bluuebunny/crossref_metadata_2025_split huggingface dataset:
A preliminary qualitative study of general practitioners’ views on malnutrition management and oral nutritional supplementation prescription in the community
Authors: Castro Patricia Domínguez , Kennelly Sharon , Clyne Barbara , Bury Gerard , Bradley Catriona , Finnigan Karen , McCullagh Laura , Barry Michael , Murrin Celine , Perrotta Carla , Villaroel Katherine Loayza , Reynolds Ciara , Gibney Eileen , Corish Clare 
Published: June 2020

AbstractMalnutrition, arising from a deficiency of energy and protein intake, occurs commonly among community-dwelling individuals. Oral nutritional supplements (ONS) are an effective method of managing malnutrition if prescribed for patients who are malnourished or at risk of malnutrition. However, previous research indicates that inappropriate prescribing of ONS occurs frequently in the community setting (30–70% prevalence). Moreover, it has been previously shown that the management of patients ‘at risk’ of malnutrition in the primary care/community setting in Ireland is sub-optimal, with low awareness of the condition and its management among non-dietetic health care professionals (HCPs). In Ireland, general practitioners (GPs) are the main prescribers of ONS in primary care. They are also on many occasions the first point of contact for individuals in the community who are malnourished or at risk of malnutrition. Therefore, exploring their experiences and perceptions can provide insight into the complexities of managing malnutrition and ONS prescribing in the community. The aim of this qualitative study was to explore GPs’ experiences and opinions on the management of malnutrition and the prescription of ONS in the primary care/community setting in Ireland. Semi-structured interviews were conducted with nine GPs. The interview explored among others the following domains; Barriers and facilitators in the management of malnutrition, ONS prescribing in the primary care/community setting, and future directions in the management of malnutrition and ONS prescribing. Recorded interviews were transcribed and analysed using inductive thematic analysis. Three main themes were identified; i) Malnutrition a secondary concern, encapsulating the idea that malnutrition is not something that GPs screen for in isolation ii) Resources and support for managing malnutrition are needed in the community iii) Reluctance to prescribe ONS. GPs reported not screening for malnutrition, but viewed it as a consequence of other conditions and social factors. According to the GPs, they should not have sole responsibility for malnutrition management and more dietitians and trained community nurses would be desirable to support them to deal with malnutrition in the community. A preference to avoid supplementation and implement dietary changes first was expressed by GPs. As main prescribers, GPs thought that they should receive further independent trainingon the different ONS available in the market as currently they did not feel confident prescribing a range of them. Awareness of ONS cost and its misuse by certain patients were reported as reasons that made GPs reluctant to prescribe them, potentially leading to under prescribing.
Legume consumption in Sweden: a descriptive cross-sectional study
Authors: Céline Steib , Johansson Ingegerd , Hefni Mohammed , Witthöft Cornelia 
Published: June 2020

AbstractDespite the growing evidence supporting legume consumption as part of healthy and sustainable diet, little information is known on legume intake in the Swedish population. The aim of the present study was to describe legume consumers in Sweden, their nutrient intake and study the association with biomarkers of nutritional status using food consumption and biomonitoring data from Swedish adults in the 2010–11 National Riksmaten survey. Total legume intake - including pulses, fresh legumes, soy products, peanuts, sprouts and mixed meals with legumes - was estimated using a web-based 4-d food records in adults 18–80 years (n = 1772). A range of biomarkers including non-fasted plasma ferritin and folate, as well as erythrocyte folate, were measured for a subsample of the population (n = 282). Legumes were consumed by 44% of the population, median intake was 36 g/d (Q1 = 16; Q3 = 71; n = 777). Legumes provided on average 3.3% of individual's total energy intake (%E) with no significant difference between sexes. Pulses were consumed by 33% of consumers contributing to 3.2 ± 2.8 %E intake whereas soy products were consumed by 8.6% of legume consumers but contributing to 6 ± 7.5 %E. Legume intake among self-reported vegetarians (n = 55) was significantly higher (p < 0.000) than for non-vegetarians, with mean daily intakes of 92 ± 99 g/d and 21 ± 42 g/d, respectively. Age (p 0.0066) was significantly higher in Q4 of legume intake and alcohol consumption was significantly lower (p 0.0008); BMI, gender, smoking habits, education and total energy intake did not differ. 23% of legume consumers have a fiber intake of 25–35 g/d whereas only 11% of non-consumers reach recommended intake (p 0.0001). Iron, folate and dietary fiber intakes were significantly higher (p < 0.000) in Q4 of legume intake. 32% of legume consumers meet recommended intakes of folate (RI 300 μg/d) versus 18% for non-consumers (p 0.000). Notably, 5.76% of women of reproductive age (18–44 y.o.) eating legumes reach 400 μg/d versus 0.79% for non-consumers (p 0.002). Plasma ferritin and erythrocyte folate levels did not differ between legume consumers and non-consumers. However, for women in reproductive age (n = 31), plasma folate levels were significantly higher in consumers than non-consumers (p 0.0102). Legume consumers have higher fiber intake and more frequently meet recommended folate intakes while maintaining adequate iron intake. In conclusion, legume consumers in Sweden are characterized by a defined diet pattern that generally is associated with better health.
Higher adherence to the Mediterranean Diet is associated with weight loss maintenance: the MedWeight study
Authors: Poulimeneas Dimitrios , Zoupi Katerina , Mamalaki Eirini , Bathrellou Eirini , Anastasiou Costas , Panagiotakos Demosthenes , Yannakoulia Mary 
Published: June 2020

AbstractIntroductionAdherence to the Mediterranean dietary pattern has been associated with numerous health benefits in non-communicable diseases, including obesity management. However, the associations of the Mediterranean Diet with weight loss maintenance remain to be evaluated.MethodsWe analyzed data from 500 participants (61% women) of the MedWeight study. Eligible volunteers were men and women 18–65 years old, reporting an intentional weight loss of at least 10%, starting from a BMI ≥ 25 kg/m2. Based on their current weight, participants were characterized as maintainers (current weight ≤ 90% of maximum weight), or regainers (current weight > 95% of maximum weight). Socio-demographics, lifestyle measurements and weight history were recorded. Dietary intake was assessed by 2 telephone 24-hour recalls. Adherence to the Mediterranean Diet was assessed with the MedDietScore (range 0–55, greater scores showing higher adherence). Physical activity levels were assessed with the International Physical Activity Questionnaire-short form. Results are expressed as means ± SD, frequencies (%) or Odds Ratio [OR; 95%Confidence Interval].ResultsCompared to regainers (31%), maintainers were younger (31.4 ± 10.0 vs. 36.6 ± 10.8 years, p < 0.001), had lower BMI (25.7 ± 4.3 vs. 31.4 ± 5.1 kg/m2, p < 0.001), and had greater initial body weight loss (25.5 ± 8.6% vs. 18.4 ± 6.9%, p < 0.001). Sex and years of formal education were not significantly different between maintainers and regainers (p > 0.05). Being in the highest MedDietScore quintile (vs. the lowest) was associated with 91% higher odds of being a maintainer [crude OR = 1.91; 1.05–3.45]. This association remained significant after adjusting for sex, age, physical activity level (METŸminutes/week) and energy intake (kcal/day) [adjusted OR = 2.01; 1.05–3.83].DiscussionHigher adherence to the Mediterranean Diet was independently associated with 2-fold increased likelihood of weight loss maintenance. Our results highlight the favorable effects of a prudent dietary pattern in long-term obesity management, as well as novel targets for diet planning during weight loss maintenance.
Is frequency of sugary food consumption associated with body mass index?
Authors: Lommi Sohvi , Figueiredo Rejane , Tuorila Hely , Viljakainen Heli 
Published: June 2020

AbstractRelatively convincing evidence suggests that diets with large amounts of added sugar, especially from sugar-sweetened beverages, are associated with excess weight in children. Less is known about the association of consumption frequency of sugary foods with body mass index (BMI). We evaluated frequency of sugary food consumption in children (n = 8,990, mean age 11.1, ± 0.9) from the Finnish Health in Teens (Fin-HIT) cohort study. They answered a questionnaire including a 16-item food frequency questionnaire (FFQ) and lifestyle-related questions, e.g. sleep duration and leisure time physical activity. Their measured BMI was categorized as underweight, normal-weight, and overweight. Based on the FFQ with six sugary food items (chocolate/sweets, biscuits/cookies, ice cream, sweet pastry, sugary juice drinks and sugary soft drinks), a sugary food index (SFI) was derived to indicate a mean frequency of weekly sugary food consumption. Frequency was estimated with a range of 0–14 times a week. Based on quartiles (Q) of SFI, children were categorized as low (Q1, cut-off < 0.7), medium (Q2 + Q3, cut-off 0.7–1.8), and high (Q4, cut-off > 1.8) consumers. Multinomial logistic regression analysis was conducted to obtain odds ratios (OR) with 95% confidence intervals. Compared with normal-weight children, high consumers had a higher risk for underweight (OR 1.22 [1.04; 1.43]) and a lower risk for overweight (OR 0.86 [0.72; 0.97]), and low consumers had a higher risk for overweight (OR 1.32 [1.14; 1.52]). We further stratified the analysis by sleep duration since we found an interaction between sleep duration and SFI (p < 0.001). In children with recommended sleep duration (n = 8070), we yielded similar results as in the whole group. In children who slept more than recommended (n = 191), high consumers had a higher risk for overweight (OR 3.31 [1.30; 8.42]) compared with normal-weight children. Our results suggest that consuming sugary foods with high frequency is not associated with overweight, except in those sleeping more than recommended. Association between low consumption frequency and overweight may imply that overweight children's consumption frequency of sugary foods is controlled, restricted, or under-reported because of social desirability.
Malnutrittion among Dutch children? Results of the Dutch national food consumption survey 2012–2016
Authors: van Rossum Caroline , Verkaik-Kloosterman Janneke , Brants Henny , Ocké Marga 
Published: June 2020

AbstractIntroduction:An adequate and balanced intake of energy and nutrients is important for growth of children and prevention of diseases. The aim of this study was to get insight in the prevalence of low and high intakes of micronutrients and its association with overweight among Dutch children. This insight can contribute to the development of policy on healthy diet and specific nutritional information.Materials and methods:Food and supplement consumption data of children 1–18 years (n = 2.235) were collected in 2012–2016 with two independent 24-hr recalls. Body Mass Index (BMI) was based on measured body height and weight for 1–15 year-olds, and self-reported values for 16–18 year–olds. Using the Dutch food and supplement composition tables, the habitual nutrient and energy intake distribution were estimated and evaluated with the dietary reference values of the Dutch Health Council. Analyses were performed for the total group as well as for classes of BMI.Results:The intake of most micronutrients was sufficient for the children until the age of 13. No statement on this can be made for the intake of iron and vitamin D (girls). For the Dutch teenagers, low intakes of vitamin A (43%), iron (10% of the boys and 77% of the girls) and vitamin C (18%) were observed. For many other nutrients (calcium, potassium, magnesium, iron, zinc, vitamins B1, B2, B6, D, K1 and folate) the risk of low intakes among (subgroups of) teenagers were evaluated as ‘unknown’, as the median intakes were lower than the adequate intakes. In all age groups, the intakes of copper and vitamins B3 and B12 were sufficient.At the same time, the majority of the children (72% of the boys and 50% of the girls) had a high intake of sodium and a small number of children had high intakes of zinc (7%), copper (3%) or vitamin A (4% of the boys).17% of the children had overweight or obesity and for 9% the weight was evaluated as underweight. The prevalence of low intakes of vitamins A, D and iron was associated with BMI.Discussion:This study suggests that the food consumption of Dutch children can be improved with a more balanced intake of energy and nutrients to prevent obesity and low and high intakes. However, not for all nutrients the health impact is clear. So, more research on the nutrient requirements among children and the related health impact is necessary.
Acute effects of apple extracts with different polyphenol compositions on glucose transport in human intestinal cell line Caco-2/TC7
Authors: Prpa Emily , Corpe Christopher , Hall Wendy 
Published: June 2020

AbstractDiets with a high-glycaemic load may increase the risk of type 2 diabetes. Food and beverages containing large amounts of highly bioaccessible starch and sugars induce pronounced postprandial blood glucose concentrations. Chronic exposure to sharp blood glucose peaks can lead to oxidative stress and pancreatic beta-cell dysfunction. Fruit polyphenols may help to limit the glucose excursion following a high-carbohydrate meal.Our previous research showed that 1.8 g polyphenol-rich apple extract (AE) mixed into a drink consumed before a high starch + sucrose meal, inhibited the incremental area under the curve of plasma glucose during the early absorption-driven postprandial phase (0–30 min) by 52% relative to a placebo drink and meal. Our latest dose-response trial showed that the glycaemic response to starch and sucrose was modified by 0.9 g AE. Possible mechanisms include activity inhibition of carbohydrate digestive enzymes and/or glucose absorption (SGLT1/GLUT2 transport). The AE is uniquely high in phlorizin (10.6%) – a strong inhibitor of SGLT1. However, evidence shows that other apple polyphenols may also inhibit SGLT1.The primary aim of our work was to explore the effect of different mixtures of apple polyphenols on gut transporters involved in glucose uptake. Acute dose-response effect of the AE and three fractions of AE (20%, 40% and 80% methanol elution during fractionation) on total glucose transport were investigated in Caco-2/TC7 cells. Uptake media (10min) contained, except for controls, increasing concentrations of AE/fractions (0–4.5mg/ml) incorporating the physiological range estimated to be present in the small intestine after ingestion of clinical trial test drinks. Glucose transport under sodium-dependent conditions was determined by radiochemical detection of Glucose D-[14C(U)] and Glucose L-[1-14C].A 47% decrease in total glucose uptake was observed with 1.12mg/ml AE (i.e. clinical trial highest physiological dose) v control (P = 0.03). Dose-response experiments showed IC50were: 1.29 mg/ml, 0.31 mg/ml and 0.88 mg/ml for AE (mg/g: 79 phlorizin; 26 epicatechin; 4 quercetin), 80% fraction (mg/g: 101 phlorizin; 26 epicatechin; 38 quercetin), 40% fraction (mg/g: 83 phlorizin; 20 epicatechin; 7 quercetin), respectively. The 20% fraction (mg/g: 4 phlorizin; 12 epicatechin; 2 quercetin) had no effect on glucose transport.We have gained greater understanding of a potential mechanism for the anti-hyperglycaemic properties of apple polyphenols, supporting potential applications of the AE in functional foods/beverages. Our in vitro data suggest that a combination of higher amounts of phlorizin and quercetin may be important to maximise intestinal glucose uptake inhibition.
Anti-platelet and anti-inflammatory properties of an ethanol-water red grape pomace extract
Authors: Choleva Maria , Tsota Maria , Boulougouri Vassiliki , Panara Anthi , Thomaidis Nikolaos S. , Antonopoulou Smaragdi , Fragopoulou Elizabeth 
Published: June 2020

AbstractPrevious reports support that wine contains a mixture of micro-constituents in a proper quality and quantity that possess cardio-protective effect partly through Platelet-Activating Factor (PAF) inhibition. Grape pomace (GP) is a source of wine-like micro-constituents that may be a suitable alternative in food fortification. Limited data exist concerning their effects on thrombosis and inflammation. Therefore, the purpose of this study was to examine a grape pomace extract regarding its anti-platelet and anti-inflammatory properties. GP from four red grape varieties were extracted with 80% ethanol (GP:solvent 1:5w/v). The extract's total phenolic compounds were evaluated and the phenolic profile was performed by Ultrahigh-Performance-Liquid-Chromatography coupled to Mass-Spectrometry and the determination of fatty acids profile was performed by Gas-Chromatography. The extract's anti-platelet properties were tested in healthy volunteers’ platelet rich plasma by the light transmittance method, against three agonists: PAF, ADP and TRAP. The results expressed as IC50 values (μg of extract that cause 50% inhibition of aggregation) and EC50 values (agonist concentration that causes 50% of the maximum aggregation) in the extract's presence and absence. Concerning the extract's anti-inflammatory properties, peripheral blood mononuclear cells from healthy volunteers were pre-incubated with different extract concentrations, which were tested for their effect on cell viability, for 1 h and then stimulated with LPS for 4 h. Secretion of IL-1β and TNF-a was measured and normalized with the total cell protein. Phenolic compounds were calculated at 8.79 ± 1.17 mg gallic acid per g of GP. The most abundant ones were catechin, epicatechin and quercetin at 202.9 ± 6.9, 84.8 ± 1.5 and 83.7 ± 3.5μg per g of GP respectively. Out of the 18 fatty acids detected, the most abundant ones were palmitic, oleic, linoleic, and linolenic acid at 28.7 ± 0.1, 11.4 ± 0.01, 32.5 ± 0.07, 12.7 ± 0.005 g per 100 g of fat. The extract's IC50 was calculated at 162.1 ± 66.9, 181.2 ± 82.3 and 156.3 ± 97.5μg against PAF, ADP and TRAP, respectively. The EC50 values in the presence of 150μg extract were increased (lower platelet aggregation sensitivity) approximately at 100%, 45% and 13% against PAF, ADP and TRAP respectively, compared to EC50 values in the absence of extract. The presence of 500 and 1000μg/mL of extract reduced LPS-induced TNF-a secretion at approximately 38.2% (p = 0.04) and 6.0% (p < 0.000), respectively. Potent anti-platelet and anti-inflammatory properties are combined in a grape pomace extract. The use of its bioactive micro-constituents is likely to lead to the production of functional foods with cardioprotective properties.
Soybean oil attenuates the onset of non-alcoholic steatohepatitis and insulin resistance
Authors: Sanchez Victor , Engstler Anna Janina , Brandt Annette , Jin Cheng Jun , Rajcic Dragana , Jung Finn , Nier Anika , Baumann Anja , Bergheim Ina 
Published: June 2020

AbstractBackground and Aims:General overnutrition, and a diet rich in fat and sugar are among the key risk factors for the development of metabolic diseases including diabetes type 2 and non-alcoholic fatty liver diseases (NAFLD). While being among the most commonly consumed oils world-wide, the effects of soybean oil on the development of metabolic diseases are yet not understood. Indeed, existing data is in part contradictory. Based on this background, the aim of the present study was to investigate the effects of soybean oil consumption on the development of non-alcoholic steatohepatitis (NASH), the more progressed stage of NAFLD, and insulin resistance.Methods:Female C57BL/6J mice were fed either a liquid standard control diet (C) or a liquid fat-, fructose- and cholesterol-rich diet (FFC, 25E% butterfat, 50% (wt/wt) fructose, 0.155% (wt/wt) cholesterol) or a FFC supplemented with soybean oil (FFC + S, 21E% butterfat + 4E% soy oil), with FFC and FFC + S-fed groups being pair fed for 13 weeks to induce steatohepatitis. After 7 and 12 weeks of feeding, a glucose tolerance test was performed. Indicators of liver damage, inflammation, intestinal barrier function and markers of insulin signaling cascade were measured in intestinal, liver and muscle tissue.Results:As expected FFC-fed mice developed early signs of NASH and insulin resistance. Despite similar caloric intake and body weight gain, development of NASH and insulin resistance were significantly attenuated in FFC + S-fed mice when compared to FFC-fed animals. Indeed, signs of hepatic inflammation e.g. number of inflammatory foci and neutrophils as well as activity of transaminase in plasma were almost at the level of control in FFC + S-fed mice. Prevalence of macrovesicular steatosis being the predominant type of fat accumulation found in FFC-fed animals was also markedly lower in FFC + S-fed mice. Furthermore, while in muscle and liver tissue of FFC-fed mice insulin receptors mRNA expression was significantly different from C-fed animals, insulin receptors expression in FFC + S-fed mice was almost at the level of controls. The protective effects of soybean oil supplementation on the development of metabolic alterations were associated with a protection against the induction of TLR4 mRNA expression and dependent signaling molecules in liver tissue.Conclusion:Taking together, our results indicate that supplementation with soybean oil may attenuate the development of diet-induced NASH and insulin resistance in mice and that this may be related to alteration of TLR4-dependent signaling cascade in liver tissue. (Funded in parts by UFOP e.V.)