bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Selenoprotein P 3’ untranslated region is an RNA binding protein platform that fine tunes selenocysteine incorporation
Authors: Shetty Sumangala P. , Kiledjian Nora T. , Copeland Paul R. 
Published: November 2020

ABSTRACTSelenoproteins contain the 21st amino acid, selenocysteine (Sec), which is incorporated at select UGA codons when a specialized hairpin sequence, the Sec insertion sequence (SECIS) element, is present in the 3’ UTR. Aside from the SECIS, selenoprotein mRNA 3’ UTRs are not conserved between different selenoproteins within a species. In contrast, the 3’-UTR of a given selenoprotein is often conserved across species, which supports the hypothesis that cis-acting elements in the 3’-UTR other than the SECIS exert post-transcriptional control on selenoprotein expression. In order to determine the function of one such SECIS context, we chose to focus on the plasma selenoprotein, SELENOP, which is required to maintain selenium homeostasis as a selenium transport protein that contains 10 Sec residues. It is unique in that its mRNA contains two SECIS elements in the context of a highly conserved 843-nucleotide 3’ UTR. Here we have used RNA affinity chromatography and identified PTBP1 as the major RNA binding protein that specifically interacts with the sequence between the two SECIS elements. We then used CRISPR/Cas9 genome editing to delete two regions surrounding the first SECIS element. We found that these sequences are involved in regulating SELENOP mRNA and protein levels, which are inversely altered as a function of selenium concentrations.
Beyond fear centers - a distributed fMRI-based neuromarker for the subjective experience of fear
Authors: Zhou Feng , Zhao Weihua , Qi Ziyu , Geng Yayuan , Yao Shuxia , Kendrick Keith M. , Wager Tor D. , Becker Benjamin 
Published: November 2020

AbstractThe specific neural systems underlying the subjective feeling of fear remain vigorously debated in affective neuroscience. Here, we combined functional MRI with machine learning to identify and evaluate a sensitive and generalizable neural signature predictive of the momentary self-reported subjective fear experience across discovery (n=67), validation (n=20) and generalization (n=31) cohorts. We systematically demonstrate that accurate fear prediction crucially requires distributed brain systems, with important contributions from cortical (e.g., prefrontal, midcingulate and insular cortices) and subcortical (e.g., thalamus, periaqueductal gray, basal forebrain and amygdala) regions. We further demonstrate that the neural representation of subjective fear is distinguishable from the representation of conditioned threat and general negative affect. Overall, our findings suggest that subjective fear, which exhibits distinct neural representation with some other aversive states, is encoded in distributed systems rather than isolated ‘fear centers’. This signature provides a neuromarker for monitoring fear-related neuropathology and evaluating novel treatments targeting pathological fear.
Effects of zirconium addition on electrochemical and mechanical properties of Mg-3Zn-1Ca-1RE alloy
Authors: Mousavian Seyed Mohammad Hossein , Tabaian Seyed Hadi , Badihehaghdam Mohammadhassan 
Published: November 2020

Purpose
The effect of zirconium, zinc, calcium and rare earth group as the alloying elements on mechanical properties and corrosion behavior of magnesium alloys was investigated in the simulated body fluid.

Design/methodology/approach
Pure magnesium and the alloying elements were melted and zirconium was finally added to obtain different alloys. The castings were annealed and some samples were aged heat treated. X-ray fluorescence was used for the elemental analysis and LSV was used for electrochemical corrosion evaluations.

Findings
Results showed that corrosion resistance decreases with increasing zirconium content. The lowest corrosion rate was obtained for the samples containing 0.3% and 0.45% of Zr from annealed and aging heat-treated samples, respectively. Yield stress enhances with increasing the zirconium content and degrades by the aging heat treatment.

Originality/value
These alloys were studied for the first time. Effect of casting without using protective flux and vacuum furnaces. Effect of annealing at 440°C for 2 h and artificial aging at 200°C for 16 h. Alloy’s electrochemical behavior on the body’s simulation environment has been investigated. Improvement of mechanical properties after annealing heat treatment by high zirconium percentage.
A systematic literature review on supply chain risk management: is healthcare management a forsaken research field?
Authors: Senna Pedro , Reis Augusto , Santos Igor Leão , Dias Ana Claudia , Coelho Ormeu 
Published: November 2020

PurposeThis paper aims to present a systematic literature review (SLR) to investigate how supply chain risk management (SCRM) is applied to the healthcare supply chains and which improvement opportunities are being missed in this segment.Design/methodology/approachThis SLR used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method to answer three research questions: (1) Which are the main gaps concerning healthcare supply chain risk management (HCSCRM)? (2) What is the definition of HCSCRM? and (3) What are the risk management techniques and approaches used in healthcare supply chains?FindingsThe authors present a complete summary of the HCSCRM body of research, investigating research strings like clinical engineering and high reliability organizations (HROs) and its relations with HCSCRM; (1) This research revealed the five pillars of HCSCRM; (2) The authors proposed a formal definition for HCSCRM considering all the literature blocks explored and (3) The authors generated a list of risks present in healthcare supply chains resulting from extensive article research.Research limitations/implicationsThe authors only reviewed international journal articles (published in the English language), excluding conference papers, dissertations and theses, textbooks, book chapters, unpublished articles and notes. In addition, the study did not thoroughly investigate specific countries' particularities concerning how the healthcare providers are organized.Originality/valueThe contribution of this article is threefold: (1) To the best of authors knowledge, there is no other SLR about HCSCRM published in the scientific literature by the time of realization of authors’ work, suggesting that is the first effort to fulfill this research gap; (2) Following the previous contribution, in this work the authors propose a first formal definition for HCSCRM and (3) The authors analyzed concepts such as clinical engineering and HROs to establish the building blocks of HCSCRM.
Developing a QFD model for prioritizing the CSFs of ERP based on the enablers of organizational agility
Authors: Ahmadzadeh Ali , Sheikh Aboumasoudi Abbas , Shahin Arash , Teimouri Hadi 
Published: November 2020

PurposeThe main purpose of this study is to develop a model for prioritizing the critical success factors (CSF) of enterprise resources planning (ERP) based on the enablers of organizational agility (OA).Design/methodology/approachFirst, the CSFs of ERP and the enablers of OA have been identified and classified using Decision-Making Trial and Evaluation Laboratory (DEMATEL), and then a three-phase quality function deployment (QFD) model has been designed to prioritize the influencing and influenced criteria. The proposed approach has been examined in the banking sector.FindingsMajor findings indicated that organizational structure, IT technology infrastructure, and commitment and support by top managers were selected as indicators with top priority.Research limitations/implicationsResearch variables were limited to the enablers of OA and the CSFs of ERP; analysis was time-consuming due to the interconnected multiple QFD phases, and findings were limited to the selected branches of a bank. The bank managers were suggested to enhance their commitment and support toward ERP. Also, it was recommended to the managers to evaluate their organizational structure and empower it as much as possible toward the fulfillment of customers' requirements and customers' expected agility.Originality/valueThe development of the QFD matrices and dividing the factors of each research variables into influencing and influenced factors distinguished this study from the literature.
Performance implications of combining creative and imitative innovation strategies
Authors: Moon Changho , Acquaah Moses 
Published: November 2020

PurposeThe purpose of this study is to investigate the performance effects of pure innovation strategies (creative and imitative) versus the combination of the two innovation strategies (combination innovation strategy) and to determine whether implementing the combination innovation strategy produces an incremental performance benefit over the pure innovation strategies.Design/methodology/approachWe used archival data from the Korea Innovation Survey (KIS) completed by a large sample of South Korea manufacturing firms and some financial data provided by the South Korea Science and Technology Policy Institute (STEPI). We used hierarchical multiple regression analysis to analyze the data from 486 firms.FindingsThe findings indicated that firms implementing any of the three innovation strategies of creative innovation, imitative innovation and combination innovation outperforms noninnovators. Results also show that while firms implementing the combination innovation strategy perform better than those implementing imitative innovation strategies, they do not significantly differ in performance from firms implementing the creative innovation strategy. Moreover, we find no performance difference between creative innovation and imitative innovation strategies.Practical implicationsThe study highlights the importance of combination innovation strategies for manufacturing firms that rely on imitative innovation strategies to gain competitive advantage in the market. However, it demonstrates that firms that are successful in using creative innovation strategies must use their resources in exploiting that advantage.Originality/valueAlthough extant studies have demonstrated the importance of both creative innovation and imitative innovation strategies in enhancing performance, it is not clear whether implementing both strategies at the same time has incremental value for firms. This study focusses on empirically examining the performance implications of creative innovation and imitative innovation strategies, and whether the pursuit of a combination innovation strategy (simultaneous pursuit of both innovation strategies) provides any incremental benefit is unique.
Enhancing customer-brand relationship by leveraging loyalty program experiences that foster customer-brand identification
Authors: Shin Minjung , Back Ki-Joon , Lee Choong-Ki , Lee Young-Sub 
Published: November 2020

Purpose
This study aims to investigate ways in which hotel loyalty programs can be designed to enhance customer’s identification with a hotel brand and develop a sustainable customer-brand relationship.

Design/methodology/approach
The study adopted a cross-sectional design survey questionnaire for data collection and used structural equation modeling data analysis to test the conceptual model.

Findings
The three loyalty program experiences proposed (member-to-member similarity, memorable loyalty program experience and loyalty program social benefits) exerted significant positive effects on customer-brand identification (CBI), which, in turn, influences customer-brand relationship elements, including trust, commitment and switching resistance.

Originality/value
This study expands the scope of CBI literature, which previously focused substantially on brand level experiences, by being the first to explore a new set of CBI antecedents with a focus on loyalty program experiences. Furthermore, the current study’s findings delineate specific strategies to uphold the social and experiential aspects of loyalty programs that can develop sustainable customer-brand relationships.
Troubled IS/IT projects: searching for the root causes
Authors: Rocchi Paolo , Za Stefano 
Published: November 2020

Purpose
For decades, troubled information systems (IS)/information technology (IT) projects have continued to lose billions of dollars all over the world. The purpose of this paper is to look for the root causes of this widespread and important phenomenon.

Design/methodology/approach
This paper begins with a concise survey of empirical research and shows that a significant proportion of project failures are derived from the behavior of managers rather than from objective or technical obstacles. Although researchers have made significant efforts to improve the professional conduct of managers, the situation ameliorated only slowly. This raises the issue of a possible hidden cause lying behind the perceived determinants of failure; the authors, therefore, look for the root-cause of this broad noteworthy phenomenon and apply the techniques typical of “root-cause analysis”.

Findings
IS/IT managers handling troubled projects worldwide have nothing in common except for a similar cultural basis. As students, they learned the fundamental concepts of informatics, and it is, therefore, natural to hypothesize a specific cause and effect relationship between these lessons and the ineffective behaviors of managers. A careful analysis shows that computing theories are narrow, self-referential and abstract, and this negatively affects the conduct of managers, who have broad, practical responsibilities.

Practical implications
The cultural causes of runaway projects require advanced theoretical research on the foundations of computer science to create a comprehensive and consistent construct that can support the manifold duties of IS/IT project leaders. A future theoretical structure will underpin innovative courses in universities and professional organizations, making leaders more aware of their roles and more capable of managing them.

Originality/value
In general, when a problem is traced to its origin, it can be eradicated. This work offers evidence that the root causes of troubled projects lie in the management culture, and therefore, the professional preparation of managers needs to be improved so to remove the present difficulties in IS/IT projects.
Reduction of severe acute respiratory syndrome coronavirus‐2 infectivity by admissible concentration of ozone gas and water
Authors: Murata Takayuki , Komoto Satoshi , Iwahori Satoko , Sasaki Jun , Nishitsuji Hironori , Hasebe Terumitsu , Hoshinaga Kiyotaka , Yuzawa Yukio 
Published: November 2020

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is causing the global coronavirus disease 2019 (COVID‐19) pandemic. Because complete elimination of SARS‐CoV‐2 appears difficult, decreasing the risk of transmission is important. Treatment with 0.1 and 0.05 ppm ozone gas for 10 and 20 hr, respectively, decreased SARS‐CoV‐2 infectivity by about 95%. The magnitude of the effect was dependent on humidity. Treatment with 1 and 2 mg/L ozone water for 10 s reduced SARS‐CoV‐2 infectivity by about 2 and 3 logs, respectively. Our results suggest that low‐dose ozone, in the form of gas and water, is effective against SARS‐CoV‐2.
Frugivory underpins the nitrogen cycle
Authors: Villar Nacho , Paz Claudia , Zipparro Valesca , Nazareth Sergio , Bulascoschi Leticia , Bakker Elisabeth S. , Galetti Mauro 
Published: November 2020

Abstract

Tropical rainforests are populated by large frugivores that feed upon fruit‐producing woody species, yet their role in regulating the cycle of globally important biogeochemical elements such as nitrogen is still unknown. This is particularly relevant because tropical forests play a prominent role in the nitrogen cycle and are becoming rapidly defaunated. Furthermore, frugivory is not considered in current plant‐large herbivore‐nutrient cycling frameworks exclusively focused on grazers and browsers.

Here we used a long‐term replicated paired control‐exclusion experiment in the Atlantic Forest of Brazil, where peccaries and tapirs are the largest native frugivores, to examine the impact of large ground‐dwelling frugivores on modulating soil nitrogen cycling, considering their effects across a gradient of abundance of a hyper‐dominant palm.

We found that both large frugivores and dominant palms play a substantial role in modulating ammonium availability and nitrification rates. Large frugivores increased ammonium by 95%, which also increased additively with palm abundance. Nitrification rates increased with palm abundance in the presence of large frugivores, but not on exclosure plots. Large frugivores also stimulated the regulation of the functions of soil‐nitrifying microorganisms, and modulated the landscape‐scale variance in nitrogen availability. Such joint effects of large frugivores and palms are consistent with the notion of ‘fruiting lawns’.

Our study indicates that frugivory plays a pivotal role in zoogeochemistry in tropical forests by regulating and structuring the nitrogen cycle, urging to accommodate frugivory in plant‐large herbivore‐nutrient cycling frameworks. It also indicates that defaunation, deforestation and illegal palm and timber harvesting seriously affect nitrogen cycling in tropical forests, that play a prominent role in the global cycle of this nutrient.

A free Plain Language Summary can be found within the Supporting Information of this article.
Unexpected death in a young man associated with a unilateral swollen leg: Pathological and toxicological findings in a fatal snakebite from Deinagkistrodon acutus (Chinese moccasin)
Authors: Huang Fang , Zhao Shuquan , Tong Fang , Liang Yue , Le Grange Jehane Michael , Kuang Wenhua , Zhou Yiwu 
Published: November 2020

AbstractDeinagkistrodon acutus (D. acutus), also known as the Chinese moccasin, is a viper species found throughout the southeastern parts of China, northern Vietnam and Laos. D. acutus envenomation can result in coagulopathy and lead to death if not treated correctly. A 20‐year‐old man was discovered with a severely swollen left thigh with overlying dark purple, discolored skin. He was immediately transported to hospital. Laboratory examinations revealed dysfunctional coagulation and fluid‐electrolyte imbalances. He died 2 h later despite resuscitation efforts. Surveillance footage revealed that he had walked through a grass field while returning home that night. Autopsy and pathological examination findings revealed a large area of muscle necrosis of the left thigh, renal tubular necrosis, and hepatocyte necrosis. Potential fang marks were found on the decedent's jeans. Due to our suspicions, we performed specific enzyme‐linked immunosorbent assays (ELISA) and detected D. acutus venom in the kidneys, left thigh muscle, liver, lung, spleen, and heart tissues of the decedent. In conclusion, the clinical manifestations, autopsy, histopathological examination, ELISA, and investigation results confirmed D. acutus envenomation.
Statistical comparisons of blood alcohol samples from 6‐mL and 10‐mL grey‐top tubes
Authors: Olds Maria L. , Naquin Jennifer L. 
Published: November 2020

AbstractHistorically, blood alcohol concentration (BAC) studies utilized a 1% concentration of the preservative sodium fluoride (NaF), leaving an information gap supporting usage of lower concentrations of NaF to preserve ethanol. As many forensic laboratories utilize Becton, Dickinson and Company 6‐mL gray‐top tubes (0.25% NaF), statistical comparisons were conducted to determine whether significant differences exist between BAC values obtained from 6‐mL tubes versus 10‐mL tubes (1% NaF). Whole blood was spiked at three concentrations, (0.04, 0.08, and 0.15 g/100 mL) and aliquoted into tubes at “low,” “medium,” and “high” fill volumes. Tubes were split into refrigerated or ambient storage and analyzed after 1, 3, 5, 7, and 30 days, using headspace gas chromatography. Each 6‐mL and 10‐mL tube pair, prepared, stored, and analyzed under identical conditions, was compared by t‐test (95% confidence level). For refrigerated tubes, 32 of 45‐tube pairs did not reject the null hypothesis (that 6‐mL and 10‐mL tubes yield equivalent BACs), and 31 of 45 ambient stored tube pairs did not reject the null hypothesis. Analysis of variance (ANOVA) found no significant differences between 6‐mL and 10‐mL gray‐top tubes for 0.04 and 0.15 g/100 mL concentrations over 30 days; significant differences were observed for 0.08 g/100 mL concentration tubes, which warrants further study. Paired t‐tests of grouped samples found no significant differences between 6‐mL and 10‐mL tubes at any concentration.
Inferring patterns of sympatry among large carnivores in Manas National Park – a prey‐rich habitat influenced by anthropogenic disturbances
Authors: Lahkar D. , Ahmed M. F. , Begum R. H. , Das S. K. , Harihar A. 
Published: November 2020

AbstractInferring the mechanisms that facilitate sympatry amongst large mammalian carnivores in anthropogenically altered habitats is critical if conservation initiatives aimed to recover populations are to be effective. In this study, we assessed the utilization of space, time and prey resources by tigers Panthera tigris, leopards P. pardus and dholes Cuon alpinus in Manas National Park (MNP), India – a site where prey densities are not limiting, yet anthropogenic influences alter the spatial and temporal behaviour of prey. We use photographic capture data and predator scats collected over three sampling years (2014–15, 2015–16 and 2016–17) to assess patterns of (a) spatial use using a multispecies species occupancy framework, (b) time–activity patterns and overlap between predators and prey using non‐parametric circular kernel‐density functions, (c) fine‐scale spatio‐temporal behaviour by comparing time‐to‐encounters of subsequent events and (d) predator diets by analysing prey remains in predator scats. Our results highlight that the predators segregate through fine‐scale spatio‐temporal avoidance rather than displaying population‐level changes in space‐use, activity patterns or food habits. Overlap in space‐use between tigers and leopards was high and time–activity patterns of the predators closely matched those of prey, suggesting that predators likely maximize resource acquisition in this prey‐rich environment. Ungulate prey dominated the diet of predators, resulting in the high dietary overlap. From our results, we infer patterns of sympatry among large carnivores in the face of anthropogenic influences and highlight the need to understand interspecific interactions within a community before initiating conservation actions aimed at recovering these endangered species.