bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase stability (at 1000°C) of hollow t‐ZrO2 fibers costabilized by lanthana and yttria
Authors: Pang Xu , Xi Chang , Wang Tianchi 
Published: February 2020

AbstractYttrium‐stabilized ZrO2 (YSZ) hollow fibers derived from a ceiba template present a 25%–53% reduction in thermal conductivity compared with traditional YSZ solid fibers. However, after prolonged preservation at 1000°C, tetragonal ZrO2 (t‐ZrO2) can easily transform to monoclinic ZrO2 (m‐ZrO2), which destroys the hollow structure of the YSZ fibers and results in loss of the structural advantages for heat insulation. To overcome this, in this study, biomorphic lanthana and yttrium costabilized zirconia (LaYSZ) fibers with a hollow structure are fabricated by doping appropriate amounts of lanthanum in the raw materials of YSZ fibers. X‐ray diffraction, scanning electron microscopy, and thermal conductivity measurements are utilized to confirm the phase‐stability superiority of LaYSZ fibers to that of YSZ fibers under harsh conditions. After preservation at 1000°C for 150 hours, the m‐ZrO2 content in the LaYSZ hollow fibers increases from 0 to 3.4 mol%, whereas that in the YSZ fibers increases from 0 to 10.25 mol%. Furthermore, owing to their better phase stability at 1000°C, the morphologies and heat‐insulating properties of LaYSZ fibers are more improved in several aspects compared with YSZ fibers.
Fashion sensitive young consumers and fashion garment repair: Emotional connections to garments as a sustainability strategy
Authors: McNeill Lisa S. , Hamlin Robert P. , McQueen Rachel H. , Degenstein Lauren , Garrett Tony C. , Dunn Linda , Wakes Sarah 
Published: February 2020

AbstractWhere clothing consumption has continued to rise around the world, a deeper understanding of how and why garments are disposed of is critical in regard to addressing the issue of textile waste by consumers. The purpose of this study was to explore the garment management processes of young, fashion sensitive consumers, examining their disposal behaviours as well as motivations towards garment end‐of‐life extension through maintenance or repair of damaged fashion clothing. A survey of 161 South Korean young consumers (18–34 years) was conducted, utilizing a fashion sensitivity scale to measure impact on unsustainable garment disposal practices and garment repair behaviour. Further, general recycling behaviour of these individuals was examined, as linked to garment repair propensity. Results indicate that fashion sensitive consumers dispose of garments more rapidly, and with less ethical consideration. However, these same consumers are motivated to repair items that support their fashion identity. The study contributes some useful insight into encouraging garment life extension practise among heavy consumers of fashion, thus extending what is known about fashion garment disposal in the sustainability context.
Relationship between types of food choice motives and well‐being among young and middle‐aged Chinese adults
Authors: Gong Yanping , Li Jian , Xie Julan , Tan Yuxuan 
Published: February 2020

AbstractFood choice plays a vital role in people’s lives and well‐being, and this topic has received more research attention in recent years. The aims of the present research were to identify subgroups of participants who shared similar profiles of multiple motives for food choices, and examine differences across motive types on the well‐being of young and middle‐aged Chinese adults. Participants were 627 Chinese adults aged 18–58 years who completed questionnaire measures. The results of Latent Profile Analysis showed that based on the configurations among different motives for food choice, there were five profiles of food choice motives, corresponding to five types of Chinese adult consumers: unconcerned, mood oriented, weight control oriented, food enthusiast and health oriented. The food enthusiast consumers were more likely to include young adults with high‐income level and educational level, while the unconcerned consumers had a larger share of middle‐aged adults with low income. Results of ANOVA suggested that the types of food choice motives significantly predicted individuals’ well‐being. Specifically, the food enthusiast group had the highest level of well‐being, while the unconcerned group had the lowest level of well‐being. The other three groups had moderate levels of well‐being. The current study is the first to explore the potential influence of food choice motives on well‐being using a person‐centred approach, and the results have practical implications for public health authorities in developing effective interventions, for food companies in tailoring marketing campaigns and for individuals in optimizing food choices.
Why industrial methods do not work in healthcare: an analytical approach
Authors: Cozijnsen Luc , Levi Marcel , Verkerk Maarten J. 
Published: February 2020

AbstractHealthcare professionals and managers in hospitals are frequently suggested to learn from industry and business to improve quality and efficiency. However, evidence that the implementation of industrial techniques and business methods has a meaningful effect on patient outcomes is often lacking. An explanation for this phenomenon is thought to be the complexity of the hospital organisation and the diversity of patients. In this article, we use the practice approach to discuss the application of industrial techniques and business methods in healthcare. We employ a practice model that offers three perspectives to understand professional practices: Identity and intrinsic values, Interests of stakeholders, and Ideals and basic beliefs (Triple I). This model demonstrates that the nature of healthcare practices differs strongly from the nature of industrial and business practices. Healthcare has a moral nature that does not let itself be easily organised along technological or business categories. This may provide a fundamental explanation of why industrial techniques and business methods in general will be less successful in healthcare. At the same time, this model invites hospitals to develop innovative approaches that do justice to the identity and intrinsic values of healthcare. In this process, insights from industry and business cannot be copied but have to be used as sources of inspiration.
Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia
Authors: Szibor Marten , Schreckenberg Rolf , Gizatullina Zemfira , Dufour Eric , Wiesnet Marion , Dhandapani Praveen K. , Debska‐Vielhaber Grazyna , Heidler Juliana , Wittig Ilka , Nyman Tuula A. , Gärtner Ulrich , Hall Andrew R. , Pell Victoria , Viscomi Carlo , Krieg Thomas , Murphy Michael P. , Braun Thomas , Gellerich Frank N. , Schlüter Klaus‐Dieter , Jacobs Howard T. 
Published: February 2020

AbstractCardiac ischaemia‐reperfusion (I/R) injury has been attributed to stress signals arising from an impaired mitochondrial electron transport chain (ETC), which include redox imbalance, metabolic stalling and excessive production of reactive oxygen species (ROS). The alternative oxidase (AOX) is a respiratory enzyme, absent in mammals, that accepts electrons from a reduced quinone pool to reduce oxygen to water, thereby restoring electron flux when impaired and, in the process, blunting ROS production. Hence, AOX represents a natural rescue mechanism from respiratory stress. This study aimed to determine how respiratory restoration through xenotopically expressed AOX affects the re‐perfused post‐ischaemic mouse heart. As expected, AOX supports ETC function and attenuates the ROS load in post‐anoxic heart mitochondria. However, post‐ischaemic cardiac remodelling over 3 and 9 weeks was not improved. AOX blunted transcript levels of factors known to be up‐regulated upon I/R such as the atrial natriuretic peptide (Anp) whilst expression of pro‐fibrotic and pro‐apoptotic transcripts were increased. Ex vivo analysis revealed contractile failure at nine but not 3 weeks after ischaemia whilst label‐free quantitative proteomics identified an increase in proteins promoting adverse extracellular matrix remodelling. Together, this indicates an essential role for ETC‐derived signals during cardiac adaptive remodelling and identified ROS as a possible effector.
Infarct Core Reliability by CT Perfusion is a Time‐Dependent Phenomenon
Authors: R Sivan‐Hoffmann , M Saban , C Buxbaum , F Srour , E Sprecher , A Eran , E Abergel , G Telman 
Published: February 2020

ABSTRACTBACKGROUND AND PURPOSEIn the setting of an extended time window for endovascular treatment (EVT) for acute stroke patients, computed tomography perfusion (CTP) has become a major tool in patient selection. However, there are some data suggesting that the initial ischemic core may be overestimated by CTP depending on stroke onset time. This study aims to evaluate possible predictors of overestimation of infarct core by CTP.METHODSWe studied all consecutive stroke patients undergoing EVT during 1 year who underwent CTP at admission and had a successful recanalization. Admission infarct core was measured on cerebral blood volume maps generated using the Intellispace Portal (Philips Healthcare, Best, the Netherlands) and final infarct was measured on noncontrast follow‐up computed tomography at 24 hours. We defined overestimation of the infarct core as initial core minus final infarct >10 mL.RESULTSOut of 107 patients undergoing EVT in the study period, 60 were anterior circulation and had CTP done at our institute, and of them 31 were compatible with the inclusion criteria (known time of onset, no hemorrhagic conversion, and good recanalization). Median National Institute of Health Stroke Scale on admission was 13. Median time from symptoms to CTP was 148 minutes. Seventeen patients were found to have overestimation of the infarct core. Logistic regression analyses showed time from symptom onset to CTP to be inversely related to overestimation with a cutoff of 170 minutes (sensitivity 94% and specificity 43%).CONCLUSIONOver estimation of the infarct core by CTP in patients undergoing EVT is time dependent and so CTP results among early arrivers should be interpreted cautiously.
Comparison of orthonasal thresholds of key volatile flavor compounds responsible for traditional doenjang flavor in two matrices: Water‐based and soybean‐based model system
Authors: Hong Hyun Hee , Kim Mina K. 
Published: February 2020

AbstractThe aim of this study was to determine the orthonasal thresholds of the key volatile flavor compounds responsible for traditional doenjang flavor in two different matrices: water‐based and soybean‐based model systems. Orthonasal threshold tests were conducted on 10 previously reported key volatile compounds isolated in traditional doenjang. Orthonasal threshold testing was conducted using a 7‐series of 3 ascending forced choice (AFC) methods in two different food matrices (water‐based and soybean‐based). The best estimate threshold (BET) values for each compound in two different matrices were determined. The BET values except for ethyl‐4‐methylpentanoate were higher in the soybean–based model system than in the water‐based model system, suggesting a potential flavor‐food matrix interaction. The results of this study can assist the doenjang industry in strategically designing “traditional doenjang flavor.”Practical applicationsThe findings of this study provided the orthonasal threshold values of 10 volatile compounds representative of traditional doenjang flavors using Korean population and also demonstrated the potential flavor‐food matrix interactions in soybean‐based model system. Finding from this study can provide valuable insights to flavor industry to create just‐about‐right level of traditional doenjang flavor applicable to doenjang paste.
Standardized Xylocarpus moluccensis fruit fraction mitigates collagen-induced arthritis in mice by regulating immune response
Authors: Gupta Priya , Kumar Amit , Pal Subhashis , Kumar Sachin , Lahiri Amit , Kumaravelu Jagavelu , Chattopadhyay Naibedya , Dikshit Madhu , Barthwal Manoj Kumar 
Published: February 2020

Abstract

Objective
This study was undertaken to evaluate the effect of Xylocarpus moluccensis fruit fraction (F018) on the pathogenesis of collagen-induced arthritis in mice.

Methods
Arthritis was induced by intradermal injection of collagen (2 mg/ml) with complete Freund’s adjuvant in DBA/1J mice. F018 was administered orally at 1, 3 and 10 mg/kg for 20 days. Disease progression and mechanism were assessed by micro-CT analysis, RT-PCR, flow cytometry assay, myeloperoxidase (MPO) and MTT assay.

Results
F018 at 3 and 10 mg/kg significantly reduced paw thickness, clinical score, mononuclear cell infiltration and collagen layer depletion in the knee section of collagen-induced arthritis (CIA) mice when compared with collagen-induced arthritis mice alone. Furthermore, F018 treatment in collagen-induced arthritis mice significantly recovered bone volume and trabecular number and decreased the trabecular space by modulating RANKL and OPG mRNA expression in the synovial tissue. F018 treatment in collagen-induced arthritis mice significantly attenuated spleen index, lymphocyte proliferation and paw myeloperoxidase (MPO) activity, pro-inflammatory cytokine TNFα, IL1β, and IL6 mRNA expression and enhanced IL10 mRNA expression in paw tissue. Furthermore, F018 treatment in collagen-induced arthritis mice significantly reduced splenic dendritic cell maturation and Th17 cells. In culture, F018 significantly decreased collagen-induced arthritis-FLS proliferation and promoted apoptosis.

Conclusion
F018 may serve as a potential curative agent for arthritis.
Prevalence of asthma at a school‐based health clinic in Nicaragua
Authors: Banasiak Nancy Cantey , Meadows‐Oliver Mikki 
Published: February 2020

AbstractBackgroundWorldwide, it is estimated that 235‐334 million people have been diagnosed with asthma. In Nicaragua, the current asthma rate for children 13–14 years of age was 15.2%.PurposeThe purpose of this study was to determine the prevalence of asthma at this school‐based health clinic in Managua, Nicaragua, associated symptoms or diseases, determine asthma classification, medications, and hospitalization rates.MethodsA retrospective chart review was performed on all pediatric patient's medical records seen in the clinic during a 5‐day period (n = 105).ResultsA total of 23 patients (21.9%) had asthma documented in the medical chart and were included in the analysis. Of the 23 patients, 3 (13%) patients were classified with intermittent asthma while the rest of the patients (87%) were not classified. Albuterol was prescribed for 19 (86%) of the patients with two patients who had both albuterol and QVAR® prescribed. Six (26%) patients had a family history of asthma.DiscussionThis study demonstrated the prevalence of asthma in school‐aged children in Nicaragua is significant and higher than previously reported. The lack of a classification of asthma prevents patients from potentially being treated appropriately.
Real‐world experience of elbasvir/grazoprevir in Taiwan: This study was focused on liver and renal adverse effects
Authors: Hsieh Yi‐Chung , Lin Chih‐Lang , Hung Chao‐Hung , Chen Chien‐Hung , Tung Shui‐Yi , Lin Chun‐Yen , Hu Tsung‐Hui , Lu Sheng‐Nan , Chien Rong‐Nan , Sheen I‐Shyan 
Published: February 2020

AbstractElbasvir/grazoprevir with or without ribavirin has excellent efficacy and safety for the treatment of hepatitis C virus (HCV) genotype 1 and 4 patients. The real‐world experience has been reported but the detailed analysis of liver and renal adverse effects is lacking. This study evaluated the real‐world experience relating to the effectiveness and liver/renal safety of elbasvir/grazoprevir in HCV genotype 1 patients with compensated liver disease. In the four medical centres of Chang Gung Medical System, 350 HCV genotype 1 patients with compensated liver disease who were treated with elbasvir/grazoprevir were enrolled. Clinical characteristics and laboratory data were collected. The effectiveness (sustained virologic response 12 weeks after end of treatment, SVR12) and safety were assessed. A consecutive series of 350 patients with a mean age of 68.8 ± 10.0 years old were enrolled. The majority were treatment‐naïve (72.3%), genotype 1b (97.7%) and advanced fibrosis/cirrhosis (94.3%). Seventy‐nine (22.6%) had hepatocellular carcinoma and 23 (6.6%) had coinfection with hepatitis B. The effectiveness of SVR12 was 94.6% (95% CI: 92.2%‐97.0%) in the full analysis set and 99.1% (95% CI: 98.1%‐100.1%) in the per‐protocol set. There were two relapses and one nonresponder. Seven (2.0%) patients had adverse events resulting in premature discontinuation of treatment. Five of them were considered drug‐related. One was due to autoimmune hepatitis. Contrary to previous reports, around 49% of ALT elevation was observed after 8 weeks, and in two patients was due to hepatitis B flares. As to the renal function during the course of therapy, a minor deterioration of eGFR was observed in patients with baseline eGFR ≥60 mL/min/1.73 m2, but not in those with baseline eGFR <60, <60‐30 or <30 mL/min/1.73 m2. In this real‐world data, elbasvir/grazoprevir was effective with few liver/renal adverse effects. One patient developed autoimmune hepatitis.
Association of fecal sample collection technique and treatment history withTritrichomonas foetuspolymerase chain reaction test results in 1717 cats
Authors: Hedgespeth Barry A. , Stauffer Stephen H. , Robertson James B. , Gookin Jody L. 
Published: February 2020

AbstractBackgroundFecal polymerase chain reaction (PCR) testing forTritrichomonas foetusis considered the most sensitive means for diagnosis of infection but results could be influenced by fecal collection technique and prior use of antimicrobial drugs.ObjectivesTo establish any association between fecal collection technique or treatment history and results of fecal PCR testing forT. foetus.AnimalsFecal samples from 1717 cats submitted by veterinarians between January 2012 and December 2017.MethodsThis study used a retrospective analysis.T. foetusPCR test results from 1808 fecal samples submitted for diagnostic testing were examined for their association with method of fecal collection and prior antimicrobial treatments. Data were collected from sample submission form.ResultsPositiveT. foetusPCR test results were obtained for 274 (16%) cats.Fecal samples collected via fecal loop had increased probability of positive PCR test results (odds ratio [OR] 2.04, 95% confidence interval [CI] 1.31‐3.17,P= .002) compared to samples collected by colonic flush. There was no association between PCR test results and treatment history, treatment type, or prior treatment with ronidazole. After an initial positive PCR test, 4/19 (21%; 95% CI 2.7%‐39.4%) cats treated with ronidazole had a second positive test result.Conclusions and Clinical ImportanceResults of this study support that fecal samples collected by loop might be better for PCR diagnosis ofT. foetusinfection. Lack of association of ronidazole with PCR test results and a 21% all‐potential‐causes failure rate of ronidazole in cats with preconfirmed infection are important limitations to use of this drug.
Dietary patterns and diet quality during pregnancy and low birthweight: The PRINCESA cohort
Authors: Ancira‐Moreno Monica , O'Neill Marie S. , Rivera‐Dommarco Juan Ángel , Batis Carolina , Rodríguez Ramírez Sonia , Sánchez Brisa N. , Castillo‐Castrejón Marisol , Vadillo‐Ortega Felipe 
Published: February 2020

AbstractAlthough the isolated effects of several specific nutrients have been examined, little is known about the relationship between overall maternal diet during pregnancy and fetal development and growth. This study evaluates the association between maternal diet and low birthweight (LBW) in 660 pregnant women from the Pregnancy Research on Inflammation, Nutrition,& City Environment: Systematic Analyses (PRINCESA) cohort in Mexico City. Using prior day dietary intake reported at multiple prenatal visits, diet was assessed prospectively using a priori (Maternal Diet Quality Score [MDQS]) and a posteriori (dietary patterns extracted by factor analysis) approaches. The association between maternal diet and LBW was investigated by logistic regression, controlling for confounders. Adherence to recommended guidelines (higher MDQS) was associated with a reduced risk of LBW (OR, 0.22; 95% confidence interval [0.06, 0.75], P < .05, N = 49) compared with the lowest adherence category (reference group), controlling for maternal age, education, height, marital status, pre‐pregnancy body mass index, parity, energy intake, gestational weight gain, and preterm versus term birth; a posteriori dietary patterns were not associated with LBW risk. Higher adherence to MDQS was associated with a lower risk of having an LBW baby in this sample. Our results support the role of advocating a healthy overall diet, versus individual foods or nutrients, in preventing LBW.
The efficacy of electronic health interventions targeting improved sleep for achieving prevention of weight gain in adolescents and young to middle‐aged adults: A systematic review
Authors: Allman‐Farinelli Margaret , Chen Juliana , Chevance Guillaume , Partridge Stephanie R. , Gemming Luke , Patrick Kevin , Godino Job G. 
Published: February 2020

SummarySleep is emerging as a modifiable risk factor in counteracting harmful weight gain. Electronic and mobile devices offer a channel for wide‐reaching intervention delivery. This systematic review aimed to determine the efficacy of interventions that included sleep behaviour as part of health promotion for preventing weight gain. Seven databases were searched from 1 January 2000 until 28 June 2019. Eligible studies were controlled trials of weight gain prevention programs that addressed sleep in healthy participants aged 13 to 44 years of age. The primary outcome was change in measured or self‐reported weight. From 824 publications located, only six eligible trials with a total of 3,277 participants were identified and all addressed multiple behaviours. One study demonstrated a decrease in weight for the intervention group, and two other studies showed a decreased prevalence of overweight and obesity. Only one trial showed improved sleep duration but failed to show differences in weight. No definitive conclusions concerning the efficacy of electronic weight gain prevention interventions that include sleep can be made, but future trials should provide more detail about intervention techniques used, employ objective sleep and physical activity measures and undertake mediation analysis to judge the contributions of changes in sleep to study outcomes. PROSPERO REGISTRATION: CRD42019121879.