bluuebunny/crossref_metadata_2025_split huggingface dataset:
NEAT1 aggravates sepsis-induced acute kidney injury by sponging
miR-22-3p
Authors: Feng Yawei , Liu Jun , Wu Ranliang , Yang Peng , Ye Zhiqiang , Song Furong 
Published: May 2020

Abstract

Background and aim
Acute kidney injury (AKI) is a common complication of sepsis. Long noncoding RNA
nuclear-enriched abundant transcript 1 (NEAT1) plays a vital role in various
diseases, including AKI. This study aimed to investigate the function and
mechanism of NEAT1 in sepsis-induced AKI.

Materials and methods
A septic AKI model was established by treating HK-2 cells with lipopolysaccharide
(LPS). The levels of NEAT1 and miR-22-3p were measured by quantitative real-time
PCR. Cell apoptosis was assessed by flow cytometry. The levels of
apoptosis-related protein and autophagy-related factors were examined by the
western blot assay. An enzyme-linked immunosorbent assay was used to calculate the
contents of inflammatory factors. The interaction between NEAT1 and miR-22-3p was
validated by dual-luciferase reporter assay, RNA immunoprecipitation assay, and
RNA pull-down assay. The levels of nuclear factor (NF)-κB pathway-related
proteins were evaluated by the western blot assay.

Results
NEAT1 was upregulated, while miR-22-3p was downregulated in patients with sepsis
and in LPS-stimulated HK-2 cells. LPS treatment triggered cell apoptosis,
autophagy, and inflammatory response in HK-2 cells. NEAT1 knockdown attenuated
LPS-induced cell injury. NEAT1 modulated LPS-triggered cell injury by targeting
miR-22-3p. Furthermore, NEAT1 regulated the NF-κB pathway by modulating
miR-22-3p.

Conclusion
Depletion of NEAT1 alleviated sepsis-induced AKI via regulating the
miR-22-3p/NF-κB pathway.
Agamben’s two missing factors; Understanding state of emergency through colonialism and racial doctrine
Authors: Amarasinghe Punsara , Rajhans Sanjay K. 
Published: May 2020

AbstractThe idea of state of exception and sovereignty presented by Italian political philosopher Giorgio Agamben in the aftermath of post September 11 context generated a new discourse in the realms of public law and political philosophy on how law and its protection becomes invalid under state of exception as Agamben showed how suspension of constitutional liberties within so called state of exception legally erases any status of an individual regardless international legal or constitutional norms. However, this article seeks to examine how Agamben had excluded the nature of state of emergency doctrine in colonial societies under European colonialism, where emergency regulations were frequently adopted by colonial masters in subordinating the colonized and at the same time this article will focus on the racial element appeared behind enacting state of emergency in both colonial era and modern states. The objective of this article lies in underpinning much important, yet neglected two factors in whole state of emergency scenario. The results emerging from this article will demonstrate how Eurocentric academic thinking has abandoned some real pertinent issues in constructing the notion on state of emergency.
Bruno Leoni’s Concept of Law and Representation in The Cyber Age: A Cybernetic Model
Authors: De Benedetti Mario 
Published: May 2020

AbstractThe purpose of this article is to contextualize Bruno Leoni’s political theory within the Digital Information Society, a new dimension of public participation in the political arena and a sign of the democratic transition through new forms of involvement by public opinion. In particular, the evolution of the Information Society will be briefly examined starting from the studies of Fritz Machlup, considered its progenitor, to pass to the examination of the Leonian concept of law and politics in the technological society, with reference to Norbert Wiener and Karl Deutsch’s cybernetic theory. This paper will attempt to describe the evolutive process of political participation in democratic society by reinterpreting the thought of Bruno Leoni concerning Democracy, the State and the homo telematicus in the digital social order.
Dissociable Behavioral and Neural Correlates for Target-Changing and Conforming Behaviors in Interpersonal Aggression
Authors: Takami Kyosuke , Haruno Masahiko 
Published: May 2020

AbstractActors in interpersonal aggression such as bullies change their targets frequently, but the underlying behavioral and neural mechanisms are unknown. Here, using the catch-ball task we recently developed to examine human interpersonal aggression, we found target-changing and conforming to other participants’ aggression are major driving forces of increased aggression (i.e., throwing strong balls). We also found that target-changing was correlated with a participant’s extraversion, consistent with a bistrategic view, in which both prosocial and coercive motivations drive interpersonal aggression. In contrast, conforming to others was correlated with social anxiety. In addition, questionnaires about participants’ past experiences of bullying suggested that target-changers and conformers were predominantly bullies and victims in the past. An analysis of resting-state functional magnetic resonance imaging (fMRI) revealed that functional connectivity between the dorsal anterior cingulate cortex (dACC) and insula were correlated with target-changing behavior, while functional connectivity between the amygdala and temporo-parietal junction (TPJ) was correlated with conformity. These results demonstrate that target-changing and conforming behaviors have dissociable behavioral and neural mechanisms and may contribute to real-world interpersonal aggressions differently.
Targeting Morphine-Responsive Neurons: Generation of a Knock-In Mouse Line Expressing Cre Recombinase from the Mu-Opioid Receptor Gene Locus
Authors: Bailly Julie , Del Rossi Natalie , Runtz Léonie , Li Jing-Jing , Park DaWoon , Scherrer Grégory , Tanti Arnaud , Birling Marie-Christine , Darcq Emmanuel , Kieffer Brigitte L. 
Published: May 2020

AbstractThe mu-opioid receptor (MOR) modulates nociceptive pathways and reward processing, and mediates the strong analgesic and addictive properties of both medicinal as well as abused opioid drugs. MOR function has been extensively studied, and tools to manipulate or visualize the receptor protein are available. However, circuit mechanisms underlying MOR-mediated effects are less known, because genetic access to MOR-expressing neurons is lacking. Here we report the generation of a knock-inOprm1-Cre mouse line, which allows targeting and manipulating MOR opioid-responsive neurons. A cDNA encoding a T2A cleavable peptide and Cre recombinase fused to enhanced green fluorescent protein (EGFP/Cre) was inserted downstream of theOprm1gene sequence. The resultingOprm1-Cre line shows intactOprm1gene transcription. MOR and EGFP/Cre proteins are coexpressed in the same neurons, and localized in cytoplasmic and nuclear compartments, respectively. MOR signaling is unaltered, demonstrated by maintained DAMGO-induced G-protein activation, andin vivoMOR function is preserved as indicated by normal morphine-induced analgesia, hyperlocomotion, and sensitization. The Cre recombinase efficiently drives the expression of Cre-dependent reporter genes, shown by local virally mediated expression in the medial habenula and brain-wide fluorescence on breeding with tdTomato reporter mice, the latter showing a distribution patterns typical of MOR expression. Finally, we demonstrate that optogenetic activation of MOR neurons in the ventral tegmental area ofOprm1-Cre mice evokes strong avoidance behavior, as anticipated from the literature. TheOprm1-Cre line is therefore an excellent tool for both mapping and functional studies of MOR-positive neurons, and will be of broad interest for opioid, pain, and addiction research.
Ecological Study on Factors Related to the Mortality of Rabies in North Sulawesi Province at the Year of 2015 to 2017
Authors: Tiarma Noer Syafiiah , Machmud Putri Bungsu 
Published: May 2020

Indonesia, which is part of the region, contributes 25 provinces including areas that have not been free from the endemic of rabies. One of the provinces that ranked top in the cases of rabies was North Sulawesi. Therefore, this study aims to find correlations between factors related to the prevalence of rabies deaths in North Sulawesi Province in 2015 - 2017. This study used a mixed ecological study design by applying the principle of total sampling to 15 districts/citiesin North Sulawesi. The results of the study found that there was a negative and weak strength correlation on the anti rabiesvaccine coverage factor (r = 0.279), moderate strength correlation on the ratio of health care workers (r = 0.345), and the ratio of health care facilities (r = 0.320) to the mortality of rabies. While the sex ratio factor is positive and has moderate strength (r = 0.365) against the mortality of rabies. The new findings of health care facility and health care workers that have a moderate strength correlation need to be included in the prevention of rabies approach because it can help to facilitate washing wounds treatment.
ACTIVIDAD BIOCONTROLADORA IN VITRO DE MACROHONGOS CONTRA DIFERENTES HONGOS FITOPATÓGENOS
Authors: Patiño Moscoso Manuel Alfonso , Nieto Ramírez Ivonne Jeannette , Chegwin Angarita Carolina , Torres Rojas Esperanza 
Published: May 2020

Las enfermedades causadas por hongos en las plantas son una gran preocupación en la producción agrícola. Los macromicetos son una fuente potencial de compuestos antifúngicos que podrían usarse para controlar estas enfermedades. El objetivo de este estudio fue evaluar la actividad biocontroladora in vitro de cuatro macromicetos de los géneros Xylaria, Agrocybe, Psilocybe y Stereum sobre diferentes hongos fitopatógenos. Para ello, se determinó la curva de crecimiento de los macrohongos en dos medios: papa dextrosa (PDA) y salvado de trigo (ST) y se caracterizaron las interacciones y la inhibición in vitro de hongos fitopatógenos. Se realizó la extracción y caracterización de metabolitos secundarios de la biomasa, el medio extracelular y del homogeneizado del micelio y caldo en los hongos con mayor porcentaje de inhibición. Finalmente, se evaluó la actividad antifúngica in vitro de estos extractos. Las curvas de crecimiento cambiaron con la fuente de carbono, tres de cuatro macrohongos mostraron una mayor acumulación de biomasa en PDA que en ST. Las interacciones de Xylaria se clasificaron principalmente como reemplazo, obteniendo el mayor nivel de antagonismo en PDADos de los tres extractos evaluados mostraron actividad antifúngica contra los tres patógenos aislados en concentraciones de 18 μg/ml para extractos metanólicos de biomasa y 2,5 % para el filtrado de homogeneizado con inhibiciones de 10 % a 80 %. La caracterización de los metabolitos de Xylaria mostró como posibles compuestos responsables de la actividad a los ácidos grasos. Este trabajo mostró el potencial de estos hongos para el control de enfermedades fúngicas.
Bases celulares da remodelação óssea e rastreamento de pacientes com redução de densidade mineral óssea em radiografias odontológicas
Authors: IIda Christyan Hiroshi , Girard José , Chagas Mariana , Villafuerte Segio , Arita Emiko , Munhoz Luciana 
Published: May 2020

Objetivo: O principal objetivo desta revisão da literatura é fornecer informações necessárias ao cirurgião-dentista para prover o conhecimento e o reconhecimento da osteoporose, tanto no âmbito biológico celular quanto radiográfico. Resultados:A osteoporose é uma doença sistêmica que afeta o metabolismo ósseo, alterando sua microarquitetura e diminuindo a densidade mineral óssea (DMO) sem produzir variações em sua composição química. Afeta preferencialmente ossos com grande quantidade de tecido ósseo trabecular, como a mandíbula. A redução da densidade mineral óssea da mandíbula pode ser verificada por meio de radiografias panorâmicas. A diminuição da densidade óssea na mandíbula é um dos sinais de alerta de osteoporose. Conclusões: É essencial que o cirurgião-dentista possa avaliar criticamente a qualidade óssea da mandíbula, incluindo seus aspectos biológicos e radiográficos para o planejamento adequado dos tratamentos.
Aural Speed-Reading: Some Historical Bookmarks
Authors: Mills Mara , Sterne Jonathan 
Published: May 2020

Together they are writing a book entitled “Tuning Time: Histories of Sound and Speed.” The authors would like to thank the Epistemes of Modern Acoustics group at the Max Planck Institute for the History of Science, the Alexander von Humboldt Foundation, Jason Camlot, Iben Have, Burç Kostem, and Shafeka Hashash.We write the history of aural speed-reading and time-stretching technology in two tracks, taking a cue from Annemarie Mol'sThe Body Multiple: Ontology in Medical Practice, with its “upper text” and “subtext” that invite readers “to invent a way of reading that works for them from scratch” (ix). In the spirit of the story that opens track 1, on the left, we decided to jimmy the format of thePMLApage. To differing degrees, each track provides context, describes events, raises questions, and applies analytic frames. Track 1 is our narration of a series of events recalled by Harvey Lauer to Mara Mills; the insights derive from his professional expertise and personal reading experiences. Track 2, on the right, does not benefit from the kind of omniscient sight known as hindsight; it reads alongside. Think of these tracks as an animated and mostly asynchronous conversation among people who care about instruments of sound and reading in distinct but similarly fanatical ways. For a cluster of historical recordings associated with this essay, tune in to theSound and Science: Digital Historiesdatabase: acoustics.mpiwg-berlin.mpg.de/sets/clusters/aural-speed-reading.
Endometri̇al Örnekleme Sonuçlarımız: 365 Olgunun Analizi
Authors: TURHAN ÇAKIR Anıl , ÖZ İsa Şükrü , ÜN Burak 
Published: May 2020

Amaç: Çalışmamızın
amacı çeşitli nedenler ile yapılan
endometri­al örnekleme işleminin; endikasyonları ve histopatolojik
tanılarının değerlendirilmesi

Materyal ve metod: Bu
çalışmada Ocak 2015-Mart 2018 tarihleri arasında kliniğimiz­de
çeşitli nedenler ile endometrial biyopsi yapılan 365 hastanın
endometrial biyopsi sonuçları retrospektif olarak
değerlendirildi

Bulgular: Hastaların
yaş ortalaması 46,7±9,9 idi. Endometrial biyopsi endikasyonları sırasıyla
anormal uterin kanama (%74), postmenopozal kanama (%11,5)ve postmenopozal
endometrial kalınlık artışı (%14,5) .Histopatolojik sonuçlar ise en sık proliferatif
endometrium (%32,1)
sonrasında sırasıyla sekretuar endometrium (%23) endometrial polip (%16,4) yetersiz materyal (%12,9), atrofi (%8,8), basit atipisiz
endometrial hiperplazi (%5,2), endometrial kanser (%1,1) olarak raporlanmıştır.
Premenopozal dönemde sekretuar endometrium ve proliferatif endometrium yüksek
oranda bulunurken (p&lt;0.001); postmenopozal dönemde ise atrofi (p&lt;0.001),
yetersiz materyal (p&lt;0.001) ve endometrium kanseri (p=0.004) yüksek oranda
bulundu.

Sonuç: Endometrial biyopside esas amaç
endometrium kanserini saptamaktır. Özellikle postmenopozal dönemde endometrium
kanseri açısından dikkatli olunmalıdır

Anahtar kelimeler: uterus kanaması;
endometriyal hastalıklar; menoraji
Niveles e actividad física de niños y adolescentes durante el descanso en la escuela, un estudio observacional con el uso de Soplay
Authors: Arias Elkin Alberto Arias 
Published: May 2020

Marco teórico: La práctica de Actividad Física (AF) en la escuela es muy importante para los niños de hogares de bajos ingresos ubicados en zonas de- primidas. Estos niños no pueden tener acceso a programas extraescolares de AF debido a la falta de ofertas adecuadas en la zona, los problemas de seguridad, por estar en situación de niño trabajador o por falta de recursos financieros (Blatchtford, Baines y Pellegrini, 2003). La escuela parece ser un lugar apropiado para moverse durante el descanso. Sin embargo, no está claro cómo los factores ambientales en el patio de la escuela influyen en los niveles de AF de niños con edades diferentes. También existen importantes diferencias en la AF de los niños y adolescentes. La necesidad innata de moverse puede contribuir a los niveles de AF más altos en los niños que en los de los adolescentes, incluso en ambientes similares (Rowland & Hughes, 2006). Objetivo: En este estudio se compararon los niveles de actividad física de los niños y adolescentes que comparten la misma es- cuela (los adolescentes van a la escuela por la mañana, los niños van por la tarde). Método: Los observadores utilizaron el sistema SOPLAY (System for Observing Play and Leisure Activity in Youth) (McKenzie, 2000) para obtener datos sobre la cantidad y el tipo de AF que practican los niños y adolescentes durante los descansos. Resultados: Los resultados indican que el 52, 7% de los estudiantes no realizan ningún tipo de AF durante el reposo y permanecen sedentarios, el 27,2% practica AF de moderada intensidad, el 20,1% practica AF vigorosa. 47, 3% de los escolares y adolescentes practican actividad física de moderada a vigorosa intensidad (MVPA). Los resultados muestran diferencias significativas (p <0,5) entre los niños y adolescentes, los niños son más activos durante el receso esco- lar que los adolescentes.
La inmersión en agua fría no reduce los marcadores de daño muscular en nadadores
Authors: Agualimpia Yeimer Andres Sanclemente , Giraldo García Juan Carlos 
Published: May 2020

Objetivo: Determinar el efecto de la inmersión en agua fría sobre los marcadores de daño muscular inducidos por el ejercicio excéntrico. Metodología: Estudio cuasi-experimental, 15 hombres nadadores, 10 en el grupo de tratamiento y 5 el grupo control. Luego del protocolo excéntrico (2 series de 10 repeticiones en extensión de rodilla), el grupo de tratamiento tuvo 15 minutos de inmersión en agua a fría a 15 °C ± 1 °C y el grupo control tuvo 15 minutos de inmersión en agua a termoneutra a 32 °C ± 1 °C. Las variables (CK, LDH, salto vertical, potencia y percepción del dolor) se registraron a las 24, 48 y 72 horas posteriores a la intervención. Resultados: La inmersión en agua fría no tiene efectos estadísticamente significativos en la reducción de los marcadores de daño muscular.
Prospects for the use of chondroitin sulfate and glucosamine sulfate with osteoarthritis associated with pathology of the kidneys and urinary system
Authors: Torshin I. Yu. , Lila A. М. , Limanova O. A. , Gromova O. A. 
Published: May 2020

Introduction. Chondroitin sulfate (CS) and glucosamine sulfate (GS), widely used as chondroprotectors, can maintain the normal functioning of the urinary system but their effect has not been analyzed systematically.Aim: to perform a systematic analysis of the possibilities of using CS and GS in patients with pathology of the kidneys and urinary system.Materials and methods. Predictive analysis of 2,093 publications on the interactions of CS/GS with the functioning of the kidneys and other organs of the urinary system found at the request “(urinary OR bladder OR kidney) AND (glucosamine OR chondroitin)” by methods of the theory of topological data analysis.Results. Disorders of cholesterol and glucosamine metabolism are characteristic of cystitis, glomerular nephritis, urinary tract infections (UTIs), urolithiasis, proteinuria, and formation of diabetic nephropathy. In addition to inhibiting the pro-inflammatory cascade NF-kB, CS/GS contribute to eliminating the deficiency of glycosaminoglycans in the pathology of urothelium, inhibit urolithiasis, inhibit the synthesis of pro-inflammatory nitric oxide NO in macrophages, and modulate O-glycosylation processes.Conclusion. The results of fundamental and clinical studies show that subsidies of CS/GS substances of pharmacological quality per os and CS instillation in the bladder (in particular, in combination with hyaluronic acid) are the means of choice for patients suffering from osteoarthritis and diseases of the urinary system. Highly purified pharmacological CS substances are part of the preparation Chondroguard.
Use of hydroxychloroquine for novel corona virus infection in India: is it ethically justifiable?
Authors: Verma Ramesh , Chayal Vinod , Kalhan Meenakshi , Dhaka Rohit , Agrawal Ginni , Jain Piyush , Singh Tarun 
Published: May 2020

Coronavirus disease is caused by a novel virus belonging to the family of corona viruses similar to severe acute respiratory syndrome (SARS) and name given to the novel virus as SARS Coronavirus- 2 (SARS-CoV-2) and the disease was named as COVID-19 on 11th February 2020 by World Health Organization (WHO). First case of this infection was reported in December 2019 in Wuhan city of China and after that it spread globally.3 On 30th January 2020, WHO declared this disease as Public Health Emergency of International Concern (PHEIC) and on 11th March 2020, WHO declared it as a pandemic when the infection was reported from all six WHO regions.
Comparative study of fixation of intertrochanteric fracture of the femur by proximal femur nail versus dynamic hip screw
Authors: Shivakumar H. B. , Yatish Ramalingaiah , Seetharam Channappa T. , Jayaram Manju , Kamath K. Amith 
Published: May 2020

<p class="abstract"><strong>Background:</strong> Intertrochanteric fractures are common in old age group, but uncommon in younger age group. The goal of treatment of intertrochanteric fractures is restoration to pre-injury status at the earliest. The purpose of this study is to compare the functional outcome of the two fixation devices proximal femur nail (PFN) and dynamic hip screw available for intertrochanteric fractures in terms of the eventual functional outcome of the patient.</p><p class="abstract"><strong>Methods:</strong> Prospective study of 30 cases of Intertrochanteric fractures admitted and operated in KIMS hospital from November 2017 to May 2019. Follow-up of these patients was done at 6 weeks, 12 weeks and 24 weeks with functional evaluation was done using Harris hip score at the 24th week.<strong></strong></p><p class="abstract"><strong>Results:</strong> The results at the end of 24 weeks follow-up were calculated by the Harris hip score were better with the PFN. 66.7% of the patients operated with PFN gave excellent results as compared to 60% of patients operated with dynamic hip screw (DHS).</p><p class="abstract"><strong>Conclusions:</strong> We conclude that the use of PFN for the fixation of trochanteric fractures against the proven DHS offered better results along with a few advantages. PFN required smaller incision, shorter duration of surgery, less blood loss and faster recovery and better functional outcome at the end of 24 weeks. But still PFN is technically more demanding than the DHS and was found to have longer fluoroscopy exposure.</p><p class="abstract"> </p><p> </p>