bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemanfaatan Pengguna Handpone Pada Masyarakat Desa Keleyan Kecamatan Socah Kabupaten Bangkalan
Authors: Dastiyana Nova 
Published: February 2020

Perkembanga teknologi jaman sekarang semakin berkembang dan semakin canggih, masyarakat jaman sekarang banyak yang menggunakan handpone sebagai alat komunikasi. Handpone adalah parangkat telekomunikasi elektronik yang mempunyai kemampuan dasar yang sama dengan handpone konvensional saluran tetap,namun dapat dibawa kemana –mana dan tidak perlu di sambungkan dengan jaringan telepon menggunakan kabel.handpone telah merubah perilaku komunikasi manusia dengan menembus ruang dan waktu. Banyak sekali dampak positif dan negative dari penggunaan handpone. Saat ini perkembangan tekhnologi handpone sangat berkembang pesat. Hampir semua orang mempunyai handpene sebagai alat komunikasi yang sangat mudah digunakan oleh masyarakat Indonesia, handpone ini tidak hanya sebagai alat komunikasi semata,tetapi saat ini dapat dimanfaatkan sebagai multimedia dan salah satunya dapat dimanfaatkan dalam dunia pendidikan. handphone memang berdampak positif terhadap masyarakat desa terutama dalam rangka menjaga tetap terjalinnya hubungan komunikasi dengan orang-orang teristimewa kerabat atau famili yang berada jauh di luar daerah. Namun di dalam kapasitas sebagai smartphone dengan berbagai fitur yang dimilikinya sebagai sumber informasi ternyata hal itu belum banyak diketahui pemanfaatannya oleh masyarakat desa.
Analisis Pengaruh Biaya Kompensasi Terhadap Motivasi Dan Kinerja Karyawan
Authors: Hasanah Uswatun 
Published: February 2020

Motivasi adalah dorongan yang timbul dalam diri seseorang secara sadar atau tidak sadar untuk melakukan suatu tindakan dengan tujuan tertentu, usaha yang menyebabkan seseorang atau kelompok tertentu tergerak melakukan sesuatu karena ingin mencapai tujuan yang dikehendakinya, kompensasi adalah segala bentuk sesuatu baik berupa uang, maupun barang fisik maupun nonfisik oleh perusahaan diberikan kepada karyawan yang bekerja di suatu perusahaan, sedangkan kinerja karyawan adalah merupakan suatu tingkatan pencapaian hasil kerja yang dicapai dalam melaksanakan tugas dan pekerjaan yang diberikan kepada pegawai dengan memperoleh imbalan prestasi tertentu.
Peran Religiusitas Dalam Memoderasi Perilaku Loyal Pasien Terhadap Suatu Rumah Sakit Islam Pku Surakarta
Authors: Haryanto Budhi , Panama Zulfikar Saad Octa , Cahyono Edi , Fenitra RA. 
Published: February 2020

Tujuan penelitian ini adalah untuk menerangkan peran religiusitas dalam memoderasi pengaruh kualitas layanan dan citra terhadap kepuasan pasien dan loyalitas. Sampel diambil secara acak sebanyak 250 orang pasien yang sedang menunggu antrian periksa di Rumah Sakit Islam PKU Muhamadiyah Surakarta. Data yang terkumpul dianalisis menggunakan Multi-Group SEM. Hasil uji menunjukkan bahwa kualitas layanan, citra rumah sakit dan kepuasan pasien mempengaruhi loyalitas, sedangkan kualitas layanan tidak berpengaruh terhadap loyalitas pasien. Ditemukan juga, bahwa religiusitas memeoderasi pengaruh kualitas layanan, citra rumah sakit dan kepuasan paseien terhadap loyalitas pasien. Hasil penelitian menunjukkan bahwa pasien dengan tingkat religiusitas yang tinggi dan rendah mempunyai perbedaan tingkat loyalitas di Rumah Sakit Islam PKU Muhamadiyah Surakarta. Hasil penelitian ini mendukung penelitian terdahulu dengan objek yang berbeda. Penelitian ini juga mengemukakan penemuan, implikasi teoritis di masa mendatang dan saran untuk penelitian selanjutnya.
Exploring Patient-Reported Barriers to Advance Care Planning in Family Practice
Authors: Author) Carrie Bernard(Former Corresponding , Tan Amy , Slaven Marissa , Elston Dawn , Heyland Daren K. , Author) Michelle Howard(New Corresponding 
Published: February 2020

Abstract
Background Although patient-centred care has become increasingly important across all medical specialties, when it comes to end of life care, research has shown that treatments ordered are not often concordant with people’s expressed preferences. Patient and family engagement in Advance Care Planning (ACP) in the primary care setting could improve the concordance between patients’ wishes and the healthcare received when patients cannot speak for themselves. The aim of this study was to better understand the barriers faced by older patients regarding talking to their family members and family physicians about ACP. Methods In this multi-site cross-sectional study, three free text questions regarding reasons patients found it difficult to discuss ACP with their families or their family physicians were part of a self-administered questionnaire about patients’ knowledge of and engagement in ACP. The questionnaire, which included closed ended questions followed by three probing open ended questions, was distributed in 20 family practices across 3 provinces in Canada. The free text responses were analyzed using thematic analysis and form the basis of this paper. Results 102 participants provided an analyzable response to the survey when asked why they haven’t talked to someone about ACP. 254 answered the question about talking to their physician and 340 answered the question about talking to family members. Eight distinct themes emerged from the free text response analysis: 1. They were too young for ACP; 2. The topic is too emotional; 3. The MD should be responsible for bringing up ACP 4. A fear of negatively impacting the patient-physician relationship; 5. Not enough time in appointments; 6. Concern about family dynamics; 7. It’s not a priority; and 8. A lack of knowledge about ACP. Conclusions Patients in our sample described many barriers to ACP discussions, including concerns about the effect these discussions may have on relationships with both family members and family physicians, and issues relating to patients’ knowledge and interpretation of the importance, responsibility for, or relevance of ACP itself. Family physicians may be uniquely placed to leverage the longitudinal, person- centred relationship they have with patients to mitigate some of these barriers.
A self-administered, artificial intelligence (AI) platform for cognitive assessment in multiple sclerosis (MS)
Authors: Khaligh-Razavi Seyed-Mahdi , Sadeghi Maryam , Khanbagi Mahdiyeh , Kalafatis Chris , Nabavi Seyed Massood 
Published: February 2020

Abstract
Background
Cognitive impairment is common in patients with MS. Accurate and repeatable measures of cognition have the potential to be used as markers of disease activity.
Methods
We developed a 5-minute computerized test to measure cognitive dysfunction in patients with MS. The proposed test – named the Integrated Cognitive Assessment (ICA) – is self-administered and language-independent. 91 MS patients and 83 healthy controls (HC) took part in Substudy 1, in which each participant took the ICA test and the Brief International Cognitive Assessment for MS (BICAMS). We assessed ICA’s test-retest reliability, its correlation with BICAMS, its sensitivity to discriminate patients with MS from the HC group, and its accuracy in detecting cognitive dysfunction. In Substudy 2, we recruited 48 MS patients, 38 of which had received an 8-week physical and cognitive rehabilitation programme and 10 MS patients who did not. We examined the association between the level of serum neurofilament light (NfL) in these patients and their ICA scores and SDMT scores pre- and post-rehabilitation.
Results
The ICA demonstrated excellent test-retest reliability (r=0.94), with no learning bias, and showed a high level of convergent validity with BICAMS. The ICA was sensitive in discriminating the MS patients from the HC group, and demonstrated high accuracy (AUC = 95%) in discriminating cognitively normal from cognitively impaired participants. Additionally, we found a strong association (r=-0.79) between ICA score and the level of NfL in MS patients before and after rehabilitation.
Conclusions
The ICA has the potential to be used as a digital marker of cognitive impairment and to monitor response to therapeutic interventions. In comparison to standard cognitive tools for MS, the ICA is shorter in duration, does not show a learning bias, and is independent of language.
A Cross-Sectional Study of Job Burnout, Psychological Attachment, and the Career Calling of Chinese Doctors
Authors: Zhang Shu'e , Wang Jinghui , Xie Fengzhe , Yin Dong , Shi Yu , Zhang Min , Yin Hongyan , Li Fujun , Yang Libin , Cao Depin , Sun Tao 
Published: February 2020

Abstract
Background: The main objectives of this study were as follows: (1) evaluate the prevalence of burnout syndrome among doctors, (2) establish associations with demographic factors in China, and (3) examine the mediating role of psychological attachment in the relationship between job burnout and career calling.
Methods:This cross-sectional survey was conducted by administering an online questionnaire in May 2016. The survey was performed across Thirty provinces. In total,A total of 3,016 Chinese doctors were selected as participants, of which 2,617 completed valid questionnaires (effective response rate: 86.77%).
Results: The overall prevalence of burnout symptoms among Chinese doctors was 85.79%. Little variance was reported for burnout symptoms according to age (Waldc2 = 6.843, P < 0.05, OR <1 ), professional title (Waldc2 = 13.110, P < 0.05, OR > 1), and daily working hours (Waldc 2= 7.226, P < 0.05, OR > 1). However, the burnout of Chinese doctors was found to be associated with psychological attachment (B = -0.6433, P < 0.0001) and career calling (B = 0.3653, P < 0.0001); furthermore, psychological attachment (B = 0.2350, P < 0.001) mediated the relationship between job burnout and career calling.
Conclusion: Burnout symptoms among Chinese doctors were prevalent and associated with age, professional title, and long working hours. Chinese doctors aged 20-30 experienced a much higher level of burnout symptoms. The longer hours doctors worked, the more likely they were at risk of burnout symptoms, especially among attending physicians. Doctors who endured high-level burnout tended to exhibit decreasing psychological attachment, which threatened their sense of career calling. Finally, this paper proposed related explanations for the function mechanisms based on both theoretical and practical perspectives.
Efficacy of a complex intervention comprising the guideline evidence-based health information and a training programme on the quality of health information: study protocol of a randomised controlled trial
Authors: Lühnen Julia , Berger-Höger Birte , Haastert Burkhard , Hinneburg Jana , Kasper Jürgen , Steckelberg Anke 
Published: February 2020

Abstract
Background Evidence-based health information (EBHI) is a prerequisite for informed and shared decision-making. The criteria for EBHI have been described comprehensively but the implementation in practice is still insufficient. The guideline evidence-based health information addresses providers of health information. Its goal is to improve the quality of health information. The evidence-based guideline emerged from the German Network for Evidence-based Medicine (DNEbM) and was published in February 2017. In addition, the competences of providers of health information were explored and a training programme was developed. Aim of this study is to evaluate the efficacy of a training programme addressing providers of health information to support the application of the guideline evidence-based health information. We expect the intervention to improve the quality of health information in comparison to provision of the guideline only. Methods The trial uses a superiority randomised control group design with ten months follow-up. 26 providers of health information (groups with up to ten members) will be enrolled to compare the intervention (guideline & training programme) with usual care (guideline publicly available). The 5-day training programme comprises an evidence-based medicine training module and a module to prepare the application of the guideline. The primary outcome parameter is the quality of the health information. Quality is operationalised as the extent of adherence to the guideline’s recommendations. Each provider will prepare a single health information informing a health-related decision on a freely chosen topic. The quality of this information will be rated using the Mapping Health Information Quality (MAPPinfo) checklist. An accompanying process evaluation will then be conducted. Discussion The study results will show whether the efficacy of the intervention justifies implementation of the training programme to enhance health information developers’ competences in evidence-based medicine and to ensure high quality EBHI in the long-term. Trial registration ISRCTN registry, registration number: ISRCTN96941060, Date: 7 March 2019, URL: http://www.isrctn.com/ISRCTN96941060
Enabling routine β-Thalassemia Prevention and Patient Management by Scalable, Combined Thalassemia and Hemochromatosis mutation analysis
Authors: Author) Ghazala Hashmi(Former Corresponding , Qidwai Asim , Fernandes Kristopher , Author) Michael Seul(New Corresponding 
Published: February 2020

Abstract
Background : Beta (β)-thalassemia is one of the most common inherited disorders worldwide, with high prevalence in the Mediterranean, the Middle East and South Asia. Over the past 40 years, many countries have implemented awareness and prevention campaigns that have greatly reduced the incidence of affected child births. In contrast, much remains to be done in South-Asia. Thus, for Pakistan, current estimates of the number of children born with thalassemia are at ~7,000 per annum, with no sign of improvement. Although there is good agreement that intermarriage of carriers is a principal source of the high prevalence of the disorder, effective tools for screening and diagnosis on which to base prevention programs are not readily available. Methods : Here, we present results for a novel “LeanSequencing” process to identify 18 β-thalassemia and related sickle cell anemia, and simultaneously a set of 3 hemochromatosis mutations in a multi-ethnic population of 274 pediatric and adolescent patients treated at Afzaal Memorial Thalassemia Foundation hospital in Karachi, Pakistan. Results : We found substantial differences in the abundance of disease-causing mutations among the principal ethnic groups in our cohort. We also found the hemochromatosis mutation H63D C > G in 61 (or 22.1%) of our patients including 7 (or 2.6%) homozygotes. Conclusions : To our knowledge, this is the first screen combining β-thalassemia and hemochromatosis mutations in a single test, so as to facilitate the early identification of patients who may be at increased potential risk for complications from iron overload and thereby to improve the prospective management of thalassemia patients.
Co-infection with Campylobacter and rotavirus in less than 5 year old children with acute gastroenteritis in Nepal during 2017-2018
Authors: Bhattarai Vishnu , Sharma Saroj , Rijal Komal Raj , Banjara Megha Raj 
Published: February 2020

Abstract
Background: Diarrhoea, although easily curable, is a global cause of death for a half million children every year. Rotavirus and Campylobacter are the most common etiological agents of diarrhoea in children less than 5 years of age. However, in Nepal, these causative agents are not routinely examined for the diagnosis and treatment. The main objective of this study was to determine Campylobacter co-infection associated with rotavirus diarrhoea in children less than 5 years of age. Methods: A cross-sectional study was conducted at Kanti Children's Hospital (KCH), Kathmandu, Nepal from November 2017 to April 2018. A total of 303 stool specimens from children affected with diarrhoea were processed to detect rotavirus using a rapid rotavirus antigen detection test kit, and Campylobacter by microscopy, culture and biochemical tests. Antibiotic susceptibility tests of Campylobacter isolates were performed according to European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines 2015. Results: Of 303 samples, 91 (30.0%) were positive for co-infection with rotavirus and Campylobacter . Rotavirus mono-infection was detected in 61 (20.1%), and Campylobacter mono-infection was detected in 81 (26.7%) samples. Patient’s age, month of infection, untreated water and frequent soil contact were the major risk factors for infections. Clinical features such as >9 loose motions per day, fever, vomiting, mild to moderate dehydration, diarrhea persisting 6-9 days and presence of mucus in stool were significant (p<0.05) clinical features, and were more severe in coinfection compared to mono-infections in multivariate analysis. Conclusion: The study shows a high rate of rotavirus and Campylobacter coinfection in children with diarrhoea. Diagnosis based management of diarrhoeal cases can guide the specific treatment. Keywords : Campylobacter , rotavirus, co-infection, diarrhoea, children
The Association between Parental Migration and Early Childhood Nutrition of Left-behind Children in Rural China
Authors: Shi Huifeng , Zhang Jingxu , Du Yufeng , Zhao Chunxia , Huang Xiaona , Wang Xiaoli 
Published: February 2020

Abstract

Background: More than one-third of children under 3 years old are left behind at home due to parental migration in rural China, and we know very little about early childhood nutrition of left-behind children (LBC) because of the dearth of research. This study examined the association between parental migration and early childhood nutrition of LBC in rural China.Methods: We used repeated cross-sectional data of rural children aged 6–35 months who participated in two surveys in six counties of northern and southern China in 2013 and 2016 respectively. The length, weight, and hemoglobin concentration were measured by trained health‑care workers blinded to parental migration status. Stunting, underweight, wasting, and anemia were identified with the standards recommended by WHO. Generalized linear regressions and multivariate logistic regressions were employed to explore the association between parental migration and these nutritional outcomes at each time point.Results: 2,336 and 2,210 children aged 6–35 months were enrolled in 2013 and 2016, respectively. The results show a reduction of the risks of stunting, underweight, and wasting from 2013 (16.4%, 8.5%, and 3.5%, respectively) to 2016 (12.1%, 4.0%, and 1.5%, respectively) but highlight a constantly and alarmingly high risk of anemia among these children (44.8% in 2013 and 43.8% in 2016). Children with migrant fathers performed as well as or better than those with non-migrants on these indicators. Children with migrant parents performed slightly worse in 2013, but equal or slightly superior in 2016 on these indicators compared with children with non-migrants and migrant fathers. Children aged 6–17 months with migrant parents had a significantly lower risk of anemia than those living with their mothers or with both parents (43.1% vs. 63.6% and 61.5 in 2013, and 42.5 vs. 60.1% and 66.2% in 2016), even after controlling for children’s sociodemographic characteristics.Conclusions: Parental migration may be not detrimental and even beneficial to early childhood nutrition of LBC in rural China. Continued nutritional support is needed for all rural children, especially interventions for preventing micronutrient deficiency. Programs for LBC are recommended to continue to focus on nutrition but pay more attention to other important health issues.
A multicenter randomized trial of personalized acupuncture, fixed acupuncture, letrozole, and placebo letrozole on live birth in infertile women with polycystic ovary syndrome
Authors: Huang Shiya , Hu Min , Ng Ernest Hung Yu , Stener-Victorin Elisabet , Zheng Yanhua , Wen Qidan , Wang Cong , Lai Maohua , Li Juan , Gao Xingcheng , Wang Xinhua , Hu Zhenxing , Xia Tian , Hu Rongkui , Liu Jianping , Wen Xiaohui , Li Shuna , Quan Kewei , Liang Xingyan , Shang Hongcai , Ma Hongxia , Qiao Jie 
Published: February 2020

Abstract
BACKGROUND Traditional Chinese medicine (TCM) usually involves syndrome differentiation and treatment. Acupuncture, one form of TCM, requires the selection of appropriate acupoints points and needling techniques, but many clinical trials on acupuncture have used fixed acupuncture protocols without accounting for individual differences among patients. We have designed a multicenter randomized controlled trial (RCT) to evaluate whether personalized or fixed acupuncture increases the likelihood of live births in infertile women with polycystic ovary syndrome (PCOS) compared with letrozole or placebo letrozole. We hypothesize that letrozole is more effective than personalized acupuncture, which in turn is more effective than fixed acupuncture, and that placebo letrozole is the least effective intervention. Moreover, we hypothesize that personalized acupuncture is more likely to reduce the miscarriage rate and the risk of pregnancy complications compared to letrozole. METHODS / DESIGN The study is designed as a randomized assessor-blinded controlled trial. A total of 1,100 infertile women with PCOS will be recruited from 28 hospitals and randomly allocated into four groups: A) personalized acupuncture, B) fixed acupuncture, C) letrozole, or D) placebo letrozole. They will receive treatment for 16 weeks, and the primary outcome is live birth. Secondary outcomes include ovulation rate, conception rate, pregnancy rate, pregnancy loss rate, changes in hormonal and metabolic parameters, and changes in quality of life scores. The adverse events will be recorded throughout the trial. All statistical analyses will be performed using the SPSS program V.21.0 (SPSS, Chicago, Illinois, USA), and a p-value <0.05 will be considered statistically significant. DISCUSSION This study will be the first multicenter RCT to compare personalized or fixed acupuncture with letrozole or placebo letrozole on live birth in infertile women with PCOS. The findings will inform whether personalized acupuncture therapy can be considered an alternative treatment to improve the live birth rate in infertile women with PCOS.
Computational MHC-I epitope predictor identifies 95% of experimentally mapped HIV-1 clade A and D epitopes in a Ugandan cohort.
Authors: Lule Daniel Bugembe , Ekii Andrew Obuku , Ndembi Nicaise , Serwanga Jennifer , Kaleebu Pontiano , Pala Pietro 
Published: February 2020

Abstract
Background: Identifying immunogens that induce HIV-1-specific immune responses is a lengthy process that can benefit from computational methods, which predict T-cell epitopes for various HLA types.
Methods: We tested the performance of the NetMHCpan4.0 computational neural network in re-identifying 93 T-cell epitopes that had been previously independently mapped using the whole proteome IFN-g ELISPOT assays in 6 HLA class I typed Ugandan individuals infected with HIV-1 subtypes A1 and D. To provide a benchmark we compared the predictions for NetMHCpan4.0 to MHCflurry1.2.0 and NetCTL1.2.
Results: NetMHCpan4.0 performed best correctly predicting 88 of the 93 experimentally mapped epitopes for a set length of 9-mer and matched HLA class I alleles. Receiver Operator Characteristic (ROC) analysis gave an area under the curve (AUC) of 0.928. Setting NetMHCpan4.0 to predict 11-14mer length did not improve the prediction (37-79 of 93 peptides) with an inverse correlation between the number of predictions and length set. Late time point peptides were significantly stronger binders than early peptides (Wilcoxon signed rank test: p =0.0000005). MHCflurry1.2.0 similarly predicted all but 2 of the peptides that NetMHCpan4.0 predicted and NetCTL1.2 predicted only 14 of the 93 experimental peptides.
Conclusion: NetMHCpan4.0 class I epitope predictions covered 95% of the epitope responses identified in six HIV-1 infected individuals, and would have reduced the number of experimental confirmatory tests by >80%. Algorithmic epitope prediction in conjunction with HLA allele frequency information can cost-effectively assist immunogen design through minimizing the experimental effort.
Keywords: HIV-1, epitope mapping, T-cell, artificial neural network, in-silico , NetMHCpan4.0., MHCflurry1.2.0 and NetCTL1.2.