bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors related to Pregnancy Outcome Among Lebanese Women During COVID-19 Confinement
Authors: Haddad Chadia , Malhab Sandrella Bou , Sacre Hala , Malaeb Diana , Azzi Joelle , Khachman Dalia , Lahoud Nathalie , Salameh Pascale 
Published: December 2020

Abstract
Background: During the coronavirus disease confinement, couples are likely to spend more free time together at home, which could have a positive impact on the amount and level of intimacy. However, home confinement and lockdowns have created challenges and vulnerabilities, causing relevant changes in sexual health and couple stability, particularly in women. The objective of this study was to evaluate the socio-economic and psychological factors related to current pregnancy status and unwanted pregnancy among a sample of Lebanese women during the COVID-19 lockdown.Methods: A cross-sectional online-based study was conducted between June 8 and August 1, 2020, among 369 Lebanese women. The questionnaire developed on Google Forms was distributed through social media and WhatsApp groups, using the snowball technique. The current pregnancy status and unwanted pregnancy were assessed using binary questions (Yes/No).Results: Our results showed that 11.1% of women were pregnant, of whom 22.0% reported unwanted pregnancies. Having children (ORa=0.183) and using contraceptives (ORa=0.231) were at lower odds of getting pregnant. Higher psychological violence would negatively affect pregnancy, but the association tended to significance (p=0.065). Also, regular visits to the physician for routine checkups (ORa=0.053) were significantly associated with lower odds of unwanted pregnancy. Higher psychological violence would affect unwanted pregnancy; however, the association tended to significance (p=0.056). Conclusion: Our main findings indicate that women of younger age, smoking less, and never working were at a higher probability of being pregnant. Furthermore, psychological violence tended to be an associated factor for current pregnancy status and unwanted pregnancy. More information and awareness are needed to encourage women to conceive and maintain their well-being during a pandemic.
Men’s Sheds as Community-based Health Promotion for Men Aged 50 Plus (MASH): Protocol for a Mixed-methods Systematic Review
Authors: Albrecht Birte , Foettinger Linda , Bammann Karin 
Published: December 2020

Abstract
Background Men are exposed to different health risks than women. For instance, older men have an increased risk of social isolation. At the same time, they are less likely to participate in health promotion interventions and there is a lack of men-specific interventions. Men’s sheds are a concept of community-based health promotion for older men where they can engage in joint activities. Prior research revealed various health-related effects of men’s sheds, such as reduced social isolation and improved psychological well-being. Yet, only two reviews conducted in 2013 are available which both found an insufficient evidence base. Since the wider implementation of men’s sheds is a recent phenomenon, and most of the literature on men’s sheds has been published after 2013, a mixed-methods systematic review will be conducted to strengthen the current evidence base of men’s sheds by analysing their effectiveness regarding self-rated health, subjective well-being, and social isolation. Moreover, information on how to successfully implement men’s sheds will be gathered. Methods This mixed-methods systematic review will follow the guidelines of The Joanna Briggs Institute (JBI). The databases Medline (via PubMed), Scopus, Web of Science, OpenGrey, and the websites of men’s sheds associations will be searched for publications. Additionally, a hand-search in the reference lists of the included publications will be conducted. Qualitative and quantitative studies published in English, German, or French will be considered for inclusion. The quality of the selected studies will be assessed using the JBI critical appraisal checklists. Following the convergent segregated approach, the data synthesis will be undertaken independently, and subsequently combined in a mixed-methods data synthesis.Discussion The results of this systematic review will lead to a comprehensive understanding of the current evidence base regarding the effectiveness of men’s sheds. Furthermore, they will provide useful implications for the implementation of men’s sheds. Systematic review registration The systematic review is registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number forthcoming).
Procedure and Patient-Related Risk Factors for Post-ERCP Pancreatitis Associated with Prophylactic Pancreatic Stent and Rectal Indomethacin
Authors: Ghalehnoei Hossein , Hormati Ahmad , Alizadeh Amir Houshang Mohammad , Ahmadpour Sajjad , Abedi Hassan 
Published: December 2020

Abstract
Background: Pancreatitis is one of the most crucial complications following endoscopic retrograde cholangiopancreatography (ERCP). The purpose of the current study was to investigate a potential procedure and patient-related risk factors for post-ERCP pancreatitis (PEP) in two groups: prophylactic pancreatic stent and rectal indomethacin.Methods: Two different prophylactic modalities were planned and complications were assessed based on defined inclusion criteria. In this study, the patients were evaluated for the procedure and patient-related risk factors in post-ERCP pancreatitis in the recipient groups of the prophylactic pancreatic stent or rectal indomethacin.Results: Pancreatitis was confirmed in 27 of all 175 selected patients after ERCP. By univariate analysis, two variables were significant with the development of PEP. Regarding the patient-related risk factors, unique subjects with common bile duct(CBD) dilated 10mm were more exposed to an increased chance of PEP (p=0. 015); meanwhile, other factors didn’t correlate with the increased possibility of PEP in both groups. The only procedure-related risk factor for PEP was deep cannulation of the pancreatic duct in both groups during the procedure with an incremental significant incidence of pancreatitis (p=0.005). Prophylactic pancreatic stent and rectal indomethacin showed no effects on reducing post ERCP pancreatitis. Additionally, there was no significant difference between these two strategies in the rate of PEP.Conclusion: Prophylactic pancreatic duct stents and administration of rectal indomethacin cannot have particular methods for reducing the occurrence of PEP. The increase in time of deep cannulation and the presence of CBD dilation <10mm could be considered as important risk factors.
Kirschner Wire as a Reference Marker for the Positioning of a Syndesmotic Screw: A Radiological Study
Authors: zhang congming , Wang Qian , Duan Ning , Ma Teng , Xuan Hangzhong , Zhang Kun , Li Zhong 
Published: December 2020

Abstract
Background: Without a reliable and static reference, the rate of eccentrically positioned distal syndesmotic screw trajectories is very high. Meanwhile, a malpositioned screw may result in poor outcomes and early osteoarthritis. As such, this article describes an additional method to improve surgeons’ ability to ideally place a screw trajectory. The purposes of our study were (1) to determine if an ideal space at 2.5 cm proximal to the plafond existed between the tibia and fibula for the placement of a Kirschner (K) wire and (2) to detect if it could act as a reliable and static fibular incisura plane reference.Methods: Computed tomography scans of 42 uninjured adult ankles with foot fractures were analysed to measure the tibiofibular vertical distance (TFVD) at 2.5 cm proximal to the tibial plafond on cross-sectional images. The TFVD was defined as the distance between two lines: Line 1 was tangent to the fibular incisura, and Line 2 was parallel to Line 1 along the medial border of the fibula. Patients were divided into 4 groups according to our TFVD data: 0–1, 1–2, 2–3, and 3–4 mm, and the number of patients in each group was counted.Results: The TFVD measured 2.23±1.01 mm (mean ± standard deviation) at 2.5 cm proximal to the plafond. According to our grouping, TFVD occurred at 25% of the distance from 2 to 3 mm in 47.6% of patients. Conclusions: Placing a 1.6-mm K-wire in the syndesmosis at 2.5 cm proximal to the tibial plafond is easy because of emerging TFVDs. The K-wire’s path is restricted to the anterior and posterior borders of the fibular incisura pass because of the limitation of the medial border of the fibula and syndesmosis tendon. Therefore, K-wire could be used as a reliable and static intraoperative reference of the fibular incisura plane through which surgeons can accurately place a screw trajectory.
Age Impacts the Local Immune Response to Tuberculin Skin Challenge in Mycobacterium Bovis BCG-vaccinated Baboons
Authors: Scordo Julia Marianna , Piergallini Tucker J. , Reuter Nicole D , Headley Colwyn A. , Hodara Vida L. , Gonzalez Olga , Giavedoni Luis D. , Papin James F. , Turner Joanne 
Published: December 2020

Abstract
Background - Individuals over the age of 65 are highly susceptible to infectious diseases, which account for one-third of deaths in this age group. Vaccines are a primary tool to combat infection, yet they are less effective in the elderly population. While many groups have aimed to address this problem by studying vaccine-induced peripheral blood responses in the elderly, work from our lab and others demonstrate that immune responses to vaccination and infectious challenge may differ between tissue sites and the periphery. To improve health outcomes in our aged population, we must study vaccine responses in the tissue. Here we established an in vivo delayed-type hypersensitivity model of Mycobacterium bovis BCG vaccination and tuberculin skin test (TST) in adult and aged baboons. Vaccination generates BCG-specific immune cells that are recruited to the skin upon tuberculin challenge. We tested short-term recall responses (8 weeks post-vaccination) and long term recall responses (25 weeks post-vaccination) by performing skin punch biopsies around the site of tuberculin injection. In parallel, we determined BCG-induced responses in the peripheral blood of vaccinated animals. Results - In short term recall responses, we found increased oxidation and decreased production of immune proteins in aged baboon skin at the site of TST challenge, in comparison to adult skin. Differences between adult and aged animals normalized in the long term response to tuberculin. Phenotypic analysis of aged peripheral blood cells found several age-related changes in immune cell populations, independent of BCG vaccination, and no impairment in functional responses. Moreover, aged peripheral blood mononuclear cells had increased migration in vitro, suggesting that age-related changes in the tissue in vivo impairs aged immune recall responses to antigenic challenge. Conclusions - These findings highlight the impact of age-associated changes in the local tissue environment in memory recall responses, which may be more broadly applied to the study of other tissues. Moreover, these findings should be considered in future studies aimed at understanding and improving aging immune responses to vaccination and tissue challenge.
A case report of triple primary malignant tumors including breast,cervical and thyroid cancers with CHEK2 and PIK3CA mutation
Authors: Xiao Ruoxi , Wang Shasha , Sun Libin , Zhang Yongchun , Li Hui , Wang Gongjun , Liu Zhao , Qi Weiwei , Qiu Wensheng 
Published: December 2020

Abstract
IntroductionTo the best of our knowledge the combination of multiple synchronous primary malignant tumors which involves breast carcinoma, thyroid carcinoma and cervical carcinoma has not been previously reported.Case reportHerein, we report a 47-year-old female who was diagnosed with multiple synchronous primary malignancies: cervical squamous-cell carcinoma, invasive ductal carcinoma of left breast, papillary carcinoma of the left thyroid gland and had a gene mutation of both CHEK2 and PIK3CA. We adopted a comprehensive treatment approach .ConclusionWhen a cancer patient presents with the clinical manifestation of another tumor, the possibility of synchronous occurrence of multiple primary malignant tumors, as well as tumor metastasis should be considered. In addition, the follow-up time of patients with malignant tumors should be extended, because timely detection and treatment of more primary malignancies may extend the survival time of patients and improve their quality of life.
Increasing Hemagglutination Inhibition Antibodies against Two Lineages of Type B Influenza Virus in 2017-2018 Winter Season in Beijing, China
Authors: Yao Yao , CHEN Lingling , ZHU Dong , LI Runqing , ZHAO Zhipeng , SONG Wenqi , Zhao Xiuying , Qin Kun 
Published: December 2020

Abstract
Influenza virus circulates every year with lower activity than that of influenza A virus in China. During 2017 to 2018 winter season, a sharp surge of influenza activity dominated by type B/Yamagata lineage virus caused unprecedented medical burden in Beijing. The research aimed to understand the underlying mechanism for this circulation and be prepared for epidemics in the future. Sera samples collected from the patients in 2016-2017 and 2017-2018 flu seasons were tested for profiling hemagglutinin inhibition (HI) antibodies against both prevailing Victoria and Yamagata lineages of type B influenza viruses. It showed that the seroprevalence against both lineages of the virus in 2017-2018 winter was higher than that in 2016-2017, while no difference of the seroprevalence was observed between the two viruses. Meanwhile, significant elevated geometric mean titer (GMT) against both lineages of influenza B viruses was found in the specimens collected during 2017-2018 flu season than that from 2016-2017, suggesting the viruses might undergo antigenic changes. These results also suggested that lower GMT against both type B variants in 2016-2017 might serve as an immunological niche for the dominating of B/Yamagata virus in China during 2017-2018 winter season. Our findings have implication that there was a significantly elevation of HI antibodies to influenza viruses B in 2017-2018, compared in 2016-2017. On the other hand, the low level of HI antibodies to both B/Y and B/V in 2016-2017 could contribute to the severe B/Y epidemic in 2017-2018 to some extent.
Monitoring Treatment Response In Patients Undergoing Concurrent Chemoradiotherapy for Locally Advanced Uterine Cervical Carcinoma Using Intravoxel Incoherent Motion Imaging: A Systematic Review And Meta-Analysis
Authors: Qin Lan-hui , He Feng-yi , Wen Shuang , Xiang Yan-han , Wei Yan-sha , Liao Jin-yuan , Liu Jiaming 
Published: December 2020

Abstract
Background: To the best of our knowledge, there are no systematic reviews or meta-analyses on the use of IVIM to assess treatment response of cervical cancer patients undergoing CCRT. Therefore, this study aimed to determine the role and optimal parameters of intravoxel incoherent motion imaging (IVIM) for evaluating treatment response in patients undergoing concurrent chemoradiotherapy (CCRT) for uterine cervical cancer.Methods: We searched the PubMed, PMC, EMBASE, Cochrane Library, and Ovid databases. Two reviewers independently performed data extraction, checked patient inclusion criteria, conducted the imaging protocols and follow-up for treatment response, recorded IVIM parameters, and performed quality assessment.Results: Six studies with 237 patients were included in our meta-analysis. The mean patient age ranged between 47 and 69 years. The International Federation of Gynecology and Obstetrics (FIGO) staging varied from Ib1 to IVb. The pooled mean values of apparent diffusion coefficient (ADC), tissue diffusion (D), and perfusion fraction (f) were 0.51, 0.18, and 6.24, respectively, in the complete response (CR) group, while the values were 0.38, 0.16, and 5.84, respectively, in the non-complete response (non-CR) group. In the subgroup meta-analysis, the ADC and D values in the CR group were higher compared to the non-CR group. Similarly, the incremental increase in f values in the CR group was higher compared to the non-CR groups (3.26, 5.84). All studies had a higher risk of bias in quality assessment due to study confounding and attrition.Conclusions: IVIM could be used to monitor the pre- and post-treatment response of cervical cancer patients undergoing CCRT. Early response assessment could begin 1 week after CCRT. However, we were unable to determine the optimal IVIM parameter from our analysis.
Normal Faulting Movement During the 2020 Mw 6.4 Yutian Earthquake: A Shallow Rupture in NW Tibet Revealed by Geodetic Measurements
Authors: Yu Jiansheng , Wang Dongzhen , Zhao Bin , Qi Li 
Published: December 2020

Abstract
The ENE striking Longmu Co fault and the North Altyn Tagh left-lateral slip fault have led to the complex regional structure in the northwestern Tibetan Plateau, resulting in a series of normal faulting and strike slip faulting earthquakes. Using both the ascending and descending Sentinel-1A/B radar images, we depict the coseismic deformation caused by the 2020 Yutian Mw 6.4 earthquake with a peak subsidence of ~20 cm. We determine the seismogenic fault geometry by applying the Bayesian approach with a Markov Chain Monte Carlo sampling method, which enables us to find the posterior probability density functions of the source model parameters. The estimation results reveal that the earthquake have dominantly by normal slip with moderate strike slip component. Based on the optimal fault geometry model, we extend the fault plane and invert for the finite fault model dislocation, which indicate that the slip is mainly concentrated at a shallow focal depth of 3–10 km with a maximum slip of ~1.0 m. Our preferred geodetic coseismic model exhibits no surface rupture, which may likely due to the shallow slip deficit in the uppermost crust. We calculate the combined loading effect of the Coulomb failure stress changes induced by the coseismic dislocations and postseismic viscoelastic relaxation of the 2008 Mw 7.1 and 2014 Mw 6.9 Yutian events. Our study demonstrates that the two preceding major Yutian shocks were insufficient to trigger the 2020 Yutian earthquake, which we consider perhaps reflects the natural release of elastic strain accumulated mainly through localized tectonic movement. We attribute the 2020 Yutian event to the release of extensional stress in a stepover zone controlled by the Longmu Co and the North Altyn Tagh sinistral strike slip fault systems. The seismic risk in the southwest end of the North Altyn Tagh fault has been elevated by the Yutian earthquake sequences, which require future attention.
The use of inappropriate anal douching tool associates with increased HIV infection among men who have sex with men: a cross-sectional study in Shenyang, China
Authors: Chu ZhenXing , Shen Guangquan , Hu Qinghai , Wang Hongyi , Zhang Jing , Dong Willa , Jiang Yongjun , Geng Wenqing , Shang Hong , Xu Junjie 
Published: December 2020

Abstract
Background: Rectal douching (RD) is widely practiced by men who have sex with men (MSM), and is associated with increased risk of HIV infection. However, the mechanism of how RD increases the risk of HIV infection is not well understood, and there is limited data on RD behavior in MSM practicing anal sex in China. We examine the purpose of RD, its timing in relation to anal sex, the types of RD products used, and risky sexual behaviors among MSM reporting anal sex.Methods: Between August 2017 and December 2018, a cross-sectional study was conducted among adult MSM in Shenyang, China. Data were collected on demographics, sexual behaviors, and RD for the most recent sexual intercourse by means of interviewer-administered face-to-face questionnaires. Blood samples were collected to test for antibodies to HIV and syphilis. Multivariable logistic regression models were used to assess the risk factors associated with HIV infection.Results: A total of 515 eligible MSM participated in this survey (median age: 31 years). During the most recent anal intercourse, 28.3% (146/515) had condomless receptive anal intercourse (CRAI), 21.4% (110/515) practiced serosorting, and more than half (61.6%, 317/515) reported RD before or after anal sex. Of those practicing RD, 96.8% (307/317) conducted RD before sex, while 62.5% (198/317) conducted RD after sex. The douching devices used were primarily shower hoses (85.3%, 262/307), and relatively few MSM used commercial RD products (8.1%, 25/307) before sex. The prevalence of HIV-1 and syphilis was 11.7% and 13.2%, respectively. HIV infection was positively associated with RD (adjusted odds ratio (AOR), 2.8; 95% confidence interval (CI), 1.4-5.5), practicing RD before sex (AOR, 2.3; 95% CI, 1.2–4.3), practicing RD after sex (AOR, 1.8; 95% CI, 1.0–3.1), using a shower hose for RD (AOR, 3.5; 95% CI, 1.1–13.0), CRAI (AOR, 2.9; 95% CI, 1.6–5.5), and an interaction effect of RD and CRAI (AOR = 4.2; 95 % CI, 2.2- 8.1) in the most recent anal intercourse.Conclusions: RD is popular among Chinese MSM. Improper noncommercial RD tools use (such as shower hose), the interaction effect between RD and CRAI associated with HIV infection. Public health workers and the MSM community should publicize scientific knowledge and prevention approaches relating to RD and HIV transmission to MSM. We recommend that further studies should be conducted to understand the detailed mechanism between RD and increased HIV prevalence.