bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of sleep and health-related quality of life among health care professionals treating patients with coronavirus disease-19
Authors: Stojanov Jelena , Malobabic Marina , Stanojevic Goran , Stevic Milos , Milosevic Vuk , Stojanov Aleksandar 
Published: July 2020

Background: Health care professionals exposed to coronavirus disease 2019 (COVID-19) are facing high levels of stress. Aim: The aim was to evaluate the quality of sleep (QoS) and health-related quality of life (HRQoL), among health care professionals treating patients with COVID-19, as well as quantifying the magnitude of symptoms of depression and levels of anxiety. Methods: We included 201 health care professionals in a cross-sectional, web-based study by applying 7-item Generalized Anxiety Disorder (GAD-7) Scale, Zung Self-rating Depression Scale, 36-item Health Survey of the Medical Outcomes Study Short Form (SF36), Pittsburgh Sleep Quality Index (PSQI) and additional survey constructed for the purpose of the study. Results: Health care workers who treated COVID-19 patients were more afraid of becoming infected or of transmitting the infection to a family member with a significantly low self-assessment of their mental status. Poor QoS and HRQoL correlated with high health anxiety and severe depressive symptoms and several demographic characteristics. Multiple linear regression analysis showed that higher scores on GAD-7 (beta = .71, p < .01) and lower scores on mental health (MH) subscale on SF36 questionnaire (beta = –.69; p < .01) were independent predictors of the higher PSQI score (adjusted R2 = .61, p < .01 for overall model). Higher scores on GAD-7 (beta = .68, p < .01) and worse self-perceived mental status (beta = .25; p < .05) were independent predictors of the lower SF36 scores (adjusted R2 = .73, p < .01 for overall model). Conclusion: The major MH burden of health care professionals treating infected patients during the COVID-19 pandemic indicates that they need psychological support.
Diagnostic efficacy of contrast-enhanced breast MRI versus X-ray mammography in women with different degrees of breast density
Authors: Barkhausen Jörg , Bischof Arpad , Haverstock Daniel , Klemens Mark , Brueggenwerth Guenther , Weber Olaf , Endrikat Jan 
Published: July 2020

Background Detection of breast cancer in women with high breast densities is a clinical challenge. Purpose To study the influence of different degrees of breast density on the sensitivity of contrast-enhanced breast magnetic resonance imaging (CE-BMRI) versus X-ray mammography (XRM). Material and Methods We performed an additional analysis of two large Phase III clinical trials (G1; G2) which included women with histologically proven breast cancers, called “index cancers.” Additional cancers were detected during image reading. We compared the sensitivity of CE-BMRI and XRM in women with different breast densities (ACR A→D; Version 5). For each study, six blinded readers evaluated the images. Results are given as the “Median Reader.” Results A total of 774 patients were included, 169 had additional cancers. While sensitivity of CE-BMRI for detecting all index cancers was independent of breast density (ACR A→D) (G1: 83%→83%; G2: 91%→91%) the sensitivity of XRM declined (ACR A→D) (G1: 79%→62%; G2: 82%→64%). Thus, the sensitivity difference between both imaging modalities in ACR A breasts of 3% (G1) and 9% (G2) increased to 21% (G1) and 26% (G2) in ACR D breasts. Sensitivity of CE-BMRI for detecting at least one additional cancer increased with increasing breast density (ACR A→D) (G1: 50%→73%, G2: 57%→81%). XRM’s sensitivity decreased (G1: 34%→20%) or remained stable (G2: 24%→25%). Conclusion CE-BMRI showed significantly higher sensitivity compared to XRM.
Bempedoic Acid: A New Drug for an Old Problem
Authors: Nguyen Dat , Du Nathan , Sulaica Elisabeth M. , Wanat Matthew A. 
Published: July 2020

Objective: To review the pharmacology, pharmacokinetics, safety, and efficacy of bempedoic acid for low-density lipoprotein cholesterol (LDL-C) reduction. Data Sources: A PubMed search was conducted from January 2000 to June 15, 2020, using the keyword bempedoic acid for phase III clinical trials published in the English language. Study Selection and Data Extraction: Articles related to the Food and Drug Administration (FDA) approval of bempedoic acid and other trials relating to the safety and efficacy of this drug were included. Data Synthesis: The findings from this review show that bempedoic acid is a safe and effective option for lowering LDL-C levels in patients requiring LDL-C lowering for primary or secondary prevention of cardiovascular events. Relevance to Patient Care and Clinical Practice: Statin therapy remains the mainstay of treatment for both primary and secondary prevention. However, many patients cannot tolerate statin therapy because of statin-associated muscle symptoms. Bempedoic acid may be a reasonable adjunct for LDL-C reduction, though further evaluation of cardiovascular outcomes with bempedoic acid in this population is needed. Conclusions: The recent FDA approval of bempedoic acid offers an additional option for lowering LDL-C levels in patients with atherosclerotic cardiovascular disease or heterozygous familial hyperlipidemia. Additional data regarding effect on long-term cardiovascular outcomes with bempedoic acid are currently being studied.
Helicobacter Pylori cagA+ Genotype is Associated With Consumption of Untreated Drinking Water in North-Eastern Brazil
Authors: Alves de Oliveira Serra Maria Aparecida , Lima Victor Pereira , Santos Carlos Alberto Andrade Serra dos , Moura de Araújo Márcio Flávio 
Published: July 2020

Introduction: This study aimed to identify the Helicobacter pylori cagA+ genotype prevalent in a region of north-eastern Brazil and find possible associations between this genotype and socioeconomic variables. Methods: This cross-sectional study included 751 patients with dyspepsia from a public endoscopy clinic. Genotyping was carried out on 98 samples from gastric tissue with positive urease test for H. pylori using polymerase chain reaction (PCR). Socioeconomic variables were collected via forms. Pearson’s χ2 test was used to analyze associations between variables and odds ratios were obtained to compare effects. Statistical significance was defined as p < 0.05 for univariate and multivariate analyses. Results: H. pylori infection was present in 52.7% of the patients and associated with low income and consumption of untreated drinking water. The prevalence of the cagA+ genotype was 25.5%. Low income was inversely related to the presence of cagA+ genotype, even after adjustment. Untreated drinking water consumption was associated with the presence of the cagA+ genotype in both the univariate ( p = 0.03; OR = 2.55; 95% CI: 1.008–6.48) and multivariate ( p = 0.03; OR = 2.89; 95% CI: 1.08–7.67) analyses. Conclusion: The findings of this study suggest that water can be an important vehicle for the transmission of pathogenic H. pylori strains and may be a public health challenge, especially in less developed regions with precarious water and sanitary conditions.
Postoperative acetabular component position in revision hip arthroplasty: a comparison of the anterior and posterior approaches
Authors: Wilson Jacob M , Schwartz Andrew M , Farley Kevin X , Anastasio Albert T , Bradbury Thomas L , Guild George N 
Published: July 2020

Background: While previously considered unsuitable for revision total hip arthroplasty (rTHA), the direct anterior approach (DAA) can be extended to allow for safe acetabular component revision. In primary hip arthroplasty, the DAA and its associated fluoroscopy, has been shown to produce more acceptable component positioning. However, there is little data comparing the DAA to the posterior approach (PA) for rTHA. We hypothesised that, the DAA with intraoperative fluoroscopy would allow for more precise acetabular component positioning when compared to those performed using a PA. Methods: 50 consecutive patients (25 DAA and 25 PA) undergoing rTHA were included. Radiographic analysis of postoperative acetabular component position was then performed. Univariate and multivariate analyses was performed to assess the contribution of approach on cup positioning inside classically defined “safe zones”. Results: Baseline patient characteristics were similar. The PA was associated with more cups placed outside the Lewinnek (48% vs. 12%, p = 0.005) and the Danoff (52% vs. 28%, p = 0.083) “safe zones” when compared to the DAA. Multivariate analysis revealed that operative approach was the only patient or surgical factor associated with component position outside of the “safe zones” (Lewinnek [OR = 13.6; 95% CI, 2.12–87.9, p = 0.006] and Danoff [OR = 7.7; 95% CI, 1.48–40.1, p = 0.015]). Conclusion: Our results suggest that the DAA allows for more reproducible and precise cup placement in RTHA. The safe-zone paradigm remains a useful index of accurate cup positioning and the DAA, with use of intraoperative fluoroscopy, offers more consistent acetabular component positioning when compared to the PA.
‘Creating health’: evaluation of three arts for health training events for GP trainees
Authors: Ellis Vivien , Tully Katherine , Gill Nicola , McLewin Angus , Clift Stephen 
Published: July 2020

Background: General practitioners (GPs) and other health professionals have a key role in signposting their patients to appropriate opportunities for engaging in arts and creative activities for the health and wellbeing benefits they may bring. Training is needed to ensure that GPs are aware of the evidence supporting the role of the arts, and the local availability of ‘creative arts for health’ activities for their patients. Aim: This article describes the content and evaluation of three arts and health training events for trainee GPs conducted over the period 2016–2019. They took place in association with Guy’s and St Thomas, Hillingdon and York and Scarborough General Practice Vocational Training Schemes (GPVTS). Methods: Evaluation was undertaken for the London events using a specially constructed questionnaire, with rating scales, completed before and after the training events. For the York event, a simple bespoke evaluation questionnaire was employed at the end of the training day. All participants gave consent for photography and filming during the events. Results: Feedback from GPs on the training events revealed increased awareness of the evidence for arts and health interventions, and more positive attitudes towards the role of creative arts in primary care in promoting the health and wellbeing of patients. An additional finding was a recognition by GP trainees that creative activities can enhance a holistic approach to patient care and play a positive part in supporting their own wellbeing. Conclusion: Training events of the kind described, with opportunities for creative participation for GP trainees, can enhance awareness of the benefits of creative activity for patient health and wellbeing, and may motivate future GPs to signpost patients towards opportunities for engaging in creative activities. This training model is applicable for any health worker who can refer patients to arts for health activities and has potential to be scaled up nationally.
MEESSI-AHF risk score performance to predict multiple post-index event and post-discharge short-term outcomes
Authors: Rossello Xavier , Bueno Héctor , Gil Víctor , Jacob Javier , Javier Martín-Sánchez Francisco , Llorens Pere , Herrero Puente Pablo , Alquézar-Arbé Aitor , Raposeiras-Roubín Sergio , López-Díez M Pilar , Pocock Stuart , Miró Òscar 
Published: July 2020

Abstract

Background
The multiple estimation of risk based on the emergency department Spanish score in patients with acute heart failure (MEESSI-AHF) is a risk score designed to predict 30-day mortality in acute heart failure patients admitted to the emergency department. Using a derivation cohort, we evaluated the performance of the MEESSI-AHF risk score to predict 11 different short-term outcomes.

Methods
Patients with acute heart failure from 41 Spanish emergency departments (n=7755) were recruited consecutively in two time periods (2014 and 2016). Logistic regression models based on the MEESSI-AHF risk score were used to obtain c-statistics for 11 outcomes: three with follow-up from emergency department admission (inhospital, 7-day and 30-day mortality) and eight with follow-up from discharge (7-day mortality, emergency department revisit and their combination; and 30-day mortality, hospital admission, emergency department revisit and their two combinations with mortality).

Results
The MEESSI-AHF risk score strongly predicted mortality outcomes with follow-up starting at emergency department admission (c-statistic 0.83 for 30-day mortality; 0.82 for inhospital death, P=0.121; and 0.85 for 7-day mortality, P=0.001). Overall, mortality outcomes with follow-up starting at hospital discharge predicted slightly less well (c-statistic 0.80 for 7-day mortality, P=0.011; and 0.75 for 30-day mortality, P&lt;0.001). In contrast, the MEESSI-AHF score predicted poorly outcomes involving emergency department revisit or hospital admission alone or combined with mortality (c-statistics 0.54 to 0.62).

Conclusions
The MEESSI-AHF risk score strongly predicts mortality outcomes in acute heart failure patients admitted to the emergency department, but the model performs poorly for outcomes involving hospital admission or emergency department revisit. There is a need to optimise this risk score to predict non-fatal events more effectively.
The Impact and Perception of Cell Phone Usage in a Teaching Hospital Setting
Authors: Caminiti Courtney , Deng Lily , Greenberg Patricia , Scolpino Anthony , Chen Catherine , Yang Ellen , Oleske James M 
Published: July 2020

Objective: To evaluate perceptions regarding cell phone use in a teaching hospital setting among health care providers, residents, medical students, and patients. Methods: Fifty-three medical students, 41 resident physicians, 32 attending physicians, and 46 nurses working at University Hospital completed a questionnaire about cell phone use practices and their perceptions of cell phone use in the hospital. Forty-three inpatients admitted to medical/surgical units at University Hospital were surveyed at bedside about their perceptions regarding physicians’ cell phone use. Results: All health care providers identified cell phones as a risk to patient confidentiality with no specific group significantly more likely to attribute risk than another. Practitioners were identified as either primarily as inpatient or outpatient practitioners. Inpatient practitioners were significantly more likely to rate cell phones as beneficial to patient care than outpatient practitioners. Physicians were statistically more likely to rate mobile phones as beneficial to patient care as compared to nurses. Among the patient population surveyed, one quarter noted that their physician had used a cell phone in their presence. The majority of those patients observing practitioner cell phone use had reported a beneficial or neutral impact on their care. Significance: Perceived risk of cell phones to patient confidentiality was equal across health care providers surveyed. Physician and medical students were significantly more likely to rate cell phones as beneficial to patients’ care than nurse providers. Patients indicated that their physicians used cell phones in their presence at low rates and reported that the use was either neutral or beneficial to the care they received.
Lenalidomide/rituximab induces high molecular response in untreated follicular lymphoma: LYSA ancillary RELEVANCE study
Authors: Delfau-Larue Marie-Helene , Boulland Marie-Laure , Beldi-Ferchiou Asma , Feugier Pierre , Maisonneuve Hervé , Casasnovas Rene-Olivier , Lemonnier François , Pica Gian Matteo , Houot Roch , Ysebaert Loic , Tilly Hervé , Eisenmann Jean-Claude , Le Gouill Steven , Ribrag Vincent , Godmer Pascal , Glaisner Sylvie , Cartron Guillaume , Xerri Luc , Salles Gilles André , Fest Thierry , Morschhauser Franck 
Published: July 2020

Abstract
Complete molecular response (CMR) after first-line immunochemotherapy reflects treatment efficacy and may predict prognosis in patients with follicular lymphoma (FL). RELEVANCE is the first phase 3 trial comparing the chemotherapy-free regimen lenalidomide/rituximab (R2) vs rituximab/chemotherapy (R-Chemo) in previously untreated FL patients (ClinicalTrials.gov identifier: NCT01650701). The objective of the minimal residual disease (MRD) analysis was to determine the ability of a chemotherapy-free regimen to induce CMR. Of 440 French patients participating in the Lymphoma Study Association (LYSA) RELEVANCE MRD study, all 222 patients with a BIOMED-2–detectable BCL2-JH translocation at diagnosis were analyzed. MRD was quantified by droplet digital polymerase chain reaction with a sensitivity ≤10−4. At week 24 (end of induction treatment), 98% and 78% of patients achieved CMR in peripheral blood (PB) and bone marrow (BM), respectively. Achievement of CMR (in PB and/or BM) had a significant impact on progression-free survival (PFS), with 3-year PFS of 84% and 55% for patients with CMR and detectable MRD, respectively (P = .015). CMR at week 24 was reached more frequently in the R2 arm (105/117; 90%) than in the R-Chemo arm (70/90; 77%) (P = .022). The poor prognostic value in terms of PFS for the persistence of molecular disease was observed irrespective of treatment arm (interaction test, P = .31). In agreement with the clinical results of the RELEVANCE trial, our results show that R2 immunomodulatory treatment in first-line FL can achieve high rates of CMR.
Cognitive and sensorimotor function in participants being treated for trigeminal neuralgia pain
Authors: Coats Rachel O. , Crossley Kirsty L. , Conlin Naomi , Wu Jianhua , Zakrzewska Joanna M. , Pavitt Sue H. , Phillips Nicholas , Mon-Williams Mark 
Published: July 2020

AbstractBackgroundTrigeminal neuralgia (TN) is an orofacial condition defined by reoccurring, spontaneous, short-lived but excruciating stabbing pain. Pharmacological interventions constitute the first-line treatment for TN, with antiepileptic drugs commonly prescribed. People treated for TN pain with antiepileptic drugs describe cognitive and motor difficulties affecting activities of daily living, and report poorer quality of life. We undertook the first comprehensive objective evaluation of sensorimotor and cognitive performance in participants being treated for TN pain with antiepileptic drugs relative to age-matched controls.MethodsParticipants (43 TN, 41 control) completed a battery of sensorimotor (steering, aiming and tracking) and cognitive (working memory, processing speed, inhibition) tasks.ResultsThe TN group performed significantly worse than controls on the sensorimotor tracking and aiming tasks and across all cognitive measures.ConclusionsThe data explain why patients treated with antiepileptic drugs report impairment when conducting activities of daily living (given the need for cognitive and motor capability within most of these). The study is an important first step in: (i) ensuring there is adequate information on the impact of pharmacological treatment; (ii) identifying measures to determine optimal medication dosage and track change over time; (iii) creating an evidence base that could allow scientific justification of alternative pain treatment options for TN (e.g. the costs/benefits of surgery).
Evaluation of fecal DNA extraction protocols for human gut microbiome studies
Authors: Lim Mi Young , Park Yong-Soo , Kim Jung-Ha , Nam Young-Do 
Published: July 2020

Abstract
Background
DNA extraction is an important factor influencing the microbiome profile in fecal samples. Considering that the QIAamp DNA Stool Mini Kit, one of the most commonly used DNA extraction kits, is no longer manufactured, this study aimed to investigate whether a new commercially available kit, the QIAamp PowerFecal Pro DNA Kit, yields comparable microbiome profiles with those previously obtained using the QIAamp DNA Stool Mini Kit.

Results
We extracted DNA from fecal samples of 10 individuals using three protocols (protocol P of the QIAamp PowerFecal Pro DNA Kit, and protocols SB and S of the QIAamp DNA Stool Mini Kit with and without an additional bead-beating step, respectively) in triplicate. Ninety extracted DNA samples were subjected to 16S rRNA gene sequencing. DNA quality measured by 260/280 absorbance ratios was found to be optimal in protocol P. Additionally, the DNA quantity and microbiome diversity obtained using protocol P were significantly higher than those of protocol S, however, did not differ significantly from those of protocol SB. Based on the overall microbiome profiles, variations between protocol P and protocol SB or S were significantly less than between-individual variations. Furthermore, most genera were not differentially abundant in protocol P compared to the other protocols, and the number of differentially abundant genera, as well as the degree of fold-changes were smaller between protocols P and SB than between protocols P and S.

Conclusions
The QIAamp PowerFecal Pro DNA Kit exhibited microbiome analysis results that were comparable with those of the QIAamp DNA Stool Mini Kit with a bead-beating step. These results will prove useful for researchers investigating the gut microbiome in selecting an alternative protocol to the widely used but discontinued kit.
Comparative transcriptomics analysis revealing flower trichome development during flower development in two Lonicera japonica Thunb. cultivars using RNA-seq
Authors: Li Jianjun , Ye Chenglin , Chang Cuifang 
Published: July 2020

AbstractBackgroundLonicera japonicaThunb. (L. japonica) has the functions of clearing away heat and detoxifying, broad-spectrum antibacterial and anti-virus, etc. More than 70% of anti-inflammatory and cold Chinese patent medicines containL. japonica. Trichomes comprise specialized multicellular structures that have the capacity to synthesize and secrete secondary metabolites and protect plants from biotic and abiotic stresses. The extraction of trichome secretions has great commercial value. However, little is known about the trichome formation mechanism inL. japonica. Therefore, the study of trichome development between different varieties provides a basis for selecting suitable planting resources.ResultsHere, we present a genome-wide comparative transcriptome analysis between twoL. japonicacultivars, toward the identification of biological processes and functional gene activities that occur during flowering stage trichome development. In this study, the density and average lengths of flower trichomes were at their highest during three-green periods (S2). Using the Illumina RNA-Seq method, we obtained 134,304 unigenes, 33,733 of which were differentially expressed. In an analysis of 40 differentially expressed unigenes (DEGs) involved in trichome development, 29 of these were transcription factors. The DEGs analysis of plant hormone signal transduction indicated that plant growth and development may be independent of gibberellin (GA) and cytokinine (CTK) signaling pathways, and plant stress may be independent of jasmonic acid (JA) and ethylene (ET) signaling pathways. We screened several genes involved in the floral biosynthesis of odors, tastes, colors, and plant hormones, and proposed biosynthetic pathways for sesquiterpenoid, triterpenoid, monoterpenoid, flavonoid, and plant hormones. Furthermore, 82 DEGs were assigned to cell cycles and 2616 were predicted as plant resistance genes (PRGs).ConclusionsThis study provides a comprehensive characterization of the expression profiles of flower development during the seven developmental stages ofL. japonica, thereby offering valuable insights into the molecular networks that underly flower development inL. japonica.