bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alpha 1-antichymotrypsin contributes to stem cell characteristics and enhances tumorigenicity of glioblastoma
Authors: Lara-Velazquez Montserrat , Zarco Natanael , Carrano Anna , Phillipps Jordan , Norton Emily S , Schiapparelli Paula , Al-kharboosh Rawan , Rincon-Torroella Jordina , Jeanneret Stephanie , Corona Teresa , Segovia Jose , Jentoft Mark E , Chaichana Kaisorn L , Asmann Yan W , Quiñones-Hinojosa Alfredo , Guerrero-Cazares Hugo 
Published: November 2020

Abstract

Background
Glioblastomas (GBMs) are the main primary brain tumors in adults with almost 100% recurrence rate. Patients with lateral ventricle proximal GBMs (LV-GBMs) exhibit worse survival compared to distal locations for unknown reasons. One hypothesis is the proximity of these tumors to the cerebrospinal fluid (CSF) and its chemical cues that can regulate cellular phenotype. We therefore investigated the role of CSF on GBM gene expression and the role of a CSF-induced gene, SERPINA3, in GBM malignancy in vitro and in vivo.

Methods
We utilized human CSF and GBM brain tumor-initiating cells (BTICs). We determined the impact of SERPINA3 expression in glioma patients using The Cancer Genome Atlas (TCGA) database. SERPINA3 expression changes were evaluated at mRNA and protein levels. The effects of knockdown (KD) and overexpression (OE) of SERPINA3 on cell migration, viability and cell proliferation were evaluated. Stem cell characteristics on KD cells were evaluated by differentiation and colony formation experiments. Tumor growth was studied by intracranial and flank injections.

Results
GBM-CSF increased BTIC migration accompanied by upregulation of the SERPINA3 gene. In patient samples and TCGA data, we observed SERPINA3 to correlate directly with brain tumor grade and indirectly with GBM patient survival. SERPINA3 KD induced a decrease in cell proliferation, migration, invasion, and stem cell characteristics, while SERPINA3 OE increased cell migration. In vivo, SERPINA3 KD BTICs showed increased survival in a murine model.

Conclusions
SERPINA3 plays a key role in GBM malignancy and its inhibition results in a better outcome using GBM preclinical models.
Neuropathology of Pituitary Adenomas and Sellar Lesions
Authors: Kobalka Peter J , Huntoon Kristin , Becker Aline P 
Published: November 2020

Abstract
The pituitary gland is the site of numerous neoplastic and inflammatory processes. The overwhelmingly most frequent tumors arise from cells of the anterior lobe, the pituitary neuroendocrine tumors (PitNETs). Immunohistochemistry assay staining for pituitary hormones is the core tool for classifying PitNETs, resulting in the diagnosis of somatotroph PitNETs, lactotroph PitNETs, and so on. For cases showing no hormonal expression, the updated WHO classification system now considers the assessment of several transcription factors: PIT-1 (pituitary-specific POU-class homeodomain transcription factor); T-PIT (T-box family member TBX19); and SF-1 (steroidogenic factor regulating gonadotroph cell differentiation) before rendering a diagnosis of null cell adenoma. Other tumors and disease processes of this site often mimic PitNETs radiographically and sometimes even clinically (ie, compression of the optic chiasm). These potpourri of processes include germ cell neoplasms (especially germinomas), tumors that originate from Rathke's pouch (craniopharyngiomas, Rathke's cleft cyst), tumors that originate from the posterior lobe of the pituitary (pituicytoma, spindle cell oncocytoma, granular cell tumor), and tumors that originate from the meninges (especially meningiomas). In addition to neoplasms, several described inflammatory and related conditions exist that need to be distinguished from PitNETs. These include lymphocytic hypophysitis and Langerhans cell histiocytosis, a neoplastic disorder of histiocytes. In this review, we aim to briefly describe the main pituitary and sellar lesions, with emphasis on the most common tumors, the PitNETs.
Understanding collaborative interactions in relation to research impact in social sciences and humanities: A meta-ethnography
Authors: Dewaele Alexis , Vandael Kristof , Meysman Stefan , Buysse Ann 
Published: November 2020

Abstract
The number and type of collaborations between researchers and stakeholders has increased significantly. This responds to the demand from policymakers, funders, and citizens that researchers should help to tackle important social issues (e.g. climate change, healthy aging). However, there is little knowledge about how collaboration processes are experienced, how we can theoretically conceptualize them, and how in this way we can develop efficient collaboration methods that contribute to solving urgent societal problems. In this meta-ethnography, we gathered relevant knowledge from carefully selected qualitative studies. A title/abstract analysis of 3422 articles from Web of Science and ProQuest led to the interpretative analysis of qualitative data from eight publications. The results of this study show that despite the need for a better understanding of complex collaborative interactions, the differences (or asymmetry) between organizations to which various partners belong hinder efficient collaboration. Bridging figures (brokers) can play an essential role if they succeed in drawing diverse stakeholders out of their organizational context into a new dimension that allows creativity and mutual understanding, but that also allows conflict and distortion. In ideal circumstances, this leads to a quasi-automatic transfer of knowledge between partners that takes place naturally and in both directions (knowledge diffusion).
DEVELOPMENTS IN THE USE OF THERMOLUMINESCENCE AND OPTICALLY STIMULATED LUMINESCENCE FROM MOBILE PHONES IN EMERGENCY DOSIMETRY
Authors: McKeever S W S , Sholom S , Chandler J R 
Published: November 2020

Abstract
Proposed physical dosimetry methods for emergency dosimetry in radiological, mass-casualty incidents include both thermoluminescence (TL) and optically stimulated luminescence (OSL). Potential materials that could feasibly be used for TL and OSL dosimetry include clothing, shoes and personal accessories. However, the most popular target of study has been personal electronics, especially different components from smartphones. Smartphones have been a focus because they are widely available and, in principle, may be viewed as surrogates for commercial TL or OSL dosimeters. The components of smartphones that have been studied include surface mount devices (such as resistors, capacitors and inductors) and glass materials, including front protective glass, display glass and (with more modern devices) back protective glass. This paper reviews the most recent developments in the use of TL and OSL with these materials and guides the way to future, and urgently needed, research.
The Under-Utilization of Women’s Talent: Academic Achievement and Future Leadership Positions
Authors: Qian Yue , Yavorsky Jill E 
Published: November 2020

Abstract
Despite high labor force participation, women remain underrepresented in leadership at every level. In this study, we examine whether women and men who show early academic achievement during their adolescence—and arguably signs of future leadership potential—have similar or different pathways to later leadership positions in the workplace. We also examine how leadership patterns by gender and early academic achievement differ according to parenthood status. Using data from the National Longitudinal Survey of Youth 1979, we find that overall, men supervise more people than women at work during their early-to-mid careers, regardless of their grade point averages (GPAs) in high school. In addition, among men and women who are parents, early academic achievement is much more strongly associated with future leadership roles for fathers than it is for mothers. Such patterns exacerbate gender gaps in leadership among parents who were top achievers in high school. Indeed, among those who had earned a 4.0 GPA in high school, fathers manage over four times the number of supervisees as mothers do (nineteen vs. four supervisees). Additional analyses focusing on parents suggest that gender leadership gaps by GPA are not attributable to different propensities for taking on leadership roles between the genders but are in part explained by unequal returns to educational attainment and differences in employment-related characteristics by gender. Overall, our results reveal that suppressed leadership prospects apply to even women who show the most promise early-on and highlight the vast under-utilization of women’s (in particular mothers’) talent for organizational leadership.
Rheumatology in the era of precision medicine: synovial tissue molecular patterns and treatment response in rheumatoid arthritis
Authors: Lakhanpal Amit , Smith Melanie H. , Donlin Laura T. 
Published: November 2020

Purpose of review
A critical unmet need in rheumatoid arthritis (RA) is the identification of biomarkers that predict which of the available medications will be most effective for an individual in order to lower disease activity sooner than is afforded by the current treat-to-target approach. Here we will discuss recent reports examining the potential for synovial tissue molecular, cellular, and spatial profiling in defining objective measures of treatment response and therein developing personalized medicine for RA.

Recent findings
Recent high-dimensional molecular profiling of RA synovium has provided unprecedented resolution of the cell types and pathways in tissues affected by rheumatic diseases. Heightened attention to tissue architecture is also emerging as a means to classify individual disease variation that may allow patients to be further stratified by therapeutic response. Although this wealth of data may have already pinpointed promising biomarkers, additional studies, likely including tissue-based functional drug response assays, will be required to demonstrate how the complex tissue environment responds.

Summary
Molecular, cellular, and more recently spatial profiling of the RA synovium are uncovering fundamental features of the disease. Current investigations are examining whether this information will provide meaningful biomarkers for individualized medicine in RA.
POTENTIAL NEW-ONSET CLINICALLY DETECTABLE PENTOSAN POLYSULFATE MACULOPATHY YEARS AFTER DRUG CESSATION
Authors: Barnett Joshua M. , Jain Nieraj 
Published: November 2020

Purpose:
To describe a potential case of pentosan polysulfate maculopathy that seemed to manifest nearly 3 years after drug cessation.

Methods:
Complete ophthalmic examination, including multimodal fundus imaging, electroretinography, automated perimetry, and molecular testing, was performed.

Results:
A 44-year-old woman with a 435 g cumulative exposure to pentosan polysulfate sodium presented 38 months after drug cessation with 6 months of worsening metamorphopsia and prolonged dark adaptation. Fundus examination and multimodal fundus imaging demonstrated characteristic features of pentosan polysulfate maculopathy, and molecular testing was unremarkable. By contrast, color fundus photographs of the same patient acquired at an outside facility 25 months before did not display features consistent with pentosan polysulfate sodium maculopathy.

Conclusion:
This case suggests that new-onset clinically detectable pentosan polysulfate maculopathy may develop years after drug cessation. If corroborated, this finding has important ramifications for pentosan polysulfate sodium dosing and surveillance guidelines.
CAVITARY CHOROIDAL NEVUS: A CASE REPORT
Authors: Preziosa Chiara , Kashyap Bibhuti P. , Staurenghi Giovanni , Pellegrini Marco 
Published: November 2020

Purpose:
To describe a case of choroidal nevus with intralesional cavitations detected with enhanced depth imaging optical coherence tomography and to show its changes during an 8-year follow-up.

Methods:
A case report.

Results:
A 55-year-old male patient was found to have a pigmented lesion at the posterior pole of his right eye, just temporal to the fovea. A complete multiimaging examination was obtained and showed a lesion of about 4 mm of diameter with a small amount of subretinal fluid and chronic changes in the retina overlying the lesion. Based on clinical examination, a diagnosis of choroidal nevus was made, but interestingly the enhanced depth imaging optical coherence tomography revealed the presence of intralesional cavitations. Close follow-up with no intervention was planned, and over 8 years of observation, the lesion remained stable in size, with a gradual increase of the central necrosis.

Conclusion:
Benign pigmented choroidal lesions can show internal cavitations likely secondary to internal necrosis. This feature does not represent a sign of malignancy of the lesion. Enhanced depth imaging optical coherence tomography is a feasible imaging tool for the visualization of the internal cavitations and to follow their evolution over time.
The prevalence and incidence of community-acquired pressure injury
Authors: Chen Geng , Lin Lv , Yan-Lin Yang , Loretta Chung Yuet-Foon , Han Lin 
Published: November 2020

Abstract

Background:
Pressure injury (PI) is a serious problem in health care settings globally. It leads to tremendous burden both individuals and healthcare systems. Since 2008, hospital-acquired pressure injuries have been a major focus of nursing quality improvement programs within hospitals and are considered never events. However, insufficiency attention has been paid to community-acquired pressure injuries (CAPI) or pressure ulcers that occur at home or in nursing homes. The prevalence or incidence of community-acquired pressure injury has been reported but never been synthesized in a meta-analysis manner. To fill the gaps in the evidence matrix, the aims of this study are to estimate the prevalence of CAPI in the general population and to pool the overall incidence of CAPI in the general population.

Methods:
PubMed, Web of Science, EMBASE, CINHAL, the Cochrane Library, Chongqing VIP, and China National Knowledge Infrastructure were electronically searched to identify eligible studies updated to May 2020 to collect studies on the prevalence or incidence of community-acquired pressure injuries. Two reviewers independently will screen the literature, extracted data, and assess the risk of bias of included studies using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guideline. Meta-analyses of pooled weighted estimates will be calculated using random effect models with 95% CIs reported due to high heterogeneity.

Results:
Of the 5242 studies initially identified, of the 22 studies (total 479,761 participants) 17 reporting prevalence of community-acquired pressure injury and 5 reporting incidence were included. Other results of this study will be published in a peer-reviewed journal.

Conclusion:
This study will summarize the pooled estimate prevalence and incidence of community-acquired pressure injuries and the pooled estimate of frequencies of different anatomic sites.

Ethics and dissemination:
Ethics approval and patient consent are not required, because this study is a meta-analysis based on published studies.

INPLASY registration number:
INPLASY202080044
Fungal endocarditis with heart valve replacement and atrial fibrillation posing a treatment challenge
Authors: Zhu Xiaoxia , Cao Shugang , Xia Mingwu , Ding Chandong , Wang Rongfeng 
Published: November 2020

Abstract

Rationale:
Fungal endocarditis (FE) is a rare disease, in which antifungal treatment is necessary. When FE is complicated with prosthetic heart valve and/or atrial fibrillation, the coadministration of antifungal agents and warfarin is inevitable. We report a case of rheumatic heart disease with atrial fibrillation who developed FE following prosthetic heart valve replacement. The international normalized ratio (INR) increased significantly during the antifungal treatment with fluconazole. A discussion of the antifungal strategy in FE patients with prosthetic heart valves and/or atrial fibrillation and the interaction between antifungal agents and warfarin was performed.

Patient concerns:
A 54-year-old Chinese woman experienced intermittent fevers, aphemia, and weakness in her right extremities. Her temperature was 38.7°C, and there was atrial fibrillation with heart rate 110 times/min. Neurological examination revealed that she had drowsiness, Broca aphasia, right central facial paralysis, and hemiplegia (Medical Research Council scale, upper limb grade 0, lower limb grade II).

Diagnoses:
Multiple infarction on magnetic resonance imaging and the occlusion of left middle cerebral artery suggested the occurrence of cerebral embolism. The presence of Candida parapsilosis in the results of 4 blood cultures and the existence of valve vegetation in the reexamination of echocardiogram supported the diagnosis of FE.

Interventions:
The patient was given antifungal therapy with fluconazol. The INR increased dramatically on the 9th day of antifungal treatment, and subcutaneous bruising occurred at the intravenous infusion site. The antagonist of vitamin K1 was used and warfarin was reduced to a smaller dosage. The antifungal agent was replaced with caspofungin.

Outcomes:
Her speech improved significantly, and the muscle strength of her paralyzed side reached the Medical Research Council scale of grade IV+. She continued to receive caspofungin for antifungal treatment with relatively stable INR and waited for heart valve surgery.

Lessons:
The choice of antifungal agents is often a big challenge for FE patients, especially when they need warfarin for anticoagulation. It is better to administer a low dose of warfarin while carefully monitoring the INR or choose the antifungal drugs with little or no effect on warfarin.
Occult olfactory neuroblastoma presenting with multiple bone metastases: a case report
Authors: Zhou Qi , Li Zijian , Liu Bei , Zhao Long , Tian Baohong , Wang Lina , Xi Yaming 
Published: November 2020

Abstract

Rationable:
Olfactory neuroblastoma (ONB) is a rare malignant tumor of the nasal cavity, the primary local symptoms are usually inconspicuous. Patients are often admitted to various specialties based on different primary symptoms, which may result in delayed diagnosis and even a misdiagnosis.

Patient concerns:
Here we report a case of ONB that presented initially as multiple ostealgia without any local symptoms of the tumor and primarily misdiagnosed as multiple myeloma. The patient was a 47-year-old female with bone pain at multiple sites. The initial diagnosis was considered as multiple myeloma. However, the morphologic examination of bone marrow suggested that the tumor cells originated from the nervous tissues. After the positron emission computed tomography scan, the primary lesion in the nasal cavity was located, and a biopsy was performed.

Diagnosis:
The final diagnosis of ONB was confirmed by histopathological tests.

Interventions:
The patient was treated with metronomic chemotherapy.

Outcomes:
The symptoms of bone pain were significantly relieved 3 months later. The emission computed tomography scan of the whole body bones and the magnetic resonance imaging of the head showed that the tumor size did not change significantly and proved a progression-free of the disease.

Lessons:
It is a reasonable strategy to identify the original latent tumor by a prompt positron emission computed tomography scan when the primary diagnosis indicates a metastatic disease, especially for the occult malignancies like ONB.
A nomogram for estimating the probability of nonalcoholic fatty liver disease in a Chinese population
Authors: Xie Weining , Chen Shengxin 
Published: November 2020

Abstract
Studies have showed that dyslipidemia is closely related to nonalcoholic fatty liver disease (NAFLD). However, less attention has been paid to the relationship between early dyslipidemia and long-term risk of NAFLD. Therefore, we aimed to develop a simple-to-use nomogram to predict early dyslipidemia and long-term risk of NAFLD onset.
A retrospective cohort study including 3621 employees (including retirees) from 7 companies was conducted between 2012 and 2019. Anthropometric, potential laboratory parameters and abdominal ultrasound were performed at baseline and after a 5-year follow-up. Cox proportional hazards model was used to determine predictors for NAFLD onset. The effects of lipids, age, body mass index (BMI), and serum uric acid (UA) on NAFLD were evaluated with the use of Kaplan–Meier curves (log-rank test). A nomogram was developed based on the Cox proportional hazard model and a 2-piecewise linear regression model. The accuracy of model was evaluated according to the area under the receiver operating characteristic curves.
A total of 1545 subjects were included in the final analysis. The mean follow-up time was 52 ± 6.6 months. Of the total subjects, 77.61% were male and 22.39% were female. The mean age at the time of initial visit was 45.21 ± 11.20 years. Five hundred fifty-five subjects (35.92% of all subjects) were finally diagnosed with NAFLD. Variables in the nomogram included age, BMI, triglycerides, high-density lipoprotein, low-density lipoprotein, and UA. The accuracy of the nomogram for predicting 5-year cumulative occurrence of NAFLD was 0.8135 (95% confidence interval: 0.7921–0.8349), and the sensitivity and specificity were 0.8108 and 0.6960, respectively.
The combination of age, BMI, triglycerides, high-density lipoprotein, low-density lipoprotein, and UA translated into a nomogram can reliably estimate the incidence of NAFLD within 5 years. It may serve as a decision support tool to determine whether to intervene at an early stage.
Nebulized versus invasively delivered surfactant therapy for neonatal respiratory distress syndrome
Authors: Rong Hui , Bao Ying , Wen Zunjia , Chen Xiuli , Chen Cen , Li Fang 
Published: November 2020

Abstract

Background:
Pulmonary surfactant (PS) is commonly used for the treatment of neonatal respiratory distress syndrome (NRDS), several randomized controlled trials (RCTs) have evaluated the role of nebulized versus invasively delivered PS, yet the results remained inconsistent. Therefore, we aimed to conduct this meta-analysis to evaluate the effects and safety of nebulized versus invasively delivered PS in the treatment of NRDS.

Methods:
We searched PubMed et al databases from inception date to May 15, 2020 for RCTs that compared nebulized vs invasively delivered PS. Two authors independently screened the studies and extracted data from the published articles. Summary odd ratios (OR) or mean differences (MDs) with 95% confidence intervals (CIs) were calculated for each outcome by means of fixed- or random-effects model.

Results:
Two RCTs with a total of 95 preterm neonates were identified, with 48 neonates received PS nebulization and 47 neonates undergone invasive PS administration. There was no significant difference in the SpO2 level (MD = −0.44, 95% CI −6.01 to 5.12) and the A/APaO2 level (MD = 0.01, 95% CI −0.02 to 0.05) 1 hour after treatment among 2 groups. But the duration of mechanical ventilation in the nebulization groups was significantly less than that of invasive group (MD = −30.70, 95% CI −41.45 to 19.95).

Conclusions:
Given the limited evidences, the effects and safety of nebulized versus invasively delivered PS still need further verification.