bluuebunny/crossref_metadata_2025_split huggingface dataset:
The transfer of knowledge on integrated care among five European regions: a qualitative multi-method study
Authors: Grooten Liset , Vrijhoef Hubertus Johannes Maria , Alhambra-Borrás Tamara , Whitehouse Diane , Devroey Dirk 
Published: December 2019

Abstract
Background To examine how the knowledge transfer processes unfolded within SCIROCCO, a EU funded project (3rd Health Programme (2014-2020)) that aimed to facilitate the process of knowledge sharing across five European regions, to speed up adoption and scaling-up of integrated care initiatives. Methods A qualitative multi-method design was used. Data collection methods included focus groups, project documents and action plans of the regions. The data was analysed using a qualitative content-analysis procedure, which was guided by the frameworks of knowledge exchange and the why, whose, what, how framework for knowledge mobilisers Results All five components (including the themes) of knowledge exchange could be identified in the approach developed on the knowledge transfer processes. The four questions and accompanying categories of the framework of knowledge mobilisation were also identified to a large degree. Conclusions The observed incorporation of distinct forms of knowledge from multiple sources and the observed dynamic and fluid knowledge transfer processes both suggest that SCIROCCO developed a comprehensive knowledge transfer approach aiming to enable the adoption and scaling-up of integrated care. Overall, the multi-method qualitative nature of this research has allowed some new and practical insights in the knowledge transfer activities on integrated care between several European regions. To obtain a clear understanding of the content of the knowledge transfer approaches, which could assist the operationalising of models to support the evaluation of knowledge transfer activities, it is strongly recommended that further research of this type should be conducted in other research settings.
Clinical evaluation of ultrasonic subgingival debridement versus ultrasonic subgingival scaling combined with manual root planing in the treatment of periodontitis: study protocol for a randomized controlled trial
Authors: Yan Yue , Zhan Yalin , Wang Xian'e , Hou Jianxia 
Published: December 2019

Abstract
Background: Periodontal diseases are regarded as the most common diseases of mankind. The prevalence rate of periodontal disease assumes the obvious growth tendency in the whole world, increased by 57.3% from 1990 to 2010. Thereby, effective periodontal therapy is still a long-term task and tricky problem. The goals of periodontal therapy are to eliminate the infectious and inflammatory processes. Root planing, in order to eliminate the “infected cementum”, is an important step in treatment of periodontitis since 1970s. Along with the understanding of endotoxin’s feature on root surface, the necessity of manual root planing has been gradually queried. Ultrasonic instruments wouldn’t remove the cementum excessively, which are more time-saving and labor-saving compared to hand instruments as well. Hence, an increasing number of dentists prefer to scaling with ultrasonic instruments only. However, the necessity of root planing has still been emphasized in the international mainstream views of periodontal mechanical treatment. Therefore, this study is devoted to compare the clinical effect of ultrasonic subgingival debridement and ultrasonic subgingival scaling combined with manual root planing, which taking the implementation of root planing as the only variable and more in line with the clinical situation, hoping to provide some reference to dentists. Methods/design: Forty adult patients who fit the inclusion criteria are being recruited from the Peking University Hospital of Stomatology (Beijing, China). By means of randomization tables, one quadrant of the upper and lower teeth is the test group and the other is the control group. Test group: ultrasonic subgingival scaling combined with manual root planing. Control group: ultrasonic subgingival debridement. In a 24-weeks follow-up period, plaque index, probing depth, clinical attachment loss, bleeding index, furcation involvement, mobility, and patient-reported outcome (visual analog scale for pain and sensitivity) will be observed and documented. Discussion: This study evaluates the effectiveness of ultrasonic subgingival scaling combined with manual root planing and ultrasonic subgingival debridement alone in nonsurgical treatment of periodontitis with a split-mouth design after 1, 3 and 6 months. The result of the trial will potentially contribute to an advanced treatment strategy of periodontitis with ideal clinical outcome. Trial registration: The study has been registered in International Clinical Trials Registry Platform (ICTRP) under the identifier number ChiCTR1800017122. Registered on 12 July 2018. Keywords: Peridontitis, Non-surgical periodontal therapy, Ultrasonic subgingival debridement, Root planing
Developing an experimental necrotic enteritis model in turkeys - the impact of Clostridium perfringens, Eimeria meleagrimitis and host age on frequency of severe intestinal lesions
Authors: Hardy Simon P. , Benestad Sylvie L. , Hamnes Inger Sofie , Moldal Torfinn , David Bruce , Barta John R. , Reperant Jean-Michel , Kaldhusdal Magne 
Published: December 2019

Abstract
Background: Necrotic enteritis is a significant problem to the poultry industry globally and, in Norway up to 30 % of Norwegian turkey grow-outs can be affected. However, despite an awareness that differences exist between necrotic enteritis in chickens and turkeys, little information exists concerning the pathogenesis, immunity, microbiota or experimental reproduction of necrotic enteritis in turkeys. In particular, it is important to determine the appearance of the gross lesions, the age dependency of the disease and the role of netB toxin of Clostridium perfringens . To this end, we report our findings in developing an in vivo experimental model of necrotic enteritis in turkeys. Results: A four tier (0-3) scoring system with clearly defined degrees of severity of macroscopic intestinal lesions was developed, based on 2312 photographic images of opened intestines from 810 B.U.T. 10 or B.U.T. Premium turkeys examined in nine experiments. Loss of macroscopically recognizable villi in the anterior small intestine was established as the defining lesion qualifying for a score 3 (severe intestinal lesions). The developed scoring system was used to identify important factors in promoting high frequencies of turkeys with severe lesions: a combined Eimeria meleagrimitis and Clostridium perfringens challenge, challenge at five rather than three weeks of age, the use of an Eimeria meleagrimitis dose level of at least 5 000 oocysts per bird and finally, examination of the intestines of 5-week-old turkeys at 125 to 145 hours after Eimeria meleagrimitis inoculation. Numbers of oocysts excreted were not influenced by Clostridium perfringens inoculation or turkey age. Among three different lesion score outcomes tested, frequency of severe lesions proved superior in discriminating between impact of four combinations of Clostridium perfringens inoculation and turkey age at challenge. Conclusions: This study provides details for the successful establishment of an in vivo model of necrotic enteritis in turkeys.
Methicillin-resistant Staphylococcus aureus in veterinary professionals in 2017 in the Czech Republic
Authors: Neradova Katerina , Jakubu Vladislav , Pomorska Katarina , Zemlickova Helena 
Published: December 2019

Abstract
Background Cases of colonization or infection caused by Methicillin-resistant Staphylococcus aureus (MRSA) are frequently reported in people who work with animals, including veterinary personnel. The aim of this study was to determine the prevalence of MRSA colonization among veterinary professionals. A total of 134 nasal swabs from healthy attendees of a veterinary conference held in the Czech Republic were tested for presence of MRSA. The stains were further genotypically and phenotypically characterized. Results Nine isolated MRSA strains were characterized with sequence type (ST), spa type (t) and Staphylococcal Cassette Chromosome mec type. Five different genotypes were described, including ST398-t011-IV (n=5), ST398-t2330-IV (n=1), ST398-t034-V (n=1), ST225-t003-II (n=1) and ST4894-t011-IV (n=1). The carriage of the animal MRSA strain was confirmed in 8 cases, characteristics of one strain corresponded to the possible nosocomial origin. Among animal strains were described three spa types (t011, t034, t2330) belonging into one dominating clonal complex CC11. Conclusion According to our results, the prevalence of nasal carriage of MRSA in veterinary personnel is 6.72%. Although we described an increase compared to the results of previous study (year 2008), the prevalence in the Czech Republic is still remaining lower than reported from neighboring countries. Our results also indicate that healthcare - associated MRSA strains are still not spread among animals.
Multistability in the epithelial-mesenchymal transition network
Authors: Xin Ying , Cummins Breshine , Gedeon Tomas 
Published: December 2019

Abstract
Background: The transitions between epithelial (E) and mesenchymal (M) cell phenotypes are essential in many biological processes like tissue development and cancer metastasis. previous studies, both modeling and experimental, suggested that in addition to E and M states, the network responsible for these phenotypes exhibits intermediate phenotypes between E and M states. The number and importance of such states is subject to intense discussion in the epithelial-mesenchymal transition (EMT) community. Results: Previous modeling eorts used traditional bifurcation analysis to explore the number of the steady states that correspond to E, M and intermediate states by varying one or two parameters at a time. Since the system has dozens of parameters that are largely unknown, it remains a challenging problem to fully describe the potential set of states and their relationship across all parameters. We use the computational tool DSGRN (Dynamic Signatures Generated by Regulatory Networks) to explore the intermediate states of an EMT model network by computing summaries of the dynamics across all of parameter space. We nd that the only attractors in the system are equilibria, that E and M states dominate across parameter space, but that bistability and multistability are common. Even at extreme levels of some of the known inducers of the transition, there is a certain proportion of the parameter space at which an E or an M state co-exists with other stable steady states. Conclusions: Our results suggest that the multistability is broadly present in the EMT network across parameters and thus response of cells to signals may strongly depend on the particular cell line and genetic background. Keywords: Epithelial-Mesenchymal transition; multistability; network models
A bibliometric analysis of systematic review/meta-analysis on dry eye disease
Authors: Zhang Yonggang , Ping An , Lyu Shuyuan 
Published: December 2019

Abstract
Background There was no citation analysis about systematic review/meta-analysis published on dry eye disease (DED). The objective of this study was to identify the citations of systematic review/meta-analysis published on DED and to provide information on the achievement and development of evidence-based dry eye research.Methods Web of Knowledge Core Collection was searched for all systematic review/meta-analysis relevant to DED. The number of citations, authorship, year, journal, country, and institution were analyzed for each study.Results A total of 29 systematic reviews/meta-analyses on DED published between 2009 and 2017 were included. The number of citations ranged from 0 to 63, with a medium of 8 citations. These systematic reviews/meta-analyses were from 10 countries, and 15 of them were from China. They were published in 21 journals. Ocular Surface published most studies (n =4), followed by International Journal of Ophthalmology (n =3). The journal with highest impact factor was Nutrition Reviews (IF=5.291 in 2016).Conclusion The citations of systematic reviews/meta-analyses on DED are still low. Further systematic reviews/meta-analyses are needed for providing more evidence for DED.
Experiences of women accessing family planning services in Malawi: A Grounded Theory Study
Authors: Chilinda Idesi Temwa , Cooke Alison , Lavender Dame Tina 
Published: December 2019

Abstract
Background The importance of modern contraceptive methods in averting unwanted pregnancies has been acknowledged in Malawi. Currently, the country has registered highest rates of unsafe abortions, slow decline in maternal mortality, unmet needs for contraception and a low contraceptive prevalence rate. Understanding why these rates exist is important. However, women’s views and experiences regarding uptake of family planning methods in Malawi have not been explored.Methods A grounded theory methodology was used. Data were gathered through in-depth interviews with women (n=18), men (n=10), healthcare workers (n=10); and non-participant observations of family planning clinic consultations (n=10) at three health centre settings in Malawi. Interviews, field notes and memos were analysed using constant comparative technique. Methods of open, axial and selective coding enabled subsequent conceptualisations until theoretical saturation occurred.Results The core category “disenabling environment prevents women’s family planning needs from being met” provides an understanding of women’s, men’s and healthcare workers’ experiences of contraceptive use and non-use. The disenabling environment contributed to shaping women’s family planning experiences. This was supported by three main categories: navigating the processes, disempowerment of women and learning by chance. Access to contraception use was influenced by personal beliefs and motivations, procedures to follow and inadequate resources. Women were disempowered from using contraception due to societal demands and cultural influences.Conclusion Findings from this study illuminate contextual issues into how women, men and healthcare workers experience family planning use and non-use in Malawi. A multifaceted strategy is required to support a woman’s family planning needs. At community level, awareness and education of family planning methods is required to actively inform all people in society so that they support a woman’s family planning needs. At national level, laws that would empower women with decision-making ought to be developed and enforced.
Prevalence of shisha smoking and risk factors among female adolescents in Iran
Authors: Bashirian Saeed , Barati Majid , Karami Manoochehr , Hamzeh Behrooz , ezati elahe 
Published: December 2019

Abstract
Background: shisha smoking is on the increase in Iarn, but there are limited data on its use among adolescents. This research purpose is to the survey prevalence of shisha smoking and risk factors among female in Iran. Methods: This was a cross-sectional study . The study participants was 1302. The sampling was multistage random. 12 schools from three sectors of Kermanshah in the western city in Iran( 4 schools from each sector), were selected. Students were in grades 7 to 12. data were collected using questionnaire and analyzed by descriptive statistical methods and Logistic regression test by using SPSS 22 software. Results: The mean (SD) ages of the students and the ages when the participants started SS were 15.22 ± 1.85 and 13.64 (1.64) respectively. 32.4% of the participants ever having used a shisha and 20.4% mentioned they used shisha the last 30 days. Most of the subjects smoked shishas in friends’ houses (45.8%) and with their friends (47.4%). The significantly important factors that affect SS in these age groups were the father's and mother's occupation, family size, living with others, father's education, having a friend who smokes shishas, friends’ encouragement to smoke shisha, and being in a family that smoke shishas. Conclusions: shisha smoking has become a major concern in female . shisha prevention needs extensive studies. Investigation of shisha behavioral factors is essential in designing of educational interventions. Key words: Female, adolescents, student, shisha smoking .
Social participation needs of older adults living in a rural area: Toward reducing situations of isolation and vulnerability
Authors: Levasseur Melanie , Routhier Sonia , Clapperton Irma , Doré Chantal , Gallagher Frances 
Published: December 2019

Abstract
Background: Social participation is critical in fostering community vitality, promoting health, and preventing disabilities, but is restricted for approximately half the older adult population. Social participation involves social and leisure activities, such as visiting friends, bowling, etc., that meet fundamental needs for interaction, well-being and self-actualization. Although targeted through interventions by community organizations, healthcare professionals and municipalities, little is known about the needs of older adults to participate socially, especially in rural areas. This study thus aimed to identify and prioritize the social participation needs of older adults living in a rural area. Methods: A participatory action research was conducted in a rural regional county municipality (RCM) in Quebec, Canada with convenience sample of 139 stakeholders, including older adults, caregivers, healthcare and community organization managers, healthcare and community organization workers, RCM partners and key informants. Results: Facilitators and barriers to social participation related to personal factors (e.g., health, interests, motivation), the social environment (e.g., availability of assistance or volunteers) and the physical environment (e.g., distance to resources, recreational facilities and social partners). Nine needs emerged and were prioritized as follows: 1) having access to and being informed about transportation options, 2) being informed about available activities and services, 3) having access to activities, including volunteering opportunities, suited to their interests, schedule, cost, language and health condition, 4) being accompanied to activities, 5) having access to meeting places near home and adapted to their health condition, and 6-9 (no preferred order) being reached when isolated, being personally invited and welcomed to activities, having a social support network, and being valued and recognized. Differences emerged when prioritizing needs of older adults with disabilities (greater need for assistance, accessibility and adapted activities) and older adults living in a rural area (greater need for transportation).Conclusions: To promote active participation in the community, the social participation needs of older women and men living in rural areas must be addressed, especially in regard to transportation, information, adapted activities, assistance and accessibility. The first part of this action research will be followed by community selection and implementation of initiatives to ultimately foster their social participation.
The relationship between Hyperuricemia and Contrast-induced acute kidney injury undergoing primary percutaneous coronary intervention: the protocol of secondary analysis for ATTEMPT RESCIND-1 study
Authors: Guo Wei , Song Feier , Chen Shiqun , Zhang Li , Sun Guoli , Liu Jin , Chen Jiyan , Liu Yong , Tan Ning 
Published: December 2019

Abstract
Background: Contrast-induced acute kidney injury (CI-AKI) contributes toward unfavorable clinical outcomes after primary percutaneous coronary intervention (pPCI). We assessed whether hyperuricemia is an independent predictor of CI-AKI and outcomes in patients undergoing pPCI. Methods/design: Our study was a secondary analysis for the database from ATTEMPT study, enrolling 560 ST-segment elevation myocardial infarction (STEMI) patients undergoing pPCI. Eligible patients received peri-procedural either via aggressive (left ventricular end-diastolic pressure guided) or routine (<=500ml) intravenous hydration with the isotonic solution (0.9% NaCl) with randomization. The primary endpoint was CI-AKI, defined as >25% or 0.5 mg/dL increase in serum creatinine from baseline during the first 48-72 hours post-procedurally. Patients were divided into 2 groups according to the admission serum uric acid (SUA) level. Hyperuricemia was defined as a SUA level >7 mg/dL (417 mmol/L) in males and >6 mg/dL (357 mmol/L) in females. Multivariate analyses for CI-AKI and long-term mortality were performed using the logistic regression and Cox regression analyses, respectively. Discussion: This study will determine the predictive value of hyperuricemia for the development of CI-AKI and outcomes in patients with STEMI undergoing pPCI. We predict that hyperuricemia will be associated with a risk of CI-AKI in patients with pPCI. Furthermore, after adjusting for other variables, long-term mortality after pPCI was higher in those with hyperuricemia than in those with normouricemia. Results of this study may provide scientific evidence for the effect of hyperuricemia on CI-AKI and long-term outcomes, thereby offering the potential possibility of lowering SUA on the development of CI-AKI and outcomes.
PULMONER HİPERTANSİYONLU BİREYLERDE KİNEZYOFOBİ
Authors: ERTAN Özge , KURAN ASLAN Gökşen , AKINCI Buket , OKUMUŞ Nigar Gülfer 
Published: December 2019

Amaç: Bu çalışmanın amacı pulmoner hipertansiyonlu (PH) bireylerde kinezyofobinin egzersiz
kapasitesi, günlük yaşam aktiviteleri (GYA) ve yaşam kalitesi ile ilişkisini araştırmak ve demografik
ve klinik özelliklere göre karşılaştırmaktı.
Yöntem: Çalışmaya 37 PH’li hasta dahil edildi. Kinezyofobi değerlendirmesi, Kalp İçin Tampa
Kinezyofobi Derecelendirmesi (KTKD) ile yapıldı. Yaşam kalitesi, Nottingham Sağlık Profili (NSP)
ile belirlendi. Günlük yaşam aktiviteleri, London Chest Günlük Yaşam Aktiviteleri Ölçeği (LCGYAÖ)
ile değerlendirildi. Egzersiz kapasitesi, altı dakika yürüme testi (6DYT) ile ölçüldü ve 6DYT mesafesi
hesaplandı.
Sonuçlar: KTKD toplam skor, 6DYT sonrası dispne algılaması (p=0,016), NSP toplam skoru
(p=0,024), NSP alt gruplarından emosyonel reaksiyonlar (p0,05). Çoklu doğrusal regresyon analizinde;
dispne algılaması (p=0,006) ve emosyonel reaksiyonların (p
AYAK BİLEĞİ EKİN DEFORMİTESİ OLAN TİP 2 DİYABET HASTALARINDA GERME EGZERSİZİNİN AYAK TABAN BASINCINA AKUT ETKİSİ
Authors: YURT Yasin , MIHÇIOĞLU Serpil , MALKOÇ Mehtap , UZUNER Selma , SEZEREL Buse , TOMAÇ Hayriye 
Published: December 2019

Amaç: Plantar fleksör kısalığına bağlı olarak gelişen ayak bileği ekin deformitesinin, tip 2 diyabeti
olan bireylerde ön ayak taban basıncını artırarak ülser oluşumuna neden olduğu bilinmektedir.
Amacımız ayak bileği ekin deformitesi olan tip 2 diyabetli bireylerde germe egzersizinin ayak taban
basıncına akut etkisini incelemekti.
Yöntem: Ayak bileği ekin deformitesi olan toplam 25 tip 2 diyabetli birey araştırmaya dahil edildi.
Bireylerin 21’i bilateral ve dördü unilateral ekin deformitesine sahip olduğu için, toplam 46 ayak
analiz edildi. Ekin deformitesi, diz ekstansiyonda iken ayak bileğinin 0°’den az dorsifleksiyonu olarak
tanımlandı. Ayak taban basıncı ölçümü için pedobarografik platform kullanıldı ve ayak tabanı 10
bölgeye ayrılarak tepe plantar basınç değerleri hesaplandı. Duvar kenarında 10 tekrarlı yapılan
plantar fleksör germe egzersizi öncesinde, hemen sonrasında ve aradan bir saat geçtikten sonra
aynı ölçüm tekrarlandı.
Sonuçlar: Germe egzersizinin hemen sonrasında yapılan ölçümlerde, dördüncü metatars bölgesi
hariç tüm metatars başlarında tepe plantar basınç azaldı (p0,05).
Tartışma: Plantar fleksör kısalığı bulunan tip 2 diyabetlilerde tek setlik germe egzersizi ile ön ayak
taban basıncı kısa süreli olarak azalmaktadır. Plantar fleksörlerin esnekliğinin uzun süreli egzersiz
programları ile artırılması diyabetiklerde artmış olan ön ayak ülserleri riskini azaltabilir.