bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pilot study of eruption forecasting with muography using convolutional neural network
Authors: Nomura Yukihiro , Nemoto Mitsutaka , Hayashi Naoto , Hanaoka Shouhei , Murata Masaki , Yoshikawa Takeharu , Masutani Yoshitaka , Maeda Eriko , Abe Osamu , Tanaka Hiroyuki K. M. 
Published: March 2020

AbstractMuography is a novel method of visualizing the internal structures of active volcanoes by using high-energy near-horizontally arriving cosmic muons. The purpose of this study is to show the feasibility of muography to forecast the eruption event with the aid of the convolutional neural network (CNN). In this study, seven daily consecutive muographic images were fed into the CNN to compute the probability of eruptions on the eighth day, and our CNN model was trained by hyperparameter tuning with the Bayesian optimization algorithm. By using the data acquired in Sakurajima volcano, Japan, as an example, the forecasting performance achieved a value of 0.726 for the area under the receiver operating characteristic curve, showing the reasonable correlation between the muographic images and eruption events. Our result suggests that muography has the potential for eruption forecasting of volcanoes.
CRISPR-based gene knockout screens reveal deubiquitinases involved in HIV-1 latency in two Jurkat cell models
Authors: Rathore Anurag , Iketani Sho , Wang Pengfei , Jia Manxue , Sahi Vincent , Ho David D. 
Published: March 2020

AbstractThe major barrier to a HIV-1 cure is the persistence of latent genomes despite treatment with antiretrovirals. To investigate host factors which promote HIV-1 latency, we conducted a genome-wide functional knockout screen using CRISPR-Cas9 in a HIV-1 latency cell line model. This screen identified IWS1, POLE3, POLR1B, PSMD1, and TGM2 as potential regulators of HIV-1 latency, of which PSMD1 and TMG2 could be confirmed pharmacologically. Further investigation of PSMD1 revealed that an interacting enzyme, the deubiquitinase UCH37, was also involved in HIV-1 latency. We therefore conducted a comprehensive evaluation of the deubiquitinase family by gene knockout, identifying several deubiquitinases, UCH37, USP14, OTULIN, and USP5 as possible HIV-1 latency regulators. A specific inhibitor of USP14, IU1, reversed HIV-1 latency and displayed synergistic effects with other latency reversal agents. IU1 caused degradation of TDP-43, a negative regulator of HIV-1 transcription. Collectively, this study is the first comprehensive evaluation of deubiquitinases in HIV-1 latency and establishes that they may hold a critical role.
Study of the biological function of LncRNA LUCAT1 on cervical cancer cells by targeting miR-199b-5p
Authors: Yang Ting , Xia Shengnan 
Published: March 2020

Abstract
To explore the effect and mechanism of LncRNA LUCAT1 in cervical cancer (CC). In the present study, 67 cases of CC patients and 60 healthy cases were selected as the research objects. CC patients were selected as the study group (SG) and healthy physical examination patients were selected as the control group (CG). LUCAT1 expression level in peripheral blood was detected in the two groups. Human cervical carcinoma cells C33A, AV3 and normal cervical epithelial cells H8 were purchased for biological behavior analysis. LUCAT1 was highly expressed in SG and cancer tissues (P&lt;0.050), and it had good diagnostic value for the development of CC (P&lt;0.001). It was closely related to the differentiation, pathological stage and metastasis of CC (P&lt;0.001). The prognosis of CC patients was affected (P&lt;0.050). After transfecting LUCAT1 into CC cells, it was found that the proliferation, invasion ability and anti-apoptosis protein of CC cells were significantly reduced, while the apoptosis rate and apoptosis protein were significantly increased by inhibiting LUCAT1 expression (P&lt;0.050). However, after transfecting miR-199b-5p into CC cells, it was found that the proliferation, invasion ability and anti-apoptosis protein of CC cells were significantly increased, while the apoptosis rate and apoptosis protein were significantly decreased by inhibiting LUCAT1 expression (P&lt;0.050). LUCAT1 was highly expressed in CC. It was involved in the tumor development of CC by targeting miR-199b-5p, which was of great significance for the diagnosis and treatment of CC in the future.
Wide field-of-view, high-resolution Solar observation in combination with ground layer adaptive optics and speckle imaging
Authors: Zhong Libo , Zhang Lanqiang , Shi Zhendong , Tian Yu , Guo Youming , Kong Lin , Rao Xuejun , Bao Hua , Zhu Lei , Rao Changhui 
Published: March 2020

Context. High angular resolution images at a wide field of view are required for investigating Solar physics and predicting space weather. Ground-based observations are often subject to adaptive optics (AO) correction and post-facto reconstruction techniques to improve the spatial resolution. The combination of ground layer adaptive optics (GLAO) and speckle imaging is appealing with regard to a simplification of the correction and the high resolution of the reconstruction. The speckle transfer functions (STFs) used in the speckle image reconstruction mainly determine the photometric accuracy of the recovered result. The STF model proposed by Friedrich Wöger and Oskar von der Lühe in the classical AO condition is generic enough to accommodate the GLAO condition if correct inputs are given. Thus, the precisely calculated inputs to the model STF are essential for the final results. The necessary input for the model STF is the correction efficiency which can be calculated simply with the assumption of one layer turbulence. The method for calculating the correction efficiency for the classical AO condition should also be improved to suit the GLAO condition. The generic average height of the turbulence layer used by Friedrich Wöger and Oskar von der Lühe in the classic AO correction may lead to reduced accuracy and should be revised to improve photometric accuracy.
Aims. This study is aimed at obtaining quantitative photometric reconstructed images in the GLAO condition. We propose methods for extracting the appropriate inputs for the STF model.
Methods. In this paper, the telemetry data of the GLAO system was used to extract the correction efficiency and the equivalent height of the turbulence. To analyze the photometric accuracy of the method, the influence resulting from the distribution of the atmospheric turbulence profile and the extension of the guide stars are investigated by simulations. At those simulations, we computed the STF from the wavefront phases and convolved it with the high-resolution numerical simulations of the solar photosphere. We then deconvolved them with the model STF calculated from the correction efficiency and the equivalent height to obtain a reconstructed image. To compute the resulting photometric precision, we compared the intensity of the original image with the reconstructed image. We reconstructed the solar images taken by the GLAO prototype system at the New Vacuum Solar Telescope of the Yunnan Astronomical Observatory using this method and analyzed the results.
Results. These simulations and ensuing analysis demonstrate that high photometric precision can be obtained for speckle amplitude reconstruction using the inputs for the model STF derived from the telemetry data of the GLAO system.
Chemical abundance analysis of extremely metal-poor stars in the Sextans dwarf spheroidal galaxy
Authors: Aoki M. , Aoki W. , François P. 
Published: March 2020

Context.Metal-poor components of dwarf galaxies around the Milky Way could be remnants of the building blocks of the Galactic halo structure. Low-mass stars that are currently observed as metal-poor stars are expected to have formed in chemically homogeneous clusters in the early phases of galaxy formation. They should have already disintegrated and should exhibit large scatter in abundance ratios of some sets of elements (e.g., Sr/Ba) in the Milky Way field stars. However, chemical abundance ratios are expected to cluster in very metal-poor stars in dwarf galaxies because the number of clusters formed in individual galaxies in the very early phase is expected to be quite limited.Aims.We examine the possible clustering of abundance ratios of Sr and Ba in the Sextans dwarf galaxy to test for the clustering star formation scenario.Methods.We investigate a total of 11 elements (C, Mg, Ca, Sc, Ti, Cr, Mn, Ni, Zn, Sr, Ba) in five stars in the Sextans dwarf galaxy. Previous studies suggest that these have similar abundance ratios. In this study, we focus on the abundance ratio of Sr to Ba. The observations are based on high-resolution spectroscopy (R= 40 000) using the Subaru Telescope High Dispersion Spectrograph.Results.The distribution ofα/Fe abundance ratios of the Sextans dwarf galaxy stars is slightly lower than the average of the values of stars in the Galactic halo. The Sr/Ba abundance ratios for the five metal-poor stars are in good agreement, and this clumping is distinctive compared to the [Sr/Ba] spread seen in the metal-poor halo stars. We find that the probability of such clumping is very small if the Sextans stars have distributions of Sr and Ba abundances similar to halo stars.Conclusions.In the Sextans dwarf galaxy, five out of six of the extremely metal-poor stars for which abundance ratios are well studied so far show clear clustering in abundance ratios including Sr/Ba. These observations tend to support the hypothesis that these stars were formed from a cloud of homogeneous chemical composition.
Subpelvine Stenose/Kreuzendes Gefäß – kontra vascular hitch
Authors: Szavay Philipp , Heyne-Pietschmann Marie , Zundel Sabine M 
Published: March 2020

ZusammenfassungDie Hydronephrose beim Kind ist zumeist bedingt durch eine (kongenitale) intrinsische Ureterabgangsstenose. Die von Anderson und Hynes etablierte „dismembered“ Nierenbeckenplastik stellt den Goldstandard in der operativen Therapie dar, sei es über einen offenen Zugang oder laparoskopisch (auch robotisch assistiert) bzw. retroperitoneoskopisch durchgeführt. Weniger häufig findet man – zumeist bei Patienten jenseits des Säuglingsalters − eine extrinsische Stenose als Ursache einer – dann zumeist – intermittierenden bzw. dynamischen Hydronephrose. Diese wird verursacht durch ein oder mehrere aberrierende Unterpolgefäße, welche den uretero-pelvinen Übergang obstruieren. Hierfür ist die operative Verlagerung des Gefäßes durch eine Tunnel-Plastik am Nierenbecken, die sog. „vascular hitch“-Operation, von Hellström beschrieben, in zunehmender Weise wieder etabliert worden. Die beiden Möglichkeiten der operativen Therapie werden nach wie vor kontrovers diskutiert. In der Literatur findet sich Evidenz dafür, dass bei Vorliegen eines Polgefäßes in bis zu 57 % zusätzlich eine intrinsische Stenose ist, in bis zu 100 % zumindest histologische Alterationen wie bei einer intrinsischen Stenose vorhanden sind. Der intraoperative Aspekt erlaubt keine Diskriminierung zwischen intrinsischer und extrinsischer Stenose, diese kann nur histologisch objektiviert werden. Bei der Durchführung eines „vascular hitch“ besteht daher das Risiko einer verbleibenden intrinsischen Stenose mit konsekutiver Abflussstörung und der Gefahr einer Partialfunktionsminderung. Auch kann durch den „vascular hitch“ selbst die Durchblutung der Niere kompromittiert werden. Die sog. „dismembered“ Nierenbeckenplastik vermeidet hingegen ein falsches Selektionieren der Patienten. Zudem ist sie mit hinreichender Evidenz belegt als ein Verfahren mit niedriger Komplikationsrate von 2 – 3 % und funktionell sehr guten Ergebnissen hinsichtlich des Erhalts der Partialfunktion und der Verbesserung der Abflussdynamik. Im Vergleich besteht in der Literatur kein vermehrtes Komplikationsrisiko gegenüber der „vascular hitch“-Operation. Daher bevorzugen wir die "dismembered" Nierenbeckenplastik als Methode der Wahl bei der Hydronephrose und dem Vorliegen eines aberrierenden Polgefäßes.
Structure, Reactivity, and Synthetic Applications of Sodium Diisopropylamide
Authors: Collum David B. , Woltornist Ryan A. , Ma Yun , Algera Russell F. , Zhou Yuhui , Zhang Zirong 
Published: March 2020

The 60-year history of sodium diisopropylamide (NaDA) is described herein. We review various preparations, solvent-dependent stabilities, and solution structures. Synthetic applications of NaDA reported to date are framed by a mechanism-driven approach, emphasizing selectivities when appropriate. We conclude with examples beyond metalation in which NaDA plays a central role and with a few thoughts on where future applications could be focused.1	Introduction2	Preparation and Physical Properties3	Solution Structures4	Reactivity and Mechanism4.1	Solvent Decomposition4.2	Alkene and Diene Metalation4.3	Arene Metalations4.4	Dehydrohalogenations5	Selectivity and Applications in Synthesis5.1	Picoline Metalations5.2	C–H Metalation5.3	Dehydrohalogenations5.4	Triflate Alkylation5.5	Allyl Ether Isomerizations5.6	Cyclic Allene Synthesis5.7	Epoxide Elimination5.8	Enolization5.9	Orthometalation6	Flow7	Catalysis8	Organosodium Salts and Secondary Applications9	Conclusion
Comparação das rotações medial e lateral do ombro entre não-atletas e atletas profissionais de squash
Authors: Vilela José Carlos Souza , Freitas Júnior de Haroldo Oliveira , Sérgio Thiago Rodrigues , Pádua Bruno Jannotti , Costa da Eduardo Louzada , Machado Thalles Leandro Abreu , Barbosa Tadeu Fonseca 
Published: March 2020

Resumo
Objetivo Comparar as rotações medial e lateral dos ombros e as distâncias entre o processo coracoide e a fossa cubital de indivíduos não atletas e de jogadores profissionais de squash.
Método O estudo transversal foi realizado entre março e agosto de 2017. Não atletas do sexo feminino e masculino (n = 628) foram selecionados no Serviço de Emergência Ortopédica da nossa instituição. Os critérios de inclusão foram: idade entre 18 e 60 anos, ausência de deficiências físicas ou cognitivas e ausência de dor nos membros superiores. Jogadores profissionais de squash (n = 30) de várias nacionalidades foram selecionados em um evento realizado em nossa cidade. Todos os atletas praticavam seu esporte em alto nível há > 10 anos e/ou 10.000 horas, e todos eram assintomáticos. Os dados demográficos e clínicos foram coletados por entrevista, enquanto os exames físicos e de ombro foram realizados por um único consultor ortopédico.
Resultados Em comparação com os não atletas, os jogadores profissionais de squash apresentaram perdas médias significativas (p < 0,001) de 23°34' na rotação interna e significativos (p < 0,003) ganhos médios de 10°23' na rotação externa dos ombros dominantes. Houve diferença significativa (p < 0,008) entre não atletas e atletas quanto à distância entre o processo coracoide e a fossa cubital no braço dominante.
Conclusão A participação intensiva no squash provoca alterações adaptativas que dão origem ao déficit de rotação interna glenoumeral, acompanhadas de significativo ganho de rotação externa, e podem gerar alterações patogênicas no ombro.
Ombro do arremessador: Artigo de atualização
Authors: Ejnisman Benno , Lara Paulo Henrique Schmidt , Ribeiro Leandro Masini , Belangero Paulo Santoro 
Published: March 2020

ResumoA maioria das lesões do ombro ocorre devido aos movimentos repetitivos acima do nível da cabeça. Antes de estudar o tratamento dessas lesões, é fundamental que os profissionais de saúde tenham um entendimento da etiologia e dos mecanismos que causam essas patologias. O ato do arremesso acima do nível da cabeça exige considerável coordenação de todo o corpo, desde o momento de geração de força até o final do arremesso. O ombro é um componente crucial da cadeia cinética da extremidade superior, por transmitir a força gerada na extremidade inferior para o braço e mão para produzir velocidade e precisão no lançamento da bola.
Valuation discourses and disciplinary positioning struggles of academic researchers—A case study of ‘maverick’ academics
Authors: Hah Sixian 
Published: March 2020

AbstractWhile it is known that researchers need to contend with increasing demands in the evolving landscape of higher education in the UK, few studies have examined how academic researchers discursively construct their struggles. This paper explores the valuation discourses that academic researchers draw upon to construct and account for their struggles in the process of establishing themselves as academics. It strives to answer the question: What kinds of struggles do academics face when positioning themselves and their research in relation to disciplines? What kinds of valuation discourses do academic researchers draw upon to position themselves as academics working in certain disciplines? The data comes from my PhD research, where I conducted 30 qualitative interviews with academic researchers ranging from PhD students, early career researchers to Professors Emeriti, who work in applied linguistics and language-related fields in UK universities. This paper focuses on two case studies of academics who positioned themselves as “mavericks” or who resist being pigeonholed in one discipline. In order to provide some comparative basis, the two case studies come from two ends of the academic career spectrum. I examine how they constructed their struggles with positioning themselves in relation to disciplines, and the kinds of valuation discourses evoked in the process. The paper proposes a model that conceptualizes how disciplinary positioning struggles are constructed by discursive acts and in the process, produce and reinforce valuation discourses about academic disciplines. Embedded in these disciplinary positioning struggles, researchers employed academic categories (Angermuller, 2017. High Educ 73(6):963–980) and evoked valuation discourses. The paper illustrates how academics hold valuation discourses about the kinds of disciplinary positioning practices that are valued, which may sometimes differ from the valuation discourses of fellow researchers, institutions and other stakeholders in higher education. The paper argues that such incongruence in valuation discourses between the individual and others result in positioning struggles.
First demonstration of a cryocooler conduction cooled superconducting radiofrequency cavity operating at practical cw accelerating gradients
Authors: Dhuley R C , Posen S , Geelhoed M I , Prokofiev O , Thangaraj J C T 
Published: March 2020

Abstract
We demonstrate practical accelerating gradients on a superconducting radiofrequency (SRF) accelerator cavity with cryocooler conduction cooling, a cooling technique that does not involve the complexities of the conventional liquid helium bath. A design is first presented that enables conduction cooling an elliptical-cell SRF cavity. Implementing this design, a single cell 650 MHz Nb3Sn cavity coupled using high purity aluminum thermal links to a 4 K pulse tube cryocooler generated accelerating gradients up to 6.6 MV m−1 at 100% duty cycle. The experiments were carried out with the cavity-cryocooler assembly in a simple vacuum vessel, completely free of circulating liquid cryogens. We anticipate that this cryocooling technique will make the SRF technology accessible to interested accelerator researchers who lack access to full-stack helium cryogenic systems. Furthermore, the technique can lead to SRF based compact sources of high average power electron beams for environmental protection and industrial applications. A concept of such an SRF compact accelerator is presented.
Changes of orbital electron correlations due to the coupling between quantum dots and Majorana zero modes
Authors: Gong Wei-Jiang , Gao Zhen , Li Xue-Si , Zhang Lian-Lian 
Published: March 2020

Abstract
We present a detailed analysis about the changes of the orbital electron-correlation effects in one quantum-dot circuit, by considering finite couplings between the quantum dots and Majorana zero modes (MZMs). It is found that the dot-MZM couplings complicate the orbital-Kondo effect, because the orbital correlation occurs between the localized states in the quantum dots and the continuum hybridized states induced by the indirect metal-MZM couplings. When two of such correlation exist in pair, they have an opportunity to induce a long-range RKKY correlation, which is related to the MZMs. Further investigation shows that this RKKY interaction leads to the anomalous fractional Josephson effect. Our work can be helpful in clarifying the influence of MZM on the orbital electron correlation effects.
Transport in magnetically doped one-dimensional wires: can the helical protection emerge without the global helicity?
Authors: Tsvelik A M , Yevtushenko O M 
Published: March 2020

Abstract
We study the phase diagram and transport properties of arbitrarily doped quantum wires functionalized by magnetic adatoms. The appropriate theoretical model for these systems is a dense one-dimensional Kondo lattice (KL) which consists of itinerant electrons interacting with localized quantum magnetic moments. We discover the novel phase of the locally helical metal where transport is protected from a destructive influence of material imperfections. Paradoxically, such a protection emerges without a need of the global helicity, which is inherent in all previously studied helical systems and requires breaking the spin-rotation symmetry. We explain the physics of this protection of the new type, find conditions, under which it emerges, and discuss possible experimental tests. Our results pave the way to the straightforward realization of the protected ballistic transport in quantum wires made of various materials.
Decoding of grasping tasks from intraneural recordings in trans-radial amputee
Authors: Cracchiolo Marina , Valle Giacomo , Petrini Francesco , Strauss Ivo , Granata Giuseppe , Stieglitz Thomas , Rossini Paolo M , Raspopovic Stanisa , Mazzoni Alberto , Micera Silvestro 
Published: March 2020

Abstract

Objective. A major challenge in neuroprosthetics is the restoration of sensory-motor hand functions in upper-limb amputees. Neuroprostheses based on the direct re-connection of the peripheral nerves may be an interesting approach for re-establishing the natural and effective bidirectional control of hand prostheses. Recent results have shown that transverse intrafascicular multi-channel electrodes (TIMEs) can restore natural and sophisticated sensory feedback. However, the potential of using TIME-recorded motor intraneural signals to decode grasping tasks has not as yet been explored. Approach. In this study, we show that several hand-movement intentions can be decoded from intraneural signals recorded using four TIMEs implanted in the median and ulnar nerves of an upper limb amputee. Experimental sessions were performed over a week, from day 16 to day 23 after the surgical operation. Intraneural activity was recorded during several hand motor tasks imagined by the subject and processed offline. Main results. We obtained a very high decoding accuracy considering 11 class states (up to 83%). These results confirm that neural signals recorded by multi-channel intraneural electrodes can be used to decode several movement intentions with high accuracy. Moreover, we were able to use same TIME channels for decoding over one week within the first month, even if the stability has to be confirmed during long-term experiments. Significance. Therefore, TIMEs could be used in the future to achieve a complete bidirectional approach exploiting neural pathways, to make a more natural and intuitive new generation of hand prostheses that have a closer resemblance to a healthy hand.