bluuebunny/crossref_metadata_2025_split huggingface dataset:
FDG-PET/CT Radiomics Models for The Early Prediction of Locoregional Recurrence in Head and Neck Cancer
Authors: Cong Hu , Peng Wang , Tian Zhou , Vallières Martin , Chuanpei Xu , Aijun Zhu , Benxin Zhang 
Published: July 2020

Purpose:
Both CT and PET radiomics is considered as a potential prognostic biomarker
in head and neck cancer. This study investigates the value of fused pre-treatment functional imaging
(18F-FDG PET/CT) radiomics for modeling of local recurrence of head and neck cancers.

Material and Methods:
Firstly, 298 patients have been divided into a training set (n = 192) and
verification set (n = 106). Secondly, PETs and CTs are fused based on wavelet transform. Thirdly,
radiomics features are extracted from the 3D tumor area from PETCT fusion. The training set is
used to select the features reduction and predict local recurrence, and the random forest prediction
models combining radiomics and clinical variables are constructed. Finally, the ROC curve and KM
analysis are used to evaluate the prediction efficiency of the model on the validation set.

Results:
Two PET/CT fusion radiomics features and three clinic parameters are extracted to construct
the radiomics model. AUC value in the verification set 0.70 is better than no fused sets 0.69.
The accuracy of 0.66 is not the highest value (0.67). Either consistency index CI 0.70 (from 0.67 to
0.70) or the p-value 0.025 (from 0.03 to 0.025) get the best result in all four models.

Conclusion:
The radiomics model based on the fusion of PETCT is better than the model based on
PET or CT alone in predicting local recurrence, the inclusion of clinical parameters may result in
more accurate predictions, which has certain guiding significance for the development of personalized,
precise treatment scheme.
Structure Prediction of SPAK C-terminal Domain and Analysis of its Binding to RFXV/I Motifs by Homology Modelling, Docking and Molecular Dynamics Simulation Studies
Authors: Alamri Mubarak A. , Alafnan Ahmed D. , Afzal Obaid , Alabbas Alhumaidi B. , Alqahtani Safar M. 
Published: July 2020

Background:
The STE20/SPS1-related proline/alanine-rich kinase (SPAK) is a component
of WNK-SPAK/OSR1 signaling pathway that plays an essential role in blood pressure regulation.
The function of SPAK is mediated by its highly conserved C-terminal domain (CTD) that interacts
with RFXV/I motifs of upstream activators, WNK kinases, and downstream substrate, cation-
chloride cotransporters.

Objective:
To determine and validate the three-dimensional structure of the CTD of SPAK and to study and analyze its
interaction with the RFXV/I motifs.

Methods:
A homology model of SPAK CTD was generated and validated through multiple approaches.
The model was based on utilizing the OSR1 protein kinase as a template. This model was
subjected to a 100 ns molecular dynamic (MD) simulation to evaluate its dynamic stability. The final
equilibrated model was used to dock the RFQV-peptide derived from WNK4 into the primary
pocket that was determined based on the homology sequence between human SPAK and OSR1
CTDs. The mechanism of interaction, conformational rearrangement and dynamic stability of the
binding of RFQV-peptide to SPAK CTD were characterized by molecular docking and molecular
dynamic simulation.

Results:
The MD simulation suggested that the binding of RFQV induces a large conformational
change due to the distribution of salt bridge within the loop regions. These results may help in understanding
the relationship between the structure and function of SPAK CTD and to support the
drug design of potential SPAK kinase inhibitors as antihypertensive agents.

Conclusion:
This study provides deep insight into SPAK CTD structure and function relationship.
Antimicrobial Applications of Nanoliposome Encapsulated Silver Nanoparticles: A Potential Strategy to Overcome Bacterial Resistance
Authors: Mozafari M.R. , Torkaman Sarabanou , Karamouzian Fatemeh Mahsa , Rasti Babak , Baral Bikash 
Published: July 2020

Abstract:
Bacterial infections result in hundreds of million cases of severe illness annually worldwide.
Rapidly increasing drug resistance of pathogens further aggravates this threat to human health
and warrants the search for effective broad-spectrum antibacterial agents. Silver metal has a long
history of application in human medicine and healthcare. In ancient times, silver was employed as a
disinfectant for water purification and storage while it is still being used as an antimicrobial ingredient
in some nanotechnology-based products. Encapsulation of antimicrobial substances such as silver
nanoparticles in nanoliposomes could provide protection and targeting for the encapsulated or entrapped
material. Nanoliposomes are biocompatible and biodegradable drug delivery systems with
the ability to encapsulate both lipid-soluble and water-soluble compounds, as well as metal ions.
Furthermore, nanoliposomes have been shown to be able to deliver encapsulated agents to target
bacteria in vitro as well as in vivo. In this review, we present the use of nanoliposome-encapsulated
silver nanoparticles as an efficient system for antibacterial applications.
Insight into Delivery Approaches for Biopharmaceutics Classification System Class II and IV Drugs
Authors: Chaturvedi Shashank , Mishra Raghav 
Published: July 2020

:
Formulation development of BCS Class II and IV drugs is a challenging task due to their
poor solubility and permeability issue.

:
An extensive literature survey was conducted to explore the relevant pharmaceutical approaches that
have been used for solving the issue of poor solubility and permeability in the recent past.

:
It has been found that a plethora of approaches have been investigated for addressing the issue of poor
solubility and or permeability. These include physical modifications (modification of crystal habit, particle
size reduction, complexation, polymorphism and drug dispersion in carriers), chemical modifications
(salt formation), and formulation modifications (Nanotechnology-based approaches and hydrotropy).

:
The physical and chemical modification approaches can be effectively used to enhance the solubility
and dissolution rate of poorly soluble drugs, but the additional problem of poor permeability has been
better addressed by lipid-based drug delivery systems. As the latter presents the drug in the solubilized
state, bypass first-pass effects, circumvent the effect of Para-glycoprotein mediated efflux of drugs,
hence contributing to overall bioavailability enhancement.
THE QUALITY OF FINANCIAL STATEMENTS ANTECEDENTS AND CONSEQUENCES TOWARDS FINANCIAL ACCOUNTABILITY
Authors: Karyatni Ni Made Dwi , Handajani Lilik 
Published: July 2020

Based on this research, low quality of financial statement presentation, especially regional government level accounting entity. Presentation of the financial statements of the Regional Government Unit was not fully appropriate with the Governmental Accounting Standards and Accounting Policies so that affects the accuracy of the information presented in the financial statements. Inaccurate financial reports has a negative impact to users in policy decision. This study aimed to test empirically the factors that affect the quality of the financial statements and the problems were faced by regional government unit (SKPD) in preparing the financial statements and the implications for the financial accountability. The population in this research was 292 respondents. The sample was determined by purposive sampling technique amount 97 respondents including the Financial Administration Officer (PPK) SKPD, PPK staff at 44 SKPD staff and staff in accounting staff and reporting on SKPKD. Data analysis was used on Partial Least Square (PLS). The findings of this study indicate that the quality of SKPD financial statements was affected by the application of completion of audit findings, but this study is not affected by the reconciliation, competence of human resources and the leadership support. Other findings indicate that the financial statements SKPD have implications for financial accountability. The implications of this study can contribute some ideas for the Central Lombok regency government to increase financial assistance to personnel managers through education and training so that it can make good quality in the financial statements and practical contribution in formulating the direction and policies related to the accountability of local government financial reporting.
An Analysis of University Students’ Perspective On Online Learning in The Midst of Covid-19 Pandemic
Authors: Sujarwo Sujarwo , Sukmawati Sukmawati , Akhiruddin Akhiruddin , Ridwan Ridwan , Suharti Siradjuddin Suharti Siradjuddin 
Published: July 2020

In this study we address and investigate university students’ perspective on utilizing online learning in the midst of COVID-19 pandemic. This research used qualitative descriptive method. The subject of this research were the learners of Elementary School Teacher Education, Physical Education, Sociology Education and English Education Department of Universitas Megarezky in 2019/2020 academic year. The number of respondents was 40 respondents. The research instruments were questionnaire that was obtained by google form through analyzing participants’ response to know their perspective in using online learning and in-depth interview. The study showed that previously, students did not use online learning before the pandemic because learning was conducted in the classroom. In the midst of covid-19 pandemic, the students are interested in using online learning in which can be accessed flexible, anywhere and everywhere. The best application used by lecturers and students was WhatsApp application. It can be concluded that the students’ perspective on online learning had a positive impact in the midst of the covid-19 pandemic.
Renal Cell Carcinoma (RCC) Stain Negative Metastatic Clear Cell Renal Cell Carcinoma Masquerading as a Pyogenic Granuloma on the Scalp
Authors: Vasile Gabriella Francesca , Levin Adam , Kleinfelder Raymond , Rivlin Daniel , Glick Brad 
Published: July 2020

Metastasis occurs in 25-50% of patients diagnosed with primary renal cell carcinoma (RCC), although only 6% of RCC metastases manifest on the skin. We present a unique case of a slowly growing clear cell RCC metastasis of the scalp in a middle-aged male that was RCC stain negative. The lesion clinically appeared to be a benign pyogenic granuloma, however, the diagnosis of metastatic clear cell renal cell carcinoma was made based on histology. Because cutaneous metastases may masquerade as other more benign tumors, the physician must be clinically suspicious of vascular appearing lesions on the scalp.
Photodynamic Therapy with δ-Aminolevulinic Acid and Blue Light for the Treatment of Actinic Cheilitis
Authors: Paul Joan , Dagrosa Alicia T. , Chen Youdinghuan , Gangar Pamela , Ressler Daniel , Chapman M. Shane 
Published: July 2020

ABSTRACTBackground: Actinic cheilitis is a common precancerous disorder of the lower lip caused by ultraviolet radiation. Photodynamic therapy (PDT) is a potential treatment for actinic cheilitis, however controlled clinical trials regarding this treatment are needed.Objective: To evaluate the safety and efficacy of PDT with blue light and topical δ-aminolevulinic acid (Levulan®) in the treatment of actinic cheilitis.Methods: We conducted a single center, investigator-initiated, nonrandomized, open-label, proof of concept study of PDT with blue light for the treatment of actinic cheilitis. We enrolled 24 subjects, 20 meeting inclusion and exclusion criteria. One subject withdrew from the study prior to treatment. The study consisted of a screening visit, one to three scheduled treatments, and two follow-up visits. The primary outcome was clinical improvement in actinic cheilitis from baseline, estimated as no (0%), mild (25%), moderate (50%), marked (75%), or excellent improvement (100%). Post-treatment assessment of swelling, erythema, flaking/scaling, crusting, vesiculation/pustulation, and erosion/ulceration was also recorded. Subjects completed the Dermatological Life Quality Index questionnaire, subject global assessment of improvement, and pain assessment at each visit.Results: 65% of subjects achieved clinical improvement of 75% or greater and 20% achieved 100% improvement by the end of the study. Treatments were well tolerated with minimal discomfort. Subjects experienced transient mild adverse effects.Conclusion: Overall, our study supports using PDT for the treatment of actinic cheilitis.
Aseptic Syphilitic Meningitis in an HIV-Negative Patient with Concomitant Primary and Secondary Syphilis
Authors: Jimenez Antonio Roberto , Hoyer Paige , Wilkerson Michael 
Published: July 2020

Background: Syphilis is a sexually and vertically transmitted disease caused by the Treponema pallidum species. Aseptic syphilitic meningitis (ASM) is a subcategory of neurosyphilis. Neurosyphilis is typically considered a tertiary manifestation of syphilis; however, ASM typically occurs within 6 months of exposure and may be concurrent with the rash of secondary syphilis. Case Presentation: A 58-year-old immunocompetent male presented to the dermatology clinic with an erythematous morbilliform rash that involved his trunk and upper extremities. He was prescribed benzonatate 100 mg 3 weeks prior for cough and was diagnosed with a drug-induced morbilliform rash. The patient was seen 1 month later by urology for a penile ulcer. At his urology appointment, an RPR test was done and resulted positive with a titer of 1:256. He was referred to dermatology again and was noted to have a diffuse, copper-colored maculopapular rash involving the palms and soles. During this appointment, the patient complained of a 4-week headache and was found to have nuchal rigidity. He was admitted for neurosyphilis work up, including CSF and CSF-VDRL examination. His neurologic symptoms improved on IV Penicillin G. Repeat RPR testing at 6 months follow up confirmed adequate treatment and his RPR declined from 1:256 to 1:4. Conclusion: We present a case of ASM in an immunocompetent individual with concomitant primary and secondary syphilis. Dermatologists are trained to recognize the cutaneous manifestations of syphilis, but also should be familiar with the variable presentations of the disease, including the early neurological findings of ASM.
Truncal Demodex Folliculitis
Authors: Orlowski Timothy Jay , Reynolds Hoyt Harris , Graham Lauren V 
Published: July 2020

Demodex brevis and Demodex folliculorum are two species of ubiquitous parasites whose role in human disease continues to be fully elucidated. Demodex most commonly causes symptomatic infestations confined to the head and neck. Clinically, symptoms may mimic acne vulgaris, papulopustular rosacea, perioral dermatitis, and seborrheic dermatitis, among others. Practitioners must maintain a high level of suspicion to avoid a misdiagnosis.
Considerations for Dermatologic Patient Care during COVID-19
Authors: Cockerell Clay J , Heibel Haley D , Workman Ashleigh 
Published: July 2020

The COVID-19 pandemic has led to numerous challenges in dermatology. Here, we discuss our experience of diagnosing multiple metastatic cutaneous cancers during the COVID-19 era and consider how perceived and existing barriers for patients receiving dermatologic care in the pandemic may have led to the progression of cancer. In Texas, the attorney general issued a statement that dermatologists could not perform “routine” procedures. Unfortunately, many dermatologists delayed biopsies and surgeries for skin cancer due to misinterpreting the ambiguous nature of the term “routine.” Dermatologists provide valuable expertise and crucial services to society at all times, including during life-threatening pandemics, and this should be emphasized to the public and governmental agencies.
Features of structure formation of surface layers with high content of boron on steel 15Х11МФ in the conditions of furnace and induction heating
Authors: Knyazev S.A. 
Published: July 2020

The results of obtaining borated layers on 15H11MF high-alloy steel under equilibrium and non-equilibrium heating conditions are presented. Equilibrium conditions were achieved by slow furnace heating (with a heating rate of 0.1 oC/s), non-equilibrium – by induction heating (with a heating rate of 100 oC/s). The heating was controlled by measuring the thermoelectric power by a thermocouple welded to the surface of the sample by electric contact welding. The signal from the thermocouple was digitized by the ADC and transmitted to a computer where, at high speed, an array of data of temperature-time dependence of the process was formed. Furnace heating was carried out in a laboratory electric furnace at 1130 оС ± 5 оС, 1150 оС ± 5 оС and 1160 оС ± 5 оС. Induction heating was carried out to temperatures of 1180 oC ± 20oC, 1200 oC ± 20oC, 1220 oC ± 20oC. The possibility of significant reduction of the treatment process from 3 hours to 2 minutes due to the intensifying action in non-equilibrium conditions of structure formation is shown. Boron saturation came from the paste. Saturating paste consisted of 60% boron carbide, 30% NaF, 10% CaF2. The method of metallographic research shows not only the morphological differences of the obtained surface layers, but also established the predominant mechanism of boron diffusion into high-alloy martensitic steel. During furnace heating (1150оС), a solid boron with a thickness of up to 50 μm and a hardness of 15100 MPa is formed. At a depth of up to 150 μm, grain boundary diffusion is noticeable, which obviously dominates in the processes of boron saturation of high-alloy steels. At temperatures of 1160 oC and furnace heating under a solid layer of boride with a thickness of 110 μm, a two-phase zone is formed, which consists of boride and a solid solution with a thickness of 70 μm. This layer is more defective. Induction heating with boron saturation forms a thick (up to 200 μm) layer of coarse boride crystallites (18900 – 9270 MPa) with an eutectic structure (6440 MPa), which becomes coarser with increasing temperature from 1180 to 1220 оС. The ability to obtain solid hardened layers in a short treatment time makes boron saturation from pastes a more attractive alternative among other chemical-heat treatment technologies.
Stylistic Interpretation of English Football Vocabulary Items and Set Expressions in Publicistic Discourse
Authors: Štulajterová Alena , Laluška Ivan 
Published: July 2020

The paper dwells upon the study of English football vocabulary items and set expressions from the stylistic point of view. We applied Galperin´s model of stylistic analysis in our research,therefore football expressions and phrases are evaluated in terms of their stylistic significance at the phonetic-phonological, lexical and syntactical levels. The linguistic corpus of research material of 670 excerpts comes from printed and online British media, namely the Guardian and its websites. In initial chapters, the paper outlines the past and present of football on the British Isles. As football vocabulary items and set expressions are used by sports journalists and reporters too, we present a concise diachronic and synchronic view of the British sports journalism as the sub-style of publicistic style. The core of the paper is focused on quantitative and qualitative stylistic analysis of the corpus. Furthermore,the corpus of the language material has been analysed according to the football activities related to the most popular sport worldwide. Our research revealed that the scope of the most frequent stylistic devices included in the English football vocabulary has been mainly focused on the lexical level (namely metonymy, metaphor, hyperbole and periphrasis). The results provide some interesting insights into the two-fold application of meaning (primary and transferred/contextual meaning) in the analysed expressions.
The Russian Arctic seas ice age composition and thickness variation in winter periods at the beginning of the 21st century
Authors: Egorov A. G. 
Published: July 2020

The purpose of the paper is to analyze the large-scale peculiarities of ice age composition and thickness in winter period (October–May) along the entire stripe of the Russian Arctic seas from the Novaya Zemlya Archipelago to Alaska, as well as to assess the multi-year changes taking place in early 21st century. The source of the information used for the present paper is the electronic ice charts at the end of every month, developed in the AARI from 1997 to 2018.On the average, during the period 1997–2018, from month to month, the consecutive and ordered changes of ice area of given age take place in accordance with the general ice thickness increase. In October–December the grey-white and first year thin ice (15–70 cm) prevails in the Arctic seas, in January–February — the first-year medium ice (70–120 cm), in March–May — the first-year thick ice (more than 120 cm).The period from 1997 to 2018 consists of two parts (1997–2003 and 2004–2018) principally differing from one another by the peculiarities of ice age composition. The basic content of the changes in the 21st century is the decrease of relatively thicker ice area and increase of that of relatively thinner ice.On the average, in the winter periods of 2004–2018, (1) the area of ice thinner than 70 cm (nilas, grey, grey-white and first year thin) became 12 % less than in 1997–2003, and (2) the area of ice thicker than 70 cm (first year medium, first year thick, second year and multi-year) became 18 % larger than in 1997–2003. The most significant changes regard to the second year and multi-year ice, their area in winter period decreased about 10 times. Decrease of the rate of first year ice growth is accompanied with delay of the dates when the first year ice reaches the values of 70 and 120 cm.Correspondingly, the weighted mean ice thickness also changes. On the average, in 2004–2018 ice thickness has got about 40 cm less than in 1997–2003; by the end of cold period (May), ice thickness decrease from 153 to 117 cm.The typical feature of the observed changes is an abrupt transformation from one climatic state of ice cover to another during only one hydrological year.