bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the Italian version of the Revised Prenatal Coping Inventory (NuPCI) and its correlations with Pregnancy-Specific Stress.
Authors: Penengo Chiara , Colli Chiara , Garzitto Marco , Driul Lorenza , Cesco Maddalena , Balestrieri Matteo 
Published: July 2020

Abstract
Background: Pregnancy is a period of happiness but also of physical and psychological changes that can lead to distress. Functional coping strategies can reduce the pregnancy specific-stress. This study aimed to assess the psychometric properties of the Revised Prenatal Coping Inventory (NuPCI) in an Italian sample and to investigate how coping strategies were associated with pregnancy-specific stress.Methods: In this cross-sectional study, low-risk pregnant women (N=211) were assessed with NuPCI, NuPDQ (Revised-Prenatal Distress Questionnaire), Brief-COPE (Coping Orientation to the Problems Experienced), and STAI (State-Trait Anxiety Inventory). The reliability of NuPCI was evaluated by assessing its internal consistency and factor structure. The concurrent validity between NuPCI and Brief-COPE and NuPDQ and STAI was investigated. Lastly, the relationship between NuPCI and NuPDQ was analyzed, as well as the ability of these scales to predict Apgar score at birth.Results: Internal consistency of NuPCI scales was good for Planning-Preparation (ɑC=0.84) and Spiritual-Positive Coping (ɑC=0.81), acceptable for Avoidance (ɑC=0.76). The original three-factor structure was confirmed, using a promax solution. NuPCI and NuPDQ showed good concurrent validity. The NuPCI scales predicted NuPDQ score (Avoidance and Planning-Preparation positively, Spiritual-Positive Coping negatively). Also, Avoidance and Spiritual-Positive Coping scales were associated respectively to decreasing and to increasing Apgar score, with the moderation of NuPDQ.Conclusions: Italian NuPCI has sound psychometric properties and it is a useful coping measure. NuPDQ showed also a good validity. Our results may suggest a significant role for coping strategies, particularly in modulating the condition of the newborn at birth.
VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, induces cell cycle arrest and apoptosis in breast cancer cells by inhibiting the Wnt/β-catenin pathway
Authors: Li Hongling , Dang Chunyan , Tai Xiaohui , Xue Li , Meng Yuna , Ma Shuping , Zhang Jing 
Published: July 2020

Abstract
Background: Schiff base compounds and their metal complexes have become important synthetic organic drugs due to their extensive biological activities, which include anticancer, antibacterial and antiviral effects. In this study, we investigated the cytotoxic and apoptotic effects of VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, on human breast cancer cells and the possible underlying mechanisms.Methods: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)-test was used to observe the proliferation of human breast cancer MCF-7 and MDA-MB-231 cells induced on VALD-3. The effects of VALD-3 on the cell cycle were analyzed in MCF-7 and MDA-MB-231 cells by PI single staining. Hoechst 33258 staining was performed to determine if VALD-3 induced apoptosis of MCF-7 and MDA-MB-231 cells and Annexin V/PI staining was performed to quantify the percentages of apoptosis. The expression of pro-apoptotic proteins and anti-apoptotic proteins in MCF-7 and MDA-MB-231 cells was investigated by Western blotting. Wnt/β-catenin signaling pathways were also examined. The antitumor activity and survival analysis of VALD-3 in vivo was determined by the nude mice xenograft assay.Results: Flow cytometry analysis showed that VALD-3 triggered cell cycle arrest and induced apoptosis of breast cancer cells. Western blot analysis revealed that VALD-3 upregulated pro-apoptotic proteins (Bad and Bax), downregulated anti-apoptotic proteins (Bcl-2, Bcl-xl, survivin and XIAP) and increased the expression of cleaved caspase-3, cleaved caspase-8, Cyto-c and cleaved PARP. VALD-3 also regulated the Wnt/β-catenin signaling pathway in breast cancer cells, inhibiting the activation of downstream molecules. By xenografting human breast cancer cells into nude mice, we found that VALD-3 significantly suppressed tumor cell growth while showing low toxicity against major organs. In addition, survival analysis results showed that VALD-3 can significantly prolong the survival time of mice (P=0.036).Conclusion: This study is the first to show that VALD-3 induces apoptosis and cell cycle arrest in human breast cancer cells by suppressing Wnt/β-catenin signaling, indicating that it could be a potential drug for the treatment of breast cancer.
Prognostic value of a five-lncRNA signature in esophageal squamous cell carcinoma
Authors: Zhang Lan , Li Pan , Liu Enjie , Xing Chenju , Zhu Di , Zhang Jianying , Wang Weiwei , Jiang Guozhong 
Published: July 2020

Abstract
Background: The aim of this study was to identify prognostic long non-coding RNAs (lncRNAs) and develop a multi-lncRNA signature for suvival prediction in esophageal squamous cell carcinoma (ESCC). Methods: The clinical and gene expression data from Gene Expression Omnibus database (GSE53624, n=119) were obtianed as training set. A total of 98 paired ESCC tumor and normal tissues were detected by RNA sequencing and used as test set. Another 84 ESCC tissues were used for real-time quantitative PCR(qRT-PCR) and as an independent validation cohort. Survival analysis, Cox regression and Kaplan–Meier analysis were performed. Results: We screened a prognostic marker of ESCC from the GSE53624 dataset and named it as the five-lncRNA signature including AC007179.1, MORF4L2-AS1, RP11-488I20.9, RP13-30A9.2, RP4-735C1.6, which could classify patients into high- and low-risk groups with significantly different survival(median survival: 1.75 years vs. 4.01 years, log rank P<0.05). Then test dataset and validation dataset confirmed that the five-lncRNA signature can determine the prognosis of ESCC patients. Predictive independence of the prognostic marker was proved by multivariable Cox regression analyses in the three datasets (P<0.05). In addition, the signature was found to be better than TNM stage in terms of prognosis. Conclusion: The five-lncRNA signature could be a good prognostic biomarker for ESCC patients and has important clinical value.
A Surgeon's Handedness in Direct Anterior Approach-Hip Replacement
Authors: Kong Xiangpeng , Yang Minzhi , Ong Alvin , Guo Renwen , Chen Jiying , Wang Yan , Chai Wei 
Published: July 2020

Abstract
Background: The impact of handedness on clinical outcomes was easily overlooked in hip replacement. This study aimed to find whether the component positioning and hip function were affected by the handedness in total hip arthroplasty (THA) through direct anterior approach (DAA). Methods: Total 102 patients who underwent bilateral DAA-THAs simultaneously between May 2016 and November 2018 in our institute were reviewed. All surgeries were operated by one right-handed surgeon. Their demographic, cup positioning, stem alignment, femoral stem fit, Harris hip score (HHS), intraoperative and postoperative complications were used to evaluate the role of handedness in DAA.Results: The inclination of left cups was significantly larger than that of right cups (42.61±7.32 vs 39.42±7.19, p=0.000). The stem fit of left femur was significantly larger than that of right femur (84.34±4.83 vs 82.81±6.07, p=0.043). No significant differences in safe zone ratio, HHS and complications between bilateral hips were found. Conclusions: A surgeon’s handedness had significant impact on cup’s inclination and femoral stem fit in DAA-THA. However, there were no significant differences of cup malpositioning, stem alignment, hip function scores and complications between bilateral DAA-THAs.
Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A2 and inflammatory cytokines in patients referred to coronary angiography
Authors: Khandouzi Nafiseh , Zahedmehr Ali , Nasrollahzadeh Javad 
Published: July 2020

Abstract
Background: The potential cardioprotective benefits of olive oil (OO) and canola oil (CO) consumption have been shown in some studies. The present study was conducted to compare the effects of CO and OO on plasma lipids, some inflammatory cytokines, and lipoprotein-associated phospholipase A2 (Lp-PLA2) mass and activity in patients undergoing coronary angiography. Methods: A randomized, controlled, parallel-arm, clinical trial involving 48 patients (44 men and 4 women, aged 57.63 ± 6.34 years) with at least one classic cardiovascular risk factor (hypertension, dyslipidemia, or diabetes) who referred to coronary angiography was performed. Patients were randomly divided into two groups and received 25 mL/day refined olive oil (n=24) or canola oil (n=24) for 6 weeks. Plasma lipids, some selected inflammatory markers, and Lp-PLA2 levels were measured at the baseline and after the intervention. Results: CO consumption produced a significant reduction in plasma Lp-PLA2 mass (-0.97 ± 1.84 vs. 0.34 ± 1.57 ng/mL, P = 0.008 for CO and OO, respectively), whereas the mean changes of Interleukine-6 concentration were significantly lower after OO consumption compared with CO (-9.46 ± 9.46 vs. -0.90 ± 6.80 pg/mL, P = 0.008 for OO and CO, respectively). After 6 weeks of intervention, no significant changes were observed in plasma Lp-PLA2 activity, complement C3, C4, and lipid profile in two intervention groups. Conclusions: Comparing the two vegetable oils in subjects with cardiovascular risk factors shows that consumption of olive oil is more effective in reducing the level of inflammatory cytokine Interleukine-6 whereas canola oil is more effective in lowering the level of Lp-PLA2, but, this finding should be interpreted with caution since the Lp-PLA2 activity did not change significantly.
Study on the derived based catalysts from Theobroma cacao pod husks for the conversion of beef tallow blend with waste used vegetable oil for fatty acid ethyl ester synthesis: burnt, submerged fermented, calcination, hybrid design, catalyst refining and reusability
Authors: FOLORUNSHO Adepoju TUNDE , Mayen Ibeh A , O Babatunde E , Jackson Asuquo A , C Eloboka 
Published: July 2020

Abstract
Billions of dollars paid by industries on catalysts used as feedstocks to obtain their end products are increasing at a geometrical rate, the report revealed that the global marketplace price of catalysts stood at USD 26.1 billion in 2019, and is anticipated to increase by 4% in 2020, and 4.5% progress rate in 2025. To salvage the world from extravagance spending, there is an urgent need for biomass wastes consideration and utilization. In this paper, three novel CaO-based catalysts derived from Theobroma cacao pod husks were tested based on efficacy for the production of biodiesel (fatty acid ethyl ester: FAEE) from the blend of beef tallow-waste use oil in the ratio of 5:95 (BTO5),10:90 (BTO10),15:85 (BTO15), 20:80 (BTO20),….., 95:5 (BTO95), respectively. Process optimization of the transesterification reaction was carried out using a hybrid design to determine the effects of catalyst on the FAEE yield. The efficiencies of the catalyst were tested via the refining and reusability test. Results revealed the oil blend ratio of BTO60: WUO40 sufficiently produced low viscous oil that was easily converted to biodiesel. Catalysts' characterization revealed the three catalysts produced high CaO-based of 68.20, 81.46, and 87.65 (wt.%), which accounted for the high yield of FAEEs. Mathematical optimization showed that the catalyst amount (F-value between 14159.69-3063.24 with P-value between 0.0053-0.0115), played the most significant role in oil conversion to biodiesel among the constraint factors considered (reaction time, catalyst amount, reaction temperature, and EtOH/OMR). Based on Box-Cox transformation, the values of the lambda obtained indicated a normal data results with an inverse function of Y2 and Y3 and normal function of Y3 for polynomial model accuracy. Optimum validated FAEEs yields of 92.81, 93.02, and 99.64 (%wt.), respectively, with high R2. The qualities of the FAEEs were within the standard specification and the produced catalysts can serve as feedstocks for industrial application.
Influence of Indications on Perinatal Outcomes After Radio Frequency Ablation in Complicated Monochorionic Pregnancies: A Retrospective Cohort Study
Authors: Wang Hongmei , Zhou Qian , Wang Xietong , Song Jia , Chen Pengzheng , Wang Yanyun , Li Lei , Li Hongyan 
Published: July 2020

Abstract
Background:Radiofrequency ablation (RFA) is recommended to prevent potential neurological injury or intrauterine foetal death (IUFD) of the co-twin(s) in complicated monochorionic (MC) pregnancies. However, the impacts of various indications on the pregnancy outcome following RFA remain undefined clearly. This study aimed to determine how the indications influence the perinatal outcomes in complicated MC pregnancies undergoing radiofrequency ablation.Methods:This was a retrospective cohort study performed in a single centre. All consecutive women treated with RFA between July 2011 and July 2019 were included. The adverse perinatal outcomes and the survival rate were analysed based on various indications. The continuous variables with and without normal distribution were compared between the groups using Student’s t-test and Mann–Whitney U test, respectively, and for categorical variables, Chi-square and Fisher’s exact tests were used. P < 0.05 indicated a significant difference.Results:We performed 272 RFA procedures in 268 complicated MC pregnancies, including 60 selective intrauterine growth restriction (sIUGR), 64 twin–twin transfusion syndrome (TTTS), 12 twin reversed arterial perfusion sequence (TRAPs), 66 foetal anomaly and 66 elective foetal reduction (EFR) cases. The overall survival rate of the co-twin was 201/272 (73.9%). The overall technical successful rate was determined at 201/263 (76.7%). The intrauterine foetal death (IUFD) rate in the co-twin was 20/272 (7.4%). The TTTS group had recorded the lowest survival rate (37/64, 57. 8%), and the survival rate significantly correlated with Quintero stages (P = 0.029). Moreover, the sIUGR III subgroup had a lower survival rate compared with sIUGR II (55.6%, versus 84.3%). The subgroup of foetal anomaly of gastroschisis or exomphalos had the highest IUFD rate (4/10, 40%), followed by sIUGR III (2/9, 22.2%) and dichorionic triamniotic (DCTA) subgroup (8/46, 17.9%). In EFR group, eight IUFD cases were all coming from the DCTA subgroup and received RFA before 17 weeks.Conclusions:The perinatal outcome of RFA was correlated with the indications, with the lowest survival rate in TTTS IV and the highest IUFD incidence in abdominal wall defect followed by sIUGR III. Elective RFA after 17 weeks may prevent IUFD in DCTA pregnancies.
Intracranial compliance concepts and assessment: A scoping review protocol
Authors: Russo Thiago , Ocamoto Gabriela , Zambetta Rafaella , Vilela Gustavo , Hayashi Cintya , Brasil Sérgio , Rabelo Nícollas , Spavieri Deusdedit 
Published: July 2020

Abstract
Background: Monitoring patients with acute brain injury is crucial in neurocritical care. Intracranial compliance (ICC) has been studied to complement the interpretation of intracranial pressure (ICP) and help the neurocritical care team to anticipate brain function deterioration. ICC has been found to be related to compensatory mechanisms that maintain the stability of ICP (e.g., the higher the compensation, the higher the compliance of intracranial content to adapt to changes in volume and pressure). However, ICC has not been properly translated to clinical practice and has remained a critical technology gap in clinical neuroscience. The objective of this study is to establish a protocol for a scoping review to map the key concepts of ICC in the literature. In addition, this study is designed to characterize the relationship between ICC and ICP, as well as systematically describe the outcomes that are used to assess ICC, considering both the invasive and noninvasive methods.Methods: The scoping review protocol will be conducted according to the Joanna Briggs Institute’s recommendation. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews will be followed. Animals and humans are considered as the population to be investigated. No age criteria or health condition will be considered. ICC, as well as the relationship between ICC and ICP, will be considered as a core concept in this review. Information will be screened based on the context of neurocritical care. Several databases (PubMed, CINAHL, Web of Science, EMBASE, Epistemonikos, Grey Literature Report, clinical trial registries, and Cochrane Clinical Trials) will be searched to identify literature using a combination of keywords and descriptors, and there will be no restriction on the time frame. Data will be extracted systematically by the research team and the results will be summarized.Discussion: No systematic review has mapped the concepts of ICC and its relationship with ICP. Providing the key concepts of ICC and the methods of assessment might show its possible applications in clinical practice and the gaps in research.Systematic review registration: Currently, scoping review protocols are not eligible for registration in the International Prospective Register of Systematic Review database.
High Place Phenomenon: Prevalence and Clinical Correlates in Two German Samples
Authors: Teismann Tobias , Brailovskaia Julia , Schaumburg Svenja , Wannemüller André 
Published: July 2020

Abstract
Background: The high place phenomenon, that is, a sudden urge to jump when in a high place, is an experience known to many people, that has rarely been studied. The present study aimed to assess the prevalence of the high place phenomenon in a non-clinical and a clinical German sample. Furthermore, clinical correlates of the experience were assessed. Methods: The study sample comprised 276 participants (67% female; Mage=32.08, SDage=10.73) who took part in an online assessment and 94 patients (73.4% female; Mage=49.26, SDage=13.32) suffering from clinically relevant fear of flying. Participants filled out questionnaires on experiences with the high place phenomenon, depression, anxiety, suicide ideation and anxiety sensitivity.Results: The high place phenomenon was known to nearly 60% of the online sample and to 45% of the patient sample. Suicide ideation as well as anxiety sensitivity were positively associated with experiences with the high place phenomenon in the online sample. Depression, anxiety and suicide ideation were unrelated to experiences with the phenomenon in the patient sample. Conclusion: The high place phenomenon is commonly reported by (lifetime/current) suicide ideators. However, it is also a common experience in individuals who have never suffered from suicide ideation. It is therefore cautioned not to interpret such experiences as an expression of a hidden death wish.
Dexmedetomidine Versus Midazolam on Cough and Recovery Quality After Partial and Total Laryngectomy – a Randomized Controlled Trial
Authors: Xu Rui , Zhu Yun , Lu Yi , Li Wen Xian , Jia Jie 
Published: July 2020

Abstract
Backgroundː During emergence from anesthesia after partial and total laryngectomy, excessive airway reflex and systemic hypertension may lead to pneumoderm, hemorrhage or pneumothorax. Methodsː ASA Ⅲ-Ⅳ male adults undergoing elective laryngectomy were recruited and randomly allocated to receive either dexmedetomidine or midazolam. The primary outcome was incidence and severity of cough. Pulse oximetry (SpO2 ), heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded. Visual Analogue Scale (VAS) and Ramsay sedation scale (RSS) were recorded at the point of awareness and departure from PACU. Rescue analgesia required consumption, time of spontaneous breath recovery, duration of the PACU stay, incidence of adverse effects were also recorded.Resultsː The prevalence of no coughing was significantly higher in group D than group M while the patients were at the point of awake and departure. Compared with group M, there was significant decrease in HR, SBP and DBP in group D than group M, and SpO2 was statistically significantly higher in group D than group M at the moment of laryngectomy. Pain scores were lower in group D than group M. The Ramsay score at awake in PACU was higher in group D than group M. There was no difference in time to spontaneous breathing recovery, duration of the PACU stayand incidence of adverse effects.Conclusionsː Compared with midazolam, dexmedetomidine is an effective alternative to attenuate coughing and hemodynamic changes with low incidence of adverse events during emergence for partial and total laryngectomy.Trial registration: NCT03918889, registered at clinicaltrials.gov, date of registration: March 28, 2019. Https://register.clinicaltrials.gov/prs/app/action/DownloadReceipt?uid=U0003V5T&ts=3&sid=S0008S19&cx=haixch
Triboelectric Touch Sensor for Position Mapping During Total Hip Arthroplasty
Authors: Jeong Jae Bum , Kim Hyeok , Yoo Jun-Il 
Published: July 2020

Abstract
Objective: In this research, a triboelectric nanogenerator (TENG) was utilized to determine if a pressure-based sensor could detect bearing friction in a total hip arthroplasty (THA) and detect the contact of specific areas during ROM checks. Results: The pressure-based sensor shows capability to sense bearing friction. In more detail, the TENG embedded in four different sides of the trial exhibits up to 1 V from peak-to-peak. Moreover, these flexible touch sensors with TENG describes a peak signal in output voltage which should lead to extremely sensitive detection of bearing friction induced by the THA.
Association of Gestational Diabetes Mellitus with Offspring Weight Status Across Infancy: A Prospective Birth Cohort Study in China
Authors: Hu Jiajin , Liu Yilin , Wei Xiaotong , Li Lin , Gao Ming , Liu Yang , Ma Yanan , Wen Deliang 
Published: July 2020

Abstract
Background: The association between gestational diabetes mellitus (GDM) and childhood body weight remains controversial, and additional study is needed, especially in Asian populations.Methods: This prospective study investigated the association between maternal glucose concentration, and GDM status and infant body weight from birth to 12 months of age. Linear mixed effects (LME) models and multiple linear regression were used to assess the longitudinal association of GDM with infant growth measured by weight-for-length (WFLZ), weight-for-age (WFAZ), and length-for-age (LFAZ) z-scores at birth, 1, 3, 6, 8, and 12 months of age.Results: Offspring born to mothers with GDM had higher WFLZ [β: 0.26 SD units (95% CI: 0.13–0.40)] across infancy than those of mothers without GDM. The association was more pronounced in normal-weight and overweight/obese women (P for interaction< 0.05). Multiple linear regression found that the effect estimate of GDM on infant WFLZ was highest at birth [β: 0.32 SD units (95% CI: 0.07– 0.57)], remained significant at 1 [β: 0.24 SD units (95% CI: 0.05–0.43)] and 3 [β:0.20 SD units (95% CI: 0.01–0.39)] months of age and decreased across infancy. Maternal GDM status were not associated with infant WFAZ or LFAZ.Conclusions: Maternal GDM status were associated with infant weight status, the association was more pronounced in normal-weight and overweight/obese women. The study results may contribute to the development interventions to prevent childhood obesity and to better define the target population.