bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fusion of intra-oral scans in cone-beam computed tomography scans
Authors: Baan F. , Bruggink R. , Nijsink J. , Maal T. J. J. , Ongkosuwito E. M. 
Published: June 2020

Abstract
Purpose
The purpose of this study was to evaluate the clinical accuracy of the fusion of intra-oral scans in cone-beam computed tomography (CBCT) scans using two commercially available software packages.

Materials and methods
Ten dry human skulls were subjected to structured light scanning, CBCT scanning, and intra-oral scanning. Two commercially available software packages were used to perform fusion of the intra-oral scans in the CBCT scan to create an accurate virtual head model: IPS CaseDesigner® and OrthoAnalyzer™. The structured light scanner was used as a gold standard and was superimposed on the virtual head models, created by IPS CaseDesigner® and OrthoAnalyzer™, using an Iterative Closest Point algorithm. Differences between the positions of the intra-oral scans obtained with the software packages were recorded and expressed in six degrees of freedom as well as the inter- and intra-observer intra-class correlation coefficient.

Results
The tested software packages, IPS CaseDesigner® and OrthoAnalyzer™, showed a high level of accuracy compared to the gold standard. The accuracy was calculated for all six degrees of freedom. It was noticeable that the accuracy in the cranial/caudal direction was the lowest for IPS CaseDesigner® and OrthoAnalyzer™ in both the maxilla and mandible. The inter- and intra-observer intra-class correlation coefficient showed a high level of agreement between the observers.

Clinical relevance
IPS CaseDesigner® and OrthoAnalyzer™ are reliable software packages providing an accurate fusion of the intra-oral scan in the CBCT. Both software packages can be used as an accurate fusion tool of the intra-oral scan in the CBCT which provides an accurate basis for 3D virtual planning.
Effects of tectonically induced fabrics on geomechanical properties of rocks, NW Pakistan
Authors: Ali Asghar , Hussain Saddam , Khan Shehzad , Khan Awal Sher , Mabood Sohail , Ahmad Rafique 
Published: June 2020

AbstractThe Chakdara Granitic Gneisses (CGG) of the Indian plate and Kamila Amphibolite of the Kohistan Island Arc (KIA) along the Main Mantle Thrust (MMT) in Shigo Kas, Talash Dir Lower, indicate that tectonically induced foliations and lineations strongly affected the geomechanical properties of these rocks. The earlier S1 crenulated cleavages are well preserved in the microlithon of a well-developed ENE-WSW trending S2 crenulation cleavage. The pervasive S2 foliations, D2 fold axes, and L22 lineations are induced by NNW-SSE horizontal bulk shortening. The core samples obtained parallel and perpendicular to the main ENE-WSW trending S2 and L22 have higher and lower uniaxial compressive strength (UCS) values, respectively. The UCS and uniaxial tensile strength (UTS) average values of four core samples obtained parallel and perpendicular to the main S2 are 51.8 MPa and 12.21 MPa versus 45.65 MPa and 12.45 MPa, respectively. Core samples from the weakly foliated S-2 specimen shows little variation in the UCS and UTS values. The variation in the UCS values in the core samples cut perpendicular and parallel to the main tectonic fabric has been controlled by micro-shear zones at the contact zones of crenulated and crenulation cleavages and sigmoidal mica fish. The UCS values are higher in the core samples parallel to the pervasive S2 and L22 because the parallel shear on the sigmoidal crenulated cleavages in microlithon of the S2 and S2 mica fish counterbalance the parallel external applied load. However, the UCS values decrease in the core samples that were cut perpendicular to the pervasive S2 and L22 because the perpendicular shear on the sigmoidal crenulated cleavages in microlithon of the S2 and S2 mica fish enhances the external applied load, which lead to the failure of core samples.
Can metabolic profiling provide a new description of osteoarthritis and enable a personalised medicine approach?
Authors: Jaggard M. K. J. , Boulangé C. L. , Graça G. , Vaghela U. , Akhbari P. , Bhattacharya R. , Williams H. R. T. , Lindon J. C. , Gupte C. M. 
Published: June 2020

AbstractOsteoarthritis (OA) is a multifactorial disease contributing to significant disability and economic burden in Western populations. The aetiology of OA remains poorly understood, but is thought to involve genetic, mechanical and environmental factors. Currently, the diagnosis of OA relies predominantly on clinical assessment and plain radiographic changes long after the disease has been initiated. Recent advances suggest that there are changes in joint fluid metabolites that are associated with OA development. If this is the case, biochemical and metabolic biomarkers of OA could help determine prognosis, monitor disease progression and identify potential therapeutic targets. Moreover, for focussed management and personalised medicine, novel biomarkers could sub-stratify patients into OA phenotypes, differentiating metabolic OA from post-traumatic, age-related and genetic OA. To date, OA biomarkers have concentrated on cytokine action and protein signalling with some progress. However, these remain to be adopted into routine clinical practice. In this review, we outline the emerging metabolic links to OA pathogenesis and how an elucidation of the metabolic changes in this condition may provide future, more descriptive biomarkers to differentiate OA subtypes.
Rheumatology-led pregnancy clinic: enhancing the care of women with rheumatic diseases during pregnancy
Authors: El Miedany Yasser , Palmer Deborah 
Published: June 2020

AbstractThe autoimmune rheumatic diseases have a clear predilection for women. Consequently, issues regarding family planning and pregnancy are a vital component of the management of these patients. Not only does pregnancy by itself causes physiologic/immunologic changes that impact disease activity but also women living with inflammatory arthritic conditions face the additional challenges of reduced fecundity and worsened pregnancy outcomes. Many women struggle to find adequate information to guide them on pregnancy planning, lactation and early parenting in relation to their chronic condition. This article discusses the gaps in the care provided to women living with inflammatory arthritis in standard practice and how a rheumatology nurse-led pregnancy clinic would fill such gap, consequently enhance the care provided and ensure appropriate education is provided to these individuals who represent the majority of the patients attending the rheumatology outpatient clinics. Such specialist care is expected to cover the whole journey as it is expected to provide high-quality care before, during and after pregnancy.
Re-evaluating natural resource investments under uncertainty: An alternative to limited traditional approaches
Authors: Maier Sebastian 
Published: June 2020

AbstractThe need to evaluate natural resource investments under uncertainty has given rise to the development of real options valuation; however, the analysis of such investments has been restricted by the capabilities of existing valuation approaches. We re-visit the well-known example of a copper mine project under a one-factor and two multi-factor models using the influence diagram simulation-and-regression (IDSR) approach. The one-factor setting was originally proposed by Brennan and Schwartz (J Bus 58(2):135–157, 1985), who used partial differential equations (PDEs) and finite differences to approximately solve the valuation problem; extensions to two and three factors were later analysed by Tsekrekos et al. (Eur Financ Manag 18(4):543–575, 2012) using the least-squares Monte Carlo method. We apply the IDSR approach to perform a detailed portfolio analysis of the one-factor benchmark investment and find issues in both the definitions and values of the fixed-output-rate mine and closure option at the portfolio decomposition stage in Brennan and Schwartz (1985). We then apply the IDSR approach to re-evaluate two multi-factor extensions of Tsekrekos et al. (2012) and detect issues in their sensitivity analyses that impact on the reliability of some of their findings. To confirm this and validate the values we obtained, we integrate PDE-based analytical expressions that describe the volatilities implied by the multi-factor models into our IDSR-based analysis. Using the investment-uncertainty relationship, we are able to correctly analyse the impact of the complex multi-factor model parameters on investment value. We conclude that the limitations of PDE-based finite difference approaches may invalidate their use in portfolio situations, but analytical expressions obtained from PDE-based modelling may be profitably integrated into a simulation-based, numerical analysis to validate results and gain new insights.
The Eulerian Stochastic Fields Method Applied to Large Eddy Simulations of a Piloted Flame with Inhomogeneous Inlet
Authors: Hansinger Maximilian , Zirwes Thorsten , Zips Julian , Pfitzner Michael , Zhang Feichi , Habisreuther Peter , Bockhorn Henning 
Published: June 2020

AbstractLarge Eddy Simulations of the Sydney mixed-mode flame with inhomogeneous inlet (FJ200-5GP-Lr75-57) are performed using the Eulerian Stochastic Fields (ESF) transported probability functions method to account for the sub-grid scale turbulence–chemistry interaction, to demonstrate the suitability of the ESF method for mixed-mode combustion. An analytically reduced 19-species methane mechanism is used for the description of the chemical reactions. Prior to the reactive case, simulation results of the non-reactive setup with cold and hot pilot stream are presented, which show differences in the jet breakup and radial species mass fluxes. The reactive case simulations are compared to experimental data and a recently conducted model free quasi-DNS (qDNS), showing very good agreement with the qDNS in terms of scatter data and radial mean values of temperature and species distribution, as well as mixture fraction conditional statistics. Further analysis is dedicated to sub-grid scale statistics, showing that mixture fraction and reaction progress variable are strongly correlated in this flame. The impact of the number of stochastic fields on the filtered temperature and species distribution is investigated; it reveals that the ESF method in conjunction with finite-rate chemistry is very insensitive to the number of employed fields to obtain highly accurate simulation results.
Flow cytometric detection of hyper-polarized mitochondria in regulated and accidental cell death processes
Authors: Warnes G. 
Published: June 2020

AbstractShikonin induced necroptosis in Jurkat cells were identified flow cytometrically by the up-regulation of RIP3 in live cells and that a proportion of these cells underwent other forms of regulated cell death (RCD) which included parthanatos (< 10%), or cleaved PARP (< 10%) and DNA Damage (> 30%). Live necroptotic cells also possessed functioning mitochondria with hyper-polarized mitochondria membrane potential and generated a fivefold increase in cellular reactive oxygen species (ROS) which was resistant to inhibition by zVAD and necrostatin-1 (Nec-1). After loss of plasma membrane integrity these dead necroptotic cells then showed a higher incidence of parthanatos (> 40%), or cleaved PARP (> 15%) but less DNA Damage (< 15%). Inhibition of shikonin induced apoptosis and necroptosis by zVAD and Nec-1 respectively resulted in live necroptotic cells with an increased incidence of cleaved PARP and reduced levels of DNA Damage respectively. Dead necroptotic cells then showed a reduced incidence of parthanatos and DNA Damage after inhibition by zVAD and Nec-1 respectively. A high proportion of these dead necroptotic cells (30%) which lacked plasma membrane integrity also displayed functioning hyper-polarized mitochondria with high levels of cellular ROS and thus had the capacity to influence the outcome of RCD processes rather than just been the end product of cell death, the necrotic cell. Flow cytometry can thus measure multiple forms of RCD and the level of cellular ROS and MMP which highlights the inter-connection between cell death processes and that a single cell may simultaneously display multiple forms of RCD.
Low-dose metronomic chemotherapy as an efficient treatment option in metastatic breast cancer—results of an exploratory case–control study
Authors: Krajnak S. , Schnatz C. , Almstedt K. , Brenner W. , Haertner F. , Heimes A.-S. , Lebrecht A. , Makris G.-M. , Schwab R. , Hasenburg A. , Schmidt M. , Battista M. J. 
Published: June 2020

Abstract
Purpose
There is growing interest in low-dose metronomic chemotherapy (LDMC) in metastatic breast cancer (MBC). In this retrospective case–control analysis, we compared the efficacy of LDMC and conventional chemotherapy (CCT) in MBC.

Methods
Each LDMC patient receiving oral cyclophosphamide (CTX) (50 mg daily) and methotrexate (MTX) (2.5 mg every other day) was matched with two controls who received CCT. Age, number of chemotherapy lines and metastatic sites as well as hormone receptor (HR) status were considered as matching criteria. Primary endpoint was disease control rate longer than 24 weeks (DCR). Secondary endpoints were progression-free survival (PFS), duration of response (DoR) and subgroup analyses using the matching criteria.

Results
40 cases and 80 controls entered the study. 30.0% patients with LDMC and 22.5% patients with CCT showed DCR (p = 0.380). The median PFS was 12.0 weeks in both groups (p = 0.218) and the median DoR was 31.0 vs. 20.5 weeks (p = 0.383), respectively. Among younger patients, DCR was 40.0% in LDMC vs. 25.0% in the CCT group (p = 0.249). DCR was achieved in 33.3% vs. 26.2% non-heavily pretreated patients (p = 0.568) and in 36.0% vs. 18.0% patients without multiple metastases (p = 0.096), respectively. In the HR-positive group, 30.0% LDMC vs. 28.3% CCT patients showed DCR (p = 1.000). Among triple-negative patients, DCR was achieved in 30.0% LDMC and 5.0% CCT patients (p = 0.095).

Conclusions
We demonstrated a similar efficacy of LDMC compared to CCT in the treatment of MBC. Thus, LDMC may be a valuable treatment option in selected MBC patients.
How to Regulate the Right to Self-Medicate
Authors: Roberts Joseph T. F. 
Published: June 2020

AbstractIn Pharmaceutical Freedom Professor Flanigan argues we ought to grant people self-medication rights for the same reasons we respect people’s right to give (or refuse to give) informed consent to treatment. Despite being the most comprehensive argument in favour of self-medication written to date, Flanigan’s Pharmaceutical Freedom leaves a number of questions unanswered, making it unclear how the safe-guards Flanigan incorporates to protect people from harming themselves would work in practice. In this paper, I extend Professor Flanigan’s account by discussing a hypothetical case to illustrate how these safe-guards could work together to protect people from harms caused by their own ignorance or incompetence.
The Epistemological Contribution of the Transcendental Reduction
Authors: Vincini Stefano 
Published: June 2020

AbstractIn order to appreciate the rich implications of the transcendental reduction, one has to distinguish the different contexts where it acquires different meanings. The present paper focuses on a particular epistemological context and clarifies the contribution of the reduction within this context. The contribution consists in the formulation and solution of the problem of exhibiting the evidence supporting the belief in the world’s existence. In a nutshell, world-experience grounds the world-belief and world-experience entails a bedrock of experience legitimizing the positing of others. I argue that this contribution is possibly an enduring achievement of Husserl’s transcendental philosophy against common objections that are raised against it. I show that both the necessity and the viability of the transcendental reduction are a consequence of the general structure of critical examination. Overall, a picture of Husserl’s philosophy emerges that emphasizes embodiment, intersubjectivity, and facticity without giving up the rigor of radical epistemological analysis, aiming at overcoming both naïve pseudo-problems and subtle forms of dogmatism.
Red light gentrification in Soho, London and De Wallen, Amsterdam
Authors: Singelenberg Marthe , van Gent Wouter 
Published: June 2020

AbstractMany European city centres have seen increasing investment in the last decades, and policies have targeted centrally-located red light districts in particular for regeneration and clean-up. The literature tends to discuss these interventions and the associated social changes in terms of state-led gentrification. While such a classification may serve critical inquiry, we argue that the use of the concept may also entail certain assumptions regarding the future of these areas: their eventual demise as diverse areas with sex-related economic activities. Through a qualitative study of long-term residents, visitors and entrepreneurs in Soho, London and De Wallen, Amsterdam, we highlight how different changes are experienced depending on a person’s positioning. We also identify how locals exert some control over how these processes play out. The outcome, for the time being, has been a continuation of red light activities, albeit modified and adapted to the preferences of new residents, visitors, large investors and the state. For these reasons, we argue that the process and its outcomes should be understood as a distinct mode of neighbourhood change, namely ‘red light gentrification’. Our conceptualisation of gentrification as a locally embedded process demonstrates that the outcomes of state and market pressures are more contingent on local context than ideal-typical or policy-based understandings allow.
Maturity and Well-Being: The Development of Self-Authorship, Eudaimonic Motives, Age, and Subjective Well-Being
Authors: Bauger Lars , Bongaardt Rob , Bauer Jack J. 
Published: June 2020

AbstractIn this article, we investigate psychological maturity and other eudaimonic phenomena to predict subjective well-being (SWB), as well as if age moderate the relationship between psychological maturity and SWB. To assess psychological maturity, we analyzed 223 participants’ narratives of a high point in their life, according to Kegan’s (In over our heads: the mental demands of modern life, Harvard University Press, Cambridge, MA, 1994) theory of adult development and the accompanying subject-object interview guide. In a multiple regression analysis, we found support for our first hypothesis that level of psychological maturity in the narratives significantly predicts SWB when controlling for other eudaimonic phenomena like meaning in life, growth motivation, and authenticity. We found some support for our second hypothesis that age moderated the relation between psychological maturity and SWB, but not in the expected direction. That is, maturity predicted SWB only for those under 60 years old and not for the older age group, but this moderating influence of age on the relation between psychological maturity and SWB was not supported in regression models with a continuous or tripartite age variable. These are novel results as psychological maturity has traditionally not been associated with well-being. We discuss our findings in relation to similar constructs such as autonomy that have traditionally been linked with SWB.
Transparent conductive organic–inorganic hybrid composites based on Ag nanowires
Authors: Lang Katharina , Klein Matthias , Domann Gerhard , Löbmann Peer 
Published: June 2020

Abstract
Silver nanowires (AgNW) were incorporated into different organic–inorganic hybrids and a silicone composition that served as a reference. Spin coating yielded transparent conductive films, their respective nanowire distribution, thermal activation, and visual transparency were characterized. The percolation threshold of the films scales with the individual average AgNW length. Substantial conductivity was maintained throughout mechanical stretching up to 30%. Microstructured organic–inorganic hybrid composite films were obtained by UV lithography.
Optimal damping coefficient for a class of continuous contact models
Authors: Poursina Mohammad , Nikravesh Parviz E. 
Published: June 2020

AbstractIn this study, we develop an analytical formula to approximate the damping coefficient as a function of the coefficient of restitution for a class of continuous contact models. The contact force is generated by a logical point-to-point force element consisting of a linear damper connected in parallel to a spring with Hertz force–penetration characteristic, while the exponent of deformation of the Hertz spring can vary between one and two. In this nonlinear model, it is assumed that the bodies start to separate when the contact force becomes zero. After separation, either the restitution continues or a permanent penetration is achieved. Therefore, this model is capable of addressing a wide range of impact problems. Herein, we apply an optimization strategy on the solution of the equations governing the dynamics of the penetration, ensuring that the desired restitution is reproduced at the time of separation. Furthermore, based on the results of the optimization process along with analytical investigations, the resulting optimal damping coefficient is analytically expressed at the time of impact in terms of system properties such as the effective mass, penetration velocity just before the impact, coefficient of restitution, and the characteristics of the Hertz spring model.
A public unified bug dataset for java and its assessment regarding metrics and bug prediction
Authors: Ferenc Rudolf , Tóth Zoltán , Ladányi Gergely , Siket István , Gyimóthy Tibor 
Published: June 2020

AbstractBug datasets have been created and used by many researchers to build and validate novel bug prediction models. In this work, our aim is to collect existing public source code metric-based bug datasets and unify their contents. Furthermore, we wish to assess the plethora of collected metrics and the capabilities of the unified bug dataset in bug prediction. We considered 5 public datasets and we downloaded the corresponding source code for each system in the datasets and performed source code analysis to obtain a common set of source code metrics. This way, we produced a unified bug dataset at class and file level as well. We investigated the diversion of metric definitions and values of the different bug datasets. Finally, we used a decision tree algorithm to show the capabilities of the dataset in bug prediction. We found that there are statistically significant differences in the values of the original and the newly calculated metrics; furthermore, notations and definitions can severely differ. We compared the bug prediction capabilities of the original and the extended metric suites (within-project learning). Afterwards, we merged all classes (and files) into one large dataset which consists of 47,618 elements (43,744 for files) and we evaluated the bug prediction model build on this large dataset as well. Finally, we also investigated cross-project capabilities of the bug prediction models and datasets. We made the unified dataset publicly available for everyone. By using a public unified dataset as an input for different bug prediction related investigations, researchers can make their studies reproducible, thus able to be validated and verified.