bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tertiary amine-catalyzed generation of chlorine dioxide from hypochlorous acid and chlorite ions
Authors: Isaza Ferro Estefania , Perrin Jordan , Dawson Owain George John , Vuorinen Tapani 
Published: November 2020

AbstractThe reaction between hypochlorous acid and chlorite ions is the rate limiting step for in situ chlorine dioxide regeneration. The possibility of increasing the speed of this reaction was analyzed by the addition of tertiary amine catalysts in the system at pH 5. Two amines were tested, DABCO (1,4-diazabicyclo[2.2.2]octane) and its derivative CEM-DABCO (1-carboethoxymethyl-1-azonia-4-aza-bicyclo[2.2.2]octane chloride). The stability of the catalysts in the presence of both reagents and chlorine dioxide was measured, with CEM-DABCO showing to be highly stable with the mentioned chlorine species, whereas DABCO was rapidly degraded by chlorine dioxide. Hence, CEM-DABCO was chosen as a suitable candidate to catalyze the reaction of hypochlorous acid with chlorite ions and it significantly increased the speed of this reaction even at low catalyst dosages. This research opens the door to a faster regeneration of chlorine dioxide and an improved efficiency in chlorine dioxide treatments.
Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (edition 2.1)
Authors:   Japanese Society of Medical Oncology, Naito Yoichi ,   Japan Society of Clinical Oncology,   Japanese Cancer Association, Aburatani Hiroyuki , Amano Toraji , Baba Eishi , Furukawa Toru , Hayashida Tetsu , Hiyama Eiso , Ikeda Sadakatsu , Kanai Masashi , Kato Motohiro , Kinoshita Ichiro , Kiyota Naomi , Kohno Takashi , Kohsaka Shinji , Komine Keigo , Matsumura Itaru , Miura Yuji , Nakamura Yoshiaki , Natsume Atsushi , Nishio Kazuto , Oda Katsutoshi , Oda Naoyuki , Okita Natsuko , Oseto Kumiko , Sunami Kuniko , Takahashi Hideaki , Takeda Masayuki , Tashiro Shimon , Toyooka Shinichi , Ueno Hideki , Yachida Shinichi , Yoshino Takayuki , Tsuchihara Katsuya 
Published: November 2020

Abstract
Background
To promote precision oncology in clinical practice, the Japanese Society of Medical Oncology, the Japanese Society of Clinical Oncology, and the Japanese Cancer Association, jointly published “Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment” in 2017. Since new information on cancer genomic medicine has emerged since the 1st edition of the guidance was released, including reimbursement for NGS-based multiplex gene panel tests in 2019, the guidance revision was made.

Methods
A working group was organized with 33 researchers from cancer genomic medicine designated core hospitals and other academic institutions. For an impartial evaluation of the draft version, eight committee members from each society conducted an external evaluation. Public comments were also made on the draft. The finalized Japanese version was published on the websites of the three societies in March 2020.

Results
The revised edition consists of two parts: an explanation of the cancer genomic profiling test (General Discussion) and clinical questions (CQs) that are of concern in clinical practice. Particularly, patient selection should be based on the expectation that the patient's post-test general condition and organ function will be able to tolerate drug therapy, and the optimal timing of test should be considered in consideration of subsequent treatment plans, not limited to treatment lines.

Conclusion
We expect that the revised version will be used by healthcare professionals and will also need to be continually reviewed in line with future developments in cancer genome medicine.
On the spore ornamentation of the microsoroid ferns (microsoroideae, polypodiaceae)
Authors: Chen Chi-Chuan , Liu Ho-Yih , Chen Cheng-Wei , Schneider Harald , Hyvönen Jaakko 
Published: November 2020

AbstractMicrosoroideae is the third largest of the six subfamilies of Polypodiaceae, containing over 180 species. These ferns are widely distributed in the tropical and subtropical regions of the Old World and Oceania. We documented the spore ornamentation and integrated these data into the latest phylogenetic hypotheses, including a sampling of 100 taxa representing each of 17 major lineages of microsoroid ferns. This enabled us to reconstruct the ancestral states of the spore morphology. The results show verrucate ornamentation as an ancestral state for Goniophlebieae and Lecanoptereae, globular for Microsoreae, and rugulate surface for Lepisoreae. In addition, spore ornamentation can be used to distinguish certain clades of the microsoroid ferns. Among all five tribes, Lecanoptereae show most diversity in spore surface ornamentation.
Improved detection of sentinel lymph node metastases allows reliable intraoperative identification of patients with extended axillary lymph node involvement in early breast cancer
Authors: Cotarelo Cristina L. , Zschöck-Manus Annemarie , Schmidt Marcus , Schad Arno , Brochhausen Christoph , Kirkpatrick Charles James , Thaler Sonja 
Published: November 2020

Abstract
Background
An improved procedure that allows accurate detection of negative sentinel lymph node (SLN) and of SLN macrometastases during surgery would be highly desirable in order to protect patients from further surgery and to avoid unnecessary costs. We evaluated the accuracy of an intraoperative procedure that combines touch imprint cytology (TIC) and subsequent frozen section (FS) analysis. 2276 SLNs from 1072 patients with clinical node-negative early breast cancer were evaluated during surgery using TIC. Only cytologically-positive SLN were subsequently analysed with a single FS, preserving cytologically-negative SLN for the final postoperative histological diagnosis. Sensitivity, specificity and the accuracy of this approach were analysed by comparing the results from intra- and postoperative SLN and axillary node evaluation. This intraoperative method displayed 100% specificity for SLN metastases and was significantly more sensitive for prognostically relevant macrometastases (85%) than for micrometastases (10%). Sensitivity was highest for patients with two or more positive LNs (96%) than for those with only one (72%). 98% of the patients with final pN2a-pN3a were already identified during surgery. Patients who received primary axillary lymph node dissection had significantly more frequent metastases in further LNs (44.6%). Sensitivity was highest for patients with luminal-B, HER2+ and triple negative breast cancer and for any subtype if Ki-67 > 40%. TIC and subsequent FS of cytologically-positive SLNs is highly reliable for detection of SLN macrometastases, and allows accurate identification of patients with a high risk of extended axillary involvement during surgery, as well as accurate histological diagnosis of negative SLN.
Welfare without rent seeking? Buchanan’s demogrant proposal and the possibility of a constitutional welfare state
Authors: Lehto Otto , Meadowcroft John 
Published: November 2020

AbstractIn a number of works, James M. Buchanan set out a proposal for a ‘demogrant’—a form of universal basic income that applied the principles of generality and non discrimination to the tax and the transfer sides of the scheme and was to be implemented as a constitutional rule outside the realm of day-to-day politics. The demogrant has received surprisingly little scholarly attention, but this article locates it in Buchanan’s broader constitutional political economy project and shows it was a logical application of his theoretical framework to the problem of inefficient and unfair welfare systems when reform to the basic institutions of majoritarian democracy was not forthcoming. The demogrant aims to end the problems of majority cycling and rent seeking that plague contemporary welfare states and therefore offers a model of welfare without rent seeking—a constitutional welfare state. We compare Buchanan’s demogrant model to other universal basic income and negative income tax models and consider the most important criticisms. We conclude that rescuing the demogrant model from relative obscurity would be a fruitful future task of applied constitutional political economy and public choice.
Separatrix crossing and symmetry breaking in NLSE-like systems due to forcing and damping
Authors: Eeltink D. , Armaroli A. , Luneau C. , Branger H. , Brunetti M. , Kasparian J. 
Published: November 2020

AbstractWe theoretically and experimentally examine the effect of forcing and damping on systems that can be described by the nonlinear Schrödinger equation (NLSE), by making use of the phase-space predictions of the three-wave truncation. In the latter, the spectrum is truncated to only the fundamental frequency and the upper and lower sidebands. Our experiments are performed on deep water waves, which are better described by the higher-order NLSE, the Dysthe equation. We therefore extend our analysis to this system. However, our conclusions are general for NLSE systems. By means of experimentally obtained phase-space trajectories, we demonstrate that forcing and damping cause a separatrix crossing during the evolution. When the system is damped, it is pulled outside the separatrix, which in the real space corresponds to a phase-shift of the envelope and therefore doubles the period of the Fermi–Pasta–Ulam–Tsingou recurrence cycle. When the system is forced by the wind, it is pulled inside the separatrix, lifting the phase-shift. Furthermore, we observe a growth and decay cycle for modulated plane waves that are conventionally considered stable. Finally, we give a theoretical demonstration that forcing the NLSE system can induce symmetry breaking during the evolution.
First steps in PROMs and PREMs collection in Wales as part of the prudent and value-based healthcare agenda
Authors: Withers Kathleen , Palmer Robert , Lewis Sally , Carolan-Rees Grace 
Published: November 2020

AbstractPurposePatients are experts in their own health and should be treated as equal partners in their care. Patient-reported outcome measures (PROMs) are an effective way of gathering patient feedback and can facilitate effectiveness and cost-effectiveness analysis to improve decision making and service improvement. The PROMs, PREMs & Effectiveness Programme was initiated in 2016 and aimed to develop an electronic platform to facilitate collection of PROMs and Patient-reported experience measures (PREMs) from secondary care patients across Wales.MethodsWe worked with all Health Boards in Wales, the NHS Wales Informatics Service (NWIS), and Cedar (a healthcare technology research centre) to identify and meet technical requirements to develop a platform which is fit for purpose. Patient groups were included throughout the development to gather feedback and for extensive testing. Clinical teams helped identify the most appropriate tools, with licences, translations and electronic formatting issues being managed centrally.ResultsThe developed platform is integrated with patient administration systems minimising the need for manual input, with processes in place to allow automatic collection triggers according to nationally agreed schedules. We have over 30 nationally agreed PROMs ‘pathways’ with over 110,000 PROMs collected to date. Responses are fed back to clinicians via the electronic patient record and to each health board via feeds to the national data warehouse, making data easily accessible to different teams, maximising use and application.DiscussionThe national platform has provided a co-ordinated approach to PROMs collection in Wales, offering an effective means of communicating with patients outside the traditional clinic visit.
The Value of Autonomy for the Good Life. An Empirical Investigation of Autonomy and Life Satisfaction in Europe
Authors: Steckermeier Leonie C. 
Published: November 2020

AbstractThis paper examines the association of opportunity and choice enhancing societal conditions and perceived autonomy with life satisfaction in Europe. Building on the capability approach, I investigate whether the positive effects of six basic functionings—safety, friendship, health, financial security, leisure, and respect—on people’s life satisfaction are weaker when people have more opportunity and choice. This paper addresses two main questions: (1) Are people more satisfied with their life when they have more opportunity and choice? (2) Do basic functionings play a smaller role for life satisfaction in societies that enable more opportunity and choice and for individuals with more perceived autonomy? The analyses are based on the European Quality of Life Survey (2016), covering 36,460 individuals in 33 European countries and using multilevel linear regressions. My study finds that both choice and opportunity enhancing societal conditions and individual’s perceived autonomy are positively associated with on life satisfaction. Further, all six basic functionings are conducive to individual life satisfaction. The positive effects of health, financial security, respect, and friendship are reduced when people experience a great deal of autonomy over their lives. Societal conditions that provide people with more opportunity and choice further lower the positive effects of financial security, leisure, respect, and safety on individual life satisfaction. This corroborates the importance the capability approach attributes to individual opportunities and freedom of choice.
The State-of-the-Art of Urban Climate Change Modeling and Observations
Authors: Hamdi Rafiq , Kusaka Hiroyuki , Doan Quang-Van , Cai Peng , He Huili , Luo Geping , Kuang Wenhui , Caluwaerts Steven , Duchêne François , Van Schaeybroek Bert , Termonia Piet 
Published: November 2020

AbstractAs an effect of climate change, cities need detailed information on urban climates at decision scale that cannot be easily delivered using current observation networks, nor global and even regional climate models. A review is presented of the recent literature and recommendations are formulated for future work. In most cities, historical observational records are too short, discontinuous, or of too poor quality to support trend analysis and climate change attribution. For climate modeling, on the other hand, specific dynamical and thermal parameterization dedicated to the exchange of water and energy between the atmosphere and the urban surfaces have to be implemented. Therefore, to fully understand how cities are impacted by climate change, it is important to have (1) simulations of the urban climate at fine spatial scales (including coastal hazards for coastal cities) integrating global climate scenarios with urban expansion and population growth scenarios and their associated uncertainty estimates, (2) urban climate observations, especially in Global South cities, and (3) spatial data of high resolution on urban structure and form, human behavior, and energy consumption.
The impact of music making outdoors on primary school aged pupils (aged 7–10 years) in the soundscape of nature from the perspective of their primary school teachers
Authors: Adams Dylan , Beauchamp Gary 
Published: December 2020

AbstractThe benefits of taking pupils’ learning outdoors have been widely reported around the world. However, it is argued the simple act of stepping outside the classroom does not inevitably bring rewards. This study examines teachers’ perceptions of the impact of primary school pupils’ music-making in various outdoor rural locations. It analyses qualitative data from semi-structured interviews with seven teachers from six different primary school classes, who observed their classes as they took part in the music-making. The validity of the teachers’ perceptions is triangulated with evidence from semi-structured interviews with six groups of children from the six different classes. The analyses show the teachers perceived that the space, the new soundscape and the close contact with nature afforded by the different locations engendered enhanced experimentation and expressiveness. The teachers suggested that, as a result, the children became immersed in, and focussed on, their music-making. The study suggests teachers identify potential benefits for children aged 7–10 years in making music in outdoor locations. We conclude greater phenomenological, body-focussed understandings in education and an increased awareness of somaesthetic perspectives may be beneficial for teachers to explore in pupils’ music- making and in other creative areas of the curriculum.
A Bayesian sequential test for the drift of a fractional Brownian motion
Authors: Muravlev Alexey , Zhitlukhin Mikhail 
Published: December 2020

AbstractWe consider a fractional Brownian motion with linear drift such that its unknown drift coefficient has a prior normal distribution and construct a sequential test for the hypothesis that the drift is positive versus the alternative that it is negative. We show that the problem of constructing the test reduces to an optimal stopping problem for a standard Brownian motion obtained by a transformation of the fractional Brownian motion. The solution is described as the first exit time from some set, and it is shown that its boundaries satisfy a certain integral equation, which is solved numerically.
River Sediment Geochemistry as a Conservative Mixture of Source Regions: Observations and Predictions From the Cairngorms, UK
Authors: Lipp Alex G. , Roberts Gareth G. , Whittaker Alexander C. , Gowing Charles J. B. , Fernandes Victoria M. 
Published: November 2020

AbstractThe elemental composition of sediments in rivers is the product of physical and chemical erosion of rocks, which is then transported across drainage networks. A corollary is that fluvial sedimentary geochemistry can be used to understand geologic, climatic, and geomorphic processes. Here, we predict elemental compositions of river sediments using drainage networks extracted from digital elevation data and erosional models. The Geochemical Baseline Survey of the Environment was used to quantify substrate (i.e., source region) chemistry. Sedimentary compositions in rivers downstream are predicted by formally integrating eroding substrates with respect to distance downstream. Different erosional models, including the Stream Power model and uniform incision rates, are tested. Predictions are tested using a new suite of compositions obtained from fine grained (<150 μm) sediments at 67 sites along the Spey, Dee, Don, Deveron, and Tay rivers, Cairngorms, UK. Results show that sedimentary geochemistry can be predicted using simple models that include the topography of drainage networks and substrate compositions as input. The concentration of numerous elements including Magnesium, Rubidium, Uranium, Potassium, Calcium, Strontium, and Beryllium can be accurately predicted using this simple approach. Predictions are insensitive to the choice of erosional model, which we suggest is a consequence of broadly homogeneous rates of erosion throughout the study area. Principal component analysis of the river geochemical data suggests that the composition of most Cairngorms river sediments can be explained by mafic/felsic provenance and conservative mixing downstream. These results suggest that the elemental composition of river sediments can be accurately predicted using simple erosional models and digital elevation data.
Hypoxia induces sorafenib resistance mediated by autophagy via activating FOXO3a in hepatocellular carcinoma
Authors: Liang Chao , Dong Zhebin , Cai Xianlei , Shen Jie , Xu Yuan , Zhang Miaozun , Li Hong , Yu Weiming , Chen Wei 
Published: November 2020

AbstractSorafenib, a multikinase inhibitor, is considered as the only approved drug to cure the advanced hepatocellular carcinoma (HCC); however, the acquired chemoresistance caused by intratumoral hypoxia through sorafenib long term therapy induces sorafenib inefficacy. We demonstrated here that hypoxia significantly attenuated sensitivity of HCC cells to sorafenib treatment and reduced its proliferation. Autophagy was observed in sorafenib-treated HCC cells in hypoxia, and inhibition of autophagy by 3-MA eliminated hypoxia-induced sorafenib resistance. Further study revealed hypoxia-activated FOXO3a, an important cellular stress transcriptional factor, via inducing its dephosphorylation and nuclear location; and FOXO3a-dependent transcriptive activation of beclin-1 was responsible for hypoxia-induced autophagy in HCC cells. Knockout of FOXO3a inhibited the autophagy induced by sorafenib itself in normoxia and significantly enhanced the cytotoxicity of sorafenib in HCC cells; and it also inhibited the hypoxia-induced autophagy and achieved the same effect in sorafenib sensitivity-enhancement in HCC cells as it in normoxia. Finally, knockout of intratumoral FOXO3a significantly enhanced curative efficacy of sorafenib via inhibition of autophagy in xenograft tumors in nude mice. Collectively, our study suggests that FOXO3a plays a key role in regulating hypoxia-induced autophagy in sorafenib-treated HCC, and FOXO3-targeted therapy may serve as a promising approach to improve clinical prognosis of patients suffering from HCC.
The ZNF750–RAC1 axis as potential prognostic factor for breast cancer
Authors: Butera Alessio , Cassandri Matteo , Rugolo Francesco , Agostini Massimiliano , Melino Gerry 
Published: November 2020

AbstractThe human zinc finger (C2H2-type) protein ZNF750 is a transcription factor regulated by p63 that plays a critical role in epithelial tissues homoeostasis, as well as being involved in the pathogenesis of cancer. Indeed, missense mutations, truncation and genomic deletion have been found in oesophageal squamous cell carcinoma. In keeping, we showed that ZNF750 negatively regulates cell migration and invasion in breast cancer cells; in particular, ZNF750 binds and recruits KDM1A and HDAC1 on the LAMB3 and CTNNAL1 promoters. This interaction, in turn, represses the transcription of LAMB3 and CTNNAL1 genes, which are involved in cell migration and invasion. Given that ZNF750 is emerging as a crucial transcription factor that acts as tumour suppressor gene, here, we show that ZNF750 represses the expression of the small GTPase, Ras-related C3 botulinum toxin substrate 1 (RAC1) in breast cancer cell lines, by directly binding its promoter region. In keeping with ZNF750 controlling RAC1 expression, we found an inverse correlation between ZNF750 and RAC1 in human breast cancer datasets. More importantly, we found a significant upregulation of RAC1 in human breast cancer datasets and we identified a direct correlation between RAC1 expression and the survival rate of breast cancer patient. Overall, our findings provide a novel molecular mechanism by which ZNF750 acts as tumour suppressor gene. Hence, we report a potential clinical relevance of ZNF750/RAC1 axis in breast cancer.