bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automatic migraine classification using artificial neural networks
Authors: Sanchez-Sanchez Paola A. , García-González José Rafael , Rúa Ascar Juan Manuel 
Published: July 2020

Background: Previous studies of migraine classification have focused on the analysis of brain waves, leading to the development of complex tests that are not accessible to the majority of the population. In the early stages of this pathology, patients tend to go to the emergency services or outpatient department, where timely identification largely depends on the expertise of the physician and continuous monitoring of the patient. However, owing to the lack of time to make a proper diagnosis or the inexperience of the physician, migraines are often misdiagnosed either because they are wrongly classified or because the disease severity is underestimated or disparaged. Both cases can lead to inappropriate, unnecessary, or imprecise therapies, which can result in damage to patients’ health. Methods: This study focuses on designing and testing an early classification system capable of distinguishing between seven types of migraines based on the patient’s symptoms. The methodology proposed comprises four steps: data collection based on symptoms and diagnosis by the treating physician, selection of the most relevant variables, use of artificial neural network models for automatic classification, and selection of the best model based on the accuracy and precision of the diagnosis. Results: The artificial neural network models used provide an excellent classification performance, with accuracy and precision levels >97% and which exceed the classifications made using other model, such as logistic regression, support vector machines, nearest neighbor, and decision trees. Conclusions: The implementation of migraine classification through artificial neural networks is a powerful tool that reduces the time to obtain accurate, reliable, and timely clinical diagnoses.
Pojęcie współmałżonka w prawie unijnym – uwagi na tle orzeczenia w sprawie Coman (C‑673/16)
Authors: Kamarad Ewa 
Published: July 2020

The Term ‘Spouse’ in EU Law – Comments on the Judgment in the Coman Case (C‑ 673‑16)
The paper concerns the judgment of 5 June 2018 issued by the Court of Justice of the European Union in the Coman case (C‑673‑16), in which the Court for the first time defined the term ‘spouse’ for the purpose of Directive 2004/38 on the right of citizens of the Union and their family members to move and reside freely within the territory of the Member States. It discusses the consequences of the judgement and its relation to the traditional mechanisms of private international law and the EU principle of mutual recognition.
Unia Europejska wobec Bałkanów Zachodnich w kontekście kryzysu migracyjnego w latach 2015‑2019
Authors: Banach Wawrzyniec 
Published: July 2020

European Union towards Western Balkans in the Context of Migration Crisis 2015‑2019
The aim of the article is to analyse the actions taken by the European Union towards the Western Balkans in the context of the migration crisis. The study assumes that the migration crisis was an important factor accelerating the accession process of the Western Balkan countries to the European Union. In order to fulfil the research goal, an analysis of sources (European Union documents) was conducted. The paper uses elements of the theory of the regional security complex as a theoretical framework. Firstly, the activities of the European Union before the migration crisis are discussed. Next, the paper focuses on presenting the course of the crisis on the Western Balkan route. The further part of the study discusses the actions taken by the EU towards the countries of the Western Balkans in response to the migration crisis.
Uniform modular lattices and affine buildings
Authors: Hirai Hiroshi 
Published: July 2020

Abstract
A simple lattice-theoretic characterization for affine buildings of type A is obtained. We introduce a class of modular lattices, called uniform modular lattices, and show that uniform modular lattices and affine buildings of type A constitute the same object. This is an affine counterpart of the well-known equivalence between projective geometries (≃ complemented modular lattices) and spherical buildings of type A.
Concentration behavior of semiclassical solutions for Hamiltonian elliptic system
Authors: Zhang Jian , Chen Jianhua , Li Quanqing , Zhang Wen 
Published: July 2020

AbstractIn this paper, we study the following nonlinear Hamiltonian elliptic system with gradient term−ϵ2Δψ+ϵb→⋅∇ψ+ψ+V(x)φ=f(|η|)φ  in RN,−ϵ2Δφ−ϵb→⋅∇φ+φ+V(x)ψ=f(|η|)ψ  in RN,$$\begin{array}{} \displaystyle \left\{ \begin{array}{ll} -\epsilon^{2}{\it\Delta} \psi +\epsilon \vec{b}\cdot \nabla \psi +\psi+V(x)\varphi=f(|\eta|)\varphi~~\hbox{in}~\mathbb{R}^{N},\\ -\epsilon^{2}{\it\Delta} \varphi -\epsilon \vec{b}\cdot \nabla \varphi +\varphi+V(x)\psi=f(|\eta|)\psi~~\hbox{in}~\mathbb{R}^{N},\\ \end{array} \right. \end{array}$$whereη= (ψ,φ) : ℝN→ ℝ2,ϵis a small positive parameter andb⃗is a constant vector. We require that the potentialVonly satisfies certain local condition. Combining this with other suitable assumptions onf, we construct a family of semiclassical solutions. Moreover, the concentration phenomena around local minimum ofV, convergence and exponential decay of semiclassical solutions are also explored. In the proofs we apply penalization method, linking argument and some analytical techniques since the local property of the potential and the strongly indefinite character of the energy functional.
Microbiome of abandoned agricultural and mature tundra soils in southern Yamal region, Russian Arctic
Authors: Abakumov Evgeny , Zverev Aleksei , Morgun Eugenia , Alekseev Ivan 
Published: July 2020

AbstractSoil microbiome plays a significant role in the development of the soil profile and the implementation of key soil biochemical processes. Observed Arctic warming creates significant environmental risks, since permafrost soils contain a huge amount of organic matter, which is in potential risk to be released in the form of greenhouse gases. This work is aimed to investigate the microbiomes in soils of mature tundra and anthropogenically affected areas of the Yamal region using a high-throughput sequencing approach. The taxonomic analysis of the soil microbiomes revealed 33 bacterial and archaeal phyla, among which the dominant wereProteobacteria,Acidobacteria,Actinobacteria,Bacteroides,Chloroflexi,Cyanobacteria,Firmicutes,Gematimonadetes,Patescibacteria,Plantomycetes,Thaumarchaeota,Verrucomicrobia, andWPS-2. The analysis of alpha and beta diversities revealed that undisturbed soil is completely different from anthropogenically affected ones in terms of microorganism biodiversity. Soils of the urban zone of Salekhard were found to be different with regard to the number of operational taxonomic units and beta diversity. Herein the microbiome in the upper and lower layers of soil developed under strong technogenic influence (M19) was unequal both in quality and in quantity. At the same time, soils developed in the recreational zone of Salekhard showed less differentiation profile of microbiome (former crop field and former vegetable garden soils). Microbial communities in the mature tundra soil showed less differentiated microbiome composition.
Safety profile of the transcription factor EB (TFEB)-based gene therapy through intracranial injection in mice
Authors: Li Zhenyu , Ding Guangqian , Wang Yudi , Zheng Zelong , Lv Jianping 
Published: July 2020

Abstract
Transcription factor EB (TFEB)-based gene therapy is a promising therapeutic strategy in treating neurodegenerative diseases by promoting autophagy/lysosome-mediated degradation and clearance of misfolded proteins that contribute to the pathogenesis of these diseases. However, recent findings have shown that TFEB has proinflammatory properties, raising the safety concerns about its clinical application. To investigate whether TFEB induces significant inflammatory responses in the brain, male C57BL/6 mice were injected with phosphate-buffered saline (PBS), adeno-associated virus serotype 8 (AAV8) vectors overexpressing mouse TFEB (pAAV8-CMV-mTFEB), or AAV8 vectors expressing green fluorescent proteins (GFPs) in the barrel cortex. The brain tissue samples were collected at 2 months after injection. Western blotting and immunofluorescence staining showed that mTFEB protein levels were significantly increased in the brain tissue samples of mice injected with mTFEB-overexpressing vectors compared with those injected with PBS or GFP-overexpressing vectors. pAAV8-CMV-mTFEB injection resulted in significant elevations in the mRNA and protein levels of lysosomal biogenesis indicators in the brain tissue samples. No significant changes were observed in the expressions of GFAP, Iba1, and proinflammation mediators in the pAAV8-CMV-mTFEB-injected brain compared with those in the control groups. Collectively, our results suggest that AAV8 successfully mediates mTFEB overexpression in the mouse brain without inducing apparent local inflammation, supporting the safety of TFEB-based gene therapy in treating neurodegenerative diseases.
The dangers of conflating responsible and responsive artefact stewardship with illicit and illegal collecting
Authors: Thomas Suzie , Pitblado Bonnie L. 
Published: July 2020

AbstractArchaeology and private artefact collecting have complex and inextricably linked histories. Archaeologists have long drawn attention to criminal activity among collectors, but to assume that all private owners of cultural material—and any archaeologists who interact with them—have ill-intent or engage in illegal behaviour can cause as much harm to the archaeological record as the criminal actions themselves.
The Effects of a Ketogenic Diet on Sensorimotor Function in a Thoracolumbar Mouse Spinal Cord Injury Model
Authors: Mayr Kyle A. , Kwok Charlie H.T. , Eaton Shane E.A. , Baker Glen B. , Whelan Patrick J. 
Published: July 2020

AbstractSpinal cord injury and peripheral nerve injuries are traumatic events that greatly impact quality of life. One factor that is being explored throughout patient care is the idea of diet and the role it has on patient outcomes. But the effects of diet following neurotrauma need to be carefully explored in animal models to ensure that they have beneficial effects. The ketogenic diet provides sufficient daily caloric requirements while being potentially neuroprotective and analgesic. In this study, animals were fed a high-fat, low-carbohydrate diet that led to a high concentration of blood ketone that was sustained for as long as the animals were on the diet. Mice fed a ketogenic diet had significantly lower levels of tyrosine and tryptophan, but the levels of other monoamines within the spinal cord remained similar to those of control mice. Mice were fed a standard or ketogenic diet for 7 d before and 28 d following the injury. Our results show that mice hemisected over the T10–T11 vertebrae showed no beneficial effects of being on a ketogenic diet over a 28 d recovery period. Similarly, ligation of the common peroneal and tibial nerve showed no differences between mice fed normal or ketogenic diets. Tests included von Frey, open field, and ladder-rung crossing. We add to existing literature showing protective effects of the ketogenic diet in forelimb injuries by focusing on neurotrauma in the hindlimbs. The results suggest that ketogenic diets need to be assessed based on the type and location of neurotrauma.
C. Sánchez Ortiz y A. Sanz Tejeda (coords.): La voz de la memoria, nuevas aproximaciones al estudio de la Literatura Popular de Tradición Infantil, Cuenca, Ediciones de la Universidad de Castilla-La Mancha, 2019
Authors: Torrecilla Ortí María del Carmen 
Published: July 2020

Reseña del libro La voz de la memoria
A Patient With Organic Hypermenorrhea Who Developed Massive Genital Hemorrhage During Treatment Of Acute-Phase Cerebral Infarction And Responded To Microwave Endometrial Ablation
Authors: Kakinuma TOSHIYUKI , Taniguchi Miki , Kakinuma Kaoru , Sakamoto Yuka , Matsuda Yoshio , Ohwada Michitaka 
Published: July 2020

Microwave endometrial ablation (MEA) has been attracting attention as a low-invasive treatment alternative to conventional total hysterectomy for systemic disease-induced hypermenorrhea, such as functional hypermenorrhea and blood coagulation abnormality, and organic disease-induced hypermenorrhea such as myoma of the uterus and adenomyosis. We report a patient with hypermenorrhea causing massive genital hemorrhage during anticoagulant therapy who demonstrated a complete response to MEA.
The patient was 41 years old, gravida 3 para 1. Aphasia and articulation disorder developed during work and she visited the emergency department. Cerebral infarction was noted on head MRI and anticoagulant therapy was initiated. Hypermenorrhea had been observed from approximately 4 years prior, but she had not visited a gynecology department. As massive genital hemorrhage and progression of anemia (Hb: 4.6 g/dL) were observed during the menstrual period, she was referred to our department. Multiple myomas of the uterus were observed on ultrasonography and pelvic MRI, and the patient was diagnosed with organic hypermenorrhea. As there was acute-phase cerebral infarction, MEA was performed as treatment for hypermenorrhea. The postoperative course was smooth and menstruation resumed on postoperative day 21. On subjective evaluation using the visual analogue scale (VAS), both hypermenorrhea and dysmenorrhea markedly improved from 10 to 1. The course was smooth without complications and the postoperative course was also favorable.
MEA is a low-invasive treatment method safely applicable within a short time, and it may be an effective hypermenorrhea treatment method during oral anticoagulant administration or for those with perioperative risk due to complications.
Holocardius amorphus
Authors: Riaño Gamboa Germán 
Published: July 2020

Dentro de la variedad de monstruos ligados al embarazo gemelar, y conocidos con el nombre de Acardius, se encuentra el denominado Hoioacardius Amorphus, que Schatz define como una masa completamente amorfo, sin ninguna apariencia humana y sin rudimentos de corazón.
El onfalocele en nuestro medio
Authors: Milanés P. Jorge , Zabaleta L. Alberto 
Published: July 2020

Presentamos 6 casos de onfalocele ocurridos en recién nacidos de sexo masculino y tratados quirurgicamente mediante la extirpación total de la bolsa herniaria dentro de las 3 primeras horas de vida en 5 casos. En todos ha habido buenos resultados hasta el presente. Se hizo en los 6 casos apendicectomía.
El urocitograma en el embarazo normal y patológico
Authors: Lencioni Leo J. , Martínez Amézaga Luis A. , Lo Blanco Víctor S. , Oberti de Viale María R. , Alonso Claudio 
Published: July 2020

Desde el año 1954, en que tuvimos ocasión de señalar por primera vez en la literatura (35) la importancia del urocitograma como método de exploración de la función endocrina placentaria, se han publicado numerosos trabajos sobre este tema.
Hiperplasia de endometrio. Correlación clínico-patológica. Revisión de casos operados
Authors: Bedoya Hevia Mariano 
Published: July 2020

Siendo el endometrio hiperplásico (H. E.) una de Jas causas más frecuentes de hemorragias uterinas funcion ales (H . U. F.), hemos realizado un estudio particular de esta entidad, en nuestros casos operados, tratando de buscar alguna correlación clínico-patológica.
Tears in rain
Authors: Correia Isabel Maria Sabino 
Published: July 2020

O convite para expor numa cidade na periferia de Lisboa suscita um projeto artístico sobre um local determinado: um cinema em ruínas chamado Lido. Dos factos ao potencial semântico, gera-se um paradigma conceptual para um conjunto de pinturas anteriores e recentes e uma série de colagens novas. Este texto é sobre esse projeto em mediação com o local. É, também, sobre a coexistência, em pintura contemporânea, de uma dupla dinâmica entre a energia vital e a pulsão melancólica. Quando é o próprio olhar que gera a obra, a questão essencial centra-se na relação com a realidade, o que do mundo persiste nela e como se lida com tudo isso. Este é, pois, um caso dessa lida constante.
Recurrent Sequence Evolution After Independent Gene Duplication
Authors: Dunk Samuel Hermann Alexander Von Der , Snel Berend 
Published: July 2020

Abstract
Background Convergent and parallel evolution provide unique insights into the mechanisms of natural selection. Some of the most striking convergent and parallel (collectively recurrent ) amino acid substitutions in proteins are adaptive, but there are also many that are selectively neutral. Accordingly, genome-wide assessment has shown that recurrent sequence evolution in orthologs is chiefly explained by nearly neutral evolution. For paralogs, more frequent functional change is expected because additional copies are generally not retained if they do not acquire their own niche. Yet, it is unknown to what extent recurrent sequence differentiation is discernible after independent gene duplications in different eukaryotic taxa. Results We develop a framework that detects patterns of recurrent sequence evolution in duplicated genes. This is used to analyze the genomes of 90 diverse eukaryotes. We find a remarkable number of families with a potentially predictable functional differentiation following gene duplication. In some protein families, more than ten independent duplications show a similar sequence-level differentiation between paralogs. Based on further analysis, the sequence divergence is found to be generally asymmetric. Moreover, about 6\% of the recurrent sequence evolution between paralog pairs can be attributed to recurrent differentiation of subcellular localization. Finally, we reveal the specific recurrent patterns for the gene families Hint1/Hint2, Sco1/Sco2 and vma11/vma3. Conclusions The presented methodology provides a means to study the biochemical underpinning of functional differentiation between paralogs. For instance, two abundantly repeated substitutions are identified between independently derived Sco1 and Sco2 paralogs. Such identified substitutions allow direct experimental testing of the biological role of these residues for the repeated functional differentiation. We also uncover a diverse set of families with recurrent sequence evolution and reveal trends in the functional and evolutionary trajectories of this hitherto understudied phenomenon.
Face mask use among individuals who are not medically diagnosed with COVID-19: A lack of evidence for and against and implications around public health recommendations.
Authors: Marasinghe Keshini Madara 
Published: July 2020

Abstract
IntroductionSince the beginning of the COVID-19 outbreak, public health professionals have been constantly making decisions on face mask use among individuals who are not medically diagnosed with COVID-19 or “healthy individuals” to limit the spread of COVID-19. While some countries have strongly recommended face masks for “healthy individuals”, other countries have recommended against it. Public health recommendations that have been provided to this population since the beginning of the outbreak have been controversial, contradicting, and inconsistent around the world. The purpose of this paper is to understand available evidence around the effectiveness or ineffectiveness of face mask use in limiting the spread of COVID-19 among individuals who have not yet been diagnosed with COVID-19 and most importantly, to understand the state of knowledge that the public health recommendations that have been provided since the beginning of the COVID-19 outbreak are based on.MethodsA systematic review was conducted to identify studies that investigated the use of face masks to limit the spread of COVID-19 among “healthy individuals”.ResultsNo studies were found, demonstrating a lack of evidence for and against face mask use suggesting implications around public health recommendations provided to “healthy individuals” since the beginning of the COVID-19 outbreak.ConclusionsThree and a half months into the COVID-19 outbreak (December 2019 – 2nd week of April 2020), there are no peer-reviewed scientific studies that have investigated the effectiveness or ineffectiveness of face mask use among “healthy individuals”. Yet, very strong public health recommendations have been provided on whether they should or should not wear face masks to limit the spread of COVID-19. A lack of scientific evidence heavily questions the basis of these public health recommendations provided at a very early, yet a crucial stage of an outbreak. This finding and a further look at public health recommendations conclude that there is a clear need for more concentrated research around face mask use among healthy individuals as well as public health recommendations that are evidence-based; precautionary in the absence of evidence; based on benefit-risk assessment; transparent; and globally aligned in order to provide the most successful guidelines during an infectious disease outbreak.
HTLV screening of blood donors using chemiluminescence immunoassay in three major provincial blood centers of China
Authors: Zhao Junpeng , Zhao Feixue , Han Wei , Xu Xiaoxuan , Wang Lilin , Li Ran , Li Tong , Wu Linfeng , Du Dandan , Zeng Xuezhen , Cui Xiujuan , Chen Yunlong , Zeng Jinfeng , Wang Lunan 
Published: July 2020

Abstract
Background: Human T-cell lymphotropic virus (HTLV) remains a major safety concern for blood supplies. Despite many HTLV positive cases being reported in southeastern China, the detection of HTLV has not been prioritized in routine blood screening. Additionally, data on the prevalence of HTLV infection among blood donors is also limited. The objective of this study was to investigate the prevalence of HTLV among blood donors in three Chinese provinces through their representative blood centers, to evaluate the feasibility of chemiluminescence immunoassay (CLIA) for blood screening.Methods: From November 2018 to March 2019, blood plasma samples were collected from Hebei, Changsha, and Shenzhen blood centers and were screened for the HTLV-1/2 antibody using a CLIA and enzyme-linked immunosorbent assay (ELISA). This was followed by confirmatory tests using INNO-LIA HTLV I/II.Results: A total of 59,929 blood donations were collected and screened for HTLV-1/2. The reactive rate of CLIA and ELISA among donations in the Shenzhen blood center (0.0943%, 27/28, 621) was higher than Hebei (0.0248%, 4/16,144), and Changsha (0.0198%, 3/15,164) (p < 0.05). After confirmation, 3 samples were confirmed as indeterminate for HTLV antibodies, and only one sample from the Shenzhen blood center was confirmed as HTLV-1. The overall prevalence of HTLV-1/2 was 1.67 per 100 000 (1/59,929). The HTLV-infected blood came from a 32-year-old first-time female donor with a high school degree, who belonged to the SHE ethnic minority and was born in the Fujian province.Conclusions: In summary, the overall prevalence of HTLV-1/2 among blood donors in the three blood centers in China remains relatively low. However, blood donations with positive or indeterminate results for HTLV antibodies reminded us of the importance of HTLV screening among blood donors in China.