bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vivências das famílias no cuidado aos recém-nascidos prematuros no domicílio: revisão sistemática qualitativa
Authors: Felizardo Melissa Joice de Abreu , Henriques Nayara Luiza , Silva Juliana Barony da , Macêdo Maísa Mara Lopes , Charepe Zaida Borges , Duarte Elysângela Dittz 
Published: December 2020

Objetivo: Analisar como as famílias vivenciam o cuidado domiciliar às crianças prematuras egressas da Unidade de Terapia Intensiva
Neonatal. Método: Revisão sistemática qualitativa, realizada em 7 bases eletrônicas de dados e construída conforme as diretrizes
propostas pelo Joanna Briggs Institute e o guia internacional PRISMA. Incluiram-se 27 estudos, considerando-se: tipo de estudo; ano
de publicação; idioma; população e contexto do estudo e artigos disponíveis em full text. Os estudos incluídos foram avaliados quanto
à qualidade metodológica e, posteriormente, lidos na íntegra. Os dados qualitativos extraídos foram agrupados em códigos e,
seguidamente, analisados. Resultados: O cuidado às crianças prematuras egressas da UTIN exige mudanças na organização familiar
e os profissionais de saúde são identificados como a principal fonte de informação e segurança. Nota-se o envolvimento de todos os
membros da família nos cuidados iniciais, e a criança torna-se o foco da família, que compartilha sentimento de alegria e felicidade,
medo e insegurança no que tange aos cuidados com as crianças. Conclusão: A proximidade com o filho após a alta é relatado pelos
pais como positivo, entretanto, o cuidado pode ser permeado por dificuldades e incertezas, reforçando a importância do apoio dos
familiares e dos profissionais de saúde.
Pistas para análise da violência contra as mulheres em tempos de crise: aproximações e desafios no contexto de pandemia no Brasil
Authors: Barroso Milena Fernandes 
Published: December 2020

The new coronavirus pandemic that hit the planet has demonstrated the structural crisis of capital and, far from proving itself a “democratic” infection, brought about breakdowns in many countries, revealing contradictions, inequalities and the limits of capitalism as a mode of production and reproduction of life. In this article, we seek an approach to analyze violence against women in this context, acknowledging it as both product and producer of a system that increasingly demands the body-territory of women in particular for its maintenance. Therefore, from an enlarged reading of violence against women, the text shows connections between many expressions of this violence and its centrality to new forms of capital accumulation in critical times, which, in a pandemic setting, become ever-increasingly exacerbated forms of exploitation and oppression of women, women of color in particular.
The Strategy of Phytoplankton on Critical Conditions in Coastal Waters
Authors: Tambaru Rahmadi , Samawi Muh. Farid , Amri Khairul 
Published: December 2020

The productivity of phytoplankton found best in coastal waters is on a critical aquatic environmental condition for the life of phytoplankton (incubation time : 10.00-14.00). At that incubation time, the sun reached the apex of illumination (12.00). Theoretically, the best productivity is unlikely to happen because the activity of phytoplankton is not perfect. To answer that doubt, the research deals with the strategy of life phytoplankton on critical conditions in coastal waters. To achieve the desired results, multivariate analysis is used Correspondent analysis (CA) and Principal Components Analysis (PCA). The results showed that based on the analysis of Factorial Koresponde (CA), there were two grouping of phytoplankton abundance. Group I showed that the grouping of phytoplankton abundance of occurred at A depth of 10 m at the sampling time A (10.00 : normal conditions). Group II occurs at a depth of 5 and 15 m at sampling time B (14.00: critical condition). Furthermore, the shift in grouping phytoplankton occurs at the sampling time A at a depth of 10 m into the sampling time B in 5 m depth, not at at a depth of 0 m. This is due to the very strong sunlight intensity that can lead to death in the genera of phytoplankton that exist. It turns out that the strategy and the dynamics of phytoplankton abundance at critical time is not doing the grouping at the surface depth (0 m), but at a deeper depth (5 m) in order to keep the activity well done.
Advantages of Hybrid Corn Seed Production Compared to Corn Grain
Authors: Bahtiar Bahtiar , Zanuddin B , Azrai M 
Published: December 2020

Corn seed breeders are indispensable in the supply of superior hybrid corn seeds. Its ability to produce seeds is evaluated for their superiority compared to the production of corn grain yield. A study was conducted in Jatirogo District, Tuban Regency, East Java province in July to December 2019. Involving farmers cooperator implementing hybrid corn seed production in the area of 96 ha and non cooperator farmers who produce the corn grain yield in the same location. We observed the variables: cost of production, yield and farmers income. Data and information were analyzed by Benefit Cost Ratio (B/C) and Marginal Benefit Cost Ratio (MBCR). The results showed that farmers who produced hybrid corn seeds of Nasa-29 variety (cooperators) were able to produce 4.6 t/ha of wet cobs with an income of IDR. 19,470,000/ha, while farmers who produced grain corn of 7.9 t/ha with an income of IDR. 15,943,000/ha. MBCR analysis showed that, the switching is able to added the farmer income Rp.4,100 for every use cost Rp.1,000 as long as the seed procurement policy remains unchanged and related institutions continue to provide support.
Attributes of Coffee Shop as Antecedent of Customer Satisfaction
Authors: Darussalam Ridwan 
Published: December 2020

Purpose – This study was conduct to examine the effect of attributes coffee shop to customer satisfaction in Indonesian coffee shop industry. Furthermore, this study is also examined customer loyalty as consequences of customer satisfaction

Research Design – Five attributes of coffee shop were identified as having potential to be antecedent of customer satisfaction. The five attributes were: store atmosphere, employee attitude, IT service, coffee quality, and price fairness.
Research Methodology – This study used online questionnaire which is adopted from the previous studies. The online questionnaires were used Google Form and shared through various social media platform. A total 851 respondents from 34 province in Indonesia were involved but only 350 respondents were qualified. KMO Factor analysis and regression analysis were performed to identify the validity of items and examine the relationship among variables.
Findings – The results revealed that five of six hypothesized were statistically significant. Coffee quality was recognized as attribute of coffee shop which is produce the highest effects to customer satisfaction. Moreover, the relationship between customer satisfaction and customer loyalty was found positive.
API Connection Leak Equation Extended with Dependence on Axial Force and Backup Pressure
Authors: Goodman Malcolm A. , Mitchell Robert F. , Kalil Issa A. 
Published: December 2020

Summary
The existing American Petroleum Institute (API) equation for internal leak predicts the internal pressure to overcome the pin-box contact pressure generated from the makeup interference plus the energizing effect of internal pressure, which enhances the seal. For threaded connections, internal and external pressures close the connection and increase the leak resistance, whereas axial loads open the connection and decrease the leak resistance. These competing effects must be included to accurately assess the connection leak resistance under any combination of loads at any point in any string. Following the same approach used by the API for internal leak, this paper obtains similar results for external leak. For API connections, the effects of combined axial force and backup pressure are then incorporated into the internal/external leak equations using results from a “toy connector” elastic model. Sensitivities of leak ratings to combined loads for API connections are presented for both tubing and casing sizes. An example design case shows the importance of considering combined loads.
Transcriptome analysis and molecular mechanism of linseed (Linum usitatissimum L.) drought tolerance under repeated drought using single-molecule long-read sequencing
Authors: Wang Wei , Wang Lei , Wang Ling , Tan Meilian , Ogutu Collins O. , Yin Ziyan , Zhou Jian , Wang Jiaomei , Wang Lijun , Yan Xingchu 
Published: December 2020

Abstract
Background: Oil flax (linseed, Linum usitatissimum L.) is one of the most important oil crops., However, the increases in drought resulting from climate change have dramatically reduces linseed yield and quality, but very little is known about how linseed coordinates the expression of drought resistance gene in response to different level of drought stress (DS) on the genome-wide level.Results: To explore the linseed transcriptional response of DS and repeated drought (RD) stress, we determined the drought tolerance of different linseed varieties. Then we performed full-length transcriptome sequencing of drought-resistant variety (Z141) and drought-sensitive variety (NY-17) under DS and RD stress at the seedling stage using single-molecule real-time sequencing and RNA-sequencing. Gene Ontology (GO) and reduce and visualize GO (REVIGO) enrichment analysis showed that upregulated genes of Z141 were enriched in more functional pathways related to plant drought tolerance than those of NY-17 were under DS. In addition, 4436 linseed transcription factors were identified, and 1190 were responsive to stress treatments. Moreover, protein-protein interaction (PPI) network analysis showed that the proline biosynthesis pathway interacts with stress response genes through RAD50 (DNA repair protein 50) interacting protein 1 (RIN-1). Finally, proline biosynthesis and DNA repair structural gene expression patterns were verified by RT- PCR.Conclusions: The drought tolerance of Z141 may be related to its upregulation of drought tolerance genes under DS. Proline may play an important role in linseed drought tolerance by maintaining cell osmotic and protecting DNA from ROS damage. In summary, this study provides a new perspective to understand the drought adaptability of linseed.
Operating Room Nurses’ Lived Experiences of Ethical Codes: A Phenomenological Study
Authors: Aghamohammadi Fatemeh , Imani Behzad , Koosha Mahnaz Moghaddami 
Published: December 2020

Abstract
BackgroundOperating room nurses, who are important members of health teams and who serve in an environment full of ethical and work challenges, often face situations that require them to make decisions based on ethical principles. Therefore, compiling ethical codes appropriate to the culture and religion of the community is a good way to improve the quality of nursing services expected by stakeholders.ObjectiveThe purpose of this study was to examine Operating room nurses’ lived experiences of ethical codes. Research design and methodA hermeneutic phenomenological study was performed. Participants were 10 operating room nurses who were selected by purposive sampling. Data were collected through in-depth and semi-structured interviews. Data analysis was performed based on Van Manen methodology.ResultsData analysis revealed 3 main themes and 12 sub-themes that showed the experience of operating room nurses from ethical codes. The main themes were: Adherence to professional commitments, preserving patient dignity and respect for colleagues.ConclusionThe results of this study showed the ethical experiences of operating room nurses. These findings determine the ethical codes in the operating room. It is suggested that using these codes, a guide, and a model be developed to improve the ethical and professional performance of operating room nurses.
Effects of Low-Intensity Pulsed Ultrasound on the Proliferation of Human Umbilical Cord Mesenchymal Stem Cells and Their Chondrogenic Differentiation via Bmp2 /Smad Signaling Pathway
Authors: JIN Xuhong , Wang Hejie , Che Jiaju , Chen Xiafu , Huang Dengao , Zhuo Zeming , Xing Shi 
Published: December 2020

Abstract
BackgroundAlthough Low-intensity pulsed ultrasound (LIPUS) regiment has been applied to the treatment of cartilage injury clinically, the effect of LIPUS stress loading on the proliferation and differentiation of hUCMSCs is still controversial. Yet the specific mechanical mechanism of LIPUS stimulates cartilage differentiation of hUCMSCs has not been clarified.ObjectiveTo investigate the effects of low intensity pulsed ultrasound (LIPUS) on proliferation and chondrogenic differentiation of human umbilical cord mesenchymal stem cells (hUCMSCs) via BMP2 /smad signaling pathway in vitro.MethodThe hUCMSCs at P4 were randomly divided into control group(no LIPUS), L30 group (30mW/cm2), L50 group (50mW/cm2), L80 group (80mW/cm2), each LIPUS group respectively loaded 5, 10, 20 min/d, the cell proliferation activity was detected by CCK-8 assay after continuous irradiation for 5 days. For chondrogenic differentiation, hUCMSCs were divided 4 groups as follows: control group, Noggin group, LIPUS group, Noggin+LIPUS group, LIPUS irradiation was given 50w/cm2, 5min/d. Cartilage formation after 3 weeks was evaluated by Alician blue staining for GAG and COL II immunohistochemical staining. Furthermore, RT-PCR analysis of Sox-9, COL II Aggrecan, BMP2, Smad1, Smad5 and Smad9. Result： (1) The proliferation activity of L50 group(50w/cm2 , 5min/d) was noticeably higher compared with other groups, Alcian blue staining of GAG , COL II fluorescent staining in the LIPUS group were much stronger, quantitative RT-PCR assays showed that the expression of COL II, GAG, Sox-9, smad1, smad5 and smad9 in LIPUS group was significantly increased. Conclusion：The suitable LIPUS irradiation can promote cell proliferation, 50mW/cm2 intensity at 5min/d is most significant. And it can promote chondrogenesis of hUCMSCs via upregulating MP2 /smads signaling pathway.
Quality of Life of Breast Cancer Patients in Amhara Region, Ethiopia: A Cross-Sectional Study
Authors: Alem Tamrat , Nigatu Dabere , Birara Amsalu , Fetene Tamene , Giza Mastewal 
Published: December 2020

Abstract

BackgroundAlthough breast cancer has a markedly higher incidence in developed countries, 50% of the new diagnosis and 70% of deaths occur in developing countries. There are limited data available on the quality of life among breast cancer patients in Ethiopia, notably in the Amhara region. This study aimed to assess the quality of life and associated factors among patients with breast cancer in the Amhara Region, Ethiopia, 2019.MethodsInstitutional based cross-sectional study was conducted from March 25 to July 7/2019 among 256 patients with breast cancer in the Amhara region. A systematic random sampling technique was used. Data were collected by using a standardized interviewer-administered Amharic version of the European Organization for research and treatment of cancer quality of life questionnaire core 30(EORTC QLQ C30) and breast cancer supplementary measure (QLQ-BR23). Data were analyzed by SPSS version 23. A binary logistic regression model was fitted to identify the associated factors. The odds ratio (OR) with 95% confidence interval (CI) was used to measure the strength of association.ResultsSixty-eight point four percent (68.4%) of breast cancer patient's QoL was poor. The mean score of quality of life was 70.6(standard deviation (SD) ±13.9; 95% CI: 69.0-72.4). All functional component scores were less than 75, from the symptom scale; diarrhea (11.6), constipation (17.5), and dyspnea (24.7) were less noticeable. Unmarried patients (AOR=2.59, 95% CI: 1.32-5.07), poor (AOR=2.39, 95%CI: 1.32-5.03), non housewife (AOR=3.25, 95% CI: 1.16-7.22), and complaints to dyspnea (AOR=3.48, 95% CI: 1.79-6.79), and insomnia (AOR=2.03, 95% CI: 1.05-3.91) were significantly associated with quality of life.ConclusionsHealth care professionals should give attention to unmarried, and non-housewife breast cancer patients, besides the treatment to improve the health of breast cancer patients.
ApoE4-carrying Human Astrocytes Oversupply Cholesterol into Neurons and Promote Aβ Generation
Authors: Lee Se-In , Jeong Woojin , Cho Sukhee , Lee Hyein , Jang Yonghee , Lin Yuan-Ta , Tsai Li-Huei , Seo Jinsoo 
Published: December 2020

Abstract
The onset of Alzheimer’s disease (AD) typically occurs later in life. Importantly, however, recent genetic analysis of patients and unaffected individuals revealed multiple genetic variants associated with late-onset AD. One of the strongest genetic risk factors for AD is 𝜀4 allele of APOE encoding apolipoprotein (ApoE), which is predominantly expressed in glial cells. One of the overarching questions is whether and how this astrocyte-enriched risk factor initiates AD-associated pathology in neurons such as Aβ accumulation and neurodegeneration. Here, we use human induced pluripotent stem cells (hiPSCs) from healthy individuals and isogenic cells in which the ApoE 𝜀3 allele was replaced with an 𝜀4 allele to generate human neurons and astrocytes. We then investigate the effect of astrocytic ApoE4 on the neuronal Aβ production. We find that secretory factors in conditioned media from hiPSC-derived astrocytes carrying APOE4 significantly increased the levels of APP and Aβ secretion in hiPSC-derived neurons. Increasing cholesterol levels in culture media mimicked the effects of ApoE4 ACM by inducing the formation of lipid rafts that potentially provide a physical platform for APP localization on the membrane. We further found that reducing cholesterol levels in ApoE4 ACM with MβCD abolished its effects on neuronal lipid raft expansion and Aβ generation. Our study suggests that ApoE4 astrocytes contribute to amyloidosis by the expansion of lipid rafts and facilitate neuronal Ab production through oversupply of cholesterol.
Application of Tennessee Value-Added Assessment System in The Quality Management of Clinical Bedside Teaching Base
Authors: Jiang Qingyu , Wu Yuanxi , Liu Yingchao 
Published: December 2020

Abstract
Background: Compared with foreign countries, China's education evaluation system mostly adopts the method of simple comparison of students' average scores, and the evaluation results are relatively simple; It is a top-down, one-way and appraisal evaluation system, which not only can not form information feedback network, but also can not fully mobilize the enthusiasm and initiative of the evaluation subject and the evaluation object. As a value-added evaluation model, TVAAS can provide multi-dimensional information and has been widely used in foreign countries. Therefore, we need to learn from the Tennessee value-added evaluation model system, and a series of domestic studies have proved that value-added evaluation should be an important part of school evaluation. Results: The evaluation indexes of grade 2016 students were significantly better than that of grade 2015 students, and there was statistical differences between the two groups’ evaluation indexes (P < 0.05). Conclusion: To a certain extent, "Tennessee Value-Added Assessment System" can objectively evaluate the growth rate of teaching quality of clinical bedside teaching bases, and evaluate the correlation between relevant education reform measures and teaching quality improvement scientifically, which is proposed for further popularization and application.
Broad Auto-Reactive IgM Responses Are Common In Critically Ill COVID-19 Patients.
Authors: Maier Cheryl , Wong Andrew , Woodhouse Isaac , Schneider Frank , Kulpa Deanna , Silvestri Guido 
Published: December 2020

Abstract
The pathogenesis of severe COVID-19 remains poorly understood. While several studies suggest that immune dysregulation plays a central role, the key mediators of this process are yet to be defined. Here, we demonstrate that plasma from a high proportion (77%) of critically ill COVID-19 patients, but not healthy controls, contains broadly auto-reactive immunoglobulin M (IgM), and only infrequently auto-reactive IgG or IgA. Importantly, these auto-IgM preferentially recognize primary human lung cells in vitro, including pulmonary endothelial and epithelial cells. By using a combination of flow cytometry, LDH-release assays, and analytical proteome microarray technology, we identified high-affinity, complement-fixing, auto-reactive IgM directed against 263 candidate auto-antigens, including numerous molecules preferentially expressed on cellular membranes in pulmonary, vascular, gastrointestinal, and renal tissues. These findings suggest that broad IgM-mediated autoimmune reactivity may be involved in the pathogenesis of severe COVID-19, thereby identifying a potential target for novel therapeutic interventions.
All-inorganic perovskite quantum dot light-emitting memories
Authors: Lee Ya-Ju , Liu Kang-Hsiang , Peng Yi , Yen Meng-Cheng , Leng Junfu , Chang Chun-Chieh , Tamada Kaoru 
Published: December 2020

Abstract
Field-induced ionic motions in all-inorganic CsPbBr3 perovskite quantum dots (QDs) strongly dictate not only their electro-optical characteristics but also the ultimate device performance of the CsPbBr3 optoelectronics. Novel device concepts with multiple functionalities can as a result be achieved based on CsPbBr3 by carefully controlling the ionic flow under different bias conditions. Here, we show that by manipulating the ion migrations in two nominally identical, series-connected Ag/CsPbBr3/ITO devices, one device can operate as a resistive random-access memory (RRAM) while the other simultaneously as a light-emitting electrochemical cell (LEC), or vice versa, simply through the polarity switching of the external bias across the entire structure. We further show that this electrically switchable, series-connected perovskite memories and light emitters can be employed as a novel all-perovskite light-emitting memory (LEM) device for simultaneous electronic and optical reading of the encoded information in communication and computation applications. We present a physical picture that clearly depicts the movements of each ionic species and their reduction or oxidation processes in the perovskite LEM responsible for the observed electronic and optical characteristics. The demonstrated bifunctionality of the simple metal-perovskite-metal structures and the novel device concept derived from their creative synergy opens up a completely new horizon for more advanced all-inorganic perovskite optoelectronics with novel functionalities.