bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aktivitas sitotoksik dan antiangiogenesis umbi mentimun papasan (Coccinia grandis L.Voight) terhadap sel kanker hela yang diinduksi protein bFGF
Authors: Djamal Julia Megawati , P Jason Merari , Rukmana Rizal Maarif 
Published: July 2020

Background: Cancer is a leading cause of death in Indonesia and in the world. Cervical cancer is one of the most common cancers in women. One of the plants that has the potential to be developed as an alternative treatment for cancer is the papasan cucumber tuber (Coccinia grandis (L) Voight). This study aims to determine the activity of cytotoxic effects on Hela cancer cells and antiangiogenesis activity against Chorioallantoic membrane.
Method: In this study, papasan cucumber tubers were extracted with 96% ethanol solvent. The ethanol extract was then continued with fractionation using the liquid-liquid partition method, followed by thin-layer chromatography used to determine of compounds contained in the papasan cucumber tubers. Cytotoxic activity tests were carried out using the MTT assay method and antiangiogenesis tests were carried out using CAM methods of chicken embryos induced with bFGF protein.
Results: The results showed that the extract, n-hexane fraction, ethyl acetate fraction and water fraction had IC50 values 986,604 µg/ml, 208,776 µg/ml, 187,824 µg/ml and 553,393 µg/ml. The IC50 value of the n-hexane fraction was then continued with antiangiogenesis testing. The KLT analysis showed that the n-hexane fraction contained alkaloids, flavonoids, tannins, saponins, and terpenes. Antiangiogenesis test result show that the inhibitory at concentration of 104 µg / ml was 17,56%, at a concentration of 208 µg / ml 43,23% and at a concentration of 418 µg / ml 56,78%.
Conclusion: n-hexane fraction and ethyl acetate fraction have moderate cytotoxic activity against Hela cancer cells and n-hexane fraction has antiangiogenesis activity.
Key words: Coccnia grandis L. Voight, Cytotoxic, Antiangiogenesis, Hela, Chorioallantoic Membrane
Potensi Pseudomonas fluorescens dalam menghasilkan asam salisilat dengan menggunakan limbah udang sebagai substrat
Authors: Puspadewi Ririn , Adirestuti Putranti , Dewi Mira Andam , Tyas Aditya Ayuning 
Published: July 2020

Latar Belakang: Pemanfaatan limbah udang saat ini kurang mendapatkan perhatian dikarenakan kurangnya pengetahuan masyarakat akan manfaat kandungan dalam limbah udang. Limbah udang mengandung protein sebagai sumber nitrogen dan mineral sehingga dapat dimanfaatkan sebagai substrat untuk pertumbuhan mikroba Pseudomonas fluorescens dalam mensintesis asam salisilat. Tujuan penelitian adalah memanfaatkan limbah udang sebagai substrat untuk pertumbuhan Pseudomonas florescens dalam menghasilkan asam salisilat.
Metode: Ferrmentasi dilakukan pada suhu 30℃, pH 7 dengan pengocokan terus-menerus pada 150 rpm. Substrat dibuat dalam dua formula yaitu formula 1 (limbah udang), formula 2 (limbah udang dan 0,02% MgSO4). Asam salisilat sebagai produk fermentasi dianalisis secara kimia kualitatif dan uji aktivitas anti mikroba terhadap Staphylococcus aureus dan Propionibacterium acnes.
Hasil: Hasil penelitian menunjukkan bahwa uji kimia kualitatif dengan uji esterifikasi terdapat bau ester khas seperti minyak gandapura, uji dengan FeCl3 menunjukkan warna ungu, sedangkan uji dengan HCl menunjukkan hasil negatif. Uji aktivitas antimikroba terhadap Staphylococcus aureus menghasilkan zona bening sebesar 18,65 mm dan terhadap Propionibacterium acnes sebesar 19,65 mm dari formula 1 setelah fermentasi 28 jam.
Kesimpulan: Limbah udang dapat digunakan untuk susbtrat Pemanfaatan limbah udang saat ini kurang mendapatkan perhatian dikarenakan kurangnya pengetahuan masyarakat akan manfaat kandungan dalam limbah udang. pada pertumbuhan Pseudomonas flourescens dalam menghasilkan asam sitrat
The effect of compensation, work environment and work satisfaction toward employees performance at Regional Hospital of Prambanan
Authors: Nugroho Muhammad Aditya 
Published: July 2020

Efforts to improve the quality of a hospital should consider how job satisfaction of medical personnel, which will later have an impact on medical personnel performance. There are various ways that will be taken to improve performance, for example by providing appropriate compensation and improving quality of work environment conditions. Then job satisfaction is expected to increase and have a good impact on medical personnel performance at a hospital. The purpose of this study was to determine the effect of compensation, work environment and job satisfaction with employee performance at Prambanan Regional Hospital. This study used four variables namely compensation, work environment, job satisfaction and performance. The population in this study was employees who worked at Prambanan Regional Hospital, amounting to 300 people. The sampling technique used simple random sampling with a research sample of 150 people. Data analysis techniques used Structural Equation Modeling analysis. The result shows that there is a positive an significant effect between the compensation on the employee job satisfaction; there is a positive and significant effect between the work environment on the employee job satisfaction; there is a positive and significant effect between the compensation on the employee performance; there is a positive and significant effect between the work environment on the employee performance; there is no effect of the job satisfaction on the employee performance; satisfaction does not mediate the effect of compensation on the employee job satisfaction at Prambanan Regional Hospital.
Isolasi senyawa antibakteri dari batang sembung rambat (Mikania cordata (Burm.fil.))
Authors: Perawati Santi , Anggresani Lia , Swinche Ulfa Deni , Hartesi Barmi 
Published: July 2020

Latar Belakang : Tumbuhan sembung rambat merupakan gulma yang memiliki potensi antibakteri yang sangat besar. Tujuan penelitian ini untuk mendapatkan isolat metabolit sekunder dari batang sembung rambat yang mempunyai aktivitas antibakteri.
Metode : Isolasi senyawa antibakteri dari batang sembung rambat dilakukan dengan metode separation guided by activity. Dimulai dengan pengumpulan sampel, sortasi, ekstraksi, fraksinasi, isolasi,, uji aktivitas antibakteri, karakterisasi senyawa antibakteri dengan spektro UV-Vis dan FTIR. Ekstraksi dilakukan dengan menggunakan etanol 70%.
Hasil : Penapisan fitokimia ekstrak etanol batang sembung rambat mengandung metabolit sekundr alkaloid, flavonoid, polifenol, saponin, steroid, tannin dan kuinon. Uji aktivitas antibakteri terhadap ekstrak, fraksi etil asetat (Mc-II), subfraksi (Mc-II-A) dan isolat (Mc-II-A3) menunjukkan efektivitas terbesar terhadap bakteri S.aureus dan E.coli. pemisahan senyawa menggunakan metode ekstrak cair-cair (ECC), kromatografi cair vakum (KCV), kromatografi lapis tipis preparatif. Pemurnian isolat dilakukan dengan KLT dua arah
Kesimpulan : Identifikasi isolat aktif antibakteri (Mc-II-A3) dilakukan dengan menggunakan spektrofotometer UV-Vis dan FTIR. Spektrum UV menunjukkan panjang gelombang 222 nm dan analisis FTIR menunjukkan adanya C=C aromatis dan C=O. Sehingga dapat disimpulkan bahwa isolat aktif antibakteri dari batang sembung rambat diduga senyawa mikanolide.

Kata kunci: Antibakteri, Isolasi, Mikania cordata (Burm.fil.), Sembung rambat
Faktor resiko kaki diabetik pada diabetes mellitus tipe 2
Authors: Astuti Ani , Merdekawati Diah , Aminah Siti 
Published: July 2020

Abstrak

Latar Belakang : Kaki diabetik merupakan salah satu komplikasi Diabetes Mellitus yang dapat menyebabkan gangren pada kaki. Terjadinya kaki diabetik ini dapat dipengaruhi lama diabetes mellitus, perawatan kaki dan kontrol glikemik. Penelitian ini bertujuan untuk mengetahui hubungan lama diabetes mellitus, perawatan kaki dan kontrol glikemik dengan kejadian kaki diabetik di Puskesmas Putri Ayu Kota Jambi Tahun 2019.
Metode :Penelitian ini merupakan penelitian kuantitatif dengan desain cross sectional. Populasi dalam penelitian ini adalah seluruh penderita Diabetes Mellitus yang menjalani rawat jalan di Puskesmas Putri Ayu Kota Jambi yang berjumlah 1.036 orang dan pengambilan sampel dilakukan dengan menggunakan teknik purposive sampling dengan sampel berjumlah 60 responden. Data dianalisa secara Univariat dan Bivariat menggunakanuji Chi-square, instrumen penelitian ini menggunakan lembar kuesioner dan lembar pemeriksaan.
Hasil :Hasil analisis menunjukkan bahwa sebagian besar responden mengalami kaki diabetik (61,7%), menderita DM < 10 tahun (65%), melakukan perawatan kaki kurang baik (78,3%) dan kontrol glikemik yang tidak terkontrol (51,7%). Hasil analisis bivariat menunjukkan bahwa terdapat hubungan yang bermakna antara lama diabetes mellitus (p-value 0,011), perawatan kaki (p-value 0,023) dan kontrol glikemik (p-value 0,020) dengan kaki diabetik.
Kesimpulan :Dari hasil penelitian teridentifikasi bahwa lama diabetes mellitus, perawatan kaki yang kurang baik serta kontrol glikemik yang tidak terkontrol dapat beresiko terjadinya kaki diabetik.Diharapkan pihak puskesmas dapat membuat program pencegahan kaki diabetik dengan membuka poli kaki.
PENENTUAN SIFAT MAGNETIK PASIR DAN DEBU SEPANJANG JALAN KARTAMA KOTA PEKANBARU MENGGUNAKAN MAGNETIC PROBE PASCO PS-2162
Authors: Nainggolan Maria Sonya Nauli , Erwin Erwin , Yanuar Yanuar , Malik Usman 
Published: July 2020

Topsoil is the recipient of various kinds pollutants, especially heavy metals. Heavy metals have been detected in sand and dust along the highway. Measuring the magnetic properties of road sediment along Kartama road in Pekanbaru City has been done. The magnetic properties measured are magnetic degree, magnetic and mass susceptibility using magnetic induction measurement. The Samples were taken at sixteen locations with the amount of 1 or 2 kg for each point location, the samples were named as samples 16, 7a7e, 8a8e. The magnetic particles of the samples were separated from sand and dust using Iron Sand Separator and later using Neodymium Iron Boron (NdFeB) magnet. The total magnetic induction of the samples and concentrates were measured using Pasco Magnetic Probe PS-2162. In order to measure the magnetic induction of the samples, a solenoid of 3 cm in diameter, length of 10 cm and 2000 of windings was made. The empty solenoid magnetic induction was measured as a function of applied current ranging from 210 A and as a function of horizontal distance of 15 mm from the the solenoid ends. Total magnetic induction (samples and concentrates) was measured for the applied currents of 6 A. The results showed that the highest magnetic degree obtained from the sample number 7e that is 2.54% and the lowest level obtained from the sample number 3 that is 0.17%. The highest magnetic susceptibility value obtained from the sample number 7b was is 9158.12 , and the lowest magnetic susceptibility value obtained from the sample number 2 with the value of 3125.52 . Based on the mass susceptibility values of the concentrate obtained that the sand and dust along the road Kartama Pekanbaru which are in the interval 4.6 to 8.0, they implies that the mass susceptibility of the samples is in the range of Ilmenite phase FeTiO3or antiferromagnetic.
EFEK PENAMBAHAN ATOM TEMBAGA (Cu) DAN PERAK (Ag) PADA MATERIAL AKTIF NANOMATERIAL ZnO SEL SURYA FOTOELEKTROKIMIA
Authors: Windayani Windayani , Iwantono Iwantono , Awitdrus Awitdrus , Zulkarnain Zulkarnain 
Published: July 2020

ZnO material coated with Cu + Ag was successfully grown using seed mediated hydrothermal method at a temperature of 90° C for 8 hours with a variation of concentration of Ag, 10 mM, and 20 mM. The growth of ZnO nanomaterials was carried out on the FTO substrate (Flourine Tin Oxide). The Samples were characterized using, Field Emission Scanning Microscope (FESEM), and X-ray Diffraction (XRD). The FESEM photos show ZnOnanorod coated with Cu + Ag have grown on FTO having a nanoflower shape that consructed from ZnOnanorods with their orientation . The XRD pattern shows five peaks at 2θ: 31.69 °; 34.36 °; 36,18 °; 47.52 °; and 56.4 °. Based on the results of the analysis of the OriginPro 8 program each peak in a row according to the crystal orientation (100), (002), (101), (012), and (110). The stongest line was found in the crystal plane (101). DSSC was fabricated using ZnO nanomaterial coated with Cu + Ag as active material, N719 dye, liquid electrolyte, and plastisol as catalyst on the counter electrode. The results of I-V measurements at halogen lamp with ilumination its intensity of 100 mW/cm2 of the cells has producedthe highest efficiency value based on Cu coated ZnO was based DSSC 0,98% with a Cu concentration of20mM.These results show that the addition of Cu layer can increase the efficiency of DSSC based on ZnO by 123% compared to ZnO without Cu based DSSC. Addition of Ag to active material of Cu coated ZnO nanomaterial did not have a positive effect on the efficiency of DSSC cells.
PENENTUAN DENSITAS SPESIES PLASMA HIDROGEN PADA KESETIMBANGAN TERMODINAMIK TEKANAN ATMOSFIR MENGGUNAKAN MATLAB
Authors: Fardinata Reeky , Saktioto Saktioto 
Published: July 2020

Thermal equilibrium hydrogen plasma at atmospheric pressure were simulated using the software matrix laboratory (MATLAB). Runge Kutta method numerical method as a settlement of differensial model equations of chemical kibetik with the arrhenius equation approach and continuity equations so that the equilibrium density values for each species were obtained. Equilibrium hydrogen plasma at atmospheric pressure and density rate review every reaction involved. Parameter of ionizing and disasosiasi as a reference equilibrium plasma. Equilibrium plasma is found in time interval 10-6 – 10-3 s thermal hydrogen plasmas with temperatures of 1 eV. The density of hydrogen plasma thermal equilibrium overall are in the interval of 1014 m-3 - 1020 m-3 . The reaction rate of each species varies based on the type of collision and rate of change of species.
EFEK GELOMBANG TSUNAMI ACEH 2004 PADA GANGGUAN IONOSFER BERGERAK SKALA MENENGAH DARI PENGAMATAN JARINGAN GPS SUMATRA
Authors: Husin Asnawi , Muslim Buldan 
Published: July 2020

Medium Scale Travelling Ionospheric Disturbance (MSTID), thought to be manifestation of atmospheric gravity wave (AGW) in the ionospheric altitude that propagates horizontally and effects on in the electron density structure of ionosphere. These atmospheric gravity waves sourced from lower atmospheric activities such as typhoons, volcanic eruptions and tsunamis. Wave energy by its coupling induction process can travel to the ionosphere region. It has been understood that the TID's wave structure have an impact on the propagation of radio waves in the ionosphere so that it will affect the performance of navigation satellite-based positioning measurements. Based on Aceh tsunami in December 2004, this study aimed to investigation of the induction of atmospheric gravity waves in the ionosphere using total electron content (TEC) data from the Sumatra GPS network (Sumatra GPS Array, SUGAR). The detection technique of TEC changes due to AGW induction with a filter to separate medium scale disturbance at the ionospheric pierce point at an altitude of 350 km (IPP, Ionospheric Pierce Point). The results show the horizontal wavelength of a medium-scale TID around 180 ± 12 Km with a velocities of around 376 ± 9 ms-1. Based on two-dimensional map, the TID moves to the southeast.
PENENTUAN SIFAT MAGNETIK DAN MORFOLOGI PARTIKEL MAGNETIK PASIR BESI PANTAI ARTA PARIAMAN SUMATERA BARAT
Authors: Wulandhari Ayu , Erwin Erwin 
Published: July 2020

Telah dilakukan penelitian tentang sifat magnetik dan ukuran partikel dari pasir besi pantai Arta Pariaman Sumatera Barat menggunakan metode Ball Milling. Sampel pasir besi dipisahkan menggunakan Iron Sand Separator (ISS) sebelum dilakukannya proses penghancuran menggunakan Ball Milling dengan variasi waktu 30 jam, 60 jam, dan 90 jam, kemudian dilakukan Ball Milling lanjutan selama 30 jam pada sampel hasil Ball Milling 90 jam dengan ukuran bola yang diperkecil sebesar 0,6 cm. Untuk pemisahan antara partikel magnetik dan non-magnetik pada hasil Ball Milling menggunakan magnet batang Niodinium Iron Boron (NdFeB). Sifat magnetik seperti suseptibilitas magnetik dan suseptibilitas massa dapat diketahui dengan menggunakan sensor Pasco Magnetic Probe PS-2162 dengan kumparan solenoid 2000 lilitan, panjang 10 cm, dan diameter 3 cm, sedangkan komposisi dari pasir besi menggunakan X-Ray Fluorescence (XRF). Ukuran dan bentuk partikel magnetik ditentukan dengan Scanning Electtron Microscope (SEM). Dari penelitian ini hasil ukuran partikel yang didapat sebesar 935 nm untuk waktu Ball Milling 90 jam dan ukuran dalam rentang sebesar 519 nm untuk waktu Ball Milling 120 jam/90 jam + 30 jam, Bentuk partikel pasir besi hampir bulat untuk masing-masing waktu Ball Milling. Kandungan pasir besi sebelum dan sesudah di Ball Milling selama 120 jam yaitu 6,118% dan 67,746%. Suseptibilitas massa meningkat dari 27955,7 X 10-8 m3/kg menjadi 31478,5 X 10-8 m3/kg . Nilai ini berada dalam interval mineral Ilminite (46-80000) X 10-8 m3/kg .
ANALISIS EFEK GERHANA MATAHARI TOTAL 9 MARET 2016 TERHADAP KANDUNGAN TOTAL ELEKTRON IONOSFER
Authors: Ariani Afrita , Malik Usman , Husin Asnawi 
Published: July 2020

Total elektron contant in ionosphere is affected by several fastors, local time, solar aktivities, geomagnetic disturbance, geographical latitude and longitude. This researh aims to observase level variation of total electron contant during solar eclipse over Indonesia on 9 March 2016. We analyzed GPS data from two GPS stations in different locations with different sun observation geographical latitude and longitude, the locations were Sulawesi station (CAMP) and Maluku station (CAMB). The method used in this research, was data interpretation method computationally, the whole data analyzed using matlab software R2008a. The values of daily TEC range from 20 TECU till 30 TECU. Although the value of TEC when solar total eclipse range from 10n TECU untill 20 TECU. The percentage of decreasing value of TEC when total solar eclipse than the daily value of TEC. Decreasing of TEC value between 20%-40%.
The Efektivitas Sari Kurma Terhadap Peningkatan Kadar Hemoglobin Pada Ibu Nifas di Wilayah UPT Kereng Bangkirai Kota Palangka Raya
Authors: Tandja Yessica Harnetacia 
Published: July 2020

ABSTRAK
Latar Belakang: Anemia pada wanita masa nifas (pasca persalinan) juga umum terjadi, sekitar 10% dan 22% terjadi pada wanita post partum. Anemia terjadi jika kadar hemoglobin dalam darah rendah. Untuk mengurangi angka anemia post partum dapat dilakukan dengan cara meningkatkan kadar hemoglobin, salah satunya yaitu dengan mengkonsumsi sari kurma yang dapat meningkatkan kadar hemoglobin. Tujuan: Penelitian ini adalah mengetahui efektivitas sari kurma terhadap peningkatan kadar hemoglobin pada ibu nifas di wilayah UPT Puskesmas Kereng Bangkirai Tahun 2020. Metode penelitian yang digunakan yaitu Pre Eksperimental, One Group Pretest – Posttest design (satu kelompok pretest – posttest). Teknik pengambilan sampel yang digunakan yaitu Consecutive Sampling dengan sampel sebanyak 30 responden yang sudah memenuhi atau sesuai dengan kriteria inklusi. Uji statistik yang digunakan adalah uji T-Paired. Hasil yaitu kadar hemoglobin ibu nifas sebelum diberikan intervensi terendah yaitu 9.0 gr% dan tertinggi yaitu 11.7gr%, kemudian sesudah diberikan intervensi, kadar hemoglobin terendah pada ibu nifas yaitu 11.8gr% dan tertinggi yaitu 14.7gr%. Pada uji T, didapatkan nilai p-value sebesar 0,000 atau p-value < α (0,005), ini menunjukkan bahwa ada pengaruh atau efektivitas sebelum dan sesudah pemberian sari kurma terhadap peningkatan kadar hemoglobin pada ibu nifas. Kesimpulan: Terdapat efektivitas sebelum dan sesudah pemberian sari kurma terhadap peningkatan kadar hemoglobin pada ibu nifas di wilayah UPT Puskesmas Kereng Bangkirai Kota Palangka Raya.
Effectiviness Of Sari Palm (Phoenix Dactylivera) On Improving Pregnant Women Hemoglobin Levels On Trimester III
Authors: Yuniarti Yuniarti , Yanti Fatma 
Published: July 2020

Abstract
Background: WHO reports that the prevalence of pregnant women with iron deficiency is around 35-75% and increases with increasing gestational age. This clearly raises the risk of maternal death, prematurity, low birth weight, and increased perinatal mortality.
Objective: To determine the effect of dates palm juice administration on the increase in hemoglobin levels in pregnant women.
Method: The experimental research design in this study was the One Group Pre-test and Post-test design. The population in this study were all TM III pregnant women in the Palangka Raya Midwife Independent Practice in January-March 2020. Samples were TM III pregnant women in January-March 2020 who met the inclusion and exclusion criteria of 27 respondents with consecutive sampling. The statistical test used is the Paired T-Test.
Results: 21 people (70%) had high school education, aged 20-35 years (21%) (70%), and 30 people (> 23.5 cm) of lila size were 30 people (100%). There was a significant difference (p = 0.29). Conclusion: There is an effect of an increase in hemoglobin levels in TM III pregnant women after being given palm juice.
SYNCHRONIZATION OF EPILEPTIFORM ACTIVITY BETWEEN CA1 AND CA3 HIPPOCAMPAL FIELDS UNDER SYNAPTIC AND NON-SYNAPTIC CONDITIONS IN RAT BRAIN SLICES
Authors: Zapukhliak O.S. , Netsyk O.V. , Isaev D.S. 
Published: July 2020

Relevance. Over-synchronization of neuronal activity results in epileptic-like discharges that can lead to seizures and status epilepticus. Understanding mechanisms of neural net synchronization could provide new insights into the treatment of epileptic disorders.
Objective: to compare the levels of synchronization between CA3 and CA1 hippocampal zones during epileptiform activity induced under synaptic and non-synaptic conditions.
Materials and Methods. Transverse brain slices were obtained from 12-14 days old rats. For induction of epileptiform activity common pro-epileptic agents were used: bicuculline and 4-aminopiridine. Nonsynaptic epileptiform activity was induced by perfusion brain slices with low-Ca2+ and Cd2+-containing artificial cerebrospinal fluid (aCSF). Simultaneous extracellular recordings of field potentials were obtained from the CA3 and CA1 pyramidal cell layer with extracellular glass microelectrodes (2–3 MΩ). Signals were then low-pass filtered (kHz), amplified using a 2-channel differential amplifier M1800, digitized at 10 kHz using analog-to-digital converter. The level of synchronization between CA3 and CA1 was evaluated using cross-correlation analysis.
Results: Perfusion hippocampal slices with bicuculline and 4-aminopyridine induced epileptiform activity with high level of synchronization between CA3 and CA1 hippocampal zones. Removing Ca2+ from extracellular solution as well as adding CdCl2 to the perfusion aCSF induced epileptiform activity that was not synchronized between hippocampal CA3 and CA1 fields.
Conclusions: Synaptic interaction account for high level of CA3-CA1 synchronization induced by pro-epileptic agents bicuculline and 4-aminopiridine. Under non-synaptic conditions, local cellular interactions induce epileptiform activity with no synchronization between CA3 and CA1 hippocampal zones.