bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green-banana biomass consumption by diabetic patients improves plasma low-density lipoprotein particle functionality
Authors: Lotfollahi Zahra , Mello Ana Paula de Queiroz , Costa Edna S. , Oliveira Cristiano L. P. , Damasceno Nagila R. T. , Izar Maria Cristina , Neto Antonio Martins Figueiredo 
Published: July 2020

AbstractThe aim of this study was to investigate the effects of 6-months consumption of green-banana biomass on the LDL particle functionality in subjects with type 2 diabetes. Subjects (n = 39, mean age 65 years old) of both sexes with diabetes (HbA1c ≥ 6·5%) were randomized to receive nutritional support plus green-banana biomass (40 g) (n = 21) or diet alone (n = 18) for 6-months. Non-linear optical responses of LDL solutions from these participants were studied by Z-scan technique. UV–visible spectrophotometer was used to measure the absorbance of the LDL samples. Small Angle X-ray Scattering and Dynamic Light Scattering experiments were used to look for any structural changes in LDL samples and to determine their size distribution. The Lipoprint test was used to determine the LDL sub-fractions in terms of distribution and size. Consumption of green-banana biomass, reduced total- (p = 0.010), non-HDL-cholesterol (p = 0.043), glucose (p = 0.028) and HbA1c (p = 0.0007), and also improved the protection of the LDL particle against oxidation, by the increase in carotenoids content in the particles (p = 0.007). This higher protection against modifications may decrease the risk of developing cardiovascular disease. These benefits of the green-banana biomass encourage the use of resistant starches with potential clinical applications in individuals with pre-diabetes and diabetes.
Carbon steel corrosion by bacteria from failed seal rings at an offshore facility
Authors: Salgar-Chaparro Silvia J. , Darwin Adam , Kaksonen Anna H. , Machuca Laura L. 
Published: July 2020

AbstractCorrosion of carbon steel by microorganisms recovered from corroded seal rings at an offshore floating production facility was investigated. Microbial diversity profiling revealed that communities in all sampled seal rings were dominated by Pseudomonas genus. Nine bacterial species, Pseudomonas aeruginosa CCC-IOB1, Pseudomonas balearica CCC-IOB3, Pseudomonas stutzeri CCC-IOB10, Citrobacter youngae CCC-IOB9, Petrotoga mobilis CCC-SPP15, Enterobacter roggenkampii CCC-SPP14, Enterobacter cloacae CCC-APB1, Cronobacter sakazakii CCC-APB3, and Shewanella chilikensis CCC-APB5 were isolated from corrosion products and identified based on 16S rRNA gene sequence. Corrosion rates induced by the individual isolates were evaluated in artificial seawater using short term immersion experiments at 40 °C under anaerobic conditions. P. balearica, E. roggenkampii, and S. chilikensis, which have not been associated with microbiologically influenced corrosion before, were further investigated at longer exposure times to better understand their effects on corrosion of carbon steel, using a combination of microbiological and surface analysis techniques. The results demonstrated that all bacterial isolates triggered general and localised corrosion of carbon steel. Differences observed in the surface deterioration pattern by the different bacterial isolates indicated variations in the corrosion reactions and mechanisms promoted by each isolate.
Targeting the PLK1-FOXO1 pathway as a novel therapeutic approach for treating advanced prostate cancer
Authors: Gheghiani Lilia , Shang Shengzhe , Fu Zheng 
Published: July 2020

AbstractThe forkhead box protein O1 (FOXO1) is considered to be a key tumor suppressor due to its involvement in a broad range of cancer-related functions, including cellular differentiation, apoptosis, cell cycle arrest, and DNA damage. Given that inactivation of FOXO1 has been reported in many types of human cancer, we sought to investigate whether restoration of the pro-apoptotic activity of FOXO1 may be used as a new promising strategy for cancer treatment. Our previous study revealed that Polo-like kinase 1 (PLK1), a serine/threonine kinase that is essential for cell cycle progression, is a novel and major regulator of FOXO1 in the late phases of the cell cycle. Here, we provided evidence that PLK1-dependent phosphorylation of FOXO1 induces its nuclear exclusion and negatively regulates FOXO1′s transcriptional activity in prostate cancer (PCa). Blocking the PLK1-dependant phosphorylation of FOXO1 restored the pro-apoptotic function of FOXO1 in PCa. Combining PLK1 inhibition with nocodazole (to induce mitotic arrest) had synergistic antitumor effects in vitro, with minimal effect on normal prostate epithelial cells. These findings shed light on a novel approach to reactivate apoptotic pathways in advanced PCa and support targeting PLK1-FOXO1 pathways as a novel approach for treating advanced PCa.
Prevalence of neck/shoulder pain among public hospital workers in China and its associated factors: a cross-sectional study
Authors: Dong Hongyun , Zhang Qiong , Liu Guangzeng , Shao Tingguo 
Published: July 2020

AbstractStudies have reported that neck and/or shoulder pain (NSP) was prevalent and a non-ignorable occupational health problem in healthcare providers. Considering data deficiency on NSP, we aimed to investigate the prevalence and sick leave absence of NSP among public hospital workers in Shandong, China and to explore the associated factors for chronic NSP. A self-administered questionnaire including the Dutch Musculoskeletal Questionnaire and Modified Nordic Musculoskeletal Questionnaire was filled in by 30,520 hospital workers in 37 hospitals selected randomly from among all public hospitals of Shandong, China. The 12-month prevalence of NSP lasting for at least 3 months and sick leave absence due to NSP among 29,547 public hospital workers was 15.6% and 11.4%, respectively, most frequently reported in tertiary hospital workers (27.4% and 18.9%) and clinicians (19.1% and 15.2%). Log-binomial regression analysis revealed that chronic NSP was significantly associated with hospital level, employment position, contract/temporary employment status (vs. permanent), workload (long work hours per week), ergonomic factors (bending the neck forward for long periods of time, twisting the neck for long periods of time) and computer-related factors (prolonged computer-using time daily, the keyboard too close to the edge of the desk).
Reoperations for structurally persistent or recurrent disease after thyroidectomy: analysis via preoperative CT
Authors: Kim Hyeung Kyoo , Ha Eun Ju , Han Miran , Lee Jeonghun , Soh Euy Young 
Published: July 2020

AbstractThe incidence rates of structural persistent disease (PD) and recurrent disease (RD) after thyroidectomy, and their clinicoradiological (CT) characteristics, remain poorly understood. Therefore, we characterized differentiated thyroid cancer (DTC) patients who underwent re-operations, with a focus on preoperative CT scans. We examined neck CT scans obtained prior to initial surgery and reoperation, and classified the disease into four categories according to the persistence/recurrence and neck dissection/non-dissection status. In total, 121 of 9,173 DTC patients underwent reoperations to treat PD or RD; the mean time to reoperation was 25.5 and 54.1 months, respectively. Of all reoperations, 19% (23/121) were performed to treat RD; 81% (98/121) were performed to treat PD. Compared to RD, PD was commonly detected in the non-dissected neck. Tumor multiplicity and the number of pathologically positive lymph nodes were greater in the non-dissected than dissected neck. A review of the CT data revealed more false-negative findings on the 60-s- versus 30–40-s-delay scans of PD patients with non-dissected necks. In conclusion, most of the reoperations performed on DTC patients were for management of PD. Improved preoperative CT assessments and initial surgery, based on the information of clinico-radiological characteristics, are required in the care of DTC patients.
Beneficial effects of IL-4 and IL-6 on rat neonatal target cardiac cells
Authors: Zogbi Camila , Oliveira Nathalia C. , Levy Débora , Bydlowski Sergio P. , Bassaneze Vinicius , Neri Elida A. , Krieger Jose E. 
Published: July 2020

AbstractThe nature of the early post-natal immune response in rodents appears to influence cardiac regeneration even though the underlying molecules remain poorly understood. Consistent with this idea, we show now significant changes in the expression of immune and cell movement gene pathways in heart samples from 1- and 7-day-old rats with ventricle resection. We then tested whether conditioned media from adult M2 anti-inflammatory macrophages target neonatal cardiac cells to a pro-regenerative like phenotype compared to the M1 pro-inflammatory macrophages. We found that M2 compared to M1 macrophage-conditioned media upregulates neonatal cardiomyocyte proliferation, suppresses myofibroblast-induced differentiation and stimulates endothelial cell tube formation. Using a cytokine array, we selected four candidate cytokine molecules uniquely expressed in M2 macrophage-conditioned media and showed that two of them (IL-4 and IL-6) induce endothelial cell proliferation whilst IL-4 promotes proliferation in neonatal cardiomyocytes and prevents myofibroblast-induced collagen type I secretion. Altogether, we provided evidence that adult M2 macrophage-conditioned media displays a paracrine beneficial pro-regenerative response in target cardiac cells and that IL-4 and IL-6 recapitulate, at least in part, these pleiotropic effects. Further characterization of macrophage immune phenotypes and their secreted molecules may give rise to novel therapeutic approaches for post-natal cardiac repair.
Realization of photonic charge-2 Dirac point by engineering super-modes in topological superlattices
Authors: Hu Mengying , Ding Kun , Qiao Tong , Jiang Xi , Wang Qiang , Zhu Shining , Liu Hui 
Published: July 2020

AbstractQuite recently, an unconventional variety of fourfold linear band degeneracy points has been discovered in certain condensed-matter systems. Contrary to standard 3-D Dirac monopoles, these quadruple points known as the charge-2 Dirac points are characterized by nonzero topological charges, which can be exploited to delve into hitherto unknown realms of topological physics. Here, we report on the experimental realization of a charge-2 Dirac point by deliberately engineering hybrid topological states, called super-modes, in a 1-D optical superlattice system with synthetic dimensions. Utilizing direct reflection and transmission measurements, we propose the existence of the synthetic charge-2 Dirac point in the visible region. We also show an experimental approach to manipulating two spawned Weyl points possessing equal charge. Topological end modes resulting from the charge-2 Dirac point can be delicately controlled within truncated superlattices, opening a pathway to rationally engineer local fields with intense enhancement.
Identification of cell division cycle 20 as a candidate biomarker and potential therapeutic target in bladder cancer using bioinformatics analysis
Authors: Shen Peilin , He Xuejun , Lan Lin , Hong Yingkai , Lin Mingen 
Published: July 2020

Abstract
Purpose: As bladder cancer (BC) is very heterogeneous and complicated in the genetic level, exploring genes to serve as biomarkers and therapeutic targets is practical.
Materials and methods: We searched Gene Expression Omnibus (GEO) and downloaded the eligible microarray datasets. After intersection analysis for identified differentially expressed genes (DEGs) of included datasets, overlapped DEGs were identified and subsequently analyzed with Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Protein–Protein Interaction (PPI) and hub genes identification. Hub genes were further analyzed with mRNA expression comparation in Oncomine and Gene Expression Profiling Interactive Analysis (GEPIA) database, proteomics-based validation in The Human Protein Atlas (THPA) and survival analysis in GEO and Oncolnc database.
Results: We analyzed five eligible GEO datasets and identified 76 overlapped DEGs mapped into PPI network with 459 edges which were mainly enriched in cell cycle pathway and related terms in GO and KEGG analysis. Among five identified hub genes, which are Cyclin-Dependent Kinase 1 (CDK1), Ubiquitin-Conjugating Enzyme E2 C (UBE2C), Cell Division Cycle 20 (CDC20), Microtubule Nucleation Factor (TPX2) and Cell Division Cycle Associated 8 (CDCA8); CDC20 and CDCA8 were confirmed as significant in mRNA expression comparation and proteomics-based validation. However, only CDC20 was considered prognostically significant in both GEO and Oncolnc database.
Conclusions: CDC20 and CDCA8 were identified as candidate diagnostic biomarkers for BC in the present study; however, only CDC20 was validated as prognostically valuable and may possibly serve as a candidate prognostic biomarker and potential therapeutic target. Still, further validation studies are essential and indispensable.
GJ 357 b
Authors: Modirrousta-Galian D. , Stelzer B. , Magaudda E. , Maldonado J. , Güdel M. , Sanz-Forcada J. , Edwards B. , Micela G. 
Published: July 2020

Aims. In this paper we present a deep X-ray observation of the nearby M dwarf GJ 357 and use it to put constraints on the atmospheric evolution of its planet, GJ 357 b. We also analyse the systematic errors in the stellar parameters of GJ 357 in order to see how they affect the perceived planetary properties.
Methods. By comparing the observed X-ray luminosity of its host star, we estimate the age of GJ 357 b as derived from a recent XMM-Newton observation (log Lx [erg s−1] = 25.73), with Lx− age relations for M dwarfs. We find that GJ 357 presents one of the lowest X-ray activity levels ever measured for an M dwarf, and we put a lower limit on its age of 5 Gyr. Using this age limit, we performed a backwards reconstruction of the original primordial atmospheric reservoir. Furthermore, by considering the systematic errors in the stellar parameters, we find a range of possible planetary masses, radii, and densities.
Results. From the backwards reconstruction of the irradiation history of GJ 357 b’s we find that the upper limit of its initial primordial atmospheric mass is ~38 M⊕. An initial atmospheric reservoir significantly larger than this may have survived through the X-ray and ultraviolet irradiation history, which would not be consistent with current observations that suggest a telluric composition. However, given the relatively small mass of GJ 357 b, even accreting a primordial envelope ≳10 M⊕ would have been improbable as an unusually low protoplanetary disc opacity, large-scale migration, and a weak interior luminosity would have been required. For this reason, we discard the possibility that GJ 357 b was born as a Neptunian- or Jovian-sized body. In spite of the unlikelihood of a currently existing primordial envelope, volcanism and outgassing may have contributed to a secondary atmosphere. Under this assumption, we present three different synthetic IR spectra for GJ 357 b that one might expect, consisting of 100% CO2, 100% SO2, and 75% N2, 24% CO2 and 1% H2O, respectively. Future observations with space-based IR spectroscopy missions will be able to test these models. Finally, we show that the uncertainties in the stellar and planetary quantities do not have a significant effect on the estimated mass or radius of GJ 357 b.
Membranöse Glomerulonephritis
Authors: Stahl Rolf A. K. , Hoxha Elion 
Published: July 2020

ZUSAMMENFASSUNGDie membranöse Glomerulonephritis (MGN) ist die häufigste Ursache eines nephrotischen Syndroms bei Erwachsenen. Die MGN ist eine Autoimmunerkrankung, die durch die Bindung von Antikörpern an Proteine glomerulärer Podozyten entsteht. Die Folge ist das Auftreten einer Proteinurie. Die MGN hat eine Spontanremissionsrate von nahezu 30 %, führt aber gleichzeitig bei weiteren 25 % der Erkrankten zu einem progressiven Nierenfunktionsverlust. Mit der Entdeckung von Autoantikörpern gegen den Phospholipase-A2-Rezeptor 1 (PLA2R1) und Thrombospondin Type 1 Domain Containing 7 A (THSD7A), die in der Entstehung der Erkrankung eine wichtige Rolle spielen, hat sich nicht nur das Verständnis der Pathogenese der MGN, sondern auch die Diagnose und Betreuung der Patienten deutlich verbessert. Autoantikörper gegen den PLA2R1 sind bei ca. 85 % der Patienten mit MGN nachweisbar, während bei 2–3 % der Patienten THSD7A-Antikörper vorhanden sind. Die Messung der Antikörperspiegel und immunhistologische Färbungen der Antigene in Nierenbiopsien ermöglichen eine nahezu 100-prozentige Diagnose einer PLA2R1- oder THSD7A-vermittelten MGN. PLA2R1-Antikörperspiegel sind Prädiktoren für das Ansprechen einer Therapie, bestimmen die Prognose und ermöglichen eine exakte individuelle Steuerung der Therapie. THSD7A-Antikörper sind mit einer erhöhten Inzidenz von Malignomen verbunden und spielen eine pathogenetische Rolle in der Entstehung dieser „sekundären“ Form der MGN. PLA2R1- und THSD7A-Antikörper sind ideale Biomarker bei der Einschätzung des klinischen Verlaufs der MGN und erlauben eine individuelle Betreuung der Patienten. Die Charakterisierung der für die Entstehung der MGN verantwortlichen Antigene und Antikörper ist eine gute Voraussetzung für die Entwicklung neuer, auch kurativer Therapien.
Lupusnephritis
Authors: Oelzner Peter , Amann Kerstin 
Published: July 2020

ZUSAMMENFASSUNGDie Lupusnephritis (LN) als prognosebestimmende Manifestation des systemischen Lupus erythematodes betrifft ca. 50 % der Patienten. Die Nierenbiopsie ermöglicht auf Basis der Klassifikation und der Bestimmung von Aktivitäts- und Chronizitätsindex eine gezielte Therapie und gibt wichtige Informationen zur Prognose. Bei der häufigsten Form der LN, der proliferativen LN, auch in Kombination mit einer membranösen LN, erfolgt eine Remissionsinduktion mit einer intravenösen (i. v.) Low-Dose-Cyclophosphamid-Therapie (6-mal 500 mg) oder mit Mycophenolatmofetil (MMF) kombiniert mit initial hoch dosierten Glukokortikoiden (GK), gefolgt von einer Remissionserhaltung mit Azathioprin oder MMF. Wichtige Therapieziele sind möglichst komplette renale Remission, gekennzeichnet durch den Erhalt einer zumindest annährend normalen Nierenfunktion, und eine weitgehende Reduktion der Proteinurie. Eine komplette Remission wird aktuell nach 2 Jahren bei 40–60 % der Patienten erreicht. Neuere Therapieansätze zielen neben einer verbesserten Effektivität auf eine geringere Toxizität und weitestgehende Reduktion von GK und umfassen den Einsatz von Biologika sowie die Multitarget-Therapie mit konventionellen Immunsuppressiva.
Schulabsentismus – Voraussetzungen einer erfolgreichen
Therapie
Authors: Hilwerling Lorenz , Linnenbank Marie , Flockert Heike , Wedemeyer Marei , Warnking Gerrit , Blanke Jenny , Berlage Paul , Schomberg Daniela , Weglage Josef 
Published: July 2020

Zusammenfassung
Einleitung Schulabsentismus (schulvermeidendes Verhalten über
einen längeren Zeitraum) ist ein wachsendes und massives Problem, das
zunehmend auch Kinderärzte als erste Ansprechpartner beschäftigt
und 2–5% aller schulpflichtigen Kinder und Jugendlichen betrifft
[3]. Prognostisch stellt Schulabsentismus ein hohes Risiko für
späteres Schulversagen, Drogenabusus, Arbeitslosigkeit, chronisch
psychiatrische Erkrankung und Delinquenz dar [2, 3, 10]. Für chronische
Schulabsentisten fehlen effektive Behandlungsmöglichkeiten.
Methoden Im Zeitraum 2016–2019 wurden in einer auf
Schulabsentismus spezialisierten psychiatrischen Tagesklinik 67 psychiatrisch
erkrankte Patienten mit Schulabsentismus von 3 Monaten bis 2 Jahren (Median: 8
Monate) im Alter von 7–17 Jahren in einem multimodalen Therapiesetting
behandelt. 93% der Patienten hatten frustrane Psychotherapieversuche im
Vorfeld hinter sich.
Ergebnisse 55 von 67 Patienten (82%) konnten auch 6 Monate nach
Entlassung aus der Tagesklinik einen regelmäßigen Schulbesuch
berichten.
Schlussfolgerungen Entscheidend für den Behandlungserfolg bei
Schulabsentismus ist eine Behandlung „aus einem Guss“. Dazu
gehört 1. eine aufs engste verzahnte intensive psychiatrische Behandlung
der Patienten und -wo nötig- auch der Bezugspersonen (Eltern)
außerhalb und im thematisch spezialisierten schulischen Kontext mit
langfristiger, sektorenübergreifender Begleitung
(Therapeutenkontinuität), 2. ein hocheffizientes Modelllernen im
Kleingruppenkontext ähnlich betroffener Patienten mit (multi-)
familientherapeutischer Einbettung, 3. ein verlässlicher, psychologisch
geschulter Hol- und Bringdienst, der die Patienten notfalls morgens „aus
dem Bett holt“ und 4. eine enge Kooperation mit den Heimatschulen.
Planned versus Unplanned Delivery for Placenta Accreta Spectrum
Authors: Fishel Bartal Michal , Papanna Ramesha , Zacharias Nikolaos M. , Soriano-Calderon Neomary , Limas Maria , Blackwell Sean C. , Chen Han-Yang , Chauhan Suneet P. , Sibai Baha M. 
Published: July 2020

Objective Women with placenta accreta spectrum (PAS) having an unplanned delivery may have worse outcome compared with women with a planned delivery. The primary objective of this study was to compare severe maternal morbidity among women with PAS who had a planned scheduled delivery versus an unplanned delivery. Secondary objective was to compare neonatal outcomes.
Study Design Retrospective cohort study at two tertiary centers (January 2009 to June 2019) of all women who underwent a hysterectomy with a histologic proven PAS. Primary outcome was severe maternal morbidity which defined as any of the following: transfusion of ≥4 RBC units or ureter/bowel injury. Neonatal outcome was a composite neonatal morbidity defined as any of the following: Apgar score's < 5 at 5 minutes, mechanical ventilation, or respiratory distress syndrome. Maternal demographic, clinical, and sonographic characteristics were compared between the two groups (planned vs. unplanned). Descriptive statistics were used as appropriate, and a statistical significance was established if p-value was < 0.05.
Results Of 109 women who underwent cesarean hysterectomy for PAS, 41 (37.6%) had an unplanned delivery. There was no significant difference in the number of previous cesarean deliveries or ultrasound findings between the two groups. Women with an unplanned delivery were more likely to bleed during pregnancy than those that had a planned delivery (p = 0.04). Women with unplanned delivery had lower gestational age at delivery (30.3 vs. 33.8 weeks, p = 0.001) had a 75% higher rate of the primary outcome (63 vs. 36%, p = 0.007) and had a higher rate of intensive care unit admissions (39 vs. 17.7%, p = 0.01) compared with women with a planned delivery. The neonatal morbidity did not differ between the two groups.
Conclusion Since unplanned cesarean hysterectomy among women with PAS occurs in 40% and is associated with significantly higher morbidity, interventions are needed to mitigate the rate of adverse outcomes.
Key Points