bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eliminating turbulent self-interaction through the parallel boundary condition in local gyrokinetic simulations
Authors: Ball Justin , Brunner Stephan , C.J. Ajay 
Published: March 2020

In this work, we highlight an issue that may reduce the accuracy of many local nonlinear gyrokinetic simulations – turbulent self-interaction through the parallel boundary condition. Given a sufficiently long parallel correlation length, individual turbulent eddies can span the full domain and ‘bite their own tails’, thereby altering their statistical properties. Such self-interaction is only modelled accurately when the simulation domain corresponds to a full flux surface, otherwise it is artificially strong. For Cyclone Base Case parameters and typical domain sizes, we find that this mechanism modifies the heat flux by approximately 40 % and it can be even more important. The effect is largest when using kinetic electrons, low magnetic shear and strong turbulence drive (i.e. steep background gradients). It is found that parallel self-interaction can be eliminated by increasing the parallel length and/or the binormal width of the simulation domain until convergence is achieved.
The Battle over National Schooling in Bohemia and the Czech and German National School Associations: A Comparison (1880–1914)
Authors: Zvánovec Mikuláš 
Published: March 2020

AbstractLiberal political changes in the Habsburg monarchy during the 1860s and 1870s, especially those caused by the December Constitution of 1867 and the ensuing schooling laws, created the necessary legal framework for German and Czech school associations to establish national monolingual schools in Bohemia—the so-called minority schools. These local organizations, however, were soon superseded by central school associations, namely the German association in Vienna (Deutscher Schulverein) and the Czech one in Prague (Ústřední Matice Školská). Founded in 1880, these associations were aimed at schools in the linguistically, and therefore nationally, contested regions along the “language frontier.” This study focuses on the dynamics of the national contestation over schooling prior to World War I and compares the activities of these two associations against the background of political democratization, mass mobilization, and the social questions of the fin de siècle. The comparative analysis of the proclamations, activities, and political contacts of the competing central school associations aims at revising theses about the position and meaning of these organizations and shows their very close interdependence upon political processes, especially on the unsuccessful Czech-German negotiations on a national compromise for Bohemia.
Legal smart contracts for derivative trading in mining
Authors: Wise Julian Adam , Chan Meng Chak , Tadic Dihon , Miles Stephanie , Cornish Jack , Sellers Ewan , Brenecki David , Dzakpata Isaac , Murugesan Barti 
Published: March 2020

Abstract
This research demonstrates financial derivative trade of unprocessed materials, for the mining industry through legal smart contracts. Within the mining supply chain, a stock of mined resources can reside in a mineral stockpile for over twenty years without gaining financial interest and without undergoing the mineral extraction process to derive value from the asset. This research elaborates on a blockchain solution implemented to increase miners’ short-term cash flow for business operations through the issuance of derivative assets on mineral stockpiles which can be traded through legally binding smart contracts. The system is the first to enable mining companies’ access to the underlying asset’s value earlier in the production lifecycle through smart contract technology whilst providing hedge funds with access to new financial products for investment portfolios.
PREDICTING L2 FLUENCY FROM L1 FLUENCY BEHAVIOR
Authors: Duran-Karaoz Zeynep , Tavakoli Parvaneh 
Published: March 2020

AbstractThe article reports on the findings of a study investigating the relationship between first language (L1) and second language (L2) fluency behavior. Drawing on data collected from Turkish learners of English, the study also addresses the question of whether proficiency level mediates the relationship, if any. The data were coded for a range of breakdown, repair, speed, and composite measures. Language proficiency was measured by means of two tests: Oxford Placement Test (OPT) and an Elicited Imitation Task (EIT). The results show that some breakdown and repair measures were positively correlated in L1 and L2, but no correlations were observed for articulation rate and speech rate. The relationships were not mediated by proficiency level. Regression analyses show that a number of models predicted L2 fluency. L1 fluency contributed significantly to models predicting pausing behavior; EIT scores predicted L2 speech rate; and L1 fluency and OPT scores predicted L2 repair and mid-clause pauses. The important implications of the findings for fluency research and second language pedagogy are discussed.
A citizen science survey discloses the current distribution of the endangered Yellow CardinalGubernatrix cristatain Argentina
Authors: DOMÍNGUEZ MARISOL , LAPIDO ROCÍO , GORRINDO ADRIÁN , ARCHUBY DIEGO , CORREA EMILIO , LLANOS FABIÁN , REALES FABRICIO , PIANTANIDA FABRIZIO , MARATEO GERMÁN , MERIGGI JORGE , ANDREANI LUCAS , ENCABO MANUEL , VINASSA MARÍA LAURA GÓMEZ , BERTINI MAXIMILIANO , PERELLÓ MILTON , BANCHS RICARDO , CIRIGNOLI SEBASTIÁN , VERÓN SILVINA , MAHLER BETTINA 
Published: March 2020

SummaryThe Yellow CardinalGubernatrix cristatais a globally endangered passerine from the southern cone of South America. Because of its conspicuous plumage and very attractive song, it suffers considerably from illegal pet trade. The largest remaining populations are found in Argentina, but no coordinated efforts have been made thus far to understand better its current distribution and conservation status. During three annual surveys supported by a citizen science programme, more than 140 volunteers surveyed 644 geographical points during spring and detected 221 Yellow Cardinals. Based on the survey results, we evaluated the presence of cardinals within protected areas in Argentina and found that the species was only detected in four of them, two of which were private reserves with a low level of protection. We also found that the species was not restricted to the ‘Espinal’ ecoregion, but also inhabited ‘Monte’ and ‘Chaco’ ecoregions, which are generally drier. This citizen science programme allowed us to obtain up-to-date information on the remaining populations of the Yellow Cardinal and helped to increase public awareness about the conservation problems faced by the species. We propose some future strategies for monitoring Yellow Cardinals and taking informed conservation decisions.
Investigation of transfer results of human embryos that were vitrified and thawed at the cleavage, morula and blastocyst stages
Authors: Korkmaz Cem , Gül Yıldız Ümmü , Fidan Ulaş , Baykal Barış , Temel Ceyhan Seyit , Ağaçayak Elif 
Published: March 2020

SummaryThe objective of this study was to compare the rates of clinical pregnancy after the transfer of vitrified and thawed human embryos on days 3, 4 and 5 of embryonic development. In this retrospective study, the results of 148 embryo transfer cycles, using embryos frozen and thawed over the 3-year period between January 2016 and December 2018 at the Gülhane Training and Research Hospital Department of Gynecology and Obsterics Reproductive Medical Center of the University of Health Sciences, Ankara, Turkey were examined. Following embryo transfer – including 29 dissolved embryos frozen on day 3, 80 frozen on day 4, and 39 frozen on day 5 – results were examined in terms of clinical pregnancy rates. In this study, across all three groups, no significant differences were observed in terms of patient age, the number of oocytes collected, infertility reasons, the number of embryos dissolved, transfer day, or the number of embryos transferred. According to the transfer day, the rates of clinical pregnancy and ongoing pregnancy were significantly higher for embryos frozen on day 4 and transferred on day 5. Significantly higher rates of pregnancy and live birth were determined during in vitro fertilization (IVF) treatment with the freezing of human embryos on day 4 and the transfer of those embryos on day 5.
Value of transferring embryos derived from monopronucleated (1PN) zygotes at the time of fertilization assessment
Authors: Li Ming , Dang Yujiao , Wang Ying , Li Junsheng , Liu Ping 
Published: March 2020

SummaryThis paper is a retrospective analysis of the sole transfer of monopronucleated zygotes (1PN) embryos both in in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) to determine the value of transferring embryos formed from 1PN. In fresh cycles, 1PN cleavage-stage embryos (1PN cleavage fresh) were transferred. In frozen–thawed cycles, 1PN blastocyst-stage embryos (1PN blast frozen) were transferred. We used comparison groups: for fresh cycles, 2PN cleavage-stage embryos (2PN cleavage fresh) were transferred; and for frozen–thawed cycles, 2PN blastocyst-stage embryos (2PN blast frozen) were transferred. Comparison groups were matched for cycle and patient characteristics to the 1PN group. Finally, for fresh cycles, live birth rates (LBR) in the 1PN cleavage group were significantly lower than those in 2PN cleavage group, both for IVF [LBR = 7.64% vs. pregnancy rate (PR) = 22.12%, P = 0.003, respectively] and ICSI (LBR = 0% vs. LBR = 20.00%, P < 0.001, respectively). For frozen–thawed IVF cycles, the PR in the 1PN blastocyst group were comparable with those of the 2PN blastocyst group (1PN: LBR = 33.14% vs. 2PN: LBR = 37.24%, P = 0.289, respectively), while in ICSI, the PR in the 1PN blastocyst group were lower than those in the 2PN blastocyst group (LBR = 15.25% vs. LBR = 40.68%, P = 0.002, respectively). So, for IVF, blastocyst culture was capable of selecting normal 1PN embryos for transfer and achieves satisfying outcomes. However, for ICSI, blastocyst culture was not effective enough to eliminate abnormal embryos and 1PN embryo transfer needed to be treated with caution.
Mental health consequences for survivors of the 2011 Fukushima nuclear disaster: a systematic review. Part 1: psychological consequences
Authors: Shigemura Jun , Terayama Takero , Kurosawa Mie , Kobayashi Yuki , Toda Hiroyuki , Nagamine Masanori , Yoshino Aihide 
Published: March 2020

AbstractTo integrate scholastic literature regarding the prevalence and characteristics of the psychological consequences faced by survivors of the 2011 Fukushima earthquake/tsunami/nuclear disaster, we conducted a systematic review of survivor studies concerning the Fukushima disaster. In August 2019, four literature databases (PubMed, PsycINFO, Psychology and Behavioral Sciences Collection, and ICHUSHI) were used in the literature search. Peer-reviewed manuscripts reporting psychological consequences, either in English or Japanese, were selected. A total of 79 studies were selected for the review. Twenty-four studies (30.4%) were conducted as part of the Fukushima Health Management Survey—large-scale cohort study recruiting the residents of the entire Fukushima prefecture. Study outcomes were primarily nonspecific psychological distress, depressive symptoms, post-traumatic stress symptoms, and anxiety symptoms. The rates of high-risk individuals determined by the studies varied significantly owing to methodological differences. Nevertheless, these rates were mostly high (nonspecific psychological distress, 8.3%-65.1%; depressive symptoms, 12%-52.0%; and post-traumatic stress symptoms, 10.5%-62.6%). Many studies focused on vulnerable populations such as children, mothers of young children, evacuees, and nuclear power plant workers. However, few studies reported on the intervention methods used or their effect on the survivors. As a conclusion, high rates of individuals with psychological conditions, as well as a wide range of mental conditions, were reported among the Fukushima nuclear disaster survivors in the first 8 years after the disaster. These findings demonstrate the substantial impact of this compound disaster, especially in the context of a nuclear catastrophe.
Open‐Source Software Analysis Tool to Investigate Space Plasma Turbulence and Nonlinear DYNamics (ODYN)
Authors: Teodorescu E. , Echim M.M. 
Published: March 2020

AbstractWe have designed and built a versatile modularized software library—ODYN—that wraps a comprehensive set of advanced data analysis methods meant to facilitate the study of turbulence, nonlinear dynamics, and complexity in space plasmas. The Python programming language is used for the algorithmic implementation of models and methods devised to understand fundamental phenomena of space plasma physics like elements of spectral analysis, probability distribution functions and their moments, multifractal analysis, or information theory. ODYN is an open‐source software analysis tool and freely available to any user interested in turbulence and nonlinear dynamics analysis and provides a tool to perform automatic analysis on large collections of space measurements, in situ or simulations, a feature that distinguishes ODYN from other similar software. A user‐friendly configurator is provided, which allows customization of key parameters of the analysis methods, most useful for nonprogrammers.
Future Changes in the Occurrence of Hybrid Cyclones: The Added Value of Cyclone Classification for the East Australian Low‐Pressure Systems
Authors: Cavicchia L. , Pepler A. , Dowdy A. , Evans J. , Di Luca A. , Walsh K. 
Published: March 2020

AbstractSeveral regions of the world, including the east coast of Australia, are characterized by the occurrence of low‐pressure systems with a range of different dynamical structures, including tropical, extratropical, and hybrid cyclones. Future changes in the occurrence of cyclones are better understood if storms are classified according to their dynamical structure. Therefore, we apply a classification of cyclones according to their cold‐core or warm‐core structure to an ensemble of regional climate model simulations. First, we show that historical simulations reproduce well the reanalysis results in terms of cyclone classification. We then show that once cyclone classification is applied, projections of future cyclone activity become more robust, including a decrease in the occurrence of both cold‐core and warm‐core cyclones. Finally, we show that in a warmer climate warm‐core hybrid cyclone activity could increase close to the coast, while the associated rainfall and wind are projected to increase.
Disturbance Extraction for Burst Detection in Water Distribution Networks Using Pressure Measurements
Authors: Xu Weirong , Zhou Xiao , Xin Kunlun , Boxall Joby , Yan Hexiang , Tao Tao 
Published: March 2020

AbstractPipe bursts in water distribution networks cause considerable water losses and lead to potential environmental hazards. Effective burst detection methods enable water companies to repair broken pipes in a timely manner and minimize damage and disruption. A data‐driven detection method is developed and proven for real‐time leak and burst detection in water distribution networks. The method uses a unique integration of disturbance extraction and isolation forest techniques to enable detection of subtle burst signals from normally noisy pressure data. Verification and validation progress from synthetic data to the application to real‐life data from large‐scale open networks. The method is shown to generate comparable levels of detection, with low false positive rates, to other published techniques but without the need to introduce closed valves and expensive flow meters of district meter area structures and the loss of resilience these cause. The method offers the potential to effectively detect bursts from pressure data alone, helping to better manage the distribution of increasingly stressed water resources through aging pipe networks.
Comprehensive review of targeted therapy for colorectal cancer
Authors: Xie Yuan-Hong , Chen Ying-Xuan , Fang Jing-Yuan 
Published: March 2020

AbstractColorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and chemotherapy have long been the first choices for cancer patients. However, the prognosis of CRC has never been satisfying, especially for patients with metastatic lesions. Targeted therapy is a new optional approach that has successfully prolonged overall survival for CRC patients. Following successes with the anti-EGFR (epidermal growth factor receptor) agent cetuximab and the anti-angiogenesis agent bevacizumab, new agents blocking different critical pathways as well as immune checkpoints are emerging at an unprecedented rate. Guidelines worldwide are currently updating the recommended targeted drugs on the basis of the increasing number of high-quality clinical trials. This review provides an overview of existing CRC-targeted agents and their underlying mechanisms, as well as a discussion of their limitations and future trends.
Treosulfan–fludarabine–thiotepa-based conditioning treatment before allogeneic hematopoietic stem cell transplantation for pediatric patients with hematological malignancies
Authors: Kalwak Krzysztof , Mielcarek Monika , Patrick Katharine , Styczynski Jan , Bader Peter , Corbacioglu Selim , Burkhardt Birgit , Sykora Karl Walter , Drabko Katarzyna , Gozdzik Jolanta , Fagioli Franca , Greil Johann , Gruhn Bernd , Beier Rita , Locatelli Franco , Müller Ingo , Schlegel Paul Gerhardt , Sedlacek Petr , Stachel Klaus Daniel , Hemmelmann Claudia , Möller Ann-Kristin , Baumgart Joachim , Vora Ajay 
Published: March 2020

AbstractTreosulfan-based conditioning prior to allogeneic transplantation has been shown to have myeloablative, immunosuppressive, and antineoplastic effects associated with reduced non-relapse mortality (NRM) in adults. Therefore, we prospectively evaluated the safety and efficacy of treosulfan-based conditioning in children with hematological malignancies in this phase II trial. Overall, 65 children with acute lymphoblastic leukemia (35.4%), acute myeloid leukemia (44.6%), myelodysplastic syndrome (15.4%), or juvenile myelomonocytic leukemia (4.6%) received treosulfan intravenously at a dose of 10 mg/m2/day (7.7%), 12 g/m2/day (35.4%), or 14 g/m2/day (56.9%) according to their individual body surface area in combination with fludarabine and thiotepa. The incidence of complete donor chimerism at day +28 was 98.4% with no primary and only one secondary graft failure. At 36 months, NRM was only 3.1%, while relapse incidence was 21.7%, and overall survival was 83.0%. The cumulative incidence of acute graft-vs.-host disease was 45.3% for grades I–IV and 26.6% for grades II–IV. At 36 months, 25.8% overall and 19.4% moderate/severe chronic graft-vs.-host disease were reported. These data confirm the safe and effective use of treosulfan-based conditioning in pediatric patients with hematological malignancies. Therefore, treosulfan/fludarabine/thiotepa can be recommended for myeloablative conditioning in children with hematological malignancies.
An injectable photopolymerized hydrogel with antimicrobial and biocompatible properties for infected skin regeneration
Authors: Sun Ao , He Xinye , Li Lang , Li Tao , Liu Qinya , Zhou Xinli , Ji Xiao , Li Wei , Qian Zhiyong 
Published: March 2020

Abstract
Currently, wound infection is an important health problem for the public. Wound infection can not only hinder healing but it can also lead to serious complications. Injectable wound dressings with biocompatible and antibacterial properties can promote wound healing during skin infections and reduce antibiotic use. Here, we used glycidyl methacrylate (GMA) to modify ε-polylysine (ε-PL) and γ-poly(glutamic acid) (γ-PGA) to produce ε-polylysine-glycidyl methacrylate (ε-PL-GMA) and γ-poly(glutamic acid)-glycidyl methacrylate (γ-PGA-GMA). Subsequently, ε-PL-GMA- and γ-PGA-GMA-based hydrogels were developed through photopolymerization using visible light. The hydrogels were injectable, could rapidly gelatinize, were biocompatible, and showed a wide spectrum of antibacterial activity. The hydrogels also promoted wound healing. The results show that these hydrogels inhibit bacterial infection and shorten the wound healing time of skin defects in Staphylococcus aureus models. This demonstrates that the hydrogels hold potential for clinical antimicrobial and wound healing therapy.
Post-translational coordination of chlorophyll biosynthesis and breakdown by BCMs maintains chlorophyll homeostasis during leaf development
Authors: Wang Peng , Richter Andreas S. , Kleeberg Julius R. W. , Geimer Stefan , Grimm Bernhard 
Published: March 2020

AbstractChlorophyll is indispensable for life on Earth. Dynamic control of chlorophyll level, determined by the relative rates of chlorophyll anabolism and catabolism, ensures optimal photosynthesis and plant fitness. How plants post-translationally coordinate these two antagonistic pathways during their lifespan remains enigmatic. Here, we show that two Arabidopsis paralogs of BALANCE of CHLOROPHYLL METABOLISM (BCM) act as functionally conserved scaffold proteins to regulate the trade-off between chlorophyll synthesis and breakdown. During early leaf development, BCM1 interacts with GENOMES UNCOUPLED 4 to stimulate Mg-chelatase activity, thus optimizing chlorophyll synthesis. Meanwhile, BCM1’s interaction with Mg-dechelatase promotes degradation of the latter, thereby preventing chlorophyll degradation. At the onset of leaf senescence, BCM2 is up-regulated relative to BCM1, and plays a conserved role in attenuating chlorophyll degradation. These results support a model in which post-translational regulators promote chlorophyll homeostasis by adjusting the balance between chlorophyll biosynthesis and breakdown during leaf development.
Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity
Authors: von Roemeling Christina A. , Wang Yifan , Qie Yaqing , Yuan Hengfeng , Zhao Hai , Liu Xiujie , Yang Zhaogang , Yang Mingming , Deng Weiye , Bruno Katelyn A. , Chan Charles K. , Lee Andrew S. , Rosenfeld Stephen S. , Yun Kyuson , Johnson Aaron J. , Mitchell Duane A. , Jiang Wen , Kim Betty Y. S. 
Published: March 2020

AbstractTumour cell phagocytosis by antigen presenting cells (APCs) is critical to the generation of antitumour immunity. However, cancer cells can evade phagocytosis by upregulating anti-phagocytosis molecule CD47. Here, we show that CD47 blockade alone is inefficient in stimulating glioma cell phagocytosis. However, combining CD47 blockade with temozolomide results in a significant pro-phagocytosis effect due to the latter’s ability to induce endoplasmic reticulum stress response. Increased tumour cell phagocytosis subsequently enhances antigen cross-presentation and activation of cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS–STING) in APCs, resulting in more efficient T cell priming. This bridging of innate and adaptive responses inhibits glioma growth, but also activates immune checkpoint. Sequential administration of an anti-PD1 antibody overcomes this potential adaptive resistance. Together, these findings reveal a dynamic relationship between innate and adaptive immune regulation in tumours and support further investigation of phagocytosis modulation as a strategy to enhance cancer immunotherapy responses.