bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ischemic stroke on the background of probable in situ thrombosis of atrial septal aneurysm in a patient taking hormonal contraceptives
Authors: Mekhryakov S. A. , Kulesh A. A. , Syromyatnikova L. I. 
Published: March 2020

Introduction. The independent role of the atrial septal aneurysm in the occurrence of ischemic stroke remains controversial. In addition to the mechanism of paradoxical embolism against the background of a patent foramen ovale associated with an aneurysm, a number of studies have demonstrated that ischemic stroke can develop due to in situ thrombosis in the aneurysm region.Materials and methods. Description of the clinical case of a patient with atrial septal aneurysm and ischemic stroke while taking hormonal contraceptives. Analyzed all available publications in PubMed on this topic.Results and discussion. Among publications suitable for the criteria, in addition to direct visualization of a blood clot in the area of the atrial septal aneurysm, its independent effect on the occurrence of embolic events was demonstrated. In all analyzed cases, anticoagulants were prescribed for secondary prevention, which is justified on the basis of the hypothesis of in situ thrombosis in the aneurysm region.Conclusion. The analysis of scientific publications showed that the knowledge of this problem is still extremely small. There are no clear criteria, in addition to direct visualization of a blood clot, allowing the atrial septal aneurysm to be considered as a direct cause of ischemic stroke. Nevertheless, the presence of this cardiac abnormality and in combination with risk factors or evidence of prothrombotic status make it possible to regard it as an independent cause of stroke, and qualify the stroke as cardioembolic, which justifies the advisability of prescribing anticoagulants for secondary prevention.
Heterogeneity of speech disorders in Parkinson’s disease: potential for classification, diagnostics and therapy
Authors: Vasenina E. E. , Levin O. S. 
Published: March 2020

Introduction. Speech disorders in Parkinson’s disease are a very common clinical sign. The structure of speech disorders is at the moment not fully understood, there is no unified approach to classification, therapy effects have not been studied.Materials and methods: 324 PD patients were primarily included in the study, and from those the patients showing clinically significant speech disorders (22,4%) were selected. All the patients were assessed for motor disorders (UPDRS part 3), cognitive disorders (Addenbrooke’s cognitive examination), as well as affective disorders.Results: by means of cluster analysis we identified 4 subtypes of speech disorders as dysphasia (adynamic, disprosodic, constructive, and logopenic). None of the forms was associated with parkinsonism severity and general severity of cognitive impairment, which allowed to consider dysphasia as a separate clinical syndrome. Disprosodic dysphasia differentiated by severity of axial symptoms (F value = 3.279, p < 0,05), adynamic dysphasia was associated with more pronounced apathy (F value = 4,2, p < 0,01), constructive dysphasia – with impairment of visual-spatial functioning (F value 29,93, p<0,0001), while logopenic dysphasia was associated with more severe attention deficiency.Conclusion: Speech disorders in PD are heterogeneous and can be regarded as manifestations of dysphasia. Identification of various subtypes will allow for optimizing the treatment of PD patients.
Transformation tools enabling the implementation of nature-based solutions for creating a resourceful circular city
Authors: Katsou Evina , Nika Chrysanthi-Elisabeth , Buehler Devi , Marić Bruno , Megyesi Boldizsár , Mino Eric , Babí Almenar Javier , Bas Bilge , Bećirović Dženan , Bokal Sabina , Đolić Maja , Elginöz Nilay , Kalnis Gregoris , Mateo Mari-Carmen Garcia , Milousi Maria , Mousavi Alireza , Rinčić Iva , Rizzo Agatino , Rodriguez-Roda Ignasi , Rugani Benedetto , Šalaševičienė Alvija , Sari Ramazan , Stanchev Peyo , Topuz Emel , Atanasova Natasa 
Published: March 2020

Abstract
The linear pattern of production-consumption-disposal of cities around the world will continue to increase the emission of pollutants and stocks of waste, as well as to impact on the irreversible deterioration of non-renewable stocks of raw materials. A transition towards a circular pattern proposed by the concept of ‘Circular Cities’ is gaining momentum. As part of this urban transition, the emergent use of Nature-based Solutions (NBS) intends to shift public opinion and utilize technology to mitigate the urban environmental impact. In this paper, an analysis of the current research and practical investments for implementing NBS under the umbrella of Circular Cities is conducted. A combined appraisal of the latest literature and a survey of ongoing and completed National-European research and development projects provides an overview of the current enabling tools, methodologies, and initiatives for public engagement. It also identifies and describes the links between facilitators and barriers with respect to existing policies and regulations, public awareness and engagement, and scientific and technological instruments. The paper concludes introducing the most promising methods, physical and digital technologies that may lead the way to Sustainable Circular Cities. The results of this research provide useful insight for citizens, scientists, practitioners, investors, policy makers, and strategists to channel efforts on switching from a linear to a circular thinking for the future of cities.
Modelling heat recovery potential from household wastewater
Authors: Wärff C. , Arnell M. , Sehlén R. , Jeppsson U. 
Published: March 2020

Abstract
There is a strongly growing interest for wastewater heat recovery (WWHR) in Sweden and elsewhere, but a lack of adequate tools to determine downstream impacts due to the associated temperature drop. The heat recovery potential and associated temperature drop after heat recovery on a building level is modelled for a case study in Linköping, Sweden. The maximum temperature drop reaches 4.2 °C, with an annual recovered heat of 0.65 kWh · person−1 · day−1. Wastewater temperature out from the heat exchanger was 18.0 °C in winter at the lowest. The drinking water source type can be an important factor when considering wastewater heat recovery.
Environmental and cost benefits of co-digesting food waste at wastewater treatment facilities
Authors: Morelli Ben , Cashman Sarah , Ma Xin (Cissy) , Turgeon Jason , Arden Sam , Garland Jay 
Published: March 2020

Abstract
The wastewater industry is undergoing a paradigm shift from focusing solely on treatment to incorporating concepts aimed at mitigating environmental impacts such as energy and nutrient recovery and water reuse. This study uses life cycle assessment and life cycle cost analysis to investigate the effect of expanding anaerobic digestion (AD) capacity and adding combined heat and power on environmental and cost indicators at a mid-sized wastewater treatment facility (WWTF) in Massachusetts, USA. Since 2014, Massachusetts has banned the disposal of organic waste from commercial organizations producing more than one ton of material per week. The WWTF's additional digester capacity allows the co-digestion of municipal solids with a food-based engineered bioslurry due to this ban. Study data were compiled for several AD feedstock quantity and performance scenarios, and compared to a baseline scenario representative of historic plant operations prior to co-digestion. Reductions in environmental impact are demonstrated for six of eight environmental impacts, including global climate change potential and cumulative energy demand. Eutrophication potential increases by 10 percent and 24 percent across assessed scenarios. Water use remains relatively constant across scenarios. Facility energy production increases dramatically with co-digestion, satisfying 100 percent of the WWTF's thermal energy requirement and producing surplus electricity assuming full AD capacity utilization.
Microscopic Image Segmentation to Quantification of Leishmania Infection in Macrophages
Authors: Coelho Guilherme , Galvão Filho Arlindo Rodrigues , Viana-de-Carvalho Rafael , Teodoro-Laureano Gustavo , Almeida-da-Silveira Samyra , Eleutério-da-Silva Clebio , Pereira Rosa Maria Plácido , Soares Anderson da Silva , Soares Telma Woerle de Lima , Gomes-da-Silva Adriano , Napolitano Hamilton Barbosa , Coelho Clarimar José 
Published: March 2020

The determination of infection rate parameter from in vitro macrophages infected by Leishmania amastigotes is fundamental in the study of vaccine candidates and new drugs for the treatment of leishmaniasis. The conventional method that consists in the amastigotes count inside macrophages, normally is done by a trained microscope technician, which is liable to misinterpretation and sampling. The objective of this work is to develop a method for the segmentation of images to enable the automatic calculation of the infection rate by amastigotes. Segmentation is based on mathematical morphology in the context of a computer vision system. The results obtained by computer vision system presents a 95% accuracy in comparison to the conventional method. Therefore, the proposed method can contribute to the speed and accuracy of analysis of infection rate, minimizing errors from the traditional methods, especially in situations where exhaustive repetitions of the procedure are required from the technician.
‘Do not Do’ Recommendations in Hemophilia
Authors: De la Corte-Rodriguez Hortensia , Rodriguez-Merchan E. Carlos , Alvarez-Roman M. Teresa , Martin-Salces Monica , Jimenez-Yuste Victor 
Published: March 2020

Background:
It is important to discard those practices that do not add value. As a result,
several initiatives have emerged. All of them try to improve patient safety and the use of health
resources.

Purpose:
To present a compendium of "do not do recommendations" in the context of hemophilia.

Methods:
A review of the literature and current clinical guidelines has been made, based on the best
evidence available to date.

Results:
The following 13 recommendations stand out: 1) Do not delay the administration of factor
after trauma; 2) do not use fresh frozen plasma or cryoprecipitate; 3) do not use desmopressin in
case of hematuria; 4) do not change the product in the first 50 prophylaxis exposures; 5) do not
interrupt immunotolerance; 6) do not administer aspirin or NSAIDs; 7) do not administer intramuscular
injections; 8) do not do routine radiographs of the joint in case of acute hemarthrosis; 9) Do
not apply closed casts for fractures; 10) do not discourage the performance of physical activities;
11) do not deny surgery to a patient with an inhibitor; 12) do not perform instrumental deliveries in
fetuses with hemophilia; 13) do not use factor IX (FIX) in patients with hemophilia B with inhibitor
and a history of anaphylaxis after administration of FIX.

Conclusions:
The information mentioned previously can be useful in the management of hemophilia,
from different levels of care. As far as we know, this is the first initiative of this type regarding
hemophilia.
Adopting Patient Portals in Hospitals: Qualitative Study
Authors: Hulter Pauline , Pluut Bettine , Leenen-Brinkhuis Christine , de Mul Marleen , Ahaus Kees , Weggelaar-Jansen Anne Marie 
Published: March 2020

BackgroundTheoretical models help to explain or predict the adoption of electronic health (eHealth) technology and illustrate the complexity of the adoption process. These models provide insights into general factors that influence the use of eHealth technology. However, they do not give hospitals much actionable knowledge on how to facilitate the adoption process.ObjectiveOur study aims to provide insights into patient portal adoption processes among patients and hospital staff, including health care professionals (HCPs), managers, and administrative clerks. Studying the experiences and views of stakeholders answers the following question: How can hospitals encourage patients and HCPs to adopt a patient portal?MethodsWe conducted 22 semistructured individual and group interviews (n=69) in 12 hospitals and four focus groups with members of national and seminational organizations and patient portal suppliers (n=53).ResultsThe effort hospitals put into adopting patient portals can be split into three themes. First, inform patients and HCPs about the portal. This communication strategy has four objectives: users should (1) know about the portal, (2) know how the portal works, (3) know that action on the portal is required, and (4) know where to find help with the portal. Second, embed the patient portal in the daily routine of HCPs and management. This involves three forms of support: (1) hospital policy, (2) management by monitoring the numbers, and (3) a structured implementation strategy that includes all staff of one department. Third, try to adjust the portal to meet patients’ needs to optimize user-friendliness in two ways: (1) use patients’ feedback and (2) focus on optimizing for patients with special needs (eg, low literacy and low digital skills).ConclusionsAsking stakeholders what they have learned from their efforts to stimulate patient portal use in hospitals elicited rich insights into the adoption process. These insights are missing in the theoretical models. Therefore, our findings help to translate the relatively abstract factors one finds in theoretical models to the everyday pragmatics of eHealth projects in hospitals.
Intracardiac echocardiography use and outcomes after catheter ablation of ventricular tachycardia
Authors: Field Michael E , Goldstein Laura , Yu Lee Stephanie Hsiao , Kalsekar Iftekhar , Coplan Paul , Wong Charlene , Khanna Rahul , Gold Michael R , Reynolds Matthew R , Winterfield Jeffrey R 
Published: March 2020

Aim:
To compare outcomes among patients with implantable cardioverter defibrillator/cardiac resynchronization therapy-defibrillator undergoing outpatient ventricular tachycardia (VT) catheter ablation using intracardiac echocardiography (ICE) versus no ICE.
Patients & methods:
Patients were classified into ICE (n = 1143)/non-ICE (n = 1677) groups based on ICE procedure codes. Patients in each group were propensity matched on study covariates. Survival analyses were used to assess outcomes. To examine residual confounding, falsification outcomes were evaluated.
Results:
ICE patients had a 24% lower risk of all-cause readmissions, 24% lower risk of cardiovascular-related and 20% lower risk of VT-related readmissions compared with non-ICE patients. Falsification analyses for ICE use association were nonsignificant.
Conclusion:
Patients with implantable cardioverter defibrillator/cardiac resynchronization therapy-defibrillator undergoing VT ablation with ICE use had significantly lower likelihood of VT-related readmission.
Measuring of Amplitudes, Frequencies and Phases of Simple Periodic Components of the Complex Signal at Spectral Analysis by Fast Fourier Transform
Authors: Lеn’kоv S. V. 
Published: March 2020

Предложен способ оценки амплитуд, частот и фаз конечного числа простых периодических составляющих сложного сигнала по дискретному спектру сложного сигнала, полученному быстрым преобразованием Фурье. В предложенных алгоритмах используются априорные данные (объем реализации и шаг дискретизации) и измеренные или вычисленные данные (действительные и мнимые части отсчетов спектра, лежащих около наибольших максимумов модуля спектра).Проведено моделирование работы предложенного алгоритма. Моделировался суммарный сигнал, состоящий из семи синусоид с единичными амплитудами, разными частотами и фазами. Шум канала моделировался добавлением нормально распределенной случайной величины к точному отсчету суммарного сигнала, а помеха 50 Гц – добавлением реализации синусоиды со случайной амплитудой и фазой. Определение параметров слагаемых синусоид осуществлялось двумя итерационными способами. При первом способе суммарный спектр сигнала рассматривался как сумма спектров семи независимых сигналов; при втором способе – как сумма спектров независимых пар сигналов. Погрешности определения фаз не превосходили 3 %, а погрешности измерения амплитуд и частот – 1 %.Проведенное исследование может служить теоретическим обоснованием алгоритма измерения амплитуд, частот и фаз конечного числа простых периодических составляющих сложного сигнала с помощью быстрого преобразования Фурье при отсутствии априорных сведений о параметрах сигнала с использованием только действительных и мнимых составляющих дискретного спектра сигнала.
Pressurized Perfusion System for Obtaining Completely Acellular Pulmonary Valve Scaffolds for Tissue Engineering
Authors: Ionela Movileanu , Klara Brinzaniuc , Marius Harpa , Dan Nistor , Ovidiu Cotoi , Preda Terezia , Al Hussein Hussam , Oana Moldovan , Adrian Man , Lucian Harceaga , Leslie Sierad , Dan Simionescu 
Published: March 2020

Abstract
Introduction. Xenogeneic tissues decellularization represents the obtaining process of extracellular matrix derived scaffolds. Most antigens being cell based, non-immunogenicity is obtained by cells removal. Scaffolds are temporary structures with biologic and mechanical role. Scaffolds, stem cells and bioreactors represent premise of regenerative medicine, aiming towards the ideal valvular substitute. In previous studies, we decellularized pulmonary valves root by immersion histology revealing cellular residue, requiring a more efficient approach. We hypothesized that immersion is insufficient and thus a pressure gradient was added.
Material and Method. This is part of a grant approved by the UMFTS. Eleven porcine pulmonary valves were included in the study: n=6 underwent immersion decellularization and n=5 were cyclically perfused with a 20-25mmHg pressure gradient during a 10-day protocol. The acellular valves obtained underwent a quality control using DAPI (4′,6-diamidino-2-phenylindol) nuclear staining, histological Haematoxylin-Eosin, DNA extraction and quantification, harvested from different structural levels: arterial wall, sinus, cusp.
Results. Histological assessments highlighted integrity of extracellular matrix in both groups and overall cells absence at the different levels of valvular structures analyzed. Immersion decellularized valves exhibited DAPI positive structures identified as potential residual nucleic material. Comparatively, the perfusion decellularized valves, lacked in those structures, result confirmed by DNA extraction and quantitation procedure.
Conclusions. Perfusion decellularization represents a feasible approach to obtain acellular cardiac valvular scaffolds derived from the extracellular matrix, being superior to immersion decellularization method. Their nonimmunogenic potential is underlined by total absence of nuclei. The process is fast, allowing production of an abundant number of valvular biomaterials in a short time.
Corelattions Between CD31, CD68, MMP-2 and MMP-9 Expression in Allograft Cardiac Rejection – Immunohistochemical Study
Authors: Bogdan Grecu Vasile , Pavel Onofrei , Cristina Dimitriu Daniela , Doinita Temelie Olinici , Laura Stoica , Emanuela Botez Ana , Laurentiu Indrei Lucian , Alexandra Popa Alina , Carmen Solcan , Ileana Sin Anca , Carmen Cotrutz Elena 
Published: March 2020

Abstract
Introduction. The cardiac allograft rejections from the post-transplant period are attributable to the acute cellular rejection monitored by multiple endomyocardial biopsies. Compared to this, humoral rejection remains a matter of debate, with multiple therapeutic strategies, poor prognosis, and persisting uncertainty about diagnostic criteria. Acute allograft rejection is associated with significant modifications of the extracellular matrix compartment mainly regulated by matrix metalloproteinases (MMPs). In this context, the aim of this study was to evaluate the expression of MMP-2 and -9 and CD31, CD68 (endothelial and histiocytic markers) and the correlations between them using immunohistochemistry, in patients with cardiac allografts.
Materials and methods. Tissue fragments were obtained by endomyocardial biopsy from 5 patients with allograft heart transplant, 2 in the medium post-transplant phase and 2 in late phase. After identifying and characterizing the morphological context the probes were processed by standard immunohistochemical technique using anti-MMP-2 and anti-MMP-9 antibodies (Santa Cruz Biotechnology, Inc.) and anti-CD31, anti-CD68 antibodies (Sigma). The samples were examined using the Olympus BX40 microscope with an Olympus E330 camera attached.
Results and discussions. Sample examination revealed in all 4 cases the lack of IR (-) for CD31 and weak IR (+) for CD68 compared to MMPs, where we found moderate IR (++) for MMP-9 and weak IR (+) for MMP-2. These aspects complets the histological lesional aspects of these cases, indicating the lack of acute rejection. In conclusion, CD31 and CD68 IR correlated with MMPs IR (especially MMP-9) appear to represent predictive markers for cardiac allograft rejection and require further studies.
Exteriorized Giant Zenker’s Diverticulum: Case Report
Authors: Antoaneta Oancea Alina Lavinia , Bogdan Popescu , Gabriela Androne Roxana , Gabriel Berteșteanu Serban Victor 
Published: March 2020

Abstract
Zenker’s diverticulum (ZD) also known as cricopharyngeal (CP), pharyngoesophageal or hypopharyngeal diverticulum is an outpouching of mucosal and submucosal layers originated from the pharyngoesophageal junction. Radiological evaluation of deglutition, modified barium swallow radiography may reveal the retentive character of the diverticular sac and confirm the diagnosis. Many different types of surgical approaches have been developed over the decades with modifications focusing on the need to reduce intra-operative or post-operative complications and overall morbidity. The authors present the case of a 76-years-old woman with spontaneous apparition of an exteriorised tumor in the oral cavity after an excessive cough effort. Surgical treatment is elective, preventing the occurence of complications that may endanger the patients life and improve the quality of life. Surgical therapy was open neck resection of the Zenker’s diverticulum with esophageal myotomy and pharynx reconstruction.
Limitations of the CAD-CAM System in the Process of Weaving
Authors: Kovačević Stana , Brnada Snježana , Šabarić Irena , Karin Franka 
Published: March 2020

Abstract
The weaving process is constantly evolving in terms of productivity, quality, and possibilities of fabrication of different fabric structures and shapes. This article covers some issues that have still not been resolved and represents distracting factors in the woven fabrics production. In the development of woven fabric using the CAD technology, it is inevitably a deviation of the virtual image on the computer screen from the woven sample. According to comprehensive industry analyses, the findings of many authors who contributed to the resolution of these problems can be concluded that these problems are still present in the development and production of striped, checkered, and jacquard woven fabrics. In this article, jacquard, multicolor woven fabrics were investigated, with deviations in pattern sizes and shades of color in warp and weft systems compared to virtual simulation on the computer, as well as the tendency of the weft distortion arising from the weaving process leading to the pattern deformation.
Awareness Logic: an Epistemological Defence Correlations between Awareness Logic and Epistemology
Authors: Fernández-Fernández Claudia 
Published: March 2020

Abstractwith this paper, we intend to clarify some of the central notions that are commonly used in contemporary developments of Epistemic Logic, which lack a proper theoretical foundation. We want to follow the steps of some prominent epistemologists and epistemic logicians, who advocate for a correlation between their respective fields of study. We will proceed with a first small step that will consist in adapting one contemporary version of Epistemic Internalism to the framework of Awareness Logic, such that the key concepts in this logic can be sustained by an epistemological view, which, in turn, can work as a theoretical foundation for Awareness Logic.