bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Brazilian Cohort of Patients With Immuno-Mediated Chronic Inflammatory Diseases Infected by SARS-CoV-2 (ReumaCoV-Brasil Registry): Protocol for a Prospective, Observational Study
Authors: Marques Claudia , Kakehasi Adriana Maria , Gomides Ana Paula Monteiro , Paiva Eduardo Dos Santos , dos Reis Neto Edgard Torres , Pileggi Gecilmara Cristina Salviato , Provenza José Roberto , Mota Licia , Xavier Ricardo Machado , Ferreira Gilda Aparecida , Pinheiro Marcelo Medeiros 
Published: November 2020

Background
Patients with immune-mediated rheumatic diseases (IMRD) are at increased risk of infections, including significant morbidity and high mortality. Considering the potential for unfavorable outcomes of SARS-CoV-2 infection in patients with IMRD, several questions were raised regarding the impact of COVID-19 at the start of the pandemic.

Objective
This paper presents the protocol of a study that aims to prospectively evaluate patients with IMRD and a confirmed COVID-19 diagnosis (using criteria provided by the Brazilian Ministry of Health).

Methods
The study comprised a prospective, observational cohort (patients with IMRD and COVID-19) and a comparison group (patients with only IMRD), with a follow-up time of 6 months to evaluate differences in health outcomes. The primary outcomes will be changes in IMRD disease activity after SARS-CoV-2 infection at 4 time points: (1) at baseline, (2) within 4-6 weeks after infection, (3) at 3 months after the second assessment (±15 days), and (4) at 6 months (±15 days). The secondary outcomes will be the progression rate to moderate or severe forms of COVID-19, need for intensive care unit admission and mechanical ventilation, death, and therapeutic changes related to IMRD. Two outcomes—pulmonary and thromboembolic events in patients with both IMRD and SARS-CoV-2 infection—are of particular interest and will be monitored with close attention (clinical, laboratory, and function tests as well as imaging).

Results
Recruitment opened in May 2020, with 1300 participants recruited from 43 sites as of November 2020. Patient recruitment will conclude by the end of December 2020, with follow-up occurring until April 2021. Data analysis is scheduled to start after all inclusion data have been collected, with an aim to publish a peer-reviewed paper in December 2020.

Conclusions
We believe this study will provide clinically relevant data on the general impact of COVID-19 on patients with IMRD.

Trial Registration
Brazilian Registry of Clinical Trials RBR-33YTQC; http://www.ensaiosclinicos.gov.br/rg/RBR-33ytqc/

International Registered Report Identifier (IRRID)
DERR1-10.2196/24357
Palliative splenic irradiation for symptomatic splenomegaly in chronic myelomonocytic leukemia − case report
Authors: Pires André , Rodrigues Isabel , Laranja André , Oliveira Ângelo , Gonçalves Joana 
Published: November 2020

Background:
Chronic myelomonocytic leukemia (CMML) is a rare malignant disorder that presents with splenomegaly in about 30% of cases.

Case presentation:
A 71-year-old man complained of abdominal pain, left hypochondrium distension, and weight loss. After work-up, a diagnosis of CMML was conducted, and the patient started chemotherapy. After about 2 years, he experienced clinical worsening compatible with symptomatic splenomegaly, and was proposed for radiotherapy. The patient underwent palliative splenic irradiation (SI), initially with 0.25 Gy fractions, delivered every other day, but the treatment was suspended after four fractions due to thrombocytopenia; 4 weeks later, the treatment was resumed, but was suspended again after 4 × 0.25 Gy fractions due to hematological changes. The patient was kept in palliative care and died 6 weeks later.

Conclusion:
SI has emerged as an alternative, widely used for palliation symptomatic splenomegaly in patients with hematological malignancies. This is the first report of SI for symptomatic splenomegaly on a patient with CMML.
Central Sensitization in Musculoskeletal Pain: Lost in Translation?
Authors: van Griensven Hubert , Schmid Annina , Trendafilova Teodora , Low Matthew 
Published: November 2020

Synopsis Central sensitization is a physiological mechanism associated with enhanced sensitivity and pain responses. At present, central sensitization cannot be determined directly in humans, but certain signs and symptoms may be suggestive of it. Although central sensitization has received increasing attention in the clinical literature, there is a risk that certain distinctions are being lost. This paper summarizes current knowledge of the physiology of central sensitization and its possible manifestations in patients, in order to inform a debate about the relevance of central sensitization for physical therapists. It poses 6 challenges associated with the application of central sensitization concepts in clinical practice and makes suggestions for assessment, treatment, and use of terminology. Physical therapists are asked to be mindful of central sensitization and consider potential top-down as well as bottom-up drivers, in the context of a person-centered biopsychosocial approach. J Orthop Sports Phys Ther 2020;50(11):592–596. doi:10.2519/jospt.2020.0610
The Effects of Exercise Dosage on Neck-Related Pain and Disability: A Systematic Review With Meta-analysis
Authors: Wilhelm Mark P. , Donaldson Megan , Griswold David , Learman Kenneth E. , Garcia Alessandra N. , Learman Shane M. , Cleland Joshua A. 
Published: November 2020

Objective To (1) evaluate whether exercise therapy is effective for managing neck pain, and (2) investigate the relationship between exercise therapy dosage and treatment effect. Design Intervention systematic review with meta-analysis and meta-regression. Literature Search An electronic search of 6 databases was completed for trials assessing the effects of exercise therapy on neck pain. Study Selection Criteria We included randomized controlled trials that compared exercise therapy to a no-exercise therapy control for treating neck pain. Two reviewers screened and selected studies, extracted outcomes, assessed article risk of bias, and rated the quality of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Data Synthesis Data were pooled using random-effects meta-analysis. We used meta-regression to analyze the effect of exercise dosage on neck pain and disability. Results Fourteen trials were included in the review. Seven trials were at high risk of bias, 4 were at unclear risk of bias, and 3 were at low risk of bias. Exercise therapy was superior to control for reducing pain (visual analog scale mean difference, −15.32 mm) and improving disability (Neck Disability Index mean difference, −3.64 points). Exercise dosage parameters did not predict pain or disability outcomes. Conclusion Exercise was beneficial for reducing pain and disability, regardless of exercise therapy dosage. Therefore, optimal exercise dosage recommendations remain unknown. We encourage clinicians to use exercise when managing mechanical neck pain. J Orthop Sports Phys Ther 2020;50(11):607–621. doi:10.2519/jospt.2020.9155
Validity of Clinical Measurement Instruments Assessing Scapular Function: Insufficient Evidence to Recommend Any Instrument for Assessing Scapular Posture, Movement, and Dysfunction—A Systematic Review
Authors: D'hondt Norman E. , Pool Jan J.M. , Kiers Henri , Terwee Caroline B. , Veeger (Dirkjan) H.E.J. 
Published: November 2020

Objective To determine the construct validity, criterion validity, and responsiveness of measurement instruments evaluating scapular function. Design Systematic review of measurement properties. Literature Search The MEDLINE, Embase, CINAHL, and SPORTDiscus databases were systematically searched from inception until March 2019. Study Selection Criteria Studies published in Dutch, English, or German were included when they evaluated at least 1 of the measurement properties of interest. No restrictions were made regarding participants' health status. Data Synthesis Two reviewers independently evaluated study quality using the COSMIN checklist and extracted and analyzed data. Quality of evidence was graded by measurement property for each distinctive type of measurement. Results Thirty-one measurement instruments in 14 studies were categorized into instruments to measure scapular posture and movement, and to assess scapular dyskinesis. Quality of evidence was at most moderate for 4 instruments with respect to criterion validity. Of these, criterion validity for instruments measuring scapular protraction/retraction posture and rotation angles up to 120° of thoracohumeral elevation was sufficient. Criterion validity for instruments measuring asymmetrical scapular posture, range of motion, and the lateral scapular slide test was insufficient. Quality of evidence for measurement properties of all other instruments was graded lower. Conclusion There is currently insufficient evidence to recommend any instrument for the clinical examination of scapular function. Measurement instruments to assess scapular dyskinesis are prone to misinterpretation and should therefore not be used as such. J Orthop Sports Phys Ther 2020;50(11):632–641. doi:10.2519/jospt.2020.9265
Do the Number of Visits and the Cost of Musculoskeletal Care Improve Outcomes? More May Not Be Better
Authors: Clewley Derek , Iftikhar Yusra , Horn Maggie E. , Rhon Daniel I. 
Published: November 2020

Objectives To determine the relationship between health care use and the magnitude of change in patient-reported outcomes in individuals who received treatment for subacromial pain syndrome. The secondary objective was to determine the value of care, as measured by change in pain and disability per dollar spent. Design Secondary analysis of a randomized clinical trial that investigated the effects of nonsurgical care for subacromial pain syndrome. Methods Two groups of treatment responders were created, based on 1-year change in Shoulder Pain and Disability Index (SPADI) score (high, 46.83 points; low, 8.21 points). Regression analysis was performed to determine the association between health care use and 1-year change in SPADI score. Baseline SPADI score was used as a covariate in the regression analysis. Value was measured by comparing health care visits and costs expended per SPADI 1-point change between responder groups. Results Ninety-eight patients were included; 38 were classified as high responders (mean 1-year SPADI change score, 46.83 points) and 60 were classified as low responders (1-year SPADI change score, 8.21 points). Neither unadjusted medical visits (5.89; 95% confidence interval [CI]: 4.35, 7.44 versus 6.30; 95% CI: 5.14, 7.46) nor medical costs ($1404.86; 95% CI: $1109.34, $1779.09 versus $1679.26; 95% CI: $1391.54, $2026.48) were significantly different between high and low responders, respectively. Conclusion Neither the number of visits nor the financial cost of nonsurgical shoulder- related care was associated with improvement in shoulder pain and disability at 1 year. J Orthop Sports Phys Ther 2020;50(11):642–648. doi:10.2519/jospt.2020.9440
The Effectiveness of Strategies to Promote Walking in People With Musculoskeletal Disorders: A Systematic Review With Meta-analysis
Authors: Saragiotto Bruno T. , Fioratti Iuri , Tiedemann Anne , Hancock Mark J. , Yamato Tiê P. , Wang Samuel S.Y. , Chau Josephine Y. , Lin Chung-Wei Christine 
Published: November 2020

Objective To evaluate the effect of walking promotion strategies on physical activity, pain, and function in people with musculoskeletal disorders. Design Intervention systematic review with meta-analysis. Literature Search We performed the searches in MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and the Physiotherapy Evidence Database (PEDro) from inception to August 2019. Study Selection Criteria We included randomized controlled trials evaluating interventions that promote walking in people with musculoskeletal disorders. Data Synthesis We used the PEDro scale for assessing risk of bias and the Grading of Recommendations Assessment, Development and Evaluation approach to evaluate the quality of evidence. We expressed pooled effects for between-group differences as mean differences or standardized mean differences and 95% confidence intervals, or as risk ratios and 95% confidence intervals, using random-effects meta-analyses. Results Twelve eligible trials (n = 1456 participants) were identified. There was moderate- to very low–quality evidence of no difference in physical activity levels for walking promotion interventions when compared to minimal interventions, and a significant effect favoring walking promotion when compared with usual care in the short term. There was moderate-quality evidence that walking promotion was modestly effective for reducing pain and improving function compared with minimal intervention and usual care. There was no difference in pain and function for walking promotion compared to supervised exercise. Walking promotion was not associated with different rates of adverse events compared to control conditions. Conclusion Strategies to promote walking did not increase physical activity in people with musculoskeletal disorders. Walking promotion was associated with small improvements in pain and function compared to minimal intervention and usual care. J Orthop Sports Phys Ther 2020;50(11):597–606. doi:10.2519/jospt.2020.9666
Identification of novel somatic cell-free DNA variants by next-generation sequencing in breast cancer patients
Authors: Raghu Aarthy , Balaiah Meenakumari , Veluswami Sridevi , Sundersingh Shirley , Thangarajan Rajkumar , Mani Samson 
Published: November 2020

Objectives:
Breast cancer is a heterogeneous disease affecting women worldwide and is one of the leading causes of mortality in India. Sampling bias due to tumor heterogeneity and invasive nature of biopsies necessitate noninvasive methods for comprehensive tumor profiling. Circulating cell-free DNA presents a complete mutation profile of the tumor, enabling the non-invasive monitoring of disease in real-time. This study aimed to identify tumor-specific variants in cfDNA with potential applications in the liquid-biopsy based testing of breast cancer.

Material and Methods:
Next-generation sequencing was performed for cell-free DNA, lymphocyte DNA, and tumor DNA from 21 breast cancer patients. Variant calling was performed using Torrent Suite Server v.5.0 and somatic variants were annotated using web-based tools. Pathogenic variants detected in cell-free DNA and tumor DNA of three patients were validated by Sanger sequencing.

Results:
Fifty-nine somatic variants were detected in the cell-free DNA of 10 breast cancer patients. Hotspot variants were detected in PIK3CA, TP53, and KRAS genes. In addition, previously unreported missense variants in ABL1 and PIK3CA genes were predicted to be pathogenic and potential driver mutations. Several frameshift indels were detected in two triple negative breast cancer patients.

Conclusion:
Sequencing of cell-free DNA from breast cancer patients identified somatic variants including several potentially pathogenic variants which have not been reported previously. These variants may have potential applications as non-invasive biomarkers for breast cancer.
Aplikasi Bentonite Lokal Terhadap Nilai Compressive dan Shear Bond Strength Suspensi Semen Sumur Minyak
Authors: Khalid Idham , Musnal Ali , Novriansyah Adi , Sitanggang Kurniawan 
Published: November 2020

[ID] Pelaksanaaan proses penyemenan yang baik pada sumur minyak merupakan aspek penting yang berpengaruh pada suskesnya produksi minyak ke permukaan. Untuk itu, penggunaan additif dalam suspense semen direkomendasikan supaya kulitas suspense semen tetap stabil selama proses penyemenan berlangsung. Melakui penelitian ini kualitas bentonite lokal dan bentonite komersial terhadap parameter compressive strength(CS) dan shear bond strength (SBS) akan dibandingkan. Pengukuran CS dan SBS dilkukan berdasarkan rekomendasi dari American Petroleum Institute (API) pada tujuh buah sampel suspense semen dengan konsentrasi aditif yang bervariasi. Hasil penelitian terhadap bentonite lokal menunjukkan penurunan nilai CS dengan bertambahnya konsentrasi aditif. Konsentrasi optimum bentonite lokal adalah 1.6% dengan nilai CS sebesar 1649 psi, 6% dibawah nilai CS untuk sampel suspense semen dan bentonite komersial pada konsentrasi yang sama. Untuk nilai SBS, konsentrasi optimum untuk aditif bentonite lokal adalah 4.8% dengan nilai SBS sebesar 439 psi, 21 % diatas nilai SBS untuk sampel semen dengan 4.8% bentonite komersial. Dari penentuan nilai CS dan SBS dapat disimpulkan bahwa penggunaan bentonite lokal dapat menjadi alternatif pengganti bentonite komersial dimana hasil pengukuran CS dan SBS tidak menunjukkan perbedaan yang signifikan.
[EN] The implementation of a good cementing process in oil wells is an important aspect that affects the success of oil production to the surface. For this reason, the use of additives in semen suspense is thought that the quality of the cement suspension remains stable during the cementing process. By doing this research, the quality of local bentonite and commercial bentonite against the parameters of compressive strength (CS) and shear bond strength (SBS) will be compared. CS and SBS measurements were carried out based on recommendations from the American Petroleum Institute (API) on seven cement suspension samples with varying additive concentrations. The results of research on local bentonite showed a decrease in the value of CS with an increase in additive concentration. The optimum concentration of local bentonite is 1.6% with a CS value of 1649 psi, 6% below the CS value for cement and commercial bentonite suspense samples at the same concentration. For the SBS value, the optimum concentration for local bentonite additives is 4.8% with an SBS value of 439 psi, 21% above the SBS value for cement samples with 4.8% commercial bentonite. From the determination of CS and SBS values, it can be shown that the use of local bentonite can be an alternative to commercial sites where the CS and SBS measurement results do not show a significant difference.
Evaluasi Kapasitas Elemen Struktur Eksisting Food Court Untuk Perencanaan Cinemaxx Mal Pekanbaru
Authors: Ardiansyah Rony 
Published: November 2020

[ID] Evaluasi Kapasitas Struktur Eksisting Area Food Court seluas 1024m2 yang dialihfungsikan sebagai Cinemaxx. Penelitian ini dimaksudkan untuk mengetahui kapasitas izin dari elemen struktur eksisting pada elemen balok dan pelat lantai dengan memberikan beban hidup beragam. Struktur dimodelkan dengan menggunakan bantuan program ETABS 2015 untuk menganalisis gaya dalam pada elemen balok. Sedangkan untuk menganalisis gaya dalam pada elemen pelat menggunakan bantuan program SAP 2015. Adapun area yang ditinjau pada evaluasi ini yaitu pelat lantai-3 As-J s/d As-R dan As-2 s/d As-5. Hasil evaluasi menunjukkan bahwa pelat lantai eksisting pada bentang X dengan dan tanpa memperhitungkan defleksi balok, dinyatakan aman (OK) untuk beban hidup 400 & 500 kg/m2, untuk beban hidup 600 kg/m2 dinyatakan KRITIS dan untuk beban hidup 700 kg/m2 dinyatakan tidak aman (NO-OK). Pada pelat lantai, pelat bentang Y hanya beban hidup 400 kg/m2 yang dinyatakan aman (OK), beban hidup 500 kg/m2 dinyatakan KRITIS, dan beban hidup 600 kg/m2 dinyatakan tidak aman (NO-OK). Pelat lantai tanpa memperhitungkan pengaruh defleksi dari balok sekelilingnya atau dengan asumsi pelat sebagai beban, untuk semua beban hidup nya mulai dari 400, 500 dan 600 kg/m2 dinyatakan aman (OK). Momen lentur balok induk 350 x 650 pada tumpuan dinyatakan aman (OK) untuk semua beban hidup mulai dari 500 kg/m2 s/d 800 kg/m2. Sedangkan area lapangan dinyatakan (OK) untuk beban hidup 500 & 600 kg/m2; untuk beban hidup 700 kg/m2 dinyatakan tidak aman (NO-OK).
[EN] The evaluation of existing food court structural capacity with area size 1024m2 planned to be transformed to Cinemax. This research is purposed to determine permit capacity of existing structural elements on the beam and slab elements by providing various live loads. The structure is modeled using the ETABS 2015 program to analyze the internal forces on the beam elements. Then to analyze forces within slabs structures were modeled using the SAP 2015. The area covered in this evaluation is the floor slab-3 column centre J-R, and 2-5. The evaluation show for floor slab case in x-axis span, ignoring deflection of the beam, in response to 400 - 500 kg/m2 live load is considered to be safe (OK), 600 kg/m2 live load is considered to be critical, 700 kg/m2 live load is cosidered to be unsafe (NO-OK). In y-axis span, in response to 400 kg/m2 live load, it is considered safe (OK), 500 kg/m2 live load is considered critical, 600 kg/m2 live load is considered unsafe (NO-OK). All slabs assumed as its sole load without putting beam deflection into equation are considered safe in response to 500 - 600 kg/m2 live load. For main beams case (350x650), bending moment in support section is considered to be safe (OK) in all case of live load ranging from 500 - 800 kg/m2. While bending moment in midspan section, in response to 500-600 kg/m2 live load is considered to be safe (OK), 700 kg/m2 live load is considered to be unsafe (NO-OK).
Implementasi Promosi Kesehatan untuk Menurunkan Kasus Stunting di Wilayah Kerja Puskesmas Darajuanti Kabupaten Sintang
Authors: Komala Dewi Ria Risti , Putra Gandha Sunaryo 
Published: November 2020

Abstrak: Puskesmas Dara Juanti menduduki peringkat pertama dengan kasus stunting tertinggi di Kecamatan Sintang dengan angka kejadian sebesar 26,62 % pada Tahun 2016, mengalami peningkatan sebesar 27,02% pada tahun 2017, dan pada tahun 2018 turun menjadi 22,79%. Walaupun kasus stunting mengalami penurunan, akan tetapi kasus stunting maksimal yang dipersyaratkan oleh World Health Organization (WHO) adalah 20%. Permasalahan yang terjadi di wilayah kerja Puskesmas Darajuanti yaitu belum dilakukannya program intervensi yang efektif terhadap kasus stunting khususnya peningkatan pemahaman akan pentingnya asupan gizi dan cara pengasuhan yang benar pada ibu yang memiliki balita. Adapun solusi yang akan dilaksanakan dalam rangka penyelesaian masalah diatas adalah peningkatan pengetahuan melalui penyuluhan tentang gizi balita dan praktik pemberian makan pada balita di Wilayah Kerja Puskesmas Darajuanti. Tujuan dan target khusus yang ingin dicapai dari kegiatan ini adalah meningkatkan pengetahuan ibu balita tentang pentingnya asupan gizi dan cara pengasuhan yang benar pada balitanya serta peningkatan pengetahuan tentang bahaya stunting. Kegiatan dilaksanakan pada tanggal 12 September 2020 di posyandu Ulak Jaya. Metode pelaksanaan yang digunakan dalam pengabdian ini adalah sosialisasi, penyuluhan, dan pelatihan. Hasil kegiatan juga menunjukkan bahwa terdapat perbedaan yang bermakna tingkat pengetahuan responden sebelum dan sesudah dilaksanakan penyuluhan (p value=0,00).
PERBANDINGAN MODEL PEMBELAJARAN TIPE TALKING STICK DAN MIND MAPPING TERHADAP KEMAMPUAN MATEMATIKA SISWA
Authors: Pantriyastuti Riska , Nafi'an Muhammad Ilman , Ana Ria Fajrin Rizky 
Published: November 2020

<em>Tujuan penelitian ini adalah untuk mengetahui 1) Apakah terdapat perbedaan kemampuan matematis antara siswa yang menggunakan model pembelajaran tipe Talking Stick dan model pembelajaran tipe Mind Mapping pada siswa kelas VIII di MTs Negeri Tunggangri Tahun Pelajaran 2016/2017. Metode penelitian adalah menggunakan penelitian kuantitatif kelas eksperimen. Validitas instrumen tes dengan cara mengkorelasikan antara skor item dengan rumus Pearson Product Moment, Validitas instrumen dengan cara reliabilitas digunakan rumus Alpha. Analisis data dengan uji keseimbangan, uji prasarat, dan uji hipotesis. Hasil dari penelitian diperoleh bahwa t<sub>hitung</sub> ? t<sub>tabel</sub> yaitu 6,566 ? 1,991 yang berarti bahwa H ditolak dan H<sub>1</sub> diterima. Ini berarti bahwa kemampuan matematika siswa kelas kontrol lebih baik daripada kelas eksperimen. Kesimpulan dari penelitian ini adalah (1) Terdapat perbedaan kemampuan matematis antara siswa yang menggunakan model pembelajaran tipe Talking Stick dan Mind Mapping pada siswa kelas VIII di MTs Negeri Tunggangri Tahun Pelajaran 2016/2017.</em>