bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using VRE screening tests to predict vancomycin resistance in enterococcal bacteremia
Authors: Butler-Laporte Guillaume , Cheng Matthew P. , McDonald Emily G. , Lee Todd C. 
Published: January 2020

AbstractBackground and objective:Enterococcuscauses clinically significant bloodstream infections (BSIs). In centers with a higher prevalence of vancomycin resistant enterococcus (VRE) colonization, a common clinical question is whether empiric treatment directed against VRE should be initiated in the setting of a suspected enterococcal BSI. Unfortunately, VRE treatment options are limited, and relatively expensive, and subject patients to the risk of adverse reactions. We hypothesized that the results of VRE colonization screening could predict vancomycin resistance in enterococcal BSI.Methods:We reviewed 370 consecutive cases of enterococcal BSI over a 7-year period at 2 tertiary-care hospitals to determine whether vancomycin-resistant BSIs could be predicted based on known colonization status (ie, patients with swabs performed within 30 days, more remotely, or never tested). We calculated sensitivity and specificity, and we plotted negative predictives values (NPVs) and positive predictive values (PPVs) as a function of prevalence.Results:A negative screening swab within 30 days of infection yielded NPVs of 90% and 95% in settings where <27.0% and 15.0% of enterococcal BSI are resistant to vancomycin, respectively. In patients with known VRE colonization, the PPV for VRE in enterococcal BSI was >50% at any prevalence exceeding 25%.Conclusions:The results of a negative VRE screening test result performed within 30 days can help eliminate unnecessary empiric therapy in patients with suspected enterococcal BSI. Conversely, patients with positive VRE screening swabs require careful consideration of empiric VRE-directed therapy when enterococcal BSI appears likely.
The validity of validation: A practical assessment
Authors: Stone Eric C. , Miller Vickie , Shedenhelm Heidi J. , Hellinger Walter C. , O’Horo John C. 
Published: January 2020

AbstractObjective:To assess the time to achieve reliable reporting of electronic health record data compared with manual reporting during validation.Design:Secondary analysis of aggregate data for number of patients present, number of patients with a central venous catheter, and number of patients with an indwelling urinary catheter during validation of an electronic health record reporting tool.Setting:Mayo Clinic Health System in Wisconsin.Participants:Mayo Clinic infection prevention and control staff, unit champions, and all inpatients.Methods:We simultaneously collected electronic and manual counts of device data and compared discrepancies to determine their source. If manual data entry was incorrect, manual counts were coded as inaccurate. If electronically abstracted data did not reflect an accurate count, errors were attributed to the system. Data were compared using standard statistical methods.Results:Within 30 days after beginning validation of electronic reporting for central venous catheter days and urinary catheter days, electronic counts were durably more reliable than manual counts.Conclusions:Manual validation for capturing and reporting electronic data and reporting can be shorter than the 90 days currently mandated by National Healthcare Safety Network criteria. Compared with a longer validation period, a shorter validation period may yield substantial savings while achieving the same validity.
Potential for the current National Healthcare Safety Network (NHSN) >3 days after admission definition of laboratory-identified, healthcare-facility–onset, Clostridioides difficile infection (HO-CDI) to overestimate rates
Authors: Puri Shruti , Hughes Heather Y. , McCrackin Monica D. , Williford Robert , Gebregziabher Mulugeta , Salgado Cassandra D. , Curry Scott R. 
Published: January 2020

AbstractHealthcare-facility–onset C.difficile LabID events are defined as positive stool samples collected >3 days after hospitalization. Using a definition of >72 hours, we found that 84 of 1013 cases (8.3%) identified as C. difficile LabID events were collected between 48 and 72 hours after admission.
Rethinking the association between overweight/obesity and ADHD in children: a longitudinal and psychosocial perspective
Authors: Donnchadha S. Ó. , Bramham J. , Greene C. 
Published: January 2020

Objective:This study examines the association between attention-deficit/hyperactivity disorder (ADHD) and overweight/obesity in a large-scale longitudinal study of children, while controlling for a range of psychosocial factors.Method:Data were obtained from Growing Up in Ireland, a nationally representative and longitudinal study of approximately 6500 children who were assessed at 9 and 13 years of age. Body mass index (BMI) was determined using measured height and weight, ADHD status was determined by parent reports of professional diagnoses and ADHD symptoms were measured using the Strengths and Difficulties Questionnaire (SDQ).Results:The associations between ADHD status, ADHD symptoms (SDQ) and BMI category at age 9 and 13 years were evaluated using logistic regression. Adjustments were made for child factors (sex, developmental coordination disorder, emotional symptoms, conduct problems, birth weight and exercise) and parental factors (socio-economic status, parental BMI, parental depression, and maternal smoking and alcohol use during pregnancy). Logistic regression indicated that ADHD status was not associated with BMI category at 9 or at 13 years of age, but children with ADHD at 9 years were significantly more likely to be overweight/obese at 13 years than those without ADHD. However, when other child and parental factors were adjusted for, ADHD status was no longer significantly associated with weight status. Female sex, low levels of exercise, overweight/obese parents and prenatal smoking during pregnancy consistently increased the odds of childhood overweight/obesity.Conclusions:While ADHD and overweight/obesity co-occur in general populations, this relationship is largely explained by a variety of psychosocial factors.
Women’s Activism in the Civil Resistance Movement in Kosovo (1989–1997): Characteristics, Development, Encounters
Authors: Mujika Chao Itziar 
Published: January 2020

AbstractThis article analyzes women’s socio-political participation and activism within the nonviolent civil resistance movement in prewar Kosovo between 1989 and 1997, as well as the movement’s gender dynamics. This Albanian-led resistance movement emerged during the early 1990s with the principal goal of building a parallel state, seeking independence from Serbia, and offering means of survival for the population. This project required the participation of all Albanian citizens, and although the participation of women was massive, this has gone largely unrecognized. This article will explore the principal features of women’s participation and activism within this movement, what kind of gendered dynamics were developed, and the principal forms of resistance they encountered against their full and active participation through an analysis of women’s activism both within the Women’s Forum of the Democratic League of Kosovo and within independent women’s organizations.
Least energy solution for a scalar field equation with a singular nonlinearity
Authors: Byeon Jaeyoung , Choi Sun-Ho , Kim Yeonho , Moon Sang-Hyuck 
Published: January 2020

AbstractWe are concerned with a nonnegative solution to the scalar field equation
$$\Delta u + f(u) = 0{\rm in }{\open R}^N,\quad \mathop {\lim }\limits_{|x|\to \infty } u(x) = 0.$$
A classical existence result by Berestycki and Lions [3] considers only the case when f is continuous. In this paper, we are interested in the existence of a solution when f is singular. For a singular nonlinearity f, Gazzola, Serrin and Tang [8] proved an existence result when $f \in L^1_{loc}(\mathbb {R}) \cap \mathrm {Lip}_{loc}(0,\infty )$ with $\int _0^u f(s)\,{\rm d}s < 0$ for small $u>0.$ Since they use a shooting argument for their proof, they require the property that $f \in \mathrm {Lip}_{loc}(0,\infty ).$ In this paper, using a purely variational method, we extend the previous existence results for $f \in L^1_{loc}(\mathbb {R}) \cap C(0,\infty )$. We show that a solution obtained through minimization has the least energy among all radially symmetric weak solutions. Moreover, we describe a general condition under which a least energy solution has compact support.
Mono- vs multifilament gillnets: effects on selectivity of narrow-barred Spanish mackerel Scomberomorus commerson in the Persian Gulf
Authors: Eighani Morteza , Bayse Shannon M. , Paighambari Seyed Yousef , Broadhurst Matt K. 
Published: January 2020

AbstractIranian coastal fishers targeting narrow-barred Spanish mackerel (Scomberomorus commerson) recently replaced their historical multifilament gillnets with those made from monofilament, evoking management concerns over potential increases in catch-per-unit-of-effort. During 20 fishing days, we compared catches from replicate surface-set gillnets that were identical in terms of mesh size (140 mm stretched opening), length (180 m), depth (30 m), hanging ratio (0.56) and spatio-temporal deployment, but had different materials: multifilament (1.8-mm diameter twisted twine) vs monofilament (0.8-mm diameter twine). Compared with the multifilament gillnet, there was a trend of greater catches (up to 1.3×) of S. commerson and another retained species, mackerel tuna (Euthnus affinis), along with one discarded species, giant catfish (Netuma thalassina) by the monofilament gillnet. However, statistical significance was restricted to E. affinis catches and a bias towards smaller S. commerson. These differences were attributed to species-specific catching mechanisms within gillnet material, with larger S. commerson retained by their teeth in the multifilament and all E. affinis more securely retained by their deeper bodies in the monofilament. Gillnet materials require regulation to preclude excessive effort on fully exploited stocks of species such as S. commerson.
Outcome of Conventional Bystander Cardiopulmonary Resuscitation in Cardiac Arrest Following Drowning
Authors: Tobin Joshua M. , Ramos William D. , Greenshields Joel , Dickinson Stephanie , Rossano Joseph W. , Wernicki Peter G. , Markenson David , Vellano Kimberly , McNally Bryan ,   CARES Surveillance Group
Published: January 2020

AbstractIntroduction:The concept of compressions only cardiopulmonary resuscitation (CO-CPR) evolved from a perception that lay rescuers may be less likely to perform mouth-to-mouth ventilations during an emergency. This study hopes to describe the efficacy of bystander compressions and ventilations cardiopulmonary resuscitation (CV-CPR) in cardiac arrest following drowning.Hypothesis/Problem:The aim of this investigation is to test the hypothesis that bystander cardiopulmonary resuscitation (CPR) utilizing compressions and ventilations results in improved survival for cases of cardiac arrest following drowning compared to CPR involving compressions only.Methods:The Cardiac Arrest Registry for Enhanced Survival (CARES) was queried for patients who suffered cardiac arrest following drowning from January 1, 2013 through December 31, 2017, and in whom data were available on type of bystander CPR delivered (ie, CV-CPR CO-CPR). The primary outcome of interest was neurologically favorable survival, as defined by cerebral performance category (CPC).Results:Neurologically favorable survival was statistically significantly associated with CV-CPR in pediatric patients aged five to 15 years (aOR = 2.68; 95% CI, 1.10–6.77; P = .03), as well as all age group survival to hospital discharge (aOR = 1.54; 95% CI, 1.01–2.36; P = .046). There was a trend with CV-CPR toward neurologically favorable survival in all age groups (aOR = 1.35; 95% CI, 0.86–2.10; P = .19) and all age group survival to hospital admission (aOR = 1.29; 95% CI, 0.91–1.84; P = .157).Conclusion:In cases of cardiac arrest following drowning, bystander CV-CPR was statistically significantly associated with neurologically favorable survival in children aged five to 15 years and survival to hospital discharge.
Secularization Theory and Religion
Authors: Dhima Kostanca , Golder Matt 
Published: January 2020

AbstractWhat is the relationship between religion and human development? Using data from the pooled 1981–2014 World and European Values Surveys, we examine the effect of human development on a country's level of religious attendance and belief. Consistent with the idea that the primary causal mechanism underlying secularization theory has to do with the substitutability of secular and religious goods, we find that human development has a negative effect on religious attendance but no effect on religious belief. Our results indicate that as societies develop, we should not be surprised if religious belief remains high even as religious attendance declines. The negative effect of human development on religious attendance is driven primarily by a country's level of education and health. Our analysis suggests that it is important to think carefully about what one's theoretical model of the secularization process implies for different aspects of religion.
Validity and Cross-Cultural Invariance of the Resiliency Scale for Young Adults – Spanish Version
Authors: Plouffe Rachel A. , Dave Hiten P. , Wilson Claire A. , Topa Gabriela , Riggin Alex , Lau Chloe , Sinclair Vanessa M. , Saklofske Donald H. , Prince-Embury Sandra 
Published: January 2020

Abstract. Emerging adulthood represents a time of substantial change and unpredictability. Personal resiliency is defined as an ability to adapt and thrive in the face of challenging circumstances. This study evaluated the cross-cultural validity of a new Spanish translation of the Resiliency Scale for Young Adults (RSYA) using samples of 393 young adults (66.2% women) from Spain (ages 18–30 years, Mage = 25.88, SDage = 2.87) and 365 young adults (71.23% women) from Canada (ages 18–30 years, Mage = 18.56, SDage = 1.26). Results showed that scores on the Spanish RSYA demonstrated high internal consistency reliability, convergent validity, a sound three-factor structure, and partial scalar invariance. Overall, the RSYA translation is a promising theory-based measurement tool designed for use in Spanish young adult samples.
The German Version of the Multidimensional Acculturative Stress	Inventory (MASI) for Turkish-Origin Immigrants
Authors: Scholaske Laura , Rodriguez Norma , Sari Nida Emel , Spallek Jacob , Ziegler Matthias , Entringer Sonja 
Published: January 2020

Abstract. The Multidimensional Acculturative Stress Inventory (MASI) is an established measure of acculturative stress for people of Mexican origin living in the USA that has been associated with mental health outcomes in this population. We translated the MASI into German and adapted it for use with Turkish-origin immigrants in Germany. The MASI includes filter questions asking if a potentially stressful event had actually occurred before reporting the stress appraisal of these situations. Measurement invariance testing has become a standard practice to evaluate questionnaire translations, however, measurement invariance of filter questions has been scarcely studied. In Study 1, we evaluated measurement invariance of the filter questions between a German-based Turkish sample ( N = 233) and the Mexican-origin sample from the original study ( N = 174) and could show partial strong factorial invariance for three of the four factors. In Study 2, a validation study, relations between the German MASI scores and measures of acculturation and stress indicated discriminant validity. This study contributes to research on measurement invariance of filter questions, thereby providing a measure of acculturative stress that can be used in future research to understand the etiology of health disparities in Turkish-origin immigrants in Germany.
Probing Slow Earthquakes With Deep Learning
Authors: Rouet‐Leduc Bertrand , Hulbert Claudia , McBrearty Ian W. , Johnson Paul A. 
Published: January 2020

AbstractSlow earthquakes may trigger failure on neighboring locked faults that are stressed sufficiently to break, and slow slip patterns may evolve before a nearby great earthquake. However, even in the clearest cases such as Cascadia, slow earthquakes and associated tremor have only been observed in intermittent and discrete bursts. By training a convolutional neural network to detect known tremor on a single seismic station in Cascadia, we isolate and identify tremor and slip preceding and following known larger slow events. The deep neural network can be used for the detection of quasi‐continuous tremor, providing a proxy that quantifies the slow slip rate. Furthermore, the model trained in Cascadia recognizes tremor in other subduction zones and also along the San Andreas Fault at Parkfield, suggesting a universality of waveform characteristics and source processes, as posited from experiments and theory.
Pantropical Response to Global Warming and the Emergence of a La Niña‐Like Mean State Trend
Authors: Lee Sang‐Ki , Kim Dongmin , Foltz Gregory R. , Lopez Hosmay 
Published: January 2020

AbstractA recent study by Zhang et al. (2019, https://doi.org/10.1029/2019GL084088) proposes “an interbasin ocean thermostat mechanism” to support the hypothesis that enhanced Indian Ocean warming during the past century has reduced the Pacific warming response to increasing greenhouse gases. In this commentary, we review the proposed mechanism in a broader perspective and discuss a potential role of Atlantic Ocean in modulating the future Pacific warming response to emphasize the interactive response of the pantropical atmosphere‐ocean to increasing greenhouse gases.
Intensification of the Atlantic Water Supply to the Arctic Ocean Through Fram Strait Induced by Arctic Sea Ice Decline
Authors: Wang Qiang , Wekerle Claudia , Wang Xuezhu , Danilov Sergey , Koldunov Nikolay , Sein Dmitry , Sidorenko Dmitry , von Appen Wilken‐Jon , Jung Thomas 
Published: January 2020

AbstractSubstantial changes have occurred in the Arctic Ocean in the last decades. Not only sea ice has retreated significantly, but also the ocean at middepth showed a warming tendency. By using simulations we identified a mechanism that intensifies the upward trend in ocean heat supply to the Arctic Ocean through Fram Strait. The reduction in sea ice export through Fram Strait induced by Arctic sea ice decline increases the salinity in the Greenland Sea, which lowers the sea surface height and strengthens the cyclonic gyre circulation in the Nordic Seas. The Atlantic Water volume transport to the Nordic Seas and Arctic Ocean is consequently strengthened. This enhances the warming trend of the Arctic Atlantic Water layer, potentially contributing to the Arctic “Atlantification.” Our study suggests that the Nordic Seas can play the role of a switchyard to influence the heat budget of the Arctic Ocean.
A Dynamic Blending Scheme to Mitigate Large‐Scale Bias in Regional Models
Authors: Feng Jin , Sun Juanzhen , Zhang Ying 
Published: January 2020

AbstractSeveral blending methods have been developed in dynamic downscaling and rapid cycled data assimilation. Blending the large‐scale part of the global model (GM) analysis or forecast has led to improvement in regional model (RM) simulations. However, in previous studies the blended waveband of the GM has generally been determined using a fixed, arbitrarily chosen cutoff wave number. Here we introduce a new dynamic blending (DB) scheme with a dynamic cutoff wave number computed according to the spectral characteristics of GM forecast quality and the spectral distribution of errors in the RM. The DB scheme is described and applied to eight‐day summertime and seven‐day wintertime cycled Weather Research and Forecasting Model forecasts over a regional domain in the continental United States. The scheme can determine a cutoff wave number with significant temporal variations. The temporal variation results from the error growth property of the RM and has a clear diurnal oscillation, suggesting that fewer (more) GM waves should be introduced into the RM at noon (night). The cutoff wave number difference between the two periods indicates seasonal variation of the cutoff wave number with larger day‐to‐day change in winter. Comparison among no blending experiment, two fixed wave number blending experiments, and two DB experiments with and without vertically varying cutoff wave number suggests that the DB scheme with vertically averaged but temporally varying cutoff wave number results in less model bias and less disturbance to the RM dynamic balance. By reducing the forecast background error, the DB scheme can potentially provide improved first guess for a rapid‐update‐cycle weather forecast system.
Anticancer activity of dietary xanthone α-mangostin against hepatocellular carcinoma by inhibition of STAT3 signaling via stabilization of SHP1
Authors: Zhang Hai , Tan Yu-ping , Zhao Lin , Wang Lun , Fu Nai-jie , Zheng Song-ping , Shen Xiao-fei 
Published: January 2020

AbstractHepatocellular carcinoma (HCC) is one of the most lethal human cancers worldwide. The dietary xanthone α-mangostin (α-MGT) exhibits potent anti-tumor effects in vitro and in vivo. However, the anti-HCC effects of α-MGT and their underlying mechanisms are still vague. Aberrant activation of signal transducer and activator of transcription 3 (STAT3) is involved in the progression of HCC. We therefore investigated whether α-MGT inhibited the activation of STAT3 and thereby exhibits its anti-HCC effects. In this study, we found that α-MGT significantly suppressed cell proliferation, induced cell cycle arrest, and triggered apoptosis in HCC cells, including HepG2, SK-Hep-1, Huh7, and SMMC-7721 cells in vitro, as well as inhibiting tumor growth in nude mice bearing HepG2 or SK-Hep-1 xenografts. Furthermore, α-MGT potently inhibited the constitutive and inducible activation of STAT3 in HCC cells. In addition, α-MGT also suppressed IL-6-induced dimerization and nuclear translocation of STAT3, which led to inhibition of the expression of STAT3-regulated genes at both mRNA and protein levels. Mechanistically, α-MGT exhibited effective inhibition of the activation of STAT3’s upstream kinases, including JAK2, Src, ERK, and Akt. Importantly, α-MGT increased the protein level of Src homology region 2 domain-containing phosphatase-1 (SHP1), which is a key negative regulator of the STAT3 signaling pathway. Furthermore, α-MGT enhanced the stabilization of SHP1 by inhibiting its degradation mediated by the ubiquitin–proteasome pathway. Knockdown of SHP1 using siRNA obviously prevented the α-MGT-mediated inhibition of the activation of STAT3 and proliferation of HCC cells. In summary, α-MGT exhibited a potent anti-HCC effect by blocking the STAT3 signaling pathway via the suppression of the degradation of SHP1 induced by the ubiquitin–proteasome pathway. These findings also suggested the potential of dietary derived α-MGT in HCC therapy.