bluuebunny/crossref_metadata_2025_split huggingface dataset:
EL SEPULCRO DEL ARZOBISPO DON FRANCISCO BLANCO COMO EJEMPLO DEL “ARTE CONTAMINADO” DE MATEUS LOPES.
Authors: Vaz Ana Margarida , Goy Diz Anna 
Published: April 2020

La muerte de João de Ruão, ocurrida en Coimbra, en 1580, coincide con los últimos años del arzobispado de don Francisco Blanco de Salcedo, que rigió la sede compostelana entre 1574-81. A su fallecimiento, sus testamentarios encargaron el diseño de su sepulcro al arquitecto portugués Mateus Lopes, que hacía un par de años que se asentara en la ciudad. A través de este proyecto, este maestro introdujo en Galicia ese estilo contaminado, tan típico del quinientismo portugués y relacionado con la obra de João de Ruão, en el cual se combina arquitectura y escultura en una obra de arte total.
A este encargo le siguieron otros de mayor relevancia, pero el sepulcro del arzobispo Blanco debe ser considerado el precedente que sirvió de base al diseño y desarrollo de proyectos posteriores, por lo que su importancia y trascendencia debe ser reconsiderada.
Predicting Progression in Barrett's Esophagus: Is the Holy Grail Within Reach?
Authors: Qin Yi , Iyer Prasad G. 
Published: April 2020

Abstract
Risk stratification in Barrett's esophagus may allow aggressive management of those at “high risk” and reduction in surveillance in at “low” risk. Davison et al. report the results of the independent validation of a multibiomarker panel (TissueCypher assay) performed on biopsy tissue, in a case control study. “High-risk” patients progressed 5 times more than those at “low risk.” Sensitivity and specificity for “high-risk” patients were 29% and 86% with a positive predictive value of 23%. A negative predictive value of a “low-risk” score was 96%. These findings may allow more intensive surveillance in those at “high risk.” Despite some limitations, this assay is a potentially major advance in the management of Barrett's esophagus patients without dysplasia.
Julio De Zan contra el realismo moral. Una reconstrucción conceptual de sus proximidades con Christine Korsgaard y Ronald Dworkin
Authors: Lariguet Guillermo 
Published: April 2020

En el presente trabajo de homenaje al Profesor Julio De Zan, me concentro en su crítica al realismo moral. En su libro, La ética, los derechos y la justicia, Julio De Zan niega que existan en el ámbito moral propiedades naturales o metafísicas. Para comprender su crítica, propongo una reconstrucción conceptual de los presupuestos filosóficos que existen para su rechazo del realismo moral. Con este propósito, mi propuesta de reconstrucción conceptual consiste en complementar la ética del discurso defendida por Julio De Zan, relacionando su propuesta con dos complementos filosóficos: por un lado, con el rechazo hacia el realismo moral realizado por Ronald Dworkin en su libro Justicia para erizos; por otro lado, con el rechazo hacia el realismo moral dirigido por Christine Korsgaard en su libro Las Fuentes de la Normatividad. Aunque los tres filósofos mantienen diferencias relevantes, mantienen también un rechazo al realismo moral basado en ciertos parecidos de familia.
The crystal structure of 3-((1R,2S)-1-methylpyrrolidin-1-ium-2-yl)pyridin-1-ium tetrachloridozincate(II) monohydrate, C10H18Cl4ZnN2O
Authors: Reiss Guido J. , Sergeeva Alena 
Published: April 2020

Abstract
C10H18Cl4ZnN2O, orthorhombic, P212121 (no. 19), a = 7.0752(1) Å, b = 7.5085(1) Å, c = 29.3383(5) Å, V = 1558.57(4) Å3, Z = 4, R
gt(F) = 0.0330, wR
ref(F
2) = 0.0672, T = 290(2) K.
The crystal structure of 2-(2,3-dimethoxyphenyl)-3-hydroxy-4H-chromen-4-one, C17H14O5
Authors: Koh Dongsoo 
Published: April 2020

Abstract
C17H14O5, monoclinic, P21/c (no. 14), a = 11.7580(7) Å, b = 8.3745(5) Å, c = 13.8754(8) Å, β = 92.622(2)°, V = 1364.84(14) Å3, Z = 4, R
gt(F) = 0.0423, wR
ref(F
2) = 0.1163, T = 223(2) K.
Intrinsic Plasticity of Cerebellar Purkinje Cells Contributes to Motor Memory Consolidation
Authors: Jang Dong Cheol , Shim Hyun Geun , Kim Sang Jeong 
Published: April 2020

Intrinsic plasticity of cerebellar Purkinje cells (PCs) has recently been demonstrated in cerebellar local circuits; however, its physiological impact on cerebellar learning and memory remains elusive. Here, we suggest that intrinsic plasticity of PCs is tightly involved in motor memory consolidation based on findings from PC-specific STIM1 knockout male mice, which show severe memory consolidation deficiency in vestibulo-ocular reflex memory. Gain-up training of the vestibulo-ocular reflex produced a decrease in the synaptic weight of PCs in both the WT and KO groups. However, intrinsic plasticity was impaired only in the knockout mice. Furthermore, the observed defects in the intrinsic plasticity of PCs led to the formation of aberrant neural plasticity in the vestibular nucleus neurons. Our results suggest that synergistic modulation of intrinsic and synaptic plasticity in PCs is required for the changes in downstream plasticity in the vestibular nucleus, and thereby contributing to the long-term storage of motor memory.SIGNIFICANCE STATEMENTSynaptic plasticity is a well-known mechanism for learning and memory. Although plasticity of excitability, intrinsic plasticity, of the cerebellar Purkinje cell has been reported in both directions (potentiation and depression), the physiological role of intrinsic plasticity still remains ambiguous. In this study, we suggest that both synaptic and intrinsic plasticity are required for successful memory consolidation in cerebellar eye movement learning. Despite successful induction and maintenance of synaptic plasticity, we found deficits of memory consolidation when there were defects in intrinsic plasticity. Our results suggest that intrinsic plasticity of cerebellar Purkinje cell has a significant role in motor memory consolidation.
Budaya Media Sosial, Edukasi Masyarakat, dan Pandemi COVID-19
Authors: Sampurno Muchammad Bayu Tejo , Kusumandyoko Tri Cahyo , Islam Muh Ariffudin 
Published: April 2020

AbstractThis study wants to explore the public education of COVID-19 through the social and cultural media in it. Furthermore, this research also identifies how the media affect the community and by involving mass media communication in strategies to raise awareness about COVID-19 prevention and prevention efforts. This study uses a qualitative method by utilizing a virtual ethnographic approach that refers to the ethnographic research approach conducted in online settings about the internet and social media. The results show that (1) social media culture in Indonesia can act as a teacher who can educate the public and stimulate in the latest research related to COVID-19; (2) as education for public health services; (3) directing people to their websites and landing pages for information on the latest and most trusted COVID-19; (4) marketing innovative services such as health care social funding services; (5) posts related to case information, photos, and results (with permission) relating to COVID-19 to educate the public; (6) sharing reviews and testimonies of patients who recover as motivation and initial prevention efforts; and (7) providing support among Indonesian citizens in the face of the COVID-19 pandemic.Keywords: Social Media Culture, Public Education, Covid-19 Pandemic AbstrakPenelitian ini ingin mengeksplorasi tentang edukasi masyarakat terhadap COVID-19 melalui media sosial dan budaya yang ada di dalamnya. Lebih lanjut, penelitian ini turut mengidentifikasi bagaimana media mempengaruhi masyarakat dan dengan melibatkan komunikasi media massa dalam strategi untuk meningkatkan kesadaran tentang usaha penanganan dan pencegahan COVID-19. Penelitian ini menggunakan metode kualitatif dengan memanfaatkan pendekatan virtual etnografi yang mengacu pada pendekatan penelitian etnografi yang dilakukan dalam pengaturan online tentang internet dan media sosial. Hasil penelitian menunjukkan bahwa (1) budaya media sosial di Indonesia dapat bertindak sebagai guru yang mampu mengedukasi masyarakat dan menstimulasi dalam penelitian terbaru terkait COVID-19; (2) sebagai pendidikan layanan kesehatan masyarakat; (3) mengarahkan masyarakat ke situs web dan halaman arahan mereka untuk informasi terkait COVID-19 terbaru dan terpercaya; (4) memasarkan layanan inovatif seperti layanan dana sosial perawatan kesehatan; (5) posting terkait informasi kasus, foto, dan hasil (dengan izin) yang berkaitan dengan COVID-19 untuk mengedukasi masyarakat; (6) berbagi ulasan dan testimoni pasien yang sembuh sebagai motivasi dan upaya awal pencegahan; dan (7) memberikan dukungan antar warga negara Indonesia dalam menghadapi pandemi COVID-19.Kata kunci: Budaya Media Sosial, Edukasi Masyarakat, Pandemi Covid-19
Optimalisasi Upaya Pemerintah Dalam Mengatasi Pandemi Covid 19 Sebagai Bentuk Pemenuhan Hak Warga Negara
Authors: Bima Jati Bima Jati , Putra Gilang Rizki Aji 
Published: April 2020

Abstract:Covid-19 or corona virus is a pandemic that is being felt by almost all countries in the world. The impact is not only on the safety aspects of people's lives, but can also be felt on the political economy aspects, especially in third world countries like Indonesia. Not a few efforts made by the central government to date, but have not provided the effectiveness as it should. So it has the potential to erode public trust (public trust) on government performance. The purpose of this paper is to describe the alternatives that the government needs to try to maintain the stability of national and state life. Thus the writer uses Polivocalistic research through a case approach, comparative, historical and critical approach. Therefore, the authors come up with alternatives such as; growing collective awareness, creating state economic stability, developing science and technology and perfecting Indonesia's independence.Keywords: Humanity, Third World Country, Citizens' Rights. Abstrak:Covid-19 atau virus corona merupakan pandemi yang sedang dirasakan dampaknya oleh hampir seluruh Negara yang ada di Dunia. Dampak tersebut tidak hanya pada aspek keselamatan hidup masyarakat, melainkan dapat dirasakan pada aspek ekonomi politik terutama pada negara dunia ke tiga seperti Indonesia. Tidak sedikit upaya yang dilakukan oleh pemerintah pusat sampai hari ini namun belum memberikan efektivitas sebagaimana mestinya. Sehingga sangat berpotensi merugikan kepercayaan masyarakat (Trust Public) terhadap kinerja pemerintah. Tujuan dari penulisan ini adalah untuk memaparkan alternatif-alternatif yang perlu pemerintah coba lakukan untuk menjaga stabilitas kehidupan berbangsa dan bernegara. Dengan demikian penulis memakai metode penelitian kualitatif dengan pendekatan kepustakaan, historis, dan kritis. Oleh karena itu penulis menggagas alternatif-alternatif seperti : menumbuhkan kesatuan kolektif menciptakan stabilitas ekonomi negara mengembangkan ilmu pengetahuan dan teknologi serta menyempurnakan kemerdekaan Indonesia.Kata kunci : Kemanusian, Negara Dunia Ketiga, Hak Warga Negara.
Face validity evaluation of screening tools for gaming disorder: Scope, language, and overpathologizing issues
Authors: King Daniel L. , Billieux Joel , Carragher Natacha , Delfabbro Paul H. 
Published: April 2020

Abstract

Aim
Critics of gaming disorder (GD; i.e., Internet gaming disorder in the DSM-5; Gaming disorder in the ICD-11) have expressed concerns about the potential risks of misclassification (e.g., false positives). An important consideration of relevance to this discussion is the extent to which commonly used screening instruments contain appropriate, sensible, and relevant items. The aim of this review was to evaluate the face validity of items within current tools for GD.

Methods
A systematic review of databases identified 29 instruments. An item bank (n = 417 items) was independently evaluated by three professional raters (i.e., a senior academic in clinical psychology, a senior psychometrician, and an academic/clinical psychologist) according to guidelines for defining and measuring addiction and gaming disorder.

Findings
Evaluation of the item bank identified issues related to: scope (i.e., “scope creep” or items of questionable relevance); language (i.e., confusing language, unusual wording or syntax); and overpathologizing (i.e., pathologizing typical and/or beneficial aspects or consequences of gaming). A total of 71 items across 23 tools had at least one face validity issue.

Conclusions
Most items (83%) demonstrated satisfactory face validity and were consistent with either the DSM-5 or ICD-11 GD classification. However, many tests contain at least one item that may pathologize normal gaming behaviors. Such items refer to basic changes in mood when gaming, a desire to play or continue playing games, and experiencing immersion when gaming. This analysis highlights the challenges of screening for problematic behaviors that are thought to arise within the context of normal recreational activities.
Response trajectories of gambling severity after cognitive behavioral therapy in young-adult pathological gamblers
Authors: Granero Roser , Valero-Solis Susana , Fernández-Aranda Fernando , Gómez-Peña Mónica , Moragas Laura , Mena-Moreno Teresa , Pino-Gutierrez Amparo del , Codina Ester , Martín-Romera Virginia , Casalé Gemma , Agüera Zaida , Baenas-Soto Isabel , Valenciano-Mendoza Eduardo , Mora-Maltas Bernat , Sánchez Isabel , Lozano-Madrid María , Menchón José M. , Murcia Susana Jiménez 
Published: April 2020

Abstract

Background and aims
The significant increase in the prevalence of gambling disorder (GD) among young adults in recent years has attracted interest in determining therapeutic efficiency in this sector of the population. The aim of this work was to estimate the response trajectories of gambling severity during the six-month follow-up after a cognitive behavioral therapy (CBT) program in young adult patients and to identify the main variables associated with each trajectory.

Methods
The sample included n = 192 patients, aged 19–35 years old, seeking treatment for GD. Response trajectories were identified through latent class growth analysis.

Results
Three trajectories emerged: T1 (n = 118, 61.5%), composed of patients with severe GD at pre-treatment and good evolution to recovery; T2 (n = 62, 32.3%), with patients with moderate-high GD affectation at baseline and good evolution to recovery; and T3 (n = 12, 6.3%), with participants with severe baseline GD severity and poor evolution after CBT (Abbott, 2019). The highest risk of poor therapeutic outcomes was related to lower social index positions, high emotional distress, high scores in harm avoidance and low scores in self-directedness.

Discussion and conclusions
Differences in the response trajectories at short-term follow-up after CBT reveal heterogeneity in the samples including young and young-adult GD patients. Patients' phenotype at baseline should be considered when developing efficient, person-centered intervention programs, which should comprise strategies aimed at increasing emotional regulation capacities, self-esteem and self-efficacy, with the aim of avoiding relapses in the medium-long term after therapy.
Inhibitory control and problematic Internet-pornography use – The important balancing role of the insula
Authors: Antons Stephanie , Matthias Brand 
Published: April 2020

Abstract

Background and aims
Diminished control over a specific behavior is a core characteristic in addictive behaviors such as problematic Internet-pornography (IP) use. First studies suggest that a hyperactivity of the impulsive system is one reason for impulsive behaviors in the context of problematic IP use. The tripartite-process theory of addiction explains neurocognitive mechanisms beyond common dual-process theories in addictive behaviors. However, the role of the reflective and interoceptive system is still unresolved.

Methods
The study comprised a stop-signal task (SST) including neutral and pornographic images during fMRI and questionnaires to investigate associations between symptoms of problematic IP use, craving, and neural activity of the impulsive, reflective, and interoceptive system. We examined 28 heterosexual males with varying symptom severity of problematic IP use.

Results
Data indicates that individuals with more symptoms of problematic IP use showed better performance in the SST which was linked to decreased insula and inferior frontal gyrus activity during pornographic image processing. An increase in craving was associated with lower activity of the ventral striatum during pornographic image processing. The interoceptive system showed varying effects. Increased insula activity during inhibitory control and decreased activity during pornographic image processing were associated with higher inhibitory control performance.

Discussion and Conclusion
Effects of tolerance and motivational aspects may explain the better inhibitory control performance in individuals with higher symptom severity which was associated with differential activity of the interoceptive and reflective system. Diminished control over IP use presumably results from the interaction between the impulsive, reflective, and interoceptive systems.
Peripherally administered KP-10 prevents development of insulin-induced hypoglycemic shock in diabetic rhesus monkeys
Authors: Qureshi IZ , Fatima I 
Published: April 2020

Aim
This study investigated whether kisspeptin-10 (KP-10) prevents diabetic rhesus monkeys from insulin-induced hypoglycemic shock.

Materials and methods
Thirty-six adult male rhesus monkeys were used, six in each group. Diabetes was induced with streptozotocin (45 mg/kg b.w.; single dose i.v.). Groups were as: saline control, insulin alone, pre-insulin (treated with KP-10, 30 min before insulin), post-insulin (treated with KP-10, 30 min after insulin), treated with premix dose of KP-10 (50 μg) and insulin, and the group treated with the kisspeptin antagonist P234 (50 μg). Following an overnight fast, each animal was subjected to respective treatment, and blood glucose concentrations were recorded every 30-min interval for 3 h.

Results
Intergroup comparisons demonstrated that treatment with KP-10 prior to insulin administration and kisspeptin–insulin premix treatment allowed blood glucose levels to rise to significantly higher levels (p < 0.001) by 180 min in diabetic and healthy animals compared to treatment with insulin alone. However, intragroup comparisons revealed a significant decrease in blood glucose level in diabetic animals only. Treatment with P234 antagonist followed by insulin administration abolished the preventive action of kisspeptin, whereby blood glucose decreased significantly (p < 0.001) in both diabetic and healthy animals. KP-10 post-insulin treatment, however, remained ineffective and led, instead, to significantly decreased glucose concentrations by 180 min in both diabetic and healthy animals when compared to animals treated with insulin alone.

Conclusions
KP-10 bears therapeutic potential to prevent hypoglycemic shock that may sometimes occur during intensive insulin therapy. Several pharmacological aspects of its interaction with insulin and other drugs, however, remain to be investigated.
Kritikus állapotú, légzéstámogatást igénylő COVID–19-fertőzött beteg ellátásának gyakorlati szempontjai
Authors: Végh Tamás , László István , Juhász Marianna , Berhés Mariann , Fábián Ákos , Koszta György , Molnár Csilla , Fülesdi Béla 
Published: April 2020

Absztrakt:
2019 decemberében egy új típusú pneumoniajárvány kitöréséről számoltak be a kínai
Wuhan városából, melynek kórokozója egy új koronavírus volt. A kezdetben
állatról emberre terjedő betegség később emberről emberre is terjedt,
világjárványt okozva. A vírus okozta betegség (COVID–19) a tünetmentestől az
enyhe tünetekkel járón keresztül a súlyos, légzési elégtelenséggel, intenzív
osztályos ellátást igénylő spektrumon keresztül változatos formában megjelenhet.
Ez utóbbi betegcsoport ellátása jelentős terhet ró az egészségügyre. Ezen
összefoglaló célja az intenzív ellátást és légzéstámogatást/gépi lélegeztetést
igénylő betegek ellátásának gyakorlati aspektusait hivatott bemutatni. Orv
Hetil. 2020; 161(17): 678–684.
Carácterización de la especie Chrysobalanus Icaco como alternativa de reforestación para mitigar procesos de erosión costera. Estudio de caso sostenibilidad ambiental de la especie en el departamento de Bolívar-Colombia
Authors: Díaz Mendoza Claudia Patricia , Ayola Mendoza Ledis Paola , Morelo González Yesid Alberto , Díaz Gómez Iván , Burgos Yunelis 
Published: April 2020

Objetivo: Estudiar la especie Chrysobalanus Icaco como alternativa de reforestación para manejo de erosión, teniendo en cuenta el potencial de la especie para la conservación y protección de suelos. Metodología: La metodología que manejó el estudio contempló métodos y técnicas inscritas en investigaciones de campo, descriptiva y correlacional. Resultados y conclusiones: El análisis indicó que la especie puede ser utilizada en el departamento para disminuir procesos erosivos. Sin embargo, las condiciones ambientales deben adecuarse con fertilizantes ricos en oligoelementos para la reforestación con Icaco con fines de aprovechamiento agroindustrial, manejo de erosión y conservación de la especie.
Perfil do câncer infantil em um estado da Amazônia Ocidental em 2018
Authors: Da Silva Beatriz Onofre Ferreira , Santos Ilná de Matos , Cozendey Mayla Pereira , Da Costa Ruth Silva lima 
Published: April 2020

OBJETIVO: Identificar o perfil do câncer infantil em um estado da Amazônia Ocidental em 2018. MATERIAIS E MÉTODO: Trata-se de um estudo transversal, exploratório e descritivo, realizado na unidade de assistência de alta complexidade de um hospital de grande porte do Acre. A população de estudo foi formada por 49 crianças de 0 a 10 anos com diagnóstico de câncer e atendidas no local de estudo no ano de 2018. RESULTADOS: Os dados apontam que a maioria das crianças (38,8%), encontrava-se na faixa etária entre 05 a 07 anos, do sexo masculino (57,0%), de cor/raça parda (34,7%), e a maior parte delas eram procedentes do município de Rio Branco (39,0%). Os tipos de cânceres mais frequentes foram leucemias (48,0%), seguido do câncer do sistema nervoso central (18,0%) e do sarcoma de partes moles (10,0%). Frente ao ano do diagnóstico prevaleceu o ano de 2018 com 19 casos e observa-se ainda que o número de ocorrências apresentou uma tendência de crescimento a partir do ano de 2015. Quanto ao desfecho dos casos, a maioria das crianças seguem em acompanhamento 40 (82,0%), sendo que 6 (12,0%) evoluíram para óbito e 1(2,0%), para cura. CONCLUSÃO: Observou-se que o câncer infantil é problema atual e crescente, predominado em crianças de 2 a 7 anos, do sexo masculino, de cor/raça parda. A leucemia e a quimioterapia representaram o tipo de câncer e o tratamento, respectivamente, mais frequentes. Recomendam-se estratégias que contemple o diagnóstico e tratamento precoce para o enfrentamento do problema.