bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta-analysis of interventions to reduce door to needle times in acute ischaemic stroke patients
Authors: Siarkowski Michael , Lin Katie , Li Shari S , Al Sultan Abdulaziz , Ganshorn Heather , Kamal Noreen , Hill Michael , Lang Eddy 
Published: August 2020

BackgroundDoor-to-needle time (DTN) has an important impact on thrombolysis and reperfusion outcomes in the treatment of acute ischaemic stroke. This systematic review is a critical synthesis of studies evaluating DTN reduction strategies.MethodOvid MEDLINE, PubMed, Cochrane Database of Systematic Reviews, CINAHL, ProQuest dissertations and LILACS were used as bibliographic databases for primary literature. CIHI, Health Quality Council of Alberta, Health Quality Ontario and websites of heart and stroke associations in Canada, USA, UK, Australia and New Zealand were used as sources of grey literature. Searched reports were screened by title and abstract, and full texts were located for review. Articles quality was evaluated using National Institute of Health’s Study Quality Assessment tools. Methods for improving DTN were categorised under 13 DTN reduction strategies, primarily adapted from the Target: Stroke Phase II recommendations, and including two additional categories: Strategies not encompassed by any Target: Stroke recommendation, and Combinations of Interventions.Results96 studies (4 randomised control trials, 1 review, 91 observational pre/post studies) were included in the review. All strategies and interventions resulted in a reduction of DTN. Approaches using combinations of interventions were the most effective at reducing DTN (33.77% DTN reduction, standard mean difference=1.857, 95% CI=1.510–2.205), and were more effective than approaches using only a single strategy (p=0.040). DTN reduction was associated with the duration of the DTN reduction programme at each facility (p=0.006).InterpretationThe greatest reductions in DTN were observed when implementing combinations of DTN reduction strategies, although there was no significant advantage to implementing more than two strategies simultaneously.PROSPERO registration number42016036215.
Assessment of hepatitis and fibrosis using Gd‐EOB‐DTPA MRI in dogs
Authors: Tanaka Toshiyuki , Nishida Hidetaka , Mie Keiichiro , Yamazaki Hiroki , Lin Lee‐Shuan , Akiyoshi Hideo 
Published: August 2020

BackgroundGadoxetate sodium (Gd‐EOB‐DTPA) is taken into hepatocytes and excreted into the bile. Hepatocytes with reduced function or dysfunction due to hepatocellular carcinoma (HCC), hepatitis or hepatic fibrosis show impaired Gd‐EOB‐DTPA uptake. The purpose of the present retrospective case series was to assess the relationship between liver function and contrast enhancement using Gd‐EOB‐DTPA MRI.MethodsSixteen dogs with a histopathological diagnosis of liver disease, including six with HCC, three with nodular hyperplasia, two with hepatocellular adenoma, two with liver fibrosis and three with hepatitis were included in the study along with three dogs with suspected liver disease but no histopathological diagnosis of liver disease. Relative signal intensities (RSI) of the common bile duct and gall bladder were calculated, and their relationship with the following serum biochemical parameters was assessed: total bilirubin, alanine transaminase, alkaline phosphatase and albumin (Alb). To assess anatomical liver function, relative contrast enhancement indices (RCEI) of the liver were calculated, and differences were assessed between normal and diseased liver.ResultsRSI showed no significant differences between dogs without and with a histopathological diagnosis of liver disease (P=0.88) although they were significantly correlated with Alb (ρ =0.57, P=0.02) in dogs with a histopathological diagnosis of liver disease. RCEI was significantly higher in normal liver tissue than that in livers with hepatitis/fibrosis (P=0.048) and HCC (P=0.03) but not nodular hyperplasia/hepatocellular adenoma (P=0.51).ConclusionsGd‐EOB‐DTPA MRI may be potentially useful in the assessment of anatomical liver function in dogs with liver disease.
First observation of a tau neutrino charged current interaction with charm production in the OPERA experiment
Authors: Agafonova N. , Aleksandrov A. , Anokhina A. , Aoki S. , Ariga A. , Ariga T. , Bertolin A. , Bozza C. , Brugnera R. , Buonaura A. , Buontempo S. , Chernyavskiy M. , Chukanov A. , Consiglio L. , D’Ambrosio N. , De Lellis G. , De Serio M. , del Amo Sanchez P. , Di Crescenzo A. , Di Ferdinando D. , Di Marco N. , Dmitrievski S. , Dracos M. , Duchesneau D. , Dusini S. , Dzhatdoev T. , Ebert J. , Ereditato A. , Fini R. A. , Fornari F. , Fukuda T. , Galati G. , Garfagnini A. , Gentile V. , Goldberg J. , Gorbunov S. , Gornushkin Y. , Grella G. , Guler A. M. , Gustavino C. , Hagner C. , Hara T. , Hayakawa T. , Hollnagel A. , Ishiguro K. , Iuliano A. , Jakovcic K. , Jollet C. , Kamiscioglu C. , Kamiscioglu M. , Kim S. H. , Kitagawa N. , Klicek B. , Kodama K. , Komatsu M. , Kose U. , Kreslo I. , Laudisio F. , Lauria A. , Longhin A. , Loverre P. , Malgin A. , Malenica M. , Mandrioli G. , Matsuo T. , Matveev V. , Mauri N. , Medinaceli E. , Meregaglia A. , Mikado S. , Miyanishi M. , Mizutani F. , Monacelli P. , Montesi M. C. , Morishima K. , Muciaccia M. T. , Naganawa N. , Naka T. , Nakamura M. , Nakano T. , Niwa K. , Okateva N. , Ogawa S. , Ozaki K. , Paoloni A. , Paparella L. , Park B. D. , Pasqualini L. , Pastore A. , Patrizii L. , Pessard H. , Podgrudkov D. , Polukhina N. , Pozzato M. , Pupilli F. , Roda M. , Roganova T. , Rokujo H. , Rosa G. , Ryazhskaya O. , Sato O. , Schembri A. , Shakirianova I. , Shchedrina T. , Shibuya H. , Shibayama E. , Shiraishi T. , Simone S. , Sirignano C. , Sirri G. , Sotnikov A. , Spinetti M. , Stanco L. , Starkov N. , Stellacci S. M. , Stipcevic M. , Strolin P. , Takahashi S. , Tenti M. , Terranova F. , Tioukov V. , Vasina S. , Vilain P. , Voevodina E. , Votano L. , Vuilleumier J. L. , Wilquet G. , Yoon C. S. 
Published: August 2020

AbstractAn event topology with two secondary vertices compatible with the decay of short-lived particles was found in the analysis of neutrino interactions in the OPERA target. The observed topology is compatible with tau neutrino charged current (CC) interactions with charm production and neutrino neutral current (NC) interactions with $$c\overline{c}$$cc¯ pair production. However, other processes can mimic this topology. A dedicated analysis was implemented to identify the underlying process. A Monte Carlo simulation was developed and complementary procedures were introduced in the kinematic reconstruction. A multivariate analysis technique was used to achieve an optimal separation of signal from background. Most likely, this event is a $$\nu _{\tau }$$ντ CC interaction with charm production, the tau and charm particle decaying into 1 prong and 2 prongs, respectively. The significance of this observation is evaluated.
Discrete Adaptive Responses to MEK Inhibitor in Subpopulations of Triple-Negative Breast Cancer
Authors: Goulet Daniel R. , Foster Joseph P. , Zawistowski Jon S. , Bevill Samantha M. , Noël Mélodie P. , Olivares-Quintero José F. , Sciaky Noah , Singh Darshan , Santos Charlene , Pattenden Samantha G. , Davis Ian J. , Johnson Gary L. 
Published: August 2020

Abstract

Triple-negative breast cancers contain a spectrum of epithelial and mesenchymal phenotypes. SUM-229PE cells represent a model for this heterogeneity, maintaining both epithelial and mesenchymal subpopulations that are genomically similar but distinct in gene expression profiles. We identified differential regions of open chromatin in epithelial and mesenchymal cells that were strongly correlated with regions of H3K27ac. Motif analysis of these regions identified consensus sequences for transcription factors that regulate cell identity. Treatment with the MEK inhibitor trametinib induced enhancer remodeling that is associated with transcriptional regulation of genes in epithelial and mesenchymal cells. Motif analysis of enhancer peaks downregulated in response to chronic treatment with trametinib identified AP-1 motif enrichment in both epithelial and mesenchymal subpopulations. Chromatin immunoprecipitation sequencing (ChIP-seq) of JUNB identified subpopulation-specific localization, which was significantly enriched at regions of open chromatin. These results indicate that cell identity controls localization of transcription factors and chromatin-modifying enzymes to enhancers for differential control of gene expression. We identified increased H3K27ac at an enhancer region proximal to CXCR7, a G-protein–coupled receptor that increased 15-fold in expression in the epithelial subpopulation during chronic treatment. RNAi knockdown of CXCR7 inhibited proliferation in trametinib-resistant cells. Thus, adaptive resistance to chronic trametinib treatment contributes to proliferation in the presence of the drug. Acquired amplification of KRAS following trametinib dose escalation further contributed to POS cell proliferation. Adaptive followed by acquired gene expression changes contributed to proliferation in trametinib-resistant cells, suggesting inhibition of early transcriptional reprogramming could prevent resistance and the bypass of targeted therapy.

Implications:
We defined the differential responses to trametinib in subpopulations of a clinically relevant in vitro model of TNBC, and identified both adaptive and acquired elements that contribute to the emergence of drug resistance mediated by increased expression of CXCR7 and amplification of KRAS.
Optimized output-based input shaping for control of single-link flexible manipulator using linear matrix inequality
Authors: Musa Tahir Nura , Muhammad Mustapha , Bala Muhammad Bashir , Liman Haliru , Yahaya Zimit Aminu , Shehu Tijjani Auwal 
Published: August 2020

<span>Precise hub angle positioning due to tip deflections, flexible motions and under various payloads is enormous tasks in the control of single-link flexible manipulators. In this paper, output-based command shaping (OBCS) was designed using the system output for tip deflections and residuals vibrations suppression, and this was incorporated with a linear matrix inequality (LMI) closed-loop control scheme for precise hub angle positioning. The robustness of the hybrid control scheme was tested by changing the payloads from 0g to 30g, and 50g. Simulation results showed that endpoint residuals vibrations and tip deflections due to flexible motions were suppressed and hence precise hub angle positioning under various payloads was achieved. Integral absolute error (IAE), Integral square error (ISE) and Time response analysis (TRA) were used as the performance indexes. Hence, the hybrid control scheme is simple and robust.</span>
A coplanar waveguide tapered slot antenna with beam switching capabilities
Authors: Abijuru Delphine , R. Hamid M. , Seman N. , Himdi M. 
Published: August 2020

<p>A wideband tapered slot antenna (TSA) with three radiating elements for beam switching purpose is proposed in this study. The integrated radiating taper slots in assistance with metal strips acting as switches provided the proposed design with the capability of switching its beam into three different directions while maintaining the antenna performance stable. To validate the accuracy of the proposed design, the prototype was fabricated and measurements were conducted in terms of reflection coefficient (S11), radiation pattern and realized gain towards the three different operating modes. By sequentially, activating the switches, the antenna main beam rotated 90º in the XY coordinates. A realized gain ranging from 4.3 to 6.4 dBi and a wide operating bandwidth (|S11| ≤-10dB) from 3.3 GHz to 5 GHz were observed throughout the antenna performance in simulation as well as in experiment. With the covered bands, the proposed antenna can be suitable for Sub -6GHz wireless communications systems. Improvements of Trapezoid Antenna Gain using Artificial Magnetic Conductor and Frequency Selective Surface.</p>
Image encryption scheme in public key cryptography based on cubic pells quadratic case
Authors: K. R. Raghunandan , Aithal Ganesh , Shetty Surendra , K. Bhavya 
Published: August 2020

Cryptography systems face new threats with the transformation of time and technology. Each innovation tries to contest challenges posed by the previous system by analyzing approaches that are able to provide impressive outcomes. The prime aim of this work is to urge ways in which the concept of Pell’s equation can be used in Public key Cryptography techniques.The main aim of this approach is secure and can be computed very fast. Using Cubic Pell’s equation defined in Quadratic Case, a secure public key technique for Key generation process is showcased. The paper highlights that a key generation time of proposed scheme using Pell’s Quadratic case equation is fast compared to existing methods.The strength and quality of the proposed method is proved and analyzed by obtaining the results of entropy, differential analysis, correlation analysis and avalanche effect. The superiority of the proposed method over the conventional AES and DES is confirmed by a 50% increase in the execution speed and shows that Standard diviation and Entropy analysis of proposed scheme gives immunity to guess the encryption key and also it is hard to deduce the private key from public key using Diffrential analysis.
Analysis on the behavior of line differential protective relaying with solar PV penetration
Authors: E. Yusoff M. , Hashim H. 
Published: August 2020

Power System Protection is very important in electrical power system as it minimizes power supply interruption to customers, and also prevents damages to electrical equipment. Lately, renewable energy (RE) penetration in power system helps to support and fulfil the increasing demand of electricity to customers. However, the contribution of power from RE such as solar photovoltaic (PV) will increase the fault level and lead to reverse power flow; thus, it will affect power system protection reliability. This paper focuses on evaluating the reliability of differential protection relay during steady state, internal and external faults conditions when the power system is without and with solar PV penetration. Steady state and three-phase symmetrical line fault will be simulated in IEEE 39 bus test system using Power System Simulation for Engineering (PSS<sup>®</sup>E) software.
FIBR-OSS: fault injection model for bug reports in open-source software
Authors: Abdulameer Alazawi Sundos , Al-Salam Mohammed Najim 
Published: August 2020

<span>For assessment of system dependability, fault injection techniques are used to expedite the presence of an error or failure in the system, which helps evaluate fault tolerance and system failure prediction. Defects classification and prediction is the principal significant advance in the trustworthiness evaluation of complex software systems such as open-source software since it can quickly be affected by the reliability of those systems, improves performance, and lessening the product cost. In this context, a new prototype of the fault injection model is presented, FIBR-OSS (Fault Injection for Bug Reports in Open-Source Software). FIBR-OSS can support developers to evaluate the system performance during phase's development for its dependability attributes such as reliability and system dependability means such as fault prediction or forecasting. FIBR-OSS is used for fault speed-up to test the system's failure prediction performance. Some machine learning techniques are implemented on bug reports produced existing by the bug tracking system as datasets for failure prediction techniques, some of those machine learning techniques are used in our approach.</span>
Cryptosystems using an improving hiding technique based on latin square and magic square
Authors: Mohammed Sahab Dheyaa , Hasan Taha Mohammed 
Published: August 2020

<p>Hackers should be prevented from disclosing sensitive data when sent from one device to another over the network. Therefore, the proposed method was established to prevent the attackers from exploiting the vulnerabilities of the redundancy in the ciphertext and enhances the substitution and permutation operations of the encryption process .the solution was performed by eliminates these duplicates by hiding the ciphertext into a submatrix 4 x4 that chooses randomly from magic square 16x16 in each ciphering process. Two techniques of encrypted and hiding were executed in the encryption stage by using a magic square size 3 × 3 and Latin square size 3 × 3 to providing more permutation and also to ensure an inverse matrix of decryption operation be available. In the hiding stage, the ciphertext was hidden into a 16×16 matrix that includes 16 sub-magic squares to eliminate the duplicates in the ciphertext. Where all elements that uses were polynomial numbers of a finite field of degree Galois Fields GF ( ). The proposed technique is robust against disclosing the repetition encrypted data based on the result of Avalanche Effect in an accepted ratio (62%) and the results of the output of the proposed encryption method have acceptable randomness based on the results of the p-values (0.629515) of the National Institute of Standards and Technology (NIST) randomness tests. The work can be considered significant in the field of encrypting databases because the repetition of encrypted data inside databases is considered an important vulnerability that helps to guess the plaintext from the encrypted text.</p>
Improved cloud data transfer security using hybrid encryption algorithm
Authors: Zaineldeen Samar , Ate Abdelrahim 
Published: August 2020

Cloud computing is a model of sophisticated computing which has a strong effect on data innovation. Cloud computing offers remote access to shared computerized assets in the stored cloud. Operationally cloud servers utilize Web services that give enormus advantage to the user in a variety of applications such as banking and finance, storage, social networking and e-mail. Cloud computing accomplishes many of the features interrelated to elasticity, ease of utility, efficiency and performance with low cost. There are a number of potential concerns related to security and privacy since the requirement to protect cloud computing expanded, the encryption algorithms play the key part in data and information security systems, on side these algorithms consume a considerable quantity of computing resource.This paper,presenting a new hybrid encryption algorithm emphasising on AES and Enhanced Homomorphic Cryptosystem (EHC) as a hybrid encryption to guarantee the secure exchange of data between the user and the cloud server, and compression study for two proficient homomorphic encryption techniques for encoding Data Encryption Standard (DES), Advance Encryption Stander (AES).With The proposed techniques an evaluation has been conducted for those encryption algorithms at diverse file sizes of data, to evaluate time taking for encryption and decryption, throughput, memory consumption and power consumption. The major finding was thats the proposed method has the extremity throughput; memory consumption and our proposed work took advantage of the least time taken in sec for encryption and decryption.
An efficient hybrid model for secure transmission of data by using efficient data collection and dissemination (EDCD) algorithm based WSN
Authors: Mahmood Akawee Mustafa , Meteab Al-Obaidi Mohanad Ali , Turki Al-Hilfi Haider Mohammed , Jassim Sabbar Insaif , Sutikno Tole 
Published: August 2020

<span>Wireless Sensor Network (WSN) is one of the most important elements of the Internet of Things paradigm. Energy consumption is a vital issue in IoT and WSN. Security primitives in the IoT are energy consuming. Addressed the security issue for transmitted data by IoT sensor node add another challenge in term of energy consumption. finding the satisfactory solutions that reduce power consumption at the same time as making sure the required security services is not always an easy undertaking. Therefore, in this article, we proposed an efficient hybrid model for secure transmission of data from sensor nodes to receivers in WSN applications. The proposed model includes two algorithms Rivest–Shamir–Adleman (RSA) and efficient data collection and dissemination (EDCD). The key idea behind the proposed model is to prevent to secure sensed data if no significant change between the current data and the last transmitted data by the apply EDCD1 algorithm, which that will help in saving the sensor node energy. The reason for that the size of cipher data is so large compared to the sensed data, which that will increase the energy consumption. The outcome results shown that the proposed model has a high performance compared to RSA in term of energy consumption.</span>
Zinc oxide-paper based sensor for photoconductive ultraviolet detection
Authors: Che Soh Mohammad Shafiq , Zainal Abidin Mastura Shafinaz , Abd Rahman Shaharin Fadzli , Elangkovan Shuthish , Md Rashid Ahmad Bukhairi 
Published: August 2020

Paper based sensor is the new technology to fabricate a simple, portable, and low cost device that exhibits the comparable properties and functions with those fabricated using complex fabrication process. Paper based sensor is usually applied in environmental monitoring, health diagnostics, and food quality control. This research is focusing on the paper based sensor that will contribute to the development of Ultraviolet (UV) sensor. The fabrication of the sensor was done by using different grade of pencil, namely 6B and 2B on different type of paper. The different grade of pencil corresponds to different percentage of graphite and clay. As for the type of paper, A4 printing paper and Whatman filter paper were used. UV sensing operation was analyzed from the measurement of current-voltage (I-V) characteristics under the exposure of UV light. Zinc oxide (ZnO) was coated on the sensor to facilitate the detection in the presence of UV. The sample fabricated using 6B pencil grade on A4 printing paper and with ZnO coating showed a better UV sensing performance compared to other samples. This is due to the high conduction of 6B pencil grade and smooth surface of A4 printing paper. The ZnO coating increased the sensor sensitivity and response towards the UV light. These findings provide valuable information which can be used in fabricating a low-cost and simple UV paper sensor.
Online social network relationships influenced on a retweeting
Authors: Abbood Iman K. , Talib Hasson Saad 
Published: August 2020

<p>Social network users spending a lot of time to post, search, interact and read the news on blogging platforms. In this era, social media is becoming a suitable place for discovering and exchanging new updates. However, Common social media helps the user to share his news online by a one-click. The ease-of-use leads to present novel breaking news to show up first on micro blogs. Twitter is one of the well-known micro blogging platforms with more than 250 million users, in which retweeting is a manageable way to share and sawing news. It is significant to foretell the retweeting and influence in a social relationship. The Correlation Coefficient formula has been used to determine the level of correlation between a user and his retweeters (followers, friends, and strangers) in social networks. Such correlation can be reached by utilizing the collected user information on Twitter with some features which have a main effect on retweet behavior. In this study, the focus is on particular friends, followers, and a retweet to be the promising source of relationships between users of social media. Experimental results based on twitter dataset showed that the Correlation Coefficient formula can be used as a predicting model, and it is a general framework to gain better fulfillment in calculating the correlation between the user, friends, and followers in social networks.. Their influence on the accuracy in predicting a retweet is also accomplished.</p>