bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects and safety of platelet-rich plasma (PRP) and hyaluronic acid (HA), alone and in combination, in the treatment of knee osteoarthritis: A systematic review and meta-analysis.
Authors: Zhao Jinlong , Huang Hetao , Liang Guihong , Zeng Ling-feng , Yang Weiyi , Liu Jun 
Published: February 2020

Abstract
Background Studies have shown that the combined application of hyaluronic acid (HA) and platelet-rich plasma (PRP) can repair degenerated cartilage and delay the progression of knee osteoarthritis (KOA). The purpose of this study was to explore the efficacy and safety of PRP combined with HA in the treatment of KOA compared with intra-articular injection of PRP or HA alone. Methods The PubMed, Cochrane Library, EMBASE and China National Knowledge Infrastructure (CNKI) databases were searched from inception to December 2019. Two orthopaedic surgeons conducted the literature retrieval and extracted the data. Outcome indicators include the Western Ontario and McMaster Universities Arthritis Index (WOMAC), the Lequesne Index, the visual analogue scale (VAS) for pain, and adverse events (AEs). Results Seven studies (5 randomized controlled trials, 2 cohort studies) with a total of 941 patients were included. In the VAS comparison after 6 months of follow-up, PRP combined with HA was more likely to reduce knee pain than PRP alone (standardized mean difference (SMD): -0.31; 95% confidence interval (CI): -0.55 to -0.06; P=0.01 <0.05). PRP combined with HA for KOA achieved better improvement in WOMAC Function Score (SMD: -0.32; 95% CI: -0.54 to -0.10) and WOMAC Total Score (SMD: -0.42; 95% CI: -0.67 to -0.17) at the 12-month follow-up than the application of PRP alone. In a comparison of Lequesne Index scores at a 6-month follow-up, PRP combined with HA improved knee pain scores more than PRP alone (SMD: -0.42; 95% CI: -0.67 to -0.17). In terms of AEs, PRP combined with HA was not significantly different from PRP or HA alone (P>0.05). Conclusions Compared with intra-articular injection of PRP alone, PRP combined with HA can improve WOMAC Function Scores, WOMAC Total Score, 6-month follow-up VAS ratings, and Lequesne Index scores. However, in terms of the incidence of AEs, PRP combined with HA was not significantly different from PRP or HA alone.
Validation and reliability of a simplified food frequency questionnaire: A cross sectional study among physical health examination adults in southwest region of China
Authors: Cheng Zhengyan , Shuai Ping , Qiao Qichuan , Li Tingxin 
Published: February 2020

Abstract
Background In China, many people are apt to participate in regular physical examination as a precaution. Some simplified food frequency questionnaire have been designed and used. However, the effectiveness of questionnaire is absent. This study was conducted to examine the reliability and validity of simplified food frequency questionnaire (SFFQ) used among physical examination adults in southwest region of China. Methods This study was a cross sectional study among physical health examination adults in Southwest region of China. A total of 239 participants aged 20-65 were conducted during February to June in 2019. The performance of the SFFQ was evaluated by the mean of three-day 24-hour dietary recalls (3R24). The relative validity and agreement was assessed by the Pearson`s correlation and intra-class correlation coefficients(ICC) respectively. Results The median energy-adjusted ICC of food groups between SFFQ2 and SFFQ1 was 0.59 (range: 0.49-0.73) and the ICC of nutrients was 0.47(range: 0.39-0.76). The Pearson correlation showed the validity between the SFFQ1 and 3R24, which ranged from -0.086 to 0.93 for food and and 0.21 to 0.71 for nutritions, respectively. Energy-adjustment slightly increased the correlation coefficients. Conclusions The reliability and validity of the SFFQ was acceptable. It could be an appropriate dietary assessment tool for future epidemiological studies in physical health examination adults among Chinese in southwest China.
GENOGRAMA MANUAL VERSUS VIRTUAL: COMPARABILIDADE DA APLICABILIDADE DOS MÉTODOS
Authors: Ivastcheschen Taís , Santos Rulliane Aparecida dos , Sicorra Thayne Da Rosa , Silva Junior Manoelito Ferreira 
Published: February 2020

Objetivo: descrever a aplicabilidade do genograma como ferramenta para gestão da clínica e comparar a aplicação em modo manual e virtual. Método: estudo qualitativo, descritivo, do tipo relato de experiência, realizado por acadêmicas de enfermagem, no período de maio a junho de 2019. Dados coletados por meio de entrevista semi-estruturada com a paciente em visita domiciliar e após elaboração do genograma de maneira manual e na versão virtual. Resultados: observou-se na construção teórica do trabalho que poucos profissionais da saúde sabem como usar esta ferramenta e como ela pode agregar a prática diária. Verificou-se a importância do genograma na aproximação do profissional com o paciente, organização do processo de trabalho e leitura rápida e abrangente da organização familiar. Com o genograma manual foi necessário consulta dos símbolos e seus significados em materiais de apoio, para a versão virtual foi necessário um cadastro, leitura breve do manual de instruções e então preenchimento dos campos de informação no site. No geral o genograma permite combinar informações de determinada família, compreender o individuo no seu contexto, localizar o problema de saúde, explorar e aconselhar situações problema, possui não só valor diagnóstico, mas também terapêutico. Conclusão: a aplicação do genograma foi uma experiência enriquecedora na prática acadêmica, demonstrou que esta ferramenta acrescentada à gestão da clinica, enriquece o processo de trabalho de profissionais da saúde, proporciona melhorias no atendimento aos usuários e facilita a organização de ações, entre o genograma manual e o virtual, observou-se a melhor desenvoltura da versão online por ser mais rápida e padronizada, no entanto, depende de computador e internet.
Removal of Targeted Pharmaceuticals and Personal Care Products from Wastewater Treatment Plants using QSAR Model
Authors: Madhura Lavanya , Singh Shalini , Kanchi Suvardhan , Sabela Myalowenkosi I. , Bisetty Krishna , Inamuddin  
Published: February 2020

Background:
Because of their intrinsic ability to induce physiological effects in humans
at low doses, pharmaceuticals and personal care products (PPCPs) are a unique group of emerging
environmental pollutants. A number of studies have confirmed the occurrence of different PPCPs in
the environment, which raises concerns about possible adverse effects on humans and wildlife. The
removal of PPCPs from wastewaters has become a major activity to reduce pollution due to their adverse
effects on humans and aquatic ecosystems.

Methods:
This study aimed to design a Quantitative Structure Activity Relationship (QSAR) model
for the removal of 57 PPCPs from wastewater treatment plants (WWTPs) of historical data obtained
from plants located in South Korea. The target compounds of PPCPs were optimised geometrically
using a Forcite-Geometry code, assembled in Material Studio 2016.

Results:
The removal efficiency of PPCPs is dependent on several preliminary molecular descriptors
including rotatable bonds (RBs), hydrogen bond donor (HBD), total molecular mass (TMM), binding
energy (BE), atom count (AC), element count (EC), total energy (TE), total dipole (TD), highest occupied
molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO). A Genetic
Function Approximation (GFA) method was adopted to perform regression analysis and create correlation
between experimental data (literature) and measured data (QSAR model).

Conclusion:
A QSAR model equation was established and used to predict removal efficiency of 57
PPCPs; the results obtained showed goodness of fit, R2 greater than 0.90 indicating that the internal
and external validations were also performed on the model.
Moralitas politik dalam pemilu 2004 dan implikasinya bagi Pendidikan Kewarganegaraan
Authors: Cholisin Cholisin 
Published: February 2020

Morality in general election 2004, a long way off from expected. Various actions which dissolute political indication see clearly in course of and result of general election. Money politics, administrative collusion and crime by some of all legislative candidates, bureaucracy which not yet neutral politically, manipulation of voice enumeration, showing process of general election still not yet full respect the moral. General election also did not yet shown to yield all politician owning high binding (commitment) to respect the political morality. Its indication, general election not yet earned to yield the leader owning inner calm and trusted by people, general election tends to yield the politician principled weak politics party at ideology so that progressively strengthen to expand "political of corruption. " Not yet strength of political morality in general election 2004 represented factor which did not conducive for civic education, because real reference of citizen about how politicians have moral. This circumstance if let it can conducive to the belief crisis to existing political system. Therefore, study of civic education agreed with general election which require to be developed critically to form the rational and proportional attitude in general election. If this matter is done will be able to assist to overcome to expand belief crisis to general election and national of political system.
Telaah kritis terhadap Undang-Undang No. 32 Tahun 2004 tentang Pemerintahan Daerah
Authors: Suharno Suharno 
Published: February 2020

The Constitution (UUD 1945) actually gave an opportunity for implementation of decentralist governmental system. But the New Order's Regime was not given enough manual for institutionalized decentralist government system. The idea to implement decentralist government system keep roll on until the issue of the Bill on Local Government No.32 Tabun 2004 as a completion of its previous. The wide authority to implement local governmental autonomy given by that bill implied politically as the discretion, scope and volume of local politic being wider and by managerial also make the tasks and responsibility of local government being wider and heavier.
Effect of a WeChat-Based Intervention (Run4Love) on Depressive Symptoms Among People Living With HIV in China: A Randomized Controlled Trial
Authors: Guo Yan , Hong Y Alicia , Cai Weiping , Li Linghua , Hao Yuantao , Qiao Jiaying , Xu Zhimeng , Zhang Hanxi , Zeng Chengbo , Liu Cong , Li Yiran , Zhu Mengting , Zeng Yu , Penedo Frank J 
Published: February 2020

Background
People living with HIV (PLWH) have high rates of depressive symptoms. However, only a few effective mental health interventions exist for this vulnerable population.

Objective
The aim of this study was to assess the efficacy of a WeChat-based intervention, Run4Love, with a randomized controlled trial among 300 people living with HIV and depression (PLWHD) in China.

Methods
We recruited PLWH from the HIV outpatient clinic in South China. Participants were screened based on the Center for Epidemiologic Studies-Depression (CES-D) scale. Those who scored 16 or higher were eligible to participate. A total of 300 eligible patients were enrolled. After obtaining informed consent from the participants, completion of a baseline survey, and collection of participants’ hair samples for measuring cortisol, the participants were randomly assigned to an intervention or a control group in a 1:1 ratio. The intervention group received the Run4Love program, delivered via the popular social media app WeChat. Cognitive behavioral stress management courses and weekly reminders of exercise were delivered in a multimedia format. Participants’ progress was monitored with timely and tailored feedback. The control group received usual care and a brochure on nutrition for PLWH. Data were collected at 3, 6, and 9 months. The primary outcome was depression, which was measured by a validated instrument.

Results
Participants in the intervention and control groups were comparable at baseline; about 91.3% (139/150), 88.3% (132/150), and 86.7% (130/150) participants completed the 3-, 6-, and 9-month follow-ups, respectively. At the 3-month follow-up, a significant reduction in CES-D score was observed in the intervention group (from 23.9 to 17.7 vs from 24.3 to 23.8; mean difference=−5.77, 95% CI −7.82 to −3.71; P<.001; standard effect size d=0.66). The mean changes in CES-D score from baseline to the 6- and 9-month follow-ups between the two groups remained statistically significant. No adverse events were reported.

Conclusions
The WeChat-based mobile health (mHealth) intervention Run4Love significantly reduced depressive symptoms among PLWHD, and the effect was sustained. An app-based mHealth intervention could provide a feasible therapeutic option for many PLWHD in resource-limited settings. Further research is needed to assess generalizability and cost-effectiveness of this intervention.

Trial Registration
Chinese Clinical Trial Registry ChiCTR-IPR-17012606; http://www.chictr.org.cn/showproj.aspx?proj=21019 (Archived by WebCite at https://www.webcitation.org/78Bw2vouF)
HoloLens-Based Vascular Localization System: Precision Evaluation Study With a Three-Dimensional Printed Model
Authors: Jiang Taoran , Yu Dewang , Wang Yuqi , Zan Tao , Wang Shuyi , Li Qingfeng 
Published: February 2020

Background
Vascular localization is crucial for perforator flap transfer. Augmented reality offers a novel method to seamlessly combine real information with virtual objects created by computed tomographic angiography to help the surgeon “see through” the skin and precisely localize the perforator. The head-mounted display augmented reality system HoloLens (Microsoft) could facilitate augmented reality–based perforator localization for a more convenient and safe procedure.

Objective
The aim of this study was to evaluate the precision of the HoloLens-based vascular localization system, as the most important performance indicator of a new localization system.

Methods
The precision of the HoloLens-based vascular localization system was tested in a simulated operating room under different conditions with a three-dimensional (3D) printed model. The coordinates of five pairs of points on the vascular map that could be easily identified on the 3D printed model and virtual model were detected by a probe, and the distance between the corresponding points was calculated as the navigation error.

Results
The mean errors were determined under different conditions, with a minimum error of 1.35 mm (SD 0.43) and maximum error of 3.18 mm (SD 1.32), which were within the clinically acceptable range. There were no significant differences in the errors obtained under different visual angles, different light intensities, or different states (static or motion). However, the error was larger when tested with light compared with that tested without light.

Conclusions
This precision evaluation demonstrated that the HoloLens system can precisely localize the perforator and potentially help the surgeon accomplish the operation. The authors recommend using HoloLens-based surgical navigation without light.
Актуальні питання медичного захисту військовослужбовців Збройних сил України від бойових отруйних речовин
Authors: Ustinova L.A. , Saglo V.I. , Barkevich V.A. , Kurdil N.V. , Yevtodiev A.A. , Kaplyuk O.B. 
Published: February 2020

Актуальність. Накопичення величезних обсягів хімічної зброї у світі, продовження наукових робіт щодо її вдосконалення і випадки застосування в терористичній діяльності роблять питання захисту військовослужбовців Збройних сил України від бойових отруйних речовин вкрай актуальними. Мета дослідження: оцінити сучасний стан медичного захисту та забезпечення антидотами військовослужбовців Збройних сил України від бойових отруйних речовин нервово-паралітичної дії. Матеріали та методи. Проведено аналіз забезпечення антидотами військовослужбовців у Збройних силах України за останні 20 років. Розглянуто накази Міністерства оборони і Міністерства охорони здоров’я України, що стосуються комплектно-табельного оснащення медичної служби Збройних сил України. Застосовані методи дослідження: історичний, бібліосемантичний і системного підходу. Результати. Установлено, що в кінці 90-х — на початку 2000-х років у переліку і змісті сумок і комплектів медичної служби Збройних сил України перебували в достатній кількості всі необхідні медикаменти військового призначення. На жаль, сьогодні серед індивідуальних комплектів медичного захисту профілактичні антидоти до речовин нервово-паралітичної дії відсутні. Також відсутні необхідні антидоти і засоби фармакологічної корекції при впливі отруйних речовин в інших сумках і комплектах, що застосовуються в підрозділах і частинах. Слід враховувати, що сьогодні на сході України під контроль терористів потрапило багато промислових підприємств, терористичні диверсії на яких можуть спричинити надзвичайні ситуації техногенного та військового характеру, які за масштабами і наслідками близькі до застосування хімічної зброї. Висновки. Виявлена повна відсутність оснащення медичної служби Збройних сил України медичними засобами профілактики, надання допомоги і лікування уражених отруйними речовинами. Сьогодні в умовах сучасного збройного конфлікту, де ймовірність застосування зброї масового ураження, в тому числі отруйних речовин нервово-паралітичної дії, вкрай висока, наявність антидотів до бойових отруйних речовин є критично важливою умовою для збереження життя і боєздатності особового складу.
Вплив гемофільтрації на загальний стан онкохворих після мультиорганних операцій
Authors: Krasnoselskiy M.V. , Krutko Ye.M. , Khramtsov R.E. 
Published: February 2020

Мета роботи: дослідити вплив гемофільтрації у хворих після мультиорганних оперативних втручань. Матеріали та методи. Вивчались післяопераційні ускладнення у хворих з мультиорганними оперативними втручаннями. Проводились клініко-інструментальні, біохімічні, клінічні, статистичні дослідження; використовувались кардіомонітор Heaco, апарати ультразвукової діагностики й електрокардіографії. Результати. При проведенні в комплексі інтенсивної терапії гемофільтрації та аналізу її впливу на тяжкість стану за шкалами Sequential Organ Failure Assessment і коми Глазго унаслідок гемофільтрації показники тяжкості стану знизились в 1,2 раза. Висновки. Запропонована методика гемофільтрації дозволила знизити число післяопераційних гнійно-септичних ускладнень в основній групі в 1,4 раза і сприяла зменшенню ризику розвитку синдрому поліорганної дисфункції на 33,8 % в основній групі проти групи порівняння.
Епідуральна аналгезія як метод вибору анестезіологічного забезпечення розродження у вагітних із прееклампсією середнього ступеня тяжкості
Authors: Mrochko Yu.V. , Pidhirnyy Ya.M. 
Published: February 2020

У статті висвітлено проблему анестезіологічного забезпечення фізіологічного розродження у вагітних із прееклампсією. Прееклампсія є специфічним мультиорганним розладом, що виникає з другого/третього триместру вагітності та супроводжується такими критичними станами, як еклампсія, HELLP-синдром, гостре ураження нирок, набряк мозку. Основними ускладненнями для плода є обмеження росту, недоношеність та мертвонароджуваність. У післяпологовому періоді у таких жінок підвищується ризик виникнення артеріальної гіпертензії, цукрового діабету та інвалідизації. До цього часу залишається актуальною проблемою анестезіологічне забезпечення процесу розродження пацієнток із прееклампсією. Нами висвітлено досвід проведення анестезіологічного забезпечення пологів у вагітної з прееклампсією середнього ступеня тяжкості за допомогою епідуральної аналгезії низькоконцентрованими місцевими анестетиками (10,0 мл 0,125% розчину ропівакаїну). Під час проведення анестезіологічного забезпечення пологів у вагітної з прееклампсією контролювалися показники гемодинаміки та рівня болю до пологів, через 24 години та на третю добу після розродження. За результатами досліджень можна стверджувати, що епідуральна аналгезія допустимо знижує гемодинамічні показники, водночас негативно не впливає на процес фізіологічних пологів та може бути методом вибору анестезіологічного забезпечення розродження у цієї категорії вагітних.
COGNITIVE INHIBITION TESTED BY STROOP COLOUR WORD TASK IN EFL TEACHERS AS SUCCESSIVE BILINGUALS
Authors: Šorgić Ivana , Nešić Marija 
Published: February 2020

This paper is a partial replication study of the one done by Heidlmayr et al. (2014), and concerns the effect of second language use on inhibitory control/cognitive inhibition analysed by means of a Stroop Colour Word task in both L1 and L2, i.e. Serbian and English. Our aim was to test the starting hypothesis of the original research which states that the frequency of L2 use in successive bilinguals has an impact on their inhibitory control mechanism. The bilingual subjects asked to take part in the study by doing the bilingual version of the test are all EFL teachers at the Faculty of Philosophy in Nis. Their use of L2 is akin to that of bilinguals living in an L2 environment (such as those from the original research), in the sense that they communicate daily using L2 and cover a wide variety of topics with their students. Our monolingual subjects, who served as control group, were randomly chosen from the same age group as bilinguals (older adults). They were asked to do only the L1 version of the test. The purpose of this small-scale research was to give a contribution to the ever-growing debate concerning the cognitive advantages of bilingualism.
A HUMAN CROWD EFFECT MODELLED BY THE DISCRETE-TIME FOURIER SERIES
Authors: Jovanović Miomir , Radoičić Goran 
Published: February 2020

Accidental actions caused by vibrations of supporting structures in mechanical systems represent the dynamic tasks of specific scientific and professional research in the field of human and equipment safety. This paper determines the mathematical model of physical excitation force created by human power, based on the discrete-time Fourier transformation. For experimental verification of the model, we made a special platform for measuring bouncing force of people who create natural impulse oscillation. The paper shows the results of individual and group experimental testing of living force as the cause of accidents and dangerous effects on the structure. In the end, the excitation of the human operation of a malicious nature (heavy transport machine – crane) has been used to show the application of Fourier model to simulate one incident. For this purpose, the transient FEM analysis and the eigenvalues predetermined modal analysis are used. The paper is illustrated with photographs of experimental tests of dangerous human impulse in several working machines (objects).