bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of doxorubicin-based and liposomal doxorubicin chemotherapies for patients with extra-abdominal desmoid-type fibromatosis: a systematic review
Authors: Shimizu Koki , Kawashima Hiroyuki , Kawai Akira , Yoshida Masahiro , Nishida Yoshihiro 
Published: June 2020

Abstract

Objective
The treatment modality for desmoid-type fibromatosis has shifted from surgery to conservative treatment. The guideline committee for clinical care of extra-abdominal desmoid-type fibromatosis in Japan conducted a systematic review of treatment with doxorubicin-based chemotherapy for desmoid-type fibromatosis.

Methods
We searched the pertinent literature. Two reviewers evaluated and screened it independently for eligibility and extracted data. They rated each report according to the grading of recommendations development and evaluation methodology. Based on the ‘body of evidence’, which the reviewers created, the clinical guideline committee decided a recommendation for the clinical question, ‘Is doxorubicin-based chemotherapy effective for patients with extra-abdominal desmoid-type fibromatosis?’

Results
Fifty-three articles were extracted by the literature search, and one from hand search. After the first and second screenings, five articles were subjected to the final evaluation. There were no randomized controlled trials. According to response evaluation criteria in solid tumors criteria, the response rates of doxorubicin-based regimens and liposomal doxorubicin were 44% (28.6–54) and 33.3% (0–75) on average, respectively. In two reports, the response rates of doxorubicin-based regimens were higher than those of non-doxorubicin-based ones; 54% vs 12%, 40% vs 11%, respectively. The rates of G3 or G4 complications according to common terminology criteria for adverse events were 28% and 13% with doxorubicin-based and liposomal doxorubicin chemotherapy, respectively, including neutropenia or cardiac dysfunction. None of the reports addressed the issue of QOL.

Conclusion
Although the evidence level was low in the evaluated studies, doxorubicin-based and liposomal doxorubicin chemotherapy was observed to be effective. However, doxorubicin-based chemotherapy is associated with non-ignorable adverse events, and is not covered by insurance in Japan. We weakly recommend doxorubicin-based chemotherapy for patients with extra-abdominal desmoid-type fibromatosis in cases resistant to other treatments.
Left lower limb fasciitis due to sigmoid colonic perforated diverticulitis: a rare case of colocutaneous fistula
Authors: Rubartelli Alice , Cocchi Lorenzo , Solari Nicola , Cafiero Ferdinando , Minuto Michele , Bertoglio Sergio 
Published: June 2020

Abstract
Up to 25% of patients with acute diverticulitis develop complicated disease. Colocutaneous fistula with lower limb fasciitis secondary to complicated diverticulitis is a rare event. A 71-year-old woman with Class 3 obesity and Type 2 diabetes was admitted to the hospital because of left lower limb fasciitis associated with acute sigmoid diverticulitis complicated by covered perforation. The fasciitis was treated with multiple fasciotomies, antibiotics and hyperbaric oxygen therapy. The patient was readmitted 25 days after discharge because of the formation of a left leg colocutaneous fistula associated with an enterocolic fistula. Patient underwent sigmoid resection with primary anastomosis and ileal loop repair. Three-month follow-up showed fistula healing and absence of symptoms. Fasciitis secondary to acute diverticulitis is a rare clinical scenario. Although our therapeutic strategy was successful, the optimal treatment timing and surgical technique for fasciotomy and colon resection remain to be assessed.
Modelling spectra of MN112
Authors: Kostenkov A , Fabrika S , Sholukhova O , Sarkisyan A , Bizyaev D 
Published: June 2020

ABSTRACT
MN112 is a Galactic luminous blue variable (LBV) candidate with a circumstellar nebula. P Cygni was the first LBV discovered, and was recorded during major eruptions in the 17th century. The stars have similar spectra with strong emission hydrogen lines, He i, N ii, Si ii, and Fe iii lines. We present the results of spectroscopic analysis and modelling of MN112 spectra. We obtained the main stellar parameters and chemical abundances of MN112 and compared them with those of P Cygni. Atmosphere models were calculated using the non-local thermodynamic equilibrium radiative transfer code cmfgen. We have used spectra of MN112 obtained with the 3.5-m telescope at the Observatory of Calar Alto and 3.5-m ARC telescope at the Apache Point Observatory. P Cygni spectra were taken with the 6-m BTA telescope. We have found the best fit of the observed spectrum with the model at temperature $T_{\text{eff}}= 15\, 200$ K, clumping-corrected mass-loss rate $\dot{M}f^{-0.5}=5.74 \times 10^{-5}\, \mathrm{M}_{\odot }\text{yr}^{-1}$, filling factor f = 0.1, luminosity $L=5.77 \times 10^5\, \mathrm{L}_{\odot }$ for MN112. The ratio of helium to hydrogen He/H is 0.27 (by the number of atoms) with nitrogen overabundance (XN/X⊙ = 6.8) and an underabundance of carbon (XC/X⊙ &lt; 0.1).
Non-linear dynamical tides in white dwarf binaries
Authors: Yu Hang , Weinberg Nevin N , Fuller Jim 
Published: June 2020

ABSTRACT
Compact white dwarf (WD) binaries are important sources for space-based gravitational-wave (GW) observatories, and an increasing number of them are being identified by surveys like Extremely Low Mass (ELM) and Zwicky Transient Facility (ZTF). We study the effects of non-linear dynamical tides in such binaries. We focus on the global three-mode parametric instability and show that it has a much lower threshold energy than the local wave-breaking condition studied previously. By integrating networks of coupled modes, we calculate the tidal dissipation rate as a function of orbital period. We construct phenomenological models that match these numerical results and use them to evaluate the spin and luminosity evolution of a WD binary. While in linear theory the WD’s spin frequency can lock to the orbital frequency, we find that such a lock cannot be maintained when non-linear effects are taken into account. Instead, as the orbit decays, the spin and orbit go in and out of synchronization. Each time they go out of synchronization, there is a brief but significant dip in the tidal heating rate. While most WDs in compact binaries should have luminosities that are similar to previous traveling-wave estimates, a few per cent should be about 10 times dimmer because they reside in heating rate dips. This offers a potential explanation for the low luminosity of the CO WD in J0651. Lastly, we consider the impact of tides on the GW signal and show that the Laser Interferometer Space Antenna (LISA) and TianGO can constrain the WD’s moment of inertia to better than $1{{\ \rm per\ cent}}$ for centi-Hz systems.
Sustaining a warm corona in active galactic nucleus accretion discs
Authors: Ballantyne D R , Xiang X 
Published: June 2020

ABSTRACT
Warm coronae, thick (τT = 10–20, where τT is the Thomson depth) Comptonizing regions with temperatures of ∼1 keV, are proposed to exist at the surfaces of accretion discs in active galactic nuclei (AGNs). By combining with the reflection spectrum, warm coronae may be responsible for producing the smooth soft excess seen in AGN X-ray spectra. This paper studies how a warm corona must adjust in order to sustain the soft excess through large changes in the AGN flux. Spectra from one-dimensional constant density and hydrostatic warm corona models are calculated assuming that the illuminating hard X-ray power law, gas density, Thomson depth, and coronal heating strength vary in response to changes in the accretion rate. We identify models that produce warm coronae with temperatures between 0.3 and 1.1 keV, and measure the photon indices and emitted fluxes in the 0.5–2 and 2–10 keV bands. Correlations and anticorrelations between these quantities depend on the evolution and structure of the warm corona. Tracing the path that an AGN follows through these correlations will constrain how warm coronae are heated and connected to the accretion disc. Variations in the density structure and coronal heating strength of warm coronae will lead to a variety of soft excess strengths and shapes in AGNs. A larger accretion rate will, on average, lead to a warm corona that produces a stronger soft excess, consistent with observations of local Seyfert galaxies.
The ram pressure stripped radio tails of galaxies in the Coma cluster
Authors: Chen Hao , Sun Ming , Yagi Masafumi , Bravo-Alfaro Hector , Brinks Elias , Kenney Jeffrey , Combes Francoise , Sivanandam Suresh , Jachym Pavel , Fossati Matteo , Gavazzi Giuseppe , Boselli Alessandro , Nulsen Paul , Sarazin Craig , Ge Chong , Yoshida Michitoshi , Roediger Elke 
Published: June 2020

ABSTRACT
Previous studies have revealed a population of galaxies in galaxy clusters with ram pressure stripped (RPS) tails of gas and embedded young stars. We observed 1.4 GHz continuum and H i emission with the Very Large Array in its B-configuration in two fields of the Coma cluster to study the radio properties of RPS galaxies. The best continuum sensitivities in the two fields are 6 and 8 µJy per 4 arcsec beam, respectively, which are 4 and 3 times deeper than those previously published. Radio continuum tails are found in 10 (8 are new) out of 20 RPS galaxies, unambiguously revealing the presence of relativistic electrons and magnetic fields in the stripped tails. Our results also hint that the tail has a steeper spectrum than the galaxy. The 1.4 GHz continuum in the tails is enhanced relative to their H α emission by a factor of ∼7 compared to the main bodies of the RPS galaxies. The 1.4 GHz continuum of the RPS galaxies is also enhanced relative to their infrared emission by a factor of ∼2 compared to star-forming galaxies. The enhancement is likely related to ram pressure and turbulence in the tail. We furthermore present H i detections in three RPS galaxies and upper limits for the other RPS galaxies. The cold gas in D100’s stripped tail is dominated by molecular gas, which is likely a consequence of the high ambient pressure. No evidence of radio emission associated with ultra-diffuse galaxies is found in our data.
Highly efficient ‘hit-and-run’ genome editing with unconcentrated lentivectors carrying Vpr.Prot.Cas9 protein produced from RRE-containing transcripts
Authors: Indikova Ivana , Indik Stanislav 
Published: June 2020

Abstract
The application of gene-editing technology is currently limited by the lack of safe and efficient methods to deliver RNA-guided endonucleases to target cells. We engineered lentivirus-based nanoparticles to co-package the U6-sgRNA template and the CRISPR-associated protein 9 (Cas9) fused with a virion-targeted protein Vpr (Vpr.Prot.Cas9), for simultaneous delivery to cells. Equal spatiotemporal control of the vpr.prot.cas9 and gag/pol gene expression (the presence of Rev responsive element, RRE) greatly enhanced the encapsidation of the fusion protein and resulted in the production of highly efficient lentivector nanoparticles. Transduction of the unconcentrated, Vpr.Prot.Cas9-containing vectors led to &gt;98% disruption of the EGFP gene in reporter HEK293-EGFP cells with minimal cytotoxicity. Furthermore, we detected indels in the targeted endogenous loci at frequencies of up to 100% in cell lines derived from lymphocytes and monocytes and up to 15% in primary CD4+ T cells by high-throughput sequencing. This approach may provide a platform for the efficient, dose-controlled and tissue-specific delivery of genome editing enzymes to cells and it may be suitable for simultaneous endogenous gene disruption and a transgene delivery.
Balloon Guide Catheter is Not Superior to Conventional Guide Catheter when Stent Retriever and Contact Aspiration are Combined for Stroke Treatment
Authors: Bourcier Romain , Marnat Gaultier , Labreuche Julien , Desal Hubert , Maria Federico Di , Consoli Arturo , Eugène François , Gory Benjamin , Dargazanli Cyril , Blanc Raphaël , Lapergue Bertrand ,   on behalf of the ETIS investigators
Published: June 2020

Abstract

BACKGROUND
The effectiveness of balloon guide catheter (BGC) use has not been prospectively studied and its added value for improving reperfusion in acute ischemic stroke (AIS) treatment has only been reported in studies in which no contact aspiration was combined with the stent retriever (CA + SR).

OBJECTIVE
To compare the reperfusion results and clinical outcomes with and without BGC use when a combined CA + SR strategy is employed in first line to treat AIS.

METHODS
From January 2016 to April 2019, data from the ETIS registry (Endovascular Treatment in Ischemic Stroke) were reviewed. We included patients having undergone endovascular treatment with a combined CA + SR strategy and use or not of a BGC according to the operator's discretion. We compared BGC and nonBGC populations with matching and inverse probability of treatment weighting propensity scores. Primary outcome was the final near-complete/complete revascularization (mTICI2c/3) rate. Secondary outcomes included clinical outcomes and safety considerations.

RESULTS
Among 607 included patients, BGC was used in 32.9% (n = 200), and 190 matched pairs could be found. We found no significant difference in final mTICI2c/3 between patients with and without BGC (60.1% in BGC group compared to 62.7% in nonBGC group (matched RR, 0.92; 95%CI, 0.80 to 1.14)), first-pass mTICI2c/3 (35.1% vs 37.3%, matched RR, 0.94; 95%CI, 0.68 to 1.30), clinical outcome (matched RR of 1.12 (95%CI, 0.85 to 1.47) for favorable outcome.

CONCLUSION
The reperfusion and clinical results with and without BGC use are not significantly different when combined CA + SR are used as a first-line strategy for large vessel occlusion in the setting of AIS.
Support for Minimum Legal Sales Age Laws Set to Age 21 Across Australia, Canada, England, and United States: Findings From the 2018 ITC Four Country Smoking and Vaping Survey
Authors: Hawkins Summer Sherburne , Chung-Hall Janet , Craig Lorraine , Fong Geoffrey T , Borland Ron , Cummings K Michael , Levy David , Hitchman Sara C 
Published: June 2020

Abstract

Introduction
Although the United States has seen a rapid increase in tobacco minimum legal sales age (MLSA) laws set to age 21, there is wide variation across high-income countries and less is known about policy support outside of the United States. We examined the prevalence of support for tobacco MLSA 21 laws as well as associations by sociodemographic, smoking, and household characteristics among current and former adult smokers.

Methods
In this cross-sectional analysis, we used the 2018 International Tobacco Control Four Country Smoking and Vaping Survey to examine support for MLSA 21 laws among 12 904 respondents from Australia, Canada, England, and United States.

Results
Support for raising the legal age of purchasing cigarettes/tobacco to 21 ranged from 62.2% in the United States to 70.8% in Canada. Endorsement also varied by age, such that 40.6% of 18–20 years old supported the policy compared with 69.3% of those aged ≥60 years. In the adjusted regression model, there was also higher support among respondents who were female than male, non-white than white, those who did not allow smoking in the household than those that did, and those who had children in the household than those that did not. There were no differences by household income, education, or smoking status.

Conclusions
Most current and former smokers, including a sizable minority of those aged ≤20 years, support raising the legal age of purchasing cigarettes/tobacco to 21.

Implications
There was strong support for MLSA 21 laws among smokers and former smokers across Australia, Canada, England, and the United States, providing evidence for the increasing public support of the passage of these laws beyond the United States.
The Clinical and Radiological Manifestations in Coronavirus Disease 2019 With Negative Nucleic Acid Results
Authors: Lang Guanjing , Su Junwei , Wu Wenrui , Zhao Hong , Ying Shihong , Lou Haiyan , Shen Xiaomin , Yin Michael T , Xu Kaijin , Liu Jun , Ren Cheng , Sheng Jifang 
Published: June 2020

Abstract

Background
Coronavirus disease 2019 (COVID-19) was a new emerging disease with high infectiousness. Its diagnosis primarily depended on real-time polymerase chain reaction (RT-PCR) results. This study investigated epidemiological, clinical, and radiological characteristics of COVID-19 with negative RT-PCR results before confirmation.

Methods
Patients with COVID-19 were enrolled and divided into 2 groups: a negative group with negative RT-PCR results before confirmation and a positive group with positive results at the first detection. Epidemiological and clinical features were compared. Dynamic chest computerized tomography (CT) images of the negative group were evaluated.

Results
Ninety-nine laboratory-confirmed patients with COVID-19 including 8 patients (8%) with negative RT-PCR results were included. Patients from the negative group had similar epidemiological features: the average age (50.25 ± 13.27 years in the negative group and 53.70 ± 16.64 years in the positive group) and gender distribution (males made up 50% of the negative group and 62.6% of the positive group) were comparable. No significant differences were observed in clinical symptoms between the 2 groups. We found that fever was the most common symptom for both groups, followed by cough, expectoration, chest distress, fatigue, and gastroenterological symptoms. Moreover, ground-glass opacities and consolidations were the main manifestation in chest CT of patients with COVID-19 with or without confirmed RT-PCR results.

Conclusions
Regardless of initial RT-PCR results, patients with COVID-19 had similar epidemiological, clinical, and chest CT features. Our study suggests value from early chest CT scans in COVID-19 screening and dynamic significance of radiology in disease monitoring should guide clinical decisions.
Justice in Automated Administration
Authors: Tomlinson Joe 
Published: June 2020

Abstract—
Public administration has, for some time now, been undergoing a digital transformation. Part of this change is the replacement of human public officials with automated decision-making systems. Beyond its immediate social and political significance, the EU Settlement Scheme—the mechanism established to allow EU citizens to remain resident in the UK after Brexit—represents the coming of age of a new template for automated administration. Understood in its context, this template raises foundational questions about the nature of administrative justice in the emerging digital state. This template, while it has various potential advantages, is essentially half-baked, contains significant risks without sufficient safeguards and requires revision before its suggested wider future application becomes a reality. Amendments to the template ought to be framed by reference to the precautionary principle, as this would continue to make for efficient implementation of policy while better protecting individuals in this experimental phase of automated administration.
ON A FORMULA FOR THE REGULARIZED DETERMINANT OF ZETA FUNCTIONS WITH APPLICATION TO SOME DIRICHLET SERIES
Authors: Hajli Mounir 
Published: June 2020

Abstract
In this paper, we study a large class of zeta functions. We evaluate explicitly the special values of these zeta functions and the associated derivatives at $0$. As an application, we recover several results on the zeta functions defined by two polynomials already obtained in the literature.
Difficult Bag-Mask Ventilation in Critically Ill Children Is Independently Associated With Adverse Events*
Authors: Daigle Curran Hunter , Fiadjoe John E. , Laverriere Elizabeth K. , Bruins Benjamin B. , Lockman Justin L. , Shults Justine , Krawiec Conrad , Harwayne-Gidansky Ilana , Page-Goertz Christopher , Furlong-Dillard Jamie , Nadkarni Vinay M. , Nishisaki Akira 
Published: June 2020

Objectives:
Bag-mask ventilation is commonly used prior to tracheal intubation; however, the epidemiology, risk factors, and clinical implications of difficult bag-mask ventilation among critically ill children are not well studied. This study aims to describe prevalence and risk factors for pediatric difficult bag-mask ventilation as well as its association with adverse tracheal intubation–associated events and oxygen desaturation in PICU patients.

Design:
A retrospective review of prospectively collected observational data from a multicenter tracheal intubation database (National Emergency Airway Registry for Children) from January 2013 to December 2018.

Setting:
Forty-six international PICUs.

Patients:
Children receiving bag-mask ventilation as a part of tracheal intubation in a PICU.

Interventions:
None.

Measurements and Main Results:
The primary outcome is the occurrence of either specific tracheal intubation–associated events (hemodynamic tracheal intubation–associated events, emesis with/without aspiration) and/or oxygen desaturation (< 80%). Factors associated with perceived difficult bag-mask ventilation were found using univariate analyses, and multivariable logistic regression identified an independent association between bag-mask ventilation difficulty and the primary outcome. Difficult bag-mask ventilation is reported in 9.5% (n = 1,501) of 15,810 patients undergoing tracheal intubation with bag-mask ventilation during the study period. Difficult bag-mask ventilation is more commonly reported with increasing age, those with a primary respiratory diagnosis/indication for tracheal intubation, presence of difficult airway features, more experienced provider level, and tracheal intubations without use of neuromuscular blockade (p < 0.001). Specific tracheal intubation–associated events or oxygen desaturation events occurred in 40.2% of patients with reported difficult bag-mask ventilation versus 19.8% in patients without perceived difficult bag-mask ventilation (p < 0.001). The presence of difficult bag-mask ventilation is independently associated with an increased risk of the primary outcome: odds ratio, 2.28 (95% CI, 2.03–2.57; p < 0.001).

Conclusions:
Difficult bag-mask ventilation is reported in approximately one in 10 PICU patients undergoing tracheal intubation. Given its association with adverse procedure–related events and oxygen desaturation, future study is warranted to improve preprocedural planning and real-time management strategies.