bluuebunny/crossref_metadata_2025_split huggingface dataset:
o-Hydroxycinnamic derivatives as prospective anti-platelet candidates:in silicopharmacokinetic screening and evaluation of their binding sites on COX-1 and P2Y12receptors
Authors: Nofianti Kholis Amalia , Ekowati Juni 
Published: December 2019

AbstractBackgroundThe high prevalence of thrombotic abnormalities has become a major concern in the health sector. This is triggered by uncontrolled platelet aggregation, which causes complications and death. The problem becomes more complicated because of the undesirable side effects of the drugs currently in use, some of which have reportedly become resistant. This study aims to evaluate the potency ofo-hydroxycinnamic acid derivatives (OCA1a–22a) and their pharmacokinetic properties and toxicity for them to be developed as new antiplatelet candidates.MethodsIn silicoanalysis of pharmacokinetics was carried out using pKCSM. Molecular docking of the compounds OCA 1a–22a was performed using the Molegro Virtual Docker.In silicoevaluation of the potency of biological activity was done by measuring the bonding energy of each tested compound to the target receptor i.e. COX-1 and P2Y12, as the Moldock score (MDS).ResultspKCSM analyses showed that more than 90% of OCA 1a–22a are absorbed through the intestine and distributed in plasma. Most tested compounds are not hepatotoxic, and none is mutagenic. An evaluation of the COX-1 receptor showed that OCA 2a–22a have lower binding energy compared to aspirin, which is the COX-1 inhibitor used today. So, it can be predicted that OCA 2–22a have stronger activity. Interactions with P2Y12show lower MDS than aspirin, but slightly higher than ibuprofen, which is the standard ligand.ConclusionsADMET (absorption, distribution, metabolism, excretion, and toxicity) profile prediction shows that OCA 1a–22a have the potential to be developed as oral preparations. OCA 1a–22a have strong potential to interact with COX-1 and P2Y12receptors, so they are prospective anti-platelet candidates.
Factors affecting community pharmacist’s service for women with chronic diseases during pregnancy and breastfeeding: application of the Health Belief Model
Authors: Anggraini Septi , Utami Wahyu , Zairina Elida 
Published: December 2019

Abstract

Background
Pharmacists are known as health care professionals who are responsible for the safety and efficacy of medicine to achieve optimal therapeutic results. Community pharmacists have an opportunity to provide direct services including giving an active medication information service in women during pregnancy and breastfeeding. This study aimed to determine the factors associated with the practice of community pharmacists for actively giving the drug information service for women with chronic diseases during pregnancy and breastfeeding based on the Health Belief Model.

Methods
About 300 community pharmacists were randomly chosen to participate in the study. All participants were asked to complete questionnaires that were designed based on the theory of the Health Belief Models. The questionnaires measured the community pharmacists’ knowledge, beliefs, cues to action, and practice for actively giving medication information services.

Results
About 267 pharmacists in the community agreed to participate in this study. Nearly 80% of the participants were female pharmacists (n = 213). The results show that pharmacists’ knowledge had significant influences towards perceived threat (p = 0.009), perceived benefit (p = 0.011), and pharmacists’ self-efficacy (p < 0.001). The self-efficacy factor was the most influential factor in the practice of pharmacists to give medication information service actively (p < 0.001).

Conclusions
The findings of the study indicate that self-efficacy is the most important factor for pharmacist to be able to provide the medication information services successfully particularly in women during pregnancy and breastfeeding. Providing continuous learning programs through seminars and training related to medication use during pregnancy and breastfeeding to pharmacists is needed to optimise the confidence and the ability of pharmacists in providing the services.
Recovering differential operators with two constant delays under Dirichlet/Neumann boundary conditions
Authors: Vojvodic Biljana M. , Vladicic Vladimir M. 
Published: December 2019

Abstract
This paper deals with non-self-adjoint differential operators with two constant delays
generated by

-

y
′′

+

q
1

⁢

(
x
)

⁢
y
⁢

(

x
-

τ
1

)

+

(

-
1

)

i

⁢

q
2

⁢

(
x
)

⁢
y
⁢

(

x
-

τ
2

)

{-y^{\prime\prime}+q_{1}(x)y(x-\tau_{1})+(-1)^{i}q_{2}(x)y(x-\tau_{2})}

, where

π
3

≤

τ
2

<

π
2

<

2
⁢

τ
2

≤

τ
1

<
π

{\frac{\pi}{3}\leq\tau_{2}<\frac{\pi}{2}<2\tau_{2}\leq\tau_{1}<\pi}

and potentials

q
j

{q_{j}}

are real-valued functions,

q
j

∈

L
2

⁢

[
0
,
π
]

{q_{j}\in L^{2}[0,\pi]}

. We will prove that the delays and the potentials are uniquely determined from the spectra of four boundary value problems: two of them under boundary conditions

y
⁢

(
0
)

=

y
⁢

(
π
)

=
0

{y(0)=y(\pi)=0}

and the remaining two under boundary conditions

y
⁢

(
0
)

=

y
′

⁢

(
π
)

=
0

{y(0)=y^{\prime}(\pi)=0}

.
Standardization in biobanking – between cooperation and competition
Authors: Meinung Bettina , Martin Dunja , Zimmermann Uwe 
Published: December 2019

Abstract
This article presents the current situation of German biobanks and shows future fields of action in the European and international context on the basis of upcoming legal and normative challenges. It gives an overview of the development of the international biobank standard ISO 20387 and the commitment of German biobank experts in the ISO committee TC276. Less attention than the biobank standard per se has so far been paid to the basic mechanisms by which standards are developed and the potential of their application and accreditation. In this sense, this article deals with the motivation for active participation in standardization projects. We discuss the status of ISO 20387 as a conformity assessment standard and the consequence of accreditation as a performance monitor.
Strong coupling between organic dye molecules and lattice modes of a dielectric nanoparticle array
Authors: Heilmann Rebecca , Väkeväinen Aaro I. , Martikainen Jani-Petri , Törmä Päivi 
Published: December 2019

Abstract
Plasmonic structures interacting with light provide electromagnetic resonances that result in a high degree of local field confinement, enabling the enhancement of light-matter interaction. Plasmonic structures typically consist of metals, which, however, suffer from very high ohmic losses and heating. High-index dielectrics, meanwhile, can serve as an alternative material due to their low-dissipative nature and strong scattering abilities. We studied the optical properties of a system composed of all-dielectric nanoparticle arrays covered with a film of organic dye molecules (IR-792) and compared these dielectric arrays with metallic nanoparticle arrays. We tuned the light-matter interaction by changing the concentration in the dye film and reported the system to be in the strong coupling regime. We observed a Rabi splitting between the surface lattice resonances of the nanoparticle arrays and the absorption line of the dye molecules of up to 253 and 293 meV, for the dielectric and metallic nanoparticles, respectively. The Rabi splitting depends linearly on the square root of the dye molecule concentration, and we further assessed how the Rabi splitting depends on the film thickness for a low dye molecule concentration. For thinner films of thicknesses up to 260 nm, we observed no visible Rabi splitting. However, a Rabi splitting evolved at thicknesses from 540 to 990 nm. We performed finite-difference time-domain simulations to analyze the near-field enhancements for the dielectric and metallic nanoparticle arrays. The electric fields were enhanced by a factor of 1200 and 400, close to the particles for gold and amorphous silicon, respectively, and the modes extended over half a micron around the particles for both materials.
Progress and challenges in p-type oxide-based thin film transistors
Authors: Shang Zong-Wei , Hsu Hsiao-Hsuan , Zheng Zhi-Wei , Cheng Chun-Hu 
Published: December 2019

AbstractTransparent electronics has attracted much attention and been widely studied for next-generation high-performance flat-panel display application in the past few years, because of its excellent electrical properties. In display application, thin film transistors (TFTs) play an important role as the basic units by controlling the pixels. Among them, oxide-based TFTs have become promising candidates and gradually replaced the conventional amorphous and polycrystalline silicon TFTs, due to high mobility, good transparency, excellent uniformity and low processing temperature. Even though n-type oxide TFTs have shown high device performance and been used in commercial display application, p-type oxide TFTs with the equal performance have been rarely reported. Hence, in this paper, recent progress and challenges in p-type oxide-based TFTs are reviewed. After a short introduction, the TFT device structure and operation are presented. Then, recent developments in p-type oxide TFTs are discussed in detail, with the emphasis on the potential p-type oxide candidates as copper oxide, tin oxide and nickel oxide. Moreover, miscellaneous applications of p-type oxide TFTs are also presented. Despite this, the performance of p-type oxide TFTs still lags behind, as compared with that of n-type counterparts. Thus, the current issues and challenges of p-type oxide TFTs are briefly discussed.
Finite element nonlinear transient modelling of carbon nanotubes reinforced fiber/polymer composite spherical shells with a cutout
Authors: Lee Sang-Youl , Hwang Ji-Gwang 
Published: December 2019

Abstract
This study dealt with geometrically nonlinear transient behaviors of carbon nanotube/fiber/polymer composite (CNTFPC) spherical shells containing a central cutout. A multiscale analysis using the Hewitt and Malherbe model was performed to determine the carbon nanotube (CNT)weight ratios, thickness-radius ratios, thickness-length ratios of CNTs, and cutout sizes. Based on the first-order shear deformation plate theory (FSDT),the Newmark method and Newton-Raphson iteration were used for the nonlinear dynamic solution. The proposed approach in this study has been verified by previous studies. Parametric results showed the significance of a proper CNT ratio and curvature for better structural performance on the nonlinear dynamic behaviors of CNTFPC spherical shells with a cutout.
Luminescence of uranium(VI) after liquid-liquid extraction from HCl by Aliquat® 336 in n-dodecane:1-decanol by time-resolved laser-induced luminescence spectroscopy
Authors: Reiller Pascal E. , Mariet Clarisse 
Published: December 2019

Abstract
To investigate the extraction of uranium(VI) in HCl media by Aliquat® 336 in 1:99 (v:v) 1-decanol:n-dodecane mixture, our objective is to identify the complexe(s) in the organic phase by time-resolved laser-induced luminescence spectroscopy (TRLS). The extraction mechanism is supposed to involve the formation of

[
U

O
2

C

l
4

2
−

⋅

(

R
4

N
+

)

2

]

$[U{O_2}Cl_4^{2 - } \cdot {({R_4}{N^ + })_2}]$

in the organic phase. The occurrence of such a species leads to the presence of the

UO

2

Cl

4

2
−

${\rm{U}}{{\rm{O}}_2}{\rm{Cl}}_4^{2 - }$

species in the organic solution, which luminescence shows particular features. The luminescence spectra and decay time evolutions are obtained in the organic phase as a function of HCl concentration in the aqueous phase (0.5–6 M). The extraction of

UO

2

Cl

4

2
−

${\rm{U}}{{\rm{O}}_2}{\rm{Cl}}_4^{2 - }$

is confirmed by the particular spectrum of uranium(VI) in the organic phase, and the typical splitting of the luminescence bands, due to the crystal field effect, is clearly evidenced. The stoichiometry is verified using luminescence intensity variation as a function of the activity of Cl−, and extraction constants are calculated both using the specific interaction theory and Pitzer model. A decomposition of the spectrum of the extracted complex in the organic phase is also proposed. The decay time variation as a function of temperature allows estimating the activation energy of the luminescence process of the extracted complex.
Novel Bayesian Networks for Genomic Prediction of Developmental Traits in Biomass Sorghum
Authors: dos Santos Jhonathan P R , Fernandes Samuel B , McCoy Scott , Lozano Roberto , Brown Patrick J , Leakey Andrew D B , Buckler Edward S , Garcia Antonio A F , Gore Michael A 
Published: December 2019

Abstract
The ability to connect genetic information between traits over time allow Bayesian networks to offer a powerful probabilistic framework to construct genomic prediction models. In this study, we phenotyped a diversity panel of 869 biomass sorghum (Sorghum bicolor (L.) Moench) lines, which had been genotyped with 100,435 SNP markers, for plant height (PH) with biweekly measurements from 30 to 120 days after planting (DAP) and for end-of-season dry biomass yield (DBY) in four environments. We evaluated five genomic prediction models: Bayesian network (BN), Pleiotropic Bayesian network (PBN), Dynamic Bayesian network (DBN), multi-trait GBLUP (MTr-GBLUP), and multi-time GBLUP (MTi-GBLUP) models. In fivefold cross-validation, prediction accuracies ranged from 0.46 (PBN) to 0.49 (MTr-GBLUP) for DBY and from 0.47 (DBN, DAP120) to 0.75 (MTi-GBLUP, DAP60) for PH. Forward-chaining cross-validation further improved prediction accuracies of the DBN, MTi-GBLUP and MTr-GBLUP models for PH (training slice: 30-45 DAP) by 36.4–52.4% relative to the BN and PBN models. Coincidence indices (target: biomass, secondary: PH) and a coincidence index based on lines (PH time series) showed that the ranking of lines by PH changed minimally after 45 DAP. These results suggest a two-level indirect selection method for PH at harvest (first-level target trait) and DBY (second-level target trait) could be conducted earlier in the season based on ranking of lines by PH at 45 DAP (secondary trait). With the advance of high-throughput phenotyping technologies, our proposed two-level indirect selection framework could be valuable for enhancing genetic gain per unit of time when selecting on developmental traits.
El lenguaje de los otros, escenario de alteridades: Aportes a la aproximación teórica entre antropología y literatura
Authors: Perea Fabián 
Published: December 2019

El lenguaje, en su multiplicidad de acción como mecanismo de reconfiguración simbólica, se presenta como un elemento constante en las relaciones sociales. En este sentido la antropología se ha preguntado no sólo por la utilidad del lenguaje en estas relaciones, sino por la forma en la cual este se utiliza dentro de los análisis antropológicos y sus implicaciones metodológicas. La literatura, por su parte, se muestra como un espacio en el que el uso del lenguaje responde principalmente a un ejercicio descriptivo, que trasmuta en la articulación de distintos conceptos simbólicos para la creación de una realidad en la que el autor es el artífice, lo cual crea relaciones entre la realidad simbólica del autor literario y los conceptos abstraídos que representan la organización simbólica de sociedades específicas. Este artículo de revisión busca explorar, a través del uso de las crónicas antropológicas y de textos literarios de ficción, las relaciones entre la antropología y la literatura desde la perspectiva del lenguaje como elemento de creación de alteridad, para proponer aproximaciones teóricas que cuestionen la relación entre el autor y el sujeto observado que, en consecuencia, se presenten como posibilidades de posturas metodológicas en las cuales se haga uso del lenguaje como herramienta analítica.
La novela policiaca de quiosco como narrativa de terror: Villa del Mar y El caserón del órgano de Josefina de la Torre
Authors: García-Aguilar Alberto 
Published: December 2019

Este artículo analiza dos novelas de quiosco publicadas en la década de 1940 por la escritora española Josefina de la Torre: Villa del Mar (1941) y El caserón del órgano (1944). Se estudia cómo reproduce en ellas varios de los rasgos más frecuentes en los subgéneros policiaco y de terror, como el detective como un héroe de aventuras, la (falsa) casa encantada y el asesino increíblemente malvado, para ofrecer unas obras destinadas al ocio de los lectores.
Fenología, sincronía floral y éxito reproductivo de Neolloydia conoidea (Cactaceae)
Authors: Arroyo-Pérez Erika , Jiménez-Sierra Cecilia Leonor , Zavala-Hurtado José Alejandro , Flores-Rivas Joel David , Salgado-Ugarte Isaías Hazarmabeth 
Published: December 2019

Antecedentes: Los estudios sobre los patrones de floración, sincronía floral y éxito reproductivo en cactáceas son incipientes y de muchas especies se desconoce prácticamente su biología reproductiva como ocurre con la cactácea globosa Neolloydia conoidea . Preguntas: ¿Cómo es el patrón de floración a nivel poblacional? ¿Cómo es la sincronía floral? y ¿Existe relación entre la sincronía floral y el éxito reproductivo? Especie: Neolloydia conoidea Britton & Rose (Cactaceae) Sitio de estudio y fechas: Municipio de Tolimán en Querétaro, México. Dos años de observaciones (N = 146 individuos en 2015; 142 en 2016) en una población de Neolloydia conoidea . Métodos: Censo de las flores en antesis y análisis de la fenología de floración a través de Estimadores de Densidad por Kernel (EDK) y componentes gaussianos. Determinación de la sincronía floral a través de los índices de Augspurger (SA) y de Marquis (SM) y comparación del éxito reproductivo (fruit set y seed set) por año y por pulsos. Resultados: Neolloydia conoidea presentó un patrón de floración con 5 a 6 pulsos discretos al año. La sincronía por año y por pulsos fue baja y no se correlacionó con el éxito reproductivo. Conclusiones: Neolloydia conoidea presenta un patrón de floración en pulsos con bajos niveles de sincronía. Este es el primer registro de dicha estrategia para una cactácea globosa, aunque un patrón similar ya ha sido reportado para una cactácea columnar. Sugerimos que esto podría representar una estrategia de “bet hedging” en el sitio de estudio.
Impact of Late Pleistocene-Holocene climatic fluctuations on the phylogeographic structure and historical demographics of Zamia prasina (Cycadales: Zamiaceae)
Authors: Montalvo-Fernández Grecia , Sánchez-Teyer Lorenzo Felipe , Carnevali Germán , Vovides Andrew P. , Gaytán-Legaria Ricardo , Ortíz -García Matilde Margarita , Muñoz-López Jaime Alejandro , Martínez Castillo Jaime 
Published: December 2019

Background: Glacial periods during the Pleistocene have been hypothesized to have greatly influenced geographical patterns of genetic structure and demography of many tropical species. The Glacial Refugium Hypothesis proposes that, during cold, dry glacial periods, populations of moisture-affinities tropical species were restricted to sheltered, humid areas and that, during warmer and more humid interglacial periods, these populations expanded. Some mountain regions in the tropics acted as refugia during the cold, dry periods of the Pleistocene for several temperate forest taxa, which recolonized the humid areas farther north during the interglacial periods.
Questions: (1) Did Late Pleistocene-Holocene climate changes affect the historical demophraphy of Zamia prasina ? (2) Does the historical distribution of Zamia prasina agree with the Glacial Refugium Hypothesis?
Study species: Zamia prasina W.Bull. (Zamiaceae), the only cycad native to the Yucatan Peninsula Biotic Province (YPBP).
Methods: Five individuals were collected in 23 populations and characterized using two DNA regions: plastid atpF-atpH , and nuclear ITS2. Genetic diversity, phylogeographic structure, historical demography, and potential distributions were assessed.
Results: Our results showed moderately high genetic diversity and low, but significant, phylogeographic structure. Two genetic groups were identified, one in the eastern part of the Peninsula, the other in the western. The changes in historical demography suggest that Z. prasina experienced a population expansion following the warm conditions of the Holocene.
Conclusions: The population dynamics of Zamia prasina are in accordance with the Glacial Refugium Hypothesis.
Seed bank formation and removal of Pinus hartwegii (Pinaceae) seeds along an altitudinal gradient in the Cofre de Perote National Park, Veracruz, Mexico
Authors: Tejeda Landero Victor Manuel , Sánchez-Velásquez Lázaro Rafael , Viveros-Viveros Héctor , Aparicio-Rentería Armando , Flores-Peredo Rafael 
Published: December 2019

Background: Seed banks, an important element in the natural regeneration of plant communities, are regulated mostly by granivores along an altitudinal gradient. Question/Hypothesis: Pinus hartwegii forms transient and probably persistent seed banks along an altitudinal gradient. Seed removal will vary according to the removing agents, the altitude and the season. Species under study/Data description/Mathematical model: The formation of seed banks and the removal of Pinus hartwegii (Pinaceae) seeds along an altitudinal gradient were evaluated in different seasons using a linear model with two factorial variance analyses. Site and years of study: The study was conducted at the Cofre de Perote National Park, Veracruz, Mexico, over an altitudinal gradient (at 3,400, 3,600, 3,800 and 4,000 m a.s.l.) in July-September 2015 (rainy season), and January-March 2016 (dry season). Methods: In order to understand seed bank formation and identify the removal agents along an altitudinal gradient, two experiments were conducted with seeds from 10 trees at each altitudinal tier. Results: The results of the first experiment, after one year, demonstrated the formation of transient and probably persistent seed banks along an altitudinal gradient ( P < 0.0001). The results of the second experiment showed significant variations in seed removal according to the removal agents and the seasons ( P < 0.0001). Conclusions: Pinus hartwegii forms transient and probably persistent seed banks along an altitudinal gradient. Seed removal varies according to altitude and season.
Orquídeas silvestres comercializadas en un mercado tradicional de Chiapas, México
Authors: Jiménez-López Derio Antonio , Pérez-García Eduardo Alberto , Martínez-Meléndez Nayely , Solano Rodolfo 
Published: December 2019

Antecedentes: La comercialización de orquídeas es una práctica común en los mercados mexicanos, especialmente en regiones de alta biodiversidad.
Preguntas y/o hipótesis: ¿Cuántas especies de orquídeas se vendieron en el mercado de Las Margaritas? ¿De dónde se extrajeron? ¿Su disponibilidad (riqueza) mostró una variación temporal a lo largo de un año? ¿Cuál fue la relación entre la vistosidad de las flores (tamaño) y su precio de venta?
Especies en estudio: Familia Orchidaceae.
Sitio de estudio y fechas: Mercado de Las Margaritas, Chiapas, 2014.
Métodos: Entrevistamos a 15 vendedores del mercado (12 mujeres y tres hombres). Determinamos todas las especies comercializadas, su lugar de extracción, y analizamos la relación entre la vistosidad de cada flor y su precio de venta, mediante un análisis de correlación.
Resultados: Se registraron 60 orquídeas en venta. Cuatro de éstas, estaban en alguna categoría de riesgo (NOM-059- SEMARNAT-2010): Lycaste skinneri , Laelia superbiens , Cuitlauzina pulchella and Oncidium leucochilum . El período de mayor venta fue de diciembre a enero, mientras que el más bajo fue septiembre y octubre. La mayoría de las orquídeas fueron extraídas de la Región Terrestre Prioritaria El Momón-Montebello. La vistosidad se relacionó con precios de venta más altos ( r = 0,67, p < 0,01).
Conclusiones: Se observó una relación significativa entre la vistosidad de la flor y el precio de venta. La comercialización de orquídeas se realizó durante todo el año; sin embargo, mostró dos picos altos (entre diciembre - enero y mayo -junio). Por lo tanto, es necesario organizar talleres con los vendedores para discutir la posibilidad de continuar esta actividad bajo un marco legal regulado.