bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pregnancy outcomes in women with inflammatory bowel disease: a 10‐year nationwide population‐based cohort study
Authors: Lee Han H. , Bae Jung Min , Lee Bo‐In , Lee Kang‐Moon , Wie Jeong H. , Kim Jin S. , Cho Young‐Seok , Jung Sung‐Ae , Kim Sang W. , Choi Hwang , Choi Myung‐Gyu 
Published: April 2020

SummaryBackgroundData relating to the association between inflammatory bowel disease (IBD) and pregnancy outcomes are lacking in Korea.AimsTo determine the incidence rates of pregnancy outcomes in women with IBD.MethodsA nationwide population study was performed using the Korean National Health Insurance claims database. A total of 2058 women with IBD consisting of ulcerative colitis (UC, n = 1469) and Crohn's disease (CD, n = 589) were pregnant between 2007 and 2016. We compared their incidence of pregnancy outcomes with 20 580 age‐matched controls without IBD. We also stratified the patients into those with quiescent to mild and moderate to severe IBD and compared the outcomes between them.ResultsThe pregnancy rate of women with IBD was lower than that of women without (25.7% vs 32.3%, P < 0.001). Caesarean section (46.5% vs 38.8%, odds ratio [OR] 1.43, 95% confidence interval [CI]: 1.17‐1.75), and intrauterine growth retardation (IUGR) (3.0% vs 1.0%, OR 2.89, 95% CI: 1.59‐5.26) were increased in CD patients than the controls. In regards to disease severity, there were no significant differences in pregnancy outcomes between patients with quiescent to mild IBD and the controls. However, the live birth rate of patients with moderate to severe IBD was lower than that of the controls (65.0% vs 69.9%, OR 0.79, 95%CI: 0.66‐0.94). In addition, moderate to severe IBD was significantly associated with spontaneous abortion (14.9% vs 11.9%, OR 1.33, 95% CI: 1.04‐1.68), caesarean section (46.4% vs 38.8%, OR 1.41, 95% CI: 1.14‐1.74) and IUGR (3.4% vs 1.0%, OR 3.20, 95% CI: 1.75‐5.84).ConclusionsWith the exception of moderate to severe disease, the incidences of adverse pregnancy outcomes in women with IBD are similar to that of the general population.
Impacts of CYP2C19 genetic polymorphisms on bioavailability and effect on platelet adhesion of vicagrel, a novel thienopyridine P2Y12 inhibitor
Authors: Zhang Yifan , Zhu Xiaoxue , Zhan Yan , Li Xiaojiao , Liu Cai , Zhu Yunting , Zhang Hong , Wei Haijing , Xia Yu , Sun Hongbin , Liu Yongqiang , Lai Xiaojuan , Gong Yanchun , Liu Xuefang , Li Yongguo , Ding Yanhua , Zhong Dafang 
Published: April 2020

AimsWe investigated the impacts of CYP2C19 polymorphisms on pharmacokinetics and pharmacodynamics of vicagrel in healthy Chinese subjects.MethodsCYP2C19 extensive metabolizers (EMs), intermediate metabolizers (IMs) and poor metabolizers (PMs; 16 subjects/group) participated in a randomized, open‐label, 2‐period cross‐over study. Each study period lasted 7 days, with a loading dose of 24 mg of vicagrel or 300 mg of clopidogrel on day 1, and maintenance doses of 6 mg of vicagrel or 75 mg of clopidogrel daily from day 2 to day 7. The pharmacokinetics and pharmacodynamics were assessed on day 1 and day 7.ResultsAfter a loading dose, the AUC0‐t of the active metabolite H4 by vicagrel was slightly lower in IMs and PMs (decreased by 21 and 27%, respectively) compared to EMs. Similar results were found after maintenance doses. In EMs, the AUC0‐t of H4 by vicagrel was somewhat higher than clopidogrel after the loading dose, and comparable with clopidogrel (90% confidence interval 0.94, 1.21) after the maintenance doses. However, it was much higher than clopidogrel in PMs, with a 1.28‐fold (loading dose) and a 73% (maintenance doses) increases compared to clopidogrel (P < 0.001). Consequently, the inhibition of platelet aggregation by vicagrel was greater than clopidogrel after both loading dose (28.2 vs 12.4% at 4 hours, P < 0.01) and maintenance doses (42.8 vs 24.6% at 4 hours, P < 0.001) in PMs.ConclusionsCYP2C19 polymorphisms have less impact on vicagrel as compared to clopidogrel. Drug exposure and response to vicagrel in PMs were even higher than to clopidogrel in IMs.
Bringing men in from the margins: Father‐inclusive practices for the delivery of parenting interventions
Authors: Pfitzner Naomi , Humphreys Cathy , Hegarty Kelsey 
Published: April 2020

AbstractAlthough there is a growing body of international work on barriers to engaging fathers in child and family services, there is limited research on factors that promote father engagement. In this article, we draw on case study data from the Australian Baby Makes 3 (BM3) programme to explore factors that promote father engagement in parenting support programmes. Our analysis shows single‐gender group work supported father engagement. BM3's father group work provided a safe space in the parenting support context where men could form intimate connections with other fathers and talk openly about their parenting experiences without fear of criticism from partners. These findings suggest that men often feel silenced and marginalized in the parenting sphere.
Intraluminal bypass devices as an alternative to protective ostomy for prevention of colorectal anastomotic leakage: a systematic review of the literature
Authors: De Hous N. , Lefevre J. H. , D’Urso A. , Van den Broeck S. , Komen N. 
Published: April 2020

AbstractAimAnastomotic leakage (AL) is the most important complication of colorectal surgery, leading to high morbidity and mortality. Protective ostomy, the current standard of care for protecting a colorectal anastomosis, has important drawbacks that require the creation of an alternative strategy. Over the past 30 years, several intraluminal bypass devices, designed to shield the anastomosis from the faecal stream, have been developed. The aim of this literature review was to create an updated overview of the devices available and their effectiveness in preventing AL, and to investigate whether they could serve as an alternative to protective ostomy in the future.MethodA systematic review of the literature on intraluminal bypass devices used for preventing colorectal AL was performed. The MEDLINE and Cochrane Library databases were searched, and articles were marked as relevant if an intraluminal bypass device was studied in an animal or human population.ResultsThe database search yielded 24 relevant articles related to 10 intraluminal bypass devices protecting a colorectal anastomosis. These articles included experimental animal studies, preclinical (pilot) studies, as well as retrospective and prospective clinical studies. Each device was assessed with regard to surgical technique, effectiveness and device‐related complications.ConclusionIntraluminal bypass devices show promise in preventing AL and its clinical consequences. However, there is insufficient high‐level evidence to draw firm conclusions. There is a need for randomized controlled trials that directly compare these devices with the protective ostomy.
Rivaroxaban Precision Dosing Strategy for Real‐World Atrial Fibrillation Patients
Authors: Konicki Robyn , Weiner Daniel , Herbert Patterson J. , Gonzalez Daniel , Kashuba Angela , Cao Yanguang Carter , Gehi Anil K. , Watkins Paul , Powell J. Robert 
Published: April 2020

Rivaroxaban is a direct‐acting oral anticoagulant approved to prevent strokes in patients with atrial fibrillation. Dosage recommendations are approved for all adult patients to receive either 15 mg or 20 mg once daily depending upon renal function. There are a number of reasons to believe rivaroxaban dosing could be more effective and/or safer for more patients if increased dosing precision is available. Because real‐world patients are more diverse than those studied in phase III clinical trials, we evaluated the extremes of creatinine clearance (CrCl) on rivaroxaban clearance using a published population pharmacokinetic model and applying exposure variation limits (±20%) based on published literature. The proposed dosing recommendations are 10 mg once daily (CrCl 15–29 ml/min), 15 mg once daily (CrCl 30–69 ml/min), 10 mg twice daily (CrCl 70–159 ml/min), and 15 mg twice daily (CrCl 160–250 ml/min). These new dosing recommendations should be prospectively tested for predictive accuracy and to assess the impact on AF patient efficacy and safety.
Increasing Student Accounting Self‐Efficacy, Interest, and Knowledge Using the DuPont Model
Authors: Eveleth Daniel M. , Baker‐Eveleth Lori J. , Stone Robert W. 
Published: April 2020

ABSTRACTThis research describes a DuPont Model activity used in an introduction to business course. An in‐class activity stimulated students’ confidence in their ability to apply the fundamental accounting principles building upon students’ knowledge of a lemonade stand. Accounting is often viewed by students in introductory courses as “a foreign language,” with common reactions by students of fear and anxiety about financial statements and financial ratios (Borja; Brazelton; Deer, Gohn, and Kanaya; Eber and Parker; and Goh and Scerri). The DuPont Model was developed to visually connect an income statement and the balance sheet to five common financial ratios. Using a preactivity and a postactivity questionnaire and 76 matched pairs of student responses, changes or differences in two student self‐efficacy measures were found. Over one‐half of these student pairs showed increases or improvements in these two self‐efficacy measures from preactivity to postactivity, implying that the DuPont Model positively influenced these self‐efficacy measures. Correlation analysis also showed meaningful, positive correlations among students’ self‐efficacy differences and their attitudes toward accounting. Furthermore, students’ perceived characteristics of the DuPont activity are significantly and positively correlated with students’ attitudes toward accounting. Finally, the results of the study are encouraging to the authors to continue using the DuPont Model activity.
Moral luck and moral performance
Authors: Lillehammer Hallvard 
Published: April 2020

AbstractThe aims of this paper are fourfold. The first aim is to characterize two distinct forms of circumstantial moral luck and illustrate how they are implicitly recognized in pre‐theoretical moral thought. The second aim is to identify a significant difference between the ways in which these two kinds of circumstantial luck are morally relevant. The third aim is to show how the acceptance of circumstantial moral luck relates to the acceptance of resultant moral luck. The fourth aim is to defuse a legitimate concern about accepting the existence of circumstantial moral luck, namely the fact that its existence implies substantial moral risks.
SOPHIE VON LA ROCHES ZEITSCHRIFT POMONA FÜR TEUTSCHLANDS TÖCHTER UND DER LITERARISCHE MARKT DER 1780ER JAHRE IM LICHTE UNVERÖFFENTLICHTER BRIEFE
Authors: Griffiths Elystan 
Published: April 2020

AbstractThis article presents an edition of letters by the readers of Sophie von La Roche's journal Pomona für Teutschlands Töchter (1783–4). In the introductory commentary, I examine the extent to which the letters provide evidence of women participating actively in the literary market as readers and writers and consider how far the correspondents were constrained by ideological discourses of the period. The article demonstrates how La Roche's interaction with readers shaped her self‐representation and her writing career beyond Pomona. It questions the view that La Roche's interactive relationship with her readers was a unique innovation by La Roche and demonstrates that its origins in fact lay in a competitor journal, the Magazin für Frauenzimmer, on which La Roche had previously collaborated. The article also examines the extent to which La Roche was responsible for giving her correspondents and readers the courage to publish. While some older correspondents showed considerable reluctance to appear in print, for other, younger writers La Roche served as a role model, while still others had little need of La Roche's encouragement and protection. Finally, the article shows that the scope and reach of the journal exceeded that of a literary women's group, and that La Roche relied on a network of supporters of both sexes.
ADAPTING SCHILLER'S DON KARLOS: VERDI, POSA, AND THE PROBLEM OF THE ‘FAMILIENGEMÄLDE’
Authors: Eastop Zak 
Published: April 2020

AbstractThis paper begins by re‐opening the discussion of the influence of Diderot's dramaturgical theory on Friedrich Schiller's Don Karlos. I consider Marquis von Posa's function as a structural device outside the play's narrative present, as much as his role as a character within the narrative. I argue that Schiller's move from the domestic to the political does not constitute an abandonment of Diderot's theory, but rather its reformulation, with Posa as the new, shared situation against which other characters reveal their conditions. Giuseppe Verdi and the librettists Joseph Méry and Camille du Locle were required to mirror Schiller's change in narrative focus, but by adding their ‘Fontainebleau’ and ‘Auto‐da‐Fé’ scenes, they foreshadow, and thus prepare for, the change, thereby avoiding the need to rely on the morally ambiguous Posa. Diderot's theory is reflected in the opera through Verdi's adherence to nineteenth‐century voice‐character norms, coupled with the use of real‐world character parallels, allowing those on stage to represent an état dans la société. The importance of Schiller's extra‐temporal Posa is emphasised by Verdi's writing ‘old‐fashioned’ melodic material for him, but having it played on the newly developed and futuristic cornet à pistons, a recent innovation in nineteenth‐century brass instrument manufacture, with which, musically, Posa is closely associated.
A MODERNIST MYSTIC: PHILOSOPHICAL ESSENCE AND POETIC METHOD IN GERDA WALTHER (1897–1977)*
Authors: Burns Niamh 
Published: April 2020

AbstractThis article presents the work of the neglected philosopher and mystic Gerda Walther (1897–1977) as a work of modernist philosophy. It offers an analysis of Walther's two most important texts, Ein Beitrag zur Ontologie der sozialen Gemeinschaften (1922) and Zur Phänomenologie der Mystik (1923), written during Walther's involvement in the Freiburg and Munich circles of early phenomenologists. Analysis of these texts reveals a compelling, non‐discursive philosophical methodology in which mystical essences unfold as social and historical realities, rather than some ideal standing behind or beyond materiality. Walther offers a pragmatic and poetic vision of language that is inadequate in a representational sense, yet still capable of guiding us to philosophical redemption. In quoting the poetry of Rainer Maria Rilke, she displays a complex interrelation between poetic and philosophical language in her work. This article argues for a significant re‐orientation of emerging scholarship on Walther, with a focus on her language and textual strategies. It positions her work in terms of recent developments in scholarship around the connections between phenomenology and modernist literature.
Genotypes and their interaction effects on reproduction and mating‐induced immune activation in Drosophila melanogaster
Authors: Fricke Claudia , Ávila‐Calero Sergio , Armitage Sophie A. O. 
Published: April 2020

AbstractMating causes considerable alterations in female physiology and behaviour, and immune gene expression, partly due to proteins transferred from males to females during copulation. The magnitude of these phenotypic changes could be driven by the genotypes of males and females, as well as their interaction. To test this, we carried out a series of genotype‐by‐genotype (G × G) experiments using Drosophila melanogaster populations from two distant geographical locations. We expected lines to have diverged in male reproductive traits and females to differ in their responses to these traits. We examined female physiological and behavioural post‐mating responses to male mating traits, that is behaviour and ejaculate composition, in the short to mid‐term (48 hr) following mating. We then explored whether a sexually transferred molecule, sex peptide (SP), is the mechanism behind our observed female post‐mating responses. Our results show that the genotypes of both sexes as well as the interaction between male and female genotypes affect mating and post‐mating reproductive traits. Immune gene expression of three candidate genes increased in response to mating and was genotype‐dependent but did not show a G × G signature. Males showed genotype‐dependent SP expression in the 7 days following eclosion, but female genotypes showed no differential sensitivity to the receipt of SP. The two genotypes demonstrated clear divergence in physiological traits in short‐ to mid‐term responses to mating, but the longer‐term consequences of these initial dynamics remain to be uncovered.
The relationship between environmental performance and environmental disclosure: A meta‐analysis
Authors: Doan My Hanh , Sassen Remmer 
Published: April 2020

AbstractThis research conceptually and empirically summarizes multiple aspects of the association between corporate environmental performance and corporate environmental reporting in previous literature, addressing the questions of (a) whether disclosure is a reliable indicator of performance and (b) whether variable measurement characteristics influence empirical outcomes. Systematic literature review and meta‐analytic techniques are employed to generate objective and valid summarized effects. The research covers a total of 251 effect sizes within 62 primary studies, representing a total of 56,387 observations. This study discovers a weak and negative association between environmental performance and environmental reporting, supporting the sociopolitical perspective that poor environmental performers have higher motivations to increase their level of disclosure than strong performers. At the same time, this research confirms the heterogeneity of previous studies in the field and verifies the effects of measurement methods on empirical outcomes.
Association between proteomics and obstructive sleep apnea phenotypes in a community‐based cohort of women
Authors: Ljunggren Mirjam , Theorell‐Haglöw Jenny , Freyhult Eva , Sahlin Carin , Franklin Karl A. , Malinovschi Andrei , Janson Christer , Lindberg Eva 
Published: April 2020

Summary
Proteomic‐based technologies offer new opportunities to identify proteins that might reflect the cardiometabolic stress caused by different aspects of sleep‐disordered breathing. We aimed to investigate whether severe obstructive sleep apnea and severe obstructive sleep apnea during rapid eye movement sleep are associated with changed levels of inflammatory and cardiac disease‐related proteins in a population‐based cohort of women. In the community‐based “Sleep and Health in Women” (SHE) cohort study, 400 women underwent polysomnography, anthropometric measurements and blood sampling. Two proteomic assays (Olink Proseek® Inflammation panel and Olink Proseek® Cardiovascular II panel), each measuring 92 proteins, were analysed in a subsample of 253 women. p‐Values were adjusted for multiple testing, with false discovery rate set at 10%. In unadjusted models, 57 proteins were associated with apnea−hypopnea index, 56 proteins with oxygen desaturation index and 64 proteins with rapid eye movement−apnea−hypopnea index. After adjustment for age, body mass index and plate, there were no significant associations between apnea−hypopnea index or oxygen desaturation index and any of the proteins. Severe obstructive sleep apnea during rapid eye movement sleep (rapid eye movement−apnea−hypopnea index ≥ 30) was associated with decreased levels of two anti‐inflammatory proteins; Sirt2 (q‐value .016) and LAP‐TGF‐β1 (q‐value .016). There was also a negative association between rapid eye movement−apnea−hypopnea index of ≥ 30 and Axin1 (q‐value .095), a protein thought to facilitate TGF‐β‐signalling. We conclude that severe obstructive sleep apnea during rapid eye movement sleep is associated with low levels of Sirt2, LAP‐TGF‐β1 and Axin1, anti‐inflammatory proteins involved in metabolic regulation and in the atherosclerotic process. For obstructive sleep apnea based on a whole night, the associations with cardiac and inflammatory proteins are weaker, and explained to a large extent by age and body mass index.
Competition × drought interactions change phenotypic plasticity and the direction of selection on Arabidopsis traits
Authors: Lorts Claire M. , Lasky Jesse R. 
Published: April 2020

Summary

Populations often exhibit genetic diversity in traits involved in responses to abiotic stressors, but what maintains this diversity is unclear. Arabidopsis thaliana exhibits high within‐population variation in drought response. One hypothesis is that competition, varying at small scales, promotes diversity in resource use strategies. However, little is known about natural variation in competition effects on Arabidopsis physiology.

We imposed drought and competition treatments on diverse genotypes. We measured resource economics traits, physiology, and fitness to characterize plasticity and selection in response to treatments.

Plastic responses to competition differed depending on moisture availability. We observed genotype–drought–competition interactions for relative fitness: competition had little effect on relative fitness under well‐watered conditions, whereas competition caused rank changes in fitness under drought. Early flowering was always selected. Higher δ13C was selected only in the harshest treatment (drought and competition). Competitive context significantly changed the direction of selection on aboveground biomass and inflorescence height in well‐watered environments.

Our results highlight how local biotic conditions modify abiotic selection, in some cases promoting diversity in abiotic stress response. The ability of populations to adapt to environmental change may thus depend on small‐scale biotic heterogeneity.