bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Mobile App Specifically Designed to Facilitate Exercise in Parkinson Disease: Single-Cohort Pilot Study on Feasibility, Safety, and Signal of Efficacy
Authors: Landers Merrill R , Ellis Terry D 
Published: July 2020

Background
Many people with Parkinson disease do not have access to exercise programs that are specifically tailored to their needs and capabilities. This mobile app allows people with Parkinson disease to access Parkinson disease–specific exercises that are individually tailored using in-app demographic questions and performance tests which are fed into an algorithm which in turn produces a video-guided exercise program.

Objective
To test the feasibility, safety, and signal of efficacy of a mobile app that facilitates exercise for people with Parkinson disease.

Methods
A prospective, single-cohort design of people with Parkinson disease who had downloaded the 9zest app for exercise was used for this 12-week pilot study. Participants, who were recruited online, were encouraged to exercise with the full automated app for ≥150 minutes each week. The primary endpoints were feasibility (app usage and usability questions) and safety (adverse events and falls). The primary endpoints for signal of efficacy were a comparison of the in-app baseline and 8-week outcomes on the 30-second Sit-To-Stand (STS) test, Timed Up and Go (TUG) test, and the Parkinson’s Disease Questionnaire 8 (PDQ8).

Results
For feasibility, of the 28 participants that completed the study, 12 participants averaged >150 minutes of app usage per week (3 averaged 120-150, 4 averaged 90-120, and 9 averaged less than 90 minutes). A majority of participants (>74%) felt the exercise was of value (16/19; 9 nonrespondents), provided adequate instruction (14/19; 9 nonrespondents), and was appropriate for level of function (16/19; 9 nonrespondents). For safety, there were no serious adverse events that occurred during the app-guided exercise. There were 4 reports of strain/sprain injuries while using the app among 3 participants, none of which necessitated medical attention. For signal of efficacy, there was improvement for each of the primary endpoints: STS (P=.01), TUG (P<.001), and PDQ8 (P=.01).

Conclusions
Independent, video-guided exercise using a mobile app designed for exercise in Parkinson disease was safe and feasible though there was variability in app usage. Despite this, the results provide evidence for a signal of efficacy as there were improvements in 3 of the 3 outcomes.

Trial Registration
ClinicalTrials.gov NCT03459586; https://clinicaltrials.gov/ct2/show/NCT03459586
The Infection Rate of COVID-19 in Wuhan, China: Combined Analysis of Population Samples
Authors: Qu Hui-Qi , Cheng Zhangkai Jason , Duan Zhifeng , Tian Lifeng , Hakonarson Hakon 
Published: July 2020

Background
The coronavirus disease (COVID-19) pandemic began in Wuhan, China, in December 2019. Wuhan had a much higher mortality rate than the rest of China. However, a large number of asymptomatic infections in Wuhan may have never been diagnosed, contributing to an overestimated mortality rate.

Objective
This study aims to obtain an accurate estimate of infections in Wuhan using internet data.

Methods
In this study, we performed a combined analysis of the infection rate among evacuated foreign citizens to estimate the infection rate in Wuhan in late January and early February.

Results
Based on our analysis, the combined infection rate of the foreign evacuees was 0.013 (95% CI 0.008-0.022). Therefore, we estimate the number of infected people in Wuhan to be 143,000 (range 88,000-242,000), which is significantly higher than previous estimates. Our study indicates that a large number of infections in Wuhan were not diagnosed, which has resulted in an overestimated case fatality rate.

Conclusions
Increased awareness of the original infection rate of Wuhan is critical for proper public health measures at all levels, as well as to eliminate panic caused by overestimated mortality rates that may bias health policy actions by the authorities.
Design and Implementation of the first Generic Archive Storage Service for Research Data in Germany
Authors: Bach Felix , Schembera BjÃ¶rn , Van Wezel Jos 
Published: July 2020

Research data as the true valuable good in science must be saved and subsequently kept findable, accessible and reusable for reasons of proper scientific conduct for a time span of several years. However, managing long-term storage of research data is a burden for institutes and researchers. Because of the sheer size and the required retention time apt storage providers are hard to find.
Aiming to solve this puzzle, the bwDataArchive project started development of a long-term research data archive that is reliable, cost effective and able store multiple petabytes of data. The hardware consists of data storage on magnetic tape, interfaced with disk caches and nodes for data movement and access. On the software side, the High Performance Storage System (HPSS) was chosen for its proven ability to reliably store huge amounts of data. However, the implementation of bwDataArchive is not dependant on HPSS. For authentication the bwDataArchive is integrated into the federated identity management for educational institutions in the State of Baden-WuÌˆrttemberg in Germany.
The archive features data protection by means of a dual copy at two distinct locations on different tape technologies, data accessibility by common storage protocols, data retention assurance for more than ten years, data preservation with checksums, and data management capabilities supported by a flexible directory structure allowing sharing and publication. As of September 2019, the bwDataArchive holds over 9 PB and 90 million files and sees a constant increase in usage and users from many communities.
Data Communities: Empowering Researcher-Driven Data Sharing in the Sciences
Authors: Springer Rebecca , Cooper Danielle 
Published: July 2020

There is a growing perception that science can progress more quickly, more innovatively, and more rigorously when researchers share data with each other. However many scientists are not engaging in data sharing and remain skeptical of its relevance to their work. As organizations and initiatives designed to promote STEM data sharing multiply – within, across, and outside academic institutions – there is a pressing need to decide strategically on the best ways to move forward. In this paper, we propose a new mechanism for conceptualizing and supporting STEM research data sharing.. Successful data sharing happens within data communities, formal or informal groups of scholars who share a certain type of data with each other, regardless of disciplinary boundaries. Drawing on the findings of four large-scale qualitative studies of research practices conducted by Ithaka S+R, as well as the scholarly literature, we identify what constitutes a data community and outline its most important features by studying three success stories, investigating the circumstances under which intensive data sharing is already happening. We contend that stakeholders who wish to promote data sharing – librarians, information technologists, scholarly communications professionals, and research funders, to name a few – should work to identify and empower emergent data communities. These are groups of scholars for whom a relatively straightforward technological intervention, usually the establishment of a data repository, could kickstart the growth of a more active data sharing culture. We conclude by offering recommendations for ways forward.
The Introduction of State Regulation and Auditor Retendering in School Districts: Local Audit Market Structure, Audit Pricing, and Internal Control Reporting
Authors: Elder Randal J. , Yebba Alfred A. 
Published: July 2020

SUMMARY
The impacts of auditor retendering or rotation mandates and auditor selection have been a regulatory concern for some time. However, finding suitable research settings to examine these policies has been a challenge. This paper reports the results of a study (Elder and Yebba 2020) that explores the consequences of implementing a retendering policy in a local governmental audit market. The study finds an association between periodic retendering and auditor concentration, including the growth of fee premium specialization within the market. We also find changes in quality associated with these mandates, including greater auditor effort, evidenced through higher audit fees and longer reporting delays, and improved documentation of internal controls evidenced through increased reporting of control deficiencies. Collectively, we provide evidence that periodic retendering of audit services may provide a suitable level of quality enhancement while not forcing auditees to absorb audit inefficiencies common with a rotation policy.
Daya Saing dan Pertumbuhan Ekonomi Negara Berkembang ASEAN
Authors: Afif Fadeli Yusuf , Ciptawaty Ukhti 
Published: July 2020

The purpose of this study is to look at the condition of the country's competitiveness and its influence on ASEAN economic growth. The data used consists of panel data consisting of time series data for 2009 - 2019 and a cross section of five ASEAN countries with the highest level of competitiveness. The variables used are economic growth, competitiveness, labor participation, and foreign direct investment. The analysis tool used is panel data regression, the Fixed Effect Model (FEM). The results show that competitiveness, labor participation, and foreign direct investment have a positive and significant effect on economic growth in the five developing ASEAN countries.

Keywords: ASEAN, Competitiveness, Economic Growth, and Fixed Effect Model (FEM).
Identifikasi Dampak Sanksi Ekonomi Terhadap Perekonomian Turki
Authors: Kartika Metasari , Sikajudin Irvan 
Published: July 2020

This research aims to identify the economic sanctions obtained by the Turkish state and to know the data behaviour or trends in export data, imports, inflation, exchange rates and GDP before, during and after the provision of economic sanctions on the Turkish state. The study used secondary data from the presidential decree, newspaper, actual news, the official announcement which would later be processed into economic sanctions data, The World Bank, OECD, TÜIK, investing.com that some data was aggregated and processed by FRED. The study used the period before, on and after economic sanctions were granted to the Turkish state. After the data is collected, the analysis is then described in a descriptive and then illustrated through words and graphs, which will later use the techniques of deductive, inductive or mixed (deductive and inductive) and descriptive, that is collecting and compiling the necessary data in this study. The results of this study showed that economic sanctions in Turkey are present in various sectors and have a negative effect on affected sectors when economic sanctions are imposed against Turkey, So that if economic sanctions are not handled appropriately then this can make the Turkish economy continue to decline.
Strategi Pengadaan Bahan Non Buku Di Perpustakaan Universitas Negeri Padang Pada Era Revolusi 4.0
Authors: Aulia Atikah 
Published: July 2020

This study aims to determine the strategy of procurement of non-book material in the central library of the state university of padang that can raise procurement and constraints in implementing strategies in the revolutionary era 4.0. this type of research is a qualitative approach with a method of interviewing the head of the padang state university library and staff management staff, library research by collecting data from reference materials, archives, and documents related to this research. The result of this study are the fact that in the central library of the state university of padang procurement of non-book material is no longer used because of the lack of a place for non-book material media such as tools, so people search for and obtain material or material on the internet that occurred in the revolutionary era 4.0.
Keywords: (strategy, procurement of non-book material, revolutionary era 4.0)
Media Sosial Sebagai Sarana Promosi Karya Musik Di Era Industri 4.0 (Studi Kasus Pada Band Sendau Gurau Di Semarang)
Authors: Muhammad Yus Rizal , Rachman Abdul 
Published: July 2020

Perkembangan dan kemajuan teknologi informasi terus meningkat tiap tahunnya, hal ini membuat jumlah pengguna internet atau media sosial semakin tinggi diseluruh Dunia. Kemunculan teknologi digital tersebut membuka peluang di berbagai bidang industri khususnya industri musik, layanan streaming sekarang sudah menjadi sesuatu yang sangat berpengaruh di era industri 4.0. Penelitian ini bertujuan untuk mengetahui dan mengidentifikasi bagaimana penggunaan media sosial sebagai sarana promosi karya musik band Sendau Gurau di era industri 4.0. Penelitian ini menggunakan metode kualitatif dengan pengumpulan data melalui observasi, wawancara, dokumentasi dan studi pustaka. Hasil penelitian menunjukan bahwa grup band Sendau Gurau melakukan promosi lagunya melalui platform digital YouTube dan media sosial lainnya seperti Instagram, Facebook, Whatsapp yang berkesinambungan sehingga menarik pengguna media sosial untuk menonton hasil karya mereka yang sudah diunggah ke akun YouTube. Dengan strategi promosi tersebut banyak pengguna media sosial yang tertarik menikmati karya musik band Sendau Gurau melalui media sosial maupun live performance.
PENINGKATAN KOMPETENSI IKATAN SARJANA OLAHRAGA INDONESIA MELALUI PENGKAJIAN SPORT DEVELOPMENT INDEX
Authors: Bafirman Bafirman , Badri Hanif Badri 
Published: July 2020

Indonesian Bachelor of Sports association organization, according to its tasks and functions, must think and work on how to improve the sports development index especially in its region and provide recommendations to policy makers to be the basis for developing future sports programs. Sport Development Index (SDI) is one of the instruments to identify the success of sports development significantly from four elements, namely; (1) Community participation in sports, (2) Facilities built for exercising (3) physical fitness, and (4) Human resources. Sports coaching in Tanah Datar District has been carried out through Sports Physical Education and Health, community sports and achievement sports. The development is carried out by involving various related elements, government, community, private sector, etc. synergistically, but with the result. still not encouraging. Seen; the relatively low number of people exercising, the limited sports facilities and infrastructure, etc. With the improvement of ISORI's organizational competence, it is expected that the Sports Flat index of Tanah Datar in the future will increase.
Keywords: Sport; Development; Index; ISORI.
Wybrane parametry agrochemiczne gleb użytków zielonych w Polsce
Authors: LIPIŃSKI WOJCIECH , LIPIŃSKA HALINA , KORNAS RAFAŁ , WATROS ANNA 
Published: July 2020

W 1026 obiektach położonych na glebach organicznych (187) i mineralnych (839) dokonano oceny niektórych parametrów agrochemicznych gleby, w tym pH, zawartości przyswajalnych form P, K i Mg oraz Nmin (N-NH4 i N-NO3). W wodach pobranych na głębokości 90 cm pod powierzchnią gruntu określono ilość fosforu oraz azotu azotanowego. Uzyskane wyniki badań pozwoliły na stwierdzenie, że sposób użytkowania miał związek z wybranymi właściwościami fizykochemicznymi i chemicznymi gleby oraz ze składem chemicznym wód pobranych z głębokości 90 cm pod powierzchnią gruntu. Zaobserwowano również pewne prawidłowości w kształtowaniu parametrów fizykochemicznych i chemicznych gleby przez zwierzęta gospodarskie, wyrażone wskaźnikiem obsady w DJP ∙ ha–1, w tym wpływu na pH oraz zawartość fosforu przyswajalnego. Stwierdzane ilości składników biogennych w wodach nie przekraczały 1,6 mg P ∙ dm–3 w obiektach z glebami organicznymi użytkowanymi pastwiskowo i 8,7 mg N-NO3 w glebach mineralnych o użytkowaniu kośno-pastwiskowym.
Efficacy of sodium iodide for prevention of respiratory disease in preweaned dairy calves
Authors: Gamsjäger Lisa , Vander Ley Brian L. , Knych Heather K. , McArthur Gary R. , Heller Meera C. 
Published: July 2020

Abstract

OBJECTIVE
To determine the pharmacokinetics of sodium iodide (NaI) following oral administration to preweaned dairy calves, and to assess the efficacy of NaI for prevention of bovine respiratory disease (BRD) in preweaned calves at a commercial calf-raising facility.

ANIMALS
434 healthy preweaned dairy calves.

PROCEDURES
In the first of 2 experimental trials, each of 7 calves received NaI (20 mg/kg, PO) once. Blood and nasal fluid samples were collected at predetermined times before (baseline) and for 72 hours after NaI administration for determination of iodine concentrations. Pharmacokinetic parameters were determined by noncompartmental analysis. In the second trial, 427 calves at a calf-raising facility were randomly assigned to receive NaI (20 mg/kg, PO, 2 doses 72 hours apart; n = 211) or serve as untreated controls (216). Health outcomes were compared between the 2 groups.

RESULTS
For all 7 calves in the pharmacokinetic trial, the iodine concentration in both serum and nasal fluid samples was significantly increased from the baseline concentration and exceeded the presumed therapeutic iodine concentration (6.35 μg/mL) throughout the sampling period. In the on-farm trial, the odds of being treated for BRD before weaning for NaI-treated calves were twice those for control calves (OR, 2.04; 95% CI, 1.38 to 3.00).

CONCLUSIONS AND CLINICAL RELEVANCE
Results suggested that, although oral administration of NaI (20 mg/kg) to preweaned dairy calves achieved iodine concentrations presumed to be effective in both serum and nasal fluid, it was not effective for prevention of BRD in preweaned calves at a commercial calf-raising facility.
Homology modeling of actin protein in Leishmania donovani and in silico prediction of active drugs
Authors: Bansal Dimpal Rani , Patil Hanumanthrao Chandershekar , Patil Rajesh Kumari 
Published: July 2020

Objectives:
Leishmaniasis is a disease caused by leishmania parasite which is genus of trypanosome protozoa. Leishmania donovani promastigote inhibits biogenesis of phagolysosome due to the accumulation of periphagosomal F-actin. This inhibition of phagosome maturation gives favorable environment for differentiation of promastigote-to-amastigote and causes disease progression. L. donovani actin (LdACT) has been found to have unconventional biochemical behavior due to the different amino acid region in its sequence suggesting that it must have a three-dimensional (3D) structure different from eukaryotic actins making it a more specific for predication of antileishmanial drugs which is main objective of this study.

Material and Methods:
For carrying out this study, protein sequence was retrieved from the database SWISSPROT, analyzed by BIOEDIT software followed by primary and secondary structure prediction by PROTPARAM and SOPMA. A 3D structure of same was constructed by homology modeling using the yeast actin-human gelsolin segment 1 complex (protein data bank [PDB] ID:1yag) as a template with the help of Swiss model. The final model obtained was further accessed by PROCHECK and VERIFY 3D software which ensured the reliability of the model. This model of actin protein was further used for screening different chemical compounds with high binding affinity by GOLD and DISCOVERY STUDIO.

Results:
The results give information about the some inhibitors having highest binding affinity to the actin protein.

Conclusion:
This study will be useful for the development of pharmacophore models for in silico predication of active drugs as a part of antileishmanial drug therapy.
Bentuk Kebijakan Amerika Serikat Terhadap Ancaman Cyber Crime China Sebagai Bentuk Upaya Proteksianisme Terhadap Keamanan Nasional
Authors: Perwita Sari Lukita 
Published: July 2020

Globalisasi telah mendorong perkembangan terknologi yang semakin tidak terbatas dan membawa perubahan signifikan terhadap keamanan suatu Negara. Perkembangan teknologi ini pula sebenarnya tidak hanya bedampak baik tetapi juga bisa menjadi suatu ancaman tergantung dari cara memanfaatkannya. China sebagai salah satu Negara yang mengalami perkembangan pesat tersebut menggunakan kesempatan ini untuk mencari celah dan mengambil keuntungan dari Negara targetnya yaitu Amerika Serikat. Sejak terjadinya peretasan pada awal tahun 2000an oleh China, Amerika Serikat menggap ini sebagai ancaman untuk keamanan nasionalnya, oleh karena sebagai upaya untuk memproteksi diri dari ancaman cybercrime Amerika Serikat membuat beberapa kebijakan terkait dengan keamanan cybernya. Dalam penelitian ini akan dibahas mengenai konsep keamanan nasional terkait dengan maraknya Cybercrime, dan bentuk bentuk peretasan yang dilakukan oleh China terhadap Amerika Serikat yang nantinya mempengaruhi Amerika Serikat untuk membuat kebijakan di negaranya. Terbukti dari dikeluarkannya beberapa dokumen yang menempatkan cyber security sebagai keamanan utama di Amerika Serikat. Penelitian ini menggunakan metode deskriptif yang menggambarkan keadaan subjek atau objek dalam penelitian yang dapat berupa orang, lembaga, masyarakat dan yang lainnya yang pada saat sekarang berdasarkan fakta-fakta yang tampak atau apa adanya. Serta menggunakan metode kualitatif dengan mengumpulkan data data yang ada sesuai dengan fakta dilapangan .

Kata Kunci : Amerika Serikat, China, Keamanan, Cybercrime, Kebijakan
UNDERSTANDING THE LEGAL ASPECT OF LAW ENFORCEMENT HIRING AND RETENTION
Authors: Neely Jr. Phillip R. , Cillo JD Joseph 
Published: July 2020

Law enforcement agencies struggle to hire officers. Law enforcement agencies are compelled to hold applicants to higher standards. Often, due to the danger that may occur, some applicants feel the pay is not worth the risk. Other applicants cannot complete the series of test such as physical agility, psychological, background checks and their criminal history. Even after an officer is hired, they are held to certain standards they must maintain to remain employed. In the State of Georgia, the Peace Officer Standard Training keeps a record of each officer in Georgia that provides the citizens with qualified, professional, trained, ethical and competent peace officers in law enforcement. Any violations could result in the officer certification being suspended or revoked and will show if a person has been fired or quit voluntarily. Hiring and Retention of law enforcement officers will need to be addressed. Police officers or Deputy Sheriffs are needed to maintain order, investigate crimes whether misdemeanors or felonies and crimes against children or the elderly. If agencies cannot retain officer’s criminals would not have consequences for their actions and society would revert to the days of outlaws and common law citizens. Not being able to hire and retain officers can have an impact externally and internally. If officers are not hired or retain the following could cause long term problems such as; officer burnout due to the overtime, case overloads for investigators or detectives, new recruits using the agency as a steppingstone until another job is found.