bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eficacia Diagnóstica de la Angiografía por Tomografía en Cardiopatías Congénitas.
Authors: Espinoza Balseca Lilibeth Kayra , Guadamo Colina Jesus Gabriel , Páez Valverde César Augusto , Cunache Baquerizo Rafael Arnaldo , Gutierrez Gomez Ricardo 
Published: December 2024

Introducción: Las cardiopatías congénitas (CC) son malformaciones estructurales diversas que surgen durante el desarrollo embrionario, desde defectos menores hasta anomalías que amenazan la vida. El diagnóstico temprano es crucial para el manejo efectivo y mejora de resultados en los pacientes. Objetivo: Esta revisión evalúa la eficacia diagnóstica de la angiografía por tomografía computarizada (ATC) en cardiopatías congénitas. Metodología: Se realizó una revisión de la literatura en bases de datos como PubMed y Web of Science, enfocándose en estudios desde 2014 en adelante. Se incluyeron artículos que evaluaron específicamente la eficacia de la ATC en el diagnóstico de CC. Resultados: La ATC ofrece imágenes tridimensionales de alta resolución cruciales para el diagnóstico de defectos cardiacos congénitos. Destaca en el detalle de vasos sanguíneos pequeños y en la planificación preoperatoria gracias a su rápida adquisición de imágenes. No obstante, la exposición a la radiación y el uso de agentes de contraste representan riesgos, especialmente en poblaciones pediátricas. Conclusión: La ATC es una herramienta diagnóstica altamente eficaz en el manejo de CC debido a su superior resolución espacial. Es esencial seguir investigando para reducir la exposición a radiación y capacitar adecuadamente al personal médico. Se requieren estudios colaborativos para confirmar su aplicación expandida.
Perancangan Pembelajaran Media Animasi (Studi Kasus SD Negeri 22 Rantau Utara) Dengan Menggunakan Adobe Flash
Authors: Hutagalung Devi Lestari , Masrizal Masrizal , Irmayanti Irmayanti 
Published: December 2024

Dalam era digital seperti sekarang adalah zaman yang maju. Dalam kemajuan tersebut didukung oleh teknologi yang berkembang pesat. Komputer dapat digunakan sebagai sarana pembelajaran yang menarik dan interaktif, sehingga dapat meningkatkan minat dan antusias peserta didik. Media pembelajaran berbasis komputer dapat menyajikan materi pembelajaran secara visual dan audio yang lebih menarik dan mudah dipahami. Selain itu, media pembelajaran berbasis komputer juga dapat memberikan umpan balik secara langsung kepada peserta didik, sehingga dapat membantu siswa untuk memahami materi pembelajaran dengan lebih baik , tempat penelitian SDN 22 Rantau Utara merupakan salah satu sekolah Dasar Negeri di daerah Pulo Padang yang beralamat di Pasir Tinggi, kecamatan rantau utara kabupaten labuhanbatu sumatra utara. SDN 22 Rantau Utara. Penelitian ini menggunakan Adobe Flash sebagai aplikasi perancangan animasi pengenalan huruf dan angka.
Vedolizumab serum trough concentrations with and without thiopurines in ulcerative colitis: The prospective VIEWS pharmacokinetics study
Authors: Chaemsupaphan Thanaboon , Pudipeddi Aviv , Lin Hui-Yu , Paramsothy Sudarshan , Kariyawasam Viraj C , Kermeen Melissa , Leong Rupert W 
Published: December 2024

BACKGROUND
Ulcerative colitis (UC) is a chronic inflammatory condition requiring continuous treatment and monitoring. There is limited pharmacokinetic data on vedolizumab during maintenance therapy and the effect of thiopurines on vedolizumab trough concentrations is unknown.
AIM
To investigate the exposure-response relationship of vedolizumab and the impact of thiopurine withdrawal in UC patients who have achieved sustained clinical and endoscopic remission during maintenance therapy.
METHODS
This is a post-hoc analysis of prospective randomized clinical trial (VIEWS) involving UC patients across 8 centers in Australia from 2018 to 2022. Patients in clinical and endoscopic remission were randomized to continue or withdraw thiopurine while receiving vedolizumab. We evaluated vedolizumab serum trough concentrations, presence of anti-vedolizumab antibodies, and clinical outcomes over 48 weeks to assess exposure-response association and impact of thiopurine withdrawal.
RESULTS
There were 62 UC participants with mean age of 43.4 years and 42% were females. All participants received vedolizumab as maintenance therapy with 67.7% withdrew thiopurine. Vedolizumab serum trough concentrations remained stable over 48 weeks regardless of thiopurine use, with no anti-vedolizumab antibodies detected. Patients with clinical remission had higher trough concentrations at week 48. In quartile analysis, a threshold of > 11.3 μg/mL was associated with sustained clinical remission, showing a sensitivity of 82.4%, specificity of 60.0%, and an area of receiver operating characteristic of 0.71 (95%CI: 0.49-0.93). Patients discontinuing thiopurine required higher vedolizumab concentrations for achieving remission.
CONCLUSION
A positive exposure-response relationship between vedolizumab trough concentrations and UC outcomes suggests that monitoring drug levels may be beneficial. While thiopurine did not influence vedolizumab levels, its withdrawal may necessitate higher vedolizumab trough concentrations to maintain remission.
Re-presentación de la Guerra civil y del franquismo en Montserrat, Jeunesse bafouée y Paris Liberté de Julio Ribéra
Authors: THOUVEREZ LUDIVINE , GONZÁLEZ MEDIANO David 
Published: December 2024

Este artículo analiza el relato memorial histórico que ofrece el autor catalán Julio Ribéra (1927-2018) en su trilogía de la memoria, publicada entre 2004 y 2006 en Francia. Exiliado en París en la década de los 50, Ribéra alcanzó fama por sus obras de ciencia ficción o de corte fantástico. En los años 2000, coincidiendo con el inicio del debate sobre la memoria histórica en España, realiza una obra autobiográfica compuesta de tres álbumes: Montserrat. Souvenirs de la guerre civile (2004), Jeunesse bafouée. Une dictature au fil des jours (2005) y Paris Liberté. Le parfum de l'espoir (2006). La singularidad de esta obra nos lleva a plantear las siguientes cuestiones: ¿en qué medida supone la trilogía una ruptura respecto a las obras de ciencia ficción que Ribéra realizó antes? ¿Qué relación mantiene con la realidad histórica? ¿Cómo se documenta y se plasma la memoria individual y colectiva en ella? Basándonos en los aportes teóricos de Thierry Groensteen sobre arte secuencial, y de Isabelle Delorme y Bart Beaty sobre el relato autobiográfico o memorial histórico en el cómic, presentaremos la génesis de la obra, su particular visión partidista de la guerra civil, el recurso en ella del realismo y de la subjetividad, así como su aportación a la mejor comprensión de la obra de Ribéra.
Moving Mountains and Swallowing Seas: Śaiva Gurus as Ecological Agents in Early South and Southeast Asia
Authors: Cecil Elizabeth A. 
Published: December 2024

The worship of Śiva in early South and Southeast Asia offered devotees a fully realized “religious ecology,” i.e., a system of mutually beneficial relationships between human communities, natural systems, and the nonhuman or more-than-human worlds in which they operated. Within this religious worldview, the Śaiva guru functioned as a critical terrestrial intermediary. In canonical early Śaiva texts, the guru was celebrated as an ecological agent capable of alleviating suffering and nurturing community. In material culture, the guru’s iconographic attributes (e.g., waterpot, trident, and lotus) signaled his ability to offer devotees emotional, social, and environmental benefits.
Using the figure of the Brahmanical sage and Śaiva guru Agastya as an entrée, this study initiates a comparative analysis of the cultural connections between gurus, Śiva worship, and the power of the natural world as expressed through iconographic programs and architectural spaces from northern India, Vietnam, and Java. Since Agastya is both a personification of Brahmanical cultural authority and a transregional emblem of the Śaiva tradition, he provides a fertile ground from which to explore the role of the guru in early South and Southeast Asia. Agastya’s mythic biography also features two significant environmental interventions: subduing the Vindhya Mountain when it threatened to block out the sun, and drinking the ocean’s waters to reveal hidden demons threatening a divine order. His ecological agency, expressed in narratives as the power to neutralize potential threats in the natural world and manifest beneficence, is materialized in images that express the socially supportive values of prosperity and fertility.
Rock, Paper, Scissors: Durable Ephemera and Networks of Stone in Quanzhou’s Zhenguo Pagoda
Authors: Purtle Jennifer 
Published: December 2024

Building a pagoda mobilizes durable materials into architectonic form. But a pagoda may also incorporate likenesses of images and objects wrought in ephemeral materials, thus becoming a nexus of textual, pictorial, and formal transfer and intermedial preservation. This essay examines how, in the Zhenguo pagoda 鎮國塔 (lit. “Defender of the State Pagoda”) at the Kaiyuan temple in Quanzhou, Fujian, rock—covered with the imagery of paper (and other fugitive media) by means of scissors (or, more precisely, the carver’s knife)—preserved traces of evanescent forms. Specifically, it: articulates the relationship of paper-based editions of the Buddhist canon to the pagoda’s stone-carved narrative program; asserts the influence of logographic schema of printed-paper primers and locally known, silk-based court painting styles to the pagoda’s imagery; and contends that carved images of small, free-standing bronze (and stone) pagodas link the Zhenguo pagoda to overlapping local (Quanzhou), regional (Min-Yue/Fujian), imperial (Song-dynasty), and maritime (Indian Ocean) object networks. To test the hypothesis that the Zhenguo pagoda serves as a repository of, and lexicon for, now lost forms, this essay concludes by using the imagery of the Zhenguo pagoda to recover the iconography of a type of Quanzhou-specific Buddhist monument, the Stone Shoot (Shisun 石筍).
Les « grottes-sanctuaires » gallo-romaines du Morbihan, éléments d’une géographie du sacré chez les Vénètes
Authors: Galliou Patrick 
Published: December 2024

Dans le Morbihan, trois cavités naturelles, grottes et abris sous roche, explorées de façon sommaire à la fin du xixe siècle et au début du siècle suivant, ont livré un abondant mobilier archéologique d'époque romaine, essentiellement constitué de statuettes de terre blanche (Vénus, déesses-mères, etc.). Il s'agit, selon toute vraisemblance, d'endroits où était pratiquée une propitiation des divinités souterraines, visant à obtenir de celles-ci des récoltes abondantes. On ne connaît pas, à ce jour, d'autres exemples de telles utilisations de lieux souterrains à l'époque romaine dans la péninsule armoricaine.
La lecture jeunesse en breton, une clé de compréhension de la situation sociolinguistique de Bretagne, entre enjeux, représentations et pratiques
Authors: Rouxel Eve 
Published: December 2024

Cet article propose d'envisager les bouleversements sociolinguistiques de ce dernier siècle sous l'éclairage de la lecture en breton, et plus largement de la perception de la langue écrite. Alors que le nombre de locuteurs du breton a chuté de façon vertigineuse et que les 60 ans et plus représentent aujourd'hui près de 80 % des locuteurs, le nombre de publications en langue bretonne a connu lui une augmentation sans précédent, et en particulier dans le domaine de la littérature de jeunesse qui représente plus de la moitié des publications ces dernières années. L'étude des enjeux autour de la langue bretonne écrite, des pratiques effectives de lecture des jeunes et des attentes de leurs parents dans ce domaine vient questionner l'évidence d'une convergence des attentes autour du bilinguisme par le biais de l'école, et souligne les logiques différentes en œuvre chez des acteurs que l'on aurait a priori placé dans la même structure de distribution, mais dont il apparaît qu'ils ne « jouent » pas nécessairement selon les mêmes règles.
Comparing the Efficacy of Dexmedetomidine Administered as an Intravenous Infusion and Intravenous Bolus on Hemodynamic Stability of Patients Undergoing Ear, Nose, and Throat Surgeries
Authors: Siddappa Prajwal , Kamath Shaila Surendra 
Published: December 2024

Abstract

Background and Aims:
Dexmedetomidine has been administered as an intravenous infusion for maintenance dose following a loading dose, however, there is no study conducted so far that has compared the effectiveness of dexmedetomidine administered as bolus intravenously. The study aimed to compare the hemodynamic stability between intravenous infusion and intravenous bolus injection dexmedetomidine.

Methodology:
A comparative observational study was conducted among 60 participants aged 20–60 years with American Society of Anesthesiologists physical status I/II, scheduled to undergo elective ear, nose, and throat surgeries. Participants were divided into Group A (received a loading dose of 0.5 μg/kg followed by 0.3 μg/kg/h intravenous infusion of dexmedetomidine) and Group B (an intravenous bolus of dexmedetomidine 0.5 μg/kg) 15 min before the induction of anesthesia. Hemodynamic variables, anesthetic requirement, blood loss, volume of intravenous fluid, recovery time, pain scores, rescue analgesia required, and any adverse events were recorded.

Results:
Heart rate, blood pressure (BP), and mean arterial pressure were found to be significantly higher among participants receiving dexmedetomidine in the bolus group (P = 0.001). Diastolic BP was higher 90 min after intubation. Mean propofol administered, total blood loss, and total intravenous fluid volume were significantly higher in the bolus group (P = 0.001). Pain scores were higher in the bolus group after 2 h and infusion group after 12 h. Participants in the infusion group took more time to recover from anesthesia.

Conclusion:
Almost all outcome variables were significantly higher among the bolus group. The recovery time was nonetheless reduced. There were no adverse events reported in both groups.
Assessing the effectiveness of brief interventional group therapy on severity of illness, readiness for change, self-efficacy and motivation levels in patients with alcohol use disorder: A pre-post study
Authors: Bagde Romesh , Kadiani Adnan , Kedare Janhavi , Shailly Smriti 
Published: December 2024

Background:
There has been an increase in the estimated burden of alcohol use disorders (AUD) in countries like India. Treatment of AUD needs to be multi model and can be pharmacological and Psychological is their approach. Brief interventions are an effective approach to reducing drinking.

Aim:
To assess if brief group intervention has any change in the motivation stage, readiness to change scores, self efficacy levels of an individual.

Materials & Method:
Alcohol use disorder patients were included and pre intervention scales—Severity of Alcohol Dependence Questionnaire {SADQ}, Stage of change readiness and treatment eagerness, General Self efficacy scale, University of Rhodes Island change assessment scale were applied. Three Group sessions were taken on a weekly basis and scales were re applied at the end of 12 weeks.

Results:
A total of 83.33% of the participants were in early remission, the SADQ scores decreased in all participants, and 60% were in the Action phase of Motivation. Approximately 80% had a high score on the taking steps component of readiness to change scale and there was a statistically significant increase in the mean self efficacy score post intervention.

Conclusion:
Brief group intervention involving psychoeducation and motivational enhancement techniques is a low cost, simple, and time saving behavioral intervention that not only increases rates of early remission but also leads to change in motivation and self efficacy levels.
Persistent pulmonary impairment after 2 years of COVID-19 infection: An observational study
Authors: Suri Tejas Menon , Srivastava Garima , Kumar Sunil , Surendranath A , Shaji Syam , Mittal Saurabh , Tiwari Pawan , Hadda Vijay , Madan Karan , Chauhan Abhishek , Mohan Anant 
Published: December 2024

ABSTRACT

Background:
Persistent dyspnoea and pulmonary function impairment are common after coronavirus disease 2019 (COVID-19). However, long-term outcomes beyond 2 years of infection are unknown.

Methods:
In this single-center study, we observed the trend of self-reported dyspnoea and pulmonary functions among subjects attending a post-COVID clinic in India after 2 years of COVID-19 illness. Using logistic regression, we explored the clinico-demographic factors associated with persistent dyspnoea and impaired lung functions beyond 2 years.

Results:
Among 231 included subjects (68.8% male) with a mean [standard deviation (SD)] age of 44.8 (13.2) years, 119 (51.5%) had recovered from moderate-to-severe COVID-19. The median [inter-quartile range (IQR)] time intervals from COVID-19 diagnosis (T0) to clinical enrolment (T1) and final follow-up (T2) were 3.3 (1.9–5.5) months and 29.5 (27.2–32.2) months, respectively. Between T1 and T2, the prevalence of self-reported dyspnoea remained stable in the whole cohort (39.4% vs. 36.4%, P = 0.26) but declined in the sub-group with moderate-to-severe COVID-19 (63% vs. 54.6%, P = 0.03). Persistent dyspnoea at T2 was associated with female sex (P = 0.007), moderate-to-severe COVID-19 (P < 0.001), and infection during the delta wave (P < 0.001). At T2, impairment in forced vital capacity (FVC) was seen in 48.1% subjects. Persistently impaired FVC was associated with older age (P value = 0.047), female sex (P value <0.001), and infection during the delta wave (P value = 0.02).

Conclusion:
Persistent self-reported dyspnoea and impaired pulmonary functions were common in COVID-19 survivors beyond 2 years of infection. Female sex and infection during the delta wave were associated with long-term impairments.
Schwannomas of C1: A Novel Classification and Description of Growth Patterns Based on a Personal Series and Review of Literature
Authors: Sridhar Krish 
Published: December 2024

Background:
Schwannomas of C1 are rare tumors. Because of the wide variation in their anatomy, and presentation and their rarity, there is no proper understanding of their pathological anatomy nor their optimal management.

Methods:
A retrospective study of the C1 schwannomas operated by the author between 2000 and 2020 and a PubMed-based search of English literature were done to analyze data on the location and extent of the lesions, surgical approaches used, and operative outcomes. Using this data, a classification system was created indicating the location and extent of these lesions, depending on whether they were extradural (E) or intradural (I); with further subdivisions based on their relation to the vertebral artery, and cervicomedullary junction (CMJ).

Results:
Six patients with C1 schwannoma were operated by the author in the said period. Literature search yielded 44 cases in 16 publications. The details of location and extent of tumor were available in 22 patients including six of this article. Most of the tumors were intradural (13/22), with six in intradural and extradural compartments. Specific growth patterns were identified and a theory for this is proposed. Different surgical approaches were used; the far lateral and the posterolateral in 9 patients each, and the posterior midline in 7 of 25 patients. Using the available data, preferred surgical approaches are also presented.

Conclusions:
C1 schwannomas are a rare and complex group of tumors. The classification presented will help in understanding the growth pattern and pathological anatomy and choose the preferred surgical approach.
Assessment of White Matter Alterations in Patients of Migraine Using Diffusion Tensor Imaging
Authors: Nanda Civilee , Sachdev Namrita 
Published: December 2024

Background:
Vascular hypotheses was previously considered to play a major role in pathophysiology of migraine. Recently, neurological mechanisms have been proposed with implication of the trigemino-vascular pathway. Deciphering the pathophysiology of this disorder is extremely important for diagnosis, assessment of progression and to explore targeted treatment options.

Objectives:
To assess white matter alterations in patients of migraine by using Diffusion Tensor Imaging.

Materials and Methods:
We performed Diffusion Tensor Imaging in migraine patients to assess changes in microstructural integrity of white matter tracts involved in pain processing to localize the tracts involved in migraine. This is a cross-sectional observational study involving 50 subjects (30 patients of migraine diagnosed as per ICHD-III and 20 age and sex matched controls). DTI was performed on 3T MRI and the mean diffusivity and fractional anisotropy values of the cases were compared with controls.

Results and Conslusion:
Significant changes were noted in the multiple white matter tracts implicated in pain processing compared to the controls. Significant association was also noted between the DTI parameters and the type and frequency of migraine. DTI can thus assist in the diagnosis, assessing the extent of neurological damage in patients of migraine and follow up post treatment.
Implementasi Live Recording Motion Tracking pada Pergerakan Karakter Animasi 2D
Authors: Satria Dhimas , Rifai Ahmad Musthofa  , Muhammad Haitami Anwari  
Published: December 2024

Animasi 2D saat ini masih diminati dan diproduksi oleh berbagai negara. Banyak teknik - teknik yang dikembangkan pada animasi 2D seperti teknik yang umum yaitu frame by frame dan cut out yang memiliki keunggulan dan kekurangan masing masing. Seiring berkembangnya teknologi beberapa teknik baru mulai dikembangkan, salah satunya adalah teknik motion tracking. Motion tracking adalah sebuah cara untuk merekam pergerakan suatu objek tertentu dalam scene dengan menggunakan kamera. Proses perekaman gerakan tersebut meliputi sumbu X dan Y pada objek 2 Dimensi, serta sumbu X, Y, dan Z pada objek 3 Dimensi. Dalam penelitian ini akan dilakukan pemodelan karakter animasi 2D yang akan digerakan menggunakan perekaman kamera dan nantinya akan direkam menggunakan aplikasi Live2D dengan menerapkan teknik motion tracking sehingga akan didapatkan kemudahan dan keunggulan dalam penggunaan teknik tersebut khususnya pada gerakan-gerakan yang dapat dijangkau pada animasi 2D.
Pengaruh Model Pembelajaran Project Based Learning (PJBL) Terhadap Minat Dan Hasil Belajar Siswa di SMAN 1 Driyorejo
Authors: Firstanda Hanyra , Hidayah Wiladia , Firnanda Alifia , Zahroh Icha , Wulandari Ayu 
Published: December 2024

Perkembangan teknologi informasi yang pesat dan sifat ilmu pengetahuan yang selalu berubah menuntut sektor pendidikan untuk terus berinovasi dalam metode pembelajarannya. Salah satu pendekatan yang diharapkan dapat menjawab tantangan ini adalah model PjBL, yang merangsang siswa untuk berpartisipasi lebih aktif dalam proses pembelajaran melalui penyelesaian proyek yang memerlukan penalaran logis, kolaborasi, dan penerapan konsep dalam situasi dunia nyata. Penelitian ini menggunakan pendekatan eksperimen dengan menggunakan single group pretest-posttest, dimana 50 siswa kelas XI SMAN 1 Driyorejo dipilih sebagai sampel. Data diperoleh melalui angket skala Likert 5 poin yang mengukur minat dan kinerja akademik siswa sebelum dan sesudah penerapan pembelajaran berbasis proyek. Hasil analisis menunjukkan adanya peningkatan yang nyata pada minat dan hasil belajar siswa setelah penerapan PjBL. Dengan demikian, model PjBL terbukti mampu meningkatkan motivasi belajar dan pemahaman siswa terhadap materi pelajaran.