bluuebunny/crossref_metadata_2025_split huggingface dataset:
Superassembly of Porous Fetet(NiFe)octO Frameworks with Stable Octahedron and Multistage Structure for Superior Lithium–Oxygen Batteries
Authors: He Biao , Wang Jun , Liu Jiaqing , Li Yong , Huang Qishun , Hou Yue , Li Gaoyang , Li Jiajia , Zhang Runhao , Zhou Junjie , Tian Wei , Du Yong , Dang Feng , Wang Hongchao , Kong Biao 
Published: April 2020

AbstractPromising lithium–oxygen batteries (LOBs) with extra‐high capacities have attracted increasing attention for use in future electric devices. However, the challenges facing this complicated battery system still limit their practical applications. These challenges mainly consist of inefficient product evolution and low‐activity catalysts. In present work, a cation occupying, modified 3D‐architecture NiFeO cubic spinel is constructed via superassembly strategy to achieve a high rate, stable electrocatalyst for LOBs. The octahedron predominant spinel provides a stable polycrystal structure and optimized electronic structure, which dominates the discharge/charge products evolution with multiformation kinetics of crystal Li2O2 and Li2−xO2 at low and high rate conditions and energetically favors the mass transport between the electrode/electrolyte interface. Simultaneously, the porous NiFeO framework provides adequate spaces for Li2O2 accommodation and complex channels for sufficient electrolyte, oxygen, and ion transportation, which dramatically alter the cathode catalysis for an unprecedented performance. As a consequence, a large specific capacity of 23413 mAh g−1 and an excellent cyclability of 193 cycles at a high current of 1000 mA g−1, and 300 cycles at a current of 500 mA g−1, are achieved. The present work provides intrinsic insights into designing high‐performance metal oxide electrocatalysts for Li–O2 batteries with fine‐tuned electronic and frame structure.
2D Amorphous V2O5/Graphene Heterostructures for High‐Safety Aqueous Zn‐Ion Batteries with Unprecedented Capacity and Ultrahigh Rate Capability
Authors: Wang Xiao , Li Yaguang , Wang Sen , Zhou Feng , Das Pratteek , Sun Chenglin , Zheng Shuanghao , Wu Zhong‐Shuai 
Published: April 2020

AbstractRechargeable aqueous zinc‐ion batteries (ZIBs) are appealing due to their high safety, zinc abundance, and low cost. However, developing suitable cathode materials remains a great challenge. Herein, a novel 2D heterostructure of ultrathin amorphous vanadium pentoxide uniformly grown on graphene (A‐V2O5/G) with a very short ion diffusion pathway, abundant active sites, high electrical conductivity, and exceptional structural stability, is demonstrated for highly reversible aqueous ZIBs (A‐V2O5/G‐ZIBs), coupling with unprecedented high capacity, rate capability, long‐term cyclability, and excellent safety. As a result, 2D A‐V2O5/G heterostructures for stacked ZIBs at 0.1 A g−1 display an ultrahigh capacity of 489 mAh g−1, outperforming all reported ZIBs, with an admirable rate capability of 123 mAh g−1 even at 70 A g−1. Furthermore, the new‐concept prototype planar miniaturized zinc‐ion microbatteries (A‐V2O5/G‐ZIMBs), demonstrate a high volumetric capacity of 20 mAh cm−3 at 1 mA cm−2, long cyclability; holding high capacity retention of 80% after 3500 cycles, and in‐series integration, demonstrative of great potential for highly‐safe microsized power sources. Therefore, the exploration of such 2D heterostructure materials with strong synergy is a reliable strategy for developing safe and high‐performance energy storage devices.
Electrolytes and Interphases in Sodium‐Based Rechargeable Batteries: Recent Advances and Perspectives
Authors: Eshetu Gebrekidan Gebresilassie , Elia Giuseppe Antonio , Armand Michel , Forsyth Maria , Komaba Shinichi , Rojo Teofilo , Passerini Stefano 
Published: April 2020

AbstractFor sodium (Na)‐rechargeable batteries to compete, and go beyond the currently prevailing Li‐ion technologies, mastering the chemistry and accompanying phenomena is of supreme importance. Among the crucial components of the battery system, the electrolyte, which bridges the highly polarized positive and negative electrode materials, is arguably the most critical and indispensable of all. The electrolyte dictates the interfacial chemistry of the battery and the overall performance, having an influence over the practical capacity, rate capability (power), chemical/thermal stress (safety), and lifetime. In‐depth knowledge of electrolyte properties provides invaluable information to improve the design, assembly, and operation of the battery. Thus, the full‐scale appraisal of both tailored electrolytes and the concomitant interphases generated at the electrodes need to be prioritized. The deployment of large‐format Na‐based rechargeable batteries also necessitates systematic evaluation and detailed appraisal of the safety‐related hazards of Na‐based batteries. Hence, this review presents a comprehensive account of the progress, status, and prospect of various Na+‐ion electrolytes, including solvents, salts and additives, their interphases and potential hazards.
Expanding the clinical spectrum of mitochondrial 3‐hydroxy‐3‐methylglutaryl‐CoA synthase deficiency with Turkish cases harboring novel HMGCS2 gene mutations and literature review
Authors: Kılıç Mustafa , Dorum Sevil , Topak Ali , Yazıcı Mutlu U. , Ezgu Fatih S. , Coskun Turgay 
Published: April 2020

AbstractMitochondrial 3‐hydroxy‐3‐methylglutaryl‐CoA synthase (mHS) deficiency is a very rare autosomal recessive inborn error of ketone body synthesis and presents with hypoketotic hypoglycemia, metabolic acidosis, lethargy, encephalopathy, and hepatomegaly with fatty liver precipitated by catabolic stress. We report acute presentation of two patients from unrelated two families with novel homozygous c.862C>T and c.725‐2A>C mutations, respectively, in HMGCS2 gene. Affected patients had severe hypoketotic hypoglycemia, lethargy, encephalopathy, severe metabolic and lactic acidosis and hepatomegaly after infections. Surprisingly, molecular screening of the second family showed more affected patients without clinical findings. These cases expand the clinic spectrum of this extremely rare disease.
Hydrothermal Generation of Conjugated Polymers Using the Example of Pyrrone Polymers and Polybenzimidazoles
Authors: Taublaender M. Josef , Mezzavilla Stefano , Thiele Sophia , Glöcklhofer Florian , Unterlass Miriam M. 
Published: April 2020

AbstractVarious polyimides and polyamides have recently been prepared via hydrothermal synthesis in nothing but H2O under high‐pressure and high‐temperature conditions. However, none of the prepared polymers feature a truly conjugated polymer backbone. Here, we report on an expansion of the synthetic scope of this straightforward and inherently environmentally friendly polymerization technique to the generation of conjugated polymers. Selected representatives of two different polymer classes, pyrrone polymers and polybenzimidazoles, were generated hydrothermally. We present a mechanistic discussion of the polymer formation process as well as an electrochemical characterization of the most promising product.
Host–Guest Complexation of Amphiphilic Molecules at the Air–Water Interface Prevents Oxidation by Hydroxyl Radicals and Singlet Oxygen
Authors: Geng Wen‐Chao , Zhang Dongmei , Gong Chu , Li Zhihao , Barraza Kevin M. , Beauchamp Jesse L. , Guo Dong‐Sheng , Zhang Xinxing 
Published: April 2020

AbstractThe oxidation of antioxidants by oxidizers imposes great challenges to both living organisms and the food industry. Here we show that the host–guest complexation of the carefully designed, positively charged, amphiphilic guanidinocalix[5]arene pentadodecyl ether (GC5A‐12C) and negatively charged oleic acid (OA), a well‐known cell membrane antioxidant, prevents the oxidation of the complex monolayers at the air–water interface from two potent oxidizers hydroxyl radicals (OH) and singlet delta oxygen (SDO). OH is generated from the gas phase and attacks from the top of the monolayer, while SDO is generated inside the monolayer and attacks amphiphiles from a lateral direction. Field‐induced droplet ionization mass spectrometry results have demonstrated that the host–guest complexation achieves steric shielding and prevents both types of oxidation as a result of the tight and “sleeved in” physical arrangement, rather than the chemical reactivity, of the complexes.
[n]‐Cyclo‐9,9‐dibutyl‐2,7‐fluorene (n=4, 5): Nanoring Size Influence in Carbon‐Bridged Cyclo‐para‐phenylenes
Authors: Sicard Lambert , Lucas Fabien , Jeannin Olivier , Bouit Pierre‐Antoine , Rault‐Berthelot Joëlle , Quinton Cassandre , Poriel Cyril 
Published: April 2020

AbstractFor the last ten years, ring‐shaped π‐conjugated macrocycles possessing radially directed π‐orbitals have been subject to intense research. The electronic properties of these rings are deeply dependent on their size. However, most studies involve the flagship family of nanorings: the cyclo‐para‐phenylenes. We report herein the synthesis and study of the first examples of cyclofluorenes possessing five constituting fluorene units. The structural, optical and electrochemical properties were elucidated by X‐ray crystallography, UV‐vis absorption and fluorescence spectroscopy, and cyclic voltammetry. By comparison with a shorter analogue, we show how the electronic properties of [5]‐cyclofluorenes are drastically different from those of [4]‐cyclofluorenes, highlighting the key role played by the ring size in the cyclofluorene family.
A novel type of waterborne fluorescent nanofiber membranes with effectively suppressed ACQ phenomenon: Fabrication, properties, and applications
Authors: Wang Lin , Wang Jun , Yang Lei , Ding Yexin , Xie Yixiao , Wang Fangming , Chen Lizhuang , Li Weili , Yan Hui 
Published: April 2020

AbstractIn this research, a novel type of waterborne fluorescent nanofiber membranes (WNFM) based on fluorescent acrylic latex (FAL) has been developed by electrospinning method using environment‐friendly water as the spinning solvent. FALs are synthesized by doping Rhodamine B (Rh B) into acrylate monomers through emulsion polymerization, and then polyvinyl alcohol (PVA) is added to fabricate a series of WNFM via electrospinning process. As the hydrophilic emulsifier sodium dodecyl sulfate enriches on the surface of the latex, a portion of Rh B can be adsorbed onto the surface of FAL and form an electrical double layer to prevent its aggregation, which accounts for the enhancement in fluorescence of FALs. The relationships between the preparation conditions, morphology and properties of WNFM have been studied with a combination of techniques including fluorometry and microscopies. The developed waterborne fluorescent nanofiber membranes demonstrate a good water‐resistant property with a linear response of photoluminescence intensity to temperature for many cycles. The study points a new direction to develop the nanofiber membrane using environment‐friendly water as a spinning solvent in electrospinning and realize its fluorescent functionalization.
Erfahrungen mit der Nachrechnung von fünf Wehranlagen nach TbW
Authors: Zimmer Mirka , Eggeling Thomas 
Published: April 2020

AbstractDie Altersstruktur und der damit verbundene Zustand der Wehranlagen in Deutschland fordern in den kommenden Jahren an zahlreichen Anlagen tief greifende bauliche Maßnahmen. Gleichzeitig sind die personellen Ressourcen für die Umsetzung dieser Aufgaben begrenzt.Das Wasserstraßen‐Neubauamt (WNA) Aschaffenburg verfolgt deshalb ein Konzept zur Ermittlung des Instandsetzungs‐ bzw. Ersatzbedarfs für die Wehranlagen am Main. Um die Dringlichkeit und den Umfang einzelner Maßnahmen an den Anlagen zu erkunden und abzuschätzen, werden zunächst die Wehranlagen Freudenberg, Rothenfels, Steinbach, Harrbach und Erlabrunn tiefergehend auf ihren Zustand hin untersucht.Im Rahmen der Zustandsbegutachtung ist die innere Standsicherheit der bestehenden Wehrpfeiler betrachtet worden. Dies ist auf Grundlage des BAW‐Merkblatts „Bewertung der Tragfähigkeit bestehender, massiver Wasserbauwerke (TbW)“ erfolgt. Am Beispiel der Wehranlage Erlabrunn wird hier die Vorgehensweise dargestellt und Schlussfolgerungen daraus gezogen. Insbesondere die Nachrechnung der unbewehrten Betonbauteile im Bereich der Verschlussnischen stellt eine große Herausforderung dar. Es werden Berechnungsansätze für die Detailnachweise in diesen Bereichen aufgezeigt.Durch die analoge Betrachtung von fünf Wehranlagen ist ein anschließender Vergleich gegeben, welcher die Priorisierung der Grundinstandsetzungen möglich macht.
Protein‐inorganic calcium‐phosphate supraparticles as a robust platform for enzyme co‐immobilization
Authors: Caparco Adam A. , Bommarius Bettina R. , Bommarius Andreas S. , Champion Julie A. 
Published: April 2020

AbstractImmobilization of enzymes provides many benefits, including facile separation and recovery of enzymes from reaction mixtures, enhanced stability, and co‐localization of multiple enzymes. Calcium‐phosphate‐protein supraparticles imbued with a leucine zipper binding domain (ZR) serve as a modular immobilization platform for enzymes fused to the complementary leucine zipper domain (ZE). The zippers provide high‐affinity, specific binding, separating enzymatic activity from the binding event. Using fluorescent model proteins (mCherryZE and eGFPZE), an amine dehydrogenase (AmDHZE), and a formate dehydrogenase (FDHZE), the efficacy of supraparticles as a biocatalytic solid support was assessed. Supraparticles demonstrated several benefits as an immobilization support, including predictable loading of multiple proteins, structural integrity in a panel of solvents, and the ability to elute and reload proteins without damaging the support. The dual‐enzyme reaction successfully converted ketone to amine on supraparticles, highlighting the efficacy of this system.
Effect of omission of surgery on survival in patients aged 80 years and older with early-stage hormone receptor-positive breast cancer
Authors: de Boer A Z , de Glas N A , Marang-van de Mheen P J , Dekkers O M , Siesling S , de Munck L , de Ligt K M , Liefers G J , Portielje J E A , Bastiaannet E 
Published: April 2020

Abstract

Background
Surgery is increasingly being omitted in older patients with operable breast cancer in the Netherlands. Although omission of surgery can be considered in frail older patients, it may lead to inferior outcomes in non-frail patients. Therefore, the aim of this study was to evaluate the effect of omission of surgery on relative and overall survival in older patients with operable breast cancer.

Methods
Patients aged 80 years or older diagnosed with stage I–II hormone receptor-positive breast cancer between 2003 and 2009 were selected from the Netherlands Cancer Registry. An instrumental variable approach was applied to minimize confounding, using hospital variation in rate of primary surgery. Relative and overall survival was compared between patients treated in hospitals with different rates of surgery.

Results
Overall, 6464 patients were included. Relative survival was lower for patients treated in hospitals with lower compared with higher surgical rates (90·2 versus 92·4 per cent respectively after 5 years; 71·6 versus 88·2 per cent after 10 years). The relative excess risk for patients treated in hospitals with lower surgical rates was 2·00 (95 per cent c.i. 1·17 to 3·40). Overall survival rates were also lower among patients treated in hospitals with lower compared with higher surgical rates (48·3 versus 51·3 per cent after 5 years; 15·0 versus 19·7 per cent after 10 years respectively; adjusted hazard ratio 1·07, 95 per cent c.i. 1·00 to 1·14).

Conclusion
Omission of surgery is associated with worse relative and overall survival in patients aged 80 years or more with stage I–II hormone receptor-positive breast cancer. Future research should focus on the effect on quality of life and physical functioning.
Revitalization of Indian SMEs for sustainable development through innovation
Authors: Raghuvanshi Juhi , Agrawal Rajat 
Published: April 2020

AbstractGlobalization has led to the metamorphosis of SMEs for over a decade and half with the onset of innovation process. Despite this, several barriers prevent the SMEs owners from acting as intelligent and proactive firms. This paper seeks to understand what and how barriers related to innovation processes and relationships among them in SMEs influence entrepreneurs to innovate and to reap the benefits of innovation. We address this by identifying factors and determining the causal relationship among the barriers using Decision Making Trial and Evaluation Laboratory technique (DEMATEL) approach. The original contribution of the study lies in the fact that no study so far determines the causal relationship among the barriers to innovation in SMEs. Entrepreneurs and academicians would stand to gain by knowing which barrier leads to which specific outcome barrier. Knowledge and elimination of these barriers may help in fostering the process of innovation in SMEs.
Market drivers of sustainability and sustainability learning capabilities: The moderating role of sustainability control systems
Authors: Wijethilake Chaminda , Upadhaya Bedanand 
Published: April 2020

AbstractThis study examines (i) the impact of market drivers of sustainability on the adoption of sustainability learning capabilities and (ii) the moderating role of sustainability control systems (SCS) on the relationship between market drivers of sustainability and sustainability learning capabilities. Drawing on the levers of control framework, stakeholder theory and organisational learning literature, survey data were collected from 175 large scale local and multinational companies operating in Sri Lanka. Findings reveal that market drivers of sustainability have a significant positive impact on sustainability learning capabilities. Whereas the interactive use of SCS shows a positive moderating impact, the diagnostic use of SCS shows a negative impact. The study enhances our understanding of (i) the influence of market drivers of sustainability on the adoption of sustainability learning capabilities and (ii) the use of SCS in enabling sustainability learning capabilities. The study reveals novel insights for managers responding to changing market drivers of sustainability, on how to (re)align different uses of SCS to enable sustainability learning capabilities.
Extraction of recombinant periplasmic proteins under industrially relevant process conditions: Selectivity and yield strongly depend on protein titer and methodology
Authors: Schimek Clemens , Egger Esther , Tauer Christopher , Striedner Gerald , Brocard Cécile , Cserjan‐Puschmann Monika , Hahn Rainer 
Published: April 2020

AbstractIn this work, we attempted to identify a method for the selective extraction of periplasmic endogenously expressed proteins, which is applicable at an industrial scale. For this purpose, we used an expression model that allows coexpression of two fluorescent proteins, each of which is specifically targeted to either the cytoplasm or periplasm. We assessed a number of scalable lysis methods (high‐pressure homogenization, osmotic shock procedures, extraction with ethylenediaminetetraacetic acid, and extraction with deoxycholate) for the ability to selectively extract periplasmic proteins rather than cytoplasmic proteins. Our main conclusion was that although we identified industrially scalable lysis conditions that significantly increased the starting purity for further purification, none of the tested conditions were selective for periplasmic protein over cytoplasmic protein. Furthermore, we demonstrated that efficient extraction of the expressed recombinant proteins was largely dependent on the overall protein concentration in the cell.
What's in a synonym? A nose by any other name would smell
Authors: Neumann Paul E. 
Published: April 2020

AbstractIntroductionCommunication in the biomedical sciences and clinical practice would be clearer if everyone used the same set of technical terms. Technical vocabularies, such as international standard terminologies, are attempts to avoid common linguistic problems, such as synonymy (many names for a single entity) and polysemy (many meanings for a single term).Materials and MethodsEfforts made in human anatomical nomenclature since the late 19th century to deal with these issues were reviewed.ResultsThe new designations official term, equivalent term, synonym and related term are defined, and current challenges (e.g., eponyms) are identified.DiscussionThe addition of synonyms and related terms to the international standard anatomical terminology allows indexing of these terms to the official terms and evaluation of the relationships between terms.
Chemokines and chemokine receptors: A new strategy for breast cancer therapy
Authors: Liu Hui , Yang Zhenjiang , Lu Wenping , Chen Zhen , Chen Lianyu , Han Shuyan , Wu Xiaoyu , Cai Tiange , Cai Yu 
Published: April 2020

AbstractChemokines and chemokine receptors not only participate in the development of tissue differentiation, hematopoiesis, inflammation, and immune regulation but also play an important role in the process of tumor development. The role of chemokines and chemokine receptors in tumors has been emphasized in recent years. More and more studies have shown that chemokines and chemokine receptors are closely related to the occurrence, angiogenesis, metastasis, drug resistance, and immunity of breast cancer. Here, we review recent progression on the roles of chemokines and chemokine receptors in breast cancer, and discuss the possible mechanism in breast cancer that might facilitate the development of new therapies by targeting chemokines as well as chemokine receptors. Chemokines and chemokine receptors play an important role in the occurrence and development of breast cancer. In‐depth study of chemokines and chemokine receptors can provide intervention targets for breast cancer biotherapy. The regulation of chemokines and chemokine receptors may become a new strategy for breast cancer therapy.