bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kreativitas Generasi Pesona Indonesia (Genpi) Yogyakarta dalam Mempromosikan Destinasi Digital, Studi Kasus Pasar Ngingrong Gunungkidul
Authors: Musthofa Budiman Mahmud 
Published: April 2020

Abstract Generasi Pesona Indonesia (GenPI) is a community that was inaugurated by the Ministry of Tourism of the Republic of Indonesia in 2016 as an effort in the promotion and development of Indonesian tourism through a digital platform. GenPI is spread in various regions in Indonesia, one of which is in Jogjakarta. This study aims to find out the creativity of the GenPI Yogyakarta in promoting tourism destination, especially the Digital Destinations of “Pasar Ngingrong”, Gunungkidul, Yogyakarta. The method used in this study is a qualitative method with a case study. The results showed that creativity GenPI Jogja in promoting the Digital Destinations of “Pasar Ngingrong” was carried out using social media through the four stages of the promotion, which starts from the process of determining the content, content retrieval, content editing and uploading to social media. GenPI's promotional creativity has succeeded in increasing the number of tourists, helping to advance the digital destination of “Pasar Ngingrong” and providing various positive impacts for digital destination management, Government, and local communities. Keywords: GenPI, Promotion, Digital Destinations, Pasar Ngingrong
As fricativas posteriores: caracterização articulatória e acústica do /r/ em onset silábico
Authors: Haupt Carine , Seara Izabel 
Published: April 2020

O presente estudo é um esboço inicial da caracterização articulatória e acústica de fricativas posteriores na posição de onset silábico. São poucos os estudos que utilizam recursos, como parâmetros acústicos, para confirmar as impressões de oitiva da produção das fricativas posteriores (SILVA, 2002; REINECKE, 2006; RENNICKE, 2015). Assim, este trabalho tem o objetivo de apresentar características articulatórias de fricativas posteriores a partir de imagens ultrassonográficas e, posteriormente, discutir dois parâmetros acústicos: picos espectrais e amplitude. A amostra se constitui da gravação de vídeos ultrassonográficos da produção de fricativas por duas informantes da cidade de Florianópolis. O corpus contém palavras reais e pseudopalavras, nas quais foi controlado o contexto vocálico ([a, i, u]). Para as análises, foram utilizados o software Articulate Assistant Advanced, a partir do qual foram observados os movimentos da língua em cada fricativa produzida; e o Praat, para as análises acústicas. Os resultados das imagens mostram constrições na região velar e faringal, condicionadas às vogais adjacentes: fricativas velares e faringais ocorreram apenas em contexto de [a], enquanto, para os demais contextos, foram encontradas fricativas glotais. Em nossos dados, a amplitude se mostrou um parâmetro significativo para distinguir as fricativas posteriores, e os picos espectrais encontram-se em frequências mais altas para as velares do que para as faringais e seguem o padrão das vogais para as glotais. Todavia, consideramos necessários mais estudos para maiores generalizações.
Caracterización de lidocaína y articaína mediante técnica troncular en exodoncias de terceros molares inferiores incluidos
Authors: Baeza Solange , Leiton Emilio , Zárate Nicole 
Published: April 2020

Objetivo: Caracterizar los efectos de tiempo de latencia, tiempo de profundidad y tiempo de duración total de articaína al 4% y lidocaína 2% ambas con epinefrina 1:100.000, mediante técnica troncular para la exodoncia con odontosección de terceros molares inferiores incluidos. Materiales y Métodos: Se realizó un estudio descriptivo de tipo de serie de casos transversal seleccionada por un muestreo no probabilístico por conveniencia de 27 sujetos, con terceros molares inferiores incluidos con necesidad de odontosección donde durante el procedimiento hayan utilizado Articaína 4% o Lidocaína al 2%, ambas con epinefrina 1:100.000. Se recopilaron datos en relación al procedimiento. Resultados: El tiempo total de duración del efecto anestésico fue mayor con el uso articaína al 4% versus lidocaína 2%, siendo esto estadísticamente significativo, no así en el tiempo de latencia y el tiempo de profundidad anestésica que no presentaron significancia estadística. Conclusión: La articaína al 4% presenta el mejor tiempo de duración total del efecto anestésico, por lo que sería preferente para procedimientos de larga duración, permitiendo mayor comodidad post-operatoria.
Evaluación instrumental colorimétrica de resinas compuestas que imitan dentina en comparación a escala vita clásica
Authors: Sarmiento Jaime , Morales Jessie , Hidalgo Leslie , Leiva Ivan 
Published: April 2020

Objetivos: Determinar cuantitativamente en 7 marcas comerciales diferentes de resinas compuestas que simulan dentina (Filtek Z350XT® 3M ESPE ™, Miris 2® Coltène™, Empress Direct® Ivoclar Vivadent ™, Opallis® FGM™, TPH Spectra® DentsplySirona ™ Tetric N Ceram® Ivoclar Vivadent™, Brilliant Everglow® Coltène ™) codificado como Vita Clásica Vita Zahnfabrik™) A2 y A3 o un tinte equivalente, la diferencia de color (ΔE) con la escala Vita Classic para esa codificación en un fondo blanco o negro. Materiales y métodos: Estudio descriptivo in vitro. Se utilizaron 7 marcas de resinas compuestas (N 35) en tonos A3 y A2, se realizaron discos de 10 mm de diámetro y 2 mm de grosor, medidos con espectrofotometría en 2 fondos con instrumento Vita Easyshade V® Vita Zahnfabrik™. Se analizaron los valores obtenidos en CIELAB obteniendo ΔE. Se realizó una prueba ANOVA 2 factores (a0,05). Resultados: El ΔE más cercano a la escala Vita Clásica® fue dado por TPH Spectra® DentsplySirona™ A2 (1.02 ±.69), el ΔE mayor fue de Filtek Z350XT® 3M ESPE™ (69.31±.50).Conclusión: Existen claras diferencias entre las resinas de las marcas comerciales estudiadas y la escala Vita Clásica. En fondo negro un 71,4% de todas las muestras y en fondo blanco un 92,8% están sobre un ΔE 5, significando que las diferencias entre sus tintes son consideradas inaceptables clínicamente. Ninguna de las marcas de resinas compuestas cumple con las características colorimétricas al compararlas con la escala Vita Clásica.
Acadêmicos de Odontologia e o diagnóstico das lesões bucais: um estudo piloto
Authors: Rados Pantelis Varvaki , Barbachan João Jorge Diniz , Sant'Ana Filho Manoel , Cattelan Caren Rosane 
Published: April 2020

Este trabalho foi realizado para esclarecer algumas dúvidas surgidas no departamento de Patologia da FO-UFRGS. O nosso questionamento se fundamenta na observação do baixo número de exames histopatológicos requeridos pelos alunos desta instituição, apesar do número siginficativo de pacientes que estes atendem nesta mesma faculdade. Este fato nos remete a uma discordância com a literatura, pois esta apresenta índices razoáveis de lesão por paciente, bem maiores dos que os apresentados a nós. Realizou-se, então, esta pesquisa junto à uma amostra aleatória de alunos que prestavam atendimento no ambulatório da faculdade, avaliando a conduta clínica dos mesmos no que se referia a o diagnóstico de lesões presentes.
Nossos resultados não foram distantes dos apresentados pela literatura, demonstrando a existência de falhas na abordagem do paciente por parte do aluno, no que diz respeito ao exame clínico.
Enxerto ósseo para atrofia de mandíbula
Authors: Beltrão Gilson Correa , Zardo Mauricio , Raffin Rosane 
Published: April 2020

A atrofia da mandíbula desdentada é, na verdade, um desafio para os protesistas. A dificuldade de copiar as nuanças do rebordo e de confeccionar um aparelho protético estável, nestes casos, é enorme.
No presente trabalho, procuramos demonstrar, através de descrição de um caso clínico, os recursos que a cirurgia, enxerto de crista ilíaca, proprociona como fim. Possibilitando um aumento de rebordo, bem como acidentes anatômicos mais nítidos. Desta forma, procura o protesista desenvolver o seu trabalho com adequada estabilidade.
ÓRGÃOS DE JUVENTUDE NOS ESTADOS DO MARANHÃO, MATO GROSSO DO SUL E RIO GRANDE DO NORTE
Authors: Jardim Andreia Crystina Silva , Souza Melquisedeque Santana de , Souza João Mateus Lima de , Alves Pedro Henrique dos Santos , Shintaku Milton 
Published: April 2020

A estrutura brasileira formada pelas esfera federal, estadual e municipal descentraliza ações, compartilhando o poder, mas requerendo articulação entre as esferas. Nesse sentido, requer conhecimento de todos os órgãos que atuam em um tema, como a juventude, que possui um órgão federal: a Secretaria Nacional de Juventude (SNJ). Nesse sentido, o presente estudo tem por objetivo levantar as unidades de juventude municipais nos estados do Maranhão, Mato Grosso de Sul e Rio Grande do Norte, a fim de criar uma amostra do cenário nacional sobre essas unidades. Um estudo misto, com coleta de dados efetuada nos estados, verificou que os estados possuem órgãos de juventude, mas nem todos municípios desses estados possuem. Da mesma forma, podem-se apresentar indícios de que o tamanho da população não é um fator preponderante para ter ou não unidade de juventude nas cidades brasileiras. Assim, a presente análise procura apoiar estudos sobre a organização políticas dos municípios brasileiros, apresentando uma amostra do cenário sobre a presença das unidades de juventude nas cidades dos estados do Maranhão, Mato Grosso de Sul e Rio Grande do Norte
Catechin-based Dentin Pretreatment and the Clinical Performance of a Universal Adhesive: A Two-year Randomized Clinical Trial
Authors: Costa CAGA , Albuquerque NLG , Mendonça JS , Loguercio AD , Saboia VPA , Santiago SL 
Published: April 2020

Clinical Relevance
At 24 months, the dentin pretreatment with epigallocatechin-3-gallate did not impair the clinical performance of the adhesive Single Bond Universal regardless of the bonding strategy used.

SUMMARY
Purpose: To evaluate the two-year effect of dentin pretreatment with epigallocatechin-3-gallate (EGCG) on the clinical performance of restorations of noncarious cervical lesions (NCCLs) with Single Bond Universal, applied in two different modes (self-etch and etch-and-rinse).
Methods and Materials: In this randomized clinical trial, 33 volunteers were selected, and 156 NCCLs were assigned to four groups: ER, etch-and-rinse; ER-EGCG, 0.1% EGCG dentin pretreatment + etch-and-rinse; SE, self-etch; and SE-EGCG, 0.1% EGCG dentin pretreatment + self-etch. The NCCLs were restored with a nanofilled resin composite and evaluated at baseline and at six, 12, 18, and 24 months using FDI criteria for retention, marginal staining, marginal adaptation, caries, and postoperative sensitivity. Two evaluators were blinded to the treatments performed, and impressions were taken for resin replicas to allow indirect observations. Statistical analyses were performed with Kruskal-Wallis and McNemar tests with a significance level of 5%.
Results: Six restorations (one from ER, two from SE, one from ER-EGCG, and two from SEEGCG) were lost at 24 months with no significant differences (p&gt;0.05). The retention rates were 97.0% (ER and ER-EGCG), 94.1% (SE), and 94.2% (SE-EGCG). For marginal adaptation, a significant difference was detected between the baseline and 24 months for the SE group (p=0.0313). There were no statistical differences among all other evaluated criteria at 24 months, neither for each group at baseline nor for 24-month comparisons (p&gt;0.05).
Conclusions: The pretreatment with EGCG provided no benefit in the clinical performance of the adhesive regardless of the bonding strategy used. In addition, it adds an additional required step to the restorative procedure.
Assessing the Nutritional Condition of The Elderly: Perspectives of Trained Health Workers and Significant Others in Countryside in Indonesia Inputs to an Action Plan
Authors: Winandari Fransisca 
Published: April 2020

Background: Nutrition plays an important role in health maintenance, rehabilitation, and prevention and control of disease for the elderly. If undetected, nutritional problems among the elderly may result in more rapid deterioration of health and early death. Methods: In this study, the researcher conducted descriptive correlational design to describe the perspectives of trained health workers and significant others on the nutritional condition of the elderly in terms of nutritional screening, nutritional assessment, and nutritional indication score. Results: The population of this study is the trained health workers in Bambanglipuro and the significant others of the elderly who met the inclusion criteria. There are 50 of trained health worker respondents and 112 significant other respondents. Their assessment was assessed by themselves and tested significant differences using the T-test. All the computed t values were less than T values of 1.96. This result shows that the null hypothesis is accepted, meaning there is no significant difference between the assessment of the trained health worker respondents and the significant other respondents on the nutritional condition of the elderly. It proved that the significant others completely knew about the nutritional condition of the elderly.Conclusions: Proposed action plan can be applied for enhancement of the nutritional condition of the elderly, such as to conduct a lecture related to the importance of assessing the physical problems of the patient, conduct a lecture related to the importance of assessing the patient’s mode feeding, conduct a training workshop related how to measure Calf Circumference and Mid-arm Circumference (MAC).
Toxicological properties of Δ9-tetrahydrocannabinol and cannabidiol
Authors: Černe Katarina 
Published: April 2020

Abstract

Cannabis sativa L. contains more than 100 phytocannabinoids that can interact with cannabinoid receptors CB1 and CB2. None of the cannabinoid receptor ligands is entirely CB1- or CB2-specific. The effects of cannabinoids therefore differ not just because of different potency at cannabinoid receptors but also because they can interact with other non-CB1 and non-CB2 targets, such as TRPV1, GPR55, and GPR119. The most studied phytocannabinoid is Δ9-tetrahydrocannabinol (THC). THC is a partial agonist at both cannabinoid receptors, but its psychotomimetic effect is produced primarily via activation of the CB1 receptor, which is strongly expressed in the central nervous system, with the noteworthy exception of the brain stem. Although acute cognitive and other effects of THC are well known, the risk of irreversible neuropsychological effects of THC needs further research to elucidate the association. Unlike THC, phytocannabinoid cannabidiol (CBD) does not appear to have psychotomimetic effects but may interact with some of the effects of THC if taken concomitantly. CBD administered orally has recently undergone well-controlled clinical trials to assess its safety in the treatment of paediatric epilepsy syndromes. Their findings point to increased transaminase levels as a safety issue that calls for postmarketing surveillance for liver toxicity. The aim of this review is to summarise what is known about acute and chronic toxicological effects of both compounds and address the gaps in knowledge about the safety of exogenous cannabinoids that are still open.
A regulatory take on cannabis and cannabinoids for medicinal use in the European Union
Authors: Lipnik-Štangelj Metoda , Razinger Barbara 
Published: April 2020

Abstract
The discovery of the endocannabinoid system has raised public interest in the medicinal use of cannabis, phytocannabinoids, and synthetic cannabinoids, which has always been closely regulated due to their psychotropic effects and potential abuse. The review takes a quick look at the current legal framework in the European Union, which regulates cannabis use and cultivation for medicinal purposes in line with the United Nations Conventions on the production, trade, and use of cannabis, phytocannabinoids, and synthetic cannabinoids. And while the EU legislation precisely defines requirements and marketing authorisation procedures for medicinal products for all EU member states, there is no common regulatory framework for magistral and officinal preparations containing cannabinoids, as they are exempt from marketing authorisation. Instead, their regulation is left to each member state, and it is quite uneven at this point, mainly due to cultural and historical differences between the countries, leading to different access to non-authorised medicinal products. Therefore, to meet great public interest, harmonised approaches on cannabinoid-containing products without marketing authorisation would be welcome to level the playing field in the EU.
Reproductive disorders in male rats induced by high-fructose consumption from juvenile age to puberty
Authors: Tkachenko Oleksandr Y. , Shayakhmetova Ganna M. , Matvienko Anatoliy V. , Kovalenko Valentina M. 
Published: April 2020

Abstract
There is compelling evidence that a hypercaloric, high-fructose diet can cause metabolic syndrome (MetS) and a whole range of other metabolic changes. In the context of androgen deficiency, MetS in boys merits special attention, but the effects of fructose-rich diet in youth on future male reproductive function are still poorly evidenced. The aim of this study was to address this issue and analyse the effects of high-fructose intake starting from weaning to puberty (postnatal day 23 up to 83) on the reproductive function of male rats. For this purpose juvenile male Wistar rats were divided in two groups: control and the group receiving 10 % fructose solution instead of drinking water. Reproductive function was evaluated in terms of fertility, sperm count, testes/epididymis morphology, and serum sex hormones. The fructose-treated group showed a decrease in testosterone and twofold increase in luteinising and follicle-stimulating hormone levels in the serum. This was accompanied with lower testis/epididymis weights, sperm count, and changed testis/epididymis morphology. Their fertility remained unchanged, but the fertility of females mating with these males diminished. In addition, pre-implantation and post-implantation embryonic death rate rose in these females. Our results have confirmed that high fructose consumption from early age until puberty can impair the reproductive function of male rats, and call for further animal and epidemiological investigation.
Effect of urine adulterants on commercial drug abuse screening test strip results
Authors: Rajšić Ivana , Javorac Dragana , Tatović Simona , Repić Aleksandra , Đukić-Ćosić Danijela , Đorđević Snežana , Lukić Vera , Bulat Zorica 
Published: April 2020

Abstract
Immunochromatographic strips for urine drug screening tests (UDSTs) are common and very suitable for drug abuse monitoring, but are also highly susceptible to adulterants kept in the household, which can significantly alter test results. The aim of this study was to see how some of these common adulterants affect UDST results in practice and whether they can be detected by sample validity tests with pH and URIT 11G test strips. To this end we added household chemicals (acids, alkalis, oxidizing agents, surfactants, and miscellaneous substances) to urine samples positive for amphetamine, 3,4-methylenedioxymethamphetamine (MDMA), tetrahydrocannabinol, heroin, cocaine, or benzodiazepines (diazepam or alprazolam) and tested them with one-component immunochromatographic UDST strips. The UDST for cocaine resisted adulteration the most, while the cannabis test produced the most false negative results. The most potent adulterant that barely changed the physiological properties of urine specimens and therefore escaped adulteration detection was vinegar. Besides lemon juice, it produced the most false negative test results. In conclusion, some urine adulterants, such as vinegar, could pass urine specimen validity test and remain undetected by laboratory testing. Our findings raise concern about this issue of preventing urine tampering and call for better control at sampling, privacy concerns notwithstanding, and better sample validity tests.
Soft nanotechnology: the potential of polyelectrolyte multilayers against E. coli adhesion to surfaces
Authors: Fink Rok , Oder Martina , Jukić Jasmina , Cindro Nikola , Požar Josip 
Published: April 2020

Abstract
Preventing bacterial attachment to surfaces is the most efficient approach to controlling biofilm proliferation. The aim of this study was to compare anti-adhesion potentials of 5 and 50 mmol/L polyelectrolyte multilayers of poly(allylamine hydrochloride)/poly(sodium 4–styrenesulfonate), poly(4-vinyl-N-ethylpyridinium bromide)/ poly(sodium 4–styrenesulfonate), and poly(4-vinyl-N-isobutylpyridinium bromide)/poly(sodium 4–styrenesulfonate) against Escherichia coli. Glass surface was covered with five polyelectrolyte layers and exposed to bacterial suspensions. Poly(4-vinyl-N-ethylpyridinium bromide)/poly(sodium 4–styrenesulfonate) was the most effective against bacterial adhesion, having reduced it by 60 %, followed by poly(4-vinyl-N-isobutylpyridinium bromide)/poly(sodium 4– styrenesulfonate) (47 %), and poly(allylamine hydrochloride)/poly(sodium 4–styrenesulfonate) (38 %). Polyelectrolyte multilayers with quaternary amine groups have a significant anti-adhesion potential and could find their place in coatings for food, pharmaceutical, and medical industry.
Cytotoxic and mutagenic potential of juglone: a comparison of free and nano-encapsulated form
Authors: Erisen Semiha , Arasoğlu Tülin , Mansuroglu Banu , Kocacaliskan İsmail , Derman Serap 
Published: April 2020

Abstract
Despite its evidenced beneficial herbicidal, antibacterial, antiviral, antifungal, and antioxidant effects, the application of juglone (5-hydroxy-1,4,-naphthoquinone) is limited due to its low water solubility and allelopathic and toxic effects. In recent years, research has aimed to overcome these limitations by increasing its solubility and controlling its release through nanoparticular systems. This is the first study to have synthesised and characterised juglone-loaded polymeric nanoparticles and compared them with free juglone for cytotoxicity in mouse (L929 fibroblasts) and alfalfa cells and for mutagenic potential in Salmonella typhimurium TA98/100. Mouse and plant cells treated with free and nano-encapsulated juglone showed a decrease in cell viability in a dose and time-dependent manner, but this effect was significantly lower with the nano-encapsulated form at lower doses. In the TA98 strain with S9, nano-encapsulated juglone did not exhibit mutagenic effects, unlike the free form. Since all results show that juglone encapsulation with polymeric nanoparticles reduced the toxic and mutagenic effects, it has a promising potential to be applied in medicine, food safety, and agriculture.