bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of outcomes between patients with de‐novo sinonasal squamous cell carcinoma vs malignant transformations from inverted papillomas
Authors: Quan Huatao , Zhang Haiyan , Zou Lifen , Yuan Wei , Wang Shengzi 
Published: March 2020

BackgroundThe survival difference between de‐novo sinonasal squamous cell carcinoma (DN‐SNSCC) and SCC arising from inverted papillomas (IPs) is unclear. The purpose of this study was to compare the outcomes between DN‐SNSCC and IP‐transformed SNSCC (IP‐SNSCC) patients.MethodsIn this retrospective review, we compared IP‐SNSCC and DN‐SNSCC cases from the Eye and ENT Hospital of Fudan University from 2010 to 2017. A total of 162 patients (39 IP‐SNSCC and 123 DN‐SNSCC) were included in our study. Demographics, tumor characteristics, treatment, and clinical outcomes were analyzed.ResultsThe median follow‐up time in all cohorts was 56 (range, 5‐109) months. There was no difference in age, sex, smoking history, alcohol consumption, tumor primary site, or disease stage between the IP‐SNSCC and DN‐SNSCC patients. We also did not find significant differences in overall survival and disease‐free survival between IP‐SNSCC and DN‐SNSCC patients (p = 0.584 and p = 0.238, respectively). The 5‐year local failure rate was 52.8% for IP‐SNSCC patients, which was significantly higher than for those with DN‐SNSCC (31.9%; p = 0.013). The 5‐year nodal failure rate was 19.0% for IP‐SNSCC patients and 8.5% for DN‐SNSCC patients (p = 0.211). The 5‐year distant metastasis rate was 8.0% for IP‐SNSCC patients and 16.1% for DN‐SNSCC patients (p = 0.318).ConclusionIP‐SNSCC and DN‐SNSCC patients have similar survival outcomes. IP‐SNSCC seems to have exhibited a higher local failure rate in our study. We believe that IP‐SNSCC is a highly aggressive disease that requires radical treatment. Prophylactic neck treatment should not be omitted in a subset of IP‐SNSCC patients.
Antiepileptic Drug Teratogenicity and De Novo Genetic Variation Load
Authors: Perucca Piero , Anderson Alison , Jazayeri Dana , Hitchcock Alison , Graham Janet , Todaro Marian , Tomson Torbjörn , Battino Dina , Perucca Emilio , Ferri Meritxell Martinez , Rochtus Anne , Lagae Lieven , Canevini Maria Paola , Zambrelli Elena , Campbell Ellen , Koeleman Bobby P. C. , Scheffer Ingrid E. , Berkovic Samuel F. , Kwan Patrick , Sisodiya Sanjay M. , Goldstein David B. , Petrovski Slavé , Craig John , Vajda Frank J. E. , O'Brien Terence J. ,   the EpiPGX and EPIGEN Consortia
Published: March 2020

ObjectiveThe mechanisms by which antiepileptic drugs (AEDs) cause birth defects (BDs) are unknown. Data suggest that AED‐induced BDs may result from a genome‐wide increase of de novo variants in the embryo, a mechanism that we investigated.MethodsWhole exome sequencing data from child–parent trios were interrogated for de novo single‐nucleotide variants/indels (dnSNVs/indels) and de novo copy number variants (dnCNVs). Generalized linear models were applied to assess de novo variant burdens in children exposed prenatally to AEDs (AED‐exposed children) versus children without BDs not exposed prenatally to AEDs (AED‐unexposed unaffected children), and AED‐exposed children with BDs versus those without BDs, adjusting for confounders. Fisher exact test was used to compare categorical data.ResultsSixty‐seven child–parent trios were included: 10 with AED‐exposed children with BDs, 46 with AED‐exposed unaffected children, and 11 with AED‐unexposed unaffected children. The dnSNV/indel burden did not differ between AED‐exposed children and AED‐unexposed unaffected children (median dnSNV/indel number/child [range] = 3 [0–7] vs 3 [1–5], p = 0.50). Among AED‐exposed children, there were no significant differences between those with BDs and those unaffected. Likely deleterious dnSNVs/indels were detected in 9 of 67 (13%) children, none of whom had BDs. The proportion of cases harboring likely deleterious dnSNVs/indels did not differ significantly between AED‐unexposed and AED‐exposed children. The dnCNV burden was not associated with AED exposure or birth outcome.InterpretationOur study indicates that prenatal AED exposure does not increase the burden of de novo variants, and that this mechanism is not a major contributor to AED‐induced BDs. These results can be incorporated in routine patient counseling. ANN NEUROL 2020;87:897–906
Titanocenes as Photoredox Catalysts Using Green‐Light Irradiation
Authors: Zhang Zhenhua , Hilche Tobias , Slak Daniel , Rietdijk Niels R. , Oloyede Ugochinyere N. , Flowers Robert A. , Gansäuer Andreas 
Published: March 2020

AbstractIrradiation of Cp2TiCl2with green light leads to electronically excited [Cp2TiCl2]*. This complex constitutes an efficient photoredox catalyst for the reduction of epoxides and for 5‐exocyclizations of suitably unsaturated epoxides. To the best of our knowledge, our system is the first example of a molecular titanium photoredox catalyst.
Preparation and characterization of cellulose‐based nanocomposite hydrogel films containing CuO/Cu2O/Cu with antibacterial activity
Authors: Dharmalingam Koodalingam , Bordoloi Devivasha , Kunnumakkara Ajaikumar B. , Anandalakshmi Ramalingam 
Published: March 2020

AbstractIn the present study, the influence of citric acid (CA) on hydrogel films composed of sodium carboxymethylcellulose (NaCMC), hydroxypropylmethylcellulose (HPMC), and CuO nanoflakes was investigated for their physicochemical, mechanical, thermal, and antibacterial properties. XRD patterns showed that the prepared hydrogel films revealed the crystalline phase for CuO/Cu2O/Cu at 20% CA concentration. Laser micro‐Raman spectroscopy confirmed the presence of CuO and Cu2O in the films. Increase in CA concentration decreased the swelling degree and tensile strength and increased the decomposition temperature of NaCMC, HPMC, and CuO. According to FESEM and FETEM results, shape and size of CuO nanoflakes were completely changed into spherical nanoparticles with increase in CA concentration. HRTEM and inverse Fourier transform images showed that the d‐spacing of CuO, Cu2O, and Cu were correlated with XRD results. The prepared hydrogel films exhibited significant antibacterial activity and biocompatibility against HaCaT cells. All these data recommend that the prepared hydrogel films may be used for potential wound healing applications.
The Utility of Plasma Vascular Biomarkers in Systemic Sclerosis: A Prospective Longitudinal Analysis
Authors: Mecoli Christopher A. , Shah Ami A. , Boin Francesco , Wigley Fredrick M. , Hummers Laura K. 
Published: March 2020

ObjectiveIn cross‐sectional studies, pulmonary hypertension (PH) and ischemic digital lesions are 2 scleroderma vascular outcomes associated with abnormalities in biomarkers of angiogenesis. The clinical usefulness of these biomarkers is unknown, in part due to lack of data on longitudinal measurement. This prospective longitudinal study was undertaken to evaluate vascular biomarker measurements in patients with systemic sclerosis (SSc) over time.MethodsWe conducted a prospective cohort study of 300 patients with SSc who were followed up for at least a 5‐year period and lacked evidence of PH and/or active ischemic digital lesions at enrollment. Levels of hepatocyte growth factor (HGF), soluble Flt‐1 (sFlt‐1), soluble endoglin, endostatin, and placental growth factor (PLGF) were obtained at multiple time points and assessed for their ability to predict the development of PH/ischemic digital lesions. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated.ResultsForty‐six patients (15%) developed PH and 69 patients (23%) developed an ischemic digital lesion. In time‐to‐event analyses, the following 3 biomarkers measured at cohort entry were found to be significantly associated with the development of PH: HGF (HR 1.99 [95% CI 1.24–3.17], P = 0.004), sFlt‐1 (HR 3.04 [95% CI 1.29–7.14], P = 0.011), and PLGF (HR 2.74 [95% CI 1.32–5.69], P = 0.007). As time approaching PH diagnosis decreased, there was no corresponding increase in any biomarker level. Upon converting each continuous vascular biomarker into a binary variable, a dose‐response relationship was observed for the number of elevated biomarkers at cohort entry and the risk of developing PH. With each additional elevated biomarker at cohort entry, there was a 78% increase in the risk of developing PH (HR 1.78 [95% CI 1.2–2.6], P = 0.004).ConclusionThese data suggest that molecules involved in angiogenesis reflect vascular perturbation, and that elevations in these biomarkers at first encounter can indicate patients who are at risk of PH development.
Planar 2‐Pyridyl‐1,2,3‐triazole Derived Metallo‐ligands: Self‐assembly with PdCl2 and Photocatalysis
Authors: Lagesse Natalie R. , Tan Kelvin Y. L. , Crowley James D. , Findlay James A. 
Published: March 2020

AbstractSelf‐assembled metallosupramolecular architectures (MSAs) with built‐in functionalities such as light‐harvesting metal centers are a promising approach for developing emergent properties within discrete molecular systems. Herein we describe the synthesis of two new but simple “click” ligands featuring a bidentate 2‐pyridyl‐1,2,3‐triazole chelate pocket linked to a monodentate pyridyl (either 3‐ or 4‐substituted, L1 and L2) unit. The ligands and the corresponding four PdIIand PtIImetallo‐ligands (Pd1, Pd2, Pt1 and Pt2) were synthesized and characterized using nuclear magnetic resonance (NMR) spectroscopy, electrospray ionization mass spectrometry (ESI‐MS), and X‐ray crystallography. Solid‐state characterization of the series of ligands and metallo‐ligands revealed that these compounds display a co‐planar conformation of all the aryl units. The PtIIcontaining metallo‐ligands (Pt1 and Pt2) were found to assemble into square (Sqr) and triangular (Tri) shaped architectures when combined with neutral PdCl2 linker units. Additionally, the ability of the PtIImetallo‐ligands and Tri to photocatalyze the cycloaddition of singlet oxygen to anthracene was investigated.
Adaptive geometric control of quadrotors with dynamic offset between center of gravity and geometric center
Authors: Sharma Manmohan , Kar Indrani 
Published: March 2020

AbstractA geometric adaptive control of quadrotors has been proposed in this paper when the center of gravity of the quadrotor is different from its geometric center. The unique feature of the controller is the use of left tracking error function to simplify controller design. The inertia matrix, mass as well as the center of gravity are assumed to be unknown and coordinate invariant adaptive laws have been derived for the estimate of these mentioned parameters. The coordinate invariant approach is another unique feature of the proposed method as opposed to the literature. Rigorous mathematical proofs have been prescribed to show the stability of the complete closed loop dynamics under the proposed adaptive laws. The controller has been derived under the assumption that the rotational dynamics is faster than the translational dynamics. Numerical simulations have been shown at the end to show the effectiveness of the proposed method.
Transient performance improvement of Takagi‐Sugeno fuzzy systems by modified non‐parallel distributed compensation controller
Authors: Vafamand Navid 
Published: March 2020

AbstractThis paper addresses the transient performance of nonlinear systems described by Takagi‐Sugeno (TS) fuzzy models. To achieve this goal, a modified fuzzy controller and a non‐quadratic Lyapunov function (NQLF) are utilized. The fuzzy controller comprises an α‐delayed non‐parallel distributed compensation (non‐PDC) and a nonlinear modifying term. The α‐delayed non‐PDC assures the global stabilization of the TS fuzzy systems through the NQLF and linear matrix inequality (LMI) numerical technique. Moreover, the modifying term is used to enhance the transient performance. It is shown that the stability of the closed‐loop system is guaranteed by the α‐delayed non‐PDC and the performance is improved by the modifying term. Two different selections for the modifying term are presented and that they can increase the reaching time of the response and lead to the finite‐time convergence of the state to their equilibrium point is proven. Several numerical and practical systems, that is, a single‐link manipulator and a chaotic permanent magnet synchronous machine, are simulated to illustrate the advantages of the proposed approach. The obtained numerical results are compared with other state‐of‐the‐art methods.
Optimal Control for Discrete‐time Descriptor Noncausal Systems
Authors: Shu Yadong 
Published: March 2020

AbstractIn this paper, optimal control problems governed by linear discrete‐time descriptor noncausal systems (with quadratic input variables) are investigated in order. A descriptor system assumed to be regular alone is called descriptor noncausal system. According to Bellman's principle of optimality in dynamic programming, a recurrence equation for simplifying the optimal control problems is derived. Then, employing the recurrence equation, a bang‐bang optimal control problem subject to a linear descriptor noncausal system and an optimal control problem subject to a descriptor noncausal system with quadratic input variables are both settled, and the optimal solutions are given through exact expressions. A numerical example is presented to illustrate the effectiveness of the results obtained concerning the bang‐bang optimal control problem.
Electrolytes for Lithium (Sodium) Batteries Based on Ionic Liquids: Highlighting the Key Role Played by the Anion
Authors: Rüther Thomas , Bhatt Anand I. , Best Adam S. , Harris Kenneth R. , Hollenkamp Anthony F. 
Published: March 2020

AbstractResearch since 2000 has clearly shown that ionic liquids (ILs) and their metal salt containing mixtures have good potential to be considered as electrolytes (ILELs) in lithium and other electropositive metal (ion) batteries. This outcome is particularly relevant for the operation of such devices in elevated temperature regimes where ILELs would have a significant advantage over the conventional organic carbonate solvent/LiPF6 electrolytes that, due to their limited thermal stability and flammability, cause concerns about the safety of current LIB technology. There is evidence from a number of review articles that physicochemical properties can be tailored such that ILELs could meet requirements for operating in batteries at lower temperature regimes. By drawing on a broad range of cation/anion combinations, there is further evidence from these papers that within a particular family of cations, the physicochemical properties of ILs and ILELs are largely defined by the anion component. Despite the key role of the anion there are few reviews that have sections dedicated to this aspect. This review surveys the physicochemical, transport and structural properties of ILs (mainly pyrrolidinium salts) and ILELs employing prominent and representative anion classes.
ASXL1 mutation as a surrogate marker in acute myeloid leukemia with myelodysplasia‐related changes and normal karyotype
Authors: Prats‐Martín Concepción , Burillo‐Sanz Sergio , Morales‐Camacho Rosario M. , Pérez‐López Olga , Suito Milagros , Vargas Maria T. , Caballero‐Velázquez Teresa , Carrillo‐Cruz Estrella , González José , Bernal Ricardo , Pérez‐Simón José A. 
Published: March 2020

AbstractAcute myeloid leukemia with myelodysplasia‐related changes (AML‐MRC) are poor outcome leukemias. Its diagnosis is based on clinical, cytogenetic, and cytomorphologic criteria, last criterion being sometimes difficult to assess. A high frequency of ASXL1 mutations have been described in this leukemia. We sequenced ASXL1 gene mutations in 61 patients with AML‐MRC and 46 controls with acute myeloid leukemia without other specifications (AML‐NOS) to identify clinical, cytomorphologic, and cytogenetic characteristics associated with ASXL1 mutational status. Mutated ASXL1 (ASXL1+) was observed in 31% of patients with AML‐MRC compared to 4.3% in AML‐NOS. Its presence in AML‐MRC was associated with older age, a previous history of myelodysplastic syndrome (MDS) or myelodysplastic/myeloproliferative neoplasms (MDS/MPN), leukocytosis, presence of micromegakaryocytes in bone marrow, lower number of blasts in bone marrow, myelomonocytic/monocytic morphological features and normal karyotype. ASXL1 mutation was not observed in patients with myelodysplastic syndrome‐related cytogenetic abnormalities or TP53 mutations. Differences in terms of overall survival were found only in AML‐MRC patients without prior MDS or MDS/MPN and with intermediate‐risk karyotype, having ASXL1+ patients a worst outcome than ASXL1−. We conclude that the ASXL1 mutation frequency is high in AML‐MRC patients being its presence associated with specific characteristics including morphological signs of dysplasia. This association raises the possible role of ASXL1 as a surrogate marker in AML‐MRC, which could facilitate the diagnosis of patients within this group when the karyotype is normal, and especially when the assessment of multilineage dysplasia morphologically is difficult. This mutation could be used as a worst outcome marker in de novo AML‐MRC with intermediate‐risk karyotype.
Biosynthetic Plasticity Enables Production of Fluorinated Aurachins
Authors: Sester Angela , Stüer‐Patowsky Katrin , Hiller Wolf , Kloss Florian , Lütz Stephan , Nett Markus 
Published: March 2020

AbstractEnzyme promiscuity has important implications in the field of biocatalysis. In some cases, structural analogues of simple metabolic building blocks can be processed through entire pathways to give natural product derivatives that are not readily accessible by chemical means. In this study, we explored the plasticity of the aurachin biosynthesis pathway with regard to using fluoro‐ and chloroanthranilic acids, which are not abundant in the bacterial producers of these quinolone antibiotics. The incorporation rates of the tested precursor molecules disclosed a regiopreference for halogen substitution as well as steric limitations of enzymatic substrate tolerance. Three previously undescribed fluorinated aurachin derivatives were produced in preparative amounts by fermentation and structurally characterized. Furthermore, their antibacterial activities were evaluated in comparison to their natural congener aurachin D.
Procedural, pregnancy, and short‐term outcomes after fetal aortic valvuloplasty
Authors: Patel Neil D. , Nageotte Stephen , Ing Frank F. , Armstrong Aimee K. , Chmait Ramen , Detterich Jon A. , Galindo Alberto , Gardiner Helena , Grinenco Sofia , Herberg Ulrike , Jaeggi Edgar , Morris Shaine A. , Oepkes Dick , Simpson John M. , Moon‐Grady Anita , Pruetz Jay D. 
Published: March 2020

AbstractObjectivesWe aimed to evaluate the effect of technical aspects of fetal aortic valvuloplasty (FAV) on procedural risks and pregnancy outcomes.BackgroundFAV is performed in cases of severe mid‐gestation aortic stenosis with the goal of preventing hypoplastic left heart syndrome (HLHS).MethodsThe International Fetal Cardiac Intervention Registry was queried for fetuses who underwent FAV from 2002 to 2018, excluding one high‐volume center.ResultsThe 108 fetuses had an attempted cardiac puncture (mean gestational age [GA] 26.1 ± 3.3 weeks). 83.3% of attempted interventions were technically successful (increased forward flow/new aortic insufficiency). The interventional cannula was larger than 19 g in 70.4%. More than one cardiac puncture was performed in 25.0%. Intraprocedural complications occurred in 48.1%, including bradycardia (34.1%), pericardial (22.2%) or pleural effusion (2.7%) requiring drainage, and balloon rupture (5.6%). Death within 48 hr occurred in 16.7% of fetuses. Of the 81 patients born alive, 59 were discharged home, 34 of whom had biventricular circulation. More than one cardiac puncture was associated with higher complication rates (p < .001). Larger cannula size was associated with higher pericardial effusion rates (p = .044). On multivariate analysis, technical success (odds ratio [OR] = 10.9, 95% confidence interval [CI] = 2.2–53.5, p = .003) and later GA at intervention (OR = 1.5, 95% CI = 1.2–1.9, p = .002) were associated with increased odds of live birth.ConclusionsFAV is an often successful but high‐risk procedure. Multiple cardiac punctures are associated with increased complication and fetal mortality rates. Later GA at intervention and technical success were independently associated with increased odds of live birth. However, performing the procedure later in gestation may miss the window to prevent progression to HLHS.
Efficient Transfer Hydrogenation of Ketones using Methanol as Liquid Organic Hydrogen Carrier
Authors: Garg Nidhi , Paira Soumen , Sundararaju Basker 
Published: March 2020

AbstractHerein, we demonstrate an efficient protocol for transfer hydrogenation of ketones using methanol as practical and useful liquid organic hydrogen carrier (LOHC) under Ir(III) catalysis. Various ketones, including electron‐rich/electron‐poor aromatic ketones, heteroaromatic and aliphatic ketones, have been efficiently reduced into their corresponding alcohols. Chemoselective reduction of ketones was established in the presence of various other reducible functional groups under mild conditions.
Partially Graphitized Iron−Carbon Hybrid Composite as an Electrochemical Supercapacitor Material
Authors: Manippady Sai Rashmi , Singh Ashish , Rout Chandra Sekhar , Samal Akshaya Kumar , Saxena Manav 
Published: March 2020

AbstractThe conversion of biomass into valuable carbon composites as an efficient non‐precious energy storage electrode material has elicited extensive research interest. An as‐synthesized partially graphitized iron oxide‐carbon composite material (Fe3O4/Fe3C@C) shows excellent properties as an electrode material for supercapacitor applications. X‐ray diffraction analysis, high‐resolution transmission electron microscopy, X‐ray photoelectron spectroscopy and Brunauer‐Emmett‐Teller analysis are used to study the structural, compositional and surface areal properties. The electrode material shows a specific surface area of 827.4 m2/g. Owing to the synergistic effect of the graphitic layers with iron oxide/carbide, Fe3O4/Fe3C@C hybrid electrode materials display a high performance when used in supercapacitors, with an excellent capacity of 878 F/g at a current density of 5 A/g (3‐electrode) and 211.6 F/g at a current density of 0.4 A/g (2‐electrode) in 6 M KOH electrolyte with good cyclic stability.
Poly(methyl methacrylate)‐Assisted Exfoliation of Graphite and Its Use in Acrylonitrile‐Butadiene‐Styrene Composites
Authors: Gentiluomo Silvia , Thorat Sanjay B. , Del Río Castillo Antonio Esau , Toth Peter S. , Panda Jaya Kumar , Pellegrini Vittorio , Bonaccorso Francesco 
Published: March 2020

AbstractOne of the applications of graphene in which its scalable production is of utmost importance is the development of polymer composites. Among the techniques used to produce graphene flakes, the liquid‐phase exfoliation (LPE) of graphite stands out due to its versatility and scalability. However, solvents suitable for the LPE process are generally toxic and have a high boiling point, making the processing challenging. The use of low boiling point solvents could be convenient for the processing, due to the easiness of their removal. In this study, the use of poly(methyl methacrylate) (PMMA) as a stabilizing agent is proposed for the production of graphene flakes in a low boiling point solvent, that is, acetone. The graphene dispersions produced in the mixture acetone‐PMMA have higher concentration, +175 %, and contain a higher percentage of few‐layer graphene flakes (<5 layers), that is, +60 %, compared to the dispersions prepared in acetone. The as‐produced graphene dispersions are used to develop graphene/acrylonitrile‐butadiene‐styrene composites. The mechanical properties of the pristine polymer are improved, that is, +22 % in the Young's modulus, by adding 0.01 wt. % of graphene flakes. Moreover, a decrease of ≈20 % in the oxygen permeability is obtained by using 0.1 wt. % of graphene flakes filler, compared to the unloaded matrix.