bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants and Impact of Heart Failure Readmission Following Transcatheter Aortic Valve Replacement
Authors: Auffret Vincent , Bakhti Abdelkader , Leurent Guillaume , Bedossa Marc , Tomasi Jacques , Belhaj Soulami Reda , Verhoye Jean-Philippe , Donal Erwan , Galli Elena , Loirat Aurélie , Sharobeem Sam , Sost Gwenaelle , Le Guellec Marielle , Boulmier Dominique , Le Breton Hervé 
Published: June 2020

Background:
Heart failure (HF) readmission is common post–transcatheter aortic valve replacement (TAVR). Nonetheless, limited data are available regarding its predictors and clinical impact. This study evaluated the incidence, predictors, and impact of HF readmission within 1-year post-TAVR, and assessed the effects of the prescription of HF therapies at discharge on the risk of HF readmission and death.

Methods:
Patients included in the TAVR registry of a single expert center from 2009 to 2017 were analyzed. Competing-risk and Cox regressions were performed to identify predictors of HF readmission and death.

Results:
Among 750 patients, 102 (13.6%) were readmitted for HF within 1-year post-TAVR. Overall, 53 patients (7.1%) experienced late readmissions (>30 days post-TAVR), and 17 (2.3%) had multiple readmissions. In ≈30% of readmissions, no trigger could be identified. Predominant causes of readmissions were changes in medication/nonadherence and supraventricular arrhythmia. Independent predictors of HF readmission included diabetes mellitus, chronic lung disease, previous acute HF, grade III or IV aortic regurgitation, and pulmonary hypertension both at discharge from the index hospitalization but not HF therapies. Overall, HF readmission did not significantly impact all-cause mortality (hazard ratio [HR], 1.36 [95% CI, 0.99–1.85]). However, late (HR, 1.90 [95% CI, 1.30–2.78]) and multiple HF readmissions (HR, 2.10 [95% CI,1.17–3.76]) were significantly associated with all-cause mortality. Prescription of renin-angiotensin system inhibitors at discharge was associated with a lower rate of all-cause mortality, especially among patients receiving doses of 25% to <50% (HR, 0.67 [95% CI, 0.48–0.94]) and 75% to 100% (HR, 0.61 [95% CI, 0.37–0.98]) of the optimal daily dose.

Conclusions:
HF readmission is common within 1-year of TAVR. Late and multiple HF readmissions associate with an increased risk of long-term all-cause mortality. Baseline comorbidities (diabetes, chronic lung disease, previous acute HF) and echocardiographic findings at discharge (grade III or IV aortic regurgitation, pulmonary hypertension) identified patients at high risk of HF readmission.
Combined Influence of Waist and Hip Circumference on Risk of Death in a Large Cohort of European and Australian Adults
Authors: Cameron Adrian J. , Romaniuk Helena , Orellana Liliana , Dallongeville Jean , Dobson Annette J. , Drygas Wojciech , Ferrario Marco , Ferrieres Jean , Giampaoli Simona , Gianfagna Francesco , Iacoviello Licia , Jousilahti Pekka , Kee Frank , Moitry Marie , Niiranen Teemu J. , Pająk Andrzej , Palmieri Luigi , Palosaari Tarja , Satu Männistö , Tamosiunas Abdonas , Thorand Barbara , Toft Ulla , Vanuzzo Diego , Veikko Salomaa , Veronesi Giovanni , Wilsgaard Tom , Kuulasmaa Kari , Söderberg Stefan 
Published: June 2020

Background
Waist circumference and hip circumference are both strongly associated with risk of death; however, their joint association has rarely been investigated.

Methods and Results

The MONICA Risk, Genetics, Archiving, and Monograph (MORGAM) Project was conducted in 30 cohorts from 11 countries; 90 487 men and women, aged 30 to 74 years, predominantly white, with no history of cardiovascular disease, were recruited in 1986 to 2010 and followed up for up to 24 years. Hazard ratios were estimated using sex‐specific Cox models, stratified by cohort, with age as the time scale. Models included baseline categorical obesity measures, age, total and high‐density lipoprotein cholesterol, systolic blood pressure
,
antihypertensive drugs, smoking, and diabetes mellitus. A total of 9105 all‐cause deaths were recorded during a median follow‐up of 10 years. Hazard ratios for all‐cause death presented J‐ or U‐shaped associations with most obesity measures. With waist and hip circumference included in the same model, for all hip sizes, having a smaller waist was strongly associated with lower risk of death, except for men with the smallest hips. In addition, among those with smaller waists, hip size was strongly negatively associated with risk of death, with ≈20% more people identified as being at increased risk compared with waist circumference alone.

Conclusions
A more complex relationship between hip circumference, waist circumference, and risk of death is revealed when both measures are considered simultaneously. This is particularly true for individuals with smaller waists, where having larger hips was protective. Considering both waist and hip circumference in the clinical setting could help to best identify those at increased risk of death.
Computer‐Assisted Quantitative Analysis of Drug‐Induced Sleep Endoscopy for Obstructive Sleep Apnea/Hypopnea Syndrome
Authors: Lai Chi‐Chih , Lin Pei‐Wen , Lin Hsin‐Ching , Friedman Michael , Salapatas Anna M. , Chen Ju‐Pin , Chang Hsueh‐Wen , Juang Sin‐Ei , Wu Shao‐Chun , Lin Meng‐Chih 
Published: June 2020

ObjectivesTo use computer‐assisted quantitative measurements of upper airway changes during drug‐induced sleep endoscopy (DISE) and to correlate these parameters with disease severities and physiologic changes in patients with obstructive sleep apnea/hypopnea syndrome (OSA).DesignA retrospective study.SettingTertiary academic medical center.Patients and MethodsA total of 170 patients who failed continuous positive airway pressure therapy and then underwent upper airway surgery were enrolled. All patients received polysomnography and DISE preoperatively. We used ImageJ 1.48v to obtain maximal and minimal measurements, including cross‐sectional areas and anterior‐posterior and lateral diameters at 4 anatomic levels (retropalatal, oropharyngeal, retroglossal, and retroepiglottic) under DISE, and then computed the percentage changes. We analyzed the clinical values of DISE changes by computer‐assisted analysis in patients with OSA and any correlations between these changes and polysomnography parameters.ResultsThe percentage changes of upper airway showed significant collapses at all 4 anatomic levels (all P <. 0001). We also found that the changes at retropalatal levels were significantly greater and that retroglossal levels were significantly smaller, while the changes of anterior‐posterior diameters at retroglossal levels showed a significant positive association with apnea‐hypopnea index and desaturation index. However, there were no statistically significant correlations between upper airway changes and obesity.ConclusionComputer‐assisted quantitative analysis could evaluate upper airway changes of OSA in an objective way and may help identify the sites of obstruction during DISE more accurately. Upper airway showed multilevel collapse with independent significant changes in patients with OSA, with the retropalatal and retroglossal levels playing important roles in particular.
Comparison of Endoscopic and Ultrasonographic Measurements of the Subglottic Airway in Children
Authors: Lambert Elton M. , Tran Huy D. , Ongkasuwan Julina 
Published: June 2020

ObjectiveTo compare measurements of the pediatric subglottis obtained by surgeon‐performed ultrasound and endoscopy.Study DesignProspective observational comparison‐of‐methods study.SettingTertiary care pediatric hospital.Subjects and MethodsThirty‐one patients who underwent direct laryngoscopy from May 2017 to July 2018 were recruited. Transcervical ultrasound was used to visualize the vocal folds, subglottis, and cervical trachea. The anterior‐posterior (AP) and transverse (TV) diameter of the subglottic space were measured endoscopically and via ultrasound by 2 independent evaluators. Measurements were compared for correlation, bias, and agreement. A clinically acceptable bias for subglottic diameter was assumed to be 0.5 mm or less.ResultsThe median age of enrolled patients was 2.6 years (range, 4 months–13.3 years). Endoscopic subglottic AP and TV measurements ranged from 3.33 mm to 14.81 mm and from 4.44 mm to 11.65 mm, respectively, while ultrasonographic AP and TV measurements ranged from 4.57 mm to 9.85 mm and from 3.77 mm to 8.96 mm. Pearson coefficient showed strong a correlation for both endoscopic and ultrasound AP (R = 0.8081, P <. 0001) and TV (R = 0.8796, P <. 001) measurements of the subglottis. Bland‐Altman plots revealed a bias (average discrepancy) for AP measurements of 0.22 mm and 0.11 mm for TV measurements.ConclusionEndoscopic and ultrasonography measurements of the pediatric subglottic airway were strongly correlated. The discrepancy between AP and TV measurements was less than 0.5 mm. Ultrasound of the subglottis may be an alternative to endoscopic assessment of the airway for measurement of the subglottic airway in children in select cases.
Early Data From Case Series of Tracheostomy in Patients With SARS‐CoV‐2
Authors: Floyd Elizabeth , Harris Scott S. , Lim Jessica W. , Edelstein David R. , Filangeri Briana , Bruni Margherita 
Published: June 2020

Thirty‐eight tracheostomies were performed on patients with respiratory failure secondary to SARS‐CoV‐2 infection over the month of April at North Shore University Hospital and Lenox Hill Hospital (members of Northwell Health System in Long Island and New York City). Follow‐up by May 14 revealed that 21 (55.2%) had been weaned from ventilators and 7 (18.4%) underwent decannulation. Two patients (5.3%) expired in the weeks following tracheostomy. Between the 2 institutions, 10 attending surgeons performed all of the tracheostomies using appropriate personal protective equipment, and none demonstrated seroconversion within 1 to 2 weeks of this article.
Supervision Satisfaction Among Social Work Students in Israel: Supervision Components, Peer Support, and Trauma-Related Factors
Authors: Reuven Even Zahav Ronit , Refaeli Tehila , Shemesh Shahar , Gottlieb Shelly , Ben-Porat Anat 
Published: June 2020

Purpose: Supervision is an essential part of social work education. Accordingly, supervision satisfaction plays an important role in the development of the students’ professional identity. However, the factors contributing to supervision satisfaction among social work students have rarely been examined. This study examined the contribution of supervision components, peer support, secondary traumatization, and vicarious post-traumatic growth (VPTG) to supervision satisfaction. Method: Self-report questionnaires were distributed to 259 undergraduate social work students. Correlation and hierarchical linear regression analyses were performed. Results: Higher supervision satisfaction was predicted by the educational and supportive components of supervision, peer support, and VPTG, whereas the administrative component of supervision satisfaction and secondary traumatization predicted lower supervision satisfaction. Discussion: The findings highlight the negative ramifications of secondary traumatization and the positive contribution that supportive and educational supervision, peer support, and VPTG can have on social work students’ supervision satisfaction. Practical implications for practice and policy are discussed.
High-pressure densification and hydrophobic coating for enhancing the mechanical properties and dimensional stability of soft poplar wood boards
Authors: Yu Yong , Li Aqiang , Yan Kaiya , Ramaswamy Hosahalli S. , Zhu Songming , Li Huanhuan 
Published: June 2020

AbstractEffects of high-pressure (HP) treatment on densification of poplar sapwood boards and subsequent coatings were evaluated. Tung oil (TO) and epoxy resin (ER)-coated treatments were used to improve the dimensional stability of HP-densified wood. The density of the wood after HP densification increased from 450 ± 50 kg/m3 for the control to 960 ± 20 kg/m3 at 125 MPa. This process also resulted in the average thickness of HP-densified boards to reduce significantly from 29.7 ± 0.11 mm for the control to 18.8 ± 0.53 mm after HP densification at 25 MPa and 14.3 ± 0.10 mm after 125 MPa treatment for 30 s. The mechanical strength measured as the hardness of densified wood significantly increased from 35% at 25 MPa to 96% at 125 MPa treatment, compared to untreated wood. As expected both TO and ER-coated treatments significantly reduced set-recovery of densified wood when stored at four relative humidity environments. ER showed better anti-swelling performance than TO, and would be a better choice.
New quantitative trait locus (QTLs) and candidate genes associated with the grape berry color trait identified based on a high-density genetic map
Authors: Sun Lei , Li Shenchang , Jiang Jianfu , Tang Xiaoping , Fan Xiucai , Zhang Ying , Liu Jihong , Liu Chonghuai 
Published: June 2020

Abstract
Background
Berry color is an important trait in grapes and is mainly determined by the anthocyanin content and composition. To further explore the coloring mechanism of grape berries, the F1 population of Vitis vinifera ‘Red Globe’ × ‘Muscat Hamburg’ was used to map the color locus, and transcriptome analysis was performed to assist in screening candidate genes.

Results
A total of 438,407 high-quality single-nucleotide polymorphisms (SNPs) were obtained from whole-genome resequencing (WGS) of the population, and 27,454 SNPs were selected to construct a high-density genetic map. The selected SNPs were clustered into 19 linkage groups (LGs) spanning a genetic distance of 1442.638 cM. Berry color was evaluated by color grade, chromatic aberration, total anthocyanin content and anthocyanin composition. The Pearson correlation coefficients of these phenotypes in 2017 and 2018 were significant at the 0.01 level. The major color locus of MYBA1 and MYBA2 on LG2 was identified, explaining between 26 and 63.6% of all phenotypic variance. Furthermore, 9 additional QTLs with smaller effects were detected on Chr2, Chr4, Chr6, Chr11 and Chr17. Combined with the gene annotation and RNA-seq data, multiple new candidate genes were selected from the above QTLs.

Conclusion
These results indicated that grape berry color is a quantitative trait controlled by a major color locus and multiple minor loci. Though the major color locus was consistent with previous studies, several minor QTLs and candidate genes associated with grape berry color and anthocyanin accumulation were identified in this study. And the specific regulatory mechanism still needs to be further explored.
Prevalence and risk factors for bone loss in Southern Chinese with rheumatic diseases
Authors: Hu Zhuoran , Xu Shuiming , Lin He , Ni Weifeng , Yang Qingyuan , Qi Jun , Du Keqian , Gu Jieruo , Lin Zhiming 
Published: June 2020

Abstract
Backgroud
This study is to explore the prevalence of different stages of bone loss and the potential risk factors in rheumatic patients.

Method
A cross-sectional study recruits 1398 rheumatic patients and 302 healthy subjects. Demographic data, blood, and bone mineral density (BMD) tests are collected. Risk factors for bone loss in rheumatic patients are analyzed by logistic regression.

Results
(1) Rheumatic patients are consisted of 40.0% rheumatoid arthritis (RA), 14.7% systemic lupus erythematosus (SLE), 14.2% osteoarthritis (OA), 9.2% ankylosing spondylosis (AS), 7.9% gout, 7.0% primary Sjogren syndrome (pSS), 3.8% systemic sclerosis (SSc), and 3.2% mixed connective tissue disease (MCTD). (2) In male patients aged under 50 and premenopausal female patients, the bone mineral density score of AS (53.9%, P < 0.001) and SLE (39.6%, P = 0.034) patients is lower than the healthy controls (18.2%). (3) Osteopenia and osteoporosis are more prevailing in male patients aged or older than 50 and postmenopausal female patients with RA (P < 0.001), OA (P = 0.02) and SLE (P = 0.011) than healthy counterparts. (4) Those with SLE, RA and AS gain the highest odd ratio of ‘score below the expected range for age’, osteopenia and osteoporosis, respectively. (5) Age, female, low BMI and hypovitaminosis D are found negatively associated with bone loss. Dyslipidemia and hyperuricemia could be protective factors.

Conclusion
Young patients with AS and SLE have a significant higher occurrence of bone loss, and older patients with RA, OA and SLE had higher prevalence than healthy counterparts. SLE, RA, SSc and AS were founded significant higher risks to develop into bone loss after adjustment. Age, BMI and gender were commonly-associated with bone loss in all age-stratified rheumatic patients. These findings were not markedly different from those of previous studies.
Serosurvey of arthropod-borne diseases among shelter dogs in the Cumberland Gap Region of the United States
Authors: Patterson Gilbert , Tanhauser Matthew , Schmidt Paul , Spangler Dawn , Faulkner Charles , Faulkner Vina , Kish Daniel , Gruszynski Karen , Naikare Hemant , Coarsey Michele D. , Verma Ashutosh 
Published: June 2020

AbstractBackgroundThe Cumberland Gap Region (CGR) of the United States is a natural corridor between the southeastern, northeastern, and midwestern regions of the country. CGR has also many species of ticks and mosquitos that serve as competent vectors for important animal and human pathogens. In this study, we tested dogs from six different animal shelters in the CGR for Rocky Mountain spotted fever (RMSF), anaplasmosis, Lyme disease, canine ehrlichiosis and canine heartworm disease.ResultsSera from 157 shelter dogs were tested for antibodies to RMSF agent,Rickettsia rickettsii, using an indirect immunofluorescence assay. Sixty-six dogs (42.0%) were positive for either IgM or IgG, or both IgM and IgG antibodies toR. rickettsii. Moreover, the same set of sera (n = 157) plus an and additional sera (n = 75) from resident dogs at the same shelters were tested using the SNAP 4Dx Plus. Of 232 dogs tested, two (0.9%) were positive for antibodies toAnaplasma phagocytophilum/A. platys, nine (3.9%) were positive for antibodies toBorrelia burgdorferi, 23 (9.9%) for positive for antibodies toEhrlichia canis/E. ewingii, and 13 (5.6%) were positive forDirofilaria immitisantigen. Co-infection with two or more etiologic agents was detected in five animals. Three dogs had antibodies to bothB. burgdorferiandE. canis/E. ewingii, and two dogs were positive forD. immitisantigen and antibodies toB. burgdorferiandE. canis/E. ewingii.ConclusionsShelter dogs in the CGR are exposed to a number of important vector-borne pathogens. Further studies are required to ascertain the roles these animals play in maintenance and transmission of these pathogens.
Systematic review with network meta-analysis of randomized controlled trials of robotic-assisted arm training for improving activities of daily living and upper limb function after stroke
Authors: Mehrholz Jan , Pollock Alex , Pohl Marcus , Kugler Joachim , Elsner Bernhard 
Published: June 2020

AbstractBackgroundThe aim of the present study was to to assess the relative effectiveness of the various types of electromechanical-assisted arm devices and approaches after stroke.MethodThis is a systematic review of randomized controlled trials with network meta-analysis. Our primary endpoints were activities of daily living (measured e.g. with Barthel-Index) and hand-arm function (measured e.g. with the Fugl-Meyer Scale for the upper limb), our secondary endpoints were hand-arm strength (measured e.g. with the Motricity Index) and safety. We used conventional arm training as our reference category and compared it with different intervention categories of electromechanical-assisted arm training depending on the therapy approach. We did indirect comparisons between the type of robotic device. We considered the heterogeneity of the studies by means of confidence and prediction intervals.ResultsFifty five randomized controlled trials, including 2654 patients with stroke, met our inclusion criteria.For the primary endpoints activities of daily living and hand-arm function and the secondary endpoint hand-arm strength, none of the interventions achieved statistically significant improvements, taking into account the heterogeneity of the studies.Safety did not differ with regard to the individual interventions of arm rehabilitation after stroke.ConclusionThe outcomes of robotic-assisted arm training were comparable with conventional therapy.Indirect comparisons suggest that no one type of robotic device is any better or worse than any other device, providing no clear evidence to support the selection of specific types of robotic device to promote hand-arm recovery.Trial registrationPROSPERO 2017CRD42017075411
Uptake and predictors of direct-acting antiviral treatment for hepatitis C among people receiving opioid agonist therapy in Sweden and Norway: a drug utilization study from 2014 to 2017
Authors: Aas Christer F. , Vold Jørn Henrik , Skurtveit Svetlana , Odsbu Ingvild , Chalabianloo Fatemeh , Lim Aaron G. , Johansson Kjell Arne , Fadnes Lars Thore 
Published: June 2020

Abstract
Background
Treatment with direct-acting antiviral agents (DAAs) offers an opportunity to eliminate hepatitis C virus (HCV) endemic among people who inject drugs (PWID) and people enrolled in opioid agonist therapy (OAT) programs. The objective of this study was to estimate and to compare HCV treatment uptake after the introduction of DAAs among patients receiving OAT in Sweden and Norway. We also aimed to evaluate predictors of DAAs treatment among OAT patients in both countries.

Methods
This observational study was conducted with data from The Swedish Prescribed Drug Register and The Norwegian Prescription Database. We studied dispensed medications to calculate HCV treatment among OAT patients from 2014 to 2017 in Sweden and Norway. HCV prevalence was estimated from primary and secondary sources. Dispensations of medicines from different therapeutic areas, which served as proxy for co-morbidities in 2017, were conditionally adjusted for age, gender, and OAT medications. Logistic regression was used to evaluate these parameters.

Results
In total 3529 individuals were identified with dispensed OAT in the Swedish cohort and 7739 individuals in the Norwegian cohort. HCV treatment was utilized by 407 persons in Sweden and 920 in Norway during the study period. Annual HCV and DAA treatment uptake increased in both countries. The estimated cumulative HCV treatment uptake at the end of 2017 was 31% in Norway and 28% in Sweden. DAA treatment was associated with increased age (aOR 1.8; 95% CI 1.0–3.2) and the dispensation of drugs used for diabetes (aOR 3.2; 95% CI 1.8–5.7) in Sweden. In Norway, lipid modifying agents and antibacterials were associated with decreased odds (aOR 0.4; 95%CI 0.2–0.9, aOR 0.8; 95%CI 0.6–1.0).

Conclusions
An increase in DAA treatment and HCV treatment uptake was observed among Swedish and Norwegian OAT patients whilst introducing new direct-acting antiviral treatment regimens. However, more than two thirds of the OAT population in Norway and Sweden were untreated at the beginning of 2018. A further scale-up is crucial in order to control and eliminate the HCV endemic among OAT patients.