bluuebunny/crossref_metadata_2025_split huggingface dataset:
How should we define clinically significant improvement on Patient-Reported Outcomes Measurement Information System (PROMIS) for patients undergoing Knee Meniscal Surgery?
Authors: Lu Yining , Nwachukwu Benedict , Beletsky Alexander , Patel Bhavik , Yanke Adam , Verma Nikhil , Cole Brian , Bush-Joseph Charles , Bach Bernard , Forsythe Kelechi Okoroha Brian 
Published: July 2020

Objectives: The Patient-Reported Outcomes Measurement Information System (PROMIS) attempts to optimize patient reported outcome (PRO) instruments by utilizing item response theory (IRT) and computer adaptive testing (CAT). Relatively little is known about clinically significant outcome (CSO) improvements on the PROMIS Physical Function (PF) CAT. The objective of this study is to define the minimal clinically important difference (MCID), substantial clinical benefit (SCB) and patient-acceptable symptom state (PASS) of the PROMIS PF CAT in arthroscopic meniscal surgery. Methods: The PROMIS PF CAT, Short Form-12 Health Survey (SF-12 physical health [PCS] and mental health [MCS]), Veterans Rand-12 Health Survey (VR-12 physical health [PH] and mental health [MH]), and the Marx Activities Ratings Scale were administered pre- and post- operatively to patients undergoing arthroscopic meniscal surgery. Six months postoperatively, patients graded their knee function based on a domain-specific anchor question. Answers to the anchor questions were dichotomized to indicate achievement of SCB and MCID. A satisfaction anchor question was used to indicate achievement of PASS. Receiver operating characteristic (ROC) analysis determined the relevant psychometric values. Cutoff analysis was performed to find preoperative PRO scores predicting CSO achievement. Results: Sixty patients (N = 27, 45% female) were included, with mean age of 45.0 ± 14.0 years and average follow up of 24.0 + 1.2 weeks. The most common indication for knee arthroscopy was partial meniscectomy (N = 53; 88.3%) followed by meniscal repair (N = 7; 11.7%). MCID on PROMIS PF was calculated to be 2.08 (AUC: 0.75, 95% CI: 0.57 - 0.94). Net score improvement equivalent to achievement of SCB was found to be 7.41 (AUC: 0.77, 95% CI: 0.55 – 0.99). PASS was found to be 45.47 (AUC: 0.89, 95% CI: 0.79-0.99). Preoperative score below 37.6 on the PROMIS PF CAT predicted achievement of MCID (AUC: 0.76, 95% CI: 0.64-0.88), while scores above 41.7 predicted achievement of PASS (AUC: 0.76, 95% CI: 0.63-0.89). Absence of pre-existing arthritis and higher baseline functional status were also found to be statistically significant predictors of achieving CSOs. Conclusion: Our study defined MCID, SCB, and PASS, for the PROMIS PF CAT. We found that a pre-operative score below 37.6 was predictive for achieving a meaningful clinical change with surgery, while a pre-operative score above 41.7 was predictive of achievement of an acceptable post-operative health state. [Table: see text][Table: see text][Table: see text][Figure: see text]
Establishing the Minimal Clinically Important Difference, Substantial Clinical Benefit, and Patient Acceptable Symptomatic State following Primary Medial Patellofemoral Ligament Reconstruction
Authors: Huddleston Hailey , Naveen Neal , Southworth Taylor , Nwachukwu Benedict , Cole Brian , Yanke Adam , Walsh Justin 
Published: July 2020

Objectives: Medial patellofemoral ligament (MPFL) reconstruction is an effective surgical procedure for patients with recurrent lateral dislocations. Outcome measurements can identify the success of a surgical procedure but are shifting away from absolute values or deltas of patient-reported outcomes (PROs) towards the minimal clinically important difference (MCID), substantial clinical benefit (SCB), and patient acceptable symptomatic state (PASS), representing the smallest clinical improvement that patients perceive as important, the threshold at which patients notice a considerable improvement, and patient satisfaction with their outcome, respectively. To our knowledge no prior study has defined these thresholds in MPFL reconstruction patients. Methods: An institutional database was reviewed for patients who underwent primary MPFL reconstruction between August 2015 to February 2018 with a minimum 6-month follow-up. IKDC, Kujala and KOOS were administered to all patients pre-operatively and at 6-months and 1-year post-operatively. An anchor-based approach with a receiver-operator curve/area under the curve analysis using the Youden index was performed to calculate the MCID, SCB and PASS. The predictive power was determined to be acceptable with AUC≥70% and excellent with AUC≥80%. Results: From 2015 to 2018, 93 of 162 patients (mean age 23.7±10.1 years; 25 males, 68 females) completed for 6-month follow-up. At 6-months follow-up, SCB and PASS were defined with acceptable predictive power for all scores listed, while MCID achieved this for KOOS pain and sports subscores only (Table 1). At 1-year follow-up, SCB and PASS were each defined with acceptable predictive power for all scores listed, while MCID achieved this mark for KOOS pain and quality of life subscores as well as both Kujala scales. Conclusion: This study establishes MCID, SCB and PASS for IKDC, Kujala, and KOOS subscores at 6-months and 1-year postoperatively with excellent predictive power for 19/23 PROMs investigated at 1-year. These findings represent important benchmarks in patients undergoing primary MPFL reconstruction.
Risk Factors for Arthrofibrosis in Tibial Spine Fractures: A National 10-Site Multicenter Study
Authors: Aoyama Julien , Mistovich Justin , Yen Yi-Meng , Ellis Henry , Lee Jay , Fabricant Peter , Green Daniel , Cruz Aristides , McKay Scott , Schmale Gregory , Ganley Theodore , Bram Joshua 
Published: July 2020

Objectives: To identify risk factors for developing arthrofibrosis after TSF treatment. Methods: This was a retrospective, multi-center study across ten institutions of 448 patients <25 years old who presented to care with a tibial spine fracture between 1/2000 and 2/2019. Patient records were reviewed for a multitude of pre-operative, intra-operative, and post-operative characteristics. Patients were then separated into two cohorts based on if they suffered from post-treatment arthrofibrosis. Results: Chart review demonstrated that 43 (9.6%) of the patients suffered from post-treatment arthrofibrosis. There were no demographic differences observed between the two groups. However, based on MRIs at the time of injury, distal femoral and proximal tibial growth plates were more frequently closed in the arthrofibrosis group (17.6% vs 4.4%, p=0.023 for both comparisons). Additionally, there was no difference in Meyers & McKeever (MM) classification (p=0.597). All arthrofibrosis patients received operative treatment (p=0.003), though there was no difference in fixation technique (p=0.734). Intraoperatively, a higher number of screws were used in the arthrofibrosis group (p=0.002) with the placement of hardware more likely to be epiphyseal (p=0.007). Other operative parameters including number of sutures were not different. Post-operatively, arthrofibrosis patients were more likely to have been immobilized in a cast (p<0.001) with no difference observed for weight-bearing status. After multivariate regression, screw number (OR 8.9, CI 1.9-41.7, p=0.005) and immobilization in a cast (OR 7.8, CI 1.0-60.4, p=0.049) remained significant predictors of post-treatment arthrofibrosis. Conclusion: This serves as the largest study of tibial spine fractures to analyze risk factors for the development of post-treatment arthrofibrosis. Our study demonstrates that pre-operative factors were largely similar between groups, but that intra-operative decisions, including the number of screws used for fixation and placement of hardware in relation to the physis, were significant predictors of post-treatment arthrofibrosis. These findings may influence operative decision-making in tibial spine fracture patients. Additionally, post-operative immobilization in a cast should be avoided given the high risk of arthrofibrosis. [Table: see text]
Knees with Smaller Posterior Tibial Slope And More Concave Medial Tibial Plateau Are At Higher Risk Of Isolated Meniscal Injuries
Authors: Murray Martha , Kiapour Ata , Barnett Samuel 
Published: July 2020

Objectives: Meniscal injuries are extremely common. Several anatomical features of the knee, including the tibial plateau morphology, have been shown to influence knee biomechanics and the risk of ligamentous injuries. Little is known, however, how these morphological features influence the risk of isolated meniscal injuries in the ACL intact knee. In the current study, we used MRI and 3D image analysis to investigate anatomical variables of knees in patients with and without isolated meniscus tears. We hypothesized that there are differences in slopes and concavity of the tibial plateau between patients with isolated meniscus tears and matched normal controls. Methods: 65 subjects with first-instance isolated medial or lateral meniscal injuries requiring surgical fixation (Age: 15 +/- 2 years, BMI: 23.2 +/- 3.7 Kg/m2; 43% females) were matched to 65 subjects with normal knees and no prior injuries (Age: 15 +/- 2 years, BMI: 23.1 +/- 3.8 Kg/m2; 43% females) based on age, BMI and sex. Sagittal Proton Density SPACE MR images (preoperative for injured group) were used to measure the posterior slope of the medial (MTS) and lateral (LTS) tibial plateau, coronal slope of the tibial plateau (CTS), and the maximum depth of the medial tibia plateau (MTD, as a measure of medial tibial plateau concavity), following established techniques-Figure 1. Two-sample t-test was used to compare the quantified anatomical features between the cases and matched controls. Results: There were no differences in age (p = 0.999), sex distribution (p = 0.999) and BMI (p = 0.963) between the two cohorts. Compared to matched controls, patients with isolated meniscal tears had lower LTS (3.6 +/- 3.2 vs 5.6 +/- 3.0 degrees; p < 0.001), lower MTS (3.4 +/- 2.9 vs 4.9 +/- 2.5 degrees; p = 0.001) and deeper MTD (2.4 +/- 0.8 vs 1.5 +/- 0.8 mm; p < 0.001). There was no difference in CTS between the groups (3.6 +/- 1.6 vs 3.9 +/- 2.2 degrees; p = 0.300). Conclusion: This study suggests that subjects with isolated meniscus tear have a lower posterior tibial slope and a deeper MTD (more concave medial tibial plateau) than matched population who do not have a meniscus tear. This is contrary to what is known for ACL tears, where a higher posterior tibial slope and a shallower MTD have been associated with an increased risk of ACL tear. During load-bearing activities, in particular high impact movements such as jumping, increased tibial slope and decreased MTD have shown to result in greater anterior shear forces across the knee. In contrast, the less sloped and more concave plateau will experience lower shear forces but more compression, which could be detrimental to the meniscus. This study provides preliminary evidence suggesting a link between tibial plateau morphology and risk of isolated meniscal injuries. Further mechanistic studies are required to better understand the interaction between knee morphology, meniscal loading and subsequent risk of injury. [Figure: see text]
Femoral Tunnel Fixation for Medial Patellofemoral Ligament Reconstruction in the Growing Patient is Safe for Future Growth
Authors: Brenner Madison , Wyatt Charles , Zynda Aaron , Wilson Philip , Ellis Henry , Gross Bruno 
Published: July 2020

Objectives: Medial patellofemoral ligament (MPFL) reconstruction has been shown to be a successful treatment for patients with recurrent patellar instability and is increasingly used to treat skeletally immature patients. The purpose of this study is to compare radiographic parameters prior to and following an MPFL reconstruction with femoral tunnel fixation in the skeletally immature patient to investigate potential effects on the physis and future growth. Methods: Skeletally immature patients undergoing isolated MPFL reconstruction were retrospectively reviewed. Fixation of proximal MPFL was performed as a femoral socket using Schottle’s point with the entry approximately 5 mm distal to the physis. Patients with open growth plates and 1-year postoperative standing alignments were included. Radiographic measures of patellar tilt, patellar height, patellar subluxation, and trochlear dysplasia were compared pre-operatively and post-operatively on the operative limb. Pre- and post-operative coronal alignment and limb length measurements were compared between the operative and non-operative limbs. Results: Nineteen skeletally immature patients with an average age of 11.6 years (range 5-15 years old) underwent isolated MPFL reconstruction. The average follow-up time was 24 months. No significant differences were found between the change in femur (0.49 mm, p=0.526) or total limb length (1.08 mm, p=0.241) when comparing the operative to the non-operative limb, with an average of 47 mm of growth in the operative limb seen during the time period. There was no significant difference in the change in LDFA between operative and non-operative limb as well as symmetric changes noted in the mechanical axis. The change in patellar tilt on the operative limb was found to be significant (12.78°, p=0.030), and the change in patellar height by Caton-Deschamps approached significance (0.08mm, p= 0.077). No significant difference was found with trochlear dysplasia measures. Conclusion: The present study suggests MPFL reconstruction with femoral tunnel fixation is safe and does not result in growth disturbance in skeletally immature patients. [Table: see text]
Increased Tibiofemoral Rotation with Increasing Severity of Patellar Instability in the Pediatric Population
Authors: James Evan , Aitchison Alexandra , Schlichte Lindsay , Wang Grace , Green Daniel , Lin Kenneth 
Published: July 2020

Objectives: Tibiofemoral rotation (TFR), specifically external tibial rotation, has been recently identified as a potential contributing factor to patellar instability. However, no previous studies have explored the clinical effects of differing degrees of TFR in relation to patellar instability. The purpose of this study is to investigate the relationship between severity of instability with degree of TFR. Our hypothesis is that fixed or obligatory dislocators (FOD) are more likely to have increased external TFR (tibial external rotation compared to femur) than standard patellar instability (SPI) patients requiring medial patellofemoral ligament (MPFL) reconstruction, who will have similar or slightly increased external TFR compared to normal controls. Methods: A retrospective study was performed with patients from 3 cohorts from April 2009 to February 2019: FOD, SPI, and controls with normal magnetic resonance imaging (MRI) of the knee. All FOD patients from the study time frame were analyzed, while controls and SPI patients were randomly selected. Patients were included for age under 18 years and diagnosis corresponding to one of the three cohorts, and excluded for outside institution MRI, and previous MPFL reconstruction or tibial tubercle osteotomy. TFR was measured on preoperative axial MRI using the posterior femoral and tibial condylar lines (Figure 1). Tibial tubercle to trochlear groove distance (TT-TG) was measured. Intraclass correlation coefficient (ICC) was calculated among 3 measurers. Statistical analysis using ANOVA and t-test was performed with significance set at α=0.05. Results: A total of 57 patients were included, 19 in each cohort. Average age was 13.2 years (range 10-17 years), with 31 females (54%). ICC for TT-TG and TFR were 0.90 and 0.72, respectively. TT-TG differed between the controls and SPI patients (both P<0.001), and controls and FOD patients (P<0.001), but not between SPI and FOD patients (P=0.12). TFR differed among the three groups: 8.4° (SD 16.7°) external TFR in FOD, 1.6° (SD 5.4°) external TFR in SPI, and 2.5° (SD 5.8°) internal TFR in controls (P=0.0089). FOD patients had significantly greater external tibial rotation than the SPI group (P=0.047). Conclusions: The degree of TFR is correlated with severity of patellar instability, with greater external tibial rotation seen in FOD than SPI patients, while TT-TG was not different. Further information on the relationship of TFR and patellar instability will not only improve understanding of pathogenesis and prognosis, but may also direct surgical treatment strategies in refractory or severe cases.
Defining MCID in patients following meniscectomy and the role of pre-operative PROMIS scores in predicting clinical improvement
Authors: Franovic Sreten , Kuhlmann Noah , Korn Michael , Pietroski Alex , Schlosser Collin , Makhni Eric , Moutzouros Vasilios 
Published: July 2020

Objectives: The Patient-Reported Outcomes Measurement Information System (PROMIS) is emerging as a valid and efficient means of collecting patient outcomes in patients with meniscal tears. Our purpose was to examine the role of pre-operative PROMIS computer adaptive test (CAT) scores in predicting post-operative PROMIS CAT scores, as well as the minimal clinically important difference (MCID) following meniscectomy. We hypothesize that pre-operative PROMIS CAT scores will directly impact both post-operative PROMIS CAT scores and likelihood of achieving MCID. Methods: Patients undergoing arthroscopic meniscectomy that completed PROMIS CAT forms for physical function (PROMIS-PF), pain interference (PROMIS-PI), and depression (PROMIS-D) were utilized. MCID was calculated according to the distribution methodology, and receiver operating characteristics (ROC) were utilized to determine if pre-operative scores were predictive of post-operative outcomes. Preoperative cutoffs were used to predict which patients would likely meet MCID, using 90% specificity. Results: A total of 135 patients met our inclusion criteria. PROMIS-PF, PROMIS-PI, and PROMIS-D improved 3 months after surgery (p<0.01). 62% of the entire cohort met MCID for PROMIS-PF, while 68% met MCID for PROMIS-PI, and 41% met MCID for PROMIS-D. Individuals with PROMIS-PF scores below 34.9 yielded an 82% probability of achieving MCID, while PROMIS-PI scores above 67.5 yielded an 86% probability of achieving MCID and a cutoff of 58.9 for PROMIS-D yielded a 60% probability of achieving MCID, with 90% specificity. Conclusions: Significant portions of patients undergoing meniscectomy achieve MCID in PROMIS-PF, PROMIS-PI, and PROMIS-D, at the 3-month time point. In particular, patients with PROMIS-PF scores of <34.9 are far more likely to achieve MCID for physical function.
The serial changes of static anterior tibial subluxation on MRI after double-bundle anterior cruciate ligament reconstruction
Authors: Fukuda Hideaki , Ogura Takahiro , Takahashi Kenji , Asai Shigehiro 
Published: July 2020

Objectives: Static anterior tibial subluxation after an anterior cruciate ligament (ACL) injury highlights the abnormal relationship between the tibia and femur in patients with ACL insufficiency. One of the aims of ACL reconstruction is to restore the normal tibiofemoral relationship. However, several studies indicated that an abnormal tibiofemoral relationship remained after single-bundle (SB) ACL reconstruction. The purpose of this study was to determine the serial changes of static relationship between tibia and femur in patient who had double-bundle ACL reconstruction with acute and chronic injuries. Methods: Thirty five patients who underwent double-bundle ACL reconstruction between January 1 to July 31, 2017 were included in this prospective study and divided two groups: the acute ACL injury group and the chronic ACL injury group (more than 6 month after injury). All participants underwent preoperative and postoperative magnetic resonance imaging (MRI) at 3 weeks, 3, 6 and 12 months. Anterior tibial subluxation (ATS) of the medial and lateral compartments relative to the femoral condyles were measured on MRI. Results: There were no significant differences in the age and KT side to side difference between both groups (Table 1). The ATS measurements are shown in table 2. In lateral compartment, the ATS in the acute ACL injury group was 5.3mm before surgery, while it was -0.31mm, 3.4mm, 3.5mm and 4.9mm at 3 weeks, 3, 6, 12months after surgery, respectively. The ATS in the chronic ACL injury group was 6.7mm before surgery, while it was 0.47mm, 3.9mm, 4.6mm and 5.9mm at 3 weeks, 3, 6, 12months after surgery, respectively. No significant difference was found between 2 groups. In medial compartment, the ATS in the acute ACL injury group was 1.8mm before surgery, while it was -1.6mm, 0.28mm, 0.93mm and 2.1mm at 3 weeks, 3, 6, 12months after surgery, respectively. The ATS in the chronic ACL injury group was 2.5mm before surgery, while it was -1.4mm, 1.6mm, 1.7mm and 3.0mm at 3 weeks, 3, 6, 12months after surgery, respectively. No significant difference was found between 2 groups. Conclusion: In both of lateral and medial compartment, the ATS was not significant different between acute and chronic ACL injuries before surgery. In lateral compartment, at 3 weeks, 3months and 6months after surgery, ATS was significantly less than before surgery in both groups. At 12 months, ATS was not significant different from before surgery in both groups. In medial compartment, at 3 weeks, ATS were significantly less than before surgery in both groups. After 3 months, ATS was not significant different from before surgery in both groups. The ATS was not significant different between acute and chronic ACL injuries in the same period after surgery. [Figure: see text][Figure: see text][Figure: see text][Figure: see text]