bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multidisciplinary Approach Improves Eradication Rate and Safety in Refractory Helicobacter pylori Infection
Authors: Dai Na , Zhao Yu-Qin , Wu Wen-Juan , Shen Zheng-Lin , Xu Yan-Hua , Wu Xiao-Yang , Zhang Gui-Zhen , Wang Lan , Wang Qing-Hua 
Published: December 2024

INTRODUCTION:

Helicobacter pylori (HP) infection is prevalent worldwide and contributes to various gastrointestinal diseases. Eradication therapy is crucial in managing HP infection, but antibiotic resistance has led to refractory cases, complicating treatment outcomes and increasing the risk of adverse events. This study aimed to evaluate the effectiveness of a multidisciplinary approach, termed HP Multidisciplinary Team (MDT) Clinic, in improving eradication rates and safety in patients with refractory HP infection.

METHODS:
Between November 2020 and November 2023, 153 patients with refractory HP infection were included, with 51 patients in the non–HP-MDT group and 102 patients in the HP-MDT group. The HP-MDT clinic provided personalized treatment plans, patient education, and follow-up. Genetic testing was conducted in selected cases to assess resistance patterns.

RESULTS:
Patients attending the HP-MDT clinic showed significantly higher eradication rates compared with those in the non–HP-MDT group (80.39% vs 50.98%, P < 0.001). Logistic regression analysis confirmed that HP-MDT clinic attendance was independently associated with higher eradication rates (odds ratio: 4.43, 95% CI: 2.02 to 9.71, P < 0.001). Genetic testing revealed high rates of antibiotic resistance, particularly to clarithromycin (10/11, 90.91%) and metronidazole (11/11, 100%). Despite resistance, the HP-MDT approach achieved a high eradication rate of 92.31%. Adverse drug reactions occurred in 12.75% of patients in the HP-MDT group, predominantly mild gastrointestinal symptoms.

DISCUSSION:
The HP-MDT clinic, integrating medical, pharmaceutical, and nursing expertise, significantly improved eradication rates and safety in patients with refractory HP infection. Personalized treatment plans, patient education, and genetic testing contributed to successful outcomes with minimal adverse events.
Inter-annual variations of summertime plankton communities in Sishili Bay, Northern Yellow Sea, China
Authors: Jiang Huichao , Liu Ning , Ma Yuanqing , Yang Guohua , Qin Huawei , He Jianlong , Cheng Ling , Zhang Juan , Tao Huimin , Gu Weili , Dong Xiaoxiao , Li Zhilin 
Published: December 2024

Abstract
With an intensive increase in anthropogenic activities, plankton communities in coastal areas show deterioration, such as shifts from diatom-dominated to more dinoflagellates and cyanobacteria, and increasing gelatinous zooplankton. To further understand the dynamic changes in plankton communities under anthropogenic activities in coastal areas, a multi-annual survey comprising nine cruises in summer during 2012–2020 was conducted in Sishili Bay, China. The results showed that the phytoplankton community in Sishili Bay was mainly dominated by diatoms, with an abundance of 94.86%; copepods were the dominant taxa in the zooplankton community, accounting for 64.57% of the total abundance, followed by zooplankton larvae (24.74%) including bivalvia, copepoda nauplius, ophiopluteus, etc, whereas other taxonomic groups, such as cladocerans, tunicates, chaetoganatha, cnidarians, protozoa, mysidacea, and ctenophores only accounted for 10.69% of the total abundance. Noticeable changes were observed in the plankton community, accompanied by some signals of community deterioration: dinoflagellates presented an increasing trend compared with that in diatoms; zooplankton larvae and gelatinous organisms also displayed apparent increasing trends. Restriction of dissolved inorganic phosphorus (DIP) combined with an increase in total phosphorus was conducive to a proportional increase in dinoflagellates. Overall, these results suggest that sea reclamation and marine cage aquaculture have promoted an increase in gelatinous organisms. The observed juvenilization of zooplankton might be driven by a trophic cascade effect caused by an increase in carnivorous zooplankton. Overall, the present study highlights the importance of anthropogenic activities affecting plankton inter-annual changes and suggests that the nutrient structure and control of anthropogenic activities should be investigated in detail for the protection and restoration of marine ecological environments.
Possible lessons on rapid assessment of fish kills in cages in Lake Victoria, Kenya for informed decision making
Authors: Aura Christopher Mulanda , Ntiba Micheni Japhet 
Published: December 2024

Abstract
Cage aquaculture is quickly expanding in the African Great Lakes Region, with the potential of boosting fish output and acting as a source of food security, poverty reduction, job and wealth creation. However, the proliferation of fish cages in Lake Victoria has come along with sporadic fish kills especially in the shallow zones of the lake in specifically the months of September to November each year and whose documentation is key for future references in case such occurrences reoccur. This paper indicates and discusses results from a rapid assessment of recent fish kills in the years 2021 and 2022 and sheds some light on the possible causes of the fish kills using standard methods and proposes mitigation measures moving forward. Low dissolved oxygen levels (≤ 4.0 mg L-1) instigated by increased eutrophication and upwelling are noted as the main causes of the fish kills. The application of good aquaculture practices for fish cage culture husbandry, application of guidelines as well as fast-tracking and enforcement of regulations will promote sustainable cage farming in such lacustrine systems.
Effect of malachite green on post-exposure filtration rate of Blood Clam Barbartia virescens (Reeve 1844)
Authors: Mandario Mary Anne E. , Añasco Nathaniel C. , Koyama Jiro , Balinas Vicente T. 
Published: December 2024

Abstract
The aim of this study was to investigate the effect of malachite green on the post-exposure filtration rate of Blood Clam, Barbatia virescens. Blood Clams were collected from the rocky coast and acclimated to laboratory conditions for 18 days. Bioassays were conducted wherein Blood Clams were exposed for 24 h to a clean medium (no malachite green), 0.06 mg l-1 malachite green, 0.32 mg l-1 malachite green, 5.06 mg l-1 malachite green, and then to the same concentrations for 48 h. Filtration rate in all concentrations and malachite green-exposure durations were determined at 0.5, 1, 2, 3, 4, and 6 h. Blood Clams exposed for 24 h and 48 h to 0.32 and 5.06 mg l-1 had significantly lower filtration rates than the control (p &lt;0.05). Similarly, those exposed to 0.06 mg l-1 for 48 h showed significant reduction in their filtration rates. The lower rate was associated with longer exposure to malachite green. In addition, Blood Clams exposed for 48 h were not able to improve their filtration rate, although they were transferred to a clean medium for 6 h. The green colouration on Blood Clams’ muscles was also not eliminated. These findings suggest the ecological risk of malachite green to bivalves and its implications to the health of sessile coastal organisms.
Sonication Enhancement of Capsaicin Formation in Callus of Chili Pepper, Capsicum annuum L.
Authors: Masyab Hikmat M. 
Published: December 2024

The current study investigates the induction of callus from leaf explants of chili pepper Capsicum annuum L. coupled with the isolation of capsaicin from alcoholic extracts. To determine which isolated alkaloid has a positive reaction, the DragenDroff test is used. Alkaloid is identified using conventional diagnostic techniques, such as measuring the absorbance values of the isolated alkaloid with an ultraviolet spectrophotometer, the alkaloid is identified. The results show a complete identity among them, and with control. Thin layer chromatography data showed a 0.8 cm distance between one location from each tested sample with the same rate, which is 0.8 cm from the control’s rate flow value. The chemical structure of studied samples is subsequently determined using nuclear magnetic resonance, which reveals similarities between the isolated alkaloid’s structure and standard capsaicin. A quantitative analysis of the isolated alkaloids revealed variations in the amounts for generated explants relative to other explants. This study shows that fruits are the most effective source of alkaloids. It’s interesting to note that the composition of the explant and the sonicated callus are identical. Since capsaicin discovery, it is used as a homeopathic remedy to treat burning pain using the concept of “treating like with like” or counterirritant, relieve minor pain associated with rheumatoid arthritis or muscle sprains and strains and due to large consumption of this fruit recently, the current study done to find out the structure and quantity.
Correlation Between Lipoprotein(a) and Prognosis for Coronary Artery Disease in Patients Undergoing Percutaneous Coronary Intervention
Authors: ShaMa Azhi , Ma Chunlan , Huang Yingying , Hu Jingyue , Xu Chunmei , Li Zhuxin , Wang Jing , Zeng Chunyu 
Published: December 2024

Abstract

Background:
Elevated lipoprotein(a) (Lp[a]) is a risk factor for first atherosclerotic thrombosis events, but the role of elevated Lp(a) in secondary prevention is controversial. This study aimed to retrospectively investigate the influence of elevated Lp(a) levels on the prognosis of patients with coronary artery disease.

Methods:
The team collected and compared clinical information of patients hospitalized during percutaneous coronary intervention (PCI). This study used a multivariate logistic regression model to evaluate the relationships between Lp(a) levels, cardiovascular risk factors, and the prognosis of coronary artery disease in patients undergoing PCI.

Results:
There were no statistically significant differences between patients grouped according to Lp(a) level in terms of sex; age; body mass index and obesity; hyperuricemia; smoking; cardiac insufficiency; acute myocardial infarction; multivessel lesion; in-stent restenosis; secondary PCI; apolipoprotein AI level; incidence of high total cholesterol or high low-density lipoprotein cholesterol; or family history of hypertension, diabetes, or coronary artery disease. The average Lp(a) concentration did not statistically significantly decrease after 1 year of statin treatment after PCI. One year after patients began statins, there were no significant differences between Lp(a) groups in the incidence of high triglycerides (P = .13), high total cholesterol (P = .52), or high low-density lipoprotein cholesterol (P = .051). Multivariate logistic regression analysis indicated that diabetes (P = .02) was associated with in-stent restenosis, whereas diabetes (P = .02) and multivessel lesions (P < .001) were associated with secondary PCI in patients who underwent coronary angiography 1 year after PCI. Compared with normal Lp(a) levels, high Lp(a) levels did not significantly increase the incidence of in-stent restenosis or secondary PCI in patients who underwent coronary angiography 1 year after PCI.

Conclusion:
Sustained high concentrations of Lp(a) did not significantly increase the incidence of in-stent restenosis or secondary PCI in patients who underwent coronary angiography 1 year after PCI.
Concept of a load reducing knee-orthosis
Authors: Abdulrazeq Abdallah , Al-Hazba Ahmed , Pöschel Till , Thomas Hanna , Boese Axel 
Published: December 2024

Abstract
Joint diseases are one of the significant challenges that come with age. The pain that these diseases cause can affect the quality of life of the patient, especially if the disease is causing aches in a high-load-bearing joint like the knee. Most patients these days choose to undergo total joint arthroplasty. However, some patients cannot do the surgery for different reasons or choose to delay it as late as possible. Their only option is to use a walking stick with the associated restrictions in terms of quality of life and incorrect physical strain. To help those patients and reduce their pain, this work aimed to create a concept that reduces the load acting on the knee and lower leg. Alleviating the load on the knee joint has been identified as a crucial factor in reducing pain associated with various knee conditions. To achieve this, the load should be partially transferred from the upper leg to the ground. Following the primary design process stages, a first demonstrator was built and tested. The results of the tests indicated that the device could reduce 30 % of the load exerted on the knee during the first phase of walking. Moreover, it takes around 27 seconds to fasten the device to the user's leg. The overall conclusion is that the first demonstrator proved the validity of the main concept, although there is room for improvement.
Multi-view surgical phase recognition during laparoscopic cholecystectomy
Authors: Bajraktari Flakë , Pott Peter P. 
Published: December 2024

Abstract
In the realm of laparoscopic procedures, intelligent context-aware assistance systems hold promise for enhancing surgical workflows and patient safety. This study employs a multi-view approach to recognize surgical phases, combining data from a laparoscopic camera and an in-room camera simultaneously. The study aimed to improve phase recognition accuracy using a Transformer-based model with late sensor fusion, which yielded mixed results. The data poses significant challenges, as self-recorded videos are insufficient for extracting relevant information, necessitating real-world data. Additionally, the overall model needs refinement, as certain components degrade performance with poor data. This research highlights the complexities and opportunities in integrating multiview data for surgical phase recognition, emphasizing the importance of diverse data collection strategies and model architectures for real-world surgical settings.
Enhancing No Reference Laparoscopic Video Quality Assessment with Evolutionary ANFIS
Authors: Biswas Sria , Palanisamy Rohini 
Published: December 2024

Abstract
Distortions in laparoscopic videos affect surgeon visibility and surgical precision, underscoring the need for sustained high video quality. This study presents a real-time laparoscopic video quality assessment algorithm independent of reference content availability. Statistical parameters derived from luminance, local binary pattern and motion-vector maps of video frames are observed to effectively discern distortion types and severities. These parameters are used to train an evolutionary adaptive neuro-fuzzy inference system (ANFIS) end-to-end with subjective score labels. Training and validation loss curves saturate at the 85th epoch, demonstrating the model’s efficient data fitting capability. Performance comparison with other state-of-the-art methods reveals superior results, with high correlation scores of 0.9989 and 0.9446 for experts and 0.9956 and 0.9847 for non-experts, alongside low root mean square errors of 0.0828 and 0.1685 for expert and non-experts, respectively. The model accurately replicates the expert and non-expert perceptual opinions, encouraging future research in stereoscopic, augmented, and virtual reality data.
Using a confined space to boost the driving amplitude of pulsating bubbles to facilitate jetting
Authors: Carlson Craig S. , Anderton Nicole , Aharonson Vered , Otake Naoyuki , Xinyue Hu , Yamasaku Momoka , Hashimoto Mamoru , Kudo Nobuki , Postema Michiel 
Published: December 2024

Abstract
A bubble collapsing near an interface may result in the formation of a liquid jet protruding from the distal bubble side, through the bubble, towards the interface. Ultrasound assisted jetting has been observed when subjecting, by approximation, infinite fluids to acoustic amplitudes above the inertial cavitation threshold, limiting the possibility of ultrasoundguided, bubble-assisted drug or gene delivery. However, the vascular system can be regarded as a finite fluid. The purpose of this study was to investigate the feasibility of lowamplitude jetting for fluid containing biocompatible cavitation nuclei, by placing the region of interest in a confined space to ensure a standing wave field. Droplets of QuantisonTMultrasound contrast agent were pipetted into a Perspex cylindrical compartment of 8-mm diameter and 2-mm height, which was part of an imaging system. The contrast agent was subjected to 3-cycle ultrasound pulses with a centre frequency of 1MHz whilst being observed at a frame rate of ten million frames per second. Jetting was observed to occur with microbubbles nucleated from the contrast agent in an acoustic regime whose free-field mechanical index was 0.6. Empirical curve matching showed a pulse amplification by a factor of six owing to the chosen geometry. Visible jet lengths of twice the bubble radius on the verge of collapse were measured. Owing to the confined space, the local acoustic amplitude was amplified to surpass the cavitation threshold. This finding is of interest for medical ultrasonic applications where the local environment comprises reflectors.
Non-invasive and continuous monitoring of 3D stem cell culture in a bioreactor
Authors: Carrillo Mario , Altmaier Saskia , Meiser Ina , Ihmig Frank R. 
Published: December 2024

Abstract
The development and discovery of new drugs and therapy products in regenerative medicine are carried out through multiple stages which involve several strict quality protocols. The use of cell-based model systems is the most relevant alternative to deviate from animal testing. However, the underlying biomanufacturing process in a 3D environment can be prone to failures or unexpected behaviors such as cell growth anomalies or inconsistencies in cell aggregation, which can seriously affect the quality of the result. Therefore, it is necessary to establish a non-invasive and continuous monitoring mechanism that minimizes contamination risks, allows taking early decisions and enables large-scale production in the long term. The results of our embedded machine learning approach show that it is feasible to train machine learning models that can operate on a resourcelimited embedded board with acceptable prediction accuracy for the estimation of the average size of growing stem cell spheroids. Further experiments are needed to investigate the full information potential of the recorded process data.
Development and Validation of a Patient Model for Simulating Anaesthetic Uptake
Authors: Demgensky Clara , Hennigs Carlotta , Kater Andreas , Bargstädt Björn , Rostalski Philipp 
Published: December 2024

Abstract
Mathematical patient models play a profound role in the managing and understanding of anaesthesia. This article proposes a patient model for simulating anaesthetic uptake, i.e. the storing of anaesthetic gases in the human body, thus extending a well known four compartment model from literature. Real time data is used for the simulation, from which the sevoflurane concentration is extracted. The exhaled concentrations from the model and the data are compared. A literature model is extended with ratios of compartmental perfusion, the introduction of coefficients representing diffusion and the change of the solubility coefficient. The extended and the literature model are applied to five training data sets, with prior optimization of the parameters that have the most impact. Afterwards, both models are validated on five additional data sets. The results of the extended model are mostly better than the results of the literature model. Therefore, the extensions improve the model for the used data, but need to be validated with a larger amount of data.
Impact of the European proposal to restrict PFAS on modern medical technology and treatment options
Authors: Derad Lukas , Thaler Melanie , Wiktor Kevin , Bregulla Rainer , Bader Christian 
Published: December 2024

Abstract
Functionality of state-of-the-art medical devices often depends on high-end materials. Today, a large spectrum of medical devices like heart valves, vascular grafts, sutures or endoscopic devices consist of or incorporate fluoropolymers like polytetrafluoroethylene (PTFE). Fluoropolymers offer unique mechanical, electrical and chemical properties. Based on their chemical constitution, fluoropolymers are assigned to the group of per- and polyfluorinated substances (PFAS). The aim of the current restriction proposal within Europe (EU) is to limit and/or fully ban the persistent PFAS substances known as forever chemicals. The restriction proposal concerns all PFAS substances beyond further subdividing and evaluating their hazardous potential and with just short-term derogations depending on the application. The consequences of the impending restriction proposal on PFAS is shown from a medical device industry viewpoint. Literature data on annual material consumption and supply chain are collected and evaluated, especially pointing to future problems assuming an entry into force of the pending restriction proposal. Furthermore, the short derogation times are contextualized with current timelines of Medical Device Regulation (MDR) approval processes to highlight the impact on product availability assuming a PFAS ban. Selected examples of affected products illustrate, how patient treatment options are limited by the PFAS restriction. It can be clearly shown that the PFAS restriction will critically affect the medical device sector through collapsed supply chain and insufficient derogation times for product approvals, thus limiting the availability of medical products and setting back the gold standards in medical treatment.
Integration Models for SDC-capable Medical Devices into an Existing OR Network
Authors: Deutschle Jennifer , Beyersdorffer Patrick , Junger Denise , Tangemann Michael , Seitz Björn , Burgert Oliver 
Published: December 2024

Abstract
The interconnection of medical devices in an operating room (OR) represents a major step in optimizing clinical processes and increasing the quality of treatment. The IEEE 11073 Service-oriented Device Connectivity (SDC) standard family constitutes the foundation for manufacturerindependent information exchange and remote control of medical devices. However, integrating new SDC-capable devices into an existing OR network poses a major challenge for medical device manufacturers. Thus, suitable integration models are required. This work focuses on the definition of three possible integration models and their comparison according to architectural design patterns. Thereby, the use case of integrating a high-frequency (HF) surgical device to interconnect with existing SDC-capable devices is pursued. One of the models, which focuses on high expandability and low coupling, was successfully applied to interconnect an HF surgical device with an OR light in the research OR of Reutlingen University. The results indicate transferability to other integration scenarios and are intended to further promote manufacturer-independent integrated ORs.
Pressure Modulation Improves Locomotion of an Expanding Robot for Colonoscopy
Authors: Dinkel Johanna , Weinmann Denise , Pott Peter P. , Schäfer Max B. 
Published: December 2024

Abstract
Colonoscopy plays a pivotal role in early colorectal disease detection. It is hindered by procedural difficulties such as friction between colonoscope and colon wall as well as maneuverability issues. Expanding robots offer a promising alternative, aiming for a reduced risk of tissue damage and reduced forces between colononscope and tissue. In this paper, the usage of expanding locomotion for colonoscopy is investigated to address technical challenges. Preliminary tests on a custom-designed test rig demonstrate the potential of intermitted advancement and retraction modes to overcome challenges such as the difference in pathlength of robot body and working channel as well as the typical buckling during retraction of expanding robots. Future research will focus on refining control systems based on sensor feedback and evaluating additional parameters for clinical application.