bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal study of the development of obstruent correctness from ages 3 to 5 years in 108 Danish children with unilateral cleft lip and palate: a sub‐study within a multicentre randomized controlled trial
Authors: Jørgensen Line Dahl , Willadsen Elisabeth 
Published: November 2019

AbstractBackgroundSpeech‐sound development in preschoolers with unilateral cleft lip and palate (UCLP) as a group is delayed/disordered, and obstruents comprise the most vulnerable sound class.AimsTo evaluate the development of obstruent correctness (PCC‐obs) and error types (cleft speech characteristics (CSCs) and developmental speech characteristics (DSCs)) from ages 3–5 and to investigate possible predictors (error types, velopharyngeal dysfunction (VPD) and gender) of PCC‐obs at age 5 in two groups of children with UCLP.Methods & ProceduresSubgroup analysis was conducted within a multicentre randomized controlled trial (RCT) of primary surgery (Scandcleft Project). A total of 125 Danish children with UCLP received lip and soft palate repair around 4 months of age and early hard palate closure at 12 months (EHPC group) or late hard palate closure at 36 months (LHPC group). Audio and video recordings of a naming test were available for 108 children at ages 3 and 5, and recordings were transcribed phonetically by blinded raters.Outcomes & ResultsPCC‐obs scores increased significantly from ages 3–5 in both groups, but with small effect sizes in the EHPC group that had higher scores at age 3 than the LHPC group. DSCs decreased in both groups whereas CSCs only decreased in the LHPC group that had more CSCs at age 3 than the EHPC group. The frequency of CSCs at age 3 was a significant predictor of PCC‐obs scores at age 5 in both groups. DSCs significantly improved the logistic regression model in the EHPC group, whereas VPD and gender did not significantly improve the model in either group.Conclusions & ImplicationsAlthough PCC‐obs developed significantly from ages 3 to 5, children with UCLP as a group did not catch up to typically developing Danish children at age 5. Furthermore, the LHPC group at age 5 did not reach the 3‐year level of the EHPC group, which means that delaying hard palate closure until age 3 is detrimental to obstruent development. Both CSCs and DSCs at age 3 were important predictors of PCC‐obs at age 5 and should be considered when determining need for intervention.
State Legislators’ Support for Behavioral Health Parity Laws: The Influence of Mutable and Fixed Factors at Multiple Levels
Authors: PURTLE JONATHAN , LÊ‐SCHERBAN FÉLICE , WANG XI , SHATTUCK PAUL T. , PROCTOR ENOLA K. , BROWNSON ROSS C. 
Published: November 2019

Policy Points
When communicating with state legislators, advocates for state behavioral health parity laws should emphasize that the laws do not increase insurance premiums.
Legislators’ opinions about the impacts of state behavioral health parity laws and the effectiveness of behavioral health treatment have more influence on support for the laws than do their political party affiliation or state‐level contextual factors.
Reducing legislators’ stigma toward people with mental illness could increase their support for state behavioral health parity laws
ContextComprehensive state behavioral health parity legislation (C‐SBHPL) is an evidence‐based policy that improves access and adherence to behavioral health treatments. However, adoption of C‐SBHPL by state legislators is low. Little is known about how C‐SBHPL evidence might be most effectively disseminated to legislators or how legislators’ fixed characteristics (eg, ideology), mutable characteristics (eg, beliefs about the policy's impact), and state‐level contextual factors might influence their support for behavioral health policies. The purpose of our study is (1) to describe the associations between legislators’ fixed and mutable characteristics, state‐level contextual factors, and support for C‐SBHPL; and (2) to identify the mutable characteristics of legislators independently associated with C‐SBHPL support.MethodsWe conducted a multimodal (post mail, email, telephone) survey of US state legislators in 2017 (N = 475). The dependent variable was strong support for C‐SBHPL, and the independent variables included legislators’ fixed and mutable characteristics and state‐level contextual factors. We conducted multivariable, multilevel (legislator, state) logistic regression.FindingsThirty‐nine percent of the legislators strongly supported C‐SBHPL. After adjustment, the strongest predictors of C‐SBHPL support were beliefs that C‐SBHPL increases access to behavioral health treatments (aOR = 5.85; 95% CI = 2.41, 14.20) and does not increase insurance premiums (aOR = 2.70; 95% CI = 1.24, 5.90). Stigma toward people with mental illness was inversely associated with support (aOR = 0.86; 95% CI = 0.78, 0.95). After adjustment, ideology was the only fixed characteristic significantly associated with support for C‐SBHPL. State‐level contextual factors did not moderate associations between mutable characteristics and support for C‐SBHPL.ConclusionsLegislators’ mutable characteristics are stronger predictors of C‐SBHPL support than are most of their fixed characteristics and all state‐level contextual factors, and thus should be targeted by dissemination efforts.
African American/white disparities in psychiatric emergencies among youth following rapid expansion of Federally Qualified Health Centers
Authors: Bruckner Tim A. , Singh Parvati , Yoon Jangho , Chakravarthy Bharath , Snowden Lonnie R. 
Published: November 2019

AbstractObjectiveTo test whether rapid expansion of mental health services in Federally Qualified Health Centers (FQHCs) reduces African American/white disparities in youth psychiatric emergency department (ED) visits.Data SourcesSecondary ED data for psychiatric care for 3.3 million African American and white youth in nine states, 2006‐2011. We used the HCUP SEDD and SID. We obtained FQHC service data from the Uniform Data System.Study DesignThe psychiatric ED visit is the dependent variable. Logistic regression methods control for individual risk factors for ED use, as well as county‐level health system factors and county and year fixed effects. Key independent variables include indicators of mental health service capacity in FQHCs in a county‐year.Data Extraction MethodsWe extracted ED psychiatric visits for 3.3 million African American and white youth in nine states, 2006‐2011, from the HCUP SEDD and SID, and FQHC data from the Uniform Data System.Principal FindingsOverall mental health visits at FQHCs correlate positively with psychiatric ED visits among African American youth. However, increases in the number of mental health visits per FQHC patient corresponds with fewer outpatient psychiatric ED visits among African American youth, relative to white youth (odds ratio = 0.96; 95% CI = 0.94, 0.98).ConclusionsIncreases in the intensity of services offered per mental health patient at FQHCs—rather than increases in overall capacity—may reduce African American youth's overreliance on the ED for psychiatric care.
Unusual Elevator‐Related Deaths: A Report of Two Cases
Authors: Sakelliadis Emmanouil I. , Katsos Konstantinos D. , Zouzia Evmorfili I. , Moraitis Konstantinos , Spiliopoulou Chara A. 
Published: November 2019

AbstractWe present two cases of elevator‐related deaths that occurred in two different elevators, and deaths were caused by a similar, but unusual, mechanism. An elevator is a platform or compartment housed in a shaft for raising and lowering people or things to different levels. Elevator‐related deaths and injuries are rarely reported in the literature. In most of these cases, cause of death was attributed to falls. It seems that most of the elevator accidents may be attributed to factors related to device maintenance inadequacies or even to device malfunctioning. In our cases, both elevator cars were not equipped with full‐length inner doors, thus allowing both accidents to occur. Since 2014, the European Union adopted a relative directive, which imposes the need to equip all elevators with such full‐length doors. The enforcement of the above‐mentioned EU Directive is crucial, in order to prevent similar accidents in the future.
Shelf‐Life Enhancement in Fresh and Frozen Rainbow Trout Fillets by the Employment of a Novel Active Coating Design
Authors: Zhaleh Saba , Shahbazi Yasser , Shavisi Nassim 
Published: November 2019

AbstractThe goal of this study was to determine the effect of incorporating ethanolic Prosopis farcta extract (PFE, 0 and 0.5%) and curcumin nanoparticles (CCM, 0, 0.1 and 0.2%) into sodium alginate (SA) coating on shelf‐life of refrigerated and frozen rainbow trout fillets during storage lasting for 12 days and 6 months, respectively. Antioxidant and antibacterial properties of designated coatings were examined using 2, 2‐diphenyl‐1‐picrylhydrazyl hydrate free radical scavenging activity and broth microdilution methods, respectively. The highest antioxidant and antibacterial activities were found in CCM 0.2% + PFE 0.5% and CCM 0.1% + PFE 0.5%. The CCM 0.2% + PFE 0.5% and CCM 0.1% + PFE 0.5% treatments could significantly extend the shelf‐life of fresh trout fillets for 12 days during refrigerated storage evidenced by the 3.6 to 4.3 and 3 to 3.7 log CFU/g decrease in the microbial population in comparison with the untreated group, respectively. At the end of refrigerated storage time, the chemical change in all treated fillets was significantly lower than the untreated group (P < 0.05). The treatments of frozen trout fillets with SA + different concentrations of PFE and CCM resulted in better microbial and chemical properties than of the untreated group at the end of storage period (P < 0.05).Practical ApplicationAntimicrobial edible coatings from natural renewable resources have been found to be very useful in the food preservation field owing to the increasing consumer interest for the improvement of shelf‐life property and appearance of fresh foodstuffs. Rainbow trout fillets without chemical preservatives have a limited shelf‐life due to its biological properties. This study indicates the possibility of application of sodium alginate coatings containing Prosopis farcta extract and curcumin nanoparticles to increase shelf‐life and maintain the quality of refrigerated trout fillets.
Impact of Climate and Land Use Change on Streamflow and Sediment Yield in a Snow‐Dominated Semiarid Mountainous Watershed
Authors: Khatri K.B. , Strong C. , von Stackelberg N. , Buchert M. , Kochanski A.K. 
Published: November 2019

AbstractThis study investigates the impact of climate and land use change on the magnitude and timing of streamflow and sediment yield in a snow‐dominated mountainous watershed in Salt Lake County, Utah using a scenario approach and the Hydrological Simulation Program — FORTRAN model for the 2040s (year 2035–2044) and 2090s (year 2085–2094). The climate scenarios were statistically and dynamically downscaled from global climate models. Land use and land cover (LULC) changes were estimated in two ways — from a regional planning scenario and from a deterministic model. Results indicate the mean daily streamflow in the Jordan River watershed will increase by an amount ranging from 11.2% to 14.5% in the 2040s and from 6.8% to 15.3% in the 2090s. The respective increases in sediment load in the 2040s and 2090s is projected to be 6.7% and 39.7% in the canyons and about 7.4% to 14.2% in the Jordan valley. The historical 50th percentile timing of streamflow and sediment load is projected to be shifted earlier by three to four weeks by mid‐century and four to eight weeks by late‐century. The projected streamflow and sediment load results establish a nonlinear relationship with each other and are highly sensitive to projected climate change. The predicted changes in streamflow and sediment yield will have implications for water supply, flood control and stormwater management.
Positive HLA‐B27 and sacroiliitis is not always spondyloarthritis
Authors: Aslam Fawad , Chivers Frederick Spencer , Doshi Krupa B. , Chang‐Miller April 
Published: November 2019

AbstractA 36‐year‐old man was treated for several years with multiple agents for ankylosing spondylitis based on positive human leukocyte antigen‐B27 and sacroiliitis. He was also diagnosed with osteoporosis and hypophosphatemia. Over these years, from being an avid runner, he became dependent on a walker for ambulation. The lack of treatment response and the low phosphorus were clues that eventually led to a diagnosis of tumor‐induced osteomalacia. This case discusses the importance of not solely relying on genetic markers and sacroiliitis for diagnosing ankylosing spondylitis as other conditions can cause similar presentations.
A Novel Mouse Model of Acute‐on‐Chronic Cholestatic Alcoholic Liver Disease: A Systems Biology Comparison With Human Alcoholic Hepatitis
Authors: Furuya Shinji , Argemi Josepmaria , Uehara Takeki , Katou Yuuki , Fouts Derrick E. , Schnabl Bernd , Dubuquoy Laurent , Belorkar Abha , Vadigepalli Rajanikanth , Kono Hiroshi , Bataller Ramon , Rusyn Ivan 
Published: November 2019

BackgroundAlcohol‐related liver disease is the main cause of liver‐related mortality worldwide. The development of novel targeted therapies for patients with advanced forms (i.e., alcoholic hepatitis, AH) is hampered by the lack of suitable animal models. Here, we developed a novel mouse model of acute‐on‐chronic alcohol liver injury with cholestasis and fibrosis and performed an extensive molecular comparative analysis with human AH.MethodsFor the mouse model of acute‐on‐chronic liver injury, we used 3,5‐diethoxycarbonyl‐1,4‐dihydrocollidine (DDC, 0.05% w/w) diet for 8 weeks to establish cholestatic liver fibrosis. After 1‐week washout period, male mice were fed intragastrically for 4 weeks with up to 24 g/kg of ethyl alcohol in a high‐fat diet. This animal model was phenotyped using histopathology, clinical chemistry, microbiome, and gene expression approaches. Data were compared to the phenotypes of human alcohol‐related liver disease, including AH.ResultsMice with cholestatic liver fibrosis and subsequent alcohol exposure (DDC + EtOH) exhibited exacerbated liver fibrosis with a pericellular pattern, increased neutrophil infiltration, and ductular proliferation, all characteristics of human AH. DDC administration had no effect on urine alcohol concentration or liver steatosis. Importantly, DDC‐ and alcohol‐treated mice showed a transcriptomic signature that resembled that of patients with AH. Finally, we show that mice in the DDC + EtOH group had an increased gut barrier dysfunction, mimicking an important pathophysiological mechanism of human AH.ConclusionsWe developed a novel mouse model of acute‐on‐chronic cholestatic alcoholic liver injury that has considerable translational potential and can be used to test novel therapeutic modalities for AH.
The ability of deferred tax to predict future tax
Authors: Mear Kim , Bradbury Michael , Hooks Jill 
Published: November 2019

AbstractWe examine the usefulness of tax allocation accounting (deferred tax) for predicting future tax paid and future tax expense. Deferred taxes increase the explanatory power (R2) of regression models where future taxes paid or future tax expense is the dependent variable. However, the mean out‐of‐sample forecast errors for tax paid (future tax expense) is 30 (45.5) percent. Deferred tax increases predictive ability on pooled data, but is inconsistent on a year‐by‐year basis. We examine three explanations for poor predictive ability: losses, tax changes and asset growth. We discuss the policy and practical implications of our findings.
Computed tomographic morphometry of the biceps brachii muscle tendon of dogs affected by the medial coronoid disease
Authors: Veksins Armands , Kozinda Oskars , Sandersen Charlotte 
Published: November 2019

AbstractThe objective of this study was to measure the biceps brachii muscle (BBM) attachment to the medial coronoid process (MCP) using computed tomography images and to compare these data between clinically healthy and dogs affected by medial coronoid disease (MCD). Computed tomography was performed in MCD‐affected and healthy dogs. Multiplanar reconstruction views were obtained to measure distance (cm) of the BBM attachment point to the MCP. Results showed that the mean BBM attachment point‐to‐MCP was 1.42 ± 0.23 cm in MCD‐affected and 1.27 ± 0.20 cm in healthy dogs, respectively. In dogs with MCD, the BBM attachment point‐to‐MCP was significantly more abaxial than in clinically healthy dogs (p < .001). The results of this study support the hypothesis that the BBM attachment site is more abaxial to the MCP and therefore may contribute to supraphysiological overload leading to MCD. Albeit more research is necessary, this study proves a relationship between the BBM attachment point and the development of MCD.
Institutional preparedness to prevent and manage anaesthesia‐related ‘can't intubate, can't oxygenate’ events in Australian and New Zealand teaching hospitals
Authors: Rehak A. , Watterson L. M. 
Published: November 2019

SummaryIt is unclear how the recent local and international focus on systems issues and human factors in ‘can't intubate, can't oxygenate’ events has impacted institutional preparedness in Australia and New Zealand. This study attempts to capture a snapshot of current practices in Australian and New Zealand teaching hospitals with regard to preparedness to prevent and manage ‘can't intubate, can't oxygenate’ events. All Australian and New Zealand College of Anaesthetists’ teaching hospitals were invited to complete an online survey consisting of 33 questions on terminology, equipment, cognitive aids, training and quality assurance. Follow‐up was by both email and telephone. Responses were received from 129 (91%) of the 142 sites. The survey revealed both countries have largely moved to point‐of‐care ‘can't intubate, can't oxygenate’ equipment. There were regional differences reported, with Australia favouring equipment, cognitive aids and teaching that supports a combined cannula and scalpel approach to ‘can't intubate, can't oxygenate’, whilst New Zealand favours those promoting a scalpel‐only approach. A lack of consistency with the terminology used around ‘can't intubate, can't oxygenate’ both within and between the two countries was also identified. This survey has revealed a generally reassuringly high degree of institutional preparedness to prevent and manage ‘can't intubate, can't oxygenate’ events across both countries but with strong regional differences in approaches. Little is known of the institutional practices outside these countries, making international comparison difficult.
Low physical activity and high sedentary behaviour are associated with adolescents’ suicidal vulnerability: Evidence from 52 low‐ and middle‐income countries
Authors: Uddin Riaz , Burton Nicola W. , Maple Myfanwy , Khan Shanchita R. , Tremblay Mark S. , Khan Asaduzzaman 
Published: November 2019

AbstractAimTo examine the relationships of physical activity (PA) and sedentary behaviour (SB) with suicidal thoughts and behaviour among adolescents in low‐ and middle‐income countries (LMICs).MethodsGlobal School‐based Student Health Survey data from 206 357 students (14.6 ± 1.18 years; 51% female) in 52 LMICs were used. Students reported on suicidal ideation, suicide planning, suicide attempts, PA, leisure‐time SB and socio‐demographic characteristics. Multilevel mixed‐effects generalised linear modelling was used to examine the associations.ResultsHigh leisure‐time SB (≥3 hours/day) was independently associated with higher odds of suicidal ideation, suicide planning and suicide attempts for both male and female adolescents. Insufficient PA (<60 mins/day) was not associated with higher odds of ideation for either sex; however, it was associated with planning and attempts for male adolescents. The combination of insufficient PA and high SB, compared with sufficient PA and low SB, was associated with higher odds of suicidal ideation and suicide planning for both male and female adolescents, and suicide attempts for male adolescents.ConclusionHigh SB may be an indicator of suicidal vulnerability among adolescents in LMICs. Low PA may be a more important risk for suicidal thoughts and behaviours among male, than female, adolescents. Promoting active lifestyle should be integrated into suicide prevention programmes in resource‐poor settings.
Editorial: how safe is it to administer the BCG vaccination to babies exposed to anti‐TNFα medications antenatally?
Authors: Bouri Sonia , Hart Ailsa L. 
Published: November 2019

LINKED CONTENTThis article is linked to Luu et al papers. To view these articles, visit https://doi.org/10.1111/apt.15504 and https://doi.org/10.1111/apt.15559.
Editorial: effect of exercise on physical frailty in patients with chronic liver disease. Authors' reply
Authors: Armstrong Matthew J. , Williams Felicity R. , Johnson Jill , Freer Alice 
Published: November 2019

LINKED CONTENTThis article is linked to Williams et al and Ravikiran and Bhat papers. To view these articles, visit https://doi.org/10.1111/apt.15491 and https://doi.org/10.1111/apt.15534.
Editorial: how safe is it to administer the BCG vaccination to babies exposed to anti‐TNFα medications antenatally? Authors' reply
Authors: Luu Maxime , Benzenine Eric , Barkun Alan , Doret Muriel , Michiels Christophe , Degand Thibault , Quantin Catherine , Bardou Marc 
Published: November 2019

LINKED CONTENTThis article is linked to Luu et al and Bouri and Hart papers. To view these articles, visit https://doi.org/10.1111/apt.15504 and https://doi.org/10.1111/apt.15535.
Sequential mutational evaluation of CALR ‐mutated myeloproliferative neoplasms with thrombocytosis reveals an association between CALR allele burden evolution and disease progression
Authors: Cottin Laurane , Riou Jérémie , Orvain Corentin , Ianotto Jean Christophe , Boyer Françoise , Renard Maxime , Truchan‐Graczyk Matgorzata , Murati Anne , Jouanneau‐Courville Rébecca , Allangba Olivier , Mansier Olivier , Burroni Barbara , Rousselet Marie-Christine , Quintin‐Roué Isabelle , Martin Antoine , Sadot‐Lebouvier Sophie , Delneste Yves , Chrétien Jean‐Marie , Hunault‐Berger Mathilde , Blanchet Odile , Lippert Eric , Ugo Valérie , Luque Paz Damien 
Published: November 2019

SummaryIn myeloproliferative neoplasms (MPN), JAK2V617F allele burden measurement has an impact on prognosis that helps in patient monitoring. Less is known about its usefulness in CALR‐mutated cases. Additional mutations found by next‐generation sequencing have also shown an impact on prognosis that may drive therapeutic choices, especially in myelofibrosis, but few studies focused on CALR‐mutated patients. We performed a molecular evaluation combining next‐generation sequencing with a myeloid panel and CALR allele burden measurement at diagnosis and during follow‐up in a cohort of 45 patients with CALR‐mutated essential thrombocythaemia. The bone marrow histology was also blindly reviewed in order to apply the WHO2016 classification. The most frequently mutated gene was TET2 (11/21 mutations). CALR type 1‐like patients appear to have a more complex molecular landscape. We found an association between disease progression and CALR allele burden increase during follow‐up, independently of additional mutations and WHO2016‐reviewed diagnosis. Patients with disease progression at the time of follow‐up showed a significant increase in CALR allele burden (+16·7%, P = 0·005) whereas patients without disease progression had a stable allele burden (+3·7%, P = 0·194). This result argues for clinical interest in CALR allele burden monitoring.