bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological and Physical Properties of a Modification Silicone Liner
Authors: Gu Huiru , Luan Huiqin , Mo Zhongjun , Song iang , Fan Yubo 
Published: March 2020

Abstract
Silicone liners provide comfortability for amputees, meanwhile effectively protecting their skin surface and subcutaneous tissue. Silicone liners used in prosthetics are mainly used for filling, cushioning, and suspending a receiving cavity. At present, biological and mechanical properties of silicone liners in prosthetic cavity remain unclear, and the price is expensive for amputees. We improve the silicone material preparation process to reduce the price as well as to ensure the mechanics and biosafety of the material. Characterization of silicone liner surface, cellular toxicity of silicone liner, bacterial adhesion on the surface of silicone liner, and mechanical properties were evaluated and compared among commercial materials (sample A and B) and our improved silicone liner material (sample C). The water contact, the macroscopic surface and the calculated mechanical parameters have no significant differences among the three types samples. The extract of three types silicone liner have no cytotoxicity reactivity. Samples C markedly reduced the adhesion of E. coli compared with sample A. The improved silicone material preparation process ensured the biological and mechanical properties and reduced the price of these silicone liners, thereby increasing their potential as silicone liners of prosthetics cavity.
TiO2/Cu Composite NPs Coated Polyester Fabric for the Enhancement of Antibacterial Durability
Authors: Salvia Binte Touhid S , Shawon Md. Rashidul Kabir , Ali Khoso Nazakat , Xu Qingbo , Pan Dopan , Liu Xiangdong 
Published: March 2020

Abstract
Copper nanoparticles (Cu NPs) were synthesized on a plasma treated polyester fabric having a coating of TiO2 NPs. The fabric was treated with cold O2 plasma first to enhance the surface affinity for TiO2 NPs, then coated with TiO2 NPs via a heat pressing, and finally synthesize Cu NPs on the complex surface using a dip-coating process. The resulting fabric shows an excellent antibacterial effect and outstanding laundering durability, as it has satisfactory bacterial reduction performance against S. aureus and E. coli higher than 98% and behaves stable even after 50 washing cycles. This methodology for preparing antibacterial polyester fabric maybe of high potential applications in cosmetic and medical textiles.
Study on Influence of Dispersants on Stability, Thermal Conductivity and Viscosity of BN/EG Nanofluids
Authors: Li Yanjiao , Qin Zhongbao , Zou Zijie , Hou Li’an 
Published: March 2020

Abstract
Boron nitride/ethylene alcohol (BN/EG) nanofluids was synthesized by two-step method. The influence of dispersant on stability, thermal conductivity and viscosity was studied. The experimental results reveal that the stability of BN/EG nanofluids deteriorates rapidly with the addition of anionic dispersants and cationic dispersants, which has no practical application value. While, non-ionic dispersant can improve the stability and fluidity obviously and maintain the enhancement of thermal conductivity at the same time.
Study the Mechanisms of Enhanced Phonon Bottleneck Effect for the Absorber of Hot Carrier Solar Cell in III-V Multiple Quantum Wells
Authors: Zhang Yi , Huang Chao 
Published: March 2020

Abstract
The most vital key to realize hot carrier solar cell is reducing carrier relaxation time to nanoseconds by phonon bottleneck effect often observed in nanostructure. However, the mechanisms underlying this are still not well understood. In this paper, we systematically investigated the mechanisms of phonon interfacial mismatch and carrier quantum confinement over phonon bottleneck effect in InN/InxGa(1-x)N multiple quantum wells (MQWs). Highly promising hot carrier lifetimes due to enhanced phonon bottleneck effect were observed in these MQWs, where the longest hot carrier lifetime is 3.2±0.12 ns. It was found the quantum confinement of carriers could play more important role in the reduction of carrier cooling rate, while the optical phonon confinement is more likely to dominate the initial carrier temperature. This study clarifies two of the most important mechanisms of phonon bottleneck effect and directs a promising application of III-V MQWs on the absorber of hot carrier solar cell.
Influence of the Li/TM Ratio on Electrochemical Properties of LiNi0.9Co0.1O2 Cathodes
Authors: Li Danhua , Wang Jing , Wang Ran , Hou Rui , Su Yuefeng , Yuan Qiang , Chen Shi , Wu Feng 
Published: March 2020

Abstract
The layered Nickel-rich LiNixMyO2 (Ni ≥60%) cathodes have attracted much attention owing to their high energy density, promising cycle property and low cost. Nevertheless, their electrochemical performances greatly depend on the synthesis conditions, especially for the ratio of lithium to transition metal (Li / TM). Herein, we have systematically investigated the influence of Li/TM on structure and electrochemical performance of LiNi0.9Co0.1O2 cathodes. The optimized LiNi0.9Co0.1O2 (Li/TM is 1.02) exhibits highest initial capacity of 189.8mAh g−1 at 1 C and much better capacity retention of 82.19% after 100 cycles between 2.8 and 4.35 V at 1 C.
Research on Teaching Reform of Civil Engineering Materials Based on Individuation and Interactivity
Authors: Pan Chonggen , Chen Keyu , Shen Xinyuan , Liu Wei 
Published: March 2020

Abstract
Teachers should take the initiative to develop specialties of students and drive the progress of the curriculum. The traditional course of civil engineering materials has some obvious problems such as redundant course content, unreasonable scoring assessment mechanism, and low output of post-class practice. As a result, students in the classroom are less motivated and do not get insight into the understanding of this course. To conquer these limitations, this paper aims to optimize the traditional teaching system from three aspects: (1) the teaching method of course teaching, (2) the course evaluation system and (3) the extracurricular practice output. In addition, it also helps to carry out teaching activities for students based on the perspective of individuality and interaction as well as cultivate applied talents. This paper also provides a reference for the innovative teaching model.
Carrier-Induced Degradation in Monocrystalline Silicon: Dependence on the Temperature and Irradiance
Authors: Li Hailing , Wang Xinxin , Wang Wenjing 
Published: March 2020

Abstract
The dependence of the carrier-induced degradation on the temperature and irradiance is studied. The stability of samples after accelerated degradation and regeneration at different temperature and irradiance are studied also. Minority carrier lifetime and normalized defect density are used to characterize the degradation and regeneration kinetics. The mechanism of temperature and irradiance on degradation is studied and discussed.
Prioritizing genetic variants in GWAS with lasso using permutation-assisted tuning
Authors: Yang Songshan , Wen Jiawei , Eckert Scott T , Wang Yaqun , Liu Dajiang J , Wu Rongling , Li Runze , Zhan Xiang 
Published: March 2020

AbstractMotivationLarge scale genome-wide association studies (GWAS) have resulted in the identification of a wide range of genetic variants related to a host of complex traits and disorders. Despite their success, the individual single-nucleotide polymorphism (SNP) analysis approach adopted in most current GWAS can be limited in that it is usually biologically simple to elucidate a comprehensive genetic architecture of phenotypes and statistically underpowered due to heavy multiple-testing correction burden. On the other hand, multiple-SNP analyses (e.g. gene-based or region-based SNP-set analysis) are usually more powerful to examine the joint effects of a set of SNPs on the phenotype of interest. However, current multiple-SNP approaches can only draw an overall conclusion at the SNP-set level and does not directly inform which SNPs in the SNP-set are driving the overall genotype–phenotype association.ResultsIn this article, we propose a new permutation-assisted tuning procedure in lasso (plasso) to identify phenotype-associated SNPs in a joint multiple-SNP regression model in GWAS. The tuning parameter of lasso determines the amount of shrinkage and is essential to the performance of variable selection. In the proposed plasso procedure, we first generate permutations as pseudo-SNPs that are not associated with the phenotype. Then, the lasso tuning parameter is delicately chosen to separate true signal SNPs and non-informative pseudo-SNPs. We illustrate plasso using simulations to demonstrate its superior performance over existing methods, and application of plasso to a real GWAS dataset gains new additional insights into the genetic control of complex traits.Availability and implementationR codes to implement the proposed methodology is available at https://github.com/xyz5074/plasso.Supplementary informationSupplementary data are available at Bioinformatics online.
Non-insulin therapies in addition to insulin in Type 1 DM treatment
Authors: Llano Andrea , McKay Gerard A 
Published: March 2020

Abstract

Introduction
Complications of Type 1 diabetes (T1DM) remain prevalent due to suboptimal glycaemic control despite advances in analogue insulin, its delivery and technological advances in glucose monitoring. Intensive insulin therapy is associated with hypoglycaemia and weight gain. Non–insulin-dependent glucose lowering strategies may provide a strategy in improving glycaemic control without hypoglycaemia and weight gain.

Sources of data
Research papers and reviews about adjunctive treatment with insulin in T1DM in the published literature.

Areas of agreement
Non–insulin-dependent strategies may be beneficial inT1DM particularly when there is insulin resistance, but the evidence for benefit at the current time is limited. Although there have been trials with various drugs as adjunctive therapy to insulin in T1DM currently in the UK, there is only one sodium glucose transport protein 2 (SGLT2) inhibitor with a marketing authorization for use in this indication.

Areas of controversy
Potential for harm with SGLT2 inhibitors in T1DM is a potential issue, particularly euglycaemic diabetic ketoacidosis. Clinical trials confirm that there is a risk albeit small, but emerging safety data have led to questions as to whether the risk of euglycaemic diabetic ketoacidosis is higher with the use of SGLT2 inhibitors in clinical practice.

Growing points
Patient education is paramount—the work being done in T1DM to ensure safe use of SGLT2 inhibitors may help improve safety in the prescribing of SGLT2 inhibitors in Type 2 diabetes.

Areas timely for developing research
There is a need for larger clinical trials with SGLT2 inhibitors in T1DM and real world studies to clarify safety.
Structural Limits to the De-Westernization of the Communication Field: The Editorial Board in Clarivate's JCR System
Authors: de Albuquerque Afonso , de Oliveira Thaiane Moreira , dos Santos Junior Marcelo Alves , de Albuquerque Sofia Oliveira Firmo 
Published: March 2020

AbstractSince the 2000s, calls for de-Westernizing the international communication research have been common, but their practical result has been very modest, as the share of non-western countries remained minimal. This article explores the hypothesis that structural factors hamper the diversity in international media research, based on the analysis of the membership of journals listed in Clarivate's Journal of Citation Reports. The data demonstrate a strong unbalance in favor of the US -- and a particular group of US universities in special -- to the detriment of the non-Western countries. The article discusses these findings in reference to the emergence of academic capitalism and the global rankings logic, which is based on ``universal'' defined from a US (and secondarily Anglophonic) viewpoint. The JCR system plays an important role in this schema, as it artificially introduces scarcity in the international publishing system and, therefore, concentrates symbolic power in the hands of a few.
Health and well-being for all: an approach to accelerating progress to achieve the Sustainable Development Goals (SDGs) in countries in the WHO European Region
Authors: Menne Bettina , Aragon de Leon Emilia , Bekker Marleen , Mirzikashvili Nino , Morton Stephen , Shriwise Amanda , Tomson Göran , Vracko Pia , Wippel Christoph 
Published: March 2020

Abstract

Background
Forty-three out of 53 of the WHO European Member States have set up political and institutional mechanisms to implement the United Nations (UN) 2030 Agenda for Sustainable Development. This includes governance and institutional mechanisms, engaging stakeholders, identifying targets and indicators, setting governmental and sectoral priorities for action and reporting progress regularly. Still, growing evidence suggests that there is room for advancing implementation of some of the Sustainable Development Goals (SDGs) and targets at a higher pace in the WHO European Region. This article proposes the E4A approach to support WHO European Member States in their efforts to achieve the health-related SDG targets.

Methods
The E4A approach was developed through a 2-year, multi-stage process, starting with the endorsement of the SDG Roadmap by all WHO European Member States in 2017. This approach resulted from a mix of qualitative methods: a semi-structured desk review of existing committal documents and tools; in-country policy dialogs, interviews and reports; joint UN missions and discussion among multi-lateral organizations; consultation with an advisory group of academics and health policy experts across countries.

Results
The E—engage—functions as the driver and pace-maker; the 4 As—assess, align, accelerate and account—serve as building blocks composed of policies, processes, activities and interventions operating in continuous and synchronized action. Each of the building blocks is an essential part of the approach that can be applied across geographic and institutional levels.

Conclusion
While the E4A approach is being finalized, this article aims to generate debate and input to further refine and test this approach from a public health and user perspective.
System 1 Is Not Scope Insensitive: A New, Dual-Process Account of Subjective Value
Authors: Schley Dan R , de Langhe Bart , Long Andrew R 
Published: March 2020

Abstract
Companies can create value by differentiating their products and services along quantitative attributes. Existing research suggests that consumers’ tendency to rely on relatively effortless and affect-based processes reduces their sensitivity to the scope of quantitative attributes and that this explains why increments along quantitative attributes often have diminishing marginal value. The current article sheds new light on how “system 1” processes moderate the effect of quantitative product attributes on subjective value. Seven studies provide evidence that system 1 processes can produce diminishing marginal value, but also increasing marginal value, or any combination of the two, depending on the composition of the choice set. This is because system 1 processes facilitate ordinal comparisons (e.g., 256 GB is more than 128 GB, which is more than 64 GB) while system 2 processes, which are relatively more effortful and calculation based, facilitate cardinal comparisons (e.g., the difference between 256 and 128 GB is twice as large as between 128 and 64 GB).
Cancer-associated adipocyte-derived G-CSF promotes breast cancer malignancy via Stat3 signaling
Authors: Liu Li , Wu Yudong , Zhang Cheng , Zhou Chong , Li Yining , Zeng Yi , Zhang Chunbo , Li Rong , Luo Daya , Wang Lieliang , Zhang Long , Tu Shuo , Deng Huan , Luo Shiwen , Chen Ye-Guang , Xiong Xiangyang , Yan Xiaohua 
Published: March 2020

Abstract
Adipocyte is the most predominant cell type in the tumor microenvironment of breast cancer and plays a pivotal role in cancer progression, yet the underlying mechanisms and functional mediators remain elusive. We isolated primary preadipocytes from mammary fat pads of human breast cancer patients and generated mature adipocytes and cancer-associated adipocytes (CAAs) in vitro. The CAAs exhibited significantly different gene expression profiles as assessed by transcriptome sequencing. One of the highly expressed genes in CAAs is granulocyte colony-stimulating factor (G-CSF). Treatment with recombinant human G-CSF protein or stable expression of human G-CSF in triple-negative breast cancer (TNBC) cell lines enhanced epithelial–mesenchymal transition, migration, and invasion of cancer cells, by activating Stat3. Accordantly, targeting G-CSF/Stat3 signaling with G-CSF-neutralizing antibody, a chemical inhibitor, or siRNAs for Stat3 could all abrogate CAA- or G-CSF-induced migration and invasion of breast cancer cells. The pro-invasive genes MMP2 and MMP9 were identified as target genes of G-CSF in TNBC cells. Furthermore, in human breast cancer tissues, elevated G-CSF expression in adipocytes is well correlated with activated Stat3 signal in cancer cells. Together, our results suggest a novel strategy to intervene with invasive breast cancers by targeting CAA-derived G-CSF.
“El Único Problema Aquí”: A Cristero Family and Workin Los Angeles, 1927–1932
Authors: Stalls Clay 
Published: March 2020

Abstract
The Venegas family letters at Loyola Marymount University present an unusual opportunity to document the work trajectories of their authors, Dolores Dávalos de Venegas and Miguel Venegas, after their exile to Los Angeles in 1927 because of the Cristero conflict in their home state of Jalisco, Mexico. Like many Mexican migrants to Los Angeles, Miguel began work in a blue-collar job, but within six months he had acquired a modest grocery store in central Los Angeles. Miguel’s middle-class business background in Jalisco provided him with the skills, worldview, and probable capital to move into business in Los Angeles.
Elevated serum IgM levels indicate poor outcome in patients with coronavirus disease 2019 pneumonia: A retrospective case-control study
Authors: Wang Zhihua , Li Huijun , Li Jingjing , Yang Chunguang , Guo Xiaolin , Hu Zhiquan , Chen Zhiqiang , Wang Shaogang , Liu Jihong 
Published: March 2020

SummaryBackgroundThe coronavirus disease 2019 (COVID-19) pneumonia outbreak began in Wuhan and pandemics tend to occur. Although SARS-CoV-2-specific immunoglobulins have been detected in serum of COVID-19 patients, their dynamics and association with outcomes have not been characterized.MethodsA total of 116 hospitalized patients with confirmed COVID-19 pneumonia and SARS-CoV-2-specific immunoglobulins tested in Tongji hospital were retrospectively investigated. Clinical, laboratory, radiological characteristics and outcomes data were compared between mild-moderate group and died group. Further, a paired case-control study was conducted where each deceased case was matched to three mild-moderate patients of similar age.FindingsAmong 116 subjects included, 101 mild-moderate patients survived and 15 cases died. SARS-CoV-2-specific IgM levels peaked in forth week after onset of COVID-19 pneumonia, while serum IgG levels increased over 8 weeks. Serum IgM levels were higher in deceased patients than mild-moderate patients (P = 0.024), but not IgG. Serum IgM levels were negatively correlated with clinical outcome, eosinophil count and albumin levels (r = −0.269, P = 0.003; r = −0.188, P = 0.043; and r = −0.198, P = 0.033, resp.). The area under the ROC curve (AUC) for IgM antibody was 0.681 (95% CI: 0.517-0.845, P = 0.024). In case-control study paired by age, serum IgM was higher in deceased patients than mild-moderate patients (P = 0.019), positively correlated with leucocyte count (r = 0.260, P = 0.045), while negatively correlated with clinical outcome and albumin levels (r = −0.337, P = 0.008; r = −0.265, P = 0.041). AUC for IgM levels was 0.704 (95% CI: 0.534-0.873, P = 0.019).InterpretationThese results indicate that dynamics of SARS-CoV-2 specific IgM and IgG antibodies was similar with that of SARS-CoV, while elevated serum IgM levels indicate poor outcome in patients with COVID-19 pneumonia.
Deficient ER Acetyl-CoA Import in Acinar Cells Leads to Chronic Pancreatitis
Authors: Cooley M. M. , Thomas D. D. H. , Deans K. , Peng Y. , Lugea A. , Pandol S. J. , Puglielli L. , Groblewski G. E. 
Published: March 2020

AbstractMaintaining endoplasmic reticulum (ER) proteostasis is essential for pancreatic acinar cell function. Under conditions of severe ER stress, activation of pathogenic unfolded protein response pathways play a central role in the development and progression of pancreatitis. A key event in this pathogenic response is a loss of the transcription factor spliced XBP1 (XBP1s) and activation of the PERK pathway. Less is known of the consequence of perturbing ER-associated post-translational protein modification during pancreatitis. Here we show that expression of the ER acetyl-CoA transporter AT-1, necessary for ER protein acetylation, lies downstream of XBP1s and is significantly downregulated during the onset of pancreatitis. Genetic deletion of AT-1 in acinar cells of adult pancreas induces chronic ER stress marked by activation of both the XBP1s and PERK pathways, leading to mild/moderate chronic pancreatitis evidenced by accumulation of intracellular trypsin, immune cell infiltration, and fibrosis, but little pancreatic degeneration. Two-day induction of acute on chronic pancreatitis in AT-1 acinar specific knockout mice results in a severe CP phenotype with pronounced pancreatic atrophy. These findings uncover a new layer of complexity of the pathological ER stress response and its impact on pancreatic disease.
The efficacy of different preprocessing steps in reducing motion-related confounds in diffusion MRI connectomics
Authors: Oldham Stuart , Arnatkevic̆iūtė Aurina , Smith Robert E. , Tiego Jeggan , Bellgrove Mark A. , Fornito Alex 
Published: March 2020

AbstractHead motion is a major confounding factor in neuroimaging studies. While numerous studies have investigated how motion impacts estimates of functional connectivity, the effects of motion on structural connectivity measured using diffusion MRI have not received the same level of attention, despite the fact that, like functional MRI, diffusion MRI relies on elaborate preprocessing pipelines that require multiple choices at each step. Here, we report a comprehensive analysis of how these choices influence motion-related contamination of structural connectivity estimates. Using a healthy adult sample (N= 252), we evaluated 240 different preprocessing pipelines, devised using plausible combinations of different choices related to explicit head motion correction, tractography propagation algorithms, track seeding methods, track termination constraints, quantitative metrics derived for each connectome edge, and parcellations. We found that an approach to motion correction that includes outlier replacement and within-slice volume correction led to a dramatic reduction in cross-subject correlations between head motion and structural connectivity strength, and that motion contamination is more severe when quantifying connectivity strength using mean tract fractional anisotropy rather than streamline count. We also show that the choice of preprocessing strategy can significantly influence subsequent inferences about network organization, with the location of network hubs varying considerably depending on the specific preprocessing steps applied. Our findings indicate that the impact of motion on structural connectivity can be successfully mitigated using recent motion-correction algorithms that include outlier replacement and within-slice motion correction.HighlightsWe assess how motion affects structural connectivity in 240 preprocessing pipelinesMotion contamination of structural connectivity depends on preprocessing choicesAdvanced motion correction tools reduce motion confoundsFA edge weighting is more susceptible to motion effects than streamline count