bluuebunny/crossref_metadata_2025_split huggingface dataset:
T2‐weighted magnetic resonance imaging texture as predictor of low back pain: A texture analysis‐based classification pipeline to symptomatic and asymptomatic cases
Authors: Ketola Juuso H. J. , Inkinen Satu I. , Karppinen Jaro , Niinimäki Jaakko , Tervonen Osmo , Nieminen Miika T. 
Published: December 2020

AbstractLow back pain is a very common symptom and the leading cause of disability throughout the world. Several degenerative imaging findings seen on magnetic resonance imaging are associated with low back pain but none of them is specific for the presence of low back pain as abnormal findings are prevalent among asymptomatic subjects as well. The purpose of this population‐based study was to investigate if more specific magnetic resonance imaging predictors of low back pain could be found via texture analysis and machine learning. We used this methodology to classify T2‐weighted magnetic resonance images from the Northern Finland Birth Cohort 1966 data to symptomatic and asymptomatic groups. Lumbar spine magnetic resonance imaging was performed using a fast spin‐echo sequence at 1.5 T. Texture analysis pipeline consisting of textural feature extraction, principal component analysis, and logistic regression classifier was applied to the data to classify them into symptomatic (clinically relevant pain with frequency ≥30 days and intensity ≥6/10) and asymptomatic (frequency ≤7 days, intensity ≤3/10, and no previous pain episodes in the follow‐up period) groups. Best classification results were observed applying texture analysis to the two lowest intervertebral discs (L4‐L5 and L5‐S1), with accuracy of 83%, specificity of 83%, sensitivity of 82%, negative predictive value of 94%, precision of 56%, and receiver operating characteristic area‐under‐curve of 0.91. To conclude, textural features from T2‐weighted magnetic resonance images can be applied in low back pain classification.
Quality of Life Outcomes in Patients With Sinonasal Malignancy After Definitive Treatment
Authors: Philips Ramez , Agarwal Aarti , Chitguppi Chandala , Swendseid Brian , Graf Alexander , Murphy Kira , Jangro William , Rhodes Lora , Toskala Elina , Luginbuhl Adam , Curry Joseph , Nyquist Gurston , Rosen Marc , Johnson Jennifer , Rabinowitz Mindy 
Published: December 2020

Objectives/HypothesisTo describe multidimensional quality of life (QOL) outcomes in patients with sinonasal malignancies (SNM). To elucidate factors predicting worse QOL in this population.Study DesignRetrospective chart review at tertiary institution.MethodsA retrospective chart review on patients treated for SNM from 2006 to 2019 at a tertiary medical center was conducted. QOL outcomes were measured using the Hospital Anxiety and Depression Scale (HADS) and the Functional Assessment Cancer Therapy – Nasopharynx (FACT‐NP) score. A stepwise multiple linear regression analysis was conducted to assess factors predicting worse QOL.ResultsEighty‐one patients met inclusion criteria. Twelve (14.8%) patients had a subscale score >11 for anxiety (HADS‐A) or depression (HADS‐D) indicating significant anxiety or depression, at a median of 24 (8–68.5) months post treatment. The median FACT‐NP total score was 136 (110–152). On multivariable analysis, advanced T classification, single status, and worse social support survey score were significant predictors of worse HADS score. Worse social support survey score was a significant predictor of worse total FACT‐NP score.ConclusionAfter adjusting for confounders, at a median of 24 months after completion of definitive therapy for SNM, advanced T classification and single relationship status were found to be significant predictors of anxiety and depression (based on HADS). A worse social support survey score was associated with worse anxiety, depression, and QOL (based on HADS and FACT‐NP). Identifying these factors early may help to guide treatment and psychiatric referral to at‐risk individuals after the treatment of SNM.Level of Evidence3 Laryngoscope, 131:E2212–E2221, 2021
Barbed Reposition Pharyngoplasty versus Expansion Sphincter Pharyngoplasty: A Meta‐Analysis
Authors: Neruntarat Chairat , Khuancharee Kitsarawut , Saengthong Petcharat 
Published: December 2020

ObjectiveThis study was to compare barbed reposition pharyngoplasty (BRP) and expansion sphincter pharyngoplasty (ESP) in the treatment of obstructive sleep apnea (OSA).MethodsRelevant 907 articles were searched from various databases until August 2020, including PubMed, MEDLINE, EMBASE, Cochrane Library, Web of Science and Scopus, and reference lists.ResultsFour studies with a total of 208 participants were included. The mean reduction of apnea‐hypopnea index (AHI) in the BRP group was 74.03% and the mean reduction of AHI in the ESP group was 60.17%. The mean success rate in the BRP group and the ESP group was 84.96% and 79.87%, respectively. The mean difference (MD) of the change in AHI between groups was not significantly different (MD = −1.24 event/hr, 95% CI [−11.86, 9.36], P = .82). There was no significant difference in postoperative AHI, postoperative Epworth Sleepiness Scale, pain, hospital stay, time to oral diet, and the change in oxygen desaturation index in both groups whereas the analgesic requirement was lower in the BRP group. Operative time was lower in the BRP group (MD = 21.72 minutes, 95% CI [18.85, 24.60], P < .0001).ConclusionThe outcomes in both procedures are comparable in the improvement of OSA with palatal collapse. BRP is superior to ESP in term of surgical time. However, randomized clinical controlled trials with multicenter cooperation and long‐term follow‐up are essential to further demonstrate the efficacy of these procedures. Laryngoscope, 131:1420–1428, 2021
The setup and relaxation of spring upwelling in a deep, rotationally influenced lake
Authors: Roberts Derek C. , Egan Galen C. , Forrest Alexander L. , Largier John L. , Bombardelli Fabian A. , Laval Bernard E. , Monismith Stephen G. , Schladow Geoffrey 
Published: December 2020

AbstractStrong and sustained winds can drive dramatic hydrodynamic responses in density‐stratified lakes, with the associated transport and mixing impacting water quality, ecosystem function, and the stratification itself. Analytical expressions offer insight into the dynamics of stratified lakes during severe wind events. However, it can be difficult to predict the aggregate response of a natural system to the superposition of hydrodynamic phenomena in the presence of complex bathymetry and when forced by variable wind patterns. Using an array of current, temperature, and water quality measurements at the upwind shore, we detail the hydrodynamic response of deep, rotationally influenced Lake Tahoe to three strong wind events during late spring. Sustained southwesterly winds in excess of 10 m s−1 drove upwelling at the upwind shore (characteristic of non‐rotational upwelling setup), with upward excursions of deep water exceeding 70 m for the strongest event. Hypolimnetic water, with elevated concentrations of chlorophyll a and nitrate, was advected toward the nearshore, but this water rapidly returned to depth with the relaxation of upwelling after the winds subsided. The relaxation of upwelling exhibited rotational influence, highlighted by an along‐shore, cyclonic front characteristic of a Kelvin wave‐driven coastal jet, with velocities exceeding 25 cm s−1. The rotational front also produced downwelling to 100 m, transporting dissolved oxygen to depth. More complex internal wave features followed the passage of these powerful internal waves. Results emphasize the complexity of these superimposed hydrodynamic phenomena in natural systems, providing a conceptual reference for the role upwelling events may play in lake ecosystems.
Circulation of an atypical hepatitis C virus (HCV) strain at a dialysis unit in northeast India
Authors: Kalita Deepjyoti , Deka Sangeeta , Chamuah Kailash 
Published: December 2020

AbstractPatients undergoing hemodialysis are at an increased risk of hepatitis C virus (HCV) infection. The implementation of standard infection control measures can substantially decrease the risk of infections and other nosocomial infections. To study the HCV infection rates and genotypes in maintenance hemodialysis subjects in a dialysis unit. A total of 196 maintenance hemodialysis subjects were tested for HCV RNA for one year at a tertiary care teaching hospital in northeast India continuously. Genotyping was performed using direct sequencing (Sanger sequencing) of the 5′UTR‐core region. The HCV infection rate was 26.0%. On phylogenetic analysis, 29 sequences clustered around genotype 3 and subtype 3f were observed. High sequence similarities (75–100% homology) were observed among the isolated sequences. High molecular similarities in the isolates from the same dialysis unit with a high infection rate (26.0%) over a relatively short period of study (10 months) indicated an ongoing nosocomial transmission. Nosocomial transmission by subtype 3f is rare, and it has not been reported in dialysis cases previously. The strain is most likely evolving from common strains such as 3b or 3i and may spread due to migration or movement of people. Urgent implementation of adequate infection control measures is required.
Lipid metabolism in cancer progression and therapeutic strategies
Authors: Fu Yan , Zou Tiantian , Shen Xiaotian , Nelson Peter J. , Li Jiahui , Wu Chao , Yang Jimeng , Zheng Yan , Bruns Christiane , Zhao Yue , Qin Lunxiu , Dong Qiongzhu 
Published: December 2020

AbstractDysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy producers, signaling molecules, and source material for the biogenesis of cell membranes. The enhanced synthesis, storage, and uptake of lipids contribute to cancer progression. The rewiring of lipid metabolism in cancer has been linked to the activation of oncogenic signaling pathways and cross talk with the tumor microenvironment. The resulting activity favors the survival and proliferation of tumor cells in the harsh conditions within the tumor. Lipid metabolism also plays a vital role in tumor immunogenicity via effects on the function of the noncancer cells within the tumor microenvironment, especially immune‐associated cells. Targeting altered lipid metabolism pathways has shown potential as a promising anticancer therapy. Here, we review recent evidence implicating the contribution of lipid metabolic reprogramming in cancer to cancer progression, and discuss the molecular mechanisms underlying lipid metabolism rewiring in cancer, and potential therapeutic strategies directed toward lipid metabolism in cancer. This review sheds new light to fully understanding of the role of lipid metabolic reprogramming in the context of cancer and provides valuable clues on therapeutic strategies targeting lipid metabolism in cancer.
Prescribing of menopausal hormone therapy in Germany: Current status and changes between 2004 and 2016
Authors: Heinig Miriam , Braitmaier Malte , Haug Ulrike 
Published: December 2020

AbstractBackgroundPrescribing of menopausal hormone therapy (MHT) declined drastically after publication of the Women's Health Initiative's (WHI) findings in 2002, but studies on longer‐term trends and details of use are scarce.MethodsWe used the German Pharmacoepidemiological Research Database (GePaRD) containing health insurance claims data from ~25 million persons. Using data from 2004–2016, we conducted cross‐sectional analyses to determine the prevalence of MHT use overall and by type and route of administration in women aged 45–75. In longitudinal analyses, we assessed MHT use over 5 years and compared the patterns between different time periods.ResultsFrom 2004 to 2016, prevalence of systemic MHT prescriptions decreased by >60% in women aged 55–65 and by >50% in women aged 50 and 70 years old. Prevalence declined for most types and routes of administration at all ages (−16% to −79%) with some exceptions, for example, local MHT (vaginal estrogen). Among 50‐year‐old women in 2012, 6% were already prescribed systemic MHT at age 49 and of the remaining women, 16% were newly prescribed systemic MHT before age 55. At all ages, the cumulative dose of systemic MHT prescribed over 5 years was lower in the period 2012–2016 compared to 2005–2009 (−6% to −46%).ConclusionsFor most types of MHT and all age groups, prevalence declined considerably between 2004 and 2016 in Germany. The cumulative dose per MHT user also decreased, suggesting a trend towards a shorter duration of use.
The effectiveness and safety ofTripterygium wilfordiiglycosides combined with disease‐modifying anti‐rheumatic drugs in the treatment of rheumatoid arthritis: A systematic review and meta‐analysis of 40 randomized controlled trials
Authors: Zheng Wenhao , Mei Yifan , Chen Chunhui , Cai Leyi , Chen Hua 
Published: December 2020

ObjectiveThis systematic review and meta‐analysis were performed to investigate the efficacy and safety ofTripterygium wilfordiiglycosides (TG) for rheumatoid arthritis (RA) from the current literature.MethodsAn electronic search was conducted in eight databases (PubMed, EMBASE, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure, Chinese Biomedical Literature Database, Chinese VIP Database, and Wanfang Database) from inception until September 2020. Randomized controlled trials (RCTs) with risk of bias (RoB) score ≥ 4 according to the Cochrane RoB tool were included for the analyses. The primary outcome measures were duration of morning stiffness (DMS), tender joint count (TJC), swollen joint count (SJC), visual analog score (VAS), C‐reactive protein (CRP), erythrocyte sedimentation rate (ESR), and rheumatoid factor (RF). The secondary outcome measures were the total clinical effective rate and adverse events. All the analyses were used by the random effects models. The meta‐analysis was performed using RevMan 5.3 and STATA 14.0.ResultsA total of 40 RCTs with 3092 patients met our inclusion criteria. This meta‐analysis showed that TG plus DMARDs for RA could decrease the DMS (p< .001), TJC (p< .001), SJC (p< .001), VAS (p< .001), serum CRP (p< .001), ESR (p< .001), and RF (p< .001) and improve total effective rate (p< .001). In addition, TG was generally safe and well tolerated in RA patients.ConclusionDespite the limitations, the present evidence supports, at least to an extent, that TG can be recommended for routine use for RA patients. More large multicenter and high‐quality RCTs are required for further research.
The impact of impurities on the mechanical properties of recycled polyethylene
Authors: Thoden van Velzen Eggo Ulphard , Chu Sharon , Alvarado Chacon Fresia , Brouwer Marieke T. , Molenveld Karin 
Published: December 2020

AbstractThe mechanical properties of mechanically recycled polyethylene (rPE) were studied in relation to the composition of the feedstock. This composition varied in six steps from only bottle bodies from a single type of high‐density polyethylene (HDPE) to the complete composition of an industrially sorted polyethylene (PE) product, including other packaging components, other PE‐based packages, sorting faults and residual waste. The rPE with the highest impact resistance was made from the single‐grade bottle bodies. The addition of bodies made from other types of PE already reduced the impact resistance with 11%. All the other stepwise additions of packaging components and faultily sorted objects caused the impact resistance to decrease further. Conversely, the elongation at break grew with the stepwise addition of these packaging components and faultily sorted objects. From the used methods, the best analysis method to accurately determine the polymeric composition of the rPE was found to be near‐infrared‐assisted flake analysis. This method can not only be used to determine the polymeric composition, but due to the strong correlation with the impact resistance, it is also a valuable indicator for the expected mechanical properties of rPE.
On the adsorption affinity of graphene and white graphene sheets by dioxin‐like pollutants
Authors: Alvarado Raúl , Ramos‐Berdullas Nicolás , Mandado Marcos 
Published: December 2020

AbstractThe affinity of graphene and white graphene sheets by dioxin‐like pollutants was compared by means of high‐level quantum chemical calculations. 2,3,7,8‐tetrachloro‐p‐dibenzodioxin (TCDD) and 2,3,7,8‐tetrachlorodibenzofuran (TCDF) were chosen as prototypes of dioxin‐like pollutants with high toxicological activity. Large interaction energies were obtained both in graphene and white graphene surfaces, contrary to other previous works using the graphene surface only. The interactions clearly differed in the relative weight of inductive and dispersion forces, being the former more important in white graphene. Leaving thermal effects out, the stacking adsorption was energetically favored over the perpendicular in graphene whereas no difference was found in white graphene. Due to the low water solubility of dioxin‐like pollutants very small differences were obtained between gas phase and solution adsorption enthalpies. Including thermal effects, perpendicular adsorption was found to be both energetically and entropically favored over stacking at 298 K. The adsorption free energies reflected a larger affinity by white graphene than graphene by around 2–5 kcal·mol−1. Therefore, boron nitride 2D surfaces are expected to perform better than carbon 2D surfaces as adsorbents for dioxin‐like pollutants in line with recent experimental works on water contaminants.
Warming rather than elevated CO2 shifts the rhizobacterial community composition in four maize‐growing soils
Authors: Fang Rui , Yu Zhenhua , Li Yansheng , Xie Zhihuang , Wang Guanghua , Liu Xiaobing , Liu Junjie , Liu Judong , Herbert Stephen J. , Jin Jian 
Published: December 2020

AbstractClimate change may fundamentally affect the microorganisms in the rhizosphere that drive soil C and nutrient cycles. This study aimed to clarify the response of rhizobacterial community to warming and elevated CO2 (eCO2) in typical maize (Zea mays L.)‐growing soils. Under climate change, the shift of rhizobacterial community composition was assumed to be different among soils, which would be associated with the C sequestration and stability in soils. Using open‐top chambers to mimic climate warming and eCO2, we examined the taxonomic composition of bacterial communities in the rhizosphere of maize grown in four farming soils (Acrisol, Fluvisol, Kastanozem, and Phaeozem). Warming decreased the richness of the rhizobacterial community by 3.8% across the soils, but eCO2 did not significantly alter community richness. The shift in bacterial community composition was greater under warming than under eCO2, and the shift was different among soils. The abundance of Streptomyces and Gaiella significantly increased in Phaeozem and Acrisol in response to warming but not in Fluvisol or Kastanozem. Sphingomonas was suppressed in Phaeozem under warming, whereas Sphingomonas, Shinella, and Rhodospirillaceae_norank were enriched in the other three soils. Soil chemical characteristics including nitrate, Olsen P, available K, and soil organic C (SOC) were significantly associated with a number of dominant operational taxonomic units. These results indicate that the effect of warming on bacterial community composition in the rhizosphere of maize may be stronger than the effect of eCO2. Climate change led to various changes in the rhizobacterial community composition among soils that might be associated with the quality of SOC and nutrient status in different soils.
Cross-matching of allogeneic mesenchymal stromal cells eliminates recipient immune targeting
Authors: Rowland Aileen L. , Miller Donald , Berglund Alix , Schnabel Lauren V. , Levine Gwendolyn J. , Antczak Douglas F. , Watts Ashlee E. 
Published: December 2020

Abstract
Allogeneic mesenchymal stromal cells (MSCs) have been used clinically for decades, without cross-matching, on the assumption that they are immune-privileged. In the equine model, we demonstrate innate and adaptive immune responses after repeated intra-articular injection with major histocompatibility complex (MHC) mismatched allogeneic MSCs, but not MHC matched allogeneic or autologous MSCs. We document increased peri-articular edema and synovial effusion, increased synovial cytokine and chemokine concentrations, and development of donor-specific antibodies in mismatched recipients compared with recipients receiving matched allogeneic or autologous MSCs. Importantly, in matched allogeneic and autologous recipients, but not mismatched allogeneic recipients, there was increased stromal derived factor-1 along with increased MSC concentrations in synovial fluid. Until immune recognition of MSCs can be avoided, repeated clinical use of MSCs should be limited to autologous or cross-matched allogeneic MSCs. When non–cross-matched allogeneic MSCs are used in single MSC dose applications, presensitization against donor MHC should be assessed.
Analysis of the Explosive Properties of Tetrasulfur Tetranitride, S4N4
Authors: Koch Ernst‐Christian , Sućeska Muhamed 
Published: December 2020

AbstractThe explosive properties of tetrasulfur tetranitride, S4N4, are reviewed and analysed. S4N4 is an explosive compound with an impact sensitivity comparable to pentaerythritol tetranitrate (PETN) (Ei=4 J) but a friction sensitivity equal or even lower than lead azide (F=0.1–1 N). S4N4 has primary explosive properties. It has a working capacity greater than silver azide, AgN3, and is capable to initiate TNT. S4N4 shows an unusual non‐linear density/detonation velocity relationship which is due to different stability regimes of sulfur species present in the Chapman Jouguet zone. S4N4 is stable, non‐ageing, non‐toxic, insoluble in water and hence an interesting candidate for future lead tricinate replacement.
Childhood disadvantage and adolescent socioemotional wellbeing as predictors of future parenting behaviour
Authors: McAnally H.M. , Iosua E. , Sligo J.L. , Belsky J. , Spry E. , Letcher P. , Macdonald J.A. , Thomson K.C. , Olsson C.A. , Williams S. , McGee R. , Bolton A.E. , Hancox R.J. 
Published: December 2020

ABSTRACTIntroductionIn extending work on early life antecedents of parenting, we investigate associations between childhood family history of disadvantage, adolescent socioemotional wellbeing, and age at first parenthood and subsequent parenting behaviour.MethodsParent‐child interactions were recorded when participants in the longitudinal Dunedin Multidisciplinary Health and Development Study (New Zealand) had a three‐year‐old child. Data were available for 358 mothers and 321 fathers, aged between 17.7 and 41.5 at the time of their child's birth. Associations between parenting and antecedent data on socioeconomic disadvantage, adolescent wellbeing and mental health, as well as current adult mental health and age at parenting, were tested for using structural equation modelling.ResultsFamily disadvantage in childhood and lower adolescent wellbeing was associated with less positive future parenting, but only adult (not adolescent) anxiety/depression symptoms were directly associated with parenting behaviour. Childhood family disadvantage was associated with further disadvantage across the life course that included less positive parenting of the next generation. In contrast, socioemotional wellbeing during adolescence and later age of onset of parenting were associated with more positive parenting.ConclusionsReducing childhood disadvantage and improving socioemotional wellbeing during childhood and adolescence is likely to have intergenerational benefits through better parenting of the next generation.