bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors for Postprocedural Arterial Ischemic Stroke in Children With Cardiac Disease
Authors: Henzi Bettina C. , Brotschi Barbara , Balmer Christian , Hennig Bert , Rimensberger Peter , Perez Marie-Hélène , Pfammatter Jean-Pierre , Beghetti Maurice , Sekarski Nicole , Datta Alexandre N. , Fluss Joel , Faignart Nicole , Hackenberg Annette , Regényi Mária , Steinlin Maja , Hug Maja I. 
Published: August 2020

Background and Purpose:
Cardiac pathologies are the second most frequent risk factor (RF) in children with arterial ischemic stroke (AIS). This study aimed to analyze RFs for AIS in children with cardiac disease and cardiac intervention.

Methods:
Data were drawn from the Swiss Neuropediatric Stroke Registry. Patients with cardiac disease and postprocedural AIS registered from 2000 until 2015 were analyzed for the cause of cardiac disease and for potential RFs.

Results:
Forty-seven out of 78 children with cardiac disease had a cardiac intervention. Of these, 36 presented a postprocedural AIS. Median time from cardiac intervention to symptom onset was 4 days (interquartile range, 2–8.5); time to diagnosis of AIS was 2 days (interquartile range, 0–5.8). Main RFs for postprocedural AIS were hypotension, prosthetic cardiac material, right-to-left shunt, arrhythmias, low cardiac output, and infections.

Conclusions:
In children with postprocedural AIS, time to diagnosis was delayed. Most patients presented multiple potentially modifiable RFs as hemodynamic alterations and infections.
Symptomatic Intracranial Hemorrhage After Mechanical Thrombectomy in Chinese Ischemic Stroke Patients
Authors: Zhang Xiaohao , Xie Yi , Wang Huaiming , Yang Dong , Jiang Teng , Yuan Kang , Gong Pengyu , Xu Pengfei , Li Yunzi , Chen Jingjing , Wu Min , Sheng Lei , Liu Dezhi , Liu Xinfeng , Xu Gelin 
Published: August 2020

Background and Purpose:
Symptomatic intracranial hemorrhage (sICH), potentially associated with poor prognosis, is a major complication of endovascular thrombectomy (EVT) for ischemic stroke patients. We aimed to develop and validate a risk model for predicting sICH after EVT in Chinese patients due to large-artery occlusions in the anterior circulation.

Methods:
The derivation cohort recruited patients with EVT from the Endovascular Treatment for Acute Anterior Circulation Ischemic Stroke Registry in China. sICH was diagnosed according to the Heidelberg Bleeding Classification within 24 hours of EVT. Stepwise logistic regression was performed to derive the predictive model. The discrimination and calibration of the risk model were assessed using the C index and the calibration plot. An additional cohort of 503 patients from 2 stroke centers was prospectively enrolled to validate the new model.

Results:

We enrolled 629 patients who underwent EVT as the derivation cohort, among whom 87 developed sICH (13.8%). In the multivariate adjustment, Alberta Stroke Program Early CT Score (odds ratio [OR], 0.85;
P
=0.005), baseline glucose (OR, 1.13;
P
=0.001), poor collateral circulation (OR, 3.06;
P
=0.001), passes with retriever (OR, 1.52;
P
=0.001), and onset-to-groin puncture time (OR, 1.79;
P
=0.024) were independent factors of sICH and were incorporated as the Alberta Stroke Program Early CT Score, Baseline Glucose, Poor Collateral Circulation, Passes With Retriever, and Onset-to-Groin Puncture Time (ASIAN) score. The ASIAN score demonstrated good discrimination in the derivation cohort (C index, 0.771 [95% CI, 0.716–0.826]), as well as the validation cohort (C index, 0.758 [95% CI, 0.691–0.825]).

Conclusions:
The ASIAN score reliably predicts the risk of sICH in Chinese ischemic stroke patients treated by EVT.
Cortical Microinfarcts Associated With Worse Outcomes in Patients With Acute Ischemic Stroke Receiving Endovascular Treatment
Authors: Wei Yufei , Pu Yuehua , Pan Yuesong , Nie Ximing , Duan Wanying , Liu Dacheng , Yan Hongyi , Lu Qixuan , Zhang Zhe , Yang Zhonghua , Wen Miao , Gu Weibin , Hou Xinyi , Ma Ning , Leng Xinyi , Miao Zhongrong , Liu Liping , Wang Ning , Chen Shengli , Zhang Meng , Li Wei , Zhang Xu , Ke Kaifu , Niu Xiaoyuan , Sun Bing , Zhang Xin , Du Huishan , Li Hongyan , Wu Jin , Wang Changqing , Xiong Yingqiong , Liu Yong , Yang Jun , Wu Guode , Song Xiaonan 
Published: August 2020

Background and Purpose:
We aimed to evaluate the impact of cortical microinfarcts (CMIs) on functional outcome after endovascular treatment in patients with acute ischemic stroke.

Methods:
In a multicenter registration study for RESCUE-RE (a registration study for Critical Care of Acute Ischemic Stroke After Recanalization), eligible patients with large vessel occlusion stroke receiving endovascular treatment, who had undergone 3T magnetic resonance imaging on admission or within 24 hours after endovascular treatment were analyzed. We evaluated the presence and numbers of CMIs with assessment of axial T1, T2-weighted images, and fluid-attenuated inversion recovery images. The primary outcome was functional dependence or death defined as modified Rankin Scale scores of 3 to 6 at 90 days. Secondary outcomes included early neurological improvement, any intracranial hemorrhage, symptomatic intracranial hemorrhage, and mortality. We investigated the independent associations of CMIs with the outcomes using multivariable logistic regression in overall patients and in subgroups.

Results:

Among 414 patients (enrolled from July 2018 to May 2019) included in the analyses, 96 (23.2%) patients had at least one CMI (maximum 6). Patients with CMI(s) were more likely to be functionally dependent or dead at 90 days, compared with those without (55.2% versus 37.4%;
P
<0.01). In multivariable logistic regression analyses, presence of CMI(s) (adjusted odds ratio, 1.78 [95% CI, 1.04−3.07];
P
=0.04) and multiple CMIs (CMIs ≥2; adjusted odds ratio, 7.41 [95% CI, 2.48−22.17];
P
<0.001) were independently, significantly associated with the primary outcome. There was no significant difference between subgroups in the associations between CMI presence and the primary outcome.

Conclusions:
Acute large vessel occlusion stroke patients receiving endovascular treatment with CMI(s) were more likely to have a poor functional outcome at 90 days, independent of patients’ characteristics. Such associations may be dose-dependent.

Registration:

URL:
http://www.chictr.org.cn
; Unique identifier: ChiCTR1900022154.
<p><strong>A new species of <em>Frullania</em> subg. <em>Frullania</em> (Marchantiophyta) from the Brazilian Amazon</strong></p>
Authors: LIMA ELIENE , ILKIU-BORGES ANNA LUIZA , GRADSTEIN S. ROBBERT 
Published: August 2020

Frullania subg. Frullania (= subg. Thyopsiella) is a little-known group of liverworts in the Neotropics, being represented by only two species. Both are members of the subsect. Microphylla characterized by very small, dioicous plants, ocellate leaves, caducous leaf lobes and very small, distant underleaves. Here we describe and illustrate a third neotropical species in this group, F. amazonica sp. nov., from the Amazon region of Brazil. The new species is readily distinguished from its two allies in the elongate median leaf cells, the very narrow, oblong underleaves with rounded apices and the strongly toothed female bracts and bracteoles. The new name F. section Microphyllae (R.M.Schust.) comb. nov. is proposed and a key is provided to the neotropical members of this section.
<p><strong><em>Ganoderma bambusicola</em></strong><strong> sp. nov. (Polyporales, Basidiomycota) from southern Asia</strong></p>
Authors: WU SHENG-HUA , CHERN CHI-LIANG , WEI CHIA-LING , CHEN YU-PING , AKIBA MITSUTERU , HATTORI TSUTOMU 
Published: August 2020

Ganoderma bambusicola sp. nov. is described and illustrated from tropical Taiwan; it is also found in Laos and Myamar. The species is recognized as new based on morphological study and phylogenetic analyses using three gene regions: ITS, rpb2 and tef1-α. Ganoderma bambusicola has been incorrectly identified as G. neojaponicum in Taiwan for several decades on account of it having a similar shiny dark reddish brown to purplish black pileus surface and a blackish long stipe, but it differs from the latter species in having a homogeneous pileal context. Ganoderma bambusicola is, to date, only known from southern Asia and grows on bamboo roots, while G. neojaponicum occurs on roots or trunks of conifers in Japan, China and Korea. These two species do not have a close relationship according to the present phylogenetic study.
A Comparison of Intra-Annual and Long-Term Trend Scaling of Extreme Precipitation with Temperature in a Large-Ensemble Regional Climate Simulation
Authors: Sun Qiaohong , Zwiers Francis , Zhang Xuebin , Li Guilong 
Published: August 2020

AbstractLong-term changes in extreme daily and subdaily precipitation simulated by climate models are often compared with corresponding temperature changes to estimate the sensitivity of extreme precipitation to warming. Such “trend scaling” rates are difficult to estimate from observations, however, because of limited data availability and high background variability. Intra-annual temperature scaling (here called binning scaling), which relates extreme precipitation to temperature at or near the time of occurrence, has been suggested as a possible substitute for trend scaling. We use a large ensemble simulation of the Canadian regional climate model (CanRCM4) to assess this possibility, considering both daily near-surface air temperature and daily dewpoint temperature as scaling variables. We find that binning curves that are based on precipitation data for the whole year generally look like the composite of binning curves for winter and summer, with the lower temperature portion similar to winter and the higher temperature portion similar to summer, indicating that binning curves reflect seasonal changes in the relationship between temperature and extreme precipitation. The magnitude and spatial pattern of binning and trend scaling rates are also quantitatively different, with little spatial correlation between them, regardless of precipitation duration or choice of temperature variable. The evidence therefore suggests that binning scaling with temperature is not a reliable predictor for future changes in precipitation extremes in the climate simulated by CanRCM4. Nevertheless, external forcing does have a discernable influence on binning curves, which are seen to shift upward and to the right in some regions, consistent with a general increase in extreme precipitation.
Do Lidocaine Patches Reduce Opioid Use in Acute Rib Fractures?
Authors: Johnson Matthew , Strait Lauren , Ata Ashar , Bartscherer Ashley , Miller Claire , Chang Andrew , Stain Steven C. , Tafen Marcel 
Published: August 2020

Background Pain control is an important aspect of rib fracture management. With a rise in multimodal care approaches, we hypothesized that transdermal lidocaine patches reduce opioid utilization in hospitalized patients with acute rib fractures not requiring continuous opioid infusion. Methods We performed a retrospective analysis of adult trauma patients with acute rib fractures admitted to the Trauma Service from January 2011 to October 2018. We compared patients who received transdermal lidocaine patches to those who did not and evaluated cumulative opioid consumption, expressed in morphine milligram equivalents (MMEs). Secondary outcomes included the rate of pulmonary complications and length of hospital stay. Results Of the 21 190 trauma admissions, 3927 (18.5%) had rib fractures. Overall, 1555 patients who received continuous opioid infusion were excluded. Of the remaining 2372 patients, 725 (30.6%) patients received lidocaine patches. The mean total MME of patients who received lidocaine patches was 55.7 MME (30.7 MME on multivariate analysis) and was lower than that of patients who did not receive lidocaine patches ( P ≤ .01). There was no difference in hospital length of stay (no lidocaine patches vs received lidocaine patches: 6.2 days vs 6.5 days, P = .34) or pulmonary complications (1.7% vs 2.8%, P = .08). Discussion In admitted trauma patients with acute rib fractures not requiring continuous intravenous opiates, lidocaine patch use was associated with a significant decrease in opiate utilization during the patients’ hospital course.
Sonographic assessment of femoral cartilage thickness in healthy adults
Authors: Bedewi Mohamed A , Elsifey Ayman A. , Naguib Moheyeldeen F , Saleh Ayman K , Nwihadh Naif Bin , Abd-Elghany Amr A. , Swify Sherine M 
Published: August 2020

Objective This study was performed to obtain normative data of the distal femoral cartilage thickness in healthy adults by ultrasound. Methods This cross-sectional study included 72 healthy adults. The demographic characteristics of the participants were recorded, and the thickness of the femoral articular cartilage was measured using a 5- to 18-MHz linear probe. Results Significant statistical difference towards the male side at left medial condyle (P = 0.001) and left lateral condyle (P = 0.009). Weakly positive statistical difference was noted towards the male side at right medial condyle (P = 0.06) and right lateral condyle (P = 0.07). The femoral cartilage thickness in the study participants did not correlate with weight, body mass index, and age (P >0.05). Positive statistical correlation with height noted in right medial condyle, right lateral condyle, right intercondylar area, and left medial condyle. Conclusion This study increases the pool of normative data of femoral cartilage thickness measurements. Additionally, the findings of this study emphasize the fact that women have thinner cartilage than men in four of the studied parameters.
Duration of contact lens removal before myopic refractive surgery
Authors: Shehadeh-Mashor Raneen , Mimouni Michael , Shapira Yinon , Sela Tzahi , Munzer Gur , Kaiserman Igor 
Published: August 2020

Purpose: To compare refractive surgery outcomes in patients with different periods without contact lenses prior laser surgery. Materials and methods: Patients included in this study underwent myopic keratorefractive laser surgery between January 2005 and December 2014. Patients were divided into three groups based on the duration of time passed free of soft contact lens wearing prior to final preoperative evaluation and surgery (<24 h, 1–3 days or >3 days). Spectacle wearers served as a control group. Postoperative safety index, efficacy index and % of eyes within 0.5 D of the four groups were compared. A general linear model was used to compare main outcomes while adjusting for age, gender, preoperative measurements, and procedure type (LASIK vs PRK). Results: Overall, 19,747 eyes were included. Soft contact lenses were worn by 42.3% (<24 h: 4.8%, 1–3 days: 18.5% and >3 days: 19.0%) and spectacles by 57.7% prior to surgery. In the PRK group, after adjusting for differences in baseline variables, the <24-h group had a significantly lower efficacy index than all the other groups. There were no significant differences between groups in terms of % eyes within ±0.5 D of intended correction ( p = 0.55) or safety index (0.20). In the LASIK group, after adjusting for differences in baseline variables, there were no significant differences between groups in all primary outcomes. Conclusion: Soft contact lenses should be removed at least 24 h prior to final preoperative evaluation and refractive surgery, especially for patients undergoing PRK.
Meta-herpetic ulcer following intravitreal bevacizumab
Authors: Behera Geeta , Gokhale Tanmay , Deb Amit Kumar , Babu Krishna Ramesh 
Published: August 2020

Purpose: To report a case of meta-herpetic ulcer that developed after intravitreal bevacizumab injection. Methods: A 55-year-old man with type 2 diabetes mellitus and nephropathy received intravitreal injection of bevacizumab in his right eye for proliferative diabetic retinopathy with macular edema. Results: Two days after the injection, the patient presented with severe pain, redness, and photophobia, and decreased visual acuity in the right eye. The cornea showed a paracentral epithelial erosion with heaped margins with subepithelial haze and punctate keratopathy, and high intraocular pressure. He initially responded to topical antiviral and antiglaucoma medications. However, it rapidly progressed to a geographic ulcer on initiation of mild steroid and became resistant to conventional medical management. His nephropathy precluded treatment with full dose of systemic antivirals and antiglaucoma drugs. Subsequently, it healed after a paramedian tarsorrhaphy was performed. Conclusion: Herpetic epithelial keratitis following intravitreal bevacizumab is a rare occurence. However, this case is the first report of progression to a meta-herpetic ulcer.
Use of Stainless-Steel, Balloon-Expandable Chimney Grafts Is Durable Though Caution Is Required When Lining Angulated Renal Arteries
Authors: Taneva Gergana T. , Fazzini Stefano , Pipitone Marco Damiano , Karaolanis Georgios , Torsello Giovanni , Bremer Christoph , Austermann Martin , Donas Konstantinos P. 
Published: August 2020

Purpose: To analyze the overall performance of flexible nitinol stents used to line chimney grafts (CGs) during chimney endovascular aneurysm repair (chEVAR) of pararenal pathologies. Materials and Methods: A retrospective review was conducted of all 116 elective patients (mean age 74.3±7.2 years; 103 men) who underwent chEVAR with balloon-expandable Advanta V12/iCAST CGs in combination with the Endurant stent-graft between January 2009 and December 2017 at a single center. CG lining with a nitinol stent was electively performed in 43 target vessels of 32 patients. The Kaplan-Meier method was used to estimate the primary outcomes of CG patency and freedom from reintervention (FFR) at the patient level and according to the use of a stent to line the CG. Estimates are reported with the 95% confidence interval (CI). Adjusted odds ratios (ORs) were calculated to identify any confounding effect between the presence/absence of a stent lining or according to the number of CGs. Results: The mean radiological follow-up was 27.3 months (range 22.1–32.6). During this time, 8 CGs (4.7%) became occluded, 6 of them were lined with stents. Restoration of patency was possible in 3 of the 4 occluded stents that were associated with symptoms. First-year primary patency estimates were 96.9% (95% CI 92.5% to 100%) for the unlined group vs 77.1% (95% CI 58% to 95.3%; p=0.001) for the lined group, while FFR was 87.6% (95% CI 79.9% to 95.2%) vs 83.4% (95% CI 68.1% to 98.6%; p=0.82), respectively. Lining represented an independent risk factor for CG occlusion (OR 9.9, p=0.006). Conclusion: CG lining performed mainly in angulated renal arteries during chEVAR was significantly associated with CG occlusion. These findings highlight the importance of not having the distal part of the CG impinge on the angulated segment of the target vessel.
An open-label randomised pilot trial on safety of wheat variety C273 in patients with adult celiac disease
Authors: Grover Jasmine , Chhuneja Parveen , Midha Vandana , Singh Arshdeep , Mahajan Ramit , Mehta Varun , Verma Ramneek , Bansal Ekta , Deka Dipak , Bansal Namita , Sood Neena , Narang Vikram , Sood Ajit 
Published: August 2020

Background: The only effective treatment for celiac disease (CeD) is gluten free diet (GFD). However, GFD is restrictive and efforts are being made to explore alternative therapies including safer wheat varieties. Wheat variety C273 has been previously identified to have reduced load of intact T-cell stimulatory epitopes via in silico and in vitro analysis. Methods: Adult patients diagnosed with CeD and recovered on GFD were included in the study. Patients were randomised into two groups in a 2:1 ratio. Patients in group I had graded introduction of C273 wheat in diet, maintained for 24 weeks; in Group II, wheat was restricted with continuation of GFD. Clinical symptoms, serology [anti-tissue transglutaminase (anti-tTG), anti-endomysial antibody (anti-EMA)], circulating inflammatory biomarkers [intestinal fatty-acid binding protein (I-FABP), plasma citrulline, interferon-γ (IFN-γ)] and histology were evaluated periodically. Final evaluation was performed at week 28. Results: A total of 15 patients were enrolled (Group I: n = 10, Group II: n = 5). All patients except two in Group I remained compliant. None of the remaining eight patients in group I developed symptoms. No significant changes in serology (anti-tTG, anti-EMA) and histology were observed between the two groups at 28 weeks ( p > 0.05). Significant changes in plasma citrulline(29.87 ± 8.98 versus 36.58 ± 3.09, p = 0.049) and IFN-γ (44.56 ± 9.74 versus 33.50 ± 3.68; p = 0.031) were observed in Group I. Conclusion: Consumption of C273 wheat did not result in development of symptoms or evident changes in serology and histology at 28 weeks. However, variations in circulating inflammatory markers were noted. Larger randomised trials are needed to corroborate these findings. Clinical Trials Registry-India: CTRI/2018/06/014521.
Longitudinal Assessment of Ellipsoid Zone Mapping Parameters in Retinal Venous Occlusive Disease With Associated Macular Edema
Authors: Abraham Joseph R. , Boss Joseph , Babiuch Amy S. , Singh Rishi P. , Srivastava Sunil , Reese Jamie , Ehlers Justis P. 
Published: August 2020

Purpose: This work evaluated the longitudinal dynamics of ellipsoid zone (EZ) integrity in retinal vein occlusion (RVO) with macular edema and their relation to outcomes. Methods: Clinical characteristics and optical coherence tomography data of patients with RVO and associated macular edema were collected at baseline and at 3 and 12 months. Macular cube scans were exported into EZ and retinal-layer analysis software. Longitudinal EZ parameters and visual acuity (VA) outcomes were regressed and correlated. Results: The study included 108 eyes of 108 patients; all eyes were treated with antivascular endothelial growth factor therapy at the baseline visit. VA improved from 20/97 at baseline to 20/52 at 3 months and 12 months ( P < .001), correlating with EZ integrity at each time point ( P < .001). At 12 months following initiation of antivascular endothelial growth factor therapy, EZ partial attenuation and EZ total attenuation improved over 12 months from 16.4% to 8.5% ( P < .001) and from 12.3% to 5.9% ( P < .001), respectively. VA improvement from baseline to 12 months correlated with improvement of EZ partial and total attenuation ( P < .001). Baseline EZ characteristics did not predict VA outcomes, but at 3 months, EZ parameters did predict improvement in visual outcomes by 12 months ( P < .01). Conclusions: EZ and outer retinal integrity are correlated with functional outcomes in RVO. Following treatment, EZ integrity improves and is associated with functional improvement. In RVO baseline, EZ features were not associated with 1-year VA outcomes, but evaluation of EZ integrity at 3 months was linked to 1-year outcomes.