bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS KUALITAS BUTIR SOAL PADA KOMPETISI MATEMATIKA MENGGUNAKAN TEORI RESPON ITEM
Authors: Nur Andi Saparuddin , Suryani Dessy Rizki , Mayasari Dian 
Published: February 2025

Kualitas butir soal pada kompetisi matematika merupakan faktor yang wajib terpenuhi agar mampu menyeleksi peserta dengan kemampuan terbaik. Adakalanya peserta yang lolos pada babak penyisihan memanfaatkan kelemahan butir soal. Namun demikian, pendekatan klasik tidak mampu menganalisis kelemahan butir soal sehingga diperlukan pendekatan teori respon item untuk memperoleh gambaran kemampuan peserta. Penelitian ini bertujuan menganalisis kualitas butir soal yang digunakan pada babak penyisihan competition of mathematics (Comath) Universitas Musamus tahun 2023 menggunakan teori respon item. Terdapat 25 butir soal pilihan ganda dengan jumlah peserta sebanyak 24 tim. Teknik analisis menggunakan pendekatan respon item model rasch dengan bantuan software Ministep. Hasil penelitian menunjukkan skor reliabilitas butir item dan peserta pada kategori baik dengan koefisien alpha cronbach sebesar 0,91. Rata-rata kemampuan peserta berada di bawah item dengan -0,35 logit. Nilai Outfit MNSQ dan Outfit ZSTD berada pada kategori fit yang berarti bahwa seluruh item mampu mendeksripsikan kemampuan peserta secara rasional. Instrumen soal yang digunakan fit (cocok) dengan Model Rasch dalam menyeleksi kemampuan peserta dengan baik.
Strategi Kebertahanan Grup Orkes Keroncong Pentatonik Di Kabupaten Pamekasan
Authors: Bagus Pratama Ananda 
Published: February 2025

Penelitian ini bertujuan untuk mengkaji strategi kebertahanan Grup Orkes Keroncong Pentatonik di Kabupaten Pamekasan. Fokus penelitian ini adalah untuk mendeskripsikan tentang aransemen yang mendukung keberadaan grup ini serta strategi yang digunakan dalam menunjang strategi kebertahanannya. Metode penelitian yang digunakan adalah kualitatif dengan pendekatan deskriptif.
Hasil penelitian menunjukkan bahwa strategi kebertahanan Grup Orkes Keroncong Pentatonik didukung oleh kemasan aransemen lagu yang kreatif dan pemilihan repertoar yang relevan dengan selera masyarakat Pamekasan. Grup ini membawakan berbagai jenis lagu, mulai dari keroncong asli hingga lagu pop dan dangdut yang diaransemen dalam gaya keroncong. Mereka juga mempunyai strategi pemasaran seperti memanfaatkan media sosial untuk mempromosikan penampilan dan kegiatan mereka, Kesimpulannya, keberhasilan Grup Orkes Keroncong Pentatonik dalam mempertahankan eksistensinya di Kabupaten Pamekasan tidak hanya karena kualitas musikalitas mereka, tetapi juga karena strategi pemasaran yang adaptif dan inovatif.
O NEGACIONISMO CLIMÁTICO NO BRASIL
Authors: Busnardo Juliano Momenti , Mendonça Marina Célia 
Published: February 2025

Esta pesquisa pretende analisar uma entrevista de Ricardo Felício, no Programa do Jô, do ano de 2012. Nesta entrevista, o professor da USP fala sobre “a farsa do aquecimento global” e comenta sobre o tema, suscitando o discurso do negacionismo climático. Tendo essa entrevista como corpus, o objetivo do artigo é entender como o discurso de Ricardo Felício se constitui na relação com o discurso científico sobre mudanças climáticas e o aquecimento global e responder às seguintes questões: 1. Como o discurso sobre o aquecimento global na esfera científica se constitui em relação a outras esferas discursivas?; 2. Qual a importância da entonação e da avaliação no discurso de Ricardo Felício na relação com seu outro?; 3. Como o discurso de Ricardo Felício manifesta seu aspecto pseudocientífico? Para compreender este tema, esta pesquisa parte da Análise Dialógica do Discurso, baseando-se em Bakhtin, Volóchinov e seus comentadores no Brasil. Conclui-se que o discurso de Ricardo Felício pode ser entendido como pseudocientífico, no entanto, para compreender o discurso do negacionismo climático, é necessário ir além da esfera científica, entendendo que esse discurso constitui uma “controvérsia científica fabricada”, fundamentando-se e ganhando popularidade pelos elementos extracientíficos, ou seja, de outras esferas, como a política, econômica, jornalística.
COVID-19 vaccine effectiveness in the paediatric population aged 5–17 years: a multicentre cohort study using electronic health registries in six European countries, 2021 to 2022
Authors: Soares Patrícia , Machado Ausenda , Nicolay Nathalie , Monge Susana , Sacco Chiara , Hansen Christian Holm , Meijerink Hinta , Martínez-Baz Iván , Schmitz Susanne , Humphreys James , Fabiani Massimo , Echeverria Aitziber , AlKerwi Ala’a , Nardone Anthony , Mateo-Urdiales Alberto , Castilla Jesús , Kissling Esther , Nunes Baltazar ,   VEBIS-Lot 4 working group
Published: February 2025

Background
During the first year of the COVID-19 pandemic, vaccination programmes targeted children and adolescents to prevent severe outcomes of SARS-CoV-2 infection.

Aim
To estimate COVID-19 vaccine effectiveness (VE) against hospitalisation due to COVID-19 in the paediatric population, among those with and without previously documented SARS-CoV-2 infection.

Methods
We established a fixed cohort followed for 12 months in Denmark, Norway, Italy, Luxembourg, Navarre (Spain) and Portugal using routine electronic health registries. The study commenced with paediatric COVID-19 vaccination campaign at each site between June 2021 and January 2022. The outcome was hospitalisation with a laboratory-confirmed SARS-CoV-2 infection or COVID-19 as the main diagnosis. Using Cox proportional hazard models, VE was estimated as 1 minus the confounder-adjusted hazard ratio of COVID-19 hospitalisation between vaccinated and unvaccinated. A random-effects meta-analysis was used to pool VE estimates.

Results
We included 4,144,667 5–11-year-olds and 3,861,841 12–17-year-olds. In 12–17-year-olds without previous infection, overall VE was 69% (95% CI: 40 to 84). VE declined with time since vaccination from 77% ≤ 3 months to 48% 180–365 days after immunisation. VE was 94% (95% CI: 90 to 96), 56% (95% CI: 3 to 80) and 41% (95% CI: −14 to 69) in the Delta, Omicron BA.1/BA.2 and BA.4/BA.5 periods, respectively. In 12–17-year-olds with previous infection, one dose VE was 80% (95% CI: 18 to 95). VE estimates were similar for 5–11-year-olds but with lower precision.

Conclusion
Vaccines recommended for 5–17-year-olds provided protection against COVID-19 hospitalisation, regardless of a previously documented infection of SARS-CoV-2, with high levels of protection in the first 3 months of the vaccination.
Model Pendekatan Komponen Pariwisata 6A Di Desa Mondoluku Menuju Desa Wisata
Authors: Andri Krisna Dianto  , Ardiansyah Hendra Lukmana  , Longinus Lozha  , Rahayu Antasari  
Published: February 2025

Desa Mondoluku untuk menjadi Desa wisata memiliki keberagaman potensi yang belum dikelola secara optimal, maka perlu dilakukan analisis dengan model komponen pariwisata 6A yakni Attraction, Accessibilities, Amenities, Accommodation, Activity dan Ancillary Service sebagai model dalam pengembangan dan pembangunan desa wisata Mondoluku. Kesiapan desa Mondoluku dengan analisis model pendekatan komponen pariwisata 6A, sebagai model pengelolaan dan pengembangan pariwisata di Desa Mondoluku, sehingga pengunjung atau wisatawan dapat menikmati potensi-potensi wista yang ada di Desa Mondoluku, serta diharapkan dapat memberikan peluang pada masyarakat umtuk memanfaatkan potensi-potensi yang ada untuk mendukung keberlangsungan kegiatan pariwisata. Tujuan Penelitian yakni menganalisis model pendekatan komponen pariwisata 6A serta menganalisis faktor pendukung dan penghambat dalam pengembangan desa wisata di Desa Mondoluku menuju desa wisata. Jenis penelitian ini yakni deskriptif kualitatif dengan teknik pengumpulan data dengan observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan pengembangan pariwisata di Desa Mondoluku masih belum optimal, masih ada yang perlu diperbaiki dalam masing-masing komponen pariwisata tersebut pada setiap potensi tempat wisata yang ada di Desa Mondoluku
Effect of temperature, microstructure and intramolecular dynamics of fibrillary collagen on apatitogenesis in scaffolds
Authors: Gaidash A. A. , Kulak A. I. , Krut’ko V. K. , Musskaya O. N. , Kulchitsky V. A. , Skrotskaya K. V. , Kulbitskaya L. V. , Krutsko E. N. 
Published: February 2025

The structure and physicochemical properties of scaffolds obtained from collagen gel using connective tissue sheaths of paravertebral tendons of Wistar rats were studied. The scaffolds were obtained at 37 °C (filmy) and 6 °C (volumetric). During hardening, the scaffolds form globular and extraglomerular fractions, which is typical for collagen gels obtained from tendon membranes. The ratio of the fraction volumes is determined by the pore structure and kinking of collagen fibrils. In the filmy scaffold, closed-type pores with weakened kinking are formed, which leads to the dominance of the extraglomerular scaffold. In the volumetric scaffold, kinking is intensified, open-type pores are formed, which determines the dominance of the globular scaffold. The morphogenetic factors of dominant fraction formation are ordering and increased rigidity, while the subdominant fractions are chaotization and elasticization of collagen frameworks. Fibrillar collagen undergoes extra- and intrafibrillar mineralization in situ with structuring of calcium phosphates along the apatite direction. The micromechanical properties of scaffolds induce extrafibrillar synthesis and determine the direction of apatitogenesis: stoichiometric hydroxyapatite is synthesized on rigid matrices, while carbonate-hydroxyapatites are synthesized on loose ones. Intrafibrillar synthesis in combination with temperature determines the degree of crystallinity and the composition of cationic and anionic sublattices of hydroxyapatites. On matrices of fibrillar collagen with strengthened bonds of peptide and carbonate groups, stoichiometric hydroxyapatite is formed, the degree of crystallinity of which is moderated by temperature − the higher the synthesis temperature, the higher the degree of crystallinity and saturation with calcium would be. On matrices with weakened peptide and C−O bonds, carbonate-hydroxyapatites are formed, in which substitutions in the anionic sublattice are regulated by temperature: at elevated temperatures, CO32– groups predominantly replace OH–, and at lower temperatures, PO43– groups.
Clinical and microbiological characteristics of viral-bacterial pneumonia caused by Klebsiella pneumoniae in SARS-CoV-2 infected patients
Authors: Levchenko K. V. , Mitsura V. М. , Tapalski D. V. , Karpova E. V. , Bondarenko V. N. 
Published: February 2025

The object of study was to investigate the clinical and laboratory characteristics, the outcomes of the disease, the susceptibility to antibiotics and to different combinations in the patients with pneumonia caused by K. pneumoniae associated and not associated with COVID-19.We analysed 93 cases of pneumonia with K. pneumoniae detected in biological materials including 65 ones with COVID-19 and 28 ones without COVID-19.In the both groups, the diseases of the circulatory system and metabolic disorders were the most common concomitant conditions. The laboratory data were not statistically different. The lethal outcomes were found reliably more often in the patients with COVID-19 (66 % vs 32 %). K. pneumoniae was detected predominantly after the tenth day of admission to the hospital (nosocomial strains). In the both groups, the majority of detected K. pneumoniae strains had a multiple resistance to antibiotics. The combinations of antibiotics with no colistin demonstrated a low efficacy, including those with carbapenems. A proportion of 40 (61.5 (48.6–73.3) %) K. pneumoniae samples isolated from patients with COVID-19 had carbopenemases detected.The results of the study refer to the preferability of the colistin comprising the schemes of antibiotics for treatment of pneumonia caused by K. pneumoniae associated and not associated with COVID-19.
Bacterial ligands in complex treatment of community-acquired pneumonia in organized groups
Authors: Kostinov M. P. , Zverev V. V. , Tatevosov V. R. , Gainitdinova V. V. , Polishchuk V. B. , Osiptsov V. N. , Guban’ V. I. , Yastrebova N. E. , Kurbatova E. А. , Markelova E. V. , Shubin I. V. 
Published: February 2025

Despite the successes achieved in treating community-acquired pneumonia (CAP), tactics still need to be improved, especially when forming new organized collectives of military personnel.The purpose of the study was to examine clinical and immunological features of action of an immunotropic drug of bacterial origin Immunovac-VP-4 in complex treatment of mild community-acquired pneumonia in newly recruited military personnel.The study included 35 patients (main group 1) hospitalized with mild CAP who, in addition to basic antibacterial therapy, were treated with the Immunovac-VP-4 vaccine. Control group 2 consisted of 53 patients who received only basic antibacterial therapy. Immunovac-VP-4 contains lysates of Staphylococcus aureus, Klebsiella pneumoniae, Proteus vulgaris, Escherichia coli and was prescribed according to the nasal-subcutaneous regimen from 1 to 13 days of hospital stay. The mechanism of action is based on activating key effectors of innate and adaptive immunity. In the main group there were an increase of respiratory function indicators, production of IgG antibodies to all antigens of the drug, a relative decrease in IL-6 and IFN-γ concentration in blood serum after administration of a bacterial immunomodulator.Including the multicomponent antibacterial vaccine in subcutaneous-nasal regimen in complex treatment of mild CAP can be recommended as one of the treatment methods leading to the normalization of inflammatory mediators and the prevention of respiratory infections in this cohort of patients.
Effect of ascorbic acid on obtaining chondrogenic pre-differentiated mesenchymal stem/stromal cells
Authors: Zhernasechanka H. A. , Isaikina Ya. I. 
Published: February 2025

Mesenchymal stem/stromal cells (MSCs) have unique functional properties, one of which is the chondrogenic differentiation. This population of cells is being used in clinical practice for repairing cartilage tissue. Various combinations of growth factors promote the expression of markers of hyaline cartilage, but also induce hypertrophy’s markers. There is evidence that ascorbic acid can promote chondrogenic differentiation of MSCs by increasing the transcription of Col2, so we have studied when adding ascorbic acid to the differentiation medium to the previously developed cytokine cocktail in order to obtain a hyaline-like matrix. There is a different time of induction of chondrogenesis in MSCs, so we assumed to reduce the induction period of chondrogenic pre-differentiation of MSCs. Based on our studies we confirmed a positive effect of ascorbic acid on the expression of Col2, which indicates the possibility of obtaining strong and stable chondrogenic differentiation of MSCs. The analysis of the expression of genes-markers of chondrogenic differentiation of MSCs and the synthesis of extracellular matrix components on the 4th and 7th days showed a possibility of reducing the pre-differentiation period to 4 days.
Polymorphism of the MMP-2, MMP-9, TIMP-2 genes and the expression pattern of matrix metalloproteinases types 2 and 9 of the placenta of women with recurrent miscarriage
Authors: Grinevich T. N. , Lyalikov S. A. , Shulga A. V. , Kot M. O. 
Published: February 2025

Expression indices of matrix metalloproteinases (MMPs) of types 2 and 9 and polymorphism of MMP-2, MMP-9 and their tissue inhibitor (TIMP-2) genes in placental tissue of women with early reproductive losses were determined. MMP-2 expression in placental tissue preparations was found to be significantly higher among women with recurrent miscarriage in the first trimester pregnancy than in women with normal pregnancy. Associations of the mutant T allele of the 735 C/T polymorphism of the MMP-2 gene and the mutant C allele of the 418 G/C polymorphism of the TIMP-2 gene with a high level of matrix MMP-2 expression were found. The level of MMP-9 expression in the placenta of women with recurrent miscarriage and with physiological pregnancy was not statistically significantly different.
PENYELESAIAN SENGKETA WANPRESTASI PADA PERJANJIAN SEWA MENYEWA PESAWAT ANTARA HELICE LEASING S. A. S DAN ATTERISSAGE S. A. S DENGAN PT. GARUDA INDONESA TBK SECARA ARBITRASE INTERNASIONAL
Authors: Imas Rosidawati Wiradirja  , Amanda  , Eddy Setiawan  , Muhammad Fauzan  , Sugiarto  , Nugraha Pranadita  
Published: February 2025

International trade disputes have been successfully settled by the London Court of International Arbitration (LCIA), a component of the international arbitration system. The decision of a breach of contract dispute involving an aircraft leasing agreement between Helice Leasing S.A.S (Helice) and Atterissage S.A.S (Atterissage) with PT. Garuda Indonesia Tbk (GI), decided by the LCIA, reflects this. After concluding that GI had violated the agreement, the LCIA ordered it to pay Helice and Atterissage the past-due rent as well as the remaining rent. Analysing the international arbitration procedure for resolving disputes and the award's enforcement is the goal of this research. Using a normative legal methodology, the study analyses case studies and legislation. The results show that arbitration uses a multi-step procedure to resolve disputes, including hearings, mediation or conciliation, the selection of an arbitration panel, the presentation of the parties' arguments and supporting documentation, and the arbitrator's ruling. The LCIA effectively resolved the disagreement, demonstrating the efficacy and efficiency of this approach. The enforcement of the award is permitted in Indonesia under Article 65 and Article 66 of Law No. 30 of 1999 on Arbitration and Alternative Dispute Resolution (AAPS Law), provided that the Central Jakarta District Court has recognised the arbitration award and it does not contravene public order.

Keyword : Dispute Resolution; Agreement; Breach of Contract
Test system customization for genotyping the BMP-2 gene 4:28632407 A/G polymorphism in aquacultured rainbow trout
Authors: Nikolaeva O. , Azovtseva A. , Ryabova A. 
Published: February 2025

The application of genomic selection in rainbow trout breeding is becoming more feasible with the advent of recent advances in molecular genetics. However, there are significant challenges in the field of aquaculture, as genomic and marker-assisted selection programmes for aquaculture are considerably behind those for terrestrial farm animals. Currently, there is an actual task to develop test systems for genotyping rainbow trout and for efficient enrichment of target populations with favourable polymorphisms. The objective of this study is to develop a test system based on the promising BMP-2 gene and to establish genomic associations between single nucleotide polymorphism (SNP) and the size-weight characteristics of fish.Materials and methods. The material for the study was comprised of Rofor rainbow trout specimens (n=200), which were evaluated for the following size-weight parameters: fish weight, body length to the end of the caudal fin, length to the end of the scales, head length, height, and body thickness.Results. The results of the study revealed that the overwhelming majority of fish (98 %) exhibited a heterozygous genotype (AG) while homozygous genotype AA was entirely absent from the sample. The analysis did not identify any notable correlations between size-weight parameters but a potential explanation for this could be the absence of the AA genotype within the population. Nevertheless, the test system was successfully developed and validated. The study of the influence of this polymorphism contributed to the knowledge of rainbow trout genetics. Further application of the developed test system in rainbow trout breeding programs is possible after conducting additional studies to identify economically useful genetic associations in larger samples of individuals.
Analysis of the breeding and productive qualities of the Black-and White breed of cattle in the Russian Federation
Authors: Petrova A. , Tulinova O. 
Published: February 2025

The purpose of the study is to monitor and analyze the breeding and productive qualities of Black-and-White cattle in the Russian Federation.Materials and methods. The object of the study was digital data on the number, economically useful traits, breeding qualities of cattle and cows of Black-and-White, Holstein and other dairy breeds bred in the Russian Federation. The main method is monitoring and analysis of data in a comparative aspect with Holstein and other breeds of the Russian Federation.Results. Analysis of the relative number of livestock by breed showed that among the 25 breeds assessed, the Black-and-White breed in this aspect takes second place (17,62%), and 4th in milk productivity. Animals of the 1st and 2nd lactation of this breed make up 62,4 % (n=161302), which indicates that this population is quite young. The average age of cows is 2,5 calvings, and the number of heifers transferred to the main herd is 32,8 % (n=84783). The milk flow rate, with the desired indicator (from 2,0 kg/min. and above) was detected in 56,8% (n=51652). An analysis of 526 farms for insemination of 258,543 cows and 114,745 heifers showed that only 88,8 % of them were inseminated (n=331,685), including 97,7 % artificially. 43,6 % of cows and 46,6 % of heifers were inseminated with improvement bulls. The average live weight of cattle at the first insemination was 386 kg. The average days open of the assessed livestock was 132 days. Extended days open (121 days or more) were detected only in 37,2 % of animals (n=82,536), which indicates good reproductive qualities of Black-and-White cows. The average dry period is 61 days, that is, it has an optimal value, but in 13 % of animals an extended dry period of more than 71 days was detected. The yield of live calves per 100 cows was 76 %. In total, during the reporting period, 4,686 heads of breeding cattle of the Black-and-White breed were sold, of which 4,616 heifers and 50 bulls were young animals.Conclusion. The monitoring of the state of the breeding and productive qualities of Black and-White cattle in the Russian Federation showed that this population of dairy cattle is not only the second largest among all breeding dairy breeds, but also makes up almost half of the dairy cattle of the remaining 24 breeds, with the exception of Holstein. In terms of milk yield, Black and-White cows exceed the average for 23 breeds, except Holstein, by 300-500 kg of milk, but are inferior in quality indicators.