bluuebunny/crossref_metadata_2025_split huggingface dataset:
Idelalisib treatment prior to allogeneic stem cell transplantation for patients with chronic lymphocytic leukemia: a report from the EBMT chronic malignancies working party
Authors: Schetelig Johannes , Chevallier Patrice , van Gelder Michel , Hoek Jennifer , Hermine Olivier , Chakraverty Ronjon , Browne Paul , Milpied Noel , Malagola Michele , Socié Gerard , Delgado Julio , Deconinck Eric , Damaj Ghandi , Maury Sebastian , Beelen Dietrich , Quoc Stéphanie Nguyen , Shankara Paneesha , Brecht Arne , Mayer Jiri , Hunault-Berger Mathilde , Bittenbring Jörg , Thieblemont Catherine , Lepretre Stéphane , Baldauf Henning , de Wreede Liesbeth C. , Tournilhac Olivier , Yakoub-Agha Ibrahim , Kröger Nicolaus , Dreger Peter 
Published: October 2020

AbstractNo studies have been reported so far on bridging treatment with idelalisib for patients with chronic lymphocytic leukemia (CLL) prior to allogeneic hematopoietic cell transplantation (alloHCT). To study potential carry-over effects of idelalisib and to assess the impact of pathway-inhibitor (PI) failure we performed a retrospective EBMT registry-based study. Patients with CLL who had a history of idelalisib treatment and received a first alloHCT between 2015 and 2017 were eligible. Data on 72 patients (median age 58 years) were analyzed. Forty percent of patients had TP53mut/del CLL and 64% had failed on at least one PI. No primary graft failure occurred. Cumulative incidences of acute GVHD °II–IV and chronic GVHD were 51% and 39%, respectively. Estimates for 2-year overall survival (OS), progression-free survival (PFS), and cumulative incidences of relapse/progression (CIR) and non-relapse mortality NRM were 59%, 44%, 25%, and 31%. In univariate analysis, drug sensitivity was a strong risk factor. For patients who had failed neither PI treatment nor chemoimmunotherapy (CIT) the corresponding 2-year estimates were 73%, 65%, 15%, and 20%, respectively. In conclusion, idelalisib may be considered as an option for bridging therapy prior to alloHCT. Owing to the high risk for acute GVHD intensified clinical monitoring is warranted.
Benchmarking evolutionary tinkering underlying human–viral molecular mimicry shows multiple host pulmonary–arterial peptides mimicked by SARS-CoV-2
Authors: Venkatakrishnan A. J. , Kayal Nikhil , Anand Praveen , Badley Andrew D. , Church George M. , Soundararajan Venky 
Published: October 2020

AbstractThe hand of molecular mimicry in shaping SARS-CoV-2 evolution and immune evasion remains to be deciphered. Here, we report 33 distinct 8-mer/9-mer peptides that are identical between SARS-CoV-2 and the human reference proteome. We benchmark this observation against other viral–human 8-mer/9-mer peptide identity, which suggests generally similar extents of molecular mimicry for SARS-CoV-2 and many other human viruses. Interestingly, 20 novel human peptides mimicked by SARS-CoV-2 have not been observed in any previous coronavirus strains (HCoV, SARS-CoV, and MERS). Furthermore, four of the human 8-mer/9-mer peptides mimicked by SARS-CoV-2 map onto HLA-B*40:01, HLA-B*40:02, and HLA-B*35:01 binding peptides from human PAM, ANXA7, PGD, and ALOX5AP proteins. This mimicry of multiple human proteins by SARS-CoV-2 is made salient by single-cell RNA-seq (scRNA-seq) analysis that shows the targeted genes significantly expressed in human lungs and arteries; tissues implicated in COVID-19 pathogenesis. Finally, HLA-A*03 restricted 8-mer peptides are found to be shared broadly by human and coronaviridae helicases in functional hotspots, with potential implications for nucleic acid unwinding upon initial infection. This study presents the first scan of human peptide mimicry by SARS-CoV-2, and via its benchmarking against human–viral mimicry more broadly, presents a computational framework for follow-up studies to assay how evolutionary tinkering may relate to zoonosis and herd immunity.
Prenatal diagnosis of Fraser syndrome caused by novel variants of FREM2
Authors: Ikeda Shoko , Akamatsu Chika , Ijuin Akifumi , Nagashima Ami , Sasaki Megumi , Mochizuki Akihiko , Nagase Hiromi , Enomoto Yumi , Kuroda Yukiko , Kurosawa Kenji , Ishikawa Hiroshi 
Published: October 2020

AbstractFraser syndrome (FS) involves multiple malformations and has a 25% recurrence risk among siblings. However, these malformations are difficult to detect prenatally, hampering prenatal diagnosis. Here, we describe a fetus with FS diagnosed using ultrasonography. Ultrasonography revealed congenital high airway obstruction syndrome and renal agenesis. Syndactyly of both hands and cryptophthalmos were noted postnatally, and the diagnosis was confirmed by genetic analysis, which showed novel compound heterozygous variants of FREM2.
The Brazilian Initiative on Precision Medicine (BIPMed): fostering genomic data-sharing of underrepresented populations
Authors: Rocha Cristiane S. , Secolin Rodrigo , Rodrigues Maíra R. , Carvalho Benilton S. , Lopes-Cendes Iscia 
Published: October 2020

AbstractThe development of precision medicine strategies requires prior knowledge of the genetic background of the target population. However, despite the availability of data from admixed Americans within large reference population databases, we cannot use these data as a surrogate for that of the Brazilian population. This lack of transferability is mainly due to differences between ancestry proportions of Brazilian and other admixed American populations. To address the issue, a coalition of research centres created the Brazilian Initiative on Precision Medicine (BIPMed). In this study, we aim to characterise two datasets obtained from 358 individuals from the BIPMed using two different platforms: whole-exome sequencing (WES) and a single nucleotide polymorphism (SNP) array. We estimated allele frequencies and variant pathogenicity values from the two datasets and compared our results using the BIPMed dataset with other public databases. Here, we show that the BIPMed WES dataset contains variants not included in dbSNP, including 6480 variants that have alternative allele frequencies (AAFs) >1%. Furthermore, after merging BIPMed WES and SNP array data, we identified 809,589 variants (47.5%) not present within the 1000 Genomes dataset. Our results demonstrate that, through the incorporation of Brazilian individuals into public genomic databases, BIPMed not only was able to provide valuable knowledge needed for the implementation of precision medicine but may also enhance our understanding of human genome variability and the relationship between genetic variation and disease predisposition.
Toward improved trade-off between thermoelectric and mechanical performances in polycarbonate/single-walled carbon nanotube composite films
Authors: Zhang Yichuan , Deng Liang , Lv Haicai , Chen Guangming 
Published: October 2020

AbstractPolymer thermoelectric (TE) composites have witnessed explosive developments in recent years, arising from their promising prospect for lightweight flexible electronics and capability of harvesting waste-heat. In sharp contrast with intrinsically conducting polymers (CPs), the insulating thermoplastics have seldom been employed as the matrices for flexible TE composites despite their advantages of low costs, controllable melt-flowing behaviors and excellent mechanical properties. Here, we report flexible films of polycarbonate/single-walled carbon nanotube (PC/SWCNT) composites with improved trade-off between TE and mechanical performances. The SWCNTs with 1D nanostructure were dramatically aligned by PC melt-flowing under hot-pressing in the radial direction. The composite maximum power factor reaches 4.8 ± 0.8 μW m−1 K−2 at 10 wt% SWCNTs in the aligned direction, which is higher than most previously reported thermoplastics-based TE composites at the same SWCNT loading and even comparable to some intrinsically CPs and their composites. In addition, these composites display significantly higher tensile modulus and strength than CPs and their composites. This study paves an effective way to fabricate flexible films of polymer composites with simultaneously high TE and mechanical performances via judicious alignment of SWCNTs in thermoplastic polymers.
Morphological and nanomechanical changes in tungsten in high heat flux conditions
Authors: Seo Minsuk , Echols John R. , Winfrey A. Leigh 
Published: October 2020

AbstractMorphological and nanomechanical alteration of tungsten in extreme environments, like those in edge localized modes in nuclear fusion environments, up to 46.3 GWm−2 heat fluxes were experimentally simulated using electrothermal plasma. Surface and subsurface damage to the tungsten is seen mainly in the form of pore formation, cracks, and resolidified melt instabilities. Mirco voids, rosette-type microfeatures, core-shell structure, particle enrichment, and submicron channels all manifest in the damaged subsurface. The formation of voids in the subsurface was determined to originate from the ductile fracture of hot tungsten by plastic flow but not developed to cracking. The voids were preferentially settled in grain boundaries, interfaces. The directionality of elongated voids and grains is biased to the heat flow vector or plasma pathway, which is the likely consequence of the thermally driven grain growth and sliding in the high-temperature conditions. The presence of a border between the transient layer and heat-affected zone is observed and attributed to plasma shock and thermal spallation of fractural tungsten at high temperature. Plasma peening-like hardening effects in tungsten were observed in the range of 22.7–46.3 GWm−2 but least in the case of the lowest heat flux, 12.5 GWm−2.
The prototype device for non-invasive diagnosis of arteriovenous fistula condition using machine learning methods
Authors: Grochowina Marcin , Leniowska Lucyna , Gala-Błądzińska Agnieszka 
Published: October 2020

AbstractPattern recognition and automatic decision support methods provide significant advantages in the area of health protection. The aim of this work is to develop a low-cost tool for monitoring arteriovenous fistula (AVF) with the use of phono-angiography method. This article presents a developed and diagnostic device that implements classification algorithms to identify 38 patients with end stage renal disease, chronically hemodialysed using an AVF, at risk of vascular access stenosis. We report on the design, fabrication, and preliminary testing of a prototype device for non-invasive diagnosis which is very important for hemodialysed patients. The system includes three sub-modules: AVF signal acquisition, information processing and classification and a unit for presenting results. This is a non-invasive and inexpensive procedure for evaluating the sound pattern of bruit produced by AVF. With a special kind of head which has a greater sensitivity than conventional stethoscope, a sound signal from fistula was recorded. The proces of signal acquisition was performed by a dedicated software, written specifically for the purpose of our study. From the obtained phono-angiogram, 23 features were isolated for vectors used in a decision-making algorithm, including 6 features based on the waveform of time domain, and 17 features based on the frequency spectrum. Final definition of the feature vector composition was obtained by using several selection methods: the feature-class correlation, forward search, Principal Component Analysis and Joined-Pairs method. The supervised machine learning technique was then applied to develop the best classification model.
A confocal Raman microscopic visualization of small penetrants in cellulose acetate using a deuterium-labeling technique
Authors: Kubota Hiroyuki , Sakamoto Koji , Matsui Toshiro 
Published: October 2020

AbstractThe purpose of the present study was to visualize the sorption dynamics of small compounds, such as propylene glycol (PG) in cellulose acetate (CA) film, by deuterium (d) labeling-aided confocal Raman spectroscopy (CRM). Substitution of hydrogen atoms in the target molecule with deuterium caused a marked shift of C-H bond-related Raman bands to low wavenumbers, while the number of deuterium did not affect the magnitude of the shift. Raman bands derived from the stretching vibration of C–H near 2900 cm−1for PG and ethanol were shifted to approximately 2100 cm−1for PG-d6 and ethanol-d5 in the silent region of the CA Raman spectrum. When PG-d6 was dissolved in glycerol triacetate (GTA), the observed Raman intensity ratio at 2123 cm−1of PG-d6 against 1739 cm−1of GTA (C=O bond-related) showed a linear relationship between the molar and intensity ratios, indicating that the observed Raman intensity can be used for quantitative assay of the target in polymer film. The depth profiling experiments by CRM revealed that the distribution (or sorption) of PG-d6 in CA film was successfully visualized as a function of Raman band at the characteristic 2123 cm−1intensity ratio.
Visible light mediated photocatalytic [2 + 2] cycloaddition/ring-opening rearomatization cascade of electron-deficient azaarenes and vinylarenes
Authors: Salaverri Noelia , Mas-Ballesté Rubén , Marzo Leyre , Alemán José 
Published: October 2020

AbstractThe broad presence of azaarene moieties in natural products has promoted the development of new functionalization reactions, giving access to larger libraries of bioactive compounds. The light promoted [2 + 2] photocycloaddition reaction to generate cyclobutanes has been extensively studied in photochemistry. In particular, De Mayo reported the [2 + 2] cycloaddition followed by retroaldol condensation between enols of 1,3-dicarbonyls and double bonds to synthesize 1,5-dicarbonyls. Herein, we describe the [2 + 2] photocycloaddition followed by a ring-opening rearomatization reaction between electron-deficient 2-methylene-azaarenes and double bonds, taking advantage of the ability of these heterocyclic derivatives to form the corresponding pseudo-enamine intermediate. The procedure shows a high functional group tolerance either on the double bond or the heteroarene side and allows the presence of different electron-withdrawing groups. In addition, the wide applicability of this reaction has been demonstrated through the late-stage derivatization of several natural products. Photochemical studies, together with theoretical calculations, support a mechanism involving the photosensitization of the pseudo-enamine intermediate.
Elevated Circulating LINC-P21 Serves as a Diagnostic Biomarker of Type 2 Diabetes Mellitus and Regulates Pancreatic β-cell Function by Sponging miR-766-3p to Upregulate NR3C2
Authors: Cao Zhibin , Yao Fuwang , Lang Yuqin , Feng Xueqiang 
Published: October 2020

Abstract
Objective The purpose of this study was to evaluate the clinical value and biological function of long non-coding RNA (lncRNA) LINC-P21 in type 2 diabetes mellitus (T2DM), and explore the underlying mechanisms.
Methods The expression of LINC-P21 was estimated using quantitative real-time PCR. The functional role of LINC-P21 was explored by gain- and loss-of-function experiments. INS-1 cell proliferation was analyzed using a cell counting kit-8 (CCK-8)assay, and the glucose-stimulated insulin secretion was measured using an ELISA kit. The miRNAs that might be sponged by LINC-P21 were analyzed, and the subsequent target genes were predicted and assessed in INS-1 cells.
Results Serum expression of LINC-P21 was elevated in T2DM patients, which was correlated with fasting blood glucose levels and disease diagnosis. The glucose-stimulated insulin secretion and the proliferation of INS-1 cells were enhanced by LINC-P21 knockdown, but the overexpression of LINC-P21 led to opposite effects. miR-766-3p could be directly inhibited by LINC-P21 in INS-1 cells and reverse the effects of LINC-P21 on β-cell function. Additionally, NR3C2 was determined as a target of miR-766-3p, which could be positively regulated by LINC-P21 and had same effects with LINC-P21 on INS-1 cell proliferation and insulin secretion.
Conclusion All the data demonstrated that serum elevated LINC-P21 and decreased miR-766-3p serve as candidate diagnostic biomarkers in T2DM patients. LINC-P21 acts as a potential regulator in insulin secretion and proliferation of pancreatic β-cells through targeting miR-766-3p to upregulate NR3C2.
Avaliação da concordância interobservador das classificações de Fraser e Blake & McBryde para joelho flutuante
Authors: Alencar Neto Jonatas Brito , Osório Neto Ernane Bruno , Souza Clodoaldo José Duarte de , da Rocha Pedro Henrique Messias , Cavalcante Maria Luzete Costa , Lopes Márcio Bezerra Gadelha 
Published: October 2020

Resumo
Objetivo Avaliar a concordância interobservador de duas classificações para joelho flutuante: Fraser e Blake & Mcbryde.
Método Trinta e dois observadores, subdivididos de acordo com o grau de titulação (26 médicos residentes e seis médicos ortopedistas especialistas em trauma ortopédico) classificaram 15 fraturas de fêmur e tíbia ipsilaterais. A concordância interobservador foi avaliada pelo coeficiente Kappa.
Resultado Ao avaliar a concordância entre os 9 R1, obteve-se índice Kappa para classificação de Fraser de 0,58 e para a classificação de Blake & McBryde de 0,46. Entre os 7 R2, obteve-se índice de 0,59 para a classificação de Fraser e 0,51 para a classificação de Blake & McBryde. Entre os 10 R3, o índice de concordância foi maior para as duas classificações: 0,72 para a classificação de Fraser e 0,71 para a de Blake & McBryde. Considerando os 3 grupos (R1, R2, R3) como um só grande grupo, calculou-se o índice Kappa geral, que teve como resultado 0,63 para a classificação de Fraser e 0,56 para a classificação de Blake & McBryde. No grupo dos traumato-ortopedistas especialistas em joelho, por sua vez, obteve-se uma concordância para a classificação de Blake e McBryde de 0,597 e para a de Fraser de 0,843.
Conclusão Comparativamente, as duas classificações apresentaram grau de concordância fraco a moderado. A classificação de Fraser teve melhor concordância em ambos os grupos. A concordância foi maior quando se avaliou médicos ortopedistas especialistas em trauma ortopédico.
Fractura del tubérculo medial de la apófisis posterior del astrágalo
Authors: García-Ortiz María Tíscar , Moril-Peñalver Lorena , Sevilla-Monllor Alexandra , Fernández-Ruiz María Dolores , Menchi-Elanzi Issam , López-Prats Fernando 
Published: October 2020

Resumen
Objetivo Mostrar una fractura infrecuente del tubérculo posteromedial del astrágalo diagnosticado y tratado de manera aguda mediante osteosíntesis con tornillo Acutrak® (2014 Acumed® LLC).
Material y Métodos Varón de 28 años, que acude a Urgencias tras torcedura de tobillo con dolor al mover tobillo y hallux y tumefacción en cara interna. En Urgencias pasó desapercibida. En consulta a la semana refería sensación de que se le engancha el primer dedo con la flexoextensión. Se observa fractura del tubérculo medial de la apófisis posterior del astrágalo con desplazamiento >3mm y clínica de posible interposición del flexor hallucis longus. Se decidió tratamiento quirúrgico con tornillo Acutrak®. Se inmovilizó con férula 3 semanas y descarga 6 semanas.
Resultados A los 8 meses balance articular completo, sin dolor ni limitación para las ABVD y sin clínica de atrapamiento del flexor del hallux. Como complicación aguda, se verificó infección de herida quirúrgica que se trató con antibióticos.
Discusión Ese tipo de fracturas son infrecuentes. El mecanismo lesional suele ser dorsiflexión-pronación. Es importante un diagnóstico temprano y para ello es necesario una alta sospecha diagnóstica. Para su diagnóstico, son necesarias radiografías anteroposterior y lateral y si no se visualiza la lesión, proyección oblicua con 30°- 40° de rotación externa. En casos agudos resulta de utilidad la TAC y en casos crónicos la RM.
Conclusión Aunque generalmente el tratamiento es conservador, en ocasiones puede ser necesario la cirugía mediante osteosíntesis o exéresis del fragmento cuando la fractura provoca impingement.
Electrode materials based on complex d-metal oxides for symmetrical solid oxide fuel cells
Authors: Istomin Sergey Ya. , Lyskov Nikolay V. , Mazo Galina N. , Antipov Evgeny V. 
Published: October 2020

The review addresses and highlights the main results of research on the physicohemical properties of single-phase and composite materials based on transition metal oxides in relation to their practical application as electrode materials for symmetrical solid oxide fuel cells. The electronic structures and thermodynamic stability of transition metal oxides with the perovskite structure are discussed. A detailed consideration is given to the thermal behaviour, chemical stability, electrical conductivity and electrochemical properties of a broad range of electrode materials based on iron-, chromium- and manganese-containing perovskite-like oxides and oxides that crystallize in other structure types. The analysis revealed the most promising compositions of electrode materials for symmetrical solid oxide fuel cells and effective approaches to the improvement of their functional characteristics.
The bibliography includes 202 references.
Fruit development and postharvest physiology.
Authors: Hancock James F. 
Published: October 2020

Abstract

This chapter focuses on the fruiting and postharvest physiology of strawberries and includes a new section on strawberry nutrition. Information is provided on the nutritional benefits, physiological and environmental factors influencing fruit growth, fruit ripening, components of flavour and aroma, handling and storage of fresh fruit, handling of processed fruit, and genetic regulation of fruit development.
Strain relaxation dynamics of multiferroic orthorhombic manganites
Authors: Carpenter M A , Pesquera D , O’Flynn D , Balakrishnan G , Mufti N , Nugroho A A , Palstra T T M , Mihalik M , Mihalik M , Zentková M , Almeida A , Moreira J Agostinho , Vilarinho R , Meier D 
Published: October 2020

Abstract
Resonant ultrasound spectroscopy has been used to characterise strain coupling and relaxation behavior associated with magnetic/magnetoelectric phase transitions in GdMnO3, TbMnO3 and TbMn0.98Fe0.02O3 through their influence on elastic/anelastic properties. Acoustic attenuation ahead of the paramagnetic to colinear-sinusoidal incommensurate antiferromagnetic transition at ∼41 K correlates with anomalies in dielectric properties and is interpreted in terms of Debye-like freezing processes. A loss peak at ∼150 K is related to a steep increase in electrical conductivity with a polaron mechanism. The activation energy, E
a, of ≳0.04 eV from a loss peak at ∼80 K is consistent with the existence of a well-defined temperature interval in which the paramagnetic structure is stabilised by local, dynamic correlations of electric and magnetic polarisation that couple with strain and have relaxation times in the vicinity of ∼10−6 s. Comparison with previously published data for Sm0.6Y0.4MnO3 confirms that this pattern may be typical for multiferroic orthorhombic RMnO3 perovskites (R = Gd, Tb, Dy). A frequency-dependent loss peak near 10 K observed for TbMnO3 and TbMn0.98Fe0.02O3, but not for GdMnO3, yielded E
a ⩾ ∼0.002 eV and is interpreted as freezing of some magnetoelastic component of the cycloid structure. Small anomalies in elastic properties associated with the incommensurate and cycloidal magnetic transitions confirm results from thermal expansion data that the magnetic order parameters have weak but significant coupling with strain. Even at strain magnitudes of ∼0.1–1‰, polaron-like strain effects are clearly important in defining the development and evolution of magnetoelectric properties in these materials. Strains associated with the cubic–orthorhombic transition due to the combined Jahn–Teller/octahedral tilting transition in the vicinity of 1500 K are 2–3 orders of magnitude greater. It is inevitable that ferroelastic twin walls due to this transition would have significantly different magnetoelectric properties from homogeneous domains due to magnetoelastic coupling with steep strain gradients.