bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pioneering the future: incorporating lifestyle medicine tools in osteopathic medical education
Authors: Bansal Shipra , Shubrook Jay H. 
Published: February 2025

Abstract
The role of lifestyle has taken a renewed importance in disease prevention and chronic disease management. Osteopathic medicine has long focused on comprehensive, holistic care for our patients, and the tenets support the role of lifestyle medicine (LM) in osteopathic clinical care. In this commentary, the authors make the argument for incorporating LM more formally into the clinical curriculum at colleges of osteopathic medicine and will draw parallels with these two programs.
Assessing the efficacy of a hybrid closed loop system in a racial-ethnic minority cohort of children and adolescents with type 1 diabetes
Authors: Granados Andrea , Orrego Castellanos Juliana , Martinez Sanchez Andrea , Giraldo Maria Jose , Carrillo-Iregui Adriana 
Published: February 2025

Abstract

Objectives
Despite improved outcomes in the use of a hybrid closed loop system (HCLS), significant disparities in the application of this technology exist among youth with type 1 diabetes (T1DM). The study aimed to evaluate the impact of a tubeless HCLS on glycemic outcomes in a pediatric racial-ethnic minority population.

Methods
A retrospective, single-center study included youth with T1D initiating HCLS Omnipod 5. Outcomes included HbA1c, continuous glucose monitor variables, BMI Z score, and episodes of diabetic ketoacidosis (DKA). Outcomes were compared from baseline, 3 and 6 months of Omnipod 5 start.

Results
The study included 174 participants, aged between 2 and 22 years, with a mean age of 7.9 ± 3.7 years. Hispanics constituted 87.3 % (152) of the cohort, with 53 % males and 47 % females. Insurance coverage was 56.9 % public, 42.5 % private, and 0.5 % uninsured. Baseline HbA1c level was 8.0 % ± 1.7, 7.3 % ± 1.1 at 3 months and 7.3 % ± 1.1 at 6 months (p<0.001). Glucose time in range (TIR) was 54.5 % at baseline to 61.9 % at 3 months, and 60.5 % at 6 months (p<0.001). Notably, there were no changes in BMI z-scores or DKA episodes following the initiation of the HCLS Omnipod 5.

Conclusions
The study showed that a tubeless HCLS significantly improved glycemic control in a pediatric minority cohort with T1DM, without affecting BMI Z-scores or increasing DKA episodes. Ongoing efforts to address disparities in diabetes technology access are crucial for optimizing care and alleviating the burden on individuals with T1DM across racial backgrounds.
The crystal structure of dichlorido(η
6-p-cymene)(triphenylarsine)ruthenium(II), C28H29AsCl2Ru
Authors: Morerwa Zanele , Clayton Hadley S. 
Published: February 2025

Abstract
C28H29AsCl2Ru, monoclinic, P21/n (no. 14), a = 15.4135(9) Å, b = 9.2514(5) Å, c = 35.444(2) Å, β = 97.000(3)°, V = 5016.5(5) Å3, Z = 8, R

gt
(F) = 0.0537, wR
ref(F
2) = 0.1127, T = 100 K.
Copyright Societies and Musicians in the Democratic Republic of Congo: Enduring Infrastructures in Times of Decolonization?
Authors: Pouillard Véronique 
Published: February 2025

Abstract
This article examines the role of copyright societies in shaping the work of musicians in the Democratic Republic of the Congo during decolonization. The Belgian colonial authorities had transferred the Western system of intellectual property rights and collecting societies to Congo during the colonial period. Intellectual property dues granted specific revenues to Congolese artists until the late colonial period under a legal regime that was otherwise repressive for the colonized. At the same time, Kinshasa became one of the early music capitals on the African continent. First, this article outlines the firms and institutions that comprised the emerging record industry in Congo. Second, it quantifies the total dues for intellectual property rights paid to Congolese musicians during the late colonial and early postcolonial periods. Third, it examines ruptures and continuities with the emergence of new authors’ rights societies in Congo during the postcolonial era. Such systems also allowed for geographical extensions among the diasporas of Congolese musicians, especially in France and Belgium, supplementing the infrastructures in the Democratic Republic of the Congo. Fourth, it highlights the continuities in Congolese copyright societies and the influence of a long and complex period of decolonization on music infrastructures.
Normativität in der Ökonomik
Authors: Polk Andreas 
Published: February 2025

Zusammenfassung
Der Artikel erörtert die normativen Grundlagen der Ökonomik. Diese Fragen werden in der Literatur nur selten erörtert, zum Beispiel in Michael Sandels Diskussion über die moralischen Grenzen von Märkten oder in Forschung, die Verdrängungseffekte des Marktes auf moralisches Verhalten untersucht. Der Beitrag diskutiert die Vor- und Nachteile normativer Zurückhaltung in den Wirtschaftswissenschaften. Am Beispiel des individuellen Verhaltens in Zeiten des Klimawandels wird deutlich, dass die Ökonomik die ethische Dimension des menschlichen Verhaltens nicht ignorieren sollte. Dies ist insbesondere dann der Fall, wenn der ordnungspolitische Rahmen falsche Anreize setzt und dies zu Marktversagen führt.
Shifting from a ‘just’ to a ‘fair’ transition in environmental discourse: a case of old wine in a new bottle?
Authors: Manzella Pietro 
Published: February 2025

Abstract
This paper investigates the language used in certain institutional documents discussing the ‘just’ and ‘fair’ transitions, aiming to determine whether this lexical shift is merely nominal or reflects differences in the construction of these concepts. Specifically, two non-binding documents are considered: the International Labour Organization (ILO) Guidelines (2015) and the European Union (EU) Council Recommendation (2022). Using the Appraisal Framework, particularly the Judgement subsystem, the paper explores how these texts evaluate human behaviour and the ethical dimensions related to environmental transitions, addressing the following questions: How is this shift discursively framed in these documents? What are the potential implications of this terminological change in terms of stance-taking and reader reception regarding environmental issues? The findings reveal that while both the ILO Guidelines and the EU Recommendation emphasise the urgency of transitioning to greener economies, the ILO Guidelines advocate for a participatory ‘just’ transition, whereas the EU Recommendation promotes a more top-down ‘fair’ transition. This distinction aligns with Rawls’ theory of justice, with the ‘just’ transition reflecting a more inclusive approach.
Sidi Zin Archaeological Project: new investigations into the Acheulean and Middle Stone Age in Tunisia
Authors: Ben Arous Eslem , Aouadi Nabiha , Belhouchet Lotfi , Mekki Héla , Trabelsi Kaïs , Mabrouki Mosbah , Essid El Mabrouk , Fehri Noômène , Shao Qingfeng , Falguères Christophe , Lebreton Vincent , Roberts Patrick , Patalano Robert 
Published: February 2025

Abstract
The Sidi Zin Archaeological Project aims to bridge understanding of the Acheulean–Middle Stone Age transition in northern Tunisia, a relatively understudied region in the context of hominin evolution. The Sidi Zin locality will provide chronological, palaeoenvironmental, geomorphological and cultural insights into Acheulean and Middle Stone Age occupations in Tunisia.
Excavations at the Xiangranggounan site reveal changes in dwellings during the Late Bronze Age on the Qinghai-Tibet Plateau
Authors: Meng Qi , Han Fang , Lu Hongliang , Song Jixiang , Qiao Hong , Li Jiyuan , Xia Yanping , Du Zhanwei 
Published: February 2025

Abstract
Xiangranggounan is an intensively occupied settlement associated with the Kayue culture on the north-eastern Qinghai-Tibet Plateau. Excavations in 2022 and 2023 revealed five house types with clear stratigraphic relationships that help to expand current understanding of the evolution of prehistoric settlement patterns in harsh plateau environments.
Association of hyperuricemia with dietary patterns and alcohol consumption in the adult population. Results of the ESSE-RF epidemiological study
Authors: Karamnova N. S. , Shvabskaya O. B. , Rytova A. I. , Balanova Yu. A. , Evstifeeva S. E. , Imaeva A. E. , Kapustina A. V. , Kotova M. B. , Maksimov S. A. , Muromtseva G. A. , Shalnova S. A. , Drapkina O. M. 
Published: February 2025

Aim. To study the associations of hyperuricemia (HU) with dietary patterns and alcohol consumption in the Russian population.Material and methods. Representative samples of male and female population aged 25-64 years (17929 people, including 6593 men and 11336 women) from 13 Russian regions were examined. The response rate was ~80%. The dietary pattern was studied by the consumption rate of the main food groups. HU was diagnosed at a uric acid (UA) level >400 μmol/l for men and >360 μmol/l for women. The results are presented as odds ratio (OR) and 95% confidence interval (CI).Results. People with HU more often consume fish (men by 28% and women by 34%) (p<0,005), less often — sweets (by 22 and 21%, respectively) (p<0,001) and cheese (by 13 and 14%, respectively) (p<0,05). In the diet of individuals with HU, excess sugar consumption is lower by 19 and 23% in men and women, respectively (p<0,001). Women with HU also have 13% lower red meat consumption, 36% lower legume consumption, 28% higher poultry consumption (p<0,001) and 25% lower low-fat dairy products (p<0,05), as well as 15% lower animal fat use in cooking (p=0,008) compared to individuals without HU. Individuals with HU do not discontinue alcohol, but its consumption is lower than in individuals without HU. In men, the amount of alcohol consumed has a linear association with the UA level of and HU risk. In general, among male alcohol consumers, the risk of HU is 1,32 [1,13-1,54] (p=0,001). In men with low alcohol consumption, the risk of HU is 1,24 [1,05-1,45] (p=0,009), with moderate and high consumption — 1,61 [1,32-1,97] (p<0,001) and 1,64 [1,27-2,12] (p<0,001), respectively.Conclusion. The diet of individuals with HU differs significantly from the diet of individuals without HU, which is more pronounced among women. In men, the risk of HU increases linearly with the amount of alcohol consumed.
Associations of neighborhood infrastructure with cardiovascular diseases and their risk factors: results of the ESSE-RF-3 epidemiological study
Authors: Maksimov S. A. , Kotova M. B. , Shalnova S. A. , Balanova Yu. A. , Imaeva A. E. , Kutsenko V. А. , Evstifeeva S. E. , Kapustina A. V. , Muromtseva G. A. , Karamnova N. S. , Shvabskaya O. B. , Repkina T. V. , Gonoshilova T. O. , Kudryavtsev A. V. , Belova N. I. , Shagrov L. L. , Samotrueva M. A. , Yasenyavskaya A. L. , Bashkina O. A. , Glukhovskaya S. V. , Levina I. A. , Shirshova E. A. , Dorzhieva E. B. , Urbanova E. Z. , Borovkova N. Yu. , Kurashin V. K. , Tokareva A. S. , Ragino Yu. I. , Simonova G. I. , Khudyakova A. D. , Nikulin V. N. , Aslyamov O. R. , Khokhlova G. V. , Solovyova A. V. , Rodionov A. A. , Kryachkova O. V. , Shamurova Yu. Yu. , Mikhailov E. V. , Tarabrina Yu. O. , Ataev M. G. , Radzhabov M. O. , Gasanova Z. M. , Umetov M. A. , Khakuasheva I. A. , Elgarova L. V. , Yamashkina E. I. , Balykova L. A. , Usanova A. A. , Nikitina A. M. , Savvina N. V. , Spiridonova Yu. E. , Naumova E. A. , Yudin V. S. , Keskinov A. A. , Yudin S. M. , Kontsevaya A. V. , Drapkina O. M. 
Published: February 2025

Aim. To analyze the association of neighborhood infrastructure with cardiovascular diseases (CVDs) and their risk factors (RFs) in a representative all-Russian adult population sample.Material and methods. Data from the ESSE-RF3 study conducted in 2020-2022 in 15 Russia regions were used. The total sample included 28731 men and women aged 35-74 years. The neighborhood infrastructure was assessed using the Russian version of the (Neighborhood Environmental Walkability Scale (NEWS). The following CVDs and their risk factors were assessed: hypertension, obesity, hypercholesterolemia, alcohol abuse, smoking, diabetes, coronary artery disease, myocardial infarction, stroke, and cancer. Associations of disease outcomes with neighborhood infrastructure were assessed using logistic regression with adjustment for individual sociodemographic characteristics.Results. Population density, distance from infrastructure facilities to home, accessibility of infrastructure facilities, walkability and aesthetics of the area, as well as safety related to traffic and crime, are associated with CVDs and their risk factors. The greatest number of associations are noted with smoking, alcohol abuse, obesity, diabetes and hypertension.Conclusion. The study results confirm the need to take into account the neighborhood infrastructure when assessing cardiovascular risk, implementing preventive strategies and urban planning decisions.
Patients with atrial fibrillation after discharge from a multidisciplinary hospital: analysis of death risk and its causes based on 10-year follow-up data
Authors: Luk'yanov M. M. , Gomova T. A. , Martsevich S. Yu. , Shepel R. N. , Soplenkova A. G. , Smirnov A. A. , Valiakhmetov M. N. , Stepanova E. V. , Savishcheva A. A. , Drapkina O. M. 
Published: February 2025

Aim. To evaluate the outcomes of 10-year follow-up of patients with atrial fibrillation (AF) after hospitalization in various departments of a multidisciplinary hospital and to determine the most significant prognostic factors associated with a high death risk.Material and methods. In the outpatient registry RECVAZA-AF Tula after discharge from a multidisciplinary hospital, the outcomes for the period 2013-2024 (follow-up, 7,9±3,7 years) were assessed in 1159 patients with AF (age, 69,2±9,8 years; men, 48,0%). Information on fatal outcomes was obtained from the Regional Information System of the Tula Oblast.Results. Over 10 years, 509 (43,9%) patients with AF died. The highest proportion of deaths was among those who had stroke and myocardial infarction (MI) — 55,1 and 52,9%, respectively, with permanent AF (51,4%), at the age of ≥80 years (66,4%). High all-cause and cardiovascular death risk was associated with the following factors: age (hazard ratio (HR)=1,04 and HR=1,06; p<0,001); prior stroke (HR=1,38; p=0,008 and HR=1,69; p=0,001); permanent AF (HR=1,36; p=0,02 and HR=1,61; p=0,009); diabetes (HR=1,67; p<0,001 and HR=1,43; p=0,015); systolic blood pressure <110 mm Hg (HR=1,96; p=0,001 and 1,82; p=0,035). Chronic obstructive pulmonary disease and low hemoglobin levels were associated with a high all-cause mortality only (HR=2,02; p=0,001 and HR=1,49; p=0,018), and prior MI was associated with a cardiovascular death risk only (HR=1,32; p=0,043). The proportion of deaths was lowest among those discharged from cardiology departments (excluding emergency cardiology) — 33,7% and internal medicine departments — 37,0%, and the highest among those discharged from neurology departments — 54,9%, emergency cardiology departments — 56,7%, and surgical departments — 47,9%.Conclusion. Over 10 years after discharge from a multidisciplinary hospital, 43,9% of patients with AF died. The mortality rate was highest in AF with prior stroke and MI, with permanent AF, and at an age of ≥80 years. Prognostically unfavorable factors also included diabetes, chronic obstructive pulmonary disease, low hemoglobin levels, and systolic blood pressure <110 mm Hg. The lowest mortality rate was among patients discharged from cardiology (excluding emergency cardiology) and internal medicine departments, and the highest one was among those discharged from emergency cardiology, neurology, and surgery departments.
Myocardial ischemia as a cause of paroxysmal dyspnea in patients with stable coronary artery disease
Authors: Yarmedova S. F. , Yavelov I. S. , Drapkina O. M. 
Published: February 2025

Aim. To determine the potential of diagnosing myocardial ischemia as a cause of paroxysmal dyspnea in patients with stable coronary artery disease (CAD) before an in-depth examination.Material and methods. This cross-sectional single-center study included stable patients with an established diagnosis of CAD and complaints of paroxysmal dyspnea, who were undergoing inpatient treatment in the cardiology department (n=101). All study participants underwent treadmill stress echocardiography to detect transient myocardial ischemia. Complaints, anamnesis data, results of physical examination, laboratory tests, electrocardiography (ECG) and transthoracic cardiac ultrasound examination, including tissue Doppler were analyzed.Results. Myocardial ischemia according to stress echocardiography was detected in 36 (35,6%) patients. According to multivariate analysis, independent signs indicating myocardial ischemia as a cause of dyspnea were the duration of dyspnea attack (odds ratio (OR) 1,43, 95% confidence interval (CI): 1,06-1,92; p=0,02), typical angina (OR 5,57, 95% CI: 1,17-26,63; p=0,031), pathological Q wave (OR 6,66, 95% CI: 2,03-21,85; p=0,002), right atrium volume (OR 0,96, 95% CI: 0,92-1,00; p=0,045) and lateral e` (OR 1,26, 95% CI: 1,01-1,57; p=0,038). When combining these variables into a single regression equation, the area under the characteristic curve (ROC curve) was 0,83, 95% CI: 0,750,91; sensitivity, specificity, positive and negative predictive value for the optimal cutoff point were 88,9, 72,6, 57,1 and 91,1%, respectively. In turn, for the point scale created using these variables, the area under the ROC curve was 0,79 with 95% CI: 0,70-0,88; sensitivity, specificity, positive and negative predictive value were 83,3 and 64,6, 56,6 and 87,5%, respectively. There was no significant difference in the areas under the ROC curve for regression equation and point scale (p=0,355).Conclusion. The presence of myocardial ischemia as a cause of paroxysmal dyspnea in patients with stable CAD can be predicted based on the data available in real-world practice, including the characteristics of clinical manifestations, resting ECG, and transthoracic cardiac ultrasound.
Remote outcomes in patients with cardiovascular diseases in outpatient practice: data from a 10-year follow-up within the RECVAZA registry
Authors: Luk'yanov M. M. , Martsevich S. Yu. , Yakushin S. S. , Andreenko E. Yu. , Pereverzeva K. G. , Kozminsky A. N. , Pravkina E. A. , Klyashtorny V. G. , Drapkina O. M. 
Published: February 2025

Aim. To evaluate outcomes over 10-year follow-up and risks of adverse events in patients with cardiovascular disease (CVD) within the outpatient registry.Material and methods. In the RECVAZA outpatient registry based on 3 Ryazan clinics, 3690 patients with CVD (age, 66,1±12,9 years; men, 28,0%) were observed. For 2012-2023 (follow-up, 8,2±3,3 years), the following outcomes were assessed: death, myocardial infarction (MI), stroke, hospitalization for CVD. Information on outcomes was obtained from medical records, surveys, electronic databases.Results. Over 10 years, 1595 patients (43,2%) died, 51% of whom died from CVD and 12% from cancer. The highest proportion of deaths was among patients with prior stroke (69,7%) and MI (61,5%) before inclusion in the registry, a combination of hypertension (HTN), coronary artery disease (CAD), heart failure (HF), atrial fibrillation (AF) — 79%, age ≥80 years — 85,9%. The highest all-cause and cardiovascular death risk was associated with age (hazard ratio (HR))=1,06 and HR=1,07; p<0,001); male sex (HR=1,70 and HR=1,62; p<0,001); prior stroke (HR=1,86 and HR=2,13; p<0,001); type 2 diabetes (HR=1,55 and HR=1,67; p<0,001); low hemoglobin level (HR=1,66 and HR=1,72; p<0,001); smoking (HR=1,51; p=0,001 and HR=1,72; p=0,003), respectively. The risk of MI was associated to the greatest extent with male sex and prior MI (HR=1,77 and HR=2,61; p<0,001), while the risk of stroke — with AF and prior stroke (HR=1,65 and 3,78; p<0,001) and systolic blood pressure <110 mm Hg (HR=2,72; p=0,01). Hospitalization for CVD no more than once per 2 years was associated with a lower risk of death (1,9 times), a higher frequency — with a higher risk (1,6 times).Conclusion. Over 10-year follow-up, 43,2% of patients with CVD died. The highest death rate was in patients with a history of stroke and MI, diabetes, with a combination of HTN, CAD, HF and AF, low hemoglobin levels. Hospitalization for CVD no more than once per 2 years was prognostically favorable, but with a higher frequency it was associated with an increased risk of death.
Transient left bundle branch block in a young patient with a myocardial bridge: a case report
Authors: Novokhatskaya E. A. , Limonova A. S. , Ershova A. I. , Drapkina O. M. 
Published: February 2025

Introduction. Transient complete left bundle branch block (LBBB) may occur against the background of various conditions, including coronary artery disease, cardiomyopathy of various origins, valvular diseases, heart rate abnormalities, acute pulmonary embolism, anesthesia, intrathoracic pressure changes, chest trauma, tumors, etc. Newly diagnosed complete LBBB in combination with the corresponding clinical manifestations is regarded as an acute coronary syndrome and requires immediate hospitalization.Results. A case of asymptomatic transient complete LBBB in a 36-yearold man without hemodynamically significant coronary atherosclerosis, with a myocardial bridge in the middle segment of left anterior descending artery with stenosis of 30%.Conclusion. Taking into account the paraclinical data, we studied the probability of transient complete LBBB against the background of left anterior descending artery myocardial bridging, as well as the probability of tachycardia-induced transient LBBB.
Properties of incompletely penetrant cardiomyopathy-associated genome variants
Authors: Zaychenoka M. , Ramenskiy V. E. , Kiseleva A. V. , Bukaeva A. A. , Ershova A. I. , Meshkov A. N. , Drapkina O. M. 
Published: February 2025

Aim. To study and describe the properties of nucleotide sequence variants with incomplete penetrance associated with various cardiomyopathies.Material and methods. The study used penetrance data of genome variants from a previously published study. The variants were annotated using Ensembl VEP, as well as information from the gnomAD, ClinVar, and dbNSFP databases.Results. For all datasets, significant correlations of penetrance (Spearman correlation coefficient from -0,75 to -0,90) with the population frequency of variants in the gnomAD database were obtained. Variants with low penetrance values were enriched in variants of unknown significance. Most of the low-penetrance variants were missense substitutions. High-penetrance values were enriched in variants classified as pathogenic, most of which were frameshift variants. Significant correlations were obtained with weights calculated by different computational methods for predicting variant pathogenicity. For all data sets, the penetrance value was significantly correlated with the predictions of four following methods: CADD, BayesDel with and without frequency, and ClinPred.Conclusion. For the first time, a relationship of the population frequency, type and pathogenicity prediction of a variant with the penetrance value was shown.