bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid depletion of dissolved organic sulphur (DOS) in freshwaters
Authors: Brailsford F. L. , Glanville H. C. , Wang D. , Golyshin P. N. , Johnes P. J. , Yates C. A. , Jones D. L. 
Published: May 2020

AbstractSulphur (S) is a key macronutrient for all organisms, with similar cellular requirements to that of phosphorus (P). Studies of S cycling have often focused on the inorganic fraction, however, there is strong evidence to suggest that freshwater microorganisms may also access dissolved organic S (DOS) compounds (e.g. S-containing amino acids). The aim of this study was to compare the relative concentration and depletion rates of organic 35S-labelled amino acids (cysteine, methionine) with inorganic S (Na235SO4) in oligotrophic versus mesotrophic river waters draining from low nutrient input and moderate nutrient input land uses respectively. Our results showed that inorganic SO42− was present in the water column at much higher concentrations than free amino acids. In contrast to SO42−, however, cysteine and methionine were both rapidly depleted from the mesotrophic and oligotrophic waters with a halving time < 1 h. Only a small proportion of the DOS removed from solution was mineralized and excreted as SO42− (< 16% of the total taken up) suggesting that the DOS could be satisfying a demand for carbon (C) and S. In conclusion, even though inorganic S was abundant in freshwater, it appears that the aquatic communities retained the capacity to take up and assimilate DOS.
Seasonal variation in estuarine phytoplankton viability and its relationship with carbon dynamics in the Baltic Sea
Authors: Elovaara Samu , Degerlund Maria , Franklin Daniel J. , Kaartokallio Hermanni , Tamelander Tobias 
Published: May 2020

AbstractCell death drives the magnitude and community composition of phytoplankton and can result in the conversion of particulate organic carbon to dissolved organic carbon (DOC), thereby affecting carbon cycling in the aquatic food web. We used a membrane integrity probe (Sytox Green) to study the seasonal variation in the percentage of viable cells in the phytoplankton population in an estuary in the northern Baltic Sea for 21 months. The associated dissolved and particulate organic matter concentrations were also studied. The viable fraction of phytoplankton cells varied from < 20% to almost 100%, with an average of 62%. Viability was highest when a single phytoplankton group (diatoms or dinoflagellates) dominated the community. Viability of sinking phytoplankton cells, including some motile species, was in general as high as in surface water. Changes in viability were not closely related to nutrient concentrations, virus-like particle abundance, seawater temperature or salinity. There was a weak but significant negative correlation between viability and DOC, although at this location, the DOC pool was mainly influenced by the inflow of riverine water. This study demonstrates that cell viability, and its relationship with carbon export, is highly variable in the complex microbial populations common within estuarine and coastal marine ecosystems.
What goes around, comes around? Access and allocation problems in Global North–South waste trade
Authors: Cotta Benedetta 
Published: May 2020

AbstractInfamous cases of toxic waste trade and research on its health and environmental implications have made the global waste trade a prominent environmental and social justice issue. Recently, such trade has shifted towards extracting resources from waste as recyclable components and used goods which could create income-generating opportunities and reduce the environmental burdens of waste trade from Global North to Global South countries. Nevertheless, studies highlight persistent problems in the access to these resources and allocation of responsibilities, risks and burdens from processing and disposal of traded waste in Global South countries. This article aims to contribute to the lessons learnt on access and allocation with respect to waste trade by focusing on issues of equity, fairness and distributive justice. Two cases are analysed: trade in discarded electronic and electric equipment (EEE) between the EU and Africa and trade in plastic materials between the UK and China. This study shows that exports of used EEE and recyclable plastic materials exacerbate the environmental burdens of Global South countries while also exporting new environmental risks and social burdens. At the same time, new demands for justice have emerged from Global South countries through waste ship back initiatives, and new international measures have also been adopted. While the access and allocation lens enabled the identification of persistent problems in Global North–South waste trade, directing future Earth System Governance research to the demands emerging from the Global South countries could offer insights into how to better address these problems and deal with growing global inequalities.
Deterministic global optimization of steam cycles using the IAPWS-IF97 model
Authors: Bongartz Dominik , Najman Jaromił , Mitsos Alexander 
Published: May 2020

AbstractThe IAPWS-IF97 (Wagner et al. (2000) J Eng Gas Turbines Power 122:150) is the state-of-the-art model for the thermodynamic properties of water and steam for industrial applications and is routinely used for simulations of steam power cycles and utility systems. Its use in optimization-based design, however, has been limited because of its complexity. In particular, deterministic global optimization of problems with the IAPWS-IF97 is challenging because general-purpose methods lead to rather weak convex and concave relaxations, thus resulting in slow convergence. Furthermore, the original domains of many functions from the IAPWS-IF97 are nonconvex, while common global solvers construct relaxations over rectangular domains. Outside the original domains, however, many of the functions take very large values that lead to even weaker relaxations. Therefore, we develop tighter relaxations of relevant functions from the IAPWS-IF97 on the basis of an analysis of their monotonicity and convexity properties. We modify the functions outside their original domains to enable tighter relaxations, while we keep them unchanged on their original domains where they have physical meaning. We discuss the benefit of the relaxations for three case studies on the design of bottoming cycles of combined cycle power plants using our open-source deterministic global solver MAiNGO. The derived relaxations result in drastic reductions in computational time compared with McCormick relaxations and can make design problems tractable for global optimization.
The epidemiology of aggressive pituitary tumors (and its challenges)
Authors: Dekkers Olaf M. , Karavitaki Niki , Pereira Alberto M. 
Published: May 2020

AbstractPituitary tumors are not rare if prevalence rates from autopsy or radiological series are considered; approximately 0.5% of all pituitary adenomas will come to medical attention. Less than 0.1% of these pituitary adenomas will become malignant, and probably around 0.5% of all detected adenomas will display an aggressive course. However, the exact incidence of both aggressive pituitary adenomas and pituitary carcinomas is unknown, as most data come from series with selected patients, such as surgically treated patients, which is likely not a reflection of all patients with a pituitary adenoma. An aggressive pituitary adenoma is not well-defined; even though an overarching definition, capturing both immunohistochemical and clinical characteristics is probably not waterproof, adoption of a widely accepted definition will be very helpful to harmonize research and establish more reliable epidemiological data.
Farming autonomy: Canadian beef farmers reclaiming the grass through management-intensive grazing practices
Authors: Heiberg Erika J. , Syse Karen Lykke 
Published: May 2020

AbstractThis qualitative study asks farmers in Alberta, Canada,what are their motivations for using a practice in beef production called management-intensive grazing (MIG). By adopting this practice, these farmers engage in strategies of diversification and co-production that increase the autonomy and resilience of their farms. MIG allows farmers to defy conventional agricultural practice and engage in what can be labelled a repeasantization process, a process that contributes to the discussion about conventional farming versus agroecology.
Intraventricular Hemorrhage in a Single Fetus of Dichorionic-Diamniotic Gestation: A Case Report and Review of Literature
Authors: Shelton Jarod , Yasmeh Pauline , Yang Lee 
Published: May 2020

AbstractIntraventricular hemorrhage (IVH) is a serious complication of prematurity and is of high concern due to the risk of brain injury and in severe cases, death. We report the first case of IVH in a fetus of dichorionic-diamniotic pregnancy that worsened postnatally. Antenatally, magnetic resonance imaging confirmed a large IVH after ventricular abnormalities were detected by prenatal ultrasound (US). At birth, a grade IV IVH diagnosis was made and progressive ventricle dilatation was noted on weekly US. A ventriculoperitoneal shunt was placed and ventricle dilatation was slightly reduced, however, the IVH was essentially unchanged. The infant was discharged in stable condition at 12-weeks-old and chronic neurological dysfunction is expected. IVH is seen in complicated births of prematurity and antenatal US can inform an examiner if fetal IVH is present. It is important to identify IVH and provide immediate intervention to prevent disease worsening during the antenatal and postnatal period.
A Superaerophobic Bimetallic Selenides Heterostructure for Efficient Industrial-Level Oxygen Evolution at Ultra-High Current Densities
Authors: Yuan Jiaxin , Cheng Xiaodi , Wang Hanqing , Lei Chaojun , Pardiwala Sameer , Yang Bin , Li Zhongjian , Zhang Qinghua , Lei Lecheng , Wang Shaobin , Hou Yang 
Published: May 2020

AbstractCost-effective and stable electrocatalysts with ultra-high current densities for electrochemical oxygen evolution reaction (OER) are critical to the energy crisis and environmental pollution. Herein, we report a superaerophobic three dimensional (3D) heterostructured nanowrinkles of bimetallic selenides consisting of crystalline NiSe2 and NiFe2Se4 grown on NiFe alloy (NiSe2/NiFe2Se4@NiFe) prepared by a thermal selenization procedure. In this unique 3D heterostructure, numerous nanowrinkles of NiSe2/NiFe2Se4 hybrid with a thickness of ~ 100 nm are grown on NiFe alloy in a uniform manner. Profiting by the large active surface area and high electronic conductivity, the superaerophobic NiSe2/NiFe2Se4@NiFe heterostructure exhibits excellent electrocatalytic activity and durability towards OER in alkaline media, outputting the low potentials of 1.53 and 1.54 V to achieve ultra-high current densities of 500 and 1000 mA cm−2, respectively, which is among the most active Ni/Fe-based selenides, and even superior to the benchmark Ir/C catalyst. The in-situ derived FeOOH and NiOOH species from NiSe2/NiFe2Se4@NiFe are deemed to be efficient active sites for OER.
Operation Navajeevan: A Public-Private Partnership Model for Disaster Relief in Kozhikode, India
Authors: Haris Sonia , Poovathumparambil Venugopalan , Anaswara Naveen , Noll Samantha , Ghatak-Roy Aditi , Dreyer Nicholas , Naik Nehal , Douglass Katherine , Blanchard Janice , Davey Kevin 
Published: May 2020

AbstractIntroduction:In August 2018, India’s southern state of Kerala experienced its worst flooding in over a century. This report describes the relief efforts in Kozhikode, a coastal region of Kerala, where Operation Navajeevan was initiated.Sources:Data were collected from a centralized database at the command center in the District Medical Office as well as first-hand accounts from providers who participated in the relief effort.Observations:From August 15 through September 8, 2018, 36,846 flood victims were seen at 280 relief camps. The most common cause for presentation was exacerbation of an on-going chronic medical condition (18,490; 50.2%). Other common presentations included acute respiratory infection (7,451; 20.2%), traumatic injuries (3,736; 10.4%), and psychiatric illness (5,327; 14.5%).Analysis:The prevalence of chronic disease exacerbation as the primary presentation during Operation Navajeevan represents an epidemiologic shift in disaster relief in India. It is foreseeable that as access to health care improves in low- and middle-income countries (LMICs), and climate change increases the prevalence of extreme weather events around the world, that this trend will continue.
The RhHB1/RhLOX4 module affects the dehydration tolerance of rose flowers (Rosa hybrida) by fine-tuning jasmonic acid levels
Authors: Fan Youwei , Liu Jitao , Zou Jing , Zhang Xiangyu , Jiang Liwei , Liu Kun , Lü Peitao , Gao Junping , Zhang Changqing 
Published: May 2020

AbstractPhytohormones are key factors in plant responsiveness to abiotic and biotic stresses, and maintaining hormone homeostasis is critically important during stress responses. Cut rose (Rosa hybrida) flowers experience dehydration stress during postharvest handling, and jasmonic acid (JA) levels change as a result of this stress. However, how JA is involved in dehydration tolerance remains unclear. We investigated the functions of the JA- and dehydration-inducedRhHB1gene, which encodes a homeodomain-leucine zipper I γ-clade transcription factor, in rose flowers. SilencingRhHB1decreased petal dehydration tolerance and resulted in a persistent increase in JA-Ile content and reduced dehydration tolerance. An elevated JA-Ile level had a detrimental effect on rose petal dehydration tolerance. RhHB1 was shown to lower the transient induction of JA-Ile accumulation in response to dehydration. In addition to transcriptomic data, we obtained evidence that RhHB1 suppresses the expression of the lipoxygenase 4 (RhLOX4) gene by directly binding to its promoter both in vivo and in vitro. We propose that increased JA-Ile levels weaken the capacity for osmotic adjustment in petal cells, resulting in reduced dehydration tolerance. In conclusion, a JA feedback loop mediated by anRhHB1/RhLOX4regulatory module provides dehydration tolerance by fine-tuning bioactive JA levels in dehydrated flowers.
95 Jahre Universitäts-Hautklinik Jena: Geschichte und Gegenwart
Authors: Reddersen K. , Burmester A. , Dieckmeyer C. , Engelmann C. , Goetze S. , Gregersen D. , Hipler U.-C. , Ludriksone L. , Peckruhn M. , Schliemann S. , Tittelbach J. , Wiegand C. , Elsner P. 
Published: May 2020

ZusammenfassungAnlässlich des 95-jährigen Jubiläums der Universitäts-Hautklinik Jena beleuchtet dieser Beitrag die historische Entwicklung des Hauses in den verschiedenen politischen Systemen des letzten Jahrhunderts sowie die aktuelle Situation der Klinik als Teil des Universitätsklinikums Jena. Verschiedene Klinikleitungen in der Vergangenheit prägten die Ausrichtung des Hauses in Bezug auf Therapie und Forschung und setzten Schwerpunkte auf Themen wie Phototherapie, Autoimmunerkrankungen, Dermatoonkologie, Andrologie und Biomaterialforschung. Die Universitäts-Hautklinik vereint neben hochqualitativer Patientenversorgung und Lehre umfangreiche Forschungsaktivitäten.
Der Einfluss von MS-spezifischen Symptomen auf die gesundheitsbezogene Lebensqualität
Authors: Sander Lydia , Kugler Joachim , Elsner Bernhard 
Published: May 2020

Zusammenfassung
Hintergrund Multiple Sklerose (MS) ist eine chronisch progredient verlaufende Erkrankung, welche mit einer Vielzahl von MS-spezifischen Symptomen einhergeht. Viele dieser Symptome wirken sich negativ auf die gesundheitsbezogene Lebensqualität (Health Related Quality of Life, HRQoL) der Betroffenen aus. Bisher ungeklärt ist, welche MS-spezifischen Symptome einen besonders großen Einfluss auf die HRQoL haben.
Methodik Die durchgeführte Untersuchung basiert auf den Daten einer Mitgliederbefragung der Deutschen MS Gesellschaft (DMSG) im Jahr 2015 (n = 424). Unter Berücksichtigung von soziodemographischen Variablen und allgemeinen medizinischen Variablen wurde der Einfluss der MS-spezifischen Symptome auf die HRQoL untersucht. Die HRQoL wurde mit dem Multiple Sclerosis Quality of Life-54-Instrument (MSQOL-54-Instrument) erhoben. In einem Vortest wurden alle Einflussfaktoren auf einen signifikanten Mittelwertunterschied (p = 0,05) bzw. eine mittlere Korrelation (Pearson’s r ≥ 0,3) getestet. Anschließend wurde der Einfluss der im Vortest identifizierten Variablen auf die HRQoL mithilfe der multiplen linearen Regressionsanalyse untersucht.
Ergebnisse Für die Befragten konnte ein durchschnittlicher Physical Health Composite Score (PHCS) von 48,3 (sd = 17,7) und ein durchschnittlicher Mental Health Composite Score von 56,0 (sd = 20,1) errechnet werden. Als wichtigste Einflussfaktoren auf die HRQoL ergeben sich die MS-spezifischen Symptome Depression, Schmerz und kognitive Einschränkungen. MS-bedingte Symptome mit einem Mobilitätskontext zeigen negativen Zusammenhang mit dem PHCS. Sprechstörung und Schwindel sind mit einem abnehmenden MHCS verbunden. Der Beschäftigungsstatus ist der einzige sozioökonomische Faktor, der sich in der multiplen Regression signifikant auf die HRQoL auswirkt. Die allgemeinen medizinischen Faktoren zeigen keinen signifikanten Einfluss auf die HRQoL.
Schlussfolgerung MS-spezifische Symptome haben einen großen Einfluss auf die HRQoL von Menschen mit MS. In der Untersuchung konnte gezeigt werden, dass besonders die sogenannten „versteckten Symptome“ einen wesentlichen Einfluss auf die HRQoL haben. Hier sind beispielsweise die Symptome Depression, Schmerz und kognitive Einschränkungen zu nennen. Diese sollten stärker in der Versorgung von Menschen mit MS berücksichtigt werden.
Factors Influencing the Choice between DOACs and LMWHs: A Survey of German Physicians on the Treatment of Cancer-Associated Venous Thromboembolism
Authors: Matzdorff Axel , Langer Florian 
Published: May 2020

AbstractRecently direct-acting oral anticoagulants (DOACs) have become a new therapeutic option besides parenteral anticoagulants to treat cancer-associated venous thromboembolism (VTE). With this survey we wanted to identify factors influencing the choice between low-molecular-weight heparin and DOACs among physicians treating cancer patients. A questionnaire was presented at several medical educational activities on cancer care and VTE management between August 2018 and January 2019. One hundred fifteen physicians returned their surveys. The two most compelling arguments pro DOAC were when the patient had no chemotherapy and when he expressed unwillingness to apply injections. The two most important arguments against DOACs were if the patient had problems with taking oral medications or when he had a history of severe bleeding. This survey shows that future studies need to consider many more factors, particularly patient preferences and physician concerns on bleeding risk, to improve their applicability in daily practice.
The Epidemiology of Traumatic Brain Injury Due to Traffic Accidents in Latin America: A Narrative Review
Authors: Dunne Jack , Quiñones-Ossa Gabriel Alexander , Still Ethne Grey , Suarez María N. , González-Soto José A. , Vera David S. , Rubiano Andrés M. 
Published: May 2020

Abstract

Objective Traumatic brain injuries (TBIs) are devastating injuries and represent a major cause of morbidity and mortality worldwide. Traffic accidents are one of the main causes, especially in low- and middle-income countries. The epidemiology of TBI due to road traffic in Latin America is not clearly documented.

Methods A narrative review was conducted using PubMed, SCOPUS, and Google Scholar, looking for TBI studies in Latin America published between 2000 and 2018. Seventeen studies were found that met the inclusion and exclusion criteria.

Results  It was found that TBI due to road traffic accidents (RTAs) is more frequent in males between the ages of 15 and 35 years, and patients in motor vehicles accounted for most cases, followed by pedestrians, motorcyclists, and cyclists.

Conclusion Road traffic accidents is a common cause of TBI in Latin America. More studies and registries are needed to properly document the epidemiological profiles of TBI related to RTAs.
Resveratrol Relieves Hyperoxia-Induced Brain Injury in Neonatal Rats by Activating Sirt1
Authors: Kang Lan , Dong Wenbin , Li Xiaobin , Ruan Ying , Zhang Rong 
Published: May 2020

Abstract
Objective Neonatal rats with hyperoxia-induced brain injury were treated with resveratrol to investigate its protective effects through analyzing changes in reactive oxygen species (ROS), Sirt1, p53, and acetylated p53 levels.
Study Design Neonatal rats were randomly divided into hyperoxia and resveratrol intervened groups. Rats in both groups were placed in a hyperoxia chamber for 7 days to induce hyperoxia-induced brain injury. The rats in the resveratrol intervened group were administered resveratrol 60 μg/g body weight daily, whereas those in the hyperoxia group were administered a dimethyl sulfoxide-based solvent. Brain tissues were collected, and hematoxylin and eosin (H&E) and TUNEL staining, ROS measurements, real time-polymerase chain reaction, and western blotting were performed.
Results H&E and TUNEL staining revealed increased cell damage and apoptosis in brain tissue from hyperoxia-exposed animals compared with the findings in animals in the resveratrol intervened group. Real time-polymerase chain reaction and western blotting identified increases in Sirt1 expression and decreases in p53 expression in the resveratrol intervened group. In addition, acetylated p53 protein expression was lower in the intervened group than in the hyperoxia group.
Conclusion Resveratrol alleviated brain apoptosis induced by hyperoxia in neonatal rats by upregulating Sirt1-mediated pathways, suggesting its potentially beneficial role in the treatment of brain injury induced by hyperoxia.
Extending the operation range of a phase-sensitive optical time-domain reflectometer by using fibre with chirped Bragg gratings
Authors: Kharasov D.R. , Bengalskii D.M. , Vyatkin M.Yu. , Nanii O.E. , Fomiryakov E.A. , Nikitin S.P. , Popov S.M. , Chamorovsky Yu.K. , Treshchikov V.N. 
Published: May 2020

Abstract
>A record long external-disturbance detection distance of 140 km without employing optical amplifiers in the fibre line is demonstrated by a phase-sensitive optical time-domain reflectometer (Φ-OTDR) using a fibre section with inscribed chirped fibre Bragg gratings (CFBGs). This solution provides simultaneous operation of Φ-OTDR with a standard single-mode fibre at a distance of up to 100 km and with a CFBG fibre section located from the fibre line input point by at least 140 km.
Allosteric conformational change of a cyclic nucleotide-gated ion channel revealed by DEER spectroscopy
Authors: Evans Eric G. B. , Morgan Jacob L. W. , DiMaio Frank , Zagotta William N. , Stoll Stefan 
Published: May 2020

Significance
Cyclic nucleotide-gated (CNG) and hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels generate the primary electrical signals underlying mammalian phototransduction, olfaction, and cardiac pacemaking. These channels activate upon binding of cyclic nucleotide ligands (cAMP and/or cGMP), but the allosteric mechanism that couples ligand binding to gating is not well understood. Using double electron-electron resonance (DEER) spectroscopy, we reveal an allosteric conformational transition in the bacterial CNG channel SthK upon cAMP binding that involves outward movement of the C-linker domain in relation to the pore axis. Computational models constrained by DEER data also predict an upward movement of the cytoplasmic domain toward the membrane and suggest key interactions that may stabilize the agonist-induced conformational change.