bluuebunny/crossref_metadata_2025_split huggingface dataset:
Charge-Balanced Electrical Stimulation Can Modulate Neural Precursor Cell Migration in the Presence of Endogenous Electric Fields in Mouse Brains
Authors: Iwasa Stephanie N. , Rashidi Abdolazim , Sefton Elana , Liu Nancy X. , Popovic Milos R. , Morshead Cindi M. 
Published: November 2019

AbstractElectric fields (EFs) can direct cell migration and are crucial during development and tissue repair. We previously reported neural precursor cells (NPCs) are electrosensitive cells that can undergo rapid and directed migration towards the cathode using charge-balanced electrical stimulationin vitro. Here, we investigate the ability of electrical stimulation to direct neural precursor migration in mouse brainsin vivo. To visualize migration, fluorescent adult murine neural precursors were transplanted onto the corpus callosum of adult male mice and intracortical platinum wire electrodes were implanted medial (cathode) and lateral (anode) to the injection site. We applied a charge-balanced biphasic monopolar stimulation waveform for three sessions per day, for 3 or 6 d. Irrespective of stimulation, the transplanted neural precursors had a propensity to migrate laterally along the corpus callosum, and applied stimulation affected that migration. Further investigation revealed an endogenous EF along the corpus callosum that correlated with the lateral migration, suggesting that the applied EF would need to overcome endogenous cues. There was no difference in transplanted cell differentiation and proliferation, or inflammatory cell numbers near the electrode leads and injection site comparing stimulated and implanted non-stimulated brains. Our results support that endogenous and applied EFs are important considerations for designing cell therapies for tissue repairin vivo.
Congenital hypogonadotropic hypogonadism/Kallmann syndrome is associated with statural gain in both men and women: a monocentric study
Authors: Maione Luigi , Pala Giovanna , Bouvattier Claire , Trabado Séverine , Papadakis Georgios , Chanson Philippe , Bouligand Jérôme , Pitteloud Nelly , Dwyer Andrew A , Maghnie Mohamad , Young Jacques 
Published: November 2019

Context
Congenital hypogonadotropic hypogonadism/Kallmann syndrome (CHH/KS) is a rare condition characterized by gonadotropin deficiency and pubertal failure. Adult height (AH) in patients with CHH/KS has not been well studied.

Objective
To assess AH in a large cohort of patients with CHH/KS.

Patients
A total of 219 patients (165 males, 54 females). Parents and siblings were included.

Methods
AH was assessed in patients and family members. AH was compared to the general French population, mid parental target height (TH) and between patients and same-sex siblings. Delta height (∆H) was considered as the difference between AH and parental TH. ∆H was compared between patients and siblings, normosmic CHH and KS (CHH with anosmia/hyposmia), and according to underlying genetic defect. We examined the correlations between ∆H and age at diagnosis and therapeutically induced individual statural gain.

Results
Mean AH in men and women with CHH/KS was greater than that in the French general population. Patients of both sexes had AH > TH. Males with CHH/KS were significantly, albeit moderately, taller than their brothers. ∆H was higher in CHH/KS compared to unaffected siblings (+6.2 ± 7.2 cm vs +3.4 ± 5.2 cm, P < 0.0001). ∆H was positively correlated with age at diagnosis. Neither olfactory function (normosmic CHH vs KS) nor specific genetic cause impacted ∆H. Individual growth during replacement therapy inversely correlated with the age at initiation of hormonal treatment (P < 0.0001).

Conclusions
CHH/KS is associated with higher AH compared to the general population and mid-parental TH. Greater height in CHH/KS than siblings indicates that those differences are in part independent of an intergenerational effect.
A Genetic Screen for Genes That Impact Peroxisomes in Drosophila Identifies Candidate Genes for Human Disease
Authors: Graves Hillary K , Jangam Sharayu , Tan Kai Li , Pignata Antonella , Seto Elaine S , Yamamoto Shinya , Wangler Michael F 
Published: November 2019

Abstract
Peroxisomes are subcellular organelles that are essential for proper function of eukaryotic cells. In addition to being the sites of a variety of oxidative reactions, they are crucial regulators of lipid metabolism. Peroxisome loss or dysfunction leads to multi-system diseases in humans that strongly affect the nervous system. In order to identify previously unidentified genes and mechanisms that impact peroxisomes, we conducted a genetic screen on a collection of lethal mutations on the X chromosome in Drosophila. Using the number, size and morphology of GFP tagged peroxisomes as a readout, we screened for mutations that altered peroxisomes based on clonal analysis and confocal microscopy. From this screen, we identified eighteen genes that cause increases in peroxisome number or altered morphology when mutated. We examined the human homologs of these genes and found that they are involved in a diverse array of cellular processes. Interestingly, the human homologs from the X-chromosome collection are under selective constraint in human populations and are good candidate genes particularly for dominant genetic disease. This in vivo screening approach for peroxisome defects allows identification of novel genes that impact peroxisomes in vivo in a multicellular organism and is a valuable platform to discover genes potentially involved in dominant disease that could affect peroxisomes.
COMPOSICIÓN CORPORAL, PERFIL LIPÍDICO Y APTITUD FÍSICA EN MUJERES ADOLESCENTES EN MÉXICO
Authors: Hernández-Murúa José Aldo , Llamas-Hernández Baldomero , Salazar C Ciria Margarita , Gómez-Figueroa Julio Alejandro , Acuña-Cordova Cesar Augusto , De Paz-Fernández Jose Antonio 
Published: November 2019

El objetivo de esta investigación fue determinar la composición corporal, el perfil de lípidos sanguíneos y aptitud física en mujeres adolescentes con y sin sobrepeso, y correlacionar cada variable con las demás. Se consideró un diseño transversal. Participaron 38 mujeres adolescentes con edades entre 14 y 19 años. Clasificadas como normopeso (n = 21) o sobrepeso (n = 17) según la gráfica de la Organización Mundial de la Salud mediante el IMC (kg/m²) en función del puntaje z para edades de 5 a 19 años (puntaje z: 0 a +1 DE = normopeso, +1 a +2 DE = sobrepeso). Se realizaron mediciones de composición corporal, perfil de lípidos sanguíneos (colesterol total, triglicéridos, cHDL, cLDL) y aptitud física (VO2pico y 1RM). Los resultados muestran que las adolescentes con normopeso fueron significativamente (p < 0.05) más bajas (M ± DE) en todas las variables de composición corporal que las mujeres adolescentes con sobrepeso. No se encontraron diferencias significativas en el VO2pico, 1RM ni en el perfil de lípidos sanguíneos. En conclusión, las mujeres adolescentes con sobrepeso presentan mayores niveles de composición y grasa corporal pero estos niveles superiores no parecen afectar los niveles de lípidos sanguíneos. Se encontró una asociación entre los niveles de aptitud física (VO2pico) y la composición corporal (% grasa, pliegues cutáneos). Se sugieren otros estudios para buscar la asociación entre los niveles de VO2pico y grasa corporal.
Cultural Policies. The First Decade of the La Fontaine Literature Society (1920–1930)
Authors: Varga Ildikó P. 
Published: November 2019

The La Fontaine Literature Society was founded in 1920 in Budapest. Its task was to promote the world literature in Hungary and to make Hungarian literature better known abroad.
One of the founders was Béla Vikár, who also translated the Fables of Jean La Fontaine into Hungarian. In my paper I investigate his correspondence between 1920 and 30 and the deed of foundation of the La Fontaine Society. My aim is to describe the place and the role of Finnish and Estonian literatures in the Society's work.
The effects of onion skin powder on the quality of cooked chicken meat patties during refrigerated storage
Authors: Kurt Ş. , Ceylan H. G. , Akkoç A. 
Published: November 2019

In this study, the effects of onion skin powder (OSP) (0, 1.5, 3.0, and 6%) on some chemical and physical properties of cooked chicken meat patties during refrigerated storage (30 days, 4±1 °C) were investigated. For this purpose, moisture, fat, pH, free fatty acid (FFA), and thiobarbituric acid (TBA) analyses in the raw meat patties were also carried out. In addition, the chemical (moisture, fat), technological (diameter reduction, cooking yield), and sensory properties of cooked chicken patties were examined on the first day of storage. During storage, pH, colour, FFA, and TBA analyses were performed.There were significant changes in the physical, chemical, technological, and sensory properties of chicken patties with OSP addition. The moisture, pH, and TBA values of samples decreased by incorporated OSP. Moreover, the use of OSP improved technological parameters of patties. However, the addition of OSP resulted in a darker colour in patties. In conclusion, OSP could be used in chicken meat patties to improve their quality properties.
Migrations and symbolic transit to air citizenship/Las migraciones y el tránsito simbólico hacia ciudadanías aéreas
Authors: Hernández Carmona Luis Javier 
Published: November 2019

RESUMEN En este trabajo se abordan las migraciones desde el punto de vista ontosemiótico, e intenta dar cuenta de las prácticas discursivas establecidas a través del tránsito simbólico hacia la construcción de ciudadanías aéreas como formas de representar la patemia que busca resarcir los vínculos de los sujetos entre los espacios originarios y las realidades trasplantadas. Para de esta forma desarrollar un planteamiento fundamentado no sólo en la movilidad física, sino en la articulación de metáforas y alegorías dentro de la resignificación de acontecimientos a través de lógicas de sentido patemizadas que desbordan lo crasamente lexical, e instauran una cosmovisión desde los imaginarios y su implicación en los discursos culturales. MIGRATIONS AND SYMBOLIC TRANSIT TO AIR CITIZENSHIP Abstract Migrations are discussed from the point of view ontosemiotic in this work, and it tries to give an account of the discursive practices established through the symbolic transit towards the construction of aerial citizenships as ways to represent the patemia seeking compensate the links of the subjects between the originating spaces and transplanted realities. For in this way develop an approach based not only on physical mobility, but in the articulation of metaphors and allegories within the resignification of events through logic of sense patemizadas that overflow the grossly lexical (e) they found a worldview from the imaginary and their involvement in the cultural discourses.Key words: imaginary, nostalgia, citizenship, patemia, transit. MIGRAÇÕES E TRÂNSITO SIMBÓLICO AOS CIDADÃOS AÉREOSRESUMO Este trabalho trata das migrações desde o ponto de vista ontosemiótico e busca dar conta das práticas discursivas estabelecidas pelo trânsito simbólico para a construção de cidadanias aéreas como formas de representar a patemia que busca compensar os vínculos dos sujeitos entre os espaços originais e realidades transplantadas. A fim de desenvolver uma abordagem baseada não apenas na mobilidade física, mas na articulação de metáforas e alegorias dentro da ressignificação de eventos através da lógica de patemizadas de sentido que transbordam o léxico crasso, e estabelecer uma visão de mundo a partir do imaginário e seu envolvimento em discursos culturais.Palavras-chave: imaginário, nostalgia, cidadania, patemia, trânsito.
Executive functions in schoolchildren aged 7 to 14 years with Low academic performance of educational institution/Funciones ejecutivas en escolares de 7 a 14 años de edad con bajo rendimiento académico en una institución educativa
Authors: Londoño León Paolo , Becerra-García Juan Antonio , Arias-Castro Cristian Camilo , Martínez-Bustos Plutarco Segundo 
Published: November 2019

Una de las principales preocupaciones de los profesores tiene que ver con el bajo rendimiento académico de los estudiantes. Lograr identificar el origen de la dificultad es todo un reto por eso se analizan las funciones ejecutivas (FE) por ser ellas de gran utilidad y uso para el aprendizaje. Este estudio contó con una muestra de 30 estudiantes escolarizados con bajo rendimiento académico, a los cuales se les evaluaron las FE a través de las pruebas TMT, test de fluidez verbal y test de tarjetas de Wisconsin. El bajo rendimiento académico se identificó a través de la historia académica. Es un estudio de enfoque cuantitativo, tipo descriptivo – transversal y correlacional. La mayoría de los participantes tuvieron un desempeño por debajo de la media y desviación estándar en el test de cartas de Wisconsin en la medida errores, así como en el FAS fonológico y en el TMT parte B con algunas diferencias no significativas identificadas por edades en otras medidas de las pruebas. Existe relación estadísticamente significativa entre el automonitoreo y autocorrección y las FE: diseño de planes y programas y resolución eficiente de problemas en los participantes. También hay relación entre la edad y el desarrollo de la capacidad de resolución eficiente de problemas, así mismo con la capacidad de automonitoreo y autocorrección. A mayor diseño de planes y programas, mayor resolución eficiente de problemas. Existe necesidad de estudiar otras variables que incidan en el rendimiento académico de escolares. La rehabilitación cognitiva de las FE, ayudará en el logro escolar.
The tradition of the procuress in Memories of my sad whores
Authors: Motato Camelo Hernando 
Published: November 2019

The purpose of this essay is to trace the way in which the character of Spanish brothel life is treated during the Middle Ages and Renaissance. This character defines his love affairs, seduces and attracts the young women to have love encounters with their suitors through deceits and love potions. García Márquez adopts these literary traditions in the early 20th century in Barranquilla and enriches them with characters such as the procuress and maid Delgadina.
Akut Koroner Sendromlu Hastalarda Çok Damar Hastalığı ile Kardiyovasküler Risk Faktörleri Arasındaki İlişki
Authors: ALP Çağlar , KARADENİZ Muhammed , SARAK Taner , DEMİR Vahit 
Published: November 2019

Amaç: Akut koroner sendrom olgularında kardiyovasküler
risk faktörleriyle, ciddi darlığa neden olan koroner arter sayısı arasındaki
ilişki değerlendirildi.

Yöntemler: Bu çalışma retrospektif olarak dizayn edildi. 2016–2018
tarihleri arasında akut koroner sendrom sebebiyle koroner anjiografi yapılan
904 hasta çalışmaya dahil edildi. Ciddi koroner arter darlığı olmayan ve koroner
operasyon geçiren hastalar çalışma dışı bırakıldı. Hastalar kritik koroner
arter darlıklarına göre tek damar hastalığı (TDH) ve çok damar hastalığı (ÇDH) olacak
şekilde iki gruba ayrıldı. ÇDH ile TDH olanlar klasik kardiyovasküler risk
faktörleri açısından karşılaştırıldı.

Bulgular: Hastaların 544’ünde (%60) ÇDH 365’inde (%40) TDH
saptandı. ÇDH olan grupta yaş, hipertansiyon ve diyabet mellitus istatistiksel
olarak daha fazla saptandı (sırasıyla p&lt;0.001, p=0.003, p=0.005). TDH olan
grupta ise erkek cinsiyet, aile öyküsü ve sigara içiciliği istatistiksel olarak
daha fazla saptandı (sırasıyla p=0.006, p&lt;0.001, p&lt;0.001).

Sonuç: Diyabet ve hipertansiyon ÇDH grubunda yüksek saptanırken aile
öyküsü ve sigara içiciliği TDH grubunda yüksek saptandı. Akut koroner sendrom hastalarında bu risk faktörlerin
göz önünde bulundurulması önemlidir.
Poultry and cattle manure effects on sunflower performance, grain yield and selected soil properties in Limpopo Province, South Africa
Authors: Mokgolo Matome J. , Mzezewa Jestino , Odhiambo Jude J.O. 
Published: November 2019

The application of organic manures as alternatives to reduce the use of mineral fertilisers is considered a good agricultural practice for smallholder farmers. However, the effect of organic manure on soil properties and crop yield depends upon its application rate and its chemical composition. A field experiment was carried out during the 2013/2014 and 2014/2015 seasons at the University of Venda experimental farm (Limpopo Province, South Africa) to determine the effect of three organic manures (cattle, poultry and their 1:1 combination, 20 t/ha) on sunflower (Helianthus annuus L.) performance, grain yield and selected soil properties under rainfed conditions. Poultry manure produced the highest final infiltration rate and cumulative infiltration followed by cattle manure, their combination and the control in that order. Total nitrogen, calcium, and zinc were significantly different between treatments in the first season while potassium, sodium, and zinc were significantly different in the second season. Manure combination and poultry manure produced the highest organic carbon and available phosphorus, respectively, in both seasons compared to other treatments. Organic manure application had a significant (p<0.05) effect on dry matter, plant height and stem girth at all growth stages in the second cropping season but only in the flower bud stage for both parameters in the first season. Manure application in the second season resulted in an increase in the grain yield compared to the first season, except after application of poultry manure whereafter the grain yield decreased significantly by 168% from the first cropping season. The application of organic manure had a significant effect on sunflower grain yield, dry matter, head dry matter, plant height and stem girth throughout all growing stages in the second cropping season with poultry manure producing the best values.
Significance:

Application of the three organic manures served as a good source of organic amendments for improvement of plant nutrients and selected soil properties.
Based on the results of this study, poultry manure can be recommended as the first choice among the manure used for local smallholder farmers, especially under evenly distributed rainfall.
ANALISA PENGARUH KUALITAS LAYANAN TERHADAP KEPUASAN PELANGGAN MENGINAP DI EMPAT VIRTUAL HOTEL OPERATOR DI SURABAYA
Authors: Gunawan Edwin , Sebastian Gabriel Octavianus , Harianto Agung 
Published: November 2019

ABSTRAKPenelitian ini dilakukan untuk menganalisis pengaruh kualitas layanan melalui variabel tangible, reliability, responsiveness, assurance dan empathy terhadap kepuasan konsumen yang menginap di Virtual Hotel Operator di Surabaya. Jenis penelitian ini adalah penelitian kausal kuantitatif menggunakan teknik analisa deskriptif dan regresi linier berganda. Hasil penelitian menunjukan bahwa kelima variabel secara simultan memiliki pengaruh yang positif dan signifikan terhadap kepuasan konsumen tetapi secara parsial, hanya variabel tangible, assurance dan empathy yang berpengaruh positif dan signifikan terhadap kepuasan konsumen. Variabel empathy menjadi variabel yang paling dominan dalam mempengaruhi kepuasan konsumen. Kata Kunci: Kepuasan Konsumen, Kualitas Layanan, Virtual Hotel Operator ANALYSIS OF SERVICE QUALITY TO CUSTOMER SATISFACTION STAYING AT VIRTUAL HOTEL OPERATOR SURABAYA ABSTRACTThe research was conducted to analyze the influnced of service quality through 5 variables which were tangible, reliability, responsiveness, assurance and empathy to customer satisfaction staying at Virtual Hotel Operator in Surabaya. The thpe of research is a quantitative causal research, by using descriptive analysis techniques and multiple linear regression. The results showed that all 5 variables simultaneously had a positive and significant effect on customer satisfaction, but partially, only tangible, assurance and empathy that had positive and significant effect on customer satisfaction. Empathy was the most dominant variable that influence customer satisfaction.Keyword: Customes Satisfaction, Service Quality, Virtual Hotel Operator
Design Developer Competition in Stockholm
Authors: Rönn Magnus 
Published: November 2019

This case study examines a developer competition held in Stockholm in 2013-2014 organized by the municipal government. The objective was to develop good and affordable housing for young citizens. Fifteen design teams took part in the competition. The jury compared two different proposals in the final evaluation: one with separate rooms linked to a collective space and one that consisted of small housing units. This sorting of design proposals in two main categories had a major impact on the judging in the competition. The jury declared the solution with small housing units as the winner, which reinforced the overall category as the appropriate direction for the design solution.
There are three typical key players in the competition: the organizer, the jury, and the design teams. The organizer was responsible for the objective and terms presented in the brief. The jury was responsible to assign a winner. Architects, builders, and developers responded to the task by organizing design-teams and producing architectural design solutions. They had to understand affordability as both cost (rent level) and architectural design (area-effective apartments).
The competition in Stockholm was investigated in a case study. Research data was collected from archives and through questionnaires answered by jury members and design teams. Methods used for analyzing documents and design solutions were close reading and architectural criticism.
Twenty-two architectural students studied the competition in a course. In this case study, I compare how the professional jury evaluated the proposals to jury reports from the students focusing on innovative solutions. The professional jury and the student juries used the same criteria for judging but appointed different winners. The students preferred the solution with collective living. One explanation for this difference can be found in the structure of the evaluation process.
The results of the study can be summarized in ten conclusions that deal with sorting and ranking of design proposals, criteria for judging, marketing of the competition, uncertainty and knowledge, motives for competing, innovation, and the competition as a tool for the political ambition of the public organizers. The result produced new knowledge. There are few studies focusing on developer competition as the production of design proposals and architectural quality.
Kreatywność projektantów zabawek zatrudnionych w spółdzielniach pracy w okresie PRL a czynniki ją ograniczające
Authors: Wieczorek Maria 
Published: November 2019

<p>W 1980 roku Janos Kornai opublikował pracę pt. „Gospodarka niedoboru”. Zdefiniował w ten sposób centralnie sterowaną gospodarkę Komunistyczną. Także w Polskiej Rzeczpospolitej Ludowej, kraju, w którym po II wojnie światowej władzę przejęła Polska<br />Zjednoczona Partia Robotnicza, brakowało wielu artykułów. Choć osobom żyjącym w czasach PRL w pamięci zapisał się głównie brak podstawowych artykułów spożywczych czy przemysłowych,<br />także ilość (i jakość) zabawek pozostawiała wiele do życzenia. Brakowało nie tylko tkanin, surowców i innych materiałów potrzebnych do produkcji zabawek, ale także specjalistycznych maszyn i innych urządzeń. Nie było także odpowiedniej ilości wykwalifikowanych pracowników, m.in. z tego powodu w okresie PRL-u nie każde przedsiębiorstwo produkujące<br />zabawki zatrudniało własnych projektantów. Mimo to w spółdzielniach pracy (bo to właśnie stamtąd pochodziła większość lalek czy<br />samochodzików, które można było kupić w sklepach czy kioskach ruchu) powstawało wiele ciekawych wzorów. W artykule opisałam zarówno działalność zakładowych wzorcowni i prototypowni,<br />jak i przywołałam nazwiska projektantów pracujących w przemyśle zabawkarskim.</p>