bluuebunny/crossref_metadata_2025_split huggingface dataset:
A dynamic prediction model for time‐to‐peak
Authors: Langridge Mistaya , McBean Ed , Bonakdari Hossein , Gharabaghi Bahram 
Published: January 2021

AbstractA simplified empirical equation is developed for widespread prediction of dynamic catchment response time. This model allows for time‐to‐peak prediction to evolve from static, lumped models, thereby providing a single value for any storm within a given catchment, using a single set of input parameters, that can be applied to a dynamic model, thus accounting for the variability between storm sizes and catchment moisture conditions. These dynamic prediction methods are translated to North America for the first time. This allows the concepts and prediction methods for catchment response time prediction previously established for the United Kingdom (UK), to be translated to a simple empirical equation for use in North America, through the use of selected study areas in Canada and the United States. This reconfigured model is statistically successful in both the UK and North America and allows for a straightforward implementation of dynamic time‐to‐peak prediction. Further, the reconfigured model introduces the use of a runoff coefficient (Rc) to encompass historical catchment wetness, increasing the ease of incorporating antecedent moisture condition into predictions.
In vitro and in vivo evaluation of a novel bioresorbable magnesium scaffold with different surface modifications
Authors: Menze Roman , Wittchow Eric 
Published: January 2021

AbstractThe novel Resoloy® rare earth magnesium alloy was developed for bioresorbable vascular implant application, as an alternative to the WE43 used in Biotronik's Magmaris scaffold, which received CE approval in 2016. Initially, the Magmaris showed very promising preclinical and clinical results, but the formation of an unexpected conversion product and a too fast loss of integrity has proven to be a flaw. The safety and efficacy of Resoloy, which is intended to be bioresorbed without any remnants, has been investigated in an in vitro degradation study and a porcine coronary animal model. Four different groups of scaffolds composed of Resoloy (Res) as the backbone material and additionally equipped with a fluoride passivation layer (Res‐F), a polyester topcoat (Res‐P), or a duplex layer composed of a fluoride passivation layer and a polymeric topcoat (Res‐PF) were compared to a Magmaris scaffold in an in vitro degradation test. Preclinical safety and efficacy of Res‐F and Res‐PF were subsequently evaluated in a coronary porcine model for 12 and 28 days. Scanning electron microscope, quantitative coronary angiography, micro‐computed tomography, histopathology, and histomorphometry analyses were conducted to evaluate preclinical parameters and degradation behavior of the scaffolds. Res‐PF with a duplex layer shows the slowest degradation and the longest supporting force of all test groups. The in vitro data are confirmed by the results of the in vivo study, in which Res‐PF exhibited a longer supporting force than Res‐F, but also caused higher neointima formation. Both studied groups showed excellent biocompatibility. A starter colonization of the strut area with cells during bioresorption was observed. The in vitro degradation test shows that a combination of MgF2 passivation and a PLLA topcoat on a Resoloy magnesium backbone (Res‐PF) leads to a much slower degradation and a longer support time than a Magmaris control group. In a preclinical study, the safety and efficacy of this duplex layer could be demonstrated. The beginning colonization of the degraded strut area by macrophages can be seen as clear indications that the resorption of the intermediate degradation product takes a different course than that of the Magmaris scaffold.
Characterization of dental pulp stem cells isolated from a patient diagnosed with Crouzon syndrome
Authors: Torii Daisuke , Kobayashi Tomoko , Horie Tetsuro , Tsutsui Takeo W. 
Published: January 2021

AbstractStem cells isolated from patients with rare diseases are important to elucidate their pathogeny and mechanisms to enable regenerative therapy. However, the mechanisms underlying tissue regeneration using patient‐derived dental pulp stem cells (DPSCs) are unclear. In this study, we investigated the levels of mRNA and protein expression related to cellular differentiation of Crouzon syndrome patient‐derived DPSCs (CS‐DPSCs) with a Gly338Arg fibroblast growth factor receptor 2 mutation. Multipotency‐related gene expression levels were equivalent in both healthy donor DPSCs and CS‐DPSCs. CS‐DPSCs showed higher osteocalcin (OCN) expression than healthy donor DPSCs. CS‐DPSCs showed a lower increase in the rate of OCN expression among phorbol 12‐myristate 13‐acetate (PMA)‐treated cells than healthy donor DPSCs compared with untreated control cells. CS‐DPSCs showed a lower phosphorylation rate of p38 and p44/42 in PMA‐treated cells than healthy donor DPSCs compared with untreated control cells. These results demonstrate that CS‐DPSCs have higher OCN expression and lower PMA stimulation‐responsiveness than healthy donor DPSCs.
Phylogenetic analysis and evolutionary dynamics of H3N2 canine and feline influenza virus strains from 2006 to 2019
Authors: Shen Hai‐Xiao , Li Xin , Yang De‐Quan , Ju Hou‐Bin , Ge Fei‐Fei , Wang Jian , Zhao Hong‐jin 
Published: January 2021

AbstractH3N2 feline influenza virus (FIV) and canine influenza virus (CIV) are very common in cats and dogs. Due to the ability of the influenza virus to spread across hosts and frequent contact between pets and people, there exist huge public health problems. In this study, we collected H3N2 CIV and FIV genomes from 2006 to 2019 from NCBI and analyzed the evolutionary dynamics and molecular variation using a series of phylogenetic analysis methods. Results indicated that H3N2 FIVs were closely related to CIVs with high posterior probability and CIVs and FIVs have certain regional characteristics. However, compared with previous studies, the significance of geographical structure correlation decreased. Furthermore, we also found that the intrasubtypic reassortment between FIVs and CIVs were common during epidemics. The integrated analysis was also performed for different selection pressure acting on HA (566 codons), NA (469 codons), M1 (252 codons), and M2 (97 codons) proteins. One HA, two NA, three M1, and two M2 sites were found under positive selection. We subsequently performed the evolutionary dynamics of H3N2 CIV. The results indicated that the time of the most recent common ancestor of CIV H3N2 may have occurred earlier than indicated in a previous study. The Bayesian skyline plot analysis in this study showed the period of divergence of major H3N2 CIVs segments occurred between 2008 and 2010. Notably, according to our research, the PB1 has experienced two divergence periods (2006–2008 and 2009–2011).
SARS‐CoV‐2 nucleocapsid protein intranasal inoculation induces local and systemic T cell responses in mice
Authors: He Jia , Huang Jing‐Ru , Zhang Yao‐Lin , Zhang Jiyan 
Published: January 2021

AbstractSARS‐CoV‐2 nucleocapsid (N) protein has been proposed as a good vaccine target. N‐specific T cells were observed in SARS‐CoV‐2 N immunized mice and COVID‐19 convalescents. It is of importance to identify the T cell responses triggered by SARS‐CoV‐2 N protein. Intradermal immunization with SARS‐CoV N protein was demonstrated to elicit non‐protective T cell responses which may be avoided by intranasal vaccination. Therefore, we conducted intranasal vaccination of BALB/c mice with recombinant adenovirus type‐5 expressing SARS‐CoV‐2 N protein. Such procedure induced CD8 T cell responses in the lung. Meanwhile CD4 T cell responses were observed in the spleen, which was associated with robust antibody production. Our study further supports the notion that SARS‐CoV‐2 N protein can work as a target for vaccine development.
Molecular epidemiology and genetic diversity of norovirus infection in children with acute gastroenteritis in Bangladesh, 2014–2019
Authors: Dey Shuvra Kanti , Sharif Nadim , Billah Baki , Siddique Tanjir Tarek Ibn , Islam Tarequl , Parvez Anowar Khasru , Talukder Ali Azam , Phan Tung , Ushijima Hiroshi 
Published: January 2021

AbstractAcute gastroenteritis (AGE) is one of the most common diseases in children, and it continues to be a significant cause of morbidity and mortality worldwide. Norovirus is one of the major enteropathogens associated with both sporadic diarrhea and outbreaks of gastroenteritis. This study aims to investigate genotype diversity and molecular epidemiology of norovirus in Bangladesh. A total of 466 fecal specimens were collected from January 2014 to January 2019 from children below 5 years old with AGE in Bangladesh. All samples were analyzed by reverse transcriptase polymerase chain reaction to detect norovirus, and sequence analysis was conducted if found positive. Norovirus was detected in 5.1% (24 of 466) fecal specimens. Norovirus genotype GII.7 was predominant (62.5%, 15 of 24), followed by GII.3 (37.5%, 9 of 24). Coinfection between rotavirus and norovirus was found in 7 of 24 positive cases. Diarrhea (93.7%) and dehydration (89%) were the most common symptoms in children with AGE. About 80% of the positive cases were detected in children aged under 24 months. One seasonal peak (87.5% infection) was detected in the winter. This study suggests that norovirus continues to be one of the major etiologies of children AGE in Bangladesh. This study will provide a guideline to assess the burden of norovirus infection in Bangladesh, which will assist to combat against AGE.
Unlocking and closing the gender gap in creative performance: A multilevel model
Authors: Hora Snehal , Lemoine G. James , Xu Ning , Shalley Christina E. 
Published: January 2021

SummaryBuilding upon and extending the interactionist perspective of creativity, social role theory, and role congruity theory, we develop an integrated multilevel model to examine gender differences in creative self‐efficacy and determine how the contextual factor of team psychological safety shapes employees' creative self‐efficacy and, through this motivational mechanism, influences their creative performance. Using data from a sample of 335 employees from a large food manufacturer collected over three time periods, we theorize and demonstrate the pivotal role of creative self‐efficacy in explaining gender differences in creative performance. Our findings indicate that women may have lower creative self‐efficacy than men in organizational contexts. However, team psychological safety restores parity between men and women through a cross‐level moderated mediation, such that psychological safety has a stronger effect on women's creative self‐efficacy than that of men, resulting in increased creative performance for women. These findings offer interesting implications for research on gender differences in creative performance and for human resources by pinpointing methods of bridging the existent differences in the creative self‐efficacy of men and women in organizations.
Entering an upward spiral: Investigating how and when supervisors' talking about abuse leads to subsequent abusive supervision
Authors: Chen Chen , Qin Xin , Johnson Russell E. , Huang Mingpeng , Yang Mengyun , Liu Shengming 
Published: January 2021

SummaryResearch on abusive supervision that adopts an actor‐centric perspective has found that abusive acts have immediate cognitive and affective consequences for supervisors. Less immediate consequences are also possible when perpetrators engage in later sensemaking by talking with others about their actions that violated interpersonal norms. In this research, we explore whether, how, and when abusive supervision talk may affect supervisors' subsequent abusive supervision toward subordinates. Drawing upon cognitive‐motivational‐relational theory, we propose that abusive supervision talk enhances supervisors' hostility toward the abused subordinate, which in turn increases their subsequent abusive supervisory behavior toward the subordinate. We also propose that person‐centered responses by listeners (i.e., supervisors' coworkers) strengthen the positive indirect effect of abusive supervision talk on subsequent abusive supervisory behavior via hostility. Results from an experiment and a multi‐source, multi‐wave field study lend support to these predictions. We discuss the theoretical and practical implications of these findings and directions for future research.
Comparisons of the different definitions of the western Pacific pattern and associated winter climate anomalies in Eurasia and North America
Authors: Aru Hasi , Chen Shangfeng , Chen Wen 
Published: January 2021

AbstractThe western Pacific pattern (WP), characterized by a meridional dipole structure in geopotential height anomalies centred at approximately 50°N over the North Pacific, is one of the most prominent teleconnection patterns over the Northern Hemisphere (NH) in boreal winter. Several methods to identify the WP exist in the literature. Based on eight WP indices defined by different methods, this study analyses their dominant frequencies, spatial structures, climatic impacts, and relations to the Arctic Oscillation (AO) and El Niño‐Southern Oscillation (ENSO). The correlation coefficients of the eight WP indices show a considerable spread, but most of them are statistically significant. Most of the WPIs capture a pronounced power peak at approximately 5 years. The meridional dipole structure of the WP can be captured by all the WPIs, but it shows a large spread in the location of the centre. Several WPIs are significantly correlated with the winter AO, with marked signals of atmospheric anomalies over the Arctic region. The connections of the WP with the simultaneous winter ENSO depend largely on their definitions. The impacts of the WP on the surface air temperature over many parts of Eurasia and North America are also sensitive to its definition. Differences in surface air temperature anomalies are related to differences in the spatial structure of the WP as captured by the range of WPIs.
Knowledge, attitudes, and practices of mothers on the use of oral rehydration salts in children with diarrhoea: a cross‐sectional survey in Malaysia
Authors: Dujaili Juman Abdulelah , Blebil Ali Qais , Jayasinghe Dilhara , Sivanandan Nathiya 
Published: January 2021

AbstractBackgroundThe present study aimed to assess maternal knowledge, attitudes, and practices regarding the use of oral rehydration salts (ORS) in the treatment of childhood diarrhoea in Malaysia.MethodsA cross‐sectional study was conducted between 20 November and 20 December 2018. Mothers in different public places across Kuala Lumpur and Selangor were approached to complete a questionnaire. A non‐probability sampling method was used to collect data.ResultsA total of 400 mothers participated in the study. All mothers had received a formal education, with 80.2% having a tertiary education. 79.0% of participants managed to correctly define childhood diarrhoea, whereas 24.5% and 61.0% correctly identified all diarrhoea symptoms and the preventive approaches, respectively. However, only 49.0% knew that only treated or boiled water can be used to prepare ORS, while 78.8% were aware of the appropriate indication of ORS. The majority of respondents practice good hygiene when managing a child with diarrhoea.ConclusionAlthough mothers are equipped with reasonable knowledge regarding diarrhoea and ORS, certain issues identified in the study are disconcerting, namely the use of untreated water for ORS solution preparation, the inappropriate storage of ORS solution, and a lack of understanding regarding the urgency of ORS use. Hence, education interventions could prove useful in overcoming these false perceptions.
Pipette tip micro‐solid phase extraction (octyl‐functionalized hybrid silica monolith) and ultra‐high‐performance liquid chromatography‐tandem mass spectrometry to determine cannabidiol and tetrahydrocannabinol in plasma samples
Authors: Cruz Jonas Carneiro , Miranda Luís Felippe Cabral , Queiroz Maria Eugênia Costa 
Published: January 2021

AbstractThis manuscript describes the development of an innovative method to determine cannabinoids (cannabidiol and tetrahydrocannabinol) in human plasma samples by pipette tip micro‐solid phase extraction and liquid chromatography‐mass spectrometry/mass spectromtery. An octyl‐functionalized hybrid silica monolith, which had been synthesized and characterized, was used as a selective stationary phase. The octyl‐functionalized hybrid silica monoliths presented high permeability and adequate mechanical strength. The micro‐solid phase extraction variables (sample pH, draw‐eject cycles, solvent for phase clean‐up, and desorption conditions) were investigated to improve not only the selectivity but also the sorption capacity. The method was linear at concentrations ranging from the lower limit of quantification (10.00 ng/mL) to the upper limit of quantification (150.0 ng/mL). The lack of fit and homoscedasticity tests, as well as the determination coefficients (r2 greater than 0.995), certified that linearity was adequate. The precision assays presented coefficient of variation values lower than 15%, and the accuracy tests provided relative error values ranging from 3.2 to 14%. Neither significant carry‐over nor matrix effects were detected. Therefore, the pipette tip micro‐solid phase extraction/liquid chromatography‐mass spectrometry/mass spectrometry method has demonstrated to be adequate to determine cannabidiol and tetrahydrocannabinol simultaneously in plasma samples for therapeutic drug monitoring of patients undergoing treatment with cannabinoids.
Impact of long‐term sub‐soiling tillage on soil porosity and soil physical properties in the soil profile
Authors: Yang Yonghui , Wu Jicheng , Zhao Shiwei , Mao Yongping , Zhang Jiemei , Pan Xiaoying , He Fang , van der Ploeg Martine 
Published: January 2021

AbstractLong‐term conventional tillage leads to soil compaction and formation of a plough layer, which affects soil physical properties, transport of water, and growth of crop roots toward deeper soil, resulting in soil degradation and a decline in crop productivity. Long‐term sub‐soiling tillage has proven to be an effective measure for remediating the plough layer and improving the structure and physical properties of the soil. In this study, we experimentally investigated the effects of long‐term sub‐soiling tillage in an arid region of Henan Province, China, along a deep soil (0–100 cm) profile over 8 years of sub‐soiling tillage at a depth of 30 cm and compared the results against conventional tillage at a depth of 15 cm. We measured soil pore distributions of macropores (> 1 mm in diameter), mesopores (0.16–1.0 mm), and total pores (> 0.16 mm) measured by X‐ray computed tomography (CT), soil total porosity (ϕ) and > 0.16 mm equivalent porosity measured by conventional methods, soil bulk density (ρs), soil organic carbon content (SOC), the proportion of macroaggregates (> 0.25 mm) (PMA), soil field moisture capacity (fc), available moisture content, and saturated hydraulic conductivity (Ksat). The results indicate that long‐term sub‐soiling tillage increased soil pore numbers at 0–35 cm depth (macropores, mesopores, and total pores), improved pore shape, and significantly increased porosity at 0–20 cm depth (macropores, mesopores, and total pores; p < 0.05) compared to conventional tillage. In addition, ϕ and > 0.16 mm equivalent porosity were increased by 10.4 and 87.1% at depths of 0–60 cm under sub‐soiling tillage, respectively. SOC (0–55 cm depth), fc (0–45 cm depth), available moisture content (0–40 cm depth), Ksat (0–40 cm depth), and PMA (0–50 cm depth) were increased by 16.7, 14.3, 23.8, 471.5, and 98.3%, respectively, and ρs (0–60 cm depth) was reduced by 8.6%. Observed correlations between SOC, soil pore parameters, and soil physical properties suggest that soil pore parameters and soil physical properties can be improved by increasing SOC. These correlations are stronger under sub‐soiling than that under conventional tillage. Therefore, sub‐soiling is an effective technique for improving soil pore characteristics and physical properties while preventing soil degradation.
Enhancing distributed feedback‐standard single mode fiber‐radio over fiber links performance by neural network digital predistortion
Authors: Hadi Muhammad Usman , Murtaza Ghulam 
Published: January 2021

AbstractThis letter presents a novel neural network (NN) based digital predistortion (DPD) technique to obliterate the signal impairments and nonlinearities in radio over fiber (RoF) systems. DPD is generally performed with volterra based procedures that utilizes indirect learning architecture (ILA) that can become complex and expensive computationally. The proposed method using NNs evades issues associated with ILA and utilizes a NN to first model the RoF link and then training a NN based predistorter by backpropagating through the RoF NN model. Furthermore, the experimental evaluation is carried out for long term evolution 20‐MHz 256‐QAM modulation signal using 1310 nm distributed feedback laser, and standard single‐mode fiber to establish a comparison between NN based RoF link and volterra based generalized memory polynomial using ILA. The efficacy of the DPD is examined by reporting adjacent channel power ratio, mean square error, and error vector magnitude. The experimental findings imply that NN‐DPD convincingly learns the RoF nonlinearities which may not suit a volterra based model, and hence may offer a favorable trade‐off in terms of computational overhead and DPD performance.
A static and dynamic NMR study of 10‐hydrazino‐BODIPY
Authors: Reviriego Felipe , Peña‐Cabrera Eduardo , Kokate Siddhant V. , Alkorta Ibon , Elguero José 
Published: January 2021

Abstract10‐Hydrazino‐BODIPY, BoNHNH2, presents slow rotation about the C10–NH bond that results in anisochronous 1H and 13C NMR signals. The assignment of the different signals has been made using traditional two‐dimensional methods as well as spin–spin coupling constants and confirmed by DFT calculations (B3LYP) using the 6‐311++G(d,p) basis set. The rotational barrier has been determined in three pairs of proton signals and compared with the calculated barrier.
Alterations of macrophage and neutrophil content in skeletal muscle of aged versus young mice
Authors: Kawanishi Noriaki , Machida Shuichi 
Published: January 2021

AbstractBackgroundSkeletal muscle inflammation and oxidative stress are associated with aging‐related loss of muscle mass and may be attributable to alterations in the number and types of leukocytes in skeletal muscle. Here, we tested the hypothesis that aging changes the number and composition of leukocyte subsets in skeletal muscle tissue.MethodsSkeletal muscle was sampled from 4‐mo‐old (young) and 27‐mo‐old (old) C57BL/6J mice. Mononuclear cells of the gastrocnemius muscle were isolated, and flow cytometry was used to characterize the number and types of immune cells.ResultsThe number of neutrophils and Ly‐6C+ inflammatory macrophages in the skeletal muscle was significantly higher in old mice than in young mice. Inflammation and oxidative stress (measured using the markers phosphorylated JNK and nitrotyrosine) were also higher in the skeletal muscle of old mice than in that of young mice.ConclusionsIncreasing age promotes skeletal muscle inflammation and oxidative stress, as well as infiltration of inflammatory macrophages and neutrophils.