bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aerial roots of orchids: the velamen radicum as a porous material for efficient imbibition of water
Authors: Hauber Frank , Konrad Wilfried , Roth-Nebelsick Anita 
Published: October 2020

AbstractAerial roots of orchids are able to absorb atmospheric water (e.g. rain, mist, dew) and to conduct it to the root interior. The water is absorbed by imbibition into a biological porous material, the velamen radicum, which envelops the aerial root and comprises one or two to several layers. The velamen radicum consists of walls of dead cells and shows an intricate structure. In this contribution, the imbibition process was studied in more detail using mathematical principles and by experimental observation of eight orchid species. The process of absorption can be subdivided into two stages. The initial stage is the attachment of a drop to the rough surface. The drop is then imbibed into the layers of the velamen radicum. During imbibition, the contact angle decreases, because the drop remains firmly pinned to the surface. Imbibition times vary widely, due to differences in the porous structure of the considered species. It could, however, be demonstrated that a detailed theoretical study of imbibition for this complex biological material is possible using structural parameters obtained from microscope images. A third aspect which was considered was evaporation out of the velamen radicum. Also here, observations were consistent with modeling results. The velamen radicum, and other tissues involved in water absorption by aerial roots of orchids, represents an intriguing biological material for studying imbibition and flow in porous materials and has probably a high potential for discovering technically interesting features.
The course of multiple sclerosis rewritten: a Norwegian population-based study on disease demographics and progression
Authors: Simonsen Cecilia Smith , Flemmen Heidi Øyen , Broch Line , Brunborg Cathrine , Berg-Hansen Pål , Moen Stine Marit , Celius Elisabeth Gulowsen 
Published: October 2020

Abstract
Objectives
Over the past few decades, there has been an improvement in the rate of disability progression in multiple sclerosis (MS) patients, and most studies relate this evolvement to the introduction of disease-modifying therapies. However, several other factors have changed over this period, including access to MRI and newer diagnostic criteria. The aim of this study is to investigate changes in the natural course of MS over time in a near-complete and geographically well-defined population from the south-east of Norway.

Methods
We examined disease progression and demographics over two decades and assessed the effect of disease-modifying therapies using linear mixed-effect models.

Results
In a cohort of 2097 patients, we found a significant improvement in disability as measured by the Expanded Disability Status Scale (EDSS) stratified by age, and the improvement remained significant after adjusting for time on disease-modifying medications, gender and progressive MS at onset. The time from disease onset to EDSS 6 in the total cohort was 29.8 years (95% CI 28.5–31.1) and was significantly longer in patients diagnosed after 2006 compared to patients diagnosed before. There are significant differences between patient demographics, as well as time to EDSS 6, in the near-complete, geographically well-defined population compared to an additional cohort from the capital Oslo and its suburbs.

Conclusion
The natural course of MS is improving, but the improvement seen in disease progression has multifaceted explanations. Our study underlines the importance of completeness of data, relevant timeframes and demographics when comparing different MS populations. Studies on incomplete populations should be interpreted with caution.
Unraveling the contributions to the neuromelanin-MRI contrast
Authors: Priovoulos Nikos , van Boxel Stan C. J. , Jacobs Heidi I. L. , Poser Benedikt A. , Uludag Kamil , Verhey Frans R. J. , Ivanov Dimo 
Published: October 2020

AbstractThe Locus Coeruleus (LC) and the Substantia Nigra (SN) are small brainstem nuclei that change with aging and may be involved in the development of various neurodegenerative and psychiatric diseases. Magnetization Transfer (MT) MRI has been shown to facilitate LC and the SN visualization, and the observed contrast is assumed to be related to neuromelanin accumulation. Imaging these nuclei may have predictive value for the progression of various diseases, but interpretation of previous studies is hindered by the fact that the precise biological source of the contrast remains unclear, though several hypotheses have been put forward. To inform clinical studies on the possible biological interpretation of the LC- and SN contrast, we examined an agar-based phantom containing samples of natural Sepia melanin and synthetic Cys-Dopa-Melanin and compared this to the in vivo human LC and SN. T1 and T2* maps, MT spectra and relaxation times of the phantom, the LC and the SN were measured, and a two-pool MT model was fitted. Additionally, Bloch simulations and a transient MT experiment were conducted to confirm the findings. Overall, our results indicate that Neuromelanin-MRI contrast in the LC likely results from a lower macromolecular fraction, thus facilitating interpretation of results in clinical populations. We further demonstrate that in older individuals T1 lengthening occurs in the LC.
Prevalence and risk factors of lactic acidosis in children with acute moderate and severe asthma, a prospective observational study
Authors: Ruman-Colombier Marta , Rochat Guignard Isabelle , Di Paolo Ermindo R. , Gehri Mario , Pauchard Jean-Yves 
Published: October 2020

AbstractLactic acidosis is a common complication of status asthmaticus in adults. However, data is sparse in children. The aim of this study was to describe the prevalence and risk factors for lactic acidosis in children hospitalised for acute moderate or severe asthma. A total of 154 children 2–17 years of age were enrolled in a prospective observational study conducted in a tertiary hospital. All had capillary blood gas assessment 4 h after the first dose of salbutamol in hospital. The primary endpoint was the prevalence of lactic acidosis. Potential contributing factors such as age, sex, BMI, initial degree of asthma severity, type of salbutamol administration (nebuliser or inhaler), steroids, ipratropium bromide, and glucose-containing maintenance fluid represented secondary endpoints. All in all, 87% of patients had hyperlactatemia (lactate concentration > 2.2 mmol/l). Lactic acidosis (lactate concentration > 5 mmol/l and anion gap ≥ 16 mmol/l) was observed in 26%. In multivariate analysis, age more than 6 years (OR = 2.8, 95% CI 1.2–6.6), glycemia above 11 mmol/l (OR = 3.2 95% CI 1.4–7.4), and salbutamol administered by nebuliser (OR = 10, 95% CI 2.7–47) were identified as risk factors for lactic acidosis in children with moderate or severe asthma.Conclusion: Lactic acidosis is a frequent and early complication of acute moderate or severe asthma in children.

What is Known:• Lactic acidosis during acute asthma is associated with b2-mimetics administration.• Salbutamol-related lactic acidosis is self-limited but important to recognise, as compensatory hyperventilation of lactic acidosis can be mistaken for respiratory worsening and lead to inappropriate supplemental bronchodilator administration.What is New:• Lactic acidosis is a frequent complication of acute asthma in the paediatric population.• Age older than 6 years, hyperglycaemia, and nebulised salbutamol are risk factors for lactic acidosis during asthma.
Characterization of anisotropic turbulence behavior in pulsatile blood flow
Authors: Andersson Magnus , Karlsson Matts 
Published: October 2020

AbstractTurbulent-like hemodynamics with prominent cycle-to-cycle flow variations have received increased attention as a potential stimulus for cardiovascular diseases. These turbulent conditions are typically evaluated in a statistical sense from single scalars extracted from ensemble-averaged tensors (such as the Reynolds stress tensor), limiting the amount of information that can be used for physical interpretations and quality assessments of numerical models. In this study, barycentric anisotropy invariant mapping was used to demonstrate an efficient and comprehensive approach to characterize turbulence-related tensor fields in patient-specific cardiovascular flows, obtained from scale-resolving large eddy simulations. These techniques were also used to analyze some common modeling compromises as well as MRI turbulence measurements through an idealized constriction. The proposed method found explicit sites of elevated turbulence anisotropy, including a broad but time-varying spectrum of characteristics over the flow deceleration phase, which was different for both the steady inflow and Reynolds-averaged Navier–Stokes modeling assumptions. Qualitatively, the MRI results showed overall expected post-stenotic turbulence characteristics, however, also with apparent regions of unrealizable or conceivably physically unrealistic conditions, including the highest turbulence intensity ranges. These findings suggest that more detailed studies of MRI-measured turbulence fields are needed, which hopefully can be assisted by more comprehensive evaluation tools such as the once described herein.
Standardization of Propagation Models for Terrestrial Cellular Systems: A Historical Perspective
Authors: Tataria Harsh , Haneda Katsuyuki , Molisch Andreas F. , Shafi Mansoor , Tufvesson Fredrik 
Published: October 2020

AbstractPropagation models constitute a fundamental building block of wireless communications research. Before we build and operate real systems, we must understand the science of radio propagation, and develop channel models that both reflect the important propagation processes and allow a fair comparison of different systems. In the past five decades, wireless systems have gone through five generations, from supporting voice applications to enhanced mobile broadband. To meet the ever increasing data rate demands of wireless systems, frequency bands covering a wide range from 800 MHz to 100 GHz have been allocated for use. The standardization of these systems started in the early/mid 1980s in Europe by the European Telecommunications Standards Institute with the advent of Global System for Mobile Communications. This motivated the development of the first standardized propagation model by the European Cooperation in Science and Technology (COST) 207 working group. These standardization activities were continued and expanded for the third, fourth, and fifth generations of COST, as well as by the Third Generation Partnership Project, and the International Telecommnunication Union. This paper presents a historical overview of the standardized propagation models covering first to fifth-generation systems. In particular, we discuss the evolution and standardization of pathloss models, as well as large and small-scale fading parameters for single antenna and multiple antenna systems. Furthermore, we present insights into the progress of deterministic modelling across the five generations of systems, as well as discuss more advanced modelling components needed for the detailed simulations of millimeter-wave channels. A comprehensive bibliography at the end of the paper will aid the interested reader to dig deeper.
IVIVC for Extended Release Hydrophilic Matrix Tablets in Consideration of Biorelevant Mechanical Stress
Authors: Mohylyuk Valentyn , Goldoozian Seyedreza , Andrews Gavin P. , Dashevskiy Andriy 
Published: October 2020

Abstract
Purpose
When establishing IVIVC, a special problem arises by interpretation of averaged in vivo profiles insight of considerable individual variations in term of time and number of mechanical stress events in GI-tract. The objective of the study was to investigate and forecast the effect of mechanical stress on in vivo behavior in human of hydrophilic matrix tablets.

Methods
Dissolution profiles for the marketed products were obtained at different conditions (stirring speed, single- or repeatable mechanical stress applied) and convoluted into C-t profiles. Vice versa, published in vivo C-t profiles of the products were deconvoluted into absorption profiles and compared with dissolution profiles by similarity factor.

Results
Investigated hydrophilic matrix tablets varied in term of their resistance against hydrodynamic stress or single stress during the dissolution. Different scenarios, including repeatable mechanical stress, were investigated on mostly prone Seroquel® XR 50 mg. None of the particular scenarios fits to the published in vivo C-t profile of Seroquel® XR 50 mg representing, however, the average of individual profiles related to scenarios differing by number, frequency and time of contraction stress. When different scenarios were combined in different proportions, the profiles became closer to the original in vivo profile including a burst between 4 and 5 h, probably, due to stress-events in GI-tract.

Conclusion
For establishing IVIVC of oral dosage forms susceptible mechanical stress, a comparison of the deconvoluted individual in vivo profiles with in vitro profiles of different dissolution scenarios can be recommended.
Individual recovery of health-related quality of life during 18 months post-burn using a retrospective pre-burn measurement: an exploratory study
Authors: Boersma-van Dam Elise , van de Schoot Rens , Hofland Helma W. C. , Engelhard Iris M. , Van Loey Nancy E. E. 
Published: October 2020

Abstract
Purpose
This study explored the individual trajectories of health-related quality of life (HRQL) compared to recalled pre-burn level of HRQL and investigated whether burn severity and post-traumatic stress disorder (PTSD) symptoms increase the risk of not returning to pre-burn level of HRQL.

Methods
Data were obtained from 309 adult patients with burns in a multicenter study. Patients completed the EQ-5D-3L questionnaire with a Cognition bolt-on shortly after hospital admission, which included a recalled pre-injury measure, and, again, at 3, 6, 12 and 18 months post-burn. Burn severity was indicated by the number of surgeries, and PTSD symptoms were assessed with the IES-R at three months post-burn. Pre- and post-injury HRQL were compared to norm populations.

Results
Recalled pre-injury HRQL was higher than population norms and HRQL at 18 months post-burn was comparable to population norms. Compared to the pre-injury level of functioning, four HRQL patterns of change over time were established: Stable, Recovery, Deterioration, and Growth. In each HRQL domain, a subset of patients did not return to their recalled pre-injury levels, especially with regard to Pain, Anxiety/Depression, and Cognition. Patients with more severe burns or PTSD symptoms were less likely to return to pre-injury level of functioning within 18 months post-burn.

Conclusion
This study identified four patterns of individual change. Patients with more severe injuries and PTSD symptoms were more at risk of not returning to their recalled pre-injury HRQL. This study supports the face validity of using a recalled pre-burn HRQL score as a reference point to monitor HRQL after burns.
Future Missions Related to the Determination of the Elemental and Isotopic Composition of Earth, Moon and the Terrestrial Planets
Authors: Dandouras Iannis , Blanc Michel , Fossati Luca , Gerasimov Mikhail , Guenther Eike W. , Kislyakova Kristina G. , Lammer Helmut , Lin Yangting , Marty Bernard , Mazelle Christian , Rugheimer Sarah , Scherf Manuel , Sotin Christophe , Sproß Laurenz , Tachibana Shogo , Wurz Peter , Yamauchi Masatoshi 
Published: October 2020

AbstractIn this chapter, we review the contribution of space missions to the determination of the elemental and isotopic composition of Earth, Moon and the terrestrial planets, with special emphasis on currently planned and future missions. We show how these missions are going to significantly contribute to, or sometimes revolutionise, our understanding of planetary evolution, from formation to the possible emergence of life. We start with the Earth, which is a unique habitable body with actual life, and that is strongly related to its atmosphere. The new wave of missions to the Moon is then reviewed, which are going to study its formation history, the structure and dynamics of its tenuous exosphere and the interaction of the Moon’s surface and exosphere with the different sources of plasma and radiation of its environment, including the solar wind and the escaping Earth’s upper atmosphere. Missions to study the noble gas atmospheres of the terrestrial planets, Venus and Mars, are then examined. These missions are expected to trace the evolutionary paths of these two noble gas atmospheres, with a special emphasis on understanding the effect of atmospheric escape on the fate of water. Future missions to these planets will be key to help us establishing a comparative view of the evolution of climates and habitability at Earth, Venus and Mars, one of the most important and challenging open questions of planetary science. Finally, as the detection and characterisation of exoplanets is currently revolutionising the scope of planetary science, we review the missions aiming to characterise the internal structure and the atmospheres of these exoplanets.
Confirmation bias without rhyme or reason
Authors: Michel Matthias , Peters Megan A. K. 
Published: October 2020

AbstractHaving a confirmation bias sometimes leads us to hold inaccurate beliefs. So, the puzzle goes: why do we have it? According to the influential argumentative theory of reasoning, confirmation bias emerges because the primary function of reason is not to form accurate beliefs, but to convince others that we’re right. A crucial prediction of the theory, then, is that confirmation bias should be found only in the reasoning domain. In this article, we argue that there is evidence that confirmation bias does exist outside the reasoning domain. This undermines the main evidential basis for the argumentative theory of reasoning. In presenting the relevant evidence, we explore why having such confirmation bias may not be maladaptive.
Assessment of Groundwater Quality Changes in the Rural Environment of the Hungarian Great Plain Based on Selected Water Quality Indicators
Authors: Mester Tamás , Balla Dániel , Szabó György 
Published: October 2020

AbstractIn the present study, changes in groundwater quality are assessed after the construction of the sewerage network, based on 3 water quality indices. Sampling took place before (2013) and after (2017, 2018, 2019) the establishment of a sewerage network in 2014. In the pre-sewerage period, strong pollution of the groundwater was detected. A total of 90% of the groundwater wells according to the water quality status by Brown, 70% of the wells according to the contamination index Cd by Rapant, and 80% of the wells according to the Canadian Council of Ministers of the Environmental Water Quality Index were categorized in the “polluted” or “heavily polluted” categories. After the establishment of the sewerage, significant changes were observed. In 2017, the number of wells in category 5 indicating the most contaminated samples decreased significantly for all three indices, while the number of samples in categories “good” and “acceptable” increased. Discriminant analysis was performed to determine if pre- and post-sewerage samples could be separated. A total of 75.6% of the cross-validated values were successfully categorized into the appropriate category, which indicates a significant difference between pre- and post-sewerage. Based on point and interpolated maps, it was established that in 2013, all three indices showed the highest pollution in the inner and southern parts of the settlement, while the northern areas of the settlement were less polluted. Based on the indices, it was determined that the process of groundwater purification in the settlement has started, although it will continue for years to come.
First Case Report of Fulminant Hepatitis After Laparoscopic Sleeve Gastrectomy Associated with Concomitant Maximal Therapeutic Dose of Acetaminophen Use, Protein Calorie Malnutrition, and Vitamins A and D, Selenium, and Glutathione Deficiencies
Authors: Abusabeib Alyaa , El Ansari Walid , Alobaidan Jassim , Elhag Wahiba 
Published: October 2020

AbstractNonalcoholic fatty liver disease (NAFLD) is increasingly being linked to obesity. Although laparoscopic sleeve gastrectomy (LSG) is effective for weight loss that can ultimately resolve NAFLD, an initial transient deterioration of liver functions could be observed during the first few months post-operatively, after which a subsequent improvement of the liver functions might occur. Rapid weight loss, nutritional deficiencies, and protein malnutrition can all contribute to hepatic dysfunction and can affect the metabolism of medications such as acetaminophen leading to more insult to a compromised liver. We report acute liver failure after LSG associated with protein calorie malnutrition, multiple nutritional deficiencies in addition to concomitant use of therapeutic doses of acetaminophen. Treatment with N-acetylcysteine, and replacement of deficient multivitamins and trace elements resulted in significant improvement in liver functions.
Interaktionen schlafbezogener Atmungsstörungen mit Vorhofflimmern
Authors: Vaas Victoria , Fisser Christoph , Tafelmeier Maria , Linz Dominik , Arzt Michael 
Published: October 2020

ZusammenfassungHintergrundVorhofflimmern (VHF) ist die häufigste Herzrhythmusstörung. Sowohl die zentrale als auch die obstruktive Schlafapnoe interagieren mit dieser Erkrankung. Intermittierende Hypoxie, oxidativer Stress, wiederkehrende Aufwachreaktionen, intrathorakale Druckveränderungen und atriales Remodeling können im Rahmen einer schlafbezogenen Atmungsstörung (SBAS) zu VHF führen.ZielDieser Artikel stellt die komplexen Zusammenhänge und Erkenntnisse jüngster Forschungen bezüglich SBAS und VHF sowie die Therapiemöglichkeiten dar.Material und MethodenEs erfolgten eine Literaturrecherche von Original- und Übersichtsartikeln sowie Metaanalysen, die zwischen 1963 und 2020 in der PubMed-Datenbank veröffentlicht wurden.ErgebnisseDie Erkenntnisse der Studien weisen auf einen bidirektionalen kausalen Zusammenhang zwischen SBAS und VHF hin. Die pathophysiologischen Auswirkungen der obstruktiven und zentralen Schlafapnoe auf VHF sind unterschiedlich. Die Studien, die die Effekte einer Therapie der SBAS auf das Rezidivrisiko von VHF nach Intervention (Kardioversion oder Pulmonalvenenisolation) untersuchen, ergeben bisher kein eindeutiges Bild.DiskussionBisherige Studien bestätigen multiple Interaktionen zwischen SBAS und VHF. Aufgrund widersprüchlicher Ergebnisse hinsichtlich der Effekte einer positiven Atemwegsdrucktherapie auf das Rezidivrisiko von VHF nach Interventionen sind weitere Studien nötig.
HDGlab: An Open-Source Implementation of the Hybridisable Discontinuous Galerkin Method in MATLAB
Authors: Giacomini Matteo , Sevilla Ruben , Huerta Antonio 
Published: October 2020

AbstractThis paper presents , an open source MATLAB implementation of the hybridisable discontinuous Galerkin (HDG) method. The main goal is to provide a detailed description of both the HDG method for elliptic problems and its implementation available in . Ultimately, this is expected to make this relatively new advanced discretisation method more accessible to the computational engineering community. presents some features not available in other implementations of the HDG method that can be found in the free domain. First, it implements high-order polynomial shape functions up to degree nine, with both equally-spaced and Fekete nodal distributions. Second, it supports curved isoparametric simplicial elements in two and three dimensions. Third, it supports non-uniform degree polynomial approximations and it provides a flexible structure to devise degree adaptivity strategies. Finally, an interface with the open-source high-order mesh generator is provided to facilitate its application to practical engineering problems.