bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeted Mass Spectrometry of a Clinically Relevant PSA Variant from Post‐DRE Urines for Quantitation and Genotype Determination
Authors: Otto Joseph J. , Correll Vanessa L. , Engstroem Hampus A. , Hitefield Naomi L. , Main Brian P. , Albracht Brenna , Johnson‐Pais Teresa , Yang Li Fang , Liss Michael , Boutros Paul C. , Kislinger Thomas , Leach Robin J. , Semmes Oliver J. , Nyalwidhe Julius O. 
Published: July 2020

PurposeThe rs17632542 single nucleotide polymorphism (SNP) results in lower serum prostate specific antigen (PSA) levels which may further mitigate against its clinical utility as a prostate cancer biomarker. Post‐digital rectal exam (post‐DRE) urine is a minimally invasive fluid that is currently utilized in prostate cancer diagnosis. To detect and quantitate the variant protein in urine.Experimental designFifty‐three post‐DRE urines from rs17632542 genotyped individuals processed and analyzed by liquid chromatography/mass spectrometry (LC‐MS) in a double‐blinded randomized study. The ability to distinguish between homozygous wild‐type, heterozygous, or homozygous variant is examined before unblinding.ResultsStable‐isotope labeled peptides are used in the detection and quantitation of three peptides of interest in each sample using parallel reaction monitoring (PRM). Using these data, groupings are predicted using hierarchical clustering in R. Accuracy of the predictions show 100% concordance across the 53 samples, including individuals homozygous and heterozygous for the SNP.Conclusions and clinical relevanceThe study demonstrates that MS based peptide variant quantitation in urine could be useful in determining patient genotype expression. This assay provides a tool to evaluate the utility of PSA variant (rs17632542) in parallel with current and forthcoming urine biomarker panels.
The endothelin receptor antagonist macitentan for the treatment of pulmonary arterial hypertension: A cross‐species comparison of its cytochrome P450 induction pattern
Authors: Treiber Alexander , Delahaye Stephane , Seeland Swen , Gnerre Carmela 
Published: July 2020

AbstractThe dual endothelin receptor antagonist macitentan was approved in 2013 for the treatment of pulmonary arterial hypertension. Macitentan is an inducer of cytochrome P450 expression in vivo in animal species but not in man. In rat and dog, changes in P450 expression manifest as autoinduction upon repeat dosing. The induction pattern, however, significantly differed between both species, and between male and female rats. While macitentan exposure steadily declined with dose in the dog, P450 induction was saturable in the rat reaching levels of 40%‐60% and 60%‐80% at steady‐state in male and female animals, respectively. The nature and number of P450 enzymes involved in macitentan clearance were identified as a major reason for the observed species differences. In the dog, macitentan was metabolized by a single P450 enzyme, that is, Cyp3a12, whereas several members of the Cyp2c and Cyp3a families were involved in the rat. Macitentan selectively upregulated Cyp3a expression in rat, whereas the expression of the Cyp2c enzymes involved in macitentan metabolism remained mostly unchanged, eventually leading to a higher contribution of Cyp3a upon induction. Macitentan also induced CYP3A4 expression in human hepatocytes via initial activation of the human pregnane X receptor. No such induction was evident in humans at the therapeutic macitentan dose of 10 mg as shown in a clinical drug‐drug interaction study with the CYP3A4 substrate sildenafil.
Young adults' return migration from large cities in Sweden: The role of siblings and parents
Authors: Mulder Clara H. , Lundholm Emma , Malmberg Gunnar 
Published: July 2020

AbstractLiving in cities affects young adults' access to education and work. With the use of register data for 2000–2013, we examined the role of having siblings and parents living close by and having siblings and parents living in the area of origin, in young adults' return migration from the four largest cities in Sweden. We found that young adults were less likely to return, and also less likely to migrate elsewhere, if they had siblings or parents living in the city of residence than if this was not the case. If the parents no longer lived in the region of origin, the young adults were very unlikely to return. Young adults were more likely to return if they had siblings living in that region than if they had no siblings or the siblings lived elsewhere. Adverse circumstances such as dropping out of tertiary education, low income, and unemployment were associated with a greater likelihood of return migration.
Second SVC stent treatment for tumour ingrowth
Authors: Takahara Yutaka , Ishige Yoko , Shionoya Ikuyo , Fujimoto Yuki , Oikawa Taku , Mizuno Shiro 
Published: July 2020

Key messageWe herein report a case of lung cancer with recurrent superior vena cava (SVC) syndrome, which was treated with additional stent placement. Our report suggests the possibility that additional SVC stent placement is an option for treatment of tumour ingrowth, even in patients with poor performance status.
Using heat to kill SARS‐CoV‐2
Authors: Abraham John P. , Plourde Brian D. , Cheng Lijing 
Published: July 2020

SummaryThe current coronavirus pandemic has reached global proportions and requires unparalleled collective and individual efforts to slow its spread. One critically important issue is the proper sterilization of physical objects that have been contaminated by the virus. Here, we review the currently existing literature on thermal inactivation of coronavirus (SARS‐CoV‐2) and present preliminary guideless on temperatures and exposure durations required to sterilize. We also compare these temperatures/exposure durations with potential household appliances that may be thought capable of performing sterilization.
Risks of producing and using indicators of sustainable development goals
Authors: Lyytimäki Jari , Salo Hanna , Lepenies Robert , Büttner Leonie , Mustajoki Jyri 
Published: July 2020

AbstractThe Sustainable Development Goals (SDG) aim to provide humanity with a global roadmap to sustainability. Official SDG indicators have been intensively developed, and they have a prominent and pronounced role as a key monitoring and policy instrument. Furthermore, various complementary or alternative indicator sets have been introduced at the global, regional and national levels. This article focuses on the risks related to the national indicators. The analysis is based on experiences from the preparation processes of sustainable development indicators in Finland and insights from indicator professionals and stakeholders in Finland and Germany. The risks related to overuse, nonuse and misuse of indicators are analyzed from the perspectives of indicator contents, processes of production and communication and external context factors. Opportunities for avoiding different risks and improving the desired societal impacts and influences of indicator usage are discussed. The concept of risk is helpful in terms of empirical diagnosis and for formulating mitigation recommendations.
Green Preparation of Few‐Layer Graphene Sheet Materials Using Naturally Occurring Calcium Carbonate and Plant Leaves
Authors: Xing Baoyan , Zhao Jianguo , Pan Qiliang , Yang Hui , Wang Lihua , Qu Wenshan , Gu Ling , Wang Haiqing , Han Peide , Ma Guibin 
Published: July 2020

AbstractGraphene sheets were prepared by calcination of calcium carbonate with plant leaves under the protection of an argon gas atmosphere. This is an environmentally friendly approach to produce graphene. Calcium carbonate decomposes with the evolution of carbon dioxide at high temperature, which is reduced into graphene by the magnesium from plant leaves. The formation mechanism of graphene is discussed in detail. The synthesized graphene sheets were characterized by scanning electron microscopy (SEM), X‐ray diffraction (XRD), and Raman spectroscopy. Calcium carbonate and plant leaves are readily available and inexpensive natural resources, and this new methodology can be applied for large‐scale graphene production in industry.
Exploring the Effect of Morphologies of Fe(III) Metal‐Organic Framework MIL‐88A(Fe) on the Photocatalytic Degradation of Rhodamine B
Authors: Viswanathan Vandana P. , Mathew Siji V. , Dubal Deepak P. , Adarsh Nayarassery N. , Mathew Suresh 
Published: July 2020

AbstractMetal‐organic frameworks built from [Fe3(μ3‐O)(COO)6] clusters and fumaric acid ligand, the so‐called MIL‐88 A(Fe) is a well‐known environment‐friendly promising material for many applications. In this paper, three different morphologies of MIL‐88 A(Fe) such as rod, diamond and spindle have been synthesized separately by reacting FeCl3•6H2O and fumaric acid in 1 : 1 metal‐ligand stoichiometric ratio using two different solvents such as water and DMF via hydrothermal method. The morphology of the products and their particle sizes were obtained using SEM and three distinct morphologies viz., rod, diamond and spindle were clearly distinguished by TEM. All the three samples were characterized by FT‐IR, PXRD, UVDRS, PL, XPS and BET, and the effect of the morphologies of MIL‐88 A(Fe) on the photocatalytic degradation of Rhodamine B (RhB) was studied under sunlight. The addition of an H2O2 electron acceptor can markedly enhance the photocatalytic Rhodamine B degradation of MIL‐88 A(Fe). Among these three, rod‐shaped morphology of MIL‐88 A(Fe) shows the higher photocatalytic effect for the degradation of Rhodamine B under sunlight due to its lower band gap, high surface area, and lower electron‐hole recombination rate which enable them the transfer of electrons for the photocatalytic degradation. We found that 98% degradation of RhB in 50 min has taken place by using r‐MIL‐88 A(Fe) as the catalyst under sunlight.
Free Radical Triggered Convenient Synthesis of Bis(indolyl)methane with Potassium Peroxodisulfate as Catalyst
Authors: Konwar Dipika , Bora Utpal 
Published: July 2020

AbstractThe free radical triggered convenient synthesis of bis(indolyl)methane using various indole and aldehyde derivatives with potassium peroxodisulfate as catalyst under the ambient conditions is developed. This protocol exhibits a wide range of sterically and electronically diverse substrate scope with good to excellent yield (up to 94 %) of the desired product without aﬀecting the bromo, chloro, iodo, nitro, methoxy, and hydroxyl groups. The experimental observation indicates that the reaction follow a radical pathway.
The corporate parenting advantage, revisited
Authors: Feldman Emilie R. 
Published: July 2020

AbstractResearch SummaryThis paper investigates the corporate parenting advantage, the extent to which corporate parents improve the performance of their subsidiaries. Despite the importance of this concept for corporate strategy, researchers have yet to quantify it empirically. I measure the corporate parenting advantage by comparing the performance of utilities that were legally classified into one of two types of holding companies: regulated holding companies, which faced limits on their ability to parent, and exempt holding companies, which did not. I find that observationally similar utilities that were owned by exempt holding companies outperform utilities that were owned by regulated holding companies, and that this performance differential attenuates once the legal restrictions on parenting were lifted. These results provide the first large‐scale empirical evidence of the corporate parenting advantage.Managerial SummaryBy how much do corporate parents improve the performance of their subsidiaries? Despite the importance of this question of the “corporate parenting advantage,” it does not yet have a clear answer. In this paper, I measure the corporate parenting advantage by comparing the performance of utilities that were legally grouped into one of two types of holding companies: regulated holding companies, which faced limits on their ability to parent, and exempt holding companies, which did not. I find that comparable utilities that were owned by regulated holding companies have lower return on assets than utilities that were owned by exempt holding companies, and that this performance difference disappears once the legal restrictions on parenting were lifted. These results provide evidence of the corporate parenting advantage.
A High‐Energy‐Density Hybrid Supercapacitor with P‐Ni(OH)2@Co(OH)2 Core–Shell Heterostructure and Fe2O3 Nanoneedle Arrays as Advanced Integrated Electrodes
Authors: Li Kunzhen , Zhao Bangchuan , Bai Jin , Ma Hongyang , Fang Zhitang , Zhu Xuebin , Sun Yuping 
Published: July 2020

AbstractTransition metal hydro/oxides (TMH/Os) are treated as the most promising alternative supercapacitor electrodes thanks to their high theoretical capacitance due to the various oxidation states and abundant cheap resources of TMH/Os. However, the poor conductivity and logy reaction kinetics of TMH/Os severely restrict their practical application. Herein, hierarchical core–shell P‐Ni(OH)2@Co(OH)2 micro/nanostructures are in situ grown on conductive Ni foam (P‐Ni(OH)2@Co(OH)2/NF) through a facile stepwise hydrothermal process. The unique heterostructure composed of P‐Ni(OH)2 rods and Co(OH)2 nanoflakes boost the charge transportation and provide abundant active sites when used as the intergrated cathode for supercapacitors. It delivers an ultrahigh areal specific capacitance of 4.4 C cm−2 at 1 mA cm−2 and the capacitance can maintain 91% after 10 000 cycles, showing an ultralong cycle life. Additionally, a hybrid supercapacitor composed with P‐Ni(OH)2@Co(OH)2/NF cathode and Fe2O3/CC anode shows a wider voltage window of 1.6 V, a remarkable energy density of 0.21 mWh cm−2 at the power density of 0.8 mW cm−2, and outstanding cycling stability with about 81% capacitance retention after 5000 cycles. This innovative study not only supplies a newfashioned electronic apparatus with high‐energy density and cycling stability but offers a fresh reference and enlightenment for synthesizing advanced integrated electrodes for high‐performance hybrid supercapacitors.
Efficient Bifunctional Catalytic Electrodes with Uniformly Distributed NiN2 Active Sites and Channels for Long‐Lasting Rechargeable Zinc–Air Batteries
Authors: Cai Zihe , Lin Shengxuan , Xiao Jiajia , Muhmood Tahir , Chen Yuhang , Wang Yifan , Hu Xiaobin , Zheng Lirong 
Published: July 2020

AbstractFreestanding bifunctional electrodes with outstanding oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) properties are of great significance for zinc–air batteries, attributed to the avoided use of organic binder and strong adhesion with substrates. Herein, a strategy is developed to fabricate freestanding bifunctional electrodes from the predeposited nickel nanoparticles (Ni‐NCNT) on carbon fiber paper. The steric effect of monodispersed SiO2 nanospheres limits the configuration of carbon atoms forming 3D interconnected nanotubes with uniformly distributed NiN2 active sites. The bifunctional electrodes (Ni‐NCNT) demonstrate ideal ORR and OER properties. The zinc–air batteries assembled with Ni‐NCNT directly exhibit extremely outstanding long term stability (2250 cycles with 10 mA cm−2 charge/discharge current density) along with high power density of 120 mV cm−2 and specific capacity of 834.1 mA h g−1. This work provides a new view to optimize the distribution of active sites and the electrode structure.
Research on the maturity of big data management capability of intelligent manufacturing enterprise
Authors: Ge Jing , Wang Feng , Sun Hongxia , Fu Liuliu , Sun Mingwei 
Published: July 2020

AbstractFrom the perspective of intelligent manufacturing, combined with cyber‐physical system, big data, Internet of things, cloud computing, industrial transformation and value chain concepts, this paper studies digital manufacturing, also called intelligent manufacturing. Intelligent manufacturing is explored from the perspective of the supply chain and industry chain. In this paper, other topics in the integrated big data‐driven intelligent manufacturing is also discussed.
Report of the Nomenclature Committee for Fossils: 13
Authors: Herendeen Patrick S. 
Published: July 2020

SummaryThe following three generic names are recommended for conservation: Vestispora against Reticulatasporites, Acitheca against Strephopteris, and Lyginopteris against Dictyoxylon. The following species name is recommended for conservation: Cyclostigma kiltorkense against Lepidodendron griffithii, L. minutum, and Sigillaria dichotoma. The following two family names are recommended for conservation: Umkomasiaceae against Zuberiaceae, and Discinitaceae against Palaeopteridiaceae and Saaropteridaceae. The following two generic names are not recommended for conservation: Autophyllites against Bryon, and Protocupressinoxylon with a conserved type against Protobrachyoxylon. The following one species name is not recommended for conservation: Autophyllites furcatus against Bryon crispatum. The Committee judged the differential diagnosis for the name Pinites to be adequate for valid publication. The Committee judged the descriptive statements associated with Celastrophyllum Göpp., Celastrophyllum Ettingsh. ex Saporta & Marion, and Celastrophyllum Ettingsh. ex Schimp. to be inadequate for valid publication. In addition, this report includes a summary of a re‐evaluation of the date and place of publication of the generic name Cardiocarpus Brongn., which had been called into question.
Analytic double-soft integrated subtraction terms for two massive emitters in a back-to-back kinematics
Authors: Bizoń Wojciech , Delto Maximilian 
Published: July 2020

Abstract
We consider the double-soft limit of QCD amplitudes with two massive quarks in a back-to-back kinematics accompanied by two soft partons. We integrate analytically the respective double-soft eikonal functions over the phase space of the two soft partons. Within the context of the nested soft-collinear subtraction scheme, our results may serve as one of the integrated subtraction terms needed for the analytic and fully-differential description of next-to-next-to-leading order (NNLO) QCD corrections to colour-singlet decay into massive partons or to heavy-quark pair production.
Ovals in $${\mathbb {Z}}^2_{2p}$$
Authors: Stȩpień Zofia 
Published: July 2020

AbstractBy an oval in$${\mathbb {Z}}^2_{2p},$$Z2p2,podd prime, we mean a set of$$2p+2$$2p+2points, such that no three of them are on a line. It is shown that ovals in$${\mathbb {Z}}^2_{2p}$$Z2p2only exist for$$p=3,5$$p=3,5and they are unique up to an isomorphism.
Is antibiotic prophylaxis necessary in mid-urethral sling surgery?
Authors: Svenningsen Rune , Kulseng-Hanssen Sigurd , Kråkenes Ellen Bettina Casanova , Schiøtz Hjalmar August 
Published: July 2020

Abstract
Introduction and hypothesis
Antibiotic prophylaxis is commonly used when implanting a mid-urethral sling (MUS) for female stress urinary incontinence. Use of antibiotics may lead to adverse events and the development of antibiotic resistance. This study compared a variety of outcomes after MUS surgery with and without antibiotic prophylaxis using data from the national Norwegian Female Incontinence Registry.

Methods
Preoperative and 6–12 months postoperative subjective and objective data from 28,687 patients who received MUS surgery from 1998 through 2017 were extracted from the registry. Categorical outcomes were compared between women with or without antibiotic prophylaxis using chi-square test for independence. Primary outcome was incidence of postoperative surgical site infection (SSI). Secondary outcomes were incidence of tape exposure, de novo or persistent urgency urinary incontinence, postoperative pain > 3 months, subjective and objective cure rates, and patient satisfaction.

Results
Antibiotic prophylaxis was used in 9131 and not used in 19,556 patients. SSIs and prolonged postoperative pain occurred significantly more often without antibiotic prophylaxis. Subjective and objective cure rates were significantly higher and tape exposures significantly lower in women not receiving prophylactic antibiotics. There were no significant differences in other outcomes.

Conclusions
Antibiotic prophylaxis resulted in fewer women developing postoperative infections or prolonged postoperative pain after MUS surgery, but did not offer protection against tape exposure. The differences in cure rates were small and probably without clinical relevance. If a small increase in surgical site infections is accepted, the routine use of antibiotic prophylaxis can probably be omitted.
Action force modulates action binding: evidence for a multisensory information integration explanation
Authors: Cao Liyu , Steinborn Michael , Kunde Wilfried , Haendel Barbara 
Published: July 2020

AbstractAction binding refers to the observation that the perceived time of an action (e.g., a keypress) is shifted towards the distal sensory feedback (usually a sound) triggered by that action. Surprisingly, the role of somatosensory feedback for this phenomenon has been largely ignored. We fill this gap by showing that the somatosensory feedback, indexed by keypress peak force, is functional in judging keypress time. Specifically, the strength of somatosensory feedback is positively correlated with reported keypress time when the keypress is not associated with an auditory feedback and negatively correlated when the keypress triggers an auditory feedback. The result is consistent with the view that the reported keypress time is shaped by sensory information from different modalities. Moreover, individual differences in action binding can be explained by a sensory information weighting between somatosensory and auditory feedback. At the group level, increasing the strength of somatosensory feedback can decrease action binding to a level not being detected statistically. Therefore, a multisensory information integration account (between somatosensory and auditory inputs) explains action binding at both a group level and an individual level.
Neutral effect of an invasive plant species with specialized flower structure on native pollinator communities
Authors: Szigeti Viktor , Fenesi Annamária , Soltész Zoltán , Berki Boglárka , Kovács-Hostyánszki Anikó 
Published: July 2020

AbstractInvasive plants modify native plant communities with serious consequences on plant-pollinator interactions. Invasion by common milkweed (Asclepias syriacaL.) threatens natural and agricultural habitats in Europe, with unknown effects on pollinators. Its special flower structure, habitat requirements and phenology offer novel insights into pollination ecology aspects of plant invasion. We compared flowering plant and pollinator communities between invaded and control sites, and the flower visitors between native plants and common milkweed. Wild bees and hoverflies did not differ in abundance, diversity and community composition between the invaded and control sites. However, honey bees and bumble bees preferred milkweed above native plants during milkweed flowering. In contrast to many studies, our results suggest neutral effect of plant invasion on the sampled aspects of diurnal wild pollinator community, while providing resources for a few pollinator taxa. This neutral effect might be explained by the long-term, wide scale distribution of milkweed and/or its typically relatively low coverage compared to many other invasive plants, enabling the persistence of some native flowering species. However, its special flower structure offers nectar only for a few common pollinators, including honey bee, and it decreases abundance of native flowers in spring with unknown consequences on wild bees’ reproduction success. Despite the lack of direct negative effects on wild pollinators, restoration of invaded habitats to promote native floral communities is suggested to enable diverse, longer lasting foraging resources for wild pollinators and honey bees. Promoting actively wildflower habitats might be vital for beekeepers in the case of milkweed eradication.