bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparison of Multimedia and Traditional Paper Assignments in an Introductory Psychology Course
Authors: Riordan Monica A. , Abo-Zebiba Zamen , Marsh Joseph 
Published: September 2020

Background: Multimedia creation and curation for assignments have the potential to engage students in deeper learning. Objective: This study explored whether the same homework assignments delivered in paper versus multimedia format resulted in different student experiences. Method: Introductory psychology students submitted either traditional papers or multimedia projects to address the same assignment prompt, a process that was repeated seven times throughout four courses and was either instructor-determined or student-selected. Students were surveyed about the assignment formats, and assignment grades were analyzed. Results: Overall, students found the multimedia assignments more engaging, more enjoyable, more interesting, and more difficult than paper assignments. When assignments were instructor-determined, students reported higher perceived learning for the multimedia assignments. Assignment grades were not significantly different between assignment formats. Conclusion and teaching implications: These results suggest that moving traditional paper assignments into a multimedia format is a no-cost way to improve the student experience.
Examining How Students with Visual Impairments Navigate Accessible Documents
Authors: Singleton Korey J. , Neuber Kristine S. 
Published: September 2020

Introduction: This exploratory study examined how students with visual impairments navigate accessible Word and PDF documents. Methods: Using a combination of video observations and semi-structured interviews, data were collected on participants’ expressed and observed interactions with accessible Word and PDF documents. Results: Using a technique called summative content analysis, four core themes emerged from the findings: useful navigation elements or features (expressed and observed), strategies for navigating accessible documents, barriers to access, and coping strategies. Discussion: The findings suggest practical strategies for training participants to navigate accessible documents. Additionally, they identify the structural elements (i.e., headings, alternative text, etc.) most useful to the study’s participants when navigating accessible documents. Implications for practitioners: As suggested by the findings of this study, universities should implement targeted training initiatives for faculty on basic document accessibility, which could include clearly defining the accessibility features included in a document. Likewise, targeted assistive technology training for students with visual impairments on how to access these elements could increase reading efficiency and reduce cognitive load.
Effect of action observation therapy on motor function in children with cerebral palsy: a systematic review of randomized controlled trials with meta-analysis
Authors: Abdelhaleem Naglaa , Taher Samar , Mahmoud Menna , Hendawy Ahmad , Hamed Maged , Mortada Hossam , Magdy Abdullah , Raafat Ezz El-Din Moustafa , Zoukiem Ismail , Elshennawy Shorouk 
Published: September 2020

Objective: To evaluate the evidence of using Action Observation Therapy in the rehabilitation of children with Cerebral Palsy. Study design: Systematic review with meta-analysis of Randomised Controlled Trials. Methods: For the purpose of identifying relevant studies, six databases were searched from inception until July 2020. The methodological quality was assessed by Physiotherapy Evidence Database scale. The outcomes were classified within the framework of the International Classification of Functioning. A pooled meta-analysis was performed on studies that demonstrated homogeneity. Results: Twelve randomised controlled trials with 307 participants were included with six of them were included in the meta-analysis. Non-significant difference between the groups was demonstrated by meta-analysis. Results of capacity assessed in post treatment and follow up evaluation were (0.06, –0.22 to 0.34, 95% (CI); P = 0.69 and (–0.35, –0.96 to 0.27, 95% (CI); P = 0.27); respectively. Actual performance in post-treatment and follow up were (0.10, –0.22 to 0.48, 95% (CI); P = 0.62) and (0.01, –0.40 to 0.41, 95% (CI); P = 0.97); respectively. Perceived performance evaluated using (ABILHAND-KIDS) were (0.30, –0.28 to 0.89, 95% (CI); P = 0.31) and (0.15, –0.43 to 0.73, 95% (CI); P = 0.61) for post treatment and follow up; respectively. Overall effect on activity domain was (0.08, –0.11 to 0.28, 95% (CI); P = 0.86) immediately and (0.04, –0.33 to 0.26, 95% (CI); P = 0.49) at follow-up; respectively. Conclusion: No evidence of benefit had been found to draw a firm conclusion regarding the effectiveness of action observation therapy in the rehabilitation of children with cerebral palsy due to limitations in methodological quality and variations between studies.
Experiences of augmented arm rehabilitation including supported self-management after stroke: a qualitative investigation
Authors: Schnabel Stefanie , van Wijck Frederike , Bain Brenda , Barber Mark , Dall Philippa , Fleming Alexander , Kerr Andrew , Langhorne Peter , McConnachie Alex , Molloy Kathleen , Stanley Bethany , Young Heather Jane , Kidd Lisa 
Published: September 2020

Objective: To explore the experiences of stroke survivors and their carers of augmented arm rehabilitation including supported self-management in terms of its acceptability, appropriateness and relevance. Design: A qualitative design, nested within a larger, multi-centre randomized controlled feasibility trial that compared augmented arm rehabilitation starting at three or nine weeks after stroke, with usual care. Semi-structured interviews were conducted with participants in both augmented arm rehabilitation groups. Normalization Process Theory was used to inform the topic guide and map the findings. Framework analysis was applied. Setting: Interviews were conducted in stroke survivors’ homes, at Glasgow Caledonian University and in hospital. Participants: 17 stroke survivors and five carers were interviewed after completion of augmented arm rehabilitation. Intervention: Evidence-based augmented arm rehabilitation (27 additional hours over six weeks), including therapist-led sessions and supported self-management. Results: Three main themes were identified: (1) acceptability of the intervention (2) supported self-management and (3) coping with the intervention. All stroke survivors coped well with the intensity of the augmented arm rehabilitation programme. The majority of stroke survivors engaged in supported self-management and implemented activities into their daily routine. However, the findings suggest that some stroke survivors (male >70 years) had difficulties with self-management, needing a higher level of support. Conclusion: Augmented arm rehabilitation commencing within nine weeks post stroke was reported to be well tolerated. The findings suggested that supported self-management seemed acceptable and appropriate to those who saw the relevance of the rehabilitation activities for their daily lives, and embedded them into their daily routines.
Endoplasmic reticulum stress regulates cell injury in lipopolysaccharide-induced nerve cells
Authors: Li Min , Zhang Ying , Wang Jixing 
Published: September 2020

Objective Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, and excessive endoplasmic reticulum (ER) stress is closely correlated with the cell injury caused by sepsis. This study aimed to analyze the possible role of ER stress in SAE cell models. Methods PC12 and MES23.5 cells were treated with increasing concentrations of lipopolysaccharides (LPS). The Cell Counting Kit-8 assay was used to detect cell viability and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining was performed to assess cell apoptosis. In addition, the protein expression levels of ER stress markers [GRP78, CHOP, inositol-requiring enzyme 1 (IRE1), and PKR-like ER kinase (PERK)] and apoptosis-related proteins (Bax, Bcl-2, caspase-3, and cleaved caspase-3) were analyzed using western blotting. Results LPS treatment activated ER stress markers in both the PC12 and MES23.5 cells. The overexpression of GRP78 significantly reduced cell viability and enhanced cell apoptosis in a time-dependent manner. An ER stress inhibitor, 4-PBA, significantly enhanced cell viability and inhibited the cell apoptosis induced by LPS. Therefore, an enhanced unfolded protein response (UPR) and UPR suppression may regulate cell apoptosis. Conclusions UPR was shown to be involved in regulating LPS-induced neuron injury. UPR could be a potential therapeutic target in SAE.
Local elasticity of the aorta in patients with type 2 diabetes mellitus
Authors: Dec-Gilowska Małgorzata , Trojnar Marcin , Makaruk Bogusław , Mosiewicz-Madejska Barbara , Dzida Grzegorz , Mosiewicz Jerzy 
Published: September 2020

Objective Arterial elasticity is important for assessing the state of an artery. This cross-sectional study aimed to non-invasively examine stiffness parameters of the ascending aorta in patients with type 2 diabetes mellitus (T2DM). Methods We studied 58 patients, including 38 with T2DM and 20 controls. The stiffness of the aorta was evaluated during transthoracic echocardiography. Aortic parameters of stiffness, such as the stiffness index, elasticity index, and compliance index, were calculated using the aortic maximal diameter, aortic minimal diameter, and blood pressure. Results Pulse pressure values were significantly higher patients with T2DM than in controls. The β index was significantly higher in patients with T2DM lasting for >7 years compared with those with T2DM lasting for <7 years. Mean aortic compliance was significantly lower in patients with a longer duration of diabetes than in those with a shorter duration of diabetes. Aortic elasticity was significantly lower in patients with diabetes and arterial hypertension compared with patients without diabetes with concomitant arterial hypertension. Conclusions Patients with T2DM, especially when T2DM is long-term, have increased stiffness and decreased compliance of the ascending aorta. Pulse pressure, which is a cardiovascular risk factor, is also significantly increased in patients with T2DM.
Potential of Private Autonomous Vehicles for Parcel Delivery
Authors: Schlenther Tilmann , Martins-Turner Kai , Bischoff Joschka Felix , Nagel Kai 
Published: September 2020

Using the same vehicles for both passenger and freight transport, to increase vehicle occupancy and decrease their number, is an idea that drives transport planners and is also being addressed by manufacturers. This paper proposes a methodology to simulate the behavior of such vehicles within an urban traffic system and evaluate their performance. The aim is to investigate the impacts of resignation from fleet ownership by a transport service company (TSC) operating on a city-wide scale. In the simulation, the service provider hires private autonomous cars for tour performance. Based on assumptions concerning the operation of such vehicles and TSCs, the software Multi-Agent Transport Simulation (MATSim) is extended to model vehicle and operator behavior. The proposed framework is applied to a case study of a parcel delivery service in Berlin serving a synthetic parcel demand. Results suggest that the vehicle miles traveled for freight purposes increase because of additional access and egress trips. Moreover, the number of vehicles en route is higher throughout the day. The lowering of driver costs can reduce the costs of the operator by approximately 74.5%. If the service provider additionally considers the resignation from fleet ownership, it might lower the operation cost by another 10%, not taking into account the costs of system transfer or risks like vehicle non-availability. From an economic perspective, the reduction of the overall number of vehicles in the system seems to be beneficial.
Mechanoreceptors in Remnant Posterior Cruciate Ligament and Achilles Tendon Allografts After Remnant-Preserving Posterior Cruciate Ligament Reconstruction: Hematoxylin-Eosin and Immunohistochemical Assessments
Authors: Chun Keun Churl , Shin Chang Hyun , Kang Hyun Tak , Kwon Hoi Young , Jo Hyang Jeong , Chun Churl Hong 
Published: September 2020

Background: Mechanoreceptor is a subtype of somatosensory receptor. It conveys extracellular stimuli through intracellular signal conduction via mechanically gated ion channel. It conveys not only kinetic stimuli but also pressure, stretching, touch, and even sound wave. Few studies have determined whether mechanoreceptors are present in Achilles tendon allografts used during remnant-preserving posterior cruciate ligament (PCL) reconstruction (PCLR). Purpose/Hypothesis: The purpose was to investigate whether mechanoreceptors are present in remnant tissues of the PCL and allograft tissues after PCLR. It was hypothesized that mechanoreceptors may be present in the remnant PCL tissue of the patients who underwent remnant PCLR technique. Study Design: Controlled laboratory study. Methods: Tissue samples were obtained from 14 participants who had undergone PCLR by means of Achilles tendon allografts (PCLR group) and from 4 healthy controls (control group). Among the PCLR group, 12 patients had undergone a remnant PCLR technique and the remaining 2 patients had undergone a nonremnant PCLR technique. In the PCLR group, we obtained samples during second-look arthroscopy or total knee arthroplasty after PCLR. In the control group, 4 biopsy specimens of normal PCL tissues were obtained from patients who had undergone other arthroscopic procedures. To check the presence of mechanoreceptors, immunohistochemical studies were performed on all biopsy specimens to identify neuronal and neurocytic markers by using monoclonal antibodies against glial fibrillary acidic protein, neuron-specific enolase, neurofilament, and S-100 protein. Only 1 of these markers needed to be positive to prove the presence of mechanoreceptors. Results: Neural tissue analogs, confirmed to be mechanoreceptors with monoclonal antibodies by the Ultraview DAB detection kit, were found in all specimens obtained from the control group. Mechanoreceptors were not found in the allograft specimens. However, remnant PCL tissues were found to have mechanoreceptors in 11 of 12 samples (91.7%). Conclusion: The results demonstrate that Achilles tendon allografts lack mechanoreceptors. This study can be used as histological evidence to support the advantage of remnant-preserving techniques for PCLR because they preserve proprioception. Clinical Relevance: To preserve proprioception, which leads to better functional outcome, using the remnant technique is a better procedure for PCL reconstruction.
Winter LVAD implantation is associated with adverse clinical outcomes
Authors: Imamura Teruhiko , Combs Pamela , Siddiqi Umar , Cohen William , Besser Stephanie , LaBuhn Colleen , Mirzai Saeid , Jeevanandam Valluvan 
Published: September 2020

Background: The seasonal variation of incidence and severity of heart failure is well known. However, the impact of seasonal variation on clinical outcomes following left ventricular assist device (LVAD) implantation remains unknown. Methods: We retrospectively reviewed consecutive patients who received LVAD implantation between January 2014 and December 2016 along with their first year of post-implant outcomes. Clinical outcomes were compared between those with winter LVAD implantation (between October and March) and those with non-winter LVAD implantation. Results: 168 patients with a median age of 57 years and 130 males were included. There was no seasonal difference in the number of LVAD implantations. One-year survival free from major adverse events was significantly lower in the winter implant group ( n = 88) compared to the non-winter group ( n = 80) (44% vs 61%) with an adjusted hazard ratio of 1.81 (95% confidence interval 1.11–2.90, p = 0.014), largely due to a higher rate of heart failure readmission in the winter implant patients (incidence rate ratio 2.29, 95% confidence interval 0.89–5.84). Conclusion: Patients who underwent LVAD implantation during the winter season had a higher heart failure readmission rate. A detailed mechanism and therapeutic strategy given our findings warrant further investigation.
Intermittent hemodiafiltration as a down-step transition therapy in patients with acute kidney injury admitted to intensive care unit who initially underwent continuous venovenous hemodiafiltration
Authors: Scherer Patricia Faria , Iizuka Ilson Jorge , Ammirati Adriano Luiz , Doher Marisa Petrucelli , Matsui Thais Nemoto , dos Santos Bento Fortunato Cardoso , Monte Julio Cesar Martins , Batista Marcelo Costa , Pereira Virgilio Gonçalves , dos Santos Oscar Fernando Pavão , Durão Marcelino de Souza 
Published: September 2020

Background/Aims: Continuous renal replacement therapies (CRRT) are initially employed in patients with acute kidney injury (AKI) in ICU setting. After the period of serious illness, hemodialysis is usually used as a mode of transition from CRRT. Intermittent hemodiafiltration (HDF) is not commonly applied in this scenario. Objectives: To evaluate the feasibility of using HDF as transition therapy after CVVHDF in critically patients with AKI. Methods: An observational and prospective pilot study was conducted in ICU patients with dialysis-requiring AKI. Patients were initially treated with CVVHDF and, after medical improvement, those who still needed renal replacement therapy were switched to HDF treatment. Results: Ten Patients underwent 53 HDF sessions (mean of 5.3 sessions/patient). The main cause of renal dysfunction was sepsis ( N = 7; 70%). The APACHE II mean score was 27.6 ± 6.9. During HDF treatment, the urea reduction ratio was 64.5 ± 7.5%, for β-2 microglobulin serum levels the percentage of decrease was 42.0 ± 7.8%, and for Cystatin C was 36.2 ± 6.9%. Five episodes of arterial hypotension occurred (9.4% of sessions). There were 20 episodes of electrolytic disturbance (37.7% of sessions), mainly hypophosphatemia. No pyrogenic or suggestive episode of bacteremia was observed. Conclusion: Hemodiafiltration was safe and efficient to treat critically ill patients with acute kidney injury during the transition phase from continuous to intermittent dialysis modality. Special attention should be paid regarding the occurrence of electrolytic disturbance, mainly hypophosphatemia.
First in vivo assessment of RAS-Q technology as lung support device for pulmonary hypertension
Authors: Verbelen Tom , Halwes Michael , Meyns Bart 
Published: September 2020

Objectives: To assess the in vivo hemodynamic effects on the pressure overloaded right ventricle of RAS-Q® technology, the world’s first gas exchanger with a fully integrated compliance. Methods: In six acute in vivo trials RAS-Q was implanted in sheep between the pulmonary artery and left atrium. Right ventricular pressure overload was induced by pulmonary artery banding. Pressures and flows were recorded in baseline, moderate and severe pulmonary hypertension conditions. In one trial, RAS-Q was benchmarked against the pediatric Quadrox-i®. Results: With 1.00 and 1.17 L/min, RAS-Q delivered 31% and 39% of the total cardiac output in moderate and severe pulmonary hypertension, respectively. Pulmonary artery pressures and mean pulmonary artery pressure/mean arterial blood pressure ratio successfully decreased, implying a successful right ventricular unloading. Cardiac output was restored to normal levels in both pulmonary hypertension conditions. With both devices in parallel, RAS-Q provided three times higher flow rates and a 10 times higher pressure relief, compared to the pediatric Quadrox-i. Conclusion: A gas exchanger with a fully integrated compliance better unloads the right ventricle compared to a non-compliant gas exchanger and it can restore cardiac output to normal levels in cases of severe pulmonary hypertension.
Intimate Others and the Othering of intimates: The gendered psycho-politics of the entangled relational
Authors: Dalal Farhad 
Published: September 2020

The article begins with an exploration of the ambivalence experienced by the author when invited to speak at a conference in Tel Aviv, Israel. This followed by introducing two notions, ‘ethical distress’ and ‘entangled relational’, both of which speak to the ambivalence. Next, it is argued that the notion of ‘the relational’ in psychoanalytic literature is largely apolitical, and that it has required women—who speak from the margins—to theorize and incorporate the political into the relational frame. I argue that the ‘entangled relational’ subsumes and politicizes ‘the relational’. The notion of ‘intimate others’ is utilized to think about processes of Othering and the emotional consequences that follow out of it. This is followed by Nancy Chodorow and Lynne Layton’s politicized feminist theorizations. Layton concludes that psycho-developmental processes taking place under conditions of patriarchy necessarily lead to men and women suffering from a form of narcissistic injury. The article then uses all these ideas to think about the psychological consequences of militarization on the male and female citizens of militarized societies, and in particular about the psychological consequences for those living in the Israeli-Palestinian context. The article concludes with some thoughts about the possible function and task of psychotherapy in militarized contexts.
Volumetric Markers of Body Composition May Improve Personalized Prediction of Major Arterial Bleeding After Pelvic Fracture: A Secondary Analysis of the Baltimore CT Prediction Model Cohort
Authors: Dreizin David , Rosales Remberto , Li Guang , Syed Hassan , Chen Rong 
Published: September 2020

The Baltimore computed tomography (CT) prediction model for bleeding pelvic fractures is a multivariable decision tool that predicts angiopositivity from pelvic hematoma volume, active arterial bleeding, fracture patterns, and atherosclerosis. We hypothesized that quantitative markers of body composition and frailty could further improve model performance. Methods: This work is a retrospective secondary analysis of a single institution cohort used in the development of the Baltimore CT prediction model. The cohort includes 115 consecutive patients that underwent admission contrast-enhanced CT of the abdomen and pelvis for blunt trauma with pelvic ring disruption followed by conventional angiography. Major arterial injury requiring angioembolization served as the outcome variable. Angioembolization was required in 73/115 patients (63% of the cohort). Average age was 46.9 years (±SD 20.4). Body composition measurements were determined as 2-dimensional (2D) or 3-dimensional (3D) parameters and included mid-L3 trabecular bone attenuation, abdominal visceral fat area or volume, and percent muscle fat fraction (as a marker of sarcopenia) measured using segmentation and histogram analysis. Results: Models incorporating 2D (Model B) or 3D markers (model C) of body composition showed improvement over the original Baltimore model (model A) in all parameters of performance, quality, and fit (area under the receiver-operating curve [AUC], Akaike information criterion, Brier score, Hosmer-Lemeshow test, and adjusted-R2). Area under the receiver-operating curve increased from 0.83 (A), to 0.86 (B), and 0.88 (C). The greatest improvement was seen with 3D parameters. Conclusion: Once automated, quantitative visualization tools providing “free” 3D body composition information can be expected to improve personalized precision diagnostics, outcome prediction, and decision support in patients with bleeding pelvic fractures.