bluuebunny/crossref_metadata_2025_split huggingface dataset:
A miniaturized tri-band bandpass microstrip filter using multiple resonators with sharp skirts
Authors: Wang Chenhao , Xi Xiaoli , Zhao Yuchen , Shi Xiaomin 
Published: September 2020

AbstractIn this paper, a miniaturized tri-band bandpass microstrip filter using stub loaded rectangular ring resonator (SLRRR)，shorted stub loaded stepped impedance resonators (SSLSIR), and stepped impedance resonators (SIR) with sharp skirts is presented. Two SSLSIRs are embedded paralleled inside SLRRR to generate a quasi-elliptic response at second and third passband. The odd-even fundamental resonant mode and first high-order resonant mode of the SIRs are exploited to generate tri-band response. Three bandwidths can be controlled independently due to different signal paths. Extra transmission zeros are introduced by the configuration of 0° feed structure. Sharp skirts are achieved at the upper edge of each passband by λg/4 lines which are loaded at the I/O ports. An example of the proposed tri-band filter operating at 2.76 GHz/5.7 GHz/7.63 GHz for TDD-LTE/WLAN/VSAT applications is implemented and fabricated. The simulation and measurement show a good agreement.
Training Machine Learning Surrogate Models From a High‐Fidelity Physics‐Based Model: Application for Real‐Time Street‐Scale Flood Prediction in an Urban Coastal Community
Authors: Zahura Faria T. , Goodall Jonathan L. , Sadler Jeffrey M. , Shen Yawen , Morsy Mohamed M. , Behl Madhur 
Published: September 2020

AbstractMitigating the adverse impacts caused by increasing flood risks in urban coastal communities requires effective flood prediction for prompt action. Typically, physics‐based 1‐D pipe/2‐D overland flow models are used to simulate urban pluvial flooding. Because these models require significant computational resources and have long run times, they are often unsuitable for real‐time flood prediction at a street scale. This study explores the potential of a machine learning method, Random Forest (RF), to serve as a surrogate model for urban flood predictions. The surrogate model was trained to relate topographic and environmental features to hourly water depths simulated by a high‐resolution 1‐D/2‐D physics‐based model at 16,914 road segments in the coastal city of Norfolk, Virginia, USA. Two training scenarios for the RF model were explored: (i) training on only the most flood‐prone street segments in the study area and (ii) training on all 16,914 street segments in the study area. The RF model yielded high predictive skill, especially for the scenario when the model was trained on only the most flood‐prone streets. The results also showed that the surrogate model reduced the computational run time of the physics‐based model by a factor of 3,000, making real‐time decision support more feasible compared to using the full physics‐based model. We concluded that machine learning surrogate models strategically trained on high‐resolution and high‐fidelity physics‐based models have the potential to significantly advance the ability to support decision making in real‐time flood management within urban communities.
Global Whole Lithosphere Isostasy: Implications for Surface Elevations, Structure, Strength, and Densities of the Continental Lithosphere
Authors: Lamb Simon , Moore James D. P. , Perez‐Gussinye Marta , Stern Tim 
Published: September 2020

AbstractThe observed variations in the thickness of the conductive lithosphere, derived from surface wave studies, have a first‐order control on the elevation of the continents, in addition to variations in the thickness of the crust—this defines whole lithosphere isostasy (WLI). Negative buoyancy of the mantle lithosphere counters the positive buoyancy of the crust, and together, their respective thicknesses and density contrasts determine elevation of the continents both in their interiors and at their edges. The average density contrasts for lithospheric mantle with crust and with asthenosphere are typically 300 to 550 and 20 to 40 kg m−3, respectively, with a ratio 10 to 16, suggesting moderate average depletion of lithospheric mantle. We show that a crustal model for Antarctica, assuming WLI and using these density contrasts, provides a close fit to estimates of crustal thickness from surface wave tomography and gravity observations. We use a global model of WLI as a framework to assess factors controlling topography, showing that plausible regional variations in crustal and mantle densities, together with uncertainties in the crustal and conductive lithospheric thicknesses, are sufficient to account for global elevations without invoking dynamic topography greater than a few hundred meters. Estimates of elastic thickness Te in the continents are typically 25–50% of the thickness of the conductive lithosphere, indicating that the mantle part supports some of the elastic strength of the lithosphere.
Enhanced Densities in the Martian Thermosphere Associated With the 2018 Planet‐Encircling Dust Event: Results From MENCA/MOM and NGIMS/MAVEN
Authors: Venkateswara Rao N. , Gupta Neha , Kadhane Umesh R. 
Published: September 2020

AbstractResponse of the Martian upper thermosphere to the lower atmospheric dust activity is studied using unique observations made together by the Mars Orbiter Mission (MOM) and the Mars Atmosphere and Volatile Evolution (MAVEN) spacecraft. The Mars Exospheric Neutral Composition Analyzer (MENCA)/MOM and the Neutral Gas and Ion Mass Spectrometer (NGIMS)/MAVEN have simultaneously (on the same day) measured the neutral densities in the Martian thermosphere on 5, 8, 10, 13, 16, and 29 June 2018. The measurement period falls in the onset and progression time of the planet‐encircling dust event (PEDE) in the Mars lower atmosphere. During this time, the inbound trajectories of MAVEN and MOM spacecraft occurred on the dawnside and duskside, respectively. Using these observations, we found that thermospheric densities both on the dawnside and duskside are enhanced associated with the onset and growth of PEDE‐2018. The enhancement, however, is more on the duskside than on the dawn, showing the dawn‐dusk asymmetry. The densities on the duskside reach their maximum on 29 June 2018, close to the time of peak dust activity. These results are explained by considering the local time asymmetries in radiative heating of the lower atmosphere and subsequent expansion of the thermosphere due to PEDE‐2018. Furthermore, O/CO2 ratios below 220‐km altitude become one on the dawnside, whereas they are always <0.2 at the dusk. This indicates that radiative cooling is more effective on the dawnside than the duskside.
A Remote Sensing Technique to Upscale Methane Emission Flux in a Subtropical Peatland
Authors: Zhang Caiyun , Comas Xavier , Brodylo David 
Published: September 2020

AbstractQuantification of methane (CH4) gas emission from peat is critical to understand CH4 budget from natural wetlands under a climate warming scenario. Previous studies have focused on prediction and mapping of CH4 emission flux using process‐based models, while application of statistical‐empirical models for upscaling spatially sparse in situ measurements is scarce. In this study, we developed an empirical remote sensing upscaling approach to estimate CH4 emission flux in the Everglades using limited in situ point‐based CH4 emission flux measurements and Landsat data during 2013–2018. We spatially and temporally linked in situ data with Landsat surface reflectance based on temporally composite data sets and developed an object‐based machine learning framework to model and map CH4 emission flux. An ensemble analysis of two machine learning models, k‐Nearest Neighbor (k‐NN) and Support Vector Machine (SVM), shows that the upscaling approach is promising for predicting CH4 emission flux with a R2 of 0.65 and 0.87 based on a fivefold cross‐validation for a dry season and wet season estimation, respectively. We generated emission flux map products that successfully revealed the spatial and temporal heterogeneity of CH4 emission within the dominant freshwater marsh ecosystem in the Everglades. We conclude that Landsat is promising for upscaling and monitoring CH4 emission flux and reducing the uncertainty in emission estimates from wetlands.
The ubiquitin ligase RNF181 stabilizes ERα and modulates breast cancer progression
Authors: Zhu Jian , Li Xin , Su Peng , Xue Min , Zang Yifeng , Ding Yinlu 
Published: September 2020

AbstractERα positive breast cancer accounts for 70% of breast malignancies. Compared with ERα negative types, ERα positive breast cancer could be effective controlled by endocrine therapy. However, more than half of the patients will develop endocrine resistance, making it an important clinical issue for breast cancer therapy. Endocrine resistance might be caused by multiple alternations, including the components of ERα signaling, during tumor progression. Thus, it is urgent and necessary to uncover the molecular mechanisms that controls ERα expression and stability to improve breast cancer therapeutics. In our current study, we identifies that the ubiquitin ligase RNF181 stabilizes ERα and facilitates breast cancer progression. The expression of RNF181 is correlated with ERα level in human breast tumors and relates to poor survival in endocrine-treated patients. RNF181 depletion inhibits breast cancer progression in vivo and in vitro, reduces ERα protein level and its target gene expression, such as PS2 and GREB1. Unbiased RNA sequencing analysis indicates RNF181 is necessary for ERα signature gene expression in whole genomic level. Immuno-precipitation assays indicate that RNF181 associates with ERα and promotes its stability possibly via inducing ERα K63-linked poly-ubiquitination. In conclusion, our data implicate a non-genomic mechanism by RNF181 via stabilizing ERα protein controls ERα target gene expression linked to breast cancer progression.
Changes in performance and bio-mathematical model performance predictions during 45 days of sleep restriction in a simulated space mission
Authors: Flynn-Evans Erin E. , Kirkley Crystal , Young Millennia , Bathurst Nicholas , Gregory Kevin , Vogelpohl Verena , End Albert , Hillenius Steven , Pecena Yvonne , Marquez Jessica J. 
Published: September 2020

AbstractLunar habitation and exploration of space beyond low-Earth orbit will require small crews to live in isolation and confinement while maintaining a high level of performance with limited support from mission control. Astronauts only achieve approximately 6 h of sleep per night, but few studies have linked sleep deficiency in space to performance impairment. We studied crewmembers over 45 days during a simulated space mission that included 5 h of sleep opportunity on weekdays and 8 h of sleep on weekends to characterize changes in performance on the psychomotor vigilance task (PVT) and subjective fatigue ratings. We further evaluated how well bio-mathematical models designed to predict performance changes due to sleep loss compared to objective performance. We studied 20 individuals during five missions and found that objective performance, but not subjective fatigue, declined from the beginning to the end of the mission. We found that bio-mathematical models were able to predict average changes across the mission but were less sensitive at predicting individual-level performance. Our findings suggest that sleep should be prioritized in lunar crews to minimize the potential for performance errors. Bio-mathematical models may be useful for aiding crews in schedule design but not for individual-level fitness-for-duty decisions.
Implementation of a red blood cell-optical (RBO) channel for detection of latent iron deficiency anaemia by automated measurement of autofluorescence-emitting red blood cells
Authors: Tougan Takahiro , Itagaki Sawako , Toya Yuji , Uchihashi Kinya , Horii Toshihiro 
Published: September 2020

AbstractIron deficiency is the most common and widespread nutritional disorder worldwide. The automated haematology analyser XN-30 (Sysmex, Kobe, Japan) was developed to detect malaria-infected red blood cells (RBCs) in human blood samples using flow cytometry. The optical system of the analyser detects autofluorescence (AF)-emitting RBCs containing iron-deficient haem groups and would aid in the diagnosis of anaemia resulting from iron deficiency. Here, an RBC-optical (RBO) channel was devised and implemented on the analyser. In vitro analyses showed that the analyser detected AF-emitting RBCs treated with 5-aminolevulinic acid. Furthermore, the analyser detected AF-emitting RBCs in mice fed a low iron diet and infected with a rodent malaria parasite; it could also be effectively used in humans. This study demonstrates that the analyser can quantitatively and reproducibly detect AF-emitting RBCs and measure other haematological parameters, suggesting its usefulness for the initial evaluation of latent iron deficiency anaemia in conjunction with the diagnosis of malaria.
A first evaluation of the usefulness of Kudzu starch in cultural heritage restoration
Authors: Lama E. , Veneranda M. , Prieto-Taboada N. , Hernando F. L. , Rodríguez Laso M. D. , Madariaga J. M. 
Published: September 2020

AbstractIn recent times, the use of natural and harmless products for the environment and restorer is taking place in the field of Cultural Heritage restoration. In this sense, wheat, rice and corn starches as adhesives, have suitable characteristics without toxicity risks. A new starch in this field, is the Kudzu, an almost pure compound (99.5% starch) that is processed by a natural way from a plant called Pueraria lobata. This is a preliminary study of the potential use of Kudzu starch for the restoration of Cultural Heritage, focusing, firstly, in its capacity as adhesive through a comparative evaluation with common starches. The accelerated aging process carried out proved that Kudzu ensures optimal chromatic behaviour. On the other hand, the main problem in starch paste is the biological colonization. The daidzein, a natural antimicrobial compound implicit in Kudzu starch, confirmed the resistance to microorganism in this preliminary approach. The evaluation of the adhesive capacity, and the reversibility of the starches, suggest that Kudzu starch is a valid adhesive in the field of paper restoration. Thus, the potential of this starch in the conservation of Cultural Heritage is evidenced and its use as cleaner, resistance to biological colonization and consolidant is promising.
Inducible EphA4 knockout causes motor deficits in young mice and is not protective in the SOD1G93A mouse model of ALS
Authors: Dominguez Sara L. , Earr Timothy , Dourado Michelle , Ngu Hai , Meilandt William J. , Hanson Jesse E. 
Published: September 2020

AbstractAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron loss that ultimately leads to fatal paralysis. Reducing levels or function of the tyrosine kinase, ephrin type-A receptor 4 (EphA4), has been suggested as a potential approach for slowing disease progression in ALS. Because EphA4 plays roles in embryonic nervous system development, study of constitutive knockout (KO) of EphA4 in mice is limited due to confounding phenotypes with homozygous knockout. We used a tamoxifen-inducible EphA4 conditional KO mouse to achieve strong reduction of EphA4 levels in postnatal mice to test for protective effects in the SOD1G93A model of ALS. We found that EphA4 KO in young mice, but not older adult mice, causes defects in muscle function, consistent with a prolonged postnatal role for EphA4 in adolescent muscle growth. When testing the effects of inducible EphA4 KO at different timepoints in SOD1G93A mice, we found no benefits on motor function or disease pathology, including muscle denervation and motor neuron loss. Our results demonstrate deleterious effects of reducing EphA4 levels in juvenile mice and do not provide support for the hypothesis that widespread EphA4 reduction is beneficial in the SOD1G93A mouse model of ALS.
Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage
Authors: Houseright Ruth A. , Rosowski Emily E. , Lam Pui-Ying , Tauzin Sebastien J. M. , Mulvaney Oscar , Dewey Colin N. , Huttenlocher Anna 
Published: September 2020

AbstractTissue damage induces rapid recruitment of leukocytes and changes in the transcriptional landscape that influence wound healing. However, the cell-type specific transcriptional changes that influence leukocyte function and tissue repair have not been well characterized. Here, we employed translating ribosome affinity purification (TRAP) and RNA sequencing, TRAP-seq, in larval zebrafish to identify genes differentially expressed in neutrophils, macrophages, and epithelial cells in response to wounding. We identified the complement pathway andc3a.1, homologous to the C3 component of human complement, as significantly increased in neutrophils in response to wounds.c3a.1−/−zebrafish larvae have impaired neutrophil directed migration to tail wounds with an initial lag in recruitment early after wounding. Moreover,c3a.1−/−zebrafish larvae have impaired recruitment to localized bacterial infections and reduced survival that is, at least in part, neutrophil mediated. Together, our findings support the power of TRAP-seq to identify cell type specific changes in gene expression that influence neutrophil behavior in response to tissue damage.
The comparison of nailfold videocapillaroscopy findings between anti-melanoma differentiation-associated gene 5 antibody and anti-aminoacyl tRNA synthetase antibody in patients with dermatomyositis complicated by interstitial lung disease
Authors: Wakura Reiko , Matsuda Shogo , Kotani Takuya , Shoda Takeshi , Takeuchi Tohru 
Published: September 2020

AbstractDermatomyositis (DM) is frequently complicated by interstitial lung disease (ILD), which increases mortality. This study aims to elucidate the clinical significance of nailfold videocapillaroscopy (NVC) on assessing the disease activity and prognosis of DM-ILD. We compared the NVC findings between anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody-positive and anti-aminoacyl tRNA synthetase (anti-ARS) antibody-positive patients, the survival and ILD-related death groups, and examined the association of NVC findings with prognostic factors of DM-ILD. The median scores of microhemorrhage and capillary disorganization in the anti-MDA5 antibody-positive group were significantly higher than those in the anti-ARS antibody-positive group (P = 0.012 and 0.044, respectively). In contrast, the median scores of tortuous capillaries in the anti-ARS antibody-positive group were significantly higher than those in the anti-MDA5 antibody-positive group (P = 0.002). The median scores of microhemorrhage was significantly higher in the ILD-related death group than the survival group (P = 0.02). The scores of microhemorrhage, capillary disorganization, and neoangiogenesis correlated with known poor prognosis factors of DM-ILD. Additionally, the scores of microhemorrhage and capillary loss correlated significantly with the total fibrosis scores of chest high-resolution computed tomography. These findings suggest that NVC is a useful tool for assessing the disease activity and prognosis of DM-ILD.
A prospective study of lung disease in a cohort of early rheumatoid arthritis patients
Authors: Robles-Pérez A. , Luburich P. , Bolivar S. , Dorca J. , Nolla J. M. , Molina-Molina M. , Narváez J. 
Published: September 2020

AbstractLung disease is common in patients with rheumatoid arthritis (RA). The onset of lung involvement in RA is not well known. The objective is to describe the features and evolution of lung involvement in early RA, its relationship with disease activity parameters, smoking and treatments. Consecutive patients with early RA without respiratory symptoms were included and tracked for 5 years. Lung assessment included clinical, radiological and pulmonary function tests at diagnosis and during follow-up. Peripheral blood parameters (erythrocyte sedimentation rate, C reactive protein, rheumatoid factor and anti-citrullinated peptide autoantibodies) and scales of articular involvement, such as DAS28-CRP, were evaluated. 40 patients were included and 32 completed the 5-year follow up. 13 patients presented lung involvement in the initial 5 years after RA diagnosis, 3 of them interstitial lung disease. Significant decrease of diffusion lung transfer capacity of carbon monoxide over time was observed in six patients, 2 of them developed interstitial lung disease. DLCO decrease was correlated with higher values of CRP and ESR at diagnosis. Methotrexate was not associated with DLCO deterioration or lung disease development. Subclinical progressive lung disease correlates with RA activity parameters. Smoking status and methotrexate were not associated with development or progression of lung disease.
Naphthoquinone-derivative as a synthetic compound to overcome the antibiotic resistance of methicillin-resistant S. aureus
Authors: Song Ronghui , Yu Bing , Friedrich Dirk , Li Junfeng , Shen Hao , Krautscheid Harald , Huang Songping D. , Kim Min-Ho 
Published: September 2020

AbstractThe treatment of Staphylococcus aureus (S. aureus) infections has become more difficult due to the emergence of multidrug resistance in the bacteria. Here, we report the synthesis of a lawsone (2-hydroxy-1,4-naphthoquinone)-based compound as an antimicrobial agent against methicillin-resistant S. aureus (MRSA). A series of lawsone-derivative compounds were synthesized by means of tuning the lipophilicity of lawsone and screened for minimum inhibitory concentrations against MRSA to identify a candidate compound that possesses a potent antibacterial activity. The identified lawsone-derivative compound exhibited significantly improved drug resistance profiles against MRSA compared to conventional antibiotics. The therapeutic efficacy of the compound was validated using murine models of wound infection as well as non-lethal systemic infection induced by MRSA. Our study further revealed the multifaceted modes of action of the compound, mediated by three distinctive mechanisms: (1) cell membrane damage, (2) chelation of intracellular iron ions, and (3) generation of intracellular reactive oxygen species.
Rupture of the Globe: What to Do, What not to Do
Authors: Joussen Antonia M. , Müller Bert , Kirchhof Bernd , Stappler Theodor , Zeitz Oliver 
Published: September 2020

AbstractDue to their complexity, globe ruptures are highly compromising traumas for the patient. This is due on the one hand to the eye injury itself with the accompanying loss of vision and on the other hand due to the need for extended treatment with uncertain prognosis and the resulting psychological stress. Globe ruptures are among the prognostically most unfavorable injuries due to the force and peak pressure impacting the eye. Furthermore, contusional retinal necrosis may be of significance prognostically. In the present review, we discuss treatment of globe ruptures involving retinal surgery. We discuss the primary sugery, its chronological planning and extent as well as the necessity for follow-up interventions. We also discuss the origin of traumatic retinal detachment with differential diagnosis of giant retinal tear versus oradialysis as well as secondary sequelae of traumas such as formation of macular holes and their treatment. On this basis, the use of buckling surgery versus pars-plana vitrectomy is discussed. Further focus is set on the role of the iris lens diaphragm in surgery of globe ruptures.