bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring indirect impact of COVID-19 pandemic on services for cardiovascular diseases in the UK
Authors: Ball Simon , Banerjee Amitava , Berry Colin , Boyle Jonathan R , Bray Benjamin , Bradlow William , Chaudhry Afzal , Crawley Rikki , Danesh John , Denniston Alastair , Falter Florian , Figueroa Jonine D , Hall Christopher , Hemingway Harry , Jefferson Emily , Johnson Tom , King Graham , Lee Kuan Ken , McKean Paul , Mason Suzanne , Mills Nicholas L , Pearson Ewen , Pirmohamed Munir , Poon Michael T C , Priedon Rouven , Shah Anoop , Sofat Reecha , Sterne Jonathan A C , Strachan Fiona E , Sudlow Cathie L M , Szarka Zsolt , Whiteley William , Wyatt Michael 
Published: October 2020

ObjectiveTo monitor hospital activity for presentation, diagnosis and treatment of cardiovascular diseases during the COVID-19) pandemic to inform on indirect effects.MethodsRetrospective serial cross-sectional study in nine UK hospitals using hospital activity data from 28 October 2019 (pre-COVID-19) to 10 May 2020 (pre-easing of lockdown) and for the same weeks during 2018–2019. We analysed aggregate data for selected cardiovascular diseases before and during the epidemic. We produced an online visualisation tool to enable near real-time monitoring of trends.ResultsAcross nine hospitals, total admissions and emergency department (ED) attendances decreased after lockdown (23 March 2020) by 57.9% (57.1%–58.6%) and 52.9% (52.2%–53.5%), respectively, compared with the previous year. Activity for cardiac, cerebrovascular and other vascular conditions started to decline 1–2 weeks before lockdown and fell by 31%–88% after lockdown, with the greatest reductions observed for coronary artery bypass grafts, carotid endarterectomy, aortic aneurysm repair and peripheral arterial disease procedures. Compared with before the first UK COVID-19 (31 January 2020), activity declined across diseases and specialties between the first case and lockdown (total ED attendances relative reduction (RR) 0.94, 0.93–0.95; total hospital admissions RR 0.96, 0.95–0.97) and after lockdown (attendances RR 0.63, 0.62–0.64; admissions RR 0.59, 0.57–0.60). There was limited recovery towards usual levels of some activities from mid-April 2020.ConclusionsSubstantial reductions in total and cardiovascular activities are likely to contribute to a major burden of indirect effects of the pandemic, suggesting they should be monitored and mitigated urgently.
CD47/SIRPα blocking peptide identification and synergistic effect with irradiation for cancer immunotherapy
Authors: Wang Hongfei , Sun Yixuan , Zhou Xiuman , Chen Chunxia , Jiao Ling , Li Wanqiong , Gou Shanshan , Li Yanying , Du Jiangfeng , Chen Guanyu , Zhai Wenjie , Wu Yahong , Qi Yuanming , Gao Yanfeng 
Published: October 2020

BackgroundImmunotherapy has achieved remarkable advances via a variety of strategies against tumor cells that evade immune surveillance. As important innate immune cells, macrophages play important roles in maintaining homeostasis, preventing pathogen invasion, resisting tumor cells and promoting adaptive immune response. CD47 is found to be overexpressed on tumor cells and act as a don’t eat me’ signal, which contributes to immune evasion. Macrophages mediated phagocytosis via blockade CD47/SIRPα (signal regulatory protein alpha) interaction was proved to induce effective antitumor immune response.MethodsA novel peptide pep-20, specifically targeting CD47 and blocking CD47/SIRPα interaction, was identified via high-throughput phage display library bio-panning. The capability to enhance the macrophage-mediated phagocytosis activities and antitumor effects of pep-20 were investigated. The mechanism of pep-20 to induce T-cell response was explored by ex vivo analysis and confirmed via macrophage depleting strategy. The structure-activity relationship and D-amino acid substitution of pep-20 were also studied. The antitumor effects and mechanism of a proteolysis resistant D-amino acid derivate pep-20-D12 combined with irradiation (IR) were also investigated.ResultsPep-20 showed remarkable enhancement of macrophage-mediated phagocytosis to both solid and hematologic tumor cells in vitro, and inhibited tumor growth in immune-competent tumor-bearing mice. Furthermore, pep-20 promoted macrophages to mobilize the antitumor T-cell response with minimal toxicity. Furthermore, systemic administration of the derivate pep-20-D12 showed robust synergistic antitumor efficacy in combination with IR.ConclusionIn summary, these results demonstrated that CD47/SIRPα blocking peptides, pep-20 and its derivate, could serve as promising candidates to promote macrophages-mediated phagocytosis and immune response in cancer immunotherapy.
Non-invasive dye dilution method for measuring an atrial septal defect shunt size
Authors: Muroke Valtteri , Jalanko Mikko , Simonen Piia , Holmström Miia , Ventilä Markku , Sinisalo Juha 
Published: October 2020

AimsObjective of this study was to evaluate the feasibility of the non-invasive dye dilution method to quantify shunt size related to atrial septal defects (ASD).The diagnostic accuracy of shunt size determination in ASD’s has been suboptimal with common non-invasive methods. We have previously developed a cost-effective and time-effective non-invasive dye dilution method. In this method, the indocyanine green solution is injected into the antecubital vein and the appearance of the dye is detected with an earpiece densitometer.Methods and resultsWe studied 192 patients with an ASD. Mean pulmonary blood flow/systemic blood flow (Qp/Qs) was measured with dye dilution technique and compared with following methods: Fick’s invasive oximetry (n=49), transoesophageal echocardiography (TEE) measuring ASD size (n=143) and cardiac MR (CMR) (n=9).For the first 49 patients, Qp/Qs was 2.05±0.70 with the Fick’s invasive oximetry and 2.12±0.68 with dye dilution method with an excellent correlation between the two methods (R=0.902, p<0.001). In the second study sample, the ASD size by TEE was 15±6 mm on average, and the mean Qp/Qs 2.16±0.65 measured with dye dilution method with a good correlation between the methods (R=0.674, p<0.001). Qp/Qs measured with CMR was 1.87±0.40 resulting in a good correlation with the dye dilution method (R=0.696, p=0.037).ConclusionThe dye dilution method with earpiece densitometer recording is a clinically feasible and reliable method to assess shunt size in ASDs.
Presence of mitral stenosis is a risk factor of new development of acute decompensated heart failure early after transcatheter aortic valve implantation
Authors: Okai Tsukasa , Mizutani Kazuki , Hara Masahiko , Yamaguchi Tomohiro , Ogawa Mana , Ito Asahiro , Iwata Shinichi , Izumiya Yasuhiro , Takahashi Yosuke , Shibata Toshihiko , Yoshiyama Minoru 
Published: October 2020

AimsAcute decompensated heart failure (ADHF) can occur early after transcatheter aortic valve implantation (TAVI), but the risk factors or mechanisms associated with it have not been fully determined. This hypothesis-generating study aimed to investigate the clinical indices associated with the development of ADHF within 72 hours after TAVI and to improve procedural approaches for TAVI.Method and resultsIn this single-centre hypothesis generating prospective observational study, we enrolled 156 consecutive patients with severe aortic stenosis who underwent TAVI between January 2016 and February 2018 at our institution. We set the primary endpoint as the new development of ADHF within 72 hours after TAVI, and clinical indices associated with it were evaluated using a multivariable logistic model. The median age of the patients was 83 (quartile range 80–86) years, 48 (30.8%) were men and the median Society of Thoracic Surgery-Predicted Risk of Mortality was 7.1 (range 5.2–10.4). Mitral stenosis (MS), defined as mean transmitral valve pressure gradient ≥5 mm Hg, was present in 15 (9.6%) patients. After TAVI, the invasive mean transaortic valve pressure gradient (mAVPG) decreased from 48 (36–66) to 7 (5–11) mm Hg, and 12 (7.7%) patients developed ADHF within 72 hours after TAVI. Multivariable logistic regression analysis showed that MS (adjusted OR, 14.227; 95% CI 2.654 to 86.698; p=0.002) and greater decreases in mAVPG (1.038; 1.003 to 1.080; p=0.044) were associated with ADHF.ConclusionsMS and drastic improvement of mAVPG were associated with new development of ADHF within 72 hours after TAVI.
Toward an Axiomatization of Strongly Possible Functional Dependencies
Authors: Alattar Munqath , Sali Attila 
Published: October 2020

In general, there are two main approaches to handle the missing data values problem in SQL tables. One is to ignore or remove any record with some missing data values. The other approach is to fill or impute the missing data with new values [A. Farhangfar, L. A. Kurgan and W. Pedrycz, A novel framework for imputation of missing values in databases, IEEE Trans. Syst. Man Cybern. A, Syst. Hum. 37(5) (2007) 692–709]. In this paper, the second method is considered. Possible worlds, possible and certain keys, and weak and strong functional dependencies were introduced in Refs. 4 and 2 [H. Köhler, U. Leck, S. Link and X. Zhou, Possible and certain keys for SQL, VLDB J. 25(4) (2016) 571–596; M. Levene and G. Loizou, Axiomatisation of functional dependencies in incomplete relations, Theor. Comput. Sci. 206(1) (1998) 283–300]. We introduced the intermediate concept of strongly possible worlds in a preceding paper, which are obtained by filling missing data values with values already existing in the table. Using strongly possible worlds, strongly possible keys and strongly possible functional dependencies (spFDs) were introduced in Refs. 5 and 1 [M. Alattar and A. Sali, Keys in relational databases with nulls and bounded domains, in ADBIS 2019: Advances in Databases and Information Systems, Lecture Notes in Computer Science, Vol. 11695 (Springer, Cham, 2019), pp. 33–50; Functional dependencies in incomplete databases with limited domains, in FoiKS 2020: Foundations of Information and Knowledge Systems, Lecture Notes in Computer Science, Vol. 12012 (Springer, Cham, 2020), pp. 1–21]. In this paper, some axioms and rules for strongly possible functional dependencies are provided, These axioms and rules form the basis for a possible axiomatization of spFDs. For that, we analyze which weak/strong functional dependency and certain functional dependency axioms remain sound for strongly possible functional dependencies, and for the axioms that are not sound, we give appropriate modifications for soundness.
Exploiting Replication Stress as a Novel Therapeutic Intervention
Authors: Martin Jeffrey C. , Hoegel Tamara J. , Lynch Miranda L. , Woloszynska Anna , Melendy Thomas , Ohm Joyce E. 
Published: October 2020

AbstractEwing sarcoma is an aggressive pediatric tumor of the bone and soft tissue. The current standard of care is radiation and chemotherapy, and patients generally lack targeted therapies. One of the defining molecular features of this tumor type is the presence of significantly elevated levels of replication stress as compared with both normal cells and many other types of cancers, but the source of this stress is poorly understood. Tumors that harbor elevated levels of replication stress rely on the replication stress and DNA damage response pathways to retain viability. Understanding the source of the replication stress in Ewing sarcoma may reveal novel therapeutic targets. Ewing sarcomagenesis is complex, and in this review, we discuss the current state of our knowledge regarding elevated replication stress and the DNA damage response in Ewing sarcoma, one contributor to the disease process. We will also describe how these pathways are being successfully targeted therapeutically in other tumor types, and discuss possible novel, evidence-based therapeutic interventions in Ewing sarcoma. We hope that this consolidation will spark investigations that uncover new therapeutic targets and lead to the development of better treatment options for patients with Ewing sarcoma.Implications:This review uncovers new therapeutic targets in Ewing sarcoma and highlights replication stress as an exploitable vulnerability across multiple cancers.
Unveiling the trap-nesting bees and wasps’ fauna (Hymenoptera: Apocrita) and associated organisms of the Jardim Botânico do Rio de Janeiro, Brazil
Authors: Marinho Diego , Vivallo Felipe 
Published: October 2020

Urban areas, as cities, are frequently overlooked as refuges for the native fauna. However, these places may support several species and house relevant biodiversity contributing to important ecosystemic functions. Wasps and bees (Hymenoptera: Apocrita) are important faunistic elements acting as predators/parasitoids and pollinators, respectively. Therefore, they must be surveyed and inventoried for conservation purposes, especially in cities located in the Atlantic Forest domain, a ravaged Brazilian biome. Accordingly, this study presents a species list of trap-nesting bees and wasps that occurs at the Jardim Botânico do Rio de Janeiro. The survey was conducted using the trap-nest method. Three types of trap-nests were offered totalizing 1,038 traps: rubber hose, bamboo cane and plastic straw. The plastic straw traps were the most effective followed by the bamboo cane ones at attracting nesting wasps and bees. Between April/2017 and February/2019, 12 foundress species built nests: Tetrapedia curvitarsis (Apidae) (33 nests), Hylaeus sp. (Colletidae) (6), Auplopus cf. rufipes (Pompilidae) (5), Trypoxylon sp. (Crabronidae) (4), Pachodynerus nasidens (Vespidae) (3), Auplopus cf. brasiliensis (Pompilidae), Megachile benigna and Megachile sp. (Megachilidae), Euglossa pleosticta, Euglossa sp., and Eufriesea sp. (Apidae) and Penepodium sp. (Sphecidae) all with one nest. Also, four natural enemies were recorded: Chaenotetrastichus neotropicalis (Eulophidae), Gasteruption brachychaetum (Gasterupteiidae), Caenochrysis crotonis (Chrysididae) and Amobia sp. (Diptera: Sarcophagidae). Most bee nests were restrained to the matrix forest and nearby areas, whereas wasps built their nests predominantly in open areas. Regarding seasonality, bees tended to nest in the summer and early autumn influenced by mean temperature, in contrast of wasps that nested in late autumn, winter and spring, influenced by pluviosity. Besides many rare species, which suggests environmental disturbance, the Jardim Botânico do Rio de Janeiro showed a fairly diverse fauna and shows how forest fragment in cities may harbour important representatives of the native fauna.
Perceived Threat of a Linguistic Community and Context Effect on Attitude toward Immigration in Hong Kong
Authors: Lee Francis L.F. , Liang Hai 
Published: October 2020

Abstract
Typically grounded in a discussion of contact vs. threat theory, much research has examined the impact of the presence of ethnic minorities in residential contexts on people’s attitude toward immigration. Yet, there has not been much evidence regarding whether the presence of a linguistically-defined minority can create similar impact under specific political conditions. This article examines Hong Kong, where the arrival of immigrants from mainland China has aroused controversies. The presence of Mandarin speakers, under the contemporary conditions, could be perceived as representing the cultural threat posed by China onto the city. Data from representative surveys were combined with district-level census data. The analysis shows that people living in a district with higher proportions of residents using Mandarin as the usual spoken language indeed favored more restrictive immigration policies. Contextual presence of Mandarin speakers also moderated the impact of tolerance and holding of negative stereotypes on attitude toward immigration.
Sultanates and the Making of Nationhood in Indonesia and Malaysia
Authors: Ikhwan Hakimul , Aidulsyah Fachri 
Published: October 2020

Abstract
This paper seeks to answer the question of how the sultanates of Malaysia maintained their authority in the current nation-state era as almost all of Indonesia’s hundreds of sultanates (except for the Sultanate of Yogyakarta in Java) lost formal power. It proposes three findings. First, Dutch and British colonialism had different legacies in Indonesia and Malaysia, respectively. Second, following their independence, Indonesia and Malaysia adopted different government systems, with the former becoming a unitary republic and the latter becoming a federal state; consequently, the sultanates of Indonesia had to submit themselves to the central government in Indonesia, whereas those in Malaysia were given broader space to exercise their authority within a federal state. Third, the sultanates of Malaysia have a two-layered identity, resulting from the convergence of ethnic Malay and Islamic identities that eventually strengthened the Sultanate’s authority and legitimacy in the eyes of the people and the federal state; conversely, convergence between ethnic and religious identity was limited in Indonesia’s sultanates, subsequently undermining the sultans’ ability to uphold authority and power.
Queering Emotion in South Asia
Authors: Mishra Jayaprakash 
Published: October 2020

Abstract
A paucity of scholarship on emotions in South Asia through a queer lens prevails, as the field is relatively new, and thus, majorly normative. Discussions around emotions, particularly guilt, remain heteronormative. The act of queering emotion not only challenges the dominant gendered affective discourse, but also proposes an alternative framework to understand and elucidate emotions pertinent to queer lives in South Asia. The study analysed ethnographic accounts of 32 gay men from the Eastern Indian state of Odisha. The objectives of this study are threefold. One, it examines the validity of the hypothesis that guilt among gay men is not just an internal orientation, but can be induced by people’s complicitous actions. Two, it uncovers how guilt based on “reciprocity” is roused among gay men in a social system (Lebra, 1971). Society urges gay men to repay their parents, siblings, and caretakers by fulfilling their heteronormative expectations. Three, it foregrounds how gay men respond when apprised of their indebtedness to individuals. The study examines emotions in South Asia through a queer lens by investigating the complex manner in which the queer subjects negotiate with their affectual spaces, viz. social institutions of family and other alternative kinship structures.
Bronze and Gold
Authors: Forcada Miquel 
Published: October 2020

Abstract
Al-Fārābī wrote about the status of medicine in many of his works, and his definition of medicine as a productive art influenced many later scholars. This definition demystified a philosophized conception of medicine that was current among the first physicians of Islam. However, al-Fārābī’s discourse is by no means unambiguous. He says that medicine may be a science, an art, and an art that may be composite, practical, stochastic and not self-sufficient. The article analyzes the textual basis of al-Fārābī’s discourse on medicine and its most salient references and influences, in connection with al-Fārābī’s understanding of Aristotle’s scientific method.
Characteristics of Tropopause Polar Vortices Based on Observations over the Greenland Ice Sheet
Authors: Borg Sarah M. , Cavallo Steven M. , Turner David D. 
Published: October 2020

AbstractTropopause polar vortices (TPVs) are long-lived, coherent vortices that are based on the dynamic tropopause and characterized by potential vorticity anomalies. TPVs exist primarily in the Arctic, with potential impacts ranging from surface cyclone generation and Rossby wave interactions to dynamic changes in sea ice. Previous analyses have focused on model output indicating the importance of clear-sky and cloud-top radiative cooling in the maintenance and evolution of TPVs, but no studies have focused on local observations to confirm or deny these results. This study uses cloud and atmospheric state observations from Summit Station, Greenland, combined with single-column experiments using the Rapid Radiative Transfer Model to investigate the effects of clear-sky, ice-only, and all-sky radiative cooling on TPV intensification. The ground-based observing system combined with temperature and humidity profiles from the European Centre for Medium-Range Weather Forecasts’s fifth major global reanalysis dataset, which assimilates the twice-daily soundings launched at Summit, provides novel details of local characteristics of TPVs. Longwave radiative contributions to TPV diabatic intensity changes are analyzed with these resources, starting with a case study focusing on observed cloud properties and associated radiative effects, followed by a composite study used to evaluate observed results alongside previously simulated results. Stronger versus weaker vertical gradients in anomalous clear-sky radiative heating rates, contributing to Ertel potential vorticity changes, are associated with strengthening versus weakening TPVs. Results show that clouds are sometimes influential in the intensification of a TPV, and composite results share many similarities to modeling studies in terms of atmospheric state and radiative structure.
How Well Can Land-Surface Models Represent the Diurnal Cycle of Turbulent Heat Fluxes?
Authors: Renner Maik , Kleidon Axel , Clark Martyn , Nijssen Bart , Heidkamp Marvin , Best Martin , Abramowitz Gab 
Published: October 2020

AbstractThe diurnal cycle of solar radiation represents the strongest energetic forcing and dominates the exchange of heat and mass of the land surface with the atmosphere. This diurnal heat redistribution represents a core of land–atmosphere coupling that should be accurately represented in land surface models (LSMs), which are critical parts of weather and climate models. We employ a diagnostic model evaluation approach using a signature-based metric that describes the diurnal variation of heat fluxes. The metric is obtained by decomposing the diurnal variation of surface heat fluxes into their direct response and the phase lag to incoming solar radiation. We employ the output of 13 different LSMs driven with meteorological forcing of 20 FLUXNET sites (PLUMBER dataset). All LSMs show a poor representation of the evaporative fraction and thus the diurnal magnitude of the sensible and latent heat flux under cloud-free conditions. In addition, we find that the diurnal phase of both heat fluxes is poorly represented. The best performing model only reproduces 33% of the evaluated evaporative conditions across the sites. The poor performance of the diurnal cycle of turbulent heat exchange appears to be linked to how models solve for the surface energy balance and redistribute heat into the subsurface. We conclude that a systematic evaluation of diurnal signatures is likely to help to improve the simulated diurnal cycle, better represent land–atmosphere interactions, and therefore improve simulations of the near-surface climate.
Export Similarity Index as a Barometer of Indian Textiles Exports Competitiveness
Authors: Kanupriya  
Published: October 2020

This study examines the performance of Indian textiles exports in a relative and holistic framework. Given the pre-eminence of the sector for India’s exports, a comparative study on its performance is called for. For the purpose, India’s key competitors in the export product categories are deduced. The primary objective of this study is to critically assess the Indian textiles exports performance using the export similarity index (ESI). Overall, the study arrives at some important conclusions with regard to this objective using the ESI for the textiles product codes HS 56–60 for the period 2013–2017. In view of the much-needed scope for improvement in the Indian textiles exports performance, there is a need to evolve a comprehensive export strategy for the sector, involving both firm- and state-led efforts so as to have a beneficent impact on exports and the overall Indian economy. JEL Codes: F10, F14, L67