bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone imaging modality precision and agreement between DXA, pQCT, and HR-pQCT
Authors: Mesinovic Jakub , Breasail Mícheál Ó , Burt Lauren A , Shore-Lorenti Cat , Zebaze Roger , Lim Camelia Q E , Ling Zihui , Ebeling Peter R , Scott David , Zengin Ayse 
Published: December 2024

Abstract
Quantifying precision error for DXA, peripheral QCT (pQCT), and HR-pQCT is crucial for monitoring longitudinal changes in body composition and musculoskeletal outcomes. Agreement and associations between bone variables assessed using pQCT and second-generation HR-pQCT are unclear. This study aimed to determine the precision of, and agreement and associations between, bone variables assessed via DXA, pQCT, and second-generation HR-pQCT. Thirty older adults (mean age: 64.2 ± 8.0 yr; women: 67%) were recruited. DXA scans were performed at the total hip, lumbar spine, and whole body. Distal (4%) and proximal (30%/33%/66%) skeletal sites at the radius and tibia were scanned with pQCT and/or HR-pQCT. Root-mean-squared coefficients of variation (%CVRMS) were calculated to define precision errors, and Bland–Altman plots assessed agreement between densitometric estimates. Pearson correlations and linear regression explored relationships between bone variables at different skeletal sites and proportional bias, respectively. Precision errors ranged between 0.55% and 1.6% for DXA, 0.40% and 4.8% for pQCT, and 0.13% and 30.7% for HR-pQCT. Systematic bias was identified between pQCT- and HR-pQCT-determined radius and tibia volumetric BMD (vBMD) estimates (all p&lt;.001). Proportional bias was not observed between vBMD measures at any skeletal site (all p&gt;.05). pQCT- and HR-pQCT-determined total, trabecular, and cortical vBMD and estimates of bone strength at the radius and tibia were strongly correlated (all p&lt;.05). Precision error was low for most bone variables and within the expected range for all imaging modalities. We observed significant systematic bias, but no proportional bias, between pQCT- and second-generation HR-pQCT-determined vBMD estimates at the radius and tibia. Nevertheless, measures of bone density and strength were strongly correlated at all skeletal sites. These findings suggest that although bone density and strength estimates from both imaging modalities are not interchangeable, they are strongly related and likely have similar fracture prediction capabilities.
Successful treatment of adult cherubism with a 60 mg denosumab 6-monthly regimen
Authors: Le Minh V , Sim Felix , Varatharajah Kapilan , Goh Asher , Yates Christopher J 
Published: December 2024

Abstract
Cherubism is a rare autosomal dominant skeletal dysplasia, affecting the maxilla and/or mandible. The condition typically has childhood onset, followed by progression until puberty, with subsequent regression. Cherubism lesions share histological features with giant cell tumor of bone, where high-dose monthly denosumab is an effective medical treatment. Therefore, high-dose denosumab has also been trialed in children with cherubism with positive outcomes. However, the role of denosumab in adult cherubism, particularly a lower dose and frequency, has not been established. We present the case of a 60-year-old man with cherubism, reviewed for a new 39 × 21 mm left mandibular lesion. The patient had multiple surgeries up to the age of 30 for tumors in the right maxilla and mandible. Given the impact of further surgery on his appearance and quality of life, the patient was referred to Endocrinology for consideration of medical therapy. His bone turnover markers were slightly elevated with normal calcium, phosphate, 25-OH vitamin D, and parathyroid hormone levels. A bone density scan showed lumbar spine osteopenia. He was commenced on 60 mg denosumab 6-monthly with excellent clinical and radiological responses over the next 30 months. The most recent CT mandible showed a sustained reduction in the lesion size, measuring 36 × 18 mm, with osteoid formation and improvement in cortical thinning. Surgery is no longer indicated. No adverse effects from denosumab were reported in the patient. This is the first study to report the efficacy and safety of a low-dose denosumab regimen in the management of cherubism. This treatment approach was able to prevent major surgery and minimize denosumab-related adverse effects. While the optimal treatment duration remains unclear, the patient will continue with 60 mg denosumab 6-monthly in the short-term given the favorable response. In summary, a low-dose denosumab regimen should be considered for patients with cherubism, particularly those with contraindications or preferences to avoid surgery.
New species of deep-sea Galatheoidea (Anomura: Galatheidae, Munididae, Munidopsidae) from Central Pacific seamounts, with remarks on their phylogenetic placement, habitat associations, and significance for the biogeography of squat lobsters
Authors: Rodríguez-Flores Paula C 
Published: December 2024

Abstract
Seamounts in the Central Pacific Ocean remain largely unexplored. Squat lobsters, a major deep-sea invertebrate group, are poorly known in this area, whereas recent sampling efforts in the Western Pacific have resulted in a populated database of Galatheoidea Samouelle, 1819. Material recently collected by the E/V Nautilus during several expeditions to Central Pacific seamounts is reviewed herein, revealing the presence of 16 species. Ten species constitute geographic range expansions, and five are new taxa: Trapezionida herculessp. nov., T. tapinasp. nov., Typhlonida annieaesp. nov., Munidopsis giribetisp. nov., and M. nemosp. nov. Using 3D imaging via micro-CT scanning and molecular phylogenetic analysis of COI and 16S mitochondrial genes, these species are described and illustrated, and their phylogenetic positions are revealed. Several of the new species represent highly divergent lineages not closely related to known species, indicating a need to continue exploring the deep ocean in the Central Pacific. The study herein also describes the habitats and biological associations of these species, ranging from corals to chemosynthetic environments. The new data fill an important geographic gap in the distribution of squat lobster species and contribute to understanding the speciation processes and connectivity among seamounts in the Pacific Ocean.
Individual variation and selection for phenotypic plasticity of laying date and clutch size across different environmental conditions in Tree swallow (Tachycineta bicolor)
Authors: Tremblay Audrey , Pelletier Fanie , Macdonald Andrew , Garant Dany 
Published: December 2024

Abstract
Several studies have emphasized that phenotypic plasticity should be a key mechanism to cope with current rapid environmental changes by allowing individuals to quickly express new adaptive phenotypes. Yet, few studies have investigated the evolutionary potential of plasticity for multiple traits simultaneously and using several different environmental variables. Here, we assess the extent of variation in, and the selection acting on phenotypic plasticity of key ecological traits, laying date, and clutch size, using five environmental variables, in a Tree swallow (Tachycineta bicolor) population monitored since 2004. While we found some variation among females in their mean laying date and plasticity, we found evidence of selection acting only on mean laying date. We found no variation among females in mean clutch size or plasticity, such that we could not assess selection acting on either. Our results suggest that the evolutionary potential of plasticity in the population under study is limited, especially for clutch size. More studies investigating plasticity in wild populations and incorporating multiple traits and environmental variables are needed to understand the future responses of animal populations to environmental changes.
Can the compressed sensing theory be utilized in active source surface wave exploration? A primary result
Authors: Cao Jingjie , Liu Jiang , Yin Hanjun , Cai Zhicheng , Yang Qiyan , Yang Helong , Zhu Yuefei 
Published: December 2024

Abstract
Active source surface wave exploration is a crucial technique for delineating shallow underground structures, widely utilized in geological engineering, urban geology, environmental geology, geological hazard assessment, and related fields. Seismic data acquisition plays a pivotal role in active source surface wave exploration techniques, which accounts for most costs. Consequently, research into low-cost acquisition methods holds great significance for active source surface wave exploration. Compressed sensing theory, a novel sampling paradigm, has been proven to facilitate cost-saving measures in certain geophysical prospecting techniques. However, its potential has not yet been investigated within the realm of surface wave exploration. This study explores the feasibility of applying compressed sensing theory in shallow seismic surface wave exploration. An edge-preservation piecewise random sampling method is employed as the compressed sensing sampling strategy, and data reconstruction is accomplished through a damped rank-reduction technique. The fully sampled and reconstructed data undergo identical surface wave data processing procedures, including dispersion spectrum calculation, and dispersion curve inversion. Simulated and field surface wave data experiments demonstrate that the reconstructed data obtained via compressed sensing theory can achieve comparable results to conventionally sampled data. Based on this theory, it is possible to significantly reduce the requisite number of equipment and field workload, making it a promising way for shallow subsurface structure detection.
Of Caribbean ‘white elephants’
Authors: Ostapkowicz Joanna 
Published: December 2024

Abstract
Britain amassed extensive collections from its Caribbean colonies from the seventeenth century onwards, including significant holdings of pre-Columbian archaeological materials. But it is not until the nineteenth century that there is more substantive documentation for some of the most prized artefacts now held in British museum collections, including wooden duhos (ceremonial chairs). These were circulated between collectors before their deposit in museums; their movements, in some instances, echoing the equally political and strategic gifting of these objects among the originating Indigenous communities. Their discovery – whether on-island or in antique shops – and the discussions they elicited among those who acquired or were given them, expose contemporary ideas about their nature and value. This paper focuses on one rare category of pre-Columbian Caribbean artefact – the duho – as represented by examples acquired by six collectors during the height of British imperialism. It traces these objects’ movements from discovery or collection to museum acquisition through the hands of not only Caribbean locals, colonial officials and military men, but also some of the key figures in British ethnographic collecting, including Augustus Wollaston Franks and William Oldman.
The third order Nickel Fibonacci numbers
Authors: Yamaç Akbiyik Seda 
Published: December 2024

Abstract
Using the technique of characteristic equations and De Moivre-type identity, this article defines the third order Nickel Fibonacci sequence, the third order Nickel Lucas and a modified third order Nickel Fibonacci sequence. We obtain some well-known identities for the sequences such as the Binet’s identity, Cassini identity, generating functions, and matrix representations. Also, we present D’Ocagne’s identity and Melham’s identity. We develop and illustrate a new encryption/decryption algorithms in which the keys are the Nickel Fibonacci matrices. Moreover, we give MATLAB-R2017a codes for encryption and decryption algorithms.
Ganaspis kimorum (Hymenoptera: Figitidae), a promising parasitoid for biological control of Drosophila suzukii (Diptera: Drosophilidae)
Authors: Stahl Judith M , Wang Xingeng , Abram Paul K , Biondi Antonio , Buffington Matthew L , Hoelmer Kim A , Kenis Marc , Lisi Fabrizio , Rossi-Stacconi Marco Valerio , Seehausen M Lukas , Vossen Ariane , Wong Warren H L , Daane Kent M 
Published: December 2024

Abstract
Ganaspis Foerster includes several cryptic species that are important larval parasitoids of the invasive pest Drosophila suzukii (Matsumura), spotted-wing drosophila (SWD). Drosophila suzukii, native to Asia, was first discovered in 2008 in North America and Europe, becoming a devastating pest of soft-skinned fruit crops. Biological control could be among the safest, most environmentally benign, and cost-effective methods for long-term and landscape-level management of this invasive pest. Foreign exploration in East Asia discovered several major larval D. suzukii parasitoids. One of them was initially described as Ganaspis brasiliensis (Ihering) and consisted of 2 major genetic groups (G1 and G3). The groups are now recognized as 2 different species, Ganaspis kimorum Buffington and Ganaspis lupini Buffington. The more host-specific species G. kimorum was selected and approved for field release in the United States in 2021 and has been widely released since 2022. Here, we provide a comprehensive overview of the parasitoid’s taxonomy, current known distribution, biology, ecology, mass-rearing methods, and biological control potential.
Outcome of osimertinib-treated patients with epidermal growth factor receptor mutation-positive nonsmall cell lung cancer requiring dose reduction: a secondary analysis of the Reiwa study
Authors: Awano Nobuyasu , Yoh Kiyotaka , Usui Kazuhiro , Hosomi Yukio , Kishi Kazuma , Naka Go , Watanabe Kageaki , Tamano Shu , Uemura Kohei , Kunitoh Hideo 
Published: December 2024

Abstract

Background
Osimertinib is effective in patients with epidermal growth factor receptor (EGFR) mutation-positive nonsmall cell lung cancer (NSCLC). However, some patients require osimertinib dose reduction because of adverse events. This study assessed the characteristics of osimertinib dose reduction and compared the efficacies of reduced-dose and regular-dose osimertinib.

Methods
This multicenter, prospective, observational study enrolled patients with EGFR mutation-positive NSCLC who started first-line osimertinib treatment between September 2018 and August 2020. We categorized the patients into two groups: those who required dose reduction during osimertinib treatment (reduction group) and those who continued osimertinib treatment at a dose of 80 mg/day without dose reduction (nonreduction group). The primary endpoints were progression-free survival (PFS) and pattern of progression, whereas the secondary endpoints included overall survival (OS) and reasons for osimertinib dose reduction.

Results
Of the included 575 patients, 175 (30.4%) and 400 (69.6%) were classified into the reduction and nonreduction groups, respectively. PFS was significantly better in the reduction group than in the nonreduction group [hazard ratio (HR) = 0.67, 95% confidence interval (CI) = 0.54–0.84; P &lt;0.001]. Meanwhile, the pattern of progression and OS (HR = 0.82, 95% CI = 0.62–1.08; P = 0.15 ) did not differ significantly between the two groups. Osimertinib was reduced due to physician's decision or adverse events and the main reasons were rash and gastrointestinal symptoms such as nausea and diarrhea.

Conclusions
Many patients require osimertinib dose reduction due to adverse events, but this process does not adversely affect the drug efficacy.
Identifying and Exploiting Alpha in Linear Asset Pricing Models with Strong, Semi-Strong, and Latent Factors
Authors: Pesaran M Hashem , Smith Ron P 
Published: December 2024

Abstract
The risk premia of traded factors are the sum of factor means and a parameter vector, we denote by ϕ, which is identified from the cross-sectional regression of αi on the vector of factor loadings, βi. If ϕ is non-zero, then αi are non-zero and one can construct “phi-portfolios” which exploit the systematic components of non-zero alpha. We show that for known values of βi and when ϕ is non-zero, there exist phi-portfolios that dominate mean–variance (MV) portfolios. This article then proposes a two-step bias corrected estimator of ϕ and derives its asymptotic distribution allowing for idiosyncratic pricing errors, weak missing factors, and weak error cross-sectional dependence. Small sample results from extensive Monte Carlo experiments show that the proposed estimator has the correct size with good power properties. This article also provides an empirical application to a large number of U.S. securities with risk factors selected from a large number of potential risk factors according to their strength and constructs phi-portfolios and compares their Sharpe ratios to MV and S&P portfolios.
Water sources selected for immature development of some African rainforest dwelling mosquitoes under different landscapes in Cameroon
Authors: Mayi Marie Paul Audrey , Kowo Cyril , Forfuet Foncha David , Anong Damian Nota , Fonda Andongma Esack , Elad Mirabel , Djomo Charlène Jordane Piam , Tchuinkam Timoleon , Sehgal Ravinder N M , Cornel Anthony John 
Published: December 2024

Abstract
Little is known about the behaviors of African equatorial rain forest mosquito species and their potential role as sylvatic and bridge-vectors of various pathogens of animal and public health. In 2016 and 2017, the diversity and sources of water supporting immature development of mosquitoes in Talangaye Rainforest (South West Cameroon) before, during and after deforestation were investigated. Mosquito eggs, larvae and pupae were collected from 12 natural, seminatural, and artificial water sources and reared to adults. A total of 595 adult mosquitoes belonging to seven genera and at least 43 species were identified. Culex was the most abundant (56.3%) and was encountered in the majority in bamboo pots. Aedes and Uranotaenia species were mostly found in rock pools, while Anopheles and Hodgesia species solely prefer stream pools. In terms of mosquito abundance, rock pools were the most productive (29.91%) followed by bamboo pots (24.7%). Natural sites such as rock pools, tree holes, and stream pools recorded a greater number of species (S = 21, 14 and 12 respectively). During the rainy season, rock pools (46.23%) and bamboo pots (18.7%) were the most productive water bodies, while in the dry season, bamboo pots (35.71%) and stream pools (35.71%) harbored the most mosquitoes. The disturbed and pristine-like habitats had the greatest number of mosquitoes and breeding sites compared to palm plantation. This study provides some useful data on water sources used for immature development of forest mosquito species in Southwest Cameroon and how some species might adapt to changing landscapes, especially due to deforestation.
TP53 missense allele predisposing to high risk of breast cancer but not pediatric cancers
Authors: Lolas-Hamameh Suhair , Lieberman Sari , Sarahneh Alaa , Walsh Tom , Lee Ming K , Gulsuner Suleyman , Rabie Grace , Beeri Rachel , Aburayyan Amal , Mandell Jessica B , Fridman Hila , Lazer-Derbeko Galit , Klopstock Tehila , Freireich Orit , Lahad Amnon , King Mary-Claire , Levy-Lahad Ephrat , Kanaan Moien N 
Published: December 2024

Abstract
Pathogenic TP53 germline variants cause young-onset breast cancer and other cancers of the Li-Fraumeni syndrome (LFS) spectrum, but the clinical consequences of partial-loss-of function TP53 variants are incompletely understood. In the consecutive cohort of Palestinian breast cancer patients of the Middle East Breast Cancer Study (MEBCS), breast cancer risk among TP53 p.R181C heterozygotes was 50% by age 50 years and 81% by age 80 years. In contrast, prevalence of pediatric cancers in the MEBCS was similar among first-degree relatives of TP53 p.R181C carriers (3/519 = 0.0058) and first-degree relatives of MEBCS patients with no pathogenic germline variant in any known breast cancer gene (7/1082 = 0.0065; odds ratio [OR] = 0.90, 95% confidence interval [CI] [0.23 to 3.49], Fisher P = .90 [2-tailed]). This result suggests that in families harboring this TP53 allele, genetic testing in children is unwarranted, and screening children for LFS tumors is unnecessary. More generally, some TP53 missense alleles can predispose to very high risk of breast cancer without pleiotropic effects.
Menopausal hormone therapy: assessing associations with breast and colorectal cancers by familial risk
Authors: MacInnis Robert J , Jenkins Mark A , Milne Roger L , John Esther M , Daly Mary B , Andrulis Irene L , Colonna Sarah V , Phillips Kelly-Anne ,   kConFab Investigators, Le Marchand Loic , Newcomb Polly A , Phipps Amanda I , Schmit Stephanie L , Macrae Finlay A , Buchanan Daniel D , Gallinger Steven , Pai Rish K , Samadder Niloy J , Giles Graham G , Southey Melissa C , Hopper John L , Terry Mary Beth 
Published: December 2024

Abstract
Menopausal users of hormone replacement therapy (HRT) are at increased breast cancer risk and decreased colorectal cancer (CRC) risk compared with individuals who have never used HRT, but these opposing associations may differ by familial risk of breast cancer and CRC. We harmonized data from 3 cohorts and generated separate breast cancer and CRC familial risk scores based on cancer family history. We defined moderate or strong family history as a risk score of 0.4 or higher, where 0.4 was equivalent to a 50-year-old woman with 1 parent diagnosed with either breast cancer or CRC at 55 years of age. Of 24 486 women assessed, 1243 and 405 were diagnosed with incident breast cancer and CRC, respectively. For breast cancer, menopausal HRT ever use versus never use hazard ratios were 1.27 (95% CI = 1.11 to 1.45) for a breast cancer familial risk score below 0.4 and 1.01 (95% CI = 0.82 to 1.25) for a breast cancer familial risk score of 0.4 or higher (Pdifference = .08). For CRC, menopausal HRT hazard ratios were 0.63 (95% CI = 0.50 to 0.78) for a CRC familial risk score below 0.4 and 1.21 (95% CI = 0.73 to 2.00) for a CRC familial risk score of 0.4 or higher (Pdifference = .03). Associations with menopausal HRT use that apply to the general population may not hold for women at moderate or strong familial risk of these cancers.
Resurgence of Pediatric Mycoplasma pneumoniae Infections in Southeast Texas, November 2023-June 2024
Authors: Danner Margaret Taylor , Binns Heather Colvin , Nguyen Khanh , Johnson Coreen , Dunn Jim , Niles Denver , Nguyen Diana K 
Published: December 2024

Abstract
We conducted a retrospective review of children tested for Mycoplasma pneumoniae from January 1, 2020 to June 30, 2024. M. pneumoniae polymerase chain reaction positivity increased starting in November 2023, peaking at 18.3% in June 2024. During the resurgence, children with laboratory-confirmed infection often had severe respiratory disease or extrapulmonary manifestations.
Antibiotic Management and Imaging Practices of Sinusitis-Related Epidural Empyema Among Pediatric Centers
Authors: Tan Jenna , Kronman Matthew P , Brothers Adam W , Pak Daniel J , McDonald Derry , Weissman Scott J , Gerber Jeffrey S , Hersh Adam L , Newland Jason G , Wirtz Ann L , Konold Victoria J L 
Published: December 2024

Abstract
A survey of pediatric infectious diseases clinicians from 49 children’s hospitals demonstrated variability across institutions in the treatment of epidural empyema from sinus extension, including antibiotic route, selection, and impact of neuroimaging on determining duration of therapy.