bluuebunny/crossref_metadata_2025_split huggingface dataset:
Helium abundances and its radial gradient from the spectra of H ii regions and ring nebulae of the Milky Way
Authors: Méndez-Delgado J E , Esteban C , García-Rojas J , Arellano-Córdova K Z , Valerdi M 
Published: June 2020

ABSTRACT
We determine the radial abundance gradient of helium in the disc of the Galaxy from published spectra of 19 H ii regions and ring nebulae surrounding massive O-type stars. We revise the Galactocentric distances of the objects considering Gaia DR2 parallaxes (Gaia Collaboration 2018) and determine the physical conditions and the ionic abundance of He+ in a homogeneous way, using between 3 and 10 He i recombination lines in each object. We estimate the total He abundance of the nebulae and its radial abundance gradient using four different ionization correction factor (ICF; He) schemes. The slope of the gradient is always negative and weakly dependent on the ICF(He) scheme, especially when only the objects with log(η) &lt; 0.9 are considered. The slope values go from −0.0078 to −0.0044 dex kpc−1, consistent with the predictions of chemical evolution models of the Milky Way and chemodynamical simulations of disc galaxies. Finally, we estimate the abundance deviations of He, O, and N in a sample of ring nebulae around Galactic Wolf–Rayet stars, finding a quite similar He overabundance of about +0.24 ± 0.11 dex in three stellar ejecta ring nebulae.
The edge of the Galaxy
Authors: Deason Alis J , Fattahi Azadeh , Frenk Carlos S , Grand Robert J J , Oman Kyle A , Garrison-Kimmel Shea , Simpson Christine M , Navarro Julio F 
Published: June 2020

ABSTRACT
We use cosmological simulations of isolated Milky Way (MW)-mass galaxies, as well as Local Group (LG) analogues, to define the ‘edge’ – a caustic manifested in a drop in density or radial velocity – of Galactic-sized haloes, both in dark matter and in stars. In the dark matter, we typically identify two caustics: the outermost caustic located at ∼1.4r200m, corresponding to the ‘splashback’ radius, and a second caustic located at ∼0.6r200m, which likely corresponds to the edge of the virialized material that has completed at least two pericentric passages. The splashback radius is ill defined in LG-type environments where the haloes of the two galaxies overlap. However, the second caustic is less affected by the presence of a companion, and is a more useful definition for the boundary of the MW halo. Curiously, the stellar distribution also has a clearly defined caustic, which, in most cases, coincides with the second caustic of the dark matter. This can be identified in both radial density and radial velocity profiles, and should be measurable in future observational programmes. Finally, we show that the second caustic can also be identified in the phase–space distribution of dwarf galaxies in the LG. Using the current dwarf galaxy population, we predict the edge of the MW halo to be 292 ± 61 kpc.
The Case for Feminist Legal History
Authors: Rackley Erika , Auchmuty Rosemary 
Published: June 2020

Abstract
While we may be witnessing a highpoint of interest in the lives of early women lawyers, and women’s legal history generally, feminist legal history remains largely undeveloped in the UK. Drawing on examples of women’s representation in and engagement with law and law reform in the UK and Ireland, this article delineates the method, scope and purpose of feminist legal history. It begins by exploring the place of women in traditional accounts of legal history, before going on to consider the methodological and substantive goals of feminist legal history. We argue that feminist legal history is a political project, requiring its authors to commit not only to uncovering untold stories, but also to challenging and revising dominant historical narratives. We conclude with a call for scholars to take up the insights and methods of feminist legal history as a means of acknowledging and celebrating the agency of those involved in past and ongoing struggles for justice and equality.
Case Series: Deep Brain Stimulation for Facial Pain
Authors: Kashanian Alon , DiCesare Jasmine A T , Rohatgi Pratik , Albano Luigi , Krahl Scott E , Bari Ausaf , De Salles Antonio , Pouratian Nader 
Published: June 2020

Abstract

BACKGROUND
Deep brain stimulation (DBS) has been used for chronic pain for decades, but its use is limited due to a lack of reliable data about its efficacy for specific indications.

OBJECTIVE
To report on 9 patients who underwent DBS for facial pain, with a focus on differences in outcomes between distinct etiologies.

METHODS
We retrospectively reviewed 9 patients with facial pain who were treated with DBS of the ventral posteromedial nucleus of the thalamus and periventricular gray. We report on characteristics including facial pain etiology, complications, changes in pain scores using the visual analog scale (VAS), and willingness to undergo DBS again.

RESULTS
Nine patients underwent DBS for either poststroke, post-traumatic, postherpetic, or atypical facial pain. Eight patients (89%) were permanently implanted. Seven patients had sufficient follow-up (mean 40.3 mo). Of these 7 patients, average VAS scores decreased from 9.4 to 6.1 after DBS. The average decrease in VAS was 55% for post-traumatic facial pain (2 patients), 45% for poststroke (2 patients), 15% for postherpetic neuralgia (2 patients), and 0% for atypical facial pain (1 patient). Three of the 8 implanted patients (38%) had complications which required removal of hardware. Only 2 of 7 (29%) patients met classical criteria for responders (50% decrease in pain scores). However, among 4 patients who were asked about willingness to undergo DBS again, all expressed that they would repeat the procedure.

CONCLUSION
There is a trend towards improvement in pain scores following DBS for facial pain, most prominently with post-traumatic pain.
THE VALIDATION OF COMPREHENSIVE SOFTWARE FOR THE ASSESSMENT OF RADIOLOGICAL IMPACTS ON HUMANS THROUGH BENCHMARK ANALYSIS WITH RADIOLOGICAL CODES
Authors: Shad Ali Haghighi , Allaf Mitra Athari , Masti Darioush , Sepanloo Kamran , Feghhi Seyed Amir Hossein 
Published: June 2020

Abstract
In this paper, a novel domestic code called KIANA was developed for the assessment of radiological impacts on the population in normal and accident conditions including design basis accident (DBA) and beyond DBA (BDBA) for the nuclear power plants. The validation process of the KIANA code was performed using the results of the DOZA_M radiological code, whose results are presented in the Final Safety Analysis Report (FSAR) of the Bushehr Nuclear Power Plant Unit One (BNPP-1). The calculations of KIANA are performed based on the Gaussian diffusion model. The developed KIANA code has the potential of calculating the concentration and radionuclide doses due to the pathways such as airborne, foodstuff, marine (both one and two boxes models), soils, animals, vegetation (with and without tritium) and other pathways without any restriction. In the current research, the individual dose from a cloud to the member of the public in the region of BNPP-1 in normal condition was calculated. Moreover, the total effective dose to the member of the public from the primary to the secondary leakage inside steam generators, large break loss-of-coolant accident (LBLOCA) and small break loss-of-coolant accident was calculated. Thyroid gland equivalent dose for the infant (1–8 years) in the case of LBLOCA at the BNPP in DBA conditions was also evaluated. Finally, the prevented dose at the initial stage for the whole body of adults after BDBA, prevented dose at the initial stage for the thyroid gland of children after BDBA and the effective dose during the first year after the accident (external body irradiation from presence in the area) in the case of BDBA are assessed. The KIANA simulation results showed a good agreement with the FSAR data of BNPP.
Efficacy of Incontinence-Associated Dermatitis Intervention for Patients in Intensive Care: An Open-Label Pilot Randomized Controlled Trial
Authors: Coyer Fiona , Campbell Jill , Doubrovsky Anna 
Published: June 2020

ABSTRACT

OBJECTIVE
To determine the feasibility of an adequately powered trial testing a long-acting cyanoacrylate skin protectant to prevent incontinence-associated dermatitis in critically ill patients.

METHODS
This open-label pilot randomized controlled feasibility study was conducted in the adult ICU of an Australian quaternary referral hospital. Patients were allocated to either an intervention group or a control group (usual care). The intervention was the application of a skin protectant (a durable, ultra-thin, transparent, waterproof, no-removal barrier film). Data collected by trained research nurses included demographic and clinical variables, skin assessment, and incontinence-associated dermatitis presence and severity. Data were analyzed using descriptive and inferential statistics.

RESULTS
Of the 799 patients screened, 85% were eliminated because of a short ICU stay or other exclusion criteria. The mean proportion of patients not meeting any of the exclusion criteria was 22% on each screening day. Protocol fidelity was followed for 90% of intervention participant study days. Retention of participants was 86% (31 participants out of 36), 15 in the intervention group and 16 in the control group. Enrolled patients had a mean age of 59 years, 50% were obese, 67% were male, and 36% were smokers. Two patients (11%) in the intervention group developed incontinence-associated dermatitis, compared with three (17%) in the control group.

CONCLUSIONS
This study reports no significant findings between the two groups. Difficulty in recruitment and feasibility issues might be overcome with changes to inclusion criteria and study design.
CE: The Effects of Smoking on Bone Health and Healing
Authors: Niu Stephanie , Lim Fidelindo 
Published: June 2020

ABSTRACT:
The number of orthopedic surgeries performed in the United States has increased substantially over the past several years. The most recent data available from the Agency for Healthcare Research and Quality indicate that five of the 10 operative procedures most commonly performed during inpatient stays involve the musculoskeletal system. Cigarette smoking is one of the most prevalent and preventable risk factors for musculoskeletal disorders and orthopedic surgery complications. This article discusses the effects of smoking on bone health, the importance of smoking cessation among patients scheduled for or recovering from orthopedic surgery, and the vital role nurses play in supporting patient efforts to lead a tobacco-free life.
Discharges “Against Medical Advice” in Patients With Opioid-related Hospitalizations
Authors: Santos Charles J. , Shofer Frances S. , Lowenstein Margaret , Perrone Jeanmarie 
Published: June 2020

Objectives:
We performed a descriptive analysis of patient and treatment characteristics in premature discharges “against medical advice” (AMA) in a cohort of patients with opioid-related hospitalizations.

Methods:
We abstracted data from 1152 opioid related hospitalizations of 928 adult patients in a large academic health system. Using electronic health record data, hospitalizations were categorized as AMA or conventional discharge (CD). To determine differences between AMA and CD regarding treatment characteristics, Fisher exact test, t tests, ANOVA, and logistic regression were performed.

Results:
74 / 1152 (6%) of opioid-related hospitalizations were discharged AMA. Hospitalizations that resulted in AMA discharge had shorter median length of stay (AMA vs CD 3.5 vs 5.5 days, P < 0.001) and received fewer of any type of opioid agonist treatment (AMA vs CD 73% vs 84%, P = 0.03). Although the number of hospitalizations in which methadone was administered did not differ between the AMA and CD groups, hospitalizations that resulted in AMA had more dose reductions and lesser quantities of methadone overall before discharge. Buprenorphine use was low overall in AMA and CD (0% and 2.1%, respectively)

Conclusion:
In this sample of opioid related hospitalizations, admissions that resulted in AMA discharge had fewer opioid agonist administrations and lower methadone dosing. These findings support efforts to initiate opioid agonist therapy during hospital admissions, and further studies should determine whether this practice mitigates AMA discharges.
Emotion Regulation, Impulsivity, and Personality Profile Among Egyptian Patients With Substance Use Disorders
Authors: Okasha Tarek , Abdelsamie Afaf , Azzam Hanan , Elserafi Doha , Shorub Eman M. , ElHawary Yomna , Morsy Mahmoud 
Published: June 2020

Objectives:
Emotion regulation deficits and impulsivity and personality profile as well play a role in the development and maintenance of substance use disorder (SUD). We aimed to examine the emotion regulation and both impulsivity and personality profile among patients with SUDs and its correlates.

Patients and Methods:
One hundred male patients with SUDs were selected from the inpatient and outpatient departments compared with 100 healthy controls matched for age, sex, and education. Structured Clinical Interview for the diagnostic and statistical manual of mental disorders (SCID-I); Temperement and Character Inventory, Barratt Impulsiveness Scale, Version 11 (BIS-11); and Trait Meta Mood Scale (TMMS) were used.

Results:
Emotional repair was significantly lower in cases compared with control group (P<0.05). Novelty seeking was significantly higher in patients with substance use. Meanwhile, cases had significantly lower scores in harm avoidance and persistence (P<0.01). In addition, cases showed significantly higher total, motor, attention, and nonplan scores of BIS compared with the control group (P<0.05). Furthermore, there was a negative correlation between attention to feeling, clarity of feeling, and repair of mood, and motor, attention, nonplan, and total scores of BIS. Meanwhile, there was a negative correlation between emotional repair and novelty seeking, harm avoidance, persistence, and self-transcendence.

Conclusion:
Deficits in emotional repair correlated with certain personality traits and impulsiveness may place individuals at more risk for SUD and are important variables to attend for proper management of SUD patients.
Better Hearing in Norway: A Comparison of Two HUNT Cohorts 20 Years Apart
Authors: Engdahl Bo , Strand Bjørn Heine , Aarhus Lisa 
Published: June 2020

Objective:
To obtain updated robust data on a age-specific prevalence of hearing loss in Norway and determine whether more recent birth cohorts have better hearing compared with earlier birth cohorts.

Design:
Cross-sectional analyzes of Norwegian representative demographic and audiometric data from the Nord-Trøndelag Health Study (HUNT)—HUNT2 Hearing (1996–1998) and HUNT4 Hearing (2017–2019), with the following distribution: HUNT2 Hearing (N=50,277, 53% women, aged 20 to 101 years, mean = 50.1, standard deviation = 16.9); HUNT4 Hearing (N=28,339, 56% women, aged 19 to 100 years, mean = 53.2, standard deviation = 16.9). Pure-tone hearing thresholds were estimated using linear and quantile regressions with age and cohort as explanatory variables. Prevalences were estimated using logistic regression models for different severities of hearing loss averaged over 0.5, 1, 2, and 4 kHz in the better ear (BE PTA4). We also estimated prevalences at the population-level of Norway in 1997 and 2018.

Results:
Disabling hearing loss (BE PTA4 ≥ 35 dB) was less prevalent in the more recent born cohort at all ages in both men and women (p < 0.0001), with the largest absolute decrease at age 75 in men and at age 85 in women. The age- and sex-adjusted prevalence of disabling hearing loss was 7.7% (95% confidence interval [CI] 7.5 to 7.9) and 5.3% (95% CI 5.0 to 5.5) in HUNT2 and HUNT4, respectively. Hearing thresholds were better in the more recent born cohorts at all frequencies for both men and women (p < 0.0001), with the largest improvement at high frequencies in more recent born 60- to 70-year old men (10 to 11 dB at 3 to 4 kHz), and at low frequencies among the oldest.

Conclusions:
The age- and sex-specific prevalence of hearing impairment has decreased in Norway from 1996–1998 to 2017–2019.
Uncertainties in Radiation Doses for a Case-control Study of Thyroid Cancer among Persons Exposed in Childhood to 131 I from Chernobyl Fallout
Authors: Drozdovitch Vladimir , Kesminiene Ausrele , Moissonnier Monika , Veyalkin Ilya , Ostroumova Evgenia 
Published: June 2020

Abstract
Uncertainties in thyroid doses due to 131I intake were evaluated for 2,239 subjects in a case-control study of thyroid cancer following exposure to Chernobyl fallout during childhood and adolescence carried out in contaminated regions of Belarus and Russia. Using new methodological developments that became available recently, a Monte Carlo simulation procedure was applied to calculate 1,000 alternative vectors of thyroid doses due to 131I intake for the study population of 2,239 subjects accounting for sources of shared and unshared errors. An overall arithmetic mean of the stochastic thyroid doses in the study was estimated to be 0.43 Gy and median dose of 0.16 Gy. The arithmetic mean and median of deterministic doses estimated previously for 1,615 of 2,239 study subjects were 0.48 Gy and 0.20 Gy, respectively. The geometric standard deviation of individual stochastic doses varied from 1.59 to 3.61 with an arithmetic mean of 1.94 and a geometric mean of 1.89 over all subjects of the study. These multiple sets of thyroid doses were used to update radiation-related thyroid cancer risks in the study population exposed to 131I after the Chernobyl accident.
Outcomes of Descemet Membrane Endothelial Keratoplasty in Aphakic and Aniridic Patients
Authors: Santaella Gisella , Sorkin Nir , Mimouni Michael , Trinh Tanya , Cohen Eyal , Chan Clara C. , Rootman David S. 
Published: June 2020

Purpose:
To evaluate the outcomes of Descemet membrane endothelial keratoplasty (DMEK) in aphakic and aniridic eyes.

Methods:
A retrospective chart review of either aphakic or aniridic patients who underwent DMEK at Toronto Western Hospital, Canada, between 2015 and 2019 was performed. Demographic characteristics, intraoperative and postoperative complications, and best corrected visual acuity (BCVA) were analyzed.

Results:
Nine eyes of 9 patients, aged 51.0 ± 8.6 years, were included (3 aniridic, 5 aphakic, and 1 combined). The average follow-up was 15.7 ± 12.7 months. The best corrected visual acuities before surgery and 3 and 6 months after surgery were 1.28 ± 0.47, 1.33 ± 0.98, and 1.03 ± 0.56 LogMAR, respectively. Six eyes (67%) had graft detachment, with 3 of them larger than 30% of the graft area. One eye (11%) developed hyphema. The overall failure rate was 88% (8 of 9 eyes), meaning only one was viable at the last follow-up. Primary graft failure was seen in 4 eyes (44%) after detachment (n = 3) and intraoperative hyphema (n = 1). Secondary failure occurred in 4 eyes (44%) at 7, 12, 15, and 36 months. The secondary failure at 36 months was after rejection. Failures were managed with penetrating keratoplasty (n = 2), repeat DMEK (n = 3), Descemet stripping automated endothelial keratoplasty (n = 1), and observation because of poor vision potential (n = 2). Cumulative graft survival probabilities at 12 and 24 months were 44% and 17%, respectively.

Conclusions:
Aniridic and aphakic patients experienced unacceptably high detachment and failure rates after DMEK. Before performing DMEK, the risks and benefits should be carefully weighed and perhaps other keratoplasty techniques should be used.
Peripheral tetrahydrobiopterin is involved in the pathogenesis of mechanical hypersensitivity in a rodent postsurgical pain model
Authors: Arai Hirokazu , Takahashi Rina , Sakamoto Yoshiaki , Kitano Tatsuya , Mashita Okishi , Hara Satoshi , Yoshikawa Satoru , Kawasaki Koh , Ichinose Hiroshi 
Published: June 2020

Abstract
Because treatment for postsurgical pain (PSP) remains a major unmet medical need, the emergence of safe and innovative nonopioid drugs has been strongly coveted. Tetrahydrobiopterin (BH4) is an interesting molecule for gaining a better understanding the pathological mechanism of neuropathic pain. However, whether BH4 and its pathway are involved in the pathogenesis of PSP remains unclear. In this study, we found that early in a rat paw incision model, the gene expression of GTP cyclohydrolase 1 (GTPCH) and sepiapterin reductase (SPR), BH4-producing enzymes in the de novo pathway, were significantly increased in incised compared with naive paw skin. Although a significant increase in GTPCH protein levels was observed in incised paw skin until only 1 day after incision, a significant increase in BH4 levels was observed until 7 days after incision. In vivo, Spr-knockout mice showed an antinociceptive phenotype in the hind paw incision compared with the wild-type and Spr heterozygote groups. Furthermore, QM385, the SPR inhibitor, showed a significant dose-dependent, antinociceptive effect, which was supported by a reduction in BH4 levels in incised skin tissues, with no apparent adverse effects. Immunohistochemical analysis demonstrated that macrophages expressing GTPCH protein were increased around the injury site in the rat paw incision model. These results indicate that BH4 is involved in the pathogenesis of PSP, and that inhibition of the BH4 pathway could provide a new strategy for the treatment of acute PSP.
A Fast-Track Care by a Nursing Case Management Concept Improved Status Epilepticus Outcomes
Authors: Pranboon Sineenard , Tiamkao Somsak , Chainirun Nanthaphan , Sawanyawisuth Kittisak 
Published: June 2020

ABSTRACT

BACKGROUND
Status epilepticus (SE) is an emergency neurological condition, which is life-threatening, results in high morbidity and mortality rates, and needs to be diagnosed and promptly cared for. This study aimed to develop and evaluate the SE fast-track care using a nursing case management concept on SE outcomes.

METHODS
Quasi-experimental study conducted in adult patients with SE admitted in 15 emergency and intensive critical/intermediate care wards. SE outcomes were evaluated and compared between preintervention and postintervention.

RESULTS
Time to treatment was reduced from 30 minutes to 3.5 minutes (P < .001). Similarly, the seizure control rate increased from 65.7% to 94.4% (P = .009). The mortality rate was reduced but did not reach statistical significance (8.6% vs 0%; P = .115). The intervention also reduced average waiting time for receiving antiepileptic drugs from the pharmacy department from 13.09 minutes to < 1 minute.

CONCLUSION
The development of the fast-track care system for SE patients by nursing case management is at the core of management for coordinating multidisciplinary teams. This can improve outcomes by reducing the time to diagnosis and treatment time, therefore reducing mortality rates in SE patients.
The Mediating Effect of Unhealthy Behaviors and Body Mass Index in the Relation Between High Physical Workload and Self-Rated Poor Health in Male Construction Workers
Authors: Proper Karin I. , Cillekens Bart , Twisk Jos W.R. , Coenen Pieter , Robroek Suzan J.W. , van Oostrom Sandra H. 
Published: June 2020

Objectives:
To examine the mediating role of unhealthy behaviors and body mass index (BMI) in the relation between high physical workload and self-rated health in male construction workers.

Methods:
Longitudinal data over 2010 to 2018 were used of 30,224 male construction workers in The Netherlands. Smoking, lack of physical activity, and alcohol consumption were self-reported. BMI was based on measured body weight and height. Multilevel modeling path analyses were used to determine the mediating role of unhealthy behaviors in the relation between physical workload and poor health.

Results:
A direct effect of high physical workload on poor health adjusted for unhealthy behaviors and BMI was found (odds ratio [OR] 1.49, 95% confidence interval [CI] 1.38 to 1.68). Indirect effects of the unhealthy behaviors and BMI in the relation between high physical workload and poor health were small (OR varying from 0.96 to 1.04).

Conclusion:
The pathway of high physical workload and poor health through unhealthy behaviors and BMI was not supported.