bluuebunny/crossref_metadata_2025_split huggingface dataset:
The therapeutic use of 177 Lu-PSMA-617 radioligand therapy in prostate cancer treatment: a review of literature and ongoing trials
Authors: Konopnicki Alexander , Zaliznyak Michael , Roy Mathews , Jana Bagi 
Published: December 2024

AbstractRadioligand therapy is a targeted cancer treatment modality in which radioisotopes are utilized in the delivery of radiation at targeted cancer cells, with the goal of sparing normal cells. Prostate cancer is a well-known radiosensitive disease, historically treated with radioisotopes such as Strontium-89, Samarium-153, and Radium-223 for palliation of bone metastases. Recently, prostate specific membrane antigen (PSMA) has recently been employed as a radioligand target due to its unique properties of high expression on the surface of prostate cancer cells, limited expression in normal tissue, function as an internalizing cell surface receptor, and increased expression with androgen deprivation therapy. In 2015, 177Lu-PSMA-617 was first introduced as a promising treatment option for castration-resistant prostate cancer, and 7 years later the results of the phase III VISION trial led to 177Lu-PSMA-617 gaining FDA approval for the treatment of progressive castration-resistant prostate cancer. These results in combination with the inherent properties of 177Lu-PSMA-617 have led to its current exploration as a promising treatment modality beyond progressive metastatic castration-resistant prostate cancer, and into the earlier phases of prostate cancer. This review paper aims to highlight the key phase III randomized controlled trials related to 177Lu-PSMA-617 in all stages of prostate cancer, as well as bring attention to ongoing, earlier phase I/II trials incorporating 177Lu-PSMA-617.
A scientometric analysis on DFIG-based wind energy conversion system research trends
Authors: Thota Kalyaani , Velpula Srikanth , Basetti Vedik 
Published: December 2024

AbstractThis paper aims to provide a comprehensive summary of the current research on the global wind energy systems, in particular to Wind Energy Conversion Systems (WECS) with Doubly Fed Induction Generator (DFIG). The analysis is based on the Scopus database from the year 2001 to 2024 and uses multiple methodologies for analysis. During this period, 3,196 documented research papers related to DFIG-based WECS systems were identified. Only one paper was published in 2002, while 324 papers were published in 2018. Among the 22 countries contributing to this field, China, India, and Morocco led with 340, 317, and 131 articles, respectively. However, India demonstrated the best quality of research, with only 9% of its 317 papers classified as low quality, while 97.2% of these papers were considered high quality. Team efforts are prevalent, accounting for 79.32% of the work. The most frequently used journals for publication are the Journal of Renewable Energy with 83 articles, IEEE Transactions on Industry Applications with 52 articles, and the International Journal of Electrical Power and Energy Systems with 50 articles. English was the most commonly used language, reported in 97% of the papers. As a result, this research points out new directions and stimulates further investigations into wind energy research analysis.
The future of artificial intelligence: evaluating ChatGPT's performance in X sentiment prediction
Authors: Malas Laila , Shawaqfeh Ahmad , Abushakra Ahmad 
Published: December 2024

AbstractTechnological advancements have significantly progressed from the inception of computers and the internet to the rise of artificial intelligence (AI), profoundly impacting various sectors such as business, education, and healthcare. Among these advancements, ChatGPT has emerged as a prominent conversational AI tool, facilitating tasks such as sentiment prediction and sector-specific decision-making. This study aims to evaluate ChatGPT's performance in analyzing public sentiment using data from X (formerly Twitter) and to propose an ethical framework for its sector-specific applications. By combining the BERT transformer model with BiLSTM, Random Forest, and K-Nearest Neighbor algorithms, the study achieves a hybrid approach to sentiment prediction, demonstrating superior performance with an accuracy of 86.7%. Furthermore, the study explores ethical considerations, such as fairness, accountability, and transparency, to address ChatGPT's adoption across industries. The findings offer insights into both the technical and ethical dimensions of ChatGPT’s integration into business, education, and healthcare sectors, emphasizing its potential for sustainable and responsible use.
Structure of tubular halloysite-(10 Å) and its transition to halloysite-(7 Å) by infrared spectroscopy and X-ray diffraction
Authors: Siranidi Eirini , Hillier Stephen , Chryssikos Georgios D. 
Published: December 2024

Abstract
Halloysite nanotubes (often abbreviated as HNTs) are technologically important owing to their unique structural and morphological features. Some of these features pre-exist in the naturally hydrated halloysite-(10 Å) parent clay mineral; others may develop during its dehydration towards halloysite-(7 Å). This is the first infrared spectroscopic study of the transition to halloysite-(7 Å), which, in combination with X-ray diffraction (XRD), aimed at advancing the structural description of the process. Three cylindrical and two polygonal halloysite-(10 Å) samples, in both their H- and D-forms, were measured by attenuated total reflectance (ATR), non-invasively and in situ, following step-wise equilibration from 70% relative humidity (RH) to <10% RH and back to 70% RH at ambient temperature. This approach allowed for recording the spectrum of the dehydrating (but not rehydrating) interlayer in the νO–D range, without interference from the inner νOH groups, or from the inner-surface νOH of anhydrous interlayers already present in the parent material. Besides the well-known ‘hole’ H2O species, a new type of H2O-decorated defect was detected at frequencies normally dominated by the inner νOH. This defect is linked to the microenvironment created by the detachment between layer packets and forming ‘crevices’ or ‘slits’ upon dehydration. In addition, the study of the νSi–O spectrum demonstrated that the dehydration of halloysite-(10 Å) leads to the parallel formation of localized, ordered, kaolinite-like domains co-existing with regions of accumulated disorder. The as-produced halloysite-(7 Å) had a non-ideal, open structure that resisted rehydration because the kaolinite-like domains do not rehydrate and act as permanent cross-links.
‘Hell? Yes!’ Moorean reasons to reject three objections to the possibility of damnation
Authors: Rooney James Dominic 
Published: December 2024

Abstract
Objections to the orthodox doctrine of an eternal hell often rely on arguments that it cannot be a person’s own fault that she ends up in hell. The article summarizes and addresses three significant arguments which aim to show that it could not be any individual’s fault that they end up in hell. I respond to these objections by showing that those who affirm a classical picture of sin have Moorean reasons to reject these objections. That classical perspective holds that all (serious) sin involves choosing eternal destiny apart from God and that no sin could possibly be caused by God. Consequently, it is necessary for ending up in hell that someone commit a serious sin, and it is sufficient for ending up damned that one persists forever in sin. Since the objections conflict with Moorean commitments central to the classical perspective, those who hold to such a classical perspective on sin would have good reason to reject all these arguments, which involve assumptions that would entail that such a perspective is false.
Road toward institutionalizing health technology assessment in the Emirate of Abu Dhabi: The role of evidence-informed deliberative processes
Authors: Bijlmakers Leon , Egeli Pinar , Al Saeedi Amna Ibrahim , Sadoon Bakr , Richter Dirk , Oortwijn Wija 
Published: December 2024

Abstract

Objective
This paper reports on the process used to embark on one of the core strategies of Abu Dhabi’s Department of Health, which was to develop a roadmap for HTA implementation and institutionalization, based on the aspirations and needs of local stakeholders and making use of the evidence-informed deliberative processes framework. The paper also highlights the main features of the road map that may be expected to address some of the current challenges.

Methods
A series of activities were undertaken that informed the subsequent development of the roadmap. They comprised a situation analysis using a combination of desk research and semistructured (group) interviews with 45 stakeholders. The findings were discussed in two workshops; face-to-face with nonindustry stakeholders from Abu Dhabi, and online with industry representatives.

Results
Guided by the EDP framework, the roadmap provides instructions how to organize stakeholder involvement, how to identify and operationalize decision criteria, and how to ensure that the decision-making process is transparent. Specific guidance is given on establishing an HTA structure with an appropriate policy framework, the formulation of an HTA program, a communication strategy, as well as building and leveraging HTA expertise.

Conclusion
Broad stakeholder consultation has been instrumental toward the establishment of a comprehensive HTA framework in Abu Dhabi, and the development of a road map. The interest raised during stakeholder consultations and the commitments made hold promise for the adoption and establishment of EDP principles to support HTA in Abu Dhabi that have potential to contribute to a sustainable high-quality healthcare system.
Psilocybin increases emotional empathy in patients with major depression
Authors: Jungwirth J. , von Rotz R. , Dziobek I. , Vollenweider F. X. , Preller K. H. 
Published: December 2024

AbstractEmpathy plays a crucial role in interpersonal relationships and mental health. It is decreased in a variety of psychiatric disorders including major depression. Psilocybin, a promising candidate for treating depression, has been shown to acutely increase emotional empathy in healthy volunteers. However, no study has investigated this effect and its relevance for symptom improvement in a clinical population. This study examines the enduring effects of psilocybin-assisted therapy on empathy in depressed patients using a randomized, placebo-controlled design. Fifty-one depressed patients were randomly assigned to receive a single dose of psilocybin (0215 mg/kg body weight) or a placebo embedded in a 4-week psychological support intervention. Empathy was measured using the Multifaceted Empathy Test at baseline and 2 days, 1 week, and 2 weeks after substance administration. Changes in empathy were compared between treatment conditions. Patients who received psilocybin showed significant improvements in explicit emotional empathy driven by an increase in empathy towards positive stimuli compared to the placebo group for at least two weeks. This study highlights the potential of psychedelics to enhance social cognition in individuals living with depression and contributes to a better understanding of the psychological mechanisms of action of psychedelics. Further studies are necessary to investigate the interaction between social cognition and clinical efficacy.The trial is registered on clinicaltrials.gov (Identifier: NCT03715127) and KOFAM (Identifier: SNCTP000003139).
The scramblases VMP1 and TMEM41B are required for primitive endoderm specification by targeting WNT signaling
Authors: Holzner Markus , Sonicki Tea , Hunn Hugo , Uliana Federico , Jiang Weijun , Gade Vamshidhar R. , Weis Karsten , Wutz Anton , Di Minin Giulio 
Published: December 2024

AbstractThe ER-resident proteins VMP1 and TMEM41B share a conserved DedA domain, which confers lipid scramblase activity. Loss of either gene results in embryonic lethality in mice and defects in autophagy and lipid droplet metabolism. To investigate their role in pluripotency and lineage specification, we generated Vmp1 and Tmem41b mutations in mouse embryonic stem cells (ESCs). We observed that ESCs carrying mutations in Vmp1 and Tmem41b show robust self-renewal and an unperturbed pluripotent expression profile but accumulate LC3-positive autophagosomes and lipid droplets consistent with defects in autophagy and lipid metabolism. ESCs carrying combined mutations in Vmp1 and Tmem41b can differentiate into a wide range of embryonic cell types. However, differentiation into primitive endoderm-like cells in culture is impaired, and the establishment of extra-embryonic endoderm stem (XEN) cells is delayed. Mechanistically, we show the deregulation of genes that are associated with WNT signaling. This is further confirmed by cell surface proteome profiling, which identified a significant reduction of the WNT-receptor FZD2 at the plasma membrane in Vmp1 and Tmem41b double mutant ESCs. Importantly, we show that transgenic expression of Fzd2 rescues XEN differentiation. Our findings identify the role of the lipid scramblases VMP1 and TMEM41B in WNT signaling during extra-embryonic endoderm development and characterize their distinct and overlapping functions.
AAV library screening identifies novel vector for efficient transduction of human aorta
Authors: Schröder Lena C. , Hüttermann Leonard , Kliesow Remes Anca , Voran Jakob C. , Hille Susanne , Sommer Wiebke , Lutter Georg , Warnecke Gregor , Frank Derk , Schade Dennis , Müller Oliver J. 
Published: December 2024

AbstractTargeted gene delivery to vascular smooth muscle cells (VSMCs) could prevent or improve a variety of diseases affecting the vasculature and particularly the aorta. Thus, we aimed to develop a delivery vector that efficiently targets VSMCs. We selected engineered adeno-associated virus (AAV) capsids from a random AAV capsid library and tested the top enriched motifs in parallel screening through individual barcoding. This approach allowed us to distinguish capsids that only transduce cells based on genomic DNA (gDNA) from those also mediating transgene expression based on transcribed cDNA reads. After three rounds of selection on primary murine VSMCs (mVSMCs), we identified a novel targeting motif (RFTEKPA) that significantly improved transduction and gene expression efficiency over AAV9-wild type (WT) and increased expression in mVSMCs by 70% compared to the previously identified SLRSPPS peptide. Further analysis showed that the novel motif also improved expression in human aortic smooth muscle cells (HAoSMCs) and human aortic tissue ex vivo up to threefold compared to SLRSPPS and approximately 70-fold to AAV9-WT. This high cross-species transduction efficiency makes the novel capsid motif a potential candidate for future clinical application in vascular diseases.
Record-low Antarctic sea ice in 2023 increased ocean heat loss and storms
Authors: Josey Simon A. , Meijers Andrew J. S. , Blaker Adam T. , Grist Jeremy P. , Mecking Jenny , Ayres Holly C. 
Published: December 2024

AbstractRecent Antarctic sea-ice decline is a substantial source of concern, notably the record low in 2023 (ref. 1). Progress has been made towards establishing the causes of ice loss1–5 but uncertainty remains about its consequences for ocean–atmosphere interaction. Resolution of this uncertainty is important as ice decline can substantially alter surface heat loss and thus the ocean and atmosphere6. Here we show that the strongest winter 2023 ice-retraction regions provide an important new source of turbulent ocean heat loss to the atmosphere in wintertime. Ice concentration in these regions (located primarily in the Weddell, Bellingshausen and Ross seas) is reduced by up to 80% and is accompanied by an unprecedented doubling of mid-winter ocean heat loss. Also, there is a phase shift in the time of peak heat loss from late April to mid-June, with weaker than normal heat loss in austral autumn. The winter surface-heat-loss intensification is accompanied by substantial changes on both sides of the ocean–atmosphere interface. These include increases in atmospheric-storm frequency and surface-heat-loss-driven dense water formation, although the implications of the densification for broader processes such as Antarctic bottom water formation remain unclear. Our results reveal that the 2023 Antarctic sea-ice loss has substantially modified air–sea interaction in the Southern Ocean and motivate in-depth analysis of the wider climate-system impacts.
Chain splitting of insulin: an underlying mechanism of insulin resistance?
Authors: Cramer Christian N. , Hubálek František , Brand Christian Lehn , Helleberg Hans , Kurtzhals Peter , Sturis Jeppe 
Published: December 2024

AbstractDespite decades of intense research, the mechanisms underlying insulin resistance are still poorly understood. What if one of the major causes of insulin resistance is not related to defects in the target tissues and/or insulin receptor signaling, but rather to a reduced survival of endogenously secreted insulin on its way to activating the receptor on the cell surface of the target tissues? Here, we present data and lay out arguments in support of this novel hypothesis, which is fundamentally different from the common view that insulin resistance is caused by the body’s cells becoming less sensitive to insulin.
Exposure to Psychotropic Drugs and Colorectal Cancer Risk in Patients
with Affective Disorder: A Nested Case-Control Study
Authors: Hsu Tien-Wei , Tsai Shih-Jen , Chen Tzeng-Ji , Chen Mu-Hong , Liang Chih-Sung 
Published: December 2024

Abstract
Background This study aimed to assess the association between the risk of
colorectal cancer (CRC) and exposure to mood stabilizers, antidepressants, and
antipsychotics in patients with affective disorders.
Methods This nested case-control study used data from the National Health
Insurance Database of Taiwan collected between 2001 and 2011. All participants
in this study had affective disorders. Then, 1209 patients with CRC and 1:10
matched controls were identified based on their demographic and clinical
characteristics. A logistic regression model adjusted for demographic and
clinical characteristics was used to determine the risk of developing CRC after
exposure to psychotropic drugs.
Results Among patients with affective disorders, exposure to mood
stabilizers (reported as odds ratio; 95% confidence interval; 0.75; 0.57–0.98),
antidepressants (0.83; 0.70–0.97), second-generation antipsychotics (0.67;
0.52–0.86), and first-generation antipsychotics (0.65; 0.52–0.81) were
associated with a reduced risk of CRC compared to patients who were not exposed.
When considering specific drugs, carbamazepine (0.34; 0.12–0.95), valproic acid
(0.66; 0.46–0.95), gabapentin (0.44; 0.20–0.99), fluoxetine (0.82; 0.68–0.99),
paroxetine (0.63; 0.45–0.87), and venlafaxine (0.72; 0.55–0.95) were associated
with a lower risk of CRC.
Conclusion Exposure to psychotropic drugs in patients with affective
disorders is associated with a lower risk of CRC compared to those who were not
exposed. Although the causal relationship between psychotropic drug exposure and
reduced risk of CRC could not be inferred directly, these findings may help
clinicians and patients in clinical decision-making.
Cu-Nanoclusters as Emerging Catalyst in Organic Synthesis
Authors: Sahoo Basudev , Negishi Yuichi , Pal Amit , Biswas Sourav 
Published: December 2024

AbstractIn recent decades, nanocluster research has rapidly advanced. Though Cu nanoclusters are relatively new to the field, their use in chemical catalysis has expanded the potential applications of these materials. The reactivity of Cu nanoclusters is primarily determined by their precisely controlled structural architecture and surface-to-volume ratio. However, these factors are prone to change, significantly impacting their catalytic properties. Therefore, a comprehensive understanding of these parameters is crucial to guide future research efforts and develop new Cu nanoclusters with broader applications.1	Introduction2	Click Reaction3	Carbamate Synthesis4	Ullmann (C–N) Coupling5	Indolizine Synthesis6	Hydrogenation Reaction7	Sonogashira Reaction8	Hydroboration Reaction9	Decarboxylative Oxidation of Carboxylic Acids10	Conclusion
A digital servo for ultra-stable laser frequency stabilization
Authors: Liu Zhengtao , Wang Yu , Ji Wenchao , Hu Yi , Cui Xingyang , Jiang Xiao , Feng Changqing , Liu Shubin 
Published: December 2024

We present a fully digital servo optimized for ultra-stable laser frequency stabilization. Experiments such as optical clock experiments can achieve high laser frequency stability, imposing high bandwidth, high precision, and low noise requirements on servo systems. The laser system utilizes the Pound–Drever–Hall method, employing an ultra-stable cavity to generate an error signal for servo input. The input is separated into two independent channels, with one channel featuring high feedback bandwidth and the other channel featuring high gain in the low-frequency domain. The process is fully digitized using field-programmable gate arrays with custom-made infinite impulse response filters and proportional-integral-derivative algorithms. Thanks to the low latency of 120.5 ns and low input noise of 3.22 × 10−12 V2/Hz@1 Hz, our digital servo can easily lock an external-cavity diode laser to a typical ultra-low expansion ultra-stable cavity. The laser system has a fractional frequency stability of 10−16@1s, with the servo electrical noise contributing only 5.54 × 10−18@1s.
Understanding crystallization and amorphization in liquid Ti cooled at different rates: A molecular dynamics simulation study
Authors: Hazarika Manash Protim , Bordoloi Puja , Tripathi Ajay , Chakraborty Somendra Nath 
Published: December 2024

Crystallization and amorphization are important processes and different cooling rates cause these transitions. Obtaining pure metals from their molten state is a challenge unless these two are well understood. Here we study both these transitions in liquid Ti using molecular dynamics simulations wherein Ti is modeled with embedded atom potential. At 1 bar, Ti crystal is melted and then cooled from 2200 to 300 K with cooling rates of 0.1, 1, and 10 K/ps. When cooled at 0.1 and 1 K/ps, molten Ti crystallizes to bcc phase between 1100 and 1000 K, and when cooled at 10 K/ps, it amorphizes between these temperatures. From radial distribution functions and Voronoi tessellation, we observe that liquid to bcc transition takes place through short range distorted hcp/bcc-like structures already present in it. Relaxation dynamics is studied using velocity-autocorrelation functions (VACFs), intermediate scattering function, and dynamic structure factor. For all cooling rates, relaxations in VACFs increase with cooling. However, correlations in them are stronger when the system is cooled at 10 K/ps. Relaxation times decrease and increase between 1100 and 1000 K for crystallization and amorphization, respectively, thereafter they increase again with further cooling. The dynamic structure factor shows stronger damping in thermal diffusive motion when systems are cooled at 0.1 and 1 K/ps and vibration peaks shift to higher frequencies when crystallization take place. Our findings support Binder’s [K. Binder, Proc. Natl. Acad. Sci. U. S. A. 111, 9374 (2014)] argument that if we cool the system faster than the minimum time needed for the liquid to relax, it will amorphize. This also prevents the growth of pre-ordered domains in it to establish long-range order.