bluuebunny/crossref_metadata_2025_split huggingface dataset:
The experiences of people bereaved by suicide regarding the press reporting of the death: qualitative study
Authors: Gregory Philip , Stevenson Fiona , King Michael , Osborn David , Pitman Alexandra 
Published: February 2020

Abstract
Background
Media guidelines on suicide reporting of suicide have two purposes: to prevent further suicides, and to minimise distress to the bereaved, who are themselves at increased risk of suicide. We aimed to describe the subjective experiences of people bereaved by suicide regarding media reporting of the suicide of their friend or relative.

Methods
We conducted a cross-sectional study of staff and students aged 18–40 at 37 United Kingdom higher educational institutions in 2010 to recruit adults who had experienced bereavement by the suicide of a close contact. We analysed free-text responses to a question probing experiences of the press after the suicide, using thematic analysis to identify key themes.

Results
We analysed responses from 140 eligible respondents, and identified 3 main themes: value placed on respecting the privacy or wishes of the bereaved; respect accorded to the deceased; and the role of the press in promoting suicide prevention messages. Many respondents described negative experiences of the press, with sub-themes capturing distressing experiences relating to perceptions of journalists’ intrusive behaviour, failure to consult appropriately with the bereaved, journalists releasing private information, negatively misrepresenting the deceased, and breaching the anonymity of the deceased or bereaved. We identified considerable variation in people’s views over acceptable levels of detail reported in the press, and in some cases objections were in relation to journalists following media guidelines. These divergent views illustrate the tensions between the twin purposes of media guidelines: to prevent further suicides, and to protect the bereaved.

Conclusions
The findings from our British sample provide journalists with personal perspectives from bereaved relatives on the impact of media intrusion, speculation, and misrepresentation, and an insight into disparate views on the nature of information relatives feel comfortable disclosing. These findings suggest a need for journalists’ training to include exposure to such views, to heighten awareness of potentially distressing effects and the nuances of bereaved people’s preferences. This should aim to encourage journalists to consult with bereaved relatives more sensitively, whilst also remaining mindful of media guidelines on the reporting of suicide.
Comprehensive assessment of computational algorithms in predicting cancer driver mutations
Authors: Chen Hu , Li Jun , Wang Yumeng , Ng Patrick Kwok-Shing , Tsang Yiu Huen , Shaw Kenna R. , Mills Gordon B. , Liang Han 
Published: February 2020

AbstractBackgroundThe initiation and subsequent evolution of cancer are largely driven by a relatively small number of somatic mutations with critical functional impacts, so-called driver mutations. Identifying driver mutations in a patient’s tumor cells is a central task in the era of precision cancer medicine. Over the decade, many computational algorithms have been developed to predict the effects of missense single-nucleotide variants, and they are frequently employed to prioritize mutation candidates. These algorithms employ diverse molecular features to build predictive models, and while some algorithms are cancer-specific, others are not. However, the relative performance of these algorithms has not been rigorously assessed.ResultsWe construct five complementary benchmark datasets: mutation clustering patterns in the protein 3D structures, literature annotation based on OncoKB, TP53 mutations based on their effects on target-gene transactivation, effects of cancer mutations on tumor formation in xenograft experiments, and functional annotation based on in vitro cell viability assays we developed including a new dataset of ~ 200 mutations. We evaluate the performance of 33 algorithms and found that CHASM, CTAT-cancer, DEOGEN2, and PrimateAI show consistently better performance than the other algorithms. Moreover, cancer-specific algorithms show much better performance than those designed for a general purpose.ConclusionsOur study is a comprehensive assessment of the performance of different algorithms in predicting cancer driver mutations and provides deep insights into the best practice of computationally prioritizing cancer mutation candidates for end-users and for the future development of new algorithms.
Oral nutritional supplements for preventing surgical site infections: protocol for a systematic review and meta-analysis
Authors: Ralph Nicholas , Brown Lindsay , McKillop Kristy L. , Duff Jed , Osborne Sonya , Terry Victoria R. , Edward Karen-Leigh , King Rachel , Barui Edward 
Published: February 2020

AbstractBackgroundSurgical site infections (SSIs) are among the most common healthcare-associated infections. Under-nutrition is an important risk factor for SSIs and can lead to delayed wound healing and longer hospital stays. Oral nutritional supplements are prescribed to reduce the risk of infection and improve health status, but data from randomised controlled trials (RCTs) have shown mixed results. Thus, the objective of our planned systematic review is to evaluate oral nutritional supplements on preventing SSIs in adult surgical patientsMethodsRCTs conducted in adult surgical patients who receive oral nutritional support will be included. The primary outcome will be the incidence of SSIs (within 30 days of surgery or within 90 days for joint replacement surgery). Secondary outcomes will be changes in nutritional status, mortality, health-related quality of life and costs. Literature searches will be conducted in several electronic databases (from inception onwards): MEDLINE, Embase, CINAHL and The Cochrane Central Register of Controlled Trials (CENTRAL). Grey literature will be identified through searching clinical trial registers and dissertation databases. Two reviewers will independently screen all citations, full-text articles and abstract data. The study methodological quality (or bias) will be appraised using the Cochrane risk of bias tool. If feasible, we will conduct random effects meta-analysis where appropriate.DiscussionThis systematic review will evaluate the evidence for pre- and post-surgical intervention with oral nutritional supplements in adults. Findings from this planned review may inform subsequent nutritional interventions for hospitalised patients who undergo surgery.Systematic review registrationPROSPEROCRD42020140954
Antibody-related movement disorders – a comprehensive review of phenotype-autoantibody correlations and a guide to testing
Authors: Gövert Felix , Leypoldt Frank , Junker Ralf , Wandinger Klaus-Peter , Deuschl Günther , Bhatia Kailash P. , Balint Bettina 
Published: February 2020

Abstract
Background
Over the past decade increasing scientific progress in the field of autoantibody–mediated neurological diseases was achieved. Movement disorders are a frequent and often prominent feature in such diseases which are potentially treatable.

Main body
Antibody-mediated movement disorders encompass a large clinical spectrum of diverse neurologic disorders occurring either in isolation or accompanying more complex autoimmune encephalopathic diseases. Since autoimmune movement disorders can easily be misdiagnosed as neurodegenerative or metabolic conditions, appropriate immunotherapy can be delayed or even missed. Recognition of typical clinical patterns is important to reach the correct diagnosis.

Conclusion
There is a growing number of newly discovered antibodies which can cause movement disorders. Several antibodies can cause distinctive phenotypes of movement disorders which are important to be aware of. Early diagnosis is important because immunotherapy can result in major improvement.
In this review article we summarize the current knowledge of autoimmune movement disorders from a point of view focused on clinical syndromes. We discuss associated clinical phenomenology and antineuronal antibodies together with alternative etiologies with the aim of providing a diagnostic framework for clinicians considering underlying autoimmunity in patients with movement disorders.
Diffusion tensor imaging: a smart move to olfactory pathway imaging; comparative study of chronic sinonasal polyposis patients and normal control
Authors: Taha Tougan , Megahed Ayah A. , Taha Mohamed Shehata , Mahmoud Heba , Rabie Tahany Mohamed , Askora Anas Mohamed 
Published: February 2020

AbstractBackgroundOlfaction is critically important for a good quality of life and incorporated in many physiological domains such as attention, emotion, memory, and airflow motor control. Olfactory researches have been expanded in the last decade due to close relation between the olfactory disorders and different brain diseases. Diagnosis of anosmia and hyposmia are based on history, smell tests, and physical examination which rely on the patient’s response without an objective measure of impairment. This study assessed the value of volumetry and DTI parameters as objective measurements for olfactory dysfunction.Fourteen patients with chronic sinonasal polyposis for at least 6 months were included in this study; all of them underwent tailored MRI examination including volumetry and DTI for olfactory bulbs and tracts. The results were compared to the same number of age and sex-matched healthy control group.ResultsThe study results showed that olfactory bulb and tract (OB/T) volume, FA and ADC could distinguish between patients and healthy controls. Statistically significant differences were noticed between the FA & ADC values of patient and control groups (p< 0.05) and a highly significant one was noticed as regarding the OT volume (p< 0.001).ConclusionMR volumetry and DTI parameters can be used as objective measurements for the olfactory dysfunction for patients with chronic sinonasal polyposis.
Long-Term Outcomes and Retreatment Among Patients With Previously Treated, Programmed Death-Ligand 1‒Positive, Advanced Non‒Small-Cell Lung Cancer in the KEYNOTE-010 Study
Authors: Herbst Roy S. , Garon Edward B. , Kim Dong-Wan , Cho Byoung Chul , Perez-Gracia Jose L. , Han Ji-Youn , Arvis Catherine Dubos , Majem Margarita , Forster Martin D. , Monnet Isabelle , Novello Silvia , Szalai Zsuzsanna , Gubens Matthew A. , Su Wu-Chou , Ceresoli Giovanni Luca , Samkari Ayman , Jensen Erin H. , Lubiniecki Gregory M. , Baas Paul 
Published: February 2020

PURPOSE In the KEYNOTE-010 study, pembrolizumab improved overall survival (OS) versus docetaxel in previously treated, programmed death-ligand 1 (PD-L1)‒expressing advanced non‒small-cell lung cancer (NSCLC) in patients with a tumor proportion score (TPS) ≥ 50% and ≥ 1%. We report KEYNOTE-010 long-term outcomes, including after 35 cycles/2 years or second-course pembrolizumab. METHODS Of 1,033 patients randomly assigned (intention to treat), 690 received up to 35 cycles/2 years of pembrolizumab 2 mg/kg (n = 344) or 10 mg/kg (n = 346) every 3 weeks, and 343 received docetaxel 75 mg/m2 every 3 weeks. Eligible patients with disease progression after 35 cycles/2 years of pembrolizumab could receive second-course treatment (up to 17 cycles). Pembrolizumab doses were pooled because no between-dose difference was observed at primary analysis. RESULTS Pembrolizumab continued to improve OS over docetaxel in the PD-L1 TPS ≥ 50% and ≥ 1% groups (hazard ratio [HR], 0.53; 95% CI, 0.42 to 0.66; P < .00001; and HR, 0.69; 95% CI, 0.60 to 0.80; P < .00001, respectively) after a 42.6-month (range, 35.2-53.2 months) median follow-up. Estimated 36-month OS rates were 34.5% versus 12.7% and 22.9% versus 11.0%, respectively. Grade 3-5 treatment-related adverse events occurred in 16% versus 37% of patients, respectively. Seventy-nine of 690 patients completed 35 cycles/2 years of pembrolizumab; 12-month OS and progression-free survival rates after completing treatment were 98.7% (95% CI, 91.1% to 99.8%) and 72.5% (95% CI, 59.9% to 81.8%), respectively. Seventy-five patients (95%) had objective response (RECIST v1.1, blinded independent central review) and 48 (64%) had ongoing response. Grade 3-5 treatment-related adverse events occurred in 17.7% of patients. Fourteen patients received second-course pembrolizumab: 5 completed 17 cycles, 6 (43%) had partial response, and 5 (36%) had stable disease. CONCLUSION Pembrolizumab provided long-term OS benefit over docetaxel, with manageable safety, durable responses among patients receiving 2 years of treatment, and disease control with second-course treatment, further supporting pembrolizumab for previously treated, PD-L1‒expressing advanced NSCLC.
A hemispheric comparison of cognitive dysfunction and sleep quality impairment in Middle Cerebral Artery infarction
Authors: Wahid Danyal , Rabbani Hifza , Inam Ayesha , Akhtar Zuba'a 
Published: February 2020

Objectives: To investigate the severity of cognitive dysfunction and sleep quality impairment in patients with middle cerebral artery (MCA) strokes across the left and right hemisphere. Moreover, it also study gender differences with respect to MCA strokes.
Methods: The study was conducted from February 2019 - May 2019 at COMSATS University, Islamabad. A total sample size of N=55 middle cerebral artery ischemic infarct patients was selected with N=29 left middle cerebral artery ischemic infarct patients and N=26 right middle cerebral artery ischemic infarct patients. The sample was assessed on The Neurocognitive Assessment Battery for stroke patients (N-CABS) & The Pittsburgh Sleep Quality Index-Urdu (PSQI-U).
Results: The mean age of the sample was 50.96 years. There was a significant difference among scores of cognitive dysfunction between Left MCA (M=47.28, SD=12.87) and Right MCA stroke patients (M=29.7, S=21.41), t (53) =-6.80, p<0.001. Similarly, there was significant difference among scores of sleep disturbance between Left MCA (M=6.90, SD=2.93) and Right MCA (M=10.35, SD=3.97), t (53) =-3.68, p<0.001. Gender comparisons reveal that there is no significant difference between males and females for both, cognitive dysfunction and sleep quality impairment.
Conclusions: Cognitive dysfunction and sleep quality impairment due to MCA strokes is significant between left and right hemispheres respectively, regardless of gender, assessed with N-CABS and PSQI-U. Further studies are required to analyse other demographic correlates related to MCA strokes.
doi: https://doi.org/10.12669/pjms.36.3.1385
How to cite this:Wahid D, Rabbani H, Inam A, Akhtar Z. A hemispheric comparison of cognitive dysfunction and sleep quality impairment in Middle Cerebral Artery infarction. Pak J Med Sci. 2020;36(3):511-515. doi: https://doi.org/10.12669/pjms.36.3.1385
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
UM BREVE ENSAIO SOBRE A MASCULINIDADE HEGEMÔNICA
Authors: Rodriguez Shay De los Santos 
Published: February 2020

O seguinte texto tem o intuito de problematizar em um âmbito da arqueologia de gênero e queer, a masculinidade hegemônica, que agride com as suas práticas e gera resultados terríveis. Para isso, foi necessário discorrer sobre quem pertence ao modelo hegemônico e quem não pertence e assim elaborar maneiras de acabar com a masculinidade tóxica que afeta todas as pessoas.
ENTRELAÇANDO MASCULINIDADES E JUVENTUDES NO PORTAL DE PERIÓDICOS CAPES ENTRE 2000 E 2017
Authors: Oliveira Francis Fonseca , Santos Claudiene 
Published: February 2020

Estudos masculinistas são estudos de matriz feminista sobre masculinidades, que analisam as relações de gênero e suas interseccionalidades, problematizando posições masculinas e normas hegemônicas-homofóbicas-misóginas. Analisamos como masculinidades e juventudes são enunciadas nas produções científicas, por meio de estado da arte de artigos no Portal de Periódicos CAPES, entre 2000- 2017. Houve crescente discussão dos estudos sobre jovens homens no Brasil e na América Latina, com produções, majoritariamente, nas ciências humanas e sociais. As 176 publicações encontradas foram discutidas em seis categorias, articulando os estudos de gênero na construção das identidades masculinas a diversas instâncias sociais, palco para legitimação ou processos de ruptura da masculinidade hegemônica. Os trabalhos encontrados refletem discussões interseccionais sobre (re)produções discursivas da masculinidade hegemônica que, performativamente, fabricam hierarquizações sociais. As múltiplas identidades masculinas juvenis e suas articulações nesses trabalhos, mostram que há uma produção de estudos de matriz feminista na discussão sobre a pluralidade das masculinidades juvenis.
Marki kolońskie czy liwry francuskie, czyli o finansowaniu i przelicznikach walutowych podczas IV wyprawy krzyżowej, w świetle umowy z kwietnia 1201 roku oraz kronik Geoffroy’a de Villehardouin i Roberta z Clari
Authors: Pentek Zdzisław 
Published: February 2020

Artykuł dotyczy finansowania IV krucjaty oraz umowy przyszłych przywódców krucjaty z Wenecją zawartej w kwietniu 1201 roku. Poruszono kwestie przeliczników walutowych marki kolońskiej i liwrów francuskich, o których piszą kronikarze Robert z Clari i Geoffroy de Villehardouin. Ustalono, że podana przez Roberta z Clari kwota zapłacona przez krzyżowców Wenecji opiewająca na 50 tys. liwrów jest niezgodna z realiami. W rzeczywistości było to 50 tys. marek kolońskich, które miały znacznie mniejszą wartość. Gdyby to były liwry francuskie wystarczyłyby one na pokrycie całej kwoty, którą krzyżowcy zobowiązali się zapłacić, bowiem 50 tys. liwrów było wówczas równe 20 450 kg srebra, a cała suma, jaką krzyżowcy zobowiązali się opiewała na 85 tys. marek kolońskich, czyli 19 890 kg srebra. Tymczasem wiadomo, że po zapłaceniu owych 50 tys. i dodatkowego tysiąca zebranego przez żołnierzy pozostał jeszcze dług 34 tys. marek kolońskich, które krzyżowcy musieli odpracować na służbie weneckiej. Organizatorzy IV krucjaty znacznie przeszacowali liczbę przyszłych jej uczestników i zawarli umowę z Wenecją znacznie na wyrost, zamawiając budowę floty i prowiant na czas jednego roku dla zbyt dużej liczby uczestników wyprawy. W rezultacie ci, którzy stawili się na wyprawę, nie byli w stanie pokryć ogromnych jej kosztów.
Debt Crisis and Learning – Replying to Two Stimulating Reviews
Authors: Bohoslavsky Juan Pablo , Raffer Kunibert 
Published: February 2020

Abstract
This piece tackles Barrio Arleo and Lienau’s comments on Sovereign Debt Crises: What Have We Learned? while tries to further develop some ideas and discussions proposed in the book. This piece deals with existing alternatives to overcome debt crises, the link between sovereign policy space and the principle of creditors’ equal treatment, who the target of the book is (and should be), whether “learning is enough”, and the potential policy and legal role of human rights law in debt restructurings.
On the stability of k-Hessian overdetermined and partially overdetermined problems in planar domain
Authors: Zhao Lingling , Li Fengquan 
Published: February 2020

Abstract
In this paper, we study the stability of k-Hessian overdetermined problems under small perturbations in

R
2

{R^{2}}

. Additionally, we give a proof for k-Hessian partially overdetermined problems and the related stability problems in

R
2

{R^{2}}

. The proof mainly replies to choosing a suitable auxiliary f.
Aplasia cutis congenita as a consequence of fetal reduction in a triplet pregnancy
Authors: Clemente Maria , Perazzolli Gabriele , Tadiotto Elisa , Pecoraro Luca , Schena Donatella , Pietrobelli Angelo 
Published: February 2020

Abstract

Background
Aplasia cutis congenita (ACC) is a rare skin disorder characterized by a localized absence of skin at birth. It has been linked to both assisted reproductive technology (ART) and feto-reduction procedures. Group V ACC presents with a distinct, symmetrical distribution pattern. It is thought to result from an insult to the fetus after concomitant twin demise and is almost exclusively reported in monochorionic gestations.

Case presentation
We report a rare case of Group V ACC in a dichorionic, triamniotic (di-Tri) triplet in-vitro fertilization (IVF) pregnancy subsequent to feto-reduction. The lesions were managed conservatively.

Conclusion
ACC in multi-fetal pregnancies is a rare, but widely described complication. With increased incidence of ART-associated pregnancies and the use of feto-reduction for multiple pregnancies, this may become a more common phenomenon. Neonatologists and obstetricians should be aware of this complication and counsel their feto-reduction patients on the risks. This case is interesting because, to the best of our knowledge, there have been only nine reported cases of Group V ACC in triplet or higher order gestations.
Drivers ’reaction time research in the conditions in the real traffic
Authors: Droździel Paweł , Tarkowski Sławomir , Rybicka Iwona , Wrona Rafał 
Published: February 2020

Abstract
The article presents the results of research on the total reaction time of drivers in real traffic conditions. The tested driver had to react to a complex signal by performing a braking manoeuvre. The measurements were based on the author’s method combining the measurements of reaction time during the actual driving with their computer analysis. The research group consisted of 15 drivers with different seniority of driving licences. The study measured the time of perception and the time of leg transfer from the accelerator pedal to the brake pedal. The results were subjected to analysis and on its basis conclusions were formulated.
Evaluating a University Entrepreneurial Programme in a Developing Country: Applying Rasch Measurement Theory to Attitude to Enterprise
Authors: Gil-Soto Esperanza , Oreja-Rodriguez Juan R. , García-Rodríguez Francisco J. , Ruiz-Rosa Inés 
Published: February 2020

Abstract
This paper examines the impact of an educational programme developed in Senegal with university students and designed to encourage entrepreneurship by influencing personal attitudes toward enterprise. The instrument to measure the entrepreneurial potential of young people has been applied in different socio-demographic contexts in some previous empirical research. Improvements in students’ perception of attitudinal factors associated with leadership, creativity, achievement and intuition can be inferred from the results of the longitudinal analysis conducted. Moreover, a positive and significant relationship between students’ perceived behavioural control and their attitudes toward starting a business at the end of the entrepreneurial programme is confirmed. Rasch Measurement Theory is applied to analyse the validity of the measurements and findings suggest that the scale used seems to be a reliable and valid tool for measuring entrepreneurial attitude in a university setting. Results confirm that entrepreneurship programmes have the potential to improve the entrepreneurial attitudes of students in a developing country.