bluuebunny/crossref_metadata_2025_split huggingface dataset:
Internal jugular vein phlebectasia in a one‐year‐old Warmblood stallion
Authors: Vera L. , Muylle S. , van Loon G. , Gatel L. , Martens A. , Vanderperren K. 
Published: April 2020

SummaryInternal jugular vein phlebectasia (IJVP) is a saccular or fusiform dilation of the internal jugular vein without tortuosity. In human patients, it causes an asymptomatic intermittent unilateral swelling in the lower part of the neck. Although the diagnosis can be suggested based on the clinical features, confirmation by imaging techniques is necessary. This report describes the first reported case of IJVP in a one‐year‐old Warmblood horse. The horse was admitted with a large, soft intermittent swelling in the right jugular groove, especially when lowering the head. Ultrasound showed an enlarged vein (10 cm diameter) draining normally towards the heart. Furthermore, contrast‐enhanced CT (CECT) revealed a large distention of the deep venous system on the right side of the neck. Due to uncertain future athletic performance and both the extent and the complexity of the venous dilation, surgical intervention was declined and the horse was subjected to euthanasia. Post‐mortem dissection revealed a small right external jugular vein but a markedly dilated right internal jugular vein (10 cm diameter), which is normally absent in horses. Based on the imaging and necropsy findings, diagnosis of IJVP was made.
The Using of Simulation Modeling to Improve the Efficiency of Garment Production
Authors: Kuzmin P.I. , Mishchenko I.K. , Oshchepkov M.E. 
Published: April 2020

The paper describes the process of developing a discrete-event simulation model of sewing production with consideration of its specific features. The model is developed in the AnyLogic software environment and based on the analysis of specific data of one of the oldest enterprises of the Altai territory, now part of the holding «BTK group» — JSC BMC «Melangist Altai». The direct purpose of using simulation modeling in the activities of enterprises of the garment industry is the optimization of labor costs as a factor in reducing overall costs and improving production efficiency. It is the high costs and, accordingly, prices that are the main reason for the inability of domestic light industry products to compete with inexpensive foreign products.
The results of the study are presented in the form of recommendations to enterprises of garment production to optimize the technological scheme of division of labor by operations, redistribution of labor resources, and maximum load of equipment. Modification of the developed model and its subsequent integration with the automated production management systems used at the enterprise will ensure the functioning of the garment factory at a higher level and create additional conditions for the transition to digital production.
Perceived stress and coping strategies among undergraduate dental students – an institutional based study
Authors: Veeraboina Nagarani , Doshi Dolar , Kulkarni Suhas , Patanapu Shiva Kumar , Danatala Satya Narayana , Srilatha Adepu 
Published: April 2020

Abstract

Background
Coping strategies are highly mediated by the environment, in particular when the person deals with the obstacles and impediments to fulfill their goals. This study aimed to investigate the Perceived Stress and Coping Strategies among Undergraduate Dental Students of Panineeya Institute of Dental Sciences Hyderabad, India.

Materials and Methods
A cross-sectional study was carried out among 267 undergraduate dental students. The survey tool comprised of Perceived Stress Scale (PSS) and Brief COPE Scale along with demographic variables. Statistical analysis was done using SPSS 20.0.

Results
Based on gender, females had high PSS mean scores (23.8±7.3) than males and to overwhelm these stress levels most of the students followed adaptive coping strategies (40.4±7.8) with no significant difference. But, significant difference noted for maladaptive coping dimension “denial” (p=0.004). On comparison between year of study, higher perceived stress was noted among second year students (26.7± 5.8), and least among first years (21.6±7). In order to defeat the stressors most of the second year undergraduate students used adaptive coping strategies. However, highest mean adaptive coping scores were noted among first years (41.6±7.5) and least scores observed among fourth years (38.6±9.2). However, total PSS score showed significant positive correlation (p<0.001) with maladaptive coping strategies.

Conclusion
Females and second year students perceived more stress levels, to overtake those stressors most of them followed adaptive coping strategies. Hence, institutional authorities should take measures to decrease the stress levels and encourage the students to adopt healthy life style such as meditation and exercise to beat their stressors.
Influence of unevened grains of metal on the mechanical properties of seamless hot – rolled pipes.
Authors: Kovaleva I. A. , Khodosovskaya N. A. , Oborov M. V. 
Published: April 2020

Seamless hot – rolled pipes are a popular metal product on the world market. During operation, pipelines are subjected to cyclic loads associated with temperature fluctuations, vibrations near compressor stations, and pressure drops in the transformed medium. One of the ways to ensure high performance properties is to manage the quality of pipe metal, including that laid in the process of metallurgical production. All the basic physical and mechanical properties of metal materials are structurally sensitive and significantly depend on both the grain size and the degree of uniformity of the grain structure, that is, on the different grain sizes. For metallographic research, samples of pipes with the size of 70,0×12,5 mm of S460NH steel were selected with satisfactory (#1) and unsatisfactory (#2) results of the impact. It was found that the inhomogeneous (multi – grained) microstructure in sample #2 was the reason for obtaining unsatisfactory results of the impact. As a result, it was found that one of the most important characteristics that can guarantee stable and satisfactory results of mechanical characteristics, in particular the impact performance, is a homogeneous grain structure.
Rapid Phenotypic Detection of Gram-negative Bacilli Resistant to Oximinocephalosporins and Carbapenems in Positive Blood Cultures Using a Novel Protocol
Authors: Josa Diego , Bustos Ingrid Gisell , Yusef Soad Amira , Crevoisier Stephanie , Silva-Monsalve Edwin , López-Moreno Natalia , Avendaño Rafael Leal , Molina Isabel Torres , Osorio Juan Pablo , Arias-Leon Gerson , Cortés Fabián , Sánchez Carolina , Reyes Luis Felipe 
Published: April 2020

Abstract
Aim: To test a modified protocol designed to detect Gram-negative bacilli (GNB) resistant to oximinocephalosporins and carbapenems from positive blood cultures. Design: This is a prospective, cohort study of consecutive patients. Setting: A cardiovascular and University referral hospital. Patients: Patients hospitalized in a third level hospital with bacteraemia. Main variables of interest: We developed a modified protocol using HB&L® system to detect MDRP. We then attempted to determine accuracy, concordance and reduction of identification time of this novel method in a reference hospital. Descriptive statistics and logistical regressions were used. Results: Ninety-six patients with BSI were included in the study. A total of 161 positive blood cultures were analysed. Escherichia coli (50%, 81/161) was the most frequently identified pathogen followed by Klebsiella pneumoniae (15%, 24/161) and Pseudomonas aeruginosa (8%, 13/161). Thirty-two percent of isolations had usual resistance patters. However, in 34/161 (21%) of identified pathogens were producer of carbapenemasases and 21/161 (13%) of extended-spectrum β-lactamases. Concordance among our HB&L®modified protocol and traditional method was 99% (159/161). Finally, identification times were significantly shorter using our HB&L® modified protocol than traditional methods (Median [IQR]; 19 hours [18, 22] Vs 61 hours [60, 64], p<0.001). Conclusions: Here we provided novel evidence that using our HB&L® modified protocol is an effective strategy to reduce the time to MDRP detection/identification; with a great concordance rate when compared to the gold standard. Further studies are needed to confirm these findings and to determine whether this method may improve clinical outcomes.
Orlistatand and Rosuvastatin Suppressed Proliferation of K562 Human Myelogenous Leukemia Cell Line through AMPK/Akt/c-Myc Signaling
Authors: Mojjarad Behnam , Pazhang Yaghub 
Published: April 2020

Abstract
Background: Chronic myeloid leukemia is a myeloproliferative cancer with worldwide incidence, has become as a clinical concern due to chemoresistance in the patients received chemotherapy. Here, we investigated the effect of Orlistat and Rosuvastatin on K562 human myelogenous leukemia cell line in vitro and attempted to illuminate their possible underlying mechanisms. Methods: Cells were exposed to Orlistat and Rosuvastatin, the inhibitors of lipogenesis, then survival and apoptosis rate of K562 cells were examined by MTT assay and flow cytometric analysis respectively. The real time-PCR analysis was used to quantify mRNA levels of Bax, Bcl-2, and Hsp-70 genes. Cell cycle analysis was performed using flow cytometry, whereas the subcellular distribution of c-Myc was measured via immunofluorescence imaging technique. Additionally, the protein level of AMPK, p-AMPK Akt-1, and p-Akt-1 were studied by western blotting. Results: The results showed Orlistat and Rosuvastatin had synergistic anticancer effects on cells and in comparison with the control group, viability and apoptosis rate decreased and increased in treated cells respectively in a dose/time-dependent manner (P<0.05). The mRNA levels of Bax increased while expression of Hsp-70 decreased (P< 0.05). K562 cells treated with Orlistat and Rosuvastatin showed a cell cycle arrest in sub-G1 phase and a decreased level of c-Myc positive cells. Upon outlining the mechanism, it was revealed that AMPK/p-AMPK and p-Akt-1/Akt-1 ratio decreased in treated cells (P< 0.05). Conclusions: Data suggest Orlistat and Rosuvastatin could synergically suppress proliferation of K562 cells through AMPK/Akt/c-Myc axis, proposing a theoretical basis for upcoming application in the treatment of chronic myeloid leukemia
Time-frequency Dependency of Exchange Rate and Non-performing Loan in Turkey
Authors: Kirikkaleli Dervis , Torun Melike 
Published: April 2020

Abstract
The two-way linkage between non-performing loans (NPL) and the US dollar-Turkish lira exchange rate (USD/TRY) (ER) is explored in Turkey using quarterly data from 1995Q1 to 2017Q4 using wavelet coherence technique. The findings of this study indicate that: (i) significant vulnerability in NPL is detected between 1999 and 2004, while ER significantly fluctuated during the period between 2001 and 2003 and the 2008 global crisis period in the short run; (ii) ER has a strong power to explain NPL at difference frequencies; (iii) NPL and ER were positively correlated in Turkey during the global crisis period.
Phenotypes of Obstructive Lung Diseases in Elderly: A Real-Life Study in a Non-Clinical Setting
Authors: Gaspar-Marques João , Caires Iolanda , Palmeiro Teresa , Pinto Paula Leiria , Chasqueira Maria-Jesus , Paixão Paulo , Botelho Maria-Amalia Amália , Ferreira António Jorge , Annesi-Maesano Isabella , Neuparth Nuno , Carreiro-Martins Pedro 
Published: April 2020

Abstract
Background: This study aimed to characterize the clinical, functional, inflammatory and immunological features of the main obstructive lung diseases (OLD) in elderly. Methods: We included subjects aged ≥ 65 years. In Phase I, participants answered standardized questionnaires, performed spirometry, fractional exhaled nitric oxide, an atopy assessment and blood analysis. In Phase II, patients with COPD or asthma criteria and a control group were invited to undergo a more detailed evaluation that included the determination of IL-1-β, IL-5, IL-6, IL-13, TNF-α and periostin. In Phase III was assessed the frequency of non-scheduled medical visits due to respiratory exacerbations, hospitalization and mortality. Results: Phase I included 286 participants. The median age was 85.8 (P27-P75: 81.0 - 90.2) years and 69% were females: 27.3% had chronic obstructive pulmonary disease (COPD) without asthma (Group 1), 2.8% asthma without COPD (Group 2) and 5.2% presented asthma and COPD traits (Group 3). The remaining participants (64.7%), without asthma or COPD, were classified as Group 4. At this stage, Group 3 was more atopic and presented a lower post-bronchodilator FEV 1 and FEV 1 /FVC. In Phase II, that included 82 participants, Group 3 presented the higher median values of TNF-α (p-value: 0.072) and higher lung volumes (p=0.001). No statistically differences were found for other cytokines among groups. In Phase III, Group 3 patients needed more non-scheduled visits. Conclusions: In our study patients with asthma and COPD traits presented more severe airflow limitation, higher values of TNF-α, higher lung volumes and more non-scheduled medical visits.
Hemostatic Effect of Tranexamic Acid on the Zhuang Nationality Patients with Chronic Kidney Disease in the Total Hip Arthroplasty
Authors: Huang YU , Huang Xiao , Li Fulin , Huang Wenwen , Yin Dong 
Published: April 2020

Abstract
Purpose The hemostatic effect of Tranexamic Acid (TXA) is analyzed in total hip total hip arthroplasty (THA) operated on chronic kidney disease (CKD) patients in Zhuang nationality. Methods A review of 53 Zhuang nationality patients with CKD who underwent unilateral total hip replacement at the People's Hospital of Guangxi Zhuang Autonomous Region from December 2012 to December 2019. They were divided into two groups: 28 patients in the TXA group and 25 patients in the non-TXA group. Nine aspects of comparison are operation time, blood loss during operation, postoperative drainage, changes of hemoglobin content before and after operation, prothrombin time before and after operation, recessive blood loss during operation, the number of patients with blood transfusion and that of thrombosis one month after operation. Results Two groups of CKD patients Compared, there was no statistically significant difference (p> 0.05) in the following aspects, namely, preoperative hemoglobin, preoperative and postoperative prothrombin time, preoperative and postoperative creatinine, preoperative and postoperative blood urea nitroge, while in the aspects of immediate postoperative hemoglobin, 24-hour postoperative hemoglobin, intraoperative bleeding, postoperative drainage and 24-hour occult blood loss, the number of patients with blood transfusion (4 in TXA group and 10 in non-TXA group), there was statistically significant difference (p< 0.05). Deep venous thrombosis of lower extremities was found in both groups of CKD patients after one month. No cases of complications or death were reported in the included patients. Conclusions In the THA, the use of TXA on CKD patients in Zhuang nationality can reduce dominant and recessive blood loss and decrease the incidence of lower extremity deep vein embolism.
Process evaluation of the implementation of a parenting programme for Somali-born parents living in Sweden
Authors: Osman Fatumo , Schön Ulla-Karin , Klingberg-Allvin Marie , Flacking Renée , Tistad Malin 
Published: April 2020

Abstract
Background: Forced migration has been shown to have a negative impact on family dynamics, parenting and the parent-child relationship. Parental support programmes aim to strengthen family functioning, the parent-child relationship and promote the mental health of children and parents. However, there is a lack of knowledge in how parenting support programmes can be implemented for newly arrived immigrant parents. This study therefore aimed to increase knowledge about which strategies could be useful to implement a parenting support programme for immigrant parents from Somalia with special focus on how to reach and retain the target group. Methods: The study was an explorative study with focus on the process initiated by the implementation strategy. Both qualitative and quantitative data were used. Data were collected through focus group discussions, a questionnaire, attendance lists, field and reflection notes, and observations of the sessions. The data were then analysed through inductive and deductive analysis. Results: The findings showed that of the 60 parents who were invited to the parenting programme, 58 participated in the sessions. This process evaluation emphasises the importance of considering contextual factors such as building trust and involving the community when implementing parenting programmes through social services. The implementation strategies employed in the programme facilitated the engagement and retention of the parents in the programme. Group leaders delivered the intervention according to the manual. Parents were satisfied with the programme and reported having confidence in seeking support from social services. Conclusions: This study not only illustrates how a parenting support programme can be implemented for Somali-born parents but also provides guidance on how to engage and attract immigrant parents to participate in parenting support programmes.
Development of “Advancing People of Color in Clinical Trials Now!”: Web-Based Randomized Controlled Trial Protocol
Authors: Chung Alicia , Seixas Azizi , Williams Natasha , Senathirajah Yalini , Robbins Rebecca , Newsome Garcia Valerie , Ravenell Joseph , Jean-Louis Girardin 
Published: April 2020

BackgroundParticipation in clinical trials among people of color remains low, compared with white subjects. This protocol describes the development of “Advancing People of Color in Clinical Trials Now!” (ACT Now!), a culturally tailored website designed to influence clinical trial decision making among people of color.ObjectiveThis cluster randomized study aims to test the efficacy of a culturally tailored website to increase literacy, self-efficacy, and willingness to enroll in clinical trials among people of color.MethodsACT Now! is a randomized trial including 2 groups: (1) intervention group (n=50) with access to the culturally tailored website and (2) control group (n=50) exposed to a standard clinical recruitment website. Clinical trial literacy and willingness to enroll in a clinical trial will be measured before and after exposure to the website corresponding to their assigned group (intervention or control). Surveys will be conducted at baseline and during the 1-month postintervention and 3-month follow-up. Website architecture and wireframing will be informed by the literature and experts in the field. Statistical analysis will be conducted using a two-tailed t test, with 80% power, at .05 alpha level, to increase clinical trial literacy, self-efficacy, and willingness to enroll in clinical trials 3 months post intervention.ResultsWe will design a culturally tailored website that will provide leverage for community stakeholders to influence clinical trial literacy, self-efficacy, and willingness to enroll in clinical trials among racial and ethnic groups. ACT Now! applies a community-based participatory research approach through the use of a community steering committee (CSC). The CSC provides input during the research study conception, development, implementation, and enrollment. CSC relationships help foster trust among communities of color. ACT Now! has the potential to fill a gap in clinical trial enrollment among people of color through an accessible web-based website. This study was funded in July 2017 and obtained institutional review board approval in spring 2017. As of December 2019, we had enrolled 100 participants. Data analyses are expected to be completed by June 2020, and expected results are to be published in fall 2020.ConclusionsACT Now! has the potential to fill an important gap in clinical trial enrollment among people of color through an accessible web-based website.Trial RegistrationClinicalTrials.gov NCT03243071; https://clinicaltrials.gov/ct2/show/NCT00102401International Registered Report Identifier (IRRID)DERR1-10.2196/17589
COMPLEXIDADES PARA A APLICAÇÃO DOS ASPECTOS NORMATIVOS PARA A GESTÃO DE RECURSOS HÍDRICOS NO BRASIL
Authors: De Souza Frank Pavan , Pertel Mônica 
Published: April 2020

Nos últimos tempos, têm se percebido cada vez mais o consumo de água em processos produtivos e também nas áreas de saneamento. Seja para o consumo humano ou para as atividades industriais, a água é um recurso natural de extrema importância para manter a vida no planeta. O uso exacerbado desse recurso pode torná-lo escasso. Neste sentido, o objetivo dessa pesquisa foi analisar as complexidades para a aplicação dos aspectos normativos para a gestão de recursos hídricos no Brasil. Para o desenvolvimento da pesquisa foram verificadas as principais legislações federais associadas à gestão de recursos hídricos no Brasil (Lei 9.433/1997 e Código de Águas de 1934), bem como autores especialistas no tema abordado. O método adotado foi o dedutivo e a pesquisa classifica-se como bibliográfica. Por meio de plataformas científicas digitais, livros, teses, dissertações, foi realizado um levantamento de informações técnicas e jurídicas relacionadas à gestão de recursos hídricos. Ao final, pode-se concluir que no Brasil, existe um emaranhado de leis e normas aplicáveis a gestão dos recursos hídricos. Tais aspectos jurídicos, se aplicados de forma coesa e coletiva, podem contribuir com a gestão, melhor distribuição e manutenção da água em quantidade e qualidade disponíveis para todos os usuários.
Slaying the Leviathan: Critical Jurisprudence and The Treaty of Waitangi
Authors: Upston-Hooper K 
Published: April 2020

This article considers the perspectives of four contributors to the current discourse on the Treaty of Waitangi: Professor Jane Kelsey, Dr Paul McHugh, Professor F M Brookfield and Moana Jackson. The jurisprudential underpinnings of each authors arguments are examined. The article focuses on the degree to which two new forms of jurisprudential thought, Critical Legal Studies and Critical Race Theory, have informed the Treaty discourse. The article concludes that, although such critical jurisprudence has yet to permeate New Zealand jurisprudence in any meaningful way, Critical Race Theory could help transform post-settler legal thinking. This article was awarded the Quentin-Baxter LLM prize in Public and International Law in 1997.
Delivering search skills training for healthcare staff in England
Authors: Lewis Sarah , Pratchett Tracey 
Published: April 2020

This study evaluated a national collaborative project to develop generic, freely available e-learning modules on literature search skills for the healthcare workforce in NHS England. Feedback data was drawn from usage reports, an online survey embedded within each module and a separate online survey nationally distributed to health-related library staff. The modules evaluated positively; learners found them useful, they impacted on learning and confirmed or increased knowledge. Only 3% reported that the modules made no difference to their literature search skills. There was also evidence that some libraries were using the modules as part of their local training. The study suggests that although there are challenges in trying to develop a one size fits all approach to e-learning, collaborating with potential end users and trainers can help to maximise its usefulness.