bluuebunny/crossref_metadata_2025_split huggingface dataset:
European knowledge and entrepreneurial ecosystems: Networks within climate change and adaptation research
Authors: Carrozza Chiara , Cruz Ana Rita , Nogueira Carla , Pinto Hugo , Uyarra Elvira 
Published: July 2020

AbstractResearch on a topic as intricate as climate change and adaptation can be seen as a complex ecosystem combining thousands of projects by a large set of actors. This article studies the EU Seventh Framework Program funded projects to understand how research has been funded and managed in Europe to develop a specific knowledge ecosystem around climate change and adaptation. The theoretical background offers an overview of the topics of climate change and knowledge ecosystems. The research projects database was used to construct and make sense of a complex ecosystem. A synthetic description of the technical work conducted and the results obtained are presented. The data is analyzed using social network analysis to provide evidence of structural characteristics of the networks, the relevance of different sub‐domains in climate change and adaptation research, and the emergence of entrepreneurial ecosystems through knowledge.
The toll of household water insecurity on health and human biology: Current understandings and future directions
Authors: Rosinger Asher Y. , Young Sera L. 
Published: July 2020

AbstractWater is imperative for nutrition and health, economic productivity, and political stability; it also holds cultural and symbolic meanings and functions. Household water insecurity is an emerging construct that captures lived experiences with water access, use, and acceptability. Although the plausibility of household water insecurity to “get under the skin” and shape human biology is high, these relationships have not been systematically investigated. Therefore, in this article, we set out to examine how household water insecurity and allied concepts affect health and human biology throughout the life course. We first lay out the various ways that water insecurity can act as a deleterious exposure, that is, through problematic quality, excess, and shortage. Next, we posit how water insecurity directly shapes human biology, as well as indirectly, via psychosocial stress precipitating cortisol exposure, with potential intergenerational effects. We highlight a range of established and plausible biological consequences using evidence from human and animal model studies. These include diarrheal prevalence, dehydration, stunting, food insecurity, gut microbiome alteration, malnutrition, psychosocial stress, adverse birth outcomes, lower cognitive function and performance, hypertension, and chronic kidney disease. We also discuss the mechanisms by which household water insecurity may shape human biology across the life course; however, these pathways are just beginning to be understood. Longitudinal studies that simultaneously quantify household water insecurity and biological outcomes using comparable metrics in diverse environments and across generations will provide necessary evidence to establish causal relationships. Given the current global water crisis and its potential health consequences, such studies are urgently needed.This article is categorized under:Engineering Water > Water, Health, and SanitationScience of Water > Water Quality
Effects of pollution on marine organisms
Authors: Mearns Alan J. , Morrison Ann Michelle , Arthur Courtney , Rutherford Nicolle , Bissell Matt , Rempel‐Hester Mary Ann 
Published: July 2020

AbstractThis review covers selected 2019 articles on the biological effects of pollutants, including human physical disturbances, on marine and estuarine plants, animals, ecosystems, and habitats. The review, based largely on journal articles, covers field, and laboratory measurement activities (bioaccumulation of contaminants, field assessment surveys, toxicity testing, and biomarkers) as well as pollution issues of current interest including endocrine disrupters, emerging contaminants, wastewater discharges, marine debris, dredging, and disposal. Special emphasis is placed on effects of oil spills and marine debris due largely to the 2010 Deepwater Horizon oil blowout in the Gulf of Mexico and proliferation of data on the assimilation and effects of marine debris microparticulates. Several topical areas reviewed in the past (e.g., mass mortalities ocean acidification) were dropped this year. The focus of this review is on effects, not on pollutant sources, chemistry, fate, or transport. There is considerable overlap across subject areas (e.g., some bioaccumulation data may be appeared in other topical categories such as effects of wastewater discharges, or biomarker studies appearing in oil toxicity literature). Therefore, we strongly urge readers to use keyword searching of the text and references to locate related but distributed information. Although nearly 400 papers are cited, these now represent a fraction of the literature on these subjects. Use this review mainly as a starting point. And please consult the original papers before citing them.
The pure BRST Einstein-Hilbert Lagrangian from the double-copy to cubic order
Authors: Borsten L. , Nagy S. 
Published: July 2020

Abstract
We construct the pure gravity Becchi-Rouet-Stora-Tyutin (BRST) Einstein-Hilbert Lagrangian, to cubic order, using the BRST convolution product of two Yang-Mills theories, in conjunction with the Bern-Carrasco-Johansson (BCJ) double-copy.
Endoscopic submucosal dissection with an additional working channel (ESD+): a novel technique to improve procedure time and safety of ESD
Authors: Knoop Richard F. , Wedi Edris , Petzold Golo , Bremer Sebastian C. B. , Amanzada Ahmad , Ellenrieder Volker , Neesse Albrecht , Kunsch Steffen 
Published: July 2020

Abstract
Background and aims
A new external additional working channel (AWC) was recently introduced by which endoscopic submucosal dissection (ESD) can be converted to a technique termed “ESD+ ”. We aim to systematically evaluate this novel technique in flat gastric lesions and compare it to classical ESD.

Methods
The study was prospectively conducted in a pre-clinical ex vivo animal model (EASIE-R simulator) with porcine stomachs. Prior to intervention, we set standardized lesions measuring 3 cm or 4 cm in antegrade as well as in retrograde positions.

Results
Overall, 64 procedures were performed by an experienced endoscopist. Both techniques were reliable and showed en bloc resection rates of 100%. Overall, ESD+ reduced time of procedure compared to ESD (24.5 vs. 32.5 min, p = 0.025*). Particularly, ESD+ was significantly faster in retrograde lesions with a median of 22.5 vs. 34.0 min in 3 cm retrograde lesions (p = 0.002*) and 34.5 vs. 41.0 min (p = 0.011*) in 4 cm retrograde lesions. There were 0 perforations with both techniques. In ESD+ , 1 muscularis damage occurred (3.13%) compared to 6 muscularis damages with ESD (18.75%, p = 0.045*).

Conclusions
By its grasp-and-mobilize technique, ESD+ allows potentially faster and safer resections of flat gastric lesions compared to conventional ESD in an ex vivo porcine model. The potential advantages of ESD+ in terms of procedure time may be particularly relevant for difficult lesions in retrograde positions.
Identification of an oral microbiota signature associated with an impaired orosensory perception of lipids in insulin-resistant patients
Authors: Besnard Philippe , Christensen Jeffrey E. , Bernard Arnaud , Simoneau-Robin Isabelle , Collet Xavier , Verges Bruno , Burcelin Rémy 
Published: July 2020

Abstract
Aims
Type 2 diabetes leads to multiple sensory dysfunctions affecting notably the gustatory sensitivity. Although this sensory defect, by impacting food choices, might lead to unhealthy eating behavior, underlying mechanisms remains poorly studied. We have recently reported that the composition of microbiota in contact with circumvallate gustatory papillae might affect the orosensory perception of lipids in lean and normoglycemic obese subjects. This finding has prompted us to explore whether such a phenomenon also occurs in diabetic obese patients.

Methods
The composition of microbiota surrounding the circumvallate papillae was analyzed in combination with the linoleic acid perception thresholds in male insulin-resistant patients and weight-matched healthy controls. Two complementary comparisons were performed: (1) controls vs diabetic and (2) diabetic low-lipid tasters versus diabetic high-lipid tasters.

Results
Despite subtle modifications in the oral microbiota composition, comparison of orosensory lipid perception in controls and diabetic subjects did not lead to discriminating data due to the large inter-individual variability of linoleic acid perception thresholds. In contrast, specific bacterial signatures were found by comparing diabetic low- and high-lipid tasters leading to differential molecular pathways. Surprisingly, a lower fatty taste perception was mainly found in patients treated with metformin and/or statins, suggesting a possible side effect of these antidiabetic and/or hypolipidemic drugs on taste acuity.

Conclusions
Collectively, these data show that the diabetic patients with defective fatty taste detection are characterized by a specific microbiota metabolism at the circumvallate papillae levels, this occurrence seeming amplified by drugs commonly used to counteract the damaging metabolic effects of T2D.
Trial registration for original previous studies: ClinicalTrials.gov #NCT02028975
Validation of the revised Amyotrophic Lateral Sclerosis Functional Rating Scale in Poland and its reliability in conditions of the medical experiment
Authors: Maksymowicz Stanisław , Kukołowicz Paula , Siwek Tomasz , Rakowska Agnieszka 
Published: July 2020

Abstract
Introduction
Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) is a basic tool for monitoring disease progression in amyotrophic lateral sclerosis (ALS). This study analyses the reliability of the Polish version of the ALSFRS-R as a tool to assess the health condition of patients with ALS and presents experience related to the use of this tool in monitoring the effects of experimental medical therapy.

Materials and methods
The scale questionnaire was translated using the cross-translation method. The final tool was used by researcher, who was conducting the interview directly by telephone with patients and their caregivers and additionally compared with neurologopedic measurement. The health status of 60 patients was assessed between 4 and 7 times, which gives a total of 327 observations. Mean patient’s age was 57.5 ± 8.6. The division by sex was 23/35 (female/male). Patients’ health status and severity of symptoms varied. Statistical analysis was performed using explanatory factor analysis and Cronbach’s alpha.

Result
Validation of the Polish version of the ALSFRS-R supports the reliability and internal consistency of scale. The scale proved also to be a proper tool for monitoring the course of the experimental medical therapy for patients with ALS. However, a qualitative evaluation revealed certain weaknesses of the scale, resulting from a different understanding of the functional assessment by the patient and by the medical specialist and cultural differences.

Discussion
Although ALSFRS-R is a reliable enough for monitoring patient health, it seems reasonable to pay attention to some difficult points of the questionnaire and its improvement.
General surgeons’ attitudes towards COVID-19
Authors: Rymarowicz Justyna , Stefura Tomasz , Major Piotr , Szeliga Jacek , Wallner Grzegorz , Nowakowski Michał , Pędziwiatr Michał 
Published: July 2020

Summary
Background
The COVID-19 global pandemic left the unprepared health care systems struggling to mount a measured response. This gave rise to important questions about surgeons’ attitude towards surgical practice and the level of preparation at work.

Methods
Cross-sectional web-based national survey distributed to general surgeons by e‑mail over a period of 7 days.

Results
Among 304 responders, 42.6% were working in the hospital with COVID-19 patients. Three quarters of all surgeons (74.5%) were afraid of contracting the disease. While 42% expressed a fear for their own life while caring for COVID-19 patients, 90.1% were afraid of transmitting the disease to family members. The average reported level of PPE provided at the workplace was significantly higher among the group which was not afraid of contracting COVID-19 than among the group afraid of contracting COVID-19 (4.0 vs. 3.12, p = 0.02). Nearly all surgeons (93.8%) agreed that cancer surgeries should be continued during the pandemic and 49% perceived laparoscopy as a safe approach when operating on COVID-19 positive patients.

Conclusion
A high proportion of surgeons admitted being afraid of working during the COVID-19 pandemic, which had various implications for their attitude towards surgical practice. Protecting health care workers is an important component of public health measures for addressing the epidemic
To appease or to repress: how dictators use economic dynamics to increase their regime longevity
Authors: Harrijvan Merel , Weerdesteijn Maartje 
Published: July 2020

AbstractInternational crimes, such as genocide, crimes against humanity, and war crimes, are more likely to occur in non-democratic regimes. Consequently, the decision-making process of dictators has increasingly garnered criminological interest [78]. The decisions dictators make and the strategies they use impact the longevity of their regime. Scholars predominantly focus on the extent to which a dictator is able to generate support from both the elite and the masses in explaining regime survival [3, 22, 54]. A dictator can use economic dynamics to increase his support among the elite through corrupt practices [3], he can determine the extent to which he is supported by the masses by offering public goods and services to them [22] and he can withhold benefits to repress threats stemming from these groups [17]. However, the intentional use of these strategies to increase regime survival remains under-researched [77]. The present research aims to fill this gap through an analysis of Paul Biya’s 37-year reign in Cameroon. It is argued that the economic structure of a country influences the strategy—repression or appeasement—that is chosen to deal with the threat stemming from the masses or the elite and that ultimately, these considerations are likely to influence the economic development of a country.
Selenium biofortification in the 21st century: status and challenges for healthy human nutrition
Authors: Schiavon Michela , Nardi Serenella , dalla Vecchia Francesca , Ertani Andrea 
Published: July 2020

Abstract
Background
Selenium (Se) is an essential element for mammals and its deficiency in the diet is a global problem. Plants accumulate Se and thus represent a major source of Se to consumers. Agronomic biofortification intends to enrich crops with Se in order to secure its adequate supply by people.

Scope
The goal of this review is to report the present knowledge of the distribution and processes of Se in soil and at the plant-soil interface, and of Se behaviour inside the plant in terms of biofortification. It aims to unravel the Se metabolic pathways that affect the nutritional value of edible plant products, various Se biofortification strategies in challenging environments, as well as the impact of Se-enriched food on human health.

Conclusions
Agronomic biofortification and breeding are prevalent strategies for battling Se deficiency. Future research addresses nanosized Se biofortification, crop enrichment with multiple micronutrients, microbial-integrated agronomic biofortification, and optimization of Se biofortification in adverse conditions. Biofortified food of superior nutritional quality may be created, enriched with healthy Se-compounds, as well as several other valuable phytochemicals. Whether such a food source might be used as nutritional intervention for recently emerged coronavirus infections is a relevant question that deserves investigation.
Recommendations on how to provide cardiac rehabilitation services during the COVID-19 pandemic
Authors: Kemps H. M. C. , Brouwers R. W. M. , Cramer M. J. , Jorstad H. T. , de Kluiver E. P. , Kraaijenhagen R. A. , Kuijpers P. M. J. C. , van der Linde M. R. , de Melker E. , Rodrigo S. F. , Spee R. F. , Sunamura M. , Vromen T. , Wittekoek M. E. ,   Committee for Cardiovascular Prevention and Cardiac Rehabilitation of the Netherlands Society of Cardiology, Kemps H. M. C. , Brouwers R. W. M. , Cramer M. J. , Jorstad H. T. , de Kluiver E. P. , Kraaijenhagen R. A. , Kuijpers P. M. J. C. , van der Linde M. R. , de Melker E. , Rodrigo S. F. , Spee R. F. , Sunamura M. , Vromen T. , Wittekoek M. E. 
Published: July 2020

AbstractThe ongoing coronavirus disease 2019 (COVID-19) crisis is having a large impact on acute and chronic cardiac care. Due to public health measures and the reorganisation of outpatient cardiac care, traditional centre-based cardiac rehabilitation is currently almost impossible. In addition, public health measures are having a potentially negative impact on lifestyle behaviour and general well-being. Therefore, the Working Group of Cardiovascular Prevention and Rehabilitation of the Dutch Society of Cardiology has formulated practical recommendations for the provision of cardiac rehabilitation during the COVID-19 pandemic, by using telerehabilitation programmes without face-to-face contact based on current guidelines supplemented with new insights and experiences.
A short review of green extraction technologies for rice bran oil
Authors: Fraterrigo Garofalo Silvia , Tommasi Tonia , Fino Debora 
Published: July 2020

AbstractRice is one of the most important crops throughout the world, as it contributes toward satisfying the food demand of much of the global population. It is well known that rice production generates a considerable number of by-products, among which rice bran deserves particular attention. This by-product is exceptionally rich in nutrients, since it contains a wide spectrum of macronutrients (proteins, fats, carbohydrates) as well as dietary fibers and bioactive compounds. However, rice bran is usually wasted or just used for the production of low-cost products. The lipidic fraction of rice bran contains an unsaponifiable fraction that is rich in such functional components as tocopherols, γ-oryzanol, tocotrienols, and phytosterols. This lipidic fraction can be extracted to obtain rice bran oil (RBO), a high value-added product with unique health properties as a result of its high concentration in γ-oryzanol, a powerful antioxidant mixture of bioactive molecules. Conventional extraction methods employ hexane as the solvent, but these methods suffer from some drawbacks linked to the toxicity of hexane for humans and the environment. The aim of the review presented herein is to point out the new green technologies currently applied for the extraction of RBO, by highlighting reliable alternatives to conventional solvent extraction methods that are in line with the twelve principles of green chemistry and a circular economy.
Renal pathological analysis using galactose-deficient IgA1-specific monoclonal antibody is a strong tool for differentiation of primary IgA nephropathy from secondary IgA nephropathy
Authors: Lee Mingfeng , Suzuki Hitoshi , Kato Rina , Fukao Yusuke , Nakayama Maiko , Kano Toshiki , Makita Yuko , Suzuki Yusuke 
Published: July 2020

AbstractIn several cases with IgA nephropathy (IgAN), differential diagnosis is difficult due to the complication with other systemic diseases which can induce secondary IgAN. Recently, we demonstrated that immunostaining with galactose-deficient IgA1-specific monoclonal antibody (KM55 mAb) specifically showed positive in primary IgAN cases. Here, we report four cases which we could make definitive diagnosis by immunohistological analysis using KM55 mAb. The underlying systemic diseases are rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), hepatitis C (HCV) and Crohn’s disease (CD). Renal pathological findings in the four cases revealed mesangial proliferative glomerulonephritis with IgA and C3 deposits. Immunostaining with KM55 mAb was positive for three cases complicated with RA, SLE and CD, respectively. Thus, these three cases were diagnosed as primary IgAN and treated with tonsillectomy and steroid pulse therapy. These three cases finally achieved clinical remission. On the other hand, the case with HCV showed negative for KM55. Finally, we diagnosed as HCV-related nephropathy and successfully treated by antiviral agents. These cases suggested KM55 mAb is a strong tool to differentiate primary IgAN from secondary IgAN.
Sexual Dimorphism in Anthonomus santacruzi (Coleoptera: Curculionidae): a Biological Control Agent of Solanum mauritianum Scopoli (Solanaceae)
Authors: Sasa Archbold , Gosik Rafał , Witkowski Ed T. F. , Byrne Marcus J. , Mazur Miłosz A. 
Published: July 2020

AbstractThere is evident variation in body size amongst Anthonomus santacruzi Hustache, 1924, weevils. The aims of this study were to assess if the variation in body size in A. santacruzi weevils is a result of sexual dimorphism and what features can be used to distinguish males from females. The weevils were collected from field sites in Mpumalanga, South Africa, where they were introduced as biocontrol agents of Solanum mauritianum Scopoli. Body structures and the presence/absence of the tergal notch was examined under an optical stereomicroscope and SEM to assess differences between sexes. The morphometric analysis of the body structures included rostrum length (base–apex and antennal insertion–apex), elytral length and width, pronotum length and width, first tarsus length, first tibia length, funiculus length and total body length. Rostrum length, elytra length and width and total body length were significantly larger in females than in males. A tergal notch in the 8th abdominal tergite was present in males and absent in females. The body structure; of rostrum length, elytra length and width and total body length overlapped between sexes in some specimens. The abdominal tergal notch was found to be the most useful body structure to distinguish males from females in A. santacruzi.
Considering the Use of the Term ‘Rehab Potential’ within in-patient Mental Health Services: Its Usefulness and the Risks Associated with Getting it Wrong—A Theoretical Perspective
Authors: Edge Christopher Neil , Tilston-Roberts Neil 
Published: July 2020

Abstract‘Rehab potential’ is a term that is frequently used within in-patient mental health services as means of predicting one’s potential response to rehabilitation-focused interventions. However, there is no explicit and common understanding of the factors that contribute to concept of rehabilitation potential within the context of mental health rehabilitation, despite this being such a commonly used phrase. When accurate predictions are made about a person’s perceived rehabilitation potential, it has the power to enhance a person’s rehabilitation process. If these predictions are inaccurate, they can have negative consequences for the individuals involved. Consequences of inaccurately predicting an individual’s rehabilitation potential can include people being denied access to rehabilitation services or being confined to years of care and/or more restrictive services that may not promote independence or recovery from mental illness as effectively as rehabilitation-focused services. This can have significant implications for these individuals such as reduced feelings of well-being and quality of life. In other medical fields there is evidence that judgments of rehabilitation potential can also have negative implications for the members of staff expected to make these decisions on behalf of service users.