bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Critical Role for Immune System-released Activating Agent (Israa) in the Ontogenetic Development of the Brain
Authors: Al-Awadi Aminah M. I. , AlJawder Abdulaziz Isa , Mousa Alyaa , Taha Safa , Bakhiet Moiz 
Published: May 2020

Abstract
Background: The Immune System-Released Activating Agent (ISRAA) was discovered as a novel molecule that functions as a mediator between the nervous and immune systems in response to a nervous stimulus following an immune challenge. Thisresearch investigated the role ofISRAA)in promoting the ontogeny of the mouse brain. Methods: Astrocyte cultures were prepared from two-month-old BALB/c mice. Recombinant ISRAA protein was used to stimulate astrocyte cultures. Immunohistochemistry and ELISA were utilized to measure ISRAA andIFN-g levels, IFN-gR expression and STAT1 nuclear translocation. MTT-assay was used to evaluate cellular survival and proliferation. To assess astrocyte cell lysates and tyrosine-phosphorylated proteins, SDS-PAGE and western blot were used.Results: ISRAA was highly expressed in mouse embryonic astrocytes,depending on cell age. Astrocytes agedseven days (E7) showed increased proliferation and diminisheddifferentiation, while 21-day-old (E21)astrocytes depictedreversed effects. ISRAAstimulated the tyrosine phosphorylation of numerous cellular proteins and thenuclear translocation of STAT1. IFN-g was vital for ISRAAactionas ISRAA induced IFN-gin both age groups, but only E21 astrocytes expressed IFN-gR. Conclusion: The results suggest that ISRAA is cruciallyinvolved in mouse brain development through the cytokine network involving IFN-g.
What’s the “Secret Sauce”? How Implementation Variation Affects the Success of Colorectal Cancer Screening Outreach
Authors: Coury Jennifer , Miech Edward J. , Styer Patricia , Petrik Amanda F. , Coates Kelly E. , Green Beverly B. , Baldwin Laura-Mae , Shapiro Jean A. , Coronado Gloria 
Published: May 2020

Abstract
Background Mailed fecal immunochemical testing (FIT) programs can improve colorectal cancer (CRC) screening rates, but health systems often vary implementation (i.e., adapt) these programs for their organizations. A health insurance plan implemented a mailed FIT program (named BeneFIT) and allowed participating health systems to adapt the program. This mixed-methods study explored which program adaptations might have achieved higher screening rates.Methods We used a multi-method approach. First, we conducted a descriptive analysis of CRC screening rates by key health system characteristics and program adaptations. Second, we applied Configurational Comparative Methods (CCMs) to determine potential explanatory factors consistent with higher screening rates. The main outcome measure was CRC screening rates.Results Seventeen health systems took part in at least one year of BeneFIT. The overall screening completion rate was 20% (4–28%) in Year 1, and 25% (12–35%) in Year 2 of the program. Health systems that used two or more adaptations had higher screening rates, and no single adaptation clearly led to higher screening rates. In Year 1, smaller systems (having < 2 clinics) with phone reminders (n = 2) met the implementation success threshold (≥ 19% screening rate) while larger systems were successful when offering a patient incentive (n = 4), scrubbing mailing lists (n = 4), or allowing mailed FIT returns with no other adaptations (n = 1). In Year 2, large systems (> 2 clinics) were successful with a phone reminder (n = 4) or a patient incentive (n = 3). Of the 10 systems that implemented BeneFIT in both years, seven improved in Year 2.Conclusions Health systems can choose between many adaptations and successfully implement a health plan’s mailed FIT program. Screening completion rates are positively associated with the number of adaptations implemented by a health system. Health system size emerged as an important contextual factor, with different solutions for larger than smaller health systems.Contributions to the Literature· Our paper analyzes adaptations that enable health care providers to implement mailed fecal immunochemical testing (FIT) programs in delivery systems.· Our results explore which adaptations made by health systems to mailed FIT programs are related to screening rate improvements. Our analysis shows that a health system’s organizational characteristics in combination with the adaptations themselves may affect resulting CRC screening rates and implementation.· Our paper describes different pathways that health care organizations can use to implement CRC screening outreach to improve the health of their populations. We show results of implementation flexibility and customizing CRC screening outreach to particular clinic environments.
A Risk Signature with Immune and Inflammatory Cells Infiltration in Gastric Cancer Predicts Survival and Efficiency of Chemotherapy
Authors: Li Sen , Wang Wenpeng , Ma Pengfei , Zhang Junli , Cao Yanghui , Liu Chenyu , Zhang Xijie , Chen Li , Song Shubing , Li Zhiguo , Zhao Yuzhou 
Published: May 2020

Abstract
Background In order to accurately predict outcomes of gastric cancer (GC), we developed a risk signature with tumor infiltration immune and inflammatory cells for prognosis.Methods A risk signature model in combination with CD66b + neutrophils, CD3 + T, CD8 + T lymphocytes, and FOXP3 + regulatory T cells was developed in a training cohort of 327 GC patients undergoing surgical resection between 2011 and 2012, and validated in a validation cohort of 285 patients from 2012 to 2013.Results High CD66b expression predicted poor disease-special survival (DSS) as well as inversely correlated with CD8 (P < 0.05) and FOXP3 expression (P < 0.05) in the training cohort, comparable disease-free survival (DFS) findings were observed in the validation cohort.Furthermore, a risk stratification was developed from integration of CD66b + neutrophils and T immune cells. In both DFS and DSS, the high-risk group all demonstrated worse prognosis than low-risk group in both the training cohort and the validation cohort (all P < 0.05). In addition, the high-risk group was associated with post-operative relapses. Furthermore, this risk signature model increase the predictive accuracy and efficiency for post-operative relapses. At last, the high-risk group identified a subgroup of GC patients who tend to not benefit from adjuvant chemotherapy.Conclusions Incorporation of neutrophils into T lymphocytes could provide more accurate prognostic information in GC, and this risk stratification predicted survival benefit from post-operative adjuvant chemotherapy in GC.
Development and psychometric properties of the HBM- based Substance Abuse Prevention Questionnaire (HBM-SAPQA) among Afghanian students
Authors: Mohammadi Kanali , Tavafian Sedigheh sadat , Tavousi Mahmoud 
Published: May 2020

Abstract
Background
In Afghanistan, adolescents and young people are the most important at risk groups for substance abuse. Considering the importance of model-based interventions, this study aims to design and validate a questionnaire based on the Health Belief Model (HBM) for assessing the beliefs of Afghan students regarding substance abuse prevention behavior.
Methods
This study was conducted in two stages. Firstly, the items of the questionnaire were designed by conducting a combined documentary literature review and qualitative study. In the next step, its psychometric properties were evaluated through qualitative and quantitative formal validity (calculation of impact score), qualitative and quantitative content validity - Content Validity Ratio (CVR) and Content Validity Index (CVI)- and structural validity through Factor Explanatory Analysis (FEA). Finally, consistency compatibility through Cronbach’s alpha as well as reliability (internal correlation) test re-test were assessed. To above steps, the SPSS version 18 was applied.
R esults
74 items were obtained for the questionnaire by performing a qualitative study and using existing scientific sources for literature review. In the study of formal validity of quantitative items, the effect coefficient of all above 1.5 was calculated. The CVR of each item was more than 0.8 (mean 0.93), and their CVI was more than 0.79. In this stage, 12 items related to cues to action hanged to 1 item with 12 options so all 63 remained items were retained in the questionnaire. In FEA 40 items related to main constructs of HBM were assessed by which, by eliminating 2 items, structural validity was confirmed for 38 items in 5 factors and covering about 40% of the variance for EFA 408 students with average age of 23 years old were assessed. In the internal compatibility process, the acceptable values ​​of Cronbach's alpha between 0.71 and 0.81 were calculated for all factors. Test re test approved to assess reliability of the instrument.
Conclusion
The HBM-SAPQA tool obtained the acceptable validity/reliability to apply the beliefs of Afghan students regarding substance abuse preventive behavior. Although the result of this study showed, this questionnaire has good validity and reliability, but this result should be confirmed in future studies.
Secure Massive MIMO System with Two-Way Relay Cooperative Transmission in 6G Networks
Authors: Su Yumeng , Gao Hongyuan , Zhang Shibo 
Published: May 2020

Abstract
With the advent of Internet of Everything (IoE) and the era of big data, massive multiple-input multiple-output (MIMO) is considered an essential technology to meet the growing communication requirements for beyond 5G and the forthcoming 6G networks. This paper considers a secure massive MIMO system, where the legitimate user and the base station (BS) exchange messages via two-way relays with the presence of passive eavesdroppers. To achieve the trade-off between the physical-layer security and communication reliability, we design a cooperative transmission mode based on multiple-relay collaboration, where some relays broadcast the received signals and other relays act as friendly jammers to prevent the interception by eavesdroppers. A quantum chemical reaction optimization (QCRO) algorithm is proposed to find the most suitable scheme for multiple-relay collaboration. Simulation results highlight excellent performance of the proposed transmission mode under QCRO in different communication scenarios, which can be considered a potential solution for the security issue in future wireless networks.
Association between non-motor symptoms and health-related quality of life for patients with Parkinson’s disease: Evidence from a smartphone-based survey
Authors: Fan Xiaojing , Zhao Yaxin , Luo Huanyuan , James Ben , Wang Duolao , Hellman Bruce 
Published: May 2020

Abstract
Background

This study aims to explore the association between the total number of non-motor symptoms and the Parkinson’s disease (PD) patients’ health-related quality of life quantitatively, using data from one of the largest smartphone-powered studies and a simplified version of 8-item Parkinson’s disease Quality of life Questionnaire (PDQ-8).
Methods

The data used for analysis constitutes one part of a dataset derived from the project named ‘100 for Parkinson’s’, an initiative of uMotif in conjunction with the Cure Parkinson’s Trust, Parkinson’s UK and the European Parkinson’s Disease Association. 1246 patients were included in the baseline survey. The 30-item Non-Motor Symptom (NMS-30) Questionnaire and PDQ-8 Summary Index (PDQ-8 SI) were used to measure health-related quality of life and a generalized linear model was used to analyze the association of the non-motor symptoms and quality of life.
Results

The mean number of NMS per patient was 11.81 ± 5.53. For patients with limited ability to work: the key symptoms were urgency (77.4%), sad or blue (71.05%) and difficulty getting to sleep or staying asleep (70.90%). After controlling for the life-style determinants and psychological symptoms prior PD diagnosis determinants, GLM presented the total sum of NMS-30 questions had the strongest positive influence on health-related quality of life as measured by the PDQ-8 SI. Where the sum of NMS scores increases by 1 point, the PDQ-8 SI will increase by 1.33 points (95%CI: 1.13, 1.52; P < 0.001). For patients without limited ability to work: urgency (62.45%), difficulty getting to sleep or staying asleep (59.81%) and getting up regularly at night to pass urine (55.09%) were the most frequent symptoms. GLM showed that where the total sum of NMS scores increases by 1 point, the PDQ-8 SI will increase by 1.56 points (95%CI: 1.37, 1.76; P < 0.001) after controlling for other confounders.
Conclusions

This smartphone-based study finds a higher total number of non-motor symptoms is related to a lower health-related quality of life for PD patients. It provides useful evidence for the PDQ-8 instrument and is helpful for a multidisciplinary approach to patient care and facilitate the provision of more comprehensive education for patients and caregivers.
Rectus Sheath Block Efficacy for Patients Who Underwent Emergency Midline Laparotomy at a Resource Limited Setting in Northcentral Ethiopia, 2019.
Authors: Teshome Diriba , Fenta Efrem , Hunie Metages , Girma Sossina 
Published: May 2020

Abstract
Background Midline laparotomy is associated with severe postoperative pain. Literature showed controversial results regarding the efficacy of the rectus sheath block. Objective To assess the effectiveness of rectus sheath block efficacy for patients who underwent emergency midline laparotomy at a resource limited setting in Northcentral Ethiopia, from February 01 to March 30, 2019. Methods This is a prospective cohort study that recruits 60 patients who underwent emergency midline laparotomy. Independent t-test and Manny Whitney tests were used for numeric data while Chi-Square or Fisher exact test was used for categorical variables. P-values < 0.05 were considered as statistically significant. Results The median (interquartile range) of the numeric rating scale score at the recovery was 3(3-4) for an exposed group and 4.5(3-4.5) for an unexposed group with a p-value of 0.039. Postoperative numeric rating scale scores at 3 rd , 6 th , 12 th , and 24 th hours were statistically significantly lower in the exposed group. Postoperative tramadol consumption in 24 hours was significantly lower with a p-value of 0.0001 for the rectus sheath group. Conclusions For surgeries done through midline laparotomy, adding bilateral rectus sheath block (BRSB) at the end of the operation might be an effective postoperative analgesia option.
A retrospective clinical control study of extended anterolateral approach and Frosch approach in Schatzker type II tibial plateau fractures involving the posterolateral column
Authors: Yan Yongqing , Xu Renjie , Yuan Xinhua 
Published: May 2020

Abstract
Objective: To compare the extended anterolateral approach with the Frosch approach in the treatment of Schatzker type II tibial plateau fractures involving the posterolateral column. Methods: A retrospective case-control study was conducted to compare the general information, intraoperative and postoperative situations, HSS score and Rasmussen radiology score, TPA, and PSA immediately after the operation and at one-year follow-up.Results: There was no statistical difference between the two groups in general information, which was comparable. The operation time in the Frosch group was slightly higher than those in the control group, while the HSS score and Rasmussen radiology score were better than those in the control group.Conclusion: In the case with simple posterolateral fragments, the extended anterolateral approach and the Frosch approach can both achieve better outcomes. While in the case of complex posterolateral fragments, the Frosch approach can provide more accurate reduction and better biomechanical stability.
Coeruptive crustal deformation associated with the 2018 Kusatsu-Shirane phreatic eruption based on PALSAR-2 time-series analysis
Authors: Himematsu Yuji , Ozawa Taku , Aoki Yosuke 
Published: May 2020

Abstract
Coeruptive deformation helps to interpret physical processes associated with volcanic eruptions. Because phreatic eruptions cause small, localized coeruptive deformation, we sometimes fail to identify plausible deformation signals. Satellite synthetic aperture radar (SAR) data allow us to identify extensive deformation fields with high spatial resolutions. Herein, we report coeruptive crustal deformation associated with the 2018 Kusatsu-Shirane phreatic eruption detected by time series analyses of L-band satellite SAR (ALOS-2/PALSAR-2) data. Coeruptive deformation maps derived from SAR time series analyses show that subsidence and eastward displacement dominate the southwestern side of an eruptive crater with a spatial extent of approximately 2 km in diameter. Although we were unable to identify any significant deformation signals before the 2018 eruption, posteruptive deformation on the southwestern side of the crater has been ongoing until the end of 2019. This prolonged deformation implies the progression of posteruptive physical processes within a confined hydrothermal system, such as volcanic fluid discharge, similar to the processes observed during the 2014 Ontake eruption. Although accumulated snow and dense vegetation hinder the detection of deformation signals on Kusatsu-Shirane volcano using conventional InSAR data, L-band SAR with various temporal baselines allowed us to successfully extract both coeruptive and posteruptive deformation signals. The extracted coeruptive deformation events are well explained by normal faulting with a left-lateral slip component along a southwest-dipping fault plane rather than by a point source deflation. The inferred fault plane can be considered as a degassing pathway from the shallow hydrothermal system to the surface. We reconfirmed that SAR data is a robust tool for detecting coeruptive and posteruptive deformations, which are helpful for understanding shallow physical processes associated with phreatic eruptions at active volcanoes.
Primary Research ADAM10 is involved in the oncogenic process and chemo-resistance of triple-negative breast cancer via regulating Notch1 signaling pathway, CD44 and PrPc
Authors: Cheng Yuanyuan , Lin Lishuang , Li Xiaoyan , Lu Aiqi , Hou Chenjian , Wu Qian , Hu Xiaomu , Zhou Zhongwen , Chen ZhongQing , Tang Feng 
Published: May 2020

Abstract
Background
Triple-negative breast cancer (TNBC) is the most challenging breast cancer subtype to treat, generally more aggressive and with shorter overall survival. Chemotherapy remains the standard treatment due to the absence of specific and effective molecular targets. The aim of the present study was to investigate the potential roles of A Disintegrin and Metalloproteinase 10 (ADAM10) in TNBC cells and the relationship between ADAM10 expression and neoadjuvant chemotherapy treatment (NACT) effect and overall survival in breast cancer patients.
Methods
Using a series of breast cancer cell lines, we measured the expression of ADAM10 and its substrates by quantitative real-time PCR assay (qRT-PCR) and Western blot analysis. Cell migration and invasion, cell proliferation, drug sensitivity assay, cell cycle and apoptosis were conducted in MDA-MB-231 cells cultured with ADAM10 siRNA. The effect of ADAM10 down-regulation by siRNA on its substrates was assessed by Western blot analysis. We performed immunohistochemical staining for ADAM10 in clinical breast cancer tissues from 94 patients receiving NACT.
Results
The active form of ADAM10 was highly expressed in TNBC cell lines. Knockdown of ADAM10 in MDA-MB-231 cells led to a significant decrease in cell proliferation, migration, invasion and the IC50 value of paclitaxel and adriamycin, while induced cell cycle arrest and apoptosis. And these changes were correlated with down-regulation of Notch signaling, CD44 and PrPc. In clinical breast cancer cases, high ADAM10 expression in pre-NACT samples was strongly associated with poor response to NACT and short overall survival.
Conclusions
These data suggest previously unrecognized roles for ADAM10 in TNBC, involving in the progression and chemo-resistance of TNBC.
Association between objectively measured sleep timing and habitual dietary intake in university students A cross-sectional study
Authors: Yoshizaki Takahiro , Togo Fumiharu 
Published: May 2020

Abstract
Background Previous studies suggest that the forced changes in sleep timing and chronotype may be associated with dietary intake. However, no studies have examined associations between objectively measured sleep timing on weekdays and weekends and habitual dietary intake. This study aimed to investigate the associations among university students. Methods All the 35 healthy university students included in this study were asked to undertake a 7-day wrist activity recording, and to record the bedtimes and wake-up times. All the participants also completed a self-administered questionnaire during the recording period that included demographic characteristics, habitual dietary intakes, and morningness-eveningness. Dietary intakes over the previous 1 month were evaluated using a self-reported dietary history questionnaire (DHQ). The Japanese version of the Morningness-Eveningness Questionnaire (MEQ) was used to measure the self-rated morningness-eveningness. The score for adherence to the Japanese Food Guide Spinning Top (food guide score) was calculated from the results of the DHQ to assess the diet quality. Nocturnal sleep timing on each night was estimated from the recorded wrist activity. Results Multivariate linear regression showed that a later sleep timing on weekends was significantly (p < 0.05) associated with lower intakes of pulses (β = −0.416) and dairy products (β = −0.396) and a lower food guide score (β = −0.386), while the relative sleep timing on weekdays was not (p > 0.05). Multivariate linear regression also showed that an earlier relative sleep timing on weekdays was significantly (p < 0.05) associated with a lower intake of cereals (β = 0.548) and a higher intake of sugar and confectioneries (β = −0.461), while the sleep timing on weekends was not (p > 0.05). Conclusions The results suggest that later sleep timing on weekends and earlier relative sleep timing on weekdays may be independently associated with unfavorable food intake in young adults. These findings have important implications for the development of novel strategies for improving dietary intakes and for preventing lifestyle-related diseases.
Hardship in the Heartland: Associations Between Rurality, Income, and Material Hardship
Authors: Conrad Aislinn , Ronnenberg Megan 
Published: May 2020

Abstract
Approximately one in three US households have experienced material hardship, including food, healthcare access and transportation hardship. The inadequate or unstable provision of basic needs is more typical in households with children or persons of color and is associated with numerous negative outcomes. Little is known, however, about the relationship between rurality, income, and material hardship. Using data from the 2016 State Innovation Model (SIM) Statewide Consumer Survey (weighted N = 2,371,739), we used logistic regression to examine the association between rurality, income, and four forms of material hardship, including food hardship, healthcare access hardship, transportation hardship, and any material hardship. Rural respondents had higher odds than non-rural respondents for experiencing healthcare access hardship. In contrast, rural respondents incurred lower odds than non-rural respondents for experiencing food hardship, transportation hardship and any hardship. All models of hardship indicated that lower income respondents incurred greater odds for having material hardship.