bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategi Keberlanjutan Pengelolaan Sumber Daya Berbasis Komunitas dalam Program Tanggung Jawab Sosial Perusahaan
Authors: Larasati Zita Wahyu , Sunartiningsih Agnes 
Published: October 2020

This article explains the strategy of managing the community resources in corporate social responsibility programs. For instance, this research aims to enrich studies on community empowerment strategies trough exploration of community empowerment programs conducted by corporates. This research uses a qualitative research method. Also, primary data was collected through in-depth interviews with the Sumbersari Village Cattle Group Society members, the Terapan Village Banana Processing Group administrators, Petrokimia Corporate of Gresik program assistants, and Petrokimia Corporate of Gresik staff. Furthermore, the research findings show that the sustainability strategy adopted by Petrokimia Corporate of Gresik is different for each program. In its implementation, Petrokimia Corporate of Gresik concerns on the plan for community empowerment sustainability programs, primarily based on an investigation and analysis of the needs, potential, and problems in both villages. These are due to differences in needs, potential, and problems in the two empowerment programs. These differences indicate that each region has its uniqueness in terms of variations, resources, and local responsibilities. The sustainability strategy implemented in the Cattle Program is potential integration and product diversification, while in the Banana Processing Program is adopted by product diversification.Artikel ini menjelaskan strategi pengelolaan sumber daya masyarakat dalam program tanggung jawab sosial perusahaan. Untuk itu, artikel ini diharapkan dapat memperkaya kajian mengenai strategi pemberdayaan masyarakat melalui eksplorasi program-program pemberdayaan masyarakat yang dilakukan oleh perusahaan. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian kualitatif. Data primer dikumpulkan melalui wawancara mendalam kepada pengurus Paguyuban Kelompok Ternak Sapi Desa Sumbersari dan Kelompok Pengolahan Pisang Desa Terapan, tenaga pendamping program, dan staf Perusahaan Petrokimia Gresik. Studi ini menunjukan adanya perbedaan strategi keberlanjutan yang diterapkan oleh Perusahaan Petrokimia Gresik dalam Program Ternak Sapi Desa Sumbersari dan Program Pengolahan Pisang Desa Terapan. Hal ini dikarenakan adanya perbedaan kebutuhan, potensi, dan masalah dalam kedua program pemberdayaan tersebut. Perbedaan tersebut menunjukan bahwa setiap daerah memiliki kekhasnnya masing-masing dilihat dari variasi, sumber daya, dan tanggung jawab lokalnya. Strategi keberlanjutan yang diterapkan pada Program Ternak Sapi adalah integrasi potensi dan diversifikasi produk, sedangkan pada Program Pengolahan Pisang adalah diversifikasi produk.
On the experience of the urban landscape: A commentary on Siegfried Lenz’s "Von der Wirkung der Landschaft auf den Menschen"
Authors: Szczepański Piotr 
Published: October 2020

The aim of this paper is to characterize the relation between the urban landscape (the image of the city) and the subject. The landscape is understood here in two ways: as something alien, excluding, and hostile, but also as something that gains new features when in contact with the Other. For it can be said, paraphrasing Siegfried Lenz’s famous statement on the relation between man and landscape, that the city is being created through us. The relationship between the residents and the urban landscape has a reciprocal character, in which “I” places itself in relation to a certain “you.”
How new is the new biography? Some remarks on the misleading term’s past and present
Authors: Cymbrykiewicz Joanna 
Published: October 2020

The article discusses the issue of the so-called “new biography” by underscoring ambiguity of the term and presenting the different variants of “new biography” it encompasses. In order to do that, an introduction is made where the tenets of the classical biography are outlined. The inquiry focuses chiefly on England and the USA, although remarks are also made with respect to biographical writing in other countries. It appears that the term is contemporarily mainly associated with Lytton Strachey’s model of biography which, having been formulated in 1918, proved a breakthrough in life writing, since it operated with ironic detachment from the protagonist. Strachey perceived biography as an art and was determined to speak openly about all spheres of the biographee’s life. The article proves that although other attempts at creating a “new biography” were made after Strachey (by Leon Edel and Jo Burr Margadant), their newness is either derivative and supplementary to Strachey’s achievement, or advances a wholly new notion of biography, with the concept of multiplicity of the protagonist’s self. As the Stracheyan biographical model is almost a century old, one can assume that what is understood as “new biography” is not so new after all. In the meantime, though, biographical practice has taken a turn and a novelistic mode of writing, i.e. biofiction, has become the current paradigm. The author therefore suggests that the present-day understanding of “new biography” be reconsidered by recognizing biofiction as one of the figures of biographical “newness”.
Zika virus depletes neural stem cells and evades selective autophagy by suppressing the Fanconi anemia protein FANCC
Authors: Tiwari Shashi Kant , Dang Jason W , Lin Nianwei , Qin Yue , Wang Shaobo , Rana Tariq M 
Published: October 2020

AbstractZika virus (ZIKV) is an emerging flavivirus, which when passed through vertical transmission from mother to developing fetus can lead to developmental abnormalities, including microcephaly. While there is mounting evidence that suggests a causal relationship between ZIKV infection and microcephaly, the mechanisms by which ZIKV induces these changes remain to be elucidated. Here, we demonstrate that ZIKV infection of neural stems cells, both in vitro and in vivo, induces macroautophagy to enhance viral replication. At the same time, ZIKV downregulates a number of essential selective autophagy genes, including the Fanconi anemia (FA) pathway genes. Bioinformatics analyses indicate that the transcription factor E2F4 promotes FANCC expression and is downregulated upon ZIKV infection. Gain and loss of function assays indicate that FANCC is essential for selective autophagy and acts as a negative regulator of ZIKV replication. Finally, we show that Fancc KO mice have increased ZIKV infection and autophagy protein levels in various brain regions. Taken together, ZIKV downregulates FANCC to modulate the host antiviral response and simultaneously attenuate neuronal growth.
Legal, Social and Cultural Prerequisites for the Development of ADR Forms in Lithuania and Ukraine
Authors: Nekrošius Vytautas , Vėbraitė Vigita , Izarova Iryna , Prytyka Yurii 
Published: October 2020

Alternative Dispute Resolution (ADR) mechanisms include several procedures that allow parties to resolve their disputes out of court in a private forum, with the assistance of a qualified neutral intermediary of their choice. Arbitration and mediation are one of the most popular institutes of alternative dispute resolution. This article analyzes the legal, social, and cultural prerequisites for the development of the institutes of arbitration and mediation in Lithuania and Ukraine.
Relationship of background electroencephalogram with cognitive impairment in patients with alcohol dependence
Authors: Galkin Stanislav A. , Peshkovskaya Anastasiya G. , Roshchina Olga V. , Belokrylov Il’ya I. , Bokhan Nikolaj A. 
Published: October 2020

A significant number of studies have focused on the neurophysiological basis of cognitive dysfunction among individuals with neurological and psychiatric disorders, including alcoholism. However, the neural correlates of cognitive deficits in alcohol dependence are still not clear enough.
The purposeof the study: to identify the relationship of background electroencephalogram indicators with cognitive disorders in patients with alcohol dependence.
Material and methods.107patients with alcohol dependence aged 30 to 60years after detoxification were examined. The background electroencephalogram was recorded with closed eyes for 2min. The values of the absolute spectral power of theta, alpha and beta rhythms were analyzed. The study of the level of Executive functioning was conducted using the Go/Nogo test. The level of spatially working memory was evaluated using the Corsi Block-Tapping test.
Results.Data analysis revealed statistically significant correlations between the spectral power of the alpha rhythm in the occipital cortex and the number of errors per inhibitory signal (Nogo) in the Go/Nogo problem (r=0.287; p=0.025). There were also statistically significant correlations between the values of alpha-rhythm spectral power and working memory in the Corsi test in the parietal cortex (r=0.273; p=0.037), occipital cortex (r=0.316; p=0.015) and temporal cortex (r=0.359; p=0.005). There were no statistically significant correlations of beta and theta rhythms with the results of cognitive tests (p0.05).
Conclusion.Thus, all of the above results indicate that the background EEG indicators, in particular the spectral power of alpha activity, can with a certain probability indicate violations of cognitive functioning (inhibitory control and working memory) in patients with alcohol dependence.
Kronik İshalin Nadir Bir Sebebi: Eozinofilik Kolit
Authors: DAĞ Muhammed Sait 
Published: October 2020

Amaç: Eosinofilik kolit (EK) kronik ishalin nadir ancak hayat kalitesi üzerine uzun süreli olumsuz etkileri nedeniyle önemli bir sebebidir. Ülkemizden EK ile ilgili yayınlar sınırlı olup, bu yazıda kliniğimiz bu konudaki verilerinin paylaşılması amaçlanmıştır.
Gereç ve Yöntem: Çalışmaya Mayıs 2016 ve Haziran 2020 tarihleri arasında kronik ishal etyolojisi araştırılmak üzere kolonoskopi yapılan ve patolojik inceleme sonucu EK tanısı konan vakalar dahil edildi. Hastaların demografik özellikleri, klinik özellikleri, labaratuvar değerleri, kolonoskopik ve patolojik verileri retrospektif olarak incelendi.
Bulgular: Çalışmaya 22 erkek ve 14 kadın olmak üzere toplam 36 vaka dahil edildi. Erkeklerin yaş ortalaması 42.6 (23-67) ve kadınların yaş ortalaması 52.2 yıl (18-75) idi. Başlıca klinik başvuru sebepleri ishal, karın ağrısı ve rektal kanama idi. Tanı öncesi şikayet süresi ortalama 13,7 ay (2-48) ve tanı sonrası ortalama takip süresi 16.5 ay (2-49) idi. Periferik euzonofili 7/36 vakada saptandı. Tüm hastalara metilprednisolon 16-32 mg/gün dozunda verildi.
Tartışma ve sonuç: EK kronik ishalin hayat kalitesini etkileyen önemli bir sebebidir. Metilprednisolon tedavisi son derece etkili ve güvenlidir. Klinik şüphe ve kolonoskopik biyopsilerin histopatolojik incelenmesi tanı için en önemli faktörlerdir.
Application of Tracer-Based Workflow for Calibrating Reservoir Heterogeneity
Authors: Doorwar Shashvat , Purswani Prakash , Ambastha Anil , Jain Lokendra , Thach Sophany 
Published: October 2020

SummaryCapturing the correct reservoir heterogeneity in a geological model is critical for designing and accurately forecasting expected production benefits from improved/enhanced oil recovery processes. In simple terms, reservoir heterogeneity is often considered as a measure of statistical variation of static properties, such as porosity and permeability. The Lorenz coefficient and Dykstra-Parsons coefficient are two such measures of reservoir heterogeneity that account for these static effects. These measures are considered simplistic because the spatial distribution and arrangement of these properties is more critical for reservoir characterization than its statistical variation. The dynamic Lorenz coefficient is one such measure that accounts for the spatial distribution and arrangement of porosity and permeability. The dynamic Lorenz coefficient cannot be directly measured in the field but can be implicitly inferred from tracer data. This inferred heterogeneity will be influenced by the spatial distribution of static properties and can also be significantly influenced by multiphase flow effects, such as viscous fingering and gravity over/underride, which often arise from the differences in the viscosities and densities of the different phases involved. The dynamic Lorenz coefficient interpreted from a tracer test response lumps both static and multiphase (dynamic) effects into one measure of heterogeneity. During geological model construction, the dynamic Lorenz coefficient is also used to rank the model in terms of heterogeneity to select the most representative model. However, the geological models are ranked using fast single-phase/streamline simulations and are devoid of complications caused by adverse mobility or density effects. This creates a disconnect between the heterogeneity measures used to characterize a geological model and those available to characterize a reservoir. Thus, calibrating a geological model to field data is a laborious task.In this paper, we present a workflow that bridges this gap by decoupling the effect of adverse mobility to obtain an approximate measure of heterogeneity that can be cross-checked against the geological realizations to select the most representative model. The workflow developed in this paper is for inverted, seven-spot patterns and is mainly focused on water-wet reservoirs.
A multi-stakeholder approach to the co-production of the research agenda for medicines optimisation
Authors: Fellenor John , Britten Nicky , Courtenay Molly , Payne Rupert A , Valderas Jose , Denholm Rachel , Duncan Polly , McCahon Deborah , Tatnell Lynn , Fitzgerald Richard , Warmoth Krystal , Gillespie David , Turner Katrina , Watson Margaret 
Published: October 2020

Abstract
Background Up to 50% of medicines are not used as intended, resulting in poor health and economic outcomes. Medicines optimisation is ‘a person-centred approach to safe and effective medicines use, to ensure people obtain the best possible outcomes from their medicines’. The purpose of this exercise was to co-produce a prioritised research agenda for medicines optimisation using a multi-stakeholder (patient, researcher, public and health professionals) approach. Methods A three-stage, multiple method process was used including: generation of preliminary research questions (Stage 1) using a modified Nominal Group Technique; electronic consultation and ranking with a wider multi-stakeholder group (Stage 2); a face-to-face, one-day consensus meeting involving representatives from all stakeholder groups (Stage 3). Results In total, 92 research questions were identified during Stages 1 and 2 and ranked in order of priority during stage 3. Questions were categorised into four areas: ‘Patient Concerns’ [e.g. is there a shared decision (with patients) about using each medicine?], ‘Polypharmacy’ [e.g. how to design health services to cope with the challenge of multiple medicines use?], ‘Non-Medical Prescribing’ [e.g. how can the contribution of non-medical prescribers be optimised in primary care?], and ‘Deprescribing’ [e.g. what support is needed by prescribers to deprescribe?]. A significant number of the 92 questions were generated by Patient and Public Involvement representatives, which demonstrates the importance of including this stakeholder group when identifying research priorities. Conclusions A wide range of research questions was generated reflecting concerns which affect patients, practitioners, the health service, as well the ethical and philosophical aspects of the prescribing and deprescribing of medicines. These questions should be used to set future research agendas and funding commissions.
Anthropometric changes in children under 7 years old in Nanjing, China from 1995 to 2015
Authors: Chen Ling , Chen Ying , Dong Jing , Li Xi Ling , Yao Tian Hong , Li Yue , Tong Mei Ling , Zhang Min 
Published: October 2020

Abstract
Background: To date, there have been several reports about long-term changes in physical growth in children of different races around the world. However, limited studies on this change have been reported in Nanjing, China. We decided to assess long-term changes in body weight, length/height and head circumference in children (0-7 years old) in Nanjing over the past two decades from 1995 to 2015 and the relationship between socioeconomic development and the change of physical growth.Methods: The results for body weight, length/height and head circumference in 0-to 7-year-old children were obtained from three repeated cross-sectional surveys that were performed by using the same methods in the same urban and suburban areas of Nanjing in 1995, 2005 and 2015. The differences in mean values between urban and suburban boys and girls and the increases per decade were compared. Socioeconomic indicators were collected and analysed.Results: There was positive long-term growth in height and weight of children in Nanjing from 1995 to 2015, measurements increased 0.3-3.00 kg in weight and 1.0-3.8 cm in height for boys, 0.23-2.18 kg in weight and 1.3-3.6 cm in height for girls in urban areas (except children under 15 months), as well as 0.32-4.15 kg in weight and 1.1-7.4 cm in height for boys, 0.26-2.95 kg in weight and 1.2-6.3 cm in height for girls in suburban areas (except children under 8 months). Compared with the first decade, the changes of mean values in height and weight of urban children in the second decade were smaller. In contrast, the long-term change of suburban children still kept fast growth rate. Before 2.5 years old, negative increases in weight and height in urban children were observed. Urban-suburban difference of weight and height became smaller in 2015. The growth of head circumference from 1995 to 2015 underwent a small long-term change, especially of urban children. Conclusion: The increased long-term physical growth due to rapid social and economic development would disappear, and genetic potential might have been seen. In future, health strategies in Nanjing may focus on controlling rapid weight gain and preventing obesity.
Impact of exercise training on symptoms of depression, physical activity level and social participation in people living with HIV/AIDS: A systematic review and meta-analysis
Authors: Ibeneme Sam Chidi , Uwakwe Victor C , Myezwa Hellen , Irem Franklin Onyedinma , Ezenwankwo Fortune Elochukwu , Ajidahun Tunde Adedayo , Ezuma Amarachi Destiny , Okonkwo Uchenna Prosper , Fortwengel Gerhard 
Published: October 2020

Abstract
Background: Symptoms of depression are prevalent in people living with human immune deficiency virus/acquired immune deficiency syndrome (PLWHA), and worsened by lack of physical activity/exercises, leading to restriction in social participation/functioning. This raises the question: What is the extent to which physical exercise training affected symptoms of depression, physical activity level (PAL) and social participation in PLWHA compared to other forms of interventions, usual care, or no treatment controls? Objectives: To assess the impact of physical exercise training on symptoms of depression, PAL and social participation in PLWHA. Data sources: Eight databases were searched up to July 2020, according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) protocol. Study eligibility criteria: Only randomised controlled trials involving adults who were either on HAART/HAART-naïve and reported in the English language, were included. Data collection and analysis: Two independent reviewers determined the eligibility of the studies, extracted data, assessed their quality, and risk of bias using the Physiotherapy Evidence Database (PEDro) tool. Standardised mean difference (SMD) was used as summary statistics for the mean primary outcome (symptoms of depression) and secondary outcomes (PAL and social participation) since different measuring tools/units were used across the included studies. Summary estimates of effects were determined using a random-effects model (I2). Results: Thirteen studies met the inclusion criteria with 779 participants (n=596 participants on study completion) randomised into the study groups, comprising 378 males, 310 females and 91 participants with undisclosed gender, and with an age range of 18-86 years. Across the studies, aerobic or aerobic plus resistance exercises were performed 2-3 times/week, at 40-60 minutes/session, and for between 6-24 weeks, and the risk of bias varied from high to low. Comparing the intervention to control groups showed significant difference in the symptoms of depression (SMD=-0.74, 95% confidence interval (CI)=-1.01,-0.48,p=<0.0002;I2=47%;5studies; 205participants) unlike PAL (SMD=0.98,95%CI=-0.25,2.17,p=0.11;I2=82%;2studies;62 participants) and social participation (SMD=0.04,95%CI=-0.65,0.73,p=0.91;I2=90%; 6 studies; 373 participants).Conclusion: Physical exercise training could have an antidepressant-like effect in PLWHA but did not affect their PAL and social participation. However, the high heterogeneity in the included studies, imply that adequately powered RCTs with clinical/methodological similarity are required in future studies.Registration number: INPLASY202040048
Quantifying the adhesive strength between the SARS-CoV-2 S-proteins and human receptor and its effect in therapeutics
Authors: Torre Mauricio Ponga de la 
Published: October 2020

Abstract
The binding affinity and adhesive strength between the spike (S) glycoproteins of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the human angiotensin-converting enzyme 2 (ACE2) receptor is computed using molecular dynamics (MD) simulations. The calculations indicate that the binding affinity is eRS= 12.6 +/- 1 kCal mol-1 with a maximum adhesive force of ~102 pN. Our analysis suggests that only 27 (13 in S-protein, 14 in ACE2) residues are active during the initial fusion process between the S-protein and ACE2 receptor. With these insights, we investigated the effect of possible therapeutics in the size and wrapping time of virus particles by reducing the binding energy. Our analysis indicates that this energy has to be reduced significantly, around 50\% or more, to block SARS-CoV-2 particles with radius in the order of R < 60 nm. Our study provides concise target residues and target binding energy reduction between S-proteins and receptors for the development of new therapeutics treatments for COVID-19 guided by computational design.