bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dengue Virus Capsid Protein Dynamics Reveals Spatially Heterogeneous Motion in Live-Infected-Cells
Authors: Gabriel Manuela , Navarro Guadalupe S. Costa , de Borba Luana , Rossi Andrés H. , Gamarnik Andrea V. , Estrada Laura C. 
Published: May 2020

AbstractDengue is the single most important human viral infection transmitted by insects. The function of the viral proteins andtheir interactions with the host cell is under exhaustive investigation with the aim of identifying antiviral strategies. Here,using recombinant full-length dengue virus genomes, carrying a fluorescent mCherry fused to capsid, we studied biophysicalproperties of the viral protein during one infectious cycle in living cells. Dengue virus capsid protein associates to differentcellular compartments but its function in these locations is largely unknown. We evaluated the diffusion of capsid inside the celland determined a higher effective diffusion coefficient in the cytoplasm than in the nucleus. Using advanced fluorescencecorrelation methods, including the recently developed two-dimensional pair correlation analysis, we constructed for the first timehigh resolution maps of capsid mobility in an infected cell. We observed that the motion of capsid in the nucleoplasm-nucleolusinterface was highly organized, indicating an obstacle in this interface. Although nucleoli are membraneless structures, theydisplayed liquid-liquid phase separation. Once inside nucleoli, the protein showed isotropic mobility, indicating free diffusion orimmobilized capsid inside these structures. This is the first study presenting spatial and temporal dynamics of the dengue viruscapsid protein during infection.
Potentials of organic manure and potassium forms on maize (Zea mays L.) growth and production
Authors: Kandil Essam E. , Abdelsalam Nader R. , Mansour Mansour A. , Ali Hayssam M. , Siddiqui Manzer H. 
Published: May 2020

AbstractWorldwide, maize (Zea maysL.) is considered an important food and fodder crop. Compost as a soil amendment and potassium (K) could enhance the maize yield. Therefore, two field experiments were carried out in the two seasons 2017 and 2018 to study the effects of compost at three levels and four forms of potassium fertilization on the yellow maize hybrid ‘PioneerSC30N11’ yield components. To conduct the field trials, a split plot system in three replications was established. Three compost levels (0, 5 and 10 ton/ha) were in the main plots, and four potassium forms (untreated, nano-potassium fertilizer, humic acid and potassium sulfate) were in the subplots. Plot size was 10.50 m2, with 5 ridges with 3 m length and 0.7 m width. The results indicated that the application of compost (as organic manure) and the potassium forms significantly affected the plant height, ear length, grains number/rows, grains number/ear, 100- grain weight, straw and biological yields, grain protein and K contents in both seasons. Increasing the compost from 5 to 10 ton/ha increased the yield, its components, protein and K contents. The foliar application of nano-potassium followed by humic acid increased all the studied characteristics. The interaction between compost manure (10 ton/ha) and nano-potassium (500 cm3/ha) or humic acid (10 ton/ha) recorded the highest mean values for all parameters during both harvest seasons.
Kefir peptides alleviate high-fat diet-induced atherosclerosis by attenuating macrophage accumulation and oxidative stress in ApoE knockout mice
Authors: Tung Min-Che , Lan Ying-Wei , Li Hsin-Han , Chen Hsiao-Ling , Chen Sheng-Yi , Chen Yu-Hsuan , Lin Chi-Chien , Tu Min-Yu , Chen Chuan-Mu 
Published: May 2020

AbstractIn the past decade, the high morbidity and mortality of atherosclerotic disease have been prevalent worldwide. High-fat food consumption has been suggested to be an overarching factor for atherosclerosis incidence. This study aims to investigate the effects of kefir peptides on high-fat diet (HFD)-induced atherosclerosis in apolipoprotein E knockout (ApoE−/−) mice. 7-week old male ApoE−/− and normal C57BL/6 mice were randomly divided into five groups (n = 8). Atherosclerotic lesion development in ApoE−/− mice was established after fed the HFD for 12 weeks compared to standard chow diet (SCD)-fed C57BL/6 and ApoE−/− control groups. Kefir peptides oral administration significantly improved atherosclerotic lesion development by protecting against endothelial dysfunction, decreasing oxidative stress, reducing aortic lipid deposition, attenuating macrophage accumulation, and suppressing the inflammatory immune response compared with the HFD/ApoE−/− mock group. Moreover, the high dose of kefir peptides substantially inhibited aortic fibrosis and restored the fibrosis in the aorta root close to that observed in the C57BL/6 normal control group. Our findings show, for the first time, anti-atherosclerotic progression via kefir peptides consumption in HFD-fed ApoE−/− mice. The profitable effects of kefir peptides provide new perspectives for its use as an anti-atherosclerotic agent in the preventive medicine.
A data-driven framework for selecting and validating digital health metrics: use-case in neurological sensorimotor impairments
Authors: Kanzler Christoph M. , Rinderknecht Mike D. , Schwarz Anne , Lamers Ilse , Gagnon Cynthia , Held Jeremia P. O. , Feys Peter , Luft Andreas R. , Gassert Roger , Lambercy Olivier 
Published: May 2020

AbstractDigital health metrics promise to advance the understanding of impaired body functions, for example in neurological disorders. However, their clinical integration is challenged by an insufficient validation of the many existing and often abstract metrics. Here, we propose a data-driven framework to select and validate a clinically relevant core set of digital health metrics extracted from a technology-aided assessment. As an exemplary use-case, the framework is applied to the Virtual Peg Insertion Test (VPIT), a technology-aided assessment of upper limb sensorimotor impairments. The framework builds on a use-case-specific pathophysiological motivation of metrics, models demographic confounds, and evaluates the most important clinimetric properties (discriminant validity, structural validity, reliability, measurement error, learning effects). Applied to 77 metrics of the VPIT collected from 120 neurologically intact and 89 affected individuals, the framework allowed selecting 10 clinically relevant core metrics. These assessed the severity of multiple sensorimotor impairments in a valid, reliable, and informative manner. These metrics provided added clinical value by detecting impairments in neurological subjects that did not show any deficits according to conventional scales, and by covering sensorimotor impairments of the arm and hand with a single assessment. The proposed framework provides a transparent, step-by-step selection procedure based on clinically relevant evidence. This creates an interesting alternative to established selection algorithms that optimize mathematical loss functions and are not always intuitive to retrace. This could help addressing the insufficient clinical integration of digital health metrics. For the VPIT, it allowed establishing validated core metrics, paving the way for their integration into neurorehabilitation trials.
Steric occlusion regulates proximal interactions of acyl carrier protein domain in fungal fatty acid synthase
Authors: Lou Jennifer W. , Mazhab-Jafari Mohammad T. 
Published: May 2020

AbstractThe acyl carrier protein (ACP) domain shuttles substrates and reaction intermediates in type I fungal fatty acid synthases via transient protein-protein interactions. Here, using electron cryo-microscopy (cryoEM), we report the structure of a fungal FAS stalled at the dehydration reaction, which precedes the final enoyl reduction in the fatty acid biosynthesis cycle. This conformation revealed multiple contact sites between ACP and the dehydratase (DH) and enoyl reductase (ER) domains that occluded the ACP binding to the adjacent ER domain. Our data suggests a minimal path from the DH to the ER reaction site that requires minute changes in the coordinates of the structured N- and C- termini of the ACP domain.
Megahertz single-particle imaging at the European XFEL
Authors: Sobolev Egor , Zolotarev Sergei , Giewekemeyer Klaus , Bielecki Johan , Okamoto Kenta , Reddy Hemanth K. N. , Andreasson Jakob , Ayyer Kartik , Barak Imrich , Bari Sadia , Barty Anton , Bean Richard , Bobkov Sergey , Chapman Henry N. , Chojnowski Grzegorz , Daurer Benedikt J. , Dörner Katerina , Ekeberg Tomas , Flückiger Leonie , Galzitskaya Oxana , Gelisio Luca , Hauf Steffen , Hogue Brenda G. , Horke Daniel A. , Hosseinizadeh Ahmad , Ilyin Vyacheslav , Jung Chulho , Kim Chan , Kim Yoonhee , Kirian Richard A. , Kirkwood Henry , Kulyk Olena , Küpper Jochen , Letrun Romain , Loh N. Duane , Lorenzen Kristina , Messerschmidt Marc , Mühlig Kerstin , Ourmazd Abbas , Raab Natascha , Rode Andrei V. , Rose Max , Round Adam , Sato Takushi , Schubert Robin , Schwander Peter , Sellberg Jonas A. , Sikorski Marcin , Silenzi Alessandro , Song Changyong , Spence John C. H. , Stern Stephan , Sztuk-Dambietz Jolanta , Teslyuk Anthon , Timneanu Nicusor , Trebbin Martin , Uetrecht Charlotte , Weinhausen Britta , Williams Garth J. , Xavier P. Lourdu , Xu Chen , Vartanyants Ivan A. , Lamzin Victor S. , Mancuso Adrian , Maia Filipe R. N. C. 
Published: May 2020

AbstractThe emergence of high repetition-rate X-ray free-electron lasers (XFELs) powered by superconducting accelerator technology enables the measurement of significantly more experimental data per day than was previously possible. The European XFEL is expected to provide 27,000 pulses per second, over two orders of magnitude more than any other XFEL. The increased pulse rate is a key enabling factor for single-particle X-ray diffractive imaging, which relies on averaging the weak diffraction signal from single biological particles. Taking full advantage of this new capability requires that all experimental steps, from sample preparation and delivery to the acquisition of diffraction patterns, are compatible with the increased pulse repetition rate. Here, we show that single-particle imaging can be performed using X-ray pulses at megahertz repetition rates. The results obtained pave the way towards exploiting high repetition-rate X-ray free-electron lasers for single-particle imaging at their full repetition rate.
Nature of the spin resonance mode in CeCoIn5
Authors: Song Yu , Wang Weiyi , S. Van Dyke John , Pouse Naveen , Ran Sheng , Yazici Duygu , Schneidewind A. , Čermák Petr , Qiu Y. , Maple M. B. , Morr Dirk K. , Dai Pengcheng 
Published: May 2020

AbstractSpin-fluctuation-mediated unconventional superconductivity can emerge at the border of magnetism, featuring a superconducting order parameter that changes sign in momentum space. Detection of such a sign-change is experimentally challenging, since most probes are not phase-sensitive. The observation of a spin resonance mode (SRM) from inelastic neutron scattering is often seen as strong phase-sensitive evidence for a sign-changing superconducting order parameter, by assuming the SRM is a spin-excitonic bound state. Here we show that for the heavy fermion superconductor CeCoIn5, its SRM defies expectations for a spin-excitonic bound state, and is not a manifestation of sign-changing superconductivity. Instead, the SRM in CeCoIn5 likely arises from a reduction of damping to a magnon-like mode in the superconducting state, due to its proximity to magnetic quantum criticality. Our findings emphasize the need for more stringent tests of whether SRMs are spin-excitonic, when using their presence to evidence sign-changing superconductivity.
Hand drauf!
Authors: Tetling Christiane 
Published: May 2020

SummaryTuina zählt als traditionelle chinesische Manualtechnik zu den fünf Säulen der TCM und reicht von muskulärer Massage über Faszienbehandlung bis hin zu Akupressur und chiropraktischer Manipulation. Entsprechend der TCM-Diagnose soll die Zirkulation von Qi und Blut reguliert werden, wobei Techniken wie Reiben, Schieben, Pressen, Kneten oder Kneifen zur Anwendung kommen. Die Behandlung eignet sich insbesondere bei Schmerzen, muskulären Verspannungen, Menstruations-, Verdauungs- und Schlafstörungen sowie zur Entspannung.
“In the evening, I don’t walk in the park”: The interplay between street lighting and greenery in perceived safety
Authors: Rahm Johan , Sternudd Catharina , Johansson Maria 
Published: May 2020

AbstractWalking as a means of transportation is a key feature in sustainable urban design, but few studies have examined the influence of micro-level environmental features, such as vegetation and street lighting, on perceived safety and people’s choice to walk. This study applied a non-explicit approach to examine the relationship between greenery, street lighting, perceived safety, and walking in an urban context. Participants from three neighbourhoods in Malmö, Sweden, took part in focus group discussions concerning neighbourhood qualities related to walking.A qualitative analysis revealed four inter-related themes relevant for perceived safety after dark: avoidance, entrapment, presence of others, and prospect (visual overview of the nearby surroundings). The quality of urban greenery and street lighting impacted people’s route choices after dark, and some participants felt compelled to make detours. Entrapment, partly due to unkempt greenery in combination with darkness, contributed to avoidance, whereas the presence of other people had the opposite effect. The results indicate that urban greenery and street lighting must be considered together, since their interaction influences perceived safety and impacts the walkability of the neighbourhood.
Stretching and folding sustain microscale chemical gradients in porous media
Authors: Heyman Joris , Lester Daniel R. , Turuban Régis , Méheust Yves , Le Borgne Tanguy 
Published: May 2020

Significance
Porous media flows are central to environmental, industrial, and biological systems, where they transport molecules, particles, and microorganisms and trigger important biogeochemical reactions. There is increasing evidence that many of these processes are highly sensitive to chemical gradients below the pore-scale. However, it is unknown how porous architectures control microscale concentration heterogeneities. Here, we provide high-resolution experimental images that fully resolve three-dimensional pore-scale mixing dynamics. We show that grain contacts control the folding of fluid elements in the pore space, which, in addition to fluid stretching at stagnation points, leads to the exponential enhancement of microscale concentration gradients. We use these insights to derive a kinematic model linking mixing rates to pore geometry, opening perspectives for reactive transport modeling.
Nonlinear effects in superconducting thin film microwave resonators
Authors: Thomas C N , Withington S , Sun Z , Skyrme T , Goldie D J 
Published: May 2020

Abstract
We discuss how reactive and dissipative nonlinearities affect the intrinsic response of superconducting thin-film resonators. We explain how most, if not all, of the complex phenomena commonly seen can be described by a model in which the underlying resonance is a single-pole Lorentzian, but whose centre frequency and quality factor change as external parameters, such as readout power and frequency, are varied. What is seen during a vector-network-analyser measurement is series of samples taken from an ideal Lorentzian that is shifting and spreading as the readout frequency is changed. According to this model, it is perfectly proper to refer to, and measure, the resonant frequency and quality factor of the underlying resonance, even though the swept-frequency curves appear highly distorted and hysteretic. In those cases where the resonance curve is highly distorted, the specific shape of the trajectory in the Argand plane gives valuable insights into the second-order physical processes present. We discuss the formulation and consequences of this approach in the case of nonlinear kinetic inductance, two-level-system loss, quasiparticle generation, and a generic model based on a power-law form. The generic model captures the key features of specific dissipative nonlinearities, but additionally leads to insights into how general dissipative processes create characteristic forms in the Argand plane. We provide detailed formulations in each case, and indicate how they lead to the wide variety of phenomena commonly seen in experimental data. We also explain how the properties of the underlying resonance can be extracted from this data. Overall, our paper provides a self-contained compendium of behaviour that will help practitioners interpret and determine important parameters from distorted swept-frequency measurements.
Optimization condition of fluoride adsorption using activated clay
Authors: Mustakim Z , Purwaningtyas F Y , Leksono E B , Sarto  , Prasetya A 
Published: May 2020

Abstract
Drinking water which contain high concentration of fluoride can be harmful to teeth and bones. Clay was cleaned from its impurities then treated for 30 minutes at 700 oC and dissolved in HCl solution for 60 minutes. This research focused on the search for process conditions for absorbing fluoride dissolved in water bodies using local material-based adsorption methods using activated clay. The batch sorption experiment was carried out in 50 ml stirred glass contained 12.17 mg/L fluoride solution at operation temperature 25 oC, 35 oC and 45 oC, pH of 4, with 0.75 gr, 1 gr, and 1.25 gr of adsorbent weight. The solution samples were analysed by using visible spectrophotometer at 570 nm of the wavelength. From this research, the equilibrium reached in 60 minutes with 1.25 gr of adsorbent weight at operation temperature 45 oC with maximum 78% fluoride adsorbed. The isotherm models of fluoride removal mechanism fitted well of the Langmuir and Freundlich isotherm models and followed the pseudo second-order kinetics model.
Steel column planning using the American Institute of Steel Construction (AISC) 2010 method
Authors: Wahyuni  , Zein K C S , Muchlis  
Published: May 2020

Abstract
The latest SNI rules for steel structure building has been published namely SNI 1729-2015 which refers to the AISC 2010. In AISC 2010, there is a new design method called Direct Analysis Method (DAM) as an alternative to the Effective Length Method (ELM). The aim of the study is to plan steel columns using the AISC 2010 method and calculate and also analyse the steel column capacity. In this study, ETABS computer analysis program that have been whole integrated includes the modelling, analysis and design were used, so as to produce safe and economical modelling, analysis and design. The results of trial and error showed that dimensions for the 1st and 2nd floor columns WF profile, 3rd and 4th floor columns used WF 250x250x9x14 profile, and the 5th floor column used WF 175x175x7.5x11 profile. The load that applied was only dead load and live load. ETABS analysis results obtained output in the column design in the form of axial force (P) 1688,971 kN, moment (Mux) 60,257 kN.m, moment (Muy) 23,009 kN.m. The calculation results of steel column design analysis using DAM method obtained the value of the ratio of the strengths of columns 1st and 2nd floors for 0.42, columns 3rd and 4th floors for 0.33 and the 5th floor for 0.15. The steel column material requirements for each 1st and 2nd floor are 352.66 kg, 2nd and 3rd floors are 271.35 kg, and the 5th floor is 150.75 kg. The design of steel columns by means of DAM results in a higher profile capacity, so that the profile designs used can be more economical.
The first proposed of fiber to the home (FTTH) protection unit for clients scattered placement
Authors: Ramza H , Aziz S A C , N Z , Mastang  , Ab-Rahman M S 
Published: May 2020

Abstract
This paper describes the design and analysis of protection schemes that it is not regular customers’ location in optical communication system network. Distance and number of customers with the design of optical point protection unit achievements are recognized as the user for a series of rings from CAPU-Ring 1 (Customer Access Protection Unit). CAPU-Ring 1 is made as a safety point of optics that will be placed on the prior user. This system is an optical spot that will be placed in a ring circuit for use in placement of clients scattered. Proposed construction of a series with a protection channel architecture is about designing CAPU-Ring 1 as optical nodes, condition and repair damage to the circuit, the power budget calculations, design in the simulation, and analysis of the node to node. Parameters outlined in this discussion are the relationship of each node optical output power, improving the system of the eye diagram to the distance and also increase the system working against the maximum optical node. Characterization of ring network protection architecture can be identified from the results of a simulation study.
Green productivity application for improving productivity and environmental performance through the selection of the best solution scenario in the agroindustry
Authors: Mubin A 
Published: May 2020

Abstract
Improving productivity and environmental performance is very important for agroindustry to improve performance and competitiveness.The application of the green productivity (GP) can help the company to be able to increase productivity and environmental performance in the same time. The purpose of this research is to improve the productivity and the environmental performance through improvement in the system of production by selecting alternative scenario as the best solution from some of alternative solution scenarios. The method of the research is conducted in several stages that are measuring process productivity and early environmental performance, arrangement of the improvement scenario system that can increase productivity and environmental performance simultaneously and provide suggestions for refurbishing and improving productivity and environmental performance. The result of the calculation from early productivity level is obtained the average of the past 7 period is 139.4%. While the value of early environmental performance is 0.69 which means that the quality of waste has met the standard of regulations, although they are still relatively small so they still needs to do restitution and improvement. The measurement value of green productivity index (GPI) is obtained that the existing condition, the scenario 1, the scenario 2 and scenario 3 are 1.39, 1.43, 1.45 and 1.41. Thus, then the selected best scenario is scenario 2, it is expected that the productivity and the environmental performance, as well as the competitiveness of companies can improve.
Classification of EEG signals uses the coefficient of wavelet transform and K-nearest neighbor
Authors: Hindarto H , Muntasa A , Efiyanti A 
Published: May 2020

Abstract
The research that was built was used to explain the application of Electroencephalography (EEG) signal waves. EEG data is used to move the cursor up and the cursor down. Characterization of each EEG signal uses the Wavelet method taken at each the subband of the wavelet process. Wavelet process by taking the average value and the standard deviation value of the wavelet coefficient. The average value and the standard deviation value is used as an EEG feature. K-Nearest Neighbor is used as an identification whether the cursor will move up or vice versa. This study uses of 100 EEG signal data consisting of 50 test data and 50 testing data. The accuracy of identification uses the 80% K-NN method.