bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal Weight Gain and Infant Birth Weight in Women with Class III Obesity
Authors: Tucker Ann R. , Brown Haywood L. , Dotters-Katz Sarah K. 
Published: January 2020

Abstract
Objective The aim of this study is to describe the impact of maternal weight gain on infant birth weight among women with Class III obesity.
Study Design Retrospective cohort of women with body mass index (BMI) ≥40 kg/m2 at initial prenatal visit, delivered from July 2013 to December 2017. Women presenting 14/0 weeks of gestational age (GA), delivering preterm, or had multiples or major fetal anomalies excluded. Maternal demographics and complications, intrapartum events, and neonatal outcomes abstracted. Primary outcomes were delivery of large for gestational age or small for gestational age (SGA) infant. Bivariate statistics used to compare women gaining less than Institute of Medicine (IOM) recommendations (LTR) and women gaining within recommendations (11–20 pounds/5–9.1 kg) (at recommended [AR]). Regression models used to estimate odds of primary outcomes.
Results Of included women (n = 230), 129 (56%) gained LTR and 101 (44%) gained AR. In sum, 71 (31%) infants were LGA and 2 (0.8%) were SGA. Women gaining LTR had higher median entry BMI (46 vs. 43, p < 0.01); other demographics did not differ. LTR women were equally likely to deliver an LGA infant (29 vs. 34%, p = 0.5) but not more likely to deliver an SGA infant (0.8 vs. 1%, p > 0.99). After controlling for confounders, the AOR of an LGA baby for LTR women was 0.79 (95% CI: 0.4–1.4).
Conclusion In this cohort of morbidly obese women, gaining less than IOM recommendations did not impact risk of having an LGA infant, without increasing risk of an SGA infant.
cd2sbgnml: bidirectional conversion between CellDesigner and SBGN formats
Authors: Balaur Irina , Roy Ludovic , Mazein Alexander , Karaca S Gökberk , Dogrusoz Ugur , Barillot Emmanuel , Zinovyev Andrei 
Published: January 2020

Abstract

Motivation
CellDesigner is a well-established biological map editor used in many large-scale scientific efforts. However, the interoperability between the Systems Biology Graphical Notation (SBGN) Markup Language (SBGN-ML) and the CellDesigner’s proprietary Systems Biology Markup Language (SBML) extension formats remains a challenge due to the proprietary extensions used in CellDesigner files.

Results
We introduce a library named cd2sbgnml and an associated web service for bidirectional conversion between CellDesigner’s proprietary SBML extension and SBGN-ML formats. We discuss the functionality of the cd2sbgnml converter, which was successfully used for the translation of comprehensive large-scale diagrams such as the RECON Human Metabolic network and the complete Atlas of Cancer Signalling Network, from the CellDesigner file format into SBGN-ML.

Availability and implementation
The cd2sbgnml conversion library and the web service were developed in Java, and distributed under the GNU Lesser General Public License v3.0. The sources along with a set of examples are available on GitHub (https://github.com/sbgn/cd2sbgnml and https://github.com/sbgn/cd2sbgnml-webservice, respectively).

Supplementary information
Supplementary data are available at Bioinformatics online.
Smoking as a Risk Factor of Invasive Fungal Disease: Systematic Review and Meta-Analysis
Authors: Pourbaix Annabelle , Lafont Rapnouil Baptiste , Guéry Romain , Lanternier Fanny , Lortholary Olivier , Cohen Jérémie F 
Published: January 2020

Abstract
To investigate the association between smoking and invasive fungal disease (IFD), we searched MEDLINE and Web of Science for studies published until September 2018. Two authors independently performed study selection and data extraction. Relative risks (RRs) were pooled using random-effects meta-analysis. We included 25 studies (18 171 participants; 2527 IFD cases). The meta-analysis showed an increased risk of IFD in smokers (RR 1.41 [95% confidence interval 1.09–1.81]; P = .008). The risk of IFD was higher in retrospective than in prospective studies (RR 1.93 [1.28–2.92] vs. 1.02 [0.78–1.34]; P = .04), in studies with multivariate adjustment compared to studies with univariate analysis (RR 2.15 [1.27–3.64] vs. 1.15 [0.88–1.51]; P = .06), and in studies published after 2002 (RR 2.08 [1.37–3.15] vs. 0.95 [0.75–1.22]; P = .008); other subgroup characteristics did not significantly influence the association in metaregression. Smoking cessation strategies should be implemented, especially in patients who are already at risk for IFD.
A rare cause of acute ST-elevation myocardial infarction: case report of native aortic valve thrombosis
Authors: Beekman-van Solkema Gerrie , Schoots M H , Pundziute-Do Prado G 
Published: January 2020

Abstract

Background
One to 13% of all patients with the clinical diagnosis of an acute coronary syndrome (ACS) show no evidence of significant obstructive coronary artery disease on angiography. Less common causes should be considered in those situations. A very rare cause of ACS is native aortic valve thrombosis.

Case summary
A 69-year-old previously healthy woman presented with acute chest pain. The electrocardiogram showed an anterolateral ST-elevation myocardial infarction (STEMI). She was immediately transferred for primary percutaneous coronary intervention. Shortly after arriving in hospital her condition deteriorated, with development of cardiogenic shock necessitating cardiopulmonary resuscitation. A coronary angiogram was performed during resuscitation that did not reveal any obstructive coronary artery disease. Echocardiography showed no pericardial effusion, no significant left-sided valve pathology, no signs of an aortic dissection or pulmonary embolism. She died of cardiogenic shock of unknown cause. Permission for autopsy was obtained. Pathologic examination revealed a large anterolateral myocardial infarction caused by a mass attached to the bottom of the left coronary cusp of the native aortic valve, which was large enough to occlude the ostium of the left main coronary artery. Microscopic analysis showed a thrombus of unknown origin. The aortic valve itself showed no signs of pathology.

Discussion
An ST-elevation myocardial infarction due to native aortic valve thrombosis is a rare condition, especially when there are no significant valvular abnormalities. This case demonstrates that thrombosis can develop in an apparently healthy middle-aged woman without any history of thrombotic disease.
It Is What You Have, Not What You Lose: Effects of Perceived Gains and Losses on Goal Orientation Across Adulthood
Authors: Gong Xianmin , Freund Alexandra M 
Published: January 2020

AbstractObjectivesGoal orientation tends to shift from predominantly striving for gains to maintenance and loss avoidance across adulthood. A dominant hypothesis states that age-related increases in losses drive the motivational shift. The present study tests this hypothesis and an alternative, namely that perceived accumulation of resources/assets and discrepancy between the actual and desired state underlie the stronger maintenance and loss-avoidance orientation in older than younger adults.MethodsData from N = 182 U.S. adult participants on Amazon Mechanical Turk (preregistered; 50.0% female; 19–77 years, M = 45.1, SD = 15.86) comprise measures of demographics, goal orientation in 16 selected life domains as well as perceived accumulation, losses, actual-desired discrepancy in the same domains.ResultsMultilevel modeling analyses showed that, as expected and confirming prior research, gain orientation decreased and maintenance orientation increased with age. Moreover, both perceived losses and accumulation of resources/assets increased with age, while the actual-desired discrepancy decreased. Larger perceived accumulation and smaller actual-desired discrepancies were associated with stronger maintenance orientation. Regardless of age, a smaller actual-desired discrepancy was also associated with stronger loss-avoidance orientation. Contrary to predictions, perceived losses were negatively associated with gain orientation, but not significantly associated with maintenance or loss-avoidance orientation.DiscussionResults replicate the shift in goal orientation across adulthood. Speaking against the loss hypothesis, perceived accumulation of resources/assets and actual-desired discrepancy seem to play an important role in determining goal orientation over adulthood, while the role of perceived losses may be less significant than commonly assumed.
Example of Compact Special Lagrangians with a Stable Singularity
Authors: Imagi Yohsuke 
Published: January 2020

AbstractWe construct a family of compact almost Calabi–Yau manifolds of complex dimension 3 and therein a corresponding family of compact special Lagrangians with one-point singularities modelled upon that $T^2$-cone constructed by Harvey and Lawson [7, Chapter III.3.A, Theorem 3.1] and characterised by Haskins [8, Theorem A] as a stable $T^2$-cone in the terminology by Joyce [16, Definition 3.4 and Example 3.5].
Secessionist Strategy and Tactical Variation in the Pursuit of Independence
Authors: Griffiths Ryan D 
Published: January 2020

AbstractHow do secessionist movements formulate strategy and choose tactics? Secessionism takes place on a strategic playing field that shapes tactical behavior, driving some movements to choose armed rebellion while others prefer nonviolent civil resistance or electoral competition. Secessionist movements attempt to compel and make normative appeals in different combinations depending on local conditions such as regime type, the strength of the state, and the degree to which the region is already de facto independent. These efforts are aimed at not only the home state, but also the international community that can apply pressure on the home state to negotiate with the secessionists. I identify six kinds of movements—democratized, indigenous legal, combative/strong state, combative/weak state, decolonial, and de facto—and I outline the perils and possibilities inherent in each kind. I then construct a theoretical framework and test the implications using original data on secessionist tactics between 1946 and 2011.
Biogenic silver nanoparticles in the treatment of experimental pythiosis Bio-AgNP in pythiosis therapy
Authors: Valente Júlia de Souza Silveira , Brasil Carolina Litchina , Braga Caroline Quintana , Zamboni Rosimeri , Sallis Elisa Simone Viégas , Albano Ana Paula Neuschrank , Zambrano Cristina Gomes , Franz Helen Cabaldi , Pötter Luciana , Panagio Luciano Aparecido , Reis Guilherme Fonseca , Botton Sônia de Avila , Pereira Daniela Isabel Brayer 
Published: January 2020

Abstract
Pythiosis is a rapidly progressing disease that can be lethal to affected individuals due to resistance to available therapeutic protocols. The disease affects mammals, with the largest number of reports in horses and humans. The present study investigated the activity of biogenic silver nanoparticles (bioAgNP) in the treatment of experimental pythiosis. The disease was reproduced in nine female 90-day-old New Zealand rabbits. Animals were divided into three groups: group1 (control, n = 3) daily and topically treated with a nonionized gel-based formulation and 1 ml of sterile distilled water intralesion administered every 48 hours; group 2 (n = 3), daily and topically treated with gel-based formulation containing 1 μg/ml bio-AgNP; group 3 (n = 3), treated with 1 ml bio-AgNP in 1 μg/ml aqueous solution intralesion administered every 48 hours. Animals were treated for 45 days, and the area of subcutaneous lesions was measured every 5 days. Results showed that groups 2 and 3 differed from control group (P &lt; .05) in the lesion area, as well as the amount of hyphae within the lesions. It was observed that lesions of treated animals (groups 2 and 3) did not differ from each other, showing that the application route did not influence the regression of lesions. However, it was observed that one animal from group 2 reached clinical cure at 35 days of treatment. This research is pioneer in the application of nanocomposites for the treatment of experimental pythiosis and showed that bio-AgNP can be powerful allies of integrative medicine and can be included in pythiosis therapeutic protocols.
Enacting the Logic of Possibility in Organizations and Management1
Authors: Feldman Martha S , Sengupta Prami 
Published: January 2020

AbstractPublic management sits at the intersection of social science studies and management practice. Social science studies are largely based on a logic of probability. Management practice, however, requires both a logic of probability and a logic of possibility. As a way of increasing the relevance of social science research to management practice, we explore ways of developing scholarship based on a logic of possibility. We discuss three approaches that provide ways of theorizing possibility: process theorizing, pragmatism, and practice theory. We identify concepts within each approach that can be used to reorient scholarship to a logic of possibility. We review an area of study, the field of routine dynamics, where these three approaches have been formative as a way of illustrating what can be achieved through adopting a logic of possibility.
Genetic variation in intraspecific populations of Rabdophaga rosaria (Diptera: Cecidomyiidae) indicating possible diversification scenarios into sibling species along with host range expansion on willows (Salicaceae: Salix)
Authors: Sato Shinsuke , Harris Keith M , Collet Dominique M , Kim Wanggyu , Yukawa Junichi 
Published: January 2020

AbstractWe analysed the COI gene of mitochondrial DNA extracted from larvae of Rabdophaga (Diptera: Cecidomyiidae) that induce rosette galls on Salix in the Holarctic Region. Genetic data show that they belong to species groups of Rabdophaga rosaria and Rabdophaga strobiloides. A maximum likelihood tree indicates that R. rosaria and R. strobiloides populations are divided into clades 1 and 2, respectively. Clade 1 is divided into subclades 1 and 2, and the latter is further divided into subclades 2A and 2B. Subclade 1 consists of populations on several Salix species of section Cinerella in subgenus Vetrix in Georgia and the UK. Subclade 2A contains populations on Salix alba (section Salix, subgenus Salix) in The Netherlands and the UK. Subclade 2B consists of populations on section Helix in Poland, Phylicifoliae in Alaska and Salix species in the Eastern Palaearctic Region. The genetic differences between populations of subclades 1, 2A and 2B range from 1.06 to 3.46%. We propose a possible diversification scenario of R. rosaria into sibling species through the expansion of host plant ranges. Clade 2 consists of R. strobiloides populations on two Alaskan Salix species of the sections Hastatae and Sitchenses in subgenus Vetrix.
Genetic Variations of CYP19A1 Gene and Stroke Susceptibility: A Case–Control Study in the Chinese Han Population
Authors: Cai Qing , Zheng Jianwen , Bai Mei , He Xue , Wang Li , He Yongjun , Yuan Dongya , Huang Tingqin , Zhao Junjie , Wu Yuan , Ma Xudong , Zhang Ming , Jin Tianbo , Gao Guodong 
Published: January 2020

Objective:
This study aimed to explore the association between genetic variations of CYP19A1 and stroke susceptibility in the Chinese Han population.

Methods:
A total of 477 stroke patients and 480 healthy controls were recruited in this study. The genotyping of CYP19A1 polymorphisms (rs4646, rs6493487, rs1062033, rs17601876, and rs3751599) was performed by the Agena MassARRAY platform. Under logistic regression models, we evaluated the associations of CYP19A1 polymorphisms and stroke susceptibility by odds ratio and 95% confidence interval.

Results:
Our study showed that rs4646 (codominant: P = 0.020; recessive: P = 0.016) and rs17601876 (allele: P = 0.044; codominant: P = 0.011; dominant: P = 0.009; recessive: P = 0.046) significantly decreased the risk of stroke. In the stratification analysis, rs4646 is associated with decreased stroke risk among the individuals older than 64 years (codominant: P = 0.028; recessive: P = 0.010) and women (codominant: P = 0.029; recessive: P = 0.029), whereas rs1062033 increased stroke risk in the subgroup of age 64 years and younger (recessive: P = 0.042). The rs17601876 polymorphism has a strong relationship with stroke susceptibility, which is age and gender dependent. In haplotype analysis, we found a block (rs17601876 and rs3751599), and Ars17601876Grs3751599 haplotype is related to an increased stroke risk (P < 0.05). In addition, CYP19A1 variations had effects on clinical characteristics.

Conclusion:

CYP19A1 polymorphisms were significantly associated with stroke susceptibility in the Chinese Han population.
PLASMA RICH IN GROWTH FACTORS FOR PERSISTENT MACULAR HOLE: A PILOT STUDY
Authors: Arias Juan D. , Hoyos Andrea T. , Alcántara Betzy , Sanchez-Avila Ronald M. , Arango Francisco J. , Galvis Virgilio 
Published: January 2020

Purpose:
Persistent macular hole (PMH) is a challenge for retina surgeons. There are limited surgical techniques described achieving PMH closure. For more than a decade, techniques with blood derivatives have been described without optimal outcomes. The aim of this article is to report the usefulness of the plasma rich in growth factors (PRGF) as a new way to improve PMH closure.

Methods:
This is an observational study. Two patients with PMH were chosen at the FOSCAL Internacional, Floridablanca, Colombia. For each patient, a complete ophthalmological examination before and after treatment was performed. It included best-corrected visual acuity and fundus examination. Features of swept-source optical coherence tomographic angiography (Topcon) at baseline and after treatment were included. Preoperative evaluation included the following: previous vitreoretinal surgery for macular hole, macular hole measurement and classification, and dissociated optic nerve fiber layer in en-face map, confirming a prior internal limiting membrane peeling. Plasma rich in growth factors–Endoret technology is characterized by moderate platelet concentration and absence of leukocytes, which requires calcium chloride for platelet activation. It is obtained from each patient's blood sample, submitted to a series of processes to acquire a three-dimensional fibrin scaffold, rich in hundreds of proteins, which seems to have therapeutic potential. This PRGF membrane is placed into the macular hole with forceps through a pars plana vitrectomy after complete air–fluid exchange. Supernatant was placed on the macula and left it for 2 minutes. It is then aspirated, and gas or silicone oil was left as a tamponade.

Results:
Follow-up period was of 12 months for each patient. Complete macular hole closure was achieved in both cases. Best-corrected visual acuity changed from 20/200 preoperatively to 20/100 postoperatively in Patient #1 and from 20/1,500 to 20/100 in Patient #2.

Conclusion:
Plasma rich in growth factors has been primarily investigated for ocular surface diseases. This is a pilot study using this technology for PMH treatment. The use of PRGF may be an effective and safe surgical technique with satisfactory anatomical and functional results for PMH. Because of its own biomaterials and proteins, PRGF not only allows anatomical closure but also seems to stimulate tissue regeneration.
A 6-Week, Prospective, Randomized, Single-Masked Study of Lifitegrast Ophthalmic Solution 5% Versus Thermal Pulsation Procedure for Treatment of Inflammatory Meibomian Gland Dysfunction
Authors: Tauber Joseph 
Published: January 2020

Purpose:
Meibomian gland dysfunction (MGD) is present in most cases of dry eye disease. MGD involves both inflammatory and obstructive etiologies. We compared efficacy and safety of treatment to reduce inflammation (lifitegrast) versus obstruction [thermal pulsation procedure (TPP)] in patients with inflammatory MGD over 42 days.

Methods:
This was a single-center, 6-week, prospective, randomized, single-masked study of adults with inflammatory MGD, defined as having all of the following: burning, stinging, dryness; thickened secretions or occlusion of glands; eyelid redness; and elevated matrix metalloproteinase-9. Patients received lifitegrast ophthalmic solution 5% twice daily for 42 days or one TPP treatment at day 0. Seven symptoms and 8 objective measures of dry eye disease were assessed.

Results:
Overall, 40 of 50 randomized patients (80%) were women with mean (SD) age 65.8 (8.9) years. Lifitegrast-treated (n = 25) versus TPP-treated (n = 25) patients had greater improvement from baseline to day 42 in eye dryness [mean (SD) change from baseline: −1.05 (0.79), lifitegrast; −0.48 (0.96), TPP; P = 0.0340], corneal staining [−0.55 (0.80), lifitegrast; 0.12 (1.09), TPP; P = 0.0230], and eyelid redness [−0.77 (0.43), lifitegrast; −0.38 (0.58), TPP; P = 0.0115]; trend favored lifitegrast for best corrected visual acuity and gland patency. Unexpectedly, TPP treatment did not improve lipid layer thickness or gland patency compared with lifitegrast. No adverse events were reported.

Conclusions:
Although MGD is often considered a disease of gland obstruction, these findings demonstrate antiinflammatory treatment with lifitegrast significantly improved patient symptoms and signs compared with treatment for obstruction (TPP). Lifitegrast should be included in treatment for inflammatory MGD.
Longitudinal Changes in Adult Bony Orbital Volume
Authors: Chon Brian , Zhang Kevin R. , Hwang Catherine J. , Perry Julian D. 
Published: January 2020

Purpose:
To our knowledge, no prior study has measured bony orbital volume in a group of subjects over time. This study evaluates longitudinal changes in bony orbital volume with age.

Methods:
A search was created for patients with digitized CT imaging studies of the orbit at least 8 years apart. Charts with a history of prior head trauma, head and neck tumors, sinus disease, head surgery, elevated intracranial pressure, thyroid eye disease, or conditions that could affect bone metabolism were excluded. Three outcome measures were used: orbital volume, medial orbital wall length, and lateral orbital wall length. Categorical data were summarized with frequency (%); normally distributed continuous data are summarized with mean (standard deviation), and non-normally distributed data were summarized with median. Normality was verified with Shapiro–Wilk Test. Paired t-tests were used to analyze the differences in the 3 outcome variables.

Results:
One hundred and eighty-two subjects, 91 males and 91 females, were included. The median time between CT scans was 9.4 years. Orbital volume was significantly larger at the second scan than the first (p < 0.001). The average difference in orbital volume was 0.91 ml, an increase of 4.1%. Lateral orbital length was significantly shorter in the second scan than in the first (p = 0.046) though the difference was only 0.4 mm. There was no statistically significant change in medial orbital wall length.

Conclusions:
Bony orbital volume increases in individuals with age. This increase in orbital volume occurs in the context of soft tissue changes to contribute to the aging appearance of the periorbital region.