bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do We Have Another Option to Treat Bleeding Hemorrhoids? The Emborrhoid Technique: Experience in 16 Patients
Authors: Moggia Elisabetta , Talamo Giuseppina , Gallo Gaetano , Bianco Angelo , Barattini Matteo , Salsano Giancarlo , Zefiro Daniele , Stefanini Teseo , Berti Stefano 
Published: March 2020

Background:
Hemorrhoidal disease is very common in western countries and rectal
bleeding is the main symptom complained by patients. Nowadays the ultimate goal of treatment is
to block the bleeding with minimally-invasive techniques to minimize post-procedural pain.

Objective:
The aim of this study is to assess the preliminary results of the emborrhoid technique
(embolization of the superior rectal arteries branches) as a new tool for the proctologist to treat severe
bleeding hemorrhoids causing anemia. Many categories of patients might benefit from this
treatment, such as patients not eligible for conventional surgery, patients not responding to conventional
treatment and fit patients with severe bleeding who refused endorectal surgical therapy.

Methods:
From May 2017 to November 2018 a total of 16 patients with chronic rectal bleeding
due to hemorrhoids underwent super-selective embolization of the superior rectal arteries at the department
of General Surgery in La Spezia, S. Andrea Hospital, Italy. Median age was 59 years. 14
patients were males (87.5%).

Results:
No post-procedural and short-term complications were observed at maximum follow up
(12 months). The reduction of rectal bleeding with improvement of the quality of life was obtained
in 14 patients (87.5%).

Conclusion:
Our study, although small in number, demonstrates that embolization of superior rectal
arteries with coils to treat severe bleeding due to hemorrhoids is safe and effective and does not
lead to immediate complications.
A Lightweight Deep Learning Model for Fast Electrocardiographic Beats Classification With a Wearable Cardiac Monitor: Development and Validation Study
Authors: Jeon Eunjoo , Oh Kyusam , Kwon Soonhwan , Son HyeongGwan , Yun Yongkeun , Jung Eun-Soo , Kim Min Soo 
Published: March 2020

Background
Electrocardiographic (ECG) monitors have been widely used for diagnosing cardiac arrhythmias for decades. However, accurate analysis of ECG signals is difficult and time-consuming work because large amounts of beats need to be inspected. In order to enhance ECG beat classification, machine learning and deep learning methods have been studied. However, existing studies have limitations in model rigidity, model complexity, and inference speed.

Objective
To classify ECG beats effectively and efficiently, we propose a baseline model with recurrent neural networks (RNNs). Furthermore, we also propose a lightweight model with fused RNN for speeding up the prediction time on central processing units (CPUs).

Methods
We used 48 ECGs from the MIT-BIH (Massachusetts Institute of Technology-Beth Israel Hospital) Arrhythmia Database, and 76 ECGs were collected with S-Patch devices developed by Samsung SDS. We developed both baseline and lightweight models on the MXNet framework. We trained both models on graphics processing units and measured both models’ inference times on CPUs.

Results
Our models achieved overall beat classification accuracies of 99.72% for the baseline model with RNN and 99.80% for the lightweight model with fused RNN. Moreover, our lightweight model reduced the inference time on CPUs without any loss of accuracy. The inference time for the lightweight model for 24-hour ECGs was 3 minutes, which is 5 times faster than the baseline model.

Conclusions
Both our baseline and lightweight models achieved cardiologist-level accuracies. Furthermore, our lightweight model is competitive on CPU-based wearable hardware.
On the Ehrenfest Paradox in the Bohr Atomic Model toward the Quantization of Gravitation
Authors: Putra Fima Ardianto 
Published: March 2020

Ehrenfest Paradox has been studied in the Bohr Atomic Model as the theoretical procedure such a way that we can express the coordinate curvature i.e. gravitational aspect in the electromagnetic coupling constant. The strength of the curvature depends on the principal quantum number which shows that the value of curvature is quantized. For , the value is . The curvature value in the Bohr atomic model can be a standard to measure how strong the curvature of all system are, by comparing them with this value. We also get the understanding that the change of the curvature will manifest the curvature propagation in the form of quantum energy, i.e. . This theory can be considered to enlarge the unification theory between quantum and gravitation. Another consequence of this theory is the quantization of Equivalence Principle.
EVALUATION OF THE PROTECTIVE EFFECT OF GALLIC ACID AGAINST ARSENIC-INDUCED GENOTOXICITY IN HEPG2 CELL LINE
Authors: JOSEPH NIDHYA TERESA , MOKA RAJASEKHAR 
Published: March 2020

Objective: Arsenic has cytotoxic as well as mutagenic effect in human health due to its indirect effect on oxidative stress on the cells. We aimed to find out the effect of gallic acid (GA), a well-known natural antioxidant in ameliorating in heavy metal toxicity.
Methods: MTT assay was performed to determine the cytotoxicity of sodium arsenite (NaAsO2) on HepG2 cells with the cytoprotectant GA at varying concentrations for exposure durations of 6 h, 12 h, and 24 h. Similarly, the alkaline version of the comet assay was performed to investigate the genotoxicity and assessment of oxidative stress of the cells using flow cytometry.
Results: Cells treated with NaAsO2 at various doses spanning a broad range of concentrations (5–500 μM) showed a dose- and time-dependent decrease in cellular viability as observed. However, the effect of the proposed protectant, GA showed an increase in cellular viability in a concentration-dependent manner.
Conclusion: We assessed the cytotoxicity and genotoxicity induced by NaAsO2 to provide insight into the role of GA on arsenic-induced toxicity in liver cells and to shed light on its possible ameliorative effect at low concentrations in a time-dependent manner.
DESIGN, OPTIMIZATION, AND STATISTICAL EVALUATION OF ORAL RECONSTITUTED SUSPENSION OF CLARITHROMYCIN USING ION-EXCHANGE RESINS
Authors: S KOMAL , N HARIKRISHNAN 
Published: March 2020

Objectives: The objective of the present study is taste masking of bitter clarithromycin using Indion 204, Indion 234, and Tulsion 335 as ion-exchange resins, which forms insoluble complexes, inhibiting the drug release in saliva as ion-exchange resins are cross-linked polymers, water-insoluble that contains salt-forming groups in repeating positions on the polymer chain. Drugs that are bitter and cationic get adsorbed onto weak cationic exchange resins of carboxylic acid functionality such as Indion 204, Indion 234, and Tulsion 335 to form non-bitter complexes.
Methods: The drug-resin complex loading process was optimized for the resin content, activation, swelling time, stirring time, influence of pH, and temperature for maximum drug loading and the formed complex was evaluated by differential scanning calorimetry (DSC) to confirm complex formation. The drug-resin complex was also characterized by their micromeritic and rheological properties. These complexes were used to prepare oral reconstituted suspensions and the taste was evaluated. The formulation was evaluated for various parameters such as sedimentation volume, pH, redispersibility, viscosity, drug content, and in vitro drug release.
Results: Acid-activated resins comprising Indion 204, Indion 234, and Tulsion 335 with the drug:resin ratio of 1:2, stirred in a solution of pH 7–8 at 70° for 6 h had a maximum drug loading and masked the bitter taste of clarithromycin. DSC of the drug-resin complex (DRC) revealed that there was interaction leading to complex formation. The drug-resin complex was formulated into suspension formulations (S1-S9) and evaluated. Various parameters were found to be within permissible limits. Formulations S3, S6, and S9 containing 1:2 ratios of the drug-resin complex of Indion 204, Indion 234, and Tulsion 335 revealed maximum taste masking. This was further confirmed by treatment of taste evaluation scores obtained from the volunteers by ANOVA, Dunnett’s multiple comparison test, and Tukey’s multiple comparison test. All the three optimized formulations had a significant difference of p<0.001 when compared to control S10. S6 formulation was widely accepted.
Conclusion: Ion-exchange complexation could efficiently mask the bitter taste of clarithromycin and achieve palatable taste suitable for pediatric use.
ANTIBACTERIAL ACTIVITY AND GAS CHROMATOGRAPHY–MASS SPECTROMETRY STUDIES OF ALGERIAN ATRIPLEX HALIMUS L.
Authors: L ZIANE , M DJELLOULI , A MILOUDI 
Published: March 2020

Objective: The objective of the study was to find out the antibacterial efficacy and identify the main constituents of the essential oil of Atriplex halimus from southwest of Algeria.
Methods: The essential oil from the aerial parts of the endemic plant A. halimus (saltbush in English, qataf in Arabic) collected from the region of Sahara southwest of Algeria was isolated by hydrodistillation and analyzed by gas chromatography–mass spectrometry. Antibacterial potency of essential oil from this plant has been tested against Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), and Bacillus cereus (ATCC11778) by disk diffusion assay.
Results: The essential oil revealed the presence of 14 components, the dominant compounds arecadina-1(10), 4-diene (10.69%), germacrene D (9.79%), octane (9.37%), pelargonaldehyde (9.06%), 3-Furancarboxaldehyde (6.87%), β-pinene (2.6%), camphene (2.59%), and myrcene (2.10%). The essential oil exhibits very effective antimicrobial activity using disk diffusion assay method with minimum inhibitory concentration ranging from 0.82 μl/ml to 2.4525 μl/ml.
Conclusions: This result showed that this native plant may be a good candidate for further biological and pharmacological investigations.
THE EFFECTIVENESS OF USING SIWAK TOOTHPASTE ON PLAQUE ACCUMULATION IN FIXED ORTHODONTIC APPLIANCES USERS’
Authors: HALIM HIMAWAN , AYULIA SALSABILA TALITHA 
Published: March 2020

Objective: The objective of the study was to determine the ability of toothpaste containing Salvadora persica (Siwak) to reduce the accumulation of dirt in the oral cavity compared to ordinary toothpaste users in fixed orthodontic users.
Methods: It was conducted on 40 subjects, divided into two groups of A and B. Group A uses Siwak, while Group B uses ordinary toothpaste. The research subjects were students that utilized fixed appliances for at least 6 months and without periodontal disease. Data were obtained by measuring the plaque level before and after using the toothpaste.
Results: A significant relationship between the use of Siwak and ordinary toothpaste by reducing its accumulation in patients using fixed orthodontic appliances and a Chi-square statistical test value of 0.018.
Conclusion: The use of Siwak is more effective in reducing plaque accumulation in fixed orthodontic appliance users compared to ordinary toothpaste.
ANTIOXIDATIVE AND FREE RADICAL SCAVENGING POTENTIALS OF HABENARIA PECTINATA
Authors: KAUR CHARANJIT , KUMAR RAJESH , SINGH GURVINDER , MOHAN CHANDER 
Published: March 2020

Objective: This study was designed to evaluate the antioxidative potential of tubers of Habenaria pectinata.
Methods: The tubers of H. pectinata were extracted using hexane, ethyl acetate, methanol, and water as solvents. The anti-oxidant potential of extracts was evaluated using free radical scavenging and reducing power assays. The most active methanolic extract was then fractionated into four fractions using the above-mentioned solvents.
Results: The phenol and flavonoid content was found to be maximum in the methanol extracts. All the extracts and fractions showed significant levels of antioxidant activity except hexane extract.
Conclusion: The tubers of H. pectinata were found to possess a significant antioxidant potential and can be explored further for isolation and preclinical investigation for the ailment of various diseased states and disorders.
La Messaline Française y L'Histoire de Dom Bougre, portier des Chartreux: dos ejemplos de literatura erótica
Authors: Ruiz García Claudia 
Published: March 2020

En este ensayo se revisan dos novelas francesas del siglo XVIII, La Messaline Française y L'Histoire de Dom Bougre, portier des Chartreux, que ilustran algunos aspectos de la representación de la sexualidad y al mismo tiempo denuncian a las instituciones religiosas y políticas —la iglesia y la monarquía— que sustentan al antiguo régimen.
La écfrasis de la tienda del rey Adrastro, en el Roman de Thèbes: estructura, estrategias retóricas e intertextualidad
Authors: Altamirano Meza Gerardo 
Published: March 2020

Uno de los motivos ecfrásticos más frecuentes en la literatura medieval es el de la tienda historiada. Es decir, la descripción de elementos figurativos, dibujados o bordados que se hallan en los paños de una tienda militar, generalmente de carácter regio. En este escrito se analiza la descripción o écfrasis de la tienda de Adrastro que aparece en el Roman de Thèbes y que, presumiblemente, es el arquetipo de otras descripciones medievales, como la tienda de Alejandro, que se describe en el Libro de Alexandre, y la tienda de Don Amor, descrita en el Libro de Buen Amor. A lo largo del ensayo se evidencia la manera en la que el autor estructura el pasaje, algunas estrategias retóricas (como la enumeratio, la aposiopesis y la hipérbole) y, asimismo, se realiza un diálogo hipertextual, tanto con otras obras medievales como con las fuentes clásicas.
El Navfrágio da nao S. Alberto, e itinerário da gente que delle se salvov, de João Baptista Lavanha: los paratextos de 1597 y los de 1736
Authors: Miranda Aguilar Alma Delia 
Published: March 2020

La redacción de paratextos como títulos, portadas y dedicatorias entre los siglos XVI y XVIII tenía implicaciones políticas de peso. Éstos mostraban la dependencia de los autores en relación con personajes poderosos, como monarcas y miembros de la nobleza. Durante este periodo, modificar los paratextos implicaba la transformación de los objetivos del autor. En este artículo se comparan e interpretan los paratextos de la edición de 1597 del Navfrágio da nao S. Alberto, e itinerario da gente que delle se salvov, del cosmógrafo mayor João Baptista Lavanha, y los de la edición de 1736, incluida en la antología História trágico-marítima, de Bernardo Gomes de Brito. Mientras Lavanha dedicó su relación al futuro Felipe III, Brito dedicó su compilación al rey D. João V, miembro de la dinastía que restauró la monarquía en Portugal.
La teología liberadora de Toni Morrison frente a las religiones institucionales como opción ética de sanación espiritual
Authors: Villegas Salas Lilia Irlanda 
Published: March 2020

A partir del estudio de un personaje secundario de Beloved (1987) se demuestra la exactitud de la construcción historiográfica en la novelística estadounidense contemporánea de la Premio Nobel 1993, Toni Morrison, que tiene como tema la esclavitud. La investigación se amplía retrospectivamente de los siglos xix al xvii al incluir A Mercy (Morrison, 2008) en un análisis contrastivo basado en la lectura meticulosa realizada desde la crítica ética. El punto de interés central es la génesis y evolución temprana de la Iglesia afroamericana como institución propia de un grupo étnico particular, emparentada con los procesos de gestación de libertad de los afroestadounidenses y la lucha por los derechos civiles, con un fuerte énfasis en la participación femenina. El surgimiento de una teología afroamericana es validado como una ruta de sanación espiritual viable y susceptible de ser reconocida en nuestra época.
Imagen recobrada: Barthes como lector de Proust
Authors: Quiroz Bustamante Dulce María Griselda 
Published: March 2020

Este texto aborda la relación intertextual entre Marcel Proust y Roland Barthes. En La cámara lúcida, Barthes hace referencia a En busca del tiempo perdido. Mientras Proust trabaja con imágenes mentales, Barthes se dedica a las imágenes fotográficas. En ambos casos, buscan recuperar el tiempo y el instante perdidos. Para Barthes, la fotografía es inseparable de la muerte y de una ausencia irremediable; en el caso de Proust, la memoria compensa la amenaza del olvido de la muerte, sin dejar de ser experiencia de duelo. La fotografía se vuelve catastrófica al revelar el recuerdo de la persona que ya no está. El acontecimiento que sucedió una única vez está de nuevo presente, en una forma de nombrar la ausencia. Tanto la fotografía como el recuerdo llevan la carga de la finitud, la presencia irremediable de la muerte.
SISTEMAS ADESIVOS
Authors: Spezzia Sérgio 
Published: March 2020

Resumo Sistemas adesivos constam do agrupamento de monômeros resinosos dotados de diferenciadas características, bem como são compostos por solventes orgânicos e diluentes. Almeja-se com o recurso da Odontologia Restauradora obter-se adesividade dos materiais odontológicos resinosos aos dentes por intermédio do uso dos sistemas adesivos. O objetivo deste artigo foi averiguar acerca da utilização dos sistemas adesivos nos procedimentos odontológicos. Dispõem-se de vários materiais odontológicos para uso, englobando a categoria dos sistemas adesivos, concomitantemente existem disponibilizadas técnicas para utilização voltadas particularmente a cada material. O selecionamento de determinado sistema adesivo para emprego clínico, visando proceder ao seu uso satisfatoriamente deve ocorrer de forma consciente e deve basear-se nas características apresentadas por cada material. Pode-se classificar os sistemas adesivos em convencionais ou etch-and-rinse e em autocondicionantes ou self-etch. Adesivos multimodais ou universais constituem uma outra categoria disponibilizada para uso, que possui a propriedade de poder ser empregado, fazendo-se uso da técnica autocondicionante ou convencional. A escolha correta do sistema adesivo para utilização clínica, levando em consideração as particularidades do elemento dental que será restaurado tende a propiciar desfecho restaurador satisfatório. Palavras-chave: Adesividade. Adesivos. Esmalte Dentário. Dentina. Keywords: Adhesiveness. Adhesives. Dental Enamel. Dentin.
LUXAÇÃO LATERAL E INTRUSIVA ASSOCIADA A FRATURA CORONÁRIA EM DENTES PERMANENTES DE PACIENTE PEDIÁTRICO: RELATO DE CASO CLÍNICO
Authors: Torres da Silva Madelaine 
Published: March 2020

RESUMO As lesões dentárias traumáticas em pacientes pediátricos são condições relativamente comuns na Odontologia. A avaliação e o diagnóstico corretos são determinantes para o sucesso do tratamento a longo prazo. Este relato descreve o caso de uma paciente pediátrica que sofreu uma queda da própria altura que ocasionou luxação lateral associada a luxação intrusiva, além de fratura da tábua óssea alveolar vestibular e fratura coronária dos elementos envolvidos, exigindo um manejo clínico delicado e efetivo. Em dois anos de acompanhamento a paciente não apresentou nenhuma complicação, exibindo resultados clínicos satisfatórios com a conduta terapêutica aplicada. Palavras-chave: Traumatismo dentário, emergências, osso, dentes, periodontal. ABSTRACTTraumatic dental injuries in pediatric patients are relatively common conditions in dentistry. Correct medical evaluation and diagnosis are critical to long-term treatment success. This report describes the case of a pediatric patient who suffered a fall from his own height that caused lateral dislocation associated with intrusive dislocation, in addition to fracture of the vestibular alveolar bone plate and coronary fracture of the involved elements requiring a delicate and effective clinical management.In two years of follow-up, the patient did not present any complications, showing satisfactory clinical results with the applied therapeutic approach. Key words: Dental trauma, emergencies, bone, teeth, periodontal.
Risk of Ipsilateral Reamputation Following an Incident Toe Amputation Among U.S. Military Veterans With Diabetes, 2005–2016
Authors: Littman Alyson J. , Tseng Chin-Lin , Timmons Andrew , Moore Kathryn , Landry Gregory , Czerniecki Joseph M. , Robbins Jeffrey , Boyko Edward J. 
Published: March 2020

OBJECTIVE
To assess whether the risk of subsequent lower-limb amputations and death following an initial toe amputation among individuals with diabetes has changed over time and varies by demographic characteristics and geographic region.

RESEARCH DESIGN AND METHODS
Using Veterans Health Administration (VHA) electronic medical records from 1 October 2004 to 30 September 2016, we determined risk of subsequent ipsilateral minor and major amputation within 1 year after an initial toe/ray amputation among veterans with diabetes. To assess changes in the annual rate of subsequent amputation over time, we estimated age-adjusted incidence of minor and major subsequent ipsilateral amputation for each year, separately for African Americans (AAs) and whites. Geographic variation was assessed across VHA markets (n = 89) using log-linear Poisson regression models adjusting for age and ethnoracial category.

RESULTS
Among 17,786 individuals who had an initial toe amputation, 34% had another amputation on the same limb within 1 year, including 10% who had a major ipsilateral amputation. Median time to subsequent ipsilateral amputation (minor or major) was 36 days. One-year risk of subsequent major amputation decreased over time, but risk of subsequent minor amputation did not. Risk of subsequent major ipsilateral amputation was higher in AAs than whites. After adjusting for age and ethnoracial category, 1-year risk of major subsequent amputation varied fivefold across VHA markets.

CONCLUSIONS
Nearly one-third of individuals require reamputation following an initial toe amputation, although risks of subsequent major ipsilateral amputation have decreased over time. Nevertheless, risks remain particularly high for AAs and vary substantially geographically.
Deklaration för öppen vetenskap och forskning 2020–2025
Authors: Avoimen tieteen ja tutkimuksen koordinaatio  
Published: March 2020

Deklarationen för öppen vetenskap och forskning är det finländska forskarsamfundets gemensamma vision. Enligt visionen skall öppen vetenskap och forskning vara en del av forskarnas vardag, och öppenhet ska stödja både genomslagskraften av de olika slutprodukter som forskningen resulterar i och forskningens kvalitet. Det finländska forskarsamfundet skall också vara en internationell föregångare inom öppen vetenskap och forskning.
Vägen till förverkligande av visionen beskrivs i missionen för öppen vetenskap och forskning. Missionen är att:

främja öppenhet som ett grundläggande värde inom forskarsamfundets hela verksamhet,
förstärka samhällets bildningsnivå och innovationsverksamhet och
förbättra kvaliteten på vetenskaplig och konstnärlig forskning och de läromedel som grundar sig på dem samt ett smidigt utbyte och genomslag av forskningsoutput i hela samhället, mellan forskare och forskargrupper, mellan forskningsområden, mellan forskning och utbildning, mellan forskare och företag, den offentliga sektorn samt tredje sektorn och mellan forskare och samhälleliga beslutsfattare samt medborgare.
ГИПЕРТЕХНОЛОГИЧНОЕ РАЗВИТИЕ РОССИИ
Authors: Самаруха Алексей 
Published: March 2020

Проведен обзор общемировой ситуации по вопросам доступности для разных групп человеческого общества высоких технологий в различных сферах жизнедеятельности. Дана общая оценка деятельности крупных корпораций в сфере получения и передачи знаний и технологий. Даны рекомендации по формированию нового подхода к
обеспечению свободного общественного доступа к передовым знаниям и технологиям, и гипертехнологичному развитию России. Предложено установить международную уголовную ответственность за сокрытие передовых технологий и научных достижений, за распространение заведомо морально отсталых технологий, а так же, что не менее важно, за дезинформирование и искажение фактической картины исторических и современных событий