bluuebunny/crossref_metadata_2025_split huggingface dataset:
CT-Based Radiomics to Differentiate Pelvic Rhabdomyosarcoma From Yolk Sac Tumors in Children
Authors: Chen Xin , Huang Yan , He Ling , Zhang Ting , Zhang Li , Ding Hao 
Published: November 2020

BackgroundThe purpose of this study was to investigate the role of CT radiomics features combined with a support vector machine (SVM) model in potentially differentiating pelvic rhabdomyosarcoma (RMS) from yolk sac tumors (YSTs) in children.MethodsA total of 94 patients with RMS (n = 49) and YSTs (n = 45) were enrolled. Non-enhanced phase (NP), arterial phase (AP), and venous phase (VP) images were retrieved for analysis. The volumes of interest (VOIs) were constructed by segmenting tumor regions on CT images to extract radiomics features. Datasets were randomly divided into two sets including a training set and a test set. In the training set, the least absolute shrinkage and selection operator (LASSO) algorithm was used to screen out the optimal radiomics features that could distinguish RMS from YSTs, and the features were combined with the SVM algorithm to build the classifier model. In the testing set, the areas under the receiver operating characteristic (ROC) curves (AUCs), accuracy, specificity, and sensitivity of the model were calculated to evaluate its diagnostic performance. The clinical factors (including age, sex, tumor site, tumor volume, AFP level) were collected.ResultsIn total, 1,321 features were extracted from the NP, AP, and VP images. The LASSO regression algorithm was used to screen out 23, 26, and 17 related features, respectively. Subsequently, to prevent model overfitting, the 10 features with optimal correlation coefficients were retained. The SVM classifier achieved good diagnostic performance. The AUCs of the NP, AP, and VP radiomics models were 0.937 (95% CI: 0.862, 0.978), 0.973 (95% CI: 0.913, 0.996), and 0.855 (95% CI: 0.762, 0.922) in the training set, respectively, which were confirmed in the test set by AUCs of 0.700 (95% CI: 0.328, 0.940), 0.800 (95% CI: 0.422, 0.979), and 0.750 (95% CI: 0.373, 0.962), respectively. The difference in sex, tumor volume, and AFP level were statistically significant (P &lt; 0.05).ConclusionsThe CT-based radiomics model can be used to effectively distinguish RMS and YST, and combined with clinical features, which can improve diagnostic accuracy and increase the confidence of radiologists in the diagnosis of pelvic solid tumors in children.
Pinocembrin Decreases Ventricular Fibrillation Susceptibility in a Rat Model of Depression
Authors: Ye Tianxin , Zhang Cui , Wu Gang , Wan Weiguo , Guo Yan , Fo Yuhong , Chen Xiuhuan , Liu Xin , Ran Qian , Liang Jinjun , Shi Shaobo , Yang Bo 
Published: November 2020

Background: Depression is associated with the increased risk of mortality and morbidity and is an independent risk factor for many cardiovascular diseases. Depression may promote cardiac arrhythmias, but little is known about the mechanisms. Pinocembrin mitigated depressive-like behaviors and exhibited cardioprotective effects in several models; however, whether pinocembrin benefits ventricular arrhythmias in depression models has not been elucidated. Thus, this study was to evaluate the effects of pinocembrin on ventricular fibrillation susceptibility in rat models of depression.Methods: Male Sprague-Dawley rats were randomly assigned into control, control + pinocembrin, MDD (major depressive disorder), and MDP (MDD + pinocembrin) groups, respectively. Depressive-like behaviors, ventricular electrophysiological parameters, electrocardiogram parameters, heart rate variability, ventricular histology, serum norepinephrine, tumor necrosis factor-α, and interleukin-1β were detected. Protein levels in left ventricle were measured by Western blot assays.Results: Compared with the MDD group, pinocembrin significantly mitigated depressive-like behaviors, prolonged ventricular effective refractory period, action potential duration, QT, and corrected QT (QTc) interval, improved heart rate variability, decreased Tpeak–Tend interval, ventricular fibrillation inducibility rate, ventricular fibrosis, ventricular positive nerve densities, and protein expression of tyrosine hydroxylase and growth associated protein-43, reduced serum norepinephrine, tumor necrosis factor-α, interleukin-1β concentrations, and the expression levels of p-IκBα and p-p65, and increased the protein expression of Cx43, Cav1.2, and Kv.4.2 in the MDP group.Conclusion: Pinocembrin attenuates ventricular electrical remodeling, autonomic remodeling, and ion-channel remodeling, lowers ventricular fibrosis, and suppresses depression-induced inflammatory responses, providing new insights in pinocembrin and ventricular arrhythmias in depressed patients.
Variants of the Aggression-Related RBFOX1 Gene in a Population Representative Birth Cohort Study: Aggressiveness, Personality, and Alcohol Use Disorder
Authors: Vaht Mariliis , Laas Kariina , Fernàndez-Castillo Noèlia , Kurrikoff Triin , Kanarik Margus , Faraone Stephen V. , Tooding Liina-Mai , Veidebaum Toomas , Franke Barbara , Reif Andreas , Cormand Bru , Harro Jaanus 
Published: November 2020

Background: Recently, RBFOX1, a gene encoding an RNA binding protein, has consistently been associated with aggressive and antisocial behavior. Several loci in the gene have been nominally associated with aggression in genome-wide association studies, the risk alleles being more frequent in the general population. We have hence examined the association of four RBFOX1 single nucleotide polymorphisms, previously found related to aggressive traits, with aggressiveness, personality, and alcohol use disorder in birth cohort representative samples.Methods: We used both birth cohorts of the Estonian Children Personality Behavior and Health Study (ECPBHS; original n = 1,238). Aggressiveness was assessed using the Buss–Perry Aggression Questionnaire and the Lifetime History of Aggressiveness structured interview at age 25 (younger cohort) or 33 (older cohort). Big Five personality at age 25 was measured with self-reports and the lifetime occurrence of alcohol use disorder assessed with the MINI interview. RBFOX1 polymorphisms rs809682, rs8062784, rs12921846, and rs6500744 were genotyped in all participants. Given the restricted size of the sample, correction for multiple comparisons was not applied.Results: Aggressiveness was not significantly associated with the RBFOX1 genotype. RBFOX1 rs8062784 was associated with neuroticism and rs809682 with extraversion. Two out of four analyzed RBFOX1 variants, rs8062784 and rs12921846, were associated with the occurrence of alcohol use disorder.Conclusions: In the birth cohort representative sample of the ECPBHS, no association of RBFOX1 with aggressiveness was found, but RBFOX1 variants affected basic personality traits and the prevalence of alcohol use disorder. Future studies on RBFOX1 should consider the moderating role of personality and alcohol use patterns in aggressiveness.
Embracing the Social Nature of Recovery: A Qualitative Study on the Resource Group Method for People With Severe Mental Illness
Authors: Tjaden Cathelijn D. , Boumans Jenny , Mulder Cornelis L. , Kroon Hans 
Published: November 2020

Objective: The resource group method for people with severe mental illness might provide a useful framework to facilitate patient's empowerment and systematically engage significant others. However, no research has explored the perspectives and experiences of patients and their significant others. This is crucial for better adjustment to the needs of the people using the method. The aim of this study was to develop a useful framework for a deeper understanding of the resource group method and its outcomes.Method: The study used a longitudinal, qualitative multiple case-study design based on grounded theory methodology. During a period of 2 years, the developments and processes in eight resource groups were explored by conducting a total of 74 interviews (e.g., with patients, significant others, and mental health professionals) and 26 observations of resource group meetings.Results: Analysis showed that a well-functioning resource group set the stage for five processes to unfold: (i) experience of support; (ii) acknowledgment of significant others; (iii) activation; (iv) openness; and (v) integration. These processes facilitated recovery both in terms of an arousing curiosity within the patient as well as increasing reciprocity and equality in their social relations. In addition, the method emphasized the uniqueness of each recovery journey, thereby providing a framework to shape recovery-oriented care. The analysis also revealed three hindering factors: (i) embedding and implementation issues; (ii) predominant network; and (iii) tensions inherent in the resource group setting.Conclusion: Working according to the resource group method involves that the person's recovery work becomes a social process that takes place in relation to the social environment and everyday life in which it is important to acknowledge and integrate the needs of significant others in treatment and care. This study provides a first step toward a multidimensional comprehension of the resource group method, the working mechanisms and its influence on recovery for people with severe mental illness.
Early Intervention Services for First Episode of Psychosis in South London and the Maudsley (SLaM): 20 Years of Care and Research for Young People
Authors: Fusar-Poli Paolo , Lai Serena , Di Forti Marta , Iacoponi Eduardo , Thornicroft Graham , McGuire Philip , Jauhar Sameer 
Published: November 2020

Introduction: Early Intervention for a first episode of Psychosis (EI) is essential to improve outcomes. There is limited research describing real-world implementation of EI services.Method: Analysis of service characteristics, outcomes (described through a retrospective 2007–2017 Electronic Health Record (EHR) cohort study) and clinical research relating to the first 20 years of implementation of EI services in South London and Maudsley (SLaM) Trust.Results: SLaM EI are standalone services serving 443,050 young individuals in South-London, where (2017) incidence of psychosis (58.3–71.9 cases per 100,000 person-years) is greater than the national average. From 2007–2017 (when the EHR was established), 1,200 individuals (62.67% male, mean age 24.38 years, 88.17% single; two-thirds of non-white ethnicity) received NICE-compliant EI care. Pathways to EI services came mainly (75.26%) through inpatient (39.83%) or community (19.33%) mental health services or Accident and Emergency departments (A&amp;E) (16%). At 6 year follow-up 34.92% of patients were still being prescribed antipsychotics. The 3 month and 6 year cumulative proportions of those receiving clozapine were 0.75 and 7.33%; those compulsorily admitted to psychiatric hospitals 26.92 and 57.25%; those admitted to physical health hospitals 6.83 and 31.17%, respectively. Average 3 months and 6 year days spent in hospital were 0.82 and 1.85, respectively; mean 6 year attendance at A&amp;E was 3.01. SLaM EI clinical research attracted £58 million grant income and numerous high-impact scientific publications.Conclusions: SLaM EI services represent one of the largest, most established services of its kind, and are a leading model for development of similar services in the UK and worldwide.
Characterization of Soft S-Open Sets in Bi-Soft Topological Structure Concerning Crisp Points
Authors: Mehmood Arif , Al-Shomrani Mohammed M. , Zaighum Muhammad Asad , Abdullah Saleem 
Published: November 2020

In this article, a soft s-open set in soft bitopological structures is introduced. With the help of this newly defined soft s-open set, soft separation axioms are regenerated in soft bitopological structures with respect to crisp points. Soft continuity at some certain points, soft bases, soft subbase, soft homeomorphism, soft first-countable and soft second-countable, soft connected, soft disconnected and soft locally connected spaces are defined with respect to crisp points under s-open sets in soft bitopological spaces. The product of two soft axioms with respect crisp points with almost all possibilities in soft bitopological spaces relative to semiopen sets are introduced. In addition to this, soft (countability, base, subbase, finite intersection property, continuity) are addressed with respect to semiopen sets in soft bitopological spaces. Product of soft first and second coordinate spaces are addressed with respect to semiopen sets in soft bitopological spaces. The characterization of soft separation axioms with soft connectedness is addressed with respect to semiopen sets in soft bitopological spaces. In addition to this, the product of two soft topological spaces is ( space if each coordinate space is soft space, product of two sot topological spaces is (S regular and C regular) space if each coordinate space is (S regular and C regular), the product of two soft topological spaces is connected if each coordinate space is soft connected and the product of two soft topological spaces is (first-countable, second-countable) if each coordinate space is (first countable, second-countable).
Concordance in the recording of stroke across UK primary and secondary care datasets: a population-based cohort study
Authors: Morgan Ann , Sinnott Sarah-Jo , Smeeth Liam , Minassian Caroline , Quint Jennifer 
Published: November 2020

BackgroundPrevious work has demonstrated that the recording of acute health outcomes, such as myocardial infarction (MI), may be suboptimal in primary healthcare databases.AimTo assess the completeness and accuracy of the recording of stroke in UK primary care.Design & settingA population-based longitudinal cohort study.MethodCases of stroke were identified separately in Clinical Practice Research Datalink (CPRD) primary care records and linked Hospital Episode Statistics (HES). The recording of events in the same patient across the two datasets was compared. The reliability of strategies to identify fatal strokes in primary care and hospital records was also assessed.ResultsOf the 75 674 stroke events that were identified in either CPRD or HES data during the period of the study, 54 929 (72.6%) were recorded in CPRD and 51 013 (67.4%) were recorded in HES. Two-fifths (n = 30 268) of all recorded strokes were found in both datasets (allowing for a time window of 120 days). Among these 'matched' strokes the subtype was recorded accurately in approximately 75% of CPRD records (compared with coding in HES); however, 43.5% of ischaemic strokes in HES were coded as 'non-specific' strokes in CPRD data. Furthermore, 48.2% had same-day recordings, and 56.2% were date-matched within ±1 day.ConclusionThe completeness and accuracy of stroke recording is improved by the use of linked hospital and primary care records. For studies that have a time-sensitive research question, the use of linked, as opposed to stand-alone, CPRD data is strongly recommended.
Penggunaan SQ3R dalam Meningkatkan Kemampuan Membaca Cepat
Authors: Purwaningsih Sri 
Published: November 2020

Belajar adalah proses yang aktif ketika siswa harus terlibat langsung dalam berbagai kegiatan pembelajaran sebagai respons terhadap stimulus guru. Stimulus yang diberikan guru tidak akan berarti tanpa adanya perhatian dan motivasi siswa. Menumbuhkan motivasi siswa dapat dilakukan dengan menerapkan metode SQ3R. Oleh Karena itu, artikel ini akan memaparkan penggunaan SQ3R dalam meningkatkan pembelajaran membaca cepat. Subjek dalam penelitian adalah siswa kelas IX B. Teknik pengumpulan data menggunakan tes dan lembar observasi, sedangkan analisis data menggunakan deskriptif kualitatif dan kuantitatif. Hasil penelitian menunjukkan rata-rata kecepatan baca siswa pada siklus I yaitu 140 kpm dan rata-rata persentase pemahaman isi bacaan 54%, sedangkan pada siklus II, rata-rata kecepatan baca pada siklus II yaitu 175 kpm, rata-rata persentase pamahaman isi bacaan yaitu 90%. Berdasarkan itu, dapat disimpulkan bahwa SQ3R mampu meningkatkan kemampuan membaca siswa.Kata kunci: SQ3R, KEM, membaca cepat Learning is an active process when students must be directly involved in various learning activities in response to teacher stimulus. The stimulus given by the teacher will not be meaningful without the attention and motivation of students. Growing student motivation can be done by applying the SQ3R method. Therefore, this article will explain the use of SQ3R in improving speed reading learning. Subjects in the study were students of class IX B. Data collection techniques used tests and observation sheets, while data analysis used descriptive qualitative and quantitative. The results showed the average reading speed of students in the first cycle was 140 kpm and the average percentage of reading content comprehension was 54%, whereas in the second cycle, the average reading speed in the second cycle was 175 kpm, the average percentage of reading content reading i.e. 90%. Based on that, it can be concluded that SQ3R can improve students' reading abilities.Keywords: SQ3R, KEM, speed reading
Penggunaan Huruf Kapital dan Tanda Baca dalam Teks Biografi
Authors: Komalasari Fatia 
Published: November 2020

Artikel ini membahas penggunaan huruf kapital dan tanda baca dalam tulisan peserta didik pada teks autobiografi. Metode yang digunakan dalam penelitian ialah metode deskriptif kualitatif dengan sumber data primer. Berdasarkan hasil analisis, masih banyak peserta didik yang melakukan kesalahan dalam penggunaan huruf kapital dan tanda baca. Kesalahan terbesar dalam penggunaan huruf kapital yaitu sebagai huruf pertama awal kalimat dengan persentase 56%. Sedangkan kesalahan terbesar dari penggunaan tanda baca yaitu dalam penggunaan tanda koma dengan persentase 50%. Penyebab utama timbulnya kesalahan tersebut karena keterbiasaan peserta didik dan kurangnya pengetahuan mengenai ejaan yang disempurnakan khusunya pada huruf kapital dan tanda baca.Kata kunci: huruf kapital, tanda baca, teks autobigrafiThis article discusses the use of capital letters and punctuation in students' writing in autobiographical texts. The method used in this research is a qualitative descriptive method with primary data sources. Based on the results of the analysis, there are still many students who make mistakes in the use of capital letters and punctuation. The biggest mistake in using capital letters is as the first letter of the beginning of the sentence with a percentage of 56%. While the biggest mistake of using punctuation is in the use of commas with a percentage of 50%. The main cause of these errors is due to students' habits and lack of knowledge about enhanced spelling especially in capital letters and punctuation.Keywords: capital letters, punctuation, autobigraphic text
ANALISIS HUKUM PENGEMBANGAN POTENSI WISATA PANTAI JAYANTI CIANJUR TERHADAP KEWENANGAN PEMERINTAH KABUPATEN CIANJUR
Authors: Hasanudin Asep 
Published: November 2020

This study aims to describe the form of policies, problems encountered, and efforts that must be developed by the Regional Government of Cianjur Regency in the Development of Jayanti Tourism Potential as a tourism asset. The method of approach used in this research is Normative Jurisprudence, namely by studying and reviewing the principles of law, especially positive legal principles derived from existing literature from legislation and provisions, especially relating to tourism. Tourism is a temporary and short-term transformation of people towards destinations outside the place where they live and work. With the Law of the Republic of Indonesia Number 10 of 2009 Concerning Tourism and bearing in mind that Tourism is an inseparable part of national development, the tourism potential of the Jayanti coast really needs to be given more attention by local governments to be developed, in order to improve the economy of Cianjur regency to be more prosperous.Keywords: Development; Tourism; Jayanti Tourism Potential; Tourism Potential.
PERAN PEMERINTAH DALAM MEMBERIKAN DANA INSENTIF GUNA MENDUKUNG PEMBANGUNAN EKONOMI KREATIF DAERAH
Authors: Kamilah Anita 
Published: November 2020

With the enactment of the ASEAN Free Trade Area (AFTA) and the ASEAN Economic Community (AEC) in early 2016, global markets between ASEAN regions are increasingly open and competition between countries is very tight in marketing their creative economy products or services. These conditions, spurred the Indonesian people including the Cianjur Regency Government to increase and take advantage of business opportunities through the development of a relative economy in order to increase regional economy. But the development of the creative economy is hampered in getting funding support. In connection with this, what is the background of the Cianjur regency government to develop creative economic policies and how government support in providing access to capital in developing the regional creative economy. In order to examine this problem, the method used is juridical normative approach, by studying the principles of law, especially positive legal rules that have a relationship with the problem that is the object of research. Keywords: Creative Economy; Era of Globalization; Incentive Funds.
OPTIMALISASI PERAN PEMERINTAH DAERAH DALAM PERLINDUNGAN HUKUM TERHADAP BERAS BERDASARKAN KONSEP KEDAULATAN PANGAN DI INDONESIA
Authors: Aridhayandi M. Rendi 
Published: November 2020

As a staple food in Indonesia, the availability of rice are needed to continue until whenever. Because agriculture is still the source of livelihood of the majority of the workforce in Indonesia. Hence the presence of the government is necessary, governments can differentiate into central government and local governments. In UUD 1945 Pasal 18A ayat (1) mentions the relationship of authority between the central government and provincial government, counties, and cities, or between provinces and districts and cities, regulated by law with due regard to the specificity and diversity of the area. Regional autonomy is one manifestation of freedom for the regions to be involved in designing the activity of politics and government at the local level in order to strengthen the power of national government. Thus the role of local government is very important to the affairs of the availability of rice in the presence of local autonomy. The local government and regional autonomy can be free to design a territory in support of the central government towards food security.Undang-Undang No. 18 tahun 2012 tentang Pangan mentions the issue of food intended to achieve three things at once, namely food sovereignty, food self-sufficiency and food security. President Jokowi that: "Food security is distinct from food sovereignty. Food security is simply the availability of foodstuffs (logistics) in the warehouse and on the market irrespective of origin whether imported or locally produced. Food sovereignty means that we manufacture and market our own groceries, while surplus production is exported ". Here we can see that food sovereignty is significantly deeper than food security. thus, the optimization of local governments in order to achieve food sovereignty can be: 1. the agrarian reform (land protection by performing a spatial planning regulations); 2. the legal protection to farmers (by making regulations that aim the welfare of farmers); 3. the availability of seeds, fertilizers and tools supporting production; 4. Registering brands and geographical indications of agricultural products to the Directorate General of Intellectual Property Ministry of law and Human Rights Republic of Indonesia; 5. setting the price, product quality and market share of an agricultural product. Keywords: Food Security; Food Sovereignty; Rice; Regional Government.