bluuebunny/crossref_metadata_2025_split huggingface dataset:
MATRIZ DISCIPLINAR DE Já–RN RáœSEN: Uma reflexão sobre os princá­pios do conhecimento histórico
Authors: Silva Rogério Chaves da 
Published: December 2020

Neste artigo, analiso a concepção de ciência da história de Já¶rn Rá¼sen a partir de seu conceitode matriz disciplinar. Através desse conceito, procuro refletir sobre as complexas relações entreconhecimento histórico e vida prática, e entre pesquisa e escrita da história.
MARQUáŠS DE SADE: Entre a realidade e a ficção
Authors: Silva Carla Fernanda da 
Published: December 2020

Este artigo propõe uma discussão sobre a literatura erótica e inicia com uma reflexãogenealógica da ordenação do desejo na mitologia grega, demonstrando a fuga da espontaneidadepresente em Eros em detrimento de seu irmão Anteros (Ordem). Pensando a partir do confronto de Erose Anteros, fez-se um recorte da obra do Marquês de Sade e, então, uma reflexão crá­tica da concepção doerótico e da ordem presentes em suas obras, com destaque para ”˜Os 120 dias de Sodoma”™. Ao pesquisarsua obra, concebida durante os internamentos em sanatórios e prisões, percebem-se seus escritos comodisciplinadores do sexo, nos quais o autor não pensa o erótico como uma possibilidade do compartilhardos corpos e do desejo, mas sim como a destruição moral e, por vezes, fá­sica do Outro.
CONTOS ALINHAVADOS: A participação de Machado de Assis em periódicos de moda e literatura
Authors: Silveira Daniela Magalhães da 
Published: December 2020

Este artigo analisa a participação de Machado de Assis em dois periódicos articulados comvistas ao público feminino: o Jornal das Famá­lias e A Estação. Num perá­odo de implementação ecrescimento do número de jornais e revistas publicados no Brasil, conquistar as leitoras parecia seruma boa estratégia. Alguns nomes reconhecidos de nossa literatura mostraram-se bastanteempenhados em escrever para e sobre as mulheres. Machado de Assis, logo no iná­cio de sua carreira,publicou um número considerável de histórias curtas para as ”gentis leitoras”. Este estudo sugerealguns dos possá­veis significados que tiveram para Machado participar do corpo de colaboradores deperiódicos de moda e literatura. Observaremos, portanto, como essas revistas foram influenciadas etambém marcaram a trajetória e caminhos escolhidos pelo literato.
O "CASO DOS SOUZA CASTRO": Itinerários de dois pesquisadores do Centro de Estudos Afro-Orientais na Nigéria (1962-1963)
Authors: Reis Luiza Nascimento dos 
Published: December 2020

No iná­cio da década de 1960, o recém-fundado Centro de Estudos Afro-Orientais daUniversidade Federal da Bahia aglutinou jovens pesquisadores com o objetivo de fomentar umintercá¢mbio acadêmico com paá­ses do continente africano. Para o diretor-fundador Agostinho da Silvainteressava uma aproximação cultural. Para os pesquisadores, como Guilherme de Souza Castro eYêda Pessoa de Castro, buscava-se investigar conexões religiosas entre a Bahia e determinados paá­sesda áfrica Ocidental. Da convergência desses interesses resultou a singular experiência do então casal”Souza Castro” na Nigéria, onde estiveram entre 1962 e 1963. As dificuldades estruturais e asexperiências da pesquisa no continente africano informam sobre meandros da polá­tica africana postaem curso pelo Brasil.
O áŠXODO DA MINORIA BRANCA DE ANGOLA Adaptações ao contexto brasileiro
Authors: Barreto Isabel de Souza Lima 
Published: December 2020

Este trabalho visa refletir sobre o processo de adaptação de migrantes que chegaram ao Brasil entrefins de 1974 e o ano de 1976 por conta do processo de descolonização de Angola. Há aqueles que migraramcom recursos próprios diretamente para o Brasil; há quem tenha vivido um perá­odo em Portugal ou áfrica doSul antes de se fixar permanentemente no Brasil. Quando chegaram aqui, alguns encontraram facilidades noprocesso de acolhimento e adaptação. São esses: parentes que já viviam no Rio de Janeiro, facilidadesoferecidas pelo governo brasileiro para tirar documentos de permanência, assistência de instituições dacomunidade portuguesa, e até mesmo ajuda de pessoas desconhecidas. A adaptação, entretanto, não foi fácilpara todos. Há, entretanto, quem tenha passado por dificuldades iniciais. Para dar uma melhor compreensão dachegada desses imigrantes, faremos referências á guerra colonial, á questão racial e ao processo dedescolonização.
A PROVáNCIA LITERáRIA DOS "NOVOS": O. G. Rego de Carvalho e as polêmicas intelectuais teresinenses da metade do século XX
Authors: Andrade José Maria Vieira de 
Published: December 2020

Neste trabalho, discute-se a atuação e a produção intelectual do literato piauiense OrlandoGeraldo Rego de Carvalho e de alguns de seus contemporá¢neos ”“ escolhidos aqui enquanto pretexto paraa análise das transformações culturais vivenciadas ou experimentadas pela sociedade teresinense nametade do século XX ”“ procurando fazer um confronto entre a experiência intelectual protagonizada poresses sujeitos e as mudanças culturais ocorridas na cidade, nesse perá­odo. Entre as questões centrais aserem discutidas, daremos ênfase á s polêmicas e debates protagonizados pelo literato em questão, tendoem vista as mudanças ocorridas nas condições de vida urbana, bem como da relação existente entre essasmudanças e os projetos de renovação da produção literária piauiense, elaborados no perá­odo.
APLIKASI PELAPISAN NANOKOMPSIT UNTUK MEMPERTAHANKAN KUALITAS SALAK PONDOH (Salacca edulis Reniw)
Authors: Gumaran Setyadi , Sutrisno NFN , Iriani Evi Savitri 
Published: December 2020

<p>Pelapisan nanokomposit dapat meningkatkan karakteristik fisik, mekanis serta fungsional dari bahan pelapis. Penelitian ini bertujuan untuk mengetahui pengaruh pelapisan nanokomposit dengan berbagai polimer (gelatin dan kitosan) yang ditambahkan seng <em>oksida dan beeswax</em> untuk menjaga kualitas salak pondoh selama penyimpanan. Hasilnya menunjukkan bahwa penambahan emulsi <em>beeswax</em> dan <em>NP-ZnO</em> dapat menurunkan nilai WVTR dari 25.6 menjadi 13.75 g/m<sup>2</sup>jam. Penambahahan <em>beeswax </em>dan <em>NP-ZnO</em> juga dapat merubah sifat antimikroba film kitosan dan gelatin. Aplikasi nanokomposit mampu menurunkan kehilangan berat salak pondoh selama penyimpanan dibandingkan dengan kontrol salak pondoh (P &lt;0,05). Kontrol salak memiliki nilai penurunan susut bobot tertinggi sebesar 18,57% sedangkan salak dengan perlakuan WC3 dan WG3 memiliki nilai 12,72% dan 13,92%, persentase kerusakan sebesar 76,19% pada hari ke 28 penyimpanan. Aplikasi pelapisan nanokomposit juga mampu mempertahankan kekerasan dan persen tingkat kerusakan selama penyimpanan.</p><p> </p><p><strong>Application of nanocomposite based on Chitosan and Gelatin to maintain quality of Salacca fruit. (</strong><strong><em>Salacca e</em></strong><strong><em>dulis </em></strong><strong>Reniw).</strong></p><p>Nanocomposite coating could enhance the physical and mechanical characteristic as well as functional of material coatings. This research aimed to determine the application of nanocomposite coating with various polymers (gelatin and chitosan) which added zinc oxide and beeswax to maintain the quality of salak pondoh during storage. The result showed that the addition of beeswax emulsion and ZnO-NPs significantly decreased WVTR value from 25.6 to 13.75 g/m<sup>2</sup> hours. The addition of beeswax emulsion and ZnO-NPs also changed the antimicrobial properties of chitosan and gelatin films Aplication of nanocomposite coating was able to decrease the weight loss of salak pondoh during storage compared to salak pondoh control (P &lt;0.05). Salak control has the largest weight loss value of 18.57% while salak with WC3 and WG3 treatment has a value of 12.72% and 13.92%, percentage of decai has value 76.19% on 28 days storage. Application of nanocomposite coating are also able to maintain quality such as firmness and percentage of decay during storage.</p>
FORMULASI, KARAKTERISASI, DAN OPTIMASI WAKTU REHIDRASI PRODUK NASI KUNING INSTAN
Authors: Widowati Sri , Asni Nur , Nuraeni Farida 
Published: December 2020

<p>Nasi kuning instan menjadi salah satu alternatif menu sarapan pagi karena memiliki waktu penyajian yang singkat. Tujuan penelitian ini adalah untuk menghasilkan formula terbaik produk nasi kuning instan dengan waktu rehidrasi yang optimum dan menentukan karakteristik fisikokimia produk nasi kuning instan. Faktor yang diuji adalah formulasi bumbu (kontrol dengan menggunakan bumbu instan, formula A menggunakan 1 paket bumbu nasi kuning, formula B menggunakan 1,25 paket bumbu nasi kuning dan formula C menggunakan 1,50 paket bumbu nasi kuning) dan kadar amilosa beras (rendah, sedang dan tinggi). Hasil uji analisis <em>one way anova</em> menunjukkan bahwa antara formulasi dan kadar amilosa beras berbeda secara nyata dari karakteristik fisikokimia nasi kuning instan (p&lt;0,05). Formula dan nasi kuning instan yang terpilih adalah formula 1,25 paket bumbu nasi kuning dari beras Sintanur dengan kadar amilosa rendah adalah waktu rehidrasi 4,59 menit, rendemen 90,23%, volume pengembangan 30,89%, daya serap air 49,68%, densitas kamba 0,62 g/mL, nilai °<em>Hue</em> diatas 90%, dan nilai kekerasan 74,03%. Produk ini mengandung kadar air 8,07%, abu 3,35%, protein 9,19%, lemak 2,08%, karbohidrat 76,32%, dan kadar pati 64,11 %.</p><p> </p><p><strong>Formulation, Characterization, and Optimization of the Rehydration of Yellow Rice Instant.</strong></p><p>Instant yellow rice is an alternative to breakfast because it has a short testing time. The purpose of this study was to produce the best formula for instant yellow rice products with optimum rehydration time and determine the physicochemical characteristics of instant yellow rice products. Factors tested were seasoning formulations (control using instant seasoning, formula A using 1 package of yellow rice seasoning, formula B using 1,25 package of yellow rice seasoning and formula C using 1,50 packages of yellow rice seasoning) and amylose content of rice (low, medium and high). One way ANOVA analysis results showed that between the formulation and amylose content of rice was significantly different from the physicochemical characteristics of instant yellow rice (p &lt;0,05). The formula and instant yellow rice selected were formula 1,25 package of yellow rice seasoning from Sintanur rice with low amylose content, rehydration time 4,59 minutes, yield 90,23%, development volume 30,89%, water absorption 49,68%, kamba density 0,62 g/mL , the ° Hue value is above 90%, and the hardness value is 74,03%. This product contains 8,07% water content, 3,35% ash, 9,19% protein, 2,08% fat, 76,32% carbohydrate, and 64,11% starch content.</p>
Long Term Outcome of Combined Phacoemulsification and Excisional Goniotomy with the Kahook Dual Blade in Different Subtypes of Glaucoma
Authors: Habash Ahmed Al , Buainain Abdulrahman Al 
Published: December 2020

Abstract
Purpose: To characterize changes in intraocular pressure (IOP), IOP-lowering medications, and visual acuity (VA) through 3 years of follow-up in patients undergoing combined phacoemulsification and excisional goniotomy with the Kahook Dual Blade (phaco-KDB), with simultaneous goniosynechialysis in cases of angle-closure glaucoma, by a single surgeon (A.H.) in King Fahd Hospital of the University, Dammam, Saudi Arabia.Methods: Prospective, non-comparative, uncontrolled, non-randomized interventional case series. Consecutive patients with medically-treated glaucoma and visually-significant cataract underwent combined surgery. Subgroup analysis of glaucoma subtypes was performed.Results: Fifty-seven eyes (48 patients) including 29 eyes with primary open-angle glaucoma, 15 with pseudoexfoliation glaucoma, and 13 with angle-closure glaucoma, were enrolled. Mean (standard error) baseline IOP was 20.3 (0.7) mmHg and through up to 36 months of follow-up (minimum 12 months, mean 26.2 [1.0] months) ranged from 13.5-14.0 mmHg (13.7 mmHg at Month 36); significant reductions (p<0.0002) of 23.6-29.9% were achieved at every time point. Medications were reduced from a mean of 3.3 (0.1) to 0.2-1.9 (reduction 51.4-94.7%; p<0.0001 at every time point). Mean logMAR VA improved from 0.97 (0.11) preoperatively to 0.25 (0.04) by Month 6 (p<0.0001), remaining stable thereafter. Outcomes were similar in POAG, pseudoexfoliation, and ACG subgroups. Hyphema occurred and resolved spontaneously in 6 eyes; 1 eye had elevated IOP on postoperative day 1.Conclusions: Phaco-KDB significantly improved VA, lowered IOP ~25-30%, and lowered medications by >50% through 36 months. This combined procedure provides meaningful long-term reductions in IOP and need for IOP-lowering medication without compromising visual rehabilitation in eyes with cataract and glaucoma.
Cytoplasmic Male Sterility-Associated Mitochondrial Gene orf312 Derived from Rice (Oryza Sativa L.) Cultivar Tadukan
Authors: Takatsuka Ayumu , Kazama Tomohiko , Toriyama Kinya 
Published: December 2020

Abstract
BackgroundCytoplasmic male sterility (CMS) is a trait associated with non-functional pollen or anthers, caused by the interaction between mitochondrial and nuclear genes. FindingsA Tadukan-type CMS line (TAA) and a restorer line (TAR) were obtained by successive backcrossing between the Oryza sativa cultivars Tadukan (a cytoplasmic donor) and Taichung 65 (a recurrent pollen parent). Using Illumina HiSeq, we determined whole-genome sequences of the mitochondria of TAA and screened the mitochondrial genome for the presence of open reading frame (orf) genes specific to this genome. One of these orf genes, orf312, showed differential expression patterns in TAA and TAR anthers at the meiotic and mature stages, with transcript amounts in TAR being less than half of those in TAA. The orf312 gene is similar to the previously described orf288, a part of which is among the components comprising WA352, a chimeric CMS-associated gene of wild-abortive-type CMS. Conclusions﻿The orf312 gene is a promising candidate for CMS-associated gene in TAA.
Superoxide Dismutase (SOD): From Genomics and Expression Profiling to Heritability and Phenotypic Variability in Triticale Under Drought Stress
Authors: Saed-Moucheshi Armin , Sohrabi Fatemeh , Fasihfar Elham , Baniasadi Fatemeh , Riasat Mehrnaz , Mozafari Ali Akbar 
Published: December 2020

Abstract
BackgroundThe main objectives of the current study were to find the possible structural association between the activity of enzymatic antioxidants and grain yield of triticale plants along with identify the genotypic variability of SOD activity among different triticale elite genotypes using novel statistical methods. Additionally, the difference between expression rate of SOD isozymes (Mn-SOD, Cu/Zn-SOD, and Fe-SOD) were tested to find out about the relationship between expression rate and the drought resistance of triticale selected genotypes. The final goal of this study was to introduce source code in SAS language to estimate the genetic parameters based on combined ANOVA model that could be applicable in all field studies.MethodsThirty genotypes of triticale were studied during six years in three different locations to model the relationship of enzymatic antioxidants and grain yield under drought stress condition. In every year, two separate field trials were used to assess the effect of normal irrigation (irrigation trial) and drought stress conditions (stress trials) by withholding irrigation at early heading stage. Accordingly, based on the results of genetic variability, heatmap analysis, biplot graph, and clustering, two genotypes with the highest genetic distance were selected to appraise the differential expression profiling of three SOD isozyme in shoot and root organs.ResultsField experiments and bioinformatics results showed that superoxide dismutase (SOD) was the most influential antioxidant in triticale tolerance to drought stress. Additionally, Mn-SOD showed high expression levels for both genotypes but with higher rates in tolerant genotype. Also, Mn-SOD expression rate in shoot was higher than root, but the expression level of Fe-SOD was conversely higher in the root. Additionally, Fe-SOD expression levels showed no significant difference in two used genotypes. The expression level of Cu/Zn-SOD was higher in root of the tolerant genotype while lower in root of susceptible genotype, as compared with their shoot.ConclusionHeatmap analysis that is applied for the first time in a screening program, showed to be highly capable of distinguishing elite genotypes and pointing out the proper features for selection criteria. Bioinformatics results indicated that SOD is more important than other enzymatic antioxidant for being considered as selection criteria or candidate gene for transgenic purposes. Based on expressional results, Mn-SOD announced as general isozyme that probably is highly expressed in most of the species, while, Cu/Zn-SOD as was introduced as a genotype specific isozyme that is likely more expressed in tolerant genotypes of triticale.
Ultrasound Targeted Microbubble Destruction Combined With Fe-MOF&nbsp;Based Bio-/Enzyme-Mimics&nbsp;Nanoparticles for Treating of Cancer
Authors: Xiang Xi , Pang Houqing , Ma Tian , Du Fangxue , Li Ling , Huang Jianbo , Ma Lang , Qiu Li 
Published: December 2020

Abstract
Background: Cancer urgently needs a new strategy for its recurrence and treatment resistance with the existing treatments. Fe-based metal-organic frameworks (MOFs) had the potential in ROS generation due to Fenton catalysis, which has been shown to be effective in antitumor therapy. However, Fenton catalysis requires sufficient H2O2 as the reactant to generate hydroxyl radical. Therefore, further improvement of Fe-MOF is needed. In the research, bio-/enzyme-mimics nanoparticles FeN200@GOx@M were synthesized and were used combined with ultrasound targeted microbubble destruction (UTMD) as a novel method for cancer therapy. Methods: FeN200@GOx@M was synthesized by loading GOx and encapsulating tumor cell membrane. The nanostructures were characterized by SEM, TEM, XRD, EDS, XPS, and so on. The anti-tumor efficiency of FeN200@GOx@M was evaluated by cytotoxicity test, live/dead cell staining and apoptosis ratio in vitro. The combination of FeN200@GOx@M and UTMD was applied in vivo to verify the enhancement of anti-tumor effect of UTMD on FeN200@GOx@M.Results: FeN200@GOx@M was successfully synthesized. FeN200@GOx@M was most easily intake by A2780 tumor cells, generated the most ROS in tumor cells, and induced the most apoptotic tumor cells in vitro. In addition, UTMD technology further improved the anti-tumor efficiency in vivo due to its sonoporation, which helped create reversible holes in cell membranes for easier been destroyed by FeN200@GOx@M. Conclusion: Fe-MOF based bio-/enzyme-mimics nanoparticles FeN200@GOx@M had excellent anti-tumor efficiency. And UTMD can improve the therapeutic effectiveness. The combination of FeN200@GOx@M and UTMD provided a novel, safe, and efficient treatment strategy for cancer.
Green Phellodendri Chinensis Cortex-based Carbon Dots for Ameliorating Imiquimod-induced Psoriasis-like Inflammation in Mice
Authors: Zhang Meiling , Cheng Jinjun , Hu Jie , Luo Juan , Zhang Yue , Lu Fang , Kong Hui , Qu Huihua , Zhao Yan 
Published: December 2020

Abstract
Background: Carbon dots with multifaceted advantages have been provided hope for development brand-new nanodrug for treating thorny diseases.This study developed a green and simple calcination method to prepare novel cardon dots (CDs) as promising drug for psoriasis treatment. The as-prepared CDs using Phellodendri Chinensis Cortex (PCC) as sole precursor were characterized by a series of methods, mainly including electron microscopy, optical technology and X-ray photoelectron spectroscopy (XPS).Results: Results displayed that fluorescence (Quantum yield =5.63%) and nontoxic PCC-based CDs (PCC-CDs) with abundant chemical groups exhibited solubility and tiny sizes at average of (1.93 ± 0.53) nm, which may be beneficial for its inherent biological activity. Moreover, by using the typical imiquimod (IMQ) – induced psoriasis-like skin mouse model, we firstly demonstrated the pronounced anti-psoriasis activity of as-prepared PCC-CDs on ameliorating the appearance, psoriasis area and severity index (PASI) scores as well as histopathological morphology of both back tissues and right ears in IMQ-induced mouse. Further potential mechanisms behind the anti-psoriasis activities may be related to the anti-inflammation effects of PCC-CDs by descending the serum levels of proinflammatory cytokines (TNF-α, IL-6 and IL-17A). Conclusion: These results suggested that PCC-CDs have potential to be an anti-psoriasis candidate for clinical applications to treat psoriasis, which not only provided an evidence for further broadening the biological application of CDs, but also provided a potential hope for application nanodrugs to treat thorny diseases.
Further Engineering of R. Toruloides for the Production of Terpenes From Lignocellulosic Biomass
Authors: Kirby James , Geiselman Gina M. , Yaegashi Junko , Kim Joonhoon , Zhuang Xun , Tran-Gymfi Mary Bao , Prahl Jan-Philip , Sundstrom Eric R. , Gao Yuqian , Munoz Nathalie Munoz , Burnum-Johnson Kristin E. , Benites Veronica T. , Baidoo Edward E. K. , Fuhrmann Anna , Seibel Katharina , Webb-Robertson Bobbie-Jo M. , Zucker Jeremy , Nicora Carrie D. , Tanjore Deepti , Magnuson Jon K. , Skerker Jeffrey M. , Gladden John M. 
Published: December 2020

Abstract
Background: Mitigation of climate change requires that new routes for the production of fuels and chemicals be as oil-independent as possible. The microbial conversion of lignocellulosic feedstocks into terpene-based biofuels and bioproducts represents one such route. This work builds upon previous demonstrations that the single-celled carotenogenic basidiomycete, Rhodosporidium toruloides, is a promising host for the production of terpenes from lignocellulosic hydrolysates. Results:This study focuses on the optimization of production of the monoterpene 1,8-cineole and the sesquiterpene α-bisabolene in R. toruloides. The α-bisabolene titer attained in R. toruloides was found to be proportional to the copy number of the bisabolene synthase (BIS) expression cassette, which in turn influenced the expression level of several native mevalonate pathway genes. The addition of more copies of BIS under a stronger promoter resulted in production of α-bisabolene at 2.2 g/L from lignocellulosic hydrolysate in a 2 L fermenter. Production of 1,8-cineole was found to be limited by availability of the precursor geranylgeranyl pyrophosphate (GPP) and expression of an appropriate GPP synthase increased the monoterpene titer 4-fold to 143 mg/L at bench scale. Targeted mevalonate pathway metabolite analysis suggested that 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGR), mevalonate kinase (MK) and phosphomevalonate kinase (PMK) may be pathway bottlenecks are were therefore selected as targets for overexpression. Expression of HMGR, MK, and PMK orthologs and growth in an optimized lignocellulosic hydrolysate medium increased the 1,8-cineole titer an additional 10-fold to 1.4 g/L. Expression of the same mevalonate pathway genes did not have as large an impact on α-bisabolene production, although the final titer was higher at 2.6 g/L. Furthermore, mevalonate pathway intermediates accumulated in the mevalonate-engineered strains, suggesting room for further improvement. Conclusions:This work brings R. toruloides closer to being able to make industrially relevant quantities of terpene from lignocellulosic biomass.