bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disordered eating attitudes among Iranian university students of medical sciences: The role of body image perception
Authors: Momeni Maryam , Ghorbani Azam , Arjeini Zahra 
Published: April 2020

Background: Disordered eating attitudes and behaviors have become an issue of worldwide concern. Aim: This research was designed to investigate the role of body image satisfaction in the relationship with eating attitudes among students of Qazvin University of Medical Sciences in Iran. Methods: In this cross-sectional study, 385 Qazvin university students of medical sciences were recruited by randomized stratified sampling in 2014. The students completed a three-part questionnaire (socio-demographic, Eating Attitudes Test and Body Shape Questionnaire) in their classrooms. We used hierarchical generalized linear models to identify variables significantly associated with Eating Attitudes Test scores. Results: The mean age of the students was 21.80 ± 2.98 years. Mean scores for the Eating Attitudes Test and Body Shape Questionnaire were 66.75 ± 29.8 and 11.86 ± 10.97 respectively; 18.5% of students had a score of 20 and above (≥ 20) that indicated disordered eating attitudes or as being at risk of eating disorders. In the multiple regression model, the Eating Attitudes Test was related to screening body image dissatisfaction (β = 0.122, P < 0.001). Body mass index was negatively related to the Eating Attitudes Test score (β= -0.488, P < 0.016), and diet was significantly correlated with an increased Eating Attitudes Test score (β = 5.803, P < 0.001). Conclusions: The risk of eating disorders is relatively high among Iranian university students. It can be a warning to health policy makers and should be the focus of special attention. In the present study, the most important factor related to abnormal eating attitudes was body image dissatisfaction. Regarding the complexity of the causes of eating disorders, various preventive and therapeutic interventions are necessary to avoid the dissemination in society of an idealized view of excessive thinness and further unfavorable outcomes in college students.
Transplantation of Endothelial Progenitor Cells in the Treatment of Coronary Artery Microembolism in Rats
Authors: Xue Yajun , Zhou Boda , Wu Jian , Miao Guobin , Li Kun , Li Siyuan , Zhou Jie , Geng Yu , Zhang Ping 
Published: April 2020

As the impairment of myocardial microenvironments due to coronary microembolization (CME) compromises the treatment effect of percutaneous coronary intervention and leads to adverse prognosis, we hypothesized that endothelial progenitor cells (EPCs) transplantation could improve cardiac function in the condition of CME. Low- (2 × 105) and high- (2 × 106) dose rat bone marrow-derived EPCs were transplanted in a model of CME. To develop a CME model, rats were injected with autologous micro-blood-clots into the left ventricle. Echocardiograph was examined before and 1, 7, and 28 days after EPC transplantation; serum cardiac troponin I (cTNI), von Willebrand factor (vWF), and cardiac microRNA expression were examined one day after EPCs transplantation. Heart morphology and vascular endothelial growth factor (VEGF), vWF, and basic fibroblast growth factor (bFGF) expression were examined one day after EPC transplantation. After 10 days of culture inductions, BM-EPCs have high purity as confirmed by flow cytometry. Cardiac function reflected by left ventricular ejection fraction significantly decreased after CME treatment and rescued by low-dose EPC. Compared to the sham group, cTNI and vWF serum levels increased significantly after CME treatment and rescued by low-dose EPC and high-dose EPC. Low-dose EPC treatment decreased myocardial necrosis and fibrosis and elevated cardiac expression of VEGF and vWF, while decreasing the cardiac expression of bFGF. Low-dose EPC treatment significantly suppressed cardiac expression of microRNA-19a but significantly enhanced microRNA-21, microRNA-214, and microRNA-486-3p expression. In conclusion, our results indicate that low-dose EPC transplantation may play a proangiogenic, antifibroblast, antifibrosis, and antinecrosis role and enhance cardiac function in a rat model of CME through a microRNA-related pathway.
A Novel Interprofessional Palliative Care and Geriatrics Curriculum for Nephrology Teams
Authors: Fulton Ana Tuya , Richman Katherine , Azar Maroun , Sanzen Kelley , Devine Jessica , Ferrone Christine , Tanzer Joshua Ray , Lally Kate 
Published: April 2020

Background: The population of older adults with chronic kidney disease (CKD) is increasing and nephrologists need education on the principles of geriatrics and palliative care to effectively care for this population. Objectives: Our objective was to develop and deliver a curriculum to interprofessional clinicians caring for older adults with CKD. The aim of this curriculum would be to improve knowledge of the principles of geriatrics and palliative care. Design: We have previously developed a curriculum on geriatrics and palliative care targeted toward primary care teams. In this project, we used an interdisciplinary steering committee to modify the curriculum for nephrology teams. Setting: This curriculum was delivered in a live grand rounds setting and was recorded and made available via online platform for virtual learning. Participants: The 6-session curriculum was delivered to 611 live and online learners between January 2018 and April 2019, with more than half of the participants (n = 317) completing more than 1 session. Participants came from a variety of disciplines including medicine, nursing, pharmacy, and social work. Results: Participants had a high rate of agreement with the statement that the curriculum met learning objectives, with live participants having stronger agreement. Participants reported that the activity would change their practice behavior by calling palliative care earlier, as well as improving their communication skills. Conclusion: Interprofessional collaboration can result in improved learning around the management of patients with CKD or end-stage kidney disease.
Analysis of the Intrinsic Predictors of Oronasal Fistula in Primary Cleft Palate Repair Using Intravelar Veloplasty
Authors: Yi Chang Ryul , Kang Min Kyu , Oh Tae Suk 
Published: April 2020

Introduction: The purpose of the present study was to investigate various factors of cleft palate and to analyze their effect on fistula occurrence following palatal muscle repair using intravelar veloplasty. Methods: A retrospective review of patients who underwent palatoplasty was performed. Primary palatoplasty was performed by a single surgeon in a single center. A total of 165 patients who underwent palatoplasty were enrolled. Primary palatoplasty with levator veli palatini muscle repair using intravelar veloplasty was performed. Three extrinsic factors (age, gender, and body weight) and 6 intrinsic factors (cleft width, ratio of cleft width to intermaxillary tuberosity distance, cleft anterior margin shape, uvula position, cleft lip, and radical intravelar veloplasty) were analyzed. Results: Palatal fistula occurred in 11 (6.67%) patients. The occurrence of fistula was significantly correlated with a specific Veau classification, that is, type II ( P = .041). Fistula tended to occur more frequently with a wide cleft palate ( P = .063), and the high-risk cutoff value of the width was 7.75 mm. Conclusions: A larger cleft width tended to increase the occurrence of fistula. Close observation and information about the higher risk of fistula formation should be given to patients with a large cleft width who underwent intravelar veloplasty.
Structural integrity of white matter tracts as a predictor of acute ischemic stroke outcome
Authors: Rajashekar Deepthi , Mouchès Pauline , Fiehler Jens , Menon Bijoy K , Goyal Mayank , Demchuk Andrew M , Hill Michael D , Dukelow Sean P , Forkert Nils D 
Published: April 2020

Background and purpose Clinical assessment scores in acute ischemic stroke are only moderately correlated with lesion volume since lesion location is an important confounding factor. Many studies have investigated gray matter indicators of stroke severity, but the understanding of white matter tract involvement is limited in the early phase after stroke. This study aimed to measure and model the involvement of white matter tracts with respect to 24-h post-stroke National Institutes of Health Stroke Scale (NIHSS). Material and methods A total of 96 patients (50 females, mean age 66.4 ± 14.0 years, median NIHSS 5, interquartile range: 2–9.5) with follow-up fluid-attenuated inversion recovery magnetic resonance imaging data sets acquired one to seven days after acute ischemic stroke onset due to proximal anterior circulation occlusion were included. Lesions were semi-automatically segmented and non-linearly registered to a common reference atlas. The lesion overlap and tract integrity were determined for each white matter tract in the AALCAT atlas and used to model NIHSS outcomes using a supervised linear-kernel support vector regression method, which was evaluated using leave-one-patient-out cross validation. Results The support vector regression model using the tract integrity and tract lesion overlap measurements predicted the 24-h NIHSS score with a high correlation value of r = 0.7. Using the tract overlap and tract integrity feature improved the modeling accuracy of NIHSS significantly by 6% (p < 0.05) compared to using overlap measures only. Conclusion White matter tract integrity and lesion load are important predictors for clinical outcome after an acute ischemic stroke as measured by the NIHSS and should be integrated for predictive modeling.
Association between platelet count and osteoarthritis in women older than 50 years
Authors: Kwon Yu-Jin , Koh Il-Hyun , Chung Kwangho , Lee Yong-Jae , Kim Hyoung-Sik 
Published: April 2020

Background: Osteoarthritis (OA) is a multifactorial disease involving inflammatory processes. Platelets play important roles in both hemostasis and the inflammatory response; however, the relationship between platelet count and OA is unclear. Our aim was to evaluate the association between platelet count and knee and hip OA in Korean women. Methods: In this cross-sectional designed study, we included a total of 6011 women aged ⩾50 years from the 2010–2013 Korea National Health and Nutrition Examination Survey. Knee and hip OA were defined as Kellgren–Lawrence grade ⩾2 and presence of knee or hip pain, respectively. Platelet counts were divided into quartiles as follows: Q1, 150–212 (103/µl); Q2, 213–246 (103/µl); Q3, 247–283 (103/µl); and Q4, 284–450 (103/µl). Multiple logistic-regression analysis was conducted to calculate odds ratios and 95% confidence intervals. Receiver operating characteristic analysis was performed to determine the optimal platelet count cut-off with which to discriminate participants with knee and/hip OA versus those without OA. Results: Of the 6011 participants, 1141 (18.1%) had knee or hip OA. The mean age of participants without OA was 60.6 years, and that of participants with OA was 68.0 years. Compared with the lowest quartile, odds ratios (95% confidence intervals) for OA were 1.08 (0.84–1.39) for Q2, 0.94 (0.73–1.23) for Q3, and 1.35 (1.08–1.69) for Q4 after adjusting for confounders. The prevalence of OA was significantly higher with platelet counts ⩾288 × 103/µl, compared with platelet counts <288 × 103/µl. Conclusion: High platelet counts within the normal range are significantly associated with knee and hip OA.
Achievement of European guideline-recommended lipid levels post-percutaneous coronary intervention: A population-level observational cohort study
Authors: Harris Daniel E , Lacey Arron , Akbari Ashley , Torabi Fatemeh , Smith Dave , Jenkins Geraint , Obaid Daniel , Chase Alex , Gravenor Mike , Halcox Julian 
Published: April 2020

AbstractAimsEuropean Society of Cardiology/European Atherosclerosis Society 2019 guidelines recommend more aggressive lipid targets in high- and very high-risk patients and the addition of adjuvant treatments to statins in uncontrolled patients. We aimed to assess (a) achievement of prior and new European Society of Cardiology/European Atherosclerosis Society lipid targets and (b) lipid-lowering therapy prescribing in a nationwide cohort of very high-risk patients.MethodsWe conducted a retrospective observational population study using linked health data in patients undergoing percutaneous coronary intervention (2012–2017). Follow-up was for one-year post-discharge.ResultsAltogether, 10,071 patients had a documented LDL-C level, of whom 48% had low-density lipoprotein cholesterol (LDL-C)&lt;1.8 mmol/l (2016 target) and (23%) &lt;1.4 mmol/l (2019 target). Five thousand three hundred and forty patients had non-high-density lipoprotein cholesterol (non-HDL-C) documented with 57% &lt;2.6 mmol/l (2016) and 37% &lt;2.2 mmol/l (2019). In patients with recurrent vascular events, fewer than 6% of the patients achieved the 2019 LDL-C target of &lt;1.0 mmol/l. A total of 10,592 patients had triglyceride (TG) levels documented, of whom 14% were ≥2.3 mmol/l and 41% ≥1.5 mmol/l (2019). High-intensity statins were prescribed in 56.4% of the cohort, only 3% were prescribed ezetimibe, fibrates or prescription-grade N-3 fatty acids. Prescribing of these agents was lower amongst patients above target LDL-C, non-HDL-C and triglyceride levels. Females were more likely to have LDL-C, non-HDL-C and triglyceride levels above target.ConclusionThere was a low rate of achievement of the new European Society of Cardiology/European Atherosclerosis Society lipid targets in this large post-percutaneous coronary intervention population and relatively low rates of intensive lipid-lowering therapy prescribing in those with uncontrolled lipids. There is considerable potential to optimise lipid-lowering therapy further through statin intensification and appropriate use of novel lipid-lowering therapy, especially in women.
Association between ideal cardiovascular health and risk of sudden cardiac death and all-cause mortality among middle-aged men in Finland
Authors: M Isiozor Nzechukwu , Kunutsor Setor K , Voutilainen Ari , Kurl Sudhir , Kauhanen Jussi , A Laukkanen Jari 
Published: April 2020

Abstract

Background
Strong associations have been demonstrated between the American Heart Association’s cardiovascular health (CVH) metrics and various cardiovascular outcomes, but the association with sudden cardiac death (SCD) is uncertain. We examined the associations between these CVH metrics and the risks of SCD and all-cause mortality among men in Finland.

Methods and results
We used the prospective population-based Kuopio Ischaemic Heart Disease cohort study, which consists of men between 42 and 60 years of age at baseline. CVH metrics were computed for 2577 men with CVH scores at baseline ranging from 0 to 7, categorized into CVH scores of 0–2 (poor), 3–4 (intermediate) and 5–7 (ideal). Multivariate Cox regression models were used to estimate the hazards ratios (HRs) and 95% confidence intervals (CIs) of ideal CVH metrics for SCD and all-cause mortality. During a median follow-up period of 25.8 years, 280 SCDs and 1289 all-cause mortality events were recorded. The risks of SCD and all-cause mortality decreased continuously with increasing number of CVH metrics across the range 2–7 (p value for non-linearity for all &lt;0.05). In multivariable analyses, men with an ideal CVH score had an 85% reduced risk of SCD compared with men with a poor CVH score (HR 0.15; 95% CI 0.05–0.48; p = 0.001). For all-cause mortality, there was a 67% lower risk among men with an ideal CVH score compared with those with a poor CVH score (HR 0.33; 95% CI 0.23–0.49; p &lt;0.001).

Conclusions
Ideal CVH metrics were strongly and linearly associated with decreased risks of SCD and all-cause mortality among middle-aged men in Finland.
Falgarite, K4(VO)3(SO4)5, a new mineral from sublimates of a natural underground coal fire at the tract of Kukhi-Malik, Fan-Yagnob coal deposit, Tajikistan
Authors: Pautov Leonid A. , Mirakov Mirak A. , Siidra Oleg I. , Faiziev Abdulkhak R. , Nazarchuk Еvgeny V. , Karpenko Vladimir Yu. , Makhmadsharif Saimudasir 
Published: April 2020

AbstractA new mineral falgarite, K4(V+4O)3(SO4)5 was discovered at the tract of Kukhi-Malik, Fan-Yagnob coal deposit, ca. 75 km N of Dushanbe, Tajikistan. The new mineral is named after the Falgar, an ancient Sogdian name for an area around the Zeravshan riverhead. Falgarite is a fumarolic mineral formed directly from a gas emitted by a natural underground coal fire. Associated minerals are anhydrite, baryte, molybdite, an unidentified Tl-vanadyl sulfate, K–Mg sulfate and an anhydrous Mg-sulfate. Falgarite forms small isometric or pseudo-octahedral individual crystals (10–60 μm) of turquoise colour and spherical aggregates up to 0.5 mm in diameter. Mohs hardness is ~ 2.5, Dmeas = 2.87(2) and Dcalc = 2.89 g/cm3. Refractive indices are: α = 1.588(3), β(calc.) = 1.600(3) and γ = 1.609(2) (590 nm). In transmitted light falgarite is transparent green with a weak pleochroism. The mineral is non-soluble in H2O and 5% HNO3 at room temperature. Infrared spectra support the absence of H2O and OH–. The chemical composition determined by electron-microprobe analysis is (wt.%): Na2O 0.55, K2O 20.76, Tl2O 1.83, VO2 29.38 and SO3 46.78, total 99.29. The empirical formula (based on 23 O apfu) is: (K3.76Na0.15Tl0.07)Σ3.98V3.02S4.99O23.0. The strongest lines of the powder X-ray diffraction pattern are [d,Å(I,%)(hkl)]: 3.20(70)(202); 3.17(80)024; 3.14(70)$\bar{2}$04; 3.01(50)$\bar{1}$51; and 2.88(100)151. Falgarite is monoclinic, P21/n, a = 8.7209(5), b = 16.1777(6), c = 14.4614(7) Å, β = 106.744(5)°, V = 1953.77(17) Å3, Z = 4 and R1 = 0.05. VO6 octahedra and SO4 tetrahedra link together by sharing corners thus forming a [(VO)3(SO4)5]4– framework. K+, Na+ and Tl+ cations are located in the channels of the framework. The synthetic K4(VO)3(SO4)5 analogue is known.
Facilitating resolution of life-threatening acute GVHD with human chorionic gonadotropin and epidermal growth factor
Authors: Holtan Shernan G. , Hoeschen Andrea L. , Cao Qing , Arora Mukta , Bachanova Veronika , Brunstein Claudio G. , Miller Jeffrey S. , Rashidi Armin , Slungaard Arne , Ustun Celalettin , Vercellotti Gregory M. , Warlick Erica D. , Betts Brian C. , El Jurdi Najla , He Fiona , Chen Chi , Gandhi Isha , Wagner John E. , Blazar Bruce R. , Jacobson Pamala Ann , Shabaneh Ashraf , Wang Jinhua , Panoskaltsis-Mortari Angela , MacMillan Margaret L. , Weisdorf Daniel J. 
Published: April 2020

Abstract
Acute graft-versus-host disease (aGVHD) is a potentially fatal complication of allogeneic hematopoietic cell transplantation that fails to improve with intense immunosuppression in some patients. We hypothesized that urinary-derived human chorionic gonadotropin (uhCG) could help facilitate resolution of life-threatening aGVHD when added as supportive care via 2 potential mechanisms: immunomodulation (akin to its role in pregnancy) and supplementation of epidermal growth factor (EGF; to aid in epithelial repair). In a phase 1 study, 26 participants received subcutaneous injections of uhCG in addition to standard immunosuppression (13 receiving initial therapy for high-risk aGVHD [according to the Minnesota criteria] and 13 receiving second-line therapy). Participants underwent serial blood testing for biomarkers of hormone response, immune modulation, and aGVHD activity on study. uhCG was well tolerated, with no dose-limiting toxicities. Sixty-two percent of patients in the high-risk cohort and 54% of patients in the second-line cohort had a complete response at study day 28. Plasma EGF was elevated sixfold (from 4 to 24 pg/mL; P = .02) at 6 hours postdose in the high-risk cohort, in contrast to no peak in plasma EGF in the more severe second-line cohort. After 1 week of uhCG, patients reported a twofold increase in the regulatory T cell to conventional T-cell ratio, suggesting immune modulation despite high-dose steroids. Responding patients reported significantly lower plasma amphiregulin and higher plasma butyrate levels at study completion, suggesting improvement in mucosal damage over time. uhCG is a novel, safe, supportive therapy, proceeding to phase 2 testing at 2000 units/m2 in high-risk aGVHD. This study was registered at www.clinicaltrials.gov as #NCT02525029.
Germline heterozygous mutations in Nxf1 perturb RNA metabolism and trigger thrombocytopenia and lymphopenia in mice
Authors: Chappaz Stéphane , Law Charity W. , Dowling Mark R. , Carey Kirstyn T. , Lane Rachael M. , Ngo Linh H. , Wickramasinghe Vihandha O. , Smyth Gordon K. , Ritchie Matthew E. , Kile Benjamin T. 
Published: April 2020

AbstractIn eukaryotic cells, messenger RNA (mRNA) molecules are exported from the nucleus to the cytoplasm, where they are translated. The highly conserved protein nuclear RNA export factor1 (Nxf1) is an important mediator of this process. Although studies in yeast and in human cell lines have shed light on the biochemical mechanisms of Nxf1 function, its contribution to mammalian physiology is less clear. Several groups have identified recurrent NXF1 mutations in chronic lymphocytic leukemia (CLL), placing it alongside several RNA-metabolism factors (including SF3B1, XPO, RPS15) whose dysregulation is thought to contribute to CLL pathogenesis. We report here an allelic series of germline point mutations in murine Nxf1. Mice heterozygous for these loss-of-function Nxf1 mutations exhibit thrombocytopenia and lymphopenia, together with milder hematological defects. This is primarily caused by cell-intrinsic defects in the survival of platelets and peripheral lymphocytes, which are sensitized to intrinsic apoptosis. In contrast, Nxf1 mutations have almost no effect on red blood cell homeostasis. Comparative transcriptome analysis of platelets, lymphocytes, and erythrocytes from Nxf1-mutant mice shows that, in response to impaired Nxf1 function, the cytoplasmic representation of transcripts encoding regulators of RNA metabolism is altered in a unique, lineage-specific way. Thus, blood cell lineages exhibit differential requirements for Nxf1-mediated global mRNA export.
Research and Development of Electro-hydraulic Control Valves Oriented to Industry 4.0: A Review
Authors: Xu Bing , Shen Jun , Liu Shihao , Su Qi , Zhang Junhui 
Published: April 2020

AbstractElectro-hydraulic control valves are key hydraulic components for industrial applications and aerospace, which controls electro-hydraulic motion. With the development of automation, digital technology, and communication technology, electro-hydraulic control valves are becoming more digital, integrated, and intelligent in order to meet the requirements of Industry 4.0. This paper reviews the state of the art development for electro-hydraulic control valves and their related technologies. This review paper considers three aspects of state acquisition through sensors or indirect acquisition technologies, control strategies along with digital controllers and novel valves, and online maintenance through data interaction and fault diagnosis. The main features and development trends of electro-hydraulic control valves oriented to Industry 4.0 are discussed.