bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiolabelled Nanoparticles for Brain Targeting
Authors: Sethi Chopra Dimple 
Published: May 2020

Tumors like glioblastoma are inaccessible due to blood brain barrier. The permeability of radioisotopes can be improved by conjugating them with nanoparticles. The most common malignant adult brain tumor is glioblastoma, which has very poor patient prognosis. The mean survival for highly proliferative glioblastoma is only 10–14 months despite an aggressive radiotherapy and chemotherapy following debulking surgery. β− particle emitters like 131I, 90Y, 186/188Re, and 177Lu have been coupled with nanoparticles and used for treatment of glioblastoma. These radiopharmaceutical compounds have resulted in a stabilization and improvement of the neurological status with minimal side effects. Similarly, α particle emitters like 213Bi, 211At, and 225Ac are an innovative and interesting alternative. Alpha particles deliver a high proportion of their energy inside the targeted cells within a few micrometers from the emission point versus several millimeters for β− particles. Thus, α particles are highly efficient in killing tumor cells with minimal irradiation of healthy tissues and permits targeting of isolated tumor cells. This has been confirmed by subsequent clinical trials which showed better therapeutic efficacy and minimal side effects, thus opening a new and promising era for glioblastoma medical care using α therapy.
Analytics for Action: Assessing effectiveness and impact of data informed interventions on online modules
Authors: Hidalgo Rafael , Evans Gerald 
Published: May 2020

La efectividad del uso de las analíticas de aprendizaje es un tópico de gran relevancia en la literatura sobre el tema. Una revisión sistemática reciente encontró 689 artículos en este campo (Larrabee Sonderlund et al., 2019). Sin embargo, solamente 11 de los 689 artículos destacan el potencial de las intervenciones basadas directamente en el análisis de los datos disponibles. La Open University UK (OU) es una de las pocas instituciones que desarrolla e implementa sistemáticamente un marco de uso de las análiticas a gran escala. Este documento revisa el impacto de una parte de este marco: el proceso de Analytics for Action (A4A). Utilizando datos del curso académico 2017-18, revisamos los comentarios de los participantes y las intervenciones acordadas como parte del proceso.El proceso A4A implica la capacitación práctica del personal, seguida de reuniones sucesivas en las que se discuten los datos cuando el curso ya está disponible en línea. El objetivo del proceso es ayudar a los educadores a planificar y realizar intervenciones basadas en la evidencia, con el fin de mejorar la retención y satisfacción de los estudiantes. Los resultados de este estudio indican que los participantes están satisfechos con la capacitación y que las reuniones de apoyo están ayudando a proporcionar nuevas perspectivas sobre los datos. El alcance y la naturaleza de las intervenciones varían ampliamente, desde la no intervención hasta intervenciones que abarcan múltiples presentaciones (cohortes) del curso. En algunos casos, medir el impacto real de las acciones tomadas requerirá el análisis de los datos de otras presentaciones. El trabajo también presenta hallazgos que indican que todavía hay margen para mejorar el seguimiento de las acciones acordadas, el apoyo brindado a los equipos académicos para implementar tales acciones y la evaluación final del impacto en los resultados y satisfacción de los estudiantes.
CETA et mobilité de la main-d’oeuvre hautement qualifiée : une réelle innovation dans la gestion migratoire transatlantique?
Authors: Debuisson Aurélie 
Published: May 2020

Le XXIe siècle a été témoin d’une accélération de la mobilité des travailleurs temporaires hautement qualifiés de par l’abolition de toute une série d’entraves au commerce international, dont les accords de libre-échange se veulent les garants. Le commerce et la gestion migratoire sont guidés par des logiques d’action différentes. Il importe d’évaluer si le législateur, tant canadien qu’européen, a veillé à atteindre un équilibre entre ces deux domaines de plus en plus connectés dans les législations en vigueur de part et d’autre de l’Atlantique. Signé en octobre 2016 entre le Canada, l’Union européenne et ses États membres, l’Accord économique et commercial global, plus connu sous son acronyme anglais CETA, fait son entrée dans la gamme des instruments de gestion migratoire. L’hypothèse de recherche consiste à déterminer si le chapitre 10 du CETA, reprenant les dispositions concernant l’admission temporaire de certains travailleurs, s’inscrit dans une volonté de changement global des politiques migratoires et dans une nouvelle perception de ces dernières. Peut-on utiliser le terme d’innovation à tous les niveaux ? Si, sur le plan économique, le pari semble tenu, le CETA s’insérant dans la lignée des accords antérieurs de libre-échange, le bilan semble plus mitigé lorsque le travailleur hautement qualifié n’est plus uniquement considéré comme l’équivalent d’un bien ou d’un service. L’analyse approfondie des dispositions du chapitre 10 démontre qu’il n’existe pas de réponse innovante, apportée par le CETA, en ce qui concerne la gestion de la fuite des cerveaux. Cette dernière problématique serait en effet régulée si les questions de la libre circulation des travailleurs, de l’accès à la résidence permanente, du regroupement familial ou encore des droits de ces travailleurs avaient fait l’objet d’une attention particulière lors de l’adoption de ce nouvel accord. Force est de constater qu’elles demeurent les grandes oubliées.
TUER ENTRE NOUS
Authors: Bélanger David , Bérard Cassie 
Published: May 2020

Cet article s’intéresse au « retour » que fait le régionalisme, celui idyllique du début du xxe siècle, dans la littérature québécoise récente. Ce retour, plus précisément, rend compte de crimes dans un univers sachant difficilement les contenir. Dans Le discours sur la tombe de l’idiot (2008) de Julie Mazzieri, Le chasseur inconnu (2014) de Jean-Michel Fortier et Trois fois la bête (2015) de Zhanie Roy, nous rencontrons effectivement des meurtres, sans que les infrastructures ne permettent de les traiter : ni enquêteur, ni médecin légiste, ni quelque instance judiciaire n’apparaissent dans ces fictions. Une telle représentation du crime permet de conceptualiser ces oeuvres comme des « actualisations à distance », c’est-à-dire que le mouvement de retour s’avère sciemment problématisé selon les conceptions éthiques contemporaines. Par le biais des questions de l’origine et de l’autorité, comme interrogations au coeur de ces fictions critiques de l’idéal régionaliste, cet article entend éclairer ce geste de création important dans la production récente.
ÉCRIRE LA PÉRIPHÉRIE AU QUÉBEC
Authors: Kirouac Massicotte Isabelle 
Published: May 2020

Dans cette contribution, l’auteur poursuit la réflexion de Mathieu Arsenault
sur la ruralité trash à partir de la lecture de La déesse des mouches à
feu de Geneviève Pettersen et de Kuessipan de Naomi Fontaine.
Souhaitant s’éloigner d’une vision quelque peu misérabiliste du lieu périphérique,
elle s’attache à démontrer que l’écriture de la périphérie rend signifiants certains
non-lieux et qu’elle aménage des espaces de liberté liés à la ruralité ou encore aux
modes de vie marginaux. La cartographie des lieux périphériques — et le discours qui
la crée — fonde la régionalité de ces oeuvres en même temps qu’elle permet de mettre
au jour certaines facettes de cette tendance littéraire, dont elle tente d’esquisser
les contours en fin de parcours.
Visions multigénérationnelles de l’art sonore à Montréal
Authors: Dall’Ara-Majek Ana 
Published: May 2020

Partant d’une caractéristique de l’environnement artistique à Montréal – le
décloisonnement des esthétiques et des formes d’expressions –, cette enquête compile les
propos de six créateurs et artistes sonores de trois générations distinctes qui ont vécu ce
contexte : Monique Jean et Jean-François Laporte (génération 1960), Patrick Saint-Denis et
Cléo Palacio-Quintin (génération 1970), Adam Basanta et Émilie Payeur (génération 1980).
Chacun se prononce sur quatre thématiques principales : la définition de leur pratique
artistique, leurs réflexions sur la pluridisciplinarité ou la polyvalence, la perception de
l’environnement artistique entre leurs débuts et aujourd’hui, et leur rapport à
l’enseignement institutionnel versus l’apprentissage en autodidacte. Les réponses mettent en
lumière la diversité des perceptions alimentant la diversité des pratiques, les sensibilités
du contexte propres à chaque génération, ainsi que des visions personnelles de la ville
quant à ses institutions et activités artistiques.
Modernist Ultimate Thule
Authors: Windsor Liscombe Rhodri 
Published: May 2020

À partir de la Seconde Guerre mondiale, le gouvernement fédéral canadien s’est de plus en plus intéressé à ses régions nordiques et arctiques, au « pays du nord, puissant et libre », imaginé dans le texte anglais de l’hymne national du Canada. Ces terres lointaines ont fourni les ressources minérales nécessaires à certaines opérations militaires et ont servi de sites à des installations stratégiques. Le développement de nouvelles infrastructures comme l’Alaska Highway – traversant davantage le territoire canadien qu’américain – a également exposé la précarité de l’autonomie canadienne. Les stratégies pour la canadianisation du nord ont été renforcées par la guerre froide et les politiques de développement, surtout sous le régime Diefenbaker. Des architectes comme Peter Dickinson et Ralph Erskine ont été invités à préparer les plans de nouvelles colonies, notamment Frobisher Bay (1958) et Resolute (1963), où l’on a déployé une technologie de construction de pointe à partir d’objectifs de planification issus du mouvement moderne. Cet épisode illustre la collusion ironique entre le mouvement moderne et les moteurs de la modernité que celui-ci avait l’intention de reformuler.
Broiler Value Chain: Socioeconomic Plan for Commercial Broiler Farm in Jordan
Authors: Alhammd Zainab 
Published: May 2020

The broiler farm will be established in Bereen which is located in Zarqa Governorate and it is far away about 17 km from the capital Amman. Nearness of the farm to the city make easy access to market for the purchase of day old chicks, farm inputs (feed, etc.) and selling of broilers.
The farm is distant from the community, has good infrastructure such as roads, electricity and water.
With a vision to be a unique model for poultry production. The Mission of this study is to satisfy customers with consistent quality poultry products and services. Profitability and growth will be achieved through efficient production, human animal treatment and employee development in a safe and supportive work environment. Through making a substantial contribution to the economic and social development of the region through employment, supply quality and safety broiler meat in the region, making profitable enterprise to earn a good income.
The controlled poultry farm is a project of livestock sector, the purpose of the controlled poultry farm is to provide all the facilities ranging from automatic operations of temperature control, feeding and nipple drinking system for the broiler birds, monitored by the concerned & technical staff. Broiler farming in a controlled environment is a profitable venture due to continuously increasing demand of the white meat in the market. Poultry is an important sub-sector of agriculture that has contributed enormously to food production by playing a vital role in the domestic economy. The initial cost of the project is including of initial working capital of 417,797 JD, revenue and NR with a mortality rate not more than 5% is 29038 JD, the innovation in this project is a biogas unit to reach sustainability goals.
Water Logging in South-Western Coastal Region of Bangladesh: Causes and Consequences and People’s Response
Authors: Awal M. A. , Islam A. F. M. Tariqul 
Published: May 2020

Aim: Since decades, a major part of south-western coastal region of Bangladesh is being affected by water logging – a problem related to climate change along with some manmade activities. Therefore, the study was conducted to assess the causes and consequences of this problem and highlights the responses of affected people to attract policy planners’ intention for taking proper intervention.
Place and Duration of Study: The study was conducted in the Laboratory of Plant Ecology, Department of Crop Botany, Bangladesh Agricultural University, Mymensingh, Bangladesh.
Methodology: Qualitative and quantitative techniques have been applied to collect and analyze both the primary and secondary sources of data from various waterlogged areas of south west Bangladesh.
Results: There is no single or a few factors are responsible for creating water-logging problem rather it is a combination of several factors and their cumulative effects over time. It is revealed from the analysis of primary and secondary sources of information that death of Mathavanga River in the 20th century, execution of Coastal Embankment Project since 1960’s, withdrawing water flow to the Padma River through operating the Farakka barrage after independent of Bangladesh, improper management of rivers, faulty land-use by influential people in the areas, monsoon downpour etc are major causes of the problem. The silted up river systems in area could not drain monsoon rain that occurred even for a couple of days. The consequences brought to inundate hundred thousand hectares of cultivable land unsuitable for crop production. More than one million people are directly affected in the areas and the number is gradually increasing over the years. Water stagnancy around the settlement areas remains 6 to 9 months in a year and many places became permanently waterlogged. The affected people have no other way out but to live with water. The congested water is polluted with salinity, chemical effluents with heavy metals, household debris’s and related other pollutants. Source of safe drinking water is destroyed. Therefore incidences of waterborne and skin diseases are increased. People are living with greatest inhumanity as food, shelter, sanitation, communications, educations and other prime needs are tremendously challenged. Many people lost their occupations and became destitute, some altered their livelihood to much lower grades, and many of them are forced to migrate to city areas. The marooned people demanded to the authority to declare their places as an affected area and sought the government intervention to bring an end to the crisis through operating the Tidal River Management plan and excavating or re-excavating of associated rivers, channels and rivulets.
Conclusion: The authority need to pay keen attention to the issue and should take proper initiative to mitigate the water-logging problem permanently to save people living in the south western coastal region of Bangladesh.
Large‐Scale Patterning of Reactive Surfaces for Wearable and Environmentally Deployable Sensors
Authors: Matzeu Giusy , Mogas‐Soldevila Laia , Li Wenyi , Naidu Arin , Turner Trent H. , Gu Roger , Blumeris Patricia R. , Song Patrick , Pascal Daniel G. , Guidetti Giulia , Li Meng , Omenetto Fiorenzo G. 
Published: May 2020

AbstractWearable interfaces are central to multiple healthcare and wellness strategies encompassing diet and nutrition, personalized health monitoring, and performance optimization. Specifically, the advent of flexible electronic formats coupled with microfluidic interfaces has resulted in sophisticated conformal devices for biofluid sampling and quantification. Here, a complementary approach is presented to wearable sensing by using a large‐scale, conformal, distributed format that relies on the use of biomaterial‐based inks to print and stabilize deterministic patterns of biochemical reporters with high resolution. Colorimetric devices can vary in size and a sensing T‐shirt based on a colorimetric pattern is developed to illustrate the utility that such formats can add to the wearable interface space. Image analysis allows parameter variation to be tracked in real‐time, yielding a map‐like format of distributed biophysical response.
Assembly of Foldable 3D Microstructures Using Graphene Hinges
Authors: Lim Seungyun , Luan Haiwen , Zhao Shiwei , Lee Yongjun , Zhang Yihui , Huang Yonggang , Rogers John A. , Ahn Jong‐Hyun 
Published: May 2020

AbstractOrigami/kirigami‐inspired 3D assembly approaches have recently attracted attention for a variety of applications, such as advanced optoelectronic devices and biomedical sensors. The results reported here describe an approach to construct classes of multiple foldable 3D microstructures that involve deformations that typical conductive materials, such as conventional metal films, cannot tolerate. Atomically thin graphene sheets serve as folding hinges during a process of 2D to 3D conversion via a deterministic buckling process. The exceptional mechanical properties of graphene enable the controlled, geometric transformation of a 2D precursor bonded at selective sites on a prestretched elastomer into folded 3D microstructures, in a reversible manner without adverse effects on the electrical properties. Experimental and computational investigations of the folding mechanisms for such types of 3D objects reveal the underlying physics and the dependence of the process on the thickness of the graphene/supporting films that define the hinges.
Highly Thermotolerant Metal Halide Perovskite Solids
Authors: Lian Huiwang , Li Yang , Sharafudeen Kaniyarakkal , Zhao Weiren , Krishnan Gopi R. , Zhang Shaoan , Qiu Jianrong , Huang Kai , Han Gang 
Published: May 2020

AbstractBy virtue of their narrow emission bands, near‐unity quantum yield, and low fabrication cost, metal halide perovskites hold great promise in numerous aspects of optoelectronic applications, including solid‐state lighting, lasing, and displays. Despite such promise, the poor temperature tolerance and suboptimal quantum yield of the existing metal halide perovskites in their solid state have severely limited their practical applications. Here, a straightforward heterogeneous interfacial method to develop superior thermotolerant and highly emissive solid‐state metal halide perovskites is reported and their use as long‐lasting high‐temperature and high‐input‐power durable solid‐state light‐emitting diodes is illustrated. It is found that the resultant materials can well maintain their superior quantum efficiency after heating at a temperature over 150 °C for up to 22 h. A white light‐emitting diode (w‐LED) constructed from the metal halide perovskite solid exhibits superior temperature sustainable lifetime over 1100 h. The w‐LED also displays a highly durable high‐power‐driving capability, and its working current can go up to 300 mA. It is believed that such highly thermotolerant metal halide perovskites will unleash the possibility of a wide variety of high‐power and high‐temperature solid‐state lighting, lasing, and display devices that have been limited by existing methods.
Guest‐Tunable Dielectric Sensing Using a Single Crystal of HKUST‐1
Authors: Babal Arun S. , Chaudhari Abhijeet K. , Yeung Hamish H.‐M. , Tan Jin‐Chong 
Published: May 2020

AbstractThere is rising interest on low‐k dielectric materials based on porous metal–organic frameworks (MOFs) for improved electrical insulation in microelectronics. Herein, the concept of MOF dielectric sensor built from a single crystal of HKUST‐1 is demonstrated. Guest encapsulation effects of polar and non‐polar molecules are studied, by monitoring the transient dielectric response and AC conductivity of the crystal exposed to different vapors (water, iodine, methanol, and ethanol). The dielectric properties are measured along the <100> crystal direction in the frequency range of 100 Hz to 2 MHz. The dielectric data show the efficacy of MOF dielectric sensor for discriminating the guest analytes. The time‐dependent transient response reveals dynamics of the molecular inclusion and exclusion processes in the nanoscale pores. Since dielectric response is ubiquitous to all MOF materials (unlike DC conductivity and fluorescence), the results demonstrate the potential of dielectric MOF sensors compared to resistive sensors and luminescence‐based approaches.
Direct Catalytic Functionalization of Indazole Derivatives
Authors: Ghosh Sumit , Mondal Susmita , Hajra Alakananda 
Published: May 2020

AbstractIndazoles are a very important class of N‐containing heterocycles with a wide range of biological and medicinal properties. The presence of different functionalities on indazole moieties enhances its biological activities. Hence, the preparation of indazole compounds bearing functional groups has gained a significant interest to the organic synthetic chemists. A large effort has been made to develop efficient and new methods for the functionalization of indazoles. Direct catalytic functionalization is a very powerful tool for facile synthesis of important indazole derivatives due to its straightforwardness. This review summarizes developments on direct functionalizations of indazoles published in the last two decades.magnified image
A Loop‐Based and AGO‐Incorporated Virtual Screening Model Targeting AGO‐Mediated miRNA–mRNA Interactions for Drug Discovery to Rescue Bone Phenotype in Genetically Modified Mice
Authors: Zhuo Zhenjian , Wan Youyang , Guan Daogang , Ni Shuaijian , Wang Luyao , Zhang Zongkang , Liu Jin , Liang Chao , Yu Yuanyuan , Lu Aiping , Zhang Ge , Zhang Bao‐Ting 
Published: May 2020

AbstractSeveral virtual screening models are proposed to screen small molecules only targeting primary miRNAs without selectivity. Few attempts have been made to develop virtual screening strategies for discovering small molecules targeting mature miRNAs. Mature miRNAs and their specific target mRNA can form unique functional loops during argonaute (AGO)‐mediated miRNA–mRNA interactions, which may serve as potential targets for small‐molecule drug discovery. Thus, a loop‐based and AGO‐incorporated virtual screening model is constructed for targeting the loops. The previously published studies have found that miR‐214 can target ATF4 to inhibit osteoblastic bone formation, whereas miR‐214 can target TRAF3 to promote osteoclast activity. By using the virtual model, the top ten candidate small molecules targeting miR‐214‐ATF4 mRNA interactions and top ten candidate small molecules targeting miR‐214‐TRAF3 mRNA interactions are selected, respectively. Based on both in vitro and in vivo data, one small molecule can target miR‐214‐ATF4 mRNA to promote ATF4 protein expression and enhance osteogenic potential, whereas one small molecule can target miR‐214‐TRAF3 mRNA to promote TRAF3 protein expression and inhibit osteoclast activity. These data indicate that the loop‐based and AGO‐incorporated virtual screening model can help to obtain small molecules specifically targeting miRNA–mRNA interactions to rescue bone phenotype in genetically modified mice.