bluuebunny/crossref_metadata_2025_split huggingface dataset:
Motor-evoked potentials in amyotrophic lateral sclerosis: potential implications in detecting subclinical UMN involvement in lower motor neuron phenotype
Authors: Zoccolella Stefano , Mastronardi Antonella , Scarafino Antonio , Iliceto Giovanni , D’Errico Eustachio , Fraddosio Angela , Tempesta Irene , Morea Antonella , Scaglione Gaspare , Introna Alessandro , Simone Isabella Laura 
Published: July 2020

Abstract
Background
In amyotrophic lateral sclerosis (ALS), the involvement of lower motor neuron is well defined by electromyography, whereas a reliable marker of upper motor neuron (UMN) damage still lacks. Aim of the study was to estimate the role of transcranial magnetic stimulation (TMS)-induced motor-evoked potentials (MEPs) as marker of subclinical UMN involvement.

Methods
Clinical evidence of UMN damage was prospectively compared to MEPs in 176 ALS patients diagnosed between 2011 and 2014, and classified according to existing diagnostic criteria. Finally, we evaluated the appearance of clinical UMN signs and the level of diagnostic certainty in ALS after 1 year of follow-up.

Results
At presentation, abnormal MEPs were found in 80% of patients with clinical evidence of UMN damage and in 72% of patients without clinical involvement of UMN. Among these latter, 61% showed appearance of UMN clinical signs after 1 year. Approximately 70% of patients with clinical lower motor neuron (LMN) phenotype showed MEP abnormalities, while they were considered not classifiable ALS according to Airlie house or Awaji criteria. Furthermore, abnormal MEPs in absence of clinical UMN signs at baseline were found in 80% of spinal ALS that after 1-year developed UMN signs at limbs, compared to 50% of bulbar ALS.

Conclusions
TMS is a reliable marker of subclinical UMN damage particularly among LMN phenotype and ensure an early ALS diagnosis in ~ 70% of such cases.
Systems analysis for deployment of internet of things (IoT) in the maritime industry
Authors: Hiekata Kazuo , Wanaka Shinnosuke , Mitsuyuki Taiga , Ueno Ryuji , Wada Ryota , Moser Bryan 
Published: July 2020

AbstractVarious industries are undergoing transformation given recently available pervasive sensors, low-cost and low-latency digital communication, and distributed control technologies. The objective of this paper is to support the introduction of Internet of things (IoT) technologies in the maritime industry. The maritime industry is analyzed as a system of systems to define performance criteria and functions to be modeled and analyzed through simulation. In this case, the simulation of a shipping system includes models of operation, cargo loading, fuel loading, and docking for maintenance. In the simulation, various kinds of IoT technologies are defined by several input parameters. By changing the parameters, the simulator evaluates the impact of those technologies quantitatively. As a case study, 11 IoT technologies are evaluated and compared. The result reveals several insights that weight of the ship is the most impactful for the profit, controlling damage of the ship’s hull by operation is the most important for safety, and improvement in efficiency at ports is the key to reducing delay time in operation. Moreover, this paper shows that the sensitivity analysis by changing the input parameters can support the decision making of how much investment will be effective in considering the technologies’ levels.
Post-collection Separation of Plastic Waste: Better for the Environment and Lower Collection Costs?
Authors: Dijkgraaf Elbert , Gradus Raymond 
Published: July 2020

AbstractThe European Union advocates a plastic waste recycling rate of more than 55%. Even for the Netherlands, which has already invested heavily in recycling plastic waste of households, it will still be a challenge to meet this target. The preferred solution to fulfil this target in the Netherlands is implementing separate collection schemes at the curbside, although some municipalities invested in post-separation. We show, based on data for 2013–2014, that post-collection separation is an advisable alternative, with an increased separation of plastic waste compared with home separation. This is even slightly the case if home separation is combined with a unit-based pricing system for unsorted waste and with a frequent door-to-door collection of plastic waste. Moreover, there are indications that the cost effectiveness of recycling plastic waste increases if post separation is chosen. In addition, some claim that unit-based pricing of unsorted waste is important to create an awareness effect to buy less packaging material. However, based on the combination of post separation and unit-based pricing, we have no indication for such awareness effect as the price effect on the amount of plastic waste is insignificantly small.
Implicit Anthropologies in Pre-philosophical Śaivism with Particular Reference to the Netra-tantra
Authors: Flood Gavin 
Published: July 2020

AbstractWhile there are overt philosophies of the person in both dualistic and non-dualistic Śaivism that developed their doctrines explicitly in relation to each other and to non-Śaiva traditions, especially Buddhism, many Śaiva texts exemplify what might be called a pre-philosophical discourse. Such works contain philosophical ideas but do not present systematic arguments (that is the job of later commentators) and are often regarded as divine revelation (namely the tantras but other genres of literature might also be included such as paddhatis). It is this layer of the articulation of concepts linked to practices that the paper exposes, which the arguments of the later philosophers reflect upon and from which they develop. The claim here is that through an analysis of pre-philosophical literature, texts such as the Netra-tantra, we can build a picture of the conceptual universe of the early medieval period that forms the basis for the development of thinking by the later philosophers. One way of doing this is through the micro-study of particular textual passages and from that to build a larger picture of pre-philosophical discourse.
Towards constructive design feedback dialogues: guiding peer and client feedback to stimulate children’s creative thinking
Authors: Schut Alice , van Mechelen Maarten , Klapwijk Remke M. , Gielen Mathieu , de Vries Marc J. 
Published: July 2020

AbstractDesign feedback is an essential pedagogical tool that can help young novice designers navigate divergent and convergent paths while designing. However, design feedback is often met with resistance, which counteracts its potential to help novice designers evaluate their design and generate new solution directions. In this paper, we report on the construction and utilization of a design feedback intervention during a real-life design project with a group of primary school children (aged 8–12). The goal of the intervention was to stimulate young novice designers’ creative thinking by guiding the design feedback dialogues with their peers and clients. The intervention was designed according to the following key principles: (1) guide towards a shared understanding of the design through low-level convergent feedback, (2) stimulate critical reflection and evaluation of the design to help identify and internalize possible shortcomings through high-level convergent feedback, and (3) provide a way to move forward by guiding new generative thoughts through high-level divergent feedback. Overall, the results show that the intervention can support young novice designers, their peers, and clients in engaging in constructive feedback dialogues, thereby stimulating their creative thinking. Our main contribution entails a detailed understanding of the successes and obstacles within the feedback dialogues, as guided by the intervention. Based on these results, we propose a set of refined design principles to inform feedback interventions. With this research we hope to give insight in the complexity of design feedback dialogues, while also inspiring design educators to actively try out these key principles.
The Different Roles of Hedonic and Eudaimonic Motives for Activities in Predicting Functioning and Well-Being Experiences
Authors: Giuntoli Laura , Condini Federica , Ceccarini Francesco , Huta Veronika , Vidotto Giulio 
Published: July 2020

AbstractResearch on hedonic and eudaimonic orientations has previously focused on their effects on well-being experiences. Very little is known about their associations with functioning. A preliminary objective of the study was to establish the factorial validity of the Hedonic and Eudaimonic Motives for Activities–Revised (HEMA-R) on an Italian sample (N = 461) through a confirmatory factor analysis. The main objective was to study the distinctive patterns of correlates between different types of orientations to well-being and several outcome measures of positive experiences (flourishing, life satisfaction, positive affect), negative experiences (negative affect, depression, anxiety, stress) and functioning (dispositional coping strategies) by means of a multivariate linear model. The Italian version of the HEMA-R showed a three-factor structure, namely eudaimonic, pleasure, and relaxation orientations. Pleasure orientation was positively related to positive experiences of well-being and negatively related to negative experiences. Eudaimonic orientation was associated with positive experiences. Furthermore, eudaimonic orientation showed a positive relation with several adaptive coping strategies, whereas relaxation was associated with avoidant coping strategies. The results reflect that pleasure orientation is aimed at achieving pleasant feelings, while Eudaimonic orientation is aimed at living well. Our findings also suggest that pleasure orientation may reflect the “pursuit of pleasure” component of Hedonia, while relaxation orientation may reflect its “pain avoidance” component. Overall, this study supports the importance of distinguishing between Eudaimonia, and the pleasure and relaxation components of Hedonia to predict individual differences in subjective experiences and functioning.
Central limit theorems for nearly long range dependent subordinated linear processes
Authors: Wendler Martin , Wu Wei Biao 
Published: July 2020

AbstractThe limit behavior of partial sums for short range dependent stationary sequences (with summable autocovariances) and for long range dependent sequences (with autocovariances summing up to infinity) differs in various aspects. We prove central limit theorems for partial sums of subordinated linear processes of arbitrary power rank which are at the border of short and long range dependence.
Research tasks on ethics in applied linguistics
Authors: De Costa Peter I. , Sterling Scott , Lee Jongbong , Li Wendy , Rawal Hima 
Published: July 2020

AbstractThe growing concern for ethics in applied linguistics may be attributed to attempts to stem the rising incidence of ethical lapses in order to ensure that the core ethical principles of (1) respect for persons, (2) yielding optimal benefits while minimizing harm, and (3) justice are preserved. Following a brief historical review of this topic, and building on the growing commitment to carry out ethical applied linguistic research, we map out seven research tasks that will enhance our understanding of how to extend this expanding research agenda. By inviting applied linguists to evaluate their methodological practices and those of their peers, we also argue for the need to develop the ethical dispositions of emerging applied linguists, with a view to create a more robust field.
A Quadruped Soft Robot for Climbing Parallel Rods
Authors: Zhu Nana , Zang Hongbin , Liao Bing , Qi Huimin , Yang Zheng , Chen Mingyang , Lang Xin , Wang Yunjie 
Published: July 2020

SUMMARYSoft robots can perform effectively inspecting than rigid robots in some special environments such as nuclear pipelines and high-voltage cables. This article presents a versatile quadruped soft rod-climbing robot (SR-CR) that consists of four bending actuators and a telescopic actuator. The bending actuator is composed of flexible bellows with multiple folding air chambers, elastic telescopic layer (ETL), and strain-limiting layer (SLL). The telescopic actuator provides the energy for the robot to climb forward. The SR-CR is activated by a control strategy that alternates the body deformation and feet pneumatic clenched for stable climbing. The robot can climb rods at 90°, with the maximum speed of up to 2.33 mm/s (0.018 body length/s). At 0.83 HZ, the maximum moving speed of the robot in climbing horizontally parallel rods can reach 18.43 mm/s. In addition, the SR-CR can also achieve multiple impressive functions, including turning around a corner at a rate of 7 mm/s (0.054 body length/s), carrying a payload of 3.7 times its self-weight on horizontal rods at a speed of 9 mm/s (0.069 body length/s).
Investigation into a national outbreak of STEC O157:H7 associated with frozen beef burgers, UK, 2017
Authors: Byrne Lisa , Kaindama Lukeki , Bentley Maria , Jenkins Claire , Aird Heather , Oliver Isabel , Paranthaman Karthik 
Published: July 2020

Abstract
In November 2017, Public Health England identified an outbreak of Shiga toxin-producing Escherichia coli O157:H7 in England where whole genome sequencing results indicated cases were likely to be linked to a common source, and began investigations. Hypothesis generation included a review of enhanced surveillance data, a case-case study and trawling interviews. The hypothesis of interest was tested through the administration of focussed questionnaires and review of shopping history using loyalty card data. Twelve outbreak cases were detected, eight were hospitalised and four developed haemolytic uraemic syndrome. Frozen beef burgers supplied by a national retailer were identified as the vehicle of the outbreak. Testing of two left-over burger samples obtained from the freezers of two separate (unlinked) cases and a retained sample from the production premises were tested and found to be positive for the outbreak strain. A voluntary recall of the burgers was implemented by the retailer. Investigations at the production premises identified no contraventions of food safety legislation. Cooking guidance on the product packaging was deemed to be adequate and interviews with the cases/carers who prepared the burgers revealed no deficiencies in cooking practices at home. Given the long-shelf life of frozen burgers, the product recall likely prevented more cases.
Investigation on knowledge, attitudes and practices about food safety and nutrition in the China during the epidemic of corona virus disease 2019
Authors: Luo Yingyi , Chen Linjun , Xu Fei , Gao Xiaoxia , Han Dan , Na Lixin 
Published: July 2020

AbstractObjective:To investigate the knowledge, attitudes and practices (K-A-P) about food safety and nutrition in Chinese adults who were recruited to the online survey during the epidemic of corona virus disease 2019 (COVID-19).Design:Participants were recruited by an online snowball sampling method. An electronic questionnaire was sent to our colleagues, students, friends, other professionals and their referrals helped us recruit more participants. The questionnaire included socio-demographic information, the attention paid to COVID-19, K-A-P about food safety and nutrition. Multiple and logistic regression analyses were used to explore related factors of K-A-P.Subjects:Totally, 2272 participants aged 24·09 ± 9·14 years, from twenty-seven provinces, autonomous districts or municipalities, with 18·3 % male and 83·4 % with a medical background.Results:The total possible knowledge score was 8·0, the average score was 5·2 ± 1·6 and 4·2 % obtained 8·0. The total possible attitudes score was 8·0, the average score was 6·5 ± 1·4 and 36·1 % obtained 8·0. The total possible food safety practices score was 5·0, the average score was 3·7 ± 1·0 and 20·7 % obtained 5·0. During this public emergency, 79·4 % participants changed diet habits, including increasing vegetables, fruit and water intake and reducing sugary drinks and snacks. Gender, age, educational and professional background, disease history, the attention paid to COVID-19 and related knowledge were associated with K-A-P.Conclusion:There was room for the improvement of K-A-P in participants during this public health emergency and further strengthening education about food safety and nutrition is needed. Findings indicate that education should address biased or misleading information and promote nutritious food choices and safe food practices.
Interhemispheric Comparisons of Large Nighttime Magnetic Perturbation Events Relevant to GICs
Authors: Engebretson Mark J. , Kirkevold Kathryn R. , Steinmetz Erik S. , Pilipenko Viacheslav A. , Moldwin Mark B. , McCuen Brett A. , Clauer C. R. , Hartinger Michael D. , Coyle Shane , Opgenoorth Hermann , Schillings Audrey , Willer Anna N. , Edwards Thom R. , Boteler David H. , Gerrard Andy J. , Freeman Mervyn P. , Rose Michael C. 
Published: July 2020

AbstractNearly all studies of impulsive magnetic perturbation events (MPEs) with large magnetic field variability (dB/dt) that can produce dangerous geomagnetically induced currents (GICs) have used data from the Northern Hemisphere. Here we present details of four large‐amplitude MPE events (|ΔBx| > 900 nT and |dB/dt| > 10 nT/s in at least one component) observed between 2015 and 2018 in conjugate high‐latitude regions (65–80° corrected geomagnetic latitude), using magnetometer data from (1) Pangnirtung and Iqaluit in eastern Arctic Canada and the magnetically conjugate South Pole Station in Antarctica and (2) the Greenland West Coast Chain and two magnetically conjugate chains in Antarctica, AAL‐PIP and BAS LPM. From one to three different isolated MPEs localized in corrected geomagnetic latitude were observed during three premidnight events; many were simultaneous within 3 min in both hemispheres. Their conjugate latitudinal amplitude profiles, however, matched qualitatively at best. During an extended postmidnight interval, which we associate with an interval of omega bands, multiple highly localized MPEs occurred independently in time at each station in both hemispheres. These nighttime MPEs occurred under a wide range of geomagnetic conditions, but common to each was a negative interplanetary magnetic field Bz that exhibited at least a modest increase at or near the time of the event. A comparison of perturbation amplitudes to modeled ionospheric conductances in conjugate hemispheres clearly favored a current generator model over a voltage generator model for three of the four events; neither model provided a good fit for the premidnight event that occurred near vernal equinox.
Analysis of the foveal microvasculature in sickle cell disease using swept-source optical coherence tomography angiography
Authors: Mokrane A. , Gazeau G. , Lévy V. , Fajnkuchen F. , Giocanti-Aurégan Audrey 
Published: July 2020

AbstractIschemic microangiopathy was clearly identified in sickle cell disease (SCD) using fluorescein angiography. A prospective observational clinical study was conducted to assess the foveal avascular zone (FAZ) area and explore perifoveal microvasculature changes in the superficial (SCP) and deep (DCP) capillary plexus using optical coherence tomography angiography (OCTA) and compare two genotypes—HbS/HbS (HbSS) and HbS/HbC (HbSC)-to control. All consecutive patients with electrophoretic confirmation of SCD were included. Swept-source OCTA scans (Triton Plus, Topcon, Tokyo, Japan) with a 3 × 3-mm scanning area and ultra-wide field (UWF) retinography (California, Optos, Fife, Scotland) were recorded for all patients. For OCTA analysis, preset parameters were used to segment the SCP and DCP. The FAZ area was manually assessed. The number of vascular branching points was automatically assessed based on the vascular skeletonization using ImageJ software. Eyes were staged based on Goldberg’s classification of SCD retinopathy (SCDR) using UWF imaging. Forty-six eyes of 24 patients were included in the HbSS (n = 27) and HbSC (n = 19) groups and 16 eyes of 8 unaffected patients in a control group. In the DCP, the FAZ was significantly larger in the HbSC (p = 0.0001) and HbSS (p = 0.0004) groups compared to controls. The FAZ area in the SCP, CRT and number of superficial vascular branching points did not significantly differ between both genotypes. There were less branching points in the HbSC (p = 0.034) and HbSS (p = 0.0014) groups than in controls. The Goldberg stage was significantly higher in the HbSC group than in the HbSS group (2.21 vs. 1.22, p = 0.0062). OCTA provides useful information on macular microvasculature and structural alterations associated with SCDR. Ischemic abnormalities are more predominant in the DCP in case of SCDR and no difference was found between genotypes of patients visually asymptomatic.
Microfibril-associated glycoprotein 4 (Mfap4) regulates haematopoiesis in zebrafish
Authors: Ong Sheena L. M. , de Vos Ivo J. H. M. , Meroshini M. , Poobalan Yogavalli , Dunn N. Ray 
Published: July 2020

AbstractMicrofibril-associated glycoprotein 4 (MFAP4) is an extracellular matrix protein belonging to the fibrinogen-related protein superfamily. MFAP4 is produced by vascular smooth muscle cells and is highly enriched in the blood vessels of the heart and lung, where it is thought to contribute to the structure and function of elastic fibers. Genetic studies in humans have implicated MFAP4 in the pathogenesis of Smith-Magenis syndrome, in which patients present with multiple congenital abnormalities and mental retardation, as well as in the severe cardiac malformation left-sided congenital heart disease. Comprehensive genetic analysis of the role of MFAP4 orthologues in model organisms during development and tissue homeostasis is however lacking. Here, we demonstrate that zebrafish mfap4 transcripts are detected embryonically, resolving to the macrophage lineage by 24 h post fertilization. mfap4 null mutant zebrafish are unexpectedly viable and fertile, without ostensible phenotypes. However, tail fin amputation assays reveal that mfap4 mutants have reduced numbers of macrophages, with a concomitant increase in neutrophilic granulocytes, although recruitment of both cell types to the site of injury was unaffected. Molecular analyses suggest that loss of Mfap4 alters the balance between myeloid and lymphoid lineages during both primitive and definitive haematopoiesis, which could significantly impact the downstream function of the immune system.