bluuebunny/crossref_metadata_2025_split huggingface dataset:
Places of living and places of dying: the case for preventing suicide in residential long-term care
Authors: Jain Briony , Kalesnikava Viktoryia , Ibrahim Joseph E. , Mezuk Briana 
Published: March 2020

AbstractThis commentary addresses the increasing public health problem of suicide in later life and presents the case for preventing suicide in residential long-term care settings. We do so by examining this issue from the perspective of three levels of stakeholders – societal, organisational and individual – considering the relevant context, barriers and implications of each. We begin by discussing contemporary societal perspectives of ageing; the potential impact of ageism on prevention of late-life suicide; and the roles of gender and masculinity. This is followed by a historical analysis of the origin of residential long-term care; current organisational challenges; and person-centred care as a suicide prevention strategy. Finally, we consider suicide in long-term care from the perspective of individuals, including the experience of older adults living in residential care settings; the impact of suicide on residential care health professionals and other staff; and the impact of suicide bereavement on family, friends and other residents. We conclude with recommendations for policy reform and future research. This commentary aims to confront the often unspoken bias associated with preventing suicide among older adults, particularly those living with complex medical conditions, and invoke an open dialogue about suicide prevention in this population and setting.
The Principles of Triage in Emergencies and Disasters: A Systematic Review
Authors: Bazyar Jafar , Farrokhi Mehrdad , Salari Amir , Khankeh Hamid Reza 
Published: March 2020

AbstractIntroduction:The use of triage systems is one of the most important measures in response to mass-casualty incidents (MCIs) caused by emergencies and disasters. In these systems, certain principles and criteria must be considered that can be achieved with a lack of resources. Accordingly, the present study was conducted as a systematic review to explore the principles of triage systems in emergencies and disasters world-wide.Methods:The present study was conducted as a systematic review of the principles of triage in emergencies and disasters. All papers published from 2000 through 2019 were extracted from the Web of Science, PubMed, Scopus, Cochrane Library, and Google Scholar databases. The search for the articles was conducted by two trained researchers independently.Results:The classification and prioritization of the injured people, the speed, and the accuracy of the performance were considered as the main principles of triage. In certain circumstances, including chemical, biological, radiation, and nuclear (CBRN) incidents, certain principles must be considered in addition to the principles of the triage based on traumatic events. Usually in triage systems, the classification of the injured people is done using color labeling. The short duration of the triage and its accuracy are important for the survival of the injured individuals. The optimal use of available resources to protect the lives of more casualties is one of the important principles of triage systems and does not conflict with equity in health.Conclusion:The design of the principles of triage in triage systems is based on scientific studies and theories in which attempts have been made to correctly classify the injured people with the maximum correctness and in the least amount of time to maintain the survival of the injured people and to achieve the most desirable level of health. It is suggested that all countries adopt a suitable and context-bond model of triage in accordance with all these principles, or to propose a new model for the triage of injured patients, particularly for hospitals in emergencies and disasters.
Knowledge of the Art of Governance: The Mughal and Ottoman Empires in the Early Seventeenth Century
Authors: SOOD GAGAN D. S. 
Published: March 2020

AbstractThis article seeks to reconstruct the prevailing concepts, images and principles that framed sovereign governance in the Mughal and Ottoman empires in the early seventeenth century. Little is known about the subject. To help fill the gap, two contemporaneous advice-to-kings treatises—one Mughal by ʿAbd al-Ḥaqq Dihlavī, one Ottoman by Koçi Bey—are analysed in juxtaposition. Such an analysis, never previously undertaken, is motivated and guided by a novel approach. In this approach, a model founded on near-universal conditions and problems is deployed within a regional perspective. The findings which result advance our understanding of the art of governance in the Mughal and Ottoman empires of the time. But they have a larger importance, too. They move us closer to achieving a break with the decline paradigm, whose logic still persists in mainstream interpretations. They also contribute to a more recent, and rapidly developing, interest in a region spanning much of South Asia and the Middle East that was formative for the global genesis of the modern world.
Age of acquisition – not bilingualism – is the primary determinant of less than nativelike L2 ultimate attainment
Authors: Bylund Emanuel , Hyltenstam Kenneth , Abrahamsson Niclas 
Published: March 2020

AbstractIt has recently been suggested that bilingualism, rather than age of acquisition, is what underlies less than nativelike attainment in childhood L2 acquisition. Currently, however, the empirical evidence in favor of or against this interpretation remains scarce. The present study sets out to fill this gap, implementing a novel factorial design in which the variables age of acquisition and bilingualism have been fully crossed. Eighty speakers of Swedish, who were either L1 monolinguals, L1 simultaneous bilinguals, L2 sequential monolinguals (international adoptees), or L2 sequential bilinguals (childhood immigrants), were tested on phonetic, grammatical, and lexical measures. The results indicate consistent effects of age of acquisition, but only limited effects of bilingualism, on ultimate attainment. These findings thus show that age of acquisition – not bilingualism – is the primary determinant of L2 ultimate attainment.
Armando Carvalho and Others v. EU: Invoking Human Rights and the Paris Agreement for Better Climate Protection Legislation
Authors: Winter Gerd 
Published: March 2020

AbstractThis contribution takes the form of an uncommon case report. It discusses an action brought to the Court of Justice of the European Union (CJEU) before the final decision has been rendered. The author believes this is justified because the innovative character of the procedural and substantive reasoning of the application could be of interest to a wider public. This may be the case even if the CJEU eventually dismisses the action as being inadmissible, leaving the substantive questions undecided. The applicants in Carvalho and Others v. European Union claim that European Union (EU) law does not limit greenhouse gas (GHG) emissions as strictly as is required by EU human rights and international law. The case note explains the parties in the case, the acts being challenged, the relief being sought, and the content and application of the relevant procedural and substantive law. The case is illustrative of the high barriers for direct access to the CJEU, and suggests how they might be overcome. It is also a laboratory for examining the interface of climate science, economics, and law. At this interface, available emissions budgets and the technical and economic feasibility of emissions reductions are calculated and made legally relevant. Carvalho is based on the applicants’ conviction that, where the EU assumes a regulatory competence such as that of GHG emissions reduction, it must exercise it in accordance with its human rights and international obligations.
The Linkage of Kuroshio Intrusion and Mesoscale Eddy Variability in the Northern South China Sea: Subsurface Speed Maximum
Authors: Wang Qiang , Zeng Lili , Chen Ju , He Yunkai , Zhou Weidong , Wang Dongxiao 
Published: March 2020

AbstractIn situ data suggest that there is a subsurface speed maximum between 70 and 120 m in the Kuroshio, which is first revealed by the directly velocity observation. The subsurface speed maximum can also be advected into the largest marginal sea in the tropics, that is, the South China Sea (SCS). As it enters the SCS, its depth shoals to between 40 and 70 m and then finally disappears in the western northern SCS. Strong subsurface speed maximum intrusion results in strong baroclinic instability, which triggers vigorous baroclinic conversion, consequently the active mesoscale eddy variability in the northern SCS, and vice versa. Our study highlights this intuitive bridge connecting the Kuroshio intrusion and the mesoscale eddy activities in the northern SCS.
Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion
Authors: Zhao Wen-Ning , Tobe Brian T. D. , Udeshi Namrata D. , Xuan Lucius L. , Pernia Cameron D. , Zolg Daniel P. , Roberts Amanda J. , Mani Deepak , Blumenthal Sarah R. , Kurtser Iren , Patnaik Debasis , Gaisina Irina , Bishop Joshua , Sheridan Steven D. , Lalonde Jasmin , Carr Steven A. , Snyder Evan Y. , Haggarty Stephen J. 
Published: March 2020

AbstractThe effective treatment of bipolar disorder (BD) represents a significant unmet medical need. Although lithium remains a mainstay of treatment for BD, limited knowledge regarding how it modulates affective behavior has proven an obstacle to discovering more effective mood stabilizers with fewer adverse side effects. One potential mechanism of action of lithium is through inhibition of the serine/threonine protein kinase GSK3β, however, relevant substrates whose change in phosphorylation may mediate downstream changes in neuroplasticity remain poorly understood. Here, we used human induced pluripotent stem cell (hiPSC)-derived neuronal cells and stable isotope labeling by amino acids in cell culture (SILAC) along with quantitative mass spectrometry to identify global changes in the phosphoproteome upon inhibition of GSK3α/β with the highly selective, ATP-competitive inhibitor CHIR-99021. Comparison of phosphorylation changes to those induced by therapeutically relevant doses of lithium treatment led to the identification of collapsin response mediator protein 2 (CRMP2) as being highly sensitive to both treatments as well as an extended panel of structurally distinct GSK3α/β inhibitors. On this basis, a high-content image-based assay in hiPSC-derived neurons was developed to screen diverse compounds, including FDA-approved drugs, for their ability to mimic lithium’s suppression of CRMP2 phosphorylation without directly inhibiting GSK3β kinase activity. Systemic administration of a subset of these CRMP2-phosphorylation suppressors were found to mimic lithium’s attenuation of amphetamine-induced hyperlocomotion in mice. Taken together, these studies not only provide insights into the neural substrates regulated by lithium, but also provide novel human neuronal assays for supporting the development of mechanism-based therapeutics for BD and related neuropsychiatric disorders.
The therapeutic response of ER+/HER2− breast cancers differs according to the molecular Basal or Luminal subtype
Authors: Bertucci François , Finetti Pascal , Goncalves Anthony , Birnbaum Daniel 
Published: March 2020

AbstractThe genomics-based molecular classifications aim at identifying more homogeneous classes than immunohistochemistry, associated with a more uniform clinical outcome. We conducted an in silico analysis on a meta-dataset including gene expression data from 5342 clinically defined ER+/HER2− breast cancers (BC) and DNA copy number/mutational and proteomic data. We show that the Basal (16%) versus Luminal (74%) subtypes as defined using the 80-gene signature differ in terms of response/vulnerability to systemic therapies of BC. The Basal subtype is associated with better chemosensitivity, lesser benefit from adjuvant hormone therapy, and likely better sensitivity to PARP inhibitors, platinum salts and immune therapy, and other targeted therapies under development such as FGFR inhibitors. The Luminal subtype displays potential better sensitivity to CDK4/6 inhibitors and vulnerability to targeted therapies such as PIK3CA, AR and Bcl-2 inhibitors. Expression profiles are very different, showing an intermediate position of the ER+/HER2− Basal subtype between the ER+/HER2− Luminal and ER− Basal subtypes, and let suggest a different cell-of-origin. Our data suggest that the ER+/HER2− Basal and Luminal subtypes should not be assimilated and treated as a homogeneous group.
A socio-environmental geodatabase for integrative research in the transboundary Rio Grande/Río Bravo basin
Authors: Plassin Sophie , Koch Jennifer , Paladino Stephanie , Friedman Jack R. , Spencer Kyndra , Vaché Kellie B. 
Published: March 2020

AbstractIntegrative research on water resources requires a wide range of socio-environmental datasets to better understand human-water interactions and inform decision-making. However, in transboundary watersheds, integrating cross-disciplinary and multinational datasets is a daunting task due to the disparity of data sources and the inconsistencies in data format, content, resolution, and language. This paper introduces a socio-environmental geodatabase that transcends political and disciplinary boundaries in the Rio Grande/Río Bravo basin (RGB). The geodatabase aggregates 145 GIS data layers on five main themes: (i) Water & Land Governance, (ii) Hydrology, (iii) Water Use & Hydraulic Infrastructures, (iv) Socio-Economics, and (v) Biophysical Environment. Datasets were primarily collected from public open-access data sources, processed with ArcGIS, and documented through the FGCD metadata standard. By synthesizing a broad array of datasets and mapping public and private water governance, we expect to advance interdisciplinary research in the RGB, provide a replicable approach to dataset compilation for transboundary watersheds, and ultimately foster transboundary collaboration for sustainable resource management.
High dielectric ternary oxides from crystal structure prediction and high-throughput screening
Authors: Qu Jingyu , Zagaceta David , Zhang Weiwei , Zhu Qiang 
Published: March 2020

AbstractThe development of new high dielectric materials is essential for advancement in modern electronics. Oxides are generally regarded as the most promising class of high dielectric materials for industrial applications as they possess both high dielectric constants and large band gaps. Most previous researches on high dielectrics were limited to already known materials. In this study, we conducted an extensive search for high dielectrics over a set of ternary oxides by combining crystal structure prediction and density functional perturbation theory calculations. From this search, we adopted multiple stage screening to identify 441 new low-energy high dielectric materials. Among these materials, 33 were identified as potential high dielectrics favorable for modern device applications. Our research has opened an avenue to explore novel high dielectric materials by combining crystal structure prediction and high throughput screening.
Pure single-mode Rayleigh-Taylor instability for arbitrary Atwood numbers
Authors: Liu Wanhai , Wang Xiang , Liu Xingxia , Yu Changping , Fang Ming , Ye Wenhua 
Published: March 2020

AbstractThe validity of theoretical investigation on Rayleigh-Taylor instability (RTI) with nonlinearity is quite important, especially for the simplest and the commonest case of a pure single-mode RTI, while its previous explicit solution in weakly nonlinear scheme is found to have several defections. In this paper, this RTI is strictly solved by the method of the potential functions up to the third order at the weakly nonlinear stage for arbitrary Atwood numbers. It is found that the potential solution includes terms of both the stimulating and inhibiting RTI, while the terms of the decreasing RTI are omitted in the classical solution of the weakly nonlinear scheme, resulting in a big difference between these two results. For the pure single-mode cosine perturbation, comparisons among the classical result, the present potential result and numerical simulations, in which the two dimensional Euler equations are used, are carefully performed. Our result is in a better agreement with the numerical simulations than the classical one before the saturation time. To avoid the tedious expressions and improve a larger valid range of the solution, the method of the Taylor expansion is employed and the velocities of the bubble and spike are, respectively, obtained. Comparisons between the improved and the simulation results show that the improved theory can better predict the evolution of the interface from the linear to weakly nonlinear, even to later of the nonlinear stages.
A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being
Authors: Michael D. R. , Jack A. A. , Masetti G. , Davies T. S. , Loxley K. E. , Kerry-Smith J. , Plummer J. F. , Marchesi J. R. , Mullish B. H. , McDonald J. A. K. , Hughes T. R. , Wang D. , Garaiova I. , Paduchová Z. , Muchová J. , Good M. A. , Plummer S. F. 
Published: March 2020

AbstractIn an exploratory, block-randomised, parallel, double-blind, single-centre, placebo-controlled superiority study (ISRCTN12562026, funded by Cultech Ltd), 220 Bulgarian participants (30 to 65 years old) with BMI 25–34.9 kg/m2 received Lab4P probiotic (50 billion/day) or a matched placebo for 6 months. Participants maintained their normal diet and lifestyle. Primary outcomes were changes in body weight, BMI, waist circumference (WC), waist-to-height ratio (WtHR), blood pressure and plasma lipids. Secondary outcomes were changes in plasma C-reactive protein (CRP), the diversity of the faecal microbiota, quality of life (QoL) assessments and the incidence of upper respiratory tract infection (URTI). Significant between group decreases in body weight (1.3 kg, p < 0.0001), BMI (0.045 kg/m2, p < 0.0001), WC (0.94 cm, p < 0.0001) and WtHR (0.006, p < 0.0001) were in favour of the probiotic. Stratification identified greater body weight reductions in overweight subjects (1.88%, p < 0.0001) and in females (1.62%, p = 0.0005). Greatest weight losses were among probiotic hypercholesterolaemic participants (−2.5%, p < 0.0001) alongside a significant between group reduction in small dense LDL-cholesterol (0.2 mmol/L, p = 0.0241). Improvements in QoL and the incidence rate ratio of URTI (0.60, p < 0.0001) were recorded for the probiotic group. No adverse events were recorded. Six months supplementation with Lab4P probiotic resulted in significant weight reduction and improved small dense low-density lipoprotein-cholesterol (sdLDL-C) profiles, QoL and URTI incidence outcomes in overweight/obese individuals.
Skeletal pathologies track body plan evolution in ichthyosaurs
Authors: Pardo-Pérez Judith M. , Kear Benjamin P. , Maxwell Erin E. 
Published: March 2020

AbstractChanging predator-prey interactions during the Mesozoic Marine Revolution (MMR) profoundly altered the trajectory of marine tetrapod evolution. Here, we assess potential signatures of this landmark transition through the fossil record of skeletal pathologies in ichthyosaurs — iconic marine reptiles that developed increasingly ‘fish-like’ body plans over time. We surveyed a stratigraphically constrained sample of 200 Middle Triassic ichthyosaur specimens and compared the type, distribution and prevalence of pathologies with an approximately equivalent assemblage of Early Jurassic age. Overall, skeletal pathologies were equally prevalent in these groups, and most often manifested in species >4 m long. However, pathological bones were found to be concentrated in the hind limbs and tail of Triassic ichthyosaurs, whereas the jaws, forelimbs, and ribcage were preferentially affected in Jurassic taxa. We posit that the occurrence of ankylosed zygapophyses in the caudal peak of Triassic ichthyosaurs could represent a functional by-product of their primitive ‘eel-like’ swimming. Conversely, increased instances of broken ribs in Jurassic ichthyosaurs may infer ramming or tail strike behaviours that characterise morphologically ‘fish-like’ marine tetrapods, such as modern toothed whales. Different categories of skeletal pathologies thus evidently reflect structural modifications in the ichthyosaur body plan, and indirectly coincide with ecological turnover during the MMR.
Generation and characterization of human induced pluripotent stem cells (iPSCs) from hand osteoarthritis patient-derived fibroblasts
Authors: Castro-Viñuelas R. , Sanjurjo-Rodríguez C. , Piñeiro-Ramil M. , Hermida-Gómez T. , Rodríguez-Fernández S. , Oreiro N. , de Toro J. , Fuentes I. , Blanco F. J. , Díaz-Prado S. 
Published: March 2020

AbstractKnowledge and research results about hand osteoarthritis (hOA) are limited due to the lack of samples and animal models of the disease. Here, we report the generation of two induced pluripotent stem cell (iPSC)-lines from patients with radiographic hOA. Furthermore, we wondered whether these iPSC-lines carried single nucleotide polymorphisms (SNPs) within genes that have been associated with hOA. Finally, we performed chondrogenic differentiation of the iPSCs in order to prove their usefulness as cellular models of the disease. We performed a non-integrative reprogramming of dermal fibroblasts obtained from two patients with radiographic rhizarthrosis and non-erosive hOA by introducing the transcriptional factors Oct4, Sox2, Klf4 and c-Myc using Sendai virus. After reprogramming, embryonic stem cell-like colonies emerged in culture, which fulfilled all the criteria to be considered iPSCs. Both iPSC-lines carried variants associated with hOA in the four studied genes and showed differences in their chondrogenic capacity when compared with a healthy control iPSC-line. To our knowledge this is the first time that the generation of iPSC-lines from patients with rhizarthrosis and non-erosive hOA is reported. The obtained iPSC-lines might enable us to model the disease in vitro, and to deeper study both the molecular and cellular mechanisms underlying hOA.
Development and Characterization of a Benchtop Corneal Puncture Injury Model
Authors: Snider Eric J. , Cornell Lauren E. , Acevedo Jorge M. , Gross Brandon , Edsall Peter R. , Lund Brian J. , Zamora David O. 
Published: March 2020

AbstractDuring recent military operations, eye-related injuries have risen in frequency due to increased use of explosive weaponry which often result in corneal puncture injuries. These have one of the poorest visual outcomes for wounded soldiers, often resulting in blindness due to the large variations in injury shape, size, and severity. As a result, improved therapeutics are needed which can stabilize the injury site and promote wound healing. Unfortunately, current corneal puncture injury models are not capable of producing irregularly shaped, large, high-speed injuries as seen on the battlefield, making relevant therapeutic development challenging. Here, we present a benchtop corneal puncture injury model for use with enucleated eyes that utilizes a high-speed solenoid device suitable for creating military-relevant injuries. We first established system baselines and ocular performance metrics, standardizing the different aspects of the benchtop model to ensure consistent results and properly account for tissue variability. The benchtop model was evaluated with corneal puncture injury objects up to 4.2 mm in diameter which generated intraocular pressure levels exceeding 1500 mmHg. Overall, the created benchtop model provides an initial platform for better characterizing corneal puncture injuries as seen in a military relevant clinical setting and a realistic approach for assessing potential therapeutics.