bluuebunny/crossref_metadata_2025_split huggingface dataset:
CODEX clusters
Authors: Finoguenov A. , Rykoff E. , Clerc N. , Costanzi M. , Hagstotz S. , Ider Chitham J. , Kiiveri K. , Kirkpatrick C. C. , Capasso R. , Comparat J. , Damsted S. , Dupke R. , Erfanianfar G. , Patrick Henry J. , Kaefer F. , Kneib J.-P. , Lindholm V. , Rozo E. , van Waerbeke L. , Weller J. 
Published: May 2020

Context. Large area catalogs of galaxy clusters constructed from ROSAT All-Sky Survey provide the basis for our knowledge of the population of clusters thanks to long-term multiwavelength efforts to follow up observations of these clusters.
Aims. The advent of large area photometric surveys superseding previous, in-depth all-sky data allows us to revisit the construction of X-ray cluster catalogs, extending the study to lower cluster masses and higher redshifts and providing modeling of the selection function.
Methods. We performed a wavelet detection of X-ray sources and made extensive simulations of the detection of clusters in the RASS data. We assigned an optical richness to each of the 24 788 detected X-ray sources in the 10 382 square degrees of the Baryon Oscillation Spectroscopic Survey area using red sequence cluster finder redMaPPer version 5.2 run on Sloan Digital Sky Survey photometry. We named this survey COnstrain Dark Energy with X-ray (CODEX) clusters.
Results. We show that there is no obvious separation of sources on galaxy clusters and active galactic nuclei (AGN) based on the distribution of systems on their richness. This is a combination of an increasing number of galaxy groups and their selection via the identification of X-ray sources either by chance or by groups hosting an AGN. To clean the sample, we use a cut on the optical richness at the level corresponding to the 10% completeness of the survey and include it in the modeling of the cluster selection function. We present the X-ray catalog extending to a redshift of 0.6.
Conclusions. The CODEX suvey is the first large area X-ray selected catalog of northern clusters reaching fluxes of 10−13 ergs s−1 cm−2. We provide modeling of the sample selection and discuss the redshift evolution of the high end of the X-ray luminosity function (XLF). Our results on z <  0.3 XLF agree with previous studies, while we provide new constraints on the 0.3 <  z <  0.6 XLF. We find a lack of strong redshift evolution of the XLF, provide exact modeling of the effect of low number statistics and AGN contamination, and present the resulting constraints on the flat ΛCDM.
Increasing the raw contrast of VLT/SPHERE with the dark hole technique
Authors: Potier A. , Galicher R. , Baudoz P. , Huby E. , Milli J. , Wahhaj Z. , Boccaletti A. , Vigan A. , N’Diaye M. , Sauvage J.-F. 
Published: May 2020

Context. Since 1995 and the first discovery of an exoplanet orbiting a main-sequence star, 4000 exoplanets have been discovered using several techniques. However, only a few of these exoplanets were detected through direct imaging. Indeed, the imaging of circumstellar environments requires high-contrast imaging facilities and accurate control of wavefront aberrations. Ground-based planet imagers such as VLT/SPHERE or Gemini/GPI have already demonstrated great performance. However, their limit of detection is hampered by suboptimal correction of aberrations unseen by adaptive optics (AO).
Aims. Instead of focusing on the phase minimization of the pupil plane as in standard AO, we aim to directly minimize the stellar residual light in the SPHERE science camera behind the coronagraph to improve the contrast as close as possible to the inner working angle.
Methods. We propose a dark hole (DH) strategy optimized for SPHERE. We used a numerical simulation to predict the global improvement of such a strategy on the overall performance of the instrument for different AO capabilities and particularly in the context of a SPHERE upgrade. Then, we tested our algorithm on the internal source with the AO in closed loop.
Results. We demonstrate that our DH strategy can correct for aberrations of phase and amplitude. Moreover, this approach has the ability to strongly reduce the diffraction pattern induced by the telescope pupil and the coronagraph, unlike methods operating at the pupil plane. Our strategy enables us to reach a contrast of 5e−7 at 150 mas from the optical axis in a few minutes using the SPHERE internal source. This experiment establishes the grounds for implementing the algorithm on sky in the near future.
Behandlung des Tourette-Syndroms mit cannabisbasierten Medikamenten
Authors: Müller-Vahl Kirsten R. 
Published: May 2020

ZUSAMMENFASSUNGDie Behandlung von Patienten mit Gilles-de-la-Tourette-Syndrom (GTS) ist bis heute unbefriedigend, da etablierte Therapien nur zu einer partiellen Reduktion der Tics und nicht zu einer Verbesserung psychiatrischer Komorbiditäten führen. Die medikamentöse Behandlung mit Antipsychotika führt oft zu relevanten Nebenwirkungen. Daher besteht großes Interesse, neue Behandlungsstrategien zu entwickeln. Basierend auf anekdotischen Berichten und kleinen Studien, in denen über positive Effekte durch Cannabis und cannabisbasierte Medikamente bei Patienten mit GTS berichtet wurde, wird in kontrollierten Studien untersucht, ob Medikamente, die durch unterschiedliche Mechanismen zu einer Stimulation des Endocannabinoidsystems führen, wirksam und verträglich in der Therapie von Tics und Komorbiditäten sind. In dieser Übersicht werden bisherige Studienergebnisse vorgestellt. Es werden Hypothesen diskutiert, warum Cannabinoide in der Behandlung des GTS wirksam sein könnten. Schließlich werden praktische Empfehlungen zur Therapie mit cannabisbasierten Medikamenten gegeben.
Tiefe Hirnstimulation als Therapieoption für das Tourette-Syndrom
Authors: Mainka Tina , Ganos Christos , Kühn Andrea A. , Marcelino Ana Luísa de A. 
Published: May 2020

ZUSAMMENFASSUNGDas Tourette-Syndrom (TS) ist eine neuropsychiatrische Erkrankung, die durch das Auftreten motorischer und vokaler Tics charakterisiert ist. Bei einem geringen Teil der Patienten sind die Symptome durch medikamentöse und behaviorale Therapie nicht ausreichend gut behandelbar. Hier kann eine Therapieeskalation erwogen werden. Die tiefe Hirnstimulation (THS) ist ein invasives Therapieverfahren, das bei bestimmten Bewegungsstörungen etabliert ist und für die Therapie des TS zunehmend an Bedeutung gewinnt. Der folgende Artikel fasst die aktuelle Evidenz zur Anwendung der THS beim TS zusammen. Die meiste Erfahrung liegt für die thalamische und pallidale Stimulation vor, wobei bisher keines der Zielgebiete deutlich überlegen war. Die Studienlage zeigt eine durchschnittliche Reduktion der Tic-Schwere unter THS von bis zu 40 % nach einem Jahr. Inwiefern die THS zu einer Besserung der oft begleitenden psychiatrischen Komorbiditäten führt, bleibt aufgrund der geringen Fallzahlen unsicher. Beim TS ist eine erhöhte Anzahl an postoperativen Infektionen aufgefallen, deren Ursache nicht geklärt wurde. Zusammenfassend zeigen die Studien, dass eine THS beim TS eine sichere Therapieoption zur Behandlung schwerer medikamentös nicht behandelbarer Tics darstellt. Die THS sollte an Zentren durchgeführt werden, in denen Expertise sowohl in der Behandlung von Tics als auch für THS vorliegt.
Behandlung des Primärtumors beim oligometastasierten Prostatakarzinom
Authors: Bottke Dirk , Wiegel Thomas 
Published: May 2020

ZusammenfassungBei der Therapie des metastasierten Prostatakarzinoms wurden in letzter Zeit deutliche Fortschritte erzielt. Zusätzlich zur Androgendeprivation stehen verschiedene Optionen zur Verfügung, wie gegen den Androgenrezeptor gerichtete Therapien und die Taxan-basierte Chemotherapie. Nach wie vor wird diskutiert, ob oligometastasierte Patienten primär nur systemisch behandelt werden sollten, ober ob sie von einer zusätzlichen Lokaltherapie des Primärtumors profitieren. Bis Mitte 2018 gab es keine evidenzbasierte Empfehlung, bei neu diagnostiziertem Prostatakarzinom mit Fernmetastasen eine lokale Bestrahlung der Prostata durchzuführen. Diese konnte als Einzelfallentscheidung aufgrund der Daten retrospektiver Serien indiziert werden. Dementsprechend gab es hierzu keine Empfehlungen in den Leitlinien. Durch die 2018 /19 publizierten Daten der STAMPEDE- und der HORRAD-Studie ist die Indikation zu einer lokalen Bestrahlung des Primärtumors beim oligometastasierten Prostatakarzinom mit weniger als 4 Knochenmetastasen nun klar belegt. Die folgende Übersicht fasst die Daten der beiden Studien zusammen, bewertet diese und gibt eine Empfehlung für den Einsatz der lokalen Strahlentherapie der Prostata in der oligometastasierten Situation.
Tics und Tourette-Störung für die Praxis
Authors: Ganos Christos , Djodari-Irani Anaïs 
Published: May 2020

ZUSAMMENFASSUNGPrimäre Tic-Störungen und das Tourette-Syndrom (TS) sind häufige neuropsychiatrische Erkrankungen, die sich im frühen Lebensalter manifestieren und durch motorische und/oder vokale Tics gekennzeichnet sind. Oftmals bestehen bei den Betroffenen psychiatrische Komorbiditäten wie Zwangsstörungen, Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung, Angst- und affektive Störungen. Differenzialdiagnostisch stellen neben anderen Bewegungsstörungen wie zum Beispiel Chorea oder Stereotypien, die funktionellen Tic-ähnlichen Störungen eine besondere Herausforderung dar. Tiermodelle, Post-mortem-Studien, behaviorale und bildgebende Studienbefunde weisen auf Veränderungen im kortiko-striato-thalamo-kortikalen Regelkreis in der primären Tic-Störung und dem TS hin, wobei in der Genese dieser Erkrankungen das dopaminerge System eine wichtige Rolle zu spielen scheint. Therapeutisch werden spezifische verhaltenstherapeutische Strategien wie das Habit Reversal Learning oder das Exposure and Response Prevention in erster Linie empfohlen. Pharmakotherapien beinhalten antipsychotische Medikation, Botulinumtoxin-Injektionen sowie cannabisbasierte Medikamente. In therapieresistent verlaufenden Fällen kann die tiefe Hirnstimulation erwogen werden.
Anterolateral Ligament Reconstruction Improves Anteroposterior Stability As Well As Rotational Stability in Revision Anterior Cruciate Ligament Reconstruction with High-Grade Pivot Shift
Authors: Yoon Kyoung Ho , Hwang In Uk , Kim Eung Ju , Kwon Yoo Beom , Kim Sang-Gyun 
Published: May 2020

AbstractThis study aimed to investigate the effect of anterolateral ligament reconstruction (ALLR) in revision anterior cruciate ligament reconstruction (ACLR) with high-grade pivot shift. The hypothesis was that revision ACLR combined with ALLR (RACLR with ALLR group) would show superior clinical outcomes to those of isolated revision ACLR. We retrospectively evaluated consecutive patients who underwent revision ACLR (RACLR) combined with ALLR between October 2015 and January 2017. The indication for combination of ALLR with revision ACLR was failed ACLR with ≥G2 pivot-shift instability. The control group included patients who underwent isolated revision ACLR (isolated RACLR group) for the same indication between July 2013 and September 2015. Exclusion criteria were ≤G1 pivot-shift instability, multiple ligament reconstruction, bilateral ligament injury, double-bundle reconstruction, insufficient medical records, postoperative infection, and follow-up loss at postoperative 2 years. Clinical scores, stability tests, and failure rates were compared between groups at the 2-year follow-up. The RACLR with ALLR group had 18 patients (mean age, 32.9 ± 10.8 years) and the RACLR group had 21 patients (mean age, 29.6 ± 10.2 years). Clinical scores at the 2-year follow-up showed no significant differences between groups. However, the RACLR with ALLR group showed better stability in the Lachman test (p = 0.005), pivot-shift test (p = 0.030), and side-to-side difference in stress radiographs (3.9 ± 3.0 mm vs. 5.9 ± 2.8 mm, p = 0.018) than the isolated RACLR group. The RACLR with ALLR group had two failures (11.1%), and the RACLR group had three failures (14.3%). In conclusion, ALLR in revision ACLR with high-grade pivot shift improves anteroposterior stability as well as rotational stability at 2-year follow-up. Therefore, ALLR is recommended with revision ACLR, especially in patients with high-grade pivot shift. This is a Level III, retrospective cohort review.
Platelet Activation via Shear Stress Exposure Induces a Differing Pattern of Biomarkers of Activation versus Biochemical Agonists
Authors: Roka-Moiia Yana , Walk Ryan , Palomares Daniel E. , Ammann Kaitlyn R. , Dimasi Annalisa , Italiano Joseph E. , Sheriff Jawaad , Bluestein Danny , Slepian Marvin J. 
Published: May 2020

Abstract
Background Implantable cardiovascular therapeutic devices, while hemodynamically effective, remain limited by thrombosis. A driver of device-associated thrombosis is shear-mediated platelet activation (SMPA). Underlying mechanisms of SMPA, as well as useful biomarkers able to detect and discriminate mechanical versus biochemical platelet activation, are poorly defined. We hypothesized that SMPA induces a differing pattern of biomarkers compared with biochemical agonists.
Methods Gel-filtered human platelets were subjected to mechanical activation via either uniform constant or dynamic shear; or to biochemical activation by adenosine diphosphate (ADP), thrombin receptor-activating peptide 6 (TRAP-6), thrombin, collagen, epinephrine, or arachidonic acid. Markers of platelet activation (P-selectin, integrin αIIbβ3 activation) and apoptosis (mitochondrial membrane potential, caspase 3 activation, and phosphatidylserine externalization [PSE]) were examined using flow cytometry. Platelet procoagulant activity was detected by chromogenic assay measuring thrombin generation. Contribution of platelet calcium flux in SMPA was tested employing calcium chelators, ethylenediaminetetraacetic acid (EDTA), and BAPTA-AM.
Results Platelet exposure to continuous shear stress, but not biochemical agonists, resulted in a dramatic increase of PSE and procoagulant activity, while no integrin αIIbβ3 activation occurred, and P-selectin levels remained barely elevated. SMPA was associated with dissipation of mitochondrial membrane potential, but no caspase 3 activation was observed. Shear-mediated PSE was significantly decreased by chelation of extracellular calcium with EDTA, while intracellular calcium depletion with BAPTA-AM had no significant effect. In contrast, biochemical agonists ADP, TRAP-6, arachidonic acid, and thrombin were potent inducers of αIIbβ3 activation and/or P-selectin exposure. This differing pattern of biomarkers seen for SMPA for continuous uniform shear was replicated in platelets exposed to dynamic shear stress via circulation through a ventricular assist device-propelled circulatory loop.
Conclusion Elevated shear stress, but not biochemical agonists, induces a differing pattern of platelet biomarkers—with enhanced PSE and thrombin generation on the platelet surface. This differential biomarker phenotype of SMPA offers the potential for early detection and discrimination from that mediated by biochemical agonists.
The Efficacy and Safety of Low Molecular Weight Heparin Administration to Improve Survival of Cancer Patients: A Systematic Review and Meta-Analysis
Authors: Montroy Joshua , Lalu Manoj M. , Auer Rebecca C. , Grigor Emma , Mazzarello Sasha , Carrier Marc , Kimmelman Jonathan , Fergusson Dean A. 
Published: May 2020

Abstract
Background Low molecular weight heparins (LMWH) are often used as a first-line therapy for the prevention of thrombosis in cancer patients. Preclinical evidence from animal models suggests that LMWH may have antimetastatic properties. Clinical evidence of this effect is inconclusive. The objective of this systematic review is to evaluate the effect of LMWH on overall survival in patients with solid tumor malignancies.
Methods MEDLINE, Embase, and The Cochrane Central Register of Controlled trials were searched from inception to November 26, 2018. We included randomized controlled trials that compared LMWH to placebo, a no-treatment arm, or a short-term prophylactic course of LMWH in adult patients with solid tumors. The primary outcome was overall survival. Secondary outcomes included progression-free survival, the occurrence of venous thromboembolism, and major bleeding events. The risk of bias was assessed in duplicate using the Cochrane Risk-of-Bias tool.
Results Forty-five articles were included in the review. Overall, no difference in overall survival was observed between groups (risk ratio: 1.00; 95% confidence interval: 0.98–1.02; I2 = 36.5%). In our a priori defined subgroup analyses, the effect was not shown to vary by the type of LMWH, duration of LMWH use, length of study follow-up, comparator used in the study, or the setting in which the LMWH was administered. The majority of studies had an unclear risk of bias for at least one methodological criterion.
Conclusion Although LMWH is thought to possess antimetastatic properties and thus have the potential to improve survival in cancer patients, existing data do not support this hypothesis.
Positive epistasis between viral polymerase and the 3′ untranslated region of its genome reveals the epidemiologic fitness of dengue virus
Authors: Syenina Ayesa , Vijaykrishna Dhanasekaran , Gan Esther Shuyi , Tan Hwee Cheng , Choy Milly M. , Siriphanitchakorn Tanamas , Cheng Colin , Vasudevan Subhash G. , Ooi Eng Eong 
Published: May 2020

Significance
Dengue affects approximately one-half of the world’s population. While it causes regular and cyclical outbreaks throughout the tropical world, the molecular mechanisms that determine its epidemic potential remain poorly defined. The present work provides insight into the molecular determinants of epidemiologic fitness, which is critical for surveillance to identify dengue virus strains with a potential to cause outbreaks. This will allow for better implementation of control measures to intercept impending outbreaks before many lives are affected.
Human sleep consolidates allergic responses conditioned to the environmental context of an allergen exposure
Authors: Besedovsky Luciana , Benischke Mona , Fischer Jörg , Yazdi Amir S. , Born Jan 
Published: May 2020

Significance
Allergic disorders are widespread and can strongly affect quality of life. Here we show in humans that an allergic response can be triggered even in the absence of allergens by simply reencountering the environmental context in which an allergen was previously administered. This effect occurred only when participants slept during the night after allergen administration and was entirely absent when they stayed awake on that night, demonstrating that sleep is necessary for consolidating the association between environmental context and allergen. These findings have important implications for understanding the often observed “placebo” allergic responses occurring in the absence of allergens.
Correlation between near scrape-off layer power fall-off length and confinement properties in JET operated with carbon and ITER-like wall
Authors: Faitsch M , Eich T , Sieglin B 
Published: May 2020

Abstract
Combining high plasma core performance with a suitable power exhaust solution is one of the major challenges in magnetic confinement fusion research. One of the most important power exhaust parameters is the power fall-off length in the scrape-off layer. Two infrared thermography based power fall-off length data sets from JET operated with carbon and ITER-like wall are revisited and compared to recently published scaling laws as well as to confinement and pedestal top parameters. It is shown that the power fall-off length is correlated to confinement, with the highest correlation among the tested parameters being the pedestal top density. The power fall-off length decreases with increasing pedestal top density in variance to the multi-machine scaling law. A similar trend is observed for the pedestal top pressure. This is in agreement with findings at C-Mod showing a scaling of the power fall-off length in various confinement regimes with the volume averaged pressure. Further, it is shown that a variation of the safety factor at constant pedestal top density is not changing the power fall-off length significantly in the two JET data sets.
Prepare of nanocomposite structures through the magnetron deposition of material on the colloidal silica films and investigation of their properties
Authors: Galaganova E N , Sotnikov D A 
Published: May 2020

Abstract
The paper presents a study of nanocomposite structures prepared by magnetron sputtering of titanium on a template formed during the deposition of colloidal silica particles on a metal substrate. The effect of power and spraying time on the formation of nanocomposite structures was studied. The features of the processes of growth of a metal film on an opal matrix and the Implantation of metal into its structure are revealed.
A Realization Method of Video Information Exchange for Network Connected Vehicles
Authors: Zhan Deyou , Jiao Qingchun , Song Binghui 
Published: May 2020

Abstract
This article through the design which has the function of transcoding, distribution and authentication exchange unit, achieve a face made car video information exchange method. REST method is used to realize the interface call of video information exchange, which includes control flow, media flow and structured data flow of video content analysis results. It can be used in video exchange scenarios of vehicle and vehicle, vehicle and infrastructure, vehicle and remote management platform.
Longitudinal and Lateral Velocity Estimation based on Covariance Inverse Robust Fusion
Authors: Huang Junhao , Wei Wei , Hu Junshuai 
Published: May 2020

Abstract
Accurate estimation of vehicle longitudinal and lateral velocity is meaningful for internal system. Aiming at improving the accuracy of velocity estimation, the Covariance inverse (CI) based fusion method is applied. A vehicle dynamics model is established and the CI method is analysed. Finally, a joint simulation of CarSim and MATLAB/Simulink is conducted and the results show the advantages of proposed method.
Performance of Active Control and Energy Harvesting of a Novel Suspension System
Authors: Huang Dashan , Zhang Jinqiu , Liu Yile 
Published: May 2020

Abstract
Several processes were employed to improve the defects lie in the existing energy-regenerative suspension, such as the low efficiency of energy harvesting, the lack of unified assessment standards on the performance of energy harvesting. Firstly, a novel suspension system was established with the energy harvesting could also be implemented while controlling, which would improve the efficiency of energy harvesting; Then power flow analysis method was adopted to realize the quantitative analysis on the performance of energy harvesting, 4 evaluation criteria on performance of energy harvesting were established in considering of relative energy-regenerative ability and absolute energy-regenerative ability, which would be used as the unified assessment standards. A LQR controller was presented to control and reduce the vibration of the novel suspension system. To optimize the weight coefficients of LQR active control algorithm, an improved genetic algorithm was designed with 5 improvements on both genetic operator and genetic mechanism. The simulations on the performance of active control of the novel suspension system were preformed, the results show that the riding comfort and handling stability of vehicle are both improved with the genetic-algorithm-optimized LQR controller. The simulations on the performance of energy harvesting of the novel suspension system under different road excitations were conducted, the results show that the assessment standards could represent the energy harvesting ability of suspension system, the novel suspension system provide a better energy harvesting efficiency, the self-powered of suspension system under standard road excitation is realized.