bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conclusion: Co-creating Inclusive Digital Futures
Authors: Jarke Juliane 
Published: September 2020

AbstractThe first and positive conclusion—relating to the governing of co-creation and the sharing of control—is that co-creation is indeed an appropriate method to develop digital public information services that meet the needs of older users and achieve an output that is better than existing, comparable services. The second conclusion—relating to the sharing of expertise and knowledge—is that the co-creation of digital services works well with older adults, including those with little or no digital literacy skills. However, the performance and achievements of co-creation processes seem highly contingent and dependent on several factors. The third conclusion—relating to enabling change—is that not every digital public service is equally suited for co-creation. A lasting social as well as individual change can only be implemented if the resulting service does indeed respond to the needs of local stakeholders. Co-creation may become a way to improve the lack of user-centricity and user experience of digital public information services. However, there is no guarantee for its success. It is a complex multi-task and multi-stakeholder process, more demanding than traditional citizen participation. Due to the openness and complexity inherent to any co-creation process, providing strict guidelines and recommendations is not possible. However, the learning points identified in this book provide evidence on ways to co-create better, more user-centric public services with and for older adults.
Benchmarking deep network architectures for ethnicity recognition using a new large face dataset
Authors: Greco Antonio , Percannella Gennaro , Vento Mario , Vigilante Vincenzo 
Published: September 2020

AbstractAlthough in recent years we have witnessed an explosion of the scientific research in the recognition of facial soft biometrics such as gender, age and expression with deep neural networks, the recognition of ethnicity has not received the same attention from the scientific community. The growth of this field is hindered by two related factors: on the one hand, the absence of a dataset sufficiently large and representative does not allow an effective training of convolutional neural networks for the recognition of ethnicity; on the other hand, the collection of new ethnicity datasets is far from simple and must be carried out manually by humans trained to recognize the basic ethnicity groups using the somatic facial features. To fill this gap in the facial soft biometrics analysis, we propose the VGGFace2 Mivia Ethnicity Recognition (VMER) dataset, composed by more than 3,000,000 face images annotated with 4 ethnicity categories, namely African American, East Asian, Caucasian Latin and Asian Indian. The final annotations are obtained with a protocol which requires the opinion of three people belonging to different ethnicities, in order to avoid the bias introduced by the well-known other race effect. In addition, we carry out a comprehensive performance analysis of popular deep network architectures, namely VGG-16, VGG-Face, ResNet-50 and MobileNet v2. Finally, we perform a cross-dataset evaluation to demonstrate that the deep network architectures trained with VMER generalize on different test sets better than the same models trained on the largest ethnicity dataset available so far. The ethnicity labels of the VMER dataset and the code used for the experiments are available upon request at https://mivia.unisa.it.
On games without approximate equilibria
Authors: Levy Yehuda John 
Published: September 2020

AbstractThis note shows that the work by Simon and Tomkowicz (Israel J Math 227(1):215–231, 2018) answers another outstanding open question in game theory in addition to the non-existence of approximate Harsányi equilibrium in Bayesian games: it shows that strategic form games with bounded and separately continuous payoffs need not possess approximate equilibria.
The utility of automated volume analysis of renal stones before and after shockwave lithotripsy treatment
Authors: Cui Helen Wei , Tan Tze Khiang , Christiansen Frederikke Eichner , Osther Palle Jörn Sloth , Turney Benjamin William 
Published: September 2020

AbstractThis study aimed to evaluate the additional utility of an automated method of estimating volume for stones being treated with shockwave lithotripsy (SWL) using computed tomography (CT) images compared to manual measurement. Utility was assessed as the ability to accurately measure stone burden before and after SWL treatment, and whether stone volume is a better predictor of SWL outcome than stone diameter. 72 patients treated with SWL for a renal stone with available CT scans before and after treatment were included. Stone axes measurement and volume estimation using ellipsoid equations were compared to volume estimation using software using CT textural analysis (CTTA) of stone images. There was strong correlation (r > 0.8) between manual and CTTA estimated stone volume. CTTA measured stone volume showed the highest predictive value (r2 = 0.217) for successful SWL outcome on binary logistic regression analysis. Three cases that were originally classified as ‘stone-free with clinically insignificant residual fragments’ based on manual axis measurements actually had a larger stone volume based on CTTA estimation than the smallest fragments remaining for cases with an outcome of ‘not stone-free’. This study suggests objective measurement of total stone volume could improve estimation of stone burden before and after treatment. Current definitions of stone-free status based on manual measurements of residual fragment sizes are not accurate and may underestimate remaining stone burden after treatment. Future studies reporting on the efficacy of different stone treatments should consider using objective stone volume measurements based on CT image analysis as an outcome measure of stone-free state.
The coarse-grained plaque: a divergent Aβ plaque-type in early-onset Alzheimer’s disease
Authors: Boon Baayla D. C. , Bulk Marjolein , Jonker Allert J. , Morrema Tjado H. J. , van den Berg Emma , Popovic Marko , Walter Jochen , Kumar Sathish , van der Lee Sven J. , Holstege Henne , Zhu Xiaoyue , Van Nostrand William E. , Natté Remco , van der Weerd Louise , Bouwman Femke H. , van de Berg Wilma D. J. , Rozemuller Annemieke J. M. , Hoozemans Jeroen J. M. 
Published: September 2020

Abstract
Alzheimer’s disease (AD) is characterized by amyloid-beta (Aβ) deposits, which come in myriad morphologies with varying clinical relevance. Previously, we observed an atypical Aβ deposit, referred to as the coarse-grained plaque. In this study, we evaluate the plaque’s association with clinical disease and perform in-depth immunohistochemical and morphological characterization. The coarse-grained plaque, a relatively large (Ø ≈ 80 µm) deposit, characterized as having multiple cores and Aβ-devoid pores, was prominent in the neocortex. The plaque was semi-quantitatively scored in the middle frontal gyrus of Aβ-positive cases (n = 74), including non-demented cases (n = 15), early-onset (EO)AD (n = 38), and late-onset (LO)AD cases (n = 21). The coarse-grained plaque was only observed in cases with clinical dementia and more frequently present in EOAD compared to LOAD. This plaque was associated with a homozygous APOE ε4 status and cerebral amyloid angiopathy (CAA). In-depth characterization was done by studying the coarse-grained plaque’s neuritic component (pTau, APP, PrPC), Aβ isoform composition (Aβ40, Aβ42, AβN3pE, pSer8Aβ), its neuroinflammatory component (C4b, CD68, MHC-II, GFAP), and its vascular attribution (laminin, collagen IV, norrin). The plaque was compared to the classic cored plaque, cotton wool plaque, and CAA. Similar to CAA but different from classic cored plaques, the coarse-grained plaque was predominantly composed of Aβ40. Furthermore, the coarse-grained plaque was distinctly associated with both intense neuroinflammation and vascular (capillary) pathology. Confocal laser scanning microscopy (CLSM) and 3D analysis revealed for most coarse-grained plaques a particular Aβ40 shell structure and a direct relation with vessels. Based on its morphological and biochemical characteristics, we conclude that the coarse-grained plaque is a divergent Aβ plaque-type associated with EOAD. Differences in Aβ processing and aggregation, neuroinflammatory response, and vascular clearance may presumably underlie the difference between coarse-grained plaques and other Aβ deposits. Disentangling specific Aβ deposits between AD subgroups may be important in the search for disease-mechanistic-based therapies.
Molecular characterization of CNS paragangliomas identifies cauda equina paragangliomas as a distinct tumor entity
Authors: Schweizer Leonille , Thierfelder Felix , Thomas Christian , Soschinski Patrick , Suwala Abigail , Stichel Damian , Wefers Annika K. , Wessels Lars , Misch Martin , Kim Hee-yeong , Jödicke Ruben , Teichmann Daniel , Kaul David , Kahn Johannes , Bockmayr Michael , Hasselblatt Martin , Younsi Alexander , Unterberg Andreas , Knie Bettina , Walter Jan , Al Safatli Diaa , May Sven-Axel , Jödicke Andreas , Ntoulias Georgios , Moskopp Dag , Vajkoczy Peter , Heppner Frank L. , Capper David , Hartmann Wolfgang , Hartmann Christian , von Deimling Andreas , Reuss David E. , Schöler Anne , Koch Arend 
Published: September 2020

AbstractParagangliomas/pheochromocytomas are rare neuroendocrine tumors that arise from the adrenal gland or ganglia at various sites throughout the body. They display a remarkable diversity of driver alterations and are associated with germline mutations in up to 40% of the cases. Comprehensive molecular profiling of abdomino-thoracic paragangliomas revealed four molecularly defined and clinically relevant subtypes. Paragangliomas of the cauda equina region are considered to belong to one of the defined molecular subtypes, but a systematic molecular analysis has not yet been performed. In this study, we analyzed genome-wide DNA methylation profiles of 57 cauda equina paragangliomas and show that these tumors are epigenetically distinct from non-spinal paragangliomas and other tumors. In contrast to paragangliomas of other sites, chromosomal imbalances are widely lacking in cauda equina paragangliomas. Furthermore, RNA and DNA exome sequencing revealed that frequent genetic alterations found in non-spinal paragangliomas—including the prognostically relevant SDH mutations—are absent in cauda equina paragangliomas. Histologically, cauda equina paragangliomas show frequently gangliocytic differentiation and strong immunoreactivity to pan-cytokeratin and cytokeratin 18, which is not common in paragangliomas of other sites. None of our cases had a familial paraganglioma syndrome. Tumors rarely recurred (9%) or presented with multiple lesions within the spinal compartment (7%), but did not metastasize outside the CNS. In summary, we show that cauda equina paragangliomas represent a distinct, sporadic tumor entity defined by a unique clinical and morpho-molecular profile.
Wall Shear Stress Topological Skeleton Independently Predicts Long-Term Restenosis After Carotid Bifurcation Endarterectomy
Authors: Morbiducci Umberto , Mazzi Valentina , Domanin Maurizio , De Nisco Giuseppe , Vergara Christian , Steinman David A. , Gallo Diego 
Published: September 2020

AbstractWall Shear Stress (WSS) topological skeleton, composed by fixed points and the manifolds linking them, reflects the presence of blood flow features associated to adverse vascular response. However, the influence of WSS topological skeleton on vascular pathophysiology is still underexplored. This study aimed to identify direct associations between the WSS topological skeleton and markers of vascular disease from real-world clinical longitudinal data of long-term restenosis after carotid endarterectomy (CEA). Personalized computational hemodynamic simulations were performed on a cohort of 13 carotid models pre-CEA and at 1 month after CEA. At 60 months after CEA, intima-media thickness (IMT) was measured to detect long-term restenosis. The analysis of the WSS topological skeleton was carried out by applying a Eulerian method based on the WSS vector field divergence. To provide objective thresholds for WSS topological skeleton quantitative analysis, a computational hemodynamic dataset of 46 ostensibly healthy carotid bifurcation models was considered. CEA interventions did not completely restore physiological WSS topological skeleton features. Significant associations emerged between IMT at 60 months follow-up and the exposure to (1) high temporal variation of WSS contraction/expansion (R2 = 0.51, p < 0.05), and (2) high fixed point residence times, weighted by WSS contraction/expansion strength (R2 = 0.53, p < 0.05). These WSS topological skeleton features were statistically independent from the exposure to low WSS, a previously reported predictor of long-term restenosis, therefore representing different hemodynamic stimuli and potentially impacting differently the vascular response. This study confirms the direct association between WSS topological skeleton and markers of vascular disease, contributing to elucidate the mechanistic link between flow disturbances and clinical observations of vascular lesions.
Perioperative Nonsteroidal Anti-Inflammatory Agents in the COVID-19 Orthopedic Patient
Authors: Wu Christopher L. , Jules-Elysee Kethy M. , Kirksey Meghan A. , Liguori Gregory A. 
Published: September 2020

Background SARS-CoV-2 infection can cause serious complications beyond lung injury and respiratory failure, including sepsis, cardiovascular injury, renal failure, coagulation abnormalities, and neurologic injury. Widely used medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) have been flagged as having the potential to cause harm in the context of COVID-19. It is unknown if the benefits of NSAID use in the orthopedic population will outweigh the potential risks of increased morbidity in COVID-19 orthopedic patients. Methods We conducted a narrative review of the use of NSAIDs in the orthopedic patient with COVID-19, focusing on the effects of NSAIDs on the inflammatory process, the role of NSAIDs in orthopedics, and the associations between NSAID use and complications of pneumonia. Results We found that it may be appropriate to consider NSAID use in otherwise healthy orthopedic patients with COVID-19 and significant pain. Conclusions In this context, we recommend that NSAIDs be used at the lowest effective dose for the shortest duration possible in orthopedic patients with COVID-19. However, pending further data and based on the concerns outlined in this review, we recommend avoiding NSAIDs in orthopedic patients with significant comorbidities and those who are undergoing major orthopedic surgery.
The complete characterization of tangram pentagons
Authors: Pohl Sarah Sophie , Richter Christian 
Published: September 2020

AbstractThe old Chinese puzzle tangram gives rise to serious mathematical problems when one asks for all tangram figures that satisfy particular geometric properties. All 13 convex tangram figures are known since 1942. They include the only triangular and all six quadrangular tangram figures. The families of all n-gonal tangram figures with $$n \ge 6$$

n
≥
6

are either infinite or empty. Here we characterize all 53 pentagonal tangram figures, including 51 non-convex pentagons and 31 pentagons whose vertices are not contained in the same orthogonal lattice.
Studies on Learning Effects of AR-Assisted and PPT-Based Lectures
Authors: Zhang Jia , Yen Shao-Hsuan , Liu Tzu-Chien , Sung Yao-Ting , Chang Kuo-En 
Published: September 2020

AbstractWhile common, computer presentations given during classroom lectures do not always improve learning effects; thus, this study incorporated three elements into technology-assisted classroom lectures: emphasis, augmentation, and integration. These three elements cannot be implemented simultaneously when using PowerPoint (PPT) presentations during classroom lectures. Therefore, the virtual and physical integration of augmented reality (AR) was employed to establish an assisted course lecturing tool for implementing these three elements. Teachers can refer to important content from textbooks (emphasis) while lecturing, and students can then use an AR device to scan the content and to call out related supplementary materials (augmentation) in facilitating their learning. These scanning and calling out functions of AR enable teachers to integrate technology-assisted tools with textbooks to enhance the effectiveness of classroom lectures. The pre- and posttest quasi-experimental research design was used to determine differences in the learning outcomes of two groups of AR-assisted and PPT-based course lectures. The experimental results indicate that the AR-assisted lecture was significantly more effective than the PPT-based lecture, and a similar result was obtained from a delayed test. According to interviews held with students, during the AR-assisted lecture, the students tended to focus on only one teaching medium and on the textbook content. By contrast, students of the PPT-based lecture became distracted while focusing on two different media sources simultaneously, resulting in the textbook content often being neglected.
A survey on de novo assembly methods for single‐molecular sequencing
Authors: Chen Ying , Xiao Chuan‐Le 
Published: September 2020

BackgroundThe single‐molecular sequencing (SMS) is under rapid development and generating increasingly long and accurate sequences. De novo assembly of genomes from SMS sequences is a critical step for many genomic studies. To scale well with the developing trends of SMS, many de novo assemblers for SMS have been released. These assembly workflows can be categorized into two different kinds: the correction‐and‐assembly strategy and the assembly‐and‐correction strategy, both of which are gaining more and more attentions.ResultsIn this article we make a discussion on the characteristics of errors in SMS sequences. We then review the currently widely applied de novo assemblers for SMS sequences. We also describe computational methods relevant to de novo assembly, including the alignment methods and the error correction methods. Benchmarks are provided to analyze their performance on different datasets and to provide use guides on applying the computation methods.ConclusionWe make a detailed review on the latest development of de novo assembly and some relevant algorithms for SMS, including their rationales, solutions and results. Besides, we provide use guides on the algorithms based on their benchmark results. Finally we conclude the review by giving some developing trends of third generation sequencing (TGS).
Mechanisms and Consequences of Anthropomorphizing Autonomous Products
Authors: Jörling Moritz , Böhm Robert , Paluch Stefanie 
Published: September 2020

AbstractIn the present research, we test the mechanisms (Studies 1a and 1b, conducted online), consequences, and limitations (Study 2, conducted in the lab) of anthropomorphizing autonomous (vs. manual) products. Building on previous theoretical and empirical research on product anthropomorphism, we argue and find that anthropomorphism is perceived to be more congruent with autonomous products than with manual products. Furthermore, we show that anthropomorphism increases the liking of autonomous products, given that consumers have no prior experience with autonomous products. Increased liking of autonomous products due to anthropomorphism, in turn, increases purchase intentions and positive evaluations of outcomes obtained by the autonomous product. The findings are discussed with regard to optimal marketing and design of autonomous products.
Cognitive Enhancement of Sport Technique Learning by Sleep: A Systematic Review
Authors: Cicchella Antonio 
Published: September 2020

Abstract
Purpose
The importance of sleep in enhancing the consolidation of memory for movements has been demonstrated. A possible application of sleep manipulation to sport techniques learning is also potentially helpful for training.

Method
Eligibility criteria encompass the group of studies (cross-sectionals and interventions) on humans correlating sleep with physical performance. A search on the topic was performed in Medline.

Results
After a review of sleep organization and memory systems, an overview of literature specific to learning and sport performance is presented. Building on existing literature, it was found that, in the short period after awakening from a night deprived of sleep, a strong activation of CNS happens possibly due to increased catecholamines secretions. This is thought to benefit performance in sports of short duration where the nervous component is predominant, such as jumping and sprinting. On the contrary, complex cognitive tasks performed in sports such as tennis are instead impaired by sleep deprivation. The same applies for maximal performance in endurance running and weightlifting. Placement of a cognitive challenging training before sleep can therefore benefit the acceleration of the learning process of a novel motor task.

Conclusion
Cognitive and emotionally challenging tasks promote an increase of deep sleep, due to the stress put on the brain during learning. In conclusion, practice and/or rehearsal of complex techniques before sleep appears to accelerate the learning process, increasing accuracy and decreasing error rate. However, few studies exist on specific sport techniques, and further research is needed.
Impact of Magnetic Resonance Imaging (MRI) Findings on Management of Symptomatic Patients Following Radiofrequency Ablation (RFA) of Osteoid Osteoma (OO)
Authors: Maybody Majid , Soliman Mohamed M. , Hwang Sinchun , Gonzalez-Aguirre Adrian , Santos Martin Ernesto G. , Kaye Elena , Hsu Meier , Moskowitz Chaya , Healey John H. , Fabbri Nicola 
Published: September 2020

AbstractThe purpose of this study is to assess the impact of MRI findings on management of symptomatic patients following RFA of OO. Retrospective review of 43 patients with RFA for OO between June 2010 and June 2017 was performed. Patient, nidus, and ablation data were reviewed. Pre- and 6–8 weeks post-procedural MRI (n = 32) were compared for coverage of nidus by ablation zone, bone marrow edema, nidus hyperintensity, and other findings. Baseline pain levels and analgesic use were compared with post-procedural follow-up visit at 6–8 weeks. Three groups of clinical and MRI outcomes of complete (CR), partial (PR), and no response (NR) were defined. A weighted kappa statistic was used to assess for agreement. Clinical responses were CR in 34/43 (79.1%, 95% CI: 64.0–90.0%), PR in 8/43 (18.6%), and NR in 1/43 (2.3%) patients. All 19/32 patients with MRI CR experienced clinical CR. One patient with MRI NR had clinical NR. All 7/32 patients with clinical PR had MRI PR. All 4/43 complications were in MRI PR or NR groups. Substantial agreement was observed between MRI and clinical outcomes (kappa: 0.69, 95% CI: 0.45–0.95). MRI helped determine etiologies in all symptomatic patients and their management (n = 8). MRI is recommended for symptomatic patients after ablation.