bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation on an application of emergency rescue in the initial natural earthquake by wavelet analysis
Authors: Peng Majun , Wei Cheng 
Published: May 2020

Abstract
Earthquake brings great harm to humans. In order to achieve the desired effect and mitigation effectiveness of early warning, it must reduce the time of rapidly assessing earthquake location and processing seismic and other data. Seismic phase identification based on the wavelet analysis is a powerful and widely spread method in identifying the initial earthquakes. We can get the signals’ recognition factor of S wave and P wave in different scale. Then according to these recognition factors, we can determine the positioning function of primary earthquake of S wave and P wave. Next through the positioning function, we can easily pick up the first arrival of P wave and S wave. The wavelet packet analysis is a more precise analysis method of signal, which makes the frequency band multi-level division, and further decomposes the high-frequency part. Also, the wavelet analysis does not subdivide, and according to the characteristics of analysis-signal, the adaptive-select the corresponding frequency band is matched by the frequency spectrum of the signal, improving the time-frequency resolution. This paper mainly investigated the applications of initial earthquakes identification on emergency rescue, and it can be a useful theoretical reference for further relevant research.
An In Silico Exploration of the Factors That Affect the Precision of the Bethesda Assay
Authors: Seheult Jansen N , Cardel Laynalee , Tange Julie I , Ashrani Aneel , Nichols William L , Heikal Nahla , Chen Dong 
Published: May 2020

Abstract

Objectives
Despite more than 40 years of experience performing the Bethesda assay (BA), poor intra- and interlaboratory precision remains the biggest laboratory challenge to date.

Methods
The BA procedure was modeled using stochastic simulation techniques to determine the precision of the BA up to dilutions of 1:4,096, to estimate the minimum significant relative change at various inhibitor titers, and to understand the laboratory procedural variables that could significantly affect the performance of the BA at high dilutions.

Results
Selecting the lowest dilution tube with a residual activity closest to 25% for calculating the reported Bethesda titer (BT), using a factor activity assay with a coefficient of variation less than or equal to 7.5% in the range of 15% to 50% factor activity level, performing the factor activity measurement in replicates, and minimizing pipette volumetric error resulted in the lowest imprecision in the reported BT. The factor neutralization kinetics of the inhibitor appear to have little impact on the precision of the assay if the incubation time is greater than 90 minutes.

Conclusions
This in silico model will assist future laboratory efforts in standardizing the quantification of specific coagulation factor inhibitors and improving the precision of the reported results.
The Concept of Disorder Revisited: Robustly Value-Laden Despite Change
Authors: Cooper I—Rachel 
Published: May 2020

AbstractOur concept of disorder is changing. This causes problems for projects of descriptive conceptual analysis. Conceptual change means that a criterion that was necessary for a condition to be a disorder at one time may cease to be necessary a relatively short time later. Nevertheless, some conceptually based claims will be fairly robust. In particular, the claim that no adequate account of disorder can appeal only to biological facts can be maintained for the foreseeable future. This is because our current concept of disorder continues to be laden with ethical and political values in multiple ways.
The making of a category of economic understanding in Great Britain (1880–1931): ‘the unemployed’
Authors: Lagneau-Ymonet Paul , Reynaud Bénédicte 
Published: May 2020

Abstract
Evidence-based policy relies on measurement to trigger actions and to manage and evaluate programmes. Yet measurement requires classification: the making of categories of understanding that approximate or represent collective phenomena. In 1931, two decades after implementing the first compulsory unemployment benefits in 1911, the British Government began to carry out a census of out-of-work individuals. Why such an inversion, at odds with the exercise of rational-legal authority, and unlike to its French or German counterparts? To solve this puzzle, we document the making of ‘the unemployed’ as a category of scientific analysis and of public policy in nineteenth-century Great Britain. Our circumscribed contribution to the history of economic thought and methodology informs today’s controversies on the future of work, the weakening of wage labour through the rise in the number of part-time contracts and self-employed workers, as well as the rivalry between the welfare state and private charities with regard to providing impoverished people with some kind of relief.
Pregnancies in kidney transplant recipients with complement gene variant-mediated thrombotic microangiopathy
Authors: Haninger-Vacariu Natalja , Aigner Christof , Gaggl Martina , Kain Renate , Prohászka Zoltán , Böhmig Georg A , Sunder-Plassmann Raute , Sunder-Plassmann Gere , Schmidt Alice 
Published: May 2020

Abstract

Background
Pregnancies in patients with complement gene variant-mediated thrombotic microangiopathy (cTMA) are challenging, and pregnancies in such patients after kidney transplantation (KTX) are even more so.

Methods
We identified nine pregnancies following KTX of three genetically high-risk cTMA patients enrolled in the Vienna thrombotic microangiopathy cohort. Preventive plasma therapy was used in three pregnancies, and one patient had ongoing eculizumab (ECU) therapy during two pregnancies.

Results
Seven out of nine pregnancies (78%) resulted in the delivery of healthy children. The other two included one early abortion at gestational Week 12 during ongoing ECU therapy and one late foetal death at gestational Week 33 + 3, most likely not related to complement dysregulation. Kidney transplant function after delivery remained stable in all but one pregnancy. In the aforementioned case, a severe cTMA flare occurred after delivery despite use of preventive plasma infusions. Kidney graft function could be rescued in this patient by ECU. As such, successful pregnancies can be accomplished in kidney transplant recipients (KTRs) with a history of cTMA. We used preemptive plasma therapy or ongoing ECU treatment in selected cases.

Conclusions
Thus, becoming pregnant can be encouraged in KTRs with native kidney cTMA. Extensive preconception counselling, however, is mandatory in such cases.
ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma
Authors: Opitz Isabelle , Scherpereel Arnaud , Berghmans Thierry , Psallidas Ioannis , Glatzer Markus , Rigau David , Astoul Philippe , Bölükbas Servet , Boyd Jeanette , Coolen Johan , De Bondt Charlotte , De Ruysscher Dirk , Durieux Valerie , Faivre-Finn Corinne , Fennell Dean A , Galateau-Salle Francoise , Greillier Laurent , Hoda Mir Ali , Klepetko Walter , Lacourt Aude , McElnay Phil , Maskell Nick A , Mutti Luciano , Pairon Jean-Claude , Van Schil Paul , van Meerbeeck Jan P , Waller David , Weder Walter , Putora Paul Martin , Cardillo Giuseppe 
Published: May 2020

AbstractThe European Respiratory Society (ERS)/European Society of Thoracic Surgeons (ESTS)/European Association for Cardio-Thoracic Surgery (EACTS)/European Society for Radiotherapy and Oncology (ESTRO) task force brought together experts to update previous 2009 ERS/ESTS guidelines on management of malignant pleural mesothelioma (MPM), a rare cancer with globally poor outcome, after a systematic review of the 2009–2018 literature. The evidence was appraised using the Grading of Recommendations, Assessment, Development and Evaluation approach. The evidence syntheses were discussed and recommendations formulated by this multidisciplinary group of experts. Diagnosis: pleural biopsies remain the gold standard to confirm the diagnosis, usually obtained by thoracoscopy but occasionally via image-guided percutaneous needle biopsy in cases of pleural symphysis or poor performance status. Pathology: standard staining procedures are insufficient in ∼10% of cases, justifying the use of specific markers, including BAP-1 and CDKN2A (p16) for the separation of atypical mesothelial proliferation from MPM. Staging: in the absence of a uniform, robust and validated staging system, we advise using the most recent 2016 8th TNM (tumour, node, metastasis) classification, with an algorithm for pretherapeutic assessment. Monitoring: patient’s performance status, histological subtype and tumour volume are the main prognostic factors of clinical importance in routine MPM management. Other potential parameters should be recorded at baseline and reported in clinical trials. Treatment: (chemo)therapy has limited efficacy in MPM patients and only selected patients are candidates for radical surgery. New promising targeted therapies, immunotherapies and strategies have been reviewed. Because of limited data on the best combination treatment, we emphasize that patients who are considered candidates for a multimodal approach, including radical surgery, should be treated as part of clinical trials in MPM-dedicated centres.
Do oral amino acid supplements facilitate the healing of rat lung injuries?
Authors: Ersöz Hasan , Ağababaoğlu İsmail , Taylan İbrahim , Çakır Ebru , Aksun Saliha , Güneli Ensari 
Published: May 2020

Abstract

OBJECTIVES

Prolonged air leaks following lung injury cause extended hospital stays. This study investigated the effect of nutritional supplements containing arginine, glutamine and β-hydroxy β-methyl butyrate, which were theoretically proven to accelerate wound healing, on air leak and wound healing parameters in a rat lung injury model.

METHODS
Twenty-eight female rats were randomly divided into 4 groups. Experimental groups were given glutamine (Resource Glutamine®) or a mixture of arginine, glutamine and β-hydroxy β-methyl butyrate (Abound®) as a dietary supplement at isonitrogenous and isocaloric doses. On day 3, standard sized lung injuries were created in all rats except the sham group. The rats were sacrificed on day 6, and the lungs were removed for air-leak threshold pressure measurement and histopathological and biochemical analyses.

RESULTS
Loss of body mass was greater in the glutamine group than in the other groups (P = 0.004). Rats that received the amino acid mixture had better results for mature collagen fibre density (P = 0.002) and inflammation suppression (P = 0.003). The sham group had higher values for air-leak threshold pressure and all other histochemical parameters compared to the other groups. Hydroxyproline level did not differ significantly in any of the groups.

CONCLUSIONS
Our results indicated that an oral amino acid mixture was effective in the healing of lung injuries. Isolated glutamine supplementation had an adverse impact on body mass. Randomized clinical studies including larger series are needed. Hydroxyproline does not seem to be a suitable marker for this purpose.
Learning about fiscal multipliers during the European sovereign debt crisis: evidence from a quasi-natural experiment
Authors: Górnicka Lucyna , Kamps Christophe , Koester Gerrit , Leiner-Killinger Nadine 
Published: May 2020

SUMMARY
Identifying fiscal multipliers, that is, the effect of discretionary fiscal actions on growth, is challenging. It requires comparing the realization of growth after a fiscal action to a hypothetical growth path that would have prevailed in the absence of such action. Deriving the hypothetical path usually involves very strong assumptions. This paper helps to relax some of the assumptions, using a unique new data set on the European Commission’s recommendations under the so-called excessive deficit procedure (EDP). These recommendations provide information on both output growth in a no-policy-change baseline forecast and an alternative forecast of growth incorporating the size of fiscal consolidation recommended under the EDP. A comparison of these two alternative scenarios allows us to infer country-specific fiscal multipliers implicitly applied by the Commission in its EDP recommendations for a sample of 24 countries over the period 2009–2015. Our results confirm Blanchard and Leigh’s (2013, 2014) presumption that fiscal multipliers used by forecasters were adjusted upwards during the European sovereign debt crisis, albeit starting from lower than commonly assumed levels. Contrary to Blanchard and Leigh (2013, 2014), we do not find evidence that the ‘true’ ex-post fiscal multipliers systematically exceeded 1 in the early crisis years.
Clinical Correlates and Outcome of Major Depressive Disorder and Comorbid Migraine: A Report of the European Group for the Study of Resistant Depression
Authors: Fugger Gernot , Dold Markus , Bartova Lucie , Mitschek Marleen M M , Souery Daniel , Mendlewicz Julien , Serretti Alessandro , Zohar Joseph , Montgomery Stuart , Fabbri Chiara , Frey Richard , Kasper Siegfried 
Published: May 2020

Abstract

Background
The present multicenter study aimed at defining the clinical profile of patients with major depressive disorder (MDD) and comorbid migraine.

Methods
Demographic and clinical information for 1410 MDD patients with vs without concurrent migraine were compared by descriptive statistics, analyses of covariance, and binary logistic regression analyses.

Results
The point prevalence rate for comorbid migraine was 13.5% for female and 6.2% for male patients. MDD + migraine patients were significantly younger, heavier, more likely female, of non-Caucasian origin, outpatient, and suffering from asthma. The presence of MDD + migraine resulted in a significantly higher functional disability. First-line antidepressant treatment strategy revealed a trend towards agomelatine. Second-generation antipsychotics were significantly less often administered for augmentation treatment in migraineurs. Overall, MDD + migraine patients tended to respond worse to their pharmacotherapy.

Conclusion
Treatment guidelines for comorbid depression and migraine are warranted to ensure optimal efficacy and avoid possible pitfalls in psychopharmacotherapy, including serotonin syndrome.
A Sharp Multidimensional Hermite–Hadamard Inequality
Authors: Larson Simon 
Published: May 2020

Abstract
Let $\Omega \subset {\mathbb{R}}^d $, $d \geq 2$, be a bounded convex domain and $f\colon \Omega \to{\mathbb{R}}$ be a non-negative subharmonic function. In this paper, we prove the inequality $$\begin{equation*} \frac{1}{|\Omega|}\int_{\Omega} f(x)\, \textrm{d}x \leq \frac{d}{|\partial\Omega|}\int_{\partial\Omega} f(x)\, \textrm{d}\sigma(x)\,. \end{equation*}$$Equivalently, the result can be stated as a bound for the gradient of the Saint Venant torsion function. Specifically, if $\Omega \subset{\mathbb{R}}^d$ is a bounded convex domain and $u$ is the solution of $-\Delta u =1$ with homogeneous Dirichlet boundary conditions, then $$\begin{equation*} \|\nabla u\|_{L^\infty(\Omega)} &lt; d\frac{|\Omega|}{|\partial\Omega|}\,. \end{equation*}$$Moreover, both inequalities are sharp in the sense that if the constant $d$ is replaced by something smaller there exist convex domains for which the inequalities fail. This improves upon the recent result that the optimal constant is bounded from above by $d^{3/2}$ due to Beck et al. [2].
Toward a Volitional Definition of Religion
Authors: Nemec John 
Published: May 2020

AbstractThis article advocates for the production of stipulative definitions of religion, a type of nominal definition that articulates new ways of applying a word to a thing. I propose that scholars look to sites where phenomena historically have been labeled “religion” on lexical or real understandings of the term, this to query how religious agents there chose, implicitly or explicitly, to systematize thought, speech, emotion, and action. Such self-consciously ordered systems, I argue, may properly be labeled “religion.” Next, I apply this method to premodern South Asia, suggesting “religion” refers to the second-order structuring there that links normative social relations to normative states of subjectivity, any innovation in the one demanding innovation in the other. I conclude by inviting other efforts at stipulative definition, all with an eye toward an inductive approach, allowing that the myriad locations of religion present mutually distinguishable systems that may all properly be so labeled.
Xanthogranulomatous cholecystitis complicated by a cholecysto-colonic fistula and liver abscesses†
Authors: Morare Nolitha , Mpuku Lwazi , Ally Zain 
Published: May 2020

Abstract
A 57-year-old male presented to the emergency department with right upper quadrant pain and constitutional symptoms. Initial investigation revealed biliary sepsis with features of chronic cholecystitis, multiple liver abscesses and a fistulous connection between the gallbladder and colon. He was subsequently diagnosed with a cholecysto-colonic fistula, an unusual complication of biliary pathology, with an incidence of 0.06–0.14% at cholecystectomy. It is the second most common form of cholecystoenteric fistula, the first of which is cholecystoduodenal. A preoperative diagnosis was suggested using computed tomography and sinogram imaging. The associated liver abscesses together with the xanthogranulomatous inflammation found on histopathology, makes the case particularly exceptional.
Malaria in the Pregnant Traveler
Authors: McKinney Kimberly L , Wu Henry M , Tan Kathrine R , Gutman Julie R 
Published: May 2020

Abstract
Pregnant travelers face numerous risks, notably increased susceptibility to or severity of multiple infections, including malaria. Because pregnant women residing in areas non-endemic for malaria are unlikely to have protective immunity, travel to endemic areas poses risk of severe illness and pregnancy complications, such as low birthweight and fetal loss. If travel to malaria endemic areas cannot be avoided, preventive measures are critical. However, malaria chemoprophylaxis in pregnancy can be challenging, since commonly used regimens have varying levels of safety data, and national guidelines differ. Furthermore, although chloroquine and mefloquine have wide acceptance for use in pregnancy, regional malaria resistance and non-pregnancy contraindications limit their use. Mosquito repellents, including DEET and permethrin treatment of clothing, are considered safe in pregnancy and important to prevent malaria as well as other arthropod-borne infections such as Zika virus infection. Pregnant travelers at risk for malaria exposure should be advised to seek medical attention immediately if any symptoms of illness, particularly fever, develop.
NATpare: a pipeline for high-throughput prediction and functional analysis of nat-siRNAs
Authors: Thody Joshua , Folkes Leighton , Moulton Vincent 
Published: May 2020

Abstract
Natural antisense transcript-derived small interfering RNAs (nat-siRNAs) are a class of functional small RNA (sRNA) that have been found in both plant and animals kingdoms. In plants, these sRNAs have been shown to suppress the translation of messenger RNAs (mRNAs) by directing the RNA-induced silencing complex (RISC) to their sequence-specific mRNA target(s). Current computational tools for classification of nat-siRNAs are limited in number and can be computationally infeasible to use. In addition, current methods do not provide any indication of the function of the predicted nat-siRNAs. Here, we present a new software pipeline, called NATpare, for prediction and functional analysis of nat-siRNAs using sRNA and degradome sequencing data. Based on our benchmarking in multiple plant species, NATpare substantially reduces the time required to perform prediction with minimal resource requirements allowing for comprehensive analysis of nat-siRNAs in larger and more complex organisms for the first time. We then exemplify the use of NATpare by identifying tissue and stress specific nat-siRNAs in multiple Arabidopsis thaliana datasets.
Specific Features of Criminal Proceeding Regarding Criminal Misdemeanours
Authors: Vapniarchuk Viacheslav V , Bespalko Inna L , Motoryhina Maryna G 
Published: May 2020

Abstract
The urgency of the problem stated in the article is conditioned by amendments to the criminal procedural legislation, which in a new way regulate the procedure of criminal proceedings concerning criminal offences. The aim of the article is to investigate the procedure for conducting criminal proceedings for criminal offences and to make suggestions for improving its regulatory framework. The basic approach to the study of this problem was to conduct a critical analysis of the rules of the current criminal procedural legislation, which regulate criminal proceedings for criminal offences, and to express views on rules’ proper understanding and application. Based on the analysis of the features of the normative regulation of criminal proceedings concerning criminal offences, the publication comments on a number of norms of the current Criminal Procedure Code of Ukraine, which regulate both pre-trial investigation of criminal offences in the form of enquiries and court proceedings against them; approaches to their elimination have been proposed. The materials of the article represent both theoretical and practical values. They can be used for further scientific investigation of the features of criminal proceedings regarding criminal offences, as well as for the proper understanding and implementation of law enforcement criminal proceedings.
Overexpression of Populus transcription factor PtrTALE12 increases axillary shoot development by regulating WUSCHEL expression
Authors: Bae So-Young , Kim Min-Ha , Cho Jin-Seong , Park Eung-Jun , Lee Hyoshin , Kim Jeong-Hoe , Ko Jae-Heung 
Published: May 2020

Abstract
The TALE (Three Amino acid Loop Extension) transcription factor family has been shown to control meristem formation and organogenesis in plants. To understand the functional roles of the TALE family in woody perennials, each of the TALE members of Populus trichocarpa was overexpressed in Arabidopsis as a proxy. Among them, the overexpression of PtrTALE12 (i.e., 35S::PtrTALE12) resulted in a dramatic increase of axillary shoot development with early flowering. Interestingly, expression of WUSCHEL (WUS), a central regulator of both apical and axillary meristem formation, was significantly increased in the 35S::PtrTALE12 Arabidopsis plants. Conversely, WUS expression was downregulated in 35S::PtrTALE12-SRDX (short transcriptional repressor domain) plants. Further analysis found that PtrTALE12, expressed preferentially in meristem tissues, directly regulates WUS expression in transient activation assays using Arabidopsis leaf protoplast. Yeast two-hybrid assays showed that PtrTALE12 interacts with SHOOT MERISTEMLESS (STM); however, the interaction does not affect the WUS expression. In addition, expression of both CIRCADIAN CLOCK ASSOCIATED1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY) genes was suppressed accordingly for early flowering 35S::PtrTALE12 Arabidopsis. Indeed, transgenic poplars overexpressing PtrTALE12 as well as Arabidopsis plants overexpressing AtBLH11, a close homolog of PtrTALE12, phenocopied the 35S::PtrTALE12 Arabidopsis (i.e., increased axillary shoot development). Taken together, our results suggest that PtrTALE12 functions as a positive regulator of axillary shoot formation in both Arabidopsis and poplar.