bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biologic Prescribing Patterns Among Mount Sinai Psoriasis Patients: Results of a Retrospective Chart Review
Authors: Choy Alexa Haley , Vebman Jonathan , Yao Christopher 
Published: March 2020

Objectives: Psoriasis is a painful and chronic inflammatory skin condition that not only impacts the quality of life of patients but is also a socioeconomic burden due to the cost of treatment, particularly with biologic treatments. The purpose of the study is to understand biologic prescribing patterns among Mount Sinai psoriasis patients and assess its relationship to insurance policy, which may limit treatment access.Methods: This study reviewed randomized, de-identified charts of psoriasis patients in a nine physician academic practice at Mount Sinai (New York, United States) with the following insurers: Aetna, Blue Cross Blue Shield, Empire Blue Cross Blue Shield, Medicare A&B, and United Healthcare, treated with the following biologics: secukinumab, etanercept, adalimumab, infliximab, brodalumab, ustekinumab, ixekizumab and guselkumab. A chi-square test was performed to compare prescribed biologics by insurance policy.Results: Ustekinumab was the most prescribed biologic treatment across all the insurance plans. There were also disproportionate prescriptions of certain biologics for patients under particular insurance plans. Etanercept, brodalumab, and infliximab were the least prescribed biologics.Conclusion: Results highlight certain patterns in the prescribed biologics of Mount Sinai patients. Prescribed biologics tend to vary by different insurers. However, ustekinumab was the most frequently prescribed biologic among all insurers, though it is not the most efficacious biologic based on PASI responses. Future research should be conducted to assess how differences in insurance policies (e.g., cost to patient) affect biologic prescribing.
Review of the Prevalence of Cardiovascular and Metabolic Comorbidities of Psoriasis
Authors: Vebman Jonathan Ilai , Choy Alexa , Yao Christopher 
Published: March 2020

Introduction: Psoriasis is a common disease that is linked with several other diseases. Our goals were to analyze and present literature on prevalence of various psoriatic comorbidities, and provide an estimate of what percent of psoriasis patients might have or develop Myocardial/cardiovascular/heart disease, stroke, diabetes, obesity, hypertension, or metabolic syndrome.Method: To collect the results, we searched PubMed to identify papers that studied the frequency of the most common comorbidities of psoriasis. We used about 20. The search terms used were the particular comorbidity (or synonyms) and psoriasis. Papers were selected where the prevalence data were listed by percentages of the studied population. Prevalence data from each paper were collected and charted, and then compared. We did not use data that concerned Psoriatic Arthritis. We also recorded outliers, where frequencies did not fit with the other data found.Results: Results for prevalence of myocardial/cardiovascular/heart disease were mixed, varying by age and severity of disease. There are few papers on prevalence of stroke, but our review suggests risk of stroke increases with severity of psoriasis. The prevalence of diabetes was largely between 10% and 20%. Obesity’s prevalence was mostly between 15% and 30%, while hypertension hovered around 30%, and metabolic syndrome prevalence was mostly between 27% and 50%.Conclusions: There are many comorbidities of psoriasis. The complex interaction between cutaneous inflammation and heart disease, stroke, diabetes, hypertension, and metabolic syndrome raises many questions about cause and effect or simple association.
Risk Stratification of Severely Dysplastic Nevi by Non-Invasively Obtained Gene Expression and Mutation Analyses
Authors: Jackson Cullison Stephanie Renae , Jansen Burkhard , Yao Zuxu , Ferris Laura K 
Published: March 2020

Background: Strategies to non-invasively detect cutaneous melanoma generally focus on differentiating melanoma from non-melanoma lesions. However, given the variabilities in practice and lack of guidelines, it is important for clinicians to understand how such strategies and technologies perform on borderline lesions of uncertain clinical behavior. Objective: To evaluate LINC and PRAME gene expression and the presence of somatic mutations in BRAF, NRAS, and/or TERT in severely dysplastic nevi (SDN) and to assess, how combining gene expression and mutation analyses may impact test performance.Materials and Methods: One hundred three eligible skin lesions clinically suspicious for melanoma were non-invasively sampled via adhesive patches to enable genomic analyses. Afterward, these same lesions were immediately surgically biopsied to enable comparisons of genomic analyses with histopathologic diagnoses rendered by a panel of three dermatopathologists. Twenty-three of these lesions analyzed were deemed borderline lesions of SDN histology by at least one dermatopathologist. RNA-based gene expression positivity by Pigmented Lesion Assay (PLA) analysis was defined by detectable levels of LINC and/or PRAME. DNA-based mutation positivity was defined as detection of somatic mutations in BRAF (non-V600E), NRAS, and/or the TERT promoter. Results: Adding TERT mutation analyses to PLA gene expression increases the test’s sensitivity to rule out melanoma from 93% to 97% in this study. In addition, 61% of PLA positive lesions that were not diagnosed as melanoma were found to have severe histologic atypia. PLA-positive lesions histopathologically diagnosed as melanomas harbored TERT mutations in 70% of cases while both SDN and non-melanoma lesions including nevi without severe histologic atypia harbored TERT mutations in 4% of cases. BRAF non-V600E and NRAS mutations were only found in the melanoma group and adding these mutations did not further enhance the test’s sensitivity. Conclusions and Relevance: PLA positivity increases with histologic atypia of pigmented skin lesions. Combining TERT mutation analyses with melanoma-associated gene expression provides additional genetic information to further non-invasively risk-stratify pigmented lesions. These findings furthermore support that pigmented lesions exist on a spectrum of genomic atypia that may prove useful in identifying borderline lesions beyond their morphological appearance.
Potency of Combination of Fucoidan Microsphere and MiRNA-200b as Therapy in Chemoresistant Breast Cancer
Authors: Wiranata Sinta , Yani Made VW , Satyarsa Agung Bagus S , Ardiana I Ketut R , Adiputra Putu AT 
Published: March 2020

Breast cancer still become a major health problem in Indonesia and worldwide until today. Based on WHO 2012, breast cancer incidence is reported as 1.67 million cases with 90% of mortality rate in the metastasis stage. Chemoresistant is one cause of this increased mortality and morbidity. Nowadays, there are many treatment choices for cancer, but 90% incident of chemoresistant breast cancer occur even with prior chemotherapy. This review aimed to describe the potential of microsphere combinations fucoidan and miRNA-200b as a treatment for chemoresistant in breast cancer. Literature review were derived from scientific journals using www.pubmed.com and scholar.google.com database with “chemoresistant breast cancer, Fucoidan, microRNA-200b” as keyword. Fucoidan can induce apoptosis through the extrinsic pathway involving apoptotic receptor, or intrinsic pathway involving changes in mitochondrial membrane potential (MMP) to release cytochrome C and activating the apoptotic signal. Meanwhile, miRNA-200b expression, will decrease Sp1 expression and decrease histone-3 acetylation level in a miRNA-200b promoter, resulting in decreased cancer cell migration and invasion. However, no studies have evaluated this combination clinically. So, further studies are needed to confirm the potential of microsphere combination fucoidan and miRNA-200b in chemoresistant breast cancer.

Keywords: chemoresistant breast cancer; Fucoidan; miRNA-200b.
Understanding Patients with Type 2 Diabetes Mellitus Using Oral Antidiabetic Drugs
Authors: Irene Grace Y , Kuswinarti Kuswinarti , Kusumawati Maya 
Published: March 2020

Uncontrolled hyperglycemia in people with diabetes mellitus can increase the risk of diabetes complications and comorbidities. This study aimed to determine the demographic, clinical, history, complications, and comorbid characteristics of diabetes. The study was conducted with a descriptive method and cross-sectional research design. Data were collected retrospectively using medical record data and using the Finite Population Correction formula with a sample of 115. The results showed the majority of patients were female (67.8%), aged ? 65 years (40.0%), residing in urban (87.6%), high school graduates (35.2%), and unemployed (63.6%). Patients generally have a normal BMI (45.9%) and have several variables that reach the target, namely fasting blood glucose (50.4%), triglycerides (55.3%), and creatinine (69.6%). Patients also had several variables that did not reach the target, namely postprandial 2 hour blood glucose (51.3%), blood pressure (65.8%), total cholesterol (55.6%), HDL cholesterol (54.5%), LDL cholesterol (80.0%), and urea (56.0%). Patients who use oral anti-diabetes generally have used it <5 years (76.3%) and used monotherapy (63.5%). Neuropathy (42.6%) and hypertension (85.9%) were the most common complications and comorbidities of diabetes in this study. Strict glycemic control is an important management for people with diabetes mellitus.

Keywords: oral antidiabetic drugs; diabetes mellitus; comorbid
Combination of Cisplatin-Withaferin Based on PEGylated Liposome Nanoparticles as Alternative Therapy for Ovarian Cancer
Authors: Yani Made VW , Anjani Ida Ayu W , Narayana I Gede S , Wihandani Desak M , Supadmanaba I Gede P 
Published: March 2020

Ovarian cancer is one of the major health problems in gynecology worldwide. Globocan 2012 data shows that ovarian cancer occurs in 239.000 cases, and is placed fourth as the most malignancy occurred in Indonesia. So far, cisplatin is the most effective therapeutic agent, but the high dosage of administration often caused side effects. A new alternative therapy to overcome the problems by using withaferin-A and nanoparticle PEGylated liposome. WFA has the potential effect to reduce cisplatin resistance but has low bioavailability thus, it needs to be encapsulated. This review’s goal is to depict the potency of withaferin-A, cisplatin, and PEGylated liposome combination as a therapeutic agent to treat ovarian cancer. The combination of Cisplatin-Withaferin PEGylated Liposome is constructed by the modified thin lipid film hydration method then administered orally. This combination suppresses 70-80% of the ovarian cancer cell growth in vivo and inhibits NGFR from binding to TRKA, prevents cell migration as much as 50%. Nano-Cisferin-Liposome, inhibits migration of ovarian cancer cell significantly through ?-catenin signaling through ALDH1 that disturb the spheroid formation, and increase apoptosis event as much 70-80% by increasing ROS production up to 2,5 times. Thus, Nano-Cisferin-Liposome (NCL) has potential as a therapeutic agent for treating ovarian cancer.

Keywords: Cisplatin; Ovarian Cancer; PEGylated Liposome; Withaferin A
The Effects of Kinesio Taping and Quadriceps Muscle Strengthening Exercise on Quadriceps Muscle Strength and Functional Status in Knee Osteoarthritis
Authors: Nayanti Anggia P , Prabowo Tertianto , Sari Dian M 
Published: March 2020

Knee Osteoarthritis (KOA) is characterized by knee cartilage degradation. Knee Osteoarthritis symptoms are joint pain, stiffness, quadriceps muscle weakness and daily activities difficulties. The use of Kinesio Taping (KT) in Quadriceps muscle strengthening exercises (QSE) is known to increase quadriceps muscle strength, reduce pain and improve functional abilities in KOA. This study aimed to determine the effect of KT with QSE on quadriceps muscle strength and functional status in KOA. This is a double-blind randomized controlled trial, involving twenty-six KOA women that were divided equally into treatment and control groups. The treatment group was given KT and QSE, the control group received sham taping and QSE. Quadriceps muscle strength and WOMAC scores were measured before and after treatment at 4, 6 and 8 weeks. There was a significant difference in quadriceps muscle strength at the 6th week (p = 0.019) between treatment and control groups and no significant differences (p> 0.05) in the strength of quadriceps muscle at 4th and 8th weeks and WOMAC values ??at 4th, 6th and 8th weeks. We concluded that a combination of KT with QSE offers advantages for improvement of quadriceps muscle strength at 6th week but not for functional status in KOA.

Keywords: Kinesio taping, Osteoarthritis, Strengthening exercises, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
A Case of Lupus Vulgaris Diagnosed without Skin Biopsy
Authors: Puspitasari Dian , Henrica Feilicia 
Published: March 2020

Lupus vulgaris is a variant of cutaneous tuberculosis in a previously sensitized individual that has a high degree of delayed-type hypersensitivity to tuberculin. Absolute criteria for the diagnosis of cutaneous tuberculosis is a positive M. tuberculosis culture on guinea pig or polymerase chain reaction (PCR) examination. We reported a case of lupus vulgaris in a 32 years old female. A diagnosis of lupus vulgaris was made by clinical manifestation, therapeutic trial, interferon-gamma release assay (IGRA) test, and other laboratory tests. The patient presented with an erythematous scaly plaque on the face and left hand. Diascopy test was positive, consistent with the “apple jelly” sign. Regression of lesion was observed after 1 month of therapy with anti-tuberculosis drugs. Culture, PCR, and histopathological examination were not established due to patient’s refusal. The patient was allergic to pyrazinamide and ethambutol, therefore she was initially treated with a daily dose of 450 mg Rifampicin, 300 mg isoniazid (INH), and 500 mg levofloxacin for 2 months and continued with maintenance phase, three times weekly of 450 mg Rifampicin and 450 mg INH until one year. Treatment provided a good result.

Keywords: tuberculosis; lupus vulgaris; therapeutic trial
Comprehensive Treatment for Eight Years Old Child with Rampant Caries
Authors: Yusuf Triana N , Jeffrey Jeffrey 
Published: March 2020

The prevalence of dental caries in Indonesia primary school is 60-80%. Dental caries is a continuous dynamic process involving repeating periods of demineralization by organic acids of microbial origin and subsequent remineralization by salivary components, but in which the overall environment is imbalanced towards demineralization. Rampant caries is a sign of gross dietary inadequacy, complete absence of oral hygiene practice or systemic illness. Rampant caries is suddenly appearing, widespread, rapidly burrowing type of caries, resulting in early involvement of the pulp and affecting those teeth usually regarded as immune to ordinary decay. This case report presents a case of rampant caries in an 8-year-old boy and the treatment. The cooperative behavior of patients and parents is needed for optimal results.

Keywords: Rampant caries; caries in children; caries
Influencing Factors of Hearing Disorder in Helicopter and Casa Pilots
Authors: Nurfitriyana Nurfitriyana , Ivone July , Adhy Pramusinto 
Published: March 2020

Noise-Induced Hearing Loss (NIHL) is a hearing disorder caused by noise. Noise with the intensity of 85 decibels (dB)or higher may damage the corti hearing receptor. Pilot is one of the riskiest occupations due to frequent noise exposure from aircraft machine. This research aimed to identify the influence of aircraft noise levels on hearing disorder of both helicopter and casa pilots. This is observational analytical research with cross-sectional design, involving 30 helicopter pilots and 30 casa pilots. The diagnosis of hearing disorder was done using secondary data from medical records. The aircraft noise was measured by sound level meter, the other risk factors were observed with questionnaire. Data were analyzed by chi-square with ?=0,05. The results showed that aircraft noise (p=0,009; OR=4,929), duration of working period (p=0,026; OR=8,308), and flight hours (p=0,006; OR=3,222) were related with hearing disorder, but not age (p=0,093; OR=3,222). We concluded aircraft noise, duration of the working period, and flight hours are related to hearing disorder of the pilots.

Keywords: hearing disorder; pilot; noise; noise-induced hearing loss
Hubungan Tingkat Kebiasaan Merokok dengan Stadium Katarak Senilis di Poliklinik Katarak dan Bedah Refraktif (KBR) Rumah Sakit Mata Cicendo Bandung
Authors: Muliani Rizki , Simanjuntak Rosdiana , Jundiah Siti 
Published: March 2020

Katarak merupakan penyebab utama kebutaan di dunia, termasuk Indonesia. Katarak senilis adalah katarak yang paling sering ditemukan. Katarak senilis merupakan proses penuaaan dengan banyak faktor yang terlibat pada kematangan katarak senilis seperti faktor keturunan, radiasi ultraviolet, pola makan, krisis dehidrasi, dan merokok. Merokok adalah salah satu penyebab yang terlibat pada kematangan katarak senilis karena merokok menyebabkan penumpukan molekul berpigmen -3 hydroxykhynurine dan chromophores yang menyebabkan terjadinya penguningan warna lensa. Penelitian ini bertujuan untuk mengetahui hubungan tingkat kebiasaan merokok dengan stadium katarak senilis. Jenis penelitian yang digunakan adalah penelitian deskriptif korelatif dengan pendekatan cross sectional. Subjek penelitian adalah pasien katarak senilis yang berobat di Poliklinik Katarak dan Bedah Refraktif (KBR) Rumah Sakit Mata Cicendo Bandung, Indonesia, yang memiliki kebiasaan merokok. Sebanyak 337 pasien dilibatkan pada penelitian ini dengan teknik pengambilan sampel purposive sampling. Pengumpulan data dilakukan melalui wawancara dan pengambilan data rekam medis. Analisis data dilakukan menggunakan Chi-square. Hasil penelitian menunjukkan 61,7% pasien adalah perokok ringan dan 66,2% adalah pasien dengan katarak senilis imatur. Dari hasil uji Chi-square didapatkan nilai p = 0,000 sehingga dapat disimpulkan ada hubungan antara tingkat kebiasaan merokok dengan stadium katarak senilis.

Kata kunci: katarak; stadium katarak senilis; merokok
Uji Aktivitas Antibakteri Ekstrak Metanol, Ekstrak Fraksi N-Heksan dan Ekstrak N-Heksan Daun Filicium decipiens terhadap Bakteri Staphylococcus aureus dan Bakteri Bacillus subtilis
Authors: Mahyuni Siti , Sofihidayati Trirakhma 
Published: March 2020

Ekstrak etanol tanaman Filicium decipiens diketahui memiliki aktivitas antibakteri kuat terhadap Staphylococcus aureus, namun belum ada penelitian aktivitas antibakteri ekstrak F. decipiens dengan pelarut berbeda. Tujuan penelitian ini mengetahui aktivitas anti bakteri ekstrak metanol, fraksi n-heksan ekstrak metanol dan ekstrak n-heksan daun F. decipiens terhadap bakteri S. aureus dan bakteri Bacillus subtilis. Ekstraksi dilakukan dengan metode soxletasi menggunakan pelarut metanol dan n-heksan. Uji aktivitas anti bakteri dilakukan dengan mengukur konsentrasi hambat minimum (KHM) dan lebar daerah hambat (LDH). Hasil penelitian menunjukkan bahwa ekstrak metanol tidak memiliki aktivitas baik terhadap bakteri S. aureus maupun terhadap B. subtilis. Ekstrak n-heksan yang difraksinsi dari ekstrak metanol tidak memiliki aktivitas terhadap B. subtilis namun menunjukkan aktivitas sedang terhadap bakteri S. aureus dengan LDH tertinggi 9 mm pada konsentrasi ekstrak 40%. Ekstrak n-heksan memiliki aktivitas antibakteri yang sangat kuat terhadap S. aureus dengan diameter hambat mencapai 21 mm pada konsentrasi 30% dan menunjukkan aktivitas kuat terhadap B. subtilis dengan diameter hambat 10 mm pada konsentrasi 30%. Dapat disimpulkan bahwa ekstrak n-heksan F. decipiens memiliki aktivitas antibakteri paling kuat dibandingkan dengan ekstrak metanol dan ekstrak fraksi n-heksan.

Kata kunci: Filiciums decipiens, Staphylococcus aureus, Bacillus subtilis, ekstrak n-hexan, ekstrak metanol
Peningkatan Fungsi Atensi dan Memori Jangka Pendek pada Wanita Dewasa Muda dengan Ansietas setelah Terapi Mewarnai
Authors: Krisnanda Moses A , Hasianna Stella T , Limyati Yenni 
Published: March 2020

Kecemasan dapat mempengaruhi fungsi atensi dan memori. Tujuan penelitian ini adalah untuk mengetahui pengaruh terapi mewarnai terhadap peningkatan fungsi atensi dan memori jangka pendek pada wanita dewasa muda dengan ansietas. Penelitian ini menggunakan metode analitik eksperimental kuasi yang bersifat komparatif dengan rancangan pre-test dan post-test. Data yang diukur adalah atensi (skor Stroop test) dan memori jangka pendek (skor Scenery Picture Memory Test / SPMT). Subjek penelitian ini adalah 25 orang mahasiswi dengan ansietas (skor A pada kuesioner Depression Anxiety Stress Scale / DASS-42 ?8). Hasil penelitian rerata skor Stroop test pada pre-test dan post-test adalah 136,20 dan 72,60 detik, sedangkan rerata skor SPMT pada pre-test dan post-test adalah 17,88 dan 20,92. Penelitian ini menggunakan uji analisis statistik Wilcoxon dengan nilai ?=0,05 dan menunjukkan hasil nilai p 0,000 untuk skor Stroop test dan SPMT (sangat signifikan). Simpulan penelitian ini adalah terapi mewarnai meningkatkan fungsi atensi dan memori jangka pendek pada wanita dewasa muda dengan ansietas.

Kata Kunci: terapi mewarnai, atensi, memori jangka pendek, kognitif, ansietas
The Effect of Bee Pollen on SGOT, SGPT Levels and Liver Histopathological Images of Male Rats Wistar Induced by High Fat Diet
Authors: Prahastuti Sijani , Ladi Jeanny E , Dewi Kartika , Albertina Felicia , Imam Muhammad K 
Published: March 2020

Dyslipidemia is a risk factor for Non Alcoholic Fatty Liver Disease causing hepatocyte damage. Bee pollen has hypolipodemic, anti-inflammatory effects. The purpose of the study was to analyze the effects of Bee Pollen on the levels of SGOT, SGPT, and its effects on the liver’s histopathologic. The experimental laboratory research method, 30 rats divided into 6 groups (n = 5). HFD was given for 28 days, Simvastatin and Bee Pollen were given from 15 until 28 days. SGOT, SGPT were examined at 0, 15, 29 days by spectrophotometry (340 nm). Histopathological liver examination at 29 days. Results: The levels of SGOT, SGPT between Bee pollen 1 (18 mg/kgBW/day), 2 (36 mg /kgBW/day), 3 (72 mg /kgBW/day) with HFD were very significant differences. The levels of SGOT Bee Pollen 1,2,3 compared to simvastatin were not significantly different. SGPT Bee Pollen 3 levels compared to simvastatin there were no significant differences. Measurement of the degree of cloudy swollen cells, portal inflammation, bridging fibrosis, periportal fibrosis between Bee Pollen 1, 2 with HFD there is a significant difference, Bee Pollen 3 and HFD differ very significantly. Conclusion: Bee Pollen can reduce levels of SGOT, SGPT, its potential effects is equivalent to simvastatin on reducing levels of SGOT, SGPT and improved the histopathological image of the liver on male rats wistar induced by high-fat diet. .

Keywords : Dyslipidemia, SGOT, SGPT, Bee pollen, Histopatological Image