bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Global Sickness
Authors: Gowen Emily 
Published: November 2019

Abstract
This article reconsiders The Narrative of Arthur Gordon Pym in light of historical debates about both the rise of circum-Atlantic print culture and the problem of maritime disease. I argue that Poe invoked existing discourses about global disease in order to imagine print as a contagion in its own right and to address his growing anxieties about the changing literary landscape. In so doing, Poe anticipates later controversies about cheap print, textual overproduction, and unauthorized transatlantic reprinting, and exploits the tropes of maritime adventure fiction in order to comment on what he sees as a print culture in crisis.
Propuesta de modelo de un álbum coleccionable y un programa televisivo para la difusión del Patrimonio Cultural de Honduras
Authors: Ramírez Dennis 
Published: November 2019

La presente propuesta se fundamenta en el reconocimiento que la población hondureña tiene sobre el patrimonio cultural, evidenciado en las problemáticas y estrategias a implementar planteadas por los pobladores ante la situación cultural de sus regiones; las que a su vez se plasmaron en los informes de las 9 Estrategias Regionales de Cultura en Honduras, que se elaboraron en el 2011. De estos informes resultó que la problemática más coincidente, a nivel regional, fue la “desvalorización del Patrimonio Cultural” y la estrategia a implementar que más se repetía fue “La promoción y valoración de la cultura para que la población disfrute de ella”. Consecuentemente, al revisar la situación de los inventarios patrimoniales y los programas culturales de televisión en Honduras, se evidenció que los inventarios de patrimonio material edificado, están incompletos y en el caso del patrimonio inmaterial son inexistentes; por su parte los programas “culturales” que se transmiten en la televisión hondureña tienen más una orientación turística, y no de promoción y aprovechamiento del legado cultural. De esta situación planteada nace la principal premisa de ésta propuesta: “No se puede cuidar, ni mucho menos valorar, lo que no se conoce”. A partir de ello, se plantea la elaboración de un álbum coleccionable y un programa televisivo, como instrumentos de difusión del patrimonio cultural y concienciación en la sociedad para su uso responsable y adecuada conservación.
Patents and Diagnostic Methods in the U.S.: The Subject Matter Eligibility Trap
Authors: Saladich Nebot Javier 
Published: November 2019

Diagnostic methods have been gaining medical recognition and social importance as innovations that can be useful to provide individuals with a diagnosis, prognosis or prediction with regard to a condition that they currently have or that they are in risk of developing. Despite the great amount of resources deployed to produce these health technologies and their potential benefits for healthcare systems and patients or prospective patients alike, their exclusive protection in the United States has faced resistance from patent examiners and courts on the basis that diagnostics constitute a dubious innovation. Inconsistent arguments used for the refusal of patent protection have led to a labyrinth where innovators in the diagnostics sector cannot reasonably expect their application or their protection after the patent is in place to stand.
This paper aims to convey the doctrine of subject matter eligibility as applied to diagnostic methods and the relevant guidelines and case law. In doing so, it aims to depict the pitfalls resulting from the general application of a non-patentability rule to diagnostics, and to suggest opportunities still available for innovators to overcome uncertainty by filing compliant applications while maximizing the likeliness of enjoying protection once the patent is awarded.
As doenças raras na escola uma incursão pela literatura
Authors: Catana Felícia , Ribeiro Célia , Carvalho Anabela 
Published: November 2019

Ainda que do ponto de vista da prevalência sejam raras, o impacto das Doenças Raras (DR’s) é considerável, quando se verifica que, no seu conjunto, afetam uma percentagem muito significativa da população. Tendo em conta que estas doenças diminuem consideravelmente a qualidade de vida das crianças atingidas, bem como dos seus familiares, os profissionais da educação deverão estar atentos e preparados para lidar com esta realidade. Relativamente ao impacto da Doença Rara (DR) na vida escolar do aluno, o apoio a prestar beneficiaria com uma visão holística, por parte da equipa educativa, não só das dificuldades e necessidades dos alunos e suas famílias, mas também das suas potencialidades educativas. Estudos recentes preconizam uma intervenção educativa baseada na etiologia, por forma a otimizar o processo de ensino-aprendizagem junto das crianças com DR.
Determination of Antibiotic Resistance Profile and Virulence Genes in Escherichia coli Isolates from Palestinian Patients
Authors: Adwan Ghaleb 
Published: November 2019

Introduction: Escherichia coli (E. coli) is considered one of the most frequent intestinal and extraintestinal pathogen.
Methods: A total of 49 isolates of E. coli were collected from different clinical samples, from different hospitals in Northern West Bank-Palestine, during January-March 2019.
Aims: To detect the distribution of Type III secretion system (T3SS) genes, class 1, 2 and 3 integrons, virulence factors (fyuA, papGIII, iutA and sfa⁄foc) using multiplex PCR and antibiotic resistance using disc diffusion method.
Results: In this study, E. coli isolates showed high resistance rate against different types of antibiotics and 71.4% of the isolates were multidrug resistant (MDR). Only class 1 integron was detected in these isolates with prevalence 57%, and 65.7% of MDR isolates carried integron genes. The prevalence of T3SS genes was 0.0%. In addition, results of this study showed that the prevalence of virulence genes papGIII, sfa⁄foc, fyuA and iutA was 4.1%, 40%, 64%, and 79.6%, respectively.
Conclusions: The isolates of E. coli showed high resistance rate against different types of antibiotics. The co-occurrence of class 1 integrons and antimicrobial resistance genes in these isolates is an additional threat for spread of the antimicrobial resistance traits which may further complicate future strategies for treatment the infections caused by this pathogen. In addition, E. coli isolated from Palestinian patients showed one or more virulence factors that could increase their pathogenic potential.
From Simple to Architecturally Complex Hydrogel Scaffolds for Cell and Tissue Engineering Applications: Opportunities Presented by Two‐Photon Polymerization
Authors: Song Jiaxi , Michas Christos , Chen Christopher S. , White Alice E. , Grinstaff Mark W. 
Published: November 2019

AbstractDirect laser writing via two‐photon polymerization (2PP) is an emerging micro‐ and nanofabrication technique to prepare predetermined and architecturally precise hydrogel scaffolds with high resolution and spatial complexity. As such, these scaffolds are increasingly being evaluated for cell and tissue engineering applications. This article first discusses the basic principles and photoresists employed in 2PP fabrication of hydrogels, followed by an in‐depth introduction of various mechanical and biological characterization techniques used to assess the fabricated structures. The design requirements for cell and tissue related applications are then described to guide the engineering, physicochemical, and biological efforts. Three case studies in bone, cancer, and cardiac tissues are presented that illustrate the need for structured materials in the next generation of clinical applications. This paper concludes by summarizing the progress to date, identifying additional opportunities for 2PP hydrogel scaffolds, and discussing future directions for 2PP research.
Pore Engineering of 2D Mesoporous Nitrogen‐Doped Carbon on Graphene through Block Copolymer Self‐Assembly
Authors: Hou Dan , Zhang Jiacheng , Tian Hao , Li Qian , Li Chen , Mai Yiyong 
Published: November 2019

AbstractPore engineering has been recognized as a power methodology to fabricate carbon‐based catalysts with highly efficient electrocatalytic performance for oxygen reduction reaction. This paper reports an interfacial self‐assembly engineering for the growth of mesoporous N‐doped carbon with spherical or cylindrical pores on graphene nanosheets. The resulting 2D porous nanocomposites templated from Pluronic block copolymers possess similar N doping contents of ≈2.6 wt%, average pore sizes of ≈8 nm in diameter, and specific surface areas of ≈420 m2 g−1. Due to the faster in‐plane ion diffusion offered by the continuous cylindrical channels, the porous carbon nanosheets with cylindrical pores exhibit superior oxygen reduction reaction (ORR) electrocatalytic performance in 0.1 m KOH, with a half‐wave‐potential (E1/2) of +0.74 V and a limiting current density (JL) of 4.8 mA cm−2, comparable to those of the commercial Pt/C catalysts. This study sheds light on the influence of pore structure on the ORR catalytic performance of 2D carbon materials, and also provides clues for the fabrication of porous materials with tailorable pore structures for high‐performance electrocatalysts.
Functional Mid‐Infrared Polaritonics in van der Waals Crystals
Authors: Kim Seyoon , Menabde Sergey G. , Brar Victor W. , Jang Min Seok 
Published: November 2019

AbstractDespite high scientific and technological potential, nanophotonics research in the mid‐infrared regime remains relatively less explored compared to other frequency bands, largely because the mid‐infrared requires a totally different set of optical materials. Polaritons in layered 2D materials, or van der Waals (vdW) crystals, provide a new set of building blocks for mid‐infrared nanophotonics. Herein, the recently reported polaritonic properties of various vdW crystals are summarized in the context of their mid‐infrared applications. Both polaritons in vdW crystals with naturally anisotropic atomic structures as well as tunable plasmon polaritons in vdW semimetals are discussed. The extreme field confinement of 2D polaritons (confinement factors ≈100) enhances both their radiative heat transfer as well as the optical coupling to the vibrational modes of molecules, allowing for highly sensitive chemical detection. Their tunable properties, meanwhile, enable dynamic modulation of mid‐infrared light to realize dynamic phase shifters, mid‐infrared modulators, and spectrally tunable thermal emitters. By vertically stacking vdW crystals, it is possible to create a large variety of new effective materials with substantially different polaritonic properties compared to their building blocks.
Angle and Polarization Selective Spontaneous Emission in Dye‐Doped Metal/Insulator/Metal Nanocavities
Authors: Caligiuri Vincenzo , Biffi Giulia , Palei Milan , Martín‐García Beatriz , Pothuraju Renuka Devi , Bretonnière Yann , Krahne Roman 
Published: November 2019

AbstractDirecting and polarizing the emission of a fluorophore is of fundamental importance in the perspective of novel photonic sources based on emerging nanoemitter technologies. These two tasks are usually accomplished by a sophisticated and demanding structuring of the optical environment in which the emitter is immersed, or by nontrivial chemical engineering of its geometry and/or band structure. Here, the wavelength and polarization selective spontaneous emission from a dye‐embedded in a metal/insulator/metal (d‐MIM) nanocavity is demonstrated. A push–pull chromophore with large Stokes shift is embedded in a MIM cavity whose resonances are tuned with the spectral emission band of the chromophore. Angular and polarization resolved spectroscopy experiments reveal that the radiated field is reshaped according to the angular dispersion of the nanocavity, and that its spectrum manifests two bands with different polarization corresponding to the p‐ and s‐polarized resonances of the cavity. The d‐MIM cavities are a highly versatile system for polarization and wavelength division multiplexing applications at the nanoscale, as well as for near‐field focused emission and nanolenses.
Manipulating Nonclassicality via Quantum State Engineering Processes: Vacuum Filtration and Single Photon Addition
Authors: Malpani Priya , Alam Nasir , Thapliyal Kishore , Pathak Anirban , Narayanan Venkatakrishnan , Banerjee Subhashish 
Published: November 2019

AbstractThe effect of two quantum state engineering processes that can be used to burn a hole at vacuum in the photon number distribution of quantum states of radiation field is compared using various witnesses of lower‐ and higher‐order nonclassicality as well as a measure of nonclassicality. Specifically, the modification in nonclassical properties due to vacuum state filtration and a single photon addition on an even coherent state, binomial state, and Kerr state are investigated using the criteria of lower‐ and higher‐order antibunching, squeezing, and sub‐Poissonian photon statistics. Further, the amount of nonclassicality present in these engineered quantum states having enormous applications in continuous variable quantum communication is quantified and analyzed by using an linear entropy‐based entanglement potential. It is observed that all the quantum states studied here are highly nonclassical, and the hole‐burning processes can introduce/enhance nonclassical features. However, it is not true in general. A hole at vacuum implies a maximally nonclassical state (as far as Lee's nonclassical depth is concerned), but a particular process of hole burning at vacuum does not ensure the existence of any particular nonclassical feature. Specifically, lower‐ and higher‐order squeezing are not observed for photon‐added and vacuum filtered even coherent states.
Augmentation of performance properties of maleated SEBS/TPU blends through reactive blending
Authors: Anagha M. G. , Naskar Kinsuk 
Published: November 2019

ABSTRACTMeticulous investigation of reactive blending of maleic anhydride grafted styrene–ethylene–butylene–styrene (SEBS‐g‐MA) and thermoplastic polyurethane (TPU) is carried out to achieve systems with controllable morphology and superior mechanical properties. Two types of SEBS‐g‐MA (abbreviated as M1, M2) with different maleic anhydride content were used to separately blend with TPU. Formation of imide group from the interaction of isocyanate and maleic anhydride predicted from the plausible reaction scheme was confirmed through Fourier transform infrared spectroscopy. High tensile strength of the blends along with appreciable elongation at break was witnessed. Morphology analyses using scanning electron microscopy and atomic force microscopy exposed a vivid and homogenous droplet morphology in all the blends presumably due to in situ formation of a suitable copolymer at the interface. Differential scanning calorimetry was used to pursue the thermal characteristics of the blends. Melt‐rheological behavior of the blends was examined using a rubber process analyzer. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48727.
HMGA2 gene polymorphisms and Wilms tumor susceptibility in Chinese children: a four‐center case‐control study
Authors: Cheng Jiwen , Zhuo Zhenjian , Yang Liu , Zhao Pu , Zhang Jiao , Zhou Haixia , He Jing , Li Peng 
Published: November 2019

AbstractWilms tumor is a kidney malignancy that typically occurs in children. Aberrant expression of HMGA2 gene is commonly seen in many malignant tumors. Yet, HMGA2 gene polymorphisms on Wilms tumor risk are not established. We carried out the first four‐center case‐control study with 355 patients and 1,070 controls to assess the association of HMGA2 polymorphisms (rs6581658 A>G, rs8756 A>C, and rs968697 T>C) with Wilms tumor risk. All of these three polymorphisms in single could not impact Wilms tumor risk. Stratified analysis revealed a contributing Wilms tumor risk role of rs968697 TC/CC in subgroup of male (TC/CC vs. TT: adjusted odds ratio [OR] = 1.46, 95% confidence interval [CI] = 1.03–2.08, P = 0.035). However, we found that presence of 1–3 protective genotypes were less likely to develop tumor in subgroup of female (adjusted OR = 0.69, 95% CI = 0.48–0.99, P = 0.045). Our findings suggest that HMGA2 gene polymorphisms might influence Wilms tumor predisposition in a weak manner, under certain circumstances.
Low‐cost recycling production of pectinase to increase the yield and quality of Muzao jujube juice by Aspergillus niger
Authors: Yang Chun , Wang Jiahong , Chio Chonlong , Chen Xuantong , Zhang Ling , Zhang Jiangning , Feng Zhihong , Han Jiming , Ding Weiying , Qin Wensheng 
Published: November 2019

AbstractA low‐cost recycling system for the production of pectinase was built to improve the yield and quality of Muzao date juice and to reduce production costs. An Aspergillus niger strain, Gyx086, was selected from 20 A. niger strains on potato agar plates containing Muzao date residues, and the strain was used to produce an enzyme cocktail with high pectinase activity using Muzao date residues as the medium. The high pectinase activity level was therefore used in the production of Muzao date juice. Under optimized enzymatic hydrolysis conditions, a date juice yield of 92.88% was obtained, which was 11% higher than the control, and was not significantly different from a commercial preparation. Further storage trials indicated that the clarity, viscosity, storage stability, and soluble solid content could also be greatly improved by enzymatic treatment. These results suggested that the cheap experimental preparation could effectively replace the commercial preparation used for the production of date juice. This is the first systematic report detailing the production of Muzao date juice using a cheap and effective pectinase cocktail, which could promote the development of the date juice industry. © 2019 Society of Chemical Industry and John Wiley & Sons, Ltd
Remediating reduced memory specificity in bipolar disorder: A case study using a Computerized Memory Specificity Training
Authors: Martens Kris , Takano Keisuke , Barry Tom J. , Holmes Emily A. , Wyckaert Sabine , Raes Filip 
Published: November 2019

AbstractObjectivesReduced autobiographical memory specificity (rAMS) is a vulnerability factor found across unipolar depression (UD), posttraumatic stress disorder (PTSD), eating disorder, schizophrenia, and bipolar disorder (BD). A group delivered psychological therapy training called Memory Specificity Training (MeST) remediates rAMS in UD and PTSD, with additional downstream effects on related psychological processes and symptoms. Its impact in BD is unknown. In this case study, we examined the impact of a computerized version of MeST (c‐MeST) on improving AMS and related symptoms and processes in participant with rapid cycling type I BD.MethodAn experimental case study with an ABA design was used. During baseline (14 days, Phase A), the training phase (nine sessions across 17 days, Phase B), and a 1‐month follow‐up (Phase A), memory specificity, depressive symptoms, and related processes and symptoms were repeatedly measured.ResultsMemory specificity increased significantly after the participant completed c‐MeST. Session‐to‐session scores indicated that AMS improved most from the in‐person baseline assessment to the first online session. All other measures of processes and symptoms deteriorated during the training phase but regressed to baseline during follow‐up.ConclusionMemory specificity was improved as indicated by increased AMS from pre‐intervention measurement to 1‐month follow‐up. Other improvements in symptoms were not observed. Rather, some related maladaptive psychological processes and symptoms worsened during the training phase and regressed to baseline during follow‐up.
Targetable Tetrazine‐Based Dynamic Nuclear Polarization Agents for Biological Systems
Authors: Lim Byung Joon , Ackermann Bryce E. , Debelouchina Galia T. 
Published: November 2019

AbstractDynamic nuclear polarization (DNP) has shown great promise as a tool to enhance the nuclear magnetic resonance signals of proteins in the cellular environment. As sensitivity increases, the ability to select and efficiently polarize a specific macromolecule over the cellular background has become desirable. Herein, we address this need and present a tetrazine‐based DNP agent that can be targeted selectively to proteins containing the unnatural amino acid (UAA) norbornene‐lysine. This UAA can be introduced efficiently into the cellular milieu by genetic means. Our approach is bio‐orthogonal and easily adaptable to any protein of interest. We illustrate the scope of our methodology and investigate the DNP transfer mechanisms in several biological systems. Our results shed light on the complex polarization‐transfer pathways in targeted DNP and ultimately pave the way to selective DNP‐enhanced NMR spectroscopy in both bacterial and mammalian cells.
Heterotopic ossification in a 7‐year‐old female patient treated with individualized homeopathy: A case report
Authors: Tsintzas Dionysios , Jaggi Atul , Jaggi Latika , Mahesh Seema , Vithoulkas George 
Published: November 2019

AbstractClassical homeopathy can be included among the treatment options for congenital heterotopic ossification.
Carbon Nanotube‐Based Non‐Precious Metal Electrode Catalysts for Fuel Cells, Water Splitting and Zinc‐Air Batteries
Authors: Yang Jun , Ganesan Pandian , Ishihara Akimitsu , Nakashima Naotoshi 
Published: November 2019

AbstractThe design and creation of a sustainable green source of energy with a high performance is highly important. There are many approaches for this goal, and one of promising alternative energy technologies should be batteries and fuel cells. Precious metals, such as Pt and Ir, have been used as catalyst materials for fuel cells for cars and stationary power generation, water splitting, etc.; however, such metals are expensive and not earth‐abundant elements. The replacement of such precious metal‐based electrocatalysts with low‐cost materials is crucial for the next generation sustainable energy society. This minireview focuses on nanocarbons, especially carbon nanotubes, for use in the preparation of non‐precious metal catalysts for fuel cells, oxygen reduction, oxygen evolution, hydrogen evolution, water splitting and Zn‐air battery with a high performance.
Rational Construction of V2O5@rGO with Enhanced Pseudocapacitive Storage for High‐Performance Flexible Energy Storage Device
Authors: Hu Bingbing , Guo Chaozhong , Xu Chuanlan , Cen Yuan , Hu Jiahong , Li Yan , Yang Shu , Liu Yuping , Yu Danmei , Chen Changguo 
Published: November 2019

AbstractEnormous efforts have recently been devoted to exploiting high Faradaic redox active materials with ultrahigh energy density in new generation energy storage systems. In this study, a facile and cost‐effective solvothermal method was employed to synthesize high capacitance of rGO in situ encapsulating V2O5 microspheres (note as VrG). Benefiting from its unique hierarchical structure, large number of Faradaic redox active sites, and excellent electronic conductivity of rGO, the VrG composites can provide excellent pseudocapacitive performance with fast charge transfer and reaction kinetics between electrolyte and electrode material. Especially, the post‐optimized VrG‐5 demonstrates a remarkable discharge specific capacitance of 575 C g−1 at a current density of 1 A g−1 and an outstanding rate capability (48 % capacitance retention with the rate increasing 20 times), which is far better than the precursor component V2O5 under identical conditions. More importantly, the flexible VrG‐5//rGO asymmetric supercapacitors device can not only deliver excellent specific capacitance of 237 C g−1 and a high energy density of 46 Wh Kg−1, but also exhibit a superior mechanical flexibility under various bending angles and even 83 % capacitance retention after 5000 cycles under mechanical bending 180°, indicating its great potential application in the future flexible energy storage devices.