bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cosmology with the submillimetre galaxies magnification bias: Proof of concept
Authors: Bonavera L. , González-Nuevo J. , Cueli M. M. , Ronconi T. , Migliaccio M. , Dunne L. , Lapi A. , Maddox S. J. , Negrello M. 
Published: June 2020

Context. As recently demonstrated, high-z submillimetre galaxies (SMGs) are the perfect background sample for tracing the mass density profiles of galaxies and clusters (baryonic and dark matter) and their time-evolution through gravitational lensing. Their magnification bias, a weak gravitational lensing effect, is a powerful tool for constraining the free parameters of a halo occupation distribution (HOD) model and potentially also some of the main cosmological parameters.
Aims. The aim of this work is to test the capability of the magnification bias produced on high-z SMGs as a cosmological probe. We exploit cross-correlation data to constrain not only astrophysical parameters (Mmin, M1, and α), but also some of the cosmological ones (Ωm, σ8, and H0) for this proof of concept.
Methods. The measured cross-correlation function between a foreground sample of GAMA galaxies with spectroscopic redshifts in the range 0.2 < z < 0.8 and a background sample of H-ATLAS galaxies with photometric redshifts > 1.2 is modelled using the traditional halo model description that depends on HOD and cosmological parameters. These parameters are then estimated by performing a Markov chain Monte Carlo analysis using different sets of priors to test the robustness of the results and to study the performance of this novel observable with the current set of data.
Results. With our current results, Ωm and H0 cannot be well constrained. However, we can set a lower limit of > 0.24 at 95% confidence level (CL) on Ωm and we see a slight trend towards H0 >  70 values. For our constraints on σ8 we obtain only a tentative peak around 0.75, but an interesting upper limit of σ8 ≲ 1 at 95% CL. We also study the possibility to derive better constraints by imposing more restrictive priors on the astrophysical parameters.
Asteroid (16) Psyche’s primordial shape: A possible Jacobi ellipsoid
Authors: Ferrais M. , Vernazza P. , Jorda L. , Rambaux N. , Hanuš J. , Carry B. , Marchis F. , Marsset M. , Viikinkoski M. , Brož M. , Fetick R. , Drouard A. , Fusco T. , Birlan M. , Podlewska-Gaca E. , Jehin E. , Bartczak P. , Berthier J. , Castillo-Rogez J. , Cipriani F. , Colas F. , Dudziński G. , Dumas C. , Ďurech J. , Kaasalainen M. , Kryszczynska A. , Lamy P. , Le Coroller H. , Marciniak A. , Michalowski T. , Michel P. , Santana-Ros T. , Tanga P. , Vachier F. , Vigan A. , Witasse O. , Yang B. 
Published: June 2020

Context. Asteroid (16) Psyche is the largest M-type asteroid in the main belt and the target of the NASA Psyche mission. It is also the only asteroid of this size (D >  200 km) known to be metal rich. Although various hypotheses have been proposed to explain the rather unique physical properties of this asteroid, a perfect understanding of its formation and bulk composition is still missing.
Aims. We aim to refine the shape and bulk density of (16) Psyche and to perform a thorough analysis of its shape to better constrain possible formation scenarios and the structure of its interior.
Methods. We obtained disk-resolved VLT/SPHERE/ZIMPOL images acquired within our ESO large program (ID 199.C-0074), which complement similar data obtained in 2018. Both data sets offer a complete coverage of Psyche’s surface. These images were used to reconstruct the three-dimensional (3D) shape of Psyche with two independent shape modeling algorithms (MPCD and ADAM). A shape analysis was subsequently performed, including a comparison with equilibrium figures and the identification of mass deficit regions.
Results. Our 3D shape along with existing mass estimates imply a density of 4.20  ±  0.60 g cm−3, which is so far the highest for a solar system object following the four telluric planets. Furthermore, the shape of Psyche presents small deviations from an ellipsoid, that is, prominently three large depressions along its equator. The flatness and density of Psyche are compatible with a formation at hydrostatic equilibrium as a Jacobi ellipsoid with a shorter rotation period of ∼3h. Later impacts may have slowed down Psyche’s rotation, which is currently ∼4.2 h, while also creating the imaged depressions.
Conclusions. Our results open the possibility that Psyche acquired its primordial shape either after a giant impact while its interior was already frozen or while its interior was still molten owing to the decay of the short-lived radionuclide 26Al.
Sequenztherapie beim nicht oder mild symptomatischen metastasierten kastrationsresistenten Prostatakarzinom
Authors: Miller Kurt 
Published: June 2020

ZusammenfassungBeim nicht oder mild symptomatischen metastasierten kastrationsresistenten Prostatakarzinom (mCRPC) können sowohl die modernen antihormonellen Wirkstoffe Abirateronacetat plus Prednison/Prednisolon (Abirateron/P) und Enzalutamid als auch eine Chemotherapie mit Docetaxel zum Einsatz kommen. Da die Behandlung mit Docetaxel teils ausgeprägte Nebenwirkungen haben kann, ist eine wichtige Therapiealternative die insgesamt besser verträgliche antihormonelle Therapie. Neben der Wirksamkeit und Verträglichkeit kann bei der Wahl der mCRPC-Erstlinientherapie zudem der Einfluss auf die Wirksamkeit von Folgetherapien eine wichtige Rolle spielen. Bisher lagen nur retrospektive Studien zum sequenziellen Einsatz von Abirateron/P und Enzalutamid bei dieser Indikation vor. In einer prospektiven, randomisierten Phase-II-Studie der British Columbia Cancer Agency (BCCA) wurden Abirateron/P und Enzalutamid nun erstmals bez. ihrer Wirksamkeit und Verträglichkeit in der Erstlinientherapie des nicht oder mild symptomatischen mCRPC sowie der Folgetherapie miteinander verglichen.
Das Behandlungsprogramm bei Adipositas mit den Schwerpunkten Essverhalten und Lebensstiländerung (BASEL) ist effektiv, aber nicht kostendeckend
Authors: Goetschmann Mara , Nickolai Beate , Hegar Karin , Fäh David , Kiss Caroline 
Published: June 2020

Zusammenfassung
Hintergründe Gruppenprogramme zur Adipositastherapie unter Alltagsbedingungen sind wenig untersucht. Diese Studie analysiert das interprofessionelle Behandlungsprogramm bei Adipositas mit den Schwerpunkten Ernährungsverhalten und Lebensstiländerung (BASEL) bezüglich Effektivität und betrieblicher Wirtschaftlichkeit.
Material und Methodik Retrospektive Untersuchung der Gewichtsentwicklung von Programmstart bis Programmende sowie bis zum Nachtreffen. Analyse der Zusammenhänge zwischen einer Gewichtsreduktion ≥ 5 % und weiteren Faktoren durch eine multivariate logistische Regression. Zusätzlich erfolgte eine Kostenanalyse.
Ergebnisse Die 454 Teilnehmenden hatten ein mittleres Ausgangsgewicht von 114 kg (68–195 kg), BMI 40 kg/m2 (25,2–63,7), waren 46 Jahre (17–75) und mehrheitlich Frauen (72 %). Bei Programmende lag die mittlere Gewichtsreduktion bei 4,9 % (SD ± 4,2 %) (44,3 % erreichten Reduktion ≥ 5 %; 11,5 % erreichten Reduktion ≥ 10 %). Beim Nachtreffen (n = 256) betrug die Reduktion 7 % (SD ± 6,4 %) (33,5 % erreichten Reduktion ≥ 5 %; 16,7 % erreichten Reduktion ≥ 10 %). Personen, die ≥ 75 % der Lektionen und das Nachtreffen besuchten, hatten bei Programmende eine 3,8-mal höhere Chance zur erfolgreichen Gewichtsreduktion (≥ 5 %), als Personen, die < 75 % der Lektionen besuchten und nicht zum Nachtreffen erschienen (p = < 0,001). Der Kostendeckungsgrad des Programms lag bei 66 %.
Schlussfolgerung Das BASEL ist ein effektives Adipositas-Behandlungsprogramm, wobei die regelmäßige Teilnahme mit einem besseren Therapieerfolg assoziiert war. Über die Hälfte der Personen mit hoher Teilnahmerate erzielten eine klinisch relevante Gewichtsreduktion von ≥ 5 %. Das Programm ist aufgrund tiefer Gruppentarife der Krankenversicherer in der Schweiz für Anbieter nicht kostendeckend.
Endoscopic treatment of Zenkerʼs diverticulum by complete septotomy: initial experience in 19 patients
Authors: Juin Charlotte , Barret Maximilien , Belle Arthur , Abouali Einas , Leblanc Sarah , Oudjit Ammar , Dohan Anthony , Coriat Romain , Chaussade Stanislas 
Published: June 2020

Abstract
Background and study aims Endoscopic treatment of Zenker’s Diverticulum (ZD) using a flexible endoscope and a diverticuloscope consists of myotomy of the cricopharyngeus muscle, sparing the lower part of the diverticular septum. However, recurrence occurs in up to 54 % of patients at 4 years. We assessed the feasibility and safety of a complete septotomy in endoscopic treatment of ZD.
Patients and methods We conducted a retrospective analysis of a prospectively collected database at a single referral center. All consecutive patients treated by complete resection of the diverticular wall were included. The endoscopic technique used a distal attachment cap and division of the ZD septum using a Dual Knife or a Triangle Tip knife in endocut mode, until the esophageal muscularis propria was seen and no residual diverticulum remained. Symptoms were evaluated using the Augsburger questionnaire.
Results Nineteen patients, 10 of whom were men with mean age 79 ± 12 years, were treated by complete septotomy for a symptomatic ZD with a median size of 2.5 cm (range 1–5 cm). The clinical success rate was 100 % and the complication rate was 10 % (one pneumonia and one atrial fibrillation). Median hospital stay was 2 days (range 1–3 days). On Day 1 esophagogram, no extraesophageal contrast leakage was seen, periesophageal CO2 was still visible in two patients, and complete ZD regression was seen in 63 % of patients. The 6-month clinical success rate was 100 %, with two patients lost to follow-up, and a median symptom score of 0 (range 0–4). After a mean ± SD follow-up of 9 ± 5 months, the clinical success rate was 94 % (16/17).
Conclusion Complete endoscopic septotomy is a feasible and safe therapeutic modality in patients with symptomatic ZD that does not require use of a diverticuloscope, and with good short-term efficacy. The complete regression of the diverticulum observed on Day 1 in 63 % of patients could be a marker of long-term clinical success.
Magnetresonanztomografie peripherer Gelenke
Authors: Abrar Daniel B. , Sewerin Philipp 
Published: June 2020

ZUSAMMENFASSUNGBildgebende Verfahren nehmen in der Primärdiagnostik, Prognose und Therapiekontrolle einen zunehmenden Stellenwert ein. Insbesondere die Magnetresonanztomografie (MRT) ermöglicht dabei die sensitive und frühe Erkennung akut-entzündlicher (z. B. Synovialitis und Knochenmarködem) und chronisch-struktureller (z. B. Erosionen) Veränderungen im Rahmen peripherer rheumatischer Gelenkerkrankungen. Die steigende Bedeutung wird durch die Etablierung standardisierter, zunehmend vereinfachter Scoring-Systeme unterstrichen, die MRT-Untersuchungen objektivier- und vergleichbar machen. Zudem wird durch den Einsatz innovativer, kompositioneller Methoden die Früherkennung von Knorpelveränderungen und durch dynamische Verfahren die Quantifizierung fokaler Gelenkentzündung ermöglicht.
Leben am Ende? Am Ende Leben! Seelsorge auf der Palliativstation
Authors: Silano Katrin 
Published: June 2020

ZusammenfassungDie Palliativstation wird als Endstation angesehen. Hoffnungslosigkeit, Angst, Trauer und Schmerzen stehen bei Patienten und Angehörigen im Vordergrund. Eines der Prinzipien der Palliativversorgung ist der Aspekt des „Lebens bis zuletzt“. So gibt es auf der Palliativstation schon das Bewusstsein, dass sich die Kranken am Ende ihres Lebens befinden, dass es aber unzählige Möglichkeiten gibt, dieses Ende gut zu gestalten. Unabhängig davon, ob Patienten gläubig, zweifelnd oder ungläubig sind, hat jeder am Ende seines Lebens etwas zu erzählen, möchte Unterdrücktes aussprechen, Versöhnungen anstreben, Bereutes aufarbeiten oder gar Sünden vergeben bekommen. Die Seelsorge versucht diesen Spagat zu leisten.
Konsensusempfehlung zur strukturierten Befunderstellung onkologischer PET-Hybridbildgebung
Authors:   Autoren,   Vorstand der Interdisziplinären AG für Hybride Bildgebung in alphabetischer Reihenfolge:,   Vorstand der Deutschen Röntgengesellschaft (DRG) und der Deutschen Gesellschaft für Nuklearmedizin (DGN) in alphabetischer Reihenfolge:
Published: June 2020

ZusammenfassungSeit Einführung der PET/CT im Jahr 2001 bzw. der PET/MRT im Jahr 2010 ist die PET als Hybridbildgebung und Instrument einer bildgesteuerten Präzisionsmedizin zunehmend zu einem Versorgungsstandard in der Onkologie geworden. Die zentrale Schnittstelle in der Kommunikation zwischen den zuweisenden onkologisch tätigen Ärzten und dem Nuklearmediziner und Radiologen stellt der schriftliche Befund dar, der das Patientenmanagement und Outcome beeinflusst, aber auch juristisch-relevante Dokumentation der erbrachten Leistung und ärztlichen Beurteilung der erhobenen Befunde ist. Eine qualitativ hochwertige, auf die klinische Frage fokussierte Hybridbildgebung sollte im weiteren Fortgang mit einem gleichermaßen qualitativ hochwertigen, strukturierten schriftlichen Befund verbunden sein, der die klinische Frage zur Zufriedenheit des zuweisenden Arztes beantwortet. Im vorliegenden Manuskript werden daher Konsensempfehlungen zur Befundstruktur, zu Befundinhalten und zur konklusiven Beurteilung einer onkologischen Hybridbildgebung gegeben. Darüber hinaus werden beispielhafte Vorlagen für ebensolche Befunde dargestellt. Die hier dargelegten Empfehlungen zur strukturierten Befunderstellung sollen eine weitere Standardisierung und Harmonisierung onkologischer Befunde im Kontext einer Hybridbildgebung fördern und so die Kommunikation mit den zuweisenden Ärzten vereinfachen und die Akzeptanz und Wertschätzung der onkologischen Hybridbildgebung weiter unterstützen.
Multimodality Management of Ruptured Large Hepatocellular Carcinoma and Its Recurrence: Rupture at Presentation Should Not Rupture Hope of Long-Term Survival
Authors: Desai Gunjan S. , Pande Prasad M. , Narkhede Rajvilas A. , Wagle Prasad K. 
Published: June 2020

AbstractA 59-year-old gentleman with a history of aortic valve replacement presented with spontaneously ruptured hepatocellular carcinoma in right lobe of a hepatitis C virus (HCV)-related chronic liver disease with hemoperitoneum. This acute emergency was managed by transarterial embolization. Right trisectionectomy with preservation of segment IVB after augmentation of future liver remnant by transarterial chemoembolization followed by portal vein embolization was subsequently performed. Sustained virological response to HCV was attained after surgery using sofosbuvir-based regimen. He had a delayed operative bed recurrence 1.5 years later with pulmonary metastatic disease which was managed by operative bed metastasectomy with mesh reconstruction of diaphragm and sorafenib. He is on sorafenib since past 3 years and doing well at 4.5-years follow-up since the first presentation, with significant regression of pulmonary disease and no other disease elsewhere, which highlights that where there is hope, there is a way.
Endovascular Treatment of Intracranial Pial–Dural Arteriovenous Fistula: A Case Report
Authors: Shchehlov D. V. , Konotopchyk S. V. , Svyrydiuk O. E. , Bortnik I. M. , Momonova M.Y. , Vyval M.B. 
Published: June 2020

AbstractIntracranial pial arteriovenous fistula (PAVF) is a rare cerebrovascular pathology characterized by abnormal direct high-flow connection between the pial or cortical feeding artery and draining vein. Dural arteriovenous fistula (DAVF) is a pathological shunt between the meningeal arteries and dural sinuses or meningeal veins. In case of association between PAVF and DAVF, diagnosis and treatment are more challenging. The high-flow arteriovenous shunt and deep venous drainage make PAVF more preferable for endovascular treatment; however, their embolization during single-session procedures can lead to extensive thrombosis of the draining veins and unfavorable outcomes. We present a case report of endovascular embolization of an intracranial PAVF–DAVF in a 2.5-year-old child. At the time of admission, the patient had hydrocephalus, mental retardation, pyramidal insufficiency, and seizures. Occlusion of the fistula was performed during two stages of embolization to reduce the risk of severe venous stasis and venous thrombosis. Guglielmi detachable coils (GDCs) and a liquid embolic agent (Histoacryl with Lipiodol) were used for embolization. The patient recovered well after the procedure, with significant mental improvement. This suggests that the deployment of GDCs in the afferent artery near a fistula before embolization with a liquid embolic agent can minimize the risk of uncontrolled penetration of the embolization into the draining veins and dural sinus. A multisession procedure can be an effective and reasonable method of PAVF and DAVF occlusion among existing treatment options.
Computed Tomography Evaluation of Craniovertebral Junction in Asymptomatic Central Rural Indian Population
Authors: Gupta Prasheelkumar Premnarayan , Dhok Atul Manohar , Shaikh Salman T. , Patil Akshay Shrirang , Gupta Deepak , Jagdhane Nitin Nandkumar 
Published: June 2020

Abstract

Objectives Craniovertebral junction (CVJ) is a unique, mobile and complicated component of our spine which necessitates specific study pertaining to its structure as well as pathologies. This study aims to report the normative data detailing the CVJ anatomy among the rural population of Central India which would help us in understanding the joint dynamics.

Materials and Methods A retrospective observational study was undertaken in the Department of Neurosurgery and Radiology, Mahatma Gandhi Institute of Medical Sciences, Sewagram, Maharashtra, from December 2018 to May 2019. A total of 255 head injury patients with a normal CT brain cervical spine were included in this study. Anterior and posterior atlantodental interval (AADI/PADI), clivus length (CL), foramen magnum diameter (FMD), Boogard’s and basal angle (BOO & BA) were measured and analyzed.

Statistical Analysis Statistical analysis was done using Microsoft Excel 2016. A web-based, open source application known as OpenEpi.com (version 3.01) was used for applying unpaired t-test.

Results This study had a mean age of 42.9 years. The difference in mean value of AADI between male and female population was not found to be statistically significant, while in case of PADI, CL, FMD, BOO and BA, it was found to be significant (p < 0.05). On comparison of cases with age ≤ 20 years and > 20 years, we found the difference in values of ADI, CL and FMD to be statistically significant (p < 0.05).

Conclusion Although there are some similarities, namely, AADI measurements as compared with other studies, there are differences in cutoff values of other parameters. Being a major draining reference center for rural population in India, this data can be extrapolated to a similar population for reference.
Variation in Electronic Health Record Workflow Patterns: A Multisite study
Authors: Kandaswamy Swaminathan , Wei Jiajun , Will Amy , Savage Erica , Ratwani Raj M. , Hettinger Aaron Z. , Miller Kristen 
Published: June 2020

Abstract
Objectives Electronic health records (EHRs) continue to have significant usability challenges in part due to differences in workflow. The objective of this study was to examine workflow pattern variations for one specific task: emergency physicians placing a magnetic resonance imaging (MRI) order.
Methods A between-subjects usability study was conducted using two different major EHR vendor products across four different provider sites (n = 55). A clinical scenario concerning for spinal cord compression was read to participants who then completed an ordering task using a training environment representative of their native EHR. The primary outcome measures were accuracy, time on task, and number of clicks.
Results We identified four different workflows to complete the same order. One workflow required two steps (enabled at one site), one workflow required four steps (enabled at two sites), and two workflows required six steps to complete the task (available at all sites). Of the 12 physicians who employed the two-step workflow, 8 (67%) had the correct order and correct indication, the average time on task was 29.65 (standard deviation [SD] = 13.77), and the mean number of clicks was 13.5 (SD = 18.87). In contrast, for the 43 physicians who employed other workflows, 7 (21%) had the correct order and correct indication, with the average time on task of 73.1 (SD = 30.12) and mean clicks of 27.64 (SD = 13.25) (p < 0.01 for all three comparisons).
Discussion These different approaches were made possible by technical specifications leading to multiple workflow options available to physicians in the EHR environment. EHR design maximizing usability can reduce the work effort and improve the accuracy of physician ordering.
The Importance of Staging Arthroscopy for Chondral Defects of the Knee
Authors: Salem Hytham S. , Chaudhry Zaira S. , Lucenti Ludovico , Tucker Bradford S. , Freedman Kevin B. 
Published: June 2020

AbstractThis study aims to evaluate the role of staging arthroscopy in the diagnosis of knee chondral defects and subsequent surgical planning prior to autologous chondrocyte implantation (ACI), osteochondral allograft transplantation (OCA), and meniscus allograft transplantation (MAT). All patients who underwent staging arthroscopy prior to ACI, OCA, or MAT at our institution from 2005 to 2015 were identified. Medical records were reviewed to document the diagnosis and treatment plan based on symptoms, magnetic resonance imaging (MRI) findings and previous operative records. Operative records of the subsequent staging arthroscopy procedure were reviewed to document the proposed treatment plan after arthroscopy. All changes in treatment plan following staging arthroscopy were recorded. Univariate analyses were performed to identify any significant predictors for likelihood to change. A total of 98 patients were included in our analysis. A change in surgical plan was made following arthroscopy in 36 patients (36.7%). Fourteen patients (14.3%) were found to have additional defects that warranted cartilage restoration surgery. In 15 patients (15.3%), at least one defect that was originally thought to warrant cartilage restoration surgery was found to be amenable to debridement alone. The surgical plan was changed from ACI to OCA in four cases (4.1%) and OCA to ACI in one case (1%). A previously proposed MAT was deemed unwarranted in one case (1%), and a planned meniscal repair was changed to MAT in another (1%). Patient age, sex, and the affected knee compartment were not predictors for a change in surgical plan. Body mass index (BMI) was significantly higher in patients who had a change in surgical plan (29.5 kg/m2) compared with those who did not (26.5 kg/m2). A change in surgical plan was more likely to occur for trochlear lesions (46.4%) compared with other articular surface lesions (p = 0.008). The results of our study indicate that staging arthroscopy is an important step in determining the most appropriate treatment plan for chondral defects and meniscal deficiency, particularly those with trochlear cartilage lesions.