bluuebunny/crossref_metadata_2025_split huggingface dataset:
The first case of microsporidiosis inParamecium
Authors: Yakovleva Yulia , Nassonova Elena , Lebedeva Natalia , Lanzoni Olivia , Petroni Giulio , Potekhin Alexey , Sabaneyeva Elena 
Published: April 2020

AbstractA new microsporidian species,Globosporidium parameciigen. nov., sp. nov., fromParamecium primaureliais described on the basis of morphology, fine structure, and SSU rRNA gene sequence. This is the first case of microsporidiosis inParameciumreported so far. All observed stages of the life cycle are monokaryotic. The parasites develop in the cytoplasm, at least some part of the population in endoplasmic reticulum and its derivates. Meronts divide by binary fission. Sporogonial plasmodium divides by rosette-like budding. Early sporoblasts demonstrate a well-developed exospore forming blister-like structures. Spores with distinctive spherical shape are dimorphic in size (3.7 ± 0.2 and 1.9 ± 0.2μm). Both types of spores are characterized by a thin endospore, a short isofilar polar tube making one incomplete coil, a bipartite polaroplast, and a large posterior vacuole. Experimental infection was successful for 5 of 10 tested strains of theParamecium aureliaspecies complex. All susceptible strains belong to closely relatedP. primaureliaandP. pentaureliaspecies. Phylogenetic analysis placed the new species in the Clade 4 of Microsporidia and revealed its close relationship toEuplotespora binucleata(a microsporidium from the ciliateEuplotes woodruffi), toHelmichia lacustrisandMrazekia macrocyclopis, microsporidia from aquatic invertebrates.
Human African trypanosomiasis: the current situation in endemic regions and the risks for non-endemic regions from imported cases
Authors: Gao Jiang-Mei , Qian Zheng-Yu , Hide Geoff , Lai De-Hua , Lun Zhao-Rong , Wu Zhong-Dao 
Published: April 2020

AbstractHuman African trypanosomiasis (HAT) is caused by Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense and caused devastating epidemics during the 20th century. Due to effective control programs implemented in the last two decades, the number of reported cases has fallen to a historically low level. Although fewer than 977 cases were reported in 2018 in endemic countries, HAT is still a public health problem in endemic regions until it is completely eliminated. In addition, almost 150 confirmed HAT cases were reported in non-endemic countries in the last three decades. The majority of non-endemic HAT cases were reported in Europe, USA and South Africa, due to historical alliances, economic links or geographic proximity to disease-endemic countries. Furthermore, with the implementation of the ‘Belt and Road’ project, sporadic imported HAT cases have been reported in China as a warning sign of tropical diseases prevention. In this paper, we explore and interpret the data on HAT incidence and find no positive correlation between the number of HAT cases from endemic and non-endemic countries. This data will provide useful information for better understanding the imported cases of HAT globally in the post-elimination phase.
Stories from the fourth age: autonomy and the lives of older care home residents
Authors: Pocock Lucy V. , MacKichan Fiona , Deibel Francesca , Mills Anna , Wye Lesley 
Published: April 2020

AbstractTransition to a care home often follows a hospital admission and can be distressing. Care home settings play an important role in the care of many people at the end of life. This longitudinal study employed a narrative approach, aiming to explore the perspectives of older care home residents on transitions to, and life and death within, care homes. Five participants, aged 85 years and over, were recruited from two privately owned care homes in the South-West of England. All participants had a diagnosis of an advanced progressive condition (excluding advanced dementia), or were thought to be frail. Longitudinal interviews (19 in total) were conducted over a ten-month period. A structural narrative analysis was performed and participants’ narratives are presented under three headings, with one participant's story chosen to illustrate each narrative type: ‘becoming a care home resident’, ‘living in a care home’ and ‘death and dying’. Findings revealed that care home residents experience a loss of autonomy and a lack of agency; they are often excluded from decision-making. Older care home residents have few choices with regard to care at the end of life. Further work is required to improve transition into care homes, including support and advocacy during decision-making, which often takes place in hospitals at a time of crisis.
Forms of trust and polypharmacy among older adults
Authors: Ross Alison , Gillett James 
Published: April 2020

AbstractThis article examines how older adults make decisions about their medications through interconnected axes of trust that operate across social networks. Trust is negotiated by older adults enrolled in a deprescribing programme which guides them through the process of reducing medications to mitigate risks associated with polypharmacy. Habermas’ work on the significance of communicative action in negotiating trust within social relationships informs our analysis, specifically in-depth semi-structured interviews with older adults about their medication use and the role of social networks in managing their health. Participants were age 70+ and experiencing polypharmacy. Our analysis discusses the social nature of medication practices and the importance of social networks for older adults’ decision-making. Their perspective reflects the critique of late-modern society put forward by Habermas. Negotiating trust in pharmaceutical decision-making requires navigating tensions across and between system networks (health-care professionals) and life-world networks (family and friends). This study contributes to our knowledge of how distinct forms of trust operate in different social spheres, setting the context for the way health-care decisions are made across social networks. Our analysis reinforces the need for older adults to engage meaningfully in health-care decision-making such that a convergence between system-world and life-world structures is encouraged. This would improve deprescribing programmes’ efficacy as older adults optimise their medication use and improve overall quality of life.
The epidemiology of affective disorders: national secular trends and local findings
Authors: Surtees P.G. , Sashidharan S.P. 
Published: April 2020

SummaryThis paper examines aspects of the epidemiology of affective disorders in Scotland. Results from 3 investigations are described, each one indicative of a particular research approach (the use of national, case-register and direct-interview based data). In Part I of the paper secular trends in Scottish national and local (Edinburgh city) first admission rates of affective disorders, based upon ICD-9, are examined. The results, based upon the national data, show that during the last two decades the male admission rate declined by 29.4% and the female rate by 37.3%. However, the female rate has remained 1.8 to 2.2-fold that of the male rate throughout this period. Further investigation of these changes was undertaken after dividing the affective disorder category into either the “affective psychoses” or the “depressive neuroses”. Results revealed that whilst there was only a slight change in the Scottish national rate of affective psychoses, marked decreases in rates were revealed for the depressive neuroses for both sexes (males by 39.4% and females by 39.3%). Age-specific secular trends also demonstrated the extent to which the older age groups of both sexes experienced the highest rates of affective psychoses.Results based upon first admissions for affective disorder to the Royal Edinburgh Hospital over the years 1976-1987 showed that the overall male rate had remained relatively unchanged, whilst that for females had declined by about 24%. Subsequent analysis showed that the rates for affective psychoses had declined over the 12 years to a level which for the females was close to the national rate but that the male rate for these conditions had remained (in 1985) at 70% above the Scottish national rate.Part II of this paper presents results from two further studies concerned with investigating rates of affective disorder amongst women. The first of these was a general population survey of a random sample, the second a hospital study. Both studies were designed to be complementary, in that each was based upon samples of women living in the same geographical area of Edinburgh city. Results revealed that the hospital prevalence estimate for affective disorders was only about 1% of the community estimate, but over 5% of the community inception rate. Analyses examining the demographic correlates of affective disorders revealed the extent to which age and marital status differentially determined the ease with which women entered hospital care. Results revealed that being single and of older age was associated with an increased chance of receiving treatment for women with affective disorders.
Writing Multilateral Trade Rules in the League of Nations
Authors: Dungy Madeleine Lynch 
Published: April 2020

AbstractThis article analyses the mechanics and the political stakes of multilateral trade negotiations in the League of Nations, in the context of the transition from empires to nation states. It examines one attempt to transfer bilateral treaty norms to a multilateral framework, the Draft Convention on the Treatment of Foreigners. This highly contested treaty addressed a policy question that was at the heart of both national sovereignty and international order – the legal treatment of foreign nationals. The attempt to regulate this question on a multilateral basis provoked intense debate about the authority of the League to mediate the relationship between international commerce and national governments.
Train Scheduling with Hybrid Answer Set Programming
Authors: ABELS DIRK , JORDI JULIAN , OSTROWSKI MAX , SCHAUB TORSTEN , TOLETTI AMBRA , WANKO PHILIPP 
Published: April 2020

AbstractWe present a solution to real-world train scheduling problems, involving routing, scheduling, and optimization, based on Answer Set Programming (ASP). To this end, we pursue a hybrid approach that extends ASP with difference constraints to account for a fine-grained timing. More precisely, we exemplarily show how the hybrid ASP system clingo[DL] can be used to tackle demanding planning and scheduling problems. In particular, we investigate how to boost performance by combining distinct ASP solving techniques, such as approximations and heuristics, with preprocessing and encoding techniques for tackling large-scale, real-world train-scheduling instances.
Genealogies of the “Paika Rebellion”: Heterogeneities and Linkages
Authors: Tanabe Akio 
Published: April 2020

AbstractThe “Paika Rebellion” of 1817 in Orissa, India has been depicted by colonial officers as a local disturbance caused by the dissatisfaction of one powerful individual deprived of traditional privileges who instigated thepāikas. The nationalist reconstruction has depicted the event as a popular freedom movement involving various castes and classes of Orissan society. This has culminated in a current move to declare the “Paika Rebellion” the First Indian War of Independence. I would like to suggest a third perspective, which focuses on the heterogeneities and linkages of the Rebellion. It is important to note that the “Paika Rebellion” was a meeting point of plural genealogies: “tribal” revolts to protect autonomy, “peasant” resistance to secure livelihood, restorative attempts by the traditional landed class, and ruling class efforts to defend and expand authority. Appreciating the plural genealogies of the Rebellion leads to more perceptive understandings of the heterogeneous characteristics of popular movements and their aftermaths in modern India. Lastly, in order to go beyond colonial and dominant-caste centred perspectives, I propose that we name it the “Orissa Uprising of 1817”.
Unbound in War? International Law and Britain's Participation in the Korean War
Authors: RICHMOND Sean 
Published: April 2020

AbstractThis interdisciplinary paper examines the influence and interpretation of international law in the use of force by an important but understudied country, Britain, during one of the most significant conflicts since 1945: the Korean War of 1950–53. Through innovative application of sociological theories in International Law [IL] and International Relations [IR], and rigorous qualitative analysis of declassified documents, I advance a two-pronged argument. First, contrary to what some dominant IR perspectives might predict, Britain's involvement in the war suggests that international law can play four underappreciated roles when states use force: (1) it helps constitute the identity of actors; (2) it helps regulate their conduct; (3) it permits and legitimates certain actions; and (4) it structures the process by which agents seek to develop new rules. However, contrary to what many IL approaches might predict, it is unclear whether these effects are ultimately attributable to an obligatory quality in law.
The evidence base for psychotropic drugs approved by the European Medicines Agency: a meta-assessment of all European Public Assessment Reports
Authors: Erhel Florian , Scanff Alexandre , Naudet Florian 
Published: April 2020

AbstractAimsTo systematically assess the level of evidence for psychotropic drugs approved by the European Medicines Agency (EMA).MethodsCross-sectional analysis of all European Public Assessment Reports (EPARs) and meta-analyses of the many studies reported in these EPARs. Eligible EPARs were identified from the EMA's website and individual study reports were requested from the Agency when necessary. All marketing authorisation applications (defined by the drug, the route of administration and given indications) for psychotropic medications for adults (including drugs used in psychiatry and addictology) were considered. EPARs solely based on bioequivalence studies were excluded. Our primary outcome measure was the presence of robust evidence of comparative effectiveness, defined as at least two ‘positive’ superiority studies against an active comparator. Various other features of the approvals were assessed, such as evidence of non-inferiorityv. active comparator and superiorityv. placebo. For studies with available data, effect sizes were computed and pooled using a random effect meta-analysis for each dose of each drug in each indication.ResultsTwenty-seven marketing authorisations were identified. For one, comparative effectiveness was explicitly considered as not needed in the EPAR. Of those remaining, 21/26 (81%) did not provide any evidence of superiority against an active comparator, 2/26 (8%) were based on at least two trials showing superiority against active comparator and three (11%) were based on one positive trial; 1/26 provided evidence for two positive non-inferiority analysesv. active comparator and seven (26%) provided evidence for one. In total, 20/27 (74%) evaluations reported evidence of superiorityv. placebo with two or more trials. Among the meta-analyses of initiation studies against active comparator (57 available comparisons), the median effect size was 0.051 (range −0.503; 0.318). Twenty approved evaluations (74%) reported evidence of superiorityv. placebo on the basis of two or more initiation trials and seven based on a single trial. Among meta-analyses of initiation studies against placebo (125 available comparisons), the median effect size was −0.283 (range −0.820; 0.091). Importantly, among the 89 study reports requested on the EMA website, only 19 were made available 1 year after our requests.ConclusionsThe evidence for psychiatric drug approved by the EMA was in general poor. Small to modest effectsv. placebo were considered sufficient in indications where an earlier drug exists. Data retrieval was incomplete after 1 year despite EMA's commitment to transparency. Improvements are needed.
Unterscheiden sich die Forschungsinteressen von Frauen und Männern in der Psychologie?
Authors: Bittermann André , Greiner Nina , Fischer Andreas 
Published: April 2020

Zusammenfassung. Auf die Mitte der 1990er Jahre angestoßene Debatte über den steigenden Frauenanteil unter den Psychologiestudierenden folgte eine Reihe von Studien, welche unter anderem geschlechtsspezifische Interessenschwerpunkte untersuchten. Bis heute zeigt sich zu solchen Präferenzen ein insgesamt gemischtes Bild und es liegt noch keine umfassende Untersuchung über einen größeren Zeitraum vor. Daher wurde untersucht, (1) ob sich die Forschungsinteressen von promovierenden Frauen und Männern in der Psychologie unterscheiden und (2) welche zeitlichen Trends hierbei ausgemacht werden können. Analysiert wurden 17 971 in der psychologischen Referenzdatenbank PSYNDEX nachgewiesene Dissertationen aus dem deutschen Sprachraum der Jahre 1968 bis 2017. Die individuellen Forschungsinteressen wurden anhand standardisierter Schlagwörter der Dissertationen mit Latent Dirichlet Allocation (LDA) identifiziert. Zeitliche Trends wurden mit Multilayer Perceptrons (MLP) untersucht. Es konnten 48 Interessenbereiche identifiziert werden, wobei sich nur in zwei Bereichen zeitlich konstant größere Unterschiede zwischen Frauen und Männern zeigten: „Mutter-Kind-Beziehung und Entwicklung im Kleinkindalter“ wurde mit einer höheren Wahrscheinlichkeit von Frauen, „Statistik und Methoden“ stärker von Männern adressiert. Weitere Unterschiede unterlagen zeitlichen Schwankungen. Die Befunde stützen insgesamt die Annahme, dass die Ähnlichkeiten zwischen Frauen und Männern überwiegen. Eine englische Übersetzung als Rohfassung dieses Artikels finden Sie als Elektronisches Supplement 1.
Resource Availability and Entrainment Are Driven by Offsets Between Nutriclines and Winter Mixed‐Layer Depth
Authors: Rigby S. J. , Williams R. G. , Achterberg E. P. , Tagliabue A. 
Published: April 2020

AbstractWhile phytoplankton play a key role in ocean biogeochemical cycles, the availability and supply pathways of resources that support their growth remain poorly constrained. Here, we show that the availability of various resources varies over several orders of magnitude throughout the Atlantic Ocean, causing regional contrasts in resource deficiency. Regional variations in the relative availability of nitrogen, phosphorous, silicon, iron, zinc, manganese, cobalt, and cadmium are important and result from the contrasts between winter mixing depths and differences in vertical profiles of the different resources. The winter‐time thickening of the mixed layer may replenish or deplete resources via entrainment, depending on the vertical nutrient profile. For nutrients like nitrate, phosphate, and cadmium, entrainment is a consistent source term. While for others, such as manganese and iron, entrainment can reduce ocean resource availability, particularly in subtropical regions. Any future change to the depth of winter‐time mixing will cause region‐specific changes in relative availability of different resources that may have important ecological consequences.
Basinwise Statistical Analysis of Factors Limiting Tropical Storm Formation From an Initial Tropical Circulation
Authors: Raavi Pavan Harika , Walsh K. J. E. 
Published: April 2020

AbstractTropical cyclones (TCs) form within a closed circulation region of large‐scale disturbances under certain dynamical and thermodynamical conditions. This study investigates differences in the large‐scale environmental conditions of a TC 48 hr before the declaration of tropical depression, comparing those that developed into tropical storms (TSs) with those depressions that did not develop. Here, we apply the Okubo‐Weiss Zeta Parameter detection and tracking scheme to ERA‐interim reanalysis from 1989–2018, across different ocean basins. The method detects storm‐system‐scale environmental conditions that favor TC formation. We construct spatial composites of thermodynamical and dynamical quantities for both developing and nondeveloping depressions, as well as storm‐relative streamlines. A statistical index (the Box Difference Index) is used to quantitatively estimate the dominant limiting factors of TS formation from the area‐averaged quantities of large‐scale variables. The relative contribution of large‐scale environmental variables impeding the development of an initial tropical depression to TS differs between ocean basins perhaps due to regional variations in the characteristics of large‐scale disturbances and the surrounding environmental conditions. A streamline analysis shows that the developing storms have a more pronounced cyclonic core and are protected from external influences by a stronger shear sheath layer surrounding the core extending from the lower to middle troposphere. This study, therefore, identifies the potential limiting variables and structural differences in an initial circulation that impede TS formation across different ocean basins.
Preorogenic Folds and Syn‐Orogenic Basement Tilts in an Inverted Hyperextended Margin: The Northern Pyrenees Case Study
Authors: Izquierdo‐Llavall Esther , Menant Armel , Aubourg Charles , Callot Jean‐Paul , Hoareau Guilhem , Camps Pierre , Péré Eve , Lahfid Abdeltif 
Published: April 2020

AbstractThe Chaînons Béarnais (CB, North Pyrenean Zone) resulted from the Cenozoic contractional reactivation of the salt tectonics‐bearing, hyperextended margin that initiated at the Europe‐Iberia transition during the Early Cretaceous. In this tectonic scenario, assessing the relative contribution of extension and contraction to the present‐day structure is crucial to reconstruct the hyperextended margin geometry and to quantify the subsequent shortening. This study undertakes this issue by defining the relationship between folding and two bedding‐independent references: peak temperature isotherms and paleomagnetic data. Isotherms were reconstructed from 76 new measurements of Raman spectroscopy on carbonaceous materials (RSCM) and indicate temperatures at the time of peak metamorphism in the CB (110–85 Ma, end of extension). They are shallowly to moderately northwards dipping and cut across most of the folds deforming the Mesozoic units. Paleomagnetic data from 29 sites evidence a widespread remagnetization carried by pyrrhotite that was probably blocked during the early Paleogene (before the onset of continental collision) and postdated folding in the CB. Abnormal inclinations in this remagnetization suggest syn‐collision tilts up to 60° to the north in the back limb of the Axial Zone. Based on the presented data set, we propose that the folding of the cover above the evaporitic décollement was almost fully completed by the end of the Cretaceous extension, with ~85–100% of the dip of fold limbs being acquired before the remagnetization time. Cenozoic contraction reactivated the extensional faults in the shallow basement as top‐to‐the‐S thrusts, leading to the passive transport and northwards tilting of the folded cover.