bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune profile and immunosurveillance in treatment-naive and neoadjuvantly treated esophageal adenocarcinoma
Authors: Wagener-Ryczek Svenja , Schoemmel Max , Kraemer Max , Bruns Christiane , Schroeder Wolfgang , Zander Thomas , Gebauer Florian , Alakus Hakan , Merkelbach-Bruse Sabine , Buettner Reinhard , Loeser Heike , Thelen Martin , Schlößer Hans A. , Quaas Alexander 
Published: January 2020

AbstractThe outcome in esophageal adenocarcinoma (EAC) is still poor with only 20% of patients in Western populations surviving for more than 5 years. Almost nothing is known about the precise composition of immune cells and their gene expression profiles in primary resected EACs and also nothing compared to neoadjuvant treated EACs. This study analyzes and compares immune profiles of primary resected and neoadjuvant treated esophageal adenocarcinoma and unravels possible targets for immunotherapy. We analyzed 47 EAC in total considering a set of 30 primary treatment-naive EACs and 17 neoadjuvant pretreated (12 × CROSS, 5 × FLOT) using the Nanostring's panel-based gene expression platform including 770 genes being important in malignant tumors and their immune micromileu. Most of the significantly altered genes are involved in the regulation of immune responses, T-and B cell functions as well as antigen processing. Chemokine-receptor axes like the CXCL9, -10,-11/CXCR3- are prominent in esophageal adenocarcinoma with a fold change of up to 9.5 promoting cancer cell proliferation and metastasis. ARG1, as a regulator of T-cell fate is sixfold down-regulated in untreated primary esophageal tumors. The influence of the currently used neoadjuvant treatment revealed a down-regulation of nearly all important checkpoint markers and inflammatory related genes in the local microenvironment. We found a higher expression of checkpoint markers like LAG3, TIM3, CTLA4 and CD276 in comparison to PD-L1/PD-1 supporting clinical trials analyzing the efficacy of a combination of different checkpoint inhibitors in EACs. We found an up-regulation of CD38 or LILRB1 as examples of additional immune escape mechanism.
Elevated plasma tyrosine kinases VEGF-D and HER4 in heart failure patients decrease after heart transplantation in association with improved haemodynamics
Authors: Ahmed Salaheldin , Ahmed Abdulla , Säleby Joanna , Bouzina Habib , Lundgren Jakob , Rådegran Göran 
Published: January 2020

AbstractReceptor tyrosine kinases (RTKs) are implicated in cardiovascular growth and remodelling. We aimed to identify the plasma levels of RTKs and related proteins and their association with haemodynamic alterations in heart failure (HF) and related pulmonary hypertension (PH) following heart transplantation (HT). Using proximity extension assay, 28 RTKs and related proteins were analysed in plasma from 20 healthy controls and 26 HF patients before and 1-year after HT. In end-stage HF, out of 28 RTKs, plasma vascular endothelial growth factor-D (VEGF-D) and human epidermal growth factor-4 (HER4) were elevated compared to controls (p < 0.001), but decreased (p < 0.0001) and normalised after HT. Following HT, plasma changes (Δ) of VEGF-D correlated with Δmean pulmonary artery pressure (rs = 0.65, p = 0.00049), Δpulmonary artery wedge pressure (rs = 0.72, p < 0.0001), Δpulmonary arterial compliance (PAC) (rs = − 0.52, p = 0.0083) and Δpulmonary vascular resistance (PVR) (rs = 0.58, p = 0.0032). ΔHER4 correlated with Δmean right atrial pressure (rs = 0.51, p = 0.012), ΔNT-proBNP (rs = 0.48, p = 0.016) and Δcardiac index (rs = − 0.56, p = 0.0044). In HF patients following HT, normalisation of VEGF-D reflected reversal of passive pulmonary congestion and restored PAC and PVR; whereas the normalisation of HER4 reflected decreased volume overload and improved cardiac function. The precise function of these proteins, their potential clinical use and pathophysiological relation in HF and related PH remain to be elucidated.
Ranking Self-reported Gastrointestinal Side Effects of Pharmacotherapy in Sarcoidosis
Authors: Drent M. , Proesmans V. L. J. , Elfferich M. D. P. , Jessurun N. T. , de Jong S. M. G. , Ebner N. M. , Lewis E. D. O. , Bast A. 
Published: January 2020

AbstractBackgroundClinical manifestations of sarcoidosis vary widely, depending on the intensity of the inflammation and the organ systems affected. So far, no curative treatment exists; the disease can only be suppressed. All treatment options cause side effects affecting quality of life. The aim of this study was to establish and rank the prevalence of self-reported gastrointestinal side effects of drugs used in the treatment of sarcoidosis.MethodsA cross-sectional web-based anonymous survey about complaints and side effects was conducted among sarcoidosis patients in the Netherlands, United Kingdom, and United States of America.ResultsOf the participants, 70% were being treated with one or more drugs. The most important reported side effect was weight gain, associated with increased appetite among prednisone users (as monotherapy as well as in combination with other drugs). Methotrexate (MTX) users especially experienced nausea, with monotherapy as well as combination therapy. Vomiting and weight loss were most prominent among azathioprine and mycophenolate mofetil (MMF) users, whereas diarrhoea was frequently mentioned by MMF and MTX users. The reported side effects of hydroxychloroquine were generally rather mild.ConclusionThe current study ranked the gastrointestinal side effects associated with pharmacotherapy in sarcoidosis patients. Pharmacotherapy does have multiple gastrointestinal side effects. The strongest association between a reported side effect and drug use was that of weight gain associated with increased appetite among prednisone users. It would therefore be useful for future research to look further into dietary interventions to counter these side effects and reduce their burden.
Measuring the accuracy of software vulnerability assessments: experiments with students and professionals
Authors: Allodi Luca , Cremonini Marco , Massacci Fabio , Shim Woohyun 
Published: January 2020

AbstractAssessing the risks of software vulnerabilities is a key process of software development and security management. This assessment requires to consider multiple factors (technical features, operational environment, involved assets, status of the vulnerability lifecycle, etc.) and may depend from the assessor’s knowledge and skills. In this work, we tackle with an important part of this problem by measuring the accuracy oftechnicalvulnerability assessments by assessors with different level and type of knowledge. We report an experiment to compare how accurately students with different technical education and security professionals are able to assess the severity of software vulnerabilities with the Common Vulnerability Scoring System (v3) industry methodology. Our results could be useful for increasing awareness about the intrinsic subtleties of vulnerability risk assessment and possibly better compliance with regulations. With respect to academic education, professional training and human resources selections our work suggests that measuring the effects of knowledge and expertise on the accuracy of software security assessments is feasible albeit not easy.
Perceptions and Experiences of Health and Social Care Utilisation of the UK-Nepali Population
Authors: Simkhada Bibha , Sah Rajeeb Kumar , Mercel-Sanca Alan , van Teijlingen Edwin , Bhurtyal Yagya Murti , Regmi Pramod 
Published: January 2020

AbstractWith the growing UK Nepali community, understanding their health and social care
needs is an essential to reduce health and social care inequalities. However, very little
is known about the health, wellbeing and utilisation of health and social care services
among the Nepali population in the UK. Therefore, this study set out to identify health
and social care needs of Nepali community. The mixed-methods study was conducted with the Nepali population living in London. It
consists of a semi-structured survey (N = 345); three focus group discussions and three
key informant interviews. The mean age of the participants was 40.6 (± 17.6). About 28% of our sample reported
having chronic health problems. About 60% currently consume alcohol and 21% were
smokers. Male participants (35%) more likely to be physically active than females
(21%). Registration with a family doctor/general practitioner (GP) was high (96%).
However, uptake of disease screening was very low (28%). In the preceding year, 17%
had experienced poor mental or emotional health. The findings also suggest language is a key barrier to utilise health and social care
among UK Nepali. We suggest removing the language barrier is essential step to improve access to
available health and social care services. A culturally sensitive educational initiative
creating awareness about the structure of UK health and social care services is
required to offer to this community.
Game On—Complier Average Causal Effect Estimation Reveals Sleeper Effects on Academic Attainment in a Randomized Trial of the Good Behavior Game
Authors: Ashworth Emma , Panayiotou Margarita , Humphrey Neil , Hennessey Alexandra 
Published: January 2020

AbstractTo examine the efficacy of the Good Behavior Game (GBG) in improving children’s reading attainment, and the extent to which this varies as a function of cumulative intervention intensity (dosage) and timing of outcome measurement. A 2-year cluster-randomized controlled trial was conducted. Seventy-seven primary schools from three regions in England were randomly assigned to intervention and control groups. Children (N = 3084) aged 67 at baseline were the target cohort. The GBG is an interdependent group-contingency behavior management strategy used by teachers in elementary schools. Reading attainment was assessed via national teacher assessment scores at baseline, and the Hodder Group Reading Test at post-test and 1-year post-intervention follow-up. Dosage was assessed using a bespoke online GBG scoreboard system. Multi-level intent-to-treat (ITT) and complier average causal effect (CACE) estimation were utilized. At post-test, no effects of the GBG on children’s reading attainment were found in either the ITT or CACE models. At 1-year follow-up, results remained null in the ITT model, but a significant intervention effect was found among moderate compliers (Δ = 0.10) in the CACE model. The GBG can produce measurable improvements in children’s academic attainment, but these effects may take time to become apparent and are contingent upon implementation dosage falling within an optimal range. The project was supported by funding from the Education Endowment Foundation and the National Institute for Health Research. ISRCTN: 64152096.
Quality of life following road traffic injury: the impact of age and gender
Authors: Rissanen R. , Ifver J. , Hasselberg M. , Berg H.-Y. 
Published: January 2020

Abstract
Purpose
The impact of road traffic crashes on health is well developed, in terms of deaths and direct consequences, but it is less so in terms of long-term life consequences. Few studies have compared the general impact on Health Related Quality of Life (HRQoL) following road traffic injury (RTI) by using a variety of different injured body parts and severity levels of the injury and compared them with a sample of non-injured referent individuals. Consequently, the aim of the current study is to assess how injury severity is associated with HRQoL, and if it differs between men, women, over age and injured body parts.

Methods
This cross-sectional study identified people with a RTI in the Swedish Traffic Accident Data Acquisition System (STRADA). A frequency matched reference group was also included. Data include both register data and self-reported HRQoL data.

Results
A total of 1788 out of 4761 persons with an RTI (37.6%) and 2186 out of 4761 reference persons (45.9%) returned the questionnaire, giving a total response rate of 41.9% (n = 3974). The findings show different patterns of HRQoL loss, depending on sex, age, injured body part, and levels of injury severity.

Conclusion
The results show that even relatively minor road traffic injuries can lead to a significantly lower of HRQoL, especially for women, compared to the non-injured reference group. Moreover, when the inherent reduction of HRQoL over age was considered, the results indicated that younger individuals have a larger difference from the reference group in HRQoL, independent of the injury severity, compared to the older individuals; hence, an improved understanding of age and gender differences in HRQoL following an RTI is needed to better understand the long-term consequences of injuries from a public health perspective.
Experimental and Simulation Efforts in the Astrobiological Exploration of Exooceans
Authors: Taubner Ruth-Sophie , Olsson-Francis Karen , Vance Steven D. , Ramkissoon Nisha K. , Postberg Frank , de Vera Jean-Pierre , Antunes André , Camprubi Casas Eloi , Sekine Yasuhito , Noack Lena , Barge Laura , Goodman Jason , Jebbar Mohamed , Journaux Baptiste , Karatekin Özgür , Klenner Fabian , Rabbow Elke , Rettberg Petra , Rückriemen-Bez Tina , Saur Joachim , Shibuya Takazo , Soderlund Krista M. 
Published: January 2020

AbstractThe icy satellites of Jupiter and Saturn are perhaps the most promising places in the Solar System regarding habitability. However, the potential habitable environments are hidden underneath km-thick ice shells. The discovery of Enceladus’ plume by the Cassini mission has provided vital clues in our understanding of the processes occurring within the interior of exooceans. To interpret these data and to help configure instruments for future missions, controlled laboratory experiments and simulations are needed. This review aims to bring together studies and experimental designs from various scientific fields currently investigating the icy moons, including planetary sciences, chemistry, (micro-)biology, geology, glaciology, etc. This chapter provides an overview of successfulin situ,in silico, andin vitroexperiments, which explore different regions of interest on icy moons, i.e. a potential plume, surface, icy shell, water and brines, hydrothermal vents, and the rocky core.
A 3D Unstructured Mesh FDTD Scheme for EM Modelling
Authors: Gansen A. , El Hachemi M. , Belouettar S. , Hassan O. , Morgan K. 
Published: January 2020

AbstractThe Yee finite difference time domain (FDTD) algorithm is widely used in computational electromagnetics because of its simplicity, low computational costs and divergence free nature. The standard method uses a pair of staggered orthogonal cartesian meshes. However, accuracy losses result when it is used for modelling electromagnetic interactions with objects of arbitrary shape, because of the staircased representation of curved interfaces. For the solution of such problems, we generalise the approach and adopt an unstructured mesh FDTD method. This co-volume method is based upon the use of a Delaunay primal mesh and its high quality Voronoi dual. Computational efficiency is improved by employing a hybrid primal mesh, consisting of tetrahedral elements in the vicinity of curved interfaces and hexahedral elements elsewhere. Difficulties associated with ensuring the necessary quality of the generated meshes will be discussed. The power of the proposed solution approach is demonstrated by considering a range of scattering and/or transmission problems involving perfect electric conductors and isotropic lossy, anisotropic lossy and isotropic frequency dependent chiral materials.
Psychopathy and procrastination: Triarchic conceptualization of psychopathy and its relations to active and passive procrastination
Authors: Sanecka Elżbieta 
Published: January 2020

AbstractThe present study examined the relationships between potentially adaptive and maladaptive aspects of psychopathy distinguished within the triarchic model (i.e., boldness, meanness and disinhibition) and two types of procrastination, reflecting its functional and dysfunctional aspects (i.e., active procrastination and passive procrastination). Additionally, the potential mediating mechanisms underlying these associations were investigated. The results revealed that the three components of the triarchic model of psychopathy were related to different forms of procrastination in distinct ways. In particular, active procrastination displayed a positive link to boldness and meanness, whereas passive procrastination was found to be positively related to disinhibition and negatively to boldness. Furthermore, two parallel multiple mediation analyses demonstrated the mediating effects of individual difference variables (i.e., impulsiveness, negative affectivity, general self-efficacy) on these relationships. As hypothesized, impulsiveness and negative affectivity partially mediated the association between disinhibition and passive procrastination, while self-efficacy partially mediated the relationship between boldness and active procrastination. The paper concentrated on the theoretical implications of these findings for understanding how different psychopathy-related traits are related to different aspects of procrastination.
Efficacy of metabolites of a Streptomyces strain (AS1) to control growth and mycotoxin production by Penicillium verrucosum, Fusarium verticillioides and Aspergillus fumigatus in culture
Authors: Danial A. Mohd , Medina A. , Sulyok M. , Magan N. 
Published: January 2020

AbstractThe objectives of this study were to determine the efficacy of metabolites of a Streptomyces strain AS1 on (a) spore germination, (b) mycelial growth, (c) control of mycotoxins produced by Penicillium verrucosum (ochratoxin A, OTA), Fusarium verticillioides (fumonisins, FUMs) and Aspergillus fumigatus (gliotoxin) and (d) identify the predominant metabolites involved in control. Initial screening showed that the Streptomyces AS1 strain was able to inhibit the mycelial growth of the three species at a distance, due to the release of secondary metabolites. A macroscopic screening system showed that the overall Index of Dominance against all three toxigenic fungi was inhibition at a distance. Subsequent studies showed that the metabolite mixture from the Streptomyces AS1 strain was very effective at inhibiting conidial germination of P. verrucosum, but less so against conidia of A. fumigatus and F. verticillioides. The efficacy was confirmed in studies on a conducive semi-solid YES medium in BioScreen C assays. Using the BioScreen C and the criteria of Time to Detection (TTD) at an OD = 0.1 showed good efficacy against P. verrucosum when treated with the Streptomyces AS1 extract at 0.95 and 0.99 water activity (aw) when compared to the other two species tested, indicating good efficacy. The effective dose for 50% control of growth (ED50) at 0.95 and 0.99 aw were approx. 0.005 ng/ml and 0.15 μg/ml, respectively, with the minimum inhibitory concentration (MIC) at both aw levels requiring > 40 μg/ml. In addition, OTA production was completely inhibited by 2.5 μg/ml AS1 extract at both aw levels in the in vitro assays. Ten metabolites were identified with four of these being predominant in concentrations > 2 μg/g dry weight biomass. These were identified as valinomycin, cyclo(L-Pro-L-Tyr), cyclo(L-Pro-L-Val) and brevianamide F.
In vitro multi-enzymatic cascades using recombinant lysates of E. coli: an emerging biocatalysis platform
Authors: Alissandratos Apostolos 
Published: January 2020

AbstractIn recent years, cell-free extracts (or lysates) have (re-)emerged as a third route to the traditional options of isolated or whole-cell biocatalysts. Advances in molecular biology and genetic engineering enable facile production of recombinant cell-free extracts, where endogenous enzymes are enriched with heterologous activities. These inexpensive preparations may be used to catalyse multistep enzymatic reactions without the constraints of cell toxicity and the cell membrane or the cost and complexity associated with production of isolated biocatalysts. Herein, we present an overview of the key advancements in cell-free synthetic biology that have led to the emergence of cell-free extracts as a promising biocatalysis platform.
Patterns of Denitrification and Methanogenesis Rates from Vernal Pools in a Temperate Forest Driven by Seasonal, Microbial Functional Gene Abundances, and Soil Chemistry
Authors: Ayayee Paul A. , Taura Joseph , Roberto Alescia A. , Blackwood Christopher B. , Leff Laura G. 
Published: January 2020

AbstractDue to their relatively small sizes, temperate forest vernal pools are less studied than other wetlands, despite being potential biogeochemical hotspots in landscapes. We investigated spatial and temporal factors driving N2O and CH4 emission rates from vernal pools in a temperate forest. We determined higher N2O (3.66 ± 0.53 × 10−6, μg N2O/m2/h) and CH4 (2.10 ± 0.7 × 10−3, μg N2O/m2/h) rates in spring relative to fall (~50% and 77% lower for N2O and CH4 rates, respectively) and winter (~70% and 94% lower for N2O and CH4 rates, respectively). Soil organic matter, nitrate content and bacterial 16S rDNA, nirS, and norB gene abundances emerged as significant drivers of N2O rates, whereas, soil pH, organic matter content and mcrA abundance were significant drivers of CH4 rates. Denitrification gene abundances were negatively correlated with N2O rates, whereas mcrA abundance correlated positively with CH4 rates. Results suggest that CH4 rates may be directly coupled to methanogen abundance, whereas N2O rates may be directly impacted by a variety of abiotic variables and indirectly coupled to the abundance of potential denitrifier assemblages. Overall, additional studies examining these dynamics over extended periods are needed to provide more insights into their control.
Wire-Shaped 3D-Hybrid Supercapacitors as Substitutes for Batteries
Authors: Kang Kyeong-Nam , Ramadoss Ananthakumar , Min Jin-Wook , Yoon Jong-Chul , Lee Deokjung , Kang Seok Ju , Jang Ji-Hyun 
Published: January 2020

Abstract
We report a wire-shaped three-dimensional (3D)-hybrid supercapacitor with high volumetric capacitance and high energy density due to an interconnected 3D-configuration of the electrode allowing for large number of electrochemical active sites, easy access of electrolyte ions, and facile charge transport for flexible wearable applications. The interconnected and compact electrode delivers a high volumetric capacitance (gravimetric capacitance) of 73 F cm−3 (2446 F g−1), excellent rate capability, and cycle stability. The 3D-nickel cobalt-layered double hydroxide onto 3D-nickel wire (NiCo LDH/3D-Ni)//the 3D-manganese oxide onto 3D-nickel wire (Mn3O4/3D-Ni) hybrid supercapacitor exhibits energy density of 153.3 Wh kg−1 and power density of 8810 W kg−1. The red light-emitting diode powered by the as-prepared hybrid supercapacitor can operate for 80 min after being charged for tens of seconds and exhibit excellent electrochemical stability under various deformation conditions. The results verify that such wire-shaped 3D-hybrid supercapacitors are promising alternatives for batteries with long charge–discharge times, for smart wearable and implantable devices.