bluuebunny/crossref_metadata_2025_split huggingface dataset:
IgG4‐related disease in the differential diagnosis of lung nodules
Authors: Ishikawa Hiroki , Uruga Hironori , Fujii Takeshi , Kurosaki Atsuko , Morokawa Nasa , Takaya Hisashi 
Published: March 2020

AbstractIgG4‐related disease is an evolving entity of immune‐mediated origin. We report a case of IgG4‐related disease mimicking lung cancer with pleural dissemination. A 76‐year‐old male non‐smoker was admitted to our hospital because of chest X‐ray abnormality. Chest computed tomography scan showed a lung nodule measuring 26 × 14 mm with tiny nodules on the adjacent pleural surface. Wedge resection by video‐assisted thoracoscopic surgery (VATS) was performed to aid diagnosis. Pathological findings of the nodule consisted of lymphoid follicular hyperplasia with lymphoplasmacytic infiltrate, fibrosis, and obstructive vasculitis. Focal and scattered thickening of the pleura with lymphoplasmacytic infiltrate was also observed. The IgG4/IgG ratio in the most prominent area exceeded 80%. Thus, we made a diagnosis of IgG4‐related lung and pleural disease. To our knowledge, there has been no report of IgG4‐related lung disease mimicking lung cancer with pleural dissemination.
Wehr Horkheim am Neckar: Grundinstandsetzung
Authors: Freitag Andreas , Englert Rüdiger , Schäfers Matthias 
Published: March 2020

AbstractDas Wehr Horkheim befindet sich am Neckar und bildet gemeinsam mit der Schleuse, dem Kraftwerk und einem Hochwassersperrtor die stromaufwärts nächste Staustufe nach Heilbronn. Das Wehr selbst liegt am oberen Ende im Horkheimer Altneckar und wurde in den Jahren 1927–1929 errichtet.Im Jahr 2008 wurde durch die WSV (Wasserstraßen‐ und Schifffahrtsverwaltung des Bundes) auf Grundlage des altersgemäßen Bauwerkszustands beschlossen, eine Grundinstandsetzung des Wehrs vorzunehmen und dem Amt für Neckarausbau Heidelberg (ANH) die Planungshoheit bezüglich dieser Maßnahme übertragen.Das ANH hat hierzu im Jahr 2008 die Planungsgemeinschaft aus den beiden Ingenieurbüros IRS Stahlwasserbau Consulting AG (Würzburg) und Weber‐Ingenieure GmbH (Heilbronn) mit der Planung der Grundinstandsetzung beauftragt.Die Planung erfolgte im Wesentlichen gemäß der DIN 19704 (Stahlwasserbau), DIN 18800 Teil 1‐3 (Stahlbau, damals gültige Norm) und für die Fischbauchklappe nach EN 1993‐1‐1 für den Nachweis auf Ermüdung.
Efficient Construction of a Chemical Reaction Network Guided By a Monte Carlo Tree Search
Authors: Lee Kyunghoon , Woo Kim Jin , Youn Kim Woo 
Published: March 2020

AbstractChemical reaction networks are essential for the complete elucidation of chemical reaction mechanisms. Graph‐theoretic methods combined with quantum calculations are known to be an efficient approach with broad applicability for constructing reaction networks. However, this method entails high computational cost due to quantum calculations on chemically irrelevant intermediates coming from the exploration of a large scale chemical space. To remedy this problem, we propose to apply the Monte Carlo tree search algorithm to those graph‐theoretic methods. We have combined it with ACE‐Reaction, our in‐house graph‐theoretic method, and demonstrated its performance on five organic reactions. The result shows that the computational cost for quantum calculations has been reduced by up to 75 % from that of the original ACE‐Reaction. Furthermore, cost reduction became more efficient for more complex reactions.
Ontology‐driven perspective of CFRaaS
Authors: Kebande Victor R. , Karie Nickson M. , Ikuesan Richard A. , Venter Hein S. 
Published: March 2020

AbstractA Cloud Forensic Readiness as a Service (CFRaaS) model allows an environment to preemptively accumulate relevant potential digital evidence (PDE) which may be needed during a post‐event response process. The benefit of applying a CFRaaS model in a cloud environment, is that, it is designed to prevent the modification/tampering of the cloud architectures or the infrastructure during the reactive process, which if it could, may end up having far‐reaching implications. The authors of this article present the reactive process as a very costly exercise when the infrastructure must be reprogrammed every time the process is conducted. This may hamper successful investigation from the forensic experts and law enforcement agencies perspectives. The CFRaaS model, in its current state, has not been presented in a way that can help to classify or visualize the different types of potential evidence in all the cloud deployable models, and this may limit the expectations of what or how the required PDE may be collected. To address this problem, the article presents the CFRaaS from a holistic ontology‐driven perspective, which allows the forensic experts to be able to apply the CFRaaS based on its simplicity of the concepts, relationship or semantics between different form of potential evidence, as well as how the security of a digital environment being investigated could be upheld. The CFRaaS in this context follows a fundamental ontology engineering approach that is based on the classical Resource Description Framework. The proposed ontology‐driven approach to CFRaaS is, therefore, a knowledge‐base that uses layer‐dependencies, which could be an essential toolkit for digital forensic examiners and other stakeholders in cloud‐security. The implementation of this approach could further provide a platform to develop other knowledge base components for cloud forensics and security.This article is categorized under:
Digital and Multimedia Science > Cloud Forensics
Digital and Multimedia Science > Cyber Threat Intelligence
Digital and Multimedia Science > Multimedia Forensics
A supersymmetric theory of baryogenesis and sterile sneutrino dark matter from B mesons
Authors: Alonso-Álvarez Gonzalo , Elor Gilly , Nelson Ann E. , Xiao Huangyu 
Published: March 2020

Abstract
Low-scale baryogenesis and dark matter generation can occur via the production of neutral B mesons at MeV temperatures in the early Universe, which undergo CP-violating oscillations and subsequently decay into a dark sector. In this work, we discuss the consequences of realizing this mechanism in a supersymmetric model with an unbroken U(1)R symmetry which is identified with baryon number. B mesons decay into a dark sector through a baryon number conserving operator mediated by TeV scale squarks and a GeV scale Dirac bino. The dark sector particles can be identified with sterile neutrinos and their superpartners in a type-I seesaw framework for neutrino masses. The sterile sneutrinos are sufficiently long lived and constitute the dark matter. The produced matter-antimatter asymmetry is directly related to observables measurable at B factories and hadron colliders, the most relevant of which are the semileptonic-leptonic asymmetries in neutral B meson systems and the inclusive branching fraction of B mesons into hadrons and missing energy. We discuss model independent constraints on these experimental observables before quoting predictions made in the supersymmetric context. Constraints from astrophysics, neutrino physics and flavor observables are studied, as are potential LHC signals with a focus on novel long lived particle searches which are directly linked to properties of the dark sector.
Comparison of EMI effects on different current mirror structures using a post-processing framework
Authors: Zupan Dominik , Deutschmann Bernd 
Published: March 2020

AbstractIn this paper the use of a simulation framework for comparing the effects of electromagnetic interference (EMI) on different current mirror structures is demonstrated. This is done with the help of an existing tool that is extended by specific, newly developed Python® scripts. The Cadence Design System and Spectre are used as simulation environment. The resulting outputs obtained by DC and transient simulations serve as an input for the next post-processing steps. The investigated current mirror topologies are well-described in literature and are already analyzed with respect to their EMI robustness. This paper focuses on simplifying the comparison of these structures and reducing the need of mathematical derivations. The script results are displayed directly in the schematic by using a heatmap and annotations for voltage nodes and current terminals. Mainly, two analyses are performed, whereas one part deals with EMI-induced DC offset shifts and the other part deals with the propagation of disturbance frequencies to the output current. Finally, the analytic results are compared with the graphical ones in order to check the feasibility of using the presented framework and the newly developed scripts and procedures.
Better outcomes after mini-subvastus approach for primary total knee arthroplasty: a Bayesian network meta-analysis
Authors: Migliorini Filippo , Aretini Paolo , Driessen Arne , El Mansy Yasser , Quack Valentin , Tingart Markus , Eschweiler Jörg 
Published: March 2020

Abstract
Introduction
Alternatives to the classical medial parapatellar (MPP) approach for total knee arthroplasty (TKA) include the mini-medial parapatellar (MMPP), mini-subvastus (MSV), mini-midvastus (MMV) and quadriceps-sparing (QS) approaches. The best approach has been not fully clarified. The purpose of the present study was to conduct a Bayesian network meta-analysis comparing these approaches.

Materials and methods
The present analysis was carried out according to the PRISMA extension statement for reporting systematic reviews incorporating network meta-analyses of healthcare interventions. The databases search was performed in October 2019. All clinical trials comparing two or more approaches for primary TKA were considered for inclusion. The baseline comparability was evaluated through the analysis of variance (ANOVA) test. The statistical analysis was performed through the STATA software/MP. A Bayesian hierarchical random-effects model analysis was adopted in all the comparisons.

Results
Data from 52 articles (4533 patients) were collected. The mean follow-up was 20.38 months. With regard to diagnosis, gender, age and BMI, adequate baseline comparability was detected. The MSV approach ranked better concerning clinical scores (the lowest visual analogic scale, the higher KSS and KSFS) and functional outcomes (the shortest straight leg raise, the greatest degree of flexion and range of motion). Concerning perioperative data, the MSV evidenced the shortest hospital stay, while the MPP the shortest surgical duration and lowest estimated blood loss.

Conclusion
According to the main findings of the present study, the mini-subvastus approach for total knee arthroplasty demonstrated superior overall compared to the other approaches. Orthopaedic surgeons should consider this approach in the light of the evidence and limitations of this Bayesian network meta-analysis.
Effects of nutraceutical intervention on serum proteins in aged rats
Authors: Portis Samantha M. , Chaput Dale , Burroughs Beau , Hudson Charles , Sanberg Paul R. , Bickford Paula C. 
Published: March 2020

AbstractAging is associated with many pathophysiological changes that could lead to the onset of degenerative disease. Some of the physiological changes that occur with aging include increased inflammation and decreased stem cell proliferation, leading to decreased capacity for tissue regeneration and loss of function. In previous studies, we and others have found nutraceutical intervention to ameliorate some of the deleterious effects associated with aging. In particular, we have previously shown that NT-020, a supplement composed of a proprietary blend of blueberries, green tea, vitamin D3, and carnosine, is able to rescue age-related cognitive deficits, impaired neurogenesis, and inflammation in rats. We have also previously demonstrated that stem cells cultured with old serum showed decreased proliferation; however, when stem cells were cultured in serum from old rats given a diet supplemented with NT-020, proliferation did not differ from that of cells cultured with serum from young rats. While it is clear that NT-020 is exerting a therapeutic, anti-aging effect, the mechanisms of action were yet to be fully elucidated.To that end, in the present study, we conducted a bioinformatics experiment to examine the rat proteome of serum from young and old control rats and young and old rats given a diet supplemented with NT-020. Serum from old rats showed an increase in some inflammatory and pro-aging factors while serum from old rats given a diet supplemented with NT-020 showed an increase in some anti-aging factors, most notably proteins associated with the complement system and autophagy. A number of immune functions that increase with age were shown to be downregulated with NT-020 treatment.
Development of a novel TIG hot-wire process for wire and arc additive manufacturing
Authors: Spaniol E. , Ungethüm T. , Trautmann M. , Andrusch K. , Hertel M. , Füssel U. 
Published: March 2020

AbstractThe presented work deals with the development of a novel TIG hot-wire process for the additive manufacturing of metallic components, which, in contrast to previous arc processes, enables a significant increase in melting performance with simultaneously reduced heat input. This is achieved by means of an upstream resistance heating of the wire between two contact points within the hot wire feeding system. The torch, hot wire feeder and gas nozzle are designed in such a way that a constant bead geometry can be guaranteed regardless of the machining direction. On the one hand, this can improve the dimensional accuracy; on the other hand, an increase in productivity is achieved through a significant reduction of process times. Essential parts of the work include the simulation-supported development of the processing system, the design and implementation of an innovative process control system and the testing of the new technology.
Noise Reduction in Coherence Scanning Interferometry for Surface Topography Measurement
Authors: Gomez Carlos , Su Rong , de Groot Peter , Leach Richard 
Published: March 2020

AbstractCoherence scanning interferometry is one of the most accurate surface measuring technologies, and it is increasingly applied to challenging surface structures, such as additive manufactured parts and transparent films, directly in environments that resemble production areas more than metrology labs. Environmental disturbances may further compromise measurement accuracy. Data acquisition strategies to reduce measurement noise in coherence scanning interferometry include averaging a sequence of repeated topography measurements or increasing the sampling frequency of the fringe signal during a single data acquisition—sometimes referred to as oversampling. In this paper, we improve the understanding of the mechanisms of the two noise reduction methods and compare their effects on surface topography measurement in the presence of environment-induced vibration. The results provide guidance for good practice in the reduction of uncertainty in surface measurement for a wide range of applications.
Homogenization of the 1D Peri-static/dynamic Bar with Constant Micromodulus
Authors: Eriksson Kjell , Stenström Christer 
Published: March 2020

AbstractBecause of the nonlocal interparticle forces inherent in peridynamics, surface, boundary, and end effects appear in 3D, 2D and 1D body problems, respectively. In certain situations, the effect is seen as a disturbance, and various efforts, mostly centering on 2D and 1D problems, have been made to reduce it. A simple method has been derived to remove the end effects in a 1D body by homogenizing the body. When a certain body type, common in practice, is homogenized, its linear elastic behavior, independent of the interparticle force range and with a finite number of material points, in the limit infinite, is identical to that of a corresponding classical continuum mechanics body.
Hyper-polyploid embryos survive after implantation in mice
Authors: Imai Hiroyuki , Iwamori Tokuko , Kusakabe Ken Takeshi , Kiso Yasuo , Ono Etsuro , Kano Kiyoshi 
Published: March 2020

SummaryPolyploids generated by natural whole genome duplication have served as a dynamic force in vertebrate evolution. As evidence for evolution, polyploid organisms exist generally, however there have been no reports of polyploid organisms in mammals. In mice, polyploid embryos under normal culture conditions normally develop to the blastocyst stage. Nevertheless, most tetraploid embryos degenerate after implantation, indicating that whole genome duplication produces harmful effects on normal development in mice. Most previous research on polyploidy has mainly focused on tetraploid embryos. Analysis of various ploidy outcomes is important to comprehend the effects of polyploidization on embryo development. The purpose of this present study was to discover the extent of the polyploidization effect on implantation and development in post-implantation embryos. This paper describes for the first time an octaploid embryo implanted in mice despite hyper-polyploidization, and indicates that these mammalian embryos have the ability to implant, and even develop, despite the harmfulness of extreme whole genome duplication.
An Effective Method to Extract Overtones of Surface Wave From Array Seismic Records of Earthquake Events
Authors: Li Zhengbo , Chen Xiaofei 
Published: March 2020

AbstractSurface wave dispersion curves are extensively used to map the lithospheric shear‐wave velocity structures. However, traditional methods have difficulty extracting overtone dispersion curves from both ambient noise and seismic event data. Recently, Wang et al. (2019, https://doi.org/10.1029/2018JB016595) proposed a new array‐based method, the frequency‐Bessel transform (F‐J) method, to extract high frequency overtones from ambient noise data. However, because the Green's functions of earthquakes are complex, the F‐J method cannot be directly applied to extract overtones from earthquake event data. In this paper, we analyze the differences between ambient noise and earthquake event data and verify that the F‐J method can be efficiently applied to event data by controlling the azimuthal range and adopting time windows. For the F‐J method using earthquake records, the time windows calculated by group velocity intervals can improve the overtone extraction efficiency. We named this application of the F‐J method with time windows using event data the multiwindow F‐J (MWFJ) method to distinguish the two techniques. Further verifications were performed using real data from three earthquakes recorded by the U.S. Transportable Array. Compared to traditional methods for extracting overtones from earthquakes, the MWFJ method can effectively extract higher‐frequency (0.02–0.4 Hz, for the data used in this work) and higher‐resolution overtones from event data. Moreover, the overtones extracted from earthquakes are more sensitive to deeper structures than those extracted from ambient noise. The complementarity of the F‐J and MWFJ methods for the extraction of overtones indicates that better imaging results may be obtained by combining these two methods.
Vertical Coupling Between the Cloud‐Level Atmosphere and the Thermosphere of Venus Inferred From the Simultaneous Observations by Hisaki and Akatsuki
Authors: Nara Y. , Imamura T. , Masunaga K. , Lee Y. J. , Terada N. , Yoshioka K. , Yamazaki A. , Seki K. , Yoshikawa I. , Yamada M. , Watanabe S. 
Published: March 2020

AbstractThe vertical coupling between the cloud‐level atmosphere and the thermosphere of Venus was investigated using 365 nm images obtained by the Ultraviolet Imager on board Akatsuki and oxygen atom 135.6 nm dayglow intensities obtained by the Extreme Ultraviolet Spectroscope for Exospheric Dynamics on board the space telescope Hisaki. Simultaneous observations revealed a common periodicity of ~3.6 Earth days in the cloud‐tracked velocity, the cloud brightness, and the airglow intensity. The oscillation at the cloud level is attributed to a planetary‐scale Kelvin wave. A one‐dimensional linear wave model showed that the Kelvin wave cannot propagate from the cloud level to the thermosphere because of radiative damping. The modeling also revealed that a small‐scale gravity waves having wavelengths of <1,000 km can reach the thermosphere on the dawnside and that they are strongly attenuated on the duskside because of the difference in the background winds with vertical shears. We further developed a one‐dimensional photochemical model to investigate the response of the airglow intensity to the change of the eddy diffusion coefficient, which is expected to increase with the wave amplitude. The model showed that a 3.6‐day oscillation of the diffusion coefficient with an amplitude of ~300 m2 s−1 explains the observed airglow intensity variation. A possible cause of the 3.6‐day period is the filtering of gravity wave fluxes by the Kelvin wave‐induced wind.
Probabilistic Categorical Groundwater Salinity Mapping From Airborne Electromagnetic Data Adjacent to California's Lost Hills and Belridge Oil Fields
Authors: Ball L. B. , Davis T.  A. , Minsley B. J. , Gillespie J. M. , Landon M. K. 
Published: March 2020

AbstractGrowing water stress has led to emerging interest in protecting fresh and brackish groundwater as a potential supplement to water supplies and raised questions about factors that could affect the future quality of fresh and brackish aquifers. Limited well infrastructure, particularly in regions where elevated salinity has led to limited historical groundwater development, hinders traditional mapping of salinity distributions through groundwater sampling. This paper presents a quantitative salinity mapping approach of the upper 300 m using high‐resolution, regionally comprehensive resistivity models derived from Bayesian inversion of an airborne electromagnetic survey adjacent to the Lost Hills and Belridge oil fields in the southwestern San Joaquin Valley of California. Using local water quality observations as an interpretational foundation, a probabilistic approach yields maps of fresh, saline, and brackish groundwater while quantifying joint uncertainty inherited from the geophysical data and interpretational relations. Saline and fresh regions are mapped with relatively high confidence in many locations, while areas of lower confidence, particularly at depth, can be mapped as their most probable salinity category while reflecting the relative uncertainty in the interpretation. These maps identify a stratified salinity structure, where saline water commonly occurs in the surficial aquifer overlying fresher groundwater in the Tulare aquifer, separated by regional confining clay layers. Downgradient of unlined surface water diversions, recharge of imported surface water results in relatively fresh groundwater throughout the depth of investigation.