bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of combined endoscopic cyanoacrylate injection and balloon-occluded retrograde transvenous occlusion (BRTOcc) of gastrorenal shunts in patients with bleeding gastric fundal varices
Authors: Bazerbachi Fateh , Dobashi Akira , Kumar Swarup , Misra Sanjay , Buttar Navtej S , Wong Kee Song Louis M 
Published: October 2020

Abstract

Background
Endoscopic cyanoacrylate (glue) injection of fundal varices may result in life-threatening embolic adverse events through spontaneous gastrorenal shunts (GRSs). Balloon-occluded retrograde transvenous occlusion (BRTOcc) of GRSs during cyanoacrylate injection may prevent serious systemic glue embolization through the shunt. This study aimed to evaluate the efficacy and safety of a combined endoscopic–interventional radiologic (BRTOcc) approach for the treatment of bleeding fundal varices.

Methods
We retrospectively analysed the data of patients who underwent the combined procedure for acutely bleeding fundal varices between January 2010 and April 2018. Data were extracted for patient demographics, clinical and endoscopic findings, technical details, and adverse events of the endoscopic–BRTOcc approach and patient outcomes.

Results
We identified 30 patients (13 [43.3%] women; median age 58 [range, 25–92] years) with gastroesophageal varices type 2 (53.3%, 16/30) and isolated gastric varices type 1 (46.7%, 14/30) per Sarin classification, and median clinical and endoscopic follow-up of 151 (range, 4–2,513) days and 98 (range, 3–2,373) days, respectively. The median volume of octyl-cyanoacrylate: Lipiodol injected was 7 (range, 4–22) mL. Procedure-related adverse events occurred in three (10.0%) patients, including transient fever, non-life-threatening pulmonary glue embolism, and an injection-site ulcer bleed. Complete gastric variceal obturation was achieved in 18 of 21 patients (85.7%) at endoscopic follow-up. Delayed variceal rebleeding was confirmed in one patient (3.3%) and suspected in two patients (6.7%). Although no procedure-related deaths occurred, the overall mortality rate was 46.7%, primarily from liver-disease progression and co-morbidities.

Conclusion
The combined endoscopic–BRTOcc procedure is a relatively safe and effective technique for bleeding fundal varices, with a high rate of variceal obturation and a low rate of serious adverse events.
The on-premise data sharing infrastructure e!DAL: Foster FAIR data for faster data acquisition
Authors: Arend Daniel , König Patrick , Junker Astrid , Scholz Uwe , Lange Matthias 
Published: October 2020

Abstract

Background
The FAIR data principle as a commitment to support long-term research data management is widely accepted in the scientific community. Although the ELIXIR Core Data Resources and other established infrastructures provide comprehensive and long-term stable services and platforms for FAIR data management, a large quantity of research data is still hidden or at risk of getting lost. Currently, high-throughput plant genomics and phenomics technologies are producing research data in abundance, the storage of which is not covered by established core databases. This concerns the data volume, e.g., time series of images or high-resolution hyper-spectral data; the quality of data formatting and annotation, e.g., with regard to structure and annotation specifications of core databases; uncovered data domains; or organizational constraints prohibiting primary data storage outside institional boundaries.

Results
To share these potentially dark data in a FAIR way and master these challenges the ELIXIR Germany/de.NBI service Plant Genomic and Phenomics Research Data Repository (PGP) implements a “bring the infrastructure to the data” approach, which allows research data to be kept in place and wrapped in a FAIR-aware software infrastructure. This article presents new features of the e!DAL infrastructure software and the PGP repository as a best practice on how to easily set up FAIR-compliant and intuitive research data services. Furthermore, the integration of the ELIXIR Authentication and Authorization Infrastructure (AAI) and data discovery services are introduced as means to lower technical barriers and to increase the visibility of research data.

Conclusion
The e!DAL software matured to a powerful and FAIR-compliant infrastructure, while keeping the focus on flexible setup and integration into existing infrastructures and into the daily research process.
Executive policy development and constitutional norms: Practice and perceptions
Authors: Appleby Gabrielle , Olijnyk Anna 
Published: October 2020

Abstract
Much of the day-to-day work of implementing constitutional law falls to the executive actors. Ministers, policy advisers, public servants, government agencies, government lawyers, and legislative draftspersons develop public policy and legislation within the shadow of the constitution. The first contribution of this article is to advance a normative model to guide the work of these actors. It accepts the primacy of judicial review, but nonetheless supposes significant space for the other branches of government to engage normatively with the constitution. In particular, we argue that areas of constitutional “uncertainty” present the executive with space for particularly lively engagement with the constitution. In these spaces, the executive should have institutional confidence to engage more autonomously with constitutional norms. In such areas, the executive should consider, with appropriate weight, the risk of breach of constitutional norms together with other legitimate influences on policy development, consistent with the executive branch’s institutional mandate. We also argue that key to this understanding of the relationship between the executive, the judiciary, and constitutional norms is one particular, pivotal actor: the government lawyer. The second contribution of this article is its empirically informed study of the constitutional understanding and practice of executive officers. We find considerable evidence of careful executive deliberation in areas of constitutional uncertainty. However, perhaps paradoxically, we also see instances of executive over-cautiousness. Other interviews reveal evidence of constitutional recklessness in the development of new law and policy in areas of constitutional uncertainty. In either of these instances—over-caution or recklessness—we argue executive engagement with constitutional norms is sub-optimal.
Early outcomes of Stanford type A aortic dissection under the coronavirus disease 2019 (COVID-19) pandemic: a multicentre study from Hubei province
Authors: Hu Xingjian , Wang Yin , Liu Junwei , Qiu Xuefeng , Liu Xiaobin , Jiang Xionggang , Huang Xiaofan , Feng Xianqing , Zhang Yulin , Zhang Songlin , Qian Haiyun , Liu Wei , Zhang Jun , Dong Jiashou , Chen Jiajun , Xia Jiahong , Dong Nianguo , Wu Long 
Published: October 2020

Abstract

OBJECTIVES
Our goal was to compare the short-term outcomes of Stanford type A aortic dissection (TAAD), during the coronavirus disease 2019 (COVID-19) pandemic with those during normal times and summarize our perioperative management experience of patients with TAAD in the context of COVID-19.

METHODS
From 17 January 2020 to 8 March 2020, a total of 27 patients with TAAD were operated on in 8 cardiovascular surgery centres in Hubei Province (COVID-19 group). The data from 91 patients with TAAD from the same centres during the same period last year were extracted from the Hubei Cardiac Surgery Registration System (control group). A propensity score matched subgroup of 26 pairs (1:2) was identified. Perioperative data and short-term outcomes were assessed.

RESULTS
Nine patients in the COVID-19 group were categorized as suspicious for the disease (9/27, 33.3%), and others were excluded (18/27, 66.7%). No one was laboratory confirmed preoperatively. The average waiting, cross-clamp and circulatory arrest times were longer in the COVID-19 group (22.9 ± 8.3 vs 9.7 ± 4.0 h, P &lt; 0.001; 135 ± 36 vs 103 ± 45 min, P = 0.003; 24 ± 9 vs 17 ± 8 min, P &lt; 0.001, respectively). The 30-day or in-hospital deaths were 3.8% in both groups (P = 1.0). The COVID-19 group was associated with longer ventilation and intensive care unit times (81 ± 71 vs 45 ± 19 h, P &lt; 0.001; 7.4 ± 3.8 vs 4.5 ± 2.7 days; P &lt; 0.001, respectively). There were no statistical differences between the 2 groups in the incidence of complications such as stroke, neurological deficit, acute kidney injury, pulmonary infection and reoperation. Serum antibody tests for those patients showed 7 out of 9 suspected cases were Immunoglobulin G positive. No cross-infection occurred in other patients or associated medical staff.

CONCLUSIONS
With adequate preparation and appropriate protection, satisfactory early outcomes can be achieved after emergency operations for patients with TAAD during the COVID-19 pandemic.
The Right to Leave Any Country and the Interplay between Jurisdiction and Proportionality in Human Rights Law
Authors: Stoyanova Vladislava 
Published: October 2020

Abstract
This article shows the importance in human rights law of the right to leave any country, in light of increasing efforts by European countries of destination to prevent departures and to contain movement by enlisting countries of origin and transit to act as gatekeepers. The article highlights the autonomous nature of the right and challenges in triggering its application. It assesses whether this right is opposable to destination countries, and finds two key challenges – first, meeting the requisite jurisdictional threshold, and secondly, as this is a qualified right, applying the proportionality test. The article examines the interplay between these difficulties. It argues that the jurisdictional threshold expresses a political and legal relationship between the duty bearer (the State) and the right holders (the individuals). This relationship enables us to operationalize the proportionality test – namely whether measures limiting rights are in accordance with the law and are proportionate.
Genetic analysis of tellurate reduction reveals the selenate/tellurate reductase genes ynfEF and the transcriptional regulation of moeA by NsrR in Escherichia coli
Authors: Fujita Daiki , Tobe Ryuta , Tajima Hirotaka , Anma Yukari , Nishida Ryo , Mihara Hisaaki 
Published: October 2020

Abstract
Several bacteria can reduce tellurate into the less toxic elemental tellurium, but the genes responsible for this process have not yet been identified. In this study, we screened the Keio collection of single-gene knockouts of Escherichia coli responsible for decreased tellurate reduction and found that deletions of 29 genes, including those for molybdenum cofactor (Moco) biosynthesis, iron–sulphur biosynthesis, and the twin-arginine translocation pathway resulted in decreased tellurate reduction. Among the gene knockouts, deletions of nsrR, moeA, yjbB, ynbA, ydaS and yidH affected tellurate reduction more severely than those of other genes. Based on our findings, we determined that the ynfEF genes, which code for the components of the selenate reductase YnfEFGH, are responsible for tellurate reduction. Assays of several molybdoenzymes in the knockouts suggested that nsrR, yjbB, ynbA, ydaS and yidH are essential for the activities of molybdoenzymes in E. coli. Furthermore, we found that the nitric oxide sensor NsrR positively regulated the transcription of the Moco biosynthesis gene moeA. These findings provided new insights into the complexity and regulation of Moco biosynthesis in E. coli.
Widespread Recombination Suppression Facilitates Plant Sex Chromosome Evolution
Authors: Rifkin Joanna L , Beaudry Felix E G , Humphries Zoë , Choudhury Baharul I , Barrett Spencer C H , Wright Stephen I 
Published: October 2020

AbstractClassical models suggest that recombination rates on sex chromosomes evolve in a stepwise manner to localize sexually antagonistic variants in the sex in which they are beneficial, thereby lowering rates of recombination between X and Y chromosomes. However, it is also possible that sex chromosome formation occurs in regions with preexisting recombination suppression. To evaluate these possibilities, we constructed linkage maps and a chromosome-scale genome assembly for the dioecious plant Rumex hastatulus. This species has a polymorphic karyotype with a young neo-sex chromosome, resulting from a Robertsonian fusion between the X chromosome and an autosome, in part of its geographic range. We identified the shared and neo-sex chromosomes using comparative genetic maps of the two cytotypes. We found that sex-linked regions of both the ancestral and the neo-sex chromosomes are embedded in large regions of low recombination. Furthermore, our comparison of the recombination landscape of the neo-sex chromosome to its autosomal homolog indicates that low recombination rates mainly preceded sex linkage. These patterns are not unique to the sex chromosomes; all chromosomes were characterized by massive regions of suppressed recombination spanning most of each chromosome. This represents an extreme case of the periphery-biased recombination seen in other systems with large chromosomes. Across all chromosomes, gene and repetitive sequence density correlated with recombination rate, with patterns of variation differing by repetitive element type. Our findings suggest that ancestrally low rates of recombination may facilitate the formation and subsequent evolution of heteromorphic sex chromosomes.
Clinical, radiologic, and genetic characteristics of histone H3 K27M-mutant diffuse midline gliomas in adults
Authors: Schulte Jessica D , Buerki Robin A , Lapointe Sarah , Molinaro Annette M , Zhang Yalan , Villanueva-Meyer Javier E , Perry Arie , Phillips Joanna J , Tihan Tarik , Bollen Andrew W , Pekmezci Melike , Butowski Nicholas , Oberheim Bush Nancy Ann , Taylor Jennie W , Chang Susan M , Theodosopoulos Philip , Aghi Manish K , Hervey-Jumper Shawn L , Berger Mitchel S , Solomon David A , Clarke Jennifer L 
Published: October 2020

Abstract

Background
“Diffuse midline glioma (DMG), H3 K27M-mutant” is a new tumor entity established in the 2016 WHO classification of Tumors of the Central Nervous System that comprises a set of diffuse gliomas arising in midline structures and is molecularly defined by a K27M mutation in genes encoding the histone 3 variants H3.3 or H3.1. While this tumor entity is associated with poor prognosis in children, clinical experience in adults remains limited.

Methods
Patient demographics, radiologic and pathologic characteristics, treatment course, progression, and patient survival were collected for 60 adult patients with DMG, H3 K27M-mutant. A subset of tumors also underwent next-generation sequencing. Analysis of progression-free survival and overall survival was conducted using Kaplan–Meier modeling, and univariate and multivariate analysis.

Results
Median patient age was 32 years (range 18–71 years). Tumors were centered in the thalamus (n = 34), spinal cord (10), brainstem (5), cerebellum (4), or other midline sites (4), or were multifocal (3). Genomic profiling revealed p.K27M mutations exclusively in the H3F3A gene and an absence of mutations in HIST1H3B or HIST1H3C, which are present in approximately one-third of pediatric DMGs. Accompanying mutations in TP53, PPM1D, FGFR1, NF1, and ATRX were frequently found. The overall survival of this adult cohort was 27.6 months, longer than historical averages for both H3 K27M-mutant DMG in children and IDH-wildtype glioblastoma in adults.

Conclusions
Together, these findings indicate that H3 K27M-mutant DMG represents a heterogeneous disease with regard to outcomes, sites of origin, and molecular pathogenesis in adults versus children.
Bacterial “Virulence” Traits and Host Demographics Predict Escherichia coli Colonization Behaviors Within Households
Authors: Fox Teresa C , Clabots Connie , Porter Stephen B , Bender Tricia , Thuras Paul , Colpan Aylin , Boettcher Jessica , Johnson James R 
Published: October 2020

Abstract

Background
Although intestinal colonization precedes most extraintestinal Escherichia coli infections, colonization-promoting factors are incompletely understood. We compared within-household E. coli colonization patterns with host and bacterial traits.

Methods
Twenty-two veterans with a clinical E. coli isolate and their 46 human and animal household members underwent longitudinal fecal sampling. Distinct E. coli strains were characterized for phylogenetic background, virulence genes, antibiotic resistance, and colonization behaviors. Host and bacterial traits were assessed statistically as predictors of colonization behaviors.

Results
Among the 139 unique-by-household fecal E. coli strains, univariable predictors of colonization behavior included (i) host demographics, (ii) matching the index clinical isolate, and (iii) bacterial characteristics (2 phylogroups, 5 clonal lineages, 18 virulence genes, and molecular extraintestinal pathogenic E. coli status). Multivariable predictors of colonization behavior included veteran host, spouse host, matching the index clinical isolate, phylogroup F, ST73, hlyD (alpha hemolysin), hlyF (variant hemolysin), H7 fliC (flagellar variant), vat (vacuolating toxin), and iha (adhesin-siderophore).

Conclusions
Host demographics, multiple bacterial “virulence” traits, and matching the index clinical isolate predicted E. coli fecal colonization behaviors. Thus, certain bacterial characteristics may promote both colonization and pathogenicity. Future interventions directed toward such traits might prevent E. coli infections both directly and by disrupting antecedent colonization.
Chapter 1
Authors: Glancy Mark 
Published: October 2020

Abstract
Chapter 1 covers the years 1904 to 1915, from Archie Leach’s birth through his childhood to age 11. It offers information on the city of his birth, Bristol, and it considers his extended family’s background. It is revealed that his mother’s side of the family, the Kingdons, were particularly troubled and impoverished: his maternal grandfather died in the workhouse, his aunt was committed to a workhouse and subsequently the Bristol Lunatic Asylum, and one of his uncles spent his adolescence in a borstal-like facility. It also considers his mother’s aspirational nature and his parents’ unhappy marriage, which culminated in his mother’s disappearance just after his 11th birthday.
Chapter 3
Authors: Glancy Mark 
Published: October 2020

Abstract
Covering the years 1918 to 1922, and taking Archie from 14 to 18 years old, this chapter explores the reasons Archie ran away from home and joined the Pender Troupe of acrobats at age 14. It explains the nature of the troupe’s act and Archie’s training as a stilt-walker and gymnast. It offers details about their tours of Britain, their home base in Brixton (south London), their move to New York to join the show Good Times (1920), and their subsequent tour of North America. It explores Archie’s relationship with Bob and Margaret Pender, who became surrogate parents to him, and also his burgeoning friendship with the American comedian Don Barclay.
Chapter 7
Authors: Glancy Mark 
Published: October 2020

Abstract
In 1932, Cary Grant had his first major role in a high profile film, working with the famed star-director team Josef von Sternberg and Marlene Dietrich in Blonde Venus (1932). Chapter 7 explores the making of this classic film, and Cary Grant’s discomfort working alongside these two very temperamental personalities. It considers the crucial element that von Sternberg brought to Cary Grant’s image: his razor sharp hair parting. It also offers accounts of the making of Hot Saturday (1932) and Madame Butterfly (1932), and, in the process, the slow but steady improvement in Grant’s acting and on-screen presence.
Chapter 8
Authors: Glancy Mark 
Published: October 2020

Abstract
This chapter considers the burgeoning relationship between Cary Grant and the actress Virginia Cherrill, who would become his first wife. It explains Cherrill’s background, her prominent role in Charlie Chaplin’s City Lights (1931), and his intense and at times impulsive attraction to her. The chapter offers an account of the making of She Done Him Wrong (1932) and considers why Cary Grant disliked the film’s star, Mae West, so much. In later years, West often said that she “discovered” Cary Grant, a claim he vehemently denied, but there is no doubt that She Done Him Wrong, together with the next film that he made with West, I’m No Angel (1933), were the only box-office hits from this period of his career. The chapter reviews the other films from this period—The Woman Accused (1933), The Eagle and the Hawk (1933), and Gambling Ship (1933)—and considers why they failed to win favour with critics and audiences.
Chapter 13
Authors: Glancy Mark 
Published: October 2020

Abstract
In 1937, Cary Grant’s career as a freelance star began with three screwball comedies that established him as the master of this genre. Topper (1937), made by the independent producer Hal Roach, initiated this sharp upturn in his career. This stylish screwball comedy brought out a new playful, wry, ironic dimension in Grant’s performance style. Improvisation on the set was key to his new screen persona, and he was given even greater reign to improvise in his first Columbia film, Leo McCarey’s The Awful Truth (1937). Legend has it that he was uncomfortable working with McCarey, but McCarey helped him to mould the Cary Grant star persona, unique for combining debonair and slapstick qualities. He signed a contract with Columbia Pictures that gave him the power to choose which films he made, and control over both his publicity and his wardrobe, but it was a non-exclusive contract, allowing him to make his next film at RKO Pictures. In Bringing Up Baby (1938), director Howard Hawks encouraged a frenzied edge to his performance. This is perfectly exemplified in the famous scene in which Grant leaps in the air, shouting “I just went gay all of the sudden”—a line he improvised on the set and one that demonstrates the liberated, unconventional mores of screwball comedy. Bringing Up Baby had a mixed reception on first release in 1938, but in later years, through repeated revivals and screenings on television, it became one of his best known and most admired films.
Chapter 20
Authors: Glancy Mark 
Published: October 2020

Abstract
The immediate post-war years saw Cary Grant’s box-office drawing power stronger than ever before. Jack Warner had bought out his contract with Columbia so that Grant could play the songwriter Cole Porter in the musical biopic Night and Day (1946). His first Technicolor film, Night and Day is bright and breezy, and it is filled with popular songs. The production, however, was troubled. Grant and director Michael Curtiz were in constant conflict. Grant was much happier working with Alfred Hitchcock and co-star Ingrid Bergman on the next film, Notorious (1946). These three became lifelong friends while making this wonderfully dark, gothic, spy story. Hitchcock was so keen on the darker side of the Cary Grant star persona that he proposed making a film of Hamlet with him, but legal complications prevented this. Grant then had a hiatus from filmmaking that allowed him to travel to Bristol for the first time since 1939. There, he saw his mother and also the terrible damage the city suffered during the blitz. He returned to make one of his most frivolous films, The Bachelor and the Bobby-Soxer (1947), with Myrna Loy and the child-star turned teenager Shirley Temple. This light-as-a-feather screwball comedy continued his box-office winning streak.