bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geomorphology of a modern carbonate slope system and associated sedimentary processes: Example of the giant Great Abaco Canyon, Bahamas
Authors: Recouvreur Audrey , Fabregas Natacha , Mulder Thierry , Hanquiez Vincent , Fauquembergue Kelly , Tournadour Elsa , Gillet Hervé , Borgomano Jean , Poli Emmanuelle , Kucharski Jean‐Baptiste , Wilk Stanislas 
Published: July 2020

AbstractThe large acoustic data set acquired during the Carambar cruises is composed of high resolution bathymetry, backscatter data and very‐high resolution seismic lines which allow for an overview of the morphology and sediment transfer processes from the shallow upper slope to the abyssal plain of a modern carbonate system: the north‐eastern slope of the Little Bahama Bank. Surficial distribution of the acoustic facies and echofacies reflects a wide variety of sedimentary processes along and across the slope. The western sector of the Little Bahama Bank is dominated by depositional processes whereas its eastern sector, which is incised in the lower slope by giant canyons, is affected by erosion and bypass processes. Datasets suggest that currents play an important role both in along‐slope sedimentary processes and in the abyssal plain. The Antilles Current appears to affect a large part of the middle and lower slopes. The absence of sizeable present‐day channel/levée complexes or lobes at the mouth of the canyon – revealed by the bathymetric map – indicates that the southward flowing Deep Western Boundary Current influences modern abyssal sediment deposition. Based on depositional processes and indicators of canyon maturity observed in facies distribution, the current study proposes that differential subsidence affects the eastern versus western part of the bank. The morphology of the Great Abaco Canyon and Little Abaco Canyon, which extend parallel to the platform, and the Little Bahama Bank slope appears to be related to the Great Abaco Fracture Zone.
Gestión del conocimiento en el marco de la innovación en la Facultad de Ciencias Juridicas de la Universidad de Manizales: Auditoria de conocimiento
Authors: González Carreño Camilo , Montoya Escobar Mónica Cecilia 
Published: July 2020

El aporte a la optimización de la gestión del conocimiento en el Programa de Derecho de la Facultad de Ciencias Jurídicas de la Universidad de Manizales, emerge como interés primordial en este estudio y puede evidenciarse a través de la formulación de un plan de acción diseñado por los autores, luego de determinar el estado de la gestión del conocimiento de dicho programa mediante la implementación de una metodología de auditoría del conocimiento basada en el enfoque de los procesos clave de la organización. Se desarrolla bajo un enfoque empírico-analítico, cuyo nivel de análisis se identificó en dos momentos: descriptivo y propositivo, este último consistió en el plan de acción como aporte a la planeación estratégica. El plan de acción está compuesto de acciones de mejora ubicadas estratégicamente de acuerdo a los procesos de la gestión del conocimiento: adquisición, difusión y aplicación, pero también enmarcadas en la innovación educativa. El surgimiento de las acciones de mejora se dio a partir de las brechas de conocimiento existentes y detectadas. Su análisis con ánimo propositivo, permitió con este estudio, contribuir a la planificación estratégica del programa con miras a sostener los estándares de calidad misional con los que se identifica.
A Simple Frequency Range Selector to Reduce the Unstable Behavior of Active Vibration Isolation
Authors: La Viet Duc 
Published: July 2020

Abstract
In an active vibration isolation system using velocity feedback, the phase–lead due to high-pass filter and the phase–lag due to time delay limit the controller gain. This paper extends and applies a simple frequency range selector to increase the critical control gain. The selector uses the isolated mass's acceleration, velocity, and displacement and is tuned by two knobs. Our proposed approach has simple static switching law, suppresses both low and high frequency control, and does not add additional phase–lead or phase–lag. A simple expression of the effective gain is presented to give insight into the influence of two tuning knobs. Numerical simulations and a simple experiment are performed to illustrate the controller's effectiveness under harmonic and random disturbances.
Single Robust Proportional-Derivative Control for Friction Compensation in Fast and Precise Motion Systems With Actuator Constraint
Authors: Zheng Chunhong , Su Yuxin , Mercorelli Paolo 
Published: July 2020

Abstract
This paper revisits the problem of global asymptotic positioning of uncertain motion systems subject to actuator constraint and friction. A simple model-free saturated control is proposed by incorporating a relay term driven by position error into proportional-derivative (PD) methodology. Lyapunov's direct method is employed to prove global asymptotic positioning stability. The appealing advantages of the proposed approach are that it is conceived within the framework of saturated PD (SPD) control methodology with intuitive structure and absence of modeling parameter and embeds the whole control action within a single saturation function. Benefitted from these advantages, the proposed approach omits the complicated discrimination of the terms that shall be bounded in several saturation functions of the commonly used design and permits easy implementation with an improved performance. An additive feature is that the proposed control has the ability to ensure that the actuator constraint is not breached and assures global asymptotic positioning stability in the presence of unknown friction. Numerical simulations and experimental validations demonstrate the effectiveness and improved performance of the proposed approach. The proposed approach provides a model-free solution for fast transient and high-precision steady-state positioning of uncertain motion systems subject to unknown friction and actuator constraint.
Recommended physical activity and all cause and cause specific mortality in US adults: prospective cohort study
Authors: Zhao Min , Veeranki Sreenivas P , Magnussen Costan G , Xi Bo 
Published: July 2020

AbstractObjectiveTo determine the association between recommended physical activity according to the 2018 physical activity guidelines for Americans and all cause and cause specific mortality using a nationally representative sample of US adults.DesignPopulation based cohort study.SettingNational Health Interview Survey (1997-2014) with linkage to the National Death Index records to 31 December 2015.Participants479 856 adults aged 18 years or older.ExposuresParticipant self-reports of the amount of leisure time spent in aerobic physical activity and muscle strengthening activity each week were combined and categorised into four groups: insufficient activity, aerobic activity only, muscle strengthening only, and both aerobic and muscle strengthening activities according to the physical activity guidelines.Main outcome measuresAll cause mortality and cause specific mortality (cardiovascular disease, cancer, chronic lower respiratory tract diseases, accidents and injuries, Alzheimer’s disease, diabetes mellitus, influenza and pneumonia, and nephritis, nephrotic syndrome, or nephrosis) obtained from the National Death Index records.ResultsDuring a median follow-up of 8.75 years, 59 819 adults died from all causes, 13 509 from cardiovascular disease, 14 375 from cancer, 3188 from chronic lower respiratory tract diseases, 2477 from accidents and injuries, 1470 from Alzheimer’s disease, 1803 from diabetes mellitus, 1135 from influenza and pneumonia, and 1129 from nephritis, nephrotic syndrome, or nephrosis. Compared with those who did not meet the physical activity guidelines (n=268 193), those who engaged in recommended muscle strengthening activity (n=21 428; hazard ratio 0.89, 95% confidence interval 0.85 to 0.94) or aerobic activity (n=113 851; 0.71, 0.69 to 0.72) were found to be at reduced risk of all cause mortality; and even larger survival benefits were found in those engaged in both activities (n=76 384; 0.60, 0.57 to 0.62). In addition, similar patterns were reported for cause specific mortality from cardiovascular disease, cancer, and chronic lower respiratory tract diseases.ConclusionsAdults who engage in leisure time aerobic and muscle strengthening activities at levels recommended by the 2018 physical activity guidelines for Americans show greatly reduced risk of all cause and cause specific mortality. These data suggest that the physical activity levels recommended in the guidelines are associated with important survival benefits.
Food insecurity as a risk factor for preterm birth: a prospective facility-based cohort study in rural Haiti
Authors: Richterman Aaron , Raymonville Maxi , Hossain Azfar , Millien Christophe , Joseph Jean Paul , Jerome Gregory , Franke Molly F , Ivers Louise C 
Published: July 2020

IntroductionHaiti has an estimated neonatal mortality rate of 32/1000 live births, the highest in the Western Hemisphere. Preterm birth and being born small for gestational age (SGA) are major causes of adverse neonatal outcomes worldwide. To reduce preterm birth and infants born SGA, it is important to understand which women are most at risk and how risk varies within countries. There are few studies estimating the prevalence and risk factors for these conditions in Haiti, particularly in rural regions.MethodsWe conducted a prospective cohort study of pregnant women at a rural tertiary care centre in Haiti from May to December 2017. We collected data during interviews and from the medical record. We built multivariable models to identify risk factors for preterm birth and being born SGA among women who had a facility-based delivery.Results1089 pregnant women delivered at the hospital and were included in this analysis. Median gestational age at delivery was 38 weeks (IQR 36–40). In multivariable analyses, risk factors for preterm birth included maternal age <20 years (adjusted OR (AOR) 1.76, 95% CI 1.14 to 2.72) and >34 years (AOR 1.46, 95% CI 1.01 to 2.11) and severe hunger in the household (AOR 1.57, 95% CI 1.09 to 2.26). Risk factors for SGA were age >34 years (AOR 1.76, 95% CI 1.18 to 2.59), twin pregnancy (AOR 3.28, 95% CI 1.20 to 8.95) and first pregnancy (AOR 1.57, 95% CI 1.12 to 2.23). Number of prior abortions was associated with reduced risk for SGA (AOR 0.41, 95% CI 0.17 to 0.97).ConclusionsFood insecurity as a risk factor for preterm birth stands out as an important addition to the understanding of the risk of neonatal morbidity and mortality. This association highlights a potentially important intervention target to improve birth outcomes and suggests that food support has an important role to play for pregnant women who are food insecure in low-income settings.
Protocol for a multinational risk-stratified randomised controlled trial in paediatric Crohn’s disease: methotrexate versus azathioprine or adalimumab for maintaining remission in patients at low or high risk for aggressive disease course
Authors: Harris Rachel E , Aloi Marina , de Ridder Lissy , Croft Nicholas M , Koletzko Sibylle , Levine Arie , Turner Dan , Veereman Gigi , Neyt Mattias , Bigot Laetitia , Ruemmele Frank M , Russell Richard K 
Published: July 2020

IntroductionImmunomodulators such as thiopurines (azathioprine (AZA)/6-mercaptopurine (6MP)), methotrexate (MTX) and biologics such as adalimumab (ADA) are well established for maintenance of remission within paediatric Crohn’s disease (CD). It remains unclear, however, which maintenance medication should be used first line in specific patient groups.AimsTo compare the efficacy of maintenance therapies in newly diagnosed CD based on stratification into high and low-risk groups for severe CD evolution; MTX versus AZA/6MP in low-risk and MTX versus ADA in high-risk patients. Primary end point: sustained remission at 12 months (weighted paediatric CD activity index ≤12.5 and C reactive protein ≤1.5 fold upper limit) without relapse or ongoing requirement for exclusive enteral nutrition (EEN)/steroids 12 weeks after treatment initiation.Methods and analysisREDUCE-RISK in CD is an international multicentre open-label prospective randomised controlled trial funded by EU within the Horizon2020 framework (grant number 668023). Eligible patients (aged 6–17 years, new-onset disease receiving steroids or EEN for induction of remission for luminal ± perianal CD are stratified into low and high-risk groups based on phenotype and response to induction therapy. Participants are randomised to one of two treatment arms within their risk group: low-risk patients to weekly subcutaneous MTX or daily oral AZA/6MP, and high-risk patients to weekly subcutaneous MTX or fortnightly ADA. Patients are followed up for 12 months at prespecified intervals. Electronic case report forms are completed prospectively. The study aims to recruit 312 participants (176 low risk; 136 high risk).Ethics and disseminationClinicalTrials.gov Identifier: (NCT02852694), authorisation and approval from local ethics committees have been obtained prior to recruitment. Individual informed consent will be obtained prior to participation in the study. Results will be published in a peer-reviewed journal with open access.Trial registration numberNCT02852694; Pre-results.
Dietary and Circulating Fatty Acids and Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition
Authors: Yammine Sahar , Huybrechts Inge , Biessy Carine , Dossus Laure , Aglago Elom K. , Naudin Sabine , Ferrari Pietro , Weiderpass Elisabete , Tjønneland Anne , Hansen Louise , Overvad Kim , Mancini Francesca R. , Boutron-Ruault Marie-Christine , Kvaskoff Marina , Fortner Renée T. , Kaaks Rudolf , Schulze Matthias B. , Boeing Heiner , Trichopoulou Antonia , Karakatsani Anna , La Vecchia Carlo , Benetou Vassiliki , Masala Giovanna , Krogh Vittorio , Mattiello Amalia , Macciotta Alessandra , Gram Inger T. , Skeie Guri , Quirós Jose R. , Agudo Antonio , Sánchez Maria-José , Chirlaque Maria-Dolores , Ardanaz Eva , Gil Leire , Sartor Hanna , Drake Isabel , Idahl Annika , Lundin Eva , Aune Dagfinn , Ward Heather , Merritt Melissa A. , Allen Naomi E. , Gunter Marc J. , Chajès Véronique 
Published: July 2020

AbstractBackground:Fatty acids impact obesity, estrogens, and inflammation, which are risk factors for ovarian cancer. Few epidemiologic studies have investigated the association of fatty acids with ovarian cancer.Methods:Within the European Prospective Investigation into Cancer and Nutrition (EPIC), 1,486 incident ovarian cancer cases were identified. Cox proportional hazard models with adjustment for ovarian cancer risk factors were used to estimate HRs of ovarian cancer across quintiles of intake of fatty acids. False discovery rate was computed to control for multiple testing. Multivariable conditional logistic regression models were used to estimate ORs of ovarian cancer across tertiles of plasma fatty acids among 633 cases and two matched controls in a nested case–control analysis.Results:A positive association was found between ovarian cancer and intake of industrial trans elaidic acid [HR comparing fifth with first quintileQ5-Q1 = 1.29; 95% confidence interval (CI) = 1.03–1.62; Ptrend = 0.02, q-value = 0.06]. Dietary intakes of n-6 linoleic acid (HRQ5-Q1 = 1.10; 95% CI = 1.01–1.21; Ptrend = 0.03) and n-3 α-linolenic acid (HRQ5-Q1 = 1.18; 95% CI = 1.05–1.34; Ptrend = 0.007) from deep-frying fats were also positively associated with ovarian cancer. Suggestive associations were reported for circulating elaidic (OR comparing third with first tertileT3-T1 = 1.39; 95% CI = 0.99–1.94; Ptrend = 0.06) and α-linolenic acids (ORT3-T1 = 1.30; 95% CI = 0.98–1.72; Ptrend = 0.06).Conclusions:Our results suggest that higher intakes and circulating levels of industrial trans elaidic acid, and higher intakes of linoleic acid and α-linolenic acid from deep-frying fat, may be associated with greater risk of ovarian cancer.Impact:If causal, eliminating industrial trans-fatty acids could offer a straightforward public health action for reducing ovarian cancer risk.
Early Relapse Risk in Patients with Newly Diagnosed Multiple Myeloma Characterized by Next-generation Sequencing
Authors: D'Agostino Mattia , Zaccaria Gian Maria , Ziccheddu Bachisio , Rustad Even H. , Genuardi Elisa , Capra Andrea , Oliva Stefania , Auclair Daniel , Yesil Jennifer , Colucci Paola , Keats Jonathan J. , Gambella Manuela , Bringhen Sara , Larocca Alessandra , Boccadoro Mario , Bolli Niccolò , Maura Francesco , Gay Francesca 
Published: July 2020

Abstract

Purpose:
Duration of first remission is important for the survival of patients with multiple myeloma.

Experimental Design:
From the CoMMpass study (NCT01454297), 926 patients with newly diagnosed multiple myeloma, characterized by next-generation sequencing, were analyzed to evaluate those who experienced early progressive disease (PD; time to progression, TTP ≤18 months).

Results:
After a median follow-up of 39 months, early PD was detected in 191/926 (20.6%) patients, 228/926 (24.6%) patients had late PD (TTP &gt;18 months), while 507/926 (54.8%) did not have PD at the current follow-up. Compared with patients with late PD, patients with early PD had a lower at least very good partial response rate (47% vs. 82%, P &lt; 0.001) and more frequently acquired double refractoriness to immunomodulatory drugs (IMiD) and proteasome inhibitors (PI; 21% vs. 8%, P &lt; 0.001). Patients with early PD were at higher risk of death compared with patients with late PD and no PD (HR, 3.65; 95% CI, 2.7–4.93; P &lt; 0.001), showing a dismal median overall survival (32.8 months). In a multivariate logistic regression model, independent factors increasing the early PD risk were TP53 mutation (OR, 3.78, P &lt; 0.001), high lactate dehydrogenase levels (OR, 3.15, P = 0.006), λ-chain translocation (OR, 2.25, P = 0.033), and IGLL5 mutation (OR, 2.15, P = 0.007). Carfilzomib-based induction (OR, 0.15, P = 0.014), autologous stem-cell transplantation (OR, 0.27, P &lt; 0.001), and continuous therapy with PIs and IMiDs (OR, 0.34, P = 0.024) mitigated the risk of early PD.

Conclusions:
Early PD identifies a high-risk multiple myeloma population. Further research is needed to better identify baseline features predicting early PD and the optimal treatment approaches for patients at risk.
Toward a New Molecular Taxonomy of Diffuse Large B-cell Lymphoma
Authors: Ennishi Daisuke , Hsi Eric D. , Steidl Christian , Scott David W. 
Published: July 2020

Abstract
Diffuse large B-cell lymphoma (DLBCL) represents a grouping of clinically and biologically heterogeneous tumors. Application of advanced molecular technology has significantly expanded our knowledge of DLBCL pathobiology, allowing identification of subgroups with common, potentially targetable, biological themes. Here, we review the recent molecular analyses that could provide a paradigm shift to a new taxonomy, foundational to the rational transition to precision medicine. We discuss how classification systems may be synthesized into a common taxonomy, drawing strength from the relationships between genetic alterations, gene expression, and tumor microenvironment. Finally, challenges to translating such a taxonomy to the clinic will be outlined.
Regression of Atherosclerosis in ApoE−/− Mice Via Modulation of Monocyte Recruitment and Phenotype, Induced by Weekly Dosing of a Novel “Cytotopic” Anti‐Thrombin Without Prolonged Anticoagulation
Authors: Chen Daxin , Li Ke , Festenstein Sam , Karegli Julieta , Wilkinson Hannah , Leonard Hugh , Wei Lin‐Lin , Ma Ning , Xia Min , Tam Henry , Wang Jian‐an , Xu Qingbo , McVey John H. , Smith Richard A. G. , Dorling Anthony 
Published: July 2020

Background

Anticoagulants induce atherosclerosis regression in animal models but exploiting this clinically is limited by bleeding events. Here we test a novel thrombin inhibitor,
PTL
060, comprising hirulog covalently linked to a synthetic myristoyl electrostatic switch to tether to cell membranes.

Methods and Results

ApoE−/− mice were fed chow or high‐fat diets, before transplantation of congenic aortic segments or injection of
PTL
060, parental hirulog, control saline, or labeled
CD
11b positive cells. Aortic transplants from transgenic mice expressing anticoagulants on endothelium did not develop atherosclerosis. A single intravenous injection of
PTL
060, but not hirulog inhibited atheroma development by >50% compared with controls when assessed 4 weeks later. Mice had prolonged bleeding times for only one seventh of the time that
PTL
060 was biologically active. Repeated weekly injections of
PTL
060 but not hirulog caused regression of atheroma. We dissected 2 contributory mechanisms. First, the majority of CCR2+ (C‐C chemokine receptor type 2+) monocytes recruited into plaques expressed CCR7 (C‐C chemokine receptor type 7), ABCA1 (ATP‐binding cassette transporter – 1), and interleukin‐10 in
PTL
060 mice, a phenotype seen in <20% of CCR2+ recruits in controls. Second, after several doses, there was a significant reduction in monocyte recruits, the majority of which were CCR2‐negative with a similar regression‐associated phenotype. Regression equivalent to that induced by intravenous
PTL
060 was induced by adoptive transfer of
CD
11b+ cells pre‐coated with
PTL
060.

Conclusions

Covalent linkage of a myristoyl electrostatic switch onto hirulog in
PTL
060 uncouples the pharmacodynamic effects on hemostasis and atherosclerosis, such that plaque regression, mediated predominantly via effects on monocytes, is accompanied by only transient anticoagulation.