bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelling and Simulation of Below-the-Hook Lifting Device Balanced C-hook for Load to Investigate the Static and Model Analysis for Various Grades of Steels by Numerical Method
Authors: M R Mahanthesh , L Girisha , Deshpande Malteshkumar , Babu C Shreyas , DC Shivananda 
Published: July 2020

Below-the-Hook Lifting Devices will enable easy loading, unloading and transportation of heavy metal coils. A balanced c-hook is one of the widely used Below-the-Hook Lifting Devices works by inserting its lower arm inside the hole of coil. Multiple variations of c hooks are being used based on different load requirements, and different applications like paper roll c hooks to transport heavy paper rolls, spring loaded c hooks to reduce weight by avoiding counter weights etc. Structural and mechanical lifters may be modified or re-assessed, provided that such alterations are analyzed and approved. Balanced c-Hook are to be designed by considering forces imposed by the lifted load, the weights of the device’s parts, since balanced c hooks are subjected repeated loading and unloading, there is probability of failure due stress concentration. To prevent chances of failure, Prior study is required on this; the materials which are generally used for the C hook are considered for a particular loading condition of 10 Tons, Design of the bellow the hooks is done by numerical method. Modeling and Simulations are carried to determine the various factors like deformation, stresses generated and mode shapes. The comparison among all the selected materials is done to check the suitability of the material to use as a balanced C hook. For the generation of CAD model of C -Hook various geometrical features and Dimensions are selected as per the specification from ASME B30.20 standard. To investigate statics stress results and model are obtained from Finite element Method. from the results of the analysis it is observed that results obtained are in close match with each other and maximum stress concentration occurs at inner most surface.
Modeling of Moisture Crystallization of Bacterial Starter Cultures during Freezing
Authors: Korotkaya Elena , Korotkiy Igor , Vasil'ev Kirill I , Ostroumov L. 
Published: July 2020

Introduction. The quality of fermented milk products directly depends on the bacterial starter cultures involved, which contain lactic acid microorganisms. One of the most effective ways to store bacterial ferments is freezing as it improves the survival rate and preserves the morphological and cultural properties. Changing the phase state of water affects the chemical and biochemical processes during freezing. The present research dealt with the issue of moisture crystallization during freezing of bacterial starter cultures.
Study objects and methods. The study featured bacterial starter cultures of Lactobacillus bulgaricus and Lactobacillus acidophilus. The authors used standard methods to determine their physical and chemical properties; the first buffer method of two temperature and time intervals made it possible to describe the thermal characteristics.
Results and discussion. A set of experiments helped to define the mass fractions of total protein and dry matter, the content of lactic acid, as well as cryoscopic temperatures and thermophysical characteristics of the bacterial cultures in question. The values of the thermophysical characteristics of bacterial ferments proved to depend on the amount of moisture in them. The authors constructed a model of moisture crystallization during freezing of bacterial starter cultures, taking into account the content of lactose and lactic acid. The model made it possible to define the cryoscopic temperatures. Their proved close to the experimental ones. The model of moisture crystallization also provided the freezing time and a method for calculating thermal characteristics and their values. The differences between the calculated and experimental values did not exceed 5.3 %.
Conclusion. The experimental and calculated values of the thermophysical characteristics appeared similar, which means that the proposed model of moisture crystallization during freezing of bacterial ferments proved effective. The model can be used in commercial freezing to calculate thermal characteristics and freezing time.
Plant- and Whey-Based Sustainable Technology: Development Potential
Authors: Maytakov A. , Sarafanov Aleksandr 
Published: July 2020

Introduction. According to the Lighthouse research company, energy consumption in Russian industry exceeds the level of similar enterprises in other countries by 40–220%. In this regard, the urgent task is to find ways to improve the technological level of production in the country. The article features multi-assortment low-tonnage complex food technological in agriculture.
Study objects and methods. Industrial agro-complexes that implement agricultural production technologies, storage, and processing technologies can solve the problem of food security in Russia. The research focused on food technology of open-type system complexes. To design such complexes, one has to pay attention to the entire production chain, from production of raw materials with programmed quality indicators to finished products that meet particular requirements.
Results and discussion. The study summarized various data on the conditions of self-organization of system technological complexes and their main characteristics, e.g. openness, nonlinearity, instability, etc. The article describes the principles that underlie such complexes in agrifood industry, as well as the dialectic character of the synergy of several technologies united into one complex. The authors believe that agricultural industrialization is inevitable as industrial agro-complexes implement a new stage of the innovation revolution in agriculture. Therefore, priorities in agricultural development should be based on forecasts that rely on the current data and take into account the projection horizon.
Conclusion. Research organizations and universities should implement complex technological systems.
Biopharmaceutics and Pharmacokinetics of Timosaponin A-III by a Sensitive HPLC-MS/MS Method: Low Bioavailability Resulting from Poor Permeability and Solubility
Authors: Wang Hai-Qiao , Gong Xiao-Mei , Lan Fen , Zhang Yi-Han , Xia Jin-Er , Zhang Hai , Guo Jia-Lin , Liu Min 
Published: July 2020

Background:
Timosaponin A-III is one of the most promising active saponins from
Anemarrhena asphodeloides Bge. As an oral chemotherapeutic agent, there is an urgent need to clarify
its biopharmaceutics and pharmacokinetics to improve its development potential.

Objective:
This research explores the bioavailability of timosaponin A-III and clarifies its absorption
and metabolism mechanisms by a sensitive and specific HPLC-MS/MS method.

Methods:
Pharmacokinetics and bioavailability studies of timosaponin A-III were performed in Sprague-
Dawley rats by oral (20 mg/kg) and intravenous administration (2 mg/kg). Control group was given
the same volume of normal saline. The absorption of timosaponin A-III was investigated in a rat
intestinal perfusion model in situ and a Caco-2 cell transport model in vitro. The metabolic rate of
timosaponin A-III was determined in a rat liver microsome incubation system.

Results:
After the oral administration, timosaponin A-III reached Cmax of 120.90 ± 24.97 ng/mL at 8 h,
and the t1/2 was 9.94 h. The absolute oral bioavailability of timosaponin A-III was 9.18%. The permeability
coefficients of timosaponin A-III in four intestinal segments ranged from 4.98 to 5.42 × 10-7
cm/s, indicating a difficult absorption. A strikingly high efflux transport of timosaponin A-III was found,
PappBA 3.27 ± 0.64 × 10−6 cm/s, which was abolished by a P-gp inhibitor. Rat liver microsome incubation
studies showed that timosaponin A-III could hardly be metabolized, with a t1/2 of over 12 h. In
addition, the solubility test showed a low solubility in PBS solution, i.e. 30.58 μg/mL.

Conclusion:
Timosaponin A-III exhibited low oral bioavailability by oral and intravenous administration,
which was probably caused by its low permeability and solubility. This study may provide a reference for
its rational clinical use and further study on the pharmacology or toxicology of timosaponin A-III.
Modelos de predicción del impacto y evolución del COVID-19 en República Dominicana
Authors: F. Franco Edian , Calderón Víctor V. , Ramos Rommel T. 
Published: July 2020

Después de su descubrimiento en China, en diciembre de 2019, el virus SARS-CoV-2 causante de la enfermedad COVID-19, comenzó a propagarse por la mayoría de los países del mundo, provocando una cantidad importante de infectados y muertos, situación que ha generado una gran presión en los sistemas de salud y gobiernos de los diferentes países, que en muchos casos no contaban con los recursos e infraestructuras para enfrentar una pandemia provocada por el virus, como fue el caso de República Dominicana. Usando los datos públicos del avance de la pandemia en la Republica Dominicana, desde el 1 de marzo hasta el 30 de abril, se modeló y pronosticó la posible evolución del COVID-19 en este país, utilizando de tres modelos matemáticos SIR, SEIR-Extendido y log-lineal. Estos modelos permitieron proyectar los diferentes escenarios de contagios y evolución de la enfermedad, además de pronosticar el pico y el descenso de la curva de casos. Según los resultados obtenidos, el país se encontraba en un proceso de crecimiento exponencial de los contagios; el pico de los contagios fue pronosticado ocurriría entre la segunda mitad del mes de mayo y la primera mitad del mes de junio, con un estimado de infectados entre 100,000 y 200,000 individuos. Los resultados obtenidos en este estudio permiten obtener una idea de cuál podría ser el impacto humano y social del COVID-19 en la República Dominicana.
Excessive Belching: a Separate Syndrome or Another Symptom of Functional Dyspepsia?
Authors: Sheptulin A. A. , Storonova O. A. 
Published: July 2020

Aim of review. Interpretation of published evidence on the relationship between the excessive belching syndrome and functional dyspepsia (FD) and their management in patient care.Key points. According to the Rome IV criteria of functional gastrointestinal disorders (FGID), excessive belching in the absence of other dyspeptic symptoms is to be considered a manifestation of the excessive belching syndrome, which can be of gastric or supragastric nature. Combination of high-resolution manometry and impedancemetry allows an accurate diagnosis of belching and selection of optimal treatment strategy. Belching complicated by other symptoms of dyspepsia is to be considered yet another FD symptom according to the Rome IV criteria of FGID. Prokinetics are recommended to relieve belching in such cases.Conclusion. Understanding the relationship between the excessive belching syndrome and FD requires further research.
Recommendations of the Russian Gastroenterological Association on Clinical Use of High-Resolution Manometry in Diagnosis of Esophageal Disorders
Authors: Ivashkin V. T. , Mayev I. V. , Trukhmanov A. S. , Storonova O. A. , Abdulkhakov S. A. , Andreev D. N. , Bordin D. S. , Valitova E. R. , Klyaritskaya I. L. , Krivoy V. V. , Kucheryavyi Yu. A. , Lapina T. L. , Morozov S. V. , Sablin O. A. , Semenikhina E. V. , Uspenskiy Yu. P. , Sheptulin A. A. 
Published: July 2020

Aim. Current recommendations of the Russian Gastroenterological Association on clinical use of high-resolution manometry in diagnosis of esophageal disorders are intended to assist in clinical decision making, terminology standardisation and interpretation of clinical data.Key points. In 2018, a joint meeting of the Russian Gastroenterological Association and Russian Neurogastroenterology and Motility Group approved unified terminology and classification of esophageal motor function disorders for high-resolution manometry diagnosis.Gastrointestinal patient complaints typically concern esophageal disorders such as dysphagia, regurgitation, heart-burn, chest pain or belching. To exclude erosive and ulcerative lesions, eosinophilic esophagitis and organic changes, esophagogastroduodenoscopy and biopsy are recommended in pre-treatment. Upon excluding mucosal lesions and esophageal lumen obstruction as causal for symptoms, use of high-resolution manometry is recommended. This method of esophageal examination has become the “gold standard” in diagnosis of motor disorders.High-resolution manometry enables detailed investigation of integral quantitative and qualitative characteristics of esophagus motor function and specific related disorders, analysis of esophageal contractile propagation and strictly coordinated synchronous peristalsis of upper esophageal sphincter, esophagus and lower esophageal sphincter, which malfunction may provoke development of achalasia, esophagospasm, hiatal hernia, ineffective eso pha geal motility and other motor disorders.Conclusion. High-resolution manometry is a relatively new method for study of esophagus motor function gaining increasingly wide application in clinical practice. It enables a medical professional to obtain evidence that may critically affect the choice of optimal patient care strategy and effective treatment. Current recommendations are based on an extensive review of up-to-date information and will be updated with new corpus of clinical data and assessment emerging in evidential medicine to provide gastroenterologists country-wide with latest scientific and practical guidelines.
Lipomatosis intestinal: reporte de dos casos
Authors: Arango Molano Lázaro Antonio , Díaz Claudia Patricia , Londoño Mónica , Ortiz Restrepo Pablo , Cano Méndez Laura María 
Published: July 2020

La lipomatosis intestinal es un término utilizado para describir una proliferación de tejido graso, histológicamente normal, en el tracto gastrointestinal. Se caracteriza por la presencia de tumores benignos, asintomáticos, de crecimiento lento y de origen subepitelial. En raras ocasiones, estos tumores pueden ser sintomáticos y asociarse a complicaciones importantes como obstrucción y sangrado gastrointestinal.
Así, la lipomatosis intestinal es una patología rara, con pocos casos reportados en la literatura y ninguno registrado en Colombia. A continuación, presentamos dos casos evaluados y seguidos en nuestro servicio de Unión de Cirujanos S.A.S de la Universidad de Caldas.
El primero es el caso de un hombre de 70 años con historia de episodios de dolor abdominal tipo cólico, asociados a distensión y diarrea posprandial. La endoscopia digestiva alta inicial reportó múltiples lesiones amarillentas, submucosas, en el duodeno, con diagnóstico histológico de lipomas. En este caso, se realizó una videocápsula endoscópica para determinar la distribución y las características de las lesiones presentes en todo el tracto gastrointestinal, así como para valorar la presencia de complicaciones.
El otro caso es el de un hombre de 81 años, quien ingresó a la institución por lipotimia y sangrado rectal. Por tanto, se realizó una endoscopia alta y una colonoscopia, cuyos resultados fueron normales. Luego de ello, se efectuó una videocápsula endoscópica que mostró lesiones lipomatosas; una de ellas, con sangrado y angiodisplasia al lado. Estas lesiones se manejaron mediante enteroscopia de doble balón y terapia con argón plasma.
Hepatoblastoma del adulto
Authors: Pila-Pérez Rafael , Saurith Monterrosa Jaider Luis , Rosales-Torres Pedro , Pila-Peláez Rafael , Artola-González Javier Alberto 
Published: July 2020

Fundamento: el hepatoblastoma del adulto (HBA) es un tumor hepático poco frecuente y con un mal pronóstico, lo cual contrasta con el hepatoblastoma infantil (HBI). Esta patología aún no ha sido comprendida completamente y hasta la fecha, no se han reportado de forma adecuada más de 50 casos en la literatura médica.
Objetivo: presentar el caso de un paciente que fue egresado de nuestro hospital con el diagnóstico de carcinoma hepatocelular, aproximadamente con 3 meses de anterioridad.
Caso clínico: paciente masculino de 60 años con historia de alcoholismo y de ser un fumador inveterado. Fue ingresado en nuestro hospital por dolor abdominal, en el momento del examen físico, puso de manifiesto un tumor palpable en la región del hipocondrio derecho. Este paciente había sido egresado aproximadamente 3 meses atrás, con el diagnóstico de carcinoma hepatocelular, en el curso de una cirrosis hepática. El hombre falleció por causa de la progresión de la enfermedad y la autopsia reveló la existencia de un HBA.
Conclusiones: el HBA es un tumor infrecuente, de grave pronóstico y muchos casos son asintomáticos hasta el momento del diagnóstico. Dicho tumor, por lo regular, presenta un gran tamaño. Las enzimas hepáticas, la alfafetoproteína y los estudios imagenológicos revelan el diagnóstico de un hepatocarcinoma, el cual es un tumor frecuente en los adultos. Asimismo, el estudio histológico confirma el diagnóstico. Debido a su mal pronóstico, y a las mejores perspectivas de tratamiento en niños, hoy en día es lógico utilizar el tratamiento pediátrico en los adultos. Se necesitan más estudios de investigación para el manejo óptimo del HBA.
Evaluación de la respuesta sostenida en pacientes con dolor crónico de la pared abdominal tratados con infiltración de anestésia local
Authors: Mayorga Ortíz Julian , Otero Regino William , Alzate Granados Juan , Marulanda Fernández Hernando 
Published: July 2020

Introducción: el dolor abdominal crónico es frecuente en consulta externa. El enfoque tradicional es investigar patologías viscerales. El 50 % de esos pacientes finalmente tiene dolor crónico de la pared abdominal (DCPA), generalmente secundario a atrapamiento del nervio cutáneo anterior. Esta entidad se identifica con el signo de Carnett. El tratamiento de elección es infiltrar con lidocaína los puntos dolorosos. Con una postinfiltración hay una mejoría significativa en el 85 %-90 % de los pacientes. Se desconoce la duración de la mejoría postinfiltración. El objetivo de este trabajo es determinar la respuesta sostenida en seguimientos a 1 y 2 años.
Materiales y métodos: estudio de cohorte, retrospectivo, realizado en la unidad de gastroenterología de la Clínica Fundadores. Se incluyeron pacientes adultos mayores de 18 años que hubieran recibido tratamiento con inyección local con lidocaína al 2 % sin epinefrina y que hubieran respondido una encuesta telefónica para evaluar la intensidad del dolor en una escala análoga.
Resultados: se identificaron 360 elegibles y, finalmente, atendieron la entrevista telefónica 324 pacientes (90 %). El 87 % era de sexo femenino. La edad promedio de la población era de 57 años. En la preinfiltración el dolor promedio era 8,7 puntos. En la postinfiltración los pacientes tuvieron una mejoría con una intensidad promedio de 2,38 (p < 0,05). En el 71 % de los pacientes la intensidad del dolor en el seguimiento hasta 2 años tuvo una intensidad promedio de 1,65 (p < 0,05), que representa una mejoría del 81 % en la intensidad (p = 0,001). La fibromialgia tuvo una asociación positiva con la mejoría sostenida del dolor (p = 0,008).
Conclusiones: en los pacientes con DCPA, la infiltración de la pared con anestesia local produce una respuesta sostenida hasta 2 años después del tratamiento.
Teaching children road safety using a simulated environment
Authors: Purcell Catherine 
Published: July 2020

<p>The importance of road safety education is widely acknowledged; however, there is a lack of consistency in road safety interventions currently being used in UK schools. Furthermore, the majority of road safety educational programmes use knowledge-based methods, which do not necessarily translate to improved behaviour in real traffic environments. The use of virtual reality is starting to emerge as a viable option, as it allows for repeated risk-free practice. This study aimed to test the efficacy and playability of a virtual reality road crossing iPad-based game with children aged 7-9 years. A total of 137 children from primary school years 3 and 4 completed the study. The game comprised ten levels increasing in complexity. Participants navigated to a target using a magic portal into the virtual world (the iPad position matching the direction of travel). Remote, anonymous in-game data were collected and the results suggested that performance was significantly better on their final attempt compared to their first attempt, regardless of age of gender. Overall, the results suggest that the iPad-based game allowed the children to practice road crossing in an immersive environment, without risk, and could provide a useful, evidence-based addition to current road safety education in UK schools.</p>
Pengembangan Prosedur Operasional Standar (POS) Room Attendant Pada Mata Kuliah Tata Graha, Program Studi Perhotelan DIII di Universitas Pendidikan Ganesha
Authors: Widiastini Ni Made Ary , Andiani Nyoman Dini 
Published: July 2020

AbstrakPenelitian ini bertujuan untuk mengembangkan prosedur operasional standar yang dapat diterapkan pada mata kuliah Tata Graha pada Program Studi Perhotelan Diploma III, untuk sub mata kuliah room attendant. Tuntutan pekerjaan yang semakin tinggi di hotel, khususnya pada departemen tata graha (housekeeping) menyebabkan lulusan harus memahami standar kerja atau prosedur operasional standar hotel yang selalu mengalami perubahan dari waktu ke waktu demi menciptakan kualitas produk dan layanan hotel. Pada kesempatan ini peneliti melakukan penelitian pada hotel yang berada pada manajemen starwood yang berlokasi di kawasan pariwisata Nusa Dua. Berdasarkan observasi dan wawancara diperoleh dua puluh standar yang dapat diadopsi untuk digunakan sebagai acuan dalam proses belajar mengajar. Adapun prosedur operasional standar untuk petugas kamar (room attendant) yang dimaksud adalah grooming, report to manager, answer telephone, assignments, cleaning supplies caddie, entering guest room, guest in room, room cleaning order, check out room, clean floor, making bed, clean toilet, clean shower wall, amanities, clean furniture, vacuum room, leave room, return cleaning supplies, turn in keys, end of shift. Kata kunci : prosedur operasional standar, housekeeping, room attendant.
PENGARUH KOMPETENSI DAN MOTIVASI KERJA TERHADAP KINERJA KARYAWAN DI PD BPR BANK BULELENG 45
Authors: Dwiyanti Ni Kadek Ayu , Heryanda Komang Krisna , Susila Gede Putu Agus Jana 
Published: July 2020

Abstrak Penelitian ini bertujuan untuk memperoleh temuan eksplanatif yang teruji tentang pengaruh (1) kompetensi dan motivasi kerja terhadap kinerja karyawan, (2) kompetensi terhadap motivasi kerja karyawan, (3) kompetensi terhadap kinerja karyawan, (4) motivasi kerja terhadap kinerja karyawan pada PD. BPR Bank Buleleng 45. Desain penelitian dalam penelitian ini adalah kuantitatif kausal. Subjek dalam penelitian ini adalah seluruh karyawan pada PD BPR Bank Buleleng 45 dan objeknya adalah kompetensi, motivasi kerja, dan kinerja karyawan. Populasi penelitian ini berjumlah 51 karyawan semuanya dijadikan unit pengamatan, sehingga penelitian ini termasuk penelitian populasi. Data dikumpulkan dengan kuesioner, pencatatan dokumen, wawancara langsung dan analisis data menggunakan analisis jalur. Hasil yang diperoleh dalam penelitian ini menunjukkan bahwa (1) Kompetensi dan motivasi kerja berpengaruh positif terhadap kinerja karyawan dengan. (2) Kompetensi berpengaruh positif terhadap motivasi kerja. (3) Kompetensi berpengaruh positif terhadap kinerja karyawan. (4) Motivasi kerja berpengaruh positif terhadap kinerja karyawan karyawan pada PD BPR Bank Buleleng 45. Kata kunci : kinerja, kompetensi, motivasi kerja