bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digging deeper into volatile organic compounds associated with cancer
Authors: Janfaza Sajjad , Khorsand Babak , Nikkhah Maryam , Zahiri Javad 
Published: November 2019

AbstractVolatile organic compounds (VOCs), produced and emitted through the metabolism of cancer cells or the body’s immune system, are considered novel cancer biomarkers for diagnostic purposes. Of late, a large number of work has been done to find a relationship between VOCs’ signature of body and cancer. Cancer-related VOCs can be used to detect several types of cancers at the earlier stages which in turn provide a significantly higher chance of survival. Here we aim to provide an updated picture of cancer-related VOCs based on recent findings in this field focusing on cancer odor database.
Making Meaning of Justice Ideals for Intimate Partner Violence: Reflections on Restorative Justice
Authors: Ehret Stephanie 
Published: November 2019

AbstractThis is an examination of Barbara Hudson’s theory of social justice and her delineation of three principles at the centre of restorative justice—discursiveness, reflectiveness and relationalism. It explores how justice might be done for intimate partner violence (IPV) through the principles. Part of a larger project, this study consists of critically informed one-on-one interviews with 12 women who have experienced IPV. It finds the women conceptualize justice socially and reconfigure and relocate the principles to prioritize social collaborations and protective solutions in extralegal locations with persons who understand the complexities and challenges of the issue.
Joint estimation of gravity anomalies using second and third order potential derivatives
Authors: Romeshkani Mohsen , Sharifi Mohammad A , Tsoulis Dimitrios 
Published: November 2019

Abstract
Satellite gradiometry data provide the framework for estimating and validating Earth's gravity field from second and third order derivatives of the Earth's gravitational potential. Such procedures are especially useful when applied locally, as they relate to local and regional characteristics of the real gravity field. In the present study a joint inversion procedure is proposed for the estimation of gravity anomalies at sea surface level from second and third order potential derivatives, based on a standard Gauss-Markov estimation model. The estimation procedure is applied for a test area stretching over Iran involving simulated grids from GOCE-only model GGM_TIM_R05 at GOCE altitude and gravity anomalies recovered at sea level. In order to validate the proposed estimation three different reductions have been considered independently, namely the removal of the long-wavelength part of the observed field through a global gravity model, the removal of the high-frequency part of the field through the incorporation of a topographic/isostatic gravity model and the application of variance component estimation. The application of a global gravity model leads to an improvement in the individual component estimation of the order of magnitude 3 per cent to 73 per cent, with a significant reduction in bias to 4 mGal. Smoother gradient components can come out according to removing the topography and taking into account for isostasy that improved up results of recovery to 25 per cent for the radial second order derivative. Finally, the implementation of variance component estimation leads to no significant improvement in results of recovered gravity anomalies.
HIV infection risk and condom use among sex workers in Senegal: evidence from the list experiment method
Authors: Lépine Aurélia , Treibich Carole , Ndour Cheikh Tidiane , Gueye Khady , Vickerman Peter 
Published: November 2019

Abstract
Social desirability bias, which is the tendency to under-report socially undesirable health behaviours, significantly distorts information on sensitive behaviours that is gained from self-reports. As a result, self-reported condom use among high-risk populations is thought to be systematically over-reported, and it is impossible to identify the determinants of condom use. The main objective of the article is to elicit unbiased information on condom use among female sex workers (FSWs) using the double list experiment method to analyse the role of HIV infection and exposure to HIV prevention methods in condom use. More specifically, the difference in levels of condom use between HIV-positive and HIV-negative FSWs is estimated. In addition, the role of FSWs’ registration and participation in a pre-exposure prophylaxis (PrEP) demonstration project in condom use is considered. A list experiment was designed to elicit condom use information from 786 FSWs in Senegal who were surveyed in 2015 and 2017. Using the list experiment method, participants were randomly assigned to one of two groups (treatment or control) and were asked to report the number of statements they agreed with. Respondents assigned to the control group were presented with three non-sensitive items, whereas those allocated to the treatment group were presented with the same three statements plus the sensitive item (e.g. ‘I used a condom during my last intercourse with a client’). Comparing the average number of sentences that were agreed with in both groups provides an estimation of the condom use rate in the treatment group and estimating such prevalence for several sub-groups allows the role of HIV infection risk in condom use to be identified. The percentage of FSWs using condoms in their last sexual intercourse with a client was 80% in 2015 and 78% in 2017, which was significantly lower than the 97% obtained in the face-to-face surveys in both waves. When estimating condom use among sub-groups with the list experiment method, we found that condom use among HIV-positive FSWs was only 34%, which was 47 percentage points lower than condom use among HIV-negative FSWs. We also found that registered FSWs are more likely to use condoms than clandestine FSWs. However, we did not find any difference in condom use between FSWs who were enrolled in the PrEP demonstration project and those who were not enrolled. Health policies should therefore aim to increase condom use among HIV-positive FSWs.
Exploring exploration: the role of affective states as forces that hinder change
Authors: Brusoni Stefano , Laureiro-Martínez Daniella , Canessa Nicola , Zollo Maurizio 
Published: November 2019

AbstractIn this article we argue that in order to understand failure or success in adapting to environmental change, we should better understand why people hesitate to pursue novel choices. This article asks: what forces hinder individuals’ exploration choices of different alternatives, and hence their ability to learn from them? To answer this question, this article looks to the cognitive sciences to identify a set of plausible mechanisms that hinder people’s tendency to explore. So far, “exploration” has been studied as a relatively monolithic behavior. Instead, we propose that exploration can be characterized in terms of some distinctive forces behind it. On one hand, agents experience “attachment” to choices that proved successful in the past, and hence comfort when sticking with them. On the other hand, they also experience concerns about less familiar options, as they lack knowledge about “distant” choices that have not been tried for a long time, or ever. We propose that high attachment is related to anxiety, and high distance to fear. Both these negative affective states hinder exploration. We find and discuss preliminary and tentative evidence of this effect.
2030 Countdown to combating malnutrition in Burundi: comparison of proactive approaches for case detection and enrolment into treatment
Authors: Odjidja Emmanuel Nene , Christensen Cathryn , Gatasi Ghislaine , Hakizimana Sonia , Murorunkwere Honorine , Masabo Jean-Berchmans , Meguid Tarek 
Published: November 2019

Abstract

Background
Burundi has one of the highest rates of malnutrition in the world, particularly chronic malnutrition, which affects 55% of all children &lt;5 y of age. Although it rolled out a national treatment programme to combat all forms of malnutrition, enrolment of children remains difficult. In this study, we use observational data from two screening approaches to assess the effectiveness in detection and enrolment into treatment.

Methods
Individual data from each screening approach was classified as either acutely malnourished or normal and either chronically malnourished or normal using a cut-off z-score between −2 and 2.

Results
While the Global Acute Malnutrition rate for the community-based mass screening was 8.3% (95% CI 5.6 to 11), with 8% enrolled in treatment, that of clinic-based systematic screening was 14.1% (95% CI 12.2 to 16.1), 98% of which were enrolled in treatment. Clinic systematic screening was 1.82 times (OR, 95% CI 1.26 to 2.62, p&lt;0.001) and 1.35 times (95% CI 1.09 to 1.68, p=0.06) more likely to detect acute and chronic malnutrition, respectively, than community-based mass screening.

Conclusions
Although different mechanisms are relevant to proactively detect cases, strengthening the health system to systematically screen children could yield the best results, as it remains the primary contact for the sicker population, who may be at risk of increased infection as a result of underlying malnutrition.
Lessons learned implementing a complex and innovative patient safety learning laboratory project in a large academic medical center
Authors: Businger Alexandra C , Fuller Theresa E , Schnipper Jeffrey L , Rossetti Sarah Collins , Schnock Kumiko O , Rozenblum Ronen , Dalal Anuj K , Benneyan James , Bates David W , Dykes Patricia C 
Published: November 2019

AbstractObjectiveThe objective of this paper is to share challenges, recommendations, and lessons learned regarding the development and implementation of a Patient Safety Learning Laboratory (PSLL) project, an innovative and complex intervention comprised of a suite of Health Information Technology (HIT) tools integrated with a newly implemented Electronic Health Record (EHR) vendor system in the acute care setting at a large academic center.Materials and MethodsThe PSLL Administrative Core engaged stakeholders and study personnel throughout all phases of the project: problem analysis, design, development, implementation, and evaluation. Implementation challenges and recommendations were derived from direct observations and the collective experience of PSLL study personnel.ResultsThe PSLL intervention was implemented on 12 inpatient units during the 18-month study period, potentially impacting 12,628 patient admissions. Challenges to implementation included stakeholder engagement, project scope/complexity, technology/governance, and team structure. Recommendations to address each of these challenges were generated, some enacted during the trial, others as lessons learned for future iterative refinements of the intervention and its implementation.ConclusionDesigning, implementing, and evaluating a suite of tools integrated within a vendor EHR to improve patient safety has a variety of challenges. Keys to success include continuous stakeholder engagement, involvement of systems and human factors engineers within a multidisciplinary team, an iterative approach to user-centered design, and a willingness to think outside of current workflows and processes to change health system culture around adverse event prevention.
Topical Toxicity Profiles of Some Aliphatic and Aromatic Essential Oil Components Against Insecticide-Susceptible and Resistant Strains of German Cockroach (Blattodea: Ectobiidae)
Authors: Oladipupo S O , Hu X P , Appel A G 
Published: November 2019

AbstractToxicity profiles of four aliphatic (α-pinene, cyclononanone, limonene, nerolidol), four aromatic (β-thujaplicin, carvacrol, eugenol, tropolone) essential oil components (EOCs), and permethrin were investigated against three strains of German cockroach, Blattella germanica (L.). The strains include a susceptible strain (S), and two multi-resistant strains – strains D and E. Also, a synergism bioassay, using piperonyl butoxide (PBO) was conducted. The most toxic EOCs were aromatic EOCs carvacrol, eugenol, and tropolone, followed by aliphatic EOC limonene; all had LD50 values of &lt;0.7 mg/µl. Four of the EOCs were equally toxic against all the strains, with carvacrol being the most toxic, followed by eugenol, tropolone, and α–pinene. The other four EOCs were more toxic against strain S than against the two resistant strains. Permethrin was significantly more toxic to strain S (LD50 = 0.056 µg/µl) compared with the resistant strains (D = 2.138 µg/µl, E = 1.730 µg/µl). Toxicity of aliphatic EOCs correlated positively with their molecular weight against strain E only, whereas both molecular weight and vapor pressure of aromatic EOCs correlated significantly with toxicity in all strains. Strain D exhibited the greatest resistance (RR of 6.7) to EOCs, and synergism to the aliphatic EOC cyclononanone. Clear synergism with PBO was observed in permethrin against resistant strains, but not in all of the EOCs, suggesting multiple resistance mechanisms in the resistant cockroaches. These findings give insight on the potential of EOCs to be incorporated as parts of an IPM approach to managing insecticide resistant German cockroaches.
Gender-based Persecution as a Crime Against Humanity
Authors: Grey Rosemary , O’Donohue Jonathan , Rosenthal Indira , Davis Lisa , Llanta Dorine 
Published: November 2019

Abstract
In 2019, in the case of Prosecutor v. Al Hassan, Prosecutor Bensouda sought confirmation of the first charge of gender-based persecution at the International Criminal Court (ICC). Given that no previous international tribunal had jurisdiction to prosecute persecution on ‘gender’ grounds, this was an important first step towards developing the jurisprudence on this crime. Meanwhile, the Rome Statute’s definition of ‘gender’ has been discussed and debated in the International Law Commission (ILC) in the context of the ongoing development of draft articles on crimes against humanity. In the context of these recent developments in the ICC and ILC, this article closely examines the Rome Statute’s definition of ‘gender’, and explores what ‘gender’ means as a ground of persecution. We conclude that as a result of the definition agreed to at the 1998 Rome Diplomatic Conference, the Rome Statute’s definition of ‘gender’ captures the social aspects of gender, consistent with widely accepted practice at the time of the Statute's adoption and in the two decades since. These are important facts to hold on to as the focus on the definition of ‘gender’ intensifies, the ICC’s jurisprudence on gender-based persecution evolves, and efforts advance to develop a new convention on crimes against humanity.
Transcription factor TCP20 regulates peach bud endodormancy by inhibiting DAM5/DAM6 and interacting with ABF2
Authors: Wang Qingjie , Xu Gongxun , Zhao Xuehui , Zhang Zejie , Wang Xuxu , Liu Xiao , Xiao Wei , Fu Xiling , Chen Xiude , Gao Dongsheng , Li Dongmei , Li Ling 
Published: November 2019

Abstract
The dormancy-associated MADS-box (DAM) genes PpDAM5 and PpDAM6 have been shown to play important roles in bud endodormancy; however, their molecular regulatory mechanism in peach is unclear. In this study, by use of yeast one-hybrid screening, we isolated a TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR transcription factor, PpTCP20, in the peach cultivar ‘Zhongyou 4’ (Prunus persica var. nectarina). The protein was localized in the nucleus and was capable of forming a homodimer. Electrophoretic mobility shift assays demonstrated that PpTCP20 binds to a GCCCR element in the promoters of PpDAM5 and PpDAM6, and transient dual luciferase experiments showed that PpTCP20 inhibited the expression of PpDAM5 and PpDAM6 as the period of the release of flower bud endodormancy approached. In addition, PpTCP20 interacted with PpABF2 to form heterodimers to regulate bud endodormancy, and the content of abscisic acid decreased with the release of endodormancy. PpTCP20 also inhibited expression of PpABF2 to regulate endodormancy. Taken together, our results suggest that PpTCP20 regulates peach flower bud endodormancy by negatively regulating the expression of PpDAM5 and PpDAM6, and by interacting with PpABF2, thus revealing a novel regulatory mechanism in a perennial deciduous tree.
Slingshot prominences: coronal structure, mass loss and spin down
Authors: Jardine M , Cameron A Collier , Donati J-F , Hussain G A J 
Published: November 2019

Abstract
The structure of a star’s coronal magnetic field is a fundamental property that governs the high-energy emission from the hot coronal gas and the loss of mass and angular momentum in the stellar wind. It is, however, extremely difficult to measure. We report a new method to trace this structure in rapidly-rotating young convective stars, using the cool gas trapped on coronal field lines as markers. This gas forms “slingshot prominences” which appear as transient absorption features in H-α. By using different methods of extrapolating this field from the surface measurements, we determine locations for prominence support and produce synthetic H-α stacked spectra. The absorption features produced with a potential field extrapolation match well this those observed, while those from a non-potential field do not. In systems where the rotation and magnetic axes are well aligned, up to $50\%$ of the prominence mass may transit the star and so produces a observable feature. This fraction may fall as low as $~2\%$ in very highly inclined systems. Ejected prominences carry away mass and angular momentum at rates that vary by two orders of magnitude, but which may approach those carried by the stellar wind.
Determination of the star-spot covering fraction as a function of stellar age from observational data
Authors: Nichols-Fleming Fiona , Blackman Eric G 
Published: November 2019

ABSTRACT
The association of star-spots with magnetic fields leads to an expectation that quantities which correlate with magnetic field strength may also correlate with star-spot coverage. Since younger stars spin faster and are more magnetically active, assessing whether star-spot coverage correlates with shorter rotation periods and stellar youth tests these principles. Here, we analyse the star-spot covering fraction versus stellar age for M-, G-, K-, and F-type stars based on previously determined variability and rotation periods of over 30 000 Kepler main-sequence stars. We determine the correlation between age and variability using single and dual power-law best fits. We find that star-spot coverage does indeed decrease with age. Only when the data are binned in an effort to remove the effects of activity cycles of individual stars, do statistically significant power-law fits emerge for each stellar type. Using bin averages, we then find that the star-spot covering fraction scales with the X-ray to bolometric ratio to the power λ with 0.22 ± 0.03 &lt; λ &lt; 0.32 ± 0.09 for G-type stars of rotation period below 15 d and for the full range of F- and M-type stars. For K-type stars, we find two branches of λ separated by variability bins, with the lower branch showing nearly constant star-spot coverage and the upper branch λ ∼ 0.35 ± 0.04. G-type stars with periods longer than 15 d exhibit a transition to steeper power law of λ ∼ 2.4 ± 1.0. The potential connection to previous rotation-age measurements suggesting a magnetic breaking transition at the solar age, corresponding to period of 24.5 is also of interest.
An ionized accretion disc wind in Hercules X-1
Authors: Kosec P , Fabian A C , Pinto C , Walton D J , Dyda S , Reynolds C S 
Published: November 2019

ABSTRACT
Hercules X-1 is one of the best-studied highly magnetized neutron star X-ray binaries with a wealth of archival data. We present the discovery of an ionized wind in its X-ray spectrum when the source is in the high state. The wind detection is statistically significant in most of the XMM–Newton observations, with velocities ranging from 200 to 1000 km s−1. Observed features in the iron K band can be explained by both wind absorption and a forest of iron emission lines. However, we also detect nitrogen, oxygen, and neon absorption lines at the same systematic velocity in the high-resolution Reflection Grating Spectrometer grating spectra. The wind must be launched from the accretion disc, and could be the progenitor of the ultraviolet absorption features observed at comparable velocities, but the latter likely originate at significantly larger distances from the compact object. We find strong correlations between the ionization level of the outflowing material and the ionizing luminosity as well as the superorbital phase. If the luminosity is driving the correlation, the wind could be launched by a combination of Compton heating and radiation pressure. If instead the superorbital phase is the driver for the variations, the observations are likely scanning the wind at different heights above the warped accretion disc. If this is the case, we can estimate the wind mass outflow rate, corrected for the limited launching solid angle, to be roughly 70 per cent of the mass accretion rate.
Recurrent Collection of Drosophila melanogaster from Wild African Environments and Genomic Insights into Species History
Authors: Sprengelmeyer Quentin D , Mansourian Suzan , Lange Jeremy D , Matute Daniel R , Cooper Brandon S , Jirle Erling V , Stensmyr Marcus C , Pool John E 
Published: November 2019

AbstractA long-standing enigma concerns the geographic and ecological origins of the intensively studied vinegar fly, Drosophila melanogaster. This globally distributed human commensal is thought to originate from sub-Saharan Africa, yet until recently, it had never been reported from undisturbed wilderness environments that could reflect its precommensal niche. Here, we document the collection of 288 D. melanogaster individuals from multiple African wilderness areas in Zambia, Zimbabwe, and Namibia. The presence of D. melanogaster in these remote woodland environments is consistent with an ancestral range in southern-central Africa, as opposed to equatorial regions. After sequencing the genomes of 17 wilderness-collected flies collected from Kafue National Park in Zambia, we found reduced genetic diversity relative to town populations, elevated chromosomal inversion frequencies, and strong differences at specific genes including known insecticide targets. Combining these genomes with existing data, we probed the history of this species’ geographic expansion. Demographic estimates indicated that expansion from southern-central Africa began ∼13,000 years ago, with a Saharan crossing soon after, but expansion from the Middle East into Europe did not begin until roughly 1,800 years ago. This improved model of demographic history will provide an important resource for future evolutionary and genomic studies of this key model organism. Our findings add context to the history of D. melanogaster, while opening the door for future studies on the biological basis of adaptation to human environments.