bluuebunny/crossref_metadata_2025_split huggingface dataset:
Takotsubo cardiomyopathy in COVID-19: a case report. Haemodynamic and therapeutic considerations
Authors: van Osch Dirk , Asselbergs Folkert W , Teske Arco J 
Published: August 2020

Abstract

Background
Cardiovascular complications are increasingly recognized during the current coronavirus disease 2019 (COVID-19) pandemic. Myocardial injury is most commonly described and its underlying mechanism is believed to be multifactorial. Next to Type 2 ischaemia, COVID-19 may lead to (peri)myocarditis or Takotsubo (or stress) cardiomyopathy.

Case summary
A 72-year-old woman was admitted to the intensive care unit for mechanical ventilation because of respiratory insufficiency secondary to COVID-19 viral pneumonia. Seven days after admission, she developed new negative T-waves and a prolonged QTc interval on electrocardiography (ECG). Troponin levels were mildly elevated. Echocardiography showed a poor left ventricular systolic function with apical ballooning consistent with the diagnosis Takotsubo cardiomyopathy. Seven days afterwards, the ECG and troponin levels normalized. Echocardiography showed improvement of left ventricular systolic function, however with persistent hypokinesia of the apical segments. Coronary artery disease was excluded using coronary computed tomography angiography. The patient was discharged home and follow-up echocardiography after 3 months showed normal contractility of the apical myocardial segments, with normalization of the left ventricular systolic function, as expected in Takotsubo cardiomyopathy.

Discussion
COVID-19 caregivers should be aware of Takotsubo cardiomyopathy as complication of COVID-19, since regular use of QT-prolonging drugs combined with prolongation of the QTc interval in Takotsubo cardiomyopathy may lead to life-threatening arrhythmias. Furthermore, Takotsubo cardiomyopathy may lead to acute heart failure and even cardiogenic shock. Frequent ECG monitoring of COVID-19 patients therefore is of paramount importance and timely echocardiography should be obtained when ECG abnormalities or haemodynamical problems occur.
Quantitative assessment to the impact of InSAR ionospheric and tropospheric corrections on source parameter modelling: application to the 4th nuclear test, North Korea
Authors: Zhu Meng , Zeng Qiming , Jiao Jian 
Published: August 2020

SUMMARYAlthough many studies have revealed that the atmospheric effects of electromagnetic wave propagation (including ionospheric and tropospheric water vapour) have serious impacts on Interferometric Synthetic Aperture Radar (InSAR) measurement results, atmospheric corrections have not been thoroughly and comprehensively investigated in many well-known cases of InSAR focal mechanism solutions, which means there is no consensus on whether atmospheric effects will affect the InSAR focal mechanism solution. Moreover, there is a lack of quantitative assessment on how much the atmospheric effect affects the InSAR focal mechanism solution. In this paper, we emphasized that it was particularly important to assess the impact of InSAR ionospheric and tropospheric corrections on the underground nuclear explosion modelling quantitatively. Therefore, we investigated the 4th North Korea (NKT-4) underground nuclear test using ALOS-2 liters-band SAR images. Because the process of the underground nuclear explosion was similar to the volcanic magma source activity, we modelled the ground displacement using the Mogi model. Both the ionospheric and tropospheric phase delays in the interferograms were investigated. Furthermore, we studied how the ionosphere and troposphere phase delays could bias the estimation of Mogi source parameters. The following conclusions were drawn from our case study: the ionospheric delay correction effectively mitigated the long-scale phase ramp in the full-frame interferogram, the standard deviation decreased from 1.83 to 0.85 cm compared to the uncorrected interferogram. The uncorrected estimations of yield and depth were 8.44 kt and 370.33 m, respectively. Compared to the uncorrected estimations, the ionospheric correction increased the estimation of yield and depth to 9.43 kt and 385.48 m, while the tropospheric correction slightly raised them to 8.78 kt and 377.24 m. There were no obvious differences in the location estimations among the four interferograms. When both corrections were applied, the overall standard deviation was 1.16 cm, which was even larger than the ionospheric corrected interferogram. We reported the source characteristics of NKT-4 based on the modelling results derived from the ionospheric corrected interferogram. The preferred estimation of NKT-4 was a Mogi source located at 129°04′22.35‘E, 41°17′54.57″N buried at 385.48 m depth. The cavity radius caused by the underground explosion was 22.66 m. We reported the yield estimation to be 9.43 kt. This study showed that for large-scale natural deformation sources such as volcanoes and earthquakes, atmospheric corrections would be more significant, but even if the atmospheric signal did not have much complexity, the corrections should not be ignored.
Low-frequency earthquakes observed in close vicinity of repeating earthquakes in the brittle upper crust of Hakodate, Hokkaido, northern Japan
Authors: Yoshida Keisuke , Hasegawa Akira , Noguchi Shinako , Kasahara Keiji 
Published: September 2020

SUMMARY
We conducted a detailed investigation of an earthquake cluster distributed from the lower crust to the upper crust beneath Hakodate, Hokkaido, which included both low-frequency earthquakes (LFEs) and regular earthquakes. Relocated hypocentres clearly show that both the LFEs and regular earthquakes occurred close to each other in the brittle upper crust of this non-volcanic area, while only LFEs occurred in the lower crust. This observation indicates that LFEs can occur not only in the ductile lower crust, but also in the brittle upper crust, which suggests that LFEs can occur in an environment similar to that of regular earthquakes. Regular earthquakes that occur in close vicinity of LFEs have very similar waveforms and nearly overlapping source regions, which indicate that they reflect the repeated rupture of the same asperity patch on a fault. Temporally, the intervals between events in the repeating earthquake sequence were very short, thus suggesting that they were caused by a sudden increase in pore pressure. The cluster of LFEs and repeating earthquakes, which has a rod-like distribution extending from the bottom of the crust to the surface and tilted slightly eastward, might represent a pathway of aqueous fluid movement sourced from the subducting slab.
Follow-Up Household Serosurvey in Northeast Brazil for Zika Virus: Sexual Contacts of Index Patients Have the Highest Risk for Seropositivity
Authors: Magalhaes Tereza , Morais Clarice N L , Jacques Iracema J A A , Azevedo Elisa A N , Brito Ana M , Lima Priscilla V , Carvalho Gabriella M M , Lima Andreza R S , Castanha Priscila M S , Cordeiro Marli T , Oliveira Andre L S , Jaenisch Thomas , Lamb Molly M , Marques Ernesto T A , Foy Brian D 
Published: September 2020

Abstract

Background
Zika virus (ZIKV) is a mosquito-borne virus that is also transmitted sexually; however, the epidemiological relevance of ZIKV sexual transmission in endemic regions is unclear.

Methods
We performed a household-based serosurvey in Northeast Brazil to evaluate the differential exposure to ZIKV and chikungunya virus (CHIKV) among households. Individuals who participated in our previous arboviral disease cohort (indexes) were recontacted and enrolled, and their household members were newly enrolled.

Results
The relative risk of sexual partners being ZIKV-seropositive when living with a ZIKV-seropositive index participant was significantly higher, whereas this was not observed among nonsexual partners of the index. For CHIKV, both sexual and nonsexual partner household members living with a CHIKV-seropositive index had a significantly higher risk of being seropositive. In the nonindex-based dyadic and generalized linear mixed model analyses, the odds of sexual dyads having a concordant ZIKV plaque reduction neutralization test result was significantly higher. We have also analyzed retrospective clinical data according to the participants’ exposure to ZIKV and CHIKV.

Conclusions
Our data suggest that ZIKV sexual transmission may be a key factor for the high ZIKV seroprevalence among households in endemic areas and raises important questions about differential disease from the 2 modes of transmission.
Detection of Neisseria gonorrhoeae from Joint Aspirate by Metagenomic Sequencing in Disseminated Gonococcal Infection
Authors: Asmerom Betial , Drobish Ian , Winckler Britanny , Chiang Leslie , Farnaes Lauge , Beauchamp-Walters Julia , Bradley John S , Ramchandar Nanda 
Published: September 2020

Abstract
Disseminated gonococcal infection (DGI) often manifests as gonococcal arthritis and may carry significant morbidity. However, diagnosis remains elusive due to limited sensitivity of available diagnostic tests. We used metagenomic next-generation sequencing to detect Neisseria gonorrhoeae from culture-negative joint aspirates of 2 patients with clinically diagnosed DGI.
Constraints on the electron-to-proton mass ratio variation at the epoch of reionization
Authors: Levshakov S A , Kozlov M G , Agafonova I I 
Published: September 2020

ABSTRACT
Far-infrared fine-structure transitions of [C i] and [C ii] and rotational transitions of CO are used to probe hypothetical variations of the electron-to-proton mass ratio μ = me/mp at the epoch of reionization (z &gt; 6). A constraint on Δμ/μ = (μobs − μlab)/μlab = (0.7 ± 1.2) × 10−5 (1σ) obtained at $\bar{z} = 6.31$ is the most stringent up-to-date limit on the variation of μ at such high redshift. For all available estimates of Δμ/μ ranging between z = 0 and z ∼ 1100, the epoch of recombination, a regression curve Δμ/μ = kμ(1 + z)p, with kμ = (1.6 ± 0.3) × 10−8 and p = 2.00 ± 0.03, is deduced. If confirmed, this would imply a dynamical nature of dark matter/dark energy.
Towards a polarization prediction for LISA via intensity interferometry
Authors: Baumgartner Sandra , Bernardini Mauro , Canivete Cuissa José R , de Laroussilhe Hugues , Mitchell Alison M W , Neuenschwander Benno A , Saha Prasenjit , Schaeffer Timothée , Soyuer Deniz , Zwick Lorenz 
Published: September 2020

ABSTRACT
Compact Galactic Binary Systems with orbital periods of a few hours are expected to be detected in gravitational waves (GW) by Laser Interferometer Space Antenna (LISA) or a similar mission. At present, these so-called verification binaries provide predictions for GW frequency and amplitude. A full polarization prediction would provide a new method to calibrate LISA and other GW observatories, but requires resolving the orientation of the binary on the sky, which is not currently possible. We suggest a method to determine the elusive binary orientation and hence predict the GW polarization, using km-scale optical intensity interferometry. The most promising candidate is CD–30° 11223, consisting of a hot helium subdwarf with mB = 12 and a much fainter white dwarf companion, in a nearly edge-on orbit with period 70.5 min. We estimate that the brighter star is tidally stretched by 6 per cent. Resolving the tidal stretching would provide the binary orientation. The resolution needed is far beyond any current instrument, but not beyond current technology. We consider scenarios where an array of telescopes with km-scale baselines and/or the Very Large Telescope (VLT) and Extremely Large Telescope (ELT) are equipped with recently developed kilopixel sub-ns single-photon counters and used for intensity interferometry. We estimate that a team-up of the VLT and ELT could measure the orientation to ±1° at 2σ confidence in 24 h of observation.
Isotopic ratios in the red giant component of the recurrent nova T Coronae Borealis
Authors: Pavlenko Y V , Evans A , Banerjee D P K , Geballe T R , Munari U , Gehrz R D , Woodward C E , Starrfield S 
Published: September 2020

ABSTRACT
We report the determination of abundances and isotopic ratios for C, O, and Si in the photosphere of the red giant (RG) component of the recurrent nova (RN) T Coronae Borealis from new 2.284–2.402 μm and 3.985–4.155 μm spectroscopy. Abundances and isotopic ratios in the photosphere may be affected by (i) processes in the RG interior which are brought to the surface during dredge-up and (ii) contamination of the RG, either during the common envelope phase of the binary evolution or by material synthesized in RN eruptions, or a combination of the two. We find that the abundances of C, O, and Si are reasonably consistent with the expected composition of an RG after first dredge-up, as is the 16O/17O ratio. The 28Si/29Si ratio is found to be 8.6 ± 3.0, and that for 28Si/30Si is 21.5 ± 3.0. The 12C/13C ratio (10 ± 2) is somewhat lower than expected for first dredge-up. The 16O/18O ratio (41 ± 3) is highly inconsistent with that expected either from RG evolution (∼550) or from contamination of the RG by the products of a nova thermonuclear runaway. In particular, the C and O isotopic ratios taken in combination are a puzzle. We urge confirmation of our results using spectroscopy at high resolution. We also encourage a thorough theoretical study of the effects on the secondary star in an RN system of contamination by ejecta having anomalous abundances and isotopic ratios.
Limitations to the Right to Religious Freedom: Rethinking Key Approaches
Authors: Raza Farrah 
Published: September 2020

Abstract
The right to freedom of religion or belief is one of the most controversial fundamental human rights, and an increasing number of cases on religious freedom highlight the need for normative clarity about its limits. Courts across jurisdictions adopt different approaches to justifying limitations to religious claims in order to resolve conflicts. This article identifies current key approaches to justifying limits to religious practices before proposing a perfectionist version of the harm principle as an alternative. Section 1 sets out the complexities of determining the limitations to religious freedom. Section 2 identifies the shortcomings of four dominant approaches to limitations, and these include the following categories: (i) practices deemed to be against the liberal democratic order; (ii) practices that breach the duty of neutrality; (iii) practices that do not constitute a core religious belief; and (iv) the choice of alternatives. Section 3 proposes a typology of harms to the autonomy of others as a model for limitations to religious freedom. Section 4 concludes by emphasizing the need for consistency in deciding limitations.
Henry James, The Outcry, and the Possibilities of Connoisseurship
Authors: Deli Margaret 
Published: September 2020

Abstract
This article reveals Henry James’s commitment to professional connoisseurship as a means of asserting control over a mass reading public. Focusing on The Outcry (1911), James’s last published novel, it demonstrates the author’s deployment of connoisseurial strategies to produce a text that, perhaps surprisingly, turns away from the performance of authorial nuance. A related strand of analysis situates The Outcry within the cultural and social context of the Edwardian art drain, the period of time when a significant number of British-owned art objects were sold to museums and private collectors, most often in the United States. I argue that in this text, James seizes upon the figure of the professional connoisseur as a cultural hero and proxy for the novelist author. At the same time, he makes a point of celebrating and promoting the autocratic power exercised by this figure. Although The Outcry is often disregarded as a simple, even superficial work, these moves articulate a complex manifestation of class conflict, aesthetic training, and cultural power. They simultaneously reflect James’s late-in-life conviction that connoisseurship might itself serve as a literary strategy for seeing and shaping meaning.
Assessing Agricultural Toxicity in Brazil: Advances and Opportunities in the 21st Century
Authors: da Silva Artur Christian Garcia , Sousa Isabelly Paula , dos Santos Thaís Rosa Marques , Valadares Marize Campos 
Published: September 2020

Abstract
Agriculture in the 21st century faces multiple challenges to produce food for the growing population using ethical/sustainable and efficient methods safely for humans and the environment. Brazil today is a world leader in terms of production of food of plant origin, both for human consumption and animal feed. Agriculture and livestock raising are critical economic activities in maintaining a positive balance in its economy. As a consequence, the registration and use of pesticides in Brazil have grown at an accelerated rate. This work shows the current situation in Brazil in terms of the prevailing laws about the registration of pesticides, with a focus on the toxicological aspects related to human health. The regulatory aspects of registration of pesticides in Brazil, the mandatory testing for evaluating pesticide toxicity, adoption of the Globally Harmonized System of Classification and Labeling of Chemicals, and recent progress toward nonanimal methods to toxicity evaluation were explored in this work. In this field, Brazil has advanced and there are opportunities and challenges. There is still much to be done and investments to be made so that Brazil can definitively consolidate its conduct within the context of a Modern Regulatory Toxicology, which has entered the 21st century.
Proteometabolomic characterization of apical bud maturation in Pinus pinaster
Authors: Valledor Luis , Guerrero Sara , García-Campa Lara , Meijón Mónica 
Published: August 2020

Abstract
Bud maturation is a physiological process that implies a set of morphophysiological changes that lead to the transition of growth patterns from young to mature. This transition defines tree growth and architecture, and in consequence traits such as biomass production and wood quality. In Pinus pinaster Aiton, a conifer of great timber value, bud maturation is closely related to polycyclism (multiple growth periods per year). This process causes a lack of apical dominance, and consequently increased branching that reduces its timber quality and value. However, despite its importance, little is known about bud maturation. In this work, proteomics and metabolomics were employed to study apical and basal sections of young and mature buds in P. pinaster. Proteins and metabolites in samples were described and quantified using (n)UPLC-LTQ-Orbitrap. The datasets were analyzed employing an integrative statistical approach, which allowed the determination of the interactions between proteins and metabolites and the different bud sections and ages. Specific dynamics of proteins and metabolites such as histones H3 and H4, ribosomal proteins L15 and L12, chaperonin TCP1, 14-3-3 protein gamma, gibberellins A1, A3 and A8, strigolactones and abscisic acid, involved in epigenetic regulation, proteome remodeling, hormonal signaling and abiotic stress pathways showed their potential role during bud maturation. Candidates and pathways were validated employing interaction databases and targeted transcriptomics. These results increase our understanding of the molecular processes behind bud maturation, a key step towards improving timber production and natural pine forests management in a future scenario of climate change. However, further studies are necessary using different P. pinaster populations that show contrasting wood quality and stress tolerance in order to generalize the results.
Newly emerged resistance-breaking variants of cucumber mosaic virus represent ongoing host-interactive evolution of an RNA virus
Authors: Heo Kyeong-Jae , Kwon Sun-Jung , Kim Mi-Kyeong , Kwak Hae-Ryun , Han Soo-Jung , Kwon Min-Jun , Rao A L N , Seo Jang-Kyun 
Published: September 2020

AbstractUnderstanding the evolutionary history of a virus and the mechanisms influencing the direction of its evolution is essential for the development of more durable strategies to control the virus in crop fields. While the deployment of host resistance in crops is the most efficient means to control various viruses, host resistance itself can act as strong selective pressure and thus play a critical role in the evolution of virus virulence. Cucumber mosaic virus (CMV), a plant RNA virus with high evolutionary capacity, has caused endemic disease in various crops worldwide, including pepper (Capsicum annuum L.), because of frequent emergence of resistance-breaking variants. In this study, we examined the molecular and evolutionary characteristics of recently emerged, resistance-breaking CMV variants infecting pepper. Our population genetics analysis revealed that the high divergence capacity of CMV RNA1 might have played an essential role in the host-interactive evolution of CMV and in shaping the CMV population structure in pepper. We also demonstrated that nonsynonymous mutations in RNA1 encoding the 1a protein enabled CMV to overcome the deployed resistance in pepper. Our findings suggest that resistance-driven selective pressures on RNA1 might have contributed in shaping the unique evolutionary pattern of CMV in pepper. Therefore, deployment of a single resistance gene may reduce resistance durability against CMV and more integrated approaches are warranted for successful control of CMV in pepper.
Early Effects of COVID-19 on Programs Providing Medications for Opioid Use Disorder in Jails and Prisons
Authors: Bandara Sachini , Kennedy-Hendricks Alene , Merritt Sydney , Barry Colleen L. , Saloner Brendan 
Published: August 2020

Objectives:
To describe how the novel coronavirus (COVID-19) pandemic has affected opioid agonist treatment (OAT) programs in jails and prisons.

Methods:
In May 2020, we conducted an online survey of 19 carceral systems that provided methadone and/or buprenorphine treatment for incarcerated populations before COVID-19. Eleven survey items examined challenges and changes to these programs as a result of the pandemic. Sixteen of 19 programs (84%) responded to the survey.

Results:
Ten out of 16 systems reported downsizing their OAT programs. Seven of 16 systems made changes to medication dispensation processes. Half of systems report challenges implementing physical distancing (n = 8), and/or obtaining personal protective equipment (n = 8). In 13 out of 16 systems some OAT program participants were released early due to COVID-19 infection risk.

Conclusions:
Jails and prisons with existing OAT programs have curtailed their operations in the context of the COVID-19 pandemic. Given the robust evidence base around OAT for treating opioid use disorder and averting overdose deaths, guidance is needed on maintaining and ramping up medication access as carceral facilities grapple with implementing COVID-19 mitigation.