bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maintaining oxidized H3 in heterochromatin is required for the oncogenic capacity of triple-negative breast cancer cells
Authors: Serra-Bardenys Gemma , Tian Tian , Blanco Enrique , Querol Jessica , Pascual-Reguant Laura , Morancho Beatriz , Escorihuela Marta , Segura-Bayona Sandra , Verde Gaetano , Cigliano Riccardo Aiese , Millanes-Romero Alba , Jerónimo Celia , Nuciforo Paolo , Simonetti Sara , Viaplana Cristina , Dienstmann Rodrigo , Saura Cristina , Peg Vicente , Stracker Travis , Arribas Joaquín , Villanueva Josep , Di Croce Luciano , de Herreros Antonio García , Peiró Sandra 
Published: January 2020

SUMMARYThe histone modification of H3 oxidized at lysine 4 (H3K4ox) is catalyzed by lysyl oxidase–like 2 (LOXL2) and is enriched in heterochromatin in triple-negative breast cancer (TNBC) cells. Although H3K4ox has been linked to the maintenance of compacted chromatin, the molecular mechanism underlying this maintenance is unknown. Here we show that H3K4ox is read by the CRL4B complex, leading to the ubiquitination of histone H2A through the E3 ligase RBX1. Finally, interactions between RUVBL1/2 and LOXL2 are involved in the incorporation of the histone variant H2A.Z, which plays an essential role in the mechanism controlling the dynamics of oxidized H3. Maintenance of H3K4ox in chromatin is essential for heterochromatin properties, and disruption of any of the members involved in this pathway blocks the oncogenic properties of TNBC cells.
The gut microbiota limits Th2 immunity toHeligmosomoides polygyrus bakeriinfection
Authors: Russell Gabriel A. , Faubert Cynthia , Verdu Elena F. , King Irah L. 
Published: January 2020

ABSTRACTHelminth-induced alterations to the gut microbiota have been shown to affect immune responses at local and peripheral sites. Studies examining helminth-microbiota interactions, however, have been limited due to the practical constraints of performing germ-free experiments with parasites that thrive in microbial-rich conditions to complete their development. The infectious (L3) larvae of the murine helminthHeligmosomoides polygyrus bakeri(Hpb), for example, are normally reared using a fecal-culture method and therefore are inherently unsuitable for germ-free studiesin vivo. Herein, we detail an adapted methodology for rearing effectively germ-freeHpblarvae that are able to maintain the axenic status of a germ-free host during infection. We validate that these larvae do not display any fitness defects relative to fecal-grown larvae and evoke a comparable immune responsein vivo. Characterization of axenicHpbinfection reveals that the commensal microbiota play a multifaceted role during infection - curbing the anti-HpbTh2 response and directing the resolution of tissue granulomas, while simultaneously promoting parasite fitness. Overall these data demonstrate a mutualistic relationship between commensal microbes, enteric helminths and the infected host.
Population variation of miRNAs and isomiRs and their impact on human immunity to infection
Authors: Rotival Maxime , Siddle Katherine J , Silvert Martin , Pothlichet Julien , Quach Hélène , Quintana-Murci Lluis 
Published: January 2020

ABSTRACTMicroRNAs (miRNAs) are key epigenetic regulators of the immune system, yet their variation and contribution to intra- and inter-population differences in immune responses is poorly characterized. Here, we generated 977 miRNA-sequencing profiles from primary monocytes, from individuals of African and European ancestry, following activation of three TLR pathways (TLR4, TLR1/2 and TLR7/8) or infection with Influenza A virus. We find that immune activation leads to important modifications in the miRNA and isomiR repertoire, particularly in response to viral challenges. These changes are, however, much weaker than those observed for protein-coding genes, suggesting stronger selective constraints on the miRNA response to stimulation. This is supported by the limited genetic control of miRNA expression variability (miR-QTLs) — and the lower occurrence of G×E interactions — in stark contrast with eQTLs that are largely context-dependent. We also detect marked differences in miRNA expression between populations, which are mostly driven by non-genetic factors. Yet, on average, miR-QTLs explain ~60% of population differences in expression of their cognate miRNAs, and, in some cases, evolve adaptively, as shown in Europeans for a miRNA-rich cluster on chromosome 14. Finally, integrating miRNA and mRNA data from the same individuals, we provide evidence that the canonical model of miRNA-driven transcript degradation has a minor impact on miRNA-mRNA correlations, which are, in our setting, mainly driven by co-transcription. Together, our results shed new light onto the factors driving miRNA and isomiR diversity at the population level, and constitute a useful resource for evaluating their role in host differences of immunity to infection.
Enhanced method for pulse skin effect calculation of cylindrical conductors
Authors: Raicevic Nebojsa B. , Aleksic Slavoljub R. , Iatcheva Ilona , Barukcic Marinko 
Published: January 2020

Purpose
This paper aims to present a new approach to the numerical solution of skin effect integral equations in cylindrical conductors. An approximate, but very simple and accurate method for calculating the current density distribution, skin-effect resistance and inductance, in pulse regime of cylindrical conductor, having a circular or rectangular cross-section, is considered. The differential evolution method is applied for minimization of error functional. Because of its application in the practice, the lightning impulse is observed. Direct and inverse fast Fourier transform is applied.

Design/methodology/approach
This method contributes to increasing of correctness and much faster convergence. As the electromagnetic field components depend on the current density derivation, the proposed method gives a very accurate solution not only for current density distribution and resistance but also for field components and for internal inductance coefficients. Distribution of current and electromagnetic field in bus-bars can be successfully determined if the proximity effect is included together with the skin effect in calculations.

Findings
The study shows the strong influence of direct lightning strikes on the distribution of electrical current in cables used in lightning protection systems. The current impulse causes an increase in the current density at all points of the cross-section of the conductor, and in particular the skin effect on the external periphery. Based on the data calculated by using the proposed method, it is possible to calculate the minimum dimensions of the conductors to prevent system failures.

Research limitations/implications
There are a number of approximations of lightning strike impulse in the literature. This is a limiting factor that affects the reliability and agreement between measured data with calculated values.

Originality/value
In contrast with other methods, the current density function is approximated by finite functional series, which automatically satisfy wave equation and existing boundary conditions. It is necessary to minimize the functional. This approach leads to a very accurate solution, even in the case when only two terms in current approximation are adopted.
How competitiveness factors propel SMEs to achieve competitive advantage?
Authors: Farhikhteh Shirzad , Kazemi Ali , Shahin Arash , Mohammad Shafiee Majid 
Published: January 2020

Purpose
This paper aims to assess the contribution of competitiveness factors in how small and medium-size enterprises (SMEs) would access competitive advantage (CA) by focussing on industry structure and devise a conceptual model thereof.

Design/methodology/approach
The enterprises from three industries consisting of knowledge-based, single-use medical device producers and construction stone cutting each with different structures were assessed. The method is qualitative and quantitative where grounded theory and exploratory factor analysis (EFA) are applied. The initial survey involves 36 deep semi-structured interviews with some of the top managers of each of the three selected industries and a questionnaire distributed among 158 individuals with 46 structured questions.

Findings
The findings indicate that the micro-competitiveness factors are more contributive in achieving CA than macro factors as follows: in knowledge-based enterprises, customer relationship management (CRM), goods/services features and knowledge management are the most important variables. As to single-use medical device production industry, the sales force, sales promotion, and CRM are the most effective factors. Regarding construction stone-cutting industry, quality of the stone, sales promotion, and advertisement play the same role. The results of the EFA indicate that the three impressive factors, including capabilities of the enterprises, strategies of the enterprises and macro factors, are the extracted factors.

Practical implications
The findings here would assist SMEs’ managers in identifying the most essential factors in accessing CA.

Originality/value
The innovation of this study is that although there exist many studies on SMEs and their CAs, this study seeks the models of CA among SMEs in industries with different structures.
Leading well is not enough
Authors: Ahmad Saima , Sohal Amrik Singh , Wolfram Cox Julie 
Published: January 2020

Purpose
While research on the influence of ethical and unethical behaviour on employee well-being abound, we still know little of how well-being is shaped under the dual positive and negative behavioural influences in the workplace. To address this limitation, this paper aims to investigate the relative effects of ethical behaviour of leadership and unethical bullying behaviour on employee well-being through the application of the conservation of resources theory.

Design/methodology/approach
This study was conducted in the context of Pakistan by seeking views of 330 employees in academic work settings.

Findings
The data analysis revealed that occurrence of unethical behaviour plays a more potent role than ethical behaviour in shaping employee well-being. These findings lend support to the conservation of resources theoretical perspective by reiterating the salience of resource loss over resource gain in shaping employee well-being.

Originality/value
This study offers a new insight into the management literature by highlighting that combating workplace bullying not only conserves employee well-being, but also allows organisations to capitalise more fully on the positive process enabled by leadership.
Evaluating the impact of research using the altmetrics approach (case study: the field of scientometrics)
Authors: Sedighi Mehri 
Published: January 2020

PurposeThis paper aims to assess the impact of research in the field of scientometrics by using the altmetrics (social media metrics) approach.Design/methodology/approachThis is an applied study which uses scientometric and altmetrics methods. The research population consists of the studies and their citations published in the two core journals (ScientometricsandJournal of Informetrics) in a period of five years (included 1,738 papers and 11,504 citations). Collecting and extracting the studies directly was carried from Springer and ScienceDirect databases. The Altmetric Explorer, a service provided by Altmetric.com, was used to collect data on studies from various sources (www.altmetric.com/). The research studies with the altmetric scores were identified (included 830 papers). The altmetric scores represent the quantity and quality of attention that the study has received on social media. The association between altmetric scores and citation indicators was investigated by using correlation tests.FindingsThe findings indicated a significant, positive and weak statistical relationship between the number of citations of the studies published in the field of scientometrics and the altmetric scores of these studies, as well as the number of readers of these studies in the two social networks (Mendeley and Citeulike) with the number of their citations. In this study, there was no statistically significant relationship between the number of citations of the studies and the number of readers on Twitter. In sum, the above findings suggest that some social networks and their indices can be representations of the impact of scientific papers, similar citations. However, owing to the weakness of the correlation coefficients, the replacement of these two categories of indicators is not recommended, but it is possible to use the altmetrics indicators as complementary scientometrics indicators in evaluating the impact of research.Originality/valueInvestigating the impact of research on social media can reflect the social impact of research and can also be useful for libraries, universities, and research organizations in planning, budgeting, and resource allocation processes.
Building gender-aware ecosystems for learning, leadership, and growth
Authors: Hughes Karen D. , Yang Te 
Published: January 2020

PurposeThe purpose of the paper is to examine processes of entrepreneurial learning and leadership development (ELLD) for women involved in growth-oriented businesses. It considers how ELLD can be supported by building gender-aware ecosystems for growth.Design/methodology/approachData are from a small-scale study of a growth accelerator program in Canada run by Alberta Women Entrepreneurs. The study uses a mixed-methods approach, drawing on interview, document, and observational data.FindingsThe study finds that three key activities – formal learning, informal learning and peer / community support – are central to women entrepreneurs’ learning and leadership development. In line with emerging scholarship, entrepreneurial learning is found to be strongly relational, with social capital playing a central role in the formation of human capital.Originality/valueThis study contributes to the understanding of the micro-foundations of growth, the processes involved in ELLD and the importance of developing gender-aware ecosystems.
A deep acting perspective generation Y hotel employees’ workplace deviance
Authors: Yu Yanping , Kim Haemi , Qu Hailin 
Published: January 2020

PurposeThis study aims to develop a measurement scale to assess generation Y China hotel employees’ workplace deviance and then investigate the effect of generation Y employees’ deep acting on workplace deviance by focusing on the mediating effect of emotional exhaustion and the moderating effect of organizational identification.Design/methodology/approachThe study first adopts a mixed-methods approach to develop the scale of generation Y hotel employees’ workplace deviance, then multiple data is collected targeting 580 hotel employees by a three-stage survey. Structural equation modeling (SEM) and a hierarchical regression analysis were used to test the hypotheses.FindingsWorkplace deviance of generation Y hotel employees in China was divided into two dimensions, aggression and neglect. Deep acting was found to be negatively related to workplace deviance, and emotional exhaustion had a mediating effect on the relationship between deep acting and workplace deviance. Organizational identification strengthened the effect of deep acting on neglect and the effect of deep acting on emotional exhaustion, whereas it did not moderate the relationship between deep acting and aggression.Originality/valueFirst, this study provides a more powerful explanatory perspective on the conservation of resources theory to explore future research by especially targeting generation Y employees. Second, this study develops the elements of workplace deviance structure of generation Y hotel employees, especially in the Chinese cultural context. Third, it explores the inherent mechanism of how and why deep acting impacts workplace deviance.
Determinants of farmers’ decision to adopt solar powered pumps
Authors: Kumar Vikas , Syan Amanjot Singh , Kaur Amanpreet , Hundal Bikramjit Singh 
Published: January 2020

Purpose
This study aims to examine the farmers’ awareness level and explores the factors, which may influence their adoption intention regarding solar powered pumps.

Design/methodology/approach
The study consist of a sample of 510 respondents selected from the rural region of Punjab (India) by using convenience sampling. Descriptive analysis, exploratory factor analysis, confirmatory factor analysis and multiple regression analysis techniques have been used for the analytical purpose.

Findings
The study reveals that dimensions such as perceived benefit, perceived compatibility and government incentives have a significant impact on intention to use solar powered pumps, whereas high investment cost and lack of awareness regarding government subsidies are the main reason for non-adoption of the same.

Research limitations/implications
The sample size has been selected on the basis of convenience sampling and has been taken from the rural area, which may affect its generalizability.

Practical implications
The present research is expected to be useful for the manufacturers, regulators, customers, commercial banks, product and service providers, and other environmental institutions.

Originality/value
The study has acknowledged various intentional factors, which influence the adoption decision of solar powered pumps. Therefore, the present study will be useful to formulate action plans to improve the environmental quality.
Crude oil price–shale oil production nexus: a predictability analysis
Authors: Olofin Sam O. , Oloko Tirimisiyu Folorunsho , Isah Kazeem O. , Ogbonna Ahamuefula Ephraim 
Published: January 2020

Purpose
The purpose of this study is to investigate the predictability of crude oil price and shale oil production, in a bid to examine the possibility of bi-directional causality.

Design/methodology/approach
The study adopts a recently developed predictability model by Westerlund and Narayan (2015), which accounts for persistence, endogeneity and heteroscedasticity. It also accounts for structural breaks in the predictive models.

Findings
The empirical results show that only a unidirectional causal relationship from crude oil price to shale oil production exists. This happens as crude oil price appears to be a good predictor of shale oil production; however, shale oil production does not serve as a good predictor for crude oil price. Accounting for structural break was found to improve the predictability and forecast accuracy of the predictive model. Our result is robust to choice of crude oil price benchmarks (West Texas Intermediate, Brent, Dubai Fateh and Refiners’ Acquisition Cost) and their denominations (real or nominal).

Research limitations/implications
The result implies that crude oil price must be considered when predicting shale oil production. Meanwhile, the non-significance of shale of production in crude oil price predictive model provides information to potential analyst, researchers and countries predicting crude oil price that failure to account for the effect of shale oil production would not have significant impact on the forecast accuracy of their models.

Originality/value
The study contributes originally to the literature on crude oil price–shale oil production in four major ways. First, it applies a recently developed predictability method by Westerlund and Narayan (2015), which is more suitable for dealing with persistence, conditional heteroscedasticity and endogeneity in the predictors. Second, it investigates existence of reverse causality between crude oil price and shale oil production. Third, it examines the variation in the response and effect of four major crude oil price benchmarks. Fourth, it considers crude oil price in both real and nominal terms.
A legacy of attention to embeddedness in gendered institutions
Authors: Hughes Karen D. , Jennings Jennifer E. 
Published: January 2020

PurposeThe purpose of in this study is to examine how scholarship on women’s entrepreneurship/gender and entrepreneurship has contributed to understandings of the embeddedness of entrepreneurial activity. The authors review studies from the past four decades (1975-2018) to assess the extent to which research has examined the embeddedness of entrepreneurial activity in two key institutions – the family and the labour market – that remain pervasively and persistently gendered.Design/methodology/approachThe authors blend a systematic quantitative analysis of scholarly publications with qualitative analysis, identifying key themes and contributions. The corpus of material comprises over 1,300 scholarly publications, including both empirical and theoretical contributions.FindingsThis analysis shows that attention to the embeddedness of entrepreneurial activity in gendered social institutions is a clear legacy of women’s entrepreneurship research. The systematic quantitative review found that over one-third (36.6 per cent) of scholarly publications examines questions of family and/or labour market embeddedness in some way. The qualitative analysis identifies a rich array of themes over the past four decades and a growing global reach of scholarship in recent years.Originality/valueThis paper contributes to knowledge about the embeddedness of entrepreneurial activity. It offers a comprehensive review of how entrepreneurship is shaped by the embedding of such activity in two predominant (and gendered) social institutions – families and labour markets. It will be of use to scholars seeking an overview of this topic and considering new research questions to pursue.
Exposing/correcting SME underperformance myths
Authors: Watson John 
Published: January 2020

PurposeThe purpose of this paper is to share with up-and-coming young researchers some of the important lessons the author has learnt on his research journey.Design/methodology/approachIn researching the performance of small and medium enterprises (SMEs) (and, in particular, female-controlled SMEs), the author was very careful to ensure, as far as practical, that appropriate control variables (such as age of business, industry and hours worked) were included in the research design.FindingsThere are two key findings that emerge from the research the author has been involved with over many years. First, the very high SME failure rate often referred to in the literature and popular press is a myth. Second, the belief that female-controlled SMEs underperform male-controlled SMEs is also a myth.Research limitations/implicationsBased on the author’s research experience, there are three key points the author would like to share with the young researchers. First, do not be afraid to question what might appear to be a generally accepted fact. Second, do not jump to a quick and what might appear to be the most obvious conclusion. Third, be aware that unintended consequences can often be associated with quick conclusions drawn from research where there has not been adequate attention paid to a study’s methodology/limitations.Originality/valueThe results from the research the author has been involved with highlight the importance of incorporating key control variables when assessing, and comparing, the performances of female- and male-controlled SMEs.