bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating multiple experimental data to determine conformational ensembles of an intrinsically disordered protein
Authors: Gomes Gregory-Neal W. , Krzeminski Mickaël , Namini Ashley , Martin Erik. W. , Mittag Tanja , Head-Gordon Teresa , Forman-Kay Julie D. , Gradinaru Claudiu C. 
Published: February 2020

AbstractIntrinsically disordered proteins (IDPs) have fluctuating heterogeneous conformations, which makes structural characterization challenging, but of great interest, since their conformational ensembles are the link between their sequences and functions. An accurate description of IDP conformational ensembles depends crucially on the amount and quality of the experimental data, how it is integrated, and if it supports a consistent structural picture. We have used an integrative modelling approach to understand how conformational restraints imposed by the most common structural techniques for IDPs: Nuclear Magnetic Resonance (NMR) spectroscopy, Small-angle X-ray Scattering (SAXS), and single-molecule Förster Resonance Energy Transfer (smFRET) reach concordance on structural ensembles for Sic1 and phosphorylated Sic1 (pSic1). To resolve apparent discrepancies between smFRET and SAXS, we integrated SAXS data with non-smFRET (NMR) data and reserved the new smFRET data for Sic1 and pSic1 as an independent validation. The consistency of the SAXS/NMR restrained ensembles with smFRET, which was not guaranteed a priori, indicates that the perturbative effects of NMR or smFRET labels on the Sic1 and pSic1 ensembles are minimal. Furthermore, the mutual agreement with such a diverse set of experimental data suggest that details of the generated ensembles can now be examined with a high degree of confidence to reveal distinguishing features of Sic1 vs. pSic1. From the experimentally well supported ensembles, we find they are consistent with independent biophysical models of Sic1’s ultrasensitive binding to its partner Cdc4. Our results underscore the importance of integrative modelling in calculating and drawing biological conclusions from IDP conformational ensembles.
The impact of market orientation on innovativeness: evidence from Yemeni SMEs
Authors: Alhakimi Wail , Mahmoud Mohammed 
Published: February 2020

Purpose
This study aims to investigate the impact of market orientation on small and medium-sizedenterprises (SMEs) innovativeness in Yemen.

Design/methodology/approach
The study uses empirical data collected from 206 managers, owners and operators of SME in Sana'a. By using exploratory and quantitative methods, the collected data was examined using descriptive, correlation and regression analyses.

Findings
The results indicated that market orientation, as a whole, has a significant impact on SME innovativeness. Specifically, while the two dimensions – customer orientation and supplier orientation – have a significant impact on SME innovativeness, the other two dimensions – competitor and inter-functional coordination – do not have a significant impact on SME innovativeness.

Research limitations/implications
The study focuses only on four factors that have an influence over SME innovativeness based on the perspective of managers.

Practical implications
SMEs represent the largest portion of businesses in Yemen’s private sector. It is anticipated that the findings of this study will help SMEs’ owners and managers to better understand market orientation and the significant impact it has on SME innovativeness.

Originality/value
The value of this research work is evident from the fact that the market orientation models have neglected the part of suppliers (upstream supply chain) in generating superior value for customers, even though they have concentrated on the role of customers (downstream supply chain) and competitors.
Earnings management prior to private debt issuance
Authors: Ater Brandon , Hansen Thomas Bowe 
Published: February 2020

Purpose
The purpose of this paper is to evaluate the extent to which firms manage earnings prior to private debt issuance.

Design/methodology/approach
This is an empirical archival research paper using financial statement data and data related to private debt issuance.

Findings
The results indicate that, on average, firms engage in income-increasing earnings management in the period prior to a new private debt issuance. In addition, it was found that this income-increasing earnings management is limited to firms which have engaged in income-increasing earnings management to a greater extent in prior years.

Research limitations/implications
This paper provides insight into how managers’ balance competing incentives to use income-increasing earnings management to obtain more favorable lending terms, and to use income-decreasing earnings management to reduce the risk of a future debt covenant violation. The results indicate that firms’ incentive to use income-increasing earnings management dominates. However, reputational concerns significantly constrain firms’ earnings management decisions prior to private debt issuance.

Originality/value
The paper fills a notable void in the literature by investigating firms’ earnings management activity prior to private lending agreements, and thereby provides new insights into both the relation between private debt and accounting quality, and the literature investigating the use of earnings management to avoid debt covenant violations.
Why information technology is constrained in tackling tax noncompliance in developing countries
Authors: Umar Mohammed Abdullahi , Masud Abdulsalam 
Published: February 2020

PurposeThis study aims to investigate the reasons for the large scale tax noncompliance prevalent in underdeveloped countries despite many years of information technology (IT)-led tax administration reforms.Design/methodology/approachThe study is based on in-depth interviews with 18 senior tax administration officials. Their experiences were used to construct a grounded theory to explain the constraint of IT in tackling the prevalent tax noncompliance in underdeveloped countries.FindingsFirst, IT is not immune to the systemic corruption prevalent in many developing countries; hence, it is quickly compromised. Second, IT can be efficient in dealing with registered taxpayers but cannot deal with the overwhelming large numbers of operators in the informal sector. Third, E-tax administration, which is a hallmark of IT-led tax administrations in advanced countries, is very slow to catch up in developing countries. A computerized tax administration alone, as currently obtainable in developing countries, is not enough to engender large usage of e-filing. Businesses, especially small and medium-sized enterprises (SMEs), need IT infrastructure as well to align with tax administration. Unfortunately, basic IT infrastructure is yet to be available to a large section of SMEs in developing countries.Research limitations/implicationsUnderdeveloped countries are diverse. This study is from a single country and there may be need to take note of other countries’ peculiarities. However, Nigeria constitutes a good case study.Practical implicationsThere is need to reform the people and systems along with IT originality/value.Originality/valueTo the authors’ knowledge, this study is the first to explore this very important question and among the first to explore tax administrators’ perspectives.
Strategic alliances’ effects over hospital efficiency and capacity utilization in México
Authors: Giménez Víctor , Prior Diego , Keith Jorge R. 
Published: February 2020

PurposeThis paper aims to investigate the efficiency implications of belonging to a strategic hospital alliance (SHA) and measuring the effects over capacity utilization of such agreements in a Mexican healthcare context.Design/methodology/approachData Envelopment Analysis (DEA) is the nonparametric methodology used, which supports both objectives. Technological gaps ratios are calculated by using DEA-metafrontier approach to compare efficiency between SHA members and a hospital’s control group. Also, hospital capacity utilization ratios are used as the maximum rate of output possible from fixed inputs in a frontier setting using directional distance functions. Data were collected from an alliance called Consorcio Mexicano de Hospitales in México, which has 29 general private hospitals and a group of 47 hospitals with same characteristics from a database made by the Instituto Nacional de Estadística y Geografía for year 2014.FindingsThe results indicate that efficiency is better at hospitals that belong to an alliance; it also shows an improvement of installed capacity management for hospital alliances in México.Originality/valueThe results can be useful for both private health organization managers and regulators themselves to adopt management practices that may end up having a favorable impact on cost and prices containment. Additionally, there are no previous studies neither in Mexico nor in Latin America that analyze the impact of strategic hospitality alliances on the efficiency and utilization of the capacity of private hospitals.
A method to encourage and assess innovations in public tenders for infrastructure and construction projects
Authors: Lenderink Bart , Halman Johannes I.M. , Boes Hans , Voordijk Hans 
Published: February 2020

PurposeStimulating innovation in projects can contribute to achieving policy goals, addressing societal challenges and meeting objectives within programs and projects. Despite their potential, innovations are rarely included in tender assignments and evaluated in the award of civil engineering projects. One explanation for this is the perceived difficulty in triggering and objectively assessing innovations in the awarding of projects. The aim of this paper is to develop, implement and evaluated a method to encourage and assess innovations in the awarding of bridge construction projects to address this problem.Design/methodology/approachA design science research (DSR) approach is used to develop, implement and evaluate a method to trigger and assess innovations in tenders for bridge projects. DSR approaches are used to develop “well-tested, well-understood and well documented innovative generic designs, dealing with authentic field problems or opportunities” (van Akenet al., 2016).FindingsThe findings show that the application of the developed method in a bridge project led to the inclusion of a broad range of innovations in the tender offers. Despite the broad support for the defined criteria, there were some differences in the way the criteria were interpreted by the public procurement team and by the tenderers. Despite these differences, no legal claims were filed in court.Practical implicationsFurther development and wider adoption of the method is likely to have a positive impact on the application of innovations in bridge projects. With some adjustments, the method would also be appropriate for other civil engineering and construction projects.Originality/valueThis paper contributes to the discussion on how the terms innovation and innovativeness can be operationalized and used in the literature and practice. The developed method provides definitions for assessing the degree as well as the level of innovations in tenders for bridge projects. Further, it provides a way to rank innovations and determine the additional value of the offered innovations in terms of a notional reduction in tender price. Finally, it provides insights into how to encourage innovations through public procurement in civil engineering projects.
Workplace friendship, psychological safety and innovative behavior in China
Authors: Cao Feiyuan , Zhang Haomin 
Published: February 2020

PurposeThis paper aims to clarify the influences of workplace friendship, psychological safety on employees’ innovative behavior and the moderated role of transformational leadership and face.Design/methodology/approachThe current research proposes and tests a theoretic framework to explore the mechanism of workplace friendship in influencing employees’ innovative behavior. Based on a sample of 441 respondents from various Chinese companies, this paper used SPSS 22.0 and Amos 22.0 to examine the hypotheses.FindingsResults indicate that workplace friendship positively related to innovative behavior and psychological safety functioned as a mediator between them. Moreover, it examines the moderating roles of transformational leadership and face. Transformational leadership and desire to gain face strengthen the relationship between psychological safety and employees’ innovative behavior but fear of losing face is negatively related to the strength of this relationship.Originality/valueThe current research is meaningful for managerial practice. Then, the theoretical framework will contribute to providing a new perspective for understanding complex friendship at studies thus explore its boundary conditions, which help to lead to desirable outcomes. Besides, the findings advance nascent theory on face under oriental culture background.
Numerical modelling of heat transfers between inductively heated metallic and dielectric phases
Authors: Bourrou Rémi , Budenkova Olga , Lafon Christophe , Gagnoud Annie 
Published: February 2020

Purpose
Heating with a low-frequency induction is a key phenomenon in a process dedicated to the treatment of nuclear wastes. This paper aims to present a step of the numerical model being developed to study this process.

Design/methodology/approach
A hydrodynamic model for the processing of a liquid charge consisting of a metallic phase and a dielectric one is developed based on a volume of fluid (VOF) approach coupled with electromagnetic calculations. The latter allows one to calculate the distribution of the Joule heating in the setup and radiative heat exchange inside the crucible is accounted with a surface-to-surface (S2S) model coupled with VOF.

Findings
Numerical results are compared with the measures obtained on the prototype of the process. The results are in good agreement but the model needs to be improved to consider the varying viscosity of the glass.

Originality/value
The usage of a S2S radiation model coupled to the VOF model is not common for studies of materials melted by electromagnetic induction. This paper demonstrates the feasibility of this approach.
Good times and bad: responsibility in brand alliances
Authors: Newmeyer Casey E. , Ruth Julie A. 
Published: February 2020

Purpose
Marketing managers have strategic choices when forming brand alliances. One such choice is integration, defined as the extent to which the offering is a fusion in the form and function of the partner brands. The paper aims to investigate how integration affects consumer attribution of responsibility to brand alliance partners.

Design/methodology/approach
This paper builds on the previous study on brand alliances and attribution theory. Multiple experiments are used to test three hypotheses.

Findings
This research shows that consumers are sensitive to the level of alliance integration, which, in turn, affects attributions of responsibility for the joint offering. Consistent with attribution theory, results show that responsibility for each brand varies systematically by integration and lead brand status vis-à-vis the alliance: while consumers perceive both brands as equally responsible for higher integration brand alliances, responsibility attributions diverge in lower integration alliances based on whether the brand is the alliance host. This pattern also holds for product-harm events.

Research limitations/implications
It is important to explore brand alliance characteristics and to date, the level of integration between the partners has not been considered from a consumer standpoint. Consumers are sensitive to the level of partner brand integration and this perception influences perceptions of responsibility.

Practical implications
Managers should be aware that the level of brand alliance integration and lead brand status lead to different attributions of responsibility, which is strategically important, as brands seek to take credit in positive contexts and avoid blame for negative events.

Originality/value
This paper explores brand alliances via the level of integration and leads brand status, which are key determinants of consumer attributions of responsibility.
Mentee characteristics in inter-organizational mentoring for managers: a hybrid Delphi survey
Authors: Gisbert-Trejo Nuria , Albizu Eneka , Landeta Jon , Fernández-Ferrín Pilar 
Published: February 2020

PurposeInter-organizational mentoring (IOM) is a human resource development tool that is used when the mentor and mentee belong to different organizations. As mentees are the focus of the IOM process, the success of this type of program is highly reliant on their characteristics. Therefore, the purpose of this paper was to derive the most desirable characteristics for mentees in IOM.Design/methodology/approachAn intensive review of the literature on mentoring for managers and business professionals was carried out to identify mentee characteristics. These characteristics were then ranked for their importance to IOM using the Hybrid Delphi method (with 130 informants taking part in a Delphi survey and 19 expert IOM practitioners taking part in Focus Group and Nominal Group Technique sessions). An exploratory factor analysis identified the three main underlying factors behind the listed mentee characteristics.FindingsIn total, 17 relevant mentee characteristics were identified and ranked and then synthesized into three essential factors for the mentee. The results were discussed in the light of existing studies.Originality/valueThe mentee characteristics and factors identified in this study will be of great practical value to coordinators of IOM programs. Also, the review of the literature and the obtained results will help other researchers who wish to expand on this topic.
Residualisation in supported housing: an organisational case study
Authors: Hobson Jonathan , Lynch Kenneth , Lodge Alex 
Published: February 2020

PurposeThe purpose of this paper is to examine how residualisation is experienced across a supported housing provider in an English county. The analysis is in three parts: firstly, it focuses on organisational provision, including impacts of change on decisions on market entry and exit; secondly, it reviews evidence on service provision and the adaptations services are making to reflect the changing pressures of the sector; finally, it considers the impacts on service delivery and the experiences of those that rely on the provision.Design/methodology/approachThe analysis uses interview data across the organisation, together with material from the UK Government department consultation (2017) and a UK Parliamentary Select Committee inquiry (2017) to examine the impacts across the different tiers of service, including the day-to-day experience of residualised services for those that deliver and receive that support.FindingsThe paper concludes that residualisation is a direct outcome of the neoliberalisation of welfare states, introducing limits to state involvement and funding, a greater emphasis on quasi-market involvement in the sector and a shifting of responsibility from government to individuals.Research limitations/implicationsIt not only demonstrates the impacts of reducing state support on the supported housing sector but also emphasises the importance of residualisation as a conceptual framework applicable to the wider implications of austerity and neoliberal ideology.Practical implicationsThis paper demonstrates the way that the burden of responsibility is being shifted away from the public provision of support and onto the individuals. This can be problematic for the individuals who are vulnerable as a result of their economic medical or social circumstances.Social implicationsThe retreat of the state from supported housing is both a political change and an austerity-led change. This article provides insight from a single-supported housing provider. In so doing, it illustrates the pressure such an organisation is under.Originality/valueThis paper provides a unique insight from the perspective of all levels of a supported housing service provider, combined with the analysis of government consultation and parliamentary inquiry.
Toward sustainable development in post-flood relocation of rural settlements in Iran
Authors: Garakani Seyed Amirhossein , Lak Azadeh , Niyasati Masoomeh 
Published: February 2020

Purpose
Man has always faced natural hazards and thus attempted to reduce their financial and loss-of-life damages. Assuring sustainable development in the post-disaster reconstruction of areas requires predictive measurements (i.e. vulnerability assessment). This study aims to assess the outcomes of relocating villages after the 2005 flood in the east of Golestan Province in Iran through sustainable development.

Design/methodology/approach
This study is an applied research combining qualitative content analysis and quantitative cross-sectional surveys. The statistical population comprises the inhabitants of Faraghi New Town (formed by aggregating 11 villages) and the villagers returning to their former rural settlement. The independent samples t-test was used to compare the outcomes of reconstruction for the samples. Data were collected using a questionnaire and in-depth interviews with the residents. The gathered data were analyzed by content analysis.

Findings
The results indicate that building new settlements – while reducing physical vulnerability – cannot be classified as a step toward sustainable development in economic and social aspects because the increasing trend of migration to urban areas, return to former villages, tribal disparities, reduced production, increased bank debts and increased urban insecurity are among the primary adverse social and economic consequences of rural relocations. This finding helps to assist planners and post-disaster designers to reconstruct more sustainable societies.

Originality/value
This study tries to investigate the effects of post-disaster reconstruction in rural settlement in Iran through sustainable development aspects for the first time. It would benefit for policymaking and urban planners and designers to make more resilient societies after disasters.