bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective Effects of Astaxanthin on Nephrotoxicity in Rats with Induced Renovascular Occlusion
Authors: Arslan Erkan , Turk Hakan , Caglayan Murat , Turkmenoglu Tugba Taskin , Gonel Ataman , Tayman Cuneyt 
Published: September 2020

Background:
Various effects of Astaxanthin was shown in the studies including its antioxidant, anti-inflammatory, anti-tumor
and immunregulator effects.

Objective:
The aim of this study was to evaluate the beneficial effects of Astaxanthin on renovascular occlusion induced renal injury and to
investigate the possible mechanisms.

Methods:
The rats were randomly assigned into three groups as follows: Group 1: control group (n=12), Group 2: renal ischemiareperfusion injury group (n=12), Group 3: renal ischemia-reperfusion + asthaxantine treated group (n=12). The control group and the renal
ischemia-reperfusion group were given 2cc/kg/g olive oil for 7 days before establishing ischemia to renal tissue. Astaxanthin dissolved in
olive oil was given orally to the renal ischemia+astaxanthin group for 7 days before inducing renal ischemia. Caspase-(3, 8, 9), GSH, SOD,
Total Thiol, TNF-α, IL-6, 8-OHdG were performed for each group.

Results:
Renal IRI was verified by analysing the pathological changes of renal tissues and the renal functions after renal reperfusion. Much
less renal tubular damage was determined the IRI+ASX group in comparison to the IRI group. Caspase-8, -9 and -3 immunoreactivity was
observed to be minimal in the control group. Apoptosis was observed to be significantly reduced in the IRI + ASX group with respect to IRI
group and close to the level of the control group (p <0.05). Caspase-3 levels of tissue samples were significantly increased in IRI group
compared to other groups, but significantly lower in IRI+ASX group with respect to the IRI group (p<0.05). The TOS and OSI levels, indicating increased oxidative stress, were significantly lower in the IRI+ASX group with respect to the IRI group (p <0.001), but still higher
than the control group (p <0.001). In addition to GSH, SOD and Total Thiol levels, TAS levels were also significantly higher in IRI + ASX
group in comparison to the IRI group (p <0.05). TNF-α, IL-6, lipid hydroperoxide, AOPP and 8-OHdG levels were lower in the IRI+ASX
group than the IRI group (p <0.001). MPO, IL-6, TNF-α levels, representing the parameters indicating neutrophil infiltration and inflammation of the renal tissues, significantly increased in IRI group with respect to the other groups (p <0.005).

Conclusion:
When all the data obtained in our study were evaluated, ASX was determined to prevent renal damage due to renovascular occlusion to a great extent, through complex mechanisms involving antioxidant, anti-inflammatory and antiapopitotic effects. Biochemical,
histological and oxidative stress parameters were improved due to ASX.
Anastatica hierochuntica Extracts: Promising, Safe and Selective Anticancer
Agents
Authors: Al-Eisawi Zaynab , Abderrahman Salim M. , Abdelrahim Yasmin M. S. , Al-Abbassi Reem , Bustanji Yasser K. 
Published: September 2020

Background:
Medicinal plants have been used for many centuries for their significant phytochemical reservoir,
forming a foundation for many medicinal drugs. Conventional cancer therapy possesses a number of undesired problems
including poor selectivity, severe side effects and resistance of cancer.

Objective:
There is a need for new anticancer drugs possibly from natural sources such as medicinal plants. A. Hierochuntica
L. is rich with phytochemicals and is widely used in traditional medicine.

Method:
The antiproliferative activities of A. hierochuntica whole plant extracts (ethanol, methanol, ethyl acetate,
chloroform and water) were determined against a panel of cancer cells and normal primary dermal fibroblasts. The genotoxic
effect of A. hierochuntica ethyl acetate on mice bone marrow cells was also evaluated. Genotoxic parameters included
Chromosomal aberration, Mitodepression, Micronuclei formation and sister chromatid exchange.

Results:
A. hierochuntica exhibited antiproliferative activity against leukemia (K-562) and melanoma (A-375) cells. This
is the first study to demonstrate the effect of A. hierochuntica ethyl acetate extract on cancer cell lines, found to be the most
cytotoxic of all extracts. Furthermore, the chloroform extract showed notable anti-proliferative effects against most cancer
cell lines tested. The extracts proved to be highly safe on human normal skin fibroblasts. Furthermore, A. hierochuntica
ethyl acetate extract was also found to have limited genotoxic effects, with these changes seen at very high doses only.

Conclusion:
The results indicate that A. hierochuntica extracts have significant selective anticancer activity and that
genotoxicity is only observed at very high concentrations.
Effects of the COVID-19 Pandemic on Obsessive-Compulsive Symptoms Among University Students: Prospective Cohort Survey Study
Authors: Ji Guangjun , Wei Wenjun , Yue Kai-Chen , Li Heng , Shi Li-Jing , Ma Jian-Dong , He Chen-Yang , Zhou Sheng-Sheng , Zhao Zongya , Lou Tao , Cheng Jie , Yang Shi-Chang , Hu Xian-Zhang 
Published: September 2020

BackgroundThe COVID-19 pandemic is associated with common mental health problems. However, evidence for the association between fear of COVID-19 and obsessive-compulsive disorder (OCD) is limited.ObjectiveThis study aimed to examine if fear of negative events affects Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) scores in the context of a COVID-19–fear-invoking environment.MethodsAll participants were medical university students and voluntarily completed three surveys via smartphone or computer. Survey 1 was conducted on February 8, 2020, following a 2-week-long quarantine period without classes; survey 2 was conducted on March 25, 2020, when participants had been taking online courses for 2 weeks; and survey 3 was conducted on April 28, 2020, when no new cases had been reported for 2 weeks. The surveys comprised the Y-BOCS and the Zung Self-Rating Anxiety Scale (SAS); additional items included questions on demographics (age, gender, only child vs siblings, enrollment year, major), knowledge of COVID-19, and level of fear pertaining to COVID-19.ResultsIn survey 1, 11.3% of participants (1519/13,478) scored ≥16 on the Y-BOCS (defined as possible OCD). In surveys 2 and 3, 3.6% (305/8162) and 3.5% (305/8511) of participants had scores indicative of possible OCD, respectively. The Y-BOCS score, anxiety level, quarantine level, and intensity of fear were significantly lower at surveys 2 and 3 than at survey 1 (P<.001 for all). Compared to those with a lower Y-BOCS score (<16), participants with possible OCD expressed greater intensity of fear and had higher SAS standard scores (P<.001). The regression linear analysis indicated that intensity of fear was positively correlated to the rate of possible OCD and the average total scores for the Y-BOCS in each survey (P<.001 for all). Multiple regressions showed that those with a higher intensity of fear, a higher anxiety level, of male gender, with sibling(s), and majoring in a nonmedicine discipline had a greater chance of having a higher Y-BOCS score in all surveys. These results were redemonstrated in the 5827 participants who completed both surveys 1 and 2 and in the 4006 participants who completed all three surveys. Furthermore, in matched participants, the Y-BOCS score was negatively correlated to changes in intensity of fear (r=0.74 for survey 2, P<.001; r=0.63 for survey 3, P=.006).ConclusionsOur findings indicate that fear of COVID-19 was associated with a greater Y-BOCS score, suggesting that an environment (COVID-19 pandemic) × psychology (fear and/or anxiety) interaction might be involved in OCD and that a fear of negative events might play a role in the etiology of OCD.
Intimate Partner Violence and Electronic Health Interventions: Systematic Review and Meta-Analysis of Randomized Trials
Authors: Linde Ditte S , Bakiewicz Aleksandra , Normann Anne Katrine , Hansen Nina Beck , Lundh Andreas , Rasch Vibeke 
Published: September 2020

Background
Intimate partner violence (IPV) is a major public health concern. eHealth interventions may reduce exposure to violence and health-related consequences as the technology provides a safe and flexible space for the target population. However, the evidence is unclear.

Objective
The goal of the review is to examine the effect of eHealth interventions compared with standard care on reducing IPV, depression, and posttraumatic stress disorder (PTSD) among women exposed to IPV.

Methods
We searched EMBASE, MEDLINE, Cochrane Central Register of Controlled Trials, PsycInfo, Scopus, Global Health Library, ClinicalTrials.gov, and International Clinical Trials Registry Platform for published and unpublished trials from inception until April 2019. Trials with an eHealth intervention targeting women exposed to violence were included. We assessed risk of bias using the Cochrane Risk of Bias Tool. Trials that reported effect estimates on overall IPV; physical, sexual, and psychological violence; depression; or posttraumatic stress disorder were included in meta-analyses.

Results
A total of 14 trials were included in the review; 8 published trials, 3 unpublished trials and 3 ongoing trials. Of the 8 published trials, 2 were judged as overall low risk of bias trials. The trials reported 23 types of outcomes, and 7 of the trials had outcomes that were eligible for meta-analyses. Our pooled analyses found no effect of eHealth interventions on any of our prespecified outcomes: overall IPV (SMD –0.01; 95% CI –0.11 to 0.08; I2=0%; 5 trials, 1668 women); physical violence (SMD 0.01; 95% CI –0.22 to 0.24; I2=58%; 4 trials, 1128 women); psychological violence (SMD 0.07; 95% CI –0.12 to 0.25; I2=40%; 4 trials, 1129 women); sexual violence (MD 0.36; 95% CI –0.18 to 0.91; I2=0%; 2 trials, 1029 women); depression (SMD –0.13; 95% CI –0.37 to 0.11; I2=78%; 5 trials, 1600 women); and PTSD (MD –0.11; 95% CI –1.04 to 0.82; I2=0%; 5 trials, 1267 women).

Conclusions
There is no evidence from randomized trials of a beneficial effect of eHealth interventions on IPV. More high-quality trials are needed, and we recommend harmonizing outcome reporting in IPV trials by establishing core outcome sets.

Trial Registration
PROSPERO International Prospective Register of Systematic Reviews CRD42019130124; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=130124
A Digitally Competent Health Workforce: Scoping Review of Educational Frameworks
Authors: Nazeha Nuraini , Pavagadhi Deepali , Kyaw Bhone Myint , Car Josip , Jimenez Geronimo , Tudor Car Lorainne 
Published: September 2020

Background
Digital health technologies can be key to improving health outcomes, provided health care workers are adequately trained to use these technologies. There have been efforts to identify digital competencies for different health care worker groups; however, an overview of these efforts has yet to be consolidated and analyzed.

Objective
The review aims to identify and study existing digital health competency frameworks for health care workers and provide recommendations for future digital health training initiatives and framework development.

Methods
A literature search was performed to collate digital health competency frameworks published from 2000. A total of 6 databases including gray literature sources such as OpenGrey, ResearchGate, Google Scholar, Google, and websites of relevant associations were searched in November 2019. Screening and data extraction were performed in parallel by the reviewers. The included evidence is narratively described in terms of characteristics, evolution, and structural composition of frameworks. A thematic analysis was also performed to identify common themes across the included frameworks.

Results
In total, 30 frameworks were included in this review, a majority of which aimed at nurses, originated from high-income countries, were published since 2016, and were developed via literature reviews, followed by expert consultations. The thematic analysis uncovered 28 digital health competency domains across the included frameworks. The most prevalent domains pertained to basic information technology literacy, health information management, digital communication, ethical, legal, or regulatory requirements, and data privacy and security. The Health Information Technology Competencies framework was found to be the most comprehensive framework, as it presented 21 out of the 28 identified domains, had the highest number of competencies, and targeted a wide variety of health care workers.

Conclusions
Digital health training initiatives should focus on competencies relevant to a particular health care worker group, role, level of seniority, and setting. The findings from this review can inform and guide digital health training initiatives. The most prevalent competency domains identified represent essential interprofessional competencies to be incorporated into health care workers’ training. Digital health frameworks should be regularly updated with novel digital health technologies, be applicable to low- and middle-income countries, and include overlooked health care worker groups such as allied health professionals.
The effect of midwife training in strengthening the mental health of postpartum mother
Authors: Sumarni Sumarni , Prawitasari Shinta , Putri Ika 
Published: September 2020

Most midwives in the Cangkringan Community Health Center and Pakem Health Center are not familiar with the symptoms of blues depression. Data shows that in Cangkringan Community Health Center, blues depression occurs 60%, 2 cases due to delayed treatment (the mother almost killed her baby). In the Pakem Health Center area, blues depression occurs at 48.1%, 2 cases experience postpartum depression due to late handling, 1 mother tries suicide. If blues depression is not handled properly and immediately, it would cause postpartum depression, which can cause the worst complications, namely postpartum psychosis. One effort to overcome this is by providing midwife training on early detection and handling of blues depression accompanied by social support. Social support and spiritual training held in six steps (once in a week a during 1,5 months. The tools in this research consist of early detection for blues depression module, social support and spiritual for blues depression prevention, Edinburgh Postnatal Depression Scale questionnaire, knowledge, and skill of blues depression early detection module and social support and spiritual questionnaire. The method in this research use presentation, discussion, role-play, practice, association, and implementation. Analyze data using the quantitative descriptive approach. Research subjects are consist of 47 midwives in the Cangkringan Community Health Center and Pakem Health Center Area and 67 postpartum women in the Cangkringan Community Health Center and Pakem Health Center Area. The results show the average value of blues depression prevention knowledge is 43.45 after training increases 85,20. The average value of blues depression early detection knowledge is 57.56; after training increase 91,27. The average value of Blues depression prevention skills is 36.45, after training increase 80,25, and the average value of blues depression early detection is 51.30, after training increase 90,20. Blues Depression in postpartum women in the Cangkringan and Pakem health centers is 57%. Changes in the average value of knowledge about blues depression control before training were 43.45% to 85.20% after training increased 41.75. Changes in the average value of skills regarding prevention and early detection of blues depression before training amounted to 36.45 to 80.85 after training increased by 44.40. The whole series of training midwives in the Cangkringan Community Health Center and Pakem Health Center Area can improve the knowledge and skills of midwives to overcome blues depression in postpartum women, reduce the incidence of blues depression in postpartum women, and reduce maternal and child mortality due to postpartum mental disorders.
User acquisition and profile of COVID-19’s health education website: a descriptive study
Authors: Lestari Avinindita Nura , Leksono Tiara Putri , Khaidar Reyfal , Alam Ekky Novriza , Lazuardi Lutfan 
Published: September 2020

In early of 2020, China had identified a new etiology of pneumonia which was later called Coronavirus Disease 2019 (COVID-19) by the World Health Organization (WHO) and the condition declared as pandemic. In this emergency state of affair, people will seek information from websites disseminating health information online, including Indonesia. Since there is currently no vaccine or specific antiviral treatment, the application of preventive measures has been essential. The hygiene and health measures can be easily spread widely as there’s been fast & numerous information spreading in the media, but that is not usually the case with underprivileged people with little access to technology. False news and lack of credible sources are also a threat. A health startup in Bandung, Indonesia, made initiatives to educate people about COVID-19 prevention through downloadable script and audio in the form of Public Service Announcement provided with 19 local languages through their website. This study aims to know the characteristics of profile users accessing the website through descriptive observational approach. The data came from the website automatically analysed by Google Analytics. We look into the audience data, comprising demographics and geographical distribution. Additionally, we observe the acquisition data that helps us in seeing website traffic. The significant difference found in this study is seen in the age group, meanwhile the gender group did not have a significant difference, which has 8% of disparity. By geographical distribution, 60% of top users are located in cities located in Java Island. Direct traffic, interestingly, made up almost 86 percent of all traffic. Twitter ranked the top for the social media traffic in our case. In conclusion, it is necessary to promote credible information in COVID-19 preventive measures and help maintain the accessibility of information.
Sobre Francisco Javier de la Torre Galindo “Recorrer y participar en la Ciudad. Tres aproximaciones a la adaptación de los recorridos comentados como técnica de la investigación urbana”, 2018, ISBN: 978-607-28-1212-3
Authors: Filippe Narciso Carla Alexandra 
Published: September 2020

En estre trabajo se hace una aproximación crítica al libro de Francisco Javier de la Torre Galindo, “Recorrer y participar en la Ciudad. Tres aproximaciones a la adaptación de los recorridos comentados como técnica de la investigación urbana”, 2018, ISBN: 978-607-28-1212-3
¿Por qué se incorpora el doctorado profesional al Programa Nacional de Posgrados de Calidad en México?
Authors: Patiño Salceda Josefina 
Published: September 2020

El objetivo en este artículo es responder dos preguntas sobre la incorporación del doctorado profesional al Programa Nacional de Posgrados de Calidad (PNPC), en México, en 2014: ¿cuáles fueron los factores que propiciaron la incorporación? y ¿cuál fue el objetivo de esta decisión? Se trabajó con un enfoque cualitativo a través del análisis de siete entrevistas semiestructuradas realizadas a expertos del tema en el país. Con los resultados se muestra que la incorporación del doctorado profesional se debe a la insatisfacción que provocaron los resultados de impacto de los doctorados de investigación en el sector productivo. Se concluye que las autoridades del PNPC intentan construir un modelo de formación diversificada con doctorados que no solo atiendan los requerimientos de la academia a través de la formación de científicos profesionales, sino también de científicos industriales cuyo destino laboral deseable es el sector gubernamental o empresarial. En Latinoamérica, se ha discutido poco sobre los doctorados profesionales, por lo que la experiencia de México es de gran utilidad para la discusión regional.
Mirar el mar desde las espumas: una mirada al intercambio cultural entre México y Colombia durante los años cuarenta
Authors: Sequeda Garrido Yezid David 
Published: September 2020

El artículo busca dar cuenta de importantes matices de los vínculos extra diplomáticos colombo mexicanos, visibles en el continuo cruce de información ligada con el ámbito de la cultura, la educación y la diplomacia durante un amplio trayecto de la primera mitad del siglo XX. La idea es acercarse al influjo que ejercieron las políticas culturales del gobierno mexicano, en un periodo en que la propaganda y la difusión de un proyecto que apeló a la cultura y a las manifestaciones artísticas de las mayorías, hizo presencia en el entorno de relación de ambos países mientras servía de modo directo a propósitos de cohesión colectiva, en los que expresiones artísticas, manifestaciones folclóricas y diversas tradiciones provenientes del campo mexicano encontraron en este proyecto dirigido, un espacio para su difusión y su apropiación, como formas vinculantes y como enlaces válidos para dar cuenta de la identidad nacional.
Hitsiliitoksen geometrian vaikutus väsymismitoituksessa
Authors: Keränen Lassi , Niskanen Juhani 
Published: September 2020

Tässä tutkimuksessa tarkasteltiin kahdella eri lämmöntuonnilla MAG-hitsattujen päittäisliitosten poikkileikkausten geometriaa sekä hitsiliitoksen geometrian vaikutusta väsymiskestävyyteen lovenvaikutuslukujen avulla S700-lujuusluokan rakenneteräksellä. Hitsiliitosten poikkileikkausten geometriat tuotiin elementtimenetelmäohjelmistoon, jossa määritettiin malli lovenvaikutuslukujen laskemiseksi. Laskettuja lovenvaikutuslukuja verrattiin kirjallisuuteen, sekä lovenvaikutuslukujen avulla määritettiin S‑N ‑käyrät, joita verrattiin mitoitusohjeiden S-N -käyriin. Lisäksi tarkasteltiin elementtikoon vaikutusta lovenvaikutuslukuun sekä alkusärön koon vaikutusta kestoikään murtumismekaniikan avulla. Tutkimuksessa havaittiin, että geometria ei yksin selitä hitsiliitoksen huonompaa väsymiskestävyyttä ehjään perusaineeseen verrattuna, vaan lähes puolet erosta johtuu muusta kuin geometriasta, esimerkiksi hitsauksen aiheuttamista mikrorakenteen muutoksista tai jäännösjännityksistä. Ainoastaan lovenvaikutusluku huomioiden saadaan hitsiliitoksille ylioptimistisia väsymiskestävyyden suuruuksia sekä kirjallisuuteen että mitoitusohjeisiin verrattuna. Elementtimenetelmää mitoituksessa hyödynnettäessä on käytettävä riittävän tiheää elementtiverkkoa, jotta rakenteen ja hitsiliitoksen geometria kuvataan oikein ja laskentajännitykset ovat todellisuutta vastaavia.
POTENSI BAKTERI PELARUT FOSFAT DAN DIAZOTROF DARI RHIZOSFER KELAPA SAWIT TANAH GAMBUT SAPRIK TERHADAP PERTUMBUHAN BIBIT KELAPA SAWIT
Authors: Istina Ida Nur , Widiastuti Happy , Widianto Heri 
Published: September 2020

Utilization of biological fertilizer has the potential to reduce inorganic fertilizer application in oil palm cultivation. The aims of this research to obtain the potential of phosphate (P) solubilizing and diazotrophic bacteria from oil palm rhizosphere towards palm oil seedling growth. This research has been done on Sapric peat soil at Pelalawan Regency, Riau Province from June to November 2014, using a factorial randomized block design (3x5 with 3 replications). The first factor were the potential bacteria isolates (Io = without isolates; I1 = Isolate T5.1 + T7. I2 = Isolate T9.1 + T5); the second factor were NPK fertilizer dosage (p1-100%; p2 = 85%; p3 = 70% fertilizer and p4 = 55% recommended fertilizer). The results showed that sapric peat soil was a potential source of P solubilizing bacteria with the ability to solubilized of P up to 329.94 ppm, and diazotrophic bacteria with the ability of N-fixation up to 0.0293 mmol/L/ hr. Application of 70% N and P fertilizers and i2 isolate provides the best vegetative growth performance of oil palm seedlings and reduces 30% of inorganic fertilizers application.