bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac Troponin Composition Characterization after Non ST-Elevation Myocardial Infarction: Relation with Culprit Artery, Ischemic Time Window, and Severity of Injury
Authors: Damen Sander A J , Cramer Gilbert E , Dieker Hendrik-Jan , Gehlmann Helmut , Ophuis Ton J M Oude , Aengevaeren Wim R M , Fokkert Marion , Verheugt Freek W A , Suryapranata Harry , Wu Alan H , van Wijk Xander M R , Brouwer Marc A 
Published: September 2020

Abstract

Background
Troponin composition characterization has been implicated as a next step to differentiate among non-ST elevation myocardial infarction (NSTEMI) patients and improve distinction from other conditions with troponin release. We therefore studied coronary and peripheral troponin compositions in relation to clinical variables of NSTEMI patients.

Methods
Samples were obtained from the great cardiac vein (GCV), coronary sinus (CS), and peripheral circulation of 45 patients with NSTEMI. We measured total cTnI concentrations, and assessed both complex cTnI (binary cTnIC + all ternary cTnTIC forms), and large-size cTnTIC (full-size and partially truncated cTnTIC). Troponin compositions were studied in relation to culprit vessel localization (left anterior descending artery [LAD] or non-LAD), ischemic time window, and peak CK-MB value.

Results
Sampling occurred at a median of 25 hours after symptom onset. Of total peripheral cTnI, a median of 87[78-100]% consisted of complex cTnI; and 9[6-15]% was large-size cTnTIC. All concentrations (total, complex cTnI, and large-size cTnTIC) were significantly higher in the CS than in peripheral samples (P &lt; 0.001). For LAD culprit patients, GCV concentrations were all significantly higher; in non-LAD culprit patients, CS concentrations were higher. Proportionally, more large-size cTnTIC was present in the earliest sampled patients and in those with the highest CK-MB peaks.

Conclusions
In coronary veins draining the infarct area, concentrations of both full-size and degraded troponin were higher than in the peripheral circulation. This finding, and the observed associations of troponin composition with the ischemic time window and the extent of sustained injury may contribute to future characterization of different disease states among NSTEMI patients.
Characterizing several properties of high-dimensional random Apollonian networks
Authors: Zhang Panpan 
Published: September 2020

Abstract
In this article, we investigate several properties of high-dimensional random Apollonian networks, including two types of degree profiles, the small-world effect (clustering property), sparsity and three distance-based metrics. The characterizations of the degree profiles are based on several rigorous mathematical and probabilistic methods, such as a two-dimensional mathematical induction, analytic combinatorics and Pólya urns, etc. The small-world property is uncovered by a well-developed measure—local clustering coefficient and the sparsity is assessed by a proposed Gini index. Finally, we look into three distance-based properties; they are total depth, diameter and Wiener index.
Pleural invasion, epidermal growth factor receptor mutation and carcinoembryonic antigen level affect pleural lavage cytology-positive status in non-small-cell lung cancer
Authors: Fujibayashi Yusuke , Ogawa Hiroyuki , Kitazume Mai , Nishikubo Megumi , Nishioka Yuki , Kimura Kenji , Tane Shinya , Kitamura Yoshitaka , Nishio Wataru 
Published: September 2020

Abstract

OBJECTIVES
Pleural invasion (pl) is strongly associated with the pleural lavage cytology (PLC) status. We analysed tumours with pl and evaluated the relationship between the PLC status and pl.

METHODS
We retrospectively reviewed 428 surgically treated patients who had been diagnosed with non-small-cell lung cancer with pl and had their PLC status examined between 2000 and 2016. We investigated the influence of a PLC-positive status on the prognosis and searched for the factors predictive of a PLC-positive status.

RESULTS
Seventy-eight (18%) patients were PLC positive. The recurrence-free survival of PLC-positive patients was significantly worse than that of PLC-negative patients in pl1 and pl2, but not in pl3 (5-year recurrence-free survival rate, PLC positive versus PLC negative: pl1, 22.0% vs 60.0%, P = 0.002; pl2, 30.4% vs 59.7%, P = 0.015; pl3, 50.0% vs 59.6%, P = 0.427). A multivariable analysis showed that the degree of pl (pl2–3 versus pl1) [odds ratio (OR) 5.34, P &lt; 0.001] was an independent predictive factor for PLC positivity. Epidermal growth factor receptor (EGFR) mutation positivity (OR 5.48, P = 0.042) and carcinoembryonic antigen (CEA) ≥5 ng/ml (OR 3.78, P = 0.042) were associated with a PLC-positive status in patients with pl2–3. We found that the PLC-positive rate in patients with pl2–3 was 35.6%; however, if the tumour was EGFR mutation positive and had CEA ≥5 ng/ml, the PLC-positive rate increased to 77%.

CONCLUSIONS
If a tumour was suspected of being pl2–3 and had EGFR mutation positivity and CEA ≥5 ng/ml, the PLC-positive rate was extremely high.

Clinical trial registration number
Hyogo Cancer Center, G-138.
Lifestyle, metabolism and environmental adaptation inLactococcus lactis
Authors: Kleerebezem Michiel , Bachmann Herwig , van Pelt-KleinJan Eunice , Douwenga Sieze , Smid Eddy J , Teusink Bas , van Mastrigt Oscar 
Published: September 2020

ABSTRACTLactococcus lactis serves as a paradigm organism for the lactic acid bacteria (LAB). Extensive research into the molecular biology, metabolism and physiology of several model strains of this species has been fundamental for our understanding of the LAB. Genomic studies have provided new insights into the species L. lactis, including the resolution of the genetic basis of its subspecies division, as well as the control mechanisms involved in the fine-tuning of growth rate and energy metabolism. In addition, it has enabled novel approaches to study lactococcal lifestyle adaptations to the dairy application environment, including its adjustment to near-zero growth rates that are particularly relevant in the context of cheese ripening. This review highlights various insights in these areas and exemplifies the strength of combining experimental evolution with functional genomics and bacterial physiology research to expand our fundamental understanding of the L. lactis lifestyle under different environmental conditions.
Quasi-reliable estimates of effective sample size
Authors: Fang Youhan , Cao Yudong , Skeel Robert D 
Published: September 2020

Abstract
The efficiency of a Markov chain Monte Carlo algorithm for estimating the mean of a function of interest might be measured by the cost of generating one independent sample, or equivalently, the total cost divided by the effective sample size, defined in terms of the integrated autocorrelation time. To ensure the reliability of such an estimate, it is suggested that there be an adequate sampling of state space— to the extent that this can be determined from the available samples. A sufficient condition for adequate sampling is derived in terms of the supremum of all possible integrated autocorrelation times, which leads to a more stringent condition for adequate sampling than that simply obtained from integrated autocorrelation times for functions of interest. A method for estimating the supremum of all integrated autocorrelation times, based on approximation in a finite-dimensional subspace, is derived and evaluated empirically.
Stokes Matrices for Confluent Hypergeometric Equations
Authors: Hien Marco 
Published: September 2020

Abstract
We apply the method of [7] to compute the Stokes matrices of non-resonant confluent hypergeometric differential equations. We discuss the ambiguity of the presentation of the Stokes matrices regarding different choices. The results rely on an explicit description of the perverse sheaf associated to the non-confluent regular singular hypergeometric system arising via Fourier–Laplace transform. We give assumptions on the parameter such that the Stokes matrices have rational or real values. Under some more restrictive conditions, the Stokes matrices had been computed by Duval–Mitschi before. We compare our results with their formulae in the unramified case.
Accelerated Extraction and Analysis of Ethyl Glucuronide in Hair by Means of Pressurized Liquid Extraction Followed by Liquid Chromatography–Tandem Mass Spectrometry Determination
Authors: Vincenti Flaminia , Montesano Camilla , Oliva Eleonora , Fanti Federico , Vincenti Marco , Salomone Alberto , Compagnone Dario , Curini Roberta , Sergi Manuel 
Published: September 2020

Abstract
The measurement of ethyl glucuronide (EtG) in hair is an established practice to evaluate alcohol consumption habits of the donors; nevertheless, analytical variability has shown to be an important factor to be considered: measured EtG values can vary significantly as a consequence of analyte washout during decontamination, pulverization of samples, extraction solvent and incubation temperature. In the present study, we described a new method for automated hair decontamination and EtG extraction from the inner core of the hair by using pressurized liquid extraction (PLE), followed by solid-phase extraction (SPE) cleanup; validation was performed according to SWGTOX guidelines. The extraction efficiency of the new method was evaluated by comparing the results with those obtained by a validated and ISO/IEC 17025:2005 accredited method; an average positive difference of + 32% was observed when the extraction was performed by PLE. The effect of hair pulverization was also studied, and a good correlation between cut and milled hair was observed, implying that PLE allowed a highly efficient extraction of EtG from the inner keratin core of the hair, no matter if it has been cut or pulverized. Finally, to verify the results, paired aliquots of 27 real hair samples were analyzed with both PLE and a protocol optimized by design-of-experiment strategies planned to maximize the extraction yield; in this case, a comparable efficiency was observed, suggesting that exhaustive EtG extraction was obtained with both approaches. This finding opens new perspectives in the eligible protocols devoted to hair EtG analysis, in terms of speed, automation and reproducibility.
Against Normative Defeat
Authors: Nottelmann Nikolaj 
Published: September 2020

Abstract
Several epistemologists have advanced the idea that a subject’s epistemic status can be weakened by evidence she does not possess but should have possessed, or, alternatively, by beliefs or doubts she should have had under her evidential circumstances but does not have. This alleged phenomenon is known as normative defeat and its adherents have typically reported intuitions that it obtains under mundane circumstances. Some epistemologists have analyzed normative defeat in terms of breached epistemic obligations, while others have preferred an analysis in terms of cognitive malfunctioning. No matter which analysis one prefers, I here argue that - given plausible psychological and epistemological assumptions - if the normative defeat phenomenon were real it would be more bizarre than is generally recognized. I conclude that alleged cases of normatively defeated knowledge or epistemic justification are better analyzed as cases of lucky or undeserved knowledge or epistemic justification.
Efficient DNA double-strand break formation at single or multiple defined sites in theSaccharomyces cerevisiaegenome
Authors: Gnügge Robert , Symington Lorraine S 
Published: September 2020

AbstractDNA double-strand breaks (DSBs) are common genome lesions that threaten genome stability and cell survival. Cells use sophisticated repair machineries to detect and heal DSBs. To study DSB repair pathways and associated factors, inducible site-specific endonucleases have proven to be fundamental tools. In Saccharomyces cerevisiae, galactose-inducible rare-cutting endonucleases are commonly used to create a single DSB at a unique cleavage site. Galactose induction requires cell cultivation in suboptimal growth media, which is tedious especially when working with slow growing DSB repair mutants. Moreover, endonucleases that simultaneously create DSBs in multiple defined and unique loci of the yeast genome are not available, hindering studies of DSB repair in different genomic regions and chromatin contexts. Here, we present new tools to overcome these limitations. We employ a heterologous media-independent induction system to express the yeast HO endonuclease or bacterial restriction enzymes for single or multiple DSB formation, respectively. The systems facilitate tightly controlled and efficient DSB formation at defined genomic sites and will be valuable tools to study DSB repair at a local and genome-wide scale.
BC Cassiopeiae: First detection of IW Andromedae-type phenomenon among post-eruption novae
Authors: Kato Taichi , Kojiguchi Naoto 
Published: September 2020

Abstract
IW And-type dwarf novae are a recently recognized group of cataclysmic variables which are characterized by a sequence of brightening from a standstill-like phase with damping oscillations often followed by a deep dip. We found that the supposed classical nova BC Cas which erupted in 1929 experienced a state of an IW And-type dwarf nova in 2018, 89 yr after the eruption. This finding suggests that a high mass-transfer rate following the nova eruption is associated with the IW And-type phenomenon. The mass of the white dwarf inferred from the decline rate of the nova is considerably higher than the average mass of the white dwarfs in cataclysmic variables, and these massive white dwarfs may be responsible for the manifestation of the IW And-type phenomenon.
Efficacy of early prone or lateral positioning in patients with severe COVID-19: a single-center prospective cohort
Authors: Ni Zhong , Wang Kaige , Wang Ting , Ni Yuenan , Huang Wei , Zhu Ping , Fan Tao , Wang Ye , Wang Bo , Deng Jun , Qian Zhicheng , Liu Jiasheng , Cai Wenhao , Xu Shanling , Du Yu , Wang Gang , Liang Zongan , Li Weimin , Luo Jianfei , Luo Fengming , Liu Dan 
Published: September 2020

Abstract

Background
Position intervention has been shown to improve oxygenation, but its role in non-invasively ventilated patients with severe COVID-19 has not been assessed. The objective of this study was to investigate the efficacy of early position intervention on non-invasively ventilated patients with severe COVID-19.

Methods
This was a single-center, prospective observational study in consecutive patients with severe COVID-19 managed in a provisional ICU at Renmin Hospital of Wuhan University from 31 January to 15 February 2020. Patients with chest CT showing exudation or consolidation in bilateral peripheral and posterior parts of the lungs were included. Early position intervention (prone or lateral) was commenced for &gt; 4 hours daily for 10 days in these patients, while others received standard care.

Results
The baseline parameters were comparable between the position intervention group (n = 17) and the standard care group (n = 35). Position intervention was well-tolerated and increased cumulative adjusted mean difference of SpO2/FiO2 (409, 95% CI 86 to 733) and ROX index (26, 95% CI 9 to 43) with decreased Borg scale (−9, 95% CI −15 to −3) during the first 7 days. It also facilitated absorption of lung lesions and reduced the proportion of patients with high National Early Warning Score 2 (≥ 7) on days 7 and 14, with a trend toward faster clinical improvement. Virus shedding and length of hospital stay were comparable between the two groups.

Conclusions
This study provides the first evidence for improved oxygenation and lung lesion absorption using early position intervention in non-invasively ventilated patients with severe COVID-19, and warrants further randomized trials.
Universality in COVID-19 spread in view of the Gompertz function
Authors: Ohnishi Akira , Namekawa Yusuke , Fukui Tokuro 
Published: September 2020

Abstract
We demonstrate that universal scaling behavior is observed in the current coronavirus (SARS-CoV-2) spread, the COVID-19 pandemic, in various countries. We analyze the numbers of infected people who tested positive (cases) in 11 selected countries (Japan, USA, Russia, Brazil, China, Italy, Indonesia, Spain, South Korea, UK, and Sweden). By using a double exponential function called the Gompertz function, $f_\mathrm{G}(x)=\exp(-e^{-x})$, the number of cases is well described as $N(t)=N_0 f_\mathrm{G}(\gamma(t-t_0))$, where $N_0$, $\gamma$, and $t_0$ are the final number of cases, the damping rate of the infection probability, and the peak time of the daily number of new cases, $dN(t)/dt$, respectively. The scaled data of cases in most of the analyzed countries are found to collapse onto a common scaling function $f_\mathrm{G}(x)$ with $x=\gamma(t-t_0)$ being the scaling variable in the range of $f_\mathrm{G}(x)\pm 0.05$. The recently proposed indicator, the so-called $K$ value, the increasing rate of cases in one week, is also found to show universal behavior. The mechanism for the Gompertz function to appear is discussed from the time dependence of the produced pion numbers in nucleus–nucleus collisions, which is also found to be described by the Gompertz function.
STUDY ON RADON CONCENTRATION VARIATION DURING SUBWAY CONSTRUCTION
Authors: Tan Bo , Yang Guangyuan , Fu Shuhui , Xu Cheng 
Published: September 2020

Abstract
The high radon concentration in the underground space of the subway station during construction often endangers the health of workers. Subway station project No. 16 in Beijing, while under construction, was selected as the main measuring point, a year’s monitoring data was obtained to analyse the change of radon concentration. It was found that the concentration of radon was basically within the range of 5 ~ 500 Bq/m3 and showing a low level in the morning and a high level at noon, and presents the seasonal rule, compared with other seasons, the summer radiation is stronger. Furthermore, among the different measuring points, the radon concentration of the heading roadway is the highest, and the construction level of the station hall is the lowest. According to the comprehensive analysis, the concentration of radon during the construction of the subway station is mainly affected by the ambient temperature and air mobility.
Prevalence and risk factors of Hantavirus infection in patients undergoing hemodialysis in Khartoum, Sudan, in 2019: a cross-sectional study
Authors: Abbas Azza A , Ali Hiba A A , Alagib Mohamed A , Salih Huda F S , Elkhidir Isam M , El Hussein Abdel Rahim M , Enan Khalid A 
Published: September 2020

Abstract

Background
Hantaviruses are enveloped negative sense RNA viruses that cause hemorrhagic fever with renal syndrome. This study aimed to identify the prevalence of Hantavirus IgG antibodies and possible risk factors for Hantaviruses infections among end-stage renal disease (ESRD) patients attending the Dr Salma dialysis center in Sudan.

Methodology
This was a cross-sectional study in which 91 ESRD patients and 30 healthy plasma samples were screened for Hantavirus IgG antibodies using ELISA. A questionnaire containing sociodemographics, history of rat exposure and clinical data information was filled in by each ESRD patient.

Results
In this study, 9 out of 91 ESRD patients (9.9%) tested positive for Hantaviruses antibodies (IgG) while none of the 30 healthy plasma samples showed seropositivity. There was no statistically significant association between age, gender, educational level and rat exposure and Hantavirus infection in ESRD patients (p&gt;0.05)

Conclusion
This study is the first to be conducted in Sudan regarding Hantaviruses and ESRD. The prevalence of Hantavirus antibodies among ESRD patients is high compared with findings reported in the literature from studies conducted on the same group of patients. It points to an interesting question as to whether Hantaviruses have an association with ESRD but further studies are needed before drawing any conclusions.
Morphological phylogeny and review of the generic classification of Colletinae (Hymenoptera: Colletidae)
Authors: Ferrari Rafael R , Packer Laurence 
Published: September 2020

AbstractThe bee subfamily Colletinae includes 542 species, the vast majority of which (518 spp.) belong to Colletes. The generic placement of the remaining 24 species has been controversial, resulting in several classifications being proposed. Despite several recently published molecular phylogenies of Colletinae, it remains unknown (1) what morphological synapomorphies support the recognized genera, (2) in which direction some relevant functional traits (e.g. basitibial plate) have evolved and (3) whether morphology supports the available molecular data. Herein, we provide a morphological phylogeny of Colletinae, which was constructed through parsimony analyses of 186 characters. In total, 50 ingroup species were included representing all major lineages of Colletes (29 spp.), plus all but three of the non-Colletes species of Colletinae (21 spp.). Trees were estimated through equal weights and extended implied weighting. Both provide strong support for the monophyly of Colletinae and indicate that the subfamily is defined by four unique synapomorphies. Our results also confirm recent phylogenetic hypotheses showing that Colletinae can be subdivided into two major clades: one comprising the reciprocally monophyletic Mourecotelles and Xanthocotelles; the other includes Colletes plus Hemicotelles, which are also reciprocally monophyletic. We also provide a fully illustrated key to facilitate generic identification of the Colletinae.
Implementation and maintenance of an established clinical decision support tool algorithm: challenges and recommendations from a prospective cohort study
Authors: Padley Michelle , Madden Tyler , Kothari Parin , Hall Jacob , Pate Matthew J. , Brown Todd 
Published: September 2020

Background:
Computerized clinical decision support systems (CDSS) offer predictive statistical measurements of patient outcomes to clinicians using amalgamated data.

Methods:
The focus of this study was to investigate the usability and reliability of an established CDSS at a pilot site in the management of surgical patients with lumbar degenerative spondylolisthesis, and to assemble recommendations in order to implement a CDSS at other organizations.

Results:
Physicians reported that in 100% of patients, the clinical decision support tool algorithm (CDSTA) could help discuss surgical options. In 78% of patients, physicians agreed that it could help make the decision to recommend surgery. Physicians agreed with the CDSTA outcome predictions in 96% of patients.

Conclusions:
Various challenges were identified concerning CDSTA usability, and the main stumbling point was communication between the clinical and information technology staff who developed the CDSTA, demonstrated through technical language barriers, CDSTA backend updating delays, and reluctance of clinicians and staff to adapt to the CDSTA in addition to the typical daily workflow. The most significant lesson was maintaining open lines of dialogue between the developer and pilot site to allow for seamless CDSS integration into a practice and minimal technical downtime.