bluuebunny/crossref_metadata_2025_split huggingface dataset:
MiR-200c/FUT4 axis prevents the proliferation of colon cancer cells by downregulating the Wnt/β-catenin pathway
Authors: Cong Jinchun , Yang Chuanjia , Xia Zhixiu , Gong Jian , Zhang Hong 
Published: December 2020

Abstract
Background: MicroRNA(miR)-200c has been widely reported to be involved in colon cancer progress. However, the mechanisms of miR-200c in regulating tumor metastasis and growth remain to be fully elucidated. This study aimed to investigate the mechanism of miR-200c targets fucosyltransferase 4 (FUT4) on the proliferation of colon cancer. Methods: The miR-200c and FUT4 mRNA levels in LoVo and SW480 cells were measured by real-time quantitative polymerase chain reaction. Further, miR-200c mimic, FUT4 siRNA and FUT4 mimic were transfected into cells, separately. Cell counting kit-8, plate colony formation and transwell assays were used to analyse the cells biological behaviour.. Immunofluorescence was used to analyse the Ki-67 expression Moreover, the Wnt/β-catenin pathway-related proteins were detected by western blots. A double luciferase experiment was performed to confirm the relationship between miR-200c and FUT4. In vivo , tumour growth and Wnt/β-catenin pathway-related proteins were also analysed. Results: In vitro, the expression of miR-200c and FUT4 were negatively correlated in LoVo and SW480 cells (correlation coefficients were -0.9046 and -0.9236, respectively). MiR-200c overexpression inhibited the proliferation, migration and invasion of LoVo and SW480 cells by downregulating FUT4. The Ki67-positive cells and Wnt/β-catenin signalling pathway-related proteins were reduced in the miR-200c overexpression and FUT4 silencing groups. A dual luciferase reporting system identified FUT4 as the target of miR-200c. The results in vivo were further confirmed the foundation of cells study. Conclusions: In summary, miR-200c overexpression inhibits proliferation of colon cancer targeting FUT4 to downregulate the Wnt/β-catenin pathway, which promises molecular targets to inhibit metastasis for colon cancer therapy.
A feasibility study of uninhabited aircraft systems for rapid and cost-effective plant stress monitoring at green stormwater infrastructure facilities
Authors: Prettyman Kery , Babbar-Sebens Meghna , Parrish Christopher E. , Babbar-Sebens Jeremy Matthew 
Published: December 2020

Abstract
Vegetation health monitoring is key to identifying early signs of water stress, pollutant-induced toxicity, and plant diseases in green urban stormwater facilities. However, rigorous monitoring to collect accurate quantitative data is an expensive and time-consuming process. This paper examines the feasibility of using uninhabited aircraft systems (UAS), in comparison to standard ground-based methods, for monitoring biomass and primary production in two bioswale cells at an urban stormwater facility. Implementation of the UAS-based approach involved flight planning in an urban area to meet resolution requirements of bioswale imagery obtained from near-infrared and red-green-blue cameras. The resulting normalized difference vegetation index (NDVI) estimated from UAS data was tracked over a 2-month period during the transition from spring to summer, showing the spatial distribution of NDVI and the change in vegetation coverage areas over time. In comparison, ground-based measurements of the fraction of intercepted photosynthetically active radiation (PAR) presented multiple practical challenges during implementation in the field, leading to over- and underestimates of intercepted PAR. Overall, UAS-derived NDVI was found to be a valuable reflectance-based, vegetation health-monitoring methodology that can be used by utilities and cities for practical, cost-effective, and rapid assessment of vegetation stress and for long-term maintenance in green stormwater facilities.
Intravitreal Dexamethasone Implant versus Intravitreal Ranibizumab Injection for Treatment of Non-Proliferative Diabetic Macular Edema: A Prospective, Randomized and Blinded Trial
Authors: Mishra Sanjay Kumar , Sinha Shruti , Chauhan Ravi , Kumar Ashok 
Published: December 2020

Introduction:
In the working age population, Diabetic Macular Edema (DME) is the
most common cause of visual loss.

Purpose:
The present study is aimed to assess the safety and efficacy of intravitreal injection of
Ranibizumab (IVR) versus intravitreal Dexamethasone implant (IVD) in patients with DME in a
tertiary care centre upto 4 months.

Methods:
This is a comparative, prospective, randomized study that was done on 140 patients with
macular edema confirmed on optical coherence tomography (OCT). IVD group received Ozurdex®
(Allergan, Inc, Ireland) while the IVR group received Lucentis® (Novartis, Basel, Switzerland); the
groups were followed up at day-1 and weeks 4, 8, 12, 16. Patients were divided into Group A, in
which patients were given 3 doses (monthly) of IVR 0.3 mg in 0.05 ml (n=70). Group B patients
were given a single dose of IVD implant 0.7 mg (n=70).

Results:
The mean number of injections given was 1 Ozurdex® per patient vs. 3 Lucentis® per patient.
The maximum reduction in central macular thickness (CMT) with IVD was 167.8 μm and
138.8μm in the 2nd and 3rd months, respectively, with IVR. The mean best-corrected visual acuity
(BCVA) in the 4th month was 0.34 logMAR and 0.33 logMAR, in IVD and IVR groups, respectively,
with consistent improvement. Patients with 0-5 letters, 6-10 letters and 10-15 letters, and >15
letters visibility in IVD group were 9.5, 20.6, 4.8, 6.4%, and 20.4, 18.8, 20.3 20.3% in IVR groups,
respectively. The maximum intraocular pressure (IOP) rise with IVD was found to be 16 mmHg in
2 patients (3.17%). IOP rise >10 mmHg was observed in 14/63 patients (22.22%); the majority of
patients indicated a high rise at 2nd month with all returning to baseline by 4th month. No reports of
infectious endophthalmitis or new cataracts were detected in either of the treated groups.

Conclusion:
Both intravitreal Ranibizumab injection and Dexamethasone implants were found to
be safe and effective in lowering CMT and improving BCVA at the 4-month follow up in patients
with DME. Since there was no recurrence of CMT in the Dexamethasone implant group, we
suggest that early administration before the 4th month may indicate superior efficacy over the
ranibizumab injection. Further randomized trials in a large sample size with a longer period follow-
up would be performed to justify the obtained results in the present study.
The Effects of Downloading a Government-Issued COVID-19 Contact Tracing App on Psychological Distress During the Pandemic Among Employed Adults: Prospective Study
Authors: Kawakami Norito , Sasaki Natsu , Kuroda Reiko , Tsuno Kanami , Imamura Kotaro 
Published: December 2020

Background
Downloading a COVID-19 contact tracing app may be effective in reducing users’ worry about COVID-19 and psychological distress.

Objective
This 2.5-month prospective study aimed to investigate the association of downloading a COVID-19 contact tracing app, the COVID-19 Contact Confirming Application (COCOA), released by the Japanese government, with worry about COVID-19 and psychological distress in a sample of employed adults in Japan.

Methods
A total of 996 full-time employed respondents to an online survey conducted May 22-26, 2020 (baseline), were invited to participate in a follow-up survey August 7-12, 2020 (follow-up). A high level of worrying about COVID-19 and high psychological distress were defined by baseline and follow-up scores on a single-item scale and the Kessler 6 (K6) scale, respectively. The app was released between the two surveys, on June 17. Participants were asked at follow-up if they downloaded the app.

Results
A total of 902 (90.6%) of 996 baseline participants responded to the follow-up survey. Among them, 184 (20.4%) reported that they downloaded the app. Downloading of the contact tracing app was significantly negatively associated with psychological distress at follow-up after controlling for baseline variables, but not with worry about COVID-19.

Conclusions
This study provides the first evidence that using a government-issued COVID-19 contact tracing app may be beneficial for the mental health of employed adults during the COVID-19 pandemic.
Clinical Advice by Voice Assistants on Postpartum Depression: Cross-Sectional Investigation Using Apple Siri, Amazon Alexa, Google Assistant, and Microsoft Cortana
Authors: Yang Samuel , Lee Jennifer , Sezgin Emre , Bridge Jeffrey , Lin Simon 
Published: December 2020

Background
A voice assistant (VA) is inanimate audio-interfaced software augmented with artificial intelligence, capable of 2-way dialogue, and increasingly used to access health care advice. Postpartum depression (PPD) is a common perinatal mood disorder with an annual estimated cost of $14.2 billion. Only a small percentage of PPD patients seek care due to lack of screening and insufficient knowledge of the disease, and this is, therefore, a prime candidate for a VA-based digital health intervention.

Objective
In order to understand the capability of VAs, our aim was to assess VA responses to PPD questions in terms of accuracy, verbal response, and clinically appropriate advice given.

Methods
This cross-sectional study examined four VAs (Apple Siri, Amazon Alexa, Google Assistant, and Microsoft Cortana) installed on two mobile devices in early 2020. We posed 14 questions to each VA that were retrieved from the American College of Obstetricians and Gynecologists (ACOG) patient-focused Frequently Asked Questions (FAQ) on PPD. We scored the VA responses according to accuracy of speech recognition, presence of a verbal response, and clinically appropriate advice in accordance with ACOG FAQ, which were assessed by two board-certified physicians.

Results
Accurate recognition of the query ranged from 79% to 100%. Verbal response ranged from 36% to 79%. If no verbal response was given, queries were treated like a web search between 33% and 89% of the time. Clinically appropriate advice given by VA ranged from 14% to 29%. We compared the category proportions using the Fisher exact test. No single VA statistically outperformed other VAs in the three performance categories. Additional observations showed that two VAs (Google Assistant and Microsoft Cortana) included advertisements in their responses.

Conclusions
While the best performing VA gave clinically appropriate advice to 29% of the PPD questions, all four VAs taken together achieved 64% clinically appropriate advice. All four VAs performed well in accurately recognizing a PPD query, but no VA achieved even a 30% threshold for providing clinically appropriate PPD information. Technology companies and clinical organizations should partner to improve guidance, screen patients for mental health disorders, and educate patients on potential treatment.
PENILAIAN MAKRO ARSIP: DASAR HUKUM, METODE DAN IMPLEMENTASINYA
Authors: Agniya Ursa , Mayesti Nina 
Published: December 2020

Penilaian arsip merupakan salah satu kegiatan utama dalam sistem pengelolaan arsip. Meski tidak dijelaskan secara langsung, penilaian arsip di Indonesia dilakukan dalam rangka melakukan kegiatan penyusutan arsip, maka dari itu dalam melakukan penilaian arsip haruslah berpedoman pada undang-undangan yang berlaku. Penilaian makro arsip merupakan penilaian yang bersifat top-down dimana arsiparis atau pengelola arsip tidak lagi menilai arsip sebagai sebuah akhir dari proses kegiatan organisasi atau bottom-up. Penilaian makro merupakan sebuah pendekatan untuk penilaian arsip dan membahas mengenai teknik penilaian dan penilaian makro pada tingkat teoritis yang tujuan utamanya bukan wacana teoritis tetapi lebih ke eksplorasi metodologi. Dalam implementasinya, arsiparis banyak yang menerapkan metodologi penilaian makro namun kebanyakan melakukan modifikasi dalam penerapan yang sebenarnya. Singkatnya, sebagian kecil arsiparis arsip publik telah secara sadar dan berhasil menerapkan pendekatan ini secara teoritis konsisten. Terlepas dari hasil untuk saat ini, karakter implementasi penilaian makro menimbulkan pertanyaan apakah teori penilaian makro dengan sendirinya merupakan dasar yang kuat untuk standardisasi.
Prospective Cohort Study of Renin-Angiotensin System Blocker Usage after Hospitalized Acute Kidney Injury
Authors: Brar Sandeep , Liu Kathleen D. , Go Alan S. , Hsu Raymond K. , Chinchilli Vernon M. , Coca Steven G. , Garg Amit X. , Himmelfarb Jonathan , Ikizler T. Alp , Kaufman James , Kimmel Paul L. , Parikh Chirag R. , Siew Edward D. , Ware Lorraine B. , Zeng Hui , Hsu Chi-yuan ,   for the ASsessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) study investigators
Published: December 2020

Background and objectives
The risk-benefit ratio of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker therapy after AKI may be altered due to concerns regarding recurrent AKI. We evaluated, in a prospective cohort, the association between use (versus nonuse) of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers and the subsequent risk of AKI and other adverse outcomes after hospitalizations with and without AKI.

Design, setting, participants, & measurements
We studied 1538 patients recently discharged from the hospital who enrolled in the multicenter, prospective ASSESS-AKI study, with approximately half of patients experiencing AKI during the index hospitalization. All participants were seen at a baseline visit 3 months after their index hospitalization and were categorized at that time on whether they were using angiotensin-converting enzyme inhibitors/angiotensin receptor blockers or not. We used multivariable Cox regression, adjusting for demographics, comorbidities, eGFR, urine protein-creatinine ratio, and use of other medications, to examine the association between angiotensin-converting enzyme inhibitor/angiotensin receptor blocker use and subsequent risks of AKI, death, kidney disease progression, and adjudicated heart-failure events.

Results
The use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers was 50% (386/769) among those with AKI during the index hospitalization and 47% (362/769) among those without. Among those with AKI during the index hospitalization, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker use was not associated with a higher risk of recurrent hospitalized AKI (adjusted hazard ratio, 0.88; 95% confidence interval, 0.69 to 1.13). Associations between angiotensin-converting enzyme inhibitor/angiotensin receptor blocker use and death, kidney disease progression, and adjudicated heart-failure events appeared similar in study participants who did and did not experience AKI during the index hospitalization (all interaction P values >0.05).

Conclusions
The risk-benefit ratio of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker therapy after hospital discharge appears to be similar regardless of whether AKI occurred during the hospitalization.
Remote Patient Healthcare surveillance system based real-time vital signs
Authors: Alsahi Qunoot N. , Marhoon Ali F. , Hamad Ali H. 
Published: December 2020

Today many people suffering from health problems like dysfunction in lungs and cardiac. These problems often require surveillance and follow up to save a patient's health, besides control diseases before progression. For that, this work has been proposed to design and developed a remote patient surveillance system, which deals with 4 medical signs (temperature, SPO2, heart rate, and Electrocardiogram ECG. An adaptive filter has been used to remove any noise from the signal, also, a simple and fast search algorithm has been designed to find the features of ECG signal such as Q,R,S, and T waves. The system performs analysis for medical signs that are used to detected abnormal values. Besides, it sends data to the Base-Station with a data block (ECG signals) that contains the problem. In addition, it generates an alarm to the physicians via ringing up mobile and SMS to overcome the internet disconnected. Also, the system has been designed to achieve precision, low cost, and low energy consumption. Three types of sensors has been used in this work, ECG, SPo2, and temperature sensors. Also, a sim800L GSM module has been used for communications, the main controller in this work is ESP32 unit.
ASSESSMENT ON IMPACT OF COVID 19 PANDEMIC ON FEAR AND SOCIOECONOMIC STATUS AMONG SOUTH INDIAN POPULATION
Authors: NYAYAKAR SREEJA , M. MUTHUKUMAR , MOOTHI LATHA SREE 
Published: December 2020

Objective: To assess the impact of the COVID 19 pandemic on fear and socioeconomic status among the south Indian population.
Methods: A prospective observational cross-sectional study was conducted on 18-year old and older people who are willing to fill the online form were included in the study. People who are not willing to fill the form and those who filled the forms incompletely were excluded from the study. Microsoft Excel was used for recording and analyzing the data of recruited subjects. Descriptive statistical analyses were used to calculate the average and standard deviation.
Results: In total 476 respondents were included in the study to make the results. From the 476 respondents, 53.9% were males and 43.4% were females, 43.4% of individuals were satisfied with family life, 31.7% of individuals were satisfied with their salary, 37.3% of individuals were satisfied with their economic position, 55.2% of individuals were satisfied with their health and 50.4% of individuals were satisfied with their life in general.
Conclusion: Our study concludes that young students are showing more interest in online surveys among other general populations and data concludes that fear about the infection was less among the study population. More than half of the participants are concerned about their salary and most of the participants are not feared about their family life and their health.
CONSTRUÇÃO DE NOVO MODELO DE MAPA INTELIGENTE COMO INSTRUMENTO DE TERRITORIALIZAÇÃO NA ATENÇÃO PRIMÁRIA
Authors: Budal Aline Mitie Both , Mazza Verônica Azevedo , Buffon Marilene da Cruz Magalhães , Ditterich Rafael Gomes , Jocowski Michele , Plucheg Valquiria 
Published: December 2020

A respeito da territorialização na atenção primária à saúde, o presente estudo é um relato de experiência que objetiva descrever a construção de um novo modelo de mapa inteligente em uma unidade de saúde da família no município de Colombo (PR). Para a construção dos mapas foram utilizados softwares de imagem por satélite e de desenho digital. Os mapas foram confeccionados por microárea, impressos e entregues aos agentes comunitários de saúde que, durante visitas domiciliares, inseriram as informações do território. Por serem embasados em fotos por satélite, os mapas representam o território de forma realista e dinâmica, além de ter como características a facilidade em seu manuseio, pois podem ser levados a campo, e ser de fácil preenchimento de informações e compreensão. O mapa inteligente, como instrumento de uso individual do agente comunitário de saúde e de uso coletivo da equipe, se torna ferramenta importante na identificação das situações de saúde do território e no planejamento, execução e acompanhamento das atividades na comunidade. A aproximação do espaço de vivência das pessoas com a equipe de saúde por meio de mapas inteligentes no cotidiano dos serviços permite maior reconhecimento do território e maior vinculação da unidade básica de saúde à população.
Palavras-chave: Territorialização. Saúde pública. Planejamento em saúde. Atenção primária à saúde.
EDUCAÇÃO POPULAR EM SAÚDE: RELATO DE EXPERIÊNCIAS DA PRÁTICA DE RESIDENTES DE UNIVERSIDADES PÚBLICAS PARAENSES
Authors: Afonso Amanda de Queiroz , Araújo Ila Iandara de Souza , Santos Lays Ariane Teixeira dos , Macambira Lais Helena Rescinho , Santos Sarah Manuele Cuimar dos , Galvão Sâmela Stefane Corrêa 
Published: December 2020

A educação popular em saúde prioriza o diálogo aberto sobre problemas de saúde com os atores sociais, respeitando suas culturas, reconhecendo-as como válidas e promovendo análise crítica de tal modo que os empodere como reais cidadãos. Este trabalho objetiva relatar as experiências com educação popular em saúde de residentes de universidades públicas paraenses a fim de os apresentar como caminho capaz de colaborar com saberes, tecnologias e metodologias para a construção de novas práticas no âmbito do Sistema Único de Saúde. Criou-se, assim, grupo de grávidas em Unidade de Saúde da Família no município de Ananindeua, Pará. Trata-se de relato de experiência dos residentes de Saúde da Família com grupo de gestantes, utilizando conceitos e ferramentas da educação popular, de março de 2015 a julho de 2016. Por meio de reuniões periódicas entre a equipe, elaborou-se cronograma, palestras educativas e fôlderes com informações relativas à gestação. As gestantes encontravam-se na faixa etária de 15 a 35 anos, em sua maioria multíparas, com baixo nível de escolaridade, renda familiar mensal de um salário mínimo e sem emprego formal. Nota-se que, por estarem inseridas em contexto cultural amazônico, o conhecimento empírico norteia as práticas de seu cotidiano. Metodologias ativas de educação permitem o diálogo, a troca de experiências, além de valorizar a gestante como parte importante e principal no processo de mudança de sua realidade. Apesar das barreiras encontradas para a manutenção do grupo, observou-se colaboração das gestantes nas reuniões, interação e fortalecimento da relação profissional-usuário.
Palavras-chave: Educação em saúde. Internato. Residência. Gestantes.
MORTALIDADE POR CÂNCER DO COLO DO ÚTERO NO ESTADO DA BAHIA, BRASIL, ENTRE 1996 E 2012
Authors: Cruz Naiana Manuela Rocha Arcanjo da , Cruz Karlos Eduardo Arcanjo da , Silva Carlos Alberto Lima da 
Published: December 2020

O câncer de colo do útero ainda é um problema de saúde pública no Brasil, sendo a quarta causa de morte por câncer na população feminina apesar dos mais altos potenciais de prevenção e cura entre todos os tipos de câncer. O objetivo deste estudo é analisar a tendência da mortalidade por câncer cervical na Bahia entre 1996 e 2012. Realizou-se um estudo ecológico que investigou os óbitos por câncer do colo do útero de mulheres residentes no estado, com idade igual ou superior a 20 anos, entre 1996 e 2012. Como fonte de dados, utilizou-se o Datasus. Foram calculadas taxas de mortalidade específicas por idade, por macrorregião de saúde, brutas e padronizadas pela população mundial. A análise de tendência foi realizada por modelos de regressão linear. Calculou- -se a variação percentual, a percentagem por estado civil e local de ocorrência do óbito. A Bahia apresentou 6.275 mortes por câncer de colo do útero, com taxa de mortalidade média de 6/100.000 mulheres, sendo observada tendência de estabilidade entre 1996 e 2012. O risco de morte cresceu com o aumento da idade. A macrorregião de saúde com maior taxa de mortalidade foi a Leste, porém apresentou tendência decrescente. Do total de óbitos, a maioria foi de mulheres solteiras (46,4%), e 69,3% das mortes ocorreram no hospital. Na Bahia, a mortalidade por câncer de colo do útero ainda é elevada, o que sugere a necessidade de implementação de estratégias específicas para o enfrentamento da morbimortalidade por este agravo.
Palavras-chave: Neoplasias do colo do útero. Saúde da mulher. Mortalidade.