bluuebunny/crossref_metadata_2025_split huggingface dataset:
Choice of style solution for a design project
Authors: Khristoforova I V , Krasikova T I , Silcheva L V , Sorokotyagina E N 
Published: October 2020

Abstract
The publication reveals the role of marketing research in the choice of style solutions for design concepts in educational institutions. The results of the analysis of styles used in the design concepts of educational institutions, conducted with the involvement of 159 analog objects, are presented. The problem of conflict between the creative and technological components in the design profession is discussed. The role of the digital component in the effectiveness of work on a design project is emphasized. The list of popular professional computer programs used in the course of design engineering. Based on these programs, the student project presented as an example was executed. Discussed issues of digitization of design in conjunction with the assessment of the author’s contribution and the impact of the creativity of a particular designer
Using computer graphics in design
Authors: Shopina E V , Stativko A A , Markova M A 
Published: October 2020

Abstract
In the modern world, with the development of technology, it becomes possible to create design art objects from the developed sketch to the implementation of the project in material using computer graphics. Thanks to vector graphics programs and the emergence of laser and milling equipment with numerical software (CNC), designers were able to transfer the drawing to the material using material cutting technology. The object of the study is vector graphics programs, laser and milling cutting technology. As a result of the study, the authors conclude that thanks to software products and the development of technologies and equipment, designers were able to simplify the process of making decorative products.
Features of style shaping in modern design
Authors: Vasilenko E V , Vasilenko P G , Gordeeva T A , Gerasimenko I I 
Published: October 2020

Abstract
The article is devoted to the analysis of modern design, features of style formation and conceptual solutions in design. The dynamics of social development of our society, energy interactions, flows and mixing of social, cultural, aesthetic layers and groups contribute to an even greater variety of styles in the modern household environment. Eclecticism - free variation of images of any of the historical styles, their arbitrary combination, adaptation to needs-becomes the main feature of modern design. The organization opposes the desire for unlimited freedom of expression, from collectivism to individualism. Despite all the complexity and multilayered style-forming factors, in the end, the style is a system of externally perceived and easily recognizable features. Recent trends in design and world art are not at all without roots in the past and do not represent a decisive break with them. The use of retro style, pop art, hyperrealism and abstraction in design is generated by a modern over-urbanized culture. Modern style is a complex system of interactions in a single process of spiritual development of society. It can be understood as a conclusion, as a generalization of real experience. The existence of a single modern style with its unity of forms, features and attributes is impossible. Modern style formation involves the combination of different directions.
How Long-Term Acute Care Hospitals Can Play an Important Role in Controlling Carbapenem-Resistant Enterobacteriaceae in a Region: A Simulation Modeling Study
Authors: Lee Bruce Y , Bartsch Sarah M , Lin Michael Y , Asti Lindsey , Welling Joel , Mueller Leslie E , Leonard Jim , Brown Shawn T , Doshi Kruti , Kemble Sarah K , Mitgang Elizabeth A , Weinstein Robert A , Trick William E , Hayden Mary K 
Published: October 2020

Abstract
Typically, long-term acute care hospitals (LTACHs) have less experience in and incentives to implementing aggressive infection control for drug-resistant organisms such as carbapenem-resistant Enterobacteriaceae (CRE) than acute care hospitals. Decision makers need to understand how implementing control measures in LTACHs can impact CRE spread regionwide. Using our Chicago metropolitan region agent-based model to simulate CRE spread and control, we estimated that a prevention bundle in only LTACHs decreased prevalence by a relative 4.6%–17.1%, averted 1,090–2,795 new carriers, 273–722 infections and 37–87 deaths over 3 years and saved $30.5–$69.1 million, compared with no CRE control measures. When LTACHs and intensive care units intervened, prevalence decreased by a relative 21.2%. Adding LTACHs averted an additional 1,995 carriers, 513 infections, and 62 deaths, and saved $47.6 million beyond implementation in intensive care units alone. Thus, LTACHs may be more important than other acute care settings for controlling CRE, and regional efforts to control drug-resistant organisms should start with LTACHs as a centerpiece.
Computational strategies to combat COVID-19: useful tools to accelerate SARS-CoV-2 and coronavirus research
Authors: Hufsky Franziska , Lamkiewicz Kevin , Almeida Alexandre , Aouacheria Abdel , Arighi Cecilia , Bateman Alex , Baumbach Jan , Beerenwinkel Niko , Brandt Christian , Cacciabue Marco , Chuguransky Sara , Drechsel Oliver , Finn Robert D , Fritz Adrian , Fuchs Stephan , Hattab Georges , Hauschild Anne-Christin , Heider Dominik , Hoffmann Marie , Hölzer Martin , Hoops Stefan , Kaderali Lars , Kalvari Ioanna , von Kleist Max , Kmiecinski Renó , Kühnert Denise , Lasso Gorka , Libin Pieter , List Markus , Löchel Hannah F , Martin Maria J , Martin Roman , Matschinske Julian , McHardy Alice C , Mendes Pedro , Mistry Jaina , Navratil Vincent , Nawrocki Eric P , O’Toole Áine Niamh , Ontiveros-Palacios Nancy , Petrov Anton I , Rangel-Pineros Guillermo , Redaschi Nicole , Reimering Susanne , Reinert Knut , Reyes Alejandro , Richardson Lorna , Robertson David L , Sadegh Sepideh , Singer Joshua B , Theys Kristof , Upton Chris , Welzel Marius , Williams Lowri , Marz Manja 
Published: October 2020

Abstract
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel virus of the family Coronaviridae. The virus causes the infectious disease COVID-19. The biology of coronaviruses has been studied for many years. However, bioinformatics tools designed explicitly for SARS-CoV-2 have only recently been developed as a rapid reaction to the need for fast detection, understanding and treatment of COVID-19. To control the ongoing COVID-19 pandemic, it is of utmost importance to get insight into the evolution and pathogenesis of the virus. In this review, we cover bioinformatics workflows and tools for the routine detection of SARS-CoV-2 infection, the reliable analysis of sequencing data, the tracking of the COVID-19 pandemic and evaluation of containment measures, the study of coronavirus evolution, the discovery of potential drug targets and development of therapeutic strategies. For each tool, we briefly describe its use case and how it advances research specifically for SARS-CoV-2. All tools are free to use and available online, either through web applications or public code repositories. Contact:evbc@unj-jena.de
Coupled co-clustering-based unsupervised transfer learning for the integrative analysis of single-cell genomic data
Authors: Zeng Pengcheng , Wangwu Jiaxuan , Lin Zhixiang 
Published: October 2020

AbstractUnsupervised methods, such as clustering methods, are essential to the analysis of single-cell genomic data. The most current clustering methods are designed for one data type only, such as single-cell RNA sequencing (scRNA-seq), single-cell ATAC sequencing (scATAC-seq) or sc-methylation data alone, and a few are developed for the integrative analysis of multiple data types. The integrative analysis of multimodal single-cell genomic data sets leverages the power in multiple data sets and can deepen the biological insight. In this paper, we propose a coupled co-clustering-based unsupervised transfer learning algorithm (coupleCoC) for the integrative analysis of multimodal single-cell data. Our proposed coupleCoC builds upon the information theoretic co-clustering framework. In co-clustering, both the cells and the genomic features are simultaneously clustered. Clustering similar genomic features reduces the noise in single-cell data and facilitates transfer of knowledge across single-cell datasets. We applied coupleCoC for the integrative analysis of scATAC-seq and scRNA-seq data, sc-methylation and scRNA-seq data and scRNA-seq data from mouse and human. We demonstrate that coupleCoC improves the overall clustering performance and matches the cell subpopulations across multimodal single-cell genomic datasets. Our method coupleCoC is also computationally efficient and can scale up to large datasets.Availability: The software and datasets are available at https://github.com/cuhklinlab/coupleCoC.
The role of the south-western Alps as a unidirectional corridor for Mediterranean brown trout (Salmo truttacomplex) lineages
Authors: Splendiani Andrea , Berrebi Patrick , Tougard Christelle , Righi Tommaso , Reynaud Nathalie , Fioravanti Tatiana , Lo Conte Paolo , Delmastro Giovanni B , Baltieri Marco , Ciuffardi Luca , Candiotto Alessandro , Sabatini Andrea , Caputo Barucchi Vincenzo 
Published: October 2020

AbstractThe role of the south-western Alps as a corridor for Mediterranean trout (Salmo trutta complex Linnaeus, 1758) was evaluated in order to understand the influence of the last glacial events in shaping the spatial distribution of the genetic diversity of this salmonid. For this, the allochthonous hypothesis of a man-mediated French origin (19th century) of the Mediterranean trout inhabiting the Po tributaries in the Italian side of the south-western Alps was tested. A total of 412 individuals were analysed at the mitochondrial control region. The phylogenetic classification was carried out by using a Median-Joining Network analysis. Mismatch pair-wise analysis, molecular dating and Kernel density distribution analysis of the main mitochondrial lineages were evaluated to compare past demographic dynamics with the current spatial distribution of genetic diversity. The main outcomes resulted strongly in agreement with a biogeographic scenario where the south-western Alps acted as a unidirectional corridor that permitted the colonization of the upper Durance (Rhône River basin) by trout from the Po River basin. Therefore, the Mediterranean trout should be considered as native also along the Italian side of the south-western Alps and the allochthonous hypothesis should be rejected.
Exploring Peer Support as a Strategy to Reduce Self-Stigma for Marginalised Children of Parents with Mental Illness (COPMI)
Authors: Parkinson Adele , Keddell Emily , Walker Peter 
Published: October 2020

Abstract
Many children of parents with mental illness (COPMI) experience stigma, resulting in detrimental effects and the need for support. Peer support programmes are widespread interventions, commonly providing relational, psychological and educational support. Some evidence suggests that these programmes result in positive changes to COPMI experiences of self, peers and their families. This article adds to the evidence base, presenting findings from a primarily qualitative, mixed-methods programme evaluation of a COPMI service in Aotearoa/New Zealand. Formative evaluation data were gathered from a COPMI service which supports families adversely affected by chronic and severe parental mental illness, via interviews (N = 10) and four age-differentiated focus groups (N = 24) of child/youth service-users aged eight to eighteen years, and mixed-method surveys of adult service-users (N = 32). This article reports data from child/youth service-users who participated. Findings indicate that many participants experienced stigma outside the service, and self-stigma was reduced for many due to supportive peer relationships formed during service delivery. Further understanding of the relationship between peer support and self-stigma in these programmes is needed, and how positive changes to self-perceptions might translate to other spheres. The application of socio-ecological resilience theory to findings implies that COPMI service delivery should address differential needs in relation to marginalisation and promote sustained peer relationships for those who are marginalised.
Dopamine D2R is Required for Hippocampal-dependent Memory and Plasticity at the CA3-CA1 Synapse
Authors: Espadas Isabel , Ortiz Oscar , García-Sanz Patricia , Sanz-Magro Adrián , Alberquilla Samuel , Solis Oscar , Delgado-García José María , Gruart Agnès , Moratalla Rosario 
Published: October 2020

Abstract
Dopamine receptors play an important role in motivational, emotional, and motor responses. In addition, growing evidence suggests a key role of hippocampal dopamine receptors in learning and memory. It is well known that associative learning and synaptic plasticity of CA3-CA1 requires the dopamine D1 receptor (D1R). However, the specific role of the dopamine D2 receptor (D2R) on memory-related neuroplasticity processes is still undefined. Here, by using two models of D2R loss, D2R knockout mice (Drd2−/−) and mice with intrahippocampal injections of Drd2-small interfering RNA (Drd2-siRNA), we aimed to investigate how D2R is involved in learning and memory as well as in long-term potentiation of the hippocampus. Our studies revealed that the genetic inactivation of D2R impaired the spatial memory, associative learning, and the classical conditioning of eyelid responses. Similarly, deletion of D2R reduced the activity-dependent synaptic plasticity in the hippocampal CA1-CA3 synapse. Our results demonstrate the first direct evidence that D2R is essential in behaving mice for trace eye blink conditioning and associated changes in hippocampal synaptic strength. Taken together, these results indicate a key role of D2R in regulating hippocampal plasticity changes and, in consequence, acquisition and consolidation of spatial and associative forms of memory.
Clinical benefits of a swallowing intervention for esophageal cancer patients after esophagectomy
Authors: Takatsu Jun , Higaki Eiji , Hosoi Takahiro , Yoshida Masahiro , Yamamoto Masahiko , Abe Tetsuya , Shimizu Yasuhiro 
Published: October 2020

SummaryDysphagia after esophagectomy is the main cause of a prolonged postoperative stay. The present study investigated the effects of a swallowing intervention led by a speech–language–hearing therapist (SLHT) on postoperative dysphagia. We enrolled 276 consecutive esophageal cancer patients who underwent esophagectomy and cervical esophagogastric anastomosis between July 2015 and December 2018; 109 received standard care (control group) and 167 were treated by a swallowing intervention (intervention group). In the intervention group, swallowing function screening and rehabilitation based on each patient’s dysfunction were led by SLHT. The start of oral intake, length of oral intake rehabilitation, and length of the postoperative stay were compared in the two groups. The patient’s subgroups in the 276 patients were examined to clarify the more effectiveness of the intervention. The start of oral intake was significantly earlier in the intervention group (POD: 11 vs. 8 days; P = 0.009). In the subgroup analysis, the length of the postoperative stay was also significantly shortened by the swallowing intervention in patients without complications (POD: 18 vs. 14 days; P = 0.001) and with recurrent laryngeal nerve paralysis (RLNP) (POD: 30 vs. 21.5 days; P = 0.003). A multivariate regression analysis identified the swallowing intervention as a significant independent factor for the earlier start of oral intake and a shorter postoperative stay in patients without complications and with RLNP. Our proposed swallowing intervention is beneficial for the earlier start of oral intake and discharge after esophagectomy, particularly in patients without complications and with RLNP. This program may contribute to enhanced recovery after surgery.
Marked Absences: Locating Gender and Race in International Legal History
Authors: Nijman Janne E 
Published: October 2020

Abstract
This article was sparked by a critical reading of Henri de Waele’s article ‘A New League of Extraordinary Gentlemen? The Professionalization of International Law Scholarship in the Netherlands, 1919–1940’, and aims to offer an alternative perspective on this period in the history of Dutch international legal scholarship. While it appreciates the author’s examination of Dutch international law scholarship during the interwar period and concurs with the idea that this scholarship needs to be examined more closely, it argues that doing history today requires us first to raise ‘the woman question’, especially in the context of the so-called ‘professionalization’ of international law in the 1920s and 1930s, and second to include Dutch colonialism as an important backdrop to the work of the interwar international law scholars. I will give some pointers and illustrations to support this argument. The specific Dutch material brought to bear aims to show more generally the importance of questioning rather than reproducing traditional historiography, within which ‘the woman question’ and ‘the colonial question’ were left unmentioned. As such this article also deals with the issue of expanding and remaking international legal history as an issue of present and future purport.
Accuracy of an automated method of 3D soft tissue landmark detection
Authors: Baksi Sanjana , Freezer Simon , Matsumoto Takeshi , Dreyer Craig 
Published: October 2020

Summary

Introduction
Due to technological advances, the quantification of facial form can now be done via three-dimensional (3D) photographic systems such as stereophotogrammetry. To enable comparison with traditional cephalometry, soft-tissue anatomical landmark definitions have been modified to incorporate the third dimension. Annotating these landmarks manually, however, is still a time-consuming and arduous process.

Objective
To develop an automated algorithm to accurately identify anatomical landmarks on three-dimensional soft tissue images.

Methods
Thirty 3dMD images were selected from a private orthodontic practice consisting of 15 males and 15 females between 9 and 17 years of age. The soft-tissue 3D images were aligned along a reference plane to setup a Cartesian coordinate system. Screened by 2 observers, 21 landmarks were manually annotated and their coordinates defined. An automated landmark identification algorithm, based on their anatomical definitions, was developed to compare the landmark validity against the manually identified counterpart.

Results
Twenty-one landmarks were analysed in detail. Inter-observer and intra-observer reliability using ICC was &gt;0.9. The average difference and standard deviation between manual and automated methods for all landmarks was 3.2 and 1.64 mm, respectively. Sixteen out of twenty-one landmarks had a mean difference less than 4 mm. The landmarks of greatest agreement (≤2 mm) were mainly in the midline: pronasale, subnasale, subspinale, labiale superius, stomion, with the exception of chelion right. Five linear facial measurements were found to have moderate to good agreement between the manual and automated identification methods.

Conclusions
The developed algorithm was determined to be clinically relevant in the detection of midsagittal landmarks and associated measurements within the studied sample of adolescent Caucasian subjects.
Attitudes of medical students to general practice: a multinational cross-sectional survey
Authors: Avian Alexander , Poggenburg Stephanie , Schaffler-Schaden Dagmar , Hoffmann Kathryn , Sanftenberg Linda , Loukanova Svetla , Bachler Herbert , Gehrke-Beck Sabine , Petek Ster Marija , Becker Annette , Herrmann Markus , Frese Thomas , Gerlach Ferdinand , Zelko Erika , Flamm Maria , Roos Marco , Freitag Michael , Schirgi Julia , Rieder Anita , Siebenhofer Andrea 
Published: October 2020

Abstract

Background
A shortage of general practitioners (GPs) is common to many European countries. To counteract this, it is essential to understand the factors that encourage or discourage medical students from choosing to become a GP

Objective
To evaluate medical students’ attitudes towards general practice and to identify factors that discourage them from considering a career as a GP.

Methods
In this multinational cross-sectional online survey, 29 284 students from nine German, four Austrian and two Slovenian universities were invited to answer a questionnaire consisting of 146 closed and 13 open-ended items.

Results
Of the 4486 students that responded (response rate: 15.3%), 3.6% wanted to become a GP, 48.1% were undecided and 34.6% did not want to be a GP. Significant predictors for interest in becoming a GP were higher age [odds ratio (OR) = 1.06; 95% confidence interval (CI) = 1.02–1.10], positive evaluation of the content of a GP’s work (OR = 4.44; 95% CI = 3.26–6.06), organizational aspects (OR = 1.42; 95% CI = 1.13–1.78), practical experience of general practice (OR = 1.66; 95% CI = 1.08–2.56) and the country of the survey [Slovenian versus German students (Reference): OR = 2.19; 95% CI = 1.10–4.38; Austrian versus German students (Reference): OR = 0.50; 95% CI = 0.32–0.79].

Conclusion
Strategies to convince undecided students to opt for a career as a GP should include a positive representation of a GP’s work and early and repeated experience of working in a general practice during medical school.
“A Toxic Trend?”: Generational Conflict and Connectivity in Twitter Discourse Under the #BoomerRemover Hashtag
Authors: Sipocz Daniel , Freeman Jessica D , Elton Jessica 
Published: October 2020

AbstractBackground and ObjectivesThis study examines the #BoomerRemover hashtag on Twitter to understand discourses of intergenerational conflict and unity that emerged during the novel coronavirus disease 2019 global pandemic. The research highlights conflict and connection surrounding generational cohorts via social media, particularly in a time of crisis.Research Design and MethodsThe study used an inductive-dominant qualitative content analysis to examine 536 tweets collected between March 9 and April 9, 2020 under #BoomerRemover.ResultsData analysis revealed five forms of conflictive generational discourse: derogatory endorsement of the #BoomerRemover moniker, conflict regarding the nature and origins of the moniker, conflict surrounding the virus, political conflict, and generational jabs. Two forms of intergenerationally unifying discourse were identified: implicit and explicit pleas for connectivity.Discussion and ImplicationsThe analysis of discourse under #BoomerRemover revealed more nuanced expressions surrounding generational cohorts than widely reported in media outlets. Some users tweeted the hashtag in ways that reflected conflict, with #BoomerRemover acting as a vector through which stereotypes were perpetuated and magnified. However, a number of users tweeted the hashtag to call for intergenerational connectivity, highlighting the complexity of online discourse. These results yield implications for the study of online generational discourse, particularly in light of the unique circumstances surrounding the pandemic.