bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of CYP2B6 polymorphisms on plasma nevirapine concentrations: a systematic review and meta-analysis
Authors: Yoon Ha Young , Cho Young Ah , Yee Jeong , Gwak Hye Sun 
Published: October 2020

AbstractCytochrome P450 (CYP) is involved in the metabolism of nevirapine (NVP); especially, CYP2B6 has been known to be one of the main enzymes involved in NVP metabolism. The objective of this study was to investigate the effects of CYP2B6 variants on plasma concentrations of NVP by a systematic review and meta-analysis. A search for qualifying studies published until April 2020 was conducted using the EMBASE, PubMed, and Web of Science databases. The mean difference (MD) and 95% confidence intervals (CIs) were calculated. Data analysis was performed using R Studio (version 3.6) and Review Manager (version 5.3). In total, data from six studies involving 634 patients were analyzed in the systematic review and five studies in the meta-analysis. We found that carriers of the CYP2B6 516TT genotype had a 2.18 µg/mL higher NVP concentration than did the GG or GT (95% CI 1.28–3.08). In the respective comparisons of the three genotypes, it was found that the MD was 1.87 µg/mL between the TT and GT groups, 2.53 µg/mL between TT and GG, and 0.60 µg/mL between GT and GG. This meta-analysis confirmed that CYP2B6 polymorphisms was associated with plasma NVP concentrations. Therefore, CYP2B6 genotyping may be useful to predict the responses to NVP.
The role of prognostic nutritional index for clinical outcomes of gastric cancer after total gastrectomy
Authors: Xishan Zhu , Ye Zhao , Feiyan Ma , Liang Xuan , Shikai Wu 
Published: October 2020

AbstractThe purpose of this article is to evaluate the relationship between the nutrition-based microenvironment and clinicopathological information for gastric cancer patients and to investigate the prognostic value of nutrition index for gastric cancer patients undergoing total gastrectomy. We retrospectively collected clinical information of 245 gastric cancer patients who underwent total gastrectomy in our hospital between January 1st 2005 and December 30th 2015. According to the prognostic nutritional index (PNI) level, they were divided into low PNI (< 43) group and high PNI (≥ 43) group. The relationship between PNI and the disease-free survival (DFS) and overall survival (OS) were analyzed by statistical analysis. Univariate analyses demonstrated that TNM stage (p = 0.025), patients age (p = 0.042), lymph node metastasis (p = 0.028), tumor differentiation (p = 0.037) and a low PNI (p = 0.033) were closely correlated with a poor prognosis. In multivariate analysis, TNM stage (p = 0.027) and a low PNI (p = 0.041) were found to be independently associated with poor survival. Additionally, when age was considered as a stratified factor, univariate analyses demonstrated that low PNI correlated with shorter DFS in non-elderly (< 65) patients (p = 0.022) and shorter DFS (p = 0.036) and OS (p = 0.047) in elderly (≥ 65) patients. The low prognostic nutritional index is an independent risk factor associated with poor gastric cancer survival which represents the nutritional microenvironment. Patients with low pre-operative prognostic nutritional index levels should be observed more closely after surgery to prevent the occurrence of post-operative complications in the near future.
Middle identification for rhesus monkeys is influenced by number but not extent
Authors: Rugani Rosa , Platt Michael L. , Chen Zhaoying , Brannon Elizabeth M. 
Published: October 2020

AbstractAbstract concept learning provides a fundamental building block for many cognitive functions in humans. Here we address whether rhesus monkeys (Macaca mulatta) can learn the abstract concept of “middle” in a series of objects. First, we trained monkeys to select the middle dot in a horizontal series of three dots presented on a touchscreen. Monkeys maintained a preference to choose the middle dot despite changes in the appearance, location, and spacing of the horizontal series of dots. They maintained high performance when the color, shape and the length of the stimuli were new, indicating that their responses did not depend upon the particular appearance of the array items. Next, we asked whether monkeys would generalize the middle concept to a 7 dot series. Although accuracy decreased when the number of dots was increased, monkeys continued to preferentially select the middle dot. Our results demonstrate that rhesus macaques can learn to use a middle concept for a discrete set of items.
Brain substrates explain differences in the adoption and degree of financial digitalization
Authors: Carbo-Valverde Santiago , Lacomba-Arias Juan A. , Lagos-García Francisco M. , Rodriguez-Fernandez Francisco , Verdejo-Román Juan 
Published: October 2020

AbstractThis study analyzes neural responses connected to trust and risk to explain financial digitalization decisions. It shows that brain responses distinctively inform differences in the adoption of digital financial channels that are not shown by any other sociodemographic or behavioral indicators. From a methodological standpoint, the study explores if usage patterns of digital financial channels and instruments are associated with psychological and biological indicators; it uses functional magnetic resonance imaging (fMRI) to investigate whether financial digitalization decisions are linked to the evoked brain response to the safety associated with video images of financial transactions through digitalized and non-digitalized channels; it conducts trust and risk neuro-experiments to identify their impact on financial digitalization decisions and it analyzes whether brain structure is linked to financial digitalization behavior. The findings suggest that high and low frequency users exhibit differences in brain function and also in volume and fractional anisotropy values. A higher frequency of use of financial digital financial services is associated with higher brain activation linked to insecurity (lower safety neural evoked responses during the video task and an altered white matter microstructure of the cingulum). Additionally, high frequency users of digital financial channels exhibit enhanced activation of brain areas linked to emotional processing during the trust game. These findings have important implications for the design of public policies to enhance financial inclusion through technology and the segmentation and service distribution strategies of private financial institutions.
ScatLay: utilizing transcriptome-wide noise for identifying and visualizing differentially expressed genes
Authors: Bui Thuy Tien , Lee Daniel , Selvarajoo Kumar 
Published: October 2020

AbstractDifferential expressed (DE) genes analysis is valuable for understanding comparative transcriptomics between cells, conditions or time evolution. However, the predominant way of identifying DE genes is to use arbitrary threshold fold or expression changes as cutoff. Here, we developed a more objective method, Scatter Overlay or ScatLay, to extract and graphically visualize DE genes across any two samples by utilizing their pair-wise scatter or transcriptome-wide noise, while factoring replicate variabilities. We tested ScatLay for 3 cell types: between time points forEscherichia coliaerobiosis andSaccharomyces cerevisiaehypoxia, and between untreated and Etomoxir treatedMus Musculusembryonic stem cell. As a result, we obtain 1194, 2061 and 2932 DE genes, respectively. Next, we compared these data with two widely used current approaches (DESeq2 and NOISeq) with typical twofold expression changes threshold, and show that ScatLay reveals significantly larger number of DE genes. Hence, our method provides a wider coverage of DE genes, and will likely pave way for finding more novel regulatory genes in future works.
Predictive limitations of spatial interaction models: a non-Gaussian analysis
Authors: Hilton B. , Sood A. P. , Evans T. S. 
Published: October 2020

AbstractWe present a method to compare spatial interaction models against data based on well known statistical measures that are appropriate for such models and data. We illustrate our approach using a widely used example: commuting data, specifically from the US Census 2000. We find that the radiation model performs significantly worse than an appropriately chosen simple gravity model. Various conclusions are made regarding the development and use of spatial interaction models, including: that spatial interaction models fit badly to data in an absolute sense, that therefore the risk of over-fitting is small and adding additional fitted parameters improves the predictive power of models, and that appropriate choices of input data can improve model fit.
Central aortic pressure and long-term outcome in hypertensive patients undergoing percutaneous coronary intervention
Authors: Wu Han-Ping , Lin Mao-Jen 
Published: October 2020

AbstractElevated central pulse pressure (CPP) had a negative influence on long-term outcome in patients with hypertension (HT). However, little is known about the impact of central pulse pressure on long-term outcomes in hypertensive patients undergoing PCI. A total number of 1184 hypertensive patients who received PCI procedure were prospectively collected. They were divided into two groups according to the median of central pulse pressure. Baseline characteristics, risk factors, hemodynamic data including central systolic pressure (CSP), central diastolic pressure (CDP) and CPP were measured. Invasive strategies were also analyzed to compare the long term outcome between patients with reference CPP and patients with high CPP. We further analyzed the predictors for myocardial infarction (MI), mortality, repeated PCI procedure in hypertensive patients undergoing PCI. We found patients in the reference CPP group had a lower CSP and higher CDP compared with high CPP group (Both P < 0.001) and male preponderance (P < 0.001). Patients with diabetes and chronic kidney disease (CKD) tend to have a high CPP (both P < 0.001). Drugs including Angiotensin Converting Enzyme inhibitors (ACEI) and statin were used more frequently in patients with reference CPP group (P = 0.035 and P = 0.001, respectively). Freedom from all-cause mortality and cardiovascular(CV) mortality was lower in the patients with high CPP group (P = 0.001, P = 0.01, respectively).Logistic regression revealed that CPP is a major predictor for all-cause mortality and repeated PCI procedure [hazard ratio (HR): 2.46 and 1.41, respectively]. In hypertensive patients receiving PCI, elevated CPP had a negative impact on long-term mortality; CPP also strongly predicts all-cause mortality and repeated PCI procedures in hypertensive patients undergoing PCI.
Combination of rAd-p53 in situ gene therapy and anti-PD-1 antibody immunotherapy induced anti-tumor activity in mouse syngeneic urogenital cancer models
Authors: Kunimura Naoto , Kitagawa Koichi , Sako Ryota , Narikiyo Keita , Tominaga Shoko , Bautista Diosdado S. , Xu Wei , Fujisawa Masato , Shirakawa Toshiro 
Published: October 2020

AbstractIn this study we undertook a novel combination therapy using rAd-p53 in situ gene therapy and immunotherapy with immune checkpoint inhibitor (ICI) anti-PD-1 antibody for urogenital cancers. Three mouse syngeneic tumor cell lines, TRAMP-C2 (prostate cancer derived from C57BL/6 mice), MBT-2 (bladder cancer derived from C3H mice) and Renca (kidney cancer derived from BALB/c mice) were used in this study. The highest coxsackie and adenovirus receptor (CAR) mRNA expression was observed in TRAMP-C2 cells, followed by Renca and then MBT-2 cells. Consistent with the CAR expressions, rAd-p53 at 160 multiplicity of infection (MOI) significantly inhibited the cell proliferation of TRAMP-C2 and Renca cells, but not MBT-2 cells. In in vivo experiments, the combination of intratumoral injections of rAd-p53 (1 × 109 plaque-forming units) every other day and intraperitoneal injections of anti-mouse PD-1 antibody (200 μg) twice a week suppressed tumor growth and prolonged survival compared to rAd-p53 or anti-PD-1 antibody monotherapy in both the TRAMP-C2 and Renca models. Our results encourage the clinical development of combination therapy comprised of in situ gene therapy with rAd-p53 and immunotherapy with an ICI anti-PD-1 antibody for urogenital cancers.
Redundant type II cadherins define neuroepithelial cell states for cytoarchitectonic robustness
Authors: Hiraga Kou , Inoue Yukiko U. , Asami Junko , Hotta Mayuko , Morimoto Yuki , Tatsumoto Shoji , Hoshino Mikio , Go Yasuhiro , Inoue Takayoshi 
Published: October 2020

AbstractIndividual cell shape and integrity must precisely be orchestrated during morphogenesis. Here, we determine function of type II cadherins, Cdh6, Cdh8, and Cdh11, whose expression combinatorially demarcates the mouse neural plate/tube. While CRISPR/Cas9-based single type II cadherin mutants show no obvious phenotype, Cdh6/8 double knockout (DKO) mice develop intermingled forebrain/midbrain compartments as these two cadherins’ expression opposes at the nascent boundary. Cdh6/8/11 triple, Cdh6/8 or Cdh8/11 DKO mice further cause exencephaly just within the cranial region where mutated cadherins’ expression merges. In the Cdh8/11 DKO midbrain, we observe less-constricted apical actin meshwork, ventrally-directed spreading, and occasional hyperproliferation among dorsal neuroepithelial cells as origins for exencephaly. These results provide rigid evidence that, by conferring distinct adhesive codes to each cell, redundant type II cadherins serve essential and shared roles in compartmentalization and neurulation, both of which proceed under the robust control of the number, positioning, constriction, and fluidity of neuroepithelial cells.
Urinary phosphate-containing nanoparticle contributes to inflammation and kidney injury in a salt-sensitive hypertension rat model
Authors: Wang Qin , Ishizawa Kenichi , Li Jinping , Fujii Wataru , Nemoto Yoshikazu , Yamazaki Osamu , Tamura Yoshifuru , Miura Yutaka , Nie Xuedan , Abe Ryo , Segawa Hiroko , Kuro-O Makoto , Shibata Shigeru 
Published: October 2020

AbstractAlthough disturbed phosphate metabolism frequently accompanies chronic kidney disease (CKD), its causal role in CKD progression remains unclear. It is also not fully understood how excess salt induces organ damage. We here show that urinary phosphate-containing nanoparticles promote kidney injury in salt-sensitive hypertension. In Dahl salt-sensitive rats, salt loading resulted in a significant increase in urinary phosphate excretion without altering serum phosphate levels. An intestinal phosphate binder sucroferric oxyhydroxide attenuated renal inflammation and proteinuria in this model, along with the suppression of phosphaturia. Using cultured proximal tubule cells, we confirmed direct pathogenic roles of phosphate-containing nanoparticles in renal tubules. Finally, transcriptome analysis revealed a potential role of complement C1q in renal inflammation associated with altered phosphate metabolism. These data demonstrate that increased phosphate excretion promotes renal inflammation in salt-sensitive hypertension and suggest a role of disturbed phosphate metabolism in the pathophysiology of hypertensive kidney disease and high salt-induced kidney injury.
Transversally travelling ultrasound for light guiding deep into scattering media
Authors: Cherkashin Maxim N. , Brenner Carsten , Schmitz Georg , Hofmann Martin R. 
Published: October 2020

AbstractThe application of optical methods for tissue diagnosis, activation, and treatment suffers dramatically from the low accessible depths due to strong light scattering in tissues. Here we demonstrate a method to address this issue by utilizing transient ultrasound waves, travelling transversally to the light propagation direction, to guide light into deeper tissue regions. We study the formation of the ultrasound-induced refractive index structures and waveguides using simple ultrasound field configurations and analyze their effects on the propagation of short light pulses. As a proof of concept, we demonstrate using 5 ns pulses of 532 nm light and Intralipid-20%-based phantoms with$$\mu _{\mathrm{s}}^\prime$$μs′up to 4.5 cm−1a waveguide supported light intensity increase up to the depths of at least 90 mean free paths.
Successful ecosystem-based management of Antarctic krill should address uncertainties in krill recruitment, behaviour and ecological adaptation
Authors: Meyer Bettina , Atkinson Angus , Bernard Kim S. , Brierley Andrew S. , Driscoll Ryan , Hill Simeon L. , Marschoff Enrique , Maschette Dale , Perry Frances A. , Reiss Christian S. , Rombolá Emilce , Tarling Geraint A. , Thorpe Sally E. , Trathan Philip N. , Zhu Guoping , Kawaguchi So 
Published: October 2020

AbstractAntarctic krill, Euphausia superba, supports a valuable commercial fishery in the Southwest Atlantic, which holds the highest krill densities and is warming rapidly. The krill catch is increasing, is concentrated in a small area, and has shifted seasonally from summer to autumn/winter. The fishery is managed by the Commission for the Conservation of Antarctic Marine Living Resources, with the main goal of safeguarding the large populations of krill-dependent predators. Here we show that, because of the restricted distribution of successfully spawning krill and high inter-annual variability in their biomass, the risk of direct fishery impacts on the krill stock itself might be higher than previously thought. We show how management benefits could be achieved by incorporating uncertainty surrounding key aspects of krill ecology into management decisions, and how knowledge can be improved in these key areas. This improved information may be supplied, in part, by the fishery itself.
Significant contribution of small icebergs to the freshwater budget in Greenland fjords
Authors: Rezvanbehbahani Soroush , Stearns Leigh A. , Keramati Ramtin , Shankar Siddharth , van der Veen C. J. 
Published: October 2020

AbstractIcebergs represent nearly half of the mass loss from the Greenland Ice Sheet and provide a distributed source of freshwater along fjords which can alter fjord circulation, nutrient levels, and ultimately the Meridional Overturning Circulation. Here we present analyses of high resolution optical satellite imagery using convolutional neural networks to accurately delineate iceberg edges in two East Greenland fjords. We find that a significant portion of icebergs in fjords are comprised of small icebergs that were not detected in previously-available coarser resolution satellite images. We show that the preponderance of small icebergs results in high freshwater delivery, as well as a short life span of icebergs in fjords. We conclude that an inability to identify small icebergs leads to inaccurate frequency-size distribution of icebergs in Greenland fjords, an underestimation of iceberg area (specifically for small icebergs), and an overestimation of iceberg life span.
Effective electrocatalytic methanol oxidation of Pd-based metallic glass nanofilms
Authors: Sarac Baran , Karazehir Tolga , Ivanov Yurii P. , Putz Barbara , Greer A. Lindsay , Sarac A. Sezai , Eckert Jürgen 
Published: October 2020

Compared to conventional polycrystalline Pd, Pd79Au9Si12 metallic glass nanofilm electrocatalyst offers better methanol oxidation in alkaline medium, CO poisoning tolerance and catalyst stability even at high scan rates or high methanol concentrations.
Ultrasonic irradiation and SonoVue microbubbles-mediated RNA interference targeting PRR11 inhibits breast cancer cells proliferation and metastasis, but promotes apoptosis
Authors: Luo Hui , Li Jian , Lin Qi , Xiao Xiaojun , Shi Yang , Ye Xiuqin , Wei Zhanghong , Liu Yingying , Xu Jinfeng 
Published: October 2020

Abstract
The present study compared the effects of ultrasonic irradiation and SonoVue microbubbles (US) or Lipofectamine 3000 on the transfection of small interfering RNA for PRR11 (siPRR11) and Proline-rich protein 11 (PRR11) overexpression plasmid into breast cancer cells. SiPRR11 and PRR11 overexpression plasmid were transfected into breast cancer MCF7 cells mediated by US and Lipofectamine 3000. PRR11 expressions in breast cancer and normal tissues were determined using Gene Expression Profiling Interactive Analysis (GEPIA). The viability, proliferation, migration, invasion and apoptosis of breast cancer cells were respectively measured by MTT assay, clone formation assay, scratch wound-healing assay, Transwell assay and flow cytometry. PRR11 and epithelial-to-mesenchymal transition (EMT)-related and apoptosis-related (B-cell lymphoma 2, Bcl-2; Bcl-2-associated protein X, Bax) proteins’ expressions were detected by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot as appropriate. As ultrasonic intensity increased, the viability of MCF7 cells was decreased. Results from GEPIA suggested that PRR11 was up-regulated in breast cancer. Silencing PRR11 mediated by US showed a higher efficiency than by Lipofectamine 3000. SiPRR11 transfected by Lipofectamine 3000 suppressed cells growth and metastasis, while promoted cell apoptosis. Moreover, E-cadherin (E-cad) and Bax expressions were high but N-cadherin (N-cad), Snail and Bcl-2 expressions were low. However, overexpressed PRR11 caused the opposite effects. More importantly, transfection of siPRR11 and PRR11 overexpression plasmid using US had a higher efficacy than using Lipofectamine 3000. US transfection of PRR11 siRNA showed better effects on inhibiting breast cancer progression. The current findings contribute to a novel treatment for breast cancer.
Zeta-regularization of arithmetic sequences
Authors: Allouche Jean-Paul 
Published: October 2020

Is it possible to give a reasonable value to the infinite product 1 × 2 × 3 × · · · × n × · · · ? In other words, can we define some sort of convergence of the finite product 1 × 2 × 3 × · · · × n when n goes to infinity? One way is to relate this product to the R√iemann zeta function and to its analytic continuation. This approach leads to: 1 × 2 × 3 × · · · × n × · · · =	2π. More generally the “zeta-regularization” of an infinite product consists of introducing a related Dirichlet series and its analytic continuation at 0 (if it exists). We will survey some properties of this generalized product and allude to applications. Then we will give two families of possibly new examples: one unifies and generalizes known results for the zeta-regularization of the products of Fibonacci, balanced and Lucas-balanced numbers; the other studies the zeta-regularized products of values of classical arithmetic functions. Finally we ask for a possible zeta-regularity notion of complexity.
Synthesis of the 26-Membered Core of Thiopeptide Natural Products by Scalable Thiazole-Forming Reactions of Cysteine Derivatives and Nitriles
Authors: Siegel Dionicio , Johnson Trevor C. , Christy Mitchell P. 
Published: October 2020

AbstractThe increased resistance of bacteria to clinical antibiotics is one of the major dilemmas facing human health and without solutions the problem will grow exponentially worse. Thiopeptide natural products have shown promising antibiotic activities and provide an opportunity for the development of a new class of antibiotics. Attempts to directly translate these compounds into human medicine have been limited due to poor physiochemical properties. The synthesis of the core structure of the 26-membered class of thiopeptide natural products is reported using chemistry that enables the synthesis of large quantities of synthetic intermediates and the common core structure. The use of cysteine/nitrile condensation reactions followed by oxidation to generate thiazoles has been key in enabling large academic scale reactions that in many instances avoided chromatography further aiding in accessing large amounts of key synthetic intermediates.