bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potentiality of forkhead box Q1 as a biomarker for monitoring tumor features and predicting prognosis in non‐small cell lung cancer
Authors: Li Lan , Xu Bin , Zhang Huibo , Wu Jie , Song Qibin , Yu Jinming 
Published: November 2019

AbstractBackgroundThis study aimed to explore the correlation of forkhead box Q1 (FOXQ1) with clinicopathological features and survival profiles in patients with non‐small cell lung cancer (NSCLC).MethodsA total of 238 NSCLC patients with TNM stage I‐III who underwent surgical resection were reviewed, and the expression of FOXQ1 in tumor and paired adjacent tissue was detected using immunohistochemistry assays. The clinical data and survival data of patients with NSCLC were retrieved and calculated.ResultsFOXQ1 expression was increased in tumor tissue (61.3% high expression and 38.7% low expression) compared with paired adjacent tissue (37.8% high expression and 62.2% low expression) (P < .001). In addition, high FOXQ1 expression was associated with larger tumor size (P = .042), lymph node metastasis (P = .040), and advanced TNM stage (P = .002). Disease‐free survival (DFS) (P = .016) and overall survival (OS) (P = .008) were both reduced in patients with high FOXQ1 expression compared with patients with low FOXQ1 expression. Additionally, high FOXQ1 expression (P = .043), poor pathological differentiation (P = .003), and lymph node metastasis (P < .001) were independent risk factors for DFS, and high FOXQ1 expression (P = .021), tumor size (>5 cm) (P = .014), and lymph node metastasis (P < .001) were independent risk factors for OS.ConclusionHigh FOXQ1 expression is associated with advanced tumor features as well as undesirable survival profiles in patients with NSCLC, implying the potential prognostic value of FOXQ1 for NSCLC.
Circ‐MTO1 correlates with favorable prognosis and inhibits cell proliferation, invasion as well as miR‐17‐5p expression in prostate cancer
Authors: Hu Yijia , Guo Bin 
Published: November 2019

AbstractBackgroundThis study aimed to investigate circular RNA‐mitochondrial tRNA translation optimization 1 (circ‐MTO1) expression in tumor tissue and its correlation with clinical characteristics and survival profiles, as well as its effect on cancer cell functions in prostate cancer.MethodsA total of 298 primary prostate cancer patients were included. Reverse transcription‐quantitative polymerase chain reaction was conducted to evaluate circ‐MTO1 expression in tumor tissue and paired adjacent tissue. Disease‐free survival (DFS) and overall survival (OS) were recorded. In in vitro experiment, prostate cancer cells were transfected with circ‐MTO1 over‐expression and negative‐control over‐expression plasmids. Then cell proliferation, cell invasion and miR‐630 as well as miR‐17‐5p expressions in prostate cancer cells were detected.ResultsCircular RNA‐mitochondrial tRNA translation optimization 1 expression was downregulated in tumor tissue compared with paired adjacent tissue (P < .001) in patients with prostate cancer. Circ‐MTO1 high expression in tumor tissue was correlated with decreased pathological T stage (P = .001) as well as lower pathological N stage (P = .020). As for survival profiles, the DFS (P = .006) and OS (P = .018) were both longer in patients who had circ‐MTO1 high expression compared with patients who had circ‐MTO1 low expression. In addition, circ‐MTO1 high expression independently predicted favorable DFS and OS. Besides, further in vitro experiments illustrated that circ‐MTO1 inhibited proliferation (P < .05) and invasion (P < .05) as well as downregulated miR‐17‐5p expression in prostate cancer cells (P < .05).ConclusionCirc‐MTO1 correlates with decreased pathological T/N stage and favorable survival profiles, and it also inhibits cell proliferation, invasion as well as miR‐17‐5p expression in prostate cancer.
Youth's school experience: Testing the role of symptoms of anxiety and co‐occurring symptoms of depression
Authors: Tan Tony Xing , Teng Yuejia , Velasco Juliana C. 
Published: November 2019

AbstractAlthough symptoms of anxiety often coexist with symptoms of depression, little is known on how such coexistence affects youth's school experiences.Objectives: We tested how the two types of behaviors, when coexisting, were associated with youth's negative attitude toward teachers, school, and poor peer relations.Method: Data were collected from 203 ethnically and socioeconomically diverse youth (male: 24.6%; mean = 15.8 years, standard deviation = 2.4) with the 3rd edition of the Behavioral Assessment for Children: Self‐Report of Personality.Results: Scores for symptoms of depression alone explained negative attitude toward teachers (β = .28; R2 = 17.88%), negative attitude toward school (β = .27; R2 = 14.74%), and poor peer relations (β = .42; R2 = 44.60%) as effectively as scores for both types of behaviors did.Conclusion: The coexistence of symptoms of anxiety and depression did not appear to impair youth's attitude toward teachers, school and peer relations more than symptoms of depression did alone.
Foliar epidermal anatomy of some selected wild edible fruits of Pakistan using light microscopy and scanning electron microscopy
Authors: Sadia Haleema , Zafar Muhammad , Ahmad Mushtaq , Lubna  , Khan Muhammad P. Z. , Yaseen Ghulam , Ali Muhammad I. , Sultana Shazia , Kilic Omer , Şahan Zeynep , Alam Naveed , Abbas Qamar , Ghani Abdul , Naz Saeeda 
Published: November 2019

AbstractThe present study is focused on the detailed foliar epidermal anatomy of some selected wild edible fruits (WEFs) from Pakistan using light microscopy (LM) and scanning electron microscopy (SEM). The studied species are Ficus racemosa L., Solanum nigrum L., Capparis spinosa L., Physalis divaricata D.Don, Rosa moschata Herrm. and Ribes orientale Desf. collected from various localities of Pakistan. The objective of the present study is to investigate qualitative and quantitative anatomical characters for the identification and differentiation of collected wild edible fruits. The characters studied are shape and size of epidermal cells, anticlinal wall pattern, trichome type and shape, average number of stomata, length and width of stomata and pore. The detailed microscopic investigation and variations in the characters recorded have a key role in the determination and authentication of wild edible fruits. This study possesses great potential for plant taxonomists to further evaluate the species at molecular and genetic levels.
Comparison of biological properties of [177Lu]Lu‐ProBOMB1 and [177Lu]Lu‐NeoBOMB1 for GRPR targeting
Authors: Rousseau Etienne , Lau Joseph , Zhang Zhengxing , Zhang Chengcheng , Kwon Daniel , Uribe Carlos F. , Kuo Hsiou‐Ting , Zeisler Jutta , Bratanovic Ivica , Lin Kuo‐Shyan , Bénard François 
Published: November 2019

AbstractThe gastrin‐releasing peptide receptor (GRPR) is overexpressed in prostate cancer and other solid malignancies. Following up on our work on [68Ga]Ga‐ProBOMB1 that had better imaging characteristics than [68Ga]Ga‐NeoBOMB1, we investigated the effects of substituting 68Ga for 177Lu to determine if the resulting radiopharmaceuticals could be used with a therapeutic aim. We radiolabeled the bombesin antagonist ProBOMB1 (DOTA‐pABzA‐DIG‐D‐Phe‐Gln‐Trp‐Ala‐Val‐Gly‐His‐Leu‐ψ‐Pro‐NH2) with lutetium‐177 and compared it with [177Lu]Lu‐NeoBOMB1 (obtained in 54.2 ± 16.5% isolated radiochemical yield with >96% radiochemical purity and 440.8 ± 165.1 GBq/μmol molar activity) for GRPR targeting. Lu‐NeoBOMB1 had better binding affinity for GRPR than Lu‐ProBOMB1 (Ki values: 2.26 ± 0.24 and 30.2 ± 3.23nM). [177Lu]Lu‐ProBOMB1 was obtained in 53.7 ± 5.4% decay‐corrected radiochemical yield with 444.2 ± 193.2 GBq/μmol molar activity and >95% radiochemical purity. In PC‐3 prostate cancer xenograft mice, tumor uptake of [177Lu]Lu‐ProBOMB1 was 3.38 ± 1.00, 1.32 ± 0.24, and 0.31 ± 0.04%ID/g at 1, 4, and 24 hours pi. However, the uptake in tumor was lower than [177Lu]Lu‐NeoBOMB1 at all time points. [177Lu]Lu‐ProBOMB1 was inferior to [177Lu]Lu‐NeoBOMB1, which had better therapeutic index for the organs receiving the highest doses.
Hyperinsulinaemic hypoglycaemia: A rare association of vanishing white matter disease
Authors: Bursle Carolyn , Yiu Eppie M. , Yeung Alison , Freeman Jeremy L. , Stutterd Chloe , Leventer Richard J. , Vanderver Adeline , Yaplito‐Lee Joy 
Published: November 2019

AbstractWe report two unrelated patients with infantile onset leukoencephalopathy with vanishing white matter (VWM) and hyperinsulinaemic hypoglycaemia. To our knowledge, this association has not been described previously. Both patients had compound heterozygous pathogenic variants in EIF2B4 detected on exome sequencing and absence of other variants which might explain the hyperinsulinism. Hypoglycaemia became apparent at 6 and 8 months, respectively, although in one patient, transient neonatal hypoglycaemia was also documented. One patient responded to diazoxide and the other was managed with continuous nasogastric feeding. We hypothesise that the pathophysiology of hyperinsulinism in VWM may involve dysregulation of transcription of genes related to insulin secretion.
Parametric Hemodynamic 4D Flow MRI Maps for the Characterization of Chronic Thoracic Descending Aortic Dissection
Authors: Jarvis Kelly , Pruijssen Judith T. , Son Andre Y. , Allen Bradley D. , Soulat Gilles , Vali Alireza , Barker Alex J. , Hoel Andrew W. , Eskandari Mark K. , Malaisrie S. Chris , Carr James C. , Collins Jeremy D. , Markl Michael 
Published: November 2019

BackgroundSystematic evaluation of complex flow in the true lumen and false lumen (TL, FL) is needed to better understand which patients with chronic descending aortic dissection (DAD) are predisposed to complications.PurposeTo develop quantitative hemodynamic maps from 4D flow MRI for evaluating TL and FL flow characteristics.Study TypeRetrospective.PopulationIn all, 20 DAD patients (age = 60 ± 11 years; 12 male) (six medically managed type B AD [TBAD], 14 repaired type A AD [rTAAD] now with ascending aortic graft [AAo] or elephant trunk [ET1] repair) and 21 age‐matched controls (age = 59 ± 10 years; 13 male) were included.Field Strength/Sequence1.5T, 3T, 4D flow MRI.Assessment4D flow MRI was acquired in all subjects. Data analysis included 3D segmentation of TL and FL and voxelwise calculation of forward flow, reverse flow, flow stasis, and kinetic energy as quantitative hemodynamics maps.Statistical TestsAnalysis of variance (ANOVA) or Kruskal–Wallis tests were performed for comparing subject groups. Correlation and Bland–Altman analysis was performed for the interobserver study.ResultsPatients with rTAAD presented with elevated TL reverse flow (AAo repair: P = 0.004, ET1: P = 0.018) and increased TL kinetic energy (AAo repair: P = 0.0002, ET1: P = 0.011) compared to controls. In addition, TL kinetic energy was increased vs. patients with TBAD (AAo repair: P = 0.021, ET1: P = 0.048). rTAAD was associated with higher FL kinetic energy and lower FL stasis compared to patients with TBAD (AAo repair: P = 0.002, ET1: P = 0.024 and AAo repair: P = 0.003, ET1: P = 0.048, respectively).Data ConclusionQuantitative maps from 4D flow MRI demonstrated global and regional hemodynamic differences between DAD patients and controls. Patients with rTAAD vs. TBAD had significantly altered regional TL and FL hemodynamics. These findings indicate the potential of 4D flow MRI‐derived hemodynamic maps to help better evaluate patients with DAD.Level of Evidence: 3Technical Efficacy Stage: 1J. Magn. Reson. Imaging 2020;51:1357–1368.
Prognostic significance of premature ventricular complex burden on hospitalized patients with heart failure
Authors: Yamada Shinya , Yoshihisa Akiomi , Sato Takamasa , Kamioka Masashi , Kaneshiro Takashi , Oikawa Masayoshi , Kobayashi Atsushi , Ishida Takafumi , Takeishi Yasuchika 
Published: November 2019

AbstractBackgroundThe clinical significance of premature ventricular complexes (PVCs) in heart failure (HF) remains unclear. We aimed to clarify the associations of PVC burden with re‐hospitalization and cardiac death in HF patients.MethodsWe studied 435 HF patients (271 men, mean age 65 years). All patients were hospitalized for worsening HF. After optimal medications, echocardiography, 24 hours Holter monitoring and cardiopulmonary exercise testing were performed before discharge. The clinical characteristics and outcomes of the HF patients were investigated.ResultsDuring a median follow‐up period of 2.3 years, there were 125 (28.7%) cardiac events (re‐hospitalization due to worsening HF, fatal arrhythmias, or cardiac death). The patients with cardiac events had higher PVC burden compared to those without (median 0.374%/d [interquartile range 0.013‐1.510] vs median 0.026%/d [interquartile range 0.000‐0.534], P < .001). We examined cutoff value of PVC burden for predicting cardiac events. Receiver‐operating characteristic analysis showed PVC burden (>0.145%/d) to be a predictive factor of cardiac events (area under the curve: 0.64). Kaplan‐Meier analysis demonstrated that cardiac events were more frequent in patients with high‐PVC burden (>0.145%/d, n = 194) compared to those with low‐PVC burden (≤0.145%/d, n = 241). Furthermore, the high‐PVC burden patients had left ventricular (LV) and atrial dilatation, reduced LV ejection fraction, and impaired exercise capacity, compared to the low‐PVC burden patients. In Cox proportional hazards analysis, high‐PVC burden was significantly associated with cardiac events with a hazard ratio of 2.028 (95% confidence interval: 1.418‐2.901, P < .001).ConclusionThese results suggest that PVC burden is an important predictor of cardiac events in HF patients.
Hemofilter Obstruction with Intravenous Lipid Administration
Authors: Boullata Joseph I. , Stefankiewicz Patricia M. , Gallagher Patricia , Gutsche Jacob 
Published: November 2019

AbstractA critically ill patient requiring continuous venovenous hemofiltration therapy received parenteral nutrition through the same commonly used intravascular device. The inclusion of injectable lipid emulsion had an adverse effect on hemofilter function. This was successfully managed first by using lipid‐free parenteral nutrition and then by administering the total nutrient admixture via a separate central venous access device.
Impact of Transcervical Ultrasound for the Diagnosis of Pediatric Peritonsillar Abscesses on Emergency Department Performance Measures
Authors: Zhao Xian , Delaney Marc , Breslin Kristen , Chamberlain James M. , Rubio Eva I. , Reilly Brian K. , Cohen Joanna S. 
Published: November 2019

ObjectivesTo evaluate the impact of transcervical ultrasound (US) as the initial imaging study for suspected peritonsillar abscesses (PTAs) on pediatric emergency department (ED) throughput measures.MethodsA retrospective cohort study of patients evaluated for suspected PTAs between January 2009 and April 2017 was conducted. We compared the ED length of stay (LOS) before and after implementation of transcervical US to diagnose a PTA. The balancing measure was the rate of return visits within 2 weeks.ResultsThere were 387 eligible patients over the study period. A total of 101 patients were evaluated for PTAs with computed tomography and 286 with US. The mean LOS was significantly less for patients who had US (347 minutes; 95% confidence interval [CI], 330, 364 minutes) compared to computed tomography (426 minutes; 95% CI, 392, 459 minutes), with an absolute difference of 79 minutes (95% CI, 44, 113 minutes). Patients who were evaluated with US did not have an increased rate of return visits (5.9% versus 8.0%; P = .66).ConclusionsThe introduction of transcervical US was associated with a decrease of greater than 1 hour in the ED LOS for patients with suspected PTAs. Given the better radiation profile of US and no increase in the rate of return visits after its implementation, we propose the adoption of a transcervical US‐first approach for the diagnosis of PTAs in pediatrics.
Narrow band imaging in head and neck unknown primary carcinoma: A systematic review and meta‐analysis
Authors: Di Maio Pasquale , Iocca Oreste , De Virgilio Armando , Giudice Marco , Pellini Raul , D'Ascanio Luca , Golusiński Paweł , Ricci Giampietro , Spriano Giuseppe 
Published: November 2019

ObjectiveTo estimate the diagnostic performance of Narrow Band Imaging (NBI) in patients with cervical metastasis from head and neck squamous cell carcinoma of unknown primary (SCCUP) origin.MethodsPubMed, Embase, and Scopus databases were systematically scrutinized up to July 1, 2019, looking for studies that encompassed the NBI in the SCCUP diagnostic work up. The main inclusion criteria for eligible articles for the meta‐analysis were non‐evidence of primary tumor after physical examination and conventional cross‐section imaging before NBI assessment and the availability of complete data on the diagnostic accuracy of NBI. A set of random‐effects model meta‐analyses was then performed following the Meta‐analysis of Observational Studies in Epidemiology (MOOSE) guidelines.ResultsFive studies, conducted between January 2003 and September 2016, comprising 169 patients imaged with NBI, were included in the meta‐analysis. The pooled sensitivity and specificity of NBI in patients with head and neck SCCUP was 0.83 (99% CI, 0.54–0.95) and 0.88 (99% CI, 0.55–0.97), respectively. The positive and negative likelihood ratios were 6.38 (99% CI, 1.6–25.44) and 0.06 (99% CI, 0.005–0.86). The pooled diagnostic odds ratio (DOR) was 82.15 (99% CI, 7.06–955). The overall detection rate of NBI was 0.35 (99% CI, 0.18–0.53), which allowed localization the primary tumor in 61 out of 169 patients, otherwise not detected by the usual diagnostic work‐up.ConclusionsCurrent available evidence suggests that NBI has a considerable diagnostic accuracy in patients affected by head and neck SCCUP.Laryngoscope, 130:1692–1700, 2020
Peak Sinus Pressures During Sneezing in Healthy Controls and Post–Skull Base Surgery Patients
Authors: Wu Zhenxing , Craig John R. , Maza Guillermo , Li Chengyu , Otto Bradley A. , Farag Alexander A. , Carrau Ricardo L. , Zhao Kai 
Published: November 2019

Objectives/HypothesisPatients are frequently advised to sneeze with an open mouth and avoid nose‐blowing following an endoscopic endonasal approache (EEA) to the skull base, despite a lack of quantitative evidence. This study applies computational fluid dynamics (CFD) to quantify sinus pressures along the skull base during sneezing.Study DesignCase–control series.MethodsComputed tomography or magnetic resonance imaging scans of four post‐EEA patients and four healthy controls were collected and analyzed utilizing CFD techniques. A pressure drop of 6,000 Pa was applied to the nasopharynx based on values in the literature to simulate expiratory nasal airflow during sneezing. Peak pressures along the skull base in frontal, ethmoid, and sphenoid sinuses were collected.ResultsSignificant increases in skull base peak pressure was observed during sneezing, with significant individual variations from 2,185 to 5,685 Pa. Interestingly, healthy controls had significantly higher pressures compared to post‐EEA patients (5179.37 ± 198.42 Pa vs. patients 3,347.82 ± 1,472.20 Pa, P < .05), which could be related to higher anterior nasal resistance in unoperated healthy controls (0.44 ± 0.22 vs. 0.31 ± 0.16 Pa/mL/sec for patients, P = .38). The sinus pressure buildup may be due to airway resistance functioning as a valve preventing air from being released quickly. Supporting this theory, there was a strong correlation (r = 0.82) between peak skull base pressure and the ratio of anterior resistance to total resistance. Within‐subject variation in pressures between different skull base regions was much lower (average = ~5%).ConclusionsThis study provided the first quantitative analysis of air pressure along the skull base during sneezing in post‐EEA patients through CFD, suggesting that pressure buildup may depend on individual anatomy.Level of Evidence3b Laryngoscope, 130:2138–2143, 2020
Response of density stratification, aquatic chemistry, and methylmercury to engineered and hydrologic forcings in an endorheic lake (Great Salt Lake, U.S.A.)
Authors: Yang Shu , Johnson William P. , Black Frank J. , Rowland Ryan , Rumsey Christine , Piskadlo Andrew 
Published: November 2019

AbstractElimination of limited flow through the earthen railroad causeway separating the north and south arms of Great Salt Lake, Utah, U.S.A., in late 2013 destratified this meromictic endorheic lake and effectively eliminated previous elevated methylmercury (40–90 ng L−1) in deep waters. Reestablishment of north–south flow in late 2016 offered the opportunity to understand the drivers of density stratification, which in turn drive geochemical conditions supporting mercury methylation at depth. Both engineered (causeway flow reopening) and hydrologic (snowmelt) forcings were observed to initiate meromixis (stratification). Return to meromixis drove anoxia at depth with increased sulfide and methylmercury concentrations. However, shallow brine oxygen concentrations were lower under destratified relative to meromictic conditions, and brief periods of anoxia and elevated sulfide and methylmercury occurred at depth even under destratified conditions, demonstrating oxygen demand by underlying sediment organic matter. Mercury demethylation in deep waters was observed only under destratified conditions when oxygen reached bottom waters. These findings indicate that the deep brine layer acts as a cap that prevents oxygen from the overlying mixolimnion from coming into contact with sediment organic matter and drives accumulation of methylmercury in deep waters under meromictic (stratified) conditions.
Changes in food characteristics reveal indirect effects of lake browning on zooplankton performance
Authors: Minguez Laetitia , Sperfeld Erik , Berger Stella A. , Nejstgaard Jens C. , Gessner Mark O. 
Published: November 2019

AbstractBrowning caused by colored dissolved organic matter is predicted to have large effects on aquatic ecosystems. However, there is limited experimental evidence about direct and indirect effects of browning on zooplankton in complex field settings. We used a combination of an ecosystem‐scale enclosure experiment and laboratory incubations to test how prolonged browning affects physiological and life‐history traits of the water flea Daphnia longispina, a key species in lake food webs, and whether any such effects are reversible. Daphnids and water were collected from enclosures in a deep clear‐water lake, where the natural plankton community had been exposed for 10 weeks to browning or to control conditions in clear water. Daphnid abundance was much lower in the brown than in the clear enclosure. Surprisingly, however, daphnids continuously kept in brown enclosure water in the laboratory showed increased metabolic performance and survival, and also produced more offspring than daphnids kept in clear enclosure water. This outcome was related to more and higher‐quality seston in brown compared to clear water. Moreover, daphnids transferred from clear to brown water or vice versa adjusted their nucleic acid and protein contents, as indicators of physiological state, to similar levels as individuals previously exposed to the respective recipient environment, indicating immediate and reversible browning effects on metabolic performance. These results demonstrate the importance of conducting experiments in settings that capture both indirect effects (i.e., emerging from species interactions in communities) and direct effects on individuals for assessing impacts of browning and other environmental changes on lakes.