bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social determinants of violence against women in Panama: results from population-based cross-sectional studies and a femicide registry
Authors: Santamaría Ana , Gerald Carmen , Chamorro Fermina , Herrera Víctor , Flores Haydee , Sandoval Iris , Gómez Beatriz , Harbar Eyra , Liriola Leoteau , de León Richardson Ruth G , Motta Jorge , Moreno Velásquez Ilais 
Published: November 2019

Abstract

Background
We aimed to investigate the prevalence of violence against women (VAW) in Panama and its association with social determinants of health (SDH) and to estimate the femicide rates from 2014 to 2017.

Methods
Data were derived from three cross-sectional population-based studies. Logistic regression models were used to estimate the association between SDH and VAW, expressed as odds ratios (ORs) and 95% confidence intervals (CIs). Age-standardized femicide rates were estimated using data from the Public Ministry.

Results
Compared to the reference categories, women in the lowest quintile (Q) of income distribution (Q1: OR 4.0 [95% CI 1.4–11.7], Q2: OR 3.0 [95% CI 1.1–7.9]), divorced/separated women (OR 1.5 [95% CI 1.0–2.1]) and those in the age categories 25–33 y and 34–49 y (OR 1.9 [95% CI 1.2–3.1]) were more likely to have experienced violence in the past year. Indigenous ethnicity (OR 2.3 [95% CI 1.3–4.1]), age 15–19 y (OR 1.8 [95% CI 1.1–2.9]) and lowest education levels (very low: OR 4.7 [95% CI 1.4–15.5]; low: OR 4.5 [95% CI 1.4–14.6]) were associated with permissive attitudes towards violence. Indigenous (OR 2.7 [95% CI 1.3–6.1]), Afro-Panamanians (OR 3.1 [95% CI 1.3–7.6]) and education level (low: OR 2.5 [95% CI 1.2–4.9]; medium: OR 3.0 [95% CI 1.4–6.6]) were associated with physical/sexual intimate partner violence. Standardized adjusted femicide rates (×100 000) from 2015 to 2017 were 1.5, 0.9 and 0.8, respectively.

Conclusions
Our findings highlight the importance of prevention programmes.
Case Report: Synthetic Cannabinoid Deaths in State of Florida Prisoners
Authors: Hvozdovich Jessica A , Chronister Chris W , Logan Barry K , Goldberger Bruce A 
Published: November 2019

Abstract
Between March 2017 and November 2018, 54 prisoner fatal overdose cases submitted to the University of Florida Forensic Toxicology Laboratory involved synthetic cannabinoids including 5F-ADB, FUB-AMB, 5F-AMB, MDMB-FUBINACA and AB-CHMINACA. Analysis of blood and urine samples was performed at NMS Labs (Horsham, PA) by liquid chromatography/tandem mass spectrometry screening, confirmatory and quantitative methods validated according to Scientific Working Group for Forensic Toxicology guidelines. This work highlights the importance of effective communication between toxicologists and medical examiners/coroners, and the value of public-private partnerships to provide coverage while laboratories work to update instrumentation and validate their own new methods to keep up with the challenges of emerging substances.
A new genus and species of parasitic isopod (Bopyroidea: Entoniscidae) infesting pinnotherid crabs (Brachyura: Pinnotheridae) on the Atlantic coast of the USA, with notes on the life cycle of entoniscids
Authors: McDermott John J , Williams Jason D , Boyko Christopher B 
Published: November 2019

AbstractPinnixion sexdecennia n. gen., n. sp. is described from three pinnotherid hosts: Austinixa gorei (Manning & Felder, 1989), Pinnixa chaetopterana Stimpson, 1860, and Zaops ostreus (Say, 1817). Females of the new species are distinguished from all other entoniscids by possessing two transverse lobes on oostegite 1 and fused oostegites 2–5; males have a pair of lateral expansions on each of the first two pleomeres. The epicaridium larvae of the new species also have a unique elongated, cylindrical terminal process on the pereopod 6 dactylus. Pinnixion sexdecennian. gen., n. sp. exhibited highest prevalence (&gt; 40%) in North Carolina and Florida. Examination of live specimens of P. chaetopterana infested with mature female isopods showed that larvae are liberated via a pore produced in the wall of the host’s branchial chamber. Mature females of P. sexdecennian. gen., n. sp. occupied nearly all available space within the host crab’s hemocoel. Female P. chaetopterana had higher prevalence than males, and intensities of infestations were also greater in females. Evidence from all locations showed that mature parasites do not inhibit breeding or molting in the host. Our report is one of the few studies on the ecology and biology of entoniscids, a cryptic but ecologically important group of parasitic isopods. We also resolve long-standing nomenclatural issues involving Entione Kossmann, 1881 and Entioninae Codreanu, Codreanu & Pike, 1960, the subfamily to which the new genus and species belongs, by synonymizing Grapsion Giard & Bonnier, 1886 with Entione.
Estimates of growth and longevity of six species of freshwater shrimps (Macrobrachium spp.) (Decapoda: Caridea: Palaemonidae) from Costa Rica
Authors: Ibarra Mauricio A , Wehrtmann Ingo S 
Published: November 2019

AbstractInformation about growth is of particular relevance for stock assessment and management as well as for evaluating the aquaculture potential of any decapod species, but this information is lacking for the Central American species of MacrobrachiumSpence Bate, 1868. We collected specimens of six species of Macrobrachium monthly (February 2006 to August 2008) along the Pacific slope of Costa Rica. The collected individuals were sexed and weighted, and total length (TL) and carapace length (CL) were measured. The von Bertalanffy growth model was fitted to the data by applying the maximum likelihood method. The species analyzed reaching theoretically the largest sizes were M. americanum (Spence Bate, 1868), M. tenellum (Smith, 1871), and M. panamenseRathbun, 1912. With few exceptions, maximum sizes of all species were generally higher than those published in previous reports, suggesting that environmental conditions are favorable and anthropogenic impacts may be less severe in Costa Rica than in other countries. Only M. americanum exceeded the asymptotic total length estimates of other species, corroborating that this species is considered as one of the largest congeners worldwide. Estimated maximum age ranged from 3.9 (M. occidentaleHolthuis, 1950) to 11.5 yrs (M. tenellum). All six Macrobrachium species showed a positive allometric growth type. The model describing the length-weight relationship was statistically significant (P &lt; 0.05) for all species. Although the maximum likelihood method has been applied so far mainly to compare different growth models, here we used this method to generate the first growth estimates for the six species from Costa Rica, and future studies might use this method to compare growth patterns among different species.
Frequency-domain magnetotelluric footprint analysis for 3D earths
Authors: Wang Yongfei , Liu Jianxin , Liu Rong , Guo Rongwen , Feng Deshan 
Published: November 2019

AbstractFor magnetotelluric (MT) data with a large coverage, inversion interpretation for the whole area is usually impossible, due to the physical limitation of a computer. However, for each MT station, it is only sensitive to a region (called MT footprint) localized immediately underneath the station, much smaller than the whole survey area. Thus the whole large survey area can be subdivided into many sub-areas and inverted using the moving footprint technique efficiently. Therefore, to understand the MT footprint is of great importance for developing such an inversion algorithm. In this paper, we study the influence of frequency, resistivity and existence of anomalous structure in the MT footprint. We first use the finite difference method to evaluate the total electromagnetic (EM) fields, then apply the numerical volume integration of tensor green's function to calculate the total induced fields at the receiver (summation of the contribution for each cell). The footprint is obtained based on the contribution of each cell to the total induced fields. Different models are designed to understand the footprint for MT problems. An increase in frequency or conductivity results in a decrease in the size of footprint. Existence of anomalous bodies within the footprint affects the MT footprint size to a degree, dependent on the overall resistivity. Outside the footprint, the existence of anomalous bodies have little effect on the footprint size and shape.
Antihistamines and Ovarian Cancer Survival: Nationwide Cohort Study and in Vitro Cell Viability Assay
Authors: Verdoodt Freija , Dehlendorff Christian , Jäättelä Marja , Strauss Robert , Pottegård Anton , Hallas Jesper , Friis Søren , Kjaer Susanne K 
Published: November 2019

Abstract
Antihistamines with cationic amphiphilic drug (CAD) characteristics induce cancer-specific cell death in experimental studies. Epidemiologic evidence is, however, limited. In a Danish nationwide cohort of ovarian cancer patients diagnosed during 2000–2015 (n = 5075), we evaluated the association between filled antihistamine prescriptions and cancer mortality. We used Cox regression models to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for ovarian cancer mortality. In an in vitro cell viability assay, we evaluated cell death in three ovarian cancer cell lines after treatment with clinically relevant doses of eight antihistamines. In our cohort study, CAD antihistamine use (≥1 prescription; n = 133) was associated with a hazard ratio of 0.63 (95% CI = 0.40 to 0.99) compared to use of non-CAD antihistamines (n = 304), and we found a tendency toward a dose-response association. In our cell viability assay, we found consistent and dose-dependent cytotoxicity for all CAD but not non-CAD antihistamines. In this nationwide cohort study, use of antihistamines with CAD characteristics is associated with a prognostic benefit in ovarian cancer patients.
Prostate Cancer Outcomes Following Solid-Organ Transplantation: A SEER-Medicare Analysis
Authors: Liauw Stanley L , Ham Sandra A , Das Lauren C , Rudra Sonali , Packiam Vignesh T , Koshy Matthew , Weichselbaum Ralph R , Becker Yolanda T , Bodzin Adam S , Eggener Scott E 
Published: November 2019

Abstract

Background
Immunosuppressive regimens associated with organ transplantation increase the risk of developing cancer. Transplant candidates and recipients with prostate cancer are often treated, even if low-risk features would ordinarily justify active surveillance.

Methods
Using SEER-Medicare, we identified 163 676 men aged 66 years and older diagnosed with nonmetastatic prostate cancer. History of solid organ transplant was identified using diagnosis or procedure codes. A propensity score-matched cohort was identified by matching transplanted men to nontransplanted controls by age, race, region, year, T-stage, grade, comorbidity, and cancer therapy. Fine-Gray competing risk models assessed associations between transplant status and prostate cancer-specific mortality (PCSM) and overall mortality (OM).

Results
We identified 620 men (0.4%) with transplant up to 10 years before (n = 320) or 5 years after (n = 300) prostate cancer diagnosis and matched them to 3100 men. At 10 years, OM was 55.7% and PCSM was 6.0% in the transplant cohort compared with 42.4% (P &lt; .001) and 7.6% (P = .70) in the nontransplant cohort, respectively. Adjusted models showed no difference in PCSM for transplanted men (hazard ratio = 0.88, 95% confidence interval = 0.61 to 1.27, P = .70) or differences by prostate cancer therapy. Among 334 transplanted men with T1-2N0, well or moderately differentiated “low-risk” prostate cancer, PCSM was similar for treated and untreated men (hazard ratio = 0.92, 95% confidence interval = 0.47 to 1.81).

Conclusions
Among men aged 66 years and older with prostate cancer, an organ transplant is associated with higher OM but no observable difference in PCSM. These findings suggest men with prostate cancer and previous or future organ transplantation should be managed per usual standards of care, including consideration of active surveillance for low-risk cancer characteristics.
Japanese Encephalitis Virus Infects the Thalamus Early Followed by Sensory-Associated Cortex and Other Parts of the Central and Peripheral Nervous Systems
Authors: Fu Tzeh Long , Ong Kien Chai , Tan Soon Hao , Wong Kum Thong 
Published: November 2019

AbstractJapanese encephalitis (JE) is a known CNS viral infection that often involves the thalamus early. To investigate the possible role of sensory peripheral nervous system (PNS) in early neuroinvasion, we developed a left hindlimb footpad-inoculation mouse model to recapitulate human infection by a mosquito bite. A 1–5 days postinfection (dpi) study, demonstrated focal viral antigens/RNA in contralateral thalamic neurons at 3 dpi in 50% of the animals. From 4 to 5 dpi, gradual increase in viral antigens/RNA was observed in bilateral thalami, somatosensory, and piriform cortices, and then the entire CNS. Infection of neuronal bodies and adjacent nerves in dorsal root ganglia (DRGs), trigeminal ganglia, and autonomic ganglia (intestine, etc.) was also observed from 5 dpi. Infection of explant organotypic whole brain slice cultures demonstrated no viral predilection for the thalamus, while DRG and intestinal ganglia organotypic cultures confirmed sensory and autonomic ganglia susceptibility to infection, respectively. Early thalamus and sensory-associated cortex involvement suggest an important role for sensory pathways in neuroinvasion. Our results suggest that JE virus neuronotropism is much more extensive than previously known, and that the sensory PNS and autonomic system are susceptible to infection.
Giant plexiform schwannoma in the plantar aspect of the foot: a case report
Authors: Matsuoka Yuki , Kakudo Natsuko , Fukui Michika , Kusumoto Kenji 
Published: November 2019

Abstract
Plexiform schwannoma is a rare Schwann cell tumor that usually occurs in the head and neck. Here, we report a giant plexiform schwannoma (5.5 × 4.0 cm) in the right plantar aspect of the foot. This tumor presented from the dermis to the subcutaneous fat in the plantar aspect, forming a multiocular shape.
Storing carbon in leaf lipid sinks enhances perennial ryegrass carbon capture especially under high N and elevated CO2
Authors: Beechey-Gradwell Zac , Cooney Luke , Winichayakul Somrutai , Andrews Mitchell , Hea Shen Y , Crowther Tracey , Roberts Nick 
Published: November 2019

AbstractBy modifying two genes involved in lipid biosynthesis and storage [cysteine oleosin (cys-OLE)/diacylglycerol O-acyltransferase (DGAT)], the accumulation of stable lipid droplets in perennial ryegrass (Lolium perenne) leaves was achieved. Growth, biomass allocation, leaf structure, gas exchange parameters, fatty acids, and water-soluble carbohydrates were quantified for a high-expressing cys-OLE/DGAT ryegrass transformant (HL) and a wild-type (WT) control grown under controlled conditions with 1–10 mM nitrogen (N) supply at ambient and elevated atmospheric CO2. A dramatic shift in leaf carbon (C) storage occurred in HL leaves, away from readily mobilizable carbohydrates and towards stable lipid droplets. HL exhibited an increased growth rate, mainly in non-photosynthetic organs, leading to a decreased leaf mass fraction. HL leaves, however, displayed an increased specific leaf area and photosynthetic rate per unit leaf area, delivering greater overall C capture and leaf growth at high N supply. HL also exhibited a greater photosynthesis response to elevated atmospheric CO2. We speculate that by behaving as uniquely stable microsinks for C, cys-OLE-encapsulated lipid droplets can reduce feedback inhibition of photosynthesis and drive greater C capture. Manipulation of many genes and gene combinations has been used to increase non-seed lipid content. However, the cys-OLE/DGAT technology remains the only reported case that increases plant biomass. We contrast cys-OLE/DGAT with other lipid accumulation strategies and discuss the implications of introducing lipid sinks into non-seed organs for plant energy homeostasis and growth.
Investigating a unique partial eclipse in the high-mass X-ray binary IGR J16393−4643 with Swift-XRT
Authors: Kabiraj Sanhita , Islam Nazma , Paul Biswajit 
Published: November 2019

ABSTRACT
The orbital profile of the high-mass X-ray binary IGR J16393−4643 shows a dip in its X-ray intensity, which was previously interpreted as an eclipse. Unlike most eclipsing HMXBs, where the X-ray eclipses are about two orders of magnitude fainter compared to the out-of-eclipse emission, this particular eclipse-like feature is narrow and partial, casting doubt if it is indeed an eclipse. To further investigate the nature of this low-intensity orbital phase, we use a large number of observations with Swift-XRT, covering the entire orbital phase. The soft X-ray observations also show this low-intensity phase, which is about 30 % of the intensity during rest of the orbit. We also carried out orbital-phase-resolved spectroscopy to compare the change in the spectral parameters inside and outside of this low-intensity state. The results indicate that this low-intensity state might not be an eclipse, as previously thought but absorption in the stellar corona. We have also provided the inclination angle of the binary for grazing eclipse caused by the stellar corona.
Statistical properties of magnetar bursts and FRB 121102
Authors: Cheng Yingjie , Zhang G Q , Wang F Y 
Published: November 2019

ABSTRACT
In this paper, we present statistics of soft gamma repeater (SGR) bursts from SGR J1550−5418, SGR 1806−20, and SGR 1900+14 by adding new bursts from Kırmızıbayrak et al. detected with the Rossi X-ray Timing Explorer. We find that the fluence distributions of magnetar bursts are well described by power-law functions with indices 1.84, 1.68, and 1.65 for SGR J1550−5418, SGR 1806−20, and SGR 1900+14, respectively. The duration distributions of magnetar bursts also show power-law forms. Meanwhile, the waiting time distribution can be described by a non-stationary Poisson process with an exponentially growing occurrence rate. These distributive features indicate that magnetar bursts can be regarded as a self-organizing critical process. We also compare these distributions with the repeating fast radio burst (FRB) 121102. The statistical properties of repeating FRB 121102 are similar with magnetar bursts, combining with the large required magnetic field (B ≥ 1014 G) of neutron star for FRB 121102, which indicates that the central engine of FRB 121102 may be a magnetar.
Outflows from inflows: the nature of Bondi-like accretion
Authors: Waters Tim , Aykutalp Aycin , Proga Daniel , Johnson Jarrett , Li Hui , Smidt Joseph 
Published: November 2019

ABSTRACT
The classic Bondi solution remains a common starting point both for studying black hole growth across cosmic time in cosmological simulations and for smaller scale simulations of active galactic nuclei (AGN) feedback. In nature, however, there will be inhomogeneous distributions of rotational velocity and density along the outer radius (Ro) marking the sphere of influence of a black hole. While there have been many studies of how the Bondi solution changes with a prescribed angular momentum boundary condition, they have all assumed a constant density at Ro. In this Letter, we show that a non-uniform density at Ro causes a meridional flow and due to conservation of angular momentum, the Bondi solution qualitatively changes into an inflow–outflow solution. Using physical arguments, we analytically identify the critical logarithmic density gradient |$\partial \ln \rho/\partial \theta$| above which this change of the solution occurs. For realistic Ro, this critical gradient is less than 0.01 and tends to 0 as Ro → ∞. We show using numerical simulations that, unlike for solutions with an imposed rotational velocity, the accretion rate for solutions under an inhomogeneous density boundary condition remains constant at nearly the Bondi rate $\dot{M}_\mathrm{ B}$, while the outflow rate can greatly exceed $\dot{M}_\mathrm{ B}$.
Promises and Perils of Artificial Intelligence in Neurosurgery
Authors: Panesar Sandip S , Kliot Michel , Parrish Rob , Fernandez-Miranda Juan , Cagle Yvonne , Britz Gavin W 
Published: November 2019

Abstract
Artificial intelligence (AI)-facilitated clinical automation is expected to become increasingly prevalent in the near future. AI techniques may permit rapid and detailed analysis of the large quantities of clinical data generated in modern healthcare settings, at a level that is otherwise impossible by humans. Subsequently, AI may enhance clinical practice by pushing the limits of diagnostics, clinical decision making, and prognostication. Moreover, if combined with surgical robotics and other surgical adjuncts such as image guidance, AI may find its way into the operating room and permit more accurate interventions, with fewer errors. Despite the considerable hype surrounding the impending medical AI revolution, little has been written about potential downsides to increasing clinical automation. These may include both direct and indirect consequences. Directly, faulty, inadequately trained, or poorly understood algorithms may produce erroneous results, which may have wide-scale impact. Indirectly, increasing use of automation may exacerbate de-skilling of human physicians due to over-reliance, poor understanding, overconfidence, and lack of necessary vigilance of an automated clinical workflow. Many of these negative phenomena have already been witnessed in other industries that have already undergone, or are undergoing “automation revolutions,” namely commercial aviation and the automotive industry. This narrative review explores the potential benefits and consequences of the anticipated medical AI revolution from a neurosurgical perspective.
Diagnosis and Management of Osteomyelitis Associated With Stage 4 Pressure Ulcers: Report of a Query to the Emerging Infections Network of the Infectious Diseases Society of America
Authors: Kaka Anjum S , Beekmann Susan E , Gravely Amy , Filice Gregory A , Polgreen Philip M , Johnson James R 
Published: November 2019

AbstractBackgroundFew studies exist to guide the management of patients with stage 4 pressure ulcers with possible underlying osteomyelitis. We hypothesized that infectious disease (ID) physicians would vary widely in their approach to such patients.MethodsThe Emerging Infections Network distributed a 10-question electronic survey in 2018 to 1332 adult ID physicians in different practice settings to determine their approach to such patients.ResultsOf the 558 respondents (response rate: 42%), 17% had managed no such patient in the past year. Of the remaining 464 respondents, 60% usually felt confident in diagnosing osteomyelitis; the strongest clinical indicator of osteomyelitis reported was palpable or visible bone at the ulcer base. Approaches to diagnosing osteomyelitis in patients with visible and palpable bone varied: 41% of respondents would assume osteomyelitis, 27% would attempt pressure off-loading first, and 22% would perform diagnostic testing immediately. Preferred tests for osteomyelitis were bone biopsy (for culture and histopathology) and magnetic resonance imaging. Respondents differed widely on favored route(s) (intravenous, oral, or both) and duration of antimicrobial therapy but would treat longer in the absence, vs presence, of full surgical debridement (P < .001). Overall, 62% of respondents opined that osteomyelitis under stage 4 pressure ulcers is usually or almost always treated excessively, and most (59%) suggested multiple topics for future research.ConclusionsRegarding osteomyelitis underlying stage 4 pressure ulcers, ID physicians reported widely divergent diagnostic and treatment approaches. Most of the reported practice is not supported by the available evidence, which is quite limited and of low quality.