bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case report of carcinoma of uterine cervix throwing heterochronous metastasis to the skin, spleen, and pancreas: the role of multimodality treatment approach
Authors: Gupta P. K. , Lal P. , Tiwari A. 
Published: December 2019

Abstract
Background
Cancer of cervix often fails locally and/or within the pelvis. One to two percent of cervical squamous cell carcinoma patients have lung metastases at presentation, and 5–35% develop pulmonary metastases later on. Common sites of metastases are the liver, bone, and bowel. We report a rare case presentation of cervical squamous cell cancer where heterochronous metastasis occurred in the skin, spleen, and pancreas without loco-regional recurrence and skipping of visceral organs such as the lung, liver, and brain.

Case presentation
A 55-year-old, postmenopausal lady presented with a complaint of bleeding of the vagina for 2 months duration. Cervical biopsy revealed squamous cell carcinoma of the cervix, and she was staged as a case of FIGO stage IIIB. She received external beam-beam radiotherapy of 50 Gy in 25 fractions along with concurrent weekly cisplatin at 35 mg/m2 followed by 3 fractions of intracavitary brachytherapy of 6 Gy each. After 30 months of follow-up, she presented with a skin lesion of 6 × 5 cm2 in the infrascapular region for 2 months duration. Biopsy revealed metastatic squamous cell carcinoma. Her metastatic work-up revealed no other lesions. Palliative radiotherapy to local site of 8 Gy in single fraction was delivered. The lesion disappeared within 4 weeks. She was given 6 cycles of cisplatin and paclitaxel salvage chemotherapy. After 30 months of follow-up, she presented with a skin lesion of 6 × 5 cm2 in the infrascapular region. Biopsy revealed metastatic squamous cell carcinoma. Her metastatic work-up revealed no other lesions. Palliative radiotherapy to the local site was planned, and a dose of 8 Gy in a single fraction was delivered. The lesion disappeared within 4 weeks. She was given 6 cycles of cisplatin and paclitaxel salvage chemotherapy. Six months after the completion of salvage therapy, she reported with the complaints of recurrent bouts of hematemesis and melena. Her CECT scan revealed 2 × 1.5 cm2 growth in the body of the pancreas and a subcentric splenic hilum node. She underwent open splenectomy with distal pancreatectomy. Histopathology report showed metastatic infiltration in pancreatic tissue by squamous cell carcinoma and one metastatic node in the splenic hilum. Post-treatment, 6 months, the patient was asymptomatic with no recurrence.

Conclusions
This is a rare heterochronous metastatic presentation of cervical cancer without loco-regional recurrence and visceral organs such as the lung, liver, and brain. The optimal treatment remains undefined for these patients. Multimodality treatment is necessary to manage the patients.
Antecedent and consequences of organizational identification: a study in the tourism sector of Sikkim
Authors: Subba Deepak 
Published: December 2019

AbstractOrganizational identification has been identified as an important construct in behavioral research. It has been viewed from different perspectives such as marketing, organizational behavior, human resource management, and psychology. This study is conducted in organizational behavior context among the employees of tourism industry in Sikkim and gave some important contribution which can be useful to researchers and practitioners. With the application of social identity theory, the study investigated the antecedent and consequences of organizational identification. To test the research model, self-reports of 246 respondents are used and for analyzing data explorative factor analysis, confirmatory factor analysis and structural equation modeling were applied. Findings of the study suggested that perceived organizational support emerged as an antecedent of organizational identification, whereas job satisfaction and knowledge sharing behavior emerged as consequences of organizational identification.
Hemogram parameters in the patients with subacute thyroiditis
Authors: Cengiz Hasret , Varım Ceyhun , Demirci Taner , Cetin Sedat 
Published: December 2019

Background & Objective: Subacute Granulomatous Thyroiditis (De Quervain’s Thyroiditis) is an acute painful inflammatory disease of the thyroid. We aimed to investigate easily accessible and cheap hemogram based parameters of Neutrophil to Lymphocyte Ratio (NLR), Platelet to Lymphocyte Ratio (PLR), and Mean Platelet Volume (MPV) in the follow up of inflammatory thyroid disease.
Methods: Patients admitted to Sakarya University Education and Research Hospital Endocrinology and Metabolism Outpatient Clinic and diagnosed as Subacute Granulomatous Thyroiditis between May 2017 and November 2018 were included in the study. Hemogram, thyroid function tests and acute phase values ​​of these patients were recorded and compared with the values ​​after treatment and disease recovery. On the sixth month, thyroid function tests were repeated and the rate of permanent hypothyroidism was screened. The relationships between initial hemogram parameters and acute phase reactants were evaluated.
Results: Total 71 patients were included in our study. 60 (84.5%) were female and 11 (15.5%) were male. The F/M ratio was found to be 6/1. Mean age was 43 ± 9.95 years. Receiver Operating Characteristics (ROC) Curve Analysis was performed and values for Area Under the Curve (AUC) for NLR and PLR, respectively, were 0.739 (95% CI 0.657-0.820 p<0.0001) and 0.772 (95% CI 0.694-0.850 p<0.0001), which are significant and associated with disease activity. However, the AUC for MPV parameter was: 0.578 (95% CI 0.484-0.672 P: 0.10) and was not significant. The cut off values defined as 2.4 (80% sensitivity and 51% specificity) for NLR and 146.84 (83% sensitivity and 54% specificity) for PLR for the acute phase of the disease. In the Correlation Analysis, NLR and PLR values ​​were significantly correlated with ESR and CRP parameters, which are the most commonly used acute phase reactants.
Conclusion: According to the present study, we believe that the NLR and PLR parameters will be of benefit in the follow-up the disease, accurately demonstrate the inflammatory load in the acute phase of the disease, and correlate with the common acute phase reactants.
doi: https://doi.org/10.12669/pjms.36.2.1063
How to cite this:Cengiz H, Varim C, Demirci T, Cetin S. Hemogram parameters in the patients with subacute thyroiditis. Pak J Med Sci. 2020;36(2):240-245. doi: https://doi.org/10.12669/pjms.36.2.1063
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Additional chromosomal abnormalities in Philadelphia positive chronic myeloid leukemia
Authors: Arif Sunila Tashfeen , Mahmood Rafia , Khan Saleem Ahmed , Khadim Tahir 
Published: December 2019

Objective: To determine the frequency of additional chromosomal abnormalities in Philadelphia chromosome positive Chronic Myeloid Leukemia (CML) by conventional cytogenetic analysis.
Methods: This descriptive cross sectional study was conducted at Armed Forces Institute of Pathology (AFIP), Rawalpindi, from January 2012 to December 2016. A total number of 528 newly diagnosed CML patients were included in the study. The subjects were tested for the presence of Philadelphia (Ph) chromosome and other additional cytogenetic abnormalities by conventional cytogenetic analysis interpreted according to International System of Human Cytogenetic Nomenclature (ISCN) criteria. Molecular analysis for BCR-ABL was also performed for each patient. The additional cytogenetic abnormalities were then classified into major route abnormalities and minor route abnormalities.
Results: Out of the 528 newly diagnosed CML patients, 378 (71.6%) were males and 150 (28.4%) were females. The age of patients ranged between 18 to 74 years. Four hundred and ninety-eight (94.3%) patients showed Philadelphia chromosome on karyotyping while 30 (5.7%) were negative for the Philadelphia chromosome. On analysis of these 498 Philadelphia positive patients, additional cytogenetic aberrations were detected in 26 (4.9%) patients. Of these, 7 (1.3%) had major route abnormalities while 19 (3.6%) had minor route abnormalities.
Conclusion: The frequency of additional chromosomal abnormalities in our study were not in accordance with previous local and international studies.
doi: https://doi.org/10.12669/pjms.36.2.1384
How to cite this:Tashfeen S, Mahmood R, Khan SA, Khadim T. Additional chromosomal abnormalities in Philadelphia positive chronic myeloid leukemia. Pak J Med Sci. 2020;36(2):208-212. doi: https://doi.org/10.12669/pjms.36.2.1384
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uniportal VATS technique for primary spontaneous pneumothorax: An analysis of 46 cases
Authors: Kapicibasi Hasan Oğuz 
Published: December 2019

Objective: In the treatment of primary spontaneous pneumothorax (PSP), the influence of safety and applicability of uniportal video assisted thoracoscopic surgery (VATS) bullectomy/blebectomy and pleurectomy method were evaluated in 46 patients.
Methods: Between November 2010 and January 2019, 46 patients (36 males, 10 females; mean age 24.2 years; range 16-36 years) undergoing uniportal video thoracoscopic bullectomy/blebectomy and apical pleurectomy for primary spontaneous pneumothorax were evaluated retrospectively at Canakkale Onsekiz Mart University (COMU). One patient underwent surgery for the second time after three months for contralateral pneumothorax and counted as two different patients, hence forty seven operations were performed in total. The cases were evaluated in terms of age, gender, comorbidity, duration of hospital stay, histopathological diagnosis, postoperative morbidity and mortality.
Results: Right surgical intervention was performed in 20 cases (42.6%) and left surgical intervention in 27 cases (57.6%). A total of 15 (31.9%) surgical operations were performed during the first attack, 30 (63.8%) during the second attack and 2 (4.3%) during third and more attacks. There was prolonged air leakage in all patients operated during the first episode. All cases underwent wedge resection and pleurectomy with endoscopic stapes. None of the patients required thoracotomy. Postoperative drainage period was between 2-7 days (mean: 4.1) and the duration of hospitalization was between three to eight days. Postoperative pain and paraesthesia were observed in eight cases. Prolonged air leakage was observed in five cases.
Conclusion: With video thoracoscopic uniportal technique, not only lung biopsy and resection but also bullectomy/blebectomy and pleurectomy operations can be performed safely in the treatment of PSP. In view of this information, minimally invasive techniques are seen as more advantageous than conventional techniques.
doi: https://doi.org/10.12669/pjms.36.2.1556
How to cite this:Kapicibasi HO. Uniportal VATS technique for primary spontaneous pneumothorax: An analysis of 46 cases. Pak J Med Sci. 2020;36(2):224-228. doi: https://doi.org/10.12669/pjms.36.2.1556
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DNA methylation changes in biomarker loci occur early in cancer progression
Authors: Vrba Lukas , Futscher Bernard W. 
Published: December 2019

Tumor-specific DNA methylation can be used for cancer diagnostics and monitoring. We have recently reported a set of DNA methylation biomarkers that can distinguish plasma samples from lung cancer patients versus healthy controls with high sensitivity and specificity. Furthermore, the DNA methylation signal from the biomarker loci detected in plasma samples correlated with tumor size and decreased after surgical resection of lung tumors. In order to determine the timing of DNA methylation of these loci during carcinogenesis and thus the potential of the biomarkers to detect early stages of the disease we analyzed the DNA methylation of the biomarker loci in five precancerous conditions using available data from the GEO database. We found that the DNA methylation of the biomarker loci is gained early in carcinogenesis since most of the precancerous conditions already have biomarker loci hypermethylated. Moreover, these DNA methylation biomarkers are able to distinguish between precancerous lesions with malignant potential and those that stay benign where data is available. Taken together, the biomarkers have the potential to detect the earliest cancer stages; the only limitation to detection of cancer from plasma samples or other liquid biopsies is the timing when tumors start to shed enough DNA into body fluids.
Sistema de gestão para um hospital de referência
Authors: Martin Luana Bassetto , Juliani Carmen Maria Casquel Monti , Lima Stella Godoy Silva e , Silva Karen Aline Batista da , Baptista Simone Cristina Paixão Dias 
Published: December 2019

Objetivo: conhecer o perfil e demanda de urgência e emergência encaminhadas ao serviço de alta complexidade antes e após a implantação de um sistema de regulação. Metodologia: estudo retrospectivo avaliado por análise estatística de relatórios administrativos do Hospital de Clinicas de Botucatu, considerados dois períodos entre 2015 e 2018, após aprovação pelo Comitê de Ética em Pesquisa, sendo N=8921 antes e N= 10450 após implantação de sistema de regulação. Resultados: observa-se prevalência da população residente do município de Botucatu, sexo masculino com média de idade 40 anos, com entrada no serviço devido fratura, trauma, afecções cardíacas e acidente vascular cerebral com tempo médio de regulação de 1 hora, 43 minutos e 48 segundos. Conclusão: encaminhamentos classificados como urgência mínima representaram 55,1% das solicitações, 12,5% dos encaminhamentos foram contrarreferenciados. O conhecimento do fluxo e demanda contribui para a regulação do paciente.
Fabrication of an electrowetting liquid microlens array for a focus tunable integral imaging system
Authors: Kim Cheoljoong , Shin Dooseub , Koo Gyohyun , Won Yong Hyub 
Published: December 2019

The main advantage of an integral imaging system is that it does not cause a vergence-accommodation conflict to the viewer, as happens in other types of three-dimensional (3D) display systems. However, it still has the disadvantage of having a limited depth range. In this Letter, the fabrication of the electrowetting liquid lens array with an adjustable focal length is presented. With the liquid microlens array, we propose a focus tunable integral imaging system having an enhanced expressible depth range. The fabricated lens array has 1 mm lens pitch, 100 µm sidewall,

20

×
14

m
m

total size,

−

542

to

−

89

D focus variability, and 11.6 ms response time. The fabrication process, a measurement of optical characteristics, and a demonstration of the focus tunable integral imaging system are presented in this Letter.
Multiplex volatile organic compound Raman sensing with nanophotonic slot waveguides functionalized with a mesoporous enrichment layer
Authors: Zhao Haolan , Baumgartner Bettina , Raza Ali , Skirtach Andre , Lendl Bernhard , Baets Roel 
Published: December 2019

We report, to the best of our knowledge, the first Raman sensor for broadband vapor-phase volatile organic compounds (VOCs) based on silicon nitride waveguides functionalized with a mesoporous silica top-cladding. The Raman response of low-concentration VOC gases is evanescently probed via a centimeter-long functionalized slot waveguide. Thanks to the four-orders-of-magnitude concentration factor offered by the mesoporous coating, the detection limit of acetone, ethanol, and isopropyl alcohol (IPA) is determined to be 594, 157, and 53 ppm, respectively, with 1 s measurement time in the current setup. Capable of multiplex gas sensing in a complex matrix through fast and reversible adsorption, the demonstration paves the way to on-site continuous VOC monitoring.
High-spectral-purity photon generation from a dual-interferometer-coupled silicon microring
Authors: Liu Yingwen , Wu Chao , Gu Xiaowen , Kong Yuechan , Yu Xinxin , Ge Renyou , Cai Xinlun , Qiang Xiaogang , Wu Junjie , Yang Xuejun , Xu Ping 
Published: December 2019

We experimentally demonstrate a high-spectral-purity photon source by designing a dual-Mach–Zehnder-interferometer-coupled silicon ring resonator, wherein the linewidths of pump and signal (idler) resonances can be engineered independently. A high spectral purity of

95
%
±
1.5
%

is obtained via a time-integrated

g

(
2
)

correlation measurement, which exceeds the theoretical 93% bound of a traditional ring’s spontaneous four-wave-mixing photon source. This source also possesses high performance in other metrics including a measured coincidence of 9599 pairs/s and a preparation heralding efficiency of 52.4% at a relatively low pump power of 61 µW as well as high drop-to-through suppression of 20.2 dB. By overcoming the trade-off between spectral purity and brightness in the post-filtering way, such a method guarantees bright pure photons and will pave the way for development of on-chip quantum information processing with improved operation fidelity and efficiency.
Holocausto y dibujos: la caricatura como resistencia
Authors: Quijada Gonzalo Leiva 
Published: December 2019

El articulo establece una relación entre la memoria del dibujo y los acontecimientos históricos del holocausto, ejemplificado en la figura del artista Kurt Herdan, u vida, sus motivos y su imaginario del dibujo y la caricatura. En todos ellos, hay trazas de una memoria que establece una resistencia artística frente a los embates del poder.
Palabras clave: holocausto; caricatura; resistencia.
Edição e engajamento político: a Editora L&PM nos anos 1970
Authors: Maués Flamarion 
Published: December 2019

Este artigo discute a fusão entre ação editorial e engajamento político oposicionista no Brasil na década de 1970, durante a ditadura iniciada em 1964, analisando a atuação dos editores responsáveis pela Editora L&PM, de Porto Alegre, criada em 1974, e procurando entender como essa ação a transformou em uma casa editorial politicamente ativa, em âmbito regional e nacional. Acredito que este estudo colaborará para a compreensão da síntese entre edição e política no Brasil no período final da ditadura, bem como das relações e mediações então estabelecidas. Além disso, permitirá uma reflexão sobre o papel que a edição política desempenhou no Brasil, buscando uma visão mais ampla do seu significado.
Palavras-chave: edição política; história editorial no Brasil; editoras de oposição.
Desenho rococó nos manuscritos do Brasil do século XVIII: caminhos e expressões
Authors: Silva de Souza Antonio Wilson 
Published: December 2019

Este artigo aborda origens, características e difusão do rococó, destacando, de modo especial, a ornamentação dos manuscritos do Brasil no século XVIII. Apesar dos estudos realizados sobre o estilo, as peculiaridades do desenvolvimento do rococó merecem uma análise sempre atualizada e pormenorizada, sobretudo para se entender melhor a influência que a gravura francesa exerceu sobre a criação, o desenvolvimento e a propagação do estilo na Europa e no Brasil. A ênfase na ornamentação gráfica fundamenta o exame das suas particularidades, ao possibilitar maior entendimento sobre o significado que o desenho assume como manifestação autêntica da arte, o que permite afirmar que o rococó se tornou uma singular realidade na expressão da arte brasileira.
Palavras-chave: ornato; rococó; arte brasileira.
Mistérios da canção regionalista
Authors: Dias da Costa Antonio Maurício 
Published: December 2019

Este texto percorre alguns lugares na obra literária de Apollinaire que são motivados pelas errâncias urbanas do autor. Uma modernização do olhar ali se evidencia: investido de um viés alegórico e mítico, a favor de um inusitado sentimento de estranhamento do banal cotidiano, esse olhar concorre a um jogo lírico, por vezes elegíaco, que o escritor estabelece entre tempos, objetos e figuras. O errante apollinairiano concede, assim, polissêmica profundidade para o espaço e o tempo vividos, sobre fundo de uma despersonalização crescente imposta pela metrópole moderna. A adesão do poeta às formas da vida citadina revela-se, por fim, potência órfica de transfiguração lírica e mítica do presente.
Palavras-chave: errância; modernidade; Apollinaire.
Accuracy of air temperature forecasts and its use for prediction of the reference evapotranspiration
Authors: Silva Claudio Ricardo da , Lucas Andrade Barbosa  , Finzi Rafael Resende , Riberio Bruno Teixeira , Dias Nildo da Silva 
Published: December 2019

The objective of this study was to verify the quality of the short-term forecasts made by some web sites, as well as the potential of its use in estimating reference evapotranspiration (ETo). For the period 2012-2013, every 4-days, the maximum (Tmax) and minimum (Tmin) air temperature forecasts for horizons of 24, 48, 72 and 96 hours provided by public sites for Uberlandia-MG were collected and used for calculating the reference evapotranspiration (ETo) by the Hargreaves-Samani (HS) calibrated equation. The sites www.accuweather.com (WEATHER); www.cemig.com.br (CEMIG); jornaldotempo.uol.com.br; (JORNAL) and www.climatempo.com.br (CLIMA) were evaluated. For the same period, the meteorological data were taken at the National Institute of Meteorology (www.inmet.gov.br). The performance of the Tmax and Tmin forecasts as well as the ETo estimates were made by regression analysis, the mean bias error (MBE), root mean square error (RMSE) and t-test. For all sites, there was a better performance in the prediction of Tmin when compared to Tmax, especially by a reduction in errors (MBE and RMSE) and an increase in coefficients b and R2. For ETo, the site CLIMA had lowest MBE and RMSE (0.9 mm d-1) following by the WEATHER and JORNAL. On the other hand, the site CEMIG presented higher values for MBE (-1.3 mm d-1) and RMSE (1.6 mm d-1). There was no worsening with an increase of the forecast horizon in these indices, except for R² values. The site CLIMA was the only one that did not differ significantly from the ETo values observed. The results of diagnostic verification procedures indicate the potential use of air temperature forecasts in irrigation management.