bluuebunny/crossref_metadata_2025_split huggingface dataset:
Docking Investigations Targeting Receptors 2AZ5 and 5KIR, along with the Synthesis and Pharmacological Assessment of Derivatives of 7-Hydroxy-4-Methyl Coumarin
Authors: Gupta Sakshi , Sahoo Nalini Kanta , Kaur Komalpreet , Gupta Jahanvi , Singh Anita , Pargaien Amrita Verma 
Published: December 2024

Background:
Inflammation, a crucial defense mechanism of the immune system, seeks
to safeguard and restore tissue equilibrium in response to tissue damage or infection by pathogens.
Key indicators of inflammation include redness, discomfort, swelling, warmth, and impaired
function. However, unmanaged inflammation can lead to serious health issues.

Objective:
The aim of this research work is to perform docking studies to find out the potent antiinflammatory
activity of various moieties (Schiff bases, hydrazones, and amino acid) derivatives,
which are attached to C-8 of 7-hydroxy-4-methyl coumarins. Also, the synthesized compounds
were characterized and their pharmacological evaluation (in-vitro and in-vivo study) was conducted.

Methods:
Lipinski's Rule of Five assessed drug-likeness for each designed molecule. Molecular
docking with COX-2 protein was conducted using AutoDock vina to identify the highest-scoring
molecule. Various novel coumarin derivatives, which include Schiff bases, hydrazone, and amino
acid derivatives (F, G, and H, respectively) were prepared by inserting the formyl group at the C-
8 position of 7- hydroxy-4-methyl coumarin. At first, the docking studies were performed against
2AZ5 and 5KIR receptors to find the activity against inflammation. Also, the compounds with the
best dock scores were synthesized and elucidated by FT-IR, 1H- NMR, and Mass spectroscopy.
Moreover, a series of novel derivatives were screened in in-vitro and in-vivo to evaluate the potent
anti-inflammatory activity.

Results:
All the novel derivatives, which were synthesized have been found to show potent antiinflammatory
activity by in-vitro and in-vivo evaluation. Among all the derivatives, compound F1
showed the highest inhibitory effect against TNF-α and COX-2 enzymes.

Conclusion:
Our result exhibited potential anti-inflammatory activity of the novel coumarin
compounds, especially the substituted anilines and amino acids at C8 of the coumarin moiety,
which works against TNF- α and COX-2 enzyme.
Exploring Therapeutic Potential of Hydrotropic Solid Dispersions of Hesperidin and Naringenin for the Management of Diabetes and Obesity
Authors: Arora Bhawna , Lather Viney , Pathalingappa Mallikarjuna Bandrehalli , Singh Amarjeet , Walia Ramanpreet 
Published: December 2024

Abstract:
The preclinical antidiabetic and anti-obesity potential of hydrotropic solid dispersions
of hesperidin and naringenin was investigated in streptozotocin [STZ]/nicotinamide [NIC]-induced
diabetic rats on a high-fat diet. The hydrotropic solid dispersions showed significant
glycemic control, insulin sensitivity, and lipid profiles while reducing body weight, adipose tissue
mass, and inflammatory markers. These formulations showed superior efficacy over pure compounds,
likely due to enhanced solubility compared to the pure drugs. Findings suggested that hesperidin
and naringenin hydrotropic solid dispersions are promising agents for showing antihyperglycemic,
antidyslipidemic, and cardiac function-improving potential in high-fat diet/STZ-induced
type 2 diabetic rats, supporting their potential clinical application as adjunct therapies. These findings
support the utility of the tested samples in clinical applications as an adjunct therapy.
Integrating Deep Learning and Molecular Dynamics to Identify GPR17 Ligands for Glioblastoma Therapy
Authors: Ramalakshmi Satyanarayana , Priya Selvaraj Sathya , Senthil Renganathan , Anand Thirunavukarasou , Saravanan Konda Mani 
Published: December 2024

Background:
Guanine Protein-coupled Receptor 17 (GPR17) plays pivotal roles in various
physiological processes and diseases. However, the discovery of ligands binding to GPR17 remains
an active area of research.

Methods:
In this study, we utilized our recently published GPCR-specific deep learning approach,
molecular docking, and molecular dynamics simulations. Specifically, the DeepGPCR model, employing
graph convolutional networks, was used to screen the extensive ZINC database for potential
ligands.

Results:
This computational pipeline identified three highly promising lead compounds,
ZINC000044404209, ZINC000229938097, and ZINC000005158963. Molecular dynamics simulations
confirmed the stability of the protein-ligand complexes while binding free energy calculations
highlighted the crucial molecular forces stabilizing these interactions. Notably,
ZINC000229938097 exhibited particularly favorable binding energy values among the compounds
assessed.

Conclusion:
Our study underscores the efficacy of computational methodologies in identifying potential
drug candidates targeting GPR17. Understanding the molecular mechanisms underlying
GPR17 activation holds significant promise for developing tailored therapies for Glioblastoma
Multiforme.

conclusion:
The current study highlights the utility of computational tools in drug development and provides information on GPR17 as a target for GBM treatment and the directions for further experimental testing and utilization.
Inderka residents – participants of the World War I
Authors: Abdullina Ryashidya Khamzievna 
Published: December 2024

This article is devoted to the study of participation of residents of the Tatar village Inderka of Sosnovoborskiy district of the Penza region in the World War I. The central issue is the fate of the war participants. The primary goal of the research is to trace their military and personal journeys. The article includes brief biographies of veterans.
For citation: Abdullina R.Kh. Inderka residents – participants of the World War I. From History and Culture of Peoples of the Middle Volga Region. 2024, vol.14, no.4, pp.157–163. https://doi.org/10.22378/2410-0765.2024-14-4.157-163 (In Russian)
Participation of Ural (Yaik) Cossacks in annexation of Central Asia to Russia
Authors: Dubovikov Alexander Maratovich 
Published: December 2024

The article shows the history of the participation of the Ural (until 1775 – Yaik) Cossacks in military campaigns in Central Asia and in campaigns to conquer it. Yaik Cossacks were the first Russians to make military campaigns in Central Asia. However, both of these campaigns, which took place at the very beginning of the 17th century, ended tragically for the Cossacks. During the reign of Peter I, Yaik Cossacks participated in the Khiva campaign of Bekovich-Cherkassky, but this campaign also ended with the death of the Russian detachment. For most of the 19th century, the Ural (former Yaik) Cossacks took an active part in expeditions to the territory of the Kazakh steppe, the purpose of which was to explore its territory in order to determine the optimal routes for future campaigns in Central Asia, as well as to select the sites of future steppe fortifications as intermediate points on the route and military support bases. In 1839–1840, they formed a significant (and best) part of General V.A. Perovsky's detachment, although this expedition also failed to achieve its desired goal. In the second half of the 19th century, military campaigns in Central Asia intensified sharply, and eventually this region was included in the Russian Empire. The Ural Cossack hundreds took an active part in all these military campaigns.
For citation: Dubovikov A.M. Participation of Ural (Yaik) Cossacks in annexation of Central Asia to Russia. From History and Culture of Peoples of the Middle Volga Region. 2024, vol.14, no.4, pp.64–82. https://doi.org/10.22378/2410-0765.2024-14-4.64-82 (In Russian)
Художественный концепт «Письмо» в «Повестях Белкина» А. С. Пушкина
Authors: Соловьева Е.Е. 
Published: December 2024

Художественный концепт «Письмо» в «Повестях Белкина» А. С. Пушкина играет важную роль на всех уровнях текста. Организуя непрямой диалог пишущего и получателя, письмо раскрывает характеры персонажей. В качестве мотива концепт «письмо» участвует в развитии сюжета, в том числе появляется в кульминации и развязке, а также участвует в создании повествовательной структуры повестей и показывает авторскую позицию в отношении традиций психологической прозы.
The literary concept of “Letter” in “The Belkin Tales” by A. S. Pushkin plays an important role at all levels of the text. By organizing an indirect dialogue between the writer and the recipient, the letter reveals the character personalities. As a motive, it participates in the development of the plot, including appearing in the climax and denouement. The concept of "Letter" participates in the development of the narrative structure of the stories and shows the author's position in relation to the traditions of psychological prose.
Взаимосвязь психологического благополучия подростков с особенностями их взаимоотношений с родителями
Authors: Гильяно Альбина Сергеевна , Шувалова Виктория Александровна 
Published: December 2024

Рассматривается вопрос, раскрывающий связь детско-родительских отношений и психологического благополучия подростков. Показано, что психологическое благополучие представляет собой сложный личностный конструкт, включающий в себя несколько важных факторов, влияющих на успешное или проблемное прохождение кризисного этапа в развитии. Дана характеристика психологического благополучия и его основных компонентов – автономия, самопринятие, управление средой, личностный рост, наличие цели в жизни. Приведены результаты эмпирического исследования, которое позволило определить факторы, влияющие на психологическое благополучие подростка, и определены стили родительского взаимодействия, способствующие его проявлению. Показано, что недостаточное внимание со стороны родителей, низкий уровень эмоциональной поддержки, сочетание авторитарного и индифферентного стиля руководства негативно влияют на психологическое благополучие подростка. Подростки с высоким уровнем психологического благополучия воспитываются в семьях с преобладанием авторитетного стиля взаимодействия. В качестве наиболее существенных особенностей взаимоотношений в семье, оказывающих позитивное влияние на психологическое благополучие подростка, выступают эмоциональная близость, принятие, сотрудничество, согласие, последовательность воспитания и удовлетворенность отношениями. Материалы исследования могут быть полезны психологам, работающим с семьями, воспитывающими подростков.
A question is being considered that reveals the connection between child-parental relations and the psychological well-being of teenage children. It has been shown that psychological well-being is a complex personal construct, including several important personal factors that affect the successful or problematic passage of the crisis stage in development. The description of psychological well-being and its main components are given - autonomy, self-acceptance, environmental management, personal growth, self-acceptance, the presence of a goal in life. The results of an empirical study are presented, which made it possible to determine the factors affecting the psychological well-being of an adolescent and determine the styles of parental interaction that contribute to its manifestation. It is shown that insufficient attention from parents, low levels of emotional support, a combination of authoritarian and indifferent leadership style negatively affect the psychological well-being of a teenager. Adolescents with a high level of psychological well-being are brought up in families with a predominance of an authoritative style of interaction. Additionally, it was revealed that the most significant features of family relationships that have a positive impact on the psychological well-being of a teenager are: emotional closeness, acceptance, cooperation, consent, consistency of upbringing and satisfaction with relationships. Research materials can be useful to psychologists working with families raising adolescents
Biochar and Humic Substances Roles for Nitrogen Transformation in Agriculture
Authors: Pratiwi Gagad Restu , Nurrahma Arinal Haq Izzawati 
Published: December 2024

Sustainable soil fertility management is crucial for global food security and addressing environmental challenges from modern agriculture. Soil health, alongside water availability, is essential for crop productivity, and soil degradation threatens food security by lowering yields and intensifying climate change. Nitrogen (N) cycling is central to soil fertility, supporting plant growth through nutrient replenishment and microbial activity. However, N is often lost through leaching, volatilization, and denitrification, reducing nitrogen use efficiency (NUE) and contributing to water pollution and greenhouse gas (GHG) emissions. Optimizing nitrogen retention in soils is vital for improving productivity and minimizing environmental harm. Biochar (BC) and humic substances (HSs) have emerged as effective strategies for improving N management. BC enhances soil fertility by increasing soil pH, cation exchange capacity, and water retention, while reducing nutrient leaching and promoting carbon sequestration. HSs, including humic acids (HA), fulvic acids (FA) and humin (HU), improve nutrient cycling by stimulating microbial activity and enhancing nutrient transport. Together, BC and HSs provide synergistic benefits for soil health, particularly in challenging environments like saline or nutrient-depleted soils. This review highlights the roles of BC and HSs in enhancing soil fertility, promoting N mineralization, and improving crop productivity. It emphasizes their potential for sustainable agricultural practices, climate change mitigation, and long-term soil health. Keywords: Biochar, Climate changes, Humic substances, Remediation, Soil fertility.
Potenciar la multidisciplinariedad y empleabilidad en Publicidad a través de una experiencia de innovación docente
Authors: Rangel-Pérez Celia , Núñez-Gómez Patricia , Rodríguez-Perujo Germán 
Published: December 2024

La industria publicitaria demanda profesionales capaces de seguir el ritmo de transformación de los cambios tecnológicos con la incorporación de herramientas como la Inteligencia Artificial Generativa que facilita muchas de las competencias técnicas. Por eso, desde la universidad se debe fomentar la formación crítica e integral del estudiantado, a la vez que se potencie la formación dual con el sector de la publicidad desde las etapas iniciales de la formación universitaria. Para demostrarlo, se llevó a cabo una experiencia de innovación docente que consistió en una visita voluntaria a la agencia de publicidad BTOB con el estudiantado de 1º de Publicidad y Relaciones Públicas (RR.PP.) para estudiar el cambio de percepciones antes y después de la actividad. Entre los resultados destaca cómo el acompañamiento y la formación participativa entre universidad y empresas de la industria publicitaria resultan esenciales para fomentar la multidisciplinariedad y la empleabilidad entre el alumnado del Grado de Publicidad y RR.PP. Además, mejoraron las percepciones de las agencias de publicidad como un buen lugar para trabajar, cambiaron las ideas iniciales sobre en qué departamento encajar mejor dentro de una agencia de publicidad, así como la necesidad de mejorar su formación transversal frente a la técnica.
Critical Discourse Analysis on Portraying the CODE-PLAN Model to Create Lesson Plan
Authors: Azizah Shofiah Nur 
Published: December 2024

This library research critically examined the specific cognitive skills teachers need to create effective lesson plans using the CODE-PLAN model. The study explored how the dimensions of content, social context, and time interact to influence lesson planning and identified six key strands such as content transformation, task creation, adaptation to learning disposition, clarity of learning objectives, unit contextualization, and phasing. The researcher used a qualitative descriptive-analytical method and content analysis to analyze the data. The study aimed to highlight the cognitive demands essential for effective lesson planning. The findings suggest that applying the CODE-PLAN model could enhance teachers’ instructional practices, thereby improving educational quality and student learning outcomes. However, challenges in teacher training and resource limitations need to be addressed for successful implementation. Moreover, the research contributes to the field by providing a framework for understanding and improving the cognitive demands in lesson planning, potentially guiding curriculum design and teacher training programs.

Keywords: CODE-PLAN Model, Cognitive Skills, Lesson Plan
Analisis Warna Retro pada Elemen Artistik sebagai Pendukung Visusl Waktu Film Smugglers 2023
Authors: Surgawi Fellina 
Published: December 2024

Film "Smugglers" mengisahkan tentang sekelompok penyelam wanita yang terlibat dalam penyelundupan ilegal untuk memenuhi kebutuhan hidup dan mendukung orang-orang di sekitar mereka. Salah satu aspek menarik dari film ini adalah penggunaan warna retro pada elemen artistiknya, yang memainkan peran penting dalam menggambarkan era 1970an secara visual. Pewarnaan yang tidak konvensional pada properti tertentu juga disesuaikan dengan palet warna yang dipilih untuk menambah kedalaman era tersebut. Penelitian ini, yang berjudul "Analisis Warna Retro pada Elemen Artistik sebagai Pendukung Visual dalam Film Smugglers," bertujuan untuk menganalisis bagaimana warna, lebih dari sekadar bentuk properti, membantu memberikan identitas waktu dan memperkuat visualisasi era dalam cerita. Penelitian ini mengeksplorasi seberapa signifikan peranan warna dalam membentuk visual suatu zaman. Penelitian ini menggunakan metode eksperimental dalam kerangka penelitian kualitatif untuk menguji hipotesis terkait sampel yang dijadikan objek penelitian. Fokus analisis adalah pada warna retro dalam elemen artistik seperti setting ruang, pakaian, properti, tata rias, dan pencahayaan yang digunakan untuk mendukung visual waktu dalam film Smugglers. Berdasarkan hasil penelitian, proses identifikasi warna pada elemen artistik dan karakteristik warna retro yang ditemukan dalam film "Smugglers" menunjukkan bahwa film ini memiliki karakteristik warna retro yang kuat, sesuai dengan teori yang menjadi dasar penelitian ini. Dominasi warna retro dalam sampel yang diteliti menegaskan peran penting warna sebagai pendukung visual dalam menggambarkan waktu cerita, membuktikan hipotesis awal penelitian.
Diagnósticos de enfermagem em pessoas idosas hospitalizadas relacionados à contenção física
Authors: Fernandes Maria das Graças Melo , Alcoforado Josicleide Montenegro da Silva Guedes , Barbosa Tayane Paiva Layme , Cavalcanti Emanuele Paula Lopes , Beserra Patrícia Josefa Fernandes 
Published: December 2024

Objetivos: Identificar na literatura consequências da contenção física em pessoas idosas hospitalizadas e mapear essas repercussões com indicadores clínicos de diagnósticos de enfermagem da NANDA-I. Métodos: Estudo de revisão integrativa cujo foco foi a comparação entre os achados com os indicadores clínicos de diagnósticos de enfermagem. O período da coleta de dados compreendeu abril a maio de 2024. Resultados: Após a triagem inicial da literatura foram identifiados 79 estudos que versavam sobre o tema, avaliados na íntegra em uma segunda etapa, resultando em 23 publicações. Resultados: Foram encontrados nove diagnósticos de enfermagem. Considerou-se “mobilidade física prejudicada” como fator determinante, dado ao fato de ocorrer, segundo a NANDA-I, quando há uma limitação independente e voluntária do corpo, a exemplo das restrições de mobilidade. As características definidoras dos diagnósticos representativos das consequências da contenção física foram estabelecidas a partir do mapeamento entre achados da literatura e elementos de diagnósticos contemplados na NANDA-I. Considerações finais: Faz-se necessário que os enfermeiros atentem sobre o uso indevido de contenção em pessoas idosas, assim como desenvolver protocolos para prevenir e tratar consequências negativas relacionadas a essa prática no ambito do cuidado.
Судебный поединок в законах и практике Древней Руси
Authors: Рыжов В.Б. 
Published: December 2024

Исследование судебных поединков в законодательной базе и правовой практике в период Древнерусского государства представляется значимым ввиду слабой изученности данного вопроса на материалах юридических памятников времен Киевской Руси. Между тем детальный анализ текстов законодательных актов, преимущественно Русской Правды, позволяет охарактеризовать причины возникновения данного метода решения судебных тяжб, а также особенности его практической реализации. В статье автор исследует значение термина «судебный поединок», а конкретнее — его русского аналога «поля», место и роль последнего в юридических памятниках и судебной практике Древнерусского государства.
The study of judicial fights in the legislative framework and legal practice during the period of the Old Russian state seems to be significant due to the poor study of this issue on the materials of legal monuments from the times of Kievan Rus. Meanwhile, a detailed analysis of the texts of legislative acts, mainly of Russkaya Pravda, makes it possible to characterize the reasons for the emergence of this method of resolving litigation, as well as the features of its practical implementation. In this article, the author explores the meaning of the term "judicial duel", and specifically, its Russian counterpart - "field", the place and role of the latter in the legal monuments and judicial practice of the Old Russian state.
Принципы гражданского права и законодательства в культуре судебного правоприменения
Authors: Комиссарова Е.Г. 
Published: December 2024

Логические объемы научно-теоретической проблемы принципов гражданского права и законодательства продолжают возрастать. Теория ее познания традиционно выстраивается в контексте знаний о предмете и методе гражданско-правового регулирования. В настоящей статье автор исследует новый методологический профиль научного освоения этой проблематики, который позволит сменить консервативную ориентацию теории принципов на более прогрессивную, имеющую практическую направленность на область правоприменения. Тезис о прогрессивности теории принципов автор связывает с конституционной линией ее исследования, от которой исходят все части правовой системы, включая отраслевые принципы. Подобный подход не противоречит научной тенденции последнего научного десятилетия, насыщенного систематическими попытками уточнить понятийный аппарат принципов частного права, предмет и метод гражданского права, основные признаки частного права и методологию его исследования.
The logical volumes of the scientific and theoretical problem of the principles of civil law and legislation continue to increase. The theory of its cognition is traditionally built in the context of knowledge about the subject and method of civil law regulation. In this article, the author explores a new methodological profile of the scientific development of this problem, which will allow changing the conservative orientation of the theory of principles to a more progressive one with a practical focus on the field of law enforcement. The author connects the thesis about the progressiveness of the theory of principles with the constitutional line of its research, from which all parts of the legal system, including sectoral principles, proceed. Such an approach does not contradict the scientific trend of the last scientific decade, saturated with systematic attempts to clarify the conceptual apparatus of the principles of private law, the subject and method of civil law, the main features of private law and the methodology of its research.