bluuebunny/crossref_metadata_2025_split huggingface dataset:
Be Quiet and Man Up: A Qualitative Study into Men Who Experienced Birth Trauma
Authors: Daniels Emily , Arden-Close Emily , Mayers Andrew 
Published: November 2019

Abstract
Background: Research focusing on paternal mental health is limited and the consequences of this are ignored. For example, little is known about the experiences of men who witness their partner’s traumatic birth and the subsequent impact. Therefore, the aim of this study was to explore men’s experiences of witnessing a traumatic birth, how these experiences impacted on their wellbeing, and what support they received during and following the traumatic birth. Methods: Sixty-one participants were recruited via targeted social media to complete an online qualitative questionnaire regarding their birth trauma experience. Eligible participants were aged over eighteen, resided in the UK and had witnessed a traumatic birth that did not result in loss of life. Thematic analysis was used to analyse the questionnaire data. Results: Three main themes were identified: ‘fathers’ understanding of the experience’ (subthemes: nothing can prepare you for it; merely a passenger; mixed experiences with staff; not about me); ‘life after birth trauma’ (subthemes: manhood after birth; inability to be happy; impact on relationships); and ‘the support fathers received vs what they wanted’ (subthemes: prenatal support; birth support; and postnatal support). Conclusions: Fathers reported significant experiences during childbirth when they had witnessed their partner’s traumatic birth. They felt this impacted on their mental health and relationships long into the postnatal period. However, there is no nationally recognised support in place for fathers to use as a result of their experiences. The participants attributed this to being perceived as less important than women in the perinatal/childrearing period, and maternity services’ perceptions of the father more generally. Implications include ensuring support is given to all involved in the perinatal period, with additional staff training geared towards the father’s role.
Psychometric Testing of the Support and Control in Birth Scale
Authors: Liu Shuyu , Lu Yu-Ying , Gau Meei-ling , Liu Chieh-Yu 
Published: November 2019

Abstract
Background The Support and Control in Birth (SCIB) scale primarily measures the perceived support and control of expectant mothers during childbirth, thereby obtaining an understanding of their birth experiences. The advantages of this scale are its good reliability and validity and that it consolidates birth support and control. However, a Chinese version of the scale has yet to be developed. This study aim is evaluate the validity and reliability of the Chinese version of the Support and Control in Birth Scale (SCIB).Methods A total of 228 postpartum women participated in this study. The Chinese version of the SCIB (C-SCIB) scale was developed through a translation and back translation, followed by an evaluation of its expert validity and content validity. Cronbach's α and test-retest reliability were used to test the internal consistency reliability of the scale. In addition, criterion-related validity (predictive validity and concurrent validity) and construct validity were used to test the validity of the scale.Results 1. The confirmatory factor analysis results showed the overall goodness-of-fit was parsimony fit indices. 2. The reliability was .81, and its test-retest reliability was .96. 3. The criterion-related validity was test the predictive validity and concurrent validity. The predictive validity showed that a significant correlation ( r =.31, p <.01). There was a significant correlation between all the dimensions in the C-SCIB scale, such as internal control ( r =.15, p <.05), external control ( r =.30, p <.01), and support ( r =.21, p <.01). Furthermore, the concurrent validity showed a significant and moderate correlation ( r =.50, p < .01).Conclusion The C-SCIB scale was proven to have good reliability and validity, and thus can be used to measure the degree of support and the locus of control perceived by expectant women during labor.
Maternal Perceptions of Cesarean Delivery Care: A Qualitative Study to inform ERAS Guideline Development
Authors: Wollny Krista , Metcalfe Amy , Corrigan Crystal , Drobot Ashley , Gilmour Loreen , Wood Stephen , Wilson R. Douglas , Gramlich Leah , Nelson Gregg 
Published: November 2019

Abstract
INTRODUCTION: Cesarean delivery (CD) is the most common inpatient surgical procedure; however, there are no internationally-accepted, standardized clinical guidelines. The Enhanced Recovery After Surgery (ERAS®) program aims to improve outcomes through the development of international guidelines (IG). The purpose of this study is to obtain and consolidate women’s experiences with CD to inform the development of an ERAS international guideline (IG). METHODS: Qualitative methods were used to assess the patient experience with current evidence-based CD protocols across operative phases. Twelve women who experienced CD were interviewed using an open-ended, semi-structured interview guide at six-weeks post-partum. Two researchers coded the emerging themes separately and compared findings. RESULTS: Women described feeling informed, but felt they did not have a choice. Pre-surgery, women wanted more information about the risks of CD. Pre-operatively, women expressed confusion with the procedures, but felt informed about local anaesthesia and thermoregulation. Post-CD, women felt informed about pain and nausea control; however, urinary catheter removal was delayed when compared to the ERAS recommendations. Information about post-partum infant care was not well communicated, as many women were uninformed about delayed cord-clamping and infant thermoregulation. DISCUSSION: This qualitative study provides opportunities to improve communication, the patient-provider relationship, and the overall satisfaction throughout the CD process. The findings support the implementation of patient decision aids and training with the shared decision model. The improved procedures recommended in the ERAS IG for CD have the potential to deliver significant improvements to patient satisfaction, mother-infant bonding and mental wellness.
Change in expression of 5-HT6 receptor at different stages of Alzheimer’s disease: a postmortem study with the PET radiopharmaceutical [ 18F ]2FNQ1P
Authors: Courault Pierre , Emery Stéphane , Bouvard Sandrine , Liger François , Chauveau Fabien , Meyronet David , Fourier Anthony , Billard Thierry , Zimmer Luc , Lancelot Sophie 
Published: November 2019

Abstract
Background The aim of this study was to investigate the binding of [18F]2FNQ1P, a new specific radiotracer of 5-HT6 receptors, and to quantify 5-HT6 receptor density in caudate nucleus in a population of patients with different Alzheimer’s disease (AD) stages.Methods Patients were classified according to the “ABC” NIA-AA classification. In vitro binding assays were performed in postmortem brain tissue from the control (“Not”; n=8) and severe AD (“High”; n=8) groups. In vitro quantitative autoradiography was performed in human brain tissue (caudate nucleus) from patients with different stages of AD: “Not” (n=15), “Low” (n=18), “Int” (n=20) and “High” (n=15).Results In vitro binding assays did not show significant differences for the KD and Bmax parameters between “High” and “Not” groups. In vitro quantitative autoradiography showed a significant difference between the “High” and “Not” groups (p-value = 0.0025). We also showed a progressive diminution in [18F]2FNQ1P specific binding, which parallels 5-HT6 receptors expression, according to increasing AD stage. Significant differences were observed between the “Not” group and all AD stages combined (“Low”, “Intermediate” and “High”) (p-value = 0.011).Conclusions This study confirms the interest of investigating the role of 5-HT6 receptors in AD and related disorders. [18F]2FNQ1P demonstrated specific binding to 5-HT6 receptors.
Variable versus constant frequency deep brain stimulation in patients with advanced Parkinson’s disease: study protocol for a randomized controlled trial
Authors: Jia Fumin , Zhang Jianguo , Wang Huimin , Liang Zhanhua , Liu Weiguo , Wang Xuelian , Liu Yiming , Guo Yi , Ling Zhipei , Cai Xiaodong , Wu Xi , Wu Jianjun , Lv Wen , Xu Xin , Zhang Wenbin , Li Luming 
Published: November 2019

Abstract
Background: Deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) can be used to treat motor symptoms and dyskinesia in the advanced stages of Parkinson’s disease (PD). High frequency stimulation (HFS) of the STN can lead to consistent, long-term improvement of PD symptoms. However, the effects of HFS on the axial symptoms of PD, specifically freezing of gait (FOG), can be limited or cause further impairment. While this can be alleviated via relatively low frequency stimulation (LFS) in select patients, LFS does not control all motor symptoms of PD. Recently, the National Engineering Laboratory for Neuromodulation reported preliminary findings regarding an efficient way to combine the advantages of HFS and LFS to form variable frequency stimulation (VFS). However, this novel therapeutic strategy has not been formally tested in a randomized trial. Methods/Design: We propose a multicenter, double blind clinical trial involving 12 study hospitals and an established DBS team. The participants will be divided into a VFS and a constant frequency stimulation (CFS) group. The primary outcome will be changes in Stand-Walk-Sit (SWS) task scores at three months of treatment in the “medication off” condition. Secondary outcome measures include specific item scores on the Freezing of Gait Questionnaire and quality of life. The aim of this trial is to investigate the efficacy and safety of VFS compared with CFS. Discussion: This is the first randomized controlled trial to comprehensively evaluate the effectiveness and safety of VFS of the STN in patients with advanced PD. VFS may represent a new option for clinical treatment of PD in the future. Trial registration: The present protocol is registered at ClinicalTrials.gov: NCT03053726.
Better efficacy in differentiating WHO grade II from III oligodendrogliomas with machine-learning than radiologist’s reading from conventional T1 contrast-enhanced and fluid attenuated inversion recovery imagines
Authors: Zhao Sha-Sha , Feng Xiu-Long , Hu Yu-Chuan , Han Yu , Tian Qiang , Sun Ying-Zhi , Zhang Jie , Ge Xiang-Wei , Cheng Si-Chao , Li Xiu-Li , Mao Li , Shen Shu-Ning , Yan Lin-Feng , Cui Guang-Bin , Wang Wen 
Published: November 2019

Abstract
Background: The medical imaging to differentiate World Health Organization (WHO) grade II (ODG2) from III (ODG3) oligodendrogliomas still remains a challenge. We investigated whether combination of machine leaning with radiomics from conventional T1 contrast-enhanced (T1CE) and fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) offered superior efficacy. Methods: Thirty-six patients with histologically confirmed ODGs underwent T1CE and 33 of them underwent FLAIR MR examination before any intervention from January 2015 to July 2017 were retrospectively recruited in the current study. The volume of interest (VOI) covering the whole tumor enhancement were manually drawn on the T1CE and FLAIR slice by slice using ITK-SNAP and a total of 1072 features were extracted from the VOI using 3-D slicer software. Random forest (RF) algorithm was applied to differentiate ODG2 from ODG3 and the efficacy was tested with 5-fold cross validation. The diagnostic efficacy of radiomics-based machine learning and radiologist’s assessment were also compared. Results: Nineteen ODG2 and 17 ODG3 were included in this study and ODG3 tended to present with prominent necrosis and nodular/ring-like enhancement (P < 0.05). The AUC, ACC, sensitivity, and specificity of radiomics were 0.798, 0.735, 0.672, 0.789 for T1CE, 0.774, 0.689, 0.700, 0.683 for FLAIR, as well as 0.861, 0.781, 0.778, 0.783 for the combination, respectively. The AUCs of radiologists 1, 2 and 3 were 0.700, 0.687, and 0.714, respectively. The efficacy of machine learning based on radiomics was superior to the radiologists' assessment. Conclusions: Machine-learning based on radiomics of T1CE and FLAIR offered superior efficacy to that of radiologists in differentiating ODG2 from ODG3.
Self-adaptive multi-population-based Jaya algorithm to optimize the cropping pattern under a constraint environment
Authors: Kumar Vijendra , Yadav S. M. 
Published: November 2019

Abstract
Increasing population around the world, especially in India and China, has resulted in a drastic increase in water intake in both domestic and agricultural sectors. This, therefore, requires that water resources be planned and controlled wisely and effectively. With this consideration, the aim of the study is to achieve an optimal cropping pattern under a constrained environment. The objective is to maximize the net benefits with an optimum use of water. For optimization, a self-adaptive multi-population Jaya algorithm (SAMP-JA) has been used. For the Karjan reservoir in Gujarat State, India, two different models, i.e. maximum and average cropping patterns, were formulated based on the 75 per cent dependable inflow criteria. These two model scenarios are developed in such a way that either model can be selected by the farmer based on the crop area and its respective net benefits. Invasive weed optimization (IWO), particle swarm optimization (PSO), differential evolution (DE) and the firefly algorithm (FA) were compared to the results. The results show that the SAMP-JA obtained the maximum net benefit for both the models. The findings of the research are also compared with the actual cropping pattern. A significant increase has been noted in the cultivation of sugarcane, groundnut, wheat, millet, banana and castor. SAMP-JA has been noted to converge faster and outperforms PSO, DE, IWO, FA, teaching–learning-based optimization (TLBO), the Jaya algorithm (JA), elitist-JA and elitist-TLBO.
DIGITAL FINANCIAL ASSETS: SEGMENTS AND PROSPECTS OF LEGAL REGULATION IN THE BRICS COUNTRIES
Authors: Sarnakov I. 
Published: November 2019

In the environment of the current trend towards digitalization of the world economy, the issue of the legal regulation of the institute of digital financial assets as well as the activity relating to the generation of these assets is of considerable interest. As practice shows, individual countries face the situation where these assets are already turning over, but there is still no legal regulation. This state of affairs may give rise to cases of illegal turnover of financial assets and fraud in this sphere. Presently, the geopolitical map on digitalization of the economy is fragmented. Some countries have recognized and legalized the turnover of digital financial assets, others have so far not adopted an unambiguous attitude with respect to this new institute, while a third group of countries has not even recognized their legal nature nor their very existence. This ambiguity raises many issues relating to the legitimacy of digital financial assets and the feasibility of the introduction of this new financial product. The article analyzes the state of the legal regulation of the institute of digital financial assets in the BRICS countries, considers the standpoints of legislators and scientists on the legal nature of these financial assets.
The Oleaster (Elaeagnus angustifolia): A Comprehensive Review on Its Composition, Ethnobotanical and Prebiotic Values
Authors: Sabouri Sima , Rad Aziz H. , Peighambardoust Seyed H. , Fathipour Raana B. , Feshangchi Javad , Ansari Fereshteh , Pourjafar Hadi 
Published: November 2019

Background:
Oleaster or Elaeagnus angustifolia is a deciduous plant from Elaegnacea family
and is well-known for its remedial applications.

Objective:
This paper presents a comprehensive review of the potential application of Oleaster's flour
incorporated in some food products. Emphasis is given to the physicochemical, biochemical, and functional
properties of Oleaster's flour.

Methods:
A comprehensive search was carried out to find publications on Oleaster’s flour and its application
as a prebiotic. The results of the related studies were extracted and summarized in this paper.

Results:
Oleaster's flour as a prebiotic ingredient enhances antioxidants, polyphenols, fiber, flavonoids,
Sterols, carbohydrates, and protein content of food products.

Conclusions:
Further advanced investigations on Oleaster and its functional ingredients revealed that
these are efficacious and can be applied as a substitute source in pharmacological industries for medical
applications.
Possible Selective Cytotoxicity of Vanadium Complex on Breast Cancer Cells Involving Pathophysiological Pathways
Authors: El-Shafey Eman S. , Elsherbiny Eslam S. 
Published: November 2019

Background:
Triple-Negative Breast Cancers (TNBC) are among the most aggressive and therapyresistant
breast tumors. Development of new treatment strategies that target pathways involved in cancer cells
resistance is an attractive candidate to overcome therapeutic resistance.

Objective:
To clarify the antitumor activity of [VO (bpy)2 Cl] Cl complex as a new therapeutic agent through
studying the interplay between apoptosis, autophagy and notch signaling pathways.

Methods:
Proliferation of MDA-MB-231 cells and IC50 value of the vanadium complex were assessed by MTT
assay. Flow cytometry was utilized to detect cell cycle distribution, apoptosis assay, LC3 levels and Acid
Vascular Organelles (AVOs). Caspase 3 levels were detected by ELISA. Changes in Notch1 gene expression
were assessed by real-time PCR. AVOs qualitative detection was assessed by a fluorescence microscope.

Results:
The growth of MDA-MB-231 cells was suppressed after treatment with [VO (bpy)2 Cl] Cl complex, in
a dose-dependent manner. The affinity for apoptotic cell death induction was shown through the increase in the
sub G0 peak, the percentage of early and late apoptotic phases, and the elevation in caspase 3 levels. The affinity
for autophagic cell death induction was observed through the increase in the G0/G1 phase, G2/M arrest, the
increase of AVOs red fluorescence and elevated LC3 levels. The affinity for notch pathway inhibition was
shown through the suppression of Notch 1 gene expression.

Conclusion:
[VO (bpy)2 Cl] Cl complex could be a promising candidate as therapeutic agent targeting different
therapeutic targets including apoptosis, autophagy and notch signaling pathways.
A Review on Ethnobotanical, Phytochemical, Pharmacological and Traditional Aspects of Indigenous Indian Herb Trachyspermum ammi (L)
Authors: Saraswat Nikita , Sachan Neetu , Chandra Phool 
Published: November 2019

Introduction and Ethnopharmacological relevance:
In the Indian Vedic literature,
Charakasamhita and Sushritasamhita, the Ajwain is known as Bhootika and in the
charaksamhita commentaries, it is termed as Yavanika. The medicinal role of Ajwain fruit is
claimed to be very important in the treatment of many ailments in humans. The plant Trachyspermum
ammi Linn. is a grassy, aromatic annual plant, which falls in the family Umbelliferae.
This plant is grown in India, Iran, Pakistan, Egypt, etc. for its medicinal benefits.
Tribals of India use it for the treatment of diarrhea, arthritis, colic and gastrointestinal problems.
In the traditional preparations, Indian Vaidya guru’s (Ayurveda Guru’s), the ajwain extract
is used as “Admoda Arka”. The Ayurveda doctors, hakims and Vaidya gurus recommend
ajwain for treating headaches, cold, flu and even during painful menstrual periods.

Aim of the Study:
The review paper has compiled the researches conducted on Trachyspermum
ammi, which will help in presenting a collective data of the authentic researches conducted
on the plant worldwide. It will also present information about the phytoconstituents
which can be useful for building up new researches in near future.

Materials and Methods:
This paper has been prepared by collecting all the information
available on the following platforms and the papers were searched from 1975 to 2019. The databases
and electronic journals were well searched including Wiley, Springer link, Google
Scholar, Science Direct, Pubmed. The key terms used for the search were Ajwain, C. copticum,
Trachyspermum ammi and other synonyms of the plant. The search was also done by the
names of chemical constituents present in the plant and the pharmacological effect of the plant.

Results:
The multiple uses of T. ammi are due to the active constituents present in it. As per
the phytochemical studies on the fruits of T. ammi, the presence of various phytoconstituents
has been found such as saponins, flavonoids, alkaloids, glycosides, fixed oils, thymenes,
cumenes, tannins, amino acids, p-cymene, c-terpinene, steroids, etc.

Conclusions:
This paper is focused on presenting a detailed review on the literature, pharmacological
properties, physicochemical studies and the newest researches on the plant. In this
paper, we have also compiled the traditional uses of the herb used by Indian peopleon recommendations
from their Hakims, Vaidya and use of the herbs by many tribes all across India
and Pakistan.
The effectiveness of content based on dynamic intellectual learning with visual modality in vocational school
Authors: Agustini Ketut , Sindu I Gede Parta , Kusuma Kadek Angga 
Published: November 2019

E-learning generally presented the same learning material because it considered the characteristics of all users to be homogeneous. In fact, every student had different characteristics in the learning process. The objectives of this study were: (1) To produce a simulation content and digital communication based on Dynamic Intellectual Learning with Visual Modality for the tenth grade at SMK Negeri 1 Seririt, (2) To find out the teacher's response and the tenth grade students at SMK Negeri 1 Seririt on Simulation Content and Digital Communication based on DIL with Visual Modality that had been generated. The method of this study was a research and development referred to the plomp model. The subjects of this study were the tenth grade of accounting program at SMK Negeri 1 Seririt in the academic year 2017/2018. There were various try out had been carried out, namely: validity testing by experts and effectiveness testing by using the Hake formula. The results showed that the simulation content and digital communication based on DIL with Visual Modality was valid and practically use: the effectiveness testing produced N-gain of 0.74 included in the effective category and the data analysis of the teacher and the students respond showed that it was categorized in the positive category. It showed that the output was valid, practical and effective to be used.
IMPROVING STUDENT’S MATHEMATICS LEARNING ACTIVITIES AND OUTCOMES USING MATHEMATICAL BAGATRIX AND POWER POINT SOFTWARE
Authors: Sudarsono Andri , Supiyanto Supiyanto , Batori Batori , Hidayat Teguh Imam Agus 
Published: November 2019

The purpose of this study is to analyze students’ mathematics learning activities and outcomes using mathematics instruction assisted by ICT mathematical Bagatrix software and PowerPoint. This study is a classroom action research in three cycles, on a linear equation of one variable (LEOV) and involves 20 seventh grade students of SMP Citra Cemara in Bandung. The study found that students’ mathematics learning activities increased during each cycle, likewise, students’ mathematics learning outcomes and percentage of the number of students who reached mastering LEOV (more than 70% out of ideal score) heightened at end of each cycle. Another finding is that students perform positive opinion toward implementation of mathematics instruction assisted by ICT mathematical Bagatrix software and PowerPoint.