bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recensiones
Authors: Álvarez Álvarez Leonardo , Azpitarte Sánchez Miguel , Queralt Jiménez Argelia , Giménez Gluck David , Tajadura Tejada Javier , Sobrino Guijarro Irene , Cárdenas Cordón Alicia 
Published: December 2020

Reseña de: Óscar Alzaga Villaamil. Discursos parlamentarios (y otras disertaciones) (Leonardo Álvarez Álvarez)Reseña de: Uwe Volkmann. Elementos de una teoría de la Constitución alemana (Miguel Azpitarte Sánchez)Reseña de: Javier García Roca. La transformación constitucional del Convenio Europeo de Derechos Humanos (Argelia Queralt Jiménez)Reseña de: Fernando Rey Martínez. Derecho antidiscriminatorio (David Giménez Gluck)Reseña de: Ignacio Fernández Sarasola. Reforma constitucional: pasado, presente y futuro (Javier Tajadura Tejada)Reseña de: Miguel Agudo Zamora. Reforma constitucional y Estado autonómico (Irene Sobrino Guijarro)Reseña de: Javier Matia Portilla, Ascensión Elvira Perales y Antonio Arroyo Gil (coords.). La protección de los derechos fundamentales de personas LGTB (Alicia Cárdenas Cordón)
Indicadores físicos de um latossolo amarelo distrófico sob adubação verde
Authors: Costa Romário Martins , Matos Sâmia dos Santos , Sousa Rayssa Carolinne Mouzinho de , Leite Marcos Renan Lima , Farias Maryzélia Furtado de , Furtado Mariléia Barros , Serrano Luisa Julieth Parra 
Published: December 2020

A adubação verde é uma prática que pode trazer melhorarias nas condições físicas, químicas e biológicas do solo e contribuir para mitigação do uso do fogo na agricultura migratória. Esse estudo avalia os efeitos da adubação verde utilizando três leguminosas e dois anos de cultivo em um Latossolo Amarelo distrófico através de indicadores físicos da qualidade do solo. O delineamento experimental foi em blocos casualizados em esquema de parcelas subdivididas. As parcelas foram compostas por quatro coberturas: Mucuna aterrima, Canavalia ensiformis, Vigna unguiculata e vegetação espontânea (testemunha), as subparcelas por dois anos de cultivo (2017 e 2018), com 6 repetições. Avaliou-se a produtividade de fitomassa e os indicadores de qualidade física: densidade do solo e a resistência à penetração. As espécies Mucuna aterrima e Canavalia ensiformis apresentaram as maiores produtividades de massa fresca e seca. Não houve diferenças entre as coberturas para densidade do solo. Contudo, para a resistência a penetração, o feijão caupi mostrou-se pouco eficiente comparado a Mucuna aterrima e vegetação espontânea. Após dois anos de cultivo, houve decréscimos na densidade na camada superficial (0-10 cm) e na resistência a penetração da camada subsuperficial (20-40 cm). Contudo, quando comparado a análise prévia da área de cultivo aos dois anos de cultivo, observa-se reduções apenas na resistência à penetração da camada de 0-20 cm onde houve as maiores deposições de resíduos vegetais. Portanto, dentre as leguminosas avaliadas, a mucuna-preta e o feijão-de-porco possuem melhores potenciais produtivo de fitomassa. Nas condições edafoclimáticas do estudo, as coberturas não proporcionam alterações nos atributos físicos do solo, com excessão do feijão caupi que apresentou efeitos negativos, não sendo recomendado como cobertura, quando objetiva-se a melhoria das propriedades físicas do solo. Os anos de cultivo contribuiram para uma melhora nos atribututos físicos do solo, reduzindo a densidade e a resistência à penetração.
Formación en competencias digitales: Un diagnóstico que da voz a los estudiantes de psicopedagogía
Authors: Camacho Navarro Araceli , Salinas García Rolando Javier 
Published: December 2020

La práctica docente en la Sociedad del Conocimiento requiere de competencias digitales, esto permite que los docentes se desenvuelvan en escenarios en los que se necesita el uso reflexivo de la tecnología educativa. Es por ello que las Instituciones con énfasis en la formación de especialistas en educación necesitan hacer diagnósticos de las competencias digitales de sus estudiantes tomando en cuenta los factores que impactan en su uso y así determinar las acciones para su incorporación y fortalecimiento en este periodo formativo tratando que sea contextualizada al alumno, para lograrlo se propone el uso de las narrativas digitales. Para este estudio se aplicó un cuestionario a los alumnos que estudian psicopedagogía en una Universidad Pública de México, complementando los resultados con el análisis de 10 narrativas autobiográficas con el instrumento denominado T-autoetnografía que muestra la importancia que tiene la tecnología a largo de su vida haciendo una conexión con el periodo de formación; estos resultados permiten identificar las dimensiones en tecnología educativa que más impactan para lograr su incorporación y hacer uso de ella en su futura práctica profesional dando voz al estudiante y construyendo significados sobre tecnología.
Teaching practices in the knowledge society requires digital competences, this allows teachers to develop scenarios in which the reflexive use of educative technology is needed. That´s why the Institutions with emphasis on the training of education specialists need to diagnose the digital skills of their students taking into account the factors that impact their use and thus determine the actions for their incorporation and strengthening in this training period, trying to be contextualized to the student, to achieve this, the use of digital narratives is proposed. For this study, a questionnaire was applied that was supplemented with 10 T-autoethnographies from a Mexican public university were studied, these autobiographical narratives show the importance that technology has had during their lives, making a connection with the formative period. These results allow the identification of the dimensions in educative technology that are more impacting for a student in order to achieve their incorporation and use in their future professional practice giving the student a voice and building meanings about technology.
Análisis psicométrico de una prueba para evaluar la competencia digital de estudiantes de Educación Obligatoria
Authors: Casillas-Martín Sonia , Cabezas-González Marcos , García-Valcárcel Muñoz-Repiso Ana 
Published: December 2020

Para que las investigaciones sobre la competencia digital puedan aportar información valiosa que contribuya a guiar las políticas educativas de desarrollo de la misma y de integración de las Tecnologías de la Información y la Comunicación en los sistemas educativos de los países, es necesario contar con instrumentos de recogida de información válidos y fiables.
El objetivo del presente trabajo es el de validar una prueba para evaluar la competencia digital en estudiantes de Educación Obligatoria, en los ámbitos de conocimiento, capacidad y actitud; teniendo como base el Marco para el Desarrollo y la Comprensión de la Competencia Digital en Europa. Este instrumento, diseñado por un equipo de investigación universitario, fue aplicado a una muestra de 771 estudiantes. Se analiza el índice de facilidad/dificultad de la prueba y por dimensiones, así como la validez y la fiabilidad. Se concluye que la prueba es original, novedosa y presenta unas buenas propiedades psicométricas que permiten calificarla como un instrumento fiable y válido para medir la competencia digital en todas sus dimensiones, de manera directa, mediante la reflexión sobre situaciones reales y la resolución de problemas.
Jaan Bergmanni pilaeepos „Jaaniida“: tekst, kontekst ja intertekst / Jaan Bergmann’s mock-epic Jaaniida: text, context and intertext
Authors: Lotman Maria-Kristiina , Lotman Rebekka 
Published: December 2020

Mock-epics were first created already in the antiquity and the most famous of them, the Batrachomyomachia, was translated into Estonian already in 1875 by Jaan Bergmann; it was also the first full translation of an ancient epic poem into Estonian. However, until now, no Estonian original mock-epics were known and this genre was presumed to have evolved in Estonian literature only in the 20th century, mostly used in parodies of the national epic, the Kalevipoeg.
In this issue, we introduce a new archival find from Jaan Bergmann’s manuscript poetry book. We discovered that, having probably been inspired by the Batrachomyomachia, but perhaps also by Nikolay Osipov’s Eneida (1791), Jaan Bergmann had created his own mock-heroic poem Jaaniida (1875). It is a multidimensional and poetically rich poem, interweaving different verse cultures and different eras. On the one hand, its analysis reveals clear influences of the Odyssey: there are parallels with the portrayal of the main hero, images and the plot, as well as with the Homeric epic techniques (for example, both epics begin with the prooemium, which contains an invocation). But in terms of poetic devices and versification, Jaaniida draws on Estonian folk songs, using the folk meter, plenty of alliteration and assonance as well as parallelism, and imitating their morphology and vocabulary. The storyline of the poem features events that appear to have happened only recently before the writing of the text (most probably in 1866–1875): the transition from villeinage to money rent and the cases of corruption among local administrators. Against this background, Bergmann satirically pictures the rise of an individual and his later downfall caused by his weaknesses and vices.
Muscle strength and inflammatory response to the training load in rowers
Authors: Podgórski Tomasz , Nowak Alicja , Domaszewska Katarzyna , Mączyński Jacek , Jabłońska Magdalena , Janowski Jarosław , Ogurkowska Małgorzata B. 
Published: December 2020

BackgroundRegular exercise leads to changes in muscle metabolism. The consequence of this is the adaptation to higher training loads.The aim of this study was to evaluate biomechanical and biochemical parameters describing the functions of skeletal muscles in periods when changes in training forms were introduced.MethodsSeventeen male sweep-oar rowers, members of the Polish national rowing team, participated. The study was carried out at the beginning and at the end of the preparatory period. In the first and second examination measurements of torques of selected muscle groups and blood biochemical analysis were performed.ResultsThere was observed a statistically significant decrease in the relative global force of the right lower limb between both terms of examination. A statistically significant increase in maximum torque was found for torso flexors. In the case of muscles responsible for torso rotation, a statistically significant decrease in the torque values of right torso rotators was observed. A significant difference was found with respect to creatine kinase activity, total testosterone concentration, total testosterone to cortisol ratio and total phenolics concentration (p < 0.05).ConclusionThe study shows that the rowers’ training should be more focused on building the strength of lower limbs to prevent the overload of lumbar spine and that the amount of force developed may be significantly affected by the antioxidant potential of rowers.
Long-term administration of vitamin B12 and adenosine triphosphate for idiopathic sudden sensorineural hearing loss: a retrospective study
Authors: Kurioka Takaomi , Sano Hajime , Furuki Shogo , Yamashita Taku 
Published: December 2020

Background
In idiopathic sudden sensorineural hearing loss (ISSNHL), the relationship between the administration duration of vitamin B12 (vit B12) with adenosine triphosphate (ATP) and their therapeutic effect is not fully understood.

Objective
To investigate the therapeutic effect of long-term 16 (≥weeks) administration of vit B12 with ATP on the prognosis of ISSNHL patients and compare it with those of short-term (<8 weeks) and middle-term (≥8 weeks, <16 weeks) administration.

Methods
We retrospectively reviewed the medical records of 117 patients with ISSNHL treated between 2015 and 2018.

Results
The overall recovery rate was 32.5%. Initial higher hearing threshold and initial higher grade of hearing loss (HL) were associated with a poor prognosis. However, the administration duration of vit B12 and ATP did not influence the overall hearing improvement. With regard to the time course of hearing recovery, there was no significant difference in hearing recovery among the long-, middle-, and short-term administration groups until 16 weeks after treatment. However, at 16–24 weeks after initial treatment, the short-term administration group exhibited significantly lower hearing recovery than did the long-term administration groups.

Conclusions
The administration duration of vit B12 and ATP did not influence the overall hearing prognosis in ISSNHL, but long-term administration of vit B12 and ATP helped prevent the progression of HL after ISSNHL. Our results suggest that long-term administration of vit B12 and ATP is not necessarily required to treat ISSNHL patients, except for slowly progressing HL in the affected ears.
Genomic and prognostic heterogeneity among RAS/BRAFV600E/TP53 co‐mutated resectable colorectal liver metastases
Authors: Berg Kaja C. G. , Brunsell Tuva H. , Sveen Anita , Alagaratnam Sharmini , Bjørnslett Merete , Hektoen Merete , Brudvik Kristoffer W. , Røsok Bård I. , Bjørnbeth Bjørn Atle , Nesbakken Arild , Lothe Ragnhild A. 
Published: December 2020

Hepatic resection is potentially curative for patients with colorectal liver metastases, but the treatment benefit varies. KRAS/NRAS (RAS)/TP53 co‐mutations are associated with a poor prognosis after resection, but there is large variation in patient outcome within the mutation groups, and genetic testing is currently not used to evaluate benefit from surgery. We have investigated the potential for improved prognostic stratification by combined biomarker analysis with DNA copy number aberrations (CNAs), and taking tumor heterogeneity into account. We determined the mutation status of RAS, BRAFV600, and TP53 in 441 liver lesions from 171 patients treated by partial hepatectomy for metastatic colorectal cancer. CNAs were profiled in 232 tumors from 67 of the patients. Mutations and high‐level amplifications of cancer‐critical genes, the latter including ERBB2 and EGFR, were predominantly homogeneous within patients. RAS/BRAFV600E and TP53 co‐mutations were associated with a poor patient outcome (hazard ratio, HR, 3.9, 95% confidence interval, CI, 1.3–11.1, P = 0.012) in multivariable analyses with clinicopathological variables. The genome‐wide CNA burden and intrapatient intermetastatic CNA heterogeneity varied within the mutation groups, and the CNA burden had prognostic associations in univariable analysis. Combined prognostic analyses of RAS/BRAFV600E/TP53 mutations and CNAs, either as a high CNA burden or high intermetastatic CNA heterogeneity, identified patients with a particularly poor outcome (co‐mutation/high CNA burden: HR 2.7, 95% CI 1.2–5.9, P = 0.013; co‐mutation/high CNA heterogeneity: HR 2.5, 95% CI 1.1–5.6, P = 0.022). In conclusion, DNA copy number profiling identified genomic and prognostic heterogeneity among patients with resectable colorectal liver metastases with co‐mutated RAS/BRAFV600E/TP53.
Design and Synthesis of a New Non‐Fullerene Acceptor for High‐Performance Photomultiplication‐Type Organic Photodiodes
Authors: Sim Hye Ryun , Kang Mingyun , Yu Seong Hoon , Nam Geon‐Hee , Lim Bogyu , Chung Dae Sung 
Published: December 2020

AbstractPhotomultiplication‐type organic photodiodes (PM‐OPDs) rely on acceptor molecules for both charge separation and efficient gain generation. Herein, a new non‐fullerene acceptor is designed and synthesized by introducing thienylenevinylene (TV) groups into the conventional 2,2ʹ‐[[6,6,12,12‐tetrakis(4‐hexylphenyl)‐6,12‐dihydrodithieno[2,3‐d:2ʹ,3ʹ‐dʹ]‐s‐indaceno[1,2‐b:5,6‐bʹ]dithiophene‐2,8‐diyl]bis[methylidyne(3‐oxo‐1H‐indene‐2,1(3H)‐diylidene)]]bis[propanedinitrile] (ITIC) structure. The resulting TV‐ITIC acceptor possesses not only extended π‐conjugation length, which leads to lower energy bandgap as well as deeper lowest unoccupied molecular orbital (LUMO) level, but also enhanced hydrophobic characteristics, owing to the increased volumetric portion of the aliphatic chain, which improves the miscibility with the donor polymer semiconductor, poly(3‐hexylthiophene‐2,5‐diyl) (P3HT). Moreover, pristine TV‐ITIC films consist of intrinsically well‐ordered anisotropic crystallites, which are confirmed by 2D grazing incidence X‐ray diffraction (2D‐GIXD) analysis. All of these photophysical properties are beneficial for efficient exciton separation, electron trapping, and charge injection abilities of PM‐OPDs compared to those obtained with conventional ITIC. Because of such synergetic contributions of TV‐ITIC to the photomultiplication mechanism, the resulting optimized PM‐OPD exhibits a high external quantum efficiency (>74,000%) and a large specific detectivity (>1012 Jones).
Catalase Inhibitors with Dual Pro‐Oxidant Effect as New Therapeutic Agents in Castration‐Resistant Prostate Cancer
Authors: Chen Yuan‐Yuan , Liang Hao‐Qi , Liu Meng‐Ting , Huang Wei , Yi Peng‐Fei , Yuan Si‐Qi , Mei Long‐Can , Hu Ying‐Hui , Cao Ya‐Ya , Hao Ge‐Fei , Zhang Dan , Yang Guang‐Fu 
Published: December 2020

AbstractAlmost all patients with advanced prostate cancer (PCa) will eventually progress to incurable castration‐resistant PCa (CRPC) if endocrine therapy fails. Therefore, identifying potential cellular targets is critical for the development of novel and effective treatments for CRPC. Based on the investigation of the molecular mechanism of ATN‐224, an anticancer drug in clinical trials, in CRPC DU145 cells, the antioxidant enzyme catalase (CAT) has been recognized as an actionable CRPC therapeutic target, and the modulation of intracellular redox state through CAT inhibition has great potential for CRPC treatment. After systematic design and synthesis, the benzaldehyde thiosemicarbazone derivative BT‐1 is shown to be effective CAT inhibitor in DU145 cells. This inhibition induces the significant increase of both superoxides (O2•−) and H2O2 levels in DU145 cells. Finally, the dual pro‐oxidant effect of BT‐1 is demonstrated to lead to apoptosis as well as cell‐cycle arrest in DU145 cells, effectively reducing CRPC tumors.
Local perceptions of mental health in Iran, Semnan Province
Authors: Baradaran Eftekhari Monir , Mahmoodi Zohreh , Dejman Masoumeh , Forouzan Ameneh Setareh , Falahat Katayoun , Shati Mohsen , Jandaghi Jafar , Kane Jeremy 
Published: December 2020

AbstractIntroductionUnderstanding local perceptions of mental health in different cultures and contexts is crucial for designing and implementing appropriate mental healthcare services.MethodsThis qualitative study was conducted to investigate local perceptions of mental health in two highly populated provincial districts in Iran. Data were collected using the free list technique and interviews. A two‐phase training workshop was held with the research team at a local health center, followed by a pilot study with the participation of six subjects. All the interviews were audio‐recorded, transcribed, and then analyzed by the third and fourth authors in DEDOOSE.ResultsA total of 30 individuals (20 in the free list and 10 as key informants in the interviews) took part in the study. Based on the study findings and the key informants' ideas, mental health problems were categorized into three categories of depression, anxiety, and obsessive–compulsive disorder (OCD).ConclusionsMental health problems appear to be expressed in different ways and with different symptoms in different cultures, and there is a distinct need for examining mental disorders in each culture and nationality separately using culturally appropriate tools for disease screening.
Effective inhibition of miR‐330/SHIP1/NF‐κB signaling pathway via miR‐330 sponge repolarizes microglia differentiation
Authors: Feng Yang , Li Tao , Xing Changyang , Wang Chen , Duan Yunyou , Yuan Lijun , Zhang Yajun 
Published: December 2020

AbstractNeuroinflammation mediated by microglia has been identified as vital pathogenesis in Parkinson's disease (PD). This study aimed to investigate the role and potential regulatory mechanism of microRNA‐330 in the lipopolysaccharide (LPS)‐induced chronic neuroinflammatory model. Primary microglia chronic inflammation model and PD animal model were established by LPS treatment. Bulged microRNA‐330 sponges containing six microRNA binding sites were constructed and delivered by plasmid or recombinant adeno‐associated virus (rAAV2)/5‐green fluorescent protein (GFP) vector. The expression levels of microRNA‐330 were assessed by a quantitative real‐time polymerase chain reaction. Primary microglia polarization was determined by flow cytometry; meanwhile, dopamine and pro‐(anti‐)inflammatory cytokines were measured by enzyme‐linked immunosorbent assay. Expression levels of GFAP, lba1, inducible nitric oxide synthase (iNOS), Arg1, SHIP1, cytoplasmic, and nuclear factor‐κB (NF‐κB) were analyzed by Western blot. The behavioral deficit was determined by the rotarod test. The expression of microRNA‐330 increased in the first 4 days and reached a plateau subsequently after LPS treatment. The sponges‐mediated repression effect on M1 polarization was gradually enhanced with time. Treatment of miR‐330 sponges increased the SHIP1 and Arg1 expression, and decreased the translocation of NF‐κB and iNOS expression, suggesting the repression of inflammation. In the LPS‐induced PD mice, administration of rAAV‐sponge‐GFP suppressed activation of microglia, downregulated proinflammatory cytokines, resumed the secretion of dopamine, rescued the dopaminergic neurons, and alleviated motor dysfunction. Our results demonstrated that microRNA‐330 sponges could sustainably suppress LPS‐induced polarization of microglia both in vivo and in vitro probably by negatively regulating NF‐κB activity via target SHIP1 in microglia, which might be a promising neuroprotective strategy in neurological diseases, such as PD.
Impella percutaneous left ventricular assist device as mechanical circulatory support for cardiogenic shock: A retrospective analysis from a tertiary academic medical center
Authors: Nouri Shayan Nabavi , Malick Waqas , Masoumi Amirali , Fried Justin A. , Topkara Veli K. , Brener Michael I. , Ahmad Yousif , Prasad Megha , Rabbani LeRoy E. , Takeda Koji , Karmpaliotis Dimitrios , Moses Jeffrey W. , Leon Martin B. , Kirtane Ajay J. , Garan A. Reshad 
Published: December 2020

AbstractObjectivesTo describe hemodynamic efficacy and clinical outcomes of Impella percutaneous left ventricular assist device (pLVAD) in patients with cardiogenic shock (CS).BackgroundPercutaneous LVADs are increasingly used in CS management. However, device‐related outcomes and optimal utilization remain active areas of investigation.MethodsAll CS patients receiving pLVAD as mechanical circulatory support (MCS) between 2011 and 2017 were identified. Clinical characteristics and outcomes were analyzed. A multivariable logistic regression model was created to predict MCS escalation despite pLVAD. Outcomes were compared between early and late implantation.ResultsA total of 115 CS patients (mean age 63.6 ± 13.8 years; 69.6% male) receiving pLVAD as MCS were identified, the majority with CS secondary to acute myocardial infarction (AMI; 67.0%). Patients experienced significant cardiac output improvement (median 3.39 L/min to 3.90 L/min, p = .002) and pharmacological support reduction (median vasoactive‐inotropic score [VIS] 25.4 to 16.4, p = .049). Placement of extracorporeal membrane oxygenation (ECMO) occurred in 48 (41.7%) of patients. Higher pre‐pLVAD VIS was associated with subsequent MCS escalation in the entire cohort and AMI subgroup (OR 1.27 [95% CI 1.02–1.58], p = .034 and OR 1.72 [95% CI 1.04–2.86], p = .035, respectively). Complications were predominantly access site related (bleeding [9.6%], vascular injury [5.2%], and limb ischemia [2.6%]). In‐hospital mortality was 57.4%, numerically greater survival was noted with earlier device implantation.ConclusionsTreatment with pLVAD for CS improved hemodynamic status but did not uniformly obviate MCS escalation. Mortality in CS remains high, though earlier device placement for appropriately selected patients may be beneficial.