bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Import Sales Contract System in Shanghai 1903–1918, with Special Reference to US–Chinese Commercial Disputes
Authors: Motono Eiichi 
Published: July 2020

AbstractThis article is part of my series of articles that deal with the Western and Chinese commercial disputes from the 1880s until the outbreak of the Sino-Japanese War. In contrast to my previous articles, it deals with commercial disputes between American mercantile firms and Chinese trading merchants in the early twentieth century by examining the unpublished Shanghai American consular archives at NARA II (National Archives and Records Administration), College Park, Maryland. Together with correspondence in the North-China Herald (NCH), these archives can be materials for revealing the peculiar behavior of the proprietors of Chinese partnership (joint-share, or hegu 合股) firms. They cooperated with American mercantile firms so long as the assets of American mercantile firms could guarantee their commercial profits. Whenever they were aware that American mercantile firms could no longer guarantee the safety of their commercial assets, they did not hesitate in breaching commercial contracts by means of various tactics. Seen from the American side, it was nothing but a betrayal. Following typical cases in the records, this article reveals the process by which these commercial disputes escalated to such a level that leaders of Chinese mercantile people demanded reforms to the commercial court system at the end of the 1910s.
DYNAMIC HYPERINTENSIONAL BELIEF REVISION
Authors: ÖZGÜN AYBÜKE , BERTO FRANCESCO 
Published: July 2020

AbstractWe propose a dynamic hyperintensional logic of belief revision for non-omniscient agents, reducing the logical omniscience phenomena affecting standard doxastic/epistemic logic as well as AGM belief revision theory. Our agents don’t know all a priori truths; their belief states are not closed under classical logical consequence; and their belief update policies are such that logically or necessarily equivalent contents can lead to different revisions. We model both plain and conditional belief, then focus on dynamic belief revision. The key idea we exploit to achieve non-omniscience focuses ontopic-orsubject matter-sensitivity: a feature of belief states which is gaining growing attention in the recent literature.
UNIVERSISM AND EXTENSIONS OFV
Authors: ANTOS CAROLIN , BARTON NEIL , FRIEDMAN SY-DAVID 
Published: July 2020

AbstractA central area of current philosophical debate in the foundations of mathematics concerns whether or not there is a single, maximal, universe of set theory. Universists maintain that there is such a universe, while Multiversists argue that there are many universes, no one of which is ontologically privileged. Often model-theoretic constructions that add sets to models are cited as evidence in favor of the latter. This paper informs this debate by developing a way for a Universist to interpret talk that seems to necessitate the addition of sets toV. We argue that, despite the prima facie incoherence of such talk for the Universist, she nonetheless has reason to try and provide interpretation of this discourse. We present a method of interpreting extension-talk (V-logic), and show how it captures satisfaction in ‘ideal’ outer models and relates to impredicative class theories. We provide some reasons to regard the technique as philosophically virtuous, and argue that it opens new doors to philosophical and mathematical discussions for the Universist.
THE LOGIC OF SEQUENCE FRAMES
Authors: LAMPERT FABIO 
Published: July 2020

AbstractThis paper investigates and develops generalizations of two-dimensional modal logics to any finite dimension. These logics are natural extensions of multidimensional systems known from the literature on logics for a priori knowledge. We prove a completeness theorem for propositional n-dimensional modal logics and show them to be decidable by means of a systematic tableau construction.
Arctic Continental Margin Sediments as Possible Fe and Mn Sources to Seawater as Sea Ice Retreats: Insights From the Eurasian Margin
Authors: Tessin Allyson , März Christian , Blais Marie‐Amélie , Brumsack Hans‐Juergen , Matthiessen Jens , O'Regan Matt , Schnetger Bernhard 
Published: July 2020

AbstractContinental margins are hot spots for iron (Fe) and manganese (Mn) cycling. In the Arctic Ocean, these depositional systems are experiencing rapid changes that could significantly impact biogeochemical cycling. In this study, we investigate whether continental margin sediments north of Svalbard represent a source or sink of Fe and Mn to the water column and how climate change might alter these biogeochemical cycles. Our results highlight that sediments on the Yermak Plateau and Sofia Basin exhibit accumulations of Fe and Mn phases compared to average shale. Conversely, sediments from the Barents Sea slope exhibit lower enrichments of Fe and Mn compared to average shale, with the exception of enriched, near‐surface sediment layers. Pore waters from these slope sites provide evidence for Fe and Mn reduction and diffusion of Fe and Mn into near surface sediments, which are susceptible to physical or biogeochemical remobilization. These regional patterns are best explained by the spatial distribution of sea ice coverage and labile organic carbon fluxes to the seafloor. As sea ice continues to retreat and the Yermak Plateau becomes seasonally ice‐free, productivity is expected to increase, which would increase the flux of carbon to the sediments, thereby increasing oxidant demand, and the reduction of Fe and Mn mineral phases. Our results suggest that as sea ice continues to retreat, the Yermak Plateau and other Arctic continental margins could become sources of Fe and Mn to Arctic bottom waters.
Wind Stress‐Induced Multiyear Predictability of Annual Extratropical North Atlantic Sea Surface Temperature Anomalies
Authors: Reintges A. , Latif M. , Bordbar M. H. , Park W. 
Published: July 2020

AbstractLong‐term predictability of the North Atlantic sea surface temperature (SST) is commonly attributed to buoyancy‐forced changes of the Atlantic Meridional Overturning Circulation. Here we investigate the role of surface wind stress forcing in decadal hindcasts as another source of extratropical North Atlantic SST predictability. For this purpose, a global climate model is forced by reanalysis (ERA‐interim) wind stress anomalies over the period 1979–2017. The simulated climate states serve as initial conditions for decadal hindcasts. Significant skill in predicting detrended observed annual SST anomalies is observed over the extratropical central North Atlantic with anomaly correlation coefficients exceeding 0.6 at lead times of 4 to 7 yrs. The skill is insensitive to the calendar month of initialization and primarily linked to upper ocean heat content anomalies that lead anomalous SSTs by several years.
Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers
Authors: Sun Shenfei , Jiang Ning , Jiang Yamei , He Qiuping , He Hua , Wang Xin , Yang Li , Li Runsheng , Liu Feng , Lin Xinhua , Zhao Bing 
Published: July 2020

AbstractHematopoietic stem cell (HSC) utilizes its quiescence feature to combat exhaustion for lifetime blood cell supply. To date, how certain chromatin architecture and subsequent transcription profile permit HSC quiescence remains unclear. Here, we show an essential role of chromatin remodeler zinc finger HIT-type containing 1 (Znhit1) in maintaining HSC quiescence. We find that loss of Znhit1 leads to exhaustion of stem cell pool and impairment of hematopoietic function. Mechanically, Znhit1 determines the chromatin accessibility at distal enhancers of HSC quiescence genes, including Pten, Fstl1, and Klf4, for sustained transcription and consequent PI3K–Akt signaling inhibition. Moreover, Znhit1–Pten–PI3K–Akt axis also participates in controlling myeloid expansion and B-lymphoid specification. Our findings therefore identify a dominant role of Znhit1-mediated chromatin remodeling in preserving HSC function for hematopoietic homeostasis.
Immunotherapy in older patients with non-small cell lung cancer: Young International Society of Geriatric Oncology position paper
Authors: Gomes Fabio , Wong Melisa , Battisti Nicolò Matteo Luca , Kordbacheh Tiana , Kiderlen Mandy , Greystoke Alastair , Luciani Andrea 
Published: July 2020

AbstractImmunotherapy with checkpoint inhibitors against programmed cell death receptor (PD-1) and programmed cell death ligand (PD-L1) has been implemented in the treatment pathway of patients with non-small cell lung cancer (NSCLC) from locally advanced disease to the metastatic setting. This approach has resulted in improved survival and a more favourable toxicity profile when compared with chemotherapy. Following the successful introduction of single-agent immunotherapy, current clinical trials are focusing on combination treatments with chemotherapy or radiotherapy or even other immunotherapeutic agents. However, most of the data available from these trials are derived from, and therefore might be more applicable to younger and fitter patients rather than older and often frail lung cancer real-world patients. This article provides a detailed review of these immunotherapy agents with a focus on the data available regarding older NSCLC patients and makes recommendations to fill evidence gaps in this patient population.
Structure and distribution of chalky deposits in the Pacific oyster using x-ray computed tomography (CT)
Authors: Banker Roxanne M. W. , Sumner Dawn Y. 
Published: July 2020

AbstractOysters are unusual among bivalves in that they possess chambers, often filled with soft, chalky calcite, that are irregularly scattered throughout the shell. Because the function of these so-called chalky deposits is still unclear, evaluating the growth and distribution of chalk is important for elucidating the ecological function of this unique shell trait. Specimens of the Pacific oysterMagallana gigas, an oyster well known for chalk expression, were grown in Bodega Harbor, Bodega Bay, CA. At the end of an 11 month growing period, specimens were culled and selected animals were submitted for x-ray computed-tomography imaging. Three-dimensional reconstructions of oyster shells were used to assess the overall distribution of chalk, and also to better understand the relationship between chalk and other structures within the shell. Results indicate that chalky deposits underly sculptural features on the shell exterior, such as external ridges and changes in growth direction, and also that there is a relationship between chalk formation and oyster processes of cementation. Overall, chalk is useful for a cementing lifestyle because it enables morphological plasticity needed to conform to irregular substrates, but also acts as a cheap building material to facilitate rapid growth.
Selection of mutant µplasmin for amyloid-β cleavage in vivo
Authors: Yang Dongying , Zhu Wei , Wang Yingjie , Tan Fangmei , Ma Zhiping , Gao Jiali , Lin Xinli 
Published: July 2020

AbstractOne of the main culprits of Alzheimer’s disease (AD) is the formation of toxic amyloid-β (Aβ) peptide polymers and the aggregation of Aβ to form plaques in the brain. We have developed techniques to purify the catalytic domain of plasmin, micro-plasmin (µPlm), which can be used for an Aβ-clearance based AD therapy. However, in serum, µPlm is irreversibly inhibited by its principal inhibitor α2-antiplasmin (α2-AP). In this study, we engineered and selected mutant forms of µPlm that are both catalytically active and insensitive to α2-AP inhibition. We identified surface residues of μPlm that might interact and bind α2-AP, and used an alanine-scanning mutagenesis method to select residues having higher activity but lower α2-AP inhibition. Then we employed saturation mutagenesis for further optimize both properties. Modeled complex structure of µPlm/α2-AP shows that F587 is a critical contact residue, which can be used as a starting position for further investigation.
An osmolality/salinity-responsive enhancer 1 (OSRE1) in intron 1 promotes salinity induction of tilapia glutamine synthetase
Authors: Kim Chanhee , Kültz Dietmar 
Published: July 2020

AbstractEuryhaline tilapia (Oreochromis mossambicus) are fish that tolerate a wide salinity range from fresh water to > 3× seawater. Even though the physiological effector mechanisms of osmoregulation that maintain plasma homeostasis in fresh water and seawater fish are well known, the corresponding molecular mechanisms that control switching between hyper- (fresh water) and hypo-osmoregulation (seawater) remain mostly elusive. In this study we show that hyperosmotic induction of glutamine synthetase represents a prominent part of this switch. Proteomics analysis of the O. mossambicus OmB cell line revealed that glutamine synthetase is transcriptionally regulated by hyperosmolality. Therefore, the 5′ regulatory sequence of O. mossambicus glutamine synthetase was investigated. Using an enhancer trapping assay, we discovered a novel osmosensitive mechanism by which intron 1 positively mediates glutamine synthetase transcription. Intron 1 includes a single, functional copy of an osmoresponsive element, osmolality/salinity-responsive enhancer 1 (OSRE1). Unlike for conventional enhancers, the hyperosmotic induction of glutamine synthetase by intron 1 is position dependent. But irrespective of intron 1 position, OSRE1 deletion from intron 1 abolishes hyperosmotic enhancer activity. These findings indicate that proper intron 1 positioning and the presence of an OSRE1 in intron 1 are required for precise enhancement of hyperosmotic glutamine synthetase expression.
Manganese-induced neurotoxicity in cerebellar granule neurons due to perturbation of cell network pathways with potential implications for neurodegenerative disorders
Authors: Hernández Raúl Bonne , Carrascal Montserrat , Abian Joaquin , Michalke Bernhard , Farina Marcelo , Gonzalez Yasmilde Rodriguez , Iyirhiaro Grace O , Moteshareie Houman , Burnside Daniel , Golshani Ashkan , Suñol Cristina 
Published: July 2020

AbstractManganese (Mn) is essential for living organisms, playing an important role in nervous system function. Nevertheless, chronic and/or acute exposure to this metal, especially during early life stages, can lead to neurotoxicity and dementia by unclear mechanisms. Thus, based on previous works of our group with yeast and zebrafish, we hypothesized that the mechanisms mediating manganese-induced neurotoxicity can be associated with the alteration of protein metabolism. These mechanisms may also depend on the chemical speciation of manganese. Therefore, the current study aimed at investigating the mechanisms mediating the toxic effects of manganese in primary cultures of cerebellar granule neurons (CGNs). By exposing cultured CGNs to different chemical species of manganese ([[2-[(dithiocarboxy)amino]ethyl]carbamodithioato]](2-)-kS,kS′]manganese, named maneb (MB), and [[1,2-ethanediylbis[carbamodithioato]](2-)]manganese mixture with [[1,2-ethanediylbis[carbamodithioato]](2-)]zinc, named mancozeb (MZ), and manganese chloride (MnCl2)), and using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, we observed that both MB and MZ induced similar cytotoxicity (LC50 ∼ 7–9 μM), which was higher than that of MnCl2 (LC50 ∼ 27 μM). Subsequently, we applied systems biology approaches, including metallomics, proteomics, gene expression and bioinformatics, and revealed that independent of chemical speciation, for non-cytotoxic concentrations (0.3–3 μM), Mn-induced neurotoxicity in CGNs is associated with metal dyshomeostasis and impaired protein metabolism. In this way, we verified that MB induced more post-translational alterations than MnCl2, which can be a plausible explanation for cytotoxic differences between both chemical species. The metabolism of proteins is one of the most energy consuming cellular processes and its impairment appears to be a key event of some cellular stress processes reported separately in other studies such as cell cycle arrest, energy impairment, cell signaling, excitotoxicity, immune response, potential protein accumulation and apoptosis. Interestingly, we verified that Mn-induced neurotoxicity shares pathways associated with the development of Alzheimer's disease, Amyotrophic Lateral Sclerosis, Huntington's disease, and Parkinson's disease. This has been observed in baker's yeast and zebrafish suggesting that the mode of action of Mn may be evolutionarily conserved.
Common Configurations of Real-Ear Aided Response Targets Prescribed by NAL-NL2 for Older Adults With Mild-to-Moderate Hearing Loss
Authors: Jensen Justin , Vyas Dhruv , Urbanski Dana , Garudadri Harinath , Chipara Octav , Wu Yu-Hsiang 
Published: July 2020

Purpose
This study investigates common real-ear aided response (REAR) configurations prescribed by the NAL-NL2 algorithm for older adults with hearing loss.

Method
A data set that is representative of the older adult U.S. population with mild-to-moderate sensorineural hearing loss was constructed from the audiometric data of 934 adults (aged 55–85 years) from the National Health and Nutrition Examination Survey years 1999–2012. Two clustering approaches were implemented to generate common REAR configurations for eight frequencies (0.25, 0.5, 1, 2, 3, 4, 6, and 8 kHz) at three input levels (55, 65, and 75 dB SPL). (a) In the REAR-based clustering approach, the National Health and Nutrition Examination Survey audiograms were first converted to REAR targets and then clustered to generate common REAR configurations. (b) In the audiogram-based clustering approach, the audiograms were first clustered into common hearing loss profiles and then converted to REAR configurations. The trade-off between the number of available REAR configurations and the percentage of the U.S. population whose hearing loss could be fit by at least one of them (i.e., percent coverage) was evaluated. Hearing loss fit was defined as less than ± 5-dB difference between an individual's REAR targets and those of the clustered REAR configuration.

Results
Percent coverage increases with the number of available REAR configurations, with four configurations resulting in 75% population coverage. Overall, REAR-based clustering yielded 5 percentage points better coverage on average compared to audiogram-based clustering.

Conclusions
The common REAR configurations can be used for programming the gain frequency responses in preconfigured over-the-counter hearing aids and provide clinically appropriate amplification settings for older adults with mild-to-moderate hearing loss.
Iron-Catalyzed Aerobic Oxidative Cross-Dehydrogenative C(sp3)–H/X–H (X = C, N, S) Coupling Reactions
Authors: Xu Da-Zhen , Hu Ren-Ming , Lai Yi-Huan 
Published: July 2020

The direct functionalization of C(sp3)–H bonds is an attractive research topic in organic synthetic chemistry. The cross-dehydrogenative coupling (CDC) reaction provides a simple and powerful tool for the construction of C–C and C–heteroatom bonds. Recently, some progress has been made in the iron-catalyzed aerobic oxidative CDC reactions. Here, we present recent developments in the direct functionalization of C(sp3)–H bonds catalyzed by simple iron salts with molecular oxygen as the terminal oxidant.1	Introduction2	C(sp3)–C Bond Formation3	C(sp3)–N Bond Formation4	C(sp3)–S(Se) Bond Formation5	Conclusion and Outlook
Cancer and Pregnancy: National Trends
Authors: Ma Kimberly K. , Monsell Sarah E. , Chandrasekaran Suchitra , Gadi Vijayakrishna K. , Gammill Hilary S. 
Published: July 2020

Objective Cancer and pregnancy are likely increasing; however, updated estimates are needed to optimally address the unique needs of this patient population. The study aims to estimate the prevalence of cancer and cancer survivorship at delivery, to test the change in odds of cancer and cancer survivorship at delivery over the 10-year period, and to compare medical conditions, serious events, and obstetric complications between pregnancies with and without cancer at delivery.
Study Design We conducted a retrospective analysis of the National Inpatient Sample (NIS), the largest all-payer inpatient health database in the United States. We identified delivery admissions from 2004 to 2013 with a concurrent diagnosis of cancer using International Classification of Disease, ninth revision (ICD-9) codes. Multivariable logistic regression was used to test the change in prevalence of concurrent cancer, cancer survivorship, and pregnancy and to compare outcomes between deliveries with and without cancer. All analyses were adjusted for NIS-provided population weights and strata.
Results During the study period, the NIS represented a national estimate of 40,855,208 deliveries. The odds of cancer increased from 3.41/10,000 deliveries in 2004 to 4.33/10,000 in 2013. This trend was statistically significant, including after adjustment for maternal age (adjusted odds ratio [aOR] = 1.03 [95% confidence interval (CI): 1.01–1.04]). Cancer survivorship at delivery increased significantly (aOR = 1.07 [95% CI: 1.06–1.08]). Women with cancer more often experienced one or more of the following: death, ventilation, cardiac arrest, sepsis, or acute respiratory or renal failure during delivery (aOR for composite outcome 10.7 [95% CI: 6.6–17.2]), even after adjustment in a multivariable logistic regression model.
Conclusion The odds of cancer and cancer survivorship at delivery increased from 2004 to 2013, independent of maternal age. Women with cancer were more likely to experience medical or obstetric complications during their delivery compared with women without cancer. These findings highlight the importance of obstetric and oncologic clinical and research collaboration to improve patient care.
Key Points
A single-cell Raman-based platform to identify developmental stages of human pluripotent stem cell-derived neurons
Authors: Hsu Chia-Chen , Xu Jiabao , Brinkhof Bas , Wang Hui , Cui Zhanfeng , Huang Wei E. , Ye Hua 
Published: July 2020

SignificanceWe developed a label-free and noninvasive single-cell Raman microspectroscopy (SCRM)-based platform to identify neural cell lineages derived from clinically relevant human induced pluripotent stem cells (hiPSCs). Through large-scale Raman spectral analysis, we can distinguish hiPSCs and hiPSC-derived neural cells using their intrinsic biochemical profile. We identified glycogen as a Raman biomarker for neuronal differentiation and validated the results using conventional glycogen detection assays. The parameters obtained from SCRM were processed by a novel machine learning method based on t-distributed stochastic neighbor embedding (t-SNE)-enhanced ensemble stacking, enabling highly accurate and robust cell classification. The platform and the proposed biomarker should also be applicable to other cell types and can shed light on developmental biology and glycogen metabolism disorders.
Long-range intramolecular allostery and regulation in the dynein-like AAA protein Mdn1
Authors: Mickolajczyk Keith J. , Olinares Paul Dominic B. , Niu Yiming , Chen Nan , Warrington Sara E. , Sasaki Yusuke , Walz Thomas , Chait Brian T. , Kapoor Tarun M. 
Published: July 2020

Significance
The dynein-like AAA motor Mdn1 drives ribosome biogenesis by using ATP-fueled motions to dislodge assembly factor proteins from 60S precursor particles. It is not known how this unusually large (>500 kDa) mechanoenzyme coordinates the activities of its C-terminal MIDAS domain, which binds specific preribosomal proteins, with the ATPase cycle in its N-terminal AAA ring. Here, we show that the linking domains, which include a >500-amino acid disordered region, regulate an intramolecular binding interaction between the AAA and MIDAS domains. Surprisingly, the linking domains down-regulate MIDAS-AAA binding despite tethering these two domains together. This study provides insights into the regulation of Mdn1 function and into the design principles of large, multidomain mechanoenzymes.