bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-performance printed electronics based on inorganic semiconducting nano to chip scale structures
Authors: Dahiya Abhishek Singh , Shakthivel Dhayalan , Kumaresan Yogeenth , Zumeit Ayoub , Christou Adamos , Dahiya Ravinder 
Published: October 2020

AbstractThe Printed Electronics (PE) is expected to revolutionise the way electronics will be manufactured in the future. Building on the achievements of the traditional printing industry, and the recent advances in flexible electronics and digital technologies, PE may even substitute the conventional silicon-based electronics if the performance of printed devices and circuits can be at par with silicon-based devices. In this regard, the inorganic semiconducting materials-based approaches have opened new avenues as printed nano (e.g. nanowires (NWs), nanoribbons (NRs) etc.), micro (e.g. microwires (MWs)) and chip (e.g. ultra-thin chips (UTCs)) scale structures from these materials have been shown to have performances at par with silicon-based electronics. This paper reviews the developments related to inorganic semiconducting materials based high-performance large area PE, particularly using the two routes i.e. Contact Printing (CP) and Transfer Printing (TP). The detailed survey of these technologies for large area PE onto various unconventional substrates (e.g. plastic, paper etc.) is presented along with some examples of electronic devices and circuit developed with printed NWs, NRs and UTCs. Finally, we discuss the opportunities offered by PE, and the technical challenges and viable solutions for the integration of inorganic functional materials into large areas, 3D layouts for high throughput, and industrial-scale manufacturing using printing technologies.
Application of deep learning in detecting neurological disorders from magnetic resonance images: a survey on the detection of Alzheimer’s disease, Parkinson’s disease and schizophrenia
Authors: Noor Manan Binth Taj , Zenia Nusrat Zerin , Kaiser M Shamim , Mamun Shamim Al , Mahmud Mufti 
Published: October 2020

AbstractNeuroimaging, in particular magnetic resonance imaging (MRI), has been playing an important role in understanding brain functionalities and its disorders during the last couple of decades. These cutting-edge MRI scans, supported by high-performance computational tools and novel ML techniques, have opened up possibilities to unprecedentedly identify neurological disorders. However, similarities in disease phenotypes make it very difficult to detect such disorders accurately from the acquired neuroimaging data. This article critically examines and compares performances of the existing deep learning (DL)-based methods to detect neurological disorders—focusing on Alzheimer’s disease, Parkinson’s disease and schizophrenia—from MRI data acquired using different modalities including functional and structural MRI. The comparative performance analysis of various DL architectures across different disorders and imaging modalities suggests that the Convolutional Neural Network outperforms other methods in detecting neurological disorders. Towards the end, a number of current research challenges are indicated and some possible future research directions are provided.
The impact of impression coping geometrical design on accuracy of implant impressions: an experimental study
Authors: Osman Motaz , Abubakr Neamat Hassan , Suliman Ahmed , Ziada Hassan 
Published: October 2020

Abstract
Aim
This in vitro study aimed to evaluate the effect of implant impression coping geometrical designs on the accuracy of open and closed impression techniques and in the parallel and nonparallel implant positions.

Material and methods
Three custom-made acrylic resin models of three tested implant systems (Straumann®, SIC Invent®, and Osstem®) with diverse coping geometrical designs were evaluated in simulated cases of two parallel and two nonparallel implants. The horizontal and vertical discrepancies were measured and analyzed.

Results
No statistically significant differences between the two impression techniques in either parallel or nonparallel implants were observed. The high retentive design of the Osstem system showed a statistically significant difference.

Conclusion
The geometrical design of the impression copings did not affect the accuracy for either the open and closed tray techniques. However, the high retentive coping design of the Osstem implant affected the accuracy in the open tray technique.
First month of the epidemic caused by COVID-19 in Italy: current status and real-time outbreak development forecast
Authors: Megna Rosario 
Published: October 2020

Abstract
Background
The first outbreak of COVID-19 in Italy occurred during the second half of February 2020 in some areas in the North of the country. Due to the high contagiousness of the infection, further spread by asymptomatic people, Italy has become in a few weeks the country with the greatest number of infected people in the world. The large number of severe cases among infected people in Italy led to the hospitalization of thousands of patients, with a heavy burden on the National Health Service.

Methods
We analyzed data provided daily by Italian Authorities for the period from 24 February 2020 to 30 March 2020. Considering such information, we developed a forecast model in real-time, based on the cumulative log-logistic distribution.

Results
A total of 101,739 infected individuals were confirmed until 30 March 2020, of which 14,620 recovered or discharged, and 11,591 deaths. Until the same date patients quarantined at home were 43,752, whereas hospitalized patients were 31,776, of which 3981 in intensive care. The active cases (i.e. the number of patients not yet recovered until that date) were 75,528. The forecast model estimated a number of infected persons for Italy of 234,000 about, and a duration of the epidemic of approximately 4 months.

Conclusions
One month after the first outbreaks there seemed to be the first signs of a decrease in the number of infections, showing that we could be now facing the descending phase of the epidemic. The forecast obtained thanks to our model could be used by decision-makers to implement coordinative and collaborative efforts in order to control the epidemic. The pandemic due to novel Coronavirus must be a warning for all countries worldwide, regarding a rapid and complete dissemination of information, surveillance, health organization, and cooperation among the states.
Antagonistic effects of some commonly used herbs on the efficacy of Artemisinin derivatives in the treatment of malaria in experimental mice
Authors: Idowu O. A. , Babalola A. S. , Olukunle J. 
Published: October 2020

Abstract
Background
The use of herbs in combination with drugs in treatment of malaria is increasing, and this necessitated research on the possible antagonistic, additive, potentiation or synergistic properties of commonly used plants with standard drugs in treatment of malaria. In this study, extracts of Morindamorindiodes (Mm) root, Morindalucida (ML) leaf and Vernonia amygdalina (Va) leaf were combined with artesunate (Ar) and assessed for anti-malarial activities against established Plasmodium berghei NK65 infection in 45 experimental mice randomly distributed into 9 groups and treated at a graded dose of 100 mg/kg for the herbs and herbs–drugs combination, while chloroquine and artesunate was administered at 10 mg/kg

Results
At the end the sixth day, Mm root extract, ML and Va leaf extract reduced parasitaemia by 86.83%, 84.20% and 48.10%, respectively (p < 0.05). A total parasite clearance (100% chemosuppression) was observed in the group treated with artesunate and chloroquine. However, the combination of each extracts of M. lucida, M. morindiodes and V. amygdalina with artesunate significantly reduced the chemosuppression to 89.93%, 89.43% and 86.93%, respectively.

Conclusion
This study showed that though the extracts of Morinda morindiodes and Morinda lucida possess convincing antiplasmodial effect when administered singly, the combination of these extracts with artesunate could not produce total parasite clearance. There is need to enlighten the public on the possible setback associated with combined use of antimalarial plants with antimalaria drugs.
Detrital zircon U–Pb geochronology and geochemistry of the Riachuelos and Palma Sola beach sediments, Veracruz State, Gulf of Mexico: a new insight on palaeoenvironment
Authors: Armstrong-Altrin John S. 
Published: October 2020

AbstractZircons are abundant in the beach sediments. In this study, surface microtexture, mineralogy, bulk sediment geochemistry, trace element composition and U–Pb isotopic geochronology of detrital zircons collected from the Riachuelos and Palma Sola beach areas, southwestern Gulf of Mexico were performed to infer the sediment provenance and palaeoenvironment. The zircon microtexture was categorized as mechanically- and/or chemically-induced features. The weathering index values for the Riachuelos (~ 72–77) and Palma Sola (~ 71–74) beach sediments indicated moderate weathering of both of the two source areas. The major and trace element data of bulk sediments suggested passive margin settings for the two areas. The trace elemental ratios and chondrite-normalized rare earth element (REE) patterns of bulk sediments revealed that the sediments were likely sourced by felsic and intermediate igneous rocks. And the zircon Th/U ratios (mostly more than 0.2) and zircon REE patterns (with negative Eu and positive Ce anomalies) suggested a magmatic origin for both of the beach sediments from these two areas. Two distinct zircon age peaks respectively belonging to the Paleozoic and the Cenozoic were identified both in the Riachuelos and Palma Sola beach sediments. Zircon geochronology comparison research between the Riachuelos–Palma Sola beach sediments and potential source areas in SW Gulf of Mexico revealed that the source terrane supplied the Paleozoic zircons of this study was identified as the Mesa Central Province (MCP), and the Cenozoic zircons were transported from the nearby Eastern Alkaline Province (EAP). Moreover, although the Precambrian zircons were very few in the studied sediments, their geochronology and geochemistry results still could infer that they were contributed by the source terranes of Grenvillian igneous suites in the Oaxaca and the Chiapas Massif Complexes.
The formation of authigenic deposits during Paleogene warm climatic intervals: a review
Authors: Banerjee Santanu , Choudhury Tathagata Roy , Saraswati Pratul Kumar , Khanolkar Sonal 
Published: October 2020

AbstractAlthough Paleogene warm climatic intervals have received considerable attention for atmospheric and oceanographic changes, the authigenic mineralization associated with these time spans remains overlooked. An extensive review of the literature reveals a close correspondence between the high abundance of glauconite and warm climatic intervals during the Paleogene period. The abundance of phosphorite, ironstone, lignite and black shale deposits reveals similar trends. Although investigated thoroughly, the origin of these authigenic deposits is never understood in the background of Paleogene warming climatic intervals. A combination of factors like warm seawater, hypoxic shelf, low rate of sedimentation, and enhanced rate of continental weathering facilitated the glauconitization. The last factor caused the excess supply of nutrients, including Fe, Si, K, Mg and Al through the rivers, the cations needed for the formation of glauconite. The excessive inflow of nutrient-rich freshwater into the shallow seas further ensured high organic productivity and stratification in shallow shelves, causing hypoxia. The consequent rapid rise in sea-level during the warm periods created extensive low-relief shallow marine shelves starved in sediments. Oxygen-deficiency in the shallow marine environment facilitated the fixation of Fe into the glauconite structure. The inflow of nutrient-rich water during the warm climatic intervals facilitated the formation of phosphorite, ironstone, and organic-matter-rich sedimentary deposits as well. Although global factors primarily controlled the formation of these authigenic deposits, local factors played significant roles in some of the deposits. Therefore, phosphorites formed in marine conditions with open circulation within the tropical zone. While lush growth of rainforest covers in the tropical belt facilitated the formation of coastal lignite.
Visible-light-driven photocatalytic degradation of rhodamine B using Bi2WO6/GO deposited on polyethylene terephthalate fabric
Authors: Du Zoufei , Cui Ce , Zhang Sihang , Xiao Hongyan , Ren Erhui , Guo Ronghui , Jiang Shouxiang 
Published: October 2020

Abstract
The environmental repercussions of wastewater from the dye process mean that it is very important to obtain an eco-friendly photocatalyst that would degrade wastewater. Herein, bismuth tungstate/graphene oxide (Bi2WO6/GO) composites are fabricated through in-situ hydrothermal reaction and then the Bi2WO6/GO photocatalysts are deposited onto polyethylene terephthalate (PET) fabric. The obtained Bi2WO6/GO deposited PET fabrics are then characterized through XPS, Raman, SEM, TEM, XRD, UV-vis, BET method and photoluminescence spectroscopy (PL) to investigate their chemical and crystal structures, morphology, optical property, surface area and photochemical properties. Photocatalytic performance is studied through examining the rate of degrading rhodamine B (RhB) under visible light. Surface of PET fibers is densely covered with Bi2WO6/GO. Bi2WO6/GO deposited PET fabrics show a broad absorption band in the visible spectra. Removal rate of RhB on the Bi2WO6/GO deposited PET fabric is the highest with the GO content of 2 g/L (labeled as Bi2WO6/2 g/LGO). The result of active species experiment shows that superoxide radicals (·O2−) plays a major role in the degradation of RhB. Moreover, Bi2WO6/2 g/LGO deposited PET fabric shows excellent cycle stability of photocatalytic degradation for RhB. The findings in this work can be extended to preparation other types of composite on the textile for photocatalysis, which can be applied to remove dyes in the wastewater produced by the textile or leather industry.

Graphical abstract
Profiling chromatin regulatory landscape: insights into the development of ChIP-seq and ATAC-seq
Authors: Ma Shaoqian , Zhang Yongyou 
Published: October 2020

AbstractChromatin regulatory landscape plays a critical role in many disease processes and embryo development. Epigenome sequencing technologies such as chromatin immunoprecipitation sequencing (ChIP-seq) and assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) have enabled us to dissect the pan-genomic regulatory landscape of cells and tissues in both time and space dimensions by detecting specific chromatin state and its corresponding transcription factors. Pioneered by the advancement of chromatin immunoprecipitation-chip (ChIP-chip) technology, abundant epigenome profiling technologies have become available such as ChIP-seq, DNase I hypersensitive site sequencing (DNase-seq), ATAC-seq and so on. The advent of single-cell sequencing has revolutionized the next-generation sequencing, applications in single-cell epigenetics are enriched rapidly. Epigenome sequencing technologies have evolved from low-throughput to high-throughput and from bulk sample to the single-cell scope, which unprecedentedly benefits scientists to interpret life from different angles. In this review, after briefly introducing the background knowledge of epigenome biology, we discuss the development of epigenome sequencing technologies, especially ChIP-seq & ATAC-seq and their current applications in scientific research. Finally, we provide insights into future applications and challenges.
Angiotensin-Converting Enzyme Inhibitors Reduce Uterine Fibroid Incidence in Hypertensive Women
Authors: Fischer Nicole M , Nieuwenhuis Tim O , Singh Bhuchitra , Yenokyan Gayane , Segars James H 
Published: October 2020

Absctract

Context
In vitro and in vivo evidence has supported the role of angiotensin II blockade in reducing leiomyoma cell proliferation and growth. However, no population-based study to date has investigated this potential association.

Objective
This work aims to determine whether prior angiotensin-converting enzyme inhibitor (ACEi) use is associated with a reduced odds of leiomyoma development.

Design
A nested case-control study was conducted.

Setting
The population was assembled from the Truven Health MarketScan Research Database, which includes private health insurance claims from January 1, 2012 to December 31, 2017.

Patients or Other Participants
We included (n = 353 917) women age 18 to 65 with hypertension. Cases (n = 13 108) with a leiomyoma diagnosis were matched to controls (n = 340 808) with no such diagnosis at a 1:26 ratio by age and region of origin within the United States.

Intervention
Prior ACEi use was determined from outpatient drug claims.

Main Outcome Measure
Leiomyoma development was indicated by a first-time diagnosis code.

Results
Women on an ACEi experienced a 31.8% reduced odds of developing clinically recognized leiomyoma compared to nonusers (odds ratio [OR] 0.68; 95% CI, 0.65-0.72). This association was significant for each age group: 30 to 39 years (OR 0.86; 95% CI, 0.74-0.99), 40 to 49 years (OR 0.71; 95% CI, 0.66-0.76), 50 to 59 years (OR 0.63; 95% CI, 0.58-0.69), and 60 to 65 years (OR 0.58; 95% CI, 0.50-0.69). Of the ACEis, lisinopril (OR 0.67; 95% CI, 0.64-0.71), quinapril (OR 0.62; 95% CI, 0.41-0.92), and ramipril (OR 0.35; 95% CI, 0.23-0.50) demonstrated a significant association with reduced leiomyoma incidence.

Conclusions
ACEi use was associated with a reduced odds of developing clinically recognized leiomyoma in adult hypertensive women.
Serum Irisin Levels in Central Precocious Puberty and Its Variants
Authors: Kutlu Esra , Özgen İlker Tolga , Bulut Huri , Koçyiğit Abdurrahim , Otçu Hafize , Cesur Yaşar 
Published: October 2020

Abstract

Aim
The exact mechanisms that trigger the onset of puberty are not well known. Adipomyokines are postulated to stimulate the central neural network. In the present study, we investigated irisin levels in girls with central precocious puberty (CPP), slowly progressing precocious puberty (SPPP), or premature thelarche (PT); we also studied prepubertal girls and to determine if this adipomyokine could be used as a marker in this context.

Methods
A total of 94 girls including 33 with CPP, 31 with precocious puberty (PP) variants (SPPP or PT), and 30 healthy controls were enrolled to the study. The mean irisin levels were compared between groups. The bivariate correlations of irisin levels with clinical and laboratory parameters were assessed. Multivariate linear regression analysis was performed to determine independent predictive factors of irisin levels.

Results
Irisin levels were higher in the CPP group compared with the other groups (CPP group: 723.25 ± 62.35 ng/mL; PP variants group: 529.60 ± 39.66 ng/mL; and control group: 325.03 ± 27.53 ng/mL) (P &lt; 0.001). Irisin levels were positively correlated with body mass index standard deviation scores (BMI-SDS), height-SDS, weight-SDS, bone age, uterus long axis, ovary size, baseline FSH and LH, and peak LH levels. Multivariate linear regression analysis revealed that irisin levels had the strongest correlation with peak LH. The other independent predictive factor of irisin levels was BMI-SDS.

Conclusions
The mean irisin levels were higher in patients with CPP compared with other groups. The results of this study imply that increased irisin levels may be used as a marker of CPP provided that these findings are confirmed in larger prospective studies.
Molecular basis for KDEL-mediated retrieval of escaped ER-resident proteins – SWEET talking the COPs
Authors: Newstead Simon , Barr Francis 
Published: October 2020

ABSTRACT
Protein localisation in the cell is controlled through the function of trafficking receptors, which recognise specific signal sequences and direct cargo proteins to different locations. The KDEL receptor (KDELR) was one of the first intracellular trafficking receptors identified and plays an essential role in maintaining the integrity of the early secretory pathway. The receptor recognises variants of a canonical C-terminal Lys-Asp-Glu-Leu (KDEL) signal sequence on ER-resident proteins when these escape to the Golgi, and targets these proteins to COPI- coated vesicles for retrograde transport back to the ER. The empty receptor is then recycled from the ER back to the Golgi by COPII-coated vesicles. Crystal structures of the KDELR show that it is structurally related to the PQ-loop family of transporters that are found in both pro- and eukaryotes, and shuttle sugars, amino acids and vitamins across cellular membranes. Furthermore, analogous to PQ-loop transporters, the KDELR undergoes a pH-dependent and ligand-regulated conformational cycle. Here, we propose that the striking structural similarity between the KDELR and PQ-loop transporters reveals a connection between transport and trafficking in the cell, with important implications for understanding trafficking receptor evolution and function.
Is it possible to estimate volume of bone defects formed on dry sheep mandibles more practically by secondarily reconstructing section thickness of cone beam computed tomography images?
Authors: Koç Alaettin , Kaya Sema 
Published: October 2020

Objectives: The purpose of this study was to evaluate the effect of section thickness on volume estimations of bone defects scanned using cone beam computed tomography (CBCT). Methods: 25 bone defects were prepared on sheep mandibles and scanned using a KaVo 3D eXam (KaVo Dental, Biberach, Germany) CBCT device. Section thickness of images were reconstructed at 0.25, 0.5, and 0.75 mm to estimate the volume of these defects using the semiautomatic segmentation method. The volume averages obtained using microcomputed tomography and Archimedes’ method served as reference values. The estimated volumes at each section thickness were compared with the actual volumes using the Friedman test. The accuracy of volume estimation was determined by the percentage error with respect to the reference values, and the mean absolute error (MAE) was calculated. Results: Volumetric values of bone defects obtained with CBCT at section thicknesses up to 0.5 mm were compatible with the actual volumes (p > 0.05). The percentage errors at section thicknesses of 0.25, 0.5, and 0.75 mm were −5.4%, −7.3%, and −13.1%, respectively. The mean absolute errors were 13.6 mm3, 15.7 mm3, and 18.2 mm3, respectively. Conclusions: The section thickness values of CBCT images can be increased to a reasonable level to obtain accurate volume estimation results and save time. The semiautomatic segmentation method can be used reliably for volume estimations of bone defects.