bluuebunny/crossref_metadata_2025_split huggingface dataset:
Levels of Retinal Amyloid-β Correlate with Levels of Retinal IAPP and Hippocampal Amyloid-β in Neuropathologically Evaluated Individuals
Authors: Schultz Nina , Byman Elin ,   the Netherlands Brain Bank, Wennström Malin 
Published: December 2019

Background: Previous studies have used immunohistology to demonstrate Alzheimer’s disease (AD) characteristic accumulation of amyloid-β (Aβ) in the retina of AD patients, a finding indicating retina examination as a potential diagnostic tool for AD pathology. Objective: To further explore this idea by investigating whether levels of Aβ42 and Aβ40 in retina are associated with corresponding levels in hippocampus, neuropathological assessments, apolipoprotein E ( APOE) genotype, and levels of islet amyloid polypeptide (IAPP). Methods: Levels of high molecular weight (HMW) Aβ42, Aβ40, and IAPP in ultra-centrifuged homogenates of retina and hippocampus from patients with AD, multiple sclerosis, AD with Lewy bodies, and non-demented controls were analyzed using Mesoscale Discovery electrochemiluminescence technology employing immunoassay and enzyme-linked immunosorbent assay. Results: Higher levels of retinal and hippocampal Aβ42- HMW, Aβ40-HMW, and IAPP-HMW were found in individuals with high neuropathological scores of Aβ plaques and in individuals carrying the APOE ɛ4 allele. The retinal levels of Aβ42- HMW and Aβ40-HMW correlated with corresponding levels in hippocampus as well as with neurofibrillary tangles (NFT) and Aβ scores. Retinal IAPP-HMW correlated with retinal levels of Aβ42- HMW and with NFT and Aβ scores. Conclusion: These results show that different isoforms of Aβ can be detected in the human retina and moreover support the growing number of studies indicating that AD-related pathological changes occurring in the brain could be reflected in the retina.
Neuropsychiatric Correlates of Small Vessel Disease Progression in Incident Cognitive Decline: Independent and Interactive Effects
Authors: Kan Cheuk Ni , Gyanwali Bibek , Hilal Saima , Ng Kok Pin , Venketasubramanian Narayanaswamy , Chen Christopher Li-Hsian , Xu Xin 
Published: December 2019

Background: Cerebral small vessel disease (SVD) and neuropsychiatric symptoms (NPS) independently increase the risk of cognitive decline. While their co-existence has been reported in the preclinical stage of dementia, longitudinal data establishing the prognosis of their associations, especially in an Asian context remains limited. Objective: This study investigated the role of SVD and NPS progressions on cognitive outcomes over 2 years in a dementia-free elderly cohort. Methods: 170 dementia-free elderly with baseline and 2-year neuropsychological assessments and MRI scans were included in this study. White matter hyperintensities (WMH), lacunes, and microbleeds (CMBs) were graded as markers of SVD. The Neuropsychiatric Inventory (NPI) was used to measure NPS. Generalized estimating equations modelling evaluated the relationship between NPI change and SVD progression. Logistic regression evaluated the risk of incident cognitive decline with both SVD and NPS. All models were adjusted for demographics, baseline cerebrovascular diease, and medial temporal lobe atrophy. Results: Higher NPI scores were associated with higher SVD burden at baseline. Subjects with WMH progression had greater increase in total NPI (β[SE] = 0.46[0.19], p = 0.016), driven by hyperactivity subsyndrome (β[SE] = 0.88[0.34], p = 0.007). Subjects with incident CMBs had greater increase in psychosis subsyndrome (β[SE] = 0.89[0.30], p < 0.001). Subjects with progressions in both SVD and NPS were more likely to develop cognitive decline over 2 years (OR[95% CI] = 4.17[1.06–16.40], p < 0.05). Conclusion: Our findings support worsening of NPS as a clinical indicator of SVD progression and are associated with cognitive decline over 2 years. Early detection of NPS and targeted interventions on SVD burden may improve NPS outcomes.
Strategi Bimbingan Guru Strategi Bimbingan Guru Untuk Mengungkap Kemampuan Literasi dan Karakter Siswa Menyongsong Abad 21
Authors: Huzaemah Siti 
Published: December 2019

Tulisan ini bertujuan menguraikan strategi bimbingan penulis mengungkap kemampuan literasi dan karakter siswa pada pokok bahasan perkembangbiakan pada makhluk hidup, sebagai upaya membekali keterampilan hidup menyongsong abad 21. Untuk mengungkap kemampuan literasi, siswa diminta membuat laporan individu kegiatan praktik mencangkok berbentuk cerita, dengan tahap-tahap tulis, nilai, revisi, ketik, kirim dan edit. Untuk mengungkap karakter siswa, salah satu aspek yang harus dituliskan siswa dalam laporannya adalah kinerja masing-masing anggota dalam kelompoknya. Metode penelitiannya kualitatif dengan subjek penelitian kelas IX G SMPN 1 Baros Tahun Pelajaran 2018/2019. Instrumen penelitian berupa rubrik penilaian teks laporan, lembar tabulasi karakter yang ditampilkan siswa pada karakter dapat bekerja sama, bertanggung jawab, dan peduli lingkungan, serta lembar penilaian sikap sosial antar teman. Hasil analisis data menunjukkan sebagian siswa yaitu 16 orang atau 52 % sudah menunjukkan kemampuan literasi sesuai ketentuan guru, sedangkan 15 siswa atau 48 % masih kurang bisa. Dillihat dari karakter yang diamati, siswa sudah memiliki karakter bertanggung jawab kategori baik dengan total skor 85, dan juga memiliki karakter mampu bekerjasama kategori baik dengn total skor 89. Namun untuk karakter peduli lingkungan hanya ada pada skor 46 atau kategori sangat kurang. Maka dapat disimpulkan strategi bimbingan guru yang meliputi tahap tulis, nilai, revisi, ketik, kirim dan edit dapat mengungkap kemampuan literasi dan seta menilai karakter siswa secara lebih objektif pada pokok bahasan perkembangbiakan pada makhluk hidup sebagai bekal menyongsong hidup pada Abad 21.
Kata Kunci. Strategi Bimbingan Guru, Literasi, Karakter, Abad 21
Systemic Evaluation of the Threats to the Strategy of Technological Development of Russia
Authors: Nikonova A. A. 
Published: December 2019

The article is devoted to the study of factors that inhibit the creation of knowledge and technologies, as well as usage and diffusion in the Russian economy and that pose the threats to the technological development of the country. The study is based on the system economic theory methodology, which involve system analysis methods studying the economy and society as an integrated socio-economic system in its unity and mutual dependence of key subsystems. This approach is aimed to receive evaluation reflecting the real static and dynamic picture of all sectors that contribute to the creation of innovation: production, monetary systems, institutional environment, science, education and society. The risk zones are depicted in the diagram of the strategic planning and governance inherent Russian practice. From a systemic point of view, the conclusions are that the objective system evaluation should be in the basis of the strategy. Inadequate quality of planning, ignoring system linkages and interactions in decision-making, use of incorrect data as well as other defective governance actions pose a significant threat to the development of the Russian Federation. The directions for further research in order to reduce the risks of technological development strategy are proposed in the paper. The proposals concern improvement in both evaluation methods and the metrics of the socio-economic system characteristics, which can give the truth picture of the system, and the concept of strategizing changes in non-stationary economy.The author declare no conflict of interest.
Strategic Risks of the Public Administration in the Digital Economy
Authors: Smotritskaya I. I. , Chernykh S. I. , Shuvalov S. S. 
Published: December 2019

The current decade is a period of origination and manifestation of the game-changing strategic challenges and threats as well as the geopolitical, socio-economic, institutional, and technological risks that arise from the development and penetration of the digital technologies. The World economy is entering the new stage of its development that implies that the human production, exchange, distribution, and consumption activities are directly connected with the formation, processing, and application of large amounts of information and knowledge that exist in a digital format. The concepts "The digital economy" and "The knowledge-based economy" are becoming inseparable and this has an impact on the digital transformation of the institutions of public administration. The digital technologies are increasing the capabilities of the State to respond the global challenges but at the same time generating the new strategic risks, especially institutional and technological ones. Furthermore, the possible directions of the digital evolution of the State are still discussing, not defined. The paper deals with the concept of the digital transformation of the institutions of the public administration with the risks being taken into account. Conclusion that optimizing the above strategic risks is a critical national priority.The authors declare no conflict of interest.
NCTM’s Principles and Standards for Developing Conceptual Understanding in Mathematics
Authors: Saleh Haji  
Published: December 2019

The purpose of this study is to develop understanding of concepts in mathematics through the application of the NCTM's Principles and Standards. This research method is descriptive. The results obtained are understanding concepts in mathematics can be developed through the application of NCTM Principles and Standards consisting of 6 principles, namely: 1. Equity, 2. Curriculum, 3. Teaching, 4. Learning, 5. Assessment, and Technology. Understanding concepts in mathematics that can be developed are: a. defining concepts verbally and in writing, b. Make examples and not examples, c. Using various symbols to present a concept, d. Change the form of representation to various forms, e. Identifying the characteristics of a concept, f. compare various concepts, and g. interpret concepts.
Faktor Penyebab Terjadinya Interferensi Sintaksis Bahasa Angkola dalam Bahasa Indonesia Tulis pada Peserta Didik di Tk Aisyah Bustanul Athfal 3 Padangsidimpuan
Authors: Anni Rahimah  , Mina Syanti Lubis  , Ilham Sahdi Lubis  
Published: December 2019

Penelitian ini membahas tentang faktor penyebab terjadinya interferensi sintaksis Bahasa Angkola dalam Bahasa Indonesia Tulis pada peserta didik di Tk Aisyah Bustanul Athfal 3 Padangsidimpuan. Tujuan penelitian ini adalah untuk mengetahui faktor penyebab terjadinya interferensi sintaksis Bahasa Angkola dalam Bahasa Indonesia Tulis pada peserta didik di Tk Aisyah Bustanul Athfal 3 Padangsidimpuan. Lokasi penelitian ini dilaksanakan di TK Aisyah Bustanul Athfal 3 Padangsidimpuan. Penelitian ini menggunakan jenis metode kualitatif. Berdasarkan hasil analisis data pada penelitian ini maka ditemukan dua faktor penyebab terjadinya interferensi bahasa yaitu faktor kebahasaan dan faktor non-kebahasaan. Hal tersebut terjadi karena pengaruh bahasa yang lebih dulu dikuasainya, ketidak pahaman peserta didik sebagai pemakai bahasa terhadap bahasa yang dipakainya, pengajaran bahasa yang kurang sempurna atau kurang tepat dan pengaruh lingkungan sekitar yang memakai dwi bahasa maka berpengaruh kepada interferensi pemakainya.

This research discusses the causal factors in the syntactic interference of Bahasa Angkola towards Indonesian Writing to the students’ in TK Aisyah Bustanul Athfal 3 Padangsidimpuan. The purpose of this research is to find out the causal factors in the syntactic interference of Bahasa Angkola towards Indonesian Writing to the students’ in TK Aisyah Bustanul Athfal 3 Padangsidimpuan. The location of this research was carried out in TK Aisyah Bustanul Athfal 3 Padangsidimpuan. This research uses a qualitative research methods. Based on the results of data analysis in this research, two factors were found to cause language interference, namely linguistic factors and non-linguistic factors. This happens because of the influence of the language that was mastered first, the understanding of students as users of language towards the language they use, imperfect language teaching or inaccurate and the influence of the surrounding environment using the bilingual language will affect the wearer's interference.
Kesalahan-Kesalahan yang Dilakukan oleh Mahasiswa Semester Akhir Program Studi Bahasa Indonesia di Institut Pendidikan Tapanuli Selatan dalam Penulisan Karya Tulis Ilmiah (KTI)
Authors: Mina Syanti Lubis  , Anni Rahimah  , Ilham Sahdi Lubis  
Published: December 2019

Penelitian ini mengidentifikasi masalah yang membatasi penggunaan sampel populasi data hanya pada mahasiswa yang mengampuh mata kuliah bahasa Indonesia di Program Studi Bahasa Indonesia IPTS. Dengan adanya beberapa identifikasi masalah, maka peneliti terfokus pada masalah yang diteliti, yaitu tentang kesalahan- kesalahan apa sajakah yang dilakukan oleh mahasiswa yang mengampuh mata kuliah bahasa Indonesia di Program Studi Bahasa Indonesia IPTS dalam penulisan KTI. Tujuan penelitian ini adalah untuk mengidentifikasi kesalahan-kesalahan penulisan KTI yang dilakukan mahasiswa yang mengampuh mata kuliah bahasa Indonesia di Program Studi Bahasa Indonesia IPTS. Secara teoretis penelitian ini bermanfaat sebagai tuntunan untuk menghindari kesalahan-kesalahan yang sering terjadi pada saat penulisan KTI untuk mahasiswa khususnya dalam mata kuliah bahasa Indonesia di Program Studi Bahasa Indonesia IPTS. Temuan dalam penelitian ini menunjukkan beberapa kesalahan dalam penulisan KTI diantaranya adalah Kesalahan dalam menyusun struktur penulisan karya tulis ilmiah, Penulisan bagian abstrak, Isi terlalu panjang dengan pendahuluan yang berlebihan, Kesalahan dalam cara mengutip pendapat orang lain sehingga berkesan menjiplak (plagiat), Penggunaan bahasa Indonesia yang belum baik dan benar (penggunaan spasi pada penulisan tanda baca dan penulisan imbuhan di-, ke-, kata di), Tidak konsisten dalam format tampilan (font yang berubah-ubah, margin yang berubah-ubah), Penulisan kata berbahasa asing.

This study discusses the problem that discusses the use of data samples only for students who apply Indonesian language courses in the Indonesian Language Studies Program at IPTS. By presenting several problems, this study focuses on the issues discussed, namely what the problems are made by students who apply Indonesian Language courses in the IPTS Indonesian Language Study Program in accessing scientific writing. The purpose of this study is to correct the mistakes made by scientific writing by students who apply Indonesian language courses in the Indonesian Language Studies Program at IPTS. Theoretically, this study is useful to solve mistakes that often occur when discussing scientific writing for students specialized in Indonesian language courses in the Indonesian Language Studies Program at IPTS. The findings in this study indicate that several errors in the scientific writing discussion were published: the errors in the composition of scientific papers, writing abstract sections, content too long with excessive introduction, the errors in how to quote other people's opinions can be plagiarized (plagiarism), the use of Indonesian that is not good and right (use spaces in punctuation changes and additions in, words, di), inconsistent in display format (fonts change, margins change), writing foreign pronouns.
Analisis Tindak Tutur Langsung Tidak Literal Guru Terhadap Siswa Yang Berkebutuhan Khusus dalam Proses Belajar Mengajar Di Slb-Ab Bukesra Ulee Kareng Banda Aceh
Authors: Sri wahyuni  , Hijratul Aini  , Widika Agnesia  
Published: December 2019

Kajian ini menganalisis tindak tutur guru dalam proses belajar mengajar pada siswa yang berkebutuhan khusus di sekolah luar biasa. Guru berperan penting dalam melakukan tindak tutur di sekolah, hal ini disebabkan karena sering terdengarnya keluhan guru terhadap kurangnya respons siswa berkebutuhan khusus dalam pembelajaran. Peneliti melakukan penelitian ini untuk mengetahui jenis tindak tutur yang digunakan guru di sekolah luar biasa tersebut. Tujuan penelitian ini adalah untuk mendeskripsikan bentuk tindak tutur langsung guru terhadap siswa yang berkebutuhan khusus dalam proses belajar mengajar di SLB-AB Bukesra Ulee Kareng Banda Aceh. Data penelitian ini adalah tindak tutur langsung guru terhadap siswa yang berkebutuhan khusus dalam proses belajar mengajar di SLB-AB Bukesra Ulee Kareng Banda Aceh. Data dikumpulkan dengan metode kualitatif dengan teknik rekam, catat, dan wawancara. Hasil penelitian ini menyimpulkan tindak tutur langsung tidak literal guru terhadap siswa yang berkebutuhan khusus dalam proses belajar mengajar terdiri atas tindak tutur direktif dengan berbagai modus, di antaranya (1) modus memerintah, (2) modus bertanya, (3) modus memuji, dan (4) modus menasihati secara langsung. Hasil penelitian ini akan disubmit artikel jurnal nasional terakreditasi dan prosiding seminar nasional.

This study analize teacher's speech act in the process learning to the student's with special needs at the extraordinari school. The teacher has important role in the speeching acts at school, this is caused by frequent teacher's complaints lack of response student's with special needs in the learning. Researcher doing this research to know the type of speech act that used by the teacher at extraordinary school. the purpose of this study to describe the shape of teacher's direct speech to the student's with special needs in the learning at SLB-AB Bukesra Ulee Kareng Banda Aceh. This research is teacher's direct speech to the student's with special needs in the process learning at SLB-AB Bukesra Ulee Kareng Banda Aceh. Data is collected qualitative methods with recording techniques, notes, and interviews. the result of this research concluded the teacher's non literal direct speech act to the student's with special needs in the process learning consist of dirictive speech acts with various modes including (1) rule mode (2) ask mode (3) praise mode (4) direct advising mode. the result of this research will be submitted to accredited national journal articles and national seminar procesdings.
DESIGN INFORMATION SYSTEM STOCK INVENTORY TO MANAGE DATA OF GOODS (Case Study: PT Monier)
Authors: Supriyanti Dedeh , Kesumawati Christien Setiya , Maryam Siti 
Published: December 2019

Application of information system on the inventory will provide many benefits for the company in developing company in order to improve the company's performance become more effective and efficient. This research was conducted at manufacturing companies, to know overall about inventory items in the company. The purpose of this research is to find out the effectiveness of the inventory as a resource physical economy that needs to be held and maintained in order to support the process booking goods and sales in progress PT Monier. PT Monier is as a company manufacturers concrete roofing materials with the production system where the process for creating objects with cross-section of fixed. The methods of analysis used is descriptive data analysis method. Engineering data collection with do the observations to the company, conducting interviews, and route the study library with books, the literary, the materials gained during lectures relevant to the problems examined. Research results shows that the control of inventory items It often happens booking of the goods to the supplier in excess inventory and the shortage of supplies. Due to the lack of regard for the State of inventory items. Inventory data input errors often occur more than once for similar goods give rise to errors in reporting. Then the author here attempted to analyze the problems against information systems inventory items and to find solutions to the fore of the existing problems by fixing a system that is less than optimal.
Keywords : Information Systems, Effectiveness, Inventory Items
The Amelioration of Nutritional Status and Phase Angle, Safety, and Satisfaction in Tube-Fed Patients With Ready-to-Use Blenderized Diet With Chicken and Pumpkin
Authors: Jayanama Kulapong , Maitreejorn Piyanuch , Tangsermwong Thanwarin , Phanachat Pariya , Chattranukulchai Prapimporn , Tanlakit Patcharavee , Warodomwichit Daruneewan 
Published: December 2019

Background: The requirement of a hospital-made, blenderized diet, as a generally used and complete polymeric formula, is increasing beyond supply availability and accessibility. A ready-to-use blenderized diet with chicken and pumpkin in a retort pouch was developed from regular use formula by nutritionists and dietitians to solve these problems. However, its clinical outcomes should be evaluated.
Objectives: To assess the efficacy and safety of a ready-to-use blenderized diet, and to examine the satisfaction of patients and caregivers.
Methods: Thirty adult patients in Ramathibodi Hospital with absolute tube feeding were included in a pre-post treatment comparative study and fed with the study formula for 14 days. Body composition measurements, nutritional status, clinical parameters, and biochemical tests were collected at baseline and day 14 after feeding. Complications were monitored daily. Satisfaction was evaluated at day 14.
Results: This study reported statistically significant improvements in nutritional status (P < .001), albumin (P = .003), prealbumin (P = .007), total lymphocytic count (P = .004), and phase angle (P = .02) after 14-day feeding. No major complications were reported. Satisfaction of product use was evaluated in the level of satisfied (27%) and very satisfied (73%).
Conclusions: The present study revealed that a ready-to-use blenderized diet with chicken and pumpkin was efficacious in ameliorating nutritional status, nutrition-related blood tests, and phase angle without any major complications.
Isolation and characterization of aerial bacteria from a microbiology laboratory environment
Authors: AN Usman , Aliyu J , Christiana B , Umar U , Adedayo AI , David BJ , Adamu KF 
Published: December 2019

Sterile nutrient agar (NA) plates were exposed to the inner and outer environment of the laboratory for 15 minutes before the commencement of laboratory work in the morning and after closure of activities in the evening after which the plates were incubated at 37oC for 24 hours. Antibiotic susceptibility of the bacterial isolates was done using agar well diffusion technique. The aerial bacterial load outside the laboratory was found to be higher than inside the laboratory. Bacteria isolated include members of the genus Staphylococcus, Bacillus, Lactobacillus, Salmonella, Micrococcus, Streptococcus, Proteus and Escherichia. Bacillus subtilis had the highest frequency of occurrence (31.0%) followed by alpha haemolytic streptococcus (19.0%) while the least frequency of occurrence was shown by Proteus bulgaricus and Proteus species (1.7%). All the bacteria were sensitive to antibiotics tested except Micrococcus luteus. They were equally found to be sensitive to the anti-microbial agent (antiseptic and disinfectant) tested except for the hand sanitizer to which most isolates displayed high resistance. The presence of a wide variety of pathogenic microorganisms in the laboratory shows that the environment requires regular cleaning and disinfection to enhance the safety of staff and students using the laboratory.
J. bio-sci. 26: 41-48, 2018