bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-alcoholic fatty liver disease and left ventricular diastolic dysfunction in patients with metabolic syndrome
Authors: Jadhav S. N. , Radchenko V. G. 
Published: November 2020

The purpose of the study was to determine the frequency and nature of manifestations of left ventricular diastolic dysfunction in patients with non-alcoholic fatty liver disease with the background of metabolic syndrome (MS).Characteristics of patients and research methods: To solve this problem, 227 patients with MS (130 men and 97 women) were examined. The study was conducted in two phases. At the ﬁrst stage, all patients with MS are divided into two groups: patients with NAFLD — 205 people and 22 — without liver damage. At the next stage, a group of NAFLD patients with left ventricular DD (n=136) (66.34%) (the main group) and patients with no DD (n=69) (33.66%) (the comparison group) were identiﬁed.Results of the study: the results of diagnostics, clinical and laboratory manifestations of left ventricular diastolic dysfunction in 136 patients with NAFLD on the background of metabolic syndrome are Presented. Signiﬁcant factors of development and progression of diastolic dysfunction were identiﬁed, which include increased body weight and adipose tissue, insulin resistance, dyslipidemia, hyperuricemia, activity and stage of liver damage. According to the data of structural and functional changes in the myocardium, the role of diastolic dysfunction in the development of chronic heart failure in patients with NAFLD with manifestations of metabolic syndrome has been established.Conclusion: it was Found that the development of left ventricular diastolic dysfunction in patients with NAFLD is due to the morphofunctional state of the liver.
Parallels between non-alcoholic fatty liver disease and non-alcoholic fatty pancreatic disease: looking for points of contact or regard through the lens of metabolic syndrome
Authors: Gubergrits N. B. , Byelyayeva N. V. , Mozhyna T. L. 
Published: November 2020

The aim. The aim of our study was to analyze the available data from literature sources concerning the issues of etiology, pathogenesis, clinic, diagnosis and features of treatment of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic fatty pancreatic disease (NAFPD).Materials and methods. We conducted a retrospective analysis of foreign literature sources that contain up-to-date information about the state of the problem of NAFLD and NAFPD.Results. NAFLD and NAFPD develop against the background of metabolic syndrome (MS), systemic insulin resistance, oxidative stress, changes in lipid metabolism. The natural course of NAFPD is associated with high risk of MS progression, occurrence of NAFLD, arterial hypertension, type 2 diabetes mellitus, exocrine pancreatic insuﬃciency, acute and chronic pancreatitis, pancreas cancer. Correction of the components of MS can reduce the severity of NAFLD and NAFPD; enzyme replacement therapy can improve the function of β-cells in pancreas steatosis.Conclusion. The alternatives of the pharmacological treatment of NAFLD and NAFPD continue to be actively explored. We emphasize the need of including medications containing pancreatic enzymes in the treatment of NAFLD.
Dietary Deficiencies Exacerbate Disparity in COVID-19 and Nutrition Recommendations for Vulnerable Populations
Authors: Polamarasetti Pooja 
Published: November 2020

Marginalized populations face health disparity due to multiple different avenues during the 2020 COVID-19 pandemic: 1.Direct COVID-19 infection and hospitalization, 2.Poor overall health and nutrition leading tocomorbidity and worsened outcomes, and 3.Difficult social conditions such as workplacehygiene, living conditions, and transportation.These three identified issues are cyclical in nature and both cause and affect the others. This article studies each of these factors using a literature review, especially in the experience of certain demographics, including elderly, low-income, racial minorities, urban, and institutionalized persons. We then delve into recommendations that can be considered for each of these issues and specific populations. Recommendations can be given to policymakers, public health officials, and epidemiologists as well as basic science researchers and food producers to attack the disparity from both sides. These findings and ideas may be used to improve both nutrition accessibility as well as COVID-19 disparity for these most vulnerable populations.Keywords: COVID-19, SARS-CoV-2, coronavirus, deficiency, elderly, urban, race, socioeconomic status, disparity, nutrition, diet
A behavior analysis of brazilian farmers based on sunk cost effects and prospect theory
Authors: Leal Denizar , Queiroz Daniely Tranhago de , Rodrigues Roberta Araújo 
Published: November 2020

Purpose: identify whether the sunk cost effect is one of the reasons that make banana producers in Espírito Santo, a Brazilian state, make decisions that involve returning home with unsold production.
Methodology/Approach: It is an exploratory and descriptive study of multiple cases. The object of study was 17 banana producers from Espírito Santo, who sell their products in Supply Centers of Espírito Santo (CEASA). Data collection was carried out through interviews
Findings: The results found demonstrate that producers are reluctant to sell below cost price, noting that there is an influence of sunk costs in their decisions. Another finding is that the fear of loss, which is one of the pillars of the Prospect Theory, also influences the decisions of producers, in the sense of trying to avoid future losses
Research Limitation: the methodology used does not allow inferences about the behavior of all producers.
Originality/Value of paper: This study confirms that knowledge of costs in the decision-making process is fundamental in any business, since if producers were not influenced by the sunk cost effect, they would probably have better results in this activity.
Cationic amphiphiles based on malonic acid amides as transfection mediators
Authors: Romanova N. A. , Budanova U. A. , Sebyakin Yu. L. 
Published: November 2020

Objectives. The aim of this work is to synthesize cationic amphiphiles based on malonic acid amides. The target compounds should contain saturated and unsaturated alkyl chains in the hydrophobic portion, and one or two positive charges in the polar head as created by ethylenediamine and amino acid L-ornithine. For such cationic amphiphiles, we determined physicochemical properties and transfection efficiency of liposomes based on them.Methods. The initial compound in the synthesis is diethylmalonate. We used C-alkylation to add the first hydrophobic chain (with octylbromide, dodecylbromide, or octadecylbromide). N-oleylamine was used as the second hydrophobic chain, which was attached at the carboxyl group of the malonic acid via amide bond formation. The polar head was represented by ethylenediamine, which was then attached at the second carboxyl group of the malonic acid. Further, L-ornithine was attached to ethylenediamine to produce cationic lipids with two positive charges in the head group. The structures of the compounds were characterized by infrared spectroscopy, nuclear magnetic resonance spectroscopy, and elemental analysis. Particle size distribution was evaluated by photon correlation spectroscopy. The luciferase test was used to determine transfection efficiency using HeLa cells.Results. We have developed a synthesis scheme to produce new cationic amphiphiles with an asymmetric hydrophobic part. The obtained liposomal particles are approximately 120 nm in size and have a relatively high zeta potential of 29–30 mV.Conclusions. The size of these liposomes allows them to penetrate into cells, which makes it possible to use these compositions for transfection. The high zeta potential shows that the particles are stable. Our results demonstrate that the transfection efficiency of our liposomes (mixed with cholesterol) is comparable to a commercial formulation. Cationic amphiphiles based on malonic acid amides have great potential for liposome development for transfection.
Influence of iron ore concentrate (magnetite) on the kinetics of butadiene–styrene rubber-based blend curing in the presence of different accelerators
Authors: Khachaturov A. A. , Potapov E. E. , Reznichenko S. V. , Kovaleva A. N. 
Published: November 2020

Objectives. To investigate the possibility of using a cheaper ingredient, such as magnetite, in the synthesis of rubber compounds based on butadiene–styrene rubber by examining its effect on the process of sulfuric vulcanization of butadiene–styrene rubber in the presence of various accelerators.Methods. The influence of magnetite on the vulcanization kinetics was studied using an Alpha Technologies PRPA 2000 rotorless rheometer. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were performed using a Mettler Toledo TGA/DSC 2 device to evaluate the effect of magnetite on the butadiene–styrene rubber-based vulcanizates’ oxidation.Results. Magnetite was found to affect the kinetics of SBR-1500 butadiene–styrene rubber sulfuric vulcanization in the presence of thiazole-type accelerators (2-MBT, 2-MBS); in contrast, magnetite was inactive in the case of diphenylguanidine, sulfenamide T, and tetramethylthiuram disulfide. The obtained TGA/DSC data showed that magnetite has no significant effect on the butadiene–styrene rubber-based vulcanizates’ oxidation and thermal destruction.Conclusions. The obtained data confirmed magnetite’s capability to act as a butadiene–styrene rubber sulfuric vulcanization activator in the presence of various accelerators. The most significant effect was observed in the presence of thiazole-type accelerators.
Determining the phase stability of luminescent materials based on the solid solutions of oxyorthosilicates (Lu<sub>1−x</sub>Ln<sub>x</sub>)[(SiO<sub>4</sub>)<sub>0.5</sub>O<sub>0.5</sub>], where Ln = La−Yb
Authors: Get’man E. I. , Oleksii Yu. A. , Radio S. V. , Ardanova L. I. 
Published: November 2020

Objectives. This study aimed to predict the limits of substitution and stability of luminescent materials based on low-temperature modifications of solid solutions (spatial group P21/c) with lutetium oxyorthosilicates (Lu1−xLnx)[(SiO4)0.5O0.5], where Ln represents the rare-earth elements (REEs) of the La–Yb series.Methods. The V.S. Urusov’s crystal energy theory of isomorphous substitutions and a crystallochemical approach in the regular solid solution approximation were used to calculate the energies of the mixing (interaction parameters) of the solid solutions.Results. Using the V.S. Urusov’s theory, we calculated the energies of mixing (interaction parameters) in the systems under study. The dependences of the decomposition temperatures of solid solutions on the REE number and composition (x) were obtained and used to create a diagram of the thermodynamic stability of the solid solutions, allowing us to predict the substitution limits depending on the temperature or determine the decomposition temperature using the given substitution limits.Conclusions. The results of the study can be useful when choosing the ratio of components in matrices (host materials) and the amount of the activator (dopant) in the new luminescent, laser, and other materials based on low-temperature modifications of solid solutions of “mixed” REE oxyorthosilicates (Lu1−xLnx)[(SiO4)0.5O0.5].
Contact crystallization of substances from solutions using evaporating refrigerants
Authors: Nоsоv G. A. , Uvаrоv M. E. 
Published: November 2020

Objectives. The aim of this study was to analyze the possibility of using contact crystallization with evaporating refrigerants for the isolation of substances from their aqueous solutions using salts [KNO3, NaI, and (NH2)2CO] as extraction examples and sucrose. Isobutane was used as a refrigerant.Methods. The analysis of the influence of the main technological parameters (i.e., solution’s cooling temperature, initial concentration, and compressed refrigerant vapor pressure) on the separation process and identification of its regularities was performed using mathematical dependencies previously developed by N.I. Gelperin and G.A. Nosov for each stage of the contact crystallization process. The authors studied the influence of these parameters on the yield of crystalline and liquid phases, refrigerant consumption, and compressor power.Results. The study showed that the use of evaporating refrigerants can significantly intensify the process of separating the mixture and spent refrigerant from the resulting crystalline suspension. This occurs owing to the evaporation of the liquid refrigerant that is in contact with the solution, which is accompanied by intense cooling. This process can be carried out at the temperature difference between the refrigerant and crystallizing mixture in the range of 0.5–1.0°C.Conclusions. Contact crystallization with evaporating refrigerants can be successfully applied to separate various substances from aqueous solutions. An important advantage of this process is the relatively low refrigerant consumption because heat removal from the solution is carried out as a result of changes in the aggregate state of the refrigerant. The use of contact crystallization can also considerably simplify the equipment.
Agen Biologik Psoriasis Terkini
Authors: Nopriyati  , Reza Mayasari  
Published: November 2020

ABSTRAK
Psoriasis adalah penyakit inflamasi kulit kronik dengan dasar genetik, ditandai gangguan pertumbuhan dan diferensiasi epidermis, biokimiamultipel, imunologis, serta kelainan vaskular. Terapi sistemik standar berupa metotreksat, siklosporin, dan asitretinsangatefektif, tetapimenimbulkantoksisitas yang signifikan. Surveinasional di Amerika menunjukkan tingkat ketidakpuasan tinggi terhadap terapi sistemik standar tersebut. Selama satu decade terakhir,dikembangkan terapibiologik sebagai terapi pilihan psoriasis. Belum ada kesepakatan ahli mengkategorikan agenterapibiologik psoriasis dalam terapi terdahulu dan terkini. Kelompok agenterapibiologik terdahulu mencakup molekul yang menargetkan aktivasi dan migrasi sel T, yaitu alefacept dan efalizumab. Setelah itu, dikembangkan agenbiologikgenerasi pertama dengan target TNFα, yaitu etanercept, infliximab, dan adalimumab. Pada tahun 2009 dikembangkanagen biologik generasi keduadengan target pada jalur IL- 23 / Th17. Agenterapibiologikbaru, yaitu ustekinumab dengan target jalur IL-12/IL-23p40, secukinumabjalur IL-17A, ixekizumabjalur IL-17A, dan brodalumabjalur IL-17RA dikembangkan pada tahunberikutnya.
Developing Reading Material based Think Pair Share Model to Enhance Students' Reading Skill on Fourth Semester English Students Prof. DR. Hazairin, SH University.
Authors: Utami Elva Utami , Marita Yosi Marita 
Published: November 2020

This study aimed to produce Reading Teaching Materials which valid and effective. It can use to the students especially for Reading subjects. Research and development design was used for this study. The research was conducted at Fourth Semester English Students Prof. DR. Hazairin, SH University. Data collecting techniques used were tests, interviews, and questionnaires. The Data were analyzed using descriptive analysis of quantitative and qualitative. The results showed that the materials developed are valid, and effective. The validity showed from the assessment of lesson plan (RPS), student worksheet (LKS), teaching materials, and tests of learning outcomes. While the effectiveness of reading teaching materials based on Think Pair Share model that have been developed by learning activity indicated enthusiastic students in the learning process by using Think Pair Share model achievements approval â‰¥ 75%. In addition to the learning outcomes of students have reached 92,5%. While the response of students to the learning process that had been conducted shows that the high positive response, the above achievements calculating response was 80%. Based on the results of data analysis, it can be concluded that the Reading teaching materials based Think Pair Share Model can be used and implemented on students, especially in the subject of Reading.
Keywords : reading material, think pair share, reading skills.
Formulasi Gel Ekstrak Bunga Bougainvillea glabra dan Uji Potensi Tabir Surya dengan Metode Spektrofotometri UV Vis
Authors: Aji Nur 
Published: November 2020

Telah dilakukan penelitian potensi ekstrak bunga bugenvil sebagai tabir surya dalam sediaan gel. Penelitian ini dilakukan untuk menguji kandungan kimia bungan bugenvil, menguji potensi tabir surya ekstrak bunga bugenvil dan formulasi dalam sediaan gel menggunakan metode Spektrofotometri UV-Vis. Hasil penelitian ini menunjukan, ekstrak bunga bugenvil memiliki kandungan kimia yang merupakan golongan saponin, steroid, alkaloid, dan polifenol. Ekstrak bunga bugenvil memiliki nilai SPF tertinggi pada konsenterasi 1,5 % yaitu sebesar 16,96 dan dikategorikan memiliki daya proteksi sedang. Sediaan gel memiliki pH berada dalam kisaran 7 sampai 7,4, merupakan pH yang dapat diterima kulit. Selain itu gel memiliki viskositas pada kisaran 1.011.657 cP sampai 1.180.781 cP. Formula dengan konsentrasi ekstrak 1% merupakan formula yang memiliki viskositas tertinggi. Penambahan dan pengurangan konsentrasi ekstrak dari 1% pada sediaan gel menyebabkan penurunan viskositas. Sediaan memiliki daya sebar berkisar antara 17,60 sampai 29,23 cm2 pada kisaran tersebut gel mudah diaplikasikan pada kulit. Sediaan gel memiliki nilai SPF tertinggi pada formula keempat dengan konsenterasi ekstrak sebesar 1,5% menghasilkan nilai SPF sebesar 28,77 dengan kategori proteksi sedang.
PEMANFAATAN ROLL OVER TEST DAN MEAN ARTERY PRESSURE DALAM DETEKSI DINI RISIKO PREEKLAMPSIA
Authors: Esyuananik Esyuananik , Wayanti Sri , Wulan Dwi Wahyu , Irawati Deasy 
Published: November 2020

Preeklampsia merupakan salah satu komplikasi kehamilan dan menjadi penyebab kematian ibu maupun janin. Preeklampsia di Indonesia merupakan penyebab kematian ibu kedua (12,9%) setelah perdarahan (45,2%) Di Jawa Timur, penyebab dari kematian ibu tahun 2011: perdarahan 35,38%, pre eklamsia/eklampsia 29,23% dan infeksi 3,84%. Di Puskesmas Socah, pada tahun 2016 terdapat 5 orang dengan Preeklampsi berat. Perlu dilakukan pendampingan dan pemeriksaan ante natal care secara teratur dan komprehensif bagi ibu primigravida agar dapat mengetahui sejak dini komplikasi kehamilan dan tindakan konseling pra hamil, hamil dan pasca hamil. Ada beberapa metode deteksi dini untuk mengetahui faktor resiko pre eklamsi pada ibu hamil. Salah satu diantaranya adalah dengan menggunakan pemeriksaan Roll over-test dan Mean arterial Pressure. Pemeriksaan ini sangat mudah dan murah, sehingga bisa dilakukan oleh tenaga kesehatan baik di tingkat dasar maupun di pelayanan tingkat lanjut. Pelayanan kesehatan ibu hamil TM II di Puskesmas Socah berjalan dengan baik. Dari 54 bumil TM II yang memeriksakan kehamilannya, terdapat 15 orang (27,75) yang terdeteksi berisiko PE. Selaian untuk mendeteksi secara dini PE, kegiatan pengabdian masyarakat juga bertujuan menggerakkan peran serta keluarga dan masyarakat, untuk mendeteksi agar PE dapat segera diketahui secara dini sehingga tidak berlanjut ke kejadian PEB
Acondicionamiento y evaluación de tratamientos de desinfección para la micropropagación de Sagittaria macrophylla zucc. procedente de las Ciénegas del Rio Lerma
Authors: Martínez De la Cruz Julio C. , Aguilar Morales María A. , De la Cruz Olvera Armandina , Cruz Monterrosa Rosy G. , Diaz Ramírez Mayra , Jiménez Guzmán Judith , García Garibay Mariano , Miranda de la Lama Genaro C. , León Espinoza Erika B. , Fabela Morón Miriam F. , Rayas Amor Adolfo A. 
Published: November 2020

Objetivo: Evaluar el método de acondicionamiento y desinfección de Sagittaria macrophylla zucc. (Alismataceae) de la Cienega de Lerma, para su propagación y conservación.
Diseño/ metodología/ aproximación: En el invernadero se estableció un diseño completamente al azar con tres repeticiones para evaluar dos tipos de sustrato para S. macrophylla, se evaluó el número y longitud de brotes sanos. El primer sustrato consistió en una mezcla de tierra negra y agrolita con una proporción de 2:1, respectivamente (S1); el segundo sustrato se consideró el control ya que consistió en sedimentos de la Ciénega del Rio Lerma (S2). Para evaluar un método de desinfección adecuado se estableció un diseño de bloques completos al azar en donde los tratamientos consistieron en: lavados+ etanol al 70%+ cloro comercial (T1) y lavados+ microdin-jabón líquido+ etanol al 70%+ cloro comercial (T2). Las condiciones de fotoperiodo (luz y oscuridad) representaron los bloques del diseño experimental.
Resultados: En el experimento de tipo de sustrato se obtuvieron diferencias estadísticas significativas (P<0.05) entre los tratamientos en donde S1 mostro 2.4±0.24 brotes en promedio con una longitud de 2.5 cm en 30 días y con tendencia a incrementar. En el experimento de desinfección se observaron diferencias estadísticas significativas (P<0.05), sin embargo el fotoperiodo no presento diferencias significativas (P>0.05). El T2 presento el menor porcentaje de contaminación 31.25%.
Limitaciones del estudio/implicaciones: los resultados presentados son avances de un experimento a largo plazo.
Hallazgos/conclusiones: El acondicionamiento de plantas madre de S. macrophylla es favorable en condiciones de invernadero en un sustrato compuesto por tierra negra y agrolita 2:1 permitiendo brotes nuevos y sanos. El mejor método de desinfección consistió en un enjuague a chorro de agua con jabón en polvo, 30 minutos con 100 ml de agua destilada más una gota de microdin comercial y dos de jabón líquido, dos minutos en agitación constante en etanol al 70% y 20 minutos en cloro comercial (6%) al 30% v/v, utilizando como explantes las yemas axilares de los tubérculos sin importar el fotoperiodo en el cuarto de incubación.
Assessment of land-use change in coastal areas through geographical information systems
Authors: Lango-Reynoso Verónica , González-Figueroa Karla Teresa , Lango-Reynoso Fabiola , Castañeda-Chávez María del Refugio , Montoya-Mendoza Jesús 
Published: November 2020

Objective: This article describes and analyzes the main concepts of coastal ecosystems, these as a result of research concerning land-use change assessments in coastal areas.
Design/Methodology/Approach: Scientific articles were searched using keywords in English and Spanish. Articles regarding land-use change assessment in coastal areas were selected, discarding those that although being on coastal zones and geographic and soil identification did not use Geographic Information System (GIS).
Results: A GIS is a computer-based tool for evaluating the land-use change in coastal areas by quantifying variations. It is analyzed through GIS and its contributions; highlighting its importance and constant monitoring.
Limitations of the study/Implications: This research analyzes national and international scientific information, published from 2007 to 2019, regarding the land-use change in coastal areas quantified with the digital GIS tool.
Findings/Conclusions: GIS are useful tools in the identification and quantitative evaluation of changes in land-use in coastal ecosystems; which require constant evaluation due to their high dynamism.