bluuebunny/crossref_metadata_2025_split huggingface dataset:
HER2 status testing by immunohistochemical and fFluorescence in situ hybridization in China
Authors: Tao W. , Zefei J. , Xuan Z. , Xiaobing L. , Shaohua Z. , Ge S. , Min Z. , Shikai W. , Santai S. 
Published: August 2020

e22233 Background: HER2 gene overexpression is associated with aggressive breast cancer and poor clinical prognosis. Humanized anti-HER2 monoclonal antibody trastuzumab, which is targeted HER2 protein has showed to improve overall survival in patients with HER2-positive breast cancer in both the metastatic and adjuvant settings. There are some differences in HER2 positive rate among difference reports in China. This study tested HER2 status by immunohistochemistry(IHC) and fluorescence in situ hybridization (FISH) and compared HER2 testing at central and regional laboratories in China. Methods: Assessment of HER2 status was performed by FISH using the HercepTeast kit at central laboratory and by IHC using commercial available anti-HER2 probe in formalin-fixed and paraffin-embedded tissue section of 280 breast cancer samples. IHC HER2 testing was performed on 149 samples in the central laboratory. IHC HER2 testing was performed on 80 samples at both central laboratory and regional laboratory. Results: 280 samples were tested 373 times testing by IHC and FISH. The results were showed in table 1 . 80 samples was tested by IHC at central and regional laboratory and testing results of 36.4% samples were accordant (K=0.038). 94.1% IHC3+ at central laboratory were HER2 FISH positive and 83.3% IHC 3+ at regional laboratory were HER2 FISH positive. 86.7% IHC 2+ at central laboratory were HER2 FISH positive and 62.7% IHC 2+ at regional laboratory were HER2 FISH positive. 17 samples were observed HER2 FISH positive in the 27 IHC 0/1+ tested at regional laboratoty. So good correlation was obsearved between FISH HER2 status and IHC results from central laboratory but not from regional laboratory. Conclusions: This study emphasized the important of accurate HER2 testing. HER2 FISH test should be performed for the IHC 2+ samples. Even HER2 FISH test maybe performed for IHC 0/1 sample according to clinical characteristics in China in order to make the patients have targeted therapy chance. [Table: see text] No significant financial relationships to disclose.
Efficacy results from the ToGA trial: A phase III study of trastuzumab added to standard chemotherapy (CT) in first-line human epidermal growth factor receptor 2 (HER2)-positive advanced gastric cancer (GC)
Authors: Van Cutsem E. , Kang Y. , Chung H. , Sawaki A. , Lordick F. , Hill J. , Lehle M. , Feyereislova A. , Bang Y. 
Published: August 2020

LBA4509 The full, final text of this abstract will be available in Part II of the 2009 ASCO Annual Meeting Proceedings, distributed onsite at the Meeting on May 30, 2009, and as a supplement to the June 20, 2009, issue of the Journal of Clinical Oncology. [Table: see text]
Breast cancer molecular profiles and tumor response of neoadjuvant doxorubicin and paclitaxel: The I-SPY TRIAL (CALGB 150007/150012, ACRIN 6657)
Authors: Esserman L. J. , Perou C. , Cheang M. , DeMichele A. , Carey L. , van 't Veer L. J. , Gray J. , Petricoin E. , Conway K. , Berry D. 
Published: August 2020

LBA515 The full, final text of this abstract will be available in Part II of the 2009 ASCO Annual Meeting Proceedings, distributed onsite at the Meeting on May 30, 2009, and as a supplement to the June 20, 2009, issue of the Journal of Clinical Oncology. [Table: see text]
A randomized, phase III study of carboplatin and pegylated liposomal doxorubicin versus carboplatin and paclitaxel in relapsed platinum-sensitive ovarian cancer (OC): CALYPSO study of the Gynecologic Cancer Intergroup (GCIG)
Authors: Pujade-Lauraine E. , Mahner S. , Kaern J. , Gebski V. , Heywood M. , Vasey P. , Reinthaller A. , Vergote I. , Pignata S. , Ferrero A. 
Published: August 2020

LBA5509 The full, final text of this abstract will be available in Part II of the 2009 ASCO Annual Meeting Proceedings, distributed onsite at the Meeting on May 30, 2009, and as a supplement to the June 20, 2009, issue of the Journal of Clinical Oncology. No significant financial relationships to disclose.
A randomized, phase III study (AGO-OVAR-9, GINECO-TCG, NSGO-OC-0102): Gemcitabine-paclitaxel-carboplatin versus paclitaxel-carboplatin as first-line treatment of ovarian cancer (OC): Survival of FIGO stage I-IIA patients
Authors: Herrstedt J. , Huober J. , Priou F. , Müller H. , Baekelandt M. , Kurzeder C. , Pfisterer J. , Stähle A. , Ray-Coquard I. , du Bois A. 
Published: August 2020

LBA5510 The full, final text of this abstract will be available in Part II of the 2009 ASCO Annual Meeting Proceedings, distributed onsite at the Meeting on May 30, 2009, and as a supplement to the June 20, 2009, issue of the Journal of Clinical Oncology. [Table: see text]
Longitudinal Changes in Hematologic Parameters Among Transgender People Receiving Hormone Therapy
Authors: Antun Ana , Zhang Qi , Bhasin Shalender , Bradlyn Andrew , Flanders W Dana , Getahun Darios , Lash Timothy L , Nash Rebecca , Roblin Douglas , Silverberg Michael J , Tangpricha Vin , Vupputuri Suma , Goodman Michael 
Published: August 2020

Abstract

Context
The effect of gender-affirming hormone therapy (HT) on erythropoiesis is an area of priority in transgender health research.

Objective
To compare changes in hematologic parameters and rates of erythrocytosis and anemia among transgender people to those of cisgender controls.

Design
Longitudinal observational study.

Participants and Setting
We compared 559 transfeminine (TF) and 424 transmasculine (TM) people enrolled in 3 integrated health care systems to matched cisgender referents.

Interventions and Outcome
Hormone therapy receipt was ascertained from filled prescriptions. Hemoglobin (Hb) and hematocrit (Hct) levels were examined from the first blood test to HT initiation, and from the start of HT to the most recent blood test. Rates of erythrocytosis and anemia in transgender participants and referents were compared by calculating adjusted hazard ratios and 95% confidence intervals (CI).

Results
In the TF group, there was a downward trend for both Hb and Hct. The corresponding changes in the TM cohort were in the opposite direction. TM study participants experienced a 7-fold higher rate (95% CI: 4.1–13.4) of erythrocytosis relative to matched cisgender males, and an 83-fold higher rate (95% CI: 36.1–191.2) compared to cisgender females. The corresponding rates for anemia were elevated in TF subjects but primarily relative to cisgender males (hazard ratio 5.9; 95% CI: 4.6–7.5).

Conclusions
Our results support previous recommendations that hematological parameters of transgender people receiving HT should be interpreted based on their affirmed gender, rather than their sex documented at birth. The clinical significance of erythrocytosis following testosterone therapy, as well as anemia following feminizing HT, requires further investigation.
Metabolomic Profiling After a Meal Shows Greater Changes and Lower Metabolic Flexibility in Cardiometabolic Diseases
Authors: Yu Elaine A , Yu Tianwei , Jones Dean P , Ramirez-Zea Manuel , Stein Aryeh D 
Published: August 2020

Abstract

Context
Metabolic flexibility is the physiologic acclimatization to differing energy availability and requirement states. Effectively maintaining metabolic flexibility remains challenging, particularly since metabolic dysregulations in meal consumption during cardiometabolic disease (CMD) pathophysiology are incompletely understood.

Objective
We compared metabolic flexibility following consumption of a standardized meal challenge among adults with or without CMDs.

Design, Setting, and Participants
Study participants (n = 349; age 37-54 years, 55% female) received a standardized meal challenge (520 kcal, 67.4 g carbohydrates, 24.3 g fat, 8.0 g protein; 259 mL). Blood samples were collected at baseline and 2 hours postchallenge. Plasma samples were assayed by high-resolution, nontargeted metabolomics with dual-column liquid chromatography and ultrahigh-resolution mass spectrometry. Metabolome-wide associations between features and meal challenge timepoint were assessed in multivariable linear regression models.

Results
Sixty-five percent of participants had ≥1 of 4 CMDs: 33% were obese, 6% had diabetes, 39% had hypertension, and 50% had metabolic syndrome. Log2-normalized ratios of feature peak areas (postprandial:fasting) clustered separately among participants with versus without any CMDs. Among participants with CMDs, the meal challenge altered 1756 feature peak areas (1063 reversed-phase [C18], 693 hydrophilic interaction liquid chromatography [HILIC]; all q &lt; 0.05). In individuals without CMDs, the meal challenge changed 1383 feature peak areas (875 C18; 508 HILIC; all q &lt; 0.05). There were 108 features (60 C18; 48 HILIC) that differed by the meal challenge and CMD status, including dipeptides, carnitines, glycerophospholipids, and a bile acid metabolite (all P &lt; 0.05).

Conclusions
Among adults with CMDs, more metabolomic features differed after a meal challenge, which reflected lower metabolic flexibility relative to individuals without CMDs.
Worlds of Journalism: Journalistic Cultures Around the Globe, Thomas Hanitzsch, Folker Hanusch, Jyotika Ramaprasad and Arnold S. de Beer (eds) (2019)
Authors: Bebawi Saba 
Published: August 2020

Review of: Worlds of Journalism: Journalistic Cultures Around the Globe, Thomas Hanitzsch, Folker Hanusch, Jyotika Ramaprasad and Arnold S. de Beer (eds) (2019)
New York: Columbia University Press, 448 pp.,
ISBN 978-0-23118-643-8, p/bk, $35.00,
ISBN 978-0-23118-642-1, h/bk, $105.00,
ISBN 978-0-23154-663-8, e/bk, $34.99
The Future Foreign Correspondent, Saba Bebawi and Mark Evans (2019)
Authors: Greste Peter 
Published: August 2020

Review of: The Future Foreign Correspondent, Saba Bebawi and Mark Evans (2019)
Sydney: Palgrave Macmillan, 120 pp.,
ISBN 978-3-03001-667-8, h/bk, €49.99,
ISBN 978-3-03001-668-5, e/bk, €42.79
The coral aquarium: A review of Coral Empire by Ann Elias
Authors: Han Lisa Yin 
Published: August 2020

Review of: The coral aquarium: A review of Coral Empire by Ann Elias

Coral Empire: Underwater Oceans, Colonial Tropics, Visual Modernity, Ann Elias (2019)
Durham, NC: Duke University Press, 296 pp.,
ISBN 978-1-47800-382-3, p/bk, $26.95
HUBUNGAN AGAMA DAN NEGARA MENURUT PANCASILA DAN UNDANG-UNDANG DASAR NEGARA REPUBLIK INDONESIA TAHUN 1945
Authors: Shaleh Ali Ismail , Wisnaeni Fifiana 
Published: August 2020

Tulisan ini membahas tentang hubungan agama dan Negara menurut Pancasila dan Undang Undang Dasar 1945. Hubungan antara agama dan Negara senantiasa menghadirkan sebuah konsekuensi hukum di Indonesia yang berlandaskan ketuhanan yang maha esa, menegaskan bahwa Negara atas nama Konstitusi mengurusi urusan agama dan kepercayaan, sehingga menghadirkan pluralisme hukum di dalam menjalani politik hukum yang harmonis. Negara secara aktif dan dinamis harus menyokong setiap individu-individu sehingga terciptanya kerukunan umat beragama dan tercapai lah hubungan ideal yang di harapkan oleh pendiri Negara.
Penegakan Hukum Keimigrasian Terhadap Penyalahgunaan Visa Izin Tinggal Kunjungan Lewat Batas Waktu (Overstay) Pada Warga Negara Asing
Authors: Muhlisa Aisyah Nurannisa , Roisah Kholis 
Published: August 2020

Imigrasi merupakan instansi yang berwenang menyelenggarakan pengawasan lalu lintas orang masuk dan keluar dari wilayah Indonesia. Pemerintah Indonesia berupaya mendukung pertumbuhan ekonomi melalui sektor pariwisata guna meningkatkan sumber devisa. Sehingga pemerintah memberikan bebas visa kunjungan singkat kepada warga negara asing. Visa merupakan izin (persetujuan) untuk masuk, berwujud cap dan paraf yang dibubuhkan oleh pejabat perwakilan bersangkutan pada paspor pemohon. Orang asing yang masuk ke Indonesia memanfaatkan kemudahan bebas visa kunjungan dengan melakukan pelanggaran keimigrasian seperti penyalahgunaan batas waktu izin tinggal untuk melaksanakan kegiatan-kegiatan yang tidak sesuai aturan hukum keimigrasian. Penelitian ini bertujuan mengkaji penegakan hukum oleh keimigrasian kepada orang asing yang melakukan penyalahgunaan visa kunjungan lewat batas waktu. Hasil penelitian ini melihat bagaimana penegakan hukum keimigrasian bertindak sesuai Undang-Undang Nomor 6 Tahun 2011 tentang Keimigrasian dan Peraturan Presiden Nomor 21 Tahun 2016 tentang Bebas Visa Kunjungan, dengan cara pengawasan kelengkapan prosedur administratif izin tinggal kunjungan orang asing, dan menindak secara administratif kepada yang melanggar izin tinggal dengan mengenakan kepada orang asing membayar biaya beban, dan pemulangan kenegara asal.
Themata in science and in common sense
Authors: Marková Ivana 
Published: August 2020

Abstract
Human thinking is heterogeneous, and among its different forms, thinking in dyadic oppositions is associated with the concept of themata. Gerald Holton characterises themata as elements that lie beneath the structure and development of physical theories as well as of non-scientific thinking. Themata have different uses, such as a thematic concept, or a thematic component of the concept; a methodological (or epistemological) thema; and a propositional thema. Serge Moscovici has placed the concept of themata in the heart of his theory of social representations which is based on ‘natural thinking’ and on forms of daily knowing, including common sense. In this article I shall explore some features of thematic concepts and of methodological themata in scientific theories and in common sense. More specifically, I shall refer to the significance of the methodological (or epistemological) thema the Self and Other(s) in common-sense thinking and in social practices.
Factors Influencing Uber Adoption In Bangladesh And Pakistan
Authors: Rahman Ummeh Habiba Faria Benteh , Zafar Muhammad Khubaib 
Published: August 2020

AbstractThe paper’s intention is to investigate the behavioral intentions of consumers towards the adoption of Uber with focus on effects of digitalization and shared economy on the adoption of Uber. The aim of the article is to examine the cultural factors of Bangladesh and Pakistan, which are leading people towards adopotion of non traditional source of transport. Particularly, these countries’ comparison was not done before by other researchers. Theory of Planned Behavior integrated with Hofstede’s Cultural Dimensions has been used to examine the Behavioral Intention of customers of these two countries towards adoption of Uber in the research. A great comparison was done in the study by using factors of TAM, TPB and Hofstede Cultural Models. Dependent variables played important roles in showing positive and negative attitudes on independent variables. This article’s findings show that “Risk” negatively affects the Behavioral Intention. Research data is collected through online close-ended questionnaires from 145 total respondents, which limits the generalization of the study. At the end, where it identified “female” as a bigger market and provided an opportunity for Uber to categorize the risks prevalent in the society and define new strategies by adapting to the local culture by being a global company. Factors examination produced a great findings which created recommendations for future researchers followed by a conclusion.
Intuición trans-demoníaca
Authors: Otálora Luna Fernando 
Published: August 2020

La intuición no es tratada por la etología, lo cual la excluye de los animales no humanos, sin embargo, psicólogos, neurólogos y filósofos reconocen que la intuición, del latín intueri «mirar hacia dentro», es percibir y decidir instantáneamente, sin la participación de la razón, y con la intervención de la parte más primitiva del sistema nervioso central de los animales humanos. La fenomenología apela a la experiencia intuitiva como fundamento del estudio de la realidad, manifiesta al ser (intuitivo), tal como es. La intuición se asocia con experiencias previas, y de acuerdo al controversial misticismo cuántico: incluso con el futuro. Pero no se puede explicar con claridad racional, sino con expresiones emotivas, de por qué, luego de procesar tal información, se llega a tal conclusión, decisión o creación (œuvre d'art). La intuición es un fenómeno de animales humanos, y de animales no humanos, y más que eso. Es un fenómeno de las cosas vivas. Propongo, obviamente por intuición, su reconocimiento en un dialogo de saberes donde se ejercite más ésta y menos la razón.
Lectura musical vicaria. Lectura, comunidades interpretativas y discurso sonoro: el caso del Hei mihi Domine de Francisco Guerrero y su lectura en La Catedral de Bogotá
Authors: Fonseca Miguel 
Published: August 2020

El objetivo fundamental del presente artículo consiste en vincular el concepto de comunidades interpretativas a una posible hermenéutica de la música. De este modo, el lenguaje musical podría ser interpreteado más fácilmente, si se describe analogicamente con su raiz lingüística. De ello deviene que una descripción de las prácticas y comunidades intepretativas de la música, estaría ampliamente emparentada con las prácticas y comunidades interpretativas de los lenguajes naturales. Esta tentación metodológica quiere razonar a través de un caso. Se pretende ver la plausibilidad de la hipótesis con un experimento. El experimento consiste en mostrar cómo se leyó la música de Francisco Guerrero en la Bogotá de la colonia, y señalar si en este caso existen relaciones con el desarrollo de la lectura de lenguajes naturales o, si por el contrario, hay discontinuidades. Se quiere ver si el concepto de comunidades interpretativas puede dar cuenta en cierta medida de la dialéctica entre obra musical y el sentido extratextual del lenguaje musical. Se intentará mostrar así que quizá la música no sea solamente un lenguaje sintáctico, sino que su semántica puede devenir de lo extramusical que se cuela en las prácticas de quien la escribe y quien la lee.
Clinical Prediction Rule for Distinguishing Bacterial From Aseptic Meningitis
Authors: Mintegi Santiago , García Silvia , Martín María José , Durán Isabel , Arana-Arri Eunate , Fernandez Catarina Livana , Benito Javier , Hernández-Bou Susanna ,   Meningitis Group of the Spanish Society of Pediatric Emergencies
Published: August 2020

BACKGROUND:
New biomarkers like procalcitonin and C-reactive protein may help design an accurate decision support tool used to identify children with pleocytosis at low or high risk of bacterial meningitis. Our objective was to develop and validate a score (that we call the meningitis score for emergencies [MSE]) to distinguish bacterial meningitis from aseptic meningitis in children with pleocytosis when initially evaluated at the emergency department.

METHODS:
We included children between 29 days and 14 years old with meningitis admitted to 25 Spanish emergency departments. A retrospective cohort from between 2011 and 2016 was used as the derivation set and a prospective cohort recruited during 2017 and 2018 was used as the validation set.

RESULTS:
Among the 1009 patients included, there were 917 cases of aseptic meningitis and 92 of bacterial meningitis. Using multivariable logistic regression analysis, we identified the following predictors of bacterial meningitis from the derivation set: procalcitonin &gt;1.2 ng/mL, cerebrospinal fluid (CSF) protein &gt;80 mg/dL, CSF absolute neutrophil count &gt;1000 cells per mm3, and C-reactive protein &gt;40 mg/L. Using the derivation set, we developed the MSE, assigning 3 points for procalcitonin, 2 points for CSF protein, and 1 point for each of the other variables. An MSE ≥1 predicted bacterial meningitis with a sensitivity of 100% (95% confidence interval [CI]: 95.0%–100%), a specificity of 83.2 (95% CI: 80.6–85.5), and a negative predictive value of 100% (95% CI 99.4–100.)

CONCLUSIONS:
The MSE accurately distinguishes bacterial from aseptic meningitis in children with CSF pleocytosis.
Megameatus intact prepuce and associated anomalies
Authors: EKBERLİ Günay , ATEŞ Ufuk , SÖZDUYAR Sümeyye , GURBANOV Anar , GÖLLÜ Gülnur , KOLOĞLU Meltem , YAĞMURLU Aydın , DİNDAR Hüseyin , ÇAKMAK Ahmet 
Published: August 2020

Objective: Megameatus intact prepuce is described as subset of megalourethra or distal hypospadias by several authors. Despite suggested different operative techniques, some authors prefer not to operate this variant of penile anomaly. We aimed to evaluate 31 patients operated due to megameatus intact prepuce and associated anomalies .
Material and methods: Thirtyone patients operated between 2008-2018 for MIP were evaluated retrospectively. All data were collected from hospital records. Patient age, application reasons, raphe anomalies, associated genitourinary and extragenitourinary pathologies, operative techniques, and postoperative complications were analyzed.
Results: Mean age was 50 months (8-128 months). Ten of the patients had raphe anomalies. Genital raphe hyperpigmentation was seen in 1 patient, raphe deviation and bifurcated raphe was seen in6 and 3 patients respectively. Genitourinary anomalies were detected in 7 patients, bilateral undescended testes in 1 patient, penile chordee in 2 patients, ureteropelvic junction obstruction in 2 patients, penoscrotal web in 1 patient, nocturnal enuresis in one patient. Tubularized incised plate urethroplasty (TIPU) (n=5), tubularized urethral plate urethroplasty (TUPU)(n=16) and meatoplasty (n=10) were the operative techniques.
Conclusion: . Co-occuring raphe anomalies should arise awareness of MIP among the clinicians who are engaged with the children’s medical conditions and also the possible anomalies especially in the societies which circumcision is not traditionally required. Further studies with large number series needed for better understanding of this pathology.
Relative Locations of an Earthquake Sequence Recorded during June 2017 on the Koyna–Warna Borehole Seismic Network of Western India
Authors: Shashidhar Dodla , Rodriguez Ismael Vera , Mallika Kothamasu , Kühn Daniela , Wilks Matthew , Satyanarayana Hari Venkata Subramanya , Oye Volker 
Published: August 2020

ABSTRACTIn the Koyna–Warna region, western India, an enormous number of microearthquakes was detected automatically on borehole records. Most of these events could not be identified on the surface network by a routine approach based on visual inspection primarily due to signal attenuation and the presence of noise. In this work, we implemented an automatic detection workflow to analyze the time series of an earthquake sequence that has clear foreshock and aftershock activity associated with an Mw 4.0 earthquake that occurred on 3 June 2017. Further, we applied a nested grid-search algorithm to constrain the absolute earthquake locations. For about one month of data, a total of ∼1500 earthquakes were detected based on the automatic detection process, out of which ∼1000 earthquakes were locatable. All event detections, P-wave and S-wave phase readings were manually inspected and refined to ensure their quality. Previously, only about 435 events were well located based on the visual inspection approach for the same time period. Also, we analyzed repeated earthquakes based on waveform similarity leading to an improvement in the relocations of earthquakes of the aforementioned earthquake sequence. The relocated seismicity aligns parallel to a deep-reaching lineament derived from recent investigations using airborne light detection and ranging measurements.