bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calcium scoring: a personalized probability assessment predicts the need for additional or alternative testing to coronary CT angiography
Authors: Simon Judit , Száraz Lili , Szilveszter Bálint , Panajotu Alexisz , Jermendy Ádám , Bartykowszki Andrea , Boussoussou Melinda , Vattay Borbála , Drobni Zsófia Dóra , Merkely Béla , Maurovich-Horvat Pál , Kolossváry Márton 
Published: May 2020

Abstract
Objective
To assess whether anthropometrics, clinical risk factors, and coronary artery calcium score (CACS) can predict the need of further testing after coronary CT angiography (CTA) due to non-diagnostic image quality and/or the presence of significant stenosis.

Methods
Consecutive patients who underwent coronary CTA due to suspected coronary artery disease (CAD) were included in our retrospective analysis. We used multivariate logistic regression and receiver operating characteristics analysis containing anthropometric factors: body mass index, heart rate, and rhythm irregularity (model 1); and parameters used for pre-test likelihood estimation: age, sex, and type of angina (model 2); and also added total calcium score (model 3) to predict downstream testing.

Results
We analyzed 4120 (45.7% female, 57.9 ± 12.1 years) patients. Model 3 significantly outperformed models 1 and 2 (area under the curve, 0.84 [95% CI 0.83–0.86] vs. 0.56 [95% CI 0.54–0.58] and 0.72 [95% CI 0.70–0.74], p < 0.001). For patients with sinus rhythm of 50 bpm, in case of non-specific angina, CACS above 435, 756, and 944; in atypical angina CACS above 381, 702, and 890; and in typical angina CACS above 316, 636, and 824 correspond to 50%, 80%, and 90% probability of further testing, respectively. However, higher heart rates and arrhythmias significantly decrease these cutoffs (p < 0.001).

Conclusion
CACS significantly increases the ability to identify patients in whom deferral from coronary CTA may be advised as CTA does not lead to a final decision regarding CAD management. Our results provide individualized cutoff values for given probabilities of the need of additional testing, which may facilitate personalized decision-making to perform or defer coronary CTA.

Key Points
• Anthropometric parameters on their own are insufficient predictors of downstream testing. Adding parameters of the Diamond and Forrester pre-test likelihood test significantly increases the power of prediction.
• Total CACS is the most important independent predictor to identify patients in whom coronary CTA may not be recommended as CTA does not lead to a final decision regarding CAD management.
• We determined specific CACS cutoff values based on the probability of downstream testing by angina-, arrhythmia-, and heart rate–based groups of patients to help individualize patient management.
Onco-Cardiology: Consensus Paper of the German Cardiac Society, the German Society for Pediatric Cardiology and Congenital Heart Defects and the German Society for Hematology and Medical Oncology
Authors:   Committee for Clinical Cardiovascular Medicine of the German Cardiac Society, Rassaf Tienush , Totzeck Matthias , Backs Johannes , Bokemeyer Carsten , Hallek Michael , Hilfiker-Kleiner Denise , Hochhaus Andreas , Lüftner Diana , Müller Oliver J. , Neudorf Ulrich , Pfister Roman , von Haehling Stephan , Lehmann Lorenz H. , Bauersachs Johann 
Published: May 2020

AbstractThe acute and long-lasting side effects of modern multimodal tumour therapy significantly impair quality of life and survival of patients afflicted with malignancies. The key components of this therapy include radiotherapy, conventional chemotherapy, immunotherapy and targeted therapies. In addition to established tumour therapy strategies, up to 30 new therapies are approved each year with only incompletely characterised side effects. This consensus paper discusses the risk factors that contribute to the development of a potentially adverse reaction to tumour therapy and, in addition, defines specific side effect profiles for different treatment groups. The focus is on novel therapeutics and recommendations for the surveillance and treatment of specific patient groups.
Three-year audiological outcomes of the latest generation middle ear transducer (MET) implant
Authors: Skarżyński Henryk , Dziendziel Beata , Włodarczyk Elżbieta , Skarżyński Piotr H. 
Published: May 2020

Abstract
Purpose
To evaluate the long-term audiological outcomes and safety of the latest generation of middle ear transducer (MET) among a group of Polish patients.

Methods
Ten patients aged 48–72 years with bilateral sensorineural hearing loss (n = 8) and mixed hearing loss (n = 2) were included in this study. Pure tone audiometry, sound thresholds, word recognition scores in quiet and speech reception thresholds in noise were assessed. Medical and technical complication information was gathered.

Results
All the patients underwent unilateral implantation with the latest generation Cochlear MET between 2014 and 2016. Mean length of follow-up was 3.7 years. Compared to the unaided condition, the implant provided significant functional gain (mean M = 26.1 dB) at 12 months follow-up. Compared to before surgery, average word recognition in quiet at 65 dB and at 80 dB SPL, as well as speech reception threshold in noise, were significantly better at 12 months. However, postoperative air conduction thresholds 6 months after implantation worsened by 10.3 dB (standard deviation SD = 5.8 dB). Postoperatively, three patients had skin problems around the processor, and one of them completely resigned from using the device 5 months after activation. Technical failures occurred in 4 cases. There were 9 out of 10 patients who still used the MET, but only 5 of them used the processor regularly (every day).

Conclusion
Despite changes in the transducer implemented by the manufacturer, we observed a significant number of adverse events in users of the latest generation of MET.
Modellierung vergangener und zukünftiger Abflüsse und Sedimentfrachten mit freier Software – Einblicke am Beispiel des Schöttlbach (Niedere Tauern)
Authors: Peßenteiner Stefanie , Gegenleithner Sebastian , Kamp Nicole , Krenn Paul 
Published: May 2020

ZusammenfassungRezent häufigere Hochwasserereignisse und die besondere Vulnerabilität des Alpenraums gegenüber dem Klimawandel erhöhen die gesellschaftliche und politische Nachfrage nach robusten Informationen über mögliche zukünftige Entwicklungen. Ergebnisse numerischer Modellierungen in Verbindung mit Expertenmeinungen stellen ein wichtiges Instrument zur Abschätzung zukünftiger Veränderungen dar und ermöglichen die Untersuchung von Gebieten, in denen es nur wenige oder gar keine Sediment- bzw. Abflussmessungen gibt. Die Verwendung von quelloffenen (Open Source) und frei verfügbaren Modellen trägt dabei wesentlich zu Transparenz und wissenschaftlicher Nachvollziehbarkeit bei. Im vorliegenden Beitrag möchten wir eine Modellkette aus frei verfügbaren bzw. Open-Source-Modellen zur Simulation von Abflüssen und Sedimentfrachten am Beispiel des Schöttlbachs (Niedere Tauern) vorstellen und Einblicke in erste Ergebnisse geben.
Comparison of thermally and chemically reduced graphene oxides by thermal analysis and Raman spectroscopy
Authors: Farah Shereen , Farkas Attila , Madarász János , László Krisztina 
Published: May 2020

AbstractGraphene oxide (GO) is not only an intermediate in top-down graphene preparation, but it is also acknowledged for its convenient application when the hydrophobicity of graphene is a drawback. Its preparation through the wet exfoliation of graphite inevitably leads to a product lacking several of the outstanding features of graphene. The destroyed graphene structure can be at least partially reconstructed by thermal and/or wet chemical reduction. Thermally reduced graphene oxide (TRGO) was obtained by mild heat treatment (300 °C) in argon, while chemically reduced graphene oxide (CRGO) was prepared by using a green reagent, ascorbic acid (AA). The parent GO and the two GO derivatives were compared by thermogravimetric analysis coupled with mass spectroscopy and Raman spectroscopy. Both reductive treatments resulted in enhanced thermal stability and higher C/O ratio. Although the chemical reduction with AA was more efficient in the elimination of the O functionalities, it also resulted in significant fragmentation of the graphene-like platelets.
Detection of pharmaceuticals in wastewater effluents—a comparison of the performance of Chemcatcher® and polar organic compound integrative sampler
Authors: Gravell Anthony , Fones Gary R. , Greenwood Richard , Mills Graham A. 
Published: May 2020

AbstractChemcatcher® and POCIS passive sampling devices are widely used for monitoring polar organic pollutants in water. Chemcatcher® uses a bound Horizon Atlantic™ HLB-L sorbent disk as receiving phase, whilst the POCIS uses the same material in the form of loose powder. Both devices (n = 3) were deployed for 21 days in the final effluent at three wastewater treatment plants in South Wales, UK. Following deployment, sampler extracts were analysed using liquid chromatography time-of-flight mass spectrometry. Compounds were identified using an in-house database of pharmaceuticals using a metabolomics workflow. Sixty-eight compounds were identified in all samplers. For the POCIS, substantial losses of sorbent (11–51%) were found during deployment and subsequent laboratory analysis, necessitating the use of a recovery factor. Percentage relative standard deviations varied (with 10 compounds exceeding 30% in both samplers) between individual compounds and between samplers deployed at the three sites. The relative performance of the two devices was evaluated using the mass of analyte sequestered, measured as an integrated peak area. The ratio of the uptake of the pharmaceuticals for the POCIS versus Chemcatcher® was lower (1.84x) than would be expected on the basis of the ratio of active sampling areas (3.01x) of the two devices. The lower than predicted uptake may be attributable to the loose sorbent material moving inside the POCIS when deployed in the field in the vertical plane. In order to overcome this, it is recommended to deploy the POCIS horizontally inside the deployment cage.
New Criteria for Lupus
Authors: Aringer Martin , Leuchten Nicolai , Johnson Sindhu R. 
Published: May 2020

Abstract
Purpose of the Review
Classification criteria define the patient population for clinical trials and translational studies, but also influence current understanding of the disease. This review attempts to delineate the development from the American College of Rheumatology (ACR) 1982 to the European League Against Rheumatism (EULAR)/ACR 2019 classification criteria for systemic lupus erythematosus (SLE).

Recent Findings
The new EULAR/ACR classification criteria use antinuclear antibodies (ANA) as an entry criterion. (Non-infectious) fever is the one new criterion. All criteria items now have individual weights (from 2 to 10) and are structured in domains, within which only the highest item is counted. There is one common attribution rule, counting criteria only if there is no more likely alternative explanation. Ten points are sufficient for classification. The new criteria have reached a sensitivity of 96.1% and a specificity of 93.4%.

Summary
The new EULAR/ACR 2019 classification criteria for SLE build on the previous criteria sets, adding fever only as a new criteria item. The new structure is reflective of the current diagnostic approach and has led to improved statistical performance.
Standard hypothyroid treatment did not restore proper metabolic response to carbohydrate
Authors: Kozacz Agnieszka , Assis Gilmara Gomes de , Sanocka Urszula , Ziemba Andrzej Wojciech 
Published: May 2020

Abstract
Purpose
Hypothyroidism is associated with a lower metabolic rate, impaired glucose tolerance, and increased responsiveness of sympathetic nervous system to glucose ingestion. The Levothyroxine (LT4) monotherapy is the standard treatment for hypothyroidism; however to what extent this treatment restores the patients’ metabolism has not been verified. The aim of this study was to test the hypothesis that standard LT4 therapy may not restore proper metabolic response to carbohydrate ingestion.

Methods
Energy expenditure, glucose tolerance, and catecholamine response to glucose ingestion were compared in 18 subjects with pharmacologically compensated hypothyroidism (PCH) and controls, at baseline and during oral glucose tolerance test conditions.

Results
Metabolic rate was significantly lower in PCH (P < 0.0001). Glucose tolerance was decreased in this group with no differences in insulin resistance indicators between both groups. Adrenergic activity (P < 0.05) as well as adrenergic reaction to glucose ingestion (P < 0.001) were stronger in PCH.

Conclusions
Standard treatment for hypothyroidism does not restore the normal metabolic reaction to carbohydrate which is observed in healthy people.
The Effect of Chronic Mild Stress and Venlafaxine on the Expression and Methylation Levels of Genes Involved in the Tryptophan Catabolites Pathway in the Blood and Brain Structures of Rats
Authors: Wigner Paulina , Synowiec Ewelina , Jóźwiak Paweł , Czarny Piotr , Bijak Michał , Białek Katarzyna , Szemraj Janusz , Gruca Piotr , Papp Mariusz , Śliwiński Tomasz 
Published: May 2020

AbstractA growing body of evidence suggests that depression may be associated with impairment of the tryptophan catabolites (TRYCATs) pathway. The present study investigated the effects of the chronic administration of venlafaxine on the expression and methylation status of Katl, Tph1/2, Ido1, Kmo and Kynu in the brain and blood of rats exposed to the CMS model of depression. The rats were subjected to the CMS procedure for 2 or 7 weeks and administered venlafaxine (10 mg/kg/day, IP) for 5 weeks. mRNA and protein expression and the methylation status of gene promoters in PBMCs and six brain structures were evaluated and analysed using the TaqMan Gene Expression Assay and Western blotting, and methylation-sensitive high-resolution melting (MS-HRM), respectively. We found that the CMS procedure increased KatI expression in the midbrain and KatII expression in the midbrain and the amygdala, while venlafaxine administration decreased KatII expression in the hypothalamus and the cerebral cortex. The methylation status of the Tph1 and Kmo promoters in peripheral blood mononuclear cells (PBMCs) was significantly increased in the stressed group after antidepressant therapy. The protein levels of Tph1 and Ido1 were decreased following venlafaxine administration. Our results confirmed that CMS and venlafaxine modulate the expression levels and methylation status of genes involved in the TRYCATs pathway.
Long-Term Venovenous Connection for Extracorporeal Carbon Dioxide Removal (ECCO2R)–Numerical Investigation of the Connection to the Common Iliac Veins
Authors: Steuer N. B. , Hugenroth K. , Beck T. , Spillner J. , Kopp R. , Reinartz S. , Schmitz-Rode T. , Steinseifer U. , Wagner G. , Arens J. 
Published: May 2020

Abstract
Purpose
Currently used cannulae for extracorporeal carbon dioxide removal (ECCO2R) are associated with complications such as thrombosis and distal limb ischemia, especially for long-term use. We hypothesize that the risk of these complications is reducible by attaching hemodynamically optimized grafts to the patient’s vessels. In this study, as a first step towards a long-term stable ECCO2R connection, we investigated the feasibility of a venovenous connection to the common iliac veins. To ensure its applicability, the drainage of reinfused blood (recirculation) and high wall shear stress (WSS) must be avoided.

Methods
A reference model was selected for computational fluid dynamics, on the basis of the analysis of imaging data. Initially, a sensitivity analysis regarding recirculation was conducted using as variables: blood flow, the distance of drainage and return to the iliocaval junction, as well as the diameter and position of the grafts. Subsequently, the connection was optimized regarding recirculation and the WSS was evaluated. We validated the simulations in a silicone model traversed by dyed fluid.

Results
The simulations were in good agreement with the validation measurements (mean deviation 1.64%). The recirculation ranged from 32.1 to 0%. The maximum WSS did not exceed 5.57 Pa. The position and diameter of the return graft show the highest influence on recirculation. A correlation was ascertained between recirculation and WSS. Overall, an inflow jet directed at a vessel wall entails not only high WSS, but also a flow separation and thereby an increased recirculation. Therefore, return grafts aligned to the vena cava are crucial.

Conclusion
In conclusion, a connection without recirculation could be feasible and therefore provides a promising option for a long-term ECCO2R connection.
Een onbekende procedure: double-barreled wet colostomy
Authors: Yildirim Hilin , Tanis Pieter J. , de Reijke Theo M. , Beerlage Harrie P. , Hompes Roel , Oddens Jorg R. 
Published: May 2020

SamenvattingEen 62-jarige vrouw onderging een double barreled wet colostomy (DBWC) na een bekkenexenteratie. De DBWC is een relatief onbekende ingreep, waarbij een colostoma wordt aangelegd met twee openingen, waardoor urine en ontlasting via gescheiden compartimenten naar buiten worden geleid. Het doel van dit artikel is de DBWC te vergelijken met een gescheiden urostoma en colostoma aan de hand van een casus en een review van de beschikbare literatuur. Er werden drie retrospectieve studies gevonden die een DWBC vergeleken met een gescheiden uro- en colostoma, met in totaal 267 patiënten. Daaruit bleek geen verhoogde mortaliteit en morbiditeit bij een DBWC ten opzichte van een gescheiden urinestoma en colostoma. De conclusie luidt dat een DBWC kan worden overwogen na een bekkenexenteratie.
Synanthropic spider fauna of the Carpathian Basin in the last three decades
Authors: Szinetár Csaba , Kovács Gábor , Urák István , Gajdoš Peter 
Published: May 2020

AbstractThis paper reviews the scientific literature published on synanthropic spiders in three Carpathian Basin countries—Hungary, Slovakia and Romania. A total number of 204 spider species have been reported from human constructions. Most of the 204 spider species (165 species) found in buildings were only occasional visitors, so-called asynanthropic species with typically low abundance. On average, eusynanthropic (23 species) and hemisynanthropic (16 species) species accounted for 80% of the specimen number. We have discovered that the number of hemisynanthropic faunal elements have remained unchanged in the past three decades. At the same time 14 new eusynanthropic species have been observed in the region, roughly one new species in every 2 years. Some of them have been introduced from the tropics, but some species originates from southern Europe, which may be related to climate change. This hypothesis was also confirmed by the seasonal summer outdoor appearance of these eusynanthropic species. True tropical spiders could only be settled permanently in greenhouses with special climate (such as botanical gardens). We still do not have data of any synanthropic species posing a health risk in this region.
Impacts of synoptic-scale cyclones on Arctic sea-ice concentration: a systematic analysis
Authors: Schreiber Erika A. P. , Serreze Mark C. 
Published: May 2020

AbstractThe role of synoptic-scale cyclones in the trends and variability of Arctic sea ice conditions has remained uncertain. In recognition, we conduct a systematic investigation of how sea-ice concentration (SIC) changes with cyclone passage, including all individual storms that pass over any part of the region's ice pack. For all seasons, especially summer and autumn, we find a pattern of higher ice concentration after a region is influenced by a cyclone compared to when it is not, primarily due to thermodynamic effects. During warm months, cyclones appear to slow the general day-to-day decline in concentration; in cold months, cyclones augment the day-to-day increase. These relationships are changing over time, with cyclone-associated concentration changes becoming less distinct from overall changes. Cyclone effects on ice divergence are spatially variable; computed fields are noisy. In summer, these dynamic effects of cyclone passage generally decrease SIC, but are outweighed by the thermodynamic effects (e.g., reductions in air temperature, shortwave radiation). In autumn, cyclone-associated concentration changes are not as easily explained by observed cyclone conditions. Key questions remain regarding the extent to which our findings are influenced by artifacts of surface melt and weather effects on the passive microwave retrievals.
LO50: Pain free laceration repairs using intra-nasal ketamine: DosINK 2 clinical trial
Authors: Rached-Dastous S. , Trottier E. D. , Finkelstein Y. , Bailey B. , Marquis C. , Lebel D. , Desjardins M. 
Published: May 2020

Introduction: Lacerations are common in children presenting to the emergency department (ED). They are often uncooperative when sutures are needed and may require procedural sedation. Few studies have evaluated intranasal (IN) ketamine for procedural sedation in children, with doses from 3 to 9 mg/kg used mostly for dental procedures. In a previous dose escalation trial, DosINK-1, 6 mg/kg was found to be the optimal IN ketamine dose for procedural sedation for sutures in children. In this trial, we aim to further evaluate the efficacy of this dose. Methods: We conducted a multicentre single-arm clinical trial. A convenience sample of 30 uncooperative children between 1 and 12 years (10 to 30 kg) with no cardiac or kidney disease, active respiratory infection, prior administration of opioid or sedative agents received 6 mg/kg of IN ketamine using an atomizer for their laceration repair with sutures in the ED. The primary outcome was defined as the proportion (95% CI) of patients who achieved an adequate procedural sedation evaluated with the PERC/PECARN consensus criteria. Results: Thirty patients were recruited from April 2018 to November 2019 in 2 pediatric ED. The median age was 3.2 (interquartile range(IQR), 1.9 to 4.7) years-old with laceration of more than 2 cm in 20 (67%) patients and in the face in 21 (70%) cases. Sedation was effective in 18 out of 30 children 60% (95%CI, 45 to 80), was suboptimal in 6 patients (20%) with a procedure completed with minimal difficulties, and unsuccessful in the remaining 6 (20%), all without serious adverse event. Similarly, 21/30 (70%) physicians were willing to reuse IN ketamine at the same doses and 25 parents (83%) would agree to the same sedation in the future. Median time to return to baseline status was 58 min (IQR, 33 to 73). One patient desaturated during the procedure and required transitory oxygen and repositioning. After the procedure, 1 (3%) patient had headache, 1 (3%) patient had nausea, and 2 (7%) patients vomited. Conclusion: A single dose of 6 mg/kg of IN Ketamine for laceration repair with sutures in uncooperative children is safe and facilitated the procedure in 60% (95%CI, 45 to 80) of patients, was suboptimal in 20% and unsuccessful in 20% of patients. As seen with IV ketamine, an available additional dose of IN ketamine for some children if needed could potentially increase proportion of successful sedation. However, the safety and efficacy of repeated doses needs to be addressed.