bluuebunny/crossref_metadata_2025_split huggingface dataset:
In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers
Authors: Bell David R. , Weber Jeffrey K. , Yin Wang , Huynh Tien , Duan Wei , Zhou Ruhong 
Published: March 2020

SignificanceEpithelial cellular activating molecule (EpCAM) is vastly overexpressed in tumor cell membranes of certain carcinomas, and thus represents an auspicious clinical target for cancer therapies. To date, therapeutic targeting of EpCAM has principally involved antibodies; smaller, nucleic-acid based aptamers have shown great promise, but have not yet reached clinical application. Here, using experimentally validated in silico techniques, we have designed two RNA aptamers that bind EpCAM with improved affinity over existing aptamers. We confirm that these aptamers bind the EpCAM dimer, a complex distinct from and more physiologically relevant than the oft-targeted EpCAM monomer. This successful structure-based in silico approach advocates for the broad use of such methods in RNA aptamer design.
Securing timelines in the ancient Mediterranean using multiproxy annual tree-ring data
Authors: Pearson Charlotte , Salzer Matthew , Wacker Lukas , Brewer Peter , Sookdeo Adam , Kuniholm Peter 
Published: March 2020

Significance
This study demonstrates how different lines of evidence from tree rings in widely spread growth locations can combine to fix an approximately dated tree-ring record from the East Mediterranean Bronze–Iron Age to an exact calendar-dated range. This tree-ring record is of high importance for regional chronology and spans the time period in which the major volcanic eruption of Thera (Santorini) occurred. Exact dating of this eruption is important because it provides a prominent marker horizon through which ancient timelines of the East Mediterranean, Egypt, and the Levant can be synchronized. Chemical analysis of the dated tree-ring sequence identifies a chemical change in their growth environment around 1560 BC, which while requiring further substantiation, may be evidence of the Thera eruption.
Nonclassical nuclear localization signals mediate nuclear import of CIRBP
Authors: Bourgeois Benjamin , Hutten Saskia , Gottschalk Benjamin , Hofweber Mario , Richter Gesa , Sternat Julia , Abou-Ajram Claudia , Göbl Christoph , Leitinger Gerd , Graier Wolfgang F. , Dormann Dorothee , Madl Tobias 
Published: March 2020

Significance
We uncovered a molecular mechanism by which multiple importins regulate nuclear import, phase separation, and stress granule recruitment of an RNA-binding protein. Our work permitted the identification of two types of nuclear localization signal (NLS) in cold-inducible RNA-binding protein (CIRBP). We show that CIRBP, which lacks any classical NLS, binds both the importin Transportin-1 (TNPO1) and Transportin-3 (TNPO3). These interactions and nuclear import of CIRBP involve two distinct CIRBP regions, the arginine-glycine(-glycine) (RG/RGG) region and the discovered arginine-serine-tyrosine (RSY)–rich region. We show that these two regions harbor different specificity toward TNPO1 and TNPO3, with the RG/RGG-NLS being specialized in TNPO1 recognition and the RSY-NLS being specialized in TNPO3 recognition.
Influences of language input and production on the language skills of Persian-English bilingual immersion preschool children
Authors: Payesteh Bita , Finestack Lizbeth H. 
Published: March 2020

Abstract
The purpose of this study was to better understand bilingualism in Persian-English preschool-aged children, and
how their language performance across two domains of language related to their language production and parental language
input. Participants were 15, 2- through 5-year old Persian-English bilingual children attending a Persian immersion preschool in
the U.S. The participants completed a battery of language tasks in English and Persian and participants’ parents provided language
input and production information. Data indicate that greater input in the heritage language outside school, Persian, will likely
lead to better Persian skills, while greater English input may negatively affect the children’s Persian skills. Participants
received consistent native-level Persian input in school, yet the results suggest that Persian as a heritage language in the U.S.
may be susceptible to the same vulnerability that affects other non-mainstream languages.
Progress of nanopositioning and nanomeasuring machines for cross-scale measurement with sub-nanometre precision
Authors: Manske E , Fröhlich T , Füßl R , Ortlepp I , Mastylo R , Blumröder U , Dontsov D , Kühnel M , Köchert P 
Published: March 2020

Abstract
Nanopositioning and nanomeasuring machines (NPM-machines), developed at Technische Universität Ilmenau, have provided high-precision measurement and positioning of objects across ten decades, from 20 pm resolution up to 200 mm measuring range. They work on the basis of the error-minimal, extended six degrees of freedom Abbe-comparator principle, with high-precision fibre-coupled laser interferometers and optical or atomic force probes. These machines are suitable not only for measuring but also for positioning with an outstanding sub-nanometre performance.
Measurements on precision step heights up to 5 mm show a repeatability of 20 pm. Consecutive step positioning of 80 pm can be demonstrated. With the new approach of an atomic clock-stabilized He–Ne-laser via a high-stable-frequency comb, we achieve a frequency stability of less than 300 Hz, respectively 0.6 ċ 10−12 relative frequency stability within 1 h at an integration time of 1 s. For the first time, we can demonstrate a direct, permanent and unbroken chain of traceability between the laser interferometric measurement within an NPM-machine and a GPS satellite-based atomic clock. This paper presents a closer insight into the scientific and metrological background as well as unrivalled measurement results, and discusses the great possibilities of this new technology.
Revisiting the detection rate for axion haloscopes
Authors: Kim Dongok , Jeong Junu , Youn SungWoo , Kim Younggeun , Semertzidis Yannis K. 
Published: March 2020

The cavity haloscope has been employed to detect microwave photons resonantly converted from invisible cosmic axions under a strong magnetic field. In this scheme, the axion-photon conversion power has been formulated to be valid for certain conditions, either Q
cavity ≪ Q
axion or Q
cavity ≫ Q
axion. This remedy, however, fails when these two quantities are comparable to each other. Furthermore, the noise power flow has been treated independently of the impedance mismatch of the system, which could give rise to misleading estimates of the experimental sensitivity. We revisit the analytical approaches to derive a general description of the signal and noise power. We also optimize the coupling strength of a receiver to yield the maximal sensitivity for axion search experiments.
Effect of calcination temperature on catalyst performance in landfill leachate treatment
Authors: Shi Liang , Zhuang Mingjie , Zhang Yongli 
Published: March 2020

Abstract
In this study, the landfill leachate was treated by Catalytic wet air oxidation, and the heterogeneous catalyst Fe-Co-Ru-Ce/γ-Al2O3 was prepared. The calcination temperatures were respectively set at 300, 450, 600, 750 and 900 °C, and the Fe-Co-Ru-Ce/γ-Al2O3 impregnated with the four metal salt solutions was calcined at the set temperature for 3 h to study the effect of calcination temperature on the activity of the catalyst.The results showed that when the calcination temperature was 450 °C, the activity of the catalyst reached the maximum. At this time, the COD removal rate, decolorization rate and turbidity removal rate of the treated water samples were the highest, which were 78.1%, 60.4% and 92.7%, respectively.
Performance and Parameter Optimization of Self-piercing Riveted Joint for Aluminum Alloy Plate
Authors: Zhong Jiabin , Zhang Yihuai , Shi Baijun 
Published: March 2020

Abstract
Self-piercing riveting is a connection technology to achieve efficient connection of aluminum alloy plates, and the quality of the connection mainly depends on the rivet and mold parameters. This paper establishes a self-piercing riveting simulation analysis model based on the ALE method, and verifies the accuracy of the model by comparing the simulation and experimental results. Five parameters such as rivet length and mould radius are selected, and the undercut amount, bottom thickness, remaining thickness, and tensile shear capacity are used as evaluation indexes to research the main factors that affect the joint forming quality, and an effective optimization scheme is proposed.
Experimental study on a new type of cutting fluid based on hexadecyl dimethyl-ammonium bromide
Authors: Yang Yong , Xiong Li , Li Ang 
Published: March 2020

Abstract
The theory of superlubricity brings a new idea and direction to solve the problem of wear and tear of high-speed cutting tools. According to the superlubricity theory, a new type of cutting fluid based on hexadecyl dimethyl-ammonium bromide was developed by combining superlubricity agent and cutting fluid. Furthermore, taking the cutting of titanium alloy as the object, high speed cutting tests of the new type of cutting fluid were carried out. Finally, a large number of comparative analyses were carried out based on the experimental results. The research shows that the new type of cutting fluid has better cooling and lubrication effect, and can play a good role in reducing friction of cutting tool and improving surface quality of workpiece. The optimum concentration range of hexadecyl dimethyl-ammonium bromide is 2%-4%.
Research progress on application of spray-type damping coating
Authors: Lin Chong , Shi Lei , Zhang Ling , Wang Bing , Cheng Wei 
Published: March 2020

Abstract
This paper analyzes the current control requirements of mechanical vibration and noise in the fields of ships. The author briefly introduces the working principle and main classification of damping coatings, and describes the current domestic and international aspects from the types of spray-type damping coatings and spraying processes. The research progress and application of spray-type damping coatings such as asphalt damping coating, PVC based damping coating, polyurethane based damping coating, waterborne acrylic based damping coating and IPN damping coating and metal alloy coating are reviewed. The development trend and application considerations are summarized in this paper at last.
Study on the preparation and modification of chalcogenide MoS2
Authors: Chen Xueman , Shi Liang , Zhang Yongli , Wang Junfei 
Published: March 2020

AbstractTwo-dimensional material MoS2is another research hotspot following the layered compound graphene. MoS2has the advantages of low cost, non-toxicity, large specific surface area, high reaction activity and good photocatalytic effect. In this paper, the preparation methods of MoS2are reviewed. They are mainly divided into top-down method, bottom-up method and the modification methods including morphology control, co-catalyst combination, non-metallic or metal doping, phase transition and crystal shape adjustment adopted by researchers to solve the problems of MoS2which is easy to accumulate and the high composite ratio of photogenerated electrons and holes.
Measurement of Thermal expansion coefficient of solid Materials by double slit Interferometric method
Authors: Hao Xiulu , Yang Guijuan , Wang Lina , Tang Delong , Zhou Dan , Mei Yan 
Published: March 2020

Abstract
Thermal expansion coefficient is a regular coefficient to describe the variation of geometric characteristics of matter under the action of thermal expansion and cold shrinkage effect, and it is an important index to measure the thermal stability of materials. A device for measuring the thermal expansion coefficient of solid materials by Yang’s double slit interferometric method with variable double slit spacing is mainly composed of laser, sliding Young double slit structure, temperature measuring and controlling instrument, shading tube, receiving device and solid material to be measured. The solid material is heated by ring heater, the temperature of solid material is displayed and controlled by temperature measuring and controlling instrument, and the change of stripe spacing is recorded by linear CCD image sensor. Compared with the traditional optical leverage method, this measuring device and method can significantly improve the accuracy of the measurement results and reduce the uncertainty of the measurement results.
Experiment Research on the Mechanical Performance of Alkali-activated Slag Cementitious Material
Authors: Su Qing , Tao Zhixiong 
Published: March 2020

Abstract
The influence of three different kinds of alkali (sodium hydroxide, sodium sulfate and water glass) excitation agents on the mechanical properties of slag cement materials has been studied by compressive test. The results show that the effect of excitation of sodium silicate is better than that of sodium hydroxide and sodium sulfate, with the increase of alkali equivalent excitation agent, compressive strength of mortar specimens remarkably, compared with alkali equivalent of 3.1% of the sodium sulfate, the 28d compressive strength of mortar specimens with alkali equivalent of 4.65% and 6.2%, has been increased by 140% and 31.5% respectively.
Optical properties of hybrid quasiperiodic Fibonacci photonic crystals
Authors: Zhong Yibing , Shi Shengli , Gao Mingxing , Wang Yuhao , Lv Chunyan , Dong Daxing 
Published: March 2020

Abstract
In this paper, we exploit new optical properties of hybrid quasiperiodic Fibonacci photonic crystals by the transfer matrix method. The quasiperiodic photonic crystals are consist of various generation orders of photonic crystal series that follow the Fibonacci sequence. By regarding the building blocks like S
3, S
4, S
5 as a unit cell (S
3
S
4
S
5) of photonic crystals, we get multiple bandgaps in its spectrum. Furthermore, the bandgaps of the Fibonacci hybrid photonic crystals are tunable by merely altering the refractive index of the dielectric materials. The proposed configuration is a promising candidate as a multichannel filter and a refractive index sensor in the field of integrated photonic circuits.
Suspended-ultrathin Si membrane on SOI: a novel structure to reduce thermal stress of GaN epilayer
Authors: Song Yuzi , Wang Kejia , Du Pengwei , Cheng Zhiyuan 
Published: March 2020

Abstract
A 30nm-thick suspended-ultrathin silicon membrane based on SOI (silicon-on-insulator) substrate for GAN epitaxial growth is fabricated and analysed. We demonstrate that thermal stress of GaN in the effective area on this novel substrate can be reduced 44% more than that in normal SOI substrate, which can reduce the dislocation and crack density in GaN. The absence of BOX (buried oxide) layer are confirmed as main factors to result in reduction of thermal stress in GaN layer. This work provides a promising approach to obtain high-quality GaN by utilizing mechanical structure.
Influence of ubiquitiform complexity on fracture energy of concrete
Authors: Ju Yibo , Ou Zhuocheng , Duan Zhuoping , Huang Fenglei 
Published: March 2020

Abstract
The crack extension path of concrete materials was simulated numerically based on the non-uniform numerical model of Weibull distribution, and the complexities of various ubiquitiform fracture surfaces were calculated to explore the relationship between complexity and fracture energy. To study the influence of specific crack extension law and fracture mode on the relationship between the complexity and fracture energy, numerical simulation of the crack extension was carried out based on the numerical model with random aggregate distribution, and the reason for the change of the relationship between complexity and fracture energy were discussed.
Experimental study on three-point bending performance of CFRP shaft embedded FBG sensor
Authors: Wang Xianfeng , Li Wang , Ding Guoping , Yan Xiaoyu , Yue Shengyuan 
Published: March 2020

Abstract
The bending deformation of Carbon Fiber Reinforced Polymer (CFRP) shaft is one of the important indicators reflecting its performance. Monitoring the deformation of CFRP shaft under different loads is of great significance for the optimal design of CFRP shaft. Fiber Bragg Grating (FBG) sensor is small in diameter, easy to be embedded inside the CFRP shaft, which has little influence on the structure itself. In addition, it can realize "one fiber multi-point" measurement, which is very suitable for the internal monitoring of anisotropy composites. This paper proposes a pre-embedded FBG sensor to monitor CFRP shaft strain. Prepared CFRP shaft test piece. Four FBG sensors are embedded inside the shaft, and four FBG sensors and four strain gauges are pasted on the surface of the shaft. The CFRP shaft was subjected to three-point bending loading on a universal testing machine. The strain data obtained by FBG sensor and strain gauge under various loads were compared and analyzed. The feasibility and accuracy of the embedded FBG sensor to monitor CFRP shaft strain were verified.
Microstructure and mechanical properties of Hastelloy-X produced by selective laser melting
Authors: Zhang Dayue , Wang Shaolin , Zhang Hualiang , Tan Chunqing , Gao Qing , Liu Xiyang , Cui Zhaowen 
Published: March 2020

Abstract
The microstructure including defects and mechanical properties of as-deposited and heat treated (HT) Hastelloy-X manufactured by selective laser melting (SLM) technology were studied, in order to apply this technique into the manufacturing of gas turbine components. The processing parameters, including scan speed, laser power, scan spacing, and linear energy density were optimized to obtain less porosity. Heat treatment at different temperatures and times was executed to modify the microstructure and reduce the residual stress. When the linear laser energy density increased (>0.12 J/mm), the porosity decreased to ~0.5 %. By decreasing scan spacing to 0.06 mm, the porosity was further decreased to 0.2 %. With increased HT temperature, the microstructure changed from columnar grains through partial recrystallized grains to fully recrystallized coarsened equiaxed grains. Hardness decreased with increasing HT temperature and time in the HT conditions mainly due to grain coarsening and carbide reduction.
Experimental study on tensile properties of steel casing welding
Authors: Zhu Zhenyu , Yang Yi 
Published: March 2020

Abstract
In order to study the tensile properties of steel casing welding, static tensile tests were carried out on 12 welded specimens.The load-displacement curve was obtained, and its bearing capacity, yield strength and tensile strength were studied.The test results show that this method is a feasible welding method. The tensile properties of the test piece are similar to those of the base metal, and the fracture is ductile fracture.
Comparison of soil classification methods among domestic and oversea based on CPTU test
Authors: Wang Junpeng , Wang Bingkang 
Published: March 2020

Abstract
This article presents the comparison of two soil classification methods among domestic and oversea based on CPTU test in geotechnical practice of soft deposit subgrade. Although CPTU test exists earlier in the world, However, CPTU test has been not applied in geotechnical practice of road subgrade until in recent years in China. Two soil classification methods among domestic and oversea are applied to soil classification and differences of them are analyzed.
Study on tensile properties of rice straw rope considering degradation
Authors: Tang Peng , Qi Yongzheng , Ding Yu-xuan , Hao Zijin , Xu Guizhong 
Published: March 2020

Abstract
Many scholars have used crop straw to reinforce soft soil foundation and studied its reinforcement effect and mechanism. However, the crop straw will degrade in the soil for a long time, which reduces the tensile strength of the straw and weakens the shear resistance of the reinforced soil. In order to study the degradation law of rice straw rope and its influence on tensile properties, the straw rope was immersed in water for different time, and then taken out, the quality before and after immersion was measured and tensile test was carried out. The results showed that: the degradation of rice straw rope in water experienced two stages of rapid degradation and slow degradation, and the quality of loss in the rapid degradation stage was more; the tensile force of straw stalk rope increased slowly with the increase of tensile displacement. When immersed for 20 days, the failure mode was brittle failure, and after 40 days of immersion, the failure mode changed into ductile failure; the straw stalk rope was the main tensile force of the straw fiber, and the tensile strength peak decreased with the increase of the immersion time. The deterioration law accorded with the third-order polynomial function.
Tree 101 block CO2 Minimum miscibility pressure slim tube test
Authors: Liu Li , Pi Yanfu , Liu Yingjie , Zhou Shixin , Guo Xuan , Wang Dewei , Meng Zetian 
Published: March 2020

Abstract
Determining the minimum miscibility pressure is the main research content of CO2 mixed phase displacement. It is a key indicator of whether the formation fluid can reach the miscible phase. There are many ways to determine the minimum miscibility pressure. At present, the laboratory test measures the minimum miscibility pressure of CO2-crude oil. The accepted industry standard is the slim tube test. This paper is aimed at the reservoir profile of Tree 101 block in Yushulin Oilfield. Carry out a slim tube test to determine the minimum miscibility pressure of 32.43MPa.
A study of spectral behaviors of turbulent wall-pressure fluctuations
Authors: Wang Jie , Yu Jiao , Zhu Yanying , Guo Kaixuan 
Published: March 2020

AbstractTurbulent wall-pressure fluctuations are major sources of noise and their numerical calculations have been important topics in engineering fields. In this paper, large eddy simulation is conducted to study spectral behaviors of turbulent wall-pressure fluctuations. The roughness was simulated by using an array of 10 off-set square columns extending in the vertical directions on the bottom surface, and local downstream aerodynamic fields were numerically investigated. The wind speed fluctuations in the flow field and the pressure fluctuations at the bottom of the flow field are monitored at a certain cross-section when varying square column heights and wind turbulence conditions at the wind speed inlet. Frequency spectral characteristics are analysed and the influence factors of wall-pressure fluctuations are explored.
Study on lithology identification method of carboniferous in the west wing chepaizi salient in western margin of junggar basin
Authors: Wang Yong , Kong Xiangchao , Tang Dong , Li Jing , Zhang Hansheng 
Published: March 2020

Abstract
Reservoir characteristics are important indexes for oil and gas exploration and development. Therefore, the identification of igneous lithology of target formation is carried out by using intersection diagram and mechanical parameter method according to the Carboniferous logging data of the west wing chepaizi salient in western margin of junggar basin. The results show that the study area is dominated by volcanic clastic rocks and sedimentary rocks. The cross-section and mechanical parameters method can be used to identify the lithology and obtain the corresponding physical parameters. Finally, this work has guiding significance for the exploration and development of Carboniferous reservoirs in the west wing chepaizi salient in western margin of junggar basin.