bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship of cannabis decriminalization in Colorado and cannabis use in individuals with alcohol use disorders
Authors: Hua Jeremy T. , Afshar Majid , Clark Brendan J. , Kovacs Elizabeth J. , Burnham Ellen L. 
Published: March 2020

Abstract
Objective
Over the past decade, cannabis use has become increasingly popular in states that include Colorado. During this time, alcohol use disorders (AUDs) and alcohol-related medical conditions have also been consistently recognized as public health problems with increasing prevalence in the state. Despite the widespread use of cannabis in Colorado, the epidemiology of cannabis use among those with AUDs has been poorly described. Therefore, we sought to examine cannabis use among individuals with likely AUDs and individuals with low-risk alcohol use during a time of major Colorado legislative changes before and after legalization of recreational cannabis in 2012.

Methods
This study was a secondary data analysis conducted with information from 303 participants (80% male) in the Denver, CO metropolitan enrolled between August 2007 and April 2016 for studies related to alcohol and lung health. Of these participants, 188 (62%) were completing inpatient alcohol detoxification with likely AUDs. All participants completed the Alcohol Use Disorder Identification Test (AUDIT) to establish their likelihood of an AUD, and all had information on current cannabis use assessed by questionnaire and urine toxicology testing.

Results
Individuals with likely AUDs more commonly used cannabis compared to control participants (42% vs 27%, p = 0.007). In multiple logistic regression analyses, participant type (likely AUD versus control), tobacco smoking, and age were significantly associated with cannabis smoking; however, the year of participant enrollment was not. Adjusted odds for cannabis use among participants with likely AUDs were 2.97 (1.51–5.82), p = 0.002, while odds for cannabis use among tobacco smokers were 3.67 (1.94–6.93), p < 0.0001. Among control participants, tobacco smoking increased odds of cannabis use seven-fold.

Conclusions
Our findings highlight the exceptionally high odds of cannabis use among individuals with likely AUDs undergoing alcohol detoxification at a Colorado treatment facility before and after legalization of recreational cannabis. Targeted investigations into the medical and psychiatric consequences of combined alcohol and cannabis use are urgently needed to define its health impact in these vulnerable individuals.
Orbit determination and time synchronization for BDS-3 satellites with raw inter-satellite link ranging observations
Authors: Ruan Rengui , Jia Xiaolin , Feng Laiping , Zhu Jun , Huyan Zongbo , Li Jie , Wei Ziqing 
Published: March 2020

AbstractTo provide competitive global positioning and timing services under the condition that monitoring stations are confined to Chinese territory, inter-satellite link (ISL) technology is used by the third-generation BeiDou Navigation Satellite System (BDS-3). The ISL, together with the dual one-way links between satellites and anchor stations, may enable autonomous navigation for BDS-3. In this paper, we propose a general observation model for orbit determination (OD) and time synchronization (TS) directly using non-simultaneous observations, such as raw ISL pseudoranges. With the proposed model, satellite orbits, clocks, and hardware delay biases of ISL equipment can be determined simultaneously by jointly processing inter-satellite one-way pseudorange data and observation data from ground monitoring stations. Moreover, autonomous OD and TS are also achievable with one-way pseudorange data from anchor stations and satellites. Data from eight BDS-3 satellites, two anchor stations, and seven monitoring stations located in China were collected to validate the proposed method. It is shown that by jointly processing data from the ISL and seven monitoring stations, the RMS of overlap orbit differences in radial direction is 0.019 m, the overlap clock difference (95%) is 0.185 ns, and the stability of the estimated hardware delay biases for each satellite is greater than 0.5 ns. Compared with the results obtained with the seven stations, the improvements of orbits in radial direction and clocks are 95.7% and 90.5%, respectively. When the hardware delay biases are fixed to predetermined values, the accuracies of orbits and clocks are further improved. By jointly processing pseudoranges from the satellites and the two anchor stations, the RMS of overlap orbit differences is 0.017 m in the radial direction, and the overlap clock difference (95%) is 0.037 ns. It has also been demonstrated that under the condition of one-way ranging links, the accuracies of orbits and clocks obtained by the above two modes are still significantly better than those obtained by using the data from the monitoring stations alone.
Androgens During Infancy, Childhood, and Adolescence: Physiology and Use in Clinical Practice
Authors: Mason Kelly A , Schoelwer Melissa J , Rogol Alan D 
Published: March 2020

AbstractWe provide an in-depth review of the role of androgens in male maturation and development, from the fetal stage through adolescence into emerging adulthood, and discuss the treatment of disorders of androgen production throughout these time periods. Testosterone, the primary androgen produced by males, has both anabolic and androgenic effects. Androgen exposure induces virilization and anabolic body composition changes during fetal development, influences growth and virilization during infancy, and stimulates development of secondary sexual characteristics, growth acceleration, bone mass accrual, and alterations of body composition during puberty.Disorders of androgen production may be subdivided into hypo- or hypergonadotropic hypogonadism. Hypogonadotropic hypogonadism may be either congenital or acquired (resulting from cranial radiation, trauma, or less common causes). Hypergonadotropic hypogonadism occurs in males with Klinefelter syndrome and may occur in response to pelvic radiation, certain chemotherapeutic agents, and less common causes. These disorders all require testosterone replacement therapy during pubertal maturation and many require lifelong replacement.Androgen (or gonadotropin) therapy is clearly beneficial in those with persistent hypogonadism and self-limited delayed puberty and is now widely used in transgender male adolescents. With more widespread use and newer formulations approved for adults, data from long-term randomized placebo-controlled trials are needed to enable pediatricians to identify the optimal age of initiation, route of administration, and dosing frequency to address the unique needs of their patients.
Planarian cell number depends on blitzschnell, a novel gene family that balances cell proliferation and cell death
Authors: Pascual-Carreras Eudald , Marin-Barba Marta , Herrera-Úbeda Carlos , Font-Martín Daniel , Eckelt Kay , de Sousa Nidia , García-Fernández Jordi , Saló Emili , Adell Teresa 
Published: March 2020

ABSTRACT
Control of cell number is crucial to define body size during animal development and to restrict tumoral transformation. The cell number is determined by the balance between cell proliferation and cell death. Although many genes are known to regulate those processes, the molecular mechanisms underlying the relationship between cell number and body size remain poorly understood. This relationship can be better understood by studying planarians, flatworms that continuously change their body size according to nutrient availability. We identified a novel gene family, blitzschnell (bls), that consists of de novo and taxonomically restricted genes that control cell proliferation:cell death ratio. Their silencing promotes faster regeneration and increases cell number during homeostasis. Importantly, this increase in cell number leads to an increase in body size only in a nutrient-rich environment; in starved planarians, silencing results in a decrease in cell size and cell accumulation that ultimately produces overgrowths. bls expression is downregulated after feeding and is related to activity of the insulin/Akt/mTOR network, suggesting that the bls family evolved in planarians as an additional mechanism for restricting cell number in nutrient-fluctuating environments.
Control of tissue morphogenesis by the HOX gene Ultrabithorax
Authors: Diaz-de-la-Loza Maria-del-Carmen , Loker Ryan , Mann Richard S. , Thompson Barry J. 
Published: March 2020

ABSTRACT
Mutations in the Ultrabithorax (Ubx) gene cause homeotic transformation of the normally two-winged Drosophila into a four-winged mutant fly. Ubx encodes a HOX family transcription factor that specifies segment identity, including transformation of the second set of wings into rudimentary halteres. Ubx is known to control the expression of many genes that regulate tissue growth and patterning, but how it regulates tissue morphogenesis to reshape the wing into a haltere is still unclear. Here, we show that Ubx acts by repressing the expression of two genes in the haltere, Stubble and Notopleural, both of which encode transmembrane proteases that remodel the apical extracellular matrix to promote wing morphogenesis. In addition, Ubx induces expression of the Tissue inhibitor of metalloproteases in the haltere, which prevents the basal extracellular matrix remodelling necessary for wing morphogenesis. Our results provide a long-awaited explanation for how Ubx controls morphogenetic transformation.
“If you please… draw me a cell”. Insights from immune cells
Authors: Moreau Hélène D. , Lennon-Duménil Ana-Maria , Pierobon Paolo 
Published: March 2020

ABSTRACT
Studies in recent years have shed light on the particular features of cytoskeleton dynamics in immune cells, challenging the classical picture drawn from typical adherent cell lines. New mechanisms linking the dynamics of the membrane–cytoskeleton interface to the mechanical properties of immune cells have been uncovered and shown to be essential for immune surveillance functions. In this Essay, we discuss these features, and propose immune cells as a new playground for cell biologists who try to understand how cells adapt to different microenvironments to fulfil their functions efficiently.
Interferon-gamma polymorphisms and risk of iron deficiency and anaemia in Gambian children
Authors: Abuga Kelvin M. , Rockett Kirk A. , Muriuki John Muthii , Koch Oliver , Nairz Manfred , Sirugo Giorgio , Bejon Philip , Kwiatkowski Dominic P. , Prentice Andrew M. , Atkinson Sarah H. 
Published: March 2020

Background: Anaemia is a major public health concern especially in African children living in malaria-endemic regions. Interferon-gamma (IFN-γ) is elevated during malaria infection and is thought to influence erythropoiesis and iron status. Genetic variants in the IFN-γ gene (IFNG) are associated with increased IFN-γ production. We investigated putative functional single nucleotide polymorphisms (SNPs) and haplotypes of IFNG in relation to nutritional iron status and anaemia in Gambian children over a malaria season. Methods: We used previously available data from Gambian family trios to determine informative SNPs and then used the Agena Bioscience MassArray platform to type five SNPs from the IFNG gene in a cohort of 780 Gambian children. We also measured haemoglobin and biomarkers of iron status and inflammation at the start and end of a malaria season. Results: We identified five IFNG haplotype-tagging SNPs (IFNG-1616 [rs2069705], IFNG+874 [rs2430561], IFNG+2200 [rs1861493], IFNG+3234 [rs2069718] and IFNG+5612 [rs2069728]). The IFNG+2200C [rs1861493] allele was associated with reduced haemoglobin concentrations (adjusted β -0.44 [95% CI -0.75, -0.12]; Bonferroni adjusted P = 0.03) and a trend towards iron deficiency compared to wild-type at the end of the malaria season in multivariable models adjusted for potential confounders. A haplotype uniquely identified by IFNG+2200C was similarly associated with reduced haemoglobin levels and trends towards iron deficiency, anaemia and iron deficiency anaemia at the end of the malaria season in models adjusted for age, sex, village, inflammation and malaria parasitaemia. Conclusion: We found limited statistical evidence linking IFNG polymorphisms with a risk of developing iron deficiency and anaemia in Gambian children. More definitive studies are needed to investigate the effects of genetically influenced IFN-γ levels on the risk of iron deficiency and anaemia in children living in malaria-endemic areas.
Walking capacity in boys with Down's syndrome in Saudi Arabia
Authors: Allam Hatem H , Al-Walah Mosfer A , Elsayyad Lamiaa K 
Published: March 2020

Background/Aims Children with Down's syndrome are often considered to be sedentary and less likely to engage in the recommended levels of physical activity. The aim of this study was to compare the walking capacity of male children with Down's syndrome with a group of typically healthy age-matched children in Saudi Arabia. Methods A total of 78 male children aged from 8 to 12 years participated in the study. They were divided into two groups. The first group comprised 37 male children with Down's syndrome, recruited from the Down's Syndrome Charitable Association and Al-Nahda Schools. The second group comprised 41 male children with typical development, who were recruited from regular schools in the same region. Walking capacity was measured with the 6-Minute Walk Test. Results The children with Down's syndrome had significantly reduced 6-Minute Walk Distance scores than children with typical development. Conclusions There is a need to establish good strategies, programmes and early interventions designed to promote physical activity levels and improve the quality of life for people with Down's syndrome.
One-way and near-absolute polarization insensitive near-perfect absorption by using an all-dielectric metasurface
Authors: Yildirim Deniz Umut , Ghobadi Amir , Soydan Mahmut Can , Serebryannikov Andriy E. , Ozbay Ekmel 
Published: March 2020

In this Letter, we numerically propose the one-way perfect absorption of near-infrared radiation in a tunable spectral range with high transmission in the neighboring spectral ranges. This functionality is obtained by using a two-dimensional, guided-mode resonance-based grating-waveguide metasurface that acts as a frequency-selective reflector, a spacer dielectric, and an absorbing oxide layer. Within the bandwidth of the excited guided-mode resonance excited at 1.82 µm (with a full-width at half-maximum of 19 nm), we confirmed perfect absorption when light was incident from one of the two opposite directions, whereas in the other direction, perfect reflection was observed. The forward-to-backward absorption ratio reached as high as 60, while the thickness of the entire structure was on the order of the operating wavelength. In addition to the spectral tunability of the excited resonances and their bandwidths, our proposed device supports transparency windows with 65% transmission in the adjacent frequency bands. Our 2D grating is also verified to enable near-absolute insensitivity to the polarization state of incident light. Geometrical parameter modification also gives our design great tunability, as we also designed a device with a 300 nm absorption/reflection linewidth.
LC-MS/MS analysis of plasma glucosylsphingosine as a biomarker for diagnosis and follow-up monitoring in Gaucher disease in the Spanish population
Authors: Irún Pilar , Cebolla Jorge J. , López de Frutos Laura , De Castro-Orós Isabel , Roca-Espiau Mercedes , Giraldo Pilar 
Published: March 2020

Abstract

Background
Gaucher disease (GD), caused by a deficiency in acid β-glucosidase, leads to the accumulation of glucosylsphingosine (GluSph), which has been used as a powerful biomarker for the diagnosis and follow-up of GD. Our aim was to perform the first retrospective study of GluSph in Spanish patients, analyzing its relationship with classical biomarkers and other parameters of disease and its utility regarding treatment monitoring.

Methods
Classical biomarkers were evaluated retrospectively by standard methods in a total of 145 subjects, including 47 GD patients, carriers, healthy controls and patients suffering from other lysosomal lipidoses. GluSph was also measured using a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method developed as part of the present study.

Results
The optimized method presented intra- and inter-assay variations of 3.1 and 11.5%, respectively, overall recovery higher than 96% and linearity up to plasma concentrations of 1000 ng/mL with 100% specificity and sensitivity. Only GD patients displayed GluSph levels above 5.4 ng/mL at diagnosis and this was significantly correlated with the classical biomarkers chitotriosidase (r = 0.560) and the chemokine CCL18/PARC (CCL18/PARC) (ρ = 0.515), as well as with the Spanish magnetic resonance imaging index (S-MRI, r = 0.364), whereas chitotriosidase correlated with liver volume (r = 0.372) and CCL18/PARC increased in patients with bone manifestations (p = 0.005). GluSph levels decreased with treatment in naïve patients.

Conclusions
Plasma GluSph is the most disease-specific biomarker for GD with demonstrated diagnostic value and responsiveness to therapy. GluSph in the present series of patients failed to demonstrate better correlations with clinical characteristics at onset than classical biomarkers.
On divergence-based author obfuscation: An attack on the state of the art in statistical authorship verification
Authors: Bevendorff Janek , Wenzel Tobias , Potthast Martin , Hagen Matthias , Stein Benno 
Published: March 2020

Abstract
Authorship verification is the task of determining whether two texts were written by the same author based on a writing style analysis. Author obfuscation is the adversarial task of preventing a successful verification by altering a text’s style so that it does not resemble that of its original author anymore. This paper introduces new algorithms for both tasks and reports on a comprehensive evaluation to ascertain the merits of the state of the art in authorship verification to withstand obfuscation.
After introducing a new generalization of the well-known unmasking algorithm for short texts, thus completing our collection of state-of-the-art algorithms for verification, we introduce an approach that (1) models writing style difference as the Jensen-Shannon distance between the character n-gram distributions of texts, and (2) manipulates an author’s writing style in a sophisticated manner using heuristic search. For obfuscation, we explore the huge space of textual variants in order to find a paraphrased version of the to-be-obfuscated text that has a sufficiently high Jensen-Shannon distance at minimal costs in terms of text quality loss. We analyze, quantify, and illustrate the rationale of this approach, define paraphrasing operators, derive text length-invariant thresholds for termination, and develop an effective obfuscation framework. Our authorship obfuscation approach defeats the presented state-of-the-art verification approaches, while keeping text changes at a minimum. As a final contribution, we discuss and experimentally evaluate a reverse obfuscation attack against our obfuscation approach as well as possible remedies.
On applications of bipartite graph associated with algebraic structures
Authors: Zhang Xiujun , Nadeem Muhammed , Ahmad Sarfraz , Siddiqui Muhammad Kamran 
Published: March 2020

Abstract
The latest developments in algebra and graph theory allow us to ask a natural question, what is the application in real world of this graph associated with some mathematical system? Groups can be used to construct new non-associative algebraic structures, loops. Graph theory plays an important role in various fields through edge labeling. In this paper, we shall discuss some applications of bipartite graphs, related with Latin squares of Wilson loops, such as metabolic pathways, chemical reaction networks, routing and wavelength assignment problem, missile guidance, astronomy and x-ray crystallography.
Kourotrophia and “Mothering” Figures: Conceiving and Raising an Infant as a Collective Process in the Greek, Etruscan, and Roman Worlds. Some Religious Evidences in Narratives and Art
Authors: Pedrucci Giulia 
Published: March 2020

AbstractThe paper deals with significantly different sources and historical periods: the parts dedicated to breastfeeding are based on votive statuettes of adults with infant/s from ancient Latium and Southern Etruria; the ones on pregnancy and childbirth are based on two archeological sources – one from Southern Etruria and one from Imperial Rome – which show the male (divine) appropriation of exclusively female biological functions; The parts on mothering are based on the concept of “mothering figures” (male mothering, animal mothering…) through mythological examples from Greek, Etruscan, and Roman art and narratives. Despite the heterogeneous documentation, we may conclude that the mother was not the only active character in the process of conceiving, giving birth, breastfeeding, and raising an infant in the Greek, Etruscan, and Roman societies. Many other figures close to the mother – male and female – were engaged in obtaining divine protection for her and her child; in helping, supporting, and even substituting her when necessary (and, of course, when possible). The research has been conducted mainly by using the concept of kourotrophia and mothering figures as analytical tools.
Die Klimamahnwoche: Information des Gesundheitspersonals über das Thema auf wissenschaftlicher Basis
Authors: Hutter Hans-Peter , Lemmerer Kathrin , Moshammer Hanns , Wallner Peter , Poteser Michael , Medwedeff Thorsten , Weitensfelder Lisbeth 
Published: March 2020

Zusammenfassung
Der Klimawandel stellt eine der größten Herausforderungen unserer Zeit dar. Er hat massive Auswirkungen auf die menschliche Gesundheit. Daher ist das Gesundheitswesen gefordert a) aktiv einen Beitrag zum Klimaschutz zu leisten und b) sich verstärkt auf die Auswirkungen des Klimawandels vorzubereiten. In Österreich wurde die Thematik im Rahmen einer „Klimamahnwoche“ aufgegriffen und es wurden Schritte gesetzt, um auf Ebene des Gesundheitswesens das Bewusstsein zu schärfen.