bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of topical instillation of 0.1% diclofenac sodium, 0.5% ketorolac tromethamine, and 0.03% flurbiprofen sodium on corneal sensitivity in ophthalmologically normal cats
Authors: Roberts Jordan K. , Meekins Jessica M. , Roush James K. , Rankin Amy J. 
Published: December 2020

Abstract

OBJECTIVE
To investigate the effects of short-term and prolonged topical instillation of 0.1% diclofenac sodium, 0.5% ketorolac tromethamine, and 0.03% flurbiprofen sodium on corneal sensitivity (CS) in ophthalmologically normal cats.

ANIMALS
12 healthy adult domestic shorthair cats.

PROCEDURES
In the first of 2 study phases, each cat received 0.1% diclofenac sodium, 0.5% ketorolac tromethamine, 0.03% flurbiprofen sodium, and saline (0.9% NaCl; control) solutions (1 drop [0.05 mL]/eye, q 5 min for 5 treatments) in a randomized order with a 2-day washout period between treatments. For each cat, an esthesiometer was used to measure CS before treatment initiation (baseline) and at 15, 30, 45, and 60 minutes after the last dose. There was a 2-day washout period between phases. The second phase was similar to the first, except each treatment was administered at a dosage of 1 drop/eye, twice daily for 5 days and CS was measured before treatment initiation and at 15 minutes and 24 and 48 hours after the last dose. The Friedman test was used to evaluate change in CS over time.

RESULTS
None of the 4 treatments had a significant effect on CS over time in either study phase.

CONCLUSIONS AND CLINICAL RELEVANCE
Results indicated that neither short-term nor prolonged topical instillation of 3 NSAID ophthalmic solutions had any effect on the CS of healthy cats. Given potential differences in cyclooxygenase expression between healthy and diseased eyes, further investigation of the effects of topical NSAID instillation in the eyes of cats with ocular surface inflammation is warranted.
Gambaran imunohistokimia CD40 aorta jantung tikus wistar jantan (Rattus norvegicus) yang diinduksi minyak jelantah
Authors: Manihuruk Fani Nuryana , Rusip Gusbakti , Sitorus Esther R. D. , Ichwan M. 
Published: December 2020

Abstrak: Aterosklerosis adalah penyakit kronis yang dapat menyebabkan kematian diawali inflamasi pembuluh darah oleh hiperlipidemia. Pemakaian minyak jelantah menyebabkan peningkatan asam lemak trans, asam lemak bebas dan radikal bebas sehingga memicu terjadinya aterosklerosis. Salah satu biomarker aterosklerosis adalah CD40. Tujuan penelitian ini adalah untuk mengetahui gambaran imunohistokimia CD40 pada aorta jantung tikus Wistar jantan (Rattus norvegicus) yang diinduksi minyak jelantah. Penelitian ini adalah true experimental dengan rancangan randomize post-test only control group design. Jumlah sampel adalah 12 ekor tikus Wistar jantan sehat, umur 3-4 bulan dan berat 150-200 gram, dibagi menjadi 4 kelompok. K0(diet normal), K1(5 kali penggorengan), K2(10 kali penggorengan), K3(15 kali penggorengan) selama 60 hari dan menghitung score CD40. Hasil uji Kruskal-Wallis diperoleh adanya perbedaan yang bermakna antara keempat kelompok perlakuan (p0,05). Gambaran imunohistokimia CD40 pada K3(15 kali penggorengan) lebih tinggi dibandingkan K1 (5 kali penggorengan) dan K2 (10 kali penggorengan). Minyak jelantah dapat meningkatkan CD40 yang memicu aterosklerosis.Kata kunci: Aterosklerosis, minyak jelantah, CD40Abstract: Atherosclerosis is a chronic disease that cause death and begins inflammation of blood vessel by hiperlipidemia. It is associated with increased trans fatty acids, free fatty acids, and free radical compounds due consumption of deep frying oil that can trigger atherocslerosis. One of the biomarkers of atherosclerosis is CD40. The purpose of this study was to determine immunohistochemical images of CD40 in aorta of male Wistar rat (Rattus norvegicus) induced by deep frying oil. This research is true experimental with randomize post-test only control group design. The experimental animals were 12 healthy male Wistar rats age 3-4 month and weight between 150-200g. Male wistar rat were randomly divided into 4 group. Group K0 (control) was given standart diet, group K1 was given orally deep fried oil 5 times, group K2 was given orally deep fried oil 10 times, group K3 was given orally deep fried oil 15 times for 60 day. The Imunohistochemical examination assessed score of CD40. The Kruskal-Wallis test showed that imunohistochemical of CD40 were significantly different among the four groups (p0,05). Imunohistochemical of CD40 in group K3(deep fried 15 times) is higher than group K1(deep fried 5 times) and K2(deep fried 10 times). Deep frying oil inceased that mount of CD40 and induced risk of aterosclerosis.Keywords: Atherosclerosis, deep frying oil, CD40
Seorang penderita dengan enteropatik artritis
Authors: Firdausa Sarah , Yuliasih Yuliasih 
Published: December 2020

Abstrak. Enteropatik artritis adalah bentuk artritis yang terkait dengan penyakit peradangan usus kronis /irritable bowel disease (IBD) dengan manifestasi tersering berupa kolitis ulseratif, dan penyakit Crohn. Ini merupakan salah satu manifestasi klinis dari spondiloartritis seronegatif. Diare dan artritis merupakan dua hal yang sering muncul sebagai gejala klinis pada enteropatik artritis. Salah satu alarm symptom pasien enteropatik artritis adalah buang air besar (BAB) cair dan berdarah. Berikut dilaporkan seorang pasien dengan keluhan BAB berdarah yang disebabkan enteropatik artritis yang mendapat terapi non farmakologis dan farmakologis, pasien mengalami perbaikan secara klinis dan dapat menjalani terapi lanjutan secara optimal melalui poli rheumatologi. Kata kunci: Enteropatik artritis, diare berdarah, colitis Abstrak. Enteropathic arthritis is a form of arthritis which associated with chronic inflammatory bowel disease (IBD). The most common manifestations are ulcerative colitis and Crohn's disease. This is one of the clinical spectrum of seronegative spondylarthritis. Diarrhea and arthritis are two symptoms that often appear as clinical manifestation in enteropathic arthritis. One of the alarm symptoms of enteropathic arthritis patients is haematoschezia. In this article, we reported a patient with bloody diarrhea caused by enteropathic arthritis. He received non-pharmacological and pharmacological therapy, and experienced clinical improvement. He then can undergo optimal further therapy through poly rheumatology. Keywords: arthritis enteropathic, bloody diarrhea, colitis
Partial molar pregnancy with live fetus in first trimester: what should we do next
Authors: Edwin Eric , Budihastuti Uki Retno , Elnita Cut Sheira 
Published: December 2020

Abstract. The incidence of a normal live fetus with a partial mole is extremely rare, and it varies between 5 per 100000 and 1 per 10000 of the pregnancies. A partial molar pregnancy is a variation of a molar pregnancy in which an embryo either develops incompletely or with multiple structural anomalies.A 27-year-old Primigravide at 13 weeks of gestation got admitted with spotting per vaginam, excessive nausea and vomiting, and her ultrasound revealed a hydropic placenta with multiple cysts with a live fetus. Regarding these findings, the patient continued her pregnancy under close observation, and advanced sonographic evaluations were done to rule out other differentials. Ultrasonography found mosaicism in the partial mole (mostly diploid, a small part is triploid). In this condition, the prognosis condition for the fetus to be born safely is still probable. Ethics committee meetings are held with the consideration of the fetus's condition, whether monitoring is carried out regularly, and terminating the pregnancy in case of fetal emergency.The optimal management of hydatidiform mole with the coexistent live fetus is currently uncertain. Antenatal consultation should include a detailed discussion of maternal and fetal risks. It is also necessary to have close follow-up and evaluation of the patient's condition during the antenatal and postnatal period. Keywords: first trimester, live fetus , management, partial molar pregnancy
Periodik Paralisis Hipokalemia pada Anak Usia 15
Authors: Ismy Jufitriani 
Published: December 2020

Abstrak. Periodik paralisis hipokalemia menyebabkan kelemahan otot yang progresif terutama pada kelompok otot proksimal tungkai bawah, serangan akut dapat terjadi secara berulang. Serangan pertama biasanya terjadi antara usia 5 tahun dan 35 tahun, tetapi frekuensi serangan paling tinggi antara usia 15 dan 35 tahun. Ditemukan kasus Periodik paralisis hipokalemia yang berulang pada anak laki laki usia 15 tahun. Semua hasil analisis gejala klinis dan pemeriksaan penunjang sangat mendukung untuk diagnosis periodik paralisis hipokalemia.Kata kunci: periodik paralisis hipokalemia, kelemahan otot, usia 15 tahunAbstract. Periodic paralysis of hypokalemia causes progressive muscle weakness especially in the proximal lower leg muscle groups, acute attacks may occur repeatedly. The first attacks usually occur between the ages of 5 and 35, but the frequency of attacks is highest between the ages of 15 and 35. A case of recurrent hypokalemia periodic paralysis was found in a boy aged 15 years. All the results of clinical symptom analysis and investigations are very supportive for the diagnosis of periodic hypokalemia paralysis. Key words: periodic hypokalemia paralysis, muscle weakness, age 15 years
Tatalaksana demam berdarah dengue dalam kehamilan: A case series
Authors: Yeni Cut Meurah , Ayu Dara Meutia 
Published: December 2020

Abstrack. Demam berdarah dengue (DBD) adalah infeksi virus ditemukan pada negara-negara tropistermasuk Indonesia. Indonesia termasuk dalam katagori A dalam perkembangan penyakit virus tersebut yang mengindikasikan tingginya angka kematian. Angka insiden terus meningkat pada anak maupun dewasa dengan tingginya angka mortalitas. Tidak ada pencatatan lengkap untuk angka insidensi pada kehamilan, meskipun mortalitas cukup tinggi. Kami melaporkan empat kasus kehamilan dengan penyakit yang disebabkan oleh vektor Aedes aegypti. Pada keempat kasus tersebut kami telah diagnosis berdasarkan kriteria demam yang khas, trombositopenia, hemokonsentrasi dan pemeriksaan serologi. Terdapat penatalaksanaan yang berbeda dari berbagai kasus tersebut termasuk indikasi terminasi. Satu pasien kami rawat konservatif dan tiga pasien dilakukan terminasi berdasarkan indikasi obstetri. Pertimbangan cara terminasi sangat bergantung pula dengan indikasi obstetri. Seksio sesarea tidak secara mutlak dilakukan pada kehamilan dengan demam berdarah dengue. Kata kunci: Demam berdarah dengue, kehamilan, penatalaksanaan Abstract. Dengue hemorrhagic fever (DHF) is a viral infection found in tropical countries including Indonesia. Indonesia is included in category A in the development of viral diseases that's the high mortality rate. The numbers keep increasing on both adult children with high mortality rates. No complete logging for the incidence rate in pregnancy, although mortality is quite high. We reported four cases pregnancy with diseases caused by the Aedes aegypti vector. In four cases We had diagnosed based on criteria that met the specific criteria, thrombocytopenia, hemoconcentration and serology. There are different treatments for these cases includes the term indication. One patient was treated conservatively and three patients were admitted termination based on obstetric indications. The consideration on how to terminate is also very dependent with obstetric indications. Caesarean section is not absolutely necessary in pregnancy with dengue hemorrhagic fever. Keywords: Dengue hemorrhagic fever, pregnancy, management
História de vida de uma urna marajoara
Authors: Souza Lima Marcelle Rolim de , Barreto Cristiana , Lima Helena Pinto 
Published: December 2020

Este artigo se propõe a recuperar informações sobre a história de vida de uma importante urna funerária marajoara que integra o acervo arqueológico do Museu Paraense Emílio Goeldi, de modo a refletir sobre ações museais que tendem a desconectar objetos de seus contextos e individualizá-los. Ao analisarmos outros objetos encontrados no mesmo contexto arqueológico e evidenciar sua individualização e visibilização privilegiada em ações de extroversão, percebemos a construção de uma relação diferenciada entre objeto e público. A partir da análise de sua história de vida, avaliamos que uma nova proposta de alocação espacial da urna dentro da reserva técnica, junto às peças de seu contexto original de deposição, pode trazer novas possibilidades de releituras e ressignificações às coleções arqueológicas.
Model of Crisis Communication Management in the Perspective of Situational Crisis Communication Theory at the Transportation Ministry
Authors: Sulistyanto Ari , Usmar Usmar , Hermiyetti Hermiyetti 
Published: December 2020

Rapid disaster response is necessary since it involves various stakeholders in disaster. However, rapid response is difficult to implement due to structural constraints and organizational hierarchy. This research aims to reveal structural constraints to crisis communication management in the internal organization of the Transportation Ministry. Situational Crisis Communication Theory (SCCT) approaches offer a framework to understand management in general in responding to crisis situation. This research uses a qualitative method with case study approaches. The results of this research show that in the pre-crisis phase the organization serves as media for sections at the Transportation Ministry to interact in monitoring potential crisis. In the crisis and post-crisis response phases, the establishment of an Ad Hoc Crisis Communication Team (TKK) has changed the organization from being under stringent hierarchic structure to being more flexible and responsive in crisis response. This research gives contributions to more dynamic crisis communication management, recommends the formulation of Standard Operating Procedure (SOP) in crisis communication management, starting from pre-crisis, crisis to post-crisis response phases, and gives guidance to government and non-government organizations in crisis communication management.
Bilge Liderlik: Ahmet Ziylan’ın Hayatına İlişkin Nitel Bir Analiz
Authors: ARSLAN Mehmet Lütfi 
Published: December 2020

Amaç: Liderlik olgusunun anlaşılması için liderin anlatısı ve hayat hikâyesi önemli kaynaklardır. Bu araştırma, kunduracı çıraklığından sektör liderliğine uzanan bir liderlik öyküsünün merkezinde yer alan Ahmet Ziylan’ın anlatısını liderliğe biyografik yaklaşım bağlamında ele almaktadır.
Yöntem: Araştırma deseni; Ahmet Ziylan’ın kendi anlatısı ile biyografisidir. Veri kaynakları; araştırmacının yaptığı görüşme, Ziylan’ın anı, tecrübe ve değerlendirmelerini içeren 137 makalesi ile farklı zamanlarda verdiği beyanatlardır. İçerik betimsel analiz ve içerik analizine tabi tutulmuş, akabinde ortaya çıkan üç tema örneklendirilerek yorumlanmıştır.
Sonuçlar: Hikâyeler ve lider anlatısının analizi sonucu oluşan üç tema; ahlâkî ilkeler, kişisel gelişim yöntemi ve insanlarla ilişkiler şeklindedir. Bu üç temanın gösterdiği ortak anlam, klasik liderlik kalıplarının ötesine geçen hayata ilişkin derin ve bütüncül bir bilgelik anlayışıdır.
Özgün Değer: Hikâyeler ve lider anlatısının bir anlam üretimi olarak önemini ortaya koyan bu araştırma liderin başarısındaki temel saiklerin nitel lider yöntemleri ve özellikle içerik analizi ile daha iyi anlaşılabileceğini göstermektedir. Araştırma, liderlik çalışmalarının belli iş ve başarı kalıplarının ötesine geçmesi gerektiği ve sosyal bir gerçekliği deneyimlemek için daha bütüncül anlam setlerine gereksinim duyduğumuzu önermektedir.
The muscle fatigue of external anal sphincter in patients with anal incontinence
Authors: Фоменко О.Ю. , Шелыгин Ю.А. , Порядин Г.В. , Титов А.Ю. , Берсенева Е.А. , Мудров А.А. , Белоусова С.В. 
Published: December 2020

Цель - изучение зависимости утомляемости наружного сфинктера от наличия анальной инконтиненции и степени выраженности. Методы. Для выяснения зависимости утомляемости от наличия анальной инконтиненции обследовано 203 пациента с жалобами на недержание различных компонентов кишечного содержимого: 90 мужчин (44,3%), средний возраст 44,8 ± 14,7 года и 113 женщин (55,7%), средний возраст 46,4 ± 15,2 года. Для определения нормативных величин отобраны 53 пациента с полипами ободочной кишки, без клинико-инструментальных признаков анальной инконтиненции. В состав группы вошли 23 женщины (43,4%), средний возраст 51,4 ± 11,1 года и 30 мужчин (56,6%), средний возраст 65,1 ± 15,9 года. Использован разработанный в ФГБУ ГНЦК им. А.Н. Рыжих Минздрава России метод комплексной сфинктерометрии неперфузионным датчиком водного наполнения на приборе WPM Solar GI. Результаты и обсуждение. Получены нормативные показатели теста на выносливость наружного сфинктера. Не выявлено корреляции между степенью недостаточности анального сфинктера (по показателям давления в анальном канале) и одним из параметров утомляемости (временем падения давления на 50%), вероятнее всего из-за посттравматического характера недостаточности анального сфинктера. Предполагается продолжение работы по изучению утомляемости при различном генезе анальной инконтинеции.
The article presents materials on the muscle fatigue of the external sphincter in the norm and in patients with anal sphincter failure. The purpose. To determine the dependence of external sphincter fatigue on the presence of anal incontinence and its degree. Methods. 203 patients with complaints of incontinence of various components of intestinal contents were examined (90 male (44.3%), mean age is 44.8 ± 14.7 years, 113 female (55.7%) mean age is 46.4 ± 15.2 years) to determine the dependence of fatigue on the presence of anal incontinence. 53 patients with colon polyps without clinical and instrumental signs of anal incontinence were selected for the determination of normal values. 23 female (43.4%), mean age is 51.4 ± 11.1 years; 30 male (56.6%), mean age is 65.1 ± 15.9 years. For the study, we used the method of complex sphincterometry developed in State Scientific Centre of Coloproctology on the device WPM Solar GI (MMS, The Netherlands) with a nonperfusion water sensor. Results. We have received normal values for external sphincter endurance test. At the same time, there was no correlation between the degree of anal sphincter failure (in terms of pressure in the anal canal) and one of the fatigue parameters (the time of the pressure drop by 50%), most likely because of the post-traumatic nature of anal sphincter failure. We plan to continue studying fatigue with a different genesis of anal incontinence. Conclusion. We plan to continue studying fatigue with a different genesis of anal incontinence.
Interrelation between the number of ectopic foci and the chaoticity degree of ventricular fibrillation
Authors: Мезенцева Л.В. , Перцов С.С. 
Published: December 2020

Электрическая активность сердца при фибрилляции желудочков регистрируется на ЭКГ как хаотичное чередование разных по амплитуде и длительности возбуждений. Для количественного анализа этих показателей широко используются методы математического моделирования и теории хаоса. Цель исследования - использование методов математического моделирования для изучения взаимосвязи между степенью хаотичности процесса фибрилляции желудочков и количеством эктопических фокусов, функционирующих в миокарде желудочков. Электрическую активность сердца при фибрилляции желудочков моделировали суммой N-независимых импульсных потоков с различными амплитудно-частотными и фазовыми характеристиками. Степень хаотичности электрической активности сердца оценивали с помощью энтропии и фазовых портретов амплитуд фибриллярных осцилляций. Методом компьютерного моделирования рассчитывали теоретические зависимости степени хаотичности фибриллярных осцилляций от количества импульсных потоков. Результаты теоретических расчетов сопоставляли с результатами физиологических экспериментов, выполненных на крысах и собаках. Показано, что степень хаотичности фибриллярных осцилляций различна у крыс и собак и зависит от числа эктопических фокусов, функционирующих в миокарде желудочков. Для крыс были характерны двухочаговые типы моделей фибрилляции желудочков, для собак - многоочаговые (4-5 фокусов) типы моделей.
Cardiac electrical activity during ventricular fibrillation shows on electrocardiogram as chaotic alternation of excitations different in amplitude and duration. Methods of mathematical modeling and the chaos theory are widely used for quantitative analysis of these irregularities. The aim of the present work was using methods of mathematical modeling to study the interrelation between the chaoticity degree of ventricular fibrillation and the number of myocardial ectopic pacemakers. Cardiac electrical activity during ventricular fibrillation was modeled as a sum of N independent pulse streams with various amplitude-frequency and phase characteristics. The chaoticity degree of heart electrical activity was estimated using entropy and phase portraits of fibrillar oscillations. Theoretical dependences between the chaoticity degree of ventricular fibrillation and the number of pulse streams were calculated using computer modeling. Results of computer experiments were compared with those of real physiological experiments on rats and dogs. The chaoticity degree of fibrillar oscillations was shown to be different in rats and dogs and dependent on the number of ectopic pacemakers functioning in the myocardium. Two-focal types of ventricular fibrillation models were characteristic of rats and multifocal (4-5 foci) types we characteristic of dogs.
Chronic intermittent cold exposure does not influence blood pressure and resistance of the heart to ischemia and reperfusion
Authors: Цибульников С.Ю. , Маслов Л.Н. , Нарыжная Н.В. , Иванов В.В. 
Published: December 2020

Цель: исследовать периодическое воздействие холода на крыс самцов Вистар. Методика. Исследования проводились по двум протоколам (8 ч, +4°С, 4 нед.) и (1,5 ч, +4°С, 4 нед.). Ишемию (45 мин) моделировали путем перевязки левой нисходящей коронарной артерии, с последующей реперфузией (120 мин). Выявление зоны некроза и зоны риска проводили по методу J. Neckar и соавт. Определяли уровень кортизола и кортикостерона иммуноферментным методом. Результаты. Было установлено, что периодическое воздействие холода не является хроническим стрессом. Было показано, что периодическое воздействие холода на организм крыс не влияет на показатели гемодинамики и устойчивость сердца к патогенному действию ишемии и реперфузии. Заключение. Периодическое воздействие холода на организм крыс не влияет на показатели гемодинамики и устойчивость сердца к патогенному действию ишемии и реперфузии.Objective: To study the effect of periodic cold exposure on Wistar male rats. Methods: The study was conducted according to two protocols: 8 h at +4°С for 4 weeks and 1.5 h at +4°С for 4 weeks. Ischemia (45 min) was induced by ligation of the left descending coronary artery followed by reperfusion (180 min). Necrosis zone and area at risk were detected according to the method described by J. Neckar et al. Concentrations of cortisol and corticosterone were measured using the enzyme immunoassay. Results: The intermittent cold exposure was shown not to be chronic stress. The intermittent action of cold on the body of rats did not influence hemodynamic parameters or resistance of the heart to the detrimental effect of ischemia and reperfusion. Conclusion: The intermittent cold exposure of rats did not influence hemodynamic parameters or resistance of the heart to the detrimental effect of ischemia and reperfusion.