bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing Two Treatment Approaches for Patients with Type 1 Diabetes During Aerobic Exercise: A Randomised, Crossover Study
Authors: Vartak Varun , Chepulis Lynne , Driller Matthew , Paul Ryan G. 
Published: June 2020

Abstract
In a randomised, counterbalanced, crossover design, eight men with type 1 diabetes (T1D; mean ± SD age: 27.6 ± 11.4 years) reduced insulin (INS) or consumed carbohydrates without the usual insulin bolus (CARBS) over two sessions, held a week apart. Each session included standardised meals, a 45-minute treadmill-walk at 7.24 km.h-1 and a six-minute walk test (6MWT). Rate of perceived exertion (RPE), blood glucose, blood ketone and blood lactate measures were taken before, during and immediately after the aerobic exercise. The distance covered and the predicted VO2 max were also calculated for the 6MWT. Participants completing the INS intervention spent more time in normoglycaemia (P < 0.01) and less time in hyperglycaemia (P = 0.01) as compared to the CARBS intervention. Mild hypoglycaemia occurred in two participants during INS and no participants during CARBS. Furthermore, there was no significant difference for blood lactate, ketone, RPE, distance covered and predicted VO2 max between interventions. Six of the eight participants felt that their performance was better during INS, with all six (including the two participants that experienced mild hypoglycaemia) indicating that they would prefer to use this strategy for management of glycaemic during exercise in the future. Based on this pilot study, INS intervention appears to be the best approach for maintaining blood glucose levels in those with T1D during aerobic exercise, though this does need evaluating in other groups, including women, children and those with sub-optimal glycaemic control.Trial registration: ACTRN12619001397101p. Registered 09 September 2019, http://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=378264
Anaemia and Associated Factors Among Pregnant Women Attending Antenatal Care Follow-Up at Yabello General Hospital Living in Pastoralist Borena Zone, Oromia, Ethiopia From From July to August, 2019
Authors: Arero Godana , Asssefa Kinde 
Published: June 2020

Abstract
Objective: The purpose of the study is to assess magnitude of anemia and associated factors among pregnant women attending antennal care follow-up at Yabello General Hospital in Pastoralist Borena Zone from July-August, 2019.Method: A hospital based cross-sectional study design was employed among 265 pregnant women attending antenatal care at Yabello General Hospital from June 17-August 16 2019. A systematic random sampling technique was used to select two hundreds sixty five study subjects. The first study subject was chosen randomly by simple random sampling method blindly picking one of two using pieces of papers named for the first two visitors. The sampling interval (K) calculated to be 2, and then, every second pregnant woman who attending antenatal care was recruited.Socio-demographic, maternal nutrition, information and obstetric and medical characteristics were assessed. Hemoglobin value, stool examination, HIV and syphilis test results were collected from their regular laboratory tests. Blood film was conducted for pregnant women who had signs and symptoms and whose hemoglobin value less than the established cut of values and data were analyzed using SPSS version 20.0 softwareResults: Magnitude of anemia with median hemoglobin value were (11.10g/dl ± 1.66); majority 46(63.9%) had mildly anemia, 24(33.3%) moderate and 2(2.8%) were severe anemia. Urban dwellers women (AOR, 95% CI: .18(.05-.64)), for those who had abortion before current pregnancy (AOR, 95% CI: 3.08(1.17-8.13)); coffee/tea drinking immediately after meal (AOR, 95% CI: 4.39(1.82-10.59), & who had excessive menstrual bleeding before current pregnancy were (AOR, 95% CI: 3.39(1.47-7.84)) & mid-upper arm circumference less than 23cm (AOR, 95% CI: 6.27(1.15-14.30)) were found to be independent predictors of anemia among pregnant women.Conclusion: Anemia in study area among pregnant women in Ethiopia was higher as compare with similar study elsewhere. Malnutrition, abortion, excessive bleeding & nutrition interaction with other inhibitors like coca cola, tea and coffee immediately after meals were independent predictors for anemia.
Risk Factors for Technical Difficulty of Endoscopic Submucosal Dissection in Colorectal Tumors: A Case Series and Meta-Analysis
Authors: Gao Yan , Jiang Wei , Zhai Hui-Hong , Xu Jianing , Wu Shanshan , Zhang Shutian 
Published: June 2020

Abstract
Background and Aims: Endoscopic submucosal dissection has become widely accepted as an efficient and well-established option for colorectal neoplastic lesions (CRNs). However, there are still some barriers for endoscopists that hinder the successful ESD. The current study was to evaluate risk factors for the failure of en-bloc resection in the colorectal endoscopic submucosal dissection (ESD).Methods: A retrospective chart review was performed from patients who underwent ESD for colorectal neoplasms (CRNs) between January 2015 and April 2017. The demographics and colonoscopic reports were analyzed. A meta-analysis was conducted for the risk factors for the failure of en-bloc or R0 resection. Results: 253 ESD cases were completed in en-bloc resection. Ulcerative colitis, previous abdominal surgeries, lesions on the Bauhin’s valve/ dentate line, non-lifting sign and submucosal fibrosis were associated with the failure of en-bloc resection (P<0.05). Meta-analysis showed that laterally spreading tumors, tumor larger than 40mm, Bauhin’s valve/dentate line, flexure, non-lifting sign, and submucosal fibrosis were the factors for the failure of en bloc or R0 resection. The rates of perforation were obviously higher in N-EBR groups compared to EBR groups. No significant results can be observed on the local recurrence based on these studies. Conclusions: Preoperative factors such as laterally spreading tumors, tumor larger than 40mm, Bauhin’s valve/dentate line, flexure and intraoperative factors such as non-lifting sign, submucosal fibrosis should be put more focus to reach better outcomes in CRNs patients.
Computer-aided three-dimensional assessment of periodontal healing distal to the mandibular second molar after coronectomy of the mandibular third molar: a prospective study
Authors: Yan Ziyu , Tan Yao , Xie Xiaoyan , He Wei , Guo Chuanbin , Cui Nianhui 
Published: June 2020

Abstract
Background
The periodontal healing distal to the mandibular second molar (M2M) after coronectomy of the M3M was controversary. This study aimed to combine a digital method with cone-beam computed tomography (CBCT) and estimate periodontal healing of M2M after M3M coronectomy. An accurate and stable indicator in three dimensions was also tentatively explored.
Methods
Patients with a M3M in contact with the inferior alveolar canal were included. CBCT was applied immediately after coronectomy (baseline) and 6-months later. Data were investigated with digital software for registration. Previously reported and coronectomy-related factors were included for univariate and multivariate analyses.
Results
A total of 181 patients (213 M3Ms) completed 6-month follow-up. Significant reduction in the distal intra-bony defect (DBD) depth of the M2M was shown (1.28 ± 1.24 mm, P < 0.001). DBD depth of the M2M at baseline was the most influential factor (r = 0.59), followed by preoperative M3M condition, age, rotation and eruption of the root complex. Remaining enamel (OR = 6.93) and small retromolar space (0.67) contributed to re-contact of the root complex and M2M. Bone volume regenerated in the distal 2 mm was associated significantly with DBD-depth reduction (r = 0.74, P < 0.001).
Conclusions
Bone volume regenerated in the distal 2 mm of the M2M denoted stability of distal periodontal healing of the M2M. DBD depth at baseline was the most influential factor for healing of a DBD of the M2M after M3M coronectomy. The remaining enamel and a small retromolar space could contribute to re-contact of the root complex and the M2M.
Trial registration:
China Clinical Trial Center, ChiCTR1800014862. Registered 10 February 2018, http://www.chictr.org.cn/showproj.aspx?proj=24216
Knowledge Among the Rural Parents About the Vaccinations and Vaccination Coverage of Children in the First Year of Life in Papua New Guinea – Analysis of Data Provided by Christian Health Services
Authors: Gowin Ewelina , Kuzma Jerzy , Januszkiewicz-Lewandowska Danuta 
Published: June 2020

Abstract
Knowledge among the rural parents about the vaccinations and vaccination coverage of children in the first year of life in Papua New Guinea – analysis of data provided by Christian Health Services.BackgroundThe aim of this analysis was to establish knowledge among the rural parents about the vaccinationsvaccination coverage of children in the first year of life in Papua New Guinea (PNG).Methods56 parents including 52 mothers and 4 fathers from 2 areas Simbu Province (Kervagi district) and Morobe Province (Finschhafen district). We analysed knowledge among the rural parents about the diseases prevented by vaccinations. data on vaccination coverage from 2016 to 2018 from all Catholic health facilities. Analysed vaccinations were the pentavalent vaccine (DTaP-HiB-HepB) and measles vaccine given in the first year of life.ResultsDuring the analysed period a total of 25,502 doses of measles vaccine was given, 31,428 children were vaccinated with the pentavalent vaccine. In 2016, the coverage rate for the measles vaccine was 26.6% and 33.4% for the pentavalent vaccine. In 2017, the coverage rate for measles and pentavalent vaccines was 12.5% and 16.6%, respectively. There were big differences in immunization coverage between provinces. In 2016, greater than 80% coverage was noted in one province for measles vaccine and in four provinces for pentavalent vaccine. In 2017, in none of the provinces, the coverage rate, neither for pentavalent nor for measles vaccine, was higher than 80%. A decreasing trend in the number of administered vaccinations was observed.ConclusionThe results of this analysis demonstrate that in PNG, the majority of children are not fully immunised. There are big differences in the vaccination coverage between provinces. As protection from diseases is low, there is a very high risk of an outbreak of the vaccine-preventable disease in the community.Delivery of vaccinations in PNG encounters many barriers from access to healthcare services to natural disasters and inter-tribial conflicts.Trial registration NA
The Effects of Management of Infection Source of Echinococcosis in Linzhi, Tibet Autonomous Region of China
Authors: Wang Ying , Ma Bing-Cheng , Wang Li-Ying , Quzhen Gongsang , Pang Hua-Sheng 
Published: June 2020

Abstract
BackgroundEchinococcosis is highly endemic in western and northern China，Tibet Autonomous Region （TAR）is one of the most serious prevalent area with the prevalence of echinococcosis in humans was 1.66% and in dog was 7.30% in 2016. Linzhi is located in southeastern part of TAR with the prevalence of echinococcosis in humans was 1.55% and in dog was 7.28% in 2016.，Dogs are the main infection source for the transmission of echinococcosis to humans. A control and prevention campaignbased on dog management has been undertaken in the past three years. This study is toevaluate the effects of dog management on prevalence of echinococcosis in dogs.MethodsData of dog population, registration and de-worming of 7 counties/district in Linzhi from 2017 to 2019 were collected. Domestic dog fecal samples were collected from each endemic town of7 counties/district in Linzhi in 2019 to determine infection of dog using coproantigen ELISA. Data analysis was processed using SPSS statistics to compare dog infection rate between 2016 and 2019 by chi-square test, and maps were mapped using ArcGIS.ResultsIn Linzhi, domestic dog population with 17407, 16512, 12663 decreased and the registration rate with 5.92%, 95.48%, 98.64% increased each year from 2017 to 2019. Similarly, stray dog population with 14336, 13067, 11837 decreased while sheltered rate with 84.63%, 92.32% 96.63% increased year by year. Dog de-worming frequency increased from 4 times per annum in 2017 to 12 times in 2019, almost every dog was dewormed monthly. A total of 2715 dog fecal samples were collected for coproantigen ELISA assay. The dog infection rate was 2.84% (77/2715) in 2019, which significantly lower than 2016 with 7.28% (45/618) (P＜0.05).ConclusionIncreased dog registration, decreased dog population and increased dog de-worming frequency contributed to significantly decreased dog infection rate in Linzhi, TAR. Control and prevention campaign based on dog management can significantly decrease dog infection with Echinococcus spp in echinococcosis endemic areas but needs strictly implementation.
High immune efficacy against different avian influenza H5N1 viruses by oral administration of a Saccharomyces cerevisiae-based vaccine in chickens
Authors: Lei Han , Cen Qianhong , Gao Tong , Ren Yi , Lu Xin 
Published: June 2020

Abstract
BackgroundA safe and effective vaccine is the best way to control large-scale highly pathogenic avian influenza virus (HPAI) A (H5N1) outbreaks. Saccharomyces cerevisiae (S. cerevisiae) is an ideal mucosal delivery vector for vaccine development, and we have previously shown that conventional injection administration with a S. cerevisiae-based vaccine (EBY100/pYD1-HA) was protective against homologous H5N1 virus in a mouse model. Due to the diameter of S. cerevisiae is around 10 μm which results in a severe inflammation by injection route, therefore, oral administration is a more suitable approach for EBY100/pYD1-HA conferring cross-protection in poultry. ResultsWe extended our work by evaluating the immunogenicity and cross-protective efficacy of oral vaccination with EBY100/pYD1-HA in the chicken model. Oral immunization with EBY100/pYD1-HA could induce robust serum IgG, mucosal IgA and cellular immune responses. Importantly, EBY100/pYD1-HA provided complete cross-protection against different H5N1 viruses challenge. ConclusionsThese findings suggest EBY100/pYD1-HA, a promising H5N1 oral vaccine candidate, can avoid potential reassortment of other avian influenza viruses in oral administration of live virus vaccines and overcome the drawbacks of conventional injection route. Importantly, this platform will be able to provide opportunities for broader applications in poultry during HPAI A (H5N1) outbreaks.
Quality Evaluation in Delivering Care of Acute Myocardial Infarction in Sancti-spirítus, Cuba
Authors: Rodriguez-Ramos Miguel Alejandro , Cairo-Saez Gilberto , Prohias-Martinez Juan Antonio 
Published: June 2020

Abstract
Background: Prevalence of cardiac conditions is increasing worldwide. Low and middle-income scenario (LMISs), especially in Latin America, don’t scape from this phenomenon. To give a high-quality cardiovascular disease care may be economic challenging for these countries, in every level of attention.Methods: Observational and retrospective study of quality of care evaluation using the European Society of Cardiology (ESC 2017) Quality of Care Working Group’s consensus on quality document, of admitted Acute Myocardial Infarction in a General Hospital in Sancti-Spiritus, Cuba.Results: Between 2017 and 2019, 660 patients with AMI were admitted, most of them (72%), presented with features of ST-elevation myocardial infarction. Thrombolytics were administered to 268 (72.4%) patients, 43 (16%) of them in less than 30 minutes after diagnosis. Double antiplatelet treatment was administered to 98.1% of patients at admission. However, only 163 (34.8%) were enrolled in secondary prevention programs. No information regarding Patient Experience, nor 30-day adjusted mortality, was collected. Secondary prevention was fulfilled around 90%Conclusion: Determination of the quality metrics brought some improvement for the perception of the actual quality of care in this low/middle income scenario. Pre-hospital quality markers need to be improved, before trying to introduce a higher level of treatment.
Mesenchymal Stem Cells Desensitize Castration-resistant Prostate Cancer to Docetaxel Chemotherapy via Inducing TGF-β1-mediated Cell Autophagy
Authors: Yu Yang , Zhang Wen-tao , Yang Fu-han , Guo Ya-dong , Ye Lin , Yao Xu-dong 
Published: June 2020

Abstract
Background: Mesenchymal stem cells (MSCs) have been proved to accelerate prostate cancer (PCa) castration resistance progression. The purpose of this study is to investigate the contribution of MSCs to the development of docetaxel resistance in castration-resistant prostate cancer (CRPC) cells and its potential mechanisms.Methods: The effect of MSCs on CRPC cells resistance to docetaxel was determined using in-vivo and in-vitro approaches. CCK8 and PI/Annexin V-FITC assay were used to examined the cell viability and apoptosis. The concentration of transforming growth factor-β1 was measured by enzyme-linked immunosorbent assay and small interfering RNA was used for functional analyses.Results: MSCs significantly reduced the sensitivity of CRPC cells to docetaxel-induced proliferation inhibition and apoptosis promotion in vivo and in vitro. CRPC cells cocultured with MSCs under docetaxel administration have an increased autophagy activation, while autophagy inhibitor could effectively reversed MSCs-induced resistance to docetaxel. Additionally, MSCs-induced CRPC cell autophagy increase under docetaxel administration depends on MSCs secreting TGF-β1 and inhibition of TGF-β1 secretion in MSCs could consequently increase the sensitivity of CRPC cells to docetaxel.Conclusions: These results suggest that docetaxel administrated CRPC cells may elicit MSCs secreting TGF-β1 increase, which desensitizes CRPC to docetaxel chemotherapy accelerating chemoresistance occurrence via inducing cell autophagy.
Preoperative Internal Medicine Evaluation Reduces 30-Day Postoperative Mortality Risk in Patients with Cancer
Authors: Soones Tacara , Guo Anna , Foreman Jessica T. , Leung Cheuk Hong , Lin Heather Y. , Popovich Shannon , Sahai Sunil K. , Hwang Jessica P. 
Published: June 2020

Abstract
Background

The effect of preoperative internal medicine evaluations on cancer patients undergoing surgery is uncertain.
Methods

We conducted a retrospective cohort study of cancer patients who had been included in the National Surgery Quality Improvement Program from 2011–2014 to determine the effect of an Internal Medicine Perioperative Assessment Center (IMPAC) evaluation on the risk of 30-day mortality compared to that of patients who proceeded directly to surgery.
Results

Of the 11,577 participants, 3589 underwent an IMPAC evaluation. Among the propensity score-matched cohorts, the odds ratio (OR) of 30-day mortality was .39 (95% CI = .18-.84).
Conclusions

Our findings demonstrate that a preoperative internal medicine evaluation was associated with lower 30-day mortality.
Changes in the use of Otorhinolaryngology Emergency Department during the COVID-19 pandemic: report from Lombardy, Italy
Authors: Elli Fabrizia , Zanoni Mario Turri , Arosio Alberto Daniele , Karligkiotis Apostolos , Battaglia Paolo , Castelnuovo Paolo 
Published: June 2020

Abstract
Purpose. This paper aims to report the impact of COVID-19 outbreak on Emergency Ear nose and Throat (ENT) activity, in Lombardy (Italy), during COVID-19 pandemic.Methods. The number of accesses to Emergency Department requiring ENT consultations between February 21st and May 7th, 2020, was retrospectively collected, along with the conditions treated. Data were stratified in one-week time spans, in order to evaluate the evolving trends during the on-going epidemic and a comparison with the two previous years was performed. Results. A significant reduction in the number of consultations performed during the pandemic was observed, as high as - 91% compared to the same period of 2018. Conclusion. Multiple reasons can explain such a reduction of Emergency ENT consultations, not least the fear of potentially being infected by SARS-Cov-2 by while accessing the hospital. The analysis performed might be useful as a starting point for a future reorganization of first aid consultations once the epidemic will be resolved.
Screening and Identification of Key Biomarkers in Gastric Cancer: Three Genes Jointly Predict Gastric Cancer
Authors: Shan Meng-jie , Meng Ling-bing , Guo Peng , Liu Ya-bin 
Published: June 2020

Abstract
Background: Gastric cancer (GC) is the fifth most common cancer in the world and the second leading cause of cancer death. Gastric cancer screening is one of the effective strategies to reduce the mortality. If we use gastric cancer biomarkers with good clinical effect instead of gastroscopy screening, it can achieve early detection, early diagnosis, early treatment. Methods: We download four gene expression profiling datasets of gastric cancer (GSE118916, GSE54129, GSE103236, GSE112369), which obtained from the Gene Expression Omnibus (GEO) database. The DEGs between gastric cancer and adjacent normal tissues were detect to explore genes that may play a key role in gastric cancer. GO and KEGG analyses of overlap genes were performed by the Metascape online database, the protein-protein interaction (PPI) network was analyzed by the STRING online database, and we obtained the hub genes of PPI network via using the Cytoscape software. The survival curve analysis was performed by km-plotter and the stage plots of hub genes was performed by the GEPIA online database. We selected CDH3, LEF1 and MMP7 as candidate biomarkers to construct a back propagation neural network model. Results: This study shows that MMP7, CDH3 and LEF1 are highly expressed in gastric cancer tissues. Conclusions: The joint prediction of the MMP7, CDH3 and LEF1 is helpful for the early diagnosis of cancer.