bluuebunny/crossref_metadata_2025_split huggingface dataset:
A single‐arm, non‐randomized investigation into the short‐term effects and follow‐up of a 4‐week lower limb exercise programme on kinesiophobia in individuals with knee osteoarthritis
Authors: Molyneux Jimmy , Herrrington Lee , Riley Ben , Jones Richard 
Published: January 2020

AbstractObjectiveTo investigate the short‐term effects and follow‐up of a 4‐week lower limb exercise programme on kinesiophobia in individuals with knee osteoarthritis (OA).DesignParticipants diagnosed with knee OA clinically against the American College of Rheumatology criteria were recruited. Participants completed a 4‐week lower limb exercise programme. Each participant completed two questionnaires, the Tampa Scale of Kinesiophobia and the Knee Injury and OA Outcome Score. Each measurement was completed at the baseline assessment, at Session 4 of the programme, at Session 8 of the programme, and 6 weeks after the exercise programme. Perceived levels of exertion rate of perceived exertion were measured after each exercise session using the modified Borg scale.ResultsFifty‐four participants took part in the study. Kinesiophobia decreased from the baseline assessment to 6 weeks after the exercise programme. KOOS pain, symptoms, sports and recreation, quality of life and activities of daily living score increased, therefore showed improvement. Correlational analysis highlighted a moderate negative correlation between the KOOS pain and kinesiophobia at baseline and 6 weeks after the exercise programme (0.44 and 0.48 respectively).ConclusionsUnderstanding baseline kinesiophobia scores could provide an important resource for health professionals who manage individuals with knee OA to improve the quality of care due to the correlation with pain changes and may improve exercise‐related outcomes for a longer duration.Highlights
Kinesiophobia is prevalent in individuals diagnosed with knee osteoarthritis (OA).
Kinesiophobia decreased in 75% of individuals with knee OA after a 4‐week exercise programme.
Correlation between pain and kinesiophobia at baseline and 6 weeks after an exercise programme.
An understanding of an individual's kinesiophobia level before an exercise programme is important for future prognosis of changes in pain.
Clinical Trial NumberNCT02734342
Quantum‐chemical models of KOH(KOBut)/DMSO superbasic systems and mechanisms of base‐promoted acetylene reactions
Authors: Vitkovskaya Nadezhda M. , Orel Vladimir B. , Kobychev Vladimir B. , Bobkov Alexander S. , Absalyamov Damir Z. , Trofimov Boris A. 
Published: January 2020

AbstractThe mechanisms of fundamental base‐promoted acetylene reactions, namely, nucleophilic addition to the triple C ≡ C bond (vinylation) and nucleophilic addition of acetylenic carbanion to a carbonyl group (ethynylation), are addressed using three models of different complexity—pentasolvate, monosolvate, and anionic—which describe the catalytic superbasic systems MOH(OBut)/DMSO (suspensions of alkali hydroxides or tert‐butoxides in dimethyl sulfoxide). The above acetylene reactions and sequential transformations of reagents arranged by the superbasic center are modeled within the framework of the most complete pentasolvate model, in which the superbase is represented by the KOH·5DMSO (KOBut·5DMSO) complexes. We have developed approaches to the construction of simplified models (monosolvate and anionic) to describe transformations in complex systems. The mechanisms of cascade assemblies of 6,8‐dioxabicyclo[3.2.1]octanes, cyclopentenones, and furan cycles from ketones and acetylenes in the superbasic environment are investigated using a uniform B2PLYP/6‐311+G**//B3LYP/6‐31+G* approach, and the energy profiles of these different carbo‐ and heterocycles are analyzed.
Robust feedback stabilization using high‐gain observer via event triggering
Authors: Behera Abhisek K. , Shim Hyungbo 
Published: January 2020

SummaryIn this article, the problem of robust output feedback stabilization of single‐input single‐output nonlinear systems is studied in the event‐triggering framework. In this work, an event‐triggered output feedback law based on a high‐gain observer is constructed, which guarantees the stability of closed‐loop system. First, the high‐gain observer with a triggering scheme is designed to estimate the plant state in the presence of external disturbances subject to any satisfactory accuracy of the estimation error. The observer‐based triggering mechanism decides the transmission of plant output to the observer by observing a certain event condition. Similarly, another triggering mechanism is designed using the estimated state of observer that triggers the control signal to be updated only when it is satisfied. Under this proposed event‐triggering framework, the stability of closed‐loop system is then analyzed. Here, we provide the simplified design technique, in which the high‐gain parameter and the triggering thresholds can be selected independently to achieve any desired bound for the plant trajectory. The results are finally demonstrated through simulation of a numerical example.
Event‐triggered cascade high‐gain observer and its application
Authors: Liu Wei , Huang Jie 
Published: January 2020

SummaryIn this article, we consider the event‐triggered cascade high‐gain observer (ETCHGO) for a class of nonlinear systems. By cascading lower dimensional observers, we design a cascade high‐gain observer together with a Zeno‐free event‐triggered mechanism to estimate the state of the plant. We show that the ETCHGO has the same steady‐state performance as the continuous‐time cascade high‐gain observer, that is, there is a finite time after which the estimation error will not exceed the given threshold, and moreover, the finite time and the threshold can be made sufficiently small by adjusting some design parameters. We also investigate an ETCHGO with saturation, which will reduce the peaking value while maintaining the steady‐state estimation performance. Furthermore, we use the ETCHGO with saturation to solve the output feedback stabilization problem for a class of nonlinear systems. An example is given to illustrate our results.
Copeptin and mid‐regional pro‐atrial natriuretic peptide in women with suspected or confirmed pre‐eclampsia: comparison with sFlt‐1/PlGF ratio
Authors: Neuman R. I. , van der Meer M. M. Alblas , Saleh L. , van den Berg S. A. A. , van den Meiracker A. H. , Danser A. H. J. , Visser W. 
Published: January 2020

ABSTRACTObjectivesArginine vasopressin (AVP) and atrial natriuretic peptide (ANP) may contribute to the pathogenesis of pre‐eclampsia (PE), but their role remains to be elucidated. Our aims were to evaluate the surrogates of AVP and ANP, C‐terminal pro‐AVP (copeptin) and mid‐regional pro‐ANP (MR‐proANP), as biomarkers for the prediction of PE‐related pregnancy complications and whether they are associated with angiogenic markers and/or clinical manifestations of PE.MethodsThis was a retrospective analysis of a prospective cohort study that enrolled pregnant women with suspected or confirmed PE, between December 2013 and April 2016. From each patient, a blood sample was obtained at study entry and serum levels of copeptin, MR‐proANP, soluble fms‐like tyrosine kinase‐1 (sFlt‐1) and placental growth factor (PlGF) were measured. We evaluated the ability of sFlt‐1, PlGF, sFlt‐1/PlGF ratio, copeptin and MR‐proANP, assessed either alone or combined with traditional predictors (gestational age, parity, diastolic blood pressure and proteinuria), to predict maternal complications and fetal/neonatal complications. Models were compared using concordance statistic (C‐index).ResultsA total of 526 women were evaluated in the study. Women with confirmed PE displayed elevated serum copeptin and MR‐proANP levels in comparison to those with suspected PE but no hypertensive disease of pregnancy. When combined with traditional predictors, the sFlt‐1/PlGF ratio displayed a higher C‐index than copeptin and MR‐proANP (0.76, 0.63 and 0.67, respectively, vs 0.60 for the traditional predictors alone) for the prediction of maternal complications. Similarly, for the prediction of fetal/neonatal complications, the sFlt‐1/PlGF ratio displayed a higher C‐index than copeptin and MR‐proANP when added to the traditional model (0.83, 0.79 and 0.80, respectively, vs 0.79 for the traditional predictors alone). When subdividing women according to sFlt‐1/PlGF ratio (≥ 85 vs < 85), no differences in copeptin levels were observed, while MR‐proANP level was elevated in women with sFlt‐1/PlGF ratio ≥ 85. Multiple regression analysis revealed that copeptin and MR‐proANP were independent determinants of proteinuria.ConclusionsCopeptin and MR‐proANP have limited value in predicting PE‐related complications when compared with the sFlt‐1/PlGF ratio. However, both copeptin and MR‐proANP were associated with proteinuria, with copeptin exerting this effect independently of the sFlt‐1/PlGF ratio. Copyright © 2020 ISUOG. Published by John Wiley & Sons Ltd.
Transperineal ultrasound assessment of maternal pelvic floor at term and fetal head engagement
Authors: Youssef A. , Brunelli E. , Montaguti E. , Di Donna G. , Dodaro M. G. , Bianchini L. , Pilu G. 
Published: January 2020

ABSTRACTObjectivesTo evaluate the association between pelvic floor dimensions in nulliparous women at term and fetal head engagement, as assessed by transperineal ultrasound.MethodsThis was a prospective observational study of nulliparous women at term. Before the onset of labor, transperineal ultrasound was used to measure the anteroposterior diameter (APD) of the levator hiatus and the angle of progression (AoP) at rest, on maximum pelvic floor muscle contraction and on maximum Valsalva maneuver (before and after visual feedback). We assessed the correlation between pelvic floor static and dynamic dimensions (levator hiatal APD and levator ani muscle coactivation) and AoP, which is an objective index of fetal head engagement.ResultsIn total, 282 women were included in the analysis. Among these, 211 (74.8%) women had a vaginal delivery while 71 (25.2%) had a Cesarean delivery. AoP was narrower in the Cesarean‐delivery group at rest, on maximum pelvic floor muscle contraction and on maximum Valsalva, whereas no differences in levator hiatal APD were found between the two groups. We found a negative correlation between levator hiatal APD at rest, on maximum pelvic floor muscle contraction and on maximum Valsalva and the duration of the second stage of labor. There was a positive correlation between AoP and levator hiatal APD on maximum Valsalva maneuver after visual feedback (r = 0.15, P = 0.01). Women with levator ani muscle contraction on Valsalva maneuver (i.e. coactivation), both pre and post visual feedback, had a narrower AoP at rest and on maximum Valsalva. After visual feedback, women with levator ani muscle coactivation had a longer second stage of labor than did those without (80.8 ± 61.4 min vs 62.9 ± 43.4 min (P = 0.04)).ConclusionsSmaller pelvic floor dimensions and levator ani muscle coactivation are associated with higher fetal head station and with a longer second stage of labor in nulliparous women at term. Copyright © 2020 ISUOG. Published by John Wiley & Sons Ltd.
The Trichoderma viride F-00612 consortium tolerates 2-amino-3H-phenoxazin-3-one and degrades nitrated benzo[d]oxazol-2(3H)-one
Authors: Voloshchuk Nataliya , Schütz Vadim , Laschke Laura , Gryganskyi Andrii P. , Schulz Margot 
Published: January 2020

AbstractNumerous allelopathic plant secondary metabolites impact plant–microorganism interactions by injuring plant-associated beneficial bacteria and fungi. Fungi belonging to the genus Trichoderma positively influence crops, including benzoxazinone-containing maize. However, benzoxazinones and their downstream metabolites such as benzoxazolinone and phenoxazinones are often fungitoxic. Specimen Trichoderma viride F-00612 was found to be insensitive to 100-µM phenoxazinone and 500-µM benzoxazolinone. Screening of 46 additional specimens of ascomycetes revealed insensitivity to phenoxazinones among fungi that cause disease in benzoxazinone-producing cereal crops, whereas many other ascomycetes were highly sensitive. In contrast, most of the screened fungi were insensitive to benzoxazolinone. T. viride F-00612 was associated with bacteria and, thus, existed as a consortium. By contrast, Enterobacter species and Acinetobacter calcoaceticus were prominent in the original specimen, and Bacillus species predominated after antibiotic application. Prolonged cultivation of T. viride F-00612 in liquid medium and on Czapek agar in the presence of < 100 µM phenoxazinone and < 500 µM benzoxazolinone resulted in a massive loss of bacteria accompanied by impacted fungal growth in the presence of phenoxazinone. The original consortium was actively involved in implementing metabolic sequences for the degradation and detoxification of nitrated benzoxazolinone derivatives. The 2-aminophenol was rapidly converted into acetamidophenol, but benzoxazolinone, methoxylated benzoxazolinone, and picolinic acid remained unchanged. Excluding phenoxazinone, none of the tested compounds markedly impaired fungal growth in liquid culture. In conclusion, members of the T. viride F-00612 consortium may contribute to the ability to manage benzoxazinone downstream products and facilitate BOA-6-OH degradation via nitration.
Autologous monocyte-derived DC vaccination combined with cisplatin in stage III and IV melanoma patients: a prospective, randomized phase 2 trial
Authors: Boudewijns Steve , Bloemendal Martine , de Haas Nienke , Westdorp Harm , Bol Kalijn F. , Schreibelt Gerty , Aarntzen Erik H. J. G. , Lesterhuis W. Joost , Gorris Mark A. J. , Croockewit Alexandra , van der Woude Lieke L. , van Rossum Michelle M. , Welzen Marieke , de Goede Anna , Hato Stanleyson V. , van der Graaf Winette T. A. , Punt Cornelis J. A. , Koornstra Rutger H. T. , Gerritsen Winald R. , Figdor Carl G. , de Vries I. Jolanda M. 
Published: January 2020

AbstractBackgroundAutologous dendritic cell (DC) vaccines can induce tumor-specific T cells, but their effect can be counteracted by immunosuppressive mechanisms. Cisplatin has shown immunomodulatory effects in vivo which may enhance efficacy of DC vaccination.MethodsThis is a prospective, randomized, open-label phase 2 study (NCT02285413) including stage III and IV melanoma patients receiving 3 biweekly vaccinations of gp100 and tyrosinase mRNA-loaded monocyte-derived DCs with or without cisplatin. Primary objectives were to study immunogenicity and feasibility, and secondary objectives were to assess toxicity and survival.ResultsTwenty-two stage III and 32 stage IV melanoma patients were analyzed. Antigen-specific CD8+T cells were found in 44% versus 67% and functional T cell responses in 28% versus 19% of skin-test infiltrating lymphocytes in patients receiving DC vaccination with and without cisplatin, respectively. Four patients stopped cisplatin because of toxicity and continued DC monotherapy. No therapy-related grade 3 or 4 adverse events occurred due to DC monotherapy. During combination therapy, one therapy-related grade 3 adverse event, decompensated heart failure due to fluid overload, occurred. The clinical outcome parameters did not clearly suggest significant differences.ConclusionsCombination of DC vaccination and cisplatin in melanoma patients is feasible and safe, but does not seem to result in more tumor-specific T cell responses or improved clinical outcome, when compared to DC vaccination monotherapy.
Pain, fatigue and depression symptom cluster in survivors of prostate cancer
Authors: Baden Manisha , Lu Liya , Drummond Frances J. , Gavin Anna , Sharp Linda 
Published: January 2020

AbstractPurposePain, fatigue and depression are common sequelae of a cancer diagnosis. The extent to which these occur together in prostate cancer survivors is unknown. We (i) investigated prevalence of the pain-fatigue-depression symptom cluster and (ii) identified factors associated with experiencing the symptom cluster among prostate cancer survivors.MethodsMen in Ireland diagnosed with prostate cancer 2–18 years previously were identified from population-based cancer registries and sent postal questionnaires. Cancer-related pain and fatigue were measured using the EORTC QLQ-C30 and depression using the DASS-21. Cut-offs to define ‘caseness’ were pain ≥ 25, fatigue ≥ 39 and depression ≥ 10. Associations between survivor-related factors, clinical variables and specific prostate cancer physical symptoms and the symptom cluster were assessed using multivariate logistic regression.ResultsA total of 3348 men participated (response rate = 54%). Twenty-four percent had clinically significant pain, 19.7% had clinically significant fatigue, and 14.4% had depression; 7.3% had all three symptoms. In multivariate analysis, factors significantly associated with the symptom cluster were living in Northern Ireland, experiencing back pain at diagnosis and being affected by incontinence, loss of sexual desire, bowel problems, gynecomastia and hot flashes post-treatment. There was a strong association between the cluster and health-related quality of life.ConclusionsThe pain-fatigue-depression symptom cluster is present in 1 in 13 prostate cancer survivors. Physical after-effects of prostate cancer treatment are associated with this cluster. More attention should be paid to identifying and supporting survivors who experience multiple symptoms; this may help health-related quality of life improve among the growing population of prostate cancer survivors.
Acidithiobacillus ferrianus sp. nov.: an ancestral extremely acidophilic and facultatively anaerobic chemolithoautotroph
Authors: Norris Paul R. , Falagán Carmen , Moya-Beltrán Ana , Castro Matías , Quatrini Raquel , Johnson D. Barrie 
Published: January 2020

AbstractStrain MG, isolated from an acidic pond sediment on the island of Milos (Greece), is proposed as a novel species of ferrous iron- and sulfur-oxidizing Acidithiobacillus. Currently, four of the eight validated species of this genus oxidize ferrous iron, and strain MG shares many key characteristics with these four, including the capacities for catalyzing the oxidative dissolution of pyrite and for anaerobic growth via ferric iron respiration. Strain MG also grows aerobically on hydrogen and anaerobically on hydrogen coupled to ferric iron reduction. While the 16S rRNA genes of the iron-oxidizing Acidi-thiobacillus species (and strain MG) are located in a distinct phylogenetic clade and are closely related (98–99% 16S rRNA gene identity), genomic relatedness indexes (ANI/dDDH) revealed strong genomic divergence between strain MG and all sequenced type strains of the taxon, and placed MG as the first cultured representative of an ancestral phylotype of iron oxidizing acidithiobacilli. Strain MG is proposed as a novel species, Acidithiobacillus ferrianus sp. nov. The type strain is MGT (= DSM 107098T = JCM 33084T). Similar strains have been found as isolates or indicated by cloned 16S rRNA genes from several mineral sulfide mine sites.
Dotinurad versus benzbromarone in Japanese hyperuricemic patient with or without gout: a randomized, double-blind, parallel-group, phase 3 study
Authors: Hosoya Tatsuo , Sano Takafumi , Sasaki Tomomitsu , Fushimi Masahiko , Ohashi Tetsuo 
Published: January 2020

Abstract
Background
Dotinurad is a novel selective urate reabsorption inhibitor that reduces serum urate levels in hyperuricemic patients with or without gout by selectively inhibiting urate transporter 1. This study was conducted to compare the efficacy and safety of dotinurad with those of benzbromarone.

Methods
In this 14-week, randomized, multicenter, double-blind, parallel-group, dose escalation, benzbromarone-controlled, phase 3 study, hyperuricemic patients with or without gout were randomized to two groups that received either dotinurad 2 mg or benzbromarone 50 mg. Dotinurad or benzbromarone was administered once a day for 14 weeks. The primary endpoint was the percent change in serum uric acid level from the baseline to the final visit.

Results
A total of 201 Japanese hyperuricemic patients with or without gout (dotinurad: 102, benzbromarone: 99) received at least one dose of the study drug. The mean percent change in serum uric acid level from the baseline to the final visit in the dotinurad and benzbromarone groups was 45.9% and 43.8%, respectively. Non-inferiority of dotinurad 2 mg to benzbromarone 50 mg in lowering serum uric acid was verified by the predefined non-inferiority margin (95% CI − 1.27 to 5.37%). The incidence of adverse events and adverse drug reactions was comparable between the two groups.

Conclusion
Dotinurad 2 mg was verified to have a non-inferior serum uric acid lowering effect compared with benzbromarone 50 mg, in Japanese hyperuricemic patients with or without gout.

ClinicalTrials.gov Identifier
NCT03100318.
Antezedenzien und Wirkmechanismen arbeitsbezogener erweiterter Erreichbarkeit – Wenn die Arbeitszeit nicht ausreicht
Authors: Thörel Eberhard , Pauls Nina , Göritz Anja S. 
Published: January 2020

ZusammenfassungDieser Beitrag der Zeitschrift Gruppe. Interaktion. Organisation. (GIO) beschäftigt sich mit Antezedenzien von arbeitsbezogener erweiterter Erreichbarkeit und der Rolle des Zeitaufwandes für Erreichbarkeit. Erreichbarkeit für Arbeitsbelange im Privatleben hat negative Folgen für das Wohlbefinden. Während mögliche Auswirkungen relativ gut untersucht sind, trifft dies auf Wirkmechanismen und Antezedenzien nicht zu. Bei 150 Bankangestellten untersuchten wir daher die Rolle des Zeitaufwands für Erreichbarkeit sowie mögliche Ursachen von Erreichbarkeit. Wir gingen davon aus, dass der Zeitaufwand für Erreichbarkeit Konflikte zwischen Arbeit und Privatleben sowie das Abschalten von der Arbeit vorhersagt, und dass diese Zusammenhänge durch eine Erhöhung der Gesamtarbeitszeit vermittelt werden. Ferner nahmen wir an, dass der Zeitaufwand mit Antezedenzien auf der individuellen und der arbeitsbezogenen Ebene zusammenhängt. Regressionsanalysen zeigen, dass der Zeitaufwand für Erreichbarkeit Konflikte zwischen Arbeit und Privatleben, nicht jedoch das Abschalten von der Arbeit vorhersagt. Die Gesamtarbeitszeit wirkt in beiden Fällen vermittelnd. Das Ausmaß von Erreichbarkeit (i. S. v. Zeitaufwand) wird auf der individuellen Ebene durch den (geringen) Wunsch nach einer Trennung von privaten und arbeitsbezogenen Lebensbereichen vorhergesagt (Segmentationspräferenz); auf der arbeitsbezogenen Ebene sind Beschäftigte je mehr erreichbar, desto stärker sie die das Gefühl haben, ihre Arbeit nicht in der verfügbaren Arbeitszeit erledigen zu können (Überlastung). Aus praktischer Sicht empfiehlt sich aus der Studie, den Zeitaufwand für Erreichbarkeit zu begrenzen: Auf individueller Ebene kann man Beschäftigte, die eine Integration der Lebensbereiche bevorzugen, auf mögliche Gefahren der Erreichbarkeit hinweisen und hinsichtlich der Arbeitsbedingungen an der Überlastung ansetzen.
GIAnT: A Group Interaction Annotation Tool to simplify psychological interaction analysis
Authors: Meyer Patrick , Thiele Lisa , Kauffeld Simone , Fingscheidt Tim 
Published: January 2020

AbstractIn this article of the journal Gruppe. Interaktion. Organisation. (GIO), we introduce the freely available tool , which was developed to accelerate the time-consuming annotation process of long group meetings. Although the systematic observation and analysis of interaction processes in group and dyadic contexts contributes to our understanding of how people actually behave in interactions, it is only rarely used in research and practice due to the immense amount of time involved in data preparation. To change this circumstance, provides a method for automated segmentation of the spoken utterances of all persons involved and displays them clearly in a temporal context. The tool is provided on Github (https://github.com/ifnspaml/GIAnT).