bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential of zebrafish as a model to characterise MicroRNA profiles in mechanically mediated joint degeneration
Authors: Lawrence Elizabeth A. , Hammond Chrissy L. , Blain Emma J. 
Published: September 2020

AbstractMechanically mediated joint degeneration and cartilage dyshomeostasis is implicated in highly prevalent diseases such as osteoarthritis. Increasingly, MicroRNAs are being associated with maintaining the normal state of cartilage, making them an exciting and potentially key contributor to joint health and disease onset. Here, we present a summary of current in vitro and in vivo models which can be used to study the role of mechanical load and MicroRNAs in joint degeneration, including: non-invasive murine models of PTOA, surgical models which involve ligament transection, and unloading models based around immobilisation of joints or removal of load from the joint through suspension. We also discuss how zebrafish could be used to advance this field, namely through the availability of transgenic lines relevant to cartilage homeostasis and the ability to accurately map strain through the cartilage, enabling the response of downstream MicroRNA targets to be followed dynamically at a cellular level in areas of high and low strain.
Working conditions as risk factors for early exit from work—in a cohort of 2351 employees in Germany
Authors: d’Errico Angelo , Burr Hermann , Pattloch Dagmar , Kersten Norbert , Rose Uwe 
Published: September 2020

AbstractObjectivesWe would assess the possible impact of a range of physical and psychosocial working conditions on early exit from paid employment (i.e., before retirement age) in a representative employee population in Germany.MethodsWe analysed a cohort from the German Study on Mental Health at Work (S-MGA) with a baseline of 2351 employees in 2011/12, sampled randomly from the register of integrated employment biographies (IEB) at the Institute for Employment Research (IAB). Follow-up ended mid-2015. Early Exit comprised episodes of either pensioning, long-term sickness absence or unemployment ≥ 18 months. Total follow-up years were 8.422. Working conditions were partly assessed by the Copenhagen Psychosocial Questionnaire (COPSOQ). Through Cox regressions, associations of baseline working conditions with time to event of exit were estimated—adjusting for baseline age, gender, poverty, fixed-term contract and socioeconomic position.ResultsIn multiple regressions, awkward body postures (HR = 1.24; 95% CI = 1.07–1.44), heavy lifting (1.17; 1.00–1.37) and high work pace (1.41; 1.16–1.72) were associated with exit. The estimated attributable fraction of exit for being exposed to less than optimal work environment was 25%. Regarding specific exit routes, repetitive movements (1.25; 1.03–1.53) increased the risk for the long-term sickness absence; work pace (1.86; 1.22–2.86) and role clarity (0.55; 0.31–1.00) were associated to unemployment; and control over working time (0.72; 0.56–0.95) decreased the risk of the early retirement.ConclusionsWork environment seems to be important for subsequent early exit from work. Physical and psychosocial demands seem to be associated to exit to a stronger extent than resources at work.
Elastosis in ERα-positive male breast cancer
Authors: Vermeulen Marijn A. , van Deurzen Carolien H. M. , van Leeuwen-Stok A. Elise , van Diest Paul J. 
Published: September 2020

AbstractIn female breast cancer (BC), elastosis is strongly related to estrogen receptor alpha (ERα) expression. Male breast cancers almost invariably express ERα; so, the aim of this study was to investigate elastosis frequency in invasive male BC as well as clinicopathological correlations, in comparison with females. A total of 177 male BC cases and 135 female BC cases were included, all ERα-positive and invasive carcinoma of no special type. Elastosis on H&E-stained slides was scored in a four-tiered system as elastosis grade (EG) 0 (no elastosis) to EG3 (high amount of elastosis). EG scores in male BC were correlated to histopathological characteristics and overall surviva and compared with female BC EG scores. Male BC showed some degree of elastosis in 26/117 cases (22.2%) with none showing EG3, while female BC cases showed elastosis in 89/135 cases (65.9%) with 21.5% showing EG3 (p < 0.001). This difference retained its significance in multivariate logistic regression. In male BC cases, no significant correlations were found between the amount of elastosis and age, grade, mitotic activity index, and PgR. In addition, no significant prognostic value of elastosis was seen. In conclusion, despite high ERα expression, male BC showed significantly less elastosis than female BC. Elastosis did not show clinicopathological correlations or prognostic value. Therefore, elastosis seems to be a less useful ERα tissue biomarker with less clinical significance in male BC compared with females, pointing towards important BC sex differences.
Optimal reduction of public debt under partial observation of the economic growth
Authors: Callegaro Giorgia , Ceci Claudia , Ferrari Giorgio 
Published: September 2020

AbstractWe consider a government that aims at reducing the debt-to-(gross domestic product) (GDP) ratio of a country. The government observes the level of the debt-to-GDP ratio and an indicator of the state of the economy, but does not directly observe the development of the underlying macroeconomic conditions. The government’s criterion is to minimise the sum of the total expected costs of holding debt and of debt reduction policies. We model this problem as a singular stochastic control problem under partial observation. The contribution of the paper is twofold. Firstly, we provide a general formulation of the model in which the level of the debt-to-GDP ratio and the value of the macroeconomic indicator evolve as a diffusion and a jump-diffusion, respectively, with coefficients depending on the regimes of the economy. The latter are described through a finite-state continuous-time Markov chain. We reduce the original problem via filtering techniques to an equivalent one with full information (the so-called separated problem), and we provide a general verification result in terms of a related optimal stopping problem under full information. Secondly, we specialise to a case study in which the economy faces only two regimes and the macroeconomic indicator has a suitable diffusive dynamics. In this setting, we provide the optimal debt reduction policy. This is given in terms of the continuous free boundary arising in an auxiliary fully two-dimensional optimal stopping problem.
Outpatient, dental care of adult vulnerable patients under general anaesthesia—a retrospective evaluation of need for treatment and dental follow-up care
Authors: Jockusch Julia , Hopfenmüller Werner , Ettinger Ronald , Nitschke Ina 
Published: September 2020

Abstract
Objectives
To analyse the treatment needs of patients who had received dental treatment under GA and the effectiveness of the treatment provided.

Materials and methods
Retrospective chart analysis of adult at risk and vulnerable patients requiring dental treatment under GA (2007–2017). Outcome variables were indications for GA, DMF/T, and type of treatment, failure rates of treated teeth, emergencies and recall intervals after GA.

Results
Four hundred fourteen subjects (median age 42 years, range 18–93 years) were assigned to four groups (people with disabilities (pwdis), dementias (pwd), dental phobias (pwph), and addictions/psychosocial disorders (pwapd)) and attended the pre-GA assessment. Of these, 247 subjects (median 37 years, range 18–93 years) were treated under GA, mostly pwdis (n = 154, 69.7%). The main indication for treatment under GA was suspicion of pain (n = 178, 72.1%). Pwd had the highest degree of restoration (46.7%), DMF/T value (23.8), and most missing teeth (5.8). Pwapd had the most decayed teeth (12.9). There was a 12-month recall augmented by 2–4 oral hygiene sessions depending on compliance. The failure rate of all treated teeth was 4%. Two dental emergencies were reported for patients who received a GA.

Conclusions
Dental treatment need was high for adult vulnerable people. The diagnostic groups differed mainly in their subjective reason for need of a GA, their DMF/T, treatment needs and type of treatments performed. Failure and dental emergency rates after GA were low in spite of a recall interval of 12 months.

Clinical Relevance
Regular annual recalls could avoid dental emergencies in patients requiring treatment under GA.
Exact equivalence at cyclic steady state between isothermal diffusion and linear driving force models for linear adsorption systems
Authors: Brandani Stefano 
Published: September 2020

AbstractTo match the dynamics of a linear driving force model and the diffusion equation is of great practical importance in the design and optimization of adsorption separation processes. A frequency response analysis is applied to show that it is not possible to arrive at an equivalence based on a single parameter. Using this as the basis, a universal equivalence for the linear problem is constructed and closed form analytical expressions for the two parameters are derived for the sphere and slab geometries. The two parameters represent the increased effective mass transfer coefficient and a reduction in the active volume of the particle, both corresponding to the internal concentration profiles of the diffusion equation at cyclic steady state.
Improving the coordination in the humanitarian supply chain: exploring the role of options contract
Authors: John Lijo , Gurumurthy Anand , Mateen Arqum , Narayanamurthy Gopalakrishnan 
Published: September 2020

AbstractThe uncertainty associated with the location, severity and timing of disaster makes it difficult for the humanitarian organization (HO) to predict demand for the aid material and thereby making the relief material procurement even more challenging. This research explores whether options contract can be used as a mechanism to aid the HO in making procurement of relief material less challenging by addressing two main issues: inventory risk for buyers and over-production risk for suppliers. Furthermore, a contracting mechanism is designed to achieve coordination between the HO and aid material suppliers in the humanitarian supply chain through optimal pricing. The options contract is modelled as a stylized version of the newsvendor problem that allows the HO to adjust their order quantity after placing the initial order at the beginning of the planning horizon. This flexibility helps to mitigate the risk of both overstocking and understocking for the HO as well as the risk of overproduction for the supplier. Our results indicate that the optimal values for decision parameters are not “point estimates” but a range of prices, which can facilitate negotiation between the two parties for appropriate selection of contract parameters under an options contract. The results imply that options contract can aid in the decentralized approach of fixing the prices between the HO and the supplier, which in turn would help in achieving systemic coordination.
The effect of breast MRI on disease-free and overall survival in breast cancer patients: a retrospective population-based study
Authors: van Nijnatten T. J. A. , van Tiel L. P. T. , Voogd A. C. , Groothuis-Oudshoorn C. G. M. , Siesling S. , Lobbes M. B. I. 
Published: September 2020

Abstract
Purpose
To evaluate the effect of breast MRI on overall survival (OS) and disease-free survival (DFS) of patients with invasive breast cancer in the Netherlands.

Methods
We selected all women from the Netherlands Cancer Registry diagnosed with invasive breast cancer (a) between 2011 and 2013 for the OS-cohort and (b) in the first quarter of 2012 for the DFS-cohort. The study population was subdivided into an MRI and non-MRI group. In addition, subgroups were created according to breast cancer subtype: invasive carcinoma of no special type (NST) versus invasive lobular carcinoma (ILC). OS and DFS were compared between the MRI and non-MRI group using the Kaplan–Meier method and the log-rank test. Cox proportional hazard regression analysis was performed to estimate hazard ratios (HR) with a 95% confidence interval (CI). To account for missing data, multiple imputation was performed.

Results
Of the 31,756 patients included in the OS-cohort (70% non-MRI and 30% MRI), 27,752 (87%) were diagnosed with invasive carcinoma NST and 4004 (13%) with ILC. Of the 2464 patients included in the DFS-cohort (72% non-MRI and 28% MRI), 2161 (88%) were diagnosed with invasive carcinoma NST and 303 (12%) with ILC. The distribution of breast MRI use was significantly lower over different age categories, from 49.0% aged < 50 to 16.5% aged > 70. Multivariable Cox regression showed that breast MRI was not significantly associated with OS overall (HR 0.91, 95%-CI 0.74–1.11, p = 0.35), nor in the different histological subtypes. Multivariable Cox regression analysis showed that breast MRI was also not significantly associated with DFS (HR 1.16, 95%-CI 0.81–1.67), nor in the different histological subtypes.

Conclusion
Use of breast MRI was not significantly associated with an improved OS or DFS in patients treated with primary surgery.
Nanocellulose from fractionated sulfite wood pulp
Authors: Winter Armin , Arminger Benjamin , Veigel Stefan , Gusenbauer Claudia , Fischer Wolfgang , Mayr Melanie , Bauer Wolfgang , Gindl-Altmutter Wolfgang 
Published: September 2020

AbstractFine fibre fractions in wood pulp may contribute to advantageous paper properties, but in some instances their removal from pulp may be beneficial to the production process of certain paper grades. In order to study the suitability of fine fibre fractions for the production of nanocellulose as an alternative use option, sulfite pulp was fractionated and homogenised, and cellulose nanopapers were produced. Characterisation revealed that fine fibre fractions were more easily homogenised than long fibres. Aqueous suspensions of nanocellulose produced from fines showed remarkably reduced viscosity compared to nanocellulose derived from long fibres. Nanopapers produced from all nanocellulose variants showed roughly similar mechanical performance. Only nanopaper produced from primary fines-derived nanocellulose deviated in that it showed a comparably high modulus of elasticity at a low strain at failure. Overall, fine fibre fractions separated from wood pulp were found to be highly suitable for nanocellulose production.
Exacerbated Headache-Related Pain in the Single Prolonged Stress Preclinical Model of Post-traumatic Stress Disorder
Authors: Zhang Yong , Standifer Kelly M. 
Published: September 2020

AbstractChronic headache pain is one of the most commonly reported comorbid pain conditions with post-traumatic stress disorder (PTSD) patients and resistant to effective treatment, yet no combined preclinical model of the two disorders has been reported. Here, we used a modified chronic headache pain model to investigate the contribution of single prolonged stress (SPS) model of PTSD with sodium nitroprusside (SNP)-induced hyperalgesia. Injection of SNP (2 mg/kg, i.p.) occurred every other day from day 7 to day 15 after initiation of SPS in rats. Paw withdrawal threshold (PWT) to von Frey stimuli and tail flick latencies (TFL) dramatically decreased as early as 7 days after SPS and lasted until at least day 21. Basal PWT and TFL also significantly decreased during the SNP treatment period. The lower nociceptive thresholds recovered in 6 days following the final SNP injection in SNP group, but not in SPS + SNP group. Elevated nociceptin/OFQ (N/OFQ) levels observed in cerebrospinal fluid of SPS rats were even higher in SPS + SNP group. Glial fibrillary acidic protein (GFAP) and N/OFQ peptide (NOP) receptor mRNA expression increased in dorsal root ganglia (DRG) 21 days after SPS exposure; mRNA increases in the SPS/SNP group was more pronounced than SPS or SNP alone. GFAP protein expression was upregulated in trigeminal ganglia by SPS. Our results indicate that traumatic stress exaggerated chronic SNP-induced nociceptive hypersensitivity, and that N/OFQ and activated satellite glia cells may play an important role in the interaction between both conditions.
Climate change, crops and commodity traders: subnational trade analysis highlights differentiated risk exposure
Authors: Stokeld Emilie , Croft Simon A. , Green Jonathan M. H. , West Christopher D. 
Published: September 2020

AbstractThe global food system is increasingly interconnected and under pressure to support growing demand. At the same time, crop production is facing new and uncertain impacts from climate change. To date, understanding how downstream supply chain actors, such as commodity traders, are exposed to climate change risks has been difficult due to a lack of high-resolution climate and trade data. However, the recent availability of supply chain data linking subnational production to downstream actors, and gridded projections of crop yield under climate change, allows us to assess individual commodity trader exposure to long-term climate change risk. We apply such an analysis to soy production in Brazil, the world’s largest soy exporter. Whilst uncertainty across crop models’ yield projections means it remains difficult to accurately predict how production across the region will be affected by climate change, we demonstrate that the risk exposure of trading actors differs substantially due to the heterogeneity in their sourcing. Our study offers a first attempt to analyze subnational climate risk to individual trading actors operating across an entire production landscape, leading to more precise risk exposure analysis. With sufficient subnational data, this method can be applied to any crop and country combination, and in the context of wider food security issues, it will be pertinent to apply these methods across other production systems and downstream actors in the food system.
A polymatroid approach to generalized weights of rank metric codes
Authors: Ghorpade Sudhir R. , Johnsen Trygve 
Published: September 2020

AbstractWe consider the notion of a (q, m)-polymatroid, due to Shiromoto, and the more general notion of (q, m)-demi-polymatroid, and show how generalized weights can be defined for them. Further, we establish a duality for these weights analogous to Wei duality for generalized Hamming weights of linear codes. The corresponding results of Ravagnani for Delsarte rank metric codes, and Martínez-Peñas and Matsumoto for relative generalized rank weights are derived as a consequence.
Security analysis of permission re-delegation vulnerabilities in Android apps
Authors: Demissie Biniam Fisseha , Ceccato Mariano , Shar Lwin Khin 
Published: September 2020

AbstractThe Android platform facilitates reuse of app functionalities by allowing an app to request an action from another app through inter-process communication mechanism. This feature is one of the reasons for the popularity of Android, but it also poses security risks to the end users because malicious, unprivileged apps could exploit this feature to make privileged apps perform privileged actions on behalf of them. In this paper, we investigate the hybrid use of program analysis, genetic algorithm based test generation, natural language processing, machine learning techniques for precise detection of permission re-delegation vulnerabilities in Android apps. Our approach first groups a large set of benign and non-vulnerable apps into different clusters, based on their similarities in terms of functional descriptions. It then generates permission re-delegation model for each cluster, which characterizes common permission re-delegation behaviors of the apps in the cluster. Given an app under test, our approach checks whether it has permission re-delegation behaviors that deviate from the model of the cluster it belongs to. If that is the case, it generates test cases to detect the vulnerabilities. We evaluated the vulnerability detection capability of our approach based on 1,258 official apps and 20 mutated apps. Our approach achieved 81.8% recall and 100% precision. We also compared our approach with two static analysis-based approaches — Covert and IccTA — based on 595 open source apps. Our approach detected 30 vulnerable apps whereas Covert detected one of them and IccTA did not detect any. Executable proof-of-concept attacks generated by our approach were reported to the corresponding app developers.
Terahertz Conductivity Analysis for Highly Doped Thin-Film Semiconductors
Authors: Ulatowski Aleksander M. , Herz Laura M. , Johnston Michael B. 
Published: September 2020

AbstractThe analysis of terahertz transmission through semiconducting thin films has proven to be an excellent tool for investigating optoelectronic properties of novel materials. Terahertz time-domain spectroscopy (THz-TDS) can provide information about phonon modes of the crystal, as well as the electrical conductivity of the sample. When paired with photoexcitation, optical-pump-THz-probe (OPTP) technique can be used to gain an insight into the transient photoconductivity of the semiconductor, revealing the dynamics and the mobility of photoexcited charge carriers. As the relation between the conductivity of the material and the THz transmission function is generally complicated, simple analytical expressions have been developed to enable straightforward calculations of frequency-dependent conductivity from THz-TDS data in the regime of optically thin samples. Here, we assess the accuracy of these approximated analytical formulas in thin films of highly doped semiconductors, finding significant deviations of the calculated photoconductivity from its actual value in materials with background conductivity comparable to 102Ω− 1cm− 1. We propose an alternative analytical expression, which greatly improves the accuracy of the estimated value of the real photoconductivity, while remaining simple to implement experimentally. Our approximation remains valid in thin films with high dark conductivity of up to 104Ω− 1cm− 1 and provides a very high precision for calculating photoconductivity up to 104Ω− 1cm− 1, and therefore is highly relevant for studies of photoexcited charge-carrier dynamics in electrically doped semiconductors. Using the example of heavily doped thin films of tin-iodide perovskites, we show a simple experimental method of implementing our correction and find that the commonly used expression for photoconductivity could result in an underestimate of charge-carrier mobility by over 50%.
Does capacity increase compliance? Examining evidence from European cooperation against air pollution
Authors: Tveit Andreas Kokkvoll 
Published: September 2020

AbstractScholars commonly hypothesize that enhanced capacity—improved ability to do as agreed—increases states’ compliance with international agreements. In contrast, using a novel dataset that covers 31 states and three decades of cooperation, I find a negative effect of capacity on compliance. To help explain this seemingly counterintuitive finding, I offer a novel conjecture of the capacity–compliance relationship. In particular, I argue that the effect of capacity may vary substantially across states, because states’ intention to comply constitutes a crucial intervening variable. Among reluctant states pursuing policy goals that affect compliance negatively, high capacity may in fact cause noncompliance. I exemplify the conjecture through evidence from a high-capacity noncompliant state (Norway).