bluuebunny/crossref_metadata_2025_split huggingface dataset:
PHYSIOCHEMICAL PROPERTIES AND ACE INHIBITORY CAPACITY OF HAZELNUT PROTEIN ISOLATE AND HYDROLYSATES
Authors: EROGLU EVREN CAGLAR , Oztop Kamuran , Aksay Salih 
Published: September 2020

Protein solubility, water holding capacity, fat absorption capacity, emulsion activity index, emulsion stability index, gel formation capacity and Angiotensin-Converting Enzyme (ACE) inhibitory capacity of hazelnut protein isolate (HPI) and its hydrolysate were determined. The results showed that protein solubility had U shape solubility profile with an isoelectric point at pH 4.5-5 and highest value at pH 2 and pH 10. Water holding capacity and fat absorption capacity of HPI was found as 1.95 mL water/g protein and 2.1 g fat/g protein, respectively. Emulsion activity index and emulsion stability index values were found as 44 m2/g and 46 min at pH 7.0, respectively. Weak gel formation of HPI was seen at 8% and firm gel (LGC) was observed at 12% protein concentration. The concentration of pepsin hydrolysates needed to inhibit 50% of the ACE activity values (IC50) at 0, 30, 60 and 120 min of hydrolysis were 1.47 mg protein/mL, 0.27 mg protein/mL, 0.27 mg protein/mL and 0.26 mg protein/mL respectively. Whereas, IC50 of trypsin hydrolysates at 0, 30, 60 and 120 min were 5.51 mg protein/mL, 0.61 mg protein/mL, 0.56 mg protein/mL and 0.54 mg protein/mL. These results showed that isolates and hydrolysates of hazelnut has valuable functional properties and noted as good candidates for effectively reducing hypertension.
Functional Movement Screening: An Early Detection of The Student Injury Risk in Sport Class
Authors: Syafei Muhamad , Budi Didik Rilastiyo , Listiandi Arfin Deri , Festiawan Rifqi , Kusnandar Kusnadar , Nurcahyo Panuwun Joko , Stephani Mesa Rahmi , Qohhar Wildan 
Published: September 2020

Physical Education class is one of the solutions taken by regional schools to improve achievements in sports. The process of recruiting physical education class students has mostly conducted by using the talent scouting test method which consists of physical test and skill test. However, the implementation of sport injury detection test using Functional Movement Screening (FMS) is still insignificant. The purpose of this study was to identify the student risk of injury in physical education class by using the FMS test. The research was an ex-post-facto method. The research samples were 32 students of class VIII in the physical education class at SMPN 1 Baturaden (20 males and 12 females) aged 14 years in average. The research instrument used was the Functional Movement Screening (FMS) test with the validity and reliability of 0.81. Data processing and analysis employed the Benchmark Reference (PAN) with the help of Ms. Excel. The results showed that 56.25% of physical education class students at SMPN 1 Baturaden were identified at risk of sports injuries. The results also showed an imbalance of strength between the right and left body muscles. The study concludes that the use of Functional Movement Screening (FMS) test is important to minimize the high likelihood of injury of the students in physical education class.
Ocular side effects of anti-tubercular drugs in patients receiving Anti-Tb treatment at tertiary care center
Authors: Panchal Kruti , M Solu Trupti 
Published: September 2020

India is among the countries that carry the highest burden for tuberculosis. Antitubercular drugs are frequently associated with ocular toxicity. Among ATT, ethambutol is the most commonly implicated drug causing optic neuropathy. For assessing spectrum of ATT induced ocular toxicity, clinical presentation, monitoring, and preventive measures a prospective observational follow up study was conducted.A newly diagnosed drug susceptible pulmonary tuberculosis patients referred to ophthalmology OPD during a study period from May 2018 - October 2019 at a tertiary care hospital. The detailed history, best corrected visual acuity, fundus examination, color vision test and visual fields were carried out in all patients at the start of treatment and thereafter every month up to 6 months after initiation of ATT.During six month follow up study, out of 94 study participants, 14 eyes of seven patients (7.44%) had drop in visual acuity from baseline (p value = 0.03). Total 10 eyes of five patients (5.32%) had developed colour vision abnormality (p=0.001) and 8 eyes of four patients had developed optic disc changes from baseline. Visual field defects were noted in ten (5.32%) eyes (p = 0.001). In our study ATT related ocular toxicity was found in 5.32% on standard HRZE drug regimen.The course of ethambutol-induced ocular toxicity is unpredictable. The early recognition of ocular toxicity is paramount to prevent irreversible visual loss.
Nursing Students Attitude Towards Teenage Pregnancy
Authors: Emanuel-Frith Mickelle , Pitter Cynthia , Agu Chinwendu Felicia 
Published: September 2020

BACKGROUNDTeenage pregnancy is a multifaceted problem which is influenced by numerous issues including individual, family, and community characteristics. Its consequences affect the health, social and economic wellbeing of the teenagers and their children. The attitudes and behaviors of maternal healthcare providers were an essential component of quality as they impacted both positively and negatively on how the clients, their partners, and families observed and experienced maternal healthcare. This study was conducted to determine the general attitudes of student nurses towards teenage pregnancy and also to determine whether socio-demographic characteristics of the student nurses affected their attitude towards teenage pregnancy.METHODA quantitative descriptive, cross-sectional study was done in 2018. A total of 87 randomly selected fourth year student nurses completed a self-administered questionnaire. The data were analyzed using SPSS (Statistical Package for the Social Sciences). The study was approved by our local ethical boards and all ethical considerations were adhered to.RESULTSThe results of the study revealed that majority of the participants (93.1%) were single and attended church (90.8%). The majority of the sample was female (96.6%) between the ages 18–24 years old. The respondents' attitudes towards teen mothers were not affected by their relationship status, their age or gender or church attendance The results further revealed that the nursing students' had a moderately positive attitude towards teenage pregnancy. The only sociodemographic variable that affected attitude was the respondents having a teen mother in the family. The respondents with a teen mother in the family accounted for 29.9%.CONCLUSIONThis study adds to the body of knowledge on the attitudes of nursing students towards teenage pregnancy. The findings support the nursing curriculum that accentuates patient-centered care, reduce bias, and promotes professional values in Jamaica in order to deliver care to this vulnerable group.
Factors Associated With Timely Initiation of Breastfeeding and Prelacteal Feeding in North-Central Nigeria
Authors: Emmanuel Andy , Clow Sheila Elizabeth 
Published: September 2020

OBJECTIVEDelay in initiation of breastfeeding after birth is associated with the introduction of other feeds. It has been recommended that all women should initiate breastfeeding within the first hour after birth. Early initiation of breastfeeding and exclusive breastfeeding could reasonably reduce neonatal deaths. The aim of this study was to assess the initiation of breastfeeding and prelacteal feeding in Plateau State, Nigeria.MATERIALS AND METHODA cross-sectional design was adopted for the study. A total of 763 women drawn equally from the three senatorial zones of the state voluntarily completed a questionnaire. Results were analyzed using chi-squared statistics and regression analysis.RESULTSFindings show that 33.1% of women initiated breastfeeding in a timely manner. The relationships between the timely initiation of breastfeeding and the use of pain relief, maternal age, maternal employment, economic status, influence of family and friends, and advertisement were found to be statistically significant. Furthermore, 92% gave breast milk for the first feed, while 8% gave infant formula, glucose, herbs, or water. Inadequate breast milk production, delayed initiation of breastfeeding, and health conditions were factors identified as responsible for prelacteal feeding.CONCLUSIONThe proportion of women who initiated feeding in a timely manner was low, which underscores the need to promote and support early initiation of breastfeeding in the state. There is thus a need for a public education campaign, particularly directed at women receiving antenatal care, and focusing on the need for establishing feeding early. Women with health challenges and those with a history of poor milk production may require additional support to breastfeed as recommended.
State Marriage and Civil Marriage: The Role of State Policy on Interreligious Marriage in Central Java
Authors: Lathifah Anthin 
Published: September 2020

This article discusses interreligious marriage in Central Java, especially in Surakarta, Semarang City and Jepara; places where the policies of stakeholders on judicial system, the role of demographic officials and religious leaders heavily influence each other. The policies of the State Court as an institution authorized to determine interreligious marriage vary from one to another area. For example, the Surakarta State Court receives the petition and establishes interreligious marriage, in contrast to the State Court in Semarang and Jepara which deny the petition of interreligious marriage. It is influenced by several things, namely the understanding of the regulation of marriage laws in Indonesia as well as religious understanding and role of its religious leaders. In the context of state and civil society relations, interreligious couples whose petitions are rejected consider it unfair; even those whose petition is accepted also deem it unfair since they regard their marriage as a civil marriage only, not desired by the state.Artikel ini membahas tentang perkawinan beda agama di Jawa Twngah, khususnya di Surakarta, Kota Semarang dan Kabupaten Jepara, tempat-tempat dimana kebijakan para pemangku kepentingan tentang sistem peradilan, peran pejabat demografik dan pemimpin agama saling mempengaruhi satu sama lain. Kebijakan Pengadilan Negeri sebagai lembaga yang berwenang menentukan perkawinan beda agama bervariasi dari satu daerah dengan daerah yang lain. Pengadilan Negeri Surakarta menerima petisi dan menetapkan perkawinan beda agama, berbeda dengan Pengadilan Negeri Kota Semarang dan Kabupaten Jepara yang menolak permohonan perkawinan beda agama. Perbedaan kebijakan tersebut dipengaruhi oleh beberapa hal, yaitu pemahaman tentang peraturan perundang-undangan perkawinan di Indonesia, pemahaman agama dan peran para pemimpin agama. Dalam konteks hubungan negara dan masyarakat sipil, pasangan antara agama yang permohonannya ditolak menganggapnya tidak adil; bahkan mereka yang permohonannya diterima juga menganggap itu tidak adil karena mereka menganggap merkawinannya hanyalah perkawinan sipil, yang tidak diinginkan oleh negara.
IR spektroskopi kullanılarak in vitro meme kanser kök hücrelerinin araştırılması
Authors: GÜLER Günnur , GÜVEN Ümmü , AÇIKGÖZ Eda , ÖKTEM Gülperi 
Published: September 2020

Amaç: Kanser kök hücreleri (KKH), tümör içinde kendi kendilerini yenileme ve diğer hücre tiplerine farklılaşabilme kapasitesi sebebiyle tümörün başlaması, ilerlemesi, nüksetmesi, metastaz ve terapötik dirence yol açmaktadır. Bu nedenle, meme kanser kök hücrelerinin (MKKH) karakteristik özelliklerinin belirlenmesi gerekmektedir. Bu çalışmanın amacı, MKKH‟lerin akış sitometrisi ile izole edildikten sonra Fourier dönüşümlü kızılötesi (FTIR) spektroskopisi kullanarak hücre biyokimyasındaki farklılaşmalarının moleküler seviyede araştırılmasıdır.
Gereç ve Yöntem: MCF-7 meme kanser hücre hattındaki CD44+/CD24- yüzey belirteç özelliği gösteren MKKH‟ler akış sitometrisi ile izole edilmiştir. MCF10A, MCF-7 kanser hücre (KH) hattı ve bu hattan izole edilen CD44+/CD24- yüzey belirteç özelliklerine sahip MKKH‟'ler %0,9 NaCI içerisine resuspanse edildikten sonra FTIR spektrometre ile ölçülmüştür.
Bulgular: MCF-7 içerisindeki CD44+/CD24- yüzey belirteç özelliğine sahip KKH‟lerinin sort oranı %2,0-2,3 olarak belirlenmiştir. Elde edilen FTIR spektrumlarında, MKKH, meme kanser hücreleri (KH, non-KKH, bulk populasyon) ve sağlıklı hücreler arasında spektral benzerlikler ve farklılıklar tespit edilmiştir. MKKH‟lerde lipit ve protein sinyalleri daha güçlü olup hücre zarı akışkanlığı ve dinamiği fazladır. Sağlıklı hücreler ile kıyaslandığında, KH‟lerde α-helikal proteinler ve DNA sinyallerinde azalmaya karşın negatif yüklü karboksil gruplarından kaynaklanan sinyallerde artış gözlenmektedir. Bu veriler, MKKH‟lerin, sağlıklı ve KH‟lere kıyasla yapı, içerik ve dinamiği bakımından oldukça farklı bir profil sergilediğini göstermektedir.
Sonuç: Bu çalışma, MKKH‟lerinin moleküler yapısı ve içeriğindeki değişikliklerin incelemesi vasıtasıyla terapötik hedefli ilaç çalışmaları yapılabileceğini ortaya koymaktadır. FTIR spektroskopisi boyar madde gerektirmeden, hassas ve hızlı ölçüm alınması, örnek hazırlamada kolaylık ve az miktarda örnek gerektirmesi sebebiyle ileri hücre çalışmalarında ve medikal alanda biyolojik örneklerin analizlerinde kullanılabileceği de gösterilmiştir.
Percutaneous repair of Achilles tendon rupture: is it safe and reliable?
Authors: TÜZÜN Harun Yasin , ERŞEN Ömer , TÜRKKAN Selim , ARSENİSHVİLİ Arsen , KÜRKLÜ Mustafa 
Published: September 2020

Aim: Achilles tendon rupture is the most common tendon rupture and the best treatment for acute Achilles tendon ruptures remains controversial. Mini open or percutaneous repair techniques offer early recovery and return to daily life, but have some disadvantages such as sural nerve injury and re-rupture. The aim of this study is to determine the safety and reliability of percutaneous repair of Achilles tendon rupture with identifying and retracting the sural nerve on its anatomical location.
Materials and Methods: Twenty-four patients who had undergone percutaneous Achilles tendon repair between November 2013 and February 2017 were included in this study. Wound healing problems, complications, ankle range of motions, and American Foot and Ankle Society score in early postoperative period and at the last follow-up were assessed.
Results: The average follow up period was 23 months. At last follow up injured ankles had 47.9±3.1° plantar flexion and 20.1±2.6° dorsiflexion statistically similar to the uninjured side. The average AOFAS score was 91±9.6.
Conclusion: Percutaneous Achilles tendon repair is safer and more reliable method when the sural nerve was identified at its anatomical location.
Femur boyun kırıklarında kırık lokalizasyonunun instabilite ile ilişkisi: Biyomekanik çalışma
Authors: YARADILMIŞ Yüksel Uğur , OKKAOĞLU Mustafa Caner , HURİ Pınar , EYİDOĞAN Abdullah , DEMİRKALE İsmail , ALTAY Murat 
Published: September 2020

Amaç: Femur boyun kırıklarında kırık konfigürasyonu ile instabilite arasında ilişki görülmekte iken kırık lokalizasyonu ile instabilite arasındaki ilişki literatürde yer bulmamıştır. Çalışmamız femur boyun kırıklarında, kırığın femur boyun lokalizasyonu ile instabilite arasındaki ilişkiyi araştırdı. Gereç ve Yöntem: Çalışmamızda 12 adet kompozit sentetik proksimal femur modeline üç farklı lokalizasyondan osteotomi yapıldı. Osteotomi lokalizasyonu; transservikal yerleşim (Grup 2), transservikal yerleşimin 5 mm proksimali (Grup 1=Subkapital), transservikal yerleşimin 5 mm distali (Grup 3=Bazoservikal) olmak üzere üç ayrı lokalizasyondan planlandı. Her femur modeli için Pauwels tip II osteotomi ve iki kanüllü vida ile tespit uygulanarak femur modelleri standardize edildi. Gruplara aksiyel yönde stres (kompresyon) uygulanarak stabilite, biyomekanik parametreler ile incelendi.
Bulgular: Stres/strain eğrileri gruplar içinde paralellik gösterdi (p>0,05). Gruplar arası değerlendirmede stres/strain eğrileri Grup 1’de yüksek gözlenirken, Grup 2 ve Grup 3’te eğrilerde paralel gözlendi. Sentetik kemik modellerinde strain değeri 4 olduğunda basınç ölçümleri; Grup 1’de 500±40 N/mm2, Grup 2’de 370±36 N/mm2, Grup 3’te 380±32 N/mm2 (p=0,000), strain değeri 6 olduğunda basınç ölçümleri; Grup 1’de 700±48 N/mm2, Grup 2’de 520±50 N/mm2, Grup 3’te 510±53 N/mm2 olarak ölçüldü (p=0,000). Grup 1 daha stabil gözlenirken, Grup 2 ile Grup 3 arasında fark gözlenmedi.
Sonuç: Femur boyun kırığı biyomekanik çalışmamızda transservikal ve bazoservikal bölge lokalizasyonlarında benzer stabilite gözlenirken, en proksimaldeki, subkapital bölge kırığının daha stabil olduğu gözlendi.
Tirotoksikoz nedenli erektil disfonksiyon üzerine sildenafil etkisinin histopatolojik olarak değerlendirilmesi
Authors: ÖZDEMİR Murat , TOMRUK Canberk , YİĞİTTÜRK Gürkan , EROL Varlık , ÇETİN Emel Öykü , YILDIRIM ŞİMŞİR Ilgın , YENİSEY Çiğdem , UYANIKGİL Yiğit , ŞİMŞİR Adnan , MAKAY Özer 
Published: September 2020

Amaç: Tirotoksikoz, periferik kan ve dokulardaki tiroit hormonu fazlalığından kaynaklı tüm klinik tabloları karşılayan bir çatı terimdir. Tirotoksikoz tablosu birçok organ ve metabolik süreci olumsuz yönde etkilemektedir. Bunlardan biri de erkek üreme sistemidir. Bu deneysel çalışmada tirotoksikoz nedenli erektil disfonksiyonda sildenafil tedavisinin disfonksiyonu önleyebilme etkisinin histopatolojik olarak değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntem: Her biri 8 sıçandan oluşan 4 çalışma grubu oluşturuldu. Bu deneysel gruplar; Kontrol, Tirotoksikoz (Deney grubu), Tirotoksikoz + sildenafil uygulanan grup (Tedavi grubu) ve Tirotoksikoz oluşturulan + sildenafil çözücü solüsyon uygulanan grup (plasebo) grubu şeklindedir. Tirotoksikoz grubu erkek sıçanlara 0,2 mg/kg/gün dozunda ile 7 gün boyunca L-tiroksin enjekte edildi. Tedavi grubuna ise L- tiroksin uygulamasını takiben 10 mg/kg/gün dozda sildenafil, 24 gün boyunca intraperitoneal olarak uygulandı. Deneysel model tamamlanınca penis dokusu histokimyasal ve immünohistokimyasal incelemeler için %4’lük paraformaldehit içine alındı. Rutin immünohistokimyasal takip ve boyamalar yapılarak tüm örnekler ışık mikroskobunda değerlendirildi.
Bulgular: Deney grubuna ait deneklerde kavernöz boşluklarda dejenerasyon, daralma ve endotel hücrelerinde kayıp olduğu saptandı. Fibroelastik bağ doku ve düz kas dağılımı açısından tirotoksikoza maruz kalan sıçanlarda elastik lifler ve düz kaslarda belirgin azalma, kollajen liflerde ise artış olduğu saptandı. Tedavi grubunda tunica albuginea, corpus cavernosum, venöz sinüsler, kavernozal trabeküler düz kas ve ince fibröz bağ doku normal histolojik yapıya yakın olduğu görüldü. Kavernöz cisimlerin çapları istatistiksel olarak anlamlı bulundu (p
La realidad de la práctica escolar y el deseo de interculturalidad. La enseñanza de quechua en colegios particulares en Cochabamba, Bolivia
Authors: Sichra Inge 
Published: September 2020

Este trabajo tiene como objetivo detectar en qué medida la enseñanza del quechua aporta a la interculturalización de alumnos castellano monolingües de dos colegios particulares que han incorporado la lengua indígena en su currículo. La premisa que sustenta la investigación establece que los procesos pedagógicos son producto de ideología y generan ideología. Para romper el ciclo de reproducción de la posiciones hegemónicas transmitidas como ideología, “las teorías críticas se proponen lograr que los ‘agentes’ tomen conciencia de la coerción oculta, y por ello, tratan de liberarles de dicha coerción y colocarles en una situación que les permita determinar en dónde residen sus verdaderos intereses” (Wodak 2003, p.34). Presentamos a continuación las opiniones de niños y padres de familia de colegios particulares respecto a la importancia del quechua en un contexto de conflictos sociales y las contrastamos con los referentes culturales que los niños reciben en el aula durante las clases de quechua. Las conclusiones apuntan, entre otras, a la sorprendente ideología progresista expresada por los padres de familia y alumnos que favorecería la interculturalización como efecto de la enseñanza de quechua en el colegio, en contraste con la práctica de aula. Esta práctica encasilla la lengua indígena en el mundo rural, la aísla en un mundo estático y alejado de toda actualidad, difundiendo a la vez prejuicios respecto a los hablantes y su cultura.
UM OLHAR ETNOGRÁFICO SOBRE OS DISCURSOS ECUMÊNICOS RELACIONADOS A MISSÕES, DESENVOLVIMENTO E POVOS INDÍGENAS
Authors: Barroso Maria Macedo 
Published: September 2020

O artigo aborda os debates dentro do campo ecumênico protestante relacionados à definicação dos povos indígenas como sujeitos de direito na cena política contemporânea, examinando esta temática em sua relação com o campo da cooperação para o desenvolvimento. O argumento é construído a partir da constatação do peso dos aotres religiosos no aparato da cooperação, buscando-se identificar os discursos que têm dado suporte tanto a ações no terreno da advocacy quanto a intervenções voltadas a projetos de desenvolvimento junto aos povos indígenas. Para isto, realiza uma etnografia da Pré-Assembléia Indígena conduzida na X Assembleia do Conselho Mundial de Igrejas na Coréia do Sul, em 2013.
Real-Life International Normalized Ratio Profile in Patients with Non-Valvular Atrial Fibrillation Prescribed Vitamin K Antagonist
Authors: Farag S. I. , Arafa O. S. , Hassan A.A. E. , Mashhour H. M. , Bendary A. M. 
Published: September 2020

Coagulation status with vitamin K antagonists (VKAs) needs to be monitored carefully to ensure maximal efficacy with minimal complication rates.Aim. To study the international normalized ratio (INR) values in patients on VKAs in selected area, find out which patient characteristics that is associated with good INR control and calculation of the time in the therapeutic range (TTR) according to the number of INR/Patient.Material and methods. A total of 200 patients with non-valvular atrial fibrillation prescribed vitamin K antagonist as anticoagulant were evaluated. They were divided into two groups: group I with TTR≥65% (n=93) and group II with TTR<65% (n=107). Stroke and hemorrhagic risks were calculated by means of the CHA2DS2-VASc score and HAS-BLED score, respectively. Presence of comorbid diseases was assessed by the Charlson index. TTR was calculated using Rosendaal method.Results. Patients in group I (TTR≥65%) were younger (p<0.001), more often men (p<0.074) with a high level of education (p<0.001), had lower stroke and hemorrhagic risks (mean CHA2DS2-VASc score was 1.0 and HAS-BLED score – 0.0), and also had fewer comorbidities (mean Charlson index was 0.0; p<0.001) compared to patients in group II (TTR<65%). The rate of inadequate control with VKAs (TTR<65) was 52%. Multivariate logistic regression analysis was done to see the significant independent predictors for a good INR control i.e. TTR≥65%. It was found that high level of education compared to lower levels is the only significant independent predictor for obtaining good INR control (odds ratio=133, 95% confidence interval 34.24-514.44, p<0.001).Conclusion. It was found that high level of education compared to lower levels is the only significant independent predictor for obtaining good INR control.