bluuebunny/crossref_metadata_2025_split huggingface dataset:
A blood-based comprehensive and systems-level analysis of disease stages, immune regulation and symptoms in COVID-19 patients
Authors: Sadanandam Anguraj , Bopp Tobias , Dixit Santosh , Knapp David JHF , Emperumal Chitra Priya , Rajalingam Krishnaraj , Melcher Alan , Kannan Nagarajan 
Published: May 2020

Abstract
COVID-19 patients show significant clinical heterogeneity in presentation and outcomes that makes pandemic control and strategy difficult; optimising management requires a systems biology approach of understanding the disease. Here we sought to understand and infer complex system-wide changes in patients infected with coronaviruses (SARS-CoV and SARS-CoV-2; n=38 and 57 samples) at two different disease stages compared with healthy individuals (n=16) and patients with other infections (n=144). We applied inferential statistics/machine-learning approaches (the COVID-engine platform) to RNA profiles derived from peripheral blood mononuclear cells (PBMCs). Compared to healthy individuals, an integrated blood-based gene signatures distinguished acute-like (mimicking coronavirus-infected patients with prolonged hospitalisation) from recovering-like patients. These signatures also hierarchically represented systems-level parameters associated with PBMC including dysregulated cytokines, genes, pathways, networks of pathways/concepts, immune status, and cell types. Proof-of-principle confirmatory observations included PBMC-associated increases in ACE2, cytokine storm-associated IL6, enhanced innate immunity (macrophages and neutrophils), and lower adaptive T and B cell immunity in patients with acute-like disease compared to those with recovery-like disease. Patients in the recovery-like stage had significantly enhanced TNF, IFN-g, anti-viral, HLA-DQA1, and HLA-F gene expression and cytolytic activity, and reduced pro-viral gene expression compared to those in the acute-like stage in PBMC. Besides, PBMC-derived surrogate-based approach revealed overlapping genes associated with comorbidities (associated diabetes), and disease-like symptoms (associated with thromboembolism, pneumonia, lung disease and septicaemia). Overall, our study involving PBMC-based RNA profiling may further help understand complex and variable systems-wide responses displayed by coronavirus-infected patients.
Real-time audio and visual display of the Coronavirus genome
Authors: Temple Mark D. 
Published: May 2020

Abstract
Background:This paper describes a web based tool that uses a combination of sonification and an animated display to inquire into the SARS-CoV-2 genome. The audio data is generated in real time from a variety of RNA motifs that are known to be important in the function of RNA. Additionally metadata relating to RNA translation and transcription has been used to shape the auditory and visual displays. Together these tools provide a unique approach to further understand the metabolism of the viral RNA genome. This audio provides a further means to represent the function of the RNA in addition to traditional written and visual approaches.Results:Sonification of the SARS-CoV-2 genomic RNA sequence results in a complex auditory stream composed of up to 12 individual audio tracks. Each auditory motive is derived from the actual RNA sequence or from metadata. This approach has been used to represent transcription or translation of the viral RNA genome. The display highlights the real-time interaction of functional RNA elements. The sonification of codons derived from all three reading frames of the viral RNA sequence in combination with literature derived metadata provide the framework for this display. Functional RNA motifs such as transcription regulatory sequences and stem loop regions have also been sonified. Using the tool, audio can be generated in real-time from either genomic or sub-genomic representations of the RNA. Given the large size of the viral genome, a collection of interactive buttons have been provided to navigate to regions of interest, such as cleavage regions in the polyprotein, untranslated regions or each gene. These tools are available through an internet browser and the user can interact with the data display in real time. Conclusion:The auditory display in combination with real-time animation of the process of translation and transcription provide a unique insight into the large body of evidence describing the metabolism of the RNA genome. Furthermore the tool has been used as an algorithmic based audio generator. These audio tracks can be listened to by the general community without reference to the visual display to encourage further inquiry into the concept.
Dikkat Eksikliği Hiperaktivite Bozukluğu Olan Çocukların Anadolu-Sak Zekâ Ölçeği Profillerinin İncelenmesi
Authors: CIRIK Mevlüt , SAK Uğur , ÖPENGİN Ercan 
Published: May 2020

Dikkat eksikliği hiperaktivite bozukluğunun (DEHB) tanılanmasında zekâ ölçekleri birey hakkında ek bilgi elde etmek için zaman zaman kullanılmaktadır çünkü DEHB zekaya ilişkin bazı bilişsel süreçlere ket vurabilmekte veya bu süreçlerin etkin olarak yürütülmesini engelleyebilmektedir Bu nedenle DEHB tanısı olan çocuklar zeka ölçeklerinde farklılaşan profiller sergilemektedir. Bu da zeka ölçeklerinin DEHB tanısında tutarlı profiller ortaya koymasını engellemektedir. Zeka ölçeklerinin DEHB’nin tanılanmasında yordayıcılığının belirlenmesi için önceden tanı almış bireylerin zekâ ölçeklerinde ortaya koydukları bilişsel profiller incelenmektedir. Bu araştırmada DEHB tanısı almış çocukların Milli Eğitim Bakanlığı (MEB) bünyesinde yer alan Rehberlik ve Araştırma Merkezleri’nde (RAM) 2017 yılı itibariyle kullanılmaya başlanan Anadolu Sak Zeka Ölçeği’nde (ASİS) gösterdikleri bilişsel profillerin incelenmesi amaçlanmıştır. Araştırmada ilişkisel tarama modeli kullanılmıştır. Araştırma kapsamında önceden DEHB tanısı almış 102 çocuğa ASİS uygulanmıştır. Elde edilen bulguların ASİS norm puanları ile ayrıca grup içi karşılaştırması yapılmıştır. DEHB’li çocukların ASİS endeks ve alt testlerinin tamamında norm grubu ortalamasından anlamlı derecede düşük performans gösterdikleri ortaya çıkmıştır. Endeksler incelendiğinde grubun Bellek Kapasite Endeksi (BKE) ortalamasının, Sözel Potansiyel Endeksi (SPE) ve Görsel Potansiyel Endeksi (GPE) ortalamasından anlamlı derecede düşük olduğu görülmüştür. Alt testler incelendiğinde katılımcıların işleyen belleğinin bir bileşeni olan görsel ardıl işleyen bellek ve dil gelişiminin bir boyutu olan sözcükler anlamlar alt testinde diğer alt testlerden anlamlı derecede düşük performans gösterdikleri bulgusuna ulaşılmıştır. DEHB tanılı çocukların ASİS’te sergiledikleri profiller, dikkat eksikliği ve hiperaktivite bozukluğu olan bireylerde işleyen belleğin zayıf olduğunu, buna bağlı olarak öğrenmenin, özellikle dil ediniminin düşük düzeyde olabileceğini göstermektedir.
Spatio-temporal analysis of maximum drought severity using Copulas in Northern Algeria
Authors: Mellak Soumia , Souag-Gamane Doudja 
Published: May 2020

Abstract
Drought mitigation and prevention require a broader knowledge of the spatio-temporal characteristics and return periods of droughts over several years. In this research, drought characteristics (severity, duration, frequency and areal extent) have been analysed in northern Algeria by using the Standardized Precipitation Index to identify drought events from 194 precipitation stations. For frequency analysis, three Archimedean copula families were used to find a relationship between drought duration and severity. The severity–duration–frequency (SDF) and the severity–area–frequency (SAF) curves were obtained. The SDF and SAF curves are then used to build three-dimensional surfaces of drought severity, drought duration and cumulated percentage of the affected area (SDA) for each return period. It has been shown that the return periods of maximum drought events severity vary according to their durations. To address the issue of long-term droughts, a new classification of dry events based on drought severities is proposed. The obtained results show that the western part of Algeria is the most sensitive to severe/extreme droughts of short durations and high probabilities of exceedance. For long-term durations, the study area was sensitive to mild droughts with lower probabilities.
Analysis of minimal and maximal pressures, uncertainty and spectral density of fluctuating pressures beneath classical hydraulic jumps
Authors: Mousavi Seyed Nasrollah , Farsadizadeh Davood , Salmasi Farzin , Dalir Ali Hosseinzadeh , Bocchiola Daniele 
Published: May 2020

Abstract
Knowledge of extreme pressures and fluctuations within stilling basins is of the utmost importance, as they may cause potential severe damages. It is complicated to measure the fluctuating pressures of hydraulic jumps in real-scale structures. Therefore, little information is available about the pressure fluctuations in the literature. In this paper, minimal and maximal pressures were analyzed on the flat bed of a stilling basin downstream of an Ogee spillway. Attention has been focused on dimensionless pressures related to the low and high cumulative probabilities of occurrence (P*0.1% and P*99.9%), respectively. The results were presented based on the laboratory-scale experiments. These parameters for the relatively high Froude numbers have not been investigated. The total standard uncertainty for the dimensionless mean pressures (P*m) was obtained around 1.87%. Spectral density analysis showed that the dominant frequency in the classical hydraulic jumps was about 4 HZ. Low-frequency of pressure fluctuations indicated the existence of large-scale vortices. In the zone near the spillway toe, P*0.1% reached negative values of around −0.3. The maximum values of pressure coefficients, namely |CP0.1%|max and CP99.9%max, were achieved around 0.19 and 0.24, respectively. New original expressions were proposed for P*0.1% and P*99.9%, which are useful for estimating extreme pressures.
Improved Outcomes after Reperfusion Therapies for Ischemic Stroke: A “Real-world” Study in a Developing Country
Authors: Schulz Victor C. , de Magalhaes Pedro S.C. , Carneiro Camila C. , da Silva Julia I.T. , Silva Vivian N. , Guesser Vanessa V. , Safanelli Juliana , Diegoli Henrique , Liberato Rafaela B. , Lopes Cristiane C.C. , de Souza Aline , de França Paulo H.C. , Conforto Adriana B. , Cabral Norberto L. 
Published: May 2020

Background:
It is unknown if improvements in ischemic stroke (IS) outcomes reported
after cerebral reperfusion therapies (CRT) in developed countries are also applicable to the “real
world” scenario of low and middle-income countries. We aimed to measure the long-term outcomes
of severe IS treated or not with CRT in Brazil.

Methods:
Patients from a stroke center of a state-run hospital were included. We compared the
survival probability and functional status at 3 and 12 months in patients with severe IS treated or
not with CRT. From 2010 to 2011, we performed intravenous reperfusion when patients arrived
within 4.5 h time-window (IVT group) and after 2011, mechanical thrombectomy (MT) combined
or not with intravenous alteplase (IAT group). Those who arrived >4.5 h in 2010-2011 and >6 h in
2012-2017 did not undergo CRT (NCRT group).

Results:
From 2010 to 2017, we registered 917 patients: 74% (677/917) in the NCRT group, 19%
(178/917) in the IVT group and 7% (62/917) in the IAT group. Compared to the NCRT group,
IVT patients had a 28% higher (HR: 0.72; 95% CI 0.53-0.96) 3-month adjusted probability of survival
and risk of functional dependence was 19% lower (adjusted RR: 0.81; 95% CI 0.73-0.91).
For those who underwent MT, the adjusted probability of survival was 59 % higher (HR: 0.41;
95% CI 0.21-0.77) and the risk of functional dependence was 21% lower (adjusted RR: 0.79; 95%
CI 0.66-094). These outcomes remained significantly better throughout the first year.

Conclusion:
CRT led to better outcomes in patients with severe IS in Brazil.
Diverse Routes for the Synthesis of Indole-Fused Complex Architecture from Simple Molecules
Authors: Singh Shivendra , Chauhan Suresh Singh , Sharma Neeraj Kumar , Dutt Sunil , Ameta Keshav Lalit 
Published: May 2020

:
Several easy, efficient and convenient procedures to access indoles fused heterocyclic systems
are described in this review. These heterocyclic systems were synthesized from several cyclic or
acyclic molecules via a variety of reactions such as Diels-Alder reaction, Michael addition, Morita-
Baylis-Hillmann reaction and many other domino/Cascade approaches with high selectivity. Most of
the given protocols in this review proceed through organocatalytic pathways; however, some underwent
different catalytic and non-catalytic reactions.
The Effect of Cognitive Group Counseling on Women’s Motivation for Childbearing-an Interventional Study
Authors: Sheikhganbar Narges , Vakilian Katayon , Abbasi Zohreh , Ranjbaran Mehdi , Amoozegar Hoora 
Published: May 2020

Background:
Postponing parenthood is associated with decreased number of offspring
and increased pregnancy risks.

Objectives:
The present study aimed to investigate the effect of cognitive group counseling on
childless couples' decision motivation for childbearing and preconception checkup.

Methods:
This experimental study was performed on 62 fertile women referred to health care centers
in Qom. Signing the written consent form, the participants who were selected by the convenience
sampling method entered the study. Childbearing Questionnaire (CBQ) was used to collect
data. 6 cognitive group counseling sessions were conducted for the intervention group while the
control group did not receive any training except one session on the disadvantages of postponed
childbearing by the midwife under the supervision of the researcher. After the intervention, childbearing
motivation was evaluated in both groups. The samples were also evaluated in one and two
months after the intervention to see whether they have referred for pre-pregnancy checkups. The
data were analyzed by SPSS20 using chi-square, and independent t-test. P-value was considered to
be less than 0.05.

Results:
The results showed that after the intervention, the mean of Positive Childbearing Motivation
(PCM) in the intervention group was significantly higher than that of the control group and the
mean of Negative Childbearing Motivation (NCM) was significantly lower than that of the control
group (p <0.001). The frequency of booking pre-pregnancy checkups two months after intervention
was 69.57% and 10% in the intervention and control groups, respectively.

Conclusion:
Counseling could be more effective to motivate women to start booking for prepregnancy
checkups.
Green Synthesis of Silver, Copper and Gold Nanoparticles Using Terminalia arjuna Bark and their Effect on Seed Germination
Authors: Sharma Rama , Gupta Hariom 
Published: May 2020

Background:
Terminalia arjuna has many biological applications including synthesis
of metal nanoparticles, which have no hazardous effect on the environment. We have demonstrated
that metal nanoparticles synthesized using Terminalia arjuna bark can be used to enhance the
germination of seeds.

Methods:
To evaluate the effect on germination, we treated Vigna unguiculata (black-eyed peas)
seeds with copper, silver and gold nanoparticles synthesized by Terminalia arjuna bark. The synthesized
metal nanoparticles were characterized by UV-spectroscopy and their size was confirmed
by diffraction light scattering technique.

Results:
After incubation of 48 hours, the effects were observed. It was observed that Vigna
unguiculata (black-eyed peas) seed showed 30% germination in silver nanoparticles solution and
70% in copper nanoparticles, whereas 0% germination was observed in gold nanoparticles.

Conclusions:
The results obtained in the study show that nanobiotechnology can be applied in
agriculture to boost the production of crops.
Do Talent Management Practices Affect Organizational Culture?
Authors: Lutfi Al-Dalahmeh Maha , Dajnoki Krisztina 
Published: May 2020

The purpose of this paper is to enhance the readers' understanding of the domain of talent management and organisational culture and how talent management becomes one of the important strategic tools to improve the work environment, specifically as a tool for enhancing the organizational culture. The paper also attempts to probe and aid readers in understanding to what extent talent management affects the organizational culture. This paper is based on secondary research and articles in the areas of talent management, organizational culture and the relationship between them. The author has reviewed the existing body of work on these topics to arrive at the analysis of the relationship between talent management and organizational culture. As well as measuring its impact on the whole organization by reviewing the existing literature.
Digital Media as a Proponent for Healthy Aging in the Older Chinese American Population: Longitudinal Analysis
Authors: Shu Sara , Woo Benjamin K P 
Published: May 2020

Background
Ensuring health literacy among underserved populations is essential amid an aging population. Accessible and appropriate (both culturally and linguistically) information is important when considering digital media education for older Chinese Americans.

Objective
This study aims to investigate how social media fare over time in disseminating health information and how we may most effectively educate this population.

Methods
For this study, 5 geriatric-themed educational videos about Parkinson disease, fall prevention, gastrointestinal health, oral health, and pulmonary disease were uploaded to YouTube. Data were collected over a 40-month period. Descriptive statistics and chi-square analysis were used to compare results from the first and second 20-month periods.

Results
In 40 months, the 5 videos in aggregate accrued 1171.1 hours of watch time, 7299 views, and an average view duration of 9.6 minutes. Comparing the first and second 20-month periods, there was a significant increase in mobile device usage, from 79.4% (3541/4458) to 83.3% (2367/2841). There was no significant difference in the usage of various external traffic sources and methods of sharing, with WhatsApp accounting for the majority of sharing in both 20-month periods.

Conclusions
Our study provides insight into where to focus future strategies to optimize digital media content, and how to best recruit, direct, and disseminate health education to an older adult Chinese American population. Combining the success of YouTube, social media, and messaging platforms such as WhatsApp can help to transcend cultural and linguistic barriers to promote healthy aging.
DRUG UTILIZATION STUDY ON ORAL HYPOGLYCEMIC AGENTS IN TYPE 2 DIABETIC PATIENTS OF TERTIARY CARE HOSPITAL
Authors: BHUVANESWARI SARAGADAM 
Published: May 2020

Objective: The main objective of the study is to determine the patient demographic characteristics, inspect prescription patterns of oral hypoglycemic agents, distribution of comorbid conditions in the outpatient department (OPD) of Visakha Institute of Medical Sciences (VIMS), Visakhapatnam.
Method: A prospective observational study was conducted in patients with established type 2 diabetes mellitus (n=185) visiting OPD which were interviewed using a structured questionnaire during the period September– December 2019.
Results: Majority of the type 2 diabetic patients in VIMS were treated with double drug therapy. The most commonly prescribed class of oral hypoglycemic agents were biguanides (metformin) followed by sulfonylureas (glimepiride), thiazolidinediones (pioglitazone), alpha-glucosidase inhibitor (voglibose), and dipeptidyl peptidase-4 inhibitor (vildagliptin).
PRESCRIBING TREND AMONG HOSPITALIZED PEDIATRIC PATIENTS IN PRIVATE SECTOR HOSPITAL: A PROSPECTIVE OBSERVATIONAL STUDY IN NADIAD, INDIA
Authors: B PATEL SANDIP , P PATEL YASH , B SHAH SHISHAV 
Published: May 2020

Objectives: Purpose of this study was to analyze the prescription pattern among the hospitalized pediatric patients in private sector hospital.
Methods: The study was conducted from January 2018 to April, 2018 at Shaishav Hospital, Nadiad, Gujarat, India, and 178 patients were included into the study. Results were obtained by applying the World Health Organization (WHO) prescribing indicators as well as Indian Academy of Pediatrics List of Essential Medicines (IAP-LEM).
Results: During the study period, infectious disease such as pneumonitis, bronchitis, enteric fever, gastroenteritis, and dehydration were the dominant disease among the patients. Average number of drugs per prescription was four but in many of prescription, poly-pharmacy has shown. Antibiotic agents were the most prescribed drug (38.6%) among different classes of drugs. Use of the parenteral route of drug administration was used beyond the range stated by the WHO (59% prescriptions vs. 13–24% WHO range). We found that doctor followed IAP-LEM (in 99.78% cases) for prescribing as well as for dosing also, which was very impressive.
Conclusions: As this study indicates, there is a need of development of evidence-based treatment protocols for common disease condition for the rational use of medication, especially for an antibiotic medication.
DESIGN SYNTHESIS OF NOVEL ACRIDINE TAGGED PYRAZOLE DERIVATIVES AS AURORA KINASE INHIBITORS
Authors: PERKA HARATHI , D SATYAVATI , REDDY GADE DEEPAK , BOYA VIVEKANANDA , PRASAD VVS RAJENDRA 
Published: May 2020

Objective: A series of novel synthesis of 5-Substituted-3-phenyl-4,5-dihydro-pyrazole-1-carbothioic acid [4-(9, 10-dihydro-acridin-9-yl)-phenyl]- amide (IV) were synthesized using standard procedures and evaluated for cytotoxic studies.
Methods: 9-(4-Chloro-phenyl)-9 and 10-dihydro-acridine (I) were formed by cyclization of diphenylamine with substituted acids in the prescience of zinc chloride and synthesis of 5-substituted-3-phenyl-4, 5-dihydro-pyrazole-1-carbothioic acid amide (3) by the cyclization of different chalcones (II) and final compounds were synthesized by fusion of 5-substituted-3-phenyl-4, 5-dihydro-pyrazole-1-carbothioic acid amide (III) with 9-(4-Chloro-phenyl)-9, 10-dihydro-acridine (I) by microwave irradiation method. Characterization of synthesized compounds by infrared, 1H nuclear magnetic resonance (NMR), 13C NMR, and mass spectroscopic methods. Obtained compounds were evaluated for their cytotoxicity against human breast cancer cell lines (MCF/wt) by sulforhodamine-B assay. Docking studies with Aurora kinase protein were performed to elucidate the possible mechanistic insights of these novel acridine tagged pyrazole derivatives.
Results: Moderate to good in vitro cytotoxic potentials of the newly synthesized molecules was reported against selected human breast cancer cell lines. Among the tested molecules, compound C6 showed good cytotoxic activity against MCF/wt (08.2±0.4 μM). The dock scores of the tested compounds were ranged between −8.926 and −5.139. Compound C6 which has been reported as the most effective cytotoxic agent among the series also reported the highest dock score of -8.926 and showed hydrogen bond interaction with GLU-211, LYS-162, and LYS-143. Ligand binding energy with protein suggested compound C6 has shown the highest binding energy of −86.32133 kcal/mol.
Conclusion: The in vitro studies of the newly synthesized acridine tagged pyrazole derivatives reported considerable cytotoxic potentials against human breast cancer cell lines and structure-activity relationship studies to suggest that acridine tagged pyrazole derivatives with hydroxy group present on phenyl ring at fifth position of pyrazole ring could probably increase the cytotoxic potentials. With the reported bioactivities of these derivatives, further studies on the derivatization could elucidate the broader cytotoxic potentials.