bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in treatment strategy over time for arteriovenous malformation in a Japanese high-volume center
Authors: Komatsu Katsuya , Takagi Yasushi , Ishii Akira , Kikuchi Takayuki , Yamao Yukihiro , Yoshida Kazumichi , Miyamoto Susumu 
Published: September 2020

Abstract
Background: Despite rapid developments in devices used to treat arteriovenous malformation (AVM), a randomised trial of Unruptured Brain Arteriovenous malformations published in 2014 recommended conservative treatment for nonhemorrhagic AVM.Objective: The purpose of the current retrospective study was to confirm how AVM treatment in Japan has changed and to assess the safety of treatment for hemorrhagic and nonhemorrhagic AVMs.Methods: We enrolled 242 consecutive patients with AVM; each patient’s treatment was selected and performed at our hospital. The type of onset, Spetzler–Martin (S–M) grade, age, sex, selected treatment, mortality, and morbidity were compared between the first and second periods of our study.Results: In patients with grade I–III AVM, the selected treatment changed between the first and second periods; however, in grade IV and V patients, the selected treatment did not change. Overall, interventions by microsurgery alone decreased (p < 0.001), the proportion of total treatments including microsurgery decreased (p = 0.005), interventions using stereotactic radiosurgery (SRS) alone increased (p = 0.009), and interventions including SRS increased (p = 0.002). Morbidity associated with intervention was 0.92% in the first period and 0% in the second period, and mortality was 0.92% in the first period and 1.67% in the second.Conclusions: With the development of new devices, the selected treatment was changed in patients with S–M grade I–III AVM, but was not changed in patients with grade IV and V. The complication rate was low and did not change throughout the periods. These findings suggest that the safety of treatment depends on a full understanding of device development and the selection of proper treatment, not on hemorrhagic onset. Further treatment innovations are expected to change the treatment for grade IV and V AVMs.
More fuel to the fire: Some patients with non-celiac self-reported wheat sensitivity exhibit adaptive immunological responses in duodenal mucosa.
Authors: Castillo-Rodal Antonia Isabel , Furuzawa-Carballeda Janette , Pelaez-Luna Mario , Castro-Gomez Jose , Lopez-Vidal Yolanda , Uscanga Luis Federico 
Published: September 2020

Abstract
Background: In contrast to the well characterized Celiac Disease (CD), the clinical scenarios encompassed by non-celiac self-reported wheat sensitivity might be related to different antigens that trigger distinct immune-inflammatory reactions. Although an increased number of intestinal intraepithelial lymphocytes (IEL) is observed at the inception of both diseases, subsequent immunopathogenic pathways seem to be different. We aimed to describe the cytokine profile showcased by the duodenal mucosa of patients with self-reported wheat intolerance.Methods: In a blind, cross-sectional study, we included duodenal biopsies from 15 consecutive untreated patients with active CD, 9 individuals with self-reported NCSRWS and 10 subjects with dyspepsia without CD and food intolerances. Using Immunohistochemistry and flow- cytometry we determined the presence of pro-inflammatory cytokine expressing monocytes and monocyte-derived dendritic cells involved in innate immune activation, cytokine-driven polarization and maintenance of Th1 and Th17/Th22, and anti-inflammatory/profibrogenic cytokines. Results: The percentage of cells expressing all tested cytokines in lamina propria and epithelium was higher in CD patients than control group. Cytokines that induce and maintain Th1 and Th17 polarization were higher in CD than in NCSRWS and controls; and higher in NCSRWS compared to controls. Similar differences were detected in the expression of IL-4 and TGF- β1, while IL-10-expressing cells were lower in NCSRWS patients than in controls and CD subjects. Conclusions : NCSRWS patients exhibit components of both, innate and adaptive immune mechanisms but to a lesser extent compared to CD.
Clinical practice and postoperative rehabilitation after knee arthroscopy vary according to surgeons’ expertise: a survey among Polish Arthroscopy Society members.
Authors: Bąkowski Paweł , Bąkowska-Żywicka Kamilla , Piontek Tomasz 
Published: September 2020

Abstract
Background: Meniscus repair is a challenging task in knee arthroscopy. Currently, there are a variety of arthroscopic methods available for meniscus repair. The purpose of this study was to determine a consensus in meniscus tear treatment in the environment of Polish orthopaedists.Methods: A total of 205 registered orthopaedic surgeons participated in the surveys. The survey consisted of 35 questions regarding general arthroscopy and postoperative management, including physicians’ level of expertise, anaesthesia, postoperative treatment, rehabilitation and procedures performed. Comparisons were made between knee arthroscopy experts (> 100 arthroscopies performed per year) and non-experts (≤ 100 cases) on aspects of patient care.Results: The most important finding of this study was the agreement among almost all aspects of the knee arthroscopy approach. Consensus among Polish surgeons was noticed in choosing regional anaesthesia for knee arthroscopy, the lack of need for knee braces and knee medications, the of use of LMW heparin for thromboprophylaxis, 1-2 days of hospitalization, the recommendation of rehabilitation and the use of magnetic resonance as a diagnostic test for meniscus damage. Surgical expertise was significantly associated with the performance of meniscus suture procedures (p = 0.009). Experts recommended starting rehabilitation on the day of surgery (p=0.007) and were more likely to use objective physical tests (p=0.003). Non-expert surgeons recommended a longer period from meniscus suture to full-range knee motion (p=0.001) and admitted that patient age does matter for meniscus repair qualification (p=0.002).Conclusions: There is consensus among almost all issues of meniscus tear treatment in the environment of Polish orthopaedists; however, the issues of rehabilitation and the use of advanced meniscus repair techniques are associated with surgical expertise.
Influence of Severity of Infection on the Effect of Appropriate Antimicrobial Therapy for Acinetobacter baumannii Bacteremic Pneumonia
Authors: Kang Fang-Yu , How Chorng-Kuang , Wang Yung-Chih , Cheng Aristine , Yang Ya-Sung , Kuo Shu-Chen , Liu Chang-Pan , Liu Yuag-Meng , Chen Te-Li , Lee Yi-Tzu 
Published: September 2020

Abstract
Background The impact of appropriate antimicrobial therapy for A. baumannii bacteremic pneumonia has not been well established due to the inclusion of the three phenotypically indistinguishable Acinetobacter species and confounding factors including underlying diseases and severity of infection. This retrospective study aimed to evaluate the impact of appropriate antimicrobial therapy on 14-day mortality in A. baumannii bacteremic pneumonia patients after adjusting for risk factors. Methods This study was conducted at five medical centers in Taiwan between July 2012 and June 2016. A. baumannii species identification was performed using reference molecular methods. Risk factors for 14-day mortality were analyzed via logistic regression. The interaction between the Acute Physiology and Chronic Health Evaluation (APACHE) II score and appropriate antimicrobial therapy was assessed using the logistic model. Results A total of 336 patients with monomicrobial A. baumannii bacteremic pneumonia were included in this study. The overall 14-day mortality rate was 47.3%. The crude mortality of appropriate antimicrobial therapy was 35.9% (57 of 151 patients). Appropriate antimicrobial therapy was associated with a lower mortality after multivariate adjustment (odds ratio [OR], 0.57; 95% confidence interval [CI], 0.34-0.97; p = 0.04), and the effect was influenced by APACHE II score (OR for interaction term, 0.0098; 95% CI, 0.0005-0.1885; p = 0.002). Further analysis demonstrated that appropriate antimicrobial therapy significantly reduced 14-day mortality among the patients with an APACHE II score >35 (OR 0.0098; 95% CI 0.0005-0.1885). Conclusion Appropriate antimicrobial therapy decreases 14-day mortality of the most severely ill patients with A. baumannii bacteremic pneumonia.
Gastrointestinal symptoms and fecal nucleic acid testing of children with 2019 coronavirus disease: a systematic review and meta-analysis
Authors: Wang Ji-Gan , Cui Hairong , Tang Huabo , Deng Xiu-li 
Published: September 2020

Abstract
In order to understand the clinical manifestations and incidence of gastrointestinal symptoms of coronavirus disease (COVID-19) in children and discuss the importance of fecal nucleic acid testing.We retrospectively analyzed studies on gastrointestinal symptoms and fecal nucleic acid detection in pediatric COVID-19 patients from January 1, 2020 to August 10, 2020, including prospective clinical studies and case reports. The results of fecal nucleic acid detection were analyzed systematically. Stata12.0 software was used for meta-analysis.The results showed that the most common gastrointestinal symptoms in children with COVID-19 were vomiting and diarrhea, with a total incidence of 17.7% (95% Cl: 13.9%-21.5%). However, the prevalence of gastrointestinal symptoms in other countries (21.1%, 95% CI: 16.5%-25.7%) was higher compared to China (12.9%, 95% CI: 8%-17.7%). In Wuhan, the pooled prevalence was much higher (41.3%, 95 % CI: 3.2%-79.4%) compared to areas outside Wuhan in China (7.1%, 95 % CI: 4.0%-10.3%).The positive rate of fecal nucleic acid testing in COVID-19 children was relatively high at 85.8% (91/106). Additionally, 71.2% (52/73) were still positive for fecal nucleic acid after respiratory tract specimens turned negative. One and two weeks after the respiratory tract specimens turned nucleic acid-negative, 45.2% (33/73) and 34.2% (25/73) patients, respectively, remained fecal nucleic acid-positive. The longest interval between the respiratory tract specimens turning negative and fecal specimens turning negative exceeded 70 days.Conclusions and Relevance:Gastrointestinal symptoms in pediatric COVID-19 are relatively common. Attention should be paid to the detection of fecal nucleic acids in children. Fecal nucleic acid-negative status should be considered as one of the desegregation standards.
Analyses of the Local Control of Pulmonary Oligometastases after Stereotactic Body Radiotherapy and the Impact of Local Control on Survival
Authors: Yamamoto Takaya , Niibe Yuzuru , Aoki Masahiko , Shintani Takashi , Yamada Kazunari , Kobayashi Mitsuru , Yamashita Hideomi , Ozaki Masatoki , Manabe Yoshihiko , Onishi Hiroshi , Yahara Katsuya , Nishikawa Atsushi , Katsui Kuniaki , Oh Ryoong-Jin , Terahara Atsuro , Jingu Keiichi 
Published: September 2020

Abstract
Background: Successful local therapy for oligometastases may lead to longer survival. The purpose of this multicentre retrospective study was to investigate factors affecting the local control (LC) of pulmonary oligometastases treated by stereotactic body radiotherapy (SBRT) and to investigate the impact of LC on survival.Methods: The inclusion criteria included 1 to 5 metastases, the primary lesion and other extrathoracic metastases were controlled before SBRT, and the biological effective dose (BED10) of the SBRT was 75 Gy or more. The Cox proportional hazards model was used for analyses.Results: Data of 1378 patients with 1547 tumours from 68 institutions were analysed. The median follow-up period was 24.2 months. The one-year, 3-year and 5-year LC rates were 92.1%, 81.3% and 78.6%, respectively, and the 1-year, 3-year and 5-year overall survival rates were 90.1%, 60.3% and 45.5%, respectively. Multivariate analysis for LC showed that increased maximum tumour diameter (p=0.011), type A dose calculation algorithm (p=0.005), shorter overall treatment time of SBRT (p=0.035) and colorectal primary origin (p<0.001 excluding oesophagus origin) were significantly associated with a lower LC rate. In the survival analysis, local failure (p<0.001), worse performance status (1 vs. 0, p=0.013; 2–3 vs. 0, p<0.001), oesophageal primary origin (vs. colorectal origin, p=0.038), squamous cell carcinoma (vs. adenocarcinoma, p=0.006) and increased maximum tumour diameter (p<0.001) showed significant relationships with shorter survival.Conclusions: Several factors of oligometastases and SBRT affected LC. LC of pulmonary oligometastases by SBRT showed a significant survival benefit compared to patients with local failure.
Design and Optimization for UAV-Enabled Two-Way Relaying System with SWIPT
Authors: Wang Jinlong , Wang Gang , Chen Guanyi , Li Bo , Zhou Ruofei , Zhang Ruoyu 
Published: September 2020

Abstract
In this paper, we investigate the resource allocation scheme for an unmanned-aerial-vehicle-enable (UAV-enabled) two-way relaying system with simultaneous wireless information and power transfer (SWIPT), where two userequipment exchange information with the help of UAV relay and harvest energythrough power splitting (PS) scheme. Under the transmission power constraintsat UEs and UAV relay, a non-convex intractable optimization problem isformulated which maximizes the sum retained energy of two UEs while satisfying the minimum signal-to-noise ratio requirement. We decouple the complicated beamforming and PS factors optimization problem into three solvable subproblems and propose an efficient alternating optimization scheme. Subsequently, in order to reduce the complexity, a robust scheme based on generalized singular value decomposition (GSVD) is designed. Finally, numerical results verify the robustness and effectiveness of two proposed schemes.
Accessibility of Urban Green Infrastructure in Addis Ababa City, Ethiopia: Current Status and Future Challenge
Authors: Azagew Sileshi , Worku Hailu 
Published: September 2020

Abstract
Background: Many studies have been conducted on the challenges underpinning the depletion and inaccessibility of urban green infrastructures (UGI) in cities of developed countries. Contrary to this, similar studies in rapidly urbanizing cities of Africa are scant. In this study, we assessed the status, accessibility and constraints of UGI in rapidly urbanizing city Addis Ababa, Ethiopia. We first mapped and calculated the status of UGI from 2003 to 2016 based on the land use data in Arch GIS. We then analyzed UGI access such as recreational parks based on proximate and per capita green indicators by using the land use maps, road network and gridded population data. Finally, we examined the challenges behind the current states of UGI based on document review, expert interview and field observation.
Results: Our study disclosed that the land use of UGI from 2003 to 2016 is decreased by 9.2%. The land use of urban agriculture decreased significantly (by 11.9%) followed by urban forest (by 3.7%). The accessibility indicators also revealed that the city residents have no sufficient recreational UGI. The city’s park per capita was very small (0.37m 2 ) compared to Ethiopian UGI standards (15m 2 ) and the large portion of the city’s population (above 90%) has no access to existing parks within the minimum walking distance thresholds. Expansion of built up environment, density, weak implementation of policies and plans, and lack of priority for UGI development were identified as the major constraints behind the current state of UGI in the city.
Conclusion: we conclude that UGI is degrading and insufficiently accessible for the city residents due to weak enforcement of development plans, density, built up area expansion, and lack of priority for UGI. Thus, strict adherence to the development plans and regulations is of paramount importance to maintain UGI in the city. Moreover, developing small to median size parks in already proposed areas, new expansion and renewal parts of the city is vital to enhance recreational park access. We hope that this study serves as a benchmark for policy and planning to ensure accessible and adequate UGI in rapidly urbanizing city Addis Ababa and beyond.
Little Akaki River Sediment Enrichment with Heavy Metals, Pollution Load and Potential Ecological Risks in Downstream, Central Ethiopia
Authors: Mekuria Deshu Mamo , Kassegne Alemnew Berhanu Berhanu , Asfaw Seyoum Leta Leta 
Published: September 2020

Abstract
Background: Addis Ababa City’s river ecosystem is under extreme pressure as a result of inappropriate practices of dumping domestic and industrial wastes; thus, threatening its ability to maintain basic ecological, social and economic functions. Little Akaki River which drains through Addis Ababa City receives inorganic and organic pollutants from various anthropogenic sources. Most of inorganic pollutants such as toxic heavy metals released into the river are eventually adsorbed and settle in the sediment. The objective of this study was to evaluate the enrichment levels, pollution load and ecological risks of selected heavy metals (Zn, Cr, Cd and Pb) using various indices.Results: The mean concentrations of heavy metals in Little Akaki River sediment were: Zn (78.96 ± 0.021 - 235.2 ± 0.001mg/kg); Cr (2.19 ± 0.014 - 440.8 ± 0.003 mg/kg); Cd (2.09 ± 0.001-4.16 ± 0.0001mg/kg) and Pb (30.92 ± 0.018 -596.4 ± 0.066 mg/kg). Enrichment factor values indicated that sediments were moderate to significantly enriched with Zn and Cr; moderate to very highly enriched with Pb, and very highly enriched in all sampled sites with Cd. Geo-accumulation index and contamination factor values indicated that the sediments were moderate to very highly contaminated with toxic Cd and Pb. The decreasing order of pollution load index (PLI) in downstream was: (S9) > (S4) > (S8) > (S3)> (S6) > (S10) > (S5) > (S2)> (S7) > (S1). PLI and hierarchical cluster analysis revealed that the highest pollution load occurred in the lower course of the river (S9) which may be due to metals inputs from anthropogenic sources. The ecological risk (RI =350.62) suggested that the contaminated Little Akaki River sediment can pose considerable ecological risks of pollution.Conclusions: The concentrations of Zn, Cr, Cd and Pb in Little Akaki River sediment surpassed eco-toxicological guideline limits of USEPA (threshold effect concentration) and CCME (Interim Sediment Quality Guidelines). Thus, the contaminated sediments can pose adverse biological effects on sediment dwelling organisms.
A rare presentation of superficial, inter-muscular, cystic, extra-spinal schwannoma over upper back.
Authors: Saha Srinjoy 
Published: September 2020

Abstract
Schwannomas are rare tumours arising from peripheral nerve sheath and are usually related to the spinal cord and spinal nerves. Contrast magnetic resonance imaging (MRI) usually helps in establishing a pre-operative diagnosis. Rarely, their manifestation may be surprisingly new. Here, a 44-year-old lady came to our clinic with a painless asymptomatic progressively enlarging swelling over her upper back. It was fluctuant, with absent neural signs and symptoms. MRI showed a benign, purely-cystic, superficial-intermuscular, extra-spinal swelling near the upper thoracic vertebrae. However, classical diagnostic signs of schwannoma were absent. Complete surgical excision was performed with smooth dissection through a well-defined plane between the lesion and surrounding muscles. A 6.5x5.0x2.5 cm oval lesion with a glistening whitish-grey capsule was excised, and the deep wound was reconstructed in multiple layers. Interestingly, it was not attached to any identifiable nerves. Histopathology showed typical hallmarks like Antoni A regions and Verocay bodies. Positive S-100 staining during immunohistochemistry established its diagnosis as schwannoma. The postoperative one-and-half-year follow-up period was uneventful. Cystic schwannomas can surprise and confuse clinicians by arising anywhere in the body and with atypical manifestations. Surgeons need to consider it in the differential diagnoses of any undiagnosed slowly-growing swelling, including purely-cystic ones and perform careful surgical dissection to avoid any inadvertent nerve damage.
Genome-wide characterization and expression analysis&nbsp;of the heat shock transcription factor family&nbsp;in pumpkin&nbsp;(Cucurbita moschata)
Authors: Shen Changwei , Yuan Jingping 
Published: September 2020

Abstract
Background: Crop quality and yield are affected by abiotic and biotic stresses, and heat shock transcription factors (Hsfs) are considered to play important roles in regulating plant tolerance under various stresses. To investigate the response of Cucurbita moschata to abiotic stress, we analyzed the genome of C. moschata. Results: In this research, a total of 36 C. moschata Hsf (CmHsf) members were identified and classified into three subfamilies (I, II, and III) according to their amino acid sequence identity. The Hsfs of the same subfamily usually exhibit a similar gene structure (intron-exon distribution) and conserved domains (DNA-binding and other functional domains). Chromosome localization analysis showed that the 36 CmHsfs were unevenly distributed on 18 of the 21 chromosomes (except for Cm_Chr00, Cm_Chr08 and Cm_Chr20), among which 18 genes formed 9 duplicated gene pairs that have undergone segmental duplication events. The Ka/Ks ratio showed that the duplicated CmHsfs have mainly experienced strong purifying selection. High-level synteny was observed between C. moschata and other Cucurbitaceae species. Conclusions: The expression profile of CmHsfs in the roots, stems, cotyledons and true leaves revealed that the CmHsfs exhibit tissue specificity. The analysis of cis-acting elements and quantitative real-time polymerase chain reaction (qRT-PCR) revealed that some key CmHsfs were activated by cold stress, heat stress, hormones and salicylic acid. This study lays the foundation for revealing the role of CmHsfs in resistance to various stresses, which is of great significance for the selection of stress-tolerant C. moschata.