bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Anatomy of the Frontal Process of the Maxilla in the Medial Wall of the Lacrimal Drainage System in East Asians
Authors: Chen Zhaoyue , Wang Peng , Du Lei , Wang Lan 
Published: November 2020

Purpose:
To investigate the anatomical structure characteristics of the frontal process of the maxilla in the medial wall of the lacrimal drainage system for endoscopic dacryocystorhinostomy based on the cone-beam computed tomography images.

Methods:
One hundred eight sides of orbits were retrospectively evaluated in this study. The angulation and thickness of the frontal process of the maxilla in the medial wall of the lacrimal drainage system were measured and compared at 2 different levels: lacrimal sac level and nasolacrimal duct level. The vertical height between the 2 measurement levels was also measured. Data were compared between males and females.

Results:
The average angulation and thickness of the frontal process of the maxilla were found significantly larger at the lacrimal sac level than at the nasolacrimal duct level (83.1 ± 11.3° vs. 61.7 ± 10.9° and 2.7 ± 0.9 mm vs. 1.1 ± 0.4 mm) (p < 0.001). The vertical height between the 2 levels was significantly higher in males than in females (8.6 ± 1.8 mm vs. 7.8 ± 1.7 mm) (p = 0.015).

Conclusions:
We found the angulation and thickness of the frontal process of the maxilla in the medial wall of the lacrimal drainage system decreased from the upper to the lower level. Starting the osteotomy during endoscopic dacryocystorhinostomy might be easier and safer at the midpoint level of the maxillary line.
Expression Changes of Serum IL-1α, CCL2, and CXCL2 in Patients With Pemphigus
Authors: Mao Li-Dan , Zhang Yu , Liang Jun-Qin , Kang Xiao-Jing , Hu Feng-Xia , Jiang Fan-He 
Published: November 2020

Objective:
This study was performed to explore the possible changes of the serum levels of the cytokines including interleukin 1α (IL-1 α), chemokine monocyte chemotactic protein 1 (also known as chemokine [C-C motif] ligand 2 [CCL2]), and C-X-C motif chemokine ligand 2 (CXCL2) in patients with pemphigus.

Methods:
The expression levels of IL-1 α, CCL2, and CXCL2 in the serum of 57 patients with pemphigus PV (including 42 patients in progressive stage and 15 patients in remission stage) and 31 healthy controls were examined by enzyme-linked immunosorbent assay. The indepent-samples t-test was used to compare the two groups. One-way analysis of variance was used for multiple-group comparisons, and the post-hoc least significant difference test was used to detect differences among multiple groups.

Results:
The serum expression levels of CCL2 and IL-1a were all significantly higher in the patients in progressive stage than in the controls ([2.69 ± 0.23] ng/mL vs. [2.55 ± 0.28] ng/mL, P = 0.043; [0.62 ± 0.27] ng/mL vs. [0.48 ± 0.23] ng/mL, P = 0.038, respectively). In addition, the serum expression level of CXCL2 was significantly higher in patients in progressive stage than in in the remission stage ([61.70 ± 46.38] ng/mL vs. [24.97 ± 18.46] ng/mL, P = 0.037). Sex, disease classification, disease severity, treatment, and mucosal involvement had no significant influence on the expression of IL-1 α, CCL2, or CXCL2 in the serum of patients groups and controls (all P > 0.05).

Conclusion:
IL-1 α, CCL2, and CXCL2 are heavily involved in the occurrence and development of pemphigus and may be related to the activity of the disease.
Role of Epigenetics in the Pathogenesis of Systemic Sclerosis
Authors: Liu Chao-Fan , Tang Jia-Xuan , Zhu Lu-Bing , Li Ming 
Published: November 2020

Abstract
Systemic sclerosis (SSc) is characterized by immune dysfunction, vasculopathy, chronic fibrosis of skin and internal organs with complex etiology. With the rapid development and the application in biomedicine of epigenetics, accumulating evidence has shown that epigenetics plays an important role in the pathogenesis of SSc. Environmental factors via epigenetics are needed to trigger and maintain for the disease in the subjects with genetic predisposition to SSc. The role of epigenetics in the pathogenesis of SSc includes hypermethylation of the promoter region of nitric oxide synthase and bone morphogenetic protein receptors II, up-regulation of histone deacetylases 4 and 5 expression, and down-regulation of miR-193b and miR-152 in endothelial cells inducing vascular dysfunction; DNA hypermethylation and hypoacetylation of histone H3 and H4 in Friend leukemia virus integration 1 and Kruppel-like factor 5 genes, and the abnormal expression of miR-29, miR-129-5p and miR-135b in fibroblasts causing excessive fibrosis; DNA hypomethylation in the promoter regions of CD11a and CD70 genes in CD4+T cells resulting in immune dysfunction. Studies on the role of epigenetics in SSc are of great significance for better understanding the pathogenic machanism of SSc, which is helpful to find new molecular targets for treating SSc, and consequently, improve the prognosis of SSc.
Knowledge and Attitudes Regarding Organ Transplantation Among Cyprus Residents
Authors: ASIMAKOPOULOU Evanthia , STYLIANOU Vaso , DIMITRAKOPOULOS Ioannis , ARGYRIADIS Alexandros , BELLOU–MYLONA Panagiota 
Published: November 2020

ABSTRACT

Background
Organ transplantation was one of the greatest achievements of medical science during the 20th century. Knowledge, education, and culture all play prominent roles in transplantation because of the complexity of the process from donation to transplantation.

Purpose
The aim of this research was to determine and analyze the knowledge and attitudes about organ donation and transplantation among the general population in Limassol, Cyprus.

Methods
A quantitative research approach was followed, and a questionnaire consisting of closed-ended questions was completed by adults from the general population in Limassol.

Results
One thousand two hundred adults out of the 1,346 adults who were contacted responded to the survey (response rate: 89%) and were included as participants. Of the participants, 93.4% (p < .05) considered organ donation to be lifesaving, 57% expressed interest (and 39.8% expressed disinterest) in becoming organ donors, 80.6% (p < .05) expressed awareness of there being a waiting list for people in need of organ transplantation, 50.4% agreed that brain death must be confirmed before organ removal for transplantation, and 47% recalled having been informed about organ donation through the media, with 31.5% stating that they had never been informed about organ donation.

Conclusions
The participants demonstrated limited awareness regarding the organ donation system in Cyprus. Furthermore, a significant percentage stated that they lacked a source for obtaining related information. The Cypriot society should be informed and encouraged to participate in organ donation to increase the rate of organ transplantation.
Helpfulness of Workplace Accommodations in Maintaining Health and Work Ability in Older Employees with Poor Health in Germany
Authors: Dettmann Marieke-Marie , Hasselhorn Hans Martin 
Published: November 2020

Objective:
Supporting employees with health impairments to stay at work through workplace accommodation is a well-researched topic. However, research on workplace accommodations for older employees is lacking.

Methods:
Cross-sectional data from the German lidA cohort study in 2018 focusing on older employees who reported poor health (n = 421) was analyzed. A multiple logistic regression analysis was conducted to asses a potential association between the accommodation type and perceived helpfulness of workplace accommodations in older employees with poor health.

Results:
Changes in working times (OR 6.59), in work tasks (OR 3.50) and in the workplace (OR 2.57) were perceived as most helpful.

Conclusion:
The results indicate that workplace accommodations can be helpful in older employees with health impairments and that this is not by chance, but that the perceived effectiveness has determinants and can be influenced.
Stress Management and Resiliency Training for Healthcare Professionals
Authors: Dossett Michelle L. , Needles Emma W. , Nittoli Caroline E. , Mehta Darshan H. 
Published: November 2020

Objective:To assess the effects of a multi-modal resilience program, the Stress Management and Resiliency Training (SMART) Program, on healthcare professional well-being and job satisfaction.Methods:This pilot, mixed-methods, quality improvement, cohort study assessed perceived stress, physical and mental health, job satisfaction, burnout, and value of the curriculum to attendees.Results:Participants experienced a significant reduction in perceived stress (P < 0.001) and significant improvements in global mental health (P = 0.001), physical health (P = 0.045), and job satisfaction (P = 0.047). There was no significant improvement in burnout. Qualitative analysis of free text responses revealed appreciation for the skills taught, increased resiliency, and a positive impact on relationships.Conclusions:Delivering the SMART Program to healthcare professionals is feasible and may serve as a useful tool for reducing stress and increasing resilience.
Genetic Variation Associated With Depressive Symptoms in Breast Cancer Patients
Authors: Bayer Samantha J. , Yang Gee Su , Lyon Debra E. 
Published: November 2020

Background
Depressive symptoms are highly prevalent in breast cancer patients. These symptoms can contribute to lower treatment adherence, increased healthcare charges, and higher mortality rates. Growing evidence suggests that genetic variations may be associated with depressive symptom susceptibility.

Objective
To comprehensively review current findings on the association of genetic variations with depressive symptoms in breast cancer patients.

Methods
A literature search was conducted using keywords such as gene variation, single-nucleotide polymorphism, depression/depressive symptoms, and breast cancer. Four hundred articles were retrieved from PubMed, Web of Science, CINAHL, and PsycINFO, yielding 9 full-text, data-based articles. The study quality was assessed using the STrengthening the REporting of Genetic Association studies guideline.

Results
Genetic polymorphisms in brain-derived neurotrophic factor (BDNF), interferon γ receptor 1 (IFNGR1), interleukin-6 (IL-6), tumor necrosis factor α (TNFA), and IL-1B were found to be associated with depressive symptoms among breast cancer patients. The role of serotonin transporter gene linked promotor region (5-HTTLPR) functional polymorphisms on depressive symptoms was inconclusive. The overall quality of reporting results and methods was medium.

Conclusions
This is the first review of genetic variations related to differences in levels of depressive symptoms among breast cancer patients. Genetic polymorphisms in inflammatory, neuronal system, and signal transduction pathways can influence the susceptibility. However, more research regarding this topic is needed to further clarify genetic risk factors.

Implications for Practice
Healthcare providers may determine patients at higher risk of developing depression and symptom outcomes if genetic biomarkers with good sensitivity/specificity are provided. This knowledge can potentially help the development of personalized treatment and decision making for those patients.
Are Physical Activity and Sedentary Behavior Associated With Cancer-Related Symptoms in Real Time?
Authors: Paxton Raheem J. , Bui Chuong , Fullwood Dottington , Daniel Danielle , Stolley Melinda , Oliver JoAnn S. , Wang Kun , Dubay John W. 
Published: November 2020

Background
Few studies have examined the real-time and dynamic relationship between lifestyle behaviors and treatment-related symptoms.

Objective
The aim of this study was to examine the associations of daily physical activity and sedentary behavior with symptom burden, pain interference, and fatigue among patients who were undergoing active cancer treatment.

Methods
A total of 22 (mean age = 57 years; 73% women; 55% Black) cancer patients were recruited from a local hospital and reported a daily diary of physical activity, sedentary behavior, symptom burden, pain interference, and fatigue over 10 days. Adjusted mixed-effects models were used to examine all associations.

Results
Body mass index moderated the relationship between physical activity and symptom burden (γ = 0.06, P < .01) and physical activity and fatigue (γ = 0.09, P < .05). On days where physical activity was higher than average, symptom burden and fatigue scores were lower among patients who had lower body mass index values. Also, age moderated the relationship between sedentary behavior and symptom burden (γ = −0.04, P < .05); on days where patients sat more, symptom burden was lower among patients who were younger than the average age.

Conclusions
Overall, these data indicate that treatment-related symptoms vary daily within cancer patients and that physical activity may alleviate treatment-related symptoms for leaner patients. Larger samples and objective assessments of physical activity and sedentary behavior are needed to validate our results.

Implications for Practice
Oncology nurses may be in the best position to promote physical activity during treatment as a strategy to manage symptom burden.
Progress toward integrating Distress as the Sixth Vital Sign: a global snapshot of triumphs and tribulations in precision supportive care
Authors: Fradgley Elizabeth A. , Bultz Barry D. , Kelly Brian J. , Loscalzo Matthew J. , Grassi Luigi , Sitaram Brindha 
Published: November 2020

Abstract

Background:
The International Psycho-Oncology Society (IPOS) recognizes psychosocial cancer care as a universal human right. IPOS emphasized that distress should be measured as the 6th Vital Sign alongside temperature, blood pressure, pulse, respiratory rate, and pain. To date, >75 cancer care organizations and accreditation bodies have endorsed screening, monitoring, and treating the multifactorial symptoms of distress as an essential component to high-quality care. The degree to which this international commitment has translated into the integration of precision supportive care within clinical settings is unknown.

Methods:
Building upon a 2018 IPOS World Congress Symposium, this commentary provides 4 snapshots into the progress made toward integrating precision supportive care in India, Australia, Europe, and the United States. The commentary demonstrates the different approaches taken to develop screening practices or overcome barriers to comprehensive precision supportive care.

Results:
Although psychosocial cancer care is a universal right, service and patient barriers to implementation remain, such as: inadequate workforce distribution and service investment in psychosocial care; siloed teams and limited communication skills; and cultural challenges. Recurrent themes emerged which can be used to invigorate commitment to IPOS standards: ongoing capacity building of the international psycho-oncology community; supporting communication skills training and encouraging programmatic thinking within services; and advocating for ongoing investment in precision supportive care through evaluation and strong clinical leadership.

Conclusions:
In examining 4 unique settings, the commentary recognizes the geographic variation in health care resources and social contexts of cancer care alongside cultural perspectives on psychosocial distress, screening methods, and the value of precision supportive care.
The Psychological Impact of Cancer (PIC) Scale: development and comparative psychometric testing against the Mini-MAC Scale in UK and Australian cancer survivors
Authors: Hulbert-Williams Nicholas J. , Hulbert-Williams Lee , Whelen Liz , Mulcare Hunter 
Published: November 2020

Abstract

Background:
Clinicians and researchers make considerable use of both the Mental Adjustment to Cancer (MAC) Scale, and the shorter Mini-MAC, to measure psychological adjustment in cancer patients. The length of the scale is problematic when used clinically, and its psychometric properties have been criticized. This article presents two studies leading to the development of a novel scale, the Psychological Impact of Cancer (PIC) Scale, using items drawn from the MAC.

Methods:
Study 1 used standard item-reduction techniques to shorten the Mini-MAC in a sample of 160 cancer patients of mixed diagnosis, recruited an average 46 days post-diagnosis. This resulted in a 12-item scale with a 4-factor structure, similar to that derived from a 2012 re-analysis of the Mini-MAC. Study 2 presents confirmatory factor analysis (CFA) of this new measure and tests its construct validity and test–retest reliability in a sample of 183 mixed cancer survivors.

Results:
This study indicated that the shorter scale performed well on CFA indicators (RMSEA = .083; ECVI = .923; PNFI = .604; AGFI = .857) and tests of internal consistency (all >.623), and comparable concurrent validity with longer versions. The 4 factors were labeled cognitive distress, cognitive avoidance, emotional distress, and fighting spirit.

Conclusions:
Given its shorter length and acceptable psychometrics, the PIC offers a useful clinical and research tool to assess the psychological impact of cancer. Psychometric properties of one subscale (fighting spirit) remain poor, but no worse than in the original scale; directions for further development of the scale are described.
Psychological distress in newly diagnosed breast cancer patients: an observational study comparing those at high risk of hereditary cancer with those of unknown risk
Authors: Wevers Marijke R. , Schou-Bredal Inger , Verhoef Senno , Bleiker Eveline M.A. , Hahn Daniela E.E. , Brouwer Titia , Kieffer Jacobien M. , Ausems Margreet G.E.M. , Aaronson Neil K. 
Published: November 2020

Abstract

Background:
We compared levels of psychological distress of newly diagnosed breast cancer patients who knew they were at heightened risk of carrying a BRCA1/2 mutation (HRBC) (eg, because of young age at diagnosis and/or a positive family history) with breast cancer patients who were not assessed for their risk (unknown risk breast cancer, or URBC).

Methods:
We administered the Hospital Anxiety and Depression Scale (HADS) to a sample of 238 Dutch HRBC patients and 165 Norwegian URBC patients within 3 weeks of breast cancer diagnosis, prior to primary surgery. We compared HADS scores between these groups, and identified variables associated with those scores.

Results:
The HRBC patients reported significantly more symptoms of depression than URBC patients (P < .001, effect size = .40). The percentage of women with a suspected or probable (HADS depression score ≥8) and a probable diagnosis of depression (HADS depression score ≥11) was 29% versus 12% (P = .001) and 15% versus 5% (P = .01) in the HRBC and URBC groups, respectively. There were no significant group differences in HADS anxiety scores. In the HRBC sample, having children and psychological problems in the year before breast cancer diagnosis were associated significantly with both depression and anxiety following the diagnosis of breast cancer.

Conclusions:
Shortly after diagnosis, high hereditary-risk breast cancer patients report significantly higher levels of clinically relevant depressive symptoms as compared to breast cancer patients not assessed for their risk. Screening for psychological distress among high-risk breast cancer patients could facilitate timely referral to appropriate psychosocial services.
Online psychological self-management intervention for testicular cancer survivors (e-TC 2.0): promising acceptability and preliminary efficacy, but limited feasibility
Authors: Smith Allan ‘Ben’ , Rincones Orlando , Heiniger Louise , Grimison Peter , Tran Ben , Stockler Martin R. , Toner Guy , Cohen Beth , Olver Ian , Klein Britt , McJannett Margaret , Butow Phyllis 
Published: November 2020

Abstract

Background:
Testicular cancer (TC) survivors experience greater psychological morbidity than the general population. Two-thirds of TC survivors report unmet supportive care needs regarding issues such as fear of cancer recurrence (FCR), but many are reluctant/unable to seek face-to-face help. This study prospectively assessed the feasibility, acceptability, and preliminary efficacy of an interactive web-based self-management intervention (e-TC 2.0) in reducing borderline/clinical levels of anxiety, depression, and/or FCR among TC survivors.

Methods:
TC survivors who had completed treatment were recruited to this single-arm phase I trial through clinicians and online advertisements. Consenting participants completed baseline questionnaires, had 12 weeks’ access to e-TC 2.0, then completed post-intervention questionnaires. Feasibility was determined by the proportion of e-TC 2.0 completed (website usage data). Acceptability was assessed with purpose-designed satisfaction measures. Preliminary efficacy was indicated by changes in anxiety/depression (HADS), distress (thermometer), and FCR (Fear of Cancer Recurrence Inventory-Short Form).

Results:
Thirty-nine participants started the intervention; 48% completed the first module, but only 20% completed all modules. Mean participant age was 37.1 years; mean time since diagnosis was 3.6 years. Mean acceptability scores were > 8/10. Mean unmet needs, distress, FCR, anxiety, and depression levels decreased after the intervention, as did the proportion of participants above clinical cut-offs.

Conclusions:
e-TC 2.0 is the first web-based resource for TC survivors with borderline/clinical levels of anxiety, depression, and/or FCR. Although engagement with e-TC 2.0 was somewhat limited, website users reported high levels of satisfaction and reductions in psychological morbidity and unmet needs. e-TC 2.0 may be a useful adjunct to traditional face-to-face health professional support for TC survivors.
Exploring the Survivorship Experiences and Preferences for Survivorship Care Following Testicular Cancer: A Mixed Methods Study
Authors: Petrella Anika R. , Sabiston Catherine M. , O’Rourke Roxy H. , Santa Mina Daniel , Matthew Andrew G. 
Published: November 2020

Abstract

Background:
Men with testicular cancer are an understudied subgroup of survivors due to a lack of engagement in supportive care research and usual care despite reporting unmet support care needs. The present study aimed to explore the survivorship experience of men with testicular cancer, as well as survivors’ attitudes toward, and preferences for, sport-based supportive care programming.

Methods:
Using a concurrent mixed methods approach, semistructured interviews with a convenient sample of testicular cancer survivors (n = 11) were conducted, along with a cross-sectional survey (n = 135) completed during routine oncology visits.

Results:
Inductive thematic analysis of qualitative data resulted in three core themes labeled “the developmental disruption," “the connectedness conflict," and “the way back to normal." Based on the descriptive analysis of survey data and qualitative feedback, testicular cancer survivors indicated preferences for sport-based supportive care programming that is offered outside of the hospital, in the evening, include a strength training component, and embedded psychoeducation throughout addressing common survivorship concerns related to physical health (eg, fertility and fatigue), managing emotions (eg, anxiety and low mood), and getting back on track.

Conclusions:
Findings from this study provide a foundation for the development of a gender-sensitized supportive care program tailored to the survivorship profile of men with testicular cancer.