bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Vivo Evaluation of Painful Symptomatology after Endodontic Treatment Performed Using Two Different Irrigation Needle Insertion Depths
Authors: Tavares Sarah Gutierrez , Fontana Carlos Eduardo , Martin Alexandre Sigrist De , Pinheiro Sérgio Luiz , Pelegrine Rina Andrea , Rocha Daniel Guimarães Pedro 
Published: May 2020

Abstract
Objective The main purpose of this study was to evaluate pain symptoms in patients after endodontic treatment performed in a single session in teeth with vitality or pulp necrosis, comparing two depths of insertion of the NaviTip irrigation needle.
Materials and Methods One-hundred upper uniradicular teeth were selected and divided into four groups (n = 25), namely Bio group 1 (live pulp/1 mm from the foramen), Bio group 3 (live pulp/3 mm from the foramen), Necro group 1 (pulp necrosis/1 mm from the foramen), and Necro group 3 (pulp necrosis/3 mm from the foramen). All canals were instrumented with Wave One Gold System. Irrigation was performed using 2.5% NaOCl. The teeth were filled using the single-cone technique with AH Plus sealer using a McSpadden compactor. After treatment, patients answered a questionnaire with a visual analog scale scored from 0 to 10 at 1, 3, and 7 days after treatment.
Statistical Analysis Data were analyzed using Mann–Whitney U, Wilcoxon, and Friedman tests.
Results There was a decrease in average pain levels at the three time points for both vital and necrotic teeth (p < 0.05). There were no significant differences in postoperative pain levels comparing needle depth, or vitality and pulp necrosis (p > 0.05). The percentage of mild pain increased over time and moderate pain decreased, regardless of pulp condition. There was no incidence of acute pain at any time.
Conclusions Post-treatment endodontic pain levels in upper uniradicular teeth with or without pulp vitality resulted in similar pain scores, regardless of the depth of insertion of the irrigation needle in relation to the apical foramen.
A Case of Neonatal Diabetes Mellitus Due to INS Gene Mutation with Maternal Mosaicism and Atypical Presentation
Authors: Vyas Varuna , K. Deepthi , Singh Kuldeep 
Published: May 2020

AbstractNeonatal diabetes mellitus is a single gene defect that results in diabetes mellitus in the first 6 months of life. We report a child who was diagnosed to be hyperglycemic at 13 months of life and assumed to have type 1 diabetes mellitus and started on insulin. The child came to us at 2 and 1/2 years of age. He had exceptionally good blood glucose control. His history revealed that he was symptomatic with a voracious appetite and poor weight gain since the second half of infancy. Genetic testing revealed a heterozygous mutation of the INS gene (the gene that codes for insulin). The condition has autosomal dominant inheritance. Testing the parents revealed that the mother had 7.8% mosaicism for this variant in her lymphocyte DNA. Though this did not alter the management of the patient, it did help in counseling the parents regarding risk of recurrence in future pregnancies.
Neurological Nuance: Sporadic Burkitt's Lymphoma Presenting with Guillain–Barre Syndrome
Authors: Bouattour Nadia , Kamoun Fatma , Charfi Slim , Nsir Siham Ben , Bouchaala Wafa , Boudawara Tahya , Triki Chahnez 
Published: May 2020

AbstractBurkitt's lymphoma (BL) is a high-grade mature B cell neoplasm. Primary lymphoma of the central nervous system (CNS) is very rare. In contrast, BL can be localized in any part of the body and may spread to the CNS. Peripheral nervous system impairment caused by BL has been thoroughly described. However, Guillain–Barre syndrome (GBS) does not commonly appear as an initial manifestation of BL. We presented the case of a young child with sporadic BL with neuromeningeal involvement and spinal cord compression whose first clinical manifestation was the appearance of GBS. Lymphoma should be taken into account, especially in children presenting with the clinical features of acute polyradiculoneuropathy.
A Novel c.968C > T homozygous Mutation in the Polynucleotide Kinase 3′ − Phosphatase Gene Related to the Syndrome of Microcephaly, Seizures, and Developmental Delay
Authors: Marcilla Vázquez Carlos , Carrascosa Romero María del Carmen , Martínez Gutiérrez Andrés , Baquero Cano María , Alfaro Ponce Blanca , Dabad Moreno María Jesús 
Published: May 2020

AbstractMicrocephaly is defined by a head circumference that is at least two standard deviations below the mean for age and sex of the general population in a specific race. Primary microcephaly may occur as an isolated inborn error, which may damage to the central nervous system or as part of the congenital abnormalities associated with genetic syndrome, affecting multiple organ systems. One of the syndromic forms consists of microcephaly, seizures, and developmental delay caused by biallelic mutations in the gene that encode polynucleotide kinase 3′ − phosphatase protein (PNKP). In this article, we reported a newborn male who presented with microcephaly, severe developmental delay, and early-onset refractories seizures, caused by a novel homozygous mutation of the PNKP gene.
Nonlinear hydrodynamic instability and turbulence in pulsatile flow
Authors: Xu Duo , Varshney Atul , Ma Xingyu , Song Baofang , Riedl Michael , Avila Marc , Hof Björn 
Published: May 2020

Significance
The inner lining of blood vessels, the endothelium, is shear sensitive. Fluctuating shear stresses and disordered flow are responsible for cellular dysfunction, leading to the development of atherosclerotic lesions. We here identify a nonlinear hydrodynamic instability that gives rise to disordered motion in the parameter range of cardiovascular flow. During flow deceleration small geometrical imperfections trigger a helical vortex pattern that subsequently breaks down into bursts of turbulence. The resulting fluctuating shear stress level drops abruptly during the acceleration where flow relaminarization sets in. The observed instability occurs at considerably lower flowrates than either the linear instability or the classic route to turbulence. Our study shows that disordered motion is more common in pulsatile/cardiovascular flows than previous stability considerations suggest.
Evaluation of plant sources for antiinfective lead compound discovery by correlating phylogenetic, spatial, and bioactivity data
Authors: Holzmeyer Laura , Hartig Anne-Kathrin , Franke Katrin , Brandt Wolfgang , Muellner-Riehl Alexandra N. , Wessjohann Ludger A. , Schnitzler Jan 
Published: May 2020

Significance
The continued high rates of using antibiotics in healthcare and livestock, without sufficient new compounds reaching the market, has led to a dramatic increase in antimicrobial resistance, with multidrug-resistant bacteria emerging as a major public health threat worldwide. Because the vast majority of antiinfectives are natural products or have originated from them, we assessed the predictive power of plant molecular phylogenies and species distribution modeling in the search for clades and areas which promise to provide a higher probability of delivering new antiinfective compound leads. Our approach enables taxonomically and spatially targeted bioprospecting and supports the battle against the global antimicrobial crisis.
Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression of soluble epoxide hydrolase
Authors: Pu Yaoyu , Yang Jun , Chang Lijia , Qu Youge , Wang Siming , Zhang Kai , Xiong Zhongwei , Zhang Jiancheng , Tan Yunfei , Wang Xingming , Fujita Yuko , Ishima Tamaki , Wan Debin , Hwang Sung Hee , Hammock Bruce D. , Hashimoto Kenji 
Published: May 2020

Significance
Maternal exposure to high levels of the herbicide glyphosate may increase the risk for autism spectrum disorder (ASD) in offspring; however, the underlying mechanisms remain largely unknown. Maternal glyphosate exposure during pregnancy and lactation caused ASD-like behavioral abnormalities and abnormal composition of gut microbiota in murine male offspring. Soluble epoxide hydrolase (sEH) in the brain of offspring after maternal glyphosate exposure was higher than controls. Treatment with an sEH inhibitor from pregnancy to weaning prevented the onset of ASD-like behavioral abnormalities in offspring after maternal glyphosate exposure. The glyphosate exposures used here exceed any reasonable dietary, environmental, or occupational exposure, but they indicate that increased sEH plays a role in ASD-like behaviors in offspring.
Multiple epithelia are required to develop teeth deep inside the pharynx
Authors: Oralová Veronika , Rosa Joana Teixeira , Larionova Daria , Witten P. Eckhard , Huysseune Ann 
Published: May 2020

Significance
Many vertebrates possess teeth deep in the pharynx. While teeth are known to derive from odontodes (skin denticles), it is unknown if an external epithelium is still required to produce a pharyngeal tooth, such as for odontode formation. Here, we show that the epithelial enamel organ of pharyngeal teeth in zebrafish is formed from endoderm, i.e. the internal germ layer. However, teeth develop 1) only when this endoderm becomes covered by a layer of cells with features of a periderm, i.e., the outer epithelial covering of the embryo; and 2) only when the endoderm has physically contacted the skin at the prospective gill slits. Thus, multiple epithelia are engaged in tooth formation, whether oral (mammals) or pharyngeal (teleosts).
Linguistic disadvantage before the law
Authors: Ng Eva N.S. 
Published: May 2020

Abstract
This chapter builds on my research into the
interactional dynamics in the unique bilingual Hong Kong courtroom,
where interpretation is, by and large, provided for the linguistic
majority. Drawing on authentic courtroom data, this study
demonstrates how non-native English speaking (NNES) witnesses, by
waiving their right to an interpreter, can be disadvantaged due to
their linguistic incompetence. It explores how NNES witnesses are
further disadvantaged in the antagonistic process of
cross-examination, as counsel frequently violate the Gricean
Cooperative Principle. It also discusses how this might compromise
the access of other NNES court participants such as jurors to the
trial in its entirety in the special context of the Hong Kong
courtroom, and potentially impact the delivery of justice.
Exploring role expectations of healthcare interpreters in New
Zealand
Authors: Crezee Ineke H.M. , Jülich Shirley 
Published: May 2020

Abstract
Reports from practising healthcare interpreters
in New Zealand suggest that they and the health professionals they
work with often have conflicting understandings of the healthcare
interpreter role. This chapter reports on the findings of a series
of surveys among health professionals and healthcare interpreters in
New Zealand designed to investigate these differences. Separate
surveys were posted for health professionals and healthcare
interpreters respectively and answers as to role expectations were
compared. The survey findings showed that health professionals’ role
expectations conflicted with the code of ethics followed by New
Zealand trained interpreters in some key areas. It is hoped that
these findings may provide insights which can be addressed in
interpreter education or in professional development sessions for
health professionals working with interpreters.
Overcoming language barriers in the Spanish healthcare
context
Authors: Valero Garcés Carmen 
Published: May 2020

Abstract
The progression towards multicultural societies
impacts on the quality of communication between professionals and
their clients. This chapter focuses on the analysis of communication
in a specific setting, namely the Spanish healthcare system, and
concludes that language is a significant barrier to optimal patient
outcomes. An analysis is given of one of the approaches used to
mitigate the language barriers between medical professional and
patient: INTER+MED, a project which aimed to design training for,
coordinate and monitor a team of interlingual and intercultural
mediators working in health centres in the Madrid region of central
Spain. An analysis of the data obtained from surveys of patients and
professionals is presented, followed by a discussion of themes which
emerged from the interpreter observation forms pertaining to
specific ethnic groups.
Metaphor in multimodal creativity
Authors: Okonski Lacey , Gibbs Raymond W. , Chen Elaine 
Published: May 2020

Abstract
This chapter describes the role that metaphor plays in multimodal creativity in several creative endeavors, specifically music, art, dance, and advertising. Many creative instances of metaphor performance rely on entrenched metaphorical concepts that get manifested in very specific, concrete ways in different artistic domains. Furthermore, although metaphorical thought and language are typically believed to map information from an embodied source domain into more abstract target domains, we argue that creative multimodal performance emerges from people’s very ordinary, yet still highly metaphorical, conceptualizations of mundane bodily experiences. We explore multimodal creativity not just from seeking metaphors as manifested in different domains (e.g., music, art, dance), but also from the ways people talk about creative expressions and understandings.
What makes an advert go viral?
Authors: Pérez-Sobrino Paula , Littlemore Jeannette 
Published: May 2020

Abstract
This chapter investigates the potential role played by the creative use of figurative operations, such as metaphor, metonymy, irony, hyperbole, and understatement, in the success of Internet videos. Irony and figurative language based on creative contrasts between contrasting scenarios were found to be strong predictors of popularity. This effect increased if the message was conveyed through a combination of words and images, rather than through the use of either mode in isolation. No effect was found for the positioning of figurative operations in the advertisement’s timeline. Our findings contribute to the wider marketing field by establishing figurative operations, in particular irony, as a potential determinant of a video’s success.
Disentangling metaphoric communication
Authors: Domínguez Martí 
Published: May 2020

Abstract
This work addresses the different processes involved in the genesis and evolution of metaphors. Studying mainly cartoons published after dramatic events, I show how, when facing a communication need due to a situation of media stress, metaphors are generated to promote news dissemination and comprehension. I propose that an efficient metaphor quickly transforms into a meme that effectively colonizes the communication ecosystem, thanks to the Internet and social networks platforms. In addition, I explain how metaphors can collaborate and evolve together, in a process I name metaphor symbiogenesis. The way these metaphors approach particularly complex and delicate issues has great communicative potential and can become an independent process in metaphor evolution.
Creative journeys
Authors: Williams Camus Julia T. 
Published: May 2020

Abstract
This chapter draws on the notion of creative recontextualization to explore how metastasis is recontextualized through metaphor in a bilingual English-Spanish corpus of press popularization articles on cancer. The quantitative and qualitative analysis revealed marked cross-cultural differences. Thus, while the English subcorpus presents the process with little metaphorical aid, the Spanish subcorpus displays a wider array of images involving movement. Nevertheless, the use of metaphor in both subcorpora generally involved a creative recontextualization of the source domains found in more specialized scientific genres for metastasis (invasion and colonization, dissemination and migration) through the ‘opening up’ of theory-constitutive metaphors. In addition, a particularly creative strategy was the personification of biological entities, which were vilified and portrayed as participating in delinquent activities.
Multimodal creativity in figurative use
Authors: Naciscione Anita 
Published: May 2020

Abstract
This chapter attempts to provide insights into actual language use in multimodal discourse. Observation and analysis focus on multimodal creative use of stylistic patterns: extended metaphor, metonymy, visual pun, allusion, hyperbole, personification. The study also brings out the role of semiotic elements and the significance of background information comprehension and interpretation of multimodal discourse.
My aim is to explore multimodality as a tool, applicable in creative figurative thought instantiations. Multimodal discourse reveals the capacity of the human brain to express figurative thought in various semiotic modes. As our brain is inherently multimodal, it is able to cognise figurative meaning in both verbal and non-verbal representation: visual, audial, body language, sound, color.
Biographical retrodiction for investigating the evolution of learner
agency and L2 writing development through study abroad experiences
Authors: Nitta Ryo 
Published: May 2020

Abstract
This chapter explores the complex and dynamic
interrelations between L2 writing development and the evolution of learner
agency by using biographical retrodiction. A series of
in-depth interviews was conducted with two expert learners before and after
a study abroad period and narratives of their English learner experiences
were constructed. The findings suggest that both expert learners changed
their attitudes towards L2 writing according to the progress of their
overall L2 proficiency and that learner agency recurrently emerged in the
classroom and study-abroad contexts. The findings also emphasize the
usefulness of biographical retrodiction for analyzing accounts constructed
from learners’ narratives and contribute to understanding how various
components within learners’ agentic systems interact to complement L2
writing development.
A critical appraisal of the CDST approach to investigating linguistic
complexity in L2 writing development
Authors: Bulté Bram , Housen Alex 
Published: May 2020

Abstract
This chapter aims to help the complex dynamic systems
theory (CDST) approach to second language acquisition reach its full
potential by critically appraising its current applications to complexity in
L2 writing development. To further this end, we first review five
representative empirical CDST-inspired studies on complexity in L2 writing.
Second, we contrastively analyze a dataset of beginning L2 writing
productions from both a “traditional” and a CDST perspective. Several issues
central to a CDST approach are discussed, including the link between CDST
concepts and research methods, the emphasis on variation and variability as
a window on and a driver of L2 development, the generalizability of
findings, anti-reductionism, and the treatment of measurement noise as
important information about L2 development. We identify challenges for
applying CDST concepts and methods to L2 (writing) development, illustrate
how researchers try to come to grips with these challenges, and offer
suggestions for addressing them.
Envisioning L2 writing development in CDST under a curricular
optic
Authors: Byrnes Heidi 
Published: May 2020

Abstract
The chapter presents an integrated proposal for viewing
CDST-inspired inquiry into L2 writing development under a curricular optic.
After establishing the need for an object theory of language that aligns
with the principles of complexity theory, it considers how the educational
setting itself, composing abilities and their development, and the agentive
L2 writer might be imagined within a complexity theory approach. On that
basis it posits that the educational construct of curriculum, interpreted as
a subsystem of the complex system of formal education, can provide an
environment for studying L2 writing development in an educationally
motivated, holistic, and dynamic way that interprets the L2 composer’s
evolving agency toward textual meaning-making in light of the structures,
processes, and affordances that hold in a particular educational setting.
The chapter concludes by considering broader theoretical, research, and
education-oriented implications of such a proposal.
Unpacking ‘simplex systems’
Authors: Fogal Gary G. 
Published: May 2020

Abstract
Following on Byrnes’ call (2018; this volume) to widen the scope of a complex
dynamic systems theory (CDST) view of L2 writing, this chapter explores
writing beyond the level of developmental processes. To do so, this work
operationalizes ‘simplex systems’ (van
Geert & Steenbeek, 2014) through an exploratory case study
that examines how stakeholders in an English-medium actuary science program
in a Thai university interpret the influence of different program-wide
variables on developing L2 writing. Data underscore how structures of the
program (e.g., the soft-assembly of orientations to time across constituent
groups) benefitted all stakeholders. The findings help move L2 writing,
CDST-related research in a new direction and demonstrate how exploring
simplex systems can impact how writing development is envisioned,
researched, and nurtured longitudinally through a curriculum.
Nitrogen and high oxygen-containing metal-free porous carbon nanosheets for supercapacitor and oxygen reduction reaction applications
Authors: Veeramani Vediyappan , Raghavi Govindan , Chen Shen-Ming , Madhu Rajesh , Sivakumar Mani , Tashima Daisuke , Hung Chin-Te , Liu Shang-Bin 
Published: May 2020

Abstract
Herein, the synthesis of heteroatom-containing graphene-like carbon nanosheets (HA-GCNs) by chemical activation of waste biomass, namely peanut shells. As characterized by a variety of analytical and spectroscopy techniques, the as-synthesized HA-GCNs material carbonized at 900 °C was found to possess sheet-like porous nanosheet morphology with high surface areas (>800 m2 g−1) and desirable of heteroatom contents such as nitrogen (N; 0.84 atom%), and oxygen (O) as high as 20.25 atom%, which greatly improved the electronic properties of the carbon substrate for prospective applications as metal-free electrodes and electrocatalytic materials. The HA-GCNs were found to exhibit a superior specific capacitance of 148, 145, 125, and 105 F g−1 corresponding to the KOH, NaOH, LiOH, and H2SO4 electrolyte solutions, respectively. Although, the HA-GCNs electrode exhibited extraordinary electrochemical performances and cyclic charge-discharge stabilities. Moreover, these novel HA-GCNs exhibited excellent electrocatalytic activities and cyclic stabilities for oxygen reduction reaction (ORR) with a desirable current density of 1.17 mA cm−2 in O2-saturated 0.1 M KOH solution, surpassing that of noble metal-incorporated activated carbons. The superior electrochemical and electrocatalytic performances observed for the HA-GCNs were attributed to the unique pseudocapacitive behavior of the oxygen surface functional groups as well as their unique textural properties, rendering practical applications as low-cost electrodes for supercapacitors and metal-free electrocatalysts for ORR.