bluuebunny/crossref_metadata_2025_split huggingface dataset:
Losing sleep? The effects of exposure to shootings near one’s residence on self-reported sleep quantity in Chicago, 2020-2021
Authors: McLone Suzanne , Coleman Chad , Matzke Hannah , Fox Matthew , Jay Jonathan 
Published: February 2025

Abstract
Firearm violence is a public health crisis in the US and negatively impacts individuals and communities. We used data from The Healthy Chicago Survey, a citywide survey of 8,754 respondents from 2020-2021, and police-reported shootings to estimate the effect of residential exposure to shootings on sleep duration. Exposure was measured as fatal or non-fatal shootings occurring within 400 meters of the respondent’s residence, within 7 days before taking the survey. Sleep was categorized into &lt;6, 6-&lt;7, 7-&lt;9, and &gt;=9 hours/day. We used log-binomial regression models to estimate risk ratios (RR). We used probabilistic quantitative bias analysis to estimate the magnitude and direction of the impact of differential outcome misclassification of self-reported sleep on results. Of 8584 survey respondents, 589 (6.9%) were exposed to at least one shooting. The estimated associations between shootings and very short and moderately short sleep duration were null, while the RR for long sleep duration was 1.10 (95% confidence interval: 1.00, 1.22); results of the quantitative bias analysis for long sleep duration were null (RR=1.04 [95% simulation interval: 0.92, 1.15]). Our findings suggest that simply living close to a recent shooting may not affect sleep duration among adults living in Chicago, but further investigation is warranted.
Postoperative Outcomes in Body Contouring Procedures Following GLP-1 Receptor Agonist Use: A 10-Year Analysis
Authors: Liang Joey , Pillai Tara , Chopra Sakshi , Cathey Jackson M , Patel Ash 
Published: February 2025

Abstract

Background
Utilization of GLP-1 receptor agonists (GLP-1ras) has increased dramatically in recent years. While GLP-1ras appear safe to use overall, it remains unclear if pre-operative GLP-1ra use impacts body contouring surgery outcomes.

Objectives
This study evaluated the post-operative course of patients receiving body contouring procedures by GLP-1ra use.

Methods
This retrospective cohort study examined patients who received panniculectomies, brachioplasties, thighplasties, and abdominoplasties at a large academic institution between November 2014 and November 2024. Propensity score matched analysis paired cohorts by age, smoking status, and body mass index and hemoglobin A1c at the time of surgery. Univariate analyses and multivariable logistic regression were performed.

Results
In total, 590 patients were included in this study. Of these, 100 patients utilized GLP-1ras before surgery. Propensity score matched analysis paired 72 GLP-1ra and 143 non-GLP-1ra patients. 30-day readmissions and emergency department visits in matched and unmatched cohorts were similar by GLP-1ra use (p &gt; 0.05). Post-operative cellulitis occurred less frequently among GLP-1ra users in matched cohorts (p = 0.008); however, GLP-1ra use did not predict cellulitis on multivariable logistic regression. Duration of GLP-1ra use and timing of discontinuation prior to surgery did not predict the incidence of wound dehiscence, seromas, or hematomas. Patients using GLP-1ras for obesity had lower rates of wound dehiscence than patients using GLP-1ras for diabetes (p = 0.028).

Conclusions
Compared to non-GLP-1ra controls, GLP-1ra users have similar post-operative outcomes following body contouring surgery. Wound dehiscence is more prevalent among patients taking GLP-1ras for diabetes compared to weight loss, potentially due to worse glycemic control or associated comorbidities.
SATINN v2: automated image analysis for mouse testis histology with multi-laboratory data integration
Authors: Yang Ran , Celino-Brady Fritzie T , Dunleavy Jessica E M , Vigh-Conrad Katinka A , Atkins Georgia Rae , Hvasta Rachel L , Pombar Christopher R X , Yatsenko Alexander N , Orwig Kyle E , O’Bryan Moira K , Lima Ana C , Conrad Donald F 
Published: February 2025

Abstract
Analysis of testis histology is fundamental to the study of male fertility, but it is a slow task with a high skill threshold. Here, we describe new neural network models for the automated classification of cell types and tubule stages from whole-slide brightfield images of mouse testis. The cell type classifier recognizes 14 cell types, including multiple steps of meiosis I prophase, with an external validation accuracy of 96%. The tubule stage classifier distinguishes all 12 canonical tubule stages with external validation accuracy of 63%, which increases to 96% when allowing for ±1 stage tolerance. We addressed generalizability of SATINN, through extensive training diversification and testing on external (non-training population) wildtype and mutant datasets. This allowed us to use SATINN to successfully process data generated in multiple laboratories. We used SATINN to analyze testis images from 8 different mutant lines, generated from 3 different labs with a range of tissue processing protocols. Finally, we show that it is possible to use SATINN output to cluster histology images in latent space, which, when applied to the 8 mutant lines, reveals known relationships in their pathology. This work represents significant progress towards a tool for robust, automated testis histopathology that can be used by multiple labs.
A Systematic Review and Meta-Analysis Comparing the 2019 and 2005 Bosniak Classification Systems for Assessing Renal Cysts and Cystic Renal Masses: Diagnostic Accuracy and Inter-rater Agreement Evaluation
Authors: Niknejad Mohammad Taghi , Mohajeri Shiva , Javadrashid Reza , Shahir Eftekhar Mohammad , shojaeshafiei Farzaneh , Baradaran Mansoureh , Hatami Bahareh , Klontzas Michail E , Shahidi Ramin 
Published: February 2025

Abstract

Objectives
The Bosniak Classification System (BCS) is integral in clinical decision-making for Renal cysts and cystic renal masses, with updates in 2005 and 2019 aiming to enhance diagnostic accuracy and clinical utility. Despite these revisions, challenges in inter-rater agreement and practical applicability persist, underscoring the need for comprehensive evaluation of both versions' effectiveness in guiding patient care.

Methods
This meta-analysis adhered to PRISMA guidelines and systematically reviewed studies comparing the 2005 and 2019 BCS versions using CT or MRI. We searched PubMed, Embase, Scopus, and Web of Science, and used QUADAS-2 for quality assessment. In this study, we focused on diagnostic performance and inter-observer agreement. Statistical analysis involved bivariate random-effects modeling and assessing pooled sensitivity, specificity, and inter-rater reliability.

Results
We included eleven articles. The 2019 Bosniak classification showed higher diagnostic performance for CT (sensitivity: 85.7%, specificity: 81.9%) and MRI (sensitivity: 96.2%, specificity: 70.9%) compared to the 2005 version. Inter-rater reliability was better with the 2019 classification (CT kappa: 0.813, MRI kappa: 0.601) than with the 2005 version. The quality assessment indicated low risk of bias overall, though some studies had high risk in specific areas.

Conclusion
The Bosniak 2019 classification provides improved diagnostic specificity and inter-rater reliability compared to the 2005 version. Its adoption may enhance clinical decision-making and reduce overtreatment in managing cystic renal masses.

Advances in knowledge
This paper is novel in being the first meta-analysis to demonstrate that the Bosniak 2019 classification system significantly enhances inter-rater agreement, and overall diagnostic performance compared to the 2005 version, particularly in CT imaging, thus offering a more accurate and reliable tool for evaluating cystic renal masses.
Putting Countries on the Map? Pastoral Visits of John Paul II and International Trade
Authors: Popov Alexander 
Published: February 2025

Abstract
During his Pontificate from 1979 until 2005, Pope John Paul II visited 130 countries, more than the 263 Popes before him combined. I document a significant increase in exports to trading partners with a relatively high share of Catholics following a Pastoral visit, leading to a non-negligible increase in aggregate exports. The biggest beneficiaries in terms of increased trade are visited countries that are at lower stages of economic development and have relatively fewer Catholics and relatively weaker trade links. The effect is absent for other prominent episodes, such as visits by celebrated secular leaders or global sports events.
Optimal timing of thoracic endovascular aortic repair for subacute and chronic type B aortic dissection: insights from the Tokushukai medical database
Authors: Ueki Chikara , Uchida Naomichi , Ohashi Takeki , Higashiue Shinichi 
Published: February 2025

Abstract

OBJECTIVES
This study aimed to evaluate the impact of intervention timing on thoracic aortic remodelling following thoracic endovascular aortic repair (TEVAR) for subacute and chronic type B aortic dissection (TBAD).

METHODS
The study included 110 patients undergoing TEVAR for TBAD at least 2 weeks after onset, sourced from the Tokushukai Medical Database. The primary outcome was complete thoracic aortic remodelling (CTR) at 1 year, defined as thoracic false lumen thrombosis and a false lumen diameter &lt; 10 mm up to the level of Th10.

RESULTS
The 1-year CTR rate was 67.3%. CTR was strongly associated with intervention timing: 88.4% (≤3 months: n = 69), 57.1% (3–12 months: n = 14), and 18.5% (≥12 months: n = 27). Receiver operating characteristic (ROC) curve analysis confirmed a 3-month cutoff for achieving CTR (area under the curve 0.857). Multivariable analysis identified interval from onset to TEVAR &gt;3 months (odds ratio [OR] 9.75, 95% confidence interval [CI] 2.86–33.28) and initial thoracic false lumen diameter (OR 1.13, 95% CI 1.02–1.27) as independent predictors of CTR failure. Similar trends were observed in the DeBakey IIIb subgroup, with a 3-month cutoff for achieving CTR and interval from onset to TEVAR &gt;3 months (OR 16.38, 95% CI 3.54–75.83), initial thoracic false lumen diameter (OR 1.25, 95% CI 1.00–1.54) and initial abdominal aortic diameters (OR 1.14, 95% CI 1.01–1.29) predicting CTR failure.

CONCLUSIONS
Early TEVAR within 3 months of onset is crucial for achieving complete aortic remodelling in TBAD. Therefore, early preventive TEVAR in eligible patients is recommended to optimize outcomes
Application of transcriptomics concentration-response modeling for prioritization of contaminants detected in tributaries of the North American Great Lakes
Authors: Cavallin Jenna E , Bush Kendra , Corsi Steve , DeCicco Laura , Flynn Kevin , Kasparek Alex , Hazemi Monique , Maloney Erin , Schumann Peter , Villeneuve Daniel L 
Published: February 2025

Abstract
As part of the Great Lakes Restoration Initiative, chemical monitoring and surveillance efforts have detected ∼330 chemicals in surface water of Great Lakes tributaries. There were 140 chemicals for which no empirical toxicity data were available. The aim of the present study was to generate transcriptomic points of departure (tPODs) for 10 of these compounds and demonstrate how they could be applied in a screening-level prioritization. Organisms representing three trophic levels of the aquatic food-web (P. promelas, D. magna, and R. subcapitata) were exposed for 24 h to a ½-log dilution series of nominal exposure concentrations typically ranging from 66.7 to 0.021 µM of each chemical. In addition to observations of apical effects (e.g., survival and morphology), whole body transcriptomic responses (tPODs) to each chemical were evaluated with targeted analysis using TempO-seq for P. promelas and D. magna and non-targeted RNA-seq for R. subcapitata. The tPODs ranged from 0.18 to 10.8 µM for P. promelas and 0.32 to 29 µM for D. magna, with the most potent of the chemicals tested being fipronil carboxamide for both species. For R. subcapitata, the tPODs ranged from 0.04 to 1.77 µM, with gabapentin as the most potent chemical tested. Empirically derived tPODs from these data-poor chemicals were compared to concentrations detected in the Great Lakes basin. Environmental concentrations were less than the tPODs, except for R. subcapitata and 3,4-dichlorophenyl isocyanate. Similarly, tPODs from previously tested data-rich chemicals were compared with environmental concentrations, in which case tPODs from several chemicals overlapped environmental concentrations. This work demonstrates the potential utility of emerging ecological high-throughput transcriptomics assays to support screening and prioritization of data-poor environmental contaminants.
Translational modeling of BTZ-043 in predicting phase IIA efficacy and evaluating drug-drug interactions with BPaL in murine models
Authors: Ngara Bernard , Flori Lorenzo , van Wijk Rob Christiaan , Ernest Jacqueline P , Tyagi Sandeep , Soni Heena , Hölscher Christoph , Walter Kerstin , Dreisbach Julia , Hoelscher Michael , Nuermberger Eric L , Savic Rada 
Published: February 2025

Abstract

Introduction
BTZ-043 is a promising novel drug candidate for anti-tuberculosis treatment. This study aimed to apply a previously developed mouse-to-human translational modeling platform for anti-tuberculosis drugs to predict phase IIA outcomes for BTZ-043 in humans and evaluate the impact of observed drug-drug interactions on the contribution of BTZ-043 to combotherapy in a mouse model.

Methods
The study utilized data from mouse experiments for BTZ-043 monotherapy and combotherapy with bedaquiline, pretomanid, and linezolid, and clinical information for BTZ-043 monotherapy. The translational models were applied to predict the colony-forming units as a measure of efficacy in humans treated with BTZ-043 monotherapy and evaluate the effect of BTZ-043 on the pharmacokinetics-pharmacodynamics of combotherapy bedaquiline, pretomanid, and linezolid.

Results
The mouse-pharmacokinetic and mouse-pharmacodynamic data for BTZ-043 monotherapy were best described by two-compartmental and direct Emax models, respectively. The model-based prediction of efficacy in humans was comparable to the observed phase IIA efficacy. Single-compartmental models, developed separately, best described the mouse-pharmacokinetic data for bedaquiline, pretomanid, and linezolid in combotherapy. Co-administration with BTZ-043 was associated with at least a 2-fold reduction in bedaquiline, pretomanid, and linezolid exposures in mice, and model-based simulations suggested that the observed decreases in exposure to these drugs would have resulted in even lower efficacy than what was observed when BPaL is co-administered with BTZ-043.

Conclusion
The translational modeling platform adequately predicted the efficacy of BTZ-043 monotherapy. In the absence of drug-drug interactions, co-administration of BTZ-043 with bedaquiline, pretomanid, and linezolid in combotherapy is predicted to improve treatment efficacy.
Resolving ecological drivers of temporal variations of β-diversity across intertidal microbiomes
Authors: Liu Xia , Gong Xiaofan , Ma Kai , Song Wen , Zhou Jiayin , Wang Mengqi , Li Yueyue , Ji Mengzhi , Li Yan , Han He , Wang Yuzhuo , Tu Qichao 
Published: February 2025

Abstract
Resolving the ecological drivers mediating the diversity patterns of microbial communities across space and through time is a central issue in microbial ecology. Both regional species pools and local community assembly contribute to the spatial turnover of biodiversity. In this study, we extended the concept of regional species pool to temporal, and investigated the seasonal dynamics of intertidal microbiomes across four microbial domains (bacteria, archaea, fungi, and protists). The results showed that the seasonal variations of microbial β-diversity were primarily governed by community assembly processes rather than temporal species pools. Different microbial domains were structured by different ecological processes, with homogeneous selection as the major process for all microbial domains. Additionally, bacteria and fungi were critically shaped by drift, and protists by drift and homogeneous dispersal. Among various factors, temperature was important in shaping the temporal patterns of microbial β-diversity. The fluctuation in temperature was strongly associated with fungi and protists, resulting in high drift of community composition. This study demonstrated that community assembly processes governed the dynamic seasonal β-variations of intertidal microbiomes, expanding our understanding from spatial ecology.
The Lumen Prize 2024
Authors: Smith Georgia 
Published: February 2025

Abstract
The Lumen Prize celebrates art created with technology, and the BCS Award highlights works that explore the intersection of computing, art and society. Keiken, an artist collective co-founded by Tanya Cruz, Hana Omori and Isabel Ramos in 2015, won the 2024 BCS Award at the Lumen Prize for their immersive installation, Spirit Systems of Soft Knowing.
How many truck drivers would have sleep disorders? : Investigation on lifestyle and stress on insomnia among Japanese male truck drivers
Authors: Aoki Ryoya , Miyachi Takashi , Sugano Yuta , Kanke Choichiro , Yamazaki Teiichiro , Mishima Kazuo , Nomura Kyoko 
Published: February 2025

Abstract
Objectives: This study aimed to investigate how many drivers would have sleep disorders and what factors would be most associated with chronic insomnia symptoms.
Methods: A cross-sectional study of 505 truck drivers in Akita prefecture was conducted using a self-administered questionnaire and health checkup data. We defined insomnia based on the International Classification of Sleep Disorders, 3rd edition (ICSD-3), sleep apnea syndrome (SAS) with a simple four-variable screening tool, and restless legs syndrome (RLS) with RLS/Willis-Ekbom disease diagnostic criteria. Investigated factors included sleep duration, driving characteristics, caffeine types (foods and beverage) and amounts, caffeine intake timing, state-trait anxiety inventory (STAI), individual stress, and other covariates.
Results: The prevalence of suspected SAS was 23.2% (n = 154), and that of RLS was 0.8% (n = 5). After excluding those, chronic insomnia symptoms were present in 36/505 drivers (7.1%). After adjusting for covariates, a logistic model demonstrated that drinking habits (Odds ratio, OR 6.21, 95% Confidence Interval, CI:1.07–35.8), caffeine intake before sleep (OR 2.65, 95% CI:1.09–6.45), sleep duration on days off (OR 1.44, 95% CI: 1.01–2.05), and STAI score (OR 12.8, 95% CI: 2.53–64.2) were significantly associated with chronic insomnia symptoms. STAI was significantly positively correlated with individual stress, such as family worries (r = 0.22), relationships with non-partners (r = 0.28), and health (r = 0.23).
Conclusions: Our study revealed that one fourth of male truck drivers had sleep disorders that require further medical evaluation. For male truck drivers, a lifestyle modification and stress relief may be a key to address insomnia.
Incarcerated peri-inguinal hernia containing the appendix: a case report
Authors: Baumkirchner Julian M , Aydin Mustafa , Simoes de Almeida Sema , Zünd Michael 
Published: February 2025

Abstract
Primary ventral hernia (PVH) is a main differential diagnosis of abdominal wall masses and typically occurs at areas of structural weakness, such as the linea alba. This report draws attention to atypical PVHs of the peri-inguinal region, an underdiagnosed subgroup of defects located adjacent to the inguinal canal and below the semilunar line. The absence of a standardized definition or classification complicates the diagnosis of this infrequent pathology. We present a case of a patient with a tender abdominal wall mass, initially interpreted as superinfected hematoma. Despite drainage, the patient’s physical condition continued to deteriorate. Repeat imaging eventually revealed acute appendicitis inside a peri-inguinal hernia. Laparoscopic appendectomy was performed, and the abscess cavity was incised, debrided and left open, which led to successful secondary closure of the wound. This case highlights the need for greater awareness of atypical hernias and their potential complications to enable timely detection and adequate treatment.
Investigating the effects of fresh gas on the Active Galactic Nuclei luminosity of early- and late-type galaxies
Authors: Winiarska Martyna W , Raimundo Sandra I , Davis Timothy A , Riffel Rogério , Shankar Francesco , Wiseman Phil 
Published: February 2025

Abstract
The main fuelling processes for Active Galactic Nuclei (AGN) are currently unknown. Previous work showed that galaxies with a large kinematic misalignment between their stellar and gas reservoirs have a higher AGN fraction than galaxies without misalignment. Such misalignment is a strong indication of a past galaxy interaction or an external accretion event. In this work we use integral field spectroscopy data from the SAMI and MaNGA surveys to investigate the AGN luminosity as a function of kinematic misalignment angle. Our sample of AGN exhibit bolometric luminosities in the range 1040 to 1043 erg s−1, indicative of low to moderate luminosity AGN. We find no correlation between AGN luminosity as a function of misalignment for AGN host galaxies from both surveys. We find some differences between the AGN luminosity of early- and late-type AGN host galaxies (ETGs, LTGs). AGN in LTG hosts have a wider luminosity range, with most LTG hosts showing aligned stellar to gas kinematics. AGN in ETG hosts have a luminosity range that does not depend on misalignment angle, suggesting AGN in ETG hosts are consistent with being fuelled by external accretion events, irrespective of their stellar to gas kinematic misalignment. While all the AGN in ETGs in our sample are consistent with being activated and fuelled by external gas, the range of observed AGN luminosities is likely caused by secondary factors such as the amount of fresh gas brought into the galaxy by the external interaction.
Mastering the Art of Independent Surgery: 10 Tips for Solo Surgeons in Reconstructive Microsurgery
Authors: Chang Chad , Berner Juan Enrique , Astolfi Martina , Di Meglio Filippo , Sorkin Alex , Chen Hung-Chi , Marcasciano Marco 
Published: February 2025

Summary:
The increasing necessity for solo surgery in plastic and reconstructive microsurgery is driven by contemporary challenges such as a growing and aging population, a shortage of qualified assistants, and the ongoing recovery efforts from COVID-19. Historically limited to remote or exceptional circumstances, solo surgery is now more frequently performed due to these evolving factors. Technological advancements, including robotics, play a crucial role in facilitating this transition and supporting the trend toward self-sufficiency in surgical practice. This article presents practical strategies for executing solo surgery based on our team’s experience and a review of current literature. Key considerations discussed include patient positioning and optimizing surgical workflows. By presenting these recommendations and techniques, derived from both practical experience and literature, we highlight that plastic surgeons and microsurgeons can maintain consistently high standards of surgical care, even when operating independently.