bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altersbedingte Makuladegeneration und Omega-3
Authors: Schmiedel Volker 
Published: July 2020

ZusammenfassungDie altersbedingte Makuladegeneration (AMD) ist eine Erkrankung der Netzhaut des Auges, die zu einem Funktionsverlust des Sehens bis hin zur Blindheit führen kann. Es gibt nur wenige therapeutische Ansätze (z. B. photodynamische Therapie, Biologicals), die aufwändig und teuer sind. Vor einigen Jahren konnte der Nutzen von Antioxidanzien bewiesen werden, wobei den Carotinoiden Lutein und Zeaxanthin eine besondere Bedeutung zukommt. Mittlerweile gibt es aber auch epidemiologische und interventionelle Studien zu Omega-3-Fettsäuren in der Prävention und Therapie der AMD.
Chubby Infant – Should One Worry? An Infant with Primary
lymphedema – Mini Review and Case Report
Authors: Kaczmarek Joanna Magdalena , Graczykowska Karolina Anna , Szymkuć-Bukowska Iwona , Łoś-Rycharska Ewa , Krogulska Aneta 
Published: July 2020

AbstractLymphedema is a localized form of tissue swelling, characterized by a progressive
accumulation of a tissue fluid in the interstitial compartment as a result of
the lymphatic system dysfunction. It is a rare disease in the pediatric
population and in the majority of cases it is a consequence of an abnormal
formation of the lymphatic system, which is called primary lymphedema. Although
its epidemiology is not precise, it is assumed that 1:100 000 children suffer
from primary lymphedema. The diagnosis can be made by a proper clinical
examination after ruling out secondary causes of lymphedema, particularly in
cases with a more asymmetric swelling of the extremities. In this very article
we present a case report of an 8-months-old infant with primary lymphedema, who
had presented swelling of the extremities from birth and yet no pathology was
suspected before. The purpose of this article is to draw attention to the fact
that a baby with excessive subcutaneous tissue is not always a healthy, chubby
infant with considerable amount of fat tissue.
Die Videosprechstunde im Geltungsbereich der gesetzlichen Krankenversicherung – Umsetzungs-, Verbreitungs- und Entwicklungsmöglichkeiten aus Patientensicht
Authors: Mittmann Christian , Becker Kurt , Hoffmann Felix 
Published: July 2020

Zusammenfassung
Zielsetzung Im Rahmen dieser Studie wurden die Anforderungen an Videosprechstunden aus Patientensicht untersucht, um anhand dessen Maßnahmen herauszuarbeiten, welche die Videosprechstunde als Bestandteil der ambulanten Versorgung etablieren können.
Methodik Die Fragestellung wurde anhand einer qualitativen Befragung bearbeitet.
Ergebnisse Im Rahmen der Interviews zeigte sich, dass die Inanspruchnahme einer Videosprechstunde vor allem bei geringfügigen Anlässen für eine zeitsparende Konsultation des Arztes und damit einhergehender Bescheinigungen in Betracht gezogen wird.Aus den Ergebnissen dieser Studie lässt sich ableiten, dass die geringe Nutzung der Videosprechstunde eher dem geringenAngebot und nicht der fehlenden Teilnahmebereitschaft geschuldet ist.
Schlussfolgerung Die Fortentwicklung der Videosprechstunde sollte drei Aspekte berücksichtigen.Erstens sollte die Videosprechstunde durch gezielte und ausgewogene Marketingaktionen bekannter gemacht werden. Hierbei handelt es sich zunächst um eine Push-Strategie, bei der die Nachfrage dem Angebot folgt. Wenn die Videosprechstunde einmal weitläufig etabliert ist, kann dies auch zu einem steigenden Anreiz für niedergelassene Ärzte führen, die Videosprechstunde anzubieten.Zweitens sollten Ärzte adressiert und die Etablierung von Videosprechstunden im Praxis- oder Klinikbetrieb attraktiver gemacht werden. Maßgeblich dazu beitragen dürfte eine Vergütung, die die Online-Visiten gegenüber den regulären Sprechstunden nicht benachteiligt.Drittens sollte die Videosprechstunde als Subjekt im Spannungsfeld von Digitalisierung und E-Health weiterentwickelt werden und die Entwicklung der Digitalisierung insgesamt als ganzheitliches Konzept forciert werden.
Same Day versus Staged Total Knee Arthroplasty: Do Cost Savings Justify the Risk?
Authors: Wilkie Wayne , Mohamed Nequesha , Remily Ethan , Pastore Mark , Nace James , Delanois Ronald E. 
Published: July 2020

AbstractSame-day bilateral total knee arthroplasties (BTKAs) are associated with increased complications compared with staged procedures; however, as complication rates and lengths of stay (LOS) for same-day procedures decrease, they may become attractive alternatives to staged procedures. The void of recent nationwide studies comparing the 30-day total cost and risks of these procedures inspired this propensity matched review. Therefore, we compared 30-day outcomes in staged and same-day BTKAs occurring in 2016 and 2017 using the National Readmission Database (NRD), a nationwide database. The NRD was queried for all same-day and staged BTKA patients from January 1 to November 30 for both 2016 and 2017. Since the NRD links readmissions within one calendar year, TKAs occurring in this month were excluded to allow 30-day follow-up. Propensity matching was performed based on demographics, producing 19,334 patients in both cohorts. Thirty-day readmission, revision, and mortality rates, hospital costs, LOS, discharge dispositions, and complications were analyzed. Chi-square and Student's t-tests assessed categorical and continuous variables, respectively. A p-value of <0.05 was set as the threshold for statistical significance. The analysis demonstrated that less same-day patients were readmitted, with statistical but not clinical difference in revisions, and mortality (all p < 0.050). Higher 30-day cost ($33,522 vs. $29,053, p < 0.001), decreased total LOS (4.52 vs. 4.94 days, p < 0.001), and lower rates of PEs (0.3 vs. 1.1%, p < 0.001) and transfusions (2.1 vs. 8.5%, p < 0.001) but similar total complications (p >0.050) were associated staged compared with same-day BTKAs. The results suggest inpatient cost savings associated with same-day surgeries should be weighed against the slight increase in LOS and PEs. Ultimately, as LOS and PE rates continue to decrease from innovations and quality improvements, same-day BTKA may become an attractive alternative to staged BTKAs, especially if payer's incentive surgeons by increasing physician reimbursements.
The Influence of Posterior Cruciate Ligament Resection on Tibiofemoral Joint Gap in Varus Osteoarthritic Knees
Authors: Oshima Yasushi , Majima Tokifumi , Iizawa Norishige , Hoshikawa Naoya , Takahashi Kenji , Takai Shinro 
Published: July 2020

AbstractPosterior cruciate ligament (PCL) resection during posterior-stabilized total knee arthroplasty (PS-TKA) has been reported to preferentially increase the tibiofemoral joint gap in flexion compared with extension. However, previous assessments of the joint gaps have been performed after bone resection and medial soft tissue release. Thus, these procedural steps may have the potential to influence soft tissue balance. In native knees, soft tissue laxity is generally greater in the lateral compartment than in the medial compartment both with the knee in extension and in flexion. Some surgeons may retain this natural soft tissue balance with less aggressive medial release during TKA. We performed this study to evaluate the impact of the PCL resection on the extension and flexion gaps in the absence of bone resection or medial soft tissue release. Tibiofemoral joint gaps for 41 patients (10 males and 31 females) in full extension and at 90 degrees of flexion both before and after the resections of both the anterior cruciate ligament (ACL) and PCL were assessed using a ligament tensioner device. The statistical analyze was performed using the Mann–Whitney U test. The results showed that medial gap in extension and flexion were 6.7 ± 1.0 and 7.3 ± 0.9 mm, and lateral gap in extension and flexion were 7.6 ± 1.1 and 8.4 ± 1.6 mm, respectively. Thus, physiological tibiofemoral gaps just after knee arthrotomy were trapezoidal and asymmetric shape with the significantly wider gaps in lateral and flexion, compared with the medial and extension, respectively (p < 0.05). However, the increases of the gaps with the ACL and PCL resections were less than 1 mm under the existence of medial soft tissues. As the medial collateral ligament is the primary restraint for the valgus instability, it was also considered to prevent the increase of the flexion gap although the PCL—which is the secondary restraint for the valgus instability—was resected. This finding is critically important for orthopedic surgeons applying PS-TKA implants, particularly for preserving soft tissues to achieve natural knee kinematics postoperatively.
Tear Rates of the Ipsilateral ACL Graft and the Contralateral Native ACL Are Similar following ACL Reconstruction
Authors: Ifran Nadia Nastassia , Mok Ying Ren , Krishna Lingaraj 
Published: July 2020

AbstractThe aim of the study is to compare the tear rates of ipsilateral anterior cruciate ligament (ACL) grafts and the contralateral native ACL as well as to investigate the correlation of gender, age at time of surgery, and body mass index (BMI) with the occurrence of these injuries. The medical records of 751 patients who underwent ACL reconstruction surgery with follow-up periods of 2 to 7 years were retrospectively analyzed. Survival analyses of ipsilateral ACL grafts and contralateral native ACL were performed. Univariate and multivariate logistic regression analyses were performed to identify risk factors that were associated with these injuries. The tear rates of the ipsilateral ACL graft and contralateral ACL were 5.86 and 6.66%, respectively with no significant difference between groups (p = 0.998). The mean time of tears of the ipsilateral ACL and contralateral ACL was also similar (p = 0.977) at 2.64 and 2.78 years, respectively after surgery. Both the odds of sustaining an ipsilateral ACL graft and contralateral ACL tear were also significantly decreased by 0.10 (p = 0.003) and 0.14 (p = 0.000), respectively, for every 1-year increase in age at which the reconstruction was performed. However, graft type, gender, and BMI were not associated with an increased risk of these injuries. There was no difference between tear rates of ipsilateral ACL graft and contralateral ACL following ACL reconstruction. Patients who undergo ACL reconstruction at a young age are at an increased risk of both ipsilateral graft and contralateral ACL rupture after an ACL reconstruction. Patients who are young and more likely to return to competitive sports should be counselled of the risks and advised to not neglect the rehabilitation of the contralateral knee during the immediate and back to sports period of recovery. This is a Level III, retrospective cohort study.
Obesity Does Not Affect Patient-Reported Outcomes following Patellofemoral Arthroplasty
Authors: Tishelman Jared C. , Pyne Abigail , Kahlenberg Cynthia A. , Gruskay Jordan A. , Strickland Sabrina M. 
Published: July 2020

AbstractPatellofemoral arthroplasty (PFA) has garnered attention in recent years as an effective alternative to total knee arthroplasty for patients with symptomatic, isolated patellofemoral joint arthritis. Obesity has previously been identified as a risk factor for revision surgery, but its effect on patient-reported outcome measures (PROMs) has not been evaluated. A retrospective review of a consecutive series of PFA surgeries was conducted at a single, specialized orthopedics center in a major urban center. Patients were dichotomized by body mass index (BMI) as obese (O, BMI >30) or nonobese (NO, BMI: 18.5–25). Demographic, surgical information, and PROMs were collected and analyzed accordingly. Seventy-six patients (41 nonobese, 35 obese) were identified. Patients who were obese presented with significantly worse preoperative PROMs regarding knee-specific quality of life, physical function, and MH or mental health (knee injury and osteoarthritis outcome score quality of life [KOOS QoL], NO: 26.2, O: 14.7, p = 0.019; KOOS PF, NO: 38.2, O: 50.5, p = 0.002; Veterans Rand-12 mental health [VR-12 MH], NO: 54.2, O: 47.0, p = 0.033). No significant difference was seen in improvement in knee function scores between patients who were obese or nonobese (KOOS QoL, NO: 39.5, O: 40.6, p = 0.898; KOOS PS [physical function], NO: –17.8, O: –17.3, p = 0.945). Additionally, no difference in the rate of PFA revision was observed and there were no postoperative complications reported. Obese patients with isolated PFA can expect the same improvement in function as nonobese patients following patellofemoral joint arthroplasty. This paper underscores the priority of patient selection in PFA and challenges the notion that surgeons should exclude patients from receiving a PFA on the basis of obesity.
Comparison between Mid-Term Results of Total Knee Arthroplasty with Single-Radius versus Multiple-Radii Posterior-Stabilized Prostheses
Authors: Luo Zhenyu , Zhou Kai , Wang Haoyang , Pei Fuxing , Zhou Zongke 
Published: July 2020

AbstractSingle-radius (SR) prostheses and multiple-radii (MR) prostheses have different theoretical advantages; however, few comparative studies have been reported. The aim of the study was to compare mid-term clinical, radiological, and survival outcomes of SR and MR posterior-stabilized prostheses in total knee arthroplasty (TKA). Two hundred consecutive patients who underwent TKA between January 2012 and July 2013 were enrolled in the SR group (100 patients) and an MR group (100 patients), with a minimum follow-up of 5 years. Functional, radiological, satisfaction, and survival rates were evaluated. There was a significantly higher range of motion (ROM) in the SR group than in the MR group (flexion, 123.65 ± 10.12 degrees vs. 115.52 ± 10.03 degrees, p < 0.001). Quadriceps strength (3.05 ± 0.43 vs. 2.68 ± 0.58 kg, p = 0.025) and chair test results (80 [93.02%] vs. 69 [83.13%], p = 0.027) were better in the SR group than in the MR group. The SR group also had significantly less anterior knee pain (6 [6.98%] vs. 15 [18.07%], p < 0.05) and a better satisfaction rate than those in the MR group. No significant differences were observed in clinical scale scores such as Hospital for Special Surgery (HSS), Knee Society Score (KSS), and Short-Form 12 (SF-12), radiological results in terms of component position and radiolucent lines. The Kaplan–Meier survival curve estimates at 5 years were not significantly different (96.91% [95% confidence interval [CI]: 93.5–99.5%] vs. 94.86% [95% CI: 90.6–98.6%], p = 0.4696). The SR prosthesis design was better than that of the MR in terms of ROM, reduced anterior knee pain, contributions to better recovery of the extension mechanism, and higher satisfaction rates. The SR had similar results in clinical scales such as HSS, KSS, SF-12, radiological, or survival results to MR prostheses. More accurate measurements and longer-term follow-up are required.
Valency coercion in Italian
Authors: Busso Lucia , Lenci Alessandro , Perek Florent 
Published: July 2020

AbstractThe paper investigates valency coercion effects in Italian by means of an acceptability rating task on nine argument structure constructions. The experimental design followsPerek & Hilpert (2014)in presenting three conditions: grammatical, impossible and coercion stimuli. This design allows us to test several factors: the acceptability of creative coerced structures, the role of age and – most importantly – the influence of the construction itself. Results overall confirm our hypotheses: valency coercion is identified as an intermediate level between grammaticality and ungrammaticality, with varying degrees of “coercibility” across constructions. An influence of age is not in evidence for coercion sentences, suggesting that the systematic variation in acceptability is due to the influence of different constructions. We propose that coercion resolution results from the interaction of constructional and lexical semantics.
Moving Time vs. Frame-relative motion
Authors: Moore Kevin Ezra 
Published: July 2020

Abstract
There is an elaborate analogy between Moving Time (composed of primary metaphors; e.g. Christmas is
approaching) and Frame-relative Fictive Motion (e.g. Your destination is approaching). It has been
suggested that this analogy could be involved in the motivation of Moving Time. However, a semantic frame analysis that includes
all stages of the motion event shows that this analogy could not be involved in the motivation of Moving Time. It is further
argued that Moving Time and Frame-relative Fictive Motion are instances of different types of cognitive-semantic structure. Moving
Time is a selective integration of concepts from frames that do not share elements with each other, whereas Frame-relative Fictive
Motion presupposes a single semantic frame. For the purpose of distinguishing fictive motion from primary metaphor (e.g. Moving
Time), Coextension-path and Pattern-path fictive motion are studied in addition to Frame-relative. These three types of fictive
motion can be distinguished from primary metaphor because they involve the integration of concepts from frames that share specific
structure, whereas primary metaphor involves frames that do not share specific structure.
In a preliminary classification of fictive motion as a type of metaphor, all three types of fictive motion
discussed may be classified as resemblance-based metaphors. Coextension-path and Frame-relative fictive motion are also motivated
by correlations in experience. These correlations, however, are different in kind from those that motivate primary metaphor.
High transmission from 2D periodic plasmonic finite arrays with sub-20 nm gaps realized with Ga focused ion beam milling
Authors: Pisano Filippo , Balena Antonio , Kashif Muhammad Fayyaz , Pisanello Marco , de Marzo Gaia , Algieri Luciana , Qualtieri Antonio , Sileo Leonardo , Stomeo Tiziana , D’Orazio Antonella , De Vittorio Massimo , Pisanello Ferruccio , Grande Marco 
Published: July 2020

Abstract
Fabricating plasmonic nanostructures with good optical performances often requires lengthy and challenging patterning processes that can hardly be transferred to unconventional substrates, such as optical fiber tips or curved surfaces. Here we investigate the use of a single Ga focused ion beam process to fabricate 2D arrays of gold nanoplatelets for nanophotonic applications. While observing that focused ion beam milling of crossing tapered grooves inherently produces gaps below 20 nm, we provide experimental and theoretical evidence for the spectral features of grooves terminating with a sharp air gap. We show that transmission near 10% can be obtained via two-dimensional nano-focusing in a finite subset of 2D arrays of gold nanoplatelets. This enables the application of our nanostructure to detect variations in the refractive index of thin films using either reflected or transmitted light when a small number of elements are engaged.
Diel scent and nectar rhythms of an African orchid in relation to bimodal activity patterns of hawkmoth pollinators
Authors: Balducci Marco G , Van der Niet Timotheüs , Johnson Steven D 
Published: July 2020

Abstract

Background and Aims
The temporal dimensions of floral adaptation to pollinators are not yet well understood, partly because we lack accurate information on the diel rhythms of flower visitation for many pollinators. We investigated whether diel patterns of pollinator visitation to flowers of the African woodland orchid Bonatea polypodantha are synchronized with rhythms of floral anthesis, scent emission and nectar availability.

Methods
Direct observations and motion-activated cameras were used to identify pollinators of B. polypodantha and to document their activity periods. The timing of pollinaria removal from flowers, emission of scent and availability of nectar was also measured.

Results
We found that B. polypodantha is pollinated exclusively by short-tongued hawkmoths. Pollinaria of the orchid are affixed between the labial palps of the moths and brush over the protruding stigmatic arms. The flowers also receive visits by long-tongued hawkmoths, but these act as nectar thieves. Tracking of pollinaria removal from flowers confirmed that pollination occurs only at night. Camera footage revealed a striking crepuscular pattern of foraging by short-tongued hawkmoths with peaks of activity during the twilight periods at dusk and at dawn. In contrast, long-tongued hawkmoths were found to visit flowers throughout the night. Flowers of B. polypodantha exhibit unimodal peaks of anthesis, scent emission (dominated by nitrogenous aromatics) and nectar availability before or around dusk.

Conclusions
Flowers of B. polypodantha are pollinated exclusively by short-tongued hawkmoths, which show crepuscular foraging activity at dusk and dawn. Floral phenophases of the orchid are closely synchronized with the peak of pollinator activity at dusk.
Cognitive Telerehabilitation with Transcranial Direct Current Stimulation Improves Cognitive and Emotional Functioning Following a Traumatic Brain Injury: A Case Study
Authors: Eilam-Stock Tehila , George Allan , Charvet Leigh E 
Published: July 2020

Abstract

Objective
Cognitive deficits following a traumatic brain injury (TBI) are a leading cause of disability in young adults and there is a critical need for novel approaches to improve cognitive outcomes in TBI survivors. Transcranial direct current stimulation (tDCS) paired with cognitive remediation has emerged as a viable, cost-effective, noninvasive approach for treating cognitive impairments in a wide variety of neurological conditions. Here, we report the first case study utilizing remotely supervised tDCS (RS-tDCS) protocol paired with cognitive remediation in a 29-year-old man with persisting cognitive and emotional sequelae following TBI.

Method
Neuropsychological measures were administered before and after the patient completed 20 daily sessions of RS-tDCS (2.0 mA × 20 minutes, left anodal dorsolateral prefrontal cortex montage). During the daily stimulation period, he completed adaptive cognitive training. All treatment procedures were delivered at home and monitored in real time via videoconference with a study technician.

Results
Following 20 RS-tDCS and cognitive training sessions, he had significant improvements (&gt;1 SD) on tests of attention and working memory, semantic fluency, and information processing speed. Mood was also improved.

Conclusions
This is the first demonstration of at-home telerehabilitation with RS-tDCS and cognitive training to improve cognitive outcomes following TBI.
Machine Boss: rapid prototyping of bioinformatic automata
Authors: Silvestre-Ryan Jordi , Wang Yujie , Sharma Mehak , Lin Stephen , Shen Yolanda , Dider Shihab , Holmes Ian 
Published: July 2020

Abstract

Motivation
Many software libraries for using Hidden Markov Models in bioinformatics focus on inference tasks, such as likelihood calculation, parameter-fitting and alignment. However, construction of the state machines can be a laborious task, automation of which would be time-saving and less error-prone.

Results
We present Machine Boss, a software tool implementing not just inference and parameter-fitting algorithms, but also a set of operations for manipulating and combining automata. The aim is to make prototyping of bioinformatics HMMs as quick and easy as the construction of regular expressions, with one-line ‘recipes’ for many common applications. We report data from several illustrative examples involving protein-to-DNA alignment, DNA data storage and nanopore sequence analysis.

Availability and implementation
Machine Boss is released under the BSD-3 open source license and is available from http://machineboss.org/.

Supplementary information
Supplementary data are available at Bioinformatics online.