bluuebunny/crossref_metadata_2025_split huggingface dataset:
On cycling risk and discomfort: urban safety mapping and bike route recommendations
Authors: Castells-Graells David , Salahub Christopher , Pournaras Evangelos 
Published: December 2019

AbstractBike usage in Smart Cities is paramount for sustainable urban development: cycling promotes healthier lifestyles, lowers energy consumption, lowers carbon emissions, and reduces urban traffic. However, the expansion and increased use of bike infrastructure has been accompanied by a glut of bike accidents, a trend jeopardizing the urban bike movement. This paper leverages data from a diverse spectrum of sources to characterise geolocated bike accident severity and, ultimately, study cycling risk and discomfort. Kernel density estimation generates a continuous, empirical, spatial risk estimate which is mapped in a case study of Zürich city. The roles of weather, time, accident type, and severity are illustrated. A predominance of self-caused accidents motivates an open-source software artifact for personalized route recommendations. This software is used to collect open baseline route data that are compared with alternative routes minimizing risk and discomfort. These contributions have the potential to provide invaluable infrastructure improvement insights to urban planners, and may also improve the awareness of risk in the urban environment among experienced and novice cyclists alike.
Diagnostic performance of diffusion-weighted magnetic resonance imaging in assessing lymph node metastasis of esophageal cancer compared with PET
Authors: Shuto Kiyohiko , Kono Tsuguaki , Shiratori Toru , Akutsu Yasunori , Uesato Masaya , Mori Mikito , Narushima Kazuo , Imanishi Shunsuke , Nabeya Yoshihiro , Yanagawa Noriyuki , Okazumi Shinichi , Koda Keiji , Matsubara Hisahiro 
Published: December 2019

Abstract
Background
Although diffusion-weighted magnetic resonance imaging (DWI) for detecting lymph node (LN) metastasis is reported to be a successful modality for primary malignant tumors, there are few studies relating to esophageal cancer. This study aimed to clarify the diagnostic performance of DWI for assessing LN metastasis compared with positron emission tomography (PET) in patients with esophageal squamous cell cancer (eSCC).

Methods
Seventy-six patients with histologically proven eSCC who underwent curative esophagectomy without neoadjuvant treatment were reviewed retrospectively. Harvested LNs were divided into 1229 node stations with 94 metastases. Diagnostic abilities and prognostic significance were compared.

Results
In a station-by-station evaluation, the sensitivity was higher in DWI than PET (67% vs. 32%, P < 0.001). DWI showed more than 80% sensitivity for middle- and large-sized cancer nests and large area of cancer nests. The DWI-N0 group had a better 5-year relapse-free survival rate than the DWI-N+ group (78.5% vs. 34.2%, P < 0.001), as did the PET-N0 group. DWI-N status was an independent prognostic factor (hazard ratio [HR], 2.642; P = 0.048), as was PET-N status (HR 2.481; P = 0.033).

Conclusions
DWI, which depends on cancer cell volume followed by elevated intranodal density, is a non-invasive modality and showed higher sensitivity than PET. It has clinical impact in predicting postoperative survival for patients with eSCC alongside its diagnostic ability and has significant performance in clinical practice.
Symptomatic and Functional Remission in Young Adults with a Psychotic Disorder in a Rehabilitation Focused Team
Authors: Kwakernaak Sascha , Swildens Wilma E. , van Wel Tom F. , Janssen Richard T. J. M. 
Published: December 2019

AbstractThe aim of this study is to assess symptomatic remission (SR) and functional remission (FR) in a rehabilitation focused program for young adults with a psychotic disorder in the Netherlands, and to investigate which individual and mental health care factors are associated with SR and/or FR, by using Routine Outcome Monitoring data and data on met needs and unmet needs for care. Data of 287 young adults were collected. Almost 40% achieved or maintained SR, 34% FR, and 26% achieved or maintained both. In addition to sociodemographic factors, living independently, paid employment, higher levels of compliance with treatment, and better fulfillment of unmet needs for care in relation to psychological distress, company and daytime activities were associated with better outcomes on SR and/or FR. Our findings underscore that to successfully improve and sustain remission in young adults with a psychotic disorder, it is needed to conduct specific research into the relationship between SR and FR.
Is Camouflaging Autistic Traits Associated with Suicidal Thoughts and Behaviours? Expanding the Interpersonal Psychological Theory of Suicide in an Undergraduate Student Sample
Authors: Cassidy S. A. , Gould K. , Townsend E. , Pelton M. , Robertson A. E. , Rodgers J. 
Published: December 2019

AbstractThe current study explored whether people who camouflage autistic traits are more likely to experience thwarted belongingness and suicidality, as predicted by the Interpersonal Psychological Theory of Suicide (IPTS). 160 undergraduate students (86.9% female, 18–23 years) completed a cross-sectional online survey from 8th February to 30th May 2019 including self-report measures of thwarted belongingness and perceived burdensomeness, autistic traits, depression, anxiety, camouflaging autistic traits, and lifetime suicidality. Results suggest that camouflaging autistic traits is associated with increased risk of experiencing thwarted belongingness and lifetime suicidality. It is important for suicide theories such as the IPTS to include variables relevant to the broader autism phenotype, to increase applicability of models to both autistic and non-autistic people.
Thallus sectioning as an efficient monospore release method in Pyropia yezoensis (Bangiales, Rhodophyta)
Authors: Chen Nianci , Tang Lei , Guan Xiaowei , Chen Rui , Cao Min , Mao Yunxiang , Wang Dongmei 
Published: December 2019

AbstractThe red seaweed Pyropia yezoensis is a marine crop of important economic value and is widely cultivated in the coastal areas of northern China. The current seedling-raising system relies on the germination of conchospores, a process not fast enough to meet the increasing demand from farmers. In this study, we developed a monospore-dependent seedling method based on the asexual reproduction of the Pyropia thallus. The Pyropia thallus was physically sectioned into small pieces (microthalli) that were cultivated at 15 °C. The algal cells in the microthalli became morphologically condensed, underwent cell division, and then developed into monospores on the 5th day. The monospores were able to attach to the seeding rope in 24 h and germinated into healthy thalli. To optimize the efficiency of monospore release, we tested the effect of temperature and the size and original positions of the microthalli as well as the age of the mother thallus. Microthalli with a size of 30–50 cells from the middle and apex of 21-day-old thalli cultivated at 15 °C yielded the optimum production of monospores. Theoretically, in this thallus-to-thallus seeding strategy, 0.1 g of thallus could produce at least 107 monospores, with the same number of offspring thallus seedlings. Taking all of these advantages together, including the high efficiency, short time, low cost and easy operation, this physical sectioning method could serve as a promising seed source especially for new cultivars with superior traits in Pyropia farming and rapid replenishment of seedlings when thalli undergo disastrous diseases.
Employment in Personality Disorders and the Effectiveness of Individual Placement and Support: Outcomes from a Secondary Data Analysis
Authors: Juurlink T. T. , Lamers F. , van Marle H. J. F. , Michon H. , van Busschbach J. T. , Beekman A. T. F. , Anema J. R. 
Published: December 2019

AbstractPurpose Personality disorders (PDs) are associated with severe functional impairment and subsequent high societal costs, increasing the need to improve occupational functioning in PD. Individual placement and support (IPS) is an effective, evidence-based method of supported employment, which so far has been tested in various mixed patient populations with severe mental illness (SMI, including PDs). However, the effectiveness of IPS for PDs per se remains uninvestigated. Methods Data from the SCION trial were used, including 31 SMI patients with PDs and 115 SMI patients with other primary diagnoses (primarily psychotic disorders). First, the interaction effect of diagnosis (PD vs other SMI) and intervention (IPS vs traditional vocational rehabilitation) was studied. Second, in the IPS condition, difference between diagnostic groups in time to first job was studied. Results We did not find evidence of a moderating effect of PD diagnosis on the primary effect of IPS (proportion who started in regular employment) (OR = 0.592, 95% CI 0.80–4.350, p = 0.606) after 30 months. Also, PD diagnosis did not moderate the effect of time until first job in IPS. Conclusions From the present explorative analysis we did not find evidence for a moderating effect of PD diagnosis on the effectiveness of IPS among PD participants. This indicates that IPS could be as effective in gaining employment in participants with PD as it is in participants with other SMI. Future studies, implementing larger numbers, should confirm whether IPS is equally effective in PDs and study whether augmentations or alterations to the standard IPS model might be beneficiary for PD.
Structural problems for reductionism
Authors: Leuenberger Stephan 
Published: December 2019

AbstractUniversal reductionism—the sort of project pursued by Carnap in the Aufbau, Lewis in his campaign on behalf of Humean supervenience, Jackson in From Metaphysics to Ethics, and Chalmers in Constructing the World—aims to reduce everything to some specified base, more or less austere as it may be. In this paper, I identify two constraints that a promising strategy to argue for universal reductionism needs to satisfy: the exhaustion constraint and the chaining constraint. As a case study, I then consider Chalmers’ Constructing the World, in which a priori implication, or “scrutability”, plays the role of reduction. Chalmers first divides up the total vocabulary of our language into different families, and then argues, for each family separately, that truths involving expressions in that family are scrutable from the putative base. He does not systematically address the question whether “cross-family sentences”—sentences involving expressions from more than one family—are scrutable. I shall argue that this lacuna cannot be filled, since scrutability does not allow for the exhaustion constraint and the chaining constraint to be jointly satisfied. I further suggest that Carnap’s account, in which definability plays the role of reduction, has better prospects of meeting these constraints.
Determinants of health-related quality of life proxy rating disagreement between caregivers of children with cancer
Authors: Rensen Niki , Steur Lindsay M. H. , Schepers Sasja A. , Merks Johannes H. M. , Moll Annette C. , Kaspers Gertjan J. L. , Van Litsenburg Raphaële R. L. , Grootenhuis Martha A. 
Published: December 2019

Abstract
Purpose
Proxy reports of health-related quality of life (HRQoL) are commonly used in pediatric oncology. However, it is not known if caregivers’ reports differ. This study therefore aims to compare paternal and maternal proxy reports, and explore determinants of couple disagreement (sociodemographic and medical characteristics, and parental QoL and distress).

Methods
Both parents completed the PedsQL generic (child’s HRQoL), Short Form-12 (own QoL) and Distress Thermometer for Parents. To assess agreement in child HRQoL, intra-class correlation coefficients (ICCs) were calculated. Differences between fathers/mothers were assessed with paired t tests. Systematic disagreement patterns were visualized with Bland–Altman plots. Characteristics of parental couples with a mean proxy difference in the highest quartile (highest proxy score minus lowest proxy score) were explored with multiple logistic regression analysis.

Results
Parents of 120 children with cancer (87% post-treatment, mean age 11.0 ± 5.7 years) participated. No significant differences were found between paternal and maternal proxy scores, and agreement was good on all scales (ICCs 0.65–0.83). Bland–Altman plots revealed no systematic disagreement patterns, but there was a wide range in magnitude of the differences, and differences went in both directions. Couples with a mean proxy difference (irrespective of which direction) in the highest quartile (± 20 points) were more likely to have a child in active treatment, with retinoblastoma or relapsed disease, and to diverge in their own QoL.

Conclusions
If proxy reports of only one parent are available, clinicians may reasonably assume that paternal and maternal reports are interchangeable. However, if in doubt, respondent’s sex is not of major importance, but clinicians should be aware of patient’s and family’s characteristics.
Decision Tree-Based Data Mining and Rule Induction for Identifying High Quality Groundwater Zones to Water Supply Management: a Novel Hybrid Use of Data Mining and GIS
Authors: Jeihouni Mehrdad , Toomanian Ara , Mansourian Ali 
Published: December 2019

AbstractGroundwater is an important source to supply drinking water demands in both arid and semi-arid regions. Nevertheless, locating high quality drinking water is a major challenge in such areas. Against this background, this study proceeds to utilize and compare five decision tree-based data mining algorithms including Ordinary Decision Tree (ODT), Random Forest (RF), Random Tree (RT), Chi-square Automatic Interaction Detector (CHAID), and Iterative Dichotomiser 3 (ID3) for rule induction in order to identify high quality groundwater zones for drinking purposes. The proposed methodology works by initially extracting key relevant variables affecting water quality (electrical conductivity, pH, hardness and chloride) out of a total of eight existing parameters, and using them as inputs for the rule induction process. The algorithms were evaluated with reference to both continuous and discrete datasets. The findings were speculative of the superiority, performance-wise, of rule induction using the continuous dataset as opposed to the discrete dataset. Based on validation results, in continuous dataset, RF and ODT showed higher and RT showed acceptable performance. The groundwater quality maps were generated by combining the effective parameters distribution maps using inducted rules from RF, ODT, and RT, in GIS environment. A quick glance at the generated maps reveals a drop in the quality of groundwater from south to north as well as from east to west in the study area. The RF showed the highest performance (accuracy of 97.10%) among its counterparts; and so the generated map based on rules inducted from RF is more reliable. The RF and ODT methods are more suitable in the case of continuous dataset and can be applied for rule induction to determine water quality with higher accuracy compared to other tested algorithms.
Prenucleation at the Interface Between MgO and Liquid Magnesium: An Ab Initio Molecular Dynamics Study
Authors: Fang C. M. , Fan Z. 
Published: December 2019

Abstract
Magnesia (MgO) particles inevitably exist in liquid Mg and may be used as potential sites for heterogeneous nucleation to achieve effective grain refinement. Understanding of the atomic configurations on MgO surfaces and in the liquid Mg adjacent to the liquid Mg/MgO interfaces is therefore of both scientific and practical interests. We investigate the surface structures of MgO in liquid Mg and the atomic arrangements of liquid Mg adjacent to liquid/substrate interfaces, using an ab initio molecular dynamics (MD) simulation technique. We find that an atomically rough terminating Mg layer forms on the {1 1 1} terminated MgO substrate (octahedral MgO) in liquid Mg. The simulations also reveal that on the structurally flat {0 0 1} terminated MgO substrate (cubic MgO) a rough Mg layer forms due to the unique chemical interactions between the ions on the substrate and the liquid metals. The surface roughness together with the large lattice misfits with solid Mg makes both octahedral and cubic MgO substrates impotent for heterogeneous nucleation of α-Mg. The present results may shed new light on grain refinement of Mg-alloys.
What the HLA-I!—Classical and Non-classical HLA Class I and Their Potential Roles in Type 1 Diabetes
Authors: Wyatt Rebecca C. , Lanzoni Giacomo , Russell Mark A. , Gerling Ivan , Richardson Sarah J. 
Published: December 2019

Abstract
Purpose of Review
Hyperexpression of classical HLA class I (HLA-I) molecules in insulin-containing islets has become a widely accepted hallmark of type 1 diabetes pathology. In comparison, relatively little is known about the expression, function and role of non-classical subtypes of HLA-I. This review focuses on the current understanding of the non-classical HLA-I subtypes: HLA-E, HLA-F and HLA-G, within and outside the field of type 1 diabetes, and considers the possible impacts of these molecules on disease etiology.

Recent Findings
Evidence is growing to suggest that non-classical HLA-I proteins are upregulated, both at the RNA and protein levels in the pancreas of individuals with recent-onset type 1 diabetes. Moreover, associations between non-classical HLA-I genotypes and age at onset of type 1 diabetes have been reported in some studies. As with classical HLA-I, it is likely that hyperexpression of non-classical HLA-I is driven by the release of diffusible interferons by stressed β cells (potentially driven by viral infection) and exacerbated by release of cytokines from infiltrating immune cells.

Summary
Non-classical HLA-I proteins predominantly (but not exclusively) transduce negative signals to immune cells infiltrating at the site of injury/inflammation. We propose a model in which the islet endocrine cells, through expression of non-classical HLA-I are fighting back against the infiltrating immune cells. By inhibiting the activity and function on NK, B and select T cells, the non-classical HLA-I, proteins will reduce the non-specific bystander effects of inflammation, while at the same time still allowing the targeted destruction of β cells by specific islet-reactive CD8+ T cells.
In Vivo Tumor Growth Inhibition and Antiangiogenic Effect of Cyclic NGR Peptide-Daunorubicin Conjugates Developed for Targeted Drug Delivery
Authors: Tripodi Andrea Angelo Pierluigi , Ranđelović Ivan , Biri-Kovács Beáta , Szeder Bálint , Mező Gábor , Tóvári József 
Published: December 2019

AbstractAmong various homing devices, peptides containing the NGR tripeptide sequence represent a promising approach to selectively recognize CD13 receptor isoforms on the surface of tumor cells. They have been successfully used for the delivery of various chemotherapeutic drugs to tumor vessels. Here, we report on the murine plasma stability, in vitro andin vivoantitumor activity of our recently described bioconjugates containing daunorubicin as payload. Furthermore, CD13 expression of KS Kaposi’s Sarcoma cell line and HT-29 human colon carcinoma cell line was investigated. Flow cytometry studies confirm the fast cellular uptake resulting in the rapid delivery of the active metabolite Dau = Aoa-Gly-OH to tumor cells. The increased in vitro antitumor effect might be explained by the faster rearrangement from NGR toisoDGR in case of conjugate2(Dau = Aoa-GFLGK(c[NleNGRE]-GG)-NH2) in comparison with conjugate1(Dau = Aoa-GFLGK(c[KNGRE]-GG)-NH2). Nevertheless, results indicated that both conjugates showed significant effect on inhibition of proliferation in the primary tumor and also on blood vessel formation making them a potential candidate for targeting angiogenesis processes in tumors where CD13 and integrins are involved.
Effect of Smartphone-Based Telemonitored Exercise Rehabilitation among Patients with Coronary Heart Disease
Authors: Song Yanxin , Ren Chuan , Liu Ping , Tao Liyuan , Zhao Wei , Gao Wei 
Published: December 2019

AbstractThe aim of this study was to investigate the effects of telemonitored exercise rehabilitation on patients with coronary heart disease (CHD) in China. Ninety-six patients with stable CHD were included and analyzed (48 in telemonitored group and 48 in control group). All patients received routine follow-up, and patients in telemonitored group participated in smartphone-based telemonitored cardiac rehabilitation. Patients’ demographic information, medical history, diagnosis and treatment of CHD, and laboratory results were collected. The difference of cardiopulmonary exercise testing (CPET), blood test, and echocardiographic parameters; exercise habits; control rate of blood lipid and blood glucose; and incidence of adverse events between the two groups during 6 months of follow-up was analyzed. After intervention, the subjects in the telemonitored group performed significantly better in VO2peak, exercise compliance, and some other parameters than those in the control group. Telemonitored exercise rehabilitation is an effective rehabilitation mode for CHD patients in China.
Geothermal sources and utilization practice in six countries along the southern part of the Pannonian basin
Authors: Rman Nina , Bălan Lidia-Lenuța , Bobovečki Ivana , Gál Nóra , Jolović Boban , Lapanje Andrej , Marković Tamara , Milenić Dejan , Skopljak Ferid , Rotár-Szalkai Ágnes , Samardžić Natalija , Szőcs Teodóra , Šolaja Dragana , Toholj Nenad , Vijdea Anca-Marina , Vranješ Ana 
Published: December 2019

AbstractData on thermal water sources with outflow temperature of 30 °C and above were analyzed from the N-ern parts of Bosnia and Herzegovina, Serbia and Croatia, S-ern parts of Hungary, W-ern parts of Romania, and NE-ern parts of Slovenia, altogether from an area of 99,347 km2. The overview identified 771 geothermal sources; only 7 were thermal springs. The average well depth is about 1.2 km. About 13% of wells are younger than 10 years, additional 17% below 30 years; while 26% are older than 50 years. Average thermal water outflow temperature is 54 °C being the highest, 170 °C, in Croatia. Most thermal water is produced from basin fill sediments—Lower and Upper Pannonian (Mio-Pliocene) loose sandstones which are tapped by 86% of wells. The rest appertains to basement rocks—fissured, fractured and karstified Paleozoic, Mesozoic and Middle Miocene metamorphic, carbonate and siliciclastic rocks. In total, 72% sources hold water rights, 6% mining rights, 2% geothermal rights and 1% has no rights. The permits allow much higher water abstraction as currently listed. Usage for bathing and balneology encompasses 24% of all active sources (155), some of these also with heating (23). 104 objects (16%) are used for heating, also district heating (13) and individual space heating (3). An additional 10% (70) are used in agriculture, mainly greenhouse heating. There are 41 reinjection wells (5%). It is primarily in Hungary that drinking water (17%), industrial usage (5%) and monitoring wells (2%) are also common.