bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and Efficacy of Convalescent Plasma Therapy for the Management of COVID-19: A Systematic Review
Authors: Khadka Sitaram , Saleem Mohammad , Shrestha Dhan Bahadur , Budhathoki Pravash 
Published: December 2020

Introduction:
Till date, no proven therapy exists for coronavirus disease (COVID-19),
though different types of treatment modalities are being practiced around the world. Different
studies regarding Convalescent Plasma (CP) therapy from COVID-19 recovered donors have
shown favorable results with fewer adverse consequences. In this systematic review, we aimed to
determine the safety and efficacy of CP as a therapy for COVID-19.

Methods and Materials:
The English language databases of PubMed, Google Scholar, and ScienceDirect
were searched up to 22 May 2020. Eligibility for inclusion, risk of bias assessment, and
data extraction from the included studies were determined and a narrative synthesis was conducted.

Results:
A total of 12 studies were selected for review. The overall risks of bias were moderate to
high. The results revealed significance in the initiation of CP therapy during the early stages of
viremia from a safety and efficacy viewpoint. The patients also received concomitant drugs and
other supportive therapies in most cases. Some cases of mortality were reported in 3 studies. Viral
loads were documented to decrease and become negative in 8 studies within 3-26 days post-transfusion.
The improvement in clinical symptoms following CP therapy was demonstrated in 9 studies.
Most of the patients experienced very few adverse effects.

Conclusions:
The rational practice of CP therapy based on a risk-benefit judgment can prove to be
an efficacious therapeutic option as a last resort until the approval of any therapeutic and/or prophylactic
agent(s). The substantial randomized controlled trials (RCTs) are necessary to validate the effectiveness
of such therapy.
PELIYANAN TERHADAP PEREMPUAN DUNIA KETIGA PADA RUANG SEKSUAL DALAM NOVEL PLATEFORME KARYA MICHEL HOUELLEBECQ
Authors: Taqiyya Kafana Fityah Kayla , Udasmoro Wening , Firmonasari Aprilia 
Published: December 2020

Peliyanan merupakan salah satu permasalahan yang kerap muncul di dalam sebuah novel. Pada novel Prancis berjudul Plateforme karya Michel Houellebecq, peliyanan tidak hanya terjadi di ruang publik seperti pada umumnya, namun juga pada ruang privat, yakni ruang seksual. Artikel ini bertujuan untuk mendeskripsikan dan membahas bentuk-bentuk peliyanan pada ruang seksual yang terjadi di dalam novel Plateforme sehingga memisahkan Dunia Pertama dengan Dunia Ketiga. Penelitian ini menggunakan metode analisis isi cerita. Aspek-aspek isi cerita yang dilihat difokuskan pada aspek-aspek peliyanan yang terdapat di dalam novel. Cara koleksi data dilakukan dengan menyeleksi kata, kalimat dan paragraf yang memuat aspek peliyanan tersebut. Data dimasukkan di dalam tabel data yang berisi aspek peliyanan secara umum. Data pada tabel data pertama yang terkumpul selanjutnya diidentifikasi dan dikategorisasi sesuai dengan bentuk peliyanannya masing-masing. Data yang telah dikategorisasi tersebut kemudian dianalisis dengan didialogkan dengan konsep subaltern dari Gayatri C. Spivak. Analisis terhadap data menghasilkan temuan bahwa terjadi tiga bentuk peliyanan pada ruang seksual di dalam novel Plateforme. Tiga bentuk tersebut adalah pertama objektivikasi terhadap perempuan, kedua adalah pembungkaman suara perempuan dan ketiga adalah eksploitasi terhadap tubuh perempuan Dunia Ketiga. Kata Kunci: Peliyanan, Subaltern, Ruang Seksual, Pascakolonial THE OTHERING TO THIRD WORLD WOMWEN IN SEXUAL SPACE IN PLATEFORME NOVEL’S BY MICHEL HOUELLEBECQAbstractOne of the most issues addressed in a novel is othering. In a French novel titled Plateforme by Michel Houellebecq, othering is not only happening in the public space, but also in the very private space, the sexual or intimate space. This article attempts to describe and reveal the forms of othering in the sexual space of Plateforme that separates the First World from the Third World. This research uses the story content analysis as a method. The aspects of the stories are focussed on the othering process in the novel. The data are collected from the novel based on the wordings, sentences and paragraphes containing the othering aspects. The date are listed in the table that contains general aspects of othering process. The data collected are then categorized according to each form of othering. The categorized data are then analyzed using the subaltern theory of Gayatri C. Spivak. The result reveals three forms of othering in Plateforme. Those three forms of othering are objectification, silencing attempt through representation and the exploitation of Third World women’s body. Keywords: Othering, Subaltern, Sexual Space, Postcolonialism
Using General-purpose Sentiment Lexicons for Suicide Risk Assessment in Electronic Health Records: Corpus-Based Analysis
Authors: Bittar André , Velupillai Sumithra , Roberts Angus , Dutta Rina 
Published: December 2020

Background
Suicide is a serious public health issue, accounting for 1.4% of all deaths worldwide. Current risk assessment tools are reported as performing little better than chance in predicting suicide. New methods for studying dynamic features in electronic health records (EHRs) are being increasingly explored. One avenue of research involves using sentiment analysis to examine clinicians’ subjective judgments when reporting on patients. Several recent studies have used general-purpose sentiment analysis tools to automatically identify negative and positive words within EHRs to test correlations between sentiment extracted from the texts and specific medical outcomes (eg, risk of suicide or in-hospital mortality). However, little attention has been paid to analyzing the specific words identified by general-purpose sentiment lexicons when applied to EHR corpora.

Objective
This study aims to quantitatively and qualitatively evaluate the coverage of six general-purpose sentiment lexicons against a corpus of EHR texts to ascertain the extent to which such lexical resources are fit for use in suicide risk assessment.

Methods
The data for this study were a corpus of 198,451 EHR texts made up of two subcorpora drawn from a 1:4 case-control study comparing clinical notes written over the period leading up to a suicide attempt (cases, n=2913) with those not preceding such an attempt (controls, n=14,727). We calculated word frequency distributions within each subcorpus to identify representative keywords for both the case and control subcorpora. We quantified the relative coverage of the 6 lexicons with respect to this list of representative keywords in terms of weighted precision, recall, and F score.

Results
The six lexicons achieved reasonable precision (0.53-0.68) but very low recall (0.04-0.36). Many of the most representative keywords in the suicide-related (case) subcorpus were not identified by any of the lexicons. The sentiment-bearing status of these keywords for this use case is thus doubtful.

Conclusions
Our findings indicate that these 6 sentiment lexicons are not optimal for use in suicide risk assessment. We propose a set of guidelines for the creation of more suitable lexical resources for distinguishing suicide-related from non–suicide-related EHR texts.
Balaguer al desnudo en el cuento El oidor, de Efraím Castillo
Authors: García Polanco Patricio 
Published: December 2020

El presente trabajo constituye un estudio del cuento El oidor de Efraím Castillo, en el que, a través del análisis crítico y la revisión bibliográfica, se pretende establecer la estrecha relación que hay entre el personaje literario que lo protagoniza (el oidor) y el personaje histórico que lo inspiró (Joaquín Balaguer). Recurriendo a datos históricos, así como a otros textos literarios y críticos, se compara la personalidad del ente del relato con el ser concreto que vivió y ejerció la actividad política, y se subraya el acierto del autor al recrear rasgos típicos de la personalidad del caudillo. El trabajo destaca que tanto en la realidad social como en la ficción de Castillo el personaje sobresale por uno de sus rasgos más característicos: la no aceptación de la disidencia, de ahí que la intolerancia constituya uno de los comportamientos típicos en el accionar del oidor (personaje ficcional) y de Joaquín Balaguer (personaje real). Al final, como resultado de esas comparaciones, se concluye que, efectivamente, hay un vínculo directo, identificable, entre el personaje textual, el oidor, y la persona real que lo inspira, el caudillo político y escritor Joaquín Balaguer.
El humor en los dominicanos como pretexto del trauma cultural de la colonización
Authors: Liranzo Patricia 
Published: December 2020

En este articulo de reflexión se plantea que el humor en los dominicanos se ha convertido en una defensa patológica que permanece como una barrera que impide integrar las experiencias traumáticas, como fue la colonización. El enfoque es cualitativo con un diseño documental de tipo bibliográfico y argumentativo. La colonización significó un acontecimiento traumático que alteró la vida de los pueblos originarios con experiencias colectivas de abuso, muertes, malos tratos, trabajo forzado, hambrunas, epidemias, guerras, suicidios, un sistema esclavista despiadado y la pérdida cultural. La colonización se manifiesta como una herida enmascarada del trauma cultural que se afronta desde lo inconsciente a través de la figura del Trickster personaje universal que representa lo cómico. El Trickster dominicano, como figura daimónica, se polariza en la sombra, convirtiéndose en persecutor por medio del humor agresivo, que se manifiesta como una defensa inconsciente que pretende menospreciar y ridiculizar al otro. Este humor agresivo, espasmódico y seco es una forma de control compulsivo que se conoce como relajo. Es un Trickster que expresa la invisibilización de los grupos originarios, la desdicha de la herencia española, la tristeza del negro esclavo y todo el sufrimiento a posteriori de la colonización en una mezcla racial y cultural parcialmente incorporada. El relajo del dominicano es una defensa inconsciente, que mantiene la estructura del trauma, por tanto, la fragmentación polarizada del self individual y colectivo, que no se integra a la vida consciente por lo tanto perdura como una continua disculpa del trauma histórico y cultural de la colonización.
Would an Improved Information Environment of a Less Regulated OTC Market Benefit Blue-Chip Foreign Firms? Evidence from the OTCQX International Market
Authors: Kim Martin M. , Lin Steve , Yang Liu (Leo) 
Published: December 2020

ABSTRACT
This study examines whether an improved information environment in the OTCQX International market (hereafter QX market) benefits blue-chip foreign private issuers (FPIs). We find that around 600 FPIs traded their stocks in the QX market during 2007–2016, and they are financially better than their home-country counterparts. We also find approximately 6 percent abnormal return around the cross-listing days. Moreover, FPIs with higher financial reporting transparency (i.e., lower earnings smoothness and preparing financial statements in accordance with International Financial Reporting Standards) experience more pronounced abnormal returns and liquidity improvement around cross-listing. Further analysis shows the market premium of cross-listing on the QX market is not attributed to the bonding effect. Our results highlight the importance of the information environment of a less regulated OTC market in benefiting large and established FPIs, which should be of interest to regulators, investors, and foreign firms intended to access less regulated U.S. markets.
Neurological Manifestations of Systemic Lupus Erytematosus
Authors: F. J. Hernández Ramos, , F. J. Hernández Chamorro, , M. Medina Rodríguez, , A. Palomino García, , M.D. Jiménez Hernández, 
Published: December 2020

Systemic lupus erythematosus (SLE) is the prototype of autoimmune disease with multisystemic damage capacity. Its diagnosis is based on clinical and immune criteria, which have been recently updated by EULAR/ACR, making positive antinuclear antibodies (ANA) a necessary part of the diagnosis criteria. Those criteria are responsible for the decrease in the neurological manifestations, in comparison with the former criteria.
Eighty seven LES patient’s retrospective hospital sample. Sociodemographic variables, autoimmune family history, years of evolution, diagnosis, antibodies, neurological clinic, image tests, electroencephalography and cerebrospinal fluid, treatment and obtained score according to EULAR/ACR criteria are being analysed.
Seventy patients and seventeen with other diagnosis are obtained, where 84.3% are women with an average age of 44.64 years, no autoimmune family history in 54.70% of the cases, an average of 15.3 years of evolution, 100% of ANA and 75% antiDNA positives. Headache, seizures, strokes and cognitive impairment are the most common neurological manifestations. 78.6% of them lack an image test, where steroids are the most used immunosuppressor (58.24%), followed by hydroxychloroquine (48.6%).
The frequency of the discussed neurological manifestations is similar to the one present in current literature, having cognitive decline a low prevalence. Our sample’s neurological manifestations lack of statistical significance for SLE diagnosis, being anti-DNA antibodies are crucial for it. We suggest that a prospective study with less years of evolution, widening the neurological manifestations and having anti-DNA antibodies as entry criterion, can increase statistical significance.
Iron deficiency anemia – new possibilities of iron supplementation in various clinical conditions
Authors: Michalak Sylwia Sulimiera 
Published: December 2020

AbstractIron deficiency anemia (IDA) treatment is done to eliminate the causes of iron deficiency, iron supplementation, and rarely red blood cell transfusion. Divalent iron salts are the first line of oral treatment, but their use lead to frequent gastrointestinal adverse reactions. Iron is administered intravenously in the event of contraindications, intolerance, or inefficiency of oral therapy, but the parenteral route of drug delivery is not easily accepted by the patients. Intravenous preparations for single administration of a large dose of iron have a good therapy safety profile, but are more expensive than oral and are usually administered in a hospital setting. The availability of new iron compounds: sucrosomial iron, ferric citrate complexes, and ferric maltol widen the possibilities of IDA therapy and enable the better selection of iron preparations in various clinical situations. The innovative structure of sucrosomial iron leads to absorption in different ways (through endocytosis, the paracellular pathway, M cells of Peyer's patches), ensures high bioavailability, and good tolerance of therapy. Ferric citrate, in addition to iron supplementation, reduces phosphate levels, and is beneficial to chronic kidney disease. Ferric maltol is currently being studied for IDA treatment with various comorbidities. Some studies indicate that new iron formulas may be used where intravenous intake has been recommended so far. So, we can expect treatment with iron nanoparticles and drugs that affect the intestinal microflora in the future. The paper presents current knowledge about new iron preparations that are already available in everyday practice, but also those that are at various stages of pre-clinical and clinical studies.
First familial cases of type 2 congenital erythrocytosis (ECYT2) with a Chuvash pathogenic variant in VHL gene in Poland: example of the clinical utility of next-generation sequencing in diagnostics of orphan diseases
Authors: Pepek Monika , Bal Wioletta , Radwanska Monika , Machnicki Marcin M. , Kurkowiak Malgorzata , Rydzanicz Malgorzata , Pollak Agnieszka , Stawinski Piotr , Ploski Rafal , Chaber Radoslaw , Stoklosa Tomasz 
Published: December 2020

AbstractIn this article, we report familial cases of type 2 congenital erythrocytosis (ECYT2) in two siblings, a 2-year-old boy and his younger sister. Both patients were diagnosed based on laboratory findings including erythrocytosis, elevated hemoglobin levels, and hematocrit. Acquired erythrocytosis was excluded based on the clinical features and genetic analysis of JAK2/CALR/MPL genes. Next-generation sequencing was employed for older brother revealing NM_000551.4: c.598C>T, p.Arg200Trp homozygous variant in the VHL gene, the similar variant was detected in the younger sibling. Sequencing analysis confirmed the VHL c.598C>T heterozygous variant in both parents. To the best of our knowledge, these are the first confirmed cases of familial erythrocytosis type 2, also known as Chuvash type, in Poland.
Eltrombopag use in chronic immune thrombocytopenia of childhood: results from nationwide therapeutic program
Authors: Richert-Przygońska Monika , Demidowicz Ewa , Bartoszewicz Natalia , Czyżewski Krzysztof , Wysocki Mariusz , Styczyński Jan 
Published: December 2020

AbstractBackgroundThrombopoietin receptor agonists have been repeatedly confirmed to be safe, efficient, and well tolerated in pediatric patients with chronic immune thrombocytopenia (cITP).Material and methodsIn this report, we present data summarizing the Polish experience of the use of eltrombopag in cITP patients, refractory to standard first-line care. Our analysis was based on clinical and epidemiological data from the Nationwide Therapeutic Program 2018–2020. Quality of the response to the eltrombopag treatment was defined according to the International Consensus Guidelines as follows: complete response (CR) defined as platelet count (PLT) ≥100 × 109/L and absence of bleeding; response (R) defined as PLT ≥30 × 109/L and at least two-fold increase in the baseline count and absence of bleeding.ResultsWe evaluated 60 patients (33 boys and 27 girls) with chronic and refractory ITP. Median age at beginning of treatment was 9.5 years. Median PLT at the first eltrombopag administration was 30 × 109/L. The median follow-up was 7 months (range, 3–22 months). After 1 week of treatment, response (R) was noted in 53.3% (95% confidence interval [CI]: 40.7%–66.0%) patients, and complete response (CR) was seen in 21.6% (95% CI: 11.2%–32.1%). We evaluated the long-term duration of the response and found that it was obtained in 84.4% (95% CI: 71.8%–97.0%) and 88.9% (95% CI: 77.0%–100%) of patients after 6 and 12 months, respectively, of eltrombopag therapy, while CR was reached, respectively, in 46.9% (95% CI: 29.6%–64.2%) and 29.6% (95% CI: 12.4%–46.9%) patients. No serious adverse events were reported.ConclusionOur data support the safety and efficacy of eltrombopag use in cITP pediatric patients.
Epidemiology and prevention strategies of SARS-CoV-2 infection in pediatric hematology and oncology centers in Poland
Authors: Styczyński Jan , Balwierz Walentyna , Wachowiak Jacek , Kałwak Krzysztof , Kazanowska Bernarda , Młynarski Wojciech , Dembowska-Bagińska Bożenna , Matysiak Michał , Krawczuk-Rybak Maryna , Adamkiewicz-Drożyńska Elżbieta , Kowalczyk Jerzy , Raciborska Anna , Urasiński Tomasz , Peregud-Pogorzelski Jarosław , Chaber Radosław , Badowska Wanda , Karolczyk Grażyna , Mizia-Malarz Agnieszka , Machnik Katarzyna , Goździk Jolanta , Wysocki Mariusz , Szczepański Tomasz 
Published: December 2020

AbstractIntroductionEpidemiological analysis of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections in pediatric hematology and oncology (PHO) and hematopoietic cell transplant (HCT) centers in a Polish nationwide study, as well as analysis of the preventive strategies in these centers.MethodsAll of the 18 PHO/HCT centers participated in eight surveys and questionnaires conducted over the first 5 months of the SARS-CoV-2/coronavirus disease 2019 (COVID-19) pandemic in Poland. Epidemiological data were collected at eight regular time points, and the strategy of preventive management was done once after 4 months of the pandemic.ResultsDuring this analyzed period, eight patients were positive for SARS-CoV-2. The estimated incidence of SARS-CoV-2 positivity in Polish PHO/HCT centers was 0.5%. After exclusion of HCT patients (with one patient being infected), the estimated incidence of SARSCoV-2 positivity was between 0.5 and 0.6%. In all but one case, the course of COVID-19 was asymptomatic or mild, and it was moderate in one case. None of them developed SARS or respiratory insufficiency, none of them required treatment in the intensive care unit (ICU), and no patient died due to SARS-CoV-2 infection. As of July 1, parents staying in the hospital together with their children were regularly tested for the virus in 13 centers. Asymptomatic healthcare personnel were regularly tested for the virus in seven centers.ConclusionsThe estimated incidence of SARS-CoV-2 infection among PHO/HCT patients is lower than in Western Europe; however, these patients cannot be regarded as a low-risk group. The low COVID-19 incidence should be interpreted as a result of strictly and continuously implemented detailed preventive measures in the PHO/HCT wards and in hospitals.
Effect of Basil Oil on the Performance of Biodiesel Fuelled Agricultural Engine
Authors: Kapilan Natesan , Reddy Rana Pratap 
Published: December 2020

Abstract
The rapidly depleting fossil fuel resources and stringent emission norms have given importance to research of alternative fuels, especially in relation to reduction of greenhouse gases and global warming. In the work presented, biodiesel was derived from honge oil, which is non-edible. The oxidation stability of honge oil biodiesel is low due to the content of unsaturated fatty acids. Therefore, basil oil was used as a natural antioxidant to this biodiesel and the effect of this additive on the engine performance was studied. The addition of basil oil to the honge oil biodiesel increases its oxidation stability thanks to free radical scavenging activities of the basil oil. A set of engine tests was carried out on the agricultural diesel engine with honge oil biodiesel with different concentrations of basil oil. The engine tests showed that the addition of basil oil with the concentration of 1,000 ppm reduces the engine exhaust emissions in contrast to diesel. Basil oil does not have any significant impact on the engine brake thermal efficiency. Based on this work, it is possible to conclude that basil oil can be used as a natural additive to honge oil biodiesel for the purposes of oxidation stability improvement and significant reduction of oxides of nitrogen (NOx) emission.
Sensory Evaluation of Pliek-U Quality Using Fuzzy-Topsis Method
Authors: Agustina Raida , Mustaqimah  , Fadhil Rahmat , Devianti  
Published: December 2020

Abstract
The purpose of this study is to apply one of the decision-making methods, namely the fuzzy-TOPSIS method, to determine the best alternative of coconut fermentation in process of making Pliek-U, which is a typical powder made of coconut and is used for traditional cooking recipes by people in Aceh Province, Indonesia. The weight of fuzzy criteria and judgments about alternative methods of coconut fermentation was used to calculate the sensory evaluation scores and Pliek-U quality ratings. It can help to determine the quality of the Pliek-U. Sensory evaluation results for the quality of Pliek-U using the fuzzy-TOPSIS method showed that the most ideal alternative of the coconut fermentation method in the process of making Pliek-U is the 10-day coconut fermentation method, because it had the highest closeness coefficient (0.7484) in contrast to the 7-day coconut fermentation method (0.5425), and 4-day coconut fermentation method (0.3291). The fuzzy-TOPSIS method utilization was beneficial for generating the sensory multi-criteria assessment calculations through weighting, so that the process of determining consumer acceptance of the product assessed became easier and faster.