled in collections, or named data sets. To build these data sets a large population of precarious workers label and classify photographs around the clock at high speed. For computers to learn how to see, a scale articulates macro and micro dimensions: the millions of images culled from the internet with the few milliseconds given to the workers to perform a task for which they are paid a few cents. This paper engages in details with the production of this scale and the labour it relies on: its elaboration. This elaboration does not only require hands and retinas, it also crucially zes mobilises the photographic apparatus. To understand the specific character of the scale created by computer vision scientists, the paper compares it with a previous enterprise of scaling, Malraux’s Le Musée Imaginaire, where photography was used as a device to undo the boundaries of the museum’s collection and open it to an unlimited access to the world’s visual production. Drawing on Douglas Crimp’s argument that the “musée imaginaire”, a hyperbole of the museum, relied simultaneously on the active role of the photographic apparatus for its existence and on its negation, the paper identifies a similar problem in computer vision’s understanding of photography. The double dismissal of the role played by the workers and the agency of the photographic apparatus in the elaboration of computer vision foreground the inherent fragility of the edifice of machine vision and a necessary rethinking of its scale.
Is neuroticism relevant for old cancer survivors? A controlled, population-based study (the Norwegian HUNT-3 survey)
Authors: Grov Ellen Karine , Dahl Alv A. 
Published: November 2020

Abstract
Purpose
Personality traits, particularly neuroticism, have an impact on people’s health and lifestyle. Due to lack of previous studies, we examined old cancer survivors (OCSs) versus cancer-free age-matched controls aged ≥ 70 years, regarding prevalence of high neuroticism, health problems in those with high and low neuroticism, and sociodemographic and clinical variables that were significantly associated with high neuroticism.

Methods
We merged data from a Norwegian population–based health study (the HUNT-3) and from the Cancer Registry of Norway identifying OCSs. Three cancer-free controls were drawn at random for each OCS. Neuroticism was self-rated on a brief version of Eysenck Personality Questionnaire. Between-group statistical comparisons were made between OCS and controls, and among their subgroups with high and low neuroticism. Logistic regression analyses were used to investigate independent variables significantly associated with high neuroticism.

Results
Twenty-nine percent of OCSs reported high neuroticism while controls reported 30%. OCSs showed significantly lower rate of good life satisfaction than controls. All other between-group comparisons were nonsignificant. Being OCSs was not significantly related to high neuroticism in the regression analyses. Sociodemographic, general health, and lifestyle issues, lack of energy, and low life satisfaction remained significantly associated with high neuroticism in the multivariable analysis.

Conclusions
The prevalence of high neuroticism was similar in OCSs and controls. High neuroticism was associated with negative health and lifestyle issues in both groups.
Quality of life and illness perceptions in patients with breast cancer using a fasting mimicking diet as an adjunct to neoadjuvant chemotherapy in the phase 2 DIRECT (BOOG 2013–14) trial
Authors:   on behalf of the Dutch Breast Cancer Research Group (BOOG), Lugtenberg Rieneke T. , de Groot Stefanie , Kaptein Ad A. , Fischer Maarten J. , Kranenbarg Elma Meershoek-Klein , Carpentier Marjolijn Duijm-de , Cohen Danielle , de Graaf Hiltje , Heijns Joan B. , Portielje Johanneke E. A. , van de Wouw Agnes J. , Imholz Alex L. T. , Kessels Lonneke W. , Vrijaldenhoven Suzan , Baars Arnold , Fiocco Marta , van der Hoeven Jacobus J. M. , Gelderblom Hans , Longo Valter D. , Pijl Hanno , Kroep Judith R. 
Published: November 2020

Abstract
Purpose
In the phase II DIRECT study a fasting mimicking diet (FMD) improved the clinical response to neoadjuvant chemotherapy as compared to a regular diet. Quality of Life (QoL) and illness perceptions regarding the possible side effects of chemotherapy and the FMD were secondary outcomes of the trial.

Methods
131 patients with HER2-negative stage II/III breast cancer were recruited, of whom 129 were randomly assigned (1:1) to receive either a fasting mimicking diet (FMD) or their regular diet for 3 days prior to and the day of neoadjuvant chemotherapy. The European Organisation for Research and Treatment of Cancer (EORTC) questionnaires EORTC-QLQ-C30 and EORTC-QLQ-BR23; the Brief Illness Perception Questionnaire (BIPQ) and the Distress Thermometer were used to assess these outcomes at baseline, halfway chemotherapy, before the last cycle of chemotherapy and 6 months after surgery.

Results
Overall QoL and distress scores declined during treatment in both arms and returned to baseline values 6 months after surgery. However, patients’ perceptions differed slightly over time. In particular, patients receiving the FMD were less concerned and had better understanding of the possible adverse effects of their treatment in comparison with patients on a regular diet. Per-protocol analyses yielded better emotional, physical, role, cognitive and social functioning scores as well as lower fatigue, nausea and insomnia symptom scores for patients adherent to the FMD in comparison with non-adherent patients and patients on their regular diet.

Conclusions
FMD as an adjunct to neoadjuvant chemotherapy appears to improve certain QoL and illness perception domains in patients with HER2-negative breast cancer.
Trialregister
ClinicalTrials.gov Identifier: NCT02126449.
Comparing the Effectiveness of Three Different Biorefinery Processes at Recovering Bioactive Products from Hemp (Cannabis sativa L.) Byproduct
Authors: Setti Leonardo , Samaei Seyedeh Parya , Maggiore Irene , Nissen Lorenzo , Gianotti Andrea , Babini Elena 
Published: November 2020

AbstractHemp (Cannabis sativa L.) seeds are considered a nutritional powerhouse, rich in proteins and unsaturated fatty acids. The market for hemp seed food products is growing, due to the loosening of constraints in industrial cultivation. During the food processing chain, the external part of the seed is discarded, although it contains a significant amount of proteins. Converting this material into value-added products with a biorefinery approach could meet the ever-increasing need for sustainable protein sources while reducing food waste. In this study, creating value from hemp byproducts was pursued with three different approaches: (i) chemical extraction followed by enzymatic digestion, (ii) liquid fermentation by strains of Lactobacillus spp., and (iii) solid-state fermentation by Pleurotus ostreatus. The resulting products exhibited a range of in vitro antioxidant and antihypertensive activity, depending on the proteases used for enzymatic digestion, the bacterial strain, and the length of time of the two fermentation processes. These byproducts could be exploited as functional ingredients in the food, pharmaceutical, and cosmetic industries; the suggested biorefinery processes thus represent potential solutions for the development of other protein-containing byproducts or wastes.
Pore structure characterization and its effect on methane adsorption in shale kerogen
Authors: Wang Tian-Yu , Tian Shou-Ceng , Liu Qing-Ling , Li Gen-Sheng , Sheng Mao , Ren Wen-Xi , Zhang Pan-Pan 
Published: November 2020

AbstractPore structure characterization and its effect on methane adsorption on shale kerogen are crucial to understanding the fundamental mechanisms of gas storage, transport, and reserves evaluation. In this study, we use 3D scanning confocal microscopy, scanning electron microscopy (SEM), X-ray nano-computed tomography (nano-CT), and low-pressure N2 adsorption analysis to analyze the pore structures of the shale. Additionally, the adsorption behavior of methane on shales with different pore structures is investigated by molecular simulations. The results show that the SEM image of the shale sample obviously displays four different pore shapes, including slit pore, square pore, triangle pore, and circle pore. The average coordination number is 4.21 and the distribution of coordination numbers demonstrates that pores in the shale have high connectivity. Compared with the adsorption capacity of methane on triangle pores, the adsorption capacity on slit pore, square pore, and circle pore are reduced by 9.86%, 8.55%, and 6.12%, respectively. With increasing pressure, these acute wedges fill in a manner different from the right or obtuse angles in the other pores. This study offers a quantitative understanding of the effect of pore structure on methane adsorption in the shale and provides better insight into the evaluation of gas storage in geologic shale reservoirs.
Habitat, Sexual and Allometric Influences on Morphological Traits of Intertidal Crabs
Authors: Vermeiren P. , Lennard C. , Trave C. 
Published: November 2020

AbstractIntertidal crabs display distinct morphological traits that allow differential interactions with biotic and abiotic features of the intertidal landscape, but are also influenced by allometry and sexual selection. This study aimed to explore the influence of sexual, allometric and habitat factors on morphological variation in the intertidal mangrove crab assemblage. A standardized photographic protocol was developed using readily available, low-cost technology to capture the morphology of carapaces and claws as sets of Cartesian landmarks. Digitization errors were 1 to 2 orders of magnitude smaller than the variation among individuals. InTubuca seismellaandTubuca signata(superfamily Ocypodoidea), species that have traditionally been studied for sexual dimorphism, standardized major claw sizes were 2.8 and 3.7, respectively, times larger for males than females. Sexual dimorphism in claw size was also observed forMetopograpsus frontalisandParasesarma longicristatum(superfamily Grapsoidea), with the largest claw in males being 15% and 33%, respectively, larger than in females. In contrast to size, claw shape did not relate to sex, except forT.seismella.Carapace shape, although variable among individuals and displaying asymmetry, was unrelated to sex. Claw and carapace shapes displayed high correlations, with values around 0.78. Carapace shapes grouped into taxonomic families and linked to habitat preferences, while claw shapes varied along a taxonomic gradient. These results complement studies on crab morphology that focus on specific factors or species, and stress the importance of multiple, interacting factors including sexual, allometric and habitat influences as drivers of morphological trait variability.
Sonothrombolysis in the ambulance for ST-elevation myocardial infarction: rationale and protocol
Authors: El Kadi S. , Porter T. R. , van Rossum A. C. , Kamp O. 
Published: November 2020

AbstractBackgroundTreatment of ST-elevation myocardial infarction (STEMI) has improved over the years. Current challenges in the management of STEMI are achievement of early reperfusion and the prevention of microvascular injury. Sonothrombolysis has emerged as a potential treatment for acute myocardial infarction, both for epicardial recanalisation as well as improving microvascular perfusion. This study aims to determine safety and feasibility of sonothrombolysis application in STEMI patients in the ambulance.MethodsTen patients with STEMI will be included and treated with sonothrombolysis in the ambulance during transfer to the PCI centre. Safety will be assessed by the occurrence of ventricular arrhythmias and shock during sonothrombolysis intervention. Feasibility will be assessed by the extent of protocol completion and myocardial visibility. Efficacy will be determined by angiographic patency rate, ST-elevation resolution, infarct size and left ventricular volumes, and function measured with cardiovascular magnetic resonance imaging, and contrast and strain echocardiography. A comparison will be made with matched controls using an existing STEMI database.DiscussionSonothrombolysis is a novel technique for the treatment of cardiovascular thromboembolic disease. The first clinical trials on its use for STEMI have demonstrated promising results. This study will be the first to examine the feasibility of in-ambulance sonothrombolysis for STEMI.Trial registrationEU Clinical Trials Register (identifier: 2019-001883-31), registered 2020-02-25.
A molecular phylogeny ofPilocarpaceaeZahlbr., including a new species ofTapellariaMüll. Arg. and new records of foliicolous lichenized fungi from Thailand
Authors: Wang Wei-Cheng , Sangvichien Ek , Wei Tie-Zheng , Wei Jiang-Chun 
Published: November 2020

AbstractThe phylogeny of foliicolous taxa inPilocarpaceaewas reconstructed using Bayesian and maximum likelihood analyses of concatenated ITS and mtSSU sequences. Sixty-six new partial sequences representing 36 taxa were generated and 29 sequences were downloaded from GenBank. Our results indicate thatLasiolomaR. Sant. is nested within a paraphyleticCalopadiaVězda, whereasFellhaneraVězda is polyphyletic and the phylogenetic relationships ofEugeniellaLückinget al. andSporopodiumMont. withFellhanerarequire further investigation. In addition,Tapellaria parvimuriformisW. C. Wang & J. C. Wei is described as a new species from Khao Yai National Park, Thailand, and is characterized by its small muriform ascospores, grey campylidia with a pale base, and short conidia. Eight new records of foliicolous lichens for Thailand are also listed.
The corruption–growth relationship: does the political regime matter?
Authors: Saha Shrabani , Sen Kunal 
Published: November 2020

AbstractCorruption is widely believed to have an adverse effect on the economic performance of a country. However, many East-and-Southeast-Asian countries either achieved or currently are achieving impressively rapid economic growth despite widespread corruption – the so-called East-Asian-Paradox. A common feature of these countries was that they were autocracies. We re-examine the corruption-growth relationship, in light of the East-Asian-Paradox. We examine the role of political regimes, in mediating corruption–growth relationship using panel data over 100 countries for the period 1984–2016. We find clear evidence that corruption–growth relationship differs by the type of political regime, and the growth-enhancing effect of corruption is more likely in autocracies than in democracies. The marginal effect analysis shows that in strongly autocratic countries, higher corruption may lead to significantly higher growth, while this is not the case in democracies. Alternatively, democracy is not good for growth if there is a high level of perceived corruption. We provide suggestive evidence that the mechanism by which corruption is growth-enhancing in autocracies is through the perceived credibility of the commitment of ruling political elites to economic freedom, thereby providing confidence to the firms to invest, leading to long-term growth.
Isotropic and Anisotropic P Wave Velocity Structures of the Crust and Uppermost Mantle Beneath Turkey
Authors: Wang Haibo , Huang Zhouchuan , Eken Tuna , Keleş Derya , Kaya‐Eken Tulay , Confal Judith M. , Erman Ceyhun , Yolsal‐Çevikbilen Seda , Zhao Dapeng , Taymaz Tuncay 
Published: November 2020

AbstractCompressional and extensional tectonics following northward plate convergences since the Miocene have formed the major surface features in Turkey, such as faulting and orogeny. Despite increasing efforts in last few decades aiming to elucidate the current architecture of the crust and mantle beneath Turkey, several issues regarding the depth extent of the deformation zones, crust‐mantle interaction (e.g., coupling and decoupling) in relation to the deformation, and stress transmission in the lithosphere remain elusive. Here we present high‐resolution 3‐D P wave isotropic and azimuthal anisotropic velocity models of the crust and uppermost mantle beneath Turkey by inverting 204,531 P wave arrival times of 8,103 local crustal earthquakes. Our results reveal low‐velocity anomalies or velocity contrasts down to the uppermost mantle along the North and East Anatolian Fault Zones. The fast velocity directions (FVDs) of azimuthal anisotropy in the lower crust and uppermost mantle are parallel to the regional maximum extensional directions in western Turkey, and the FVDs in the crust and uppermost mantle are parallel to the surface structures in southeastern Turkey. These results indicate that vertically coherent deformation between the crust and uppermost mantle occurs in western and southeastern Turkey. However, in central northern Turkey, the FVDs in the uppermost mantle are oblique to both the FVDs in the lower crust and the maximum shear directions derived from GPS measurements, suggesting that the crust and lithospheric mantle are decoupled there.
Vagus nerve stimulation optimized cardiomyocyte phenotype, sarcomere organization and energy metabolism in infarcted heart through FoxO3A-VEGF signaling
Authors: Luo Bin , Wu Yan , Liu Shu-lin , Li Xing-yuan , Zhu Hong-rui , Zhang Lei , Zheng Fei , Liu Xiao-yao , Guo Ling-yun , Wang Lu , Song Hong-xian , Lv Yan-xia , Cheng Zhong-shan , Chen Shi-you , Wang Jia-ning , Tang Jun-ming 
Published: November 2020

AbstractVagus nerve stimulation (VNS) restores autonomic balance, suppresses inflammation action and minimizes cardiomyocyte injury. However, little knowledge is known about the VNS’ role in cardiomyocyte phenotype, sarcomere organization, and energy metabolism of infarcted hearts. VNS in vivo and acetylcholine (ACh) in vitro optimized the levels of α/β-MHC and α-Actinin positive sarcomere organization in cardiomyocytes while reducing F-actin assembly of cardiomyocytes. Consistently, ACh improved glucose uptake while decreasing lipid deposition in myocytes, correlating both with the increase of Glut4 and CPT1α and the decrease of PDK4 in infarcted hearts in vivo and myocytes in vitro, attributing to improvement in both glycolysis by VEGF-A and lipid uptake by VEGF-B in response to Ach. This led to increased ATP levels accompanied by the repaired mitochondrial function and the decreased oxygen consumption. Functionally, VNS improved the left ventricular performance. In contrast, ACh-m/nAChR inhibitor or knockdown of VEGF-A/B by shRNA powerfully abrogated these effects mediated by VNS. On mechanism, ACh decreased the levels of nuclear translocation of FoxO3A in myocytes due to phosphorylation of FoxO3A by activating AKT. FoxO3A overexpression or knockdown could reverse the specific effects of ACh on the expression of VEGF-A/B, α/β-MHC, Glut4, and CPT1α, sarcomere organization, glucose uptake and ATP production. Taken together, VNS optimized cardiomyocytes sarcomere organization and energy metabolism to improve heart function of the infarcted heart during the process of delaying and/or blocking the switch from compensated hypertrophy to decompensated heart failure, which were associated with activation of both P13K/AKT-FoxO3A-VEGF-A/B signaling cascade.