bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating tumour cell enumeration does not correlate with Miller–Payne grade in a cohort of breast cancer patients undergoing neoadjuvant chemotherapy
Authors: O’Toole Sharon A. , Spillane Cathy , Huang Yanmei , Fitzgerald Marie C. , Ffrench Brendan , Mohamed Bashir , Ward Mark , Gallagher Michael , Kelly Tanya , O’Brien Cathal , Ruttle Carmel , Bogdanska Anna , Martin Cara , Mullen Dorinda , Connolly Elizabeth , McGarrigle Sarah A. , Kennedy John , O’Leary John J. 
Published: May 2020

Abstract
Purpose
The association between pathological complete response (pCR) in patients receiving neoadjuvant chemotherapy (NAC) for breast cancer and Circulating Tumour Cells (CTCs) is not clear. The aim of this study was to assess whether CTC enumeration could be used to predict pathological response to NAC in breast cancer as measured by the Miller–Payne grading system.

Methods
Twenty-six patients were recruited, and blood samples were taken pre- and post-NAC. CTCs were isolated using the ScreenCell device and stained using a modified Giemsa stain. CTCs were enumerated by 2 pathologists and classified as single CTCs, doublets, clusters/microemboli and correlated with the pathological response as measured by the Miller–Payne grading system. χ2 or ANOVA was performed in SPSS 24.0 statistics software for associations.

Results
89% of patients had invasive ductal carcinoma (IDC) and 11% invasive lobular carcinoma (ILC). At baseline 85% of patients had CTCs present, median 7 (0–161) CTCs per 3 ml of whole blood. Post-chemotherapy, 58% had an increase in CTCs. This did not correlate with the Miller–Payne grade of response. No significant association was identified between the number of CTCs and clinical characteristics; however, we did observe a correlation between pre-treatment CTC counts and body mass index, p < 0.05.

Conclusions
Patients with a complete response to NAC still had CTCs present, suggesting enumeration is not sufficient to aid surgery stratification. Additional characterisation and larger studies are needed to further characterise CTCs isolated pre- and post-chemotherapy. Long-term follow-up of these patients will determine the significance of CTCs in NAC breast cancer patients.
Polish adaptation of the Family Resilience Assessment Scale (FRAS)
Authors: Nadrowska Natalia , Błażek Magdalena , Lewandowska-Walter Aleksandra 
Published: May 2020

AbstractFamily Assessment Resilience Scale (FRAS) by Sixbey (2005) is based on the model proposed by Walsh (1996), allows to evaluate the processes of family resilience. The main goal of this study was to adapt the English version of FRAS to the Polish population (FRAS-PL) as there is no questionnaire in Poland to assess family resilience. After the process of translation into Polish and then back to English to check the correctness, the final version was accepted and participants (N = 502, 65% female, M = 24.60, SD = 6.86) filled out the questionnaire. To obtain the best-fitting model of the tool, confirmatory factor analysis (CFA) was used. Confirmatory Factor Analysis showed that the six-factor model fits the obtained data (χ2/df = 2.95, RMSEA = 0.06, CFI = 0.92, TLI = 0.91, WRMR = 1.87). The alpha coefficients are satisfactory for all subscales (from α = 0.63 to α = 0.95). The adaptation of FRAS-PL was compared to final versions accepted in different countries and explained in the cultural context. The Polish version of the scale, named FRAS-PL, can be used for both researchers and clinicians to assess family resilience.
Nitrogen Tax and Set-Aside as Greenhouse Gas Abatement Policies Under Global Change Scenarios: A Case Study for Germany
Authors: Henseler Martin , Delzeit Ruth , Adenäuer Marcel , Baum Sarah , Kreins Peter 
Published: May 2020

AbstractThe ambitious climate policy objectives of the COP21 agreement require the design and the implementation of effective and efficient policy instruments. The effectiveness and efficiency of agricultural abatement options depend on regional climate and natural conditions, changes in the global economy, global agricultural markets and regional agricultural production. Thus, the assessment of abatement options requires consideration of the global scale, the market scale and the regional producer scale. We investigate two abatement options discussed controversially in literature. Both have been partially applied to reduce environmental pollution from agriculture: a tax on nitrogen and the obligatory set-aside of agricultural land. Our study provides an assessment of the ecological effectiveness and the economic efficiency of both abatement options under different global scenarios. In our policy analysis we combine three applied policy simulation models to develop an integrated economic model framework. This model framework considers the global, the national and the regional scale and consists of the global general equilibrium model DART-BIO, the partial-equilibrium model CAPRI and the regional supply model RAUMIS. In the different global scenarios, the results show that both abatement options create relatively high marginal abatement costs and that the maximally reached abated greenhouse gas emissions represent only 15% of the quantity required to fulfill the policy targets. Compared to the obligatory set-aside option, the nitrogen tax is in both scenarios the more efficient policy. With respect to impacts on production and environment, a nitrogen tax is less forecastable than the obligatory set-aside option. Our study illustrates the relevance of considering global economic and market change in the assessment of producer-targeting environmental policies.
First laser ions at the CERN-MEDICIS facility
Authors:   MEDICIS Collaboration, Gadelshin Vadim Maratovich , Wilkins Shane , Fedosseev Valentin Nikolaevich , Barbero Ermanno , Barozier Vincent , Bernardes Ana-Paula , Chevallay Eric , Cocolios Thomas Elias , Crepieux Bernard , Dockx Kristof , Eck Matthias , Fernier Pascale , Cavaier Roberto Formento , Haddad Ferid , Jakobi Johannes , Lambert Laura , Marsh Bruce Allan , Marzari Stefano , Ramos Joao Pedro , Moberg Annie Ringvall , Rothe Sebastian , Stora Thierry , Studer Dominik , Suarez Andres Vieitez , Weber Felix , Wendt Klaus 
Published: May 2020

AbstractThe CERN-MEDICIS facility aims to produce emerging medical radionuclides for the theranostics approach in nuclear medicine with mass separation of ion beams. To enhance the radioisotope yield and purity of collected samples, the resonance ionization laser ion source MELISSA was constructed, and provided the first laser ions at the facility in 2019. Several operational tests were accomplished to investigate its performance in preparation for the upcoming production of terbium radioisotopes, which are of particular interest for medical applications.
Closing gaps, opening doors: an experimental collaboration in stem cell intervention
Authors: Rossi Fabio , Braun Martin , Brock Jonathan , Sen-Lum Janette , Ellens Sonya , Lander Elliot , Stoddard Douglas , Cross Carolyn , Vance Angelika , Stewart Duncan , Thebaud Bernard , Illes Judy 
Published: May 2020

AbstractDespite years of warnings by the academic community that for most of the stem cell-based therapies offered in the private arena little evidence of efficacy exists, these services have been increasingly offered by Canadian private clinics. Recently, as the culmination of years of clashes between stem cell researchers and therapy providers, Health Canada issued a statement prohibiting any type of cell therapy that is not specifically approved. In this climate of conflict, a small group representing both these communities as well as the government gathered in Vancouver to identify common values, and agree on principles to move forward constructively. This historic moment demonstrated that even in this contentious space a meeting-of-minds in between researchers, clinicians, ethicists, entrepreneurs and other stakeholders is possible.
Exploring Mars with Returned Samples
Authors: Grady Monica M. 
Published: May 2020

AbstractThe international Mars Exploration community has been planning to return samples from Mars for many years; the next decade should see the plans becoming a reality. Mars Sample Return (MSR) requires a series of missions, first to collect the samples, then to return them to Earth, whilst preventing the contamination of both Earth and Mars. The first mission in the campaign, Mars 2020, will land at Jezero Crater in early 2021; samples should return to Earth sometime after 2032. The information to be derived from analysis of martian samples in terrestrial laboratories equipped with state-of-the-art instrumentation is more than recompense for the difficulties of the MSR campaign. Results from analyses of returned samples will enable increased understanding of martian geological (and possibly biological) evolution. They will facilitate preparations for human exploration of Mars and by providing a second set of absolute ages for a planetary surface will validate (or otherwise) application of the lunar crater-age scale throughout the Solar System.
On the empirical coherence and the spatiotemporal gap problem in quantum gravity: and why functionalism does not (have to) help
Authors: Linnemann Niels 
Published: May 2020

AbstractThe empirical coherence problem of quantum gravity is the worry that a theory which does not fundamentally contain local beables located in space and time—such as is arguably the case for certain approaches to quantum gravity—cannot be connected to measurements (which are actually carried out in space and time) and thus has its prospects of being empirically adequate undermined. Spacetime functionalism à la Lam and Wüthrich (Stud Hist Philos Mod Phys 64:39–51, 2018) is said to solve this empirical coherence problem as well as bridging a (putatively) severe conceptual gap between spatiotemporal structures of classical spacetime theories on the one hand, and the (so-called) non-spatiotemporal structures in quantum gravity approaches on the other hand (call this the spatiotemporal gap problem). The aim of this essay is to offer a deflationary account of both the empirical coherence problem and the spatiotemporal gap problem as they are claimed to arise at least prima facie for current theories of quantum gravity by Huggett and Wüthrich (Stud Hist Philos Mod Phys 44(3):276–285, 2013), Lam and Wüthrich (2018) and Le Bihan (Synthese 2019. https://doi.org/10.1007/s11229-019-02449-6). I defend the view that (1) spacetime functionalism is set up to address a problem (the empirical coherence problem) which can usually be solved without it; and that (2) it is wrongly claimed to (dis)solve another problem which for any actual account of quantum gravity is in fact currently non-existent anyway (the spatiotemporal gap problem).
Ethanol Steam Reforming for Hydrogen Production Over Hierarchical Macroporous Mesoporous SBA-15 Supported Nickel Nanoparticles
Authors: Parlett Christopher M. A. , Durndell Lee J. , Isaacs Mark A. , Liu Xiaotong , Wu Chunfei 
Published: May 2020

AbstractThe influence of complementary macropores, present in hierarchical macroporous mesoporous SBA-15, on the performance of supported Ni nanoparticles for ethanol steam reforming has been investigated. The increased open nature of the architecture, afforded through the incorporation of the secondary macropore network, enables superior metal dispersion. This, in turn, enhances catalytic hydrogen production performance through the generation of a greater density of active sites.
Concepts of Health-Related Quality of Life of Australian Aboriginal and Torres Strait Islander Children: Parent Perceptions
Authors: Butten Kaley , Newcombe Peter A. , Chang Anne B. , Sheffield Jeanie K. , O’Grady Kerry-Ann F. , Johnson Newell W. , King Neil , Toombs Maree 
Published: May 2020

AbstractHealth-related quality of life (HR-QoL) is a valued patient-related outcome measure. HR-QoL is typically measured using a psychometric tool. Although there are a number of general and illness-specific HR-QoL measurement tools available globally, no tool has been validated for Australian Aboriginal and/or Torres Strait Islander children. The purpose of this study was to gather Australian Aboriginal and Torres Strait Islander parent/carer perspectives of HR-QoL in children in order to inform the development of a culturally appropriate tool. Yarning circles and face to face interviews were used to document the experiences of parents and carers of Aboriginal and Torres Strait Islander children who had experienced a chronic illness. Participants were recruited through word of mouth and via established social and professional networks in Queensland and the Northern Territory of Australia. Information collected was transcribed and analysed thematically and placed into a concept map. HR-QoL was defined as more than just physical, social and psychological wellbeing. Family and social support were valued aspects of HR-QoL, as was knowledge, communication and the relationship with the health system. Participants described the importance of being heard; their voice trusted and valued by health practitioners. Racism and prejudicial behaviour had negative impacts on HR-QoL. The concepts of HR-QoL identified in this study are not included in conventional HR-QoL measurement tools. Consideration should be given to concepts proposed by Australian Aboriginal and Torres Strait Islander populations in order to adequately capture perceived HR-QoL.
Influence of crop cultivation conditions on space greenhouse equivalent system mass
Authors: Zabel Paul 
Published: May 2020

AbstractFuture crewed space missions will make use of hybrid life support systems to sustain human presence in space and on other planetary bodies. Plants fulfill essential roles in those systems such as carbon dioxide removal, oxygen production, and food production. The systems required to grow plants in space, so-called space greenhouses, are complex and need to be built as efficient as possible. Thereby, the resources mass, volume, energy, and crewtime required to grow a certain amount of food are essential because these parameters define the effectiveness of the space greenhouse. However, the required resources depend on the size of the greenhouse which in turn depends on the productivity of the crops which in turn depend on the cultivation conditions. The output of such a system can be calculated using the Modified Energy Cascade plant production model, which can simulate the food output depending on the cultivation conditions. Traditionally, life support systems are evaluated using the Equivalent System Mass method, which can determine the cost effective life support architecture for a given mission scenario. By combining both, the influence of the cultivation conditions inside the space greenhouse on the effectiveness of the complete system can be investigated. It seems counterintuitive first, but it is more effective to increase the energy per area provided to the plants in the form of light. Although that increases the electrical energy demand per area, the reduction in required cultivation area and, therefore, system size leads to a more efficient system.
Mindfulness During Pregnancy and Parental Stress in Mothers Raising Toddlers
Authors: Boekhorst Myrthe G. B. M. , Potharst Eva S. , Beerthuizen Annemerle , Hulsbosch Lianne P. , Bergink Veerle , Pop Victor J. M. , Nyklíček Ivan 
Published: May 2020

Abstract
Objectives
Parental stress has been associated with adverse child outcomes and maternal functioning. Yet, maternal factors during pregnancy that can potentially protect against later parental stress, such as mindfulness, have not been studied. Therefore, we aimed to address the possible associations between prenatal mindfulness and levels of parental stress in mothers raising toddlers.

Methods
Women in the current study (n = 165) were prospectively followed from pregnancy until 3 years after childbirth, as part of a longitudinal population based cohort (HAPPY study). At 22 weeks of pregnancy, women completed the Three Facet Mindfulness Questionnaire–Short Form (TFMQ-SF) to assess facets of mindfulness (acting with awareness, non-judging, and non-reacting). Women completed the Parenting Stress Questionnaire (PSQ) 3 years after childbirth, reporting on three components of parental stress: (1) parent-child relationship problems, (2) parenting problems, and (3) role restriction.

Results
Results of multiple linear regression analyses showed that the acting with awareness facet of mindfulness during pregnancy was a significant predictor of fewer parent-child relationship problems and parenting problems, even when adjusted for prenatal and maternal distress and child behavior problems. Higher levels of non-reacting during pregnancy were also significantly associated with fewer parenting problems in mothers raising toddlers.

Conclusions
The current study emphasizes that mindfulness during pregnancy may be a protective factor for later parental stress. More research is needed to confirm these findings and to evaluate the possible benefit of a mindfulness intervention training during pregnancy on parenting and child outcomes.
p5 Peptide-Loaded Human Adipose-Derived Mesenchymal Stem Cells Promote Neurological Recovery After Focal Cerebral Ischemia in a Rat Model
Authors: Paudyal Arjun , Ghinea Flavia Semida , Driga Mircea Popescu , Fang Wen-Hui , Alessandri Giulio , Combes Laura , Degens Hans , Slevin Mark , Hermann Dirk M. , Popa-Wagner Aurel 
Published: May 2020

AbstractAdipose-derived mesenchymal stem cells markedly attenuated brain infarct size and improved neurological function in rats. The mechanisms for neuronal cell death have previously been defined in stress states to suggest that an influx of calcium ions into the neurons activates calpain cleavage of p35 into p25 forming a hyperactive complex that induces cell death. Now we report that p5, a 24-residue peptide derived from p35, offers protection to neurons and endothelial cells in vitro. In vivo administration of human adipose-derived mesenchymal stem cells (hADMSCs) loaded with this therapeutic peptide to post-stroke rats had no effect on the infarct volume. Nevertheless, the treatment led to improvement in functional recovery in spatial learning and memory (water maze), bilateral coordination and sensorimotor function (rotating pole), and asymmetry of forelimb usage (cylinder test). However, the treatment may not impact on cutaneous sensitivity (adhesive tape removal test). In addition, the double immunofluorescence with human cell-specific antibodies revealed that the number of surviving transplanted cells was higher in the peri-infarcted area of animals treated with hADMSCs + P5 than that in hADMSC-treated or control animals, concomitant with reduced number of phagocytic, annexin3-positive cells in the peri-infarcted region. However, the combination therapy did not increase the vascular density in the peri-infarcted area after stroke. In conclusion, administration of hADMSC-loaded p5 peptide to post-stroke rats created conditions that supported survival of drug-loaded hADMSCs after cerebral ischemia, suggesting its therapeutic potential in patients with stroke.
On the Importance of Structural and Functional Fatigue in Shape Memory Technology
Authors: Frenzel Jan 
Published: May 2020

AbstractThe present work provides a brief overview on structural and functional fatigue in shape memory alloys (SMAs). Both degenerative processes are of utmost technological importance because they limit service lives of shape memory components. While our fundamental understanding of these two phenomena has improved during the last two decades, there are still fields which require scientific attention. NiTi SMAs are prone to the formation of small cracks, which nucleate and grow in the early stages of structural fatigue. It is important to find out how these micro-cracks evolve into engineering macro-cracks, which can be accounted for by conventional crack growth laws. The present work provides examples for the complexity of short crack growth in pseudoelastic SMAs. The importance of functional fatigue has also been highlighted. Functional fatigue is related to the degeneration of specific functional characteristics, such as actuator stroke, recoverable strain, plateau stresses, hysteresis width, or transformation temperatures. It is caused by the accumulation of transformation-induced defects in the microstructure. The functional stability of SMAs can be improved by (1) making phase transformations processes smoother and (2) by improving the material’s resistance to irreversible processes like dislocation plasticity. Areas in need of further research are discussed.
Planning for Distribution System with Grey Wolf Optimization Method
Authors: Ansari Muhammad Mohsin , Guo Chuangxin , Shaikh Muhammad Suhail , Chopra Nitish , Haq Inzamamul , Shen Lingbing 
Published: May 2020

AbstractNowadays Distribution generation (DG) has achieved to further precious awareness, especially inside the power system fields, so the strength and dependability specifically in the distribution system. Optimum scheduling of DG not only focuses on the size of DG only too puts a load on the optimal location of generators. Install for DG at the optimum location along with optimal size into the distribution system would improve the system performance and also give price effectual solved to the planning of the distribution network. The positive impact of optimum DG position into the distribution system would improve system voltage profile, reduction in line losses, improved power standard, make better reliability and strength of the distribution network. GWO is modeled based on the unique hunt, searching for a target, encircling target, and attacking prey, are executing to perform the optimization. The GWO is determined to the IEEE-16, 30, 57 and 118-bus test systems radial distribution network as well as considering multiplier DG units in the system. The better study outcome of the attained to without DG, with DG, type 1 DG, type 2 DG, with type 3 DG at 0.9 pf and with type DG at unity pf. Moreover, the obtained is compared as well as the net outcome of the proposed procedure for the sequence to see the efficiency and effectual and the distribution systems.
Islam and Visual Culture: Sharia Implementation and Cinema as Visual Management in Nigeria
Authors: Ibrahim Musa 
Published: May 2020

AbstractHuman experience is more visual and visualized than ever before. This has been obvious in Africa since the 1990s, when democratization, media liberalization, proliferation of small technology, and religious reform movements introduced new ways of meaning-making. Ibrahim’s ethnographic research shows how sharia implementation and cinema as cultural production in northern Nigeria are embedded within the implicit and explicit visual regime of influencing what and how people see, think, and perform. The strategic replacement of cinemas with religious or other “neutral” objects is a visual regime that shifts people’s vision or encounter from one means of cultural production to another.