bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Various Weights in the Intraoperative Skull-Skeletal Traction on Correction of Adolescent Idiopathic Scoliosis
Authors: Kato So , Lewis Stephen J. , Sharma Ohm , Chua Sooyong , Rabin Doron , Al-Jahwari Ahmed , Bacon Sarah , Gray Randolph J. , Keshen Sam , Magana Sofia , Zeller Reinhard D. 
Published: October 2019

Study Design: A retrospective study. Objectives: Intraoperative skull-skeletal traction (ISST) facilitates the surgical scoliosis correction, but it is also associated with neurological risk. The objective of the present study was to investigate the impact of various traction weights on neurophysiological change and curve correction in surgery for adolescent idiopathic scoliosis (AIS). Methods: A retrospective review of a consecutive series of posterior spinal fusions for AIS patients undergoing corrections with the use of ISST by 2 surgeons in one institution was performed. Intraoperative prone, post-traction radiographs were performed on all cases. The cases were divided into 2 groups, high and low traction weights, based on whether the weight used was ≥35% or <35% of body weight. The frequency of neurophysiological changes and the curve correction were compared between the 2 groups. Results: The intraoperative correction magnitudes by ISST were significantly larger in the high ISST group than in the low ISST group (35° vs 26°, P < .001). Changes in motor-evoked potential (MEP) were more frequently observed in the high ISST group (47% vs 26%, P = .049). A multivariate analysis showed that high ISST was associated with 3 times higher risk of MEP change (95% confidence interval = 1.1-8.0, P = .03) and higher final postoperative correction rates (68% vs 60%, P = .001). Conclusions: The high ISST for AIS was associated with increased intraoperative and ultimate curve corrections, and potentially facilitated better final correction. However, the high weight group was associated with an increased frequency of intraoperative MEP changes.
Is there an optimal timing of administration of single-dose intravenous tranexamic acid in bilateral total knee arthroplasty? A comparison between preoperative and intraoperative dose
Authors: Balachandar Gopalan , Abuzakuk Tarek 
Published: October 2019

Purpose: There is no consensus on the optimum timing of administration of tranexamic acid (TA) in bilateral total knee arthroplasty (TKA). We aimed to determine whether the timing of administration of single-dose intravenous TA (either given preoperatively or intraoperatively) has a significant effect on blood loss reduction. Methods: We compared two cohorts of patients with end-stage arthritis of knees who underwent bilateral TKA and were given single-dose intravenous TA (1 g or 15 mg/kg) at different times during surgery. The retrospective cohort group consisting of 40 patients (preoperative (PO) group) received TA before the skin incision. The prospective cohort consisting of 40 patients (intraoperative (IO) group) received TA 10 min before deflating the tourniquet on the first knee. Primary outcome measures were mean hemoglobin difference, A (between PO and day 1 postoperative hemoglobin), mean hemoglobin difference, B (between PO and lowest postoperative hemoglobin), and rate of allogeneic blood transfusion. Secondary measure was drain blood loss. Results: Both cohorts were well matched with respect to age, gender, duration of surgery, and length of hospital stay. The hemoglobin drop in the IO group was significantly lesser than the PO group on the first postoperative day (2 vs. 2.9 g/dL, p < 0.001). Although statistically insignificant, the patients in the IO group received less allogenic transfusion of packed cell units than in the PO group (11/40, 27.5% vs. 14/40, 35% ). Mean hemoglobin difference, B, and secondary drain loss were comparable in both groups. Conclusion: Single-dose intravenous TA given before the start of surgery is as effective as a dose given during arthroplasty of the first knee in reducing blood loss in bilateral TKA.
Return to Sports After Surgical Treatment of Osteochondral Defects of the Talus: A Systematic Review of 2347 Cases
Authors: Steman Jason A.H. , Dahmen Jari , Lambers Kaj T.A. , Kerkhoffs Gino M.M.J. 
Published: October 2019

Background: Osteochondral defects (OCDs) of the talus are found subsequent to ankle sprains and ankle fractures. With many surgical treatment strategies available, there is no clear evidence on return-to-sport (RTS) times and rates. Purpose: To summarize RTS times and rates for talar OCDs treated by different surgical techniques. Study Design: Systematic review; Level of evidence, 4. Methods: The literature from January 1996 to November 2018 was screened, and identified studies were divided into 7 different surgical treatment groups. The RTS rate, with and without associated levels of activity, and the mean time to RTS were calculated per study. When methodologically possible, a simplified pooling method was used to combine studies within 1 treatment group. Study bias was assessed using the MINORS (Methodological Index for Non-Randomized Studies) scoring system. Results: A total of 61 studies including 2347 talar OCDs were included. The methodological quality of the studies was poor. There were 10 retrospective case series (RCSs) that investigated bone marrow stimulation in 339 patients, with a pooled mean rate of RTS at any level of 88% (95% CI, 84%-91%); 2 RCSs investigating internal fixation in 47 patients found a pooled RTS rate of 97% (95% CI, 85%-99%), 5 RCSs in which autograft transplantation was performed in 194 patients found a pooled RTS rate of 90% (95% CI, 86%-94%), and 3 prospective case series on autologous chondrocyte implantation in 39 patients found a pooled RTS rate of 87% (95% CI, 73%-94%). The rate of return to preinjury level of sports was 79% (95% CI, 70%-85%) for 120 patients after bone marrow stimulation, 72% (95% CI, 60%-83%) for 67 patients after autograft transplantation, and 69% (95% CI, 54%-81%) for 39 patients after autologous chondrocyte implantation. The mean time to RTS ranged from 13 to 26 weeks, although no pooling was possible for this outcome measure. Conclusion: Different surgical treatment options for talar OCDs allow for adequate RTS times and rates. RTS rates decreased when considering patients’ return to preinjury levels versus return at any level.
Majzlanite, K2Na(ZnNa)Ca(SO4)4, a new anhydrous sulfate mineral with complex cation substitutions from Tolbachik volcano
Authors: Siidra Oleg I. , Nazarchuk Evgeny V. , Zaitsev Anatoly N. , Shilovskikh Vladimir V. 
Published: October 2019

AbstractA new mineral majzlanite, ideally K2Na(ZnNa)Ca(SO4)4, was found in high-temperature exhalative mineral assemblages in the Yadovitaya fumarole, Second scoria cone of the Great Tolbachik Fissure Eruption (1975–1976), Tolbachik volcano, Kamchatka Peninsula, Russia. Majzlanite is associated closely with langbeinite and K-bearing thénardite. Majzlanite is grey with a bluish tint, has a white streak and vitreous lustre. The mineral is soluble in warm water. Majzlanite is monoclinic,C2/c,a= 16.007(2),b= 9.5239(11),c= 9.1182(10) Å, β = 94.828(7)°,V= 1385.2(3) Å3andZ= 16. The eight strongest lines of the X-ray powder diffraction pattern are [d, Å (I, %)(hkl)]: 3.3721(40)($\bar{3}$12), 3.1473(56)($\bar{4}$02), 3.1062(65)($\bar{2}$22), 2.9495(50)($\bar{1}$31), 2.8736(100)($\bar{1}$13), 2.8350(70)(421), 2.8031(45)(511) and 2.6162(41)($\bar{5}$12). The following structural formula was obtained: K2Na(Zn0.88Na0.60Cu0.36Mg0.16)(Ca0.76Na0.24)(S0.98Al0.015Si0.005O4)4. The chemical composition determined by electron-microprobe analysis is (wt.%): Na2O 9.73, K2O 15.27, ZnO 11.20, CaO 7.03, CuO 4.26, MgO 1.07, Al2O30.47, SO351.34, SiO20.12, total 100.49. The empirical formula calculated on the basis of 16 O apfu is K1.99Na1.93Zn0.84Ca0.77Cu0.33Mg0.16(S3.94Al0.06Si0.01)O16and the simplified formula is K2Na(Zn,Na,Cu,Mg)Σ2(Ca,Na)(SO4)4. No natural or synthetic compounds directly chemically and/or structurally related to majzlanite are known to date. The topology of the heteropolyhedral framework in majzlanite is complex. An interesting feature of the structure of majzlanite is an edge-sharing of ZnO6octahedra with SO4tetrahedra.
Serum Flt3 ligand is a biomarker of progenitor cell mass and prognosis in acute myeloid leukemia
Authors: Milne Paul , Wilhelm-Benartzi Charlotte , Grunwald Michael R. , Bigley Venetia , Dillon Richard , Freeman Sylvie D. , Gallagher Kathleen , Publicover Amy , Pagan Sarah , Marr Helen , Jones Gail L. , Dickinson Anne M. , Grech Angela , Burnett Alan K. , Russell Nigel H. , Levis Mark , Knapper Steven , Collin Matthew 
Published: October 2019

Key Points
Flt3L is a biomarker of progenitor cell mass in AML. Measurement of Flt3L during induction chemotherapy and follow-up provides prognostic information.
Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia
Authors: Shiba Norio , Yoshida Kenichi , Hara Yusuke , Yamato Genki , Shiraishi Yuichi , Matsuo Hidemasa , Okuno Yusuke , Chiba Kenichi , Tanaka Hiroko , Kaburagi Taeko , Takeuchi Masanobu , Ohki Kentaro , Sanada Masashi , Okubo Jun , Tomizawa Daisuke , Taki Tomohiko , Shimada Akira , Sotomatsu Manabu , Horibe Keizo , Taga Takashi , Adachi Souichi , Tawa Akio , Miyano Satoru , Ogawa Seishi , Hayashi Yasuhide 
Published: October 2019

Key Points
Using RNA-seq in pediatric AML patients, 5 gene rearrangements were newly identified, including NPM1 and RUNX1 gene rearrangements. RNA-seq unmasked the complexity of gene alterations in pediatric AML by identifying disease-causing alterations in nearly all patients.
Induction of activated T follicular helper cells is critical for anti-FVIII inhibitor development in hemophilia A mice
Authors: Jing Weiqing , Chen Juan , Cai Yuanhua , Chen Yingyu , Schroeder Jocelyn A. , Johnson Bryon D. , Cui Weiguo , Shi Qizhen 
Published: October 2019

Key Points
Anti-FVIII inhibitory antibody development is TFH-cell dependent. FVIII restimulation can specifically induce FVIII-primed TFH-cell proliferation.
Gluteus medius muscle function in people with and without low back pain: a systematic review
Authors: Sadler Sean , Cassidy Samuel , Peterson Benjamin , Spink Martin , Chuter Vivienne 
Published: October 2019

Abstract

Introduction
Globally, low back pain (LBP) is one of the greatest causes of disability. In people with LBP, dysfunction of muscles such as the gluteus medius have been demonstrated to increase spinal loading and reduce spinal stability. Differences in gluteus medius function have been reported in those with LBP compared to those without, although this has only been reported in individual studies. The aim of this systematic review was to determine if adults with a history, or current LBP, demonstrate differences in measures of gluteus medius function when compared to adults without LBP.

Methods
MEDLINE, EMBASE, AMED, PsycINFO, PubMED, Pro Quest Database, CINAHL and SPORTDiscus were searched from inception until December 2018 for published journal articles and conference abstracts. No language restrictions were applied. Only case-control studies with participants 18 years and over were included. Participants could have had any type and duration of LBP. Studies could have assessed gluteus medius function with any quantifiable clinical assessment or measurement tool, with the participant non-weight bearing or weight bearing, and during static or dynamic activity. Quality appraisal and data extraction were independently performed by two authors.

Results
The 24 included articles involved 1088 participants with LBP and 998 without LBP. The gluteus medius muscle in participants with LBP tended to demonstrate reduced strength and more trigger points compared to the gluteus medius muscle of those without LBP. The level of activity, fatigability, time to activate, time to peak activation, cross sectional area, and muscle thickness showed unclear results. Meta-analysis was not performed due to the heterogeneity of included studies.

Conclusion
Clinically, the findings from this systematic review should be considered when assessing and managing patients with LBP. Future studies that clearly define the type and duration of LBP, and prospectively assess gluteus medius muscle function in those with and without LBP are needed.

Trial registration
PROSPERO (CRD42017076773).
Intra-articular tranexamic acid as an adjunct to intravenous tranexamic acid for simultaneous bilateral total knee arthroplasty: a randomized double-blind, placebo-controlled trial
Authors: Tsukada Sachiyuki , Kurosaka Kenji , Nishino Masahiro , Maeda Tetsuyuki , Yonekawa Yoshiharu , Hirasawa Naoyuki 
Published: October 2019

Abstract

Background
Intra-articular tranexamic acid (TXA) as an adjunct to intravenous TXA was reported to decrease perioperative blood loss during unilateral total knee arthroplasty (TKA). However, there have been no randomized controlled trials comparing intravenous versus combined intravenous and intra-articular TXA administration in patients undergoing simultaneous bilateral TKA.

Methods
We randomly assigned 77 patients with 154 involved knees undergoing simultaneous bilateral TKA to the intravenous TXA group (intra-articular placebo for each knee) or combined TXA group (1000 mg of intra-articular TXA for each knee) with 1:1 treatment allocation. In both groups, 1000 mg of TXA was given intravenously twice, just before surgery and 6 h after the initial administration. Other perioperative medications, surgical procedures, and blood management strategies were the same for all patients. The primary outcome was perioperative blood loss calculated from blood volume and change in hemoglobin from preoperative to postoperative day 3.

Results
Intention-to-treat analysis showed no statistically significant differences in perioperative blood loss until postoperative day 3 (1067 ± 403 mL in the intravenous TXA group vs. 997 ± 345 mL in the combined TXA group [95% CI, − 240 to 100 mL], P = 0.42). No patients required allogenic blood transfusion. The incidence of thrombotic events did not differ between groups (12% in the intravenous TXA group vs. 9% in the combined TXA group; P = 0.73).

Conclusions
The addition of intra-articular TXA did not reduce perioperative blood loss in patients undergoing simultaneous bilateral TKA compared with placebo.

Trial registration
University Hospital Medical Information Network UMIN000026137. Registered 14 February 2017.
Age-dependent emergence of neurophysiological and behavioral abnormalities in progranulin-deficient mice
Authors: Nagy Dávid , Martens Lauren Herl , Leventhal Liza , Chen Angela , Kelley Craig , Stoiljkovic Milan , Hajós Mihály 
Published: October 2019

Abstract

Background
Loss-of-function mutations in the progranulin gene cause frontotemporal dementia, a genetic, heterogeneous neurodegenerative disorder. Progranulin deficiency leads to extensive neuronal loss in the frontal and temporal lobes, altered synaptic connectivity, and behavioral alterations.

Methods
The chronological emergence of neurophysiological and behavioral phenotypes of Grn heterozygous and homozygous mice in the dorsomedial thalamic—medial prefrontal cortical pathway were evaluated by in vivo electrophysiology and reward-seeking/processing behavior, tested between ages 3 and 12.5 months.

Results
Electrophysiological recordings identified a clear age-dependent deficit in the thalamocortical circuit. Both heterozygous and homozygous mice exhibited impaired input-output relationships and paired-pulse depression, but evoked response latencies were only prolonged in heterozygotes. Furthermore, we demonstrate firstly an abnormal reward-seeking/processing behavior in the homozygous mice which correlates with previously reported neuroinflammation.

Conclusion
Our findings indicate that murine progranulin deficiency causes age-dependent neurophysiological and behavioral abnormalities thereby indicating their validity in modeling aspects of human frontotemporal dementia.
Precocious puberty and Chiari I malformation with syrinx: a case report of an unusual presentation of Costello syndrome
Authors: Schwartz Naomi S. , Regelmann Molly O. 
Published: October 2019

Abstract

Background
Costello syndrome (CS) is a rare RASopathy causing developmental delays, short stature and classically, delayed puberty. We present a patient with CS and central precocious puberty (CPP).

Case presentation
A female patient with CS presented at 6 years 10 months of age with breast development. CPP was biochemically confirmed at 7 years 1 month of age, no additional pituitary dysfunction was noted and puberty progressed at follow-up. Brain magnetic resonance imaging (MRI) revealed a Chiari I malformation with a syrinx, requiring surgical decompression. The patient was successfully treated with histrelin.

Conclusions
Although recent publications do not recommend routine brain MRI in girls with isolated CPP over 6 years of age, in those with CS actionable MRI findings are more likely and imaging should be performed. It is unclear whether the cerebral malformation in the patient contributed to CPP or was an incidental syndromic finding.
A semi-supervised machine learning framework for microRNA classification
Authors: Sheikh Hassani Mohsen , Green James R. 
Published: October 2019

Abstract

Background
MicroRNAs (miRNAs) are a family of short, non-coding RNAs that have been linked to critical cellular activities, most notably regulation of gene expression. The identification of miRNA is a cross-disciplinary approach that requires both computational identification methods and wet-lab validation experiments, making it a resource-intensive procedure. While numerous machine learning methods have been developed to increase classification accuracy and thus reduce validation costs, most methods use supervised learning and thus require large labeled training data sets, often not feasible for less-sequenced species. On the other hand, there is now an abundance of unlabeled RNA sequence data due to the emergence of high-throughput wet-lab experimental procedures, such as next-generation sequencing.

Results
This paper explores the application of semi-supervised machine learning for miRNA classification in order to maximize the utility of both labeled and unlabeled data. We here present the novel combination of two semi-supervised approaches: active learning and multi-view co-training. Results across six diverse species show that this multi-stage semi-supervised approach is able to improve classification performance using very small numbers of labeled instances, effectively leveraging the available unlabeled data.

Conclusions
The proposed semi-supervised miRNA classification pipeline holds the potential to identify novel miRNA with high recall and precision while requiring very small numbers of previously known miRNA. Such a method could be highly beneficial when studying miRNA in newly sequenced genomes of niche species with few known examples of miRNA.
HMNPPID—human malignant neoplasm protein–protein interaction database
Authors: Li Qingqing , Yang Zhihao , Zhao Zhehuan , Luo Ling , Li Zhiheng , Wang Lei , Zhang Yin , Lin Hongfei , Wang Jian , Zhang Yijia 
Published: October 2019

Abstract

Background
Protein–protein interaction (PPI) information extraction from biomedical literature helps unveil the molecular mechanisms of biological processes. Especially, the PPIs associated with human malignant neoplasms can unveil the biology behind these neoplasms. However, such PPI database is not currently available.

Results
In this work, a database of protein–protein interactions associated with 171 kinds of human malignant neoplasms named HMNPPID is constructed. In addition, a visualization program, named VisualPPI, is provided to facilitate the analysis of the PPI network for a specific neoplasm.

Conclusions
HMNPPID can hopefully become an important resource for the research on PPIs of human malignant neoplasms since it provides readily available data for healthcare professionals. Thus, they do not need to dig into a large amount of biomedical literatures any more, which may accelerate the researches on the PPIs of malignant neoplasms.
Prediction of microbial communities for urban metagenomics using neural network approach
Authors: Zhou Guangyu , Jiang Jyun-Yu , Ju Chelsea J.-T. , Wang Wei 
Published: October 2019

AbstractBackgroundMicrobes are greatly associated with human health and disease, especially in densely populated cities. It is essential to understand the microbial ecosystem in an urban environment for cities to monitor the transmission of infectious diseases and detect potentially urgent threats. To achieve this goal, the DNA sample collection and analysis have been conducted at subway stations in major cities. However, city-scale sampling with the fine-grained geo-spatial resolution is expensive and laborious. In this paper, we introduce , a neural network based approach to infer microbial communities at unsampled locations given information reflecting different factors, including subway line networks, sampling material types, and microbial composition patterns.ResultsWe evaluate the effectiveness of based on the public metagenomics dataset collected from multiple locations in the New York and Boston subway systems. The experimental results suggest that consistently performs better than other five conventional classifiers under different taxonomic ranks. At genus level, can achieve F1 scores of 0.63 and 0.72 on the New York and the Boston datasets, respectively.ConclusionsBy exploiting heterogeneous features, captures the hidden interactions between microbial compositions and the urban environment, which enables precise predictions of microbial communities at unmeasured locations.
An adapted eigenvalue-based filter for ocean ambient noise processing
Authors: Wu Guoli , Dong Hefeng , Ke Ganpan , Song Junqiang 
Published: October 2019

Accurate approximations of Green’s functions retrieved from the correlations of ambient noise require a homogeneous distribution of random and uncorrelated noise sources. In the real world, the existence of highly coherent, strong directional noise generated by ships, earthquakes, and other human activities can result in biases in the ambient-noise crosscorrelations (NCCs). We have developed an adapted eigenvalue-based filter to attenuate the interference of strong directional sources. The filter is based on the statistical model of the sample covariance matrix and can separate different components of the data covariance matrix in the eigenvalue spectrum. To improve the effectiveness and make it adaptable for different data sets, a weight is introduced to the filter. Then, the NCCs can be calculated directly from the filtered data covariance matrix. This approach is applied to a 1.02 h data set of ambient noise recorded by a permanent reservoir monitoring receiver array installed on the seabed. The power spectral density indicates that the noise recordings were contaminated by strong directional noise over nearly half of the whole observation period. Beamforming and crosscorrelation results indicate that the interference still exists even after applying traditional temporal and spectral normalization techniques, whereas the adapted eigenvalue-based filter can significantly attenuate it and help to obtain improved crosscorrelations. The approach makes it possible to retrieve reliable approximations of Green’s functions over a much shorter recording time.