bluuebunny/crossref_metadata_2025_split huggingface dataset:
Education Research in German Non-Medical Health Care Professions compared to International Developments: a Bibliometric and Content-Related Publication Analysis
Authors: Kuka Sandra , Ehlers Jan P. , Zupanic Michaela 
Published: February 2020

Abstract
Background In Germany academic degree programs for non-medical health care professions (nursing, physical, occupational and speech language therapy, midwifery) have been established only recently, even if they play a key role in today´s complex patient-centered health care. The aim of this study was to evaluate the development and current state of German education research in these professions as well as to conduct a comparison to international research activities in this field.Method To achieve these objectives a bibliometric and content-related publication analysis was performed from 2008 to 2017 in four international high-impact journals. Based on appropriate inclusion criteria (bibliographical and biographical criteria, focus on first and last author, original study) and their development into a coding scheme, articles were recorded systematically and results analyzed quantitatively and content-wise. Group comparisons between German and international health care professions as well as interdisciplinary comparisons between the individual professions were performed.Results On the whole, 11.891 articles were analyzed for participation of the respective target groups, either as first or as last author. Of these, 164 original studies met the inclusion criteria with 157 publications pertaining to international and only seven to German health care professionals. The majority of authors belonged to the discipline of nursing science (n=138). North America (36.63%), Australia (18.32%) and Asia (14.85%) rank among the regions that publish most frequently. Publications by German health care professionals are rare but showed an overall high level of quality.Conclusion International publication activities by non-medical health care professionals have been on the rise in recent years. Specific funding measures as well as transnational and interdisciplinary collaborations may be potential ways of strengthening and expanding education research in countries with only young academic experiences.
Efficacy and safety of Chinese herbal medicine Guanxinshutong capsule for the treatment of chronic heart failure with ejection fraction decrease (&lt;50%) caused by coronary heart disease: study protocol for a randomized controlled trial
Authors: Wang Yu , Xu Jiaping , Yang Jie-hong , Zhang Ling , Pan Yuan-jiang , Dou Li-ping , Zhou Peng , Xu Yi-zhou , Li Chang , He Yu , Zhou Hui-fen , Yu Li , Chen Jing-wen , Huang Shu-wei , Fu Wei , Wan Hai-tong 
Published: February 2020

Abstract
Background Chronic Heart failure (CHF) is a global epidemic and common cardiovascular disease with high mortality and poor prognosis, which bring heavy burdens to society and family. Traditional Chinese medicine (TCM) has been extensively used in China as an adjunct treatment for CHF. Guanxinshutong capsule (GXST), approved by the China Food and Drug Administration (CFDA) in 2002 (No. Z20020055), is commonly used Chinese herbal medicine (CHM) for the treatment of coronary heart disease (CHD) currently. Both experimental research and small-sample clinical trials have shown that GXST could attenuate CHF. However, the effects of GXST on CHF as an adjunct therapy are lack of high-quality clinical evidence. This study is a large-scale, multi-center, double-blinded clinical trial to explore the efficacy and safety of GXST in CHF with ejection fraction decrease (<50%) caused by CHD. Methods This study is a multi-center, randomized, double-blind, placebo-controlled clinical trial. After 1week baseline period, a total of 480 participants will be randomly assigned to the intervention group and placebo group in ratio 2:1. Based on routine medications, the intervention group will be treated with GXST while the control group will be treated with placebo (both 0.3g/capsule, op, 3 capsules/time, thrice daily) for 12 weeks, and then be followed-up for another 40 weeks. The primary outcome is the effect of 6 min walk test (6MWT). The secondary outcomes include NT-proBNP, classification of the New York Heart Association (NYHA) heart function, Minnesota heart failure quality of life scale (MLHFQ), echocardiographic parameters, blood stasis syndrome symptom scale and clinical endpoint events. Metabolomics and proteomics will also be assessed. Adverse events (AEs) will be monitored throughout the trial. All the data will be recorded in electronic case report forms (eCRF) system database and analyzed in accordance with a predefined statistical analysis plan. Ethical approval of this trial has been granted by the Research Ethics Committee of the Second Affiliated Hospital of Zhejiang Chinese Medical University (ID: 2019-Y-003-02). Written informed consent of patients will be required. The results will be disseminated to the public through peer-reviewed journals and academic conferences. Discussion This study integrates the advantages of TCM and western medicine in the treatment of CHF, the result of this study will offer the efficacy and safety evidence of GXST on CHF with ejection fraction decrease (<50%).
Development and evaluation of an eHealth self-management intervention for chronic kidney disease patients in China: protocol for a mixed-method hybrid type 2 trial
Authors: Shen Hongxia , Kleij Rianne van der , Boog Paul JM van der , Song Xiaoyue , Wang Wenjiao , Zhang Tongtong , Li Zhengyan , Lou Xiaoping , Chavannes Niels 
Published: February 2020

Abstract
Background Chronic kidney disease (CKD) is a significant public health concern. In CKD patients, interventions that support disease self-management have shown to improve health status and quality of life. At the moment, the use of electronic health (eHealth) technology in self-management interventions is becoming more and more popular. Evidence suggests that eHealth-based self-management interventions can improve CKD patients’ health-related outcomes. However, knowledge of the implementation and effectiveness of such interventions in general, and in China in specific, is still limited. This study protocol aims to develop and tailor the evidence-based Dutch ‘Medical Dashboard’ eHealth self-management intervention for patients suffering from CKD in China and evaluate its implementation process and effectiveness. Methods To develop and tailor a Medical Dashboard intervention for the Chinese context, we will use an Intervention Mapping (IM) approach. A literature review and mixed-method study will first be conducted to examine the needs, beliefs, perceptions of CKD patients and care providers towards disease (self-management) and eHealth (self-management) interventions (IM step 1). Based on the results of step 1, we will specify outcomes, performance objectives, and determinants, select theory-based methods and practical strategies. Knowledge obtained from prior results and insights from stakeholders will be combined to tailor the core interventions components of the ‘Medical Dashboard’ self-management intervention to the Chinese context (IM step 2-5). Then, an intervention and implementation plan will be developed. Finally, a 9-month hybrid type 2 trial design (N=60) will be employed to investigate the effectiveness of the intervention using a pilot randomized controlled trial with two parallel arms, and the implementation integrity (fidelity) and determinants of implementation (IM step 6). Discussion Our study will result in the delivery of a culturally tailored, standardized eHealth self-management intervention for CKD patients in China, which has the potential to optimize patients' self-management skills and improve health status and quality of life. Moreover, it will inform future research on the tailoring and translation of evidence-based eHealth self-management interventions in various contexts.
Psychosocial distress associated with work-related musculoskeletal disorders: A qualitative study
Authors: Alnaser Musaed 
Published: February 2020

Abstract
Background Millions of working hours are lost globally as a result of work-related musculoskeletal disorders (WMSDs). American health care professionals spend approximately 13 days away from work as a result of such injuries. There is a significant body of research on the different ways in which psychosocial factors contribute to the cause of WMSDs. However, there is insufficient evidence on the psychosocial distress acquired by WMSDs and their effect on an individual’s overall health and wellbeing. The purpose of this study was to investigate psychosocial distress among workers with WMSDs from different occupational fields.Methods A phenomenological qualitative approach was used. Eight participants with work injuries were interviewed. The interview guide comprised eight semi-structured, open-ended questions. Phenomenological analysis was used to develop patterns, categories, and themes.Results Analysis of the interviews revealed three themes: the materiality of work, development of psychosocial distress, and adaptation strategies. Participants demonstrated positive working attitudes, values, and beliefs. Work provided a sense of self-worth and meaning to life. However, work injuries disrupted and challenged all aspects of the participants’ lives including work, home, family, and personally, resulting in psychosocial distress.Conclusion This study concludes that WMSDs could negatively affect the psychosocial health of workers. Depending on the severity of WMSDs and the significance of materiality of work, the amount and magnitude of psychosocial distress occur accordingly. Individual attempts using different adaptation strategies to regain control over the environment are required to reduce psychosocial distress and physical symptoms, promote family stability, and perform expected roles and responsibilities. Employers should develop and carry out health promotion programs to improve the health and well-being of people at work.
Correlations between Cortical and Locomotor Muscle in the Seven Gait Phases during Treadmill Walking
Authors: Wei Pengna , Zhang Jinhua , Wang Baozeng , Hong Jun 
Published: February 2020

Abstract
Background: Previous researchers have found that cortex is involved in the regulation of treadmill walking. However, cortico-muscular interaction analysis in a ‘fine’ gait phase (such as seven phases of the gait cycle) remains lacking in the time-frequency domain.
Methods: In this investigation, we used beta band electroencephalogram (EEG) data to find that eight muscle-related cortices are inconsistent at the end of the swing and stance phases. The eight muscle-related cortices differ at each phase according to gamma band EEG data. Firstly, slope sign change (SSC) and mean power frequency (MPF) features of EEG and surface electromyography (sEMG) were used to recognize the seven gait phases, which are loading response (LR), mid-stance (MST), terminal stance (TST), pre-swing (PSW), initial swing (ISW), mid-swing (MSW) and terminal swing (TSW). Following this, the time-frequency cross mutual information (TFCMI) method, a novel time-frequency analysis method, was applied to examine the eight muscle-related cortices in seven gait phases using beta and gamma band EEG data.
Results: We firstly found that the feature set comprising SSC of EEG as well as SSC and MPF of sEMG was available for seven gait phases recognition, and secondly that TFCMI values between each sEMG channel and EEG differed significantly in the seven gait phases.
Conclusions: This suggests that analysis of the seven gait phases is beneficial. These insights enrich previous findings from authors carrying out cortico-muscular interaction analysis as well as providing critical information for rehabilitation physicians.
The Effect of Adding Calcitonin Gene-Related Peptide Monoclonal Antibodies to Onabotulinum Toxin A Therapy on Headache Burden: A Retrospective Observational Study
Authors: Ozudogru Seniha , Bartell Jared , Yuan Heidi , Digre Kathleen , Baggaley Susan 
Published: February 2020

Abstract
Background The calcitonin gene-related peptide monoclonal antibody medications represent a novel and effective group of treatment options that can be added on to existing regimens such as onabotulinum toxin A injections for the treatment of refractory chronic migraine. Mechanistically, calcitonin gene-related peptide antibodies have been shown to inhibit Aδ fibers while onabotulinum toxin A modulates C fibers. Due to the differing loci of effect and anecdotal observations, a synergistic effect between these therapies is a theoretical possibility. The aim of this study was to investigate this relationship. Methods Patients from the University of Utah Headache Clinic having received at least two rounds of injections of onabotulinum toxin A who responded partially but not completely to therapy were started on a calcitonin gene-related peptide antibody medication. The patients’ responses to a brief headache burden questionnaire prior to their onabotulinum toxin A administration at the time of each visit were collected. Parameters we monitored included the number of headaches experienced while receiving onabotulinum toxin A therapy, the initial timing of the of the wear off period, and the number of headaches after that the wear off period began. Results Half of the 36 patients included in the study demonstrated an improvement in their headache burden based on at least one parameter from their questionnaire. These 18 patients reported an average increase of 2.0 additional weeks for the beneficial effects of the onabotulinum toxin A to wear off. Twelve patients reported no change in onabotulinum toxin A efficacy while 6 patients showed greater headache burden or lower onabotulinum toxin A treatment efficacy following the initiation of one of the monoclonal antibodies. Conclusions Our study highlights the potential of calcitonin gene-related peptide monoclonal antibodies to serve as an effective add-on therapy for chronic migraine patients receiving onabotulinum toxin A injections, especially those designated “responders” but still experiencing the drug wear off prior to the next round of injections. Larger sample sizes and more frequent at-home questionnaire data are needed to corroborate these results.
CYPB upregulates and promotes cell proliferation in endometrial carcinoma
Authors: Liu Jing , Zuo Ying , Qu Gui-Mei , Song Xiao , Liu Zhong-Hui , Zhang Ting-Guo , Zheng Zhu-Hua , Wang Hong-Kun 
Published: February 2020

Abstract
BACKGROUND

The molecular pathogenesis of endometrial cancer is not yet completely understood, preventing the development of successful therapies. Here, we determine the effect of CYPB on the growth of endometrial cancer.

METHODS

In this study, we examined the expression of CYPB in endometrial cancer tissues using immunohistochemistry. CYPB silencing in the human cell line HEC-1-B was used to evaluate the role of CYPB in the malignant phenotype of endometrial tumor cells, while CCK-8 and colony formation assays were performed to assess its effect on tumor cell proliferation. Furthermore, microarray analysis was carried out to compare the global mRNA expression profile between the normal and CYPB-knockdown cell. Gene ontology and KEGG pathway enrichment analysis were performed to determine the potential function of different expressed genes related to CYPB.

RESULTS

We found that CYPB was upregulated in endometrial cancer, while cells with suppressed expression of CYPB exhibited markedly reduced migration. We identified 1536 differentially expressed genes (onefold change, p< 0.05), among which 652 genes were upregulated and 884 genes were downregulated, and most of them were enriched in cell cycle, glycosphingolipid biosynthesis, adherens junctions, and metabolism pathways.

CONCLUSIONS

The results of our study suggest that CYPB may serve as a novel regulator of endometrial cell proliferation, thus representing a novel target for gene-targeted endometrial therapy.
Effect of High Body Mass Index on Short- and Long-term Outcomes of Patients who Underwent Laparoscopic Gastrectomy for Advanced Gastric Cancer: A Case Control Study
Authors: Luo Tianqi , Chen Guoming , Liang Chengcai , Jiang Kaiming , Lei Kai , Yuan Shuqiang , Qiu Haibo , Liang Yao , Chen Ying-Bo 
Published: February 2020

Abstract
Background High body mass index (BMI) is thought to be a preoperative risk factor for surgical treatment. Until now, few studies have investigated the long-term impact of preoperative high BMI on advanced gastric cancer (GC) patients who underwent laparoscopic gastrectomy (LG). Therefore, the present study was designed to compare clinical outcomes between high BMI and normal BMI patients who underwent LG. MethodsWe retrospectively investigated 282 pathological stage II~III GC cases who underwent radical LG plus D2 lymphadenectomy from February 2009 to May 2018. Based on the China BMI classification, the patients were classified into a high (BMI ≥ 24 kg/m2) or normal (BMI < 24 kg/m2) BMI group. The clinical characteristics, intraoperative findings, short-term and long-term outcomes of the two groups of patients were then compared. Results The high BMI group had longer operation time (160.1 ± 36.0 minutes vs. 147.7 ± 33.7 minutes; P = 0.005) and greater intraoperative bleeding (138.3 ± 239.4ml vs. 86.6 ± 67.7ml; P = 0.002) compared to the normal BMI group. Moreover, shorter time to flatus, starting the soft diet, removing drain tube and length of stay (all P < 0.05) were observed in the high BMI patients. However, there was no significant difference in relapse-free survival or overall survival between the two groups. Conclusion Patients with high BMI was associated with longer operation time and greater amount of intraoperative bleeding but had faster recovery as compared to those with normal BMI. Also, LG can be considered as safe with no significant difference in terms of short- and long-term outcomes on the peri- and post-operative outcomes between the two BMI groups of patients. Nevertheless, these surgeries for high BMI patients should be performed by experienced surgeons.
Splenic enlargement induced by preoperative chemotherapy is a useful indicator for predicting liver regeneration after resection for colorectal liver metastases
Authors: Konishi Takanori , Yoshidome Hiroyuki , Shimizu Hiroaki , Yoshitomi Hideyuki , Furukawa Katsunori , Takayashiki Tsukasa , Kuboki Satoshi , Takano Shigetsugu , Miyazaki Masaru , Ohtsuka Masayuki 
Published: February 2020

Abstract
Background: Conversion chemotherapy may downsize unresectable colorectal liver metastases (CRLMs), but may cause liver injury and splenic enlargement. The effect of preoperative chemotherapy on liver regeneration after liver resection remains undetermined. The aim of this study was to examine whether splenic enlargement induced by preoperative chemotherapy is an indicator to identify high-risk patients for impaired liver regeneration and liver dysfunction after resection.
Methods: We retrospectively reviewed 118 Japanese patients with CRLMs. Fifty one patients had conversion chemotherapy. The other 67 patients underwent upfront liver resection. We clarified effects of conversion chemotherapy on splenic volume, liver function, and postoperative liver regeneration. Perioperative outcome was also analyzed.
Results: A ratio of the splenic volume before and after chemotherapy (SP index) in the oxaliplatin-based chemotherapy group was significantly greater than other chemotherapy groups after 9 or more chemotherapy cycles. Patients whose SP index was 1.2 or more had significantly higher indocyanine green retention rate at 15 min (ICG-R15) than patients without chemotherapy. Analyses of covariance showed liver regeneration rate after resection was decreased in patients whose SP index was 1.2 or more. The incidence of postoperative liver dysfunction in patients whose SP index was 1.2 or more was significantly greater than patients without chemotherapy. Multivariate analysis showed SP index was a significant predictive factor of impaired liver regeneration.
Conclusions: Splenic enlargement induced by preoperative chemotherapy was a useful indicator for impaired liver regeneration after resection and a decision-making tool of treatment strategy for unresectable CRLMs.
Probing the beam-induced heating effect inside a transmission electron microscope by nanoparticle labels
Authors: Zhang Lei , He Longbing , Yang Yufeng , Hong Hua , Tang Luping , Sun Litao 
Published: February 2020

Abstract
Beam-induced heating effect on nanoscale samples is a crucial question as it strongly influences the interpretation of observed unusual behaviors. This question is currently under debate without a convincing conclusion. Here, using silver nitride (Ag 3 N) nanoparticles as temperature labels, we perform an investigation on this heating effect inside a transmission electron microscope (TEM) under normal imaging conditions. Combined with experimental measurements and semi-quantitative calculations, a temperature increase of more than 100 K is estimated and confirmed in the graphite carbon nitride (g-C 3 N 4 ) films. Strong temperature gradients are found to exist in the single-end fixed g-C 3 N 4 films. The influencing factors of heat accumulation are also investigated and discussed. Findings in this paper may shed some light on the understanding of the abnormal behaviors of nano-objects observed inside TEM.
New recognition of hepatic perivascular epithelioid cell tumours (PEComa): a retrospective analysis of 35 cases
Authors: Yang Xiao , Wang Qing Yuan , Zhou Xiao , Zhou Haoming , Jia Wen Bo , Hu Chun Yang , Chu Jian , Kong Lian Bao 
Published: February 2020

Abstract
Purpose Our primary objective was to investigate the clinical features, diagnosis, treatment and prognosis of hepatic perivascular epithelioid cell tumours (PEComa).Patients and Methods Thirty-five cases of pathologically proven hepatic PEComa that were treated in the Department of Hepatobiliary Center of the First Affiliated Hospital of Nanjing Medical University from January 2008 to February 2019 were retrospectively analysed, and the literature was reviewed.Results Twenty-nine females and 6 males were included in this study. The mean age of these patients was 48.0 years (range, 21-75 years). Thirteen patients complained of upper abdominal pain and discomfort, but the tumours in the other patients were identified by performing an imaging examination. Hepatic PEComas tended to occur in the right lobe of the liver (20 cases in the right lobe, 13 in the left lobe and 2 in the caudate lobe). Two cases were characterized by multiple tumours, and the remaining cases were single lesions (range, 1.2-12 cm). Only 8 cases were correctly diagnosed by the preoperative imaging examination, and the correct diagnosis rate was only 22.9%. The postoperative immunohistochemistry analysis showed that hepatic PEComas are positive for human melanoma black 45 (HMB-45), Melan-A and smooth muscle actin (SMA), with the exception of 1 case that was negative for Melan-A. All patients undergoing an operation accepted regular follow-up, and the average time was 66.5 months (range, 3-132 months). Two patients who experienced tumour recurrence and 1 patient who died due to cardiovascular disease, but the remaining patients showed no evidence of tumour recurrence or metastasis during the follow-up period.Conclusions Hepatic PEComa is a rare type of tumour that mainly occurs in young and middle-aged women. The lack of clinical manifestations and imaging findings increases the difficulty of determining a preoperative diagnosis, which mainly depends on the pathological examinations. Surgery is currently the only effective treatment, and long-term clinical follow-up is necessary due to the aggressive behaviour and relapse of hepatic PEComa in some cases.