bluuebunny/crossref_metadata_2025_split huggingface dataset:
Profile of Suspended Sediment Concentration in Submerged Vegetated Shallow Water Flow
Authors: Li Y. , Xie L. , Su T. C. 
Published: March 2020

AbstractThe vertical distribution pattern of the fine suspended sediment concentration (SSC) plays an important role in the aquatic ecosystem of shallow water. To investigate the SSC profile in submerged vegetated river flow, a series of indoor flume experiments was conducted. Glass spherical balls of three different diameters (40, 77, and 90 μm) with a uniform specific gravity of 2.5 were used for the model sediments. A set of sampling devices was designed for the simultaneous measurements of SSCs at multipoints along a vertical line. Experimental results show that the SSC profile was re‐distributed in the vegetated region, gradually forming a new equilibrium pattern in the overcanopy flow layer with its maximum occurring near the canopy top. From this maximum point near the canopy top, the suspended sediment formed a dynamic balance between upward turbulent diffusion and downward gravitational settling. Meanwhile, the momentum diffusivity was observed to linearly decrease upward from the maximum‐SSC elevation toward the water surface, thereby allowing us to deduce an empirical negative linear formula. Based on the convection‐diffusion equilibrium mechanism and with assistance of the empirical formula of flow momentum diffusivity, a new form of the Rouse formula was derived for the overcanopy flow layer. In general, this equation agrees well with the measured data. Some undercalculated deviations appear in the well‐above canopy zone due to the upskewed turbulence and the weak upward secondary flow. This deviation decreases with increasing sediment diameter. The bed deposition mainly comes from the deep part of canopy‐occupied flow layer.
Hydrologically Informed Machine Learning for Rainfall‐Runoff Modeling: A Genetic Programming‐Based Toolkit for Automatic Model Induction
Authors: Chadalawada Jayashree , Herath H. M. V. V. , Babovic Vladan 
Published: March 2020

AbstractModels of water resources systems are conceived to capture the underlying environmental dynamics occurring within watersheds. All such models can be regarded as working hypotheses, differing in the aspects of process representation and conceptualization. Most of the associated efforts in the water resources research community is dedicated to development of new models that perform well under specific atmospheric conditions and catchment properties. In this context, flexible modeling frameworks are gaining importance as they facilitate the model building process by providing the model building blocks, whereby the hydrologist is free to assemble the model for task at hand. Such flexible models have high degree of transferability, which in turn aid in progressing toward a unified hydrological theory at catchment scale. However, in cases without sufficient insights regarding a catchment characteristics and/or lack of expert's knowledge, one may have to try a large number of model configurations based on available model building blocks to construct an appropriate model for the catchment of interest. Undoubtedly, this may be time consuming and computationally intensive. This paper proposes a novel model building algorithm, which uses the full potential of flexible modeling frameworks by searching the model space and inferring suitable model configurations relying on machine learning. Proposed machine learning algorithm is based on evolutionary computation approach using genetic programming (GP). State‐of‐art GP applications in rainfall‐runoff modeling so far used the algorithm as a short‐term forecasting tool that generates an expected future time series very similar to neural networks application. In this case, the proposed algorithm develops a physically meaningful rainfall‐runoff model. Although at the moment we learn models using two flexible modeling frameworks (SUPERFLEX and FUSE), the model induction toolkit can be armed with any internal coherence building blocks. The model induction capabilities of the proposed framework have been evaluated on the Blackwater River basin, Alabama, United States. The model configurations evolved through the model induction toolkit are consistent with the fieldwork investigations and previously reported research findings.
O-FIB: far-field-induced near-field breakdown for direct nanowriting in an atmospheric environment
Authors: Li Zhen-Ze , Wang Lei , Fan Hua , Yu Yan-Hao , Chen Qi-Dai , Juodkazis Saulius , Sun Hong-Bo 
Published: March 2020

AbstractNanoscale surface texturing, drilling, cutting, and spatial sculpturing, which are essential for applications, including thin-film solar cells, photonic chips, antireflection, wettability, and friction drag reduction, require not only high accuracy in material processing, but also the capability of manufacturing in an atmospheric environment. Widely used focused ion beam (FIB) technology offers nanoscale precision, but is limited by the vacuum-working conditions; therefore, it is not applicable to industrial-scale samples such as ship hulls or biomaterials, e.g., cells and tissues. Here, we report an optical far-field-induced near-field breakdown (O-FIB) approach as an optical version of the conventional FIB technique, which allows direct nanowriting in air. The writing is initiated from nanoholes created by femtosecond-laser-induced multiphoton absorption, and its cutting “knife edge” is sharpened by the far-field-regulated enhancement of the optical near field. A spatial resolution of less than 20 nm (λ/40, with λ being the light wavelength) is readily achieved. O-FIB is empowered by the utilization of simple polarization control of the incident light to steer the nanogroove writing along the designed pattern. The universality of near-field enhancement and localization makes O-FIB applicable to various materials, and enables a large-area printing mode that is superior to conventional FIB processing.
Programmed cell death 4 as an endogenous suppressor of BDNF translation is involved in stress-induced depression
Authors: Li Yuan , Jia Yufeng , Wang Dongdong , Zhuang Xiao , Li Yan , Guo Chun , Chu Hongxia , Zhu Faliang , Wang Jianing , Wang Xiaoyan , Wang Qun , Zhao Wei , Shi Yongyu , Chen Wanjun , Zhang Lining 
Published: March 2020

AbstractBrain-derived neurotrophic factor (BDNF) is a growth factor that plays vital roles in the neuron survival, growth, and neuroplasticity. Alteration to BDNF expression is associated with major depressive disorder. However, the BDNF translational machinery in depression remains unknown. Herein, we pointed that Pdcd4, a suppressor oncogene, acted as an endogenous inhibitor for the translation of BDNF, and selectively repressed the translation of BDNF splice variant IIc mRNA in an eIF4A-dependent manner. Chronic restraint stress (CRS) up-regulated Pdcd4 expression in hippocampus via decreasing mTORC1-mediated proteasomes degradation pathway, which resulted in the reduction of BDNF protein expression. Moreover, over-expression of Pdcd4 in the hippocampus triggered spontaneous depression-like behaviors under the non-stressed conditions in mice, while systemic or neuron-specific knockout of Pdcd4 reverses CRS-induced depression-like behaviors. Importantly, administration of Pdcd4 siRNA or an interfering peptide that interrupts the Pdcd4-eIF4A complex substantially promoted BDNF expression and rescued the behavioral disorders which were caused by CRS. Overall, we have discovered a previously unrecognized role of Pdcd4 in controlling BDNF mRNA translation, and provided a new method that boosting BDNF expression through blocking the function of Pdcd4 in depression, indicating that Pdcd4 might be a new potential target for depressive disorder therapy.
Elevated serum chemokine CCL22 levels in first-episode psychosis: associations with symptoms, peripheral immune state and in vivo brain glial cell function
Authors: Laurikainen Heikki , Vuorela Arja , Toivonen Anna , Reinert-Hartwall Linnea , Trontti Kalevi , Lindgren Maija , Keinänen Jaakko , Mäntylä Teemu , Paju Janina , Ilonen Tuula , Armio Reetta-Liina , Walta Maija , Tuisku Jouni , Helin Semi , Marjamäki Päivi , Hovatta Iiris , Therman Sebastian , Vaarala Outi , Linnaranta Outi , Kieseppä Tuula , Salokangas Raimo K. R. , Honkanen Jarno , Hietala Jarmo , Suvisaari Jaana 
Published: March 2020

AbstractSeveral lines of research support immune system dysregulation in psychotic disorders. However, it remains unclear whether the immunological marker alterations are stable and how they associate with brain glial cell function. This longitudinal study aimed at investigating whether peripheral immune functions are altered in the early phases of psychotic disorders, whether the changes are associated with core symptoms, remission, brain glial cell function, and whether they persist in a one-year follow-up. Two independent cohorts comprising in total of 129 first-episode psychosis (FEP) patients and 130 controls were assessed at baseline and at the one-year follow-up. Serum cyto-/chemokines were measured using a 38-plex Luminex assay. The FEP patients showed a marked increase in chemokine CCL22 levels both at baseline (p < 0.0001; Cohen’s d = 0.70) and at the 12-month follow-up (p = 0.0007) compared to controls. The group difference remained significant (p = 0.0019) after accounting for relevant covariates including BMI, smoking, and antipsychotic medication. Elevated serum CCL22 levels were significantly associated with hallucinations (ρ = 0.20) and disorganization (ρ = 0.23), and with worse verbal performance (ρ = −0.23). Brain glial cell activity was indexed with positron emission tomography and the translocator protein radiotracer [11C]PBR28 in subgroups of 15 healthy controls and 14 FEP patients with serum CCL22/CCL17 measurements. The distribution volume (VT) of [11C]PBR28 was lower in patients compared to controls (p = 0.026; Cohen’s d = 0.94) without regionally specific effects, and was inversely associated with serum CCL22 and CCL17 levels (p = 0.036). Our results do not support the over-active microglia hypothesis of psychosis, but indicate altered CCR4 immune signaling in early psychosis with behavioral correlates possibly mediated through cross-talk between chemokine networks and dysfunctional or a decreased number of glial cells.
Targeting CD133 reverses drug-resistance via the AKT/NF-κB/MDR1 pathway in colorectal cancer
Authors: Yuan Zeting , Liang Xin , Zhan Yueping , Wang Ziyuan , Xu Jian , Qiu Yanyan , Wang Jie , Cao Yijun , Le Van-Minh , Ly Hai-Trieu , Xu Jianhua , Li Wei , Yin Peihao , Xu Ke 
Published: March 2020

Abstract
Background
Recent studies have shown that multidrug resistance may be induced by the high stemness of cancer cells. Following prolonged chemotherapy, MDR protein 1 (MDR1) and CD133 increase in CRC, but the relationship between them is unclear.

Methods
The relationship between MDR and CSC properties in CRC was determined via CCK-8 assay, apoptosis assay, DOX uptake and retention, immunohistochemistry, immunofluorescence and flow cytometry. The correlations between their expression levels were evaluated using Spearman’s rank statistical test and the Mann-Whitney test. Furthermore, the effect of CD133 on the repression of the AKT/NF-κB/MDR1 signalling pathway was investigated in vitro and in vivo.

Results
We found that CD133 increased with the emergence of drug-resistance phenotypes, and the high expression of MDR1/P-gp was consistently accompanied by positive expression of CD133 as demonstrated by the analysis of patient samples. Up- or downregulation of CD133 could regulate MDR via AKT/NF-κB/MDR1 signalling in CRC. A rescue experiment showed that the AKT/NF-κB signalling pathway is the main mechanism by which CD133 regulates MDR1/P-gp expression in CRC.

Conclusions
Taken together, our results suggest that targeting CD133 reverses drug resistance via the AKT/NF-κB/MDR1 pathway and that this pathway might serve as a potential therapeutic target to reverse MDR in CRC.
PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response
Authors: Ye Jie , Huang Anpei , Wang Haitao , Zhang Anni M. Y. , Huang Xiaojun , Lan Qingping , Sato Tomohiko , Goyama Susumu , Kurokawa Mineo , Deng Chuxia , Sander Maike , Schaeffer David F. , Li Wen , Kopp Janel L. , Xie Ruiyu 
Published: March 2020

AbstractPancreatic ductal adenocarcinoma (PDAC) is associated with metaplastic changes in the pancreas but the transcriptional program underlying these changes is incompletely understood. The zinc finger transcription factor, PRDM3, is lowly expressed in normal pancreatic acini and its expression increases during tumorigenesis. Although PRDM3 promotes proliferation and migration of PDAC cell lines, the role of PRDM3 during tumor initiation from pancreatic acinar cells in vivo is unclear. In this study, we showed that high levels of PRDM3 expression in human pancreas was associated with pancreatitis, and well-differentiated but not poorly differentiated carcinoma. We examined PRDM3 function in pancreatic acinar cells during tumor formation and pancreatitis by inactivating Prdm3 using a conditional allele (Ptf1aCreER;Prdm3flox/flox mice) in the context of oncogenic Kras expression and supraphysiological cerulein injections, respectively. In Prdm3-deficient mice, KrasG12D-driven preneoplastic lesions were more abundant and progressed to high-grade precancerous lesions more rapidly. This is consistent with our observations that low levels of PRDM3 in human PDAC was correlated significantly with poorer survival in patient. Moreover, loss of Prdm3 in acinar cells elevated exocrine injury, enhanced immune cell activation and infiltration, and greatly increased acinar-to-ductal cell reprogramming upon cerulein-induced pancreatitis. Whole transcriptome analyses of Prdm3 knockout acini revealed that pathways involved in inflammatory response and Hif-1 signaling were significantly upregulated in Prdm3-depleted acinar cells. Taken together, our results suggest that Prdm3 favors the maintenance of acinar cell homeostasis through modulation of their response to inflammation and oncogenic Kras activation, and thus plays a previously unexpected suppressive role during PDAC initiation.
The Chaotic Terrains of Mercury Reveal a History of Planetary Volatile Retention and Loss in the Innermost Solar System
Authors: Rodriguez J. Alexis P. , Leonard Gregory J. , Kargel Jeffrey S. , Domingue Deborah , Berman Daniel C. , Banks Maria , Zarroca Mario , Linares Rogelio , Marchi Simone , Baker Victor R. , Webster Kevin D. , Sykes Mark 
Published: March 2020

AbstractMercury’s images obtained by the 1974 Mariner 10 flybys show extensive cratered landscapes degraded into vast knob fields, known as chaotic terrain (AKA hilly and lineated terrain). For nearly half a century, it was considered that these terrains formed due to catastrophic quakes and ejecta fallout produced by the antipodal Caloris basin impact. Here, we present the terrains’ first geologic examination based on higher spatial resolution MESSENGER (MErcury Surface Space ENvironment GEochemistry and Ranging) imagery and laser altimeter topography. Our surface age determinations indicate that their development persisted until ~1.8 Ga, or ~2 Gyrs after the Caloris basin formed. Furthermore, we identified multiple chaotic terrains with no antipodal impact basins; hence a new geological explanation is needed. Our examination of the Caloris basin’s antipodal chaotic terrain reveals multi-kilometer surface elevation losses and widespread landform retention, indicating an origin due to major, gradual collapse of a volatile-rich layer. Crater interior plains, possibly lavas, share the chaotic terrains’ age, suggesting a development associated with a geothermal disturbance above intrusive magma bodies, which best explains their regionality and the enormity of the apparent volume losses involved in their development. Furthermore, evidence of localized, surficial collapse, might reflect a complementary, and perhaps longer lasting, devolatilization history by solar heating.
Common variants of fetal and maternal complement genes in preeclampsia: pregnancy specific complotype
Authors: Banadakoppa Manu , Balakrishnan Meena , Yallampalli Chandra 
Published: March 2020

AbstractPreeclampsia (PE) is a pregnancy specific hypertensive disorder. If untreated PE leads to life threatening condition, eclampsia. Systemic complement activation levels are increased during pregnancy compared to non-pregnant women of childbearing age. In PE, systemic complement levels are further increased, and higher complement deposition has been observed on placentas. We hypothesize that combinations of common SNPs in maternal and fetal complement genes constitute pregnancy specific complotypes and predispose women to PE. In this study, we sequenced two maternal (factor H and C3) and one fetal (CD46) complement genes and identified a total of 9 common SNPs. Minor allele frequencies of two fetal CD46 SNPs were significantly higher in PE. Further, complotypes consisting of fetal CD46 variants and maternal CFH/C3 variants were highly prevalent in PE patients compared to normotensive pregnancies. Placental complement deposition and maternal alternative pathway 50 (AP50) values were higher in PE pregnancies. Irrespective of disease status, two CD46 variants were associated with reduced placental CD46 expression and one CFH variant was associated with increased maternal AP50 values.
A new risk score to assess atrial fibrillation risk in hypertensive patients (ESCARVAL-RISK Project
Authors: Orozco-Beltran Domingo , Quesada Jose A. , Bertomeu-Gonzalez Vicente , Lobos-Bejarano Jose M. , Navarro-Perez Jorge , Gil-Guillen Vicente F. , Garcia Ortiz Luis , Lopez-Pineda Adriana , Castellanos-Rodriguez Angel , Lopez-Domenech Angela , Cardona-Llorens Antonio Francisco J. , Carratala-Munuera Concepcion 
Published: March 2020

AbstractThis study aimed to assess atrial fibrillation (AF) incidence and predictive factors in hypertensive patients and to formulate an AF risk assessment score that can be used to identify the patients most likely to develop AF. This was a cohort study of patients recruited in primary healthcare centers. Patients aged 40 years or older with hypertension, free of AF and with no previous cardiovascular events were included. Patients attended annual visits according to clinical practice until the end of study or onset of AF. The association between AF incidence and explanatory variables (age, sex, body mass index, medical history and other) was analyzed. Finally, 12,206 patients were included (52.6% men, and mean age was 64.9 years); the mean follow-up was 36.7 months, and 394 (3.2%) patients were diagnosed with AF. The incidence of AF was 10.5/1000 person-years. Age (hazard ratio [HR] 1.06 per year; 95% confidence interval [CI] 1.05–1.08), male sex (HR 1.88; 95% CI 1.53–2.31), obesity (HR 2.57; 95% CI 1.70–3.90), and heart failure (HR 2.44; 95% CI 1.45–4.11) were independent predictors (p < 0.001). We propose a risk score based on significant predictors, which enables the identification of people with hypertension who are at the greatest risk of AF.
Internal crack characteristics in very-high-cycle fatigue of a gradient structured titanium alloy
Authors: Pan Xiangnan , Qian Guian , Wu Shengchuan , Fu Yanan , Hong Youshi 
Published: March 2020

AbstractGradient structure (GS) is commonly designed and processed in engineering materials to improve mechanical properties especially fatigue performance by taking advantage of the strengthened surface. However, whether the very-high-cycle fatigue (VHCF) property can be improved by GS is questioning due to the different crack initiation mechanisms between low-, high-cycle and VHCF. In this paper, GS of a Ti-6Al-4V alloy is generated by pre-torsion and characterized by electron backscatter diffraction. Then the VHCF behavior of the GS specimen is studied. The fractography and synchrotron radiation X-ray microtomography presented detailed characteristics of the internal crack initiation region in VHCF of the titanium alloy with GS. The results indicated that, in contrast to the low- and high-cycle regimes, the VHCF strength is reduced for the specimens with GS. Thus, the GS induced by pre-torsion cannot enhance the VHCF strength of the titanium alloy. This implies that VHCF test (property) is an important consideration for the microstructural designed materials. The graphical abstract is available in Supplementary information.
Photonic Crystal Circular Nanobeam Cavity Laser with Type-II GaSb/GaAs Quantum Rings as Gain Material
Authors: Lin Hsiang-Ting , Hsu Kung-Shu , Chang Chih-Chi , Lin Wei-Hsun , Lin Shih-Yen , Chang Shu-Wei , Chang Yia-Chung , Shih Min-Hsiung 
Published: March 2020

AbstractThe optical emission from type-II semiconductor nanostructures is influenced by the long carrier lifetime and can exhibit remarkable thermal stability. In this study, utilizing a high quality photonic crystal circular nanobeam cavity with a high quality factor and a sub-micrometer mode volume, we demonstrated an ultra-compact semiconductor laser with type-II gallium antimonide/gallium arsenide quantum rings (GaSb/GaAs QRs) as the gain medium. The lasing mode localized around the defect region of the nanobeam had a small modal volume and significant coupling with the photons emitted by QRs. It leads the remarkable shortening of carrier lifetime observed from the time-resolved photoluminescence (TRPL) and a high Purcell factor. Furthermore, a high characteristic temperature of 114 K was observed from the device. The lasing performances indicated the type-II QRs laser is suitable for applications of photonic integrated circuit and bio-detection applications.
Microbial community structure and functional properties in permanently and seasonally flooded areas in Poyang Lake
Authors: Liu Yang , Ren Ze , Qu Xiaodong , Zhang Min , Yu Yang , Zhang Yuhang , Peng Wenqi 
Published: March 2020

AbstractWater level fluctuations are an inherent feature regulating the ecological structures and functions of lakes. It is vital to understand the effects of water level fluctuations on bacterial communities and metabolic characteristics in freshwater lakes in a changing world. However, information on the microbial community structure and functional properties in permanently and seasonally flooded areas are lacking. Poyang Lake is a typical seasonal lake linked to the Yangtze River and is significantly affected by water level fluctuations. Bottom water was collected from 12 sampling sites: seven inundated for the whole year (inundated areas) and five drained during the dry season (emerged areas). High-throughput 16S rRNA gene sequencing was used to identify the bacterial communities. The results showed that the taxonomic structure and potential functions of the bacterial communities were significantly different between the inundated and emerged areas. Cyanobacteria was dominant in both areas, but the relative abundance of Cyanobacteria was much higher in the emerged areas than in the inundated areas. Bacterial communities were taxonomically sensitive in the inundated areas and functionally sensitive in the emerged areas. Nitrogen, phosphorus, and dissolved organic carbon concentrations and their ratios, as well as dissolved oxygen, played important roles in promoting the bacterial taxonomic and functional compositional patterns in both areas. According to the metabolic predictions based on 16S rRNA gene sequences, the relative abundance of functional genes related to assimilatory nitrate reduction in the emerged areas was higher than in the inundated areas, and the relative abundance of functional genes related to dissimilatory nitrate reduction in the inundated areas was higher. These differences might have been caused by the nitrogen differences between the permanently and seasonally flooded areas caused by intra-annual water level fluctuations. The relative abundance of functional genes associated with denitrification was not significantly different in the inundated and emerged areas. This study improved our knowledge of bacterial community structure and nitrogen metabolic processes in permanently and seasonally flooded areas caused by water level fluctuations in a seasonal lake.