bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification and Expression Analysis of CD73 Inhibitors in Cervical Cancer
Authors: Iqbal Jamshed , Basharat Ayesha , Bano Sehrish , Abid Syed Mobasher Ali , Pelletier Julie , Sévigny Jean 
Published: September 2020

Aims:
The present study was conducted to examine the inhibitory effects of synthesized
sulfonylhydrazones on the expression of CD73 (ecto-5′-NT).

Background:
CD73 (ecto-5′-NT) represents the most significant class of ecto-nucleotidases, which
are mainly responsible for the dephosphorylation of adenosine monophosphate to adenosine. Inhibition
of CD73 played an important role in the treatment of cancer, autoimmune disorders, precancerous
syndromes, and some other diseases associated with CD73 activity.

Objective:
Keeping in view the significance of CD73 inhibitor in the treatment of cervical cancer, a
series of sulfonylhydrazones (3a-3i) derivatives synthesized from 3-formylchromones were evaluated.

Methods:
All sulfonylhydrazones (3a-3i) were evaluated for their inhibitory activity towards CD73
(ecto-5′-NT) by the malachite green assay and their cytotoxic effect was investigated on the HeLa cell
line using MTT assay. Secondly, the most potent compound was selected for cell apoptosis, immunofluorescence
staining, and cell cycle analysis. After that, CD73 mRNA and protein expression were
analyzed by real-time PCR and Western blot.

Results:
Among all compounds, 3h, 3e, 3b, and 3c were found to be the most active against rat-ecto-
5′-NT (CD73) enzyme with IC50 (μM) values of 0.70 ± 0.06 μM, 0.87 ± 0.05 μM, 0.39 ± 0.02 μM,
and 0.33 ± 0.03 μM, respectively. These derivatives were further evaluated for their cytotoxic potential
against cancer cell line (HeLa). Compounds 3h and 3c showed the cytotoxicity at IC50 value of
30.20 ± 3.11 μM and 86.02 ± 7.11 μM, respectively. Furthermore, compound 3h was selected for cell
apoptosis, immunofluorescence staining, and cell cycle analysis, which showed a promising apoptotic
effect in HeLa cells. Additionally, compound 3h was further investigated for its effect on the expression
of CD73 using qRT-PCR and western blot.

Conclusion:
Among all synthesized compounds (3a-3i), Compound 3h (E)-N'-((6-ethyl-4-oxo-4Hchromen-
3-yl) methylene)-4-methylbenzenesulfonohydrazide was identified as the most potent compound.
Additional expression studies conducted on the HeLa cell line proved that this compound
successfully decreased the expression level of CD73 and thus, inhibited the growth and proliferation
of cancer cells.
Design and Usability Evaluation of Mobile Voice-Added Food Reporting for Elderly People: Randomized Controlled Trial
Authors: Liu Ying-Chieh , Chen Chien-Hung , Lin Yu-Sheng , Chen Hsin-Yun , Irianti Denisa , Jen Ting-Ni , Yeh Jou-Yin , Chiu Sherry Yueh-Hsia 
Published: September 2020

Background
Advances in voice technology have raised new possibilities for apps related to daily health maintenance. However, the usability of such technologies for older users remains unclear and requires further investigation.

Objective
We designed and evaluated two innovative mobile voice-added apps for food intake reporting, namely voice-only reporting (VOR) and voice-button reporting (VBR). Each app features a unique interactive procedure for reporting food intake. With VOR, users verbally report the main contents of each dish, while VBR provides both voice and existing touch screen inputs for food intake reporting. The relative usability of the two apps was assessed through the metrics of accuracy, efficiency, and user perception.

Methods
The two mobile apps were compared in a head-to-head parallel randomized trial evaluation. A group of 57 adults aged 60-90 years (12 male and 45 female participants) was recruited from a retirement community and randomized into two experimental groups, that is, VOR (n=30) and VBR (n=27) groups. Both groups were tested using the same set of 17 food items including dishes and beverages selected and allocated to present distinct breakfast, lunch, and dinner meals. All participants used a 7-inch tablet computer for the test. The resulting data were analyzed to evaluate reporting accuracy and time efficiency, and the system usability scale (SUS) was used to measure user perception.

Results
For eight error types identified in the experiment, the VBR group participants were significantly (P<.001) more error prone owing to the required use of button-tapping actions. The highest error rates in the VOR group were related to incomprehensible reporting speech (28/420, 6.7%), while the highest error rates in the VBR group were related to failure to make required button taps (39/378, 10.3%). The VOR group required significantly (P<.001) less time to complete food reporting. The overall subjective reactions of the two groups based on the SUS surpassed the benchmark and were not significantly different (P=.20).

Conclusions
Experimental results showed that VOR outperformed VBR, suggesting that voice-only food input reporting is preferable for elderly users. Voice-added apps offer a potential mechanism for the self-management of dietary intake by elderly users. Our study contributes an evidence-based evaluation of prototype design and selection under a user-centered design model. The results provide a useful reference for selecting optimal user interaction design.

Trial Registration
International Standard Randomized Controlled Trial Registry ISRCTN17335889; http://www.isrctn.com/ISRCTN17335889.
Sifat Antimikroba dan Pengaruh Perlakuan Bahan Baku terhadap Rendemen Minyak Sereh Wangi (Antimicrobial Properties and Effects of Raw Material Treatments on Citronella Oil Yield)
Authors: Shintawati Shintawati , Rina Oktaf , Ermaya Dewi 
Published: September 2020

Citronella oil is one of the non-timber forest products (NTFP) and commercially obtained from the distillation of the leaves of the Cymbopogon nardus L. This study aims to determine the effect of the size of the distillation raw material and storage time of the raw material on yield and determine the antimicrobial properties of citronella oil from plants in the production forest Register 40 KPH Gedong Wani, Lampung Selatan Regency. The research was conducted using a complete randomized block design (RAKL) with two factors, namely the size of the distillation raw material (whole leaf, 5 cm, 10 cm, and 15 cm) and the storage time of the raw material (fresh, 2 days, and 4 days) which was carried out in 3 replications. The variables measured were yield, specific gravity, and solubility of citronella oil in alcohol. The inhibition ability test of citronella oil against bacteria using essential oil obtained from distillation at the highest yield conditions, namely fresh leaves and leaf size of 5 cm using the diffusion well method. The results showed that the storage time factor, the size of the distillation raw material, and the interaction between the storage time and the size of the raw material had a significant effect on the yield of citronella oil. The highest yield of citronella oil was achieved in the condition of fresh leaves with a size of 5 cm, namely 2,09%. Density and solubility in alcohol of citronella oil produced met SNI 06-3953-1995 standard, respectively 0,8718-0,8928 g/ ml and 1:2. Citronella oil has strong antibacterial properties against Propioni acne, Escherichia coli, Staphylococcus aureus, and Bacillus cereus with inhibition zone diameters were 40,20 mm, 18,36 mm, 13,07 mm, and 18,80 mm, respectively. Citronella oil from plants in Register 40 KPH Gedong Wani has potential as a raw material for the cosmetic and disinfectant industry. Keywords: antimicrobial, citronella oil, yield
THE INTERRUPTION USED BY THE HOST AND GUESTS IN SARAH SECHAN TALK SHOW ON NET TV
Authors: MAGHFIRO ANNISA ANGGIA AYU , Meisuri Meisuri , Natsir Muhammad 
Published: September 2020

This research aims to identify the types and reasons of interruption uttered by host and the guests in Sarah Sechan talk show. To answer the objectives of the research, the researcher used conversation analysis approach. The data were the utterances that contain the interruption from the conversation in Sarah Secham Talk Show Net TV. The findings showed that there were four types of interruption employed by the host and guests, i.e. simple interruption, overlap interruption, silent interruption and butting-in interruption. From 56 data found in the talk show, simple interruption had the biggest number of occurrence with 37.50%. Simple interruption was the most appearing type in this talk show because each guest in every episode mainly gives his/her floor to the interrupter, which is the host, Sarah sechan even though his/her utterance was disrupted. The smallest number of interruption’s type was butting-in interruption with only 5.35%. The host or the guests seldom do butting-in interruption because they give a chance to the interrupter to deliver his/her message. To decide the reason of interruption, the writer looked at the context of the discussion between the host and the guests. The common reason was Completing with 35.71% and the other reason was showing agreement, seeking clarification, correcting, breaking up, and reject some point. From all of this reason the writer conclude that the interruptions in this talk-show were not violation. Keywords: conversation analysis; interruptionn; Sarah Sechan Talk
An atypical case of AA amyloidosis and its association with pulmonary silicosis
Authors: Guimarães Filipa , Silva Miguel Borges , Correia-Pinto João , Branco Ana , Furtado António , Magalhães Fátima , Barreto José Vasco , Calisto Raquel , Pereira Nídia 
Published: September 2020

Background:
Amyloid fibrils are protein polymers. Functional amyloids play a beneficial role in a variety of physiologic processes. Amyloidosis results from the accumulation of pathogenic amyloids in a variety of tissues.

Case Presentation:
The authors present a case of a 60-year-old male with a pseudotumoral silicosis, a history of intermittent fever, and renal insufficiency with intermittent proteinuria (maximum of 3 g/dl). The diagnosis of amyloidosis was made from multiple biopsies. During the investigation, it was never possible to characterize the subtype of amyloidosis [the patient had findings either in favor of AL amyloidosis and AA amyloidosis (AA)]. A definite diagnosis was only obtained from an autopsy, and AA was found to be the subtype.

Conclusion:
At the time of this publication and to the best of authors’ knowledge, AA has never been described to be associated with pseudotumoral form of pulmonary silicosis. We believe that an inflammatory response associated with pulmonary silicosis was the trigger to the development of AA.
Bizarre bleeps-a case report of propofolinduced urine discoloration following a single dose
Authors: Greenstein Alan Michael , Heaton Daniel 
Published: September 2020

Background:
Green discoloration of urine following propofol use is a rare yet benign side effect. While rare with propofol infusions, it is even less recognized following single doses of propofol and can cause anxiety for both patients and healthcare professionals.

Case Presentation:
This paper presents the case of a patient with alcohol-induced liver cirrhosis who transiently produced green urine following a single dose of propofol at the induction of anesthesia. The exact incidence and mechanism are not known; however, it is thought to be due to the extrahepatic pharmacokinetics associated with propofol metabolism and clearance. Due to its rarity, it can propagate anxiety and lead to unnecessary investigations.

Conclusion:
Propofol is a very commonly used anesthetic drug. The case highlights that the prompt recognition of this rare adverse effect can prevent unnecessary investigations and provide reassurance to the patient and healthcare providers.
PENERAPAN RANTAI DINGIN SERTA SANITASI DAN HYGIENE UNTUK MENINGKATKAN KUALITAS HASIL TANGKAPAN NELAYAN DESA TAGALAYA
Authors: Akerina Febrina Olivia , Kour Femsy 
Published: September 2020

Desa Tagalaya merupakan salah satu Desa di Kecamatan Tobelo yang masyarakatnya bermata pencaharian sebagai nelayan. Cara penangkapan menggunakan alat tangkap sederhana dan armada penangkapanpun masih tradisional, dengan demikian proses penanganan, sanitasi dan hygiene belum dilakukan secara efektif dan efisien. Secara umum, masyarakat desa Tagalaya tidak menggunakan es karena lokasi penangkapan ikan dan penjualan dekat. Kegiatan ini bertujuan untuk meningkatkan pengetahuan nelayan mengenai pentingnya penerapan rantai dingin (Cold Chain System) serta sanitasi dan hygiene, sehingga nilai jual hasil tangkapan tinggi dan berkualitas baik. Metode pelaksanaan kegiatan pengabdian adalah melalui kegiatan penyuluhan dan diskusi. Penyampaian materi mengenai sistem rantai dingin meliputi konsep rantai dingin, dampak tidak diterapkannya rantai dingin terhadap hasil tangkapan. Sedangkan cakupan materi mengenai sanitasi dan hygiene hasil tangkapan adalah pengertian dan ruang lingkup sanitasi dan hygiene serta dampak penerapan sanitasi dan hygiene. Hasil kegiatan yakni masyarakat antusias menerima kateri yang disampaikan, beberapa diantara mereka berkomitmen untuk menerapkan materi yang didapat untuk meningkatkan nilai jual hasil tangkapan.
Kata kunci: Desa Tagalaya, Rantai dingin, Sanitasi dan hygiene, Penanganan ikan
ABSTRACT
Tagalaya is one of the Village in Tobelo sub-district whom its inhibitants did fisheries for living. Their fishing method were simple and conventional, also their handling method, sanitation and hygiene practice were not effective and efficient. Commonly, Tagalaya inhibitants are not using ice for initial handling because fishing areas and selling location nearby. The aim of this activity was to increase the fisheries knowledge about the importance of cold chain system, sanitanion and hygiene of their catches, it can affect its selling price and quality. This activity was carried out in form of counseling and discussion. The theory about cold chain system and its impact if it cannot applied; the scope of sanitation and hygene and its positive impact were delivered. The result of this activity was the fisheries are very enthusiastic and commited to apply the theory in their fishing activity (fishing handling) to increase fish selling price.
Keywords: Tagalaya, Cold Chain, Sanitation and Hygiene, Fish handling
DISEMINASI INOVASI OLAHAN PRODUK MAKANAN BERBAHAN DASAR JAGUNG DI NAGARI GIRI MAJU KABUPATEN PASAMAN BARAT
Authors: Hayati PK Dewi , Aprialis Aprialis , Liyana Desi , Rahmi Ira Desri 
Published: September 2020

Jagung merupakan tanaman serealea yang digunakan sebagai bahan baku industri pangan dan non-pangan. Biji jagung merupakan hasil panen tanaman jagung yang biasanya dijual dalam bentuk tongkol atau pipil. Sebagai penghasil jagung utama di Sumatera Barat, belum banyak produk olahan jagung yang ditemukan di Kabupaten Pasaman Barat. Kegiatan pemberdayaan masyarakat ini bertujuan untuk mendiseminasikan dan mendorong berbagai inovasi produk olahan makanan dari jagung pada masyarakat Nagari Giri Maju, Kabupaten Pasaman Barat melalui kegiatan Kuliah Kerja Nyata (KKN) Dikti. Metode diseminasi teknologi yang diterapkan adalah berupa demonstrasi dan pelatihan, penyuluhan dan pendampingan masyarakat. Hasil menunjukkan bahwa kegiatan yang dilakukan (1) berhasil mendiseminasikan berbagai inovasi produk makanan berbahan dasar jagung pipil dan tepung jagung, dan (2) masyarakat baru mampu berinovasi menghasilkan produk olahan jagung yang memiliki daya tahan/simpan yang rendah. Perlu dukungan pemerintah daerah dan partisipasi aktif masyarakat untuk keberlanjutan program menjadikan kabupaten Pasaman Barat tidak hanya sebagai penghasil jagung tetapi juga penghasil produk makanan olahan berbahan dasar jagung.
Kata kunci: Diversifikasi, Jagung pipil, Nilai tambah, Produk olahan jagung

ABSTRACT

Corn is an important cereal crop used as the raw material of food and non-food industries. Grain kernel is the harvest of corn plants. As the leading producer of corn in West Sumatera, there are not many processed corn products found in West Pasaman Regency. The community empowerment aimed to disseminate and encourage various innovations processed food products from corn in the Nagari Giri Maju, West Pasaman Regency, through the activities of KKN Dikti. The method of dissemination of technology applied is a demonstration, in-house training, community learning and assistance. Results showed that activities conducted (1) successfully disseminated various innovations of food products based on corn kernel and cornflour, and (2) the community was able to produce corn-processed products that have a low durability/shelf life. To sustain the program that makes the West Pasaman regency as the producer of processed corn products need local government support and active participation of the community.
Keywords: Diversification, Corn kernel, Value added, Corn processed
Kaynak Tüketim Muhasebesi: Seramik Üretim İşletmesinde Bir Uygulama
Authors: KARAKOÇ Mehtap , DARDANOĞLU Elif 
Published: September 2020

Gelişen teknoloji ve pazar ortamı, işletmelerin rekabet koşullarında geri kalmamak amacıyla maliyetleme
sistemlerine verdikleri önemi arttırmıştır. Geleneksel maliyetleme sistemleri otomasyonun artmasıyla birlikte
yeterli bilgiyi işletme yöneticilerine sağlayamamıştır. Bu sebeple 1980lerden itibaren yeni maliyetleme yöntemi
arayışına girilmiştir. Faaliyete Dayalı Maliyetleme (FDM) sistemi bu arayışın parçalarından birisidir. Ancak
daha sonra FDM’nin bazı eksiklikleri nedeniyle Alman Maliyet Muhasebesi (Grenzplankostenrechnung-GPK)
ile “Faaliyete Dayalı Maliyetleme” sistemlerinin birleşmesiyle, maliyet dağıtımında kaynaklara odaklanan ve
atıl kapasiteyi dikkate alan “Kaynak Tüketim Muhasebesi” (KTM) ortaya çıkmıştır. Çalışmamızda seramik
üretimi yapan bir işletmede faaliyete dayalı maliyetleme ve kaynak tüketim muhasebesinin uygulanarak ortaya
çıkan maliyetler karşılaştırılmıştır. Böylece üretilen ürünlerin gerçek maliyetleri belirlenmeye çalışılmıştır.
Analizler sonucunda üretilen ürünler incelendiğinde atıl kapasite farkının en çok yer karosunda ortaya çıktığı
belirlenmiştir.
PEMILIHAN PRESIDEN DAN WAKIL RESIDEN BERDASARKAN UNDANG-UNDANG REPUBLIK INDONESIA NOMOR 7 TAHUN 2017 TENTANG PEMILIHAN UMUM
Authors: Sukimin Sukimin 
Published: September 2020

<p>Tujuan penelitian untuk menganalisis pengaturan pelaksanaan dan persyaratan Calon Presiden dan Wakil Presiden berdasarkan Undang-Undang Pemilu Nomor 7 Tahun 2017 . Pemilu merupakan sarana demokrasi yang sangat penting dalam kehidupan bernegara karena sebagai perwujudan nyata terdapatnya demokrasi. Pemilu dilaksanakan secara berkala merupakan keharusan sebagai sarana demokrasi yang menjadikan kedaulatan sebagai inti dalam kehidupan bernegara. Proses kedaulatan rakyat yang diawali dengan Pemilu dimaksudkan untuk menentukan asas legalitas legimitasi dan kredibelitas bagi pemerintahan yang didukung oleh rakyat. Penelitian ini diharapkan dapat memberikan sumbangan pemikiran dalam penyelenggaraan Pemilu agar tidak bertentangan dengan Konstitusi. Metode penelitian yang digunakan yuridis normatif, spesifikasi penelitian diskripftif analistis, dan metode pengumpulan data analisis kualitatif. Hasil penelitian menunjukkan bahwa penyelenggaraan Pemilihan Presiden dan Wakil Presiden yang diselenggarakan secara serentak bersamaan Pemilihan Legislatif dimaksudkan agar penyelenggaranya lebih efesiensi dan efektif dengan tujuan akan memperkuat sistem presidensial yang dibangun berdasarkan konstitusi, terciptanya <em>checks and balances</em> antara DPR dan presiden. Pemilu serentak hakekatnya tidak bertentangan dengan konstitusi karena dalam konstitusi menyatakan pemilu diselenggarakan setiap lima tahun sekali. Kemudian terkait Persyaratan pengusulan calon Presiden dan Wakil Presiden harus memenuhi ambang batas pencalonan (<em>presidential thres</em><em>h</em><em>old</em><em>)</em><em> </em> hal ini bertolak belakang dengan konstitusi, dimana Calon Presiden dan Wakil Presiden diusulkan oleh Partai Politik atau Gabungan Partai Politik peserta pemilu sebelum dilaksanakannya Pemilu. Dengan adanya ambang batas tersebut otomatis tidak seluruh partai politik terutama partai politik baru tidak dapat mengajukan calon padahal yang bersangkutan sebagai partai politik yang telah dinyatakan sebagai peserta pemilu.</p>
Dynamics and features of manifestation of highly pathogenic avian influenza in the Republic of Tuva
Authors: Lopsan H. O. 
Published: September 2020

The dynamics and features of the manifestation of highly pathogenic avian influenza A/H5N1 were studied on the territory of the Republic of Tuva, where it was first recorded in 2006 in wild migratory waterfowl of the duck family, mainly great crested grebe ducks. In the epizootic process of highly pathogenic avian flu on the territory of the Republic, causal-temporal relationships with the seasonal migration of wild waterfowl from the countries of South-East Asia have been noted. Epizootics of highly pathogenic avian flu were observed in 2006, 2009, 2010, 2014, 2015, 2016. In 2016, as a result of mutation of the H5N1 virus strain, an outbreak of highly pathogenic avian flu of the H5N8 strain was registered. Outbreaks of highly pathogenic avian flu H5 and H7 subtypes simultaneously with low pathogenic subtypes of avian flu H3 were noted in 2014, H9 – in 2013 and 2014. In the study of blood serum of birds in the years officially free from avian flu, antibodies to hemagglutinins of the virus of different subtypes were detected in 11.2-50.0% of cases. Despite the absence of bird mortality, this indicates a constant circulation of avian influenza agent in the body of waterfowl. On the territory of the Republic, avian flu has not spread among poultry due to natural-geographical, socio-economic conditions. The development of distant pasture farming does not provide for the maintenance and breeding of poultry in the unfavorable area of the lake UvsNuur; the local population does not have a tradition of hunting for wild fowl, which prevents contact between wild and domestic birds; there are no lakes or pond reservoirs near the only poultry farm in the Republic with a small stock, which prevents wild waterfowl from entering and passing through flying passages.
DISCHARGE LIQUID, VECTOR OF TOTAL SUSPENDED SEDIMENT (TSS) OF MAYO TSANAGA AT MAROUA (FAR NORTH CAMEROON)
Authors: Etienne Bineli Ambomo , August Ombolo , Guillaume Ewodo Mboudou , Ali Madi , Elisabeth Fita Dassou 
Published: September 2020

Mayo Tsanaga is the Cameroonian part of the Lake Chad Basin ungauged. The knowledge of discharge is essential for the design of hydraulic structures and for hydrological risk prediction. The objective of this study is to evaluate discharge, total suspended sediment and the deduction of the specific sediment yield. The exploration of velocity fields and the differences in the pre and post filtration filter weights were adopted as a methodology. The results revealed that annual discharges of Mayo Tsanaga at Maroua from 2012 to 2014 are respectively 1.94 ± 0.38 m3 /s, 2.18 ± 0.43 m3/s and 0.89 ± 0.17 m3/s. Mayo Tsanaga discharge will be used when sizing the second bridge on this river. Mayo Tsanaga's daily mean concentrations of TSS are respectively 429.384 mg/L ± 12.88 for the year 2013 and 17.45 ± 0.52 mg/L for the year 2014. The corresponding specific sediment yield (SSY) of Mayo Tsanaga are 34.92 t.km-2.year-1 in 2013 and 0.57 t.km-2.year-1 in 2014. The SSY expresses the amount of ground lowering for the whole catchment.