bluuebunny/crossref_metadata_2025_split huggingface dataset:
Object tracking framework with Siamese network and re-detection mechanism
Authors: Li Daqun , Yu Yi , Chen Xiaolin 
Published: November 2019

AbstractTo improve the deficient tracking ability of fully-convolutional Siamese networks (SiamFC) in complex scenes, an object tracking framework with Siamese network and re-detection mechanism (Siam-RM) is proposed. The mechanism adopts the Siamese instance search tracker (SINT) as the re-detection network. When multiple peaks appear on the response map of SiamFC, a more accurate re-detection network can re-determine the location of the object. Meanwhile, for the sake of adapting to various changes in appearance of the object, this paper employs a generative model to construct the templates of SiamFC. Furthermore, a method of template updating with high confidence is also used to prevent the template from being contaminated. Objective evaluation on the popular online tracking benchmark (OTB) shows that the tracking accuracy and the success rate of the proposed framework can reach 79.8% and 63.8%, respectively. Compared to SiamFC, the results of several representative video sequences demonstrate that our framework has higher accuracy and robustness in scenes with fast motion, occlusion, background clutter, and illumination variations.
Ulam stability of Caputo q-fractional delay difference equation: q-fractional Gronwall inequality approach
Authors: Butt Rabia Ilyas , Abdeljawad Thabet , Alqudah Manar A. , Rehman Mujeeb ur 
Published: November 2019

AbstractIn this article, we discuss the existence and uniqueness of solution of a delay Caputo q-fractional difference system. Based on the q-fractional Gronwall inequality, we analyze the Ulam–Hyers stability and the Ulam–Hyers–Rassias stability. An example is provided to support the theoretical results.
Maximum principle and its application to multi-index Hadamard fractional diffusion equation
Authors: Ren Xueyan , Wang Guotao , Bai Zhanbing , El-Deeb A. A. 
Published: November 2019

AbstractThis study establishes some new maximum principle which will help to investigate an IBVP for multi-index Hadamard fractional diffusion equation. With the help of the new maximum principle, this paper ensures that the focused multi-index Hadamard fractional diffusion equation possesses at most one classical solution and that the solution depends continuously on its initial boundary value conditions.
Basic theory of differential equations with linear perturbations of second type on time scales
Authors: Zhao Yige , Sun Yibing , Liu Zhi , Bai Zhanbing 
Published: November 2019

AbstractIn this paper, we develop the theory of differential equations with linear perturbations of second type on time scales. An existence theorem for differential equations with linear perturbations of second type on time scales is given under$\mathscr{D}$D-Lipschitz conditions. Some fundamental differential inequalities on time scales, which are utilized to investigate the existence of extremal solutions, are also presented. The comparison principle on differential equations with linear perturbations of second type on time scales is established. Our results in this paper extend and improve some well-known results.
On type 2 degenerate Bernoulli and Euler polynomials of complex variable
Authors: Kim Taekyun , Kim Dae San , Jang Lee-Chae , Kim Han-Young 
Published: November 2019

AbstractRecently, Masjed-Jamei, Beyki, and Koepf studied the so-called new type Euler polynomials without using Euler polynomials of complex variable. Here we study the type 2 degenerate cosine-Euler and type 2 degenerate sine-Euler polynomials, which are type 2 degenerate versions of these new type Euler polynomials, by considering the degenerate Euler polynomials of complex variable and by treating the real and imaginary parts separately. In addition, we investigate the corresponding ones for Bernoulli polynomials in the same manner. We derive some explicit expressions for those new polynomials and some identities relating to them. Here we note that the idea of separating the real and imaginary parts separately gives an affirmative answer to the question asked by Hacène Belbachir.
Immune pressures drive the promoter hypermethylation of neoantigen genes
Authors: Yi Ming , Dong Bing , Chu Qian , Wu Kongming 
Published: November 2019

AbstractCancer cells with strong immunogenicity are susceptible for elimination by cancer immunoediting, while the subpopulations with weak immunogenicity survive. As a result, a subset of cancer cells evade the immune attack and evolve into overt clinical lesions. During cancer evolution, it has been well established that multiple alterations such as the dysfunction of antigen presentation machinery and the upregulation of immunosuppressive signals (e.g. PD-L1) play important roles in immune escape. Recently, promoter hypermethylation of neoantigen genes has been proposed to be a vital mechanism of immunoediting. This epigenetically mediated immune evasion enriches the mechanisms of carcinogenesis.
Alexithymia predicts maladaptive but not adaptive emotion regulation strategies in adolescent girls with anorexia nervosa or depression
Authors: Sfärlea Anca , Dehning Sandra , Keller Lena Katharina , Schulte-Körne Gerd 
Published: November 2019

Abstract
Background
Among adolescent girls, anorexia nervosa (AN) and major depression (MD) are common and often comorbid mental health problems. Both disorders are characterised by difficulties in recognising and verbalising (alexithymia) as well as regulating one’s emotions, but research in adolescent patients is scarce and little is known about the relation between alexithymia and difficulties in emotion regulation. The aims of this study were to investigate alexithymia and emotion regulation skills in adolescents with AN, adolescents with MD, and healthy adolescents, and to determine whether alexithymia functions as a predictor for emotion regulation skills.

Methods
Emotion regulation strategies, alexithymia, and depressive symptoms were assessed by questionnaire measures in 12–18 year old girls with AN (n = 26), girls with MD (n = 25), and healthy girls (n = 35). Groups were compared with respect to the these variables and multiple regression analyses were calculated separately for adaptive and maladaptive emotion regulation strategies in order to examine if alexithymia predicted emotion regulation over and above age and depressive symptoms.

Results
Girls with AN or MD both reported using adaptive emotion regulation strategies less frequently and maladaptive emotion regulation skills more frequently as well as higher levels of alexithymia compared to healthy girls. Alexithymia positively predicted maladaptive emotion regulation strategies, while depressive symptoms negatively predicted adaptive emotion regulation strategies.

Conclusions
The results suggest that different mechanisms may underlie the lack of adaptive and the surplus of maladaptive emotion regulation strategies in adolescent psychiatric patients.
Dual-energy spectral CT characteristics in surgically resected lung adenocarcinoma: comparison between Kirsten rat sarcoma viral oncogene mutations and epidermal growth factor receptor mutations
Authors: Li Meng , Zhang Li , Tang Wei , Duan Jian-Chun , Jin Yu-Jing , Qi Lin-Lin , Wu Ning 
Published: November 2019

Abstract
Background
Kirsten rat sarcoma viral oncogene homolog (KRAS) and epidermal growth factor receptor (EGFR) are the two most frequent and well-known oncogene of lung adenocarcinoma. The purpose of this study is to compare the characteristics measured with dual-energy spectral computed tomography (DESCT) in lung adenocarcinoma patients who have KRAS and EGFR gene mutations.

Methods
Patients with surgically resected lung adenocarcinoma (n = 72) were enrolled, including 12 patients with KRAS mutations and 60 patients with EGFR mutations. DESCT quantitative parameters, including the CT number at 70 keV, the slopes of the spectral attenuation curves (slope λ HU), normalized iodine concentration (NIC), normalized water concentration (NWC), and effective atomic number (effective Z), were analyzed. A multiple logistic regression model was applied to discriminate clinical and DESCT characteristics between the types of mutations.

Results
The KRAS mutation was more common in people who smoked than the EGFR mutation. Nodule type differed significantly between the KRAS and EGFR groups (P = 0.035), and all KRAS mutation adenocarcinomas were solid nodules. Most DESCT quantitative parameters differed significantly between solid nodules and subsolid nodules. CT number at 70 keV, slope λ HU, NIC, and effective Z differed significantly between the KRAS and EGFR groups (P = 0.006, 0.017, 0.013 and 0.010) with solid lung adenocarcinoma. Multivariate logistic analysis of DESCT and clinical features indicated that besides smoking history, the CT value at 70 keV (OR = 0.938, P = 0.009) was significant independent factor that could be used to differentiate KRAS and EGFR mutations in solid lung adenocarcinoma.

Conclusions
DESCT would be a potential tool to differentiate lung adenocarcinoma patients with a KRAS mutation from those with an EGFR mutation.
Lesion measurement on a combined “all-in-one” window for chest CT: effect on intra- and interobserver variability
Authors: Snoeckx Annemiek , Cant Jeroen , Franck Caro , Luyckx Elisa , Carpentier Ken , Nicolay Simon , Van Hoyweghen Astrid , Spinhoven Maarten J. , Vuylsteke Pieter , Parizel Paul M. 
Published: November 2019

Abstract
Purpose
A newly developed image processing technique fuses conventional windows into a single ‘All-In-One’ (AIO) window. This study aims to evaluate variability of CT measurement of lesions in thoracic oncology patients on this novel AIO-window.

Methods
Six radiologists with different levels of expertise measured 368 lesions of various size, origin and sharpness. All lesions were measured twice on the AIO-window and twice on the conventional window settings. Intraclass correlation coefficients and Bland-Altman plots were used to assess intra- and interobserver variability.

Results
Overall intra-observer agreement for lesion diameters on the AIO-window and conventional window settings was 0.986 (95% Confidence interval (CI): 0.983–0.989) and 0.991 (95% CI 0.989–0.993) respectively. For interobserver agreement this was 0.982 (95% CI 0.979–0.985) (AIO) and 0.979 (95% CI 0.957–0.982) (conventional). For both the AIO and conventional windows, intra- and interobserver agreement were dependent on size, sharpness and reader experience. Measurement variability decreased with increasing lesion size. Regarding sharpness, inter- and intra-observer agreement ranged from 0.986–0.989 (AIO) and 0.985–0.992 (conventional) for well-defined lesions and from 0.978–0.983 (AIO) and 0.974–0.991 (conventional) for ill-defined lesions.

Conclusions
Lesion diameters were consistently smaller on the AIO-window compared to conventional window settings. Overall intra- and interobserver variability rates were similar for the AIO-window and conventional window settings. We conclude that the AIO-window offers a reliable and reproducible alternative for measurement of thoracic lesions.
Efficiency of rice husk ash and fly ash as reactivity materials in sustainable concrete
Authors: Amin Mohamed , Abdelsalam Bassam Abdelsalam 
Published: November 2019

AbstractMany environmental problems occur due to rice husk burning and emissions from coal-fired power stations. This paper presents the recycling of rice husk ash (RHA) and fly ash (FA) from power plants as reactivity materials for producing sustainable (green) concrete. This research aims to investigate the efficiency of RHA and FA replacement ratios on fresh and hardened properties of concrete mixtures. The experimental program consisted of 21 concrete mixtures, which were divided into three groups. The cementitious material contents were 350, 450 and 550 kg m−3for groups one, two and three, respectively. The replacement ratios from the cement content were 10, 20 and 30% respectively, for each recycle material (RHA and FA). The slump and air contents of fresh concrete were measured. The compressive strength, splitting tensile strength, flexural strength, modulus of elasticity and bond strength of hardened concrete as mechanical properties were also analyzed. The compressive strength was monitored at different ages: 3, 7, 28, 60 and 90 d. The water permeability test of hardened concrete as physical properties was conducted. Test results showed that the RHA and FA enhanced the mechanical and physical properties compared with the control mixture. The cementitious content of 450 kg m−3exhibited better results than other utilized contents. In particular, the replacement ratios of 10 and 30% of RHA presented higher mechanical properties than those of FA for each group. The water permeability decreased as the cementitious content increased due to the decrease in air content for all mixtures. The water permeability loss ratios increased as the cementitious content decreased.
Paraneoplastic β Cell Dedifferentiation in Nondiabetic Patients with Pancreatic Cancer
Authors: Wang Yichen , Ni Qicheng , Sun Jiajun , Xu Min , Xie Jing , Zhang Jun , Fang Yuan , Ning Guang , Wang Qidi 
Published: November 2019

Abstract

Context
Beta-cell dedifferentiation was recently proposed as a mechanism of β-cell dysfunction, but whether it can be a trigger of β-cell failure preceding hyperglycemia in humans is uncertain. Pancreatic cancer can cause new-onset diabetes, yet the underlying mechanism is unknown.

Objective
To investigate whether β-cell dedifferentiation is present in nondiabetic pancreatic ductal adenocarcinoma (PDAC) patients, we examined pancreatic islets from 15 nondiabetic patients with benign tumors (control) and 15 nondiabetic PDAC patients.

Design
We calculated the number of hormone-negative endocrine cells and evaluated important markers of β-cell dedifferentiation and function in the paraneoplastic islets. We assessed tumor-related inflammatory changes under the pancreatic cancer microenvironment and their influence on β-cell identity.

Results
We found nearly 10% of nonhormone expressing endocrine cells in nondiabetic PDAC subjects. The PDAC islets were dysfunctional, evidenced by low expression of Glucose transporter 2 (GLUT2) and Urocortin3 (UCN3), and concomitant upregulation of Aldehyde Dehydrogenase 1 Family Member A3 (ALDH1A3) expression and proinsulin accumulation. Pancreatic cancer caused paraneoplastic inflammation with enhanced tissue fibrosis, monocytes/macrophages infiltration, and elevated inflammatory cytokines. Moreover, we detected β-cell dedifferentiation and defects in GSIS in islets exposed to PANC-1 (a cell line established from a pancreatic carcinoma of ductal origin from a 56-year-old Caucasian male)-conditioned medium. In a larger cohort, we showed high prevalence of new-onset diabetes in PDAC subjects, and fasting blood glucose (FBG) was found to be an additional useful parameter for early diagnosis of PDAC.

Conclusions
Our data provide a rationale for β-cell dedifferentiation in the pathogenesis of pancreatic cancer–associated diabetes. We propose that β-cell dedifferentiation can be a trigger for β-cell failure in humans, before hyperglycemia occurs.
Lar maintains the homeostasis of the hematopoietic organ in Drosophila by regulating insulin signaling in the niche
Authors: Kaur Harleen , Sharma Shiv Kumar , Mandal Sudip , Mandal Lolitika 
Published: November 2019

ABSTRACT
Stem cell compartments in metazoa get regulated by systemic factors as well as local stem cell niche-derived factors. However, the mechanisms by which systemic signals integrate with local factors in maintaining tissue homeostasis remain unclear. Employing the Drosophila lymph gland, which harbors differentiated blood cells, and stem-like progenitor cells and their niche, we demonstrate how a systemic signal interacts and harmonizes with local factor/s to achieve cell type-specific tissue homeostasis. Our genetic analyses uncovered a novel function of Lar, a receptor protein tyrosine phosphatase. Niche-specific loss of Lar leads to upregulated insulin signaling, causing increased niche cell proliferation and ectopic progenitor differentiation. Insulin signaling assayed by PI3K activation is downregulated after the second instar larval stage, a time point that coincides with the appearance of Lar in the hematopoietic niche. We further demonstrate that Lar physically associates with InR and serves as a negative regulator for insulin signaling in the Drosophila larval hematopoietic niche. Whether Lar serves as a localized invariable negative regulator of systemic signals such as insulin in other stem cell niches remains to be explored.
The Paf1 complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors
Authors: Jurynec Michael J. , Bai Xiaoying , Bisgrove Brent W. , Jackson Haley , Nechiporuk Alex , Palu Rebecca A. S. , Grunwald Hannah A. , Su Yi-Chu , Hoshijima Kazuyuki , Yost H. Joseph , Zon Leonard I. , Grunwald David Jonah 
Published: November 2019

ABSTRACT
Multipotent progenitor populations are necessary for generating diverse tissue types during embryogenesis. We show the RNA polymerase-associated factor 1 complex (Paf1C) is required to maintain multipotent progenitors of the neural crest (NC) lineage in zebrafish. Mutations affecting each Paf1C component result in near-identical NC phenotypes; alyron mutant embryos carrying a null mutation in paf1 were analyzed in detail. In the absence of zygotic paf1 function, definitive premigratory NC progenitors arise but fail to maintain expression of the sox10 specification gene. The mutant NC progenitors migrate aberrantly and fail to differentiate appropriately. Blood and germ cell progenitor development is affected similarly. Development of mutant NC could be rescued by additional loss of positive transcription elongation factor b (P-TEFb) activity, a key factor in promoting transcription elongation. Consistent with the interpretation that inhibiting/delaying expression of some genes is essential for maintaining progenitors, mutant embryos lacking the CDK9 kinase component of P-TEFb exhibit a surfeit of NC progenitors and their derivatives. We propose Paf1C and P-TEFb act antagonistically to regulate the timing of the expression of genes needed for NC development.
The plakin domain of C. elegans VAB-10/plectin acts as a hub in a mechanotransduction pathway to promote morphogenesis
Authors: Suman Shashi Kumar , Daday Csaba , Ferraro Teresa , Vuong-Brender Thanh , Tak Saurabh , Quintin Sophie , Robin François , Gräter Frauke , Labouesse Michel 
Published: November 2019

ABSTRACT
Mechanical forces can elicit a mechanotransduction response through junction-associated proteins. In contrast to the wealth of knowledge available for focal adhesions and adherens junctions, much less is known about mechanotransduction at hemidesmosomes. Here, we focus on the C. elegans plectin homolog VAB-10A, the only evolutionary conserved hemidesmosome component. In C. elegans, muscle contractions induce a mechanotransduction pathway in the epidermis through hemidesmosomes. We used CRISPR to precisely remove spectrin repeats (SRs) or a partially hidden Src homology 3 (SH3) domain within the VAB-10 plakin domain. Deleting the SH3 or SR8 domains in combination with mutations affecting mechanotransduction, or just the part of SR5 shielding the SH3 domain, induced embryonic elongation arrest because hemidesmosomes collapse. Notably, recruitment of GIT-1, the first mechanotransduction player, requires the SR5 domain and the hemidesmosome transmembrane receptor LET-805. Furthermore, molecular dynamics simulations confirmed that forces acting on VAB-10 could make the central SH3 domain, otherwise in contact with SR4, available for interaction. Collectively, our data strongly indicate that the plakin domain plays a central role in mechanotransduction and raise the possibility that VAB-10/plectin might act as a mechanosensor.
Emphysematous Pyelonephritis: A single center review
Authors: Irfaan Albeerdy Mohammad , Shaikh Nadeem Ahmed , Jamshaid Anila , Qureshi Abdul Hafeez 
Published: November 2019

Background and Objective: Emphysematous pyelonephritis (EPN) is a rare, life-threatening necrotizing renal parenchymal infection. Traditional management of EPN with nephrectomy had a mortality of 40-50%. The purpose of this case series was to assess the management, biochemical factors, and outcome of EPN patients.
Methods: In this retrospective study, patients admitted to The Indus Hospital, Karachi with a diagnosis of EPN from January 2010 to February 2019, were grouped according to the Huang Tseng Classification (HTC). Their biochemical parameters, sensorium states and outcomes were recorded and analysed.
Results: Twenty patients were reviewed (9 males). No mortality was recorded. 11 patients (55%) were treated conservatively with only intravenous antibiotics and eight patients underwent an intervention: minimally invasive with drain placement in six patients, and invasive in four patients (two underwent subsequent nephrectomy, and two patients had nephrectomy only). One patient left against medical advice. All patients had decreased serum creatinine levels and total leucocyte counts on discharge.
Conclusion: EPN can be successfully managed conservatively for HTC Grade-1 and 2. Conservative treatment may be tried in higher grades, but poor response should lead to prompt escalation of treatment.
doi: https://doi.org/10.12669/pjms.36.ICON-Suppl.1728
How to cite this:Irfaan AM, Shaikh NA, Jamshaid A, Qureshi AH. Emphysematous Pyelonephritis: A single center review. Pak J Med Sci. Special Supplement ICON 2020. 2020;36(1):S83-S86 doi: https://doi.org/10.12669/pjms.36.ICON-Suppl.1728
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
FORMAS DE DIFUSIÓN INSTITUCIONAL DEL CONOCIMIENTO: UN PAPEL PARA RELIME
Authors: Cantoral Uriza Ricardo 
Published: November 2019

En editoriales previos se han tratado temáticas diversas, que van desde la pertenencia de Relime en índices, directorios, repositorios y bases de datos de revistas internacionales y su reflejo en los indicadores bibliométricos, hasta la necesidad de participar en la formación de una comunidad académica. Si bien la revista nace en Latinoamérica, impulsada por un grupo pionero, se le concibió e impulsó como una estrategia regional que se propuso jugar el papel de una publicación científica de clase mundial: ser global desde lo local.