bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonthyroidal Illness Syndrome and Hypothyroidism in Ischemic Heart Disease Population: A Systematic Review and Meta-Analysis
Authors: Chang Chun-Yu , Chien Yung-Jiun , Lin Po-Chen , Chen Chien-Sheng , Wu Meng-Yu 
Published: May 2020

Abstract

Context
The association of non-thyroidal illness syndrome (NTIS) and hypothyroidism with the prognosis in ischemic heart disease (IHD) population is inconclusive.

Objective
We aimed to evaluate the influence of NTIS and hypothyroidism on all-cause mortality and major adverse cardiac events (MACE) in IHD population.

Data Sources
We searched PubMed, EMBASE, Scopus, Web of Science, and Cochrane Library from inception through February 17, 2020.

Study Selection
Original articles enrolling IHD patients, comparing all-cause mortality and MACE of NTIS and hypothyroidism with those of euthyroidism, and providing sufficient information for meta-analysis were considered eligible.

Data Extraction
Relevant information and numerical data were extracted for methodological assessment and meta-analysis.

Data Synthesis
Twenty-three studies were included. The IHD population with NTIS was associated with higher risk of all-cause mortality (hazard ratio [HR] = 2.61; 95% confidence interval [CI] = 1.89-3.59) and MACE (HR = 2.22; 95% CI = 1.71-2.89) than that without. In addition, the IHD population with hypothyroidism was also associated with higher risk of all-cause mortality (HR = 1.47; 95% CI = 1.10-1.97) and MACE (HR = 1.53; 95% CI = 1.19-1.97) than that without. In the subgroup analysis, the acute coronary syndrome (ACS) subpopulation with NTIS was associated with higher risk of all-cause mortality (HR = 3.30; 95% CI = 2.43-4.48) and MACE (HR = 2.19; 95% CI = 1.45-3.30). The ACS subpopulation with hypothyroidism was also associated with higher risk of all-cause mortality (HR = 1.67; 95% CI = 1.17-2.39).

Conclusions
The IHD population with concomitant NTIS or hypothyroidism was associated with higher risk of all-cause mortality and MACE. Future research is required to provide evidence of the causal relationship and to elucidate whether normalizing thyroid function parameters can improve prognosis.
The zebrafish as a novel model for the in vivo study of Toxoplasma gondii replication and interaction with macrophages
Authors: Yoshida Nagisa , Domart Marie-Charlotte , Peddie Christopher J. , Yakimovich Artur , Mazon-Moya Maria J. , Hawkins Thomas A. , Collinson Lucy , Mercer Jason , Frickel Eva-Maria , Mostowy Serge 
Published: May 2020

ABSTRACT
Toxoplasma gondii is an obligate intracellular parasite capable of invading any nucleated cell. Three main clonal lineages (type I, II, III) exist and murine models have driven the understanding of general and strain-specific immune mechanisms underlying Toxoplasma infection. However, murine models are limited for studying parasite-leukocyte interactions in vivo, and discrepancies exist between cellular immune responses observed in mouse versus human cells. Here, we developed a zebrafish infection model to study the innate immune response to Toxoplasma in vivo. By infecting the zebrafish hindbrain ventricle, and using high-resolution microscopy techniques coupled with computer vision-driven automated image analysis, we reveal that Toxoplasma invades brain cells and replicates inside a parasitophorous vacuole to which type I and III parasites recruit host cell mitochondria. We also show that type II and III strains maintain a higher infectious burden than type I strains. To understand how parasites are cleared in vivo, we further analyzed Toxoplasma-macrophage interactions using time-lapse microscopy and three-dimensional correlative light and electron microscopy (3D CLEM). Time-lapse microscopy revealed that macrophages are recruited to the infection site and play a key role in Toxoplasma control. High-resolution 3D CLEM revealed parasitophorous vacuole breakage in brain cells and macrophages in vivo, suggesting that cell-intrinsic mechanisms may be used to destroy the intracellular niche of tachyzoites. Together, our results demonstrate in vivo control of Toxoplasma by macrophages, and highlight the possibility that zebrafish may be further exploited as a novel model system for discoveries within the field of parasite immunity.
This article has an associated First Person interview with the first author of the paper.
The impact of community containment implementation timing on the spread of COVID-19: A simulation study
Authors: Mohsen Attayeb , Alarabi Ahmed 
Published: May 2020

Background: Community containment is one of the common methods used to mitigate infectious disease outbreaks. The effectiveness of such a method depends on how strictly it is applied and the timing of its implementation. An early start and being strict is very effective; however, at the same time, it impacts freedom and economic opportunity. Here we created a simulation model to understand the effect of the starting day of community containment on the ﬁnal outcome, that is, the number of those infected, hospitalized and those that died, as we followed the dynamics of COVID-19 pandemic. Methods: We used a stochastic recursive simulation method to apply disease outbreak dynamics measures of COVID-19 as an example to simulate disease spread. Parameters are allowed to be randomly assigned between higher and lower values obtained from published COVID-19 literature. Results: We simulated the dynamics of COVID-19 spread, calculated the number of active infections, hospitalizations and deaths as the outcome of our simulation and compared these results with real world data. We also represented the details of the spread in a network graph structure, and shared the code for the simulation model to be used for examining other variables. Conclusions: Early implementation of community containment has a big impact on the ﬁnal outcome of an outbreak.
Tartu Riiklik Ülikool julgeolekuorganite huviorbiidis 1950. aastal [Abstract: Tartu State University in the sphere of interest of the state security organs in 1950]
Authors: Tannberg Tõnu 
Published: May 2020

Abstract: Tartu State University in the sphere of interest of the state security organs in 1950
After the re-occupation of Estonia in 1944, the Soviets launched an extensive and diverse process of Sovietisation for building a new society. An important instrument in this campaign was the struggle that had been unleashed against so-called bourgeois nationalism. This ‘struggle’ culminated with the notorious 8th Plenum of the Central Committee of the Estonian Communist (Bolshevik) Party that was held in March of 1950, where the former Communist Party leader of the Estonian SSR Nikolai Karotamm was removed from his post and the campaign for purging ‘anti- Soviet elements’ from various spheres of life, which had already began in the first year of Soviet occupation, was given even more of a free hand.
In the eyes of the regime, the Tartu State University of that time was also an important ‘nest of bourgeois nationalism’, for which reason it is not surprising that the state security organs demonstrated greater than usual interest in that institution. At the end of the 1940s, the 5th Section of the Tartu Department of the Estonian SSR Ministry of State Security scrutinised the university with the personal participation of the section head and a state security senior operative officer.49 The thorough ‘mapping’ of the university’s staff was carried out by the state security organs in the early spring of 1950. As a result of this, several lengthy reports were completed that provide an overview of the university’s network of agents and the ‘littering’ of the university ‘with anti-Soviet elements’. Yet these reports contain other interesting information. Valentin Moskalenko, who had only just been appointed Minister of State Security of the Estonian SSR at the start of 1950, reported to Moscow on the prevailing situation at the university in June of 1950.50 Yet it was not until September of that year that he notified the leadership of the Estonian SSR headed by Johannes (Ivan) Käbin, who ascended to power in March of 1950.51 It is noteworthy that statistical data on the network of agents operating at the university was also added to the end of the report sent to Moscow, but Käbin was not informed of that.
V. Moskalenko’s report that was sent to Moscow is published below along with essential commentaries. Jaan Isotamm (1939–2014) translated and commented on this document within the framework of a long-past research project of the compiler of this publication. The compiler of this publication has also previously published a separate article that draws on the above-mentioned reports.
The change in the intensity of symptoms in children and adolescents with attention deficit hyperactivity disorder after “Workshops for Parents of Hyperactive Children”
Authors: Pisula Agnieszka , Bryńska Anita , Wójtowicz Stanisław , Srebnicki Tomasz , Wolańczyk Tomasz 
Published: May 2020

Cel pracyOcena zmian w zakresie nasilenia objawów ADHD u dzieci i młodzieży, których rodzice uczestniczyli w ‘Warsztatach dla rodziców dzieci nadpobudliwych’.Metodagrupę eksperymentalną stanowili rodzice n=199 dzieci i młodzieży z rozpoznaniem ADHD, uczestniczący w 12-tygodniowym programie warsztatowym, grupę odniesienia rodzice n=24 dzieci i młodzieży z ADHD, uczestniczący w czasie 12-tygodni w 1-2 standardowych wizytach lekarskich (treatment as usual). Metoda: w czasie pierwszego i ostatniego spotkania warsztatowego poproszono o wypełnienie kwestionariuszy: CBCL oraz Conners-IOWA-10 (ocena dziecka przez rodzica), TRF oraz Conners-RCTRS-28 (ocena dziecka przez nauczyciela/wychowawcę), YRS (ocena dokonana przez dziecko, jeśli ukończyło 11 r.ż.). Dzieci i młodzież z grupy odniesienia poddano takiej samej, dwukrotnej ocenie po pierwszej wizycie w poradni i po 12 tygodniach.Wynikiosoby uczestniczące w programie warsztatów byli w większości rodzicami chłopców z rozpoznaniem podtypu mieszanego ADHD ze współwystępującymi lub bez opozycyjno-buntowniczych zaburzeń zachowania oraz podtypu ADHD z przewagą zaburzeń uwagi. W grupie eksperymentalnej istotne zmniejszenie nasilenia objawów wykazano dla ocen matek we wszystkich skalach Conners-IOWA-10 oraz w następujących skalach CBCL: Problemy społeczne, Zaburzenia uwagi, Zachowania agresywne, Zachowania eksternalizacyjne oraz w zakresie Wyniku całkowitego. Poprawa była niezależna od rodzaju ustalonego rozpoznania oraz prowadzonego leczenia farmakologicznego.Wnioskioceniany program prowadzi do redukcji nasilenia objawów w umiarkowanym lub małym zakresie, niezależnie od podtypu zaburzenia, współwystępujących opozycyjno-buntowniczych zaburzeń zachownia, a także stosowanej, lub też nie, farmakoterapii.
The Effect of Patent Protection on Inventor Mobility
Authors: Melero Eduardo , Palomeras Neus , Wehrheim David 
Published: May 2020

This article investigates the effect of patent protection on the mobility of early-career employee-inventors. Using data on patent applications filed at the U.S. Patent and Trademark Office between 2001 and 2012 and examiner leniency as a source of exogenous variation in patent protection, we find that one additional patent granted decreases the likelihood of changing employers, on average, by 23%. This decrease is stronger when the employee has fewer coinventors, works outside the core of the firm, and produces more basic-research innovations. These findings are consistent with the idea that patents turn innovation-related skills into patent-holder-specific human capital.This paper was accepted by Ashish Arora, entrepreneurship and innovation.
Caracterização Hidrogeológica do Aquífero Freático da Unidade 3 da Univiçosa
Authors: Cândido Miranda Edson Henrique , Anselmo da Mata Rafles , Pereira Luana Cláudia 
Published: May 2020

Diante do avanço das simulações de águas subterrâneas nos últimos anos como forma de propor soluções para gestão de recursos hídricos, a presente pesquisa teve como objetivo a elaboração de um modelo hidrogeológico conceitual para o aquífero freático da Unidade 3 da Univiçosa, em que foi analisado o rebaixamento do nível de água do lençol freático através dos dados de bombeamento dos poços existentes no local e obtidos os parâmetros hidrodinâmicos do aquífero através do software Aquifer Test. Também foram realizadas análises potenciométricas dos poços bem como a relação entre a precipitação e a recarga do aquífero por intermédio de campanhas de monitoramento dos níveis de água estático e dinâmico dos poços e do regime de precipitação da região no intuito de se compreender o comportamento do lençol freático da região. Foi verificado que houve diferentes respostas ao bombeamento para os poços denominados “Frente Esquerda” e “Fundos Direita”, este último devido a um pequeno lago em sua proximidade. Durante a recuperação ambos os poços se comportaram de maneira semelhante em que os níveis de água atingiram valores acima dos medidos antes dos testes de bombeamento, porém com o poço “Fundos Direita” atingindo valores muito acima, por volta de 1,75 m a mais do que o nível medido antes do teste de bombeamento. Os valores dos parâmetros hidrodinâmicos encontrados foram: Transmissividade (T) 1,0 x 10-3 m2/s, Condutividade Hidráulica (K) 4,17 x 10-5 m/s e Armazenamento (S) 1,0 x 10-4. Estes valores permitiram a obtenção do Raio de influência dos poços sendo possível constatar a não sobreposição dos cones de rebaixamento entre os poços “Frente Esquerda” e “Fundos Direita”. A análise potenciométrica permitiu verificar o comportamento do fluxo de água entre os poços, incluindo um terceiro denominado “Residencial”, sendo constatado que em regime estacionário a água flui dos poços de maior para os de menor cota altimétrica e em regime transitório, quando há bombeamento, ela flui em direção aos poços. A análise da relação entre a precipitação e a recarga do aquífero não foi significativa, mostrando pequenas variações nos níveis estáticos da água dos poços em períodos chuvosos, o que leva a crer que a quantidade de água precipitada e o período de monitoramento não foram suficientes para constatar alterações nos níveis de água do lençol freático. Por fim, foi constatado que a explotação de água dos poços não compromete a quantidade de água no local, visto que não há interferência entre eles, porém recomenda-se a execução de sondagens nas proximidades dos poços para melhor caracterização dos mesmos e ampliação do período de monitoramento para melhor conhecimento do comportamento do aquífero freático local por meio da elaboração de um modelo hidrogeológico matemático.
Selection of Thermal Integrity Data Regression Parameters
Authors: Mullins Gray , Johnson Kevin R. , Winters Danny , Hilferding Hida , Kupselaitis Kurt 
Published: May 2020

Abstract
Thermal integrity profiling (TIP) is a nondestructive method of evaluating the as-built features of cast-in-place concrete foundation elements such as bored piles, drilled shafts, continuous flight auger piles, barrettes, dams, or diaphragm walls. The technology measures the temperature of curing concrete along the length of the element to detect the presence (or absence) of hydrating cement, alignment of the reinforcing steel, and rebar cover thickness. Like many integrity methods used for drilled shafts, direct comparison of local concrete conditions are made relative to the overall normal or average concrete conditions with two exceptions: the top and bottom of the element, which cannot be directly compared with the rest of the shaft temperature without adjusting those measurements to account for end effects. This paper outlines the selection of the end adjustment parameters to ensure the top and bottom shapes are properly defined. The presented data regression process is based on both numerical model findings as well as the statistical findings from 232 TIP-tested shafts on the same project.
Foam Concrete Pore Structure Effect on Drying Shrinkage and Frost Resistance
Authors: Gong Jianqing , Zhang Wenjie , Zhou Zihao 
Published: May 2020

Abstract
Foam concrete has two major shortcomings resulting primarily from pore structure: high drying shrinkage and weak frost resistance. This article reports on a study of how various water-cement ratios affect high drying shrinkage and weak frost resistance. Stereomicroscopy, acoustic wave, and nitrogen adsorption methods measured macroporous and microscopic pore structures to analyze drying shrinkage and frost resistance mechanisms. Drying shrinkage was shown to gradually increase as water-cement ratios increased from 0.4 to 0.7. This can be attributed to increased water loss via capillary holes and greater capillary tension. Frost resistance maximized at a water-cement ratio of 0.5. As the water-to-cement ratio increased from 0.4 to 0.5, accessible pores with an average size of 10–50 nm increased. The volume of harmful 50–200-nm pores and pores larger than 200 nm increased. When water-cement ratios increased from 0.5 to 0.7, the number of 0–200-μm pores decreased sharply, whereas pores larger than 400 μm increased dramatically.
Integración, inclusión y justicia social: Reflexiones desde las normativas inclusivas en la educación chilena
Authors: Véliz Jorquera Paulina , Martínez María Jesús , Parra Muñoz Hugo , Garrido Reyes Catalina 
Published: May 2020

Desde 2009, el sistema educacional chileno ha vivido una serie de ajustes y reformas estructurales tendientes a construir escuelas inclusivas que responden a las demandas sociales de equidad y calidad. Este proceso, con continuidades y rupturas, es abordado en este estudio para comprender los sentidos y alcances de lo que se ha comprendido por sistema educativo inclusivo orientado a la justicia social. En este contexto presentamos el despliegue analítico de una investigación cualitativa desarrollada entre los años 2017-2019 que cuestiona sobre los sentidos discursivos latentes en las políticas educativas en Chile en torno a la diversidad e inclusión en el sistema educacional. Se desarrolla una investigación política documental cualitativa, con un enfoque teórico hermenéutico con aspectos críticos. Este proceso investigativo ha encontrado que las configuraciones y reestructuraciones -a nivel paradigmático y social- que han emergido desde las políticas educativas responden a una fuente integradora y no a una matriz inclusiva; esto bajo una declaración discursiva relativa a la intención de entregar servicios educacionales de calidad y equitativos a la población escolar, que presenten o no condición de discapacidad. Otro resultado destacado en este artículo hace referencia a los cambios emergentes que se observaron durante el tránsito desde el enfoque integrativo al inclusivo; aspectos como los modos de materialización del discurso inclusivo en las aulas regulares, aquellos que proponen la diversificación de enseñanza y la eliminación de barreras frente al aprendizaje. Finalmente, el artículo reflexiona sobre el sustento y el análisis del recorrido de las políticas públicas educativas de carácter inclusivo que se han promulgado en la última década en Chile, declarando los silencios y contradicciones entre ellas.
Procoagulatio, hypercoagulatio és fibrinolysis „shut down” kimutatása ClotPro® viszkoelasztikus tesztek segítségével COVID–19-betegekben.
Authors: Zátroch István , Smudla Anikó , Babik Barna , Tánczos Krisztián , Kóbori László , Szabó Zsuzsanna , Fazakas János 
Published: May 2020

Absztrakt:
Bevezetés: Nemzetközi tapasztalatok alapján a
COVID–19-fertőzött, kórházban kezelt betegek több mint 30%-ában vénás, artériás
és microvascularis thrombosis, disszeminált intravascularis véralvadási zavar,
illetve thromboembolia alakul ki. Ennek laboratóriumi jellemzői a magas D-dimer-
és fibrinogénszint, valamint a megnyúlt prothrombinidő és aktivált parciális
thromboplastinidő. Módszer: Az esetbemutatások során intenzív
osztályon kezelt, COVID–19-fertőzött betegek (n = 3) ClotPro®
trombolasztométeres (EX-test, IN-test, FIB-test, RVV-test és TPA-test)
eredményeit értékeltük a klinikai állapottal összefüggésben.
Eredmények: A ClotPro®-paraméterek procoagulatiót,
hypercoagulatiót, fibrinolysist vagy annak „shut down” megnyilvánulását
jelezték, és összhangban voltak a hagyományos alvadási tesztekkel, illetve a
kompenzált disszeminált intravascularis coagulopathia meghatározásával.
Következtetés: Eredményeink magyarázatot adhatnak a vénás
thromboemboliás szövődményekre, támogatják a terápiás alvadásgátló kezelés és a
thrombocytaaggregáció-gátlás fontosságát. A gyógyszer típusának, adagolási
algoritmusának, optimális időtartamának meghatározásához intervenciós klinikai
vizsgálatok szükségesek, ezek engedélyeztetése folyamatban van. Orv Hetil. 2020;
161(22): 899–907.
The 1922 Peninsula Malaysia Earthquakes: Rare Intraplate Seismicity within the Sundaland Block in Southeast Asia
Authors: Martin Stacey Servito , Wang Yu , Muzli Muzli , Wei Shengji 
Published: May 2020

AbstractSeismic hazard in the southern Malay Peninsula located within the Sundaland block in Southeast Asia is poorly understood. The paucity of historical earthquakes and low-magnitude instrumented seismicity has led to the assumption that this region is largely aseismic. We question this point of view by reassessing historical seismicity in this region and, in particular, a pair of moderate earthquakes in the 1920s. The first of these struck on 31 January 1922 at ≈9:10  a.m. local time (LT) for which we estimate an intensity magnitude (MI) ≈5.4, and for the second earthquake on 7 February 1922 at ≈12:15  p.m. LT, we estimate MI≈5.0. We also identify at least 34 felt earthquakes between 1803 and 1950 that were potentially local within the Sundaland block. These include a very widely felt shock (or set of shocks) on 26 June 1874 that was felt in parts of Borneo, Java, and Sumatra. The discovery of these earthquakes challenges the tectonic stability of the Malay Peninsula and the stable interior of the Sundaland block. The record of historical seismicity in this region relies heavily on European sources, and we recommend locating and consulting indigenous sources to improve the current understanding of regional seismic hazard. We also underscore the need to evaluate the impact of ground motions from rare local earthquakes on the extant building stock and on transportation infrastructure that are otherwise relatively immune to the long-period effects of distant earthquakes commonly felt in the Malay Peninsula.
THE ING NGARSA SUNG TULADHA COOPERATIVE LEARNING MODEL AND STUDENTS' PROBLEM SOLVING ABILITIES
Authors: Hutagaol Kartini , Saija Louise , Panjaitan Maru M. J. 
Published: May 2020

<p>This paper describes one way that teachers as educators can face the challenges of the industrial revolution 4.0, namely by instilling and preparing creative and character-based leaders. Education as character building can be implemented using Ki Hajar Dewantara's leadership concepts, namely Ing Ngarsa Sung Tuladha, Ing Madya Mangun Karsa, and Tut Wuri Handayani. The concept of leadership was first adopted as a cooperative learning model which emphasized exemplariness in group learning. The group leader is called tuladha and is the facilitator of the group. Tuladha utilizes the Internet of Things. Before the teaching and learning process in class, information, concepts or ideas, and examples are posted by the teacher to the tuladha. This study is an experimental study with the sample used meeting the prerequisites of the statistical test used. The results showed that students' mathematical problem solving abilities increased significantly using the Ing Ngarsa Sung Tuladha cooperative learning model over the usual method. The category of improving students' mathematical problem solving abilities that obtain the Ing Ngarsa Sung Tuladha cooperative learning model is in the high category.</p>