bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statistic estimation of cell compressibility based on acoustophoretic separation data
Authors: Garofalo Fabio , Lenshof Andreas , Urbansky Anke , Olm Franziska , Bonestroo Alexander C. , Ekblad Lars , Scheding Stefan , Laurell Thomas 
Published: August 2020

AbstractWe present a new experimental method that measures the compressibility of phenotype-specific cell populations. This is done by performing statistical analysis of the cell counts from the outlets of an acoustophoresis chip as a function of the increasing actuator voltage (i.e. acoustic energy density) during acoustophoretic separation. The theoretical separation performance curve, henceforth, Side-Stream Recovery ($$\mathrm {SSR}$$
SSR
), vs the piezo-actuator voltage (V) is derived by moment analysis of a one-dimensional model of acoustophoresis separation, accounting for distributions of the cell or microparticle properties and the system parameters (hydrodynamics, radiation force, drag enhancement, and acoustic streaming). The acoustophoretic device is calibrated with polymer microbeads of known properties by fitting the experimental $$\mathrm {SSR}$$
SSR
with the theoretical $$\mathrm {SSR}$$
SSR
, in which the acoustic energy density is considered proportional to the squared voltage, i.e. $$E_\mathrm {ac}^{}=\alpha \,V^2_{}$$

E

ac

=
α

V

2

. The fitting parameter $$\alpha$$
α
for the calibration procedure is the device effectivity, reflecting the efficiency in performing acoustophoretic microparticle displacement. Once calibrated, the compressibility of unknown cells is estimated by fitting experimental $$\mathrm {SSR}$$
SSR
cell data points with the theoretical $$\mathrm {SSR}$$
SSR
curve. In this procedure, the microparticle compressibility is the fitting parameter. The method is applied to estimate the compressibility of a variety of cell populations showing its utility in terms of rapid analysis and need for minute sample amounts.
Surgical outcomes in patients with optic disc pit maculopathy: does peeling the ILM lead to better outcomes?
Authors: Wagner Helena , Pielen Amelie , Agostini Hansjürgen , Böhringer Daniel , Lagrèze Wolf Alexander , Biermann Julia 
Published: August 2020

Abstract
Purpose
Optic disc pits (ODPs) are rare congenital anomalies. Several patients develop optic disc pit maculopathy (ODP-M): visual impairment caused by intra- and/or subretinal fluid. Treatment mode remains controversial. This study was designed to investigate the effectiveness of pars plana vitrectomy (PPV) and gas tamponade with or without internal limiting membrane (ILM)-peeling in improving visual acuity and reducing subretinal fluid in ODP-M patients.

Methods
We retrospectively reviewed the charts of 16 patients who underwent surgery for ODP-M from 2002–2015. Six patients underwent PPV with gas tamponade (group 1); ten patients additionally received ILM-peeling (group 2). Pre- and postoperative visual acuity and central retinal thickness (CRT) were compared between groups, as well as retinal morphology and the number of secondary vitrectomies and complications.

Results
Median visual acuity improved by 2 ETDRS lines in both groups (p = 0.713, Mann–Whitney U test). Median CRT decreased by 426.5 µm and 460 µm (p = 0.931). One patient in group 1 underwent repeat vitrectomy for persistent retinoschisis. Three patients in group 2 required repeat vitrectomy: two to treat a macular hole, one for peripheral retinal holes with retinal detachment.

Conclusion
In our cohort, PPV with gas tamponade proved to be an effective first-line treatment for ODP-M. Additional ILM-peeling did not give a significant benefit in this study.
Comparison of the therapeutic effect of Meibomian Thermal Pulsation LipiFlow® on obstructive and hyposecretory meibomian gland dysfunction patients
Authors: Li Bowen , Fu Hongxue , Liu Tingting , Xu Mei 
Published: August 2020

Abstract
Purpose
To explore the effect of Meibomian Thermal Pulsation LipiFlow® on obstructive and hyposecretory meibomian gland dysfunction.

Methods
Twenty-five subjects diagnosed with obstructive meibomian gland dysfunction (OMGD) and another 25 hyposecretory meibomian gland dysfunction (HMGD) patients were collected receiving the unilateral treatment with LipiFlow®. We evaluated the parameters variables including Standard Patient Evaluation of Eye Dryness (SPEED), Ocular Surface Disease Index (OSDI), Schirmer I test (SIT), noninvasive keratographic breakup time (NIKBUT), tear meniscus height (TMH), and lipid layer thickness (LLT), partial blink rate (PBR), meibomian gland loss, meibomian gland morphology with LipiView®. Meibomian gland expressibility and secretion quality were evaluated for OMGD subjects. All the results were recorded pre-therapy and 4 weeks, 8 weeks, 12 weeks post-therapy.

Results
SPEED, OSDI, and PB decreased, meanwhile, NIKBUT, TMH, SIT, and LLT increased compared with baseline in both groups after treatment (P < 0.001), whereas the magnitude of the improvement in the OMGD group was greater than that in the HMGD group (P < 0.001). There was no significant posttreatment structural meibomian gland change in both groups. The meibomian gland expressibility and secretion quality score increased after treatment in the OMGD group (P < 0.001).

Conclusions
The Meibomian Thermal Pulsation LipiFlow® is effective for both obstructive and hyposecretory meibomian gland dysfunction and the therapeutic effect on obstructive meibomian gland dysfunction is greater than that on hyposecretory meibomian gland dysfunction.
Stable and Metastable Phases for the Curie–Weiss–Potts Model in Vector-Valued Fields via Singularity Theory
Authors: Külske Christof , Meißner Daniel 
Published: August 2020

AbstractWe study the metastable minima of the Curie–Weiss Potts model with three states, as a function of the inverse temperature, and for arbitrary vector-valued external fields. Extending the classic work of Ellis and Wang (Stoch Process Appl 35(1):59–79, 1990) and Wang (Stoch Process Appl 50(2):245–252, 1994) we use singularity theory to provide the global structure of metastable (or local) minima. In particular, we show that the free energy has up to four local minimizers (some of which may at the same time be global) and describe the bifurcation geometry of their transitions under variation of the parameters.
Technology transfer in the construction industry
Authors: Uusitalo Petri , Lavikka Rita 
Published: August 2020

AbstractThe demand for affordable, high-quality homes and premises has increased as society has evolved. Construction companies have shown that an industrialised housebuilding (IHB) platform strategy is an effective way of meeting exacting customer requirements. We decided to apply a managerial perspective and consider the IHB platform as a technological solution when investigating technology transfer (TT) in a construction context. Drawing on a meta-analysis of the literature and a qualitative case study at an IHB company, this work examines how two construction companies participate in TT. The results show that the IHB platform strategy can help a company overcome uncertainties associated with the TT process. Furthermore, the platform strategy supports the transferability of IHB to different markets, which, in turn, provides unique opportunities for companies from other contexts to enter the construction market. Our findings also revealed that CEOs from three construction companies were not only interested in TT due to potential profit improvements, but also considered how the process could benefit their employees and the community. This may be a result that is specific to Nordic culture or insight into a unique characteristic of the broad construction industry. This study contributes knowledge to the scarce research field of TT in a construction context. It provides evidence for how further cases of TT may disrupt the construction industry in terms of new business models or companies from the diverse field entering the market.
Accountability and Control Over Autonomous Weapon Systems: A Framework for Comprehensive Human Oversight
Authors: Verdiesen Ilse , Santoni de Sio Filippo , Dignum Virginia 
Published: August 2020

AbstractAccountability and responsibility are key concepts in the academic and societal debate on Autonomous Weapon Systems, but these notions are often used as high-level overarching constructs and are not operationalised to be useful in practice. “Meaningful Human Control” is often mentioned as a requirement for the deployment of Autonomous Weapon Systems, but a common definition of what this notion means in practice, and a clear understanding of its relation with responsibility and accountability is also lacking. In this paper, we present a definition of these concepts and describe the relations between accountability, responsibility, control and oversight in order to show how these notions are distinct but also connected. We focus on accountability as a particular form of responsibility—the obligation to explain one’s action to a forum—and we present three ways in which the introduction of Autonomous Weapon Systems may create “accountability gaps”. We propose a Framework for Comprehensive Human Oversight based on an engineering, socio-technical and governance perspective on control. Our main claim is that combining the control mechanisms at technical, socio-technical and governance levels will lead to comprehensive human oversight over Autonomous Weapon Systems which may ensure solid controllability and accountability for the behaviour of Autonomous Weapon Systems. Finally, we give an overview of the military control instruments that are currently used in the Netherlands and show the applicability of the comprehensive human oversight Framework to Autonomous Weapon Systems. Our analysis reveals two main gaps in the current control mechanisms as applied to Autonomous Weapon Systems. We have identified three first options as future work for the design of a control mechanism, one in the technological layer, one in the socio-technical layer and one the governance layer, in order to achieve comprehensive human oversight and ensure accountability over Autonomous Weapon Systems.
Imaging plant responses to water deficit using electrical resistivity tomography
Authors: Rao Sathyanarayan , Lesparre Nolwenn , Flores-Orozco Adrián , Wagner Florian , Kemna Andreas , Javaux Mathieu 
Published: August 2020

AbstractBackground and aimsMonitoring root water uptake dynamics under water deficit (WD) conditions in fields are crucial to assess plant drought tolerance. In this study, we investigate the ability of Electrical Resistivity Tomography (ERT) to capture specific soil water depletion induced by root water uptake.MethodsA combination of surface and depth electrodes with a high spatial resolution (10 cm) was used to map 2-D changes of bulk soil electrical conductivity (EC) in an agronomic trial with different herbaceous species. A synthetic experiment was performed with a mechanistic model to assess the ability of the electrode configuration to discriminate abstraction patterns due to roots. The impact of root segments was incorporated in the forward electrical model using the power-law mixing model.ResultsThe time-lapse analysis of the synthetic ERT experiment shows that different root water uptake patterns can be delineated for measurements collected under WD conditions but not under wet conditions. Three indices were found (depletion amount, maximum depth, and spread), which allow capturing plant-specific water signatures based moisture profile changes derived from EC profiles. When root electrical properties were incorporated in the synthetic experiments, it led to the wrong estimation of the amount of water depletion, but a correct ranking of plants depletion depth. When applied to the filed data, our indices showed that Cocksfoot and Ryegrass had shallower soil water depletion zones than white clover and white clover combined with Ryegrass. However, in terms of water depletion amount, Cocksfoot consumed the largest amount of water, followed by White Clover, Ryegrass+White Clover mixture, and Ryegrass.ConclusionERT is a well-suited method for phenotyping root water uptake ability in field trials under WD conditions.
Does the availability of orthography support L2 word learning?
Authors: Krepel Alexander , de Bree Elise H. , de Jong Peter F. 
Published: August 2020

AbstractAvailability of orthography during word learning has been found to facilitate learning the word’s spelling and pronunciation and has been proposed to facilitate learning its meaning. This has not been studied in second language (L2) learning yet, in which word learning often corresponds to translation learning. Therefore, an L2 word learning experiment was carried out. Grade 6 Dutch students (n = 92) were taught English words, with orthography available or absent. Words were divided into those that are spelled entirely like they sound (consistent, e.g., lilt) and those that are not (inconsistent, e.g., budgie). Students learned the words using forward translation (Dutch to English) or backward translation (English to Dutch). At post-test spelling, reading and forward as well as backward translation were measured. Results indicate that availability of orthography mainly facilitated word spelling and reading. There was a trend for orthography to affect learning the translation. Learning consistent words benefited most from orthography, especially when the post-test demanded forward translation. As forward translation requires retrieval of the word’s pronunciation, it is likely that students used orthographic mapping to better remember the pronunciations of the English words. Forward translation was easier if words were learned in the same direction, but backward translation was not affected by learning direction. Together, these results imply that orthography supports translation learning, although this is likely caused by learning the word’s pronunciation and not by establishing a direct link between orthography and word meaning.
The ecological rationality of decision criteria
Authors: Galeazzi Paolo , Galeazzi Alessandro 
Published: August 2020

AbstractStandard evolutionary game theory investigates the evolutionary fitness of alternative behaviors in a fixed and single decision problem. This paper instead focuses on decision criteria, rather than on simple behaviors, as the general behavioral rules under selection in the population: the evolutionary fitness of classic decision criteria for rational choice is analyzed through Monte Carlo simulations over various classes of decision problems. Overall, quantifying the uncertainty in a probabilistic way and maximizing expected utility turns out to be evolutionarily beneficial in general. Minimizing regret also finds some evolutionary justifications in our results, while maximin seems to be always disadvantaged by differential selection.
Toward neuroadaptive support technologies for improving digital reading: a passive BCI-based assessment of mental workload imposed by text difficulty and presentation speed during reading
Authors: Andreessen Lena M. , Gerjets Peter , Meurers Detmar , Zander Thorsten O. 
Published: August 2020

AbstractWe investigated whether a passive brain–computer interface that was trained to distinguish low and high mental workload in the electroencephalogram (EEG) can be used to identify (1) texts of different readability difficulties and (2) texts read at different presentation speeds. For twelve subjects we calibrated a subject-dependent, but task-independent predictive model classifying mental workload. We then recorded EEG data from each subject, while twelve texts in blocks of three were presented to them word by word. Half of the texts were easy, and the other half were difficult texts according to classic reading formulas. From each text category three texts were read at a self-adjusted comfortable presentation speed and the other three at an increased speed. For each subject we applied the predictive model to EEG data of each word of the twelve texts. We found that the resulting predictive values for mental workload were higher for difficult texts than for easy texts. Predictive values from texts presented at an increased speed were also higher than for those presented at a normal self-adjusted speed. The results suggest that the task-independent predictive model can be used on single-subject level to build a highly predictive user model of the reader over time. Such a model could be employed in a system which continuously monitors brain activity related to mental workload and adapts to specific reader’s abilities and characteristics by adjusting the difficulty of text materials and the way it is presented to the reader in real time. A neuroadaptive system like this could foster efficient reading and text-based learning by keeping readers’ mental workload levels at an individually optimal level.
The impact of particulate matter 2.5 on the risk of preeclampsia: an updated systematic review and meta-analysis
Authors: Yu Hongbiao , Yin Yangxue , Zhang Jiashuo , Zhou Rong 
Published: August 2020

AbstractThere is increasing and inconsistent evidence of a linkage between maternal exposure to particulate matter 2.5 (PM2.5) and preeclampsia. Therefore, this study was conducted to investigate this relationship. Electronic databases including PubMed, Embase, Web of Science, and Cochrane Library were searched to identify articles published from inception to March 23, 2020, which showed a correlation between PM2.5 and preeclampsia. Finally, 9 of 523 initial studies were deemed eligible for inclusion. A random effect model was adopted to calculate the standardized odds ratio (OR) and 95% confidence interval (CI). Based on potential effect modification, subgroup analyses were further performed. Meta-analysis showed that maternal exposure to PM2.5 (per 10 μg/m3 increment) elevated the risk of preeclampsia (OR = 1.32, 95% CI 1.10 to 1.58%). Compared with other pregnancy trimesters, the third trimester of pregnancy seems to be the period in which women are more susceptible to PM2.5. Significant effect modification of the correlation between PM2.5 exposure and preeclampsia according to multiple pregnancies, pregnancy stage, maternal-related disease history, and sample size was not observed. The results demonstrated that maternal exposure to PM2.5 may predispose pregnant women to develop preeclampsia, especially in the third trimester of pregnancy. Therefore, more efforts should be made to improve air quality to maintain the health of pregnant women.
Sediment distribution on the continental shelf in relation to stream inputs and contamination: hydrodynamic, chemical, mineralogical, and sedimentological characteristics (Ligurian Sea, Italy)
Authors: Cutroneo Laura , Carbone Cristina , Consani Sirio , Capello Marco 
Published: August 2020

AbstractRiver estuaries, continental shelf, and sediment contamination are closely linked from the point of view of sediment transport and diffusion that is governed by different factors such as sea waves and currents, river flows and floods, and sediment characteristics. Taking these factors into consideration, we have examined marine environmental and marine bottom sediments off the mouth of a stream to highlight the main ways of sediment and contaminant transport and diffusion on the continental shelf. For this purpose, we followed a multidisciplinary approach, studying circulation of water masses, hydrological characteristics of water column, distribution and main characteristics of sediment grain size, sediment mineralogical composition, and metal concentrations of bottom sediments. Our results allowed identifying the presence of preferential ways of sediment deposition and areas of sediment spread for the Entella Stream, as well as the origin of some metals.
Mechanical Behavior of Fresh and Tempered Martensite in a CrMoV-Alloyed Steel Explained by Microstructural Evolution and Strength Modeling
Authors: Zhou Tao , Lu Jun , Hedström Peter 
Published: August 2020

Abstract
The mechanical behavior of a wear-resistant CrMoV-alloyed martensitic steel in quenched and tempered conditions has been investigated and correlated with the microstructure. The steel has a combination of ultra-high tensile strength of 2065 MPa and total elongation of 7.4 pct in the as-quenched condition. The strength and ductility of the steel change initially during tempering and thereafter remain quite stable during tempering at either 450 °C or 550 °C. A good combination of yield strength and total elongation is achieved after tempering at 550 °C for 2 to 8 hours (about 1300 MPa and 14 pct). The evolution of the mechanical properties can be mainly related to an initial condition with high density of dislocations (in the order of 1015) and carbon in solid solution, while quite early during tempering, dislocations will start to annihilate and carbide precipitates form. On the other hand, there is a negligible evolution of the effective grain size during tempering. Modeling of the individual strengthening mechanisms and the overall yield strength is in good agreement with the tensile test results, in particular for the tempered samples. Finally, the relatively low yield strength of the fresh martensite, significantly lower than for the tempered conditions, is discussed in relation to the two available theories.
Neurobiological effects of perceived stress are different between adolescents and middle-aged adults
Authors: Wu Jingsong , Tong Horace , Liu Zhongwan , Tao Jing , Chen Lidian , Chan Chetwyn C. H. , Lee Tatia M. C. 
Published: August 2020

AbstractStress is an inevitable element of everyday living. Developmental studies suggested that adolescents are more vulnerable and sensitive to the effect of stress due to their developing brains, especially in areas related to stress perception and processing. This voxel-based morphometry study examined the association between various neurobiological markers and the level of perceived stress experienced by adolescents (n = 26) and middle-aged adults (n = 26). Our findings indicated that differences existed in the relationships between perceived stress and the structural volume of the orbitofrontal cortex (OFC) extending to the insula and amygdala. Specifically, the levels of perceived stress and the grey matter volume of the orbitofrontal cortex, the insula, and the amygdala were positively related in adolescents but negatively related for adults. Furthermore, a significant negative correlation between perceived stress and cortisol levels was observed in adults, whereas the relationship between perceived stress and cortisol levels was not significant for adolescents. Perceived stress measurement may be better than cortisol levels in terms of reflecting the emotional states of adolescents. In sum, the relationships between perceived stress and neurobiological markers were different between adolescents and middle-aged adults and thus appeared to be age dependent.