bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organizational empowerment: A framework examining historical and systemic domains in school settings
Authors: Gooden Adia , Keys Christopher B. , Back Lindsey , McMahon Susan D. , Morgan Michele 
Published: November 2020

AbstractOrganizational empowerment (OE) is a key construct in community psychology. We build on current understandings of OE by exploring history and systemic relationships as important aspects of OE. We conducted interviews with 20 school leaders from 16 schools that went through a district‐wide transition of students with disabilities into general education schools and asked these leaders about their preparation and service provision during this transition. We utilized a grounded theory approach to analyze the data, and two domains of OE emerged: historical and systemic, each with multiple dimensions. The historical domain refers to schools' functioning before the transition, and the systemic domain reflects interactions between schools and the School District Office for Students with Disabilities during the transition. We provide a nuanced understanding of these domains of organizational empowerment and their interaction, as well as implications for empowerment theory and practice.
Temperature‐induced mutagenesis‐based adaptive evolution of Bacillus amyloliquefaciens for improving the production efficiency of menaquinone‐7 from starch
Authors: Liu Ning , Ruan Haozhe , Liu Liming , Zhang Weiguo , Xu Jianzhong 
Published: November 2020

AbstractBACKGROUNDStarch can be used as a carbon source for producing menaquinone‐7 (MK‐7) by Bacillus sp., but the final titer and productivity are unsatisfactory because starch cannot be effectively hydrolyzed to fermentable sugars. This article focuses on developing thermo‐tolerable MK‐7 high‐producing strains by temperature‐induced mutagenesis‐based adaptive evolution.RESULTSHere, we isolated a thermo‐tolerable MK‐7 high‐producing strain B. amyloliquefaciens MK50‐36 after multi‐rounds of acclimation at high temperature. Strain MK50‐36 showed a large growth with soluble starch as carbon source at 50 °C. Compared with the parental strain B. amyloliquefaciens H.β.D.R.‐5 cultivated at 37 °C, MK‐7 yield of strain MK50‐36 increased about twofold at 50 °C when soluble starch was used as the sole carbon resource (17.5 ± 1.5 mg L–1 versus 37.1 ± 2.1 mg L–1). In addition, strain MK50‐36 showed an improvement in starch utilization rate as compared with strain H.β.D.R.‐5 because α‐amylase activity of strain MK50‐36 was the highest at 50 °C. Moreover, MK‐7 yield of strain MK50‐36 was further increased by feeding fresh broth to control the amount of fermentation liquid in fed‐batch fermentation because fermentation broth will be easy to volatilize and thus affect the production of MK‐7 at high temperature, which reached up to 52.7 ± 4.6 mg L–1.CONCLUSIONThese results indicated that soluble starch can act as an effective carbon source for producing MK‐7, and strain MK50‐36 has a superior capacity to produce MK‐7 from soluble starch. © 2020 Society of Chemical Industry
The role of orotic acid measurement in routine newborn screening for urea cycle disorders
Authors: Staretz‐Chacham Orna , Daas Suha , Ulanovsky Igor , Blau Ayala , Rostami Nira , Saraf‐Levy Talya , Abu Salah Nasser , Anikster Yair , Banne Ehud , Dar Dalit , Dumin Elena , Fattal‐Valevski Aviva , Falik‐Zaccai Tzipora , Hershkovitz Eli , Josefsberg Sagi , Khammash Hatem , Keidar Rimona , Korman Stanley H. , Landau Yuval , Lerman‐Sagie Tally , Mandel Dror , Mandel Hanna , Marom Ronella , Morag Iris , Nadir Erez , Yosha‐Orpaz Naama , Pode‐Shakked Ben , Pras Elon , Reznik‐Wolf Haike , Saada Ann , Segel Reeval , Shaag Avraham , Shaul Lotan Nava , Spiegel Ronen , Tal Galit , Vaisid Taly , Zeharia Avi , Almashanu Shlomo 
Published: November 2020

AbstractUrea cycle disorders (UCDs), including OTC deficiency (OTCD), are life‐threatening diseases with a broad clinical spectrum. Early diagnosis and initiation of treatment based on a newborn screening (NBS) test for OTCD with high specificity and sensitivity may contribute to reduction of the significant complications and high mortality. The efficacy of incorporating orotic acid determination into routine NBS was evaluated. Combined measurement of orotic acid and citrulline in archived dried blood spots from newborns with urea cycle disorders and normal controls was used to develop an algorithm for routine NBS for OTCD in Israel. Clinical information and genetic confirmation results were obtained from the follow‐up care providers. About 1147986 newborns underwent routine NBS including orotic acid determination, 25 of whom were ultimately diagnosed with a UCD. Of 11 newborns with OTCD, orotate was elevated in seven but normal in two males with early‐onset and two males with late‐onset disease. Orotate was also elevated in archived dried blood spots of all seven retrospectively tested historical OTCD patients, only three of whom had originally been identified by NBS with low citrulline and elevated glutamine. Among the other UCDs emerge, three CPS1D cases and additional three retrospective CPS1D cases otherwise reported as a very rare condition. Combined levels of orotic acid and citrulline in routine NBS can enhance the detection of UCD, especially increasing the screening sensitivity for OTCD and differentiate it from CPS1D. Our data and the negligible extra cost for orotic acid determination might contribute to the discussion on screening for proximal UCDs in routine NBS.
Intracranial recordings reveal ubiquitous in‐phase and in‐antiphase functional connectivity between homotopic brain regions in humans
Authors: O’Reilly Christian , Elsabbagh Mayada 
Published: November 2020

AbstractWhether neuronal populations exhibit zero‐lag (in‐phase or in‐antiphase) functional connectivity is a fundamental question when conceptualizing communication between cell assemblies. It also has profound implications on how we assess such interactions. Given that the brain is a delayed network due to the finite conduction velocity of the electrical impulses traveling across its fibers, the existence of long‐distance zero‐lag functional connectivity may be considered improbable. However, in this study, using human intracranial recordings we demonstrate that most interhemispheric connectivity between homotopic cerebral regions is zero‐lagged and that this type of connectivity is ubiquitous. Volume conduction can be safely discarded as a confounding factor since it is known to drop almost completely within short interelectrode distances (<20 mm) in intracranial recordings. This finding should guide future electrophysiological connectivity studies and highlight the importance of considering the role of zero‐lag connectivity in our understanding of communication between cell assemblies.
Ethical marketer and sustainability: Facing the challenges of overconsumption and the market
Authors: Ardley Barry , May Claire 
Published: November 2020

AbstractBased on environmentally informed marketing strategies, Anthony Giddens' theory of structuration is used to develop new business models that address the twin problems of contemporary capitalism, namely consumer overconsumption and sustainability. Central to the effective implementation of new business models is the individual ethical marketer who acts as an interface between the market, the consumer, and the practices of organizations. Sustainable marketing has to be implemented through the actions of individual marketers, customers, and the institutional system, to avoid what has been heralded as planet Earth's sixth extinction. Giddens theory is used in a practical way to guide the development of a new three‐element marketing policy framework.
Public–private merger integration as a dynamic process of legitimation
Authors: Thelisson Anne‐Sophie , Meier Olivier 
Published: November 2020

AbstractLegitimation during post‐merger integration is a challenging nonlinear process influenced by the key public, private, and hybrid dynamics. In contrast to the planned characterization of merger integration, legitimation is a nonlinear process. Legitimacy is crucial to organizational change, especially in the context of a merger; managers need to understand the oscillating dynamics from public and private logics during the integration period. The legitimation process during a merger comprises three key processes: public, private, and hybrid. These are tools for managers involved in a public–private integration.
World of male and female entrepreneurs: Findings from a global study
Authors: Sharma Shilpi , Sahni Sanjeev P. 
Published: November 2020

AbstractAn individual's gender may influence their behavioral preferences as males exhibited a significantly higher risk taking, openness to change, autonomy, and achievement tendencies. Interestingly, older females seemed to possess lower risk taking, creativity, and autonomy than the younger cohort of women entrepreneurs, while age had no influence on personality attributes of male respondents. An entrepreneur's personality preferences were uninfluenced by whether an established business is earning revenue or designed as a profit or nonprofit venture.
Capitalism leading to unhealthy food consumption
Authors: Hasan Rajibul , YU Zhirun 
Published: November 2020

AbstractHow fast‐food and beverage companies, which are driven by capitalism, adopt the ethical product, price, promotion, and place strategies to influence consumers' perceived value and purchase intentions. Results from hypotheses testing show the ethical aspects of fast food and beverage companies' marketing strategies highly influence consumers' perceived value of products and further prove perceived value positively influences consumers' purchase intentions. These findings will educate fast food and carbonated beverage companies on the ethical problems of marketing unhealthy foods. Our results also lead to fast food and carbonated beverage companies to reconsider their marketing strategies for the improvement of this serious situation that can be tied to capitalism.
Networking and strategic planning to enhance small and medium‐sized enterprises growth in a less competitive economy
Authors: Clifton Nick , Huggins Robert , Pickernell David , Prokop Daniel , Smith David , Thompson Piers 
Published: November 2020

AbstractCompetition and day‐to‐day firefighting prevents small businesses from undertaking the most effective types of strategic planning and networking for growth and innovation. Poor or inappropriate execution of these activities highlights the need for targeted managerial training. Potential explanations for the weak growth of many SMEs focus on the limited use of strategic planning and networking activities. Data from a management survey of SMEs in South East Wales shows that where these activities are undertaken the type of networking and information sought from it is often not that most associated with innovation and growth. Therefore, it may not be their absence per se, but the poor or inappropriate execution of these activities that is the key problem. This deficiency highlights the need for targeted managerial training in these areas.
Study on the dynamic response of dip bedded rock slope using discontinuous deformation analysis (DDA) and shaking table tests
Authors: Feng Xixia , Jiang Qinghui , Zhang Huichao , Zhang Xiaobo 
Published: November 2020

AbstractStability prediction for bedded rock slopes under seismic loading is very important for landslide hazard assessment. To clarify the dynamic behaviors and damage mechanism of dip bedded slope, shaking table tests and its prototype simulation analyses were performed. Shaking table tests were conducted to analysis the acceleration dynamic response firstly and then the discontinuous deformation analysis (DDA) method was used to reproduce the test results, and study the influence of vertical earthquake on the dynamic response of dip bedded rock slope. Both the two methods results reveal that the amplification coefficients increase with increasing acceleration amplitude under sinusoidal waves shaking condition, and show an increased trend with the relation height. With Wenchaun waves loading, the discontinuous characteristics between the test model and numerical model are consistent, the dynamic responses of the slope tops are strong, and it is easy to be destroyed. Compare the failure mechanism of the slope between shaking table test and numerical method, the damage areas both the numerical model and test model are the nearly identical, and the failure modes of two models are mainly the cracking sliding failure. Moreover, with horizontal and vertical earthquake loading, the acceleration response on the numerical slope top is strong, and the maximum peak acceleration amplification factors are at the leading and rear edges of the slope top. In overall, the dynamic response of the slope surface is more significant than that inside the slope. However, with an increase of amplitude, acceleration responses are different with different directional loading, the acceleration response with horizontal loading is stronger than with vertical loading.
“In the back of my mind, time always ticks one hour forward”: The transnational temporalities of Moldovan domestic workers in Italy
Authors: Cojocaru Olga 
Published: November 2020

AbstractThis article analyses the temporalities of transnational living through a threefold frame: as an outlook, as a resource and as a qualitative experience. Drawing on data from interviews with Moldovan women who are domestic workers in Italy, I point to the time work employed by these labour migrants to navigate a multitude of timescapes derived from a (permanently) temporary status, precarious resources and the emotional ambivalence that arises from being away from their families. I show how migrants' envisioned temporariness of transnational living materialises into a time‐bound outlook, which, in turn, compels them to manage time as a scarce resource, that has to be managed, planned and worked with. Lastly, I indicate that maintaining a temporary outlook correlates with a halting strategy and may have significant effects on personal and family well‐being.
Atezolizumab‐induced fulminant type 1 diabetes mellitus occurring four months after treatment cessation
Authors: Nishioki Toshihiko , Kato Motoyasu , Kataoka Shunichi , Miura Keita , Nagaoka Tetsutaro , Takahashi Kazuhisa 
Published: November 2020

AbstractAtezolizumab is an immune checkpoint inhibitor (ICI) that is often associated with the development of several immune‐related adverse events, including fulminant type 1 diabetes mellitus (F1DM). Here, we present the case of a 73‐year‐old woman who was diagnosed with lung adenocarcinoma after surgical lung lobectomy. Two years later, she developed pulmonary metastasis, and atezolizumab treatment was initiated after seven years. However, she only completed two cycles of atezolizumab treatment because of disease progression. Four months after the interruption of atezolizumab treatment, she presented to the emergency department with fatigue and vomiting. On admission, she had a serum glucose level of 962 mg/dL, metabolic acidosis, and elevated ketone body levels. She was diagnosed with diabetic ketoacidosis induced by atezolizumab treatment. Her symptoms improved by insulin therapy. When ICIs are administered, care should be taken regarding the development of F1DM.
Bletilla striata Polysaccharides Improve Hemostatic, Antiinflammatory Efficacy, and Platelet Aggregation in Gingivitis Rat Model
Authors: Guo Qing , Li Bailei , Bao Chunling , Li Yixia , Cao Yuling , Wang Chunxiao , Wu Wenhui 
Published: November 2020

AbstractIn this study, the bioactivity of the Bletilla striata polysaccharides (BSPS) on platelet aggregation and anti‐inflammation is investigated. For this purpose, a physiological system in vitro is established to evaluate the hemostatic effect of BSPS by measuring the platelet aggregation (PAG) rate, cyclic adenosine monophosphate (cAMP), and thromboxane B2 (TXB2). A quantifiable inflammatory model of human gingival epithelial cells (HGECs) is established by inducing lipopolysaccharide (LPS) to evaluate the anti‐inflammatory effect of BSPS. An experimental gingivitis rat model in vivo is set up to further verify hemostatic and anti‐inflammatory efficacy of BSPS, which is comprehensively evaluated through the following five techniques: X‐ray morphological observation, hematoxylin‐eosin (HE) staining analysis, probe index (plaque index, gingival index, bleeding on probing) diagnostic evaluation, immunoglobulin (IgA, IgM, IgG), and cytokines. Interestingly, the changes of cytokines in vivo are in accordance with those in vitro. The positive effects of BSPS in hemostasis and anti‐inflammation are also confirmed by X‐ray observation and HE staining. The above results demonstrate that BSPS promotes platelet aggregation with an anti‐inflammatory effect, which suggests that the BSPS may be beneficial in the treatment of hemostasis and inflammatory diseases.
Per‐ and polyfluoroalkyl substances thermal destruction at water resource recovery facilities: A state of the science review
Authors: Winchell Lloyd J. , Ross John J. , Wells Martha J. M. , Fonoll Xavier , Norton John W. , Bell Katherine Y. 
Published: November 2020

AbstractPer‐ and polyfluoroalkyl substances (PFAS) are a recalcitrant group of chemicals and can be found throughout the environment. They often collect in wastewater systems with virtually no degradation prior to environmental discharge. Some PFAS partitions to solids captured in wastewater treatment which require further processing. Of all the commonly applied solids treatment technologies, incineration offers the only possibility to completely destroy PFAS. Little is known about the fate of PFAS through incineration, in particular, for the systems employed in water resource recovery facilities (WRRF). This review covers available research on the fate of PFAS through incineration systems with a focus on sewage sludge incinerators. This research indicates that at least some PFAS destruction will occur with incineration approaches used at WRRFs. Furthermore, PFAS in flue gas, ash, or water streams used for incinerator pollution control may be undetectable. Future research involving full‐scale fate studies will provide insight on the efficacy of PFAS destruction through incineration and whether other compounds of concern are generated.Practitioner pointsThermal processing is the only commercial approach available to destroy PFAS.Thermal degradation conditions required for destruction of PFAS during incineration processes are discussed.Fate of PFAS through water resource recovery facility incineration technologies remains unclear.Other thermal technologies such as smoldering combustion, pyrolysis, gasification, and hydrothermal liquefaction provide promise but are in developmental phases.
Genotype–Phenotype Associations in 72 Adults with Suspected ALPL-Associated Hypophosphatasia
Authors: Jandl Nico Maximilian , Schmidt Tobias , Rolvien Tim , Stürznickel Julian , Chrysostomou Konstantin , von Vopelius Emil , Volk Alexander E. , Schinke Thorsten , Kubisch Christian , Amling Michael , Barvencik Florian 
Published: November 2020

AbstractHypophosphatasia (HPP) is a rare inborn error of metabolism due to a decreased activity of tissue nonspecific alkaline phosphatase (TNSALP). As the onset and severity of HPP are heterogenous, it can be challenging to determine the pathogenicity of detected rare ALPL variants in symptomatic patients. We aimed to characterize patients with rare ALPL variants to propose which patients can be diagnosed with adult HPP. We included 72 patients with (1) clinical symptoms of adult HPP or positive family history and (2) low TNSALP activity and/or high pyridoxal 5′-phosphate (PLP) levels, who underwent ALPL gene sequencing. The patients were analyzed and divided into three groups depending on ALPL variant pathogenicity according to the classification of the American College of Medical Genetics and Genomics (ACMG). Reported pathogenic (n = 34 patients), rare (n = 17) and common (n = 21) ALPL variants only were found. Muscular complaints were the most frequent symptoms (> 80%), followed by bone affection (> 50%). Tooth involvement was significantly more common in patients with pathogenic or rare ALPL variants. Seven rare variants could be classified as likely pathogenic (ACMG class 4) of which five have not yet been described. Inconclusive genetic findings and less specific symptoms make diagnosis difficult in cases where adult HPP is not obvious. As not every pathogenic or rare ALPL variant leads to a manifestation of HPP, only patients with bone complications and at least one additional complication concerning teeth, muscle, central nervous and mental system, repeated low TNSALP activity and high PLP levels should be diagnosed as adult HPP if rare ALPL gene variants of ACMG class 4 or higher support the diagnosis.
Relationships Between Level and Change in Sarcopenia and Other Body Composition Components and Adverse Health Outcomes: Findings from the Health, Aging, and Body Composition Study
Authors: Westbury Leo D. , Syddall Holly E. , Fuggle Nicholas R. , Dennison Elaine M. , Harvey Nicholas C. , Cauley Jane A. , Shiroma Eric J. , Fielding Roger A. , Newman Anne B. , Cooper Cyrus 
Published: November 2020

AbstractWe investigated how baseline values and rates of decline in components of sarcopenia and other body composition parameters relate to adverse clinical outcomes using the Health, Aging, and Body Composition Study. 2689 participants aged 70–79 years were studied. Appendicular lean mass, whole body fat mass, and total hip BMD were ascertained using DXA; muscle strength by grip dynamometry; and muscle function by gait speed. Baseline values and 2–3 year conditional changes (independent of baseline) in each characteristic were examined as predictors of mortality, hospital admission, low trauma fracture, and recurrent falls in the subsequent 10–14 years using Cox regression (generalized estimating equations used for recurrent falls) with adjustment for sex, ethnicity, age, and potential confounders. Lower levels and greater declines in all parameters (excluding hip BMD level) were associated (p < 0.05) with increased rates of mortality; fully-adjusted hazard ratios per SD lower gait speed and grip strength were 1.27 (95% CI 1.19, 1.36) and 1.14 (1.07, 1.21), respectively. Risk factors of hospital admission included lower levels and greater declines in gait speed and grip strength, and greater declines in hip BMD. Lower levels and greater declines in fat mass and hip BMD were associated with low trauma fracture. Lower gait speed, higher fat mass, and both lower levels and greater declines in grip strength were related to recurrent falls. Lower baseline levels and greater declines in musculoskeletal parameters were related to adverse outcomes. Interventions to maximize peak levels in earlier life and reduce rates of age-related decline may reduce the burden of disease in this age group.