bluuebunny/crossref_metadata_2025_split huggingface dataset:
CNAs’ Ratings of Nursing Home Residents’ Pain: The Role of CNA and Resident Traits
Authors: Behrens Emily , Noh Hyunjin , Snow A Lynn , Parmelee Patricia 
Published: December 2020

Abstract
Long-term care residents with and without cognitive impairment may experience undertreatment of persistent pain (Fain et. al, 2017). Certified nursing assistants (CNAs) are important sources of information about resident pain as they provide the majority of residents’ hands-on care. Therefore, assessing the accuracy of CNAs’ pain assessments and potential influencing factors may provide insight regarding the undertreatment of pain. Informed by prior research, this study examined resident pain catastrophizing and cognitive status as predictors of CNAs’ pain assessment accuracy. CNA empathy was examined as a moderating variable. Analyses confirmed a relationship between pain catastrophizing and CNA pain rating accuracy (R^2 = .205, p &lt; .01), reflecting lower accuracy of ratings for residents higher in catastrophizing. Hypotheses predicting a relationship between resident cognitive status and CNA pain rating accuracy and moderating effects of empathy were disconfirmed. Challenges of conducting research in long-term care are discussed.
Video Intervention to Increase Knowledge About and Interest in Palliative Care Among MSW Students
Authors: Berkman Cathy 
Published: December 2020

Abstract
As the population ages and more people live longer with chronic and life-limiting illnesses, more healthcare professionals with palliative care skills are needed. Social workers are part of the palliative care team, but there is little, if any, content on palliative and end-of-life care in MSW programs. A 24-minute video featuring nine palliative and hospice social workers was produced with two goals: 1) increase knowledge of social work students about palliative and end-of-life care; and 2) interest social work students in a career in palliative social work. MSW students from three schools, in NY and Alabama, viewed the video. After viewing the video, 94 students participated in the mixed methods study, completing the brief, anonymous, online survey. The mean level of understanding about what palliative social workers do, rated from 1 (no understanding) to 5 (very good understanding), was 2.96 (SD=.99) before viewing the video and 4.31 (SD=.61) after, for an increase of 1.35 points (95% CI=1.14, 1.55) (p&lt;.001). The mean level of interest in a career in palliative care social work and working with seriously ill persons and their family members, rated from 1 (Not at all interested) to 5 (Extremely interested), was 2.52 (SD=.99) before viewing the video and 3.45 SD=.80) after, for an increase of .91 points (95% CI=.79, 1.07) (p&lt;.001). Qualitative data supporting the quantitative findings will be presented. This study suggests that a video intervention may be an effective tool to increase knowledge and interest in palliative and end-of-life care among social work students.
Leveraging Assistive Technology Resources to Support Aging in Place: A Scoping Study
Authors: Mois George , Beer Jenay 
Published: December 2020

Abstract
Aging in place is the preferred living arrangement for most older adults. However, the challenges that often accompany longevity coupled with housing which lacks proper modifications presents concerns about older adults’ safety and wellbeing. Advancements in assistive technologies have promising potential in helping address many of these challenges and support aging in place. The purpose of this scoping review was to survey the current literature to understand why, how, and what assistive technologies are adopted and utilized to help support aging in place. We followed the Arksey and O’Malley (2005) methodological framework for scoping studies, searching seven databases and systematically assessed 611 titles/articles. Findings were organized using frequencies and themes. Following the inclusion/exclusion criteria, 12 articles were included. Upon thematic analysis, three main themes emerged: 1.) challenges experienced in the context of aging in place, 2.) technology adoption, and 3.) technology types and applications. Findings indicate technology can serve an important role in helping support aging in place and can serve as a medium to deliver and increase access to resources to support physical, social, and psychological wellbeing. The technologies most frequently utilized include personal devices and smart home technologies. The adoption and use of technologies can be impacted by the perceived ease of use, perceived usability, family/caregiver, self-selection, involvement in technology development, policies supporting access, and environment factors. Our findings indicate that there is a current gap in the understanding of how older adults are interacting with technology and how long term use impacts wellbeing and aging in place.
The Inventory of Physical Activity Barriers: Development and Preliminary Validation
Authors: Wingood Mariana , Gell Nancy , Peters Denise , Hutchins Tiffany 
Published: December 2020

Abstract
Inactivity levels among community-dwelling adults 50 years and older is a healthcare concern, particularly when examining the association between increasing age, inactivity, and risk of non-communicable diseases. To confront this concern, healthcare providers need to address the reasons for inactivity. Unfortunately, limited tools exist to address barriers of physical activity (PA). The purpose of our study was to develop and psychometrically evaluate a PA barrier scale for adults 50 years and older. The scale is called the Inventory of Physical Activity Barriers (IPAB) and it was developed, refined, and evaluated using a cross-sectional and a modified Delphi study. We had two groups of participants: 39 adults (50 years and older) provided survey pilot data for psychometric evaluation, and nine interprofessional PA experts assisted with finalizing the scale. Participants completed a demographic questionnaire, Physical Activity Vital Sign questionnaire, and IPAB. The IPAB’s refinement was guided by item-scale correlations, descriptive statistics, and consensus among the PA experts. Construct validity was examined by comparing mean IPAB scores of inactive and active participants via independent t-test. Internal consistency was assessed via Cronbach Alpha. The IPAB was refined from 172 items to 40 items and found to be internally consistent (α=.97) and able to differentiate individuals who do and do not meet the recommended 150 minutes of weekly PA (p=0.01). These preliminary results show the IPAB is a reliable assessment of PA barriers for adults 50 years and older, and are promising for the scale’s construct validity and support further psychometric evaluation of the tool.
Ability and Performance of Daily Activity for Older Adults With Multiple Chronic Conditions
Authors: Klinedinst Tara , Rodakowski Juleen 
Published: December 2020

Abstract
Older adults with multiple chronic conditions (MCC), and especially with added depression, have lower levels of daily activity than those without MCC. Engagement in daily activities can be measured by ability (what individuals can do) and performance (what individuals actually do). Understanding this difference is critical to developing interventions that align with the daily activity needs of older adults with MCC. The aim of this study was to understand the relationships between ability and performance of instrumental activities of daily living (IADL) among older adults with varied MCC and depression status. We conducted a cross-sectional study using data from the National Health and Aging Trends Study. We used MANOVA to detect differences in ability and performance of IADL by MCC status and t-tests to test the difference between ability and performance for our sample. There was an effect of MCC status on ability and performance for older adults in this sample, F (10,13386) = 67.12, p &lt; .001, ηp2 = .05; performance and ability were lowest for MM-D, and highest for no MCC. Post-hoc t-tests revealed a difference between the mean scores for ability (M = .79, SD = .29) and performance (M = .92, SD = .23) across all groups of MCC status, t (6693) = -50.174, p &lt; .001. Older adults with MCC, particularly with depression, displayed diminished performance of IADL, although they have the ability. Our results suggest interventions should not only address what individuals can do, but also what they actually do in their context.
An Advance Care Planning Group Visit Intervention for Individuals With Mild Cognitive Impairment
Authors: Daddato Andrea , Shanbhag Prajakta , Bettcher Brianne , Lum Hillary 
Published: December 2020

Abstract
Among older adults without cognitive impairment, a novel advance care planning group visit (ACP-GV) intervention increased ACP documentation and readiness to engage in ACP. A key question is whether an intervention can be adapted to support people with mild cognitive impairment (MCI) and a family care partner. We used a human-centered design process, rapid-cycle prototyping, and qualitative methods to adapt an ACP-GV intervention to individuals with MCI and a study partner. In 2019, we convened a longitudinal cohort of six patient-study partner stakeholders in three focus groups to suggest intervention adaptations. We also conducted a single arm study of four ACP-GV interventions (n=13 dyads total) that were iteratively refined with input from the longitudinal focus groups and intervention participant feedback. Decision tools, resources and videos were used to describe the concept of ACP and flexibility in selecting a medical decision maker. Many ACP-GV participants strongly agreed that the group discussion gave them useful information (81%) and would recommend the ACP-GV to a friend (85%). Pre- and post-ACP readiness surveys indicated that participants were significantly more ready to talk to their medical decision maker about ACP (p=0.028), while study partners perceived their loved ones less ready to speak to their doctor about ACP following the intervention (p=0.031). Use of rapid prototyping allowed testing of different resources and tools aimed at helping individuals with MCI and their study partners discuss ACP. Future work is needed to understand the feasibility of implementing an ACP-GV intervention for individuals with MCI into clinical settings.
Dementia-Related Anxiety and General Illness Anxiety Differ Based on Familial Exposure to Persons With Dementia
Authors: Fenstermacher Erika , Ebert Alexandria , Shook Natalie , Lee Jerin , Wilson Jenna , Haliwa Ilana 
Published: December 2020

Abstract
Dementia-related anxiety is a specific form of illness anxiety that has been associated with familial exposure to persons with dementia (FMwDs). However, it is unknown whether FMwDs is specifically associated with dementia-related anxiety or whether it is also related to general illness anxiety, which has broader health implications. Furthermore, the level of exposure to family members with dementia may matter. Thus, we examined whether level of familial exposure to dementia was related to general illness anxiety and dementia-related anxiety. Participants (N = 401) aged 18-76 years (M = 39) recruited through Amazon’s Mechanical Turk completed an online survey. Dementia exposure was split into three levels: (1) not knowing a friend/family member with dementia (55.2%); (2) knowing a family member with dementia (33.9%); and (3) providing care for a family member with dementia (10.9%). Familial exposure to dementia was related to both general illness anxiety and dementia-related anxiety. Participants who provided care for FMwDs had significantly higher levels of illness anxiety than both people who had a FMwD and people who did not (ps &lt; .001). Similarly, participants who provided care for FMwDs had significantly higher levels of dementia-related anxiety than participants who did not have a FMwD (p &lt; .01). Caregivers play a critical role in the quality of life of those with dementia, however it is clear that the potential psychological impact of such work is pervasive. This study provides a foundation to explore differences between illness anxiety and dementia worry, and examine interventions to reduce anxiety among caregivers.
Effect of Rosuvastatin Therapy on Biomarkers of Inflammation and Immune Activation in People With Human Immunodeficiency Virus at Intermediate Cardiovascular Risk
Authors: Hearps Anna C , Angelovich Thomas A , Trevillyan Janine M , Wong Michelle E , Calmy Alexandra , Hoy Jennifer F , Jaworowski Anthony 
Published: December 2020

Abstract

Background
Statins may help prevent cardiovascular disease (CVD) in people with human immunodeficiency virus (PWH) with chronic inflammation owing to their pleotropic lipid-lowering and anti-inflammatory properties.

Methods
The impact of 48 weeks of rosuvastatin therapy on inflammation and immune activation in a double-blind, placebo-controlled trial in PWH at moderate cardiovascular disease risk was assessed.

Results
Rosuvastatin did not alter plasma levels of interleukin 6, soluble tumor necrosis factor receptor type 2, CXCL10, soluble CD14, or soluble vascular cellular adhesion molecule 1 (P ≥ .1 for all). Proportions of CD16+ monocyte subsets were increased in PWH receiving rosuvastatin.

Conclusions
The potential benefits of statin use in PWH with normal lipid levels requires further clinical outcome research.
Magnetic field and chromospheric activity evolution of HD 75332: a rapid magnetic cycle in an F star without a hot Jupiter
Authors: Brown E L , Marsden S C , Mengel M W , Jeffers S V , Millburn I , Mittag M , Petit P , Vidotto A A , Morin J , See V , Jardine M , González-Pérez J N ,   The BCool Collaboration
Published: December 2020

ABSTRACT
Studying cool star magnetic activity gives an important insight into the stellar dynamo and its relationship with stellar properties, as well as allowing us to place the Sun’s magnetism in the context of other stars. Only 61 Cyg A (K5V) and τ Boo (F8V) are currently known to have magnetic cycles like the Sun’s, where the large-scale magnetic field polarity reverses in phase with the star’s chromospheric activity cycles. τ Boo has a rapid ∼240 d magnetic cycle, and it is not yet clear whether this is related to the star’s thin convection zone or if the dynamo is accelerated by interactions between τ Boo and its hot Jupiter. To shed light on this, we studied the magnetic activity of HD 75332 (F7V) which has similar physical properties to τ Boo and does not appear to host a hot Jupiter. We characterized its long-term chromospheric activity variability over 53 yr and used Zeeman Doppler Imaging to reconstruct the large-scale surface magnetic field for 12 epochs between 2007 and 2019. Although we observe only one reversal of the large-scale magnetic dipole, our results suggest that HD 75332 has a rapid ∼1.06 yr solar-like magnetic cycle where the magnetic field evolves in phase with its chromospheric activity. If a solar-like cycle is present, reversals of the large-scale radial field polarity are expected to occur at around activity cycle maxima. This would be similar to the rapid magnetic cycle observed for τ Boo, suggesting that rapid magnetic cycles may be intrinsic to late-F stars and related to their shallow convection zones.
A Preoperative Contingency Management Intervention for Smoking Abstinence in Cancer Patients: A Preliminary Randomized Controlled Trial
Authors: Rojewski Alana M , Fucito Lisa M , Baker Nathaniel L , Krishnan-Sarin Suchitra , Carpenter Matthew J , Bernstein Steven L , Toll Benjamin A 
Published: December 2020

Abstract

Introduction
The purpose of this study was to evaluate a pilot preoperative contingency management (CM) intervention for smoking abstinence.

Aims and Methods
This multisite pilot study was conducted at two cancer center-based tobacco treatment programs. Participants who were smoking, diagnosed with or suspected to have any type of operable cancer, and had a surgical procedure scheduled in the next 10 days to 5 weeks (N = 40) were randomized to receive standard care plus monitoring only (MO) or CM prior to surgery. All patients received breath carbon monoxide (CO) tests 3 times per week, nicotine patches, and counseling. The CM group also earned payments for self-reported smoking abstinence confirmed by CO breath test ≤6 ppm on an escalating schedule of reinforcement (with a reset if they smoked). Seven-day point prevalence abstinence rates on the day of surgery and at 3-month follow-up were compared between groups using repeated measures log-linear regression models utilizing generalized estimating equations. Participants lost to follow-up are assumed to have returned to smoking.

Results
The sample was 50% female and 75% White. In covariate adjusted models, patients in the CM group had a greater probability of reported abstinence. On the day of surgery (end of treatment), 52% of CM patients were abstinent compared with 16% of patients in MO (risk ratio = 3.2 [1.1–9.3]; p = .03). At the 3-month follow-up, 43% of CM patients were abstinent compared with 5% in MO (risk ratio = 8.4 [1.5–48.3]; p = .02).

Conclusions
Providing monetary incentives contingent on abstinence prior to cancer surgery may produce significant improvements in smoking abstinence rates relative to breath CO MO.

Implications
In this pilot preoperative CM intervention for smoking abstinence, patients receiving a CM intervention prior to cancer surgery had a greater probability of smoking abstinence at the end of treatment compared with a breath MO group (52% vs. 16%, respectively). Thus, providing monetary incentives contingent on abstinence may produce significant improvements in smoking abstinence rates prior to cancer surgery relative to breath CO monitoring.
Two independent mouse lines carrying the Nav1.7 I228M gain-of-function variant display dorsal root ganglion neuron hyperexcitability but a minimal pain phenotype
Authors: Chen Lubin , Wimalasena Nivanthika K. , Shim Jaehoon , Han Chongyang , Lee Seong-Il , Gonzalez-Cano Rafael , Estacion Mark , Faber Catharina G. , Lauria Giuseppe , Dib-Hajj Sulayman D. , Woolf Clifford J. , Waxman Stephen G. 
Published: December 2020

Abstract
Small-fiber neuropathy (SFN), characterized by distal unmyelinated or thinly myelinated fiber loss, produces a combination of sensory dysfunction and neuropathic pain. Gain-of-function variants in the sodium channel Nav1.7 that produce dorsal root ganglion (DRG) neuron hyperexcitability are present in 5% to 10% of patients with idiopathic painful SFN. We created 2 independent knock-in mouse lines carrying the Nav1.7 I228M gain-of-function variant, found in idiopathic SFN. Whole-cell patch-clamp and multielectrode array recordings show that Nav1.7 I228M knock-in DRG neurons are hyperexcitable compared with wild-type littermate-control neurons, but despite this, Nav1.7 I228M mice do not display mechanical or thermal hyperalgesia or intraepidermal nerve fiber loss in vivo. Therefore, although these 2 Nav1.7 I228M knock-in mouse lines recapitulate the DRG neuron hyperexcitability associated with gain-of-function mutations in Nav1.7, they do not recapitulate the pain or neuropathy phenotypes seen in patients. We suggest that the relationship between hyperexcitability in sensory neurons and the pain experienced by these patients may be more complex than previously appreciated and highlights the challenges in modelling channelopathy pain disorders in mice.
A 3-Decade Analysis of Pancreatic Adenocarcinoma After Solid Organ Transplant
Authors: Corral Juan E. , Croome Kristopher P. , Keaveny Andrew P. , Brahmbhatt Bhaumik , Kröner Paul T. , Wijarnpreecha Karn , Goswami Rohan M. , Raimondo Massimo , Wallace Michael B. , Bi Yan , Mousa Omar Y. 
Published: December 2020

Objective
Solid organ transplant (SOT) recipients have moderately increased risk of pancreatic adenocarcinoma (PAC). We evaluated the incidence and survival of PAC in 2 cohorts and aimed to identify potential risk factors.

Methods
This study performed a retrospective cohort analysis. Cohort A was extracted from the United Network of Organ Sharing data set and cohort B from SOT recipients evaluated at 3 Mayo Clinic transplant centers. The primary outcome was age-adjusted annual incidence of PAC. Descriptive statistics, hazard ratios, and survival rates were compared.

Results
Cohort A and cohort B included 617,042 and 29,472 SOT recipients, respectively. In cohort A, the annual incidence rate was 12.78 per 100,000 in kidney-pancreas, 13.34 in liver, and 21.87 in heart-lung transplant recipients. Receiving heart-lung transplant, 50 years or older, and history of cancer (in either recipient or donor) were independent factors associated with PAC. Fifty-two patients developed PAC in cohort B. Despite earlier diagnosis (21.15% with stage I–II), survival rates were similar to those reported for sporadic (non-SOT) patients.

Conclusions
We report demographic and clinical risk factors for PAC after SOT, many of which were present before transplant and are common to sporadic pancreatic cancer. Despite the diagnosis at earlier stages, PAC in SOT portends a very poor survival.
Neurocognitive Effects of Antiretroviral Initiation Among People Living With HIV in Rural Uganda
Authors: Vecchio Alyssa , Robertson Kevin , Saylor Deanna , Nakigozi Gertrude , Nakasujja Noeline , Kisakye Alice , Batte James , Mayanja Richard , Anok Aggrey , Reynolds Steven J. , Quinn Thomas C. , Gray Ronald , Wawer Maria J. , Sacktor Ned , Rubin Leah H. 
Published: December 2020

Background:
HIV-associated neurocognitive disorders remain prevalent despite effective antiretroviral therapy (ART), but there are limited longitudinal data on people living with HIV (PLWH) in sub-Saharan Africa. We examined neuropsychological (NP) performance in PLWH in a longitudinal study in Uganda.

Methods:
Participants enrolled through the Rakai Community Cohort Study (400 ART-naive PLWH and 400 matched HIV-negative persons) were administered NP assessments. In 2017, PLWH who had initiated ART underwent a 2-year follow-up assessment. Demographically adjusted Z-scores for each NP test were established using data from the HIV− controls. Multivariable linear and logistic regressions were conducted to examine group differences in NP performance. Mixed-effects regressions were conducted to examine ART-related changes in NP outcomes.

Results:
Of 333 PLWH who returned for their 2-year follow-up visit, 312 (94%) had initiated ART. Those on ART had a mean age of 35.6 years (SD ± 8.5 years) and mean education of 5.4 years (SD ± 3.3 years); 49% were women. ART-associated NP improvements occurred in verbal learning and memory (P's < 0.05), motor (P's < 0.01), and some measures of processing speed (P = 0.002), whereas there were declines in attention/working memory (P's < 0.001) and semantic fluency (P < 0.001). Pre-ART CD4 count and efavirenz use were associated with a more impaired change in NP performance.

Conclusions:
PLWH in this resource-limited setting showed improved neurocognitive performance on most NP tests after ART initiation. However, the declines in attention/working memory and fluency performance, as well as relationship to efavirenz, warrant further study.