bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe infective endocarditis in a patient with hypertrophic obstructive cardiomyopathy: 12 years after combined surgery. A case report
Authors: Lutokhina Yu. A. , Osadchaya V. A. , Morozova N. V. , Chichkova N. V. , Ganieva N. A. , Pigalitsyna M. A. , Dzemeshkevich S. L. 
Published: December 2024

Brief description. A 40-year-old male patient with obstructive hypertrophic cardiomyopathy (HCM) developed episodes of fever up to 39,0° C after carotid endarterectomy. Mitral and aortic valve Enterococcus faecium-induced infective endocarditis was diagnosed. Antibacterial therapy was continued for 3 months. As a result, the infectious and inflammatory process was suppressed, but severe mitral and aortic valve insufficiency required surgical treatment.During the operation, the patient underwent replacement of both affected valves, as well as extended myectomy and cardioverter-defibrillator implantation to prevent sudden cardiac death. Twelve years after surgical treatment of infective endocarditis and HCM, the patient's condition is stable.Discussion. Patients with HCM have an increased risk of infective endocarditis, but with timely diagnosis and active treatment of endocarditis, a good long-term prognosis is possible. In this case, the combined surgery played an extremely important role.
Danon disease in women: a modern view of the problem: a case series
Authors: Myasnikov R. P. , Nefedova D. A. , Kuzina N. N. , Kulikova O. V. , Gagarina E. V. , Mershina E. A. , Drapkina O. M. 
Published: December 2024

Introduction. Danon disease is a rare cardiomyopathy (CMP) with multisystem involvement, which is associated with lysosome-associated membrane protein 2 (LAMP2) gene polymorphisms. This protein is the most important regulator of autophagy and is produced mainly in the myocardium, skeletal muscles and brain. This is reflected in the classic disease triad: hypertrophic CMP, skeletal myopathy and cognitive impairment. Danon disease is characterized by maximum penetrance regardless of sex. Expressivity is much less predictable in women, given the X-linked dominant inheritance and mosaicism of cellular production of the LAMP2 protein as a result of random inactivation of one of the X chromosomes.Brief description. The article presents two clinical cases demonstrating different disease courses in women with Danon disease. The analysis of case records, clinical performance, paraclinical data were carried out.Discussion. In recent years, the widespread development of molecular genetic diagnostics and imaging methods has led to the accumulation of data on natural course and prognosis of Danon disease. It became clear that in female patients with Danon disease, previously considered mainly as mutation carriers, clinical manifestations can vary from low-symptom phenotypes with isolated CMP to severe multisystemic involvement and early onset. Raising awareness among practitioners about the Danon disease specifics in women, multidisciplinary examination, and genetic testing are the basis for timely diagnosis, risk stratification, and treatment initiation.
Familial hypertrophic cardiomyopathy with midventricular obstruction associated with MYH7, FHOD3 and BAG3 gene variants: a case report
Authors: Andreeva S. E. , Marusova M. O. , Bortsova M. A. , Kostareva A. A. 
Published: December 2024

Introduction. Hypertrophic cardiomyopathy (HCM) with midventricular obstruction (MVO) represents a subgroup of increased risk of adverse outcomes. It contributes to development of apical aneurysm, which is an anatomical substrate for the development of malignant arrhythmias, thromboembolism, as well as progression to end stage systolic heart failure. Genetic causes of HCM with MVO are poorly described in Russian and foreign literature.Brief description. We present a case of a 54-year-old female patient with a familial HCM with isolated MVO and rare missense variants in the MYH7, FHOD3 and BAG3 genes. The clinical performance was represented by a paroxysmal atrial fibrillation, as well as episodes of nonsustained ventricular tachycardia.Discussion. According to the European HCM Risk-sudden cardiac death (SCD) calculator, the patient was stratified into an intermediate risk group. However, we also took into account gadolinium-enhanced myocardial areas according to magnetic resonance imaging, as well as no conditions for MVO surgery. This was key in determining the indications for a cardioverter-defibrillator implantation within primary SCD prevention.
ИНСТИТУТ НАСТАВНИЧЕСТВА И ПРОБЛЕМЫ ЕГО РАЗВИТИЯ В СОВРЕМЕННОМ РОССИЙСКОМ ОБЩЕСТВЕ
Authors: Чистяков Анатолий Васильевич , Сусименко Елена Владимировна , Щербакова Лидия Ильинична 
Published: December 2024

Целью исследования выступает анализ специфики функционирования института наставничества и основных проблем его развития в современном российском обществе.
Методологическую базу исследования составляют ключевые положения институционального подхода, предусматривающего рассмотрение наставничества в качестве социального института со свойственными ему функциями, и деятельностного подхода, в рамках которого оно трактуется как определенный вид деятельности, основной целью которой является поддержка комплексного характера, реализуемая в отношении молодых работников, а также создание благоприятных условий для реализации личностного потенциала в трудовой организации.
Результаты исследования. Наставничество выступает в качестве древнейшего способа передачи опыта из поколения в поколение: в различные исторические периоды оно приобретало специфические характеристики и применялось в различных формах, однако в широком смысле наставником всегда считался такой человек, который обладал способностью к трансляции профессиональных и иных знаний и опыта другому лицу или определенной социальной группе. Институт наставничества призван готовить молодое поколение к эффективной реализации трудовой деятельности в условиях постоянно меняющейся социальной реальности, создавать возможности для максимально полного развития молодых работников в рамках выбранных ими профессий, постоянного повышения уровня квалификации и мастерства. Наставничество предполагает сочетание различных видов деятельности, к числу которых относится деятельность диагностического характера, связанная с анализом личностных характеристик наставляемых лиц, выявлением присущих им недостатков, могущих стать препятствиями на пути построения карьеры, реализации творческого и иного потенциала, а также профессионально-обучающая и воспитательная деятельность, предусматривающая передачу молодым работникам набора профессиональных знаний и компетенций, формирование личностных качеств, способствующих эффективному осуществлению трудовой деятельности.
Перспективу исследования составляет последующее изучение основных проблем формирования и перспектив развития института наставничества в современной России, определение новых эффективных форм и средств реализации наставнической деятельности.
Oral clefts - dental development anomaly
Authors: Rastogi Isha 
Published: December 2024

Cleft lip and palate are dental development anomalies. They are common and they should be studied by the clinicians.To study about cleft lip and palate and know about their details in patients so as to treat them well. It is known that clefts occur as dental development anomalies. These need to be diagnosed, examined, treated successfully. When clinicians take this issue as serious, only then the patients will be benefitted.This anomaly is well known to all. Awareness and knowledge both in patients and clinicians is needed. This is a team approach. Also it requires skills on part of the clinician. Investigations, if done timely, can do miracles for this problem.
Age and gender estimation by radiographic evaluation of mandible
Authors: Reddy Rishika , Nagalaxmi Velpula , Zardi Faisal Taiyeballi , Sadathullah Ayesha , Abbagalla Sunayana 
Published: December 2024

The aim of the study was to measure various morphometric parameters of mental foramen, height of ramus, mandibular canal, gonial angle and maxillary sinus in digital panoramic radiographs and to correlate these findings in the determination of Gender and Age. A total of 300 radiographs were reviewed for assessment of age and gender by evaluating mental foramen, mandibular canal, height of ramus, gonial angle and width of maxillary sinus in Digital Panoramic Radiograph. Among all the parameters changes in height of ramus, gonial angle and maxillary sinus was found to be highly significant (p value &#60; 0.05) as age advances. These parameters can be used to predict the age of the individual as there were significant changes in height of ramus, gonial angle and maxillary sinus. For further studies large sample size, and recent modalities in radiology like cone beam computed tomography or Computed tomography scan are required.
Donning of personal protective equipment under direct supervision- A quality improvement study in COVID-ICUs of a tertiary care facility, South India
Authors: Priyadarshi Ketan , Dhandapani Sarumathi , Rajshekar Deepashree , A Benedict Vinothini , Punnen Stessy Ann , Veerappan Kowsalya , Jamir Imola , Sastry Apurba S 
Published: December 2024

: Personal protective equipment has a major role in reducing the transmission of infections to healthcare workers despite the fact that improper doffing techniques can pose a threat of acquiring nosocomial infections. Compliance to donning or doffing is an all or none phenomenon where lack of adherence to sequence or technique can result is transmission of infections. Conducting doffing audit with the help of trained supervisors (dofficers) can significantly improve compliance with doffing guidelines. : This quality improvement study, was conducted at a large-scale tertiary care hospital located in South India, for a one-year period in COVID-ICUs. Doffing audit was conducted by trained dofficers in designated doffing areas for proper technique & sequence of doffing and disposal all through the shifts.: 5834 health care professionals were supervised over 8760 hours with a total doffing compliance of 66.6%. Nurses had better overall and individual component doffing compliance. Biomedical waste segregation compliance was also high among nurses (90.4%). Most common breach is with mask removal.: Nosocomial transmission of infections can be controlled with adherence to proper doffing techniques. Auditing and on spot interventions will help improve the compliance to doffing.
A retrospective observational study on clinical & radiological profile of patients diagnosed with RT PCR confirmed influenza infection admitted in tertiary care centre
Authors: Garg Parul , Singhal Sanjeev , Singhal Sushil Kumar , Agrawal Deeksha , Singhal Shweta 
Published: December 2024

Influenza is a serious respiratory illness that can be debilitating and cause complications leading to hospitalization and death. Hence many patients need ICU management and close diagnostic monitoring in swine flu isolation ward. However fewer studies have been published describing clinical and radiological correlation in confirmed patients with H1N1 influenza admitted. Therefore we have conducted study that describes the clinical and radiographic findings in confirmed H1N1 influenza patients admitted to the intensive care unit (ICU), along with their outcome.To evaluate risk factors, clinical and radiological profile of the confirmed cases of Influenza infection.: In the retrospective observational study 48 patients of influenza, who were diagnosed and treated, will be identified from hospital records at a tertiary care Hospital. All relevant clinical, investigational and treatment data collected from the hospital records. In our study, the maximum percentage of patients was in the age range of 41-60 years with male to female ratio of 1.52:1. All study patients had with fever (100%) while Cough, sputum production, wheezing, and breathlessness were other presenting symptoms. Crepitation was observed as a major sign. Other signs were pedal edema, anemia, cyanosis etc. Comorbid conditions were most commonly diabetes followed by hypertension, CAD and TB. Evaluation of Radiological investigations showed predominantly localization of bilaterally lobes. Consolidation, reticulonodular and nodular patterns were seen on X-ray. Due to illness, mortality was seen in 6(12.5%) patient out of 48patients.In the aftermath of the pandemic, untreated H1N1 influenza an infection that, in a matter of minutes or hours, can cause acute respiratory distress syndrome Meticulous diagnosis based upon clinical signs and symptoms and biochemical and radiological examination with early treatment may further decrease the mortality rate.
Study of histopathological spectrum of lesions of gall bladder with clinico radiological correlation
Authors: Borade Devika Suresh , Kanetkar Sujata R , Patil Nanda J , Jagtap Sunil V 
Published: December 2024

The gallbladder is frequently affected by a spectrum of diseases, ranging from benign inflammatory conditions to aggressive malignancies.Histopathological examination is the cornerstone of diagnosing gallbladder diseases, providing detailed insights into the cellular and tissue-level changes that occur in various conditions. However, the diagnostic process is significantly enhanced when histopathological findings are correlated with clinical and radiological data. Such a multidisciplinary approach not only improves diagnostic accuracy but also improves treatment strategies, leading to better patient outcomes. This study aims to investigate the histopathological spectrum of gallbladder lesions and to establish correlations with clinic-radiological findings, thereby advancing the understanding of gallbladder pathology and its management.To study the histopathological spectrum of lesions of gall bladder with clinic radiological correlationThe most common histopathological diagnosis was chronic non specific cholecystitis with cholelithiasis seen in 48 cases out of 100 cases (48%). Total 70 cases out of 100 (70%) were calculous out of which 65.71% cases were of chronic cholecystitis, 24.28% cases were of acute cholecystitis and 10% cases were of gall bladder carcinoma with n=70. Out of 100 cases, 90% cases had mixed stones, 7.15% cases had cholesterol stones and 2.85% cases had pigment stones.There were 7 cases (7%) of gall bladder carcinoma amongst 100 cases. All 7 cases were of adenocarcinoma of the gall bladder out of which 2 cases showed serosal invasion and infiltration. Multidisciplinary approach is required in the diagnosis and management of gall bladder diseases, integrating clinical, radiological and histopathological findings to ensure accurate diagnosis. Each and every cholecystectomy specimen must be sent for histopathological examination and studied meticulously, as some unusual findings bearing implications on treatment and prognosis may be seen, regardless of the reason for which cholecystectomy is performed.
Dengue virus: Investigate serological and hematological indicators for predictions
Authors: Bhojani Priya Laljibhai 
Published: December 2024

Timely and accurate diagnosis of dengue fever is essential for both efficient treatment and prevention of severe symptoms. Investigating hematological and serological markers for dengue virus infection is the goal of the current investigation. : A laboratory-based cross-sectional study was carried out among patients who visited SVP Hospital in Ahmedabad, Gujarat, between January 2022 and December 2023. Hematological parameters were assessed and blood samples from suspected dengue cases were analyzed using the rapid diagnostic immunochromatography (ICT) approach. Continuous variables were compared between groups infected with dengue and those that were not using the Mann-Whitney U test. A binary logistic regression analysis was performed to evaluate the correlation between dengue positive and other factors. Dengue-positive participants showed low mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC), thrombocytopenia, leucopenia, erythrocytosis, and high hemoconcentration in comparison to dengue-negative people. On the other hand, dengue positivity was significantly predicted by platelet count, total leucocyte count, MCH, MCHC, neutrophil count, and lymphocyte count, according to binary logistic regression. : The features and demographics of dengue-positive cases were determined in this investigation, along with their associations with hematological markers. Moreover, by helping medical professionals diagnose and treat dengue patients faster, the discovered predictive indicators can lessen the disease's effects.
Reproducibility of the Bethesda system for reporting thyroid cytopathology (TBSRTC): An observational study of 100 patients
Authors: Panda Kishori Moni , Naik Reena , Mohiddin Mohd Ghouse 
Published: December 2024

: FNAC is the most commonly used screening test to classify patients with thyroid nodules into six Bethesda categories (category I-VI) and for therapeutic decision making. The 2023 edition of TBSRTC, further simplifies these categories, using single name and describing more clear diagnostic criteria for each of the categories. The aim of this study is to investigate the interobserver reproducibility and usefulness of this classification scheme.: FNAC smears from 100 patients with thyroid nodules from october 2022 to September 2024, over a period of 2 years were analysed retrospectively, which were reviewed and reclassified by two pathologists independently according to 2023 TBSRTC. The interobserver reproducibility was statistically assessed using Cohen’s kappa.: Interobserver agreement was seen in 95 cases (95%) and disagreement was seen in 5 cases (5%). The concordance rate was 100% in the Bethesda I and Bethesda VI, 95% (76 cases) in Bethesda II, 66% (02 cases) in Bethesda III, 66% (08 cases) in Bethesda IV and 66% (02 cases) in Bethesda V. So, interobserver variation was seen among Bethesda II, III, IV and V. Overall Cohen’s kappa value showed excellent agreement. : TBSRTC should be encouraged in our country because it reduces interoberver variability. Although there is excellent interobserver agreement seen in this study, disagreements were seen in the Bethesda categories II, III, IV and V, which corroborated with the findings of the studies done elsewhere.
El padre Joaquín García Sánchez, OSA. Un geógrafo innato
Authors: Bernex Weiss Nicole 
Published: December 2024

Este artículo presenta brevemente al insigne misionero agustino, geógrafo innato, profesor honorario de departamento de Humanidades de la Pontificia Universidad Católica del Perú, el padre Joaquín García Sánchez, OSA. Se relata su extraordinario itinerario geográfico desde su infancia caminando los paisajes de la cuenca minera de Sabero, León, España, hasta su llegada e inmersión en la Amazonía loretana. Constructor de puentes interculturales, el padre Joaquín era hombre de diálogos que se transformaron en obras (Centro de Estudios Teológicos de la Amazonía, Biblioteca Amazónica, Irapay, Shupihui, Kanatari, Monumenta Amazónica, entre otras). Durante más de 55 años se dedicó a vivir en, con y para la Amazonía desde todas sus diversidades biofísicas, socioculturales, económicas, ambientales y políticas. Sus estudios, escucha, generosidad y cercanía con los más relegados; su defensa de la paz y la democracia se conjugaron con el desarrollo de una pastoral indígena y ecoteología. Su impresionante horizonte geográfico integra las dimensiones vivas y vividas de los territorios amazónicos, las memorias y la interescalaridad. Con “Amazonium”, el padre Joaquín nos dejó una herencia científica, moral y alterética excepcional, invitándonos a hacer nuestro este sueño.
Saving Sachamama Through BioTrade: Peru’s Export of Native Biodiversity-Based Products
Authors: Rudbeck Jens , Ivanova Yovita , Maier Sylvia 
Published: December 2024

Two decades ago, the Peruvian government introduced the National BioTrade Promotion Program to support the production and export of agricultural commodities that comply with UNCTAD’s principles and criteria for BioTrade. This article takes stock of some of the program’s achievements over the past 20 years and discusses the challenges that remain to scaling up biodiversity-friendly approaches to agriculture in Peru. We find that the rapid increase in export during the first ten years of the program, which drove the initial optimism about BioTrade’s potential for economic development and biodiversity conservation, has given way to a more cautious assessment as the second decade has seen the expansion of markets for Peruvian biodiversity-based products slow down considerably.
Combination Therapy for Cryptosporidiosis in Immunocompromised Patients: A Systematic Review
Authors: Wiwien Sugih Utami  , M.S. Irham Rozaq  , Laksmi Indreswari  , Cholis Abrori  , Bagus Hermansyah  
Published: December 2024

Cryptosporidium sp. is a pathogen that causes gastroenteritis and may increase mortality and morbidity in immunocompromised patients. Cryptosporidium became widely recognized as a human pathogen. Diarrhea is a common problem in AIDS patients and about 30%–60% of patients in developed countries and 90% in developing countries experience diarrhea. This study was conducted using a systematic review design. Two articles with cohort design and two with case report design were selected based on the eligibility criteria. Three of these studies used a combination of nitazoxanide with azithromycin as an intervention, one in cohort design and two in case report design. One cohort study used a nitazoxanide and fluoroquinolone combination as an intervention. 54 samples participated in this study were post kidney transplantation patients and one sample was with acute lymphoblastic leukemia (ALL). Nitazoxanide and fluoroquinolone combination is a better therapy for cryptosporidiosis in immunocompromised patients compared to nitazoxanide and azithromycin combination. The(OR) for stool clearance was significantly lower with nitazoxanide alone compared to that of nitazoxanide and fluoroquinolone (OR: 0.65, 95% CI: 0.34, 0.92, P= 0.01), and the OR for diarrhea stopped was significantly lower with nitazoxanide alone compared to that of nitazoxanide and fluoroquinolone (OR: 0.45, 95% CI: 0.21, 0.81, P= 0.004). The OR for stool clearance was lower with nitazoxanide and azithromycin than monotherapy (OR 0.27, 95% CI: 0.01, 5.77), but P=0.24, which means not statistically significant.