bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor burden and location as prognostic factors in patients treated by iodine seed implant brachytherapy for localized prostate cancers
Authors: Meynard Claire , Huertas Andres , Dariane Charles , Toublanc Sandra , Dubourg Quentin , Urien Saik , Timsit Marc-Olivier , Méjean Arnaud , Thiounn Nicolas , Giraud Philippe 
Published: December 2019

Abstract
Background
Iodine seed implant brachytherapy is indicated for low risk and selected favorable intermediate risk prostate cancers. A percentage of positive biopsies > 50% is usually considered as a contra-indication, and the tumor location could also influence the treatment efficacy. We studied the association of the percentage of positive biopsy cores, and tumor location, with progression-free survival.

Methods
Among the 382 patients treated at our center by permanent implant iodine seed brachytherapy for a localized prostate cancer between 2006 and 2013, 282 had accessible detailed pathology reports, a minimum follow-up of 6 months, and were included. Progression was defined as a biochemical, local, nodal, or distant metastatic relapse. We studied cancer location on biopsies (base, midgland or apex of the prostate) and percentage of positive biopsy cores, as well as potential confounders (pre-treatment PSA, tumor stage, Gleason score, risk group according to D’Amico’s classification modified by Zumsteg, adjunction of androgen deprivation therapy, and dosimetric data).

Results
Most patients (197; 69.9%) had a low risk, 67 (23.8%) a favorable intermediate risk, 16 (5.7%) an unfavorable intermediate risk, and 1 (0.3%) a high-risk prostate cancer. An involvement of the apex was found for 131 patients (46,5%), of the midgland for 149 (52,8%), and of the base for 145 (51,4%). The median percentage of positive biopsy cores was 17% [3–75%]. The median follow-up was 64 months [12–140]. Twenty patients (7%) progressed: 4 progressions (20%) were biochemical only, 7 (35%) were prostatic or seminal, 6 (30%) were nodal, and 3 (15%) were metastatic. The median time to failure was 39.5 months [9–108]. There were more Gleason scores ≥7 among patients who progressed (40% vs 19%; p = 0.042). None of the studied covariates (including tumor location, and percentage of positive biopsy cores), were significantly associated with progression-free survival. The risk group showed a trend towards an association (p = 0.055).

Conclusions
Brachytherapy is an efficient treatment (5-year control rate of 93%) for patients carefully selected with classical criteria. The percentage and location of positive biopsies were not significantly associated with progression-free survival. A Gleason score ≥ 7 was more frequent in case of progression.
Therapeutic effect of whole brain radiotherapy on advanced NSCLC between EGFR TKI-naïve and TKI-resistant
Authors: Zhao Lihao , Cai Xiaona , Chen Didi , Ye Xuxue , Gao Mengdan , Lu Lihuai , Su Huafang , Su Meng , Hou Meng , Xie Congying 
Published: December 2019

Abstract
Background
The development of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) has dramatically improved the prognosis of patients with EGFR-mutant non-small-cell lung cancer (NSCLC). The purpose of this study is to investigate the clinical outcome with or without EGFR-TKI resistance before WBRT and the sequence between EGFT-TKIs and whole brain radiotherapy (WBRT) of EGFR-mutant NSCLC patients who developed multiple brain metastases (BMs).

Patients and methods
Three hundred forty-four EGFR-mutant NSCLC patients with multiple BMs were reviewed. Enrolled patients were divided into TKI-naïve group and TKI-resistant group. The intracranial progression-free survival (PFS) and overall survival (OS) were analyzed via the Kaplan-Meier method.

Results
For patients with multiple BMs treated by WBRT, the median intracranial PFS and OS were longer in the TKI-naïve group than those in the TKI-resistant group, but there were no statistically significant between two groups (Intracranial PFS: 7.7 vs. 5.4 months, p = 0.052; OS: 11.2 vs. 9.2 months, p = 0.106). For patients with Lung-molGPA 0–2, no significant differences in median intracranial PFS (6.2 vs. 5.2 months, p = 0.123) and OS (7.8 vs. 6.7 months, p = 0.514) between TKI-naïve and TKI-resistant groups. For patients with Lung-molGPA 2.5–4, intracranial PFS: 12.8 vs. 10.1 months; OS: 23.3 vs. 15.3 months.

Conclusions
Our study found that there were no difference in intracranial PFS and OS in all patients between the two groups of TKI-naïve and TKI-resistant. But for patients in subgroup of Lung-molGPA 2.5–4, there were a better intracranial PFS and OS in TKI-naïve group.
From civilian service to military service: what led policy-makers to remove nursing care from field units of the Israeli defense force (IDF) and return it later?
Authors: Segev Ronen 
Published: December 2019

AbstractBackgroundFrom the very onset, Israeli military nurses served in supporting positions on the front lines, shoulder to shoulder with men. When the IDF was established in 1948, nurses were sent to serve near areas of conflict and were not included in compulsory military service in field units. Once the military hospitals were closed in 1949, nursing in the Medical Corps lost a clear military purpose, and its main contribution was in the civilian arena. From 1949 until 2000, most recruited military nurses operated their mandatory service mainly in a civilian framework according to the integration agreement between the ministry of defense to the ministry of health. Between 2000 to 2018, military nurses served at home front military clinics and in headquarters jobs at the Medicine Corps. In2018, the Medical Corps decided to integrate military nurses into the Israeli military service in order to cope with the shortage of military physicians, among other things, and ensure appropriate availability of medical and health services for military units.. This study examines, for the first time, the considerations that led to the closure of military hospitals and the transfer of the military service of nurses in the IDF to the Ministry of Health in 1949 and the decision in 2018 to return the military nurses to the field’s military battalions.MethodsThe study was based on an analysis of documents from the IDF archives, the Israeli parliament archive, the David Ben-Gurion archive, articles from periodical newspapers, and interviews with nurses and partners in the Israeli Medical Corps.ResultsDuring almost 70 years, Israeli military nursing’s main contribution was to the civilian hospitals. The return of nursing care to the IDF field units in recent years intended to supplement the medicine corps demands in field units by placing qualified academic nurses.ConclusionsThe removal of nursing care from the IDF field units was provided as a response to the needs of the health demands of the emerging state. Until 2018 there was no significant need for military nurses except in emergency time. This is in contrast to other military nursing units.
Infrared stripe correction algorithm based on wavelet decomposition and total variation-guided filtering
Authors: Wang Ende , Jiang Ping , Li Xuepeng , Cao Hui 
Published: December 2019

AbstractStripe non-uniformity severely affects the quality of infrared images. It is challenging to remove stripe noise in low-texture images without blurring the details. We propose a single-frame image stripe correction algorithm that removes infrared noise while preserving image details. Firstly, wavelet transform is used for multi-scale analysis of the image. At the same time, Total variation model is used for small window to smooth the original image. The small-scale total variation model can well preserve the edge information of the image, but it will leave stripe noise. Therefore, according to the prior knowledge of the vertical component of the stripe noise, the spatial filtering is finally performed: the smoothed image is used as the guide image for the stripe noise denoising. It is possible to prevent the lead filter from mistaking the strong stripe noise as edge detail, resulting in corrected image residual streak noise. The algorithm is systematically evaluated by experiments on simulated images and original infrared images, as well as compared with the current advanced infrared stripe non-uniformity correction algorithms. It is proved that our algorithm can better eliminate stripe noise and preserve edge details.
Purification and characterization of fat body lipase from the greater wax moth, Galleria mellonella (Lepidoptera: Pyralidae)
Authors: Mahdy Rahma R. Z. , Mo’men Shaimaa A. , Abd El-Bar Marah M. , Barakat Emad M. S. 
Published: December 2019

AbstractBackgroundInsect lipid mobilization and transport are currently under research, especially lipases and lipophorin because of their roles in the production of energy and lipid transport at a flying activity. The present study has been conducted to purify intracellular fat body lipase for the first time, from the last larval instar ofGalleria mellonella.ResultsPurification methods by combination of ammonium sulfate [(NH4)2SO4] precipitation and gel filtration using Sephadex G-100 demonstrated that the amount of protein and the specific activity of fat body lipase were 0.008633 ± 0.000551 mg/ml and 1.5754 ± 0.1042 μmol/min/mg protein, respectively, with a 98.9 fold purity and recovery of 50.81%. Hence, the sephadex G-100 step was more effective in the purification process. SDS-PAGE and zymogram revealed that fat body lipase showed two monomers with molecular weights of 178.8 and 62.6 kDa. Furthermore, biochemical characterization of fat body lipase was carried out through testing its activities against several factors, such as different temperatures, pH ranges, metal ions, and inhibitors ending by determination of their kinetic parameters with the use of p-nitrophenyl butyrate (PNPB) as a substrate. The highest activities of enzyme were determined at the temperature ranges of 35–37 °C and 37–40 °C and pH ranges of 7–9 and 7–10. The partially purified enzyme showed significant stimulation by Ca2+, K+, and Na+metal ions indicating that fat body lipase is metalloproteinase. Lipase activity was strongly inhibited by some inhibitors; phenylmethylsulfonyl fluoride (PMSF), ethylene-diaminetetractic acid (EDTA), and ethylene glycoltetraacetic acid (EGTA) providing evidence of the presence of serine residue and activation of enzymes by metal ions. Kinetic parameters were 0.316 Umg− 1Vmaxand 301.95 mM Km.ConclusionConsidering the purification of fat body lipase from larvae and the usage of some inhibitors especially ion chelating agents, it is suggested to develop a successful control ofGalleria mellonellain near future by using lipase inhibitors.
Biomechanical function of the anterolateral ligament of the knee: a systematic review
Authors: Lee Jin Kyu , Seo Young Jin , Jeong Soo-Young , Yang Jae-Hyuk 
Published: December 2019

Abstract
Background
It has been suggested that the anterolateral ligament (ALL) is an important anterolateral stabilizer of the knee joint which functions to prevent anterolateral subluxation and anterior subluxation at certain flexion angles in the knee.

Purpose
To analyze and systematically interpret the biomechanical function of the ALL.

Methods
An online search was conducted for human cadaveric biomechanical studies that tested function of the ALL in resisting anterolateral subluxation and anterior subluxation of the knee. Two reviewers independently searched Medline, Embase, and the Cochrane Database of Systematic Reviews for studies up to 25 September 2018. Biomechanical studies not reporting the magnitude of anterior tibial translation or tibial internal rotation in relation to the function of the ALL were excluded.

Results
Twelve biomechanical studies using human cadavers evaluating parameters including anterior tibial translation and/or internal tibial rotation in anterior cruciate ligament (ACL)-sectioned and ALL-sectioned knees were included in the review. Five studies reported a minor increase or no significant increase in anterior tibial translation and internal tibial rotation with further sectioning of the ALL in ACL-deficient knees. Five studies reported a significant increase in knee laxity in tibial internal rotation or pivot shift with addition of sectioning the ALL in ACL-deficient knees. Two studies reported a significant increase in both anterior tibial translation and internal tibial rotation during application of the anterior-drawer and pivot-shift tests after ALL sectioning.

Conclusion
There was inconsistency in the biomechanical characteristics of the ALL of the knee in resisting anterolateral and anterior subluxation of the tibia.
Return to Sport Tests’ Prognostic Value for Reinjury Risk after Anterior Cruciate Ligament Reconstruction: A Systematic Review
Authors: ASHIGBI EVANS YAYRA KWAKU , BANZER WINFRIED , NIEDERER DANIEL 
Published: December 2019

ABSTRACT

Introduction
Return to sports (RTS) clearance after anterior cruciate ligament (ACL) reconstruction typically includes multiple assessments. The ability of these tests to assess the risk of a reinjury remains unknown.

Purpose
To assess and rate RTS self-reported function and functional tests on prognostic value for reinjury risk after ACL reconstruction and RTS. Study Design: Systematic review on level 2 studies.

Methods
PubMed, Web of Knowledge, Cochrane Library, and Google Scholar databases were searched for articles published before March 2018. Original articles in English or German that examined reinjury risks/rates after primary (index) ACL injury, ACL reconstruction, and RTS were included. All RTS functional tests used in the included studies were analyzed by retrieving an effect size with predictive value (odds ratio, relative risk (risk ratio), positive predictive value, positive likelihood ratio, or hazard rate).

Results
A total of 276 potential studies were found; eight studies (moderate to high quality) on 6140 patients were included in the final analysis. The reinjury incidence recorded in the included studies ranged from 1.5% to 37.5%. Four studies reported a combination of isokinetic quadriceps strength at different velocities and a number of hop tests as predictive with various effect sizes. One reported isokinetic hamstring to quadriceps ratio (hazard rate = 10.6) as predictive. Two studies reported functional questionnaires (knee injury and osteoarthritis outcome score and Tampa Scale of Kinesiophobia-11; RR = 3.7–13) and one study showed that kinetic and kinematic measures during drop vertical jumps were predictive (odds ratio, 2.3–8.4) for reinjury and/or future revision surgery.

Conclusions
Based on level 2 evidence, passing a combination of functional tests with predetermined cutoff points used as RTS criteria is associated with reduced reinjury rates. A combination of isokinetic strength and hop tests is recommended during RTS testing.
Predictors of the Acute Postprandial Response to Breaking Up Prolonged Sitting
Authors: HENSON JOSEPH , EDWARDSON CHARLOTTE L. , CELIS-MORALES CARLOS A. , DAVIES MELANIE J. , DUNSTAN DAVID W. , ESLIGER DALE W. , GILL JASON M. R. , KAZI AADIL , KHUNTI KAMLESH , KING JAMES , MCCARTHY MATTHEW , SATTAR NAVEED , STENSEL DAVID J. , VELAYUDHAN LATHA , ZACCARDI FRANCESCO , YATES THOMAS 
Published: December 2019

ABSTRACT

Purpose
To identify predictors of favorable changes to postprandial insulin and glucose levels in response to interrupting prolonged sitting time with standing or light-intensity physical activity.

Methods
Data were combined from four similarly designed randomized acute cross-over trials (n = 129; body mass index [BMI] range, 19.6–44.6 kg·m−2; South Asian = 31.0%; dysglycemia = 27.1%). Treatments included: prolonged sitting (6.5 h) or prolonged sitting broken-up with either standing or light-intensity physical activity (5 min every 30 min). Time-averaged postprandial responses for insulin and glucose were calculated for each treatment (mean ± 95% confidence interval). Mutually adjusted interaction terms were used to examine whether anthropometric (BMI), demographic (age, sex, ethnicity [white European vs South Asian]) and a cardiometabolic variable (Homeostatic Model Assessment of Insulin Resistance)-modified responses.

Results
Postprandial insulin and glucose were reduced when individuals interrupted prolonged sitting with bouts of light physical activity, but not with standing. Reductions in time-averaged postprandial insulin were more pronounced if individuals were South Asian compared with white European (−18.9 mU·L−1 [−23.5%] vs −8.2 mU·L−1 [−9.3%]), female compared with male (−15.0 mU·L−1 [−21.2%] vs −12.1 mU·L−1 [−17.6%]) or had a BMI ≥27.2 kg·m−2 (−20.9 mU·L−1 [−22.9%] vs −8.7 mU·L−1 [−18.2%]). Similarly, being female (−0.4 mmol·L−1 [−0.6 mmol·L−1, −0.2 mmol·L−1], −6.8% vs –0.1 mmol·L−1 [−0.3 mmol·L−1, 1 mmol·L−1], −1.7%) or having a BMI ≥27.2 kg·m−2 (−0.4 mmol·L−1 [−0.6 mmol·L−1, −0.2 mmol·L−1], −6.7% vs –0.2 mmol·L−1 [−0.4 mmol·L−1, 0.0 mmol·L−1], −3.4%) modified the postprandial glucose response. No significant interactions were found for Homeostatic Model Assessment of Insulin Resistance or age.

Conclusions
Being female, South Asian, or having a higher BMI, all predicted greater reductions in postprandial insulin, whereas being female and having a higher BMI predicted greater reductions in postprandial glucose when sitting was interrupted with light physical activity. These results could help to guide personalized interventions in high-risk participants for whom breaking prolonged sitting time with light activity may yield the greatest therapeutic potential.
Relationship of Knee Forces to Subjective Function Pre- and Post-ACL Reconstruction
Authors: SMALE KENNETH B. , CONCONI MICHELE , SANCISI NICOLA , ALKJAER TINE , KROGSGAARD MICHAEL R. , PARENTI-CASTELLI VINCENZO , BENOIT DANIEL L. 
Published: December 2019

ABSTRACT

Purpose
Although basic objective measures (e.g., knee laxity, strength, and hop tests) have been related to subjective measures of function, associations between knee-specific objective and subjective measures have yet to be completed. The objective was to determine if knee joint contact and ligament forces differ between pre– and post–anterior cruciate ligament (ACL) reconstructed states and if these forces relate to their patient’s respective subjective functional ability scores.

Methods
Twelve patients performed a hopping task before and after reconstruction. Magnetic resonance images and OpenSim were used to develop patient-specific models in static optimization and joint reaction analyses. Questionnaires concerning each patient’s subjective functional ability were also collected and correlated with knee joint contact and ligament forces.

Results
No significant differences were observed between deficient and reconstructed groups with respect to knee joint contact or ligament forces. Nevertheless, there were several significant (P < 0.05) moderate to strong correlations between subjective and objective measures including Tegner activity level to contact force in both states (r = 0.67–0.76) and International Knee Documentation Committee to compressive and anterior shear forces (r = 0.64–0.66).

Conclusion
Knee-specific objective measures of a patient’s functional capacity can represent their subjective ability, which explains this relationship to a greater extent than past anatomical and gross objective measures of function. This consolidation is imperative for improving the current rehabilitation schema as it allows for external validation of objective and subjective functional measures. With poor validation of subjective function against objective measures of function, the reinjury rate is unlikely to diminish, continuing the heavy financial burden on health care systems.
The fate of Baker’s cysts at mid-term follow-up after total knee arthroplasty
Authors: Hommel Hagen , Becker Roland , Fennema Peter , Kopf Sebastian 
Published: December 2019

Aims We report the natural course of Baker’s cysts following total knee arthroplasty (TKA) at short- and mid-term follow-up. Methods In this prospective case series, 105 TKA patients were included. All patients who received surgery had a diagnosis of primary osteoarthritis and had preoperatively presented with a Baker’s cyst. Sonography and MRI were performed to evaluate the existence and the gross size of the cyst before TKA, and sonography was repeated at a mean follow-up time of 1.0 years (0.8 to 1.3; short-term) and 4.9 years (4.0 to 5.6; mid-term) after TKA. Symptoms potentially attributable to the Baker’s cyst were recorded at each assessment. Results At the one-year follow-up analysis, 102 patients were available. Of those, 91 patients were available for the 4.9-year assessment (with an 86.7% follow-up rate (91/105)). At the short- and mid-term follow-up, a Baker’s cyst was still present in 87 (85.3%) and 30 (33.0%) patients, respectively. Of those patients who retained a Baker’s cyst at the short-term follow-up, 31 patients (35.6%) had popliteal symptoms. Of those patients who continued to have a Baker’s cyst at the mid-term follow-up, 17 patients (56.7%) were still symptomatic. The mean preoperative cyst size was 14.5 cm2 (13.1 to 15.8). At the short- and mid-term follow-up, the mean cyst size was 9.7 cm2 (8.3 to 11.0) and 10.4 cm2 (9.8 to 11.4), respectively. A significant association was found between the size of the cyst at peroperatively and the probability of resolution, with lesions smaller than the median having an 83.7% (36/43) probability of resolution, and larger lesions having a 52.1% (25/48) probability of resolution (p < 0.001). At the mid-term follow-up, no association between cyst size and popliteal symptoms was found. Conclusion At a mean follow-up of 4.9 years (4.0 to 5.6) after TKA, the majority (67.0%, 61/91) of the Baker’s cysts that were present preoperatively had disappeared. The probability of cyst resolution was dependent on the size of the Baker’s cyst at baseline, with an 83.7% (36/43) probability of resolution for smaller cysts and 52.1% (25/48) probability for larger cysts. Cite this article: Bone Joint J. 2020;102-B(1):132–136
The development of a novel patient-derived recovery scale for open tibial fractures
Authors: Trickett Ryan W. , Mudge Elizabeth , Price Patricia , Pallister Ian 
Published: December 2019

Aims The aim of this study was to develop a psychometrically sound measure of recovery for use in patients who have suffered an open tibial fracture. Methods An initial pool of 109 items was generated from previous qualitative data relating to recovery following an open tibial fracture. These items were field tested in a cohort of patients recovering from an open tibial fracture. They were asked to comment on the content of the items and structure of the scale. Reduction in the number of items led to a refined scale tested in a larger cohort of patients. Principal components analysis permitted further reduction and the development of a definitive scale. Internal consistency, test-retest reliability, and responsiveness were assessed for the retained items. Results The initial scale was completed by 35 patients who were recovering from an open tibial fracture. Subjective and objective analysis permitted removal of poorly performing items and the addition of items suggested by patients. The refined scale consisted of 50 Likert scaled items and eight additional items. It was completed on 228 occasions by a different cohort of 204 patients with an open tibial fracture recruited from several UK orthoplastic tertiary referral centres. There were eight underlying components with tangible real-life meaning, which were retained as sub-scales represented by ten Likert scaled and eight non-Likert items. Internal consistency and test-retest reliability were good to excellent. Conclusion The Wales Lower Limb Trauma Recovery (WaLLTR) Scale is the first tool to be developed from patient data with the potential to assess recovery following an open tibial fracture. Cite this article: Bone Joint J 2020;102-B(1):17–25