bluuebunny/crossref_metadata_2025_split huggingface dataset:
The correlation between neck circumference and risk factors in patients with hypertension
Authors: Zhang Yudan , Wu Haixia , Xu Yilian , Qin Huang , Lan Cuizhen , Wang Wenzhen 
Published: November 2020

Abstract
It is necessary to identify the relationship between neck circumference and cardiovascular risk factors in patients with hypertension.
Patients with hypertension treated in our hospital were included. The height, weight, neck circumference, waist circumference, fasting blood glucose, 2 h blood glucose (2hPPG), density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and glycated hemoglobin (HbA1c) were analyzed and compared.
A total of 2860 patients with hypertension were included. There were significant differences between male and female patients in the neck circumference, waist circumference, fasting blood glucose, Total cholesterol, triacylglycerol, HDL-C, LDL-C, diabetes, metabolic syndrome, dyslipidemia, drinking and smoking (all P < .05); the neck circumference was positively correlated with waist circumference, body mass index (BMI), fasting blood glucose, 2hPPG, HbA1c, triacylglycerol and LDL-C (all P < .05), and negatively correlated with HDL-C (P = .014); as the neck circumference increases, the risk of hypertension, diabetes, metabolic syndrome, abdominal obesity, and dyslipidemia increases accordingly (all P < .05); the area under curve (AUC) was 0.827 and 0.812, and the neck circumference of 37.8 and 33.9 cm was the best cut-off point for male and female patients, respectively.
Neck circumference is closely related to cardiovascular risk factors in patients with hypertension, which should be promoted in the screening of cardiovascular diseases.
Comorbid irritable bowel syndrome symptoms and headache have greater association with anxiety than depression
Authors: Kawashima Kousaku , Fukuba Nobuhiko , Uemura Yusuke , Ota Kuniko , Kazumori Hideaki , Sonoyama Hiroki , Oka Akihiko , Tada Yasumasa , Mishima Yoshiyuki , Oshima Naoki , Yuki Takafumi , Katsube Tomoko , Kinoshita Yoshikazu , Ishihara Shunji 
Published: November 2020

Abstract
High rates of co-existing irritable bowel syndrome (IBS) and headache have been reported in western countries. We investigated that comorbidity in individuals in Japan, along with anxiety and depression in subjects with and without IBS symptoms and/or headache.
This cross-sectional study was performed from April 2012 to January 2013 at the Matsue Seikyo General Hospital Health Check Center. Questionnaires concerning symptoms related to IBS (Rome III) and headache, as well as anxiety/depression score were sent to individuals scheduled to undergo an annual health check-up, then returned during the visit and analyzed in a blinded manner.
A total of 2885 individuals returned completed questionnaires and were enrolled, of whom 218 (7.6%) met the IBS criteria. The rates of co-existing headache in subjects with and without IBS symptoms were 44.0% (96/218) and 22.9% (611/2667), respectively, indicating a significantly higher rate of co-existing headache in subjects with as compared to without IBS (odds ratio [OR] 2.65, P < .001). Furthermore, the percentage of subjects with anxiety along with comorbid IBS symptoms and headache was significantly greater as compared to those with IBS (OR 3.01, P = .001) or headache (OR 2.41, P < .001) alone. Unlike anxiety, the percentage of subjects with depression was not significantly different among the IBS/non-headache, non-IBS/headache, and IBS/headache groups.
Subjects with IBS symptoms had a higher rate of co-existing headache as compared to those without IBS. Furthermore, those with comorbid IBS symptoms and headache had a greater association with anxiety than with depression, as compared to those with only IBS or headache.
Isoniazid preventive therapy in HIV-infected pregnant and postpartum women in high prevalence of tuberculosis countries
Authors: Wang Xiaozhuan , Zhang Yun , Lin Xiaojuan , Fu Yu , Sun Qingmei , Li Jing , Liu Xiaoling , Bai Jing 
Published: November 2020

Abstract

Background:
Tuberculosis (TB) is the leading cause of health complications and death among human with immunodeficiency virus (HIV) infection. When TB develops during pregnancy or the early postpartum period, it is associated with negative maternal, pregnancy, and fetus and infant outcome, including premature birth, low birth weight, and congenital or neonatal TB infection or disease. The objective of this systematic review is to investigate the effective and safe of isoniazid for preventing TB for HIV-infected pregnant women in counties with high prevalence of TB.

Methods:
Pubmed, Embase, and Cochrane library will be searched to include randomized control trials which compared isoniazid preventive therapy with placebo for preventing TB in HIV-infected pregnant and postpartum women. RevMan version 5.3 will be used to perform all calculations related to the meta-analysis. Dichotomous data will be calculated in terms of a fixed or random effect model and expressed by the relative risk (RR) with 95% confidence interval (CI). The Cochrane collaboration's tool in the following aspects was used to assess the risk of bias (ROB) in included studies. The inconsistency index (I2) and Chi-squared will be applied for heterogeneity detection between clinical trials. A value of P < 0.05 will be considered statistically significant.

Results:
The main outcomes of pooled evidence synthesis will be presented including the incidence of TB and adverse events.

Conclusion:
This study will provide the evidence of whether isoniazid is an effective and safe intervention for preventing TB for HIV-infected pregnant women.

Registration number:
INPLASY202070011
Aberrant brain-expressed X-linked 4 (BEX4) expression is a novel prognostic biomarker in gastric cancer
Authors: Zhu Chenhong , Xiao Deshuang 
Published: November 2020

Abstract

Background:
This study aimed to investigate the expression level of X-linked 4 (BEX4) in patients with gastric cancer (GC) and to investigate the prognostic significance of BEX4.

Methods:
The mRNA expression of BEX4 was analyzed using the Cancer Genome Atlas (TCGA) datasets. The relationship between the expression of BEX4 and GC patient survival was assessed using a Kaplan-Meier plot and Log Rank test. Multivariate cox regression analysis was used to evaluate prognostic factor. The diagnostic value of BEX4 expression in GC tissue was determined through receiver operating characteristic (ROC) curve analysis. Gene set enrichment analysis (GSEA) was used to explore BEX-4 related signaling pathways in GC. Furthermore, the Human Protein Atlas (HPA) database and GSE62254 dataset were used for further validation.

Results:
BEX4 was expressed at lower level in GC tissues than normal gastric tissues. The lower expression of BEX4 was also validated at protein level in HPA database. The area under the ROC curve for BEX4 expression in normal gastric tissue and GC was 0.791, which presented modest diagnostic value. Kaplan-Meier survival analysis revealed that patients in low BEX4 expression group had a worse prognosis than those with high BEX4 expression (P = .009). Multivariate analysis showed that BEX4 is an independent risk factor for overall survival both in TCGA and GSE62254 (P = .0142, .013, respectively). GSEA identified that the expression of BEX4 was related to DNA replication, RNA polymerase, cell cycle, and P53 signaling pathway.

Conclusion:
BEX4 is expressed at low levels in GC. BEX4 expression independently predicted poor OS for GC. It is a promising independent molecular predictor for the diagnosis and prognosis of GC.
Topical clotrimazole cream for the treatment of tinea cruris
Authors: Zhao Dan , Chen Bing , Wang Ying-Ting , Jiao Chuan-Hua 
Published: November 2020

Abstract
This retrospective study assessed the efficacy and safety of 1% topical clotrimazole cream for the treatment of patients with tinea cruris (TC).
We included 86 patients with confirmed TC for the presence of fungal hyphae. Of those, 43 patients received 1% topical clotrimazole cream for a total of 4 consecutive weeks, and were assigned to an experimental group. The other 43 patients underwent 1% topical butenafine cream for a total of 2 consecutive weeks, and were allocated to a control group. The efficacy and safety were measured and analyzed after 4 weeks treatment.
After treatment, patients in both groups achieved better improvements in erythema (P < .01), scaling (P < .01), itching (P < .01), and KOH-negative results (P < .01), compared with those in patients before the treatment. However, there were not significant differences in erythema (P = .61), scaling (P = .57), itching (P = .47), and KOH-negative results (P = .67) between 2 groups. In addition, no treatment-related adverse events were recorded in both groups.
Both 1% topical clotrimazole and butenafine cream are found to be effective and safe for patients with TC. However, there is not significant difference in efficacy and safety between two groups.
Efficacy and safety of Brucea javanica oil emulsion for liver cancer
Authors: Luo Didi , Hou Daorui , Wen Tiancheng , Feng Meiling , Zhang Haiming 
Published: November 2020

AbstractBackground:Brucea javanicaoil emulsion (BJOE), extracted from the Chinese herbBruceae Fructus (Yadanzi), is a broad-spectrum anti-tumor drug and has been widely used for the treatment of liver cancer in China. The aim of this study is to systematically investigate the efficacy and safety of BJOE for the treatment of liver cancer.Methods:Seven electronic databases including the Cochrane Library, PubMed, Excerpt Medica Database, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, China Scientific Journal Database, and Wanfang Database will be systematically retrieved for data extraction from their inceptions to September 2020. Cochrane Risk of Bias tool will be used to assess the risk of bias of included studies. The RevMan 5.4 and Stata 16.0 software will be applied for statistical analyses. Statistical heterogeneity will be computed byI2tests. Sensitivity analysis will be conducted to evaluate the stability of the results. The publication bias will be evaluated by funnel plots and Egger test. The quality of evidence will be assessed by the GRADE system.Results:The results of our research will be published in a peer-reviewed journal or presenting the findings at a relevant conference.Conclusion:The conclusion of this study will provide helpful evidence of the effect and safety of BJOE for the treatment of liver cancer in clinical practice.OSF registration number:10.17605/OSF.IO/UC8XQ
Pregnancy outcome treated with stage-by-stage acupuncture and moxibustion therapy based on the chong channel being sea of blood theory in repeated IVF-ET failure patients
Authors: Xing Liwei , Xu Jinlong , Zhang Qiong , Li Li , Li Yunxiu , Zhuang Haina , Yuan Zhuojun , Zhao Rong , Ma Yanping 
Published: November 2020

Abstract

Introduction:
Acupuncture and moxibustion has become a commonly used adjuvant treatment method to improve the success rate of in vitro fertilization-embryo transfer (IVF-ET). However, There is still insufficient evidence that acupuncture treatment can improve the local microenvironment of endometrium, the endometrial receptivity, and the pregnancy outcome of patients, which is worthy of further study.

Method/Design:
To investigate the effect of Stage by Stage Acupuncture and Moxibustion Therapy on endometrial receptivity and Pregnancy Outcome based on the theory of “Chong channel being sea of blood,” we will conduct a multicenter randomized controlled trial. Inclusion criteria are as follows: infertile women under 45 years of age who received IVF-ET or Intracytoplasmic sperm injection cycles. The study will only be applied to women who have failed repeated implantation, that is, women who have failed 3 or more embryo transplants in the past (existing frozen embryos do not require the retrieval of eggs). Those who are not prepared to receive IVF-ET or are at risk of pregnancy, have a serious medical condition, or are egg donors will be excluded. Subjects will be randomly assigned to either the acupuncture group (IVF-ET plus stage-by-stage acupuncture and moxibustion therapy based on the “Chong channel being sea of blood” theory) or the control group (IVF-ET only). The trial required a total sample size of 246 women to compare endometrial receptivity between the 2 groups. The acupuncture group will receive acupuncture and moxibustion treatment 3 times a week starting from the third day of menstruation in the ovary stimulation cycle. One menstrual cycle was one course of treatment, and a total of 3 menstrual cycles were treated. The main outcome indicator was clinical pregnancy rate. Secondary outcome indicators were the three-dimensional volume blood flow parameters (vascularization index, flow index, and vascularization flow index) of the endometrium, endometrial thickness, endometrial volume, uterine artery PI, RI, and S/D during the “implantation window period” (20–24 days after menstruation in the ovary stimulation cycle).

Discussion:
This study will provide important evidence for the use of Stage by Stage Acupuncture and Moxibustion Therapy Based on the “Chong Channel Being Sea of Blood” Theory in IVF.

Trial registration:

http://www.chictr.org.cn/edit.aspx?pid=28811&htm=4 ID: ChiCTR1800017191 (07/17/2018).
Efficacy and safety of endovascular coiling vs surgical clipping for patients with ruptured carotid-ophthalmic aneurysm
Authors: Feng Guan-Jun , Gao Feng , Huang Xiao-Yuan , Hati Paer , Yang Xiao-Peng , Wu Hong-Xing 
Published: November 2020

Abstract

Background:
Carotid-ophthalmic aneurysms are relatively rare, and represent 1% of all intracranial aneurysms. Generally, endovascular coiling and surgical clipping are the 2 most commonly used methods to treat ruptured carotid-ophthalmic aneurysms, it provides the most favorable outcome for a patient. This study aims to assess the efficiency and safety of endovascular coiling vs surgical clipping for patients with a ruptured carotid-ophthalmic aneurysm.

Methods:
A comprehensive systematic literature review was done in PubMed, EMBASE, Cochrane Library, Web of Science, Scopus, China National Knowledge Infrastructure (CNKI), and WanFang databases. Only randomized trials that compared endovascular coiling with surgical clipping in patients with ruptured carotid-ophthalmic aneurysm was included. Data was extracted independently by 2 review authors. Moreover, the quality of study and bias risk was evaluated by utilizing an appropriate method. Triallists will be contacted to acquire missing information. The data is presented as risk ratio and mean difference, or standardized mean difference with 95% confidence intervals.

Results:
The results from the present research shall be published in a peer-reviewed journal.

Conclusion:
The present study summarizes the direct and in-direct evidence to judge the efficiency and safety of these 2 methodologies to treat ruptured carotid-ophthalmic aneurysms and attempt to find the most efficiency and safety therapeutical method.

Ethics and Dissemination:
The present study is a meta-analysis based on published evidence. As a result, ethics approval and patient consent are not needed.
There is no association between weekend admissions and delays in antibiotic administration for patients admitted to the emergency department with suspicion of sepsis
Authors: Fahel Bruno V. B. , Manciola Marina , Lima Gabriel , Barbosa Manoel H. , Starteri Chuva , Ramos João Gabriel Rosa , Caldas Juliana R. , Passos Rogério da Hora 
Published: November 2020

Abstract
Admission to the emergency department (ED) on weekends has been associated with an increase in mortality and poor outcomes, but the associated findings are not consistent. It has been hypothesized that this association may be due to lower adherence to standards of care.
This study was conducted to evaluate whether weekend admissions to the ED increases the time to antibiotic administration in septic patients.
A retrospective cohort study of adult patients who were included in the sepsis protocol at a tertiary ED between January 2015 and December 2017 was performed. The sepsis protocol was activated for all patients with suspected severe infection.
A total of 831 patients with a mean age of 59 ± 21 years were evaluated, of whom 217 (26.1%) were admitted on weekends. In addition, 391 (47.1%) patients were male, and 84 (10.1%) died in the hospital. Overall, the mean sequential organ failure assessment score was 2 ± 1.9, and the mean Charlson comorbidity index was 3.7 ± 3. The time to antibiotic administration was similar between patients admitted on weekends (36.29 ± 50 minutes CI 95%) and patients admitted on weekdays (44.44 ± 69 minutes CI 95%), P = .06; U = 60174.0. Additionally, mortality was similar in both groups of patients, with a 10.3% mortality rate on weekdays and a 9.8% mortality rate on weekends, P = 821.
In this cohort of patients with suspicion of sepsis in the ED, admission on weekends was not associated with increased delays in antibiotic therapy or higher mortality rates.
Imaging features of granular cell tumor in the breast
Authors: Zeng Qiao , Liu Lan , Wen Qingyi , Hu Liping , Zhong Linhua , Zhou Yongjie 
Published: November 2020

Abstract

Rationale:
Granular cell tumor of the breast (GCTB) is a benign rare tumor. There are limited reports on its imaging manifestations. GCTB is often misdiagnosed as breast cancer, which results in unnecessary radical mastectomy and excessive treatment. In this article, we have reported a case of a 56-year-old postmenopausal woman with GCTB and highlighted the imaging features to differentiate this rare tumor from breast cancer.

Patient concerns:
A 56-year-old postmenopausal patient had a chief complaint of a subcutaneous nodule in the upper outer quadrant of her right breast for 2 months. She underwent physical examination, color Doppler ultrasonography, mammography, magnetic resonance, and postoperative pathology.

Diagnoses:
The final diagnosis was GCTB. The tumor cells were intermingled with the fibrous stroma and normal breast parenchyma and showed positive immunoreaction to S-100, CD68, and neuron-specific enolase.

Interventions:
The patient underwent lumpectomy and sentinel lymph node biopsy.

Outcomes:
The patient recovered well after lumpectomy and had no complications during the 2-year follow-up.

Lessons:
There are some important imaging features of GCTB that can be used to distinguish it from breast carcinoma to reduce misdiagnosis.
Prevalence and the predictive performance of the dynamic CT-angiography spot sign in an observational cohort with intracerebral hemorrhage
Authors: Dowlatshahi Dar , Chung Hee Sahng , Reaume Michael , Hogan Matthew J. , Blacquiere Dylan , Stotts Grant , Shamy Michel , Momoli Franco , Aviv Richard , Demchuk Andrew M. , Chakraborty Santanu 
Published: November 2020

Abstract
The CT-angiography (CTA) spot sign is a predictor of hematoma expansion (HE). We have previously reported on the use of dynamic CTA (dCTA) to detect spot sign, and to study its formation over the acquisition period. In this study, we report the frequency of dCTA spot sign in acute intracerebral hemorrhage, its sensitivity and specificity to predict HE, and explore the rate of contrast extravasation in relation to hematoma growth.
We enrolled consecutive patients presenting with primary intracerebral hemorrhage within 4.5 hours. All patients underwent a dCTA protocol acquired over 60 seconds following contrast injection. We calculated frequency of the dCTA spot sign, predictive performance, and rate of contrast extravasation. We compared extravasation rates to the dichotomous definition of significant HE (defined as 6 mL or 33% growth).
In 78 eligible patients, dCTA spot sign frequency was 44.9%. In 61 patients available for expansion analysis, sensitivity and specificity of dCTA spot sign was 65.4% and 62.9%, respectively. Contrast extravasation rate did not significantly predict HE (Odds Ratio 15.6 for each mL/min [95% confidence interval 0.30–820.25], P = .17). Correlation between extravasation rate and HE was low (r = 0.297, P= .11). Patients with significant HE had a higher rate of extravasation as compared to those without (0.12 mL/min vs 0.04 mL/min, P = .03).
Dynamic CTA results in a higher frequency of spot sign positivity, but with modest sensitivity and specificity to predict expansion. Extravasation rate is likely related to HE, but a single measurement may be insufficient to predict the magnitude of expansion.
Effect of acupuncture of sphenopalatine ganglion for the treatment of allergic rhinitis
Authors: Xiong PeiYu , Yuan Tao , Xu Lu , Jia Bo 
Published: November 2020

Abstract

Background:
Allergic rhinitis is an allergic disease of the nasal mucosa mediated by IgE after the body is exposed to allergens. Acupuncture of sphenoid ganglion is a new technique developed by Professor Li Xinwu in the 1860 s to treat allergic rhinitis the efficacy of acupuncture on the sphenopalatine ganglion in the treatment of AR has been clinically verified, but a systematic review and meta-analysis of them is lacking. Our purpose is to evaluate the efficacy and safety of acupuncture on the sphenopalatine ganglion in the treatment of AR.

Methods:
We will search 8 electronic databases, including: Web of Science, PubMed, Cochrane Library, Embase, CNKI, CBM, Wanfang, VIP, WHO ICTRP, ChiCTR, Clinical Trials, Grey Literature Database. The literature search, screening and extraction will be carried out independently by 2 researchers. When the opinions are not uniform, it depends on the opinion of the third researcher. We will use RevmanV.5.3 to perform a fixed-effect meta-analysis on the date of clinical homogeneity studies, and the level of evidence will pass GRADE method.

Results:
This systematic review and meta-analysis will put a high-quality synthesis of the efficacy and safety of acupuncture of sphenoid ganglion treatment in AR.

Conclusion:
The review will provide a comprehensive basis for the treatment of AR patients with acupuncture on the sphenopalatine ganglion.

Ethics and dissemination:
Since this article does not involve patient privacy, ethical approval is not required.

Trial registration number:
INPLASY2020100067.