bluuebunny/crossref_metadata_2025_split huggingface dataset:
How the Content of Interprofessional Safety Management Education Can Be Structured Through the Perception of Nursing Home Practitioners: A Mixed Methods Design
Authors: Hong You Jung , Kim Dayeong , Chang Sung Ok 
Published: December 2024

ABSTRACTAimThis study aimed to assess perceptions of safety management, with a particular focus on interprofessional influences, to determine priorities for safety management training needs and to explore target areas for strengthening the capacity of nursing home practitioners.DesignA mixed methods design was used.MethodsA qualitative‐driven mixed methods design was employed in two phases. In Phase 1, as a core component for integrating supplementary components, an inductive content analysis was performed to investigate perceptions of safety management and specific aspects of care related to it through semi‐structured interviews with nursing home practitioners. In Phase 2, a descriptive survey was conducted using items derived from the interviews conducted in the initial stage. The aim was to explore the educational needs of practitioners concerning safety management elements practised in nursing homes.ResultsIn the study, through qualitative interviews, practitioners' perceptions of interprofessional safety management were derived into 5 themes and 22 subthemes. Based on this, the results of a descriptive survey derived priorities through a paired t‐test, importance‐performance analysis, Borich's needs assessment model and the Locus for Focus model for safety management items performed by nursing home practitioners. Results from both phases of the study showed that practitioners recognise the importance of sharing the causes of safety accidents and that there is a high need for training on falls, dehydration, and hypoglycaemia management.Patient or Public ContributionNurses, care workers, physical therapists, and social workers employed in nursing homes took part in this study by participating in interviews and surveys.
The Landscape of Pediatric Procedural Sedation in the United Kingdom and Irish Emergency Departments; an International Survey Study
Authors: Hall Dani , Moriarty Tadgh , Roland Damian , O'Sullivan Ronan , Blackburn Carol , Hartshorn Stuart , Messahel Shrouk , Lyttle Mark D. ,   PERUKI
Published: December 2024

ABSTRACTApproximately 250 000 children undergo pediatric procedural sedation (PPS) in Emergency Departments (ED) in the United Kingdom and Ireland annually. PPS practice in our setting has not been described as fully as other high‐income countries. We aimed to evaluate PPS in EDs in the United Kingdom and Ireland. An online survey was distributed through Paediatric Emergency Research in the UK and Ireland (PERUKI), in June 2020. One respondent per ED completed the survey, including questions on agents, fasting, training, and governance. Of 72 PERUKI sites, 61 (85%) responded, of which PPS was performed in 50 (82%). Internal training packages existed in under half (22/50, 44.0%). Most had a guideline (43/50; 86.0%) and documentation proforma (39/50; 78.0%). Audit databases existed in 24/50 (48.0%). Intravenous ketamine was the most common agent (43/50; 86%), followed by variable concentration nitrous oxide (13/50; 26%). Fasting practices varied widely across sites and agents. We have demonstrated widespread PPS use, but non‐standardized practice. This leads to potential issues of risk and variability across agents, highlighting a need for a sedation package in the United Kingdom and Ireland to standardize practice and data collection. We propose development of a prospective ED sedation registry in the United Kingdom and Ireland to facilitate data collection to support research within this area.
A Novel Schiff Base Epoxy: Synthesis, Degradability, and Application as a MultiPurpose Modifier for DGEBA/DDM
Authors: Gao Chenchen , Xing An , He Zhiqi , Yuan Peichen , Qiao Yajing , Li Xiaoyu 
Published: December 2024

ABSTRACTSimultaneously increasing mechanical strength, toughness, thermal stability, and flame retardancy of epoxy thermoset without compromising transparency is appealing but challenging. To address that goal, a Schiff base epoxy VDEP is developed. The neat VDEP‐cured product, VDEP100wt%, not only shows comparable mechanical strength to conventional epoxy thermoset but also can be degraded in 10% H2SO4/THF/H2O solution in 24 h, showing great degradability under mild conditions. More importantly, proper addition of VDEP simultaneously increases the tensile strength, impact strength, T
g, T
d5%, char residue, and UV shielding of cured epoxies while providing self‐extinguishing ability. All of those enhancements are achieved without deteriorating transparency. When 15 wt% of VDEP is added, the tensile strength reaches 91.07 MPa, with a 36.7% increase; the impact strength reaches 40.73 kJ m−2, with a 33.8% increase. The enhancement in mechanical strength is due to the reinforcing effect of intermolecular interaction and compacted network caused by free volume reduction. The higher toughness results from greater mobility of chain segments, reduced crosslinking density and energy dissipative intermolecular interaction. The rigid two benzene‐conjugated Schiff base structure and abundant hydrogen bonding contribute to higher T
g. Therefore, this work provides a degradable Schiff base epoxy and high‐performance thermoset based on it.
Short‐Term Effectiveness of a Stepped‐Care Model to Address Fear of Cancer Recurrence in Patients With Early‐Stage Melanoma
Authors: Thompson Jake R. , Gomes Lisa , Kouvelis Grace , Smith Andrea L. , Lo Serigne N. , Kasparian Nadine A. , Saw Robyn P. M. , Dieng Mbathio , Seaman Linda , Martin Linda K. , Guitera Pascale , Milne Donna , Schmid Helen , Cust Anne E. , Bartula Iris 
Published: December 2024

ABSTRACTObjectiveTo investigate the effectiveness of the Melanoma Care Programme when implemented into routine clinical practice coupled with fear of cancer recurrence (FCR) screening and a stepped‐care model of intervention delivery.MethodsUsing a Type‐I hybrid effectiveness‐implementation design, individuals with stage 0‐II melanoma and a Fear of Cancer Recurrence Inventory FCR severity score of ≥ 13 were offered the Melanoma Care Programme. The programme included a psychoeducational booklet and 3 to 5 psychotherapeutic telehealth sessions with a clinical psychologist, timed around routine dermatological appointments. Multivariable linear mixed modelling was used to analyse the effect of the intervention at 1‐week post‐intervention on patient‐reported outcomes, including FCR severity (primary outcome), symptoms of depression, anxiety, and stress, melanoma‐related knowledge, and health‐related quality of life.ResultsOne hundred and twelve participants completed the intervention from 146 participants screened for FCR. Adjusted multivariable linear mixed modelling demonstrated that participants who received the intervention reported a reduced FCR severity at 1‐week post‐intervention (mean change: −3.81 [95% CI: −4.67, −2.95], p < 0.001) compared to baseline. Participants also reported improvements in melanoma‐related knowledge (mean change: 0.64 [95% CI: 0.13, 1.15], p = 0.014), depressive symptoms (mean change: −1.41 [95% CI: −1.92, −0.90], p < 0.001), anxiety (mean change: −1.05 [95% CI: −1.48, −0.61], p < 0.001), stress (mean change: −1.58 [95% CI: −2.22, −0.93], p < 0.001), and health‐related quality of life (mean change: 4.05 [95% CI: 2.84, 5.26], p < 0.001).ConclusionsThe Melanoma Care Programme maintained effectiveness when implemented into routine clinical practice with the addition of FCR screening and a stepped care model of delivery.Trial RegistrationThis study is registered with the Australia and New Zealand Clinical Trials Register (ACTRN12621000145808)
Identification of Gene‐Therapy Responsive Blood Biomarkers in mdx Mouse Model
Authors: Johansson Camilla , Boehler Jessica F. , Brown Kristy J. , Koeks Zaïda , Schrama Esther J. , van de Velde Nienke , Verschuuren Jan J. G. M. , Niks Erik H. , Spitali Pietro , Al‐Khalili Szigyarto Cristina 
Published: December 2024

ABSTRACTIntroductionIdentifying serum biomarkers that reflect the restoration of dystrophin in skeletal muscle is important for evaluating the effect of dystrophin‐restoring therapies in preclinical and clinical trials. Many potential blood biomarkers have been identified in Duchenne muscular dystrophy (DMD) patients, which change with disease progression or respond to pharmacological treatment. In this study, it was suggested that a panel of such blood biomarker candidates could be used to monitor dystrophin rescue in mdx mice treated with microdystrophin based therapies.MethodsPlasma samples from mdx mice treated with the microdystrophin therapy SGT‐001 were analysed with an antibody suspension bead array consisting of 87 antibodies. The array targets 83 unique proteins previously identified as biomarker candidates for DMD. Each sample was assayed at two different plasma dilutions to cover a broader concentration range. Protein concentrations estimated as Median fluorescent intensities (MFI) were correlated to dystrophin expression in muscle tissue, as measured by immunohistochemistry and Western blot. Thirteen of the targets were selected and analysed in a DMD and Becker muscular dystrophy (BMD) longitudinal natural history cohort using a suspension bead array.ResultsTen proteins were found to be significantly elevated in untreated mdx mice compared with C57 wild‐type mice and to correlate with dystrophin expression (Spearman's correlation, FDR < 0.05) upon gene transfer in mdx mice. Translatability of these biomarkers from animal models to patients was evaluated by exploring abundance trajectories over time in both DMD and BMD patients and association with dystrophin expression in BMD patients. Consistent with the observations in mouse, six of these biomarker candidates were more abundant in DMD patients compared with controls, and six were also differentially abundant between BMD and DMD patients. Among them, serum titin was shown to be associated with dystrophin expression in BMD patients, having a steeper decline over time in patients with low dystrophin expression in tibialis anterior compared with patients with high expression. Myosine light chain 3 had a steeper decline with time in DMD patients compared with BMD patients.ConclusionsThe 10 biomarker candidates identified in mouse plasma are related to muscle contraction, glycolysis, microtubule formation and protein degradation. Human titin and myosine light chain 3 were the most interesting candidates as explorative biomarkers to monitor microdystrophin expression in gene therapies. If confirmed, these biomarkers could be used to detect restoration of dystrophin expression per se, monitor changes in dystrophin expression over time and potentially confirm disease phenotype changes from severe to mild disease forms.
Organic Manganese Halides with Near‐Unity Quantum Efficiency for High‐Resolution and Flexible X‐Ray Detection and Imaging
Authors: Fan Jiali , Tong Hua , Zhou Zhennan , Lv Yi , Li Haibo , Liu Wei , Ouyang Gangfeng 
Published: December 2024

AbstractIn this paper, two new organic manganese halides (pe‐ted)2MnX4 (pe‐ted+ = ethylphenyltriethylenediamine cation, X = Cl, Br) are synthesized, exhibiting green luminescence with near‐unity photoluminescence quantum efficiency. (pe‐ted)2MnBr4 shows good linear response to X‐ray dose rate, with a high light yield of ≈62 000 photons MeV−1 and low detection limit of 1.376 µGy s−1. Flexible scintillator film is prepared by blending with polydimethylsiloxane for high‐resolution imaging, with a low detection limit (5.173 µGy s−1), an excellent X‐ray imaging spatial resolution (18.0 lp mm−1) and an impressive X‐ray irradiation switching stability (3.6 mGy s−1). WLED of high color rendering index has also been fabricated. These findings represent an example of shapeable X‐ray scintillators, providing new possibilities for curved and 3D X‐ray imaging.
Efficient Storage of Sodium Based on MnSe@MoS2 Heterostructure With “Stress–Strain Transfer” Mechanism for Sodium‐Ion Batteries
Authors: Xu Ruixiang , Wang Liying , Yang Xijia , Li Xuesong , Jiang Yi , Lü Wei 
Published: December 2024

Abstract2D layered embedding materials have shown promising applications in rapidly rechargeable sodium‐ion batteries (SIBs). However, the most commonly used embedding structures are susceptible to damage and collapse with increasing cycles, which in turn leads to a degradation of the overall performance of the batteries. In order to address this issue, a “stress‐strain transition” mechanism is proposed to form a heterostructure by introducing pyramid‐like MnSe into the MoS2 lattice to reduce the irreversible reconstruction under deep discharge. Density functional theory and Finite element method simulation reveal that the strong orbital coupling of Mn–Mo at the heterogeneous interface provides a guarantee for the directional migration of ions, alleviates the lattice expansion caused by embedding strain, and avoids irreversible structural changes during battery operation. The capacity measured at 0.1C is 612 mAh g−1, which is consistent with the theoretical prediction. The experimental results demonstrate that the capacity is maintained at 80.3% of the initial value after 3500 cycles. This work demonstrates a strategy of addressing the structural collapse of 2D layered materials and paves the way for the commercialization of SIBs.
Fragility analysis of a triangular free‐form reinforced concrete shell
Authors: Garcia Maya Sian Caycedo , Siqueira Gustavo Henrique , Vieira Junior Luiz Carlos Marcos , Cárdenas Diego Rafael Joya , Vizotto Isaias 
Published: December 2024

AbstractConsidering the importance of deepening the knowledge of the structural behavior of free‐form shell structures with a triangular plan, this work presents the results of research on the analysis of seismic vulnerability, verified through linear time‐history analysis (NLTHA), generating fragility curves through PSDM models. The analyzes carried out are based on uncertainties regarding both the mechanical properties of the materials and the geometric characteristics of the structures, as well as the action of seismic events. Real accelerograms, compatible with the elastic response spectra for Lisbon and Ouren, Portugal given by the EC8 standard, are used to consider seismic events. In the analyses, fundamental factors are considered, such as the accumulation of damage and the degradation in the resistance of materials. The structure presents highly ductile behavior in the face of seismic loads, attributed to its rigidity, geometry, lightness, and modal behavior, with participation in the horizontal components of the mass in the first five vibration modes greater than 80% and with minimal influence of the vertical component, characteristics inherent to this type of structure. However, it should be noted that the area close to the support, in the same direction as the ground acceleration, is the most vulnerable. This occurs due to the plastic yielding of the concrete during the earthquake, which promotes the appearance of cracks and compression damage. This is verified for the structure when subjected to earthquakes with PGA in the horizontal direction between 0.01 and 0.8 g. The probability of considerable damage increases with seismic events having PGA greater than 0.6 g, which, in turn, can compromise the stability of the structure. It is, therefore, of great importance to study the seismic behavior of shell structures, especially free‐form shells, considering the variability and uncertainties related to the structural stress arising from the seismic demand.
Evaluation of the Accuracy of FreeStyle Libre 2 for Glucose Monitoring in White New Zealand Rabbits
Authors: Choi Minseok , Chae Yeon , Park Jayeon , Lee Yelim , Park Kyung‐Mee , Jeong Dong‐Hyuk , Kang Byeong‐Teck , Yun Taesik , Kim Hakhyun 
Published: December 2024

ABSTRACTBackgroundStudies are currently being conducted on rabbits requiring serial glucose monitoring. The FreeStyle Libre 2 (FSL2), a serial glucose monitoring device, has been validated in humans, dogs and cats, but not in rabbits.ObjectivesThis study aimed to evaluate the accuracy of the FSL2 in rabbits.MethodsSix healthy rabbits were used in this study. Interstitial glucose (IG) was measured using the FSL2, and blood glucose (BG) was measured using a portable blood glucose meter (PBGM); their results were compared with those from a clinical chemistry analyser. For the first 3 h, IG and BG were measured at 1‐h intervals. Subsequently, they were measured every 8 h over a 48‐h period. Regular insulin 0.2 U/kg was then administered to the rabbits, and IG and BG were measured every 15 min over a 90‐min period.ResultsBefore insulin treatment, no measurements fell within the hypoglycaemic range (BG < 100 mg/dL). In the euglycaemic range (BG ≥ 100 mg/dL), the PBGM and FSL2 showed 85.7% and 23.8% accuracies, respectively. After insulin treatment, the PBGM showed 95.5% and 81.3% accuracies in the hypoglycaemic and euglycaemic ranges, respectively. The FSL2 showed 68.1% and 37.5% accuracies in the hypoglycaemic and euglycaemic ranges, respectively. Parkes consensus error grid analysis showed that the PBGM and FSL2 had 100% agreement for Zones A (no effect on clinical action) and B (altered clinical action unlikely to affect outcome) in rabbits with and without insulin treatment.ConclusionsThere was limited agreement between the FSL2 and reference standard BG measurements. However, the FSL2 allows clinically acceptable identification of hypoglycaemic states in rabbits.
Dynamic changes and prognosis value of plasma syndecan‐1 and different microcirculatory parameters in sepsis: A prospective observational study
Authors: Qian Xiayan , Lui Ka Yin , Hu Xiaoguang , Li Shuhe , Song Xiaodong , Lin Changcheng , Liang Yujun , Guan Xiangdong , Cai Changjie 
Published: December 2024

AbstractBackgroundGlycocalyx degradation is implicated in endothelial damage and microcirculatory dysfunction in sepsis, whereas the effectiveness of plasma syndecan‐1 levels and sublingual microcirculatory parameters in evaluating sepsis's prognosis has not yet been determined. This study aims to track their dynamic changes and investigate the prognostic utility of these indexes in sepsis.MethodsIn this prospective study conducted at the First Affiliated Hospital of Sun Yat‐sen University, blood samples were collected from adult surgical septic patients within 2 days after intensive care unit admission measuring plasma syndecan‐1 concentrations. Relevant sublingual microcirculatory parameters were also obtained simultaneously. Additionally, capillary refill time and serum lactate levels were recorded. The primary outcome was 30‐day mortality.ResultsOf the 74 patients enrolled, the 30‐day mortality rate was 35.1%. Significantly, higher syndecan‐1 levels were observed in nonsurvivors at baseline, day 1, and day 2 (62.43 [37.37 and 103.16] vs. 97.24 [52.95 and 186.40] ng/mL and p = 0.035; 62.22 [41.50 and 87.52] vs. 96.71 [60.82 and 176.00] ng/mL and p = 0.009; and 56.03 [39.16 and 94.48] vs. 87.69 [72.52 and 159.70] ng/mL and p = 0.005, respectively). High syndecan‐1 levels (≥121 ng/mL) were associated with lower survival rates (p = 0.001) and an increase exceeding 8 ng/mL within 2 days indicated a higher mortality risk (p = 0.0075). Syndecan‐1 levels displayed satisfactory prognostic capability (AUC: 0.7056), whereas combining syndecan‐1 and blood lactate demonstrated the highest predictive ability for 30‐day survival (AUC: 0.7726).ConclusionsPlasma syndecan‐1 levels effectively predict sepsis prognosis, with higher baseline levels or increasing trends indicating worse outcomes. Combining syndecan‐1 with blood lactate enhances predictive accuracy for 30‐day mortality in sepsis.Trial RegistrationThis study registered in China on December 31, 2021 at Chinese Clinical Trial Registry (ChiCTR2100055066).
“Let Me Tell You How I See It…”: White Women, Race, and Welfare on Two Birmingham Council Estates in the 1980s
Authors: White Jessica 
Published: December 2024

AbstractBased on 48 interviews carried out between 1983 and 1984 with White working-class women in two housing estates in Birmingham, this chapter demonstrates how these women deployed their personal experiences of welfare as the grounds for their expertise, which was used to make claims about their rights to welfare provisions, legitimate their racist beliefs, and posit new ways of “doing welfare”. I argue that White women’s experiential expertise culminated in a cultural script within which the right to “fare well” was mediated through notions of race and racial difference. In voicing their shared experiences of living in competition with their neighbours of colour, these women constructed a “community of experience”, which was defined as being both “White” and British, and having exclusive, and deserving, access to the British welfare state.
Student Voices, Expertise, and Welfare Within British Universities in the Mid-Twentieth-Century
Authors: Crook Sarah 
Published: December 2024

AbstractThe contemporary student is extensively surveyed about their experiences of university provision and their opinions about the extent to which their institutions attend to their health and welfare. This chapter looks to some of the ways that students articulated their views of university health and welfare provision in the middle decades of the twentieth century. It argues that the National Union of Students (NUS) played a crucial role in ascertaining how institutions could help students to “fare well”, and through its emphasis on its leaders’ temporal proximity to student life it emphasised experiential authority. It also argues that the growth of sociological surveys of students’ experience of welfare and health facilities in the 1960s and 1970s helped to legitimise and embed ideas about the experiential knowledge held across the student body.
Placing Experiential Expertise: The 1981 New Cross Massacre Campaign
Authors: Andrews Aaron 
Published: December 2024

AbstractOn the morning of Sunday 18 January 1981, a fire broke out at a house in New Cross, London, injuring many, and killing thirteen young Black men, women, and children. In 1983, a fourteenth name was added to the toll. The New Cross massacre, named by activists, quickly became the focal point of a campaign for truth and justice which saw up to 20,000 march across London on the Black People’s Day of Action, and which later extended to the courts. Records of the New Cross Massacre Action Committee, an umbrella organisation, were preserved and curated in an archive at the George Padmore Institute. Using the GPI archive alongside additional archival collections, contemporary newspaper reporting, and cultural artefacts, this chapter examines how bereaved families, survivors, British Black Power activists, and community organisers mobilised experiential expertise to challenge the legal and scientific expertise deployed by state institutions. In doing so, it focuses on three spaces in which experiential expertise was operationalised to improve the welfare of Black Britons: street, courts, and archive. The chapter also reflects on the positionality and ethics of academics researching traumatic experiences of minoritised and marginalised communities when academics themselves do not share those experiences.