bluuebunny/crossref_metadata_2025_split huggingface dataset:
YAP nuclear‐cytoplasmic translocation is regulated by mechanical signaling, protein modification, and metabolism
Authors: Zou Rong , Xu Yahui , Feng Yifan , Shen Minqian , Yuan Fei , Yuan Yuanzhi 
Published: March 2020

AbstractNuclear‐cytoplasmic transport is necessary for the biological function of nuclear proteins. The mechanism underlying this process is very complex and has been a subject of intense research. Yes‐associated protein (YAP), a Hippo signaling pathway effector, localizes to both the cytoplasm and the nucleus and can influence cell proliferation, stem cell status, and tissue homeostasis. Recent studies have focused on the significance of YAP distribution between the nucleus and the cytoplasm in disease, but it remains unclear how this dynamic process is regulated. In this review, we discuss YAP nuclear‐cytoplasmic transport under different physiological and pathological conditions in terms of mechanical signaling, protein modification, and metabolism. Understanding the mechanisms underlying nuclear‐cytoplasmic YAP transport mechanism under different physiological and pathological conditions may help identify important targets for disease treatment.
Long‐term follow‐up after sirolimus‐coated balloon use for coronary artery disease. Final results of the Nanolutè study
Authors: El‐Mokdad Rami , di Palma Gaetano , Cortese Bernardo 
Published: March 2020

AbstractObjectivesTo test the long‐term efficacy of a sirolimus‐coated balloon (SCB).BackgroundNanoluté was a prospective registry to evaluate the clinical performance of a novel SCB (Concept Medical Research Private Limited, India) for the treatment of de novo coronary lesions and in‐stent restenosis (ISR). We here present the 24 months clinical data.MethodsAll patients treated with SCB for any type of coronary indication between July 2012 and September 2015 were enrolled at Indian centers and clinically followed up to 24 months. Primary endpoints were major adverse cardiovascular events (MACE) defined as a composite of cardiac death, target lesion revascularization (TLR), and target vessel‐myocardial infarction (MI).ResultsA total of 484 SCBs were used in 408 patients to treat 435 lesions. In detail, the SCB was used for 183 patients with ISR, 185 with de novo small vessel disease, and 40 with de novo large vessel disease. Mean balloon length and diameter (average ± SD) were 22.3 ± 7.1 mm and 2.7 ± 0.40 mm, respectively. All patients with 24 months follow‐up were included. Overall MACE rate was 4.2% (n = 17) with three cardiac deaths (0.7%), 13 TLR (3.2%), and one MI (0.2%).ConclusionThe Nanoluté prospective registry is the first long‐term clinical evidence of the safety and feasibility of this type of SCB, both in patients with ISR or de novo lesions.
Acupuncture induced pneumothorax: A case report
Authors: Shrestha Ninadini , Karki Bipin , Shrestha Pramesh Sunder , Gami Rupesh , Acharya Subhash Prasad , Dhakal Subodh Sagar 
Published: March 2020

AbstractVarious forms of alternative medicinal practices are gaining popularity. With this, there will be rise in the complications arising from these practices. Acupuncture is also such practice which though safe can rarely cause life‐threatening complications.
Layered hydrated vanadium oxide as highly reversible intercalation cathode for aqueous Zn‐ion batteries
Authors: Wang Pinji , Shi Xiaodong , Wu Zhuoxi , Guo Shan , Zhou Jiang , Liang Shuquan 
Published: March 2020

AbstractAqueous Zn‐ion batteries (ZIBs) hold great potential in large‐scale energy storage systems due to the merits of low‐cost and high safety. However, the unstable structure of cathode materials and sluggish (de)intercalation kinetics of Zn2+ pose challenges for further development. Herein, highly reversible aqueous ZIBs are constructed with layered hydrated vanadium oxide as a cathode material. The electrochemical performances are further tested with the optimized electrolyte of 3M Zn(CF3SO3)2 and a cut‐off voltage of 0.4 to 1.3 V, exhibiting a remarkable capacity of 290 mAh g−1 at 0.5 A g−1, and long‐term cycling stability at high current density. Furthermore, the Zn2+ storage mechanism of V3O7⋅H2O is recognized as a highly reversible (de)intercalation process with good structural stability, implying the potential application in the field of large‐scale energy storage.
Graphene‐based catalysts for electrochemical carbon dioxide reduction
Authors: Hasani Amirhossein , Teklagne Mahider Asmare , Do Ha Huu , Hong Sung Hyun , Van Le Quyet , Ahn Sang Hyun , Kim Soo Young 
Published: March 2020

AbstractElectrochemical carbon dioxide (CO2) reduction is considered to be an efficient strategy to produce usable fuels and overcome the concerns regarding global warming. For this purpose, an efficient, earth abundant, and a low cost catalyst has to be designed. It has been found that graphene‐based materials could be promising candidates for CO2 conversion because of their unique physical, mechanical, and electronic properties. In addition, the surface of graphene‐based materials can be modified by using different strategies, including doping, defect engineering, producing composite structures, and wrapping shapes. In this review, the fundamentals of electrochemical CO2 reduction and recent progress of graphene‐based catalysts are investigated. Furthermore, recent studies on graphene‐based materials for CO2 reduction are summarized.
Comparing the agronomic performance of short‐season and commonly grown corn hybrid maturities in Ohio
Authors: Lindsey Alexander J. , Minyo Richard , Geyer Allen B. , Thomison Peter R. 
Published: March 2020

AbstractPlanting short‐season corn (Zea mays L.) hybrids with maturity ratings earlier than those of hybrids commonly grown in Ohio (hereafter referred to as “ultra‐early” hybrids) might offer advantages in cover cropping systems by promoting an earlier corn harvest. Earlier harvest would facilitate earlier planting of cover crops or small grains to improve fall establishment. However, performance data related to yield and harvest moisture for ultra‐early hybrids is limited. A field study was conducted from 2016 to 2018 at two northern Ohio locations (Bucyrus and Wooster) to compare the agronomic performance and partial economic returns of ultra‐early hybrids with relative maturity ratings ranging from 90 to 100 d (∼2056–2450 growing degree days [GDDs]) to commonly grown hybrid maturities ranging from 104 to 109 d (∼2500–2600 GDDs). The ultra‐early hybrids incurred less drying costs and had higher test weights than the commonly grown maturity hybrids but yielded 9–10% less. Ultra‐early hybrids with ratings of 96–100 d yielded 3–5% more than those with ratings of 90 to 95 d. For late May and early June plantings, the partial return per acre for 96–100‐d hybrids did not differ from the commonly grown maturities due mainly to discounts from low test weights and high harvest moisture when harvested on the same date. The results suggest that growers could optimize profitability by planting the highest yielding early maturing hybrids and gain days of growth for potential cover crop establishment by planting ultra‐early hybrids.
Filling a Gap: The Coordinatively Saturated Group 4 Carbonyl Complexes TM(CO)8 (TM=Zr, Hf) and Ti(CO)7
Authors: Deng Guohai , Lei Shujun , Pan Sudip , Jin Jiaye , Wang Guanjun , Zhao Lili , Zhou Mingfei , Frenking Gernot 
Published: March 2020

AbstractHomoleptic Group 4 metal carbonyl cation and neutral complexes were prepared in the gas phase and/or in solid neon matrix. Infrared spectroscopy studies reveal that both zirconium and hafnium form eight‐coordinate carbonyl neutral and cation complexes. In contrast, titanium forms only the six‐coordinate Ti(CO)6+ and seven‐coordinate Ti(CO)7. Titanium octacarbonyl Ti(CO)8 is unstable as a result of steric repulsion between the CO ligands. The 20‐electron Zr(CO)8 and Hf(CO)8 complexes represent the first experimentally observed homoleptic octacarbonyl neutral complexes of transition metals. The molecules still fulfill the 18‐electron rule, because one doubly occupied valence orbital does not mix with any of the metal valence atomic orbitals. Zr(CO)8 and Hf(CO)8 are stable against the loss of one CO because the CO ligands encounter less steric repulsion than Zr(CO)7 and Hf(CO)7. The heptacarbonyl complexes have shorter metal−CO bonds than that of the octacarbonyl complexes due to stronger electrostatic and covalent bonding, but the significantly smaller repulsive Pauli term makes the octacarbonyl complexes stable.
A Sulfur‐Fixing Strategy toward Carbon‐Supported Ru‐Based Bimetallic Nanocluster Catalysts
Authors: Li Li‐Zhen , Xu Shi‐Long , Shen Shan‐Cheng , Wang Lei , Zuo Ming , Chen Ping , Liang Hai‐Wei 
Published: March 2020

AbstractSupported bimetallic nanocluster catalysts that are distinctly advantageous in optimizing the geometric/electronic effects and maximizing the metal atom utilization have attracted immense interest in the field of heterogeneous catalysis. However, the conventional impregnation techniques often cause poor dispersion of bimetallic particles even on high‐surface‐area supports owing to the lack of strong metal‐support interactions. Here, we present a general route to prepare Ru−M (M=Ga, In, Ge, Sn, Ni) bimetallic nanoclusters with average particle sizes of 1.02–1.24 nm by use of mesoporous sulfur‐doped carbon as supports. The strong chemical interaction between metal and the sulfur atoms that are doped in the carbon matrix can greatly suppress the aggregation of metal species during the H2‐reduction at 600 °C and thus guarantee the formation of small‐sized alloyed nanoclusters. Among these nanoclusters, the prepared bimetallic Ru−Sn nanocluster catalysts show enhanced catalytic activity for the selective hydrogenation of quinoline and furfural with a high turnover frequency of 2948 h−1 and 184 h−1, respectively.
Effective Recognition of Caffeine by Diaminocarbazolic Receptors
Authors: Francesconi Oscar , Ienco Andrea , Nativi Cristina , Roelens Stefano 
Published: March 2020

AbstractCaffeine is a competitive inhibitor of adenosine receptors and possesses wide pharmacological activity. Artificial receptors recognizing caffeine potentially have a wide range of biomedical and industrial applications. Herein, we describe two structurally related and readily available artificial receptors: 1) a macrocyclic receptor, which binds caffeine with the unprecedented affinity of 9.3 μM, though with poor selectivity; and 2) a tweezers‐like structure, showing an affinity of 26 μM and a 4.5‐fold and 6‐fold selectivity compared to theophylline and theobromine, respectively. Binding affinities were measured by 1H NMR titrations and were confirmed by isothermal titration calorimetry. The X‐ray structure of the complex between caffeine and the acyclic receptor revealed the origin of the recognition, explained the selectivity, and shed light on the role of hydrogen bonding and CH−π/π–π interactions.
Research Participant Views regarding Qualitative Data Sharing
Authors: Mozersky Jessica , Parsons Meredith , Walsh Heidi , Baldwin Kari , McIntosh Tristan , DuBois James M. 
Published: March 2020

ABSTRACTWe found no studies in the United States that explored research participants' perspectives about sharing their qualitative data. We present findings from interviews with 30 individuals who participated in sensitive qualitative studies to explore their understanding and concerns regarding qualitative data sharing. The vast majority supported sharing qualitative data so long as their data were deidentified and shared only among researchers. However, they raised concerns about confidentiality if the data were not adequately deidentified and about misuse by secondary users if data were shared beyond the research community. These concerns, though, did not deter them from participating in research. Notably, participants hoped their data would be shared and may have expected or assumed this was already happening. While many could not recollect details about data‐sharing plans for studies in which they participated, they trusted researchers and institutions to appropriately handle data sharing. If individuals view data sharing as an extension or integral part of their participation in qualitative research, then researchers may have a stronger obligation to share qualitative data than previously thought. Guidelines and tools to assist researchers and institutional review board members in ethical and responsible qualitative data sharing are urgently needed.
An analysis of metadata reporting in freshwater environmental DNA research calls for the development of best practice guidelines
Authors: Nicholson Andrew , McIsaac Daniel , MacDonald Caitlin , Gec Peter , Mason B. Eric , Rein William , Wrobel Jordan , de Boer Mats , Milián‐García Yoamel , Hanner Robert H. 
Published: March 2020

AbstractAs environmental DNA (eDNA) becomes more widely used in research, it becomes increasingly important to have a standard set of reporting guidelines for metadata. The unique properties of eDNA combined with the physical characteristics of the surrounding environment produce highly varied sampling conditions which can influence how an organism is detected. There are also various ways of quantifying and identifying species using eDNA, from sampling and filtering methods to extraction and genetic analysis. It is important to report sufficient metadata to account for this variability and allow for replication of the study. We conducted a systematic review of 160 eDNA studies to determine which data are reported and to assess whether these studies can be replicated. Focusing solely on freshwater studies, we developed a rubric to evaluate each study on 53 criteria based on previous analyses of eDNA research. We found a trend in the data suggesting better reporting at a broad scale, and decreased reporting as categories become more specific. Many of the metrics found to be insufficiently reported are essential to replicability. Our goal is to identify gaps in metadata reporting and develop a framework for developing standard reporting guidelines for eDNA studies.
Comparing short‐term outcome after implantation of the HeartWare® HVAD® and the Abbott® HeartMate 3®
Authors: Schramm Rene , Zittermann Armin , Morshuis Michiel , Schoenbrodt Michael , von Roessing Ellen , von Dossow Vera , Koster Andreas , Fox Henrik , Hakim‐Meibodi Kavous , Gummert Jan F. 
Published: March 2020

AbstractAimsCentrifugal continuous flow pumps are currently the state of the art in left ventricular assist device therapy. This study was conducted to compare the results after implantation of the HVAD® and the HeartMate 3®.Methods and resultsWe retrospectively analysed preoperative and post‐operative patient data of all 106 patients, who received a HeartMate 3 (HM3) at our centre between 2014 and 2018. A total of 392 patients receiving a sintered HVAD® served as controls. Patient matching was performed for age, sex, Interagency Registry for Mechanically Assisted Circulatory Support level at the time of implant, perioperative right heart failure, and implantation strategy, that is, bridge to transplant or destination therapy, as well as preoperative renal function, that is, as indicated by serum creatinine levels. A total of 79 matched pairs could be identified. During a median follow‐up of 15.3 months (range: 0–30 months), 23 (29.1%) and 19 (24.1%) patients died in the HVAD and HM3 groups, respectively, with a hazard ratio for mortality of 0.84 [95% confidence interval (CI): 0.46–1.54; P = 0.568]. Freedom from cerebrovascular events did not differ significantly between study groups, with a hazard ratio of 0.57 (95% CI: 0.23–1.45; P = 0.241). The risk of driveline infection was significantly lower in the HM3 (n = 33) than in the HVAD (n = 55) group (hazard ratio = 0.54; 95% CI: 0.35–0.84; P = 0.006). Eight HVAD, but no HM3, patients developed a pump thrombosis during follow‐up (P = 0.148).ConclusionsPerformance of both currently used centrifugal left ventricular assist device systems is comparable in terms of short‐term patient survival and freedom from cerebrovascular events. In our single‐centre experience, HM3 patients less frequently develop driveline infections and no pump thrombosis, which requires further evaluation.
The effect of iron deficiency on cardiac resynchronization therapy: results from the RIDE‐CRT Study
Authors: Lacour Philipp , Dang Phi Long , Morris Daniel Armando , Parwani Abdul Shokor , Doehner Wolfram , Schuessler Franziska , Hohendanner Felix , Heinzel Frank R. , Stroux Andrea , Tschoepe Carsten , Haverkamp Wilhelm , Boldt Leif‐Hendrik , Pieske Burkert , Blaschke Florian 
Published: March 2020

AbstractAimsCardiac resynchronization therapy (CRT) improves functional status, induces reverse left ventricular remodelling, and reduces hospitalization and mortality in patients with symptomatic heart failure, left ventricular systolic dysfunction, and QRS prolongation. However, the impact of iron deficiency on CRT response remains largely unclear. The purpose of the study was to assess the effect of functional and absolute iron deficiency on reverse cardiac remodelling, clinical response, and outcome after CRT implantation.Methods and resultsThe relation of iron deficiency and cardiac resynchronization therapy response (RIDE‐CRT) study is a prospective observational study. We enrolled 77 consecutive CRT recipients (mean age 71.3 ± 10.2 years) with short‐term follow‐up of 3.3 ± 1.9 months and long‐term follow‐up of 13.0 ± 3.2 months. Primary endpoints were reverse cardiac remodelling on echocardiography and clinical CRT response, assessed by change in New York Heart Association classification. Echocardiographic CRT response was defined as relative improvement of left ventricular ejection fraction ≥ 20% or left ventricular global longitudinal strain ≥ 20%. Secondary endpoints were hospitalization for heart failure and all‐cause mortality (mean follow‐up of 29.0 ± 8.4 months). At multivariate analysis, iron deficiency was identified as independent predictor of echocardiographic (hazard ratio 4.97; 95% confidence interval 1.15–21.51; P = 0.03) and clinical non‐response to CRT (hazard ratio 4.79; 95% confidence interval 1.30–17.72, P = 0.02). We found a significant linear‐by‐linear association between CRT response and type of iron deficiency (P = 0.004 for left ventricular ejection fraction improvement, P = 0.02 for left ventricular global longitudinal strain improvement, and P = 0.003 for New York Heart Association response). Iron deficiency was also significantly associated with an increase in all‐cause mortality (P = 0.045) but not with heart failure hospitalization.ConclusionsIron deficiency is a negative predictor of effective CRT therapy as assessed by reverse cardiac remodelling and clinical response. Assessment of iron substitution might be a relevant treatment target to increase CRT response and outcome in chronic heart failure patients.
New Directions for the Evaluation of Coalitions and Collaboratives
Authors: Brown Kyrah K. , Wolfe Susan M. , Price Ann Webb 
Published: March 2020

AbstractThis chapter summarizes the main points presented in the preceding chapters and highlights opportunities for advancing coalition evaluation. Four major suggestions for advancing coalition and collaborative evaluation are offered. First, there is a need for employing a systems/complexity perspective in coalition evaluation with associated frameworks and tools that can be applied in practice. Second, there is a need to incorporate principles of equity in coalition evaluation and to develop tools that can effectively capture processes and outcomes of equity‐focused work. Third, there is a need for more empirical research to advance the conceptualization, measurement, and evaluation of community coalitions and their collaborative efforts. Fourth, it is important that evaluators understand and employ best practices to foster collaborative and participatory evaluation processes within coalitions and collaboratives.
Evaluating Networks Using PARTNER: A Social Network Data Tracking and Learning Tool
Authors: Varda Danielle M. , Sprong Sara 
Published: March 2020

AbstractToday, cross‐sector partners are working together and utilizing a systems approach to solve and tackle complex social problems facing their communities. While building cross‐sector organizational networks has become a best practice in solving complex problems, there is little guidance or evidence on how it can be accomplished without overburdening resource‐stressed systems. Social network analysis (SNA) is one method for evaluating networks using a quantitative approach to measure the strength of connections, how organizations position themselves in a network, leverage resources, and assess the quality and impact of exchanges within the network. The PARTNER Tool (Program to Analyze, Record, and Track Networks to Enhance Relationships) leverages concepts of network science and SNA to provide a validated survey, measures, and analysis tool for network evaluation. The PARTNER methodology assesses the strengths (and gaps) among member relationships, how members perceive trust and value in partnerships, the creation of member relationships and how they have evolved, and identifies needs and gaps based on agreement on outcomes and success at reaching network goals. This chapter provides specific steps to implement the PARTNER Tool Methodology, including customizing the validating survey, administration of the online survey, analyzing the results using the PARTNER evaluation framework, and translating the data to actionable strategies. Real‐world examples are presented to highlight the benefits that can be achieved by leveraging network science with a focus on developing evidence‐based strategies that yield significant results and allow cross‐sector organizations to document their collective progress over time.
The effect of coenzyme Q10 supplementation on oxidative stress: A systematic review and meta‐analysis of randomized controlled clinical trials
Authors: Sangsefidi Zohreh Sadat , Yaghoubi Fatemeh , Hajiahmadi Salimeh , Hosseinzadeh Mahdieh 
Published: March 2020

AbstractSome evidence exists in supporting the beneficial effects of coenzyme Q10 (CoQ10) on oxidative stress. Since the findings of studies over the impact of CoQ10 supplementation on oxidative stress are contradictory, this study was conducted. The aim was to evaluate CoQ10 supplementation effect on total antioxidant capacity (TAC), malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) levels using data collected from randomized controlled trials (RCTs). Several databases including PubMed, Web of Science, Google Scholar, and Scopus were comprehensively searched up to 23 January 2019 to identify RCTs. A random‐effects model, standardized mean difference (SMD), and 95% confidence interval (CI) were applied for data analysis. According to the meta‐analysis results on 19 eligible studies, CoQ10 increased the levels of TAC (SMD = 1.29; 95% CI = 0.35–2.23; p = .007), GPX (SMD = 0.45; 95% CI = 0.17–0.74; p = .002), SOD (SMD = 0.63; 95% CI = 0.29–0.97; p < .0001), and CAT (SMD = 1.67; 95% CI = 0.29–3.10; p = .018) significantly. This supplementation also caused a significant reduction in MDA levels (SMD = −1.12; 95% CI = −1.58 to −0.65; p < .0001). However, the results of SOD and CAT should be stated carefully due to the publication bias. In conclusion, this research indicated that CoQ10 supplementation had beneficial effects on oxidative stress markers. However, further studies are needed to confirm these findings.