bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Population-Based Analysis of Intraoperative Cardiac Arrest in the United States
Authors: Fielding-Singh Vikram , Willingham Mark D. , Fischer Matthew A. , Grogan Tristan , Benharash Peyman , Neelankavil Jacques P. 
Published: October 2019

BACKGROUND:
A new billable code for intraoperative cardiac arrest was introduced with the International Classification of Diseases, Tenth Revision, classification system. Using a national administrative database, we performed a retrospective analysis of intraoperative cardiac arrest in the United States.

METHODS:
Hospital admissions involving patients ≥18 years of age who underwent operating room procedures in 2016 were identified using the National Inpatient Sample. The primary outcome was the incidence of intraoperative cardiac arrest. Secondary outcomes included total cost of admission, in-hospital mortality, length of stay, and identification of risk factors associated with intraoperative cardiac arrest. Clinical risk factors were evaluated with multivariable logistic regression models using sampling weights and adjustment for clustering by strata.

RESULTS:
Of 35,675,421 admissions in 2016 in the United States, 9,244,861 admissions were identified in patients ≥18 years of age who underwent at least one operating room procedure. An estimated 5230 hospital admissions involved intraoperative cardiac arrest, yielding an estimated incidence of 5.7 (95% confidence interval [CI], 5.3–6.0) per 10,000 hospital admissions. Admissions involving an intraoperative cardiac arrest had a 35.7% in-hospital mortality, compared with 1.3% for admissions without intraoperative cardiac arrest. Intraoperative cardiac arrest was associated with a 15.44-fold (95% CI, 12.74–18.70; P < .001) increase in the risk-adjusted odds of in-hospital mortality and an additional $13,184 (95% CI, 9600–16,769; P < .001) of total admission costs. Selected factors independently associated with increased risk-adjusted odds of intraoperative cardiac arrest included: black or missing race; cardiac, thoracic, or vascular surgery; congestive heart failure; pulmonary circulation disorders; peripheral vascular disease; end-stage renal disease; and fluid and electrolyte disorders.

CONCLUSIONS:
In this population-based study of intraoperative cardiac arrest in the United States, admissions involving an intraoperative cardiac arrest were rare but were associated with high in-hospital mortality.
Two conserved glycine residues in mammalian and Dictyostelium Rictor are required for mTORC2 activity and integrity
Authors: Pergolizzi Barbara , Panuzzo Cristina , Ali M. Shahzad , Lo Iacono Marco , Levra Levron Chiara , Ponzone Luca , Prelli Marta , Cilloni Daniela , Calautti Enzo , Bozzaro Salvatore , Bracco Enrico 
Published: October 2019

ABSTRACT
Mammalian, or mechanistic, target of rapamycin complex 2 (mTORC2) regulates a variety of vital cellular processes, and its aberrant functioning is often associated with various diseases. Rictor is a peculiar and distinguishing mTORC2 component playing a pivotal role in controlling its assembly and activity. Among extant organisms, Rictor is conserved from unicellular eukaryotes to metazoans. We replaced two distinct, but conserved, glycine residues in both the Dictyostelium piaA gene and its human ortholog, RICTOR. The two conserved residues are spaced ∼50 amino acids apart, and both are embedded within a conserved region falling in between the Ras-GEFN2 and Rictor­_V domains. The effects of point mutations on the mTORC2 activity and integrity were assessed by biochemical and functional assays. In both cases, these equivalent point mutations in the mammalian RICTOR and Dictyostelium piaA gene impaired mTORC2 activity and integrity. Our data indicate that the two glycine residues are essential for the maintenance of mTORC2 activity and integrity in organisms that appear to be distantly related, suggesting that they have a evolutionarily conserved role in the assembly and proper mTORC2 functioning.
CHINA SURVEY OF FITNESS TRENDS FOR 2020
Authors: Li Yong-Ming , Han Jia , Liu Yang , Wang Ran , Wang Ru , Wu Xue-Ping , Cao Zhen-Bo 
Published: October 2019

Apply It!
• Nation specificity of fitness trends should be considered by international fitness organizations or companies when making strategic plans in other countries.
• Ten trends can be recognized as the current stable trends within the health/fitness industry in China.
BRAZIL AND ARGENTINA SURVEY OF FITNESS TRENDS FOR 2020
Authors: Amaral Paulo Costa , Palma Deborah D. 
Published: October 2019

Apply It!
From this article, the reader should understand the following concepts:
• Use the fitness trends of Brazil and Argentina in commercial, corporate, and clinical (including medical fitness) sectors; universities; and fitness for community health industry to further promote physical activity.
•Know the fitness markets of Brazil and Argentina.
The Basics of Training for Muscle Size and Strength: A Brief Review on the Theory
Authors: BUCKNER SAMUEL L. , JESSEE MATTHEW B. , MOUSER J. GRANT , DANKEL SCOTT J. , MATTOCKS KEVIN T. , BELL ZACHARY W. , ABE TAKASHI , LOENNEKE JEREMY P. 
Published: October 2019

ABSTRACT
The periodization of resistance exercise is often touted as the most effective strategy for optimizing muscle size and strength adaptations. This narrative persists despite a lack of experimental evidence to demonstrate its superiority. In addition, the general adaptation syndrome, which provides the theoretical framework underlying periodization, does not appear to provide a strong physiological rationale that periodization is necessary. Hans Selye conducted a series of rodent studies which used toxic stressors to facilitate the development of the general adaptation syndrome. To our knowledge, normal exercise in humans has never been shown to produce a general adaptation syndrome. We question whether there is any physiological rationale that a periodized training approach would facilitate greater adaptations compared with nonperiodized approaches employing progressive overload. The purpose of this article is to briefly review currently debated topics within strength and conditioning and provide some practical insight regarding the implications these reevaluations of the literature may have for resistance exercise and periodization. In addition, we provide some suggestions for the continued advancement within the field of strength and conditioning.
Physical Activity and Genome-wide DNA Methylation: The REgistre GIroní del COR Study
Authors: FERNÁNDEZ-SANLÉS ALBA , SAYOLS-BAIXERAS SERGI , CASTRO DE MOURA MANUEL , ESTELLER MANEL , SUBIRANA ISAAC , TORRES-CUEVAS SEBASTIÁN , PÉREZ-FERNÁNDEZ SILVIA , ASLIBEKYAN STELLA , MARRUGAT JAUME , ELOSUA ROBERTO 
Published: October 2019

ABSTRACT

Introduction
DNA methylation may be one of the biological mechanisms underlying the health benefits of physical activity (PA). Our objective was to determine the association between PA and genome-wide DNA methylation at CpG level.

Methods
We designed a two-stage epigenome wide association study. In the discovery stage, we used 619 individuals from the REgistre GIroní del COR cohort. Next, we validated the CpG suggestively associated with PA (P < 10−5) in two independent populations (n = 1735 and 190, respectively). Physical activity was assessed with validated questionnaires and classified as light PA (LPA), moderate PA, vigorous PA, moderate-vigorous PA (MVPA) and total PA. We examined linear and nonlinear associations and meta-analyzed the results in the three populations. The linear associations were meta-analyzed with a fixed-effects model and the P values of the nonlinear associations with the Stouffer and Fisher methods. We established a P value threshold that fulfilled Bonferroni criteria over the number of CpG analyzed (0.05/421,940 = 1.185 × 10−7).

Results
In the meta-analyses, two CpG sites had a statistically significant nonlinear association with MVPA. cg24155427 (P = 1.19 × 10−9), located in an intergenic region in chromosome 1, has been previously associated with smoking, lupus, and aging. cg09565397 (P = 1.59 × 10−7), located within DGAT1 in chromosome 8, which encodes an enzyme involved in triacylglycerol synthesis.

Conclusions
This population-based study identified two new, differentially methylated CpG sites with a nonlinear dose–response relationship to MVPA. These associations must be additionally validated and may be considered for further research on the biological mechanisms underlying health benefits of PA.
Accelerometer-measured Physical Activity, Reproductive Hormones, and DNA Methylation
Authors: WU YUE , GOODRICH JACLYN M. , DOLINOY DANA C. , SÁNCHEZ BRISA N. , RUIZ-NARVÁEZ EDWARD A. , BANKER MARGARET , CANTORAL ALEJANDRA , MERCADO-GARCIA ADRIANA , TÉLLEZ-ROJO MARTHA M. , PETERSON KAREN E. 
Published: October 2019

ABSTRACT

Introduction/Purpose
Limited studies have examined the association of physical activity with reproductive hormones, DNA methylation, and pubertal status among adolescents.

Methods
Among 248 boys and 271 girls, we estimated daily physical activity levels based on 7 d of wrist-worn accelerometer data. We used an isotemporal substitution paradigm and sex-stratified regression models to examine the association of physical activity levels with 1) testosterone, cortisol, progesterone, and androstenedione concentrations; 2) DNA methylation of long interspersed nucleotide (LINE-1) repeats and the genes H19, hydroxysteroid (11-Beta) dehydrogenase 2 (HSD11B2), and peroxisome proliferator-activated receptor alpha (PPARA) from blood leukocytes; and 3) Tanner stages, adjusted for age, BMI, and socioeconomic status.

Results
In boys, substituting 30 min of moderate physical activity for 30 min of sedentary behavior per day was associated with 29% (−49%, 0%) of lower testosterone and 29% (4%, 61%) of higher progesterone. Substituting 30 min of light physical activity for sedentary behavior was associated with 13% (−22%, −2%) of lower progesterone. Among girls, 30 min of additional sedentary behavior was associated with 8% (−15%, 0%) of lower testosterone and 24% (8%, 42%) of higher progesterone concentrations. Substituting 30 min of moderate physical activity for sedentary behavior was associated with 15% (0%, 31%) of higher cortisol, whereas substituting the same amount of light physical activity for sedentary behavior was associated with 22% (−39%, 0%) of lower progesterone. Substituting 30 min of vigorous physical activity for sedentary behavior per day was associated with almost six times higher levels (5.83, 95% confidence interval = 1.79–9.86) of HSD11B2 methylation in boys.

Conclusions
Accelerometer-measured daily physical activity was associated with reproductive hormones and HSD11B2 DNA methylation, differed by sex and activity intensity levels.
Drug-Induced Autoimmune Hepatitis From Hydralazine Leading to Acute Liver Failure and Liver Transplantation
Authors: Grewal Jasleen , Doan Angela , Hong Annie S. , Amin Arpit , Scapa Jason V. , Hanna Ramy , Durazo Francisco , Yanny Beshoy 
Published: October 2019

ABSTRACT
We describe a woman with no previous liver disease who developed drug-induced autoimmune hepatitis from hydralazine prescribed to her for hypertension. Despite the discontinuation of the medication, she developed acute liver failure and subsequently underwent successful liver transplantation. She survived and had a good clinical outcome.
Hemodynamic Instability Secondary to Inferior Vena Cava Compression: A Rare Complication of Massive Walled-off Pancreatic Necrosis
Authors: Goyal Tanvi , Javaid Toseef , Goyal Anirudh , Khan Zubair 
Published: October 2019

ABSTRACT
Necrosis developing 4 weeks after the initial acute pancreatitis attack is known as walled-off pancreatic necrosis (WOPN). Complications of WOPN include spontaneous rupture into the peritoneal cavity or hollow viscus obstruction by compression of surrounding structures, including the colon, stomach, duodenum, and common bile duct. There have also been cases of pseudocyst rupture into blood vessels. This case report is unique in that it highlights a patient with inferior vena cava compression leading to hemodynamic instability due to the mass effect of WOPN and has not been previously reported.
Fractura de roca andesita y análisis espectral de señales de emisión acústica
Authors: Filipussi Dino Alberto , Muszkats Juan Pablo , Sassano Miryam Patricia , Zitto Miguel Eduardo , Piotrkowski Rosa 
Published: October 2019

Contexto: En las rocas sometidas a esfuerzos se producen señales de emisión acústica (EA). Esta y la información sísmica son complementarias tanto en sus aplicaciones como en su base teórica. Por ende, el estudio de frecuencias características en las señales de emisión acústica tiene relevancia para comprender la propagación de ondas sísmicas en la Tierra.
Método: Se realizó un ensayo de compresión uniaxial en probetas cilíndricas de roca andesita, llevadas hasta la rotura. Se registraron las señales de EA obtenidas durante el ensayo. Un análisis de las frecuencias de estas señales cabe en el contexto de un modelo elemental de foco sísmico, el cual describe el avance y la propagación de ondas durante la fractura de un material frágil. A partir de los espectros de Fourier de las señales, convenientemente representados en escala logarítmica, se obtiene la frecuencia esquina. Este parámetro da cuenta del tamaño de las fisuras durante el avance del daño en el material sometido a esfuerzo.
Resultados: En un primer análisis se determinó la frecuencia esquina. En un segundo análisis, se filtraron las señales para distintas bandas de frecuencias con transformada Wavelet y se obtuvo el Wavelet Energy b-value (bWE) correspondiente.
Conclusiones: El estudio de la evolución del bWE para las distintas bandas de frecuencia permitió determinar frecuencias características que se pueden asociar a distintos mecanismos de fracturas en las rocas.
Análisis Bibliométrico de la Revista Ingeniería (2010-2017)
Authors: Suárez Roldan Carolina , Chaparro Nathalia , Rojas-Galeano Sergio 
Published: October 2019

Contexto: Ingeniería es una revista científica editada en Colombia por la Universidad Distrital Francisco José de Caldas, que publica investigación multidisciplinaria en todos los campos de la ingeniería. El objetivo de este trabajo es realizar un análisis bibliométrico de su producción científica durante el período 2010-2017.
Método: Se examinó un corpus de 144 artículos publicados, se recopilaron sus metadatos bibliográficos y se realizaron varios análisis bibliométricos, incluidos productividad, autoría, citas, cobertura geográfica y temática, redes de colaboración, mapas conceptuales temáticos y métricas de impacto.
Resultados: Entre los resultados se encuentran: promedio de citas por artículo de 2.1, índice de colaboración de 2.22, tasa de crecimiento de publicación es 19 %, h-index de h = 10, g-index de g = 13, hi5-index de hi5 = 9, el total de citas es de 298, hay diez grupos de autores muy conectados y cuatro grupos temáticos obtenidos a partir del análisis de coincidencia de las palabras clave y los resúmenes.
Conclusiones: El perfil de la revista con respecto a citaciones e impacto es prometedor, aunque requiere mejorar su visibilidad y reconocimiento, ya que las métricas de cobertura, autoría y áreas temáticas, parecen incipientes. También es deseable ampliar las redes de colaboración de su base de autores.
Assessing hospital readiness for radio frequency identification device implementation in Iran: a conceptual model
Authors: Sadeghi Malihe , Rahmati Pakzad , Pour Zahra Ramezani , Goharinejad Elham , Kahouei Mehdi 
Published: October 2019

Abstract

Background
To avoid possible failures and ineffective use of economic resources, necessary infrastructure must be provided before implementing new technologies in a developing country like Iran.

Objectives
To assess the degree of readiness for implementing a radio frequency identification device (RFID) system in hospitals in Iran.

Methods
We adopted a descriptive design and structural equation modeling (LISREL statistical software package) to analyze data collected from the hospitals affiliated with the Semnan University of Medical Sciences. All managers, physicians, residents, nurses, and staff members of the medical records and information technology sectors participated in this study. A questionnaire was designed by the investigators to collect ideas from the participants about organizational readiness, cultural readiness, and human resource readiness in implementing RFID.

Results
We found a significant positive correlation between the variables studied. Human resource readiness significantly predicted RFID implementation, with cultural readiness playing the role of a mediator variable. Cultural readiness itself was influenced by organizational readiness (P < 0.01). We found 0.346 (standard deviation: 0.374) changes in an arbitrary unit of the possibility of RFID implementation was attributed to human resources and cultural readiness.

Conclusions
Paying attention to cultural factors, which play an important role in implementing technological projects such as RFID in developing countries like Iran, can reduce the risk of failure. Hospitals should strengthen organizational factors and improve the support of top rank managers when implementing technological projects. By so doing, they will promote cultural readiness, prepare human resources, and win the cooperation of personnel for such projects.
On reproduction in Crouania pumila (Callithamniaceae, Rhodophyta), a new record for the Red Sea
Authors: Hoffman Razy 
Published: October 2019

Abstract
The minute red alga Crouania pumila (Callithamniaceae: Rhodophyta), recently described from the Caribbean Sea, is reported for the first time from the Red Sea, approximately 12,000 km from the type locality, based on microscope slide specimens collected 40 years ago by Dr. Yaacov Lipkin. These samples contribute new information regarding the reproduction of this algal species.
Microalgal blooms in a eutrophic estuary (Golden Horn, Sea of Marmara) following a remediation effort
Authors: Tas Seyfettin 
Published: October 2019

Abstract
The present work describes microalgal blooms that occurred in a eutrophic estuary (Golden Horn, Sea of Marmara, Turkey) between October 2013 and September 2014 following a remediation effort. The relationships between bloom-forming microalgal species and environmental factors were investigated during the study period. The changing environmental conditions (e.g. increasing water transparency and salinity) after seawater transfer to the Golden Horn Estuary stimulated phytoplankton growth with dense algal blooms. Annual average values of Secchi depth, salinity and dissolved oxygen increased in comparison with those in an earlier study in 2009–2010. Nine microalgal species, which consisted of four diatoms, two dinoflagellates, one cryptophycean, one raphidophycean and one euglenophycean, formed the blooms with water discolorations during spring and summer. The species that reached the highest bloom density were Plagioselmis prolonga (62.4 × 106 cells l−1) among crytophyceans, Heterocapsa triquetra (21.8 × 106 cells l−1) among dinoflagellates and Skeletonema marinoi (39 × 106 cells l−1) among diatoms. The abundance of dinoflagellates and phytoflagellates increased particularly in the upper estuary when compared to diatoms and their rapid growth and bloom formation revealed that they have a wide range of tolerance to changing environmental conditions and a strong ability to compete with other species in this study area.
Application of the Euler and Runge–Kutta Generalized Methods for FDE and Symbolic Packages in the Analysis of Some Fractional Attractors
Authors: Milici Constantin , Tenreiro Machado José , Drăgănescu Gheorghe 
Published: October 2019

Abstract
This paper applies the Euler and the fourth-order Runge–Kutta methods in the analysis of fractional order dynamical systems. In order to illustrate the two techniques, the numerical algorithms are applied in the solution of several fractional attractors, namely the Lorenz, Duffing and Liu systems. The algorithms are implemented with the aid of Mathematica symbolic package. Furthermore, the Lyapunov exponent is obtained based on the Euler method and applied with the Lorenz fractional attractor.
Determination of indirect reference intervals of vitamin B12 for outpatients admitted to primary healthcare centers
Authors: Avci Esin , Aslan Diler 
Published: October 2019

Abstract

Background
Vitamin B12 deficiency is still an important nutritional problem worldwide. There is no consensus on the reference intervals (RIs) for vitamin B12. In order to establish vitamin B12 RIs, we used the database obtained from a primary healthcare organization and estimated region-specific intervals.

Methods
Vitamin B12 results were collected from our laboratory information system (LIS) between January 2014 and July 2014. We excluded the results of the individuals who had megaloblastic and microcytic anemia. After outlier detection and exclusion, we estimated the RIs of the “1–12, 13–18, 19–64 and 65 +” age groups according to the International Federation of Clinical Chemistry (IFCC) method. Statistical differences were examined between groups.

Results
The reference limits and 90% confidence intervals (CIs) (n = 14,748, 3790 male, age: 1–96; 10,958 female, age: 1–115) were estimated with 90% CIs as 106 (104–107)–393 (391–395) pmol/L. We also estimated the reference limits of the “1–12, 13–18, 19–64 and 65 +” age groups to be 127–459, 108–398, 106–384 and 104–426 pmol/L, respectively. There was no difference between genders in all age groups.

Conclusions
Both the lower and upper limits of the estimated RIs were found to be lower than the reference limits recommended by the manufacturer. Our findings revealed that the RIs of vitamin B12 should be given for the “1–12, 13–18, 19–64 and 65 +” age groups separately. The big data obtained from laboratories should be used for the determination of its population health status. As our population is composed of outpatients, the estimated vitamin B12 RIs may establish the basic information for the examination of our population for vitamin B12 deficiency.
Crystal structure of methyl (E)-N
2-((3-methylquinolin-8-yl)sulfonyl)-Nω′-nitro-L-argininate - ethanol (1/1), C19H28N6O7S
Authors: Jiang Binli , Zhou Guo-Chun 
Published: October 2019

Abstract
C19H28N6O7S, monoclinic, P21 (no. 4), a = 8.1573(1) Å, b = 17.4823(1) Å, c = 9.1162(1) Å, β = 116.432(1)°, V = 1164.14(2) Å3, Z = 2, R
gt(F) = 0.0273, wR
ref(F
2) = 0.0732, T = 170(2) K.
The crystal structure of bis(μ2-5,7-dichloroquinolin-8-olato-κ3
N,O:O)-tetrakis(5,7-dichloroquinolin-8-olato-κ2
N,O)bis(methanol-κ1
O)dieuropium(III) — toluene (1/1), C63H39Cl12Eu2N6O8
Authors: Alexander Orbett T. , Brink Alice , Visser Hendrik G. 
Published: October 2019

Abstract
C63H39Cl12Eu2N6O8, triclinic, P1̄ (no. 2), a = 10.720(5) Å, b = 12.232(5) Å, c = 14.267(5) Å, α = 65.288(32)°, β = 71.325(5)°, γ = 88.067(5)°, V = 1599.1(11) Å3, Z = 1, Rgt
(F) = 0.0358, wR
ref(F
2) = 0.0785, T = 293(2) K.
Crystal structure of catena-poly[aqua(μ4-piperazine-1,4-bis(2-hydroxypropanesulfonato-κ8
O,O′:O′,N:N′,O′′:O′′,O′′′))silver(I)], C10H24Ag2N2O10S2
Authors: Jiang Jin-Ke , Xu Xin-Yue , Li Xi-Xi , Du Jing-Jie , Jiang Hui , Dong Xian-Wu 
Published: October 2019

Abstract
C10H24Ag2N2O10S2, triclinic, P1̄ (no. 2), a = 6.9547(9) Å, b = 8.4684(12) Å, c = 8.9563(15) Å, α = 117.888(15)°, β = 101.740(13)°, γ = 93.026(11)°, V = 449.75(13) Å3, Z = 1, R
gt(F) = 0.0365, wR
ref(F
2) = 0.0858, T = 293(2) K.