bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Structural Model of Relationships between Stressful Life Events and Older Adults’ Loneliness: Religious Orientation as Mediator
Authors: Yaghubi Hassan 
Published: April 2020

Background: Loneliness is an issue, among many, faced by older adults through stressful life events, which may lead them to unbalanced life.Goals: This study aimed to construct a structural model of associations between stressful life events and older adults’ loneliness, with religious orientation functioning as a mediator.Methods: This correlational-descriptive survey involved participants over 60 nursing homes in Hamedan, who were selected by convenience sampling. The tools utilized in this study were the Paykel Life Events Questionnaire, the Allport-Ross Religious Orientation Scale, and the Short Version of the Social and Emotional Loneliness Scale for Adults (SELSA-S). Data analysis was performed through statistical tests of path analysis and Pearson correlation coefficient.Results: The sample is composed of 92 participants (40 females). Results showed that stressful life events and loneliness have significantly positive and negative relationships, respectively, to religious orientation. Moreover, religious orientation played a mediating role in the association pattern between stressful life events and loneliness. Discussion: These results suggest that although stressful events perform an important role in older adults’ loneliness, religious orientation as a mediating variable have a crucial place in reducing the loneliness in the old age.
Teoria e prática da etnicidade no Alto Juruá acreano
Authors: Pantoja Mariana Ciavatta , Costa Eliza Mara Lozano , Mauro William Barbosa de Almeida  
Published: April 2020

Este artigo é uma reflexão crítica sobre algumas das bases conceituais com que a antropologia opera ao tratar da constituição de novas “identidades étnicas”, retomando o conceito de “comunidades étnicas” de Max Weber, e tomando como referência o caso recente dos índios Kuntanawa do Acre. Os Kuntanawa reivindicam hoje uma Terra Indígena própria enquanto povo indígena, tendo antes conquistado direitos territoriais enquanto “população tradicional” na Reserva Extrativista do Alto Juruá em cuja criação tiveram papel de destaque. Argumentamos que a formulação de Weber dá pistas para entender processos como esse combinando dimensões que costumam ser tratadas como se fossem inconciliáveis: de um lado, a dimensão pragmática e político-territorial e, de outro, a dimensão ontológica da autoconstituição de comunidades étnicas.
Planta Piloto de Bombas Hidráulicas para la Enseñanza y Aprendizaje de la Mecánica de Fluidos
Authors: Barrios Jair , Ferrer Carlos , Rosillón Kenneth 
Published: April 2020

Este trabajo fue desarrollado con el propósito de fabricar un banco de pruebas de bombas hidráulicas portátil para aplicaciones didácticas para así estudiar el flujo de fluidos y sus características en el cual pudo desarrollar experiencias prácticas en el área de ingeniería, conociendo así como se maneja en el ámbito laboral e industrial el comportamiento de este, Por lo tanto este trabajo desarrollado fue sustentado por teorías de Bombas, Teoría, Diseño y aplicaciones, Maxtais (2009), Ciencia de los materiales, Smith (2001), Resistencia de los Materiales, Mott (2009), Introducción a la Ingeniería, White (2011). Por otra parte, la presente investigación se encontró en la modalidad de proyecto de tipo factible por consiguiente se usó la técnica de recolección de datos, como el manejo de técnicas de estadísticas, observación directa, entre otras. Finalmente, se realizaron procedimientos prácticos para la construcción de la planta piloto, como la de parametrización del diseño del mismo, la selección tanto de materiales como equipos, al igual que el diseño de este plasmado en planos acotados con la utilización de AutoCAD 2015 ®, desarrollando de esta forma las 5 etapas u fases de la fabricación de esta herramienta de estudio las cuales fueron validada por razón de la presión de operación, desempeño, cabezal y robustez de este.
La dirección en la gestión del conocimiento incide en el capital intelectual de las instituciones de educación superior del Ecuador
Authors: Jama Z. Victor R. 
Published: April 2020

La dirección es sin duda una de las tareas que con prioridad deben atender las universidades una de las variables gestión del conocimiento. En este contexto el presente estudio se relaciona con las variables gestión del conocimiento en el proceso administrativo en su etapa de dirección y la variable capital intelectual. El objetivo planteado en este estudio fue determinar como la dirección de la gestión del conocimiento incide en el capital intelectual en las instituciones de educación superior de la zona 4 del Ecuador. La investigación es de tipo básica – longitudinal, empleando conjuntamente la exploración documental, histórico, transversal y correlacional. La metodología usada fue la recopilación de información obtenida a través de matrices de datos aplicadas a las unidades de análisis investigadas. Las dimensiones que más influyen en la variable gestión del conocimiento son la dirección y el control, en cuanto a la variable capital intelectual la dimensión que más interviene es el capital humano.
Exoplanets in the Antarctic Sky. III. Stellar Flares Found by AST3-II (CHESPA) within the Southern CVZ of TESS
Authors: Liang En-Si , Zhang 张 Hui 辉 , Yu Zhouyi , Yang Ming , Zhou Ji-lin , Ashley Michael C. B. , Cui Xiangqun , Du Fujia , Fu Jianning , Gong Xuefei , Gu Bozhong , Hu Lei , Hu Yi , Jiang Peng , Liu Huigen , Lawrence Jon , Liu Qiang , Li Xiaoyan , Li Zhengyang , Ma Bin , Mould Jeremy , Shang Zhaohui , Sun Tianrui , Suntzeff Nicholas B. , Tao Charling , Tian Qiguo , Tinney C. G. , Uddin Syed A. , Wang Lifan , Wang Songhu , Wang Xiaofeng , Wei Peng , Wright Duncan , Wu Xuefeng , Wittenmyer Robert A. , Xu Lingzhe , Yang Shihai , Yu Ce , Yuan Xiangyan , Zheng Jessica , Zhou Hongyan , Zhu Zhenxi 
Published: April 2020

Abstract
The CHinense Exoplanet Searching Program from Antarctica is a ground-based wide-field photometric survey using the AST3 and CSTAR telescopes located at Dome A, Antarctica. Blessed with the unparalleled observing conditions on the highest point of the Antarctic plateau, three remotely controlled, fully automatic telescopes (AST3-I, AST3-II, and CSTAR-II) carried out continuous high-precision photometric surveys through the polar nights of 2016 and 2017. During the observing seasons of 2016, a total of 26,578 light curves were obtained for stars within the area of the southern continuous viewing zone of TESS, covering an i-band magnitude range from 7.5 to 15. At m

i
= 10, photometric precision reaches ∼2 mmag, allowing possible discoveries of sub-Jupiter-size exoplanets. Here we report 20 stellar flares with i-band energies larger than 1034 erg detected in the 2016 data set of AST3-II, all from different sources. We model the stellar flares and calculate the durations, amplitudes, energies, and skewnesses. The flare properties and the stellar properties of their sources are presented in this work.
First report of the root parasite Cansjera rheedei (Santalales: Opiliaceae) in Taiwan
Authors: Chen Po-Hao , Chung An-Ching , Yang Sheng-Zehn 
Published: April 2020

The family Opiliaceae in Santalales comprises approximately 38 species within 12 genera distributed worldwide. In Taiwan, only one species of the tribe Champereieae, Champereia manillana, has been recorded. Here we report the first record of a second member of Opiliaceae, Cansjera in tribe Opilieae, for Taiwan.
The newly-found species, Cansjera rheedei J.F. Gmelin (Opiliaceae), is a liana distributed from India and Nepal to southern China and western Malaysia. This is the first record of both the genus Cansjera and the tribe Opilieae of Opiliaceae in Taiwan. In this report, we provide a taxonomic description for the species and colour photographs to facilitate identification in the field.
Multiparametric positron emission tomography/magnetic resonance imaging in nasopharyngeal carcinoma
Authors: Chan Sheng-Chieh , Ng Shu-Hang , Yeh Chih-Hua , Chang Kai-Ping 
Published: April 2020

Objectives:
The clinical significance of positron emission tomography/magnetic resonance imaging (PET/MRI) functional parameters in nasopharyngealcarcinoma (NPC) remains unclear. The purpose of this prospective study was two-fold: (1) to investigate the associations between simultaneously acquired PET/MRI perfusion, diffusion, and glucose metabolism parameters in patients with NPC and (2) to analyze their predictive value with respect to treatment failure.

Materials and Methods:
We enrolled 85 patients with primary NPC who simultaneously underwent18F-fluorodeoxyglucose PET/CT and PET/MRI before definitive treatment. The following variables were determined: (1) functional parameters from the MRI component, including perfusion values (Ktrans
,kep
,ve
, and initial area under the enhancement curve) and apparent diffusion coefficient (ADC) values, and (2) PET parameters, including metabolic tumor volume (MTV). The reciprocal interrelationships between these parameters and their correlations with treatment failure were examined.

Results:
We observed significant negative associations between Ktrans
and ADC (r = −0.215, P = 0.049) as well as between ve and ADC (r = −0.22, P = 0.04). Correlations between PET and MRI functional parameters were not statistically significant. Treatment failures were observed in 21.2% of patients without distant metastases. Multivariate analysis identified ve
as a significant independent predictor for treatment failure (P = 0.022), whereas MTV showed a borderline significance (P = 0.095). Patients in whom both ve
and MTV values were increased had a significantly higher rate of treatment failure (62.5%) than those with either one (21.9%) or no (7.7%) increased parameter (P = 0.004).

Conclusion:
Correlation analyses revealed complex interrelationships among PET and MRI indices measured in patients with NPC. These parameters may have a complementary role in predicting treatment failure in this clinical setting.
Pharmacovigilance in Ayurveda
Authors: Tripathi Arunabh , Sharma Rohit , Mitra Achintya , Ravte Rohit K , Hazra Jayram , Ram T Saketh 
Published: April 2020

Aim:To review the intrinsic tenants available for safe drug usage in Ayurveda and to contextualize the statistical signal detection techniques of current times in terms of Ayurvedic pharmacovigilance program.Materials and methods:Streamlining the information to develop a database that differentiates between known adverse drug reactions (ADRs) from hitherto unknown drug reactions per the standard definition of ADR. To introduce amicable statistical methods viz., Chi-square test, odds ratio (OR), and logistic regression for signal detection.Results and conclusion:The proposed method of developing a known ADR and safe drug usage practices described in Ayurveda that followed the application of standard operating procedures for signal detection as per the pharmacovigilance program by applying statistical methods suggested will ensure pragmatic signal detection.
Medicinal Plants
Authors: Suryavanshi Amrita , Kumar Suresh , Kain Dolly 
Published: April 2020

Introduction:
In the recent decades, diabetes mellitus has emerged as a major health problem in the world and it is hampering the development economically and socially. Indeed, about 80% of the masses in the developing countries depend upon ancient systems of herbal formulations for their primary health concerns. Plants-based drugs and their constituents play a pivotal role in prevention and treatment of various diseases and are considered as rich resources that can be used in drug development and synthesis in future. The purpose of this systematic review is to analyze hypoglycemic properties of medicinal plants.

Aim:
The study is primarily focused to understand the historical and modern documentation related to treatment of diabetes and also to create the attention of pharmacologists, botanists, and phytochemists for further scientific research in the field.

Results:
This present review mainly focuses on 50 medicinal plants with hypoglycemic properties. Various research papers and studies have been reviewed on the role of diverse active chemical biomolecules associated with antidiabetic properties.

Conclusion:
Since time immemorial, plants have been the potential source of medicine and therefore the novel form of healthcare known. The hypoglycemic properties of medicinal plants verified by several researchers have confirmed the effective management of diabetes mellitus. This study concluded that the profiles of plant species were generally used for treatment of disease and having antidiabetic properties can be an effective source for the development of safer oral hypoglycemic agents.
Tenure Trends in Academic Emergency Medicine Departments in U.S. Medical Schools
Authors: Xierali Imam M. , Nivet Marc A. 
Published: April 2020

AbstractObjectiveThe objective was to assess the long‐term trends in tenure status stratified by sex and underrepresented in medicine (URM) status among emergency medicine (EM) department faculty in U.S. medical schools.MethodsThis study used the Association of American Medical Colleges Faculty Roster to study trends in tenure status of full‐time faculty from 1989 to 2018. The numbers and proportions of faculty by tenure status were studied over the years and compared across sex and URM minority status. Two‐independent‐sample t‐test and simple linear regression were used for statistical comparisons.ResultsThe number of EM faculty increased from 177 in 1989 to 5,237 in 2018, with the majority of increase in nontenured (from 120 to 4,485) rather than tenured (from 24 to 198) or tenure track (from 28 to 548) faculty. The proportions of tenure‐line faculty increased briefly from 1989 (29.4%) to 1994 (32.5%) and decreased since to 14.2% in 2018. The decreases were greater among men (from 34.5% to 14.9%) or non‐URM (from 32.7% to 14.1%) than women (from 24.8% to 13.1%) or URM (from 30.2% to 15.3%). Compared to other academic departments, EM departments had the second lowest proportion of tenure‐line faculty in 2018.ConclusionEmergency medicine faculty size increased rapidly in the past 30 years, with the vast majority of growth in nontenured faculty, regardless of sex or URM status. This highlights the need to review career development and academic promotions for EM particularly among nontenured faculty.
Fortschritte bei aktivitätsbasierten Sonden für die isoformselektive Bildgebung enzymatischer Aktivität
Authors: Gardner Sarah H. , Reinhardt Christopher J. , Chan Jefferson 
Published: April 2020

AbstractBis vor kurzem gab es keine allgemeinen Methoden zur Abschätzung der Auswirkungen post‐translationaler Regulierung auf die Enzymaktivität. Aktivitätsbasierte Sensorik (ABS) hat sich zu einem leistungsfähigen Ansatz zur Beobachtung der Aktivitäten von niedermolekularen Verbindungen und Enzymen in lebenden Systemen entwickelt. Erste ABS‐Beispiele wurden genutzt, um allgemeine Enzymaktivität zu messen, jedoch hat sich der Fokus in letzter Zeit zum Erhöhen der Selektivität für die Beobachtung eines einzelnen Enzyms oder einer einzelnen Isoform hin verschoben. Hohe Selektivität wird benötigt, um zwischen verschiedenen Isoformen eines Enzyms zu unterscheiden, da diese infolge von Genduplikation oder alternativem Spleißen signifikante Strukturähnlichkeiten aufweisen. Dieser Kurzaufsatz diskutiert Schlüsselbeispiele von niedermolekularen, isoformselektiven Sonden, wobei der Fokus auf die Relevanz von Isoformunterscheidung, Designstrategien zum Erreichen von Selektivität sowie Anwendungen in der Grundlagenbiologie und dem klinischen Umfeld gelegt wird.
Droplet Precise Self‐Splitting on Patterned Adhesive Surfaces for Simultaneous Multidetection
Authors: Li Huizeng , Fang Wei , Zhao Zhipeng , Li An , Li Zheng , Li Mingzhu , Li Qunyang , Feng Xiqiao , Song Yanlin 
Published: April 2020

AbstractPrecise separation and localization of microdroplets are fundamental for various fields, such as high‐throughput screening, combinatorial chemistry, and the recognition of complex analytes. We have developed a droplet self‐splitting strategy to divide an impacting droplet into predictable microdroplets and deposit them at preset spots for simultaneous multidetection. No matter exchange was observed between these microdroplets, so they could be manipulated independently. Droplet self‐splitting was attributed to anisotropic liquid recoiling on the patterned adhesive surface, as influenced by the droplet Weber number and the width of the low‐adhesive stripe. A quantitative criterion was also developed to judge the droplet self‐splitting capability. The precise separation and distribution of microdroplets enabled simultaneous arrayed reactions and multiple analyte detection using one droplet of sample.
N‐Methylated Peptide Synthesis via Generation of an Acyl N‐Methylimidazolium Cation Accelerated by a Brønsted Acid
Authors: Otake Yuma , Shibata Yusuke , Hayashi Yoshihiro , Kawauchi Susumu , Nakamura Hiroyuki , Fuse Shinichiro 
Published: April 2020

AbstractThe development of a robust amide‐bond formation remains a critical aspect of N‐methylated peptide synthesis. In this study, we synthesized a variety of dipeptides in high yields, without severe racemization, from equivalent amounts of amino acids. Highly reactive N‐methylimidazolium cation species were generated in situ to accelerate the amidation. The key to success was the addition of a strong Brønsted acid. The developed amidation enabled the synthesis of a bulky peptide with a higher yield in a shorter amount of time compared with the results of conventional amidation. In addition, the amidation can be performed by using either a microflow reactor or a conventional flask. The first total synthesis of naturally occurring bulky N‐methylated peptides, pterulamides I–IV, was achieved. Based on experimental results and theoretical calculations, we speculated that a Brønsted acid would accelerate the rate‐limiting generation of acyl imidazolium cations from mixed carbonic anhydrides.
2,4‐Dichlorophenol molecularly imprinted two‐dimensional photonic crystal hydrogels
Authors: Qin Xiatong , Liu Weihao , Liu Genqi , Ren Chenrui , Liu Chenhui , Li Huanhuan , Cao Yunlei 
Published: April 2020

AbstractA novel molecularly imprinted two‐dimensional (2‐D) photonic crystal hydrogels (MIPH) for sensitive and label‐free recognition of 2,4‐dichlorophenol (2,4‐DCP) was prepared. The 2‐D photonic crystal template was fabricated by using air‐water interface self‐assembly method. And then the template was embedded with molecularly imprinted polymer, which was synthesized with 2,4‐DCP as imprinted molecules, dimethyl sulfoxide as solvent, acrylic acid and acrylamide as functional monomers, N,N‐methylene bis acrylamide as cross‐linker, azobisisobutyronitrile as initiator. The imprinted molecules were removed by 0.01 M ammonia solution. The results indicated that the 2,4‐DCP molecularly imprinted 2‐D photonic crystal hydrogels has good response and recognition ability to 2,4‐DCP. When the molar ratio of cross‐linking density of MIPH is 2.3% and the molar ratio of imprinting molecule is 5.0%, the change of Debye ring diameter is the largest. The diameter of Debye ring increased by 7.1 mm when the concentration of 2,4‐DCP changed from 0 to 1 × 10−6 M, and the particle spacing of MIPH reduced 38 nm. In addition, the diameter of the Debye ring hardly changed in the solution of analogues of 2,4‐DCP such as, phenol, 2‐chlorophenol, 2,4,6‐trichlorophenol and so on, indicating that the MIPH has highly sensitivity and specificity.
Micro‐RNA29b enhances the sensitivity of glioblastoma multiforme cells to temozolomide by promoting autophagy
Authors: Xu Jing‐Xuan , Yang Yan , Zhang Xu , Luan Xin‐Ping 
Published: April 2020

AbstractTo explore whether or not aberrant expression of miR‐29b in glioblastoma multiforme (GBM) cells was associated with temozolomide (TMZ) resistance and to elucidate potential underlying mechanisms. Upregulation of miR‐29 in GBM cells was achieved by transfecting miR‐29b mimics. Changes in cell viability were measured by using CCK‐8 assays. Flow cytometry and TUNEL assays were used to quantify the number of apoptotic cells. The expression levels of apoptosis‐related proteins as well as autophagy‐associated proteins, and the expression levels of both apoptotic and autophagic genes were determined by Western blotting. Autophagy flux was monitored by transfecting mRFP‐GFP‐LC3 adenovirus. We halted autophagy by introducing Atg 5‐specific siRNA or the autophagy inhibitor Bafilomycin A1 (Baf‐A1). We also employed a GBM xenograft mice model to confirm the role of miR‐29b in vivo. miR‐29b overexpression induced inhibition of cell viability, and also induced apoptosis and autophagy in U251 and U87MG cells. Furthermore, upregulation of miR‐29b was able to potentiate the level of antitumor activity of TMZ against tested cells. We also found that autophagy induced by miR‐29b, at least partially, contributed to the increase of TMZ sensitivity in GBM cells. As was evidenced by blockade of autophagy, the application of Atg 5 siRNA or Baf‐A1 was able to significantly reverse these effects. Consistent with observations in vitro, findings of in vivo assessment also confirmed that overexpression of miR‐29b was able to effectively halt tumor growth and enhance the antitumor activity of TMZ. miR‐29b potentiates TMZ sensitivity against GBM cells by inducing autophagy and the combined use of miR‐29 mimic and TMZ might represent a potential therapeutic strategy for GBM patients.
Hypothermia from a two‐component mixture comprising Amoxicillin and Sulbactam
Authors: Dinh Duong Tung Anh , Hoang Ngoc Anh , Doan Thi Linh , Bui Thi Dung , Pham Thi Huong , Nguyen Ngoc Sang , Bui Van Chien , Dinh Van Thuc 
Published: April 2020

AbstractHypothermia might be an adverse effect of Amoxicillin and/or Sulbactam, and clinicians should be aware of this effect. Further clinical and laboratory investigations are also needed to confirm and clarify the underlying mechanism of this side effect.
Nitrogen‐Doped Porous Carbon Cages for Electrocatalytic Reduction of Oxygen: Enhanced Performance with Iron and Cobalt Dual Metal Centers
Authors: Mercado Rene , Wahl Carolin , En Lu Jia , Zhang Tianjun , Lu Bingzhang , Zhang Peng , Lu Jennifer Q. , Allen A'Lester , Zhang Jin Z. , Chen Shaowei 
Published: April 2020

AbstractHeteroatom‐doped carbon materials are promising electrocatalysts towards the oxygen reduction reaction (ORR). In this study, dual metals (Fe an Co) and nitrogen‐codoped porous carbon cages (CHS−FeCo) were synthesized by controlled pyrolysis of silica nanoparticle‐supported melamine‐formaldehyde resin embedded with iron and cobalt precursors, followed by acid etching. Transmission electron microscopy measurements confirmed the formation of hollow carbon cages, and the absence of metal (oxide) nanoparticles suggested atomic dispersion of the metal species within the mesoporous carbon skeletons. X‐ray photoelectron spectroscopic analysis revealed a composition of mostly carbon, oxygen, and nitrogen, with ca. 1 % metals. Electrochemically, the dual‐metal ones showed a significant enhancement of the catalytic performance towards ORR in alkaline media, as compared to samples with single or no metal dopants. This was accounted for by the synergistic interaction between the Fe and Co centers in the carbon samples, as evidenced in X‐ray absorption spectroscopic studies. Remarkably, the CHS−FeCo sample exhibited apparent resistance against KSCN poisoning, where XPS analysis revealed oxidation of KSCN and no metal‐sulfur interaction, in sharp contrast to the Fe counterpart which was easily poisoned. Results from this study suggest that the synergistic interactions between dual metal centers may be exploited for enhanced ORR performance of carbon‐based nanocomposite catalysts.