bluuebunny/crossref_metadata_2025_split huggingface dataset:
Podcasts as a teaching tool in orthopaedic surgery
Authors: Schöbel Tobias , Zajonz Dirk , Melcher Peter , Lange Johannes , Fischer Benjamin , Heyde Christoph-E. , Roth Andreas , Ghanem Mohamed 
Published: August 2020

Abstract
Objective
The aim of this study was to evaluate the influence of the introduction of online podcasts as part of the main lecture series in orthopaedics on the number of lecture attendees, the examination results and the assessment of teaching by the students. Additionally, we evaluated the use of other media for examination preparation.

Methodology
At the beginning and end of the lecture series questionnaires were handed out to the students to evaluate their attitudes towards attending lectures, the use of video podcasts and examination preparation. In addition, the number of lecture attendees and podcast usage during the semester were counted and the statements of the students in the evaluation assessments of orthopaedic teaching were evaluated. The examination results were correlated in a statistical analysis with the learning materials provided by the students for examination preparation.

Results
At the end of the lecture series, 284 students stated that they used the lecture podcast about twice as often as attending lectures; however, for the majority of the students the provision of a video podcast was no reason not to attend the lecture. For example, 37.2% stated that they never and 26.8% stated that they rarely had not attended the lecture by providing the podcasts. Of the students 91–95% considered the availability of lecture podcasts to be a rather meaningful or very meaningful supplement to the lecture visit. Students increasingly used digital media to prepare for examinations instead of using traditional analogue methods. None of the learning methods or materials examined showed a statistically significant advantage in examination results.

Conclusion
Students in the age of digitalization use a variety of learning materials and are no longer bound to classical analog teaching methods. The use of online podcasts had no negative impact on examination performance. Most students perceived lecture podcasts as a useful supplement to lecture attendance. The students praised the expansion of the teaching curriculum to include additional digital offers with positive comments in the evaluations, but without achieving an improvement in these student evaluations.
Short neuropeptide F signaling regulates functioning of male reproductive system in Tenebrio molitor beetle
Authors: Marciniak Paweł , Urbański Arkadiusz , Lubawy Jan , Szymczak Monika , Pacholska-Bogalska Joanna , Chowański Szymon , Kuczer Mariola , Rosiński Grzegorz 
Published: August 2020

AbstractNeuropeptides of short neuropeptides F family (sNPF) have been identified in various arthropods. They are pleiotropic neuromolecules which so far have been mainly associated with regulation of feeding and metabolism, as well as growth and development, locomotion, circadian rhythm or learning and memory. Here, we describe the effects of Tenebrionid sNPF peptide (SGRSPSLRLRFa) on various aspects of the male reproductive physiology in the Tenebrio molitor beetle. We identified in silico the putative sNPF receptor Tenmo-sNPFR. Based on RT-PCR technique, it was shown that the receptor might be present in the male reproductive tissues of this beetle. The analysis of receptor amino acid sequence showed that it is similar to other beetle sNPFRs, as well as other insect species, and belongs rhodopsin-like G-protein-coupled receptors (GPCRs). Injections of Trica-sNPF and its shorter form Trica-sNPF(4–11) caused differentiated effects in T. molitor male reproductive tissues. After 24 h post injections, the peptides decreased the concentration of the soluble protein fraction in testes of 4- and 8-day-old beetles as well as the dry mass of these organs but only in 8-day-old individuals. The same effects were shown with regard to accessory glands. Both peptides decrease the concentration of the soluble protein fraction but do not affect the dry mass of this organ. Furthermore, injections of Trica-sNPF at the 10–7 M concentration decrease the total sperm number in the reproductive system. Surprisingly, the same concentration of the shorter form, Trica-sNPF(4–11) increased the sperm number. It was also shown that both peptides in different manner influence contractions of ejaculatory duct. The data presented in this article give new evidence that sNPFs are involved in the regulation of reproductive events in beetles, which might be the part of a larger neuropeptide network combining feeding, growth and development with the physiology of reproduction.
Dynamic Scaling of the Generalized Complementary Relationship Improves Long-term Tendency Estimates in Land Evaporation
Authors: Szilagyi Jozsef , Crago Richard , Ma Ning 
Published: August 2020

AbstractMost large-scale evapotranspiration (ET) estimation methods require detailed information of land use, land cover, and/or soil type on top of various atmospheric measurements. The complementary relationship of evaporation (CR) takes advantage of the inherent dynamic feedback mechanisms found in the soil-vegetation-atmosphere interface for its estimation of ET rates without the need of such biogeophysical data. ET estimates over the conterminous United States by a new, globally calibrated, static scaling (GCR-stat) of the generalized complementary relationship (GCR) of evaporation were compared to similar estimates of an existing, calibration-free version (GCR-dyn) of the GCR that employs a temporally varying dynamic scaling. Simplified annual water balances of 327 medium and 18 large watersheds served as ground-truth ET values. With long-term monthly mean forcing, GCR-stat (also utilizing precipitation measurements) outperforms GCR-dyn as the latter cannot fully take advantage of its dynamic scaling with such data of reduced temporal variability. However, in a continuous monthly simulation, GCR-dyn is on a par with GCR-stat, and especially excels in reproducing long-term tendencies in annual catchment ET rates even though it does not require precipitation information. The same GCR-dyn estimates were also compared to similar estimates of eight other popular ET products and they generally outperform all of them. For this reason, a dynamic scaling of the GCR is recommended over a static one for modeling long-term behavior of terrestrial ET.
Nerve ultrasound in hereditary transthyretin amyloidosis: red flags and possible progression biomarkers
Authors: Salvalaggio Alessandro , Coraci Daniele , Cacciavillani Mario , Obici Laura , Mazzeo Anna , Luigetti Marco , Pastorelli Francesca , Grandis Marina , Cavallaro Tiziana , Bisogni Giulia , Lozza Alessandro , Gemelli Chiara , Gentile Luca , Ermani Mario , Fabrizi Gian Maria , Plasmati Rosaria , Campagnolo Marta , Castellani Francesca , Gasparotti Roberto , Martinoli Carlo , Padua Luca , Briani Chiara 
Published: August 2020

Abstract
Background
Diagnostic delay of hereditary transthyretin amyloidosis (ATTRv, v for variant) prevents timely treatment and, therefore, concurs to the mortality of the disease. The aim of the present study was to explore with nerve ultrasound (US) possible red flags for early diagnosis in ATTRv patients with carpal tunnel syndrome (CTS) and/or polyneuropathy and in pre-symptomatic carriers.

Methods
Patients and pre-symptomatic carriers with a TTR gene mutation were enrolled from seven Italian centers. Severity of CTS was assessed with neurophysiology and clinical evaluation. Median nerve cross-section area (CSA) was measured with US in ATTRv carriers with CTS (TTR-CTS). One thousand one hundred ninety-six idiopathic CTS were used as controls. Nerve US was also performed in several nerve trunks (median, ulnar, radial, brachial plexi, tibial, peroneal, sciatic, sural) in ATTRv patients with polyneuropathy and in pre-symptomatic carriers.

Results
Sixty-two subjects (34 men, 28 women, mean age 59.8 years ± 12) with TTR gene mutation were recruited. With regard to CTS, while in idiopathic CTS there was a direct correlation between CTS severity and median nerve CSA (r = 0.55, p < 0.01), in the subgroup of TTR-CTS subjects (16 subjects, 5 with bilateral CTS) CSA did not significantly correlate with CTS severity (r = − 0.473). ATTRv patients with polyneuropathy showed larger CSA than pre-symptomatic carriers in several nerve sites, more pronounced at brachial plexi (p < 0.001).

Conclusions
The present study identifies nerve morphological US patterns that may help in the early diagnosis (morpho-functional dissociation of median nerve in CTS) and monitoring of pre-symptomatic TTR carriers (larger nerve CSA at proximal nerve sites, especially at brachial plexi).
Effect of Bridge Position Swallow on Esophageal Motility in Healthy Individuals Using High-Resolution Manometry
Authors: Aoyama Kei , Kunieda Kenjiro , Shigematsu Takashi , Ohno Tomohisa , Fujishima Ichiro 
Published: August 2020

AbstractRecently, there has been clinical interest in the effect of different body positions on esophageal motility. This study aimed to identify the effect of three different body positions on esophageal motility using high-resolution manometry. Thirteen healthy adults swallowed 5 mL of water in the upright, supine, and bridge positions. For the bridge position, each subject raised their waist against gravity, placed a cushion under their back, and bent their knees. The proximal contractile integral (PCI) and distal contractile integral (DCI), integrated relaxation pressure (IRP), distal latency (DL), peristaltic breaks (PBs), intrabolus pressure (IBP), and expiratory and inspiratory esophagoesophageal junction (EGJ) pressure were measured. In the bridge position, PCI, DCI, IRP, and expiratory and inspiratory EGJ pressure were significantly higher than those in the upright position (bridge PCI vs. upright PCI [p = 0.001], bridge DCI vs. upright DCI [p < 0.001], bridge IRP vs. upright IRP [p = 0.018], bridge EGJ pressure vs. upright EGJ pressure [expiratory: p = 0.001] [inspiratory: p < 0.001]). PBs were significantly shorter and DL was significantly longer in the bridge position compared to upright (bridge PBs vs. upright PBs [p = 0.001], bridge DL vs. upright DL [p = 0.001]). IBP was significantly higher in the bridge position compared to supine (bridge IBP vs. supine IBP [p = 0.01]). These results demonstrated changes in esophageal motility according to changes in position while swallowing, where esophageal contractions became stronger against gravity. Further study is required to examine the effectiveness of swallowing in the bridge position.
Epigenetic Regulation of Endothelial Cell Function by Nucleic Acid Methylation in Cardiac Homeostasis and Disease
Authors: Russell-Hallinan Adam , Watson Chris J. , O’Dwyer Denis , Grieve David J. , O’Neill Karla M. 
Published: August 2020

AbstractPathological remodelling of the myocardium, including inflammation, fibrosis and hypertrophy, in response to acute or chronic injury is central in the development and progression of heart failure (HF). While both resident and infiltrating cardiac cells are implicated in these pathophysiological processes, recent evidence has suggested that endothelial cells (ECs) may be the principal cell type responsible for orchestrating pathological changes in the failing heart. Epigenetic modification of nucleic acids, including DNA, and more recently RNA, by methylation is essential for physiological development due to their critical regulation of cellular gene expression. As accumulating evidence has highlighted altered patterns of DNA and RNA methylation in HF at both the global and individual gene levels, much effort has been directed towards defining the precise role of such cell-specific epigenetic changes in the context of HF. Considering the increasingly apparent crucial role that ECs play in cardiac homeostasis and disease, this article will specifically focus on nucleic acid methylation (both DNA and RNA) in the failing heart, emphasising the key influence of these epigenetic mechanisms in governing EC function. This review summarises current understanding of DNA and RNA methylation alterations in HF, along with their specific role in regulating EC function in response to stress (e.g. hyperglycaemia, hypoxia). Improved appreciation of this important research area will aid in further implicating dysfunctional ECs in HF pathogenesis, whilst informing development of EC-targeted strategies and advancing potential translation of epigenetic-based therapies for specific targeting of pathological cardiac remodelling in HF.
Geographic hierarchical population genetic structuring in British European whitefish (Coregonus lavaretus) and its implications for conservation
Authors: Crotti M. , Adams C. E. , Etheridge E. C. , Bean C. W. , Gowans A. R. D. , Knudsen R. , Lyle A. A. , Maitland P. S. , Winfield I. J. , Elmer K. R. , Præbel K. 
Published: August 2020

AbstractThe European whitefish Coregonus lavaretus complex represents one of the most diverse radiations within salmonids, with extreme morphological and genetic differentiation across its range. Such variation has led to the assignment of many populations to separate species. In Great Britain, the seven native populations of C. lavaretus (two in Scotland, four in England, one in Wales) were previously classified into three species, and recent taxonomic revision resurrected the previous nomenclature. Here we used a dataset of 15 microsatellites to: (1) investigate the genetic diversity of British populations, (2) assess the level of population structure and the relationships between British populations. Genetic diversity was highest in Welsh (HO = 0.50, AR = 5.29), intermediate in English (HO = 0.41–0.50, AR = 2.83–3.88), and lowest in Scottish populations (HO = 0.28–0.35, AR = 2.56–3.04). Population structure analyses indicated high genetic differentiation (global FST = 0.388) between all populations but for the two Scottish populations (FST = 0.063) and two English populations (FST = 0.038). Principal component analysis and molecular ANOVA revealed separation between Scottish, English, and Welsh populations, with the Scottish populations being the most diverged. We argue that the data presented here are not sufficient to support a separation of the British European whitefish populations into three separate species, but support the delineation of different ESUs for these populations.
Cross-Country Comparisons of Covid-19: Policy, Politics and the Price of Life
Authors: Balmford Ben , Annan James D. , Hargreaves Julia C. , Altoè Marina , Bateman Ian J. 
Published: August 2020

AbstractCoronavirus has claimed the lives of over half a million people world-wide and this death toll continues to rise rapidly each day. In the absence of a vaccine, non-clinical preventative measures have been implemented as the principal means of limiting deaths. However, these measures have caused unprecedented disruption to daily lives and economic activity. Given this developing crisis, the potential for a second wave of infections and the near certainty of future pandemics, lessons need to be rapidly gleaned from the available data. We address the challenges of cross-country comparisons by allowing for differences in reporting and variation in underlying socio-economic conditions between countries. Our analyses show that, to date, differences in policy interventions have out-weighed socio-economic variation in explaining the range of death rates observed in the data. Our epidemiological models show that across 8 countries a further week long delay in imposing lockdown would likely have cost more than half a million lives. Furthermore, those countries which acted more promptly saved substantially more lives than those that delayed. Linking decisions over the timing of lockdown and consequent deaths to economic data, we reveal the costs that national governments were implicitly prepared to pay to protect their citizens as reflected in the economic activity foregone to save lives. These ‘price of life’ estimates vary enormously between countries, ranging from as low as around $100,000 (e.g. the UK, US and Italy) to in excess of $1million (e.g. Denmark, Germany, New Zealand and Korea). The lowest estimates are further reduced once we correct for under-reporting of Covid-19 deaths.
The Corona-Pandemic: A Game-Theoretic Perspective on Regional and Global Governance
Authors: Caparrós Alejandro , Finus Michael 
Published: August 2020

AbstractWe argue that the incentive structure of all individual and coordinated measures across countries to contain the corona-pandemic is that of a weakest-link public good game. We discuss a selection of theoretical and experimental key results of weakest-link games and interpret them in the light of the corona-pandemic. First, we highlight that experimental evidence does not support the assumption that coordination can be trivially solved, even among symmetric players. Second, we argue that for asymmetric countries the weakest-link game does not only pose a problem of coordination, but also a problem of cooperation. Third, we show how and under which conditions self-enforcing treaties can foster coordination and cooperation. We account for the possibility that countries make mistakes when choosing their actions. Our discussion shows that North–South cooperation is relevant and likely to be self-enforcing and that regional cooperation, e.g., within the EU, will also be important.
The Effects of Air Pollution on COVID-19 Related Mortality in Northern Italy
Authors: Coker Eric S. , Cavalli Laura , Fabrizi Enrico , Guastella Gianni , Lippo Enrico , Parisi Maria Laura , Pontarollo Nicola , Rizzati Massimiliano , Varacca Alessandro , Vergalli Sergio 
Published: August 2020

AbstractLong-term exposure to ambient air pollutant concentrations is known to cause chronic lung inflammation, a condition that may promote increased severity of COVID-19 syndrome caused by the novel coronavirus (SARS-CoV-2). In this paper, we empirically investigate the ecologic association between long-term concentrations of area-level fine particulate matter (PM2.5) and excess deaths in the first quarter of 2020 in municipalities of Northern Italy. The study accounts for potentially spatial confounding factors related to urbanization that may have influenced the spreading of SARS-CoV-2 and related COVID-19 mortality. Our epidemiological analysis uses geographical information (e.g., municipalities) and negative binomial regression to assess whether both ambient PM2.5 concentration and excess mortality have a similar spatial distribution. Our analysis suggests a positive association of ambient PM2.5 concentration on excess mortality in Northern Italy related to the COVID-19 epidemic. Our estimates suggest that a one-unit increase in PM2.5 concentration (µg/m3) is associated with a 9% (95% confidence interval: 6–12%) increase in COVID-19 related mortality.
The Value of Greenspace Under Pandemic Lockdown
Authors: Day Brett H. 
Published: August 2020

AbstractThe COVID-19 outbreak resulted in unprecedented restrictions on citizen’s freedom of movement as governments moved to institute lockdowns designed to reduce the spread of the virus. While most out-of-home leisure activities were prohibited, in England the lockdown rules allowed for restricted use of outdoor greenspace for the purposes of exercise and recreation. In this paper, we use data recorded by Google from location-enabled mobile devices coupled with a detailed recreation demand model to explore the welfare impacts of those constraints on leisure activities. Our analyses reveals evidence of large-scale substitution of leisure time towards recreation in available greenspaces. Indeed, despite the restrictions the economic value of greenspace to the citizens of England fell by only £150 million over lockdown. Examining the outcomes of counterfactual policies we find that the imposition of stricter lockdown rules would have reduced welfare from greenspace by £1.14 billion. In contrast, more relaxed lockdown rules would have delivered an aggregate increase in the economic value of greenspace equal to £1.47 billion.
Expressivism and Explaining Irrationality: Reply to Baker
Authors: Hengst Sebastian 
Published: August 2020

AbstractIn a recent paper in this journal, Derek Baker (Erkenntnis 83(4):829–852, 2018) raises an objection to expressivism as it has been developed by Mark Schroeder (Being for, Oxford University Press, Oxford, 2008). Baker argues that Schroeder’s expressivist (1) is committed to certain sentences expressing rationally incoherent states of mind, and he objects (2) that the expressivist cannot explain why these states would be rationally incoherent. The aim of this paper is to show that Baker’s argument for (1) is unsound, and that (1) is unlikely to be true. This obviates the need to explain the alleged rational incoherence, and so Baker’s objection to Schroeder’s expressivism is undermined.
On the Integration of Agents and Digital Twins in Healthcare
Authors: Croatti Angelo , Gabellini Matteo , Montagna Sara , Ricci Alessandro 
Published: August 2020

AbstractA digital twin is a digital representation of a physical asset reproducing its data model, its behaviour and its communication with other physical assets. Digital twins act as a digital replica for the physical object or process they represent, providing nearly real-time monitoring and evaluation without being in close proximity. Although most of their concrete applications can be found mainly in the industrial context, healthcare represents another relevant area where digital twins can have a disruptive impact. The main research question tackled by this paper is about the integration of digital twins with agents and Multi-Agent Systems (MAS) technologies in healthcare. After providing an overview of the application of digital twins in healthcare, in this paper, we discuss our vision about agent-based digital twins, and we present a first case study, about the application of agent-based digital twins to the management of severe traumas.
Image Matching from Handcrafted to Deep Features: A Survey
Authors: Ma Jiayi , Jiang Xingyu , Fan Aoxiang , Jiang Junjun , Yan Junchi 
Published: August 2020

AbstractAs a fundamental and critical task in various visual applications, image matching can identify then correspond the same or similar structure/content from two or more images. Over the past decades, growing amount and diversity of methods have been proposed for image matching, particularly with the development of deep learning techniques over the recent years. However, it may leave several open questions about which method would be a suitable choice for specific applications with respect to different scenarios and task requirements and how to design better image matching methods with superior performance in accuracy, robustness and efficiency. This encourages us to conduct a comprehensive and systematic review and analysis for those classical and latest techniques. Following the feature-based image matching pipeline, we first introduce feature detection, description, and matching techniques from handcrafted methods to trainable ones and provide an analysis of the development of these methods in theory and practice. Secondly, we briefly introduce several typical image matching-based applications for a comprehensive understanding of the significance of image matching. In addition, we also provide a comprehensive and objective comparison of these classical and latest techniques through extensive experiments on representative datasets. Finally, we conclude with the current status of image matching technologies and deliver insightful discussions and prospects for future works. This survey can serve as a reference for (but not limited to) researchers and engineers in image matching and related fields.