bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic brain-to-brain concordance and behavioral mirroring as a mechanism of the patient-clinician interaction
Authors: Ellingsen Dan-Mikael , Isenburg Kylie , Jung Changjin , Lee Jeungchan , Gerber Jessica , Mawla Ishtiaq , Sclocco Roberta , Jensen Karin B , Edwards Robert Randolph , Kelley John M. , Kirsch Irving , Kaptchuk Ted J. , Napadow Vitaly 
Published: August 2020

AbstractThe patient-clinician interaction can powerfully shape treatment outcomes such as pain, but is often considered an intangible “art-of-medicine”, and has largely eluded scientific inquiry. Although brain correlates of social processes such as empathy and theory-of-mind have been studied using single-subject designs, the specific behavioral and neural mechanisms underpinning the patient-clinician interaction are unknown. Using a two-person interactive design, we simultaneously recorded functional MRI (i.e. hyperscanning) in patient-clinician dyads, who interacted via live video while clinicians treated evoked pain in chronic pain patients. Our results show that patient analgesia is mediated by patient-clinician nonverbal behavioral mirroring and brain-to-brain concordance in circuitry implicated in theory-of-mind and social mirroring. Dyad-based analyses showed extensive dynamic coupling of these brain nodes with the partners’ brain activity, yet only in dyads where clinical rapport had been established prior to the interaction. These findings point to a putatively key brain-behavioral mechanism for therapeutic alliance and psychosocial analgesia.
Does plant root architecture respond to potassium nutrition under water stress? A case from rice seedling root responses
Authors: Patel Dipika S. , Kirti Bardhan , Patel Dhiraji P , Vipulkumar Parekh , Suchismita Jena , Narwade Ajay V. , Chhatrola Harshadkumar N 
Published: August 2020

ABSTRACTThe root is the sensing organ for potassium (K) and water availability. We evaluated whether K availability influences root architecture and contributes to drought tolerance under moisture stress. Rice seedling growth was severely affected by low K availability under water stress, and the substantial reductions in root projected area, maximum width, and width to depth ratio were observed. High K availability helps maintain root top and bottom angles and reduces root steepness under mild water stress, but over K nutrition does not ensure higher seedling growth. Under severe water stress, the steepness was more regulated by water than K availability.
Enhancing employee advocacy on social media: the value of internal relationship management approach
Authors: Lee Yeunjae , Kim Katie Haejung 
Published: August 2020

PurposeTo advance the theoretical understanding of employees' advocacy on social media, this study aims to propose and test an integrative model that incorporates individual and organizational antecedents. Drawing from the relationship management theory in public relations and online behavior literature, the model specifically examines the collective impacts of the social media-related behavioral motivations of individuals and the quality of employee–organization relationship (EOR) on their positive information-sharing intentions about their company on personal social media.Design/methodology/approachAn online survey was conducted with 419 full-time employees in the USA who use social media.FindingsThe results of an online survey with full-time employees in the USA showed that the EOR influenced by symmetrical internal communication significantly increases employees' advocacy intentions and social media-related motivations. Considerable and distinct effects of individuals' positive behavioral motivations on social media (i.e. self-enhancement, altruism, enjoyment) on advocacy intentions are also found.Originality/valueThis study is among the first attempts to test the value of strategic internal communication and relationship management approach in enhancing employee advocacy on the digital environment, social media and their motives of using such channel for benefiting their company.
Current trends analysis and prioritization of success factors: a systematic literature review of ICT projects
Authors: Ayat Muhammad , Imran Muhammad , Ullah Azmat , Kang Chang Wook 
Published: August 2020

PurposeThe purpose of this study is to investigate the current literature that has explored project success in the information and communication technology (ICT) sector.Design/methodology/approachThe literature search was carried out for related articles in three databases: the Web of Science, Scopus and Ebscohost. Using a systematic literature review (SLR) methodology, 75 related articles were sorted out. Furthermore, the methods of frequency and content analysis were used to identify, categorize and arrange critical success factors (CSF) of ICT projects based on their importance, interrelation and cultural regions.FindingsThe findings in this study revealed that interest in researching success in ICT projects has increased significantly during the last five years. Through reviewing the selected articles, 25 CSF were identified. User participation, stakeholder relationship, project manager emotional intelligence, communication skills, and leadership skills, and top management support in the project emerged as the most important factors for ICT projects. Furthermore, we found that each regional group gives different level of importance to different CSF.Practical implicationsThis study gives the opportunity to practitioners to control the highest value CSF to increase the success rate of ICT projects carried out in different cultural regions.Originality/valueAs the first study of its type, CSF were divided for different cultural regional groups. This paper further explained that certain CSF have different levels of importance in different culture regions. This study suggests that regional culture needs consideration during the evaluation of CSF.
Government transition in the time of the COVID-19 crisis: Slovak case
Authors: Nemec Juraj 
Published: August 2020

PurposeMost media evaluate Slovakia as the most successful European country in the fight against the spread of coronavirus disease 2019 (COVID-19). Such excellent results have been achieved in a really specific period – the change of the government overlapped the initial days of the outbreak of the pandemic in the country. The goal of this viewpoint paper is to investigate how individual public leaders (Prime Ministers) shaped the governance response, how these key political leaders have helped to make the transition to a new government so seamless in times of crisis.Design/methodology/approachQualitative approach is used to map the situation and to show how key political leaders shaped the governance response to the crisis. The official government COVID-19 web page and core national media were investigated to collect the necessary information for our research.FindingsThe most positive finding of this article is the fact that the departing Prime Minister Pellegrini did not decide to wait till the end of office in a passive or moderate way, but managed during last days of office of “his” government to realize a set of really comprehensive measures to prevent the spread of COVID-19 in Slovakia. Politics has been set a bit aside; coalition and opposition parties prioritized the need to fight COVID-19 instead of the need for permanent political fights.Originality/valueThe article introduces the example of the political “takeover” during the crisis, which has been realized in such positive ways, especially thanks to the fact that Pellegrini behaved as a real national leader just a few days before leaving office.
Robot posture generation method for laser melting deposition
Authors: Zheng Huadong , Wang Caidong , Fei Zhigen , Chen Lumin , Cheng Yan 
Published: August 2020

Purpose
This paper aims to provide a posture generation method of robot deposition paths based on intersection topology, which is helpful to contribute to improving the flexibility and deposition capability of the deposition system.

Design/methodology/approach
Via the geometry information and normal vector information of the stereolithography (STL) model, the intersecting edge information is generated and the topological relationship of the model is established. Through the removal of redundant points for the STL model and the sort of robot path points, the position information of robot path points is obtained. According to the geometric relationship between the normal vector information of the STL model and the robot deposition path points, combining with the robot posture representation method of roll-pitch-yaw angles, the posture information of path points is achieved. Then, the generation from CAD model of parts to robot paths for laser melting is realized, and the experimental verification is carried out.

Findings
For simple parts, the laser melting process can be completed without the posture information of deposition paths. However, in the melting process of a turbine blade, there are some accumulated burls on the sidewall. The posture generation method of robot deposition paths based on the intersection topology can solve this problem. The light spot of deposition points irradiates on the surface of the forming part, and the forming process can proceed smoothly.

Practical implications
As a motion platform in laser melting deposition (LMD), the application of the multi-joint robot can improve the flexibility and deposition capability of the deposition system, as well as promote the LMD application for individuation manufacturing, parts repair and green remanufacturing.

Originality/value
The posture is essential for robot deposition paths. This paper first proposes a posture generation method of deposition paths for LMD to improve the flexibility and deposition capability of LMD systems.
Factors affecting pre-visit destination image: application on the Grand Egyptian Museum (GEM)
Authors: El Sheikh Samia Adly Hanna 
Published: August 2020

PurposeThe purpose of this study is to investigate through an empirical research the factors that would attract visitors to heritage and cultural sites as museums applied on the Grand Egyptian Museum (GEM). The paper aims to study the impact of the proposed attraction features learning/knowledge, museum facilities, fun/entertainment and socializing and accessibility/location on pre-visit destination image.Design/methodology/approachThe author started by a thorough literature review to arrive to the suggested conceptual model, which is tested by adopting a quantitative approach where data were collected using a self-administered questionnaire from a convenient sample of 300 respondents with 90% response rate and used partial least squares – structure equation modelling using Smart PLS v.3.2.8.FindingsThe results show that three of the tested factors were accepted and one was rejected.Practical implicationsManagement of GEM, which will be one of the biggest museums world-wide, can make use of the empirical results of this research to enhance their understanding of the factors that impact pre-visit destination image, and thus, most attract visitors to justify the budget set in this huge project and achieve highest visitation and revenueOriginality/valueThis research deals with a new museum that has not opened its doors yet and will start functioning in late 2020, and thus, the pre-visit image of the museum is not based on previous experience of visitors but rather on secondary sources as messages sent to visitors based on attraction features, while most previous studies dealt with post-visit image of museums
Employees’ perceptions of organizational learning: the role of knowledge and trust
Authors: Kim Eunjee , Park Sunyoung 
Published: August 2020

Purpose
This paper aims to investigate the roles of employees’ perceived knowledge sharing and trust on organizational learning.

Design/methodology/approach
The authors examined the proposed hypotheses by using survey data from 228 responses collected from an IT services company.

Findings
The authors found that a knowledge sharing culture was positively related to interpersonal trust, knowledge sharing behavior and organizational learning. Employees’ perceived trust among people had a positive effect on knowledge sharing behavior and organizational learning. Knowledge sharing behavior was also positively related to organizational learning. In addition, interpersonal trust and knowledge sharing behavior played mediating roles in linking knowledge sharing culture and organizational learning.

Originality/value
This study provides empirical support for the mediating role of interpersonal trust and knowledge sharing behavior on the link between knowledge sharing culture and organizational learning.
Exon splicing analysis of intronic variants in multigene cancer panel testing for hereditary breast/ovarian cancer
Authors: Ryu Jin‐Sun , Lee Hye‐Young , Cho Eun Hae , Yoon Kyong‐Ah , Kim Min‐Kyeong , Joo Jungnam , Lee Eun‐Sook , Kang Han‐Sung , Lee Seeyoun , Lee Dong Ock , Lim Myong Cheol , Kong Sun‐Young 
Published: August 2020

AbstractThe use of multigene panel testing for patients with a predisposition to breast/ovarian cancer is increasing as the identification of variants is useful for diagnosis and disease management. We identified pathogenic and likely pathogenic (P/LP) variants of high‐and moderate‐risk genes using a 23‐gene germline cancer panel in 518 patients with hereditary breast and ovarian cancers (HBOC). The frequency of P/LP variants was 12.4% (64/518) for high‐ and moderate‐penetrant genes, namely, BRCA2 (5.6%), BRCA1 (3.3%), CHEK2 (1.2%), MUTYH (0.8%), PALB2 (0.8%), MLH1 (0.4%), ATM (0.4%), BRIP1 (0.4%), TP53 (0.2%), and PMS2 (0.2%). Five patients possessed two P/LP variants in BRCA1/2 and other genes. We also compared the results from in silico splicing predictive tools and exon splicing patterns from patient samples by analyzing RT‐PCR product sequences in six P/LP intronic variants and two intronic variants of unknown significance (VUS). Altered transcriptional fragments were detected for P/LP intronic variants in BRCA1, BRIP1, CHEK2, PARB2, and PMS2. Notably, we identified an in‐frame deletion of the BRCA1 C‐terminal (BRCT) domain by exon skipping in BRCA1 c.5152+6T>C—as known VUS—indicating a risk for HBOC. Thus, exon splicing analysis can improve the identification of veiled intronic variants that would aid decision making and determination of hereditary cancer risk.
Impact of HEC72702 chirality on the selective inhibition of hepatitis B virus capsid dimer: A dynamics–structure–energetics perspective
Authors: Farrokhzadeh Abdolkarim , Badichi Akher Farideh , Olotu Fisayo A. , Van Heerden Fanie R. 
Published: August 2020

AbstractChirality in drug design has been attracting wide interests and attention over the years based on its innate potentials of enhancing the selectivity and prowess of therapeutic molecules. This approach was fundamental to the recent design of two inhibitors, where (R,R)‐HEC72702 exhibited higher potency inhibition against hepatitis B virus capsid (HBVC) than (R,S)‐HEC72702. Nevertheless, the detailed molecular mechanism has remained unresolved. Here, we apply multiple computational approaches to explore, validate, and differentiate the binding modes of (R,R) and (R,S)‐HEC72702 and to explain the systematic roles mediated by chirality on the distinctive inhibition of HBVC dimer (HBVCd). Our findings revealed that chirality change from R,S to R,R engenders variations in the position of the propanoic acid group of HEC72702 toward the α5′ and C‐TER′ region of HBVCd chain B which could explain the higher inhibitory affinity of (R,R)‐HEC72702. Estimated binding free energies revealed a good correlation with bioactivity data. Moreover, analysis of energy decomposition revealed the prominent effects of van der Waals interactions in the binding process of both compounds to HBVCd. Furthermore, hierarchical clustering of residue‐based energetic contributions suggested two hot‐spot residues W125´ and F156´ play crucial roles in the systematic motions of the propanoic acid group toward chain B.
2017 KLEIN LECTURE: THE SCIENCE OF USING SCIENCE: TOWARD AN UNDERSTANDING OF THE THREATS TO SCALABILITY
Authors: Al‐Ubaydli Omar , List John A. , Suskind Dana 
Published: August 2020

AbstractPolicymakers are increasingly facing the challenge of scaling empirical insights. This study provides a theoretical lens into the science of how to use science. Through a simple model, we highlight three elements of the scale‐up problem: (1) when does evidence become actionable; (2) properties of the population; and (3) properties of the situation. Until these three areas are fully understood, the threats to scalability will render any scaling exercise as particularly vulnerable. Accordingly, our work represents a call for more policy‐based evidence, whereby the nature and extent of the various threats to scalability are explored in the original research program.
Complex roles of Rabs and SNAREs in the secretory pathway and plant development: a never‐ending story
Authors: MARTINIÈRE A. , MOREAU P. 
Published: August 2020

SummaryMembrane trafficking is critical for cell compartmentation which allows the maintenance of specialised environments required for specific cellular activities. To achieve this goal, cells need to tightly regulate vesicle transport between donor and acceptor compartments. Several different protein families are involved: among them the SNAREs (65 genes) and the small GTPases Rabs (57 genes) show the highest number of isoforms and will be in the spotlight. We will focus on the roles of these proteins in the ER–Golgi–plasma membrane pathway to illustrate how Rabs and SNAREs are involved to achieve specific set of functions.Lay DescriptionProtein and lipid transport between the different compartments inside cells are critical for many physiological functions of organisms. To achieve this goal, cells have developed several vesicular transport systems between these compartments. Numerous different protein families are involved in these processes among which two protein families are the focus of the review in plant cells: the SNAREs and the small GTPases Rabs. These proteins are essentially controlling the different steps of the transport processes to warrant that proteins and lipids will reach the right compartments. The SNAREs are encoded by 65 genes meaning that plant cells synthesise 65 different SNARE proteins, and the small GTPases Rabs are encoded by 57 genes meaning that plant cells synthesise 57 different GTPases Rabs proteins. This high number of proteins illustrates the complexity of the vesicular transport systems existing between plant cell compartments. The review discusses the different roles of these proteins in these processes and particularly in the functioning of the secretory pathway which contributes to transport proteins and lipids to the cell surface. The review describes how the Rabs and SNAREs proteins are involved to achieve their respective set of functions in the different transport pathways of plant cells, and illustrates the tremendous complexity of these mechanisms.
Primary vulvar Ewing sarcoma/peripheral primitive neuroectodermal tumor with pelvic lymph nodes metastasis: A case report and review of literature
Authors: El Housheimi Alaa , Khalil Ali , Khalifeh Dalia , Berjawi Ghina , Seoud Muhieddine , Tabbarah Abir , Khaled Chirine , Mahfouz Rami , Abdallah Reem 
Published: August 2020

AbstractEwing sarcoma (ES) and peripheral primitive neuroectodermal tumors (pPNET) are soft tissue tumors that generally affect the bones. Extraosseous ES/pPNET has been rarely reported. Our patient presented with a 6 × 4 cm right subcutaneous solid vulvar lesion causing pain and discomfort. Pathology and immunohistochemistry staining showed strong positivity for CD99 and vimentin, favoring the diagnosis of ES/pPNET. Magnetic resonance imaging showed a 6‐cm lesion in the right vulvar region with enlarged bilateral inguinal and right iliac lymph nodes. Fluorescence in situ hybridization test for translocation t(11;22)(q24;q12) was positive, confirming the diagnosis. The patient received three cycles of neoadjuvant chemotherapy with vincristine, adriamycin, cyclophosphamide alternating with ifosfamide and etoposide with complete response. The patient underwent vulvar radical local excision. Residual tumor measured 1.6 cm with free margins. She received four additional cycles of adjuvant chemotherapy and 30 sessions radiotherapy. She is currently disease free after 37 months. No ES/pPNET cases with pelvic lymph nodes metastasis were ever reported.
Immunomodulatory and antitumour bioactive labdane diterpenoids from Leonurus japonicus
Authors: Yue Grace Gar-Lee , Liang Xin-Xin , Li Xiao-Li , Lee Julia Kin-Ming , Gao Si , Kwok Hin-Fai , Lau Clara Bik-San , Xiao Wei-Lie 
Published: August 2020

Abstract

Objectives
Two labdane diterpenoids, leojapone B and heteronone B, were isolated from Leonurus japonicus Houtt., and their biological activity were evaluated in this study.

Methods
Human and mouse cancer cells, human peripheral blood mononuclear cells (PBMCs) and mouse macrophages (RAW264.7 cells) were used to evaluate the activity of leojapone B and heteronone B, while the in vivo effects of leojapone B were further examined in Lewis Lung Cancer tumour-bearing mice.

Key findings
In vitro studies showed that leojapone B selectively inhibited the proliferation of lung cancer cells, and both leojapone B and heteronone B inhibited the production of pro-inflammatory cytokines in activated PBMCs. In tumour-bearing mice model, lung tumours were reduced in size in mice treated with intraperitoneal injections of leojapone B at 20 and 30 mg/kg for 14 days. The population ratio of CD4+/CD8+ T cells in mouse spleens was found to be increased, while regulatory T cells were decreased after leojapone B treatment.

Conclusions
The inhibitory effects of leojapone B in mouse lung tumours were demonstrated for the first time in this study. The immunomodulatory activity of heteronone B were also demonstrated. Our findings indicated that both leojapone B and heteronone B may act as active components in L. japonicus.
Efficacy of gastric electrical stimulation in intractable nausea and vomiting at 10 years: A retrospective analysis of prospectively collected data
Authors: Hedjoudje Abdellah , Huet Emmanuel , Leroi Anne‐marie , Desprez Charlotte , Melchior Chloé , Gourcerol Guillaume 
Published: August 2020

AbstractBackgroundGastric electrical simulation has been shown to relieve nausea and vomiting in medically refractory patients. Efficacy of gastric electrical stimulation has been reported mostly in short‐term studies, but none has evaluated its efficacy beyond 10 years after implantation.MethodsPatients implanted at our center for medically refractory severe and chronic nausea and/or vomiting were evaluated before and over 10 years after implantation using symptomatic scale and quality of life (GIQLI) score. Improvement was defined as a reduction of more than 50% in vomiting frequency.Key ResultsA total of 50 patients were implanted from January 1998 to December 2009. Among them, 7 were explanted due to a lack of efficacy and/or side effects, 2 died, and 4 were lost to follow‐up. Mean follow‐up was 10.5 ± 3.7 years. In intention‐to‐treat analysis, 27/50 (54%) patients reported an improvement. Beyond 10 years, an improvement in early satiety (3.05 vs 1.76, <0.001), bloating (2.51 vs 1.70, P = .012), nausea (2.46 vs 1.35, P = .001), and vomiting (3.35 vs 1.49 P < .001) scores were observed. Quality of life improved over 10 years (GIQLI score: 69.7 vs. 86.4, P = .005) and body mass index (BMI: 23.4 vs. 26.2 kg/m2; P = .048).Conclusions and InferencesGastric electrical simulation is effective in the long‐term in patients with medically refractory nausea and vomiting, with an efficacy of 54% at 10 years on an intention‐to‐treat analysis. Other long‐term observational studies are warranted to confirm these results.