bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH SUHU PENGERINGAN KULIT BAGIAN LUAR DAN BAGIAN DALAM MANGGIS (Gracinia mangostana, L.) TERHADAP KANDUNGAN PROKSIMAT, ALKALOID DAN FLAVONOID
Authors: Widhyastini I. G. A. Manik 
Published: August 2020

The Effect of Drying on The Outer and Inner Skin of Mangosteen (Gracinia mangostana, L.) for the Content of Proximate Analysis, Alkaloid and Flavanoid Mangosteen (Garcinia mangostana,L.), is considered to be one of the leading exports commodity in which the peel has the major part (60,82% from the total weight of the fruit), the flesh of the fruit is the second (35,51), the rest are the leaf sheaths (3,67). The peel of the mangosteen is rich in antioxidant which is useful for human health and this potential hasn’t been used widely. The use of the peel of mangosteen need to be furtherly reviewed.The preliminary research aimed to figure out the optimum temperature for drying the outer and the inner skin of the mangosteen as a test to obtain the content of proximate analysis, alkaloid and flavanoid. The results of the proximate test was obtained that the water content of the outer skin with temperature of 70oC ;80oC; 90oC ;100oC, was between 7% to 10% while the water content for the inner skin was between 11% to 12%, dry mass of 1% to 3%, N content between 0,1% until 0,5%, carbohydrate content between 1% until 2,5%. The results of the alkaloid test showed that all of the experiment treatments revealed positive results as well as the flavonoid test. The highest content of alkaloid and flavonoid was obtained at a temperature of 80oC to dry the outer skin of the mangosteen.Key words: proximate analysis, antioxidant ,alkaloid and flavonoid ABSTRAK Manggis (Garcinia mangostana,L.), merupakan salah satu primadona ekspor yang menjadi andalan Indonesia Komponen terbesar dari buah manggis adalah kulit buah (60,82% dari berat buah utuh),daging buah merupakan komponen yang kedua (35,51% ), sisanya adalah komponen daun kelopak (3,67 % ). Kulit buah manggis, kaya akan senyawa antioksidan yang sangat bermanfaat bagi kesehatan manusia dan potensi ini belum dimanfaatkan secara luas.Pemanfaatan kulit buah manggis perlu dikaji lebih lanjut.Penelitian pendahuluan yang bertujuan untuk mengetahui suhu pengeringan optimal padakulit bagian luar dan kulit bagian dalam manggis terhadap kandunganproksimat, alkaloid dan flavonoid. Hasil uji proksimat diperoleh bahwa kadar air untuk kulit bagian luar masing-masing dengan suhu pengeringan 70oC ;80oC; 90oC ;100oC adalah berkisar dari 7 % sampai 10 % sedangkan kadar air pada kulit bagian dalam adalah berkisar dari 11 % sampai 12 %, kadar abu 1% sampai 3 %, kadar N berkisar antara 0,1 % sampai 0,5 %, kadar Karbohidrat berkisar antara 1% sampai 2,5 %. Hasil uji alkaloid menunjukkan bahwa semua perlakuan menunjukkan hasil positif demikian juga dengan hasil uji flavonoid. Kandungan alkaloid dan flavonoid terbanyak diperoleh pada pengeringan 80oC untuk kulit bagian luar dari manggis.Kata kunci: proksimat, antioksidan, alkaloid dan flavonoid
Reflection of Feminism in Veronica Roth's Divergent
Authors: Dianita Prasetyo Ningrum L. Dyah P. Wardani, 
Published: August 2020

Abstract Reflection of feminism is seen through the statements, ideas, and behaviors in Divergent novel. It is depicted through its major female characters. Those characters show their power, strength, and bravery which are different with women in common. In this research, I use the theory of literature by Rene Wellek and Austin Warren which is used to analyze the characterization through the major female characters in the novel which are constructed by Veronica Roth. Then, feminism by Simone de Beauvoir is applied to know how the social status of those major female characters is and how they have reflected feminism. Finally, this analysis will show to the readers about women's power. The analysis of the reflection of feminism in Divergent novel shows women also have the same rights as men, and women are not always subjugated. According to statements, behaviors, and ideas of feminism in the novel, it is shown that every woman actually can choose whatever they want depending on their own desire. Keywords: reflection, feminism, women's power, equal rights.
PERANCANGAN IKON WISATA BERBASIS POTENSI WILAYAH
Authors: Marwanto Aries Budi 
Published: August 2020

ABSTRAK Perancangan Ikon Wisata dilakukan di Embung “Mbah Mangun” Desa Juron, Kec. Nguter, Kab. Sukoharjo. Metode yang digunakan untuk merealisasikan rancangan dilakukan melalui metode eksplorasi, inspirasi dan elaborasi. Tahap eksplorasi meliputi pengumpulan data di lapangan, dokumentasi, kajian literatur dan wawancara. Tahap inspirasi dilakukan dalam pengembangkan gagasan atau pun konsep ide berdasarkan analisis data yang telah diperoleh. Tahap elaborasi pada kegiatan perancangan ini merupakan tahap kristalisasi ide dengan memperkuat konsep filosofi bentuk. Pada tahap ini sekaligus mempertimbangkan secara matang aspek-aspek realisasi perancangan yang berkaitan dengan tata letak ikon, material, konstruksi dan teknik perwujudan. Kata kunci: embung, ikon, wisata. ABSTRACT The design of the tourism icon is carried out in the “Mbah Mangun” Embung in Juron Village, Subdistrict Nguter, District Sukoharjo. The method used to realize the design is through exploration, inspiration and elaboration. The exploration includes data collection in the field, documentation, literature studies and interviews. Inspiration stage is carried out in developing ideas or concept of ideas based on the analysis of data that has been obtained. The elaboration stage in this design activity represents the crystallization of ideas by strengthening the concept of the philosophy of form. This stage also considers the aspects of design realization related to the layout of icons, materials, construction and embodiment techniques.Keywords: embung, icons, tour.
Bilgi Teknolojilerinin Çalışanların Performansına ve Motivasyonuna Etkisi: TRB1 Bölgesindeki KOBİ’lerde Bir Uygulama
Authors: GÜVEN Mehmet , ASLAN Mesut 
Published: August 2020

Günümüz ticari hayatının ve sosyal hayatın merkezine oturan önemli kavramların başında ‘’bilgi ve bilgi teknolojileri’’ kavramları gelmektedir. Bilgi teknolojilerinin ulaşmış olduğu önemli teknolojik seviyeler, bilginin düzenli bir şekilde üretilmesi ve hızlı yayılmasında önemli bir etken haline gelmiştir. Bilgi teknolojilerini kullanarak işletmeler seri üretim yapabilmekte ve daha düşük masrafla işlerini yürütebilmektedirler. Aynı zamanda işletmeler bu teknolojileri kullanarak işletme çalışanlarının performansı ve motivasyonu üzerinde de etkili olmaya çalışmaktadır. Bu makale çalışmasının amacı bilgi teknolojilerinin çalışanların motivasyonu üzerindeki etkilerini incelemektir. Hazırlanan makale çalışmasında, TRB1 bölgesinde (Malatya, Elazığ, Bingöl ve Tunceli) yer alan KOBİ’lerde bir anket çalışması yapılarak, günümüz bilgi teknolojilerinin çalışanların performansı ve motivasyonu üzerinde etkisinin olup olmadığı incelenmeye çalışılmıştır. Bu bölge Türkiye nüfusunun %2.2. ‘sini oluşturmaktadır.Anket uygulamasına 257’si erkek, 53’ü kadın olmak üzere toplamda 310 kişi katılım sağlamıştır. Verilerin analizi konusunda; tanımlayıcı istatistiksel frekans, yüzde, ortalama, standart sapma değerleri ile sunulmuştur. Ölçeğin güvenilirlik düzeyinin tespit edilebilmesi ve kategorik değişkenler arasındaki ilişkinin belirlenebilmesi için ki-kare analizi uygulanmıştır. Belirlenen değişkenler arasındaki ilişkinin tespit edilmesi için regresyon analizi uygulanmıştır.Yapılan anket uygulaması sonucunda, bilgi teknolojilerinin çalışanların üzerindeki yükleri hafiflettiğini ve Bilişim Teknolojilerinin KOBİ'lerde işletme performansı ve motivasyonuna olan etkilerinin sürekli ölçülmesi gerektiği sonucu elde edilmiştir. Ayrıca, katılımcıların, performans ve motivasyon düzeylerinin istatistiki olarak daha yüksek olduğu ve değişkenler arasında yüksek düzeyde ilişkinin var olduğu tespit edilmiştir.
De la crisis del pepino a la crisis del huevo. Aciertos y errores en la gestión de comunicación de crisis alimentarias
Authors: Rodríguez González María del Mar , Marauri Castillo Iñigo , Armentia Vizuete José Ignacio , Marín Murillo Flora 
Published: August 2020

Esta investigación nace con la voluntad de estudiar y comparar las distintas políticas de comunicación que se llevaron a cabo como parte de la gestión de dos crisis enmarcadas en el ámbito de la seguridad alimentaria: la crisis de los pepinos acontecida en 2011 como consecuencia de la bacteria E.coli y la crisis del huevo, originada en 2017 debido al uso del insecticida Fipronil. En ambos casos la estrategia comunicativa para informar de una crisis alimentaria diseñada por las diferentes instituciones, de acuerdo a los sistemas europeos y nacionales de control, fue determinante para su control, un proceso en el que los medios de comunicación tienen un papel protagonista. Se pondrán de manifiesto los errores y debilidades de las instituciones públicas, así como la efectividad de las diferentes acciones comunicativas, enmarcadas en estrategias de comunicación globales para informar sobre crisis, escándalos y alertas alimentarias. A través de un análisis de contenido, en el que prima lo cualitativo frente a lo cuantitativo, se concluye que la crisis del pepino marcó un antes y un después en la manera de gestionar la comunicación ante una crisis alimentaria, ya que se reforzaron los controles y el sistema de alertas. La gestión comunicativa de la crisis del huevo muestra las bondades de una política de comunicación proactiva, aunque revela que la falta de comunicación entre Estados sigue siendo un hecho con graves consecuencias para la salud y para la economía de los países afectados.
Effect of a COVID-19 on Social, Psychological, Economic and Health Conditions in Libya
Authors: Elgimati Yousef , Alrasheed Ahmed , Mohamed Bashir Abdalla 
Published: August 2020

The purpose of this paper was to measure the effect of a COVID-19 on social, psychological, economic, and health conditions in Libyan society. This study was undertaken through a questionnaire survey using the Google Form survey questionnaires in order to collect the data. A random sampling method was used from 1st June to 15th July 2020by obtaining greater insight into the issue. A result of this study revealed that the COVID-19 had a different effect on four dimensions (social, psychological economic, and health conditions). The findings of the study indicate that there is a small positive effect on social, middle, and above middle positive effects on psychological and economic respectively and high positive effect on health conditions with various percentages in Libyan society. This has been one of the first academic studies on the COVID-19 on social, psychological, economic, and health conditions addressed the Libyan society. Arguably, many of the areas covered in this study warrant more specific and in-depth investigation. The researchers hope that this paper will be beneficial to both Libyan people and the government in improving and developing the social aspects to avoid spreading COVID-19 in the future.
Cardiovascular Complications of Chimeric Antigen Receptor T-Cell Therapy: The Cytokine Release Syndrome and Associated Arrhythmias
Authors: Simbaqueba Cesar Clavijo , Aponte Maria Patarroyo , Kim Peter , Deswal Anita , Palaskas Nicolas L. , Iliescu Cezar , Jahangir Eiman , Yang Eric H. , Steiner Raphael E. , Lopez-Mattei Juan 
Published: August 2020

ABSTRACTIn recent years, cancer treatment has evolved, and new therapies have been introduced with significant improvement in prognosis. The immunotherapies stand out owing to their efficacy and remission rate. Chimeric antigen receptor (CAR) T-cell therapy is a part of this new era of therapies. Chimeric antigen receptor T-cell therapy is a form of adoptive cellular therapy that uses a genetically encoded CAR in modified human T cells to target specific tumor antigens in a nonconventional, non-major histocompatibility complex (MHC) protein presentation. Chimeric antigen receptor T-cell therapy successfully identifies tumor antigens and through activation of T cells destroys tumoral cells. It has been found to efficiently induce remission in patients who have been previously treated for B-cell malignancies and have persistent disease. As the use of this novel therapy increases, its potential side effects also have become more evident, including major complications like cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Cytokine release syndrome is a major systemic inflammatory process as a result of massive cytokine production by the proliferating and activated CAR T cells in which multiple interleukins and immune cells contribute to the inflammatory response. Cytokine release syndrome has been associated with cardiovascular life-threatening complications including hypotension, shock, tachycardia, arrhythmias, left ventricular dysfunction, heart failure, and cardiovascular death. Arrhythmias, among its major complications, vary from asymptomatic prolonged corrected QT interval (QTc) to supraventricular tachycardia, atrial fibrillation, flutter, and ventricular arrhythmias like Torsade de pointes. This article focuses on the cardiovascular complications and arrhythmias associated with CRS and CAR T-cell therapy.
RS3PE Following Treatment With Combination of Hormonal Therapies Plus Ipilimumab in a Patient With Metastatic Prostate Cancer
Authors: Kim Sang T. , Murphy William A. , Aparicio Ana , Subudhi Sumit K. 
Published: August 2020

ABSTRACT

Introduction
Immune checkpoint inhibitors (ICIs) are often associated with inflammatory toxicities known as immune-related adverse events (irAEs). Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is an atypical inflammatory arthritis. Herein, we report a case of RS3PE in a patient with metastatic prostate cancer who was receiving a combination of second-generation hormonal therapies plus ipilimumab.

Case Presentation
A 59-year-old man with metastatic prostate cancer developed sudden onset of pain and swelling of the right hand after 15 weeks of treatment with second-generation hormonal therapies plus three cycles of ipilimumab. Symptoms alternated to the left hand. Physical examination showed tender, pitting edema of the left hand with tenderness on the right second through fifth metacarpal phalangeal joints, leading to the diagnosis of RS3PE. Ipilimumab was withheld, and the RS3PE self-resolved; however, 1 month later, the patient had another flare of RS3PE. A bone scan showed active inflammation on bilateral wrists and hands. Methotrexate was initiated, and his symptoms resolved over a few days. Methotrexate was discontinued 2 months later, and RS3PE has been in complete remission. His prostate cancer progressed, and radium-223 treatment was initiated.

Conclusion
To the best of our knowledge, this is the first reported case of RS3PE after the combined second-generation hormonal therapy plus ipilimumab. Both rheumatologists and oncologists should be aware that RS3PE can develop as an irAE. Understanding the mechanism of ICI therapy–associated RS3PE is critical to identify predictive biomarkers and develop optimal therapeutic strategies that do not sacrifice antitumor immunity.
Case Report: Sustained Complete Response to PI3K Inhibition in a Patient with Metastatic Breast Cancer Harboring PIK3CA, NF1, and CDH1 Mutations
Authors: Chandran Elias A. , Kennedy Ian 
Published: August 2020

ABSTRACT
PIK3CA mutations resulting in disinhibition of the phosphoinositide 3-kinase (PI3K) pathway are present in approximately a third of estrogen receptor (ER)-positive breast cancer. Recent clinical trials of PI3K inhibition in PIK3CA-mutated metastatic breast cancer have shown improvement in progression-free survival of up to 11 months. We report a 68-year-old woman with metastatic ER-positive breast cancer with PIK3CA mutation who despite having disease progression after four lines of endocrine therapy (ET) attained a complete response (CR) after subsequent addition of a PI3K inhibitor. Remarkably, her CR is still maintained at 5 years. We believe this may be due to the co-occurrence of an NF1 mutation, which increases sensitivity to PI3K inhibition. Our case demonstrates restoration of sensitivity to ET by additional inhibition of PI3K, which resulted in exceptional disease response, far exceeding the expected duration. Hence, we believe that PI3K inhibition in addition to ET should be considered in patients with simultaneous PIK3CA and NF1 mutations.
Health Economic Publications From the Middle East and North Africa Region: A Scoping Review of the Volume and Methods of Research
Authors: Zrubka Zsombor , Rashdan Omar , Gulácsi László 
Published: August 2020

ABSTRACTIntroductionWe reviewed the scope of countries, diseases, technologies, and methods involved in the health economic evaluations published in the Middle East and North Africa (MENA) region.MethodsPRISMA guidelines were followed. A PubMed search was conducted up to December 15, 2019. English language full-text articles were included if they reported original research on humans; involved the local population from Algeria, Bahrain, Egypt, Iraq, Jordan, Kuwait, Lebanon, Libya, Morocco, Oman, Palestine, Qatar, Saudi Arabia, Syria, Tunisia, United Arab Emirates, or Yemen; reported costs; and involved a full or partial health economic analysis comparing alternative health technologies. Data on publication year, country of origin, disease area according to ICD-10, type of health technology, and applied methods were extracted.ResultsFrom 105 eligible articles, 57.1% were published between 2015 and 2019. Egypt (30.5%) and Saudi Arabia (27.6%) were the most frequently involved countries. Infectious diseases were most often studied (27.6%). The assessed technology was a system (eg, infection control, screening, coverage/access, hospital management, or healthcare delivery program) in 41.9% of studies. Cost-utility analysis (CUA) was the most frequent method (29.5%) and was growing rapidly. Health system perspective was adopted in 52.4% of studies, whereas societal perspective was scarce (8.6%). The majority of studies (46.7%) were published in Scimago Q1 journals. Over half of the studies (54.2%) did not report or did not have a funding source.ConclusionsFrom 2015, health economic analysis became more frequent in the MENA region, providing input to value-based health policy and financing. For further growth, in addition to the development of the institutional background, valid and more standardized local cost and outcome data should be available.
Pharmacy and Therapeutics Committee Preparedness Plan for COVID-19
Authors: Abu Esba Laila Carolina , Al-Abdulkarim Hana Abdullah , Alrushidan Ahmed , Al Harbi Mohammed 
Published: August 2020

ABSTRACT
As the Pharmacy and Therapeutics (P&T) committee acts as an advisory committee on therapeutic options, it is important during pandemics, such as the current Coronavirus disease 2019 pandemic, to quickly search the evidence, be able to select the most appropriate therapies despite the limited evidence, and make appropriate decisions related to which drugs to procure and stock. Potential therapies and recommendations to the P&T committee at a large healthcare institution as means of a preparedness plan are reviewed here.
دراسة مقارنة للنشاط الكهربائي للعضلة الصدرية العظيمة المتناظرة في تمرين الضغط على المسطبة المستوية باستعمال جهاز سميث والأثقال الحرة
Authors: Hamdan Abdullah Ghazi , Altay Usama 
Published: August 2020

هدفت الدراسة إلى قياس النشاط الكهربائي (المعدل والقمة) للعضلة الصدرية العظيمة لجهتي اليمين واليسار في تمرين الضغط على المسطبة المستوية باستعمال الأثقال الحرة وجهاز سميث، والتعرف على الفروق في النشاط الكهربائي للعضلة الصدرية العظيمة اليمين واليسار في تمرين الضغط على المسطبة المستوية باستعمال الأثقال الحرة وجهاز سميث وفي الشدد (50% و 75% و100%). واستعمل الباحث المنهج التجريبي بأسلوب المقارنة. وتم اختيار عينة البحث بالطريقة العمدية والمتمثلة باربعة طلاب من الممارسين لرياضة رفع الاثقال في كلية التربية البدنية وعلوم الرياضة/جامعة بغداد بوزن (69.38 ± 5.56) كغم، وبطول (171.52 ± 1.15) سم، وبعمر (20.25 ± 2.25) سنة. وتم اجراء اختبار الضغط على المسطبة المستوية (Bench Press) ثم يتم تنفيذ نفس الاختبار السابق ولكن باستعمال جهاز سميث وبالشدد (50% و 75% و 100% من الشدة القصوى) لكلا الاختبارين. واستعمل الباحث الحقيبة الإحصائية الجاهزة (SPSS) للحصول على نتائج البحث من خلال: الوسط الحسابي، والانحراف المعياري، والوسيط، ومعامل الالتواء، اختبار (t-test) للعينات المستقلة. اما نتائج البحث فلم تُظهر فروقاً معنوية بين العضلة الصدرية العظيمة اليمين واليسار في متغيري النشاط الكهربائي (المعدل والقمة) عند استعمال الاثقال الحرة وجهاز سميث. وحدوث زيادة مطردة في متغيري النشاط الكهربائي (المعدل والقمة)، بزيادة الشدة ولكلا طريقتي اداء التمرين بالاثقال الحرة وجهاز سميث ولكلا العضلتين الصدريتين العظيمتين اليمين واليسار، كما ظهرت الفروق كلها في العضلة الصدرية العظيمة اليمنى لصالح استعمال الاثقال الحرة. في حين ظهرت الفروق كلها في العضلة الصدرية العظيمة اليسرى لصالح استعمال جهاز سميث. وأوصى الباحث باستعمال جهاز سميث او الاثقال الحرة لتطوير قوة العضلات الصدرية، واجراء دراسات للتأكد من سبب ظهور الفروق لمصلحة احدى الطريقتين دون الاخرى وذلك عن طريق اشراك لاعبين تكون الذراع المسيطرة عندهم هي الذراع اليسرى.
Modern Specialists’ Readiness
to Professional Communication and the Ways
of Developing Professional COmmunication Skills
Authors: Богомолова Е.В. , Ананьева О.И. 
Published: August 2020

В статье описано, каким образом можно решить проблему сущности профессионального общения и путей его эффективного формирования. На основе проведенного анализа определены методологические основы исследования, даны авторские определения понятий «парадигма образования», «профессиональное общение», «готовность к профессиональному общению». Обосновано и доказано, что формирование готовности современного специалиста к профессиональному общению на базе комплексного использования личностно ориентированного и синергетического подходов, персонолизированного обучения, синергии форм, методов и средств обучения обеспечивает целостность и системность подготовки, достижение высокого уровня компетентности в сфере профессионального общения.
The article focuses on the essence of professional communication and on efficient ways of developing professional communication skills. The investigation enables the authors to define methodological foundations for research. The authors provide their definitions of the following concepts: “educational paradigm”, “professional communication”, “readiness to professional communication”. The article maintains that to ensure modern specialists’ readiness to professional communication, to secure systematic and comprehensive training, to guarantee the quality formation of professional communication, it is essential to integrate personality-oriented and synergistic approaches and to ensure personalized education and synergistic relationship between forms, methods and means of education.