bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overhydration and low serum prealbumin predict peritoneal dialysis-related peritonitis in continuous ambulatory peritoneal dialysis patients
Authors: Quy Quyen Dao Bui , Huy Tuan Pham Ngoc , Duc Loc Nguyen , Van My Pham , Huu Dung Nguyen , Duy Toan Nguyen , Viet Tien Tran , Do Quyet , Viet Thang Le 
Published: November 2020

Abstract
Background: In this study, we focused on the role of overhydration (OH) and low serum prealbumin concentration in predicting peritonitis in continuous ambulatory peritoneal dialysis (CAPD) patients over a 3-year period.Methods: We measured serum prealbumin concentration and OH by body composition monitor in 278 CAPD patients (159 males and 119 females) with a mean age of 46 years and a median peritoneal dialysis (PD) duration of 21 months. Cases of PD-related peritonitis were collected over 3 years. Results: After the 3-year follow-up, 44 patients were diagnosed with PD-related peritonitis (15.8%). Low education, serum glucose, prealbumin, and OH were independent risk factors for predicting peritonitis over 36 months in CAPD patients. Based on the ROC curve model and Kaplan-Meier analysis, we realized that low prealbumin and high OH were independent predictors of 3-year peritonitis in CAPD patients (Prealbumin: AUC = 0.838, cut-off value = 32.5 mg/dL, Se= 90.9%, Sp = 32.9%; OH: AUC = 0.851, cut-off value = 1.33 L, Se = 79.5%, Sp = 85.5%; and log-rank test p < 0.001, respectively). Conclusion: Overhydration and low serum prealbumin were the independent predictors of PD-related peritonitis in CAPD patients.
Inflammatory potential of the diet and risk of sarcopenia and its components
Authors: Bagheri Amir , Soltani Sanaz , Hashemi Rezvan , Heshmat Ramin , Motlagh Ahmadreza Dorosty , Esmaillzadeh Ahmad 
Published: November 2020

Abstract
Background: Despite a large body of evidence on the link between dietary inflammatory index (DII) and several chronic conditions, limited data are available about the association of DII and sarcopenia. This study aimed to examine the relationship between inflammatory potential of the diet (as measured by DII) and sarcopenia and its components among community-dwelling elderly population.Methods: This population-based cross-sectional study was performed in 2011 among 300 elderly people (150 men and 150 women) aged ≥55 years, who were selected using cluster random sampling method. Dietary assessment was done using a pre-tested food frequency questionnaire. Energy-adjusted DII was calculated based on earlier studies. Sarcopenia and its components were determined based on the European Working Group on Sarcopenia (EWGSOP) definition.Results: Mean age of study participants was 66.7 ± 7.7 y. Subjects in the highest tertile of DII score (i.e. those with a more pro-inflammatory diet) were more likely to be older (P=0.02). The prevalence of sarcopenia (P=0.016) and low muscle mass (P=0.041) was significantly higher among subjects in the top tertile compared with those in the bottom tertile of DII. After adjustment for potential confounders, those with the highest DII were 2.18 times (95% CI: 1.01-4.74) more likely to have sarcopenia than those with the lowest DII. With regard to components of sarcopenia, subjects in the top tertile of DII had not significantly greater odds of low muscle mass (OR: 1.38; 95% CI: 0.72-2.63), abnormal handgrip strength (OR: 0.97; 95% CI: 0.49-1.89), and abnormal gait speed (OR: 1.61; 95% CI: 0.84-3.08) than those in the bottom tertile.Conclusions: In conclusion, a diet with more pro-inflammatory potential was associated with a greater odds of sarcopenia. Further studies are required to confirm these findings.
CircCDKN2B-AS1 interacts with IMP3 to stabilize Hexokinase 2 mRNA and facilitate cervical squamous cellcarcinoma aerobic glycolysis progression
Authors: Zhang Yanan , Zhao Lu , Yang Shizhou , Cen Yixuan , Zhu Tingjia , Wang Lingfang , Xia Lili , Liu Yuwan , Zou Jian , Xu Junfen , Li Yang , Cheng Xiaodong , Lu Weiguo , Wang Xinyu , Xie Xing 
Published: November 2020

Abstract
Background: Circular RNAs (circRNAs) have been reported to play key roles in the development of various cancers. However, the biological functions and clinical significance of most circRNAs are still elusive. The purpose of this study was to explore the function and mechanism of a certain circRNA named circCDKN2B-AS1 in cervical cancer development and its potential value in the clinic.Methods: qRT-PCR was used to verify the expression level of circCDKN2B-AS1. CCK-8, Transwell, and flow cytometry (FCM) assays were performed to detect cellular proliferation, migration, and apoptosis, respectively. A Seahorse XFe96 Analyzer was used to measure glycolysis metabolism level. RNA pull-down, RNA immunoprecipitation (RIP), actinomycin-D addition assays and Western blotting were used to screen and elucidate the potential mechanisms involved. BALB/c nude mice and zebrafish embryos (AB, WT) were used as animal models to investigate tumorigenesis capability. 18FDG-microPET/CT imaging and lactic acid (LA) and pyruvic acid (PA) content detection assays were used to detect the level of glucose metabolism in subcutaneous tumors from nude mice.Results: CircCDKN2B-AS1, a circular isoform of the long noncoding RNA (lncRNA) CDKN2B-AS1, was upregulated in cervical cancer and precancerous tissues. We found that circCDKN2B-AS1 associated with the IMP3 protein depending on a specific binding site and regulated the stability of Hexokinase 2 (HK2) mRNA, the rate-limiting enzyme of the aerobic glycolysis pathway. The expression level of circCDKN2B-AS1 fated the binding of IMP3 to the 3’ untranslated region (UTR) of HK2 mRNA, consequently affecting the malignant cell phenotype and aerobic glycolysis in cervical cancer in vitro and in vivo. Mutant circCDKN2B-AS1, lacking the IMP3 binding site, did not have such effects. Utilization of an inhibitory peptide to block the interaction between circCDKN2B-AS1 and the IMP3 protein impeded the binding of IMP3 to the 3’UTR of HK2 mRNA and suppressed aerobic glycolysis in cervical cancer cells.Conclusions: Our findings demonstrate that circCDKN2B-AS1 facilitates aerobic glycolysis by sponging the IMP3 protein to stabilize HK2 mRNA, consequently promoting the malignant phenotype in cervical cancer, which may provide a potential approach for cervical cancer therapeutics.
TRIM25 regulates oxaliplatin resistance in colorectal cancer by promoting EZH2 stability
Authors: Zhou Sha , Peng Jianhong , Xiao Liuniu , Zhou Caixia , Fang Yujing , Ou Qingjian , Qin Jiayi , Liu Mengzhong , Pan Zhizhong , Hou Zhenlin 
Published: November 2020

Abstract
BackgroundResistance to chemotherapy remains the major cause of treatment failure in patients with colorectal cancer (CRC). Tripartite motif containing 25 (TRIM25), an E3-ubiquitin ligase, has been reported to play a vital role in tumorigenesis. The present study aimed to explore the function and mechanism of TRIM25 in regulating oxaliplatin resistance in colorectal cancer.MethodsThe expression of TRIM25 in colorectal cancer tissues was examined using publicly available datasets, immunohistochemistry, and western blotting. Further survival analysis was conducted using the Kaplan-Meier method. CCK8 assays, colony-formation assays, Annexin V-FITC /PI staining and xenograft tumor models were used to evaluate the sensitivity of CRC cells to oxaliplatin. Sphere-formation assays, RT-PCR and limiting dilution assays were used to evaluate the influence of TRIM25 on the stem cell properties of CRC cells. Co-immunoprecipitation, polyubiquitination assays and western blotting were used to determine the mechanism by which TRIM25 regulates EZH2.ResultsPatients with high expression of TRIM25 had a significantly higher recurrence rate (28.9% vs. 15.0%, P = 0.012) and worse disease-free survival (P = 0.006) than those with low TRIM25 expression. Downregulation of TRIM25 dramatically inhibited, while overexpression of TRIM25 increased, CRC cell survival after oxaliplatin treatment. In addition, TRIM25 promoted the stem cell properties of CRC cells both in vitro and in vivo. Importantly, we demonstrated that TRIM25 inhibited the binding of E3-ubiquitin ligase TRAF6 to EZH2, thus stabilizing and upregulating EZH2, and promoting oxaliplatin resistance.ConclusionsOur study provided evidence that TRIM25 is a novel epigenetic regulator of oxaliplatin resistance. Targeting TRIM25 might be a promising strategy for CRC treatment.
Morphofunctional Cardiac Changes in Singleton and Twin Pregnancies: A Longitudinal Cohort Study
Authors: umazume takeshi , Yamada Takahiro , Furuta Itsuko , Iwano Hiroyuki , Morikawa Mamoru , Watari Hidemichi , Minakami Hisanori 
Published: November 2020

Abstract
Background: This study aimed to compare the echocardiographic changes and cardiac biomarkers between women with singleton and twin pregnancies.Methods: From April 2014 to March 2016, this longitudinal cohort study invited pregnant women who were scheduled to give birth at Hokkaido University Hospital. We analyzed prospectively collected data on simultaneously determined echocardiographic parameters and blood cardiac markers of 44 women with singleton and 22 women with twin pregnancies. Furthermore, we tested the mixed-effect models for echocardiographic parameters and cardiac biomarkers.Results: During the third trimester and immediately postpartum (within 1 week after childbirth), the mean left atrial volume index and brain natriuretic peptide (BNP) level were significantly higher in women with twin pregnancies than in those with singleton pregnancies. Women with twin pregnancies also had significantly smaller second-trimester inferior vena cava diameters and significantly higher third-trimester creatinine levels than those with singleton pregnancies. BNP positively correlated with the left atrial volume index (β = 0.49, p < 0.01) and the ratio of early diastolic transmitral to mitral annular velocity (E/e') (β = 0.41, p < 0.01). At 1 month after childbirth in women with singleton pregnancies, BNP and N-terminal precursor protein BNP (NT-proBNP) fragments immediately postpartum negatively correlated with the later E/e' (r = −0.33, p = 0.02 and r = −0.36, p < 0.01, respectively).Conclusions: The intravascular cardiac load reached maximum within 1 week after childbirth and was greater in women with twin pregnancies than in those with singleton pregnancies. BNP/NT-proBNP significantly positively correlated with LA volume index and E/e'. In women with singleton pregnancies, BNP secreted immediately after childbirth might improve the diastolic functions 1 month after childbirth.
Transcriptome Sequencing and Differential Expression Analysis Reveal Molecular Mechanisms for Seed Starch Accumulation in Chinese Chestnut Metaxenia
Authors: Li Shengxing , Shi Zhuogong , Zhao Zhiheng , Zhu Qiurong , Tao Liang , Liang Wenhui 
Published: November 2020

Abstract
Background: Chestnut is an important kind of edible nut rich in starch and protein. The characteristics and nutrient contents of chestnut have been found to show obvious metaxenia effects in previous studies. To improve the understanding of the metaxenia effect on chestnut starch and sucrose metabolism, this study used three varieties of chestnut, ‘Yongfeng 1’, ‘Yong Renzao’ and ‘Yimeng 1’, as male parents to pollinate ‘Yongfeng 1’, as the female parent, and studied the mechanisms of starch and sucrose metabolism in three starch accumulation stages (70 (S1), 82 (S2), and 94 (S3) days after pollination , DAP) in the chestnut seed kernel.Result: Most carbohydrate metabolism genes were highly expressed in YFF in stage S2 and in YFR and YFM in stage S3. In stage S3, hub genes encoding HSF_DNA-binding, ACT, Pkinase, and LIM proteins and four transcription factors were highly expressed, with YFF showing the higest expression, followed by YFR and, finally, YFM. In addition, transcriptome analysis of the kernels at 70, 82 and 94 DAP showed that the starch granule-bound starch synthase (EC 2.4.1.242) and ADP-glucose pyrophosphorylase (EC 2.7 .7.27) genes were actively expressed at 94 DAF. Chestnut seeds regulate the accumulation of soluble sugars, reducing sugars and starch by controlling glycosyl transferase and hydrolysis activity during development.Conclusion: These studies and resources have important guiding significance for further research on starch and sucrose metabolism and other types of metabolism related to chestnut metaxenia.
The Association of Metabolic Syndrome and Cognitive Impairment in Jidong of China: A Cross-Sectional Study
Authors: Wang Xiaohui , Ji Long , Ding Guoyong , Chen Xueyu , Chen Yanru , Li Dong 
Published: November 2020

Abstract
Background: Metabolic syndrome (Mets) is prevalent in the general population and has been reported to be an independent risk factor for cognitive impairment. This study aimed to investigate the association of Mets with the risk of cognitive impairment.Methods:We studied 5,854 participants from the Jidong community. Cognitive function was assessed by the Mini-Mental State of Examination (MMSE) scale. Mets was diagnosed according to the International Diabetes Federation criteria. We used logistic regression analysis to investigate the association of metabolic syndrome with the risk of cognitive impairment.Result: Among the 5,854 adults included in the study, the age mean (SD) of age was 44 (13.57) years, and 2,916 (50.34%) were male. There was a higher (56.03%) cognitive impairment incidence rate among participants with Mets than among those without Mets. In addition, there was a significant association between Mets and cognitive impairment (OR: 2.39, 95% CI: 2.00 - 2.86, P < 0.05) after adjusting for potential confounders, including age, gender, education level, marital status, smoking and alcohol consumption status. Regarding the 5 Mets components, abdominal obesity and elevated blood pressure were associated with the risk of Mets (OR: 1.36, 95% CI: 1.09-1.70, P < 0.001; OR: 1.32, 95% CI: 1.07 - 1.63, P < 0.05). Moreover, the strongest statistical correlation (adjusted OR: 1.86, 95% CI: 1.22 - 2.83, P < 0.05) was found when the number of Mets components was three.Conclusion: Our study suggested that Mets was associated with cognitive impairment and that abdominal obesity and hypertension were associated with an increased risk of cognitive impairment.
Evidence of wave particle duality in human brain dynamics
Authors: Pal Mayukha , . Neeraj , Panigrahi Prasanta 
Published: November 2020

Abstract
Clear evidence of wave-particle duality in the brain dynamics is demonstrated for the first time, from the EEG signals of healthy individuals and epileptic patients. The low frequency components exhibit particle type behaviour in a phase-space description, with the potentials as coordinates and their instantaneous changes as the corresponding velocities. The closed paths reveal periodic motion, well described by one linear oscillator or possibly coupled ones with limit cycle dynamics and synchronization at the macroscopic level. The epileptic patients reveal dynamical features of bi-stability, originating from non-linearity, a prominent feature in the signals from the epileptogenic zone and much enhanced during the periods of seizure. Analogy from the phase-space of oscillator dynamics reveals dominance of potential energy in the signals from the epileptogenic zone, as also in the patients during occurrence of seizure. The acceleration, arising from the change of velocity, is found to be particularly strong in epileptic patients, when the phase space shows bi-stability and bursty behaviour. Wave behaviour with characteristics of superposition emerges in the frequency range corresponding to the observed unstable periodic orbits, that appear at the boundary of alpha and beta waves of 8-14Hz, centred at 10Hz. A modulated carrier wave is observed for all subjects at 18Hz, higher in width for patients. Coherent wave dynamics, with interference playing a key role in the wave packet collapse and revival, is observed starting from 18Hz, with the coherence getting significantly enhanced around 40-45Hz. Mechanism of intra frequency energy transfer is shown to be neutral turbulence.
EXPERIÊNCIA CÊNICA E CULTURA DIGITAL: POSSIBILIDADES TEATRAIS EM MEIOS VIRTUAIS
Authors: Lopes Hannah 
Published: November 2020

O texto apresenta reflexões sobre o universo da cultura digital e as possibilidades de criação e produção teatral mediadas pela tecnologia, a partir das experiências cênicas que surgiram no contexto pandêmico vivido no ano de 2020 pela disseminação do coronavírus. Com foco investigativo na experiência vivenciada com o experimento cênico-digital Enquanto a Festa não Chega, do Laboratório de Pesquisa e Criação Cênica - Cri’Ative’Se Lab. (Recife/PE). Caracteriza-se como uma pesquisa do tipo qualitativa, buscando um diálogo relacional entre o teatro e seus moldes já conhecidos, em interação com os meios virtuais. Utilizando como procedimento o estudo bibliográfico sobre cultura, cultura digital e as teatralidades contemporâneas; o recolhimento de discussões sobre o tema dispostos nas redes, o depoimento dos colegas participantes da experiência; e a análise das similaridades e diferenças com a hibridização dessas formas. Sob essa perspectiva, foi possível identificar a capacidade transgressora do fazer teatral com uma nova percepção de presença, tempo e espaço – tão caros ao teatro -, a partir do estabelecimento de uma conexão diferenciada entre artistas e espectadores nas experiências mediadas pelos recursos tecnológicos. Surgindo assim, novas possibilidades e formas de criação e produção para o teatro.
Memória Pandêmica
Authors: LEONARDELLI PATRICIA 
Published: November 2020

O artigo apresenta a descrição e análise pedagógica e artística do projeto "Memória Pandêmica - dramaturgias da memória e do caos”, desenvolvido pela autora junto ao Departamento de Arte Dramática do Instituto de Artes, UFRGS. O processo de criação se apropria da rede social Instagram para desdobrar algumas questões centrais da pesquisa sobre trabalho de ator em desenvolvimento presencial, e sugere caminhos por onde as investigações na área podem encontrar as adaptações necessárias para seguir ativas em tempos de presencialidade remota.
Sprawność fizyczna dzieci wiejskich i miejskich z niskiej grupy społeczno-ekonomicznej na Jukatanie (Meksyk)
Authors: Aftanasiuk Maryla 
Published: November 2020

Body build and physical fitness of schoolchildren of low socioeconomic strata from urban and rural areas of Yucatan were studied. The material consisted of 552 children from Merida (the capital city of Yucatan State, Mexico) and of 526 children from the Yaxcaba horticultural community, 7 through 14 years of age. These are cross-sectional samples studied in 1996-97 in Merida and in 1999 and 2000 in Yaxcaba. The ethnic origin was evaluated using two surnames of children (from the father and mother side). The studied variables included stature, BMI, arm circumference, grip strength, agility run, Sargent vertical jump index (explosive strength), spine flexibility index, and reaction time. Urban children are significantly taller than rural ones, and BMI and arm circumference show also a tendency to be greater in urban areas. Physical fitness tests are better performed (better results) in rural areas than in urban ones. If the whole material is divided according to two ethnic groups (Mayas and Mestizos, and Creoles) the differences in body build are still observed but those in physical fitness disappeared. Creole children are taller than Mayas and Mestizos and they show a tendency to have more weight for height and greater arm circumference. Generally, the differences in physical fitness are only observed between rural and urban children what may be caused by a more active way of life in villages than in towns resulting from agricultural activity. However, differences in stature are observed between ethnic as well as between rural and urban groups. This may have the genetic origin (Creoles and Mayas), and in the case of different localities, it may also be caused by more various nutrition in towns than in villages.
Moral Aspects of Some Combat Sports
Authors: Meller Jacek 
Published: November 2020

Nowadays, sport is very popular as a way of spending free time, taking care of one’s health and physical condition, as well as being an entertainment worth watching; sport is also judged positively, when it comes to moral aspects. However, there are disciplines that may cause doubts, because of the possible risk for the contestants (e.g. extreme sports), especially combat sports. The purpose of this article is to present an ethical analysis of full-contact combat disciplines. Their history shows a process of gradual brutalisation, in antiquity from battles during the Greek Olympics, to competitions in Roman arenas; in the modern age from regulations introduced in the 19th century and the beginning of the 20th century, to formation or restoration of combat, where almost no rules exist. Rules that apply in modern combat sports, lead to aggressive behaviour towards rivals, and give an advantage to the person who, not only strikes more technically correct blows or uses grips, but also reduces the opponent’s ability to fight further. It leads to serious injuries whose consequences remain until the end of a contestant’s life and make him a disabled person as time passes. Aggression that seriously harms a contestant, makes it impossible to morally excuse those sports.
LAND USE DEVELOPMENT AND RIDERSHIP AT KELANA JAYA LRT LINE, MALAYSIA
Authors: Abdullah Jamalunlaili , Abdul Rashid Kushairi , Baharom Shah Muhammad Ikram , Ling Oliver Hoon Leh , Abdul Majid Rohayu , Ngah Rohana 
Published: November 2020

Urbanisation has led to increased traffic use and congestion in various cities around the world. Various policies and strategies have been implemented to address the issue. One of the most popular strategies is the development of transit system, including mass rapid transit (MRT) and light rapid transit (LRT). To ensure the success of the transit system, the concept of Transit Oriented Development, in which land uses around the stations that are developed for urban development has been implemented. This paper evaluates a possible relationship between land uses around the station and ridership in selected stations along the Kelana Jaya LRT line in the Kuala Lumpur metropolitan area, Malaysia. The land uses around the station were calculated using Land Use and Public Transport Accessibility Index (LUPTAI). The research did not conclusively find a strong relationship between LUPTAI and ridership. This was perhaps due to the fact that almost all stations had been developed for urban land uses, such as commercial, residential and public facilities, thus giving all stations almost the same index figures. It is hope that a more detailed index that accounts for type and mixture of development on land, as well as the density for residential areas would probably give a better index result, as well as perhaps a stronger relationship with ridership figures.