bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing Wellbore Stability With a Modified Lade Failure Criterion
Authors: Bahrami Babak , Sadatshojaie Ali , Wood David A 
Published: February 2020

Abstract
The importance of evaluating wellbore stability in analyzing and estimating the efficiency of drilling directionally into oil and gas reservoirs is well known. Geomechanical data and failure criterion can be used to model and control rock mass behavior in response to the stresses imposed upon it. Understanding and managing the risks of rock mass deformation significantly improve operational processes such as wellbore stability, sand production, and hydraulic fracturing. The modified Lade failure criterion is established as the most precise failure criterion based on previous studies. By combining it with tensions around the wellbore, a novel relationship is derived for determining the stable mud window. To investigate the accuracy of the new relationship, two geomechanical models (neural network and empirical correlations) for a one-directional wellbore are developed and their performance compared with two other failure criteria (Hoek–Brown and Mogi–Coulomb). The geomechanical parameters (Young’s modulus, Poisson ratio, uniaxial compressive strength, and internal friction coefficient) obtained from the models show that neural network configurations perform better than those built with the empirical equation. The horizontal minimum and maximum stress values across the depth interval of interest (2347–2500 m) are established for a case study reservoir. The model provides an accurate prediction of wellbore instability when applying the modified Lade criterion; the stable mud weight is derived with improved precision compared to the other failure criteria evaluated. A key advantage of the developed method is that it does not require input knowledge of the reservoir’s structural boundaries (e.g., the fault regime) or core test data.
Ethnic variation in the conversion of prediabetes to diabetes among immigrant populations relative to Canadian-born residents: a population-based cohort study
Authors: Fazli Ghazal S , Moineddin Rahim , Bierman Arlene S , Booth Gillian L 
Published: February 2020

ObjectiveThe aim of this study was to compare absolute and relative rates of conversion from prediabetes to diabetes among non-European immigrants to Europeans and Canadian-born residents, overall, and by age and level of glycemia.Research design and methodsWe conducted a retrospective cohort population-based study using administrative health databases from Ontario, Canada, to identify immigrants (n=23 465) and Canadian born (n=1 11 085) aged ≥20 years with prediabetes based on laboratory tests conducted between 2002 and 2011. Individuals were followed until 31 December 2013 for the development of diabetes using a validated algorithm. Immigration data was used to assign ethnicity based on country of origin, mother tongue, and surname. Fine and Gray’s survival models were used to compare diabetes incidence across ethnic groups overall and by age and glucose category.ResultsOver a median follow-up of 5.2 years, 8186 immigrants and 39 722 Canadian-born residents developed diabetes (7.1 vs 6.1 per 100 person-years, respectively). High-risk immigrant populations such as South Asians (HR: 1.72, 95% CI 1.55 to 1.99) and Southeast Asians (HR: 1.65, 95% CI 1.46 to 1.86) had highest risk of converting to diabetes compared with Western Europeans (referent). Among immigrants aged 20–34 years, the adjusted cumulative incidence ranged from 18.4% among Eastern Europeans to 52.3% among Southeast Asians. Conversion rates increased with age in all groups but were consistently high among South Asians, Southeast Asians and Sub-Saharan African/Caribbeans after the age of 35 years. On average, South Asians converted to diabetes 3.1–4.6 years earlier than Western Europeans and at an equivalent rate of conversion to Western Europeans who had a 0.5 mmol/L higher baseline fasting glucose value.ConclusionsHigh-risk ethnic groups converted to diabetes more rapidly, at younger ages, and at lower fasting glucose values than European populations, leading to a shorter window for diabetes prevention.
Risk factors of perioperative mortality from complicated peptic ulcer disease in Africa: systematic review and meta-analysis
Authors: Peiffer Sarah , Pelton Matthew , Keeney Laura , Kwon Eustina G , Ofosu-Okromah Richard , Acharya Yubraj , Chinchilli Vernon M , Soybel David I , Oh John S , Ssentongo Paddy 
Published: February 2020

IntroductionIn 2013, peptic ulcer disease (PUD) caused over 300 000 deaths globally. Low-income and middle-income countries are disproportionately affected. However, there is limited information regarding risk factors of perioperative mortality rates in these countries.ObjectiveTo assess perioperative mortality rates from complicated PUD in Africa and associated risk factors.DesignWe performed a systematic review and a random-effect meta-analysis of literature describing surgical management of complicated PUD in Africa. We used subgroup analysis and meta-regression analyses to investigate sources of variations in the mortality rates and to assess the risk factors contributing to mortality.ResultsFrom 95 published reports, 10 037 patients underwent surgery for complicated PUD. The majority of the ulcers (78%) were duodenal, followed by gastric (14%). Forty-one per cent of operations were for perforation, 22% for obstruction and 9% for bleeding. The operations consisted of vagotomy (38%), primary repair (34%), resection and reconstruction (12%), and drainage procedures (6%). The overall PUD mortality rate was 6.6% (95% CI 5.4% to 8.1%). It increased to 9.7% (95% CI 7.1 to 13.0) when we limited the analysis to studies published after the year 2000. The correlation was higher between perforated PUD and mortality rates (r=0.41, p<0.0001) than for bleeding PUD and mortality rates (r=0.32, p=0.001). Non-significant differences in mortality rates existed between sub-Saharan Africa (SSA) and North Africa and within SSA.ConclusionPerioperative mortality rates from complicated PUD in Africa are substantially high and could be increasing over time, and there are possible regional differences.
Clinical indicators to identify neuropathic pain in low back-related leg pain: protocol for a modified Delphi study
Authors: Mistry Jai , Falla Deborah , Noblet Tim , Heneghan Nicola R , Rushton Alison B 
Published: February 2020

IntroductionNeuropathic low back-related leg pain (LBLP) can be a challenge to healthcare providers to diagnose and treat. Accurate diagnosis of neuropathic pain is fundamental to ensure appropriate intervention is given. However, to date there is no gold standard to diagnose neuropathic LBLP. A Delphi study will therefore be conducted to obtain an expert-derived consensus list of clinical indicators to identify a neuropathic component to LBLP.Methods/analysisIncluded participants will be considered experts within the field as measured against a predefined eligibility criterion. Through an iterative multistage process, participants will rate their agreement with a list of clinical indicators and suggest any missing clinical indicators during each round. Agreement will be measured using a 5-point Likert scale. Descriptive statistics will be used to measure agreement; median, IQR and percentage of agreement. A priori consensus criteria will be defined for each round. Data analysis at the end of round three will enable a list of clinical indicators to be derived.Ethics and disseminationEthical approval was gained from the University of Birmingham (ERN_19-1142). On completion of the study, findings will be disseminated in a peer-reviewed journal and presented at relevant conferences.
Development of a casemix classification to predict costs of home care in the Netherlands: a study protocol
Authors: Elissen Arianne Mathilda Josephus , Verhoeven Gertjan Sebastiaan , de Korte Maud Hortense , van den Bulck Anne Odilia Emile , Metzelthin Silke Friederike , van der Weij Lieuwe Christiaan , Stam Jaap , Ruwaard Dirk , Mikkers Misja Chiljon 
Published: February 2020

IntroductionCompared with fee-for-service systems, prospective payment based on casemix classification is thought to promote more efficient, needs-based care provision. We aim to develop a casemix classification to predict the costs of home care in the Netherlands.Methods and analysisThe research is designed as a multicentre, cross-sectional cohort study using quantitative methods to identify the relative cost predictors of home care and combine these into a casemix classification, based on individual episodes of care. The dependent variable in the analyses is the cost of home care utilisation, which is operationalised through various measures of formal and informal care, weighted by the relative wage rates of staff categories. As independent variables, we will use data from a recently developed Casemix Short-Form questionnaire, combined with client information from participating home care providers’ (nursing) classification systems and data on demographics and care category (ie, a classification mandated by health insurers). Cost predictors are identified using random forest variable importance measures, and then used to build regression tree models. The casemix classification will consist of the leaves of the (pruned) regression tree. Internal validation is addressed by using cross-validation at various stages of the modelling pathways. The Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis statement was used to prepare this study protocol.Ethics and disseminationThe study was classified by an accredited Medical Research Ethics Committee as not subject to the Dutch Medical Research Involving Human Subjects Act. Findings are expected in 2020 and will serve as input for the development of a new payment system for home care in the Netherlands, to be implemented at the discretion of the Dutch Ministry of Health, Welfare and Sports. The results will also be published in peer-reviewed publications and policy briefs, and presented at (inter)national conferences.
Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries
Authors: Ghosh Tarini Shankar , Rampelli Simone , Jeffery Ian B , Santoro Aurelia , Neto Marta , Capri Miriam , Giampieri Enrico , Jennings Amy , Candela Marco , Turroni Silvia , Zoetendal Erwin G , Hermes Gerben D A , Elodie Caumon , Meunier Nathalie , Brugere Corinne Malpuech , Pujos-Guillot Estelle , Berendsen Agnes M , De Groot Lisette C P G M , Feskins Edith J M , Kaluza Joanna , Pietruszka Barbara , Bielak Marta Jeruszka , Comte Blandine , Maijo-Ferre Monica , Nicoletti Claudio , De Vos Willem M , Fairweather-Tait Susan , Cassidy Aedin , Brigidi Patrizia , Franceschi Claudio , O'Toole Paul W 
Published: February 2020

ObjectiveAgeing is accompanied by deterioration of multiple bodily functions and inflammation, which collectively contribute to frailty. We and others have shown that frailty co-varies with alterations in the gut microbiota in a manner accelerated by consumption of a restricted diversity diet. The Mediterranean diet (MedDiet) is associated with health. In the NU-AGE project, we investigated if a 1-year MedDiet intervention could alter the gut microbiota and reduce frailty.DesignWe profiled the gut microbiota in 612 non-frail or pre-frail subjects across five European countries (UK, France, Netherlands, Italy and Poland) before and after the administration of a 12-month long MedDiet intervention tailored to elderly subjects (NU-AGE diet).ResultsAdherence to the diet was associated with specific microbiome alterations. Taxa enriched by adherence to the diet were positively associated with several markers of lower frailty and improved cognitive function, and negatively associated with inflammatory markers including C-reactive protein and interleukin-17. Analysis of the inferred microbial metabolite profiles indicated that the diet-modulated microbiome change was associated with an increase in short/branch chained fatty acid production and lower production of secondary bile acids, p-cresols, ethanol and carbon dioxide. Microbiome ecosystem network analysis showed that the bacterial taxa that responded positively to the MedDiet intervention occupy keystone interaction positions, whereas frailty-associated taxa are peripheral in the networks.ConclusionCollectively, our findings support the feasibility of improving the habitual diet to modulate the gut microbiota which in turn has the potential to promote healthier ageing.
A sterile neutrino search at compact materials irradiation facility
Authors: Chen Liangwen , Cai Han-Jie , Ciuffoli Emilio , Evslin Jarah , Fu Fen , Zhang Sheng , Chen Xurong , Yang Lei , Zhan Wenlong 
Published: February 2020

AbstractThe compact material irradiation facility (CMIF) is a current project in China that will provide a compact deuteron-beryllium neutron source. The target of this facility will be an intense and compact Isotope Decay-At-Rest (IsoDAR) neutrino source. In this paper, we propose to test the sterile neutrino hypothesis using CMIF as the neutrino source. At CMIF platform, the electron antineutrino production rate can be up to$$2.0\times 10^{19}$$2.0×1019per day. When paired with an 80 t liquid scintillator detector to study short baseline electron antineutrino disappearance, the inverse beta decay (IBD) event rate is large enough to investigate the parameter ranges of interest for neutrino anomalies. Our sensitivity analysis shows that a short baseline experiment at this platform will provide a very competitive sterile neutrino search, especially in the high-$$\Delta m^2$$Δm2region ($$\Delta m^2 >10\,\text {eV}^2$$Δm2>10eV2).
The role of transverse momentum on the nuclear valence and sea quark distribution functions
Authors: Nematollahi H. 
Published: February 2020

AbstractWe investigate the transverse momentum dependence of valence and sea quark distribution functions of light asymmetric nuclei ($$^{3}He$$3He and $$^{7}Li$$7Li). To this end, we first calculate the valence and sea distributions of these nuclei applying a parametrization method in which the parton distribution functions (PDFs) of nucleus are related to those of free nucleon via a weight function that contains the nuclear modifications. Then we obtain the unpolarized transverse momentum dependent (TMD) PDFs of the nucleus using the covariant parton model (CPM) approach. We also compute the valence and sea quark distributions ratios of $$^{3}He$$3He and $$^{7}Li$$7Li to those of deuteron and present the results with respect to x (Bjorken variable) at fixed values of transverse momentum. It is found that these ratios shift to the larger values of x by increasing the transverse momentum value as expected and they are not transverse momentum dependent in large x region.
Responses of gut and pancreatic hormones, bile acids, and fibroblast growth factor-21 differ to glucose, protein, and fat ingestion after gastric bypass surgery
Authors: Jensen Christian Zinck , Bojsen-Møller Kirstine N. , Svane Maria S. , Holst Line M. , Hermansen Kjeld , Hartmann Bolette , Wewer Albrechtsen Nicolai Jacob , Kuhre Rune Ehrenreich , Kristiansen Viggo B. , Rehfeld Jens Frederik , Clausen Trine R. , Holst Jens J. , Madsbad Sten 
Published: February 2020

Postprandial gut hormone responses change after Roux-en-Y gastric bypass (RYGB), and we investigated the impact of glucose, protein, and fat (with and without pancreas lipase inhibition) on plasma responses of gut and pancreas hormones, bile acids, and fibroblast growth factor 21 (FGF-21) after RYGB and in nonoperated control subjects. In a randomized, crossover study 10 RYGB operated and 8 healthy weight-matched control subjects were administered 4 different 4-h isocaloric (200 kcal) liquid meal tests containing >90 energy (E)% of either glucose, protein (whey protein), or fat (butter with and without orlistat). The primary outcome was glucagon-like peptide-1 (GLP-1) secretion (area under the curve above baseline). Secondary outcomes included responses of peptide YY (PYY), glucose-dependent insulinotropic polypeptide (GIP), cholecystokinin (CCK), glicentin, neurotensin, ghrelin, insulin, glucagon, bile acids, and FGF-21. In the RYGB group the responses of GLP-1, GIP, glicentin, FGF-21, and C-peptide were increased after glucose compared with the other meals. The neurotensin and bile acids responses were greater after fat, while the glucagon and CCK responses were greater after protein ingestion. Furthermore, compared with control subjects, RYGB subjects had greater responses of total PYY after glucose, glucagon after glucose and fat, glicentin after glucose and protein, and GLP-1 and neurotensin after all meals, while GIP and CCK responses were lower after fat. Ghrelin responses did not differ between meals or between groups. Orlistat reduced all hormone responses to fat ingestion, except for ghrelin in the RYGB group. In conclusion, after RYGB glucose is a more potent stimulator of most gut hormones, especially for the marked increased secretion of GLP-1 compared with fat and protein. NEW & NOTEWORTHY We investigated the impact of glucose, protein, and fat meals on intestinal and pancreatic hormones, bile acid, and fibroblast growth factor 21 (FGF-21) secretion in gastric bypass-operated patients compared with matched nonoperated individuals. The fat meal was administered with and without a pancreas lipase inhibitor. We found that the impact of the different meals on gut hormones, bile, and FGF 21 secretion differ and was different from the responses observed in nonoperated control subjects.
Organ-specific lymphatics play distinct roles in regulating HDL trafficking and composition
Authors: Gracia Gracia , Cao Enyuan , Johnston Angus P. R. , Porter Christopher J. H. , Trevaskis Natalie L. 
Published: February 2020

Recently, peripheral lymphatic vessels were found to transport high-density lipoprotein (HDL) from interstitial tissues to the blood circulation during reverse cholesterol transport. This function is thought to be critical to the clearance of cholesterol from atherosclerotic plaques. The role of organ-specific lymphatics in modulating HDL transport and composition is, however, incompletely understood. This study aimed to 1) determine the contribution of the lymphatics draining the intestine and liver (which are major sites of HDL synthesis) to total (thoracic) lymph HDL transport and 2) verify whether the HDLs in lymph are derived from specific organs and are modified during trafficking in lymph. The mesenteric, hepatic, or thoracic lymph duct was cannulated in nonfasted Sprague-Dawley rats, and lymph was collected over 5 h under anesthesia. Whole lymph and specific lymph lipoproteins (isolated by ultracentrifugation) were analyzed for protein and lipid composition. The majority of thoracic lymph fluid, protein, and lipid mass was sourced from the mesenteric, and to a lesser extent, hepatic lymph. Mesenteric and thoracic lymph were both rich in chylomicrons and very low-density lipoprotein, whereas hepatic lymph and plasma were HDL-rich. The protein and lipid mass in thoracic lymph HDL was mostly sourced from mesenteric lymph, whereas the cholesterol mass was equally sourced from mesenteric and hepatic lymph. HDLs were compositionally distinct across the lymph sources and plasma. The composition of HDL also appeared to be modified during passage from the mesenteric and hepatic to the thoracic lymph duct. Overall, this study demonstrates that the lipoproteins in lymph are organ specific in composition, and the intestine and liver appear to be the main source of HDL in the lymph.NEW & NOTEWORTHY High-density lipoprotein in lymph are organ-specific in composition and derive mostly from the intestine and liver. High-density lipoprotein also appears to be remodeled during transport through the lymphatics. These findings have implications to cardiometabolic diseases that involve perturbations in lipoprotein distribution and metabolism.
Results of a Randomized Phase IIb Trial of Nelipepimut-S + Trastuzumab versus Trastuzumab to Prevent Recurrences in Patients with High-Risk HER2 Low-Expressing Breast Cancer
Authors: Clifton G. Travis , Hale Diane , Vreeland Timothy J. , Hickerson Annelies T. , Litton Jennifer K. , Alatrash Gheath , Murthy Rashmi K. , Qiao Na , Philips Anne V. , Lukas Jason J. , Holmes Jarrod P. , Peoples George E. , Mittendorf Elizabeth A. 
Published: February 2020

Abstract

Purpose:
Preclinical data provide evidence for synergism between HER2-targeted peptide vaccines and trastuzumab. The efficacy of this combination was evaluated in patients with HER2 low-expressing breast cancer in the adjuvant setting.

Patients and Methods:
A phase IIb, multicenter, randomized, single-blinded, controlled trial enrolled disease-free patients after standard therapy completion (NCT01570036). Eligible patients were HLA-A2, A3, A24, and/or A26+, and had HER2 IHC 1+/2+, FISH nonamplified breast cancer, that was node positive and/or hormone receptor–negative [triple-negative breast cancer (TNBC)]. Patients received trastuzumab for 1 year and were randomized to placebo (GM-CSF, control) or nelipepimut-S (NPS) with GM-CSF. Primary outcome was 24-month disease-free survival (DFS). Secondary outcomes were 36-month DFS, safety, and immunologic response.

Results:
Overall, 275 patients were randomized; 136 received NPS with GM-CSF, and 139 received placebo with GM-CSF. There were no clinicopathologic differences between groups. Concurrent trastuzumab and NPS with GM-CSF was safe with no additional overall or cardiac toxicity compared with control. At median follow-up of 25.7 (interquartile range, 18.4–32.7) months, estimated DFS did not significantly differ between NPS and control [HR, 0.62; 95% confidence interval (CI), 0.31–1.25; P = 0.18]. In a planned exploratory analysis of patients with TNBC, DFS was improved for NPS versus control (HR, 0.26; 95% CI, 0.08–0.81, P = 0.01).

Conclusions:
The combination of NPS with trastuzumab is safe. In HER2 low-expressing breast cancer, no significant difference in DFS was seen in the intention-to-treat analysis; however, significant clinical benefit was seen in patients with TNBC. These findings warrant further investigation in a phase III randomized trial.