bluuebunny/crossref_metadata_2025_split huggingface dataset:
SINDROME EXTRAPIRAMIDAL Y ACATISIA SEGUN EL TIPO DE NEUROLEPTICO UTILIZADO
Authors:   SERVICIO DE PSIQUIATRIA,COMPLEJO HOSPITALARIO DE SORIA, Soria, Martínez Gallardo Ricardo 
Published: November 2020

Introducción:	El término discinesia se usa habitualmente de manera general para describir movimientos anormales propios del tratamiento neuroléptico sin diferenciar en absoluto a que tipo de tratamiento se refiere.	En esta primera fase del estudio se intenta comprobar la sintomatología discinética que presentan los cuatro grupos de tratamientos: 	oral típico, 	oral atípico, 	depot típico 	larga duración atípico	y las diferencias existentes entre ellos. Metodología:	Se han seleccionado 41 pacientes en cuatro grupos con mas de tres años de tratamiento neuroléptico: 	9 pacientes con tratamiento oral típico 	10 pacientes con tratamiento típico depot 	12 pacientes con tratamiento oral atípico 	10 pacientes con tratamiento depot atípico A todos ellos se le han pasado las escalas: 	AIMS (movimientos involuntarios) 	BARS (de acatisia) Analisis de los Resultados: 	Los pacientes con tratamiento depot típico son aquellos que presentan puntuaciones significativamente mayores en la escala AIMS,que el resto. 	Los pacientes con tratamiento consta atípico presentan puntuaciones significativamente mayores en la AIMS que los orales típicos y atípicos. 	En la escala de acatisia hay diferencias significativas entre atípicos y típicos Conclusiones: 	Los pacientes con tratamiento típico depot son los que mas sintomatología discinética presentan independientemente del sexo y la edad. 	Los pacientes con tratamiento depot atípico presentan mayor incidencia discinética que los pacientes con tratamiento oral tanto típico como atípico, sobre todo mas significativo en mujeres. 	Los pacientes con tratamiento típico oral no presentan diferencias significativas con los de tratamiento atípico oral. 	En cuanto a la acatisia es mayor estadisticamente significativa en el grupo de depot atípico y de oral atípico.
Palmitato de paliperidona formulación trimestral en pacientes esquizofrénicos con trastorno de uso de cannabis. Estudio en espejo de 24 meses de seguimiento
Authors:   U.G.C. Salud Mental Área Hospitalaria Virgen Macarena, Sevilla, Romero Guillena Samuel Leopoldo , Garcia de Diego Beatriz Oda Plasencia ,   U.G.C. Salud Mental Área Hospitalaria Virgen del Rocio, Sevilla, Cantalejo Conde José Antonio ,   U.G.C. Salud Mental Área Hospitalaria Virgen Macarena, Sevilla
Published: November 2020

Objetivo: Evaluar la eficacia y tolerabilidad de la formulación trimestral de palmitato de paliperidona (PP 3m) en pacientes esquizofrénicos en comorbilidad con trastornos de uso de cannabis, que estaban en tratamiento previo durante al menos 24 meses con la formulación mensual de palmitato de paliperidona (PP 1m) Material y método: Estudio de imagen en espejo: 24 meses antes y después del cambio de tratamiento a la formulación trimestral de palmitato de paliperidona y con una periodicidad trimestral se pasaron las siguientes escalas: -	Escala de Síndrome Positivo y Negativo de la esquizofrenia (PANSS), Escala del funcionamiento Personal y Social (PSP), Escala de Efectos Secundarios UKU y Cuestionario sobre la satisfacción del paciente hacia la medicación (PSQM) Criterios de inclusión:1) Edades entre los 18 y 65 años con diagnóstico de esquizofrenia y consumo de cannabis (criterios DSM 5); 2) Pacientes clínicamente estabilizados con la formulación mensual de palmitato de paliperidona durante al menos los últimos 4 meses previos al cambio a la formulación trimestral; 3) Pacientes que llevaran en tratamiento con la formulación de mensual de palmitato de paliperidona al menos 24 meses. La población estudiada se compone de 8 pacientes. Resultados y conclusiones A los 24 meses: No existen cambios significativos en la puntuación total de la escala PANSS (manteniendo puntuaciones totales menores a 70) ni en la puntuación de la escala PSP (manteniéndose puntuaciones superiores a 60 puntos). Incremento en el porcentajes de paciente que refieren estar “extremadamente satisfechos con su medicación (PSQM) (87,5% con PP3M vs 50% con PP1M) Sin cambios en el perfil de tolerabilidad respecto a la formulación mensual de palmitato de paliperidona. Conclusiones: A los 24 meses, los pacientes que cambiaron la formulación trimestral de palmitato de paliperidona, mantuvieron la estabilidad psicopatológica y funcional lograda previamente con la formulación mensual de palmitato de paliperidona.
Chemical composition and microbiological quality of bee pollen
Authors: Lorini Alexandre , Rosa Claudineli Cassia Bueno da , Oliveira Livia Teixeira , Wobeto Carmen 
Published: November 2020

Besides honey and propolis, bee products already well consolidated, pollen also has relevant economic, nutritional and functional value. As the quality of the final product is directly related to the region where it is collected and processed, this work has evaluated the nutritional and microbiological quality of two dehydrated bee pollens from São Paulo state and the other produced by beekeepers from northern of Mato Grosso state, but with no inspection. Physical-chemical and microbiological quality, phenolic composition and mineral profile analysis were performed. It was observed that both pollens presented satisfactory quality regarding protein contents (24.8 ± 2.4 g 100 g-1), total sugars (36.2 ± 1.1 g 100 g-1), lipids (4.0 ± 0.3 g 100 g-1), ashes (2.6 ± 0.05 g 100 g-1), free acidity (238.7 ± 4.5 mEq Kg-1) and pH (4.8 ± 0.03), however regarding the humidity levels (6.6 ± 2.2 g 100 g-1) both samples were not in accordance with recommended by law (4 g 100 g-1). The bioactive profile has shown a significant amount of phenolic compounds (37.3 ± 1.1 mg GAE g-1) and flavonoids (41.8 ± 2.5 mg QE g-1), besides potential antioxidants around, approximately, 50 and 80%. Microbiological analyzes have revealed low bacterial contamination (≤ 3.6 MPN g-1), molds and yeasts (variation between 1.2x103 and 4x101 CFU g-1), according to values stipulated by the current legislation, being observed the absence of Salmonella sp. and Escherichia coli. The bee pollens investigated have nutritional quality and safety for consumption. However, pollen from São Paulo state showed greater antioxidant potential, probably due to its higher content of phenolics when compared with pollen from Mato Grosso state.
Cotton response to nitrogen fertilization in the integrated crop-livestock system
Authors: Steiner Fábio , Zuffo Alan Mario , Silva Kátia Cristina , Machado de Oliveira Lima Isabela , Ardon Hector José Valerio 
Published: November 2020

Cotton has been widely cultivated in the Cerrado region, including the crop-livestock integration system under no-till. The objective of this study was to evaluate the effects of plant residues from ruzigrass [Urochloa ruziziensis (R. Germ. C.M. Evrard) Crins] and nitrogen fertilization on nitrogen use efficiency, growth, and yield of cotton crop (Gossypium hirsutum L. R. latifolium Hutch.), cv. TMG 44 B2RF. The experimental design was randomized blocks, in a split plot scheme, with four replications. The plots consisted of three production systems: i) conventional cotton cropping in fallow area; ii) cotton cropping in the presence of straw from the shoots and roots of ruzigrass plants; iii) cotton cropping only in the presence of residues from the ruzigrass roots. The subplots consisted of five rates of N (0, 40, 80, 120 and 160 kg ha–1), applied at 30 and 50 days after seedling emergence. The presence of ruzigrass straw provided less growth and development of cotton, in addition to less N uptake by plants. The cotton cropping in the crop-livestock integration system in the presence of residues from the roots and shoots of the ruzigrass plants resulted in the greater cotton yield in the second year, demonstrating the importance of the straw formation of the cover crops for the sandy soils of the Cerrado region. The optimal application rate of N in topdressing for the cropping of cotton in succession or not with ruzigrass residues in sandy soil varies from 100 to 110 kg N ha–1.
THE POSSIBILITY OF PREDICTION OF DENTAL CARIES IN CHILDREN DURING THE PERIOD OF CHANGEBITE
Authors: Mityaeva Tatyana , Skripkina Galina , Ekimov Evgeniy , Matskieva Olga 
Published: November 2020

Background. Preventive measures that are implemented through the introduction of regional prevention programs have a massive focus and do not lead to a decrease in dental morbidity, because they are based on routine preventive measures without taking into account the individual characteristics of metabolic processes in the patient's oral cavity. All this confirms the need to abandon the mass approach when carrying out preventive measures, and requires the search for modern methods for predicting dental caries, based on predictive diagnostics of the risk of caries, which should be a key element of clinical examination of the pediatric population by a dentist.
Purpose of the study: on the basis of a comprehensive clinical and laboratory approach with the use of mathematical analysis of the obtained data on homeostasis of the oral cavity, to establish predictors of the development of the carious process in children in order to determine the possibility of predicting dental caries during the period of mixed bite.
Methodology. To achieve this goal, a comprehensive clinical and laboratory examination of metabolic processes in the oral cavity was carried out in 60 caries-resistant children during the period of mixed bite: from 7 to 12 years. Statistical analysis was performed using the STATISTICA 8.0 software.
Results. According to the results of the study, strong relationships were revealed between individual clinical and laboratory indicators-predictors, an optimal set of predictors was established for constructing classification models for patients with different types of MCS, which is a prerequisite for the possibility of predicting the risk of caries development in children during the mixed bite period.
Conclusions. An optimal set of predictors has been established for constructing classification models for patients with different types of ISS for creating computer programs aimed at preclinical diagnostics of the subclinical course of the carious process with access to prediction, which will allow planning individual primary preventive measures in children during the period of active formation of hard dental tissues.
PREVENTION OF TOXIC-ALLERGIC REACTIONS WHEN USING DENTURES AND DEVICES
Authors: Zotov Aleksey , Podoprigora Anna , Komarova Yuliya , Kalivradzhiyan Edvard , Stepanov Ilya , Belenova Irina 
Published: November 2020

Subject. Today, nanoparticles of chemical elements that make up the body are of particular interest. Such nanomaterials usually do not cause allergic reactions, they can potentially be broken down and removed from it, and, for example, drugs can be placed in the pores of these materials. At the Department of Prosthetic Dentistry of V.G. N.N. Burdenko together with Voronezh State University developed a polymer modified with nanosized silver particles, which was successfully tested on patients in the manufacture of removable plate prostheses. However, there is no data on the effect of this polymer in patients with complex jaw pathology in combination with somatic pathology, in which visible changes occur in the oral cavity.
Goal ― to consider the problem of prevention of toxic-allergic reactions when using complex-jaw prostheses and devices. To study the state of the oral microbiocenosis and the cytological characteristics of the mucous membrane in patients with apparatus bases made of a polymer modified with nanoscale silver. Materials and methods. 80 people were examined and 60 patients were treated for complete absence of teeth with various degrees of atrophy according to A.I.Doynikov (1967) I, II, III, IV, V, with a uniform quantitative distribution in groups.
Methodology. 80 people were examined and 60 patients were treated for complete absence of teeth with various degrees of atrophy according to A.I.Doynikov (1967) I, II, III, IV, V, with a uniform quantitative distribution in groups.
Results. The dynamics of the inflammatory processes of the mucous membrane of the prosthetic bed under the bases of removable jaw devices made by the known method and with bases from modified materials was studied. A complex of personalized prevention of complications associated with the action of basic polymers has been developed.
Conclusion. Obtained by analyzing the results of the study, it was possible to create, on the basis of the use of modified acrylic polymer as the material of the bases of removable prostheses and devices, a program for individual prevention of the inflammatory complications induced by them from the mucosa of the prosthetic bed, the efficiency level of which is at least 60 %. This predisposes to recommendations for the further implementation of the modified nanosilver acrylic polymer in practical dentistry.
THE RELATIONSHIP OF QUALITY OF LIFE INDICATORS AND PSYCHOLOGICAL STATUS FEATURES IN CADETS OF THE UFA LAW INSTITUTE OF THE MINISTRY OF INTERNAL AFFAIRS OF THE RUSSIAN FEDERATION WITH CHRONIC GENERALIZED CATARRHAL GINGIVITIS
Authors: Sitdikova Olesya , Kabirova Milyausha , Gubina Oksana 
Published: November 2020

Subject. Chronic generalized catarrhal gingivitis affects the physical condition of a person, as well as the psychology of their behavior, emotional reactions, as well as their role in social life. Doctors are not always set up to assess the quality of life and patient satisfaction with the therapy. The peculiarity of this disease is the vastness of its clinical manifestations, and the need to start treatment in a timely manner, and patients taking medications themselves, affects poor adherence to treatment. These characteristics have an impact on the quality of life, and if the quality of life improves as a result of therapy, this motivates patients to effectively control their condition.
Goal ― to assess the quality of life, frequency and severity of anxiety and depressive disorders in cadets with chronic generalized catarrhal gingivitis.
Methodology. We conducted a survey of 140 cadets aged 18 to 25 years.
Results.The revealed patterns suggest that bleeding, gum pain,and halitosis often contribute to the clinical manifestation of anxiety and depressive disorders in cadets with chronic generalized catarrhal gingivitis, thereby impairing the quality of life. The combination of various metabolic factors in a closed circle mutually increases the severity of not only clinical manifestations of chronic generalized catarrhal gingivitis, but also affects the mental status of the patient, increasing the degree of neurosis-like manifestations
Conclusion. Chronic generalized catarrhal gingivitis significantly affects the decline in indicators of not only physical health, but also mental well-being. High levels of anxiety and depression are most significantly correlated with indicators of mental and physical health of cadets . Thus, anxiety and depression of a somatogenic nature has a negative impact on the quality of life, aggravates the course of the underlying disease, significantly affecting the General well-being of the patient.
INFLUENCE OF MEDICATION ON FLARE UP AND INFECTION AFTER ELECTIVE ORTHOPEDIC SURGERY IN RHEUMATOID ARTHRITIS PATIENT - A NARRATIVE REVIEW
Authors: Rosadi Yaldi , Marinta Yustin , Afifah Muthiah Nur 
Published: November 2020

Background: Orthopedic Surgery in Rheumatoid Arthritis (RA) patients is still controversial between orthopedic surgeons and rheumatologists, mainly due to infection and disease flares. The incidence of postoperative infections may be high due to the immunosuppressive effect of RA medication. Conversely, discontinuance of antirheumatic agents increases the possibility of a disease flare. The objective of our review is to assess the influence of drugs on both incidences.Literature Review: There were 13 studies included in this review. Methotrexate (MTX) is the most common csDMARD option among the included studies. One retrospective study that the incidence of flares tends to be higher among the group of patients who received MTX therapy and stopped more than one week before surgery than the group who did not stop. The use of MTX doses of 5 to 10 mg/week did not show an association with infection or flare incidence. On the use of bDMARD, 37.0% of patients had higher surgical site infection (SSI). Specifically, Tumor Necrosis Factor-alpha (TNF-α) inhibitors significantly (OR: 9.5, 95% CI: 1.0-88.8) increase the incidence of postoperative infections in standard-dose and high-dose, but not significantly in the rate of flares.Summary: csDMARD is recommended for continuous therapy, whereas for bDMARD, although it is recommended for withholding in the perioperative period, the results of the study did not show significant differences. The ideal dosage of medication is by the basic properties of the drug. In comparison, the incidence of flares and infections was significantly higher in biologic than csDMARD.
Associations of Blood Pressure and Heart Rate and Their Contribution to the Development of Cardiovascular Complications and All-Cause Mortality in the Russian Population of 25-64 Years
Authors: Shalnova S. A. , Kutsenko V. A. , Kapustina A. V. , Yarovaya E. B. , Balanova Yu. A. , Evstifeeva S. E. , Imaeva A. E. , Maksimov S. A. , Muromtseva G. A. , Kulakova N. V. , Kalachikova O. N. , Chernykh T. M. , Belova O. A. , Artamonova G. V. , Indukaeva E. V. , Grinshtein Yu. I. , Libis R. A. , Duplyakov D. V. , Rotar O. P. , Trubacheva I. A. , Serebryakova V. N. , Efanov A. Yu. , Konradi A. O. , Boytsov S. A. , Drapkina O. M. 
Published: November 2020

Aim. To study the relationship of blood pressure (BP) and heart rate (HR) in a sample of men and women 25-64 years old and their predictive value for the development of fatal and non-fatal cardiovascular diseases (CVD) and mortality from all causes.Material and methods. Prospective observation was for cohorts of the population aged 25-64 years from 11 regions of the Russian Federation. 18,251 people were included in the analysis. Each participant gave written informed consent. All surveyed persons were interviewed with a standard questionnaire. BP was measured on the right hand with an automatic tonometer. BP and HR were measured twice with an interval of 2-3 min with the calculation of the average value. The patients were divided into 4 groups: the first group with BP<140/90 ><140/90 mm Hg and HR≤80 beats/min; the second group – BP<140/><140/90 mm Hg and HR>80; the third group – BP≥140/90 mm Hg and HR≤80; the fourth group – BP≥140/90 mm Hg and HR>80 beats/min. Risk factors and cardiovascular history were analyzed as well. Deaths over 6 years of follow-up occurred in 393 people (141 – from CVD). Statistical analysis was performed using the open source R3.6.1 system.Results. A HR>80 beats/min was found in 26.3% of people with BP≥140/90 mm Hg, regardless of medication. Analysis of the associations between HR and BP showed that for every increase in HR by 10 beats/min, systolic BP increases by 3 mm Hg. (p<0.0001). The group with HR>80 beats/min and BP≥140/90 mm Hg had the shortest life expectancy (p<0.001). Adding an increased HR to BP≥140/90 mm Hg significantly><0.001). Adding an increased HR to BP≥140/90 mm Hg significantly worsened the prognosis of patients. Similar results were obtained in the analysis of cardiovascular survival. Elevated BP and elevated HR had the same effect on outcomes, except for the combined endpoint, where the contribution of elevated BP was predominant. However, their combined effect was the largest and highly significant for the development of the studied outcomes, even after adjusting for other predictors. With an increase in HR by every 10 beats/min, the risk of mortality increased statistically significantly by 22%.Conclusion. The prevalence of HR>80 beats/min in people with BP≥140 mm Hg amounted to 26.34%. Every 10 beats/min significantly increases the risk of mortality by 22%. Increased HR with elevated BP leads to increased adverse outcomes.
The Study of the Impact Factors of Behaviors of Nursing Intern Students:&nbsp;PRECEDE-Based Structural Equation Modeling Analysis
Authors: Zhang Li , Luo Yetao , Chen Yanhan 
Published: November 2020

Abstract
Background: Tobacco hazard is known as one of the most critical public health problems. Nurses could and should help patients to quit smoking. However, the lack of tobacco cessation education of nurses at medical school leads to the absence of behaviors helping smokers to quit. The analysis of the factors that influencing the nursing interns to help smokers to quit provide evidence for nursing school to administer tobacco cessation education to facilitate more behaviors of smoking cessation in future nurses.Method: To explore the interaction and the effect coefficient among the influencing factors of the 5As behaviors of nursing interns in helping smokers to quit provide and to provide evidences for the tobacco cessation education, a questionnaire based on the PRECEDE theory was developed with consideration of predisposing factor, enabling factor and reinforcing factor. Random Cluster Sampling was used to conduct a survey in 13 teaching hospitals selected from 29 in Chongqing to assess the 5As behaviors of all nursing interns. A structural equation model was established to test the path and effect coefficient of their 5As behaviors.Results: The survey investigated 1358 nurses, and the model fitted well with the data. The tobacco cessation education, one of the enabling factors, imposed max effect on the 5As of nursing interns directly（β=0.542，p<0.001） and indirectly（β=0.38，p<0.001）through self-efficacy. The reinforcing factors ( smoking cessation environment) imposed direct effect (β=0.305，p<0.001）and indirect effect on the 5As of nursing interns through attitude changes. Predisposing factors including self-efficacy influenced the 5As directly, while attitude（β=0.001，p<0.05）and knowledge（β=0.008，p<0.05）of tobacco cessation implied indirect influence on the 5As through self-efficacy change. Conclusion: Tobacco cessation education was the major factor that influenced the nursing interns’ behaviors of helping patients to quit smoking. Enhanced responsibility of smoking cessation education and skills training of clinical teachers can prompt them to actively help patients to quit smoking, actively instruct students the knowledge and skills of smoking quit to increase students' behavior of helping smokers to quit.