bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unexpected mould diversity in clinical isolates from French Guiana and associated identification difficulties
Authors: Nabet C , Imbert S , Normand A C , Blanchet D , Chanlin R , Becker P , Demar M , Piarroux R 
Published: October 2020

AbstractNew mold species are increasingly reported in invasive fungal infections. However, these fungi are often misdiagnosed or undiagnosed due to the use of inappropriate laboratory diagnostic tools. Tropical countries, such as French Guiana, harbor a vast diversity of environmental fungi representing a potential source of emerging pathogens. To assess the impact of this diversity on the accuracy of mold-infection diagnoses, we identified mold clinical isolates in French Guiana during a five-month follow-up using both microscopy and matrix-assisted laser desorption ionization time-of-flight mass spectrometry. In total, 38.8% of the 98 obtained molds isolates could not be identified and required a DNA-based identification. Fungal diversity was high, including 46 species, 26 genera, and 13 orders. Fungal ecology was unusual, as Aspergillus species accounted for only 27% of all isolates, and the Nigri section was the most abundant out of the six detected Aspergillus sections. Macromycetes (orders Agaricales, Polyporales, and Russulales) and endophytic fungi accounted for respectively 11% and 14% of all isolates. Thus, in tropical areas with high fungal diversity, such as French Guiana, routine mold identification tools are inadequate. Molecular identifications, as well as morphological descriptions, are necessary for the construction of region-specific mass spectrum databases. These advances will improve the diagnosis and clinical management of new fungal infections.
Properties of flares and CMEs on EV Lac: possible erupting filament
Authors: Muheki Priscilla , Guenther E W , Mutabazi T , Jurua E 
Published: October 2020

ABSTRACTFlares and coronal mass ejections (CMEs) are very powerful events in which energetic radiation and particles are ejected within a short time. These events thus can strongly affect planets that orbit these stars. This is particularly relevant for planets of M-stars, because these stars stay active for a long time during their evolution and yet potentially habitable planets orbit at short distance. Unfortunately, not much is known about the relation between flares and CMEs in M-stars as only very few CMEs have so far been observed in M-stars. In order to learn more about flares and CMEs on M-stars, we monitored the active M-star EV Lac spectroscopically at high resolution. We find 27 flares with energies between 1.6 × 1031 and 1.4 × 1032 erg in $\rm H\alpha$ during 127 h of spectroscopic monitoring and 49 flares with energies between 6.3 × 1031 and 1.1 × 1033 erg during the 457 h of Transiting Exoplanet Survey Satellite (TESS) observation. Statistical analysis shows that the ratio of the continuum flux in the TESS band to the energy emitted in $\rm H\alpha$ is 10.408 ± 0.026. Analysis of the spectra shows an increase in the flux of the He ii 4686 Å line during the impulsive phase of some flares. In three large flares, we detect a continuum source with a temperature between 6900 and 23 000 K. In none of the flares we find a clear CME event indicating that these must be very rare in active M-stars. However, in one relatively weak event, we found an asymmetry in the Balmer lines of ${\sim}220\, \rm km\, s^{-1}$, which we interpret as a signature of an erupting filament.
The impact of disturbed galaxy clusters on the kinematics of active galactic nuclei
Authors: Bilton Lawrence E , Pimbblet Kevin A , Gordon Yjan A 
Published: October 2020

ABSTRACT
We produce a kinematic analysis of AGN-hosting cluster galaxies from a sample of 33 galaxy clusters selected using the X-ray Clusters Database (BAX) and populated with galaxies from the Sloan Digital Sky Survey Data Release 8. The 33 galaxy clusters are delimited by their relative intensity of member galaxy substructuring as a proxy to core merging to derive two smaller sub-samples of 8 dynamically active (merging) and 25 dynamically relaxed (non-merging) states. The AGN were selected for each cluster sub-sample by employing the WHAN diagram to the strict criteria of log10([N ii]/Hα) ≥ −0.32 and EWHα ≥ 6 Å, providing pools of 70 mergings and 225 non-merging AGN sub-populations. By co-adding the clusters to their respective dynamical states to improve the signal-to-noise ratio of our AGN sub-populations we find that merging galaxy clusters on average host kinematically active AGN between 0–1.5r200 as r200 → 0, where their velocity dispersion profile (VDP) presents a significant deviation from the non-AGN sub-population VDP by ≳3σ. This result is indicative that the AGN-hosting cluster galaxies have recently coalesced on to a common potential. Further analysis of the composite distributions illustrates non-merging AGN-hosting sub-populations have, on average, already been accreted and predominantly lie within backsplash regions of the projected phase-space. This suggests merging cluster dynamical states hold relatively younger AGN sub-populations kinematically compared with those found in non-merging cluster dynamical states.
Missing [C ii] emission from early galaxies
Authors: Carniani S , Ferrara A , Maiolino R , Castellano M , Gallerani S , Fontana A , Kohandel M , Lupi A , Pallottini A , Pentericci L , Vallini L , Vanzella E 
Published: October 2020

ABSTRACT
ALMA observations have revealed that [C ii] 158 μm line emission in high-z galaxies is ≈2–3 × more extended than the UV continuum emission. Here we explore whether surface brightness dimming (SBD) of the [C ii] line is responsible for the reported [C ii] deficit, and the large $L_{\rm [O\, \small {III}]}/L_{\rm [C\, \small {II}]}$ luminosity ratio measured in early galaxies. We first analyse archival ALMA images of nine z &gt; 6 galaxies observed in both [C ii] and [O iii]. After performing several uv-tapering experiments to optimize the identification of extended line emission, we detect [C ii] emission in the whole sample, with an extent systematically larger than the [O iii] emission. Next, we use interferometric simulations to study the effect of SBD on the line luminosity estimate. About 40 per cent of the extended [C ii] component might be missed at an angular resolution of 0.8 arcsec, implying that $L_{\rm [C\, \small {II}]}$ is underestimated by a factor ≈2 in data at low (&lt;7) signal-to-noise ratio. By combining these results, we conclude that $L_{\rm [C\, \small {II}]}$ of z &gt; 6 galaxies lies, on average, slightly below the local $L_{\rm [C\, \small {II}]}-\mathrm{ SFR}$ relation (Δz = 6–9 = −0.07 ± 0.3), but within the intrinsic dispersion of the relation. SBD correction also yields $L_{\rm [O\, \small {III}]}/L_{\rm [C\, \small {II}]}\lt 10$, i.e. more in line with current hydrodynamical simulations.
The Mode of Action of Endosidin20 Differs from That of Other Cellulose Biosynthesis Inhibitors
Authors: Huang Lei , Zhang Chunhua 
Published: October 2020

Abstract
Endosidin20 (ES20) was recently identified as a cellulose biosynthesis inhibitor (CBI) that targets the catalytic domain of CELLULOSE SYNTHASE 6 (CESA6) and thus inhibits the growth of Arabidopsis thaliana. Here, we characterized the effects of ES20 on the growth of other plant species and found that ES20 is a broad-spectrum plant growth inhibitor. We tested the inhibitory effects of previously characterized CBIs (isoxaben, indaziflam and C17) on the growth of Arabidopsis cesa6 mutants that have reduced sensitivity to ES20. We found that most of these mutants are sensitive to isoxaben, indaziflam and C17, indicating that these tested CBIs have a different mode of action than ES20. ES20 also has a synergistic inhibitory effect on plant growth when jointly applied with other CBIs, further confirming that ES20 has a different mode of action than isoxaben, indaziflam and C17. We demonstrated that plants carrying two missense mutations conferring resistance to ES20 and isoxaben can tolerate the dual inhibitory effects of these CBIs when combined. ES20 inhibits Arabidopsis growth in growth medium and in soil following direct spraying. Therefore, our results pave the way for using ES20 as a broad-spectrum herbicide, and for the use of gene-editing technologies to produce ES20-resistant crop plants.
Mineralogical Constraints on the Magma Mixing Beneath the Iheya Graben, an Active Back-Arc Spreading Centre of the Okinawa Trough
Authors: Zhang Yu-Xiang , Zeng Zhi-Gang , Gaetani Glenn , Zhang Le , Lai Zhi-Qing 
Published: October 2020

Abstract
The Iheya Graben is a back-arc spreading centre in the middle part of the Okinawa Trough. It is also located in the centre of an anomalous volcanic zone (volcanic arc migration phenomenon, or VAMP) and is characterized by bimodal volcanism, unusually high heat flow and active hydrothermal circulation. The subvolcanic magma plumbing system and the magmatic processes related to the formation of rare erupted intermediate lavas in this area remain uncertain. In this study, we conducted systematic mineralogical analyses (in situ major element, trace element and Sr isotopes) and whole rock geochemical analyses (major element, trace element and Sr–Nd isotopes) on an andesite (T5-2; type C andesite) and a rhyolite (C11; type 2 rhyolite), and present evidence for magma mixing in the origins of these lavas. Andesite T5-2 contains a mafic mineral assemblage and a silicic mineral assemblage, which are derived from a basaltic melt and a type 2 rhyolitic melt, respectively. A 4:6 mixture of basalt and type 2 rhyolite from the Iheya Graben reproduces the whole-rock major element, trace element, and Sr–Nd isotope compositions of T5-2. Rhyolite C11 contains a group of disequilibrium minerals that crystallized from a less evolved rhyolitic melt with relatively more enriched Sr–Nd isotope compositions, suggesting mixing of this melt with a more evolved and isotopically more depleted rhyolitic melt. This mixing process could produce a series of rhyolitic melts with a negative correlation between SiO2 concentrations and 87Sr/86Sr ratios (or a positive correlation for 143Nd/144Nd ratios), which are recorded by the whole group of type 2 rhyolites. The results from mineral-based thermobarometers suggest that the premixing storage temperatures of the basaltic and rhyolitic melts are ∼1100 °C and 870–900 °C, respectively. The hybrid andesitic melt has temperatures of ∼950 to ∼980 °C. The magma storage pressures are not well constrained, ranging from ∼400 MPa to ∼100 MPa. We show that magma mixing plays a significant role in the origins of diverse volcanism in the middle Okinawa Trough; more specifically, two of the three types of andesites (types B and C) and one of the two types of rhyolites (type 2) are associated with magma mixing. We thus propose a complex magma plumbing system with multichamber magma storage and frequent magma mixing beneath the Iheya Graben.
Academic entrepreneurship and attentional discrepancy among key stakeholders: Evidence from research universities in Korea
Authors: Kang Dong-In , Kang In-Je , Kim Yeong-Ju , Nguyen Chi Mai , Choung Jae-Yong 
Published: October 2020

Abstract
While understandings on the institutional environment and individual motivations have been at the center of describing the antecedents of academic entrepreneurship, findings from this research trigger skepticism in the currently dominant perspective. By building on the traditional institutional theory with insights from the stakeholders and attention-based perspectives, it is possible to postulate that reaching multiple stakeholders’ needs is essential in maximizing the effectiveness of a collective entrepreneurial process. We argue that aligning selective interests, or attentions, among key stakeholders is a critical factor that promotes academic entrepreneurship. Quantitative and qualitative investigations on Korean research universities confirm that involved stakeholders are subject to severe discrepancy in how they place attentional prioritizations in technology, formal institution, and informal institution capabilities. In spite of favorable national and university incentives, the different degrees of misaligned interests among key players prove to hold heavy repercussions in the collective planning and execution of academic entrepreneurship.
Early Life Exposure to Environmental Contaminants (BDE-47, TBBPA, and BPS) Produced Persistent Alterations in Fecal Microbiome in Adult Male Mice
Authors: Gomez Matthew V , Dutta Moumita , Suvorov Alexander , Shi Xiaojian , Gu Haiwei , Mani Sridhar , Yue Cui Julia 
Published: October 2020

Abstract
The gut microbiome is a pivotal player in toxicological responses. We investigated the effects of maternal exposure to 3 human health-relevant toxicants (BDE-47, tetrabromobisphenol [TBBPA], and bisphenol S [BPS]) on the composition and metabolite levels (bile acids [BAs] and short-chain fatty acids [SCFAs]) of the gut microbiome in adult pups. CD-1 mouse dams were orally exposed to vehicle (corn oil, 10 ml/kg), BDE-47 (0.2 mg/kg), TBBPA (0.2 mg/kg), or BPS (0.2 mg/kg) once daily from gestational day 8 to the end of lactation (postnatal day 21). 16S rRNA sequencing and targeted metabolomics were performed in feces of 20-week-old adult male pups (n = 14 − 23/group). Host gene expression and BA levels were quantified in liver. BPS had the most prominent effect on the beta-diversity of the fecal microbiome compared with TBPPA and BDE-47 (QIIME). Seventy-three taxa were persistently altered by at least 1 chemical, and 12 taxa were commonly regulated by all chemicals (most of which were from the Clostridia class and were decreased). The most distinct microbial biomarkers were S24-7 for BDE-47, Rikenellaceae for TBBPA, and Lactobacillus for BPS (LefSe). The community-wide contributions to the shift in microbial pathways were predicted using FishTaco. Consistent with FishTaco predictions, BDE-47 persistently increased fecal and hepatic BAs within the 12α hydroxylation pathway, corresponding to an up-regulation with the hepatic BA-synthetic enzyme Cyp7a1. Fecal BAs were also persistently up-regulated by TBBPA and BPS (liquid chromatography-mass spectrometry). TBBPA increased propionic acid and succinate, whereas BPS decreased acetic acid (gas chromatography-mass spectrometry). There was a general trend in the hepatic down-regulation of proinflammatory cytokines and the oxidative stress sensor target gene (Nqo1), and a decrease in G6Pdx (the deficiency of which leads to dyslipidemia). In conclusion, maternal exposure to these toxicants persistently modified the gut-liver axis, which may produce an immune-suppressive and dyslipidemia-prone signature later in life.
Comprehensive In Silico Evaluation of Accessory Rod Position, Rod Material and Diameter, Use of Cross-connectors, and Anterior Column Support in a Pedicle Subtraction Osteotomy Model
Authors: Jazini Ehsan , Gelb Daniel E. , Tareen Jarid , Ludwig Steven C. , Harris Jonathan A. , Amin Dhara B. , Wang Wenhai , Van Horn Margaret R. , Patel Pavan D. , Mirabile Belin A. , Bucklen Brandon S. 
Published: October 2020

Study Design.

In silico finite element study.

Objective.
The aim of this study was to evaluate effects of six construct factors on rod and screw strain at the lumbosacral junction in an in silico pedicle subtraction osteotomy (PSO) model: traditional inline and alternative Ames-Deviren-Gupta (ADG) multi-rod techniques, number of accessory rods (three-rod vs. four-rod), rod material (cobalt-chrome [CoCr] or stainless steel [SS] vs. titanium [Ti]), rod diameter (5.5 vs. 6.35 mm), and use of cross-connectors (CC), or anterior column support (ACS).

Summary of Background Data.
Implant failure and pseudoarthrosis at the lumbosacral junction following PSO are frequently reported. Clinicians may modulate reconstructs with multiple rods, rod position, rod material, and diameter, and with CC or ACS to reduce mechanical demand. An evaluation of these features’ effects on rod and screw strains is lacking.

Methods.
A finite element model (T12–S1) with intervertebral discs and ligaments was created and validated with cadaveric motion data. Lumbosacral rod and screw strain data were collected for 96 constructs across all six construct factors and normalized to the Ti 2-Rod control.

Results.
The inline technique resulted in 12.5% to 51.3% more rod strain and decreased screw strain (88.3% to 95%) compared to ADG at the lumbosacral junction. An asymmetrical strain distribution was observed in the three-rod inline technique in comparison to four-rod, which was more evenly distributed. Regardless of construct features, rod strain was significantly decreased by rod material (CoCr > SS > Ti), and increasing rod diameter from 5.5 mm to 6.35 mm reduced strain by 9.9% to 22.1%. ACS resulted in significant reduction of rod (37.8%–59.8%) and screw strains (23.2%–65.8%).

Conclusion.
Increasing rod diameter, using CoCr rods, and ACS were the most effective methods in reducing rod strain at the lumbosacral junction. The inline technique decreased screw strain and increased rod strain compared to ADG.

Level of Evidence: N/A.
Hangman’s Fracture
Authors: Turtle Joel , Kantor Adam , Spina Nicholas T. , France John C. , Lawrence Brandon D. 
Published: October 2020

Study Design:
Review article.

Objective:
A review and update of the treatment of Hangman’s fractures including the indications for both nonoperative and operative treatment of typical and atypical fractures.

Summary of Background Data:
Hangman’s fractures are the second most common fracture pattern of the C2 vertebrae following odontoid fractures. Many of the stable extension type I and II fractures can be treated with external immobilization, whereas the predominant flexion type IIa and III fractures require surgical stabilization.

Methods:
A review of the literature.

Results:
The clinical and radiographic outcomes of the treatment of Hangman’s fractures lend a good overall prognosis when the correct diagnosis is made. The nonoperative treatment of stable type I and II fractures with external immobilization leads to excellent long-term outcomes as does the operative treatment of the unstable type IIa and III fractures.

Conclusions:
Hangman’s fractures can be classified as stable (type I and most II) or unstable (type IIa and III) and the optimal treatment depends upon this distinction. Stable injuries do well with rigid immobilization and rarely require operative intervention. In contrast, unstable injuries do poorly if treated nonoperatively but do well with surgical intervention. When treating atypical Hangman’s variants, great vigilance and close clinical observation is paramount if nonoperative treatment is indicated given the potential for neurological compression in this fracture pattern. Properly identifying and treating these injuries represents an opportunity for the spine surgeon to optimize patient outcomes.
Association between polymorphisms in the vitamin D receptor and susceptibility to multiple sclerosis
Authors: Cancela Díez Bárbara , Pérez-Ramírez Cristina , Maldonado-Montoro María del Mar , Carrasco-Campos María Isabel , Sánchez Martín Almudena , Pineda Lancheros Laura Elena , Martínez-Martínez Fernando , Calleja-Hernández Miguel Ángel , Ramírez-Tortosa María Carmen , Jiménez-Morales Alberto 
Published: October 2020

Objectives
Multiple sclerosis (MS) is a neurodegenerative chronic inflammatory. Mutations in the vitamin D receptor (VDR) gene can substantially affect serum vitamin D levels or alter its functionality, and can consequently increase susceptibility to developing MS. The objective of this study was to evaluate the association between polymorphisms in the VDR gene and risk of MS in a (Spanish) Caucasian population.

Patients and methods
We conducted a retrospective case-control study comprising 209 patients with relapsing-remitting multiple sclerosis (RRMS) and 836 controls of Caucasian origin from southern Spain. The ApaI (rs7975232), BsmI (rs1544410), Cdx2 (rs11568820), FokI (rs2228570), and TaqI (rs731236) gene polymorphisms were determined by allelic discrimination real-time PCR using TaqMan probes.

Results
The recessive logical regression model, adjusted for age and sex, revealed that the TT genotype for VDR FokI (rs2228570) polymorphism was associated with higher risk of MS (P = 0.0150; OR = 1.82; 95% CI = 1.12–2.94; TT vs. CT + CC). No association between the other polymorphisms and development of MS was found in any of the models analyzed. The haplotype analysis, adjusted for age, smoking, and sex, did not find any statistically significant association between the haplotypes analyzed and risk of MS.

Conclusions
The VDR FokI (rs2228570) polymorphism was significantly associated with developing MS. We found no influence of the ApaI (rs7975232), BsmI (rs1544410), Cdx2 (rs11568820), FokI (rs2228570), and TaqI (rs731236) gene polymorphisms on the risk of developing MS in our patients.
Age-Related Changes in Astigmatism and Potential Causes
Authors: Namba Hiroyuki , Sugano Akira , Murakami Takanori , Utsunomiya Hiroshi , Nishitsuka Koichi , Ishizawa Kenichi , Kayama Takamasa , Yamashita Hidetoshi 
Published: October 2020

Abstract:
Astigmatism causes deterioration of the retinal image and affects vision quality. Maintenance and improvement of visual function requires an understanding of the prevalence, age-related changes, and mechanisms of astigmatism. In this article, we discuss the findings of studies that investigated astigmatism. Some of these studies showed that the prevalence of high degrees of astigmatism in childhood typically decreases with emmetropization. With-the-rule astigmatism occurs most commonly in young adults. With age, the prevalence of astigmatism increases, and the axis shifts from a predominance of with-the-rule astigmatism to a predominance of against-the-rule astigmatism. This age-related change is caused by alterations in corneal curvature. Although the cause of this change is not fully understood, alterations in the position and tension of the eyelid, corneal stromal collagen fibrils, Descemet membrane, and extraocular muscles may influence the shape of the cornea. Furthermore, genetic factors may contribute to the development of astigmatism. Technological advances in ophthalmology are expected to improve our understanding of the etiology of astigmatism and enable the maintenance of quality of vision.