bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Resveratrol dose and Duration of Treatment on Blood Pressure in Patients with Cardiovascular Disorders: A Systematic Review
Authors: Mashhadi Fahimeh D. , Salari Roshanak , Ghorbanzadeh HamidReza 
Published: November 2019

Objective:Hypertension is an important risk factor that causes many deaths in the world every year. Researchers continue to undertake studies to find an effective drug for reducing blood pressure. One of the phytochemicals that recently attracted the attention of researchers is resveratrol-polyphenol, found in grapes. The purpose of this systematic review is to investigate the effect of resveratrol as a cardioprotective agent effective in reducing hypertension in patients with hypertension.Methods:Studies and clinical articles from databases Scopus, Pubmed, Ovid and Cochrane have been collected until September 2017; the keywords are Blood Pressure, Hypertension, Hypertensive, Cardiovascular, and Resveratrol.Results:Data from five studies with a total of 229 hypertensive and pre-hypertensive patients (men and women) showed that resveratrol plays an important role in reducing blood pressure.Conclusion:Resveratrol appears to have anti-hypertensive effects, depending on the dose and duration of treatment. Researchers attribute one of the important blood pressure reducing mechanisms of resveratrol to increasing levels of NO. Based on the results of this systematic review, it is suggested that more clinical studies be conducted to find the appropriate dose and duration of treatment.
NMR: From Molecular Mechanism to its Application in Medical Care
Authors: Zhang Zhenhong , Meng Xiaohong , Cui Wei , Ahmad Syed S. , Kamal Mohammad A. , Zhang Jinguo 
Published: November 2019

Background:
Nuclear Magnetic Resonance (NMR) spectroscopy is a systematic science
strategy utilized in pharmaceutical research, development, quality control, and research to decide
the content and purity of a sample as well as its sub-atomic structure. There are several parameters
working for better execution of NMR which can include chemical shifts, spin multiplicity, pH dependence,
heteronuclear and homonuclear covalent network, and the atomic overhauser impact.
NMR imaging offers an extensive scope of potential outcomes for the portrayal of skeletal muscle
structure, function and metabolism. 1H additionally has the most noteworthy NMR affectability of
any nucleus. The principle of NMR depends on the spins of atomic nuclei. The magnetic estimations
rely on an unpaired electron, while NMR estimates attractive impact brought about by the
turn of protons and neutrons. The nucleons have intrinsic angular momenta or spins, which is considered
as basic magnet.

Conclusion:
The presence of atomic attraction was uncovered in the hyperfine structure of spectral
lines. If the nucleus magnetic moment is put in the magnetic field, the phenomenon of space quantization
can be observed and each allowed direction will have a marginally unique energy level. Invitro,
high-resolution NMR spectroscopy helps to assess tumor metabolism by the investigation of
body liquids like urine, blood and removed tissue specimens. In-cell NMR is a powerful technique
to assess strong compounds in medication improvement to spare exploratory expenses.
Apigenin, A Plant Flavone Playing Noble Roles in Cancer Prevention Via Modulation of Key Cell Signaling Networks
Authors: Singh Deepti , Khan Mohammad A. , Siddique Hifzur R. 
Published: November 2019

Background:
Cancer is a global health problem and the continuous rise in incidence and
mortality due to cancer carries a real economic burden to all countries. Accumulation of genetic mutation,
exposure of environmental carcinogens and food habits due to change in lifestyles are the key
reasons for cancer. Targeting cancer cells, we need a multitargeting molecule with low/no toxicity.

Objective :
To review the current update of the research status of chemopreventive/therapeutic molecule,
Apigenin.

Methods:
Compare the results of the published articles and granted patents on this compound. We also
discuss the pros and cons of the present research and future direction.

Results:
Cancer cells have characteristic alterations and dysregulation of various cell signaling pathways
that control cell homeostasis, proliferation, motility, and survival in normal cells. Natural flavonoids
are the compounds well known for their anti-inflammatory, anti-oxidant, and anti-cancerous
properties. Apigenin, along with several other physiological effects, has a very low intrinsic toxicity
and striking effects on the proliferation of cancer cells. Interestingly, this multitargeting molecule is
getting wide acceptance among researchers. It is evident from the recent patents filed in this compound.
At present, three patents have been granted only on the anticancer properties of apigenin.

Conclusion:
This mini-review will explain the present research status of apigenin and will further
shine some light on how apigenin performs its anti-cancerous actions by interfering with the key cellsignaling
pathways.
The Molecular and Enzyme Kinetic Basis for Altered Activity of Three Cytochrome P450 2C19 Variants Found in the Chinese Population
Authors: Dong Amelia Nathania , Ahemad Nafees , Pan Yan , Palanisamy Uma Devi , Yiap Beow Chin , Ong Chin Eng 
Published: November 2019

Background:There is a large inter-individual variation in cytochrome P450 2C19 (CYP2C19) activity. The variability can be caused by the genetic polymorphism of CYP2C19 gene. This study aimed to investigate the molecular and kinetics basis for activity changes in three alleles including CYP2C19*23, CYP2C19*24 and CYP2C19*25found in the Chinese population.Methods:The three variants expressed by bacteria were investigated using substrate (omeprazole and 3- cyano-7-ethoxycoumarin[CEC]) and inhibitor (ketoconazole, fluoxetine, sertraline and loratadine) probes in enzyme assays along with molecular docking.Results:All alleles exhibited very low enzyme activity and affinity towards omeprazole and CEC (6.1% or less in intrinsic clearance). The inhibition studies with the four inhibitors, however, suggested that mutations in different variants have a tendency to cause enhanced binding (reduced IC50 values). The enhanced binding could partially be explained by the lower polar solvent accessible surface area of the inhibitors relative to the substrates. Molecular docking indicated that G91R, R335Q and F448L, the unique mutations in the alleles, have caused slight alteration in the substrate access channel morphology and a more compact active site cavity hence affecting ligand access and binding. It is likely that these structural alterations in CYP2C19 proteins have caused ligand-specific alteration in catalytic and inhibitory specificities as observed in the in vitro assays.Conclusion:This study indicates that CYP2C19 variant selectivity for ligands was not solely governed by mutation-induced modifications in the active site architecture, but the intrinsic properties of the probe compounds also played a vital role.
Punica granatum L. Inhibits the Growth of Microorganisms Associated with Bovine Mastitis
Authors: Freitas Tauana F. , Marques Fernanda M. , Kuster Ricardo M. , Salles João B. , Victório Cristiane P. , de Assis Maria Cristina 
Published: November 2019

Background:
The current research aimed to explore secondary metabolites and antibacterial
activity against bacterial agents associated with bovine mastitis from extracts prepared from the
peel of fruits of Punica granatum L.. Mastitis is an inflammation in the mammary gland mainly due
to infection of bacteria and can be presented clinically or subclinically. The infectious bovine mastitis
disease is associated with the reduction and changes in the composition of the milk, as well as in
the early disposal of the animal.

Objective:
We describe the bactericidal activity of ethanolic extracts of the fruit peel of P. granatum,
against etiological agents of bovine mastitis (Escherichia coli, Staphylococcus aureus and Streptococcus
agalactiae).

Method:
The bactericidal activity was evaluated according to the standards of the European Committee
for Antimicrobial Susceptibility Testing and by the broth microdilution methodology according
to the standards of the Clinical and Laboratory Standards Institute. The fruit peel extracts of P.
granatum were prepared with ethanol solvent (90%).

Results:
The best results of total inhibition of bacterial growth of the three strains tested were obtained
with the concentrations of 75mg/mL of the extract after 1 and 3 hours of treatment. Cell
membrane integrity analysis by flow cytometry showed that 1 h of contact there was loss of integrity
of the wall and cell membranes.

Conclusion:
We can suggest that the ethanolic extract of the fruit peel of P. granatum can be an important
natural coadjutant compound in the treatment of mastitis as well as being used in the formulation
of sanitizers.
Comparative Study on the Antibacterial Properties of Nanoemulsion of Zataria multiflora Essential Oil Fortified with Cinnamaldehyde Against Common Foodborne Pathogens
Authors: Soufi Shahnaz , Aminzare Majid , Azar Hassan Hassanzad , Kamali Koorosh 
Published: November 2019

Background:
Nowadays, the application of several and natural preservatives in small
quantity is a more preferred approach. In this regard, one of the effective methods is the formation of
nanoemulsion of essential oils.

Objective:
The objective of this study was to compare the in vitro antibacterial activities of cinnamaldehyde
(CIN) and Zataria multiflora essential oil in conventional (ZEO), nanoemulsion
(NZEO) and fortified nanoemulsion (NZEOC) forms against common foodborne pathogens.

Methods:
Firstly, the Zataria multiflora essential oil was analyzed by GC-MS. The nanoemulsion of
Z. multiflora essential oil was then prepared alone and fortified with cinnamaldehyde. Finally, their
antimicrobial activity against Listeria monocytogenes, Staphylococcus aureus, Salmonella enteritidis
and Escherichia coli was evaluated.

Results:
Based on the results, carvacrol (36.62%) was found to be the most important compound of
essential oil. In disc diffusion and micro-dilution methods, the addition of CIN to ZEO during
nanoemulsion formation (NZEOC) showed more antibacterial activity when compared to the individual
addition of NZEO and CIN (NZEO+CIN). However, according to the vapor phase diffusion
method, nano-treatments exhibited less inhibitory effects than the other treatments.

Conclusion:
It can be concluded that the fortification of essential oils with their derived pure compounds
during nanoemulsion formation, can be used as a suitable alternative to chemical antibacterial
compounds in the food industry.
Usability of the Turkish Translation of the Dutch Talking Touch Screen Questionnaire for Physical Therapy Patients With a Turkish Background: Qualitative Study
Authors: Welbie Marlies , Wittink Harriet , Bozkurt Sahin , Coban Tugba , Devillé Walter LJM 
Published: November 2019

Background
The Turkish translation of the Dutch Talking Touch Screen Questionnaire (TTSQ) has been developed to help physical therapy patients with a Turkish background in the Netherlands to autonomously elucidate their health problems and impairments and set treatment goals, regardless of their level of health literacy.

Objective
The aim of this study was to evaluate the usability of the Turkish TTSQ for physical therapy patients with a Turkish background with diverse levels of health literacy and experience in using mobile technology.

Methods
The qualitative Three-Step Test-Interview method was carried out to gain insight into the usability of the Turkish TTSQ. A total of 10 physical therapy patients participated. The interview data were analyzed using a thematic content analysis approach aimed at determining the accuracy and completeness with which participants completed the questionnaire (effectiveness), the time it took participants to complete the questionnaire (efficiency), and the extent to which the participants were satisfied with the ease of use of the questionnaire (satisfaction). The problems encountered by the participants in this study were given a severity rating, which was used to provide a rough estimate of the need for additional usability improvements.

Results
No participant in this study was able to complete the questionnaire without encountering at least one usability problem. A total of 17 different kinds of problems were found. On the basis of their severity score, 3 problems that should be addressed during future development of the tool were “Not using the navigation function of the photo gallery in Question 4 causing the participant to not see all presented response items;” “Touching the text underneath a photo in Question 4 to select an activity instead of touching the photo itself, causing the activity not to be selected;” and “Pushing too hard or tapping too softly on the touch screen causing the touch screen to not respond.” The data on efficiency within this study were not valid and are, therefore, not reported in this study. No participant was completely satisfied or dissatisfied with the overall ease of use of the Turkish TTSQ. Two participants with no prior experience of using tablet computers felt that, regardless of what kinds of improvement might be made, it would just be too difficult for them to learn to work with the device.

Conclusions
As with the Dutch TTSQ, the Turkish TTSQ needs improvement before it can be released. The results of this study confirm the conclusion of the Dutch TTSQ study that participants with low levels of education and little experience in using mobile technology are less able to operate the TTSQ effectively. Using a Dutch speaking interviewer and Turkish interpreter has had a negative effect on data collection in this study.
Awareness and Opinions of Research Professionals on India's New Drug and Clinical Trials Regulations: Protocol for a Cross-Sectional Web-Based Survey Study
Authors: Vennu Vishal , Dahiya Saurabh 
Published: November 2019

Background
Although several studies have been conducted and several articles have been published on India's new clinical trial regulations, very few have examined the views of investigators and ethics board members regarding modifications to the previous regulations. Overall, they have neglected to find out the opinions of other relevant professionals, such as research assistants, coordinators, associates, and managers. To our knowledge, no study has yet investigated the awareness and opinions of Indian research professionals on the new 2019 regulations.

Objective
This study aims to describe the awareness and opinions of Indian research professionals on the new drug and clinical trial regulations.

Methods
In this cross-sectional, Web-based study, we will conduct an open survey for various Indian research professionals. These professionals will be selected randomly using multiple sources. The survey questionnaires, which have already been validated, were developed using the form function in Google docs. A Web link was generated for participants to take the survey. Descriptive statistics will be shown as means and standard deviations for constant variables, whereas certain variables will instead be shown as numbers and percentages.

Results
The survey was opened in July 2019. Enrollment has already started and will be completed in three months. The results calculations are expected to begin in October 2019.

Conclusions
The results of the survey are expected to represent the views of research professionals on the new regulations that will support the development of clinical research and the pharmaceutical industry in India. These regulations are expected to help advance clinical trials, help with the approval of new drugs, and enhance ethical norms in the country.

International Registered Report Identifier (IRRID)
PRR1-10.2196/14744
Financiarización y Desarrollo: ¿Cómo pueden ponerse al día las economías emergentes?
Authors: Guizzo Danielle , Strachman Eduardo , Dalto Fabiano , Feijo Carmem 
Published: November 2019

<p>Las influencias de la financiarización sobre las economías emergentes han llamado mucho la atención sobre si estas naciones pueden o no superar sus limitaciones y promover niveles de desarrollo satisfactorios. Sin embargo, las posibilidades de superar el dominio financiero merecen mayor atención sobre lo que concierne a sus causas estructurales y las políticas alternativas. Este artículo tiene dos objetivos: a) formaliza tres características clave detrás de la financiarización de las economías en desarrollo, enfocándose en algunos elementos clave que diferencian la financiarización en las economías desarrolladas y emergentes: el comportamiento de la tasa de interés; la volatilidad del tipo de cambio y el dominio de la balanza de pagos. b) analiza algunas estrategias para que estos países superen los efectos de la financiarización en base a la hipótesis de aumentar el espacio de políticas, lo que permite a estas economías mantener la autonomía en sus políticas macroeconómicas y llevar a cabo políticas internas en un escenario integrado.</p><div><br /><div><p> </p></div></div>
Financiarización, empleo y relaciones laborales en la industria automotriz en México
Authors: Marcial Flores Aurora 
Published: November 2019

<p>Aquí se abordan las discusiones teórico-conceptuales de la corriente heterodoxa para caracterizar el fenómeno de la financiarización en la industria automotriz. La revisión orienta la relocalización de los motivos, objetivos y necesidades de las corporaciones automotrices para desplazarlos del ámbito productivo al ámbito financiero. También permite argumentar que las condiciones actuales del empleo y del sistema de relaciones laborales del segmento productivo automotriz en México son consecuencia del despliegue del fenómeno de la financiarización conducido por las corporaciones automotrices en el ámbito global. Se emplea el análisis empírico para mostrar que las estrategias corporativas son tendientes a incrementar el valor del accionista, esto es, a incrementar las ganancias de capital en los mercados financieros, a incrementar el pago de dividendos y el volumen de los rendimientos. Las consecuencias de lo anterior es el incremento de la volatilidad y la fragilidad del sector financiero, y la intensificación del cambio en las relaciones de poder entre el capital y el trabajo; en términos del argumento teórico, en favor del capital y en detrimento de la clase trabajadora.</p><p><strong> </strong> </p>
The assessment of power influence of discharge flow from surges under conditions of hydrologically hazardous natural phenomena
Authors: Solovyev Alexander A. , Solovyev Dmitry A. , Shilova Liubov A. 
Published: November 2019

Introduction. The analysis of studies on waves of translation and their dynamic effects on water infrastructure facilities indicates the incompleteness of accounting the dispersion component of wave motions in discharge flows. Existing analysis methods for the surge parameters with the dependence of the propagation velocity and wave pressure on the wavelength should be only considered as a rough approximation of the role of dispersion processes accompanying the surge propagation in river flows. The purpose of the research is to increase the accuracy of reliability analyses for equipment and auxiliary mechanisms of hydraulic structures and water facilities in the context of the growth of hydrologically hazardous natural phenomena in the form of surges.
Materials and methods. The article used an analytical method for calculating the wave motion parameters. It is based on determining the conditions for synchronism of jumps and discontinuities in the parameters of the medium state when passing through front surfaces. An option was suggested for using the frontal characteristics method for integrating equations of unsteady currents in open flows. The paper presented a scheme for solving the differential equations of unsteady motions and continuity of flows in river streams with surges in the presence of resistance forces.
Results. Analytical design relations were obtained for the velocity and power effects of surges with dispersion dependence on wavelength. An analysis of the obtained solutions is carried out by illustrating the dynamic effects of wave dispersion on water infrastructure facilities.
Conclusions. The suggested method of the more accurate analysis for the force impact of the discharge flow from surges on the structural elements of hydro-economic and water-transport facilities can be used to determine the reliability of hydraulic structures and water-transport facilities. The obtained analysis relations for determining the kinematic and dynamic characteristics of the dispersion of the surges are advisably recommended to supplement the existing regulatory documents on hydraulic engineering.
Akomodasi Pesantren Terhadap Kebijakan Pendidikan Nasional
Authors: Burga Muhammad Alqadri , Arsyad Azhar , Damopolii Muljono , Marjuni Andi 
Published: November 2019

This research aims to analyze the dynamics of Pondok Pesantren DDI Mangkoso in accommodating national education policies. The method of this research is qualitative with a phenomenological approach whose data is collected through observation, interviews, and documentation. The results of the research indicate that the status of Pondok Pesantren DDI Mangkoso as a traditional Islamic education institution still existed despite carrying out modern developments by maintaining five roles, namely: the place of transmission of classical Islamic sciences, daâ€™wah institutions, preserving Islamic traditions, the center of reproduction of scholars, and place of community service and development. Changes in the position of pesantren in national education policy during the period 1989-2018 have implications for the education policy of Pondok Pesantren DDI Mangkoso whose dynamics are divided into three stages, namely: institutional transformation, integration of curriculum, and application of a culture-basedÂ inclusive paradigm. The form of accommodation for the national education policy by Pondok Pesantren DDI Mangkoso is the opening of formal education institutions at all levels of education. Various obstacles in the accommodation are the struggle of organizational culture and structure, limited resources, and lack of community participation.