bluuebunny/crossref_metadata_2025_split huggingface dataset:
SIMULAÇÃO NUMÉRICA DA ADVECÇÃO-DIFUSÃO UNIDIMENSIONAL EMPREGANDO UM MODELO COM DERIVADAS FRACIONÁRIAS
Authors: Scotton Jaque Willian , Suarez Julian Moises Sejje , Goulart Antonio Gledson Oliveira 
Published: July 2020

Neste trabalho, apresentamos os resultados obtidos na realização de simulações numéricas do problema estacionário de advecção-difusão unidimensional considerando, diferentemente da maioria dos trabalhos reportados na literatura, uma modelagem numérica baseada na equação da advecção-difusão com derivadas de ordens fracionárias. Para a realização do estudo, foram empregadas derivadas fracionárias de ordem ? conforme a definição de Riemann-Liouville, discretizadas numericamente pelo Método das Diferenças Finitas, utilizando a fórmula de Grünwald-Letnikov, com o objetivo de verificar a influência das ordens das derivadas nos perfis de solução de um problema sujeito a condições de contorno de Dirichlet, com velocidade constante e com coeficiente de difusão variável. Os valores considerados para as ordens das derivadas foram números reais pertencentes ao intervalo (0,1), tendo a modelagem fracionária sido validada com base na solução anal?tica para um caso espec?fico onde ? = 1. Nesse procedimento, fez-se a ordem das derivadas fracionárias ser muito próxima de 1 esperando que os resultados numéricos obtidos fossem muito próximos dos resultados analíticos para o caso inteiro, o que de fato foi constatado, validando a modelagem. Os resultados obtidos para as demais situações analisadas evidenciaram que os valores de concentração, C, ao longo do dom?nio tornam-se menores quanto menores forem as ordens das derivadas.
Assessment of land cover resolution impact on flood modeling uncertainty
Authors: Fan Jihui , Galoie Majid , Motamedi Artemis , Huang Jing 
Published: July 2020

AbstractThe main objective of this paper is to evaluate the impact of land cover resolution, in comparison with the digital elevation model (DEM) resolution, on hydrological modeling outputs. Three different basins in the various resolutions of DEM (12.5, 25, 50, 100, 500 and 1,000 m) and land-use maps (250, 1,000 and 2,500 m) were collected in this study, and the hydrological modeling process was performed using the Soil and Water Assessment Tool (SWAT) model. The soil type resolution was 1,000 m for all basins, and the runoff modeling was done based on the Soil Conservation Service Curve Number (SCS-CN) method. The final model outputs showed that the DEM cell size variations affect significantly the topographical characteristics of a catchment such as area, mean slope, river network and time to concentration which alter the flood modeling outputs especially in hilly watersheds (mean slope more than 15%) up to 15% for a DEM cell size of 1,000 m in comparison to 12.5 m. Also, the resolution and spatial distribution of land cover maps which directly specify SCS-CN values, can change the output simulated runoff results up to 49% for a land cover cell size of 2,500 m in comparison to 250 m. These results indicated that the quality of the land cover map is more important than the quality of DEM in hydrological modeling. Also, the results showed that for an identical land-use cell size, the differences between model outputs using DEM cell sizes less than 100 m were not very significant. Furthermore, in all models by increasing the DEM cell size, the simulated runoff depth was decreased.
Development of an assessment tool for infrastructure asset management of urban drainage systems
Authors: Igroufa Meriem , Benzerra Abbas , Seghir Abdelghani 
Published: July 2020

Abstract
The present paper deals with the improvement of infrastructure asset management of urban drainage systems (UDS). A numerical tool for assessing the existing management procedures is proposed. It is based on a participatory methodology for the construction of a set of performance indicators. This methodology consists of two phases. The first concerns the identification of priority objectives, criteria and indicators related to the management of the UDS infrastructure. The second phase concerns the assessment of the global performance for each identified objective. Performance measurement scales are first defined for all the elements of the proposed methodology. Then, the Fuzzy Analytical Hierarchy Process (FAHP) is used for the weighting stage, and the Weighted Sum Method is used for the aggregation of indicators and criteria. To illustrate this methodology, a case study concerning Bejaia City in northern Algeria was carried out. Two priority objectives are identified for this case, they are divided into 6 criteria and 31 indicators. The results of the application of the developed tool highlighted some weaknesses that need improvements in the actual management procedure applied by the local sanitation services.
Exosomes: Structure, Biogenesis, Types and Application in Diagnosis and Gene and Drug Delivery
Authors: Agarwal Shriya , Agarwal Vinayak , Agarwal Mugdha , Singh Manisha 
Published: July 2020

Abstract:
In recent times, several approaches for targeted gene therapy (GT) had been studied. However,
the emergence of extracellular vesicles (EVs) as a shuttle carrying genetic information between
cells has gained a lot of interest in scientific communities. Owing to their higher capabilities in dealing
with short sequences of nucleic acid (mRNA, miRNA), proteins, recombinant proteins, exosomes, the
most popular form of EVs are viewed as reliable biological therapeutic conveyers. They have natural
access through every biological membrane and can be employed for site-specific and efficient drug
delivery without eliciting any immune responses hence, qualifying as an ideal delivery vehicle. Also,
there are many research studies conducted in the last few decades on using exosome-mediated gene
therapy into developing an effective therapy with the concept of a higher degree of precision in gene
isolation, purification and delivery mechanism loading, delivery and targeting protocols. This review
discusses several facets that contribute towards developing an efficient therapeutic regime for gene
therapy, highlighting limitations and drawbacks associated with current GT and suggested therapeutic
regimes.
Polymeric Precipitation Inhibitor Assisted Supersaturable SMEDDS of Efavirenz Based on Experimental Observations and Molecular Mechanics
Authors: Singh Manmeet , Singh Dilpreet , Mahajan Sundar , Sheikh Bilal Ahmed , Bedi Neena 
Published: July 2020

Background:
Supersaturable SMEDDS, a versatile dosage form, was investigated for improving
the biopharmaceutical attributes and eradicating the food effect of poorly water soluble drug
efavirenz.

Objective:
The present research pursues development of efavirenz loaded supersaturable self-microemulsifying drug delivery system (SS SMEDDS) for improving biopharmaceutical performance.

Methods:
Preformulation studies were carried out to determine the optimized range of lipid excipients
to develop stable supersaturated SMEDDS (ST SMEDDS). The SS SMEDD formulation was prepared
by adding hydroxypropyl methylcellulose as a polymeric precipitation inhibitor. The developed SS
SMEDDS were evaluated for supersaturation behavior by performing in vitro supersaturation studies
and molecular simulations by in silico docking. Dissolution was performed in biorelevant media to simulate
fed/fasted conditions in gastrointestinal regions. Absorption behavior was determined through in
vivo pharmacokinetics approach.

Results:
The optimized ST SMEDDS formulation containing Maisine® CC, Tween 80 and Transcutol-P
exhibited thermodynamic stability with quick rate of emulsification. The optimized SS SMEDDS containing
suitable polymeric precipitation inhibitor exhibited enhanced efavirenz concentration in in vitro
supersaturation test. The theoretical simulations by molecular docking revealed strong intermolecular
interactions with a docking score of -3.004 KJ/mol. The dissolution performance of marketed product in
biorelevant dissolution media inferred the existence of food effect in the dissolution of efavirenz. However,
in SS SMEDDS, no significant differences in drug release behavior under different fasted/fed
conditions signify that the food effect was neutralized. In vivo pharmacokinetics revealed a significant
increase in the absorption profile of efavirenz from SS SMEDDS than that of ST SMEDDS and marketed
product.

Conclusion:
The designed delivery system indicated promising results in developing an effectual EFV formulation for HIV
treatment.
Drug Re-purposing from SARS-CoV Led the Identification of Potential Candidate Drug Target and Alternate Drug Molecules Against SARSCoV- 2
Authors: Arun PV Parvati Sai , Hussain Razak , Akhter Yusuf , Rao Mandava Venkata Basaveswara , Shyam Perugu , Yellaboina Sailu 
Published: July 2020

Background:
SARS-CoV-2 causes COVID19 disease where there are no suitable drugs
available.

Objective:
The objective of the work is to repurpose the drugs prescribed for SARS-CoV as the
drugs for the control of SARS-CoV-2.

Methods::
In this work, we have used homology searches and docking methods for understanding
the mechanism of the drugs prescribed for the control of SARS-CoV on SARS-CoV-2.

Results:
In our analysis, we found that the drugs Benzyl (2-Oxopropyl)carbamate, 2-[(2,4-Dichloro-
5-methyl phenyl)sulfonyl]-1,3-dinitro-5-(trifluoromethyl)benzene, S-[5-(Trifluoromethyl)-4H-1,2,4-
triazol-3-YL] 5-(phenylethynyl)furan-2-carbothioate, 4-(Dimethylamino)benzoic acid, which are
capable of inhibition of the activity of 3CLPro and prevent the progression of SARS-CoV.

Conclusion:
In this letter, we describe the findings of the protein ligand interactions between 3CLPro
of SARS-CoV, SARS-CoV-2 with Benzyl (2-oxopropyl) carbamate.
Spontaneous Adverse Drug Reaction Monitoring in a Tertiary Care Centre
Authors: Kaur Kirandeep , Kanwal Preet , Goyal Pardeep , Singh Paramjit , Yakhmi Sahil , Jain Samriti , Kaushal Sandeep 
Published: July 2020

Background and Objective:
Adverse drug reactions (ADRs) are associated with increased
economic burden on the society. Monitoring of ADRs can help in decreasing the incidence
of preventable adverse reactions.

Methods:
Under Pharmacovigilance Program of India, collection and reporting of ADRs has been
going on at Dayanand Medical College and Hospital since January 2011. Here, we have analyzed
the individual case safety reports (ICSRs) reported and uploaded between January 2017 and June
2019 from our centre. The ADR form provided by PvPI was used for collecting information, and
the causality assessment was done according to the WHO-UMC scale.

Results:
A total of 498 ICSRs were uploaded through Vigiflow software during this period. Highest
number of ADRs were recorded in the age group of 31-45 years (29.01%) and the least number of
ADRs were recorded in the children less than 15 years of age (6.76%). General Medicine ward reported
the highest number of ADRs and the antibiotics were most commonly associated with ADRs
(26.21%), followed by antipsychotics (13.83%) and NSAIDs (12.14%). More than 90% of ADRs
were non-serious (93.17%) and most of the ADRs were skin and soft tissue related (49.20%).

Conclusion:
Spontaneous reporting among indoor patients shows highest number of ADRs with use
of antibiotics and almost all of the ADRs were non-serious in nature. Almost half of the total ADRs
were skin and subcutaneous tissue related. Continuous efforts are required for further strengthening
of the pharmacovigilance program of India.
Superior Mesenteric Venous (SMV) Thrombosis Accompanied with Appendicitis in a Patient with Primary Diagnosis of Typhoid Fever
Authors: Adibimehr Alireza , SeyedAlinaghi SeyedAhmad , Nourian Anahid , Mehrabi Zeinab , Moslemi Rohollah 
Published: July 2020

Background:
Septic thrombophlebitis of the Superior Mesenteric Venous (SMV) is rarely
accompanied by appendicitis, and symptoms are atypical, so the diagnosis is commonly delayed,
resulting in it is associated with high mortality.

Case Presentation:
We report a case of neglected SMV septic thrombophlebitis is caused by appendicitis.
The patient represented with fever, vague abdominal pain without rebound tenderness, and
history of the consumption of contaminated water. Antibiotic initiated due to suspicious typhoid
fever. Then typhoid fever was ruled out. Computed tomography (CT) scans revealed micro-abscess
forming complicated appendicitis and the thrombus in SMV.

Discussion and Conclusion:
The patient underwent a laparoscopic appendectomy, during which
retrocecal gangrened perforated appendix with a 2×2 cm abscess was drained. Based on positive
culture with ESBL organism meropenem was initiated. Appendectomy and treatment with broad-
-spectrum antibiotics and anticoagulation led to a full recovery.
Suitable Signal Peptides for Secretory Production of Recombinant Granulocyte Colony Stimulating Factor in Escherichia coli
Authors: Tehrani Sadra S. , Goodarzi Golnaz , Naghizadeh Mohsen , Khatami Seyyed H. , Movahedpour Ahmad , Abbasi Ali , Shabaninejad Zahra , Khalaf Nesa , Taheri-Anganeh Mortaza , Savardashtaki Amir 
Published: July 2020

Background:Granulocyte colony-stimulating factor (G-CSF) expressed in engineered Escherichia coli (E. coli) as a recombinant protein is utilized as an adjunct to chemotherapy for improving neutropenia. Recombinant proteins overexpression may lead to the creation of inclusion bodies whose recovery is a tedious and costly process. To overcome the problem of inclusion bodies, secretory production might be used. To achieve a mature secretory protein product, suitable signal peptide (SP) selection is a vital step.Objective:In the present study, we aimed at in silico evaluation of proper SPs for secretory production of recombinant G-CSF in E. coli.Methods:Signal peptide website and UniProt were used to collect the SPs and G-CSF sequences. Then, SignalP were utilized in order to predict the SPs and location of their cleavage site. Physicochemical features and solubility were investigated by ProtParam and Protein-sol tools. Fusion proteins sub-cellular localization was predicted by ProtCompB.Results:LPP, ELBP, TSH, HST3, ELBH, AIDA and PET were excluded according to SignalP. The highest aliphatic index belonged to OMPC, TORT and THIB and PPA. Also, the highest GRAVY belonged to OMPC, ELAP, TORT, BLAT, THIB, and PSPE. Furthermore, G-CSF fused with all SPs were predicted as soluble fusion proteins except three SPs. Finally, we found OMPT, OMPF, PHOE, LAMB, SAT, and OMPP can translocate G-CSF into extracellular space.Conclusion:Six SPs were suitable for translocating G-CSF into the extracellular media. Although growing data indicate that the bioinformatics approaches can improve the precision and accuracy of studies, further experimental investigations and recent patents explaining several inventions associated to the clinical aspects of SPs for secretory production of recombinant GCSF in E. coli are required for final validation.
Enhanced Solubility and Permeability of Naringenin Across Non-Everted Sacs of Rat Small Intestine by Lipid Nanocapsules
Authors: Vakilzadeh Hamed , Varshosaz Jaleh , Soghrati Sahel 
Published: July 2020

Background:
Naringenin (NRG) has many health benefits, including; anti-atherogenic, antiinflammatory,
antitumor, and anticancer activity, as well as improvement of lipid metabolism. However,
its use is limited due to its low solubility and bioavailability.

Objectives:
The aim of the present patent study was the preparation and optimization of NRG loaded
Novel Lipid Nanocapsules (LNCs) for the improvement of NRG solubility and gut permeability.

Methods:
Studied variables included; Solutol® HS15 and NRG concentration and the ratio of cold diluent
water to primary emulsion. The storage stability of the LNCs was evaluated for 32 days and thermal
analyses were conducted by Differential Scanning Calorimetry (DSC). The antioxidant properties
of the NRG in LNCs were studied by measuring the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) free radical
scavenging activity. The enhancement of permeation of NRG by the LNCs from the intestine was
evaluated by the non-everted gut sac method.

Results:
The optimized NRG-LNCs had a hydrodynamic diameter of 29.41±1.25 nm, a low polydispersity
index, and high entrapment efficiency of 99.25±2.31%. The LNCs could retain NRG radical
scavenging activity, showed good storage stability, and significantly improved NRG solubility (69
fold) and permeation through non-everted rat intestinal sac (4.33 fold).

Conclusion:
LNCs of NGR enhance solubility and intestinal permeability of this flavonoid and may be
useful in the improvement of its bioavailability.
Role of Deposition Pressure on Properties of Phosphorus Doped Hydrogenated Nano-Crystalline Silicon (nc-Si:H) Thin Films Prepared by the Cat-CVD Method
Authors: Gabhale Bharat , Waghmare Ashish , Pandharkar Subhash , Bhorde Ajinkya , Nair Shruthi , Vairale Priti , Doiphode Vidya , Shinde Pratibha , Punde Ashvini , Hase Yogesh , Patil Nilesh , Prasad Mohit , Jadkar Sandesh 
Published: July 2020

Objective:
Phosphorus doped hydrogenated nano-crystalline silicon (nc-Si:H) thin
films were synthesized by catalytic chemical vapor deposition (Cat-CVD) method.

Methods:
The effect of deposition pressure on opto-electronic and structural properties was
studied using various analysis techniques such as low angle XRD analysis, FTIR spectroscopy,
Raman spectroscopy, UV-Visible spectroscopy, dark conductivity, etc.

Results:
From low angle XRD and Raman spectroscopy analysis, it is observed that an increase
in deposition pressure causes Si:H films to transform and transit from amorphous to
the crystalline phase. At optimized deposition pressure (300 mTorr), phosphorous doped nc-
Si:H films having a crystallite size of ∼29 nm and crystalline volume fraction of ∼58% along
with high deposition rate (∼29.7 Å/s) have been obtained. The band gap was found to be
∼1.98 eV and hydrogen content was as low as (∼1.72 at. %) for these films.

Conclusion:
The deposited films can be useful as an n-type layer for Si:H based p-i-n,
tandem and c-Si hetero-junction solar cells.
A Tool for Rating the Value of Health Education Mobile Apps to Enhance Student Learning (MARuL): Development and Usability Study
Authors: Gladman Tehmina , Tylee Grace , Gallagher Steve , Mair Jonathan , Rennie Sarah C , Grainger Rebecca 
Published: July 2020

Background
To realize the potential for mobile learning in clinical skills acquisition, medical students and their teachers should be able to evaluate the value of an app to support student learning of clinical skills. To our knowledge, there is currently no rubric for evaluation of quality or value that is specific for apps to support medical student learning. Such a rubric might assist students to be more confident in using apps to support their learning.

Objective
The objective of this study was to develop an instrument that can be used by health professional educators to rate the value of a mobile app to support health professional student learning.

Methods
Using the literature, we developed a list of potential criteria for the evaluation of educational app value, which were then refined with a student group using a modified nominal group technique. The refined list was organized into themes, and the initial rubric, Mobile App Rubric for Learning (MARuL, version 1), was developed. iOS and Android app stores were searched for clinical skills apps that met our inclusion criteria. After the 2 reviewers were trained and the item descriptions were refined (version 2), a random sample of 10 included apps, 5 for each mobile operating system, was reviewed. Interitem and interrater analyses and discussions with the reviewers resulted in refinement of MARuL to version 3. The reviewers completed a review of 41 clinical skills mobile apps, and a second round of interitem and interrater reliability testing was performed, leading to version 4 of the MARuL.

Results
Students identified 28 items (from an initial set of 144 possible items) during the nominal group phase, and these were then grouped into 4 themes: teaching and learning, user centered, professional, and usability. Testing and refinement with reviewers reduced the list to 26 items. Internal consistency for MARuL was excellent (α=.96), and the interrater reliability as measured by the intraclass correlation coefficient (ICC) was good (ICC=0.66).

Conclusions
MARuL offers a fast and user-friendly method for teachers to select valuable apps to enhance student learning.
THE FUNCTION OF HARMONY IN MUSICAL DRAMATURGY: SONGS OF HADŽI TOMA AND ALIL IN THE MUSIC DRAMA KOŠTANA BY PETAR KONJOVIC
Authors: Milenkovic Marko S. 
Published: July 2020

This paper explores and determines specific features of the harmonic language of Petar Konjović (1883–1970) in relation to the music-dramatic portraits of Hadži Toma and Alil – the two main characters in the composer’s most significant opera "Koštana" (1931), inspired by the playof Borisav Stanković (1876–1927). Viewed through a starting hypothesis by which harmony is one of the most important elements of Konjović’s modernity, this paper primarily aims to precisely identify the harmonic potentials of the composer’s „speach“ in the songs of the afore mentioned protagonists. The very music-dramatic function of the chosen songs has been an inspiring subject of this research. Another, non the less atractive subject was enlightening Konjović’s relation towards folklore, with the special focus in his approach towards harmonizing folk songs. Special attention was payed to aspects of Konjovic’s relation towards the heritage of Mokranjac. Results of the harmonic analysis have proven that the vertical dimension of the chosen songs show a skillful refraction of tonal and modal space with specific folklore scales and formulas which, along with the chordal diversity, points to an individual harmonic system and music thought of Petar Konjović as an authentic representative of the „national orientation“ in the developmental period of Serbian music between the two World wars, within its – at that time – Yugoslav and European frames.
Análisis cualitativo de modelos de negocio para el emprendimiento social
Authors: Espínola Verdín Vicente , Torres González Luis Adolfo 
Published: July 2020

Objetivo: identificar las diferencias conceptuales, características y modelos de negocio que aplican los emprendimientos sociales y las empresas sociales mediante la investigación y análisis de los principales autores en los últimos 20 años con la finalidad de establecer aportaciones para el desarrollo de estrategias para su impulso.Diseño metodológico: investigación documental, análisis, discusión y comparación cualitativa.Resultados: el estudio del emprendimiento social se enmarca en dos escuelas de pensamiento, de la empresa social y de la innovación social. Se identifican diferentes modelos de negocio para éstos y se analizan cuáles aplican para cada escuela de pensamiento.Limitaciones de la investigación: el estudio del emprendimiento social y la empresa social en México se encuentra limitado a propuestas de cooperativismo y a estudio de casos individuales. No se encontró un enfoque que se diferencie en México o Latinoamérica.Hallazgos: el elemento en común del emprendimiento y la empresa social se encuentra en su misión social. Sus modelos de negocio se diferencian en cómo el emprendimiento se relaciona con sus beneficiarios y cómo se relaciona con el mercado. El emprendimiento social presenta mayor flexibilidad para la aplicación de modelos de negocio comparado con la empresa social.