bluuebunny/crossref_metadata_2025_split huggingface dataset:
STUDY PROTOCOL Glioma patients in outpatient care - Optimization of psychosocial care in neuro-oncological patients (GLIOPT): study protocol of a multicenter cluster randomized controlled trial
Authors: Renovanz Mirjam , Hippler Melina , Voss Martin , Wehinger Jens , Keßler Almuth F. , Gempt Jens , Nadji-Ohl Minou , Lucas Carolin Weiß , Rapp Marion , Misch Martin , Coburger Jan , Mehlitz Marcus , Meixensberger Jürgen , Keric Naureen , Tabatabai Ghazaleh , Blettner Maria , Schranz Melanie , Singer Susanne 
Published: March 2020

Abstract
Background: Patients with high-grade gliomas (HGG) often suffer from high distress and require psychosocial support. However, due to neurological and neurocognitive deficits, adequate assessment of distress and support needs remains a challenging unmet clinical need. The objective of the present study is to investigate whether a systematic implementation of signaling questions into the routine outpatient consultation will be helpful to bridge this gap.Methods and design : This is a multicenter cluster randomized study with two arms. Randomization is done on a cluster level with 13 hospitals providing regular neuro-oncological outpatient services conducted by neurologists and/or neurosurgeons. The intervention will include an assessment of psychosocial distress of patients in doctor-patient-conversationcompared to assessment of psychosocial distress via questionnaire (control, standard of care). In total, 616 HGG patients will be enrolled. The outcome will be the number of HGG patients with increased psychosocial distress who receive professional support from psychosocial services. Secondary endpoints are inter alia number of patients reporting psychosocial distress and unmet needs detected correctly by the respective method; quality of life; psychological well-being and burden of the patients before and after doctor-patient consultation as well as the length of the doctor-patient-consultation. Discussion: Patients with HGG are confronted with an oncological diagnosis and at the same time with high symptom burden. This often leads to distress, which is not always adequately recognized and treated. So far, only a limited number of adequate instruments are available to assess HGG patient's distress. Yet, an adequate care and support network might facilitate the course of the disease and tumor therapies for patients. Our hypothesis is that an assessment conducted directly by attending doctors and in which the doctors talk to patients with HGG will be more effective than an assessment via a questionnaire, leading to better identifying patients in need for support. This may lead to an improvement of health care in these patients. Further, this method might be implemented also in other brain tumor patients (e.g. patients with brain metastases).Trial registration: Register: German Clinical Trials Register, registration number: DRKS00018079 Registration date: 3 rd September 2019, URL: http://www.drks.de/DRKS00018079
Comparison of fetal and plasma fibronectin concentrations in diagnosis of Preterm: delivery A cross sectional, descriptive-analytical study
Authors: moradi zahra , Meshkibaf mohamadHassan , Jafarzadeh Saeedeh , Dehghan Azizallah , Moradi parvin , Keshavarzi Ameneh 
Published: March 2020

Abstract
Background Preterm delivery is amongst the main reasons for child mortality. Therefore, its prediction can reduce a large number of its complications. The present study aimed to compare fetal and plasma fibronectin concentrations in diagnosis of preterm delivery. Methods Serum samples were obtained from 105 women at 24-36 weeks of gestation. However, only 40 women gave permission for taking vaginal samples. Fibronectin concentration was measured using ELISA technique. Then, plasma and fetal fibronectin levels were compared in term and preterm deliveries. Results Out of the 105 participants, 28 experienced preterm delivery (26.7%). The mean gestational age at the time of sampling was 28.11 + 2.98 weeks. The mean plasma fibronectin level was 6226.43+7174.97 ng/ml among the mothers with term infants and 7724.01 + 1143.82 ng/ml among those with preterm infants. Although the mean plasma fibronectin level was higher in preterm delivery, the difference was not statistically significant (p=0.667). The mean fetal fibronectin level was 156.61 + 126.42 ng/ml among the mothers with term infants and 127.71 + 43.14 ng/ml among those with preterm infants, but the difference was not statistically significant (p=0.241). The cut-off point of plasma fibronectin level was 1750 ng/ml with the sensitivity of 80.25% and specificity of 85.17%. Additionally, the cut-off point of fetal fibronectin level was 158.98 ng/ml with the sensitivity of 94.62% and specificity of 22.08%. Conclusion Plasma fibronectin testing had lower sensitivity and higher specificity compared to fetal fibronectin testing. This implies that plasma testing has lower false positive cases and can identify a larger number of true positive cases of preterm delivery.
Misfortune never comes singly - the first case of COVID-19 with rupture of thoracic aortic aneurysm
Authors: Zhao Kun , Cao Zhang , Zhu Changju , Zhang Yi , Chen Feifan 
Published: March 2020

Abstract
Background: SARS-CoV-2 is a newly discovered virus, leading COVID-19 a global threaten nowadays. Case Presentation: The first case of a patient with a thoracic aortic aneurysm (TAA) that became infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported here. The patient died suddenly from a ruptured aorta 19 h after hospital admission. Conclusion: COVID-19 patients with TAA should attract the highest vigilance as COVID-19 might expedite the process of TAA rupture through cytokine storm syndrome, leading to rapid death with little or no warning signs.
Clinical characteristics of Coronavirus Disease 2019 outside Wuhan and development of early risk stratification tool
Authors: Hong Yucai , Huang Jianping , Chen Dong , Ye Yinghai , Su Feifei , Dai Jianyi , Shi Jichan , Shao Chaochao , Zhang Zhongheng 
Published: March 2020

Abstract
Importance: Clinical characteristics of coronavirus disease 2019 (COVID-19) outside Wuhan are not well described, and there is no risk stratification tool for the prediction of COVID-19 outcome.Objective: To describe the clinical characteristics of COVID-19 outside Wuhan and to develop a risk stratification tool for early risk stratification.Design, Setting, and Participants: Single center, retrospective observational study conducted at Wenzhou, Zhejiang province (January 2020-February 2020) that included 140 patients with confirmed COVID-19. Clinical characteristics were described. A multivariate regression model was built to predict the risk of length of stay in hospital > 20 days (ProLOS). The last patient visit was on February 23, 2020.Interventions: NoneMain Outcomes and Measures: The primary outcome was ProLOS. Other outcomes included conversion to negative nucleic acid test, date of hospital discharge, vital status at discharge.Results: A total of 140 patients were included during the study period. Lower lymphocyte count (1.0 [0.7, 1.3] vs. 1.3 [0.9, 1.72] × 109/𝐿; p = 0.008), lower ionized sodium (136 [134.6, 137.83] vs. 138 [135.28, 140.03] mmol/L; p < 0.001) and higher PaCO2 (40.82 ± 3.96 vs. 38.48 ± 5.48 mmHg; p = 0.007) were associated with higher risk of ProLOS. The median time from hospital admission to the first negative nucleic acid test was 13 days (7.25 to 17 days). There were 4 (3%) critically and 5 (4%) severely ill patients. A multivariate model included predictors of age, time from contact to confirmation, DBP, lymphocyte count, AST, ionized sodium, PaCO2 showed good calibration and discrimination with an AUC of 81.6% (95% CI: 74.4% to 88.8%).Conclusions and Relevance: The study described clinical characteristics of COVID-19 outside Wuhan. The major difference of COVID-19 in other cities included low comorbidity burden, low prevalence of severe or critical cases and low mortality rate. The risk stratification tool can be used for medical decision making and resource allocation.Authors Yucai Hong and Jianping Huang contributed equally to this work and are co-first authors.
Daily flow forecasting of perennial rivers in an arid watershed: a hybrid ensemble decomposition approach integrated with computational intelligence techniques
Authors: Torabi Seyed Alireza , Mastouri Reza , Najarchi Mohsen 
Published: March 2020

Abstract
Accurate estimating of daily streamflow forecasting is one of the prominent topics in water resources activities. In this paper, an integrated method including decomposition technique based on the ensemble empirical mode decomposition (EEMD) combined with multivariate adaptive regression spline (MARS) was carried out to predict daily streamflow values. Daily streamflow value datasets collected from two stations in Iran (Gachsar and Kordkheyl) were selected. After dividing into calibration and validation datasets, each of them was decomposed by EEMD. Crow search algorithm (CSA) was used to optimize the MARS parameters (MARS-CSA). The performance of the integrated model (EEMD-MARS-CSA) was investigated by error indices (correlation coefficient (R), root mean squared error (RMSE), mean absolute error (MAE), Nash–Sutcliffe efficiency (NSE), as well as RMSE to standard deviation ratio (RSR)). From the results, EEMD was an important tool for increasing model accuracy and EEMD-MARS-CSA outperformed other alternative methods for daily streamflow estimation. According to one-day-ahead flow forecasting, EEMD-MARS-CSA (R = 0.94, RMSE = 5.94 m3/s (Kordkheyl) and R = 0.98, RMSE = 0.71 m3/s (Gachsar)) outperformed EEMD-MT/MARS, MT, and MARS models. Furthermore, RSR criterion of EEMD-MARS-CSA was reduced by 18%, 16%, and 17% for 3-days, 1-week, and 2-weeks-ahead streamflow forecasting compared to MARS-CSA model, respectively, for Gachsar station.
Design of Lamivudine Loaded Nanoparticles for Oral Application by Nano Spray Drying Method: A New Approach to use an Antiretroviral Drug for Lung Cancer Treatment
Authors: Öztürk Ahmet Alper , Namlı İrem , Güleç Kadri , Görgülü Şennur 
Published: March 2020

Aims:To prepare lamivudine (LAM)-loaded-nanoparticles (NPs) that can be used in lung cancer treatment. To change the antiviral indication of LAM to anticancer.Background:The development of anticancer drugs is a difficult process. One approach to accelerate the availability of drugs is to reclassify drugs approved for other conditions as anticancer. The most common route of administration of anticancer drugs is intravenous injection. Oral administration of anticancer drugs may considerably change current treatment modalities of chemotherapy and improve the life quality of cancer patients. There is also a potentially significant economic advantage.Objective:To characterize the LAM-loaded-NPs and examine the anticancer activity.Methods:LAM-loaded-NPs were prepared using Nano Spray-Dryer. Properties of NPs were elucidated by particle size (PS), polydispersity index (PDI), zeta potential (ZP), SEM, encapsulation efficiency (EE%), dissolution, release kinetics, DSC and FT-IR. Then, the anticancer activity of all NPs was examined.Results:The PS values of the LAM-loaded-NPs were between 373 and 486 nm. All NPs prepared have spherical structure and positive ZP. EE% was in a range of 61-79%. NPs showed prolonged release and the release kinetics fitted to the Weibull model. NPs structures were clarified by DSC and FT-IR analysis. The results showed that the properties of NPs were directly related to the drug:polymer ratio of feed solution. NPs have potential anticancer properties against A549 cell line at low concentrations and non-toxic to CCD 19-Lu cell line.Conclusion:NPs have potential anticancer properties against human lung adenocarcinoma cells and may induce cell death effectively and be a potent modality to treat this type of cancer. These experiments also indicate that our formulations are non-toxic to normal cells. It is clear that this study would bring a new perspective to cancer therapy.
An Insight into Nanomedicinal Approaches to Combat Viral Zoonoses
Authors: Minakshi Prasad , Ghosh Mayukh , Kumar Rajesh , Brar Basanti , Lambe Upendra P. , Banerjee Somesh , Ranjan Koushlesh , Kumar Balvinder , Goel Parveen , Malik Yashpal S. , Prasad Gaya 
Published: March 2020

Background:Emerging viral zoonotic diseases are one of the major obstacles to secure the “One Health” concept under the current scenario. Current prophylactic, diagnostic and therapeutic approaches often associated with certain limitations and thus proved to be insufficient for customizing rapid and efficient combating strategy against the highly transmissible pathogenic infectious agents leading to the disastrous socio-economic outcome. Moreover, most of the viral zoonoses originate from the wildlife and poor knowledge about the global virome database renders it difficult to predict future outbreaks. Thus, alternative management strategy in terms of improved prophylactic vaccines and their delivery systems; rapid and efficient diagnostics and effective targeted therapeutics are the need of the hour.Methods:Structured literature search has been performed with specific keywords in bibliographic databases for the accumulation of information regarding current nanomedicine interventions along with standard books for basic virology inputs.Results:Multi-arrayed applications of nanomedicine have proved to be an effective alternative in all the aspects regarding the prevention, diagnosis, and control of zoonotic viral diseases. The current review is focused to outline the applications of nanomaterials as anti-viral vaccines or vaccine/drug delivery systems, diagnostics and directly acting therapeutic agents in combating the important zoonotic viral diseases in the recent scenario along with their potential benefits, challenges and prospects to design successful control strategies.Conclusions:This review provides significant introspection towards the multi-arrayed applications of nanomedicine to combat several important zoonotic viral diseases.
Assessment of Key Elements in the Innate Immunity System Among Patients with HIV, HCV, and Coinfections of HIV/HCV
Authors: Moradi Maryam , Tabibzadeh Alireza , Javanmard Davod , Ghorbani Saied , Bokharaei-Salim Farah , Keivani Hosein , Khazeni Mohammad , Monavari Seyed Hamid Reza 
Published: March 2020

Background:
Coinfection of Hepatitis C virus (HCV) with human immunodeficiency
virus (HIV) has a higher risk of mortality than HCV or HIV monoinfection. HCV and HIV infections
are specified by systemic inflammation, but the inflammation process in HCV/HIV coinfection
is much complicated and is not well characterized.

Objective:
The aim of this study was to analyze the expression of TLR-3, TLR-7, IL-10, IFN-1
(IFN-α, IFN-β), and TNF-α in HIV, HCV and HIV/HCV co-infected patients.

Methods:
Forty-five patients including HIV group (n=15), HCV group (n=15), HIV/HCV coinfection
group (n=15) and healthy control group (n=15) participated. Peripheral blood mononuclear
cells (PBMCs) were obtained. PBMC-RNA, HCV and HIV RNA were extracted from all subjects
and cDNA was synthesized. The viral load analyzed by reverse transcription-quantitative PCR
(RT-qPCR), and the expression levels of IFN-α, IFN-β, TLR-3, TLR-7, TNF, and IL-10 mRNA
were quantified in PBMCs.

Results:
The levels of IFN-I, IL-10, and TNF-α were overexpressed in all patients’ groups
(P<0.05), TLR-7 was upregulated in all groups, but this upregulation was not statistically significant
(p>0.05). TLR-3 showed a decrease in all patient groups (P<0.05). The statistical analysis
demonstrated that TLR-3 has a negative correlation with HIV load, whereas other genes positively
correlated with HIV load. In addition, TLR-3, TNF-α, and IFN-I were negatively correlated with
HCV load, whereas TLR-7 and IL-10 s were positively correlated with HCV load.

Conclusion:
Our results showed a significant relationship between the expression level of innate
immunity genes and inflammation in HCV, HIV, and HIV/HCV coinfected patients.
Sustainable Campus Income Generation Initiative and Social Entrepreneurship at a Public University
Authors: Hashim Rugayah Gy , Md Sharif Mohd Shazali , Muhammad Rosmaliza , Aminuddin Zaidi Mohd 
Published: March 2020

Campuses with substantial acreage have the advantage of biodiversity, populace, and facilities that would allow the initiation of multi projects for income generation and sustainability. For Universiti Teknologi MARA Cawangan Selangor (UCS), the fish pekasam project originated from the natural resources available on campus, which are the twelve lakes inhabited with tilapias and other fishes. Elements of social entrepreneurship from the sale of the pekasam (fermented) fish allowed for income generation to the campus. Aside from that, direct training was given to the students and staff who participated in the project. The initiative helped increase the campus's happiness index.Keywords: sustainable campus; narrative research; social entrepreneurship; fish pekasameISSN: 2398-4287 © 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v5i13.1948
Understanding and Measuring the Determinants of Employees’ Turnover Intention
Authors: Munir Ros Intan Safinas , Mohd Tobi Siti Noraini 
Published: March 2020

Employees’ turnover intention has become a serious issue in manufacturing sector in Malaysia. Recent statistics identified that Malaysian workers leaving their job after six months of working are relatively high. This study aims to examine the relationship between employees’ turnover intention and its predictors. A self-administered questionnaire was distributed to 210 employees in manufacturing sector in the North Region, Peninsular Malaysia. The findings confirm that the work environment factors, i.e. workload, job safety and security, and relationship with co-workers affect the turnover intention. These findings outline implications for organization in developing new strategies to retain their employees.Keywords: Turnover Intention; Work Environment; Manufacturing SectoreISSN: 2398-4287 © 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v5i13.2092
Trajectories of Serum Sodium on In-Hospital and 1-Year Survival among Hospitalized Patients
Authors: Chewcharat Api , Thongprayoon Charat , Cheungpasitporn Wisit , Mao Michael A. , Thirunavukkarasu Sorkko , Kashani Kianoush B. 
Published: March 2020

Background and objectives
This study aimed to investigate the association between in-hospital trajectories of serum sodium and risk of in-hospital and 1-year mortality in patients in hospital.

Design, setting, participants, & measurements
This is a single-center cohort study. All adult patients who were hospitalized from years 2011 through 2013 who had available admission serum sodium and at least three serum sodium measurements during hospitalization were included. The trend of serum sodium during hospitalization was analyzed using group-based trajectory modeling; the five main trajectories were grouped as follows: (1) stable normonatremia, (2) uncorrected hyponatremia, (3) borderline high serum sodium, (4) corrected hyponatremia, and (5) fluctuating serum sodium. The outcome of interest was in-hospital mortality and 1-year mortality. Stable normonatremia was used as the reference group for outcome comparison.

Results
A total of 43,539 patients were analyzed. Of these, 47% had stable normonatremia, 15% had uncorrected hyponatremia, 31% had borderline high serum sodium, 3% had corrected hyponatremia, and 5% had fluctuating serum sodium trajectory. In adjusted analysis, there was a higher in-hospital mortality among those with uncorrected hyponatremia (odds ratio [OR], 1.33; 95% CI, 1.06 to 1.67), borderline high serum sodium (OR, 1.66; 95% CI, 1.38 to 2.00), corrected hyponatremia (OR, 1.50; 95% CI, 1.02 to 2.20), and fluctuating serum sodium (OR, 4.61; 95% CI, 3.61 to 5.88), compared with those with the normonatremia trajectory. One-year mortality was higher among those with uncorrected hyponatremia (hazard ratio [HR], 1.28; 95% CI, 1.19 to 1.38), borderline high serum sodium (HR, 1.18; 95% CI, 1.11 to 1.26), corrected hyponatremia (HR, 1.24; 95% CI, 1.08 to 1.42), and fluctuating serum sodium (HR, 2.10; 95% CI, 1.89 to 2.33) compared with those with the normonatremia trajectory.

Conclusions
More than half of patients who had been hospitalized had an abnormal serum sodium trajectory during hospitalization. This study demonstrated that not only the absolute serum sodium levels but also their in-hospital trajectories were significantly associated with in-hospital and 1-year mortality. The highest in-hospital and 1-year mortality risk was associated with the fluctuating serum sodium trajectory.

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2020_03_25_CJN.12281019.mp3
MD&A Textual Similarity and Auditors
Authors: De Franco Gus , Fogel-Yaari Hila , Li Heather 
Published: March 2020

SUMMARY
This study examines the relation between auditors and the unaudited Management Discussion and Analysis (MD&A). We show that MD&As are more textually similar when firms share the same auditor. This result suggests that auditors influence MD&As to be more textually similar merely by reviewing the MD&A. We next show that auditor-related MD&A similarity is positively associated with MD&A readability and that the market reacts to auditor-related MDA modifications. These results provide modest evidence that auditor-related MD&A similarity may improve the MD&A's disclosure quality, consistent with the general idea that more audit influence is a positive financial reporting characteristic.