bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hombres, Salud sexual y salud reproductiva
Authors: Díaz R Diana Ibeth , Guerrero Parra Nury Constanza , Robles Carreño Martha Isabel , Rodríguez Medina Janeth , Lafaurie Villamil María Mercedes 
Published: November 2020

Se realizó una lectura crítica con perspectiva de género de la investigación reciente sobre hombres, salud sexual y salud reproductiva en América Latina, basada en una revisión de la literatura. Fueron sistematizados y analizados 55 estudios. Se halló que la masculinidad hegemónica sigue presente en las vivencias sexuales y reproductivas de los varones en la región, a pesar de observase el tránsito hacia nuevas masculinidades especialmente enlazado con la vivencia de la paternidad. Desde la adolescencia se observa la construcción de valores, ideas y prácticas anudadas a la naturalización de una sexualidad masculina ajena al cuidado de sí y de otros. Los estudios sobre infecciones de transmisión sexual y VIH-sida muestran que los estereotipos viriles llevan a no percibir el riesgo de infectarse. De igual modo, impiden a los hombres consultar ante la presencia de problemas que afectan la sexualidad. Los servicios de salud sexual y reproductiva aparecen en los estudios como excluyentes de los hombres y poco preparados para atender a la población masculina en los diferentes momentos del curso de vida y en la amplitud de sus necesidades de salud, además de mostrar ser poco integrales en su abordaje y poco sensibles a la diversidad. Como los conocimientos sobre sexualidad no son suficientes para desarrollar actitudes de autocuidado y conciencia del cuidado de otros, los autores insisten en la importancia de impactar las construcciones sobre la masculinidad. Cuando están diseñados para responder a las necesidades de los hombres, con perspectiva de masculinidades, los programas logran ejercer cambios positivos.
No todos fueron rebeldes
Authors: Vega Natalia 
Published: November 2020

El presente trabajo se orienta a reconstruir el repertorio discursivo y el accionar de los grupos estudiantiles que apoyaron la reestructuración autoritaria del sistema universitario nacional argentino implementada por la dictadura de la autoproclamada “Revolución Argentina”, o que, en dicho escenario, presentaban una marcada tendencia conservadora e incluso reaccionaria frente a las luchas y movilizaciones populares. La escala de análisis elegida corresponde al ámbito de lo local, particularmente al espacio universitario de la ciudad de Santa Fe. Y en cuanto al recorte temporal, el análisis se centra en la primera etapa de la dictadura, aquella presidida por Juan Carlos Onganía -etapa conocida como Onganiato- y que constituye el núcleo del ciclo de protesta estudiantil iniciado en respuesta a la reestructuración autoritaria mencionada.
Rapid Eocene Exhumation of the West Qinling Belt: Implications for the Growth of the Northeastern Tibetan Plateau
Authors: Zhang Yi-Peng , Zheng Wen-Jun , Wang Wei-Tao , Tian Yun-Tao , Zhou Renjie , Xu Bin-Bin , Li Min-Juan , Yan Yong-Gang , Tian Qing-Ying , Zhang Pei-Zhen 
Published: November 2020

Abstract
Cenozoic exhumation in the northeastern Tibetan Plateau provides insights into spatial-temporal patterns of crustal shortening, erosion, landscape evolution, and geodynamic drivers in the broad India-Eurasia collision system. The NW-SE trending West Qinling Belt has been a central debate as to when crustal shortening took place. Within the West Qinling Belt, a thick succession of Cretaceous sedimentary rocks has been deformed and exhumed along major basin-bounding thrust faults. We present new apatite (U-Th)/He ages from the hanging wall and footwall of this major thrust. Contrasting thermal histories show that rapid cooling commenced as early as ca. 45 Ma and continued for 15–20 Myr for the hanging wall, whereas the footwall experiences continuous cooling and slow exhumation since the late Mesozoic. We infer that accelerated exhumation was driven by thrusting in response to the northward growth of the Tibetan Plateau during the Eocene (ca. 45–35 Ma) based on regional sedimentological, structural, and thermochronological data.
Cost Effective and Ecologically Sound Fluid Disposal During Well Clean up and Post Fracturing Flowback Operations
Authors: Shumakov Yakov , Hollaender Florian , Theuveny Bertrand 
Published: November 2020

AbstractAn important aspect of the well test and poststimulation flowback operations is the need to produce, responsibly manage, and safely dispose of the substantial amount of hydrocarbons, typically through flaring, which is potentially an environmental concern. This challenge has received significant attention over the past few decades and remains a major concern today. It is especially important in offshore environments, considering requirements for safe disposal of large volumes of crude and gas as well as completion fluids and possibly formation water.A common alternative to offshore flaring is storing the crude on the drilling rig, test barge, or tanker. The methods used for fluid disposal during offshore operations were reviewed as the basis for defining a practical workflow to select the optimal operations design, thus leading to a significant reduction or full elimination of burning. Inaccurately selected fluid disposal strategies can significantly constrain operations, limiting achievable objectives and increasing the risk of HSE incidents. The typical methods employed include fluid storage at the well site, high efficiency burners, and the transfer of produced liquids to oil tankers during extended well tests. Additional considerations from traditional approaches relate to the evolution of regulatory and legal frameworks on environmental concerns.Each method has its benefits and practical limitations. An analysis of possible approaches to avoid burning fluids and minimizing operational limits to well test operations identified that starting from a certain volume, crude storage and the transfer to production facilities can be considered as the best option to avoid burning while adding value to well effluents and turning well tests from a cost-to revenue-generating activity. Focusing on offshore operations with limited deck space and thus potentially limited storage capacity, the solution developed for the North Sea involved transferring the produced crude into a small shuttle tanker via a soft wall surface floating rubber hose. By using a floating transfer hose, the special requirements for hose installation were avoided, saving valuable rig time. It also reduced the need for pipe preheating and enabled the tanker to move, decreasing petrol consumption for maintaining dynamic positioning.The paper will summarize the results and lessons learned from the application of different methods used for fluid disposal in a wide range of well test operations around the globe. These were used to determine that economical and environmentally responsible solutions exist for fluid disposal during well test operations. The paper will also detail an innovative, field-proven, and cost-effective fluid storage solution using a shuttle tanker during well test and flow back operations offshore. This technique was applied in five successfully performed well tests in the North Sea, storing more than 50,000 barrels of reservoir crude in total.
A Mechanistic Gas Kick Model to Simulate Gas in A Riser with Water and Synthetic-Based Drilling Fluid
Authors: Manikonda Kaushik , Hasan Abu Rashid , Barooah Abinash , Rahmani Nazmul H. , El-Naas Muftah , Sleiti Ahmad Khalaf , Rahman Mohammad Azizur 
Published: November 2020

AbstractThis paper presents a simple mechanistic model to describe a gas kick in a drilling riser with water-based mud (WBM) and synthetic-based mud (SBM). This model can estimate key kick parameters such as the change in the wellhead pressure, kick ascent time, and pit gain. In addition, this model also predicts the solubility of the gas kick in SBM at various depths in the annulus. We used the commercial chemical process simulation software, HYSYS, to validate the results of this solubility model. This paper also presents the gas kick experimental results from a 20-ft. tall vertical flow loop at Texas A&M University, Qatar.The base case investigates a gas kick in a vertical 10,000 ft. deep, 12.415 in. drilling riser with WBM. Our analytical model uses the Hasan-Kabir two-phase flow model and develops a set of equations that describe the pressure variation in the annulus. This computed pressure change allows estimates of pit-gain. Our experimental data comes from a 20-ft. tall flow loop with a 2.5 in. steel tube, inside a 4.5 in. Acrylic pipe, that simulates a riser. For these gas kick experiments, we injected specific amounts of gas at the bottom of the setup and recorded the bubble's expansion and migration.The mechanistic model predicted explosive unloading of the riser near the wellhead. A comparison between our model results and HYSYS values for methane liquid-phase mole fraction showed a maximum 8% deviation with complete agreement on bubble point (Pb) pressure and location estimates. Similarly, our model calculated the solution gas-oil ratio (Rs), with a maximum divergence of 3% from HYSYS estimates. From the comparison studies with other empirical Bo & Rs correlations, we note that the estimates of our model agreed best with those of O'Bryan's (Patrick Leon O'Bryan, 1988) correlations.Numerical kick simulators that exist today are notoriously time and power-intensive, limiting their on-field utility. Our mechanistic model minimizes computation time through its simple, analytical form to describe kick migration. Our model offers another layer of novelty through the analytical, thermodynamic solubility modeling as opposed to empirical modeling sused by most of the current gas kick simulators.
An Integrated Approach to Quantify Reservoir Uncertainties for a Reliable Production Forecast and Faster Modelling Process for Offshore Field, Abu Dhabi, UAE
Authors: Alqallabi Salah , Abdulla Mohammed , Bahussain Esra , Al-Jenaibi Faisal , Parra Humberto , Shebl Hesham , Altaf Basit , Nehaid Hani , Fathy Amr , Al Mentheri Khawla 
Published: November 2020

AbstractThis paper presents the implementation of an integrated reservoir modeling approach that tightly connects and integrates different reservoir modeling disciplines. The approach allows the propagation of subsurface reservoir uncertainties across the various modelling domains, from seismic interpretation though to dynamic reservoir simulation and surface facilities modeling. The results achieved by this approach is a geologically consistent ensemble of runs (100 runs or more) that matches observed data and capable of predicting the future field performance under various development scenarios with a higher degree of reliability. Using an ensemble of runs that first honor the geological facies, as initially defined in the prior probability field, and subsequently updated by reservoir production behavior in the post probability field, enables the user to predict future field performance by allowing hydrocarbon recovery probabilities to be calculated, where the impact of subsurface reservoir uncertainties on prediction results and the possible risk in each development decision is estimated.The field studied is located Offshore in Abu Dhabi and has four main, two secondary, and few minor stacked carbonate reservoirs. Available evidence indicates that the field's reservoirs are not in communication and this study focuses on the main and secondary units. The conceptual geological model proposes that all the zones are conformable, with no truncation or pinching, forming a layer cake depositional model in which reservoirs range in thickness, from few feet in thin zones, to tens of feet in thick zones. Over time the field has been affected by different tectonic stress regimes, resulting in complex strike slip faulting, extending vertically across all reservoirs.Quantification of static and dynamic uncertainties together in the applied methodology is improving the team integration and common understanding for the field structural and geomodelling uncertainties and its impact on the dynamic model behavior for different reservoirs. The methodology has been tested where new drilled well data is included at different times and it showed an easy and quick update for the entire workflow from seismic to simulation. The model was calibrated to historical observed data using different geological uncertainties (structural, facies, geomodelling and dynamic uncertainties) which helped to achieve a geologically consistent and reliable models.
A Comprehensive Model for Acid Stimulation of Lower Completions
Authors: Mogensen Kristian , Edmonstone Graham 
Published: November 2020

AbstractLong horizontal or highly deviated wells require lower completion liners to improve well and reservoir management of the carbonate reservoirs in ADNOC's portfolio. Optimum well productivity depends on effective stimulation post drilling. Traditionally, a complicating factor in a matrix-acid stimulation treatment has been poor control of the acid placement along the reservoir section to total depth (TD) without stage equipment or chemical diverters. The limited-entry liner (LEL) lower completion addresses the shortcomings of other stimulation techniques. It consists of a number of unevenly spaced holes with the purpose to distribute acid evenly along the reservoir section to be stimulated. ADNOC is planning to execute a series of pilots to test and possibly expand the operational envelope of the LEL technique.Design of a the hole-size distribution requires a mathematical model, which accounts for the various pressure drops encountered in the system as well as the impact of the chemical reaction between acid and rock. In this work, we present a comprehensive algorithm for designing a hole-size distribution which yields a user-specified acid coverage and also provides the best possible wormhole penetration, subject to a number of constraints related to surface pressure, pump rate, and acid volume available. We make use of findings published over the past 15 years in the SPE literature to arrive at an enhanced design philosophy, which is appropriate for the carbonate reservoirs in ADNOC's portfolio.The design model takes into account a number of important parameters, including fluid and reservoir properties, as well as completion information such as tubing ID, liner ID, and the LEL hole sizes. A check is made using nodal analysis software to ensure that the LEL completion does not act as a flow restriction during back-production.
Are normoglycaemic individuals at risk of depression? The depression-dysglycaemic phenotype from a European population-based cross-sectional study
Authors: Cuschieri Sarah , Mamo Julian 
Published: November 2020

Abstract
Background Depression is a chronic non communicable disease. It is a growing public health concern with established links with a number of co-morbidities, including diabetes mellitus. The study aimed to estimate the prevalence of depression at a population level, establish the depression sub-population phenotypic characteristics while exploring for links between depression and a spectrum of glycemic abnormalities. Methods A nationally representative cross-sectional study was conducted in Malta between 2014 and 2016. Participants were categorized into different sub-populations according to their glycaemic status. Depression prevalence rates and phenotypic characteristics for each sub-population were established. Multiple regression analysis was performed to identify links with depression. Results Depression was prevalent in 17.15% (CI 95%: 16.01 – 18.36) with a female predominance. Those with known (as opposed to newly diagnosed) diabetes had the highest depression prevalence when compared to other glycemic sub-groups. These also exhibited a significant link with self-reported depression. However, at a population level, depression was mostly prevalent within the normoglycaemic sub-population. Conclusions The study confirms the strong link between diabetes and depression, especially, in a high risk dysglycaemic population. Of public health concern is the high depression occurrence within the normoglycaemic sub-population, which attributed for the majority of the Maltese population. In order to reduce the impact of mental health on the population, physicians may consider implementing depression screening clinical tools as part of their routine health check-ups at primary care level, irrespective of the glycaemic status of their patients.
Extraction of nuclei from archived post-mortem tissues for single-nucleus sequencing applications
Authors: Maitra Malosree , Nagy Corina , Wang Yu Chang , Nascimento Camila , Suderman Matthew , Théroux Jean-Francois , Mechawar Naguib , Ragoussis Jiannis , Turecki Gustavo 
Published: November 2020

Abstract
Single-cell and single-nucleus sequencing techniques are a burgeoning field with various biological, biomedical, and clinical applications. Numerous high and low-throughput methods have been developed for sequencing the RNA and DNA content of single cells. However, for all these methods the key requirement is high quality input of a single-cell or single-nucleus suspension. Preparing such a suspension is the limiting step when working with fragile, archived tissues of variable quality. This hurdle can prevent such tissues from being extensively investigated with single-cell technologies. We describe a protocol for preparing single-nucleus suspensions within the span of a few hours that reliably works for multiple post-mortem and archived tissues types using standard lab equipment. Moreover, these preparations are compatible with single-nucleus RNA-seq and ATAC-seq using the 10X Genomics’ Chromium system.
Specific immune modulation of experimental colitis drives enteric alpha-synuclein accumulation and triggers age-related Parkinson-like brain pathology
Authors: Grathwohl Stefan , Quansah Emmanuel , Maroof Nazia , Steiner Jennifer A , Spycher Liz , Benmansour Fethallah , Duran-Pacheco Gonzalo , Siebourg-Polster Juliane , Oroszlan-Szovik Krisztina , Remy Helga , Haenggi Markus , Stawiski Marc , Selhausen Matthias , Maliver Pierre , Wolfert Andreas , Emrich Thomas , Madaj Zachary , Su Arel , Galvis Martha L Escobar , Mueller Christoph , Herrmann Annika , Brundin Patrik , Britschgi Markus 
Published: November 2020

Abstract
Background : Intraneuronal accumulation of a-synuclein (αSyn) is key in Parkinson’s disease (PD) pathogenesis. The pathogenic process is suggested to begin in the enteric nervous system decades before diagnosis of PD and then propagate into the brain. The triggers for these events are unclear but, in some patients, colitis might play a critical role. Methods : We administered lipopolysaccharide (LPS) or dextran sulfate sodium (DSS) to assess the effect of different types of experimental colitis on αSyn accumulation in the gut of αSyn transgenic and wild type mice and quantified local gene expression by RT-PCR and level of αSyn accumulation by immunofluorescence imaging. Immune modulation during the DSS colitis paradigm in the αSyn transgenic mice included genetic ablation of Cx3cr1 or treatment with recombinant IL-10. To determine long-term effects of experimental colitis, we induced DSS colitis in young αSyn transgenic mice and aged them under normal conditions up to nine or 21 months before analyzing their brains by immunohistochemistry. In vivo experiments were performed in randomized cohorts. Blinded experimenters performed image analysis and statistical analysis depended on data type (i.e., Student’s t-test, ANOVA, mixed-effects model). Results : We demonstrate that mild sustained or one strong insult of experimental DSS colitis triggers αSyn accumulation in the submucosal plexus of wild type and αSyn transgenic mice, while short-term mild DSS experimental colitis or inflammation induced by LPS does not have such an effect. Lack of macrophage-related Cx3cr1-signalling during DSS colitis increases accumulation of αSyn in the colonic submucosal plexus of αSyn transgenic mice while systemic treatment with immune-dampening IL-10 ameliorates this phenomenon. Additionally, DSS colitis-induced αSyn accumulation in young αSyn transgenic mice persists for months and is exacerbated by lack of Cx3cr1-signaling. Remarkably, experimental colitis at three months of age exacerbates the accumulation of aggregated phospho-Serine 129 αSyn in the midbrain (including the substantia nigra), in 21- but not 9-month-old αSyn transgenic mice. This increase in midbrain αSyn accumulation is accompanied by the loss of tyrosine hydroxylase-immunoreactive nigral neurons. Conclusions : Our data suggest that specific types of intestinal inflammation, mediated by monocyte/macrophage signaling, could play a critical role in the initiation and progression of PD.
Assessment on knowledge, attitude, practices and risk of infection towards COVID-19 in Ethiopia: An online cross-sectional survey
Authors: Benor Solomon , Abera Solomon , Mandefro Ayele , Konwarh Rocktotpal , Suresh Arumuganainar 
Published: November 2020

Abstract
COVID-19 has ushered in a catastrophe of an unprecedented scale across all parts of the world. Confirmed cases and death toll are constantly on an upward trend. Various measures to control the disease have been adopted globally including in Ethiopia. However, people’s adherence to such control measures is affected by their knowledge, attitudes and practices (KAP) during the pandemic. This cross-sectional online survey was therefore, conducted to appraise the KAP vis-a-vis COVID-19 containment strategy during May 13-25, 2020. The online survey questionnaire consisted of demographic characteristics and interrogations, pertaining to knowledge (15 items), attitude (10 items) and practices (7 items), framed in accordance to previous studies. A total of 1,484 respondents completed the survey. The overall correct response rating and average score of the knowledge were 74.7 % and 11.2 ± 2.2 respectively. Maximum respondents (63 %) could be bracketed together with a moderate level on knowledge, attitudes while only 43 % had moderate level of practice, with significant difference across demographic variables. Despite the moderate level, the practices were not creditable as the registered values evinced that 1 out of 5 never wore nose mask, washed hands or maintained social distance. In a similar vein, 17.6 %, and 43.2 % of the respondents were in high and in medium risk of infection, respectively. Results of our study recommended the importance and need of health education programs aimed at improving KAP, especially the practices in the milieu of COVID-19.
Recurrent recurrence of positive SARS-CoV-2 RNA in a COVID-19 patient
Authors: Cao Shugang , Wu Aimei , Li Jiaxia , Li Yuancheng , Xia Mingwu , Wu Juncang 
Published: November 2020

Abstract
Background: Coronavirus disease 2019 (COVID-19) is a highly infectious disease. A small proportion of discharged patients became positive again for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA, even though they met the discharge criteria. Herein, we report a rare COVID-19 patient with recurrent recurrence of positive SARS-CoV-2 RNA.Case presentation: A 68-year-old man was admitted due to fever, muscle pain, and fatigue. He was initially diagnosed with COVID-19 according to two consecutive positive results for SARS-CoV-2 RNA. He was discharged from hospital when meeting the discharge criteria. He tested positive for SARS-CoV-2 RNA twice during the quarantine and was hospitalized again. He was asymptomatic then, but IgG and IgM anti-SARS-CoV-2 were both positive. He was discharged in the context of four consecutive negative test results for SARS-CoV-2 RNA after antiviral treatment. However, he tested positive once again on the 3rd and 4th days after the second discharge. Two days later, the SARS-CoV-2 RNA results became negative in three consecutive retests, and he was finally discharged. Conclusion: This case suggests that convalescent patients may become positive again for SARS-CoV-2 RNA after discharge due to prolonged nucleic acid transition. However, the potential infectivity of these patients needs to be further confirmed in future research.