bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penguatan kapasitas peran masjid sebagai pusat pemberdayaan masyarakat di Kelurahan Taman Sari Ampenan Kota Mataram
Authors: Asyari Akhmad , Acim Subhan Abdullah 
Published: April 2020

[Bahasa]: Berdasarkan hasil observasi awal yang telah dilakukan ditemukan permasalahan yang urgen untuk ditindak lanjuti yaitu rendahnya pemahaman keagaamaan masyarakat dan rentannya pengaruh budaya disebabkan masyarakat yang menetap dan tinggal di kelurahan taman sari Ampenan ini sangat heterogen dari suku, kepercayaan dan latar belakang. Untuk mencegah dampak negatif yang terjadi maka masjid harus difungsikan sebagai sarana dan fungsi/peran kapasitas masjid tidak hanya sebagai tempat melaksanakan ibadah, tetapi masjid harus dijadikan sebagai pusat pemberdayaan masyarakat. Kegiatan pendidikan dan penyuluhan dilaksanakan pada hari jum’at-sabtu tanggal 05-06 Agustus 2017 yang bertempat di masjid Al Falah dengan jumlah peserta sejumlah 30 orang dan terdiri dari 2 orang Narasumber yaitu bapak Dr. H. Zaidi Abdad, MA yang merupakan dosen UIN Mataram pada jurusan Ekonomi Islam dan bapak M. Sa’i, MA yang juga akademisi yaitu dosen fakultas Dakwah IAIN Mataram. Adapun kesimpulan dari kegiatan ini adalah; (1) Kegiatan pengabdian dapat terlaksana dengan lancar yang tercermin dari maksimalnya peran dari setiap tim pelaksana kegiatan pengabdian. (2) Berubahnya pola pikir masyarakat terhadap pentingnya pemberdayaan masjid. (3) Meningkatnya pemahaman keagamaan masyarakat yang lebih moderat dalam melihat masjid bukan sekedar sebagai tempat melaksanakan ibadah, tetapi masjid justru berperan sebagai pusat pemberdayaan masyarakat. (4) Meningkatnya pemahaman masyarakat terkait dengan konsep kapasitas peran masjid sebagai pusat pemberdayaan. (5) Tersampaikannya informasi terkait dengan penguatan kapasitas peran masjid sebagai pusat pemberdayaan. (6) Meningkatnya pemahaman masyarakat untuk menjadikan masjid sebagai pusat pemberdayaan masyarakat.
Kata Kunci: kapasitas peran masjid, pusat pemberdayaan masyarakat, Tamansari Ampenan Kota Mataram
Membangun inovator kampung melek media (pendampingan remaja melalui program edukasi literasi media)
Authors: Ahyar Ahyar 
Published: April 2020

[Bahasa]: Pendampingan remaja melalui program edukasi literasi media di Lingkungan Karang Baru Pejeruk Ampenan merupakan program dampingan yang menghadirkan kondisi baru, setidak-tidaknya telah membawa perubahan perilaku sosial remaja kendati perubahan tersebut tidak terlalu cepat, lebih-lebih dalam program yang bersifat dampingan yang berbasis kepada perubahan pola pikir, perilaku, dan cara pandang masyarakat. Program dampingan seperti ini membutuhkan waktu yang relatif lama tidak seperti halnya program yang bersifat fisik yang mudah dilihat, mudah diukur capaiannya dan keberhasilannya. Tim telah berusaha membangun kesadaran komunitas tentang pentingnya literasi media. Membangun kesadaran kepada komunitas remaja sebagai inovator bukanlah pekerjaan yang mudah, namun tidak mesti harus dihindari karena program ini dipandang cukup memberikan manfaat positif kepada remaja. Hasil dampingan menunjukkan adanya kemauan, inisiatif remaja sebagai inisiator sekaligus sebagai inovator di lingkungannya dalam merubah cara pandang remaja dalam mengkonsumsi media dengan memanfaatkan forum-forum atau kelompok-kelompok warga, seperti yasinan remaja, hiziban, serakalan, dan pengajian remaja.
Kata kunci: inovator, media, literasi media
Role of Gene Polymorphisms of Matrix Metalloproteinases-2, -3 and -13 in the Development of Coronary Artery Atherosclerosis in Patients with Primary Polyosteoarthrosis
Authors: Portyannikova O. O. , Romanova E. N. , Govorin A. V. , Tsvinger S. M. 
Published: April 2020

The aim of the research. To assess the influence of polymorphisms of the matrix metalloproteinase genes — 2 (rs2285053), — 3 (rs3025058), and — 13 (rs2252070) on the development of coronary atherosclerosis in patients with primary osteoarthritis.Materials and methods. The polymorphisms of the Thе pоlymоrphisms оf thе matrix metalloproteinase genes — 2 (rs2285053), — 3 (rs3025058), and — 13 (rs2252070) and their connection with development of atherosclerosis in patients with osteoarthritis were determined.Results. In the process of studying the polymorphism (rs2252070 T/C) of the MMP — 13 gene, it was revealed that the carriage of the homozygous T allele of the MMP-13 gene polymorphism is 1,8 times higher in the group of patients without verified coronary atherosclerosis in comparison with a group of patients with verified coronary atherosclerosis. This fact shows that this genotypic variant is protective in relation to the development of atherosclerotic lesions of the coronary vessels. The heterozygous variant of the T/C genotype was more common in the group of patients with verified coronay atherosclerosis — 59%. The calculation of the odds ratio shows that the possibility of developing coronary atherosclerosis in patients with this genotype is 2,7 times higher than in patients with a homozygous grnotypic variant.Conclusion. It is shown that the heterozygous variant of rs2252070 T/C matrix metalloproteinase 13 increases the chance of developing coronary atherosclerosis in patients with osteoarthritis.
ARGUMENTS OF DIGNITY AND PLURALISM CONCERNS IN RECENT CONSTITUTIONAL COURT ADJUDICATION
Authors: Sperti Angioletta 
Published: April 2020

The paper aims at discussing the growing importance of dignity discourse in human rights case law, in particular in recent constitutional and supreme courts cases on controversial rights. Starting from same-sex marriage rulings (as illustrative of a more general trend) the paper argues that dignity cannot be considered a mere “rhetorical tool” of courts, useful to tilt the balance in favour of one of the conflicting rights. On the contrary, dignity - with its wide and flexible meaning - marks the transition of new (or newly recognized) groups to social inclusion and provides a convenient language to mediate among conflicting claims of recognition without relying on more traditional equality arguments.
Mechanisms of Bone Tunnel Enlargement Following Anterior Cruciate Ligament Reconstruction
Authors: Yue Li , DeFroda Steven F. , Sullivan Kayleigh , Garcia Dioscaris , Owens Brett D. 
Published: April 2020

» Although anterior cruciate ligament reconstruction (ACL-R) yields generally favorable results, bone tunnel enlargement (BTE) commonly has been reported after ACL-R.» While the exact clinical ramifications of tibial widening on functional outcomes are variable, it is thought that widening may potentially play a role in late failure following ACL-R.» The prevalence of tunnel enlargement is related particularly to hamstring autografts, with some authors reporting rates ranging from 25% to 100% in femoral tunnels and 29% to 100% in tibial tunnels after ACL-R.» BTE is difficult to manage, particularly in the setting of revision ACL-R. The mechanisms underlying BTE after ACL-R are associated with a complex interplay between biological and mechanical factors.
Triceps Tendon Ruptures
Authors: Gaviria Manuela , Ren Beth , Brown Symone M. , McCluskey Leland C. , Savoie Felix H. , Mulcahey Mary K. 
Published: April 2020

» Triceps tendon ruptures (TTRs) are rare and often occur as a result of falling on an outstretched hand, forceful eccentric contraction, direct trauma to the elbow, or lifting against resistance.» TTRs are most commonly seen in middle-aged men, football players, and weightlifters.» Radiography, ultrasonography, and magnetic resonance imaging may be utilized for diagnosis and to guide treatment.» Acute partial TTRs may have good outcomes with nonoperative management. Surgery should be considered if nonoperative treatment is unsuccessful or if substantial musculotendinous retraction is present.» Surgical repair is strongly recommended for complete TTRs.
Tibial Slope and Anterior Cruciate Ligament Reconstruction Outcomes
Authors: Lin Lawrence J. , Akpinar Berkcan , Meislin Robert J. 
Published: April 2020

» The tibial slope represents an important risk factor for both primary anterior cruciate ligament (ACL) injury and subsequent reconstruction failure.» A high tibial slope has been associated with increased anterior tibial translation, increased strain on the ACL, and increased posteromedial compartment contact pressure.» Patients with ACL-deficient knees who also have coronal tibiofemoral malalignment may potentially benefit from concomitant high tibial osteotomy and ACL reconstruction.» Understanding the impact of the tibial slope on ACL reconstruction outcomes and the treatment options with regard to coronal tibiofemoral alignment allows for the appropriate care of patients with both morbidities.
Cartografiando el movimiento de justicia ambiental a escala regional: el mapa digital colaborativo de los conflictos del agua en Andalucía
Authors: Del Moral Ituarte Leandro , Laconi Cesare , Pedregal Belén 
Published: April 2020

Apoyándose en experiencias anteriores desarrolladas a diferentes escalas, este artículo propone la investigación colaborativa entre académicos y sociedad en general como el enfoque necesario para entender en profundidad los conflictos ambientales en una perspectiva regional. Con este objetivo, el artículo presenta, en primer lugar, la metodología y el proceso de construcción del Mapa colaborativo de los conflictos del agua en Andalucía (Mapa-RedNCA) y describe su diseño y desarrollo incardinado en organizaciones sociales preexistentes; en segundo lugar, presenta sus resultados iniciales y valora sus potencialidades como herramienta útil para académicos y organizaciones comprometidas con la justicia ambiental. El artículo finaliza argumentando que el Mapa-RedNCA puede contribuir a mejorar el conocimiento sobre los conflictos ecológicos distributivos, transcendiendo los estudios de casos individuales, ofreciendo una visión sistemática y apoyada empíricamente sobre las tipologías de los conflictos y actores involucrados, las formas de movilización, los aspectos relacionados con información y participación, y la dimensión cultural y patrimonial que caracterizan las luchas por la justicia ambiental a escala local y regional.
Genome-wide association mapping of Sclerotinia sclerotiorum resistance in soybean using whole-genome resequencing data
Authors: Boudhrioua Chiheb , Bastien Maxime , Torkamaneh Davoud , Belzile François 
Published: April 2020

Abstract
Background: Sclerotinia stem rot (SSR), caused by Sclerotinia sclerotiorum (Lib.) de Bary, is an important cause of yield loss in soybean. Although many papers have reported different loci contributing to partial resistance, few of these were proved to reproduce the same phenotypic impact in different populations. Results: In this study, we identified a major quantitative trait loci (QTL) associated with resistance to SSR progression on the main stem by using a genome-wide association mapping (GWAM). A population of 127 soybean accessions was genotyped with 1.5M SNPs derived from genotyping-by-sequencing (GBS) and whole-genome sequencing (WGS) ensuring an extensive genome coverage and phenotyped for SSR resistance. SNP-trait association led to discovery of a new QTL on chromosome 1 (Chr01) where resistant lines had shorter lesions on the stem by 29 mm . A single gene (Glyma.01g048000) resided in the same LD block as the peak SNP, but it is of unknown function. The impact of this QTL was even more significant in the descendants of a cross between two lines carrying contrasted alleles for Chr01. Individuals carrying the resistance allele developed lesions almost 50% shorter than those bearing the sensitivity allele. Conclusion: These results suggest that the new region on chromosome 1 harbors a promising resistance QTL to SSR that can be used in soybean breeding program.
Involvement of the IP3R-Grp75-VDAC1-MCU calcium axis in proteinuria in adriamycin-induced nephropathy rats
Authors: Wang Si-Si , Xu Han , Guan Na , Wei Qi-Jiao , Tao Ying-Hong , Yang Guo-Sheng , Ren Ya-Li 
Published: April 2020

Abstract
Background: Podocyte injury plays a key role in the development of proteinuria. We previously found that the intracellular inositol 1, 4, 5-trisphosphate receptor (IP3R)- glucose-regulated protein 75 (Grp75)- voltage dependent anion channel 1 (VDAC1)- mitochondrial calcium uniporter (MCU) calcium axis contributes to podocyte injury in cultured mouse podocytes. This study investigated whether the IP3R-Grp75-VDAC1-MCU calcium axis is involved in the development and improvement of proteinuria in nephropathy rats. Methods: The expression of members of the IP3R-Grp75-VDAC1-MCU calcium axis in the renal cortex of a previously established adriamycin (ADR)-induced nephropathy rat model and cultured mouse podocytes was investigated by western blot analysis and immunohistochemical staining. The effects of ruthenium red (RR), an MCU inhibitor, on interactions in the IP3R-Grp75-VDAC1-MCU calcium axis were investigated by in vitro co-immunoprecipitation assays. Results: In adriamycin induced nephropathy rat, the expression of members of the glomerular IP3R-Grp75-VDAC1-MCU calcium axis increased significantly compared with the normal control rats. RR inhibited the upregulation of members of the IP3R-Grp75-VDAC1-MCU calcium axis induced by ADR and their interactions. Conclusion: The IP3R-Grp75-VDAC1-MCU calcium axis is involved in proteinuria in ADR-induced nephropathy and can be inhibited by RR.
Content Development for a Physical Activity and Sedentary Behaviour e-Learning Module for Early Childhood Education Students: A Delphi Study
Authors: Bruijns Brianne , Johnson Andrew M. , Tucker Trish 
Published: April 2020

Abstract
Background: Early childhood educators play a prominent role in promoting healthy activity behaviours in childcare. However, they have expressed that they lack the appropriate pre-service training to confidently lead physical activity (PA), and minimize sedentary behaviour (SB), in childcare. As such, the purpose of this Delphi study was to generate and reach agreement on content areas for inclusion in a PA and SB e-Learning module for Early Childhood Education (ECE) students.Methods: Purposeful sampling of Canadian/international researchers was used to form two expert panels: a PA/SB expert panel (n = 26), and a Canadian ECE panel. The PA/SB experts suggested their top 12 PA/SB topics for the module via online survey. These topics were then pooled to generate a list of 19 content areas. In a second online survey, both panels of experts rated the importance of each content area (0 = unimportant to 5 = very important). Mean ratings (M) were ranked separately for each panel, and then ratings were pooled to create an overall ranking of the 19 content areas. Inter-panel agreement of importance rankings was visually represented as a scatterplot and quantified using Spearman’s rho (rs).Results: The top-rated content area was Outdoor Play (M = 4.77 ± .64), followed by Benefits of PA in the Early Years (M = 4.75 ± .66), and Factors Influencing PA and SB in Childcare (M = 4.71 ± .74). Monitor PA and Sedentary Time Within Your Classroom had the lowest combined score (M = 3.77 ± 1.44). There was moderate-to strong inter-panel agreement for content area importance rankings (rs = 0.60, 95% CI: 0.20 to 0.83). The majority of the ECE expert panel considered this training important for ECE students (94.3%), aligning with ECE curriculum objectives (91.4%) and accreditation standards (78.8%), and complementary to the present ECE curriculum (88.6%).Conclusions: Providing PA and SB training to ECE students is a proactive way to ensure healthy movement behaviours are prioritized in childcare programming. With the PA/SB expert-developed content areas, and endorsement by the ECE expert panel, implementing this training within ECE programs is a necessary next step.
Patients with pheochromocytoma exhibit low aldosterone renin ratio-preliminary reports
Authors: Yamada Tomoko , Fukuoka Hidenori , Hosokawa Yusei , Odake Yukiko , Yoshida Kenichi , Matsumoto Ryusaku , Bando Hironori , Okada Yuko , Hirota Yushi , Iguchi Genzo , Ogawa Wataru , Takahashi Yutaka 
Published: April 2020

Abstract
Background Plasma renin activity (PRA) is generally increased in patients with pheochromocytoma (PCC) due to low circulating plasma volume and activation of β-1 adrenergic receptor signaling. However, there has been no study on the aldosterone renin ratio (ARR) in patients with PCC. To elucidate the issue, this study aimed to determine the PRA, plasma aldosterone concentration (PAC), and ARR in patients with PCC and compare them with those in patients with subclinical Cushing’s syndrome (SCS) and non-functioning adrenal adenoma (NFA).Methods In this retrospective single-center, cross-sectional study, 67 consecutive patients with adrenal tumors (PCC (n =18), SCS (n =18), and NFA (n =31)) diagnosed at Kobe University Hospital between 2008 and 2014 were enrolled.Results PRA was significantly higher in patients with PCC than in those with SCS and NFA (2.1 (1.3~2.8) vs. 0.7 (0.5~1.8) and 0.9 (0.6~1.4) ng/mL/h; p =0.018 and p =0.025). Although PACs were comparable among the three groups, ARR was significantly lower in patients with PCC than in those with SCS and NFA (70.5 (45.5~79.5) vs. 156.0 (92.9~194.5) and 114.9 (90.1~153.4); p =0.001 and p <0.001). Receiver operating characteristic curve analysis demonstrated that, in differentiating PCC from NFA, PRA >1.55 ng/mL/h showed a sensitivity of 70.0% and specificity of 80.6%. Interestingly, ARR <95.4 showed a sensitivity of 83.3% and specificity of 86.7%, which were higher than those in PRA.Conclusions ARR decreased in patients with PCC, which was a more sensitive marker than PRA. Further study is necessary to understand the usefulness of this convenient marker in the detection of PCC. Trial registrationThis study was not registered because of the retrospective analysis.
Impact of 3D genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene expression in mouse liver
Authors: Matthews Bryan J , Waxman David J 
Published: April 2020

Abstract
Several thousand sex-differential distal enhancers have been identified in mouse liver; however, their links to sex-biased genes and the impact of any sex-differences in nuclear organization and chromatin interactions are unknown. To address these issues, we first characterized 1,847 mouse liver genomic regions showing significant sex differential occupancy by cohesin and CTCF, two key 3D nuclear organizing factors. These sex-differential binding sites were primarily distal to sex-biased genes but rarely generated sex-differential TAD (topologically associating domain) or intra-TAD loop anchors, and were sometimes found in TADs without sex-biased genes. A substantial subset of sex-biased cohesin-non-CTCF binding sites, but not sex-biased cohesin-and-CTCF binding sites, overlapped sex-biased enhancers. Cohesin depletion reduced the expression of male-biased genes with distal, but not proximal, sex-biased enhancers by >10-fold, implicating cohesin in long-range enhancer interactions regulating sex-biased genes. Using circularized chromosome conformation capture-based sequencing (4C-seq), we showed that sex differences in distal sex-biased enhancer - promoter interactions are common. Intra-TAD loops with sex-independent cohesin-and-CTCF anchors conferred sex specificity to chromatin interactions indirectly, by insulating sex-biased enhancer - promoter contacts and by bringing sex-biased genes into closer proximity to sex-biased enhancers. Furthermore, sex-differential chromatin interactions involving sex-biased gene promoters, enhancers, and lncRNAs were associated with sex-biased binding of cohesin and/or CTCF. These studies elucidate how 3D genome organization impacts sex-biased gene expression in a non-reproductive tissue through both direct and indirect effects of cohesin and CTCF looping on distal enhancer interactions with sex-differentially expressed genes.
Identification of Nucleus Sterility Candidate Genes using a Resequencing Technique in Sweet Pepper Sterile Line AB91
Authors: Meng Yaning , Yan Libin , Zhang Hongxiao , Fan Yanqin 
Published: April 2020

Abstract
Background : Breeding hybrids with nuclear malesterile lines is an important method for the cross breeding of sweet peppers. To date, few reports have been published on the nuclear malesterility gene of sweet pepper.Yet, there are approximately 20 pepper nuclear malesterility lines in the world. Results: Using the self-developed testing material, sweet pepper nuclear malesterile dual-purpose line AB91, the genome-wide resequencing technique was applied to firstly find that the mutation site causing the abortion of sweet pepper nuclear malesterility AB91 is on chromosome #5. The mutation gene Capana05g000747 was filtered out and validated by the flight mass spectrometry genotyping and quantitative real-time PCR method and determined to be the gene causing the abortion of sweet pepper nuclear male sterility AB91.The gene Capana05g000747 mutation site is a non-synonymous mutation site located at the 6th exon,the base C mutated into A, and the amino acid changed from alanine to serine. The three-dimensional protein structure of fertile and sterile plant Capana05g000747 was predicted. The results showed that the three-dimensional structure of the two proteins was differed significantly. Sequence alignment analysis showed that the gene Capana05g000747 has a similar function to gene At2g02148. The gene At2g02148 contains a pentatricopeptide repeatprotein which has important physiological functions in the gene expression process of organelles and is closely related to the performance of malesterility genes. Conclusions : This study revealed that Capana05g000747 was selected as an important candidate gene for sweet pepper nuclear male sterile testingmaterial AB91.This gene provides a theoretical and technical foundation for further cloning as well as transformation and utilization of the gene.
Subcellular localization of fibroblast growth factor receptor type 2 and correlation with CTNNB1 genotype in adrenocortical carcinoma
Authors: Haase Matthias , Thiel Anne , Scholl Ute I. , Ashmawy Hany , Schott Matthias , Ehlers Margret 
Published: April 2020

Abstract
Objective: Fibroblast growth factor receptor (FGFR) 2 regulates the development of the adrenal gland in mice. In addition, FGFR2-mediated signalling has been shown to prevent apoptosis and to enhance proliferation in adrenocortical precursor cells. The activation of the Wingless/Int-1 (WNT) / beta catenin pathway as a key mechanism of adrenocortical tumourigenesis has been linked to FGFR2 signalling in other cell types. Therefore we hypothesised that FGFR2 expression may also play a role in adrenocortical carcinoma (ACC). We conducted a pilot study and analysed protein expression of FGFR2 in 26 ACCs using immunohistochemistry technique. Data on the CTNNB1 mutation status and clinical data were correlated to the expression of FGFR2. Results: We observed a high variability in FGFR2 expression between the different tumour samples. There was a subset of ACC with comparatively high nuclear expression of FGFR2. We did not find a clear association between the CTNNB1 mutational status or clinical features and the FGFR2 expression. We conclude that FGFR signalling plays a role in adrenocortical carcinoma. Our data encourages further investigations of FGFR signalling in ACC, especially since new inhibitors of FGFR signalling are already entering clinical trials for the treatment of other cancer types.