bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manipulation of Diet Intake and Milk Production of Red Sindhi Cows by Varying the Water and Feeding Frequencies
Authors: Khaskheli A.A. 
Published: December 2020

Background: Current research was carried out at Red Sindhi farm, Tando Muhammad Khan, during the year 2018, in order to manipulate the diet intake and milk production of Red Sindhi cows by varying the water and feeding frequencies.Methods: A total of 300 Red Sindhi cows under 3rd lactation were selected and were divided into 5 groups. Cows in group A (control) were offered ad-libitum feed and water, in group B; 2 time feed (Morning 6:00AM and 6:00PM) and ad-libitum water, in group C; 3 times feed (6:00AM, 2:00 Noon and 10:00PM) and ad-libitum water, in group D, ad libitum feed and 2 times water (6:00AM and 6:00PM), in group E; ad libitum feed and 3 times water (6:00AM, 2:00 Noon and 10:00PM). Result: Results of present study indicated that the daily water intake was found significantly maximum (47.00±1.45) in group B and minimum (43.33±0.88) in group D. Statistically significant difference was seen in group D compared to other groups, while no significant difference among groups A, B, C and E. Maximum daily feed intake (19.66±2.40) was recorded in group A and minimum daily feed intake (15.00±0.57) was recorded in group B. There was significant difference in daily feed intake in group E with groups A and B. However there was no significant difference in daily feed intake between groups A and B as well as groups C, D and E, correspondingly. Maximum weekly milk production (40.00±1.45 kg) was recorded in group A and minimum milk production (34.00±0.88 kg) was recorded in group B. However there was significant difference in milk production among groups A and B, while non-significant difference between groups C and D as well as A and E, correspondingly.Conclusion: In conclusion, Red Sindhi cows produced significantly higher milk under group A (control) offered 24 hours water and ad-libitum feed compared to all other groups.
Campos de vuelo : el nuevo papel de los viejos aeropuertos = Airfields : a new role for the old airports
Authors: Pico Valimaña Ramón A. 
Published: December 2020

ResumenEste es un artículo en dos tiempos, mediados por un entreacto, en los que naturaleza, ciudad y aviación se entrecruzan. El primero de ellos, centrado a finales de los años veinte del siglo pasado, describe un momento de emoción en el que los primeros aeródromos servirán a geógrafos, artistas y arquitectos como plataformas desde las que explorar las relaciones entre ciudad y naturaleza. El segundo tiempo nos sitúa en la actualidad y lanza sus preguntas al futuro. Un momento en que los paisajes en secuencia, evolutivos, marcan la tendencia en el tratamiento de las instala­ciones aeroportuarias obsoletas, revirtiendo gran parte de sus tierras al campo original y difumi­nando las trazas de su etapa aérea. La experiencia de Robert Smithson en Pine Barrens define el entreacto, subrayando la sensi­bilidad del artista en la apreciación del vacío del aeródromo como un lugar singular, cargado de valores sensoriales y patrimoniales.AbstractThis is an article in two stages, mediated by an intermission, where nature, city and aviation intersect. The first one, focussed in the late twenties of the last century, describes a moment of emotion in which the first airfields will serve geographers, artists and architects as platfor­ms from which to explore the relationship between city and nature. The second places us today and throws questions into the future. A moment in which the sequential, evolutionary landscapes mark the trend in the treatment of obsolete airport facilities, reversing much of their land to the original field and blurring the traces of their aerial stage. The experience of Robert Smithson in Pine Barrens defines the intermission, underlining the artist’s sensitivity in appreciating the emptiness of the airfield as a unique place, loaded with sensory and heritage values.
Investigating the validity and reliability of the traditional checklist for assessment of specific inhalation techniques with pressurized metered-dose inhalers using the Aerosol Inhalation Monitor
Authors: Lin Tzu-Yu , Yan Dah-Chin , Wang Yi-Jung , Liang Yu-Ting , Chen Tun-Liang 
Published: December 2020

Abstract
Background: Correct inhalation techniques are essential for optimum delivery of drugs to the airways for patients with asthma and chronic obstructive pulmonary disorder. Checklists often are used to assess the techniques, but the validity of checklists is unknown and few studies have been conducted to date. We investigated the validity and reliability of checklists.Methods: A prospective, observational study was conducted at a tertiary care teaching hospital in Taiwan using an objective tool, the aerosol inhalation monitor (AIM). Inhalation techniques using pressurized metered-dose inhalers (pMDIs) were assessed by checklist and AIM. The κ coefficient and prevalence and bias-adjusted κ (PABAK) were calculated to determine the consistency between the checklist and AIM in four specific techniques, including actuation, inspiratory flow, inhalation time, and breath hold time. Sensitivity and specificity were used to evaluate the validity of the checklist using these techniques.Results: The κ and PABAK values were −0.023 and −0.176 for actuation, 0.43 and 0.529 for inspiratory flow, −0.046 and −0.412 for inhalation time, and 0.12 and 0.686 for breath hold time, respectively. Sensitivity and specificity for the four individual steps were 0.706 versus 0.265, 0.833 versus 0.600, 1 versus 0.1, and 0.955 versus 0.143, respectively.Conclusion: Our results invalidate use of the checklist alone as a reliable tool to assess inhalation techniques. The low specificity indicates that the checklist tends to overestimate the accuracy of inhalation techniques. AIM can be added as an objective tool to assess and quantify specific steps for MDIs.
Pregnant Women's Perspectives on Integrating Preventive Oral Health in Prenatal Care.
Authors: Adeniyi Abiola , Donnelly Leeann , Janssen Patricia , Jevitt Cecilia , Kardeh Bahareh , vonBergmann HsingChi , Brondani Mario 
Published: December 2020

Abstract
Background: Oral diseases are considered a silent epidemic including among pregnant women. Given the prevalence of oral conditions among pregnant women and the reported association with adverse pregnancy outcomes, there have been suggestions for the inclusion of preventive oral care in routine prenatal care. However, due to the different administrative and funding structure for oral health and prenatal care in Canada, progress towards this integration has been slow. Our study sought to qualitatively explore the views of pregnant women in British Columbia (BC) on the strategies for integrating preventive oral health care into prenatal care services.Methods: A qualitative approach was utilized involving semi-structured interviews with fourteen (14) purposefully selected pregnant women in Vancouver and Surrey, BC. The interviews were audio-recorded and transcribed. The transcripts were analyzed using an inductive thematic approach. Study validity was ensured via memoing, field-notes, and member checking.Results: Interviews ranged from 28 to 65 minutes producing over 140 pages of transcripts. Analysis resulted in three major themes: oral health experiences during pregnancy, perspectives on integration and integrated prenatal oral care, and strategies for addressing prenatal oral health care. A majority of participants were supportive of integrating preventive oral care in routine prenatal services, with referrals identified as a critical strategy. Oral health education was recognized as important before, during, and after pregnancy; oral health assessments should therefore be included in the prenatal care checklist. Limited funding was acknowledged as a barrier to oral health care access, which may explain why few participants visited their dentists during pregnancy. Interprofessional education surfaced as a bridge to provide prenatal oral health education.Conclusion: Pregnant women interviewed in this study support the inclusion of educational and preventive oral care during prenatal care, although their views differed on how such inclusion can be achieved in BC. They advocated the establishment of a referral system as an acceptable strategy for providing integrated prenatal oral health care.
Factors Predicting the Physical Activity Behavior based on Theory of Reasoned Action among Chronic Low Back Pain of the Patients Referring to Comprehensive Health Service Centers in the Shahid Beheshti University of Medical Sciences in Tehran, Iran.
Authors: Delshad Mohammad , Hidarnia Alireza , Pourhaji Fatemeh 
Published: December 2020

Abstract
Background: Low-level physical activity (PA) among Chronic Low Back Pain (cLBP) is associated with various biopsychosocial factors. This research aimed to study the predictors of PA behavior among cLBP patients. Methods: In the present study 300 eligible patients with cLBP who referred to comprehensive health service centers in the Shahid Beheshti University of Medical Sciences (SBUMS) in Tehran, Iran were random selected.To diagnose the predictors of PA behavior, all the Theory of Reasoned Action (TRA) constructs were examined as risk factors to see if they influence on the probability of PA behavior occurrence and were interpreted through odds ratio (OR). SPSS version 19 was used to analyze the data. Results: Totally 280 cLBP patients with mean age of 57.07 ±13.09 years old participated in the study. This study showed that motivation to comply significant predictor the cLBP patients for subjective norm OR (%95CI): 2.095(0.116-2.792), p-value<0.001), intention was significant predictor for perform the PA behavior OR (%95CI): 1.431(0.138-1.538), p-value <0.001), behavior beliefs could predictor for attitude OR (%95CI): 1.276(0.106-1.355), p-value= 0.002). attitude, normative beliefs, subjective norm ,and evaluation outcome behavior could predictors the cLBP patients for intention to perform the PA behavior OR (%95CI): 1.188(0.032-1.312), p-value<0.001)., OR (%95CI): 1.158(0.076-2.208), p-value=0.003) ., OR (%95CI): 1.104(0.076-1.128), p-value<0.001) ., OR (%95CI): 0.814(0.301-1.440), p-value=0.007). Conclusions: This study showed that the cLBP patients who were normative beliefs and evaluation regarding PA behavior could effect on the intention to engage in greater PA than those via other constructs (attitude and subjective norm).
Determinants of&nbsp;Diabetes Ketoacidosis Among Diabetes Mellitus patients at North Wollo and Waghimra Zone Public Hospitals, Amhara Region, Northern Ethiopia
Authors: Getie Addisu , Wondmieneh Adam , Bimerew Melaku , Gedefaw Getnet , Demis Asmamaw 
Published: December 2020

Abstract
Background: Diabetes Mellitus (DM) is a metabolic disorder associated with acute nonmetabolic and metabolic complications. Diabetic ketoacidosis is the most serious diabetic emergency in patients with diabetes mellitus. It is the leading cause of mortality in children and young adults. Even though the burden of diabetes ketoacidosis has increased over the past years in Sub-Saharan Africa, no research has been conducted on the determinants of Diabetes ketoacidosis in Ethiopia, particularly in the Amhara region. Thus, this study aimed to identify the determinants of diabetes Ketoacidosis among Diabetes Mellitus patients at North Wollo and Waghimra Zone public Hospitals.Methods: An institution-based unmatched case-control study design was employed on 408 patients (102 cases and 306 controls) at North Wollo and Waghimra Zone Public Hospitals from March 1st to April 30th, 2020. A consecutive sampling method was used to select study participants. The data were collected using structured interviewer-administered questioners and reviewing of patient charts. The analysis was done using a binary logistic regression model. Then, P-value < 0.05 was considered statistically significant.Result: The mean (±SD) age of the study participants was 46.96 (± 15.175 SD) years. Irregular follow-up in diabetes clinic (AOR:4.19, 95% CI :2.28-7.71), not received diabetic education (AOR: 2.87, 95% CI:1.44-5.72), alcohol drinking (AOR:2.99, 95% CI :1.46-6.12), discontinuation of medications (AOR: 4.31, 95% CI:1.92-9.68), presence of comorbidity (AOR:2.57, 95% CI :1.37-4.84), and being type one of diabetes mellitus (AOR: 2.01, 95% CI:1.11-3.63) were determinant factors of diabetic ketoacidosis . Conclusions: This study showed that the behavioral and clinical characteristics of diabetic patients were risk factors of diabetic ketoacidosis. Follow-up in the diabetic clinic, diabetic education, discontinuation of medications, alcohol drinking, presence of comorbidities, and type of diabetes mellitus were independent determinants of diabetic ketoacidosis.
Application of the Distraction Support in Intramedullary Nailing&nbsp;Treatment for Tibial Shaft Fracture: A Randomized Controlled Study
Authors: Yao Liwei , Mao Haijiao , Wu Zeting , Xu Dingli , Dong Wenwei 
Published: December 2020

Abstract
Purpose The aim of this study is to investigate the effectiveness of using a new distraction support in intramedullary nailing treatment for tibial shaft fracture.Methods: Patients at the trauma center who underwent the treatment for tibial shaft fractures from July 2013 to December 2018 were enrolled. The patients were randomized in control group(n=43) and distraction support(SD) group(n=42). All operations were performed by the same senior surgeon. The hospital day, blood loss, operative time, infect rate, delayed union rate and malalignment rate(p=0.68) were obtained for the evaluation.Results: 85 participants were recruited and all cases were achieved the acceptable reduction. The operative time was significantly shorter for DS group than control group (75.3 vs.90.4 p<0.001). Blood loss was significantly lower in the DS group compared to the control group(60.1vs.85.4 p=0.003) . There were no obvious difference about infect rate(p=0.98), delay union(p=0.45), hospital days(p=0.37) and malalignment rate(p=0.68) between the two groups.Conclusion: Distraction support was effective in intramedullary nailing surgery. The application of distraction support may be a useful method in our future work.
Individual Quality of Life and the Environment – Towards a Concept of Liveable Areas for Persons with Disabilities in Poland
Authors: Grabowska Izabela , Antczak Radosław , Zwierzchowski Jan , Panek Tomasz 
Published: December 2020

Abstract
BackgroundThe United Nations Convention on the Rights of Persons with Disabilities highlights the need to create proper socio-economic and political conditions for persons with disabilities, with a special focus on their immediate living conditions. According to the Convention, these conditions should be built to ensure that persons with disabilities have the potential to enjoy a high quality of life (QoL), and this principle is reflected in the notion of liveable areas. The crucial aspect of this framework is the relationship between the individual QoL and the environment, broadly understood as the socio-economic as well as the technical conditions in which persons with disabilities function.MethodsThe basic research problem was to assess the relationship between individual QoL for the population with disabilities as a dependent variable and liveability indicators as independent variables, controlling for individual characteristics. The study used a dataset from the EU-SILC (European Union Statistics on Income and Living Conditions) survey carried out in 2015 in Poland. The research concept involved several steps. First, we created a variable measuring the QoL for the entire population with disabilities. To measure the multidimensional QOL, we used Sen’s capability approach as a general concept, which was operationalised by the MIMIC (multiple indicators multiple causes) model. In the second step, we identified the liveability indicators available in the official statistics, and merged them with survey data. Finally, in the last step, we ran the regression analysis. We also checked the data for the nested structure.ResultsWe confirmed that environmental conditions, defined as all conditions focused on creating liveable areas, played a significant role in shaping the QoL of persons with disabilities, and that this relationship held even after controlling for the demographic characteristics of the respondents. Moreover, we found that in addition to the general environmental conditions, the conditions created especially for persons with disabilities affected the QoL of these individuals. ConclusionsThe results illustrate the need to strengthen policies aimed at promoting the QoL of persons with disabilities by creating access to community assets and services that can contribute to improving the life chances of this population.
Evaluation of A Novel Particle-Based Multi-Analyte Technology for the Detection of Anti-Fibrillarin Antibodies
Authors: Mahler Michael , Kim Grace , Roup Fabrece , Bentow Chelsea , Fabien Nicole , Goncalves David , Palterer Boaz , Fritzler Marvin J , Villalta Danilo 
Published: December 2020

Abstract
Objective: Systemic sclerosis (SSc) is a heterogeneous autoimmune disease associated with several anti-nuclear antibodies (ANA), including those in the classification criteria [anti-centromere, anti-topoisomerase I (Scl-70), anti-RNA Pol III]. However, the presence of less common antibodies such as anti-fibrillarin (U3-RNP), that generate a clumpy nucleolar pattern by HEp-2 indirect immunofluorescence assay (IFA, ICAP AC-9), are considered disease specific and are with clinical subsets of SSc, therefore playing a role in diagnosis and prognosis. A specific and sensitive anti-fibrillarin assay would be an important addition to serological diagnosis and evaluation of SSc. The goal of this study was to evaluate a new particle-based multi-analyte technology (PMAT) for the measurement of anti-fibrillarin antibodies Methods: A total of 149 patient samples were collected including 47 samples from France (Lyon and Paris, n=32) and Italy (Careggi Hospital, Florence, n=15) selected based on AC-9 HEp-2 IFA staining (>1:640, clumpy nucleolar pattern) and 102 non-SSc controls [inflammatory bowel disease (IBD) n=20, Sjögren’s syndrome (SjS) n=20, infectious disease (ID) n=7, systemic lupus erythematosus (SLE) n=17, rheumatoid arthritis (RA) n=17, and healthy individuals (HI) n=21]. All samples were tested on the anti-fibrillarin PMAT assay (research use only, Inova Diagnostics, USA). Additionally, the 47 anti-fibrillarin positive samples were also tested on PMAT assays for detecting other autoantibodies in ANA-associated rheumatic diseases (AARD). Anti-fibrillarin antibody data performed by fluorescence enzyme immunoassay (FEIA, Thermo Fisher, Germany) was available for 34 samples. Results: The anti-fibrillarin PMAT assay was positive in 31/32 (96.9%, France) and 12/15 (80.0 %, Italy) of samples preselected based on the AC-9 IIF pattern. Collectively, the PMAT assay showed 91.5% [95% Confidence Interval (CI): 80.1-96.6%] sensitivity with 100.0% (95% CI: 96.4-100.0%) specificity in non-SSc controls. Strong agreement was found between PMAT and FEIA with 100.0% positive qualitative agreement (34/34) and quantitative agreement (Spearman’s rho=0.89, 95% CI:0.77.9-0.95%, p<0.0001). Although most anti-fibrillarin positive samples were mono-specific (69.8%), some expressed additional antibodies (namely Scl-70, centromere, dsDNA, Ro52, Ro60, SS-B, Ribo-P, DFS70, and EJ). Conclusion: The new PMAT assay had high level of agreement to FEIA for the detection of anti-fibrillarin antibodies. Further studies are warranted to investigate the clinical associations and performance of the new method in combination with other critical markers in the SSc panel.
Study on Laser Powder Bed Fusion of Nickel-base Alloy: Scanning Strategy, Properties and Compression Properties
Authors: Qian Bo , Fan Hongri , Li Tengfei , Zhang Jianrui , Xi Jiangtao , Qiu Zhijun 
Published: December 2020

Abstract
Aiming at laser powder bed fusion of GH3536 nickel base alloy, the effects of different scanning strategies on microstructure, porosity and mechanical properties were explored. In the aspect of microstructure and micro hardness of the sample, three scanning strategies had little difference; in the aspect of macro mechanical properties of the sample, the slope subarea scanning was better than the helix and island scanning. On this basis, the slope subarea scanning was selected as the optimal scanning strategy to form the G-surface structure, and the compression performance of G-surface was studied. The results showed that: (1) the compression performance of G-surface structure was smaller than that of solid structure; while G-surface structure had a smooth compression curve, which indicated the good energy absorption characteristics; (2) with the increase of wall thickness, the mechanical performance of G-surface structure was also enhanced, while the energy absorption capacity was constantly reduced; (3) with the same wall thickness, the compression performance of sample in building direction (BD) is higher than that in horizontal direction (HD).
The Curcumin Analog (PAC) Has Anti-Oral Cancer Properties Through Impairing Pro-Survival Signaling Pathways and Activating the Cell Death Processes Apoptosis and Autophagy
Authors: Semlali Abdelhabib , Contant Camille Camille , Al-Otaibi Basem , Al-Jammaz Ibrahim , Chandad Fatiha 
Published: December 2020

Abstract
PAC (3,5-Bis (4-hydroxy-3-methoxybenzylidene)-N-methyl-4-piperidone), a novel bioactive curcumin analog, has been reported to have anticancer properties against various tumors. However, the anti-cancer effects of PAC on oral cavity squamous cell carcinoma (OC-SCC) were not studied yet. Our aim is to investigate the anti-oral cancer properties of PAC in vitro, and determine the molecular mechanisms underlying these effects. Viability assays including MTT and LDH were conducted to measure cell proliferation. Flow cytometry-based cytotoxicity assay was performed to detect autophagic cell death and oxidative stress markers. Western blotting was used for measuring protein expression/activation in apoptotic, autophagic and pro-carcinogenic cellular signaling pathways. We demonstrated that PAC preferentially and, in a dose, -dependent way kills oral cancer cells, but was not toxic to normal human gingival cells. PAC destabilizes cell-cycle distributions, inhibits the expression of oncogenes (cyclin D1) and that of cyclin-dependent kinase inhibitor (p21WAF1) is upregulated, increases the expression of p53 gene, and inhibits epithelial-mesenchymal transition markers in oral cancer cells. The PAC effect involve various signaling pathways including NF-κB, MAPK, Wnt, caspase-3/9 and PARP1. Finally, PAC demonstrated ability to induce autophagy, decrease production of reactive oxygen species (ROS), increase intracellular glutathione (GSH) activity, and reduce mitochondrial membrane potential in oral cancer cells. In conclusion, PAC inhibits the proliferation and increases the apoptosis and autophagy and oxidative stress of oral cancer cells. These effects involve ERK1/2, p38/JNK, NF-κB and Wnt cellular signaling pathways. Overall, our study suggests the potential use of PAC to treat oral cancer.