bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting the next location: A self‐attention and recurrent neural network model with temporal context
Authors: Zeng Jun , He Xin , Tang Haoran , Wen Junhao 
Published: March 2020

AbstractNowadays, the popularity of mobile devices and location‐based services have generated a large amount of geographic data. It provides the opportunity for researchers to employ techniques to predict the next location. However, predicting the next location is difficult because it depends on temporal and spatial factors, and it is closely related to the historical behavior of users. In this article, we first analyze the geographic data of users and discover the potential behavior patterns of users. Then, we mine the relationship between user's movement behavior and temporal feature. Hence, we propose a method based on a recurrent neural network and self‐attention mechanism to predict the next location where users may visit. Our model can explore sequence regularity and extract temporal features according to historical trajectories information. Experimental results on a real‐world dataset demonstrate the effectiveness of our proposed model.
A full‐duplex radio over fiber architecture employing 12 Gbps 16 × 16 optical multiple input multiple output for next‐generation communication networks
Authors: Iqbal Saeed , Raza Aadil , Fasih Uddin Butt Muhammad , Ghafoor Salman , El‐Hajjar Mohammed 
Published: March 2020

SummaryIn this article, a full‐duplex millimeter wave (mm‐wave) enabled radio‐over‐fiber architecture is proposed for distributed antenna systems. This architecture is capable of achieving transmission of 16 × 16 optical multiple input multiple output spatial streams at 12 Gbps per spatial stream by employing wavelength division multiplexing and exploiting its other degrees of freedom such as polarization states and modes of wavelengths. A single laser source based multiwavelength comb and wavelength reuse techniques along with plastic optical fiber are employed to make the proposed architecture cost efficient. Optical heterodyne detection is performed at the radio access unit to generate mm‐wave carrier frequency at 60 GHz. Channel equalization is achieved for pulse amplitude modulation data signal by employing least mean square equalizer to mitigate the optical fiber channel effects. Our proposed system supports 16 × 12 Gbps for downlink (DL) and uplink (UL) transmissions. To evaluate the performance of the proposed system, we compare the receiver sensitivities at forward error correction limit of 3.8 ×
10−3 of bit error ratio of back to back system, employing no fiber effects, with its counterparts. We show that acceptable power penalties for the fiber lengths of 200 and 400 m are achieved for both LP01 and LP11 modes in DL and UL directions.
Synthesis of copper(II)‐zinc‐molybdenum compounds as smoke suppressants for PVC compositions
Authors: Rodolfo Antonio , Innocentini‐Mei Lucia Helena 
Published: March 2020

SummaryThe objectives of this research were a fist approach for the development of a simple route for the synthesis of smoke suppressants based on the deposition of copper (II)‐zinc‐molybdenum compounds over calcium carbonate. It also aimed the investigation of their effects onto the dehydrochlorination behavior (thermogravimetry) and heat release and smoke development (cone calorimetry), when incorporated into a reference poly(vinyl chloride) (PVC) composition. The results show that a simple synthesis route, based on the reaction of copper (II) and zinc molybdates precursors in an aqueous media over calcium carbonate, can lead to the formation of candidate smoke suppressant compounds, despite the fact that it was not possible to identify the expected molybdates through X‐ray diffractometry. When adding these compounds to a plasticized reference PVC composition, both heat and smoke peaks during the combustion process are reduced, with minor changes in the heat stability of the composition.
PEMFC Flow‐field Design, Channel/land Width Ratio Optimization
Authors: André J. , Claude E. , Sirac D. , Gastaldin D. , Rossinot E. 
Published: March 2020

AbstractThe impact of different land width and channel span configurations was evaluated on a 260 cm2 active area short stack. Polarization curves were compared at 65 °C cell output, max 7 °C cell delta T, 50% RH humidified air, ambient pressure at cell outlet, air pressure drop below 4 kPa at 1 A cm−2.Adequate opening ratio, about 50% or more is widely recognized as an optimal value to minimize contact resistance and diffusion losses at high current density. However, this work tends to show that performance optimization is linked to the total channel edge length per centimeter squared, ponderated by the opening ratio value. Total channel edge length is simply the sum of the edge length values on the flow‐field in contact with the membrane electrode assembly (MEA). Edges actually concentrate all the conditions for the reaction to occur: presence of gas phase and easy electron transport thanks to plate bulk conductivity. This could explain contrasted results existing in literature. Based on this work, a new cell design was developed allowing to reach 1 W cm−2 (extrapolated) with less than 20 kPa pressure drop (i.e., unchanged operating conditions except that pressure drop reached 10 kPa due to shallower channels compared to base case).
Effects of non‐pharmacological therapies for people with mild cognitive impairment. A Bayesian network meta‐analysis
Authors: Wang Ying‐quan , Jia Rui‐xia , Liang Jing‐hong , Li Jing , Qian Sheng , Li Jia‐yu , Xu Yong 
Published: March 2020

ObjectiveTo compare the effects of non‐pharmacological therapies (NPTs) on improving the cognition of people with mild cognitive impairment (MCI) by performing a Bayesian network meta‐analysis (NMA).MethodsWe searched eight databases for potentially eligible studies. Physical exercise (PE), cognitive stimulation (CS), cognitive training (CT), cognitive rehabilitation (CR), musical therapy (MT) and multi‐domain interventions (MI). Pairwise meta‐analyses were performed by estimating the weighted mean differences with 95% confidence interval (CI) for mini‐mental state examination. The NMA was undertaken to compare different interventions.ResultsCS, PE, MI, MT and CT may all be effective in improving the cognition of patients with MCI. CR was unable to show a significant efficacy. Our NMA ranking results suggest the effectiveness of the six NPTs to be ranked from best to worst as follows: CS, PE, MI, MT, CT and CR.ConclusionsNPT has great potential to improve the cognition of the elderly with MCI. CS has the highest probability of being the optimal NPT. However, the result should be interpreted with cautions given the limited number and small samples of included randomized controlled trials (RCTs) in this field, large diversity existing in different study designs and potential risk of bias. Future RCTs with high quality and large sample sizes are required to confirm our results.SummaryNPT, as a whole definition, has great potential to improve the cognition of the elderly with MCI. Our NMA ranking results suggest the effectiveness of the six NPTs to be ranked from best to worst as follows: CS, PE, MI, MT, CT and CR.
Variability associated with interpreting drugs within forensic hair analysis: A three‐stage interpretation
Authors: Davies Christopher , Gautam Lata , Grela Agatha , Morrissey Joanne 
Published: March 2020

AbstractHair analysis is capable of determining both an individual's long‐term drug history and a single exposure to a drug, which can be particularly important for corroborating incidents of drug‐facilitated crimes. As a source of forensic evidence that may be used in a court of law, it must be credible, impartial and reliable, yet the pathways of drug and metabolite entry into hair are still uncertain. Many variables may influence drug analysis results, most of which are outside of the control of an analyst. An individual's pharmacokinetic and metabolic responses, hair growth rates, drug incorporation routes, axial migration, ethnicity, age and gender, for example, all display interpersonal variability. At present there is little standardization of the analytical processes involved with hair analysis. Both false positives and negative results for drugs are frequently encountered, regardless of whether a person has consumed a drug or not. In this regard, we have categorized these variables and proposed a three‐stage analytical approach to facilitate forensic toxicologists, hair analysis experts, judiciaries and service users in the analytical and interpretation process.
MiR‐671‐5p plays a promising role in restraining osteosarcoma cell characteristics through targeting TUFT1
Authors: Ma Cao , Nie Zhi‐Kui , Guo Hong‐Min , Kong Yao 
Published: March 2020

AbstractThe aim of our study was to explore the roles of miR‐671‐5p in mediating biological processes of osteosarcoma (OS) cells and clinical implications. On the basis of the OS samples acquired from the GEO database, the expression difference and overall survival analyses of miR‐671‐5p and TUFT1 were determined. The expression of MiR‐671‐5p was verified using OS cell lines. 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide, wound‐healing, and Transwell assays were respectively carried out to probe whether miR‐671‐5p regulated OS cell vitality, migration, and invasion. The expression of miR‐671‐5p was downregulated in OS tissues and cell lines. High expression of MiR‐671‐5p blocked OS cell growth, migration, and invasion. TUFT1 was predicted and validated as the target of miR‐671‐5p in OS cells using in silico analysis and luciferase reporter assays. Forced expression of TUFT1 reversed the suppressive influence of miR‐671‐5p on cell viability, migration, and invasion of OS cells. Moreover, the low expression of miR‐671‐5p and the high expression of TUFT1 led to poor prognosis. Taken together, targeting miR‐671‐5p/TUFT1 may be a promising strategy for treating OS.
The immunomodulatory effects of tachykinins and their receptors
Authors: Khorasani Sahar , Boroumand Nadia , Lavi Arab Fahimeh , Hashemy Seyed Isaac 
Published: March 2020

AbstractTachykinins (TKs) are a family of neuropeptides mainly expressed by neuronal and non‐neuronal cell types, especially immune cells. Expression of TKs receptors on immune cell surfaces, their involvement in immune‐related disorders, and therefore, understanding their immunomodulatory roles have become of particular interest to researchers. In fact, the precise understanding of TKs intervention in the immune system would help to design novel therapeutic approaches for patients suffering from immune disorders. The present review summarizes studies on TKs function as modulators of the immune system by reviewing their roles in generation, activation, development, and migration of immune cells. Also, it discusses TKs involvement in three main cellular mechanisms including inflammation, apoptosis, and proliferation.
Functions of beta2‐adrenergic receptor in human periodontal ligament cells
Authors: Hamano Sayuri , Tomokiyo Atsushi , Hasegawa Daigaku , Yuda Asuka , Sugii Hideki , Yoshida Shinichiro , Mitarai Hiromi , Wada Naohisa , Maeda Hidefumi 
Published: March 2020

AbstractAdrenergic receptors (ARs) are receptors of noradrenalin and adrenalin, of which there are nine different subtypes. In particular, β2 adrenergic receptor (β2‐AR) is known to be related to the restoration and maintenance of homeostasis in bone and cardiac tissues; however, the functional role of signaling through β2‐AR in periodontal ligament (PDL) tissue has not been fully examined. In this report, we investigated that β2‐AR expression in PDL tissues and their features in PDL cells. β2‐AR expressed in rat PDL tissues and human PDL cells (HPDLCs) derived from two different patients (HPDLCs‐2G and ‐3S). Rat PDL tissue with occlusal loading showed high β2‐AR expression, while its expression was downregulated in that without loading. In HPDLCs, β2‐AR expression was increased exposed to stretch loading. The gene expression of PDL‐related molecules was investigated in PDL clone cells (2‐23 cells) overexpressing β2‐AR. Their gene expression and intracellular cyclic adenosine monophosphate (cAMP) levels were also investigated in HPDLCs treated with a specific β2‐AR agonist, fenoterol (FEN). Overexpression of β2‐AR significantly promoted the gene expression of PDL‐related molecules in 2 to 23 cells. FEN led to an upregulation in the expression of PDL‐related molecules and increased intracellular cAMP levels in HPDLCs. In both HPDLCs, inhibition of cAMP signaling by using protein kinase A inhibitor suppressed the FEN‐induced gene expression of α‐smooth muscle actin. Our findings suggest that the occlusal force is important for β2‐AR expression in PDL tissue and β2‐AR is involved in fibroblastic differentiation and collagen synthesis of PDL cells. The signaling through β2‐AR might be important for restoration and homeostasis of PDL tissue.
FAM20C phosphorylation of the RGDSVVYGLR motif in osteopontin inhibits interaction with the αvβ3 integrin
Authors: Schytte Gitte N. , Christensen Brian , Bregenov Ida , Kjøge Katarzyna , Scavenius Carsten , Petersen Steen V. , Enghild Jan J. , Sørensen Esben S. 
Published: March 2020

AbstractOsteopontin (OPN) is a ubiquitously expressed, multifunctional, and highly phosphorylated protein. OPN contains two neighboring integrin‐binding motifs, RGD and SVVYGLR, which mediate interaction with cells. Phosphorylation and proteolytic processing affect the integrin‐binding activities of OPN. Here we report that the kinase, FAM20C, phosphorylates Ser146 in the 143RGDSVVYGLR152 motif of OPN and that Ser146 is phosphorylated in vivo in human and bovine milk. Ser146 is located right next to the RGD motif and close by the regulatory thrombin and plasmin cleavage sites in the OPN sequence. Phosphorylation of Ser146 could potentially affect the proteolytic processing and the integrin‐binding activities of OPN. We show that phosphorylation of Ser146 does not affect the susceptibility of OPN for thrombin or plasmin cleavage. However, phosphorylation of Ser146 significantly reduces the RGD‐mediated interaction with the αvβ3 integrin in MDA‐MB‐435 and Moαv cells. This suggests a new mechanism by which specific phosphorylation of OPN can regulate interaction with the αvβ3 integrin and thereby affect OPN‐cell interaction.
MicroRNA‐124‐3p.1 promotes cell proliferation through Axin1‐dependent Wnt signaling pathway and predicts a poor prognosis of triple‐negative breast cancer
Authors: Yang Wenhua , Cui Guozhong , Ding Mingjian , Yang Meng , Dai Dianlu 
Published: March 2020

AbstractBackgroundTriple‐negative breast cancer (TNBC) is one subtype of breast cancer, which is characterized by an aggressive disease. It is commonly accompanied with extremely poor prognosis because of no available molecularly targeted therapy. Thus, understanding the detailed molecular mechanisms of TNBC is urgently needed.MethodsThe levels of Axis inhibition protein 1 (Axin1), Cyclin D1, c‐Myc, and miR‐124‐3p.1 were measured by quantitative real‐time PCR (qRT‐PCR). Furthermore, the breast cancer cell proliferation was measured by CCK‐8 assay, colony formation assays, and EdU staining. Xenograft model was used to show the tumor genesis of breast cancer cells. The regulatory function of miR‐124‐3p.1 on Wnt/β‐catenin signaling activation through directly targeting Axin1 was proven using qRT‐PCR, Western blot analysis, and dual‐luciferase reporter assay. To further assess the clinical significance of miR‐124‐3p.1 in the prognosis of breast cancer patients, we performed Kaplan‐Meier survival analysis and log‐rank tests.ResultsmiR‐124‐3p.1 expression was elevated in advanced TNBC patients, and high miR‐124‐3p.1 predicts poor overall survival in TNBC patients. Further data showed that miR‐124‐3p.1 downregulation diminished, while miR‐124‐3p.1 upregulation increased the growth of TNBC cells in vitro and in vivo. Finally, we proved that miR‐124‐3p.1 exerted its function via targeting tumor suppressor gene Axin1 and activating the Wnt signaling pathway.ConclusionIn summary, all the results demonstrate that miR‐124‐3p.1 promotes TNBC cell growth by controlling Axin1, suggesting that targeting miR‐124‐3p.1 might offer an effective therapeutic strategy for TNBC in the future.
The role of serum uric acid in the prediction of graft‐versus‐host disease in allogeneic hematopoietic stem cell transplantation
Authors: Ghasemi Katayoon , Parkhideh Sayeh , Kazemi Mohammad Hossein , Salimi Maryam , Salari Sina , Nalini Ronak , Hajifathali Abbas 
Published: March 2020

AbstractBackgroundUric acid (UA) level is of the valuable signs of inflammation. However, the role of UA in the outcomes of hematopoietic stem cell transplantation (HSCT) such as GVHD and patients’ overall survival is still a matter of debate. In this study, we aimed to evaluate the relationship between UA levels and GVHD incidence and overall survival in allogeneic HSCT patients.MethodsA total of 201 patients who were admitted for allogeneic transplantation at Taleghani hospital, Tehran, Iran, were considered for retrospective analysis. Serum UA levels from 1 week before transplantation until 2 weeks after transplantation were used to determine thresholds and find out the association of serum UA levels with GVHD and overall survival.ResultsWe showed that the determined thresholds using receiver operating characteristic curves have poor predictive value for GVHD and overall survival. The patients with serum UA higher than 3.4 mg/dL had 37% lower odds of GVHD incidence and 35% lower hazard of death than patients with UA lower than 3.4 mg/dL.ConclusionOur results indicated that serum UA levels lower than 3.4 mg/dL could significantly increase the incidence of GVHD and hazard of death. The antioxidant functions of UA could explain the lower incidence of GVHD in hyperuricemic patients. However, the inconsistencies of the previous studies require further investigation to elucidate the role of UA in the prediction of GVHD.
Examining the narrative roles in suicide notes
Authors: Grayson Stacey , Tzani‐Pepelasi Calli , Pylarinou Ntaniella‐Roumpini , Ioannou Maria , Artinopoulou Vasiliki 
Published: March 2020

AbstractThe present study examines suicide notes, using a sample of suicide notes from published corpora (N = 50), combined with a sample of recent suicide notes from a suicide website (N = 50). The present study proposes a model of differentiation in completed suicides. The characteristics of the suicide notes were analysed using a content dictionary developed by Giles in 2007, and the data subjected to smallest space analysis. Four themes of suicide completer were discovered: Egoistic Victim, Anomic Hero, Altruistic Professional and Fatalistic Revenger. The implications of these findings and the potential use in therapy work with suicide survivors and those with suicidal ideation are discussed, as well as suggestions for the direction of future research.
Innate immune memory of tissue-resident macrophages and trained innate immunity: Re-vamping vaccine concept and strategies
Authors: Xing Zhou , Afkhami Sam , Bavananthasivam Jegarubee , Fritz Dominik K , D’Agostino Michael R , Vaseghi-Shanjani Maryam , Yao Yushi , Jeyanathan Mangalakumari 
Published: March 2020

Abstract
In the past few years, our understanding of immunological memory has evolved remarkably due to a growing body of new knowledge in innate immune memory and immunity. Immunological memory now encompasses both innate and adaptive immune memory. The hypo-reactive and hyper-reactive types of innate immune memory lead to a suppressed and enhanced innate immune protective outcome, respectively. The latter is also named trained innate immunity (TII). The emerging information on innate immune memory has not only shed new light on the mechanisms of host defense but is also revolutionizing our long-held view of vaccination and vaccine strategies. Our current review will examine recent progress and knowledge gaps in innate immune memory with a focus on tissue-resident Mϕs, particularly lung Mϕs, and their relationship to local antimicrobial innate immunity. We will also discuss the impact of innate immune memory and TII on our understanding of vaccine concept and strategies and the significance of respiratory mucosal route of vaccination against respiratory pathogens.
HIV‐1 genetic diversity and transmitted drug resistance among newly diagnosed HIV‐1 individuals in Jiangmen, China
Authors: Guan Xin , Han Min , Li Zhiju , Wang Lihua , Zhang Donghe , Zhu Yanan , Hu Guifang 
Published: March 2020

AbstractJiangmen is one of the Guangdong‐Hong Kong‐Macao Greater Bay Areas with frequent commercial intercourse, which is responsible for human immunodeficiency virus type 1 (HIV‐1) rapid circulation and genetic evolution for recent years. As a novel HIV‐1 second‐generation recombinant was previously reported in Jiangmen but the systematic molecular epidemiological investigation was still unknown. A retrospective study on HIV‐1 genotypic characteristics and the emergence of transmitted drug resistance in this region was necessary. A total of 224 newly diagnosed HIV‐positive cases were randomly selected in Jiangmen City of Guangdong Province between 2018 and 2019. The partial gag (1080 bp), pol (840 bp), and env (460 bp) genes were amplified using nested polymerase chain reaction followed by sequencing. The phylogenetic and recombination analysis as well as HIV‐1 drug resistance were performed to surveillance. Sexual transmission was determined to be the major risk factor in Jiangmen. Phylogenetic analysis detected the genotypic distribution as follows: CRF01_AE (36.65%,70 of 191), CRF07_BC (32.46%, 62 of 191), CRF08_BC (4.71%, 9 of 191), CRF55_01B (5.24%, 10 of 191), CRF59_01B (3.14%, 6 of 191), subtype B (4.71%, 9 of 191), subtype C (1.05%, 2 of 191) as well as unique recombinant forms (12.04%, 23 of 191) consisted of seven recombinant patterns, which originated from multiple regions of China. Low‐level prevalence of Surveillance Drug Resistance Mutations (2.1%) were predicted but drug‐resistant mutations showed at a high level (15.4%) especially mutations in RT gene at position 179 were found to be the most frequent in the therapy‐naïve population. Our study highlighted the critical importance of monitoring the emerge of recombinant strains among newly diagnosed HIV‐1 individuals along with drug resistance regularly to prevent multi‐channel introduction and breakout of new HIV strains.