bluuebunny/crossref_metadata_2025_split huggingface dataset:
Higher‐level phylogeny of longhorn beetles (Coleoptera: Chrysomeloidea) inferred from mitochondrial genomes
Authors: Nie Ruie , Vogler Alfried P. , Yang Xing‐Ke , Lin Meiying 
Published: August 2020

AbstractCerambycidae (longhorn beetles) and related families in the superfamily Chrysomeloidea are important components of forest ecosystems and play a key role in nutrient cycling and pollination. Using full mitochondrial genomes and dense taxon sampling, the phylogeny of Chrysomeloidea with a focus on Cerambycidae and allied families was explored. We used 151 mitochondrial genomes (75 newly sequenced) covering all families and 29 subfamilies of Chrysomeloidea. Our results reveal that (i) Chrysomelidae (leaf beetles) are sister to all other chrysomeloid families; (ii) Cerambycidae sensu stricto (s. s.) is polyphyletic due to the inclusion of other families that split Cerambycidae into a ‘lamiine’ clade comprising Lepturinae sensu lato (s. l.) + (Lamiinae + Spondylidinae) and a ‘cerambycine’ clade comprising Dorcasominae + (Cerambycinae + Prioninae s. l.); (iii) the subfamilies within the two clades of Cerambycidae s. s. were monophyletic, except for the placement of Necydalinae nested in Lepturinae, and the placement of Parandrinae within Prioninae (now considered as tribes Necydalini and Parandrini, respectively); (iv) smaller families were grouped into two major clades: one composed of Disteniidae+Vesperidae and the other composed of Orsodacnidae + (Megalopodidae + Oxypeltidae); (v) relationships among the four major clades were poorly supported but were resolved as ((cerambycines + (Disteniidae + Vesperidae) + Orsodacnidae + (Megalopodidae + Oxypeltidae)) + lamiines. Divergence time analyses estimated that Chrysomeloidea originated ca. 154.1 Mya during the late Jurassic, and most subfamilies of Cerambycidae originated much earlier than subfamilies of Chrysomelidae. The diversification of families within Chrysomeloidea was largely coincident with the radiation of angiosperms during the Early Cretaceous.
Does private aid follow the flag? An empirical analysis of humanitarian assistance
Authors: Fuchs Andreas , Öhler Hannes 
Published: August 2020

AbstractThis paper compares the allocation of private humanitarian aid to that of official humanitarian aid awarded to 140 recipient countries over the 2000–2016 period. We construct a new database that offers information on the country in which the headquarters of private donors are located to test whether private aid tends to follow the humanitarian aid allocation pattern of the respective official donor. Our empirical results confirm that private humanitarian aid tends to “follow the flag”. This finding is robust against the inclusion of various fixed effects, estimating instrumental variables models and disaggregating private humanitarian aid into corporate aid and NGO aid. Donor country‐specific estimations reveal that private humanitarian aid from China, Sweden, the United Kingdom and the United States tend to “follow the flag”.
Cable Angle and Minimum Resultant Force Response Analysis of Lower Limb Traction Device for Rehabilitation Robot With Interval Parameters
Authors: Li Yuan , Zi Bin , Zhou Bin , Zhao Ping , Ge Q.J. 
Published: August 2020

Abstract
This paper proposes a hybrid uncertainty analysis method (HUAM) based on the first-order interval perturbation method (FIPM) and Monte Carlo method (MCM) for minimum resultant force response analysis of the lower limb traction device (LLTD) of a hybrid-driven parallel waist rehabilitation robot (HDPWRR) with interval parameters. Based on the analysis of cable angles by using the interval algorithm, the problem of non-uniqueness of the force solution in redundant constraint mechanisms is solved. The force response domain prediction with interval parameters on rehabilitation patients is estimated by using the HUAM which combining the first-order interval perturbation technique with direct Monte Carlo method in different stages, and it reduces the calculation amount. First, the kinematic and static models of the LLTD with deterministic information are established according to its work principle. Then, the interval matrices with interval parameters are calculated by using the FIPM and the response of cable angles is combined with the static model. Third, by numerical examples, the accuracy and efficiency of the HUAM for solving the force response domain problem with interval parameters are verified. The bounds of cable angle response domain of the interval LLTD model are determined. Finally, the minimum resultant force response domain prediction with interval parameters on rehabilitation patients is estimated by combining the FIPM and MCM.
Assisted Spatial Sit-to-Stand Prediction-Part 1: Virtual Healthy Elderly Individuals
Authors: Yang James , Ozsoy Burak 
Published: August 2020

AbstractSit-to-stand (STS) motion is a key determinant of functional independence for the senior people. This paper extends a predictive dynamics formulation previously reported to predict the assisted STS motion, i.e., the motion with a mechanical assistance, unilateral grab-rail bar which is placed on the right side of the virtual-individuals with a vertical orientation. The formulation is able to predict kinetics and kinematics not only in the sagittal plane, but also in frontal and transverse planes. Two different objective functions are tested: The first one is the dynamic effort and the second one is the dynamic effort plus the difference between right and left side support reaction forces (SRFs). Results show that sagittal plane kinematics and kinetics are not affected by the introduction of the grab-rail bar, whereas some significant differences are seen in the medial/lateral and anterior/posterior components of kinematics and kinetics. The healthy elderly group places a priority to the stability during an assisted STS task. The placement of the grab-rail bar on the right side results in a significant decrease in the left knee joint torque. Results in this study are consistent with those reported from the literature.
Image-Based Feedback Control for a Coaxial Spray
Authors: Bothell Julie K. , Morgan Timothy B. , Heindel Theodore J. 
Published: August 2020

Abstract
Optimization of jet engine sprays has the potential to improve efficiency and reduce environmental impact. Sprays can be continually optimized in multivariate scenarios using real-time feedback control, but a method of controlling the sprays based on physical properties must first be established. In this study, a spray controller was developed to optimize the spray angle obtained from shadowgraphs, with the assumption that the largest angle is desired. The spray angle was used as an example, as it is a physically important parameter which is easily found through shadowgraph imaging. Varying ratios of swirled air to straight air, determined by the image-based feedback controller were introduced into the air portion of a coaxial airblast nozzle while keeping the total air flow rate constant. A golden section search converged on the swirled air ratio that provided the largest angle and was validated from the distribution of spray angle versus swirled air ratio. The ratio that produced a spray with the greatest angle of 25.8 ± 2 deg was found at a swirled air ratio of 0.66 ± 0.03 for a spray with a momentum ratio of 6. The successful design and implementation of this image-based feedback controller is intended to provide a foundation for developing real-time active feedback controllers for sprays.
Value of Crystal Vue technique in detecting the placenta accreta spectrum located in c-section scar area
Authors: Chen Shaoqi , Chen Qingzi , Du Xiya , Chen Sumin , Li Weiping , Chen Shigao 
Published: August 2020

Aims: Excessive placental invasion is a life-threatening obstetric disease. Determining the extent of placental villi invasion prenatally is crucial for formulating a surgical plan for pregnant women. The objective of this study was to explore the diagnostic accuracy of the Crystal Vue technique combined with two-dimensional (2D) ultrasound in detecting the degree of placenta accreta spectrum (PAS) located in the C-section scar area.Materials and methods: Twenty-seven pregnant women with a strong suspicion of PAS underwent 2D ultrasound combined with a Crystal Vue examination. The diagnosis of 2D ultrasound alone and Crystal Vue combined with 2D ultrasound was statistically calculated, respectively. Cohen’s kappa (k) was used to measure the consistency between these two ultrasound diagnosis and the postoperative diagnosis.Results: The postoperative diagnosis of 27 pregnant women was as follows: 6 cases of placental accreta, 11 cases of placental increta, 2 cases of placental percreta, 2 cases of placental accrete and placental increta, 2 cases of placental accreta and placental percreta, and 4 cases without PAS. Compared with the postoperative diagnosis, 20 cases (74.07%) were correctly diagnosed by 2D ultrasound alone, 6 cases were misdiagnosed, and one case the diagnosis was incomplete, which were substantially consistent with the postoperative diagnosis (k=0.612, p<0.01). Twenty-six cases (96.30%) were correctly diagnosed by Crystal Vue combined with 2D ultrasound; only one case was incomplete diagnosed which was almost perfectly consistent with the postoperative diagnosis (k=0.934, p<0.01).Conclusions: Combining the Crystal Vue technique with 2D ultrasound can improve the diagnostic accuracy of ultrasound for detecting all types of PAS located in C-section scar area.
Does “Sitting” Stand Alone? A Brief Report Evaluating the Effects of Prenatal Sedentary Time on Maternal and Newborn Anthropometric Outcomes
Authors: Nagpal Taniya S. , Everest Catherine , Souza Sara C.S. , da Silva Danilo F. , Mohammad Shuhiba , Bhattacharjee Jayonta , Adamo Kristi B. 
Published: August 2020

Background: Research on sedentary behavior and effects on maternal and newborn outcomes has been inconclusive. The objective of this report was to correlate sedentary time with maternal and fetal anthropometric measurements and compare the effect on sedentary time based on meeting prenatal activity guidelines. Methods: Healthy pregnant women (N = 61) in their second trimester (24–28 wk gestation) provided 7-day accelerometry data. Outcomes, including neonatal weight, length, and body fat percentage, were collected 24 to 48 hours after delivery. Placenta weight was measured immediately after delivery. Gestational weight gain was calculated by subtracting self-reported prepregnancy weight from measured weight at 38 weeks gestation. Correlations between sedentary time and outcomes were tested with Spearman and Pearson coefficient of correlations in all women separately and in accordance with the 2019 Canadian prenatal exercise guidelines. Results: No significant associations were found between sedentary time and the selected outcomes, even when compared by prenatal exercise level. There was no difference in total time spent sedentary between active (576.7 [52.8] min) and inactive women (599.3 [51.6] min). Conclusions: Meeting exercise recommendations during pregnancy does not significantly decrease total sedentary time. Future studies should aim to evaluate the health effects of both decreasing sedentary time and meeting prenatal exercise guidelines.
Building social cohesion between Christians and Muslims through soccer in post-ISIS Iraq
Authors: Mousa Salma 
Published: August 2020

Social contact and reconciliation
It has been theorized that positive intergroup relations can reduce prejudice and facilitate peace. However, supporting empirical evidence is weak, particularly in the context of real-world conflict. Mousa randomized Christian Iraqi refugees to soccer teams that were composed of either all Christian players or a mixture of Christian and Muslim players (see the Perspective by Paluck and Clark). Playing on the same team as Muslims had positive effects on Christian players' attitudes and behaviors toward Muslims within the context of soccer, but these effects did not generalize to non-soccer contexts. These findings have implications for the potential benefits and limits of positive intergroup contact for achieving peace between groups.

Science
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Chronic hospital nurse understaffing meets COVID-19: an observational study
Authors: Lasater Karen B , Aiken Linda H , Sloane Douglas M , French Rachel , Martin Brendan , Reneau Kyrani , Alexander Maryann , McHugh Matthew D 
Published: August 2020

IntroductionEfforts to enact nurse staffing legislation often lack timely, local evidence about how specific policies could directly impact the public’s health. Despite numerous studies indicating better staffing is associated with more favourable patient outcomes, only one US state (California) sets patient-to-nurse staffing standards. To inform staffing legislation actively under consideration in two other US states (New York, Illinois), we sought to determine whether staffing varies across hospitals and the consequences for patient outcomes. Coincidentally, data collection occurred just prior to the COVID-19 outbreak; thus, these data also provide a real-time example of the public health implications of chronic hospital nurse understaffing.MethodsSurvey data from nurses and patients in 254 hospitals in New York and Illinois between December 2019 and February 2020 document associations of nurse staffing with care quality, patient experiences and nurse burnout.ResultsMean staffing in medical-surgical units varied from 3.3 to 9.7 patients per nurse, with the worst mean staffing in New York City. Over half the nurses in both states experienced high burnout. Half gave their hospitals unfavourable safety grades and two-thirds would not definitely recommend their hospitals. One-third of patients rated their hospitals less than excellent and would not definitely recommend it to others. After adjusting for confounding factors, each additional patient per nurse increased odds of nurses and per cent of patients giving unfavourable reports; ORs ranged from 1.15 to 1.52 for nurses on medical-surgical units and from 1.32 to 3.63 for nurses on intensive care units.ConclusionsHospital nurses were burned out and working in understaffed conditions in the weeks prior to the first wave of COVID-19 cases, posing risks to the public’s health. Such risks could be addressed by safe nurse staffing policies currently under consideration.
British Thoracic Society Quality Standards for outpatient management of pulmonary embolism
Authors: Condliffe Robin , Albert Paul , Alikhan Raza , Gee Emma , Horner Daniel , Hunter Laura , Jacobs Phillip , Limbrey Rachel , Newnham Michael , Preston Wendy , Patel Sheena , Smith Laura-Jane , Suntharalingam Jay 
Published: August 2020

IntroductionThe purpose of the quality standards document is to provide healthcare professionals, commissioners, service providers and patients with a guide to standards of care that should be met for outpatient management of pulmonary embolism in the UK, together with measurable markers of good practice. Quality statements are based on the British Thoracic Society (BTS) Guideline for the Initial Outpatient Management of Pulmonary Embolism.MethodsDevelopment of BTS Quality Standards follows the BTS process of quality standard production based on the National Institute for Health and Care Excellence process manual for the development of quality standards.ResultsSix quality statements have been developed, each describing a standard of care for the outpatient management of pulmonary embolism in the UK, together with measurable markers of good practice.DiscussionBTS Quality Standards for Outpatient Management of Pulmonary Embolism form a key part of the range of supporting materials that the society produces to assist in the dissemination and implementation of a guideline’s recommendations.
Complication rate of ultrasound-guided paravertebral block for breast surgery
Authors: Niesen Adam D , Jacob Adam K , Law Luke A , Sviggum Hans P , Johnson Rebecca L 
Published: August 2020

Background and objectives
Thoracic paravertebral blockade is often used as an anesthetic and/or analgesic technique for breast surgery. With ultrasound guidance, the rate of complications is speculated to be lower than when using landmark-based techniques. This investigation aimed to quantify the incidence of pleural puncture and pneumothorax following non-continuous ultrasound-guided thoracic paravertebral blockade for breast surgery.

Methods
Patients who received thoracic paravertebral blockade for breast surgery were identified by retrospective query of our institution’s electronic database over a 5-year period. Data collected included patient demographics, level of block, type and volume of local anesthetic, occurrence of pleural puncture, occurrence of pneumothorax, evidence of local anesthetic toxicity, and patient vital signs. The incidence of block complications, including pleural puncture, pneumothorax, and local anesthetic toxicity, were ascertained.

Results
529 patients underwent 2163 thoracic paravertebral injections. Zero pleural punctures were identified during block performance; however, two patients were found to have a pneumothorax on postoperative chest X-ray (3.6 per 1000 surgeries, 95% CI 0.5 to 13.6; 0.9 per 1000 levels blocked, 95% CI 0.1 to 3.3). There were no cases of local anesthetic systemic toxicity or associated lipid emulsion therapy administration.

Conclusions
Pneumothorax following non-continuous ultrasound-guided thoracic paravertebral block using a parasagittal approach is an uncommon occurrence, with a similar rate to pneumothorax following breast surgery alone.
QCD sum rule studies on the $$s s {\bar{s}} {\bar{s}}$$ tetraquark states of $$J^{PC} = 0^{-+}$$
Authors: Dong Rui-Rui , Su Niu , Chen Hua-Xing , Cui Er-Liang , Zhou Zhi-Yong 
Published: August 2020

AbstractWe apply the method of QCD sum rules to study the $$s s {\bar{s}} {\bar{s}}$$sss¯s¯ tetraquark states of $$J^{PC} = 0^{-+}$$JPC=0-+. We construct all the relevant $$s s {\bar{s}} {\bar{s}}$$sss¯s¯ tetraquark currents, and find that there are only two independent ones. We use them to further construct two weakly-correlated mixed currents. One of them leads to reliable QCD sum rule results and the mass is extracted to be $$2.51^{+0.15}_{-0.12}$$2.51-0.12+0.15 GeV, suggesting that the X(2370) or the X(2500) can be explained as the $$ss{\bar{s}}{\bar{s}}$$sss¯s¯ tetraquark state of $$J^{PC} = 0^{-+}$$JPC=0-+. To verify this interpretation, we propose to further study the $$\pi \pi /K {\bar{K}}$$ππ/KK¯ invariant mass spectra of the $$J/\psi \rightarrow \gamma \pi \pi \eta ^\prime /\gamma K {\bar{K}} \eta ^\prime $$J/ψ→γππη′/γKK¯η′ decays in BESIII to examine whether there exists the $$f_0(980)$$f0(980) resonance.
Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Authors: Voli Florida , Valli Emanuele , Lerra Luigi , Kimpton Kathleen , Saletta Federica , Giorgi Federico M. , Mercatelli Daniele , Rouaen Jourdin R.C. , Shen Sylvie , Murray Jayne E. , Ahmed-Cox Aria , Cirillo Giuseppe , Mayoh Chelsea , Beavis Paul A. , Haber Michelle , Trapani Joseph A. , Kavallaris Maria , Vittorio Orazio 
Published: August 2020

Abstract

Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed death ligand 1 (PD-L1) signaling have radically improved clinical outcomes in cancer. However, the regulation of PD-L1 expression on tumor cells is still poorly understood. Here we show that intratumoral copper levels influence PD-L1 expression in cancer cells. Deep analysis of the The Cancer Genome Atlas database and tissue microarrays showed strong correlation between the major copper influx transporter copper transporter 1 (CTR-1) and PD-L1 expression across many cancers but not in corresponding normal tissues. Copper supplementation enhanced PD-L1 expression at mRNA and protein levels in cancer cells and RNA sequencing revealed that copper regulates key signaling pathways mediating PD-L1–driven cancer immune evasion. Conversely, copper chelators inhibited phosphorylation of STAT3 and EGFR and promoted ubiquitin-mediated degradation of PD-L1. Copper-chelating drugs also significantly increased the number of tumor-infiltrating CD8+ T and natural killer cells, slowed tumor growth, and improved mouse survival. Overall, this study reveals an important role for copper in regulating PD-L1 and suggests that anticancer immunotherapy might be enhanced by pharmacologically reducing intratumor copper levels.

Significance:
These findings characterize the role of copper in modulating PD-L1 expression and contributing to cancer immune evasion, highlighting the potential for repurposing copper chelators as enhancers of antitumor immunity.
Immune Activation in Patients with Locally Advanced Cervical Cancer Treated with Ipilimumab Following Definitive Chemoradiation (GOG-9929)
Authors: Da Silva Diane M. , Enserro Danielle M. , Mayadev Jyoti S. , Skeate Joseph G. , Matsuo Koji , Pham Huyen Q. , Lankes Heather A. , Moxley Katherine M. , Ghamande Sharad A. , Lin Yvonne G. , Schilder Russell J. , Birrer Michael J. , Kast W. Martin 
Published: August 2020

AbstractPurpose:A phase I clinical trial (GOG-9929) examined the safety and efficacy of adjuvant immune-modulation therapy with the checkpoint inhibitor ipilimumab [anti–CTL antigen-4 (anti–CTLA-4)] following chemoradiation therapy (CRT) for newly diagnosed node-positive human papillomavirus (HPV)-related cervical cancer. To better understand the mechanism of action and to identify predictive biomarkers, immunologic and viral correlates were assessed before, during, and after treatment.Patients and Methods:Twenty-one patients who received CRT and ≥2 doses of ipilimumab and 5 patients who received CRT only were evaluable for translational endpoints. Circulating T-cell subsets were evaluated by multiparameter flow cytometry. Cytokines were evaluated by multiplex ELISA. HPV-specific T cells were evaluated in a subset of patients by IFNγ ELISpot.Results:Expression of the activation markers ICOS and PD-1 significantly increased on T-cell subsets following CRT and were sustained or increased following ipilimumab treatment. Combined CRT/ipilimumab treatment resulted in a significant expansion of both central and effector memory T-cell populations. Genotype-specific E6/E7-specific T-cell responses increased post-CRT in 1 of 8 HPV16+ patients and in 2 of 3 HPV18+ patients. Elevation in levels of tumor-promoting circulating cytokines (TNFα, IL6, IL8) post-CRT was significantly associated with worse progression-free survival.Conclusions:Our data indicate that CRT alone and combined with ipilimumab immunotherapy show immune-modulating activity in women with locally advanced cervical cancer and may be a promising therapeutic option for the enhancement of antitumor immune cell function after primary CRT for this population at high risk for recurrence and metastasis. Several key immune biomarkers were identified that were associated with clinical response.