bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular response of the meniscus to injury: Effects of immobilization
Authors: Bray Robert C. , Smith Jacqueline A. , Eng Michael K. , Leonard Catherine A. , Sutherland Craig A. , Salo Paul T. 
Published: July 2002

AbstractFailed meniscal healing may lead to degenerative osteoarthritis of the knee. Healing is thought to be dependent upon an adequate blood supply, yet “normal” vascular changes during healing are not well understood. In this study we have quantified vasoactive and angiogenic responses to medial meniscal injury in a rabbit model under clinically relevant conditions, and related these to histological criteria of healing.Twenty‐six adult rabbits were given a standardized meniscal injury; 12 of these had the hind limb immobilized by pinning. Eight normal controls and 12 sham‐operated animals were also studied. After 4 weeks, animals underwent either vascular volume (vascular index) determination, or blood flow measurement using coloured microspheres. Histological analysis was also performed to assess meniscal healing.In injured animals, blood flow to the menisci was increased fivefold 4 weeks post‐operative this increase was prevented by immobilization. The vascular index of the menisci was also increased threefold by injury, but not significantly reduced by immobilization. Histological examination of injured menisci showed examples of healing and non‐healing tears in both mobile and immobile groups.Meniscal injuries are associated with characteristic changes in vascularity and perfusion, and these changes likely play a significant role in the healing process. Characterization of the vascular responses to meniscal injury may lead to techniques that can promote reliable healing of meniscal tears and thereby improve clinical outcomes. © 2001 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.
Chondrocyte apoptosis and regional differential expression of nitric oxide in the medial meniscus following partial meniscectomy
Authors: Kobayashi K. , Mishima H. , Hashimoto S. , Goomer R. S. , Harwood F. L. , Lotz M. , Moriya H. , Amiel D. 
Published: July 2002

AbstractPartial medial meniscectomy leads to tibial articular cartilage degeneration. Nitric oxide (NO) production increases with the development of osteoarthritis (OA) and has been shown to have a catabolic effect on chondrocytes. Since distribution of chondrocytic and fibroblastic cell types within the total cell population comprising meniscus is region‐specific, we compared NO production in the peripheral and central regions of the medial meniscus 12 weeks after partial medial meniscectomy and assessed chondrocyte apoptosis and NO production in the tibial articular cartilage. Additionally, transcriptional gene expression of inducible nitric oxide synthetase (iNOS) and immunohistochemical staining of nitrotyrosine were examined. The results showed that following partial medial meniscectomy, NO production in the central region of the medial meniscus and in the tibial articular cartilage were significantly higher than respective NO levels in normal and sham‐operated controls. Reverse transcription polymerase chain reaction (RT‐PCR) revealed a high transcriptional expression of the iNOS gene in the central region of the meniscus and in tibial articular cartilage following partial medial meniscectomy. Nitrotyrosine immunoreactivity was prominent in the central region of the medial meniscus and in the deep layer of the tibial articular cartilage and apoptotic cells were also detected in situ in the superficial zone of the tibial articular cartilage and central regions of the medial meniscus following partial medial meniscectomy. These observations suggest that the central region of the meniscus is responsible for NO synthesis associated with apoptosis in both meniscal and articular cartilage cells following partial meniscectomy. © 2001 Orthopaedic Research Society. Punlished by Elsevier Science Ltd. All rights reserved.
Early olfactory fiber projections and cell migration into the rat telencephalon
Authors: De Carlos Juan A. , López‐Mascaraque Laura , Valverde Facundo 
Published: July 2002

AbstractThe formation and development of primary olfactory axons was studied in the rat embryo using acetylcholinesterase histochemistry, immunocytochemistry for neuron‐specific β‐tubulin (TuJ1) and growth associated protein 43 (GAP43), and a fluorescent tracer DiI. Olfactory axons extend from the olfactory receptor neurons localized in the olfactory epithelium. These fibers grow to reach and enter the olfactory bulbs, where they form the first relay and integrative synaptic station in the olfactory system: the olfactory glomerulus. In this communication we address the development of primary olfactory fibers: first from the olfactory placode and later from the olfactory epithelium. Olfactory fibers enter the olfactory bulbs apparently in a disordered manner but soon arrange themselves in hook shaped aggregates of fibers, with many boutons (inmature synaptic terminals), to form the glomeruli. We detected this kind of structure for the first time at embryonic day 16. The olfactory receptor cells are usually anchored in the basal lamina of the olfactory epithelium but some of them, after reaching their targets, lose their epithelial attachment, leave the olfactory epithelium and migrate to and enter the olfactory bulbs. The traffic of cells between the olfactory epithelium and the brain lasts late into embryonic development. We describe four types of migratory mechanism used by different populations of cells to reach their targets in the telencephalic vesicle and propose the existence of migrating cells that enter the telencephalon. These data were corroborated by injections into the olfactory epithelium a of murine retrovirus carrying theEscherichia coli lac‐Z gene.
FGF‐9 is an autocrine/paracrine neurotrophic substance for spinal motoneurons
Authors: Kanda Takashi , Iwasaki Takayuki , Nakamura Satoshi , Ueki Akira , Kurokawa Tsutomu , Ikeda Kazuhiko , Mizusawa Hidehiro 
Published: July 2002

AbstractMotoneurons need muscle‐derived neurotrophic substances for their survival during the initial phase of their development, but after maturation they lose this requirement and can survive after axotomy. This suggests that some neurotrophic substances other than target‐derived ones control the survival of motoneurons in adults. Because spinal motoneurons express fibroblast growth factor‐9 (FGF‐9) messenger RNA, we hypothesized that FGF‐9 might be an autocrine or paracrine survival factor for motoneurons. FGF‐9 promoted the survival of motoneurons and upregulated the choline acetyltransferase (ChAT) activity in the dissociated cultures of ventral half of rat E13 spinal cord. Externally added FGF‐9 was more effective in low density cultures, and polyclonal blocking antibody against FGF‐9 significantly lowered the ChAT activity. Our results support an autocrine or paracrine role for FGF‐9 in mediating the survival of spinal motoneurons. Non‐target‐derived neurotrophic substances for motoneurons including FGF‐9 should be important in the pathogenesis of motor neuron disorders in the adults, especially amyotrophic lateral sclerosis.
Genetics of alcohol withdrawal
Authors: Schmidt L.G. , Sander T. 
Published: July 2002

SummaryAlcohol withdrawal is a clinically and etiologically heterogeneous syndrome caused by a complex interaction of environmental (e.g., amount of ethanol) and genetic factors. Multiple genes are considered to be involved in various components of the syndrome, each of them contributing only modestly to withdrawal vulnerability. Association studies using candidate genes of the dopamine, serotonin, gabaergic and opioidergic systems are reviewed and methodological limitations are discussed.
A blind spot for secondary gain affecting therapy outcomes
Authors: van Egmond J. , Kummeling I. 
Published: July 2002

SummaryBackgroundA study to determine whether the expectation for secondary gain held by psychiatric outpatients was associated with therapy outcomes.MethodsThe study was conducted at a Dutch psychiatric outpatient department. Our investigation set out to explore the expectation of obtaining secondary gain by directly asking the patient and clinician via questionnaires whether the patient anticipated to get specific ‘benefits’ from being in therapy.ResultsFrom 166 patients, 70 (42.2%) reported to expect secondary gain while in therapy. We found a significant relation between expectation for secondary gain and treatment outcomes. Patients with expectations for secondary gain were significantly more prone to poor therapy outcome. Only in nine of 147 cases (6%) did patients explicitly express their expectations for secondary gain towards a psychiatrist. Moreover, expectations for secondary gain did not appear to be related to Axis I and Axis II diagnoses.DiscussionSecondary gain appeared to be a ‘veiled motive’ for getting therapy: patients did not express their expectations for secondary gain explicitly towards a psychiatrist. This aspect of veiled motives is of particular relevance in regard to the fact that expectations for secondary gain appeared to affect therapy results.
Quality of life in older patients with systolic and diastolic heart failure
Authors: Jaarsma T. , Halfens R. , Abu‐Saad H. Huijer , Dracup K. , Stappers J. , van Ree J. 
Published: July 2002

AbstractAims:To get insight into the quality of life of a clinical practice sample of patients with heart failure that are admitted to the hospital. Secondly to determine differences between patients with systolic and diastolic dysfunction and finally to describe factors relating to quality of life.Methods:Three dimensions of quality of life (functional capabilities, symptoms and psychosocial adjustment to illness) were assessed during interviews of 186 patients with chronic heart failure. In addition, data on demographic, clinical and self‐care characteristics were collected and patients completed a 6‐min walk.Results:On average patients walked 172 m in 6 min and reported functioning in daily life at a mean level of 4.5 MET. Patients experienced four different symptoms of heart failure. Most of them described dyspnea, fatigue, sleep disturbance and ankle oedema. Problems with psychosocial adaptation occurred mostly in social and vocational domains. Overall well‐being of patients was rated as 6.4 on a 10‐point scale. In regard to quality of life, the only differences between patients with systolic and diastolic heart failure was the occurrence of ankle oedema and health‐care orientation. The variance in components of quality of life were partly explained by demographics and clinical characteristics. All three dimensions of quality of life were related to ability for self‐care.Conclusion:Patients with heart failure seen in clinical practice are often not comparable to patients described in major clinical trials or patients that are admitted for transplant evaluation. Their functional capabilities are more compromised, but they may have fewer problems with psychosocial adjustment. Patients with normal systolic dysfunction also report a low quality of life. It could be important to enhance self‐care abilities of patients to improve psychosocial adaptation to illness.
Inkjet‐Printed Conductive ITO Patterns for Transparent Security Systems
Authors: Gilshtein Evgeniia , Bolat Sami , Sevilla Galo Torres , Cabas‐Vidani Antonio , Clemens Frank , Graule Thomas , Tiwari Ayodhya N. , Romanyuk Yaroslav E. 
Published: July 2020

AbstractIndium tin oxide (ITO) is a transparent conducting material that is widely used in devices where high transparency of the electrodes is required, such as flat panel and liquid crystal displays, touch panels, smart windows, and many others. ITO layers are deposited on a large scale by magnetron sputtering and then structured by lithography to define desired patterns of transparent electrodes. Here, a method for direct printing of transparent conductive patterns from ITO nanoparticle ink is communicated. The method combines inkjet printing with fast flash lamp annealing whereby the main novelty is to use an additional layer of a colored organic dye onto printed ITO to increase light absorption. The dye coating is instantly heated together with the underlying ITO layer by a light pulse, leading to an instant rise of the surface temperature, which is translated into improved optoelectronic properties of the ITO layers. Inkjet‐printed ITO patterns processed with the dye‐assisted flash lamp annealing exhibit a transmittance of up to 88% at 550 nm and resistivity of 3.1 × 10−3 Ω cm. Transparent touch‐sensing trackpad and capacitive touch sensors are demonstrated based on the printed ITO patterns, which can be utilized in transparent security systems and other transparent Internet‐of‐Things devices.
Thermosensitive Exosome–Liposome Hybrid Nanoparticle‐Mediated Chemoimmunotherapy for Improved Treatment of Metastatic Peritoneal Cancer
Authors: Lv Qijun , Cheng Lili , Lu Yao , Zhang Xiaoge , Wang Yizhen , Deng Junfeng , Zhou Jiangbing , Liu Bo , Liu Jie 
Published: July 2020

AbstractMetastatic peritoneal carcinoma (mPC) is a deadly disease without effective treatment. To improve treatment of this disease, a recently developed hyperthermic intraperitoneal chemotherapy (HIPEC) has emerged as the standard of care. However, the efficacy of this approach is limited by inefficient drug penetration and rapidly developed drug resistance. Herein, a nanotechnology approach is reported that is designed to improve drug delivery to mPC and to augment the efficacy of HIPEC through delivery of chemoimmunotherapy. First, the drug delivery efficiency of HIPEC is determined and it is found that chemotherapy agents cannot be efficiently delivered to large tumors nodules. To overcome the delivery hurdle, genetically engineered exosomes‐thermosensitive liposomes hybrid NPs, or gETL NPs, are then synthesized, and it is demonstrated that the NPs after intravenous administration efficiently penetrates into mPC tumors and releases payloads at the hypothermia condition of HIPEC. Last, it is shown that, when granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) and docetaxel are co‐delivered, gETL NPs effectively inhibit tumor development and the efficacy is enhanced when HIPEC is co‐administered. The study provides a strategy to improve drug delivery to mPCs and offers a promising approach to improve treatment of the disease through combination of locoregional delivery of HIPEC and systemic delivery of chemoimmunotherapy via gETL NPs.
Defect Engineering in Manganese‐Based Oxides for Aqueous Rechargeable Zinc‐Ion Batteries: A Review
Authors: Xiong Ting , Zhang Yaoxin , Lee Wee Siang Vincent , Xue Junmin 
Published: July 2020

AbstractThe development of advanced cathode materials for aqueous the zinc ion battery (ZIB) represents a crucial step toward building future large‐scale green energy conversion and storage systems. Recently, significant progress has been achieved in the development of manganese‐based oxides for ZIB via defect engineering, whereby the intrinsic capacity and energy density have been enhanced. In this review, an overview of the recent progress in the defect engineering of manganese‐based oxides for aqueous ZIBs is summarized in the following order: 1) the structures and properties of the commonly used manganese‐based oxides, 2) the classification of the various types of defect engineering commonly reported, 3) the various strategies used to create defects in materials, and 4) the effects of the various types of defect engineering on the electrochemical performance of manganese‐based oxides. Finally, a perspective on the defect engineering of manganese‐based oxides is proposed to further enhance their electrochemical performance as a ZIB cathode.
Revisit, Reform, and Redesign: A Novel Dissection Approach for Demonstrating Anatomy of the Orbit for Continuing Professional Development Education
Authors: Cotofana Sebastian , Gavril Diana L. , Frank Konstantin , Schenck Thilo L. , Pawlina Wojciech , Lachman Nirusha 
Published: July 2020

Advanced postgraduate medical education for health‐care professionals is constantly evolving. Understanding facial anatomy and especially its vascular system is crucial when performing soft tissue filler injections to avoid adverse events including tissue loss or irreversible blindness. Standard anatomical resources often fall short of elucidating clinically relevant concepts in more highly specialized areas of interest. A novel dissection approach for demonstrating the anatomy of the lateral orbit was presented at scientific meetings to participants from dermatology, plastic surgery, and general practice. Results from the post‐course online survey (n = 52) were analyzed. The results of the survey reveal a high educational impact and a high clinical relevance of the novel dissection approach. In addition, the majority of respondents (97.7%; n = 51) felt that the exposed anatomical structure of the orbit and face improved their ability to safely perform cosmetic procedures on the face. More experienced respondents who had previously attended at least five cadaveric dissections were more likely to strongly agree that reviewing anatomy through this novel dissection approach increased their confidence in avoiding periorbital vascular danger zones. As minimally invasive outpatient procedures continue to evolve, practicing physicians and mid‐level providers often face the challenge of having to reconcile preexisting anatomical knowledge with new clinical practice. Skills required to navigate high impact anatomy include visualization of structures that form the navigational landscape and avoidance of key danger zones. The novel dissection approach to the lateral orbit reflects the increasing focus on revisiting, reforming, and redesigning anatomy for continuing professional development activities.
The management of sustainable development: A longitudinal analysis of the effects of environmental performance on economic performance
Authors: Bassetti Thomas , Blasi Silvia , Sedita Silvia Rita 
Published: July 2020

AbstractThe literature on sustainable development has largely focused on investigating the relationship between companies' environmental and economic performance. However, many aspects remain unexplored, and empirical studies are far from reaching a consensus due to the heterogeneity of the environmental and economic measures and methodologies used. This study contributes to the literature on sustainable development by considering a panel of 998 US companies observed over the period 2003–2017 using both traditional panel data methods and an unconditional quantile regression technique. The empirical evidence confirms that environmental performance, measured in terms of environmental orientation and environmental innovation, positively affects returns on assets and equity. It also demonstrates that these returns change across quantiles and depend on the capacity of green companies to generate the same streams of income as nongreen companies but with less capital. In other words, green firms tend to be more efficient in generating future wealth.
Mitral regurgitation due to a mediastinal desmoid tumor: A case report and review of the literature
Authors: Shebli Baraa , Alzahran Ayham , Mansour Ali , Kabaweh Sami , Agha Sarab , Shareef Bayan , Abdullah Manar 
Published: July 2020

AbstractMediastinal tumors may cause a wide range of symptoms; therefore, it should be considered in the differential diagnosis, after excluding common causes, when dealing with pulmonary and cardiac symptoms such as dyspnea or even mitral regurgitation. The most common site of the desmoid tumors is the abdomen, but in very rare cases, it can be located in the mediastinum.
A neural network‐based instrumental method for light fastness assessment with dataset validation
Authors: Karami Samaneh , Izadan Hossein , Zeinal Hamadani Ali 
Published: July 2020

AbstractA novel instrumental method for the light fastness assessment has been established. The accuracy of the visual method is affected by undesirable constraints, such as the different severity and the complications due to off‐tone color change of the specimens. Thus, it was desired to develop an instrumental method of the light fastness assessment. In this regard, a neural network‐based instrumental method of the light fastness assessment was developed. First, a proper light fastness panel was prepared, and then the visual light fastness assessments of experienced and inexperienced observers were collected. The accuracy and repeatability of the visual assessment results from these two groups of the observers were analyzed using different statistical criteria. The statistical analysis has shown that the mean of three trials of the inexperienced observers can be combined with the mean of the results obtained by experienced. Thus, all the results from the inexperienced and experienced observers were used to prepare a valid dataset for training a neural network. Different neural network structures trained with the prepared valid dataset. Among all of the implemented structures, the most accurate neural network structure is the one with one hidden layer and a 3‐7‐1 structure. The root mean square error and correlation coefficients of proposed 3‐7‐1 NN are 0.32 and 0.975, respectively, for the test sets. According to these results and the results from the comparison of the instrumental and visual assessment of the light fastness, it was concluded that the proposed neural network can be used for the instrumental light fastness assessment.
Characterization of wheat germplasm conserved in the Indian National Genebank and establishment of a composite core collection
Authors: Phogat B.S. , Kumar Sandeep , Kumari Jyoti , Kumar Naresh , Pandey Avinash Chandra , Singh T.P. , Kumar Sundeep , Tyagi R.K. , Jacob Sherry Rachel , Singh Amit Kumar , Srinivasan Kalyani , Jalli Radhamani , Bisht I.S. , Archak Sunil , Karale Moreshwar , Sharma Pankaj , Yadav Mamta , Joshi Uma , Mishra Priyanka , Kumari Geeta , Aftab Tariq , Gambhir Rajeev , Gangopadhyay K.K. , Rathi Y.S. , Pal Narendra , Sharma R.K. , Yadav S.K. , Bhatt K.C. , Singh Baleshwar , Prasad T.V. , Solanki Y.P.S. , Singh Dhiraj , Dutta M. , Yadav Mahesh C. , Rana J.C. , Bansal Kailash C. 
Published: July 2020

AbstractThe use of untapped plant genetic resources of wheat (Triticum spp.) can enhance its productivity. In the present study, we characterized 22,416 accessions of three different species of wheat conserved in the Indian National Genebank using 23 qualitative and 12 quantitative traits to develop a core set. These accessions were highly diverse on the basis of range, coefficient of variation, and Shannon–Weaver diversity index. Initial grouping was done on the bases of species and origin, and thereafter, agromorphological data were used to develop core sets for each species group using the heuristic approach with PowerCore. Finally, a composite core set was constituted comprising 2,226 accessions, which included 1,779 accessions of bread wheat (T. aestivum L.), 394 of durum wheat [T. turgidum L. subsp. durum (Desf.) van Slageren], and 53 of emmer wheat [T. dicoccon Schrank; syn. T. turgidum L. subsp. dicoccon (Schrank) Thell]. The core set was validated under field conditions. Also, the coincidence rate of range (CR) (bread wheat, 85.78%; durum wheat, 87.52%; and emmer wheat, 95.34%) and variable rate of the coefficient of variation (VR) (bread wheat, 174.9%; durum wheat, 136.5%; and emmer wheat, 105.81%) were more than the threshold values of 80 and 100%, respectively. The phenotypic correlations among different traits attributable to coadapted gene complexes and total variation shown by principal components in the entire set were also mostly preserved in the core set. The composite wheat core and the trait‐specific germplasm sets identified would serve as valuable resources for global wheat improvement programs.