bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promising potential of [177Lu]Lu-DOTA-folate to enhance tumor response to immunotherapy—a preclinical study using a syngeneic breast cancer model
Authors: Guzik Patrycja , Siwowska Klaudia , Fang Hsin-Yu , Cohrs Susan , Bernhardt Peter , Schibli Roger , Müller Cristina 
Published: October 2020

AbstractPurposeIt was previously demonstrated that radiation effects can enhance the therapy outcome of immune checkpoint inhibitors. In this study, a syngeneic breast tumor mouse model was used to investigate the effect of [177Lu]Lu-DOTA-folate as an immune stimulus to enhance anti-CTLA-4 immunotherapy.MethodsIn vitro and in vivo studies were performed to characterize NF9006 breast tumor cells with regard to folate receptor (FR) expression and the possibility of tumor targeting using [177Lu]Lu-DOTA-folate. A preclinical therapy study was performed over 70 days with NF9006 tumor-bearing mice that received vehicle only (group A); [177Lu]Lu-DOTA-folate (5 MBq; 3.5 Gy absorbed tumor dose; group B); anti-CTLA-4 antibody (3 × 200 μg; group C), or both agents (group D). The mice were monitored regarding tumor growth over time and signs indicating adverse events of the treatment.Results[177Lu]Lu-DOTA-folate bound specifically to NF9006 tumor cells and tissue in vitro and accumulated in NF9006 tumors in vivo. The treatment with [177Lu]Lu-DOTA-folate or an anti-CTLA-4 antibody had only a minor effect on NF9006 tumor growth and did not substantially increase the median survival time of mice (23 day and 19 days, respectively) as compared with untreated controls (12 days). [177Lu]Lu-DOTA-folate sensitized, however, the tumors to anti-CTLA-4 immunotherapy, which became obvious by reduced tumor growth and, hence, a significantly improved median survival time of mice (> 70 days). No obvious signs of adverse effects were observed in treated mice as compared with untreated controls.ConclusionApplication of [177Lu]Lu-DOTA-folate had a positive effect on the therapy outcome of anti-CTLA-4 immunotherapy. The results of this study may open new perspectives for future clinical translation of folate radioconjugates.
Passive Versus Active Intra‐Abdominal Drainage Following Pancreaticoduodenectomy: A Retrospective Study Using The American College of Surgeons NSQIP Database
Authors: Lemke Madeline , Park Lily , Balaa Fady K. , Martel Guillaume , Khalil Jad Abou , Bertens Kimberly A. 
Published: October 2020

AbstractBackgroundProphylactic drainage following pancreaticoduodenectomy (PD) reduces morbidity and mortality. Little evidence exists to advise on whether passive gravity (PG) or active suction (AS) drainage systems result in superior outcomes. This study examines the relationship between drainage system and morbidity following PD.MethodsAll patients undergoing elective PD with an operatively placed drain in the 2016 ACS‐NSQIP database were included. Pre‐ and intra‐operative factors were examined. Multivariable logistic regression and coarsened exact matching (CEM) were used to assess for an association between drainage system (PG vs. AS) and morbidity. The primary outcome was postoperative pancreatic fistula (POPF).ResultsIn total, 3430 patients were included: 563 (16.4%) with PG and 2867 (83.6%) with AS drainage system. On multivariable regression, 1787 patients were included. Drainage type was not associated with POPF, surgical site infection, delayed gastric emptying, or re‐operation. AS drainage was protective against percutaneous drain insertion (OR 0.65, 95% CI 0.44–0.96, p = 0.033). In the CEM cohort (n = 268), superficial SSI was higher in the AS group (0.8% vs. 6.0%, p = 0.036). There was a trend toward higher rates of composite total SSI (PG 15.7%, AS 23.9%, p = 0.092) and organ space SSI (PG 14.2%, AS 20.2%, p = 0.195) in the AS group; this did not demonstrate statistical significance.ConclusionsThe findings of this study suggest that AS drainage is protective against percutaneous drain insertion, but may be associated with increased risk of SSI. There was no relation between drainage type and POPF. A prospective, randomized controlled trial is warranted to further explore these findings.
The Dinaric Mountains versus the Western Carpathians: Is structural heterogeneity similar in close-to-primeval Abies–Picea–Fagus forests?
Authors: Paluch J. , Keren S. , Govedar Z. 
Published: October 2020

AbstractIn this study, we analysed patterns of spatial variation in the basal area of live and dead trees and structural complexity in close-to-primeval forests in the Dinaric Mts. The results were compared with an analogous study conducted in the Western Carpathians. The research was carried out in the Janj, Lom and Perucića forest reserves (Bosnia and Herzegovina) in mixed-species stands of silver fir Abies alba Mill., European beech Fagus sylvatica L. and Norway spruce Picea abies (L.) H. Karst. In the core zones of the reserves, concentric sample plots (154 and 708 m2) were set in a regular 20 × 20 m grid covering approximately 10 ha. The analyses revealed varying distribution patterns of live canopy trees, suggesting that these characteristics may fluctuate to some extent at the regional level. At the spatial scale of 708 m2, attractive associations between dead canopy trees were found, but this tendency disappeared with increasing area. Although stands in the Dinaric Mts. are characterized by an almost twofold greater biomass accumulation compared to those from the Western Carpathians, the study revealed analogous bell-shaped distributions of stand basal areas of live trees and a very similar trend of decreasing variation in stand basal area and structural heterogeneity with increasing spatial scale. Nonetheless, the higher growing stocks, lower ratios of dead to live tree basal area and lower proportion of homogeneous structure types found in the Dinaric Mts. may suggest a less severe disturbance history over recent decades in this region compared to the Western Carpathians.
Logic-based technologies for multi-agent systems: a systematic literature review
Authors: Calegari Roberta , Ciatto Giovanni , Mascardi Viviana , Omicini Andrea 
Published: October 2020

AbstractPrecisely when the success of artificial intelligence (AI) sub-symbolic techniques makes them be identified with the whole AI by many non-computer-scientists and non-technical media, symbolic approaches are getting more and more attention as those that could make AI amenable to human understanding. Given the recurring cycles in the AI history, we expect that a revamp of technologies often tagged as “classical AI”—in particular,logic-basedones—will take place in the next few years. On the other hand, agents andmulti-agent systems(MAS) have been at the core of the design of intelligent systems since their very beginning, and their long-term connection withlogic-based technologies, which characterised their early days, might open new ways to engineerexplainable intelligent systems. This is why understanding the current status oflogic-based technologies for MASis nowadays of paramount importance. Accordingly, this paper aims at providing a comprehensive view of those technologies by making them the subject of asystematic literature review(SLR). The resulting technologies are discussed and evaluated from two different perspectives: the MAS and the logic-based ones.
Introduction to symposium ‘Reimagining land: materiality, affect and the uneven trajectories of land transformation’
Authors: Sippel Sarah Ruth , Visser Oane 
Published: October 2020

AbstractOver the past decade land has again moved to the centre of resource conflicts, agrarian struggles, and competing visions over the future of food and farming. This renewed interest in land necessitates asking the seemingly simple, but pertinent, question ‘whatisland?’ To reach a more profound understanding of the uniqueness of land, and what distinguishes land from other resources, this symposium suggests the notion of ‘land imaginaries’ as a crucial lens in the study of current land transformations. Political-economy, and the particular economic, financial, or political interests of various actors involved in land projects do not directly result in, or translate into, outcomes, such as dispossession and enclosure, increased commodification, financialization, and assetization, or mobilization and resistance. All these processes are informed by different imaginaries of land—the underlying understandings, views, and visions of what land is, can, and should be—and associated visions, hopes, and dreams regarding land. Drawing on a variety of case studies from across the world, crossing Global North/South and East/West, and including contemporary and historical instances of land transformation, this symposium addresses the multifaceted ways in which implicit, explicit, and emergent understandings of land shape current land transformations.
The prognostic significance of interferon-stimulated gene 15 (ISG15) in invasive breast cancer
Authors: Kariri Yousif A. , Alsaleem Mansour , Joseph Chitra , Alsaeed Sami , Aljohani Abrar , Shiino Sho , Mohammed Omar J. , Toss Michael S. , Green Andrew R. , Rakha Emad A. 
Published: October 2020

Abstract
Background
Lymphovascular invasion (LVI) is a prognostic factor in early-stage invasive breast cancer (BC). Through bioinformatics, data analyses of multiple BC cohorts revealed the positive association between interferon-stimulated gene 15 (ISG15) LVI status. Thus, we explored the prognostic significance of ISG15 in BC.

Methods
The prognostic significance of ISG15 mRNA was assessed in METABRIC (n = 1980), TCGA (n = 854) and Kaplan–Meier Plotter (n = 3951). ISG15 protein was evaluated using immunohistochemistry (n = 859) in early-stage invasive BC patients with long-term follow-up. The associations between ISG15 expression and clinicopathological features, expression of immune cell markers and patient outcome data were evaluated.

Results
High mRNA and protein ISG15 expression were associated with LVI, higher histological grade, larger tumour size, hormonal receptor negativity, HER2 positivity, p53 and Ki67. High ISG15 protein expression was associated with HER2-enriched BC subtypes and immune markers (CD8, FOXP3 and CD68). High ISG15 mRNA and ISG15 expressions were associated with poor patient outcome. Cox proportional multivariate analysis revealed that the elevated ISG15 expression was an independent prognostic factor of shorter BC-specific survival.

Conclusion
This study provides evidence for the role of ISG15 in LVI development and BC prognosis. Further functional studies in BC are warranted to evaluate the therapeutic potential of ISG15.
Disease-free and overall survival after neoadjuvant chemotherapy in breast cancer: breast-conserving surgery compared to mastectomy in a large single-centre cohort study
Authors: Simons Janine M. , Jacobs Julien G. , Roijers Joost P. , Beek Maarten A. , Boonman-de Winter Leandra J. M. , Rijken Arjen M. , Gobardhan Paul D. , Wijsman Jan H. , Tetteroo Eric , Heijns Joan B. , Yick C. Y. , Luiten Ernest J. T. 
Published: October 2020

Abstract
Purpose
The extended role of breast-conserving surgery (BCS) in the neoadjuvant setting may raise concerns on the oncologic safety of BCS compared to mastectomy. This study compared long-term outcomes after neoadjuvant chemotherapy (NAC) between patients treated with BCS and mastectomy.

Methods
All breast cancer patients treated with NAC from 2008 until 2017 at the Amphia Hospital (the Netherlands) were included. Disease-free and overall survival were compared between BCS and mastectomy with survival functions. Multivariable Cox proportional hazard regression was performed to determine prognostic variables for disease-free survival.

Results
561 of 612 patients treated with NAC were eligible: 362 (64.5%) with BCS and 199 (35.5%) with mastectomy. Median follow-up was 6.8 years (0.9–11.9). Mastectomy patients had larger tumours and more frequently node-positive or lobular cancer. Unadjusted five-year disease-free survival was 90.9% for BCS versus 82.9% for mastectomy (p = .004). Unadjusted five-year overall survival was 95.3% and 85.9% (p < .001), respectively. In multivariable analysis, clinical T4 (cT4) (HR 3.336, 95% CI 1.214–9.165, p = .019) and triple negative disease (HR 5.946, 95% CI 2.703–13.081, p < .001) were negative predictors and pathologic complete response of the breast (HR 0.467, 95% CI 0.238–0.918, p = .027) and axilla (HR 0.332, 95% CI 0.193–0.572, p = .001) were positive predictors for disease-free survival. Mastectomy versus BCS was not a significant predictor for disease-free survival when adjusted for the former variables (unadjusted HR 2.13 (95%CI: 1.4–3.24), adjusted HR 1.31 (95%CI: 0.81–2.13)). In the BCS group, disease-free and overall survival did not differ significantly between cT1, cT2 or cT3 tumours.

Conclusion
BCS does not impair disease-free and overall survival in patients treated with NAC. Tumour biology and treatment response are significant prognostic indicators.
The Properties of Powers: Didactic Contract and Gender Gap
Authors: Ferretti Federica , Giberti Chiara 
Published: October 2020

AbstractNational and international large-scale assessments of mathematics show that, in most nations, males achieve better results than females and Italy is one of the countries with a greater gap. Many research studies in mathematics education have analysed this issue, using both quantitative and qualitative methods to understand the sources and characteristics of this gap. This study focuses on a specific Grade 10 task that requires algebraic manipulations of powers with the same base. Item-level analysis enables the study of gender differences on specific content, before using the lenses of mathematics education theories to interpret macro-phenomena emergeing from standardized assessment results. The quantitative analysis, carried out using the Rasch statistical model, highlights a gender gap in favour of males in this task and, furthermore, a variance in choices of incorrect options between males and females; the interviews conducted provide a key to understanding this phenomenon in terms of didactic contract.
Theory and the breadth-and-depth method of analysing large amounts of qualitative data: a research note
Authors: Edwards Rosalind , Davidson Emma , Jamieson Lynn , Weller Susie 
Published: October 2020

AbstractThis research note builds on a previously published discussion of the ‘breadth-and-depth’ method for working with extensive amounts of secondary qualitative data, to consider the way that theory can be used and developed as part of this method. We illustrate potential deductive, inductive, and abductive logics of the relationship between theory and data that can be pursued using the method, but note that in reality research analysis rarely proceeds along such clear categorical lines. Rather, qualitative researchers are more likely to pursue a flexible retroductive logic and analytic practice that the breadth-and-depth method also can accommodate.
The effects of different cooking modes on the 137Cs, 40K, and total K content in Boletus edulis (King Bolete) mushrooms
Authors: Saba Martyna , Falandysz Jerzy 
Published: October 2020

AbstractThis study aimed to get an insight into the effects of household processing on the leaching behaviour of 137Cs and 40K from fresh, frozen and dried Boletus edulis (King Bolete) mushrooms. Three processes were investigated—blanching, blanching and pickling, and drying followed by grinding and soaking. The activity concentrations of 137Cs and 40K in the fresh unprocessed mushrooms were 270 Bq kg−1 dry biomass (27 Bq kg−1 whole weight) and 590 Bq kg−1 db (59 Bq kg−1 ww), respectively. Blanching of fresh mushrooms decreased 137Cs activity by 55%, and 40K activity by 34%, and blanching of deep-frozen mushrooms caused a reduction of 52% and 44% (db) (equivalent to whole weight reductions of 37% and 8.5%, and 67% and 22%, respectively). Blanching and pickling of fresh mushrooms decreased 137Cs activity by 83% and 40K activity by 87%, while blanching deep-frozen mushrooms resulted in decreases of 88% and 80% (db) (whole weight decreases of 77% and 81%, and by ~ 84% and 72%, respectively). This study confirms earlier reports that blanching of fresh or frozen mushrooms alone is not as efficient at removing 137Cs as blanching followed by pickling. The study also shows that the initial rate of fruiting body disintegration and pre-preparation (comparing fresh, deep-frozen, or dried and ground) can have an impact on the leaching rate of the water soluble fraction of metallic elements.
Patient Satisfaction for Telehealth Physical Therapy Services was Comparable to that of In-Person Services during the COVID-19 Pandemic
Authors: Eannucci Erica Fritz , Hazel Kayla , Grundstein M. Jake , Nguyen Joseph T. , Gallegro James 
Published: October 2020

Background The COVID-19 pandemic has transformed the practice of physical therapy (PT), from a model based on in-person delivery to one that includes telehealth. However, research is needed to assess value, patient satisfaction, and clinical outcomes in the delivery of telehealth PT. Purposes We sought to compare patient satisfaction with in-person and telehealth PT and to determine the factors—such as age, gender, or insurance payer—that contributed to patient satisfaction scores. Methods Patients between the ages of 18 and 90 years who received outpatient PT at our institution were texted a patient satisfaction survey. Surveys were sent to patients who received in-person PT from January 1 to May 8, 2020, and to patients who received telehealth PT from April 21 to May 8, 2020. Patients' age, gender, insurance payer, and written comments were also collected. Kruskal-Wallis tests were used to compare survey scores between groups. χ-squared tests were used to compare categorical patient characteristics between groups. Results In total, 12,345 surveys were sent out. We included completed surveys from 1147 patients in the analysis. Of these, 33% identified as male and 67% as female, mean age was 60.3 years, 58% had commercial insurance, 36% had Medicare, 3% had Medicaid, 2% had no-fault/worker's compensation, and 1% had international insurance. The question of satisfaction was answered by 1074 patients. No statistical difference in satisfaction was seen in age or gender groups. Satisfaction differed by insurance type, but when analysis excluded patients with international insurance, there was no difference between groups. In-person PT patients reported higher satisfaction in achieving treatment goals, as rated on a 1-to-5 scale (4.7 ± 0.6), than telehealth PT patients (4.6 ± 0.6), although it is unclear if this result is clinically meaningful. There was no significant difference in the remaining follow-up questions. Conclusion We found no overall difference in patient satisfaction between those receiving in-person PT and those receiving telehealth PT. This was true for initial and follow-up visits, with the exception of two categories: the “ability of scheduling an appointment” and “progress towards attaining your treatment goals.” However, the clinical significance of these two exceptions is questionable. Ongoing research is indicated to evaluate the efficacy of telehealth PT while identifying the best patients and conditions for use during non-crisis times. Future studies should determine the effect of telehealth PT on patient-reported outcome measures, function, and value.
The Refeeding Syndrome: a neglected but potentially serious condition for inpatients. A narrative review
Authors: Ponzo Valentina , Pellegrini Marianna , Cioffi Iolanda , Scaglione Luca , Bo Simona 
Published: October 2020

AbstractThe Refeeding Syndrome (RFS) is a potentially serious, but still overlooked condition, occurring in individuals who are rapidly fed after a period of severe undernourishment. RFS derives from an abnormal electrolyte and fluid shifts leading to many organ dysfunctions. Symptoms generally appear within 2–5 days of re-feeding and may be absent/mild or severe and life threating, depending on the pre-existing degree of malnutrition and comorbidities. The lack of a standard definition and the nonspecificity of the symptoms make both incidence estimate and diagnosis difficult. In 2020, the American Society for Parenteral and Enteral Nutrition (ASPEN) proposed a unifying definition for the RFS and its severity classification. The awareness of the condition is crucial for identifying patients at risk, preventing its occurrence, and improving the management. The objectives of this narrative review were to summarize the current knowledge and recommendations about the RFS and to provide useful tips to help physicians to recognize and prevent the syndrome.
Tool wear estimation in turning of Inconel 718 based on wavelet sensor signal analysis and machine learning paradigms
Authors: Segreto Tiziana , D’Addona Doriana , Teti Roberto 
Published: October 2020

AbstractIn the last years, hard-to-machine nickel-based alloys have been widely employed in the aerospace industry for their properties of high strength, excellent resistance to corrosion and oxidation, and long creep life at elevated temperatures. As the machinability of these materials is quite low due to high cutting forces, high temperature development and strong work hardening, during machining the cutting tool conditions tend to rapidly deteriorate. Thus, tool health monitoring systems are highly desired to improve tool life and increase productivity. This research work focuses on tool wear estimation during turning of Inconel 718 using wavelet packet transform (WPT) signal analysis and machine learning paradigms. A multiple sensor monitoring system, based on the detection of cutting force, acoustic emission and vibration acceleration signals, was employed during experimental turning trials. The detected sensor signals were subjected to WPT decomposition to extract diverse signal features. The most relevant features were then selected, using correlation measurements, in order to be utilized in artificial neural network based machine learning paradigms for tool wear estimation.
Iterative framework for image registration and partial volume correction in brain positron emission tomography
Authors: Matsubara Keisuke , Ibaraki Masanobu , Shidahara Miho , Kinoshita Toshibumi ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: October 2020

AbstractImprecise registration between positron emission tomography (PET) and anatomical magnetic resonance (MR) images is a critical source of error in MR imaging-guided partial volume correction (MR-PVC). Here, we propose a novel framework for image registration and partial volume correction, which we term PVC-optimized registration (PoR), to address imprecise registration. The PoR framework iterates PVC and registration between uncorrected PET and smoothed PV-corrected images to obtain precise registration. We applied PoR to the [11C]PiB PET data of 92 participants obtained from the Alzheimer’s Disease Neuroimaging Initiative database and compared the registration results, PV-corrected standardized uptake value (SUV) and its ratio to the cerebellum (SUVR), and intra-region coefficient of variation (CoV) between PoR and conventional registration. Significant differences in registration of as much as 2.74 mm and 3.02° were observed between the two methods (effect size <  − 0.8 or > 0.8), which resulted in considerable SUVR differences throughout the brain, reaching a maximal difference of 62.3% in the sensory motor cortex. Intra-region CoV was significantly reduced using the PoR throughout the brain. These results suggest that PoR reduces error as a result of imprecise registration in PVC and is a useful method for accurately quantifying the amyloid burden in PET.