bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eliminating Hydrogen Peroxide Volatiles after Lead White Conversion Treatment Via Sorption Agents
Authors: Raab Luise , Henniges Ute , Brückle Irene 
Published: May 2020

AbstractHydrogen peroxide (HP) residues that remain after the conversion of blackened lead white may cause unwanted paper discolouration and degradation. Four VOCs sorption materials were tested for their ability to eliminate HP gas evolving from the treated substrate. This was tested by measuring the change in HP concentration in aqueous solution and in an enclosed air space in the presence of MicroChamber® Interleaving Paper, Corrosion Intercept® film, Zorflex® activated carbon cloth (ACC) and iron sulphate-impregnated paper. Detection with the colour indicator Quantofix® test strips and a Dräger X-am® 5100 single gas detection device showed that ACC is by far most efficient in decreasing the HP concentration. ACC was also effective in preventing paper discolouration in test objects that had been HP-treated for lead white conversion and then were stored sandwiched between ACC. Although ACC may not eliminate all HP from the substrate, it can diminish its negative effects on the treated object and protect other objects in the vicinity.
„Da hatte ich einfach kein Interesse mehr daran.“ Analyse der Verläufe von Vereinsmitgliedschaftskarrieren jugendlicher Fußballer unter besonderer Berücksichtigung des Dropouts
Authors: Löbig Anna , Ehnold Peter , Schlesinger Torsten 
Published: May 2020

ZusammenfassungAusgehend von erhöhten Dropout-Quoten, welche mit negativen Konsequenzen für Verbände, Vereine oder Mitglieder einhergehen können, steht die Analyse typischer Vereinskarrieren jugendlicher Fußballer unter besonderer Berücksichtigung des Dropouts im Fokus des Beitrags. Ergänzend zu bisherigen, meist querschnittlich angelegten Studien wird dabei eine lebenslaufbezogene Perspektive eingenommen. Jugendliche Fußballer (n=15) aus verschiedenen Vereinen (n=4) wurden mit Hilfe des biografischen Mappings befragt. Dabei zeigen sich typische Verläufe in Abhängigkeit von der subjektiven Relevanz des Vereinswechsels (Vereins-Dropout) sowie des Fußball-Dropouts: „Vereins-Dropouts mit stabiler Fußballmitgliedschaft“ (Typ 1), „Plötzliche Fußball-Dropouts mit oder ohne vorherige Vereinswechsel“ (Typ 2), „Temporäre Fußball-Dropouts mit anschließendem Vereinswechsel“ (Typ 3) und „Instabile Fußballmitgliedschaftskarrieren“ (Typ 4). Diese Verlaufstypologien erweitern die bis-herige Befundlage um eine prozessuale/verlaufsbezogene Perspektive und eröffnen dadurch alternative Steuerungsoptionen im Umgang mit Dropouts.
Rupture Characteristics and Bedrock Structural Control of the 2016 Mw 6.0 Intraplate Earthquake in the Petermann Ranges, Australia
Authors: Attanayake Januka , King Tamarah R. , Quigley Mark C. , Gibson Gary , Clark Dan , Jones Abraham , Brennand Sarah L. , Sandiford Mike 
Published: May 2020

ABSTRACT
The 20 May 2016 surface-rupturing intraplate earthquake in the Petermann Ranges is the largest onshore earthquake to occur in the Australian continent in 19 yr. We use in situ and Interferometric Synthetic Aperture Radar surface observations, aftershock distribution, and the fitting of P-wave source spectra to determine source properties of the Petermann earthquake. Surface observations reveal a 21-km-long surface rupture trace (strike=294°±29°) with heterogeneous vertical displacements (&lt;0.1–0.96  m). Aftershock arrays suggest a triangular-shaped rupture plane (dip  ≈  30°) that intersects the subsurface projection of the major geophysical structure (Woodroffe thrust [WT]) proximal to the preferred location of the mainshock hypocenter, suggesting the mainshock nucleated at a fault junction. Footwall seismicity includes apparent southwest-dipping Riedel-type alignments, including possible activation of the deep segment of the WT. We estimate a moment magnitude (Mw) of 6.0 and a corner frequency (fc) of 0.2 Hz, respectively, from spectral fitting of source spectra in the 0.02–2 Hz frequency band. These translate into a fault area of 124  km2 and an average slip of 0.36 m. The estimated stress drop of 2.2 MPa is low for an intraplate earthquake; we attribute this to low-frictional slip (effective coefficient of friction &gt;0.015) along rupture-parallel phyllosilicate-rich surfaces within the host rock fabric with possible additional contributions from elevated pore-fluid pressures.
Pesquisas em recursos de alta tecnologia para comunicação e transtorno do espectro autista
Authors: Schirmer Carolina Rizzotto 
Published: May 2020

Cerca de um terço dos indivíduos diagnosticados com Transtorno do Espectro Autista (TEA) não conseguem desenvolver a oralidade. Os benefícios da Comunicação Alternativa (CA) para pessoas com TEA são bem reconhecidos e podem ser usados ​​para ampliar a fala limitada ou atuar como o método de comunicação principal (ou seja, alternativo). Os dispositivos de geração de fala referem-se a uma variedade de soluções de alta tecnologia, incluindo dispositivos de comunicação eletrônica dedicados (comunicadores/vocalizadores), processadores de texto com voz sintetizada e dispositivos móveis multifuncionais (ex. iPad, iPod e tablets com sistema Android) carregados com aplicativos de CA, e que são um opções viáveis para indivíduos com autismo. O objetivo deste artigo é verificar os estudos que investigam a alta tecnologia para comunicação e TEA, publicados no Augmentative and Alternative Communication Journal, que é o periodico oficial da Sociedade Internacional de Comunicação Aumentativa e Alternativa (ISAAC), no período de 2011 a 2018. Esta é uma área nova de conhecimento que está em rápido crescimento e com poucos estudos no Brasil. Os resultados dos 15 artigos analisados indicam que pessoas com TEA se beneficiam com o uso da alta tecnologia. Pesquisas futuras em criação de recursos de comunicação, intervenção com usuários e descrição dos repertórios verbais são recomendadas.
Moderate Intensity of Physical Exercise increased Β (Beta) Cell and Size of Langerhans Islets in Streptozotocin Induced Diabetes Mellitus Rats
Authors: Nurdin Sarah M , Nugraheni Nuniek , Wulan Mei 
Published: May 2020

Background: The death of β cells Langerhans islets in Diabetes Mellitus (DM) can cause loss of Langerhans islet function and worsen the progression of DM. Physical exercise plays a major part in DM treatment.Aim: to observe the effect of moderate intensity exercise to β (beta) cell numbers and Langerhans islets area size in Streptozotocin (STZ) induced diabetes in rats.Methods: Thirty adult male Wistar rats (Rattusnorvegicus) divided into 3, Group 1 as the control, Group 2 received 35 mg/kg streptozotocin induction treatment, Group 3 received 35 mg/kg streptozotocin induction and physical exercise, swimming, with moderate intensity 70% from the swimming maximal ability, 9% of body weight load, 4 times a week for 4 weeks. Datas collected were in the form of histopathology slide of pancreatic tissue after receiving treatment for 28 days.Results: There are significant differences of β-cell pancreas number between group K1 and K2 (p<0,001), group K2 and to K3 (p<0,001). No significant difference between group K1 and K3 (p=0,102). The Langerhans islets area sizes of pancreas tissue between group K1, K2, and K3 are significantly different (p<0,001).Conclusion: This study shows moderate-intensity physical exercise can increase the number of β cell and average area size of Langerhans islets. The effect of physical exercise depends on the intensity of exercise and the capacity of pancreatic function left of the diabetic.
Genetic diversity and different cross-neutralization capability of porcine circovirus type 2 isolates recently circulating in South Korea
Authors: Kang Seok-Jin , Kang Hyeonjeong , Yu Su-Hwa , Lee Hye Jeong , Lee Nakhyung , Hyun Bang-Hun , Cha Sang-Ho 
Published: May 2020

Abstract
Background: Porcine circovirus type 2 (PCV2) is a small single-stranded DNA virus and a primary cause of PCV-associated diseases (PCVAD) that result in substantial economic loss for swine farms. Between 2016 and 2018, PCV2 field viruses were isolated from PCVAD-affected swine farms in South Korea and investigated for genetic and antigenic heterogeneity. Results: The genetic analysis of ORF2 showed that the genotype of the Korean PCV2 field isolates has been rapidly shifted from PCV2a or 2b to mutant PCV2b known as PCV2d with 82.6% to 100% amino acid sequence similarity. PCV2-specific monoclonal antibodies (mAbs) demonstrated variable antigen-binding activity to four representative Korean PCV2 field isolates [QIA215 (PCV2a), QIA418 (PCV2b), QIA169 (PCV2d), and QIA244 (PCV2d)] without genotype specificity, and one mAb showed neutralization activity to QIA215. In a cross-virus neutralization assay using anti-PCV2 sera of pigs and guinea pigs injected with a commercial vaccine and the Korean PCV2 field isolates, the anti-porcine sera of a commercial vaccine had high neutralization activity against QIA215 and QIA418 with statistically lower activity against PCV2d viruses. Anti-guinea pig sera of QIA215, QIA418, QIA169, and a commercial vaccine had high neutralization activity against all of the viruses with significantly lower activity against QIA244. Importantly, anti-guinea pig sera of QIA244 had high neutralization activity against all of the viruses. Conclusions: This study confirmed genetic and antigenic diversity among recent PCV2 field isolates in Korean swine farms, and the strain-based difference in virus neutralization capability should be considered for more effective control by vaccination.
Comparative Efficacy of Neuraxial and General anesthesia for hip fracture surgery: A meta-analysis of randomized clinical trials
Authors: Zheng Xinxun , Tang Yuming , Gao Yuan , Liu Zhiheng 
Published: May 2020

Abstract
Background: The choice of anesthesia technique remains debatable in patients undergoing surgical repair of hip fracture. This meta-analysis was performed to compare the effect of neuraxial (epidural/spinal) versus general anesthesia on perioperative outcomes in patients undergoing hip fracture surgery.Methods: Medline, Cochrane Library, Science-Direct, and EMBASE databases were searched to identify eligible studies focused on the comparison between neuraxial and general anesthesia in hip fracture patients between January 2000 and May 2019. Perioperative outcomes were extracted for systemic analysis. The sensitivity analyses were conducted using a Bonferroni correction and the leave-one-out method. The evidence quality for each outcome was evaluated by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system.Results: Nine randomized controlled trials (RCTs) including 1084 patients fulfilled our selection criteria. The outcomes for the meta-analysis showed that there were no significant differences in the 30-day mortality (OR = 1.34, 95% CI 0.56, 3.21; P = 0.51), length of stay (MD = -0.65, 95% CI -0.32, 0.02; P =0.06), and the prevalence of delirium (OR = 1.05, 95% CI 0.27, 4.00; P = 0.95), acute myocardial infarction (OR = 0.88, 95% CI 0.17, 4.65; P = 0.88), deep venous thrombosis (OR = 0.48, 95% CI 0.09, 2.72; P = 0.41), and pneumonia (OR = 1.04, 95% CI 0.23, 4.61; P = 0.96) for neuraxial anesthesia compared to general anesthesia, and there was a significant difference in blood loss between the two groups (MD = -137.8, 95% CI -241.49, -34.12; p = 0.009). However, after applying the Bonferroni correction for multiple testing, all the adjusted p-values were above the significant threshold of 0.05. The evidence quality for each outcome evaluated by the GRADE system was low.Conclusions: In summary, our present study demonstrated that there might be a difference in blood loss between patients receiving neuraxial and general anaesthesia, however, this analysis was not robust to adjustment for multiple testing and therefore at high risk for a type I error. Due to small sample size and enormous inconsistency in the choice of outcome measures, more high-quality studies with large sample size are needed to clarify this issue.
FBXL6 governs c-MYC to promote hepatocellular carcinoma through ubiquitination and stabilization of HSP90AA1
Authors: Shi Weidong , Feng Lanyun , Dong Shu , Ning Zhouyu , Hua Yongqiang , Liu Luming , Chen Zhen , Meng Zhiqiang 
Published: May 2020

Abstract
BACKGROUND: Heat shot protein 90 (HSP90) AA1 functions as an onco-protein to regulate the assembly, manipulation, folding and degradation of its client proteins, including c-MYC. However, little is known about the mechanism of HSP90AA1 regulation.METHODS: Transcriptome RNA-sequencing data of hepatocellular carcinoma (HCC) samples were used to detect the mRNA expression of FBXL6. Immunoprecipitation/Mass Spectrum (IP/MS) method was used to identify the interacting proteins of FBXL6. The co-immunoprecipitation assay was used to determine the interaction between FBXL6 and HSP90AA1. The in vivo ubiquitination assay was performed to determine the regulation of HSP90AA1 by FBXL6. Luciferase reporter and chromatin immunoprecipitation (ChIP) assays were used to determine the transcriptional regulation of FBXL6 by c-MYC. Immunohistochemical (IHC) staining was performed to study the correlation of FBXL6 and HSP90AA1 protein expression in 87 HCC samples. Cell counting and colony formation assays were implemented to detect the biological effects of FBXL6 on the growth of HCC cells in vitro. The effect of FBXL6 on HCC tumor growth in vivo was studied in a tumor xenograft model in mice. RESULTS: Here, we identified the orphan F-box protein FBXL6, a substrate recognition subunit of an SCF (Skp1-Cul1-F-box protein) complex, as the ubiquitin ligase for HSP90AA1. FBXL6 promoted K63-dependent ubiquitination of HSP90AA1 to stabilize it. Through analysis of the TCGA dataset, we found that FBXL6 was significantly increased in HCC tissues and positively correlated with c-MYC pathway. FBXL6 accumulation in HCC causes the stabilization and activation of c-MYC by preventing HSP90AA1 degradation. The activated c-MYC directly binds to the promoter region of FBXL6 to induce its mRNA expression.CONCLUSION: Collectively, our data revealed an unknown FBXL6-HSP90AA1-c-MYC axis which might contribute to the oncogenesis of HCC, and we propose that inhibition of FBXL6 might represent an effective therapeutic strategy for HCC treatment.
Prevalence and risk factors for bone loss in Southern Chinese with rheumatic diseases
Authors: Hu Zhuoran , Xu Shuiming , Yang Qingyuan , Qi Jun , Lin He , Ni Weifeng , Du Keqian , Gu Jieruo , Lin Zhiming 
Published: May 2020

Abstract
Objectives: This study is to explore the prevalence of different stages of bone loss and the potential risk factors in rheumatic patients.Method: A cross-sectional study recruits 1,398 rheumatic patients and 302 healthy subjects. Demographic data, blood, and bone mineral density (BMD) tests are collected. Risk factors for bone loss in rheumatic patients are analyzed by logistic regression.Results: (1) Rheumatic patients are consisted of 40.0% rheumatoid arthritis (RA), 14.7% systemic lupus erythematosus (SLE), 14.2% osteoarthritis (OA), 9.2% ankylosing spondylosis (AS), 7.9% gout, 7.0% primary Sjogren syndrome (pSS), 3.8% systemic sclerosis (SSc), and 3.2% mixed connective tissue disease (MCTD). (2) In male patients aged under 50 and premenopausal female patients, the bone mineral density score of AS (53.9%, P<0.001) and SLE (39.6%, P=0.034) patients is lower than the healthy controls (18.2%). (3) Osteopenia and osteoporosis are more prevailing in male patients aged or older than 50 and postmenopausal female patients with RA (P<0.001), OA (P=0.02) and SLE (P =0.011) than healthy counterparts. (4) Those with SLE, RA and AS gain the highest odd ratio of ‘score below the expected range for age’, osteopenia and osteoporosis, respectively. (5) Age, female, low BMI and hypovitaminosis D are found negatively associated with bone loss. Dyslipidemia and hyperuricemia could be protective factors.Conclusion: Young patients with AS and SLE have a significant higher occurrence of bone loss, and older patients with RA, OA and SLE had higher prevalence than healthy counterparts. SLE, RA, SSc and AS were founded significant higher risks to develop into bone loss after adjustment. Age, BMI and gender were commonly-associated with bone loss in all age-stratified rheumatic patients. These findings were not markedly different from those of previous studies.
Distribution and phylogenetic diversity of Anopheles species in malaria endemic areas of Honduras in an elimination setting
Authors: Escobar Denis , Ascencio Krisnaya , Ortiz Andrés , Palma Adalid , Fontecha Gustavo 
Published: May 2020

Abstract
Background : Anopheles mosquitoes are the vectors of malaria, one of the most important infectious diseases in the tropics. More than 500 Anopheles species have been described worldwide, and more than 30 are considered a public health problem. In Honduras, information on the distribution of Anopheles spp. and its genetic diversity is scarce. This study aimed to describe the distribution and genetic diversity of Anopheles mosquitoes in Honduras. Methods : Mosquitoes were captured in 8 locations in 5 malaria endemic departments during 2019. Two collectionmethods were used. Adult anophelines were captured outdoors using CDC light traps and by aspiration of mosquitoes at rest. The morphological identification was performed using taxonomic keys. Genetic analyses included the sequencing of a partial region of the cytochrome oxidase I gene (COI) and the ribosomal internal transcribed spacer 2 (ITS2). Results : A total of 1320 anophelines were collected and identified through morphological keys. Seven Anopheles species were identified. Anopheles albimanus was the most widespread and abundant species (74.02%). To confirm the morphological identification of the specimens, 175 and 122 sequences were obtained for COI and ITS2 respectively. Both markers confirmed the morphological identification. COI showed a greater nucleotide diversity than ITS2 in all species. High genetic diversity was observed within the populations of An. albimanus while An. darlingi proved to be a highly homogeneous population. Phylogenetic analyses revealed clustering patterns in An. darlingi and An. neivai in relation to specimens from South America. New sequences for An. crucians , An. vestitipennis , and An. neivai are reported in this study. Conclusions : Here we report the distribution and genetic diversity of Anopheles species in endemic areas of malaria transmission in Honduras. According to our results, both taxonomic and molecular approaches are useful tools in the identification of anopheline mosquitoes. However, both molecular markers differ in their ability to detect intraspecific genetic diversity. These results provide supporting data for a better understanding of the distribution of malaria vectors in Honduras.
Social, economic, and legislative factors and global road traffic fatalities
Authors: Haghighi Mohammad Reza Rahmanian , Sayari Mohammad , Ghahramani Sulmaz , Lankarani Kamran Bagheri 
Published: May 2020

Abstract
Abstract
Background: Road traffic fatalities (RTF) is the 8th cause of mortality around the world. At the end of the Decade of Action, it would be of utmost importance to revisit our knowledge on the determinants of RTF.
Methods: We used road safety development index which accounts for the interactions between system, human and products to assess the RTF in 115 and 113 countries in 2013 and 2016, respectively. To analyze data, three statistical procedures (linear regression, classification and regression trees, and multivariate adaptive regression splines) were employed.
Results: Classification and regression trees has the best performance amongst all others followed by multivariate adaptive regression splines for 2013 and 2016 data set with an R 2 around 0.83. Results show that any increase in human development index was associated with RTF reduction. Comparing RTF data of 2013 and 2016, 8 countries experienced a change of more than 30%, which demonstrated a significant relationship with GINI index (named after Corrado Gini). Considering the three components of human development index, it is revealed that education explained most of RTF variation in classification and regression trees model followed by income and life expectancy.
Conclusion: Policymakers should consider road traffic accidents as a socio-economic issue. In this regard, they can make provisions to reduce RTF in the long run by focusing on enhancing the three components of human development index, mainly education. However, there is a need to investigate the correlation among these three components with RTF with different time-trend procedures.
Examining the quality of record linkage process using nationwide Brazilian administrative databases to build a large birth cohort
Authors: Almeida Daniela , Gorender David , Ichihara Maria Yury , Sena Samila , Menezes Luan , Barbosa George C. G. , Fiaccone Rosimeire L. , Paixao Enny , Pita Robespierre , Barreto Mauricio L. 
Published: May 2020

Abstract
Background : Research using linked routine population-based data collected for non-research purposes has increased in recent years because they are a rich and detailed source of information. The objective of this study is to present an approach to prepare and link data from administrative sources in a middle-income country, to estimate its accuracy and to identify potential sources of bias by comparing linked and no-linked case. Methods: We linked two administrative datasets with data covering the period 2001 to 2015, using maternal attributes (name, age, date of birth, and municipally of residence) from Brazil: live birth information system and the 100 Million Brazilian Cohort (created using administrative records from over 114 million individuals whose families applied for social assistance via the National Register for Social Programmes) implementing an in house developed linkage tool CIDACS-RL. We then estimated the accuracy of the linkage and examined the characteristics of missed-matches to identify any potential source of bias. Results : A total of 27,699,891 live births linked with maternal information recorded in the baseline of the 100 Million Brazilian Cohort dataset of those, 16,447,414 (59.4%) children were found registered in the 100 Million Brazilian Cohort dataset. The sensitivity of the linkage ranged from 39.3% in 2001 to 82.1% in 2014. A substantial improvement in the linkage sensitivity after the introduction of maternal date of birth attribute, in 2011, was observed. Our analyses indicated a slightly higher proportion of missing data among missed matches and a higher proportion of people living in an urban area and self-declared as Caucasian among linked pairs when compared with non-linked sets. Discussion : We demonstrated that CIDACS-RL is capable of performing high quality and accurate linkage even with a limited number of common attributes, using indexation as a blocking strategy in large routine databases from a middle-income country. However, residual records occurred more among people under worse living conditions. The results presented in this study reinforce the need of evaluating linkage quality and when necessary to take linkage error into account for the analyses of any generated dataset.