bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estudio de verificación de precisión y veracidad en un sistema Atellica
Authors: Vílchez Rodríguez Alberto , González Cantó Julia , Esteve Poblador Sara , Valldecabres Ortiz Carmen , Estela Burriel Pedro L. 
Published: September 2020

Resumen

Objetivos
El laboratorio clínico debe usar solamente procedimientos de medida validados. La precisión es una de las características más importantes para seleccionar, incorporar, validar y verificar un procedimiento de medida. El objetivo fue verificar la precisión y veracidad de varias magnitudes en distintos analizadores de bioquímica e inmunoquímica.

Materiales
Los analizadores en uso fueron Advia 1800®, Immulite®2000 y CentaurXP®, y el sistema evaluado fue Atellica®Solution. Se evaluaron cinco magnitudes para bioquímica y cinco para inmunoquímica. Para estudiar la imprecisión se utilizaron materiales de control comercial de BioRad® y Siemens®, calculando la imprecisión intraserial e interserial analizando tres replicados de cada control en una única serie cada día, durante 5 días. Para el estudio de veracidad se analizaron 40 muestras de suero diferentes mediante el análisis de diferencias y regresión lineal.

Resultados
Los valores obtenidos para la imprecisión intraserial e interserial fueron menores a los proporcionados por el fabricante en todas las magnitudes estudiadas. En el estudio de veracidad, existe error sistemático proporcional pero no constante para algunas magnitudes.

Conclusiones
Según los coeficientes de variación (CV%) obtenidos en el Atellica®Solution se verificaron las especificaciones de imprecisión proporcionadas por el fabricante y las establecidas por el laboratorio. Respecto al estudio de veracidad sería necesario para algunos parámetros, revisar las condiciones de calibración y ampliar el rango de muestras estudiado.
A Hybrid Equity Release Plan for Retirement Financing
Authors: Kwong Koon-Shing , Tse Yiu-Kuen , Chay Junxing 
Published: September 2020

Abstract
There are two main equity release plans for retirement financing: reverse mortgage plan and home reversion plan. Both plans entitle the homeowners not only to release cash from their properties but also to allow them living there for life. In the lease buyback scheme (LBS) recently introduced in Singapore, the home owner sells the tail-end of the property lease to the government in exchange for a cash payment upfront. Unlike the two main equity release plans, the LBS only allows the owner to stay in the property for the front part of the lease but not for life.
In this paper, we propose a hybrid home equity release plan that incorporates features of the home reversion plan and the LBS. We provide an actuarial framework to analyze the pricing of the hybrid plan, as well as the LBS and home reversion plan. Some numerical illustrations are presented to show the actuarial values of the plan under different choices of plan parameters, such as the lease period and the portion of property value sold. The hybrid plan provides enhanced flexibility to plan takers to meet their retirement needs.
Economic power control for offshore wind farms with loop connection cables
Authors: Scholz Janine , Wiebe Eduard , Scheffer Volker , Becker Christian 
Published: September 2020

Abstract
The Canadian developer and owner of green power facilities Northland Power Inc. owns two offshore wind farms (OWFs) in the German Bight, Deutsche Bucht and Nordsee One, operated by the subsidiary Northland Power Europe GmbH. The company supports and conducts research in the field of power flow optimization in wind farm networks. The work at hand represents the results of this effort to maximize the efficiency of the assets. The project was accomplished within a cooperation between the Nordsee One GmbH and the Institute of Electrical Power and Energy Technology at the Hamburg University of Technology.
From an external point of view, an OWF represents an “en bloc” power plant connected to the onshore transmission grid via power export cables. Nevertheless, such a power plant comprises a complex, large-scale internal medium voltage network. In case of failure or cable outage, the network topology of an OWF may be modified and unintended overloading of inter-array cables (IACs) is possible. In order to address this issue, a new algorithm and software tool for economic power control in OWFs are introduced in the following which can be employed in wind farms with integrated loop connection cables (LCCs). This configuration particularly entails the risk of overloading cable segments depending on the present wind speed. The new algorithm provides the operator with adapted active power setpoints for each wind turbine generator (WTG) in a given network topology. The aim is to maximize OWF power generation and minimize internal power losses while secure network operation is guaranteed. Using load flow analysis based on WTG power output measurements, the load on each cable section is monitored and the cables can be utilized to their individual full capacity while overload is avoided. The practicability of the approach is demonstrated by means of simulation results.
Durchgängiges Anforderungsmanagement und Engineering für Smart Grid Lösungen
Authors: Uslar Mathias 
Published: September 2020

Zusammenfassung
In diesem Beitrag wird die Notwendigkeit einer sinnvollen Definition und Klarstellung der Disziplin Energieinformatik aufgezeigt. Der Beitrag diskutiert verschiedene bestehende Definitionen und stellt sie in den Kontext des Anforderungsmanagements und der Lösungsfindung. Er motiviert die Notwendigkeit eines strukturierten disziplinären Ansatzes in der Energieinformatik auf der Grundlage bestehender Probleme und skizziert den aktuellen Stand des Stands der Wissenschaft und Technik, der hauptsächlich den systemtechnischen Anwendungsbereich für Smart Grids umfasst. Synergien mit anderen aktuellen Schwerpunktthemen wie Internet der Dinge (IoT), Industrie 4.0 (Digitalisierung der Produktion) und Cyber-Physical Systems (CPS) werden aus Anforderungssicht motiviert. Auf der Grundlage der aufgeworfenen Fragen und Herausforderungen werden neue sinnvolle Forschungsthemen für ein durchgängiges Anforderungsmanagement im Kontext Smart Grid diskutiert.
Neue Methodik zur Optimierung von Druckverfahren für die Herstellung funktionaler Mikrostrukturen und hybrider elektronischer Schaltungen
Authors: Ungerer Martin 
Published: September 2020

Zusammenfassung
Für eine wirtschaftliche Anwendbarkeit der gedruckten Elektronik sind die Zuverlässigkeit von Prozessen und die Reproduzierbarkeit der Druckerzeugnisse von zentraler Bedeutung. Anhand der in dieser Dissertation entwickelten methodischen Vorgehensweise zur ganzheitlichen Optimierung digitaler Druckprozesse werden ein neues Extrusionsdrucksystem für hoch- und ein piezoelektrisches Inkjet-Drucksystem für niedrigviskose funktionale Tinten aufgebaut und experimentell für verschiedene Tinten und Substrate in Parameterstudien sowie anhand komplexer Anwendungsbeispiele evaluiert. Die Optimierung des Ultraschall-Plottverfahrens sowie die zum Patent angemeldete Neuentwicklung des Aerosol on Demand Jet-Druckverfahrens sind neben dem Vergleich verschiedener digitaler Einkanal-Drucksysteme und dem Nachweis der Funktionsfähigkeit der entwickelten Methodik weitere zentrale Punkte der Arbeit.
MiR-4328 inhibits proliferation, metastasis and induces apoptosis in keloid fibroblasts by targeting BCL2 expression
Authors: Tang Hongmei , Chen Qi , Yu Wenyuan , Zhao Tianlan 
Published: September 2020

AbstractKeloids are considered to be a type of benign tumor. MicroRNAs have been reported to be involved in the formation and growth of keloids. MicroRNA-4328 (miR-4328) was found to be abnormally expressed in keloids, while the role and the detailed molecular mechanism of miR-4328 in keloids remain unclear. The expression of miR-4328 and B-cell lymphoma 2 (BCL2) mRNA was detected by qRT-PCR. The proliferation, migration, invasion and apoptosis of keloid fibroblasts (KFs) was examined using Cell Counting Kit-8 assay, transwell assay or flow cytometry, respectively. Western blot was used to detect the level of proliferating cell nuclear antigen, cleaved-caspase 3, collagen I, collagen III and BCL2 protein. The interaction between miR-4328 and BCL2 was confirmed by luciferase reporter analyses. It was observed that miR-4328 was down-regulated in keloid tissues and fibroblasts, and miR-4328 restoration mediated the inhibition of proliferation, metastasis, collagen synthesis and the promotion of apoptosis in KFs. BCL2 was up-regulated in keloid tissues and fibroblasts, and BCL2 knockdown promoted the deterioration of KFs. In addition, BCL2 was confirmed to be a target of miR-4328, and the rescue experiment indicated that the inhibitory action of miR-4328 on keloid fibroblast progression was reversed by BCL2 overexpression. Thus, our results demonstrated that miR-4328 restrained the deterioration of KFs by targeting BCL2, which sheds new light on miR-4328 as a promising target for keloid development and therapeutic.
Aberrant expression of microRNA-132-3p and microRNA-146a-5p in Parkinson’s disease patients
Authors: Shu Yu , Qian Jinjun , Wang Chunyan 
Published: September 2020

AbstractParkinson’s disease (PD) is an age-related neurodegenerative disorder which is assessed based on the motor symptoms. A number of microRNAs (miRNAs) are dysregulated and involved in the pathogenesis or development of PD. However, no confirmed markers are used for the early detection of PD. The present study aimed to elucidate the potential two miRNAs (miR-132-3p and miR-146-5p) as novel markers for early PD diagnosis. In the present study, the expression levels of miR-132-3p and miR-146-5p in serum samples from 82 patients with PD and 44 healthy volunteers were measured by reverse transcription-quantitative polymerase chain reaction. Furthermore, the correlation analysis was performed between aberrant miRNAs and Braak staging, Part V of the Unified Parkinson’s Disease Rating Scale (UPDRS-V; the modified Hoehn and Yahr staging of PD) and Part III of the UPDRS-III. Subsequently, the receiver–operating characteristic (ROC) curve results of miR-132-3p and miR-146-5p from healthy volunteers for PD prediction and from severe PD patients were assessed. From the results it was observed that miR-132-3p and miR-146a-5p expressions were significantly decreased in the serum samples of patients with PD compared to those in the healthy volunteers. Moreover, the expressions of miR-132-3p and miR-146a-5p showed a dramatic decrease in severe PD patients as compared to the normal PD patients. Meanwhile, miR-132-3p and miR-146-5p expressions were negatively correlated with Braak staging (r = −0.45, P < 0.0001; r = −0.51, P < 0.0001), UPDRS-III (r = −0.55, P < 0.0001; r = −0.51, P < 0.0001) and UPDRS-V scores (r = − 0.46, P < 0.0001; r = −0.45, P < 0.0001) in PD patients. The area under the curve (AUC) results of miR-132-3p and miR-146a-5p in discriminating PD patients from the healthy controls were 0.7325 (95% CI = 0.6400–0.8251) and 0.7295 (95% CI = 0.3658–0.8232). Moreover, the AUC results of miR-132-3p and miR-146-5p concerning discriminating severe PD patients from normal PD patients were 0.8175 (95% CI = 0.7229–0.9121) and 0.7921 (95% CI = 0.6937–0.8905). In other words, both miR-132-3p and miR-146a-5p may function as promising biomarkers for early diagnosis of PD.
Biosurfactant production by a Bacillus megaterium strain
Authors: Stancu Mihaela Marilena 
Published: September 2020

AbstractThe aim of the present study was to investigate the ability of Bacillus megaterium IBBPo17 (GenBank KX499518) cells to produce biosurfactant when the growth was done in the presence of long-chain n-alkane n-hexadecane on medium supplemented with yeast extract, proteose peptone, starch, or cellulose. B. megaterium IBBPo17 revealed a higher growth in the presence of n-hexadecane when the medium was supplemented with yeast extract, proteose peptone, or starch, compared with cellulose. Biosurfactant production was higher when B. megaterium IBBPo17 was grown in the presence of n-hexadecane on yeast extract, proteose peptone, or starch supplemented medium, compared with biosurfactant produced on cellulose supplemented medium. A direct correlation between cell growth and biosurfactant production was observed. When the growth of B. megaterium IBBPo17 cells was higher, the decrease in pH values of the medium was higher too, and more amount of CO2 was released. Changes in cell morphology, aggregation of the cells in clusters, and biofilm formation were observed when B. megaterium IBBPo17 was grown in the presence of n-hexadecane on medium supplemented with yeast extract, proteose peptone, starch, or cellulose. Due to its physiological abilities, this Gram-positive bacterium could be a promising candidate for the bioremediation of petroleum hydrocarbon polluted environments.
The Ulvophyceae (Chlorophyta) of eastern Sorsogon, Philippines, including Halimeda magnicuneata sp. nov. (Bryopsidales)
Authors: Dumilag Richard V. , Dumago Ferdinand S. , Cabudoy Rea Kissel R. , Peralta Mark Christian E. , Li Camille C. , Gamus Glenn Cedrick V. , Romero Rose Glendelyn T. , Yap Sandra L. , Roleda Michael Y. , Geraldino Paul John L. , Verbruggen Heroen , Leliaert Frederik , Draisma Stefano G.A. , Liao Lawrence M. , Kraft Gerald T. 
Published: September 2020

Abstract
The marine algal flora of eastern Sorsogon has been intensively collected and is generally considered as the richest in the Philippines. A trend of species records in the area has been dominated by rhodophytes (red algae) with significantly fewer similar studies for other algal groups (green and brown algae). In this study we present an updated catalogue of the green seaweeds (Ulvophyceae) of eastern Sorsogon. A checklist, including notes on taxonomy, is given of the 103 species. Twenty-six species are newly recorded locally of which five represent new records for the Philippines: Avrainvillea amadelpha, Caulerpa buginensis, an unidentified Caulerpa species, Codium cf. latum, and one taxon new to science. The new species is described as Halimeda magnicuneata Verbruggen et Dumilag based on morpho-anatomy and DNA sequence data. The number of ulvophycean species recorded in eastern Sorsogon is found to be the highest in the Philippines. This may be a result of the high collection effort in the region, as well as eastern Sorsogon’s diverse habitats providing favourable conditions for a wide range of seaweed species.
Trimethylamine-N-oxide (TMAO) predicts short- and long-term mortality and poor neurological outcome in out-of-hospital cardiac arrest patients
Authors: Hochstrasser Seraina R. , Metzger Kerstin , Vincent Alessia M. , Becker Christoph , Keller Annalena K. J. , Beck Katharina , Perrig Sebastian , Tisljar Kai , Sutter Raoul , Schuetz Philipp , Bernasconi Luca , Neyer Peter , Marsch Stephan , Hunziker Sabina 
Published: September 2020

Abstract

Objectives
Prior research found the gut microbiota-dependent and pro-atherogenic molecule trimethylamine-N-oxide (TMAO) to be associated with cardiovascular events as well as all-cause mortality in different patient populations with cardiovascular disease. Our aim was to investigate the prognostic value of TMAO regarding clinical outcomes in patients after out-of-hospital cardiac arrest (OHCA).

Methods
We included consecutive OHCA patients upon intensive care unit admission into this prospective observational study between October 2012 and May 2016. We studied associations of admission serum TMAO with in-hospital mortality (primary endpoint), 90-day mortality and neurological outcome defined by the Cerebral Performance Category (CPC) scale.

Results
We included 258 OHCA patients of which 44.6% died during hospitalization. Hospital non-survivors showed significantly higher admission TMAO levels (μmol L−1) compared to hospital survivors (median interquartile range (IQR) 13.2 (6.6–34.9) vs. 6.4 (2.9–15.9), p<0.001). After multivariate adjustment for other prognostic factors, TMAO levels were significantly associated with in-hospital mortality (adjusted odds ratios (OR) 2.1, 95%CI 1.1–4.2, p=0.026). Results for secondary outcomes were similar with significant associations with 90-day mortality and neurological outcome in univariate analyses.

Conclusions
In patients after OHCA, TMAO levels were independently associated with in-hospital mortality and other adverse clinical outcomes and may help to improve prognostication for these patients in the future. Whether TMAO levels can be influenced by nutritional interventions should be addressed in future studies.
The spatial and temporal distribution of cationic and anionic radicals in early embryo implantation
Authors: Bai Zhikun 
Published: September 2020

AbstractThe main objective of this study is to obtain some knowledge of cationic and anionic radicals in early embryo implantation in mice. The method used in this study is known as histochemical staining, in which Xylidine ponceau was used at pH 2.5 and toluidine blue was used at pH 4.0. We detected the change in glycosaminoglycans and total proteins in the endometrial stroma during the preimplantation of mice. This study revealed that the distribution patterns of cationic radicals and anionic radicals are similar on days 4 and 5 of pregnancy. However, there was a distinct difference between cationic radicals and anionic radicals on day 8 of pregnancy. The distribution pattern of cationic radicals is more concentrated in the stroma near the conceptus. Laboratory studies on histochemical stain provide more information about early embryo implantation.
Multivariate analysis for the classification of copper–lead and copper–zinc glasses
Authors: Dimitrov Dimitar , Nedyalkova Miroslava , Madurga Sergio , Naneva Ludmila , Simeonov Vasil 
Published: September 2020

AbstractThe similarity patterns in the physicochemical properties of copper–lead and copper–zinc borate glasses were identified by means of finding similarity within the objects of study using multivariate statistical analysis. As exploratory methods of multivariate analysis, cluster analysis, principal components analysis, and two-way clustering were applied for a set of copper–lead and copper–zinc borate glasses. Specific correlations among the physicochemical properties of copper glasses were interpreted. In particular, the effect of Pb and Zn doping metal ion in copper glasses in the structural and mechanical properties is identified. Interestingly, the degree of lead content determines two kinds of glasses with specific physicochemical properties.
Fluorescence in the assessment of the share of a key component in the mixing of feed
Authors: Matuszek Dominika Barbara 
Published: September 2020

AbstractThis paper presents the results of the mixing of a multicomponent feed for cattle. Three types of mixtures with different proportions of individual components and granulometric composition were selected. After the mixing process, the fraction of the key component (tracer) was determined. Tracer consisted of crushed grains of yellow maize, which was wet treated with a 0.01% solution of Rhodamine B. A tracer with two different average particle sizes d1 = 2.0 mm and d2 = 1.25 mm was introduced into the mixture. Then, the sample was illuminated with UV light, and the content of the tracer in the sample was evaluated using the computer image analysis. In addition, the tracer was separated to determine its fraction using a laboratory scale. From the obtained results, the high reliability of the fluorescence optical method for the evaluation of the homogeneity of granular multicomponent mixtures was proved. It was also observed that slightly better results were obtained for a tracer with a larger average particle size (d = 2.0 mm), although the comparative analysis did not indicate a significant statistical difference in the results in each series of tests.
Local Discontinuous Galerkin Method for Time-Dependent Singularly Perturbed Semilinear Reaction-Diffusion Problems
Authors: Cheng Yao , Song Chuanjing , Mei Yanjie 
Published: September 2020

Abstract
Local discontinuous Galerkin method is considered
for time-dependent singularly perturbed semilinear problems with boundary layer.
The method is equipped with a general numerical flux
including two kinds of independent parameters.
By virtue of the weighted estimates and suitably designed global projections,
we establish optimal

(

k
+
1

)

{(k+1)}

-th error estimate in a local region
at a distance of

𝒪
⁢

(

h
⁢

log
⁡

(

1
h

)

)

{\mathcal{O}(h\log(\frac{1}{h}))}

from domain boundary.
Here k is the degree of piecewise polynomials in the discontinuous finite element space
and h is the maximum mesh size.
Both semi-discrete LDG method
and fully discrete LDG method with a third-order explicit Runge–Kutta
time-marching are considered.
Numerical experiments support our theoretical results.
Exploring the interplay of language and body in South African youth: A portrait-corpus study
Authors: Peters Arne , Coetzee-Van Rooy Susan 
Published: September 2020

AbstractElicitation materials like language portraits are useful to investigate people’s perceptions about the languages that they know. This study uses portraits to analyse the underlying conceptualisations people exhibit when reflecting on their language repertoires. Conceptualisations as manifestations of cultural cognition are the purview of cognitive sociolinguistics. The present study advances portrait methodology as it analyses data from structured language portraits of 105 South African youth as a linguistic corpus from both qualitative and quantitative perspectives. The approach enables the uncovering of (a) prominent underlying conceptualisations of African language(s) and the body, and (b) the differences and similarities of these conceptualisations vis-à-vis previous cognitive (socio)linguistic studies of embodied language experiences. In our analysis, African home languages emerged both as ‘languages of the heart’ linked to cultural identity and as ‘languages of the head’ linked to cognitive strength and control. Moreover, the notion of ‘degrees of proficiency’ or ‘magnitude’ of language knowledge emerged more prominently than in previous studies of embodied language experience.