bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sea surface phytoplankton community response to nutrient and light changes
Authors: Mustaffa Nur Ili Hamizah , Kallajoki Liisa , Hillebrand Helmut , Wurl Oliver , Striebel Maren 
Published: August 2020

AbstractThe sea surface microlayer (SML) is the boundary layer between the ocean and the atmosphere and plays a unique role in marine biogeochemistry. Phytoplankton communities in this uppermost surface layer are exposed to extreme ultraviolet (UV) radiation and potentially high nutrient supplies. In order to understand the response of SML communities to such contrasting conditions, we conducted experiments at three different sites, the North Sea (open ocean) and two sites, outer and middle fjord, in the Sognefjord, Norway, with differing physical and chemical parameters. We manipulated light, nitrogen (N) and phosphorus (P) supply to natural communities collected from the SML and compared their response to that of the underlying water (ULW) communities at 1-m depth. Phytoplankton communities in both SML and ULW responded significantly to N addition, suggesting the upper 1-m surface phytoplankton communities were N-limited. While phytoplankton growth rates were higher with high N and high light supply, biomass yield was higher under low light conditions and with a combined N and P supply. Furthermore, biomass yield was generally higher in the ULW communities compared to SML communities. Nutrient and light effects on phytoplankton growth rates, particulate organic carbon (POC) and stoichiometry varied with geographical location. Phytoplankton growth rates in both SML and ULW at the open ocean station, the site with highest salinity, did not respond to light changes, whereas the communities in the middle fjord, characterized by high turbidity and low salinity, did experience light limitation. This work on the upper surface phytoplankton communities provides new insights into possible effects of coastal darkening and increases understanding of oceanic biogeochemical cycling.
The Efficacy of Neoadjuvant Versus Adjuvant Therapy for Resectable Esophageal Cancer Patients: A Systematic Review and Meta‐Analysis
Authors: Xiao Xin , Hong Hyokyoung G. , Zeng Xiaoxi , Yang Yu‐Shang , Luan Si‐Yuan , Li Yi , Chen Long‐Qi , Yuan Yong 
Published: August 2020

AbstractObjectiveInconclusive results are available as to whether chemo/radiotherapy should be administered to resectable esophageal cancer patients before surgery (neoadjuvant therapy) or after surgery (adjuvant therapy). The paper, via a meta‐analysis of effects of treatment modalities when administering chemo/radiotherapy, aims to systematically evaluate the effect of timing of chemo/radiotherapy and surgery.MethodsWe performed a systematic literature search for clinical trials of neoadjuvant and adjuvant therapy for patients with esophageal cancer. Using meta‐analysis, we conducted direct and adjusted indirect comparisons of overall survival, complete resection rate (R0 resection), perioperative mortality, leakage rate and local recurrence in patients with resectable esophageal cancer.ResultsA total of 32 studies involving 7985 patients with esophageal cancer were included in the meta‐analysis. Twenty‐five randomized controlled studies indirectly compared neoadjuvant/adjuvant therapy with surgery alone, while five non‐randomized controlled studies and two randomized controlled studies directly compared neoadjuvant with adjuvant therapy. Neoadjuvant therapy followed by surgery, compared with surgery along with adjuvant therapy, showed a significant overall survival advantage in our pooled analysis (HR 0.88; 95% CI 0.79–0.98). Directly compared with adjuvant therapy, neoadjuvant therapy demonstrated a lower local recurrence rate (OR 0.56; 95% CI 0.43–0.74) with low heterogeneity (I2 = 1%). Neoadjuvant therapy, comparing to surgery with or without adjuvant therapy, showed a significantly higher R0 resection rate (OR 2.86; 95% CI 2.02–4.04) with moderate heterogeneity (I2 = 38%) and no significant differences in postoperative anastomotic leakage (P = 0.50). However, neoadjuvant therapy, compared with surgery adjuvant therapy, significantly increased perioperative mortality in both direct and indirect comparisons (P < 0.01).ConclusionsWe found that neoadjuvant therapy was associated with higher overall survival and R0 resection rate without increasing postoperative anastomotic leakage for patients with resectable esophageal cancer, whereas neoadjuvant therapy was associated with higher perioperative mortality after esophagectomy.
Effect of high-fat diet on the pharmacokinetics and safety of flumatinib in healthy Chinese subjects
Authors: Kuang Yun , Song Hui-ling , Yang Guo-ping , Pei Qi , Yang Xiao-yan , Ye Ling , Yang Shuang , Wu Shu-ting , Guo Can , He Qing-nan , Huang Jie 
Published: August 2020

Abstract
Purpose
To evaluate the effect of a high-fat diet on the pharmacokinetics and safety of flumatinib mesylate tablets in healthy Chinese subjects.

Methods
This study was a randomized, open-label, single-dose, two-period crossover trial in which subjects were randomly assigned to take 400 mg of flumatinib mesylate after a high-fat diet or a fasted state. After a 14-day washout period, the two groups were administered flumatinib mesylate under opposite conditions. Blood samples were collected at baseline 0 and 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8, 10, 12, 24, 48, 72, and 96 h, respectively. Plasma concentrations of flumatinib and its metabolites (M1 and M3) were analyzed using liquid chromatography-mass spectrometry. Pharmacokinetic parameters were calculated using the non-compartmental module of the Phoenix WinNonlin Version 7.0 software. BE module of WinNonLin was used for statistical analysis of AUC0–t, AUC0–∞ and Cmax in plasma.

Results
Twelve healthy subjects, half male and half female, were enrolled. One subject withdrew due to a treatment-emergent adverse event. Eleven subjects were administered drugs on fasting and 12 were administered drugs after a high-fat diet. On high-fat diet/fasting, the least square geometric mean (LSGM) ratios of flumatinib, M1, M3, and their 90% confidence interval (CI) were as follows: for flumatinib, Cmax, AUC0–t and AUC0–∞ were 281.65% (225.80–351.31%), 167.43% (143.92–194.79%), and 166.87% (143.47–194.09%); for M1, Cmax, AUC0–t, and AUC0–∞ were 188.59% (145.29–244.79), 163.94% (149.11–180.24%), and 164.48% (150.36–179.94%); for M3, Cmax, AUC0–t, and AUC0–∞ were 63.47% (54.02–74.57%), 85.23% (74.72–97.22%), and 96.73% (86.63–108.02%).

Conclusion
Among the subjects, oral administration of 400 mg of flumatinib was safe and well tolerated. High-fat diet significantly increases the exposure to flumatinib, therefore, fasting may be recommended.

Clinical trial registration
The study was registered at chictr.org Identifier: ChiCTR-IIR-17013179.
Crop cultivation of Middle Yayoi culture communities (fourth century bce–first century ce) in the Kanto region, eastern Japan, inferred from a radiocarbon-dated archaeobotanical record
Authors: Leipe Christian , Endo Eiko , Kuramochi Shunsuke , Wagner Mayke , Tarasov Pavel E. 
Published: August 2020

AbstractAMS-dated archaeobotanical assemblages from hearth deposits of Middle Yayoi (fourth century bce–first century ce) cultural layers of the Maenakanishi site (36°09′N, 139°24′E) in northern Saitama Prefecture demonstrate that besides rice, foxtail and broomcorn millet were the most important staple crops during the second and first centuries bce. The reliance on less demanding dry-field crops at Maenakanishi and other Early to Middle Yayoi settlements in north-western Kanto and the Central Highlands in eastern central Japan contrasts with concurrent agricultural production in western and north-eastern (Tohoku) Japan, where rice cultivation generally dominated and millets apparently played a minor role. Two factors, which likely influenced this pattern, are the uneven density distribution and the cultural heterogeneity of indigenous non-agricultural Jomon populations during the formation and spread of the Yayoi culture (tenth/fourth century bce–250 ce) brought to the Japanese islands by farmers from the Asian mainland. In western Japan the spread of rice cultivation was likely promoted by low Jomon population densities. The higher importance of foxtail and broomcorn millet at Maenakanishi may be explained by cultural influence from the northern Central Highlands. Early agricultural communities in this region appear to have preferred these newcomer crops that required less labour and organisational efforts.
Management of colorectal anastomotic stricture with multidiameter balloon dilation: long-term results
Authors: Chan R.-H. , Lin S.-C. , Chen P.-C. , Lin W.-T. , Wu C.-H. , Lee J.-C. , Lin B.-W. 
Published: August 2020

Abstract
Background
Postoperative colorectal anastomotic strictures are quite common. As such, many techniques have been available to address such a problem, one of which is endoscopic dilation. The aim of the present study was to evaluate the long-term outcomes following endoscopic dilation using a multidiameter balloon.

Methods
A retrospective study was conducted on patients with postoperative anastomotic stenosis treated with endoscopic dilation using a multidiameter balloon at our institution, in January 2005–December 2019 were retrospectively reviewed, excluding those with tumor recurrence. Perioperative factors, complications, and recurrence rates were analyzed.

Results
There were 40 patients, (22 males and 18 females, mean age 64.6 ± 10.7 years, range 33–84 years). The median follow-up period was 56 months (interquartile range 22.5–99 months). Only 1 complication occurred, micro-perforation due to guided wire injury, which was managed conservatively. Five (12.5%) patients developed restenosis and underwent repeat balloon dilation. None of the five recurrences required more aggressive management, such as redo anastomosis.

Conclusions
Endoscopic multidiameter balloon dilation is a safe and effective method for treating benign colorectal anastomotic strictures.
Evaluation of current solid waste disposal site based on socio-economic and geospatial data: a case study of Wolkite town, Ethiopia
Authors: Weldeyohanis Yenenesh Hailu , Aneseyee Abreham Berta , Sodango Terefe Hanchiso 
Published: August 2020

AbstractWolkite is a town like many developing countries, faces problems associated with poor solid waste management. The town has only one major landfill site, which is found at Gasore kebele, near to the town. However, the waste dumping in this site has been affecting the surrounding community. The objectives of this study were to evaluate the current solid waste deposal site and socioeconomic impact of the current solid waste disposal site in the study area. The data were collected through field observation, key informant interview, focus group discussion, and household survey. Geospatial data were also used to evaluate the current solid disposal site. In this study, fifty-two household and two focus group discussion were participated. The quantitative data coded and analyzed using SPSS software. The data described using descriptive statistics and qualitative data were also expressed using narrative description whereas the geospatial data were analyzed by ArcGIS. The study result showed that the landfill site is proximate to stream and river, church, mosque, rural settlement, main road, and vegetation. The disposal site has affecting negatively to the local community; besides, the municipal waste is disposed arbitrarily on open field, roadside, dumped everywhere and solid waste disposed jointly with liquid at the landfill site, therefore, this study recommends to select suitable landfill site in the of the town.
Coming to Terms with Technoscience: The Heideggerian Way
Authors: Zwart Hub 
Published: August 2020

AbstractHeidegger’s oeuvre (> 100 volumes) contains a plethora of comments on contemporary science, or rathertechnosciencebecause, according to Heidegger, science is inherently technical. What insights can be derived from such comments for philosophers questioning technoscience as it is practiced today? Can Heidegger’s thoughts become a source of inspiration for contemporary scholars who are confronted with automated sequencing machines, magnetic resonance imaging machines and other technoscientific contrivances? This is closely related to the question of method, I will argue. Although Heidegger himself was notoriously ambivalent when it came to method, especially in his later writings, his oeuvre nonetheless contains important hints for how a philosophical questioning of technoscience could be practiced, such as: paying attention to language (to the words that we use) or taking a step backwards (towards the moment of commencement of the type of rationality at work). For Heidegger, method means: being underway, and a philosophical method must be developed along the way. After discussing Heidegger’s views on method, both in his earlier and in his later writings, three dimensions of contemporary technoscience will be addressed, namely: technoscientific objects (research artefacts), technoscientific sites (laboratories as unworldly environments) and technoscience as a global enterprise. In the final section, the question will be addressed whether and how a critical encounter between philosophy and technoscience is possible.
The Case Against Factorism: On the Labels of $$\otimes$$-Factor Hilbert-Spaces of Similar Particles in Quantum Mechanics
Authors: Muller F. A. , Leegwater Gijs 
Published: August 2020

AbstractWe discuss the case against Factorism, which is the standard assumption in quantum mechanics that the labels of the $$\otimes$$
⊗
-factor Hilbert-spaces in direct-product Hilbert-spaces of composite physical systems of similar particles refer to particles, either directly or descriptively. We distinguish different versions of Factorism and argue for their truth or falsehood. In particular, by introducing the concepts of snapshot Hilbert-space and Schrödinger-movie, we demonstrate that there are Hilbert-spaces and $$\otimes$$
⊗
-factorisations where the labels do refer, even descriptively, to similar particles, which renders them probabilistically absolutely discernible.
Abilities in the blind spot of testing regimes: Eliciting the benefits and the limitations of participatory research approaches for numeracy in adult basic education
Authors: Curdt Wiebke , Schreiber-Barsch Silke 
Published: August 2020

AbstractIn the past decade, the numeracy component in adult basic education has gained scholarly attention. The issue has been addressed by large-scale assessments of adults’ skills and intergovernmental policy agendas, but also by qualitative research into numeracy from the perspective of social practice theory. However, some aspects of numeracy are still under-researched. This article argues that adults withlearning difficulties(also referred to by some asintellectual disabilities) and their numeracy-related abilities are still hidden in the blind spot of large-scale testing regimes. To address this underrepresentation, the authors present an overview of the key paradigms of a global testing culture, outline their two areas of interest, disability and numeracy, and identify the blind spots of large-scale international surveys. They consider ways of extending the range of methodological approaches to investigating (literacy and) numeracy, and opt for a participatory research approach, for which they identify five guiding principles. They showcase and reflect on these guiding principles by presenting selected data from a small-scale qualitative study on numeracy practices of adults with learning difficulties. Their aim is to demonstrate the benefits and limitations of using participatory research approaches in the context of investigating numeracy amongallmembers of a country’s adult population.
Are Italian research assessment exercises size-biased?
Authors: Demetrescu Camil , Ribichini Andrea , Schaerf Marco 
Published: August 2020

AbstractResearch assessment exercises have enjoyed ever-increasing popularity in many countries in recent years, both as a method to guide public funds allocation and as a validation tool for adopted research support policies. Italy’s most recently completed evaluation effort (VQR 2011–14) required each university to submit to the Ministry for Education, University, and Research (MIUR) 2 research products per author (3 in the case of other research institutions), chosen in such a way that the same product is not assigned to two authors belonging to the same institution. This constraint suggests that larger institutions, where collaborations among colleagues may be more frequent, could suffer a size-related bias in their evaluation scores. To validate our claim, we investigate the outcome of artificially splitting Sapienza University of Rome, one of the largest universities in Europe, in a number of separate partitions, according to several criteria, noting significant score increases for several partitioning scenarios.
Content internalism and conceptual engineering
Authors: Pollock Joey 
Published: August 2020

AbstractCappelen (Fixing language, Oxford University Press, Oxford, 2018) proposes a radically externalist framework (the ‘Austerity Framework’) for conceptual engineering. This approach embraces the following two theses. Firstly, the mechanisms that underlie conceptual engineering are inscrutable: they are too complex, unstable and non-systematic for us to grasp. Secondly, the process of conceptual engineering is largely beyond our control. One might think that these two theses are peculiar to the Austerity Framework, or to metasemantic externalism more generally. However, Cappelen argues that there is no reason to think that internalism avoids either commitment. Cappelen argues that to do so she must provide arguments for 3 claims: (a) there are inner states that are scrutable and within our control; (b) concepts supervene on these inner states; and (c) the determination relation from supervenience base to content is itself scrutable and within our control. In this paper, I argue that internalist conceptual role theories of content can meet Cappelen’s challenge.
Trade and environmental pollution in Africa: accounting for consumption and territorial-based emissions
Authors: Adams Samuel , Opoku Eric Evans Osei 
Published: August 2020

AbstractThis paper employs a recently constructed consumption-based carbon dioxide emissions data in which emissions computations are made based on fossil fuel usage domestically, in addition to emissions emanating from imports minus exports. We contrast this measure with the commonly measured territory-based carbon dioxide emissions data and examine how trade performance (split into imports, exports, and total trade) impacts these two measures of carbon dioxide. We focus on 22 sub-Saharan African countries over the period 1995–2014. Employing the system generalized method of moments, we find trade to generally have positive effect on emissions. The results are consistent across the different measures of trade and carbon dioxide emissions. The results of the paper allow us to give some policy suggestions regarding carbon dioxide emissions in sub-Saharan Africa.
Effects of endocrine disruptors on fetal testis development, male puberty, and transition age
Authors: Cargnelutti Francesco , Di Nisio Andrea , Pallotti Francesco , Sabovic Iva , Spaziani Matteo , Tarsitano Maria Grazia , Paoli Donatella , Foresta Carlo 
Published: August 2020

AbstractPurposeEndocrine disruptors (EDs) are exogenous substances able to impair endocrine system; consequently, they may cause numerous adverse effects. Over the last years, particular focus has been given to their harmful effects on reproductive system, but very little is known, especially in males. The aim of this review is to discuss the detrimental effects of EDs exposure on fetal testis development, male puberty, and transition age.MethodsA search for the existing literature focusing on the impact of EDs on fetal testis development, male puberty, andrological parameters (anogenital distance, penile length, and testicular volume), and testicular cancer with particular regard to pubertal age provided the most current information available for this review. Human evidence-based reports were given priority over animal and in vitro experimental results. Given the paucity of available articles on this subject, all resources were given careful consideration.ResultsInformation about the consequences associated with EDs exposure in the current literature is limited and often conflicting, due to the scarcity of human studies and their heterogeneity.ConclusionsWe conclude that current evidence does not clarify the impact of EDs on human male reproductive health, although severe harmful effects had been reported in animals. Despite controversial results, overall conclusion points toward a positive association between exposure to EDs and reproductive system damage. Further long-term studies performed on wide number of subjects are necessary in order to identify damaging compounds and remove them from the environment.
Estimating the Benefits of Derelict Crab Trap Removal in the Gulf of Mexico
Authors: Arthur Courtney , Friedman Scott , Weaver Jennifer , Van Nostrand Dan , Reinhardt James 
Published: August 2020

AbstractGhost fishing in derelict blue crab traps is ubiquitous and causes incidental mortality which can be reduced by trap removal programs. In an effort to scale the benefits of such removal programs, in the context of restoring the Gulf of Mexico after the Deepwater Horizon oil spill, this paper calculates the ecological benefits of trap removal by estimating the extent of derelict blue crab traps across Gulf of Mexico waterbodies and combining these estimates with Gulf-specific crab and finfish mortality rates due to ghost fishing. The highest numbers and densities of traps are found in Louisiana, with estimates ranging up to 203,000 derelict traps across the state and up to 41 traps per square kilometer in areas such as Terrebonne Bay. Mortality rates are estimated at 26 crabs per trap per year and 8 fish per trap per year. The results of this analysis indicate a Gulf-wide removal program targeting 10% of derelict traps over the course of 5 years would lead to a combined benefit of more than 691,000 kg of crabs and fish prevented from mortality in ghost fishing traps. These results emphasize the importance of ongoing derelict trap removal programs. Future work could assess additional benefits of trap removal programs, such as fewer entanglements of marine organisms, improved esthetics, and increases in harvestable catch. Lastly, this model could be utilized by fishery managers to calculate the benefits of other management options designed to decrease the extent and impact of derelict fishing gear.