bluuebunny/crossref_metadata_2025_split huggingface dataset:
The nearby magnetic cool DZ white dwarf PM J08186−3110
Authors: Kawka Adela , Vennes Stéphane , Allard Nicole F , Leininger T , Gadéa F X 
Published: November 2020

ABSTRACT
We present an analysis of photometric, spectroscopic, and spectropolarimetric data of the nearby, cool, magnetic DZ white dwarf PM J08186−3110. High-dispersion spectra show the presence of Zeeman splitted spectral lines due to the presence of a surface average magnetic field of 92 kG. The strong magnesium and calcium lines show extended wings shaped by interactions with neutral helium in a dense, cool helium-rich atmosphere. We found that the abundance of heavy elements varied between spectra taken 10 years apart but we could not establish a time-scale for these variations; such variations may be linked to surface abundance variations in the magnetized atmosphere. Finally, we show that volume-limited samples reveal that about 40 per cent of DZ white dwarfs with effective temperatures below 7000 K are magnetic.
Striations, integrals, hourglasses, and collapse – thermal instability driven magnetic simulations of molecular clouds
Authors: Wareing C J , Pittard J M , Falle S A E G 
Published: November 2020

ABSTRACT
The MHD version of the adaptive mesh refinement (AMR) code, MG, has been employed to study the interaction of thermal instability, magnetic fields, and gravity through 3D simulations of the formation of collapsing cold clumps on the scale of a few parsecs, inside a larger molecular cloud. The diffuse atomic initial condition consists of a stationary, thermally unstable, spherical cloud in pressure equilibrium with lower density surroundings and threaded by a uniform magnetic field. This cloud was seeded with 10 per cent density perturbations at the finest initial grid level around n = 1.1 cm−3 and evolved with self-gravity included from the outset. Several cloud diameters were considered (100, 200, and 400 pc) equating to several cloud masses (17 000, 136 000, and 1.1 × 106 M⊙). Low-density magnetic-field-aligned striations were observed as the clouds collapse along the field lines into disc-like structures. The induced flow along field lines leads to oscillations of the sheet about the gravitational minimum and an integral-shaped appearance. When magnetically supercritical, the clouds then collapse and generate hourglass magnetic field configurations with strongly intensified magnetic fields, reproducing observational behaviour. Resimulation of a region of the highest mass cloud at higher resolution forms gravitationally bound collapsing clumps within the sheet that contain clump-frame supersonic (M ∼ 5) and super-Alfvénic (MA ∼ 4) velocities. Observationally realistic density and velocity power spectra of the cloud and densest clump are obtained. Future work will use these realistic initial conditions to study individual star and cluster feedback.
Demography of galactic technosignatures
Authors: Grimaldi Claudio 
Published: November 2020

ABSTRACT
Probabilistic arguments about the existence of technological life beyond Earth traditionally refer to the Drake equation to draw possible estimates of the number of technologically advanced civilizations releasing, either intentionally or not, electromagnetic emissions in the Milky Way. Here, we introduce other indicators than Drake’s number ND to develop a demography of artificial emissions populating the Galaxy. We focus on three main categories of statistically independent signals (isotropic, narrow beams, and rotating beacons) to calculate the average number NG of emission processes present in the Galaxy and the average number of them crossing Earth, $\bar{k}$, which is a quantity amenable to statistical estimation from direct observations. We show that $\bar{k}$ coincides with ND only for isotropic emissions, while $\bar{k}$ can be orders of magnitude smaller than ND in the case of highly directional signals. We further show that while ND gives the number of emissions being released at the present time, NG considers also the signals from no longer active emitters but whose emissions still occupy the Galaxy. We find that as long as the average longevity of the emissions is shorter than about 105 yr, NG is fully determined by the rate of emissions alone, in contrast to ND and $\bar{k}$ which depend also on the emission longevity. Finally, using analytic formulas of NG, ND, and $\bar{k}$ determined for each type of emission processes here considered, we provide a comprehensive overview of the values these quantities can possibly achieve as functions of the emission birthrates, longevities, and directionality.
The role of radiolysis in the modelling of C2H4O2 isomers and dimethyl ether in cold dark clouds
Authors: Paulive Alec , Shingledecker Christopher N , Herbst Eric 
Published: November 2020

ABSTRACT
Complex organic molecules (COMs) have been detected in a variety of interstellar sources. The abundances of these COMs in warming sources can be explained by syntheses linked to increasing temperatures and densities, allowing quasi-thermal chemical reactions to occur rapidly enough to produce observable amounts of COMs, both in the gas phase, and upon dust grain ice mantles. The COMs produced on grains then become gaseous as the temperature increases sufficiently to allow their thermal desorption. The recent observation of gaseous COMs in cold sources has not been fully explained by these gas-phase and dust grain production routes. Radiolysis chemistry is a possible non-thermal method of producing COMs in cold dark clouds. This new method greatly increases the modelled abundance of selected COMs upon the ice surface and within the ice mantle due to excitation and ionization events from cosmic ray bombardment. We examine the effect of radiolysis on three C2H4O2 isomers – methyl formate (HCOOCH3), glycolaldehyde (HCOCH2OH), and acetic acid (CH3COOH) – and a chemically similar molecule, dimethyl ether (CH3OCH3), in cold dark clouds. We then compare our modelled gaseous abundances with observed abundances in TMC-1, L1689B, and B1-b.
Gas-phase spectroscopic characterization of neutral and ionic polycyclic aromatic phosphorus heterocycles (PAPHs)
Authors: Oliveira Ricardo R , Molpeceres Germán , Fantuzzi Felipe , Quitián-Lara Heidy M , Boechat-Roberty Heloisa M , Kästner Johannes 
Published: November 2020

ABSTRACT
Polycyclic aromatic hydrocarbons (PAHs) constitute an essential family of compounds in interstellar (ISM) and circumstellar (CSM) media. Recently, formation routes for the corresponding polycyclic aromatic phosphorus heterocycles (PAPHs) in astrophysical environments have been proposed. In order to contribute to a better understanding of the phosphorus chemistry in the ISM, infrared (IR) spectra and selected properties of PAPHs were computed at the density functional theory level for neutral, cationic, and anionic species. Our results reveal that several protonated PAPHs do not have planar backbones, and all species have permanent dipole moments between 2D and 4D. Closed-shell PAPHs have similar ionization potentials compared to the parent PAHs, below the Lyman threshold limit. In addition, all PAPHs show positive electron affinities higher than those of PAHs. Protonation preferably occurs on the heteroatom but with lower proton affinities than those of the corresponding nitrogen analogues (polycyclic aromatic nitrogen heterocycles). In general, neutral species have similar IR spectra profile with the most intense bands around 800 cm−1 (12.5 μm) related to C−H wagging. Charge and protonation affect the IR spectra mainly by decreasing the intensities of these modes and increasing the ones between 1000 (10.0 μm) and 1800 cm−1 (5.6 μm). The P−H stretching appears in a different spectral region, between 2300 (4.3 μm) and 2700 cm−1 (3.7 μm). Our results are discussed in the context of distinct sources where PAHs and phosphorus are detected. PAPHs, in particular the coronene derivatives, can contribute to the unidentified infrared emission band at 6.2 μm.
A Sister Lineage of Sampled Retroviruses Corroborates the Complex Evolution of Retroviruses
Authors: Wang Jianhua , Han Guan-Zhu 
Published: November 2020

Abstract
The origin and deep history of retroviruses remain mysterious and contentious, largely because the diversity of retroviruses is incompletely understood. Here, we report the discovery of lokiretroviruses, a novel major lineage of retroviruses, within the genomes of a wide range of vertebrates (at least 137 species), including lampreys, ray-finned fishes, lobe-finned fishes, amphibians, and reptiles. Lokiretroviruses share a similar genome architecture with known retroviruses, but display some unique features. Interestingly, lokiretrovirus Env proteins share detectable similarity with fusion glycoproteins of viruses within the Mononegavirales order, blurring the boundary between retroviruses and negative sense single-stranded RNA viruses. Phylogenetic analyses based on reverse transcriptase demonstrate that lokiretroviruses are sister to all the retroviruses sampled to date, providing a crucial nexus for studying the deep history of retroviruses. Comparing congruence between host and virus phylogenies suggests lokiretroviruses mainly underwent cross-species transmission. Moreover, we find that retroviruses replaced their ribonuclease H and integrase domains multiple times during their evolutionary course, revealing the importance of domain shuffling in the evolution of retroviruses. Overall, our findings greatly expand our views of the diversity of retroviruses, and provide novel insights into the origin and complex evolutionary history of retroviruses.
High-resolution visualization and quantification of nucleic acid–based therapeutics in cells and tissues using Nanoscale secondary ion mass spectrometry (NanoSIMS)
Authors: He Cuiwen , Migawa Michael T , Chen Kai , Weston Thomas A , Tanowitz Michael , Song Wenxin , Guagliardo Paul , Iyer K Swaminathan , Bennett C Frank , Fong Loren G , Seth Punit P , Young Stephen G , Jiang Haibo 
Published: November 2020

Abstract
Nucleic acid therapeutics (NATs) have proven useful in promoting the degradation of specific transcripts, modifying gene expression, and regulating mRNA splicing. In each situation, efficient delivery of nucleic acids to cells, tissues and intracellular compartments is crucial—both for optimizing efficacy and reducing side effects. Despite successes in NATs, our understanding of their cellular uptake and distribution in tissues is limited. Current methods have yielded insights into distribution of NATs within cells and tissues, but the sensitivity and resolution of these approaches are limited. Here, we show that nanoscale secondary ion mass spectrometry (NanoSIMS) imaging can be used to define the distribution of 5-bromo-2′-deoxythymidine (5-BrdT) modified antisense oligonucleotides (ASO) in cells and tissues with high sensitivity and spatial resolution. This approach makes it possible to define ASO uptake and distribution in different subcellular compartments and to quantify the impact of targeting ligands designed to promote ASO uptake by cells. Our studies showed that phosphorothioate ASOs are associated with filopodia and the inner nuclear membrane in cultured cells, and also revealed substantial cellular and subcellular heterogeneity of ASO uptake in mouse tissues. NanoSIMS imaging represents a significant advance in visualizing uptake and distribution of NATs; this approach will be useful in optimizing efficacy and delivery of NATs for treating human disease.
COVID19 Drug Repository: text-mining the literature in search of putative COVID19 therapeutics
Authors: Tworowski Dmitry , Gorohovski Alessandro , Mukherjee Sumit , Carmi Gon , Levy Eliad , Detroja Rajesh , Mukherjee Sunanda Biswas , Frenkel-Morgenstern Milana 
Published: November 2020

AbstractThe recent outbreak of COVID-19 has generated an enormous amount of Big Data. To date, the COVID-19 Open Research Dataset (CORD-19), lists ∼130,000 articles from the WHO COVID-19 database, PubMed Central, medRxiv, and bioRxiv, as collected by Semantic Scholar. According to LitCovid (11 August 2020), ∼40,300 COVID19-related articles are currently listed in PubMed. It has been shown in clinical settings that the analysis of past research results and the mining of available data can provide novel opportunities for the successful application of currently approved therapeutics and their combinations for the treatment of conditions caused by a novel SARS-CoV-2 infection. As such, effective responses to the pandemic require the development of efficient applications, methods and algorithms for data navigation, text-mining, clustering, classification, analysis, and reasoning. Thus, our COVID19 Drug Repository represents a modular platform for drug data navigation and analysis, with an emphasis on COVID-19-related information currently being reported. The COVID19 Drug Repository enables users to focus on different levels of complexity, starting from general information about (FDA-) approved drugs, PubMed references, clinical trials, recipes as well as the descriptions of molecular mechanisms of drugs’ action. Our COVID19 drug repository provide a most updated world-wide collection of drugs that has been repurposed for COVID19 treatments around the world.
Renin–angiotensin system blocker discontinuation and adverse outcomes in chronic kidney disease
Authors: Walther Carl P , Winkelmayer Wolfgang C , Richardson Peter A , Virani Salim S , Navaneethan Sankar D 
Published: November 2020

Abstract

Background
Treatment with renin–angiotensin system inhibitors (RASIs), angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) is the standard of care for those with chronic kidney disease (CKD) and albuminuria. However, ACEI/ARB treatment is often discontinued for various reasons. We investigated the association of ACEI/ARB discontinuation with outcomes among US veterans with non-dialysis-dependent CKD.

Methods
We performed a retrospective cohort study of patients in the Veterans Affairs healthcare system with non-dialysis-dependent CKD who subsequently were started on ACEI/ARB therapy (new user design). Discontinuation events were defined as a gap in ACEI/ARB therapy of ≥14 days and were classified further based on duration (14–30, 31–60, 61–90, 91–180 and &gt;180 days). This was treated as a time-varying risk factor in adjusted Cox proportional hazards models for the outcomes of death and incident end-stage kidney disease (ESKD), which also adjusted for relevant confounders.

Results
We identified 141 252 people with CKD and incident ACEI/ARB use who met the inclusion criteria; these were followed for a mean 4.87 years. There were 135 356 discontinuation events, 68 699 deaths and 6152 incident ESKD events. Discontinuation of ACEI/ARB was associated with a higher risk of death [hazard ratio (HR) 2.3, 2.0, 1.99, 1.92 and 1.74 for those discontinued for 14–30, 31–60, 61–90, 91–180 and &gt;180 days, respectively]. Similar associations were noted between ACEI and ARB discontinuation and ESKD (HR 1.64, 1.47, 1.54, 1.65 and 1.59 for those discontinued for 14–30, 31–60, 61–90, 91–180 and &gt;180 days, respectively).

Conclusions
In a cohort of predominantly male veterans with CKD Stages 3 and 4, ACEI/ARB discontinuation was independently associated with an increased risk of subsequent death and ESKD. This may be due to the severity of illness factors that drive the decision to discontinue therapy. Further investigations to determine the causes of discontinuations and to provide an evidence base for discontinuation decisions are needed.
Subthalamic Nucleus Subregion Stimulation Modulates Inhibitory Control
Authors: van Wouwe Nelleke C , Neimat Joseph S , van den Wildenberg Wery P M , Hughes Shelby B , Lopez Alexander M , Phibbs Fenna T , Schall Jeffrey D , Rodriguez William J , Bradley Elise B , Dawant Benoit M , Wylie Scott A 
Published: November 2020

AbstractPatients with Parkinson’s disease (PD) often experience reductions in the proficiency to inhibit actions. The motor symptoms of PD can be effectively treated with deep brain stimulation (DBS) of the subthalamic nucleus (STN), a key structure in the frontal–striatal network that may be directly involved in regulating inhibitory control. However, the precise role of the STN in stopping control is unclear. The STN consists of functional subterritories linked to dissociable cortical networks, although the boundaries of the subregions are still under debate. We investigated whether stimulating the dorsal and ventral subregions of the STN would show dissociable effects on ability to stop. We studied 12 PD patients with STN DBS. Patients with two adjacent contacts positioned within the bounds of the dorsal and ventral STN completed two testing sessions (OFF medication) with low amplitude stimulation (0.4 mA) at either the dorsal or ventral contacts bilaterally, while performing the stop task. Ventral, but not dorsal, DBS improved stopping latencies. Go reactions were similar between dorsal and ventral DBS STN. Stimulation in the ventral, but not dorsal, subregion of the STN improved stopping speed, confirming the involvement of the STN in stopping control and supporting the STN functional subregions.
Isothiocyanate Derivatives of Glucosinolates as Efficient Natural Fungicides
Authors: Dubey Sylvain , Guignard Florian , Pellaud Sébastien , Pedrazzetti Matteo , van der Schuren Alja , Gaume Alain , Schnee Sylvain , Gindro Katia , Dubey Olga 
Published: November 2020

Fungal pathogens on crops account for losses that exceed US$200 billion annually. At present, chemical fungicides are widely used in the agricultural industry. Many of these products have a detrimental effect on human and animal health and are consequently forbidden postharvest, especially in Europe. Despite efforts to develop natural crop protection, very few have been commercialized. We explored the physicochemical characteristics of (i) glucosinolate derivatives from the present study and previously published papers in the light of their known biological roles and (ii) fungitoxic glucosinolate derivatives compared with natural and chemical fungicides. We found that 13 out of 31 tested natural and semisynthetic isothiocyanates are efficient fungicides against widespread species of plant pathogens alone and in a synergistic manner. Interestingly, physicochemical characteristics of fungitoxic glucosinolate derivatives differ from those showing no activities or known for their insecticidal or insect-attractive properties. The comparison of physicochemical characteristics of natural and semisynthetic fungitoxic glucosinolate derivatives with other fungicides (natural, semisynthetic, and synthetic) revealed that isothiocyanate glucosinolate derivatives clustered with nonglucosinolate derivatives plant fungicides as well as with some synthetic ones. Most of the fungicides show high bioaccumulation potential and lipophilic properties that most likely allow them to go through membranes. [Formula: see text] Copyright © 2021 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Evaluating the Relationship of Intraocular Pressure and Anterior Chamber Volume With Use of Prostaglandin Analogues
Authors: Scott Jessica A. , Roberts Cynthia J. , Mahmoud Ashraf M. , Jain Shelly Gupta 
Published: November 2020

Précis:
In this prospective study, naive prostaglandin use in primary open-angle glaucoma was associated with scleral biomechanical alteration and intraocular pressure (IOP) measuring errors.

Purpose:
The purpose of this study is to determine the effects of naïve use of prostaglandin analogues (PGA) on IOP and anterior chamber volume (ACV), as well as investigate how PGAs might affect corneal and scleral stiffness and their impact on ocular rigidity.

Materials and Methods:
This study was a prospective study of 21 recently diagnosed open-angle glaucoma patients (33 eyes) initiating medical therapy with a topical prostaglandin eye drop. Corneal morphologic and biomechanical parameters as well as IOP were measured at 3 visits over a 4-month period with the following equipment: Pentacam, Corvis ST, Ocular Response Analyzer, Goldmann applanation tonometry (GAT) and Pascal dynamic contour tonometry.

Results:
The study demonstrated a significant decrease in mean IOP with initiation of PGA in all 4 tonometers (P<0.0001). The greatest change in IOP occurred in the first 4 weeks of treatment (P<0.0001). The mean ACV showed a significant decrease at visit 2 (P<0.02) and visit 3 (P<0.04) compared with baseline visit 1. However, there was a paradoxical increase in ACV in 37% of eyes at visit 2, despite a significant mean reduction in IOP by GAT and dynamic contour tonometry.
The IOP/ACV ratio at visit 1 significantly predicted the reduction in respective measures of IOP, as well as scleral stiffness measured by stiffness parameter-highest concavity.

Conclusion:
In clinical practice, GAT may not be the most appropriate tonometer for measuring IOP in PGA treated eyes due the measurement errors from ocular biomechanical alteration. The IOP/ACV ratio could potentially serve as a new diagnostic parameter to determine the likelihood of PGA treatment success.
Recovery and Quality of Life After Trauma: A 6-Month Follow-Up Study
Authors: Nasirian Sara , Engström My , Forsberg Anna , Fagevik Olsén Monika 
Published: November 2020

Background:
Injuries were the most common cause of hospitalization in Sweden in 2017. There is a lack of knowledge about trauma recovery and its relation to health-related quality of life (HRQoL) after hospitalization due to minor trauma. This study aimed to prospectively evaluate recovery and HRQoL at discharge from hospital and 3 and 6 months after the trauma.

Methods:
This is a secondary analysis of data from a prospective follow-up study. Fifty-seven patients who sustained physical trauma were included. Recovery was measured with postoperative recovery profile and HRQoL 3 and 6 months after discharge. The association between the outcomes was analyzed, as well as the impact of gender, age, Injury Severity Score (ISS), and trauma mechanism using nonparametric statistics.

Results:
There was a significant improvement in recovery and HRQoL between discharge and 3 months after the trauma (p < .001) as well as between 3 and 6 months after the trauma (p < .001) except for EQ-5D VAS scale (p = .222). However, only 14 (25%) patients viewed themselves as fully recovered 6 months after the incident. Correlation between recovery and HRQoL increased after discharge and was at its strongest 6 months after the trauma (r
s > .071).

Conclusion:
Trauma mechanism has an impact on recovery but not gender, age, or ISS score. Most patients did not consider themselves fully recovered even at 6 months postinjury, indicating that they require additional support to manage their recovery.
A Guide to Academic Crisis Response
Authors: Hayes Rose , McCauley Linda 
Published: November 2020

Background
COVID-19 has tested the capacity of every nursing school, but its impact has varied according to the size, location, and baseline infrastructure of each school. This makes the pandemic an important lens through which to study crisis management principles, such as flexibility and scalability (the ability to expand and reduce efforts based on situational demands).

Purpose
This article provides a roadmap for academic crisis management, modeled on the National Incident Management System (NIMS). It is tailored to the unique needs of nursing schools and applies COVID-19 as a case study.

Methods
The authors explore the elements of the NIMS that were deployed within 1 top-ranked school of nursing during COVID-19.

Results and Conclusions
The article includes best practices, tips, and resources to help academic nurse leaders and educators navigate large-scale or unprecedented crises, such as COVID-19.