bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new constraint programming model and solving for the cyclic hoist scheduling problem
Authors: Wallace Mark , Yorke-Smith Neil 
Published: November 2020

AbstractThe cyclic hoist scheduling problem (CHSP) is a well-studied optimisation problem due to its importance in industry. Despite the wide range of solving techniques applied to the CHSP and its variants, the models have remained complicated and inflexible, or have failed to scale up with larger problem instances. This article re-examines modelling of the CHSP and proposes a new simple, flexible constraint programming formulation. We compare current state-of-the-art solving technologies on this formulation, and show that modelling in a high-level constraint language, MiniZinc, leads to both a simple, generic model and to computational results that outperform the state of the art. We further demonstrate that combining integer programming and lazy clause generation, using the multiple cores of modern processors, has potential to improve over either solving approach alone.
Chemical and structural properties of reduced graphene oxide—dependence on the reducing agent
Authors: Lesiak B. , Trykowski G. , Tóth J. , Biniak S. , Kövér L. , Rangam N. , Stobinski L. , Malolepszy A. 
Published: November 2020

AbstractGraphene oxide (GO) prepared from graphite powder using a modified Hummers method and reduced graphene oxide (rGO) obtained from GO using different reductants, i.e., sodium borohydride, hydrazine, formaldehyde, sodium hydroxide and L-ascorbic acid, were investigated using transmission electron microscopy, X-ray diffraction, Raman, infrared and electron spectroscopic methods. The GO and rGOs’ stacking nanostructure (flake) size (height x diameter), interlayer distance, average number of layers, distance between defects, elementary composition, content of oxygen groups, C sp3 and vacancy defects were determined. Different reductants applied to GO led to modification of carbon to oxygen ratio, carbon lattice (vacancy) and C sp3 defects with various in-depth distribution of C sp3 due to oxygen group reduction proceeding as competing processes at different rates between interstitial layers and in planes. The reduction using sodium borohydride and hydrazine in contrary to other reductants results in a larger content of vacancy defects than in GO. The thinnest flakes rGO obtained using sodium borohydride reductant exhibits the largest content of vacancy, C sp3 defects and hydroxyl group accompanied by the smallest content of epoxy, carboxyl and carbonyl groups due to a mechanism of carbonyl and carboxyl group reduction to hydroxyl groups. This rGO similar diameter to GO seems to result from a predominant reduction rate between the interstitial layers. The thicker flakes of a smaller diameter than in GO are obtained in rGOs prepared using remaining reductants and result from a higher rate of reduction of in plane defects.
Fermions Meet Two Bosons—the Heteronuclear Efimov Effect Revisited
Authors: Tran Binh , Rautenberg Michael , Gerken Manuel , Lippi Eleonora , Zhu Bing , Ulmanis Juris , Drescher Moritz , Salmhofer Manfred , Enss Tilman , Weidemüller Matthias 
Published: November 2020

AbstractIn this article, we revisit the heteronuclear Efimov effect in a Bose-Fermi mixture with large mass difference in the Born-Oppenheimer picture. As a specific example, we consider the combination of bosonic 133Cs and fermionic 6Li. In a system consisting of two heavy bosons and one light fermion, the fermion-mediated potential between the two heavy bosons gives rise to an infinite series of three-body bound states. The intraspecies scattering length determines the three-body parameter and the scaling factor between consecutive Efimov states. In a second scenario, we replace the single fermion by an entire Fermi Sea at zero temperature. The emerging interaction potential for the two bosons exhibits long-range oscillations leading to a weakening of the binding and a breakup of the infinite series of Efimov states. In this scenario, the binding energies follow a modified Efimov scaling law incorporating the Fermi momentum. The scaling factor between deeply bound states is governed by the intraspecies interaction, analogous to the Efimov states in vacuum.
Backlash Against Globalisation and the Shadow of Phobos
Authors: Rewizorski Marek 
Published: November 2020

AbstractThis article addresses challenges to the established international order. Its critique becomes particularly discernible at the domestic level, where political and economic frameworks are contested by electorates and anti-establishment movements in Western countries, engulfed by anti-globalisation sentiments and disillusioned with the asymmetric formula of globalisation. Populism implies that the ‘social revolt’ facing the West today, regardless of whether it takes place in France, Greece, Hungary, Poland, the UK or the USA, is not a legitimate response to deep-seated problems but rather is the problem itself. The main aims of this article are to investigate what has caused this surge of support for populism in the West; what the role of the default system of economic governance is in inspiring populist resentment; and, finally, what the identity crisis, stemming from ‘hyperglobalisation’, and wrecking the social order in Western societies has to do with fear, (un)fairness and the redistributive effects of economic globalisation.
Art in Corporate Governance: a Deweyan Perspective on Board Experience
Authors: Nordberg Donald 
Published: November 2020

AbstractCorporate governance sits at the intersection of many disciplines, among them law, business, management, finance, and accounting. The point of departure for large portions of this literature concerns the ugliness of greed, ambition, misdemeanors, and malfeasance of corporations, their directors, and those actors who hold shares in them. This essay takes a rather different starting point. Drawing upon insights from a distant field, it uses the discussion of aesthetics in Dewey’s treatise on art to ask what motivates directors to act in ways that constitute the attention and engagement that we associate with the effectiveness of boards. Using Dewey’s thinking about aesthetic experience, this paper examines the experience of organization boards, both in the literature and in the personal experience of the author. These observations point to need to reflect on motivation when considering both the practice of corporate governance and the policy frameworks in which it operates.
The threat of thinking in threats: reframing global health during and after COVID-19
Authors: Sondermann Elena , Ulbert Cornelia 
Published: November 2020

AbstractNarratives and metaphors shape how actors perceive the world around them and how policymakers frame the range of policy choices they think of as feasible. The metaphor of war and the narrative of how to tackle the unprecedented threat of COVID-19 are effective mechanisms to convey urgency. However, they also bear serious implications: Thinking in terms of health threats works with a logic of exceptionalism, which supports images of “us” vs. an “enemy” thereby shortening complex lines of causality and responsibility and privileging national answers. It fails to provide for a normative framework for drafting long-term systemic approaches. In this contribution, we critically engage with existing narratives of global health security and show how the logic of exceptionalism is limiting the current responses to the pandemic. We conceptualize an alternative narrative that is based on the logic of solidarity and argue that within this alternative framing a more sustainable and ultimately more just way of coping with infectious diseases will be possible.
Identifying Anticipated Events of Future Clinical Trials by Leveraging Data from the Placebo Arms of Completed Trials
Authors: Tan Xiang-Lin , Kern David M. , Cepeda M. Soledad 
Published: November 2020

Abstract
Background
An important component of a systematic strategy for safety surveillance is prospective identification of anticipated serious adverse events (SAEs). Developing a structured approach to identify anticipated events and estimating their incidence can help align the safety strategy and the safety surveillance efforts.

Methods
We developed a novel approach to identify anticipated events for a hypothetical randomized, double-blind, controlled trial in subjects with bipolar disorder using the adverse events reported in the placebo arm of trials from the ClinicalTrials.gov database. We searched the ClinicalTrials.gov database for all trials on bipolar depression with similar inclusion/exclusion criteria and study duration as our hypothetical study. The frequencies of anticipated events in placebo arms were abstracted from each trial and 95% confidence intervals (CI) were calculated using the Clopper–Pearson method. Meta-analysis with a random effects model was performed to obtain a summary estimate and 95% CI for the events identified in more than one trial.

Results
A total of 129 clinical trials were initially identified, and 18 were ultimately selected as they met all the selection criteria. There were 69 unique anticipated SAEs identified, and 13 out of 69 were reported in at least 2 clinical trials. The top 5 anticipated SAEs for our study were: (1) hospitalization, psychiatric symptom (3.57%); (2) suicidal behavior, overdose (3.57%), (3) cholecystitis (2.86%); (4) fall (2.86%); (5) road traffic accident, injury (2.86%).

Conclusion
We successfully identified the anticipated events from registered trials that included a population similar to our trial. This method for identifying anticipated events could be applied to other disease areas.
Prediction of depression symptoms in individual subjects with face and eye movement tracking
Authors: Stolicyn Aleks , Steele J. Douglas , Seriès Peggy 
Published: November 2020

AbstractBackgroundDepression is a challenge to diagnose reliably and the current gold standard for trials of DSM-5 has been in agreement between two or more medical specialists. Research studies aiming to objectively predict depression have typically used brain scanning. Less expensive methods from cognitive neuroscience may allow quicker and more reliable diagnoses, and contribute to reducing the costs of managing the condition. In the current study we aimed to develop a novel inexpensive system for detecting elevated symptoms of depression based on tracking face and eye movements during the performance of cognitive tasks.MethodsIn total, 75 participants performed two novel cognitive tasks with verbal affective distraction elements while their face and eye movements were recorded using inexpensive cameras. Data from 48 participants (mean age 25.5 years, standard deviation of 6.1 years, 25 with elevated symptoms of depression) passed quality control and were included in a case-control classification analysis with machine learning.ResultsClassification accuracy using cross-validation (within-study replication) reached 79% (sensitivity 76%, specificity 82%), when face and eye movement measures were combined. Symptomatic participants were characterised by less intense mouth and eyelid movements during different stages of the two tasks, and by differences in frequencies and durations of fixations on affectively salient distraction words.ConclusionsElevated symptoms of depression can be detected with face and eye movement tracking during the cognitive performance, with a close to clinically-relevant accuracy (~80%). Future studies should validate these results in larger samples and in clinical populations.
Spontaneous regression of Markel cell carcinoma in anterior mediastinum without cutaneous involvement
Authors: Nguyen My-Lien , Melton M. Kole , Ahmad Salahuddin , Henson Christina 
Published: November 2020

AbstractBackground:Merkel cell carcinoma (MCC) is a rare and highly aggressive neuroendocrine malignancy typically involving the skin. The majority of MCC involves the head/neck region and the extremities. Despite the aggressive nature of the disease, there have been several case studies that report spontaneous regression. We report a unique case of spontaneous regression of an MCC in a peculiar region in the anterior mediastinum with no cutaneous involvement.Methods:A 50-year-old man who presented with a mobile low anterior neck mass, proven by biopsy, to be MCC. Subsequent PET/CT confirmed an FDG (Flurodeoxyglucose)-avid upper mediastinal mass. The mass gradually regressed over the course of 1 month subsequent to biopsy and was no longer palpable on exam or visible on subsequent CT scans. The patient was treated with intensity modulated radiation therapy with a total dose of 6,160 cGy in 28 fractions to the site of previously visible primary disease. At-risk nodal basins were also treated. On subsequent follow-up, the patient continued to have no clinical or radiographic signs of disease.Discussion:Spontaneous regression of an MCC is rare but has been reported mostly in the head/neck region following biopsy. It is unknown why spontaneous regression occurs. There is a possibility that biopsy may stimulate T-lymphocytes resulting in spontaneous regression.Conclusion:This is the first case to our knowledge of spontaneous regression of an MCC in the anterior mediastinum with no cutaneous involvement. Most MCC are seen clinically due to skin changes with a majority of cases occurring in the head/neck region.
Planar suspended line technique based UWB-MIMO antenna having dual-band notching characteristics
Authors: Vyas Kirti , Yadav Rajendra Prasad 
Published: November 2020

AbstractThis communication reports significant isolation improvement utilizing planar suspended line (PSL) technique in ultra wideband (UWB) antenna for Multiple Input Multiple Output (MIMO) application. The antenna exhibits dual-band notched characteristic in Wireless Local Area Network (WLAN) band covering 5.45–5.85 GHz range; and in 7.15–7.95 GHz range for X-band downlink operations in satellite communication. Band-notching characteristics have been obtained by employing a single Elliptical Split Ring Resonator (ESSR) placed adjacent to each microstrip feed line of the radiating element and duo of “Y”-shaped strips employed within the circular ring of individual radiating elements. Two elements antenna occupy a compact space of 20 × 36 × 1.6 mm3 exhibiting huge measured impedance bandwidth (S11/S22 < −10 dB) covering 3.1–11.5 GHz and significant isolation of >21 dB in the almost entire band of operation. The electrical performance of antennas has been analyzed in terms of various MIMO parameters. Measured results demonstrate good accord with simulated results proving the competency of proposed antenna in high-density package systems and massive MIMO applications.
CaMuS: simultaneous fitting and de novo imputation of cancer mutational signature
Authors: Cartolano Maria , Abedpour Nima , Achter Viktor , Yang Tsun-Po , Ackermann Sandra , Fischer Matthias , Peifer Martin 
Published: November 2020

AbstractThe identification of the mutational processes operating in tumour cells has implications for cancer diagnosis and therapy. These processes leave mutational patterns on the cancer genomes, which are referred to as mutational signatures. Recently, 81 mutational signatures have been inferred using computational algorithms on sequencing data of 23,879 samples. However, these published signatures may not always offer a comprehensive view on the biological processes underlying tumour types that are not included or underrepresented in the reference studies. To circumvent this problem, we designed CaMuS (Cancer Mutational Signatures) to construct de novo signatures while simultaneously fitting publicly available mutational signatures. Furthermore, we propose to estimate signature similarity by comparing probability distributions using the Hellinger distance. We applied CaMuS to infer signatures of mutational processes in poorly studied cancer types. We used whole genome sequencing data of 56 neuroblastoma, thus providing evidence for the versatility of CaMuS. Using simulated data, we compared the performance of CaMuS to sigfit, a recently developed algorithm with comparable inference functionalities. CaMuS and sigfit reconstructed the simulated datasets with similar accuracy; however two main features may argue for CaMuS over sigfit: (i) superior computational performance and (ii) a reliable parameter selection method to avoid spurious signatures.
Platelet PD-L1 suppresses anti-cancer immune cell activity in PD-L1 negative tumors
Authors: Zaslavsky Alexander B. , Adams M. P. , Cao X. , Maj T. , Choi J. E. , Stangl-Kremser J. , Patel S. , Putelo A. , Lee S. K. , Nallandhighal S. , Kasputis A. , Alva A. , Lew M. , Qin A. , Mehra R. , Morgan T. M. , Salami S. S. , Reichert Z. , Udager A. , Zou W. , Palapattu Ganesh S. 
Published: November 2020

AbstractStrategies that interfere with the binding of the receptor programmed cell death protein-1 (PD-1) to programmed death ligand-1 (PD-L1) have shown marked efficacy against many advanced cancers, including those that are negative for PD-L1. Precisely why patients with PD-L1 negative tumors respond to PD-1/PD-L1 checkpoint inhibition remains unclear. Here, we show that platelet-derived PD-L1 regulates the growth of PD-L1 negative tumors and that interference with platelet binding to PD-L1 negative cancer cells promotes T cell-induced cancer cytotoxicity. These results suggest that the successful outcomes of PD-L1 based therapies in patients with PD-L1 negative tumors may be explained, in part, by the presence of intra-tumoral platelets. Altogether, our findings demonstrate the impact of non-cancer/non-immune cell sources of PD-L1 in the tumor microenvironment in the promotion of cancer cell immune evasion. Our study also provides a compelling rationale for future testing of PD-L1 checkpoint inhibitor therapies in combination with antiplatelet agents, in patients with PD-L1 negative tumors.
Speech-Language Therapy Experiences Across the Life Span of an Individual Who Covertly Stutters: A Thematic Analysis
Authors: Douglass Jill E. , Kennedy Catherine , Smith Kaitlyn 
Published: November 2020

Purpose
The current research study investigates the speech therapy experiences of an individual who covertly stuttered for approximately 40 years; at the time of the interview, she was in her mid-40s.

Method
The single-case study is a qualitative thematic analysis of the speech therapy experiences of one individual across her life span. In addition to her stuttering, the participant lives with a significant primary diagnosis that she has had since birth, which impacts her activities in daily living. Interview questions were open-ended and conducted via Skype. The interview was transcribed, and a thematic analysis of the recorded transcripts was conducted to investigate her experiences in speech therapy as an individual who covertly stutters.

Findings
The current findings reveal five major themes regarding the speech therapy experiences of an individual who covertly stutters: (a) nonindividualized treatment and goals, (b) blaming and shaming associated with speech therapy and stuttering, (c) positive self-regard during speech therapy attendance, (d) the use of avoidance strategies and relation to speech therapy, and (e) the evolution of therapy goals. Direct quotations from the participant are used to support these themes.

Discussion
The significant impact of covert stuttering on an individual is discussed. Results from the participant's experiences indicate an essential need to conduct individualized speech therapy for people who stutter. Speech-language pathologists and others working with persons who stutter maintain a responsibility to recognize the role that case history and counseling play in order to appropriately serve people who covertly stutter.
Re-Imagining Community-Engaged Learning: Service-Learning in Communication Sciences and Disorders Courses During and After COVID-19
Authors: Veyvoda Michelle A. , Van Cleave Thomas J. 
Published: November 2020

Purpose
Community-engaged learning, often practiced through service-learning pedagogy, has been shown to have numerous benefits for both students and communities in communication sciences and disorders undergraduate and graduate programs. While service-learning typically involves students applying their knowledge and learned skills to help satisfy an expressed community need, the recent shift to online learning combined with shuttered community partner organizations may make some practitioners hesitant to pursue the pedagogy. This tutorial reviews the literature on service-learning, its use in online learning, and ways in which faculty in higher education can re-imagine and prioritize community engagement during and after the COVID-19 pandemic.

Conclusions
Continued community-engaged learning, whether through virtual, hybrid, or in-person practice, is still an essential component of a liberal education that can help students practice clinical skills, develop cultural humility and cross-cultural knowledge, gain an understanding of social inequities and health care disparities, and build positive relationships with their community. There are ways for faculty to re-imagine service-learning course delivery in order to maintain the virtues of higher education, sharpen clinical skills, and develop civic engagement among students.
APEX-SEPIA660 Early Science: gas at densities above 107 cm−3 towards OMC-1
Authors: Hacar A. , Hogerheijde M. R. , Harsono D. , Portegies Zwart S. , De Breuck C. , Torstensson K. , Boland W. , Baryshev A. M. , Hesper R. , Barkhof J. , Adema J. , Bekema M. E. , Koops A. , Khudchenko A. , Stark R. 
Published: November 2020

Context. The star-formation rates and stellar densities found in young massive clusters suggest that these stellar systems originate from gas at densities of n(H2) > 106 cm−3. Until today, however, the physical characterization of this ultra high density material remains largely unconstrained in observations.
Aims. We investigate the density properties of the star-forming gas in the OMC-1 region located in the vicinity of the Orion Nebula Cluster (ONC).
Methods. We mapped the molecular emission at 652 GHz in OMC-1 as part of the APEX-SEPIA660 Early Science.
Results. We detect bright and extended N2H+ (J = 7–6) line emission along the entire OMC-1 region. Comparisons with previous ALMA data of the (J = 1–0) transition and radiative transfer models indicate that the line intensities observed in this N2H+ (7–6) line are produced by large mass reservoirs of gas at densities n(H2) > 107 cm−3.
Conclusions. The first detection of this N2H+ (7–6) line at parsec-scales demonstrates the extreme density conditions of the star-forming gas in young massive clusters such as the ONC. Our results highlight the unique combination of sensitivity and mapping capabilities of the new SEPIA660 receiver for the study of the ISM properties at high frequencies.