bluuebunny/crossref_metadata_2025_split huggingface dataset:
Displacement in root apex and changes in incisor inclination affect alveolar bone remodeling in adult bimaxillary protrusion patients: a retrospective study
Authors: Mao Huimin , Yang Andi , Pan Yue , Li Houxuan , Lei Lang 
Published: November 2020

Abstract
Background
Periodontal health is of great concern for periodontists and orthodontists in the inter-disciplinary management of patients with bimaxillary protrusion. The aim of present study is to investigate changes in the alveolar bone in the maxillary incisor region and to explore its relationship with displacement of root apex as well as changes in the inclination of maxillary incisors during incisor retraction.

Methods
Samples in this retrospective study consisted of 38 patients with bimaxillary protrusion. Cone-beam computed tomography (CBCT) images was taken before(T0) and after (T1) treatment. Alveolar bone thickness (ABT), height (ABH) and area (ABA) were utilized to evaluate changes in the alveolar bone, while incisor inclination and apex displacement were used to assess changes in the position of maxillary central and lateral incisors. Correlations between alveolar bone remodeling and apex displacement as well as changes in the inclination were investigated.

Results
The labial ABT of central and lateral incisors at the mid-root third was increased. In contrast, the palatal ABT at crestal, mid-root and apical third level were consistently decreased. ABH was not altered on the labial side, while significantly decreased on the palatal side. ABA was not significantly increased on the labial side, but significantly decreased on the palatal side, leading to a significantly reduced total ABA. Orthodontic treatment significantly reduced inclination of upper incisors. Changes in the amount (T1-T0) of ABA was remarkably correlated with apex displacement and changes of inclination (T1-T0); in addition, using the multivariate linear regression analysis, changes of ABA on the palatal side (T1-T0) can be described by following equation: Changes of palatal ABA (T1-T0) = − 3.258- 0.139× changes of inclination (T1-T0) + 2.533 × apex displacement (T1-T0).

Conclusions
Retraction of incisors in bimaxillary protrusion patients may compromise periodontal bone support on the palatal side. An equation that incorporated the displacement of root apex and change in the incisor inclination may enable periodontist-orthodontist interdisciplinary coordination in assessing treatment risks and developing an individualized treatment plan for adult patients with bimaxillary protrusion. Moreover, the equation in predicating area of alveolar bone may reduce the risks of placing the teeth out of the bone boundary during 3D digital setups.
Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities
Authors: Mehtonen Juha , Teppo Susanna , Lahnalampi Mari , Kokko Aleksi , Kaukonen Riina , Oksa Laura , Bouvy-Liivrand Maria , Malyukova Alena , Mäkinen Artturi , Laukkanen Saara , Mäkinen Petri I. , Rounioja Samuli , Ruusuvuori Pekka , Sangfelt Olle , Lund Riikka , Lönnberg Tapio , Lohi Olli , Heinäniemi Merja 
Published: November 2020

AbstractBackgroundTight regulatory loops orchestrate commitment to B cell fate within bone marrow. Genetic lesions in this gene regulatory network underlie the emergence of the most common childhood cancer, acute lymphoblastic leukemia (ALL). The initial genetic hits, including the common translocation that fusesETV6andRUNX1genes, lead to arrested cell differentiation. Here, we aimed to characterize transcription factor activities along the B-lineage differentiation trajectory as a reference to characterize the aberrant cell states present in leukemic bone marrow, and to identify those transcription factors that maintain cancer-specific cell states for more precise therapeutic intervention.MethodsWe compared normal B-lineage differentiation and in vivo leukemic cell states using single cell RNA-sequencing (scRNA-seq) and several complementary genomics profiles. Based on statistical tools for scRNA-seq, we benchmarked a workflow to resolve transcription factor activities and gene expression distribution changes in healthy bone marrow lymphoid cell states. We compared these to ALL bone marrow at diagnosis and in vivo during chemotherapy, focusing on leukemias carrying theETV6-RUNX1fusion.ResultsWe show that lymphoid cell transcription factor activities uncovered from bone marrow scRNA-seq have high correspondence with independent ATAC- and ChIP-seq data. Using this comprehensive reference for regulatory factors coordinating B-lineage differentiation, our analysis ofETV6-RUNX1-positive ALL cases revealed elevated activity of multiple ETS-transcription factors in leukemic cells states, including the leukemia genome-wide association study hit ELK3. The accompanying gene expression changes associated with natural killer cell inactivation and depletion in the leukemic immune microenvironment. Moreover, our results suggest that the abundance of G1 cell cycle state at diagnosis and lack of differentiation-associated regulatory network changes during induction chemotherapy represent features of chemoresistance. To target the leukemic regulatory program and thereby overcome treatment resistance, we show that inhibition of ETS-transcription factors reduced cell viability and resolved pathways contributing to this using scRNA-seq.ConclusionsOur data provide a detailed picture of the transcription factor activities characterizing both normal B-lineage differentiation and those acquired in leukemic bone marrow and provide a rational basis for new treatment strategies targeting the immune microenvironment and the active regulatory network in leukemia.
Potential of deep predictive coding networks for spatiotemporal tsunami wavefield prediction
Authors: Fauzi Ardiansyah , Mizutani Norimi 
Published: November 2020

AbstractData assimilation is a powerful tool for directly forecasting tsunami wavefields from the waveforms recorded at dense observational stations like S-Net without the need to know the earthquake source parameters. However, this method requires a high computational load and a quick warning is essential when a tsunami threat is near. We propose a new approach based on a deep predictive coding network for forecasting spatiotemporal tsunami wavefields. Unlike the previous data assimilation method, which continuously computes the wavefield when observed data are available, we use only a short sequence from previously assimilated wavefields to forecast the future wavefield. Since the predictions are computed through matrix multiplication, the future wavefield can be estimated in seconds. We apply the proposed method to simple bathymetry and the 2011 Tohoku tsunami. The results show that our proposed method is very fast (1.6 s for 32 frames of prediction with 1-min interval) and comparable to the previous data assimilation. Therefore, the proposed method is promising for integration with data assimilation to reduce the computational cost.
Stationarity of spot freight rates considering supply/demand effect
Authors: Hayashi Koichiro 
Published: November 2020

AbstractThe mean-reverting nature of freight rates is one of the important subjects in maritime economics. The classic understanding of maritime economics (and that of the shipping industry) suggests that freight rate processes are mean-reverting and approach the level decided by the demand/supply ratio. However, statistical tests on freight rate processes often reveal these processes to be non-stationary, which means the processes would not have a mean-reverting nature. In this study, we investigated the mean-reverting nature of Panamax freight rates (Baltic Panamax 4 T/C Average) for two “means”: the actual freight rate process itself, and the deviation process of actual freight rates from estimated ones based on the demand/supply ratio. The AR (1) model can be applied to both processes, and their autoregressive coefficient φ was between 0 and 1. In the actual freight process, φ was close to 1, and a unit root test failed to reject that the process is non-stationary. By contrast, in the deviation process, φ was sufficiently smaller than 1, and a unit root test rejected that the process is non-stationary. The result can resolve the contradiction between two views on mean-reverting nature; if we focus on the actual freight rate process itself and do not consider demand/supply, the process is non-stationary and does not have a mean-reverting nature. If we focus on the deviation process of the actual freight rates from the level decided by the demand/supply ratio, the process is stationary and tends to approach zero.
Modeling of moral decisions with deep learning
Authors: Wiedeman Christopher , Wang Ge , Kruger Uwe 
Published: November 2020

AbstractOne example of an artificial intelligence ethical dilemma is the autonomous vehicle situation presented by Massachusetts Institute of Technology researchers in the Moral Machine Experiment. To solve such dilemmas, the MIT researchers used a classic statistical method known as the hierarchical Bayesian (HB) model. This paper builds upon previous work for modeling moral decision making, applies a deep learning method to learn human ethics in this context, and compares it to the HB approach. These methods were tested to predict moral decisions of simulated populations of Moral Machine participants. Overall, test results indicate that deep neural networks can be effective in learning the group morality of a population through observation, and outperform the Bayesian model in the cases of model mismatches.
Reduction of coercive measures under routine conditions in psychiatric hospitals 2004–2019: Strong effects in old age psychiatry, much less in general psychiatry
Authors: Steinert Tilman , Hirsch Sophie , Goebel Rita , Snellgrove Brendan , Flammer Erich 
Published: November 2020

Abstract

Background
Many interventions to reduce the use of seclusion and restraint have been suggested in the last decades. Evidence-based interventions in old age psychiatry are different from those in general psychiatry. A common database for psychiatric hospitals introduced in 2004 allowed to examine the use of seclusion and restraint over 16 years under routine conditions.

Methods
A registry for coercive measures in the Federal State of Baden-Wuerttemberg has been available since 2015, and comprises all 32 hospitals licensed to admit involuntary patients. A study group had collected data prospectively since 2004 from a subsample of these hospitals. We analyzed the mean percentage of patients subjected to coercive measures and the mean cumulative duration of these interventions in ICD-10 diagnostic groups in psychiatric hospitals from 2004 to 2019 among a total of 1,038,239 admissions.

Results
The proportion of cases affected by coercive measures dropped significantly from 28.4 to 10.5% in patients with ICD-10 F0 disorders, while rates in patients with other diagnoses decreased insignificantly from 7.0 to 5.4%. The cumulated duration of coercive measures per affected case also dropped significantly among patients with F0 disorders, while changes in patients with other diagnoses remained insiginficant.

Conclusions
The use of coercive measures in patients with organic disorders could be reduced by about 50% in a State of 11 million inhabitants within 15 years, while in contrast no substantial reduction occurred among all other diagnostic groups. Specific interventions to reduce coercive interventions seem to be particularly successful for this patient group.
Impact of High-Dose-Rate Brachytherapy Training via Telehealth in Low- and Middle-Income Countries
Authors: Hatcher Jeremy B. , Oladeru Oluwadamilola , Chang Betty , Malhotra Sameeksha , Mcleod Megan , Shulman Adam , Dempsey Claire , Mula-Hussain Layth , Tassoto Michael , Sandwall Peter , Dieterich Sonja , Sulieman Lina , Roa Dante , Li Benjamin 
Published: November 2020

PURPOSE Our objective was to demonstrate the efficacy of a telehealth training course on high-dose-rate (HDR) brachytherapy for gynecologic cancer treatment for clinicians in low- and middle-income countries (LMICs) METHODS A 12-week course consisting of 16 live video sessions was offered to 10 cancer centers in the Middle East, Africa, and Nepal. A total of 46 participants joined the course, and 22 participants, on average, attended each session. Radiation oncologists and medical physicists from 11 US and international institutions prepared and provided lectures for each topic covered in the course. Confidence surveys of 15 practical competencies were administered to participants before and after the course. Competencies focused on HDR commissioning, shielding, treatment planning, radiobiology, and applicators. Pre- and post-program surveys of provider confidence, measured by 5-point Likert scale, were administered and compared. RESULTS Forty-six participants, including seven chief medical physicists, 16 senior medical physicists, five radiation oncologists, and three dosimetrists, representing nine countries attended education sessions. Reported confidence scores, both aggregate and paired, demonstrated increases in confidence in all 15 competencies. Post-curriculum score improvement was statistically significant ( P < .05) for paired respondents in 11 of 15 domains. Absolute improvements were largest for confidence in applicator commissioning (2.3 to 3.8, P = .009), treatment planning system commissioning (2.2 to 3.9, P = .0055), and commissioning an HDR machine (2.2 to 4.0, P = .0031). Overall confidence in providing HDR brachytherapy services safely and teaching other providers increased from 3.1 to 3.8 and 3.0 to 3.5, respectively. CONCLUSION A 12-week, low-cost telehealth training program on HDR brachytherapy improved confidence in treatment delivery and teaching for clinicians in 10 participating LMICs.
The Contribution of Transcriptional Coregulators in the Maintenance of β-cell Function and Identity
Authors: Davidson Rebecca K , Kanojia Sukrati , Spaeth Jason M 
Published: November 2020

Abstract
Islet β-cell dysfunction that leads to impaired insulin secretion is a principal source of pathology of diabetes. In type 2 diabetes, this breakdown in β-cell health is associated with compromised islet-enriched transcription factor (TF) activity that disrupts gene expression programs essential for cell function and identity. TF activity is modulated by recruited coregulators that govern activation and/or repression of target gene expression, thereby providing a supporting layer of control. To date, more than 350 coregulators have been discovered that coordinate nucleosome rearrangements, modify histones, and physically bridge general transcriptional machinery to recruited TFs; however, relatively few have been attributed to β-cell function. Here, we will describe recent findings on those coregulators with direct roles in maintaining islet β-cell health and identity and discuss how disruption of coregulator activity is associated with diabetes pathogenesis.
Bias twisting in side-tapered PMF Sagnac loop interferometer for simultaneous measurement of directional torsion and temperature
Authors: Sun Dexue , Liu Xianjin , Wang Fengjuan , Yang Jiuru 
Published: November 2020

The polarization-maintaining fiber-based Sagnac loop interferometer (PSLI) is frequently applied in directional torsion measurement, but may suffer from a large temperature cross talk. In this study, a novel method was proposed for fabrication of side-tapered PSLI by a two-step arc-discharge technique at the splicing point. The energy distribution of the taper region was characterized, and comprehensive tests were performed in terms of torsion and temperature. The experimental results showed that, through bias twisting, the measuring areas were effectively gapped and highly sensitive torsion and temperature responses were gained simultaneously. With a small wavelength shift, the torsion sensitivity reached 13.54 dB/rad in the range from

−

30

to 30 rad/m. Moreover, the temperature sensitivity was found to be

−

1.579

n
m

/

∘

C

, with a near-zero intensity fluctuation. Therefore, the sensor fabricated herein successfully achieves simultaneous measurement of directional torsion and temperature with high sensitivity and ultralow cross talk. The proposed scheme has the merits of practicality, low cost, and ease of operation, and is very promising for multiparameter engineering monitoring.
Generation of a square-shaped pulse in mode-locked fiber lasers with a microfiber-based few-layer Nb2C saturable absorber
Authors: Li Guoru , Yang Lingling , Zhao Ruwei , Wang Feifei , Nie Hongkun , Wang Ruihua , Yang Kejian , Zhang Baitao , He Jingliang 
Published: November 2020

Niobium carbide (

N
b

2

C

), a novel two-dimensional MXene
material, has attracted much attention due to its outstanding
electronic and optical properties. In this work, a microfiber-based
few-layer

N
b

2

C

saturable absorber (SA) is fabricated
by the magnetron sputtering deposition technique. The reverse
saturable absorption (RSA) response of few-layer

N
b

2

C

nanosheets is observed with I-scan
measurements. The square-wave pulses (SWPs) are generated by using the
as-prepared microfiber-based few-layer

N
b

2

C

SA in an erbium-doped fiber laser.
The SWP width increases from 0.33 to 2.061 ns with the single pulse
energy increases linearly up to 0.89 nJ while the amplitude remains as
a constant. In addition, nonlinear polarization rotation mode-locking
fiber lasers with different cavity lengths are constructed to explore
the formation conditions of SWP. Our results indicate that the RSA
effect of the few-layer

N
b

2

C

nanosheets plays a decisive role in
the formation of the SWP.
Compact high-flux hard X-ray source driven by femtosecond mid-infrared pulses at a 1  kHz repetition rate
Authors: Koç Azıze , Hauf Chrıstoph , Woerner Mıchael , von Grafenstein Lorenz , Ueberschaer Dennıs , Bock Martin , Griebner Uwe , Elsaesser Thomas 
Published: November 2020

A novel, to the best of our knowledge, table-top hard X-ray source driven by femtosecond mid-infrared pulses provides 8 keV pulses at a 1 kHz repetition rate with an unprecedented flux of up to

X-ray photons/s. Sub-100 fs pulses at a center wavelength of 5 µm and multi-millijoule energy are generated in a four-stage optical parametric chirped-pulse amplifier and focused onto a thin Cu tape target. Electrons are extracted from the target and accelerated in a vacuum up to 100 keV kinetic energy during the optical cycle; the electrons generate a highly stable

photon flux from the target in a transmission geometry.
Using repeated home-based HIV testing services to reach and diagnose HIV infection among persons who have never tested for HIV, Chókwè health demographic surveillance system, Chókwè district, Mozambique, 2014–2017
Authors: Lin Carol , Casavant Isabelle , Jaramillo Alicia , Green Timothy 
Published: November 2020

Background
HIV prevalence in Mozambique (12.6%) is one of the highest in the world, yet ~40% of people living with HIV (PLHIV) do not know their HIV status. Strategies to increase HIV testing uptake and diagnosis among PLHIV are urgently needed. Home-based HIV testing services (HBHTS) have been evaluated primarily as a 1-time campaign strategy. Little is known about the potential of repeating HBHTS to diagnose HIV infection among persons who have never been tested (NTs), nor about factors/reasons associated with never testing in a generalized epidemic setting.

Methods
During 2014–2017, counselors visited all households annually in the Chókwè Health and Demographic Surveillance System (CHDSS) and offered HBHTS. Cross-sectional surveys were administered to randomly selected 10% or 20% samples of CHDSS households with participants aged 15–59 years before HBHTS were conducted during the visit. Descriptive statistics and logistic regression were used to assess the proportion of NTs, factors/reasons associated with never having been tested, HBHTS acceptance, and HIV-positive diagnosis among NTs.

Results
The proportion of NTs decreased from 25% (95% confidence interval [CI]:23%–26%) during 2014 to 12% (95% CI:11% –13%), 7% (95% CI:6%–8%), and 7% (95% CI:6%–8%) during 2015, 2016, and 2017, respectively. Adolescent boys and girls and adult men were more likely than adult women to be NTs. In each of the four years, the majority of NTs (87%–90%) accepted HBHTS. HIV-positive yield among NTs subsequently accepting HBHTS was highest (13%, 95% CI:10%–15%) during 2014 and gradually reduced to 11% (95% CI:8%–15%), 9% (95% CI:6%–12%), and 2% (95% CI:0%–4%) during 2015, 2016, and 2017, respectively.

Conclusions
Repeated HBHTS was helpful in increasing HIV testing coverage and identifying PLHIV in Chókwè. In high HIV-prevalence settings with low testing coverage, repeated HBHTS can be considered to increase HIV testing uptake and diagnosis among NTs.
Influence of virtual reality visual feedback on the illusion of movement induced by tendon vibration of wrist in healthy participants
Authors: Le Franc Salomé , Fleury Mathis , Cogne Mélanie , Butet Simon , Barillot Christian , Lecuyer Anatole , Bonan Isabelle 
Published: November 2020

Introduction
Illusion of movement induced by tendon vibration is an effective approach for motor and sensory rehabilitation in case of neurological impairments. The aim of our study was to investigate which modality of visual feedback in Virtual Reality (VR) associated with tendon vibration of the wrist could induce the best illusion of movement.

Methods
We included 30 healthy participants in the experiment. Tendon vibration inducing illusion of movement (wrist extension, 100Hz) was applied on their wrist during 3 VR visual conditions (10 times each): a moving virtual hand corresponding to the movement that the participants could feel during the tendon vibration (Moving condition), a static virtual hand (Static condition), or no virtual hand at all (Hidden condition). After each trial, the participants had to quantify the intensity of the illusory movement on a Likert scale, the subjective degree of extension of their wrist and afterwards they answered a questionnaire.

Results
There was a significant difference between the 3 visual feedback conditions concerning the Likert scale ranking and the degree of wrist’s extension (p<0.001). The Moving condition induced a higher intensity of illusion of movement and a higher sensation of wrist’s extension than the Hidden condition (p<0.001 and p<0.001 respectively) than that of the Static condition (p<0.001 and p<0.001 respectively). The Hidden condition also induced a higher intensity of illusion of movement and a higher sensation of wrist’s extension than the Static condition (p<0.01 and p<0.01 respectively). The preferred condition to facilitate movement’s illusion was the Moving condition (63.3%).

Conclusions
This study demonstrated the importance of carefully selecting a visual feedback to improve the illusion of movement induced by tendon vibration, and the increase of illusion by adding VR visual cues congruent to the illusion of movement. Further work will consist in testing the same hypothesis with stroke patients.