bluuebunny/crossref_metadata_2025_split huggingface dataset:
P.41 Measurement of Pressure-dependent Intra-Beat Changes in Carotid Pulse Wave Velocity using Image-Free Fast Ultrasound
Authors: Raj Kiran V , Nabeel P M , Joseph Jayaraj , Chandran Dinu , Sivaprakasam Mohanasankar 
Published: December 2020

Abstract
Background
The clinical significance of pressure-dependent intra-beat changes in local pulse-wave velocity (C) has recently come to light [1]. While reported methods require arterial pressure and diameter measurements from a single site to assess intra-beat changes in C, we present an image-free fast ultrasound device that performs this by capturing diameter waveforms from two proximal locations on an artery.

Methods
The functionality was assessed on eight normotensive participants (26 ± 4 years). By perturbing blood pressure through a short duration moderate lower body negative pressure intervention [2], CD and CF pulse wave velocities corresponding to diastolic and 80% of peak pressure were measured from the carotid artery. Human NIBP system (ADInstruments, India) was used for monitoring continuous pressure.

Results
The device captured dual-diameter waveforms and evaluated CD and CF, with a beat-to-beat variation <8% during baseline. CD was smaller than CF (p < 0.001), 4.2 ± 0.5 m/s versus 4.6 ± 0.7 m/s during baseline and 3.7 ± 0.6 m/s versus 3.9 ± 0.7 m/s during intervention. Concomitant to the drop in group-average diastolic (17%) and systolic (18%) pressures during the intervention, CD and CF dropped by 14% and 16%, respectively. The statistically significant correlation (r > 0.6, p < 0.001) of CD and CF with the diastolic and systolic pressures for each individual was preserved even after adjusting for heart-rate.

Conclusions
The device demonstrated its functionality and reliably measured the incremental nature of C. Its pressure-dependent intra-beat variations and inter-beat dynamics during the intervention concurred with literature. Further studies are underway to demonstrate the potential use of the device in vascular research and clinical applications.
P.47 Feasibility Evaluation of Imaging-Free Ultrasound Technology to Measure Diameters of Brachial and Radial Arteries for Assessment of Endothelial Function
Authors: Chandran Dinu , Joseph Jayaraj , Sen Sakshi , Raj Kiran , Nabeel P. M. , Deepak Kishore Kumar 
Published: December 2020

Abstract
Background
Ultrasonographic imaging to record changes in peripheral arterial diameter associated with Flow mediated dilatation or Low flow mediated constriction is routinely used to assess various facets of vascular endothelial function. Imaging poses many challenges including requirement of costly ultrasound machines, trained manpower to perform imaging and effort-intensive steps to analyse the images subsequently using manual or automated methods. We tested the feasibility and validity of using an imaging-free technology to record resting arterial diameters of brachial and radial arteries.

Methods
Eight healthy volunteers initially underwent ultrasonographic imaging (M7, Mindray; Shenzhen, P.R. China) of brachial artery and proximal radial artery. The brachial and radial artery ‘zones’ thereby identified through imaging were surface marked on subject’s arm. Imaging-free ARTSENS® Pen device [1] (Healthcare Technology Innovation Centre, IIT Madras, India) consisting of highly integrated hardware for operating a single element broadband ultrasound transducer (centre-frequency = 5 MHz, spatial half angle <1.3 degrees, diameter = 5 mm) in pulse-echo mode was used to track detectable arterial wall motion and measure end-diastolic diameters from previously identified brachial and radial ‘zones’.

Results
End-diastolic diameters measured by ARTSENS® Pen decreased significantly on moving from brachial to radial zone identified by imaging (4.34 ± 1.07 mm vs 2.05 ± 0.43 mm; p < 0.0001) and correlated strongly with imaging-based measurements (r = 0.93; p < 0.0001).

Conclusion
ARTSENS® Pen device offers feasible and valid imaging-free solution to measure peripheral arterial diameters which could potentially be employed for assessment of vascular endothelial function.
P.50 Radial Artery Phenotyping in Fibromuscular Dysplasia Through Ultra-High Frequency Ultrasound: A Radiomic Approach
Authors: Poli Federica , Bruno Rosa Maria , Faita Francesco , Khettab Hakim , Azizi Michel , Vitali Saverio , Cosottini Mirco , Caramella Davide , Ghiadoni Lorenzo , Taddei Stefano , Boutouyrie Pierre , Persu Alexandre , Jeunemaitre Xavier , Lorthioir Aurélien 
Published: December 2020

Abstract
Rationale and Aim
This study is aimed at identifying possible patterns of vascular wall disarray and remodeling in radial arteries of patients with fibromuscular dysplasia (FMD), by means of ultrahigh frequency ultrasound (UHFUS).

Methods
UHFUS scans of the radial arteries and of 30 FMD patients and 30 healthy controls were obtained by VevoMD (70 MHz probe, FUJIFILM, VisualSonics, Toronto, Canada). 10 end-diastolic frames for each subject were analyzed. 74 radiomic features and 4 engineered parameters were extracted: intima-media thickness (IMT) and adventitia thickness (AT), an adjunctive acoustic interface for each layer (IMT and AT triple signal). The extracted parameters were used to train classification models, using Support Vector Machine Linear (SVM), K-Nearest Neighbors (KNN), Logistic Regression, Linear Discriminant Analysis (LDA). The models were then tested on an independent validation population (38 FMD patients and 28 healthy subjects).

Results
IMT (185 ± 46 vs 168 ± 37, p =) and AT (104 ± 34 vs 96 ± 35, p = 0.004) were significantly higher in FMD than in controls. IMT and AT triple signal were also more frequent in FMD than in control images (p < for both). The most accurate classification models were LDA (sensitivity = 0.67, specificity = 0.76, accuracy = 0.71, AUC = 0.71) and Logistic Regression (sensitivity = 0.71, specificity = 0.72, accuracy = 0.71, AUC = 0.71). The models showed and accuracy of about 70% when tested on the validation population.

Conclusions
Wall ultrastructure of radial arteries of FMD patients is extensively altered: IMT and AT are thickened and the first and/or second layer of the arterial wall is splitted, showing a triple signal feature. Radiomic descriptors combined with engineered parameters allow to distinguish between radial images from FMD patients and controls with a 70% accuracy.
P.53 Ascending Aorta Diameter and Pulse Wave Velocity are Increased and Local Hemodynamic is Disrupted in Patients with Blunt Traumatic Thoracic Aortic Injury Treated by TEVAR
Authors: Guala Andrea , Sala Daniel Gil , Ruiz-Muñoz Aroa , Garcia-Reyes Marvin , Dux-Santoy Lydia , Teixido-Tura Gisela , Tello Cristina , Valente Filipa , Lopez-Sainz Angela , Galian Laura , Gutierrez Laura , Johnson Kevin , Wieben Oliver , Ferreira Ignacio , Evangelista Arturo , Bellmunt-Montoya Sergi , Rodriguez-Palomares Jose 
Published: December 2020

Abstract
Background
Thoracic endovascular aortic repair (TEVAR) is becoming the preferred treatment option to repair the proximal descending aorta after rupture following blunt traumatic injury. However, hemodynamic and mechanic implications of this intervention are poorly understood. Exploiting the possibilities of 4D flow magnetic resonance imaging, hemodynamics, stiffness and local dilation in the ascending aorta in patients following aortic repair by TEVAR are studied.

Methods
Fifteen apparently healthy individuals who underwent TEVAR implantation after traumatic descending aortic injury and 44 healthy volunteers (HV) underwent 4D flow-MRI. Ascending aorta pulse wave velocity was computed [1]. Moreover, at eight planes equally distributed in the ascending aorta systolic flow reversal ratio, i.e. relative amount of backward flow during systole, and in-plane rotational flow, measuring the strength of helical flow, were computed [2,3].

Results
TEVAR patients and HV did not differ in terms of age, sex, BSA and blood pressure (Table). However, compared to HV, TEVAR patients showed reduced in-plane rotational flow in the distal ascending aorta in patients with TEVAR and increased backward systolic flow in the whole ascending aorta (Figure). Patients with TEVAR had a stiffer ascending aorta, with pulse wave velocity higher compared control (7.8 ± 4.2 vs 5.3 ± 1.9, p = 0.004). Finally, aortic root and ascending aorta diameters were larger in TEVAR patients compared to HV (Table).

Conclusions
The implantation of TEVAR in apparently healthy individuals after traumatic rupture of the proximal descending aorta is associated with altered hemodynamics, higher stiffness and larger aortic diameter in the region proximal to the TEVAR.

Table

Healthy volunteers
TEVAR patients
p

N
44
15

Age [years]
40 ± 12
43 ± 10
0.392

Sex [% male]
66
80
0.075

Years from intervention [years]
N/A
10.3 ± 6.4
N/A

Body surface area [m2]
1.87 ± 0.15
1.96 ± 0.23
0.088

Systolic blood pressure [mmHg]
127 ± 19
131 ± 15
0.389

Diastolic blood pressure [mmHg]
70 ± 11
74 ± 9
0.198

Aortic root diameter [mm]
31 ± 4
34 ± 4
0.026

Ascending aorta diameter [mm]
28 ± 4
32 ± 3
0.003

Ascending aorta PWV [m/s]
5.3 ± 1.9
7.8 ± 4.2
0.004
P.56 Differences in Vascular Effects Between One Session of Moderate-Intensity Continuous Physical Exercise and High-Intensity Interval Physical Exercise in Individuals with High Blood Pressure
Authors: Rodrigues Sara , Verardino Renata G S , Costa Marcel J A , Duenhas-Berger Ana Luíse , Costa-Hong Valéria , Bortolotto Luiz A 
Published: December 2020

Abstract
Purpose
To compare augmentation index (AIx) between one Moderate-intensity continuous physical exercise (MICPE) and one High-intensity interval physical exercise (HIIPE) session in normal/high normal blood pressure (BP) (120–140 for systolic and 80–90 mmHg for diastolic). Additionally, to compare two AIx methods (SphygmoCor® and Arteriograph®) [1].

Methods
Exercise intensity and energy expenditure (equalizing) were according to the cardiopulmonary stress test. Individuals were randomized to exercise sessions, performed as cross-over. AIx were analyzed at baseline, immediately after and 24hours after MICPE and HIIPE session and compared among all times. ΔAIxHIIPE (AIxHIIPE - AIxBaseline) and ΔAIxMICPE were calculated. Correlation and agreement analysis was performed between AIx methods.

Results
Individuals (n = 23; 78% women; 48 ± 1 years; systolic/diastolicBP = 125 ± 2/84 ± 1 mmHg) had lower AIxSphygmoCor® at MICPE compared to baseline and to 24 hours MICPE (27.2 ± 2.2 vs 32.8 ± 1 and 31.0 ± 2.5%; p < 0.01). AIxSphygmoCor® was lower in HIIPE than other times (23.2 ± 2.4 vs baseline 32.8 ± 1.9 p < 0.01; vs MICPE 27.2 ± 2.2; p = 0.039; vs 24 hours MICPE 31.0 ± 2.5; p < 0.01 and vs 24 hours HIIPE 32.2 ± 2.0%; p < 0.01). AIxArteriograph® was lower in HIIPE (16.0 ± 3.7%) than baseline (28.9 ± 3.4%; p = 0.001), 24 hours MICPE (25.7 ± 4.0%; p = 0.008) and 24 hours HIIPE (29.5 ± 3.9%; p = 0.005). ΔAIxHIIPE was greater than ΔAIxMICPE (−9.37 vs −5.15; p = 0.028). AIxArteriograph® showed a positive correlation with AIxSphygmoCor® (r = 0.793; p < 0.01) and showed agreement.

Conclusion
Regardless of intensity, one exercise session improves AIx. The effect seems to be greater after HIIPE than MICPE.
P.61 Impact of Kidney Transplantation on Arterial Reservoir-Wave Analysis
Authors: Côté Nadège , Philibert Emy , Paré Mathilde , Goupil Rémi , Fortier Catherine , Schultz Martin G. , Sharman James E. , Agharazii Mohsen 
Published: December 2020

Abstract
Purpose/Background/Objective
According to reservoir-wave approach (RWA) arterial pressure is the sum of a reservoir pressure (RP) accounting for dynamic storage and release of blood from arteries, and an excess pressure (XSP) analogous to flow. RP is the minimal left ventricular work required to generate aortic flow, while XSP corresponds to surplus cardiac workload. We have previously shown that kidney transplantation (KTx) improves aortic stiffness [1], however, by adding renal vessels to existing vascular network, KTx may increase cardiac output. Thus, we aimed to examine whether XSP increases after KTx.

Methods
Before and 3 months after KTx, carotid pressure waves were recorded using arterial tonometry, calibrated using brachial diastolic and mean blood pressure. Using pressure only approach, reservoir-wave analysis was used to derive RP, XSP and their integrals (RPI, XSPI). RWA parameters were compared with Wilcoxon non-parametric test using SPSS 26.0.

Results
75 patients (69% male, mean age 51 ± 13 years) were assessed. Three months after KTx, both carotid RP (121.2 ± 20.7 vs 103.5 ± 15.7, p < 0.001) and RPI (11192.52 ± 2763.11 vs 9531 ± 1978, p < 0.001) decreased significantly, but carotid XSP and XSPI remained unchanged. Carotid systolic (131.0 ± 23.2 vs 114.1 ± 15.5, p < 0.001) and diastolic (83.4 ± 11.9 vs 72.8 ± 9.93, p < 0.001) blood pressures were also reduced.

Conclusion
KTx decreased reservoir pressure, suggesting a decrease in minimal cardiac workload. However, we did not see an increase in excess pressure or its integral, suggesting that addition of a donor renal artery does not significantly alter cardiac outflow and excess workload 3 months after KTx.
P.62 Assessment of Isoflavone and Ethanolic Extract of Inonotus Obliquus on Experimentally Induced Diabetes
Authors: Duru Kingsley , Hildreth Cara , Avolio Alberto P. , Phillips Jacqueline K. , Butlin Mark 
Published: December 2020

Abstract
Purpose
Studies support beneficial effects of isoflavones, but antidiabetic effects of these agents remains unconfirmed [1,2]. This pilot study investigates isoflavones and Inonotus obliquus (chaga) extract effects on diabetes.

Methods
Diabetes was induced (streptozotocin 65 mg/kg, nicotinamide 110 mg/kg) in 9 male Wistar rats (12 weeks old). 9 additional rats were healthy controls. After 4 weeks animals were treated for 4 weeks with vehicle, isoflavone (200 mg/kg/day), or Inonotus obliquus (100 mg/kg/day). Blood pressure and metabolic caging were measured weekly. Glucose tolerance, renal function (serum creatinine, blood urea nitrogen (BUN) level, creatinine clearance rate) and heart, kidney and body weight were assessed at the end-point.

Results
The diabetes group had 1 death (ketoacidosis). Untreated diabetic rats showed glucose intolerance (area under curve (AUC) = 64.87 ± 9.71 min × mmol/L), ameliorated with isoflavone (AUC = 14.78 ± 1.1 min × mmol/L, p < 0.001) and chaga extract (AUC = 30.4 ± 13.5 min × mmol/L, p < 0.001). Body weight was lower but not significantly different in untreated (491.3 ± 35.3 g) versus isoflavone (521.0 ± 7.0 g, p > 0.05) and chaga treatment (552.0 ± 91.9 g, p > 0.05). Kidney mass index was higher in untreated diabetic rats (0.51 ± 0.06) compared to isoflavone (0.36 ± 0.02, p < 0.05) but not significantly different in chaga (0.39 ± 0.06, p > 0.05) treatment. Food and water intake and 24 hr urine output was not significantly different. No difference in serum creatinine, BUN, or creatinine clearance rate were found.

Conclusions
Initial results indicate renal benefits of isoflavone and chaga extract in an animal model of diabetes but without other cardiovascular impact. The study was underpowered to detect all differences and further work, including translating results to humans, is required.
P.64 Active Vitamin D Treatment Does Not Improve Arterial Stiffness and Markers of Cardio-Renal Risk in Patients with Type 2 Diabetes and Stage 3 Chronic Kidney Disease: a Randomised Controlled Trial
Authors: Fountoulakis Nikolaos , Ayis Salma , Mangelis Anastasios , Panagiotou Angeliki , Flaquer Maria , Stoilov Stanimir , Maltese Giuseppe , Viberti GianCarlo , Thomas Stephen , Gnudi Luigi , Karalliedde Janaka 
Published: December 2020

Abstract
Background and Aims
Active vitamin D [1,25(OH)2D3] deficiency is a potential modifiable risk factor for cardiovascular (CVD) and renal disease in patients with type 2 diabetes (T2DM) and stage 3/4 chronic kidney disease (CKD). Exact mechanisms are unclear. Arterial stiffness is an independent predictor of CVD. Tere is limited data on the effect of active vitamin D treatment on arterial haemodynamics in this patient population.

Materials and Methods
We performed a 48 week duration single centre randomised double blind placebo controlled trial on the impact of calcitriol 0.25 mcg od in patients with T2DM and stage 3 CKD. Primary endpoint was change in Ao-PWV (index of arterial stiffness) measured by applanation tonometry (Sphygmocor system). Secondary endpoints included albuminuria (albumin excretion rate-AER) and changes in other indices of central haemodynamics.

Results
127 (male 70%) patients were randomised to calcitriol (n = 64) or placebo (n = 63). Baseline, mean ± SD, values were: age 64.2 ± 7.7, eGFR 43.2 ± 20.2 ml/min, SBP 146.2 ± 19.9 mmHg, Ao-PWV 11.6 ± 3.3 m/s, and AER median (IQR) 50.51 (11.5 to 188.6) mcg/min. There was no significant mean (95% CI) change in Ao-PWV as compared to placebo of 0.05 m/s (−0.68 to 0.78) vs 0.23 m/s (−0.46 to 0.93) with a between treatment mean (95% CI) difference for Ao-PWV of 0.19 (−0.81 to 1.19) m/s (p = 0.71). No significant effect of calcitriol treatment observed on augmentation index or albuminuria.

Conclusion
In T2DM patients with stage 3 CKD, 48 week treatment with calcitriol as compared to placebo does not improve Ao-PWV, albuminuria or other indices of central haemodynamics.
P.65 Increased Biomarkers of Endothelial Dysfunction and Thrombotic Microenvironment in Patients with Autoimmune Rheumatic Disorders Free from Cardiovascular Comorbidities
Authors: Gavriilaki Eleni , Anyfanti Panagiota , Douma Stella , Gkaliagkousi Eugenia 
Published: December 2020

Abstract
Purpose/Background/Objectives
Cardiovascular risk is increased in patients with autoimmune rheumatic disorders [1]. Endothelial and platelet MVs (EMVs, PMVs) are small vesicles (0.1–1 μm) released from plasma membrane and represent novel markers of endothelial dysfunction and thrombosis. Their levels increase substantially in patients with cardiovascular diseases [2,3]. We tested whether EMVs and PMVs are increased in patients with autoimmune rheumatic disorders in the absence of cardiovascular comorbidities.

Methods
Consecutive patients with rheumatoid arthritis or systemic lupus erythematosus were studied, provided they were free from cardiovascular comorbidities (hypertension, diabetes, heart disease, history of cardiovascular or cerebrovascular events). We additionally used (a) a control group consisting of healthy volunteers and (b) a reference group including patients with stable coronary artery disease (CAD). MVs were measured by a standardized flow cytometry protocol [2,3].

Results
We studied 74 participants: 17 patients with autoimmune rheumatic diseases; 34 healthy volunteers, and 23 stable CAD patients. Patients with rheumatic diseases presented increased levels of both EMVs (283.3 ± 195.0/μL vs 168.5 ± 54.8/μL, p = 0.029) and PMVs (374.0 ± 275.3/μL vs 225.7 ± 101.1/μL, p = 0.046) compared to controls. In addition, they presented similar levels of EMVs compared to CAD patients (283.3 ± 195.0/μL vs 297.0 ± 211.8/μL, p = 0.846), whereas PMVs were substantially elevated in the latter (374.0 ± 275.3/μL vs 1034.8 ± 374.0/μL, p = 0.029).

Conclusions
Endothelial dysfunction and thrombotic predisposition, shown by increased levels of EMVs and PMVs, respectively, may be evidenced in patients with autoimmune rheumatic diseases, even in the absence of cardiovascular comorbidities and before the establishment of clinically evident cardiovascular complications. In these patients, levels of EMVs appear to be comparable with those of stable CAD patients.

Acknowledgements
This research is co-financed by Greece and the European Union (European Social Fund-ESF) through the Operational Programme “Human Resources Development, Education and Lifelong Learning 2014–2020” in the context of the project “Evaluation of novel markers of endothelial dysfunction and thrombotic microenvironment in patients with rheumatoid arthritis: association with markers of subclinical inflammation and cardiovascular damage (MIS 5047870)”.
Manajemen Pembinaan Profesionalisme Guru Taman Kanak-Kanak/Pendidikan Anak Usia Dini Berbasis Budaya Jawa
Authors: Aminah Siti 
Published: December 2020

Tujuan penelitian ini adalah untuk: 1) Mendekripsikan Manajemen Pembinaan Profesionalisme Guru TK/PAUD Berbasis Budaya Jawa di Gugus PAUD VI Kecamatan Pakem tahun 2018/2019. 2) Mengkaji Faktor-faktor pendukung dan penghambat. 3) Mengetahui hasil yang dicapai. Penelitian ini menggunakan pendekatan deskritif kualitatif dan dilakukan di Gugus PAUD VI Kecamatan Pakem Sleman, Yogyakarta. Data dikumpulkan dari narasumber yang terdiri dari ketua gugus, kepala sekolah, pengawas, guru, komite sekolah, dokumen-dokumen, serta peristiwa-peristiwa yang berkaitan dengan proses Manajemen Pembinaan Profesionalisme Guru TK/PAUD Berbasis Budaya Jawa di Gugus PAUD VI Kecamatan Pakem. Data dikumpulkan dengan metode wawancara, observasi, dan dokumentasi. Teknik analisis data yang dipergunakan dalam penelitian ini analisis data kualitatif dengan tahapan pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Penelitian ini secara umum menyimpulkan bahwa manajemen pembinaan profesionalisme guru TK/PAUD berbasis budaya Jawa pada tingkat Gugus VI berjalan dengan melibatkan semua anggota gugus. Keberhasilan program pembinaan profesionalisme guru selanjutnya ditentukan oleh manajemen pembinaan di tingkat masing-masing TK/PAUD.
PERAN DKPP DALAM MENEGAKKAN KODE ETIK PENYELENGGARA PEMILU DAN MEWUJUDKAN PILKADA BERMARTABAT
Authors: Feka Mikhael , Witarti Rabawati Dwityas , Arman Yohanes , Taemenas Egidius 
Published: December 2020

Abstract
The Honorary Council for General Election Organizers (DKPP) is an element in the general election execution together with the General Election Commission (KPU) and the General Election Supervision Body (Bawaslu). The main function of the DKPP is to enforce the ethical code for the general election organizers. A dignified general election and election of district heads starts from the general election organizers who are supposed to uphold the general election ethics, although that does not constitute a single factor, in a sense that a dignified general election should be the responsibility of all elements of general election that include the organizers, the pair candidates, political parties, success team, civil servants, national and districts governments, as well as other stakeholders. The problem is that the DKPP’s authority is limited to the execution of the general election and does not cover the whole system of the carrying out of the general election and therefore it is difficult to realize a dignified election of district heads, despite the fact that a dignified election will bring about dignified leaders. As a democratic country, Indonesia is supposed to consider not only ethical code for the general election organizers but also ethical code for the whole implementation of the general election.