bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing the Analytical Value of Oncology-Related Data Based on an In-Memory Analysis Layer: Development and Assessment of the Munich Online Comprehensive Cancer Analysis Platform
Authors: Nasseh Daniel , Schneiderbauer Sophie , Lange Michael , Schweizer Diana , Heinemann Volker , Belka Claus , Cadenovic Ranko , Buysse Laurence , Erickson Nicole , Mueller Michael , Kortuem Karsten , Niyazi Maximilian , Marschner Sebastian , Fey Theres 
Published: April 2020

Background
Many comprehensive cancer centers incorporate tumor documentation software supplying structured information from the associated centers’ oncology patients for internal and external audit purposes. However, much of the documentation data included in these systems often remain unused and unknown by most of the clinicians at the sites.

Objective
To improve access to such data for analytical purposes, a prerollout of an analysis layer based on the business intelligence software QlikView was implemented. This software allows for the real-time analysis and inspection of oncology-related data. The system is meant to increase access to the data while simultaneously providing tools for user-friendly real-time analytics.

Methods
The system combines in-memory capabilities (based on QlikView software) with innovative techniques that compress the complexity of the data, consequently improving its readability as well as its accessibility for designated end users. Aside from the technical and conceptual components, the software’s implementation necessitated a complex system of permission and governance.

Results
A continuously running system including daily updates with a user-friendly Web interface and real-time usage was established. This paper introduces its main components and major design ideas. A commented video summarizing and presenting the work can be found within the Multimedia Appendix.

Conclusions
The system has been well-received by a focus group of physicians within an initial prerollout. Aside from improving data transparency, the system’s main benefits are its quality and process control capabilities, knowledge discovery, and hypothesis generation. Limitations such as run time, governance, or misinterpretation of data are considered.
Applicability of an Automated Model and Parameter Selection in the Prediction of Screening-Level PTSD in Danish Soldiers Following Deployment: Development Study of Transferable Predictive Models Using Automated Machine Learning
Authors: Karstoft Karen-Inge , Tsamardinos Ioannis , Eskelund Kasper , Andersen Søren Bo , Nissen Lars Ravnborg 
Published: April 2020

Background
Posttraumatic stress disorder (PTSD) is a relatively common consequence of deployment to war zones. Early postdeployment screening with the aim of identifying those at risk for PTSD in the years following deployment will help deliver interventions to those in need but have so far proved unsuccessful.

Objective
This study aimed to test the applicability of automated model selection and the ability of automated machine learning prediction models to transfer across cohorts and predict screening-level PTSD 2.5 years and 6.5 years after deployment.

Methods
Automated machine learning was applied to data routinely collected 6-8 months after return from deployment from 3 different cohorts of Danish soldiers deployed to Afghanistan in 2009 (cohort 1, N=287 or N=261 depending on the timing of the outcome assessment), 2010 (cohort 2, N=352), and 2013 (cohort 3, N=232).

Results
Models transferred well between cohorts. For screening-level PTSD 2.5 and 6.5 years after deployment, random forest models provided the highest accuracy as measured by area under the receiver operating characteristic curve (AUC): 2.5 years, AUC=0.77, 95% CI 0.71-0.83; 6.5 years, AUC=0.78, 95% CI 0.73-0.83. Linear models performed equally well. Military rank, hyperarousal symptoms, and total level of PTSD symptoms were highly predictive.

Conclusions
Automated machine learning provided validated models that can be readily implemented in future deployment cohorts in the Danish Defense with the aim of targeting postdeployment support interventions to those at highest risk for developing PTSD, provided the cohorts are deployed on similar missions.
Two Decades of Research Using Taiwan’s National Health Insurance Claims Data: Bibliometric and Text Mining Analysis on PubMed
Authors: Sung Sheng-Feng , Hsieh Cheng-Yang , Hu Ya-Han 
Published: April 2020

BackgroundStudies using Taiwan’s National Health Insurance (NHI) claims data have expanded rapidly both in quantity and quality during the first decade following the first study published in 2000. However, some of these studies were criticized for being merely data-dredging studies rather than hypothesis-driven. In addition, the use of claims data without the explicit authorization from individual patients has incurred litigation.ObjectiveThis study aimed to investigate whether the research output during the second decade after the release of the NHI claims database continues growing, to explore how the emergence of open access mega journals (OAMJs) and lawsuit against the use of this database affect the research topics and publication volume and to discuss the underlying reasons.MethodsPubMed was used to locate publications based on NHI claims data between 1996 and 2017. Concept extraction using MetaMap was employed to mine research topics from article titles. Research trends were analyzed from various aspects, including publication amount, journals, research topics and types, and cooperation between authors.ResultsA total of 4473 articles were identified. A rapid growth in publications was witnessed from 2000 to 2015, followed by a plateau. Diabetes, stroke, and dementia were the top 3 most popular research topics whereas statin therapy, metformin, and Chinese herbal medicine were the most investigated interventions. Approximately one-third of the articles were published in open access journals. Studies with two or more medical conditions, but without any intervention, were the most common study type. Studies of this type tended to be contributed by prolific authors and published in OAMJs.ConclusionsThe growth in publication volume during the second decade after the release of the NHI claims database was different from that during the first decade. OAMJs appeared to provide fertile soil for the rapid growth of research based on NHI claims data, in particular for those studies with two or medical conditions in the article title. A halt in the growth of publication volume was observed after the use of NHI claims data for research purposes had been restricted in response to legal controversy. More efforts are needed to improve the impact of knowledge gained from NHI claims data on medical decisions and policy making.
Disease burden of schizophrenia patients visiting a Chinese regional mental health centre
Authors: Zhong Qiuping , Tan Yuxi , Chen Wendong , Huang Huiqing , Huang Jing , Li Sujuan , Teng Ziwei , Shen Manjun , Wu Chujun , Wang Lu , Cao Song , Chen Jindong , Wu Haishan , Tang Hui 
Published: April 2020

Aim & methods:
A decision-analytic model was constructed to simulate a real-world cohort of Chinese patients visiting a Chinese regional mental health center for long-term health outcomes and direct medical costs.
Results:
When compared with age and gender-matched general population, the Chinese patients with schizophrenia were associated with reduced overall survival by 20.6 years (27.6 vs 48.2 years) and reduced quality-adjusted life years (QALY) by 18.4 QALY (18.4 vs 36.8 QALY), respectively, and increased lifetime direct medical costs by about three-times (US$84,324 vs 33,387 as of 31 December 2017) on average.
Conclusion:
The burden of schizophrenia was mainly driven by the mortality associated with relapsed schizophrenia and direct medical costs for schizophrenia in local mental health rehabilitation institutes.
Analysis of TSP: Simulated Annealing and Genetic Algorithm Approaches
Authors: BOTSALI Ahmet Reha , ALAYKIRAN Kemal 
Published: April 2020

This paper analyzes the performance of the popular heuristic methods ‘Simulated Annealing (SA)’ and ‘Genetic Algorithm (GA)’ on the symmetric TSP. TSP is a well-known combinatorial optimization problem in NP-complete class. NP-completeness of TSP originates many specific approximation algorithms to find optimal or near optimal solutions in a reasonable time. On the other hand, both SA and GA are general purpose heuristic methods that are applicable to almost every kind of problem whose solution lies inside a search space. The performance of SA and GA depends on many factors such as the nature of the problem, design of the algorithm, parameter values, etc. In this paper, a GA and an SA algorithm are given and their performance with re-spect to several factors is analyzed. The algorithms are tested on some benchmark problems (TSPLIB) which are obtainable via Internet from http://elib.zib.de/pub/mp-testdata/tsp/tsplib/tsp/index.html.
IMPACTS OF CORRUPTION ON INNOVATION AND WELL-BEING ON COUNTRIES REPRESENTED IN THE ICIM BY OECD MEMBERS
Authors: Magalhães Kallita Ester , Portes Jerônimo Henrique , Domenech Arthur Molino , Junqueira Luciano A. Prates 
Published: April 2020

Corruption is a treat to well-being, as showed in this article. The study compares statistically the OECD member states and cross check with the countries where the universities that contribute to the ICIM (International Conference on Innovation and Management) are located. A statistically analyses of 39 countries using 13 selected indicators, some from the UNSDGs and others from the Observatory ORIBER 2 ,was applied seeking areas of the ICIM Proceedings that may be developing and deepening their research in order to contribute for a better global future.
THE INFLUENCE OF GLOBALIZATION IN BRAZILIAN HIGHER EDUCATION
Authors: Carvalho Alexey 
Published: April 2020

The purpose of this paper is to bring to reflection the main influences of globalization in Brazilian higher education has occurred in the last two decades. A critical analysis of the relevant literature was made, addressing the main international organizations such as the World Bank (WB) and the Organization for Economic Cooperation and Development (OECD), as well as its main guidelines for the education. Among the aspects analyzed, it is possible to verify a convergence of the guidelines of these organizations about the importance of Higher Education for economic development and the need to link the use of public resources to quality.
Intestinal echinococcosis in a dog from Missouri
Authors: Kuroki Keiichi , Morishima Yasuyuki , Neil Julie , Beerntsen Brenda T. , Matsumoto Jun , Stich Roger W. 
Published: April 2020

Abstract

CASE DESCRIPTION
A 17-week-old 14.4-kg (31.7-lb) female German Shepherd Dog from Missouri with a history of multiple intermittent episodes of vomiting and diarrhea underwent exploratory celiotomy.

CLINICAL FINDINGS
At the time of surgery, the dog was bright, alert, and responsive, with a tender abdomen and palpable mesenteric lymph nodes. Hematologic data revealed mild leukocytosis, mild hypoproteinemia, and mild hypoalbuminemia. Moderate petechiation of the jejunal serosa and prominent mesenteric lymph nodes, but no palpable obstructions, were found during surgery. Jejunal and lymph node biopsies were performed; histologic examination revealed multiple segments of adult cestodes up to 700 μm long in the jejunum. Segments had a scolex and contained approximately 30- to 35-μm-diameter ova, morphologically compatible with Echinococcus spp. Fecal flotation revealed numerous proglottids and ova similar to those recognized histologically. Results of PCR assays confirmed Echinococcus multilocularis of E4 haplotype (a European strain).

TREATMENT AND OUTCOME
Praziquantel (5 mg/kg [2.3 mg/lb], SC, once) was administered after surgery; treatments after hospital discharge included praziquantel (10 mg/kg [4.5 mg/lb], PO, once). No proglottids or ova were observed by fecal flotation after the treatments. The dog remained healthy without gastrointestinal signs 1 year later.

CLINICAL RELEVANCE
The dog of this report had no travel history outside the state of Missouri. To the authors’ knowledge, this is the first report of intestinal E multilocularis infection in a pet dog in the contiguous United States and first detection of a European strain of E multilocularis in this country. Findings suggested possible establishment of a European strain of this zoonotic pathogen in the contiguous United States.
Strategies for mitigating burnout among early career doctors in Nigeria: lessons learnt from the qualitative CHARTING study
Authors: Adebayo Oladimeji , Kanmodi Kehinde , Olaopa Olusegun , Fagbule Omotayo Francis , Adufe Iyanu , Adebayo Adeniyi Makinde , Oduyemi Ibiyemi , Amoo Abimbola , Omololu Ayanfe , Igbokwe Martin , Babalola Rereloluwa , Oiwoh Sebastine , Grillo Elizabeth , Buowari Dabota Yvonne , Egbuchulem Ifeanyichukwu , Umar Wasinda Francis , Ogunsuji Oluwaseyi , Ibrahim Yahya Abdulmajid 
Published: April 2020

Abstract

Background
Early career doctors (ECDs) are faced with many challenges due to their transition from undergraduate medical/dental studentship to being postgraduate doctors and being in an early phase of their career. The specific factors that affect ECDs in their careers and endeavors at the workplace range from poor remuneration, particularly in developing countries, to psychosocial problems (such as burnout [BO] syndrome). There is a dearth of information on BO among ECDs in Nigeria. This qualitative study aims to explore the opinions of ECDs in Nigeria on the causal/predisposing factors of BO, effects of BO, and strategies for mitigating BO among ECDs in Nigeria.

Method
Using purposive sampling method, two sessions of focus group discussions (FGDs) involving 14 ECDs (key informants) holding key leadership positions and who were delegates of other ECDs in Nigeria were conducted to explore their experiences on psychological issues among ECDs. Data collected were transcribed and analyzed thematically.

Results
BO is an issue of serious concern among ECDs in Nigeria. The causes of BO are diverse, some of which include low staff strength, prolonged work hours, wrong counseling, lack of job description and specification, and abuse of powers by trainers. In order to mitigate the issue of BO among ECDs, the respondents recommended that work policy review, medical workforce strengthening, stakeholder dialog on ECDs’ welfare, regular psychological review of ECDs, and provision of free yearly medicals need to be looked into. Conclusion: Our findings revealed that the participants considered BO issues among ECDs to be common, and it affected their performance and the overall quality of care in Nigeria health system. Based on our findings, there is an urgent need to mitigate the problem of emotional exhaustion among ECDs in Nigeria.
Are children safe from complications of leprosy? A study from North Kerala
Authors: Premachandran Mekha , George Nikhil , Binitha T. , Nandakumar Veena , Jishna Pulpadathil , Sasidharanpillai Sarita , Devi Keerankulangara , Samad K. Abdul , George Biju , Mann Pardeep 
Published: April 2020

Objectives:The aims of the study were (1) to document the demography and clinical profile of patients with leprosy at a tertiary referral center from 2009 to 2018. (2) To compare the disease manifestation in children aged 12 years/below and the same in patients above 12 years.Materials and Methods:Case records of all patients diagnosed to have leprosy as per the World Health Organization cardinal criteria at our tertiary referral center from 2009 to 2018 were included in this study. The findings recorded in those aged 12 years/below were compared with those above 12 years using Pearson’s Chi- square test.Results:A total of 705 patients who attended our institution during the 10 year period were diagnosed to have leprosy. Six hundred and sixty-four (94.2%) were above 12 years of age and 41 patients (5.8%) were aged 12 years or below. Lepromatous spectrum cases, pure neuritic cases, Grade 2 disability, and lepra reactions were not documented in any of the patients aged 12 years or below which were contrary to the observations in those above 12 years. The differences were found to be statistically significant.Limitations:Retrospective design and small number of childhood cases were the main limitations of the study.Conclusion:Clinical presentation of leprosy in children differs from that in adults. Detection of disease in childhood offers an opportunity to cure the disease with less risk of developing some of the important disease and therapy-related complications.
Decompositions of Complete Multigraphs into Cyclic Designs
Authors: Alqadri Mowafaq , Ibrahim Haslinda , Karim Sharmila 
Published: April 2020

Let Â and Â be positive integer, Â denote a complete multigraph. A decomposition of a graph Â is a set of subgraphs of Â whose edge sets partition the edge set of . The aim of this paper, is to decompose a complete multigraph Â into cyclic -cycle system according to specified conditions. As the main consequence, construction of decomposition of Â into cyclic Hamiltonian wheel system, where , is also given. The difference set method is used to construct the desired designs.
Concerns-Based Reverse Engineering for Partial Software Architecture Visualization
Authors: Alamin M Hind , Ammar Hany H 
Published: April 2020

Recently, reverse engineering (RE) is becoming one of the essential engineering trends for software evolution and maintenance. RE is used to support the process of analyzing and recapturing the design information in legacy systems or complex systems during the maintenance phase. The major problem stakeholders might face in understanding the architecture of existing software systems is that the knowledge of software architecture information is difficult to obtain because of the size of the system, and the existing architecture document often is missing or does not match the current implementation of the source code. Therefore, much more effort and time are needed from multiple stakeholders such as developers, maintainers and architects for obtaining and re-documenting and visualizing the architecture of a target system from its source code files. The current works is mainly focused on the developer viewpoint. In this paper, we present a RE methodology for visualizing architectural information for multiple stakeholders and viewpoints based on applying the RE process on specific parts of the source code. The process is driven by eliciting stakeholdersâ€™ concerns on specific architectural viewpoints to obtain and visualize architectural information related these concerns. Our contributions are three fold: 1- The REÂ methodology is based on the IEEE 1471 standardÂ for architectural description and supports concerns of stakeholderÂ including the end-user and maintainer; 2- It supports the visualization of a particular part of the target system by providing a visual model of the architecturalÂ representationÂ which highlights the main components needed to execute specific functionality of the target system, 3- The methodology also uses architecture styles to organize the visual architecture information. We illustrate the methodology using a case study of a legacy web application system.
Rancang Bangun Sistem Aplikasi Absensi dan Penilaian Prestasi Kerja pada Remaja Center
Authors: Subhi Imam Dwi , Irfansyah Puput 
Published: April 2020

Remaja salah satu komponen bangsa dalam pembangunan sosial, politik, dan budaya sebuah negara dalam melakukan pendataan maupun membuat laporan Remaja Center masih menggunakan buku besar yang dikhawatirkan dapat dengan mudah untuk kehilangan suatu data yang sudah dibukukan. Pendataan absensi yang telah terkomputerisasi sangat diperlukan untuk meningkatkan serta mempertahankan tingkat kinerja yang bermutu, karena dapat dijadikan sebagai alatbantu untuk melakukan aktivitas misalnya dalam pengolahan data, Pembuatan laporan dan penyimpanan data dimana menghasilkan suatu informasi yang cepat, tepat dan akurat. Tujuan penelitian yang diharapkan dalam Rancang Bangun Sistem Aplikasi Absensi dan Penilaian Prestasi Kerja pada Remaja Center adalah merancang Sistem Aplikasi Absensi dan Penilaian Prestasi Kerja pada Remaja Center yang efektif dan efisien agar memperoleh data yang akurat, tepat dan cepat, penyimpanan data secara aman, sehingga data yang diberikan secara relevan dan akurat sehingga data yang dimasukkan akan mudah diolah menjadi sebuah laporan. Pada Penelitian ini, peneliti menggunakan metode Grounded Research yaitu sebuah metodologi riset atau bias juga dipahami sebagai sebuah pendekatan penelitian dimana data lapangan menjadi sumber formulasi teori. Dengan adanya sistem aplikasi absensi dan penilaian prestasi kerja ini, maka masalah pendataan karyawan dapat dikontrol dengan lebih mudah, karena segala bentuk proses pendataan dihubungkan dengan database yang saling beintegrasi. Dan Dengan adanya sistem aplikasi absensi dan penilaian prestasi kerja ini juga dapat memudahkan dalam mendata absensi, dan mempermudah melakukan penilaian prestasi kerja karyawan. Kata Kunci: Sistem Informasi, Absensi, Penilaian
Orbital Compression Syndrome in a Child with Sickle Cell Anaemia: A Case Report And Review of Literature
Authors: Panda Prateek Kumar 
Published: April 2020

Vaso-occlusive crises in sickle cell disease commonly involve bone marrow of the long bones and vertebrae. Involvement of bones with less marrow space, including the bones of the orbit, is reported rarely in the literature. The present case is a six year old boy, a known case of sickle cell disease, who presented with acute onset right upper and lower eyelid swelling, restriction of extraocular movement and pain. USG orbit showed a retro-orbital haemorrhage compressing on the orbit, probably due to orbital bone infarction. The child was managed successfully with red blood cell transfusion and intravenous antibiotics, without steroids and surgical intervention. This report highlights the importance of maintaining a high index of suspicion in patients with known sickle cell disease presenting with pain, orbital swelling and restriction of ocular movement. Timely red blood cell transfusion only may be sufficient for uneventful recovery, without steroids or surgical intervention. Expedient diagnosis of orbital compression syndrome in children with sickle cell disease is crucial because this is a potentially sight-threatening entity.
The Development and Validation of Questionnaire on Autism Spectrum Disorders and its Association With Plastic-Based Food Contact Materials
Authors: Nor Zaleha Md , Isa Zaleha Md , Yusof Siti Norbayah , Ghazi Hasanain Faisal , Jaafar Mohd. Hasni 
Published: April 2020

Introduction: Autism is a neuropsychiatric disorder. Multiple factors have been identified as causes of autism spectrum disorder. Many studies indicated genetic as the main risk factor, but environmental risk factors are also seen as contributing factors. Exposure to environmental pollutants such as endocrine disrupting chemicals (EDCs) can occur as early as in the mother’s womb. The main concern of EDCs in food packaging are Bisphenol A (BPA) and phthalates. The objectives of this study are to develop and validate a questionnaire for the assessment of habitual usage of plastic- based food contact materials (FCM) as a proxy for exposure to this group of EDCs.
Material and Methods: The questionnaire developed by organising a focus group discussion among experts. An interview-guided pilot study was then done to 250 respondents for construct validation process. In the validation process, test-retest study for reliability, Cronbach alpha for internal consistency, exploratory factor analysis and confirmatory factor analysis were done.
Results: The questionnaire achieved kappa value ranged between 0.800 to 0.900 for knowledge, 0.610 to 0.815 for perception and 0.607 to 1.000 for self-care product section. Cronbach alpha value ranged between 0.600 to 0.780.
Conclusions: Exploratory and confirmatory factor analysis approved the final model for phase one consisting of four domains with total of 13 items and final model for phase two consists of three domains with total of nine items.