bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional coronary angiography in symptomatic patients with no obstructive coronary artery disease
Authors: Kumar Sonali , Mehta Puja K. , Eshtehardi Parham , Hung Olivia Y. , Koh Jin‐Sin , Kumar Arnav , Al‐Badri Ahmed , Rabah Rani , D'Souza Melroy , Gupta Sonu , McDaniel Michael , Vaccarino Viola , Douglas John , Mavromatis Kreton , Lee Joo Myung , Quyyumi Arshed , Samady Habib 
Published: September 2020

AbstractBackgroundPatients without obstructive coronary artery disease (CAD) may have epicardial or microvascular dysfunction. The purpose of this study was to characterize patterns of epicardial and microvascular dysfunction in men and women with stable and unstable angina undergoing functional coronary angiography to inform medical therapy.Methods163 symptomatic patients with ≤50% diameter stenosis and fractional flow reserve (FFR) > 0.8 underwent endothelium‐dependent epicardial and microvascular function after intracoronary acetylcholine (10−4 M, 81 mcg over 3 minutes). Endothelium‐independent function was assessed using coronary flow reserve (CFR) and hyperemic microvascular resistance (HMR) after intravenous adenosine (140 ug/kg/min). Coronary microvascular dysfunction (CMD) was defined as CFR < 2.5, HMR ≥2, or ≤50% change in coronary blood flow with acetylcholine (CBFACH).ResultsSeventy‐two percent had endothelial‐dependent epicardial dysfunction (response to ACH: % ∆ in coronary artery diameter and ∆%CBFACH) and 92% had CMD. Among CMD patients, 65% had CFR < 2.5, 35% had HMR ≥2, and 60% had CBFACH change ≤50%. CFR modestly correlated with HMR (r = −0.38, p < .0001). Among patients with normal CFR, 26% had abnormal epicardial and 20% had abnormal microvascular endothelial dysfunction. Women had a lower CFR (p = .02), higher FFR (p = .03) compared to men. There were no differences in epicardial and microvascular function between patients with stable and unstable angina.ConclusionIn patients with no obstructive CAD: CMD is prevalent, abnormal CFR does not correlate with epicardial or microvascular endothelial dysfunction, women have lower CFR, higher FFR but similar endothelial function compared to men.
Cutting forces and crater wear prediction in orthogonal cutting using two approaches of finite element modeling
Authors: Soliman Hatem A. , Shash Ahmed Y. , El‐Hossainy Tarek M. , Abd‐Rabou Mahmoud 
Published: September 2020

AbstractThis work deals with plane strain finite element modeling for orthogonal cutting process of carbon steel. The experimental work conducted on a center lathe machine using carbide tools. The main objective was to simulate the cutting process by applying finite element method using computer software (Abaqus/CAE) to predict the cutting forces and crater wear. A comparative study was held between two modeling approaches; Lagrangian approach and Arbitrary Lagrangian‐Eulerian (ALE) approach in terms of force prediction, reading stability and chip form. The results demonstrate that ALE model is more accurate and stable than Lagrangian model, as well ALE chip form is smoother and more reliable. Johnson‐Cook (J‐C) models were utilized to define the plastic and damage properties for the tool and workpiece materials in the finite element program. Finally, this work adopted a methodology to predict crater wear experimentally by using profilometer device. On the other side, the crater wear was predicted from simulation by measuring the contact pressure on tool face. The agreement between the simulation and experimental wear results proves that the ALE model is capable to predict tool wear.
Maintaining SmartX multi‐view visibility for OF@TEIN+ distributed cloud‐native edge boxes
Authors: Rathore Muhammad Ahmad , Usman Muhammad , Kim JongWon 
Published: September 2020

AbstractMaintaining knowledge of infrastructure has always been a key element to ensure the performance of complex distributed systems, being the first step to control quality of service, identify key performance bottlenecks, or make decisions about resource allocation and job scheduling, to name a few. In cloud‐native edge boxes, edge computing leverages cloud‐native applications to process/analyze some of their computing/storage own close to the location where the data is generated by a large number of heterogeneous devices. Some of the differences between this approach and more conventional architecture, like cloud are that in a distributed environment, these resources/applications have varying running conditions depending on resource availability, quality of network connection, and being geo‐distributed. These aforementioned challenges in operations, however, contribute to a requirement toward identifying efficient methods for monitoring operational environment with continuity in order to maintain and sustain services. In this article, we present setup and configuration of distributed resources with cloud‐native edge capabilities and having centralized connectivity in a specialized multi‐site cloud testbed. Second, we propose a solution to persistently maintain multi‐view (ie, resource‐layer and flow layer) visibility data (monitoring) collection under varying situations and environments. Third, we present verification results on a prototype implementation and interactive visualization support. This solution allows maintaining monitoring visibility data that conform to the specific demands of cloud‐native edge computing resources. We evaluate the research by maintaining visibility data of multi‐site cloud at 14 research institutes for several months and we demonstrate that it fulfills the requirements we previously enumerated.
Responses to the primary health care needs of Aboriginal and Torres Strait Islander women experiencing violence: A scoping review of policy and practice guidelines
Authors: Walker Natasha , Mackean Tamara , Longbottom Marlene , Coombes Julieann , Bennett‐Brook Keziah , Clapham Kathleen , Ivers Rebecca , Hackett Maree , Redfern Julie , Cullen Patricia 
Published: September 2020

AbstractIssue addressedIt is demonstrated that primary health care (PHC) providers are sought out by women who experience violence. Given the disproportionate burden of violence experienced by Aboriginal and Torres Strait Islander women, it is essential there is equitable access to appropriate PHC services. This review aimed to analyse whether Australian PHC policy accounts for the complex needs of Aboriginal and Torres Strait Islander women experiencing violence and the importance of PHC providers responding to violence in culturally safe ways.MethodsUsing the Arskey and O’Malley framework, an iterative scoping review determined the policies for analysis. The selected policies were analysed against concepts identified as key components in responding to the needs of Aboriginal and Torres Strait Islander women experiencing violence. The key components are Family Violence, Violence against Aboriginal and Torres Strait Islander Women, Social Determinants of Aboriginal and Torres Strait Islander Health and Wellbeing, Cultural Safety, Holistic Health, Trauma, Patient‐Centred Care and Trauma‐and‐Violence‐Informed Care.ResultsFollowing a search of Australian government websites, seven policies were selected for analysis. Principally, no policy embedded or described best practice across all key components.ConclusionThe review demonstrates the need for a specific National framework supporting Aboriginal and Torres Strait Islander women who seek support from PHC services, as well as further policy analysis and review.So what?Aboriginal and Torres Strait Islander women disproportionately experience more severe violence, with complex impact, than other Australian women. PHC policy and practice frameworks must account for this, together with the intersection of contemporary manifestations of colonialism and historical and intergenerational trauma.
Prevention of noncommunicable diseases by interventions in the preconception period: A FIGO position paper for action by healthcare practitioners
Authors: Jacob Chandni Maria , Killeen Sarah Louise , McAuliffe Fionnuala M. , Stephenson Judith , Hod Moshe , Diaz Yamal Ivonne , Malhotra Jaideep , Mocanu Edgar , McIntyre H. David , Kihara Anne B. , Ma Ronald C. , Divakar Hema , Kapur Anil , Ferriani Rui , Ng Ernest , Henry Laurie , Van Der Spuy Zephne , Rosenwaks Zev , Hanson Mark A. 
Published: September 2020

AbstractWith the increase in obesity prevalence among women of reproductive age globally, the risks of type 2 diabetes, gestational diabetes, pre‐eclampsia, and other conditions are rising, with detrimental effects on maternal and newborn health. The period before pregnancy is increasingly recognized as crucial for addressing weight management and reducing malnutrition (both under‐ and overnutrition) in both parents to reduce the risk of noncommunicable diseases (NCDs) in the mother as well as the passage of risk to her offspring. Healthcare practitioners, including obstetricians, gynecologists, midwives, and general practitioners, have an important role to play in supporting women in planning a pregnancy and achieving healthy nutrition and weight before pregnancy. In this position paper, the FIGO Pregnancy Obesity and Nutrition Initiative provides an overview of the evidence for preconception clinical guidelines to reduce the risk of NCDs in mothers and their offspring. It encourages healthcare practitioners to initiate a dialogue on women’s health, nutrition, and weight management before conception. While acknowledging the fundamental importance of the wider social and environmental determinants of health, this paper focuses on a simple set of recommendations for clinical practice that can be used even in short consultations. The recommendations can be contextualized based on local cultural and dietary practices as part of a system‐wide public health approach to influence the wider determinants as well as individual factors influencing preconception health.
Modulation of antioxidant enzymes, SIRT1 and NF‐κB by resveratrol and nicotinamide in alcohol‐aflatoxin B1‐induced hepatocellular carcinoma
Authors: Rawat Divya , Chhonker Saurabh Kumar , Naik Rayees Ahmad , Koiri Raj Kumar 
Published: September 2020

AbstractHepatocellular carcinoma (HCC) is the fifth most commonly diagnosed cancer worldwide and is associated with poor prognosis. The current study aimed to assess the therapeutic efficacy of resveratrol when administered alone and in combination with nicotinamide against alcohol‐aflatoxin B1‐induced HCC. Results reveal that during the development and progression of cancer, there was a decline in the level of antioxidant enzymes catalase, glutathione peroxidase, glutathione reductase (GR), antioxidant glutathione, and glutathione S‐transferase, which is an enzyme of detoxification pathways. Treatment of resveratrol restored the level of catalase and glutathione peroxidase toward normal in alcohol‐aflatoxin B1‐induced HCC; however, nicotinamide worked in concert with resveratrol only in upregulating the activity of glutathione reductase, glutathione level, and glutathione S‐transferase. SIRT1 agonist resveratrol was observed to modulate the activity of antioxidant enzymes by negatively regulating the expression of nuclear factor‐κB (NF‐κB) in alcohol‐aflatoxin B1‐induced HCC, thereby suggesting a cross‐talk between antioxidant enzymes SIRT1 and NF‐κB during the development and progression of HCC and its therapeutics by resveratrol and nicotinamide.
Predictive criteria of severe cases in COVID‐19 patients of early stage: A retrospective observational study
Authors: Gao Jinrui , Huang Xiu , Gu Haibo , Lou Lingyun , Xu Zhihao 
Published: September 2020

AbstractBackgroundPatients with coronavirus disease 2019 (COVID‐19) often suffer sudden deterioration of disease around 1‐2 weeks after onset. Once the disease progressed to severe phase, clinical prognosis of patients will significantly deteriorate.MethodsThis was a multicenter retrospective study on patients of all adult inpatients (≥18 years old) from Tianyou Hospital (Wuhan, China) and the Fourth Affiliated Hospital, Zhejiang University School of Medicine. All 139 patients had laboratory‐confirmed COVID‐19 in their early stage, which is defined as within 7 days of clinical symptoms. Univariate and multivariate logistic regression models were used to determine the predictive factors in the early detection of patients who may subsequently develop into severe cases.ResultsMultivariable logistic regression analysis showed that the higher level of hypersensitivity C‐reactive protein (OR = 4.77, 95% CI:1.92‐11.87, P = .001), elevated alanine aminotransferase (OR = 6.87, 95%CI:1.56‐30.21, P = .011), and chronic comorbidities (OR = 11.48, 95% CI:4.44‐29.66, P < .001) are the determining risk factors for the progression into severe pneumonia in COVID‐19 patients.ConclusionEarly COVID‐19 patients with chronic comorbidities, elevated hs‐CRP or elevated ALT are significantly more likely to develop severe pneumonia as the disease progresses. These risk factors may facilitate the early diagnosis of critical patients in clinical practice.
The effect of various asthma medications on surface roughness of pediatric dental restorative materials: An atomic force microscopy and scanning electron microscopy study
Authors: Candan Merve , Ünal Murat 
Published: September 2020

AbstractThe aim of the study is to examine and compare the effects of various inhaled asthma medications (IAMs) on the surface roughness of dental restorative materials (DRMs). In total, 192 samples were prepared including 32 samples for the each material group from six different DRMs [Nanohybrid composite (Filtek Z550), Nanofilled flowable composite (Filtek Ultimate), Compomer (Dyract XP), Conventional glass ionomer (Fuji IX Fast), Resin‐modified glass ionomer (Fuji II LC), Self‐adhering flowable composite (Fusio Liquid Dentin)]. Each group, were divided into four subgroups (n = 8) according to four different IAMs. Surface roughness values (Ra) were obtained by atomic force microscopy (AFM). After the initial roughness of DRMs was analyzed by using AFM and scanning electron microscopy (SEM), each samples were exposed to the same IAMs for 21 days and all analysis were repeated on the 7th and 21st day. Ras increased in all DRMs and higher Ras were recorded through the long‐term IAMs administrations. For all IAMs, Fuji II LC had the highest Ra and Filtek Z550 had the lowest Ra. The combined IAM created the highest roughness change on the 7th and 21st day compared to other IAMs. As a result, in in vitro conditions IAMs significantly increased the surface roughness of DRMs.
Outcomes of bone marrow mononuclear cell transplantation combined with interventional education for autism spectrum disorder
Authors: Nguyen Thanh Liem , Nguyen Hoang-Phuong , Ngo Minh Duy , Bui Viet Anh , Dam Phuong T. M. , Bui Hoa Thi Phuong , Ngo Doan Van , Tran Kien Trung , Dang Tung Thi Thanh , Duong Binh Duc , Nguyen Phuong Anh Thi , Forsyth Nicholas , Heke Michael 
Published: September 2020

AbstractThe aim of this study was to evaluate the safety and efficacy of autologous bone marrow mononuclear cell transplantation combined with educational intervention for children with autism spectrum disorder. An open-label clinical trial was performed from July 2017 to August 2019 at Vinmec International Hospital, Hanoi, Vietnam. Thirty children who fulfilled the autism criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and had Childhood Autism Rating Scale (CARS) scores &gt;37 were selected. Bone marrow was harvested by anterior iliac crest puncture under general anesthesia. The volume collected was as follows: 8 mL/kg for patients under 10 kg (80 mL + [body weight in kg − 10] × 7 mL) for patients above 10 kg. Mononuclear cells were isolated with a Ficoll gradient and then infused intrathecally. The same procedure was repeated 6 months later. After the first transplantation, all patients underwent 8 weeks of educational intervention based on the Early Start Denver Model. There were no severe adverse events associated with transplantation. The severity of autism spectrum disorder (ASD) was significantly reduced, with the median CARS score decreasing from 50 (range 40-55.5) to 46.5 (range 33.5-53.5) (P &lt; .05). Adaptive capacity increased, with the median Vineland Adaptive Behavior Scales score rising from 53.5 to 60.5. Social communication, language, and daily skills improved markedly within 18 months after transplantation. Conversely, repetitive behaviors and hyperactivity decreased remarkably. Autologous bone marrow mononuclear cell transplantation in combination with behavioral intervention was safe and well tolerated in children with ASD (Trial registration: ClinicalTrials.gov identifier: NCT03225651).
Pointing Gesture Based User Interaction of Tool Supported Brainstorming Meetings
Authors: Dhingra Naina , Koutny Reinhard , Günther Sebastian , Miesenberger Klaus , Mühlhäuser Max , Kunz Andreas 
Published: September 2020

AbstractThis paper presents a brainstorming tool combined with pointing gestures to improve the brainstorming meeting experience for blind and visually impaired people (BVIP). In brainstorming meetings, BVIPs are not able to participate in the conversation as well as sighted users because of the unavailability of supporting tools for understanding the explicit and implicit meaning of the non-verbal communication (NVC). Therefore, the proposed system assists BVIP in interpreting pointing gestures which play an important role in non-verbal communication. Our system will help BVIP to access the contents of a Metaplan card, a team member in the brainstorming meeting is referring to by pointing. The prototype of our system shows that targets on the screen a user is pointing at can be detected with 80% accuracy.
Designing Nostalgic Tangible User Interface Application for Elderly People
Authors: Bong Way Kiat , Maußer Florian , van Eck Margot , De Araujo Diogo , Tibosch Jorg , Glaum Tobias , Chen Weiqin 
Published: September 2020

AbstractOur elderly population faces challenges in accepting and using new digital technology, and tangible user interface (TUI) can contribute as a more intuitive user interface in addressing these challenges. Studies have shown that nostalgic memories trigger positive emotions, which can provide better experiences for elderly people in learning and using new technology. However, the use of nostalgia in TUI for elderly people has been little and therefore the understanding on how nostalgia can contribute in TUI promoting technology acceptance among elderly people is limited. In order to address this knowledge gap, in this study we have created a nostalgic TUI application for elderly people through three iterations of design, development and evaluation. The results show that by adopting the element of nostalgia into the TUI application, elderly people could learn to use new technology in a more intuitive way. They could relate the new technology to their old positive memories. However, they had expectations that the TUI application would work exactly like the old fashioned way. Through the research process, we gathered and reflected on the lessons learned, which can serve as guidelines for using the concept of nostalgia in designing TUI application for elderly people’s technology acceptance.
On the UV completion of the O(N) model in 6 − ϵ dimensions: a stable large-charge sector
Authors: Arias-Tamargo G. , Rodriguez-Gomez D. , Russo J. G. 
Published: September 2020

Abstract
We study large charge sectors in the O(N) model in 6 − ϵ dimensions. For 4 < d < 6, in perturbation theory, the quartic O(N) theory has a UV stable fixed point at large N . It was recently argued that this fixed point can be described in terms of an IR fixed point of a cubic O(N) model. By considering a double scaling limit of large charge and weak couplings, we compute two-point and all “extremal” higher-point correlation functions for large charge operators and find a precise equivalence between both pictures. Instanton instabilities are found to be exponentially suppressed at large charge. We also consider correlation function of U(1)-invariant meson operators in the O(2N) ⊃ U(1) × SU(N) theory, as a first step towards tests of (higher spin) AdS/CFT.
Improving the understanding of jet grooming in perturbation theory
Authors: Larkoski Andrew J. 
Published: September 2020

Abstract
Jet grooming has emerged as a necessary and powerful tool in a precision jet physics program. In this paper, we present three results on jet grooming in perturbation theory, focusing on heavy jet mass in e+e−→ hadrons collisions, groomed with the modified mass drop tagger. First, we calculate the analytic cross section at leading-order. Second, using the leading-order result and numerical results through next-to-next-to-leading order, we show that cusps in the distribution on the interior of phase space at leading-order are softened at higher orders. Finally, using analytic and numerical results, we show that terms that violate the assumptions of the factorization theorem for groomed jet mass are numerically much smaller than expected from power counting. These results provide important information regarding the convergence of perturbation theory for groomed jet observables and reliable estimates for residual uncertainties in a precision calculation.
Impression material accuracy for palatal orthodontic miniscrews
Authors: Schenz Natalie , Schwarz Vincent , Hörmann Romed , Crismani Adriano G. 
Published: September 2020

Abstract
Purpose
This study investigates the accuracy of abutment transfer with current impression materials and provides a concise overview, including other relevant factors, in order to enable clinicians to make an informed decision about the optimal impression for this treatment procedure.

Methods
In all, 96 impressions of a cadaver head with two orthodontic miniscrews in place were taken with four common impression materials by two observers and using two methods of application. After pouring with a standard type IV stone and abutment transfer, all models and the upper jaw (which had been separated from the head) were scanned in a standard model scanner (Zirkonzahn® [Zirkohnzahn GmbH, Gais, Italy] S600 ARTI) and evaluated using a computer-aided design (CAD) program (GOM-Inspect [Gesellschaft für optische Messtechnik m.b.H., Braunschweig, Germany]). The deviations were measured at six points per screw and statistically evaluated with SPSS® (IBM, Chicago, IL, USA).

Results
Optimal values were obtained with biphasic polyvinylsiloxane, while monophasic polyvinylsiloxane, alginate and polyether also resulted in acceptable accuracy. Observer experience showed no effect and the method of application had only a minor effect on accuracy.

Conclusions
Within the limitations of this study, it seems that all impression materials are suitable for miniscrew abutment transfer, provided that methods of intraoral adaptation of the orthodontic appliance can be employed. If higher accuracy is needed or for clinicians with less experienced, a biphasic polyvinylsiloxane impression with the putty-wash technique should be used as this combination reduces setting time. The most cost-effective version, alginate, can be used if the consequences of greater deviations can be handled. Caution is advised with polyether if undercuts are present.
Akute partielle Okulomotoriusparese
Authors: Münden M. , Leivaditis V. , Comeau C. , Möllers M. , Hamelmann E. , Classen G. 
Published: September 2020

ZusammenfassungPräsentiert wird der Fall eines 8 Jahre alten Mädchens mit Schielen, Doppelbildern und Nystagmus bei akuter partieller Okulomotoriusparese. Auffällige MRT-Untersuchung mit zahlreichen intrakraniellen Veränderungen mit Dissemination in Raum und Zeit. In der Liquordiagnostik Nachweis intrathekaler Antikörpersynthese mit oligoklonalen Banden. Bei hochaktiver multipler Sklerose Beginn mit einer Steroidtherapie und darauffolgendem schnellen Symptomrückgang. Progress nach 3 Monaten bei Nichtbeginn der empfohlenen immunmodulierenden Therapie.