bluuebunny/crossref_metadata_2025_split huggingface dataset:
[Fe(III)(MeO‐salen)Cl] complexes and their in vitro cytotoxicity against KB and HepG2 human cancer cells
Authors: Trung Nguyen Quang , Phuong Nam Pham Thi , Phuong Chi Nguyen Thi , Van Tuyen Nguyen 
Published: February 2020

AbstractMethoxy‐substituted iron(III)‐salen complexes ([Fe(III)(MeO‐salen)Cl] with salen = N,N’‐bis(salicylidene)‐1,2‐ethylenediimine) were synthesized and structurally analyzed. Their in vitro cytotoxicity against KB and HepG2 human cancer cells was examined. The obtained results obviously demonstrated the correlation between the cytotoxicity of the complexes and the position of methoxy substituents in the salicylidene moieties as the following; 3‐OCH3 < H ~ 6‐OCH3 < 4‐OCH3 < 5‐OCH3.
Extraction of hydroxyapatite and collagen from the Vietnamese tilapia scales
Authors: Chinh Nguyen Thuy , Manh Vu Quoc , Trung Vu Quoc , Trang Tran Do Mai , Hoang Thai 
Published: February 2020

AbstractThis study reports the suitable condition to extract hydroxyapatite (HAp) and collagen from tilapia scales in North Viet Nam. The tilapia scales were treated by Ca(OH)2 5 % solution for 24 hours to remove protein, fat and impurities. The protein‐free scales were continuously sunk in mixture acid solutions to remove minerals. The HAp was obtained from this solution by precipitating with 0.5 M NaOH. The mineral‐free scales were immersed in 0.5 M CH3COOH solution and precipitated collagen was obtained by adding of 0.5 M NaCl solution. The methods including Energy dispersive X‐ray diffraction (EDX), Fourier transform infrared spectroscopy (FTIR), Field emission scanning electron microscopy (FESEM) were used to determine characteristics, structure and morphology of HAp and collagen. The HAp was dried at 150°C for removing water and some organic substances and then, washed repeatedly by distilled water to obtain high purity HAp, size of 30‐40 nm, and Ca/P ratio = 1.70, closed to Ca/P ratio = 1.67 in bones and human teeth. The collagen was obtained in raw form, contains C, N, O, S, Na, Cl atoms in structure.
Anti‐inflammatory phenylpropanoid glycosides from the roots of Polygala aureocauda Dunn
Authors: Quang Tran Hong , Yen Duong Thi Hai , Dung Duong Thi , Trang Do Thi , Ngan Nguyen Thi Thanh , Van Kiem Phan , Van Minh Chau 
Published: February 2020

AbstractChemical study on a methanol extract of the roots of Polygala aureocauda Dunn. resulted in the isolation of three phenylpropanoid glycosides, including β‐D‐[3‐O‐(3,4,5‐trimethoxycinnamoyl)]‐fructofuranosyl‐α‐D‐[6‐O‐(4‐methoxybenzoyl)]‐glucopyranoside (1), β‐D‐(3‐O‐sinapoyl)‐fructofuranosyl‐α‐D‐(6‐O‐sinapoyl)‐glucopyranoside (2), and tenuifoliside C (3). Their chemical structures were elucidated by NMR and MS spectroscopic analysis in comparison with the data reported in the literature. Of the isolates, compound 1 inhibited NO and PGE2 overproduction in LPS‐stimulated RAW264.7 macrophages, with IC50 value of 29.7 and 28.7 μM. These effects of 1 were shown to be related to its suppressive effects on iNOS and COX‐2 protein expression.
Direct synthesis of CeO2 nanospindles on gold electrode by electrochemical method
Authors: Nguyet Nguyen Thi , Trung Tran , Lan Hoang , Van Thu Vu , Vuong Pham Hung , Tam Phuong Dinh 
Published: February 2020

AbstractIn the present study, we reported direct synthesis of CeO2 nanospindle on gold electrode by using cyclic voltammetry (C‐V) method. The method advantages are simple, low cost, room temperature, without using any templates. The synthesized nanospindles were characterized by Field Emission Scanning Electron Microscopy (FE– SEM), Energy Dispersive X‐ray Spectroscopy (EDS) and X‐ray diffraction (XRD). The propery characterization of the samples was studied by electrochemical impedance spectroscopy (EIS) and Photoluminescence spectroscopy (PL). It was found that these nanospindles are approximately 700 nm and diameter of about 100‐200 nm. Optimal parameters such as scan rate, scan cycle, and Ce3+ concentration were also investigated.
Effect of (3‐aminopropyl)triethoxysilane coupling agent on characteristics and mechanical properties of polylactic acid/jute fiber biocomposite
Authors: Huynh Mai Duc , Trung Tran Huu , Thai Nguyen Thi , Van Cong Do , Tung Nguyen Huy , Giang Nguyen Vu 
Published: February 2020

AbstractBiocomposites based on polylactic acid (PLA) and jute fiber (JF) (90/10 wt.%/wt.%) were prepared by melt mixing method in the internal Poly Haake mixer. Before preparing PLA/JF biocomposites, JF was cut into the shorter fiber with 1‐2 mm in length and was modified by 1, 5 and 10 wt.% of (3‐aminopropyl)triethoxysilane (APTES). Fourier transform infrared (FTIR) spectroscopy was conducted to evaluate the presence of APTES on the JF surface. The mechanical properties of PLA/JF biocomposites including tensile strength, Young's modulus and impact strength were investigated. It is found that APTES improved remarkably the mechanical properties and reached the maximum values for sample using 5 wt.% APTES. The composites using modified JF showed the higher thermal stability in comparison to the unmodified sample. SEM micrographs of the fractured surface area exhibited the better adhesion between JF and PLA matrix after modification.
Relationship between wheat root properties and its electrical signature using the spectral induced polarization method
Authors: Tsukanov Kuzma , Schwartz Nimrod 
Published: February 2020

AbstractMeasuring root properties, the “hidden half” of the plant, is challenging due to their heterogeneous and dynamic nature. A promising method for noninvasive mapping of roots and their activity, spectral induced polarization (SIP), has been introduced. However, measurements of root properties together with their SIP responses are missing, limiting the interpretation of a root's SIP signature. In this study, we coupled SIP measurements of roots in hydroponic solution with measurements of root biomass, surface area, and diameter. Furthermore, we monitored the SIP response of roots poisoned by cyanide, which results in depolarization of the root's cell membrane potential. We found a linear correlation between root biomass and surface area, and the low‐frequency electrical polarization. In addition, we demonstrate the relationship between root cell membrane potential and root polarization. Based on the results, we suggest that in comparison with the stem‐based approach used by other researchers, the polarization in the contact‐free method used in this study is related to the external surface area of the root and external architectural structures such as root diameter and root hair. Overall, a direct link between root properties and their electrical signature was established.
On shape dependence of holographic entanglement entropy in AdS4/CFT3 with Lifshitz scaling and hyperscaling violation
Authors: Cavini Giacomo , Seminara Domenico , Sisti Jacopo , Tonni Erik 
Published: February 2020

Abstract
We study the divergent terms and the finite term in the expansion of the holographic entanglement entropy as the ultraviolet cutoff vanishes for smooth spatial regions having arbitrary shape, when the gravitational background is a four dimensional asymptotically Lifshitz spacetime with hyperscaling violation, in a certain range of the hyperscaling parameter. Both static and time dependent backgrounds are considered. For the coefficients of the divergent terms and for the finite term, analytic expressions valid for any smooth entangling curve are obtained. The analytic results for the finite terms are checked through a numerical analysis focussed on disks and ellipses.
Polychlorinated Biphenyls (PCBs) and Sex Hormone Concentrations in Ringed and Grey Seals: A Possible Link to Endocrine Disruption?
Authors: Troisi G. M. , Barton S. J. , Liori O. , Nyman M. 
Published: February 2020

AbstractPolychlorinated biphenyls (PCBs) are recognised reproductive and immune system toxicants in marine mammals mediated by endocrine-disrupting mechanisms. As with other predators, seals are exposed to elevated bioaccumulated concentrations of PCBs and other persistent organic pollutants (POPs). Cryopreserved plasma samples from adult ringed (Phoca hispida; n = 39) and grey (Halichoerus grypus; n = 38) seals, sampled between 1998 and 2002 from Baltic Sea, Svalbard, and Sable Island (Canada) were used to investigate relationships between PCB exposure and sex hormone concentrations (progesterone; P4, 17α-hydroxy progesterone; 17α-OH-P4, testosterone; T4, 17β-estradiol; E2, estrone; E3). Immunoassay methods were used for quantification of analytes due to the limited sample volumes available. PCB concentrations were found to be significantly higher in Baltic seals than other sampling locations and were classed as “Exposed” seals while Svalbard and Sable Is seal were classed “Reference” seals (sexes and species separate). Mean hormone concentrations in Exposed seal were lower than Reference seals, and this was statistically significantly for 17α-OH-P4 (both sexes and both species), E2 (ringed and grey seal females), and E3 (grey seal females). Regression analyses (PCB v hormone concentrations) for each sex and species revealed significant correlations for P4 (Sable Is. female grey seals and female ringed seals), 17α-OH-P4 (Sable Is. male grey seals and Svalbard male ringed seals), T4 (Svalbard male ringed seals), E2 (female ringed seals), and E3 (female ringed seals and Baltic female grey seals). Although significant correlations are not evidence of cause and effect, the potential impact of hormone changes on endocrine homeostasis and reproductive health for seal populations warrants further investigation given that PCB concentrations found here are in the same range as those currently reported in seals from these populations.
Impact on clinical practice of updated guidelines on iodinated contrast material: CINART
Authors: Nijssen E. C. , Nelemans P. J. , Rennenberg R. J. , van der Molen A. J. , van Ommen G. V. , Wildberger J. E. 
Published: February 2020

Abstract
Objective
Guidelines on safe use of iodinated contrast material recommend intravenous prophylactic hydration to prevent post-contrast adverse (renal) effects. Recently, guidelines have been updated and standard prophylaxis is no longer recommended for the majority of patients. The current study aims to evaluate the consequences for clinical practice of the updated guidelines in terms of complications, hospitalisations, and costs.

Methods
The Contrast-Induced Nephropathy After Reduction of the prophylaxis Threshold (CINART) project is a retrospective observational study. All elective procedures with intravascular iodinated contrast administration at Maastricht University Medical Centre (UMC+) in patients aged > 18 years, formerly eligible for prophylaxis (eGFR 30–44 ml/min/1.73 m2 or eGFR 45–59 ml/min/1.73 m2 in combination with diabetes or > 1 predefined risk factor), and currently eligible for prophylaxis (eGFR < 30 ml/min/1.73 m2) were included. Data were used to calculate relative reductions in complications, hospitalisations, and costs associated with standard prophylactic intravenous hydration. CINART is registered with Clinicaltrials.gov: NCT03227835.

Results
Between July 1, 2017, and July 1, 2018, 1992 elective procedures with intravascular iodinated contrast in patients formerly and currently eligible for prophylaxis were identified: 1808 in patients formerly eligible for prophylaxis and 184 in patients currently eligible for prophylaxis. At Maastricht UMC+, guideline updates led to large relative reductions in numbers of complications of prophylaxis (e.g. symptomatic heart failure; − 89%), extra hospitalisations (− 93%), and costs (− 91%).

Conclusion
Guideline updates have had a demonstrable impact on daily clinical practice benefiting patient, hospital, and health care budgets. Clinical practice varies between institutions and countries; therefore, a local estimation model is provided with which local impact on costs, hospitalisations, and complications can be calculated.

Key Points
• Clinical practice guidelines recommend prophylactic intravenous hydration to prevent post-contrast adverse outcomes such as contrast-induced acute kidney injury.
• Clinical practice guidelines have recently been updated, and standard prophylaxis is no longer recommended for the majority of patients.
• The guideline updates have a large impact on daily clinical practice: relative reductions at Maastricht UMC+ were − 89% prophylaxis complications, − 93% hospitalisations, and − 91% costs, and similar reductions are expected for Dutch and adherent European medical centres.
Local osteo-enhancement of osteoporotic vertebra with a triphasic bone implant material increases strength—a biomechanical study
Authors: Trost Matthias , Schmoelz Werner , Wimmer Doris , Hörmann Romed , Frey Sönke , Schulte Tobias Ludger 
Published: February 2020

Abstract
Purpose
The aim of this study was to assess the biomechanical properties of intact vertebra augmented using a local osteo-enhancement procedure to inject a triphasic calcium sulfate/calcium phosphate implant material.

Methods
Twenty-one fresh frozen human cadaver vertebra (Th11–L2) were randomized into three groups: treatment, sham, and control (n = 7 each). Treatment included vertebral body access, saline lavage to displace soft tissue and marrow elements, and injection of the implant material to fill approximately 20% of the vertebral body by volume. The sham group included all treatment steps, but without injection of the implant material. The control group consisted of untreated intact osteoporotic vertebra. Load at failure and displacement at failure for each of the three groups were measured in axial compression loading.

Results
The mean failure load of treated vertebra (4118 N) was significantly higher than either control (2841 N) or sham (2186 N) vertebra (p < 0.05 for: treatment vs. control, treatment vs. sham). Treated vertebra (1.11 mm) showed a significantly higher mean displacement at failure than sham vertebra (0.80 mm) (p < 0.05 for: treatment vs. sham). In the control group, the mean displacement at failure was 0.99 mm.

Conclusions
This biomechanical study shows that a local osteo-enhancement procedure using a triphasic implant material significantly increases the load at failure and displacement at failure in cadaveric osteoporotic vertebra.
Euploid miscarriage is associated with elevated serum C-reactive protein levels in infertile women: a pilot study
Authors: Weghofer Andrea , Barad David H. , Darmon Sarah K. , Kushnir Vitaly A. , Albertini David F. , Gleicher Norbert 
Published: February 2020

Abstract
Purpose
Increased serum C-protein (CRP) levels reduce fecundity in healthy eumenorrheic women with 1–2 pregnancy losses. Subclinical systemic inflammation may impede maternal immune tolerance toward the fetal semi-allograft, compromising implantation and early embryonic development. Some miscarriages with normal karyotypes could, therefore, be caused by inflammation. Whether pre-pregnancy CRP relates to karyotypes of spontaneously aborted products of conception (POCs) was investigated.

Methods
A study cohort of 100 infertile women with missed abortions who underwent vacuum aspirations followed by cytogenetic analysis of their products of conception tissue was evaluated at an academically affiliated fertility center. Since a normal female fetus cannot be differentiated from maternal cell contamination (MCC) in conventional chromosomal analyses, POC testing was performed by chromosomal microarray analysis. MCC cases and incomplete data were excluded. Associations of elevated CRP with first trimester pregnancy loss in the presence of a normal fetal karyotype were investigated.

Results
Mean patients’ age was 39.9 ± 5.8 years; they demonstrated a BMI of 23.9 ± 4.6 kg/m2 and antiMullerian hormone (AMH) of 1.7 ± 2.4 ng/mL; 21.3% were parous, 19.1% reported no prior pregnancy losses, 36.2% 1–2 and 6.4% ≥ 3 losses. Karyotypes were normal in 34% and abnormal in 66%. Adjusted for BMI, women with elevated CRP were more likely to experience euploid pregnancy loss (p = 0.03). This relationship persisted when controlled for female age and AMH.

Conclusions
Women with elevated CRP levels were more likely to experience first trimester miscarriage with normal fetal karyotype. This relationship suggests an association between subclinical inflammation and miscarriage.
The impact of a standardized vocal loading test on vocal fold oscillations
Authors: Echternach Matthias , Huseynov Jamal , Döllinger Michael , Nusseck Manfred , Richter Bernhard 
Published: February 2020

Abstract
Introduction
Vocal loading capacity is an important aspect of vocal health and is measured using standardized vocal loading tests. However, it remains unclear how vocal fold oscillation patterns are influenced by a standardized vocal loading task.

Methods
21 (10 male, 11 female) vocally healthy subjects were analyzed concerning the dysphonia severity index (DSI) and high speed videolaryngoscopy (HSV) on the vowel /i/ at a comfortable pitch and loudness before and after a standardized vocal loading test (10 min standardized text reading, at a level higher than 80 dB (A) measured at 30 cm from the mouth).

Results
Changes in DSI were statistically significant, diminishing by 1.2 points after the vocal loading test, which was mainly caused by an increase of the minimum intensity. However, the pre-post comparison of HSV derived measures failed to show any statistically significant changes.

Conclusion
It seems necessary to analyze the effects of a standardized vocal loading test on vocal fold oscillation patterns with respect to softest phonation and phonation threshold pressure rather than comfortable pitch and loudness.
Level of evidence
2c
Applicability of scoring systems predicting outcome of transarterial chemoembolization for hepatocellular carcinoma
Authors: Vogeler Marie , Mohr Isabelle , Pfeiffenberger Jan , Sprengel Simon David , Klauss Miriam , Teufel Andreas , Chang De-Hua , Springfeld Christoph , Longerich Thomas , Merle Uta , Mehrabi Arianeb , Weiss Karl Heinz , Mieth Markus 
Published: February 2020

Abstract
Purpose
Several scoring systems have been proposed to predict the outcome of transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). However, the application of these scores to a bridging to transplant setting is poorly validated. Evaluation of the applicability of prognostic scores for patients undergoing TACE in palliative intention vs. bridging therapy to liver transplantation (LT) is necessary.

Methods
Between 2008 and 2017, 148 patients with HCC received 492 completed TACE procedures (158 for bridging to transplant; 334 TACE procedures in palliative treatment intention at our center and were analyzed retrospectively. Scores (ART, CLIP, ALBI, APRI, SNACOR, HAP, STATE score, Child–Pugh, MELD, Okuda and BCLC) were calculated and evaluated for prediction of overall survival. ROC analysis was performed to assess prediction of 3-year survival and treatment discontinuation.

Results
In patients receiving TACE in palliative intention most scores predicted OS in univariate analysis but only mSNACOR score (p = 0.006), State score (p < 0.001) and Child–Pugh score (p < 0.001) revealed statistical significance in the multivariate analysis. In the bridging to LT cohort only the BCLC score revealed statistical significance (p = 0.002).

Conclusions
Clinical usability of suggested scoring systems for TACE might be limited depending on the individual patient cohorts and the indication. Especially in patients receiving TACE as bridging to LT none of the scores showed sufficiently applicability. In our study Child–Pugh score, STATE score and mSNACOR score showed the best performance assessing OS in patients with TACE as palliative therapy.
Class II:2 malocclusion—prevalence and progression of labial gingival recessions during Herbst-Multibracket appliance treatment
Authors: Bock N. C. , Killat S. , Ruf S. 
Published: February 2020

Abstract
Objectives
To determine the prevalence, incidence, and changes in magnitude of labial gingival recessions (LGR) in class II:2 patients during Herbst-Multibracket appliance (Herbst-MBA) treatment (Tx) plus retention.

Subjects and methods
All class II:2 patients of the Department of Orthodontics, University of Giessen, Germany who completed Herbst-MBA Tx (mean pre-Tx age 15.6 years). The cohort had undergone a Herbst phase (mean 8.1 months) as well as a subsequent MBA phase (mean 14.4 months). Study casts were evaluated from pre-Tx and after Herbst-MBA Tx plus ≥ 24 months of retention.

Results
Ratable pre-Tx and post-retention study casts (total observation period 53.5 ± 10.3 months) were available from 94 out of 173 patients. No significant difference existed regarding pre-Tx LGR data between patients with and without complete records. The prevalence for teeth with LGR ≥ 0.5 mm was 1.4% pre-Tx respectively 6.7% post-retention. The highest values of up to 5.3% (pre-Tx) and 20.2% (post-retention) were determined for the upper first premolars and lower central incisors. Incidence values of 4.7% (all teeth) and up to 14.9% (upper first right premolars) respectively 11.1% (lower central incisors) were calculated (LGR ≥ 0.5 mm). The overall LGR mean magnitudes were 0.01 mm pre-Tx respectively 0.06 mm post-retention.

Conclusions
For the prevalence of LGR ≥ 0.5 mm an average increase of 5.3% was determined during ≈ 4.5 years of Herbst-MBA Tx plus retention. The highest incidence was seen for lower central incisors and upper right premolars (11.1/14.9%). The overall LGR mean magnitude increased by 0.05 mm.

Clinical relevance
Herbst-MBA Tx is a common approach for class II:2 malocclusions. Very little, however, is known regarding LGR development in respective patients.
Life expectancy at birth in Duchenne muscular dystrophy: a systematic review and meta-analysis
Authors: Landfeldt Erik , Thompson Rachel , Sejersen Thomas , McMillan Hugh J. , Kirschner Janbernd , Lochmüller Hanns 
Published: February 2020

AbstractSeveral studies indicate that prognosis for survival in Duchenne muscular dystrophy (DMD) has improved in recent decades. However, published evidence is inconclusive and some estimates may be obsolete due to improvements in standards of care, in particular the routine use of mechanical ventilatory support in advanced stages of the disease. In this systematic review and meta-analysis (PROSPERO identifier: CRD42019121800), we searched MEDLINE (through PubMed), CINAHL, Embase, PsycINFO, and Web of Science for studies published from inception up until December 31, 2018, reporting results of life expectancy in DMD. We pooled median survival estimates from individual studies using the median of medians, and weighted median of medians, methods. Risk of bias was established with the Newcastle–Ottawa Scale. Results were stratified by ventilatory support and risk of bias. We identified 15 publications involving 2662 patients from 12 countries from all inhabited continents except Africa. Median life expectancy without ventilatory support ranged between 14.4 and 27.0 years (pooled median: 19.0 years, 95% CI 18.0–20.9; weighted pooled median: 19.4 years, 18.2–20.1). Median life expectancy with ventilatory support, introduced in most settings in the 1990s, ranged between 21.0 and 39.6 years (pooled median: 29.9 years, 26.5–30.8; weighted pooled median: 31.8 years, 29.3–36.2). Risk of bias had little impact on pooled results. In conclusion, median life expectancy at birth in DMD seems to have improved considerably during the last decades. With current standards of care, many patients with DMD can now expect to live into their fourth decade of life.