bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perspectives from South African dietitians on infant and young child feeding regulations
Authors: Clarke Megan , Koen Nelene , du Plessis Lisanne 
Published: May 2020

AbstractObjective:This study aimed to determine the knowledge, perceptions and practices of dietitians in South Africa regarding the Regulations Relating to Foodstuffs for Infants and Young Children (R991).Design:A mixed methods, cross-sectional design was used.Setting:Quantitative data were collected using an online survey (n 282) and qualitative data by means of two focus group discussions (n 12).Participants:Participants were dietitians registered with the Health Professions Council of South Africa.Results:Dietitians’ average knowledge score was 64·8 % ± 12·5. Those working in infant and young child feeding had a 5 % higher knowledge score (95 % CI 1·4, 8·6, P = 0·01). Perceptions towards the Regulations were generally positive, and the majority of practices were compliant. Positive perceptions seemed to correlate with compliant practices. The most frequently selected enabler to the implementation of the Regulations was ‘Increase in other initiatives which support, protect and promote breastfeeding’, and the most frequently selected barrier was ‘Lack of awareness of the Regulation among health care providers’. The major themes from the focus group discussions comprised: less knowledge among dietitians and mothers about products controlled under the Regulations, non-compliance of other health care providers, the dietitians’ role in support and enforcement, the discrepancy between practice in private and public sectors and a lack of enforcement.Conclusions:South Africa has taken a bold step in legislating the International Code of Marketing of Breast-milk Substitutes and should upscale programmes to ensure consistent monitoring and enforcing of the Regulations.
At-will chromatic dispersion by prescribing light trajectories with cascaded metasurfaces
Authors: McClung Andrew , Mansouree Mahdad , Arbabi Amir 
Published: May 2020

AbstractChromatic dispersion spatially separates white light into colours, producing rainbows and similar effects. Detrimental to imaging but essential to spectroscopy, chromatic dispersion is the result of material properties in refractive optics and is considered an inherent characteristic of diffractive devices such as gratings and flat lenses. Here, we present a fundamental relation connecting an optical system’s dispersion to the trajectories light takes through it and show that arbitrary control over dispersion may be achieved by prescribing specific trajectories, even in diffractive systems. Using cascaded metasurfaces (2D arrays of sub-micron scatterers) to direct light along predetermined trajectories, we present an achromatic twisted metalens and experimentally demonstrate beam deflectors with arbitrary dispersion. This new insight and design approach usher in a new class of optical systems with wide-ranging applications.
hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma
Authors: Herviou Pauline , Le Bras Morgane , Dumas Leïla , Hieblot Corinne , Gilhodes Julia , Cioci Gianluca , Hugnot Jean-Philippe , Ameadan Alfred , Guillonneau François , Dassi Erik , Cammas Anne , Millevoi Stefania 
Published: May 2020

AbstractRNA G-quadruplexes (RG4s) are four-stranded structures known to control mRNA translation of cancer relevant genes. RG4 formation is pervasive in vitro but not in cellulo, indicating the existence of poorly characterized molecular machinery that remodels RG4s and maintains them unfolded. Here, we performed a quantitative proteomic screen to identify cytosolic proteins that interact with a canonical RG4 in its folded and unfolded conformation. Our results identified hnRNP H/F as important components of the cytoplasmic machinery modulating the structural integrity of RG4s, revealed their function in RG4-mediated translation and uncovered the underlying molecular mechanism impacting the cellular stress response linked to the outcome of glioblastoma.
Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids
Authors: Lõhmussaar Kadi , Kopper Oded , Korving Jeroen , Begthel Harry , Vreuls Celien P. H. , van Es Johan H. , Clevers Hans 
Published: May 2020

AbstractHigh-grade serous ovarian cancer (HG-SOC)—often referred to as a “silent killer”—is the most lethal gynecological malignancy. The fallopian tube (murine oviduct) and ovarian surface epithelium (OSE) are considered the main candidate tissues of origin of this cancer. However, the relative contribution of each tissue to HG-SOC is not yet clear. Here, we establish organoid-based tumor progression models of HG-SOC from murine oviductal and OSE tissues. We use CRISPR-Cas9 genome editing to introduce mutations into genes commonly found mutated in HG-SOC, such as Trp53, Brca1, Nf1 and Pten. Our results support the dual origin hypothesis of HG-SOC, as we demonstrate that both epithelia can give rise to ovarian tumors with high-grade pathology. However, the mutated oviductal organoids expand much faster in vitro and more readily form malignant tumors upon transplantation. Furthermore, in vitro drug testing reveals distinct lineage-dependent sensitivities to the common drugs used to treat HG-SOC in patients.
Collisional formation of top-shaped asteroids and implications for the origins of Ryugu and Bennu
Authors: Michel P. , Ballouz R.-L. , Barnouin O. S. , Jutzi M. , Walsh K. J. , May B. H. , Manzoni C. , Richardson D. C. , Schwartz S. R. , Sugita S. , Watanabe S. , Miyamoto H. , Hirabayashi M. , Bottke W. F. , Connolly H. C. , Yoshikawa M. , Lauretta D. S. 
Published: May 2020

AbstractAsteroid shapes and hydration levels can serve as tracers of their history and origin. For instance, the asteroids (162173) Ryugu and (101955) Bennu have an oblate spheroidal shape with a pronounced equator, but contain different surface hydration levels. Here we show, through numerical simulations of large asteroid disruptions, that oblate spheroids, some of which have a pronounced equator defining a spinning top shape, can form directly through gravitational reaccumulation. We further show that rubble piles formed in a single disruption can have similar porosities but variable degrees of hydration. The direct formation of top shapes from single disruption alone can explain the relatively old crater-retention ages of the equatorial features of Ryugu and Bennu. Two separate parent-body disruptions are not necessarily required to explain their different hydration levels.
Multicenter dataset of multi-shell diffusion MRI in healthy traveling adults with identical settings
Authors: Tong Qiqi , He Hongjian , Gong Ting , Li Chen , Liang Peipeng , Qian Tianyi , Sun Yi , Ding Qiuping , Li Kuncheng , Zhong Jianhui 
Published: May 2020

AbstractMulticenter diffusion magnetic resonance imaging (MRI) has drawn great attention recently due to the expanding need for large-scale brain imaging studies, whereas the variability in MRI scanners and data acquisition tends to confound reliable individual-based analysis of diffusion measures. In addition, a growing number of multi-shell diffusion models have been shown with the potential to generate various estimates of physio-pathological information, yet their reliability and reproducibility in multicenter studies remain to be assessed. In this article, we describe a multi-shell diffusion dataset collected from three traveling subjects with identical acquisition settings in ten imaging centers. Both the scanner type and imaging protocol for anatomical and diffusion imaging were well controlled. This dataset is expected to replenish individual reproducible studies via multicenter collaboration by providing an open resource for advanced and novel microstructural and tractography modelling and quantification.
Development of a metalloproteomic approach to analyse the response of Arabidopsis cells to uranium stress
Authors: Sarthou Manon C M , Revel Benoît H , Villiers Florent , Alban Claude , Bonnot Titouan , Gigarel Océane , Boisson Anne-Marie , Ravanel Stéphane , Bourguignon Jacques 
Published: May 2020

Abstract
Uranium is a naturally occurring radionuclide that is absorbed by plants and interferes with many aspects of their physiology and development. In this study, we used an ionomic, metalloproteomic, and biochemical approach to gain insights into the impact of uranyl ions on the proteome of Arabidopsis thaliana cells. First, we showed that most of the U was trapped in the cell wall and only a small amount of the radionuclide was found in the cell-soluble fraction. Also, the homeostasis of several essential elements was significantly modified in the cells challenged with U. Second, the soluble proteome from Arabidopsis cells was fractionated into 10 subproteomes using anion-exchange chromatography. Proteomic analyses identified 3676 proteins in the different subproteomes and the metal-binding proteins were profiled using inductively coupled plasma mass spectrometry. Uranium was detected in several chromatographic fractions, indicating for the first time that several pools of Arabidopsis proteins are capable of binding the uranyl ion in vivo. Third, we showed that the pattern of some lysine and arginine methylated proteins was modified following exposure to U. We further identified that the ribosomal protein RPS10C was dimethylated at two arginine residues in response to uranyl ion stress. Together, these results provide the first clues for the impact of U on the Arabidopsis proteome and pave the way for the future identification of U-binding proteins.
Adrenomedullin regulated by miRNA-574-3p protects premature infants with bronchopulmonary dysplasia
Authors: Gong Xiaohui , Qiu Jiajun , Qiu Gang , Cai Cheng 
Published: May 2020

Abstract
Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease (CLD) in premature infants. The present study was designed to elucidate the regulation of miRNA-547-3p on adrenomedullin (ADM) during the pathogenesis of BPD. We used Agilent Human 4x44K Gene Expression Microarrays v2 and miRCURY LNA™ microRNA Array to identify the differently expressed miRNA and its potential target genes, and certified them again by luciferase reporter gene analysis. We only retained target genes that met the following two conditions: first, coexisting in two databases, and second, expressing differences, and then identifying target genes by luciferase reporter gene analysis. Thus, we selected miRNA-574-3p and its target gene ADM for further research. We used real-time q-PCR to determine the expression of miRNA-574-3p and its target gene ADM in premature infants with BPD. We used microarray expression to analyze BPD samples and non-BPD samples and found that there were 516 differently expressed probes between them. The 516 differently expressed probes included 408 up-regulated probes and 108 down-regulated probes. The blood samples of BPD infants were detected by real-time q-PCR and found that the expression of miRNA-574-3p was decreased, while the expression of ADM was significantly increased. Luciferase reporter gene analysis showed that hsa-miR-574-3p can regulate the expression of luciferase with ADM 3′UTR, and decrease it by 61.84%. It has been reported in the literature that ADM can protect the premature infants with BPD. The target gene ADM of miRNA-574-3p may contribute to the prevention and treatment of BPD.
The serum angiotensin-converting enzyme 2 and angiotensin-(1-7) concentrations after optimal therapy for acute decompensated heart failure with reduced ejection fraction
Authors: Hisatake Shinji , Kiuchi Shunsuke , Kabuki Takayuki , Oka Takashi , Dobashi Shintaro , Fujii Takahiro , Ikeda Takanori 
Published: May 2020

Abstract
Objective: Elucidation of the role of angiotensin-converting enzyme (ACE) 2 (ACE2)/angiotensin (Ang)-(1-7)/Mas receptor axis in heart failure is necessary. No previous study has reported serial changes in ACE2 and Ang-(1-7) concentrations after optimal therapy (OT) in acute heart failure (AHF) patients. We aimed to investigate serial changes in serum ACE2 and Ang-(1-7) concentrations after OT in AHF patients with reduced ejection fraction (EF).
Methods: ACE2 and Ang-(1-7) concentrations were measured in 68 AHF patients with reduced EF immediately after admission and 1 and 3 months after OT. These parameters were compared with the healthy individuals at three time points.
Results: In the acute phase, Ang-(1-7) and ACE2 concentrations was statistically significantly lower and higher in AHF patients than the healthy individuals (2.40 ± 1.11 vs. 3.1 ± 1.1 ng/ml, P&lt;0.005 and 7.45 ± 3.13 vs. 4.84 ± 2.25 ng/ml, P&lt;0.005), respectively. At 1 month after OT, Ang-(1-7) concentration remained lower in AHF patients than the healthy individuals (2.37 ± 1.63 vs. 3.1 ± 1.1 ng/ml, P&lt;0.05); however, there was no statistically significant difference in ACE2 concentration between AHF patients and the healthy individuals. At 3 months after OT, there were no statistically significant differences in Ang-(1-7) and ACE2 concentrations between AHF patients and the healthy individuals.
Conclusion: ACE2 concentration was equivalent between AHF patients and the healthy individuals at 1 and 3 months after OT, and Ang-(1-7) concentration was equivalent at 3 months after OT.
Understanding the rotational variability of K2 targets
Authors: Krtička J. , Kawka A. , Mikulášek Z. , Fossati L. , Krtičková I. , Prvák M. , Janík J. , Skarka M. , Liptaj R. 
Published: May 2020

Context. Ultraprecise space photometry enables us to reveal light variability even in stars that were previously deemed constant. A large group of such stars show variations that may be rotationally modulated. This type of light variability is of special interest because it provides precise estimates of rotational rates.
Aims. We aim to understand the origin of the light variability of K2 targets that show signatures of rotational modulation.
Methods. We used phase-resolved medium-resolution X-shooter spectroscopy to understand the light variability of the stars KIC 250152017 and KIC 249660366, which are possibly rotationally modulated. We determined the atmospheric parameters at individual phases and tested the presence of the rotational modulation in the spectra.
Results. KIC 250152017 is a HgMn star, whose light variability is caused by the inhomogeneous surface distribution of manganese and iron. It is only the second HgMn star whose light variability is well understood. KIC 249660366 is a He-weak, high-velocity horizontal branch star with overabundances of silicon and argon. The light variability of this star is likely caused by a reflection effect in this post-common envelope binary.
La tour Eiffel : le premier laboratoire d’aérodynamique en France
Authors: Wesfreid José Eduardo 
Published: May 2020

Cet article décrit sommairement la recherche expérimentale de Gustave Eiffel, qui a mis en évidence la forte réduction de la trainée d’une sphère dans un écoulement à grande vitesse, accompagnant le changement occasionné par la transition de la couche limite du corps depuis l’état laminaire vers l’état turbulent (crise de trainée).
Cette découverte, mise en question initialement par Ludwig Prandtl, a été rendue possible par la conception et la réalisation par Eiffel d’un ensemble de nouvelles expériences astucieuses et de techniques innovantes créées autour de la tour Eiffel.
Un siècle après la découverte de cet effet, la compréhension de la dynamique de transition turbulente intermittente et bistable ainsi que la description des structures cohérentes instables présentes dans cette transition, restent ouvertes.
Generalized Vaidya solutions in bimetric gravity
Authors: Högås Marcus , Kocic Mikica , Torsello Francesco , Mörtsell Edvard 
Published: May 2020

Abstract
In general relativity, the endpoint of spherically symmetric gravitational collapse is a Schwarzschild–[(A)dS] black hole. In bimetric gravity, it has been speculated that a static end state must also be Schwarzschild–[(A)dS]. To this end, we present a set of exact solutions, including collapsing massless dust particles. For these, the speculation is confirmed.
Demonstration of the universality of molecular structures in prolate deformed nuclei
Authors: Canavan R , Freer M 
Published: May 2020

Abstract
The relationship between the deformed harmonic oscillator and the formation of molecular cluster structures, whereby valence neutrons are exchanged between cluster cores, is examined. It is found that there is a strong connection between the properties of the valence orbitals associated with deformed structures in the deformed harmonic oscillator and the molecular orbitals created by linear combinations of single-centre orbitals around nuclear clusters. The conclusion is that in addition to the appearance of clustering in the deformed harmonic oscillator that every prolate deformed cluster structure should have molecular orbitals built on that structure. This is demonstrated through a series of examples that range from 13C to 57Ni.
Thermodynamic-temperature data from 30 K to 200 K
Authors: Gaiser Christof , Fellmuth Bernd , Haft Norbert 
Published: May 2020

Abstract
New measurements of thermodynamic temperature T with Dielectric-Constant Gas Thermometry (DCGT) were performed at PTB from 50 K to 200 K. Particular care was taken to check for possible systematic sources of errors by performing experiments applying three working gases, namely helium, neon, and argon, the polarizability of which differs by a factor of up to eight. Together with former DCGT values of thermodynamic temperature the new results yield a consistent dataset in the range from 30 K to 200 K. This dataset is in good agreement with the newest results of Acoustic Gas Thermometry (AGT) and Refractive-Index Gas Thermometry (RIGT), which have quite different sources of uncertainty compared with DCGT. The combination of these DCGT, AGT, and RIGT data with the ‘Estimates of the differences between thermodynamic temperature and the ITS-90’, being as an appendix of the ‘Mise en pratique for the definition of the kelvin in the SI’ the present-day recommendation of the Consultative Committee for Thermometry, yields a new function T − T
90 versus ITS-90 temperature T
90 for the range from 35 K to 195 K, the uncertainty of which is reduced by a factor up to about four.
Algorithm for the formation of a linguistic integrated assessment of resource sustainability of an enterprise
Authors: Azarnova T V , Asnina N G , Bondarenko Yu V , Barkalov S A 
Published: May 2020

Abstract
The paper proposes an algorithm for the formation of a linguistic integrated assessment of the resource sustainability of an enterprise, based on the theory of extensive and intensive use of resources and methods of aggregating linguistic information using linguistic ordinal operators that formalize sequential averaging strategies for multicriteria estimation. The assessment of the extent of extensive and intensive use of resources in the work is carried out through groups of models that re ect the dependence of the resulting indicators of the enterprise on the quantity and quality of resources of various types. Quantitative indicators of the intensity of resource use are estimated by the method of chain substitutions; the Harrington function is used to switch to linguistic values. The integrated linguistic assessment obtained as a result of the work of the considered algorithm aggregates the linguistic values of the resource use intensity by all models and is interpreted as an integral indicator of resource stability, which is achieved due to intensive production factors.
Synthesis and scalarization of hierarchical vector criterion in production management problems
Authors: Sizikov A 
Published: May 2020

Abstract
The multicriteriality problem has many aspects. The paper is dedicated to one of them, namely: development of the methodology for building and using dynamically changing multi-level vector criteria for optimization of engineering and manufacturing complexes. The approach applied most frequently involves vector to scalar conversion of the optimization criterion. When multi-level criteria are used we have to deal with a system of embedded convolutions forming a hierarchical system of vectors. The current principles of making convolutions for such systems can be implemented in different ways depending on peculiarities of the controlled object and management goalsThis study discusses building of hierarchical criteria in mathematical setting up of engineering and manufacturing complex optimization problems. A method of forming and scalarization of a hierarchical vector criterion following a recurrent procedure based on an invariant representing a linear combination of Holder norms of partial criteria is suggested. An example of techniques usage in the development of software for multi-criterial optimization of refinery is given.
On the influence of linear blowing and constant temperature factor on the values of functionals of hypersonic aerodynamics
Authors: Bilchenko G G , Bilchenko N G 
Published: May 2020

Abstract
The problems of mathematical modeling of effective control of heat and mass transfer and friction on permeable cylindrical and spherical surfaces of hypersonic aircraft are considered. The systems of ordinary differential equations are obtained by A.A.Dorodnicyn generalized integral relations method to approximate the systems of partial differential equations describing laminar boundary layers on permeable cylindrical and spherical surfaces of hypersonic aircraft. The joint systems are applied in the mathematical model. The parameters of the mathematical model at the flow stagnation point are determined from the joint systems of nonlinear algebraic equations. The blowing into boundary layer, temperature factor and magnetic field are used as controls. Dependences of hypersonic aerodynamics functionals (the total heat flow, the total Newton friction force and total blowing system power) on controls (the linear blowing into boundary layer, the constant temperature factor, the constant magnetic field) are investigated. The domains of allowed values of functionals of hypersonic aerodynamics are obtained. The results of the computational experiments are presented: the dependences of total heat flow on controls; the dependences of total Newton friction force on controls; the dependences of blowing system power on controls; the mutual dependences of functionals (as the domains of allowed values “Heat and Friction”).
On the influence of linear temperature factor and constant blowing on the values of functionals of hypersonic aerodynamics
Authors: Bilchenko G G , Bilchenko N G 
Published: May 2020

Abstract
The problems of mathematical modeling of effective control of heat and mass transfer and friction on permeable cylindrical and spherical surfaces of hypersonic aircraft are considered. The systems of ordinary differential equations are obtained by A.A.Dorodnicyn generalized integral relations method to approximate the systems of partial differential equations describing laminar boundary layers on permeable cylindrical and spherical surfaces of hypersonic aircraft. The joint systems are applied in the mathematical model. The parameters of the mathematical model at the flow stagnation point are determined from the joint systems of nonlinear algebraic equations. The blowing into boundary layer, temperature factor and magnetic field are used as controls. Dependences of hypersonic aerodynamics functionals (the total heat flow, the total Newton friction force and total blowing system power) on controls (the constant blowing into boundary layer, the linear temperature factor, the constant magnetic field) are investigated. The domains of allowed values of functionals of hypersonic aerodynamics are obtained. The results of the computational experiments are presented: the dependences of total heat flow on controls; the dependences of total Newton friction force on controls; the dependences of blowing system power on controls; the mutual dependences of functionals (as the domains of allowed values “Heat and Friction”).