bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimierung der chirurgischen Behandlung Brandverletzter: Auszüge aus der fachübergreifenden S2k-Leitlinie „Behandlung thermischer Verletzungen des Erwachsenen“
Authors: Rennekampff Hans-Oliver , Mirastschijski Ursula , Aumann Eva , Bargfrede Heiko , Gille Jochen , Haas Robert , Hartmann Bernd , Hirche Christoph , Hirsch Ute , Horter Johannes , Kapalschinksi Nicolai , Kheiri Tanja , Kopp Rüdger , Krauß Sabrina , Kückelhaus Maximilian , Lehnhardt Marcus , Pauli Holger , Rubenbauer Johannes , Schiefer Jennifer Lynn , Sinnig Mechthild , Sorg Heiko , Stolle Annette , Suchodolski Klaudiusz , Wollborn Stefan , Ziegenthaler Hans , Ziesing Stefan , Menke Henrik 
Published: September 2020

Zusammenfassung
Hintergrund Trotz Brandschutzmaßnahmen und Aufklärung erleiden ca. 0,5 Millionen Menschen pro Jahr in Deutschland Verbrennungen. Im Jahr 2018 mussten fast 2000 Schwerstbrandverletzte in deutschen Verbrennungszentren behandelt werden. Brandverletzungen stellen eine schwerwiegende Erkrankung mit hoher Mortalität und langfristigen Folgen für den Patienten dar.
Methodik und Ergebnisse Ziel dieses Übersichtsartikels ist es, eine Zusammenfassung der derzeit gültigen Leitlinie zur Behandlung von Verbrennungen im Erwachsenenalter (https://www.awmf.org/leitlinien/detail/ll/044–001.html) zu präsentieren, wobei der Fokus auf folgenden Aspekten liegt: 1. der Akutbehandlung der Brandwunde am Unfallort, 2. der Entscheidungsfindung zur Verlegung in ein Brandverletztenzentrum, 3. der chirurgischen Wundversorgung mit Debridement und Hauttransplantation und 4. der Nachsorge. Die S2k-Leitlinie basiert auf aktueller Literatur und dem Konsens von 11 an der Behandlung Brandverletzter beteiligter Fachgesellschaften.
Zusammenfassung Dieser Übersichtsartikel enthält gewichtete Empfehlungen zur Behandlung von Brandwunden erwachsener Patienten in Deutschland. Der Artikel soll Ärzten und medizinischem Personal in der Akutsituation vor Ort und in der Klinik die Entscheidung über die notwendige Behandlung erleichtern. Hiermit soll die Behandlungsqualität für Patienten verbessert werden.
Sympathetic Ophthalmia – a Contribution to Immunology, Clinic and Current Imaging
Authors: Rua David , Pohlmann Dominika , Pleyer Uwe 
Published: September 2020

Abstract
Background Sympathetic ophthalmia (SO) is a rare inflammation of an operated or injured eye that spreads to the fellow eye. It is typically a bilateral granulomatous panuveitis. The traumatized eye is referred to as inciting eye and the fellow eye as sympathizing eye. The pathophysiology of the disease is not entirely understood, but there is strong evidence of an autoimmune genesis.
Patients/Material and Methods A selective literature search on epidemiology, immunology, clinical features and risk factors of SO was carried out. In addition, our own experience using multimodal imaging for this clinical entity was introduced.
Results In the literature, the incidence after traumatic eye injuries is 0.1 – 3% and approximately 0.01% after intraocular surgery. Among the iatrogenic causes, vitreoretinal surgery has the highest rate of SO, presumably due to disruption of the blood-retinal barrier and involvement of retinal and choroidal tissue, which are susceptible to anterior traction, phthisis and chronic inflammation. In 90% of patients, the disease develops within a year following the eliciting event and is associated with a potentially bilateral risk of blindness. Typical symptoms include bilateral visual impairment with photophobia, dull pain and photopsia. The spectrum of clinical manifestations ranges from granulomatous anterior uveitis and vitritis, to choroiditis, serous retinal detachment and Dalen-Fuchs nodules in the context of posterior involvement. The diagnosis of SO is generally based on clinical presentation and is supported by imaging methods. These primarily comprise
fluorescein and indocyanine green angiography, which are increasingly being supplemented by non-invasive methods such as optical coherence tomography. They can provide important information for assessment of severity, differential diagnosis as well as for disease monitoring. The differential diagnosis includes i. a. Vogt-Koyanagi-Harada syndrome, ocular sarcoidosis and the rare phacoanaphylactic endophthalmitis. Immediate systemic high-dose steroid therapy is used as initial treatment. The course of the disease is often relapsing to chronic progressive. Immunomodulators such as ciclosporine A, azathioprine, cyclophosphamide, mycophenolate mofetil, and biologics are increasingly being used and contribute to the significantly better prognosis of the disease. Generally, SO can be triggered by any kind of intraocular intervention.
Conclusion SO remains a threatening clinical diagnosis that poses diagnostic and therapeutic challenges. It can be triggered post-traumatic, but also any intraocular surgery. This should be taken into account when assessing the indication for intraocular eye surgery, especially in eyes with reduced visual outcome.
Synthesis of Optically Active Hydroxyalkyl Cycloheptatrienes: A Key Step in the Total Synthesis of 6,11-Methylene-LXB4
Authors: Nubbemeyer Udo , Nava Analuisa , Trippe Lukas , Frank Andrea , Andernach Lars , Opatz Till 
Published: September 2020

AbstractStarting from methyl cycloheptatrienyl-1-carboxylate, 6-acylation was successfully achieved employing glutaryl chloride in the presence of AlCl3 under controlled reaction conditions to furnish keto carboxylic acid product. After protection of this keto carboxylic acid as tert-butyl ester, reagent-controlled enantioselective reductions delivered configuration-defined methyl-6-hydroxylalkyl cycloheptatriene-1-carboxylates with up to 80% ee. Whereas simple NaBH4 reduction of the keto carboxylic acid and subsequent lactonization afforded a methyl-6-tetrahydropyranonyl cycloheptatriene-1-carboxylate. Resolution using chiral HPLC delivered the product enantiomers with up to >99% ee Finally, ECD analyses enabled structure elucidation. The products are used as key intermediates in enantioselective 6,11-methylene-lipoxin B4 syntheses.
C–H Functionalization Reactions of Phenyl and Vinyl Carbocations Paired with Weakly Coordinating Anions
Authors: Nelson Hosea M. , Popov Stasik , Shao Brian , Bagdasarian Alex L. , Wigman Benjamin 
Published: September 2020

Carbocations have played a central role in the chemical sciences for over a century. In a synthetic setting, most methods utilize stabilized tricoordinate carbocations, while there are far fewer examples of reactions featuring nonstabilized dicoordinate cations. Here, we provide an overview of recent developments in the generation of high-energy carbocations mediated by weakly coordinating anions and the C–H insertion reactions of such carbocations. Moreover, we discuss mechanistic studies of these catalytic C–H insertion reactions aimed at furthering our understanding of the reactive nature of these rarely invoked cationic intermediates.1	Introduction2	Background: Phenyl Carbocations3	Silylium/Carborane-Catalyzed C–H Insertion Reactions of Phenyl Carbocations4	Silane-Fueled, Weakly Coordinating Anion-Catalyzed, Reductive C–H Insertion Reactions of Vinyl Carbocations5	C–H Insertion Reactivity of Vinyl Carbocations under Basic Conditions6	Conclusion and Outlook
A cicatrização do manguito rotador
Authors: de Almeida Filho Ildeu Afonso , Coelho Daniel Andrade 
Published: September 2020

ResumoO presente artigo aborda de forma ampla os aspectos que interferem no processo de cicatrização do manguito rotador. São considerados hábitos de vida como tabagismo e alcoolismo, fatores sistêmicos como diabetes mellitus, hipertensão arterial e obesidade bem como fatores locais, dentre os quais aqueles relacionados ao pré, per e pós operatório. A partir de uma extensa revisão da literatura, com a citação de 60 artigos científicos tanto da literatura ocidental como oriental, os autores pretendem aprofundar no tema trazendo para a prática médica condutas embasadas em novos conceitos estabelecidos.
New-Onset Atrial Fibrillation in Sepsis: A Narrative Review
Authors: Aibar Jesus , Schulman Sam 
Published: September 2020

AbstractAtrial fibrillation (AF) is a frequently identified arrhythmia during the course of sepsis. The aim of this narrative review is to assess the characteristics of patients with new-onset AF related to sepsis and the risk of stroke and death, to understand if there is a need for anticoagulation. We searched for studies on AF and sepsis on PubMed, the Cochrane database, and Web of Science, and 17 studies were included. The mean incidence of new-onset AF in patients with sepsis was 20.6% (14.7% in retrospective studies and 31.6% in prospective). Risk factors for new-onset AF included advanced age, white race, male sex, obesity, history of cardiopulmonary disease, heart or respiratory failure, and higher disease severity score. In-hospital mortality was higher in patients with than in those without new-onset AF in 10 studies. In four studies the overall intensive care unit and hospital mortality rates were comparable between patients with and without new-onset AF, while three other studies did not provide mortality data. One study reported on the in-hospital incidence of stroke, which was 2.6 versus 0.69% in patients with or without new-onset AF, respectively. Seven of the studies provided follow-up data after discharge. In three studies, new-onset AF was associated with excess mortality at 28 days, 1 year, and 5 years after discharge of 34, 21, and 3% patients, respectively. In two studies, the mortality rate was comparable in patients with and without new-onset AF. Postdischarge stroke was reported in five studies, whereof two studies had no events after 30 and 90 days, one study showed a nonsignificant increase in stroke, and two studies demonstrated a significant increase in risk of stroke after new-onset AF. The absolute risk increase was 0.6 to 1.6%. Large prospective studies are needed to better understand the need for anticoagulation after new-onset AF in sepsis.
Correlation of Obesity with External Cephalic Version Success among Women with One Previous Cesarean Delivery
Authors: McLaren Rodney , Atallah Fouad , Fisher Nelli , Minkoff Howard 
Published: September 2020

AbstractObjective Our aim was to assess the correlation of body mass index (BMI) with the success rate of external cephalic version (ECV) among women with one prior cesarean delivery.Study Design A cross-sectional study of pregnant women with one previous cesarean delivery who underwent ECV. The relationship between BMI and success rate of ECV was assessed. Adverse outcomes were also compared between women with an ECV attempt, and women who had a repeat cesarean delivery. Data were extracted from the U.S. Natality Database from 2014 to 2017. Pearson's correlation coefficient was performed to assess the relationship between BMI and success rate of ECV.Results There were 2,329 women with prior cesarean delivery underwent an ECV attempt. The success rate of ECV among the entire cohort was 68.3%. There was no correlation between BMI and success rate of ECV (r = 0.024, p = 0.239). Risks of adverse maternal and neonatal outcomes were similar between the ECV attempt group and the repeat cesarean delivery group.Conclusion There was no correlation of BMI with the rate of successful ECV among women with one prior cesarean delivery. Given the similar success rates of ECV and adverse outcomes, obese women with one prior cesarean delivery should be offered ECV.
A Rule-Based Data Quality Assessment System for Electronic Health Record Data
Authors: Wang Zhan , Talburt John R. , Wu Ningning , Dagtas Serhan , Zozus Meredith Nahm 
Published: September 2020

Abstract
Objective Rule-based data quality assessment in health care facilities was explored through compilation, implementation, and evaluation of 63,397 data quality rules in a single-center case study to assess the ability of rules-based data quality assessment to identify data errors of importance to physicians and system owners.
Methods We applied a design science framework to design, demonstrate, test, and evaluate a scalable framework with which data quality rules can be managed and used in health care facilities for data quality assessment and monitoring.
Results We identified 63,397 rules partitioned into 28 logic templates. A total of 819,683 discrepancies were identified by 4.5% of the rules. Nine out of 11 participating clinical and operational leaders indicated that the rules identified data quality problems and articulated next steps that they wanted to take based on the reported information.
Discussion The combined rule template and knowledge table approach makes governance and maintenance of otherwise large rule sets manageable. Identified challenges to rule-based data quality monitoring included the lack of curated and maintained knowledge sources relevant to data error detection and lack of organizational resources to support clinical and operational leaders with investigation and characterization of data errors and pursuit of corrective and preventative actions. Limitations of our study included implementation within a single center and dependence of the results on the implemented rule set.
Conclusion This study demonstrates a scalable framework (up to 63,397 rules) with which data quality rules can be implemented and managed in health care facilities to identify data errors. The data quality problems identified at the implementation site were important enough to prompt action requests from clinical and operational leaders.
Group A Rotavirus G1P[6] Associated Fatalities in Diarrheic Nigerian Infants, Possible Impact of Enterovirus Environmental Enteric Dysfunction, and Implications for Rota-Vaccinology
Authors: Babalola Michael Oluyemi 
Published: September 2020

AbstractGroup A rotavirus (RVA) diarrhea disease and mortality are yet unabated, particularly in developing countries. As global knowledge of specific strains associated with infant mortality is crucial for successful vaccination efforts, candidate RVA strains detected in mortality and fatal cases of severely diarrheic hospitalized infants in Akure, Nigeria were investigated.Fecal samples from comatose patients were tested for RVAs, other diarrhea viruses, and enteric bacterial pathogens. Genomic dsRNA was extracted from 10% rotavirus positive stool suspension, the VP4 and VP7 genes were reverse transcribed and amplified by one-step reverse transcription polymerase chain reaction (PCR) and genotyped by seminested multiplex PCR. Amplicons were sequenced, aligned by ClustalW, and phylogenetic analyses were conducted in MEGA6. Sequences data were deposited to GenBank and DDBJ.Medical examination and microbiological analyses upheld viral diarrhea. EIA revealed RVA and enterovirus. PCR identified virulent RVA strain GIP[6] whose VP7 nucleotide sequences shared a common cluster with Cuban isolate G1P[6], while the VP4 P[6] sequences were related to Asian strains. Reassortant RVA G1P[6] was found in fatal diarrhea cases and mortality of a Nigerian child. RVA coinfection with enterovirus and associated biomarkers of environmental enteric dysfunction in infantile diarrhea should henceforth be evaluated. Current rotavirus vaccines may fare badly against the prevailing virulent strains. The disease severity and outcome necessitates a wider epidemiological study, a review and inclusion of the P[6] genotype in future rotavirus vaccines.
Impact of Patient Characteristics on Treatment Outcomes in Symptomatic Venous Thromboembolism: Results of HOKUSAI-VTE Randomized Trial Analysis
Authors: van Hout Ben , Hawe Emma , Cohen Alexander T. 
Published: September 2020

Abstract
Introduction In patients with venous thromboembolism (VTE), direct oral anticoagulants (DOACs) such as edoxaban, apixaban, dabigatran, and rivaroxaban are more convenient, safer, and just as effective as vitamin K antagonists (VKAs). Limited information is known about the effects of patient characteristics on VTE efficacy and safety of DOACs compared with VKAs, without appropriate effect modifier adjustment comparisons of DOACs may be biased. This study considers the effect of variables that can modify the efficacy and safety of edoxaban and warfarin, using patient-level data.
Materials and Methods The primary efficacy and safety outcomes in the HOKUSAI-VTE study were VTE recurrence and clinically relevant bleeding, respectively. Potential effect modifiers were age, creatinine clearance, and weight. The relationship between the percentage of time in international normalized ratio (INR) control and outcomes were considered for the warfarin arm. Univariate and multivariate regression were performed for each patient characteristic.
Results The relationship between treatment and VTE recurrence differed by age (interaction p = 0.007) and by creatinine clearance (p = 0.05). VTE recurrence differed by age for patients in the warfarin arm but not for those in the edoxaban arm and differed by INR control in the warfarin arm (p < 0.005). A stronger relationship between creatinine clearance and clinically relevant bleeding was found in the warfarin arm than in the edoxaban arm (p = 0.04). Clinically relevant bleeding differed by the percentage of time in INR control in the warfarin arm (p < 0.005). Age appeared to be a more important effect modifier than creatinine clearance in patients with VTE.
Discussion The finding that efficacy in older patients was greater for those taking edoxaban than for those taking warfarin in the HOKUSAI-VTE study needs further investigation. Modification of the treatment effect by age for those taking warfarin might bias estimates of comparative effectiveness among DOACs if VKAs are the reference treatment.
The TV and Movies corpora
Authors: Davies Mark 
Published: September 2020

AbstractThis paper discusses the creation and use of the TV Corpus (subtitles from 75,000 episodes, 325 million words, 6 English-speaking countries, 1950s-2010s) and the Movies Corpus (subtitles from 25,000 movies, 200 million words, 6 English-speaking countries, 1930s–2010s), which are available atEnglish-Corpora.org. The corpora compare well to the BNC-Conversation data in terms of informality, lexis, phraseology, and syntax. But at 525 million words in total size, they are more than 30 times as large as BNC-Conversation (both BNC1994 and BNC2014 combined), which means that they can be used to look at a wide range of linguistic phenomena. The TV and Movies corpora also allow useful comparisons of very informal language across time (containing texts from the 1930s and later for the movies, and from the 1950s onwards for TV shows) and between dialects of English (such as British and American English).
Non-linear spherical collapse in tachyon models and a comparison of collapse in tachyon and quintessence models of dark energy
Authors: Rajvanshi Manvendra Pratap , Bagla J S 
Published: September 2020

Abstract
We study evolution of perturbations in dark matter and dark energy for spherical collapse using a completely self consistent, relativistic approach. We study tachyon models of dark energy using the approach outlined in Rajvanshi and Bagla (2018). We work with models that are allowed by current observations. We find that as with quintessence models allowed by observations, dark energy perturbations do not affect evolution of perturbations in dark matter in a significant manner. Perturbations in dark energy remain small for such models. We then take two different Lagrangians for dark energy: tachyon and quintessence models, reconstruct potentials to have same expansion history and then compare if two can be distinguished in the nonlinear regime. Any variations we find are only due to a different Lagrangian density, and allow a comparison of different classes of models in a fair manner. We find that dark matter perturbations carry no imprint of the class of dark energy models for the same expansion history: this is significant in that we can work with any convenient model to study clustering of dark matter. We find that the evolution of dark energy perturbations carries an imprint of the class of models and dark energy perturbations grow differently in tachyon models and quintessence models for the same expansion history. However, the difference between these diminishes for (1 + w) ≪ 1 and hence prospects for differentiating between models using characteristics of perturbations are limited in our Universe.
High-performance solid-state photon-enhanced thermionic emission solar energy converters with graded bandgap window-layer
Authors: Yang Yang , Xu Peng , Cao Weiwei , Zhu Bingli , Wang Bo , Bai Yonglin , Qin Junjun , Bai Xiaohong , Chen Zhen 
Published: September 2020

Abstract
To realize a high-performance solid-state photon-enhanced thermionic emission (SPETE) solar energy converter, in this study, a graded bandgap window layer is therefore adopted, throughout which the bandgap gradation is generated via the variation of Al composition in the

A

l

x

G

a

1
−
x

As

layer in the SPETE converter with a GaAs absorber. Based on one-dimension steady-state equation, an analytical model is formed in analyzing performance of the proposed device in our study. Theoretical simulation results indicate that not only are the losses of contact surface recombination being decreased via the bandgap-gradation-induced build-in electric field of the window layer, but also the photon-generated electrons are effectively collected, thereby improving the conversion efficiency. Moreover, the effect of bandgap energy of the contact surface and the width of the window layer on device performance is discussed. A trade-off of high-efficient SPETE converters is therefore realized between large contact surface bandgap and thin window layer width, to which the rationale lies in the improved process of electron collection facilitated by the enhanced build-in electric field rather than reducing the photon absorption in the window layer. Threshold values for barrier height at the emitting interface are presented to guarantee the ideal voltage-current characteristic. It is found that the threshold values of barrier increase with the increase in temperatures.