bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, controlled trial
Authors: Bueno-Hernández Nallely , Esquivel-Velázquez Marcela , Alcántara-Suárez Raúl , Gómez-Arauz Angélica Y. , Espinosa-Flores Aranza J. , de León-Barrera Karen L. , Mendoza-Martínez Viridiana M. , Sánchez Medina Gabriela A. , León-Hernández Mireya , Ruiz-Barranco Alejandra , Escobedo Galileo , Meléndez Guillermo 
Published: April 2020

Abstract
Background
Non-nutritive sweeteners (NNS) are widely consumed by humans due to their apparent innocuity, especially sucralose. However, several studies link sucralose consumption to weight gain and metabolic derangements, although data are still contradictory.

Objective
To determine the effect of acute and chronic consumption of sucralose on insulin and glucose profiles in young healthy adults.

Material and methods
This was a randomized, parallel, double-blind, placebo-controlled trial conducted in healthy young adults from 18 to 35 years old, without insulin resistance. A hundred thirty seven participants were randomized into three groups: a) volunteers receiving 48 mg sucralose, b) volunteers receiving 96 mg sucralose, and c) controls receiving water as placebo. All participants underwent a 3-h oral glucose tolerance test (OGTT) preceded by consuming sucralose or placebo 15 min before glucose load, at two time points: week zero (Wk0) and week ten (Wk10). Serum insulin and glucose were measured every 15 min during both OGTTs.

Results
Compared to Wk0, consumption of sucralose for 10 weeks provoked 1) increased insulin concentrations at 0 min (7.5 ± 3.4 vs 8.8 ± 4.1 μIU/mL; p = 0.01), 30 min (91.3 ± 56.2 vs 110.1 ± 49.4 μIU/mL; p = 0.05), 105 min (47.7 ± 24.4 vs 64.3 ± 48.2 μIU/mL; p = 0.04) and 120 min (44.8 ± 22.1 vs 63.1 ± 47.8 μIU/mL; p = 0.01) in the 48 mg sucralose group; 2) increased blood glucose at − 15 min (87.9 ± 4.6 vs 91.4 ± 5.4 mg/dL; p = 0.003), 0 min (88.7 ± 4 vs 91.3 ± 6 mg/dL; p = 0.04) and 120 min (95.2 ± 23.7 vs 106.9 ± 19.5 mg/dL; p = 0.009) in the 48 mg sucralose group; 3) increased area under the curve (AUC) of insulin in both 48 and 96 mg sucralose groups (9262 vs 11,398; p = 0.02 and 6962 vs 8394; p = 0.12, respectively); and 4) reduced Matsuda index in the 48 mg sucralose group (6.04 ± 3.19 vs 4.86 ± 2.13; p = 0.01).

Conclusions
These data show that chronic consumption of sucralose can affect insulin and glucose responses in non-insulin resistant healthy young adults with normal body mass index (between 18.5 and 24.9 kg/m2), however, the effects are not consistent with dose; further research is required.

Clinical trial registry
NCT03703141.
Lipidomic profile and candidate biomarkers in septic patients
Authors: Mecatti Giovana Colozza , Messias Márcia Cristina Fernandes , de Oliveira Carvalho Patrícia 
Published: April 2020

AbstractSepsis is a severe disease with a high mortality rate. Identification and treatment in the initial hours of the disease improve outcomes. Some biomarkers like procalcitonin and C-reactive protein are used for diagnosis and to access sepsis prognosis and they can help in clinical decision-making, but none has sufficient specificity or sensitivity to be routinely employed in clinical practice. This review seeks to evaluate lipid metabolism alterations in patients with sepsis and the possibility of using the respective metabolites as biomarkers of the disease. A search of the main electronic biomedical databases was conducted for the 20-year period ending in February 2020, focused on primary research articles on biomarkers in sepsis. The keywords included sepsis, septic shock, biomarker, metabolomic, lipidomic and lysophosphatidylcoline.. It concludes that altered lipid profiles, along with the progress of the disease should provide new insights, enabling a better understanding of the pathogenic mechanisms and making it possible to design new early diagnosis and therapeutic procedures for sepsis.
Association between rs2107595 HDAC9 gene polymorphism and advanced carotid atherosclerosis in the Slovenian cohort
Authors: Grbić Emin , Gorkič Nataša , Pleskovič Aleš , Zorc Marjeta , Ljuca Farid , Gasparini Mladen , Mrđa Božidar , Cilenšek Ines , Mankoč Sara , Banach Maciej , Petrovič Daniel , Fras Zlatko 
Published: April 2020

Abstract
Background
Histone deacetylase 9 (HDAC9) plays an important role in transcriptional regulation, cell cycle progression and developmental events; moreover, it has been investigated as a candidate gene in a number of conditions, including the onset and progression of atherosclerosis. We hypothesized that the rs2107595 HDAC9 gene polymorphism may be associated with advanced carotid artery disease in a Slovenian cohort. We also investigated the effect of this polymorphism on HDAC9 receptor expression in the internal carotid artery (ICA) specimens obtained by endarterectomy.

Methods
This case-control study enrolled 619 unrelated Slovenian patients: 311 patients with ICA stenosis > 75% as the study group and 308 patients with ICA stenosis < 50% as the control group. Patient laboratory and clinical data were obtained from the medical records. The rs2107595 polymorphisms were genotyped using TaqMan SNP Genotyping assay. HDAC9 expression was assessed by immunohistochemistry in 30 ICA specimens from patients with ICA atherosclerosis > 75%, and the numerical areal density of HDAC9 positive cells was calculated.

Results
The occurrence of advanced ICA atherosclerosis in the Slovenian cohort was 3.81 times higher in the codominant genetic model (OR = 3.81, 95%CI = 1.06–13.77, p = 0.04), and 3.10 times higher in the recessive genetic model (OR = 3.10, 95%CI = 1.16–8.27, p = 0.02). In addition, the A allele of rs2107595 was associated with increased HDAC9 expression in the ICA specimens obtained by endarterectomy.

Conclusions
We observed a significant association between the AA genotype of rs2107595 with the advanced carotid artery disease in our Slovenian cohort, indicating that this polymorphism may be a genetic risk factor for ICA atherosclerosis.
Vitamin D receptor (VDR) gene FokI, BsmI, ApaI, and TaqI polymorphisms and osteoporosis risk: a meta-analysis
Authors: Yadav Upendra , Kumar Pradeep , Rai Vandana 
Published: April 2020

AbstractBackgroundOsteoporosis is a disease of the bones in which the density of the bones decreases. The prevalence of this disease greatly varies in different populations of the world. Numerous studies have been investigated VDR gene polymorphisms as osteoporosis risk in different ethnic groups. In present meta-analysis, the aim is to find out the role of VDR gene polymorphisms (FokI,BsmI,ApaI, andTaqI) in osteoporosis risk.MethodsSuitable case-control studies for present meta-analysis were retrieved from four electronic databases. Open Meta-Analyst program was used for statistical analyses.ResultsStudies investigatedBsmI (65 studies; 6880 cases/8049 controls),ApaI (31 studies; 3763 cases/3934 controls),FokI (18 studies; 1895 cases/1722 controls), andTaqI (26 studies; 2458 cases/2895 controls) polymorphisms that were included in the present meta-analysis. A significant association was found between the dominant model ofFokI (ORff + Ffvs.FF= 1.19, 95% CI = 1.04–1.36,p= 0.01,I2= 39.36%) in the overall analysis and recessive model of the Caucasian population ofTaqI polymorphism (ORTT + Ttvs.tt= 1.35, 95% CI = 1.11–1.63,p= 0.002,I2= 50.07%) with osteoporosis. On the other hand, no such effect is found in any other genetic models and in any other gene polymorphisms of the overall analyses or sub-group analyses.ConclusionIn conclusion, the authors found that the dominant model ofFokI in the overall analysis and recessive model ofTaqI in the Caucasian population are significantly associated with the development of osteoporosis.
Understanding generation and regeneration of pancreatic β cells from a single-cell perspective
Authors: Yu Xin-Xin , Xu Cheng-Ran 
Published: April 2020

ABSTRACT
Understanding the mechanisms that underlie the generation and regeneration of β cells is crucial for developing treatments for diabetes. However, traditional research methods, which are based on populations of cells, have limitations for defining the precise processes of β-cell differentiation and trans-differentiation, and the associated regulatory mechanisms. The recent development of single-cell technologies has enabled re-examination of these processes at a single-cell resolution to uncover intermediate cell states, cellular heterogeneity and molecular trajectories of cell fate specification. Here, we review recent advances in understanding β-cell generation and regeneration, in vivo and in vitro, from single-cell technologies, which could provide insights for optimization of diabetes therapy strategies.
MMP14 is required for delamination of chick neural crest cells independently of its catalytic activity
Authors: Andrieu Cyril , Montigny Audrey , Bibonne Anne , Despin-Guitard Evangeline , Alfandari Dominique , Théveneau Eric 
Published: April 2020

ABSTRACT
Matrix metalloproteinases have a broad spectrum of substrates ranging from extracellular matrix components and adhesion molecules to chemokines and growth factors. Despite being mostly secreted, MMPs have been detected in the cytosol, the mitochondria or the nucleus. Although most of the attention is focused on their role in matrix remodeling, the diversity of their substrates and their complex trafficking open the possibility for non-canonical functions. Yet in vivo examples and experimental demonstration of the physiological relevance of such activities are rare. Here, we have used chick neural crest (NC) cells, a highly migratory stem cell population likened to invasive cancer cells, as a model for physiological epithelial-mesenchymal transition (EMT). We demonstrate that MMP14 is required for NC delamination. Interestingly, this role is independent of its cytoplasmic tail and of its catalytic activity. Our in vivo data indicate that, in addition to being a late pro-invasive factor, MMP14 is also likely to be an early player, owing to its role in EMT.
Isolated and simultaneous perceived barriers to physical activity counseling
Authors: Souza Neto João Miguel de , Guerra Paulo Henrique , Rufino Emily Alves , Costa Filipe Ferreira da 
Published: April 2020

The aim of this study was to determine the prevalence of perceived barriers and their isolated and simultaneous association with the practice of counseling for physical activity by primary health care workers. This is a cross-sectional study with 591 health workers, who work in the Family Health Teams. Counseling for physical activity was defined as the accomplishment of such a practice for more than six months. The barriers investigated were lack of time, lack of knowledge, lack of professionals to guide, lack of available instructional material, lack of environmental resources and lack of financial resources of the user. Binary logistic regression was used to evaluate the possible relationships between perceived barriers and the practice of counseling for physical activity. Non-counselors reported a lack of time (68.8%), knowledge (68.5%) and orientation (63.2%) compared to their peer counselors (p ≤ 0.001). Professionals with three or more barriers were more likely not to advise (OR = 3.91; 95%CI: 2.10 - 7.29) when compared to those who reported no concurrent barriers. These results indicate that the simultaneity of perceived barriers is negatively associated to the practice of counseling for physical activity of health workers.
Prevención de Trastornos Musculoesqueléticos mediante la mejora de Hábitos Posturales: experiencia en el colectivo de limpieza
Authors: Puig Aventin Vanessa , Gallego Fernández Yolanda , Moreno Moreno María Pilar 
Published: April 2020

Objetivo: El objetivo es valorar la efectividad de una intervención de mejora de hábitos posturales para prevenir los trastornos musculoesqueléticos en el sector limpieza.
Método: Se diseñó una intervención específica para el colectivo de limpieza, mediante una serie de acciones continuadas en el tiempo dirigidas a fomentar una buena higiene postural y el ejercicio físico. Se aplicó la intervención en dos años distintos (estudio original y estudio de replicación), a una muestra de trabajadores del subsector Limpieza general de edificios, pertenecientes a distintos centros de trabajo de una misma empresa. Se incorporaron herramientas de valoración de las intervenciones basadas en la autopercepción y el registro de los hábitos por un observador externo.
Resultados: En el primer estudio se obtuvo un aumento del 92% de las personas que manifestaban adoptar siempre o casi siempre buenos hábitos posturales durante las tareas de limpieza. En el estudio de replicación esta mejora fue del 67%. Las principales mejoras se observaron en: flexionar las piernas, mantener la espalda recta, alternancia de brazos y buscar puntos de apoyo. En la valoración observacional de los hábitos posturales se constató la mejoría autopercibida.
Conclusiones: El modelo de intervención fundamentado en una serie de acciones continuadas en el tiempo, favoreciendo el empoderamiento de los trabajadores puede ser efectivo para mejorar, a corto plazo, los hábitos posturales del colectivo de limpieza. Se precisa de más estudios para valorar si el cambio de hábitos se mantiene a largo plazo y su efecto sobre la disminución de los trastornos musculoesqueléticos.
Evolución temporal de la incidencia por incapacidad temporal de origen común según tramos de duración (2009-2018)
Authors: Ballesteros Polo Mónica , Sampere Valero Maite , López López Juan Carlos , Sacristán Nieto Rosa , Ruiz Julián Ana , Alguacil García Sara , Santos Ávila Elisabeth , García Rubia Silvia , López Costa Bibiana , Martínez Martínez José Miguel 
Published: April 2020

Objetivo: Describir la evolución temporal (2009-2018) de la incidencia de la incapacidad temporal por contingencia común (ITCC) según tramos de duración en España.
Métodos: Se consideraron casos de ITCC de la población afiliada de una mutua laboral. Se obtuvo la incidencia global de la incapacidad temporal por ITCC y por tramos de duración. Se realizó un estudio ecológico de series temporales considerando un punto de inflexión en 2013. Se calculó el porcentaje de cambio anual e intervalo de confianza del 95%. Los análisis se estratificaron por edad y sexo.
Resultados: La incidencia global pasó de 35,3 casos por cada 100 trabajadores-año en 2009 a 25,2 en 2013. A partir del 2014 se observa un ascenso sostenido de la incidencia de ITCC, finalizando el 2018 con 34,1 casos por cada 100 trabajadores-año. La incidencia global está determinada fundamentalmente por procesos menores a 16 días en población joven. El descenso en 2009-2013 se produjo en todos los tramos de duración, en especial en 4 a 15 (PCA=-11,2; IC 95%=(-14,1 a -8,2)) y más de 90 días (PCA=-9,4; IC 95%=(-15,5 a -2,8)), principalmente en jóvenes. El ascenso en 2013-2018 se observó en todos los tramos, siendo el incremento más significativo en tramos de 1-3 días (trabajadores de menor edad: PCA=18,9; IC 95%=(14,8 a 23,2)) y en más de 90 días (principalmente en mayores).
Conclusiones: La descripción temporal de la incidencia de ITCC por tramos de duración ofrece una información detallada de la incapacidad temporal.
Tezkire-i Şeyh Safî’deki -A ėr- Odaksıl Şimdiki Zaman İşaretleyicisi
Authors: TOKAT Feyza 
Published: April 2020

Türkçedeki odaksıl şimdiki zaman -(ı)yor ekinin, yorı- “yürümek” tasvir fiilinin yorır geniş zaman çekiminden hece yutumu ile oluştuğu ve aslında ayrı bir kelime olan
bu ekin sonradan ekleştiği genel olarak kabul görmüştür. Lars Johanson, bu genel görüşe katılmaz ve Azerbaycan Türkçesindeki şimdiki zaman işaretleyicisi {(y)Ir}’ın, büyük bir ihtimalle zarf-fiil + er-ür (er- ‘olmak’) biçiminde bir tasvirî fiilden geliyor olması gerektiğini söyler. Bu çalışmada Lars Johanson’un “büyük bir ihtimalle” diyerek belirttiği, fakat tanıklayamadığı -A ėr- şimdiki zaman ekinin örnekleri verilmiştir. Verilen örnekler İbn Bezzâz’ın Farsça Safvetu’s-Safâ adlı eserinden XVI. yüzyılda Neşâtî tarafından Azerbaycan sahasında Türkçeye çevrilen “Tezkire-i Şeyh Safî”den alınmıştır. Böylelikle, -A ėr- yapısı, Azerbaycan Türkçesinde odaksıl şimdiki zaman işaretleyicisi olarak ilk defa tanıklanmış olacaktır.
Optical limiting effect of C70 solution at 1064  nm
Authors: Wu Zhengnan , Lu Yuangang , Zuo Yujie , Xu Feng , Zuo Dunwen 
Published: April 2020

In this paper, we investigate the optical limiting effect of

C

70

solution at a wavelength of 1064 nm. We experimentally measured the transmittance of

C

70

solution under three different concentrations (0.25, 0.5, and 1 mmol/L), three different solution thicknesses (5, 10, and 20 mm), and two different solvents (toluene and xylene) and obtained the values of absorption cross sections and relaxation times in the five-level absorption model of

C

70

solution. The influences of concentration, thickness, and solvent on the optical limiting effect of the

C

70

solution are analyzed. We also measured transmittance of

C

60

solution under the same conditions and compared the results with those of

C

70

solution. The experimental results show that concentration and solution thicknesses have great influence on the optical limiting ability of

C

70

solution. The optical limiting effect of

C

70

solution is better than that of

C

60

solution at low concentration and worse than that of

C

60

solution at high concentration.
Tendencias bibliométricas de los resúmenes compilados en las memorias ACFO desde 2010-2017
Authors: Almario-Barrera Andrea Johana , Concha-Sánchez Sonia Constanza , Angarita Álvaro Andrés , Barón Jessica Vanessa , Sampayo Juan Pablo , Bueno Lisset Patricia , Arguello Julieth Paola , Álvarez Daniela Fernanda , Ardila Laura Juliana 
Published: April 2020

Objetivo: identificar las tendencias bibliométricas de los resúmenes publicados en las memorias del Encuentro Nacional de Investigación Odontológica (ENIO) de 2010 a 2017.Materiales y métodos: se realizó un análisis bibliométrico con todos los resúmenes compilados en las memorias mencionadas en el periodo de interés, excluyendo los trabajos presentados por el área de servicios, de estas se extrajo la información relacionada con el evento, indicadores de actividad y colaboración; esta información se sistematizó y procesó en Excel; se calcularon medidas de resumen según la naturaleza de las variables, que se presentaron en textos, tablas y gráficos; las adunas se obtuvieron mediante las aplicaciones VantagePoint y VOSViewer. Resultados: se identificaron 1135 resúmenes, la mayor proporción estaban registrados en el área clínica (43%). El 2,8% de los trabajos provenían de instituciones internacionales, el 47,9% de instituciones ubicadas en Bogotá, y el 0,8% eran proyectos multicéntricos. El 11,2% de las investigaciones las realizó la Universidad El Bosque, el 10,7% la Universidad Nacional de Colombia, el 10,1% la Institución Universitaria Colegios de Colombia; la Universidad Santo Tomás aportó el 5,6%. Predominaron los estudios observacionales (48%) y estudios In vitro (24,9%). La aduna muestra que los nodos con mayor número de autores los registra la Universidad el Bosque y con el menor la Universidad Nacional; al referir Instituciones, predomina la endogamia, pocos nodos muestran relación entre diferentes Universidades. Conclusión: se encontró predominio de la investigación en el área clínica, especialmente en temas de Patología, Rehabilitación Oral y Ortodoncia. En lo metodológico predominan los estudios epidemiológicos de corte transversal. Las Universidades que participaron con mayor número de investigaciones fueron El Bosque y la Universidad Nacional; se evidenciaron redes de colaboración débiles entre las facultades de odontología del país.
Excess — transgression — sanctity: analysis of St. Withelm’s life (according to The Lives of the Saints by Piotr Skarga)
Authors: Cybulska-Bohuszewicz Ewa 
Published: April 2020

The paper presents an analysis of the life of St. Wilhelm. It is based on The Lives of the Saints (Żywoty świetych) by Piotr Skarga published in Vilnius in 1579. The article is a development of earlier findings and researches on the phenomenon of transgression in The Lives of the Saints [Cybulska-Bohuszewicz 2018, 13–36]. As tools of analysis, it uses the concepts developed by thinkers such as Georges Bataille, Józef Kozielecki and Victor Turner. The work is innovative, because so far The Lives of the Saints has not been studied in this way. At the same time, the sketch is only a contribution to further research, culminating in a monograph devoted to the issues of transgression, sanctity and atopy in the work mentioned.
Phonetic Convergence in one Southeastern Part of Lithuania
Authors: Tuomienė Nijolė 
Published: April 2020

The present article addresses the principal phonetic phenomena of the languages used in borderland areas and their interaction. It analyzes of dialectological and sociolinguistic material collected from the end of the 20th century and the beginning of the 21st century from three points in the Šalčininkai district. It analyzes the phonetic convergence of the dominating local language varieties — Belarusian, Polish and Lithuanian — and establishes the tendencies of this process. The situations of natural communication in the context of code-switching are analyzed in the study: when the speakers are fluent and use several languages at the same time by actively switching between them in conversations.
The research is, based on the theory proposed by Valerijus Čekmonas, the researcher of the interaction of languages and Slavicist: the speaker switches between languages according to certain rules, which can be described by algorithms. Based on this method of algorithms, the study reveals the phonetic tendencies and proves a very important role and influence of the now passively used Lithuanian language on the articulation of contemporary Slavic languages.The research showed that the reasons of convergence of phonetic phenomena of the language varieties functioning in the borderland areas are mainly sociolinguistic. After comparing the phonetic peculiarities of local Polish and Belarusian dialects, it turned out that the phonetics of both dialects is essentially the same. The informants pronounce the soft consonants used in the local Lithuanian dialect in the same way as they are pronounced when speaking local Slavic dialects. The cases, which are not typical of Belarusian and Polish dialects, when consonants are intensively confused, were recorded; it is likely a feature of the Lithuanian substratum.
Immigration Discourse and the Prospects of Russian Language in Lithuania
Authors: Likhachiova Alla 
Published: April 2020

In contrast to the ongoing emigration, immigration to Lithuania cannot be called intensive, and this topic as a whole remains on the periphery of public and academic attention. This article offers a description of the situation of immigration from the perspective of sociolinguistics. In particular, an analysis of the discourse of today’s Russian-speaking immigration to Lithuania reveals the linguistic attitudes of immigrants with a native Russian language or their own, their adaptation strategies, family language planning, and, ultimately, makes it possible to formulate general conclusions about the prospects of preserving / not preserving Russian-speaking community in the host country.The paper summarizes interview materials with immigrants from Russia and some post-Soviet countries posted on the Lithuanian Internet, as well as recorded during this study.