bluuebunny/crossref_metadata_2025_split huggingface dataset:
The visible skeleton 2.0: phenotyping of cartilage and bone in fixed vertebrate embryos and foetuses based on X-ray microCT
Authors: Gabner Simone , Böck Peter , Fink Dieter , Glösmann Martin , Handschuh Stephan 
Published: May 2020

ABSTRACT
For decades, clearing and staining with Alcian Blue and Alizarin Red has been the gold standard to image vertebrate skeletal development. Here, we present an alternate approach to visualise bone and cartilage based on X-ray microCT imaging, which allows the collection of genuine 3D data of the entire developing skeleton at micron resolution. Our novel protocol is based on ethanol fixation and staining with Ruthenium Red, and efficiently contrasts cartilage matrix, as demonstrated in whole E16.5 mouse foetuses and limbs of E14 chicken embryos. Bone mineral is well preserved during staining, thus the entire embryonic skeleton can be imaged at high contrast. Differences in X-ray attenuation of ruthenium and calcium enable the spectral separation of cartilage matrix and bone by dual energy microCT (microDECT). Clearing of specimens is not required. The protocol is simple and reproducible. We demonstrate that cartilage contrast in E16.5 mouse foetuses is adequate for fast visual phenotyping. Morphometric skeletal parameters are easily extracted. We consider the presented workflow to be a powerful and versatile extension to the toolkit currently available for qualitative and quantitative phenotyping of vertebrate skeletal development.
Vessel-derived angiocrine IGF1 promotes Meckel's cartilage proliferation to drive jaw growth during embryogenesis
Authors: Marchant Ceilidh , Anderson Peter , Schwarz Quenten , Wiszniak Sophie 
Published: May 2020

ABSTRACT
Craniofacial development is a complex morphogenic process that requires highly orchestrated interactions between multiple cell types. Blood vessel-derived angiocrine factors are known to promote proliferation of chondrocytes in Meckel's cartilage to drive jaw outgrowth, however the specific factors controlling this process remain unknown. Here, we use in vitro and ex vivo cell and tissue culture, as well as genetic mouse models, to identify IGF1 as a novel angiocrine factor directing Meckel's cartilage growth during embryonic development. We show that IGF1 is secreted by blood vessels and that deficient IGF1 signalling underlies mandibular hypoplasia in Wnt1-Cre; Vegfafl/fl mice that exhibit vascular and associated jaw defects. Furthermore, conditional removal of IGF1 from blood vessels causes craniofacial defects including a shortened mandible, and reduced proliferation of Meckel's cartilage chondrocytes. This demonstrates a crucial angiocrine role for IGF1 during craniofacial cartilage growth, and identifies IGF1 as a putative therapeutic for jaw and/or cartilage growth disorders.
Inflated citations and metrics of journals discontinued from Scopus for publication concerns: the GhoS(t)copus Project
Authors: Cortegiani Andrea , Ippolito Mariachiara , Ingoglia Giulia , Manca Andrea , Cugusi Lucia , Severin Anna , Strinzel Michaela , Panzarella Vera , Campisi Giuseppina , Manoj Lalu , Gregoretti Cesare , Einav Sharon , Moher David , Giarratano Antonino 
Published: May 2020

Background: Scopus is a leading bibliometric database. It contains the largest number of articles cited in peer-reviewed publications. The journals included in Scopus are periodically re-evaluated to ensure they meet indexing criteria and some journals might be discontinued for publication concerns. These journals remain indexed and can be cited. Their metrics have yet to be studied. This study aimed to evaluate the main features and metrics of journals discontinued from Scopus for publication concerns, before and after their discontinuation, and to determine the extent of predatory journals among the discontinued journals. Methods: We surveyed the list of discontinued journals from Scopus (July 2019). Data regarding metrics, citations and indexing were extracted from Scopus or other scientific databases, for the journals discontinued for publication concerns. Results: A total of 317 journals were evaluated. Ninety-three percent of the journals (294/318) declared they published using an Open Access model. The subject areas with the greatest number of discontinued journals were Medicine (52/317; 16%), Agriculture and Biological Science (34/317; 11%), and Pharmacology, Toxicology and Pharmaceutics (31/317; 10%). The mean number of citations per year after discontinuation was significantly higher than before (median of difference 64 citations, p<0.0001), and so was the number of citations per document (median of difference 0.4 citations, p<0.0001). Twenty-two percent (72/317) were included in the Cabell’s blacklist. The DOAJ currently included only 9 journals while 61 were previously included and discontinued, most for 'suspected editorial misconduct by the publisher'. Conclusions: The citation count of journals discontinued for publication concerns increases despite discontinuation and predatory behaviors seemed common. This paradoxical trend can inflate scholars’ metrics prompting artificial career advancements, bonus systems and promotion. Countermeasures should be taken urgently to ensure the reliability of Scopus metrics both at the journal- and author-level for the purpose of scientific assessment of scholarly publishing.
Optimised patient information materials and recruitment to a study of behavioural activation in older adults: an embedded study within a trial
Authors: Knapp Peter , Gilbody Simon , Holt Janet , Keding Ada , Mitchell Natasha , Raynor David K. , Silcock Jonathan , Torgerson David J. 
Published: May 2020

Background: Printed participant information about randomised controlled trials is often long, technical and difficult to navigate. Improving information materials is possible through optimisation and user-testing, and may impact on participant understanding and rates of recruitment. Methods: A study within a trial (SWAT) was undertaken within the CASPER trial. Potential CASPER participants were randomised to receive either the standard trial information or revised information that had been optimised through information design and user testing. Results: A total of 11,531 patients were randomised in the SWAT. Rates of recruitment to the CASPER trial were 2.0% in the optimised information group and 1.9% in the standard information group (odds ratio 1.027; 95% CI 0.79 to 1.33; p=0.202). Conclusions: Participant information that had been optimised through information design and user testing did not result in any change to rate of recruitment to the host trial. Registration: ISRCTN ID ISRCTN02202951; registered on 3 June 2009.
„Demokracja organiczna” Alaina de Benoista jako alternatywa dla globalistycznej demokracji liberalnej
Authors: Bielawski Paweł 
Published: May 2020

Alain de Benoist’s ‘Organic Democracy’ as an Alternative to the Globalist Liberal Democracy
The topic of the article is the concept of organic democracy, as envisioned by Alain de Benoist. The French writer is critical of modern liberal democracy – he believes it is a fundamentally flawed system which should be reviewed. He proposes an alternative “organic democracy”, an illiberal form of democracy. The article briefly outlines the development of democracy in Europe and then describes the original Athenian democracy. Subsequently, the paper describes in depth the differences between the principles of representation and participation, and then proceeds to outline the relations between equality and homogeneity in democracy. Afterward, Benoist’s critique of liberal democracy is outlined and is situated in the context of Benoist’s body of work. The article concludes with a critical review of the concept of organic democracy.
Dynamic Inventory Control with Stockout Substitution and Demand Learning
Authors: Chen Boxiao , Chao Xiuli 
Published: May 2020

We consider an inventory control problem with multiple products and stockout substitution. The firm knows neither the primary demand distribution for each product nor the customers’ substitution probabilities between products a priori, and it needs to learn such information from sales data on the fly. One challenge in this problem is that the firm cannot distinguish between primary demand and substitution (overflow) demand from the sales data of any product, and lost sales are not observable. To circumvent these difficulties, we construct learning stages with each stage consisting of a cyclic exploration scheme and a benchmark exploration interval. The benchmark interval allows us to isolate the primary demand information from the sales data, and then this information is used against the sales data from the cyclic exploration intervals to estimate substitution probabilities. Because raising the inventory level helps obtain primary demand information but hinders substitution demand information, inventory decisions have to be carefully balanced to learn them together. We show that our learning algorithm admits a worst-case regret rate that (almost) matches the theoretical lower bound, and numerical experiments demonstrate that the algorithm performs very well. This paper was accepted by J. George Shanthikumar, big data analytics.
The Effects of Menu Costs on Retail Performance: Evidence from Adoption of the Electronic Shelf Label Technology
Authors: Stamatopoulos Ioannis , Bassamboo Achal , Moreno Antonio 
Published: May 2020

We use the adoption of electronic shelf labels (ESLs) by an international grocery retailer in 2015 to identify the effects of physical menu costs (i.e., labor and material costs of price adjustment) on retail performance. We find that the installation of ESLs increased gross margins substantially, which implies profit gains that go far beyond labor cost savings. We also explore the mechanism behind this effect. We find that the lift in gross margins was associated with an increase in quantity sold and a decrease in price per unit sold, and that the lift primarily came from low-shelf life product categories. Moreover, we find that more and smaller price changes occurred with ESLs. These additional price changes were mostly price decreases, and they were dispersed in time. Our findings are consistent with reductions in both variable and fixed menu costs (i.e., both costs that scale with the number of products affected and costs that do not). This paper was accepted by Vishal Gaur, operations management.
Impact of family history risk assessment on surgical decisions and imaging surveillance at breast cancer diagnosis
Authors: Jones S , Turton P , Achuthan R 
Published: May 2020

Introduction In June 2013, the National Institute for Health and Care Excellence (NICE) published guidance on the management of women with a family history (FH) of breast cancer (BC) and a personal diagnosis of BC. When diagnosed with BC, pressure of timely treatment takes priority and there is potential for a significant FH to be overlooked. This can affect treatment options and follow-up imaging (FUI) surveillance. Methods The practice in our breast unit was compared with the NICE guidance with regard to arranging appropriate FUI and referral to the genetics team for women diagnosed with BC with a FH of BC. Data were obtained retrospectively on 200 women with BC, identified from the breast multidisciplinary team meetings from January to March 2014. Initial audit showed poor compliance with recording of FH. A standardised history taking proforma was produced for clinic use. A re‐audit was conducted on a further 200 women between May and July 2016. Results In the initial audit, FH was taken in 151 women (76%) compared with 174 women (87%) in the re‐audit. Thirty-seven women (25%) were thought to be of moderate risk (MR) or high risk (HR) based on FH in the first audit. Re‐audit identified 35 women (20%) with MR or HR FH. Under half (43%) of the women of HR were referred to the genetics team initially; this increased to 70% in the second audit. While almost half (46%) of the women with MR or HR had inappropriate FUI in the initial audit, this fell to 11% in the re‐audit. Conclusions A proportion of women diagnosed with BC would fall into the MR or HR categories as defined in the NICE FH guidance. Inadequate recording of FH could result in inadequate FUI surveillance and in some cases missing the opportunity for a genetic referral to assess suitability for gene testing.
All-optical PtSe2 silicon photonic modulator with ultra-high stability
Authors: Wei Kangkang , Li Delong , Lin Zhitao , Cheng Zhao , Yao Yuhan , Guo Jia , Wang Yunzheng , Zhang Yupeng , Dong Jianji , Zhang Han , Zhang Xinliang 
Published: May 2020

All-optical modulation based on the photothermal effect of two-dimensional (2D) materials shows great promise for all-optical signal processing and communication. In this work, an all-optical modulator with a 2D

PtSe

2

-on-silicon structure based on a microring resonator is proposed and demonstrated utilizing the photothermal effect of

PtSe

2

. A tuning efficiency of

0.0040

nm

·

mW

−
1

is achieved, and the 10%–90% rise and decay times are 304 μs and 284 μs, respectively. The fabricated device exhibits a long-term air stability of more than 3 months. The experimental results prove that 2D

PtSe

2

has great potential for optical modulation on a silicon photonic platform.
Low-loss hybrid plasmonic TM-pass polarizer using polarization-dependent mode conversion
Authors: Chen Ruixuan , Bai Bowen , Zhou Zhiping 
Published: May 2020

A low-loss hybrid plasmonic transverse magnetic (TM)-pass polarizer has been demonstrated utilizing polarization-dependent mode conversion. Taking advantage of the silicon hybrid plasmonic slot waveguide (HPSW), the unwanted transverse electric (TE) fundamental mode can be efficiently converted first to a TM higher-order mode and then suppressed by a power combiner, while the retained TM fundamental mode can pass through with negligible influence. Since the HPSW feature both strong structural asymmetry and a small interaction area in the cross-section between the metal and optical field, the optimized insertion loss of the device is as low as 0.4 dB. At the wavelength of 1550 nm, the extinction ratio is 28.3 dB with a moderate footprint of

2.38

μm
×
10

μm

. For the entire C band, the average reflection of the TE mode is suppressed below

−
14

dB

, and the extinction ratio is over 18.6 dB. This work provides another more efficient and effective approach for better on-chip polarizers.
Linkage Disequilibrium-Based Inference of Genome Homology and Chromosomal Rearrangements Between Species
Authors: de Abreu Santos Daniel Jordan , Ferreira de Camargo Gregório Miguel , Cardoso Diercles Francisco , Buzanskas Marcos Eli , Aspilcueta-Borquis Rusbel Raul , Hurtado-Lugo Naudin Alejandro , de Araújo Neto Francisco Ribeiro , Galvão de Albuquerque Lúcia , Ma Li , Tonhati Humberto 
Published: May 2020

AbstractThe aim of this study was to analyze the genomic homology between cattle (Bos taurus) and buffaloes (Bubalus bubalis) and to propose a rearrangement of the buffalo genome through linkage disequilibrium analyses of buffalo SNP markers referenced in the cattle genome assembly and also compare it to the buffalo genome assembly. A panel of bovine SNPs (single nucleotide polymorphisms) was used for hierarchical, non-hierarchical and admixture cluster analyses. Thus, the linkage disequilibrium information between markers of a specific panel of buffalo was used to infer chromosomal rearrangement. Haplotype diversity and imputation accuracy of the submetacentric chromosomes were also analyzed. The genomic homology between the species enabled us to use the bovine genome assembly to recreate a buffalo genomic reference by rearranging the submetacentric chromosomes. The centromere of the submetacentric chromosomes exhibited high linkage disequilibrium and low haplotype diversity. It allowed hypothesizing about chromosome evolution. It indicated that buffalo submetacentric chromosomes are a centric fusion of ancestral acrocentric chromosomes. The chronology of fusions was also suggested. Moreover, a linear regression between buffalo and cattle rearranged assembly and the imputation accuracy indicated that the rearrangement of the chromosomes was adequate. When using the bovine reference genome assembly, the rearrangement of the buffalo submetacentric chromosomes could be done by SNP BTA (chromosome of Bos taurus) calculations: shorter BTA (shorter arm of buffalo chromosome) was given as [(shorter BTA length – SNP position in shorter BTA)] and larger BTA length as [shorter BTA length + (larger BTA length – SNP position in larger BTA)]. Finally, the proposed linkage disequilibrium-based method can be applied to elucidate other chromosomal rearrangement events in other species with the possibility of better understanding the evolutionary relationship between their genomes.
Polymorphism of vascular endothelial growth factor gene (<i>VEGF</i>) and matrix metalloproteinase (<i>ММР</i>) genes in primary limb lymphedema
Authors: Shevchenko A. V. , Prokofyev V. F. , Konenkov V. I. , Khapaev R. S. , Nimaev V. V. 
Published: May 2020

Among the reasons of primary lymphedema development, a certain role belongs to genetic factors. The specific molecular products participate in remodeling of blood and lymphatic vascular networks. Vascular endothelial growth factors (VEGFs) are key regulators of endothelial functions of the cells, which are responsible for lympho- and vasculogenesis. Moreover, matrix metalloproteinases (ММР) may act as regulators of both lymphangiogenesis, and angiogenesis. Since the regulatory regions of VEGFA gene, as well as of ММР genes are polymorphic, one may suggest, that their different expression level, determined by these polymorphisms, could be associated with development of swellings typical for lymphedema.We have analyzed gene polymorphisms in two regulatory regions of vascular endothelial growth factor-A VEGF-A (rs 699947 and rs 3025039), and matrix metalloproteinase genes MMP2 (rs 2438650), MMP3 (rs 3025058), MMP9 (rs 3918242), and their combinations in the patients with primary lymphedema.A group of patients with primary lymphedema included 72 subjects (55 women and 17 men) at the age of 18 to 81 years. Control group included 526 inhabitants of Novosibirsk (153 men, 373 women) without chronic diseases, comparable for age with lymphedema patients. We have performed typing of regulatory regions in VEGF (rs 699947, rs 3025039), ММР2 (rs 2438650), ММР3 (rs 3025058), ММР9 genes (rs 3918242). Fifteen complex genotypes have been revealed that were positively associated with disease. Analysis of the gene network topology has outlined the main intergenic interactions upon primary lymphedema development. MMP2 -1306 CC, MMP9 -1562CC and VEGF +936CC arrange the basic knots in the gene network (53% of total interactions). A number of significantly different complex genotypes was revealed at patients with primary lymphedema with normal body mass index (BMI < 25) and obesity (BMI < 30). Hence, frequency of complex genotype VEGF +936 CC: MMP3 -1171 5А6А:MMP9 -1562 CC in the patients with obesity is increased more 5.5-fold compared to the patients with normal BMI.The data obtained may presume a certain value of the analyzed gene polymorphisms in pathogenesis of primary lymphedema. Topological analysis of gene networks allows to study the structural and functional organization of gene-gene interactions for development of approaches to individyal preventive maintenance and therapy of the disease.
¿Epistemología bíblica para la investigación adventista? Una propuesta de trabajo - Biblical Epistemology for Adventist Scholarship? A Working proposal
Authors: Canale Fernando 
Published: May 2020

Desde la creación de las primeras universidades adventistas a inicios de la segunda mitad del siglo veinte, la Iglesia Adventista del Séptimo Día ha participado en la investigación científica en varias disciplinas académicas seculares y teológicas que involucran el uso de metodología y razón humana. Debido a que normalmente, los investigadores seleccionan y usan metodologías basándose en el actual consenso de sus disciplinas académicas, y asumimos que eruditos adventistas hacen lo mismo. Rara vez los científicos se dan tiempo de analizar, evaluar y criticar las herramientas intelectuales que usan. Este estudio aborda la necesidad de implementar una epistemología bíblica para desarrollar investigaciones con perfil adventista.
Pendeteksian Harmonisa Arus Berbasis Feed Forward Neural Network Secara Real Time
Authors: Wahjono Endro , Anggriawan Dimas Okky , Satriawan Achmad Luki , Firdaus Aji Akbar , Prasetyono Eka , Sudiharto Indhana , Tjahjono Anang , Budikarso Anang 
Published: May 2020

The development of power electronics converters has been widespread in the industrial, commercial, and home applications. The device is considered to produce harmonics in non-linear loads. Harmonics cause a decrease in power quality in the electric power system. To prevent a decrease in power quality caused by harmonics in the power system, the detection of harmonics has an important role. Therefore, this paper proposed feed forward neural network (FFNN) for harmonic detection. The design of harmonic detection device is designed with a feed forward neural network method that it has two stages of information processing, namely the training stage and the testing stage. FFNN has input harmonics and THDi as output. To detect harmonics, frst training is conducted to recognize waveform patterns and calculate the fast fourier transform (FFT) process ofﬂine. Prototype using the AMC1100DUB current sensor, microcontroller and display. To validate the proposed algorithm, compared by standard measurement tool and FFT. The results show the proposed algorithm has good performance with the average percentage error compared by standard measurement tool and FFT of 5.33 %.
Hardware Simulation of Rear-End Collision Avoidance System Based on Fuzzy Logic
Authors: Basjaruddin Noor Cholis , Saefudin Didin , Pancawati Anggun 
Published: May 2020

Rear-end collisions are the most common type of traffc accident. On the highway, a real-end collision may involve more than two vehicles and cause a pile-up or chain-reaction crash. Referring to data released by the Australian Capital Territory (ACT), rear-end collisions which occurred throughout 2010 constituted as much as 43.65% of all collisions. In most cases, these rear-end collisions are caused by inattentive drivers, adverse road conditions and poor following distance. The Rear-end Collision Avoidance System (RCAS) is a device to help drivers to avoid rear-end collisions. The RCAS is a subsystem of Advanced Driver Assistance Systems (ADASs) and became an important part of the driverless car. This paper discusses a hardware simulation of a RCAS based on fuzzy logic using a remote control car. The Mamdani method was used as a fuzzy inference system and realized by using the Arduiono Uno microcontroller system. Simulation results showed that the fuzzy logic algorithm of RCAS can work as designed.