bluuebunny/crossref_metadata_2025_split huggingface dataset:
Capitalizing on Differences: Keys to Unlocking the Academic Achievement Gap
Authors: Byrd Marie 
Published: February 2020

Abstract
Closing the U.S. academic achievement gap is as complex as it is comprehensive due to the disproportion of instructional opportunities available to underserved student populations. Underserved student populations are defined as minority and/or students of color from low-socioeconomic families and communities, English language learners and recent immigrants (Wolniak, Flores, & Kemple, 2016). Raising the academic achievement of culturally, racially and ethnically diverse students from high poverty and/or high-risk communities will require more than national and/or state policies and mandates. It necessitates a transformative view of the teacher as a change agent with the ability to alter the culture, climate and level of student achievement in a classroom. This capacity-based method extends beyond what is readily identifiable by acknowledging the variances in approaches to teaching all students through research-based best practices to capitalize on differences. The approach presented allows for the focus on student variation in an inclusive setting to enhance academic achievement.
Recht und soziale Bewegung: Wege zu einem neuen Dialog
Authors: Israël Liora 
Published: February 2020

ZusammenfassungLange war die soziale Bewegungsforschung von einer Abwesenheit des Rechts als Phänomen, und umgekehrt, die Rechtssoziologie durch eine Abwesenheit der Forschung über soziale Bewegungen gekennzeichnet. Dieser doppelten Forschungslücke hat man sich in den letzten Jahren angenähert. Forschungen haben sich etwa mit der gesellschaftlichen Bezugnahme auf und der „Verwendung“ des Rechts beschäftigt, mit dessen politischer Mobilisierung, mit dem Engagement von JuristInnen in sozialen Bewegungen, aber auch mit Rechtsentwicklungen, wie sie als Ergebnis von Kämpfen sozialer Bewegungen zustande kommen. Im Beitrag wird eine Synthese dieser verschiedenen Forschungsrichtung zum Thema Recht und kollektive Aktion vorgenommen, um von hier aus neue Wege für weitere Forschungen zu diskutieren.
Kv4.1, a Key Ion Channel For Low Frequency Firing of Dentate Granule Cells, Is Crucial for Pattern Separation
Authors: Kim Kyung-Ran , Lee Seung Yeon , Yoon Sang Ho , Kim Yoonsub , Jeong Hyeon-Ju , Lee Sanghyeon , Suh Young Ho , Kang Jong-Sun , Cho Hana , Lee Suk-Ho , Kim Myoung-Hwan , Ho Won-Kyung 
Published: February 2020

The dentate gyrus (DG) in the hippocampus may play key roles in remembering distinct episodes through pattern separation, which may be subserved by the sparse firing properties of granule cells (GCs) in the DG. Low intrinsic excitability is characteristic of mature GCs, but ion channel mechanisms are not fully understood. Here, we investigated ionic channel mechanisms for firing frequency regulation in hippocampal GCs using male and female mice, and identified Kv4.1 as a key player. Immunofluorescence analysis showed that Kv4.1 was preferentially expressed in the DG, and its expression level determined by Western blot analysis was higher at 8-week than 3-week-old mice, suggesting a developmental regulation of Kv4.1 expression. With respect to firing frequency, GCs are categorized into two distinctive groups: low-frequency (LF) and high-frequency (HF) firing GCs. Input resistance (Rin) of most LF-GCs is lower than 200 MΩ, suggesting that LF-GCs are fully mature GCs. Kv4.1 channel inhibition by intracellular perfusion of Kv4.1 antibody increased firing rates and gain of the input-output relationship selectively in LF-GCs with no significant effect on resting membrane potential andRin, but had no effect in HF-GCs. Importantly, mature GCs from mice depleted of Kv4.1 transcripts in the DG showed increased firing frequency, and these mice showed an impairment in contextual discrimination task. Our findings suggest that Kv4.1 expression occurring at late stage of GC maturation is essential for low excitability of DG networks and thereby contributes to pattern separation.SIGNIFICANCE STATEMENTThe sparse activity of dentate granule cells (GCs), which is essential for pattern separation, is supported by high inhibitory inputs and low intrinsic excitability of GCs. Low excitability of GCs is thought to be attributable to a high K+conductance at resting membrane potentials, but this study identifies Kv4.1, a depolarization-activated K+channel, as a key ion channel that regulates firing of GCs without affecting resting membrane potentials. Kv4.1 expression is developmentally regulated and Kv4.1 currents are detected only in mature GCs that show low-frequency firing, but not in less mature high-frequency firing GCs. Furthermore, mice depleted of Kv4.1 transcripts in the dentate gyrus show impaired pattern separation, suggesting that Kv4.1 is crucial for sparse coding and pattern separation.
Synaptic Plasticity Depends on the Fine-Scale Input Pattern in Thin Dendrites of CA1 Pyramidal Neurons
Authors: Magó Ádám , Weber Jens P. , Ujfalussy Balázs B. , Makara Judit K. 
Published: February 2020

Coordinated long-term plasticity of nearby excitatory synaptic inputs has been proposed to shape experience-related neuronal information processing. To elucidate the induction rules leading to spatially structured forms of synaptic potentiation in dendrites, we explored plasticity of glutamate uncaging-evoked excitatory input patterns with various spatial distributions in perisomatic dendrites of CA1 pyramidal neurons in slices from adult male rats. We show that (1) the cooperativity rules governing the induction of synaptic LTP depend on dendritic location; (2) LTP of input patterns that are subthreshold or suprathreshold to evoke local dendritic spikes (d-spikes) requires different spatial organization; and (3) input patterns evoking d-spikes can strengthen nearby, nonsynchronous synapses by local heterosynaptic plasticity crosstalk mediated by NMDAR-dependent MEK/ERK signaling. These results suggest that multiple mechanisms can trigger spatially organized synaptic plasticity on various spatial and temporal scales, enriching the ability of neurons to use synaptic clustering for information processing.SIGNIFICANCE STATEMENTA fundamental question in neuroscience is how neuronal feature selectivity is established via the combination of dendritic processing of synaptic input patterns with long-term synaptic plasticity. As these processes have been mostly studied separately, the relationship between the rules of integration and rules of plasticity remained elusive. Here we explore how the fine-grained spatial pattern and the form of voltage integration determine plasticity of different excitatory synaptic input patterns in perisomatic dendrites of CA1 pyramidal cells. We demonstrate that the plasticity rules depend highly on three factors: (1) the location of the input within the dendritic branch (proximal vs distal), (2) the strength of the input pattern (subthreshold or suprathreshold for dendritic spikes), and (3) the stimulation of neighboring synapses.
Aprendizaje de las matemáticas por medio del movimiento: una alternativa más de la educación física
Authors: Serrano Madrigal Ariana , Azofeifa Lizano Ana , Araya Vargas Gerardo 
Published: February 2020

estudiantes de preparatoria, después de aplicar actividades físico recreativas relacionadas con contenidos de matemáticas a uno de ellos y juegos recreativos al otro. Participaron 27 sujetos (13 niñas y 14 niños), con edades entre 5 y medio y 6 y medio años. El instrumento que se utilizó fue un cuestionario sobre elementos fundamentales de las matemáticas, basados en los temarios del Ministerio de Educación Pública de Costa Rica; como lo fueron, geometría, operaciones básicas con elementos concretos y conocimiento del reloj. Una vez confeccionado el instrumento se realizó un plan de actividades físico recreativas relacionadas a las matemáticas, el cual fue desarrollado durante un mes y medio con el grupo experimental (preparatoria B). Para el análisis de los datos se utilizó tanto estadística descriptiva como inferencial. Se encontraron efectos significativos y positivos del programa de actividades físico recreativas sobre el rendimiento de los y las estudiantes en 10 de los 12 ítems que fueron aplicados para valorar el dominio de conceptos básicos de las matemáticas. Se puede concluir que al utilizar la educación física como un instrumento más para el aprendizaje de otras disciplinas, representa una excelente alternativa para los docentes de preescolar que buscan satisfacer las necesidades de aprendizaje de los niños y niñas que pronto irán a la escuela. El movimiento por medio de experiencias guiadas y planeada, es parte indispensable en la vida de los niños y niñas, por lo tanto, el aprendizaje de materias académicas debe adaptarse a la necesidad del niño(a) de explorar y conocer su entorno.
Challenges Conveying Clinical Equipoise and Exploring Patient Treatment Preferences in an Oncology Trial Comparing Active Monitoring with Radiotherapy (ROAM/EORTC 1308)
Authors: Sherratt Frances C. , Brown Stephen L. , Haylock Brian J. , Francis Priya , Hickey Helen , Gamble Carrol , Jenkinson Michael D. , Young Bridget 
Published: February 2020

Abstract

Introduction
Providing balanced information that emphasizes clinical equipoise (i.e., uncertainty regarding the relative merits of trial interventions) and exploring patient treatment preferences can improve informed consent and trial recruitment. Within a trial comparing adjuvant radiotherapy versus active monitoring following surgical resection for an atypical meningioma (ROAM/EORTC-1308), we explored patterns in communication and reasons why health practitioners may find it challenging to convey equipoise and explore treatment preferences.

Materials and Methods
Qualitative study embedded within ROAM/EORTC-1308. Data were collected on 40 patients and 18 practitioners from 13 U.K. sites, including audio recordings of 39 patients’ trial consultations, 23 patient interviews, and 18 practitioner interviews. Qualitative analysis drew on argumentation theory.

Results
Practitioners acknowledged the importance of the research question that the trial aimed to answer. However, they often demonstrated a lack of equipoise in consultations, particularly with eligible patients who practitioners believed to be susceptible to side effects (e.g., cognitive impairment) or inconvenienced by radiotherapy. Practitioners elicited but rarely explored patient treatment preferences, especially if a patient expressed an initial preference for active monitoring. Concerns about coercing patients, loss of practitioner agency, and time constraints influenced communication in ways that were loaded against trial participation.

Conclusions
We identified several challenges that practitioners face in conveying equipoise and exploring patient treatment preferences in oncology, and particularly neuro-oncology, trials with distinct management pathways. The findings informed communication about ROAM/EORTC-1308 and will be relevant to enhancing trial communication in future oncology trials. Qualitative studies embedded within trials can address difficulties with communication, thus improving informed consent and recruitment. ROAM/EORTC-1308 RCT: ISRCTN71502099.
The PALBONET Trial: A Phase II Study of Palbociclib in Metastatic Grade 1 and 2 Pancreatic Neuroendocrine Tumors (GETNE-1407)
Authors: Grande Enrique , Teulé Alex , Alonso-Gordoa Teresa , Jiménez-Fonseca Paula , Benavent Marta , Capdevila Jaume , Custodio Ana , Vera Ruth , Munarriz Javier , La Casta Adelaida , Díez Juan José , Gajate Pablo , Molina-Cerrillo Javier , Matos Ignacio , Cristóbal Eva María , Ruffinelli José C. , Palacios José , García-Carbonero Rocío 
Published: February 2020

AbstractLessons LearnedPalbociclib demonstrated no detectable activity in molecularly unselected and heavily pretreated patients with advanced grade 1/2 pancreatic neuroendocrine tumors. Predictive biomarkers that improve patient selection should be investigated in future studies of palbociclib.BackgroundPalbociclib, a CDK4/6 inhibitor, has shown in vitro activity in pancreatic neuroendocrine tumor (pNET) cell lines. Here we prospectively assessed the activity and safety of palbociclib in monotherapy in metastatic refractory pNETs.MethodsThis was a nonrandomized, open-label, phase II study of patients with metastatic grade (G)1/2 pNETs recruited from 10 centers in Spain. Palbociclib 125 mg was orally administered once daily for 21 of 28 days until disease progression or unacceptable toxicity.ResultsTwenty-one patients were included; 52.4% were men, and median age was 57.4 years (range, 37.4–73.4). Patients had previously received a median of three prior lines of systemic therapy (range, 1–10) for advanced disease (somatostatin analogues, 71.4%; sunitinib, 81.0%; everolimus, 47.6%; chemotherapy, 47.6%). Nineteen patients were evaluated for objective response rate (ORR), with a median follow-up of 12.4 months (range, 7.53–19.33). No objective and confirmed responses were observed (0%); 11 (57.9%) patients had stable disease, and 6 of them lasted more than 6 months; 8 (42.1%) patients had disease progression as best response. Median progression-free survival (PFS) was 2.6 months (95% confidence interval [CI], 0–14.4) and median overall survival (OS) was 18.7 months (95% CI, 7.4–29.9; Fig. 1). Most frequent toxicities of any grade were asthenia (76.2%), neutropenia (42.9%), diarrhea (33.3%), and nausea (33.3%). Five (23.8%) patients developed G3–4 neutropenia and two (9.5%) patients developed G3–4 thrombocytopenia.ConclusionLack of activity was observed with palbociclib as a single agent in molecularly unselected and heavily pretreated patients with advanced G1/2 pNETs.
The Contribution of A.E. Nadeina, Ayan Merchant of the Second Guild, to the Economic Development and Social Life of North-Eastern Siberia at the Beginning of the 20th Century
Authors: Kushnareva Margarita 
Published: February 2020

There is a growing interest among scientists and general public to the historical experience of the functioning of merchant enterprises on the eastern borders of the Russian Empire. The article analyzes the contribution of A.E. Nadeina, the Ayan merchant of the Second guild, to the economic development and social life on the eastern outskirts of Siberia at the beginning of the 20-th century. The key issue of the article is interdisciplinary and it combines the knowledge of history and economics. The study used method of content analysis, which involves the quantitative and qualitative analysis of statistical data sources, using mathematical modeling. The primary method is the analysis of memoirs and epistolary. The research identified main types of activity of A.E. Nadeina’s enterprise, determined economic indicators and evaluated the firm’s contribution to the economic development of coastal areas of North-Eastern Siberia by industry. The study found that the main contribution of A.E. Nadeina to the economic development of North-Eastern Siberia was the creation of transport infrastructure along the coast of the Sea of Okhotsk, and cargo transportation between the ports of Ayan and Nelkan. The annual profit of the transport enterprise of A.E. Nadeina was 20 thousand rubles. Gold exploration and development of forest resources, organized by A.E. Nadeina, were of strategic importance to the economic development of the region. Exploration and registration of new gold reserves, sale of timber forest annually contributed more than 5 thousand rubles to local economy providing means for its diversification. Fur trade of A.E. Nadeina was organized according to the classical scheme of loan on goods. The annual turnover of the enterprise reached 100–150 thousand rubles. To boost fur trade A.E. Nadeina created business ties with large firms, established a group of fur suppliers, provided transport service for commercial operations and developed fur resources of the region. In conclusion, it is necessary to note her contribution to social life of North-Eastern Siberia. A.E. Nadeina supported local education initiatives, commissioned the construction of a new school, and organized public events for the residents of Ayan and Nelkan.
Extracting the Response of the Bay Bridge, California, from the Application of Multichannel Deconvolution to Earthquake-Induced Shaking
Authors: Jian Jing , Snieder Roel , Nakata Nori 
Published: February 2020

ABSTRACTEngineered structures, such as bridges, are excited by earthquakes at the base of the towers and the endpoint of decks. The different structural units of bridges, such as the towers and decks, are coupled. We extract the response of the towers and decks of the Bay Bridge in California from the motion of the bridge that is caused by earthquakes. This constitutes a multichannel deconvolution problem, which is, in general, ill-posed. We use the redundancy of the western half of the Bay Bridge, with near-identical towers and decks, to estimate the response of the upper towers, lower towers, and decks, from the transverse motion recorded in the bridge after four earthquakes. The extracted response functions for the four earthquakes show consistent wave arrivals that correspond to the waves that propagate through the towers and the decks. This method can, in principle, be used to monitor changes in the structural response.
Pendekatan kriminologi dan gender terhadap model kurikulum pembinaan narapidana anak kelas I Blitar
Authors: Saifullah Saifullah , Bashith Abdul , Ch Mufidah 
Published: February 2020

This study is aimed to elaborate the criminology and gender approaches taken to provide curriculum material contents in forming curriculum models for fostering child detainees in the child prison. Using legal and conceptual approaches, this study elaborates the findings as follows: in the criminology perspective, to provide curriculum material contents in forming curriculum models for fostering child detainees in child prison is by using religious approach, completing facilities and infrastructures, optimizing employee roles, applying formal education in prison, giving treatment and health care, supporting for the creation of social recovery, giving remission of crimes and assimilated opportunities including a leave to visit family or parole and a leave before being released. Whereas, in the gender perspective, it is by not distinguishing between sexes during the treatment to them. In addition, the final result of the curriculum model formation for fostering child detainees in child prison of LPKA (Child-specific Guidance Institution) in Blitar can be referred to as; the treatment system for correctional students in prison. This system consists of input in the form of an initial stage of 0 to 1/3 course with an administrative orientation pattern; the advanced stage consists of 1/3 to ½ course and ½ to 2/3 course; the final stage is 2/3 to any uncertain course stage with the achievement of correctional goal that is social reintegration: live, life, livelihood.
Endometrioma e infertilidad: revisión de alternativas terapéuticas
Authors: Restrepo-Cano Gustavo Adolfo 
Published: February 2020

Objetivo: realizar una revisión de la literatura sobre el tratamiento de los endometriomas en el área de la infertilidad.Materiales y métodos: el presente trabajo es una revisión sistemática cualitativa, para la cual se realizó una búsqueda electrónica en PubMed/ MEDLINE, Hinari y Cochrane, para recopilar información publicada tanto en inglés como en español desde febrero del 2000 a marzo del 2010, eligiendo aquellos artículos que evaluaban el tratamiento de los endometriomas en función de la infertilidad.Resultados: la mejor evidencia respecto al manejo de los endometriomas en infertilidad se encuentra en las diferencias de las técnicas quirúrgicas para su tratamiento. La cistectomía laparoscópica es el método quirúrgico más efectivo, afecta de menor manera la reserva ovárica folicular y disminuye de forma significativa el riesgo de recurrencias. No afecta los resultados de la FIV (fertilización in vitro) en términos de embarazos.Conclusiones: la cirugía excisional laparoscópica (cistectomía) de los endometriomas ofrece ventajas frente a las demás.
Embarazo heterotópico: diagnóstico ecográfico temprano, manejo con laparoscopia. Reporte de un caso y revisión de la literatura
Authors: Mendivil César , Padrón Rafael , Miranda Jezid , Silva Glenda 
Published: February 2020

Objetivo: realizar una revisión de la literatura acerca de los aspectos más importantes relacionados con el diagnóstico oportuno y el manejo del embarazo heterotópico.Materiales y métodos: se presenta un caso de un embarazo heterotópico diagnosticado por ultrasonografía, a quien se le realizó salpingectomía por laparoscopia y se continuó con la gestación intrauterina normal. Se realizó una revisión en las bases de datos MEDLINE y EMBASE, además de la base latinoamericana SciELO y libros de la especialidad.Conclusión: el diagnóstico del embarazo heterotópico es difícil debido a las diversas manifestaciones clínicas y a la existencia del embarazo intrauterino que continúa la producción de fracción Beta de la gonadotropina coriónica humana. La ecografía es un pilar importante en el diagnóstico e identificación temprana de esta patología. La laparoscopia surge como una alternativa segura en el manejo.
Value of tissue Doppler imaging and peak acceleration time in prediction of paroxysmal atrial fibrillation in patients with paroxysmal atrial fibrillation
Authors: KELEŞ Fikret , ÇELİK Mustafa , KARATAS Recep , ERSEÇGİN Ahmet , YİLMAZ Ahmet , AYGUL Nazif , AVCI Ahmet 
Published: February 2020

Aim: Atrial
fibrillation is the most common arrhythmia in the population and its prevalance
increases with age; and also is the most morbid and mortal arrhythmia. Usually
the beginning of the persistant atrial fibrillation is recurrent episodes of
the paroxysmal atrial fibrillation (PAF). Prediction of the paroxysmal atrial
fibrillation can cause prevention of this arrhythmia and thus prevention of the
adverse outcomes. We aimed to investigate tissue Doppler imaging (TDI) and peak
acceleration time (pkAcc) parameters that can predict the paroxysmal atrial
fibrillation in this study.

Material and Methods: 20-73
years old (mean 47,5) 50 individuals that are diagnosed with PAF included the
patient group. 50 individuals who have the similar baseline demographic
charasteristics with patient group and who have no persistant or PAF included
the control group. Transthoracic echocardiogaphic (TTE) evaluation is applied
all of the control and study groups. Tissue Doppler parameters and pkAcc is
measured in TTE and statistical analyses is performed.

Results: In
TTE evaluation, left atrium ejection fraction is lower in the patient group
than the study group (%50,6 vs. %59,2, p&lt;0,001). In TDI evaluation, the
average of E/E’ which was measured from the anterior, inferior, lateral and
septal walls of the left ventricle; is found higher in the patient group
compared to the control group (8,17 vs. 7,04; p=0,004). When two groups are compared in terms of
pkAcc, it was found that patient group is higher, but this difference did not
reach the statistical significance (1063 vs. 994, p=0,14).

Conclusions: TDI
evaluation can play an important role in prediction of paroxysmal atrial
fibrillation.
ŞEREFE KARŞI SUÇLAR
Authors: KÖKEN Enes 
Published: February 2020

Şerefe Karşı Suçlar, TCK’nın İkinci Kitabının, Kişilere Karşı Suçlar başlıklı İkinci Kısmının, Sekizinci Bölümünde, 125-131. Maddeler arasında
düzenlenmiştir. Şeref, kişinin toplum içindeki saygınlığını ifade eder.
Hakaret ise, kişileri toplum içinde aşağılamak, rencide etmek, küçük düşürmektir. Şeref ve hakaretin gerçekleşmesi için gerekli şartlar, koşullar ve
özellikleri incelenecektir. Huzurda ve gıyapta hakaret suçlarının arasındaki farklar, bu hususların özellikleri detaylı olarak ele alınacaktır. Yine,
hakaret suçunun, suçun özel görünüş şekilleri açısından değerlendirilmesi yapılacaktır. Ayrıca, manevi unsurdan da bahsedilecektir. Madde 129,
öneminden dolayı ayrıca ele alınıp, değerlendirilecektir. Çalışmamızda,
özellikle doktrindeki tartışmalı noktalara ve daha önce üzerinde hiç veya
gereği kadar görüş bildirilmemiş konulara değinmeye çalışacağız.