bluuebunny/crossref_metadata_2025_split huggingface dataset:
New historical data on the Teutonic Order crusades in Prussia: geophysical and archaeological research into an earth‐and‐timber stronghold and city of the 1230s at Starogród, northern‐central Poland
Authors: Wiewióra Marcin , Wasik Bogusz , Molewski Paweł , Misiewicz Krzysztof , Małkowski Wiesław , Bogacki Miron 
Published: January 2020

AbstractIn 2016–2018 in Starogród, in historical Chełmno Land in northern‐central Poland, remains were discovered of a stronghold (convent house) of the Knights of the Teutonic Order that was founded in the 1230s. After a search lasting more than 100 years, remains were also discovered of the oldest and repeatedly translocated city of Chełmno, which was founded by the German Knights at the same time. Non‐invasive and archaeological studies were conducted as part of the project Castra Terrae Culmensis, at the edges of the Christian world, whose main aim was to answer central questions concerning the beginnings of the State of the Teutonic Order in Prussia. One specific goal was to discover the oldest location of the aforementioned city, founded in 1232. The article presents the results of geophysical, archaeological and geomatic analyses that confirm historical records in the fourteenth‐century German Chronicle and helped to piece together the history of the place where one of the oldest Teutonic Order earth‐and‐timber strongholds and cities chartered under Chełmno Law stood.
A turn‐on luminescence probe for highly selective detection of an anthrax biomarker
Authors: Liu Xiao , Chen Dong , Wang Chenchen , Tian Nianjuan , Li Zhiqiang , Zhang Ying , Ding Zhi‐Jun 
Published: January 2020

AbstractHighly selective detection of Bacillus anthrax spores has attracted worldwide attention because Bacillus anthrax spores not only are harmful to the health of human beings and animals, but also can be used as biological warfare agents. Here, we report a simple platform by mixing EuCl3·6H2O and sodium polyacrylate in aqueous solution and further investigate its luminescence response towards Bacillus anthrax biomarker dipicolinic acid (DPA) as a turn‐on luminescence probe. Importantly, our probe has good sensitivity, lower detection limit, excellent selectivity as well as great anti‐interference ability due to the great luminescence enhancement of Eu3+. Moreover, a test paper is constructed to realize the purpose of portable detection. These results indicate that our probe is an excellent candidate for sensing DPA.
Effect of footplate neuromuscular electrical stimulation on functional and quality-of-life parameters in patients with peripheral artery disease: pilot, and subsequent randomized clinical trial
Authors: Babber A , Ravikumar R , Onida S , Lane T R A , Davies A H 
Published: January 2020

Abstract

Background
Supervised exercise programmes for intermittent claudication have poor access and limited compliance. Neuromuscular electrical stimulation (NMES) may be an effective alternative. A proof-of-concept study and RCT were conducted.

Methods
In study 1, eligible patients underwent baseline assessment; treadmill testing for initial (ICD) and maximum (MCD) claudication distance; EuroQoL Five Dimensions five-level instrument (EQ-5D-5L™) and Intermittent Claudication Questionnaire (ICQ) assessment; and measurement of ultrasound haemodynamics of the superficial femoral artery. After familiarization with the NMES device, participants underwent a 30-min session of stimulation with concomitant recording of haemodynamic measures at 15 min, and after device cessation. Measurements were repeated after 6 weeks of daily use of NMES. In study 2, consecutive patients underwent baseline assessment before online randomization to a supervised exercise programme only, or adjunctive NMES treatment for 6 weeks, followed by repeat measurements.

Results
Study 1 (20 patients) showed a significant improvement in MCD (46 per cent; P &lt; 0·001) and ICD (71 per cent; P &lt; 0·001). The RCT (42 patients) showed a significant adjunctive benefit of NMES in ICD (46 per cent; P = 0·014). Improvements were seen in the ICQ (9 points; P = 0·009) and EQ-5D-5L™ (P = 0·007) in study 1, and there was a significant adjunctive benefit of NMES on the ICQ score in patients who did supervised exercise (11·2 points; P = 0·031). Blood volume flow and time-adjusted mean velocity increased significantly with the device on (P &lt; 0·050). Overall, NMES compliance exceeded 95 per cent.

Conclusion
Footplate NMES significantly improved walking distance in patients with intermittent claudication when used independently and also as an adjunct to supervised exercise. Registration number: trial 1, NCT02436200; trial 2, NCT02429310 (http://www.clinicaltrials.gov).
Prevention of biliary fistula after partial hepatectomy by transcystic biliary drainage: randomized clinical trial
Authors: Maulat C , Regimbeau J-M , Buc E , Boleslawski E , Belghiti J , Hardwigsen J , Vibert E , Delpero J-R , Tournay E , Arnaud C , Suc B , Pessaux P , Muscari F 
Published: January 2020

Abstract

Background
Biliary fistula is one of the most common complications after hepatectomy. This study evaluated the effect of transcystic biliary drainage during hepatectomy on the occurrence of postoperative biliary fistula.

Methods
This multicentre RCT was carried out from 2009 to 2016 in nine centres. Patients were randomized to transcystic biliary drainage or no transcystic drainage (control). Patients underwent hepatectomy (more than 2 segments) of non-cirrhotic livers. The primary endpoint was the occurrence of biliary fistula after surgery. Secondary endpoints were morbidity, postoperative mortality, duration of hospital stay, reoperation, readmission to hospital, and complications caused by catheters. Intention-to-treat and per-protocol analyses were performed.

Results
A total of 310 patients were randomized. In intention-to-treat analysis, there were 158 patients in the transcystic group and 149 in the control group. Seven patients were removed from the per-protocol analysis owing to protocol deviations. The biliary fistula rate was 5·9 per cent in intention-to-treat and 6·0 per cent in per-protocol analyses. The rate was similar in the transcystic and control groups (5·7 versus 6·0 per cent; P = 1·000). There were no differences in terms of morbidity (49·4 versus 46·3 per cent; P = 0·731), mortality (2·5 versus 4·7 per cent; P = 0·367) and reoperations (4·4 versus 10·1 per cent; P = 1·000). Median duration of hospital stay was longer in the transcystic group (11 versus 10 days; P = 0·042). The biliary fistula risk was associated with the width and length of the hepatic cut surface.

Conclusion
This randomized trial did not demonstrate superiority of transcystic drainage during hepatectomy in preventing biliary fistula. The use of transcystic drainage during hepatectomy to prevent postoperative biliary fistula is not recommended. Registration number: NCT01469442 ( http://www.clinicaltrials.gov).
Impact of cirrhosis in patients undergoing laparoscopic liver resection in a nationwide multicentre survey
Authors: Hobeika C , Fuks D , Cauchy F , Goumard C , Soubrane O , Gayet B , Salamé E , Cherqui D , Vibert E , Scatton O ,   the AFC-LLR-2018 study group, Nomi T , Oudafal N , Kawai T , Komatsu S , Okumura S , Petrucciani N , Laurent A , Bucur P , Barbier L , Trechot B , Nunèz J , Tedeschi M , Allard M-A , Golse N , Ciacio O , Pittau G , Cunha A Sa , Adam R , Laurent C , Chiche L , Leourier P , Rebibo L , Regimbeau J-M , Ferre L , Souche F R , Chauvat J , Fabre J-M , Jehaes F , Mohkam K , Lesurtel M , Ducerf C , Mabrut J-Y , Hor T , Paye F , Balladur P , Suc B , Muscari F , Millet G , El Amrani M , Ratajczak C , Lecolle K , Boleslawski E , Truant S , Pruvot F-R , Kianmanesh A-R , Codjia T , Schwarz L , Girard E , Abba J , Letoublon C , Chirica M , Carmelo A , VanBrugghe C , Cherkaoui Z , Unterteiner X , Memeo R , Pessaux P , Buc E , Lermite E , Barbieux J , Bougard M , Marchese U , Ewald J , Turini O , Thobie A , Menahem B , Mulliri A , Lubrano J , Zemour J , Fagot H , Passot G , Gregoire E , Hardwigsen J , Treut Y-P , Patrice D 
Published: January 2020

Abstract

Background
The aim was to analyse the impact of cirrhosis on short-term outcomes after laparoscopic liver resection (LLR) in a multicentre national cohort study.

Methods
This retrospective study included all patients undergoing LLR in 27 centres between 2000 and 2017. Cirrhosis was defined as F4 fibrosis on pathological examination. Short-term outcomes of patients with and without liver cirrhosis were compared after propensity score matching by centre volume, demographic and tumour characteristics, and extent of resection.

Results
Among 3150 patients included, LLR was performed in 774 patients with (24·6 per cent) and 2376 (75·4 per cent) without cirrhosis. Severe complication and mortality rates in patients with cirrhosis were 10·6 and 2·6 per cent respectively. Posthepatectomy liver failure (PHLF) developed in 3·6 per cent of patients with cirrhosis and was the major cause of death (11 of 20 patients). After matching, patients with cirrhosis tended to have higher rates of severe complications (odds ratio (OR) 1·74, 95 per cent c.i. 0·92 to 3·41; P = 0·096) and PHLF (OR 7·13, 0·91 to 323·10; P = 0·068) than those without cirrhosis. They also had a higher risk of death (OR 5·13, 1·08 to 48·61; P = 0·039). Rates of cardiorespiratory complications (P = 0·338), bile leakage (P = 0·286) and reoperation (P = 0·352) were similar in the two groups. Patients with cirrhosis had a longer hospital stay than those without (11 versus 8 days; P = 0·018). Centre expertise was an independent protective factor against PHLF in patients with cirrhosis (OR 0·33, 0·14 to 0·76; P = 0·010).

Conclusion
Underlying cirrhosis remains an independent risk factor for impaired outcomes in patients undergoing LLR, even in expert centres.
Guidelines for treatment of umbilical and epigastric hernias from the European Hernia Society and Americas Hernia Society
Authors: Henriksen N A , Montgomery A , Kaufmann R , Berrevoet F , East B , Fischer J , Hope W , Klassen D , Lorenz R , Renard Y , Garcia Urena M A , Simons M P 
Published: January 2020

Abstract

Background
Umbilical and epigastric hernia repairs are frequently performed surgical procedures with an expected low complication rate. Nevertheless, the optimal method of repair with best short- and long-term outcomes remains debatable. The aim was to develop guidelines for the treatment of umbilical and epigastric hernias.

Methods
The guideline group consisted of surgeons from Europe and North America including members from the European Hernia Society and the Americas Hernia Society. The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach, the Scottish Intercollegiate Guidelines Network (SIGN) critical appraisal checklists, and the Appraisal of Guidelines for Research and Evaluation (AGREE) instrument were used. A systematic literature search was done on 1 May 2018, and updated on 1 February 2019.

Results
Literature reporting specifically on umbilical and epigastric hernias was limited in quantity and quality, resulting in a majority of the recommendations being graded as weak, based on low-quality evidence. The main recommendation was to use mesh for repair of umbilical and epigastric hernias to reduce the recurrence rate. Most umbilical and epigastric hernias may be repaired by an open approach with a preperitoneal flat mesh. A laparoscopic approach may be considered if the hernia defect is large, or if the patient has an increased risk of wound morbidity.

Conclusion
This is the first European and American guideline on the treatment of umbilical and epigastric hernias. It is recommended that symptomatic umbilical and epigastric hernias are repaired by an open approach with a preperitoneal flat mesh.
EHS and AHS guidelines for treatment of primary ventral hernias in rare locations or special circumstances
Authors: Henriksen N A , Kaufmann R , Simons M P , Berrevoet F , East B , Fischer J , Hope W , Klassen D , Lorenz R , Renard Y , Garcia Urena M A , Montgomery A 
Published: January 2020

Abstract

Background
Rare locations of hernias, as well as primary ventral hernias under certain circumstances (cirrhosis, dialysis, rectus diastasis, subsequent pregnancy), might be technically challenging. The aim was to identify situations where the treatment strategy might deviate from routine management.

Methods
The guideline group consisted of surgeons from the European and Americas Hernia Societies. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used in formulating the recommendations. The Scottish Intercollegiate Guidelines Network (SIGN) critical appraisal checklists were used to evaluate the quality of full-text papers. A systematic literature search was performed on 1 May 2018 and updated 1 February 2019. The Appraisal of Guidelines for Research and Evaluation (AGREE) instrument was followed.

Results
Literature was limited in quantity and quality. A majority of the recommendations were graded as weak, based on low quality of evidence. In patients with cirrhosis or on dialysis, a preperitoneal mesh repair is suggested. Subsequent pregnancy is a risk factor for recurrence. Repair should be postponed until after the last pregnancy. For patients with a concomitant rectus diastasis or those with a Spigelian or lumbar hernia, no recommendation could be made for treatment strategy owing to lack of evidence.

Conclusion
This is the first European and American guideline on the treatment of umbilical and epigastric hernias in patients with special conditions, including Spigelian and lumbar hernias. All recommendations were weak owing to a lack of evidence. Further studies are needed on patients with rectus diastasis, Spigelian and lumbar hernias.
OSdlbcl: An online consensus survival analysis web server based on gene expression profiles of diffuse large B‐cell lymphoma
Authors: Dong Huan , Wang Qiang , Zhang Guosen , Li Ning , Yang Mengsi , An Yang , Xie Longxiang , Li Huimin , Zhang Lu , Zhu Wan , Zhao Shuchun , Zhang Haiyu , Guo Xiangqian 
Published: January 2020

AbstractDiffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin lymphoma (NHL) and is a clinical, pathological, and molecular heterogeneous disease with highly variable clinical outcomes. Currently, valid prognostic biomarkers in DLBCL are still lacking. To optimize targeted therapy and improve the prognosis of DLBCL, the performance of proposed biomarkers needs to be evaluated in multiple cohorts, and new biomarkers need to be investigated in large datasets. Here, we developed a consensus Online Survival analysis web server for Diffuse Large B‐Cell Lymphoma, abbreviated OSdlbcl, to assess the prognostic value of individual gene. To build OSdlbcl, we collected 1100 samples with gene expression profiles and clinical follow‐up information from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. In addition, DNA mutation data were also collected from the TCGA database. Overall survival (OS), progression‐free survival (PFS), disease‐specific survival (DSS), disease‐free interval (DFI), and progression‐free interval (PFI) are important endpoints to reflect the survival rate in OSdlbcl. Moreover, clinical features were integrated into OSdlbcl to allow data stratifications according to the user's special needs. By inputting an official gene symbol and selecting desired criteria, the survival analysis results can be graphically presented by the Kaplan‐Meier (KM) plot with hazard ratio (HR) and log‐rank p value. As a proof‐of‐concept demonstration, the prognostic value of 23 previously reported survival associated biomarkers, such as transcription factors FOXP1 and BCL2, was evaluated in OSdlbcl and found to be significantly associated with survival as reported (HR = 1.73, P < .01; HR = 1.47, P = .03, respectively). In conclusion, OSdlbcl is a new web server that integrates public gene expression, gene mutation data, and clinical follow‐up information to provide prognosis evaluations for biomarker development for DLBCL. The OSdlbcl web server is available at https://bioinfo.henu.edu.cn/DLBCL/DLBCLList.jsp.
The Effects of Goal Publicity and Self‐Monitoring on Escalation of Goal Commitment
Authors: Jiao Jinfeng , Cole Catherine A. 
Published: January 2020

AbstractThe current research examines whether the public or private nature of consumer goals affects goal‐commitment escalation following initial goal failure. In particular, the authors explore the moderating role of self‐monitoring. Across three experiments, the authors demonstrate that high self‐monitors are more likely to persist following a public failure than a private failure. However, the public versus private nature of the goal failure does not affect low self‐monitors’ persistence. The authors also explore two boundary conditions for this effect by manipulating the timing of feedback and by testing the role of the perceived value of the incentive for achieving the goal. The article concludes with a discussion of theoretical and managerial insights from this work.
Recurrent severe hypophosphatemia following intravenous iron administration
Authors: Nataatmadja Melissa Stephanie , Francis Ross 
Published: January 2020

Key Clinical MessageHypophosphatemia postintravenous iron is frequent but under‐recognized. If prolonged or recurrent, it can cause osteomalacia. The likely mechanisms are direct toxicity to proximal tubular cells causing phosphate wasting, elevated Fibroblast growth factor‐23 (FGF‐23), and reduced 1,25‐dihydroxyvitamin D (1,25(OH)2D). Hypophosphatemia may be severe and persist for months, necessitating phosphate replacement until normalization of serum levels occurs.
Polyol Synthesis of Ag/BN Nanohybrids and their Catalytic Stability in CO Oxidation Reaction
Authors: Konopatsky Anton S. , Leybo Denis V. , Firestein Konstantin L. , Chepkasov Ilya V. , Popov Zakhar I. , Permyakova Elizaveta S. , Volkov Ilia N. , Kovalskii Andrey M. , Matveev Andrei T. , Shtansky Dmitry V. , Golberg Dmitri V. 
Published: January 2020

AbstractPolyol method provides variety of options for microstructure control of a synthesized material. The present study aims to demonstrate that in case of Ag/h‐BN nanohybrid fabrication the synthesis time requires precise tuning. Nonlinear correlation between synthesis time and Ag nanoparticles (AgNPs) formation and deposition is found and discussed. Catalytic stability of the studied system toward carbon monoxide oxidation is investigated for the first time. Two stages of catalytic activity decrease are found and associated with the sintering of AgNPs of the certain size. Correlations between Ag content, particle size distribution and temperature of complete CO conversion allow us to conclude that AgNPs, which size is below the critical value (3 nm), have a decisive role in Ag/BN nanohybrid catalytic performance. Density functional theory (DFT) calculations uncover the mechanism behind the increased catalytic activity of smaller AgNPs and highlight an importance of the Ag/BN interfacial regions.
Recent Advances in Continuous‐Flow Enantioselective Catalysis
Authors: Yu Tao , Ding Zhengwei , Nie Wenzheng , Jiao Jiao , Zhang Hailong , Zhang Qian , Xue Chao , Duan Xinhua , Yamada Yoichi M. A. , Li Pengfei 
Published: January 2020

AbstractThe increased demand for more efficient, safe, and green production in fine chemical and pharmaceutical industry calls for the development of continuous‐flow manufacturing, and for chiral chemicals in particular, enantioselective catalytic processes. In recent years, this emerging direction has received considerable attention and has seen rapid progress. In most cases, catalytic enantioselective flow processes using homogeneous, heterogeneous, or enzymatic catalysts have shown significant advantages over the conventional batch mode, such as shortened reaction times, lower catalysts loadings, and higher selectivities in addition to the normal merits of non‐enantioselective flow operations. In this Minireview, the advancements, key strategies, methods, and technologies developed the last six years as well as remaining challenges are summarized.
KNiB4O6F3: A Layered Fluorooxoborate with Charge‐Oriented Ordering
Authors: Tao Ce , Li Rukang 
Published: January 2020

AbstractA layered fluorooxoborate, KNiB4O6F3, contains a new (B4O6F4)4− group built of one planar (BO3)3− triangle and three tetrahedral (BO3F)4− units. Those units are joined together by sharing the oxygen atoms to form a 2‐dimensinal (BO3/2F)3BO3/2)∞ layer. K+ and Ni2+ occupy on the sides with F− and O2− of the (BO3/2F)3BO3/2)∞ layer with a high (positive charge) to high (negative charge) and low to low coordination. Such kind of charge‐oriented ordering is found to be governed by the stabilization energy of Coulomb interaction of the cations in certain sites. It is hoped that this mechanism of ordering may provide an additional tool for designing new structures with favourable properties, such as ferroelectrics or nonlinear optical materials.
Efficient Intersystem Crossing in the Tröger's Base Derived From 4‐Amino‐1,8‐naphthalimide and Application as a Potent Photodynamic Therapy Reagent
Authors: Zhao Yingjie , Chen Kepeng , Yildiz Elif Akhuseyin , Li Shujing , Hou Yuqi , Zhang Xue , Wang Zhijia , Zhao Jianzhang , Barbon Antonio , Yaglioglu Halime Gul , Wu Huijian 
Published: January 2020

AbstractIntersystem crossing (ISC) was observed for naphthalimide (NI)‐derived Tröger's base, and the ISC was confirmed to occur by a spin‐orbital charge‐transfer (SOCT) mechanism. Conventional electron donor/acceptor dyads showing SOCT‐ISC have semirigid linkers. In contrast, the linker between the two chromophores in Tröger's base is rigid and torsion is completely inhibited, which is beneficial for efficient SOCT‐ISC. Femtosecond transient absorption (TA) spectra demonstrated charge‐separation and charge‐recombination‐induced ISC processes. Nanosecond TA spectroscopy confirmed the ISC, and the triplet state is long‐lived (46 μs, room temperature). The ISC quantum yield is dependent on solvent polarity (8–41 %). The triplet state was studied by pulsed‐laser‐excited time‐resolved EPR spectroscopy, and both the NI‐localized triplet state and triplet charge‐transfer state were observed, which is in good agreement with the spin‐density analysis. The Tröger's base was confirmed to be a potent photodynamic therapy reagent with HeLa cells (EC50=5.0 nm).
The α,α‐Dihalocarbonyl Building Blocks: An Avenue for New Reaction Development in Organic Synthesis
Authors: Sadhukhan Santu , Santhi Jampani , Baire Beeraiah 
Published: January 2020

AbstractThe α,α‐dihalocarbonyl moiety is a bifunctional system with agem‐dihalocarbon and a carbonyl carbon in 1,2‐fashion. This is one of the privileged scaffolds in medicinal chemistry due to its chemical and metabolic stability and lipophilicity. They have also been found in numerous structurally divergent natural products and most of their fabricated structures have already been in medicinal use. Apart from their important use in medicinal chemistry, the α,α‐dihalocarbonyl groups have been employed as key building blocks for the development of novel synthetic strategies and utilized as intermediates in total synthesis. In addition to the traditional transformations such as oxidations, reductions, and C−C bond formations, recently several new and non‐classical reactions have also been developed. This review provides short description of existing methods for their synthesis and detailed discussion on the efforts for the discovery and development of new reactions by employing α,α‐dihaloketones as synthetic building blocks. We have presented their use as key functional groups for the synthesis of polycyclic systems of medicinal and material importance and natural products.