bluuebunny/crossref_metadata_2025_split huggingface dataset:
Separation of saccharides using fullerene-bonded silica monolithic columns via π interactions in liquid chromatography
Authors: Kobayashi Hiroshi , Okada Kazuya , Tokuda Shinnosuke , Kanao Eisuke , Masuda Yusuke , Naito Toyohiro , Takaya Hikaru , Yan Mingdi , Kubo Takuya , Otsuka Koji 
Published: August 2020

AbstractWe report on a potential method to separate sugars by using the specific interaction between fullerenes and saccharides in liquid chromatography (LC). Aromatic rings with high electron density are believed to interact strongly with saccharides due to CH–π and/or OH–π interactions. In this study, the fullerene-bonded columns were used to separate saccharides by LC under aqueous conditions. As a result, 2-aminobenzamide-labeled glucose homopolymer (Glcs) was effectively separated by both C60 and C70 columns in the range of Glc-1 to Glc-20 and high blood glucose level being retained in greater quantity. Furthermore, similar separations were identified by LC–mass spectrometry with non-labeled glucose homopolymers. Theoretical study based on molecular dynamics and DFT calculation demonstrated that a supramolecular complex of saccharide–fullerene was formed through CH–π and/or OH–π interactions, and that the interactions between saccharide and fullerene increase with the increase units of the saccharide. Additionally, the C60 column retained disaccharides containing maltose, trehalose, and sucrose. In this case, it was assumed that the retention rates were determined by the difference of the dipole moment in each saccharide. These results suggest that the dipole-induced dipole interaction was dominant, and that maltose—with the higher dipole moment—was more strongly retained compared to other disaccharides having lower dipole moment.
Genetic alterations in the 3q26.31-32 locus confer an aggressive prostate cancer phenotype
Authors: Simpson Benjamin S. , Camacho Niedzica , Luxton Hayley J. , Pye Hayley , Finn Ron , Heavey Susan , Pitt Jason , Moore Caroline M. , Whitaker Hayley C. 
Published: August 2020

AbstractLarge-scale genetic aberrations that underpin prostate cancer development and progression, such as copy-number alterations (CNAs), have been described but the consequences of specific changes in many identified loci is limited. Germline SNPs in the 3q26.31 locus are associated with aggressive prostate cancer, and is the location of NAALADL2, a gene overexpressed in aggressive disease. The closest gene to NAALADL2 is TBL1XR1, which is implicated in tumour development and progression. Using publicly-available cancer genomic data we report that NAALADL2 and TBL1XR1 gains/amplifications are more prevalent in aggressive sub-types of prostate cancer when compared to primary cohorts. In primary disease, gains/amplifications occurred in 15.99% (95% CI: 13.02–18.95) and 14.96% (95% CI: 12.08–17.84%) for NAALADL2 and TBL1XR1 respectively, increasing in frequency in higher Gleason grade and stage tumours. Gains/amplifications result in transcriptional changes and the development of a pro-proliferative and aggressive phenotype. These results support a pivotal role for copy-number gains in this genetic region.
An essential role of acetyl coenzyme A in the catalytic cycle of insect arylalkylamine N-acetyltransferase
Authors: Wu Chu-Ya , Hu I-Chen , Yang Yi-Chen , Ding Wei-Cheng , Lai Chih-Hsuan , Lee Yi-Zong , Liu Yi-Chung , Cheng Hui-Chun , Lyu Ping-Chiang 
Published: August 2020

AbstractAcetyl coenzyme A (Ac-CoA)-dependent N-acetylation is performed by arylalkylamine N-acetyltransferase (AANAT) and is important in many biofunctions. AANAT catalyzes N-acetylation through an ordered sequential mechanism in which cofactor (Ac-CoA) binds first, with substrate binding afterward. No ternary structure containing AANAT, cofactor, and substrate was determined, meaning the details of substrate binding and product release remain unclear. Here, two ternary complexes of dopamine N-acetyltransferase (Dat) before and after N-acetylation were solved at 1.28 Å and 1.36 Å resolution, respectively. Combined with the structures of Dat in apo form and Ac-CoA bound form, we addressed each stage in the catalytic cycle. Isothermal titration calorimetry (ITC), crystallography, and nuclear magnetic resonance spectroscopy (NMR) were utilized to analyze the product release. Our data revealed that Ac-CoA regulates the conformational properties of Dat to form the catalytic site and substrate binding pocket, while the release of products is facilitated by the binding of new Ac-CoA.
Structure of phospholipase Cε reveals an integrated RA1 domain and previously unidentified regulatory elements
Authors: Rugema Ngango Y. , Garland-Kuntz Elisabeth E. , Sieng Monita , Muralidharan Kaushik , Van Camp Michelle M. , O’Neill Hannah , Mbongo William , Selvia Arielle F. , Marti Andrea T. , Everly Amanda , McKenzie Emmanda , Lyon Angeline M. 
Published: August 2020

AbstractPhospholipase Cε (PLCε) generates lipid-derived second messengers at the plasma and perinuclear membranes in the cardiovascular system. It is activated in response to a wide variety of signals, such as those conveyed by Rap1A and Ras, through a mechanism that involves its C-terminal Ras association (RA) domains (RA1 and RA2). However, the complexity and size of PLCε has hindered its structural and functional analysis. Herein, we report the 2.7 Å crystal structure of the minimal fragment of PLCε that retains basal activity. This structure includes the RA1 domain, which forms extensive interactions with other core domains. A conserved amphipathic helix in the autoregulatory X–Y linker of PLCε is also revealed, which we show modulates activity in vitro and in cells. The studies provide the structural framework for the core of this critical cardiovascular enzyme that will allow for a better understanding of its regulation and roles in disease.
Deterministic control of an antiferromagnetic spin arrangement using ultrafast optical excitation
Authors: Windsor Y. W. , Ernst A. , Kummer K. , Kliemt K. , Schüßler-Langeheine Ch. , Pontius N. , Staub U. , Chulkov E. V. , Krellner C. , Vyalikh D. V. , Rettig L. 
Published: August 2020

AbstractA central prospect of antiferromagnetic spintronics is to exploit magnetic properties that are unavailable with ferromagnets. However, this poses the challenge of accessing such properties for readout and control. To this end, light-induced manipulation of the transient ground state, e.g. by changing the magnetic anisotropy potential, opens promising pathways towards ultrafast deterministic control of antiferromagnetism. Here, we use this approach to trigger a coherent rotation of the entire long-range antiferromagnetic spin arrangement about a crystalline axis in GdRh2Si2and demonstrate deterministic control of this rotation. Our observations can be explained by a laser-induced shift of the direction of the Gd spins’ local magnetic anisotropy, and allow for a quantitative description of the transient magnetic anisotropy potential.
Noble-metal-free nanocatalysts for hydrogen generation from boron- and nitrogen-based hydrides
Authors: Yao Qilu , Ding Yiyue , Lu Zhang-Hui 
Published: August 2020

We focus on the recent advances in non-noble metal catalyst design, synthesis and applications in dehydrogenation of chemical hydrides (e.g. NaBH4, NH3BH3, NH3, N2H4, N2H4BH3) due to their high hydrogen contents and CO-free H2production.
Studies on the correlation between mutation and integration of HBV in hepatocellular carcinoma
Authors: Cui Xiaofang , Wei Wei , Wang Chao , Qi Yanwei , Qin Xiao , Huang Lizhen , Li Weiyang 
Published: August 2020

Abstract
It is well known that both the mutation and integration of the Hepatitis B virus (HBV) are of great significance in liver cancer, however, the relationship between mutation and integration is still unclear. In the present study, sequencing data from 426 previously published samples were analyzed and 5374 specific HBV mutations in cancer tissues were discovered. By comparing integrated samples and non-integrated samples, we found that the integrated samples had higher sample single nucleotide variants (SNVs) positive rates and SNV numbers, as well as higher sample frequency of SNV in the X region of the HBV genome. Samples with HBV integration in the telomerase reverse transcriptase (TERT) region showed higher SNV positive rates and numbers than samples without integration. Moreover, the SNVs (209 [T&gt;G] and 531 [T&gt;C; T&gt;G]) were seen with higher frequency in samples with integration in the TERT region. Our study showed that the occurrence of viral integration events is closely related to the occurrence of SNV, and SNV in the X region should be more directly associated with viral integration. The present study provides an initial exploration of the relationship between HBV mutation and integration to help improve our understanding of the relationship between viral integration and mutation.
The origin of quasi-periodicities during circular ribbon flares
Authors: Kashapova L. K. , Kupriyanova E. G. , Xu Z. , Reid H. A. S. , Kolotkov D. Y. 
Published: August 2020

Context. Solar flares with a fan-spine magnetic topology are able to form circular ribbons. A previous study based on Hα line observations of the solar flares on 5 March 2014 revealed a uniform and continuous rotation of the magnetic fan-spine. A preliminary analysis of the flare time profiles revealed quasi-periodic pulsations (QPPs) with similar properties in hard X-rays, Hα, and microwaves.
Aims. In this work, we address the question of whether the observed periodicities are related to periodic acceleration of electrons or plasma heating.
Methods. We analysed QPPs in the Hα emission from the centre of the fan (inner ribbon R1), a circular ribbon (R2), a remote source (R3), and an elongated ribbon (R4) located between R2 and R3. We used methods of correlation, Fourier, wavelet, and empirical mode decomposition. We compared the QPPs in Hα emission with those in microwave and X-ray emission.
Results. We found multi-wavelength QPPs with periods around 150 s, 125 s, and 190 s. The 150 s period is seen to co-exist in Hα, hard X-rays, and microwave emissions, which allowed us to connect it with flare kernels R1 and R2. These kernels spatially coincide with the site of the primary flare energy release. The 125 s period is found in the Hα emission of the elongated ribbon R4 and the microwave emission at 5.7 GHz during the decay phase. The 190 s period is present in the emission during all flare phases in the Hα emission of both the remote source, R3, and the elongated ribbon, R4, in soft X-rays and in microwaves at 4–8 GHz.
Conclusions. We connected the dominant 150 s QPPs with the slipping reconnection mechanism occurring in the fan. We suggested that the period of 125 s in the elongated ribbon can be caused by a kink oscillation of the outer spine, connecting the primary reconnection site with the remote footpoint. The period of 190 s is associated with the three-minute sunspot oscillations.
Automatic catalog of RR Lyrae from ∼14 million VVV light curves: How far can we go with traditional machine-learning?
Authors: Cabral J. B. , Ramos F. , Gurovich S. , Granitto P. M. 
Published: August 2020

Context. The creation of a 3D map of the bulge using RR Lyrae (RRL) is one of the main goals of the VISTA Variables in the Via Lactea Survey (VVV) and VVV(X) surveys. The overwhelming number of sources undergoing analysis undoubtedly requires the use of automatic procedures. In this context, previous studies have introduced the use of machine learning (ML) methods for the task of variable star classification.
Aims. Our goal is to develop and test an entirely automatic ML-based procedure for the identification of RRLs in the VVV Survey. This automatic procedure is meant to be used to generate reliable catalogs integrated over several tiles in the survey.
Methods. Following the reconstruction of light curves, we extracted a set of period- and intensity-based features, which were already defined in previous works. Also, for the first time, we put a new subset of useful color features to use. We discuss in considerable detail all the appropriate steps needed to define our fully automatic pipeline, namely: the selection of quality measurements; sampling procedures; classifier setup, and model selection.
Results. As a result, we were able to construct an ensemble classifier with an average recall of 0.48 and average precision of 0.86 over 15 tiles. We also made all our processed datasets available and we published a catalog of candidate RRLs.
Conclusions. Perhaps most interestingly, from a classification perspective based on photometric broad-band data, our results indicate that color is an informative feature type of the RRL objective class that should always be considered in automatic classification methods via ML. We also argue that recall and precision in both tables and curves are high-quality metrics with regard to this highly imbalanced problem. Furthermore, we show for our VVV data-set that to have good estimates, it is important to use the original distribution more abundantly than reduced samples with an artificial balance. Finally, we show that the use of ensemble classifiers helps resolve the crucial model selection step and that most errors in the identification of RRLs are related to low-quality observations of some sources or to the increased difficulty in resolving the RRL-C type given the data.
Modeling the past and future activity of the Halleyid meteor showers
Authors: Egal A. , Wiegert P. , Brown P. G. , Campbell-Brown M. , Vida D. 
Published: August 2020

Context.We present a new numerical model of theη-Aquariid and Orionid meteor showers.Aims.The model investigates the origin, variability, and age of theη-Aquariid and Orionid apparitions from 1985 to the present day in order to forecast their activity over the next several decades.Methods.Through the numerical integration of millions of simulated meteoroids and a custom-made particle weighting scheme, we model the characteristics of everyη-Aquariid and Orionid apparition between 1985 and 2050. The modeled showers are calibrated using 35 yr of meteor observations, including the shower activity profiles and interannual variability.Results.Our model reproduces the general characteristics of the present-dayη-Aquariids and part of the Orionid activity. Simulations suggest that the age of theη-Aquariids somewhat exceeds 5000 yr, while a greater fraction of the Orionids is composed of older material. The 1:6 mean motion resonance with Jupiter plays a major role in generating some (but not all) Halleyid stream outbursts. We find consistent evidence for a periodicity of 11.8 yr in both the observations and modeled maximum meteor rates for the Orionids. Weaker evidence of a 10.7 yr period in the peak activity for theη-Aquariids needs to be investigated with future meteor observations. The extension of our model to future years predicts no significant Orionid outbursts through 2050 and four significantη-Aquariid outbursts, in 2023, 2024, 2045, and 2046.
Update Lebensstil – Was funktioniert in der Praxis?
Authors: Wienbergen Harm , Fach Andreas , Langer Harald , Hambrecht Rainer 
Published: August 2020

ZusammenfassungAktuelle Versorgungsstudien zeigen eine alarmierende Zunahme Lebensstil-assoziierter kardiovaskulärer Risikofaktoren, wie Adipositas und körperliche Inaktivität, in der Gesamtbevölkerung und bei Patienten mit Herz-Kreislauf-Erkrankungen. Um dem entgegenzuwirken, ist es wichtig, Patienten nach Koronarereignissen langfristig zu Verhaltensänderungen zu motivieren. Eine kürzlich publizierte Studie zeigte, dass ein intensives Präventionsprogramm (IPP) für 12 Monate, das primär von nicht ärztlichen Präventionsassistenten durchgeführt wurde und auf engmaschigen Kontakten zu den Patienten beruhte, die kardiovaskulären Risikofaktoren nachhaltig besser einstellen konnte. In der Gesamtbevölkerung ist eine Anleitung zu Lebensstilmodifikationen in verschiedenen Lebensphasen wichtig: beginnend im Kindes- und Jugendalter, über das Berufsleben, bis hin zum Rentenalter. Ein besonders hoher Bedarf besteht in Bevölkerungsschichten mit niedrigem sozioökonomischen Status. Durch präventive
Maßnahmen, wie Aufklärung zu mehr Bewegung, gesunder Ernährung und Nicht-Rauchen, kann hier ein großer Beitrag geleistet werden, die kardiovaskuläre Morbidität und Letalität zu senken.
Statement of the AGO and AG-CPC on the Aftercare/Follow-up for Surgical Procedures of the Lower Genital Tract after the Introduction of a New Cancer Screening Guideline
Authors: Hillemanns Peter , Tempfer Clemens , Beckmann Matthias W. , Küppers Volkmar , Quaas Jens 
Published: August 2020

AbstractThe new guideline on organized cancer screening programs has been in force in Germany since January 1st, 2020. The guideline has amended earlier recommendations on cytological examinations, which were previously carried out annually during screening. The guidelines-based recommendations on the appropriate follow-up for preinvasive and invasive lesions of the uterine cervix and endometrium are briefly outlined and differentiated from screening cytology and Pap/HPV co-testing as described in the guideline on organized cancer screening programs (oKFE-RL).
Extract of the Aerial Part of Polygala tenuifolia Attenuates d-Galactose/NaNO2-induced Learning and Memory Impairment in Mice
Authors: Zhang Dian , Wang Xiao , Li Rong , Wang Lin , Zhou Zihao , Fu Qi , Cao Yanjun , Fang Minfeng 
Published: August 2020

AbstractAlzheimerʼs disease, one of the most common types of age-related dementia, is characterized by memory deterioration and behavior disorder. The aboveground part of Polygala tenuifolia is a traditional Chinese medicine used for the treatment of amnesia. This study was conducted to investigate the ameliorating effect of the aerial part of P. tenuifolia on d-galactose/NaNO2-induced learning and memory impairment in mice. d-galactose (120 mg/kg) and NaNO2 (90 mg/kg) were injected intraperitoneally for 60 days to induce learning and memory impairment in mice. The aerial part of P. tenuifolia (25, 50, and 100 mg/kg) and piracetam (200 mg/kg) were simultaneously administered orally on days 15 – 60. Results of this study showed that aerial part of P. tenuifolia significantly decreased the latency time and increased the number of platform crossings in the Morris water maze compared with the Model group. Moreover,
the aerial part of P. tenuifolia significantly increased the latency time and decreased the error frequency in the step-down and step-through tests compared with the Model group. Meanwhile, the aerial part of P. tenuifolia was able to regulate the cholinergic system by increasing the levels of ACh and ChAT and decreasing the level of AChe. The aerial part of P. tenuifolia also significantly attenuated the levels of interleukin-1 beta and malonaldehyde and enhanced the interleukin-10 and glutathione levels and superoxide dismutase activity. Furthermore, treatment with aerial part of P. tenuifolia increased the protein and mRNA expression of brain-derived neurotrophic factor and tropomyosin receptor kinase B in the hippocampus. These results suggest that the aerial part of P. tenuifolia can ameliorate learning and memory impairments by modulating cholinergic activity, inhibiting neuroinflammation and oxidative stress, and regulating the
brain-derived neurotrophic factor and tropomyosin receptor kinase B signaling pathway.
Antegrade Double-J Stenting in Grossly Dilated and Tortuous Ureters
Authors: Shreshta Manish Kiran , Narkhede Amey , Gupta Arun 
Published: August 2020

AbstractFailure of retrograde approach for ureteric stenting warrants percutaneous nephrostomy with antergrade stenting to relieve the pressure symptoms and prevent the need for external drainage. However, in some tight ureteric strictures with grossly dilated tortuous ureter it may not be possible to navigate a ureteric stent across. In such instances pull through or rendezvous techniques have been advocated. Here, we have illustrated simple and novel techniques for traversing tortuous ureters with tight strictures. In one instance, a guide wire was snared via the perurethral approach and the system stabilized from both ends; the flexometallic sheath was then advanced into the urinary bladder across the stricture and a ureteric stent was deployed. In the other situation where the ureter was very tortuous, plain twisting and turning maneuver with retraction of whole assembly was done to straighten the ureter followed by advancement of the flexometallic sheath and stationing of the ureteric stent. In both the cases no significant procedure-related complications were seen and patients were discharged in stable condition. Our experience has led us to believe that occasionally all facilities may not be accessible immediately or the desired armamentarium may be unavailable for interventional radiologists, especially when the patient is on the table; in such cases, simple improvisation and techniques can come in handy to place a ureteric stent across a dilated tortuous ureter.
Transitional Cell Carcinoma and Pseudocirrhosis— A Case Report and Review of the Literature
Authors: Borisovsky Gilad , Goldstein Daniel A. , Eliakim-Raz Noa , Tamir Shlomit R. 
Published: August 2020

AbstractPseudocirrhosis is the occurrence of capsular retraction in patients with metastatic liver disease, usually of breast origin. It usually appears in these patients following chemotherapy and may result from shrinkage of the tumor, with scarring and nodular regeneration. In this article, we describe the first case of pseudocirrhosis, following treatment of transitional cell carcinoma metastatic to the liver. Portal vein thrombosis, a rare complication in pseudocirrhosis, was also detected in this patient.
Mirabegron Role in Urolithiasis Management: What you should Know
Authors: Rodríguez Eduar S. , Naranjo David 
Published: August 2020

AbstractThe purpose of the present study was to develop a narrative review of the available evidence of mirabegron efficacy in three scenarios: as a medical expulsive therapy; as a medical treatment to increase a successful access to stones before ureteroscopy, and management of double-J stent-related symptoms. Only two original studies have evaluated its use as a medical expulsive therapy, with contradictory results in terms of stone expulsion rate; however, both demonstrated a better pain control in the mirabegron group. One randomized controlled trial (RCT) found a higher successful access to ureteral stones when mirabegron was administered 1 week before the ureteroscopy. And two RCTs demonstrated its efficacy in diminishing discomfort related with double-J stent. There is a promising role for the use of mirabegron in the arsenal of urolithiasis treatment, even as a medical expulsive therapy, before ureteroscopy surgery, to increase the successful access to the stones and after the placement of ureteral catheter to reduce the related symptoms. However, larger-scaled prospective double-blinded RCTs are needed before it can be used with these purposes in the clinical scenario.
Redistributive Politics in Russia: The Political Economy of Agricultural Subsidies
Authors: Kvartiuk Vasyl , Herzfeld Thomas 
Published: August 2020

AbstractThis paper explores whether redistributive politics can explain differences in agricultural subsidies in Russia, a country whose autocratic regime represents a fertile ground for strategic redistribution. Relying on political economy literature, we examine the strategies regional and federal Russian politicians utilize to allocate and distribute agricultural subsidies. Using unique 2008–2015 panel data, we test whether politicians target loyal or easily swayed voters and whether they use large farms as vote brokers. We find federal and regional politicians to allocate more agricultural subsidies when political competition against the dominant party is higher. Moreover, they appear to also target large farms for voter mobilization.