bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID‐19 in cancer patients on active systemic therapy – Outcomes from LMIC scenario with an emphasis on need for active treatment
Authors: Ramaswamy Anant , Nayak Lingaraj , Roy Moulik Nirmalya , Sengar Manju , Chinnaswamy Girish , Jobanputra Kunal , Shah Minit J. , Kapoor Akhil , Joshi Amit , Kumar Amit , Gokarn Anant , Bonda Avinash , Cheriyalinkal Parambil Badira , Prasad Maya , Bagal Bhausaheb , Dhamne Chetan , Narula Gaurav , Jain Hasmukh , Ghosh Jaya , Thorat Jayashree , Bajpai Jyoti , Menon Nandini , Khattry Navin , Bhargava Prabhat , Punatar Sachin , Gulia Seema , Banavali Shripad , Gupta Sudeep , Srinivas Sujay , Rath Sushmita , Vora Tushar , Noronha Vanita , Patil Vijay M. , Ostwal Vikas , Prabhash Kumar 
Published: October 2020

AbstractBackgroundThere is limited data on outcomes in cancer patients with coronavirus disease 2019 (COVID‐19) from lower middle‐income countries (LMICs).Patients and MethodsThis was an observational study, conducted between 12 April and 10 June 2020 at Tata Memorial centre, Mumbai, in cancer patients undergoing systemic therapy with laboratory confirmed COVID‐19. The objectives were to evaluate cumulative 30‐day all‐cause mortality, COVID‐19 attributable mortality, factors predicting mortality, and time to viral negativity after initial diagnosis.ResultsOf the 24 660 footfalls and 7043 patients evaluated, 230 patients on active systemic therapy with a median age of 42 (1‐75) years were included. COVID‐19 infection severity, as per WHO criteria, was mild, moderate, and severe in 195 (85%), 11 (5%), and 24 (11%) patients, respectively. Twenty‐three patients (10%) expired during follow‐up, with COVID‐19 attributable mortality seen in 15 patients (6.5%). There were no mortalities in the pediatric cohort of 31 (14%) patients. Advanced stage cancer being treated with palliative intent vs others [30‐day mortality 24%% vs 5%, odds ratio (OR) 5.6, 95% CI 2.28‐13.78, P < .001], uncontrolled cancer status vs controlled cancer (30‐day mortality37.5%% vs 4%%, OR 14, 95% CI 4.46‐44.16, P < .001) and severe COVID‐19 vs mild COVID‐19 (30‐day mortality 71% vs 3%, OR 92.29, 95% CI 26.43‐322.21, P < .001) were significantly associated with mortality. The median time to SARS‐CoV‐2 RT‐PCR negativity was 17 days [interquartile range (IQR)17‐28) in the cohort.ConclusionsThe mortality rates in cancer patients with COVID‐19 who are receiving systemic anti‐cancer therapy in LMICSs are marginally higher than that reported in unselected COVID‐19 cohorts with prolonged time to viral negativity in a substantial number of patients. The pediatric cancer patients tended to have favorable outcomes.
Higher miR‐543 levels correlate with lower STK31 expression and longer pancreatic cancer survival
Authors: Yuan Weizhong , Gao Hao , Wang Guangfu , Miao Yi , Jiang Kuirong , Zhang Kai , Wu Junli 
Published: October 2020

AbstractPancreatic cancer (PC) is one of the most malignant gastrointestinal tumors and the 5‐year survival is only 9%. The expression of miRNAs in serum has been proved to be related to tumorigenesis and development of cancers. The miRNA targets and gene targets were predicted in microRNA.org, miRDB, TargetScan, and RNAInter. The expression data of STK31 (Serine/Threonine Kinase 31) and miRNAs generated from PC samples was from TCGA and the relationship of expression of STK31 and miR‐543 was confirmed in PC samples from our center. Double luciferase reporter gene assay was used to demonstrate the direct binding between miR‐543 and STK31. The effect of expression level of miRNAs on survival time was assessed by Kaplan–Meier curves. The Go Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of miR‐543‐related genes were performed. The results showed that miR‐543 had a statistically significant correlation with the expression of STK31 and contained the direct binding site with STK31. The expression level of miR‐543 may affect the survival of PC. The results of GO and KEGG pathway analysis showed that miR‐543 might play a key role in Insulin signaling pathway. MiR‐543 could be combined with STK31 and affect the expression of STK31. The expression of miR‐543 could also predict the survival of patients with PC, which suggested that miR‐543 might play an important role in PC. The GO and KEGG pathway analysis also displayed that miR‐543 was involved in several other pathways of pancreas.
Pamiparib dose escalation in Chinese patients with non‐mucinous high‐grade ovarian cancer or advanced triple‐negative breast cancer
Authors: Xu Binghe , Yin Yongmei , Dong Mei , Song Yan , Li Wei , Huang Xiang , Wang Tongshan , He Jing , Mu Xiyan , Li Li , Mu Song , Zhang Wa , Li Miao 
Published: October 2020

AbstractBackgroundThe recommended phase 2 dose (RP2D) of pamiparib, an investigational PARP1/2 inhibitor, was established as 60 mg twice daily (BID) in a first‐in‐human (FIH) study (NCT02361723).MethodsChinese patients with advanced non‐mucinous high‐grade ovarian cancer (HGOC) or triple‐negative breast cancer (TNBC) whose disease either progressed despite standard therapy, or for which there is no standard therapy were enrolled in the dose‐escalation (DE) portion of a phase 1/2 study (NCT03333915). The primary endpoint was safety/tolerability; secondary objectives were pharmacokinetics and antitumor activity. BRCA1/2 mutation status was retrospectively evaluated.ResultsNine HGOC and six TNBC patients (N = 15; n = 4, 20 mg; n = 4, 40 mg; n = 7, 60 mg) were enrolled; as of 30 September 2019, one HGOC patient remained on treatment. Seven patients (n = 5, HGOC; n = 2, TNBC) had germline BRCA1/2 mutation (gBRCAmut); all HGOC patients were resistant/refractory to platinum. Asthenia and nausea (n = 12 each) were the most common treatment‐related adverse events (TRAEs). Decreased hemoglobin was the most common grade 3 TRAE (n = 3); no grade ≥4 AEs were observed. No dose‐limiting toxicities (DLTs) were reported. Pamiparib plasma exposure was similar to exposure observed in the FIH study after a single‐dose administration, albeit slightly higher at steady state. Among 13 RECIST‐evaluable patients, two with HGOC (gBRCAmut, n = 1) achieved a confirmed partial response and six with HGOC (gBRCAmut, n = 4) achieved stable disease; all TNBC RECIST‐evaluable patients (n = 5) reported progressive disease.ConclusionsPamiparib was generally well tolerated in Chinese patients, with durable responses observed in patients with HGOC. Based on these results, pamiparib 60 mg BID was confirmed as the RP2D.
Displacement of the third molar bud to the sublingual space during open reduction and internal fixation of mandibular angle fracture: A case report
Authors: Sharifi Reza , Kamaliehakim Lotfollah , Matloubi Narges 
Published: October 2020

AbstractThis case could remind surgeons to consider the possibility of displacement of the impacted third molar in the fractured line to adjacent spaces, during open reduction and internal fixation of mandibular angle fracture.
Giant juvenile fibroadenoma in an adolescent female: A case report
Authors: Baral Suman , Gyawali Milan , Thapa Neeraj , Chhetri Raj Kumar , Dahal Prahar 
Published: October 2020

AbstractGiant juvenile fibroadenoma in adolescents should be dealt with utmost caution as this may be associated with anxiety, fear, and emotional factors. The treatment should aim for preserving the normal contour of the breast along with appealing scar.
Self‐Assembly/Sacrificial Synthesis of Highly Capacitive Hierarchical Porous Carbon from Longan Pulp Biomass
Authors: Wang Jie , Ma Chuanli , Su Linghao , Gong Liangyu , Dong Dongqi , Wu Zexing 
Published: October 2020

AbstractExploration of efficient strategies for highly capacitive electrodes is of great significance for the development of advanced energy devices. Herein, we propose a novel method for the preparation of a hierarchical porous carbon material derived from longan pulp biomass for application in supercapacitors. First, a precursor of the two‐dimensional graphitized carbon with uniform carbon spheres is self‐assembled via a hydrothermal method with a post‐calcination process. After that, the longan pulp hierarchical porous carbon with inner pores is achieved through an embedding method with a mixture of precursor, KOH and KCl at high‐pressure and appropriate annealing temperature by self‐sacrificial means. The rich mesopores inside the sheet of LHPC‐3 demonstrate a more conducive strategy to create holes inside the materials, which is beneficial for electrical double‐layer capacitance. As a result, the LHPC‐3 is characterized with a high specific surface area of 1678 m2 g−1 and an abundance of meso‐/micropores, which facilitate the electrolyte penetration and mass transfer rates. Accordingly, LHPC‐3 exhibits an excellent specific capacitance of 380 and 153 F g−1 at 0.5 A g−1 in three‐electrode and symmetric supercapacitor systems, respectively. The new synthesis strategy is more conducive to the internal pore formation of carbon materials and has the potential to be widely applied to the synthesis of other electrochemical materials.
The links among interpersonal conflict, personal and contextual resources, and creative behaviour
Authors: De Clercq Dirk , Belausteguigoitia Imanol 
Published: October 2020

AbstractThis study examines how employees' exposure to interpersonal conflict might reduce their creative behaviour, with a particular focus on how this negative connection might be mitigated by their access to pertinent personal and contextual resources. Using data from employees who work in the construction sector, the empirical findings reveal that interpersonal conflict thwarts creativity, but this effect is weaker when employees can more easily control their emotions, have clear job descriptions, and are satisfied with how their employer communicates with them. Empathy exhibits a weak effect. This study accordingly reveals different means through which organizations can overcome the challenge that arises when emotion‐based conflicts steer employees away from creativity.
Orcokinin in the central complex of the locust Schistocerca gregaria: Identification of immunostained neurons and colocalization with other neuroactive substances
Authors: Homberg Uwe , Hensgen Ronja , Rieber Evelyn , Seyfarth Jutta , Kern Martina , Dippel Stefan , Dircksen Heinrich , Spänig Lisa , Kina Yelda Pakize 
Published: October 2020

AbstractThe central complex is a group of highly interconnected neuropils in the insect brain. It is involved in the control of spatial orientation, based on external compass cues and various internal needs. The functional and neurochemical organization of the central complex has been studied in detail in the desert locust Schistocerca gregaria. In addition to classical neurotransmitters, immunocytochemistry has provided evidence for a major contribution of neuropeptides to neural signaling within the central complex. To complement these data, we have identified all orcokinin‐immunoreactive neurons in the locust central complex and associated brain areas. About 50 bilateral pairs of neurons innervating all substructures of the central complex exhibit orcokinin immunoreactivity. Among these were about 20 columnar neurons, 33 bilateral pairs of tangential neurons of the central body, and seven pairs of tangential neurons of the protocerebral bridge. In silico transcript analysis suggests the presence of eight different orcokinin‐A type peptides in the desert locust. Double label experiments showed that all orcokinin‐immunostained tangential neurons of the lateral accessory lobe cluster were also immunoreactive for GABA and the GABA‐synthesizing enzyme glutamic acid decarboxylase. Two types of tangential neurons of the upper division of the central body were, furthermore, also labeled with an antiserum against Dip‐allatostatin I. No colocalization was found with serotonin immunostaining. The data provide additional insights into the neurochemical organization of the locust central complex and suggest that orcokinin‐peptides of the orcokinin‐A gene act as neuroactive substances at all stages of signal processing in this brain area.
Identification of retinal ganglion cell types and brain nuclei expressing the transcription factor Brn3c/Pou4f3 using a Cre recombinase knock‐in allele
Authors: Parmhans Nadia , Fuller Anne Drury , Nguyen Eileen , Chuang Katherine , Swygart David , Wienbar Sophia Rose , Lin Tyger , Kozmik Zbynek , Dong Lijin , Schwartz Gregory William , Badea Tudor Constantin 
Published: November 2020

AbstractMembers of the POU4F/Brn3 transcription factor family have an established role in the development of retinal ganglion cell (RGCs) types, the main transducers of visual information from the mammalian eye to the brain. Our previous work using sparse random recombination of a conditional knock‐in reporter allele expressing alkaline phosphatase (AP) and intersectional genetics had identified three types of Brn3c positive (Brn3c+) RGCs. Here, we describe a novel Brn3cCre mouse allele generated by serial Dre to Cre recombination and use it to explore the expression overlap of Brn3c with Brn3a and Brn3b and the dendritic arbor morphologies and visual stimulus response properties of Brn3c+ RGC types. Furthermore, we explore brain nuclei that express Brn3c or receive input from Brn3c+ neurons. Our analysis reveals a much larger number of Brn3c+ RGCs and more diverse set of RGC types than previously reported. Most RGCs expressing Brn3c during development are still Brn3c positive in the adult, and all express Brn3a while only about half express Brn3b. Genetic Brn3c‐Brn3b intersection reveals an area of increased RGC density, extending from dorsotemporal to ventrolateral across the retina and overlapping with the mouse binocular field of view. In addition, we report a Brn3c+ RGC projection to the thalamic reticular nucleus, a visual nucleus that was not previously shown to receive retinal input. Furthermore, Brn3c+ neurons highlight a previously unknown subdivision of the deep mesencephalic nucleus. Thus, our newly generated allele provides novel biological insights into RGC type classification, brain connectivity, and cytoarchitectonic.
Job satisfaction at specialized eating disorder units in Norway
Authors: Hage Trine Wiig , Rø Øyvind 
Published: October 2020

AbstractObjectivePatients with an eating disorder are frequently referred to as a particularly challenging group to treat. As a consequence, it is important to understand how working with eating disorders affects workplace well‐being. Job satisfaction is a key indicator of workplace welfare. The aims of the current study were to (a) measure overall job satisfaction among healthcare providers working at specialized eating disorder units in Norway, and (b) to investigate possible differences in job satisfaction between professional groups and between staff working fixed versus rotating shifts.MethodThis cross‐sectional study is part of a larger study investigating work‐related well‐being at specialized eating disorder units in Norway. The total sample was composed of 186 participants from 11 specialized eating disorder units.ResultsOverall, high job satisfaction was found across all professional groups. There were significant differences between daytime and shift workers on several dimensions of job satisfaction. Medical doctors and clinical psychologists scored significantly higher than nursing staff on several aspects of job satisfaction.DiscussionThis study suggests high job satisfaction across all professional groups among healthcare providers working at specialized eating disorder units, contrary to commonly‐held beliefs that working with eating disorders is very demanding.
Asymmetric competition and floater dynamics
Authors: Noonburg Erik G. , Anderson Rindy C. 
Published: October 2020

AbstractIn territorial species, nonterritorial floaters may be critical to population dynamics. One theoretical framework, based on the assumption that floating is a strategic decision to forego reproduction, predicts that selection maintains an abundant floater population even if low‐quality territories are available. However, existing models make two critical assumptions: all individuals have equal competitive ability, and every individual in a population has access to every available territory. We assess the consequences of relaxing these assumptions in a model of asymmetric competition with a trade‐off between investment in competitiveness and reproductive success. Our results demonstrate that selection for greater competitiveness eliminates floater production unless the outcome of territorial contests has a strong stochastic component. Next, we suppose individuals can compete for territories only within a fixed neighborhood. If this constraint is sufficiently strong, our model predicts that a population will produce floaters. Finally, we show that our model makes novel predictions regarding the maintenance of trait variation and the relationship between this variation and the distribution of competitors among unequal territories.
European Society of Cardiology Working Group on Adult Congenital Heart Disease and Study Group for Adult Congenital Heart Care in Central and South Eastern European Countries consensus paper: current status, provision gaps and investment required
Authors: Brida Margarita , Šimkova Iveta , Jovović Ljiljana , Prokšelj Katja , Antonová Petra , Balint Hajnalka Olga , Gumbiene Lina , Lebid Ihor H. , Komar Monika , Kratunkov Pencho , Kovačević Preradović Tamara , Ermel Raili , Strenge Agnese , Coman Ioan Mircea , Vukomanović Vladislav , Gatzoulis Michael A. , Roos‐Hesselink Jolien W. , Diller Gerhard‐Paul 
Published: November 2020

AimsTo examine the current status of care and needs of adult congenital heart disease (ACHD) services in the Central and South Eastern European (CESEE) region.Methods and resultsWe obtained data regarding the national ACHD status for 19 CESEE countries from their ACHD representative based on an extensive survey for 2017 and/or 2018. Thirteen countries reported at least one tertiary ACHD centre with a median year of centre establishment in 2007 (interquartile range 2002–2013). ACHD centres reported a median of 2114 patients under active follow‐up with an annual cardiac catheter and surgical intervention volume of 49 and 40, respectively. The majority (90%) of catheter or surgical interventions were funded by government reimbursement schemes. However, all 19 countries had financial caps on a hospital level, leading to patient waiting lists and restrictions in the number of procedures that can be performed. The median number of ACHD specialists per country was 3. The majority of centres (75%) did not have ACHD specialist nurses. The six countries with no dedicated ACHD centres had lower Gross Domestic Product per capita compared to the remainder (P = 0.005).ConclusionThe majority of countries in CESEE now have established ACHD services with adequate infrastructure and a patient workload comparable to the rest of Europe, but important gaps still exist. ACHD care is challenged or compromised by limited financial resources, insufficient staffing levels, and reimbursement caps on essential procedures compared to Western Europe. Active advocacy and increased resources are required to address the inequalities of care across the continent.
Dexmedetomidine versus clonidine adjuvants to levobupivacaine for ultrasound‐guided transversus abdominis plane block in paediatric laparoscopic orchiopexy: Randomized, double‐blind study
Authors: Mostafa Mohamed F. , Hamed Esam , Amin Ahmed H. , Herdan Ragaa 
Published: October 2020

AbstractBackgroundLaparoscopic surgeries are associated with less postoperative pain and adverse events compared to open procedures. But, it still reduces the quality of life in children. Transversus abdominis plane (TAP) block is used to reduce pain. We hypothesized that dexmedetomidine or clonidine could improve the analgesic profile of levobupivacaine to the same extent during TAP block in children.MethodsNinety children were randomly allocated in a randomized double‐blind trial to receive bilateral TAP block with levobupivacaine plus normal saline (group B, n = 30), or dexmedetomidine (group D, n = 30) or clonidine (group C, n = 30). Primary outcome was the modified Children's Hospital of Eastern Ontario Pain Scale score. Secondary outcomes included time to initial analgesic request, number of analgesic claims, total analgesic consumption, parents' satisfaction, sedation score and complications.ResultsChildren of group D showed reduced pain scores compared to other groups. They represented the longest period of analgesia (565.00 ± 71.5 min) with p < 0.001, and fewer patients required two doses of analgesia during the first postoperative day. The cumulative amount of backup analgesia was significantly different between these groups (p = 0.026). Higher parents’ satisfaction scores were recorded in groups D and C compared to group B. Sedation among the study groups revealed significant differences (p = 0.035), but no severe complications were recorded.ConclusionsAdding dexmedetomidine to levobupivacaine can extend the time of analgesia and reduce the use of postoperative backup analgesics with minimal sedation effects when used in TAP block in paediatrics undergoing laparoscopic orchiopexy. Clonidine can be used as an alternative adjuvant to local anaesthetics with good postoperative analgesic profiles.SignificanceClonidine can alternate dexmedetomidine during TAP block with local anesthetics for pediatrics laparoscopies. Both can lead to better postoperative analgesic profiles. Clonidine may be preferred, especially in our developing regions, because of its easy availability and lower cost than that of dexmedetomidine.
Faces of clinical pain: Inter‐individual facial activity patterns in shoulder pain patients
Authors: Kunz Miriam , Prkachin Kenneth , Solomon Patricia E. , Lautenbacher Stefan 
Published: November 2020

AbstractBackgroundFacial activity during pain is composed of varying combinations of a few elementary facial responses (so‐called Action Units). A previous study of experimental pain showed that these varying combinations can be clustered into distinct facial activity patterns of pain. In the present study, we examined whether comparable facial activity patterns can also be identified among people suffering from clinical pain; namely, shoulder pain.MethodsFacial expressions of patients suffering from shoulder pain (N = 126) were recorded while twice undergoing a battery of passive range‐of‐motion tests to their affected limbs (UNBC‐McMaster Shoulder Pain Expression Archive Database), which elicited peaks of acute pain. Facial expressions were analysed using the Facial Action Coding System to extract facial Action Units (AUs). Hierarchical cluster analyses were used to look for characteristic combinations of these AUs.ResultsCluster analyses revealed four distinct activity patterns during painful movements. Each cluster was composed of different combinations of pain‐indicative AUs, with one AU common to all clusters, namely, “narrowed eyes”. Besides these four clusters, there was a “stoic” pattern, characterized by no discernible facial action. The identified clusters were relatively stable across time and comparable to the facial activity patterns found previously for experimental heat pain.ConclusionsThese findings corroborate the hypothesis that facial expressions of acute pain are not uniform. Instead, they are composed of different combinations of pain‐indicative facial responses, with one omnipresent response, namely, “narrowed eyes”. Raising awareness about these inter‐individually different “faces of pain” could improve the recognition and, thereby, its diagnostic training for professionals, like nurses and physicians.SignificanceSimilar to experimental pain, facial activity during evoked pain episodes in shoulder pain patients could be clustered into distinct faces of pain. Each cluster was composed of different combinations of single facial responses, namely: narrowed eyes, which is displayed either alone or in combination with opened mouth or wrinkled nose, or furrowed brows and closed eyes. These distinct faces of pain may inform the training of professionals and computers how to best recognize pain based on facial expressions.