bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of a culturally adapted cognitive behavioural therapy-based guided self-help (CACBT-GSH) intervention to reduce social anxiety and enhance self-esteem in adolescents: a randomized controlled trial from Pakistan
Authors: Amin Rizwana , Iqbal Amna , Naeem Farooq , Irfan Muhammad 
Published: May 2020

AbstractBackground:Social anxiety is common among adolescents in Pakistan and is associated with low self-esteem. Among the recommended treatments, cognitive behavioural therapy (CBT) is effective, and self-help approaches are encouraged.Aim:To determine the effectiveness of culturally adapted CBT-based guided self-help (CACBT-GSH) intervention, using a manual ‘Khushi aur Khatoon’, for treating social anxiety when added to treatment as usual (TAU) compared with TAU only.Method:A total of 76 adolescents with social anxiety aged 13–16 years from six schools in Multan, Pakistan were recruited into this randomized controlled trial. Participants were divided into intervention and control groups in a 1:1 ratio. Social anxiety, self-esteem and fear of negative evaluation were assessed through the Liebowtiz Social Anxiety Scale for children and adolescents, the Rosenberg Self-Esteem Scale and the Brief Fear of Negative Evaluation, respectively, at baseline and at the end of the study. Guided self-help using culturally adapted CBT (CACBT)-based self-help manual (eight sessions, one session per week) was provided to the intervention group. The effect of the CACBT-GSH intervention was analysed with ANCOVA.Results:There was a statistically significant difference between the intervention and the control groups in favour of intervention. Participants in the intervention group showed reduced symptoms of social anxiety (p < .001), fear of negative evaluation (p < .001) and enhanced self-esteem (p < .001).Conclusion:The study demonstrated the effectiveness of CACBT-based guided self-help intervention in treating social anxiety and addressing the symptoms associated with it.
Determination of saliva epigenetic age in infancy, and its association with parental socio-economic characteristics and pregnancy outcomes
Authors: Popovic Maja , Fiano Valentina , Isaevska Elena , Moccia Chiara , Trevisan Morena , Rusconi Franca , De Marco Laura , Polidoro Silvia , Merletti Franco , Pizzi Costanza , Richiardi Lorenzo 
Published: May 2020

AbstractEpigenetic age acceleration (AA) has been associated with adverse environmental exposures and many chronic conditions. We estimated, in the NINFEA birth cohort, infant saliva epigenetic age, and investigated whether parental socio-economic position (SEP) and pregnancy outcomes are associated with infant epigenetic AA. A total of 139 saliva samples collected at on average 10.8 (range 7–17) months were used to estimate Horvath’s DNA methylation age. Epigenetic AA was defined as the residual from a linear regression of epigenetic age on chronological age. Linear regression models were used to test the associations of parental SEP and pregnancy outcomes with saliva epigenetic AA. A moderate positive association was found between DNA methylation age and chronological age, with the median absolute difference of 6.8 months (standard deviation [SD] 3.9). The evidence of the association between the indicators of low SEP and epigenetic AA was weak; infants born to unemployed mothers or with low education had on average 1 month higher epigenetic age than infants of mothers with high education and employment (coefficient 0.78 months, 95% confidence intervals [CIs]: −0.79 to 2.34 for low/medium education; 0.96, 95% CI: −1.81 to 3.73 for unemployment). There was no evidence for association of gestational age, birthweight or caesarean section with infant epigenetic AA. Using the Horvath’s method, DNA methylation age can be fairly accurately predicted from saliva samples already in the first months of life. This study did not reveal clear associations between either pregnancy outcomes or parental socio-economic characteristics and infant saliva epigenetic AA.
Feasibility of Group Problem Management Plus (PM+) to improve mental health and functioning of adults in earthquake-affected communities in Nepal
Authors: Sangraula M. , Turner E. L. , Luitel N. P. , van ‘t Hof E. , Shrestha P. , Ghimire R. , Bryant R. , Marahatta K. , van Ommeren M. , Kohrt B. A. , Jordans M. J. D. 
Published: May 2020

AbstractAimsPsychological interventions that are brief, acceptable, effective and can be delivered by non-specialists are especially necessary in low- and middle-income countries, where mental health systems are unable to address the high level of psychosocial needs. Problem Management Plus (PM+) is a five-session intervention designed for those impaired by psychological distress while living in communities affected by adversity. Individual PM+ has demonstrated effectiveness in reducing distress in Kenya and Pakistan, and a group version of PM+ (Group PM+) was effective for conflict-affected women in Pakistan. This paper describes a feasibility and acceptability trial of locally adapted Group PM+ for women and men in an earthquake-affected region of rural Nepal.MethodsIn this feasibility cluster randomised controlled trial, participants in the experimental arm were offered five sessions of Group PM+ and participants in the control arm received enhanced usual care (EUC), which entailed brief psycho-education and providing referral options to primary care services with health workers trained in the mental health Gap Action Programme Intervention Guide (mhGAP-IG). A mixed-methods design was used to assess the feasibility and acceptability of Group PM+. Feasibility was assessed with criteria including fidelity and retention of participants. Acceptability was assessed through in-depth interviews with participants, family members, programme staff and other stakeholders. The primary clinical outcome was depression symptoms assessed using the Patient Health Questionnaire (PHQ-9) administered at baseline and 8–8.5 weeks post-baseline (i.e. after completion of Group PM+ or EUC).ResultsWe recruited 121 participants (83% women and 17% men), with equal allocation to the Group PM+ and EUC arms (1:1). Group PM+ was delivered over five 2.5–3 hour sessions by trained and supervised gender-matched local non-specialists, with an average attendance of four out of five sessions. The quantitative and qualitative results demonstrated feasibility and acceptability for non-specialists to deliver Group PM+. Though the study was not powered to assess for effectiveness, for all five key outcome measures, including the primary clinical outcome, the estimated mean improvement was larger in the Group PM+ arm than the EUC arm.ConclusionThe intervention and trial procedures were acceptable to participants, family members, and programme staff. The communities and participants found the intervention to be beneficial. Because feasibility and acceptability were established in this trial, a fully powered randomised controlled trial will be conducted for larger scale implementation to determine the effectiveness of the intervention in Nepal.
Susceptibility of Arkansas Palmer amaranth accessions to common herbicide sites of action
Authors: González-Torralva Fidel , Norsworthy Jason K. , Piveta Leonard B. , Varanasi Vijay K. , Barber Tom , Brabham Chad 
Published: May 2020

AbstractPalmer amaranth is one of the most difficult-to-control weeds in row crop systems and has evolved resistance to several herbicide sites of action (SOAs). A late-season weed-escape survey had been conducted earlier to determine the distribution of protoporphyrinogen oxidase–inhibitor resistant Palmer Amaranth in Arkansas. The objective of this study was to evaluate the susceptibility of Arkansas Palmer amaranth accessions to commonly used herbicide SOAs. The SOAs evaluated were group 2 + 9, 3, 4, 5, 10, 14, 15, and 27, and the representative herbicide from each group was imazethapyr + glyphosate (79 + 860 g ha−1), trifluralin (1,120 g ha−1), dicamba (280 and 560 g ha−1), atrazine (560 g ha−1), glufosinate (594 g ha−1), fomesafen (395 g ha−1), S-metolachlor (1,064 g ha−1), and tembotrione (92 g ha−1), respectively. Palmer amaranth mortality varied among accessions across SOAs. Averaged across accessions, the mortality rates, by treatment in order from lowest to highest, were as follows: glyphosate + imazethapyr (16%), tembotrione (51%), dicamba at 280 g ha−1 (51%), fomesafen (76%), dicamba at 560 g ha−1 (82%), atrazine (85%), trifluralin (87%), S-metolachlor (96%), and glufosinate (99.5%). This study provides evidence that Palmer amaranth accessions with low susceptibility to glyphosate + imazethapyr, fomesafen, and tembotrione are widespread throughout Arkansas. Of the remaining SOAs, most Palmer amaranth accessions were sensitive; however, within each herbicide SOA, except glufosinate, control of some accessions was less than expected and resistance is suspected.
P Wave Anisotropy Caused by Partial Eclogitization of Descending Crust Demonstrated by Modeling Effective Petrophysical Properties
Authors: Zertani Sascha , Vrijmoed Johannes C. , Tilmann Frederik , John Timm , Andersen Torgeir B. , Labrousse Loic 
Published: May 2020

AbstractSeismological studies of large‐scale processes at convergent plate boundaries typically probe lower crustal structures with wavelengths of several kilometers, whereas field‐based studies typically sample the resulting structures at a much smaller scale. To bridge this gap between scales, we derive effective petrophysical properties on the 20‐m, 100‐m, and kilometer scales based on numerical modeling with the finite element method. Geometries representative of eclogitization of crustal material are extracted from the partially eclogitized exposures on Holsnøy (Norway). We find that the P wave velocity is controlled by the properties of the lithologies rather than their geometric arrangement. P wave anisotropy, however, is dependent on the fabric orientation of the associated rocks, as fabric variations cause changes in the orientation of the initial anisotropy. As a result, different structural associations can result in effective anisotropies ranging from ~0–4% for eclogites not associated with ductile deformation to up to 8% for those formed during ductile deformation. For the kilometer‐scale structures, a scale that in principle can be resolved by seismological studies, we obtained P wave velocities between 7.7 and 8.0 km s−1. The effective P wave anisotropy on the kilometer scale is ~3–4% and thus may explain the backazimuthal dependence of seismological images of, for example, the Indian lower crust currently underthrusting beneath the Himalaya. These results imply that seismic anisotropy could be the key to visualize structures in active subduction and collision zones that are currently invisible to geophysical methods and thus can be used to unravel the underlying processes active at depth.
Multitemporal Relationships Between the Hydroclimate and Exports of Carbon, Nitrogen, and Phosphorus in a Small Agricultural Watershed
Authors: Strohmenger L. , Fovet O. , Akkal‐Corfini N. , Dupas R. , Durand P. , Faucheux M. , Gruau G. , Hamon Y. , Jaffrezic A. , Minaudo C. , Petitjean P. , Gascuel‐Odoux C. 
Published: May 2020

AbstractAgriculture affects the biogeochemical cycles of carbon, nitrogen, and phosphorus, leading to a deterioration of surface water quality. The increasing magnitude of climate change raises questions about potential additional or mitigating effects of climate change on this deterioration. One way to understand these potential effects is to cross‐analyze the dynamics of nutrient concentrations and hydroclimatic variables at multiple time scales. Here, we used a 16‐year data set, from a 5 km2 agricultural watershed in France with a temperate oceanic climate, that contains a daily record of nutrient concentrations and hydroclimatic variables from 2002–2017. We calculated Mann‐Kendall and Theil‐Sen tests, Fourier transforms, and daily hydroclimatic distributions associated with extreme stream concentrations to investigate long‐term trends, seasonal dynamics and their interannual variations, and the daily time scale, respectively. Dynamics of dissolved organic carbon (DOC) and nitrate (NO3) concentrations displayed opposite patterns at the three temporal scales, while soluble reactive phosphorus concentrations showed decoupled dynamics, related more to extreme hydrological events. Climate and past agricultural changes seem to have a synergetic effect that leads to long‐term NO3 decrease and DOC increase. Precipitation and, to a greater extent, watershed wetness controlled seasonal and event‐driven dynamics.
Spatial Variability in Bankfull Stage and Bank Elevations of Lowland Meandering Rivers: Relation to Rating Curves and Channel Planform Characteristics
Authors: Lindroth Evan M. , Rhoads Bruce L. , Castillo Cesar R. , Czuba Jonathan A. , Güneralp İnci , Edmonds Doug 
Published: May 2020

AbstractMutual adjustment between process and form shapes the morphology of alluvial river channels, including channel banks. The tops of banks define the transition between the channel and adjacent floodplain, which corresponds to the level of incipient flooding. Despite the geomorphological and hydrological importance of this transition, few, if any, studies have extensively examined spatial variability in bank elevations and its influence on bankfull stage. This study uses an objective method to explore this variability at two spatial resolutions along three alluvial lowland meandering rivers. Results show that variability in bankfull stage is inherent to all three rivers. The mean variability of bankfull stage about the average downstream gradient in this stage is 10% to 20% of mean bankfull depth. Elevations of channel banks exhibit similar variability, even after accounting for systematic variations in heights of inner and outer banks associated with river meandering. Two‐dimensional hydraulic simulations show that the elevation range of mean variability in bankfull stage overlaps considerably with the elevation range of high curvature on rating curves, confirming that variability in bankfull stage influences the shape of these curves. The simulations verify that breaks in channel banks allow flow to extend onto the floodplain at stages below the average bankfull stage. The findings provide fundamental insight into the variable nature of bankfull conditions along meandering rivers and the role of this variability in channel‐floodplain connectivity. The results also inform river‐restoration efforts that seek to re‐establish the natural configuration of channel banks.
Anthranilic acid from Ralstonia solanacearum plays dual roles in intraspecies signalling and inter-kingdom communication
Authors: Song Shihao , Yin Wenfang , Sun Xiuyun , Cui Binbin , Huang Lei , Li Peng , Yang Liang , Zhou Jianuan , Deng Yinyue 
Published: May 2020

Abstract
Quorum sensing (QS) signals are widely utilized by bacteria to regulate biological functions in response to cell population density. Previous studies have demonstrated that Ralstonia solanacearum employs two different types of QS systems. We report here that anthranilic acid controls important biological functions and the production of QS signals in R. solanacearum. It was demonstrated that the biosynthesis of anthranilic acid is mainly performed by TrpEG. The accumulation of anthranilic acid and the transcription of trpEG occur in a cell density-dependent manner in R. solanacearum. Both the anthranilic acid and TrpEG homologues are conserved in various bacterial species. Moreover, we show that Sporisorium scitamineum sexual mating and hypha formation are strongly inhibited by the addition of exogenous anthranilic acid. Our results suggest that anthranilic acid is important for the physiology of bacteria in addition to its role in inter-kingdom communication.
A novel bacterial thiosulfate oxidation pathway provides a new clue about the formation of zero-valent sulfur in deep sea
Authors: Zhang Jing , Liu Rui , Xi Shichuan , Cai Ruining , Zhang Xin , Sun Chaomin 
Published: May 2020

Abstract
Zero-valent sulfur (ZVS) has been shown to be a major sulfur intermediate in the deep-sea cold seep of the South China Sea based on our previous work, however, the microbial contribution to the formation of ZVS in cold seep has remained unclear. Here, we describe a novel thiosulfate oxidation pathway discovered in the deep-sea cold seep bacterium Erythrobacter flavus 21–3, which provides a new clue about the formation of ZVS. Electronic microscopy, energy-dispersive, and Raman spectra were used to confirm that E. flavus 21–3 effectively converts thiosulfate to ZVS. We next used a combined proteomic and genetic method to identify thiosulfate dehydrogenase (TsdA) and thiosulfohydrolase (SoxB) playing key roles in the conversion of thiosulfate to ZVS. Stoichiometric results of different sulfur intermediates further clarify the function of TsdA in converting thiosulfate to tetrathionate (−O3S–S–S–SO3−), SoxB in liberating sulfone from tetrathionate to form ZVS and sulfur dioxygenases (SdoA/SdoB) in oxidizing ZVS to sulfite under some conditions. Notably, homologs of TsdA, SoxB, and SdoA/SdoB widely exist across the bacteria including in Erythrobacter species derived from different environments. This strongly indicates that this novel thiosulfate oxidation pathway might be frequently used by microbes and plays an important role in the biogeochemical sulfur cycle in nature.
A steeply-inclined trajectory for the Chicxulub impact
Authors: Collins G. S. , Patel N. , Davison T. M. , Rae A. S. P. , Morgan J. V. , Gulick S. P. S. ,   IODP-ICDP Expedition 364 Science Party, Christeson G. L. , Chenot E. , Claeys P. , Cockell C. S. , Coolen M. J. L. , Ferrière L. , Gebhardt C. , Goto K. , Jones H. , Kring D. A. , Lofi J. , Lowery C. M. , Ocampo-Torres R. , Perez-Cruz L. , Pickersgill A. E. , Poelchau M. H. , Rasmussen C. , Rebolledo-Vieyra M. , Riller U. , Sato H. , Smit J. , Tikoo S. M. , Tomioka N. , Urrutia-Fucugauchi J. , Whalen M. T. , Wittmann A. , Xiao L. , Yamaguchi K. E. ,   Third-Party Scientists, Artemieva N. , Bralower T. J. 
Published: May 2020

AbstractThe environmental severity of large impacts on Earth is influenced by their impact trajectory. Impact direction and angle to the target plane affect the volume and depth of origin of vaporized target, as well as the trajectories of ejected material. The asteroid impact that formed the 66 Ma Chicxulub crater had a profound and catastrophic effect on Earth’s environment, but the impact trajectory is debated. Here we show that impact angle and direction can be diagnosed by asymmetries in the subsurface structure of the Chicxulub crater. Comparison of 3D numerical simulations of Chicxulub-scale impacts with geophysical observations suggests that the Chicxulub crater was formed by a steeply-inclined (45–60° to horizontal) impact from the northeast; several lines of evidence rule out a low angle (<30°) impact. A steeply-inclined impact produces a nearly symmetric distribution of ejected rock and releases more climate-changing gases per impactor mass than either a very shallow or near-vertical impact.
Confidence drives a neural confirmation bias
Authors: Rollwage Max , Loosen Alisa , Hauser Tobias U. , Moran Rani , Dolan Raymond J. , Fleming Stephen M. 
Published: May 2020

AbstractA prominent source of polarised and entrenched beliefs is confirmation bias, where evidence against one’s position is selectively disregarded. This effect is most starkly evident when opposing parties are highly confident in their decisions. Here we combine human magnetoencephalography (MEG) with behavioural and neural modelling to identify alterations in post-decisional processing that contribute to the phenomenon of confirmation bias. We show that holding high confidence in a decision leads to a striking modulation of post-decision neural processing, such that integration of confirmatory evidence is amplified while disconfirmatory evidence processing is abolished. We conclude that confidence shapes a selective neural gating for choice-consistent information, reducing the likelihood of changes of mind on the basis of new information. A central role for confidence in shaping the fidelity of evidence accumulation indicates that metacognitive interventions may help ameliorate this pervasive cognitive bias.
Structural basis for effector protein recognition by the Dot/Icm Type IVB coupling protein complex
Authors: Kim Hyunmin , Kubori Tomoko , Yamazaki Kohei , Kwak Mi-Jeong , Park Suk-Youl , Nagai Hiroki , Vogel Joseph P. , Oh Byung-Ha 
Published: May 2020

AbstractThe Legionella pneumophila Dot/Icm type IVB secretion system (T4BSS) is extremely versatile, translocating ~300 effector proteins into host cells. This specialized secretion system employs the Dot/Icm type IVB coupling protein (T4CP) complex, which includes IcmS, IcmW and LvgA, that are known to selectively assist the export of a subclass of effectors. Herein, the crystal structure of a four-subunit T4CP subcomplex bound to the effector protein VpdB reveals an interaction between LvgA and a linear motif in the C-terminus of VpdB. The same binding interface of LvgA also interacts with the C-terminal region of three additional effectors, SidH, SetA and PieA. Mutational analyses identified a FxxxLxxxK binding motif that is shared by VpdB and SidH, but not by SetA and PieA, showing that LvgA recognizes more than one type of binding motif. Together, this work provides a structural basis for how the Dot/Icm T4CP complex recognizes effectors, and highlights the multiple substrate-binding specificities of its adaptor subunit.
Global priorities for conservation of reptilian phylogenetic diversity in the face of human impacts
Authors: Gumbs Rikki , Gray Claudia L. , Böhm Monika , Hoffmann Michael , Grenyer Richard , Jetz Walter , Meiri Shai , Roll Uri , Owen Nisha R. , Rosindell James 
Published: May 2020

AbstractPhylogenetic diversity measures are increasingly used in conservation planning to represent aspects of biodiversity beyond that captured by species richness. Here we develop two new metrics that combine phylogenetic diversity and the extent of human pressure across the spatial distribution of species — one metric valuing regions and another prioritising species. We evaluate these metrics for reptiles, which have been largely neglected in previous studies, and contrast these results with equivalent calculations for all terrestrial vertebrate groups. We find that regions under high human pressure coincide with the most irreplaceable areas of reptilian diversity, and more than expected by chance. The highest priority reptile species score far above the top mammal and bird species, and reptiles include a disproportionate number of species with insufficient extinction risk data. Data Deficient species are, in terms of our species-level metric, comparable to Critically Endangered species and therefore may require urgent conservation attention.