bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase I non-linear profiles monitoring using a modified Hausdorff distance algorithm and clustering analysis
Authors: Nie Bin , Liu Diqing , Liu Xiaohui , Ye Wenjing 
Published: July 2020

PurposeThe purpose of this paper is to propose a new non-parametric phase I control chart for the problem of non-linear profile outlier detection.Design/methodology/approachThe proposed non-parametric method is based on a modified Hausdorff distance, which does not require a restrictive assumption on the form of profiles. By obtaining the distance between each profile and the baseline profile, the authors introduced an iterative optimization clustering algorithm to identify outliers by clustering distances.FindingsThe simulation results show that the proposed method can distinguish outliers for structural changes of non-linear profiles. The authors also present a real industrial case example to highlight how practitioners can implement and make use of the proposed control chart in outlier detection applications, and it achieves higher accuracy in the outlier detection of complex profiles.Practical implicationsThe research results of this paper can be applied to any manufacturing or service system whose quality characteristics are characterized by non-linear profiles. This new approach provides quality practitioners a better decision-making tool for non-linear profile outlier detection.Originality/valueDue to the complexity of real-world applications, the non-linear profiles monitoring problem is yet to be addressed. However, the related research still remains rare. And the authors’ proposed non-linear profile control chart, which does not require a restrictive assumption on the form of profiles, shows its applicability and superiority in simulation study and real-world case.
An instrument validation of TQM enablers and IT resources in Indian ICT organizations
Authors: Khanam Suby , Talib Faisal , Siddiqui Jamshed 
Published: July 2020

Purpose
The purpose of this study is to identify and rank total quality management (TQM) enablers and information technology (IT) resources to provide a reliable and valid measurement instrument for evaluation in Indian information and communications technology (ICT) organizations.

Design/methodology/approach
Based on a literature review of TQM enablers and IT resources, 17 factors are identified, of which, 9 are TQM enablers and 8 are IT resources. The empirical data, retrieved from 801 ICT organizations, is tested by descriptive analysis and factor analysis (FA). FA is used to ensure that items in each scale sufficiently reflect the scope of each factor.

Findings
This paper has developed an instrument that can be used to evaluate items to implement TQM enablers and IT resources. The instrument identifies 17 reliable and valid factors, out of which 16 are input factors, while 1 is an outcome factor.

Practical implications
This instrument will provide a practical understanding to enable the monitoring of TQM enabler and IT resource activities in ICT organizations. Along with this, these instruments will help to build models related to constructs that will further achievement of customer satisfaction (CS).

Originality/value
This paper presents an instrument which validates the different items of TQM enablers and IT resources. It also shows the relationship between the two in terms of CS.
The urgent need for microbiology literacy in society: children as educators
Authors: Timmis Kenneth , Timmis James , Jebok Franziska 
Published: July 2020

SummaryMicrobes and their activities have pervasive influence and deterministic roles in the functioning and health of the geosphere, atmosphere and biosphere, i.e. in nature. Microbiology can be considered a language of nature. We have argued that the relevance of microbes for everyday personal decisions and collective policies requires that society attains microbiology literacy, through the introduction of child‐relevant microbiology topics into school curricula. That is: children should learn the microbiology language of nature. Children can be effective transmitters of new and/or rapidly evolving knowledge within families and beyond, where there is a substantive information asymmetry (witness digital technology, social media, and new languages in foreign countries). They can thus be key disseminators of microbiology knowledge, where there will be information asymmetry for the foreseeable future, and thereby contribute to the attainment of microbiology literacy in society. The education of family and friends can be encouraged/stimulated by home assignments, family leisure projects, and school‐organised microbiology‐centric social‐education events. Children are key stakeholders in family decisions. Their microbiology knowledge, and their dissemination of it, can help inform and increase the objectivity of such decisions.
Uterocervical angle as a predictor of preterm birth on a high‐risk collective between 20 and 31 weeks of gestation: A cohort analysis
Authors: Gründler Kathleen , Gerber Bernd , Stubert Johannes 
Published: July 2020

AbstractIntroductionThe cervical length (CL) measurement is a widely used method to estimate the risk of preterm birth. Due in particular to the high false‐positive rate, the establishment of markers with improved test characteristics is a great challenge. A potential predictor of preterm birth is the uterocervical angle (UCA) and this additional measurement may improve the risk assessment. It was the aim of this study to compare the test properties of CL and UCA on patients at risk for preterm birth.Material and methods109 patients with at least one of the following signs of threatening preterm birth between 20+0/7 and 31+6/7 weeks were included in a prospective cohort analysis: regular (>3/30 min) or painful uterine contractions, CL below 25 mm or a history of preterm birth. Exclusion criteria were premature rupture of membranes, hypertensive disorders, vaginal bleeding, surgical cerclage, Arabin pessary or cervical dilation of more than 30 mm. The determination of the UCA was carried out in a standardized manner using the image documents captured by vaginal sonographic CL measurement. The primary endpoint was preterm birth <34 weeks, secondary endpoints were delivery <37 weeks and within 7 days.ResultsThe UCA was on average 103° and the mean UCA in preterm and term groups did not differ significantly (P = .924). The UCA was not predictive for threatened preterm birth, even if only singletons were considered. For CL the best predictive accuracy for preterm birth <34 weeks was observed at a cut‐off value of 14 mm with sensitivity 0.50, specificity 0.80, positive predictive value 0.30, negative predictive value 0.90, positive likelihood ratio 2.4, negative likelihood ratio 0.6 and an odds ratio of 3.9 (95% confidence interval 1.3‐11.7, P = .016).ConclusionsThe assessment of UCA in patients at risk for preterm birth was not suitable to predict the probability of a threatened preterm birth. Measurement of UCA cannot be recommended in this situation.
Novel monoclonal antibody against integrin α3 shows therapeutic potential for ovarian cancer
Authors: Ke Feng‐Yi , Chen Wan‐Yu , Lin Ming‐Chieh , Hwang Yu‐Chyi , Kuo Kuan‐Ting , Wu Han‐Chung 
Published: July 2020

AbstractOvarian cancer has a high recurrence rate after platinum‐based chemotherapy. To improve the treatment of ovarian cancer and identify ovarian cancer‐specific antibodies, we immunized mice with the human ovarian carcinoma cell line, SKOV‐3, and generated hybridoma clones. Several rounds of screening yielded 30 monoclonal antibodies (mAbs) with no cross‐reactivity to normal cells. Among these mAbs, OV‐Ab 30‐7 was found to target integrin α3 and upregulate p53 and p21, while stimulating the apoptosis of cancer cells. We further found that binding of integrin α3 by OV‐Ab 30‐7 impaired laminin‐induced focal adhesion kinase phosphorylation. The mAb alone or in combination with carboplatin and paclitaxel inhibited tumor progression and prolonged survival of tumor‐bearing mice. Moreover, immunohistochemical staining of ovarian patient specimens revealed higher levels of integrin α3 in cancer cells compared with normal cells. By querying online clinical databases, we found that elevated ITGA3 expression in ovarian cancer is associated with poor prognosis. Taken together, our data suggest that the novel mAb, OV‐Ab 30‐7, may be considered as a potential therapeutic for ovarian cancer.
Service quality evaluation of satellite data distribution system based on BP‐IPA
Authors: Jin Jiahua , Lu Lu , Yan Xiangbin 
Published: July 2020

AbstractWith the remarkable advances in remote sensing technology, remote sensing data collected by satellites play an important role in many application domains, in particular the smart city. The service quality of satellite data distribution systems (SDDS) is vital for both administrators and end users. Therefore, it is of practical significance to fully understand the factors that affect the satellite data distribution service. Based on prior studies of e‐service quality evaluation and the characteristics of the satellite data, a multidimensional and multi‐level service quality evaluation model of the SDDS is proposed. A questionnaire was designed based on the proposed model to collect users' evaluation data. Backpropagation neural network was employed to examine whether and how factors in the proposed model affect the overall service quality. The results were interpreted using importance and performance analysis to assess the relationship between the keys of service quality of the SDDS and the overall service quality. Findings have important managerial implications for the quality management of the SDDS.
14‐month‐olds exploit verbs’ syntactic contexts to build expectations about novel words
Authors: Babineau Mireille , Shi Rushen , Christophe Anne 
Published: July 2020

AbstractDuring their second year of life, infants develop a rudimentary understanding of grammatical categories based on their knowledge and use of frequent function words. The current study inquired whether, at only 14 months of age, infants can track co‐occurrence patterns between function words and content words (e.g., determiners can precede nouns, and pronouns can precede verbs), and use these previously encountered syntactic contexts to build expectations about which function words can co‐occur with novel words. Using a habituation paradigm, French‐learning 14‐month‐olds were presented with utterances containing two novel words preceded by function words (either two determiners in the Novel Nouns condition or two pronouns in the Novel Verbs conditions). We found that at test, infants looked longer during trials in which the novel words occurred in an unexpected syntactic context (following a pronoun for infants in the Novel Nouns condition and following a determiner for infants in the pooled analysis of the three Novel Verbs conditions). Hence, our results confirm previous findings on infants’ sensitivity to noun contexts and most importantly demonstrate that their sensitivity to the co‐occurrence of verbs with pronouns begins much earlier than previously understood.
Trait evolution and historical biogeography shape assemblages of annual killifish
Authors: Helmstetter Andrew J. , Papadopulos Alexander S. T. , Igea Javier , Van Dooren Tom J. M. 
Published: July 2020

AbstractAimDifferent species assemblages of annual killifish possess replicated body size distributions yet have unique sets of species in each area of endemism. Here, we use models of trait evolution and historical biogeography to discover how size variation originated and has been restructured.LocationSouth America.TaxonAustrolebias (Cyprinodontiformes).MethodsWe sampled 63 individuals from 26 Austrolebias species. Using phylogenetic trees (BEAST2), data on environmental variables at sampling locations and size data, we compare different models for trait evolution (SURFACE, l1OU) of body size and niche traits. We model the historical biogeography of the areas of endemism (BioGeoBEARS) and use both analyses in combination to reconstruct the history of four species assemblages.ResultsWe present new phylogenetic trees for Austrolebias and use them to show that large size principally arose within a single area driven by a shifted selection optimum for a subset of the species in that area. We suggest that ecological interactions triggered size divergence and that this large‐bodied lineage subsequently spread to two other areas. A second assemblage may have been shaped by adaptation to a new environment without an associated increase in size divergence. A third assemblage, which has the smallest size range and the most recent origin, is phylogenetically clustered, and we found no evidence of environmental filtering.Main conclusionsAssemblage similarity in Austrolebias is the result of contrasting ecological, evolutionary and historical processes. Modelling trait evolution together with historical biogeography can help to disentangle the complex histories of multispecies assemblages. This approach provides context to commonly used tests investigating the role of ecological processes from phylogenetic data and generates new testable hypotheses on the processes that generated trait diversity and assemblage similarity.
Characterization of metabolic activity, isozyme contribution and species differences of bavachin, and identification of efflux transporters for bavachin-O-glucuronide in HeLa1A1 cells
Authors: Li Yang , Xu Chunxia , Xu Jinjin , Qin Zifei , Li Shishi , Hu Liufang , Yao Zhihong , Gonzalez Frank J , Yao Xinsheng 
Published: July 2020

Abstract

Objectives
Bavachin is a bioactive natural flavonoid with oestrogen-like activity. Here, we aimed to investigate its metabolic and disposal fates involving in CYPs, UGTs and efflux transporters.

Methods
Phase I metabolism and glucuronidation were performed by human liver microsomes (HLM). Reaction phenotyping and activity correlation analysis were performed to identify the main CYP and UGT isozymes. Chemical inhibition and gene knock-down approaches were employed to explore the function of BCRP and MRPs.

Key findings
Five phase I metabolites (M1–M5) and three glucuronides (G1–G3) were identified. The CLint values for M4 and G1 by HLM were 127.99 and 1159.07 μl/min per mg, respectively. Reaction phenotyping results suggested CYP1A1 (208.85 μl/min per mg) and CYP2C9 (107.51 μl/min per mg), and UGT1A1 (697.19 μl/min per mg), UGT1A7 (535.78 μl/min per mg), UGT1A8 (247.72 μl/min per mg) and UGT1A9 (783.68 μl/min per mg) all participated in the metabolism of bavachin. In addition, activity correlation analysis also supported the results above. Furthermore, the metabolism exhibited marked species differences, and rabbits were the appropriate model animals. Moreover, MRP4 was identified as the main contributor based on chemical inhibition and gene silencing approaches.

Conclusions
CYP1A1 and CYP2C9, UGT1A1, UGT1A7, UGT1A8 and UGT1A9, and MRP4 all played important roles in the metabolism and disposition of bavachin.
Markup Dispersion and Firm Entry: Evidence from Ethiopia*
Authors: Damoah Kaku Attah , Giovannetti Giorgia , Sanfilippo Marco 
Published: July 2020

AbstractThis paper examines whether and to what extent markups can influence structural transformation in a developing country by creating entry barriers. We exploit information from the Ethiopian annual census of manufacturing establishments to estimate markups and their dispersion at industry and woreda‐industry‐wide levels. We then analyse the relationship between markup dispersion and firm entry rates in local markets. Results show that higher markup dispersion significantly correlates with lower entry rates into a market, even in the presence of expected positive average markups. Specifically, an increase in dispersion from its median to the values at the 90th percentile of the distribution is related to a 4.2% point lower entry rate. This result is robust to different estimation methods as well as to different definitions of the key variables.
Experimental Investigation and Simulation of a Boeing 747 Auxiliary Power Unit
Authors: Skliros Christos , Ali Fakhre , Jennions Ian 
Published: July 2020

Abstract
Auxiliary power units (APUs) are a major driver of maintenance on civil aircraft. However, experimental data and performance simulations are rarely seen in public domain literature. While there is recourse to aircraft engine experience, this does not address the loading and the failure modes of an APU. This work aims to add to the literature, by experimentally investigating a Boeing 747 APU, collecting data under various power settings and ambient conditions, and using these data to calibrate a simple simulation model. This simulation model will subsequently be used to explore failure modes in the APU and hence what sensors may be needed for health monitoring purposes in future work. In this paper, a Boeing 747 APU rig development process and the testing strategy are presented. The rig is validated through a process that includes uncertainty analysis, repeatability tests, consistency tests, and comparison of the collected data with the calibrated simulation model. The results from the rig's validation indicate that the data collected from the APU is independent of its running time or the order of loading cycles imposed on it, i.e., the results are path independent. Changes in pneumatic and electrical power result in small changes in the rotational speed despite the fact that the rotational speed should remain constant. The rotational speed shows a slightly increasing trend when the extracted power rises, and this affects the APU thermodynamic characteristics. This work has resulted in a calibrated simulation model that will be further used in examining fault mode scenarios, as injecting these directly into the rig is seen as high risk.
Exergy and NOx Emission-Based Ecological Performance Analysis of the Scimitar Engine
Authors: Tanbay Tayfun , Durmayaz Ahmet 
Published: July 2020

Abstract
Scimitar engine is a hypersonic hybrid engine designed to propel the LAPCAT A2 aircraft. In this study, a novel exergy and NOx emission-based ecological performance analysis of the engine is performed. For this purpose, first, a component-based exergy analysis for the cruise phase of the Scimitar engine in air-turborocket mode is performed and the exergy destruction rates of engine components are determined at Mach 5 by the thermodynamic model developed. Then, a novel objective function, the coefficient of emission-based ecological performance (CEEP) is defined as “the propulsive power produced per unit environmentally harmful exhaust gas emission rate,” which can be utilized to assess the ecological impact of any jet engine. Finally, the impacts of cruise speed, altitude, and air and fuel mass flow rates on the exergetic and NOx emission-based ecological performance of the engine are investigated by the aid of the newly defined CEEP, together with the exergy efficiency and the coefficient of ecological performance. It is found that the combustion chamber is responsible for 57.36% of the overall exergy destruction rate of 123.80 MW at the cruise conditions, and CEEP relatively increases by 13.8% when the hydrogen fuel consumption rate is increased from 3.96 kg/s to 4.17 kg/s. Increasing the cruise speed from Ma = 4.88 to Ma = 5.2 and decreasing the altitude from 25 km to 23 km cause a relative degradation of 12.75% in CEEP.
Understanding key mechanisms of successfully leading integrated team-based services in health and social care: protocol for a realist synthesis
Authors: Harris Ruth , Fletcher Simon , Sims Sarah , Ross Fiona , Brearley Sally , Manthorpe Jill 
Published: July 2020

IntroductionAs systems of health and social care in England move towards more integrated and collaborative models, leaders will need different skills than their predecessors to enable system leadership, building partnerships and working across organisations and sectors. There is little understanding of what the mechanisms for effective leadership across integrated health and social care systems might be, the contexts that influence good leadership, or the nature of the resulting outcomes. This review aims to identify, refine and test programme theories of leadership of integrated team-based services in health and social care, exploring what works, for whom and in what circumstances.Methods and analysisThis study uses a realist synthesis approach, following RAMESES guidelines, supported by stakeholder consultation. Stage 1 will develop initial programme theories about leadership of integrated health and social care based on a review of the scientific and grey literature and a stakeholder consultation workshop. Stage 2 will involve focused searching of empirical literature, data extraction and synthesis to refine the initial programme theories and identify relationships between identified contexts, mechanisms and outcomes. A second stakeholder event will guide the focus of the review. Stage 3 will further refine and interrogate the theories testing them against substantive theory on leadership of complex systems and through the experiences and expertise of the stakeholder group.Ethics and disseminationOur study does not require ethics committee approval. This research will contribute to building an in-depth understanding of what aspects of leadership of integrated team-based services work, for whom and in what circumstances. It will identify the professional development needs of leaders and provide recommendations about optimal organisational and interorganisational structures and processes that support effective leadership in integrated health and social care systems. Findings will be disseminated through peer-reviewed journal publications, conference presentations and formal and informal reports.PROSPERO registration numberCRD42018119291
Whole exome sequencing analyses reveal gene–microbiota interactions in the context of IBD
Authors: Hu Shixian , Vich Vila Arnau , Gacesa Ranko , Collij Valerie , Stevens Christine , Fu Jack M , Wong Isaac , Talkowski Michael E , Rivas Manuel A , Imhann Floris , Bolte Laura , van Dullemen Hendrik , Dijkstra Gerard , Visschedijk Marijn C , Festen Eleonora A , Xavier Ramnik J , Fu Jingyuan , Daly Mark J , Wijmenga Cisca , Zhernakova Alexandra , Kurilshikov Alexander , Weersma Rinse K 
Published: July 2020

ObjectiveBoth the gut microbiome and host genetics are known to play significant roles in the pathogenesis of IBD. However, the interaction between these two factors and its implications in the aetiology of IBD remain underexplored. Here, we report on the influence of host genetics on the gut microbiome in IBD.DesignTo evaluate the impact of host genetics on the gut microbiota of patients with IBD, we combined whole exome sequencing of the host genome and whole genome shotgun sequencing of 1464 faecal samples from 525 patients with IBD and 939 population-based controls. We followed a four-step analysis: (1) exome-wide microbial quantitative trait loci (mbQTL) analyses, (2) a targeted approach focusing on IBD-associated genomic regions and protein truncating variants (PTVs, minor allele frequency (MAF) >5%), (3) gene-based burden tests on PTVs with MAF <5% and exome copy number variations (CNVs) with site frequency <1%, (4) joint analysis of both cohorts to identify the interactions between disease and host genetics.ResultsWe identified 12 mbQTLs, including variants in the IBD-associated genes IL17REL, MYRF, SEC16A and WDR78. For example, the decrease of the pathway acetyl-coenzyme A biosynthesis, which is involved in short chain fatty acids production, was associated with variants in the gene MYRF (false discovery rate <0.05). Changes in functional pathways involved in the metabolic potential were also observed in participants carrying rare PTVs or CNVs in CYP2D6, GPR151 and CD160 genes. These genes are known for their function in the immune system. Moreover, interaction analyses confirmed previously known IBD disease-specific mbQTLs in TNFSF15.ConclusionThis study highlights that both common and rare genetic variants affecting the immune system are key factors in shaping the gut microbiota in the context of IBD and pinpoints towards potential mechanisms for disease treatment.