bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMPARISON OF REQUIREMENTS OF ANNEX 1 TO THE RULES OF GOOD MANUFACTURING PRACTICE OF THE EURASIAN ECONOMIC UNION AND REQUIREMENTS OF THE DRAFT ANNEX 1 GMP PIC/S
Authors: Basevich Anna V. , Kaukhova Irina E. , Kodash Artemy A. , Bitkina Tatyana A. , Smirnova Elena M. , Stepchenkov Vladimir I. 
Published: June 2020

This article provides an overview on draft GMP EC Annex 1 revision progress and, as a consequence, the GMP PIC/S. The role and position of Russia in the pharmaceutical market, its inclusion in international organizations involved in the regulation of the production and circulation of drugs has been indicated. The interconnection between economic integration processes, changes in international regulatory requirements and national legislation has been demonstrated.
The article shows how changes in the laws governing the pharmaceutical industry entail changes in the organization of manufacturing or in the approach to the manufacturing process at the organizational level and/or lead to material expenses to eliminate incompliance. Keeping track of possible future changes in legislation allows to pre-build a plan for eliminating incompliance. When analyzing the changes in the Draft Appendix 1 regarding the current version of Appendix 1, it has been revealed that the documents have significant differences. To eliminate significant incompliances with a number of paragraphs of the draft Appendix 1, it is necessary to make changes not only in the operating procedures, but also in the planning solutions of production sites.
Based on the results of the work carried out, it has been established that the introduction of the draft Annex 1 GMP PIC/S and its implementation in the GMP EAEU requirements will lead to incompliance at existing pharmaceutical enterprises, the elimination of which requires a lot of organizational work. Significant changes at the existing enterprise are required in accordance with 14 points of the draft. This article presents clauses 5.9, clause 5.21, clause 8.7, clause 8.16, clause 8.29, clause 9.17, clause 9.33 - this is due to that most of these requirements are absent in the current valid requirements of GMP EAEU and Russian GMP rules.
The comparison made is an occasion for pharmaceutical companies to conduct internal audits for compliance with the requirements of the draft GMP PIC/S Annex 1 in order to preventively identify incompliances and develop an action plan to address them.
Riski Seven ve Riskten Kaçan Yatırımcıların Optimum Portföy Seçimi Yapabilecekleri Piyasalar1
Authors: ÇAKAR Recep , ÖZKAN Oktay 
Published: June 2020

Çalışmanın amacı, riski seven ve riskten kaçan yatırımcı tiplerini, optimum portföy
oluşturabilecekleri pazarlara yönlendirmektir. Ayrıca bu iki yatırımcı tipi için en uygun
piyasaların hangileri olduğu tespiti de yapılacaktır. Bu amaçla çalışmada, 2017 Dünya Bankası
verilerine göre gelişmiş ve gelişmekte olan 20 ülkenin piyasalarını temsil eden pazar endekslerinin
2010-2017 yılları arasındaki aylık getiri verileri kullanılmıştır. Pazar endekslerinin verileri
kullanılarak Kuadratik Ortalama-Varyans Modeli ile optimum portföyler oluşturulmuş ve her
bir pazar endeksinin değişim katsayısı hesaplanmıştır. Gelişmiş ve gelişmekte olan ülke
piyasalarının endeks bazında riskleri de hesaplanarak, hangi endekslerin hangi yatırımcı tipleri
için rasyonel olacağı tespit edilmiştir. Gerçekleştirilen analiz sonuçlarına göre, riski seven
yatırımcı tipileri için optimum portföyler Venezuela, Tayland, Meksika, Malezya, Kosta Rika,
Arjantin ve Güney Afrika pazar endekslerinde oluşturabileceği ve aynı zamanda bu yatırımcılar
için endeks bazında en riskli olan piyasaların Venezuela, Arjantin ve Kazakistan olduğu
anlaşılmıştır. Riskten kaçan yatırımcıların optimum portföylerini İzlanda, ABD ve Norveç
endeksleriyle oluşturabileceği ve aynı zamanda bu yatırımcılar için endeks bazında en risksiz olan
piyasaların İngiltere, İsviçre ve Kanada olduğu sonuçlarına ulaşılmıştır.
Ekonomik ve Mali Boyutlarıyla Robot Vergisi
Authors: TURAN Deniz 
Published: June 2020

21. yüzyılda robot teknolojisinde yaşanan hızlı gelişmeler, toplumu ve ekonomiyi temelden
dönüştürmeye başlamıştır. Günümüzde üretimden hizmet sektörüne kadar her alanda yaygın
şekilde kullanılan ve ekonomik verimliliği artırması yanında teknolojik işsizliğe de yol açan akıllı
robotların vergilendirilmesi konusu ekonomik ve sosyal boyutları ile ele alınmaya başlanmıştır.
Yapılan çalışma, robotların işgücü piyasası, gelir dağılımı ve kamu mali dengesi üzerine
etkilerinin incelenerek bir robot vergisinin gerekliliğinin ekonomik gerekçeleri açıklığa
kavuşturmayı amaçlamaktadır. Bu çalışmanın bulguları şunlardır; Robot teknolojisi işgücü
piyasasında yeni bir küresel dengenin oluşmasına yol açacaktır. Toplumda gelirin küçük bir
sermayedar kesimde toplanmasına engel olmak ve otomasyon devriminden olumsuz etkilenenlere
potansiyel olarak yardımcı olmak amacıyla robotların elektronik kişi sıfatıyla yasal bir kişilik
tanımlanması ve robot vergisi alınması gerekmektedir.
Psikolojik Sermaye Düzeylerinin İş Tatmini Üzerine Etkisi: Üniversite Çalışanları Üzerine Bir Araştırma
Authors: ÇETİNKAYA Fatih Ferhat , ÜNSEVER Mehmet Orkun 
Published: June 2020

Bu çalışmada Kırşehir Ahi Evran Üniversitesi’nde çalışan İdari ve Akademik Personelin
psikolojik sermaye düzeyleri iş tatminleri arasındaki ilişkileri tespit etmek amaçlanmıştır.
Araştırma ilgili literatüre destek sağlayacağı düşünüldüğü için önemli görülmüştür.
Araştırmanın verileri anket tekniğiyle toplanmıştır. Veriler SPSS 23.0 paket programı ile analize
tabi tutulmuştur. Araştırmada kullanılan ölçeklerin ilk olarak güvenilirlik ve geçerlilik testleri
yapılmıştır. Ölçeklerin geçerlilik ve güvenilirliği sağladığı tespit edildikten sonra , verilerin normal
dağılıp dağılmadığını tespit etmek için ölçeklerin çarpıklık-basıklık değerlerine bakılmıştır. Daha
sonra değişkenler arasındaki ilişkileri ölçmek için, Korelasyon ve Regresyon analizleri yapılmıştır.
Yapılan korelasyon analizi neticesinde psikolojik sermaye ile iş tatmini arasında pozitif yönlü ve
istatistiksel açıdan anlamlı bir ilişkinin olduğu tespit edilmiştir. Psikolojik sermayenin alt
boyutları olan özyeterlilik, umut, esneklik ve iyimserlik ile iş tatmini arasında da pozitif yönlü
istatistiksel açıdan anlamlı ilişkilerin olduğu görülmüştür. Psikolojik sermayenin alt boyutlarının
birlikte iş tatmini üzerine etkisini belirlemek amacıyla yapılan çoklu regresyon analizi sonucunda
ise 4 alt boyutun bir arada modele sağladığı katkının istatistiksel açıdan anlamlı olduğu
belirlenmiştir (p
Corneal edema due to botanical toxins
Authors: Chakraborty Soumen , Kumar Agrawalla Ratandep 
Published: June 2020

Corneal edema following contact with plant extracts occur not only with horticultural workers but also with amateur gardeners. The condition causes reasonable visual debility but is reversible and self limiting. Till date, no established therapeutic protocol exists for management of this particular condition.To re-examine the etiological factors behind this condition and to develop a definitive therapeutic prescript for this problem.Forty six patients suffering from this condition were randomly divided into two equal groups. Group A was treated with topical steroids (commercially available moxifloxacin 0.5% w/v + dexamethasone sodium phosphate 0.1% w/v), whereas Group B was treated with a placebo (carboxy methylcellulose 0.5% w/v). All patients were monitored on alternate days in terms of BCVA, non contact tonometry and slit lamp examination. Pachymetry was done on arrival and after complete resolution of corneal edema.In both the groups, corneal edema resolved in all eyes by the fifth day without any residual clinical deficit. The mean pachymetry value on presentation in Group A was 626 microns and in Group B was 628 microns, and returned to 550 microns or below by day five in all patients. Visual acuity was restored to 6/9 or better in all patients of Group B and 96% (n= 22) patients in Group A, but this deficiency was not related to the disease process in question.Botanical toxin induced corneal edema was self limiting and resolved in a time bound pattern without any sequel. Topical steroids neither seemed to hasten the resolution of corneal edema nor affected the final outcome of this clinical condition in any way.
Descartes (and Spinoza) on Intellectual Experience and Skepticism
Authors: Carriero John 
Published: June 2020

Kartezjusz (i Spinoza) w kwestii intelektualnego doświadczenia i sceptycyzmu
Epistemologia Kartezjusza jest zakorzeniona w jego głębokim zainteresowaniu i uznaniu dla tego, co można by nazwać intelektualnym doświadczeniem, lub dokładniej przejrzystym intelektualnym doświadczeniem (przejrzyste intelektualne doświadczenie jest moim terminem oznaczającym to, co Kartezjusz określał ujęciem jasnym i wyraźnym). To zainteresowanie intelektualnym doświadczeniem, jak mi się wydaje, podzielali inni racjonaliści, Spinoza i Leibniz. W części pierwszej artykułu staram się ulokować fenomen przejrzystego intelektualnego doświadczenia w ramach doktryny Kartezjusza i Spinozy. Usiłuję pokazać, że jeśli nie uwzględnimy w sposób właściwy charakteru tego doświadczenia, to ryzykujemy utratą wglądu w centralne motywy leżące u podstaw ich teorii poznania. W drugiej części artykułu rozważam intelektualne doświadczenia w kontekście sceptycznego wątpienia, w szczególności radyklanego wątpienia. Chociaż często przyjmuje się, że Kartezjusz i Spinoza zajmują opozycyjne stanowiska, gdy chodzi o kwestię radykalnego wątpienia, to ja sądzę, że ich stanowisko były bardziej do siebie podobne w tej sprawie niż się zwykle przyjmuje.
Fraud and Misconduct in Publishing Medical Research
Authors: Elsayed Dya Eldin Mohammed 
Published: June 2020

One of the important feature of scientific research is scrutinizing truth. Investigators strive for honesty and integrity in all scientific communications. Candidly reported methods and procedures, data and results, and their publication status should reflect authenticity. Publication of fake data diverts the search from truth. The aim of studying human subjects should be advancing research and scholarship and not just the researcher’s own career. Misconduct in medical research is any intentional deviation from acceptable ethical principles. Intentional misconduct is a serious observation, and misconduct such as falsification and fabrication of data and plagiarism are the most common fraud practices in medical research. Misconduct can occur at any stage of the research process; however, it particularly occurs in the results section of the research as researchers try to avoid negative findings. Data falsification occurs when investigators attempt to alter data to meet their own expectations. Falsification could involve altering data and results on research participants’ record to fit research report. Data fabrication occurs when researchers report data that were completely constructed and never occurred when running the research. Plagiarism is using—either deliberate or inattentive—other researchers’ ideas and words without clearly acknowledging the source of that information. Although fraud and misconduct have serious consequences, they are not uncommon among research publications in scientific journals. Institutions have to develop a mechanism to discover research misconduct and to prevent it. Editors and reviewers are required to introduce some commentaries in the regulations to impose sanctions on those found guilty of research misconduct.
Key words: research, fraud, misconduct
A Systems Thinking Approach for the Creation of Super Clinicians using a Competency-based Medical Education Framework
Authors: Hassan Imad 
Published: June 2020

We think that the article titled “National Competency Frameworks for Medical Graduates: Is it Time for the “SudanMeds”? published in the Sudan Journal of Medical Sciences [1] is a timely publication. Competency-based medical education (CBME) is considered as a paradigm shift in medical education, the ultimate aim of which is the improvement of patient and society’s quality of care by training and creating highly skilled clinicians. A paradigm as defined by the Cambridge Dictionary is a situation in which the usual and accepted way of doing or thinking about something changes completely. The magnitude of change is so profound to the extent that it leads to a fundamental change in the approach or underlying assumptions, an example being the introduction of the Internet. Several such major “contemporary” shifts have colored the thinking processes and actions of healthcare professionals and leaders. For example, the Patient Safety Paradigm and the Evidence-based Practice Paradigm.
Menstrual Disorders Among Nursing Students at Al Neelain University, Khartoum State
Authors: Ali Aisha , Khalafala Huda , Fadlalmola Hammad 
Published: June 2020

Background: Menstrual disorders can severely affect the daily life of young females, particularly the student population, which generates a massive tension that extends to families, but they seldom affect the quality and standard of life.
Objectives: The aim of this study was to determine the morbidity nature of menstrual disorders among nursing students and their effect on students’ life activities.
Methods: This study was a descriptive cross-sectional institutional-based study conducted at the Al Neelain University, Faculty of Nursing. Of the 200 students recruited, 149 completed the questionnaire with the responding rate of (74.5%). Data were collected using a self-administered structured questionnaire.
Results: Of the 149 participants, most were young and in the age range of 18–24 years with a mean age of 21 years. Most students (74%) started their menarche at a normal age range of 12–15 years. A relatively high dysmenorrhea (94.0 %) was observed among the participants. More than half of the respondents (55.0%) had irregular menstruation.
Conclusion: The authors concluded that the prevalence and morbidity of dysmenorrhea and menstrual irregularity were high but broadly comparable to those observed in similar developing countries. Therefore, national health policies need to consider the health and educational impact of menstrual disorders on nursing students and develop the plan through a change in students’ lifestyle; moreover, school authorities and teachers need to be aware of the problems to provide psychological and academic support.
Keywords: morbidities, dysmenorrhea prevalence, menstrual disorders, nursing students, irregular menstruation
Adopting ISO/IEC 27005:2011-based Risk Treatment Plan to Prevent Patients Data Theft
Authors: Hamit Laura Cassandra , Md. Sarkan Haslina , Mohd Azmi Nurulhuda Firdaus , Mahrin Mohd Naz’ri , Chuprat Suriayati , Yahya Yazriwati 
Published: June 2020

The concern raised in late 2017 regarding 46.2 million mobile device subscribers’ data breach had the Malaysian police started an investigation looking for the source of the leak. Data security is fundamental to protect the assets or information by providing its confidentiality, integrity and availability not only in the telecommunication industry but also in other sectors. This paper attempts to protect the data of a patient-based clinical system by producing a risk treatment plan for its software products. The existing system is vulnerable to information theft, insecure databases, needy audit login and password management. The information security risk assessment consisting of identifying risks, analyzing and evaluating them were conducted before a risk assessment report is written down. A risk management framework was applied to the software development unit of the organization to countermeasure these risks. ISO/IEC 27005:2011 standard was used as the basis for the information security risk management framework. The controls from Annex A of ISO/IEC 27001:2013 were used to reduce the risks. Thirty risks have been identified and 7 high-level risks for the product have been recognized. A risk treatment plan focusing on the risks and controls has been developed for the system to reduce these risks in order to secure the patients’ data. This will eventually enhance the information security in the software development unit and at the same time, increase awareness among the team members concerning risks and the means to handle them.
Supervised Image Classification of Chaos Phenomenon in Cumulonimbus Cloud Using Spectral Angle Mapper
Authors: Wanayumini - , Sitompul Opim Salim , Suwilo Saib , Zarlis Muhammad 
Published: June 2020

In the field of remote sensing, in addition to the weather forecast, atmospheric dynamics, oceans, cloud cumulonimbus, and Tornado are part of the phenomenon of chaos. Because in the clouds cumulonimbus, there are some layers with a gray border indicating irregular and uncertain. There is a boundary line on the layers of Cumulonimbus Clouds that could be identified based on the pixel where the differences in the intensity values are extremes. A cloud layer cumulonimbus with a gray edge border can be used as the basis for predicting the occurrence of a tornado based on a pixel location that has specific characteristics. In this research, a Supervised Image Classification algorithm with Spectral Angle Mapper was performed to get the minimum and maximum pixel intensity interval values based on spectral angles in cumulonimbus clouds. Spectral angles allow for quick mapping in determining the spectral similarities between two spectrums on cumulonimbus cloud layers. The spectral similarities are calculated by referring to the angle between the spectral forming the same dimensional vector space on the RGB color spectrum. Early detection in cumulonimbus cloud layers will indicate the occurrence of chaos phenomenon, which could be used to predict tornadoes. The results showed that the Spectral Angle Mapper approach gave minimum and maximum pixel intensity values interval of the Average Correlation Angle in the dataset image Cumulonimbus Cloud with a classification accuracy value of 95.83%.
Development Barriers of Stingless Bee Honey Industry in Bicol, Philippines
Authors: Hidalgo Hanilyn A. , Nicolas Amelia R. , Cedon Romnick 
Published: June 2020

Beekeeping industry in Bicol, Philippines is dominated by stingless beekeepers. Tetragonula biroi, is an endemic stingless bee species in the region, which produces the most expensive honey in the local commercial market. However, beekeeping industry remains to be part of the informal business sector under the shadow of rural enterprises. Improving the industry’s economic contribution would mean upgrading the chain through which beekeeping sector passes through. The purpose of the study is to assess the barriers in developing the stingless bee honey industry. The value chain approach was used in determining the issues along each chain level and in finding ways to strengthen the competitiveness of the industry. Results show that there is not enough support programs given to sustain the drive towards an efficient commodity flow of honey. The demand is high but there are few enablers to strengthen the flow of the commodity. The findings revealed seven development barriers: stability of honey supply, product standardization; product traceability; harvesting and processing policies; entrepreneurial support program; vulnerability to natural disasters; and research programs. Similar to farming, stingless beekeeping is a promising enterprise that is largely dependent on climatic condition. The risks associated with climate change and environment limit people from seriously pursuing stingless beekeeping as an entrepreneurial venture. To strengthen the industry, stakeholder’s collaboration must be institutionalized to create strong business linkages among the chain operators. The distinctive characteristic of stingless bee honey should be positioned in a market niche that matches its benefit to target users. A review must be done on the provisions in the Code of Good Beekeeping Practices as regards the production chain of raw honey and its by-products to ensure that honey sold is of good quality, with fair price, and easily traceable.
Profil FTIR Minyak Ikan dan Lemak Babi serta Perbandingannya sebagai Dasar Penentuan Autentifikasi Halal
Authors: Megawati Dewi Sinta , Fauziyah Begum , Maimunah Siti , Wafi Abdul 
Published: June 2020

<p>Research has been conducted on the determination of tuna oil and lard spectra using FTIR. This research aims to determine the IR spectra profile of lard and tuna oil and to compare both spectra profiles. Profile and comparison of lard and tuna oil IR spectra useful to determine whether an ingredient or a product contaminated with lard. The fatty acid profile of lard by FTIR analysis showed a significant difference in the absorption patterns of the spectra, especially at 3010-3000, 1680- 1600, and 968-966 cm-1 wavenumbers which represented the different composition and type of fatty acids in the lard and tuna oil. The absorption patterns at 3007 and 1653 cm-1 regions (double bond C=C cis) for tuna oil showed relatively high peaks if it is compared to lard samples because of the percentage of MUFA fatty acids (oleic acid) in tuna oil was much higher. </p><p> </p><p>Telah dilakukan penelitian mengenai penentuan spektra minyak ikan tuna dan lemak babi dengan menggunakan FTIR. Penelitian ini bertujuan untuk mengetahui profil spektra IR dari lemak babi dan minyak ikan tuna serta membandingkan kedua profil spektranya. Profil dan perbandingan spektra IR lemak babi dan minyak ikan tuna dapat digunakan sebagai dasar penentuan apakah suatu bahan atau produk terkontaminasi lemak babi. Profil asam lemak babi hasil analisis FTIR menunjukkan adanya perbedaan yang cukup signifikan pada pola-pola penyerapan spektra, khususnya pada bilangan gelombang 3010-3000, 1680-1600 dan 968-966 cm-1 yang merepresentasikan perbedaan komposisi dan jenis asam lemak pada sampel lemak babi dan minyak ikan tuna. Pola serapan pada bilangan gelombang 3007 dan 1653 cm-1 (ikatan rangkap C=C cis) untuk sampel minyak ikan tuna menunjukkan puncak yang relatif tinggi jika dibandingkan dengan sampel lemak babi karena persentase asam lemak MUFA (asam oleat) pada minyak ikan tuna jauh lebih tinggi. </p>
Meningkatkan Kemandirian Santri Melalui Pendampingan Konseling Sebaya (Peer Counseling)
Authors: Sadiyah Elok Halimatus , Hidayati Fina 
Published: June 2020

<p><strong>Abstrak</strong>. Pesantren merupakan alternative terbaik dalam dunia pendidikan untuk mencetak santri tumbuh dan berkembang menjadi pribadi yang religious, disiplin dan mandiri. Namun, kenyataan di lapangan tantangannya sangat berat, sehingga diperlukan program pendukung dalam efektifitas peningkatan kemandirian pada santri, salah satunya yakni melalui konseling sebaya (<em>peer counseling</em>). Tujuan penelitian ini memaparkan peningkatkan kemandirian santri melalui pendampingan konseling sebaya di Pesantren Darunnajah Karangploso Malang, melibatkan santri sebanyak 406 santri. Metode yang digunakan adalah <em>action research, </em> dengan pertanyaan penelitian utama adalah bagaimana pendampingan konseling sebaya dapat meningkatkan kemandirian santri. Hasil penelitian membuktikan bahwa model konseling sebaya (<em>peer counseling</em>) di Pesantren Darunnajah Malang meningkatkan kemandirian santri melalui: <em>pertama, </em>ketrampilan pemecahan masalah Santri dengan teman sebaya. <em>Kedua, </em>kemampuan santri belajar mengontrol perilaku. <em>Ketiga,t</em>eman sebaya mampu memberikan dukungan sosial, moral dan emosional. <em>Keempat, </em>Kelompok teman sebaya mampu memberikan dukungan sosial dan motivasi.</p><p><strong>Kata Kunci</strong>: Konseling sebaya, Santri, Kemandirian</p><p> </p>