bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of risk features for complication in Gaucher’s Disease patients: A Machine Learning analysis of the Spanish Registry of Gaucher Disease.
Authors: Andrade-Campos Marcio M , de Frutos Laura López , Cebolla Jorge J , Serrano-Gonzalo Irene , Medrano-Engay Blanca , Roca-Espiau Mercedes , Gomez-Barrera Beatriz , Pérez-Heredia Jorge , Iniguez David , Giraldo Pilar 
Published: July 2020

Abstract
Background
Since enzyme replacement therapy (ERT) for Gaucher disease (GD) (MIM#230800) has become available, both awareness of and the natural history of the disease have changed. However, there remain unmet needs such as the identification of patients at risk of developing bone crisis during therapy and late complications such as cancer or parkinsonism. The Spanish Gaucher Disease Registry (SGDR) has worked since 1996 to compile demographic, clinical, genetic, analytical, imaging and follow-up data from more than 400 GD patients. The aims of this study were to discover correlations between patients’ characteristics at diagnosis and to identify risk features for the development of late complications; for this a machine learning approach involving network and decision trees analysis was applied.
Results
A total of 358 GD patients, 340 GD1 and 18 GD3 cases were selected. 18% were splenectomyzed and 39% had advanced bone disease. 81% of cases carried heterozygous genotype. 47% of them were diagnosed before the year 2000. Mean age at diagnosis and therapy were 28 and 31.5 years old (y.o.) respectively. 4% developed MGUS or Parkinson Disease, 6% cancer, and 10% died before this study. Previous splenectomy correlates with the development of skeletal complications and severe bone disease (p = 0.005); serum levels of IgA, delayed age at ERT start (> 9.5 y.o.since diagnosis) also correlates with severe bone disease at diagnosis and with the incidence of bone crisis during ERT. High IgG (> 1750 mg/dL) levels and age over 60 y.o. at diagnosis were found to be related with the development of cancer. When modelling the decision tree, patients with a delayed diagnosis and therapy were the most severe and with higher risk of complications.
Conclusions
Our work confirms previous observations, highlights the importance of early diagnosis and therapy and identifies new risk features such as high IgA and IgG levels for long-term complications.
Locking plate for cubitus varus correction in osteogenesis imperfecta: a case report of 7 year-old girl
Authors: Hong Pan , Liu Ruikang , Rai Saroj , Xu Ruijing , Li Jin 
Published: July 2020

Abstract
Background
Cubitus varus deformity is a common complication of supracondylar fractures in children. However, cubitus varus in osteogenesis imperfect (OI) children is a rare but challenging situation. To the author’s knowledge, it is the first study discussing the correction of cubitus varus deformity in OI patient. Here we report a case of an 7-year-old OI girl who presented with varus deformities of the bilateral lower extremities and cubitus varus deformity of the left elbow due to a supracondylar fracture of humerus 3 year ago. The patient’s parent gave a history of supracondylar fracture of left humerus 3 years ago. Without medical intervention, the patient was admitted into our institution for corrective surgery with the diagnosis of osteogenesis imperfecta and cubitus varus deformity in the left arm.
Result
Medications including calcium, vitamin D and bisphosphonates were administered before the corrective surgery of cubitus varus, and a single locking plate was used to after the osteotomy. Right after the surgery, the appearance and ROM of the left arm was almost normal. Combined with gradual rehabilitation, the ROM of the left arm was normal without pain during daily use. The hardware was removed as the nailing of the forearm fractures was performed at the same time.
Conclusion
Cubitus varus is a common deformity in children resulting from elbow injuries, but it presents a challenging situation in OI patients. Locking plate combined with meticulous pharmacological intervention provides a good option for corrective surgery of cubitus varus in OI.
A Novel Nomogram to predict survival of patients with choroidal melanoma
Authors: Wang Zhong-Yuan , Wei Ting-Ting , Zhu Ling-Peng , Wang Wen-Juan , Gu Lan-Xin , Chen Yin-Zi , Zhang Meng-Yuan , Xie Tian-Hua , yao yong 
Published: July 2020

Abstract
Aim

The purpose of this study is to develop and validate a prediction model of overall survival (OS) in choroidal melanoma patients.
Methods

A total of 3415 patients with choroidal melanoma from 2004 to 2015 were collected from the Surveillance, Epidemiology, and End Results database. A novel nomogram was built based on independent risk factors evaluated by Cox proportional hazards regression model. And internal validations were performed to assess the performance of our nomogram by concordance index (C-index), calibration plot and decision curve analysis (DCA).
Results

Seven factors (age at diagnosis, race, sex, American Joint Committee for Cancer (AJCC) primary tumor (T) category, histological type, marital status and total number of primary tumors) were prognostic factors of OS. These factors were used to conduct a prediction model. The predictive accuracy of the nomogram for the OS has been stable at about 0.72 from 36 to 60 months evaluated by C-index. The calibration plots showed that the OS was also consistent between prediction and actual observation. Moreover, the DCA indicated our nomogram had better net benefit than the T-category.
Conclusion

The nomogram predicting the OS of choroidal melanoma may assist clinicians to decide treatment options individually.
Long-term outcome of polymethylmethacrylate-augmented screw fixation in the treatment of thoracolumbar spinal tuberculosis in elderly patients with severe osteoporosis
Authors: Yang Jun-Song , He Bao-Rong , Wei Jian-Min , Wang Xiang-Fu , Wei Dongmei , Gong Han-Lin , Chen Hao , Gong Long-Gang , Zou Peng , Li Qing-Da , He Li-Min , Hao Ding-Jun , Zhao Yuan-Ting , Chu Lei 
Published: July 2020

Abstract
Background: to evaluate the safety and efficacy of Polymethylmethacrylate-augmented screw fixation (PASF) in the treatment of elderly patients with thoracolumbar spinal tuberculosis accompanied with severe osteoporosis.Methods: 34 elderly patients with thoracolumbar spinal tuberculosis accompanied with severe osteoporosis underwent PASF after anterior or posterior debridement and bone grafting in our hospital from January 2010 to January 2012. The follow-ups were performed at 1, 3, 6, and 12 months postoperatively and then annually thereafter. The segmental cobb angle was measured to evaluate kyphosis improvement. The laboratory examination including ESR and CRP was also monitored. The pre- and postoperative VAS score, ODI score, and neurological function of ASIA scale were also recorded.Results: The included 21 patients completed the operation successfully. In all patients with neurological dysfunction, the ASIA grade improved by at least 1 grade. One month postoperatively, the VAS score, ODI, segmental Cobb angle, ESR, and CRP were significantly improved compared with those preoperatively (P<0.05); there was no significant difference in the values at 1 month postoperatively and last follow-up (P＞0.05). There were no complications such as implant failure, proximal junctional kyphosis, or recurrence of tuberculosis at the minimum 5-year follow-up. Conclusion: For elderly patients with thoracolumbar spinal tuberculosis complicated with severe osteoporosis, after anterior or posterior debridement and bone grafting, together with postoperative systematic anti-tuberculosis and anti-osteoporosis treatments, PASF is safe and effective without catastrophic complications such as intraspinal cement leakage. During the 5-year follow-up, there was no tuberculosis recurrence or implant failure.
Current Status and Related Factors of Turnover Intention of Primary Medical Staff in Anhui Province, China: A Cross-Sectional Study
Authors: Chen Guimei , Sang Lingzhi , Rong Jian , Yan Huosheng , Liu Hongzhang , Cheng Jing , Wang Li , Ding Hong , Chen Ren 
Published: July 2020

Abstract
Background This study aimed to explore the current status of turnover intention and its relationship with psychological capital, social support, and job burnout, as well as how these factors influence turnover intention of primary medical staff in Anhui province, China.Methods We used structured questionnaires to collect data, including demographic characteristics, turnover intention, psychological capital, social support, and Chinese Maslach Burnout Inventory scale. A total of 1,152 primary medical workers of Anhui were investigated. Data were analyzed by t-test, analysis of variance (ANOVA), Pearson correlation analysis, and multiple linear regression model.Results Total scores of turnover intention, psychological capital, social support, and job burnout of subjects were 14.15 ± 4.35, 100.09 ± 15.98, 64.93 ± 13.23 and 41.07 ± 9.437, respectively. Multiple linear regression showed the related factors of turnover intention were age, job position, work unit, and scores of job burnout. Pearson correlation showed psychological capital and social support were negatively correlated with turnover intention, while the score of job burnout was positively correlated with turnover intention.Conclusion The improvement of psychological capital and social support and the reduction of job burnout may play an important role in reducing turnover intention of primary medical staff. Primary medical managers should strengthen the humanistic care for primary medical staff, optimize the incentive mechanism, and improve internal management of medical institutions for stability.
Schistosomiasis, Upper Gastrointestinal Bleeding, and Health Related Quality of Life Measurements in Rural Africa
Authors: Opio Christopher Kenneth , Kazibwe Francis , Rejani Lalitha , Kabatereine Narcis B , Ocama Ponsiano 
Published: July 2020

Abstract
Introduction Health related quality of life (HRQOL) measurements, which include disability weights, are important endpoints of health care delivery. These measurements are scarce for patients with upper gastrointestinal bleeding (UGIB) in rural sub-Saharan Africa (SSA) where schistosomiasis is endemic. Methods and materials In 2014, we studied HRQOL measurements among patients with UGIB in SSA where schistosomiasis is endemic. Participants included adult inpatients and outpatients with a history of UGIB at a primary health facility. We measured HRQOL using the EuroQoL 5-dimension (EQ-VAS/EQ5D) instrument and derived disability weights from EQ-VAS and EQ5D measurements. We profiled each participant’s medical history, physical examination, laboratory tests, imaging, and endoscopy findings. These were summarized through descriptive and inferential statistics.Results We studied 107 participants with a median age of 45 years. All participants experienced ≥1 lifetime episode of UGIB, 60% were females, while 22% had acute severe UGIB requiring admission, 98% hepatic schistosomiasis, 90% splenomegaly, 80% had esophageal varices, and 20% had peptic ulcers. Most (80%) had ever received praziquantel for schistosomiasis. No participant had ever had an endoscopy for UGIB or received propranolol for prevention of recurrent variceal UGIB. Measures of the 5 dimensions of health revealed a large proportion of participants had problems related to self-care (76%), anxiety/depression (88%), and pain/discomfort (89%). Few participants had problems with mobility(37%). The mean/median EQ-VAS derived disability weights and EQ5D derived disability weights were 0.38/0.30 and 0.38/0.34, respectively. Participants with ascites, acute UGIB, and severe anemia were found to have the highest EQ-VAS and EQ5D median disability weights. At linear regression age, female gender, ascites, and acute UGIB predicted EQ-VAS derived disability weights [F(4,100)=9.35, p<0.0000,R-squared =0.27] and EQ5D derived disability weights [F(4,100)=23.24, p<0.0000, R-squared =0.44]. Within these models, all four factors were significantly predicted higher disability weights, P-value <0.05. Conclusions In our study, older age, female gender, those with ascites or acute UGIB had the highest disability weights, and the greatest probability of having higher disability weights among patients with a history of UGIB where schistosomiasis is endemic. These findings are unique and improve the definitions of different health states among patients with UGIB and schistosomiasis.
WITHDRAWN: Perceptions of students regarding the delivery of Sexual and Reproductive Health Education in schools in Fiji
Authors: Ram Sharan , Mohaammadnezhad Masoud 
Published: July 2020

Abstract
Background: Adolescent Sexual and Reproductive Health (SRH) remains a challenge globally. High school youths without Comprehensive Sexuality Education (CSE), are more likely to engage in high risk sexual behaviors than their peers in schools with CSE. Fiji continues to have very poor adolescents SRH indicators. This study aimed to gauge the perceptions of students towards the delivery of SRH education in schools in Fiji. Methods: A qualitative study design was used to collect data from students in Year 11-13 in public secondary schools in Suva, Fiji in 2018. Schools with equal ethnic mix were selected. A semi-structured open–ended questionnaire was used to guide Focus Group Discussions (FGDs). A male research facilitator conducted FGD with males while a female research facilitator facilitated that amongst the females. Data collected was analyzed thematically. Results: Seven FGDs were conducted. A total of 46 students (29 males) participated with the age range from 17-19 years old. Eight themes emerged: current SRH education; students’ knowledge on adverse consequences of SRH; sources of SRH information; need for sex education; provision of SRH education in schools; characteristics of teachers of SRH education; age-appropriate incremental sex education; and ideal version of SRH. Conclusions: The study shows that Fijian students desired a lot more from sex education than what is currently offered for sexual decision-making. There is a need for mandatory and comprehensive sex education for young people.
A Single-center Comparison Using Exoskeleton Rehabilitation for Cerebrovascular Accidents and Traumatic Brain Injury in a Cohort of Hispanic Patients
Authors: Treviño Lisa R , Vatcheva Kristina , Auer Michael E , Morales Angela , Abdurrahman Lama M , Viswamitra Sarajova , Torres-Reveron Annelyn 
Published: July 2020

Abstract
Background

Traumatic brain injury (TBI) is one of the leading causes of disability in the United States. The EKSO GT Bionics® (EKSO®) is a robotic exoskeleton approved by the Federal Drug Administration (FDA) for rehabilitation following a cerebrovascular accident (CVA or stroke) and recently received approval for use in patients with TBI. The aim of the study was to examine if the use of exoskeleton rehabilitation in patients with TBI will produce beneficial outcomes.
Methods

This retrospective chart-review reports the use of the (EKSO®) robotic device in the rehabilitation of patients with TBI compared to patients with CVA. We utilized data from a single, private rehabilitation hospital for patients that received post-CVA or post-TBI robotic exoskeleton intervention. All patients that used the exoskeleton were discharged from the hospital between 01/01/2017 to 04/30/2020. Ninety-four percent of patients in the CVA groups and 100% of patients in the TBI group were of Hispanic or Latino ethnicity. Gains in total Functional Independence Measure (FIM), walking and cognition, and length of stay in the rehabilitation facility were measured.
Results

Patients in the TBI group (n = 11) were significantly younger than the patients in the CVA group (n = 66; p < 0.05). Both groups spent a similar amount of time active, number of steps taken, and the number of sessions in the exoskeleton. Both groups also started with similar admission FIM scores. The FIM gain in the TBI group was similar to that of the CVA group (37.5 and 32.0 respectively). The length of stay between groups was not different either.
Conclusions

The use of exoskeleton rehabilitation in patients with TBI appear to produce similar outcomes as for patients with CVA, prompting further attention of this intervention for this type of injury. Trial registration: Retrospectively registered on 07/09/2020 in clinicaltrials.gov number NCT4465019.
Cognitive and Motor Deficits Contribute to Longer Braking Time in Stroke
Authors: Lodha Neha , Patel Prakruti , Shad Joanna M , Casamento-Moran Agostina , Christou Evangelos A 
Published: July 2020

Abstract
Braking is a critical determinant of safe driving that depends on the integrity of cognitive and motor processes. Following stroke, both cognitive and motor capabilities are impaired to varying degrees. The current study examines the combined impact of cognitive and motor impairments on braking time in chronic stroke. METHODS: Twenty stroke survivors and 20 aged-matched healthy controls performed cognitive, motor, and simulator driving assessments. Cognitive abilities were assessed with processing speed, divided attention, and selective attention. Motor abilities were assessed with maximum voluntary contraction (MVC) and motor accuracy of the paretic ankle. Driving performance was examined with the braking time in a driving simulator and self-reported driving behavior. RESULTS: Braking time was 16% longer in stroke group compared with the control group. The self-reported driving behavior in stroke group was correlated with braking time (r = -0.53, p = 0.02). The stroke group required significantly longer time for divided and selective attention task and showed significant decrease in motor accuracy. Together, selective attention time and motor accuracy contributed to braking time (R2 = 0.40, p = 0.01) in stroke survivors. CONCLUSIONS: This study provides novel evidence that decline in selective attention and motor accuracy together contribute to slowed braking in stroke survivors. Driving rehabilitation after stroke may benefit from the assessment and training of attentional and motor skills to improve braking during driving.
Improvement Of Surgical Complications Using Single-Lumen Endotracheal Tube Intubation And Artificial Carbon Dioxide Pneumothorax In Esophagectomy: A Meta-analysis
Authors: Chuang Kai-Hao , Lai Hsing-Hua , Chen Yu , Chen Li-Chun , Lu Hung-I , Chen Yen-Hao , Li Shau-Hsuan , Lo Chien Ming 
Published: July 2020

Abstract
Background: Esophageal cancer has a poor prognosis. Surgery is the main treatment but involves a high risk of complications. Some surgical strategies have tried to eliminate complications. Our meta-analysis tried to find the benefits of single-lumen endotracheal tube intubation with carbon dioxide (CO2) inflation. Methods: A systematic search of studies on esophagectomy and CO2 inflation was conducted using PubMed, Medline, and Scopus. The odds ratio of post-operative pulmonary complications and anastomosis leakage were the primary outcomes. The standardized mean difference (SMD) in post-operative hospitalization duration was the secondary outcome. Results: The meta-analysis included four case-control studies with a total of 1503 patients. The analysis showed a lower odds ratio of pulmonary complications in the single-lumen endotracheal tube intubation in the CO2 inflation group (odds ratio: 0.756 [95% confidence interval, CI: 0.518 to 1.103]) compared to that in the double-lumen endotracheal tube intubation group, but anastomosis leakage did not improve (odds ratio: 1.056 [95% CI: 0.769 to 1.45])). The SMD in hospitalization duration did not show significant improvement. (SMD: -0.141[95% CI: -0.248 to -0.034]). Conclusions: Single-lumen endotracheal tube intubation with CO2 inflation improved pulmonary complications and shortened the hospitalization duration. However, no benefit in anastomosis leakage was observed.
Network Pharmacology Study Reveals the Mechanism of Astragali Radix in Treatment of Diabetic Nephropathy
Authors: Tian Chongmei , Chen Jing-bai , Chen Xiang , Xia Dao-zong 
Published: July 2020

Abstract
Background

Diabetic nephropathy (DN), a unique complication of diabetes, could contribute to an increase in mortality. In this study, we predicted and proved the molecular pharmacological mechanism concerning the protective effects of Astragali Radix on DN.
Methods

The same potential target genes from Astragali Radix and DN were analyzed and constructed the protein interaction network. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment-related major targets and signal pathways were performed. The drug-ingredients-target-disease network was visually built using Cytoscape 3.6.1. The beneficial pharmacological activities of quercetin from Astragali Radix were confirmed by CCK-8 assay, determination of antioxidant parameters and Western blotting analysis.
Results

There are 12 bioactive components from Astragali Radix and 56 same targets between Astragali Radix and DN. The GO analysis results showed that the biological processes mainly included protein homodimerization activity. KEGG analysis indicate that the screened targets were most closely linked to the mitogen-activated protein kinase (MAPK) signaling pathway. The drug-ingredients-target-disease network results revealed that the therapeutic effects of Astragali Radix mainly included oxidative stress, inflammatory reaction and apoptosis. During the verification process, quercetin from Astragali Radix could attenuate cytotoxicity, enhance catalase (CAT) and superoxide dismutase (SOD) activities and suppress MAPK signaling pathway.
Conclusions

In the current study, network pharmacology with experimental analysis predicted and proved the therapeutic function of Astragali Radix by improving antioxidant capacity and suppressing MAPK signaling pathway, these investigations could provide a new perspective for further exploration of Astragali Radix on DN treatment.
Bardoxolone-Methyl (CDDO-Me) impairs tumor growth and radioresistance of oral squamous cell carcinoma (OSCC) cells via accumulation of reactive oxygen species
Authors: Hermann C , Lang Simon , Popp Tanja , Hafner Susanne , Steinritz Dirk , Rump Alexis , Port Matthias , Eder Stefan 
Published: July 2020

Abstract
Radiotherapy (RT) represents a common treatment strategy for patients suffering from oral squamous cell carcinoma (OSCC). However, application of RT is immanently limited by radio-sensitivity of normal tissue surrounding the tumor sites. In this study, we used normal human epithelial keratinocytes (NHEK) and OSCC cells (Cal-27) as models to investigate radio-modulating and anti-tumor effects of the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9,-dien-28-oic acid methyl ester (CDDO-Me). Nanomolar CDDO-Me significantly enhanced antioxidative heme oxygenase-1 (HO-1) levels in NHEK only and not in the OSCC cell line, as shown by immunoblotting. In the presence of CDDO-Me reactive oxygen species (ROS) were found to be reduced in NHEK when applying radiation doses of 8 Gy, whereas ROS levels in OSCC cells rose significantly even without radiation. In parallel, CDDO-Me was shown to enhance metabolic activity in malignant cells only as indicated by significant accumulation of reducing equivalents NADPH/NADH. Clonogenic survival was left unchanged by CDDO-Me treatment in NHEK but revealed to be abolished almost completely in OSCC cells. The latter effect was confirmed by a CDDO-Me induced significant reduction of OSCC tumor xenograft-growth in-ovo applying the chick chorioallantoic membrane (CAM) assay. Our results strongly indicate anti-cancer and radio-sensitizing effects of CDDO-Me treatment in OSCC cells, whereas nanomolar CDDO-Me failed to provoke clear detrimental consequences in non-malignant keratinocytes. We conclude, that the observed differential aftermath of CDDO-Me treatment in malignant OSCC and non-malignant skin cells may be capitalized to broaden the therapeutic range of clinical RT.