bluuebunny/crossref_metadata_2025_split huggingface dataset:
Konjac glucomannan polysaccharide and inulin oligosaccharide enhance the colonic mucosal barrier function and modulate gut-associated lymphoid tissue immunity in C57BL/6J mice
Authors: Changchien Chih-Hsuan , Han Yi-Chun , Chen Hsiao-Ling 
Published: November 2019

AbstractBoth konjac glucomannan (KGM) and inulin oligosaccharide have been shown to improve bowel function, but their effects on the mucosal barrier function and immunity are not fully understood. The aim of the present study was to determine the effects of a low-level supplementation of dietary fibres on the colonic mucosal barrier function, antioxidant enzyme defence and immunity. C57BL/6J mice (6 weeks of age, eight per group) were randomly assigned to consume one of the following diets: control or control diet supplemented with 2 % (w/w) of KGM, inulin oligosaccharide (degree polymerisation = 8) or KGM+inulin (1 %, w/w each (K+I)). Fresh faeces were collected on days 19–21. Mice were killed on day 22 after fasting. Segments of colon tissues were processed for histological procedure and stained for acidic mucins and tight junction protein marker zona occludin-1 (ZO-1). The remaining tissues were processed to determine the gene expression of mucin 2, tight junction proteins, antioxidant enzymes and cytokines. The plasma cytokines were measured. Results indicated that KGM, inulin and K+I significantly increased the mucosal layer thickness, mucin density (granule number/crypt) and gene expression of Muc2 as compared with the control. All fibre treatments increased the gene expressions of ZO-1, occludin, glutathione peroxidase, glutathione S-transferase π, catalase and IL-10. In addition, all fibre treatments increased faecal butyrate and probiotics, and plasma IL-10 concentrations. In conclusion, supplementation of low-level, 2 % (w/w), of K+I was sufficient to enhance the mucosal barrier function and anti-inflammatory status.
The turn to history in international law and the sources doctrine: Critical approaches and methodological imaginaries
Authors: Arvidsson Matilda , Bak McKenna Miriam 
Published: November 2019

AbstractExpanding now familiar debates about the impact of the ‘historical turn’ upon the field of international law, this article considers some of the different ways in which ‘turn to history’ scholars have confronted the methodological and theoretical tensions arising from the central, yet paradoxical, role occupied by the sources doctrine in international law. We suggest that the anxiety over the sources of international law as the basic methodological precepts of the discipline has been a catalyzing element for a radical reengagement with the canon of international law, one with a significant impact on the field’s existing parameters and doctrinal limits. Within the three streams of scholarship we explore here, history has become a site of creative engagement for scholars in opening up the discipline to diverse ends, one in which a new doctrinal universe can be created, and new issues, sources, subjects, and approaches can be explored. Yet, by opening up international law’s sources doctrine, reactionary causes and unjust ends may equally well be the result. This account is an attempt at diversifying the narrative surrounding the causal relationship between history and the ongoing changes to the field of international law, along with the differential practices, techniques and epistemological foundations behind the history of international law as an evolving discipline, and of the different scholarly motivations of its specialists.
Assessment of Executive Functioning in Patients with Meningioma and Low-Grade Glioma: A Comparison of Self-Report, Proxy-Report, and Test Performance
Authors: van der Linden Sophie Dorothee , Gehring Karin , De Baene Wouter , Emons Wilco Henricus Maria , Rutten Geert-Jan Maria , Sitskoorn Margriet Maria 
Published: November 2019

AbstractObjective:This study aimed to examine: (1) patient–proxy agreement on executive functioning (EF) of patients with primary brain tumors, (2) the relationships between patient- and proxy-report with performance-based measures of EF, and (3) the potential influence of performance-based measures on the level of agreement.Methods:Meningioma and low-grade glioma patients and their informal caregivers completed the Behavior Rating Inventory of Executive Function (BRIEF-A) 3 months after surgery. The two index scores of the BRIEF-A, Behavioral Regulation and Metacognition, were evaluated. Mean scores of patients and proxies were compared with normative values and with each other. Patient–proxy agreement was evaluated with Lin’s concordance correlation coefficients (CCCs) and Bland–Altman plots. Pearson correlation coefficients between reported EF and performance-based measures of EF were calculated. Multiple regression analysis was used to evaluate the potential influence of test performance on differences in dyadic reports.Results:A total of 47 dyads were included. Patients reported significantly more problems on the Metacognition Index compared to norms, and also in comparison with their proxies. Effect sizes indicated small differences. Moderate to substantial agreement was observed between patients and proxies, with CCCs of 0.57 and 0.61 for Metacognition and Behavioral Regulation, respectively. Correlations between reported EF and test performance ranged between −0.37 and 0.10. Dyadic agreement was not significantly influenced by test performance.Conclusions:Patient–proxy agreement was found to be moderate. No clear associations were found between reported EF and test performance. Future studies should further explore the existing and new methods to assess everyday EF in brain tumor patients.
THE -MODULAR LOCAL LANGLANDS CORRESPONDENCE AND LOCAL CONSTANTS
Authors: Kurinczuk R. , Matringe N. 
Published: November 2019

AbstractLet $F$ be a non-archimedean local field of residual characteristic $p$, $\ell \neq p$ be a prime number, and $\text{W}_{F}$ the Weil group of $F$. We classify equivalence classes of $\text{W}_{F}$-semisimple Deligne $\ell$-modular representations of $\text{W}_{F}$ in terms of irreducible $\ell$-modular representations of $\text{W}_{F}$, and extend constructions of Artin–Deligne local constants to this setting. Finally, we define a variant of the $\ell$-modular local Langlands correspondence which satisfies a preservation of local constants statement for pairs of generic representations.
Identification of Source‐Water Oxygen Isotopes in Trees Toolkit (ISO‐Tool) for Deciphering Historical Water Use by Forest Trees
Authors: Sargeant Christopher I. , Singer Michael Bliss , Vallet‐Coulomb Christine 
Published: November 2019

AbstractHydrological regimes are being perturbed under climate change due to the regional expression of the water cycle across the globe, leading to alterations in the spatial and temporal distribution of water near the Earth's surface. Water is a critical resource for plant ecosystems, and hydrological limitations on vegetative health are particularly complex. To anticipate how subsurface water availability may evolve in the future and affect the dynamics of plant water source usage, as well as the health and functioning of vegetation in various biomes, we need a robust, quantitative framework for linking water availability to past plant water use, which is constrained by historical data. Here, we outline the Identification of Source‐water Oxygen isotopes in trees Toolkit (ISO‐Tool), designed to retrospectively investigate the dynamics of tree water uptake. ISO‐Tool utilizes tree‐ring isotopes (δ18O) combined with a biomechanistic fractionation model to retrodict the δ18O of water utilized during any period of growth. Through comparisons with measured δ18O in local water sources, climatic, and hydrological variables, ISO‐Tool can reconstruct and inform on past ecohydrological interactions. We provide an overview of the modeling components and data requirements necessary to constrain the retrodictions of source‐water δ18O. We demonstrate the utility and efficacy of ISO‐Tool for three riparian field sites characterized by differences in climatic, geomorphic, and hydrologic complexity. We also state that ISO‐Tool can be applied to a range of vegetated environments where distinct isotopic endmembers exist. We present a set of tool groups, which can be applied adaptively, ensuring that scientific progress in understanding retrospective ecohydrology can be made, even under varying degrees of data availability.
Hot and Heterogenous High‐3He/4He Components: New Constraints From Proto‐Iceland Plume Lavas From Baffin Island
Authors: Willhite Lori N. , Jackson Matthew G. , Blichert‐Toft Janne , Bindeman Ilya , Kurz Mark D. , Halldórsson Sæmundur A. , Harðardóttir Sunna , Gazel Esteban , Price Allison A. , Byerly Benjamin L. 
Published: November 2019

AbstractThe Icelandic hotspot has erupted basaltic magma with the highest mantle‐derived 3He/4He over a period spanning much of the Cenozoic, from the early‐Cenozoic Baffin Island‐West Greenland flood basalt province (49.8 RA), to mid‐Miocene lavas in northwest Iceland (40.2 to 47.5 RA), to Pleistocene lavas in Iceland's neovolcanic zone (34.3 RA). The Baffin Island lavas transited through and potentially assimilated variable amounts of Precambrian continental basement. We use geochemical indicators sensitive to continental crust assimilation (Nb/Th, Ce/Pb, MgO) to identify the least crustally contaminated lavas. Four lavas, identified as “least crustally contaminated,” have high MgO (>15 wt.%), and Nb/Th and Ce/Pb that fall within the mantle range (Nb/Th = 15.6 ± 2.6, Ce/Pb = 24.3 ± 4.3). These lavas have 87Sr/86Sr = 0.703008–0.703021, 143Nd/144Nd = 0.513094–0.513128, 176Hf/177Hf = 0.283265–0.283284, 206Pb/204Pb = 17.7560–17.9375, 3He/4He up to 39.9 RA, and mantle‐like δ18O of 5.03–5.21‰. The radiogenic isotopic compositions of the least crustally contaminated lavas are more geochemically depleted than Iceland high‐3He/4He lavas, a shift that cannot be explained by continental crust assimilation in the Baffin suite. Thus, we argue for the presence of two geochemically distinct high‐3He/4He components within the Iceland plume. Additionally, the least crustally contaminated primary melts from Baffin Island‐West Greenland have higher mantle potential temperatures (1510 to 1630 °C) than Siqueiros mid‐ocean ridge basalts (1300 to 1410 °C), which attests to a hot, buoyant plume origin for early Iceland plume lavas. These observations support the contention that the geochemically heterogeneous high‐3He/4He domain is dense, located in the deep mantle, and sampled by only the hottest plumes.
Storm Time Depletions of Multi‐MeV Radiation Belt Electrons Observed at Different Pitch Angles
Authors: Drozdov A. Y. , Aseev N. , Effenberger F. , Turner D. L. , Saikin A. , Shprits Y. Y. 
Published: November 2019

AbstractDuring geomagnetic storms, the rapid depletion of the high‐energy (several MeV) outer radiation belt electrons is the result of loss to the interplanetary medium through the magnetopause, outward radial diffusion, and loss to the atmosphere due to wave‐particle interactions. We have performed a statistical study of 110 storms using pitch angle resolved electron flux measurements from the Van Allen Probes mission and found that inside of the radiation belt (L* = 3 − 5) the number of storms that result in depletion of electrons with equatorial pitch angle αeq = 30∘ is higher than number of storms that result in depletion of electrons with equatorial pitch angle αeq = 75∘. We conclude that this result is consistent with electron scattering by whistler and electromagnetic ion cyclotron waves. At the outer edge of the radiation belt (L* ≥ 5.2) the number of storms that result in depletion is also large (~40–50%), emphasizing the significance of the magnetopause shadowing effect and outward radial transport.
Coastal Inundation Mapping From Bitemporal and Dual‐Polarization SAR Imagery Based on Deep Convolutional Neural Networks
Authors: Liu Bin , Li Xiaofeng , Zheng Gang 
Published: November 2019

AbstractThis study develops an effective and robust method to mine bitemporal and dual‐polarization synthetic aperture radar (SAR) imagery information for coastal inundation mapping, based on deep convolutional neural networks. The specially tailored deep convolutional neural network‐based SAR coastal flooding mapping network (SARCFMNet) leverages two modifications to improve the accuracy and robustness: the physics‐aware input information design and the regularization. The proposed SARCFMNet is applied to the mapping and impact analysis of the coastal inundation caused by 2017 Hurricane Harvey near Houston, Texas, USA. Six pairs of Sentinel‐1 SAR images are analyzed along with corresponding ground truth data from Copernicus Emergency Management Service Rapid Mapping products and land‐cover types from Google Earth and OpenStreetMap. Flooded areas of 4,000 km2 are extracted and analyzed. In an analyzed scene, 76% of the flooded area was agriculture area like pasture and cultivated crops field. A flooding map series shows the inundation shrinking rate is about 1% of the analyzed scene per day after the passage of Harvey. However, there was a delayed inundation in Glen Flora, Texas, after the heavy raining period. The average mapping accuracy and F1 score, that is, the harmonic mean of recall and precision, are 0.98 and 0.88, respectively. The impact of wind and cost‐sensitive loss functions on the development of SARCFMNet is also discussed. This study demonstrates the proposed method can accurately map hurricane‐induced inundation. The method can also be readily extended to other multitemporal SAR imagery classification applications.
Ventilation of the Deep Ocean Carbon Reservoir During the Last Deglaciation: Results From the Southeast Pacific
Authors: Martínez Fontaine Consuelo , De Pol‐Holz Ricardo , Michel Elisabeth , Siani Giuseppe , Reyes‐Macaya Dharma , Martínez‐Méndez Gema , DeVries Tim , Stott Lowell , Southon John , Mohtadi Mahyar , Hebbeln Dierk 
Published: November 2019

AbstractCoeval changes in atmospheric CO2 and 14C contents during the last deglaciation are often attributed to ocean circulation changes that released carbon stored in the deep ocean during the Last Glacial Maximum (LGM). Work is being done to generate records that allow for the identification of the exact mechanisms leading to the accumulation and release of carbon from the oceanic reservoir, but these mechanisms are still the subject of debate. Here we present foraminifera 14C data from five cores in a transect across the Chilean continental margin between ~540 and ~3,100 m depth spanning the last 20,000 years. Our data reveal that during the LGM, waters at ~2,000 m were 50% to 80% more depleted in Δ14C than waters at ~1,500 m when compared to modern values, consistent with the hypothesis of a glacial deep ocean carbon reservoir that was isolated from the atmosphere. During the deglaciation, our intermediate water records reveal homogenization in the Δ14C values between ~800 and ~1,500 m from ~16.5–14.5 ka cal BP to ~14–12 ka cal BP, which we interpret as deeper penetration of Antarctic Intermediate Water. While many questions still remain, this process could aid the ventilation of the deep ocean at the beginning of the deglaciation, contributing to the observed ~40 ppm rise in atmospheric pCO2.
The Influence of Structural Inheritance and Multiphase Extension on Rift Development, the NorthernNorth Sea
Authors: Phillips Thomas B. , Fazlikhani Hamed , Gawthorpe Rob L. , Fossen Haakon , Jackson Christopher A.‐L. , Bell Rebecca E. , Faleide Jan I. , Rotevatn Atle 
Published: November 2019

AbstractThe northern North Sea rift evolved through multiple rift phases within a highly heterogeneous crystalline basement. The geometry and evolution of syn‐rift depocenters during this multiphase evolution and the mechanisms and extent to which they were influenced by preexisting structural heterogeneities remain elusive, particularly at the regional scale. Using an extensive database of borehole‐constrained 2D seismic reflection data, we examine how the physiography of the northern North Sea rift evolved throughout late Permian‐Early Triassic (RP1) and Late Jurassic‐Early Cretaceous (RP2) rift phases, and assess the influence of basement structures related to the Caledonian orogeny and subsequent Devonian extension. During RP1, the location of major depocenters, the Stord and East Shetland basins, was controlled by favorably oriented Devonian shear zones. RP2 shows a diminished influence from structural heterogeneities, activity localizes along the Viking‐Sogn graben system and the East Shetland Basin, with negligible activity in the Stord Basin and Horda Platform. The Utsira High and the Devonian Lomre Shear Zone form the eastern barrier to rift activity during RP2. Toward the end of RP2, rift activity migrated northward as extension related to opening of the proto‐North Atlantic becomes the dominant regional stress as rift activity in the northern North Sea decreases. Through documenting the evolving syn‐rift depocenters of the northern North Sea rift, we show how structural heterogeneities and prior rift phases influence regional rift physiography and kinematics, controlling the segmentation of depocenters, as well as the locations, styles, and magnitude of fault activity and reactivation during subsequent events.
Future Risks of Tsunami‐Induced Seawater Intrusion Into Unconfined Coastal Aquifers: Insights From Numerical Simulations at Niijima Island, Japan
Authors: Liu Jiaqi , Tokunaga Tomochika 
Published: November 2019

AbstractTsunami‐induced seawater inundation causes vertical seawater infiltration into coastal aquifers and induces unexpected salinization of fresh groundwater resources. Assessing future risks of seawater intrusion in tsunami‐prone areas can provide essential information supporting disaster preparedness. In this study, we investigated seawater intrusion and aquifer recovery processes under the future Nankai earthquake and tsunami scenarios at Niijima Island, Japan. A groundwater model with a 2‐D vertical cross section was developed to solve variable‐density flow and salt transport in unsaturated‐saturated media using the numerical code, FEFLOW. Our simulation results indicate that the unsaturated zone behaves as an initial storage of the infiltrated seawater and controls the maximum amount of seawater infiltration during the anticipated tsunami inundation. The bedrock structures affect the direction of seawater movement in the saturated zone and the flushing time of the polluted aquifer. Our analysis suggests that the tsunami inundation height, the rainfall recharge rate, and hydraulic conductivity are the primary sources of uncertainties in the simulation results. These findings have implications for other tsunami‐prone zones with respect to the understanding of the relevant physical processes and model uncertainties.
Breathing life into engineered tissues using oxygen-releasing biomaterials
Authors: Suvarnapathaki Sanika , Wu Xinchen , Lantigua Darlin , Nguyen Michelle A. , Camci-Unal Gulden 
Published: November 2019

AbstractEngineering three-dimensional (3D) tissues in clinically relevant sizes have demonstrated to be an effective solution to bridge the gap between organ demand and the dearth of compatible organ donors. A major challenge to the clinical translation of tissue-engineered constructs is the lack of vasculature to support an adequate supply of oxygen and nutrients post-implantation. Previous efforts to improve the vascularization of engineered tissues have not been commensurate to meeting the oxygen demands of implanted constructs during the process of homogeneous integration with the host. Maintaining cell viability and metabolic activity during this period is imperative to the survival and functionality of the engineered tissues. As a corollary, there has been a shift in the scientific impetus beyond improving vascularization. Strategies to engineer biomaterials that encapsulate cells and provide the sustained release of oxygen over time are now being explored. This review summarizes different types of oxygen-releasing biomaterials, strategies for their fabrication, and approaches to meet the oxygen requirements in various tissue engineering applications, including cardiac, skin, bone, cartilage, pancreas, and muscle regeneration.
Topological control of extreme waves
Authors: Marcucci Giulia , Pierangeli Davide , Agranat Aharon J. , Lee Ray-Kuang , DelRe Eugenio , Conti Claudio 
Published: November 2019

AbstractFrom optics to hydrodynamics, shock and rogue waves are widespread. Although they appear as distinct phenomena, transitions between extreme waves are allowed. However, these have never been experimentally observed because control strategies are still missing. We introduce the new concept of topological control based on the one-to-one correspondence between the number of wave packet oscillating phases and the genus of toroidal surfaces associated with the nonlinear Schrödinger equation solutions through Riemann theta functions. We demonstrate the concept experimentally by reporting observations of supervised transitions between waves with different genera. Considering the box problem in a focusing photorefractive medium, we tailor the time-dependent nonlinearity and dispersion to explore each region in the state diagram of the nonlinear wave propagation. Our result is the first realization of topological control of nonlinear waves. This new technique casts light on shock and rogue waves generation and can be extended to other nonlinear phenomena.
Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control
Authors: Barrenas Fredrik , Raehtz Kevin , Xu Cuiling , Law Lynn , Green Richard R. , Silvestri Guido , Bosinger Steven E. , Nishida Andrew , Li Qingsheng , Lu Wuxun , Zhang Jianshui , Thomas Matthew J. , Chang Jean , Smith Elise , Weiss Jeffrey M. , Dawoud Reem A. , Richter George H. , Trichel Anita , Ma Dongzhu , Peng Xinxia , Komorowski Jan , Apetrei Cristian , Pandrea Ivona , Gale Michael 
Published: November 2019

AbstractNatural hosts of simian immunodeficiency virus (SIV) avoid AIDS despite lifelong infection. Here, we examined how this outcome is achieved by comparing a natural SIV host, African green monkey (AGM) to an AIDS susceptible species, rhesus macaque (RM). To asses gene expression profiles from acutely SIV infected AGMs and RMs, we developed a systems biology approach termed Conserved Gene Signature Analysis (CGSA), which compared RNA sequencing data from rectal AGM and RM tissues to various other species. We found that AGMs rapidly activate, and then maintain, evolutionarily conserved regenerative wound healing mechanisms in mucosal tissue. The wound healing protein fibronectin shows distinct tissue distribution and abundance kinetics in AGMs. Furthermore, AGM monocytes exhibit an embryonic development and repair/regeneration signature featuring TGF-β and concomitant reduced expression of inflammatory genes compared to RMs. This regenerative wound healing process likely preserves mucosal integrity and prevents inflammatory insults that underlie immune exhaustion in RMs.