bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autophagy and Ubiquitination as Two Major Players in Colorectal Cancer: A Review on Recent Patents
Authors: Saffari-Chaleshtori Javad , Asadi-Samani Majid , Rasouli Maryam , Shafiee Sayed Mohammad 
Published: June 2020

Background:
As one of the most commonly diagnosed cancers among men and women,
Colorectal Cancer (CRC) leads to high rates of morbidity and mortality across the globe. Recent anti-
CRC therapies are now targeting specific signaling pathways involved in colorectal carcinogenesis.
Ubiquitin Proteasome System (UPS) and autophagy are two main protein quality control systems,
which play major roles in the carcinogenesis of colorectal cancer. A balanced function of these
two pathways is necessary for the regulation of cell proliferation and cell death.

Objective:
In this systematic review, we discuss the available evidence regarding the roles of autophagy
and ubiquitination in progression and inhibition of CRC.

Methods:
The search terms “colorectal cancer” or “colon cancer” or “colorectal carcinoma” or
“colon carcinoma” in combination with “ubiquitin proteasome” and “autophagy” were searched in
PubMed, Web of Science, and Scopus databases, and also Google Patents (https://patents.google
.com) from January 2000 to Feb 2020.

Results:
The most important factors involved in UPS and autophagy have been investigated. There
are many important factors involved in UPS and autophagy but this systematic review shows the
studies that have mostly focused on the role of ATG, 20s proteasome and mTOR in CRC, and the
more important factors such as ATG8, FIP200, and TIGAR factors that are effective in the regulation
of autophagy in CRC cells have not been yet investigated.

Conclusion:
The most important factors involved in UPS and autophagy such as ATG, 20s proteasome
and mTOR, ATG8, FIP200, and TIGAR can be considered in drug therapy for controlling or
activating autophagy.
Histone Deacetylase Inhibitor Trichostatin A Suppresses Cell Proliferation and Induces Apoptosis by Regulating the PI3K/AKT Signalling Pathway in Gastric Cancer Cells
Authors: An Xinli , Wei Zekun , Ran Botian , Tian Hao , Gu Hongyu , Liu Yan , Cui Hongjuan , Zhu Shunqin 
Published: June 2020

Background:
Gastric cancer, a common malignant tumour worldwide, has a relatively poor prognosis
and is a serious threat to human health. Histone Deacetylase Inhibitors (HDACi) are anticancer agents that are
known to affect the cell growth of different cancer types. Trichostatin A (TSA) selectively inhibits the class I
and II mammalian Histone Deacetylase (HDAC) family enzymes and regulates many cell processes. Still, the
underlying mechanisms of HDACs are not fully understood in gastric cancer.

Objective:
This study aims to investigate the antitumor effect and the mechanism of growth modulation of gastric
cancer cells by TSA.

Methods:
The cell proliferation of gastric cancer cells was measured by MTT and BrdU immunofluorescence
assays. Soft agar assay was used to detect the colony formation ability of gastric cancer cells. Flow cytometry was
used to examine cell cycle and apoptosis. Western blot was employed to detect protein expression of target factors.

Results:
TSA inhibits the proliferation of MKN-45 and SGC-7901 cells and leads to significant repression of
colony number and size. Flow cytometry assays show TSA induces cell cycle arrest at G1 phase and apoptosis,
and TSA effects the expression of related factors in the mitochondrial apoptotic signalling and cell cycle-related
regulatory pathways. Furthermore, TSA increased histone H3K27 acetylation and downregulated the expression
of PI3K and p-AKT.

Conclusion:
Downregulating PI3K/AKT pathway activation is involved in TSA-mediated proliferation inhibition
of gastric cancer.
Cola Nitida (Kola Nuts) Attenuates Hepatic Injury in Type 2 Diabetes by Improving Antioxidant and Cholinergic Dysfunctions and Dysregulated Lipid Metabolism
Authors: Erukainure Ochuko L. , Sanni Olakunle , Salau Veronica F. , Koorbanally Neil A. , Islam Md. Shahidul 
Published: June 2020

Background:
The therapeutic effect of Cola nitida hot infusion against diabetes hepatic
injury was investigated in livers of diabetic rats. Cola nitida was infused in boiling water and concentrated.

Methods:
The concentrated infusion was administered to T2D rats at low and high doses (150 and 300
mg/kg body weight (bw), respectively). The normal group (positive control) and another diabetic group
(negative control) were administered distilled water, while metformin served as the standard drug. A
toxic group that consists of normal rats administered a high dose of C. nitida. After 6 weeks, the rats
were sacrificed, and their livers were collected. They were assayed for oxidative stress markers, myeloperoxidase,
acetylcholinesterase and ATPase activities. Hepatic lipid metabolites were profiled with
GC-MS and their metabolic pathways were analyzed using the MetaboAnalyst 4.0 online server.

Results:
Treatment with C. nitida caused a significant elevation of glutathione level and SOD activity,
while concomitantly inhibiting lipid peroxidation, myeloperoxidase, acetylcholinesterase and ATPase
activities in hepatic tissues of the rats. Treatment with C. nitida also caused significant depletion of
diabetes-generated lipid metabolites, with concomitant generation of fatty esters and steroids as well as
inactivation of diabetes-activated pathways.

Conclusion:
These data demonstrate the therapeutic effect of C. nitida against diabetic hepatotoxicity
in diabetic rats.
Incidental Findings in Temporomandibular Joint Region Detected by Cone-beam Computed Tomography: A Retrospective Study
Authors: Mehdizadeh Mojdeh , Rezaei Zahra , Moghadam Farida Ghazanfari 
Published: June 2020

Purpose:The purpose of this study was to investigate the prevalence of Incidental Findings (IFs) in the temporomandibular joint (TMJ) region detected in Cone-Beam Computed Tomography (CBCT) scans of maxilla and mandible.Materials and Methods:In this study, 384 CBCT scans were reviewed for IFs of the TMJ region. Demographic data including age and sex were recorded. The scans were evaluated in multiplanar views: corrected sagittal, corrected coronal and axial sections. IFs in TMJ region were categorized into eight groups: osteoarthritis, flattening and erosion of condyle and articular eminence, osteophytes, subchondral pseudocyst, condyle hyperplasia, condyle hypoplasia, bifid condyle, and soft tissue calcification. Statistical analyses were performed using the SPSS statistic v.22.Results:From the CBCT scans, a total of 81 (21.1%) IFs were identified. 184 of the subjects (47.9%) were male and 200 (52.1%) were females. Their age ranged from 10 to 75 years old with a mean of 36.8 and a standard deviation of 13.9 years. The most frequent IFs were flattening and erosion of condyle and articular eminence (40.74%), followed by soft tissue calcification (30.86%). Osteoarthritis was not observed in any of the subjects. There was no significant difference between females and males in IFs of TMJ joint and its related structures. Flattening and erosion of condyle and articular eminence, soft tissue calcification, osteophytes and, subchondral pseudo cyst showed significant differences between individuals of different age ranges.Conclusion:While examining CBCT images, it is critical to check for evidence of IFs in the TMJ region. The findings of this study emphasize the value of a thorough examination of all areas visualized on CBCT scans even those beyond the region of interest.
An Effective Congestion Control Algorithm based on Traffic Assignment and Reassignment in Wireless Sensor Network
Authors: Wang Chao 
Published: June 2020

Background:
It is important to improve the quality of service by using congestion detection
technology to find the potential congestion as early as possible in wireless sensor network.

Methods:
So an improved congestion control scheme based on traffic assignment and reassignment
algorithm is proposed for congestion avoidance, detection and mitigation. The congestion area of
the network is detected by predicting and setting threshold. When the congestion occurs, sensor
nodes can be recovery quickly from congestion by adopting reasonable method of traffic reassignment.
And the method can ensure the data in the congestion areas can be transferred to noncongestion
areas as soon as possible.

Results:
The simulation results indicate that the proposed scheme can reduce the number of loss
packets, improve the throughput, stabilize the average transmission rate of source node and reduce
the end-to-end delay.

Conclusion:
: So the proposed scheme can enhance the overall performance of the network. Keywords:
wireless sensor network; congestion control; congestion detection; congestion mitigation;
traffic assignment; traffic reassignment.
Arte pública urbana e comunicação turística
Authors: Andrade Pedro 
Published: June 2020

O presente texto, por um lado, visa descortinar alguns dos debates recentes sobre a arte
pública urbana, e as suas práticas mais criativas. Nesta perspetiva, apresenta-se um estudo de
caso ilustrativo sobre o Iminente Festival enquanto interculturalidade imanente à arte pública.
Em seguida, discute-se a e-arte pública, ou seja, a arte pública que é produzida e partilhada no
ciberespaço e no cibertempo. Depois, estas iniciativas artísticas são confrontadas com controvérsias,
clássicas e atuais, acerca das culturas móveis como o turismo e, em especial, o processo
da comunicação turística. Novas epistemologias e metodologias sociológicas encontram-se
igualmente abordadas, e exemplificadas com a Sociologia Artística, a Hibridologia e a Banda
Desenhada Sociológica. Finalmente, um breve glossário busca sintetizar e definir alguns conceitos
sociológicos que circunscrevem processos sociais centrais, subjacentes à articulação e
hibridação entre a arte pública urbana e a comunicação turística.
Mover o olhar sobre circulações da arte e receção
Authors: Conde Idalina 
Published: June 2020

Contribuição sobre culturas móveis, este texto aborda circulações físicas, visuais e imaginárias
da arte com passagem do museu e de exposições para o espaço público. Assim, arte de
indoors para outdoors com mutações que atravessam os quadros da visitabilidade, semiologia,
mediações e modos de perceção versus receção. Algumas recriações de Las Meninas de Diego
Velázquez e Zodiac Heads/Circle of Animals de Ai Weiwei são exemplos em contraponto que ilustram
a problemática da mobilidade, com metamorfoses e itinerâncias. Mover o olhar significa
seguir essas viagens como um salto interpretativo sobre contextos e relações com a arte.
Pengimplementasian e-modul etnokonstruktivisme terhadap motivasi belajar peserta didik Kelas V sekolah dasar
Authors: Kurniawati Eka Feri 
Published: June 2020

Penelitian ini bertujuan untuk mengembangkan produk bahan ajar berupa modul pembelajaran. Modul pembelajaran dibuat dalam bentuk eletronik modul atau e-modul dengan dengan berbasis etnokonstruktivisme. Penelitian ini megadopsi model dari Branch yaitu ADDIE (Analyze, Design, Development, Implementation, dan Evaluation). Subjek dari penelitian ini adalah peserta didik kelas V SD Negeri No.80/I Muara Bulian yang berjumlah 28 orang. Hasil dari penelitian ini digunakan untuk melihat kelayakan dan motivasi peserta didik terhadap e-modul yang dikembangkan dan untuk mengetahui motivasi peserta didik. Hasil data yang diperoleh menunjukkan dari 28 responden yang mengisi angket motivasi menunjukkan bahwa frekuensi terbesar sebanyak 19 dengan presentase 67.8% termasuk ke dalam kategori Baik. Hasil dari penelitian ini menunjukkan bahwa e-modul berbasis etnokonstruktivisme layak untuk dikembangkan dan digunakan sebagai tambahan bahan ajar guna mendukung kegiatan pembelajaran untuk membantu menumbuhkan motivasi belajar peserta didik.
Upaya meningkatkan minat belajar pelajaran seni budaya melalui model discovery learning dengan media puzzle
Authors: Kasmiatun Kasmiatun 
Published: June 2020

Best practice ini bertujuan untuk meningkatkan minat belajar siswa pelajaran seni budaya terhadap materi ragam hias pada bahan alam (kayu) menggunakan model discovery learning dengan media puzzle. Karya tulis ini menceritakan pengalaman terbaik guru dalam menyelesaikan sebuah permasalahan pembelajaran di kelasnya. Hasil analisis data nilai minat belajar siswa menunjukkan adanya peningkatan minat belajar siswa yaitu nilai persentase klasikal minat belajar siswa 89% dengan kategori 94% tinggi yang berdampak pada nilai hasil belajar siswa sehingga mengalami peningkatan dengan nilai rata-rata kelas 92% dan ketuntasan klasikal 87.5%. Kesimpulan best practice ini adalah bahwa penggunaan model discovery learning dengan media puzzle dapat meningkatkan minat belajar siswa pelajaran seni budaya terhadap materi ragam hias pada bahan alam (kayu) di kelas VII A SMP Negeri 1 Teluk Bayur.
Pemilihan Media Pembelajaran Terbaik Sebagai Sarana Pembelajaran yang Efektif Menggunakan Metode SAW
Authors: Trisnawati Trisnawati , Puastuti Dwi , Sholeha Lutvia 
Published: June 2020

Dalam menentukan media pembelajaran bagi anak PAUD dan TK, guru harus memiliki kreativitas yang tinggi dan wawasan yang luas. Jumlah PAUD dan TK yang ada di kecamatan pringsewu ada 52 dan penelitian dilakukan di salah satu PAUD yang ada di kecatamatan pringsewu yaitu PAUD AL HADDII. Sistem pendukung keputusan bisa menjadi cara alternatife yang interaktif guna membantu mengambil keputusan melalui data dan informasi. Metode Simple Addtive Weighting (SAW) dapat membantu dalam pengambilan keputusan suatu masalah dalam perhitungan.akan tetapi perhitungan dengan menggunakan metode Simple additive weighting ini hanya akan menghasialkan nilai terbesar yang akan terpilih sebagai alternatif terbaik. Perhitungan akan sesuai dengan metode ini apabila alternatif yang terpilih memenuhi kriteria yang telah ditentukan. Dengan demikian melakukan perankingan terhadap bobot nilai yang diambil dari criteria C1audio,C2 Visual,C3 audio visual, C4lingkungan, C5 permainan, C6 seni rupa. Dari hasil tiga alternative yang diuji didapatkan nilai dari hasil A1 = 67, A2 = 91.5, A3= 92, dengan nilai terbesar ada pada A3 sehingga A3 yaitu kurikulum 2013. Media pembelajaran nya adalah music, gambar, dongeng, keluarga, membangun menara, dan kolase. dapat dikatakan sebagai media pembelajaran Terbaik. Manfaat yang ingin dicapai dari penelitian adalah untuk meningkatkan kulitas hasil belajar anak,proses pembelajaran menjadi lebih jelas dan menarik , dan dalam penyampaian materi pembelajaran dapat disamaratakan.
Analysis of the links between endothelium-dependent vasodilation indicators and the levels of high-sensitivity C-reactive protein and fractalkine/CX3CL1 in patients with acute coronary syndrome
Authors: Polunina E. A. , Kuzmichev K. Yu. , Voronina L. P. , Polunina O. S. , Sevostyanova I. V. 
Published: June 2020

Objective: to study and analyze the links between endothelium-dependent vasodilation (EDV) indicators and the levels of fractalkine (FN/CX3CL1) and high sensitivity C-reactive protein (hs-CRP) in patients with acute coronary syndrome (ACS).Materials and methods: among the examined individuals with ACS, 63 patients had acute myocardial infarction (MI); 41 patients had unstable angina (UA), represented by first – time angina in 15 people and 26 people had progressive angina. Control group included 20 healthy control individuals. Pharmacological test with 5% acetylcholine (AcH) was used to assess the functional state of the vascular endothelium. Enzyme-linked immunosorbent assay was used to determine the levels of FN/CX3CL1 and hs-CRP.Results: all the examined patients with ACS showed statistically significant changes in EDV indicators compared to the control group, as well as an increase in the level of FN/CX3CL1 and hs-CRP. The most pronounced changes of the values of EDV indicators and the levels of FN/CX3CL1 and hs-CRP, from the examined patients, were detected among patients with acute MI. Th e presence of correlations between the studied indicators was revealed. Th e strength of the identified links was greater among patients with acute MI, compared to patients with UA. Th e strength of the links found in patients with both UA and acute MI was greater between EDV indicators and FN/CX3CL1 levels, than between EDV indicators and hs-CRP levels.Conclusions:all the examined patients with ACS had the EDV disorders associated with the severity of systemic infl ammation. In the group of patients with acute MI, the severity of EDV disorders was greater than in patients with UA, which was apparently due to the infl uence of the resorption-necrotic syndrome, which potentiates increased systemic infl ammation and damage to the endothelium of microvessels with EDV disorders, which was confirmed by the results of correlation analysis. A positive link was found between the levels of FN/CX3CL1 hs-CRP.
On the histological structure of Kaposi’s sarcoma
Authors: Derizhanova I. S. , Balyshev O. O. 
Published: June 2020

Objective: to study the histological structure of various types of Kaposi’s sarcoma and the morphogenetic potentials of vascular cells in the tumor growth.Materials and methods: results of the histological examination of Kaposi’s sarcoma from 5 patients have been analyzed: biopsies of the skin and subcutaneous tissue from 3 HIV-infected patients (2 men and 1 woman) and 1 man, a participator of the liquidation (dosimetrist) of the consequences of the Chernobyl accident in 1986. The tumor nodes of the Kaposi’s sarcoma of the stomach, lymphatic mesenteric node and dura mater of a 41-year-old woman who had died aft er allogeneic kidney transplantation due to glomerulonephritis were also examined while the skin was intact. Histological preparations were stained with hematoxylin and eosin, picrofuchsin according to Van Gieson, alcian blue and impregnated with silver according to Bilshovsky.Results: it was confirmed that Kaposi’s sarcoma is the part of a multicentrally occurring viral lesion of the skin, subcutaneous tissue and internal organs caused by herpes infections of the 8th type on the background of immunosuppression. The entire process of tumor formation includes, besides the tumor growth, pre-tumor conditions (viral infection, chronic inflammation), and pre-tumor processes (intravascular neoplasia of low and high degree), which determining the diversity of the histological structure, clinical course, outcomes of neoplasms and complicates the correct diagnosis. The morphogenetic potentialities of endothelial and perithelial cells which make various variants of angiomatous structures, and also form spindle cell, myofibroblastic and fi broblastic components, are also important.Conclusions: the fifth, not yet described in the literature, variant of Kaposi’s sarcoma is highlighted - radiation, due to exposure of radiation energy.
About the characteristics of «internal» and «external» epidemiological risks in the territory Rostov region
Authors: Kononenko A. A. , Vodyanitskaya S. S. 
Published: June 2020

Objective: to identify some «internal» and «external» risks that are signifi cant for the Rostov region and calculate their quantitative characteristics.Materials and methods: materials for «internal» risks in the administrative territories of the Rostov region served materials FBUZ «Center of hygiene and epidemiology in the Rostov region» on the incidence of Crimean hemorrhagic fever (KGL) and West Nile (LSN) during the period 2004 – 2017 as a whole across the Rostov region and the slit regions, the data of the regional law «About administrative-territorial structure of Rostov region», the Results of the national census. To determine the «internal» risks, we used the guidelines developed by us «Methodology for assessing the territory of the subject of the Russian Federation on the integral indicator of population morbidity with arbovirus infections», approved by Th e decision of the Academic Council of the Rostov-on-Don anti-plague Institute of Rospotrebnadzor and approved by the Director.Results: based on the results of the ranking of the territory of the Rostov region on the incidence of KGL and LDL, the degree of epidemiological risk was assessed and «risk territories» were identifi ed for these nosologies, which can serve as a basis for risk management — making scientifi cally based management decisions. To calculate the magnitude of the «external» risk and further spread of the disease, you can use various methods to assess the probability of adverse development of the epidemiological situation under the infl uence of various risk factors. Epidemiological risk can also be characterized by multiplying the individual risk by the population exposed to risk factors.Conclusions: identifi cation and calculation of risk levels depending on risk factors will help determine the scope of management decisions, and the specifi cation of risk factors will allow you to develop specifi c measures to reduce risk.
Adipokine profi le in patients with ischemic heart disease in stenting of the coronary arteries: contribution of changes in psychoemotional status
Authors: Lobe A. O. , Ivanchenko D. N. , Dorofeeva N. P. , Sizyakina L. P. , Kharitonova M. V. , Shlyk S. V. 
Published: June 2020

Objective: to investigate the adipokine profile’s changes, depending on the presence or absence the signs of psychoemotional disorders in the form of associated affective symptoms in patients with stable coronary heart disease (CHD) without diagnosed carbohydrate metabolism’s disorders undergoing routine percutaneous coronary intervention (PCI) with stenting, and also to assess their relationship with clinical outcomes within 1 year after hospitalization.Materials and methods: the study included 20 male patients with stable angina pectoris of functional classes II – III, hospitalized for coronary stenting. The severity of affective symptoms were being assessed. The levels markers of adiponectin, leptin, resistin in the blood plasma were determined before PCI and on the 3rd day after the operation.Results: patients with stable coronary artery disease had increase in resistin concentrations and a decrease in adiponectin levels compared with reference. The change of psychoemotional status was accompanied by an initially more expressed increase in the concentrations of plasma resistin. The resistin’s level has been signifi cantly increased on the third day after PCI in patients without depressive symptoms. The dynamics of depressive symptoms hasn’t observed during the year. Clinically unfavorable outcomes, including stent’s restenosis, re-hospitalization, and the increase in angina attacks, were recorded more oft en in patients with subclinical symptoms of depression that persisted throughout the observation period.Conclusions: the factors that negatively aff ected the cardiac prognosis were the disorders of the psychoemotional status and adipokine’s changes, including аn increasе of resistin’s and a decrease of adiponectin’s levels.