bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, Purification, and Characterization of a Structured Lipid Based on Soybean Oil and Coconut Oil and Its Applications in Curcumin‐Loaded Nanoemulsions
Authors: Ji Shengyang , Wu Jin , Xu Feiran , Wu Ying , Xu Xiaoying , Gao Houbin , Ju Xingrong , Xiong Wenfei , Wang Lifeng 
Published: August 2020

AbstractSingle natural vegetable oils may have some drawbacks in terms of structure and function. Enzymatic interesterification can greatly improve the quality of natural vegetable oils. In this study, soybean oil (SO) and coconut oil (CO) are combined to synthesize structured lipids (SLs) using Lipozyme RM IM as a catalyst to modify the structure of coconut oil, which can make coconut oil have better physicochemical properties. A total of 55.73% structured lipids of total triacylglycerols are synthesized under the optimum reaction conditions. The main fatty acids of SL‐SOCO are linoleic (C18:2, 37.11%), oleic (C18:1, 21.73%), and lauric (C12:0, 14.05%). The most abundant TAG species in SL‐SOCO are (14:0‐18:1‐18:3), (12:0‐14:0‐18:3), and (14:0‐14:0‐18:3) with the relative content of 10.56%, 7.13%, and 5.52%, respectively. Compared to the crystallization curves of SOCO, SL‐SOCO showed a delayed crystallization and a decreased enthalpy. Moreover, the curcumin nanocarrier prepared by SL‐SOCO as the oil phase has good stability, encapsulation efficiency (91.12%), and improved bioavailability (54.02%). To conclude, SL‐SOCO with monounsaturated fatty acid, polyunsaturated fatty acids, and medium‐chain fatty acids has good structural composition and SL‐SOCO nanoparticles have excellent applications in drug delivery system.Practical Applications: The prepared SLs can be used as one kind of functional lipids, which has the potential to improve lipid metabolism. In addition, it can be used as an oil phase to prepare carriers for encapsulating active substances, which have good stability, improved encapsulation efficiency, and bioavailability.
Sensor application of mobile nursing integrated workstation measurement system based on SOA architecture model in nursing information management
Authors: Fu Ailan , Han Huifang 
Published: August 2020

AbstractBased on the current status of the mobile medical market, combined with the specific needs of clinical care, this article analyzes the needs and business models of mobile nursing integrated workstations in detail, and combines the user's usage habits with the SOA architecture implemented by WebService. XML, as a standard format for data exchange between heterogeneous systems, and the data exchange method of ORACLE object technology, complete the interaction of data information; and use mobile intelligent devices to achieve the first‐time data collection at the bedside, and design mobile care integration workstation.
MHD nonlinear natural convection flow of a micropolar nanofluid past a nonisothermal rotating disk
Authors: Ibrahim Wubshet , Zemedu Chaluma 
Published: August 2020

AbstractThe aim of this analysis is to examine the steady, laminar boundary layer flow of a micropolar nanofluid owing to a rotating disk in the presence of a magnetic field and thermal and solutal nonlinear convection and nonisothermal parameters. The governing joined partial differential equations are converted into nonlinear ordinary differential equations by means of available transformations. The equations are calculated using the method bvp4c from Matlab software. The convergence test has been maintained; for the number of spots greater than the appropriate mesh number of points, the precision is not influenced, but the set time is boosted. Moreover, various quantities of the main parameters on skin friction coefficients, wall couple stress coefficients, Nusselt number, Sherwood number, velocities, temperature, and concentration of nanofluid are analyzed by means of tables and graphs. The results indicate that the presence of the nonisothermal parameter boosts the radial skin friction, temperature, and Sherwood number but causes decaying concentration distributions, the azimuthal skin friction coefficient, and Nusselt number that indicate the diffusion of momentum occurs more around the surface of the rotating disk.
The failed promise of IeCT for development: Aunt Ofelia replies to her letter 20 years later
Authors: Gomez Ricardo 
Published: August 2020

AbstractThis paper reflects on the nature of social changes brought about by information and communication technologies for development (ICTD or ICT4D) over the past two decades. We respond to the 2002 Letter to Aunt Ofelia, a publication that resulted from collective workshop of ICTD practitioners in Latin America. The Letter to Aunt Ofelia, written in the form of a letter to an imaginary aunt, presented seven proposals for equitable development using ICT. In this note, we use the epistolary format again as a response from the imaginary aunt, to present 10 challenges that represent failures and setbacks of ICT working against rather than for human development. These challenges pertain to commerce, services, media, surveillance, algorithmic control, addiction, misinformation, acceleration, loneliness, and environmental degradation. These 10 issues deserve our critical attention and creative energies if we are to truly harness the power of ICT for human development with equity, prosperity, and social justice.
Versatile lysine dendrigrafts and polyethylene glycol hydrogels with inherent biological properties: in vitro cell behavior modulation and in vivo biocompatibility
Authors: Carrancá Mariana , Griveau Louise , Remoué Noëlle , Lorion Chloé , Weiss Pierre , Orea Valérie , Sigaudo‐Roussel Dominique , Faye Clément , Ferri‐Angulo Daniel , Debret Romain , Sohier Jérôme 
Published: August 2020

AbstractPoly(ethylene glycol) (PEG) hydrogels have been extensively used as scaffolds for tissue engineering applications, owing to their biocompatibility, chemical versatility, and tunable mechanical properties. However, their bio‐inert properties require them to be associated with additional functional moieties to interact with cells. To circumvent this need, we propose here to reticulate PEG molecules with poly(L‐lysine) dendrigrafts (DGL) to provide intrinsic cell functionalities to PEG‐based hydrogels. The physico‐chemical characteristics of the resulting hydrogels were studied in regard of the concentration of each component. With increasing amounts of DGL, the cross‐linking time and swelling ratio could be decreased, conversely to mechanical properties, which could be tailored from 7.7 ± 0.7 to 90 ± 28.8 kPa. Furthermore, fibroblasts adhesion, viability, and morphology on hydrogels were then assessed. While cell adhesion significantly increased with the concentration of DGL, cell viability was dependant of the ratio of DGL and PEG. Cell morphology and proliferation; however, appeared mainly related to the overall hydrogel rigidity. To allow cell infiltration and cell growth in 3D, the hydrogels were rendered porous. The biocompatibility of resulting hydrogels of different compositions and porosities was evaluated by 3 week subcutaneous implantations in mice. Hydrogels allowed an extensive cellular infiltration with a mild foreign body reaction, histological evidence of hydrogel degradation, and neovascularization.
Temporal variability of seasonal warming rates in China
Authors: Xu Chen , Hou Meiting , Yan Xiaodong , Zhang Xianliang 
Published: August 2020

AbstractCalculation of the warming rate is the key to addressing the current debate about the existence of a recent hiatus in global warming. Previous studies have calculated the warming rate based on either a long period or selected periods. We calculated the warming rate in the seasonal temperatures obtained from 2,479 weather stations across China. We identified all the trend change years and divided the period 1958–2017 into different sub‐periods based on these years. Our results showed that the warming rate is higher than 0.5°C per decade in numerous stations. The amount of seasonal warming over the past 60 years was highest in winter, followed by spring, then autumn and was lowest in summer. Northern China has shown stronger warming than southern China over the past 60 years. Our results quantified the short‐period rates and identified natural change points which allows a sound comparison across regions. As rapid warming has a strong influence on natural systems and human health, extra care should be taken in regions with a high rate of warming.
Laparoscopic staged colon‐first resection for metastatic colorectal cancer: Perioperative and midterm outcomes from a single‐center experience
Authors: Sebastián‐Tomás Juan Carlos , Domingo‐del Pozo Carlos , Gómez‐Abril Segundo Ángel , Navarro‐Martínez Sergio , Ortiz‐Tarín Inmaculada , Torres‐Sánchez Teresa , Martínez‐Blasco Amparo , Martínez‐Pérez Aleix 
Published: August 2020

AbstractIntroductionThe present study aimed to evaluate the short‐ and mid‐term outcomes of laparoscopic colon‐first staged resection for colorectal cancer (CRC) and colorectal cancer liver metastases (CRCLM).MethodsThis study included patients with metastatic CRC who underwent laparoscopic surgical staged resection for the primary tumor and CRCLM between June 2013 and December 2018. Data collection included the baseline patient's and tumor features, the perioperative and histopathologic outcomes from both surgical procedures, and the oncologic follow‐up.ResultsTwenty‐five patients were eligible for the study. Three major and 22 minor laparoscopic liver resections were performed following laparoscopic CRC surgery. Five patients required conversion to laparotomy during CRCLM resection, but no conversion was needed for the colorectal procedures. The rate of severe intraoperative complications (CLASSIC grade III‐IV) was 8% and 16% during CRC and CRCLM resection, respectively. Three patients (12%) developed major postoperative complications (Clavien‐Dindo grade > III) after both interventions, including one death due to intraoperative bleeding. During a median follow‐up of 30 months, 15 patients were diagnosed with disease recurrence. The 3‐year disease‐free survival and overall survival were 33.3% and 73.9%, respectively.ConclusionsLaparoscopic staged resection for CRC and CRCLM is safe, feasible, and offers acceptable midterm oncological outcomes in patients with metastatic colorectal cancer.
An extension of the Cayley transform method for a parameterized generalized inverse eigenvalue problem
Authors: Dalvand Zeynab , Hajarian Masoud , Roman Jose E. 
Published: August 2020

SummarySince recent studies have shown that the Cayley transform method can be an effective iterative method for solving the inverse eigenvalue problem, in this work, we consider using an extension of it for solving a type of parameterized generalized inverse eigenvalue problem and prove its locally quadratic convergence. This type of inverse eigenvalue problem, which includes multiplicative and additive inverse eigenvalue problems, appears in many applications. Also, we consider the case where the given eigenvalues are multiple. In this case, we describe a modified problem that is not overdetermined and discuss the extension of the Cayley transform method for this modified problem. Finally, to demonstrate the effectiveness of these algorithms, we present some numerical examples to show that the proposed methods are practical and efficient.
Using a participatory impact assessment framework to evaluate a community‐led mangrove and fisheries conservation approach in West Kalimantan, Indonesia
Authors: Miller Adam E. , Davenport Andrew , Chen Stephanie , Hart Caroline , Gary Demi , Fitzpatrick Ben , Muflihati  , Kartikawati  , Sudaryanti  , Sagita Novia 
Published: August 2020

Abstract

Community‐based conservation has been identified as a solution to biodiversity loss, climate change and the reduction of rural poverty. The heterogeneity in social and economic inequalities often acts as a barrier to community engagement in resource management and further inhibits the distributional equity of social and ecological outcomes.

This study presents a participatory impact assessment (PIA) framework that evaluated the outcomes of a cross‐sector community‐led conservation initiative. Community members involved in the programme identified activities and outcomes for the conservation cooperative (CC), ranking the influence of the former on the latter as well as their daily life through multiple focus group discussions (FGDs). Participants were asked to rank the impact of activities on outcomes and the scale of the outcome which was totalled to identify the most impactful programme activities and outcomes during the project period.

Community members reported improved income, health, education and the creation of a locally led natural resource management system. Members also reported improved crab harvest rates and reduced mangrove deforestation. Environmental outcomes identified by community members through the PIA were verified through a secondary spatial analysis and mud crab independent fisheries monitoring.

The results support the hypothesis that environmental non‐governmental organizations (NGOs) need to consider a multi‐dimensional view of human well‐being, and that cross‐sector integrated interventions may be effective at improving multiple outcomes.

Future steps should focus on spatial replication of the CC programme which will provide further insights by testing for differences in outcomes between villages, how those are impacted by pre‐existing social and ecological systems and comparing outcomes between control sites that did not receive interventions.

A free Plain Language Summary can be found within the Supporting Information of this article.
The association between physicians’ exercise counseling and physical activity in patients with cancer: Which roles do patients’ satisfaction and previous physical activity levels play?
Authors: Depenbusch Johanna , Haussmann Alexander , Tsiouris Angeliki , Schmidt Laura , Wiskemann Joachim , Ungar Nadine , Sieverding Monika , Steindorf Karen 
Published: August 2020

AbstractObjectivesThe purpose of this study was to examine the association between physicians’ exercise counseling and post‐diagnosis physical activity (PA) in patients with cancer by investigating the mediating role of patients’ satisfaction with exercise counseling as well as the moderating role of patients’ previous PA.MethodsThe study sample consisted of 1002 people with cancer (503 breast, 265 prostate, and 234 colorectal cancer). Participants reported their pre‐ and post‐diagnosis moderate‐to‐vigorous PA (MVPA) levels, indicated whether their physician had covered different steps of exercise counseling as defined by the 5A framework (Assess, Advise, Agree, Assist, and Arrange) and rated their satisfaction with exercise counseling. A conditional process analysis was used to determine the direct and indirect effects of counseling on post‐diagnosis MVPA through satisfaction at different levels of pre‐diagnosis MVPA.ResultsPhysicians’ exercise counseling was associated with post‐diagnosis MVPA in patients with cancer. However, the association differed by patients’ pre‐diagnosis MVPA (P = .039). While counseling was directly associated with higher post‐diagnosis MVPA for individuals with low pre‐diagnosis MVPA (CI: 0.02‐0.20, P = .014), the effect was mediated through satisfaction with exercise counseling for previously highly active individuals (Boot CI: 0.01‐0.08).ConclusionsOur findings emphasize the relevance of physicians’ exercise counseling for PA in patients with cancer. However, the results indicate that in order to effectively influence patients’ PA, it appears important to provide a comprehensive counseling that is adjusted to the patients’ exercise experiences.
Predictors of long‐term anxiety and depression in uveal melanoma survivors: A cross‐lagged five‐year analysis
Authors: Brown Stephen L. , Fisher Peter L. , Hope‐Stone Laura , Hussain Rumana N. , Heimann Heinrich , Damato Bertil , Cherry M. Gemma 
Published: August 2020

AbstractObjectiveCancer survivors commonly experience long‐term anxiety and depression. Anxiety and depression might result from problems emerging during survivorship rather than illness and treatment. This study tested three potential causal paths: (a) concerns about physical symptoms and functional problems and fear of cancer recurrence (FCR) arising during survivorshipdirectlycause anxiety and depression, (b) anindirectpath whereby FCR mediates effects of concerns about physical symptoms and functional problems on anxiety and depression, and (c) areciprocalpath whereby anxiety and depression cause concerns about physical symptoms and functional problems and FCR, which exacerbate later anxiety and depression.MethodsSample of 453 uveal melanoma survivors who completed observations 6‐, 12‐, 24‐, 36‐, 48‐ and 60‐months post‐diagnosis and did not miss two consecutive observations. Cross‐lagged analyses were conducted to predict Hospital Anxiety and Depression Scale subscale scores. Symptoms and functional problems were measured using the EORTC OPT 30 scale, and FCR operationalised by the EORTC OPT 30 worry about recurrence scale. Covariates were age, gender, treatment modality, and visual acuity of the fellow eye and chromosome‐3 status (which accurately predicts 10‐year survival), worry and anxiety or depression.ResultsAll paths received some support, although the indirect path emerged only for anxiety in females. Concerns about physical symptoms, functional problems, and FCR originated in survivorship and appeared to both influence and be influenced by anxiety and depression.ConclusionsFindings emphasise the importance of actively monitoring survivors to prevent, detect, and intervene in the development of anxiety and depression during survivorship.
Disability is associated with catastrophizing and not with pain intensity in patients with low back pain: A retrospective study
Authors: Pierobon Andrés , Raguzzi Ignacio , Soliño Santiago , Salzberg Sandra , Pierobon Gabriel , Vuoto Tomás , Vera Amor Juan Sebastián , Snaider Camila , Castro Lucia 
Published: August 2020

AbstractObjectiveLow back pain (LBP) is the leading cause of years lived with disability at a global scale. The development and chronicity of LBP are influenced by multiple factors, and among them is catastrophizing. We are unaware of the impact that catastrophizing may have on pain and disability in our population. We also lack the tools that allow us to determine in which cases catastrophizing should be assessed. The primary objective is to compare the disability and pain intensity values at baseline in low back pain patients with high and low catastrophizing. The secondary objectives are to analyse the correlation between variables and determine disability variance, and develop a prediction model to identify patients with high catastrophizing.MethodThis is a retrospective study. We included the baseline data of patients with LBP. A PCS score ≥ 23 was classified as “high catastrophizing.”ResultsA total 121 medical sheets were analysed. Patients with high catastrophizing showed greater disability, with no differences in pain intensity. The PCS value explained 20% of the variance of disability, and pain was 1%. A cut‐off point of 11 in the RMQ allowed us to identify patients with high and low catastrophizing, with an accuracy of 76.67%.ConclusionLBP patients with high catastrophizing reported greater disability than those with low catastrophizing, with no differences as to pain intensity. The PCS was the most relevant variable to explain variability in the RMQ. The RMQ allowed us to identify patients with high and low catastrophizing.
A Bayesian basket trial design accounting for uncertainties of homogeneity and heterogeneity of treatment effect among subpopulations
Authors: Asano Junichi , Hirakawa Akihiro 
Published: August 2020

SummaryBasket trials are a recent and innovative approach in oncological clinical trial design. A basket trial is a type of clinical trial for which eligibility is based on the presence of a specific genomic alteration, irrespective of cancer type. Additionally, basket trials are often used to evaluate the response rate of an investigational therapy across several types of cancer. Recently developed statistical methods for evaluating the response rate in basket trials can be generally categorized into two groups: (a) those that account for the degrees of homogeneity/heterogeneity of response rates among subpopulations, and (b) those using borrowed response rate information across subpopulations to improve the statistical efficiency using Bayesian hierarchical models. In this study, we developed a new basket trial design that accounts for the uncertainties of homogeneity and heterogeneity of response rates among subpopulations using the Bayesian model averaging approach. We demonstrated the utility of the proposed method by comparing our approach against other methods for the two methodological groups using simulated and actual data. On an average, the proposed methods offered an intermediate performance between the BHM‐weak and BHM‐strong methods. The proposed method would be useful for “signal‐finding” basket trials without prior information on the treatment effect of an investigational drug, in part because the proposed method does not require specifications regarding prior distributions of homogeneity response rates among subpopulations.
Space–time surveillance of count data subject to linear trends
Authors: Vanli O. Arda , Alawad Nour 
Published: August 2020

AbstractThis paper proposes a new space–time cumulative sum (CUSUM) approach for detecting changes in spatially distributed Poisson count data subject to linear drifts. We develop expressions for the likelihood ratio test monitoring statistics and the change point estimators. The effectiveness of the proposed monitoring approach in detecting and identifying trend‐type shifts is studied by simulation under various shift scenarios in regional counts. It is shown that designing the space–time monitoring approach specifically for linear trends can enhance the change point estimation accuracy significantly. A case study for male thyroid cancer outbreak detection is presented to illustrate the application of the proposed methodology in public health surveillance.