bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neonatal systemic gene therapy restores cardiorespiratory function in a rat model of Pompe disease
Authors: Fuller David D. , Rana Sabhya , Thakre Prajwal , Benevides Ethan , Pope Megan , Todd Adrian G. , Jensen Victoria N. , Vaught Lauren , Cloutier Denise , Ribas Roberto A. , Larson Reece C. , Gentry Matthew S. , Sun Ramon C. , Chandran Vijay , Corti Manuela , Falk Darin J. , Byrne Barry J. 
Published: December 2024

ABSTRACTAbsence of functional acid-α-glucosidase (GAA) leads to early-onset Pompe disease with cardiorespiratory and neuromuscular failure. A novel Pompe rat model (Gaa-/-) was used to test the hypothesis that neonatal gene therapy with adeno-associated virus serotype 9 (AAV9) restores cardiorespiratory neuromuscular function across the lifespan. Temporal vein administration of AAV9-DES-GAA or sham (saline) injection was done on post-natal day 1; rats were studied at 6-12 months old. Whole-body plethysmography showed that reduced inspiratory tidal volumes inGaa-/-rats were corrected by AAV-GAA treatment. Matrix- assisted laser desorption/ionization mass spectrometry imaging (MALDI) revealed that AAV-GAA treatment normalized diaphragm muscle glycogen as well as glycans. Neurophysiological recordings of phrenic nerve output and immunohistochemical evaluation of the cervical spinal cord indicated a neurologic benefit of AAV-GAA treatment.In vivomagnetic resonance imaging demonstrated that impaired cardiac volumes inGaa-/-rats were corrected by AAV-GAA treatment. Biochemical assays showed that AAV treatment increased GAA activity in the heart, diaphragm, quadriceps and spinal cord. We conclude that neonatal AAV9-DES-GAA therapy drives sustained, functional GAA expression and improved cardiorespiratory function in theGaa-/-rat model of Pompe disease.
Change in mental health trends in Scotland, UK pre- and post-COVID-19
Authors: Cooke Elizabeth A. , Lemanska Agnieszka , Thomas Spencer A. 
Published: December 2024

AbstractThe COVID-19 pandemic and national lockdowns have had profound impacts on population mental health in Scotland. In this study, we examine the impact on the relationship between the number of patients receiving in-patient care for mental health related diagnoses and the number of patients on waiting lists for mental health treatment. Prior to March 2020, increased waiting lists did not translate into an increase in hospital admissions. Post-March 2020, however, we found that more patients on waiting lists corresponded to more patients being hospitalised. Our analysis indicates that the relationship between waiting lists and in-patient treatment changed during the COVID-19 pandemic, and this may be contributing to additional pressures on hospitals and mental health services in Scotland.
Characteristics of effective interventions to optimise retention for early career nurses: a scoping review
Authors: White Krishangi , Goldsworthy Adrian , Bateup Sarah , Meigh Neil 
Published: December 2024

AbstractBackgroundNursing shortages, driven by high turnover rates among early career registered nurses (ECNs), present a critical global challenge, threatening workforce sustainability, compromising patient care quality, and imposing financial burdens on healthcare systems. While various interventions have been developed to improve retention, gaps in reporting, scalability, and long-term evaluation hinder their widespread adoption. This review applies Proctor et al.’s implementation science framework to evaluate the design and operationalisation of retention strategies, addressing existing gaps and identifying actionable insights.ObjectiveThis scoping review synthesises evidence on the characteristics of effective interventions designed to enhance retention and reduce turnover among ECNs.Inclusion criteriaThis review included studies evaluating interventions aimed at improving retention or reducing turnover of ECNs within the first five years of practice. Eligible studies presented original data or systematic reviews addressing intervention characteristics and outcomes.MethodsThe review adhered to the JBI methodology for scoping reviews and PRISMA-ScR guidelines. Systematic searches of Medline, EMBASE, PsycINFO, CINAHL, and the Cochrane Library were conducted in May 2024. Articles published in English were screened independently by two reviewers, with data extraction and synthesis guided by Proctor et al.’s implementation science framework. Results were synthesised narratively and presented in tabular formats.ResultsFrom 3,462 records, 21 studies met inclusion criteria. Interventions varied widely, including mentorship (n = 9), preceptorship (n = 8), in-person classes (n = 10), clinical simulations (n = 6), reflective practice, and career advancement programs. Program durations ranged from 8 weeks to 2 years, with one year being the most common. Factors associated with success included tailored content for ECNs, structured competency frameworks, mentor training, and integration into organisational leadership and culture. Challenges such as variable reporting standards and inconsistent evaluation methods were noted.ConclusionsEffective retention strategies for ECNs require structured, supportive, and competency-based interventions tailored to organisational and individual needs. Emphasising mentor preparation, career development, and specialised approaches for high-stress environments, such as critical care, can enhance program outcomes. Improved reporting standards and methodological rigour are necessary to scale and adapt these programs across healthcare systems, ultimately contributing to a more stable and resilient nursing workforce.
Partitioning and probe-based quantitative PCR assays for the wastewater monitoring ofMycobacterium tuberculosisComplex,M. tuberculosis, andM. Bovis
Authors: Nguyen Tram B. , Mercier Elisabeth , Wong Chandler H. , Hegazy Nada , Kabir Md Pervez , Tomalty Emma , Addo Felix , Ward Leonor , Renouf Elizabeth , Wan Shen , Tcholakov Yassen , Guilherme Stéphanie , Delatolla Robert 
Published: December 2024

ABSTRACTThree new probe-based quantitative PCR assays were designed based on Chaeet al. (2017),Pérez-Osorio et al.(2012), and Saleset al. (2012) to quantitateMycobacterium tuberculosiscomplex (MTBC) species,M. tuberculosis(MTB), andM. bovis(MB) in wastewater targeting genomic regionsrv0577,RD9, and the deletion of RD4, respectively. The assays were validated for specificity using four Mycobacterial species, including two MTBC species and two non-tuberculosis Mycobacteria species, and endogenous wastewater samples from Ottawa, Ontario, Canada, Mumbai, India, and a remote Northern Indigenous community in Nunangat with known ongoing tuberculosis cases or outbreaks. The three assays demonstrate high sensitivity and are suitable for use in wastewater. Partitioning experiments performed on endogenous MTBC and MTB in collected wastewaters from Mumbai, India with known tuberculosis outbreaks show that the targeted genomic regions ofrv0577(MTBC) and RD9 (MTB) used to quantitate human tuberculosis infection predominately partition to solids fraction of wastewaters. The partitioning results of this study, in combination with the presented probe-based PCR assays, provide guidance on how to best enrich wastewaters and rapidly and economically quantify tuberculosis with high specificity and sensitivity in wastewaters.GRAPHICAL ABSTRACT
The role of hedonic liking of new food on emotions: a laboratory study on insect snacks with young Italian participants
Authors: Proi Migena , Di Mattia Carla , Sacchetti Giampiero , Battista Natalia , Cozzolino Silvia , Nucci Pierluigi , Serafini Mauro , Perito Maria Angela 
Published: December 2024

PurposeThis study investigates the relationship between the hedonic pleasure of trying new food and emotional responses to insect-based bakery products.Design/methodology/approachA laboratory tasting was conducted with 131 Italian high school students in the province of Teramo (Italy). Participants completed a questionnaire to assess their general hedonic liking of new food and ranked the intensity of negative and positive emotions after tasting the food products.FindingsThe findings show that general hedonic liking of new food significantly influences both negative and positive emotions. In the case of negative emotions, individuals who declared to like trying new food were more likely to experience lower levels of disgust, fearful, worry and distrustful. Meanwhile, in the case of positive emotions, individuals who liked trying new food had a greater probability of feeling higher levels of calm, energy, enthusiasm and contentment. We further found that women were more likely to experience negative emotions (i.e. disgust, fearful and worry) to a higher extent than men.Practical implicationsThe results add useful information about food and marketing research by showing which emotions should be encouraged or avoided in the case of consumers with different degrees of liking new food.Originality/valueThis study is the first to assess how hedonic liking impacts emotions in the case of an insect-based food.
Corporate social responsibility and sustainable development goals in higher education: a literature review from 2014 to 2023
Authors: Gallardo-Vázquez Dolores , Sánchez-Domínguez Juan de la Cruz , Valdez-Juárez Luis Enrique 
Published: December 2024

Purpose
Corporate social responsibility (CSR) and the sustainable development goals (SDGs) have multiple interactions with higher education institutions (HEIs), and CSR strategies present a remarkable importance for companies and society, being necessary for universities to provide teaching and research within this topic. The purpose of this paper is to analyze the practical implications of the implementation of sustainability concepts in HEIs and, by extension, in society.

Design/methodology/approach
A sample formed by papers obtained from WoS (Web of Science) and Scopus databases was used (34 papers from WoS and 30 papers from Scopus). Both bibliometric and content analysis were performed to better understand the main characteristics of the sample, such as the most prolific countries and universities, as well as the main practical implications of each of the 64 papers analyzed.

Findings
The findings show the state of the art of the literature about sustainability and responsible management education published between 2014 and 2023. This paper also reports results like the most prolific authors and universities, the most cited papers and authors and the yearly production of papers, among other data. Implementing CSR and sustainability courses in HEIs curricula has a plurality of practical implications for businesses, the academic institutions and for society.

Research limitations/implications
The sample is limited because it is formed of papers written in English only, and that affects the productivity figures of both Spanish and Latin American universities. Having used a single piece of software for bibliometric analysis also limits the scope and depth of the results.

Practical implications
By analyzing a sample of 64 papers with different practical implications, this paper offers important data and practical ideas for HEIs to implement sustainability and responsible management education in their curricula, as well as of University Social Responsibility (USR) practices implementation. The paper also offers some insight into practical experiences with sustainability education for both undergraduate and graduate students, as well as advice for policymakers.

Originality/value
The paper’s originality and value are trifold: First, it links CSR and the SDGs with HEIs. Second, it combines a bibliometric analysis with a content analysis, creating added value for the research. And third, this paper studies the effect of the impact of CSR both in HEIs and in society.
The organizational consultant’s role in school improvement
Authors: Amossi Heli , Tubin Dorit 
Published: December 2024

PurposeThe involvement of organizational development (OD) consultants in schools has become widespread in recent years. In Israel, their presence increased in the past 2 decades when the Ministry of Education encouraged their entry as support for the self-management reform and improvement of failing schools. Despite accumulated experience and the research literature, little is known about their work patterns and how they contribute to school improvement. Therefore, our main research question is what they do and how their actions contribute to the school. We investigated this question based on an innovative conceptual framework that combines the focus of organizational intervention (individual, group and organization) and professional skills (diagnosis, intervention and inference).Design/methodology/approachSemi-structured interviews were conducted with 15 Israeli OD consultants, and content analysis revealed a total of 86 consulting events.FindingsThe findings of this study show significant events at individual and group levels, and only a few at the organization level. It was also found that while all the events focused on intervention, very few presented the professional skills of diagnosis and inference. We conclude that while the involvement of OD consultants in schools might contribute to immediate relief for the educational staff and to the symbolic appearance of rational management, their contribution to school improvement is still uncertain. Further theoretical and practical implications are discussed.Originality/valueThe conceptual framework of organizational level and professional skills bridges the gap between organizational development goals and the professional skills needed to implement these goals, indicating areas that require further theoretical and practical development.
Impact of social capital on business performance women entrepreneurs in the food sector: the moderating role of national culture
Authors: Paul Saima , Amin Faseeh 
Published: December 2024

PurposeThe role of women entrepreneurs in the food industry is becoming increasingly significant, as this sector is dynamic and competitive. This study seeks to enhance theoretical comprehension by assessing the role of social capital on business performance through mediating role of network resources and moderating role of national culture.Design/methodology/approachThe researchers have employed a cross-sectional causal design for this analysis. This research methodology enables us to examine the intricate interrelationships among several variables in the domain of female entrepreneurs in the food industry. The study included 403 female entrepreneurs actively engaged in the food industry.FindingsThe results indicate that a firm's internal and external social capital investments positively influence network resource acquisition. In addition, network resource acquisition positively affects business performance in women-led food enterprises and mediates the relationship between social capital and business performance. Moreover, national culture moderates the association between social capital and business performance.Research limitations/implicationsThe study is limited by its narrow focus on the food sector industry and its restriction to the geographic location of India, hence reducing its generalizability.Originality/valueThis study significantly contributes to the existing body of knowledge in entrepreneurship and social network research. This study deviates from previous research by introducing a strategic intermediate variable called network resource acquisition between social capital and business performance. Moreover, the moderating role of national culture, which has been understudied in previous works, has also been examined in the proposed research framework.
Navigating the change: exploring emotions, psychological safety and organizational support in the transition to home working – insights from the MENA region
Authors: Serhan Carole , Abdo Roger , Iskandar Dia , Gharib Michel 
Published: December 2024

PurposeThis study aims to explore emotions, psychological safety and organizational support in the workplace when transitioning from office to home-based work. By providing detailed descriptions of emotional reactions to this change, the study examines how organizational support might influence employees’ sense of psychological safety.Design/methodology/approachTo analyze the data, a qualitative data analysis was applied through using thematic coding. Data were collected by conducting structured telephone interviews with participants. These interviews included open-ended questions. Employees from both public and private companies in the MENA region were invited to take part in the study. The participants included full-time, part-time and contractual employees from different industries. In total, 112 participants were included in the final sample.FindingsThe results indicate that when workplaces change, emotions are triggered by comparing oneself to others and having the necessary socioemotional resources. Employees’ emotional reactions are influenced by how they perceive organizational support, which affects their psychological safety. Specifically, comparing to colleagues in lower positions activates emotions like pride, empathy and support (downward social comparison emotion), while comparing to top management decisions elicits emotions like anxiety, stress, unfairness, inferiority and vulnerability (upward social comparison emotion).Originality/valueThe findings of this research shed light on how emotions arise from social comparison when workplaces undergo changes as well as the different socioemotional resources present within groups. Not much research has focused on core and periphery groups in this context. This study helps fill that gap in our understanding.
Beyond the “like” button: ideal social self-congruity’s role in shaping consumer behaviors on social media
Authors: Zhu Jiang , Jiang Lan , Dou Wenyu , Wang Valerie Lynette , Zhou Liying 
Published: December 2024

PurposeThis study leverages theories of social influence to explore how “likes” for consumption-related content on social media fulfill consumers’ needs for social acceptance, subsequently affecting their repurchase and word-of-mouth (WOM) intentions. It aims to understand the extent to which social media engagements, specifically likes, serve as markers of social validation in the context of consumer behavior.Design/methodology/approachOur mixed-methods approach incorporated two experiments and an analysis of an archival dataset from a popular Chinese social media platform. This comprehensive methodology allowed for empirical validation of our hypotheses, combining experimental control with real-world relevance to scrutinize the impact of likes on consumption behavior.FindingsThe results of Studies 1 and 2 revealed that the number of likes significantly enhanced behavioral intentions regarding repurchase and positive word-of-mouth by fulfilling consumers’ need for social acceptance. Moreover, this effect was observed only under conditions of high (vs low) ideal social self-congruity. Study 3, conducted in a natural social media context, further validated these findings, demonstrating that likes positively influenced behavioral intention, with ideal social self-congruity acting as a boundary condition.Originality/valueThis study provides a novel perspective by directly linking social media likes to consumer behavioral intentions, specifically repurchase and WOM, through the mediating role of social acceptance and the moderating effect of ideal social self-congruity. By focusing on user-generated content (UGC) rather than marketer-generated content (MGC), it addresses a critical gap in the literature, emphasizing how receiving likes on consumer-shared content impacts content creators’ post-purchase behaviors, with practical implications for marketers on leveraging aspirational self-congruity to optimize promotional strategies.
Drink spiking? A case study of a university student and the impact of uncertainty and personal safety when drinking alcohol on THAT Friday night
Authors: Hughes Ben 
Published: December 2024

Purpose
Nearly half of 18–24-year-olds report drink spiking on themselves or someone they know. However, this is an under-researched topic and nearly all previous studies have focused on women. This study aims to help understand a possible spiking incident from a male perspective.

Design/methodology/approach
An individual case study methodology, using a reflective account from a young male university student, was used to provide a personal interpretation of an incident at the university.

Findings
Abnormal changes in behaviour and cognition were out of character and corresponded with spiking but were explained by paramedics and some friends as a result of excessive alcohol.

Originality/value
For the first time, this paper explores and helps understand the very personal and individual responses of a young male who was a likely spiking victim, providing the confusion, embarrassment and uncertainty of the situation. In addition, this situation highlights the need for personal vigilance while on a night out, as well as the training needs for emergency responders and nighttime staff and the understanding from friends and observers.
Numerical exploration of bioconvection in optimizing nanofluid flow through heated stretched cylinder in existence of magnetic field
Authors: Galal Ahmed M. , Zeemam Muhammad , Imran Muhammad , Basit Muhammad Abdul , Tahir Madeeha , Akram Saima , Younis Jihad 
Published: December 2024

PurposeNanofluids are used in technology, engineering processes and thermal exchanges. In thermal transfer processing, these are used for the smooth transportation of heat and mass through various mechanisms. In the current investigation, we have examined multiple effects like activation energy thermal radiation, magnetic field, external heat source and especially slippery effects on a bioconvective Casson nanofluid flow through a stretching cylinder.Design/methodology/approachSeveral studies used non-Newtonian fluid models to study blood flow in the cardiovascular system. In our research, Lewis numbers for bioconvection and the influence of important parameters, such as Brownian diffusion and thermophoresis effects, are also considered. This system is developed as a partial differential equation for the mathematical treatment. Well-defined similarity transformations convert partial differential equation systems into ordinary differential equations. The resultant system is then numerically solved using the bvp4c built-in function of MATLAB.FindingsAfter utilizing the numerical approach to the system of ordinary differential equations (ODEs), the results are generated in the form of graphs and tables. These generated results show a suitable accuracy rate compared to the previous results. The consequence of various parameters under the assumed boundary conditions on the temperature, motile microorganisms, concentration and velocity profiles are discussed in detail. The velocity profile decreases as the Magnetic and Reynolds number increases. The temperature profile exhibits increasing behavior for the Brownian motion and thermal radiation count augmentation. The concentration profile decreased on greater inputs of the Schmidt number and magnetic effect. The density of motile microorganisms decreases for the increased value of the bio-convective Lewis number.Originality/valueThe numerical analysis of the flow problem is addressed using graphical results and tabular data; our reported results are refined and novel based on available literature. This method is useful for addressing such fluidic flow efficiently.