bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytogenetic mutation in a family with sickle-cell beta-thalassemia in North Sumatera, Medan, Indonesia: A preliminary study
Authors: Andani Christie Nur , Aman Adi Koesoema , Hariman Herman , Lubis Bidasari 
Published: April 2020

Background: The prevalence of Â Hb S/Î² Thalassemia has not been widely reported, and until now, there is a lack of statistical data on the prevalence of the disease in Indonesia. In 1974, cases of Î² thalassemia with Hb S were found in one family in Jakarta. The aim of this study was to describe the cytogenetic mutation in a family with Hb S/Î² thalassemia in North Sumatera.Methods: This was a descriptive study with a cross-sectional design conducted in one family of HbS patients with thalassemia trait, with a total of five samples. Complete blood count, hemoglobin electrophoresis examination, peripheral blood smear, PCR, and amplicon were performed to describe the hematology and cytogenetic profile of samples. Data were analyzed descriptively.Results : The father (64 years old) suffered from HbS (HbA = 58.3%, HbS = 38.3%, HbA2 = 2.8%) with heterozygote HbS mutation type. The mother (36 years old) suffered from Î²-thalassemia trait (HbA = 93.8, HbF = 1.2%, HbA2 = 5%) with Î²-thalassemia heterozygote IVS1-nt5 mutation type. The first child (male, 18 years old) suffered from HbS/Î² thalassemia (HbA = 25.9%, HbF = 22.4%, HbS = 48.2%, HbF = HbA2 = 3.5%), the second child was normal (HbA = 97.4%, HbA2 = 2.6%) and the third child (female, 10 years old ) suffered from HbS Î²-thalassemia (HbA = 3.3%, HbF = 25.5%, HbS = 67.6%, HbA2 = 3.6%). The first and third child had Î²-thalassemia with double heterozygote HbS and IVS1-nt5 mutation type.Conclusion: Population migration between nations followed by marriage could lead to cytogenetic mutations and cause sickle-cell beta-thalassemia. The finding of double heterozygous HbS mutation and beta thalassemia need to be explored further about the patientâ€™s fathers family.
The mucin 5AC level in medical faculty students with Computer Vision Syndrome (CVS)
Authors: Juliari I Gusti Ayu Made , Sari Dewi Ratna , Ratnasari Ni Luh Made Novi , Tri Handayani Ariesanti 
Published: April 2020

Introduction: Prolonged computer use will lead to a group of symptoms such as dryness of eyes, tired, headache and others called Computer Vision Syndrome (CVS). The decrease of Mucin 5 AC (MUC5AC) level could be one of the signs of dry eye disease on persons with CVS.Objective: The purpose of this study is to describe the Mucin 5AC level in medical faculty students of Udayana University, Bali, Indonesia with CVS.Method: It is an observational cross-sectional analytic study at Medical Faculty Udayana University on October 2018. Thirty four subject selected Â by purposive sampling and examined with Schirmer I test, Tear Break Up time (TBUT) test, and Mucin 5AC test. All of the subject then divided into CVS group and non-CVS group. Mucin 5AC level which less than 186.33 ng/mL categorized as low mucin, while more than 186.33 ng/mL categorized as normal mucin level. Data was analyzed by crosstabulation table and chi-square test with significant value p < 0.05.Result: Most of the students who diagnosed with CVS had lower mucin 5AC levels as much as 77,3% and 33,3% students with CVS had normal mucin 5AC level. Â This study analyses found there is significant association between level of mucin 5AC with CVS. The students with low level of mucin 5AC had 6,8 higher risk tend to be CVS (OR=6,8; CI 95%= 1,42-32,37; p=0,012).Conclusion: Low level of mucin 5AC has association with the risk of CVS in the medical students with prolonged computer use.
The relationship between Epidermal Growth Factor Receptor (EGFR) mutation and computed tomography findings in lung adenocarcinoma
Authors: Septiani Agnes , Dewi Pande Putu Ayu Patria , Widyoningroem Anita , Sensusiati Anggraini Dwi , Yamin Muhammad 
Published: April 2020

Background: Adenocarcinoma is the highest histology subtype of lung cancer. Epidermal Growth Factor Receptor (EGFR) is a factor that can predict the prognosis or response to treatment in patients with lung adenocarcinoma. Adenocarcinomas with EGFR mutations generally have a component of Ground Glass Opacity (GGO), smaller size, oval shape, multiple nodal metastases, and distant metastases. Â The aim of this study was to determine the relationship between EGFR mutations and CT scan images in pulmonary adenocarcinoma patients.Methods: This was a retrospective analytical study consisting of 92 samples, which were categorized into the mutation group (n = 62) and wild group (n = 30). This study was conducted at Dr. Soetomo General Hospital from January 2015 â€“ December 2017. The assessed CT-Scan findings were tumor size, shape, density, lymph node size, pleural effusion, and metastasis presence. The relationship was analyzed using the chi-square test and considered significant if the p-value was < 0.05.Results: This study found a significant relationship between EGFR mutations status with tumor size â‰¤ 3 cm (p = 0.02), lymph node size < 1.5 cm (p = < 0.001) and metastasis (p = 0.026). However, tumor density, tumor form, and pleural effusion did not have significant relationship with EGFR mutation.Conclusion: Tumor size â‰¤ 3 cm, lymph node size < 1.5 cm and presence of metastasis can be found in EGFR mutations pulmonary adenocarcinoma patients.
Electroencephalogram (EEG) features and clinical presentation in the elderly patient at neurologic policlinic Sanglah General Hospital between July 2015-2017 period
Authors: Meidiary Anak Agung Ayu , Gelgel Anna Marita , Putra I Gusti Ngurah Purna 
Published: April 2020

Background: Epilepsy has the highest prevalence and many diagnostic process challenges in the elderly population. Research about clinical, type of seizure, and electroencephalogram (EEG) features is very limited in Indonesia, including in Bali. This study aims to know clinical, type of seizure and electroencephalogram (EEG) features in elderly patients.Methods: Cross-sectional descriptive study was conducted among 76 elderly-patients consecutively at Neurologic Policlinic of Sanglah General Hospital Denpasar Bali between July 2015-2017. The clinical aspect, age, gender, and type of seizure were analyzed. Digital electroencephalogram (EEG) was obtained from all patients by 30 minutes of routine EEG recording. Data were analyzed using univariate analysis to determine the frequency distribution of each variable and showed as a percentage in SPSS version 17 for Windows.Results: There were 43 (56,57%) males and 33 (43,43%) females enrolled. Most of the epilepsy in elderly are symptomatic epilepsy which consists of post-stroke epilepsy (30,26%), post-traumatic epilepsy (1,32%), epilepsy-related to brain tumor (10,53%), and post encephalitis epilepsy (6,58%). The type of seizure dominated by partial seizure (57,9%) compared with others.Â EEG result of 76% of patients was classified as normal EEG, and 24% were abnormal EEG.Conclusion: Most of epilepsy in the elderly are symptomatic epilepsy, and the most cause is post-stroke epilepsy. The partial seizure is the most frequent type of seizure in the elderly.
Validity and Reliability of the Disaster Preparedness Knowledge Instrument for Health Cadres in Volcanic Disaster-Prone Areas
Authors: Kamaluddin Ridlwan , Trisnantoro Laksono , Alim Syahirul 
Published: April 2020

Background: Public health cadres can play an important role in improving disaster response and recovery. However, a multidimensional instrument is needed to assess the levels of disaster knowledge for community health cadres. This instrument is important to develop a complete and effective educational program for disaster preparation for health cadres. Therefore, this study aimed to test validity and reliability of the disaster preparedness knowledge instrument for health cadres in areas prone to volcanic disasters.Methods: A cross-sectional study was conducted by involving 300 respondents. The instrument was developed by conducting literature review followed by completing a qualitative study. We reduced the original instrument from 50 items to a final instrument comprising 41 items, classified into 6 categories: 1) early warning [16 items]; 2) disaster triage [4 items]; 3) basic life support [7 items]; 4) first aid [7 items]; 5) search and rescue [5 items]; and 6) logistic, communications and team organization [2 items].Â Instrument validation was assessed by using Pearson Product moment and the reliability was estimated by using internal consistency reliability.Results: 300 respondents were involved in this study with all respondents were women aged between 40-49 years old. All of them were either health cadre or high school students. In instrumental testing, all 41 items of the instrument were confirmed through content validity (Pearson Product Moment). Using internal consistency reliability, the study found reasonable inter-item reliability for all items (Cronbachâ€™s Î±: 0.785-0.807).Conclusion: Higher score on disaster triage aspect suggest that health cadres have pivotal role in emergency care during disaster. The finding revealed that disaster triage technique and skills for health cadres or lay man is very important.Â
Factors influencing smoking behavior and intensity of santri in Asrama Perguruan Islam (API) Islamic boarding school, Tegalrejo, Magelang, Central Java, Indonesia
Authors: Wijayanti Punik Mumpuni , Prabandari Yayi Suryo , Ismail Djauhar , Triratnawati Atik 
Published: April 2020

Introduction: Tabaco related death is estimated at 6 million people worldwide and it is portrayed to increase to 8 million in 2030. In ASEAN alone, there were approximately 121 million adult smokers in 2013, in which 50% of them were Indonesian. In Indonesia, it is illegal to sell cigarettes to people under 18 years old, but this regulation has weak field implementation and the number of under-age smokers is considerably high in Indonesia. Therefore, this study aimed to analyse the effects of knowledge and perception with smoking intention and behaviour among santris at Asrama Perguruan Islam (API) Islamic boarding school.Methods: A mix method study with sequential explanatory approach was conducted API Islamic boarding school in two phases namely qualitatively and quantitatively. 380 santris were enrolled in this study with interviewees for quantitative study was divided into three groups: santri who < 17 years old, santri who > 17 years old, and housekeepers.Results: The results showed that the knowledge significantly affected the smoking behaviour while had no influence toward smoking intention. On the other hand, no significant association was observed between perceptions with smoking intention while it significantly affected the smoking behaviour.Â Conclusion: It can be concluded that knowledge and perception were importance factors that influence smoking behaviour but had no effects toward smoking intention.
Concomitant injuries in maxillofacial fractures from head and neck division of surgery department at Dr. Sutomo General Hospital, Surabaya, Indonesia in 2015-2016 period
Authors: Wibowo Marjono Dwi 
Published: April 2020

Introduction:Â Maxillofacial fractures were caused most by traffic accidents. This study aims to know about concomitant trauma in maxillofacial fractures.Method: Observational descriptive study to evaluate maxillofacial fracture patients in Head and Neck Division of Surgery Department, Dr Sutomo Hospital between 2015 â€“ 2016.Result: Distribution of maxillofacial fracture patients in 2015 - 2016 based on sex, data on male patients was 77.52%. In 2015 male compared to female 70.5%, increased in 2016 male compared to female 83.82%. The side of fracture found midface fracture 48%, lower face 30.2% and combination mid and lower face 21.7%. Data on maxillofacial trauma with concomitant trauma were 46.5%. Concomitant injury in 2015 was 36.06% and in 2016 as many as 55.88% where there was an increase in cases of concomitant trauma. In 2015 there were 63.63% of the accompanying brain injuries, while in 2016 there were 42.1% brain injuries, where the trauma outside the brain injury also increased.Conclusion: Incidence of concomitant injuries in maxillofacial fractures is 46,5 %, and head injury found 50 % in concomitant injuries. The cause of traffic accidents were motorcycles.Â
Delayed nerve repair with epineural microsutures in traumatic radial nerve palsy: a case report
Authors: Yanti Ni Luh Putu Julita , Mahadewa Tjokorda Gde Bagus 
Published: April 2020

Introduction: Traumatic radial nerve palsy is a condition that need surgical management. Patients who neglect their symptoms or under diagnosed on examination, cause delays to their surgery treatment. Direct nerve repair with epineural microsutures is still the gold standart of surgical treatment for severe axonotmesis and neurotmesis injuries. In this article, we reported a case of nerve repair with epineural microsutures in traumatic radial nerve palsy.Case presentation: A 14-year-old male complained cramps, tingling, and numbness of his left arm and he was unable to extend his left wrist and fingers after he got a left arm injury 3 months ago. The electromyography (EMG) shown that left radial nerve lesion at left radial sulcus. Direct nerve repair is performed by epineural microsutures. Â Two weeks after surgery, we found improvement on the sensory process, but no improvement on the motoric process.Conclusion: Direct nerve repair with epineural microsutures is an effective treatment for radial nerve injury, but the timing for surgery influencing the result of operation.
Viral and non-viral causes in patients with hepatocellular carcinoma in Arifin Achmad General Hospital Riau Province during 2013-2017
Authors: Arfianti Arfianti , Putra Zulfatta Dwi , Delhaldita Ekral , Sembiring Ligat Pribadi , Asputra Hendra 
Published: April 2020

Background: Hepatocellular carcinoma (HCC) is the six most common cancer and the fourth leading cause of cancer-related death worldwide. Recent reports have suggested an increasing prevalence of HCC without evidence of hepatitis B and C infection (non-viral HCC).Methods: This was a descriptive study with cross-sectional approach that aimed to describe the distribution of viral and non-viral risk causes of hepatocellular carcinoma cases at Arifin Achmad General Hospital (AAGH), Riau Province in the period of 2013-2017. Data were obtained from medical records of HCC patients using total sampling method.Results: We included 129 cases of whom 64 (49,6%) were associated with viral causes and 65 (50,4%) wereÂ non-viral HCC. Bivariate analyses showed that there was no age difference between viral and non-viral HCC patients but the prevalence of non-viral HCC was significantly higher in females than males (odds ratio [OR], 3,12 ; 95% confidence interval [CI], 1,2-8,1; p=0,016). In addition, patients with alpha-fetoprotein (AFP) <400 ng/mL were more frequently associated with non-viral HCC compared with those with elevated AFP Â³400 ng/mL (OR, 3,71; 95%CI, 1,49-9,26; p=0,004).Conclusion: There was an equal distribution of viral and non-viral causes in HCC cases at AAGH, Riau Province during 2013-2017. This suggests changing etiologies of HCC that may impact HCC surveillance.
PKB XXVII Ilmu Penyakit Dalam: Comprehensive Management in Internal Medicine
Authors: Fakultas Kedokteran Universitas Udayana PKB XXVII Ilmu Penyakit Dalam 
Published: April 2020

ForewordInternal Medicine is quickly developing in all lines, from basic theories, pathophysiology, diagnostic procedures and therapy. The challenges of new cases and the re-emergence of re-emerging diseases in the era of globalization, modernization and industrialization require clinicians to constantly renew their knowledge and expertise and possess global standard quality to improve medical services. Information on medical science and technology is now easily accessible to anyone, produce an increasingly critical society and bring up challenges for clinicians.The advancement of Indonesian doctors must be supported by access to regional, national and international scientific communication in the form of scientific forums that present the latest research information and results, as well as a forum for discussion with experts in addition to establishing family bond for doctors.Pendidikan Kedokteran Berkelanjutan (PKB) Internal Medicine Department, Faculty of Medicine of Udayana University / Sanglah Hospital 2019 is a scientific activity in Internal Medicine topics held annually. In the series of activities of PKB XXVII in Internal Medicine Faculty of Medicine Universitas Udayana / Sanglah Hospital 2019, the update in the field of Internal Medicine will be presented in the form of training (workshops), symposiums, and expert discussions hence the opportunities for interaction between participants and experts are optimal. Development in the field of research is also a concern and we give appreciation in the form of opportunities to compete in oral papers and posters.Â Â Dr. I Wayan Losen Adnyana, SpPD-KHOM ChairmanÂ
The influence of maternal age and gestational age to urinary tract infection in Lempake Primary Health Care, East Kalimantan, Indonesia
Authors: Meiyanto Johanes Dwi 
Published: April 2020

Introduction: Urinary tract infection (UTI) is the second-largest of the worldâ€™s health burden just behind the respiratory tract infection. Pregnant women are at risk of suffering from urinary tract infection due to anatomical and physiological changes along the urinary tract. The study aims to find out the influence of maternal age and gestational age to UTI in Primary Health Care Center Lempake.Method: The research method was cross sectional with total sampling and using secondary data from the register book of emergency unit in Primary Health Care Center Lempake including all UTI cases in pregnancy from all pregnant patients undergone urinalysis from January 2017 until October 2018 (48 patients). It was then analyzed using logistic regression with STATA version 14.Result: Most of subjects distribution were maternal age group 26-35 years old (39.6%), third trimester of pregnancy (66.7%), and negative result of bacteriuria (81.3%). Maternal age group 26-35 years old was the the most one suffering from UTI/positive result of bacteriuria (55.6%) and had tendency 5.4 times to suffer from urinary tract infection (p=0.147; CI=0.56-51.71; OR=5.36) while gestational age in third trimester showed significant influence to urinary tract infection (p=0.05; CI=0.03-1.00; OR=0.18). The prevalence of urinary tract infection in this research was 18.7%.Â Conclusion: There were significant influences among maternal age and gestational age to UTI in Primary Health Care Center Lempake.
High incidence of varicocele among young men in Public Police Hospital Denpasar, Bali, Indonesia: a descriptive study
Authors: Parisudha Ryuu Damara , Suwedagatha I Gede 
Published: April 2020

Background: Varicocele is a progressive disease which possibly starts from puberty. When left untreated, it could progress and causes complications such as infertility. Determination on the representative national incidence and characteristic of varicocele has been a hard challenge due to the lack of data on varicocele epidemiological studies, especially in Bali. This study aims to know the characteristic of varicocele patients undergoing varicocelectomy in Bhayangkara Denpasar Hospital from January 2017 to December 2018.Â Methods: This research is a descriptive retrospective study with cross sectional approach. The population of the study consists of patients who were diagnosed with varicocele and underwent varicocelectomy in Bhayangkara Denpasar Hospital from January 2017 to December 2018. Total sampling method was used. Research data were retrieved by taking the patientâ€™s entire medical record with varicocele in Bhayangkara Denpasar Hospital from January 2017 to December 2018.Results: Ninty five samples were diagnosed with varicocele and underwent varicocelectomy. The highest percentage among age groups is 15 to 24 years (89.5%), with normal stature (94%), normal weight (86%), asymptomatic (90.5%), left unilateral varicocele (86.%), grade III varicocele (82,1%) and without comorbid (93.8%). The samples underwent varicocelectomy with Ivanissevich procedure (72.8%), operation time of â‰¤ 60 minutes (95.8%) and length of stay of â‰¤ 2 days (95.8%).Conclusion: The high incidence of varicocele in young adulthood is due to a majority of the samples being young police recruitment participants who were accidentally diagnosed during general medical check-up. Early screening on varicocele in the age group of 15 to 24 years is recommended to consider the need of sperm analysis examination and further deciding on the treatment options. One of the options is surgery.
The effect of native vitamin D therapy on echocardiographic parameters of patients with chronic obstructive pulmonary disease and early-stage chronic kidney disease
Authors: Bolotova E V , Trembach V V , Dudnikova A V 
Published: April 2020

Aim. To assess the dynamics of the main echocardiographic parameters in patients with chronic obstructive pulmonary disease (COPD) and early-stage chronic kidney disease (CKD) taking native vitamin D.Material and methods. The study included 264 patients, which were divided into two groups: experimental group (n=135) — patients with stage 2-4 COPD (men, mean age — 72,2±3,8 years, mean disease duration — 23,1±3,4 years); control group (n=136) — patients with stage 2-4 COPD, comparable in age and sex. Patients of both groups were divided into 4 subgroups depending on forced expiratory volume in 1 second and vitamin D levels. In the experimental group, native vitamin D therapy was performed according to regimen that maintains its level >34,3 ng/ml during the year; in the control group — according to the Russian Association of Endocrinologists guidelines. Echocardiography was performed for all patients at the beginning and end of the study.Results. In all subgroups of the experimental group, a statistically significant increase in the left ventricular ejection fraction was revealed (p<0,05); in patients with moderate COPD (GOLD 2) and vitamin D deficiency and patients with severe and very severe COPD (GOLD 3,4) and vitamin D insufficiency of the experimental group, we observed a significant decrease in the end-systolic dimension, average left atrial size and increase in stroke volume and stroke volume index, as well as normalization of the left ventricular geometry (p<0,05). In the control group after 12 months, no significant changes were detected.Conclusion. Maintaining of vitamin D level >34,3 ng/ml for 12 months in patients with COPD and early-stage CKD was associated with a significant improvement in myocardial remodeling. This indicates an improvement in cardiovascular adaptation and function.