bluuebunny/crossref_metadata_2025_split huggingface dataset:
E-cadherin interacts with EGFR resulting in hyper-activation of ERK in multiple models of breast cancer
Authors: Russo Gabriella C. , Crawford Ashleigh J. , Clark David , Cui Julie , Carney Ryan , Karl Michelle N. , Su Boyang , Starich Bartholomew , Lih Tung-Shing , Kamat Pratik , Zhang Qiming , Wu Pei-Hsun , Lee Meng-Horng , Leong Hon S. , Rebecca Vito W. , Zhang Hui , Wirtz Denis 
Published: November 2020

ABSTRACTThe loss of the intercellular adhesion molecule E-cadherin is a hallmark of the epithelial- mesenchymal transition (EMT), during which tumor cells transition into an invasive phenotype. Accordingly, E-cadherin has long been considered a tumor suppressor gene. Using novel multi-compartment spheroids and multiplein vivomodels, we show that E-cadherin promotes a hyper-proliferative phenotype in breast cancer cells via interaction with the transmembrane receptor EGFR. This interaction results in the activation of the MEK/ERK signaling pathway, leading to a significant increase in proliferation via the activation of transcription factors including c-Fos. Pharmacological inhibition of MEK activity in E-cadherin positive breast cancer cells significantly decreases both tumor growth and macro-metastasisin vivo. This work provides evidence for a novel role of E-cadherin in breast tumor growth and identifies a potential new target to treat hyper-proliferative E-cadherin-positive breast tumors.
Psychological safety, meaningfulness and empowerment as predictors of employee well-being: a mediating role of promotive voice
Authors: Hasan Fouzia , Kashif Muhammad 
Published: November 2020

PurposeThe core aim of this study is to explore how psychological safety, psychological meaningfulness and psychological empowerment predict psychological well-being in a mediating role of promotive voice.Design/methodology/approachA cross-sectional survey is employed to collect data from 456 front-line employees (FLEs) working in the banking sector of Pakistan. The collected data were analyzed utilizing the structural equation modelling (SEM) technique.FindingsThe relationship between psychological safety and empowerment is significant. The results support the direct and mediating role of promotive voice to predict psychological well-being among frontliners. Interestingly, the mediation of promotive voice to predict the relationship between psychological meaningfulness and psychological well-being is not supported.Practical implicationsThe managers should delegate authority to FLEs working at the front end. Moreover, voicing should be a delightful experience for employees. The management should listen to them carefully and also update the staff about the outcomes of suggestions rendered by them. Finally, rewarding employees can encourage promotive voicing among FLEs.Originality/valueThe psychological safety as an antecedent to promotive voice, promotive voice as a predictor of psychological well-being and the collectivist country context of Pakistan are unique products of this study.
Facial expression recognition based on bidirectional gated recurrent units within deep residual network
Authors: Shen Wenjuan , Li Xiaoling 
Published: November 2020

Purposerecent years, facial expression recognition has been widely used in human machine interaction, clinical medicine and safe driving. However, there is a limitation that conventional recurrent neural networks can only learn the time-series characteristics of expressions based on one-way propagation information.Design/methodology/approachTo solve such limitation, this paper proposes a novel model based on bidirectional gated recurrent unit networks (Bi-GRUs) with two-way propagations, and the theory of identity mapping residuals is adopted to effectively prevent the problem of gradient disappearance caused by the depth of the introduced network. Since the Inception-V3 network model for spatial feature extraction has too many parameters, it is prone to overfitting during training. This paper proposes a novel facial expression recognition model to add two reduction modules to reduce parameters, so as to obtain an Inception-W network with better generalization.FindingsFinally, the proposed model is pretrained to determine the best settings and selections. Then, the pretrained model is experimented on two facial expression data sets of CK+ and Oulu- CASIA, and the recognition performance and efficiency are compared with the existing methods. The highest recognition rate is 99.6%, which shows that the method has good recognition accuracy in a certain range.Originality/valueBy using the proposed model for the applications of facial expression, the high recognition accuracy and robust recognition results with lower time consumption will help to build more sophisticated applications in real world.
Evaluating ṣukūk investment intentions in Pakistan from a social cognitive perspective
Authors: Khan Safeer Ullah , Khan Ikram Ullah , Khan Ismail , Din Saif Ud , Khan Abid Ullah 
Published: November 2020

Purpose
This study aims to evaluate cognitive, personal and environmental factors affecting investors’ behavioral intentions (BI) to invest in ṣukūk (Islamic investment certificates) in Pakistan.

Design/methodology/approach
Data from 462 participants were collected through survey-questionnaires by using the convenient sampling technique. Hypothesized proposed relationships among the constructs were examined by applying the structural equation modeling (SEM) technique through smart partial least squares.

Findings
Compatibility, internal influence, external influence and intrinsic motivation were found to be significant predictors of investors’ BI to invest in ṣukūk. In addition, it was found that the religious aspect not only affects investors’ BI positively but also works as a moderator in the relationships between BI and both internal and external influence.

Practical implications
The results are quite helpful for ṣukūk issuers and regulators to consider cognitive, personal and environmental factors that might enhance the adoption of ṣukūk, especially among Muslim investors.

Originality/value
This study is among the few research studies that shed light on investors’ BI to invest in ṣukūk. Using social cognitive theory, the study investigates the cognitive, personal and environmental factors influencing ṣukūk adoption, which were previously unexplored. In addition, this is the first study that unveils the influential factors of ṣukūk adoption in Pakistan, a Muslim-majority country.
Does PMS influence the strategy pillars: OPP relationship? Evidence from HEIs in Indonesia
Authors: Soewarno Noorlailie , Tjahjadi Bambang , Anmariska Farah 
Published: November 2020

PurposeThis study aims to investigate whether strategy pillars have a positive direct effect on organizational productivity performance (OPP) in the Indonesian HEI (Higher Education Institutions) research setting and, if so, whether the effect is mediated by a performance management system (PMS).Design/methodology/approachThis study used quantitative research employing partial least square structural equation modeling (PLS-SEM) to test the hypotheses. A mediation model of the research framework was developed to investigate the mediating role of PMS.FindingsUsing a sample of 182 Indonesian HEI managers, the results indicate that strategy pillars have a positive effect on OPP. Further analysis shows that PMS partially mediates the strategy pillar–OPP relationship.Research limitations/implicationsThis study has limitations. Firstly, the sample size used was relatively small and this may raise the issue of generalization. Secondly, it used a Likert scale and therefore may raise the issue of judgment bias. Lastly, this study is context-specific for Indonesia and caution should be used when generalizing it to other countries.Practical implicationsTo enhance the HEIs productivity performance, the HEI managers should develop strong strategy pillars for the purpose of effective strategy formulation and execution.Social implicationsThis study provides a model showing how to improve the HEIs productivity performance by employing strategy pillars and a PMS. The better the performance of the HEIs, the better the quality of life of society in the era of the knowledge economy.Originality/valueStrategy pillars have rarely been researched. This study is therefore one of the few studies on strategy pillars. This study also provides new elements related to measuring strategy pillars, PMS and OPP in the context of HEIs in Indonesia as an emerging economy.
Students’ attitude toward sustainability and humanitarian engineering education using project-based and international field learning pedagogies
Authors: Ngo Truc Thanh , Chase Bradley 
Published: November 2020

Purpose
Environmental sustainability and social contexts are becoming increasingly important concepts. The infusion of sustainability and humanitarian engineering (HE) into the academic core curriculum is often challenging. This study aims to provide an understanding of students’ perceptions and attitudes toward the incorporation of active learning of sustainability and humanitarian concepts into engineering education.

Design/methodology/approach
A project-based sustainability course was developed and offered to engineering undergraduates. A HE international field experience was also provided to students as an extracurricular activity. Pre- and post-surveys were conducted to assess students’ perceptions and attitudes toward sustainability and HE project learning experience. An analysis of variance (ANOVA) was performed to determine the statistical significance of the results and demographic influences on students’ experiences.

Findings
Both project-based and international field learning experiences positively influenced the students’ perceptions of sustainable practices, social change and appreciation of the engineering profession. Multidisciplinary learning also helped students become more motivated, engage in sustainability-promoted activities and community work and improve their social interactions. Students gained practical engineering skills that they did not typically receive in traditional classroom settings and recognized the global and social responsibilities that are core to sustainable development education.

Originality/value
The study demonstrates a mixed undergraduate educational model in which students acquired sustainability concepts through a project-based engineering course and practiced social responsibility through international HE projects. The findings help engineering educators understand students’ perceptions toward sustainability and HE, providing insight into effective curriculum design and strategic inclusion of social responsibility in traditional engineering education.
Foreign inflows and economic growth in Pakistan: some new insights
Authors: Tahir Muhammad , Jan Ahmad Ali , Shah Syed Quaid Ali , Alam Md Badrul , Afridi Muhammad Asim , Tariq Yasir Bin , Bashir Malik Fahim 
Published: November 2020

PurposeThe purpose of this paper is to explore the contending role of important external inflows on the economic growth of Pakistan economy. The main purpose behind focusing on Pakistan is that it is receiving significant inflows from different international sources such as International Monetary Fund, World Bank and Asian Development Bank.Design/methodology/approachThe study adopted the autoregressive distributed lag cointegration approach for the purpose of exploring the long-run cointegrating relationship among the variables. As Pakistan Government had been implementing some major liberalization policies during 1990s, data from 1976 to 2018 is used to estimate the specified models to reflect the impact of the surge of foreign inflows occurring from that time. In addition, error correction model is estimated for examining the short-run relationships.FindingsThe findings revealed the significant role played by different inflows in accelerating the economic growth. According to results, in the long run, all inflows, for example, Foreign direct investment (FDI), debt, official developdment assistance and remittances, have influenced significantly and positively the economic growth. The two control variables such as inflation and employment level included in the model have also played their expected role in the growth process. In the short run, some of the variables such as remittances, FDI and inflation rate have lost their significance level while for debt, aid and employment level, the signs of their coefficients become reversed.Practical implicationsBased on the findings, the study suggests the policymakers of Pakistan economy to liberalize the economy and attract more inflows from the external sources to accelerate economic growth.Originality/valueTo the best of the authors’ knowledge, this is the first comprehensive empirical study on the role of foreign inflows in the process of economic growth in the context of Pakistan economy.
Being an entrepreneur post-COVID-19 – resilience in times of crisis: a systematic literature review
Authors: Portuguez Castro May , Gómez Zermeño Marcela Georgina 
Published: November 2020

PurposeThe COVID-19 pandemic has had an uncertain impact on the global economy, especially for entrepreneurs and small and medium-sized enterprises that have suffered significant consequences. However, resilience has emerged as an entrepreneurial skill that allows companies to adapt and grow stronger in the face of challenges. Therefore, this paper conducted a literature review to identify the factors that comprise resilience to strengthen training programs for entrepreneurial skills. This study aims to lead to future empirical studies that will provide more understanding and equip professionals with the skills to adapt to crises.Design/methodology/approachA systematic literature review was performed, analyzing studies related to entrepreneurship, resilience and crises. In total, 30 empirical studies were analyzed to determine the facts of the crises, the methodologies used and the actions taken to address them.FindingsThe review identified resilience factors such as attitudes adopted toward the crisis, the characteristics of the business and the entrepreneur, the relationships with institutions, human and social capital and strategic management. These factors can be considered in training programs for resilient entrepreneurs and by the different actors in the entrepreneurial ecosystem, including the universities and public policymakers, who support them.Originality/valueThis study provides a literature review that focuses on identifying the resilience factors of entrepreneurs who confronted past crises to know how to apply them to overcome the current situation and contribute to post-COVID-19 entrepreneurship. This paper hopes that the findings motivate others to conduct further empirical studies on entrepreneurship and resilience in times of crisis, especially in developing countries and emerging economies.
Transformational leadership and employee outcomes: the mediating role of psychological empowerment
Authors: Saira Saira , Mansoor Sadia , Ali Muhammad 
Published: November 2020

PurposeThe purpose of this study is to empirically test the mediating effect of psychological empowerment in the relationship between transformational leadership and two employee outcomes: organizational citizenship behavior and turnover intention.Design/methodology/approachThe data were collected from 316 employees working in the textile industry to empirically test the proposed model.FindingsThe findings of this study indicate that psychological empowerment mediates the relationship between transformational leadership and both employee outcomes of organizational citizenship behavior and turnover intention.Research limitations/implicationsThis study suggests that organizations aiming to minimize turnover intention among employees should develop a transformational leadership style at the managerial level to enhance psychological empowerment among employees, which, in turn, will also improve organizational citizenship behavior.Originality/valueThis study proposes and tests the indirect effect of transformational leadership on organizational citizenship behavior and turnover intention via psychological empowerment.
What matters to ownership structure? Evidence from pre- and post-global financial crisis in an emerging market
Authors: Panda Brahmadev , Kumar Gaurav 
Published: November 2020

PurposeThe purpose of this paper is to ascertain determining factors of ownership concentration and institutional portfolio ownership in the listed firms of an emerging market during pre-crisis and post-crisis periods and find variations in determining factors between the two varying market conditions.Design/methodology/approachThis paper considers 316 listed firms for the pre-crisis period and 408 firms for the post-crisis period, from the NIFTY-500. Pre-crisis period ranges from FY2000-01 to FY2007-08 and post-crisis period ranges from FY2009-10 to FY2016-17. Two-step GMM is utilized to test the hypotheses by controlling the unobserved heterogeneity and endogeneity issues.FindingsHigher investment and stock market growth leads to ownership dispersion in both the market conditions. Industry information asymmetry leads to dispersion in pre-crisis, while improves concentration in post-crisis phase. Firm size, legal environment and economic growth are found to be a positive determinant of institutional ownership irrespective of market conditions. Institutional investment proliferates with higher stock liquidity and PE ratio, while declines with augmented firm risk, current ratio and stock market turnover during post-crisis phase.Practical implicationsPolicymakers should construct a robust legal environment and focus to improve economic conditions to boost institutional ownership. Corporate executives should concentrate to increase stock liquidity and earnings of the firms, and lower market risk to draw more institutional portfolio investments.Originality/valueThis study would enrich emerging governance literature since studies on the determining factors of ownership holdings are limited in the emerging world. It adds novelty by capturing two different market conditions such as pre-crisis and post-crisis phases to obtain the time-dependent and time-independent determinants. It adds uniqueness by considering the determinants of institutional ownership, which is scarce in ownership studies.
A systematic review of current approaches to managing demand and waitlists for mental health services
Authors: Thomas Kerry A. , Schroder Annelise M. , Rickwood Debra J. 
Published: November 2020

PurposeTimely access to effective treatment is a primary goal for mental health services; however, when demand exceeds available resources, services may place clients on a waitlist or restrict services. This paper aims to identify approaches used by mental health services to manage service demand and waitlists.Design/methodology/approachA review of research literature between 2009 and 2019 was conducted using the Medline, PsycINFO, CINAHL, Embase and Cochrane databases. Articles were screened and assessed against inclusion criteria and the methodological quality of included studies was assessed using the Mixed Methods Appraisal Tool.FindingsIn total, 20 articles were located that met the inclusion criteria. Five demand management approaches were identified, namely, walk-in models, triage processes, multi-disciplinary care, patient-led approaches and service delivery changes.Research limitations/implicationsThis review identifies effective approaches that services can consider adapting to their local setting; however, further research is needed to demonstrate the clinical effectiveness of services provided under these models.Originality/valueThis review makes a valuable contribution to mental health care service delivery by detailing the strategies that services have adopted to manage demand and, where available, comparative outcomes with traditional service delivery models.
Recovery of the microstructural changes of different duplex stainless steel alloys
Authors: Khoshnaw Fuad , Delaunois Fabienne , Vitry Veronique 
Published: November 2020

PurposeTo find out the optimum heat treatments to recover the microstructural changes of stainless steel alloys.Design/methodology/approachA total of four alloys were used in this study: two duplex stainless steel (DSS) alloys type 2304 and 2205, super DSS (SDSS) type 2507 and austenitic stainless steel alloy type 316 L. The alloys were heated to different temperatures, 750, 850, 950 and 1,050°C, for three different times, 10 min, 1 and 4 h.FindingsThe microstructural investigations showed that 2205 and 2507 behaved similarly in recovering their microstructures, especially in terms of the ferrite:austenite ratio within specific heat treatments and changing the hardness values. The results indicated that the microstructure of both alloys started to change above 750°C, the largest changes were shown at 850 and 950°C as the lowest ferrite content (FC%) was recorded at 850°C for both alloys. However, the microstructures of both alloys started to recover at 1,050°C. The reduction in the hardness values was attributed to the formation of new ferrite grains, free of residual stresses. On the other hand, the microstructure of the alloy type 2304 was stable and did not show large changes due to the applied heat treatments, similarly for austenitic alloy except showing chromium (Cr) carbide precipitation.Originality/valueFinding the exact heat treatments, temperature and time to recover the microstructural changes of DSS alloys.
Anthropological understanding of culture – the key for designing Romani housing
Authors: Grbić Milena , Dulić Olivera , Aladžić Viktorija 
Published: November 2020

Purpose
This paper aims to demonstrate a possible way in which cultural elements of minorities, in the specific case of the Romani, can be researched and operationalized in certain guidelines for designing housing intended for these groups. The paper was inspired by a constant failure of the present practice of solving the socially vulnerable Romani housing problems, namely, previous attempts have only achieved a negative outcome that, besides the partial satisfaction of urgent housing needs, does not respect the specificities of the Romani culture and lifestyle. The negative result has once again displaced this subject outside of the designing expertise and demands new examinations of strategical principles that precede the solving of the Romani housing question.

Design/methodology/approach
The authors create a methodological turn from the humanistic determination of the term culture towards the anthropological one, forming a clear methodological position of accessing the Romani culture. To test this approach on Romani settlements in Belgrade, this study used on-site observations of everyday life and informal interviews with residents.

Findings
As a practical result, this paper presents an operational knowledge base about Romani housing with design recommendations. In the social sense, this knowledge contributes to the scientific description and explanation of the characteristics of Roma housing. In a wider sense, this paper has the potential to shed light on similar problems of minorities that are present outside of the national borders of Serbia.

Originality/value
The topic of Romani housing is insufficiently researched, especially in the region of the Western Balkans. For this reason, the present study and the obtained results represent a significant contribution to scientific knowledge in this field.