bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Vitamin B12 Deficiency among Exclusively Breast Fed Term Infants in South India
Authors: Kadiyala Apurva , Palani Anitha , Rajendraprasath Sasitharan , Venkatramanan Padmasani 
Published: November 2020

Abstract

Objective
Vitamin B12 is not synthesized in the body and its only dietary sources are non-vegetarian. The breast milk of mothers in resource poor countries who are on predominantly vegetarian diets is deficient in vitamin B12. Hence exclusive breast feeding (EBF) may result in B12 deficiency in the infant, which can affect the neurodevelopmental outcome. Our aim was to study the serum vitamin B12 levels among EBF infants and identify the risk factors for B12 deficiency.

Method
This cross-sectional study was done among EBF, term, otherwise healthy infants, 1–6 month of age in the well-baby clinic .The sociodemographic data of mother and the infants’ anthropometric measurements were noted and blood samples were sent for complete blood count and serum vitamin B12 levels. The data were analysed using SPSS software version 16.

Results
We enrolled 149 EBF infants, aged 1–6 months and the mean age was 3.1 (±1.03) months. The mean serum vitamin B12 level was 199.91 (±112.523) pg/ml. Low serum vitamin B12 levels (&lt;200 pg/ml) was seen in 95 (63.7%) infants. On multivariate analysis, there were no other significant risk factors for B12 deficiency in the infants.

Conclusion
The prevalence of vitamin B12 deficiency among EBF infants is 63.7%. Because of its importance in neurological development during infancy, there is an urgent need to address this issue while promoting exclusive breast feeding.
Resistance to Azoxystrobin and Thiophanate-Methyl Is Widespread in Colletotrichum spp. Isolates From the Mid-Atlantic Strawberry Fields
Authors: Luo Qiuchen , Schoeneberg Anita , Hu Mengjun 
Published: November 2020

Multiple Colletotrichum species have been found to be responsible for strawberry anthracnose, and prevalence of each species seems to vary by regions and/or host tissues. In this study, a total of 200 Colletotrichum isolates were obtained from different strawberry cultivars displaying anthracnose symptoms in the mid-Atlantic fields. Analysis of g3pdh, tub2, and/or internal transcribed spacer sequences revealed four Colletotrichum species, including C. nymphaeae, C. fioriniae, C. siamense, and C. lineola. C. nymphaeae was the predominant species, representing 90% of all isolates collected. This species was found from all strawberry organs/tissues examined, whereas C. siamense and C. fioriniae were limited to the crown and fruit, respectively. Further, all Colletotrichum isolates were screened for resistance to azoxystrobin in vitro, and all C. siamense isolates were additionally screened for resistance to thiophanate-methyl. The overall frequency of resistance to azoxystrobin and thiophanate-methyl was 48 and 67%, respectively. G143A in the cytochrome b gene was found in all C. nymphaeae and C. siamense isolates with high level of resistance, with EC50 >100 µg/ml, while F129L was found in two of the five C. nymphaeae isolates with moderate resistance, with EC50 values ranging from 2.6 to 7.8 µg/ml. All C. fioriniae isolates tested were found to be less sensitive to azoxystrobin, with EC50 values ranging from 9.7 to 14.4 µg/ml, despite no mutations detected in the cytochrome b gene. Moreover, E198A in tub2 was linked with C. siamense isolates resistant to thiophanate-methyl (EC50 >100 µg/ml). These results revealed that resistance in Colletotrichum spp. to primary fungicides is widespread in the mid-Atlantic strawberry fields.
Effect of Oral Carbohydrate Intake During Labor on the Rate of Instrumental Vaginal Delivery: A Multicenter, Randomized Controlled Trial
Authors: Simonet T. , Gakuba C. , Desmeulles I. , Corouge J. , Beucher G. , Morello R. , Gérard J.L. , Ducloy-Bouthors A.S. , Dreyfus M. , Hanouz J.L. 
Published: November 2020

(Anesth Analg. 2020;30:1670–1677)Mendelson’s description of gastric fluid inhalation led to the practice of starving pregnant women during labor. Contrary to this practice, however, fluid consumption during labor has been shown to be safe and feasible. No definitive evidence exists to support food and fluid restriction during low-risk labors, unless a cesarean delivery (CD) becomes likely. In fact, the food and fluid restriction has been shown to create a shift toward the anaerobic pathway of glucose metabolism, despite a high glycogen content and turnover in the myometrium, thereby suggesting a relative energy shortage. This shortage may explain a commonly observed production of ketone bodies during labor, which results from fat metabolism following glycogen storage depletion. Ketosis during labor can be prevented by either allowing women in labor a light diet, or by allowing caloric intake via isotonic sports drinks. Ketosis and exhaustion can lead to a need for instrumental vaginal delivery when fatigue or inadequate progress develop during labor. The authors of this study hypothesized that carbohydrate intake, such as consuming isotonic sports drinks during labor, could reduce the instrumental vaginal delivery rate.
Transcatheter closure of a rare congenital left ventricle to right atrium shunt using the amplatzer duct occluder II
Authors: Shi Xiaoqing , Wang Kaiyang , Li Jinhui , Wu Jinlin , Zhou Kaiyu , Hua Yimin , Li Yifei 
Published: November 2020

Abstract

Rationale:
Left ventricle-right atrium (LV-RA) shunt is a rare case and surgical repair has been the routine procedure to correct this defect. With the rapid development of transcatheter technology, some of the cases can be closed with transcatheter technique. Here, we would like to report a congenital LV-RA case who received transcatheter closure using the Amplazter duct occluder II (ADO II) and the short-term outcomes of this procedure.

Patient concerns:
A 2-year-old female presented a systolic murmur between the 2nd to 3rd sternal rib during the routine examination before kindergarten administration.

Diagnosis:
The patient denied any cardiac surgery, endocarditis, trauma or cardiomyopathy. The echocardiography confirmed an abnormal shunt between left ventricle and right atrium located in the superior part of ventricular septum which is closed to septal tricuspid valve and anterior mitral valve, and the diameter of this shunt is 2 mm. Besides, the dilation of right atrium (40 mm) has been identified which was not a common clinical manifestation of typical ventricular septal defect. Angiography demonstrated the shunt driven from left ventricle to right atrium.

Intervention:
An AGA ADO II device had been delivered to close the defect.

Outcome:
Follow-up kept for 3 months. Echocardiography revealed completed closure of the shunt with normal movement and function valves. And no complication of arrhythmia has been recorded.

Lessons:
This case report highlighted the administration of ADO II in some ventricular septal defect with superior location, and provided an essential experience of using ADO II to close long tunnel type LV-RA shunt.
Comprehensive analysis of the expression and prognosis for S100 in human ovarian cancer
Authors: Xu Hong-Yu , Song Hua-Mei , Zhou Quan 
Published: November 2020

Abstract
S100 family members are frequently deregulated in human malignancies, including ovarian cancer. However, the prognostic roles of each individual S100 family member in ovarian cancer (OC) patients remain elusive. In the present study, we assessed the prognostic roles and molecular function of 20 individual members of the S100 family in OC patients using GEPIA, Kaplan–Meier plotter, SurvExpress, GeneMANIA and Funrich database. Our results indicated that the mRNA expression levels of S100A1, S100A2, S100A4, S100A5, S100A11, S100A14, and S100A16 were significantly upregulated in patients with OC, and high mRNA expression of S100A1, S100A3, S100A5, S100A6, and S100A13 were significantly correlated with better overall survival, while increased S100A2, S100A7A, S100A10, and S100A11 mRNA expressions were associated with worse prognosis in OC patients. In stratified analysis, the trends of high expression of individual S100 members were nearly the same in different pathological grade, clinical stage, TP53 mutation status, and treatment. More importantly, S100 family signatures may be useful potential prognostic markers for OC. These findings suggest that S100 family plays a vital role in prognostic value and could potentially be an S100-targeted inhibitors for OC patients.
Comparative efficacy and safety of injection therapies for knee osteoarthritis
Authors: Yu Ting , Yan ShiFan , Chi ZhenHai , Zhu DaoCheng , Cheng Pan , Li HaiYan , Qin SiYu , Zhong GenPing , Ouyang XiLin , Chen RiXin , Jiao Lin 
Published: November 2020

Abstract

Introduction:
There are many injection methods for the treatment of knee osteoarthritis, but there is no comprehensive comparison, based on the fixed effect model.

Methods:
According to the retrieval strategy, we searched randomized controlled trials (RCTs) randomly from PubMed, the Cochrane Library, Embase, the China National Knowledge Infrastructure (CNKI), Wanfang Database from their inceptions to August 2020, and 2 members of us selected literatures and extracted data independently. Methodological quality was assessed by using the Cochrane bias risk tool, and meta-analysis was performed by using the Stat.14.0.

Results:
This study will evaluate the effectiveness and safety of different injectable drugs for the treatment of knee osteoarthritis and rank the efficacies of drugs, then to determine the optimal treatment.

Conclusion:
This study will provide evidence for the choice of injection therapy for knee osteoarthritis.

INPLASY registration number:
INPLASY202080099.
Improving segmentation accuracy of CT kidney cancer images using adaptive active contour model
Authors: Hsu Wei-Yen , Lu Chih-Cheng , Hsu Yuan-Yu 
Published: November 2020

Abstract
In the present study, we retrospectively analyzed the records of surgical confirmed kidney cancer with renal cell carcinoma pathology in the database of the hospital. We evaluated the significance of cancer size by assessing the outcomes of proposed adaptive active contour model (ACM). The aim of our study was to develop an adaptive ACM method to measure the radiological size of kidney cancer on computed tomography in the hospital patients. This paper proposed a set of medical image processing, applying images provided by the hospital and select the more obvious cases by the doctors, after the first treatment to remove noise image, and the kidney cancer contour would be circled by using the proposed adaptive ACM method. The results showed that the experimental outcome has highly similarity with the medical professional manual contour. The accuracy rate is higher than 99%. We have developed a novel adaptive ACM approach that well combines a knowledge-based system to contour the kidney cancer size in computed tomography imaging to support the clinical decision.
Characteristics and risk factors for extrauterine growth retardation in very-low-birth-weight infants
Authors: Zhao Xingli , Ding Li , Chen Xiaoqian , Zhu Xueping , Wang Jian 
Published: November 2020

Abstract

Background:
To investigate the characteristics and risk factors for extrauterine growth retardation (EUGR) in very-low-birth-weight infants (VLBWIs).

Methods:
The medical records of 137 VLBWIs admitted to the neonatal intensive care unit between June 2015 and December 2017 were retrospectively reviewed. The patients were divided into EUGR (n = 92) and non-EUGR (n = 45) groups. This study collected data on demographic and clinical characteristics and analyzed the risk factors for EUGR with multivariate logistic regression.

Results:
Gestational age (OR = 0.573, P < .01), SGA (OR = 3.887, P = .022), feeding intolerance (OR = 4.632, P = .002), and calories supplied by amino acids at the 7th day (OR = 0.786, P = .006) were high-risk factors for EUGR.

Conclusion:
Feeding intolerance reduction and amino acid nutrition support should be applied to prevent delayed extrauterine growth for VLBWIs.
A bibliometric analysis of the 100 most influential papers on peritoneal dialysis
Authors: Yuan Xinke , Li Hui , Zhou Luting , Huang Yinghong 
Published: November 2020

Abstract

Background:
We aimed to identify the 100 most cited articles published on peritoneal dialysis (PD) and analyze their characteristics to provide information on the achievements and developments of PD research over the past decades.

Methods:
The Science Citation Index Expanded (SCIE) in the Web of Science Core Collection was comprehensively searched from 2000 to 2018, using the keywords “Peritoneal dialysis” or “Dialyses, Peritoneal” or “Dialysis, Peritoneal” or “Peritoneal Dialyses”. The top 100 cited articles were retrieved by reading titles and abstracts. Significant information was further elicited, including the authors, journals, countries, institutions, and publication year.

Results:
The United States was the most productive country (n = 51), Li Pkt published the highest number of papers (n = 7), the Journal of the American Society of Nephrology produced the highest number of contributions (n = 28), and Baxter International Inc., the University of California System, and the University of Toronto were the institutions with the highest number of articles (n = 10).

Conclusions:
This is the first bibliometric study to identify the most influential papers in PD research. This report describes the major changes and advances in research regarding PD as a guide for writing a citable article.
Zhisou powder in treatment of postinfectious cough
Authors: Cai Haiyang , Li Weihong , Kang Shixin , He Jing , Yu Peng , Li Han 
Published: November 2020

Abstract

Background:
The pathogensis of postinfectious cough (PIC) is unkown, unsatisfactory clinical curative effects of conventional western medicine have been shown. Zhisou powder (ZP) is one of the most common prescriptions in traditional Chinese medicine for the treatment of PIC. However, the effects and safety also remain uncertain. We aim to systematically review the effectiveness and safety of ZP for PIC.

Methods:
We will search the following databases: PubMed, Embase, Cochrane Library, MEDLINE, the China National Knowledge Infrastructure , the Chinese Biomedical Literature Database, Cqvip Database, and Wanfang Data. The studies published from the inception of the database to May 2020 will be retrieved. The randomized controlled trials on ZP for PIC will be included. The primary outcomes were cough relief rate and cough resolution rate. We will perform the analyses using RevMan V.5.3 software.

Results:
This study will provide high-quality evidence of ZP for PIC in the effectiveness and safety.

Conclusions:
This systematic review will assess whether ZP is an effective and safe prescription for PIC.
A retrospective study of in-hospital mortality in patients with idiopathic pulmonary fibrosis between 2015 and 2018
Authors: Durheim Michael T. , Judy Jennifer , Bender Shaun , Neely Megan L. , Baumer Dorothy , Robinson Scott B. , Conoscenti Craig S. , Leonard Thomas B. , Lazarus Howard M. , Palmer Scott M. 
Published: November 2020

Abstract
Hospitalizations are common in patients with idiopathic pulmonary fibrosis (IPF) and are associated with high mortality. We used data from the Premier Healthcare Database to determine in-hospital mortality rates and the factors associated with in-hospital mortality in patients with IPF in the era of approved antifibrotic drugs.
The Premier Healthcare Database is a detailed and broadly representative database of hospital admissions and discharges in the US. Patients with IPF who were hospitalized between 1 January 2015 and 28 February 2018 were identified using a diagnostic algorithm comprising International Classification of Diseases -9 and International Classification of Diseases -10 diagnostic codes and billing data. Associations between patient-, hospital- and treatment-related factors and a composite outcome of death during the index visit, lung transplant during the index visit but >1 day after admission, or death during a readmission within 90 days of the index visit were analyzed using logistic regression.
The cohort comprised 9667 hospitalized patients with IPF. In total, 1414 patients (14.6%) met the composite outcome: 1036 (10.7%) died during the index visit, 371 (3.8%) died during a readmission within 90 days; 7 (0.1%) underwent lung transplant >1 day after admission. Factors significantly associated with a higher risk of the composite outcome included mechanical ventilation (odds ratio 6.41 [95% CI: 5.24, 7.84]), admission to the intensive care unit (1.73 [1.49, 2.00]), attendance by a critical care physician (2.12 [1.33, 3.38]), older age (1.20 [1.12, 1.28] per 10-year increase), and use of intravenous steroids (1.16 [1.00, 1.34]), intravenous antibiotics (1.49 [1.22, 1.83]) and opioids (3.41 [2.95, 3.93]). Factors significantly associated with a lower risk of the composite outcome included female sex (0.70 [0.61, 0.80]), comorbid chronic obstructive pulmonary disease (0.69 [0.60, 0.78]), attendance by a family medicine physician (0.67 [0.48, 0.94]) or internal medicine physician (0.59 [0.46, 0.75]), and use of oral steroids (0.62 [0.51, 0.77]), statins (0.76 [0.67, 0.87]) and proton pump inhibitors (0.80 [0.70, 0.92]).
In conclusion, patients with IPF are at risk of mortality during a hospital stay or readmission within 90 days, particularly those who receive mechanical ventilation.
Efficacy of belt electrode skeletal muscle electrical stimulation on muscle flexibility of lower limbs
Authors: Tomida Kouki , Nakae Hajime 
Published: November 2020

Abstract

Background:
Muscular contracture may be caused by immobility-induced muscle atrophy and skeletal muscle hypoxia. Belt electrode skeletal muscle electrical stimulation (B-SES) is a new type of neuromuscular electrical stimulation that can simultaneously contract the lower limb muscle groups, in contrast to the conventional pad-type electrodes. B-SES can suppress muscular atrophy and relieve hypoxia of the skeletal muscle and is considered an appropriate strategy for preventing muscular contracture. However, the effect of B-SES on muscle flexibility has not been verified. This study aimed to compare the immediate effects of B-SES on skeletal muscle flexibility using different stimulation modes before the clinical study.

Methods:
We conducted a randomized controlled pilot trial with cross-over analysis of 10 healthy subjects. The participants were subjected to three stimulus conditions (Disuse B-SES, Metabolic B-SES, and Control) with a minimal interval of 1 day between interventions, and the lower limb flexibility before and after the B-SES intervention was evaluated. Lower extremity flexibility was evaluated based on the hamstring muscle stiffness and sit-and-reach distance. For each endpoint, within-group comparisons were performed before and after the intervention and were compared between the groups using paired t-tests. Changes in each endpoint before and after the intervention were analyzed using repeated-measures analysis of variance and the Bonferroni method. The significance level was 0.05.

Results:
Ten healthy individuals participated in all three interventions with a washout period between each intervention. In the Metabolic B-SES group, the sit-and-reach distance after the intervention was significantly higher than that before the intervention (P < 0.05). A comparison of the change in the sit-and-reach distance among the three groups before subsequent tests showed that the Metabolic B-SES group had a significantly increased sit-and-reach distance compared with the control group (P < 0.05).

Conclusion:
Metabolic B-SES was effective for the immediate improvement of flexibility of the lower limb muscles. Therefore, Metabolic B-SES may be useful as a strategy for preventing muscular contracture.
Review of psychiatric comorbidities and their associations with opioid use in elective lumbar spine surgery
Authors: Mezzacappa Frank M. , Schmidt Kyle P. , Tenny Steven O. , Samson Kaeli K. , Agrawal Sandeep K. , Hellbusch Leslie C. 
Published: November 2020

Abstract
The opioid epidemic is an ongoing concern in the United States and efforts to ameliorate this crisis are underway on multiple fronts. Opiate use is an important consideration for patients undergoing lumbar spine surgery with concurrent psychiatric diagnoses and more information is needed regarding the factors involved in these patients. That information may help guide opioid prescribing practices for individual patients with certain psychiatric conditions that are undergoing these procedures. This study was done to identify psychiatric conditions that are associated with preoperative and postoperative opioid use in this cohort of veteran patients undergoing elective lumbar spine surgery.
A 3 month preoperative and 3 month postoperative chart review was conducted on 25 patients per year who underwent elective lumbar spine surgery over a 16-year period at the Veterans Affairs Nebraska-Western Iowa Healthcare Center (n = 376 after exclusion criteria applied). The association between psychiatric comorbidities and use of opioids during the 90-day period after surgery was assessed using a linear model that adjusted for surgical type, opioid use prior to surgery, and other relevant comorbidities.
Patients are more likely to use opioids preoperatively if they have major depression (P = .02), hepatitis C (P = .01), or musculoskeletal disorders (P = .04). PTSD (P = .02) and lumbar fusion surgery (P < .0001) are associated with increased postoperative use, after adjusting for preoperative use and other comorbidities.
Certain psychiatric comorbidities are significantly correlated with opioid use for this cohort of lumbar spine surgery patients in the preoperative and postoperative periods. Awareness of an individual's psychiatric comorbidity burden may help guide opioid prescription use.
Reduction in SLEDAI is associated with improved arterial stiffness in systemic lupus erythematosus
Authors: Du Tian , Pang Haiyu , Ding Faming , Ye Yicong , Li Mengtao , Yang Xufei , Zhang Yang , Zeng Xiaofeng , Zhang Shuyang 
Published: November 2020

Abstract
Lipid abnormalities are an important cause of premature atherosclerosis in patients with systemic lupus erythematosus (SLE). This longitudinal study investigates the changes in lipid profile and arterial stiffness with SLE disease activity index (SLEDAI) reduction.
Fifty one female SLE patients with baseline SLEDAI ≥ 6 and SLEDAI reduction >3 at 1-year follow-up were included. Neutrophil-to-lymphocyte ratio (NLR), erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hsCRP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), and mean brachial-ankle pulse wave velocity (baPWV) were measured and compared between baseline and 1-year follow-up. Correlations between inflammation biomarkers, SLEDAI, mean baPWV and lipid profile were assessed.
We observed significant decreases in ESR, mean baPWV, TG and TC to HDL-C ratio compared with baseline at 1-year follow up, while HDL-C, hsCRP, and NLR were not significantly changed. Significant correlations were found between the reductions in ESR and TG, and SLEDAI and mean baPWV, with adjustment to age, disease duration, blood pressure, and medications (prednisone, immunosuppressants and ARB/ACEI).
SLE patients experiencing SLEDAI reductions showed improvements in arterial stiffness. This finding may provide insight into the beneficial effects of reducing SLEDAI on atherosclerosis risk in SLE.