bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loving Wisdom: The Ἀγαπάω-Φιλέω Exchange in John 21:15–17 as an Allusion to LXX Proverbs 8:17
Authors: Himes Paul Aaron 
Published: November 2020

Abstract
Though the majority of scholars argue against semantic distinction between ἀγαπάω and φιλέω in John 21:15–17 (recent articles by Shepherd and Böhler being significant exceptions), the oddity of the double juxtaposition of the two terms does not so easily vanish away. But rather than arguing for semantic distinction, this article proposes a neglected intertextual solution to the anomaly: John 21:15–17 is an allusion to the Old Greek version of Prov 8:17, and the significance of the two verbs lies in their discourse function, not difference in meaning. “Parallelomania” can be avoided due to the relative rarity of a juxtaposed ἀγαπάω-φιλέω in the LXX and the fact that the context of Prov 8–9 contains similar themes to John 20–21’s context, namely, the “banquet,” “seeking-and-finding,” and “mutual love” motifs, increasing the possibility of deliberate intertextuality (especially in light of potential Wisdom allusions elsewhere in John). The final section of this article examines both the theological role played by such an allusion to Prov 8:17 and how this coheres with the rest of John’s Gospel.
The Complex Relationship Among Truth, Argument, and Narrative
Authors: Stroud Scott R. 
Published: November 2020

ABSTRACTWhat are the obstacles to believing that narratives can argue? How can we be assured that narratives argue well? This article will explore major objections to accounts of narrative argument and literary truth, and explore a theory of narrative reasoning that emphasizes identification as a vital part of argument. In exploring the account of narrative offered by Walter Fisher in light of concerns with narrative in rhetorical studies and philosophy, I explicate a renewed sense of identification and narrative reasoning that can meet many of these objections to giving narrative a role in human communication and argument. Of particular interest are the resources available in narratives for active identification by an auditor or reader as good reasons for action or belief in their own extratextual activities.
Woekeren met andermans talent
Authors: Nelen Hans 
Published: November 2020

Taking advantage of other people’s talent. On the behaviour and self-image of football agents
The focus of this article is on the role that football agents play in the world of professional football. Their role has also been associated with criminal activities such as money laundering, tax evasion, corruption and the exploitation of under-age players. The article pays attention to recent developments in the world of football and the shady business practices in relation to the transfer of football players. Moreover, the article addresses the self-image of football agents and raises the question whether they should take more responsibility themselves in containing fraud and money laundering in the world of football.
Waarom dronepiloten toch in no fly zones vliegen
Authors: Wassenburg Stephanie , Beke Tess , Pret Han , Müller Barbara 
Published: November 2020

Waarom dronepiloten toch in no fly zones vliegen
Een scherpe stijging in het aantal drones en snelle vorderingen in dronetechnologie creëren nieuwe mogelijkheden en risico’s voor veiligheid en privacy. Door een beperkte toezichtcapaciteit is er behoefte aan gedragsinterventies die spontane naleving stimuleren. Het huidige onderzoek beschrijft psychologische factoren, zoals weerstand, die het regelnalevingsgedrag van dronepiloten beïnvloeden omtrent vliegen in no fly zones (gebieden waar men niet met een drone mag vliegen). De gemodelleerde antwoorden van 843 dronepiloten laten zien dat twee typen weerstand, inertie en scepticisme, invloed hebben op het gedrag van dronepiloten. Dit artikel beschrijft hoe deze inzichten door toezichthouders kunnen worden gebruikt om gewenst gedrag te bevorderen.
Animalismo e non violenza. L’incidenza della lezione gandhiana sul pensiero di Tom Regan
Authors: Battaglia Luisella 
Published: November 2020

In opposition to the anthropocentric model of domination, in Gandhi as in Regan there is the full recovery of an ethical-philosophical tradition based on the model of kinship or fraternity and that insists on the possibility of extending the rules of justice to all living beings. The result of this perspective is the duty of vegetarianism and the radical opposition to any practice that treats animals as means at the service of human interests. But Gandhi’s lesson is particularly useful both to address the properly political issues arising from animal ethics, that are at the heart of Regan’s philosophy (starting with the debate on the nature and justification of animal rights theories and their possible inclusion in the political community), and to define the most appropriate non-violent fighting strategies for the achievement of the aims of animal rights defenders.
Effects of personality on the developmental trajectories of academic burnout among Korean medical students
Authors: Chae Han , Cloninger C. Robert , Lee Soo Jin 
Published: November 2020

Background
Medical students have a high risk of burnout from tremendous academic stress, and previous cross-sectional studies have explained this risk from the personality perspective. However, the relationship between complex personality profiles and developmental trajectory of burnout has not been delineated yet.

Methods
The longitudinal changes in burnout were measured by the Maslach Burnout Inventory-Student Survey (MBI-SS) at baseline (1st week), mid-term (9th week), and end-term (17th week), and personality was examined at baseline using the Temperament and Character Inventory (TCI). Latent trajectory groups based on the MBI-SS total scores were extracted using the General Growth Mixture Model (GGMM), and significant differences in personality profiles among the latent groups were identified using profile analysis and Analysis of Variance.

Results
Three burnout trajectory groups of high-increasing (HI), moderate-increasing (MI), and low-stable (LS) were identified, and these groups had significantly different TCI subscale profiles. The HI group had the highest score in Harm-Avoidance (HA) and lowest score in Self-Directedness (SD), and the MI group had a higher score in HA and lower scores in SD and Cooperativeness (CO) when compared to the LS group with the lowest score in HA and highest scores in SD and CO.

Conclusion
The current study showed that the HA, SD, and CO subscales of the TCI might explain the longitudinal development of academic burnout in medical students. Prevention of burnout and promotion of well-being in medical education concerning personality are discussed.
Wellenlängengesteuerte Adaption der Hydrogeleigenschaften durch Photodynamische Multivalenz in Assoziierenden Sternpolymeren
Authors: Ludwanowski Simon , Skarsetz Oliver , Creusen Guido , Hoenders Daniel , Straub Paula , Walther Andreas 
Published: November 2020

AbstractResponsive Materialien, wie z. B. schaltbare Hydrogele, wurden in den meisten Fällen dahingehend entworfen, eine maximale Änderung zwischen zwei Zuständen zu generieren. Im Gegensatz dazu zielen adaptive Systeme auf unterschiedliche funktionelle Plateaus zwischen diesen Maxima ab. In diesem Forschungsartikel zeigen wir daher, wie der photostationäre Zustand (PSS) eines E/Z‐Arylazopyrazol‐Photoschalters mit Hilfe der eingestrahlten Wellenlänge über ein breites Farbspektrum eingestellt werden kann, um die photodynamischen Eigenschaften von Hydrogelen auf der Grundlage von multivalenten, photoschaltbaren Wechselwirkungen zu beeinflussen. Wir präsentieren, dass sich diese Hydrogele an den wellenlängenabhängigen PSS und an die Anzahl der Arylazopyrazol‐Einheiten durch programmierbare Beziehungen anpassen. Unser Materialdesign ermöglicht daher die einfache Einstellung der mechanischen Eigenschaften ohne eine zeitaufwändige Synthese. Das Konzept geht über das klassische Schalten zwischen Zustand A und B hinaus und zeigt Wege für eine wellenlängenabhängige Adaption der Hydrogeleigenschaften auf, die für Weiterentwicklungen in der Zellkultivierung oder in der Soft‐Robotik nützlich sein werden.
Metallic Barium: A Versatile and Efficient Hydrogenation Catalyst
Authors: Stegner Philipp , Färber Christian , Zenneck Ulrich , Knüpfer Christian , Eyselein Jonathan , Wiesinger Michael , Harder Sjoerd 
Published: November 2020

AbstractBa metal was activated by evaporation and cocondensation with heptane. This black powder is a highly active hydrogenation catalyst for the reduction of a variety of unactivated (non‐conjugated) mono‐, di‐ and tri‐substituted alkenes, tetraphenylethylene, benzene, a number of polycyclic aromatic hydrocarbons, aldimines, ketimines and various pyridines. The performance of metallic Ba in hydrogenation catalysis tops that of the hitherto most active molecular group 2 metal catalysts. Depending on the substrate, two different catalytic cycles are proposed. A: a classical metal hydride cycle and B: the Ba metal cycle. The latter is proposed for substrates that are easily reduced by Ba0, that is, conjugated alkenes, alkynes, annulated rings, imines and pyridines. In addition, a mechanism in which Ba0 and BaH2 are both essential is discussed. DFT calculations on benzene hydrogenation with a simple model system (Ba/BaH2) confirm that the presence of metallic Ba has an accelerating effect.
Metabolic Glycoengineering with Azide‐ and Alkene‐Modified Hexosamines: Quantification of Sialic Acid Levels
Authors: Dold Jeremias E. G. A. , Wittmann Valentin 
Published: November 2020

AbstractMetabolic glycoengineering (MGE) is an established method to incorporate chemical reporter groups into cellular glycans for subsequent bioorthogonal labeling. The method has found broad application for the visualization and isolation of glycans allowing their biological roles to be probed. Furthermore, targeting of drugs to cancer cells that present high concentrations of sialic acids on their surface is an attractive approach. We report the application of a labeling reaction using 1,2‐diamino‐4,5‐methylenedioxybenzene for the quantification of sialic acid derivates after MGE with various azide‐ and alkene‐modified ManNAc, GlcNAc, and GalNAc derivatives. We followed the time course of sialic acid production and were able to detect sialic acids modified with the chemical reporter group – not only after addition of ManNAc derivatives to the cell culture. A cyclopropane‐modified ManNAc derivative, being a model for the corresponding cyclopropene analog, which undergoes fast inverse‐electron‐demand Diels‐Alder reactions with 1,2,4,5‐tetrazines, resulted in the highest incorporation efficiency. Furthermore, we investigated whether feeding the cells with natural and unnatural ManNAc derivative results in increased levels of sialic acids and found that this is strongly dependent on the investigated cell type and cell fraction. For HEK 293T cells, a strong increase in free sialic acids in the cell interior was found, whereas cell‐surface sialic acid levels are only moderately increased.
The Influence of Weakly Coordinating Cations on the O−H⋅⋅⋅O− Hydrogen Bond of Silanol‐Silanolate Anions
Authors: Weitkamp Robin F. , Neumann Beate , Stammler Hans‐Georg , Hoge Berthold 
Published: November 2020

AbstractThe reaction of a saline phosphazenium hydroxide hydrate with siloxanes led to a novel kind of silanol‐silanolate anions. The weakly coordinating behavior of the cation renders the formation of silanol‐silanolate hydrogen bonds possible, which otherwise suffer from detrimental silanolate–oxygen cation interactions. We investigated the influence of various weakly coordinating cations on silanol‐silanolate motifs, particularly with regard to different cation sizes. While large cations favor the formation of intramolecular hydrogen bonds resulting in cyclic structures, the less bulky tetramethyl ammonium cation encourages the formation of polyanionic silanol‐silanolate chains in the solid state.
Recent Advances in the Discovery of Multitargeted Tyrosine Kinase Inhibitors as Anticancer Agents
Authors: Guo Ting , Ma Shutao 
Published: November 2020

AbstractThe treatment of cancer has been one of the most significant challenges for the medical field. Further research on the signal transduction pathway of tumor cells is driving the rapid development of antitumor agents targeting tyrosine kinases. However, most of the currently approved tyrosine kinase inhibitors based on the “single target/single drug” design are becoming less and less effective in the treatment of complex, heterogeneous, and multigenic cancers; this also results in resistance to chemotherapy. In contrast, multitargeted tyrosine kinase inhibitors (MT‐TKIs) can effectively block multiple pathways of intracellular signal transduction. Therefore, they have therapeutic advantages over single‐targeted inhibitors and have become a hotspot in antitumor drug research in recent years. This minireview summarizes recent advances in the discovery of MT‐TKIs based on their chemical structures. In particular, we describe the kinase inhibitory and antitumor activity of promising compounds, as well as their structure – activity relationships (SARs).
The door to Dor: Tracing unseen anthropogenic impact in an ancient port
Authors: Lazar Michael , Basson Uri , Himmelstein Ashley G. , Levy Thomas E. , Arkin Shalev Ehud , Yasur‐Landau Assaf 
Published: November 2020

AbstractAn on‐land frequency domain electromagnetic geophysical survey was conducted across a tombolo delimiting the southern bay of Tel Dor (northern Israel) to the south. It was accompanied by a marine archaeological survey adjacent to its northern edge. Results indicate a deep channel connecting the bay and the Tantura Lagoon to the south. At its northern exit, an NW–SE trending square anomaly is visible in the geophysical data, buried underneath centuries of sand accumulation. It is parallel and similar in shape and scale to a Hellenistic feature observed in satellite data and excavated during the underwater archaeological survey. It seems that during the beginning/Middle Bronze Age, a natural or manmade channel was utilized as an entrance to the bay. As sea levels rose and sand began to accumulate, the channel was periodically filled in and would have needed to have been cleared. Eventually, it became too expensive or inconvenient to maintain, probably during the Byzantine period. The southern anchorage was abandoned for more favorable conditions to the north of the Tel. The sequence of events shows how ancient builders first utilized a natural channel, maintained it as sea levels rose, and abandoned it when it became too problematic to maintain.
Consuming local: The new obsidian source of Ideloo (Northwestern Iran) and first evidence of use by neighbouring prehistoric communities
Authors: Orange Marie , Abedi Akbar , Le Bourdonnec François‐Xavier , Vosough Bahram , Ebrahimi Ghader , Razani Mehdi , Marro Catherine 
Published: November 2020

AbstractThis paper reports the results of a recent geological and archaeological survey conducted in the Sarab district (Sabalan area) in Northwestern Iran. This survey aimed to identify potential obsidian outcrops in the region and to investigate archaeological sites in the vicinity to assess their obsidian exploitation patterns. We located a new obsidian source, Ideloo, and surveyed the previously known archaeological sites of Tepe Qalehjoogh, Kultepe Asbfrooshan, Tepe Emam Chay and Qaleh Tepe Abarghan. Here, we describe the methods and results of our surveys, along with the geochemical characterisation, using portable XRF and LA‐ICP‐MS, of both the new outcrop and the obsidian artefacts found on the sites. Our analyses have revealed the consumption of Ideloo obsidian on three of the four sites surveyed, confirming its exploitation by local communities. While validating previous assumptions regarding the existence of potential obsidian sources in Northwestern Iran, our study also highlights the consumption of raw materials originating from the Caucasus or Eastern Anatolia in complement to local resources. However, the diffusion of the Ideloo obsidian seems so far restricted to a small area, which suggests more complex consumption and trade patterns than previously expected.
Investigation of Synthetic Relaxometry and Diffusion Measures in the Differentiation of Benign and Malignant Breast Lesions as Compared to BI‐RADS
Authors: Gao Weibo , Zhang Shuqun , Guo Jinxia , Wei Xiaocheng , Li Xiaohui , Diao Yan , Huang Wei , Yao Yue , Shang Ali , Zhang Yanyan , Yang Quanxin , Chen Xin 
Published: November 2020

BackgroundBreast cancer is the most common malignant tumor in women and a quantitative contrast‐free method is highly desirable for its diagnosis.PurposeTo investigate the performance of quantitative MRI in differentiating malignant from benign breast lesions and to compare with the Breast Imaging Reporting and Data System (BI‐RADS).Study TypeRetrospective.SubjectsEighty patients (56 with malignant lesions and 24 with benign lesions).Field Strength/SequenceDiffusion‐weighted imaging (DWI) with a single‐shot echo planar sequence and synthetic MRI with magnetic resonance image compilation (MAGiC) were performed at 3T.AssessmentT1 relaxation time (T1), T2 relaxation time (T2), and proton density (PD) from synthetic MRI and apparent diffusion coefficient (ADC) from DWI were analyzed by two radiologists (Reader A, Reader B). Univariable and multivariable models were developed to optimize differentiation between malignant and benign lesions and their performances compared to BI‐RADS.Statistical TestsThe diagnostic performance was evaluated using multivariate logistic regression analysis and area under the receiver operating characteristic (ROC) curves (AUC).ResultsT2, PD, and ADC values for malignant lesions were significantly lower than those in benign breast lesions for both radiologists (all P < 0.05). The combined T2, PD, and ADC model had the best performance for differentiating malignant and benign lesions with AUC, sensitivity, specificity, positive predictive value, and negative predictive values of 0.904, 94.6%, 87.5%, 94.6%, and 87.5%, respectively. The corresponding results for BI‐RADS were no AUC, 94.6%, 75.0%, 89.8%, and 85.7%, respectively.Data ConclusionThe approach that combined synthetic MRI and DWI outperformed BI‐RADS in the differential diagnosis of malignant and benign breast lesions and was achieved without contrast agents. This approach may serve as an alternative and effective strategy for the improvement of breast lesion differentiation.Level of Evidence3.Technical Efficacy Stage3.
Copper–Calcium Poly(Acrylic Acid) Composite Hydrogels as Studied by Electron Paramagnetic Resonance (EPR) Spectroscopy
Authors: H. Haeri Haleh , Jerschabek Vanessa , Sadeghi Arash , Hinderberger Dariush 
Published: November 2020

AbstractIncorporating metal ions into synthetic polymer hydrogels results in toughening of these hydrogels. Herein, it is demonstrated that addition of small volumes of a 0.1maq. solution of Cu2+‐salts to poly(acrylic acid)‐based hydrogels (physically cross‐linked by Ca2+) increases their mechanical/rheological properties by several order of magnitude. Continuous wave (CW) and pulsed electron paramagnetic resonance (EPR) spectroscopic techniques reveal that the origin of the observed boost in mechanical properties is due to parts of the hydrogel network that interact with and through hydrated copper ions. With EPR spectroscopy, it is found that these complexes mainly have a sixfold (octahedral) H2O‐coordination shell. Hence, in copper‐containing hydrogels, in addition to direct ionic and dipolar (H‐bonding) interactions between calcium and carboxylic anions of the side chains of polymer, a second interaction arises from the noncovalent, likely electrostatic interactions of the copper hexaaqua complex and PAA carboxylic acids that are screened through the lower charge density in the hydrated complexes. Also, short‐ranged hydrogen‐bonded networks of Cu2+with aqueous solvent molecules inside the water‐filled regions of the polymeric hydrogel may play a pivotal role. The synergy of these interactions explains the improved elastic properties of copper containing hydrogels.
Accuracy of Smartphone Video for Contactless Measurement of Hand Tremor Frequency
Authors: Williams Stefan , Fang Hui , Relton Samuel D. , Wong David C. , Alam Taimour , Alty Jane E. 
Published: November 2020

ABSTRACTBackgroundComputer vision can measure movement from video without the time and access limitations of hospital accelerometry/electromyography or the requirement to hold or strap a smartphone accelerometer.ObjectiveTo compare computer vision measurement of hand tremor frequency from smartphone video with a gold standard measure accelerometer.MethodsA total of 37 smartphone videos of hands, at rest and in posture, were recorded from 15 participants with tremor diagnoses (9 Parkinson's disease, 5 essential tremor, 1 functional tremor). Video pixel movement was measured using the computing technique of optical flow, with contemporaneous accelerometer recording. Fast Fourier transform and Bland‐Altman analysis were applied. Tremor amplitude was scored by 2 clinicians.ResultsBland‐Altman analysis of dominant tremor frequency from smartphone video compared with accelerometer showed excellent agreement: 95% limits of agreement −0.38 Hz to +0.35 Hz. In 36 of 37 videos (97%), there was <0.5 Hz difference between computer vision and accelerometer measurement. There was no significant correlation between the level of agreement and tremor amplitude.ConclusionThe study suggests a potential new, contactless point‐and‐press measure of tremor frequency within standard clinical settings, research studies, or telemedicine.
Rhinovirus bronchiolitis, maternal asthma, and the development of asthma and lung function impairments
Authors: Da Silva Sena Carla R. , Morten Matthew , Meredith Joseph , Kepreotes Elizabeth , E. Murphy Vanessa , G. Gibson Peter , D. Robinson Paul , D. Sly Peter , Whitehead Bruce , Karmaus Wilfried , Collison Adam , Mattes Joerg 
Published: November 2020

AbstractBackgroundChildren with a history of rhinovirus (RV) positive bronchiolitis have a high risk of developing subsequent asthma. Maternal asthma might also increase this risk. The aim of this study was to investigate the combined effects of hospitalization for RV positive bronchiolitis in infancy and a history of maternal asthma on the development of asthma at preschool age.MethodsThis is a prospective cohort study of 139 preschool‐aged children, with a history of hospital admission for bronchiolitis in infancy, followed‐up to ascertain asthma and asthma‐like symptoms, skin prick allergy test positivity, and lung function measured pre‐ and post‐bronchodilator using impulse oscillometry.ResultsChildren with a past hospitalization for RV positive bronchiolitis (42.4% of all) and a history of maternal asthma (36.7% of all) had the greatest prevalence and risk ratio (RR) for doctor‐diagnosed asthma (prevalence 81.8% and RR 2.10, 95% confidence interval [CI] 1.37–3.19, p = .001), use of inhaled corticosteroids (68.2% and RR 2.17, 95% CI 1.19–3.99, p = .001) and short‐acting β‐agonists in the last 12 months (95.2% and RR 1.49, 95% CI 1.17–1.89, p = .001), as compared to those with RV negative bronchiolitis and no maternal asthma history. More children in this group had an abnormal airway resistance (33.3% and adjusted risk ratio [aRR] 3.11, 95% CI 1.03–9.47, p = .045) and reactance (27.8% and aRR 2.11, 95% CI 1.06–4.26, p = .035) at 5 Hz, as compared to those with RV negative bronchiolitis and no maternal asthma history.ConclusionHospitalization for RV positive bronchiolitis in early life combined with a history of maternal asthma identifies a subgroup of children with a high asthma burden while participants with only one of the two risk factors had intermediate risk for asthma.