bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cinema-going at the Antwerp Zoo (1915–1936): A Cinema-concert Program Database
Authors: Engelen Leen , Crombez Thomas , Winkel Roel Vande 
Published: December 2020

Abstract
This paper outlines the genesis of the cinema-concert program database of the Belgian movie theatre Cinema Zoologie (1915–1936) deposited in the dans repository. First, it provides a detailed account of the historical sources and the data collection process. Second, it explains the structure of the database and the coding that was used to enter the data. Finally, the strengths and weaknesses of the database are discussed and its potential for future research is highlighted.
Identifying Periods of Forecast Model Confidence for Improved Subseasonal Prediction of Precipitation
Authors: Richardson Doug , Black Amanda S. , Monselesan Didier P. , Moore II Thomas S. , Risbey James S. , Schepen Andrew , Squire Dougal T. , Tozer Carly R. 
Published: December 2020

AbstractSubseasonal forecast skill is not homogeneous in time, and prior assessment of the likely forecast skill would be valuable for end-users. We propose a method for identifying periods of high forecast confidence using atmospheric circulation patterns, with an application to southern Australia precipitation. In particular, we use archetypal analysis to derive six patterns, called archetypes, of daily 500-hPa geopotential height (Z500) fields over Australia. We assign Z500 reanalysis fields to the closest-matching archetype and subsequently link the archetypes to precipitation for three key regions in the Australian agriculture and energy sectors: the Murray Basin, southwest Western Australia, and western Tasmania. Using a 20-yr hindcast dataset from the European Centre for Medium-Range Weather Forecasts subseasonal-to-seasonal prediction system, we identify periods of high confidence as when hindcast Z500 fields closely match an archetype according to a distance criterion. We compare the precipitation hindcast accuracy during these confident periods compared to normal. Considering all archetypes, we show that there is greater skill during confident periods for lead times of less than 10 days in the Murray Basin and western Tasmania, and for greater than 6 days in southwest Western Australia, although these conclusions are subject to substantial uncertainty. By breaking down the skill results for each archetype individually, we highlight how skill tends to be greater than normal for those archetypes associated with drier-than-average conditions.
Internal Tide Structure and Temporal Variability on the Reflective Continental Slope of Southeastern Tasmania
Authors: Marques Olavo B. , Alford Matthew H. , Pinkel Robert , MacKinnon Jennifer A. , Klymak Jody M. , Nash Jonathan D. , Waterhouse Amy F. , Kelly Samuel M. , Simmons Harper L. , Braznikov Dmitry 
Published: December 2020

AbstractMode-1 internal tides can propagate far away from their generation sites, but how and where their energy is dissipated is not well understood. One example is the semidiurnal internal tide generated south of New Zealand, which propagates over a thousand kilometers before impinging on the continental slope of Tasmania. In situ observations and model results from a recent process-study experiment are used to characterize the spatial and temporal variability of the internal tide on the southeastern Tasman slope, where previous studies have quantified large reflectivity. As expected, a standing wave pattern broadly explains the cross-slope and vertical structure of the observed internal tide. However, model and observations highlight several additional features of the internal tide on the continental slope. The standing wave pattern on the sloping bottom as well as small-scale bathymetric corrugations lead to bottom-enhanced tidal energy. Over the corrugations, larger tidal currents and isopycnal displacements are observed along the trough as opposed to the crest. Despite the long-range propagation of the internal tide, most of the variability in energy density on the slope is accounted by the spring–neap cycle. However, the timing of the semidiurnal spring tides is not consistent with a single remote wave and is instead explained by the complex interference between remote and local tides on the Tasman slope. These observations suggest that identifying the multiple waves in an interference pattern and their interaction with small-scale topography is an important step in modeling internal energy and dissipation.
Wave Anomaly Detection in Wave Measurements
Authors: Voermans Joey J. , Babanin Alexander V. , Kirezci Cagil , Carvalho Jonas T. , Santini Marcelo F. , Pavani Bruna F. , Pezzi Luciano P. 
Published: December 2020

AbstractQuality control measures for ocean waves observations are necessary to give confidence of their accuracy. It is common practice to detect anomalies or outliers in surface displacement observations by applying a standard deviation threshold. Besides being a purely statistical method, this quality control procedure is likely to flag extreme wave events erroneously, thereby impacting higher-order descriptions of the wave field. In this paper we extend the use of the statistical phase-space threshold, an established outlier detection method in the field of turbulence, to detect anomalies in a wave record. We show that a wave record in phase space (here defined as a diagram of displacement against acceleration) can be enclosed by a predictable ellipse where the major and minor axes are defined by the spectral properties of the wave field. By using the parameterized ellipse in phase space as a threshold to identify wave anomalies, this is a semiphysical filtering method. Wave buoy data obtained from a mooring deployed near King George Island, Antarctica [as part of the Antarctic Modeling Observation System (ATMOS)], and laser altimeter data obtained at the Northwest Shelf of Australia were used to demonstrate the functioning of the filtering methodology in identifying wave anomalies. Synthetic data obtained using a high-order spectral model are used to identify how extreme waves are positioned in phase space.
Molecular adsorbent recirculating system (MARS) and continuous veno-venous hemodiafiltration (CVVHDF) for diltiazem removal: An in vitro study
Authors: Fabresse Nicolas , Larabi Islam Amine , Lamy Elodie , Mégarbane Bruno , Alvarez Jean-Claude 
Published: December 2020

The objective of the present study was to evaluate the efficacy of the molecular adsorbent recirculating system (MARS) vs continuous veno-venous hemodiafiltration (CVVHDF). Diltiazem poisoning was simulated in a central compartment consisting in a 5L dialysis solute spiked with diltiazem at two different toxic concentrations: 750 and 5000 µg/L. For CVVHDF, mean extraction coefficients (EC = (in concentration − out concentration)/in concentration) were concentration-dependent with a decrease all along the dialysis. At the end of the sessions the mean amounts remaining in the central compartment were 8% and 7% of the initial dose at 750 and 5000 µg/L, respectively. The mean cumulative amounts found in the effluent were 60% and 75% of the initial dose, respectively. The missing amounts accounted for 32% and 18% of the initial dose, respectively, corresponding to an adsorption to the dialysis membrane. In contrast, the different compartments of the MARS resulted in undetectable output concentration earlier that the end of the session. The mean concentrations of diltiazem remaining in the central compartment were <1 µg/L at the end of the sessions. Global ECs were around 50% all along the experiment at both concentrations, and the average charcoal cartridge ECs was 80% throughout the experiments. CVVHDF system in the developed model was efficient for diltiazem removal, mainly by diffusion, convection and to a lesser extent by adsorption to the dialysis membrane. In MARS system, resin cartridge and hemodialysis components are ineffective, charcoal cartridge is responsible for almost all drug removal.
Uneven Effects of Adverse Weather Conditions on Participation in Leisure-Time Physical Activities Across Income Levels
Authors: Shi Jingye , Wang Yuting 
Published: December 2020

Purpose: To examine how the effect of adverse weather on participation in leisure-time physical activities (LTPA) varies with income. Design: Cross-sectional study. Subjects: 14,394 individuals from 56 Canadian cities, surveyed in 1992, 1998, and 2005. Measures: The adverseness level of daily weather is measured by the number of hours with precipitation or strong winds (wind speeds in excess of 38 km/hour) between 6 am and 11 pm. Analysis: Probit and multinomial logit models are used to examine the variation in weather-LTPA correlations across income levels. Results: At the mean income level, when the weather quality deteriorated from all-day nice weather to all-day adverse weather, the probability of participating in LTPA decreased by 24.54% (from 0.2424 to 0.1829, P < 0.01). As income increased by $10,000, the same deterioration in weather quality led to a 17.06% decrease in LTPA (from 0.2508 to 0.2080, P < 0.01). The smaller decrease is mainly because the $10,000 increase in income is associated with a 14.49% increase in indoor LTPA, which partly offsets the decrease in outdoor LTPA. Conclusion: Interventions and policies that increase indoor physical activity options, such as providing easier access to indoor facilities and offering subsidies for purchasing or renting home exercise equipment, are promising for effectively promoting LTPA, especially for individuals in lower-income groups or from regions that frequently experience adverse weather.
Correction of Severe Frontal Bossing with Coronal Brow Lift and Osteoplastic Frontal Sinus Setback Aided by Virtual Surgical Planning: A Case Report
Authors: Kumbla Pallavi A. , Thorburn Ashley Q. , de la Torre Jorge I. , Myers René P. 
Published: December 2020

Objective: An 18 year old male with a hypoplastic midface, low anterior hairline, heavy brows and marked frontal bossing presented for evaluation. Laboratory evaluation for acromegaly was negative. He did have impairment of his bilateral visual fields as confirmed by visual field testing by ophthalmology. His nasal radix was also of particular concern to him as it formed a significantly depressed crease between his nasal bridge and his brow. He requested surgical correction of these deformities from both a functional and aesthetic standpoint. Methods: We performed thin-cut CT maxillofacial scanning with 3D reformats and submitted this for virtual surgical planning (VSP). We were able to create a template with which to remove the anterior table of the frontal sinus safely, confidently, and without the aid of a craniotomy. The operation was performed through a preexisting bicoronal incision. The anterior table of the frontal sinus was removed in one piece. His forehead and superior orbits were contoured with a burr. After contouring, the anterior table was fixated in a more recessed position. Nasal radix augmentation was also performed using bone grafting. A coronal brow lift was then performed. Results: The patient’s post-operative course was uneventful. He noted marked improvement in his superior visual fields. He had complete resolution of his nasal radix deformity and his frontal bossing. This was confirmed by thin-cut CT maxillofacial scanning postoperatively. His frontal branches were functionally intact and his hairline was raised to a more appropriate position. Conclusions: Virtual surgical planning allowed us to perform an osteoplastic forehead reduction safely and without older methods such as Caldwell x-rays with coin reference, transillumination, or the bayonet forcep technique. It also allowed us to avoid the use of surgical navigation which can be time consuming and cumbersome. This VSP-based access to the frontal sinus has applications in many aspects of reconstructive cranial surgery as well as aesthetic forehead reductions for patients that do not require a craniotomy.
Impact of a financial incentive on the completion of educational metrics
Authors: Pugh Andrew , Ford Tabitha , Madsen Troy , Carlson Christine , Doyle Gerard , Stephen Robert , Stroud Susan , Fix Megan 
Published: December 2020

Abstract
Background
The Accreditation Council for Graduate Medical Education (ACGME) requires all emergency medicine (EM) training programs to evaluate resident performance and also requires core faculty to attend didactic conference. Assuring faculty participation in these activities can be challenging. Previously, our institution did not have a formal tracking program nor financial incentive for participation in these activities. In 2017, we initiated an educational dashboard which tracked and published all full-time university faculty conference attendance and participation in resident evaluations and other educational activities.

Objectives
We sought to determine if the implementation of a financially-incentivized educational dashboard would lead to an increase in faculty conference attendance and the number of completed resident evaluations.

Methods
We conducted a pre- and post-intervention observational study at our EM residency training program between July 2017 and July 2019. Participants were 17 full-time EM attendings at one training site. We compared the number of completed online resident evaluations (MedHub) and number of conference days attended (call-in verification) before and after the introduction of our financial incentive in June 2018. The incentive required 100% completion of resident evaluations and at least 25% attendance at eligible didactic conference days. We calculated pre- and post-intervention averages, and comparisons were made using a chi-square test.

Results
Prior to implementation of the intervention, the 90-day resident evaluation completion rate was 71.8%. This increased to 100% after implementation (p < 0.001). Conference attendance prior to implementation was 43.8%, which remained unchanged at 41.3% after implementation of the financial incentive (p = 0.920).

Conclusions
Attaching a financial incentive to a tracked educational dashboard increased faculty participation in resident evaluations but did not change conference attendance. This difference likely reflects the minimum thresholds required to obtain the financial incentive.
Differential distribution of manifest lesions in diabetic retinopathy by fundus fluorescein angiography and fundus photography
Authors: Li Xiaoli , Xie Jie , Zhang Liang , Cui Ying , Zhang Guanrong , Wang Jun , Zhang Aiping , Chen Xiangting , Huang Tian , Meng Qianli 
Published: December 2020

Abstract
Background
To analyze the distribution of manifest lesions of diabetic retinopathy (DR) by fundus fluorescein angiography (FFA) and color fundus photography (FP).

Methods
A total of 566 eyes of 324 Chinese patients diagnosed with DR were included in this retrospective study. DR severity was graded by the international grading criterion. The distributions of microaneurysms (MA), intraretinal hemorrhages/exudates (He/Ex), intraretinal microvascular abnormality (IRMA), capillary nonperfusion areas (NPA), and neovascularization (NV) were estimated by multiple logistic regression analyse based on nine-field FFA and FP images.

Results
In mild nonproliferative diabetic retinopathy (NPDR), the highest frequency of MA was found in the posterior pole (67.7%), followed by the inferior nasal (59.4%), and the nasal (55.4%) fields. In moderate NPDR, MA frequently distributed in the posterior pole (98.0%), nasal (97.0%), superior (96.0%), inferior nasal (94.9%), and inferior (92.9%) fields, whereas He/Ex were most prevalent in the posterior pole (69.7%). In severe NPDR and proliferative DR, IRMA, NPA, and NV were more frequent in the nasal field, particularly in the inferior nasal field (60.3, 38.7, and 76.0%, respectively). All lesions were more observed in the combined posterior pole, nasal, and inferior nasal fields than in the posterior pole or combined two fields in the early and severe stages of DR (P < 0.05).

Conclusions
The manifest lesions of DR were common in the nasal field besides the posterior pole in Chinese patients. A combined examination of the posterior pole, nasal, and inferior nasal mid-peripheral retina would help to detect different retinal lesions of DR.

Trial registration
ClinicalTrial. gov, NCT03528720. Registered 18 May 2018 - Retrospectively registered.
Thrombocytopenia and thrombosis in hospitalized patients with COVID-19
Authors: Mei Heng , Luo Lili , Hu Yu 
Published: December 2020

AbstractAs our understanding on coronavirus disease 2019 (COVID-19) deepens, it is increasingly recognized that COVID-19 is more than a respiratory condition. Thrombocytopenia and thromboembolic complications are a composite factor associated with critical COVID-19 and increased mortality. Immune-inflammation-mediated destruction, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection per se and increased consumption are proposed to be responsible for thrombocytopenia. Multiple concomitant conditions or results caused by SARS-CoV-2 infection are high risk factors for thrombosis. Recently, platelet activation and platelet-mediated immune inflammation induced by SARS-CoV-2 infection were also found to be the contributors to the thrombosis in COVID-19 patients. In addition to thrombus scoring system, D-dimer is an excellent indicator for monitoring thrombosis. COVID-19 patients with high risk for thrombosis should be subjected to early thromboprophylaxis, and prolonged activated partial-thromboplastin time should not be a barrier to the use of anticoagulation therapies in the control of thrombosis in COVID-19 patients.
Should ice application be replaced with neurocryostimulation for the treatment of acute lateral ankle sprains? A randomized clinical trial
Authors: Tittley Jean , Hébert Luc J. , Roy Jean‐Sébastien 
Published: December 2020

AbstractStudy designSingle‐blind parallel group randomized clinical trial.ObjectivesTo compare the effects of neurocryostimulation (NCS) with those of traditional ice application on functional recovery, pain, edema and ankle dorsiflexion range of motion (ROM) in individuals receiving physiotherapy treatments for acute lateral ankle sprains (LAS).BackgroundAnkle sprain is a very common injury and its management is often costly, with important short‐ and long‐term impacts on individuals and society. As new methods of therapy using cold (cryotherapy) are emerging for the treatment of musculoskeletal conditions, little evidence exists to support their use. NCS, which provokes a rapid cooling of the skin with the liberation of pressured CO2, is a method believed to accelerate the resorption of edema and recovery in the case of traumatic injuries.MethodsForty‐one participants with acute LAS were randomly assigned either to a group that received in‐clinic physiotherapy treatments and NCS (experimental NCS group, n = 20), or to a group that received the same in‐clinic physiotherapy treatments and traditional ice application (comparison ice group, n = 21). Primary (Lower Extremity Functional Scale ‐ LEFS) and secondary (visual analog scale for pain intensity at rest and during usual activities in the last 48 h, Figure of Eight measurement of edema, and weight bearing lunge for ankle dorsiflexion range of motion) outcomes were evaluated at baseline (T0), after one week (T1), two weeks (T2), four weeks (T4) and finally, after six weeks (T6). The effects of interventions were assessed using two‐way ANOVA‐type Nonparametric Analysis for Longitudinal Data (nparLD).ResultsNo significant group‐time interaction or group effect was observed for all outcomes (0.995 ≥ p ≥ 0.057) following the intervention. Large time effects were however observed for all outcomes (p <  0.0001).ConclusionResults suggest that neurocryostimulation is no more effective than traditional ice application in improving functional recovery, pain, edema, and ankle dorsiflexion ROM during the first six weeks of physiotherapy treatments in individuals with acute LAS.Level of evidenceTherapy, level 1b.Trial registrationClinicalTrials.gov, NCT02945618. Registered 23 October 2016 ‐ Retrospectively registered (25 participants recruited prior to registration, 17 participants after).
Circ6401, a novel circular RNA, is implicated in repair of the damaged endometrium by Wharton’s jelly-derived mesenchymal stem cells through regulation of the miR-29b-1-5p/RAP1B axis
Authors: Shi Qin , Sun Baolan , Wang Di , Zhu Yi , Zhao Xinxin , Yang Xiaoqing , Zhang Yuquan 
Published: December 2020

AbstractBackgroundAccumulating evidence indicates that mesenchymal stem cells (MSCs) exert tissue repair effects and therapeutic angiogenesis through their noncoding RNAs (ncRNAs). Our previous studies showed that MSCs derived from Wharton’s jelly (WJ-MSCs) can ameliorate damaged human endometrium by promoting angiogenesis. There is limited information on the functions and mechanism of ncRNAs in MSC-induced endometrial repair, and additional studies are needed for more insights.MethodsHere, WJ-MSCs were cocultured with or without endometrial stromal cells (ESCs) damaged by mifepristone (cocultured group versus non-cocultured group). TUNEL staining assays, EdU proliferation assays, flow cytometry apoptosis assays, and western blot assays were performed to observe the reparative effect of WJ-MSCs on damaged ESCs. Subsequently, circular RNA (circRNA) and microRNA microarrays were performed between the two groups. A subset of top upregulated circRNAs was validated by qRT-PCR. The functions of circ6401 (hsa_circ_0006401) in WJ-MSCs were investigated using lentivirus-mediated circRNA overexpression assays. The subcellular localization of circ6401 and miR-29b-1-5p in WJ-MSCs was identified by double RNA fluorescence in situ hybridization. Dual-luciferase reporter assays and western blot assays were performed to elucidate the regulatory mechanisms among circ6401, miR-29b-1-5p, and RAP1B.ResultsWJ-MSCs significantly improved ESC proliferation and upregulated the expression of vascular angiogenesis markers. Circ6401 was upregulated in WJ-MSCs cocultured with damaged ESCs, while miR-29b-1-5p was significantly downregulated. Furthermore, circ6401 was found to bind to miR-29b-1-5p and prevent it from decreasing the level of RAP1B, a crucial protein involved in the VEGF signaling pathway, which promoted angiogenesis and stimulated the proliferation of ESCs.ConclusionsOur results showed the abundance and regulation profiles of ncRNAs of WJ-MSCs during repair of damaged ESCs and, for the first time, clarified the underlying mechanism by which circ6401 promotes endometrial repair by WJ-MSCs; thus, demonstrating that circ6401 may serve as a potential therapeutic target.
Effects of corn steep liquor on β-poly(l-malic acid) production in Aureobasidium melanogenum
Authors: Wang Genan , Shi Bingyi , Zhang Pan , Zhao Tingbin , Yin Haisong , Qiao Changsheng 
Published: December 2020

Abstractβ-poly(l-malic acid) (PMLA) is a water-soluble biopolymer used in medicine, food, and other industries. However, the low level of PMLA biosynthesis in microorganisms limits its further application in the biotechnological industry. In this study, corn steep liquor (CSL), which processes high nutritional value and low-cost characteristics, was selected as a growth factor to increase the PMLA production in strain, Aureobasidium melanogenum, and its metabolomics change under the CSL addition was investigated. The results indicated that, with 3 g/L CSL, PMLA production, cell growth, and yield (Yp/x) were increased by 32.76%, 41.82%, and 47.43%, respectively. The intracellular metabolites of A. melanogenum, such as amino acids, organic acids, and key intermediates in the TCA cycle, increased after the addition of CSL, and the enrichment analysis showed that tyrosine may play a major role in the PMLA biosynthesis. The results presented in this study demonstrated that the addition of CSL would be an efficient approach to improve PMLA production.