bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation and characterization of ferrous oxalate cement—A novel acid‐base cement
Authors: Luo Zhongqiu , Ma Yue , He Huan , Mu Weihong , Zhou Xintao , Liao Wenyu , Ma Hongyan 
Published: October 2020

AbstractFerrous oxalate cement (FOC), a new type of acid‐base cement, is prepared at room temperature through reactions between iron‐rich copper slag (CS) and oxalic acid (OA). In this work, the influences of precursor proportions, including the copper slag‐to‐oxalic acid mass ratio (CS/OA), borax‐to‐cement mass ratio (B/C), and water‐to‐cement mass ratio (W/C), on the setting behavior and compressive strength of FOC paste are investigated. Furthermore, the evolutions of pH and ions concentrations are traced to understand the reaction mechanism of FOC. The results show that the compressive strength decreases with an increase in W/C; when W/C is fixed, with an increase in CS/OA, the compressive strength first increases and then decreases, giving an optimal value. The compressive strengths of specimens at 3, 7, and 28 days can reach 33, 41, and 55 MPa, respectively, under the optimal conditions (CS/OA = 3.6, B/C = 0.03, and W/C = 0.18). The setting time is also a function of W/C and CS/OA, and can be extended by adding borax. Iron oxalate hydrate (FeC2O4·2H2O) has been identified as the exclusive hydration product of FOC due to the chemical reaction between Fe2SiO4 or Fe3O4 contained in CS and OA solution. At the initial stage of reaction, OA is dissolved to release protons, HC2O4− and C2O42−, which facilitate the dissolution of Fe2SiO4 and Fe3O4 and the release of Fe2+ in the aqueous phase. Then the Fe2+ ions combine with HC2O4− and C2O42− to precipitate FeC2O4·2H2O, acting as the cementitious phase to bond the unreacted CS particles.
The effects of music ıntervention on breast milk production in breastfeeding mothers: A systematic review and meta‐analysis of randomized controlled trials
Authors: Düzgün Mustafa Volkan , Özer Zeynep 
Published: October 2020

AbstractAimsThe aim of this study was to investigate the effect of music intervention on breast milk production in breastfeeding mothers.DesignA systematic review and meta‐analysis of randomized controlled trials following Cochrane methods were conducted.Data SourcesWe performed a literature search in Web of Science, Science Direct, PubMed, MEDLINE, Cochrane Library, CINAHL, the Networked Digital Library of Theses & Dissertations, Ovid and ProQuest without year limitation. The review period covered January 1978–March 2020.Review MethodsTwo independent researchers screened the literature using specific keywords and selected randomized controlled trials based on the inclusion and exclusion criteria according to the PICOS criteria.ResultOf 2,081 randomized controlled trials, 5 were included in this systematic review and meta‐analysis. The total sample of the five trials was 554 participants. Active and passive music lasting 11–60 min was played in 1–14 sessions. No publication bias was noted. Cochran's Q test results pointed to a low level of heterogeneity among the randomized controlled trials. Overall, the results showed that music intervention had a low and positive effect on breast milk production in breastfeeding mothers.ConclusionA systematic review and meta‐analysis conducted on five trials showed that music can be an effective way to increase breast milk production.ImpactThis systematic review and meta‐analysis investigated the effect of music on breast milk production in breastfeeding mothers and found sound evidence supporting its positive effects. Nurses, academics, mothers, and their children and society can benefit from these results. Nurses who give counselling to breastfeeding mothers can use music intervention to help them increase breast milk production.
Performance of a deep neural network in teledermatology: a single‐centre prospective diagnostic study
Authors: Muñoz‐López C. , Ramírez‐Cornejo C. , Marchetti M.A. , Han S. S. , Del Barrio‐Díaz P. , Jaque A. , Uribe P. , Majerson D. , Curi M. , Del Puerto C. , Reyes‐Baraona F. , Meza‐Romero R. , Parra‐Cares J. , Araneda‐Ortega P. , Guzmán M. , Millán‐Apablaza R. , Nuñez‐Mora M. , Liopyris K. , Vera‐Kellet C. , Navarrete‐Dechent C. 
Published: October 2020

AbstractBackgroundThe use of artificial intelligence (AI) algorithms for the diagnosis of skin diseases has shown promise in experimental settings but has not been yet tested in real‐life conditions.ObjectiveTo assess the diagnostic performance and potential clinical utility of a 174‐multiclass AI algorithm in a real‐life telemedicine setting.MethodsProspective, diagnostic accuracy study including consecutive patients who submitted images for teledermatology evaluation. The treating dermatologist chose a single image to upload to a web application during teleconsultation. A follow‐up reader study including nine healthcare providers (3 dermatologists, 3 dermatology residents and 3 general practitioners) was performed.ResultsA total of 340 cases from 281 patients met study inclusion criteria. The mean (SD) age of patients was 33.7 (17.5) years; 63% (n = 177) were female. Exposure to the AI algorithm results was considered useful in 11.8% of visits (n = 40) and the teledermatologist correctly modified the real‐time diagnosis in 0.6% (n = 2) of cases. The overall top‐1 accuracy of the algorithm (41.2%) was lower than that of the dermatologists (60.1%), residents (57.8%) and general practitioners (49.3%) (all comparisonsP < 0.05, in the reader study). When the analysis was limited to the diagnoses on which the algorithm had been explicitly trained, the balanced top‐1 accuracy of the algorithm (47.6%) was comparable to the dermatologists (49.7%) and residents (47.7%) but superior to the general practitioners (39.7%;P = 0.049). Algorithm performance was associated with patient skin type and image quality.ConclusionsA 174‐disease class AI algorithm appears to be a promising tool in the triage and evaluation of lesions with patient‐taken photographs via telemedicine.
A new species of Characidium (Characiformes: Crenuchidae) from the rio Madeira basin, Brazil
Authors: Zanata Angela M. , Ohara Willian M. 
Published: October 2020

AbstractThis study describes Characidium nambiquara, a new species from the upper rio Guaporé, rio Madeira basin, Brazil. The new species differs from most congeners by the presence of isthmus and area between the contralateral pectoral‐fin bases completely naked. From congeners with some degree of scaleless ventral surface of the body C. nambiquara differs by having 10 circumpeduncular scales. The new species is also distinguished from congeners by the spotted colour pattern on body of the large‐sized specimens and by having black dashes on all fins and conspicuous midlateral longitudinal dark stripe or conspicuous vertical bars absent. Characidium nambiquara further differs from most congeners by the presence of 34–36 pored scales on the lateral line, 3 horizontal scale rows above the lateral line and 3 horizontal scale rows from the lateral line to the midventral scale series. Remarks on intraspecific colour variation within the genus, not related to sexual dimorphism, are also provided.
Rifabutin triple therapy for first‐line and rescue treatment of Helicobacter pylori infection: A systematic review and meta‐analysis
Authors: Gingold‐Belfer Rachel , Niv Yaron , Levi Zohar , Boltin Doron 
Published: October 2020

AbstractBackground and AimDue to the increasing resistance of Helicobacter pylori, there is a need for novel antibiotic treatment protocols. We aimed to perform a systematic review and meta‐analysis in order to determine the effectiveness and safety of rifabutin triple therapy for H. pylori infection.MethodsWe performed a systematic review of prospective clinical trials with a treatment arm consisting of proton pump inhibitor, amoxicillin, and rifabutin and a meta‐analysis of randomized controlled trials (RCTs).ResultsThirty‐three prospective studies including 44 datasets were identified. Meta‐analysis of four RCTs for rescue treatment found no difference between treatment groups (odds ratio [OR] 0.88, 95% confidence interval [CI] 0.437–1.791, I2 = 68.1%, P = 0.733). Only one RCT compared rifabutin therapy with control for first‐line treatment of H. pylori infection (OR 3.78, 95% CI 2.44–5.87, P < 0.0001). Treatment was more likely to be successful in Asian versus non‐Asian populations (81.0% vs 72.4%, P = 0.001) and when daily amoxicillin dose was ≥ 3000 mg or proton pump inhibitor dose was ≥ 80 mg or treatment duration was 14 days (80.6% vs 66.0%, P = 0.0001). The overall event rate for adverse effects was 24.8% (729/2937) (95% CI 0.23–0.26), and the pooled OR for adverse effects in the treatment versus control group was 0.93 (95% CI 0.50–1.75) (I2 = 79.76, P = 0.82).ConclusionEvidence for the effectiveness of rifabutin for the first‐line treatment of H. pylori infection in adults is limited, and studies comparing rifabutin with conventional first‐line treatments are lacking.
Ppp1r3d deficiency preferentially inhibits neuronal and cardiac Lafora body formation in a mouse model of the fatal epilepsy Lafora disease
Authors: Israelian Lori , Nitschke Silvia , Wang Peixiang , Zhao Xiaochu , Perri Ami M. , Lee Jennifer P.Y. , Verhalen Brandy , Nitschke Felix , Minassian Berge A. 
Published: October 2020

AbstractMammalian glycogen chain lengths are subject to complex regulation, including by seven proteins (protein phosphatase‐1 regulatory subunit 3, PPP1R3A through PPP1R3G) that target protein phosphatase‐1 (PP1) to glycogen to activate the glycogen chain‐elongating enzyme glycogen synthase and inactivate the chain‐shortening glycogen phosphorylase. Lafora disease is a fatal neurodegenerative epilepsy caused by aggregates of long‐chained, and as a result insoluble, glycogen, termed Lafora bodies (LBs). We previously eliminated PPP1R3C from a Lafora disease mouse model and studied the effect on LB formation. In the present work, we eliminate and study the effect of absent PPP1R3D. In the interim, brain cell type levels of all PPP1R3 genes have been published, and brain cell type localization of LBs clarified. Integrating these data we find that PPP1R3C is the major isoform in most tissues including brain. In the brain, PPP1R3C is expressed at 15‐fold higher levels than PPP1R3D in astrocytes, the cell type where most LBs form. PPP1R3C deficiency eliminates ~90% of brain LBs. PPP1R3D is quantitatively a minor isoform, but possesses unique MAPK, CaMK2 and 14‐3‐3 binding domains and appears to have an important functional niche in murine neurons and cardiomyocytes. In neurons, it is expressed equally to PPP1R3C, and its deficiency eliminates ~50% of neuronal LBs. In heart, it is expressed at 25% of PPP1R3C where its deficiency eliminates ~90% of LBs. This work studies the role of a second (PPP1R3D) of seven PP1 subunits that regulate the structure of glycogen, toward better understanding of brain glycogen metabolism generally, and in Lafora disease.
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SynaptoPAC, an optogenetic tool for induction of presynaptic plasticity
Authors: Oldani Silvia , Moreno‐Velasquez Laura , Faiss Lukas , Stumpf Alexander , Rosenmund Christian , Schmitz Dietmar , Rost Benjamin R. 
Published: October 2020

AbstractOptogenetic manipulations have transformed neuroscience in recent years. While sophisticated tools now exist for controlling the firing patterns of neurons, it remains challenging to optogenetically define the plasticity state of individual synapses. A variety of synapses in the mammalian brain express presynaptic long‐term potentiation (LTP) upon elevation of presynaptic cyclic adenosine monophosphate (cAMP), but the molecular expression mechanisms as well as the impact of presynaptic LTP on network activity and behavior are not fully understood. In order to establish optogenetic control of presynaptic cAMP levels and thereby presynaptic potentiation, we developed synaptoPAC, a presynaptically targeted version of the photoactivated adenylyl cyclase bPAC. In cultures of hippocampal granule cells of Wistar rats, activation of synaptoPAC with blue light increased action potential‐evoked transmission, an effect not seen in hippocampal cultures of non‐granule cells. In acute brain slices of C57BL/6N mice, synaptoPAC activation immediately triggered a strong presynaptic potentiation at mossy fiber synapses in CA3, but not at Schaffer collateral synapses in CA1. Following light‐triggered potentiation, mossy fiber transmission decreased within 20 min, but remained enhanced still after 30 min. The optogenetic potentiation altered the short‐term plasticity dynamics of release, reminiscent of presynaptic LTP. Our work establishes synaptoPAC as an optogenetic tool that enables acute light‐controlled potentiation of transmitter release at specific synapses in the brain, facilitating studies of the role of presynaptic potentiation in network function and animal behavior in an unprecedented manner.
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Effect of one session of aerobic exercise associated with abdominal laser therapy in lipolytic activity, lipid profile, and inflammatory markers
Authors: Barbosa Patrícia , Coimbra Catarina , Noites Andreia , Vilarinho Rui , Carvalho Paulo , Amorim Manuela , Moreira Teresa , Melo Cristina 
Published: October 2020

AbstractBackgroundIncreased abdominal fat and sedentary lifestyles contribute to cardiovascular disease risk. The combination of exercise and low‐level laser therapy (LLLT) appears to be an innovative method to increase the lipolytic rate of abdominal adipocytes, in order to reduce abdominal fat.ObjectivesTo evaluate the effect of one session of aerobic exercise associated with abdominal laser therapy in lipolytic activity, profile lipid, and inflammatory markers (C‐reactive protein—CRP).MethodsExperimental randomized controlled study in 36 participants of female sex divided into three groups: placebo group (PG) (n = 12), experimental group 1 (EG1) (n = 11), and experimental group 2 (EG2) (n = 13). The EG1 and EG2 performed the laser therapy protocol followed by 50 minutes of aerobic exercise on cycle ergometer, of 45%‐55% of reserve heart rate; however, in EG2 the laser therapy was applied without power. The PG only performed the laser therapy protocol without power. The anthropometric measures were evaluated, and all participants were subject to blood samples at the beginning and at the end of the intervention for measure glycerol, lipid profile (total cholesterol, triglycerides, HDL, and LDL), and CRP. One‐way ANOVA was used to compare the groups in the quantitative variables and Fisher's test to compare the groups in the qualitative variables. To compare the variables between moments (M0 and M1), we used thettest for paired samples.ResultsIn the group that performed physical exercise and lipolytic laser and in the group that performs only physical exercise, there was a significant increase in glycerol mobilization between M0 and M1 (P < .001). The same did not occur in the placebo group. Regarding the CRP levels and lipidic profile, no significant differences were observed between moments in the experimental groups.ConclusionIt is concluded that one session of aerobic exercise associated with LLLT and one session of aerobic exercise appears to be able to increase the lipolytic activity. However, it appears that LLLT does not provide increased value to the aerobic physical exercise by itself in lipolysis process.
Growth, behavioural, serum biochemical and morphological changes in female rabbits fed high‐fat diet
Authors: Shao Jiahao , Wang Jie , Li Yanhong , Elzo Mauricio A. , Tang Tao , Lai Tianfu , Ma Yuan , Gan Mingchuan , Wang Li , Jia Xianbo , Lai Songjia 
Published: October 2020

AbstractThis study aimed to determine whether high‐fat diet (HFD) could cause growth, behavioural, biochemical and morphological changes in young female rabbits. Thirty‐six female rabbits were randomly divided into two groups fed with either a high‐fat diet (HFD) or a standard normal diet (SND) for 5 weeks. Growth and behavioural changes were recorded during the 5‐week feeding period. Tissue samples, including blood and adipose tissue, were obtained after slaughter. HFD rabbits weighed more by the end of the feeding period, had a higher percent body weight and adipose tissue weight change and had longer body and bust lengths than SND rabbits. HFD rabbits significantly reduced their feed intake and feeding frequency during the fourth and fifth weeks. HFD rabbits also showed lower frequency of drinking and resting and increased stereotypical behaviour. Besides, HFD rabbits showed significant physiological abnormalities. HFD rabbits had higher serum cholesterol (TC) and triglycerides (TG) levels than SND rabbits at the end of the feeding period, and higher free fatty acid (FFA) levels than rabbits in the SND group after the third week of feeding. Serum thyroxine (T4) increased significantly in week 2 and week 5 and triiodothyronine (T3) increased significantly in week four. However, there was no significant change in serum glucose (GLU) and insulin (INS) levels. Additionally, HFD reduced the area and diameter of perirenal and subcutaneous fat cells and increased their density. Our findings suggest that HFD rabbits had higher weight gains, accumulation of fat, and more behavioural changes than SND rabbits. Although high levels of fat in the diet had a low impact on hyperglycaemia, it could lead to hyperlipidemia and hyperthyroidism. Our results also suggest that sustained HFD may cause the proliferation of adipocytes in young female rabbits.
Temporal association between objectively measured smartphone usage, sleep quality and physical activity among Chinese adolescents and young adults
Authors: Lee Paul H. , Tse Andy C. Y. , Wu Cynthia S. T. , Mak Yim Wah , Lee Uichin 
Published: October 2020

AbstractWe studied the association between objectively measured smartphone usage and objectively measured sleep quality and physical activity for seven consecutive days among Hong Kong adolescents and young adults aged 11–25 years (n = 357, 67% female). We installed an app that tracked the subjects’ smartphone usage and had them wear an ActiGraph GT3X accelerometer on their wrist to measure their sleep quality and physical activity level. Smartphone usage data were successfully obtained from 187 participants (52.4%). The participants on average spent 2 h 46 min per day on their smartphone. Multilevel regression showed that 1 min of daytime smartphone usage was associated with 0.07 min decrease in total sleeping time that night (p = .043, 95% confidence interval [CI]: −0.14, −0.003). Broken down for different usage purposes, 1 min of daytime social network usage and games and comics was associated with a 0.28 (p = .02, 95% CI: −0.52, −0.04) min and 0.18 min (p = .01, 95% CI: −0.32, −0.04) decrease in total sleeping time that night, respectively. One minute of daytime smartphone usage was associated with an increase of 4.55 steps in the number of steps (p = .001, 95% CI: 1.77, 7.34) on the next day. To conclude, time spent on a smartphone in the daytime was associated with total sleeping time that night and number of steps the next day, but was not associated with sleep efficiency, wake after sleep onset and moderate‐to‐vigorous‐intensity activity (MVPA) among Hong Kong adolescents and young adults.
Grazing and microhabitat interact to affect plant–plant interactions in subtropical seasonal wetlands
Authors: Boughton Elizabeth H. , Quintana‐Ascencio Pedro F. , Bohlen Patrick J. 
Published: October 2020

AbstractAimsThe stress gradient hypothesis predicts that competition will be important in productive environments while facilitation will be common in environments with high stress or consumer pressure. However, abiotic stress and grazing may vary independently and even occur simultaneously. Here we examine the outcome of plant interactions in grazed wetlands where consumer pressure and abiotic stress occur concurrently. We hypothesized that cattle grazing and microhabitat would alter the outcome of plant interactions. Given that wetland edges are drier and less productive than wetland centers we expected that facilitation would be greatest in drier wetland edges due to greater abiotic stress regardless of cattle presence.LocationArchbold Biological Station's Buck Island Ranch (BIR), south‐central Florida, USA (27°09′ N, 81°11′ W).MethodsWe conducted an experiment for two growing seasons in ten wetlands, five exposed to cattle grazing and five fenced. Two wetland obligate plants were included (Panicum hemitomon and Alternanthera philoxeroides), and plots were assigned to three treatments (a) all neighbors removed; (b) all neighbors removed except Juncus effusus, a dominant, unpalatable plant; and (c) all neighbors intact (control), in both wetland centers and edges. Differences in survival, change in height and number of leaves were assessed.ResultsIn ungrazed wetlands, plant survival was higher in wetland edges vs centers, while it did not differ between microhabitats in grazed wetlands. Survival in wetland edges was further increased by the presence of Juncus effusus. Positive interactions under grazed conditions were clear when plant height was assessed, but negative interactions affected leaf production in both ungrazed and grazed wetlands.ConclusionsGrazing interacts with wetland microhabitat to alter plant survival. Facilitative interactions on plant height were apparent in grazed wetlands. Understanding how plant interactions change under different biotic and abiotic contexts is important for informing ecosystem restoration and management.
Intestinal permeability in human nonalcoholic fatty liver disease: A systematic review and meta‐analysis
Authors: De Munck Toon J. I. , Xu Pan , Verwijs Harm J. A. , Masclee Ad A. M. , Jonkers Daisy , Verbeek Jef , Koek Ger H. 
Published: October 2020

AbstractBackgroundThe gut‐liver axis is considered to play a critical role in the development and progression of nonalcoholic fatty liver disease (NAFLD). The integrity of the epithelial barrier is crucial to protect the liver against the invasion of microbial products from the gut, although its exact role in NAFLD onset and progression is not clear.MethodsWe performed a systematic review and meta‐analysis of studies that addressed the intestinal permeability (IP) in association with NAFLD presence or severity as defined by the presence of nonalcoholic steatohepatitis (NASH) and the degree of steatosis, hepatic inflammation or fibrosis. A total of 14 studies were eligible for inclusion.ResultsStudies investigating IP in adult (n = 6) and paediatric (n = 8) NAFLD showed similar results. Thirteen of the included studies focussed on small IP, two studies on whole gut permeability and none on colonic permeability. In the pooled analysis, NAFLD patients showed an increased small intestinal permeability compared to healthy controls based on dual sugar tests (standardized mean difference 0.79, 95% CI 0.49‐1.08) and serum zonulin levels (standardized mean difference 1.04 ng/mL, 95% CI 0.40‐1.68). No clear difference in IP was observed between simple steatosis and NASH patients. Furthermore, whole gut and small intestinal permeability increased with the degree of hepatic steatosis in 4/4 studies, while no association with hepatic inflammation or fibrosis was observed.ConclusionBased on the limited number of studies available, IP appears to be increased in NAFLD patients compared to healthy controls and is associated with the degree of hepatic steatosis.