bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scoring systemic lupus erythematosus (SLE) disease activity with simple, rapid outcome measures
Authors: Thanou Aikaterini , James Judith A , Arriens Cristina , Aberle Teresa , Chakravarty Eliza , Rawdon Joseph , Stavrakis Stavros , Merrill Joan T , Askanase Anca 
Published: December 2019

ObjectiveExisting methods for grading lupus flares or improvement require definition-based thresholds as increments of change. Visual analogue scales (VAS) allow rapid, continuous scaling of disease severity. We analysed the performance of the SELENA SLEDAI Physician’s Global Assessment (SSPGA) and the Lupus Foundation of America-Rapid Evaluation of Activity in Lupus (LFA-REAL) as measures of improvement or worsening in SLE.MethodsWe evaluated the agreement between prospectively collected measures of lupus disease activity [SLE Disease Activity Index (SLEDAI), British Isles Lupus Assessment Group Index 2004 (BILAG 2004), Cutaneous Lupus Area and Severity Index (CLASI), SSPGA and LFA-REAL] and response [(SLE Responder Index (SRI)-4 and BILAG-Based Combined Lupus Assessment (BICLA)] in a clinical trial.ResultsFifty patients (47 females, mean age 45 (±11.6) years) were assessed at 528 consecutive visits (average 10.6 (±4.1) visits/patient). Changes in disease activity compared with baseline were examined in 478 visit pairs. SSPGA and LFA-REAL correlated with each other (r=0.936), and with SLEDAI and BILAG (SSPGA: r=0.742 (SLEDAI), r=0.776 (BILAG); LFA-REAL: r=0.778 (SLEDAI), r=0.813 (BILAG); all p<0.0001). Changes (∆) in SSPGA and LFA-REAL compared with screening correlated with each other (r=0.857) and with changes in SLEDAI and BILAG (∆SSPGA: r=0.678 (∆SLEDAI), r=0.624 (∆BILAG); ∆LFA-REAL: r=0.686 (∆SLEDAI) and 0.700 (∆BILAG); all p<0.0001). Changes in SSPGA and LFA-REAL strongly correlated with SRI-4 and BICLA by receiver operating characteristic analysis (p<0.0001 for all). Additionally, LFA-REAL correlated to individual BILAG organ scores (musculoskeletal: r=0.842, mucocutaneous: r=0.826 (p<0.0001 for both)).ConclusionSSPGA and LFA-REAL are reliable surrogates of common SLE trial end points and could be used as continuous or dichotomous response measures. Additionally, LFA-REAL can provide individualised scoring at the symptom or organ level.Trial registration numberNCT02270957.
Challenge of uncontrolled enteroatmospheric fistulas
Authors: Gross Daniel Jonathan , Smith Michael C , Zangbar-Sabegh Bardiya , Chao Kenneth , Chang Erin , Boudourakis Leon , Muthusamy Muthukumar , Roudnitsky Valery , Schwartz Tim 
Published: December 2019

IntroductionWith the popularization of damage control surgery and the use of the open abdomen, a new permutation of fistula arose; the enteroatmospheric fistula (EAF), an opening of exposed intestine spilling uncontrollably into the peritoneal cavity. EAF is the most devastating complication of the open abdomen. We describe and analyze a single institution’s experience in controlling high-output EAFs in patients with peritonitis.MethodsWe analyzed 189 consecutive procedures to achieve and maintain definitive control of 24 EAFs in 13 patients between 2006 and 2017. EAFs followed surgery for either trauma (seven patients) or non-traumatic abdominal conditions (six patients). All procedures were mapped onto an operative timeline and analyzed for: success in achieving definitive control, number of reoperations, and feasibility of bedside procedures in the surgical intensive care unit. The end point was controlled enteric drainage through a healed abdominal wound.ResultsThere was a mean delay of 8.5 days (range 2–46 days) from the index operation until the EAF was identified. Most EAFs required several attempts (mean: 2.7 per patient, range 1–7) until definitive control was achieved. Multiple reoperations were then required to maintain control (mean: 13). While the most effective techniques were endoscopic (1) and proximal diversion (1), these were applicable only in select circumstances. A ‘floating stoma’ where the fistula edges are sutured to an opening in a temporary closure device, while technically effective, required multiple reoperations. Tube drainage through a negative pressure dressing (tube vac) required the most maintenance usually through bedside procedures. Primary closure almost always failed. Twelve of the 13 patients survived.ConclusionAn EAF is a highly complex surgical challenge. Successful source control of the potentially lethal ongoing peritonitis requires tenacity and tactical flexibility. The appropriate control technique is often found by trial and error and must be creatively tailored to the individual circumstances of the patient.
Performance on the mouse vibration actuating search task is compromised by sleep deprivation
Authors: Bushana Priyanka N. , Koberstein John N. , Nguyen Theresa , Harvey Daniel O. , Davis Christopher J. 
Published: December 2019

As we go about our daily routines we are continuously bombarded with environmental feedback that requires appraisal and response. Sleep loss can compromise the efficiency by which these cognitive processes function. Operationally, poor performance caused by insufficient sleep translates to increased health and safety risks in settings where attention and timely and/or accurate decisions to respond are critical (e.g., at work, on the road, etc.). Current rodent tasks that assess altered cognition after sleep deprivation (SD) do not accurately model the continuous multisensory feedback that informs goal-oriented behavior in humans. Herein, we describe the vibration actuating search task (VAST), which consists of a vibrating open field with pseudo-randomly selected entrance and target destination points. To successfully complete a trial, mice use feedback from rotary motor-induced floor vibrations to navigate from the entrance point to the target destination. Sets of 20 trials were conducted on 3 consecutive days, and before testing on the third day control mice were undisturbed while other mice were sleep deprived for 10 h. On the first 2 days mice learned the task with high success rates. Alternatively, VAST performance was compromised following SD as measured by increased failures in task completion, time to target, time spent immobile, and decreased speed as compared with undisturbed mice. The VAST enables the analysis of continuous feedback via multiple sensory modalities in mice and is applicable to a variety of operational settings. NEW & NOTEWORTHY The vibration actuating search task (VAST) is a novel performance assay that uses continuous auditory and haptic feedback to motivate and direct search behaviors in mice. The VAST is rapidly acquired by mice and performance is disrupted by sleep deprivation. The VAST has practical application in occupational settings. The cognitive aspects of the sensorimotor integration in the VAST may prove useful for rodent models of neurodegenerative disease.
Notas sobre as transparências do filme em Theodor Adorno
Authors: Bergamaschi Alessandra 
Published: December 2019

O artigo propõe uma panorâmica sobre a dialética entre o mimético e construtivo na constituição da obra de arte, a partir de Teoria Estética, de Theodor Adorno. Essa elaboração servirá para fundamentar a leitura do artigo “Transparencies on Film”, no qual o autor discute as especificidades do filme e as possibilidades de resistência à indústria cultural que ele oferece enquanto obra de arte. Um ponto central nesse debate é a alegação de imediatismo e verossimilhança do fotográfico, que, a princípio, impediria as possibilidades construtivas da obra, aspecto fundamental para a arquitetura conceitual da estética de Adorno.
Cultura de museus no Brasil
Authors: Downey Clara 
Published: December 2019

Compreender a cultura de museus (isto é, o hábito de se visitar museus) em um país colonizado como o Brasil requer entender historicamente a gênese da criação dessas instituições, mesmo que de forma panorâmica. Como os museus vieram para o Brasil e aqui se desenvolveram? Para qual público foram criados e quais as relações com ele estabelecidas (e como elas mudaram ao longo dos anos)? Essas são algumas das questões que precisam ser analisadas, a fim de entender o que é necessário alterar, de modo que esses espaços tornem-se mais democráticos e acessíveis e que a apreciação do patrimônio artístico e o encontro com as obras contemporâneas possam se inserir no hábito e no anseio da população brasileira.
Manifestações da Liberdade
Authors: Souza Letícia Conceição de 
Published: December 2019

A Lei Áurea (1888) foi um evento marcante e problemático na história nacional. Frequentemente, os discursos propagados em torno dela excluem a participação da população negra no processo pela devolução da liberdade. O mesmo ocorre com as imagens decorrentes desse episódio, que refletem a ideologia e os valores da época sob o ponto de vista, principalmente, das classes sociais abastadas. À população negra foram atribuídos arquétipos específicos, amplamente disseminados. Este artigo discorrerá sobre a Coluna pela Liberdade dos Escravos, monumento realizado na cidade de Rio Grande, no Rio Grande do Sul, no contexto acima referido, a partir da perspectiva que busca considerar as operações de exclusão e representatividade envolvidas em sua criação.
KURUMSAL MARKALAR AÇISINDAN KRİZ İLETİŞİMİNİN ÖNEMİ: PINAR KRİZİ ÖRNEĞİ
Authors: AYDIN Ali Fikret 
Published: December 2019

Kriz dönemlerinde hedef kitle ile etkili bir iletişim
kurulamadığı ve kriz iyi yönetilmediği takdirde kurumsal markaya ilişkin
olumsuz bir algı oluşmakta ve kurumun itibarı sarsılabilmektedir. Dolayısıyla
krizlerin kurumsal markaya en az zarar verecek şekilde yönetilmesi büyük önem
taşımaktadır. Bunun için de kriz anlarında kurumsal markaların hedef kitlesi
ile hızlı bir şekilde iletişime geçerek onlara ikna edici ve bilgilendirici
mesajlar göndermesi gerekmektedir.

Çalışma
kapsamında, gıda sektöründe faaliyet gösteren “Pınar” markasının 2017 yılında
yaşadığı itibar krizinde, markanın kriz iletişimini nasıl gerçekleştirdiğini
tespit etmek amacıyla nitel araştırma yöntemlerinden bütüncül tek durum deseni
kullanılmıştır. Krize
Coombs’un itibarı onarma stratejileri açısından yaklaşılmıştır. Sonuç olarak
kurum tarafından destekleme ve onarma yönlü bir yaklaşımın sergilendiği
görülmüştür. Kurumun saldırgan ve suçlayıcı bir dilden uzak durarak yapıcı bir
söylemle iletişimi yönettiği tespit edilmiştir.
Modeling Task Scheduling Decisions of Emergency Department Physicians
Authors: Barg-Walkow Laura H. , Thomas Rickey P. , Wickens Christopher D. , Rogers Wendy A. 
Published: December 2019

Objective This study evaluated task-scheduling decisions in the context of emergency departments by comparing patterns of emergency physicians’ task-scheduling models across levels of experience. Background Task attributes (priority, difficulty, salience, and engagement) influence task-scheduling decisions. However, it is unclear how attributes interact to affect decisions, especially in complex contexts. An existing model of task scheduling, strategic task overload management-no priority (STOM-NP), found that an equal weighting of attributes can predict task-scheduling behavior. Alternatively, mathematical modeling estimated that priority alone could make similar predictions as STOM-NP in a parsimonious manner. Experience level may also influence scheduling decisions. Method An experimental design methodology shortened a judgment analysis approach to compare a priori task-scheduling decision strategies. Emergency physicians with two levels of experience rank-ordered 10 sets of 3 tasks varying on 4 task attributes in this complex environment. Results Bayesian statistics were used to identify best-fit decision strategies. STOM-NP and priority-only provided the best model fits. STOM-NP fit the lower-experienced physicians best, whereas priority-only—using only one cue—fit the higher-experienced physicians best. Conclusion Models of decision strategies for task-scheduling decisions were extended to complex environments. Experts’ level of experience influenced task-scheduling decisions, where the scheduling decisions of more-experienced experts was consistent with a more frugal decision process. Findings have implications for training and evaluation. Application We assessed models of cues that influence task-scheduling decisions, including a parsimonious model for task priority only. We provided a sample approach for shortening methods for understanding decisions.
Empowering Women Through Financial Inclusion: A Study of Urban Slum
Authors: Bhatia Shivangi , Singh Seema 
Published: December 2019

Executive Summary Financial Inclusion is considered to be a critical indicator for development and well-being of the society around the globe. Providing inclusive financial services, that is, financial services affordable for all, has become a basic priority in many countries including India. G-20 Nations have emphasized on financial inclusion as a facilitator for achieving gender equality and other sustainable development goals. Women empowerment is a radical approach concerned with transforming power relations in favour of female gender and considered essential for global progress. Thus, an inclusive financial model is being adopted in developing nations to achieve fundamental to formative objectives. The current article investigates the dimensions of women empowerment, that is, social, political, and economic. It also undertakes a test to see if the dimensions change with financial inclusion. The authors draw upon literature to develop a structured questionnaire on women empowerment and financial inclusion through schemes like Pradhan Mantri Jan Dhan Yojana (PMJDY), Pradhan Mantri Jivan Jyoti Bima Yojana (PMJJBY), Pradhan Mantri Suraksha Bima Yojana (PMSBY), and Atal Pension Yojana (APY) on women living in urban slums in the industrial town of Ludhiana, Punjab. The data were collected from 737 females living in urban slums with PMJDY bank accounts. The result indicated that PMJDY scheme has been quite successful especially in case of women in slums and has a positive influence on social, political, and economic dimensions of women empowerment. The study contributes to existing literature by advancing the debate on women in urban slums and identifies the substantial need for the development of formal financial system to enhance the scale of financial inclusion.
Financial Modelling for Business Sustainability: A Study of Business Correspondent Model of Financial Inclusion in India
Authors: Uzma Shigufta Hena , Pratihari Suvendu Kr. 
Published: December 2019

Executive Summary The study highlights the need for measures to accelerate the pace of the business correspondent (BC) model for financial inclusion in India. The financial analysis of the existing BCs with the existing products and services in practice shows a very diffusive break-even (more than 7 years). The occurrence of such a long-term break-even point can be a potential threat to the sustainability of new and struggling entrepreneurs like a Customer Service Point (CSP). A CSP agent runs a kiosk of a certain bank in a rural context, functioning like a BC between the bank and the beneficiaries. The primary investigation found that high cost and low volume of transaction at the CSP points are two major causes of the long break-even. In this context, the study revisited the constructs related to cost structure, market outreach, market potential and commission structure for channellizing respective banking and non-banking products. The major categories of products include (a) banking operation, (b) loan and over-draft, and (c) social security schemes. In search of a solution, the study adopts a non-random stratified sampling technique with a semi-structured interview process to collect the data from different stakeholders in the BC operation. To develop an economically viable BC model, the researchers use a standard financial modelling technique. In contrast to the existing kiosk model of CSP operation, the study found that while applying the new model a CSP agent takes three years to break-even under the same condition as that of the existing model. The study can also be applied in the domain of bottom of the pyramid (BOP) marketing by treating to create value among the low-income customers and business partners like CSPs. This research can further be extended to investigate the viability of the BC model from the banks’ return on investment perspective.
Treatment of auditory verbal hallucinations with atypical antipsychotics in healthy individuals: an artificially controlled post-treatment report
Authors: Shan Peiwei , Zhuo Chuanjun , Ma Xiaoyan , Sang Hong , Zhong Baoliang , Lin Xiaodong , Ji Feng , Chen Min , Tian Hongjun , Zhao Yanling , Pan Jianshe 
Published: December 2019

Objective This study was performed to investigate the effects and associated global functional connectivity density (gFCD) alterations associated with the use of atypical antipsychotics in healthy individuals with auditory verbal hallucinations (Hi-AVHs) using gFCD mapping techniques. Methods A magnetic resonance imaging database of 38 Hi-AVHs with chronic or severe AVH symptoms was generated. The Hi-AVHs were administered an atypical antipsychotic (risperidone) for 24 weeks and monitored for a treatment response. All patients underwent functional magnetic resonance imaging pre- and post-treatment. Results gFCD alterations were found in the auditory-memory-language and visual circuit regions pre- and post-treatment. However, gFCD alterations differed between patients with strong and weak treatment responses. Conclusion This is the first report to show that atypical antipsychotics can improve the symptoms of AVHs and that the treatment effects are associated with gFCD alterations in the auditory-memory-language circuit. These findings provide a foundation for future exploration of new treatment strategies for Hi-AVHs.
Effects of clean intermittent self-catheterization on late bladder dysfunction after radical hysterectomy in cervical cancer
Authors: Shen Xia , Wang Chun-lan , Wu Wan-ying , Liang Guan-mian , Xia Li-yao 
Published: December 2019

Objective To identify the benefits of clean intermittent self-catheterization in women who have late bladder dysfunction caused by radical hysterectomy in cervical cancer. Methods Thirty women who underwent radical hysterectomy with late bladder dysfunction were recruited. A nursing intervention program focusing on clean intermittent self-catheterization and a drinking plan was implemented. We recorded urinary times during the day and night, post-voiding residual urine volume, positive catheter specimen of urine rate, and quality of life instruments for patients with cervical cancer . Results All patients were able to satisfactorily manage clean intermittent self-catheterization following video-based operational training. Bladder function was significantly increased after 3-month intervention compared with before the intervention. Urinary times during the day and night, and post-voiding residual urine volume were greatly decreased post-intervention compared with pre-intervention. The rate of a positive catheter specimen of urine test significantly decreased over time. There was significant improvement in quality of life in five dimensions between weeks 1 and 12 following the intervention. Conclusions Patients are able to learn the technique of clean intermittent self-catheterization without any difficulty. This technique is effective together with a drinking plan to decrease late bladder dysfunction caused by radical hysterectomy in cervical cancer.
Meta-analysis of the association between MBD4 Glu346Lys polymorphism and cancer risk
Authors: Wang Jianguo , Shen Huaxiang , Liang Huijun 
Published: December 2019

Objective The purpose of this study was to systematically evaluate the association between methyl-CpG binding domain 4, DNA glycosylase ( MBD4) Glu346Lys polymorphism and cancer risk. Methods A comprehensive document retrieval from the Chinese National Knowledge Infrastructure (CNKI), EMBASE, and PubMed databases was performed through 1 September 2019. The strength of the correlation was assessed using the pooled odds ratio (ORs) and 95% confidence interval (CIs). Results Five relevant studies were retrieved following screening, including 1804 cases and 2193 controls. We found no association between MBD4 Glu346Lys polymorphism and cancer risk under all genetic models. Nevertheless, a subgroup analysis based on country showed a strong association in the Chinese population. Under the recessive model, Chinese individuals with the Lys/Lys genotype had a higher risk of cancer (OR = 1.37, 95% CI = 1.11–1.70). Conclusion Analysis of the MBD4 Glu346Lys polymorphism in different populations will help to elucidate the pathogenesis of cancer. The polymorphism can be utilized as a biomarker for cancer susceptibility among Chinese people.
Outcomes and Complications of Concurrent Pars Plana Vitrectomy and Scleral-Fixated Intraocular Lens Placement Using Gore-Tex Suture
Authors: Day H. Russell , Durrani Alia K. , Kim Stephen J. , Patel Shriji 
Published: December 2019

Purpose: The authors aim to describe the visual outcomes and postoperative complications of concurrent pars plana vitrectomy and scleral-fixated intraocular lens (IOL) placement using Gore-Tex suture. Methods: A retrospective review of medical records was performed on 27 eyes of 27 patients undergoing concurrent pars plana vitrectomy and scleral-fixated IOL with Gore-Tex suture. Outcome measures were change in preoperative and postoperative visual acuity, final manifest refraction, and incidence of intraoperative and postoperative complications. Results: The mean age was 69.2 ± 11.3 years; there were 16 male patients (59%). The duration of follow-up ranged from 33 to 576 days with a mean of 200 ± 143 days. All patients received Bausch + Lomb Akreos AO60 IOL. The overall mean best-corrected visual acuity in Snellen equivalent improved from 20/276 preoperatively to 20/44 postoperatively ( P < .001). The mean postoperative manifest spherical equivalent refraction was –0.35 ± 1.34 diopters (D). Seventy-five percent of eyes were ± 1.0 D of target refraction. Postoperative complications included corneal edema (26.0%), ocular hypertension (25.9%), hypotony (7.4%), cystoid macular edema (7.4%), vitreous hemorrhage (7.4%), and hyphema (3.7%). No cases of suture breakage, IOL dislocation, retinal detachment, or uveitis–glaucoma–hyphema syndrome were identified. Conclusions: The use of Gore-Tex suture for posterior chamber IOL fixation resulted in favorable outcomes. No suture-related complications occurred during the follow-up period. Final refraction in this setting is typically within ± 1.0 D of target.