bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep Entity Matching
Authors: Li Yuliang , Li Jinfeng , Suhara Yoshihiko , Wang Jin , Hirota Wataru , Tan Wang-Chiew 
Published: January 2021

Entity matching refers to the task of determining whether two different representations refer to the same real-world entity. It continues to be a prevalent problem for many organizations where data resides in different sources and duplicates the need to be identified and managed. The term “entity matching” also loosely refers to the broader problem of determining whether two heterogeneous representations ofdifferent entitiesshould be associated together. This problem has an even wider scope of applications, from determining the subsidiaries of companies to matching jobs to job seekers, which has impactful consequences.In this article, we first report our recent system DITTO, which is an example of a modern entity matching system based on pretrained language models. Then we summarize recent solutions in applying deep learning and pre-trained language models for solving the entity matching task. Finally, we discuss research directions beyond entity matching, including the promise of synergistically integrating blocking and entity matching steps together, the need to examine methods to alleviate steep training data requirements that are typical of deep learning or pre-trained language models, and the importance of generalizing entity matching solutions to handle the broader entity matching problem, which leads to an even more pressing need to explain matching outcomes.
T Cells Expanded from PD-1+ Peripheral Blood Lymphocytes Share More Clones with Paired Tumor-Infiltrating Lymphocytes
Authors: Li Tiepeng , Zhao Lingdi , Yang Yonghao , Wang Yao , Zhang Yong , Guo Jindong , Chen Guangyu , Qin Peng , Xu Benling , Ma Baozhen , Zhang Fang , Shang Yiman , Li Qingjun , Zhang Kai , Yuan Dongfeng , Feng Chaojie , Ma Yan , Liu Zhiyong , Tian Zhichao , Li Hongle , Wang Shengdian , Gao Quanli 
Published: January 2021

Abstract

Both tumor-infiltrating lymphocytes (TIL) and PD-1+ peripheral blood lymphocytes (PBL) are enriched for tumor-reactive clones recognizing known and unknown tumor antigens. However, the relationship between the T-cell receptor-β (TCRβ) repertoires of the TILs and T cells expanded from paired PD-1+ PBLs, and whether T cells expanded from PD-1+ PBLs can be used to treat patients with cancer as TIL substitutes remain unclear. Here, we established a highly efficient protocol to prepare polyclonal T cells from PD-1+ PBLs. A functional T-cell assay and tetramer staining revealed that cells from PD-1+ PBLs were relatively enriched for tumor-reactive T cells. Furthermore, deep TCRβ sequencing data revealed that an average of 11.29% (1.32%–29.06%; P = 0.015; n = 8) tumor-resident clonotypes were found in T cells expanded from paired PD-1+ PBLs, and the mean accumulated frequency of TIL clones found in T cells expanded from PD-1+ PBLs was 35.11% (7.23%–78.02%; P = 0.017; n = 8). Moreover, treatment of four patients, who failed multiline therapy and developed acquired resistance to anti-PD-1, with autologous T cells expanded from PD-1+ PBLs combined with anti-PD-1 antibody elicited objective responses from three of them. These results indicate that T cells expanded from PD-1+ PBLs share more clones with paired TILs and could be used to treat patients with cancer as TIL substitutes.

Significance:
This study harnesses the tumor reactivity of PD-1+ PBLs, developing a method to expand T cells from these clones as a potential therapeutic strategy and TIL substitute in patients with cancer.
See related commentary by Ladle, p. 1940
A novel branch current flow-based construction of microgrids
Authors: Sivakumar Kavitha , R Jayashree , Danasagaran Karthikeyan 
Published: January 2021

<span>An efficient procedure for defining the boundaries of microgrids in smart distribution systems during distributed generation expansion planning becomes an important consideration in constructing smart grids. A novel approach named "Modified Reverse Current Flow Method" is proposed in this paper to split a large radial distribution system into a required number of self-adequate microgrids. This cluster of microgrids will be capable of utilizing maximum power output of the distributed renewable energy generators and will act as highly reliable zones, during both islanded and grid-connected modes. This method is based on the trend reversal of the flow of current in the various parts of the circuit. This paper uses the practical machine operating curves of the distributed generators to calculate their reactive power output. For the considered distribution system, the proposed method is applied to find the optimal point of operation and the boundaries of microgrids. To bring out the superiority of this novel method, the improvement in reliability indices and economic savings of this method are compared with the results obtained using a similar method available in the literature. This method has several notable merits, namely, increased accuracy in the calculation of annual energy losses and the voltage profile. </span>
Real time model of a lock gate system upon fingerprint with microcontroller
Authors: Jasem Mahammad Maath , Al Mashhadany Yousif , Mohammad Eyada Abdulkader 
Published: January 2021

<span>Safety is one of the most important things that we are keen to provide all aspects of our lives. Keyless lock gate with fingerprint access has many advantages over traditional systems such as passwords. Therefore, fingerprint identification represents the main part, which require that system is cheap, practical, easy to use and allows fast and securely. This paper discusses the design and implementation with real time model of a practical lock gate system for the achievement of high security by using fingerprint purification to control the mechanism of opening doors in banks, warehouses, laboratories and places of interest. In this paper, the microcontroller technology in the Ardonio board was used with an optical sensor to take the fingerprint, convert it into digital data, and insert it into a definition window to unify all input data and store it for use when compared to the system experience. After obtaining the result of the comparison, the appropriate commands are prepared for operating the servo of the lock mechanism for the doors used. In the testing of the system, the results are very accurate. The system also has other advantages such as small size and low power required for operation and ease of use. </span>
Working memory enhancement during early childhood based on the utilization of interactive gesture game-based learning technique
Authors: Lakshmi D. , Ponnusamy Ponnusamy 
Published: January 2021

<p>The use of human computer interaction is considered to be the most culturally and socially meritorious for the learning and playing activities of children. In this paper, a human interaction recognition system (HIRS) that includes gesture game-based learning is investigated for identifying its suitability and applicability in stimulation of working memory and primitive mathematical skills among the children in the early childhood period that ranges from 5 and 8 years. In the proposed human interaction recognition system, the hand gestures are facilitated by the user for the objective of controlling the computer system based on the information extracted from the user gestures.This proposed research was implemented in three phases using a quasi-experimental design that in turn incorporates pre-test and post-test for investigating the behavior of experimental and control group considered from the respondents. In the first phase, the initial evaluation of the learner’s skill is achieved. The second phase used the developed technology in order to identify diversified parameters in different dimensions that contribute towards the assessment of working memory and primitive mathematical capabilities. Finally, the third phase is responsible for actual evaluation. In the phases of evaluation, four working memory tests such as forward Corsi Blocking-Tapping test, backward Corsi Blocking-Tapping test, Forward Digit Span test and backwardDigit Span test was conducted. In addition, the evaluation was also conducted for assessing primitive mathematical skill of children using TEDI-MATH. The results confirmed that Gesture Interactive Game-Based Learning (GIGL) used by the children exhibited a predominant improvement in the working memory and primitive mathematical skills on par with their usual school activities.</p>
Biting the Bullet
Authors: Turnbull Stephen 
Published: January 2021

Abstract
The deployment and use of European harquebuses following their introduction to Japan in 1543 is conventionally regarded as having followed a straightforward path of enthusiastic adoption, wherein the Japanese adapted and improved the revolutionary new weapons. This paper demonstrates that the procedure was instead both haphazard and idiosyncratic. In many cases firearms were tried by Japan’s rival daimyo (lords) and then either neglected or used ineffectively, a hit-and-miss approach that can even be identified in the person of Oda Nobunaga, the man who is usually credited with Japan’s military revolution. The situation is however complicated by the nomenclature used for the guns themselves, the projectiles, and even the nature of the wounds they caused. As for their impact, until the battle of Nagashino in 1575 all the actions involving firearms took place at defended positions with almost no mention of guns being used during open battles.
Dynamic genome-wide association analysis and identification of candidate genes involved in anaerobic germination tolerance in rice
Authors: Su Ling , Yang Jing , Li Dandan , Peng Ziai , Xia Aoyun , Yang Meng , Luo Lixin , Huang Cuihong , Wang Jiafeng , Wang Hui , Chen Zhiqiang , Guo Tao 
Published: January 2021

Abstract
Background
In Asian rice production, an increasing number of countries now choose the direct seeding mode because of rising costs, labour shortages and water shortages. The ability of rice seeds to undergo anaerobic germination (AG) plays an important role in the success of direct seeding.

Results
In this study, we used 2,123,725 single nucleotide polymorphism (SNP) markers based on resequencing to conduct a dynamic genome-wide association study (GWAS) of coleoptile length (CL) and coleoptile diameter (CD) in 209 natural rice populations. A total of 26 SNP loci were detected in these two phenotypes, of which 5 overlapped with previously reported loci (S1_ 39674301, S6_ 20797781, S7_ 18722403, S8_ 9946213, S11_ 19165397), and two sites were detected repeatedly at different time points (S3_ 24689629 and S5_ 27918754). We suggest that these 7 loci (−log10 (P) value > 7.3271) are the key sites that affect AG tolerance. To screen the candidate genes more effectively, we sequenced the transcriptome of the flooding-tolerant variety R151 in six key stages, including anaerobic (AN) and the oxygen conversion point (AN-A), and obtained high-quality differential expression profiles. Four reliable candidate genes were identified: Os01g0911700 (OsVP1), Os05g0560900 (OsGA2ox8), Os05g0562200 (OsDi19–1) and Os06g0548200. Then qRT-PCR and LC-MS/ MS targeting metabolite detection technology were used to further verify that the up-regulated expression of these four candidate genes was closely related to AG.

Conclusion
The four novel candidate genes were associated with gibberellin (GA) and abscisic acid (ABA) regulation and cell wall metabolism under oxygen-deficiency conditions and promoted coleoptile elongation while avoiding adverse effects, allowing the coleoptile to obtain oxygen, escape the low-oxygen environment and germinate rapidly. The results of this study improve our understanding of the genetic basis of AG in rice seeds, which is conducive to the selection of flooding-tolerant varieties suitable for direct seeding.
Sturge-Weber syndrome coexisting with polydactyly: a case report
Authors: Wang Hongxi , Dong Nana , Tan Li , Huang Chukai 
Published: January 2021

AbstractBackgroundSturge-Weber syndrome (SWS) is a sporadic congenital disorder, characterized by unilateral facial nevus flammeus associated with ipsilateral glaucoma, choroidal angioma and leptomeningeal hemangiomas. SWS can comorbid with other disorders in some patients, however, there has been no prior described case of SWS and polydactyly occurring in the same patient.Case presentationA 15-year-old girl with diagnosis of SWS presented to our hospital. She had bilateral glaucoma and extensive port-wine stains distributing in bilateral faces, left neck and left upper limb. Meanwhile, the patient was noted to demonstrate the superfluous digit attaching on the left thumb and was diagnosed as polydactyly. Trabeculectomy, with intraoperative application of mitomycin C and postoperative subconjunctival injections of 5-fluorouracil, was successful in controlling the intraocular pressure in both eyes.ConclusionsWe report a case with bilateral SWS coexisting with unilateral polydactyly, which, to our knowledge, has not been recognized previously and adds further evidence to the existing literature. In view of the rare concurrence of SWS and polydactyly, the etiology is unclear and further investigation is required to explore the underlying pathogenesis.
A longitudinal analysis of the progression from normal blood pressure to stage 2 hypertension: A 12-year Korean cohort
Authors: Yu Eun Sun , Hong Kwan , Chun Byung Chul 
Published: January 2021

Abstract
Background
The study aimed to estimate the incidence of and period of progression to stage 2 hypertension from normal blood pressure.

Methods
We selected a total of 21,172 normotensive individuals between 2003 and 2004 from the National Health Insurance Service-Health Screening and followed them up until 2015. The criteria for blood pressure were based on the American College of Cardiology/American Heart Association 2017 guideline (normal BP: SBP < 120 and DBP < 80 mmHg, elevated BP: SBP 120–129 and DBP < 80 mmHg, stage 1 hypertension: SBP 130–139 or DBP 80–89 mmHg, stage 2 hypertension: SBP ≥140 or DBP ≥ 90 mmHg). We classified the participants into four courses (Course A: normal BP → elevated BP → stage 1 hypertension→ stage 2 hypertension, Course B: normal BP → elevated BP → stage 2 hypertension, Course C: normal BP → stage 1 hypertension → stage 2 hypertension, Course D: normal BP → stage 2 hypertension) according to their progression from normal blood pressure to stage 2 hypertension.

Results
During the median 12.23 years of follow-up period, 52.8% (n= 11,168) and 23.6% (n=5004) of the participants had stage 1 and stage 2 hypertension, respectively. In particular, over 60 years old had a 2.8-fold higher incidence of stage 2 hypertension than 40–49 years old. After the follow-up period, 77.5% (n=3879) of participants with stage 2 hypertension were found to be course C (n= 2378) and D (n=1501). After the follow-up period, 77.5% (n=3879) of participants with stage 2 hypertension were found to be course C (n= 2378) and D (n=1501). The mean years of progression from normal blood pressure to stage 2 hypertension were 8.7±2.6 years (course A), 6.1±2.9 years (course B), 7.5±2.8 years (course C) and 3.2±2.0 years, respectively.

Conclusions
This study found that the incidence of hypertension is associated with the progression at each stage. We suggest that the strategies necessary to prevent progression to stage 2 hypertension need to be set differently for each target course.
An infected aneurysm of the vertebral artery following cervical pyogenic spondylitis: a case report and literature review
Authors: Furukawa Takahiro , Masuda Keisuke , Shigematsu Hideki , Tanaka Masato , Okuda Akinori , Kawasaki Sachiko , Suga Yuma , Yamamoto Yusuke , Tanaka Yasuhito 
Published: January 2021

Abstract
Background
An important complication of pyogenic spondylitis is aneurysms in the adjacent arteries. There are reports of abdominal aortic or iliac aneurysms, but there are few reports describing infected aneurysms of the vertebral artery. Furthermore, there are no reports describing infected aneurysms of the vertebral arteries following cervical pyogenic spondylitis. We report a rare case of an infected aneurysm of the vertebral artery as a complication of cervical pyogenic spondylitis, which was successfully treated by endovascular treatment.

Case presentation
Cervical magnetic resonance imaging (MRI) of a 59-year-old man who complained of severe neck pain showed pyogenic spondylitis. Although he was treated extensively by antibiotic therapy, his neck pain did not improve. Follow-up MRI showed the presence of a cyst, which was initially considered an abscess, and therefore, treatment initially included guided tapping and suction under ultrasonography. However, under ultrasonographic examination an aneurysm was detected. The contrast-enhanced computed tomography (CT) scan showed an aneurysm of the vertebral artery. Following endovascular treatment (parent artery occlusion: PAO), the patient’s neck pain disappeared completely.

Conclusion
Although there are several reports of infected aneurysms of the vertebral arteries, this is the first report describing an infected aneurysm of the vertebral artery as a result of cervical pyogenic spondylitis.
Whenever a paraspinal cyst exist at the site of infection, we recommend that clinicians use not only X-ray, conventional CT, and MRI to examine the cyst, but ultrasonography and contrast-enhanced CT as well because of the possibility of an aneurysms in neighboring blood vessels. It is necessary to evaluate the morphology of the aneurysm to determine the treatment required.
Menstrual, reproductive and hormonal factors and thyroid cancer: a hospital-based case–control study in China
Authors: Wang Meng , Gong Wei-Wei , He Qing-Fang , Hu Ru-Ying , Yu Min 
Published: January 2021

Abstract
Background
There have been considerable studies on the effects of reproductive factors on thyroid cancer risk, while findings are inconsistent. In this analysis, we aimed to investigate the associations between menstrual, reproductive and hormonal factors with thyroid cancer occurrence in a population of Chinese women.

Methods
Using data from a 1:1 matched case–control study performed between 2015 and 2017 in Zhejiang Province of China, a second analysis of 2261 pairs of female subjects was conducted. The possible effects for thyroid cancer were evaluated in logistic regression models by odds ratios (ORs) with 95% confidence intervals (CIs).

Results
Later age at first pregnancy (for > 25 vs. ≦ 20 years, OR: 0.47, 95% CI 0.23–0.96) and longer duration of breast feeding (for 6–12 vs. ≦ 6 months, OR: 0.49, 95% CI 0.24–0.98) were significantly associated with decreased occurrence of thyroid cancer, while no trend was observed. Stratified by age at enrollment, only the association with duration of breast feeding remained significant, but limited to younger women (≦ 50 years).

Conclusions
Our results suggested that women with later age at first pregnancy or longer breast feeding duration were less likely to have thyroid cancer. These findings supported an influence role of reproductive factors in thyroid cancer risk.
Optogenetic inhibition of medial entorhinal cortex inputs to the hippocampus during a short period of time right after learning disrupts contextual fear memory formation
Authors: Kang Min Soo , Han Jin-Hee 
Published: January 2021

AbstractFormation of temporal association memory and context-specific fear memory is thought to require medial entorhinal cortex (MEC) inputs to the hippocampus during learning events. However, whether the MEC inputs are also involved in memory formation during a post-learning period has not been directly tested yet. To examine this possibility, we optogenetically inhibited axons and terminals originating from bilateral dorsal MEC excitatory neurons in the dorsal hippocampus for 5 min right after contextual fear conditioning (CFC). Mice expressing eNpHR3.0 exhibited significantly less freezing compared to control mice expressing EGFP alone during retrieval test in the conditioned context 1 day after learning. In contrast, the same optogenetic inhibition of MEC inputs performed 30 min before retrieval test did not affect freezing during retrieval test, excluding the possibility of non-specific deleterious effect of optical inhibition on retrieval process. These results support that contextual fear memory formation requires MEC inputs to the hippocampus during a post-learning period.
NK cell-based cancer immunotherapy: from basic biology to clinical development
Authors: Liu Sizhe , Galat Vasiliy , Galat4 Yekaterina , Lee Yoo Kyung Annie , Wainwright Derek , Wu Jennifer 
Published: January 2021

AbstractNatural killer (NK) cell is a specialized immune effector cell type that plays a critical role in immune activation against abnormal cells. Different from events required for T cell activation, NK cell activation is governed by the interaction of NK receptors with target cells, independent of antigen processing and presentation. Due to relatively unsophisticated cues for activation, NK cell has gained significant attention in the field of cancer immunotherapy. Many efforts are emerging for developing and engineering NK cell-based cancer immunotherapy. In this review, we provide our current understandings of NK cell biology, ongoing pre-clinical and clinical development of NK cell-based therapies and discuss the progress, challenges, and future perspectives.
Targeting oncogenic Notch signaling with SERCA inhibitors
Authors: Pagliaro Luca , Marchesini Matteo , Roti Giovanni 
Published: January 2021

AbstractP-type ATPase inhibitors are among the most successful and widely prescribed therapeutics in modern pharmacology. Clinical transition has been safely achieved for H+/K+ATPase inhibitors such as omeprazole and Na+/K+-ATPase inhibitors like digoxin. However, this is more challenging for Ca2+-ATPase modulators due to the physiological role of Ca2+in cardiac dynamics. Over the past two decades, sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) modulators have been studied as potential chemotherapy agents because of their Ca2+-mediated pan-cancer lethal effects. Instead, recent evidence suggests that SERCA inhibition suppresses oncogenic Notch1 signaling emerging as an alternative to γ-secretase modulators that showed limited clinical activity due to severe side effects. In this review, we focus on how SERCA inhibitors alter Notch1 signaling and show that Notch on-target-mediated antileukemia properties of these molecules can be achieved without causing overt Ca2+cellular overload.
Maintenance therapy in acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation
Authors: Xuan Li , Liu Qifa 
Published: January 2021

AbstractRelapse remains the main cause of treatment failure in acute myeloid leukemia (AML) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Emerging evidence has demonstrated that AML patients might benefit from maintenance therapy post-transplantation, especially for high-risk AML patients. In this mini-review, we will summarize targeted drugs, such as hypomethylating agents, FLT3 inhibitors and isocitrate dehydrogenase inhibitors, as maintenance therapy post-transplantation in AML patients undergoing allo-HSCT.