bluuebunny/crossref_metadata_2025_split huggingface dataset:
Product innovation types: a discussion considering building facade products
Authors: Sezegen Aysegul , Edis Ecem 
Published: May 2020

PurposeIn the construction industry, building facade systems are gaining significance as reflected in the number of facade product innovations available on the market. While research studies on the adoption of these facade product innovations are comparatively limited in number. An awareness of the advantages and impacts that a product innovation brings is critical in its adoption, and therefore the purpose of this paper is to develop a classification framework for the use of producers/vendors present the advantages and impacts of their innovative facade products to the architects.Design/methodology/approachThe study, in addition to literature review, consisted of four main steps without distinct boundaries, namely, (1) case study sample selection regarding facade products, (2) data collection through review of published documents, analysis of the data via content analysis and generation of a preliminary framework for the evaluation of facade product innovations, (3) further data collection through semi-structured interviews and analysis of the products and (4) redefining innovation types and finalizing classification framework through assessment of new facade products.FindingsInnovation types may vary according to the product groups under investigation and viewpoints of the classifications. Selected facade products were evaluated in terms of their specific characteristics through identified viewpoints: as a physical object and as an agent. It was revealed that assessing a product innovation in terms of changes in its structural composition and impact on other related physical objects/processes can change the type of innovation. Additionally, insights about improved characteristics specific to facade products, forms of change in these products and architects' new actions in the facade design process were obtained.Research limitations/implicationsOnly the products stated by the producers/vendors as being new to the Turkish market at the time they were introduced were evaluated in terms of all aspects proposed in the framework. For these products and others that were evaluated, the product data obtained from the producers/vendors have been deemed to be accurate. Research on equivalent products in the market has not been conducted.Originality/valueStudies identifying innovation types in the facade industry are very rare. The proposed framework can be regarded as a detailed investigation of product innovation types in the facade industry which offers component-system level improvement/change analysis. Moreover, it can be an effective tool for producers/vendors to ensure that architects have knowledge about their innovative products and their impacts on facade design and also to facilitate the adoption of these products.
Predicting the critical path changes using sensitivity analysis: a delay analysis approach
Authors: Hammad Mohammed , Abbasi Alireza , Chakrabortty Ripon K. , Ryan Michael J. 
Published: May 2020

PurposeThis research presents a framework that allows project managers to predict the next critical paths (CP(s)) and to take extra care when planning and executing those activities that have the potential to cause changes in a project's current CP(s).Design/methodology/approachThe method presented here is based on an assessment of each activity's contribution to the overall schedule variance, which involves assigning a probability distribution function to each activity duration in the project. A sensitivity analysis is also carried out, which forms the basis of identifying which activity most affects the project completion date and therefore will have the greatest effect in changing the CP.FindingsThe authors’ analysis reveals that the most appropriate probability density function (PDF) for the targeted project is the normal distribution. However, the aim of this work is not to determine the most suitable distribution for each activity but rather to study the effect of the activity distribution type on the CP prediction. The results show that the selection of the appropriate probability distribution is very important, since it can impact the CP prediction and estimated project completion date.Originality/valueThis research work proposes a delay analysis scheme which can help the project manager to predict the next CP and to improve performance by identifying which activity is the bottleneck. On the other hand, the simplicity arises from the fact that this method does not require any expensive machines or software to generate results.
Perceived leadership integrity and organisational commitment
Authors: Nangoli Sudi , Muhumuza Benon , Tweyongyere Maureen , Nkurunziza Gideon , Namono Rehema , Ngoma Muhammed , Nalweyiso Grace 
Published: May 2020

PurposeThe purpose of this paper is to investigate the extent to which perceived leadership integrity influences changes in organisational commitment. The premise of the study is the argument that non-financial rewards alleviate the challenges associated with low levels of commitment in economies that are riddled with incessant situations of economic scarcity.Design/methodology/approachAn explanatory study approach was adopted to investigate the envisaged linkage between the study variables from a socio-psychological perspective.FindingsThe results of the study establish that perceived leadership integrity significantly influences variations in commitment among organisational employees.Research limitations/implicationsThe study results provide a reason for firms to invest more resources towards promoting honesty among organisational leaders. The findings of the study support the idea that perceived integrity of an organisation's leadership generates a sustainable win–win position not only between the organisation and employees, but also among the leaders and subordinates.Practical implicationsOrganisations must regularly consider the drivers of organisational commitment and pay sufficient attention to non-financial drivers. As advanced by this study, a very important yet economical way of effecting such a strategy is through instituting measures that sustainably create a perception among employees that organisational leaders execute their duties with the utmost integrity.Originality/valueThis article has both empirical and theoretical value. Empirically, this work is the first of its kind aimed at investigating the effect of perceived leadership integrity on organisational commitment within Uganda's hospitality setting. Theoretically, the study extends the versatility of the hierarchy of needs theory by clarifying that higher-level needs offer a basis for explaining the effect of psychological processes (in this case, perceived leadership integrity) on behavioural changes (in this case, organisational commitment).
The future of your job represents your future: a moderated mediation model of transformational leadership and job crafting
Authors: Naeem Rana Muhammad , Channa Khalil Ahmed , Hameed Zahid , Ali Arain Ghulam , Islam Zia Ul 
Published: May 2020

PurposeIn this study, the authors aim to explain the mechanism between transformational leadership and job crafting. They predict that job-based psychological ownership (job-based PO) mediates the relationship between transformational leadership and job crafting. Furthermore, job-based PO is more effective when employees have a high level of affective organizational commitment.Design/methodology/approachThe authors collected time-lagged data through a paper–pencil survey from the sales department of large pharmaceutical companies in Pakistan.FindingsThe findings of this study suggest that job-based PO mediates the positive relationship between transformational leadership and job crafting. Moreover, the relationship of job-based PO with job crafting is moderated by affective organizational commitment such that the relationship was stronger at the high levels of affective organizational commitment than that of the low levels of affective organizational commitment.Practical implicationsOn practical grounds, job crafting can be useful for individuals and organizations. On individuals’ side, it helps them to balance their job demands and resource; on organizations’ side, it provides a solution to the ongoing problem of disengaged employees and suggests managers identify new ways to support employees with their job redesign.Originality/valueThis study suggests that job-based PO and affective organizational commitment are important factors that influence the relationship between transformational leadership and job crafting.
Tree diversity effects through a temporal lens: Implications for the abundance, diversity and stability of foraging birds
Authors: May‐Uc Yanely , Nell Colleen S. , Parra‐Tabla Víctor , Navarro Jorge , Abdala‐Roberts Luis 
Published: May 2020

Abstract

Tree diversity exerts a strong influence on consumer communities, but most work has involved single time point measurements over short time periods. Describing temporal variation associated with diversity effects over longer time periods is necessary to fully understand the effects of tree diversity on ecological function.

We conducted a year‐long study in an experimental system in southern Mexico assessing the effects of tree diversity on the abundance and diversity of foraging birds. To this end, we recorded bird visitation patterns in 32 tree plots (21 × 21 m; 12 tree species monocultures, 20 four‐species polycultures) every 45 days (n = 8 surveys) and for each plot estimated bird abundance, richness, functional diversity (FD) and phylogenetic diversity (PD). In each case, we reported temporal (intra‐annual) variation in the magnitude of tree diversity effects, and calculated the temporal stability of these bird responses.

Across surveys, tree diversity noticeably affected bird responses, demonstrated by significantly higher abundance (43%), richness (32%), PD (25%) and FD (25%) of birds visiting polyculture plots compared to monoculture plots, as well as a distinct species composition between plot types. We also found intra‐annual variation in tree diversity effects on these response variables, ranging from surveys for which the diversity effect was not significant to surveys where a significant 80% increase (e.g. for bird FD and PD) was observed in polyculture relative to monoculture plots. Notably, tree diversity increased the stability of all bird responses, with polycultures having a greater stability abundance (18%), richness (38%), PD (32%), and FD (35%) of birds visiting tree species polycultures compared to monocultures.

These results show that tree diversity not only increases bird visitation to plots, but also stabilizes bird habitat usage over time in ways that could implicate insurance‐related mechanisms. Such findings are highly relevant for understanding the long‐term effects of plant diversity on vertebrates and the persistence of bird‐related ecosystem functions. More work is needed to unveil the ecological mechanisms behind temporal variation in vertebrate responses to tree diversity and their consequences for community structure and function.
Climate change and vessel traffic create networks of invasion in marine protected areas
Authors: Iacarella Josephine C. , Lyons Devin A. , Burke Lily , Davidson Ian C. , Therriault Thomas W. , Dunham Anya , DiBacco Claudio 
Published: May 2020

Abstract

Establishment of protected areas to maintain biodiversity requires identification, prioritization and management of stressors that may undermine conservation goals. Nonindigenous species and climate change are critical ecosystem stressors that need greater attention in the context of spatial planning and management of protected areas. Risk of invasion into protected areas needs to be quantified under current and projected climate conditions in conjunction with prioritization of key vectors and vulnerable areas to enable development of effective management strategies.

We assessed the likelihood of invasion across networks of marine protected areas (MPAs) to determine how invaded MPAs may compromise MPA networks by sharing nonindigenous species. We evaluated invasion risk in 83 MPAs along Canada's Pacific coast for eight nonindigenous species based on environmental suitability under current and future (average conditions from 2041 to 2070) climate conditions and association with shipping and boating pathways. We applied species distribution models and network analysis of vessel tracking data for 805 vessels in 2016 that connected MPAs.

The probability of occurrence within MPAs and the proportion of MPA area that is suitable to the modelled species significantly increased under future climate conditions, with six species reaching over 90% predicted occurrence across MPAs and over 70% of suitable area within MPAs. Vessel traffic created four network clusters of 61 highly connected MPAs that spanned the coastline. Occupancy of over 90% of the MPAs within the clusters was predicted for most species.

Synthesis and applications. Our results indicate a high likelihood of marine protected area (MPA) network invasion based on current and future environmental conditions and vectors of spread, and the potential for extensive nonindigenous species distributions within MPAs. Our approach highlights how interacting stressors can exacerbate MPA susceptibility to nonindigenous species, adding further challenges for protected area management. Management planning that invests in understanding connectivity and vector processes (human behaviours) is more likely to derive effective policies to stem the flow of nonindigenous species under both current and future conditions. In particular, biosecurity measures including vessel biofouling regulations and MPA‐ and MPA network‐specific plans for prevention, monitoring and mitigation of nonindigenous species are needed.
Use of computed tomography and magnetic resonance imaging for occult neck of femur fractures: A single‐centre study
Authors: Kutaiba Numan , Lamanna Anthony , Malara Frank , Yap Lee‐Pheng 
Published: May 2020

AbstractObjectiveNeck of femur (NOF) fractures are common and serious injuries in the elderly. When a NOF fracture is suspected but is not clearly visible on radiographs, guidelines recommend magnetic resonance imaging (MRI), or computed tomography (CT) if MRI is not available/contraindicated. The aim of our study was to review the use of CT and subsequent MRI for suspected NOF fractures in patients with negative or equivocal radiographs.MethodsA retrospective review of adult patients with negative or equivocal plain radiographs with suspected NOF fractures presenting between 1 July 2015 and 30 June 2017 was performed. Review of CT and subsequent MRI studies was performed with documentation of reported findings, time intervals from plain radiographs to CT and MRI and final outcomes.ResultsA total of 184 CT studies in 181 patients were reviewed; median age was 82 years (interquartile range 71–89 years) with 110 (60.8%) female patients. CT reported 20 occult fractures; all proceeded to surgery. MRI was performed in 23 patients and revealed additional four NOF fractures missed by CT. An additional fifth fracture missed by CT was confirmed by follow‐up radiographs. Median time was approximately 4 h from radiographs to CT and approximately 56 h from radiographs to MRI.ConclusionAccess to CT for evaluation of suspected occult NOF fractures is much quicker compared to MRI. When CT results are negative with on‐going clinical suspicion of an occult fracture, MRI should be performed in a time efficient manner.
Today's protected areas: supporting a more sustainable future for humanity
Authors: MCNEELY Jeffrey A. 
Published: May 2020

AbstractNature provides significant benefits to people, especially those living in and around protected areas. Ecosystem services from protected areas include producing wild food, supporting biodiversity and water cycles, regulating climate, and providing cultural services like better health, tourism, and legacy for future generations. In economic terms, the flows of ecosystem services provided by protected areas are worth hundreds of billions of dollars each year, well justifying the costs of managing these sites, but protected areas are suffering from environmental problems such as impacts from human population growth, rural poverty, growing demands for natural resources, land use change that degrades ecosystem productivity, invasive non‐native species that harm natural ecosystems, and climate change that is affecting all ecosystems. Addressing these linked challenges will require mobilizing all parts of the economy, including the protected area estate. For example, protected areas can take a leadership role in rural development, expand the conservation estate to half of the planet through connectivity and improved management of more of the non‐agricultural land, enhance the prominent role of protected areas in contributing to climate change mitigation and adaptation, encourage productive research on applying modern technology to protected areas management, seek broader private sector participation in conserving biodiversity and ecosystem services, and include protected areas as relevant parties in relevant trade and other international negotiations. When protected area managers embrace this broader role, they will find enthusiastic public support for this contribution to a sustainable human society.
The unicellular eukaryotic parasite Toxoplasma gondii hijacks the migration machinery of mononuclear phagocytes to promote its dissemination
Authors: Ólafsson Einar B. , Barragan Antonio 
Published: May 2020

AbstractToxoplasma gondii is an obligate intracellular protozoan with the ability to infect virtually any type of nucleated cell in warm‐blooded vertebrates including humans. Toxoplasma gondii invades immune cells, which the parasite employs as shuttles for dissemination by a Trojan horse mechanism. Recent findings are starting to unveil how this parasite orchestrates the subversion of the migratory functions of parasitised mononuclear phagocytes, especially dendritic cells (DCs) and monocytes. Here, we focus on how T. gondii impacts host cell signalling that regulates leukocyte motility and systemic migration in tissues. Shortly after active parasite invasion, DCs undergo mesenchymal‐to‐amoeboid transition and adopt a high‐speed amoeboid mode of motility. To trigger migratory activation – termed hypermigratory phenotype – T. gondii induces GABAergic signalling, which results in calcium fluxes mediated by voltage‐gated calcium channels in parasitised DCs and brain microglia. Additionally, a TIMP‐1‐CD63‐ITGB1‐FAK signalling axis and signalling via the receptor tyrosine kinase MET promotes sustained hypermigration of parasitised DCs. Recent reports show that the activated signalling pathways converge on the small GTPase Ras to activate the MAPK Erk signalling cascade, a central regulator of cell motility. To date, three T. gondii‐derived putative effector molecules have been linked to hypermigration: Tg14‐3‐3, TgWIP and ROP17. Here, we discuss their impact on the hypermigratory phenotype of phagocytes. Altogether, the emerging concept suggests that T. gondii induces metastasis‐like migratory properties in parasitised mononuclear phagocytes to promote infection‐related dissemination.
A rational roadmap for SARS‐CoV‐2/COVID‐19 pharmacotherapeutic research and development: IUPHAR Review 29
Authors: Alexander Steve P.H. , Armstrong Jane F. , Davenport Anthony P. , Davies Jamie A. , Faccenda Elena , Harding Simon D. , Levi‐Schaffer Francesca , Maguire Janet J. , Pawson Adam J. , Southan Christopher , Spedding Michael 
Published: May 2020

In this review, we identify opportunities for drug discovery in the treatment of COVID‐19 and, in so doing, provide a rational roadmap whereby pharmacology and pharmacologists can mitigate against the global pandemic. We assess the scope for targeting key host and viral targets in the mid‐term, by first screening these targets against drugs already licensed, an agenda for drug repurposing, which should allow rapid translation to clinical trials. A simultaneous, multi‐pronged approach using conventional drug discovery methods aimed at discovering novel chemical and biological means of targeting a short list of host and viral entities which should extend the arsenal of anti‐SARS‐CoV‐2 agents. This longer term strategy would provide a deeper pool of drug choices for future‐proofing against acquired drug resistance. Second, there will be further viral threats, which will inevitably evade existing vaccines. This will require a coherent therapeutic strategy which pharmacology and pharmacologists are best placed to provide.LINKED ARTICLESThis article is part of a themed issue on The Pharmacology of COVID‐19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc
Causes of death in patients diagnosed with gastric adenocarcinoma in Sweden, 1970‐2014: A population‐based study
Authors: Xie Shao‐Hua , Chen Hai , Lagergren Jesper 
Published: May 2020

AbstractThe causes of death in patients with gastric adenocarcinoma have not been well characterized. This nationwide population‐based cohort study included 56 240 patients diagnosed with gastric adenocarcinoma in 1970‐2014 in Sweden. We used competing‐risks regression to compare cause‐specific risks of death in patients with different characteristics and a multiple‐cause approach to assess proportions of deaths attributable to each cause. Among 53 049 deaths, gastric cancer was the main (77.7% of all deaths) underlying cause. Other major underlying causes were nongastric malignancies (8.0%), ischemic heart disease or cerebrovascular disease (6.5%), and respiratory diseases (1.4%). Risk of death from gastric cancer steadily decreased in patients with cardia adenocarcinoma over the study period, but remained relatively stable in patients with noncardia adenocarcinoma since the 1980s. Risk of death from other malignancies increased during later calendar periods (subhazard ratio [SHR] = 2.16, 95% confidence interval [CI] 1.97‐2.38, comparing 2001‐2014 with 1970‐1980). Compared with men, the risk of death in women with cardia adenocarcinoma was higher from gastric cancer (SHR = 1.18, 95% CI 1.10‐1.27), but lower from other malignancies (SHR = 0.80, 95% CI 0.71‐0.91). In multiple‐cause models, 60.4%‐71.2% of all deaths were attributable to gastric cancer and 9.5%‐12.1% to other malignancies. The temporal trends of cause‐specific risks from multiple‐cause models were similar to those of underlying causes. Our findings suggest that although most deaths in patients with gastric adenocarcinoma are due to gastric cancer, other causes of death are common. Patients with cardia adenocarcinoma face considerable increasing risk of death from other causes over time, particularly from other malignancies.