bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Psychiatric Disorders or uses of Psychotropic Drugs in Patients with Confirmed COVID-19 During Treatment in a Hospital : A Retrospective Chart Review Running title : Mental health of COVID-19 patients
Authors: Kim Jang Rae , Han Myung Hwa , Lee So Hee 
Published: August 2020

Abstract
BackgroundThis study aims to examine the psychiatric diagnoses, psychotropic drug use, and related factors in patients with coronavirus disease-19 (COVID-19) during their acute treatment phase.MethodsWe performed a retrospective chart review of patients admitted to the isolation ward at a nationally designated hospital during the COVID-19 outbreak. All the COVID-19 patients admitted to the hospital were assigned to psychiatrists by consultation in order to monitor their mental health during their hospital stay. We analyzed the medical records and self-reported psychological tests of 80 out of 112 patients.ResultsOn admission, 16.3% of the subjects had self-reported depression and 6.3% had post-traumatic stress disorder (PTSD). Twenty-five patients (31.3%) had current diagnoses of mental disorders. These disorders consisted of nonorganic insomnia, acute stress reaction, panic disorder, and depressive episodes. Nineteen patients (23.8%) were prescribed psychotropic drugs, including trazodone, alprazolam, clonazepam, and zolpidem. Factors associated with these psychiatric diagnoses included self-reported PTSD on the day of admission and having a spouse. Previous psychiatric history and age of 40 years or more were associated with the use of psychotropic drugs.ConclusionMental health services rendered to quarantined COVID-19 patients undergoing an acute treatment phase and self-reported PTSD on the day of admission might be useful in predicting mental health problems during hospital days.
A Research of STEAP1 on the Biological Behavior of Gastric Cancer
Authors: Zhang Zhe , Xu Huimian 
Published: August 2020

Abstract
Introduction:Six-Transmembrane Epithelial Antigene of the Prostate 1 (STEAP1) is associated with the occurrence and development of cancer. This study aimed to clarify the role of STEAP1 in gastric cancer tumor growth and metastasis, as well as its molecular mechanism of action. Methods：Statistical methods were used for clinical data analysis. Protein expression was detected using immunohistochemistry(IHC). The mRNA and protein expression in the cell cultures were detected using reverse transcription-polymerase chain reaction(RT-PCR) and western blot analysis. Overexpression and silencing models were constructed using plasmid and lentivirus transfection. To detect cell proliferation in vitro, Cell Counting Kit-8(CCK-8), flow cytometry, and colony formation assays were used; transwell and wound healing assays were used to detect cell migration and invasion; For in vivo experiments, nude BALB/c mice were used for detecting subcutaneous tumorigenesis and intraperitoneal implantation. Results：We found STEAP1 was overexpressed in gastric cancer tissues and cell lines. Single factor and Cox analyses showed that STEAP1 gene expression level correlated with poor prognosis. Upregulation of STEAP1 increased cell proliferation, migration, and invasion, which decreased after STEAP1 was knocked down. These changes were achieved via the activation of the AKT/FoxO1 pathway and epithelial-mesenchymal transformation (EMT). The in vivo animal experiments showed that STEAP1 knock down, resulted in a decrease in the subcutaneous tumor and peritoneal tumor formation.Conclusions：STEAP1 was overexpressed in gastric cancer and closely connected with OS. STEAP1 can regulate the cell cycle via the Akt/FoxO1 pathway to influence cell proliferation. STEAP1 may affect cell migration and invasion via EMT induction.
Costs and Cost-Effectiveness of HIV Counselling and Testing Modalities in Southern Mozambique
Authors: Choo Jun Hao , Lopez-Varela Elisa , Fuente-Soro Laura , Augusto Orvalho , Sacoor Charfudin , Nhacolo Ariel , Wei Stanley , Naniche Denise , Thomas Ranjeeta , Sicuri Elisa 
Published: August 2020

Abstract
Objective: Despite the high HIV associated burden, Mozambique lacks data on HIV counselling and testing (HCT) costs. To help guide national HIV/AIDS programs, we estimated the cost per test for voluntary counselling and testing (VCT) from the patient’s perspective and the costs per person tested and per HIV-positive individual linked to care to the healthcare provider for VCT, provider-initiated counselling and testing (PICT) and home-based testing (HBT). We also assessed the cost-effectiveness of these strategies for linking patients to care.Methods: Data from a cohort study conducted in the Manhiça District were used to derive costs and linkage-to-care outcomes of the three HCT strategies. A decision tree was used to model HCT costs according to the likelihood of HCT linking individuals to care and to obtain the incremental cost-effectiveness ratios (ICERs) of PICT and HBT with VCT as the comparator. Sensitivity analyses were performed to assess robustness of base-case findings. Findings: Average and median VCT costs to the patient per individual tested were US$1.34 and US$1.08, respectively. Costs per individual tested were greatest for HBT (US$11.07), followed by VCT (US$7.79), and PICT (US$7.14). The costs per HIV-positive individual linked to care followed a similar trend. PICT was not cost-effective in comparison with VCT at a willingness-to-accept threshold of US$4.53, but only marginally given a corresponding base-case ICER of US$4.15, while HBT was dominated, with higher costs and lower impact than VCT. Base-case results for the comparison between PICT and VCT presented great uncertainty, whereas findings for HBT were robust.Conclusion: PICT and VCT are likely equally cost-effective in Manhiça. We recommend that VCT be offered as the predominant HCT strategy in Mozambique, but expansion of PICT could be considered in limited-resource areas. HBT without facilitated linkage or reduced costs is unlikely to be cost-effective.
Simultaneous stereotactic radiosurgery of multiple brain metastases using single isocenter dynamic conformal arc therapy: a prospective monocentric registry trial
Authors: Bodensohn Raphael , Kaempfel Anna-Lena , Fleischmann Daniel Felix , Hadi Indrawati , Hofmaier Jan , Garny Sylvia , Reiner Michael , Forbrig Robert , Corradini Stefanie , Thon Niklas , Belka Claus , Niyazi Maximilian 
Published: August 2020

Abstract
Background Single-isocenter dynamic conformal arc (SIDCA) therapy is an efficient way of delivering stereotactic radiosurgery (SRS) to multiple metastases simultaneously. This study reports on the safety and feasibility of SRS with SIDCA for patients with multiple brain metastases.Methods All patients who received SRS with this technique between November 2017 and June 2019 within a prospective registry trial, were included. The patients were irradiated using a VersaHD® linear accelerator (LINAC) from Elekta (Stockholm, Sweden). Follow-up was performed every three months, including a clinical and radiological examination with cranial magnetic resonance imaging (MRI). The data were analyzed using descriptive statistics and the Kaplan-Meier method.Results 65 patients with 254 lesions (range 2–12) were included in this analysis. Median beam on time was 23 minutes. The median follow-up at the time of analysis was 13 months (95% CI 11.1–14.9). Median overall survival and median progression-free survival was 15 months (95% CI 7.7–22.3) and 18 months (95% CI 11.1–24.9), respectively. Intracranial and local control after 6 months was 73.0% and 97.5%, respectively. During follow-up, CTCAE grade 1 adverse effects (AE) were experienced by 29 (44.6%) patients (18 of them therapy-related (27.7%)), CTCAE grade 2 AEs by 4 (6.2%) patients (one of them therapy-related (1.5%)) and CTCAE grade 3 by 3 patients (4.6%) (none of them therapy-related). 2 lesions (0.8%) in 2 patients (3.1%) were proven as radiation necrosis. Conclusions Simultaneous SRS using SIDCA seems to be a feasible and safe treatment for patients with multiple metastases.
A global framework for a systemic view of brain modeling
Authors: Alexandre Frédéric 
Published: August 2020

Abstract
Background: The brain is a complex system, due to the heterogeneity of its structure, the diversity of the functions in which it participates and to its reciprocal relationships with the body and the environment. Researchers in cognitive computational neuroscience generally focused on one specific task, lack this global view and a clear understanding of how their model is inserted in a global cognitive architecture. A systemic description of the brain is presented here, as a general framework where specific models in computational neuroscience can be integrated and associated with global information flows and cognitive functions. Results: In an enactive view, this framework integrates the fundamental organization of the brain in sensorimotor loops with the internal and the external worlds, answering four fundamental questions (what, why, where and how). Our survival-oriented definition of behavior gives a prominent role to pavlovian and instrumental conditioning, augmented during phylogeny by the specific contribution of other kinds of learning, related to semantic memory in the posterior cortex, episodic memory in the hippocampus and working memory in the frontal cortex. Conclusions: This framework highlights that responses can be prepared in different ways, from pavlovian reflexes and habitual behavior to deliberations for goal-directed planning and reasoning, and explains that these different kinds of responses coexist, collaborate and compete for the control of behavior. It also lays emphasis on the fact that cognition can be described as a dynamical system of interacting memories, some acting to provide information to others, to replace them when they are not efficient enough, or to help for their improvement. Describing the brain as an architecture of learning systems has also strong implications in Machine Learning. Our biologically informed view of pavlovian and instrumental conditioning can be very precious to revisit classical Reinforcement Learning and provide a basis to ensure really autonomous learning.
The semi-dwarfing gene Rht-dp from dwarf Polish wheat (Triticum polonicum L.) is the “Green Revolution” gene Rht-B1b
Authors: Chai Songyue , Yao Qin , Zhang Xu , Xiao Xue , Fan Xing , Zeng Jian , Sha Lina , Kang Houyang , Zhang Haiqin , Li Jun , Zhou Yonghong , Wang Yi 
Published: August 2020

Abstract
Background
The wheat dwarfing gene improves lodging resistance, and increases the grain number per spike and harvest index. Dwarf polish wheat (Triticum polonicum L., 2n = 4x = 28, AABB, DPW), initially collected from Tulufan, Xinjiang, China, carries a semi-dwarfing gene Rht-dp on chromosome 4BS. However, Rht-dp and its dwarfing mechanism are unknown.
Results
Homologous cloning and fine mapping revealed that Rht-dp is the ‘Green Revolution’ gene Rht-B1b. A haplotype analysis showed that Rht-B1b was only present in T. polonicum. Transcriptomic analysis of two pairs of near-isogenic lines (NILs) of DPW × TPW revealed 41 differentially expressed genes (DEGs) as potential dwarfism-related genes. Among them, 28 functionally annotated DEGs were classed into five sub-groups: hormone-related signalling transduction genes, transcription factor genes, cell wall structure-related genes, reactive oxygen-related genes, and nitrogen regulation-related genes.
Conclusions
These results indicated that Rht-dp is Rht-B1b, which regulates pathways related to hormones, reactive oxygen species, and nitrogen assimilation to modify the cell wall structure, and then limits cell wall loosening and inhibits cell elongation, thereby causing dwarfism in DPW.
Effect of Opium Consumption on Cardiovascular Diseases – A cross- sectional study based on data of Rafsanjan cohort study
Authors: khalili parvin , Ayoobi Fatemeh , Mohamadi Maryam , Jamalizadeh Ahmad , Vecchia Carlo La , Esmaeili-nadimi Ali 
Published: August 2020

Abstract
Background
There are differences of opinion about the beneficial or detrimental effects of opium consumption on cardiovascular diseases (CVDs). So, we aimed to study the association between opium use and CVDs.
Methods
We used data obtained from the Rafsanjan Cohort Study (RCS), as part of the prospective epidemiological research studies in IrAN (PERSIAN), with detailed, validated data on opium consumption and some other exposures. A total of 10,000 adults were enrolled in the study. Logistic regression models were used to assess the possible relationships of opium consumption with the prevalence of ischemic heart diseases (IHD) and myocardial infarction (MI).
Results
In this study, 9990 participants in the baseline phase of the Rafsanjan adult cohort study were included according to the completed questionnaire. Among all participants, IHD and MI patients have been reported 870 and 296 respectively. Opium consumption was found to be relatively high in the RCS participants, especially in men (men = 2150 and women = 228). Opium use was associated with an increased risk of IHD and MI diseases, with the adjusted odds ratios (95% CI) of 1.67 (1.35–2.07) and 1.84 (1.35–2.49), respectively. Also, dose-response increases were observed with the highest odds ratios in the 4th quartile for MI and 4th quartile for IHD (p-values for trend < 0.001). Increased risks were observed for the two main methods of opium consumption, i.e. oral and smoking, but oral administration had higher odds ratio.
Conclusions
Opium dependence is associated with increased risk of both IHD and MI diseases.
Glycerol promoted the anaerobic production of rhamnolipids by different Pseudomonas aeruginosa strains
Authors: Zhao Feng , Guo Chao , Cui Qingfeng 
Published: August 2020

Abstract
Background: Rhamnolipids is the most widely studied and applied biosurfactants. The anaerobic biosynthesis of rhamnolipids has important research and practical significance, such as meeting the in situ production of biosurfactant in anoxic environments and the foamless fermentation of biosurfactants. A few studies have reported the anaerobic biosynthesis of rhamnolipids from rare Pseudomonas aeruginosa strains. What did promote the anaerobic biosynthesis of rhamnolipids, the specificity of the rare strains or the effect of specific substrates? Here, anaerobic production of rhamnolipids by different P. aeruginosa strains was investigated using diverse substrates. The anaerobic biosynthesis mechanism of rhamnolipids were also discussed from the substrate point of view.Results: All P. aeruginosa strains anaerobically grew well using the tested substrates. But all P. aeruginosa strains anaerobically produced rhamnolipids only using substrates containing glycerol and nitrate. Fourier transform infrared (FTIR) spectra analysis confirmed the anaerobic production of rhamnolipids from all P. aeruginosa strains. All the anaerobically produced rhamnolipids decreased air-water surface tension from 72.6 mN/m to below 29.0 mN/m and emulsified crude oil with EI24 above 65%. Using crude glycerol as low-cost substrate, all P. aeruginosa strains can anaerobically grow and produce rhamnolipids to reduce the culture surface tension below 35 mN/m. The glycerol metabolic intermediate, 1, 2-propylene glycol, can also achieve the anaerobic production of rhamnolipids by all P. aeruginosa strains.Conclusions: Not the specificity of the rare P. aeruginosa strains but the effect of specific substrates promote the anaerobic biosynthesis of rhamnolipids by P. aeruginosa. Glycerol and nitrate are the excellent substrates for anaerobic production of rhamnolipids from all P. aeruginosa strains. Results indicated that glycerol metabolism involveed the anaerobic biosynthesis of rhamnolipids in P. aeruginosa. Results also showed the feasibility of using crude glycerol as low cost substrate to anaerobically biosynthesize rhamnolipids by P. aeruginosa.
Real-time metabolic heat-based specific growth rate soft sensor for monitoring and control of high molecular weight HA production by Streptococcus zooepidemicus.
Authors: Mohan Naresh , Pavan Satya Sai , Jayakumar Anjali , Rathinavelu Sivakumar , Sivaprakasam Senthilkumar 
Published: August 2020

Abstract
Background: Hyaluronic acid (HA) is an important mucopolysaccharide of higher molecular weight range and holds sheer economic interest. Its applications are widely acknowledged in rheumatoid arthritis treatment, tissue engineering, and cosmetics industries. This present investigation aims for the fed-batch production of high molecular weight range HA by application of real-time metabolic heat measurements.Results: Fed-batch strategies based on Feedforward (FF) and Feedback (FB) control was devised to improve the Molecular Weight (MW) of HA production by S. zooepidemicus. Metabolic heat measurements (Fermentation calorimetry) were modeled to decipher real-time specific growth rate, µest was looped to the PID circuit, envisaged to control µSP to their desired setpoint values 0.05 h-1, 0.1 h-1 and 0.15 h-1 respectively. The developed FB strategy established a robust control on maintaining the specific growth rate (µ) close to the µSP value with a minimal tracking error. Exponential feed rate carried out with a lowest µSP of 0.05 h-1 improved the MW of HA significantly to 2.98 MDa and 2.94 MDa for the FF and FB based control strategies respectively. An optimal HA titer of 4.73 g/L was achieved in a FF control strategy at µSP = 0.15 h-1. Biomass and Lactic acid (LA) concentrations were found to be concomitant with the increase in µSP from 0.05 h-1 to 0.15 h-1. Superior control of µ at low µSP value was observed to influence positively the HA polymerization attributing to improved MW and desired Polydispersity Index (PDI) of HA.Conclusions: This present investigation attempts to address the metabolic bottleneck in synthesis of high MW HA by S. zooepidemicus and illustrates the application of calorimetric fed-batch control of µ at a narrower range. PID control offers advantage over conventional fed-batch method to synthesize HA at an improved MW. Calorimetric signal based µ control by PID negates adverse effects due to the secretion of other metabolites albeit maintaining homeostasis.
Unplanned hospitalizations in patients with locoregionally advanced head and neck cancer treated with (chemo)radiotherapy with and without prophylactic percutaneous endoscopic gastrostomy
Authors: Bojaxhiu Beat , Shrestha Binaya K. , Luterbacher Pascal , Elicin Olgun , Shelan Mohamed , Macpherson Andrew J. S. , Heimgartner Benjamin , Giger Roland , Aebersold Daniel M. , Zaugg Kathrin 
Published: August 2020

Abstract
Background: Current studies about percutaneous endoscopic gastrostomy (PEG) tube placement report equivalent patient outcomes with prophylactic PEG tubes (pPEGs) versus common nutritional support. Unreported was if omitting a pPEG is associated with an increased risk of complications leading to a treatment-related unplanned hospitalization (TRUH).Methods: TRUHs were retrospectively analyzed in patients with advanced head and neck squamous cell carcinoma (n=310) undergoing (chemo)radiotherapy with (pPEG) or without PEG (nPEG).Results: In 88 patients (28%), TRUH was reported. One of the leading causes of TRUH in nPEG patients was inadequate oral intake (n = 16, 13%), and in pPEG patients, complications after PEG tube insertion (n=12, 10%). Risk factors for TRUH were poor performance status, tobacco use, and surgical procedures.Conclusions: Omitting pPEG tube placement may be feasible in compliant patients in good general condition. Patients aged >60 years with hypopharyngeal carcinoma, tobacco consumption, and poor performance status appear at risk of PEG tube-related complications leading to an unplanned hospitalization.
Kinematic Calibration of a 7R 6-DOF Robot With Non-spherical Wrist Using Laser Tracker
Authors: Wang Xuhao , Zhang Dawei , Zhao Chen , Guo Zhiyong , Wu Mengli , Meng Xiangzhi , Ma Li 
Published: August 2020

Abstract
In this paper, a kinematic calibration method is proposed to improve the accuracy of a 7R 6-DOF robot with non-spherical wrist, where the parameters identifiability analysis and model reduction are particularly addressed in the identification procedure. Firstly, the kinematic error model of the robot is constructed based on the modified DH (MDH) model. Secondly, in order to derive a minimal model which is more suitable for practical application, model reduction is implemented considering compensability and constraints of the parameters defined in the controller, and QR decomposition is utilized to determine the redundant parameters, which are then removed in practical parameter identification. Finally, by using a laser tracker as the measuring device, a two-step procedure for error parameter estimation is proposed: (1) estimation of the robot base location with respect to the measurement coordinate system; (2) fine estimation of the identifiable kinematic parameters according to the measurement data. The experiment on a 7R 6-DOF industrial painting robot is implemented, the results show that the proposed method can effectively improve the accuracy of the robot.
Postoperative Management of The Primary Single Intracranial Rosai-Dorfman Disease: Case Report and Literature Review
Authors: Liu Xiaowei , Xu Yangyang , Wu Yang , Wen Rong , Gao Yuan , Wang Wei 
Published: August 2020

Abstract
The isolated intracranial Rosai-Dorfman disease (RDD) is extremely rare. It remains unclear for the best management of the residual lesions. In this report, the authors describe a case of primary single intracranial RDD treated with Gamma knife radiosurgery after partial resection, review all the related literatures and summarize the postoperative management data, in order to provide useful therapeutic information.A 23-year-old male presented with a more than 10-month history of dizziness, blurred vision and weakness. Preoperative MR imaging revealed a giant lesion involving the left middle cranial fossa and extending to the left cavernous sinus. He underwent fronto-temporal craniotomy and eventually achieved partial resection of the lesion. Postoperative histopathological results suggested a diagnosis of intracranial RDD. The residual lesion was treated with Gamma knife radiosurgery about 1 month after surgery. The follow-up imaging showed an obvious decrease in the size of the residual lesion.We are the second to provide the detail parameters of gamma knife therapy, which may be a reference for clinical neurosurgeons. Compared with the firstly reported case, our patient with a longer follow-up time has different therapeutic dose. Based on our own experience and an updated literature review, adjuvant stereotactic radiosurgery may be a safe and effective treatment for primary single intracranial RDD patients with incomplete excision. Other adjuvant therapies can be as an option in refractory patients.