bluuebunny/crossref_metadata_2025_split huggingface dataset:
PHARMACOGNOSTICAL STANDARDIZATION AND HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY FINGERPRINT OF ROOTS OF ANTHOCEPHALUS CADAMBA
Authors: KAVERIPAKAM SAISRUTHI  , ADIKAY SREEDEVI  
Published: October 2019

Objective: Anthocephalus cadamba is a traditional medicinal plant which is valued for its benefits in the management of various ailments. The current study was aimed to provide requisite pharmacognostic details and high-performance thin-layer chromatography (HPTLC) fingerprint profile for the roots of A. cadamba.
Methods: Pharmacognostic evaluation included examination of morphological and microscopic characters, physicochemical analysis, fluorescence study, preliminary phytochemical analysis, and HPTLC fingerprint.
Results: The microscopic studies showed the presence of thick periderm, cortical zone, secondary phloem, and secondary xylem. Microscopic examination of root powder showed abundant fibers and vessel elements. The physicochemical analysis of root powder helped in the assessment of quality control parameters. Fluorescence analysis of root powder imparted characteristic colors on the treatment of the powder with different reagents. Preliminary phytochemical studies reported the presence of alkaloids, saponins, flavonoids, steroids, terpenoids, glycosides, tannins, and other phenolic compounds. The developed qualitative densitometric HPTLC fingerprint can be used as an identifying biochemical marker for ethanol extract of the roots of A. cadamba.
Conclusion: The present study provides the information with respect to identification and authentication of crude drug and serves as a reference point for the proper identification of roots of this medicinal plant, thereby contributing to the scientific world of research.
MOLECULAR DOCKING OF HYRTIMOMINE A-K FROM MARINE SPONGE HYRTIOS SPP. AS ANTICANCER TARGET OF PHOSPHOINOSITIDE-DEPENDENT KINASE 1
Authors: RAMA ADIGA  
Published: October 2019

Objective: The hyrtimomine A-K class of indole-based compounds extracted from Hyrtios spp. of sponges from the sea has not been studied for their anticancer properties. Phosphoinositide-dependent kinase 1 (PDK1) is a master regulator of many types of cancer. Compounds currently targeting PDK1 are currently of poor specificity and solubility. Hence, molecular docking to look for new compounds inhibiting PDK1 from the marine environment was carried out.
Methods: Target selection for ligands hyrtimomine A-K was done using PharmMapper tool. Molecular docking was done using iGEMDOCK 2.1, a generic evolutionary method of docking. Site moiety mapping was done in SimMap to extract the anchor preference of the top hits. Comparison of ligand binding energies, pharmacokinetic properties with lead compound BX-517 was carried out.
Results: Hyrtimomine B, C, D, and G were top hits using iGEMDOCK. The highest score was obtained for hyrtimomine C. Van der Waals interaction at T222 and V96 and hydrogen bond interaction at K111 determined pocket stability. The solubility properties of the compound showed higher score for hyrtimomine C. The conserved features of hyrtimomine C were then compared with the crystal structure of lead compound (BX-517, which was not developed further due to poor solubility and bioavailability). The pharmacokinetic properties of hyrtimomine C were superior to BX-517 and had better solubility and drug-likeness score, hence, may be a candidate structure for drug development.
Conclusion: The unique azapeno indole structure of hyrtimomine C highlighted the mode of binding and residues in binding site.
COMPARISON BETWEEN DIETARY INTAKE AND AGE IN RELATION TO BODY MASS INDEX AMONG POLYCYSTIC OVARIAN SYNDROME WOMEN – A CASE–CONTROL STUDY
Authors: BRINDHA G  , MADHANSHANKAR SR  
Published: October 2019

Objective: Polycystic ovarian syndrome (PCOS) is the most prevalent endocrine disorder, affecting up to 6.8% of women at their prime reproductive age. The aim of the study is to prove the interrelationship between food patterns, age, and anthropometric measurements in relation with body mass index (BMI) among PCOS women and control participants.
Methods: The study was performed among 80 PCOS women and control participants according to the Rotterdam criteria. The data were collected through questionnaire which included age, socioeconomic data, anthropometric details, and food pattern, and the values were analyzed using Minitab 17 by Box plot method for graphical representation. The comparative analysis between age group and BMI was done by ANOVA.
Results: The results showed that there was significant relationship between inappropriate food pattern and PCOS women showing higher frequency of ±8.30 among age group (19-24 years) with an average BMI of 31.6 kg/m2. The unhealthy diet along with BMI was correlated with the visual examination of presence of hirsutism. From the ANOVA analysis, it was significantly proved with probability (p=0.002); there was stronger association between lifestyle modifications and PCOS. This is the first association study to correlate between dietary habitat and age group with BMI among South Indian in Coimbatore district.
Conclusion: From the results obtained, it is necessary to create awareness for women and girls about the ill effects of lifestyle modifications, unhealthy food pattern, and lack of physical activity which lead hormonal and metabolic changes.
DESIGN, PREPARATION, AND EVALUATION OF SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM OF BAMBUTEROL HYDROCHLORIDE
Authors: SACHIN SAGGAR  , ASHUTOSH UPADHAYAY  , MANISH GOSWAMI  
Published: October 2019

Objective: The self-micro-emulsifying drug delivery system (SMEDDS) of bambuterol hydrochloride was designed, prepared, and evaluated to overcome the problem of poor bioavailability.
Methods: The designing of the formulation included the selection of oil phase, surfactant, and cosolvent/cosurfactant based on the saturated solubility studies. Psuedoternary phase diagram was constructed using aqueous titration method, to identify the self-emulsifying region. Different ratios of the selected surfactant and cosolvent/cosurfactant (Smix) were also studied and used to construct the ternary phase diagram. The prepared formulations of the SMEDDS were evaluated for drug content, morphology, globule size, robustness to dilution, emulsification time, optical clarity, and stability.
Results: The formulation containing 10 mg bambuterol hydrochloride, triacetin (12.50% w/w), Tween 80 (43.75% w/w), and ethanol (43.75% w/w) was concluded to be optimized. The optimized SMEDDS not only showed optimum globule size, zeta potential, and drug content but was also found to be robust to dilution, formed emulsion spontaneously, and was stable. The optimized SMEDDS showed increased permeability of the drug across the intestinal membrane in ex vivo studies.
Conclusion: The results suggest that bambuterol hydrochloride can be formulated as self-microemulsifying drug delivery system, and further, SMEDDS can be used to improve the oral bioavailability of bambuterol hydrochloride.
CONDUCTOMETRIC DETERMINATION OF LOSARTAN POTASSIUM USING PHOSPHOTUNGSTIC ACID, BROMOCRESOL PURPLE, MERCURY (II) CHLORIDE, AND CUPRIC CHLORIDE AS REAGENTS
Authors: ABDEL-MONEM AFAF ABOUL-KHIER , AHMED BAHGAT EMAN 
Published: October 2019

Objectives: In the current study a simple and precise four conductometric methods were introduced for determination of Losartan Potassium (LK) in pure form and tablets.
Methods: Method A is based on titration of LK using phosphotungstic acid, method B is based on titration of LK using bromocresol purple dye, method C is based on titration of LK using mercury (II) chloride, and method D is based on titration of LK using cupric chloride.
Results: LK was found to be linear in the concentration range of 3–20 mg/mL for all methods except for method C, the concentration range was 1–12 mg/mL. The obtained percentage recoveries for the four methods ranged from 99.69% to 100.53%; the relative standard deviation values were not exceeding two for all methods.
Conclusion: The suggested methods were successfully applied for the determination of LK in tablets, with results in close agreement at 95% confidence level with those obtained using the reference spectrophotometric method.
La protección de los datos personales en el registro de dispositivos de almacenamiento masivo de información
Authors: Pérez Estrada Miren Josune 
Published: October 2019

El objeto de este trabajo es poner de manifiesto los problemas que plantea la investigación criminal cuando se analizan instrumentos tecnológicos en la averiguación del delito. En concreto, se estudia cómo afecta al derecho fundamental a la protección de los datos personales la prueba que se ha obtenido, con motivo de la investigación criminal, mediante el análisis de los datos contenidos en los dispositivos de almacenamiento masivo de la información. Se analiza el tratamiento jurídico que se da a la protección de los datos personales como parte de lo que se ha venido a denominar por la jurisprudencia “protección del entorno virtual” y las consecuencias jurídicas que tiene en el proceso penal. En definitiva, se quiere advertir cuáles son los efectos que tiene en el proceso penal la prueba que se ha obtenido vulnerando el derecho fundamental a la protección de los datos personales.
ANALISIS KINERJA DAN STRATEGI PENGEMBANGAN UMKM ALAS KAKI DI DESA PAGELARAN
Authors: Hidayah Ulul , Mulatsih Sri , Purnamadewi Yeti Lis 
Published: October 2019

<p><em>Village economic development should be focused on local potential. Each village has different potentials, one of which is Pagelaran Village which has local potential in footwear business development. In developing the footwear sector as the center of village economic growth, it is necessary to identify the problems and business needs. The Impotence Performance Analysis (IPA) method is carried out to measure the gap between the level of conditions and the level of importance of the variables in the development of a footwear business. From the results of the study concluded that the problems in the development of footwear businesses are limited capital, high raw material prices, decreasing number of workers, low selling prices, poor business management, lack of roles of craftsmen and government groups in business development. Results of the gap analysis indicate that the variable that has the largest gap is the variable role of the government in business development with a performance value of 33%. The village government through village community empowerment policies and programs that are very much needed by footwear entrepreneurs. To increase the footwear business, the village government needs to establish BUMDes with the main program, providing capital loans, procuring raw materials, joint marketing, and training in business management skills.</em></p><p> </p><p>Pembangunan ekonomi desa dapat dicapai dengan memperhatikan potensi lokal. Setiap desa memiliki potensi yang berbeda-beda, salah satunya Desa Pagelaran yang memiliki potensi lokal di bidang pengembangan usaha alas kaki. Dalam mengembangkan sektor alas kaki sebagai pusat pertumbuhan ekonomi desa maka perlu dikakukan identifikasi permasalah dan kebutuhan usaha. Sehingga dapat dirumuskan strategi pengembangan usaha alas kaki sebagai potensi lokal Desa Pagelaran. Metode Impotrance Performance Analysis (IPA) dilakukan untuk mengukur gap antara tingkat kondisi dan tingkkat kepentingan variabel-variabel pengembangan usaha alas kaki. Dari hasil penelitian disimpulkan bahwa masalah-masalah yang dihadapi dalam pengembangan usaha alas kaki adalah ketersediaan modal usaha, harga bahan baku yang tinggi, jumlah tenaga kerja semakin berkurang, buruknya manajemen usaha, tidakadanya peran kelompok pengrajin dan pemerintah dalam pengembangan usaha. Sedangkan hasil dari analisis gap menunjukkan bahwa variabel yang memiliki gap terbesar adalah variabel peran pemerintah dalam pengembangan usaha dengan nilai 2,96. Hal ini menunjukkan kehadiran pemerintah desa melalui kebijakan dan program pemberdayaan masyarakat desa sangat dibutuh oleh pengusaha alas kaki. Untuk meningkatkan usaha alas kaki pemerintah desa perlu membentuk BUMDes dengan program utama, pemberian pinjaman modal, pengadaan bahan baku, pemasaran bersama, dan pelatihan keterampilan manajemen usaha.</p>
Daya Antihiperglikemia Yoghurt Pada Mencit Putih Jantan
Authors: Dewi Irene Puspa , Septriani Roza , Verawaty Verawaty , Mulyani Dwi 
Published: October 2019

<p><em>Research has been conducted on the antihyperglycemic of yogurt in male white mice. Yogurt contains probiotics that have a positive effect on both type 1 and types 2 diabetes mellitus. Yogurt is given for 3 weeks at a dose of 200 grams / Kg BW / day and 400 grams / Kg BW / day to mice that have been alloxan-induced. As a comparison, a positive control group was created, the alloxan-induced mice group, but not given yogurt and a negative control group, the mice group without any treatment. After 3 weeks of treatment with yogurt, it was found that there was a significant difference between the average blood glucose levels in the mice of the 200 grams/ Kg BW group and the 400 grams / Kg BW dose with the positive control group. From the data on the percentage increase in blood glucose levels of mice, it is known that by giving yogurt for 3 weeks, reducing the high percentage of increase in blood glucose levels in mice. From these data, it can be concluded that the administration of yogurt with a dose of 200 grams / Kg / day and 400 grams / Kg / day can help reduce blood glucose levels in alloxan-induced mice.</em></p><p> </p><p><em>Telah dilakukan penelitian mengenai daya antihiperglikemia yogurt pada mencit putih jantan. Yogurt mengandung probiotik yang memberikan pengaruh positif terhadap diabetes mellitus baik tipe 1 maupun tipe 2. Yogurt diberikan selama 3 minggu dengan dosis 200/Kg BB/hari dan 400 gram/Kg BB/hari kepada mencit yang telah diinduksi aloksan. Sebagai pembanding dibuat kelompok kontrol positif yaitu kelompok mencit yang diinduksi aloksan, namun tidak diberi yogurt dan kelompok kontrol negatif, yaitu kelompok mencit tanpa perlakuan apapun. Setelah 3 minggu perlakuan dengan yogurt, didapatkan hasil bahwa terdapat perbedaan bermakna antara rata-rata kadar glukosa darah mencit kelompok dosis 200 gram/Kg BB dan dosis 400 gram/Kg BB dengan kelompok kontrol postif. Dari data persentase kenaikan kadar glukosa darah mencit, diketahui bahwa dengan pemberian yogurt selama 3 minggu, mengurangi tingginya persentase kenaikan kadar glukosa darah mencit.dari data-data tersebut, dapat disimpulkan bahwa pemberian yogurt dengan dosis 200 gram/Kg BB/hari dan 400 gram/Kg BB/hari dapat membantu menurunkan kadar glukosa darah mencit yang diinduksi aloksan.</em></p>
Application of Co-Production in Waste Management Through Waste Banks Program in Batu City
Authors: Irkham Sulung Satriyo , Kamil Muhammad , H Saiman 
Published: October 2019

The problem of waste in Batu City can threaten tourism sector in this city. The Waste Management System Program is held by the Environment Agency (DLH) Batu City seems to be unable to access waste problems in the upstream sector, particularly household waste from residential settlements. This lack capacity of the program followed up by DLH by organizing a waste bank program through the establishment of the Community Waste Bank (KBS) Kartini Sejati which coordinated around 60 waste banks in Batu City to be involved in waste management.This study aims to explain the involvement of KBS Kartini Sejati in waste management in co-production and the obstacles faced by it. The concept of co-production refer to an alternative concept in the implementation of public services where implementation focuses on the dominant role of the community, while the government or other parties such as the private sector are only facilitators. This research use qualitative method by utilizing data from observations, interviews and documentation. The results of this study indicate that KBS Kartini Sejati in several of its activities which include training in waste management, waste management, and "Sapu Bersih Sanpah Nyemplung Kali" (Saberpungli) have applied the principles of co-production. It is due to those activities have implemented six co-production principles, namely the development of community capacity, mutually beneficial relationships between actors, network development, the government as a facilitator and catalyst, and the community as an important asset in implementing services. However, in its implementation, the waste bank program still has several obstacles such as the limitations of the budgetary resources, the decreasing level of public awareness to be active in waste banks, and the lack of innovation in waste managementKeywords: Co-production; waste management, waste bank
Health Related-Quality of Life in CKD and Dialysis Patients in Asian Countries : A Systematic Review
Authors: Anjarwati Aan 
Published: October 2019

ABSTRACT
Introduction: Chronic Kidney Disease (CKD) and Chronic dialysis has a great impact on patients health-related quality of life (HRQOL). The impacts are about the morbidity, mortality, and the survival rate of the dialysis therapy. We focused this systematic review in Asian countries.
Methods: Systematic Review with PRISMA method retrieved from online database such as PubMed, Wiley and ProQuest using a keyword “Health Related-Quality Life (HRQOL)”, “Chronic Kidney Disease (CKD) patient OR ESRD (End Stage Renal Disease), CKD with Hemodialysis OR CKD dialysis at Asian Country”. The end of this search we got 10 journals.
Results: The measurement HRQOL in CKD or dyalisis patients such EQ-5D and Kidney Disease Quality of Life (KDQOL). There are 4 country used KDQL (Korea, China, India, Singapore and Indonesia). The result show HRQOL in CKD patients has declined when the level of CKD increased especially when the amount of albumin high and the level of hemoglobin decline. HRQOL in dialysis patient has lower depressive mood in planned dialysis group than unplanned dialysis. There are no difference in KDCS, PCS, or MCS scores between patients treated by hemodialysis and CAPD. They also got 5 more years when choose dialysis (Hemodialysis).
Conclusion: Health related quality of life (HRQOL) related with progressive of CKD level. The level that should pay attention is CKD level 3 where HRQOL can decreased. When the patients routine dialysis (CAPD or hemodialysis) used concern about the medicine (such erythropoietin, routine medicine) and the laboratory (albumin and hemoglobin). The more progressive level of CKD the lower of HRQOL.
Keywords: Health Related Quality of Life (HQOL), CKD (Chronic Kidney Disease), Dialysis, Hemodialysis, Continuous Ambulatory Peritoneal Dialysis (CAPD).
DE LA GLOBALIZACION A LA TRANSRELOCALIZACIÓN DE LO RELIGIOSO
Authors: Castellanos Rennee de La Torre 
Published: October 2019

El presente artículo propone abandonar el concepto de globalización cultural para,
como ya lo había sugerido Robertson, atender de mejor manera los reacomodos de lo local
en lo global. La autora descompone el proceso de la glocalización en tres fases dialécticas: 1)
la deslocalización de la cultrua; 2) la translocalización (transnacionalizaciòn de la culturas),
y 3) la relocalización de las culturas globales. Tras describir seis procesos contemporáneos de
glocalización de las religiosidades que transforman los sentidos culturales y funcionales de
las prácticas tradicionales, caracteriza la glocalización como un fenómeno multidireccional
cuyos principales efectos no sólo son desanclar o desterrritorializar la cultura, sino sobre todo
la reterritorialización de las sociedades y sus producciones culturales. Se subraya la relevancia
que hoy en día está teniendo la religión, en especial aquella valorada como tradicional, étnica
o ancestral, como fuente de anclaje de los imaginarios globales y de enraizamiento de las
movilidades humanas. Este ensayo concluye haciendo un llamado a una nueva antropología
que sin descuidar las monografías densas de las tradiciones locales atienda a su vez las realidades
multisituadas que la transversalizan y conectan con fenómenos globales
O RACIONALISMO CRISTÃO EM CABO-VERDE, OU OS ESPíRITOS SEM FRONTEIRAS
Authors: Plaideau Charlotte 
Published: October 2019

O racionalismo cristão é uma doutrina flosófca de caráter espiritualista, fundada
em Santos (Brasil), em 1910. Hoje, porém, ela é proporcionalmente bem mais desenvolvida
em Cabo Verde, assim como na diáspora cabo-verdiana, através da qual se está expandindo
pelo mundo inteiro. Este artigo tenta entender, no contexto das ilhas e no funcionamento
híbrido da doutrina, porque ele faz particularmente eco aos Cabo-verdianos, nativos e
migrantes. Propomos a hipótese de que o sucesso da sua consolidação e transnacionalização
resulta da tensão que sua prática atualiza entre uma aspiração ao racionalismo ocidental e
uma ancoragem espiritualista inconfundível.
APONTAMENTOS SOBRE FORMAS ALTERNATIVAS DE REAFRICANIZAÇÃO EM TERREIROS DE BATUQUE NO RIO GRANDE DO SUL, ARGENTINA E URUGUAI
Authors: De Bem Daniel Francisco 
Published: October 2019

Nas últimas décadas tem ampliado a importância e visibilidade do processo de
reafricanização entre populações negras e grupos com práticas culturais de ascendência
africana. Entre os adeptos das religiões de matriz ou presença africana, não é diferente. A
partir do estudo do sistema religioso batuqueiro em uma escala transnacional, este texto
versa sobre algumas formas alternativas com as quais afro-religiosos do Rio Grande do
Sul, Argentina e Uruguai têm se inserido nesse processo tanto no campo religioso quanto
político, em busca da purifcação de seus rituais e de uma participação nas respectivas
esferas públicas locais e nacionais que permita a visibilidade, legitimação e respeito de uma
religiosidade singularidade pela sua referência a uma origem e uma ontologia relativas às
etnias negras e a áfrica.
TRANSNACIONALIZAÇÃO RELIGIOSA NO CONE-SUL: UMA COMPARAÇÃO ENTRE PENTECOSTAIS E AFRO-RELIGIOSOS
Authors: Oro Ari Pedro 
Published: October 2019

O texto procura efetuar uma aproximação comparativa das transnacionalizações
pentecostal e afro-religiosa nos países do Cone-Sul. Propõe uma tipologia de modelos de
transnacionalização, os quais não ocorrem através dos aparelhos de Estado mas, antes, são
baseados em redes transnacionais, divididas entre aquelas em que as instituições seriam as
“âncoras” e os “nós” e outras em que os indivíduos cumpririam tais funções. Além disso, o
texto recupera elementos recorrentes no processo de transnacionalização envolvendo os dois
segmentos religiosos, com destaque para a afrmação da idéia de nação e das identidades
nacionais; a busca do poder, do saber e da elevação de status como elementos motivadores
para a inserção nas redes transnacionais; a importância da Internet como ferramenta
privilegiada na operacionalização das redes; e a mediação musical como um importante
reforço da transnacionalização religiosa.
EVANGÉLICOS NO CÁRCERE: REPRESENTAÇÃO DE UM PAPEL DESACREDITADO
Authors: Dias Camila Caldeira Nunes 
Published: October 2019

Este artigo pretende abordar a questão da religiosidade evangélica
dentro da prisão observando, de um lado, as transformações produzidas em
decorrência da conversão religiosa e, de outro, compreender o lugar e a posição
que este grupo ocupa no sistema social prisional. Para isso, analisamos as relações
estabelecidas entre os evangélicos e a massa carcerária, marcada por tensões e
ambigüidades, que conformam e definem as características deste grupo religioso
dentro da prisão: a ilegitimidade e o descrédito. As interações entre evangélicos
e massa carcerária estão constantemente ameaçadas de ruptura, o que torna
essa realidade social extremamente precária.