bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effects of Epidural Analgesia during Labor on Maternal and Neonatal Outcomes
Authors: Huang Jin-Hua , Yu Mei , Zhang Di-Bao , Pan Jun-Ping , Zhao Xiao-Tan , Liu Quan , Yang Min 
Published: September 2020

Abstract
Background: The purpose of the study was to investigate the impact of epidural analgesia usage vs. non-epidural labor on maternal and neonatal outcomes. Methods: We included 129 parturients who had vaginal deliveries in our hospital since December 1, 2018. The women were grouped into the epidural analgesia group or the non-epidural group. In order to investigate the effect of epidural analgesia on mother and newborn outcomes, we evaluated the differences in labor duration, the Apgar score of the newborn, and the overall outcome of the mother and newborn. Results: Compared to the non-epidural group, the durations of the first and second stages of labor in the analgesia group were significantly longer. In terms of neonatal outcome, the epidural analgesia group had a higher lactate value in the umbilical artery blood and higher pCO2 of umbilical vein blood of the neonates. However, there were no significant differences in Apgar Score, umbilical blood pH, base excess, or other umbilical cord blood gas analyses (pO2, HGB, SO2, HCO3 -) between epidural analgesia and non-epidural labor groups.Conclusion: The epidural analgesia prolongs the duration of the first and second stages of labor and affects the level of lactate in umbilical artery blood and the partial pressure of carbon dioxide in umbilical vein blood. There was no significant effect on the basic characteristics of the mothers and neonates, suggesting that epidural analgesia delivery technology is safe, but it may have a particular short-term impact on neonatal outcomes.
Women’s Attitudes Towards Negotiating Safe Sexual Practices in Nigeria: Do Family Structure and Decision-making Autonomy Play a Role?
Authors: Imo Chukwuechefulam Kingsley , Odimegwu Clifford O. , De Wet-Billings Nicole 
Published: September 2020

Abstract
BackgroundThe risk of contracting sexually transmitted infections (STIs) is related to women’s sexual attitudes, beliefs, and power dynamics within marriages in developing countries. Despite the interventions towards improving women’s sexual health and well-being, the risk of transmission of STIs which disproportionately affect women continues to be widespread in most sub-Saharan African countries including Nigeria. The dearth of social research on the influence of family structure and decision-making autonomy on women’s attitudes towards negotiating safe sexual practices necessitated this study in Nigeria. MethodsThe study involved analyses of data from nationally representative and weighted sample size of 28,219 ever-married or cohabiting women aged 15-49 years from the 2018 Nigeria Demographic and Health Survey. Descriptive and analytical analyses were carried out, including frequency tables, Pearson’s chi-square test, and multivariate binary logistic regression model.ResultsThe overall prevalence of having strong attitudes towards negotiating safe sexual practices were 76.7% and 69.6% for a wife justified in asking the husband to use a condom if he has an STI and refusing to have sex with the husband if he had sex with other women, respectively. The analyses further showed that polygamous unions negatively influenced urban and rural women’s attitudes towards negotiating safe sexual practices with partners, for instance, the belief that a wife is justified asking the husband to use a condom if he has STI (aOR: 0.71; CI: 0.61-0.83 and aOR: 0.74; CI: 0.67-0.81, respectively). Similarly, urban and rural women whose husbands/partners made independent decisions on their healthcare were less likely to belief that a wife is justified in asking the husband to use a condom if he has STI (aOR: 0.60; CI: 0.47-0.76 and aOR: 0.80; CI: 0.67-0.97, respectively). Plausibly, women’s decision-making autonomy on issues relating to their earnings and healthcare might have constrained them to compromise their sexual relationships with partners. ConclusionThe outcomes of this study have some policy implications for both maternal and child health. Hence, the need to intensify programmes aimed at improving women’s sexual health and rights towards achieving sustainable development goals of preventing deaths of newborns, ending STIs and creating gender in Nigeria.
First Wave of COVID-19 Hospital Admissions in Denmark: A Nationwide Population-Based Cohort Study
Authors: Holler Jon Gitz , Eriksson Robert , Jensen Tomas Østergaard , Wijhe Maarten Van , Fischer Thea Kølsen , Søgaard Ole Schmeltz , Israelsen Simone Bastrup , Mohey Rajesh , Fabricius Thilde , Jøhnk Frederik , Wiese Lothar , Johnsen Stine , Søborg Christian , Nielsen Henrik , Kirk Ole , Madsen Birgitte Lindegaard , Harboe Zitta Barrella 
Published: September 2020

Abstract
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease coronavirus disease 2019 (COVID-19), is a worldwide emergency. Demographic, clinical and laboratory factors associated with mortality in Danish patients hospitalised with COVID-19 is limited.Methods: National health registries were used to identify all hospitalized patients with a COVID-19 diagnosis. We obtained demographics, Charlson Comorbidity Index (CCI), and laboratory results on admission and explored prognostic factors for death using multivariate Cox proportional hazard regression and competing risk survival analysis.Results: Among 2,431 hospitalised patients with COVID-19 between February 27th and July 8th (median age 69 years [IQR 53–80], 54.1% males), 359 (14.8%) needed admission to an intensive care unit (ICU) and 455 (18.7%) died within 30 days of follow-up. The seven-day cumulative incidence of ICU admission was lower for females (7.9%) than for males (16.7%), (p < 0.001). Age, high CCI, elevated C-reactive protein (CRP), ferritin, D-dimer, lactate dehydrogenase (LDH), urea, creatinine, lymphopenia, neutrophilia, and thrombocytopenia within 24-hours of admission were independently associated with death within the first week in the multivariate analysis. Conditional upon surviving the first week, male sex, age, high CCI, elevated CRP, LDH, creatinine, urea and neutrophil count were associated with death within 30 days. Males presented with more pronounced laboratory abnormalities on admission. Conclusions: Advanced age, male sex, comorbidity, higher levels of systemic inflammation and cell-turnover were prognostic factors for mortality. Age was the strongest predictor for death, moderate to high level of comorbidity were associated with a nearly two-fold increase in mortality. Mortality was significantly higher for males after surviving the first week.
Anxiety, Depression and Functional impairment during the COVID-19 Pandemic among Health Care Workers: A Cross Sectional Online Survey
Authors: Shrestha Rajan , Khatri Bijay , Ranjitkar Suman , Adhikari Santoshi , Poudyal Prasanta 
Published: September 2020

Abstract
BackgroundCOVID-19 is an infectious disease caused by a newly discovered, with more than 24 million cases worldwide. Geometrically increasing numbers of cases and deaths from COVID 19 in the world, both medical staff and the public have been experiencing psychological problems, which can cause disability and functional impairment of the individual. This study aimed to determine the burden of stress anxiety and depression among health care workers.MethodologyA hospital-based cross-sectional study was carried out among all the employees of Hospital for Children Eye ENT and Rehabilitation Services Bhaktapur during the COVID-19 pandemic lockdown using an online questionnaire. The tools used were adopted from Hospital Anxiety and Depression scale (HADS) Nepali version and WHO Disability Assessment Schedule (WHODAS2.0).ResultsThe mean age (SD) of the participants (n=86) was 32.53 (7.92) years. Male and female participants were equal in number. The point prevalence of anxiety and depression was 25.6% and 14.0%, respectively. Females had a higher prevalence of both anxiety (39.5% vs 11.6%, p<0.01) and depression (18.6% vs 9.3%, p=0.351). Clinical and non-clinical staff both had a higher prevalence of both anxiety (31.0% and 20.5%, p=0.265) and depression (16.7% and 11.4%, p=0.478). Mean disability score (WHODAS 2.0) among all participants and participants with anxiety and depression was 19.47 (95% CI: 18.13-20.80), 21.27 (95% CI: 18.08-24.46) and 19.92 (15.28-24.56), respectively.ConclusionAnxiety and depression during COVID-19 pandemic lockdown were highly prevalent both in clinical and non-clinical employees, without causing significant functional impairment among health care workers.
Proteomics Analysis Identified Hub Genes Associated With RNAi-Induced Silencing of G1 Cyclins in MDA-MB-231 Cells
Authors: Shamsabadi Fatemeh T. , Eidgahi Mohammad Reza Akbari , Yamchi Ahad , Guarnaccia Corrado , Shahbazi Majid 
Published: September 2020

Abstract
Background: The G1 cyclins are the most potent candidates in the pathogenesis of breast cancer. This study was designed to analyze the synergistic effect of G1 cyclins silencing on the proliferation of breast cancer cells and to identify G1 cyclins-molecular targets by proteomics approach.Methods: The MDA-MB-231 cells were transfected by a dual shRNA vector targeting G1 cyclins through a bidirectional survivin promoter. Silencing efficacy and cell proliferation were evaluated by real-time PCR, Western blot, and MTS assays, respectively. The protein expression profile was evaluated by 2D gel electrophoresis and mass spectroscopy. Further, bioinformatics tools were applied to identify the molecular targets by G1 cyclins and their possible biological consequences.Results: In response to G1 cyclins silencing, the proliferation of cells exposed to the dual shRNA vector decreased significantly at 72 h post-transfection. The reduction of G1 cyclins proteins was following their mRNA expression level as well. Protein signature of cells was altered in response to the silencing of G1 cyclins, 13 up-regulated, and seven down-regulated. Network analysis of G1 cyclins-regulated proteins identified ACTB, HSP90AA1, ALB, and HSPA5 as the hub genes according to the degree method.The regulated proteins by G1 cyclins participate in cancer-related pathways such as PI3K-Akt signaling pathway and pathways in cancer (HSP90AA1; HSP90AB1; HSP9B1), HIF-1 signaling pathway (LDHA; ALDOA; PGK1), apoptosis and proteoglycans in cancer (ACTB).Conclusions: We identified the G1 cyclins-regulated proteins and their mode of action in the pathogenesis of breast cancer. Our findings suggested that G1 cyclins participate in various biological functions. Meanwhile, it offers a new perception of the interactions among G1 cyclins-regulated proteins to identify targeted treatment. It follows-up research in the field of breast cancer.
miR-1250-5p is a novel tumor suppressive intronic miRNA hypermethylated in non-Hodgkin’s lymphoma: novel targets with impact on ERK signaling and cell migration
Authors: Zhang Min Yue , Wang Lu Qian , Chim James 
Published: September 2020

Abstract
Background

miR-1250 is localised to the second intron of AATK at chromosome 17q25. As a CpG island is present at the putative promoter region of its host gene, AATK, we postulated that the intronic miR-1250-5p is a tumor suppressor miRNA co-regulated with its host gene, AATK, by promoter DNA methylation in non-Hodgkin’s lymphoma (NHL).
Methods

AATK/miR-1250 methylation was studied in healthy controls, including ten normal peripheral blood buffy coat and eleven normal tonsils, ten lymphoma cell lines, and 120 primary lymphoma samples by methylation-specific PCR (MSP). The expression of miR-1250-5p and AATK was investigated by quantitative real-time PCR. Tumor suppressor properties of miR-1250-5p were demonstrated by over-expression of precursor miR-1250-5p in lymphoma cells. The target of miR-1250-5p was verified by luciferase reporter assay.
Results

AATK/miR-1250 methylation was absent in healthy peripheral blood and tonsils, but detected in five (50%) NHL cell lines. AATK/miR-1250 methylation correlated with repression of miR-1250-5p and AATK in NHL cell lines. In completely methylated SU-DHL-6 and SUP-T1 cells, treatment with 5-AzadC led to promoter demethylation and re-expression of both miR-1250-5p and AATK. In primary lymphoma samples, AATK/miR-1250 was frequently methylated in B-cell lymphoma (n = 41, 44.09%) and T-cell lymphoma (n = 9, 33.33%) with a comparable frequency (P = 0.318). In SU-DHL-1 cells, restoration of miR-1250-5p resulted in decreased cellular proliferation by MTS assay, increased cell death by trypan blue staining and enhanced apoptosis by annexin V-PI assay. Moreover, MAPK1 and WDR1 were verified as direct targets of miR-1250-5p by luciferase assay. In 39 primary NHLs, miR-1250-5p expression was shown to be inversely correlated with each of MAPK1 (P = 0.05) and WDR1 (P = 0.031) by qRT-PCR. Finally, in SU-DHL-1 cells, overexpression of miR-1250-5p led to repression of MAPK1 and WDR1 at both transcript and protein levels, with downregulation of phospho-ERK2 by Western-blotting and inhibition of SDF-1-dependent cell migration by transwell assay.
Conclusions

miR-1250-5p is a novel tumor suppressive intronic miRNA co-regulated and silenced by promoter DNA methylation of its host gene AATK in NHL. MAPK1 and WDR1 are novel miR-1250-5p direct targets rendering inhibition of MAPK/ERK signaling and SDF-1-dependent cell migration, hence implicated in survival and dissemination of lymphoma.
Impact of Previous Abdominal Surgery on Robotic-Assisted Rectal Surgery in Patients with Rectal Cancer Undergoing Preoperative Chemoradiotherapy: A Propensity Score Matching Study
Authors: Huang Ching-Wen , Su Wei-Chih , Chang Tsung-Kun , Ma Cheng-Jen , Yin Tzu-Chieh , Tsai Hsiang-Lin , Chen Po-Jung , Chen Yen-Cheng , Li Ching-Chun , Hsieh Yi-Chien , Wang Jaw Yuan 
Published: September 2020

Abstract
Background: The application of minimally invasive surgery in patients with colorectal cancer (CRC) and a history of previous abdominal surgery (PAS) remains controversial. This retrospective study with propensity score matching (PSM) investigated the impact of PAS on robotic-assisted rectal surgery outcomes in patients with rectal cancer undergoing preoperative concurrent chemoradiotherapy (CCRT).Methods: In total, 203 patients with rectal cancer who underwent preoperative CCRT and robotic-assisted rectal surgery between May 2013 and December 2019 were enrolled. Patients were categorized into PAS and non-PAS groups based on the PAS history. The PSM caliper matching method with 1-to-3 match was used to match PAS patients with non-PAS.Results: Of the 203 enrolled patients, 35 were PAS patients 168 were non-PAS patients. After PSM, 32 PAS patients and 96 non-PAS patients were included for analysis. No significant between-group differences were noted in the perioperative outcomes, including median console time [165 min (PAS) vs 175 min (noon-PAS), P = 0.4542)] and median operation time [275 min (PAS) vs 290 min (non-PAS), P = 0.5943)] after PSM. Postoperative recovery and overall complication rates were also similar (all P > 0.05). Moreover, the between-group differences in pathological or short-term oncological outcomes were also nonsignificant (all P > 0.05). No 30-day postoperative deaths were observed in either group.Conclusion: The current results indicate that robotic-assisted surgery is safe and feasible for PAS patients with rectal cancer undergoing preoperative CCRT. However, future prospective randomized clinical trials are required to verify these findings.
One Possible Cause for the Frequent Occurrence and Nonunion of Type II Odontoid Fracture&nbsp;
Authors: Dong Weixin , Hu Yong , Zhong Jian-bin , Yuan Zhen-shan , Zhu Bing-ke , Lai Ou-jie , Sun Xiao-yang 
Published: September 2020

Abstract
Background. To analyze the underlying causes of frequent occurrence and nonunion of type II odontoid fracture.Methods. CT scans along with 3D imaging software (Mimics software) were used to measure the bone density of the axis. The axis was divided into three parts, including the odontoid of the axis (the first part), the base of the odontoid (the second part) and the body of the axis (the third part). The CT value of the axis was measured and analyzed in different axial planes from top to bottom, followed by calculation and comparison of the mean CT value of the three parts of the axis.Results. The mean CT value of the odontoid (the first part), base of the odontoid (the second part) and body of the axis (the third part) was 651.35±188.32, 318.38±98.82 and 397.45±93.59, respectively. In addition, the interval variation of CT value of different axial planes was initially decreased and further increased with the change of axial planes from top to bottom.Conclusion. The mean CT value of the base of the odontoid was significantly lower than that of the odontoid or the body of the axis. Therefore, the base of the odontoid was the transition region of shape and bone density, which may be one possible cause for the frequent occurrence and nonunion in the type II odontoid fracture in axis fracture.
Quality of Life Determinants in Professional Athletes
Authors: Nowak Paweł F. , Kuśnierz Cezary , Bajkowski Dariusz 
Published: September 2020

Abstract
BackgroundThe study attempted to answer the question whether the type of practiced sport (individual, team) is a determinant of quality of life in athletes. The study was also intended to identify quality of life determinants in karate practitioners and team sports players from among such socio-cultural variables as age, gender, marital status, financial situation, education, and types of health behaviors.MethodsThe study involved 110 Polish players of team sports and 90 martial arts practitioners. All competitors had high sporting achievements.A Paper-and-Pen Interview questionnaire was used as a standardized survey method. The Inventory of Health Behaviors by Z. Juczyński was used to evaluate respondents’ health behaviors. The Comprehensive Quality of Life Scale by R. A. Cummins was used to measure the quality of life in its objective and subjective components, covering seven domains: material well-being, health, productivity, intimacy, safety, community and emotional well-being.ResultsThe assumed research model proved to be statistically significant. However, of the many quality of life predictors only three proved to be statistically significant: proper dietary habits, positive mental attitude and athletes’ gender. It turned out that men are statistically more likely to achieve a higher quality of life than women. The type of practiced sport did not turn out to be a quality of life determinant.ConclusionsThe results of the present study shows that it is necessary to intensify activities constituting the educational framework of athletes’ training, including the activities of specialists in the area of pro-health behaviors: nutritionists, psychologists, health promoters, as it increases the chances of improving athletes’ overall quality of life.
The Effect of Multimodal Comprehensive Care Methodology Training on Oral Health Care Professionals’ Empathy for Patients With Dementia
Authors: Kobayashi Masaki , Ito Mio , Iwasa Yasuyuki , Motohashi Yoshiko , Edahiro Ayako , Shirobe Maki , Hirano Hirohiko , Gineste Yves , Honda Miwako 
Published: September 2020

Abstract
Background: The prevalence of oral diseases in people with dementia has increased, and patients with dementia have worse oral health than people without dementia. However, in the provision of oral care, these patients often exhibit care-resistant behaviours. Empathy is important for health care professionals who provide dental care for people with dementia. A study was conducted to assess whether a multimodal comprehensive care methodology training programme: HumanitudeTM is associated with an improvement in empathy for people with dementia among oral health care professionals.Methods: This research was a pre-post prospective study. A total of 45 dentists and dental hygienists participated in a 7-hour multimodal comprehensive care methodology training programme. Participants’ empathy for their patients was evaluated with the Jefferson Scale of Physician Empathy-Health Professionals Version (JSPE-HP) before the training and one month after the training (primary outcome). Each participant listed 3 patients from his or her clinical practice for whom he or she felt difficulty to provide oral care due to dementia. The oral health of the 3 care-resistant patients listed by each participant was evaluated by the Oral Health Assessment Tool (OHAT) before the training and one month after the training (secondary outcome).Results: The post-training response rate was 87% (21 dentists and 18 dental hygienists). From pre-training to post-training, the multimodal comprehensive care methodology training significantly increased the mean empathy score (from 113.97 to 122.95, P<0.05, effect size=0.9). Regardless of gender, profession and years of clinical experience, all post-training subgroup scores were higher than the pre-training subgroup scores. The tongue, natural teeth, and oral hygiene scores of patients, as assessed by the OHAT, were significantly improved compared with those before the training.Conclusions: Multimodal comprehensive care methodology training was associated with an improvement in oral health professionals’ empathy for patients with dementia and an improvement in the oral health of their patients. These findings suggest that randomized controlled trials with large sample sizes will be needed.Trial registration: UMIN Clinical Trials Registry (UMIN-CTR), UMIN000041687. Registered 4 September 2020 – Retrospectively registered, https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000047586
Efficient Photocatalytic Hydrogen Peroxide Generation Coupled with Selective Benzylamine Oxidation over Defective ZrS3 Nanobelts
Authors: Tian Zhangliu , Han Cheng , Zhao Yao , Dai Weirui , Lian Xu , Wang Yanan , Zheng Yue , Shi Yi , Pan Xuan , Huang Zhichao , Li Hexing , Chen Wei 
Published: September 2020

Abstract
Photocatalytic hydrogen peroxide (H2O2) generation represents a promising approach for artificial photosynthesis. However, the sluggish half-reaction of water oxidation significantly limits the efficiency of H2O2 generation. A substitutional reaction of oxidation with accelerated kinetics to produce value-added chemicals holds promise to tackle this challenge. Here, a benzylamine oxidation with more favorable thermodynamics is employed as the half-reaction to couple with H2O2 generation in water by using defective zirconium trisulfide (ZrS3) nanobelts as photocatalyst. The ZrS3 nanobelts with disulfide (S22-) and sulfide anion (S2-) vacancies exhibit an excellent photocatalytic performance for H2O2 generation and simultaneous oxidation of benzylamine to benzonitrile with a high selectivity of > 99%. The S22- vacancies are revealed to facilitate the separation of photogenerated charge carriers. The S2- vacancies can significantly improve the electron conduction, hole extraction, and kinetics of benzylamine oxidation. As a result, the use of defective ZrS3 nanobelts yields a high production rate of 78 and 32 µmol h-1 for H2O2 and benzonitrile, respectively, under a simulated sunlight irradiation.