bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on Sloshing Effect of Vertical Storage Tank With Displacement Seismic Excitation
Authors: Cui Lifu , Sun Jiangang , Liu Weibing , Wang Zhen , Li Xiang 
Published: August 2020

Abstract
A 1:4 scale seismic simulation shaking table experiment was designed and performed to study the sloshing wave height response of a storage tank under displacement due to seismic excitation, wherein a 1000 m3 vertical storage tank was used to compare the sloshing wave height for different tanks with different foundations. Under different foundation forms, the tank motion includes sway and roll. Meanwhile, the design code and finite element method were used to compare with the experiment for mutual verification. The results show that the peak value of the sloshing wave height is at its minimum at the center, and the maximum is near the tank wall when the model tank was excited to the ground motion with the predominant frequency range from 0.29 and 0.32 Hz, and the floating roof can significantly reduce the sloshing wave height. For different input conditions with equivalent seismic magnitude, the wave heights were notably different, so the design should use multiple seismic waves as inputs. The acceleration values were different when different foundations were used, but there was little effect on the sloshing wave height. Besides, the sloshing wave heights measured in the experiment were close to those calculated using standard equations and finite element results, which proves that the three can verify each other.
Experimental Study of the Hydraulic Performances of Two Three-Bladed Inducers in Water, Water With Dissolved CO2, and Jet Fuel
Authors: Magne Théodore , Paridaens Richard , Khelladi Sofiane , Bakir Farid , Tomov Petar , Pora Loic 
Published: August 2020

Abstract
Inducers in centrifugal pumps are generally placed upstream to increase the pressure before the impeller and prevent cavitation occurrence. Their general goal is to obtain a positive impact on the performances of a pump in a two-phase regime. Cavitation phenomenon has been the subject of many studies; however, the influence of the presence of dissolved gas in the liquid pumped under particular operating conditions remains not sufficiently explored. To the best of our knowledge, aviation jet fuel cavitation is moderately documented. In the present work, we conducted an experimental study on two three-bladed axial inducers at partial flow rates only in cavitating and noncavitating regimes. The experimental work used aviation jet fuel, water, and water with dissolved content of CO2 at constant temperature in two closed loops with transparent test sections. In one tank, a specific device is placed to inject a controlled quantity of CO2 and to dissolve it in water. We achieved a comparison of the flow dynamics through the use of a high-speed camera with a sampling rate of 1000 Hz. The results show inducers' water–CO2 cavitation performances to be in good agreement with aviation jet fuel cavitation results.
Experimental Flow-Induced Motions of a FOWT Semi-Submersible Type (OC4 Phase II Floater)
Authors: Gonçalves Rodolfo T. , Chame Maria E. F. , Silva Leandro S. P. , Koop Arjen , Hirabayashi Shinichiro , Suzuki Hideyuki 
Published: August 2020

Abstract
Flow-induced motions (FIM) are an issue for floating offshore structures, such as multi-column platforms, as the phenomenon can decrease the fatigue life of the mooring, riser, and cable systems. The new concept of floating offshore wind turbines (FOWT) have a multi-column design that may be subjected to FIM. In the past, FIM was studied mainly for Oil & Gas platforms installed in deep waters. However, the FIM phenomenon of FOWT has been insufficiently explored. To rectify this, model tests were performed for the semisubmersible (SS) floating system design developed for the DeepCwind project (Offshore Code Comparison Collaboration Continuation (OC4) phase II). This paper will investigate the presence of FIM and show its importance in the design process of FOWT. Three different incidence angles of the current were tested, namely, 0, 90, and 180 deg. For each heading, 30 reduced velocities were tested, across the range 8000 &lt; Re &lt; 70,000. The results showed amplitudes in the transverse direction of around 70% of the diameter of the platform column, which is similar to those observed for deep-draft (DD) SS with circular columns. Note that these amplitude values are larger for a floater with a circular column, than for a platform with square columns. The results showed that as FIM occurred for this specific FOWT SS, its effect has to be considered in the mooring system and electric cable design.
Does Fibre-fix provided to people with irritable bowel syndrome who are consuming a low FODMAP diet improve their gut health, gut microbiome, sleep and mental health? A double-blinded, randomised controlled trial
Authors: Yan Ran , Murphy Mandy , Genoni Angela , Marlow Evania , Dunican Ian C , Lo Johnny , Andrew Lesley , Devine Amanda , Christophersen Claus T 
Published: August 2020

IntroductionA diet low in fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) is an effective way to reduce gut symptoms in people with irritable bowel syndrome (IBS). This diet reduces the intake of fermentable fibres, leading to changes of the gut microbiota and insufficient fermentation in the large bowel, resulting in reduced production of short-chain fatty acids (SCFAs), such as butyrate, which has unfavourable implications for gut health, sleep and mental health. This study will examine the effect of Fibre-fix, a supplement containing a mix of dietary fibres, on the human gut microbiome composition, fermentative capacity, sleep, quality of life (QOL) and mental health of people with IBS who consume a low FODMAP diet (LFD).Methods and analysisA randomised, double-blind, placebo-controlled, study design is proposed to examine whether Fibre-fix added to an existing LFD may help modulate gastrointestinal function, improve markers of sleep, mental health and promote QOL in patients with IBS. Participants will provide stool and blood samples, daily bowel symptoms diaries and 3-day diet records. Additionally, they will complete validated questionnaires relating to FODMAP intake, sleep, mental health and QOL before and after a 3-week intervention. Gut health will be assessed via faecal microbiome composition, faecal pH and SCFA levels. Alteration of sleep will be recorded using an actigraphy device worn by all participants over the whole study. Multivariate analysis will be used to examine the gut microbiome and repeated measures Analysis of variance (ANOVA) will be used for dependent variables from questionnaires related to bowel symptoms, stool type, sleep, mental health and QOL to assess the differences between intervention and control groups after adjustment for confounding variables.Ethics and disseminationEthics approval was obtained from the Human Research Ethics Committee of Edith Cowan University (2019-00619-YAN). Results will be disseminated in peer-review journal publications, and conference presentations. Participants will be provided with a summary of findings once the study is completed. If Fibre-fix is shown to result in favourable changes in gut microbial composition, SCFA production, sleep and mental well-being without exacerbating symptoms, this will provide additional dietary management options for those with IBS following an LFD.Trial registration numberACTRN12620000032954.
Distal feeding–bowel stimulation to treat short-term or long-term pathology: a systematic review
Authors: Dilke Stella Maye , Gould Laura , Yao Mark , Souvatzi Maria , Stearns Adam , Ignjatovic-Wilson Ana , Tozer Phil , Vaizey Carolynne J 
Published: August 2020

BackgroundDistal feeding (DF) describes the insertion of a feeding tube into a fistula or stoma to administer a liquid feed into the distal bowel. It is currently used clinically in patients who are unable to absorb enough nutrition orally. This systematic review investigates DF as a therapeutic measure across a spectrum of patients with stomas and fistulae.MethodsA total of 2825 abstracts and 44 full-text articles were screened via OVID. Fifteen papers were included for analysis. Randomised controlled trials, cohort and observational studies investigating DF as a therapeutic measure were included.ResultsThree feeds were used across the studies—reinfusion of effluent, infusion of prebiotic or a mixture. The studies varied the length of feeding between 24 hours and 61 days, and the mode of feeding, bolus or continuous varied.DF was demonstrated to effectively wean patients from parenteral nutrition in two papers. Two papers demonstrated a significant reduction in stoma output. Three papers demonstrated improved postoperative complication rates with distal feeding regimens, including ileus (2.85% vs 20% in unfed population, p=0.024). One paper demonstrated a reduction in postoperative stool frequency.ConclusionsThis review was limited by study heterogeneity and the lack of trial data, and in the patient groups involved, the variability in diet and length of regimen. These studies suggest that DF can significantly reduce stoma output and improve renal and liver function; however, the mechanism is not clear. Further mechanistic work on the immunological and microbiological action of DF would be important.
Gastrointestinal manifestations of COVID-19 in children: a systematic review and meta-analysis
Authors: Akobeng Anthony K , Grafton-Clarke Ciaran , Abdelgadir Ibtihal , Twum-Barimah Erica , Gordon Morris 
Published: August 2020

ObjectivesTo summarise the published evidence on the gastrointestinal manifestations of COVID-19 in children and to determine the prevalence of gastrointestinal symptoms.MethodsIn this systematic review and meta-analysis, we searched PubMed, Embase, CINAHL and the WHO’s database of publications on novel coronavirus. We included English language studies that had described original demographic and clinical characteristics of children diagnosed with COVID-19 and reported on the presence or absence of gastrointestinal symptoms. Meta-analysis was conducted using the random-effects model. The pooled prevalence of gastrointestinal symptoms was expressed as proportion and 95% CI.ResultsThe search identified 269 citations. Thirteen studies (nine case series and four case reports) comprising data for 284 patients were included. Overall, we rated four studies as having a low risk of bias, eight studies as moderate and one study as high risk of bias. In a meta-analysis of nine studies, comprising 280 patients, the pooled prevalence of all gastrointestinal symptoms was 22.8% (95% CI 13.1% to 35.2%; I2=54%). Diarrhoea was the most commonly reported gastrointestinal symptom followed by vomiting and abdominal pain.ConclusionsNearly a quarter of children with COVID-19 have gastrointestinal symptoms. It is important for clinicians to be aware of the gastrointestinal manifestation of COVID-19.PROSPERO registration numberCRD42020177569.
Histopathological observations in COVID-19: a systematic review
Authors: Deshmukh Vishwajit , Motwani Rohini , Kumar Ashutosh , Kumari Chiman , Raza Khursheed 
Published: August 2020

BackgroundCoronavirus disease-2019 (COVID-19) has caused a great global threat to public health. The World Health Organization (WHO) has declared COVID-19 disease as a pandemic, affecting the human respiratory and other body systems, which urgently demands for better understanding of COVID-19 histopathogenesis.ObjectiveData on pathological changes in different organs are still scarce, thus we aim to review and summarise the latest histopathological changes in different organs observed after autopsy of COVID-19 cases.Materials and methodsOver the period of 3 months, authors performed vast review of the articles. The search engines included were PubMed, Medline (EBSCO & Ovid), Google Scholar, Science Direct, Scopus and Bio-Medical. Search terms used were ‘Histopathology in COVID-19’, ‘COVID-19’, ‘Pathological changes in different organs in COVID-19’ or ‘SARS-CoV-2’. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2009 guidelines were used for review writing.ResultWe identified various articles related to the histopathology of various organs in COVID-19 positive patients. Overall, 45 articles were identified as full articles to be included in our study. Histopathological findings observed are summarised according to the systems involved.ConclusionAlthough COVID-19 mainly affects respiratory and immune systems, but other systems like cardiovascular, urinary, gastrointestinal tract, reproductive system, nervous system and integumentary system are not spared, especially in elderly cases and those with comorbidity. This review would help clinicians and researchers to understand the tissue pathology, which can help in better planning of the management and avoiding future risks.
Efficacy and safety of adjunctive lacosamide in the treatment of primary generalised tonic-clonic seizures: a double-blind, randomised, placebo-controlled trial
Authors: Vossler David G , Knake Susanne , O'Brien Terence J , Watanabe Masako , Brock Melissa , Steiniger-Brach Björn , Williams Paulette , Roebling Robert 
Published: August 2020

ObjectiveTo evaluate efficacy and safety of lacosamide (up to 12 mg/kg/day or 400 mg/day) as adjunctive treatment for uncontrolled primary generalised tonic-clonic seizures (PGTCS) in patients (≥4 years) with idiopathic generalised epilepsy (IGE).MethodsPhase 3, double-blind, randomised, placebo-controlled trial (SP0982;NCT02408523) in patients with IGE and PGTCS taking 1–3 concomitant antiepileptic drugs. Primary outcome was time to second PGTCS during 24-week treatment.Results242 patients were randomised and received ≥1 dose of trial medication (lacosamide/placebo: n=121/n=121). Patients (mean age: 27.7 years; 58.7% female) had a history of generalised-onset seizures (tonic-clonic 99.6%; myoclonic 38.8%; absence 37.2%). Median treatment duration with lacosamide/placebo was 143/65 days. Risk of developing a second PGTCS during 24-week treatment was significantly lower with lacosamide than placebo (Kaplan-Meier survival estimates 55.27%/33.37%; HR 0.540, 95% CI 0.377 to 0.774; p<0.001; n=118/n=121). Median time to second PGTCS could not be estimated for lacosamide (>50% of patients did not experience a second PGTCS) and was 77.0 days for placebo. Kaplan-Meier estimated freedom from PGTCS at end of the 24-week treatment period (day 166) for lacosamide/placebo was 31.3%/17.2% (difference 14.1%; p=0.011). More patients on lacosamide than placebo had ≥50% (68.1%/46.3%) or ≥75% (57.1%/36.4%) reduction from baseline in PGTCS frequency/28 days, or observed freedom from PGTCS during treatment (27.5%/13.2%) (n=119/n=121). 96/121 (79.3%) patients on lacosamide had treatment-emergent adverse events (placebo 79/121 (65.3%)), most commonly dizziness (23.1%), somnolence (16.5%), headache (14.0%). No patients died during the trial.ConclusionsLacosamide was efficacious and generally safe as adjunctive treatment for uncontrolled PGTCS in patients with IGE.
Follow-up outcomes of intracranial aneurysms treated using braided or laser-cut stents with closed-cell design: a propensity score-matched case-controlled comparison
Authors: Lim JeongWook , Cho Young Dae , Hong Noah , Lee Jeongjun , Yoo Dong Hyun , Kang Hyun-Seung 
Published: August 2020

BackgroundThe impact of various stents on patients with intracranial aneurysms who undergo stent-assisted coiling has been debated. We conducted this study to compare follow-up outcomes of coiling procedures involving braided or laser-cut stents with closed-cell design. A propensity score-matched case-controlled analysis was applied.MethodsA total of 413 intracranial aneurysms consecutively coiled using laser-cut (n=245) or braided stents (n=168) in procedures performed between September 2012 and June 2017 were eligible for study. Time-of-flight magnetic resonance angiography, catheter angiography, or both were used to gauge occlusive status after coiling. Recanalization was determined by Raymond classification (complete occlusion vs recanalization). A propensity score-matched analysis was conducted, based on probability of stent type in use.ResultsUltimately, 93 coiled aneurysms (22.5%) showed some recanalization (minor, 51; major, 42) during the follow-up period (mean 21.7±14.5 months). Patient gender (P=0.042), hyperlipidemia (P=0.015), size of aneurysm (P=0.004), neck size (P<0.001), type of aneurysm (P<0.001), and packing density (P=0.024) differed significantly by group. Midterm and cumulative recanalization incidence rates in the braided-stent group were initially lower than those of the laser-cut stent group (P=0.009 and P=0.037, respectively) but they did not differ significantly after 1:1 propensity score matching (midterm OR=0.88, P=0.724; cumulative HR=0.91, P=0.758).ConclusionIn stent-assisted coiling of intracranial aneurysms, laser-cut and braided stent groups produced similar outcomes in follow-up. Consequently, product selection may hinge on suitability for deployment rather than anticipated results.
Influence of feedlot manure amendments on dissolved organic carbon in runoff during transition from continuous to legacy applications
Authors: Miller J.J. , Beasley B.W. , Owen M.L. , Hao X. , Drury C.F. , Chanasyk D.S. 
Published: August 2020

Little research has compared land application of stockpiled (SM) or composted (CM) beef feedlot manure with straw (ST) or wood-chip (WD) bedding on loss of dissolved organic carbon (DOC) in runoff. We conducted a 6 yr (2013–2018) rainfall simulation-runoff study and utilized surface (0–5 cm) soil collected from a long-term (since 1998) field experiment on a clay loam soil in southern Alberta, Canada. The treatments consisted of SM or CM with ST or WD bedding applied at 13, 39, and 77 Mg·ha−1 (dry weight), as well as an unamended control and mineral fertilizer treatment. Surface soil was collected from all treatments after 15–17 (C15, C16, and C17; 2013–2015) continual annual applications and then after one to three legacy years (L1–L3, 2016–2018) after manure applications were first discontinued in 2015. The soil was packed into runoff trays, and flow-weighted mean concentrations (FWMCs) and mass loads of DOC in runoff water were determined during rainfall simulations. Mean DOC losses were generally significantly (P ≤ 0.05) lower for CM with ST bedding compared with the other manure type – bedding treatments in certain years and were consistent with this amendment having the lowest total carbon (C) content. The total C content of the amendments explained 92% of the variation in DOC concentration. Termination of long-term manure applications reduced FWMCs by 85%–91% and mass loss by 76%–89% from the C17 to L3 year. Therefore, our findings suggested that composting manure with ST or discontinued long-term manure application may reduce DOC loss in runoff.
Simple FFH pilot experiment model based on DTT-like machine
Authors: Panza F. , Balog I. , Cemmi A. , Di Sarcina I. , Filippi F. , Mansi E. , Orsitto F. P. , Osipenko M. , Ricco G. , Ripani M. , Ciotti M. 
Published: August 2020

AbstractThe global need for energy in the world is constantly increasing. Critical fission reactors have proved great efficiency in the energy production, but the fear of nuclear wastes and accidents due to an uncontrolled chain reaction makes these unpleasant to public. More safe fusion reactors, on the opposite, have low efficiency. Hybrid reactors capable of using the advantages of both are studied, but not yet developed. In this paper, a simple fusion–fission pilot experiment model has been developed. A Tokamak with the same characteristics of DTT (Divertor Tokamak Test facility) has been considered as a reference machine for the fusion component. The fusion system has been coupled with a relatively simple low-power fission blanket configured into three different modes by using different fuels and materials. This model could be useful in order to investigate the properties of the fusion–fission hybrid coupling from a neutronic point of view.
Molecular and Immunologic Signatures are Related to Clinical Benefit from Treatment with Vocimagene Amiretrorepvec (Toca 511) and 5-Fluorocytosine (Toca FC) in Patients with Glioma
Authors: Accomando William P. , Rao Aliz R. , Hogan Daniel J. , Newman Aaron M. , Nakao Aki , Alizadeh Ash A. , Diehn Maximilian , Diago Oscar R. , Gammon Dawn , Haghighi Ali , Gruber Harry E. , Jolly Douglas J. , Ostertag Derek 
Published: August 2020

Abstract

Purpose:
High-grade gliomas (HGGs) are central nervous system tumors with poor prognoses and limited treatment options. Vocimagene amiretrorepvec (Toca 511) is a retroviral replicating vector encoding cytosine deaminase, which converts extended release 5-fluorocytosine (Toca FC) into the anticancer agent, 5-fluorouracil. According to preclinical studies, this therapy kills cancer cells and immunosuppressive myeloid cells in the tumor microenvironment, leading to T-cell–mediated antitumor immune activity. Therefore, we sought to elucidate this immune-related mechanism of action in humans, and to investigate potential molecular and immunologic indicators of clinical benefit from therapy.

Patients and Methods:
In a phase I clinical trial (NCT01470794), patients with recurrent HGG treated with Toca 511 and Toca FC showed improved survival relative to historical controls, and some had durable complete responses to therapy. As a part of this trial, we performed whole-exome DNA sequencing, RNA-sequencing, and multiplex digital ELISA measurements on tumor and blood samples.

Results:
Genetic analyses suggest mutations, copy-number variations, and neoantigens are linked to survival. Quantities of tumor immune infiltrates estimated by transcript abundance may potentially predict clinical outcomes. Peak values of cytokines in peripheral blood samples collected during and after therapy could indicate response.

Conclusions:
These results support an immune-related mechanism of action for Toca 511 and Toca FC, and suggest that molecular and immunologic signatures are related to clinical benefit from treatment.
Relações intersubjetivas em “extrair”, de Arnaldo Antunes
Authors: Souza Paula Martins de 
Published: August 2020

Este artigo visa a apresentar mecanismos de significação que estão por trás de relações intersubjetivas dos textos. A metodologia empregada tem por base, por um lado, a Semiótica de linha francesa, notadamente as contribuições de Greimas, Zilberberg, Fiorin e Tatit. Por outro lado, a metodologia nutre-se da segunda tópica freudiana e da matriz intersubjetiva de Coelho Jr. e Figueiredo. Greimas contribui com o percurso gerativo do sentido, no plano do conteúdo, além da postulação de sua junção com o plano da expressão. Zilberberg auxilia com a revisão do nível mais abstrato da significação, além da oposição entre os valores de absoluto, de universo, de apogeu e de abismo. Fiorin provê a distinção entre os sujeitos do discurso. Tatit fornece sua praxeologia, que permitirá proceder a uma oposição entre diferentes modos enunciativos de fazer e, com isso, de estatuir o ser do enunciador, além de uma releitura do acontecimento greimasiano. A essas contribuições, acrescento uma oposição entre os campos objetivo e subjetivo, que organiza interações entre tipos diferentes de sujeito. O poema “extrair”, de Arnaldo Antunes, foi escolhido para a demonstração desses mecanismos de significação. Como resultado, a análise possibilitou compreender o arranjo intersubjetivo que está por trás da configuração de sujeito insurgente do narrador do poema