bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of treatment on quality of life in patients with acromegaly: a prospective study
Authors: Wolters T L C , Roerink S H P P , Sterenborg R B T M , Wagenmakers M A E M , Husson O , Smit J W A , Hermus A R M M , Netea-Maier R T 
Published: January 2020

Objective
Acromegaly has a negative influence on health-related quality of life (HRQoL). Previous studies provide limited information on the course of HRQoL during treatment. This study aims to assess the effect of treatment on the course of HRQoL at six predefined time points.

Design
This prospective study examines HRQoL in treatment-naive patients before and during the first 2.5 years of acromegaly treatment.

Methods
Therapy-naive acromegaly patients completed three validated questionnaires (RAND-36, AcroQoL, and the Appearance Self-Esteem (ASE)) at six predetermined time points before, during, and after treatment. Outcomes were correlated to IGF1 levels and disease control status.

Results
Twenty-seven acromegaly patients completed the questionnaires at all time points. After treatment, all patients had controlled acromegaly. Scores of RAND-36 domains General health, Vitality and Health change, and all AcroQoL dimensions (except for Relations) improved during treatment (P ≤ 0.003); the largest changes were detected during the first year. Gender influenced HRQoL scores, since AcroQoL scores significantly improved in males but not in females. Over time, IGF1 levels were negatively correlated with HRQoL. After 2.5 years of follow-up, HRQoL of controlled patients was still lower than in the general population.

Conclusion
HRQoL of acromegaly patients was considerably reduced at diagnosis. Disease control was associated with an improvement of HRQoL scores. Males showed a more pronounced improvement than females. The largest changes were detected in the first year of treatment. However, HRQoL during and after treatment remained impaired in acromegaly patients, emphasizing the need of additional support.
Increase of orexin A in the peripheral blood of adolescents with Internet gaming disorder
Authors: Choi Mi Ran , Cho Hyun , Chun Ji-Won , Yoo Jae Hyun , Kim Dai-Jin 
Published: January 2020

Background and aims
Overindulgence in Internet gaming, which is related to rapid development of the online game industry, can cause a psychiatric disorder known as Internet gaming disorder (IGD). The number of adolescents with IGD is on the rise in countries with developed Internet technologies, such as South Korea. Therefore, it is important to develop biomarkers to detect patients at high risk of IGD. This study investigated expression levels of proteins in the blood of adolescents to provide insight into the development of biomarkers.

Methods
We collected blood samples from 73 subjects [40 healthy adolescents (Internet gaming control, IGC) and 33 adolescents with IGD] between 13:00 and 15:00. We analyzed the expression levels of orexin A, oxytocin, cortisol, melatonin, BDNF, sICAM-1, RANTES, and NCAM using multiplex assay kits.

Results
Orexin A was significantly (p = .016) elevated in the IGD group and the expression levels of melatonin tended to be higher (p = .055) in the IGD group. On the other hand, increased Internet gaming time in the IGD group was negatively correlated (p = .041) with expression of BDNF. On the contrary, sICAM-1 associated with inflammation exhibited the tendency of the positive correlation (p = .073) with Internet gaming time in the IGD group.

Discussion and conclusions
We identified elevation of orexin A in the peripheral blood of adolescents with IGD and a negative correlation between Internet gaming time and BDNF in adolescents with IGD. Our results provide useful information to understand the pathophysiology of IGD in adolescents.
The 2^k Neighborhoods for Grid Path Planning
Authors: Rivera Nicolás , Hernández Carlos , Hormazábal Nicolás , Baier Jorge A 
Published: January 2020

Grid path planning is an important problem in AI. Its understanding has been key for the development of autonomous navigation systems. An interesting and rather surprising fact about the vast literature on this problem is that only a few neighborhoods have been used when evaluating these algorithms. Indeed, only the 4- and 8-neighborhoods are usually considered, and rarely the 16-neighborhood. This paper describes three contributions that enable the construction of effective grid path planners for extended 2k-neighborhoods; that is, neighborhoods that admit 2k neighbors per state, where k is a parameter. First, we provide a simple recursive definition of the 2k-neighborhood in terms of the 2k-1-neighborhood. Second, we derive distance functions, for any k ≥ 2, which allow us to propose admissible heuristics that are perfect for obstacle-free grids, which generalize the well-known Manhattan and Octile distances. Third, we define the notion of canonical path for the 2k-neighborhood; this allows us to incorporate our neighborhoods into two versions of A*, namely Canonical A* and Jump Point Search (JPS), whose performance, we show, scales well when increasing k. Our empirical evaluation shows that, when increasing k, the cost of the solution found improves substantially. Used with the 2k-neighborhood, Canonical A* and JPS, in many configurations, are also superior to the any-angle path planner Theta* both in terms of solution quality and runtime. Our planner is competitive with one implementation of the any-angle path planner, ANYA in some configurations. Our main practical conclusion is that standard, well-understood grid path planning technology may provide an effective approach to any-angle grid path planning.
O espírito da utopia vive
Authors: Albornoz Suzana 
Published: January 2020

Escrito como homenagem por ocasião do centenário da 1ª edição de O espírito da utopia (1918) de Ernst Bloch (1885-1977), o texto relembra o conteúdo da obra e o significado da utopia na modernidade; e ao fazer referência à Tese 9 sobre a História, de Walter Benjamin(1892-1940), alude aos clamores que, em nossos dias, testemunham a sobrevivência do espírito utópico.
Palavras-chave: Bloch, espírito, utopia, música, história, Benjamin.
Caminhos da imaginação sociológica ou de como me tornei uma socióloga
Authors: Ramos Marília Patta 
Published: January 2020

O presente artigo trata-se de um ensaio, quase biográfico, sobre a trajetória de uma socióloga, em particular de uma profissional que iniciou sua vida profissional no departamento de Ciências Humanas da Universidade de Santa Cruz do Sul. O texto está estruturado em vários itens, mas a rigor segue uma organização cronológica que inicia com a descrição da origem social da autora, a sua escolha pelas Ciências Sociais, a qual a autora argumenta ter profunda relação com sua origem; a formação acadêmica em nível de graduação e pós-graduação, mestrado e doutorado e sua profissionalização desde quando ingressou na UNISC até os dias de hoje, como docente e pesquisadora na UFRGS. Se utilizando de forte influência weberiana e porque não dizer, bourdiesana, a autora conecta suas escolhas profissionais a sua origem social bem como com as opções com as quais se deparou naquele percurso. No artigo a autora reflete sobre o fazer sociológico de uma profissional com perfil pragmático e aplicado bem como traz uma descrição dos temas por ela pesquisados no seu percurso enquanto docente e pesquisadora.
Palavras-chave: Sociologia, escolhas profissionais, fazer sociológico, atuação acadêmica.
Quando a participação popular é inócua: o greenwashing do carvão na região metropolitana de Porto Alegre/RS
Authors: Brose Markus Erwin 
Published: January 2020

O presente ensaio propõe análise crítica dos mecanismos participativos utilizados no processo de licenciamento do Projeto Mina Guaíba, na Região Metropolitana de Porto Alegre. Cobrindo 4.380 hectares trata-se da maior lavra de carvão mineral a céu aberto no país, visando abastecer Polo Carboquímico composto por termelétrica, usina de gaseificação e indústrias de fertilizantes a serem construídos por estatais chinesas. Apresenta a hipótese que a decisão pela construção do polo foi incentivada pelo governo da China que, desde a crise de poluição atmosférica pelas termelétricas a carvão, em 2013, financia a exportação da capacidade ociosa de planejamento e construção de instalações industriais. De modo receptivo, o governo gaúcho criou, em 2017, o programa PROCARVÃO-RS buscando atrair expertise e capital chinês. Com base em referencial metodológico estabelecido por pesquisa pelo IPEA, e utilizando a Escada de Arnstein, conclui que as audiências públicas realizadas na região metropolitana são inócuas quanto aos objetivos da Política Gaúcha sobre Mudanças Climáticas, na medida em que não alteram escopo ou alcance da implantação da lavra, se restringindo a adicionar eventuais medidas compensatórias.
Palavras-chave: Carvão mineral. Poluição atmosférica. Mina Guaíba.
A estrutura de ocupações nos mercados de trabalho das cidades médias no Rio Grande do Sul: uma análise da dinâmica recente
Authors: Cadoná Marco André 
Published: January 2020

O artigo apresenta dados de uma pesquisa realizada com o objetivo de analisar como a dinâmica de desenvolvimento do capitalismo no Brasil, em especial a partir da década de 2010, repercutiu nos mercados de trabalho de cidades médias do Rio Grande do Sul. Tomando como referência as mudanças ocorridas na estrutura de ocupações das cidades médias do Rio Grande do Sul no período entre 2010 e 2017, propõe-se que, apesar das singularidades dos mercados de trabalho das cidades médias gaúchas, algumas tendências gerais estão presentes no período analisado, indicando um processo de aprofundamento da insegurança dos trabalhadores nesses mercados de trabalho. Insegurança essa objetivada, por exemplo, nos altos índices de rotatividade nos empregos, no baixo poder aquisitivo dos salários, na criação de empregos vinculados ao setor de serviços básicos e que não estão associados a exigências de maior qualificação profissional.
Palavras-chave: Trabalho, mercados de trabalho, cidades médias, estrutura de ocupações, insegurança nos empregos.
Adrenal gland as a target of synchronous and metacronous metastasis from renal cell carcinoma: results of surgical treatment in a single institution
Authors: Muradyan A. G. , Kostin A. A. , Vorobyev N. V. , Tolkachev A. O. 
Published: January 2020

Background. Surgical treatment of solitary and oligometastatic metastases in renal cell carcinoma (RCC) is one of the treatment options for modern oncology.The objective of study to compare surgical outcomes in treatment of synchronous and metachronous solitary metastatic adrenal tumors in RCC.Materials and methods. The study included 93 patients with kidney cancer, from 1997 till 2018, who underwent surgical treatment in the urological oncology department of the P.A. Hertzen Moscow Oncology Research Institute. The 1st group is represented by 58 patients with RCC and synchronous secondary adrenal gland lesion, who underwent simultaneous surgery, consist of radical nephrectomy and adrenalectomy without subsequent adjuvant therapy. The 2nd group included 35 patients with metachronous solitary metastatic adrenal gland lesion who underwent surgical treatment.Results. The progression of disease to left adrenal gland was observed in 40 (43.0 %) cases, to the right – in 39 (41.9 %), both adrenal glands — 14 (15.1 %) cases. The median diameter of the adrenal tumors was 44 (4—170) mm, the most common in both groups were tumors less than 5 cm (58.1 %). The sensitivity of ultrasound in the diagnosis of adrenal tumors was 80.6 %, computed tomography – 93.5 %, adrenal biopsy – 73.9 %. The median of the observation time was 42 months (1st group — 24 months, 2nd group – the median was not achieved). The one-year survival of patients with a metachronous lesion of adrenal was 82.3 ± 76.6 % versus 52.8 ± 7.1 % in the synchronous lesion group, three-year survival was 79.2 ± 7.0 % versus 32.3 ± 7.6 % and five-year – 57.0 ± 10.0 % versus 16.2 ± 12.0 %, respectively. In multivariate analysis, only a metachronous lesion is a factor of favorable prognosis (p = 0.002).Conclusion. Surgical treatment for metachronous adrenal gland metastatic lesions is appropriate intervention and provides better patient survival rates compared to synchronous lesions.
Dynamic magnetic-resonance cystography in diagnosis of perivesical fat invasion in bladder cancer
Authors: Grigoriev E. G. , Frolova I. G. , Usynin E. A. , Vasiliev N. V. , Usova A. V. , Trukhacheva N. G. , Velichko S. A. 
Published: January 2020

Objective: to evaluate the diagnostic capabilities of the dynamic magnetic-resonance cystography technique in detecting invasion of perivesical fat in case of bladder cancer.Materials and methods. The study included 125 patients (105 male and 20 females, mean 62.6 Ѓ} 11.0 years) with transitional cell carcinoma of the bladder. To assess the accuracy of the dynamic cystography method, cases with a tumor size of more than 20 mm, affecting the wall outside the bladder triangle, were selected with suspicion of perivesical fat invasion on magnetic-resonance scans. A furacilin solution was fractional injected into the catheterized bladder to obtain repeated series of T2‑haste-FS images until the bladder was completely expanded.Results. In postprocessing, the selection of areas of interest (ROI) was performed along the contour of the affected wall in the cross section through the center of the tumor. Comparison of the displacement of the affected and intact walls by a diagram of the values of the intensity of the magnetic-resonance signal in the dynamics of bladder dilatation was evaluated. The verification method was the morphological study of the surgical material after the operative treatment. The limit of values with a more likely lesion of perivesical fat was found, which is less than 11 % of the intensity change of the magnetic-resonance signal in selected ROIs during bladder wall expansion.Conclusion. The effectiveness of dynamic magnetic-resonance cystography in the differential diagnosis of perivesical fat infiltration in bladder cancer is characterized by a sensitivity of 90.0 %, a specificity of 93.3 %, and an accuracy of 92.0 %. The proposed technique improves the accuracy of the magnetic resonance imaging method with suspected infiltration of perivesical fat and is well tolerated by patients.
IMPLEMENTASI PENGELOLAAN KEUANGAN BADAN USAHA MILIK DESA (STUDI DESA GONDOWANGI KECAMATAN WAGIR KABUPATEN MALANG)
Authors: Rofidah Naily , Rochayatun Sulis 
Published: January 2020

<p><em>Village development is the focus of national development because the village is a sub-section of the national territory that directly </em><em>manage </em><em>the</em><em> society</em><em>. Nowdays villages are required to have BUMDes as a leading organization aimed </em><em>to </em><em>optimiz</em><em>e</em><em> village potential (Wargiyat, 2015). </em><em>The m</em><em>anagement of BUMDes must be in accordance with established regulations;</em><em> </em><em>financial management of BUMDes is guided by Regulation </em><em>o</em><em>f The Minister </em><em>o</em><em>f Village </em><em>(</em><em>Permendes</em><em>)</em><em> Number 4 of 2015 and Ministry of Home Affair regulations </em><em>(</em><em>Permendagri</em><em>)</em><em> 113 of 2015. Principles that must be upheld in the management of BUMDes are cooperative, participatory, emancipatory, transparent, accountable, and sustainable.The purpose of this study </em><em>i</em><em>s to determine the financial management of BUMDes Gondowangi in Gondowangi Village, Wagir District, Malang Regency. Th</em><em>e</em><em> type of </em><em>this </em><em>research is qualitative with a case study approach. </em><em>The conclusions that can be taken are financial management carried out by BUMDes Gondowangi is still simple. The planning is done by holding a meeting of each unit to form the budget plan</em><em> (</em><em>RAB</em><em>)</em><em>. Implementation is carried out using receipts as proof of disbursement of funds. </em><em>However, the a</em><em>dministration is done by recording cash income and expenditure. </em><em>Then, </em><em>Recording </em><em>which is carried out </em><em>is still general. Accountability is carried out by giving a report to the regional consultative committee</em><em> (BPD) of </em><em>Village and Community </em><em>a</em><em>nd Village Empowerment </em><em>a</em><em>nd Service </em><em>(</em><em>DPMD</em><em>) of </em><em>Malang District, as well as sending a soft file to the Ministry of Village, and delivering it to the community together with the village meeting. The accountability of regular activities in 2017 is also carried out by BUMDes Gondowangi in village meetings. Supervision in the form of guidance from the governor and regent / mayor has not been obtained by BUMDes Gondowangi.</em><em></em></p><p> </p>
Resistensi Antibiotik pada Escherichia coli yang Diisolasi dari Daging Ayam pada Pasar Tradisional di Kota Bogor (ANTIBIOTIC RESISTANCE IN ESCHERICHIA COLI ISOLATED FROM CHICKEN MEAT OF TRADITIONAL MARKETS IN THE CITY OF BOGOR)
Authors: Januari Connie , Sudarwanto Mirnawati Bachrum , Purnawarman Trioso 
Published: January 2020

Antibiotic use in farm is spread widely to treat of poultry disease including therapy, supportive or preventive use and as afeed additive to improve chicken performance. The negative effects of antibiotic use can increase the level of bacterial resistance to antibiotics. This study aimed to investigate on antibiotic resistance in Escherichia coli isolated from chicken meat that were sold in Traditional Market of Bogor City. A total of 175 samples of chicken meat were taken by purposive sampling method, out of 175 found 50 positive samples of E. coli. The samples were subjected to E. coli examination and the isolated E. coli were tested for the antibiotic resistance using eight antibiotics, i.e., amoxicillin, cefotaxime, colistin, nalidixid acid, streptomycin, erythromycin, oxytetracillin, and tetracycline. The study was conducted by using the disk diffusion method on Muller-Hinton agar according to the Clinical and Laboratory Standards Institute guidelines. The study showed E. coli isolated from chicken meat were resistance towards amoxicilin (90%), colistin (94%), nalidixid acid (86%), streptomycin (98%), erythromycin (98%), oxytetracillin (84%), tetracycline (86%), and cefotaxime antibiotics (12%). The proportion of multidrugresistant was 99%. The higher of multidrug-resistant indicated the E. coli would be a threat to public and environmental health.
Ekstrak Etanol Kulit Buah Jengkol Menurunkan Kadar Glukosa dan Meningkatkan Hormon Insulin Tikus Diabetes Yang Diinduksi Streptozotocin
Authors: Malini Desak Made , Madihah Madihah , Khoirunnisa Dita Aprila , Sasmita Indriani , Ratningsih Nining , Alipin Kartiawati , Hermawan Wawan 
Published: January 2020

Diabetes Mellitus (DM) is a disease with metabolism disorder signed by increasing of glucose blood (hyperglicemia), caused by disorder of insulin secretion and or increasing of insulin resistance. Therapy of jengkol’s fruit peel is an alternative treatment for DM. This study aims to determine the effect of ethanol extract of jengkol’s fruit peel to decrease glucose and increase insulin level of Wistar female rats which induced by streptozotocin (STZ). This research used the experimental method of Completely Randomized Design (RAL). Rat were first induced by single intravenous injection of STZ except Negative Control. Furthermore, rats were divided into six groups, namely Negative Control (NC), Positive Control (PC), Reference Group (RG) glibenclamide 10 mg/kg BW, and ethanol extract of jengkol’s fruit peel (EEOJFP) treatment at dose of 385 (P1), 770 (P2), and 1540 (P3) mg/kg BW with four replications each. Treatment was administered orally for 14 days. Data were analyzed by analysis of variance (ANAVA) with 95% confidence level and Duncan Multiple Range Test. The result showed that treatment of EEOJFP with dose of 385, 770 and 1540 mg/ kgBW decreased blood glucose 28.6%;65.4% and 59.1% successively, increased insulin as 54%; 230% and 206%. There was a protective effect of EEOJEF to level of blood glucose and insulin secretion of rat-STZ induced. The conclusion from this research is Ethanol extract of Jengkol’s fruit peel at dose 770 mg/kg BW is an effective dose in decreasing the level of glucose and increasing the level of insulin hormone in STZinduced diabetic rats.
Erkenci Bölgede Üretilen Kiraz Çeşitlerinin Depo ve Raf Ömrünün Belirlenmesi
Authors: EROĞUL Deniz , ÖZMEN Birkan 
Published: January 2020

ÖZ

Amaç: Erkenci bölgede üretilen kiraz
çeşitlerinin hasat, depo ve raf ömrü sonrası meyve kalite özelliklerinin
belirlenmesi amaçlanmıştır.

Materyal
ve Metot: Kiraz çeşitleri
olarak Bing, Napolyon, North Wonder, Skeena, 0900 Ziraat ve Regina
kullanılmıştır. Meyveler modifiye
atmosfer paketleme (MAP) ambalajlarında 0±0.5°C sıcaklık ve %90-95 oransal
nemde 21 gün süreyle muhafaza edilmiştir. Depolama sonrası kalite analizi
yapılırken, bir kısım meyve 3 gün
süreyle raf ömrü (20°C sıcaklık ve %65-75 oransal nem) koşullarında tutulduktan
sonra meyve kalite analizleri gerçekleştirilmiştir.

Bulgular: Regina ve 0900 Ziraat
çeşitlerinde ağırlık kaybı az olmuş, meyve sertlikleride bu çeşitler ile North
Wonder çeşidinde yüksek bulunmuştur. Bing, Napolyon ve Skeena çeşitlerinin
meyve sertlikleri ise düşük bulunmuştur. Skeena çeşidi ve 0900 Ziraat çeşidinin
meyve ağırlıkları yüksek bulunmuştur. North Wonder ve Skeena çeşitlerinin çatlama oranı yüksek
olmuştur. Diğer kalite özelliklerinden suda çözünür kuru madde ve titre
edilebilir asitlik ve renk değerlerindeki değişim ise sınırlı olmuştur.

Sonuç: MAP
poşetleri ile depolama ve raf ömrü sonrası en iyi sonuç veren kiraz çeşitleri
0900 Ziraat ve Regina çeşitleri olmuştur.
0900 Ziraat çeşit özellikleri bakımından öne çıkmıştır.

Anahtar sözcükler: Erkenci bölge, Depolama, Kiraz, MA paketleme, Meyve
kalitesi, Raf ömrüDetermination of
Storage and Shelf Life of Sweet Cherry Varieties Produced in Early Region

ABSTRACT

Objectives: It was aimed to determine the fruit quality characteristics of the
cherry varieties produced in the early region after harvest, storage and shelf
life.

Material and Method: ‘Bing’, ‘Napoleon’,
‘North Wonder’, ‘Skeena’, ‘0900 Ziraat’ and ‘Regina’ were used as sweet cherry
varieties. Fruits were stored for 21 days at 0±0.5°C temperature and 90-95%
proportional humidity in modified atmospheric packaging (MAP). While the
quality analysis was performed after storage, fruit quality analyses were
carried out after some fruits were kept under shelf life conditions (20°C
temperature and 65-75% proportional humidity) for 3 days.

Results: Weight loss in ‘Regina’ and ‘0900 Ziraat’ varieties was minimal and
fruit firmness was found to be high in ‘North Wonder’ varieties, as well as,
these varieties. ‘Bing’, ‘Napoleon’ and ‘Skeena’ varieties were found to have
low fruit firmness. The fruit weights of the ‘Skeena’ variety and ‘0900 Ziraat’
variety were found to be high. The cracking rate of the ‘North Wonder’ and ‘Skeena’
varieties was high. Other quality features including the changes of soluble contents
and titrable acidity and color values were found to be limited.

Conclusion: The sweet
cherry varieties that give the best results after storage and shelf life with MAP
bags were 0900 Ziraat and Regina varieties. 0900 Ziraat excelled in terms of
various characteristics.

Keywords: Early area,
Storage, Sweet cherry, MA packaging, Fruit quality, Shelf life