bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nilotinib Effects on Safety, Tolerability, and Biomarkers in Alzheimer's Disease
Authors: Turner Raymond S. , Hebron Michaeline L. , Lawler Abigail , Mundel Elizabeth E. , Yusuf Nadia , Starr J. Nathan , Anjum Muhammad , Pagan Fernando , Torres‐Yaghi Yasar , Shi Wangke , Mulki Sanjana , Ferrante Dalila , Matar Sara , Liu Xiaoguang , Esposito Giuseppe , Berkowitz Frank , Jiang Xiong , Ahn Jaeil , Moussa Charbel 
Published: May 2020

ObjectivePreclinical evidence with nilotinib, a US Food and Drug Administration (FDA)‐approved drug for leukemia, indicates improvement in Alzheimer's disease phenotypes. We investigated whether nilotinib is safe, and detectable in cerebrospinal fluid, and alters biomarkers and clinical decline in Alzheimer's disease.MethodsThis single‐center, phase 2, randomized, double‐blind, placebo‐controlled study investigated the safety, tolerability, and pharmacokinetics of nilotinib, and measured biomarkers in participants with mild to moderate dementia due to Alzheimer's disease. The diagnosis was supported by cerebrospinal fluid or amyloid positron emission tomography biomarkers. Nilotinib 150 mg versus matching placebo was taken orally once daily for 26 weeks followed by nilotinib 300 mg versus placebo for another 26 weeks.ResultsOf the 37 individuals enrolled, 27 were women and the mean (SD) age was 70.7 (6.48) years. Nilotinib was well‐tolerated, although more adverse events, particularly mood swings, were noted with the 300 mg dose. In the nilotinib group, central nervous system (CNS) amyloid burden was significantly reduced in the frontal lobe compared to the placebo group. Cerebrospinal fluid Aβ40 was reduced at 6 months and Aβ42 was reduced at 12 months in the nilotinib group compared to the placebo. Hippocampal volume loss was attenuated (−27%) at 12 months and phospho‐tau‐181 was reduced at 6 months and 12 months in the nilotinib group.InterpretationNilotinib is safe and achieves pharmacologically relevant cerebrospinal fluid concentrations. Biomarkers of disease were altered in response to nilotinib treatment. These data support a larger, longer, multicenter study to determine the safety and efficacy of nilotinib in Alzheimer's disease. ANN NEUROL 2020 ANN NEUROL 2020;88:183–194
Understanding the Role of Parallel Pathways via In‐Situ Switching of Quantum Interference in Molecular Tunneling Junctions
Authors: Soni Saurabh , Ye Gang , Zheng Jueting , Zhang Yanxi , Asyuda Andika , Zharnikov Michael , Hong Wenjing , Chiechi Ryan C. 
Published: May 2020

AbstractThis study describes the modulation of tunneling probabilities in molecular junctions by switching one of two parallel intramolecular pathways. A linearly conjugated molecular wire provides a rigid framework that allows a second, cross‐conjugated pathway to be effectively switched on and off by protonation, affecting the total conductance of the junction. This approach works because a traversing electron interacts with the entire quantum‐mechanical circuit simultaneously; Kirchhoff's rules do not apply. We confirm this concept by comparing the conductances of a series of compounds with single or parallel pathways in large‐area junctions using EGaIn contacts and single‐molecule break junctions using gold contacts. We affect switching selectively in one of two parallel pathways by converting a cross‐conjugated carbonyl carbon into a trivalent carbocation, which replaces destructive quantum interference with a symmetrical resonance, causing an increase in transmission in the bias window.
Relationship between structure and dynamic mechanical properties of thermoplastic polyurethane elastomer containing bi‐soft segment
Authors: Liu Yuntong , Liu Li , Liang Yongri 
Published: May 2020

AbstractIn this work, we investigated the microphase separation, mechanical, and dynamic mechanical properties of thermoplastic polyurethane elastomers (TPUs) with one‐soft segment (polypropylene glycol, PPG, or hydroxyl‐terminated polybutadiene, HTPB) or bi‐soft segment (PPG and HTPB) using FTIR, XRD, SAXS and amplitude modulated‐frequency modulated viscoelastic mode of AFM (AM‐FM mode AFM) methods. The results showed that the microphase separation process of hard and soft segments (HS and SS) in TPU containing PPG and HTPB soft segments (PPG‐HTPB‐PU) was restricted by randomly alternated bi‐soft segments, which results in formation of a low content of irregular‐shaped hard domain (HD). In addition, the microphase separation of PPG‐HTPB‐PU induced a triple‐phased structure of HD, HTPB rich phase and mesophase. The mesophase of PPG‐HTPB‐PU was formed of HS, PPG and HTPB segments which were excluded out of HD and HPTB rich domains during microphase separation process. The damping temperature range (at tan δ greater than 0.3) of PPG‐HTPB‐PU was from −14.6 to 32.1°C (46.5°C) which was more broad than that of TPU containing HTPB soft segment (HTPB‐PU). The broad damping temperature range of PPG‐HTPB‐PU is mainly attributed to the enhanced energy consumption caused by the frictional motions of mixed segments of mesophase.
Ionic liquid assisted fabrication of cellulose‐based conductive films for Li‐ion battery
Authors: Zhou Le , Pan Fengjiao , Zeng Shaojuan , Li Qiongguang , Bai Lu , Liu Yanrong , Nie Yi 
Published: May 2020

AbstractAn imidazolium‐based ionic liquid, 1‐ethyl‐3‐methylimidazolium diethyl phosphate ([Emim]DEP) was used to dispense graphene nanoplates (GN) and multiwalled carbon nanotubes (MWCNTs) as well as dissolve cellulose for fabricating composite conductive films. The effects of GN, MWCNTs, and cellulose mass ratios on the electrical conductivity and morphology of the films were investigated. The interaction between GN, MWCNTs, and cellulose was analyzed by SEM, X‐ray diffraction (XRD), TGA, and Raman spectroscopy. The results indicate that [Emim]DEP plays a vital and irreplaceable role in GN and MWCNTs dispersion, cellulose dissolution, and porous formation during the regeneration and drying processes. MWCNTs linked flaky GN and a hybrid structure was constructed elaborately to form a better conductive path and improve the conductivity as well as increase the film stability. For the XRD result, the carbonized GN‐MWCNTs‐cellulose films exhibited the graphitic peaks, showing that the films still retained the structure of carbon atoms or molecules. Besides, the maximum conductivity of carbonized GN‐MWCNTs‐cellulose (7:3:2) composite film was up to 9,009 S m−1, due to the small carbon clusters formation and the high degree of graphitization. Further, the carbonized films were applied as anodes in Li‐ion battery and showed good electrochemical performance. The best cyclic stability (i.e., discharge/charge capacity) of 438/429 mA h g−1 and coulomb efficiency of 50.2% were obtained. This novel and sustainable design is a promising approach to obtain cellulose‐based conductive films and anodes for Li‐ion battery applications.
Importance of various marine coastal habitats during the life cycle ofSpratelloides delicatulusin Con Dao, the oldest MPA in Vietnam
Authors: Pham Manh Hung , Durand Jean‐Dominique , Le Minh Phong , Vo Bich Thao T. , Hoang Duc Huy , Panfili Jacques 
Published: May 2020

AbstractMarine protected areas (MPAs) are set up to conserve biodiversity, but their design is not always based on strictly scientific considerations. Ideally, an MPA should protect all key habitats necessary for a marine species to complete its life cycle. The identification of these key habitats is complex, especially during the early life of marine fishes.A widely distributed tropical and important low trophic‐level fish species,Spratelloides delicatulus(Clupeidae), was used to evaluate the significance of various coastal habitats for its larvae and juveniles in the Con Dao Archipelago MPA in Vietnam. Early stages (larvae and juveniles) were sampled monthly over one year (June 2016 to May 2017) using light traps in three main habitats (seagrass beds, coral reefs and harbour). The species was identified using morphometry and DNA barcoding. Age and growth variables were estimated using otolith daily growth increments.A total of 3,581 fish were caught. The species was not found in captures between January and February, directly linked to the decrease in seawater temperature and was most abundant from April to June. For a subsample of 248 fish (7–38 mm standard length), ages ranged from 7 to 108 days.Captures and back‐calculated birthdates using otolith daily increments showed thatS. delicatulusspawns during the period of high seawater temperature, from March to October. The species colonizes all three habitats during the early stages (0–26 days old), with growth rate lowest on the seagrass beds. Nevertheless, the species occupies seagrass beds exclusively during the older stages.The conservation of seagrass beds in the Con Dao archipelago is essential for protection of juvenile stages of this species but this habitat is presently not included in the MPA patches. Establishment of a continuum of protected areas linking habitats, rather than the existing patches is needed to conserve the complete life cycle of this species in the Con Dao MPA.
Is the cortical capillary renamed as the transcortical vessel in diaphyseal vascularity?
Authors: Asghar Adil , Kumar Ashutosh , Kant Narayan Ravi , Naaz Shagufta 
Published: May 2020

AbstractA recent article published in Nature Metabolism, “A network of trans‐cortical capillaries as a mainstay for blood circulation in long bones,” explained the long bone vascularity. In the mouse model, the authors demonstrated hundreds of transcortical vessels (TCVs) commencing from the bone marrow and traversing the whole cortical thickness. They realized that TCVs were the same as bleeding vessels of periosteal bed observed in the human tibia and femoral epiphysis during surgery. TCVs expressed arterial or venous markers and were proposed to be the backbone of bone vascularity as 80% of arterial and 59% of venous blood distributed through them. This new evidence challenged the existence of the “cortical capillaries” stated in previous literature. We conducted a review of the existing literature to compare this model with those in earlier research. The bone vascularity model was explained by many researchers who did their work in animal models like pig, dog, rabbit, and mouse. The TCVs were identified in these animal model studies as cortical capillaries or vessels of cortical canals. Studies are scarce, showing the presence of TCVs in humans. The role of TCVs in human cortical vascularity remains ambiguous until the substantial evidence is collected in future studies.
Normal human macula densa morphology and cell turnover: A histological, ultrastructural, and immunohistochemical investigation
Authors: Lorenzi Teresa , Graciotti Laura , Sagrati Andrea , Reguzzoni Marcella , Protasoni Marina , Minardi Daniele , Milanese Giulio , Cremona Ottavio , Fabri Mara , Morroni Manrico 
Published: May 2020

AbstractThe aim was to analyze the morphology of normal human macula densa (MD), evaluate the cells that may be responsible for its turnover, and collect quantitative data. Of four samples of normal human renal tissue, two were embedded in resin to measure the longitudinal extension and examine the ultrastructure of the MD, the other two were embedded in paraffin to study apoptosis and cell proliferation. The MD is composed of a monolayer tissue about 40 μm long, which includes 35–40 cells arranged in overlapping rows. Ultrastructurally, MD cells show two polarized portions: an apical end, with sensory features, and a basolateral aspect, with paracrine function. MD cells are connected apically by tight junctions, with/without adherens junctions, which form a barrier between the distal tubule lumen and the interstitium. Cells in degeneration, often associated with macrophages, and undifferentiated cells were found in the MD and adjacent distal tubule. A filamentous mat previously described in proximal tubule scattered tubular cells (STCs) was detected in the basal cytoplasm in undifferentiated cells. The tissue was consistently negative for the proliferation marker Ki67 and for the apoptotic markers caspase‐3 and caspase‐9. This work confirms our earlier morphological findings and provides new data: (a) MD cells display both apical adherens and tight junctions, the latter forming a tubulo‐mesangial barrier; (b) the MD is a monolayer made up of about 40 cells arranged in rows; (c) the simultaneous presence of degenerating (8–13%) and undifferentiated (4–13%) cells reminiscent of STCs suggests a non‐negligible cell turnover.
Investigate the layout and age of a large‐scale mausoleum in Hangzhou, China using combined geophysical technologies and archaeological documents
Authors: Shi Zhanjie , Yu Tianxiang , Shi Mengyi 
Published: May 2020

AbstractGeophysical techniques are used to detect mounds and burial chambers, but detecting the shape and layout of large mausoleums containing main tombs and ancillary facilities is a developing field. The shape and layout of mausoleums are closely related to cultural practices. In this study, integrated geophysical technologies were used to survey a large‐scale mausoleum in Hangzhou, China. The layout of the main tomb was deduced from magnetic gradient measurements, and the depth and scale were inferred from electrical resistivity tomography (ERT). The location and burial depth of ancillary facilities, including the mausoleum path, were characterized using the depth (time) slice of ground‐penetrating radar (GPR) three‐dimensional (3D) attribute analysis. An integrated interpretation of geophysical results combined with archaeological documents provides the plan and section layouts of the mausoleum. Based on integrated analyses and archaeological documents, the age of the mausoleum was inferred (middle to late Southern Song Dynasty). Subsequent test excavations partly confirmed the results and showed that the combination of geophysical technologies and archaeological documents are effective and valuable for detecting large‐scale mausoleums.
Achieving Adaptive Aromaticity in Cyclo[10]carbon by Screening Cyclo[n]carbon (n=8−24)
Authors: Dai Chenshu , Chen Dandan , Zhu Jun 
Published: May 2020

AbstractDiscovery of species with adaptive aromaticity (being aromatic in both the lowest singlet and triplet states) is particularly challenging as cyclic species are generally aromatic either in the ground state or in the excited state only, according to Hückel's and Baird's rules. Inspired by the recent realization of cyclo[18]carbon, here we demonstrate that cyclo[10]carbon possesses adaptive aromaticity by screening cyclo[n]carbon (n=8−24), which is supported by nucleus‐independent chemical shift (NICS), anisotropy of the current‐induced density (ACID), π contribution of electron localization function (ELFπ) and electron density of delocalized bonds (EDDB) analyses. Further study reveals that the lowest triplet state of cyclo[10]carbon is formed by in‐plane ππ* excitation. Thus, the major contribution to the aromaticity from out‐of‐plane π molecular orbitals does not change significantly in the lowest singlet state. Our findings highlight a crucial role of out‐of‐plane π orbitals in maintaining aromaticity for both the lowest singlet and triplet states as well as the aromaticity dependence on the number of the carbon in cyclo[n]carbon.
N‐Confused Porphyrin – A Unique “Turn‐On” Chemosensor for CN− and F− ions and “Turn‐Off” Sensor for ClO4− ions
Authors: Grover Nitika , Sankar Muniappan 
Published: May 2020

AbstractN‐Confused meso‐tetrakis(4‐carbomethoxyphenyl)porphyrin (1) and its Ni(II) complex (1 a) have been synthesized and utilized for anion sensing studies, and the results are compared with N‐confused meso‐tetraphenylporphyrin (NCTPP). Anion susceptibilities of 1 and 1 a were investigated using spectroscopic, electrochemical, and DFT studies. Porphyrins 1 and 1 a were able to detect CN−, F−, and ClO4− ions selectively over the tested set of anions even at ppm level. Interestingly, the addition of ClO4− ions resulted in fluorescence quenching (turn off) whereas the addition of F− or CN− resulted in fluorescence enhancement (turn on). Notably, the TFA addition resulted in fluorescence quenching, whereas the fluorescence enhancement was observed while adding TBAOH. The higher association constant (Ka) values with anions, lower detection limit, and shifts in redox potentials are due to the electron‐withdrawing effect of the −COOCH3 group at the para‐position of the meso‐phenyl ring. This electron‐withdrawing nature is crucial for the higher affinity towards anions. The anion sensing description in this article may not only unveil the built‐in nature of N‐confused porphyrins, but may also provide a general proposal for the development of novel anion sensors based on porphyrinoids. The electron‐deficient porphyrin framework, large polarisable π‐system, and anion binding through the outer NH or a combination of the above factors serve as a foundation for N‐confused porphyrin to act as an anion sensor.
Twenty first century changes in Antarctic and Southern Ocean surface climate in CMIP6
Authors: Bracegirdle Thomas J. , Krinner Gerhard , Tonelli Marcos , Haumann F. Alexander , Naughten Kaitlin A. , Rackow Thomas , Roach Lettie A. , Wainer Ilana 
Published: May 2020

AbstractTwo decades into the 21st century there is growing evidence for global impacts of Antarctic and Southern Ocean climate change. Reliable estimates of how the Antarctic climate system would behave under a range of scenarios of future external climate forcing are thus a high priority. Output from new model simulations coordinated as part of the Coupled Model Intercomparison Project Phase 6 (CMIP6) provides an opportunity for a comprehensive analysis of the latest generation of state‐of‐the‐art climate models following a wider range of experiment types and scenarios than previous CMIP phases. Here the main broad‐scale 21st century Antarctic projections provided by the CMIP6 models are shown across four forcing scenarios: SSP1‐2.6, SSP2‐4.5, SSP3‐7.0 and SSP5‐8.5. End‐of‐century Antarctic surface‐air temperature change across these scenarios (relative to 1995–2014) is 1.3, 2.5, 3.7 and 4.8°C. The corresponding proportional precipitation rate changes are 8, 16, 24 and 31%. In addition to these end‐of‐century changes, an assessment of scenario dependence of pathways of absolute and global‐relative 21st century projections is conducted. Potential differences in regional response are of particular relevance to coastal Antarctica, where, for example, ecosystems and ice shelves are highly sensitive to the timing of crossing of key thresholds in both atmospheric and oceanic conditions. Overall, it is found that the projected changes over coastal Antarctica do not scale linearly with global forcing. We identify two factors that appear to contribute: (a) a stronger global‐relative Southern Ocean warming in stabilisation (SSP2‐4.5) and aggressive mitigation (SSP1‐2.6) scenarios as the Southern Ocean continues to warm and (b) projected recovery of Southern Hemisphere stratospheric ozone and its effect on the mid‐latitude westerlies. The major implication is that over coastal Antarctica, the surface warming by 2100 is stronger relative to the global mean surface warming for the low forcing compared to high forcing future scenarios.
The Binding Ability of a Bicyclic Somatostatin Analogue Towards Cu(II) Ions
Authors: Marciniak Aleksandra , Witak Weronika , Pieniężna Aleksandra , Brasuń Justyna 
Published: May 2020

AbstractSomatostatin (SST) analogues have aroused the interest of scientists for years. This group of compounds is used in the diagnosis and treatment of neuroendocrine tumors. However, new molecules useful as radiopharmaceuticals in targeted therapy are still searched for. Bicyclic peptides seem to be very interesting in this context. These molecules are associated with beneficial properties. In this work, we present studies on the binding ability of the bicyclic analogue of somatostatin toward Cu(II) ions which could potentially be a chelator for copper radionuclides. The research is focused on the analysis of Cu(II) interactions with the metal binding cycle of the ligand and the influence of the receptor binding site on the coordination process. This is a novelty in comparison to the SST analogues used in medicine, where a metal ion is coordinated by a chelator and connected with a bioactive molecule by the linker. In this work, we present the first coordination study for a bicyclic ligand. The obtained results showed that the complexes with only imidazole donors are characterized by significantly higher stability in comparison to the other peptides.
Differential mechanisms of autophagy in cancer stem cells: Emphasizing gastrointestinal cancers
Authors: El‐Gowily Afnan H. , Abosheasha Mohammed A. 
Published: May 2020

AbstractGastrointestinal (GI) cancers are one of the most common forms of malignancies and still are the most important cause of cancer‐related mortality worldwide. Autophagy is a conserved catabolic pathway involving lysosomal degradation and recycling of whole cellular components, which is essential for cellular homeostasis. For instance, it acts as a pivotal intracellular quality control and repair mechanism but also implicated in cell reformation during cell differentiation and development. Indeed, GI cancer stem cells (CSCs) are thought to be responsible for tumour initiation, traditional therapies resistance, metastasis and tumour recurrence. Molecular mechanisms of autophagy in normal vs CSCs gain great interest worldwide. Here, we shed light on the role of autophagy in normal stem cells differentiation for embryonic progression and its role in maintaining the activity and self‐renewal capacity of CSCs which offer novel viewpoints on promising cancer therapeutic strategies based on the differential roles of autophagy in CSCs.
Emphysematous cystitis: A case report and literature review
Authors: Mukendi Alain Mwamba 
Published: May 2020

AbstractEmphysematous cystitis is a rare potentially life‐threatening condition and a distinct type of complicated lower urinary tract infection generally associated with diabetes mellitus and diagnosed radiologically. This case report presents a case of emphysematous cystitis as post hiatal hernia repair infectious complication incidentally found on CT abdomen/pelvis.
Boronate Covalent and Hybrid Organic Frameworks Featuring PIII and P=O Lewis Base Sites
Authors: Pacholak Piotr , Gontarczyk Krzysztof , Kamiński Radosław , Durka Krzysztof , Luliński Sergiusz 
Published: May 2020

AbstractTwo covalent organic frameworks comprising Lewis basic PIII centers and Lewis acidic boron atoms were prepared by poly‐condensation reactions of newly obtained tris(4‐diisopropoxyborylphenyl)phosphine with 2,3,6,7,10,11‐hexahydroxytriphenylene and 2,3,6,7‐tetrahydroxy‐9,10‐dimethylanthracene. Obtained materials exhibit significant sorption of dihydrogen (100 cm3 g−1 at 1 bar at 77 K), methane (20 cm3 g−1 at 1 bar at 273 K) and carbon dioxide (50 cm3 g−1 at 1 bar at 273 K). They were exploited as solid‐state ligands for coordination of Pd0 centers. Alternatively, in a bottom‐up approach, boronated phosphine was treated with Pd2dba3 and poly‐condensated, yielding hybrid materials where the polymer networks are formed by means of covalent boronate linkages and coordination P−Pd bonds. In addition, the analogous materials based on phosphine oxide were synthesized. The DFT calculations on framework–guest interactions revealed that the behavior of adjacent boron and phosphorus/phosphine oxide centers is reminiscent of that found in Frustrated Lewis Pairs and may improve sorption of selected molecules.