bluuebunny/crossref_metadata_2025_split huggingface dataset:
Branch-type intraductal papillary neoplasm of the bile duct treated with laparoscopic anatomical resection: a case report
Authors: Matono Rumi , Ninomiya Mizuki , Morita Kazutoyo , Tomino Takahiro , Oshiro Yumi , Yokota Tomoyuki , Nishizaki Takashi 
Published: May 2020

Abstract
Background
Intraductal papillary neoplasm of the bile duct (IPNB) is characterized by an intraluminal, growing papillary tumor covered by neoplastic biliary epithelial cells with a fine fibrovascular core. IPNB was introduced as a precancerous and early neoplastic lesion in the 2010 World Health Organization classification of tumors of the digestive system. IPNB eventually invades the bile duct wall and progresses to invasive cholangiocarcinoma. IPNB resembles intraductal papillary mucinous neoplasm of the pancreas (IPMN), particularly the main pancreatic duct type.
IPNB cases, possibly corresponding to branch-type IPMN, have been recently reported, and these cases involved the peribiliary glands significantly and showed gross cystic dilatation. Small branch-type intrahepatic IPNB often mimics simple liver cysts, making the diagnosis of IPNB difficult. Some literature recommended surgical resection for treatment. Laparoscopic resection is a good treatment option for small tumor. We herein present the case of branch-type IPNB that was treated with laparoscopic anatomical liver resection 5 years after being detected.

Case presentation
A 64-year-old woman was undergoing follow-up for primary aldosteronism. In 2012, follow-up computed tomography (CT) incidentally revealed a 7-mm cystic lesion in segment 8 of the liver. From 2012 to 2017, the cystic lesion kept increasing in size, reaching 17 mm. In 2017, CT also revealed a 13-mm mural nodule in the cyst wall. Therefore, the patient was referred to our department for possible malignancy.
We suspected a branch-type IPNB; however, the mass was small and diagnosis could not be made without performing biopsy. Accordingly, surgical resection was performed for diagnosis and treatment. Because branch-type IPNB might show horizontal spread through the intrahepatic bile duct, we believed that anatomical resection of the liver was appropriate considering the malignant potential of the lesion. Therefore, laparoscopic anatomical resection of segment 8 of the liver was performed. The resected tumor measured 17 mm and was histologically diagnosed as a high-grade IPNB.

Conclusion
Branch-type IPNBs are rare but can potentially lead to malignant tumors. Surgical resection is the treatment of choice, with laparoscopic anatomical resection being a good treatment option for this small tumor.
The TDR MOOC training in implementation research: evaluation of feasibility and lessons learned in Rwanda
Authors: Hooley Cole , Baumann Ana A. , Mutabazi Vincent , Brown Angela , Reeds Dominic , Cade W. Todd , Fuentes Lisa de las , Proctor Enola K. , Karengera Stephen , Schecthman Kenneth , Goss Charles , Launois Pascal , Davila-Roman Victor G. , Mutimura Eugene 
Published: May 2020

Abstract
Background
Hypertension (HTN) affects nearly 1 billion people globally and is a major cause of morbidity and mortality. In low- and middle-income countries (LMICs), HTN represents an unmet health care gap that can be addressed by strengthening national health care systems. The National Heart, Lung, and Blood Institute recently funded the T4 Translation Research Capacity Building Initiative in Low Income Countries (TREIN) program to build capacity in dissemination and implementation (D&I) research in HTN in LMICs. The Special Programme for Research and Training in Tropical Diseases (TDR) at the World Health Organization (WHO) recently developed a massive open online course (MOOC) to train in D&I. Herein, we report on the use of the TDR WHO MOOC in D&I for the TREIN program in Rwanda, assessing feasibility of the MOOC and D&I competencies after MOOC training.

Methods
Participants in one-group MOOC training completed pre- and post-training questionnaires to assess dissemination and implementation (D&I) competency outcomes and feasibility. D&I competencies were measured by use of a scale developed for a US-based training program, with the change in competency scores assessed by paired t test. Feasibility was measured by completion of homework and final project assignment and analyzed using descriptive statistics.

Results
Of the 92 trainees enrolled, 35 (38%) completed all MOOC components. D&I competency scores showed strong evidence of improvements from pre- to post-test. The full-scale average score improved by an average of 1.09 points, representing an effect size of 1.25 (CI 0.48-2.00); all four subscales also showed strong evidence of improvements. Trainees reported challenges to MOOC course completion that included technological issues (i.e., limited internet access) and competing demands (i.e., work, family).

Conclusions
In the context of LMIC training, the MOOC course was feasible and course completion showed improvement in D&I competency scores. While the program was designed with a focus on training for tropical diseases, there is potential for scalability to a wider audience of health care researchers, workers, administrators, and policymakers in LMIC interested in D&I research in non-communicable diseases.
Classes of tree-based networks
Authors: Fischer Mareike , Galla Michelle , Herbst Lina , Long Yangjing , Wicke Kristina 
Published: May 2020

AbstractRecently, so-called tree-based phylogenetic networks have attracted considerable attention. These networks can be constructed from a phylogenetic tree, called the base tree, by adding additional edges. The primary aim of this study is to provide sufficient criteria for tree-basedness by reducing phylogenetic networks to related graph structures. Even though it is generally known that determining whether a network is tree-based is an NP-complete problem, one of these criteria, namely edge-basedness, can be verified in linear time. Surprisingly, the class of edge-based networks is closely related to a well-known family of graphs, namely, the class of generalized series-parallel graphs, and we explore this relationship in full detail. Additionally, we introduce further classes of tree-based networks and analyze their relationships.
Multi-vortex laser enabling spatial and temporal encoding
Authors: Qiao Zhen , Wan Zhenyu , Xie Guoqiang , Wang Jian , Qian Liejia , Fan Dianyuan 
Published: May 2020

AbstractOptical vortex is a promising candidate for capacity scaling in next-generation optical communications. The generation of multi-vortex beams is of great importance for vortex-based optical communications. Traditional approaches for generating multi-vortex beams are passive, unscalable and cumbersome. Here, we propose and demonstrate a multi-vortex laser, an active approach for creating multi-vortex beams directly at the source. By printing a specially-designed concentric-rings pattern on the cavity mirror, multi-vortex beams are generated directly from the laser. Spatially, the generated multi-vortex beams are decomposable and coaxial. Temporally, the multi-vortex beams can be simultaneously self-mode-locked, and each vortex component carries pulses with GHz-level repetition rate. Utilizing these distinct spatial-temporal characteristics, we demonstrate that the multi-vortex laser can be spatially and temporally encoded for data transmission, showing the potential of the developed multi-vortex laser in optical communications. The demonstrations may open up new perspectives for diverse applications enabled by the multi-vortex laser.
Multicenter Validation Study to Implement Plasma Epidermal Growth Factor Receptor T790M Testing in Clinical Laboratories
Authors: Leighl Natasha B. , Kamel-Reid Suzanne , Cheema Parneet K. , Laskin Janessa , Karsan Aly , Zhang Tong , Stockley Tracy , Barnes Tristan A. , Tudor Roxana A. , Liu Geoffrey , Owen Scott , Rothenstein Jeffrey , Burkes Ronald L. , Iqbal Mussawar , Spatz Alan , van Kempen Léon C. , Izevbaye Iyare , Laurence David , Le Lisa W. , Tsao Ming-Sound 
Published: May 2020

PURPOSE Plasma detection of EGFR T790M mutations is an emerging alternative to tumor rebiopsy in acquired epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor resistance. Validation of analytical sensitivity and clinical utility is required before routine diagnostic use in clinical laboratories. PATIENTS AND METHODS Sixty-three patients with advanced EGFR-mutant lung cancer at 7 Canadian centers, who were being screened for the ASTRIS trial (ClinicalTrials.gov identifier: NCT02474355 ), participated in this companion study. Plasma T790M mutation was detected using droplet digital polymerase chain reaction, Cobas (Roche Diagnostics, Indianapolis, IN), or next-generation sequencing in 4 laboratories. T790M concordance was assessed between plasma and tumor samples. RESULTS Assessment of T790M in tumor biopsy tissue was successful in 81% of patients; 49% had confirmed T790M results (tumor or plasma) for ASTRIS. Plasma testing in this companion study yielded T790M results in 97% of patients; 62% had T790M-positive results, 36% had negative results, and 2% had indeterminate results. Of 38 patients with negative or indeterminate biopsy results, 55% had positive plasma T790M results, increasing the proportion with T790M-positive results to 73%. Sensitivity of plasma T790M testing was 75%. Overall concordance between tissue and plasma was 64%, and concordance among laboratories was 90.3%. Response to osimertinib and duration of therapy were similar irrespective of testing method (overall response rate, 62.5% for tissue, 66.7% for plasma, and 70.6% for both). CONCLUSION This multicenter validation study demonstrates that plasma EGFR T790M testing can identify significantly more patients than biopsy alone who may benefit from targeted therapy.
LncRNA NEAT1 mediates sepsis progression by regulating Irak2 via sponging miR-370-3p
Authors: Xiao Ting , Sun Chuihua , Xiao Ying , Li Yunbao 
Published: May 2020

Background: Sepsis is a life-threatening condition and often associated with multiple organ failure. Nuclear-enriched abundant transcript 1 (NEAT1), a member of long non-coding RNAs (lncRNAs), was reported to be involved in the regulation of sepsis progression. However, its precise regulatory mechanism needs to be further explored.
Methods: CCK-8 assay was utilized to check cell viability. The qRT-PCR was employed to detect the expression levels of NEAT1, miR-370-3p and iIrak2. Flow cytometry assay and ELISA were used to check cell apoptosis and the concentrations of inflammatory cytokines, respectively. The starBase was used to predict binding sites between miR-370-3p and NEAT1 or Irak2 and the dual-luciferase reporter assay was performed to verify the interaction. The protein level of Irak2 in samples was measured by western blot.
Results: The high concentration of lipopolysaccharide (LPS) led to the high death ratio of RAW 264.7 and HL-1 cells. Besides, NEAT1 and Irak2 were upregulated in sepsis tissues and LPS-induced RAW 264.7 and HL-1 cells, opposite to the expression of miR-370-3p. In addition, knockdown of NEAT1 promoted viability, suppressed apoptosis and reduced the expression of inflammatory cytokines in LPS-induced RAW 264.7 and HL-1 cells. Moreover, we found that miR-370-3p interacted with NEAT1 and targeted the 3'UTR of Irak2. Further research indicated that downregulation of miR-370-3p or upregulation of IraK2 rescued NEAT1 silencing-mediated inhibitory effect on sepsis progression.
Conclusion: Knockdown of NEAT1 hampered sepsis progression by downregulating Irak2 via interacting with miR-370-3p in LPS-induced RAW 264.7 and HL-1 cells.
Exercise Patterns and Perceptions among South Asian Adults in the United States: The SHAPE Study
Authors: Frediani Jennifer K. , Shaikh Nida I. , Weber Mary Beth 
Published: May 2020

ABSTRACT
Our objective was to determine biological differences and perceptions about exercise among an immigrant South Asian population living in the southern United States. This is a descriptive study of exercise patterns and perceptions using baseline data from a diabetes intervention study with immigrant South Asian adults now living in the United States. The sample included middle-aged, predominantly male, well-educated, immigrant South Asians. Participants were recruited through advertisements in local South Asian magazines, information sent through community organization listservs, and in-person outreach at health fairs and screening, diabetes information events, and South Asian stores. Participants reported to the Georgia Clinical and Translational Science Alliance General Clinical Research Center at Emory University Hospital and completed a baseline visit for the South Asian Health and Prevention Education pilot study. The mean ± SD age of this cohort was 44.6 ± 10.6 yr and 35% female. Of the 52 people included in this analysis, 81% did not exercise at least 150 min·wk−1 to meet the U.S. Physical Activity Guidelines. Of those that did meet the Physical Activity Guidelines, 90% reported walking as their primary form of exercise. Overall, 65% reported preferring walking to other modes of exercise. There were no differences between high exercisers and low exercisers when asked about the benefits or barriers of exercise. South Asians living in the southern United States do not meet the U.S. Physical Activity Guidelines. The preferred mode of exercise is walking close to home. Although barriers to exercise are similar to those of other races in the United States, preferred mode of exercise and preferences of women should be considered when implementing physical activity interventions.
METHODOLOGICAL BASIS FOR ASSESSING THE READINESS OF THE UNIVERSITY TO INTRODUCE DIGITAL TECHNOLOGIES
Authors: Mitrofanova Elena , Mitrofanova Aleksandra 
Published: May 2020

The effectiveness of professional education substantially depends on the wide use of digital technologies and products in the educational process. However, the effectiveness of the implementation of these technologies largely depends, on the one hand, on the readiness of the digital educational environment, and on the other hand, on the level of digital literacy and the competence of the teachers. So, it is necessary to develop a methodology for assessing the level of preparation of the university for digitalization, the purpose of which is to provide a unified approach to the assessment of the educational information environment and the factors providing it in the educational process, as well as to remove obstacles to the effective implementation of educational programmes and services using digital technologies and products. The analysis of the existing methods has shown that they assess the level of the digital development of various sectors of the economy and society in general, but do not affect the educational system or evaluate the digitalization of the educational process only from the technical point of view.
Taking into account all the above-mentioned circumstances, the authors propose to evaluate the readiness of universities for digitalization of the educational process on the basis of the analysis of the factors directly affecting the digitalization of the educational process, such as: digital transformation of the educational environment of the university and the level of preparation of the teachers for the work in the digital environment.
Advertising Spending and Media Bias: Evidence from News Coverage of Car Safety Recalls
Authors: Beattie Graham , Durante Ruben , Knight Brian , Sen Ananya 
Published: May 2020

Do mass media bias content in favor of advertisers? If so, what market conditions limit or exacerbate this bias? We examine the relationship between advertising by auto manufacturers in U.S. newspapers and news coverage of car safety recalls between 2000 and 2014. This context allows us to separate the influence of advertisers, who prefer less coverage, from that of readers, who prefer more information about the safety risks associated with the recalls. Consistent with theoretical predictions, we find that newspapers provide less coverage of recalls issued by manufacturers that advertised more regularly on their pages over the previous two years. The effect is especially pronounced for more severe recalls, which are more likely to hurt manufacturers’ reputations. Competition for readers from other newspapers mitigates proadvertiser bias, and competition for advertising by online platforms exacerbates it. We also present suggestive evidence that less news coverage of recalls is associated with more fatal car accidents. This paper was accepted by Joshua Gans, business strategy.
O SENTIDO DE PARTICIPAÇÃO NAS ESCOLAS PÚBLICAS ESTADUAIS DO MUNICÍPIO DE ASSU/RN: POSSIBILIDADE DE CONSTRUÇÃO DEMOCRÁTICA
Authors: Fonseca Maria da Conceição , Medeiros Arilene Maria Soares de 
Published: May 2020

Este trabalho compreende parte de uma pesquisa de dissertação e objetiva analisar o sentido atribuído pelos gestores escolares quanto à participação dos sujeitos nas escolas públicas estaduais do município de Assú/RN. O problema deriva da seguinte questão: Qual o sentido de participação para os gestores escolares em tempos de gerencialismo? A abordagem da investigação é qualitativa, tendo como procedimento de construção de dados a pesquisa bibliográfica e o diário de pesquisa (BARBOSA, 2010). Como fundamentação teórica, amparamo-nos em Arendt (2011), Lima (2007), Frateschi (2007) e Barbosa (2010), dentre outros autores. A participação evita a tomada de decisões unilaterais e constitui exercício de liberdade política e desenvolvimento de uma cultura democrática. Palavras-chave: Participação. Espaço escolar. Gestão Democrática. Gerencialismo.
Post-war fashion tips in the popular fashion press in Poland: A source of psychological support in the 'struggle for femininity'
Authors: Idem Magdalena 
Published: May 2020

Abstract
Social conditions in Poland were harsh at the conclusion of World War II. Surprisingly, interest in fashion revived quickly after the war, giving rise in 1945 to a hugely popular fashion press, avidly read by Polish women. The independent magazine Fashion and Practical Life (Moda i Życie Praktyczne), launched in December 1945, was the first of its kind in Poland after the war, and quickly gained a large readership of urban and rural women (and significant numbers of men). It centred on fashion tips  from practical advice on how to remodel existing material into new clothing to more aspirational ideas, crossing over from the necessities of dress or clothing into the more imaginary realm of 'fashion'.
Unlike readers of the fashion press before the war, the readership of this magazine was not leisured or highly literate, but largely 'ordinary' women trying to deal with the realities of their circumstances and to find relief from them. Letters from readers were the centre of the magazine in its early years. They shared their experiences and solutions. This article explores the phenomenon of a genre of publishing for women in Poland through analysis of Fashion and Practical Life from its inception into the early 1950s. It examines the contexts in which it operated and its role in the representation and self-identity of Polish women within this time of transition. The article identifies two key typologies for fashion tips: 'poor fashion' (how to make available materials into liveable garments) and 'imaginary fashion' (the aspirations that Polish women had but could not attain at that time). It also shows that apparently emancipatory trends for women were short-lived. By the early 1950s the narrative of the fashion press reinscribed Polish women back in the home, as housewives.
Gene selection in Cox regression model based on a new adaptive penalized method
Authors: Isam Alskal Oday , Yahya Algamal Zakariya 
Published: May 2020

The common issues of high dimensional gene expression data for survival analysis are that many of genes may not be relevant to their diseases. Gene selection has been proved to be an effective way to improve the result of many methods. The Cox proportional hazards regression model is the most popular model in regression analysis for censored survival data. In this paper, an adaptive penalized Cox proportional hazards regression model is proposed, with the aim of identification relevant genes and provides high classification accuracy, by combining the Cox proportional hazards regression model with the weighted least absolute shrinkage and selection operator (LASSO) method. Experimental results show that the proposed method significantly outperforms two competitor methods in terms of the area under the curve and the number of the selected genes.Â Â
HUBUNGAN PENGETAHUAN, SIKAP, DAN MOTIVASI DENGAN KEPATUHAN KONSUMSI TABLET BESI FOLAT PADA IBU HAMIL
Authors: Budiarni Widya , Subagio Hertanto Wahyu 
Published: May 2020

Background: The benefit of giving free iron folic tablets to prevent iron deficiency anemia in pregnancy is often inhibited by the compliance of iron folic tablets consumption in pregnant women. Compliance is a behavior that can be influenced by many factors, such as knowledge, attitude and motivation. The purpose of this study is to determine association between knowledge, attitude, and motivation with compliance of iron folic tablets consumption in pregnant women. Methods: This is a cross sectional study, with 56 pregnant women as sample which are selected by consecutive sampling in Halmahera health center, Semarang. Data of compliancy on iron folic tablets consumption was measured by tablet calculation. Data of knowledge, attitude and motivation are taken from interviews using questionnaire. Bivariate analysis performed by Rank Spearman test. Results: This study showed 41,1% of subjects complied iron folic tablet consumption. The average compliance of iron folic tablet consumption in 10 days is 62.86%. Majority of pregnant women have a good knowledge (50%), good attitude (51.8%) and good motivation (57.1%). This study showed association between knowledge (r = 0.370, p = 0.005), attitude (r = 0.343, p = 0.010), and motivation (r = 0.616, p = 0.000) with compliance of iron folic tablets consumption. Conclusion: Motivation is the most dominant factor. The higher the motivation given the more compliance the pregnant women of taking iron folic tablets consumption.
PENGARUH PEMBERIAN JUS LIDAH BUAYA TERHADAP KADAR GLUKOSA DARAH PUASA PADA WANITA PREDIABETES
Authors: Pertiwi Putri Sukma , Rahayuningsih Hesti Murwani 
Published: May 2020

Background: Prediabetes is a condition which pioneers of DM. Diet management is the effective method to decrease fasting blood glucose (FBG) level. One of plant that correlates decreasing FBG level is Aloe vera. The purpose of the study was to prove the effects of Aloe vera on FBG level in prediabetes women. Method: This study was quasi experiment with pre test-post test design. The subjects were people in Tlogosari Kulon Semarang who taken by consecutive sampling. Total subjects were 26 people which was divided in 2 groups. The treatment group was given juice Aloe vera 150 gram per day during 14 days and control group was not given juice Aloe vera. FBG level was measured before and after intervention using spectrofotometri method. During intervention, both of group recorded food intake using food record and food recall. Data was analyzed by Independent sample t-test, Mann Whitney test, and Wilcoxon test. Result : The decreasing of FBG level in treatment group was 20.38±14.7 (18.92%) mg/dl and control group was 0.38±11.12 mg /dl. Statistic analysis showed that there was significant difference at decreasing of FBG level in treatment group and control group. Conclusion : There was significant decreasing FBG level 20.38 mg/dl after given juice Aloe vera 150 gram per day during 14 days.