bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling university-industry knowledge transfer: insights from bibliographic coupling analysis
Authors: Figueiredo Natália , Patrício Lurdes , Pinheiro Paulo 
Published: February 2025

Purpose
Organizations often utilize external sources to acquire knowledge, and one such area of interest has been the transfer of knowledge between universities and industry (U-I). This topic has gained significant attention in recent years because U-I cooperation brings companies innovation to remain in the market and be competitive. This paper aims to develop and deepens the topic, providing a Bibliometric-Systematic Literature Review (B-SLR) on knowledge transfer (KT), cooperation and U-I, interactions, links and interdependencies of new research streams. This research pretends to summarize the state of the art of the past literature using a rigorous methodological approach.

Design/methodology/approach
A bibliometric analysis was performed using the Web of Science database, specifically employing Bibliographic Coupling analysis.

Findings
The literature systematization enabled the identification of four distinct clusters: (1) Drivers and Motivational Factors, (2) Specificities in the Selection of Knowledge Transfer Channels, (3) Strategic Challenges and (4) Mechanisms and Contexts.

Originality/value
The analysis highlights significant trends and gaps in current research, providing a comprehensive understanding of the field. Based on the literature analyzed, it was possible to outline lines for future investigation, offering valuable insights for academia and industry practitioners to enhance U-I knowledge transfer.
Optimizing planting density and variety allocation synergistically to improve maize yield and resource utilization efficiency in different agroecological zones of southwest China
Authors: Cheng Yi , Wei Pengcheng , Chen Du , Zheng Yingxia , Song Bi 
Published: February 2025

AbstractEffective matching between the heat demand of maize varieties and regional resources is essential for achieving high yields. To evaluate the effects of planting density and variety allocation on maize yield and resource utilization efficiency in the different agroecological zones of southwest China, we conducted experiments in five agroecological zones in Guizhou Province. When comparing the same planting density at different sites, grain yield and dry matter accumulation decreased in the following order: Weining, Bijie > Tongren > Anshun and Xingren. Jinyu 838 and Xingzhongyu 801 had a higher yield (12.91 and 12.86 t ha−1) at 82500 plants ha−1 at Weining. The production efficiency for effective accumulated temperature (g m−2 [°C·day]−1) at Weining was higher than that at the other sites. However, the production efficiency for cumulative solar radiation (g MJ−1) at Weining was lower than that at the Anshun and Tongren sites. Moreover, grain yield and dry matter accumulation were positively correlated with the diurnal temperature range, accumulated solar radiation, and number of growing days. Therefore, by optimizing variety and planting density, maize yield and resource utilization efficiency can be improved in areas with large diurnal temperature and high accumulated solar radiation in southwest China.
Pump‐Induced Hemolysis of Speed Modulated Axial‐Flow Left Ventricular Assist Devices
Authors: Borchers Patrick , Österlein Kück Ailín , Leonhardt Steffen , Walter Marian 
Published: February 2025

ABSTRACTBackgroundReduced arterial pulsatility during continuous‐flow left ventricular assist device (LVAD) support is associated with certain adverse events. An approach to increase arterial pulsatility is pump speed modulation. Therefore, this in vitro study compares the pump‐induced hemolysis of constant speed and modulated speed modes for two different axial‐flow LVADs. Furthermore, the hemolytic performance of both LVADs is compared.MethodsTwo Sputnik1 and two HeartMate2 (HM2) axial‐flow LVADs were operated simultaneously for 6 h in automated hemolysis test benches (n = 7 for each mode). Rectangular speed patterns with modulation rates of 70 and 140 bpm were investigated. Speed modulation amplitudes provided head pressures between 80 and 120 mmHg. To quantify hemolysis, plasma‐free hemoglobin was determined every hour and the modified index of hemolysis (MIH) was calculated.ResultsSpeed modulation increased all MIH values of the Sputnik1 LVADs, but decreased most MIH values of the HM2 LVADs compared to the constant speed mode. However, significant differences were only observed for one Sputnik1. Furthermore, the Sputnik1 pumps induced lower MIH levels compared to the HM2 pumps using constant speed mode.ConclusionsIt seems that the HM2 can be operated in speed modulation mode without an increased risk of hemolysis. However, for the Sputnik1, the potential benefits of speed modulation must be balanced against the risk of increased hemolysis. The underlying causes need to be investigated in future studies using computational fluid dynamics. Furthermore, using the clinically established constant speed mode, it appears that the Sputnik1 will cause fewer hemolytic issues than the HM2.
Relevance of ecological momentary assessment for medication adherence in clinical settings: A precision psychiatry approach
Authors: Chirokoff Valentine , Tessier Arnaud , Serre Fuschia , Dupuy Maud , Auriacombe Marc , Chanraud Sandra , Berthoz Sylvie , Fatseas Melina , Misdrahi David 
Published: February 2025

AbstractBackgroundMedication non‐adherence is a leading cause of treatment failure in psychiatric populations. However, current studies highlight the lack of methodological guidance on medication assessments. Ecological Momentary Assessment (EMA), using smartphone‐based evaluations, shows promise for real‐time monitoring in everyday settings.AimsThis study evaluated EMA's effectiveness in assessing medication adherence in patients with schizophrenia, depression, and substance use disorders (SUD), covering various treatment regimens.Materials & MethodsA total of 133 participants (27 with schizophrenia, 20 with depression, 44 with SUDs, and 42 healthy controls) completed EMA via study‐provided smartphones five times daily over 1 week. Treatment regimens, categorized by mono vs. polytherapy and single vs. multiple daily doses, were documented. EMA adherence was calculated from the completion rate of the assessments, while medication adherence was assessed daily for patients. Both mean medication adherence and adherence variation over time were analysed by diagnosis and treatment regimen.ResultsAll groups demonstrated high mean EMA and medication adherence, with minor variations across treatment types. Importantly, patients showed improved adherence over time, independently of diagnosis or regimen.DiscussionThese findings indicate EMA's potential as an effective method for capturing medication adherence in psychiatric populations.ConclusionThe approach's capacity for real‐time, context‐sensitive data collection could reveal adherence patterns and changes not detectable by conventional methods, offering valuable insights for clinical practice.
Sex differences in the vasoactive effect of transient receptor potential channels: TRPM3 as a new therapeutic target for (neuro)vascular disorders
Authors: Rivera‐Mancilla Eduardo , Musterd‐Bhaggoe Usha M. , Schutter Dennis , van den Bogaerdt Antoon , Vincent Arnaud J. P. E. , Villalón Carlos M. , Danser Alexander H. J. , MaassenVanDenBrink Antoinette 
Published: February 2025

AbstractBackground and PurposeSex‐dependent vascular effects of transient receptor potential (TRP) channels and sex dimorphism in migraine are not yet fully characterized. We investigated the differential vasoactive effects of TRP ankyrin 1 (TRPA1), TRP melastatin 3 (TRPM3) and TRP vanilloid 1 (TRPV1) channels, their pharmacological mechanism(s), and localization and expression in human isolated blood vessels.Experimental ApproachAgonist responses to cinnamaldehyde (TRPA1), pregnenolone sulfate (PregS, TRPM3) or capsaicin (TRPV1) were analysed using wire myography in segments of human coronary (HCAs) and middle meningeal (HMMAs) arteries from men and women. The mechanisms involved in these responses were investigated using the antagonists/blockers/inhibitors: HC‐030031 (TRPA1), isosakuranetin (TRPM3), capsazepine (TRPV1), olcegepant (calcitonin gene‐related peptide [CGRP] receptor), L‐NAME (nitric oxide synthase [NOS]), indomethacin (cyclooxygenase [COX]), TRAM‐34 + apamin (K+ channels) or MK‐801 (N‐methyl‐d‐aspartate [NMDA] receptor). Fluorescence microscopy, quantitative polymerase chain reaction (qPCR), and western blotting were performed to investigate their location and expression, respectively.Key ResultsIn HCAs and HMMAs, (i) capsaicin‐induced relaxation remained unchanged after the above‐mentioned antagonists/blockers/inhibitors and (ii) cinnamaldehyde‐induced relaxation was blocked by olcegepant. PregS‐induced maximal relaxation was significantly enhanced in isolated arteries from females compared with males and was inhibited after isosakuranetin, MK‐801 or L‐NAME. TRPM3 mRNA and protein expression, along with NMDA protein levels, were higher in arteries from females than males.Conclusion and ImplicationsModulation of vascular tone in HCAs and HMMAs by activation of TRPM3 is sex‐dependent, likely involving NMDA receptors. This represents a new therapeutic direction, targeting sex dimorphism in migraine and its related cardiovascular events.
Characterisation of SLC38A8 and Its Role in Retinal Pathways and Disease
Authors: Weiner Chen , Hecht Idan , Lindovsky Jiri , Palkova Marcela , Krupkova Michaela , Kasparek Petr , Prochazka Jan , Sedlacek Radislav , Kotlyar Alina , Raini Nir , Zehavi Yonathan , Yegorov Yevgeni , Hilman Pnina , Basel Ranin , Abu‐Hamed Ramzia , Shomron Noam , Pras Eran 
Published: February 2025

ABSTRACTBackgroundThis study investigates the role of the SLC38A8 gene. SLC38A8 facilitates glutamine influx, which converts to glutamate in the visual pathway. Mutations in SLC38A8 are associated with FHONDA syndrome, a subtype of foveal hypoplasia with congenital nystagmus and optic‐nerve‐decussation defects without pigmentation leading to severe vision loss.MethodsIn vivo and in vitro methods were conducted using retinal cell lines overexpressing SLC38A8, and Slc38a8/Slc38a7 gene‐edited mice to evaluate visual function and physiological changes. Statistical analyses included two‐way ANOVA, multiple regression, and ANCOVA.ResultsIn vitro, SLC38A8 overexpression influenced retinal gene expression, light detection, and visual perception, as well as glutamine and glutamate dynamics. In Y79SNAT8‐OE cells, glutamate levels were significantly higher under light conditions compared to dark conditions at 12 h (3.4 ± 0.16 nmol/μl vs. 3.9 ± 0.17 nmol/μl, p = 0.0011) and 17 h (3.6 ± 0.22 nmol/μl vs. 4.5 ± 0.24 nmol/μl, p = 0.0001), a pattern not observed in control cells. SLC38A8 expression also increased significantly (RQ = 2.1 ± 0.11, p < 0.05) in Y79 cells under glutamine deprivation. In vivo, Slc38a8‐truncated gene mice exhibited altered testicular morphology, with significantly reduced volume (70.9 ± 5.1 mm3 vs. 85.5 ± 6.7 mm3, p = 0.023), and reduced length (4.8 ± 0.2 mm vs. 5.4 ± 0.4 mm, p = 0.0169), alongside degenerative changes in germinal epithelium, and elevated liver enzyme. Despite normal eye morphology, retinal thickness, and visual evoked potentials, electroretinogram and behavioural tests indicated enhanced scotopic responsiveness with significant increases in a‐wave (162.98 ± 14.1 μv vs. 133.9 ± 36.9 μv, p = 1.5e‐07) and b‐wave amplitudes (274.82 ± 25.2 μv vs. 199.9 ± 56.1 μv, p = 3.02e‐09).ConclusionsOur findings underscore SLC38A8 role in retinal function and glutamine‐glutamate metabolism, with clinical implications for FHONDA and potential future dietary intervention targeting glutamine or glutamate.
Prioritising people who use drugs in health policy: An Australian Capital Territory case study
Authors: Bowles Devin , Yar Elisabeth , van der Sterren Anke 
Published: February 2025

AbstractIntroductionGovernments are increasingly identifying priority populations on which to focus health policy and to measure health and wellbeing outcomes. Prioritising populations that are considered to be higher risk or to have particular needs that may not be captured within the parameters of health policy developed for the general population, is essential to health equity and efficient resource allocation. However, the criteria that governments use for prioritising populations is often vague or unspecified. To date, people who use drugs are almost never identified as a priority population in health policy, despite poor health and wellbeing outcomes.MethodsWe developed three‐pronged criteria—disadvantage, prevalence/accessibility and amenability to change—for prioritising populations in government health policy. We used these criteria to compare people who access alcohol, tobacco and other drug (ATOD) services with populations which are prioritised within the Australian Capital Territory Government's Wellbeing Framework.ResultsUse of the criteria indicates that health policy prioritisation of people who access ATOD services is warranted. People who access ATOD services experienced worse health and wellbeing outcomes across all measures.Discussion and ConclusionsGiven increasingly explicit prioritisation of populations in health policy, there is an opportunity to advance health equity and embed policy efficiency through formal and transparent consideration of which populations to prioritise. Using set criteria for prioritising populations in health policy is possible, and could help identify populations often overlooked for prioritisation, such as people who access ATOD services.
Integrative bioinformatic analysis of prognostic biomarkers in heart failure: Insights from clinical trials
Authors: Bastos José Mesquita , Scala Noemi , Perpétuo Luís , Mele Bruno Hay , Vitorino Rui 
Published: February 2025

AbstractBackgroundHeart failure (HF) remains a major cause of morbidity and mortality worldwide. Therefore, there is a need to identify robust biomarkers to improve early diagnosis, stratify disease severity and predict outcomes. Biomarkers such as galectin‐3 (Gal‐3), TIMP‐1, BNP, NT‐proBNP, CysC, CA125, ST2 and MMP9 have shown the potential to reflect the pathophysiology of HF. Despite their clinical potential, their integration into routine practice is still limited. The use of bioinformatics may help uncover critical associations between these biomarkers and the progression of HF, providing opportunities for personalized disease management.MethodsFollowing PRISMA guidelines, a systematic review of clinical studies was performed using databases with time constraints. The major proteins associated with HF were identified and their diagnostic and prognostic roles were analysed.ResultsThe study emphasizes that galectin‐3 (Gal‐3) and TIMP‐1 serve as key indicators of fibrosis and inflammation, while BNP and NT‐proBNP are reliable markers of cardiac stress. Cystatin C (CysC) reflects renal dysfunction, and CA125 correlates strongly with venous congestion. In addition, ST2 and MMP9 provide valuable insights into inflammation and tissue remodelling processes. These biomarkers are consistently elevated in patients with HF, emphasizing their critical role in detecting the systemic and cardiac manifestations of the disease.ConclusionOur results emphasize the importance of including biomarkers such as Gal‐3, TIMP‐1, BNP, NT‐proBNP, CysC, CA125, ST2 and MMP9 in the diagnosis and treatment of HF. Their upregulation reflects the complex pathophysiological processes of HF and supports their use in the clinical setting to improve diagnostic accuracy, prognostic precision and personalized therapeutic strategies.
Posture‐Dependent Modulation of Interoceptive Processing in Young Male Participants: A Heartbeat‐Evoked Potential Study
Authors: Dohata Mayu , Kaneko Naotsugu , Takahashi Ryogo , Suzuki Yuya , Nakazawa Kimitaka 
Published: February 2025

ABSTRACTInteroception, the internal perception of bodily states such as heartbeat and hunger, plays a crucial role in shaping cognitive and emotional states. Since postural control affects cognitive and emotional processing, exploring postural effects on interoception could help uncover the neural mechanisms underlying its effects on cognition and emotion. In this study, we aimed to investigate how different postures affect interoception by using heartbeat‐evoked potentials (HEPs), which reflect the cortical processing of cardiac signals. Two experiments were conducted; Experiment 1 involved 47 healthy male participants comparing sitting and standing postures, and Experiment 2 involved 24 healthy male participants comparing stable and unstable standing conditions. HEPs were analyzed using cluster‐based permutation analysis to identify statistically significant spatiotemporal clusters. In Experiment 1, significant clusters were identified over central electrodes (Cz, C1, C2, FCz, and FC1) within the post‐R‐wave interval of 304–572 ms, revealing significantly lower HEP amplitudes during standing compared to sitting [W = 80, p < 0.001, r = 0.62]. In Experiment 2, HEP amplitudes were significantly lower during unstable standing compared to stable standing [t(20) = 2.9, p = 0.0099, d = 0.62]. Furthermore, we found no significant correlations between HEP changes and physiological changes such as cardiac activity and periodic and aperiodic brain activity. These findings suggest postural differences modulate interoceptive processing, with standing postures attenuating HEP amplitudes, probably because of a redistribution of attentional resources from interoceptive to somatosensory (proprioceptive) and vestibular processing, necessary for maintaining standing posture. This study provides insights into the neural mechanisms underlying posture–interoception interaction.
Hydromethylthionine sustains truncated tau‐dependent inflammation‐lowering effects in mouse brain
Authors: Santos Renato X. , Lee Sophie H. , Lofthouse Richard , Melis Valeria , Robinson Lianne , Leith Michael , Dreesen Eline , Armstrong Paul , Vorley Thomas , Goatman Elizabeth A. , Hull Claire , Riedel Gernot , Wischik Claude M. , Harrington Charles R. 
Published: February 2025

Tauopathies are a heterogeneous mixture of neurodegenerative disorders, including Alzheimer's disease and frontotemporal dementia (FTD), characterised by the accumulation of tau filaments in brain tissue. Tau protein aggregation is inhibited by hydromethylthionine (HMT), an effect that appeared to be prevented in clinical trials for subjects already receiving acetylcholinesterase inhibitors or memantine. Since neuroinflammatory responses are associated with tauopathies, we investigated the effect of HMT on the brain immune response and inflammatory status in line 66 (L66) mice, an FTD‐like model overexpressing human tau, in the presence of memantine. We determined whether HMT (5 and 15 mg·kg−1), either singly or combined with memantine (20 mg·kg−1), would have a sustained impact on neuroinflammation following the cessation of drug administration. The levels of core tau fragments in L66+/− mice (P301S/G335D‐hTau) were decreased in a dose‐dependent manner 12 weeks after the last administration of HMT, an effect that was not affected by memantine. HMT lowered the levels of tumour necrosis factor alpha (TNF‐α), thus favouring an environment conducive to neuronal protection and repair. HMT sustained increased microglial reactivity after its discontinuation, which may assist in the removal of tau aggregates, but co‐administration with memantine prevented the HMT‐sustained activation of microglia. These findings indicate that HMT has a beneficial effect in reducing neuroinflammation that accompanies a decrease in the accumulation of truncated tau species and that these benefits are not susceptible to interference by memantine. In turn, the nature of drug interference between HMT and memantine seems to be independent of tau and related to microglia reactivity.
A Novel 5‐Probe FISH Strategy is Better Equipped for a More Comprehensive and Cost‐Effective Risk Stratification of BCP‐ALL
Authors: Singh Manish K. , Nair Arun S. , Pandey Akshita , Sharma Vineet , Rahman Khaliqur , Gupta Ruchi , Chandra Dinesh , Yadav Sanjeev , Kashyap Rajesh , Arun S. R. , Parihar Mayur 
Published: February 2025

ABSTRACTObjectiveThe modern treatment protocols in B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL) are based on the disease's genetic characteristics and response to treatment. We propose a novel five‐probe FISH strategy to risk stratify the BCP‐ALL and compare its ability with the triple trisomy probe strategy to detect high hyperdiploidy.MethodsAll newly diagnosed BCP‐ALL cases were investigated using a five‐probe FISH panel that included probes targeting BCR::ABL1 fusion, ETV6::RUNX1 fusion, and break‐apart probes for KMT2A, IgH, and CRLF2 rearrangements. Further, a selected number of cases were screened by the triple trisomy probe of 4p11/CEN10/17 (Zytovision, Bremerhaven, Germany) to identify aneuploidy.ResultsOf the 380 patients of BCP‐ALL screened (≤ 18 years: 57.9%; > 18 years: 42.1%) using this five‐probe strategy, we could assign clinically relevant eight risk groups to almost two‐thirds of the patients (similar to the available literature). Compared with the widely accepted triple trisomy probe strategy, we found concordant findings in 75.5% of the patients; the triple trisomy probe could not identify high hyperdiploidy in 24.5% of patients. We observed the presence of (non‐CRLF2) IgH rearrangement in 5.3% of patients.ConclusionsWe conclude that the proposed five‐probe FISH strategy is better equipped to more comprehensively risk stratify BCP‐ALL patients, with an increased ability to identify high hyperdiploidy and a subset of Ph‐like‐BCP‐ALL.
Attitudes Toward Cybervetting in Germany: Impact on Organizational Attractiveness Depends on Social Media Platform
Authors: Schäpers Philipp , Mönke Franz W. , Frieler Chiara‐Maria , Roulin Nicolas , Basch Johannes 
Published: February 2025

ABSTRACTCybervetting, assessing social media in personnel selection, is widely used. However, individuals concerned often perceive this practice negatively. We propose that attitudes toward cybervetting may depend on the platform used and the cultural context. Thus, we transfer the attitudes toward cybervetting scale to a context with strict data regulations: Germany. In an online between‐subjects experiment with platform users and non‐users (N = 100 working professionals and students), we examined attitudes toward cybervetting on different social media platforms (professional: LinkedIn vs. personal: Instagram) and their relationship with organizational attractiveness. We found that German participants viewed cybervetting on professional platforms with more skepticism than American participants. Hierarchical regression analysis revealed higher perceived fairness, lower invasion of privacy, and higher organizational attractiveness when cybervetting was done on professional platforms.
Latin America's Nonlinear Monetary Response to Pandemic Inflation
Authors: Guerra Rafael , Kamin Steven B. , Kearns John , Upper Christian , Vakil Aatman 
Published: February 2025

ABSTRACTThis paper estimates empirical Taylor rules to analyze the recent monetary policy of the five main Latin American inflation‐targeting central banks. We find that during the inflationary surge of 2021–2023, monetary policy reacted more strongly and more quickly to changes in inflation than predicted by a standard linear Taylor rule, estimated on data from the prepandemic period. Although this appears to represent a shift in the monetary reaction function, we think it more likely that Latin American central banks have been following a nonlinear strategy, responding more aggressively to inflation, the higher it rose. We confirmed this by adding the square of inflation to the Taylor rule model: its coefficient was positive and significant, indicating that policy interest rates exhibited a nonlinear response to inflation, even during the prepandemic period, and the model did a better job of predicting the sharp rise in interest rates during 2021–2023.