bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sociodemographic correlates of occupational, recreational and firearm noise exposure among adults in the USA
Authors: Knewitz A P , Simpson M C , Harris D A , Sappington J M , Osazuwa-Peters N 
Published: February 2020

AbstractObjectiveTo determine sociodemographic factors associated with occupational, recreational and firearm-related noise exposure.MethodsThis nationally representative, multistage, stratified, cluster cross-sectional study sampled eligible National Health and Nutrition Examination Survey participants aged 20–69 years (n = 4675) about exposure to occupational and recreational noise and recurrent firearm usage, using a weighted multivariate logistic regression analysis.ResultsThirty-four per cent of participants had exposure to occupational noise and 12 per cent to recreational noise, and 13 per cent repeatedly used firearms. Males were more likely than females to have exposure to all three noise types (adjusted odds ratio range = 2.63–14.09). Hispanics and Asians were less likely to have exposure to the three noise types than Whites. Blacks were less likely than Whites to have occupational and recurrent firearm noise exposure. Those with insurance were 26 per cent less likely to have exposure to occupational noise than those without insurance (adjusted odds ratio = 0.74, 95 per cent confidence interval = 0.60–0.93).ConclusionWhites, males and uninsured people are more likely to have exposure to potentially hazardous loud noise.
US toddler milk sales and associations with marketing practices
Authors: Choi Yoon Y , Ludwig Alexis , Harris Jennifer L 
Published: February 2020

AbstractObjective:Extensive marketing of ‘toddler milks’ (sugar-sweetened milk-based drinks for toddlers) promotes unsubstantiated product benefits and raises concerns about consumption by young children. The present study documents trends in US toddler milk sales and assesses relationships with brand and category marketing.Design:We report annual US toddler milk and infant formula sales and marketing from 2006 to 2015. Sales response models estimate associations between marketing (television advertising spending, product price, number of retail displays) and volume sales of toddler milks by brand and category.Setting:US Nielsen retail scanner sales and advertising spending data from 2006 to 2015.Participants:Researchers analysed all Universal Product Codes (n 117·4 million) sold by seven infant formula and eight toddler milk brands from 2006 to 2015.Results:Advertising spending on toddler milks increased fourfold during this 10-year period and volume sales increased 2·6 times. In contrast, advertising spending and volume sales of infant formulas declined. Toddler milk volume sales were positively associated with television advertising and retail displays, and negatively associated with price, at both the brand and category levels.Conclusions:Aggressive marketing of toddler milks has likely contributed to rapid sales increases in the USA. However, these sugar-sweetened drinks are not recommended for toddler consumption. Health-care providers, professional organizations and public health campaigns should provide clear guidance and educate parents to reduce toddler milk consumption and address misperceptions about their benefits. These findings also support the need to regulate marketing of toddler milks in countries that prohibit infant formula marketing to consumers.
The impact of replacing breakfast grains with meat/meat alternatives: an evaluation of child nutrition policy
Authors: Hanson Jennifer A , Cantrell Olivia , Paez Paola , Brenes Priscilla , Laursen Denise E 
Published: February 2020

AbstractObjective:To evaluate the Child and Adult Care Food Program (CACFP) rule that allows a meat/meat alternative to replace the breakfast grain requirement three times per week.Design:A 5-week menu including breakfast, lunch and snack was developed with meat/meat alternative replacing the breakfast grain requirement three times per week. Menu nutrients based on the minimum requirements were compared with reference values representing the Acceptable Macronutrient Distribution Range for fat and a range of reference values representing two-thirds the Dietary Reference Intake for 3-year-olds and 4–5-year-olds. The meal pattern minimum requirements were compared with two-thirds of those recommended by the Dietary Guidelines for Americans (DGA).Setting:Evaluation took place between April and June 2019.Participants:Human subjects were not utilized.Results:The CACFP minimum grain requirement is well below the DGA reference value (0·5–1·5 v. 3·33 ounce-equivalents). Energy (2208·52 kJ) was below the reference values (3126·83–4362·53 kJ). Protein (34·43 g) was above the reference values (9·87–10·81 g). Carbohydrate (76·65 g), fibre (7·46 g) and vitamin E (1·69 mg) were below their reference values of 86·67 g, 10·46–14·60 g and 4–4·76 mg, respectively. Fat (22·57 %) was below the reference range (25–40 %).Conclusions:The CACFP rule which allows a meat/meat alternative to replace the breakfast grain requirement three times per week may result in meal patterns low in energy, carbohydrate, fat, fibre and vitamin E, while providing an excessive amount of protein.
Origin and Accumulation of an Anthropogenic CO2 and 13C Suess Effect in the Arctic Ocean
Authors: Ko Young Ho , Quay Paul D. 
Published: February 2020

AbstractWe determined the impact of anthropogenic CO2 (Cant) accumulation on the δ13C of dissolved inorganic carbon in the Arctic Ocean (i.e., the 13C Suess effect) based on δ13C measurements during a GEOTRACES cruise in 2015. The δ13C decrease was estimated from the amount of Cant change derived by the transit time distribution approach and the ratio of the anthropogenic δ13C/dissolved inorganic carbon change (RC). A significant Cant increase (up to 45 μmol kg−1) and δ13C decrease (up to −0.9‰) extends to ~2,000 m in the Canada and Makarov Basin. We find distinctly different RC values for the intermediate water (300–2,000 m) and upper halocline water (<200 m) of −0.020 and −0.012‰ (μmol kg−1)−1, respectively, which identifies two sources of Cant accumulation from North Atlantic and North Pacific. Furthermore, estimated RC for intermediate waters is the same as the RC observed in the Greenland Sea and the rate of anthropogenic dissolved inorganic carbon increase estimated for intermediate waters at 0.9 μmol kg−1 yr−1 is identical to the estimated rate in the Iceland Sea. These observations indicate that the high rate of Cant accumulation and δ13C decrease in the Arctic Ocean is primarily a result of the input of Cant, via ventilation of intermediate waters, from the Nordic Sea rather than local anthropogenic CO2 uptake within the Arctic Basin. We determine the preindustrial δ13C (δ13CPI) distributions and find distinct δ13CPI signatures of the intermediate and upper halocline waters that reflect the difference in δ13CPI–PO4 relationship of Atlantic and Pacific source water.
A Framework for Understanding How Dynamics Shape Temperature Distributions
Authors: Linz Marianna , Chen Gang , Zhang Boer , Zhang Pengfei 
Published: February 2020

AbstractUnderstanding what physically sets the shape of temperature distributions will enable more robust predictions of local temperature with global warming. We derive the relationship between the temperature distribution shape and the advection of temperature conditionally averaged at each temperature percentile. This enables quantification of the shift of each percentile that is due to changes in the mean temperature, in horizontal temperature advection, and other processes (e.g., radiation and convection). We use this relationship to examine global model simulations in an idealized aquaplanet model with increasing carbon dioxide. Changes in the distribution with doubling and quadrupling of carbon dioxide are significant, and they are caused by different processes. We find that midlatitude temperature distributions can be explained mostly by the horizontal advection, except in the upper and lower 10% of the distribution.
Subduction Initiation During Collision‐Induced Subduction Transference: Numerical Modeling and Implications for the Tethyan Evolution
Authors: Zhong Xinyi , Li Zhong‐Hai 
Published: February 2020

AbstractThe collision‐induced subduction transference is a composite dynamic process including both the terrane collision/accretion and the subduction initiation (SI) at the neighboring passive margin. This process occurred repeatedly during the evolution of Tethyan systems, with multiple ribbon‐like continents or microcontinents drifting from Gondwana in the southern hemisphere and accreting to the Eurasian continent since Paleozoic. In the previous numerical studies, the dynamics of terrane collision and induced SI are investigated individually, which however need to be integrated to study the controlling factors and time scales of collision‐induced subduction transference. Systematic numerical models are conducted with variable properties of converging plates and different boundary conditions. The model results indicate that the forced convergence, rather than pure free subduction, is required to trigger and sustain the SI at the neighboring passive margin after terrane collision. In addition, a weak passive margin can significantly promote the occurrence of SI, by decreasing the required boundary force to reasonable value of plate tectonics. The lengths of subducted oceanic slab and accreting terrane play secondary roles in the occurrence of SI after collision. Under the favorable conditions of collision‐induced subduction transference, the time required for SI after collision is generally short within 10 Myr, which is consistent with the general geological records of Cimmerian collision and the following Neo‐Tethyan SI. In contrast, the stable Indian passive margin and absence of SI in the present Indian Ocean may be due to the low convergent force and/or the lack of proper weak zones, which remains an open question.
Pluto's Beating Heart Regulates the Atmospheric Circulation: Results From High‐Resolution and Multiyear Numerical Climate Simulations
Authors: Bertrand T. , Forget F. , White O. , Schmitt B. , Stern S. A. , Weaver H. A. , Young L. A. , Ennico K. , Olkin C. B. ,   the New Horizons Science Team
Published: February 2020

AbstractPluto's atmosphere is mainly nitrogen and is in solid‐gas equilibrium with the surface nitrogen ice. As a result, the global nitrogen ice distribution and the induced nitrogen condensation‐sublimation flows strongly control the atmospheric circulation. It is therefore essential for Global Climate Models to accurately account for the global nitrogen ice distribution in order to realistically simulate Pluto's atmosphere. Here we present a set of new numerical simulations of Pluto's atmosphere in 2015 performed with a Global Climate Model using a 50‐km horizontal resolution (3.75°
2.5°) and taking into account the latest topography and ice distribution data, as observed by the New Horizons spacecraft. In order to analyze the seasonal evolution of Pluto's atmosphere dynamics, we also performed simulations at coarser resolution (11.25°
7.5°) but covering three Pluto years. The model predicts a near‐surface western boundary current inside the Sputnik Planitia basin in 2015, which is consistent with the dark wind streaks observed in this region. We find that this atmospheric current could explain the differences in ice composition and color observed in the northwestern regions of Sputnik Planitia, by significantly impacting the nitrogen ice sublimation rate in these regions through processes possibly involving conductive heat flux from the atmosphere, transport of dark materials by the winds, and surface albedo positive feedbacks. In addition, we find that this current controls Pluto's general atmospheric circulation, which is dominated by a retrorotation, independently of the nitrogen ice distribution outside Sputnik Planitia. This exotic circulation regime could explain many of the geological features and longitudinal asymmetries in ice distribution observed all over Pluto's surface.
Ultralow-loss geometric phase and polarization shaping by ultrafast laser writing in silica glass
Authors: Sakakura Masaaki , Lei Yuhao , Wang Lei , Yu Yan-Hao , Kazansky Peter G. 
Published: February 2020

AbstractPolarization and geometric phase shaping via a space-variant anisotropy has attracted considerable interest for fabrication of flat optical elements and generation of vector beams with applications in various areas of science and technology. Among the methods for anisotropy patterning, imprinting of self-assembled nanograting structures in silica glass by femtosecond laser writing is promising for the fabrication of space-variant birefringent optics with high thermal and chemical durability and high optical damage threshold. However, a drawback is the optical loss due to the light scattering by nanograting structures, which has limited the application. Here, we report a new type of ultrafast laser-induced modification in silica glass, which consists of randomly distributed nanopores elongated in the direction perpendicular to the polarization, providing controllable birefringent structures with transmittance as high as 99% in the visible and near-infrared ranges and >90% in the UV range down to 330 nm. The observed anisotropic nanoporous silica structures are fundamentally different from the femtosecond laser-induced nanogratings and conventional nanoporous silica. A mechanism of nanocavitation via interstitial oxygen generation mediated by multiphoton and avanlanche defect ionization is proposed. We demonstrate ultralow-loss geometrical phase optical elements, including geometrical phase prism and lens, and a vector beam convertor in silica glass.
A new class of broadly neutralizing antibodies that target the glycan loop of Zika virus envelope protein
Authors: Qu Panke , Zhang Chao , Li Min , Ma Weimin , Xiong Pei , Liu Qingwei , Zou Gang , Lavillette Dimitri , Yin Feifei , Jin Xia , Huang Zhong 
Published: February 2020

AbstractZika virus (ZIKV) infection poses a serious threat to human health. However, no licensed vaccine or therapeutic drug is currently available for ZIKV. We have previously shown that recombinant ZIKV E80 protein induced potent neutralizing antibody response and protected mice from lethal viral challenge. In the present study, we isolated five ZIKV neutralizing monoclonal antibodies (mAbs) from E80-immunized mice. These five mAbs specifically bound and neutralized Asian-lineage ZIKV strains. Epitope mapping revealed that all of the five mAbs recognized a novel linear epitope located on the glycan loop of E protein domain I. Sequence alignment revealed that the epitope was extremely conserved in ZIKV but highly variable between ZIKV and other flaviviruses. Thus, these five mAbs form a new class of anti-ZIKV antibodies exhibiting broad-spectrum neutralization on Asian-lineage ZIKV. A representative of this mAb class, 5F8, was found to exert inhibitory function in vitro primarily at the early stage of the post-attachment viral entry process. Importantly, mAb 5F8 was able to confer full protection in a mouse model of ZIKV lethal infection. Our results have strong implications for developing anti-ZIKV vaccines and therapeutic mAbs.
Abundance and diversity of resistomes differ between healthy human oral cavities and gut
Authors: Carr Victoria R. , Witherden Elizabeth A. , Lee Sunjae , Shoaie Saeed , Mullany Peter , Proctor Gordon B. , Gomez-Cabrero David , Moyes David L. 
Published: February 2020

AbstractThe global threat of antimicrobial resistance has driven the use of high-throughput sequencing techniques to monitor the profile of resistance genes, known as the resistome, in microbial populations. The human oral cavity contains a poorly explored reservoir of these genes. Here we analyse and compare the resistome profiles of 788 oral cavities worldwide with paired stool metagenomes. We find country and body site-specific differences in the prevalence of antimicrobial resistance genes, classes and mechanisms in oral and stool samples. Within individuals, the highest abundances of antimicrobial resistance genes are found in the oral cavity, but the oral cavity contains a lower diversity of resistance genes compared to the gut. Additionally, co-occurrence analysis shows contrasting ARG-species associations between saliva and stool samples. Maintenance and persistence of antimicrobial resistance is likely to vary across different body sites. Thus, we highlight the importance of characterising the resistome across body sites to uncover the antimicrobial resistance potential in the human body.
Islet-1 synergizes with Gcn5 to promote MSC differentiation into cardiomyocytes
Authors: Xu Hao , Zhou Qin , Yi Qin , Tan Bin , Tian Jie , Chen Xueni , Wang Yue , Yu Xia , Zhu Jing 
Published: February 2020

AbstractMesenchymal stem cells (MSCs) specifically differentiate into cardiomyocytes as a potential way to reverse myocardial injury diseases, and uncovering this differentiation mechanism is immensely important. We have previously shown that histone acetylation/methylation and DNA methylation are involved in MSC differentiation into cardiomyocytes induced by islet-1. These modifications regulate cardiac-specific genes by interacting with each other in the promoter regions of these genes, but the molecular mechanism of these interactions remains unknown. In this study, we found that the key enzymes that regulate GATA4/Nkx2.5 expression are Gcn5/HDAC1, G9A, and DNMT-1. When α-methylene-γ-butyrolactone 3 (MB-3) was used to inhibit Gcn5 expression, we observed that the interactions among these key enzymes in the GATA4/Nkx2.5 promoters were blocked, and MSCs could not be induced into cardiomyocytes. Our results indicated that islet-1 could induce Gcn5 binding to GATA4/Nkx2.5 promoter regions and induce the interactions among Gcn5, HDAC1, G9A and DNMT-1, which upregulated GATA4/Nkx2.5 expression and promoted MSC differentiation into cardiomyocytes.
Perinatal outcomes of pregnancy in the fifth decade and beyond– a comparison of very advanced maternal age groups
Authors: Schwartz Anat , Many Ariel , Shapira Udi , Rosenberg Friedman Michal , Yogev Yariv , Avnon Tomer , Agrawal Swati , Shinar Shiri 
Published: February 2020

AbstractTo study the effect of very advanced maternal age on perinatal outcomes. A retrospective cohort study of women aged 45 years and above, who delivered ≥22 weeks of gestation in a single tertiary center between 1/ 2011 and 12/ 2018. Maternal and neonatal outcomes were compared between women ≥50 years and women of 45–49 years at delivery. Of 83,661 parturients, 593 (0.7%) were 45–49 years old and 64 (0.07%) were ≥50 years old. Obstetrical characteristics were comparable, though the rate of chronic hypertension and preeclampsia with severe features were greater in women ≥50 years (6.2% vs 1.4%, p = 0.04, 15.6% vs 7.0%, p = 0.01, 95% CI 0.19–0.86, respectively). Elective cesarean deliveries were independently associated with advanced maternal age ≥50 (OR 2.63 95% CI 1.21–5.69). Neonatal outcomes were comparable for singletons, but rates of ventilatory support and composite severe neonatal outcomes were higher in twin pregnancies of women ≥50 years (42.8% vs 13.5%, p = 0.01, and 21.4% vs 4.0%, p = 0.03, respectively). Healthy women ≥50 have higher elective cesarean rates, despite similar maternal and neonatal characteristics.
Changes in microbiome and metabolomic profiles of fecal samples stored with stabilizing solution at room temperature: a pilot study
Authors: Lim Mi Young , Hong Seungpyo , Kim Bo-Min , Ahn Yongju , Kim Hyun-Jin , Nam Young-Do 
Published: February 2020

AbstractThe gut microbiome is related to various host health conditions through metabolites produced by microbiota. Investigating their relationships involves association analysis of the population-level microbiome and metabolome data, which requires the appropriate collection, handling, and storage of specimens. Simplification of the specimen handling processes will facilitate such investigations. As a pilot study for population-level studies, we collected the fecal samples from three volunteers and tested whether a single sample collection procedure, particularly using OMNIgene-GUT, can be used to reliably obtain both microbiome and metabolome data. We collected fecal samples from three young and healthy Korean adults, stored them at room temperature with and without OMNIgene-GUT solution up to three weeks, and analyzed their microbiome and metabolite profiles. We found that the microbiome profiles were stably maintained in OMNIgene-GUT solution for 21 days, and the abundance relationships among metabolites were well preserved, although their absolute abundances slightly varied over time. Our results show that a single sampling procedure suffices to obtain a fecal sample for collecting gut microbiome and gut metabolome data of an individual. We expect that the health effects of gut microbiome via fecal metabolites can be further understood by increasing the sampling size to the population level.
Influencing factors and application prospects of CO2 flooding in heterogeneous glutenite reservoirs
Authors: Wang Jinkai , Zhang Yuanpei , Xie Jun 
Published: February 2020

AbstractIn recent years, large amounts of CO2 emissions have led to many environmental problems. Developing a reasonable approach to carbon dioxide emissions is one of the most important issues for the sustainable development of human civilization. Compared with CO2 geological storage, CO2 flooding has greater advantages and a higher utilization efficiency. CO2 flooding technology has been successfully applied to many types of reservoirs, such as conventional sandstone reservoirs, low-permeability reservoirs, and carbonates. In this paper, the feasibility of CO2 flooding in glutenite reservoirs is studied. First, the glutenite reservoir is divided into fine stages, and reasonable vertical development units are determined. On this basis, the distribution scale, genetic environment and formation mode of the glutenite reservoir are characterized in detail and their spatial distribution rules are depicted in three dimensions. Then, the influencing factors of CO2 flooding in the glutenite reservoir are analysed via reservoir numerical simulation technology. The effects of reservoir thickness, reservoir heterogeneity, macropores, dominant channels and fracturing on CO2 flooding efficiency are evaluated individually, and a set of reasonable parameters constituting an evaluation system for CO2 flooding in the glutenite reservoir is established. Finally, based on parameter optimization, the disadvantaged conditions of CO2 flooding in glutenite reservoirs are optimized, and their effects are gradually eliminated. In view of the characteristics of glutenite reservoirs, a unique three-dimensional well pattern arrangement is designed, different injection modes are optimized, and suitable injection agents are tested. These methods are conducive to improving the effect of reservoir parameters on CO2 flooding efficiency, allowing these reservoirs to be used for CO2 flooding. Based on these new methods, the displacement effect of the Yanjia-Yongan glutenite reservoir is predicted. Our results show that the reservoir has been developed efficiently and achieved a high recovery rate, the displacement front of the CO2 has become more uniform, and the sweep range has become wider. After extending the successful application of CO2 flooding in this reservoir to all of the glutenite reservoirs in the entirety of the Bohaiwan Basin, we predict that the oil recovery rate may reach 40%, with a cumulative oil recovery rate of approximately 3.04 × 108 t and a total CO2 consumption of 1.672 × 108 t. Thus, the proposed approach not only can improve the atmospheric environment but can also greatly improve the efficiency of oil displacement.