bluuebunny/crossref_metadata_2025_split huggingface dataset:
How gender-specific are predictors of post-MI HRQoL? A longitudinal study
Authors: Wlodarczyk Dorota , Ziętalewicz Urszula 
Published: January 2020

Abstract
Purpose Extant research shows that health-related quality of life (HRQoL) differs between female and male survivors of myocardial infraction (MI), but the reasons for this are not fully understood. We aimed to examine gender differences in predictors of HRQoL in survivors during the first year after MI.Methods At timepoints 1 and 2 the sample comprised 222 MI survivors (59 women and 163 men; M age 53.84 years, SD = 6.71; range 24-65) referred for in-patient cardiac rehabilitation. This number dropped to 140 participants (42 women and 98 men) at the third timepoint, approx. one year after MI. We examined gender differences in various predictors of physical and mental HRQoL: demographic factors (age; gender identity; marital status; education), disease-related factors (pre- and post-MI), personality and coping with stress.Results Stepwise regressions were performed to investigate how the relationships between the four groups of predictors and HRQoL varied with gender. Initially both physical and mental HRQoL were lower in women than men, but the differences disappeared at timepoint 3. We captured gender differences in factors shaping HRQoL at all timepoints. Substantially fewer factors predicted physical HRQoL in women than in men. The role of predictors also changed over time.Conclusions The psychosocial resources that influence HRQoL differ substantially between women and men; however trait anxiety predicted HRQoL in both genders. Further studies with a different or broader range of predictors are needed.
Diabetes care cascade in Ukraine: An analysis of breakpoints and opportunities for improved diabetes outcomes
Authors: Stuart Robyn , Khan Olga , Abeysuriya Romesh , Kryvchun Tetyana , Lysak Viktor , Bredikhina Alla , Durdykulyieva Nina , Mykhailets Volodymyr , Kaidashova Elvira , Doroshenko Olena , Shubber Zara , Wilson David , Zhao Feng , Fraser-Hurt Nicole 
Published: January 2020

AbstractBackground Diabetes is one of the leading causes of poor health and high care costs in Ukraine. An estimated 3 million adults live with the condition, placing diabetes in the top ten causes of years lived with disability. To prevent diabetes complications and alleviate the financial burden of diabetes care on patients, the Ukrainian government reimburses diabetes medication and provides glucose monitoring, but there are significant gaps in the care continuum. We estimate the costs of providing diabetes care and the most cost-effective ways to address these gaps in the Poltava region of Ukraine.Methods We gathered data on the unit costs of diabetes interventions in Poltava region in 2017 and estimated expenditure on diabetes care. We then applied the Cascade Analysis Tool, a model for analyzing and optimizing health service implementation, to estimate the optimal combination of facility-based and outreach screening and investigate how additional funding could best be allocated to improve glucose control outcomes.Results Of the ~40000 adults in diabetes care, only ~25% achieved sustained glucose control. Monitoring costs were higher for those who did not: by 10% for patients receiving non-pharmacological treatment, by 61% for insulin patients, and twice as high for patients prescribed oral treatment. Investments in initiatives to improve treatment adherence (e.g. medication copayment schemes, enhanced adherence counseling) would address barriers along the care continuum and we estimate such expenditures may be recouped by reductions in patient monitoring costs. Improvements in case detection are also needed, with only around two-thirds of estimated cases having been diagnosed. Outreach screening campaigns could play a significant role: depending on how well-targeted and scalable such campaigns are, we estimate that 10–46% of all screening could be conducted via outreach, at a cost per positive patient identified of US$7.12–9.63.Conclusions Investments to improve case detection and treatment adherence are the most efficient interventions for improved diabetes control in Poltava region. Quantitative tools such as the Cascade Analysis Tool provide essential decision support for targeting investment into services which close the gaps in implementation.
Dengue risk map using GIS based on socio-environmental and climatic variables in residential area
Authors: Adnan Ruhil Amal , Ramli Mohammad Firuz , Othman Hidayathul Fathi , Asha’ri Zulfa Hanan , Ismail Sharifah Norkhadijah Syed , Zaudi Muhammad Amar , Umar Da’u Abba 
Published: January 2020

Abstract

Background Dengue, a major international health problem, is transmitted by aedes mosquitoes. Due to the lack of a vaccine, vector control by tackling the contribution factors may reduce dengue incidence. By understanding the factors contributed to the vector densities such as sociological, environmental and climatic factors, dengue prevention and control will succeed.Objective This study is aimed at determining the major sociological, environmental and climatic factors contributing to dengue cases and to produce the risk map based on the contributing factorsMethods Questionnaire survey of 379 respondent with dengue history were utilized. The climatic data were obtained from Malaysia Meteorological Department. Geographical Information System (GIS) technology has been used to integrate the socio-environmental and climatic factors with dengue casesResult The chi-square results revealed that there is a significant association between respondent’s dengue history and houses that are shaded with vegetation (p= 0.012) and the present of playground areas near the residential (p = 0.011) whilst Pearson’s Correlation showed that dengue cases in Kuala Lumpur were significantly correlated with temperature, relative humidity and rainfall (p < 0.05)Conclusion The study identified socio-environmental factors that play an important role to develop the risk maps. The risk map can be useful baseline for decision maker to strategize and create preventive measure for controlling aedes mosquitoes.
Pharmacodynamics of siRNARANKL and Oestrogen Loaded MSNs-CADY on Human Periodontal Ligament Stem Cells with Porphyromonas gingivalis infection
Authors: Song Liang , Shi Xiaojun , Hu Fengling , Chen Huijuan , Xu Bin , Li Yinghua , Li Yan 
Published: January 2020

Abstract
Background: Periodontitis irreversibly invades and destroys periodontal supporting tissues, loses the ability of periodontal regeneration and restoration, and eventually leads to tooth loosening and loss. periodontal ligament stem cells (PDLSCs) hold great promises for periodontal tissue regeneration which was the potential target of periodontitis treatment, siRNARANKL and oestrogen can help PDLSCs maintain normal function, however, it was very difficult for siRNARANKL and oestrogen to get into PDLSCs. Here, Cell penetrating peptide CADY was modified on the surface of siRNARANKL and oestrogen loaded mesoporous silica nanoparticles (MSNs) to carry them into Porphyromonas gingivalis infected PDLSCs, Then further affect the proliferation of PDLSCs. Methods: 120-150 nm Mesoporous silica nanoparticles (MSNs) was prepared, and the biocompatibility, loading capacity and drug release properity were tested; MSNs was modified by penetrating peptide CADY and the prepared MSNs/CADY was loaded with siRNARANKL and oestrogen; In vitro drug release of siRNARANKL/MSNs-CADY and oestrogen/MSNs-CADY was tested by using semi-permeable dialysis bag diffusion; Cellular uptake and internalization of FITC-Labeled MSNs and FITC-Labeled MSNs-CADY was observed by use of Laser confocal microscopy; Finally, the effect of siRNARANKL and oestrogen loaded MSNs-CADY on cell proliferation of Porphyromonas gingivalis infected human periodontal ligament stem cells was tested by MTT assay. Results: according to the results, MSNs-CADY with a concentration of 6.25-200 ug/mL have no toxic to PDLSCs; 24.6 mg oestrogen and 0.5 mM siRNARANKL can be loaded into 1mg of MSNs-CADY; and drug loaded MSNs-CADY nanodrug carriers can release siRNARANKL and oestrogen stably for at least 48 h; After modification with cell penetrating peptide CADY, more MSNs-CADY can be taken by PDLSCs. siRNARANKL/oestrogen/MSNs-CADY can increase the proliferation of PDLSCs significantly. Conclusion: siRNARANKL/oestrogen/MSNs-CADY constructed can significantly improve the cell proliferation of P-gingivalis infected PDLSCs, this nano drug carrier has the potential to be used in PDLSCs -based periodontitis treatment, this work provided a useful theoretical basis and therapeutic ideas for the treatment of periodontitis.
Improving maternal and child nutrition in China: An analysis of nutrition policies and programs initiated during the 2000-2015 Millennium Development Goals era, and implications for achieving the Sustainable Development Goals
Authors: Huang Xin , Yang Bo , Liu Qin , Zhang Ruilin , Tang Shenglan , Story Mary 
Published: January 2020

Abstract
Background: Although good progress was made in maternal and child nutrition during the Millennium Development Goals (MDGs) era, malnutrition remains one of the major threats on global health. Therefore, the United Nation set several nutrition-related goals in the Sustainable Development Goals (SDGs). There is much to be learned from individual countries in terms of efforts and actions taken to reduce malnutrition in order to achieve the nutrition-related SDGs. China as a developing country launched a number of nutrition improvement policies and programs, that resulted in dramatic progress in improving maternal and child nutrition during the MDGs era. This study explored the impact, experiences and lessons learned from nutrition policies and programs initiated in China during the MDGs era, and implications to achieve the SDGs for China and other developing countries. Method: The CNKI database and official websites of Chinese Government were searched for reviews on nutrition-related policies and intervention programs. A qualitative study was conducted among key informants from the Chinese government, Non-governmental Organizations (NGOs) and Universities for two major national nutrition intervention programs. Results: The literature review documented that during the MDGs six nutrition policies and eight trans-province and nationwide nutrition intervention programs collectively made good progress in improving maternal and child nutrition in China. Nutrition Policies tended to be targeted at infants and children, with less attention on reproductive and maternal nutrition. Nutrition intervention programs focused primarily on undernutrition and achieved positive results, while for breastfeeding improvement and prevention and control on overweight and obesity were limited. Results from the qualitative study indicated that effective nutrition program implementation was facilitated through cooperation of multiple sectors and by government and NGOs partnerships, however, still face challenges of insufficient local working funds, monitoring and inadequate management. Conclusion: Nutrition policies and intervention programs promulgated in China during the MDGs era made major contributions to the rapid decline of undernutrition, and are in line to achieve the SDGs related to child wasting, stunting, low birth weight and anemia in reproductive-age women. However, policies and program implementation are needed to improve exclusive breastfeeding rates and reduce obesity to achieve the SDGs.
Reconstruction of ancestral diploid karyotype and evolutionary trajectories leading to the formation of Camelina sativa chromosomes
Authors: Zhang Zhikang , Meng Fanbo , Sun Pengchuan , Yuan Jiaqing , Ge Ke , Liu Chao , Wang Weijie , Wang Xiyin 
Published: January 2020

Abstract
Background: Belonging to lineage Ⅰ of Brassicaceae, Camelina sativa is formed by two hybridizations of three species (three sub-genomes). The three sub-genomes were diverged from a common ancestor, likely derived from lineage Ⅰ (Ancestral Crucifer karyotype, ACK). The karyotype evolutionary trajectories of the C. sativa chromosomes are currently unknown. Here, we managed to adopt a telomere-centric theory proposed previously to explain the karyotype evolution in C. sativa. Results: By characterizing the homology between A. lyrate and C. sativa chromosomes, we inferred ancestral diploid karyotype of C. sativa (ADK), including 7 ancestral chromosomes, and reconstructed the karyotype evolutionary trajectories leading to the formation of C. sativa genome. The process involved 2 chromosome fusions. We found that sub-genomes Cs-G1 and Cs-G2 may share a closer common ancestor than Cs-G3. Together with other lines of evidence from Arabidopsis, we propose that the Brassicaceae plants, even the eudicots, follow a chromosome fusion mechanism favoring end-end joining of different chromosomes, rather than a mechanism favoring the formation circular chromosomes and nested chromosome fusion preferred by the monocots. Conclusions: The present work will contribute to understanding the structural and functional innovation of C. sativa chromosomes, providing insight into Brassicaceae karyotype evolution.
Semiconductor Photocatalysts for Solar-to-Hydrogen Energy Conversion: Recent Advances of CdS
Authors: Wei Yuxue , Qin Honglin , Deng Jinxin , Cheng Xiaomeng , Cai Mengdie , Cheng Qin , Sun Song 
Published: January 2020

Background:
Photocatalytic hydrogen evolution from water splitting using photocatalyst
semiconductors is one of the most promising solutions to satisfy the increasing demands of a rapidly
developing society. CdS has emerged as a representative semiconductor photocatalyst due to its suitable
band gap and band position. However, the poor stability and rapid charge recombination of CdS
restrict its application for hydrogen production. The strategy of using a cocatalyst is typically recognized
as an effective approach for improving the activity, stability, and selectivity of photocatalysts.

Introduction:
Solar-driven photocatalytic hydrogen production from water splitting is one of the
most promising solutions to satisfy the increasing demands of a rapidly developing society. CdS has
emerged as a representative semiconductor photocatalyst due to its suitable band gap and band position.
However, the poor stability and rapid charge recombination of CdS restrict its application for
hydrogen production. The strategy of using a cocatalyst is typically recognized as an effective approach
for improving the activity, stability, and selectivity of photocatalysts. In this review, recent
developments in CdS cocatalysts for hydrogen production from water splitting under visible-light irradiation
are summarized. In particular, the factors affecting the photocatalytic performance and new
cocatalyst design, as well as the general classification of cocatalysts, are discussed, which includes a
single cocatalyst containing noble-metal cocatalysts, non-noble metals, metal-complex cocatalysts,
metal-free cocatalysts, and multi-cocatalysts. Finally, future opportunities and challenges with respect
to the optimization and theoretical design of cocatalysts toward the CdS photocatalytic hydrogen
evolution are described.

Methods:
This review summarizes the recent developments in CdS cocatalysts for hydrogen production
from water splitting under visible-light irradiation.

Results:
Recent developments in CdS cocatalysts for hydrogen production from water splitting under
visible-light irradiation are summarized. The factors affecting the photocatalytic performance and
new cocatalyst design, as well as the general classification of cocatalysts, are discussed, which includes
a single cocatalyst containing noble-metal cocatalysts, non-noble metals, metal-complex cocatalysts,
metal-free cocatalysts, and multi-cocatalysts. Finally, future opportunities and challenges
with respect to the optimization and theoretical design of cocatalysts toward the CdS photocatalytic
hydrogen evolution are described.

Conclusion:
The state-of-the-art CdS for producing hydrogen from photocatalytic water splitting under
visible light is discussed. The future opportunities and challenges with respect to the optimization
and theoretical design of cocatalysts toward the CdS photocatalytic hydrogen evolution are also described.
A Sequence-segment Neighbor Encoding Schema for Protein Hotspot Residue Prediction
Authors: Chen Peng , Shen Tong , Zhang Youzhi , Wang Bing 
Published: January 2020

Background:
Hotspots are those residues that contribute major free energy of binding
in protein-protein interactions. Protein functions are frequently dependent on hotspot residues. At
present, hotspot residues are always identified by Alanine scanning mutagenesis technology,
which is costly, time-consuming and laborious.

Objective:
Therefore, more accurate and efficient methods have to be developed to identify protein
hotspot residues.

Methods:
This paper proposed a novel encoding schema of sequence-segment neighbors and
constructed a random forest-based model to identify hotspots in protein interaction interfaces.
Firstly, 10 amino acid physicochemical properties, 16 features related to the PI and DI, and 25
features related to ASA were extracted. Different from the previous residue encoding schemas,
such as auto correlation descriptor or triplet combination information, this paper employed the
influence of amino acids neighbors to hotspot residues and amino acids with a certain distance in
sequence to the hotspot.

Results:
Moreover, the proposed model was compared with other hotspot prediction methods,
including APIS, Robetta, FOLDEF, KFC, MINERVA models, etc.

Conclusion:
The experimental results showed that the proposed model can improve the prediction
ability of protein hotspot residues on the same test set.
The In Vitro Study of Anti-leishmanial Effect of Naja naja oxiana Snake Venom on Leishmania major
Authors: Fallahi Nastaran , Shahbazzadeh Delavar , Maleki Fatemeh , Aghdasi Marjaneh , Tabatabaie Fatemeh , Khanaliha Khadijeh 
Published: January 2020

Background:
Although a majority of patients with cutaneous leishmaniasis (CL) are
healed with Glucantime chemotherapy, the increased drug resistance rate following its application is
a concern. In this study, Naja naja oxiana crude venom of cobra snakes was used for the first time
as an assembled combination of bioactive pharmaceutical components on Leishmania major (L.
major) standard strain.

Objective:
To evaluate the efficacy of the Naja naja oxiana crude venom of Iranian cobra snakes on
Leishmania major standard strain in vitro.

Methods:
Five concentrations (1.25, 2.5, 5, 10 and 20 μg/mL) of venom were added to Leishmania
major cultures at 24, 48 and 72 h. The viability of the parasites and venom toxicity were assessed by
MTT test. The apoptosis was determined by flow cytometry, while IC50 was determined by counting
parasites compared to that of glucantime. Each test was conducted in triplicate.

Results:
After the exposure of the venom for 72 h, IC50 value was 0.36 μg/mL and 14.12 μg/mL for
promastigotes and amastigotes, respectively. MTT valuation clarified 1.01% promastigotes viability.
Furthermore, the results indicated that the venom of Naja naja oxiana induced early and late
apoptosis in parasites.

Conclusions:
The venom of Naja naja oxiana revealed remarkable anti-leishmanial effects as a
novel anti-parasitic alternative. Thus, the bioactive and effective fractions of this venom may be
considered as anti-leishmanial candidates in future studies.
ВИЗНАЧЕННЯ ЕФЕКТИВНОСТІ ВПРОВАДЖЕННЯ ПРОГРАМИ ФІЗИЧНОЇ ТЕРАПІЇ ДЛЯ ХВОРИХ ОЖИРІННЯМ ІІІ СТУПЕНЯ ЗА ДИНАМІКОЮ МЕТАБОЛІЧНИХ ПАРАМЕТРІВ
Authors: Аравіцька М. Г. 
Published: January 2020

Резюме. Цілі: визначення динаміки показників метаболізму у пацієнтів із ожирінням під впливом програми фізичної терапії.
Методи. Обстежено 74 особи з ожирінням ІІІ ступеня. За величиною реабілітаційного комплаєнсу вони були поділені на групу порівняння (низький рівень) та основну групу (високий рівень). Групу контролю склали 63 особи з нормальною масою тіла. Оцінювали антропометричні показники (маса, індекс маси тіла, співвідношення обхватів талії та стегон); параметри вуглеводневого (вміст глюкози в крові натще та після глюкозного навантаження) та ліпідного (концентрація холестерину, тригліцеридів, ліпопротеїдів високої щільності, лептину) обмінів; розраховували індекс вісцерального ожиріння. Запропонована програма фізичної терапії включала підтримку реабілітаційного комплаєнсу, збільшення фізичної активності, зміну стилю харчування, рефлексотерапію, масаж, психокорекцію.
Результати. Було досягнуто статистично значущого покращення щодо вихідних показників досліджуваних параметрів осіб основної групи. Втрата маси тіла становила більше 20%, індекс маси тіла досяг параметрів ожиріння І ступеня, зменшився ступінь абдомінального ожиріння. Відбулися позитивні зміни в концентраціях глюкози натще, відновилась чутливість тканин до глюкози; знизились параметри атерогенності; покращився індекс вісцерального ожиріння та рівень лептину. У пацієнтів із низьким рівнем комплаєнсу позитивних змін досліджуваних показників не виявлено.
Висновки. Внаслідок впровадження програми визначено статистично значуще у порівнянні із вихідним результатом покращення досліджуваних показників обміну ліпідів та глюкози на фоні покращення антропометричних параметрів. Проте рівня параметрів осіб із нормальною масою досягнуто не було, що свідчить про потребу тривалішої, ніж 1 рік, програми реабілітації осіб із ожирінням ІІІ ступеня.
ЗМІНИ АМПЛІТУДНО-ЧАСТОТНОГО СПЕКТРУ КОЛИВАНЬ КРОВОТОКУ ПІД ЧАС ОПЕРАТИВНИХ ВТРУЧАНЬ З ПРИВОДУ СПАЙКОВОЇ КИШКОВОЇ НЕПРОХІДНОСТІ
Authors: Дейкало І. М. , Буката В. В. , Чорномидз А. В. 
Published: January 2020

Резюме. Мета роботи: дослідити зміни амплітудно-частотного спектру коливань кровотоку протягом інтраопераційного періоду у пацієнтів із спайковою кишковою непрохідністю.
Матеріали та методи дослідження. Нами обстежено 57 хворих на гостру спайкову кишкову непрохідність. Серед них 31 хворий прооперований відкритим способом та 26 хворих, яким проведено малоінвазивні втручання. Усім хворим проведено лазерну допплерівську флоуметрію. Обстеження проводили у безперервному режимі протягом усього оперативного втручання. Аналіз амплітудно-частотного спектру коливань кровотоку проводили за допомогою вейвлет-аналізу.
Результати дослідження. Встановлено, що протягом оперативного втручання стан мікроциркуляції зазнає змін залежно від періоду оперативного втручання. В усіх хворих на початку операції відмічається зростання усіх амплітуд коливань кровотоку. В подальшому при лапаротомних оперативних втручаннях виявлені зміни, що вказують на зниження кровопостачання тканин, підвищення резистентності артеріол та порушення відтоку крові з капілярного русла. При лапароскопічних втручаннях виявлено ознаки зниження функціональної активності ендотелію, зростання тиску у капілярах, виникнення застою в капілярному руслі.
Висновки. В обстежених хворих інтраопераційно виявлено значні зміни на рівні системи мікроциркуляції, що можуть призвести до гіпоксії органів та систем, розвитку дисфункції паренхіматозних органів, зростання ризику розвитку тромбоемболічних ускладнень та ін. Отже, як відкриті, так і лапароскопічні оперативні втручання мають, відносно досліджуваних показників, свої переваги та недоліки, на які необхідно звертати увагу під час хірургічного лікування спайкової кишкової непрохідності.