bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ring-widths of Abies at tree-line ecotone reveal three centuries of early winter season temperature changes in Yunnan, China
Authors: Bi Yingfeng , Cory Whitney , Fan Zenxin , Yang Jingchao , Wu Zhikun , Huang Wei , Li Jianwen , Yang Xuefei 
Published: May 2020

AbstractVariation in winter temperature is less well understood than in annual and summer temperatures over long timescales, particularly in low-latitude (0–30° N) montane regions with large spatial and topographic heterogeneity. Understanding these variations could be critical for forest manageemnt in these important tree growing regions. We collected tree-ring cores from Yunnan Province in montane southwest China, to determine how winter temperature has varied in the past and to explore its possible drivers in this region. Six highly correlated site chronologies were combined into a long and well-replicated regional composite (RC) chronology. The RC chronology correlated strongest with mean early winter season temperature (EWST) from November to January during 1959–2015. We applied RC chronology to reconstruct EWST from 1653 to 2015. The reconstruction shows five relatively warm historic intervals (1658–1718, 1743–1755, 1771–1791, 1929–1959, and 1995–2015) and cold intervals (1720–1742, 1792–1852, 1860–1883, 1905–1928, and 1960–1994). The 1950s with six anomalous warm seasons and 1980s with five anomalous cold seasons were the warmest and coldest decades, respectively. The EWST reconstruction generally agreed with other winter temperature reconstructions from nearby areas and with historical documents. Atlantic Multidecadal Oscillation (AMO) might be a key forcing of multidecadal winter temperature variations in montane southwest China over the past three and half centuries. Both warm and cold temperature periods coincide with respective positive and negative phases of AMO. Besides, the cold intervals during the nineteenth and twentieth centuries may also have been influenced by large volcano eruptions in low-latitude regions of south and east Asia. Our EWST reconstruction not only improves our understanding of the trends and variations of winter climate history, but also supports planning for resilience in conservation, agriculture, and forestry management in montane southwest China into the future.
Expression of H3K4me3 and H3K9ac in breast cancer
Authors: Berger Luisa , Kolben Thomas , Meister Sarah , Kolben Theresa M. , Schmoeckel Elisa , Mayr Doris , Mahner Sven , Jeschke Udo , Ditsch Nina , Beyer Susanne 
Published: May 2020

Abstract
Purpose
Breast cancer is the leading cause of cancer death in females. Histone modifications have been shown to have an influence on the gene expression. This study focusses on the histone modifications H3K9ac and H3K4me3 in breast cancer and their impact on survival

Methods
H3K4me3 and H3K9ac expression was immunohistochemically examined in 235 tissue samples.

Results
Positive estrogen receptor status was correlated with a higher IRS of the nuclear (p = 0.033), and of the cytoplasmic H3K4me3 staining (p = 0.009). H3K9ac intensity was associated to the Her2 status (p = 0.045) and to poor prognosis in cells with positive Ki67 status (p = 0.013). A high intensity of nuclear H3K4me3 staining was found to be correlated with a lower 10-year-survival (p = 0.026) and with lower breast cancer-specific survival (p = 0.004). High percentage score (> 190) of H3K9ac expression was correlated to worse breast cancer-specific survival (p = 0.005). Shorter progression-free survival was found in patients with nuclear (p = 0.013) and cytoplasmic H3K4me3expression (p = 0.024) and H3K9ac expression (p = 0.023).

Conclusion
This analysis provides new evidence of histone modifications in breast cancer. High H3K4me3 and H3K9ac expression was correlated with survival rates. Further investigation of histone modifications in breast cancer could lead to a more profound understanding of the molecular mechanisms of cancer development and could result in new therapeutic strategies.
Late-stage groundmass differentiation as a record of magma stagnation, fragmentation, and rewelding
Authors: Mujin Mayumi , Nakamura Michihiko 
Published: May 2020

AbstractIn the 2011 eruption of Shinmoedake of the Kirishima volcano group, sub-Plinian eruptions were followed by lava extrusion with intermittent Vulcanian explosions. The interstices of microlites and relatively large nanolites (> 0.4 nm width) in the groundmass of pyroclasts (“groundmass interstices”) were studied to reveal shallow magmatic processes that lead to different eruption styles. The pumice of the sub-Plinian eruption has the least differentiated groundmass interstices composition. The groundmass interstices of the dense juvenile fragments of the Vulcanian explosions are divided into two groups. The first group is the most differentiated as expected from their lava-like texture, whereas the second group is less differentiated and covers the range of sub-Plinian pumice. The Vulcanian pumice overlaps the dense juvenile fragments despite their high vesicularity. This seemingly contradictory relationship of composition in the interstitial groundmass indicates the clastogenic lava origin of the less-differentiated group of dense juvenile fragments. In contrast, magmas stagnated in the shallow conduit maintained elevated temperature and water content, allowing groundmass interstices to differentiate by microlite growth. These magmas then erupted as pumice in the Vulcanian explosions and were effused as lava that was fragmented by subsequent explosions to be later sampled as a dense juvenile fragment. The groundmass crystallinity increased by 9.1 vol.% in 5–45 days between the sub-Plinian and Vulcanian eruptions, increasing initial melt and magma viscosity from 106.1–7.4 and 107.0–8.3 Pa s to 106.9–8.4 and 108.2–9.7 Pa s, respectively. This viscosity increase by nanolite crystallization could have facilitated the stress fragmentation of conduit magma, leading to Vulcanian explosions. Post-fragmentation expansion of the sub-Plinian pumice could have been suppressed by this viscosity increase, resulting in their low vesicularity. Late-stage groundmass differentiation can thus control shallow magmatic processes.
Do changes in snow conditions have an impact on snowmaking investments in French Alps ski resorts?
Authors: Berard-Chenu Lucas , Cognard Jonathan , François Hugues , Morin Samuel , George Emmanuelle 
Published: May 2020

AbstractThis study investigates the relationship between snow conditions and snowmaking investments for over 100 French Alps ski resorts. Investment trends represent a critical issue in capital-intensive sectors such as the ski industry. The data are based on snow reliability indicators and snowmaking investments covering 1997–2014. Descriptive statistics reveal that snowmaking has been the second investment item for ski resorts regardless of the elevation or ski resort size. The study finds that snowmaking investments are highly negatively correlated to snow conditions of the prior year for small and medium-sized ski resorts. Other factors are also likely to play a significant role in driving snowmaking investment dynamics.
Autoencoder-based image processing framework for object appearance modifications
Authors: Ślot Krzysztof , Kapusta Paweł , Kucharski Jacek 
Published: May 2020

AbstractThe presented paper introduces a novel method for enabling appearance modifications for complex image objects. Qualitative visual object properties, quantified using appropriately derived visual attribute descriptors, are subject to alterations. We adopt a basic convolutional autoencoder as a framework for the proposed attribute modification algorithm, which is composed of the following three steps. The algorithm begins with the extraction of attribute-related information from autoencoder’s latent representation of an input image, by means of supervised principal component analysis. Next, appearance alteration is performed in the derived feature space (referred to as ‘attribute-space’), based on appropriately identified mappings between quantitative descriptors of image attributes and attribute-space features. Finally, modified attribute vectors are transformed back to latent representation, and output image is reconstructed in the decoding part of an autoencoder. The method has been evaluated using two datasets: images of simple objects—digits from MNIST handwritten-digit dataset and images of complex objects—faces from CelebA dataset. In the former case, two qualitative visual attributes of digit images have been selected for modifications: slant and aspect ratio, whereas in the latter case, aspect ratio of face oval was subject to alterations. Evaluation results prove, both in qualitative and quantitative terms, that the proposed framework offers a promising tool for visual object editing.
Early adversity predicts adoptees’ enduring emotional and behavioral problems in childhood
Authors: Paine Amy L. , Fahey Kevin , Anthony Rebecca E. , Shelton Katherine H. 
Published: May 2020

AbstractChildren adopted from the public care system are likely to experience a cluster of inter-related risk factors that may place them on a trajectory of mental health problems that persist across the life course. However, the specific effects of putative risk factors on children’s mental health post-placement are not well understood. We conducted a prospective, longitudinal study of children placed for adoption between 2014 and 2015 (N = 96). Adoptive parents completed questionnaires at approximately 5, 21, 36, and 48 months post-placement. We used time series analysis to examine the impact of pre-adoptive risk factors [adverse childhood experiences [ACEs], number of moves, days with birth parents and in care] on children’s internalizing and externalizing problems, and prosocial behavior over 4 years post-placement. Adoptees’ internalizing and externalizing problems remained consistently high over the 4-year study period, but more ACEs predicted increases in internalizing and externalizing problems. Contrary to expectations, more pre-placement moves and time in care predicted fewer problems over time, but exploratory analyses of interactive effects revealed this was only the case in rare circumstances. We identify pre- and post-removal factors that may incur benefits or have a deleterious impact on adoptees’ outcomes in post-adoptive family life. Our findings provide knowledge for front-line professionals in the support of adoptive families and underscore the vital need for effective early intervention.
Early diagnosis of psoriatic arthritis among psoriasis patients: clinical experience sharing
Authors: Su Yu-Jih 
Published: May 2020

AbstractBackgroundThe early detection of psoriatic arthritis (PSA) poses a challenge to rheumatologists, even when their diagnosis is aided by sonography. In order to facilitate early detection of PSA among patients with psoriasis (PSO), we retrospectively analyzed of the relationships between serological markers and comorbidities in 629 psoriatic patients, 102 of which had PSA, while the other 527 had PSO.ResultsSerological markers were found not to be useful in distinguishing between PSA and PSO (p > 0.05 for all comparisons). The prevalence rate of PSA among PSO patients was around 19.4%. Two components of metabolic syndrome—hyperlipidemia (2.94%) and gout (4.9%)—were significantly more prevalent in PSA patients than in PSO patients (p < 0.05). The odds ratio for PSA is 15.94 in patients with hyperlipidemia with a 95% confidence interval (CI) of 1.64–154.80; meanwhile, the odds ratio for PSA is 3.83 in patients with gout with a 95% CI of 1.19–12.31. Allergic rhinitis (5.88%) was more prevalent in PSA patients than in PSO patients (p < 0.01). The odds ratio was 8.17 in patients with allergic rhinitis with a 95% CI of 2.26–29.50. Plasma hs-miR-210-3p distinguishes PSA from PSO, and its levels can also be distinguished from PSA after treated with anti-TNFα biologics agents (bothp < 0.05).ConclusionsNo clinical available serology markers, but hyperlipidemia, gout, axial spondylopathy (inflammatory back pain), or allergic rhinitis, could differentiate between psoriatic arthritis from psoriasis. Plasma hs-miR-210-3p and comorbidities may differentiate psoriatic arthritis from psoriasis.Key Points• Clinical manifestations and comorbidities are different between psoriatic arthritis and psoriasis only patients.• Traditional serology markers are similar between psoriatic arthritis and psoriasis-only patients.• Plasma hs-miR-210-3p distinguishes PSA from PSO, and its levels can also be distinguished from PSA after treated with anti-TNFα biologics agents in our study.
Involvement of O2·− in the regulation of Polycomb, Trithorax and LEC1, L1L, WUS, WOX5, STM gene expression during somatic embryogenesis induction in M. truncatula
Authors: Orłowska Anna , Kępczyńska Ewa 
Published: May 2020

Abstract2,4-dichlorophenoxyacetic acid (2,4-D), an auxinic herbicide, in many in vitro somatic embryogenesis systems is used to induce embryogenesis. This compound present at a low concentration (0.5 µM) during the induction phase, is necessary forM. truncatulaembryogenic callus formation and, consequently, for embryo development. 2,4-D in higher concentration (5 µM) causes an increase in O2·−accumulation which disturbs the callus and embryos formation. However, above processes are disturbed by DPI, an inhibitor of the NADPH oxidase responsible for the O2·−production. Thus, the aim of this study was to elucidate whether during first week of induction phase the change in the level of O2·−affects the expression of genes encoding Polycomb and Trithorax group proteins and the transcription level of some marker genes for SE. The expression ofPolycombandTrithoraxgroup genes, and coding the transcription factors such as: LEC1, L1L, WUS, WOX5 and STM depends on the O2·−accumulation in explant cells. Disorder of its level by manipulation of the concentration of 2,4-D or DPI disrupts expression of the above-mentioned genes and causes disturbances in the callus growth and development of somatic embryos.
A Review of the Relationship Between CTRP Family and Coronary Artery Disease
Authors: Si Yueqiao , Fan Wenjun , Sun Lixian 
Published: May 2020

Abstract
Purpose of Review
In recent years, a family of adiponectin paralogs designated as C1q/TNF-related protein (CTRP) has attracted increasing attention. They are inflammatory adipocytokines mostly secreted from epicardial adipose tissue, which modulate the development and prognosis of coronary artery disease (CAD). This review summarizes the pathophysiological roles of individual members of the CTRP superfamily in the development of CAD.

Recent Findings
Recent studies have revealed how members of the CTRP family, CTRP1, CTRP3, CTRP5, CTRP9, CTRP12, and CTRP13, can influence both development and progression of CAD by modulating metabolic pathways, influencing immuno-inflammatory response, and regulating cardiovascular functions.

Summary
Research to date has not been sufficient to answer the specific mechanism of the CTRP family in the occurrence and development of CAD. This review explores the evidence of CTRP superfamily regulating different pathophysiology stages of CAD through the immuno-inflammation, glucose and lipid metabolism, and vascular endothelial function.
The implementation of pharmacogenomics into UK general practice: a qualitative study exploring barriers, challenges and opportunities
Authors: Rafi I. , Crinson I. , Dawes M. , Rafi D. , Pirmohamed M. , Walter F. M. 
Published: May 2020

AbstractPharmacogenomics describes interpatient genetic variability in drug responses. Information based on whole genome sequencing will soon open up the field of pharmacogenomics and facilitate the use of genomic information relating to drug metabolism and drug responses. We undertook a qualitative study, aiming to explore the potential barriers, opportunities and challenges facing the implementation of pharmacogenomics into primary care. Semi-structured interviews were undertaken with 18 clinical participants (16 GPs and 2 other clinicians). All interviews were recorded and transcribed verbatim. Using a thematic analysis approach, data items were coded, ordered and themes constructed. Most participants were aged 55–60 years and worked as part-time clinical GPs with other clearly defined roles. The emerging themes covered several areas of concern, including the following: the utility of pharmacogenomics and the value of introducing such testing into primary care; how to educate the primary care workforce and ‘mainstream’ pharmacogenomics; the ethical, legal and social aspects of pharmacogenomics and its impact on patients; and potential impacts on the healthcare system particularly around economics and informatics. Most participants had concerns about pharmacogenomics and felt that there were a number of barriers and challenges to its implementation into routine primary care. Most striking were their concerns around the cost-effectiveness of using pharmacogenomics in primary care. At the same time most recognised the increasing availability of direct-to-consumer testing, and felt that this would drive the need to understand the ethical and social implications of using genomic information in primary care. This study has raised important issues that need to be considered when planning the implementation of pharmacogenomics into clinical practice. Prior to the implementation of genomic testing into day-to-day practice in UK primary care, it is important that considerations around education, cost-effectiveness and informatics are addressed, as well as the impact on patients.
The Balanced Threat Agreement for Individual Externality Negotiation Problems
Authors: Borm Peter , Funaki Yukihiko , Ju Yuan 
Published: May 2020

AbstractThis paper introduces a model to analyze individual externalities and the associated negotiation problem, which has been largely neglected in the game theoretic literature. Following an axiomatic perspective, we propose a solution, as a payoff sharing scheme, called the balanced threat agreement, for such problems. It highlights an agent’s potential influences on all agents by threatening to enter or quit. We further study the solution by investigating its consistency. We also offer a discussion on the related stability issue.
Appraising the Epistemic Performance of Social Systems: The Case of Think Tank Evaluations
Authors: Claveau François , Veillette Andréanne 
Published: May 2020

AbstractThis article elaborates a conceptual framework to systematize the epistemic evaluation of social systems. This framework can be used to structure an evaluation or to characterize and assess existing ones. The article then uses the framework to assess four representative evaluations of think tanks. This meta-evaluation exemplifies how the framework can play its structuring role. It also leads us to general conclusions about the existing evaluations of think tanks. Most importantly, by focusing on the organizational level, existing evaluations miss factors that are situated at the network and ecosystemic levels and that significantly determine how well think tanks serve society in producing and disseminating knowledge relevant to public policy. This conclusion suggests the need for epistemic evaluations of think tank ecosystems.
Throughput Legitimacy and the Duty to Consult: The Limits of the Law to Produce Quality Interactions in British Columbia's EA Process
Authors: Do Minh 
Published: May 2020

AbstractThe duty to consult mandates that the Crown must consult affected Indigenous parties when Crown action may negatively impact Aboriginal rights or title claims. The Supreme Court of Canada (SCC) has emphasized that the duty should be characterized by honourable dealings and good faith negotiations. This article argues that the concept of throughput legitimacy can help evaluate the Crown's conduct in consultation. By analyzing 131 British Columbia Environmental Assessments (BC EAs), this article finds that the Crown struggles to uphold throughput legitimacy from the perspective of Indigenous peoples, particularly in the areas of transparency, accountability and effectiveness.
Interest, Usury, and the Transition from “Muslim” to “Islamic” Banks, 1908–1958
Authors: O'Sullivan Michael 
Published: May 2020

AbstractThis article examines the creation of the first privately-owned Muslim banks in the first half of the twentieth century and the legal debates they instigated among Muslim communities. Whether in Bosnia or India, these banks appeared suddenly in the years immediately before the First World War. They were envisioned as a way to free up Muslim capital for productive ends, and as the means to jumpstart a Muslim economic renaissance. Far from masking their interest transactions, the banks' founders and customers pointed to a range of Islamic legal rulings that justified interest levied on deposits and loans. These rulings varied from one geographic locale to the next, and were expressive of diverse Muslim institutional and legal histories. Yet in an age when the formerly diffuse discursive terrain around interest, usury, and the Islamic foundational sources was shifting towards a consensus that rejected any interest/usury distinction, some of these banks faced acute challenges, particularly in India. There, novel notions of interest-free Islamic economics were articulated from the interwar period, which rejected any form of Muslim interest-banking. In time, the earlier iteration of Muslim interest banking became overshadowed by the new paradigm of “Islamic banks” which purportedly eschewed all financial interest.
Prospection of immunological biomarkers for characterization and monitoring of asymptomatic Leishmania (Leishmania) infantum infection
Authors: da Cunha Gisele Macêdo Rodrigues , Carneiro Mariângela , Pascoal-Xavier Marcelo Antônio , da Rocha Iara Caixeta Marques , Magalhães Fernanda do Carmo , Martins-Filho Olindo Assis , Oliveira Edward , Peruhype-Magalhães Vanessa 
Published: May 2020

AbstractIn areas endemic for Leishmania infantum, an asymptomatic infection may be an indicator of the extent of transmission. The main goal of this study was to evaluate the applicability of measuring circulating immunological biomarkers as an alternative strategy to characterize and monitor L. infantum asymptomatic infections in combination with serological methods. To this end, 179 children from a region endemic for visceral leishmaniasis (VL), aged 1–10 years old, selected from a cross-sectional study, were identified as asymptomatic (n = 81) or uninfected (n = 98) by qPCR and/or serological tests (ELISA using L. infantum soluble antigen and rK39), and, together with serum samples of children diagnosed with VL (n = 43), were subjected to avidity tests and cytokine levels measurement. Avidity rates (AR) ranging from 41 to 70% were found in 29 children (66%) from the asymptomatic group. On the other hand, high AR (above 70%) were observed in 27 children (64%) from the VL group. Logistic Regression and Classification and Regression Tree (CART) analyses demonstrated that lower AR and IFN-γ production associated with higher IL-17A levels were hallmarks in asymptomatic L. infantum infections. Therefore, this study proposes an association of immunological biomarkers that can be used as a complementary strategy for the characterization and monitoring of asymptomatic VL infections in children living in endemic areas.
“Social physiology” for psychiatric semiology: How TTOM can initiate an interactive turn for computational psychiatry?
Authors: Dumas Guillaume , Gozé Tudi , Micoulaud-Franchi Jean-Arthur 
Published: May 2020

Abstract
Thinking through other minds (TTOM) encompasses new dimensions in computational psychiatry: social interaction and mutual sense-making. It questions the nature of psychiatric manifestations (semiology) in light of recent data on social interaction in neuroscience. We propose the concept of “social physiology” in response to the call by the conceivers of TTOM for the renewal of computational psychiatry.