bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generative BIM workspace for AEC conceptual design automation: prototype development
Authors: Abrishami Sepehr , Goulding Jack , Rahimian Farzad 
Published: July 2020

PurposeThe integration and automation of the whole design and implementation process have become a pivotal factor in construction projects. Problems of process integration, particularly at the conceptual design stage, often manifest through a number of significant areas, from design representation, cognition and translation to process fragmentation and loss of design integrity. Whilst building information modelling (BIM) applications can be used to support design automation, particularly through the modelling, amendment and management stages, they do not explicitly provide whole design integration. This is a significant challenge. However, advances in generative design now offer significant potential for enhancing the design experience to mitigate this challenge.Design/methodology/approachThe approach outlined in this paper specifically addresses BIM deficiencies at the conceptual design stage, where the core drivers and indicators of BIM and generative design are identified and mapped into a generative BIM (G-BIM) framework and subsequently embedded into a G-BIM prototype. This actively engages generative design methods into a single dynamic BIM environment to support the early conceptual design process. The developed prototype followed the CIFE “horseshoe” methodology of aligning theoretical research with scientific methods to procure architecture, construction and engineering (AEC)-based solutions. This G-BIM prototype was also tested and validated through a focus group workshop engaging five AEC domain experts.FindingsThe G-BIM prototype presents a valuable set of rubrics to support the conceptual design stage using generative design. It benefits from the advanced features of BIM tools in relation to illustration and collaboration (coupled with BIM's parametric change management features).Research limitations/implicationsThis prototype has been evaluated through multiple projects and scenarios. However, additional test data is needed to further improve system veracity using conventional and non-standard real-life design settings (and contexts). This will be reported in later works.Originality/valueOriginality and value rest with addressing the shortcomings of previous research on automation during the design process. It also addresses novel computational issues relating to the implementation of generative design systems, where, for example, instead of engaging static and formal description of the domain concepts, G-BIM actively enhances the applicability of BIM during the early design stages to generate optimised (and more purposeful) design solutions.
Entrepreneurial decision-making and family social capital
Authors: Wang Cizhi , Flamini Giulia , Wang Kai , Pei Rong , Chen Chiyin 
Published: July 2020

PurposeThe purpose of this paper is to adopt a collective perspective in the study of entrepreneurial decision-making processes and empirically analyse the ways in which social relationships between family members can shape their collective entrepreneurial decision-making behaviour (ED).Design/methodology/approachThis paper considers the family social capital (FSC) in inducing overall conformity to the focal family member's decision to exploit an opportunity. In terms of the seminal construct of social capital, the authors propose three FSC dimensions that can be used to induce conformity: structural, relational and cognitive dimensions. Then, the authors design questionnaires to collect data pertaining to the relationships between the family members' ED and the FSC. Finally, the authors collect 152 valid questionnaires from Chinese family firms.FindingsThe data analysis consists of two parts. The first section of this paper analyses conformity by testing the discriminant validity of models. Regression analysis is then used to test the relationship between family members' ED and the FSC. Significant relationships between the cognitive dimension of FSC and the entrepreneur's decision-making are found.Originality/valueThe research contributes towards academic literature concerning both entrepreneurship and social capital. On the one hand, this paper is one of the rare pieces of entrepreneurial research that responds to the call for the study of entrepreneurship from a collective perspective. On the other hand, our study quantitatively tests the impact of FSC at a multidimensional level. It provides conclusions regarding the social influence of other family members and provides insights into social capital by studying entrepreneurship from a social/community perspective.
Inferring individual fate from aquatic acoustic telemetry data
Authors: Villegas‐Ríos David , Freitas Carla , Moland Even , Thorbjørnsen Susanna Huneide , Olsen Esben M. 
Published: July 2020

AbstractAcoustic telemetry has become a popular means of obtaining individual behavioural data from a wide array of species in marine and freshwater systems. Fate information is crucial to understand important aspects of population dynamics such as mortality, predation or dispersal rates.Here we present a method to infer individual fate from acoustic telemetry arrays of receivers with overlapping detection ranges. Our method depends exclusively on information on animal movements and the characteristics and configuration of the telemetry equipment. By answering a limited number of simple questions, our method identifies six different fates: tagging mortality, natural mortality, fishing mortality, predation, dispersal and survival.Applying the method to a cod telemetry dataset, we were able to determine the fate of 97% of the individuals. We validate the results using several external sources of information, such as recaptures from fishers and control fish with known fate.The method is readily applicable to a wide array of species with minimal adjustments, expanding the range of hypotheses that can be tested using telemetry data.
Chronic fluoxetine or ketamine treatment differentially affects brain energy homeostasis which is not exacerbated in mice with trait suboptimal mitochondrial function
Authors: Emmerzaal Tim L. , Jacobs Leah , Geenen Bram , Verweij Vivienne , Morava Eva , Rodenburg Richard J. , Kozicz Tamas 
Published: July 2020

AbstractAntidepressants have been shown to influence mitochondrial function directly, and suboptimal mitochondrial function (SMF) has been implicated in complex psychiatric disorders. In the current study, we used a mouse model for trait SMF to test the hypothesis that chronic fluoxetine treatment in mice subjected to chronic stress would negatively impact brain bioenergetics, a response that would be more pronounced in mice with trait SMF. In contrast, we hypothesized that chronic ketamine treatment would positively impact mitochondrial function in both WT and mice with SMF. We used an animal model for trait SMF, the Ndufs4GT/GT mice, which exhibit 25% lower mitochondrial complex I activity. In addition to antidepressant treatment, mice were subjected to chronic unpredictable stress (CUS). This paradigm is widely used to model complex behaviours expressed in various psychiatric disorders. We assayed several physiological indices as proxies for the impact of chronic stress and antidepressant treatment. Furthermore, we measured brain mitochondrial complex activities using clinically validated assays as well as established metabolic signatures using targeted metabolomics. As hypothesized, we found evidence that chronic fluoxetine treatment negatively impacted brain bioenergetics. This phenotype was, however, not further exacerbated in mice with trait SMF. Ketamine did not have a significant influence on brain mitochondrial function in either genotype. Here we report that trait SMF could be a moderator for an individual's response to antidepressant treatment. Based on these results, we propose that in individuals with SMF and comorbid psychopathology, fluoxetine should be avoided, whereas ketamine could be a safer choice of treatment.
Adults with Down syndrome challenge another paradigm: When aging no longer entails arterial hypertension
Authors: Roy‐Vallejo Emilia , Galván‐Román José María , Moldenhauer Fernando , Real de Asúa Diego 
Published: July 2020

AbstractThe paradigmatic relationship between aging and atherosclerotic cardiovascular events does not apply to all patient populations. Though trisomy 21 (T21) and its phenotypic expression, Down syndrome (DS), are conditions that involve premature aging, the cardiovascular system of adults with DS appears to be particularly spared from this early senescence. Despite a higher prevalence of some classic cardiovascular risk factors in adults with DS than in the general population, such as dyslipidemia, obesity, or sedentarism, these individuals do not develop hypertension or suffer major cardiovascular events as they age. The protective factors that prevent the development of hypertension in T21 are not well established. Genes like RCAN1 and DYRK1A, both on chromosome 21 and over‐expressed in adults with DS, appear to play a major role in cardiovascular prevention. Their regulation of the renin‐angiotensin‐aldosterone system (RAAS) and neprilysin synthesis could underlie the constitutive protection against arterial hypertension in adults with DS and explain the absence of increased arterial stiffness in this population. A better understanding of these molecular pathways could have enormous implications for the clinical management of adults with DS and might foster the development of novel therapeutic targets in cardiovascular prevention for the general population.
Hemodynamics of different volumes of red blood cell transfusion in preterm infants
Authors: Choi Eui Kyung , Shin Jeonghee , Kim Gun‐Ha , Choi Byung Min 
Published: July 2020

AbstractBackgroundAlthough many controversies exist regarding the risk of red blood cell (RBC) transfusions, half of preterm infants born at <32 weeks of gestational age receive such transfusions because of anemia of prematurity. Because of the costs and risks associated with multiple transfusions, it has been suggested that a large transfusion volume reduces the number of transfusions. However, there have been persistent concerns that RBC transfusion might lead to volume overload.MethodsWe examined the impacts of large (20 mL/kg) compared to standard volume (15 mL/kg) transfusions on the hemodynamic variables of stable, electively transfused, preterm infants, by serially measuring echocardiographic parameters and plasma B‐type natriuretic peptide levels.ResultsA total of 39 infants born at <34 weeks of gestation and aged >2 weeks at the time of enrollment were randomly allocated to either a standard volume (15 mL/kg) or a large volume (20 mL/kg) group. Significant reductions in cardiac output and transient increases in plasma B‐type natriuretic peptide levels were found after RBC transfusion in both the standard and large volume (20 mL/kg) groups. However, these changes were not significantly different between the two groups.ConclusionsLarge‐volume transfusions could be tolerable in stable preterm infants with anemia.
Fungal infection risks associated with the use of cytokine antagonists and immune checkpoint inhibitors
Authors: Li Xin , Lau Susanna KP , Woo Patrick CY 
Published: July 2020

The revolutionary success of biologic agents in treating various malignant and autoimmune conditions has been met with increased risk of opportunistic infections due to perturbations in immunity. In patients receiving biologic-containing regimens, the risk of fungal infection is less well-understood, and there is a lack of established guideline on the standard of care in terms of screening and prophylaxis. In this article, we reviewed the risk of fungal infections associated with cytokine antagonists, including anti-tumor necrosis factor (TNF) agents and interleukin (IL) antagonists, and immune checkpoint inhibitors. The risk of fungal infection in this group of patients is drug-, pathogen-, host-, and context-dependent. Among the biologic agents reviewed, anti-TNF agents are associated with highest number of reported cases of fungal infection, especially histoplasmosis. In fact, infection due to all dimorphic fungi except Talaromyces marneffei have been reported in patients receiving TNF-α inhibitors, despite their widespread use in T. marneffei-endemic regions. The risk is higher with TNF-α inhibitors that block both the membrane-bound and soluble forms of TNF-α, i.e., infliximab and adalimumab, compared with etanercept which inhibits the soluble form only. In addition to the preferential suppression of Th1 pathway and granuloma formation leading to genuinely higher risk of infection, the longer history and extensive use of infliximab coupled with the endemicity of histoplasmosis in the United States lead to an apparent increase in reported cases. IL-17 antagonists lead to a moderate increase in mucocutaneous candidiasis, but not the risk of life-threatening mycosis, consistent with the essential role of Th17 cells in mucosal defense. Immune checkpoint inhibitors, on the other hand, do not significantly increase the risk of invasive fungal infections when used alone and may even be of therapeutic value in the treatment of severe and refractory mycosis.Impact statementThe risk of opportunistic infections due to fungi is relatively less well addressed in patients receiving biologic agents, compared with other opportunistic bacterial and viral infections. There is a lack of consensus guideline on the screening, prophylaxis, and management of fungal infection in patients anticipated to receive or actively receiving biologic therapy. In addition, invasive mycosis in immunocompromised patients is associated with high mortality and morbidity. This review highlighted the risk of fungal infection in patients receiving cytokine antagonists and immune checkpoint inhibitors, two big categories of biologic agents that are widely used in the treatment of various autoimmune and malignant conditions, often in combination with other immunomodulatory or immunosuppressive agents but also as standalone therapy. The adverse outcomes of opportunistic fungal infection in these patients can be reduced by heightened awareness, active case finding, and prompt treatment.
A mobile app for Glaucoma diagnosis and its possible clinical applications
Authors: Guo Fan , Li Weiqing , Zhao Xin , Qiu Junfeng , Mai Yuxiang 
Published: July 2020

Abstract
Background
Nowadays, the latent power of technology, which can offer innovative resolutions to disease diagnosis, has awakened high-level anticipation in the community of patients as well as professionals. An easy-to-use mobile app is developed by us, which is purposefully intended for those patients with glaucoma.

Methods
A mobile App has been invented for smartphones for the convenient use wherever and whenever. The corresponding experiments carried out by public retinal image database and real captured clinical data reveal the ideal classification accuracy of the App. Also, user feedback evaluation is also carried out in terms of performance test as well as and users’ experience.

Results
For clinical test using Yanbao App, we found 274 patients for the identification with 648 retinal images to be evaluated by glaucoma classification. Of the 243 glaucoma patients, 191 were screened out with an accuracy of 0.7860 (sensitivity); the number of non-glaucoma patients was 310 of 405, and the accuracy reached 0.7654 (specificity).` The total Accuracy amounted to 0.7731, and the result is close to the test performance obtained on public dataset ORIGA and DRISHTI-GS1.

Conclusions
Yanbao App can be applied as an innovative approach exploiting mobile technology to enhance the clinicians’ efficiency and a balanced medical resources as well as a provided better tiered medical service system.
COVID-19 Pandemic in Nigeria: Palliative Measures and the Politics of Vulnerability
Authors: Eranga Isaac Omo-Ehiabhi 
Published: July 2020

In a bid to slow the rate of spread of the virus, the Federal Government of Nigeria, on several occasions, imposed targeted lockdown measures in areas with rapid increase of Covid-19 cases. The states in which the federal government imposed the targeted lockdown included Lagos, Ogun, and the Federal Capital Territory in Abuja. Some States in the country imposed partial lockdown and closure of interstate boarders. Curfews have also been introduced in all the states nationwide. To alleviate the effects of the lockdown, the Federal Government of Nigeria rolled out palliative measures for targeted groups. However, lamentations have trailed the distribution of government palliatives by the masses. Citizens allege that the process of distribution of palliatives had been politicized.
Key words: • Corona virus • Covid-19 • Nigeria • Palliatives

Copyright © 2020 Eranga. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in this journal, is properly cited.
Cholera in the Time of MINUSTAH: Experiences of Community Members Affected by Cholera in Haiti
Authors: Bartels Susan , Fraulin Georgia , Lee Sabine 
Published: July 2020

Abstract

Background: In October 2010, 10 months after a catastrophic earthquake, Haiti experienced the largest and most deadly cholera outbreak of the 21st century with 820,000 reported cases and up to 10,000 deaths. Nepalese United Nations (UN) peacekeepers are widely believed to have introduced cholera, and the UN formally accepted responsibility for the outbreak in 2016. The current analysis examines how Haitian community members experienced the cholera epidemic and documents their attitudes around accountability and delayed reparations from the UN.Methods: Using a narrative capture tool, 12 Haitian research assistants collected micronarratives in 2017 from participants surrounding 10 UN bases in Haiti. Seventy-seven micronarratives focused on cholera were selected for thematic analysis, which was conducted by two independent coders. Relevant stories were chosen to present a diverse selection of experiences and attitudes related to cholera.Results: Five major themes were identified: 1) Cholera cases and deaths; 2) Accessing care and services; 3) Protests and riots against the UN; 4) Reparations; and 5) Anti-colonialism. Findings highlight the fear and frustration caused by the cholera outbreak and the devastating impact it had on affected families and communities, which was compounded in some cases by an inability to access life-saving medical care. Widespread anger against the UN was also evident and led to protests and riots against the peacekeepers. Most participants believed that the UN should compensate cholera victims but there was significant misinformation about the reparation process. The UN’s culpability in the cholera epidemic provoked anti-colonial sentiments and a call to end the UN’s ‘occupation’ of Haiti.Conclusions: Haiti’s cholera victims and their families deserve clear and transparent updates from the UN and the committed material compensation for cholera must be delivered to affected families. Focused investments to improve access to safe water and adequate sanitation must be instituted to eradicate cholera in Haiti. To rebuild trust in the UN and foreign aid, the committed material compensation must be provided in partnership with local Haitians organizations who consult with community members throughout each step of the process.
New insights into the crystal chemistry of sauconite (Zn-smectite) from the Skorpion zinc deposit (Namibia) via a multi-methodological approach
Authors: Schingaro Emanuela , Ventruti Gennaro , Vinci Doriana , Balassone Giuseppina , Mondillo Nicola , Nieto Fernando , Lacalamita Maria , Leoni Matteo 
Published: July 2020

AbstractA multi-methodical characterization of a sauconite (Zn-bearing trioctahedral smectite) specimen from the Skorpion ore deposit (Namibia) was performed by combining X-ray powder diffraction (XRPD), cation exchange capacity (CEC) analysis, differential thermal analysis (DTA), thermo-gravimetry (TG), Fourier transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM-HRTEM-AEM). The X-ray diffraction pattern exhibits the typical features of turbostratic stacking disorder with symmetrical basal 00l reflections and long-tailed hk bands, as confirmed by TEM observations. Besides sauconite, the sample contains minor amounts of kaolinite, dioctahedral smectite, and quartz. CEC analysis provides a total of Ca (~69%), Mg (~26%), Na (~4%), and K (0.7%) exchangeable cations. Therefore, Zn is located exclusively within the octahedral site of sauconite. TG analysis of the sample yields a total mass loss of about 17%. Three endothermic peaks can be observed in the DTA curve, associated with dehydration and dehydroxylation of the material. An exothermic peak at 820 °C is also present as a consequence of decomposition and recrystallization. The infrared spectrum shows the typical Zn3OH stretching signature at 3648 cm–1, whereas, in the OH/H2O stretching region two bands at 3585 and 3440 cm–1 can be attributed to stretching vibrations of the inner hydration sphere of the interlayer cations and to absorbed H2O stretching vibration, respectively. Diagnostic bands of kaolinite impurity at ~3698 and 3620 cm–1 are also found, whereas 2:1 dioctahedral layer silicates may contribute to the 3585 and 3620 cm–1 bands. Finally, using the one-layer supercell approach implemented in the BGMN software, a satisfactory XRPD profile fitting model for the Skorpion sauconite was obtained. These findings have implications not only for economic geology/recovery of critical metals but also, more generally, in the field of environmental sciences.
Penyembuhan Baby Blues Syndrome dan Post-Partum Depression Melalui Chandra Namaskara dan Brahmari Pranayama
Authors: Dewi Ni Wayan Sri Prabawati Kusuma 
Published: July 2020

<p>Babies born through both normal and caesarean (sc) procedures, 50-80% make the mother face the risk of baby blues syndrome and post-partum depression. Baby blues syndrome, occurs in the first 2 weeks after giving birth, triggered by physical changes such as swelling of the breast, pain in the area around the birth canal and uterus, changes in muscle tone, physical and mental fatigue that the mother feels. While post-partum depression lasts several months to many years later, this syndrome begins with a psychiatric disorder suffered by the mother before pregnancy, psychosocial stress, inadequate social support, and premenstrual dysphoric disorder. For that, this condition needs to be addressed immediately, through the healing techniques of Chandra namaskara and Brahmari Pranayama. Chandra namaskara arouses the feminine energy, the lunar energy in the mother’s body, keeping the cerebral circulation fresh so that the sympathetic nerve activity diminishes. The effect of massage on the organs in the abdomen, increase peristaltic activity in the intestine, the lateral wall of the heart stretched perfectly so that no ischaemia occurs. Alteration of arthritis of the spinal joint can be removed by stretching the spinal muscles and ligaments between the vertebral bones through this series of asanas. While brahmari pranayama stimulates the brain part of the hypothalamus to activate the adrenal cortex system by sending signals to the pituitary gland so as not to secrete adrenocorticotropin (ACTH), so that ACTH, which had previously stimulated the outer layer of the adrenal glands (the adrenal cortex) to release a group of hormones (cortisol) did not secrete cortisol, but instead produced by the brain is actually the endhorpine that works for the body’s immune, regulate emotions, relax of the body and be able to eliminate depression.</p><p><br /><br /></p>