bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing the genes and pathways related to major depressive disorder via a systems biology approach
Authors: Fan Ting , Hu Ying , Xin Juncai , Zhao Mengwen , Wang Ju 
Published: December 2019

AbstractIntroductionMajor depressive disorder (MDD) is a mental disorder caused by the combination of genetic, environmental, and psychological factors. Over the years, a number of genes potentially associated with MDD have been identified. However, in many cases, the role of these genes and their relationship in the etiology and development of MDD remains unclear. Under such situation, a systems biology approach focusing on the function correlation and interaction of the candidate genes in the context of MDD will provide useful information on exploring the molecular mechanisms underlying the disease.MethodsWe collected genes potentially related to MDD by screening the human genetic studies deposited in PubMed (https://www.ncbi.nlm.nih.gov/pubmed). The main biological themes within the genes were explored by function and pathway enrichment analysis. Then, the interaction of genes was analyzed in the context of protein–protein interaction network and a MDD‐specific network was built by Steiner minimal tree algorithm.ResultsWe collected 255 candidate genes reported to be associated with MDD from available publications. Functional analysis revealed that biological processes and biochemical pathways related to neuronal development, endocrine, cell growth and/or survivals, and immunology were enriched in these genes. The pathways could be largely grouped into three modules involved in biological procedures related to nervous system, the immune system, and the endocrine system, respectively. From the MDD‐specific network, 35 novel genes potentially associated with the disease were identified.ConclusionBy means of network‐ and pathway‐based methods, we explored the molecular mechanism underlying the pathogenesis of MDD at a systems biology level. Results from our work could provide valuable clues for understanding the molecular features of MDD.
Retinal sublayer defect is independently associated with the severity of hypertensive white matter hyperintensity
Authors: Qu Man , Kwapong William Robert , Peng Chenlei , Cao Yungang , Lu Fan , Shen Meixiao , Han Zhao 
Published: December 2019

AbstractPurposeTo investigate the association of specific retinal sublayer thicknesses on optical coherence tomography (OCT) imaging with brain magnetic resonance imaging (MRI) markers using the Fazekas scale in hypertensive white matter hyperintensity (WMH) subjects.MethodsEighty‐eight participants (32 healthy controls and 56 hypertensive white matter hyperintensity subjects) underwent retinal imaging using the OCT and MRI. A custom‐built algorithm was used to measure the thicknesses of the retinal nerve fiber layer (RNFL) and ganglion cell layer and inner plexiform layer (GCIP). Focal markers for white matter hyperintensities were assessed on MRI and graded using the Fazekas visual rating.ResultsHypertensive WMH showed significantly reduced (p < .05) RNFL and GCIP layers when compared to healthy controls, respectively. A significant correlation was found between the RNFL (ρ = −.246, p < .001) and GCIP (ρ = −.338, p < .001) of the total participants and the Fazekas score, respectively. Statistical differences were still significant (p < .05) when correlations were adjusted for intereye correlation, age, hypertension, smoking, body mass index, and diabetes. Among the cases of hypertensive WMH, higher Fazekas scores were significantly associated (p < .05) with the thinning of both the RNFL and GCIP layers after adjustment of age and other risk factors.ConclusionsRetinal degeneration in the RNFL and GCIP was independently associated with focal lesions in the white matter of the brain and deteriorates with the severity of the lesions. We suggest that imaging and measurement of the retinal sublayers using the OCT may provide evidence on neurodegeneration in WMH.
The association between DXA‐derived body fat measures and breast cancer risk among postmenopausal women in the Women's Health Initiative
Authors: Arthur Rhonda S. , Xue Xiaonan , Kamensky Victor , Chlebowski Rowan T. , Simon Michael , Luo Juhua , Shadyab Aladdin H. , Neuhouser Marian L. , Banack Hailey , Ho Gloria Y. F. , Lane Dorothy S. , Pan Kathy , Reding Kerryn W. , Wassertheil‐Smoller Sylvia , Dannenberg Andrew J. , Rohan Thomas E. 
Published: December 2019

AbstractBackgroundMost studies demonstrating an association between excess adiposity and postmenopausal breast cancer have used anthropometric measures, particularly body mass index (BMI). However, more direct body fat measures may more accurately determine the relationship between body fat distribution and breast cancer risk.MethodsCox proportional hazards regression models were created to examine the associations of dual‐energy x‐ray absorptiometry (DXA) body fat measures (at baseline and during follow‐up) with breast cancer risk among 10 931 postmenopausal women from the Women's Health Initiative cohort. A total of 639 incident invasive breast cancer cases (including 484 estrogen receptor positive (ER+) cases) were ascertained after a median follow‐up of 15.0 years.ResultsExcess whole body fat mass and trunk fat mass were positively associated with risk invasive breast cancer risk. These associations persisted even after additional adjustment for standard anthropometric measures. In time‐dependent analyses, we observed that both whole body fat mass and trunk fat mass, in the highest versus lowest category, were associated with a doubling of risk of invasive breast cancer overall (HR: 2.17; 95% CI: 1.54‐3.05 and 2.20; 1.55‐3.14, respectively) and of ER+ breast cancer (2.05; 1.37‐3.05 and 2.03; 1.34‐3.07, respectively). The remaining DXA measures were also positively associated with breast cancer risk in baseline and time‐dependent analyses.ConclusionThese findings suggest that DXA‐derived body fat measures are positively associated with breast cancer risk after adjustment for BMI and other conventional breast cancer risk factors.
Cadmium Sulfide Quantum Dots–Organometallic Halide Perovskite Bilayer Electrode Structures for Supercapacitor Applications
Authors: Oloore Luqman E. , Gondal Mohammed A. , Popoola Idris K. , Popoola AbdulJelili 
Published: December 2019

AbstractSupercapacitors are attracting great attention because of their fast charging–discharging ability as well as their high power density. The current research in this area focuses mainly on exploring novel low‐cost electrode materials with higher energy and power densities. In this work, thin‐film electrochemical capacitors were fabricated using layers of self‐synthesized cadmium sulfide quantum dots and organometallic halide perovskite materials as active electrodes. Organometallic halide perovskites exhibit interesting ionic responses as well as extraordinary electronic properties. These properties are exploited in fabricating the electrochemical capacitors, and the devices showed excellent cycling ability with stable capacitance outputs beyond 4000 cycles. Impedance spectroscopy measurements revealed that perovskites do not only serve as active electrodes but also as solid electrolytes, thereby enhancing the capacitance of the devices and hence the energy densities. The layers provide high surface areas for electrolytes to access the electrode materials; reasonably low charge transfer resistance and small relaxation time were also observed. This work opens new opportunities for developing thin‐film supercapacitors using low‐cost electrode materials and employing a facile, inexpensive solution‐process coating.
Electrophotocatalytic Undirected C−H Trifluoromethylations of (Het)Arenes
Authors: Qiu Youai , Scheremetjew Alexej , Finger Lars H. , Ackermann Lutz 
Published: December 2019

AbstractElectrophotochemistry has enabled arene C−H trifluoromethylation with the Langlois reagent CF3SO2Na under mild reaction conditions. The merger of electrosynthesis and photoredox catalysis provided a chemical oxidant‐free approach for the generation of the CF3 radical. The electrophotochemistry was carried out in an operationally simple manner, setting the stage for challenging C−H trifluoromethylations of unactivated arenes and heteroarenes. The robust nature of the electrophotochemical manifold was reflected by a wide scope, including electron‐rich and electron‐deficient benzenes, as well as naturally occurring heteroarenes. Electrophotochemical C−H trifluoromethylation was further achieved in flow with a modular electro‐flow‐cell equipped with an in‐operando monitoring unit for on‐line flow‐NMR spectroscopy, providing support for the single electron transfer processes.
A Flexible Strategy for Modular Synthesis of Curcuminoid‐BF2/Curcuminoid Pairs and Their Comparative Antiproliferative Activity in Human Cancer Cell Lines
Authors: Abonia Rodrigo , Laali Kenneth K. , Raja Somu Dawn , Bunge Scott D. , Wang Esther C. 
Published: December 2019

AbstractA facile protocol that enables synthetic interconversion of CUR‐BF2 and CUR compounds is described that significantly widens the preparative scope of curcuminoids, providing access to larger libraries of compounds, thus enabling comparative antiproliferative and apoptotic study of a larger library of synthetic analogs in cancer cell lines.
Complex Pore Structure of Mesoporous Zeolites: Unambiguous TEM Imaging Using Platinum Tracking
Authors: Volkov Roman L. , Kukin Vladimir N. , Kots Pavel A. , Ivanova Irina I. , Borgardt Nikolay I. 
Published: December 2019

AbstractThe article proposes a new way for visualization of mesopores and quantitative evaluation of the pore structure in zeolite crystals. The approach is based on platinum tracking inside the zeolite material after its incorporation from a gaseous precursor using an electron beam prior to preparing a TEM specimen by the focused ion beam technique. The pores in mesoporous silica and purely microporous zeolite Y were visualized in TEM images in a demonstration of the capabilities of the approach. Finally, platinum tracking was used for studying the pore structure of zeolite Y (CBV 720) containing mesopores both inside the crystal and those emerging at its surface, which were unambiguously distinguished from each other. The obtained sizes of the mesopores and the calculated material porosity are in good agreement with the results obtained by the low‐temperature argon sorption isotherms method.
Endoscopic resection of sinonasal malignancies
Authors: Abdelmeguid Ahmed S. , Raza Shaan M. , Su Shirley Y. , Kupferman Michael , Roberts Dianna , DeMonte Franco , Hanna Ehab Y. 
Published: December 2019

AbstractBackgroundIn this study, we evaluate our experience and the outcomes of patients with sinonasal cancer treated with endoscopic resection.MethodsRetrospective review of patients with sinonasal cancer who had endoscopic resection was conducted. The outcomes of interest included survival outcomes and surgical complications.ResultsOverall, 239 patients were included. Median follow up time was 46.6 months. Of the 239 patients, 167 (70%) had a pure endonasal endoscopic approach, while 72 (30%) had an endoscopic‐assisted approach. Postoperative cerebrospinal fluid (CSF) leakage occurred in 14 patients (5.9%). Negative margins were achieved in 209 patients (87.4%). There was no significant difference in the margin status between the pure endoscopic and endoscopic‐assisted group (P = .682). There was no significant difference in the survival outcomes between both the groups.ConclusionOur data suggest that in properly selected patients, endoscopic approaches have acceptable morbidity with low complication rates and can provide an oncologically sound alterative to open approaches.
Novel synthesis of pyran, thiophene, and pyridine derivatives incorporating thiazole ring and their antitumor evaluation
Authors: Mohareb Rafat M. , Khalil Eid M. , Mayhoub Amany E. , Abdallah Amira E. M. 
Published: December 2019

AbstractThis study aims to design and synthesize a number of novel pyran, thiophene, and pyridine derivatives incorporating thiazole ring and evaluate their antitumor inhibition (μM) as significant anticancer agents. The reactivity of compound 1 [2‐(4‐oxo‐4,5‐dihydrothiazol‐2‐yl)acetonitrile] towards different chemical reagents was described. Furthermore, the reactivity of all the newly synthesized products was evaluated. The most active compounds towards all the three tumor cancer cell lines used such as MCF‐7 (breast adenocarcinoma), NCI‐H460 (non‐small cell lung cancer) and SF‐268 (CNS cancer), and normal fibroblasts human cell line (WI‐38) were compounds 6d, 8, and 10b, which compared with the antiproliferative effects of the reference control doxorubicin. Also, some of the novel compounds indicate higher inhibition than doxorubicin against some of the cancer cell lines used such as 6c (especially towards MCF‐7) and 2b, 6b (especially towards SF‐268).
Physician Barriers and Facilitators for Screening for Congenital Heart Disease With Routine Obstetric Ultrasound
Authors: Pinto Nelangi M. , Henry Kevin A. , Grobman William A. , Ness Amen , Miller Stephen , Ellestad Sarah , Gotteiner Nina , Tacy Theresa , Wei Guo , Minich L. LuAnn , Kinney Anita Y. 
Published: December 2019

ObjectivesPrenatal detection of congenital heart disease with obstetric screening remains at less than 50% in most population studies, far from what is thought to be achievable. We sought to identify barriers/facilitators for screening from the perspective of interpreting physicians and to understand how these barriers/facilitators may be associated with interpretation of screening images.MethodsOur mixed‐methods studies included 4 focus groups in centers across the United States with obstetric, maternal‐fetal medicine, and radiology providers who interpreted obstetric ultrasound studies. Themes around barriers/facilitators for fetal heart screening were coded from transcripts. A national Web‐based survey was then conducted, which quantitatively measured reported barriers/facilitators and measured physicians’ ability to interpret fetal heart‐screening images. Multivariable generalized linear random‐effect models assessed the association between barriers/facilitators and the accuracy of image interpretation at the image level.ResultsThree main themes were identified in the focus groups: intrinsic barriers (ie, comfort with screening), external barriers (ie, lack of feedback), and organizational barriers (ie, study volumes). Among 190 physician respondents, 104 interpreted ultrasound studies. Perceptions of barriers varied by practice setting, with nontertiary providers having lower self‐efficacy and perceived usefulness of cardiac screening. Facilitators associated with the odds of accurate interpretation of screening images were knowledge (odds ratio, 2.54; P = .002) and the volume of scans per week (odds ratio, 1.01 for every additional scan; P = .04).ConclusionsSome of the main barriers to cardiac screening identified and prioritized by physicians across the United States were knowledge of screening and minimal volumes of scans. Targeting these barriers will aid in improving prenatal detection of congenital heart disease.
Electrically small circularly polarized antenna using vialess CRLH‐TL and fractals for L‐band mobile satellite applications
Authors: Ameen Mohammad , Chaudhary Raghvendra Kumar 
Published: December 2019

AbstractThis paper explains the design and development of an electrically small (ka = 0.59) circularly polarized (CP) antenna based on vialess composite right/left‐handed (CRLH) transmission line (TL) and third‐iterative fractals (TIF) applicable for 1.637 GHz L‐band mobile satellite applications. The idea behind the CP antenna originates from the combination of curved meander line inductor on the top side of the substrate back coupled with TIF in backside of the substrate. The loading of TIF provides an increased level of cross polarization by adjusting the dimensions of TIF which is almost equal to the main polarization level of original CRLH‐TL loaded antenna on the top side of the substrate. Due to this, the antenna can generate two orthogonally polarized modes for supporting CP radiation with excellent miniaturization and improved gain. The overall dimensions of the proposed antenna are 22 × 27 × 1.27 mm with radiating element size including the ground plane are 0.11λ0 × 0.14λ0 × 0.006λ0 at 1.635 GHz. The proposed antenna can provide excellent miniaturization of 68.51% compared with the conventional monopole antenna with improved radiation performance. The antenna provides an acceptable impedance bandwidth of 0.73%, improved gain of 1.79 dBi without using complex vias, excellent miniaturization, and low profile (0.006 λ0) compared to existing similar type of antennas in the literature.
Subtle findings on fetal brain imaging in CMV infected pregnancies: What is the clinical significance? A retrospective analysis with outcome correlation
Authors: Roee Birnbaum , Adi Winsteen , Michael Brusilov , Igal Wolman , Karina Krajden Haratz , Liat Ben‐Sira , Gustavo Malinger 
Published: December 2019

AbstractObjectiveTo describe the prognosis of subtle findings on fetal brain imaging in pregnant women with primary CMV infection during pregnancy.MethodsThis was a retrospective study. The data included: timing of infection, amniocentesis results, imaging findings, obstetric outcome, and developmental assessment.ResultsFor the 27 included patients, the time of infection was: periconception, first, second, third trimesters or unknown in 14.8%, 29.7%, 40.7%, 7.4%, and 7.4%, respectively. Seventy‐four percent had only MRI findings; white matter hyperintense T2 signal (HT2) (51.8%), mild ventriculomegaly (18.5%), HT2 and temporal cyst (7.4%), dilated occipital horn (7.4%), Periventricular pseudo cyst (PVPC) with dilated occipital horn (3.7%), isolated PVPC (7.4%), choroid plexus cyst (3.7%). In 26% of fetuses, additional ultrasound findings were observed: Lenticulostriatal vasculopathy (LSV) (11.1%), LSV with PVPC (3.84%), isolated PVPC (3.84%), mild ventriculomegaly (3.84%), and bilateral temporal cysts (3.84%). In 66.6%, the MRI had false‐positive findings (due to noninfected neonates). All children are developing normally, and one has a hearing deficit. Postnatal ultrasound (US) was normal in 21/27, with LSV in five, and a resolving subependymal cyst in one patient.ConclusionSubtle imaging findings are more common on MRI than US and the prognosis is most likely favorable. Performing amniocentesis will significantly reduce the false‐positive rate.
On topological indices of carbon nanocones and nanotori
Authors: Jahanbani Akbar 
Published: December 2019

AbstractLet G be a graph with n vertices and d
i is the degree of its ith vertex (d
i is the degree of v
i). In this article, we compute the redefined first Zagreb index, redefined second Zagreb index, redefined third Zagreb index, augmented Zagreb index of graphs carbon nanocones CNC
k[n], and nanotori [C4C6C8(p,q)]. Also, compute the multiplicative redefined first Zagreb index, multiplicative redefined second Zagreb index, multiplicative redefined third Zagreb index, multiplicative augmented Zagreb index of carbon nanocones CNC
k[n], and nanotori [C4C6C8(p,q)].
Contact surface area and its association with outcomes in robotic‐assisted partial nephrectomy
Authors: Kahn Amanda E. , Shumate Ashley M. , Galler Isabella J. , Ball Colleen T. , Thiel David D. 
Published: December 2019

AbstractBackgroundRenal tumor scoring systems, such as the contact surface area value, aim to assist in predicting outcomes following robotic‐assisted partial nephrectomy. The aim of this study is to identify associations between specific postoperative outcomes and the contact surface area of renal masses.MethodsWe analyzed 332 consecutive robotic‐assisted partial nephrectomies and calculated contact surface area for renal tumors with the contact surface area formula (CSA = 2πrd), where π ≈ 3.14, r = greatest tumor radius (cm), and d = greatest tumor depth (cm).ResultsHigher contact surface area was associated with longer warm ischemia time (P < .001), higher estimated blood loss (P < .001), and longer length of hospital stay (LOS) (P < .001). Higher contact surface area was significantly associated with decreased renal function at 1 day, 1 month, and 6 months following robotic‐assisted partial nephrectomy.ConclusionsContact surface area is associated with certain outcomes following robotic‐assisted partial nephrectomy and may be a useful predictive tool.
A novel surgical navigation technology for placement of implants in slipped capital femoral epiphysis
Authors: Oetgen Matthew E. , Litrenta Jody , Koutenaei Bamshad Azizi , Cleary Kevin R. 
Published: December 2019

AbstractBackgroundFixation with a single screw is the recommended treatment for slipped capital femoral epiphysis (SCFE). Achieving optimal implant positioning can be difficult owing to the complex geometry of the proximal femur in SCFE. We assessed a novel navigation technology incorporating an inertial measurement unit to facilitate implant placement in an SCFE model.MethodsGuidewires were placed into 30 SCFE models, using a navigation system that displayed the surgeon's projected implant trajectory simultaneously in multiple planes. The accuracy and the precision of the system were assessed as was the time to perform the procedure.ResultsImplants were placed an average of 5.3 mm from the femoral head center, with a system precision of 0.94 mm. The actual trajectory of the implant deviated from the planned trajectory by an average of 4.9° ± 2.2°. The total average procedure time was 97 seconds.ConclusionThe use of computer‐based navigation in a SCFE model demonstrated good accuracy and precision in terms of both implant trajectory and placement in the center of the femoral head.
Science notebooks as interactional spaces in a multilingual classroom: Not just ideas on paper
Authors: Wilmes Sara E.D. , Siry Christina 
Published: December 2019

AbstractPast studies have explored the role of student science notebooks in supporting students' developing science understandings. Yet scant research has investigated science notebook use with students who are learning science in a language they are working to master. To explore how student science notebook use is co‐constructed in interaction among students and teachers, this study examined plurilingual students' interactions with open‐ended science notebooks during an inquiry science unit on condensation and evaporation. Grounded in theoretical views of the notebook as a semiotic social space, multimodal interaction analysis facilitated examination of the ways students drew upon the space afforded by the notebook as they constructed explanations of their understandings. Cross‐group comparison of three focal groups led to multiple assertions regarding the use of science notebooks with plurilingual students. First, the notebook supported student‐determined paths of resemiotization as students employed multiple communicative resources to express science understandings. Second, notebooks provided spaces for students to draw upon diverse language resources and as a bridge in time across multiple inquiry sessions. Third, representations in notebooks were leveraged by both students and teachers to access and deepen conceptual conversations. Lastly, students' interactions over time revealed multiple epistemological orientations in students' use of the notebook space. These findings point to the benefits of open‐ended science notebooks use with plurilingual students, and a consideration of the ways they are used in interaction in science instruction.