bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of a visual indicator on the noise level in an emergency medical dispatch center - a pilot study
Authors: Outrey Justin , Pretalli Jean-Baptiste , Pujol Sophie , Brembilla Alice , Desmettre Thibaut , Lambert Christophe , Labourey Jean-Marc , Mauny Frédéric , Khoury Abdo 
Published: October 2020

Abstract
Background A maximum of 52 to 55 dB(A) is recommended in order to prevent adverse events in call centres. We aimed at assessing the noise level and the impact of a visual noise indicator on the ambient noise level in a French Regional Emergency Medical Dispatch Centre (EMDC). Methods We conducted an observational study in the EMDC of the SAMU25 (University Hospital of Besancon). We measured the noise level using a SoundEarII® noise indicator (Dräger Medical SAS, France). The measurement took place in two phases on three consecutive days from 00:00 to 11:59 PM. At baseline, phase 1, the device recorded the average ambient noise for each minute without visual indication. Secondly, phase 2 included a sensor mounted with a light that would turn on if noise ever exceeded 65 and 75 dB(A). Results The sound level was greater than 52 dB(A) in 97.2% and 66.8% of the time in phases 1 and 2 respectively; this level was greater than 55 dB(A) in 84.9% and 43.9% of the time in phases 1 and 2 respectively.Conclusions The noise levels were higher than recommended and sometimes close to legal limits, requiring preventive measures. The noise indicator had a positive effect on the ambient noise level. This work will allow the implementation of effective prevention solutions and, based on future assessments, could improve operators’ well-being and better care for patient.
Characterization of Confirmed and Suspected COVID-19 Pneumonia Patients in a Retrospective Cohort Study in Wuhan
Authors: Xi Maomao , Cui Dan , Liu Qiaomei , Li Lili , Yin Yilin , Dong Fang , Xiong Di , Wu Yuwei , Guo Hongrong , Bao Min , Li Zhanghua , Luo Man , Wu Juan , Xie Weiguo , Wu Qingming , Peng Anlin , Wu Jinhu , Tan Yiqing , Sun Jianbin , Luo Pengcheng , Huang Zan , Huang Xiaodong 
Published: October 2020

Abstract
Background: A methodical comparison of confirmed and suspected COVID-19 patients has not been previously reported. Therefore, we thoroughly analyzed the demographic and clinical characteristics between these groups to identify mortality risk factors.Methods: A retrospective cohort of 1,276 hospitalized COVID-19 pneumonia patients at Tongren Hospital (Wuhan, China; January 27 to March 3, 2020) was studied. Cox regression analyses were performed to evaluate multiple mortality risk factors. Results: Both cohorts of confirmed (n=797) and suspected (n=479) patients exhibited typical demographic, clinical, and radiological characteristics. Treatment methods were consistent and both groups shared similarities in many demographic and clinical characteristics: age (≥65, 45.9% vs 41.8%, P=0.378) and lung disease (12.5% vs 14.6%, P=0.293). However, confirmed patients exhibited more severe disease manifestations than those in suspected patients: a higher incidence of fever (65.4% vs 58.0%, P<0.01), lower lymphocyte count (1.12×109/L vs 1.22×109/L, P=0.022), higher C-reactive protein (CRP) (11.60 mg/L vs 7.61mg/L, P=0.021), and more severe radiographic manifestations (lung infection incidence, 3.8% vs 3.0%, P=0.014; ground-glass opacity lesion incidence, 2.3% vs 2.0%, P=0.033). The dynamic profiles of lymphocytes, monocytes, D-dimer, and CRP, clearly delineated confirmed patients from suspected patients exhibiting critical illness. Cox regression analysis demonstrated that lung disease (adjusted hazard ratio 8.972, 95% CI: 3.782-21.283), cardiovascular disease (3.083, 1.347-7.059), neutrophil count (1.189, 1.081-1.307), age (1.068, 1.027-1.110), and ground-glass opacity lesions (1.039, 95% 1.013-1.065), were the main risk factors for mortality in confirmed patients; lung disease (14.725, 2.187-99.147), age (1.076, 1.004-1.153), and CRP level (1.012, 95% CI 1.004-1.020) were the primary factors in suspected patients.Conclusions: Suspected patients with serious illness should seek medical attention to reduce mortality. Multiple factors must be assessed to determine the mortality risk and the appropriate treatment.
Butyrophilin-like 9 regulates immune infiltration and serves as a prognostic marker in lung adenocarcinoma
Authors: Ma Weishuang , Liang Jiaming , Zhang Siyuan , Ningdong Hu , Chen Zisheng , Tian Dongbo 
Published: October 2020

Abstract
Background: Butyrophilin (BTN) and butyrophilin-like (BTLN) belong to immunoglobulin superfamily, and also pertain the B7 co-stimulatory molecules family, which has multiple roles in immune modulation. Whether the BTNL9 expression in lung adenocarcinoma (LUAD) correlates with outcome has not been evaluated.Materials and methods: Oncomine and GEPIA were used to analyze the BTNL9, while its mRNA expression in LUAD and corresponding adjacent tissues was investigated using TIMER. The clinical prognosis of BTNL9 was assessed in the GEPIA, Kaplan-Meier plotter, and OncoLnc. Besides, the correlation between BTNL9 and tumor-infiltrating immune cells (TILs) was analyzed using TIMER and GEPIA. The correlation between BTNL9 expression and drug response was analyzed using CARE.Results: BNL9 expression was significantly low in LUAD. Low BTNL9 expression was associated with poor OS, and its expression was found to be regulated by both epigenetic regulation and post-transcriptional modification. BTNL9 expression was significant positively correlated with ImmuneScore and ESTIMATEScore. Moreover, BTNL9 expression was positively correlated with infiltrating levels of B cells, CD4+T, and macrophages, but Kaplan-Meier analysis showed that BTNL9 expression in B cells and DCs was significantly associated with OS. Furthermore, BTNL9 expression has significant positive CARE scores. Conclusions: Low BTNL9 expression can prevent the infiltration of naïve B cells and DCs in the tumor microenvironment and worsen the outcome in LUAD patients. Besides, these findings also suggest the potential role of BTNL9 as a prognostic biomarker and a new immuno-target.
Risk of hepatitis B virus reactivation in hepatitis B surface antigen-negative patients with solid tumors who received systemic chemotherapy: two retrospective studies
Authors: Kuroda Junko , Kusumoto Shigeru , Kimata Tsukasa , Kataoka Tomomi , Hibi Satoshi , Nakane Shigeki , Choshi Masakazu , Tashiro Yuusuke , Takemoto Masashi , Tanaka Yasuhito , Komatsu Hirokazu , Kawada Kenji , Muro Kei , Kimura Kazunori 
Published: October 2020

Abstract
Background: There is little evidence regarding the risk of hepatitis B virus (HBV) reactivation in solid tumor patients without hepatitis B surface antigen (HBsAg), but with antibodies against hepatitis B core antigen (anti-HBc) and/or antibodies against HBsAg (anti-HBs) who received systemic chemotherapy. Methods: We conducted two retrospective studies; a single-center retrospective study to measure the incidence of HBV reactivation in 1,376 HBsAg-negative patients with solid tumors who received systemic chemotherapy, and a multicenter retrospective study to clarify the clinical features of HBV reactivation in HBsAg-negative patients with solid tumors who received systemic chemotherapy at 5 institutions. HBV reactivation was defined as reappearance of HBsAg or detection of HBV DNA levels of 1.3 log IU/mL or more in both studies.Results: With a median follow-up time of 607 days, HBV reactivation was confirmed in 2 of 218 patients with resolved HBV infection in the single-center study. Of the 12 patients with HBV reactivation who were diagnosed at a median HBV DNA of 1.3 log IU/mL in the multicenter study, no HBV-related hepatitis was observed. The median time from the first chemotherapy to confirmed HBV reactivation was 141 days. Of the 11 patients in whom both anti-HBc and anti-HBs were measured, all were seropositive for anti-HBc, and 7 were seronegative for anti-HBs at baseline.Conclusions: The risk of HBV reactivation was estimated to be 0.9% in HBsAg-negative patients with solid tumors who received systemic chemotherapy. Seronegativity for anti-HBs at baseline may be an important risk factor for HBV reactivation in these patients.
The prevalence of HEV among non-A-C hepatitis in Qatar and efficiency of serological markers for the diagnosis of hepatitis E
Authors: Absi Enas S. Al , Al-Sadeq Duaa W. , Khalili Makiyeh , Younes Nadin , Al-Dewik Nader , Abdelghany Sara K. , Abouzid Somaia S. , Thani Asma A. Al , Yassine Hadi. M. , Coyl Peter , Nasrallah Gheyath 
Published: October 2020

Abstract
BackgroundThe rapid growth of Qatar in the last two decades has attracted a large influx of immigrant workers who mostly come from HEV-hyperendemic countries. Thus, we aim to investigate the prevalence of HEV among acute non-A-C hepatitis patients in Qatar; and to evaluate the performance of four dominant commercial serological assays for HEV diagnosis.Methods259 patients with non-A-C hepatitis were tested using the Wantai HEV-IgM, HEV-IgG, HEV-Ag ELISA kits, and the MP Biomedical HEV-Total Ab ELISA kit. ALT levels were tested and HEV RNA (viral loads) was performed using Taqman RT-PCR kit. The performance of each kit was assessed according to the RT-PCR results. ResultsHEV-RNA was detected in 23.1% of the samples. Most of these HEV-RNA-positive cases belonged to non-Qatari residents from the Indian subcontinent; India, Pakistan, etc. HEV-Ag, HEV-IgM, HEV-IgG, HEV-Total Ab was detected in 5.56%, 8.65%, 32.1%, and 34.2% of all tested samples, respectively. Elevated ALT level correlated highly with the HEV-Ag, HEV-RNA, HEV-IgM, but not with the HEV-IgG and HEV-Total Ab. Although HEV-Ag was very specific (100%), yet its sensitivity was poor (36.7%). HEV-IgM demonstrated the best second marker for diagnosis of acute HEV after RT-PCR as jugged by the overall performance parameters: specificity (96.2%), sensitivity (71.43%), PPV (83.3%), NPP (92.7%), agreement with RT-PCR (91.0%), and Kappa-value (0.71).ConclusionOur study demonstrated high prevalence of HEV virus in Qatar, mostly among immigrants from the Indian subcontinent. The HEV-IgM represents the best marker for the detection of the acute HEV infection, where RT-PCR cannot be performed.
Dynamical analysis of the global elevational diversity gradient in passerine birds reveals a prominent role for highlands as species pumps
Authors: Els Paul van , Herrera-Alsina Leonel , Pigot Alex L. , Etienne Rampal 
Published: October 2020

Abstract
Low elevation regions harbor the majority of the world’s species diversity compared to high elevation areas. This global elevational diversity gradient, suggests that lowland species have had more time to diversify, or that net diversification rates have been higher in the lowlands (either due to higher ecological limits or intrinsically higher diversification rates). However, highlands seem to be cradles of diversity as they contain many young endemics, suggesting that their rates of speciation are exceptionally fast. Here, we use a phylogenetic diversification model that accounts for the dispersal of species between different elevations to examine the evolutionary dynamics of the elevational diversity gradient in passerine birds, a group that has radiated globally to occupy almost all elevations and latitudes. We find strong support for a model where passerines diversify at the same rate in the highlands and the lowlands but where the rate of dispersal from high to low elevations is more than twice as fast as in the reverse direction. This suggests that while there is no consistent trend in diversification across elevations, highland regions act as species pumps because the diversity they generate migrates into the lowlands, thus setting up the observed gradient in passerine diversity. This species pump is particularly strong in the tropics, where the inferred rate of speciation is 1.4 times faster than in the temperate zone. We conclude that despite their lower diversity, highland regions are disproportionally important for maintaining diversity in the adjacent lowlands. The extinction of species in the tropical highlands due to rapid climate change this century could thus have major and long-lasting impacts on global passerine diversity.
Resilience, Self-Perceived Burden, Social Support and Their Correlation in&nbsp;Cancer Patients – A Cross-Sectional Study in China
Authors: Yu Zhifu , Zuo Tingting , Jiang Guichun , Zhang Qiang , Jiang Shuang , Xing Haiyang , Cao Li , Cai Lijuan , Liu Jihong , Liu Yunyong 
Published: October 2020

Abstract
Objective: The aim of this study was to explore resilience, self-perceived burden, social support and their correlation in patients with malignant tumors and provide evidence for clinical intervention.Methods: A multi-center cross-sectional study was performed in China. All the participants completed a questionnaire including sociodemographic information. Resilience, patients’ perceptions of burden on their caregivers and the level of social support were evaluated. Results: A total of 439 cancer patients were analyzed in our study. The level of resilience differed significantly by education grade, employment status, insurance type, household income per year, and treatment type. Patients with no job, rural residents, those with lower household income and those holding new rural cooperative medical scheme (NRCMS) insurance had higher SPB score, with statistical significance. Patients who underwent higher education, those with a full-time job, were married, with higher household income and urban employee's basic medical insurance (UEBMI) had higher social support. Social support was found to be highly related to resilience. Resilience was negatively correlated with emotional burden, and the emotional and physical burden and social support strongly influenced resilience. Path analysis found that social support played an intermediary role in the process of SPB affecting resilience.Conclusion: The resilience status of cancer patients was low and was affected by the self-burden level through social support. The study reminded us that improving the resilience level by education to improve the social support of cancer patients will improve the quality of life patients.
Total Joint Arthroplasty Has Better Safety and Outcomes in Renal Transplant Patients Than in Dialysis Patients—A Meta-Analysis and Systematic Review
Authors: Li Jiayi , Li Mingyang , Peng Bo-qing , Luo Rong , Chen Quan , Huang Xin 
Published: October 2020

Abstract
Objectives End-stage renal disease (ESRD) patients are at an increased risk of needing total joint arthroplasty (TJA); however, both dialysis and renal transplantation might be potential predictors of adverse TJA outcomes. For dialysis patients, the high risk of blood-borne infection and impaired muscular-skeletal function are threats to the survival of implants, while, for renal transplant patients, immunosuppression therapy is also a concern. There is still no high-level evidence in the published literature that has determined the best timing of TJA for ESRD patients. Methods A literature search in MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials (up to November 2019) was performed to collect studies that compared TJA outcomes between renal transplant patients and dialysis patients. Literature screening and quality assessments with the Newcastle-Ottawa scale (NOS) were conducted by two reviewers. After the data were extracted, statistical analyses were performed.Results Compared with the dialysis group, a lower risk of mortality (RR=0.56, Cl= [0.42, 0.73], P<0.01, I2=49%) and revision (RR =0.42, CI = [0.30, 0.59], P < 0.01, I2=43%) was detected in the renal transplant group. Different results of periprosthetic joint infection were shown in subgroups with different sample sizes. There was no significant difference in periprosthetic joint infection in the small-sample-size subgroup, while in the large-sample-size subgroup, renal transplant patients had significantly less risk (RR =0.19, CI = [0.13, 0.23], P < 0.01, I2=0%). For dislocation, venous thromboembolic disease, and overall complications, there was no significant difference between the two groups. Conclusion Total joint arthroplasty has better safety and outcomes in renal transplant patients than in dialysis patients. Therefore, delaying total joint arthroplasty in dialysis patients until renal transplantation has been performed would be a desirable option. The controversy among different studies might be partially accounted for that quite a few studies have a qiute small sample size to detect the difference between renal transplant patients and dialysis patients.
WITHDRAWN: Efficacy of Chinese Herbal Formulation Combined With Bone Mesenchymal Stem Cells in Repairing Rat Cartilage Tissues
Authors: Wang Haidong , Wu Chengjun , Yao Xiaodong 
Published: October 2020

Abstract
Background: cartilage damage is a chronic disease that affecting most aging population, and the effects of Chinese herbal formulation combined with bone mesenchymal stem cells (BMSCs) in repairing rat cartilage tissues were tested. Methods: Forty SD rats were randomly divided into group A, B, C and D groups (n=10). A cartilage tissue injury models by surgical drilling was made in rats. The histological and morphological changes of cartilage tissues in each group were evaluated through H&E staining and pathological Mankin scores were also analyzed. Results: our data showed that the combination of herbal formulation and BMSCs implanted 3D bioscaffold can produce most ideal therapeutic effect to repair the damaged cartilage tissue. Mankin scores were significantly decreased at 8 weeks after surgery in each group (P < 0.05). The load-displacement, stress-strain, elastic modulus, and relative expression levels of type II collagen and proteoglycan were significantly increased (P<0.05) in groups D compared to other groups. Conclusion: our data provides novel insights of Chinese herbal formulation combined implanted BMSCs with 3D biological scaffold to improve the repair of damaged knee injury in rats, which demonstrated a promising avenue to treat damaged cartilage in the clinic.
Comparative Study of Imaging Parameters between a New Cervical Full Lamina Back Shift Spinal Canal Enlargement Technique and Single Open-door Laminoplasty for Multisegment Cervical Spondylotic Myelopathy
Authors: Wang Xiaonan , Zhao Yibo , Lu Xiangdong , Zhao Xiaofeng , Qi Detai , Wang Wenxuan , Zhou Runtian , Jin Yuanzhang , Fan Zhifeng , Zhao Bin 
Published: October 2020

Abstract
Purpose To provide imaging evidence of the feasibility and clinical efficacy of a new full lamina back shift spinal canal enlargement technique by comparing its imaging parameters to those of single open-door miniature titanium plate internal fixation.Methods A retrospective analysis was conducted on 64 patients with multisegment cervical spondylotic myelopathy caused by cervical stenosis. Of these, 32 underwent the new full lamina back shift spinal canal enlargement technique (observation group), and 32 underwent single open-door miniature titanium plate internal fixation (control group). The CT data of both groups were imported into Mimics 17.0 software to measure the median sagittal diameter and cross-sectional area of the spinal canal. Photoshop CS5 was employed to measure the drift distance of the spinal cord on MR images to perform a comparative study of the imaging parameters from the two groups.Results The T2-weighted MR images in both groups showed continuous recovery of the cerebrospinal fluid signal in the C3–C7 range. The new full lamina back shift spinal canal enlargement technique was significantly superior to single open-door miniature titanium plate internal fixation with respect to the spinal canal cross-sectional area and the median sagittal diameter (P<0.05). No significant difference was detected in the drift distance of the spinal cord between the two groups (P>0.05).Conclusion The new full lamina back shift spinal canal enlargement technique achieved a thorough spinal canal decompression effect on imaging while ensuring a reasonable spinal drift distance and few surgical complications. The clinical curative effect of the new technique was precise.
Optimizing the use of Cesarean Section in Argentina: Design and Methodology of a Formative Research for the Development of Interventions
Authors: Ramos Silvina , Romero Mariana , Perrotta Carla , Sguassero Yanina , Straw Cecilia , Gialdini Celina , Righetti Natalia , Betran Ana Pilar 
Published: October 2020

Abstract
Background: The sustained increase of cesarean sections constitutes a global problem. The purpose of this formative research is to collect information from hospitals, health professionals and women as regards the use of cesarean section in Argentina. This article describes the methodology of the study, the characteristics of the hospitals and the profile of the participants. Methods: Transversal study to be conducted in seven provinces of Argentina. The eligibility criteria for the hospitals are a) use of the Perinatal Computer System, b) cesarean section rate higher than 27% in 2016, c) ≥1000 deliveries per year. Quantitative and qualitative research techniques are used for data collection and analysis. The main inquiry points are the following: determining factors for the use of cesarean section, potential interventions to optimize the use of cesarean section and, in the case of women, preferred type of delivery. Discussion: It is expected that the findings will make it possible to obtain a situation diagnosis to help in a context-sensitive implementation of the interventions recommended by the World Health Organization to optimize cesarean section use.Trial registration: IS002316
Effect of Broussonetia papyrifera Silage on the Serum Indicators, Hindgut Parameters and Fecal Bacterial Community of Holstein Heifers
Authors: Tian Hanchen , Chen Yiye , Zhu Ni , Guo Yongqing , Deng Ming , Liu Guangbin , Li Yaokun , Liu Dewu , Sun Baoli 
Published: October 2020

Abstract
This study investigated the effects of substitution of whole corn silage (CS) with Broussonetia papyrifera silage (BPS) in different ratios on the serum indicators, hindgut fermentation parameters (pH, ammoniacal nitrogen, and volatile fatty acids), and fecal bacterial community of Holstein heifers. Sixteen heifers (8-month-old, 220±30 kg) were randomly divided into four treatments according to different BPS substitution ratios of feed basis (0%, 25%, 50%, and 75%). The experiment consisted of a 7-day preliminary feeding period and a 30-day experimental period. On the last day of the trial, the blood samples were collected from caudal vein, and the feces samples were collected from rectum. With the increasing of BPS content, the concentration of malondialdehyde (MDA) and interleukin-1β (IL-1β) in serum decreased (P<0.05), and the immunoglobulin A (IgA) and IL-4 content of serum increased (P<0.05); and the hindgut pH value increased (P<0.05). 16S rDNA sequencing found that the dominant phyla were Firmicutes, Bacteroidetes, and Verrucomicrobia; and the dominant genera were Ruminococcaceae_UCG-005, Ruminococcaceae_UCG-010, and Rikenellaceae_RC9_gut_group. Linear Discriminant Analysis Effect Size (LEfSe) analysis found 12 differential operational taxonomic units (OTUs) which have strong correlation with some serum and hindgut indicators. Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) found that BPS have impacts on the pathways, such as carbohydrate transport and metabolism, and promotes amino acid transport and metabolism. To sum up, inclusion of BPS in heifer diets can affect the fecal bacterial community, and further improve serum anti-oxidant and immune indicators in Holstein heifers.