bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiplicity of positive solutions for Hadamard fractional differential equations with p-Laplacian operator
Authors: Rao Sabbavarapu Nageswara , Singh Manoj , Meetei M. Zico 
Published: March 2020

AbstractIn this paper, we investigate the multiplicity results of some positive solutions for a system of Hadamard fractional differential equations with parameters and p-Laplacian operator subject to three-point boundary conditions which contains fractional derivatives. The proofs of our main result, multiplicity of positive solutions, are derived in terms of different values of parameters by using Guo–Krasnosel’skii’s fixed point theorem.
RETRACTED ARTICLE: Dietary garcinol supplementation improves diarrhea and intestinal barrier function associated with its modulation of gut microbiota in weaned piglets
Authors: Wang Tongxin , Yao Weilei , Li Juan , Shao Yafei , He Qiongyu , Xia Jun , Huang Feiruo 
Published: March 2020

Abstract
Background
The effects of dietary garcinol on diarrhea and intestinal barrier function associated with its modulation of gut microbiota in weaned piglets were investigated.

Method
One hundred forty four weaned piglets (Duroc × Yorkshire × Landrace) from 16 pens (9 piglets per pen) were randomly divided into four treatment groups: controls (CON) or those supplemented with 200 mg/kg (LOW), 400 mg/kg (MID), or 600 mg/kg (HIGH) diet garcinol. After 14-day trial, three piglets per pen were chosen to collect plasma, intestinal tissue and colonic digesta samples.

Results
We demonstrated for the first time that garcinol promoted growth performance, as increased average daily feed intake (ADFI) and decreased feed/gain ratio (F/G); and reduced diarrhea incidence (P < 0.05); and strengthened antioxidant capacity, as an increased antioxidative index (P < 0.05). Additionally, garcinol ameliorated intestinal barrier dysfunction, as an increased villus height to crypt depth ratio, increased zonula occludens protein 1 (ZO-1), occludin and claudin-1 expression in the jejunum and ileum (P < 0.05), and decreased intestinal permeability (P < 0.05); and reduced inflammation, as decreased cytokine interleukin (IL)-6, IL-10, IL-1β and tumor necrosis factor-α (TNF-α) levels in the mucosa of the jejunum and ileum, and NF-κB p65 translocation (P < 0.05). Moreover, garcinol inhibited the growth of most harmful bacteria in the gut, especially Escherichia coli, and increased the growth of the beneficial bacteria Lactobacillus.

Conclusion
This work provides a fundamental basis for the future development of garcinol-functional food use for improving diarrhea and intestinal barrier function in weaned piglets and for understanding the biological effects of garcinol and its potential as a functional feed additive.
Prevalence and incidence of nodding syndrome and other forms of epilepsy in onchocerciasis-endemic areas in northern Uganda after the implementation of onchocerciasis control measures
Authors: Gumisiriza Nolbert , Mubiru Frank , Siewe Fodjo Joseph Nelson , Mbonye Kayitale Martin , Hotterbeekx An , Idro Richard , Makumbi Issa , Lakwo Tom , Opar Bernard , Kaducu Joice , Wamala Joseph Francis , Colebunders Robert 
Published: March 2020

Abstract
Background
Around 2007, a nodding syndrome (NS) epidemic appeared in onchocerciasis-endemic districts of northern Uganda, where ivermectin mass distribution had never been implemented. This study evaluated the effect of community-directed treatment with ivermectin (CDTI) and ground larviciding of rivers initiated after 2009 and 2012 respectively, on the epidemiology of NS and other forms of epilepsy (OFE) in some districts of northern Uganda.

Methods
In 2012, a population-based community survey of NS/epilepsy was carried out by the Ugandan Ministry of Health in Kitgum and Pader districts. In August 2017, we conducted a new survey in selected villages of these districts and compared our findings with the 2012 data. In addition, two villages in Moyo district (where CDTI was ongoing since 1993) served as comparative onchocerciasis-endemic sites in which larviciding had never been implemented. The comparison between 2012 and 2017 prevalence and cumulative incidence were done using the Fisher’s and Pearson’s Chi-square tests at 95% level of significance.

Results
A total of 2138 individuals in 390 households were interviewed. In the selected villages of Kitgum and Pader, there was no significant decrease in prevalence of NS and OFE between 2012 and 2017. However, the cumulative incidence of all forms of epilepsy decreased from 1165 to 130 per 100 000 persons per year (P = 0.002); that of NS decreased from 490 to 43 per 100 000 persons per year (P = 0.037); and for OFE from 675 to 87 per 100 000 persons per year (P = 0.024). The median age of affected persons (NS and OFE) shifted from 13.5 (IQR: 11.0–15.0) years in 2012 to 18.0 (IQR: 15.0–20.3) years in 2017; P <  0.001. The age-standardized prevalence of OFE in Moyo in 2017 was 4.6%, similar to 4.5% in Kitgum and Pader.

Conclusions
Our findings support the growing evidence of a relationship between infection by Onchocerca volvulus and some types of childhood epilepsy, and suggest that a combination of bi-annual mass distribution of ivermectin and ground larviciding of rivers is an effective strategy to prevent NS and OFE in onchocerciasis-hyperendemic areas.
Defervescent dengue patients might be a potential source of infection for vector mosquitoes
Authors: Xu Ye , Zhao Ling-Zhai , Xu Ya-Zhou , Gu Jin-Bao , Wu Kun , Peng Zhi-Qiang , Zhou Xiao-Hong , Zhang Fu-Chun , Chen Xiao-Guang 
Published: March 2020

Abstract
Background
Dengue is a re-emerging public health problem and mosquito-borne infectious disease that is transmitted mainly by Aedes aegypti and Ae. albopictus. Early diagnosis, isolation, and treatment of patients are critical steps for dengue epidemic control, especially to prevent secondary transmission of dengue virus (DENV). However, little is known about defervescent dengue patients as a source of infection.

Methods
This case study describes 1268 dengue patients hospitalized at Guangzhou Eighth People’s Hospital from June 2013 to December 2014. The viral loads of each individual were measured using real-time reverse transcription-polymerase chain reaction. Ae. aegypti and Ae. albopictus were exposed to blood meal with gradated dengue viral loads to characterize the relationship between viremia in dengue patients and the vector competence of vector mosquitoes.

Results
The viral numbers in the blood were measured, ranging from 108 to 103 copies/ml from day 1 to day 12 after fever onset. Vector competence analysis of Ae. aegypti and Ae. albopictus indicated that viremia > 104 copies/ml can still infect vector mosquitoes, which implied that the defervescent dengue patients might be a source of infection.

Conclusions
The results of this study indicate that some defervescent dengue patients still have sufficient viral load to infect vector mosquitoes. Therefore, the protection against mosquito biting for these people should be extended to prevent secondary transmission events.
Contrasting resistance patterns to type I and II pyrethroids in two major arbovirus vectors Aedes aegypti and Aedes albopictus in the Republic of the Congo, Central Africa
Authors: Kamgang Basile , Wilson-Bahun Theodel A. , Yougang Aurelie P. , Lenga Arsene , Wondji Charles S. 
Published: March 2020

Abstract
Background
In the Republic of Congo, with two massive outbreaks of chikungunya observed this decade, little is known about the insecticide resistance profile of the two major arbovirus vectors Aedes aegypti and Aedes albopictus. Here, we established the resistance profile of both species to insecticides and explored the resistance mechanisms to help Congo to better prepare for future outbreaks.

Methods
Immature stages of Ae. aegypti and Ae. albopictus were sampled in May 2017 in eight cities of the Republic of the Congo and reared to adult stage. Larval and adult bioassays, and synergist (piperonyl butoxide [PBO]) assays were carried out according to WHO guidelines. F1534C mutation was genotyped in field collected adults in both species and the polymorphism of the sodium channel gene assessed in Ae. aegypti.

Results
All tested populations were susceptible to temephos after larval bioassays. A high resistance level was observed to 4% DDT in both species countrywide (21.9–88.3% mortality). All but one population (Ae. aegypti from Ngo) exhibited resistance to type I pyrethroid, permethrin, but showed a full susceptibility to type II pyrethroid (deltamethrin) in almost all locations. Resistance was also reported to 1% propoxur in Ae. aegypti likewise in two Ae. albopictus populations (Owando and Ouesso), and the remaining were fully susceptible. All populations of both species were fully susceptible to 1% fenitrothion. A full recovery of susceptibility was observed in Ae. aegypti and Ae. albopictus when pre-exposed to PBO and then to propoxur and permethrin respectively. The F1534C kdr mutation was not detected in either species. The high genetic variability of the portion of sodium channel spanning the F1534C in Ae. aegypti further supported that knockdown resistance probably play no role in the permethrin resistance.

Conclusions
Our study showed that both Aedes species were susceptible to organophosphates (temephos and fenitrothion), while for other insecticide classes tested the profile of resistance vary according to the population origin. These findings could help to implement better and efficient strategies to control these species in the Congo in the advent of future arbovirus outbreaks.
The fight against lymphatic filariasis: perceptions of community drug distributors during mass drug administration in coastal Kenya
Authors: Kusi Caroline , Steinmann Peter , Merten Sonja 
Published: March 2020

Abstract
Background
Lymphatic filariasis (LF), a neglected tropical disease (NTD) and leading cause of global disability, is endemic in 32 countries in Africa with almost 350 million people requiring regular drug administration, and only 16 countries achieving target coverage. Community Drug Distributors (CDDs) are critical for the success of NTD programs, and the distribution of medicines during mass drug administration (MDA) in Africa; however they could also be a weak link. The primary aim of this study is to explore and describe perceptions of CDDs during MDA for LF in Mvita sub-county in Mombasa county and Kaloleni sub-county in Kilifi county, Kenya; and provide recommendations for the effective engagement of communities and CDDs in low-resource settings.

Methods
In September 2018, we conducted six focus group discussions with community members in each sub-county, three with men aged 18–30, 31–50, and 51 years and above and three with women stratified into the same age groups. In each sub-county, we also conducted semi-structured interviews with nine community health extension workers (CHEWs), the national LF focal point, the county NTD focal points, and seven community leaders. Content analysis of the data was conducted, involving a process of reading, coding, and displaying data in order to develop a codebook.

Results
We found that several barriers and facilitators impact the engagement between CDDs and community members during MDA. These barriers include poor communication and trust between CDDs and communities; community distrust of the federal government; low community knowledge and perceived risk of LF, poor timing of MDA, fragmented supervision of CDDs during MDA; and CDD bias when distributing medicines. We also found that CDD motivation was a critical factor in their ability to successfully meet MDA targets. It was acknowledged that directly observed treatment and adequate health education were often not executed by CDDs. The involvement of community leaders as informal supervisors of CDDs and community members improves MDA.

Conclusions
In order to achieve global targets around the elimination of LF, CDDs and communities must be effectively engaged by improving planning and implementation of MDA.
Responses of fitness center employees to cases of suspected eating disorders or excessive exercise
Authors: Colledge Flora , Cody Robyn , Pühse Uwe , Gerber Markus 
Published: March 2020

Abstract
Background
While exercise and physical activity are important parts of a healthy life, there is evidence that some individuals exercise to a degree which may jeopardize their health. These individuals may in some cases be exercising to lose weight or compensate binge eating episodes as part of an eating disorder. Others may experience an addiction-like relationship with exercise. Fitness center employees are ideally placed to observe these forms of unhealthy behavior, and are responsible for ensuring that clients do not put themselves at undue risk; however, to date, no study has addressed both eating disorders and excessive exercise. Therefore, the aim of our study is to determine whether these employees report incidences of these issues, and if they believe they can differentiate between them.

Methods
One-hundred-and-forty fitness centers in the German-speaking regions of Switzerland were contacted. Of these, 99 employees (60 men, 39 women, Mage = 33.33 years, SD = 12.02) responded to an online questionnaire. The questionnaire briefly described the two issues of interest (eating disorders and excessive exercise), and then invited respondents to complete a number of questions detailing whether they had experience with these issues, and how they dealt with them.

Results
Approximately 75% of the employees had suspected a client of having an eating disorder or exercising excessively, and 65% of these respondents confronted the client at least once. Interestingly, respondents reported clearly that they felt able to differentiate between the two types of disorder. Older respondents were significantly more likely to have suspicions and act on them. However, less than half of the respondents were aware of guidelines addressing this issue, and the majority desired more information about how to identify and address both disorders.

Conclusions
Swiss fitness center employees frequently encounter individuals who they suspect of exercising excessively, or suffering from an eating disorder. While they often confront these individuals, they would like more detailed information about how to manage this process. Given that both disorders can potentially lead to severe health consequences, a detailed description of symptoms, management techniques and resources should be a feature in all Swiss fitness center guidelines.
Role of child maltreatment and gender for bipolar symptoms in young adults
Authors: Haussleiter Ida S. , Neumann Eva , Lorek Sandra , Ueberberg Bianca , Juckel Georg 
Published: March 2020

Abstract
Background
Child maltreatment has been shown to be associated with a wide range of mental disorders, including bipolar disorders. In this 2-year follow-up study, recollections of emotional, physical and sexual abuse were related to bipolar symptoms, namely depressive, hypomanic and manic symptoms.

Methods
The sample consists of 134 students who took part at five measurement times within the 2-year period. Data were collected with self-report scales.

Results
The results show that recollections of abuse, particularly emotional abuse, were associated with more severe depressive symptoms; this finding, however, only applied to women. Hypomanic and manic symptoms were not associated with recollections of abuse. For hypomanic symptoms, however, a significant decrease over the 2 years was observed.

Conclusions
The findings of this study suggest that recollections of abusive experiences in childhood combined with female gender increase the risk for depression, whereas hypomanic and manic states are probably better predicted by other factors, such as current life circumstances.
Silicified bulliform cells of Poaceae: morphological characteristics that distinguish subfamilies
Authors: Chen Iju , Li Kuang-ti , Tsang Cheng-hwa 
Published: March 2020

Abstract
Background
Grass phytoliths are the most common phytoliths in sediments; recognizing grass phytolith types is important when using phytoliths as a tool to reconstruct paleoenvironments. Grass bulliform cells may be silicified to large size parallelepipedal or cuneiform shaped phytoliths, which were often regarded as of no taxonomic value. However, studies in eastern Asia had identified several forms of grass bulliform phytoliths, including rice bulliform phytolith, a phytolith type frequently used to track the history of rice domestication. Identification with a higher level of taxonomic resolution is possible, yet a systematic investigation on morphology of Poaceae bulliform phytoliths is lacking. We aimed at providing a morphological description of bulliform phytoliths of Poaceae from Taiwan based on morphometric measurements in anatomical aspect. The results are important references for paleo-ecological studies.

Result
The morphology of grass bulliform phytoliths is usually consistent within a subfamily; the end profile is relatively rectangular in Panicoideae and Micrairoideae, whereas cuneiform to nearly circular in Oryzoideae, Bambusoideae, Arundinoideae, and Chloridoideae. Bulliform phytoliths were seldom observed in Pooideae. Certain morphotypes are limited to plants growing in specific environments. For example, large, thin, and pointed bulliform phytoliths are associated with wet habitat; Chloridoideae types are mostly from C4 plants occupying open arid places.

Conclusion
Grass bulliform phytoliths can be identified at least to the subfamily level, and several forms were distinguished within large subfamilies. Previously un-reported silicified cell types, i.e., arm cells and fusoids, and two special trichome phytolith types associated with bulliform phytoliths, were described. Morphometric methods were great tools for delimiting morphotypes; with refined morphological classification the association between forms and habit/habitats was revealed. The knowledge provides new ways to interpret phytolith assemblage data, and it is especially useful when the sediments are enriched in large blocky phytoliths.
Mild traumatic brain injury/concussion and female sexuality, a scoping review of the literature
Authors: Anto-Ocrah Martina , Tiffany Kimberly , Hasman Linda , van Wijngaarden Edwin 
Published: March 2020

Abstract
Background
The American Congress of Rehabilitation Medicine (ACRM) in 2010 called for more head injury research on gender disparities to bridge the gender gap for the short-and long-term effects of TBI, including sexual and reproductive outcomes. In this paper, we review the state of the literature before and after the ACRM announcement, and evaluate how research teams have considered females and mildly injured TBI(mTBI)/concussion groups in post-TBI-related changes in sexual functioning.

Methods
The research question for this scoping review was “what is the state of the literature in the evaluation of post-TBI sexual changes for women, and individuals with mTBI?” Using the 2010 ACRM call for action as a line of demarcation, we compared our findings before and after the 2010 announcement.

Results
We identified 9 research studies that addressed sexual functioning changes in females and mTBI/concussion groups. Four of the nine were published before the 2010 ACRM announcement, and five were published after. The representation of female research participants increased steadily over the 28-year timespan. The proportion of individuals with mTBI included in the post-2010 era was higher than the earlier time period. Consistently, women with mTBI reported more adverse sexual outcomes compared to male cohorts, orthopaedic, and non-injured comparison groups. This observation persisted regardless of recruitment site (rehabilitation center/Emergency Department (ED)/Community) or time of outcome assessment (acute versus chronic). The findings also remained despite the heterogeneity of survey questionnaires used to evaluate sexual functioning outcomes. Excluding the most recent 2019 study, none of the research groups compared the findings by TBI severity, making it difficult to fully understand how concussion-related sexual changes compare to more severe forms of the head injury. The long term impacts of the sexual changes, such as infertility and relationship discord were also absent across all studies; even though most evaluated outcomes chronically (some as far out as 20 years post injury).

Conclusion
The number of publications in the era before the ACRM call for action and afterwards were almost identical. In order to tailor interventions for the appropriate groups of TBI patients, more neurosexuality research is needed to increase awareness of the importance of sexuality as a health outcome for individuals with neurodisabilities.
Significant enhancements of secondary cosmic rays and electric field at the high mountain peak of Lomnický Štít in High Tatras during thunderstorms
Authors: Chum J. , Langer R. , Baše J. , Kollárik M. , Strhárský I. , Diendorfer G. , Rusz J. 
Published: March 2020

AbstractHigh electric fields that occur in thunderstorm clouds in the Earth’s atmosphere might accelerate energetic charged particles produced by cosmic rays. Such energetic particles, especially electrons, can cause additional ionization as they are multiplied and thus form avalanche of relativistic electrons. These relativistic electrons emit Bremsstrahlung in the X- or gamma-ray spectral ranges as they lose their kinetic energy via collisions. Thunderstorm ground enhancements (TGEs) of secondary cosmic ray fluxes recorded at the top of a sharp rocky mountain of Lomnický Štít in High Tatras (2634 m, Slovak Republic) are compared with simultaneous measurements of electric field at the mountain top and on its slope at the observatory of Skalnaté Pleso (1780 m). Results of measurements performed from May to September in 2017 and from May to October in 2018 are presented. The cosmic ray flux is measured by Space Environment Viewing and Analysis Network (SEVAN) and by neutron monitor with 1-s resolution. The TGEs that persisted usually several minutes were mainly detected in the SEVAN channel 1 which has the lowest energy threshold, about 7–8 MeV. A statistical analysis shows that these enhancements usually occurred (not only) during large values of vertical, upward-pointing electric fields measured just above the detector. It is shown that the measurement of electric field at Skalnaté Pleso, distant about 1.86 km from the mountain top is also partly correlated with the enhancements and can provide additional useful information about the distance or dimension of charge structure and dynamics of electric field, especially on short time scales. The enhancements usually did not exceed several tens of percent of background values. However, events that exceeded the background values several times were also recorded. The most extreme event exceeded the background values about 215 times. This event was also detected by other SEVAN channels and by the neutron monitor (~ 130% enhancement), which indicates a possibility of photonuclear reactions. The enhancements were often terminated by a nearby lightning.
Current understanding of substrate specificity and regioselectivity of LPMOs
Authors: Zhou Xiaoli , Zhu Honghui 
Published: March 2020

AbstractRenewable biomass such as cellulose and chitin are the most abundant sustainable sources of energy and materials. However, due to the low degradation efficiency of these recalcitrant substrates by conventional hydrolases, these biomass resources cannot be utilized efficiently. In 2010, the discovery of lytic polysaccharide monooxygenases (LPMOs) led to a major breakthrough. Currently, LPMOs are distributed in 7 families in CAZy database, including AA9–11 and AA13–16, with different species origins, substrate specificity and oxidative regioselectivity. Effective application of LPMOs in the biotransformation of biomass resources needs the elucidation of the molecular basis of their function. Since the discovery of LPMOs, great advances have been made in the study of their substrate specificity and regioselectivity, as well as their structural basis, which will be reviewed below.