bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological Activity of Matricaria chamomilla Essential Oils of
Various Chemotypes
Authors: Höferl Martina , Wanner Jürgen , Tabanca Nurhayat , Ali Abbas , Gochev Velizar , Schmidt Erich , Kaul Vijay K. , Singh Virendra , Jirovetz Leopold 
Published: July 2020

AbstractThe essential oil of Matricaria chamomilla L., which is commonly used for
medicinal and cosmetic purposes, can be differentiated between several
chemotypes. In the current study, six essential chamomile oil samples of various
origins (four of commercial sources, one of cultivation, one of wild collection)
were examined regarding their composition and biological activities,
i. e., antibacterial, antifungal, mosquito repellent, and larvicidal
effects. GC-MS analyses revealed that the samples largely varied in composition
and could be attributed to various chemotypes. In contrast to the other two
samples, the four commercial samples were unusually high in
trans-β-farnesene. The overall antimicrobial effects
were only moderate, but it could be shown that a higher content in
α-bisabolol and a smaller in α-bisabolol
oxides A and B had a positive effect on overall activity. All samples had a
biting deterrent effect comparable to DEET. Higher concentrations of
(Z )- and (E )-spiroethers improved larvicidal
activity, whereas trans-β-farnesene had the opposite
effect. In conclusion, the importance of α-bisabolol for the
biological activity of chamomile essential oil could be demonstrated.
Severe Lactic Acidosis in a Critically Ill Child: Think About Thiamine! A Case Report
Authors: Didisheim Clémence , Ballhausen Diana , Choucair Marie-Louise , Longchamp David , Natterer Julia , Ferry Thomas , Perez Marie-Hélène , Amiet Vivianne 
Published: July 2020

AbstractIn this article, we presented a teenager, in maintenance chemotherapy for leukemia, who was admitted for digestive symptoms related to a parasitic infection and required nutritional support with parenteral nutrition. After 6 weeks, his condition worsened with refractory shock of presumed septic origin, necessitating extracorporeal membrane oxygenation. Despite hemodynamic stabilization, his lactic acidosis worsened until thiamine supplementation was started. Lactate normalized within 12 hours. Thiamine is an essential coenzyme in aerobic glycolysis, and deficiency leads to lactate accumulation through anaerobic glycolysis. Thiamine deficiency is uncommon in the pediatric population. However, it should be considered in patients at risk of nutritional deficiencies with lactic acidosis of unknown origin.
Progeroid Syndrome with Mitral Regurgitation: A Rare Case Report
Authors: Chakravarthi D. P. Kalyana , Kishore Yalampati Rama , Naveen Kumar M. 
Published: July 2020

AbstractProgeroid syndromes (PS) involve the disorder of early aging. Although survival of progeria syndrome patients is nearly 15 years as per literature, the adult onset progeroid starts manifesting in the third decade. Here, we are presenting a rare case of progeroid at the age of 45 years with mitral regurgitation (MR). The patient has alopecia, dry skin, frontal bossing, up staring eyes with bilateral corneal opacities, prominent nose with parrot beak appearance, thin upper lip, large, low-set ears, periorbital hyperpigmentation, micrognathia, retrognathia, and hyperpigmentation over lower abdomen/both feet and hands. Facial and skeletal manifestation are the major clinical features of the PS; along with the characteristics mentioned above, the patient also had severe eccentric MR. This patient has PS with mitral valve prolapse and severe MR. Most of the features of progeria exist in this patient, which manifested at a younger age. However, the progression of the external features and survival up to 45 years favors PS instead of progeria. Therefore, genetic analysis is mandatory to confirm. We are reporting this case due to the rarity of onset of symptoms within a younger age group; however, the progression of the disease was very slow, which may be a another variant of progeria/PS.
Mental Health Issues in Coronavirus Disease 2019 Pandemic: Evolving a Strategy
Authors: Patil Vaibhav , Gupta Ankit , Chadda Rakesh Kumar 
Published: July 2020

AbstractCoronavirus disease 2019 (COVID-19) pandemic has become a global health emergency in a short span of time. Novel kind of the disease, highly infectious nature, rapid progress with serious medical complications and risk of death, and absence of effective treatment and vaccine have all added to a community fear. Need for social distancing, social isolation, and quarantine in contacts further contributes to the fear and also creates a stigma. Declaration of lockdown in many parts of the world to prevent spread of illness has been associated with socioeconomic consequences with great loss to the world economy as well unemployment in a large section of the population. All these factors impose a high risk of mental health problems like anxiety, fear, worries, sleep disturbances, depression, etc. in the general population, and also worsening of the existing symptoms in persons with existing mental illness. The impact of the pandemic on mental health is likely to be long lasting, and a great challenge to the mental health professionals and the policy makers. This paper discusses various strategies to effectively manage the mental health issues in the light of limited availability of mental health resources and restricted access to health services due to lockdown in low-resource settings.
Structure-based development of a subtype-selective orexin 1 receptor antagonist
Authors: Hellmann Jan , Drabek Matthäus , Yin Jie , Gunera Jakub , Pröll Theresa , Kraus Frank , Langmead Christopher J. , Hübner Harald , Weikert Dorothee , Kolb Peter , Rosenbaum Daniel M. , Gmeiner Peter 
Published: July 2020

Significance
Orexin receptors belong to the superfamily of G-protein–coupled receptors (GPCRs) which represent the largest class of drug targets in humans. Despite the recent progress in structural biology, the development of subtype-selective orexin receptor and GPCR ligands in general remains challenging, due to the high sequence similarity among individual receptor subtypes. However, subtype-selective molecules are key to discerning the individual contributions of receptor subtypes to (patho-)physiology. Starting from the clinically used, non–subtype-selective orexin receptor antagonist suvorexant, we demonstrate how docking, crystallography, medicinal chemistry, and in vitro pharmacology can be combined to exploit single amino acid sequence differences for the discovery of subtype-selective probes. Such compounds will help to better understand orexin receptor pharmacology and develop promising drug candidates.
Wide lag time distributions break a trade-off between reproduction and survival in bacteria
Authors: Moreno-Gámez Stefany , Kiviet Daniel J. , Vulin Clément , Schlegel Susan , Schlegel Kim , van Doorn G. Sander , Ackermann Martin 
Published: July 2020

Significance
The biology of many microorganisms has been adapted to a feast-and-famine lifestyle. Thus, understanding population dynamics during transitions from starvation to resource abundance is important for fundamental and applied reasons. Here, we study starved populations of bacteria encountering new resources and ask how the behavior of single cells gives rise to emergent population-level traits. We find that growth and survival of populations are dominated by phenotypic minorities: small subpopulations with extreme lag times. As a consequence, starved populations of bacteria can break a fundamental life history trade-off between growth and survival by evolving phenotypic variation in lag time. By showing why bacteria can sustain subpopulations with long lag times our findings can explain the prevalence of antibiotic tolerance by lag.
Tumor cell lysate-loaded immunostimulatory spherical nucleic acids as therapeutics for triple-negative breast cancer
Authors: Callmann Cassandra E. , Cole Lisa E. , Kusmierz Caroline D. , Huang Ziyin , Horiuchi Dai , Mirkin Chad A. 
Published: July 2020

SignificanceIn mouse models of triple-negative breast cancer, we show that the oxidation of tumor cells prior to lysate generation, coupled with their compartmentalization in the core of liposomal spherical nucleic acids (SNAs) comprised of adjuvant DNA, yields a powerful immunotherapeutic that significantly inhibits tumor growth, dramatically extends survival, and promotes a tumoricidal immune cell population within the tumor microenvironment. Specifically, this work points toward the importance of properly packaging and presenting the adjuvant and antigens such that biodistribution, dendritic cell activation, and therapeutic efficacy can be controlled.
Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6
Authors: Yuan Zuanning , Schneider Sarah , Dodd Thomas , Riera Alberto , Bai Lin , Yan Chunli , Barbon Marta , Magdalou Indiana , Ivanov Ivaylo , Stillman Bruce , Li Huilin , Speck Christian 
Published: July 2020

Significance
The loading of the core Mcm2-7 helicase onto origin DNA is essential for the formation of replication forks and genomic stability. Here, we report two cryo-electron microscopy (cryo-EM) structures that capture helicase loader–helicase complexes just prior to DNA insertion. These pre-loading structures, combined with a computational simulation of the dynamic transition from the pre-loading state to the loaded state, provide crucial insights into the mechanism required for topologically linking the helicase to DNA. The helicase loading system is highly conserved from yeast to human, which means that the molecular principles described here for the yeast system are likely applicable to the human system.
A Dutch dose of dissent
Authors: Labrie Nanon , Akkermans Aranka , Hample Dale 
Published: July 2020

Abstract
The Dutch are often thought of as direct, verbally aggressive, and argumentative. Yet, evidence for this
stereotype is lacking. This study explores argumentative predispositions in the Netherlands. In a survey, Dutch students’
(N = 133) argumentativeness, verbal aggressiveness, argument frames, and conflict personalization were
measured. The effects of gender and education were assessed. To explore the role of Dutch culture on argumentativeness,
comparisons to U.S. students (benchmark) were made. Overall, Dutch students showed orientations, expectations, and understandings
of argumentation as being useful and enjoyable, and seemed to experience argumentation predominantly positive. Males were more
aggressive than females, and students in higher professional and university (preparatory) education were more constructive than
students in vocational education. In contrast to expectations, Dutch students did not appear more predisposed to argue than U.S.
students. Dutch students prioritized prosocial behaviors and professional reflection, thereby tempering aggression in arguing.
Thus, argumentativeness is certainly not merely (stereo)typically Dutch.
How does an RNA selfie work? EV‐associated RNA in innate immunity as self or danger
Authors: Xiao Yu , Driedonks Tom , Witwer Kenneth W. , Wang Qian , Yin Hang 
Published: July 2020

ABSTRACTInnate immunity is a first line of defence against danger. Exogenous pathogen‐ or microbe‐associated molecular patterns (PAMPs or MAMPs) trigger innate immune responses through well‐understood cellular pathways. In contrast, endogenous damage‐associated molecular patterns (DAMPs) convey “danger signals” via their (mis)localization or modification. Both MAMPs and DAMPs are often communicated on or within extracellular vesicles (EVs). Despite growing evidence for the importance of EVs and their cargo in modulating innate immune responses, in some cases, it is unclear how EV‐transported molecules are sensed as abnormal. In particular, EVs constitutively carry RNA, which is also abundant in the cytoplasm. How, then, would RNA convey a danger signal as a cargo of EVs? In this Perspective, we offer some thoughts on how EV‐associated RNAs might raise the alarm for innate immune responses – or silence them.
Dynamics of chiral cosmology
Authors: Paliathanasis Andronikos 
Published: July 2020

Abstract
We perform a detailed analysis for the dynamics of chiral cosmology in a spatially flat Friedmann–Lemaître–Robertson–Walker Universe with a mixed potential term. The stationary points are categorized in four families. Previous results in the literature are recovered while new phases in the cosmological evolution are found. From our analysis we find nine different cosmological solutions, the eight describe scaling solutions, where the one is that of a pressureless fluid, while only one de Sitter solution is recovered.
Searching for MHz gravitational waves from harmonic sources
Authors: Martinez Jeronimo G. C. , Kamai Brittany 
Published: July 2020

Abstract
A MHz gravitational wave search for harmonic sources was conducted using a 704 h dataset obtained from the Holometer, a pair of 40 m power recycled Michelson interferometers. Our search was designed to look for cosmic string loops and eccentric black hole binaries in an entirely unexplored frequency range from 1 to 25 MHz. The measured cross-spectral density between both interferometers was used to perform four different searches. First, we search to identify any fundamental frequencies bins that have excess power above 5σ. Second, we reduce the per-bin threshold on any individual frequency bin by employing that a fundamental frequency and its harmonics all collectively lie above a threshold. We vary the number of harmonics searched over from n = 4 up to n = 23. Third, we perform an agnostic approach to identify harmonic candidates that may have a single contaminated frequency bin or follow a power-law dependence. Lastly, we expand on the agnostic approach for individual candidates and search for a potential underlying population of harmonic sources. Each method was tested on the interferometer dataset, as well as a dark noise, photon shot-noise-limited, and simulated Gaussian-noise datasets. We conclude that these four different search methods did not find any candidate frequencies that would be consistent with harmonic sources. This work presents a new way of searching for gravitational wave candidates, which allowed us to survey a previously unexplored frequency range.
Measurement of the tilt of the Earth’s axis during a lunar
eclipse using a simple method
Authors: Kucukozer Huseyin , Yurumezoglu Kemal , Kucukozer H Asuman , Suat Isıldak R 
Published: July 2020

Abstract
In this study, the tilt of the Earth’s axis was measured during a lunar
eclipse using a telescope based on the angle between the lunar orbit and
ecliptic planes being considered as approximately zero. The presented method not
only offers a practical and reliable way of measuring the axial tilt of the
Earth during a lunar eclipse but also helps in providing a higher
argumentation-based conceptual understanding and awareness of astronomical
events and their results through the combination of observation with
measurement.
Real-time reconstruction of long-lived particles at LHCb using FPGAs
Authors: Cenci Riccardo , Di Luca Andrea , Lazzari Federico , Morello Michael J. , Punzi Giovanni 
Published: July 2020

Abstract
Finding tracks downstream of the magnet at the earliest LHCb trigger level is not part of the baseline plan of the upgrade trigger, on account of the significant CPU time required to execute the search. Many long-lived particles, such as KS
0 and strange baryons, decay after the vertex track detector, so that their reconstruction efficiency is limited. We present a study of the performance of a future innovative real-time tracking system based on FPGAs, developed within a R&D effort in the context of the LHCb Upgrade Ib (LHC Run 4), dedicated to the reconstruction of the particles downstream of the magnet in the forward tracking detector (Scintillating Fibre Tracker), that is capable of processing events at the full LHC collision rate of 30 MHz.
A preliminary study of phases, elemental mapping, and electrical properties on Na2FeSiO4 derived from rice husk silica
Authors: Riyanto A , Sembiring S , Amalia A R , Astika A , Marjunus R 
Published: July 2020

Abstract
This work reports a preliminary investigation about the phase, element mapping, and electrical properties of Na2FeSiO4 prepared from rice husk silica, (FeNO3)3.9H2O, NaOH, and C6H8O7.H2O using the sol-gel method. A sample sintered at 800 °C with a holding time of 10 hours at peak temperature. The phases identification shows that the main phase of Na2FeSiO4 had been formed in the sample accompanied by two impurity phases, i.e., Na2SiO3 and SiO2. Elemental mapping shows that Na, Fe, Si, and O elements are evenly distributed over the entire surface of the sample. The band gap energy value of the sample is relatively small, around 2.58 eV - 2.87 eV. Its electrical conductivity varies depending on frequency, i.e., 6.13×10−5 S/m at 1 Hz and decreases gradually up to 4.27×10−5 S/m at 1000 Hz.
Application of learning models conceptual understanding procedures by using experimental methods on understanding physics concepts of students
Authors: Nurlina N , Lestari R A , Riskawati R 
Published: July 2020

Abstract
This study was True Experimental Research aimed to know : (1) Understanding the concept of physics concept of education by using Conceptual Understanding Procedures Models Using The Experimental Methods and Konvensional Models, (2) To Improving the understanding of the concept of students physics in X MIA 1 and X MIA 2 and (3) The difference in understanding the concept of the student taught to use Conceptual Understanding Procedures Models Using The Experimental Methods and not to use Conceptual Understanding Procedures Models Using The Experimental Methods. The Population in this Research is an X class in Muhammadiyah High School of Limbung there are 60 people divided into two classes that X MIA 1 and X MIA 2 Class. The sample of this research was taken randomly with the random sampling technique as many as two-class are X MIA 1 and X MIA 2. The Instruments of Research used the instruments of understanding the concept of physics in the dual form is 35 number of multiple-choice that meet valid criteria. From the research that has been done can be concluded : (1) Understanding of the concept of a well-taught concept of education by using Conceptual Understanding Procedures (CUPs) Models Using The Experimental Methods are in the middle category, (2) Understanding of the concept of a well-taught concept of education by using Conventional Models are in a Low category, (3) There’s a difference in understanding the concept of the student taught to use Conceptual Understanding Procedures (CUPs) Models Using The Experimental Methods and not to use Conceptual Understanding Procedures Models Using The Experimental Methods.
Development of physics practicum module based on collaborative teamwork learning model
Authors: Mustari M , Marwoto P , Iswari R S , Ginanjar F A , Anjelinar Y 
Published: July 2020

Abstract
This study aims to determine the feasibility of physics practicum modules based on collaborative teamwork learning models. Type of this research is a Borg and Gall development research. The stages are potential and problem, data collection, product design, design validation, product revision, product trial. The research subjects involved consisted of experts (material, media and religious) and VII grade students of SMP / MTs. The expert gives an assessment of the level of validity of the material and the suitability of the design physics practicum modules, while students assess the level of physics practicum modules. The results obtained were the feasibility of a physics practicum module based on collaborative teamwork learning models based on expert judgment was considered very feasible, with the percentage of material expert validation 83.40%, media experts 87.41%, and religious experts 95%. Educators and students response ositively to the attractiveness of physics practicum modules based on collaborative teamwork learning models as learning media, with the percentage of educator responses 93.75%, small group test 90.19%, and field testing 91.18%. The development of physics practicum modules based on collaborative teamwork learning models was declared very feasible and received a positive response to be used as a learning media.
Digital oscillation rails: developing physics learning media to determine the acceleration value of earth’s gravity
Authors: Diani R , Satiarti R B , Lestari N , Haka N B , Reftyawati D , Padilah A , Komikesari H 
Published: July 2020

Abstract
This research aims to develop a feasible learning media for high school physics learning on mathematical swing material, especially in determining the value of Earth’s gravitational acceleration. The learning media developed is a visual aid in the form of digital oscillation rails. This is a research and development research using the ADDIE model (analysis, design, development, implementation, and evaluation). The results of validation, teacher responses, and trials to students indicate that the developed digital oscillation rails are in the highly feasible category. Digital oscillation rails made of two oscillations tracks. The average values of gravitational acceleration obtained based on three experiments are 9.05 m / s2 for a track with 25 cm radius and 9.97 m / s2 for a track with 15 cm radius.
Flipped classroom mode for geometry optics teaching and learning: teachers’ perceptions and expectations
Authors: Asmayanti D , Abdurrahman A , Viyanti V , Herlina K 
Published: July 2020

Abstract
Integrating active learning with traditional learning in the classroom can actually be done simply. However, teachers are still trying to find learning innovations so the learning process can be focused on each student. One of the learning models that can be used by teachers is flipped classroom. This study aims to analyze the perceptions and expectations of teachers towards the use of flipped classroom models for the learning process of physics. The research model used is a mixed-method with Sequential Explanatory Strategy. The study was conducted in high schools in the Lampung province with the subjects of the research were 60 physics teachers. Data collection used a four-point questionnaire instrument with Likert Scale and interviews. The results of the study showed that teachers had considerable expectations for the use of flipped classroom model. The flipped classroom learning model can help teachers to convey all the physics material easily so as students can understand the material, active, interest with physics, then communication and the relationship between teachers and students will increase. The flipped classroom model will work well if it is supported by appropriate media and teaching materials. The results of this study will be a reference for the next research.
Optimization of using Baturaja fly ash as a Portland Composite Cement (PCC) additive
Authors: Rumiyanti L , Wulandari S , Damayanti T , Sembiring S , Warsito W 
Published: July 2020

AbstractThere has been researched on the optimization of fly ash Baturaja as a cement additive PCC. The purpose of this research is to know the optimal percentage of fly ash, which can be added to the process of making PCC cement, which still produces excellent quality cement and fulfills SNI and knowing the effect of adding fly ash to physical testing and chemical testing. The test was done physically, Blaine test, setting time test and compressive strength test for three days, seven days, and 28 days. Meanwhile, chemical testing is the Loss of Ignition (LOI) test, Free Calcium Oxide (FCaO) test, and Insoluble Residue test (IR). Based on the result of research, the most optimal percentage is when adding 6% ash fly proportion. The higher the ratio of fly ash, will result in an unstable Blaine value. The higher the proportion of fly ash is added, the compressive strength will be smaller, and the setting time will be longer. Meanwhile, the higher the addition of fly ash, the value of loss of ignition, Free Calcium Oxide, and insoluble residue value will be higher.