bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perfil de resistencia de microorganismos circulantes en una Institución Prestadora de Servicios de salud en el Departamento de Boyacá, 2018
Authors: Angarita Merchán Maritza , Di Filippo Iriarte Giselle , Mora Moreno Diana Patricia , Ferrebuz Cardozo Atilio Junior 
Published: December 2019

Introducción. La resistencia bacteriana ha tomado importancia en salud pública, requiriendo establecer las relaciones existentes entre las infecciones, el manejo terapéutico y la expresión de los mecanismos de resistencia en microorganismos aislados en muestras hospitalarias. Objetivo. Reportar el perfil de resistencia de los microorganismos identificados en una institución prestadora de servicios de salud de tercer y cuarto nivel de atención en el Departamento de Boyacá durante un periodo de 6 meses en el año 2018. Materiales y métodos. Se llevó a cabo un estudio observacional, descriptivo y de corte transversal; los microorganismos fueron aislados de muestras clínicas de una institución prestadora de salud del departamento de Boyacá durante un periodo de 6 meses en el año 2018. Se realizó identificación, concentración mínima inhibitoria y pruebas confirmatorias de susceptibilidad según la Clinical and Laboratory Standards Institute M100-S23. Resultados. En los aislados evaluados predominaron los bacilos Gram negativos con un 86,4 % de estas 50% presentaron el fenotipo de resistencia Betalactamasas de espectro extendido, siendo Escherichia coli el microorganismo más frecuente. Staphylococcus aureus fue el único microorganismo Gram positivo aislado con 100% de cepas resistente a meticilina. Conclusiones. El microorganismo aislado con mayor frecuencia fue Escherichia coli y el mecanismo de resistencia más prevalente fue la producción de Betalactamasas de espectro extendido aisladas de muestras de orina.
Prevalencia de casos sospechosos de leptospirosis en pacientes reportados con diagnóstico de dengue al SIVIGILA, en el departamento de Boyacá 2016
Authors: Cuervo Díaz Diana Alexanadra , Pedraza-Bernal Adriana , Pinzón-Olmos Tania Alejandra 
Published: December 2019

Introducción. La leptospirosis es una zoonosis causada por bacterias del género Leptospira. En el hombre la enfermedad puede ser asintomática o cursar con un cuadro febril, hasta convertirse en una falla multisistémica, el diagnóstico diferencial se realiza con varias enfermedades, sin embargo, se ha encontrado una amplia asociación de leptospirosis y dengue en diferentes regiones del mundo. En Colombia es considerada como un evento de notificación obligatoria e individual al SIVIGILA desde el año 2007. Objetivo. Determinar la prevalencia de casos sospechosos de leptospirosis en pacientes reportados al SIVIGILA con diagnóstico de dengue en el departamento de Boyacá, durante el año 2016. Metodología. Se realizó un estudio observacional descriptivo de corte transversal. Se tomaron 336 fichas de notificación de dengue reportadas al SIVIGILA en el año 2016, se clasificaron como casos sospechosos aquellos reportes que presentaran síntomas de proceso infeccioso inespecífico con antecedentes epidemiológicos según el Instituto Nacional de Salud, y se evaluaron variables de tipo sociodemográficas, epidemiológicas y ocupacionales, a través de medidas descriptivas de frecuencias para variables cualitativas y medidas de tendencia central y dispersión para variables cuantitativas. Resultados. El número de casos sospechosos de leptospirosis entre los reportados con dengue, de acuerdo con la definición de caso sospechoso, fue de 11,3% (38/336). La frecuencia de casos por sexo fue una proporción igual (50%), tanto en hombres como en mujeres, y el lugar de mayor procedencia de los casos fue Muzo (26,3%); por otra parte, el 39,5% de los pacientes realizaban labores del campo, y las manifestaciones clínicas más representativas fueron la fiebre y hepatomegalia. Conclusiones. Debido a que los síntomas de leptospirosis son similares a otras infecciones febriles incluido el dengue, es de gran importancia un diagnóstico correcto, tanto clínico como de laboratorio; lo anterior, con el fin de evitar casos graves y, por supuesto, salvar vidas, especialmente en situaciones de brotes.
Uso de cánula nasal de alto flujo en falla respiratoria en adultos
Authors: Valero Ortiz Adriana , Umbacía Salas Flor Angela , Palencia Mojica Clara Lizeth , Suárez Saavedra Magda Tixiana , Silva Rodriguez Laura Jimena 
Published: December 2019

Introducción. La oxigenoterapia brinda un gran número de beneficios para aquellos pacientes que presentan enfermedades cardiorrespiratorias, mejora procesos fundamentales como ventilación, oxigenación y perfusión clínica. El objetivo de esta revisión de tema es analizar la evidencia de la literatura relacionada con la utilidad y uso de la cánula nasal de alto flujo, en pacientes adultos bajo cuidado intensivo, con falla respiratoria. Materiales y métodos. Se realizó una revisión bibliográfica de 100 artículos publicados en las bases de datos Science Direct, Scopus, Ovid, Medline, Proquest y Cochrane, durante una ventana de tiempo comprendida entre 2011 y 2017. Se seleccionaron 50 artículos originales y se excluyeron 50 estudios correspondientes a revisiones de tema, de caso y a la utilización de la cánula nasal en servicios diferentes a la unidad de cuidado intensivo adulto. Resultados. La cánula nasal de alto flujo fue utilizada en mayor proporción para el manejo terapéutico en falla hipoxémica entre leve y moderada, en falla hipercápnica y en procesos de preintubación y postextubación, con lo cual se evidenció mejoría en los parámetros clínicos y gasométricos y en el confort del paciente; además, se convirtió en una alternativa terapéutica que tiene efectos positivos sobre procesos fisiológicos. Conclusiones. El uso de la cánula nasal de alto flujo ha demostrado beneficios en la evolución clínica de los pacientes, gracias a los efectos terapéuticos que genera en procesos como la oxigenación y ventilación, comparados con otros sistemas de oxigenación convencional; sin embargo, es necesario aumentar los estudios que validen los beneficios de este dispositivo, sobre todo en los pacientes con falla respiratoria tipo hipercápnica.
Conocimientos sobre VIH/SIDA en uniformados usuarios de una Clínica Regional de Tunja
Authors: Niño-Castillo Clara Milena , Rodríguez-Álvarez Kevin Julián , Diaz-Niño Sandra Lizeth 
Published: December 2019

Introducción. El Virus de la Inmunodeficiencia Humana (VIH) es un virus que ataca el sistema inmunológico del ser humano, haciendo que su cuerpo sea susceptible a enfermedades e infecciones. En la actualidad el VIH continúa siendo un gran problema para la salud pública a nivel mundial pues ha causado más de 35 millones de muertes; para la Organización Mundial de la Salud (OMS) existen poblaciones que requieren especial atención por presentar alto riesgo de infección, en particular el personal militar, expuesto en mayor medida a las infecciones de transmisión sexual (ITS), incluido el Virus de la Inmunodeficiencia Humana (VIH) debido a su entorno de trabajo, movilidad, edad, entre otros factores. Objetivo. Determinar el nivel de conocimientos sobre VIH/SIDA en los usuarios uniformados de la Clínica Regional La Inmaculada, Tunja 2018. Materiales y métodos. Investigación original de tipo observacional descriptivo en la que se aplicaron 153 cuestionarios divididos en 4 secciones: datos sociodemográficos, conocimientos sobre formas de infección, creencias erróneas y conocimientos sobre formas de prevención del VIH/SIDA. Resultados. El 59.5% de la población se encuentra en un nivel excelente sobre la sección de conocimientos sobre formas de infección, el 67.2 % tienen un nivel excelente para creencias erróneas y el 76.5% demostraron tener excelentes conocimientos sobre formas de prevención del VIH/SIDA. Conclusión. Los resultados mostraron que la mayoría de los usuarios uniformados se encuentran en un nivel excelente de conocimientos, no obstante, es de vital importancia reforzar los programas de salud sexual y reproductiva dirigidos a este tipo de población.
Dimensionality of an urban transport system based on ISO 37120 indicators for the case of selected European cities
Authors: Hajduk Sławomira , Litavniece Lienite 
Published: December 2019

Abstract
The study aims to assess transport systems in terms of ISO 37120 indicators in selected European cities. Using the principal components analysis, the research identified significantly correlated variables associated with urban transport. Three principal components explained almost 87% of input data variability. The first principal component was mainly related to transportation fatalities, the second component — to the length of bicycle paths, and the third component — to the length of the network used by light passenger public transport. A strong correlation was found between the length of high capacity public transport and transportation fatalities. Furthermore, the analysis proved that the Aalter transport system was an outlier. The paper concludes by identifying several recommendations on the improvement of urban transport management and the development of low-carbon mobility systems.
Redesain Meja Cetakan Mesin 3D Printer Berbasis Fused Deposition Modelling
Authors: Cahyati Sally , Mulianto Dhifan Putra 
Published: December 2019

Mesin 3D printer adalah mesin pembuat suatu model 3D. Metode mesin 3D printer yang digunakan pada Fakultas Teknologi Industri Universitas Trisakti adalah metode FDM (Fused Deposition Modelling). Diketahui adanya ketidak stabilan pada meja cetakan mesin 3D printer pada saat proses produksi dilakukan. Ketidak stabilan meja cetakan mesin 3D printer, menyebabkan tidak maksimalnya produk yang dihasilkan. Terdapat perbedaan antara hasil produk dengan bentuk produk yang telah di desain sebelumnya. Setelah diteliti lebih lanjut, ketidak rataan pada meja disebabkan pada pengaturan meja cetakan yang kurang sesuai. Hasil dari redesain dapat menstabilkan meja cetakan dan memudahkan untuk melakukan kalibrasi dan pengaturan pada meja cetakan mesin 3D printer. Hal ini terbukti ketelitian dimensi produk hasil cetakan yang meningkat dari penyimpangan terbesar 0,037 mm menjadi 0,069 mm, yang diukur dengan proyektor profil yang mempunyai kecermatan 1 mikrometer.
3D Printer Machine is a 3D shaped model making machine. The method of 3D printer machine used by the faculty OF Industrial Technology of Trisakti University is FDM (Fused Deposition Modelling) method. There is known unevenness on the build plate of 3D printer machines during the production process. The unevenness that appears on the objects makes the build plate used by the 3D printer engine unstable. This causes the product to be produced not maximal. There is a difference in shape between product results and previous product design. After further investigation, the unevenness of the table was caused by the improper arrangement of the printed table. The results of the redesign will stabilize the print table and make it easier to calibrate and adjust the print table of the 3D printer machine. This proven that precision of product dimension increase from 0,037 mm deviation to 0,004 mm, its measured with a profile projector has 1 micrometer resolution.
Constructing a time scale of biotic recovery across the Cretaceous–Paleogene boundary, Corral Bluffs, Denver Basin, Colorado, U.S.A.
Authors: Fuentes Anthony J. , Clyde William C. , Weissenburger Ken , Bercovici Antoine , Lyson Tyler R. , Miller Ian M. , Ramezani Jahandar , Isakson Vincent , Schmitz Mark D. , Johnson Kirk R. 
Published: December 2019

ABSTRACT
The Cretaceous–Paleogene (K–Pg) boundary interval represents one of the most significant mass extinctions and ensuing biotic recoveries in Earth history. Earliest Paleocene fossil mammal faunas corresponding to the Puercan North American Land Mammal Age (NALMA) are thought to be highly endemic and potentially diachronous, necessitating precise chronostratigraphic controls at key fossil localities to constrain recovery dynamics in continental biotas following the K–Pg mass extinction. The Laramide synorgenic sedimentary deposits within the Denver Basin in east-central Colorado preserve one of the most continuous and fossiliferous records of the K–Pg boundary interval in North America. Poor exposure in much of the Denver Basin, however, makes it difficult to correlate between outcrops. To constrain fossil localities in coeval strata across the basin, previous studies have relied upon chronostratigraphic methods such as magnetostratigraphy. Here, we present a new high-resolution magnetostratigraphy of 10 lithostratigraphic sections spanning the K–Pg boundary interval at Corral Bluffs located east of Colorado Springs in the southern part of the Denver Basin. Fossil localities from Corral Bluffs have yielded limited dinosaur remains, mammal fossils assigned to the Puercan NALMA, and numerous fossil leaf localities. Palynological analyses identifying the K–Pg boundary in three sections and two independent, but nearly identical, 206Pb/238U age estimates for the same volcanic ash, provide key temporal calibration points. Our paleomagnetic analyses have identified clear polarity reversal boundaries from chron C30n to chron C28r across the sections. It is now possible to place the fossil localities at Corral Bluffs within the broader basin-wide chronostratigraphic framework and evaluate them in the context of K–Pg boundary extinction and recovery.
A shallow rift basin segmented in space and time: The southern San Luis Basin, Rio Grande rift, northern New Mexico, U.S.A.
Authors: Drenth Benjamin J. , Grauch V.J.S. , Turner Kenzie J. , Rodriguez Brian D. , Thompson Ren A. , Bauer Paul W. 
Published: December 2019

ABSTRACTInterpretation of gravity, magnetotelluric, and aeromagnetic data in conjunction with geologic constraints reveals details of basin geometry, thickness, and spatiotemporal evolution of the southern San Luis Basin, one of the major basins of the northern Rio Grande rift. Spatial variations of low-density basin-fill thickness are estimated primarily using a 3D gravity inversion method that improves on previous modeling efforts by separating the effects of the low-density basin fill from the effects of pre-rift rocks. The basin is found to be significantly narrower—and more complex in the subsurface—than indicated or implied by previous modeling efforts. The basin is also estimated to be significantly shallower than previously estimated. Five distinct subbasins are recognized within the broader southern San Luis Basin. The oldest and shallowest subbasin is the Las Mesitas graben along the northwestern basin margin, formed during the Oligocene transition from Southern Rocky Mountain volcanic field magmatism to rifting. In this subbasin, sediments are estimated to reach a maximum thickness of ~400 m within a north–south elongated structural depression. Other subbasins that likely initially developed during the Miocene are the dominant tectonic features in the southern San Luis Basin. This includes the Tres Orejas subbasin, which formed in the southwestern portion of the basin by the Embudo fault zone and a hypothesized fault zone along its western margin. This subbasin reaches a maximum thickness of ~2 km, as indicated by magnetotelluric and gravity modeling. The Sunshine Valley, Questa, and Taos subbasins occupy the eastern part of the southern San Luis Basin. The southern Sangre de Cristo fault zone is the dominant tectonic feature that controlled their development after ~20 Ma. The east-down Gorge fault zone controlled the western margins of significant parts of these eastern subbasins, although much of the Taos subbasin may be superimposed on the Tres Orejas subbasin. Maximum low-density basin-fill thicknesses are estimated to be 1.2 km for the Sunshine Valley subbasin, 800 m for the Questa subbasin, and 1.8 km for the Taos subbasin. Subbasin-forming tectonic activity along the Gorge fault zone and within the Tres Orejas subbasin ceased by the end of the development of the largely Pliocene Taos Plateau volcanic field. After that, rift-related subsidence became more narrowly centered on the eastern margin of the basin, controlled mainly by the linked Embudo and southern Sangre de Cristo fault zones.
Behavior of indirect maximal oxygen uptake on users of the prosa Program at Universidad de Antioquia, Medellín, Colombia
Authors: Márquez Jorge Jaime , Díaz Gildardo , Tejada Cristiam Paul 
Published: December 2019

Objective: This research work sought to describe the behavior of maximal oxygen uptake (VO2max) in a population of adults who performed regular physical activity and classify the level of cardio-respiratory fitness. Methods: 819 results were analyzed with the estimated 2000-m VO2max test from 2001 to 2009 of 125 subjects who exercise regularly in the PROSA program at Universidad de Antioquia and were discriminated by decade and gender. Results: The results showed that VO2max reached its peak between 30 and 39 years of age in men (52.0 ± 2.5 ml * kg-1 * min-1) and women (42.9 ± 3.5 ml * kg-1 * min-1). There were significant differences between the VO2max of men and women and the decline in all age groups, except for those over 70 years of age. The VO2max of men in the study was maintained between the 70 and 90 percentiles, while that of women was between 70 and 80 percentiles. Conclusion: The decline in VO2max associated with age is different for men and women and it is different in almost all age groups
Prevalence of abuse and related factors in a Colombian medical school
Authors: Guevara Cuéllar César Augusto , Botero Restrepo Sonia , Borrero-Castro Ingrid Lorena , Sinisterra Julián 
Published: December 2019

Introduction: Different forms of abusive practices are very common in medical schools and have serious implications on vocational and professional formation. The aim of this study is to determine the prevalence of perception of abuse in a university in Colombia and to identify associated factors.Methods: A cross-sectional study was conducted from September to December 2008 in a private medical school. A proportional cycle-based stratified sampling technique and randomized sampling per semester was done. Socio demographic, academic, and abuse-related variables were obtained.Results: One hundred twenty-eight students participated in the study. The prevalence of perception of abuse was 40.6%. The most common type of abuse was psychological (98%) and unjustified critique (10.9%), ridiculing (10.7%), shouting (10%), and discredit (9.5%) were the most frequent manifestations. Professors in preclinical courses were reported as the most prevalent abusers (25.9%), followed by clinical professors (19.8%). The frequency of abusive manifestations was rare (15.8% and 11.5%) in preclinical and clinical years, respectively. The abusive manifestations were most frequent in pathology and pediatrics in the preclinical and clinical years, espectively. Nineteen percent of the victims of abuse reported such to somebody. The main consequences were desire to withdraw from the career (63.2%) and change of career (36.8%). Increased perception of abuse (OR: 4.74 95% IC: 1.9-11.4 p=0.001) was associated during the clinical years.Conclusions: Although abusive practices are more frequent during clinical years, they do not constitute a systematic behavior among medical students from a private university in Colombia in comparison with other tudies.
Amiodarone-Induced Hypothyroidism
Authors: Chepurnenko Svetlana A. , Shavkuta Galina V. , Nasytko Alina D. 
Published: December 2019

Aim: to present a clinical case of amiodarone-induced hypothyroidism in a patient with paroxysmal atrial fi brillation.Results. Before taking amiodarone, the patient suffered from subclinical hypothyroidism. The level of thyroid stimulating hormone (TSH) was 6.2 mIU/L, thyroxine (T4) — 9.2 pmol/L. Against the background of taking amiodarone in a maintenance dose of 200 mg per day 5 days a week with a break of 2 days, clinically severe hypothyroidism developed with a TSH level of more than 16 mIU/L. An electrocardiogram (ECG) recorded sinus bradycardia with a heart rate (HR) of 37 beats per minute. Paroxysms of atrial fi brillation have stopped. According to the daily ECG monitoring recorded throughout the sinus rhythm with maximum heart rate of 92 beats/min., minimum of 35 beats/min. The circadian rhythm profi le was correct. No pauses were detected for more than two seconds. Transient atrioventricular block was of 1 degree (during sleep). Ectopic activity was represented by supraventricular extrasystoles 112 per day: 107 single, 1 pair, 1 group. Ventricular extrasystoles: 55 per day: polymorphic, solitary. No diagnostically signifi cant elevation or depression of the ST segment was detected. After the abolition of amiodarone, thyroid function was recovered. Levothyroxine was not prescribed. However, paroxysms of atrial fi brillation began to occur again. For the prevention of paroxysms, sotalol 160 mg per day was prescribed.Conclusion. Thus, the development of clinically pronounced amiodarone-induced hypothyroidism has contributed to the existing thyroid dysfunction in the patient. The assessment of the thyroid gland function and its further monitoring in the process of taking the drug is prescribed. Amiodarone therapy is performed in case of ineffectiveness of other antiarrhythmic drugs and, as a rule, is not used for primary prescription.
Cardioprotective Effectiveness of a Combination of 2-Ethyl-6-Methyl-3-Hydroxypyridine Enantiomers and Rosuvastatin in a Model of Doxorubicin Cardiomyopathy
Authors: Kolesnichenko Pavel D. , Pokhvoshcheva Ekaterina G. , Chakina Ekaterina S. , Reznikov Konstantin M. , Popova Irina A. , Dolzhikova Irina N. 
Published: December 2019

Aim. To study the cardioprotective effect of levorotatory ethylmethylhydroxypyridine malate enantiomer in combination with rosuvastatin on the model of doxorubicin cardiomyopathy.Material and methods. The research was conducted using 80 Langendorff perfused Wistar rat hearts (OOO “Kardioprotekt”, Saint-Petersburg) after a 3-day simulation of doxorubicin cardiomyopathy. The selection criteria for the evaluation of cardioprotective effect in the administration of ethylmethylhydroxypyridine derivatives and their combination with rosuvastatin were the indicators of left ventricular contractility, Tension-Time Index (t TTI), the diameter of cardiomyocytes.Results. During the experiment, it was found that the introduction of doxorubicin has a cardiotoxic effect, manifested through a decrease in the left ventricle contractility by 30–45% and an increase in the t TTI index by 4 times (“diastolic defect”). The introduction of a racemic mixture of ethylmethylhydroxypyridine malate at a dose of 93 mg/kg prevents the reduction of the left ventricle contractility and prevents the development of a “diastolic defect”, restraining the increase in the t TTI index by 32%, while the ethylmethylhydroxypyridine enantiomer at a dose of 93 mg/kg is more effective and its positive effect increases in combination with rosuvastatin at a dose of 0.4 mg/kg.Conclusion. The use of oxypyridine derivatives at doses of 50 mg/kg and 93 mg/kg, as well as their combination with rosuvastatin prevented the development of a “diastolic defect”. The highest effi ciency was revealed for the use of a combination of levorotatory ethylmethylhydroxypyridine malate enantiomer at a dose of 93 mg/kg with rosuvastatin at a dose of 0.4 mg/kg.
Multi-Stage Redox Systems Based on Dicationic P-Containing Polycyclic Aromatic Hydrocarbons
Authors: Delouche Thomas , Vacher Antoine , Caytan Elsa , Roisnel Thierry , Le Guennic Boris , Jacquemin Denis , Hissler Muriel , Bouit Pierre-Antoine 
Published: December 2019

In this communication, we report the straightforwardsynthesis of unprecedented electron-acceptors based on dicationic P-containing PAHs (Polycyclic Aromatic Hydrocarbons) where two phosphoniums are connected through various PAHs backbones. The impact of pi-extension on both the optical and redox properties is investigated using a joint experimental/theoretical approach.Finally, (spectro)-electrochemical studies prove that thesecompounds possess three redox states and EPR studies confirms the in situ formation of an organic radical.