bluuebunny/crossref_metadata_2025_split huggingface dataset:
The right internal mammary artery and the great saphenous vein used for left anterior descending artery revascularization in patients whose left internal mammal artery cannot be used: a study based on transit-time flow measurement.
Authors: Zhang Guodong , Chen Yu , Chen Shenglong , Liu Gang , Zhao Zhou 
Published: March 2020

Abstract
Background: Owing to the high patency, the use of the left internal mammary artery (LIMA) for left anterior descending artery (LAD) grafting has been a cornerstone of coronary artery bypass graft surgery (CABG). However, for some patients whose LIMA cannot be used, surgeons have to choose the other conduit materials to revascularize the LAD. The purpose of this study was to explore the difference of different conduit materials used for LAD in the parameters measured by transit-time flow measurement (TTFM) and the early graft patency detected by computed tomography angiography.Methods: We retrospectively collected the data of 410 patients who undergoing isolated primary OPCAB with intraoperative TTFM data. According to the strategy of the left descending artery (LAD) revascularization, 410 patients were assigned to three groups: a left internal mammal artery (LIMA)group(n=333), a right IMA group (n=34) and a great saphenous vein (SVG) group (n=43). The baseline and perioperative blood parameters were compared for the three groups, as well as the early graft patency rates. Results: Compared with the LIMA-LAD group, the SVG-LAD group had a significantly higher mean graft flow volume(37.15±23.29vs29.71±20.94ml/min, P=0.036),however, a lower pulsatility index (2.07±0.62vs 2.65±1.01,P＜0.001).There was no significant difference between the two groups in DF(P＞0.05).Compared with the RIMA-LAD group, the SVG-LAD group just had a lower pulsatility index(2.07±0.62vs 2.56±0.96,P=0.029).However, there was no significant difference between the two groups in MGF and DF(P＞0.05).Compared with the LIMA-LAD group, the RIMA-LAD group had a bit lower DF(70.76±11.87vs74.06±7.09,P=0.018),while there was no difference in MGF and PI between the two groups(P＞0.05). The patency rate of the LIMA-LAD group was 98.72% (309/313), the RIMA-LAD group was 97.06% (33/34), and the SVG-LAD group was 100%. There was no difference among the three groups in patency rate(P=0.405).Conclusions: We conclude that in patients whose LIMA cannot be used，the in-suit RIMA and the SVG are comparable and even better than the LIMA in the blood flow parameters measured by TTFM. In our study，the early patency before discharge of RIMA-LAD and SVG-LAD are comparable with the LIMA-LAD.
Efficacy of Attachment-Based Family Therapy compared to Treatment as Usual for Depressed Adolescents in Community Mental Health Clinics
Authors: Waraan Luxsiya , Rognli Erling W. , Czajkowski Nikolai Olavi , Aalberg Marianne , Mehlum Lars 
Published: March 2020

Abstract
Background: Major Depressive Disorder (MDD) is a disabling mood disorder, profoundly affecting a large number of adolescent’s quality of life. To date, no obvious treatment of choice for MDD in adolescents is available and progress in the treatment of depressed adolescents will have important public health implications. Attachment-Based Family Therapy (ABFT), as the only empirically supported family therapy model designed to treat adolescent depression, aims to repair interpersonal ruptures and rebuild an emotionally protective parent-child relationship. Objective: To study the efficacy of ABFT compared with Treatment as Usual (TAU) delivered within child- and adolescent mental health services (CAMHS) to adolescents with MDD. Method: Sixty adolescents, aged 13-18 years, with MDD referred to two CAMHS were randomized to receive 16 weeks of ABFT or TAU. ABFT consisted of weekly therapy sessions (family/individual or both) according to the treatment manual. TAU was not monitored. Primary outcomes were clinician-rated (Hamilton Depression Scale, HAMD) and self-reported (Beck Depression Inventory-II, BDI-II) depressive symptoms assessed at baseline and post-treatment by blinded evaluators for HAMD and at baseline, and after 4, 6, 8, 10,12, 14, and 16 weeks for BDI-II. Analyses were performed according to intent-to-treat principles. Results: At post-treatment, clinician-rated remission rates on the HAMD (5 % in ABFT and 3.33% in TAU, p =1, OR=1.54, Fisher’s exact test) and self-reported symptoms of depression on the BDI-II did not differ significantly between groups ( X 2 [2, N = 60] =0.06 , p = 0.97). In both treatment groups participants reported significantly reduced depressive symptoms, but the majority of adolescents were still in the clinical range after 16 weeks of treatment. Conclusion: In this sample of adolescents treated for MDD in community mental health clinics, ABFT was not associated with more favorable outcomes than TAU in terms of remission rates on clinician rated and self-reported depressive symptoms. Remission and response rates were low in both groups, suggesting a need for continued improvement of the treatment methods. Trial Registration: Clinicaltrials.gov identifier: NCT01830088 https://clinicaltrials.gov/ct2/show/NCT01830088?term=Villab%C3%B8&draw=2&rank=1 Date of registration: April 12, 2013 Keywords: Depression, Adolescents, Attachment Based Family Therapy, Efficacy trial
Effective Stereo Matching with Segment-based Cost Aggregation and Dual-path Refinement
Authors: Huang Chih-Shuan , Huang Ya-Han , Chan Din-Yuen , Yang Jar-Ferr 
Published: March 2020

Abstract
Stereo matching is one of the most important topics in computer vision and aims at generating precise depth maps for various applications. The main challenge of stereo matching is to suppress inevitable errors occurring in smooth, occluded and discontinuous regions. To solve the aforementioned problems, in this paper, the proposed robust stereo matching system by using segment-based superpixels and magapixels to design adaptive stereo matching computation and dual-path refinement. After determination for edge and smooth regions and selection of matching cost, we suggest the segment–based adaptive support weights in cost aggregation instead of color similarity and spatial proximity only. The proposed dual-path depth refinements utilize the cross-based support region by referring texture features to correct the inaccurate disparities with iterative procedures to improve the depth maps for shape reserving. Specially for left-most and right most regions, the segment-based refinement can greatly improve the mismatched disparity holes. The experimental results demonstrate that the proposed system can obtain higher accurate depth maps compared with the conventional methods.
The possible association of steroids with fluid accumulation in critically ill patients – a case of a potential bias
Authors: Frenkel Amit , Abuhasira Ran , Bichovsky Yoav , Bukhin Anton , Novack Victor , Brotfain Evgeni , Zlotnik Alexander , Klein Moti 
Published: March 2020

Abstract
Background: Glucocorticoids (GCS) are commonly administered to critically ill patients. Due to their mineralocorticoid effect, GCS might have a substantial influence on a positive fluid balance. We assessed the association between glucocorticoids (GCS) therapy and fluid balance in critically ill patients with sepsis.Methods: This is a retrospective study of patients with sepsis hospitalized during 2006-2018 in a general intensive care unit (ICU) at a 1100-bed tertiary medical center.Results – We considered two definitions of exposure: daily exposure to GCS and GCS treatment at any time in the ICU. Of 945 patients with a diagnosis of sepsis, 375 were treated with GCS at any time and 570 were not. We applied four regression models to assess the association between GCS treatment and fluid balance; in our first model, fluid balance did not differ during days with GCS treatment, between patients who were and were not treated with GCS in the ICU (coefficient estimate 79.5 (-55.4 to 214.4), p=0.25). In our second model, daily fluid balance was increased by 139.8 ml (10.8 to 268.9; p=0.03) in patients who were ever treated with GCS during their ICU stay compared to untreated patients. In the third model, which included only patients treated with GCS during their ICU stay, GCS treatment days were not associated with daily fluid balance (coefficient estimate -190.6 (-485.1 to 103.9), p-value=0.21). In the last model, on "steroid free days", patients who received GCS treatment during their ICU stay had a positive fluid balance compared to those who were never treated with steroids (coefficient estimate 157.7 (-24.6 to 340.1), p-value=0.09).Conclusions – Despite their known mineralocorticoid activity, GCS themselves appear not to contribute substantially to fluid retention. The findings highlight the importance of a clear definition of exposure.
High Hb F level is associated with the risk of cerebral vasculopathy in a cohort of sickle cell children in Mayotte.
Authors: Elenga Narcisse , CHAMOUINE Abdourahim , SAANDI Thoueiba , MUSZLAK Mathias , LARMARAUD Juliette , LAMBRECHT Laurent , POISSON Jean , BALICCHI Julien , PISSARD Serge 
Published: March 2020

Abstract
Background Understanding the genetics underlying the heritable subphenotypes of sickle cell anemia, specific to each population, would be prognostically useful and could inform personalized therapeutics. Methods This study aimed to describe the genetic modulators of sickle cell disease in a cohort of pediatric patients followed in Mayotte between 2007 and 2017. Results We included 190 children with 72% SS, 16% Sβ0-thalassemia and 12% Sβ+ thalassemia. The mean age was 9.5 (1.6-23.4) years; 10% of patients were lost to follow up. The Bantu haplotype was associated with an increase in hospitalizations and transfusions. The alpha-thalassemic mutation was associated with a decrease of hemolysis biological parameters (anemia, reticulocytes), and less cerebral vasculopathy. The SNPs BCL11A rs4671393, BCL11A rs11886868, BCL11A rs1427407 and HMIP rs9399137 were associated with the group of children with HbF> 10%. The survival analysis without occurrence of cerebral vasculopathy showed that the group of patients with HbF> 10% presented a significant risk of early onset of cerebral vasculopathy. Conclusions Although the sub-phenotypes were difficult to clearly distinguish in our study, a genotype-sub-phenotype link is emerging.
The experience of using ocrelizumab in routine practice
Authors: Popova E. V. , Ryabov S. A. 
Published: March 2020

Introduction. The routine use of highly effective drugs that alter the course of multiple sclerosis requires careful patient selection in order to minimize the risks of possible adverse events. At present, drugs modifying the course of multiple sclerosis have been registered with different mechanisms of action. This makes it possible to implement individual selection of therapy taking into account the multifaceted pathogenesis of the disease. However, the presence of a burdened somatic anamnesis in the patient may significantly limit the choice of drugs by the attending physician. Aim: to gain experience in using ocrelizumab to treat patients with multiple sclerosis. Materials and methods. From 2018 ocrelizumab therapy was started in 52 MS patients: 32 patients with recurrent multiple sclerosis (MS) (23 with remitting multiple sclerosis (RMS) and 9 with secondary progressive MS with exacerbations) and 20 patients with primary progressive multiple sclerosis (PPMS). The drug was administered intravenously in drops with infusion in a dose of 600 mg every 6 months in a daytime regimen with an approved protocol of premedication and symptomatic therapy to prevent possible risks of adverse events. The initial dose was divided into 2 infusions of 300 mg at intervals of 2 weeks [5]. Before each infusion, detailed clinical blood analysis, biochemical blood tests, serological tests (HIV, hepatitis B and C, syphilis), and screening for tuberculosis (once a year) were necessarily repeated.The results. The achieved results clearly demonstrate high efficacy of ocrelizumab in the form of reduction of exacerbations frequency, disease activity according to MRI data and slower progression, which is compared with the data from previous OPERA I, OPERA II and ORATORIO clinical trials. After analysis of the data of dynamics of disability index according to EDSS scale there was observed stabilization in PPMS patients and a slight decrease in RMS patients. No exacerbations were registered in patients with RMS during the period of treatment, as well as no objective data on progression in patients with PPMS were noted.There is also good tolerance of therapy. However, the question remains as to how long the therapy should take into account the safety spectrum.
Enhancing stormwater sediment settling at detention pond inlets by a bottom grid structure (BGS)
Authors: Milovanović Ivan , Bareš Vojtěch , Hedström Annelie , Herrmann Inga , Picek Tomas , Marsalek Jiri , Viklander Maria 
Published: March 2020

Abstract
Stormwater sediments of various sizes and densities are recognised as one of the most important stormwater quality parameters that can be conventionally controlled by settling in detention ponds. The bottom grid structure (BGS) is an innovative concept proposed in this study to enhance removal of stormwater sediments entering ponds and reduce sediment resuspension. This concept was studied in a hydraulic scale model with the objective of elucidating the effects of the BGS geometry on stormwater sediment trapping. Towards this end, the BGS cell size and depth, and the cell cross-wall angle were varied for a range of flow rates, and the sediment trapping efficiency was measured in the model. The main value of the observed sediment trapping efficiencies, in the range from 13 to 55%, was a comparative assessment of various BGS designs. In general, larger cells (footprint 10 × 10 cm) were more effective than the smaller cells (5 × 5 cm), the cell depth exerted small influence on sediment trapping, and the cells with inclined cross-walls proved more effective in sediment trapping than the vertical cross-walls. However, the BGS with inclined cross-walls would be harder to maintain. Future studies should address an optimal cell design and testing in an actual stormwater pond.
Dry Sand Quality: The Case Study of a Touristic Beach from Rio de Janeiro, Brazil
Authors: Krepsky Natascha , Nunes Karine Peixoto , Paula Junior Luiz Affonso de , Lino Viviane Almeida de Andrade , Naveira e Silva Clarissa Araujo Costa , Brandão Iracema Prestes , Santos Fernanda Silva dos 
Published: March 2020

Coastal contamination became a growing public health concern. Enteric illness outbreaks, and the occurrence of dermatitis and mycoses during the summer season in leisure areas, were usually related to seawater pollution. Pathogenic microorganisms can reach coastal areas through sewage discharges, compromising marine water, and beach quality. Although sand transmission of enteric illness is still unclear, there is an expressed concern that sand may act as reservoirs or vectors for humans infection. In this context, the main hypotheses of this study were: (i) fecal coliforms density changes within beach compartments; (ii) dry sand is the most contaminated beach compartment; (ii) fecal coliforms densities are within international standard limits for sand. Therefore, this case study quantified and compared within three months total fecal bacteria (TC) and thermotolerant coliforms (TEC) densities in seawater, wet, and dry sand of a chosen touristic beach from Rio de Janeiro, Brazil. Furthermore, to contribute to coastal beach management, sand contamination data surveyed were compared with the standard limits ruling worldwide until April 2018 to check suitableness. Vermelha beach should be considered as a reference beach for sand monitoring in Brazil. Despite being a buffer zone from the MONA Pão Açucar conservation unit, it is subjected to intense touristic pressure. Even though, fecal bacteria densities quantified in Vermelha beach were within the standards of “excellent” quality sand and water according to current legislation/guidelines. However, dry sand was the most contaminated compartment, followed by seawater and wet sand. The bacterial density in dry sand was up to 4,600 times higher than wet sand. Except for Rio de Janeiro city, recreational guidelines for beach quality is exclusive for seawater contamination. There are no established parameters for recreational beach sand classification, only recommendations, including Portugal. Monitoring recreational beach dry sand is critical to reducing the risk of beachgoer exposure to pathogens.
Lithium-Protein Interactions: Analysis of Lithium-Containing Protein Crystal Structures Deposited in the Protein Data Bank
Authors: Carugo Oliviero 
Published: March 2020

Background:
Despite the fact that lithium is not a biologically essential metallic
element, its pharmacological properties are well known and human exposure to lithium is
increasingly possible because of its used in aerospace industry and in batteries.

Objective:
Lithium-protein interactions are therefore interesting and the surveys of the structures of
lithium-protein complexes is described in this paper.

Methods:
A high quality non-redundant set of lithium containing protein crystal structures was
extracted from the Protein Data Bank and the stereochemistry of the lithium first coordination
sphere was examined in detail.

Results:
Four main observations were reported: (i) lithium interacts preferably with oxygen atoms;
(ii) preferably with side-chain atoms; (iii) preferably with Asp or Glu carboxylates; (iv) the
coordination number tends to be four with stereochemical parameters similar to those observed in
small molecules containing lithium.

Conclusion:
Although structural information on lithium-protein, available from the Protein Data
Bank, is relatively scarce, these trends appears to be so clear that one may suppose that they will be
confirmed by further data that will join the Protein Data Bank in the future.
Network Pharmacology-based Investigation of the Underlying Mechanism of Panax notoginseng Treatment of Diabetic Retinopathy
Authors: Piao Chunli , Sun Zheyu , Jin De , Wang Han , Wu Xuemin , Zhang Naiwen , Lian Fengmei , Tong Xiaolin 
Published: March 2020

Background:
Panax notoginseng, a Chinese herbal medicine, has been widely used to
treat vascular diseases. Diabetic retinopathy (DR) is one of the complications of diabetic
microangiopathy. According to recent studies, the application of Panax notoginseng extract and
related Chinese patent medicine preparations can significantly improve DR. However, the
pharmacological mechanisms remain unclear. Therefore, the purpose of this study was to decipher
the potential mechanism of Panax notoginseng treatment of DR using network pharmacology.

Methods:
We evaluated and screened the active compounds of Panax notoginseng using the
Traditional Chinese Medicine Systems Pharmacology database and collected potential targets of
the compounds by target fishing. A multi-source database was also used to organize targets of DR.
The potential targets as the treatment of DR with Panax notoginseng were then obtained by
matching the compound targets with the DR targets. Using protein-protein interaction networks
and topological analysis, interactions between potential targets were identified. In addition, we also
performed gene ontology-biological process and pathway enrichment analysis for the potential
targets by using the Biological Information Annotation Database.

Results:
Eight active ingredients of Panax notoginseng and 31 potential targets for the treatment of
DR were identified. The screening and enrichment analysis revealed that the treatment of DR using
Panax notoginseng primarily involved 28 biological processes and 10 related pathways. Further
analyses indicated that angiogenesis, inflammatory reactions, and apoptosis may be the main
processes involved in the treatment of DR with Panax notoginseng. In addition, we determined that
the mechanism of intervention of Panax notoginseng in treating DR may involve five core targets,
VEGFA, MMP-9, MMP-2, FGF2, and COX-2.

Conclusion:
Panax notoginseng may treat diabetic retinopathy through the mechanism of network
pharmacological analysis. The underlying molecular mechanisms were closely related to the
intervention of angiogenesis, inflammation, and apoptosis with VEGFA, MMP-9, MMP-2, FGF2,
and COX-2 being possible targets.
Soy Protein Remnants Digested by Gastro-duodenal Proteases can Alter Microbial Interactions and Intestinal Cholesterol Absorption
Authors: Lee Juyoung , Yum Yujin , Kim Sunghee , Katimbwa Dorsilla Anono , Lim Jinkyu 
Published: March 2020

Background:
Although the food quality of soy protein is known to be as good as that of
animal proteins, some soybean proteins are not susceptible to digestion and remain undigested in
the intestine. We hypothesized that digestion-resistant soy proteins might interact with the intestinal
membrane, microbes, and metabolites, and change the intestinal physiology or the profile of the
gut microbiome.

Objective:
To identify the Protease-Resistant Soy Proteins (PRSPs) and their interaction with intestinal
membrane proteins by MS, and to assess the functions of PRSPs in the small intestine.

Methods:
Soy proteins were sequentially digested with pepsin and pancreatin, and the PRSPs were
identified by SDS-PAGE and MS. Intestinal cell membrane proteins interacting with PRSPs were
isolated by affinity purification and photo-affinity crosslinking, and identified using MS/MS. Inhibition
of cholesterol absorption to lipoprotein-depleted intestinal cells, CaCo-2, and hepatic cells,
HepG2, was measured in the presence and absence of PRSPs. FITC-conjugated Gram-positive,
Lactobacillus plantarum, and Gram-negative bacteria, Escherichia coli, were incubated with Ca-
Co-2 cells in the presence of PRSPs to investigate the regulation of bacterial cell binding to intestinal
epithelial cells by PRSPs.

Results:
MS/MS of PRSPs identified glycinin, β-conglycinin, trypsin inhibitors, lipoxygenase, and
sucrose-binding protein. MS analysis also identified the intestinal membrane proteins bound to PRSPs.
The functions of the identified interacting proteins included ion transportation, carbohydrate-
binding, cytoskeleton formation, hydrolysis, cell-cell junction formation, and cholesterol/steroid-
binding. In particular, apolipoprotein E, aminopeptidase N, and Niemann-Pick C1-like protein
1 are known to be involved in cholesterol absorption in the small intestine. The inhibition of
cholesterol absorption by CaCo-2 and HepG2 cells by PRSPs confirmed the MS results. Binding of
L. plantarum and E. coli to CaCo-2 cells was efficiently inhibited by PRSPs.

Conclusion:
PRSPs can interact with intestinal membrane proteins, and regulate cholesterol absorption
by intestinal epithelial cell and interactions of the gut microbiome. Soy protein in the intestine
acts as a nutrient, and triggers changes in intestinal functions by interacting with intestinal cells, microorganisms,
and nutrients. These findings will provide valuable new functional information
about the effects of soy proteins on human health.