bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Randomized Trial of Continuous Versus Intermittent Skin-to-Skin Contact After Premature Birth and the Effects on Mother–Infant Interaction
Authors: Sahlén Helmer Charlotte , Birberg Thornberg Ulrika , Frostell Anneli , Örtenstrand Annica , Mörelius Evalotte 
Published: November 2019

Background:
Premature birth affects opportunities for interaction between infants and mothers. Skin-to-skin contact (SSC) is standard care in neonatal care but has not been sufficiently studied regarding the effects on interaction between preterm infant and mothers.

Purpose:
The purpose of this study was to compare interaction between preterm infants and their mothers after continuous versus intermittent SSC from birth to discharge. A secondary aim was to study a potential dose–response effect between time in SSC and quality of interaction.

Methods:
Families were randomly assigned to either continuous (n = 17) or intermittent (n = 14) SSC before delivery. Interaction was measured from videotapes of a Still-Face Paradigm collected at 4 months' corrected age. Face-to-face interaction was coded according to Ainsworth's Maternal Sensitivity Scales and the Maternal Sensitivity and Responsivity Scales-R. Dose–response correlations were calculated between mean time spent in SSC and each of the interaction scales.

Results:
There were no statistically significant differences between groups in maternal interactive behavior toward their infants regarding sensitivity, interference, availability, acceptance, withdrawal, or intrusivity. There was no correlation between mean time in SSC and quality of interaction.

Implications for Practice:
Continuous SSC from birth to discharge was not superior to intermittent SSC concerning mother–infant interaction between preterm infants and their mothers at 4 months' corrected age. However, compared with other studies, mean time in SSC was also high in the intermittent group.

Implications for Research:
Further studies are needed to find out how interaction between parents and preterm infants can be improved, supported, and facilitated in the neonatal intensive care unit (NICU) and whether there is an optimal dose for SSC.
Demographics, risk factors, and complication or readmission rates after multiligament knee reconstruction: A retrospective cohort study
Authors: Sivasundaram Lakshmanan , Paliobeis Andrew , Labelle Mark W. , Kim Chang-Yeon , Trivedi Nikunj N. , Karns Michael J. , Salata Michael J. , Voos James E. 
Published: November 2019

Background:
Multi-ligament knee injuries are complex and relatively rare injuries. As a result outcome data available to guide treatment are limited, and management strategies often are debated.

Methods:
Patients who underwent multiligament knee reconstructions between 2005 and 2015 were identified in the National Surgical Quality Improvement Program (NSQIP) database using validated CPT codes. Thirty-day complication and readmission rates after multiligament knee repair or reconstruction were identified. A multivariable logistic regression model was then used to identify statistically significant associations between patient factors and outcomes.

Results:
We identified 481 patients with an average age of 30.1±14.9 yr, and 67.2% male predominance. Using the American Society of Anesthesiologists (ASA) classification system, 222 patients (46.2%) were “Healthy” (ASA 1), 218 patients (45.3%) had “Mild Systemic Disease” (ASA 2), and 38 (7.9%) patients had “Severe Systemic Disease” (ASA 3). Of the sample 96.3% underwent multiligament knee reconstruction on an outpatient basis with 75.9% (365 patients) of the procedures performed in an outpatient surgery center. At 30-days postoperatively, the sample had a 6.2% overall complication rate; 4.8% of patients had a minor complication, and 1.5% of patients had a major complication. The most common minor and major complications were superficial surgical site infection and pulmonary embolus, respectively.

Conclusions:
Multiligament knee injuries commonly occur in young, relatively healthy individuals. This study indicates that reconstructive procedures are quite safe and supports the premise that multiligament knee reconstructions can be safely performed even as an outpatient.

Level of Evidence:
Level III.
Differential Efficacy of Anti-VEGF Antibodies Based on Sex and Race in a Diverse Cohort of Advanced Nonsquamous Non–Small Cell Lung Cancer
Authors: Sukrithan Vineeth , Barbaro Alexander , Chergui Adel , Ko Brian , Lin Juan , Cheng Haiying , Goel Sanjay 
Published: November 2019

Objectives:
Bevacizumab with chemotherapy improved overall survival (OS) in the E4599 trial in metastatic nonsquamous non–small cell lung cancer (NS-NSCLC). A meta-analysis demonstrated an OS benefit with bevacizumab only in a subset of nonwhite patients. We explored the efficacy of antivascular endothelial growth factor antibodies (AVA) in a diverse cohort.

Materials and Methods:
Patients with advanced (stage IIIB/IV, American Joint Committee Cancer 7th edition) recurrent or metastatic NS-NSCLC diagnosed January 2006 to December 2017 at a single medical center were included. Survival analysis was performed with log-rank testing of the Kaplan-Meier estimator. Univariate models were constructed, and significant variables, age, sex, race were incorporated into a multivariate Cox proportional hazard model. Data analysis was performed on SAS.

Results:
A total of 171 patients, 80 were treated with AVA and 91 were untreated. Median age: 63 years, 55% females, 19% non-Hispanic whites, 44% blacks and 32% Hispanic whites; median 40 pack-years of smoking; 11.7% had sensitizing epidermal growth factor receptor mutations. Patients who received AVA had a survival benefit (26.6 vs. 19 mo, P=0.025). Adjusting for age, sex, race/ethnicity, epidermal growth factor receptor mutations, Eastern Cooperative Oncology Group performance status and number of metastases; AVA therapy was associated with improved OS (adjusted hazard ratio=0.62; P=0.049). In a subgroup analysis, females had survival benefit with AVA (median survival: 29.1 vs. 14.2 mo, log-rank P=0.02) which was significant in the adjusted model (adjusted hazard ratio=0.52; P=0.049).

Conclusions:
In a diverse cohort of patients with advanced NS-NSCLC, a survival benefit was confirmed with AVA. The greatest magnitude of benefit was in blacks and non-Hispanic whites. A significant survival benefit was limited to female patients.
Cutaneous Metastases From a Cribriform Adenocarcinoma of the Minor Salivary Glands
Authors: Boyd Alan S. 
Published: November 2019

Abstract:
Cutaneous metastases from solid tumor malignancies often emanate from breast, gastrointestinal, and lung tumors. Adenocarcinomas from minor salivary gland cancers may involve the skin contiguously but rarely as metastatic deposits. Furthermore, these metastases are usually locoregional and not distal. Recently, an uncommon neoplasm termed cribriform adenocarcinoma of the minor salivary glands has been described, and although it often spreads to cervical lymph nodes, metastatic involvement of the skin has not been reported.
Mohs Micrographic Surgery for Advanced Centrofacial Tumors
Authors: Norris Ivy I. , Weinberger Christine H. , Holmes Todd E. , Goldman Glenn D. 
Published: November 2019

BACKGROUND
Mohs surgery was developed for the treatment of advanced skin cancers. Advanced centrofacial tumors are among the most challenging lesions.

OBJECTIVE
The objective of the study was to review the most complex midface cases from our practice and to delineate how to plan the approach to these lesions, how to remove them in a step-by-step fashion, and how the patients were managed in a multidisciplinary manner when indicated.

METHODS
We reviewed 15 years of the most complex tumors to present to our practice for which Mohs micrographic surgery was performed. Follow-up for patients ranged from 3 to 13 years and is ongoing.

RESULTS
Twenty cases were identified in which tumors of the central face extended to bone and created extensive operative wounds. Eleven lesions were recurrent at presentation, and 9 had perineural disease. These cases are reviewed sequentially and demonstrate the challenges, successes, and pitfalls of Mohs micrographic surgery in the treatment of the most difficult tumors. Two patients died from disease.

CONCLUSION
Mohs surgery is an excellent technique for the removal of extensive midfacial lesions and allows for the surgical removal of lesions that might otherwise be considered inoperable. Approach to these lesions requires careful planning, meticulous surgical technique, excellence in histology, and an experienced reconstructive surgeon. Such tumors often require a multidisciplinary approach, imaging, and adjuvant therapy. All such cases require diligent follow-up. Although many such lesions will be cured, regional recurrence and metastasis may result, even when clear margins are achieved.
Outcomes of Mohs Micrographic Surgery at the American Society for Dermatologic Surgery International Traveling Mentorship Program International Mohs Fellowship Recognition Units: A Retrospective Survey of 5889 Cases From South Africa, Romania, and the Netherlands
Authors: du Plessis Pieter J. , Leventer Mihaela , Krekels Gertruud , de Wet Jacob D. , Laeuchli Severin 
Published: November 2019

BACKGROUND
The American Society for Dermatologic Surgery (ASDS) International Traveling Mentorship Program (ITMP) has initiated an International Mohs Fellowship Recognition Program, with 3 centers accredited to date.

OBJECTIVE
To describe and compare the outcomes of Mohs micrographic surgery (MMS) at the three units.

METHODS
From patient files, we extracted demographic information, as well as tumor type, location of tumor, tumor histology, stages of MMS, and outcomes.

RESULTS
At the 3 units, 3,899 patients were treated with MMS over a 5-year period in the South African unit, and 1,141 cases in the Romanian unit. Over a 3-year period, 849 cases were treated in the Netherlands unit. Basal cell carcinomas (BCCs) constituted 78.9% (South African unit), 79% (Romanian unit), and 97.2% (Netherlands unit), and squamous cell carcinomas (SCCs) 17.7% (South African unit), 19% (Romanian unit), and 0.7% (Netherlands unit) of the tumors treated. The recurrence rate following MMS was low, at 0.1% (South African Unit) and 0.17% (Romanian Unit) of cases at the end of the study period, with a median follow-up time of 2 years.

CONCLUSION
Mohs micrographic surgery is an effective treatment modality for removing BCC and SCC at ASDS ITMP–recognized International Mohs Fellowship units.
Multidisciplinary Tumor Boards in Dermatologic Surgery
Authors: Chen David L. , Cintolo-Gonzalez Jessica , Cook Deborah , Devenney Brent , Goldman Glenn D. , Greene Laura , Harlow Seth , Holmes Todd , Rehman Hibba , Sajisevi Mirabelle , Anker Chris 
Published: November 2019

BACKGROUND
Recent advances in diagnostic and therapeutic modalities have made oncologic care ever more challenging, and multidisciplinary tumor boards (MTBs) are increasingly being used as a forum to discuss and coordinate care for complex oncology patients. Literature on the use of MTBs specific to cutaneous oncology and dermatologic surgery remains limited.

OBJECTIVE
To share our experiences with cutaneous oncology MTBs at the University of Vermont Medical Center (UVMMC).

METHODS
We describe the formation, timing, participation, clinical discussion, case follow-up, and coordination of care of our MTBs.

RESULTS
A log of all cases discussed at cutaneous oncology MTBs from August 2018 to August 2019 is presented as an example. Five specific cases are described in further detail to demonstrate critical components of multidisciplinary care.

CONCLUSION
The MTBs at UVMMC has created a collaborative environment for providers in multiple specialties to jointly formulate and coordinate optimal treatment plans for difficult cases, particularly when treatment guidelines do not exist or are insufficient. Furthermore, MTBs can serve as an educational forum for all participants.
Embracing and Advancing the Consumerist Era in Healthcare
Authors: Taylor Kay 
Published: November 2019

SUMMARY
The advent of consumerism—especially increasing demands for data, convenience, and transparency—has emboldened and empowered individuals to expect a consumer-centric experience in every aspect of their lives. The Amazon Prime consumer model has instilled an expectation that every transaction should be friction free, with no exception made for healthcare. Indeed, amid the myriad changes in healthcare in recent years, consumerism is making a pronounced impact on every aspect of healthcare delivery.
EvergreenHealth, an integrated two-hospital healthcare system based in Kirkland, Washington, is addressing the demands of its patient-consumers. We serve nearly 1 million residents at a 318-bed medical center and four medical specialty buildings in Kirkland and a 72-bed hospital in Monroe, Washington. In addition, our 350-member physician multispecialty group encompasses 13 primary care clinics, 5 urgent care clinics, 3 emergency departments, and 26 specialty care practices. EvergreenHealth has been named one of America’s 100 Best Hospitals by Healthgrades for three consecutive years (2017–2019), and we earned Healthgrades’ Outstanding Patient Experience Award in 2018. In providing an exceptional patient experience, we are seeing that the patient’s new role as consumer is an accelerating trend that will continue to drive change and force all health systems to adopt new ways of operating.
In fact, I believe that those health systems that embrace the consumerist era of healthcare by investing and innovating in ways that meet patient-consumer needs will remain viable even as sentiments shift, technology evolves, and new threats emerge. In contrast, those that do not heed the consumer’s clarion call are in for difficult times.
RANIBIZUMAB TREATMENT IN TREATMENT-NAIVE NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
Authors: Holz Frank G. , Figueroa Marta S. , Bandello Francesco , Yang Yit , Ohji Masahito , Dai Hong , Wykrota Halina , Sharma Sanjay , Dunger-Baldauf Cornelia , Lacey Sue , Macfadden Wayne , Mitchell Paul ,   on behalf of all the LUMINOUS study investigators
Published: November 2019

Purpose:
To evaluate the effectiveness, safety, and treatment patterns of ranibizumab 0.5 mg in treatment-naive patients with neovascular age-related macular degeneration enrolled in LUMINOUS study.

Methods:
This 5-year, prospective, multicenter, observational study recruited 30,138 adult patients (treatment-naive or previously treated with ranibizumab or other ocular treatments) who were treated according to the local ranibizumab label.

Results:
Six thousand two hundred and forty-one treatment-naive neovascular age-related macular degeneration patients were recruited. Baseline (BL) demographics were, mean (SD) age 75.0 (10.2) years, 54.9% females, and 66.5% Caucasian. The mean (SD) visual acuity (VA; letters) gain at 1 year was 3.1 (16.51) (n = 3,379; BLVA, 51.9 letters [Snellen: 20/92]) with a mean (SD) of 5.0 (2.7) injections and 8.8 (3.3) monitoring visits. Presented by injection frequencies <3 (n = 537), 3 to 6 (n = 1,924), and >6 (n = 918), visual acuity gains were 1.6 (14.93), 3.3 (16.57), and 3.7 (17.21) letters, respectively. Stratified by BLVA <23 (n = 382), 23 to <39 (n = 559), 39 to <60 (n = 929), 60 to <74 (n = 994), and ≥74 (n = 515), visual acuity change was 12.6 (20.63), 6.7 (17.88), 3.6 (16.41), 0.3 (13.83), and −3.0 (11.82) letters, respectively. The incidence of ocular/nonocular adverse events was 8.2%/12.8% and serious adverse events were 0.9%/7.4%, respectively.

Conclusion:
These results demonstrate the effectiveness and safety of ranibizumab in treatment-naive neovascular age-related macular degeneration patients.
Efficacy and Safety of Intense Pulsed Light in Patients With Meibomian Gland Dysfunction—A Randomized, Double-Masked, Sham-Controlled Clinical Trial
Authors: Piyacomn Yonrawee , Kasetsuwan Ngamjit , Reinprayoon Usanee , Satitpitakul Vannarut , Tesapirat Lita 
Published: November 2019

Purpose:
To study the efficacy and safety of intense pulsed light (IPL) in patients with meibomian gland dysfunction (MGD).

Methods:
This prospective randomized double-masked sham-controlled trial included 114 patients with MGD. Patients were randomized into the IPL or sham group. Either the IPL or sham procedure was performed on days 0, 15, and 45. Ocular Surface Disease Index (OSDI), visual analog scale, visual acuity, tear breakup time, meibum quality and expressibility, meibography grade, ocular surface staining, tear film lipid layer thickness, tear osmolarity, Schirmer test, tear interleukin-1 receptor agonist, and interleukin-6 levels were examined on days 0, 15, and 45 and at months 3 and 6. Subgroup analysis according to stage and the patient's compliance to conventional treatment were also analyzed. Any adverse events during the study were recorded. A multilevel mixed-effect linear regression model was used. P value less than 0.05 was considered statistically significant.

Results:
At 6 months, tear breakup time, meibum quality grades, expressibility grades, and OSDI were better in the IPL group (5.23 ± 2.91 vs. 3.11 ± 0.99 seconds, P < 0.001; 8.74 ± 4.74 vs. 13.19 ± 5.01, P < 0.001; 0.50 ± 0.67 vs. 1.12 ± 0.70, P < 0.001; 24.29 ± 16.92 vs. 32.71 ± 20.07, P < 0.05). OSDI, meibum quality, and expressibility in the IPL group began to improve at day 15 (P < 0.001), whereas the results in the sham group began to improve at day 45 (P < 0001). No adverse event occurred after IPL.

Conclusions:
IPL is effective and safe for MGD treatment in all stages regardless of compliance.
Risk Factors for the Development of Ocular Hypertension After Keratoplasty: A Systematic Review
Authors: Liesenborghs Ilona , Schouten Johannes S. A. G. , Berendschot Tos T. J. M. , Beckers Henny J. M. , Nuijts Rudy M. M. A. , Visser Nienke , Webers Carroll A. B. 
Published: November 2019

Purpose:
To identify risk factors for the development of ocular hypertension after keratoplasty.

Methods:
A systematic search in PubMed and Embase identified 67 relevant articles published between January 1990 and 2019. We preferentially searched for data on an intraocular pressure increase above 21 mmHg at 6 months or a threshold or time point close to that and reported whether the preoperative or intraoperative status of risk factors was defined. The results were presented in evidence tables, visualizing the direction of the association, whether univariate and/or multivariate analysis was performed, and the significance level (P < 0.05). Four researchers, blinded for the risk factors, independently assigned a level of evidence (definitely, probably, possibly, not associated). Consensus was met during group meetings.

Results:
From the 110 studied risk factors, pre-existing glaucoma, high preoperative IOP and combined keratoplasty with removal or exchange of an intraocular lens (IOL) were definitely associated with an increased risk. In addition, if the pre-or postoperative lens status was undefined, aphakia and pseudophakia with the IOL in the anterior or posterior chamber were also definitely associated with an increased risk when compared to phakia. Glaucoma in the contralateral eye, indication of bullous keratopathy, African American descent, preoperative treatment with cyclosporine or olopatadine 0.1%, postoperative treatment with prednisolone acetate 1%, and combined surgery in general (ie, the type of surgeries undefined in primary studies) were probably associated. Multiple other identified risk factors lack sufficient evidence and need additional investigation.

Conclusions:
Risk factors with a definite association can help clinicians select patients at risk and adjust their follow-up and treatment. The other factors need further investigation.
Sexual Assault Reporting and Emotional Distress Among College Female-Identified Victims/Survivors
Authors: Eisenberg Marla E. , Palacios Lena , Lust Katherine , Porta Carolyn M. 
Published: November 2019

ABSTRACT

Purpose
The current study tests associations between reporting sexual victimization to a healthcare provider, campus authority, police, or social contact, and emotional well-being among college women.

Methods
Data from 2,162 women who participated in the 2015 College Student Health Survey at 17 colleges in Minnesota was used. Analyses tested associations between reporting sexual assault to formal or informal resources and diagnosis with anxiety, depression, panic attacks, and posttraumatic stress disorder, as well as self-rated health.

Results
Significantly higher rates of all four diagnoses were observed among those who reported to formal resources (e.g., healthcare provider, police) compared with those who reported to informal resources (i.e., friends, family). However, no differences were seen in self-rated physical or mental health.

Conclusions
Expansion of trauma-informed healthcare services and advocacy efforts is recommended to optimally support students who report sexual assault experiences.
A Systematic Review on Implementing Education and Training on Trauma-Informed Care to Nurses in Forensic Mental Health Settings
Authors: Maguire Donna , Taylor James 
Published: November 2019

ABSTRACT

Background:
Engaging in trauma-informed approaches in nonforensic mental health settings improves therapeutic relationships, promotes healing, promotes posttraumatic growth, improves staff well-being, and fosters hope and empowerment, yet little is known of its influences in forensic settings. This literature review explores trauma-informed education and its training implications for nurses working in forensic mental health.

Method:
Using a range of electronic databases, a systematic search of literature was carried out focusing on trauma-informed practice in adult forensic mental health settings. Before searching, predefined inclusion and exclusion criteria were agreed.

Findings:
After duplication removal, abstract review, and full screening, nine articles met review criteria for inclusion. A thematic analysis of the literature identified two key themes: “education for trauma-informed practice” and “applying theory into practice.” Each had several subordinate themes.

Implications for Forensic Practice:
Organizations and their staff must recognize that operational change and ongoing training will be required. By adopting a trauma-informed approach, forensic mental health nurses can better understand their patients' traumatic experiences, improve their therapeutic relationships, and engage patients in collaborative care. Training in trauma-informed care should start with nurses who will change their personal practice and can support and train their colleagues.
Effect of Socioeconomic Factors on the Relationship Between Musculoskeletal Pain and Ill-Health Retirement in Korea
Authors: Lee Seyoung , Yoon Jin-Ha , Kang Young Joong , Kim Taeshik , Koo Jung-Wan , Kang Mo-Yeol 
Published: November 2019

Objective:
To investigate the relationship between musculoskeletal pain (MSP) and ill-health retirement (IHR) and modifying role of socioeconomic factors.

Methods:
The data used were samples from the Korean Longitudinal Study of Aging from 2006 to 2014. IHR was defined as retirement due to health problems before regular retirement age. Hazard ratio (HR) was calculated using Cox proportional hazards model to determine the effects of MSP and covariance on IHR.

Results:
People who have “any site of pain” were more likely to experience IHR than people with no pain. In the subgroup analysis, risk of IHR due to MSP was higher in the 60s, white-collar, and high-income earners than the other groups.

Conclusions:
MSP has a substantial negative impact on labor force participation, and there was a clear effect modification of socioeconomic status on IHR risk.