bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concentrations of Antidepressants, Antipsychotics, and Benzodiazepines in Hair Samples from Postmortem Cases
Authors: Methling Maximilian , Krumbiegel Franziska , Alameri Ayesha , Hartwig Sven , Parr Maria K. , Tsokos Michael 
Published: February 2020

AbstractCertain postmortem case constellations require intensive investigation of the pattern of drug use over a long period before death. Hair analysis of illicit drugs has been investigated intensively over past decades, but there is a lack of comprehensive data on hair concentrations for antidepressants, antipsychotics, and benzodiazepines. This study aimed to obtain data for these substances. A LC-MS/MS method was developed and validated for detection of 52 antidepressants, antipsychotics, benzodiazepines, and metabolites in hair. Hair samples from 442 postmortem cases at the Institute of Legal Medicine of the Charité-University Medicine Berlin were analyzed. Postmortem hair concentrations of 49 analytes were obtained in 420 of the cases. Hair sample segmentation was possible in 258 cases, and the segments were compared to see if the concentrations decreased or increased. Descriptive statistical data are presented for the segmented and non-segmented cases combined (n = 420) and only the segmented cases (n = 258). An overview of published data for the target substances in hair is given. Metabolite/parent drug ratios were investigated for 10 metabolite/parent drug pairs. Cases were identified that had positive findings in hair, blood, urine, and organ tissue. The comprehensive data on postmortem hair concentrations for antidepressants, antipsychotics, and benzodiazepines may help other investigators in their casework. Postmortem hair analysis results provide valuable information on the drug intake history before death. Pattern changes can indicate if drug intake stopped or increased before death. Results should be interpreted carefully and preferably include segmental analysis and metabolite/parent drug ratios to exclude possible contamination.
Screening of long non‐coding RNAs markers in plasma of children with chronic gastritis
Authors: Gu Zhen , Shen Hua‐Qin , Fu Pei‐Hua , Chen Mei 
Published: February 2020

AbstractObjectiveThe study aimed to detect and analyze long non‐coding RNAs (lncRNAs) in plasma of children diagnosed with chronic gastritis, and to explore its biological functions and involved signaling pathways.MethodsThe plasma samples were collected from six children that were diagnosed with chronic gastritis by physical examination, gastroscopy, and pathological examination and six healthy children. The plasma samples were assayed for determining the expression profiles of lncRNA based upon the gen chip detection. The specific expression of lcnRNA in plasma of children with chronic gastritis was analyzed and its biological functions were speculated.ResultsFive lncRNAs (RP11‐697M17.1, RP11‐388M20.9, AFAP1‐AS1, BC062758, and XLOC001406) were significantly up‐regulated, and five lncRNAs (UNQ697, BX571672.5, CYP4F35P, ANKRD20A5P, and AL832737) were observed to be significantly down‐regulated. The lncRNAs RP11‐697M17.1, and UNQ697 were detected with the highest up‐regulation and down‐regulation, respectively. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed that the up‐regulated lncRNAs were significantly enriched in 20 signaling pathways such as phosphoinositide‐3‐kinase–protein kinase B (PI3K‐Akt) pathway, and the down‐regulated lncRNAs target genes were significantly enriched in 20 signaling pathways such as the metabolic pathway.ConclusionThe analysis of the lncRNA expression profiles in plasma of children with chronic gastritis revealed that the lncRNA RP11‐697M17.1, and lncRNA UNQ697 may act as plasma markers for predicting chronic gastritis in children.
Does Investor-State Dispute Settlement Discriminate Against Nationals?
Authors: Riffel Christian 
Published: February 2020

AbstractThis Article answers the question of whether investor-state dispute settlement (“ISDS”) discriminates against nationals by providing foreign investors with an extra avenue to challenge state measures. The complaint that ISDS is discriminatory as a matter of principle has surfaced before several European constitutional courts—including the German Federal Constitutional Court and the European Court of Justice—in connection with the ratification of the Comprehensive Economic and Trade Agreement between Canada and the European Union (“CETA”). This Article rejects this complaint. The Federal Constitutional Court was able to leave the question of discrimination open in the applications for a preliminary injunction to stop ratification. It will have to take a stand, however, in the principal proceedings. If the Court were to side with the applicants, it would sound the death knell not only for the CETA in its present form, but also for the multilateral investment court system promoted by the European Union and, in particular, Germany. The point made by the applicants in the CETA complaint is not only of importance in a European constitutional law context. Whether ISDS is per se discriminatory is a fundamental issue which requires answering before any reform steps in relation to ISDS are addressed.
The Schmitelsen Court: The Question of Legitimacy
Authors: Bassok Or 
Published: February 2020

AbstractIn recent years, a new creature has emerged on the institutional landscape: The Schmitelsen Court. This court is the end-product of a combination of the positions presented by Hans Kelsen and Carl Schmitt in their famous debate over the institutional identity of the guardian of the constitution during the Weimar years. The Schmitelsen guardian is a court thus fulfilling Kelsen’s vision of the constitutional court as the guardian of the constitution. Nevertheless, it possesses the mission, the means to achieve it, and the source of legitimacy that Schmitt envisioned for the president as the guardian of the constitution. In this Article, I focus on the Schmitelsen Court’s source of legitimacy that differs greatly from the traditional source of judicial legitimacy that Kelsen envisioned for the guardian. Whereas Kelsen viewed legal expertise as the guardian’s source of legitimacy, Schmitt viewed public support as filling this role. After analyzing these two positions, I explain why it is vital for the Schmitelsen Court to harness public support as its source of legitimacy. I proceed by examining how the Schmitelsen Court model manifests itself in three case studies. In the US, Alexander Hamilton—in The Federalist No. 78—raised the notion of the guardian of the constitution long before Schmitt and Kelsen. He designated the judiciary as the guardian and ascribed its source of legitimacy to expertise. After describing how in recent decades the US Supreme Court adopted the Schmitelsen understanding of judicial legitimacy, I turn to examine the Israeli Supreme Court and the European Court of Human Rights. The relevance of these latter two courts stems not only from their adoption of the Schmitelsen Court’s understanding of judicial legitimacy, but also from the strong influence of the Weimar lessons on their evolution into Schmitelsen guardians.
Gene expression in peripheral blood in treatment-free major depression
Authors: Cuellar-Barboza Alfredo B. , Sánchez-Ruiz Jorge A. , Rodriguez-Sanchez Iram P. , González Sarai , Calvo Geovana , Lugo José , Costilla-Esquivel Antonio , Martínez Laura E. , Ibarra-Ramirez Marisol 
Published: February 2020

AbstractBackground:Peripheral gene expression of several molecular pathways has been studied in major depressive disorder (MDD) with promising results. We sought to investigate some of these genes in a treatment-free Latino sample of Mexican descent.Material and Methods:The sample consisted of 50 MDD treatment-free cases and 50 sex and age-matched controls. Gene expression of candidate genes of neuroplasticity (BDNF, p11, and VGF), inflammation (IL1A, IL1B, IL4, IL6, IL7, IL8, IL10, MIF, and TNFA), the canonical Wnt signaling pathway (TCF7L2, APC, and GSK3B), and mTOR, was compared in cases and controls. RNA was obtained from blood samples. We used bivariate analyses to compare subjects versus control mean mRNA quantification of target genes and lineal regression modelling to test for effects of age and body mass index on gene expression.Results:Most subjects were female (66%) with a mean age of 26.7 (SD 7.9) years. Only GSK3B was differentially expressed between cases and controls at a statistically significant level (p = 0.048). TCF7L-2 showed the highest number of correlations with MDD-related traits, yet these were modest in size.Discussion:GSK3B encodes a moderator of the canonical Wnt signaling pathway. It has a role in neuroplasticity, neuroprotection, depression, and other psychiatric phenotypes. We found that adding population diversity has the potential to elicit distinct peripheral gene expression markers in MDD and MDD-related traits. However, our results should only be considered as hypothesis-generating research that merits further replication in larger cohorts of similar ancestry.
Dose–response relationship between dietary choline and lipid accumulation in pyloric enterocytes of Atlantic salmon (Salmo salar L.) in seawater
Authors: Hansen Anne K. G. , Kortner Trond M. , Denstadli Vegard , Måsøval Kjell , Björkhem Ingemar , Grav Hans J. , Krogdahl Åshild 
Published: February 2020

AbstractFoamy, whitish appearance of the pyloric caeca, reflecting elevated lipid content, histologically visible as hypervacuolation, is frequently observed in Atlantic salmon fed high-plant diets. Lipid malabsorption syndrome (LMS) is suggested as term for the phenomenon. Earlier studies have shown that insufficient supply of phospholipids may cause similar symptoms. The objective of the present study was to strengthen knowledge on the role of choline, the key component of phosphatidylcholine, in development of LMS as well as finding the dietary required choline level in Atlantic salmon. A regression design was chosen to be able to estimate the dietary requirement level of choline, if found essential for the prevention of LMS. Atlantic salmon (456 g) were fed diets supplemented with 0, 392, 785, 1177, 1569, 1962, 2354, 2746 and 3139 mg/kg choline chloride. Fish fed the lowest-choline diet had pyloric caeca with whitish foamy surface, elevated relative weight, and the enterocytes were hypervacuolated. These characteristics diminished with increasing choline level and levelled off at levels of 2850, 3593 and 2310 mg/kg, respectively. The concomitant alterations in expression of genes related to phosphatidylcholine synthesis, cholesterol biosynthesis, lipid transport and storage confirmed the importance of choline in lipid turnover in the intestine and ability to prevent LMS. Based on the observations of the present study, the lowest level of choline which prevents LMS and intestinal lipid hypervacuolation in post-smolt Atlantic salmon is 3·4 g/kg. However, the optimal level most likely depends on the feed intake and dietary lipid level.
Haematologic malignancies associated with clozapine v. all other antipsychotic agents: a pharmacovigilance study in VigiBase®
Authors: Chrétien Basile , Lelong-Boulouard Véronique , Chantepie Sylvain , Sassier Marion , Bertho Mickael , Brazo Perrine , Humbert Xavier , Alexandre Joachim , Fedrizzi Sophie , Dolladille Charles 
Published: February 2020

AbstractBackgroundClozapine is mainly used in patients with treatment-resistant schizophrenia and may lead to potentially severe haematologic adverse events, such as agranulocytosis. Whether clozapine might be associated with haematologic malignancies is unknown. We aimed to assess the association between haematologic malignancies and clozapine using Vigibase®, the WHO pharmacovigilance database.MethodsWe performed a disproportionality analysis to compute reporting odds-ratio adjusted for age, sex and concurrent reporting of antineoplastic/immunomodulating agents (aROR) for clozapine and structurally related drugs (loxapine, olanzapine and quetiapine) compared with other antipsychotic drugs. Cases were malignant lymphoma and leukaemia reports. Non-cases were all other reports including at least one antipsychotic report.ResultsOf the 140 226 clozapine-associated reports, 493 were malignant lymphoma cases, and 275 were leukaemia cases. Clozapine was significantly associated with malignant lymphoma (aROR 9.14, 95% CI 7.75–10.77) and leukaemia (aROR 3.54, 95% CI 2.97–4.22). Patients suffering from those haematologic malignancies were significantly younger in the clozapine treatment group than patients treated with other medicines (p < 0.001). The median time to onset (available for 212 cases) was 5.1 years (IQR 2.2–9.9) for malignant lymphoma and 2.5 years (IQR 0.6–7.4) for leukaemia. The aROR by quartile of dose of clozapine in patients with haematologic malignancies suggested a dose-dependent association.ConclusionsClozapine was significantly associated with a pharmacovigilance signal of haematologic malignancies. The risk-benefit balance of clozapine should be carefully assessed in patients with risk factors of haematologic malignancies. Clozapine should be used at the lowest effective posology.
Comparison of Kane’s and Lagrange’s Methods in Analysis of Constrained Dynamical Systems
Authors: Talaeizadeh Amin , Forootan Mahmoodreza , Zabihi Mehdi , Nejat Pishkenari Hossein 
Published: February 2020

SUMMARYDynamic modeling is a fundamental step in analyzing the movement of any mechanical system. Methods for dynamical modeling of constrained systems have been widely developed to improve the accuracy and minimize computational cost during simulations. The necessity to satisfy constraint equations as well as the equations of motion makes it more critical to use numerical techniques that are successful in decreasing the number of computational operations and numerical errors for complex dynamical systems. In this study, performance of a variant of Kane’s method compared to six different techniques based on the Lagrange’s equations is shown. To evaluate the performance of the mentioned methods, snake-like robot dynamics is considered and different aspects such as the number of the most time-consuming computational operations, constraint error, energy error, and CPU time assigned to each method are compared. The simulation results demonstrate the superiority of the variant of Kane’s method concerning the other ones.
SELF-OWNERSHIP AND AGENT-CENTERED OPTIONS
Authors: Lazar Seth 
Published: February 2020

Abstract:I argue that agent-centered options to favor and sacrifice one’s own interests are grounded in a particular aspect of self-ownership. Because you own your interests, you are entitled to a say over how they are used. That is, whether those interests count for or against some action is, at least in part, to be determined by your choice. This is not the only plausible argument for agent-centered options. But it has some virtues that other arguments lack.
OWNERSHIP AND THE MORAL SIGNIFICANCE OF THE SELF
Authors: Tadros Victor 
Published: February 2020

Abstract:The idea of self-ownership has played a prominent role in justifying normative conclusions in moral and political philosophy. I argue that whether or not we are self-owners, there is no such role for it to play. Self-ownership is better thought a conclusion of moral and political arguments rather than their source. I then begin to explore an alternative idea—that the self is morally significant—that provides what those who rely on self-ownership ought to be looking for.
Experiential Learning Revisited: Lessons from a Student-Led Public Opinion Polling Class
Authors: Rinfret Sara R. , Angle Justin , Scott Samuel , Ward Daisy , Yang Kaixuan , Copeland Emily , Power Rebecca , Ray Thomas , Hiett Thomas 
Published: February 2020

ABSTRACTFor decades, political and private polling operations have informed about the public’s perceptions regarding a range of topics. In particular, universities (e.g., Marist and Quinnipiac) provide noteworthy research to inform and predict the outcomes of US elections. Yet, what role do our classrooms play in advancing the public opinion polling skills of our students? This article uses experiential learning as a descriptive framework to illustrate how a yearlong, immersive, and student-led public opinion polling experience, the Big Sky Poll, advances students’ social-science and data-fluency skills. Our findings suggest important insights into the future of public opinion polling from the vantage point of a rural Western state, which can be replicated in other academic institutions.
Must antidepressants be avoided in patients with neuroendocrine tumors? Results of a systematic review
Authors: Isenberg-Grzeda Elie , MacGregor Meredith , Matsoukas Konstantina , Chow Ngai , Reidy-Lagunes Diane , Alici Yesne 
Published: February 2020

AbstractObjectiveSymptoms of depression and anxiety are common in neuroendocrine tumor (NET), yet controversy exists over whether serotonin-mediated antidepressants (SAs) are safe in this population. We sought to address this knowledge gap.MethodFollowing PRISMA guidelines, we conducted a systematic review to identify NET patients who were prescribed SA.ResultsWe identified 15 articles, reporting on 161 unique patients, 72 with carcinoid syndrome (CS) and 89 without. There was substantial agreement between reviewers at the full-text stage (κ = 0.69). Three of the articles, all with low risk of bias, accounted for most of the cases (149/161; 93%). Among the 72 NET patients with CS prior to antidepressant usage, CS was exacerbated in 6 cases (8%), only 3 (4%) of whom chose to discontinue the antidepressant. The remaining 89 patients had no prior CS symptoms, and none developed CS following antidepressant usage. Overall, no instances of carcinoid crisis or death were reported.ConclusionsWe found no evidence for serious adverse outcomes related to SA usage in NET patients. Previous authors have recommended avoiding antidepressants in NET, but our findings do not support those recommendations. Oncologists should nonetheless monitor for symptom exacerbation when prescribing SA to patients with NET.
Multicriteria decision-support system to assess the potential of exclosure-based conservation in Ethiopia
Authors: Kibret Kefyalew Sahle , Haileslassie Amare , Mekuria Bori Wolde , Schmitter Petra 
Published: February 2020

AbstractLand degradation is a global challenge that affects lives and livelihoods in many communities. Since 1950, about 65% of Africa's cropland, on which millions of people depend, has been affected by land degradation caused by mining, poor farming practices and illegal logging. One-quarter of the land area of Ethiopia is severely degraded. As part of interventions to restore ecosystem services, exclosures have been implemented in Ethiopia since the 1980s. But the lack of tools to support prioritization and more efficient targeting of areas for large-scale exclosure-based interventions remains a challenge. Within that perspective, the overarching objectives of the current study were: (i) to develop a Geographic Information System-based multicriteria decision-support tool that would help in the identification of suitable areas for exclosure initiatives; (ii) to provide spatially explicit information, aggregated by river basin and agroecology, on potential areas for exclosure interventions and (iii) to conduct ex-ante analysis of the potential of exclosure areas for improving ecosystem services in terms of increase in above-ground biomass (AGB) production and carbon storage. The results of this study demonstrated that as much as 10% of Ethiopia's land area is suitable for establishing exclosures. This amounts to 11 million hectares (ha) of land depending on the criteria used to define suitability for exclosure. Of this total, a significant proportion (0.5–0.6 million ha) is currently under agricultural land-use systems. In terms of propriety river basins, we found that the largest amount of suitable area for exclosures falls in the Abay (2.6 million ha) and Tekeze (2.2 million ha) river basins, which are hosts to water infrastructure such as hydropower dams and are threatened by siltation. Ex-ante analysis of ecosystem services indicated that about 418 million tons of carbon can be stored in the AGB through exclosure land use. Ethiopia has voluntarily committed to the Bonn Challenge to restore 15 million ha of degraded land by 2025. The decision-support tool developed by the current study and the information so generated go toward supporting the planning, implementation and monitoring of these kinds of local and regional initiatives.
Across‐Arc Diversity in Rhyolites From an Intra‐oceanic Arc: Evidence From IODP Site U1437, Izu‐Bonin Rear Arc, and Surrounding Area
Authors: Heywood Luan J. , DeBari Susan M. , Gill James B. , Straub Susanne M. , Schindlbeck‐Belo Julie C. , Escobar‐Burciaga Ricardo D. , Woodhead Jon 
Published: February 2020

AbstractFelsic magmas from the Izu‐Bonin rear arc have compositions that resemble average continental crust in some respects. In order to understand their origin, we studied 1.1–4.4 Ma tephras in a rear‐arc drill core from International Ocean Discovery Program Expedition 350, Site U1437. They provide a well‐dated record of changing magmatic compositions during the early stages of the most recent episode of Izu‐Bonin arc rifting. Based on our comprehensive recontextualization of published analyses of <7 Ma regional dredged rocks across the arc, basalts to rhyolites are shown to vary in coherent chronological and spatial trends and can be classified into three series: light rare earth element‐depleted volcanic front series; a rift‐related series with nearly flat rare earth element patterns; and light rare earth element‐enriched rear‐arc seamount chain‐type (RASC‐type) series, which are abundant in the studied Site U1437 tephra record. All three series erupted simultaneously between 4.4 and 1.1 Ma, including the RASC‐type rhyolites which erupted until 1.1 Ma in significant quantities. Remarkably, trace element and radiogenic isotope ratios are similar between rhyolites and basalts from the same region. This recontextualization of rhyolite affinity represents a significant departure from existing frameworks. Geochemical modeling shows that fractional crystallization can largely explain <4.4 Ma RASC‐type rhyolites with some additional open system processing evident in rhyolites with >73% SiO2. However, trace element and Hf isotope ratios preclude rear‐arc rhyolite derivation by partial melting of the Oligocene‐Eocene arc basement. Thus, we favor a model where fractional crystallization is more important than crustal melting in producing intra‐oceanic arc rhyolites in this region.