bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Quantitative Model of Cellular Decision Making in Direct Neuronal Reprogramming
Authors: Merlevede Adriaan , Drugge Viktor , Barker Roger A. , Drouin-Ouellet Janelle , Olariu Victor 
Published: February 2020

AbstractThe direct reprogramming of adult skin fibroblasts to neurons is thought to be controlled by a small set of interacting gene regulators. Here, we investigate how the interaction dynamics between these regulating factors coordinate cellular decision making in direct neuronal reprogramming. We put forward a quantitative model of the governing gene regulatory system, supported by measurements of mRNA expression level dynamics. We find that reinterpreting the interaction between two genes (PTB and nPTB) is necessary to capture quantitative gene interaction dynamics and correctly predict the outcome of various overexpression and knockdown experiments. This analysis is strengthened by a novel analytical technique to dissect system behaviour and reveal the influence of individual factors on resulting gene expression. Overall, we demonstrate that computational analysis is a powerful tool for understanding the mechanisms of direct (neuronal) reprogramming, paving the way for future models that can help improve cell conversion strategies.
Gender diversity influence on board effectiveness and business performance
Authors: Martinez-Jimenez Rocio , Hernández-Ortiz María Jesús , Cabrera Fernández Ana Isabel 
Published: February 2020

PurposeThe purpose of this paper is to analyze the mediating role of board effectiveness (understood as the capacity to efficiently manage and control all functions to guarantee the company’s prosperity) in the relationship between board diversity and firm performance.Design/methodology/approachThe authors use partial least squares methodology to test the direct and indirect relationships between gender diversity in boards of directors and business performance.FindingsAlthough the relationship between the presence of women on the board and the board’s effectiveness is statistically significant, this relationship is negative. However, board effectiveness (measured by the three constructs: strategic control, organizational innovation and decision-making) has a positive and statistically significant effect on business performance. Finally, there is a positive, but not statistically significant, relationship between gender diversity and firm performance.Research limitations/implicationsThe study has a small sample size, and most of the boards of directors analyzed are unequal with only a few companies achieving gender parity.Social implicationsPublic institutions must promote actions to achieve a critical mass of women directors and managers, so that women transcend a merely “symbolic” role on a board and are able to develop their skills and characteristics, thereby improving a board’s effectiveness and business performance.Originality/valueThis paper makes a theoretical contribution to the diversity and governance literature by providing a better understanding of the relationship between board gender diversity and firm performance. It considers the influence of women on the board through a holistic framework, analyzing the mediating role of the board’s effectiveness.
On efficiency and effectiveness of finite volume method for thermal analysis of selective laser melting
Authors: Wang Jin , Wang Yi , Shi Jing 
Published: February 2020

Purpose
Selective laser melting (SLM) is a major additive manufacturing (AM) process in which laser beams are used as the heat source to melt and deposit metals in a layerwise fashion to enable the construction of components of arbitrary complexity. The purpose of this paper is to develop a framework for accurate and fast prediction of the temperature distribution during the SLM process.

Design/methodology/approach
A fast computation tool is proposed for thermal analysis of the SLM process. It is based on the finite volume method (FVM) and the quiet element method to allow the development of customized functionalities at the source level. The results obtained from the proposed FVM approach are compared against those obtained from the finite element method (FEM) using a well-established commercial software, in terms of accuracy and efficiency.

Findings
The results show that for simulating the SLM deposition of a cubic block with 81,000, 189,000 and 297,000 cells, the computation takes about 767, 3,041 and 7,054 min, respectively, with the FEM approach; while 174, 679 and 1,630 min with the FVM code. This represents a speedup of around 4.4x. Meanwhile, the average temperature difference between the two is below 6%, indicating good agreement between them.

Originality/value
The thermal field for the multi-track and multi-layer SLM process is for the first time computed by the FVM approach. This pioneering work on comparing FVM and FEM for SLM applications implies that a fast and simple computing tool for thermal analysis of the SLM process is within the reach, and it delivers comparable accuracy with significantly higher computational efficiency. The research results lay the foundation for a potentially cost-effective tool for investigating the fundamental microstructure evolution, and also optimizing the process parameters in the SLM process.
Typology of value adding FM and CREM interventions
Authors: Jensen Per Anker , Voordt Theo J.M. van der 
Published: February 2020

Purpose
The purpose of this paper is to present an empirical-based typology of facilities management (FM) and corporate real estate management (CREM) interventions that can add value to the core business of organisations and possibly the wider society. The typology is explained, elaborated and discussed with the aim to reach a deeper understanding of value adding management in the context of FM and CREM.

Design/methodology/approach
The paper is based on FM and CREM literature, a survey with 15 expert interviews from six different European countries and cases with examples of interventions from earlier research.

Findings
The typology consists of six types of interventions, some mainly product-related, some mainly process-related and some that can be both. Each type is underpinned by examples from a case company and from interviews.

Research limitations/implications
The number of interviews is limited. The typology with related interventions is not necessarily complete. However, the typology is regarded to include the most important interventions in the current state of practice of FM and CREM.

Practical implications
The typology provides an overview of the different ways FM and CREM can add value. The cases and examples can be used as inspiration for developing specific interventions in practice.

Originality/value
The typology is the first to provide a classification of FM and CREM interventions. By integrating findings from interviews and case studies, this typology contributes to a better understanding and practicing of value adding management.
Do cross-border investors benchmark commercial real estate markets?
Authors: Oertel Cay , Willwersch Jonas , Cajias Marcelo 
Published: February 2020

PurposeThe purpose of this study is to introduce a new perspective on determinants of cross-border investments in commercial real estate, namely, the relative attractiveness of a target market. So far, the literature has analyzed only absolute measures of investment attractiveness as determinants of cross-border investment flows.Design/methodology/approachThe empirical study uses a classic ordinary least squares estimation for a European panel data set containing 28 cities in 18 countries, with quarterly observations from Q1/2008 to Q3/2018. After controlling for empirically proven explanatory covariates, the model is extended by the new relative measurement based on relative yields/cap rates and relative risk premia. Additionally, the study applies a generalized additive mixed model (GAMM) to investigate a potentially nonlinear relationship.FindingsThe study finds on average a ceteris paribus, statistically significant lagged influence of the proxy for relative attractiveness. Nonetheless, a differentiation is needed; relative risk premia are statistically significant, whereas relative yields are not. Moreover, the GAMM confirms a nonlinear relationship for relative risk premia and cross-border transaction volumes.Practical implicationsThe results are of interest for both academia and market participants as a means of explaining cross-border capital flows. The existing knowledge on determinants is expanded by relative market attractiveness, as well as an awareness of nonlinear relationships. Both insights help to comprehend the underlying transaction dynamics in commercial real estate markets.Originality/valueWhereas the existing body of literature focuses on absolute attractiveness to explain cross-border transaction activity, this study introduces relative attractiveness as an explanatory variable.
Collaborative case report: participatory action research into using EQUIP to support community discharge
Authors: Tearle Shaw , S. Sam , Holt Rachel R. 
Published: February 2020

PurposeThere is a need to evaluate an adapted Equipping Youth to help One Another (EQUIP) programme for people with intellectual disabilities and forensic needs. The purpose of this paper is to explore a service user’s experience of completing the intervention as part of their transition into the community.Design/methodology/approachA collaborative case report was used. Following hospital discharge and completion of the adapted EQUIP programme, one service user with mild intellectual disability was supported to share their treatment experiences using participatory action research.FindingsFindings suggest that while the adapted community EQUIP group can support skills acquisition (e.g. problem-solving), discharge processes and community reintegration, professionals need to maintain a person-centred approach mindful of participants’ complex emotional journeys.Research limitations/implicationsThe design allows for tentative conclusions to be made about the service user’s journey and is not necessarily generalisable.Practical implicationsThere is a pressing need to develop the evidence base for interventions offered in the community to people with intellectual disabilities and a history of offending. This report provides some evidence that EQUIP can be adapted to support this population.Originality/valueThis is the first coproduced publication exploring the experience of a service user with intellectual disability who completed an adapted EQUIP programme.
Training needs analysis of nurses caring for individuals an intellectual disability and or autism spectrum disorder in a forensic service
Authors: Burke Dominic , Cocoman Angela 
Published: February 2020

Purpose
Examining the education and training needs of forensic nurses is paramount as services move from the older institutions to new care settings. The purpose of this study was to identify Irish Forensic nurses perceived deficits in their knowledge and skills to assist them to provide effective seamless care for individuals with an intellectual disability within their forensic mental health service, so that appropriate training could be provided.

Design/methodology/approach
Training needs analysis (TNA) procedures are used as a way of establishing the continuing processional development of staff, as they seek to identify the gaps between the knowledge and skills of an individual and the need for further training. A training needs tool developed by Hicks and Hennessy (2011) was used and completed by nurses working in an Irish forensic mental health service. A total of 140 surveys were circulated and 74 were completed (51 per cent response).

Findings
The top priority training needs identified were for additional training in research and audit and in the use of technology. Other self-identified training needs included additional training in behavioural management for challenging behaviour, understanding mental health and intellectual disability and dual diagnosis, training in enhancing communication skills and how to work with patients who have an intellectual disability patients specific training on autistic spectrum disorders and a guide and template for advance individual care planning and for caring for the physical health needs and promoting the physical health needs of these patients.

Originality/value
Despite there being a vast range of training issues identified, the majority of nurses appear to have a clear idea of their training needs to ensure the provision of seamless care for individuals with an intellectual disability within a forensic mental health setting. This TNA has identified the specific needs of nursing staff working at different positions across the interface of intellectual disability and forensic mental health care.
Internal audience strikes back from the outside: emotionally exhausted employees’ negative word-of-mouth as the active brand-oriented deviance
Authors: Lee Sang Bong , Suh Taewon 
Published: February 2020

PurposeReflecting on the importance of negative word-of-mouth (NWOM) executed by internal audience of brand management, this study aims to explore the mechanism of employees’ NWOM in the emotional exhaustion context.Design/methodology/approachFocusing on employees’ active brand-oriented deviances, this study used a surveyed data set (n= 150) collected from negatively aroused employees experiencing a negative event within their organization. Structural equation modeling was adopted to test the hypotheses.FindingsThe current study revealed that employees’ NWOM is associated with emotional exhaustion. Also, it discovered that emotional exhaustion is more strongly associated with employees’ NWOM than turnover intention.Research limitations/implicationsRelying on self-regulation theory, the current study identified emotional exhaustion as a critical antecedent of employees’ NWOM. Future researchers can use the longitudinal research design or temporal separation as an effort to prevent common method variance.Practical implicationsInternal audiences engage in negative brand-oriented performance by spreading NWOM. Further, the advance in social media may instigate NWOM spread by internal audiences to external audiences.Originality/valueThis paper tests the explanatory power of conservation of resources theory and self-regulatory theory in terms of the impact of employees’ emotional exhaustion on NWOM and turnover intention.
Analyzing different types of negative online consumer reviews
Authors: Lis Bettina , Fischer Maximilian 
Published: February 2020

Purpose
This study aims to investigate if different types of negative electronic word-of-mouth (eWOM) have various negative effects on the attitude of the consumer toward a product (Laptop) and whether this newfound attitude remains unaffected by the subsequent influence of positive eWOM.

Design/methodology/approach
A quantitative study in Germany was conducted. In the two-part experimental setting, first, a factorial repeated-measures between-subjects design was used in which the types of negative eWOM have been manipulated. The second part is characterized by a mixed between–within subjects design to test the durability of attitudinal changes.

Findings
The results demonstrate that destructive and ethical eWOM only provoke a small decline in consumer attitude compared to functional product criticism. Furthermore, the examination shows that renewed positive eWOM can improve the attitude, whereas ethical criticism is the most difficult to correct.

Research limitations/implications
The study views negative eWOM differentiated. Researchers could adopt this approach by analyzing online communication more precisely. Ambivalent relationships between negative eWOM and their outcomes can be explained.

Practical implications
The findings lessen the fear of permanent loss of brand reputation caused by negative reviews. The harmful effects on the attitude can be compensated through targeted marketing management actions. The study shows which content companies need to focus on.

Originality/value
Previous literature has predominantly overlooked the complex nature of negative eWOM. Therefore, the study provides first empirical results about the divergent effect of different content types of negative eWOM on consumer attitude toward a product. Additionally, the durability of consumer negativity could be measured over time.
Multidimensional management framework for creative places
Authors: Mengi Onur , Guaralda Mirko 
Published: February 2020

Purpose
The purpose of this paper is to explore the creative city discourse expanding on current tangible and intangible strategies, by integrating recent placemaking tactics to develop a multidimensional framework for designing creative places.

Design/methodology/approach
The methodology is based on a framework analysis and critical meta-review of current research on creative city and placemaking.

Findings
The findings show that there are three additional factors related to placemaking tactics in the established literature: institutional factors, human factor and arts and design factor emerging from the intersection of creative city and placemaking frameworks.

Practical implications
The findings of this study can inform a more holistic approach to placemaking in creative cities in both theory and practice, namely, a multidimensional place management framework for creative environments of today.

Originality/value
This paper contributes to the current trends in creative city and the development of placemaking guidelines. It provides a simplified view of an exhaustive list of existing literature.
The effect of entrepreneurial orientation variables on business performance in the SME industry context
Authors: Wahyuni Ni Made , Sara I Made 
Published: February 2020

PurposeThe purpose of this study is to provide new practical and theoretical insights into how small and medium-sized enterprises (SMEs) adjust and further develop business competencies, innovations and performance by using market orientation, learning orientation behaviors and entrepreneurial orientation.Design/methodology/approachThe data was collected from manufacturing SMEs of textile products that had a number of employees between 5 and 99 people in the province of Bali, Indonesia, in 2016. Bali province was chosen as a research location because Bali was one of the tourism centers in Indonesia and even in the world was considered suitable for this research. It was because it had textile product industries that contributed in the fulfillment of the needs of tourism clothing, national economy, the fulfillment of fashion needs and foreign exchange contributors from non-oil exports (Industry and Trade Service of Bali).FindingsBased on the results of descriptive and inferential analysis that has been conducted, it can be concluded that the answer to the problems and objectives that have been determined is market orientation, learning orientation and entrepreneurial orientation affect business performance through knowledge competence and innovation directly and its influence is significantly positive. But market orientation, learning orientation and entrepreneurial orientation do not directly have a significant positive effect on innovation through knowledge competence. Market orientation, learning orientation and entrepreneurship orientation indirectly have a significant positive effect on business performance through knowledge and innovation competencies.Originality/valueThe lack of studies in the existing literature underscores the potential contribution of this subsequent study. The novelty of the research is first to develop a concept of learning orientation that is linked to competence of knowledge, which this link has not been much expressed in the context of industry SMEs; second, to build the concept of innovation development of small and medium-sized industry of textile industry based on market orientation by strengthening the mediation role of competence of knowledge.
A hybrid method for forecasting new product sales based on fuzzy clustering and deep learning
Authors: Yin Peng , Dou Guowei , Lin Xudong , Liu Liangliang 
Published: February 2020

Purpose
The purpose of this paper is to solve the problem of low accuracy in new product demand forecasting caused by the absence of historical data and inadequate consideration of influencing factors.

Design/methodology/approach
A hybrid new product demand forecasting model combining clustering analysis and deep learning is proposed. Based on the product similarity measurement, the weight of product similarity attributes is realized by using the method of fuzzy clustering-rough set, which provides a basis for the acquisition and collation of historical sales data of similar products and the determination of product similarity. Then the prediction error of Bass model is adjusted based on similarity through a long short-term memory neural network model, where the influencing factors such as product differentiation, seasonality and sales time on demand forecasting are embedded. An empirical example is given to verify the validity and feasibility of the model.

Findings
The results emphasize the importance of considering short-term impacts when forecasting new product demand. The authors show that useful information can be mined from similar products in demand forecasting, where the seasonality, product selling cycles and sales dependencies have significant impacts on the new product demand. In addition, they find that even in the peak season of demand, if the selling period has nearly passed the growth cycle, the Bass model may overestimate the product demand, which may mislead the operational decisions if it is ignored.

Originality/value
This study is valuable for showing that with the incorporation of the evaluation method on product similarity, the forecasting model proposed in this paper achieves a higher accuracy in forecasting new product sales.
Leadership for integrated care: a case study
Authors: Kozlowska Olga , Seda Gombau Gemma , Rea Rustam 
Published: February 2020

Purpose
Integration of health services involves multiple interdependent leaders acting at several levels of their organisation and across organisations. This paper aims to explore the complexities of leadership in an integrated care project and aims to understand what leadership arrangements are needed to enable service transformation.

Design/methodology/approach
This case study analysed system and organisational leadership in a project aiming to integrate primary and specialist care. To explore the former, the national policy documents and guidelines were reviewed. To explore the latter, the official documents from the transformation team meetings and interview data from 17 health-care professionals and commissioners were analysed using thematic analysis with the coding framework derived from the comprehensive and multilevel framework for change (Ferlie and Shortell, 2001).

Findings
Although integration was supported in the narratives of the system and organisational leaders, there were multiple challenges: insufficient support by the system level leadership for the local leadership, insufficient organisational support for (clinical) leadership within the transformation team and insufficient leadership within the transformation team because of disruptions caused by personnel changes, roles ambiguity, conflicting priorities and insufficient resources.

Practical implications
This study provides insights into the interdependencies of leadership across multiple levels and proposes steps to maximise the success of complex transformational projects.

Originality/value
This study’s practical findings are useful for those involved in the bottom-up integrated projects, especially the transformation teams’ members. The case study highlights the need for a toolkit enabling local leaders to operate effectively within the system and organisational leadership contexts.