bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and data quality of EEG recorded simultaneously with multi-band fMRI
Authors: Egan Maximillian K. , Larsen Ryan , Wirsich Jonathan , Sutton Brad P. , Sadaghiani Sepideh 
Published: August 2020

AbstractPurposeSimultaneously recorded electroencephalography and functional magnetic resonance imaging (EEG-fMRI) is highly informative yet technically challenging. Until recently, there has been little information about EEG data quality and safety when used with newer multi-band (MB) fMRI sequences. Here, we measure the relative heating of a MB protocol compared with a standard single-band (SB) protocol considered to be safe. We also evaluated EEG quality recorded concurrently with the MB protocol on humans.Materials and MethodsWe compared radiofrequency (RF)-related heating at multiple electrodes and magnetic field magnitude,B1+RMS, of a MB fMRI sequence with whole-brain coverage (TR = 440 ms, MB factor = 4) against a previously recommended, safe SB sequence using a phantom outfitted with a 64-channel EEG cap. Next, 9 human subjects underwent eyes-closed resting state EEG-fMRI using the MB sequence. Additionally, in three of the subjects resting state EEG was recorded also during the SB sequence and in an fMRI-free condition to directly compare EEG data quality across scanning conditions. EEG data quality was assessed by the ability to remove gradient and cardioballistic artifacts along with a clean spectrogram.ResultsThe heating induced by the MB sequence was lower than that of the SB sequence by a factor of 0.73 ± 0.38. This is consistent with an expected heating ratio of 0.64, calculated from the square of the ratio ofB1+RMSvalues of the sequences. In the resting state EEG data, gradient and cardioballistic artifacts were successfully removed using traditional template subtraction. All subjects showed an individual alpha peak in the spectrogram with a posterior topography characteristic of eyes-closed EEG. The success of artifact rejection for the MB sequence was comparable to that in traditional SB sequences.ConclusionsOur study shows thatB1+RMSis a useful indication of the relative heating of fMRI protocols. This observation indicates that simultaneous EEG-fMRI recordings using this MB sequence can be safe in terms of RF-related heating, and that EEG data recorded using this sequence is of acceptable quality after traditional artifact removal techniques.
Accurate identification and quantification of commensal microbiota bound by host immunoglobulins
Authors: Jackson Matthew A. , Pearson Claire , Ilott Nicholas E. , Huus Kelsey E. , Hegazy Ahmed N. , Webber Jonathan , Finlay B. Brett , Macpherson Andrew J. , Powrie Fiona , Lam Lilian H. 
Published: August 2020

AbstractBackgroundIdentifying which taxa are targeted by immunoglobulins can uncover important host-microbe interactions. Immunoglobulin binding of commensal taxa can be assayed by sorting bound bacteria from samples and using amplicon sequencing to determine their taxonomy, a technique most widely applied to study Immunoglobulin A (IgA-Seq). Previous experiments have scored taxon binding in IgA-Seq datasets by comparing abundances in the IgA bound and unbound sorted fractions. However, as these are relative abundances, such scores are influenced by the levels of the other taxa present and represent an abstract combination of these effects. Diversity in the practical approaches of prior studies also warrants benchmarking of the individual stages involved. Here, we provide a detailed description of the design strategy for an optimised IgA-Seq protocol. Combined with a novel scoring method for IgA-Seq datasets that accounts for the aforementioned effects, this platform enables accurate identification and quantification of commensal gut microbiota targeted by host immunoglobulins.ResultsUsing germ-free andRag1−/−mice as negative controls, and a strain-specific IgA antibody as a positive control, we determine optimal reagents and fluorescence activated cell sorting (FACS) parameters for IgA-Seq. Using simulated IgA-Seq data, we show that existing IgA-Seq scoring methods are influenced by pre-sort relative abundances. This has consequences for the interpretation of case-control studies where there are inherent differences in microbiota composition between groups. We show that these effects can be addressed using a novel scoring approach based on posterior probabilities. Finally, we demonstrate the utility of both the IgA-Seq protocol and probability-based scores by examining both novel and published data fromin vivodisease models.ConclusionsWe provide a detailed IgA-Seq protocol to accurately isolate IgA-bound taxa from intestinal samples. Using simulated and experimental data, we demonstrate novel probability-based scores that adjust for the compositional nature of relative abundance data to accurately quantify taxon-level IgA binding. All scoring approaches are made available in the IgAScores R package. These methods should improve the generation and interpretation of IgA-Seq datasets and could be applied to study other immunoglobulins and sample types.
Suppression of p16 alleviates the senescence-associated secretory phenotype
Authors: Buj Raquel , Leon Kelly E. , Aird Katherine M. 
Published: August 2020

AbstractOncogene induced senescence (OIS) is characterized by increased expression of the cell cycle inhibitor p16, leading to a hallmark cell cycle arrest. Suppression of p16 in this context drives proliferation, senescence bypass, and contributes to tumorigenesis. OIS cells are also characterized by the expression and secretion of a widely variable group of factors collectively termed the senescence-associated secretory phenotype (SASP). The SASP can be both beneficial and detrimental and affects the microenvironment in a highly context-dependent manner. The relationship between p16 suppression and the SASP remains unclear. Here, we show that knockdown of p16 decreases expression of the SASP factors and pro-inflammatory cytokinesIL6andCXCL8in both RASG12V-and BRAFV600E-induced senescence. Notably, this is likely not due to suppression of senescence asLMNB1and cyclin A expression remain low and p21 remains high. Moreover, low p16 expression in both cancer cell lines and patient samples correspond to decreased SASP gene expression, suggesting this is a universal effect of loss of p16 expression. Together, our data suggest that p16 transcriptionally regulates SASP gene expression, which has implications for understanding how p16 modulates both the senescent and tumor microenvironment.
Labour migration in ASEAN: Indonesian migrant workers in Johor Bahru, Malaysia
Authors: Arisman Arisman , Jaya Ratnawati Kusuma 
Published: August 2020

PurposeThe purpose of this article is to explain and share about labour migration for employment purposes issues from the perspective of a sending and receiving country in Association of Southeast Asian Nations (ASEAN) (Indonesia; sending state and Malaysia; receiving state) on managing the international labour migration between the two countries.Design/methodology/approachThe research adopting “mixed methods”, mixing of quantitative and qualitative data within a single investigation or sustained programme of inquiry. The activity includes collecting primary data in two countries. Data collection is done by distributing questionnaires to migrant workers in the receiving states and used indepth interview to 10 stakeholders in the sending states.FindingsThe protection of migrant workers in Johor Bahru is still weak. The graph shows that Indonesian migrant workers in Johor mostly have their documents kept by their employer. Fisheries sector has the highest percentage of workers whose documents are retained by the employer. Meanwhile the sector in which the worker mostly do not get a weekly one day off is the domestic worker. Overall, this means that Malaysia has to put more attention on the existing regulation in order to create a more comfortable working environment.Originality/valueThis paper observe three parameters such as working hour, who keep the passport of the Indonesian migrant workers and weekly one day off relate to working condition of Indonesian migrant workers.
Consumer communication when eating out of home: the role of technology
Authors: Bray Jeff , Hartwell Heather , Appleton Katherine , Price Sarah 
Published: August 2020

PurposeDespite growing demand, little product information is available when eating out. Information that is provided is often not well understood leading to a lack of consumer control and acting as a barrier to healthy food choices. The AIDA model which highlights the key stages of effective marketing communication (awareness, interest, desire and action) is applied. Information provided through technological solutions is examined to provide clear guidance on future use.Design/methodology/approachExploratory qualitative methods through four focused group discussions allowed consumers views to be probed in-depth and key themes to emerge through thematic analysis.FindingsIn addition to the four key elements of the AIDA model, accessibility and relevance are found to be key constructs relevant to food information provision. Accessibility highlights the need for quick and clear data display, while relevance stresses how salient information is key to each consumer. Technological solutions may offer the most responsive, effective and trusted way to provide enhanced information.Practical implicationsWith increasing consumer demand for clear information, a competitive advantage can be gained through the provision of personalised enhanced dish information when eating out. Findings from this study highlight consumers’ desire for online (app or website-based) platforms.Social implicationsThe provision of enhanced food information when eating out has clear public health implications and may influence choice leading to a reduction in non-communicable disease.Originality/valueThis study evaluates consumers’ perceptions to the provision of enhanced food information out of home providing novel insights and guidance for both managerial and societal impact.
Do linking social, human and financial capital matter for the labour force in Lao PDR? The relationship between occupational well-being and life satisfaction
Authors: Daovisan Hanvedes , Chamaratana Thanapauge 
Published: August 2020

PurposeThe labour force is the cornerstone of the economy of Lao People's Democratic Republic (Lao PDR). Labour market growth seems to be vigorously increased by using labourers' capital to foster work-related employees’ well-being, through enhancing their life satisfaction. This study examines whether linking social, human and financial capital are important for the labour force in Lao PDR and whether there is a positive relationship between occupational well-being and life satisfaction.Design/methodology/approachThe authors tested the hypotheses using partial least squares structural equation modelling (PLS-SEM). Using a systematic sampling approach, the study employed structured interviews; data were collected from 1,037 members of the labour force, between 2017 and 2019.FindingsThe structural model indicated that linking social and human capital and occupational well-being were significantly positively related to life satisfaction. However, the present study found that financial capital was non-significantly related to life satisfaction. The substantive and practical implications of these findings are discussed.Originality/valueThis is the first research study to investigate the relationship between occupational well-being and life satisfaction using a Laotian sample.
Measuring event experience and its behavioral consequences in the context of a sports mega-event
Authors: Sorrentino Annarita , Fu Xiaoxiao , Romano Rosaria , Quintano Michele , Risitano Marcello 
Published: August 2020

PurposeThis study aims to analyze the impact of event experience on event satisfaction and intentions to return and recommend the destination.Design/methodology/approachRelationships among constructs were tested on data gathered from 542 tourists during the America's Cup World Series held in South Italy in April 2013 by using a structural equation modeling approach. Moreover, a multigroup analysis was developed to test the possible moderator factors.FindingsThe results revealed that event experience and event satisfaction had positive impacts on the intentions to recommend and return to the host destination. Moreover, nationality, gender and trip motivation emerged as important moderating factors in the relationships among the latent constructs.Research limitations/implicationsThe findings of this paper enrich the existing literature and help tourism destination marketers and managers consider the triggering factors of a satisfying mega-sports event for the host destination and the marketing power of the on-site experience.Practical implicationsPractitioners should draw on the insights provided by this study to design destination strategies, particularly by paying attention to how an event experience causes an attendee to return to and recommend the host destination.Originality/valueThis study enriches the existing event literature in several ways. First, it emphasizes the importance of the event experience to the satisfaction level and willingness to return and recommend the host destination for a vacation, supporting the link between an event and its destination. Second, it provides a moderating analysis that offers new insights for marketing the event experience. It offers a multilevel model of mega-event tourism legacy, which opens up new avenues of research. Third, complementing the consumer-based analysis, this research includes the trend of visits (after 2013 to the present) to examine how a mega-sport event has brought about more postevent visits.
Pro-socially motivated interaction for knowledge integration in crowd-based open innovation
Authors: Sun Yao , Tuertscher Philipp , Majchrzak Ann , Malhotra Arvind 
Published: August 2020

PurposeThe purpose of this paper is to study how the online temporary crowd shares knowledge in a way that fosters the integration of their diverse knowledge. Having the crowd integrate its knowledge to offer solution-ideas to ill-structured problems posed by organizations is one of the desired outcomes of crowd-based open innovation because, by integrating others’ knowledge, the ideas are more likely to consider the many divergent issues related to solving the ill-structured problem. Unfortunately, the diversity of knowledge content offered by heterogeneous specialists in the online temporary crowd makes integration difficult, and the lean social context of the crowd makes extensive dialogue to resolve integration issues impractical. The authors address this issue by exploring theoretically how the manner in which interaction is organically conducted during open innovation challenges enables the generation of integrative ideas. The authors hypothesize that, as online crowds organically share knowledge based upon successful pro-socially motivated interaction, they become more productive in generating integrative ideas.Design/methodology/approachUsing a multilevel mixed-effects model, this paper analyzed 2,244 posts embedded in 747 threads with 214 integrative ideas taken from 10 open innovation challenges.FindingsIntegrative ideas were more likely to occur after pro-socially motivated interactions.Research limitations/implicationsIdeas that integrate knowledge about the variety of issues that relate to solving an ill-structured problem are desired outcomes of crowd-based open innovation challenges. Given that members of the crowd in open innovation challenges rarely engage in dialogue, a new theory is needed to explain why integrative ideas emerge at all. The authors’ adaptation of pro-social motivation interaction theory helps to provide such a theoretical explanation. Practitioners of crowd-based open innovation should endeavor to implement systems that encourage the crowd members to maintain a high level of activeness in pro-socially motivated interaction to ensure that their knowledge is integrated as solutions are generated.Originality/valueThe present study extends the crowd-based open innovation literature by identifying new forms of social interaction that foster more integrated ideas from the crowd, suggesting the mitigating role of pro-socially motivated interaction in the negative relationship between knowledge diversity and knowledge integration. This study fills in the research gap in knowledge management research describing a need for conceptual frameworks explaining how to manage the increasing complexity of knowledge in the context of crowd-based collaboration for innovation.
Third-country nationals as intercultural boundary spanners in multinational corporations
Authors: Barmeyer Christoph , Stein Volker , Eberhardt Jenny Marie 
Published: August 2020

PurposeThis paper aims to investigate the central roles, functions and competences of third-country nationals (TCNs) in intercultural boundary spanning in multinational corporations (MNCs): Why are TCNs particularly important for reducing complexity at the overlapping functional, geographic and external boundaries of MNCs with their related interferences and which role do they play as boundary spanners in cross-boundary collaboration?Design/methodology/approachAfter introducing the theoretical background on boundary spanning and TCNs, the methodology applied in this paper is a theory-driven, qualitative approach based on 13 in-depth semi-structured interviews with TNCs conducted in 10 MNCs.FindingsThe authors aggregate TCNs’ activities into four roles: disembedded cosmopolitan, intermediary, third party and team-related boundary spanner. They show that TCNs tend to understand the complex intercultural context between headquarters and subsidiaries, balance power asymmetries, use their in-between neutrality to create trust, and act in an interculturally highly competent way by using a great variety of intercultural and linguistic skills. The TCNs’ meta-competence permits a higher level, intellectual and abstract perspective, enabling TCNs to consider structures, objects and interactions from an affective distance.Research limitations/implicationsThe differences between TCNs and “regular” expatriates or other interface managers are examined and methodological limitations as well as research implications are critically discussed. MNCs can intentionally assign TCNs with their related competence profiles when expecting boundary-spanning tasks.Originality/valueThis paper is one of the few published that undergirds the TCN concept with empirical data and illustrates the suitability of specific role-takers such as TCNs for some complex challenges in international and intercultural management settings.
Impact of employee's political skill on abusive supervision: does gender matter?
Authors: Rizvi Fizza , Azam Akbar 
Published: August 2020

PurposeThe purpose of this research is to investigate if employees possessing good political skill face less abusive behavior from their supervisors. Moreover, the gender of the subordinate has been tested as a moderator between political skill and abusive supervision. Cultural and social factors prevailing in the research settings of Pakistan provide an ideal situation to test the relationship between political skill and abusive supervision.Design/methodology/approachThe data were collected from 178 employees representing different sectors of Pakistani industry. To test the relationship between political skill and abusive supervision, simple linear regression was run and moderation was tested using PROCESS macro.FindingsFrom the analysis, the major findings prove that political skill lessens abusive supervision. Moreover, due to the cultural settings, male subordinates use political skill more proficiently to avoid abusive supervision as compared to female subordinates.Practical implicationsThe study suggests that in order to maintain harmony in the work environment, employees must learn political skill to avoid abusive supervision. Moreover, females must be given more chances to utilize their political skill to get positive outcomes.Originality/valueThis study fills up a significant gap in the literature, as there is scarce literature available that investigates the relationship between political skill and abusive supervision, specifically in Pakistan.
AGING, DISABILITY, AND END‐OF‐LIFE
Authors: Fashaw S. , McCreedy E. , Thomas K. , Shireman T. 
Published: August 2020

Research ObjectivePreliminary research demonstrated an increase in the reporting of schizophrenia diagnoses among nursing home (NH) residents subsequent to the Centers for Medicare & Medicaid Services (CMS) National Partnership to Improve Dementia Care. Some researchers posit that as much as 20% of the reduction in inappropriate antipsychotic use could be explained by the changes in schizophrenia reporting. Given known health disparities and higher antipsychotic use for black NH residents, we examined how race and dementia influence the rate of schizophrenia diagnoses among NH residents. To date, no study uses a formal test, concurrently adjusting for relevant covariates, to examine trends in schizophrenia reporting following the National Partnership.Study DesignUsing a quasi‐experimental study design, we examined long‐stay NH residents’ quarterly and/or yearly Minimum Data Set (MDS) 3.0 assessments between 2011 and 2015. The main outcome variable was the presence of a schizophrenia diagnosis. Using a difference‐in‐difference analysis adjusting for independent variables, we examined the relationship before and after the partnership. Our independent variables were added to our unadjusted model in a stepwise fashion: 1) age, sex, and race; 2) diabetes and heart conditions indicating poor heart health; and finally, 3) activities of daily living and changes in health, end‐stage disease, and symptoms and signs scale scores.Population StudiedLong‐stay US NH residents.Principal FindingsThere were over 4 million MDS assessments annually. Schizophrenia reporting increased by 9.1% in the dementia group as compared to 9.9% in the nondementia group (P < 0.0001). Black residents had a significantly higher likelihood of schizophrenia reporting (4%, P < 0.0001). After controlling for covariates, there was a 16.7% increase in schizophrenia reporting for blacks with dementia and 14.6% increase for non‐blacks with dementia (P < .0001). There was no racial disparity identified among the nondementia group after controlling for covariates.ConclusionsBlack NH residents were more likely to have schizophrenia documented on their MDS assessments, and following the partnership to rein in antipsychotic medication use, schizophrenia reporting rates increased faster for blacks with dementia than their non‐black peers and their peers without dementia. Further work is needed to determine whether schizophrenia diagnoses are appropriately employed in NH practice, particularly for black Americans.Implications for Policy or PracticeResearchers and policy makers should consider race and socioeconomic status when examining the impact of new policies and practices. The 2012 National Partnership may have had unintended consequences that negatively impacted black NH residents with dementia. Additionally, controlling for relevant covariates is important for properly interpreting changes in diagnoses and potentially for measuring the changes in inappropriate antipsychotics.Primary Funding SourceThe study was funded by the Agency for Healthcare Research and Quality.