bluuebunny/crossref_metadata_2025_split huggingface dataset:
Domestication et reproduction chez les poissons
Authors: FOSTIER A. , JALABERT B. 
Published: May 2020

La demande de diversification des produits piscicoles conduit à mettre en élevage et domestiquer de nouvelles espèces de poissons. Une des étapes de cette domestication vise à maîtriser la reproduction, à un niveau de sophistication qui peut d’ailleurs varier selon le degré d’intensification du système d’élevage. Une réflexion sur la rationalisation de cette démarche conduit à explorer trois types de questions : Quelle maîtrise de la reproduction pour les espèces d’élevage actuelles ? Comment extrapoler les connaissances acquises d’une espèce à une autre ? Quelles sont les caractéristiques de reproduction les plus intéressantes à prendre en compte dans le processus de sélection-domestication ?
La réponse à la première question montre des niveaux de contrôle de la reproduction très variables selon les espèces. Ceci tient à la diversité de l’état des connaissances, des disponibilités en juvéniles sauvages et des choix techniques aujourd’hui économiquement viables.
La seconde question soulève le problème des classifications et typologies génétiques et phénotypiques disponibles et de leur exploitation. Les bases de données qui se développent permettent de proposer des phylogénies s’appuyant sur la connaissance du génome et de son expression, mais le couplage avec des bases de données, aussi riches et codifiées, portant sur les caractères phénotypiques des espèces considérées reste encore un enjeu dans une démarche in silico de biologie comparée.
Dans un objectif utilitaire, la réponse à la troisième question peut guider les choix à faire parmi les différents traits caractérisant une stratégie de reproduction, ceci pour orienter la recherche de certaines convergences biologiques et les extrapolations de techniques d’une espèce à une autre.
AKTUALISASI KETELADANAN GURU SEBAGAI UPAYA MEWUJUDKAN PENDIDIKAN BERKARAKTER DI SEKOLAH DASAR
Authors: Suyahman Suyahman 
Published: May 2020

<p>Penelitian ini bertujuan mendeskripsikan aktualisasi keteladanan guru sebagai upaya mewujudkan pendidikan berkarakter di Sekolah Dasar Negeri Pucangan 3 Kecamatan Kartasura Kabupaten Sukoharjo. Subjek penelitiannya : guru dan siswa SD Negeri pucangan 3, objeknya keteladanan guru dan pendidikan berkarakter. Jenis penelitian ini , penelitian kualitatif dengan pendekatan deskriptif. Metode pengumpulan datanya: observasi, wawancara dan dokumentasi. Guna mengetahui validitas data digunakan triangulasi data dan metode. Teknik analisis datanya menggunakan teknik analisis interaktif mengalir yang terdiri dari 3 langkah yaitu reduksi data, display data dan verifikasi data. Hasil penelitian : berdasarkan hasil observasi dan wawancara ditemukan bahwa sikap, perilaku, dan perbuatan nyata guru menjadi contoh bagi para siswa di SD negeri pucangan 3. Karena itu guru diharuskan untuk bersikap, berperilaku dan berbuat yang baik terlebih dahulu sebelum memberikan saran dan nasehat bagi para siswa dalam bersikap, berperilaku dan berbuat baik di lingkungan sekolah, masyarakat maupun lingkungan keluarga. Khusus dalam lingkungan sekolah sikap, perilaku dan perbuatan guru harus dapat dicontoh oleh para siswa, misalnya cara berpakaian, cara minum, cara bicara/berkomunikasi, cara makan, dan lain-lain. Kesimpulannya bahwa keteladanan guru memiliki peran penting dalam mewujudkan pendidikan berkarakter di SD negeri Pucangan 3, Kecamatan Kartasura, Kabupaten Sukoharjo.</p><p> </p><strong>Kata- Kunci: </strong>Aktualisasi Keteladanan Guru dan Pendidikan Berkarakter
Exploring characteristics of COPD patients with clinical improvement after integrated disease management or usual care: post-hoc analysis of the RECODE study
Authors: Meijer Eline , Eeden Annelies E. van , Kruis Annemarije L. , Boland Melinde R.S. , Assendelft W. J.J. (Pim) , Tsiachristas Apostolos , Mölken Maureen P.M.H. Rutten-van , Kasteleyn Marise J. , Chavannes Niels H. 
Published: May 2020

Abstract
Background: The cluster randomized controlled trial on (cost-)effectiveness of integrated chronic obstructive pulmonary disease (COPD) management in primary care (RECODE) showed that integrated disease management (IDM) in primary care had no effect on quality of life (QOL) in COPD patients compared with usual care (guideline-supported non-programmatic care). It is possible that only a subset of COPD patients in primary care benefit from IDM. We therefore examined which patients benefit from IDM, and whether patient characteristics predict clinical improvement over time.Method: Post-hoc analyses of the RECODE trial among 1086 COPD patients. Logistic regression analyses were performed with baseline characteristics as predictors to examine determinants of improvement in QOL, defined as a minimal decline in Clinical COPD Questionnaire (CCQ) of 0.4 points after 12 and 24 months of IDM. We also performed moderation analyses to examine whether predictors of clinical improvement differed between IDM and usual care.Results: Regardless of treatment type, more severe dyspnea (MRC) was the most important predictor of clinically improved QOL at 12 and 24 months, suggesting that these patients have most room for improvement. Clinical improvement with IDM was associated with female gender (12-months) and being younger (24-months), and improvement with usual care was associated with having a depression (24-months).Conclusions: More severe dyspnea is a key predictor of improved QOL in COPD patients over time. More research is needed to replicate patient characteristics associated with clinical improvement with IDM, such that IDM programs can be offered to patients that benefit the most, and can potentially be adjusted to meet the needs of other patient groups as well.Trial registration: Netherlands Trial Register, NTR2268. Registered 31 March 2010, https://www.trialregister.nl/trial/2144.
Evaluating effectiveness of screening house eaves as a potential intervention for reducing indoor vector densities and malaria prevalence in Nyabondo, western Kenya .
Authors: NG'ANG'A PETER N. , Okoyo Collins , Mbogo Charles , Mutero Clifford Maina 
Published: May 2020

Abstract
Background: Mosquito-proofing of houses using wire mesh screens is gaining greater recognition as a practical intervention for reducing exposure to malaria transmitting mosquitoes. Screening potentially protects all persons sleeping inside the house against transmission of mosquito-borne diseases indoors. The study assessed the effectiveness of house eaves screening in reducing indoor vector densities and malaria prevalence in Nyabondo, western Kenya. Methods: 160 houses were selected for the study, with half of them randomly chosen for eaves screening with fibre-glass coated wire mesh (experimental group) and the other half left without screening (control group). Randomization was carried out by use of computer-generated list in permuted blocks of ten houses and 16 village blocks, with half of them allocated treatment in a ratio of 1:1. Cross-sectional baseline entomological and parasitological data were collected before eave screening. After baseline data collection, series of sampling of indoor adult mosquitoes were conducted once a month in each village using CDC light traps. Three cross-sectional malaria parasitological surveys were conducted at three month intervals after installation of the screens. The primary outcome measures were indoor Anopheles mosquito density and malaria parasite prevalence. Results: A total of 15,286 mosquitoes were collected over the two years period using CDC light trap in 160 houses distributed over 16 study villages (mean = 4.35, SD = 11.48). Of all mosquitoes collected, 2,872 were anophelines (2,869 An. gambiae s.l., 1 An. funestus and 2 other Anopheles spp ). Overall, among An. gambiae collected, 92.6% were non-blood fed, 3.57% were blood fed and the remaining 0.47% were composed of gravid and half gravid females. More indoor adult mosquitoes were collected in the control than experimental arms of the study. Results from cross-sectional parasitological surveys showed that screened houses recorded relatively low malaria parasite prevalence rates compared to the control houses. Overall, malaria prevalence was 5.6% (95%CI: 4.2-7.5) n=1,918, with baseline prevalence rate of 6.1% (95%CI: 3.9-9.4), n=481 and 3 rd follow-up survey prevalence of 3.6% (95%CI: 2.0-6.8) n=494. At all the three parasitological follow-up survey points, house screening significantly reduced the malaria prevalence by 100% (p<0.001), 63.6% (p=0.026), and 100% (p<0.001) in the 1 st , 2 nd and 3 rd follow-up surveys respectively. Conclusions: The study demonstrated that house eave screening has potential to reduce indoor vector densities and malaria prevalence in high transmission areas.
Community Memory Screening as a Strategy for Recruiting Older Adults into Alzheimer’s Disease Research
Authors: Peavy Guerry M. , Jenkins Cecily W. , Little Emily A. , Gigliotti Christina , Calcetas Amanda , Edland Steven D. , Brewer James B. , Galasko Douglas , Salmon David P. 
Published: May 2020

Abstract
Background Growing awareness of Alzheimer’s disease (AD) has prompted a demand for quick and effective ways to screen for memory loss and cognitive decline in large numbers of individuals in the community. Periodic Memory Screening Day events provide free, brief cognitive screening aimed at those 65 years and older, and can serve as an opportunity to gauge participants’ attitudes towards AD research and recruit them into ongoing research projects. Methods Over 6 single-day events in 2 years, more than 574 individuals were individually screened using the MoCA and a story recall task (immediate and delayed), given feedback about their performance, and introduced to AD research and opportunities to participate. Results Screening classified 297 individuals (52.0%) as having “ No Decline ”, 192 (33.6%) as “ Possible decline ” and 82 (14.4%) as “ Likely decline ”. Those with “ Likely decline ” were older and less educated, had more memory concerns, were more likely to be men, and were less likely to have a positive family history of dementia than those with “ No Decline ”. Subsequent validation of screening procedures against a full clinical evaluation showed 72% classification accuracy with a skew towards over-calling Possible and Likely decline and thereby guiding questionable individuals to a more thorough evaluation. Of those screened, 378 (66%) agreed to additional research and consented to being listed in a research registry; and a majority (70-85%) of those consenting reported they were amenable to various AD research procedures including lumbar puncture, MRI and autopsy. Overall, 19.1% of those screened met inclusion criteria for ongoing studies and were successfully recruited into AD research. Conclusions Conducting a few concentrated community memory screening events each year may help meet the public’s demand for brief assessment of memory concerns and can be a relatively effective and efficient recruitment strategy for AD research.
Psychometric properties of a Chinese version of the Fraboni Scale of Ageism: evidence from medical students sample
Authors: Fan Jun-Yao , Zhao Hui-Min , Liu Yue-Ting , Kong Ling-Lin , Mao Jing , Li Jie 
Published: May 2020

Abstract
Background The increasing of older adults has led to enormous demand for medical care. However, as a group with unique needs and characteristics, older adults are often discriminated against in the medical field. In this paper, we aimed to translate the Fraboni Scale of Ageism (FSA) into Chinese and examine its construct validity, content validity, and reliability in Chinese mainland medical students. In order to evaluate the prevalence of ageism in Chinese medical students and prompt medical college to adopt necessary teaching methods to mitigate ageism in medical students. Methods By Brislin's translation guidelines, FSA was translated to Chinese. The convenient sampling method was used to select samples for this survey, including 1,974 students from two medical schools in central and north China. Construct validity was verified by the exploratory and confirmatory factor analysis. The content validity index (CVI) was used to assess content validity. The Cronbach's alpha coefficients and intraclass correlation coefficient (ICC) were used to estimate reliability. Results The alpha coefficients for FSA (Chinese version) was 0.81 and ICC was 0.87. The CVI was 0.93. Three factors were identified by exploratory factor analysis explaining 34.84% of the total variance and a three-factor model was confirmed to fit by confirmatory factor analysis. Conclusions FSA (Chinese version) is a reliable and valid scale for measuring discrimination degree against the older adults in Chinese medical students.
Experiences and Needs Concerning Health Related Information for Newly Arrived Refugees in Sweden
Authors: Mårtensson Lena , Lytsy Per , Westerling Ragnar , Wångdahl Josefin 
Published: May 2020

Abstract
Background Owing to communication challenges and a lack of knowledge about the health care system, refugees may be at risk of having limited health literacy, meaning that they will have problems in achieving, understanding, appraising and using health information or navigating in the health care system. The aim of this study was to explore experiences and needs concerning health related information for newly arrived refugees in Sweden. Methods A qualitative design with a focus group methodology was used. The qualitative content analysis was based on seven focus group discussions, including 28 Arabic and Somali speaking refugees. Results Four categories emerged. ‘Concrete instructions and explanations’ includes appreciation of knowledge about how to act when facing health problems. ‘Contextual knowledge’ comprises experienced needs of information about the health care system, about specific health risks and about rights in health issues. ‘A variation of sources’ describes suggestions as to where and how information should be given. ‘Enabling communication’ includes the wish for more awareness among professionals from a language and cultural point of view. Conclusion Concrete instructions and explanations are experienced as valuable and applicable. Additional information about health issues and the health care system is needed. Information concerning health should be spread by a variety of sources. Health literate health organizations are needed to meet the health challenges of refugees, including professionals that emphasize health literacy.
Assessment of dynamic balancing responses following perturbations during slow walking in relation to clinical outcome measures for high-functioning post-stroke subjects
Authors: Zadravec Matjaž , Olenšek Andrej , Rudolf Marko , Bizovičar Nataša , Goljar Nika , Matjacic Zlatko 
Published: May 2020

Abstract
Background : Generating appropriate balancing reactions in response to unexpected loss of balance during walking is important to prevent falls. The purpose of this study was to assess dynamic balancing responses following pushes to the pelvis in groups of post-stroke and healthy subjects. Methods : Forty-one post-stroke subjects and forty-three healthy subjects participated in the study. Dynamic balancing responses to perturbations triggered at heel strike of the left or right leg, directed in the forward, backward, inward and outward directions during slow treadmill walking were assessed. Responses of the healthy group provided reference values used to classify responses of the post-stroke group into two subgroups; one within the reference responses (“inside” subgroup) and the other that falls out (“outside” subgroup). A battery of selected clinical outcome measures (6-Minute Walk Test, 10-Meter Walk Test, Timed-Up-and-Go test, Four Square Step Test, Functional Gait Assessment, Functional Independence Measure and One-legged stance test) was additionally assessed in the post-stroke group. Results : The “inside” subgroup of post-stroke subjects was able to appropriately modulate centre-of-pressure and ground-reaction-force both under the impaired and non-impaired leg in response to perturbations. The “outside” subgroup of post-stroke subjects showed limited modulation of centre-of-pressure and ground-reaction-force under the impaired leg; instead a stepping strategy was used in which the non-impaired leg was placed such as to make a longer step (forward perturbation), to make a shorter step (backward perturbation) or to make a cross-step (outward perturbation). Consequently, peak centre-of-mass displacements following perturbations were significantly higher in the “outside” subgroup compared to the “inside” subgroup. Responses in both subgroups following inward perturbations did not differ. Majority of clinical outcome measures moderately correlated with the peak centre-of-mass displacements for forward perturbations and exhibited weak correlations for other perturbation directions. Conclusions : Substantial number of post-stroke subjects, that were considered to be independent walkers, have reduced capabilities to execute appropriate balancing responses following perturbations commencing on the hemiparetic leg and may thus benefit from perturbation-based training. Selected clinical outcome measures may provide an indication on the abilities of each subject to counteract unexpected loss of balance. However, a reliable assessment should be done through perturbation-based measures.
Degradation of Emerald Green: Scientific Studies on Multi-polychrome Vairocana Statue in Dazu Rock Carvings, Chongqing, China
Authors: Li Zhimin , Wang Lele , Chen Huili , Ma Qinglin 
Published: May 2020

Abstract
The spontaneous degradation of pigments in painting may occur depending on environment, especially the surrounding condition of high humidity and soluble salts. Even some of these are well studied, more investigations are still in need for heritage science. Paint cross sections from Vairocana Statue in Dazu Rock Carvings, one of World Cultural Heritage, Chongqing, China are studied by optical microscopy (OM), Raman spectroscopy (Raman) and mapping, and scanning electron microscopy coupled with energy dispersive X-ray analysis (SEM–EDS). Ultramarine blue, emerald green, synthetic atacamite, vermilion, red lead, gold foil, orpiment, cerussite, gypsum and barite are identified as pigments. Moreover, lavendulan (NaCaCu 5 (AsO 4 ) 4 Cl·5H 2 O) and mimetite (Pb 5 (AsO 4 ) 3 Cl) are degradation products of emerald green (Cu(C 2 H 3 O 2 ) 2 ·3Cu(AsO 2 ) 2 ) and cerussite (PbCO 3 ) originally used as green pigment with mixture. These secondary products is formed via multistep progresses as degradation of emerald green and cerussite, oxidation of arsenite ((AsO 2 ) - ), migration of arsenate ((AsO 4 ) 3- ) and precipitation reaction of these ions with other necessary ions from environmental conditions. Based on the pigment and paint layer stratigraphy analysis, the paintings of the statue have been executed at least four times and the most recent may be after 1850s. The formation of lavendulan give rise to a highlight for identification of green copper-arsenic containing pigments and characterization of degradation in complex conditions.
Inhibition of Hypertrophy and Improving Chondrocyte Differentiation by MMP-13 Inhibitor Small Molecule-Encapsulated in Alginate-Chondroitin Sulfate-Platelet Lysate Hydrogel
Authors: Jahangir Shahrbanoo , Eglin David , Pötter Naomi , Ravari Mojtaba Khozaei , Stoddart Martin , Samadikuchaksaraei Ali , Alini Mauro , Eslaminejad Mohammadreza Baghaban , Safa Majid 
Published: May 2020

Abstract
Background Mesenchymal stem cells are a promising cell source for chondrogenic differentiation and have been widely used in several preclinical and clinical studies. However, they are prone to an unwanted differentiation process towards hypertrophy that limits their therapeutic efficacy. Matrix Metallopeptidase 13 (MMP-13) is a well-known factor regulated during this undesirable event. MMP-13 is a collagen degrading enzyme, which is also highly expressed in the hypertrophic zone of the growth plate and in OA cartilage. Accordingly, we investigated the effect of MMP-13 inhibition on MSC hypertrophy.Methods In this study, 5-bromoindole-2-carboxylic acid (BICA) was used as an inhibitory agent for MMP-13 expression. After identifying its optimal concentration, BICA was mixed into a hydrogel and the release rate was studied. To prepare the ideal hydrogel, chondroitin sulfate (CS) and platelet lysate (PL) were mixed with sodium alginate (Alg) at concentrations selected based on synergistic mechanical and rheometric properties. Then, four hydrogels were prepared by combining alginate (1.5%w/v), and/or CS (1%w/v) and/or PL (20%v/v). The chondrogenic potential and progression to hypertrophy of human bone marrow-derived mesenchymal stem cell (hBM-MSC) loaded hydrogels were investigated under free swelling and mechanical loading conditions, in the presence and absence of BICA.Results Viability of hBM-MSCs seeded in the four hydrogels was similar. qRT-PCR revealed that BICA could successfully inhibit MMP-13 expression, which led to an inhibition of Coll X and induction of Coll-II, in both free swelling and loading conditions. The GAG deposition was higher in the group combining BICA and mechanical stimulation.Conclusions It is concluded that BICA inhibition of MMP-13 reduces MSC hypertrophy during chondrogenesis.
Angiotensin AT1 and AT2 receptor heteromer expression in the hemilesioned rat model of Parkinson’s disease that increases with levodopa-induced dyskinesia
Authors: Rivas-Santisteban Rafael , Rodriguez-Perez Ana I. , Muñoz Ana , Reyes-Resina Irene , Labandeira-García José Luis , Navarro Gemma , Franco Rafael 
Published: May 2020

Abstract
Background/Aims: The renin-angiotensin system (RAS) is altered in Parkinson’s disease (PD), a disease due to substantia nigra neurodegeneration and whose dopamine-replacement therapy, using the precursor levodopa, leads to dyskinesias as the main side effect. Angiotensin AT1 and AT2 receptors, mainly known for their role in regulating water homeostasis and blood pressure and able to form heterodimers (AT1/2Hets), are present in the central nervous system. We assessed the functionality and expression of AT1/2Hets in Parkinson Disease (PD).Methods: Immunocytochemistry was used to analyze the colocalization between angiotensin receptors, bioluminescence resonance energy transfer was used to detect AT1/2Hets. Calcium and cAMP determination, MAPK activation and label-free assays were performed to characterize signaling in homologous and heterologous systems. Proximity ligation assays was used to quantify receptor expression in mouse primary cultures and in rat striatal sections.Results: We confirmed that AT1 and AT2 receptors form AT1/2Hets that are expressed in cells of the central nervous system. AT1/2Hets are novel functional units with particular signaling properties. Importantly, the coactivation of the two receptors in the heteromer reduces the signaling output of angiotensin. Remarkably, AT1/2Hets that are expressed in both striatal neurons and microglia show a cross-potentiation, i.e. candesartan, the antagonist of AT1 increases the effect of AT2 receptor agonists. In addition, the level of striatal expression increased in the unilateral 6-OH-dopamine lesioned rat PD model and was markedly higher in parkinsonian-like animals that did not become dyskinetic upon levodopa chronic administration if compared with expression in those that became dyskinetic.Conclusion: The results indicate that boosting the action of neuroprotective AT2 receptors using an AT1 receptor antagonist constitutes a promising therapeutic strategy in PD.