bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synchronized optimization of the logistics system of a tobacco high-bay warehouse under production task fluctuations
Authors: Gao Jie , Xie Weidong , Shi Dingke , Wu Jian , Wang Rui 
Published: December 2024

Abstract
Cigarette companies often utilize a logistics system where high-bay warehouse areas for semi-finished and finished tobacco products are located close together and linked via trolley tracks. However, fluctuations in production tasks, such as adding new tasks, handling emergency orders, and canceling existing orders, can introduce challenges to production, including high storage capacity ratios and limited trolley transportation capacity. Therefore, this study proposes a synchronized optimization method for the logistics system in tobacco high-bay warehouses designed to improve storage and transportation efficiency. A synchronized storage allocation model is developed to balance the capacity ratios between the two high-bay warehouses to tackle high storage capacity ratios. The efficiency is improved by minimizing stacker handling time and optimizing shelf center of gravity, with the warehouses’ capacity ratios serving as key constraints. A neural network model is introduced to enhance trolley transportation capacity by predicting the optimal number of trolleys needed for each functional area based on task volume, boosting overall transportation efficiency. Experimental analysis demonstrates that the proposed coordinated operation method enhances high-bay warehouse storage efficiency by 36.82% and transportation efficiency by 8%. This study achieves synchronized optimization of the logistics system in cigarette enterprises by designing a shared coordination scheme for storage locations and trolleys. Lastly, this study effectively supports the tobacco industry in addressing dynamic production demands and provides valuable insights for practical engineering applications.
Machine learning-based compression of quantum many body physics: PCA and autoencoder representation of the vertex function
Authors: Zang Jiawei , Medvidović Matija , Kiese Dominik , Di Sante Domenico , Sengupta Anirvan M , Millis Andrew J 
Published: December 2024

Abstract
Theoretical approaches to quantum many-body physics require developing compact representations of the complexity of generic quantum states. This paper explores an interpretable data-driven approach utilizing principal component analysis (PCA) and autoencoder neural networks to compress the two-particle vertex, a key element in Feynman diagram approaches. We show that the linear PCA offers more physical insight and better out-of-distribution generalization than the nominally more expressive autoencoders. Even with ∼10–20 principal components, we find excellent reconstruction across the phase diagram suggesting the existence of heretofore unrealized structures in the diagrammatic theory. We show that the principal components needed to describe the ferromagnetic state are not contained in the low rank description of the Fermi liquid (FL) state, unlike those for antiferromagnetic and superconducting states, suggesting that the latter two states emerge from pre-existing fluctuations in the FL while ferromagnetism is driven by a different process.
France
Authors: Heirbaut Dirk 
Published: December 2024

Abstract
In France, codifying private law goes together with a strong executive and a weak legislature. After several failed efforts to produce a civil code during the French Revolution, a military dictator, Napoleon, promulgated the French Civil Code in 1804 to bring stability. It became so successful that many consider it to be the ideal model of codification and the true constitution of France, but Napoleon’s success stands in contrast to later events. Around 1900 and after World War II, France was unable to enact a new civil code, and currently, it does not get further than piecemeal revisions. In the shadow of the 1804 Civil Code stand its lesser siblings, the 1806 Code of Civil Procedure and the 1807 Commercial Code. The Commercial Code was a stepchild from the start. Napoleon mostly wanted it to punish bankrupt merchants, and later French lawmakers did nothing to protect the Commercial Code against erosion. Due to a lack of enthusiasm, a new code did not appear after World War II, and the 2000 French Commercial Code is only a consolidation. The 1806 Code of Civil Procedure came after disastrous experiments during the French Revolution. It was beneficial for French advocates, who, therefore, resisted reform. The 1958 Constitution of the Fifth Republic broke their power over civil procedure, resulting in the 1975 French Code of Civil Procedure with a more balanced view of civil procedure.
World War II
Authors: Parasidis Efthimios 
Published: December 2024

Abstract
This chapter details the extraordinary efforts dedicated to the military biomedical complex during World War II. A sprawling healthcare system supported American military personnel around the globe. The drive to weaponize atomic energy, chemicals, and biological agents situated the entire scientific enterprise in a high-stakes race for military superiority. Wartime needs inspired innovations in healthcare operations, medical treatment, and preventive health. The government also created a new, civilian-led military science agency with a robust agenda in medical research and weapons development. During the work, the ethical implications of research with human subjects received little attention. Many subjects were coerced into experiments or were unwitting participants. Others were told they would be prosecuted for espionage if they revealed the existence of the studies. Researchers themselves were subject to dangerous occupational hazards. Amid the most expansive war in the history of humankind, national security and wartime exigencies cast aside the legal and ethical concerns.
Justice at Nuremberg
Authors: Parasidis Efthimios 
Published: December 2024

Abstract
This chapter describes the horrific concentration camp experiments conducted by Nazi Germany during World War II and the moral debates surrounding those experiments as detailed by contemporary German scientists and officials. It reviews key legal and ethical arguments set forth by the prosecution and defense during the Nuremberg Doctors’ Trial and reveals that US witnesses provided false testimony during the trials regarding the scope of American research ethics protocols. The chapter also details how American researchers largely ignored the Nuremberg Code and how, for decades after WWII, the US research establishment proliferated without much attention to ethical practices and with little regard for the legal rights of vulnerable populations, many of whom were coerced into risky research or were unwitting research participants. Within this environment, the military was the first to adopt policies that created protections for research participants, but the policies were rarely implemented or enforced.
New Laws to Facilitate the Development and Administration of Medical Countermeasures
Authors: Parasidis Efthimios 
Published: December 2024

Abstract
This chapter describes the rising national security threats from the 1990s to the 9/11 attacks and beyond. It details how a part of the response to these threats was the creation of new laws and programs to facilitate the development and administration of medical countermeasures to combat chemical, biological, radiological, and nuclear (CBRN) agents. The chapter provides a comprehensive evaluation of the anthrax and smallpox immunization programs, both of which were controversial. It includes discussion of the political aspects of the programs, vaccine development challenges, and adverse events suffered by vaccine recipients. The chapter unravels the legal challenges to the programs and how the lawsuits led Congress to create new laws that—among their provisions—bypassed standard FDA protocols for safety and efficacy review and granted broad legal shields to government and industry for countermeasure-related injuries. It also explains how these new measures have increased the risk that individuals will be exposed to unsafe or ineffective medical products.
Might Topical Heparin Help With Occlusion Emergencies After Accidental Intra-Arterial Hyaluronic Acid Injections?
Authors: Stabile Marco , Cavallini Maurizio , Raichi Mauro 
Published: December 2024

Abstract

Hyaluronic acid fillers rarely cause potentially devastating occlusive adverse events that require immediate hyaluronidase salvage infiltrations. An exploratory photographic investigation probed whether topical heparin's anticlotting and anti-inflammatory properties could synergize with and enhance the effectiveness of hyaluronidase. Based on heparin pharmacodynamics, the authors explored the rationale for associating topical heparins with hyaluronidase in treating occlusive side effects following accidental intra-arterial hyaluronic acid injections. In the first case, an occlusion in the right superior labial artery area, highlighted by reddish-blue net-like skin discoloration (livedo reticularis), developed below the nasal pyramid shortly after 3 intradermal injections of low-viscosity hyaluronic acid gel, rapidly progressing to the glabellar and forehead regions. Within 1 h after the hyaluronidase salvage injection (80 IU), topical low-molecular-weight heparin (40 mg enoxaparin) was uniformly applied, and the procedure was repeated every 8 h for 15 days. In the second case, a cluster of severe occlusive lesions developed in the nose and nasal tip areas after 3 hyaluronic acid injections (formulation and doses as previously stated). After the first week, enoxaparin (4000 IU) was applied topically every 8 h for an additional 3 weeks. Two sequences of photographs document the occlusions’ evolution toward almost complete skin repair after 28 days (first case: immediate combined treatment) and 15 days (second case: sequential treatment spaced 1 week).
The anti-inflammatory and antithrombotic pharmacodynamics of heparin and heparin derivatives offer a promising rationale as an add-on option (combined hyaluronidase and topical heparin) to treat the occlusive side effects caused by hyaluronic acid.

Level of Evidence: 5 (Therapeutic)
Ecogeographical rules in the white-eared opossum: Didelphis albiventris has a geographically unstructured generalist phenotype along its distribution
Authors: Chemisquy M Amelia , Bustamante Erick I , Fernández Camila , Jayat Pablo 
Published: December 2024

Abstract
Patterns of morphometric variation of the skull in several species of mammals can be explained as adaptations to different environmental conditions and availability of food resources, as suggested by Bergmann’s rule and the resource rule hypothesis. A common and widely distributed species, Didelphis albiventris (the white-eared opossum), is an interesting model in which to study such patterns of variation and their ecological determinants. Using geometric morphometrics and a large sample of specimens (N = 185), we studied the relationship between the size and shape of the skull and several environmental variables. We observed a slight tendency for individuals from forested anthropogenic biomes to be smaller, but analyses performed to test for Bergman’s rule and the resource rules were statistically non-significant, and the analysis of the shape variance did not show any clear pattern. These results contrast with the pattern previously described for the species, showing that D. albiventris has a geographically unstructured generalist phenotype, in which the skull size does not follow any ecogeographical pattern, the variance of the skull shape is mostly influenced by size, and the effect of the environmental variables is small.
A pilot quality improvement initiative for lymph node dissection during lung cancer surgery
Authors: Thomas Pascal Alexandre , Braggio Cesare , Fourdrain Alex , Vasse Matthieu , Brioude Geoffrey , Trousse Delphine , Boulate David , Dales Jean-Philippe , Doddoli Christophe , Tomasini Pascale , D’journo Xavier Benoît , Greillier Laurent 
Published: December 2024

Abstract

OBJECTIVES
To evaluate the impact of a quality improvement initiative on intraoperative lymph node (LN) dissection adequacy.

METHODS
A single-centre cohort of 781 naïve patients who underwent resection of non-small cell lung cancer with pathological LN involvement and survived beyond 90 days was reviewed. LN dissection metrics were compared before and after the implementation of a quality improvement initiative. Quality metrics (QM) were: QM1 (≥10 LN examined), QM2 (≥3 intrapulmonary and hilar LN, ≥ 3 mediastinal stations, including station 7 in all cases), and QM3 (combination of QM1 and QM2).

RESULTS
The proportion of patients meeting QM1 did not differ significantly between the pre- (87.8%) and post-implementation (89.1%) periods. However, meeting QM2 and QM3 significantly improved from 79.5% to 88.6% (P = 0.001), and 76.2% to 84.4% (P = 0.007), respectively. Cox proportional hazard regression model for disease-free survival showed that patients operated on after the implementation of the quality improvement initiative exhibited better disease-free survival compared to those operated on before [adjusted hazard ratio (aHR): 0.73; 95% confidence interval (CI) 0.59–0.90; P = 0.003]. Nevertheless, none of these quality metrics influenced long-term outcomes. In contrast, adjuvant chemotherapy (aHR: 0.55; 95% CI 0.43–0.71; P &lt; 0.001) was associated with improved disease-free survival. In case of metastatic progression, immunotherapy improved overall survival (hazard ratio: 0.54; 95% CI 0.37–0.77; P = 0.0003).

CONCLUSIONS
Utilizing transparent data and collaborative feedback were effective to enhance the quality of nodal assessment in lung cancer surgery. Overall, long-term outcomes for patients with lymph node involvement was primarily associated with disease burden, adjuvant chemotherapy, and rescue immunotherapy.

IRB approval number
CERC-SFCTCV-2024-04-30_34750 on 30 April 2024.
Role of primary and secondary care data in atrial fibrillation ascertainment: impact on risk factor associations, patient management, and mortality in UK Biobank
Authors: Camm C Fielder , Von Ende Adam , Gajendragadkar Parag R , Pessoa-Amorim Guilherme , Mafham Marion , Allen Naomi , Parish Sarah , Casadei Barbara , Hopewell Jemma C 
Published: December 2024

Abstract

Aims
Electronic healthcare records (EHR) are at the forefront of advances in epidemiological research emerging from large-scale population biobanks and clinical studies. Hospital admissions, diagnoses, and procedures (HADP) data are often used to identify disease cases. However, this may result in incomplete ascertainment of chronic conditions such as atrial fibrillation (AF), which are principally managed in primary care (PC). We examined the relevance of EHR sources for AF ascertainment, and the implications for risk factor associations, patient management, and outcomes in UK Biobank.

Methods and results
UK Biobank is a prospective study, with HADP and PC records available for 230 000 participants (to 2016). AF cases were ascertained in three groups: from PC records only (PC-only), HADP only (HADP-only), or both (PC + HADP). Conventional statistical methods were used to describe differences between groups in terms of characteristics, risk factor associations, ascertainment timing, rates of anticoagulation, and post-AF stroke and death. A total of 7136 incident AF cases were identified during 7 years median follow-up (PC-only: 22%, PC + HADP: 49%, HADP-only: 29%). There was a median lag of 1.3 years between cases ascertained in PC and subsequently in HADP. AF cases in each of the ascertainment groups had comparable baseline demographic characteristics. However, AF cases identified in hospital data alone had a higher prevalence of cardiometabolic comorbidities and lower rates of subsequent anticoagulation (PC-only: 44%, PC + HADP: 48%, HADP-only: 10%, P &lt; 0.0001) than other groups. HADP-only cases also had higher rates of death [PC-only: 9.3 (6.8, 12.7), PC + HADP: 23.4 (20.5, 26.6), HADP-only: 81.2 (73.8, 89.2) events per 1000 person-years, P &lt; 0.0001] compared to other groups.

Conclusion
Integration of data from primary care with that from hospital records has a substantial impact on AF ascertainment, identifying a third more cases than hospital records alone. However, about a third of AF cases recorded in hospital were not present in the primary care records, and these cases had lower rates of anticoagulation, as well as higher mortality from both cardiovascular and non-cardiovascular causes. Initiatives aimed at enhancing information exchange of clinically confirmed AF between healthcare settings have the potential to benefit patient management and AF-related outcomes at an individual and population level. This research underscores the importance of access and integration of de-identified comprehensive EHR data for a definitive understanding of patient trajectories, and for robust epidemiological and translational research into AF.
High quality genome assembly and annotation (v1) of the eukaryotic freshwater microalga Coccomyxa elongata SAG 216-3b
Authors: Kraege Anton , Chavarro-Carrero Edgar , Schnell Eva , Heilmann-Heimbach Stefanie , Becker Kerstin , Köhrer Karl , Huettel Bruno , Sargheini Nafiseh , Schiffer Philipp , Waldvogel Ann-Marie , Thomma Bart P H J , Rovenich Hanna 
Published: December 2024

Abstract
Unicellular green algae of the genus Coccomyxa are recognized for their worldwide distribution and ecological versatility. Coccomyxa elongata is a freshwater species of the Coccomyxa simplex clade, which also includes lichen symbionts. To facilitate future molecular and phylogenomic studies of this versatile clade of algae, we generated a high-quality genome assembly for C. elongata Chodat & Jaag SAG 216-3b within the framework of the Biodiversity Genomics Center Cologne (BioC2) initiative. A combination of long-read PacBio HiFi and Oxford Nanopore Technologies with chromatin conformation capture (Hi-C) sequencing led to the assembly of the genome into 21 scaffolds with a total length of 51.4 Mb and an N50 of 2.8 Mb. Nineteen of the scaffolds represent highly complete nuclear chromosomes delimited by telomeric repeats, while the two additional scaffolds represent the mitochondrial and plastid genomes. Transcriptome-guided gene annotation resulted in the identification of 14,811 protein-coding genes, of which 61% have annotated protein family domains and 841 are predicted to be secreted. Benchmarking universal single-copy orthologs analysis against the Chlorophyta database identified a total of 1,494 (98.4%) complete gene models, suggesting a highly complete genome annotation.
Population pharmacokinetics/pharmacodynamics of minocycline plus rifampicin in patients with complicated skin and skin structure infections caused by MRSA
Authors: Pardos Sonia Luque , Hope William , Kotsaki Antigone , Das Shampa , Giamarellos-Bourboulis Evangelos J , Kontopoulouk Theano , Akinosoglou Karolina , O’Hare Miriam , Attwood Marie L G , Bowker Karen E , Noel Alan R , Lovering Andrew M , Bayliss Mark A J , Evans Rebecca N , MacGowan Alasdair P 
Published: December 2024

Abstract

Background
The population pharmacokinetics/pharmacodynamics (PK/PD) of minocycline, rifampicin and linezolid in patients with complicated skin and soft tissue infections (cSSTIs) caused by MRSA are described.

Methods
Samples were collected in a Phase 4 study of oral minocycline plus rifampicin versus linezolid showing minocycline plus rifampicin to be non-inferior to linezolid. Antibiotics were assayed by HPLC or LC-MS, and a population PK model was developed using Pmetrics. The association between PK/PD indices and patient outcomes was explored.

Results
A three-compartment model (with an absorption compartment) with first-order input and elimination best described the data for the three drugs. No covariates were included in the final model. The population median values (95% credibility limits) of the clearance and volume of distribution were 7.412 L/h (5.121–8.361) and 14.155 L (6.799–33.901) for minocycline, 5.683 L/h (3.703–7.726) and 7.736 L (6.031–8.948) for rifampicin, and 1.970 L/h (1.326–2.499) and 20.169 L (12.857–32.629) for linezolid, respectively. Maximum a posteriori probability-Bayesian estimation plots of observed versus predicted had a slope of 0.999 r20.967 for minocycline, slope 0.998 r20.769 for rifampicin and slope 0.998 r20.895 for linezolid. PK/PD indices were not related to clinical outcome. Taking a translational minocycline fAUC24h/MIC target of &gt;0.5 for minocycline in the presence of rifampicin, 96% (49/51) of patients reached the target.

Conclusions
Population PK models of minocycline, rifampicin and linezolid were developed in patients with MRSA cSSTI and almost all patients reached the predefined PD index targets. As a result, neither AUC, MIC nor the AUC/MIC ratio could be related to clinical outcome.
The Impact of Providing Training to Young Men on Labour Outcomes and Attitudes towards Migration in Northern Guinea-Bissau
Authors: Gamito Carlos Alberto Coca 
Published: December 2024

Abstract
The initial objective in this paper was to evaluate the impact of an integrated active labour market programme (ALMP) on young males’ labour market outcomes in the Bissau-Guinean regions of Cacheu and Oio. The programme had three elements—classroom vocational training, on-the-job training and business training. The intention was to evaluate the effects of each of these elements of the programme on employment, income and the propensity to migrate. A randomised controlled trial (RCT) was implemented with 302 young men who were eligible to participate in the programme, where 151 men were allocated to the treatment group and 151 men to the control group. Only eighty-five were compliant with the programme. This meant that sample sizes for the three elements of the programme became small. The three elements of the programme were combined to provide an estimate of the overall effect of the programme. Given the problem of compliance both the Intention-To-Treat effects (ITT) and the Average Treatment Effect (ATE) were estimated, the latter using instrumental variables. The ATE for the three outcomes were large. On average, participant's incomes increased by 70,000 XOF (106 EUR) and employment probability by some sixty percentage points. After treatment, only 2.4% of the participants had made arrangements to live permanently in another country, compared to 15.9% of individuals in the control group. Whilst it did not prove possible to identify which programme was most successful the results suggest that some aspects of the ALMP did achieve their objectives. A qualification to this positive finding is that a cost–benefit analysis showed it was relatively inefficient and costly. The return on investment (ROI) was −59.9%, and the benefit–cost ratio (BCR) 0.4, whilst similar ALMPs present a weighted average BCR equal to 2 and a weighted average ROI of 37.2%.