bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectral signature of solar active region in millimetre and submillimetre wavelengths
Authors: Valle Silva J F , Giménez de Castro C G , Selhorst C L , Raulin J-P , Valio A 
Published: October 2020

ABSTRACT
Active regions were observed with different instruments covering the spectral band from 17 to 405 GHz. The observations were made with the Nobeyama Radioheliograph (17 GHz), the Atacama Large Millimetre Array (107 and 238 GHz), and the Solar Submillimeter Telescope (212 and 405 GHz). A procedure was developed that allows the comparison between observations taken with telescopes of different operational characteristics and mainly of different spatial resolution. The brightness temperature and density flux spectra of several active regions corresponding to a different phase of its lifetime were obtained. The flux density invariably increases in all cases from 107 to 405 GHz and the mean spectral index is ∼2 showing that the dominant emission mechanism at submillimeter frequencies is still thermal. We show that Solar Submillimeter Telescope (SST) and Atacama Large Millimeter/submillimeter Array (ALMA) observations are compatible within the uncertainties, a result of great interest for future joint observations.
A multiwavelength study of the dual nuclei in Mrk 212
Authors: Rubinur K , Kharb P , Das M , Rahna P T , Honey M , Paswan A , Vaddi S , Murthy J 
Published: October 2020

ABSTRACT
We present radio observations of the galaxy merger remnant Mrk 212 with the Karl G. Jansky Very Large Array (VLA) and the upgraded Giant Meter Radio Telescope (uGMRT). Mrk 212 has two previously known radio sources associated with the two optical nuclei, S1 and S2, with a projected separation of ∼6 kpc, making it a dual active galactic nuclei (AGN) candidate. Our new 15-GHz VLA observations reveal that S1 is a double radio source centred around the optical nucleus; its total extent is ∼750 pc its average 1.4−8.5 GHz spectral index is −0.81 ± 0.06. S1 therefore resembles a compact symmetric object. The 15-GHz VLA image identifies the radio source at S2 to be a compact core. Our radio observations therefore strongly support the presence of a dual AGN in Mrk 212. The optical emission line flux ratios obtained from the Himalayan Chandra Telescope (HCT) observations however, show that S1 and S2 both fall in the AGN + star formation (SF) region of the Baldwin, Philips and Terlevich (BPT) diagram. Weak AGN lying in the SF or AGN + SF intermediate regions in the BPT diagram have indeed been reported in the literature; our sources clearly fall in the same category. We find an extended radio structure in our newly reduced 8.5-GHz-VLA data, that is offset by ∼1 arcsec from the optical nucleus S2. New deep FUV and NUV observations with the Ultraviolet Imaging Telescope aboard AstroSat reveal SF knots around S2 as well as kpc-scale tidal tails; the SF knots around S2 coincide with the extended radio structure detected at 8.5 GHz. The radio spectral indices are consistent with SF. Any possible association with the AGN in S2 is unclear at this stage.
Customized optical mapping by CRISPR–Cas9 mediated DNA labeling with multiple sgRNAs
Authors: Abid Heba Z , Young Eleanor , McCaffrey Jennifer , Raseley Kaitlin , Varapula Dharma , Wang Hung-Yi , Piazza Danielle , Mell Joshua , Xiao Ming 
Published: October 2020

Abstract
Whole-genome mapping technologies have been developed as a complementary tool to provide scaffolds for genome assembly and structural variation analysis (1,2). We recently introduced a novel DNA labeling strategy based on a CRISPR–Cas9 genome editing system, which can target any 20bp sequences. The labeling strategy is specifically useful in targeting repetitive sequences, and sequences not accessible to other labeling methods. In this report, we present customized mapping strategies that extend the applications of CRISPR–Cas9 DNA labeling. We first design a CRISPR–Cas9 labeling strategy to interrogate and differentiate the single allele differences in NGG protospacer adjacent motifs (PAM sequence). Combined with sequence motif labeling, we can pinpoint the single-base differences in highly conserved sequences. In the second strategy, we design mapping patterns across a genome by selecting sets of specific single-guide RNAs (sgRNAs) for labeling multiple loci of a genomic region or a whole genome. By developing and optimizing a single tube synthesis of multiple sgRNAs, we demonstrate the utility of CRISPR–Cas9 mapping with 162 sgRNAs targeting the 2Mb Haemophilus influenzae chromosome. These CRISPR–Cas9 mapping approaches could be particularly useful for applications in defining long-distance haplotypes and pinpointing the breakpoints in large structural variants in complex genomes and microbial mixtures.
gcType: a high-quality type strain genome database for microbial phylogenetic and functional research
Authors: Shi Wenyu , Sun Qinglan , Fan Guomei , Hideaki Sugawara , Moriya Ohkuma , Itoh Takashi , Zhou Yuguang , Cai Man , Kim Song-Gun , Lee Jung-Sook , Sedlacek Ivo , Arahal David R , Lucena Teresa , Kawasaki Hiroko , Evtushenko Lyudmila , Weir Bevan S , Alexander Sarah , Dénes Dlauchy , Tanasupawat Somboon , Eurwilaichitr Lily , Ingsriswang Supawadee , Gomez-Gil Bruno , Hazbón Manzour H , Riojas Marco A , Suwannachart Chatrudee , Yao Su , Vandamme Peter , Peng Fang , Chen Zenghui , Liu Dongmei , Sun Xiuqiang , Zhang Xinjiao , Zhou Yuanchun , Meng Zhen , Wu Linhuan , Ma Juncai 
Published: October 2020

Abstract
Taxonomic and functional research of microorganisms has increasingly relied upon genome-based data and methods. As the depository of the Global Catalogue of Microorganisms (GCM) 10K prokaryotic type strain sequencing project, Global Catalogue of Type Strain (gcType) has published 1049 type strain genomes sequenced by the GCM 10K project which are preserved in global culture collections with a valid published status. Additionally, the information provided through gcType includes &gt;12 000 publicly available type strain genome sequences from GenBank incorporated using quality control criteria and standard data annotation pipelines to form a high-quality reference database. This database integrates type strain sequences with their phenotypic information to facilitate phenotypic and genotypic analyses. Multiple formats of cross-genome searches and interactive interfaces have allowed extensive exploration of the database's resources. In this study, we describe web-based data analysis pipelines for genomic analyses and genome-based taxonomy, which could serve as a one-stop platform for the identification of prokaryotic species. The number of type strain genomes that are published will continue to increase as the GCM 10K project increases its collaboration with culture collections worldwide. Data of this project is shared with the International Nucleotide Sequence Database Collaboration. Access to gcType is free at http://gctype.wdcm.org/.
Intergenerational Mobility in the Very Long Run: Florence 1427–2011
Authors: Barone Guglielmo , Mocetti Sauro 
Published: October 2020

Abstract
We examine intergenerational mobility in the very long run, across generations that are six centuries apart. We exploit a unique dataset containing detailed information at the individual level for all people living in the Italian city of Florence in 1427. These individuals have been associated, using their surnames, with their pseudo-descendants living in Florence in 2011. We find that long-run earnings elasticity is about 0.04; we also find an even stronger role for real wealth inheritance and evidence of persistence in belonging to certain elite occupations. Our results are confirmed when we account for the quality of the pseudo-links and when we address the potential selectivity bias behind the matching process. Finally, we frame our results within the existing evidence and argue that the quasi-immobility of preindustrial society and the existence of multigenerational effects might explain the long-lasting effects of ancestors’ socioeconomic status.
Building Longitudinal Relationships Into a Traditional Block Clerkship Model: A Mixed-Methods Study
Authors: Atalay Alev J. , Osman Nora Y. , Krupat Edward , Alexander Erik K. 
Published: October 2020

Purpose
The authors describe the implementation of the novel Longitudinal Clinical Experiences with Patients (LCEP) curriculum, designed to integrate continuity and longitudinal patient relationships into a traditional block clerkship (BC), and present a mixed-methods analysis evaluating program effectiveness to assess its feasibility, value, and impact.

Method
This was a mixed-methods study of 54 Harvard Medical School students who participated in the LCEP during their core clerkship (third) year during the 2013–2014 academic year. Fifty-two students responded to an electronic survey about the patients they followed during the LCEP. Forty-two students completed confidential live interviews. Unique groups of 13–15 students were interviewed at 3 times during the year to assess students’ perceptions of the LCEP over time. The data were analyzed using a content analysis framework.

Results
On average, students followed 3.3 LCEP patients over the clerkship year. Ninety-four percent (n = 49/52) of students were able to follow 2 or more patients longitudinally. Most students met their longitudinal patient in the inpatient setting (71%, n = 37/52). Subsequent encounters were most often in the ambulatory setting. Students described scheduling logistics as key to the success or failure of the program. Many students described the challenges of competing priorities between their BC responsibilities and longitudinal opportunities. Students found the LCEP deepened their understanding of the patient experience, the health care system, and disease progression. Over the course of an academic year, an increased proportion of students (60%) highlighted understanding the patient experience as a core value obtained through the LCEP.

Conclusions
The LCEP was feasible and proved successful in promoting longitudinal patient relationships within a traditional BC model. Prioritizing the depth of experience with a smaller number of patients may reduce the barriers described by students. The results suggest that such a hybrid program promotes patient-centeredness.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibodies at Delivery in Women, Partners, and Newborns
Authors: Egerup Pia , Fich Olsen Line , Christiansen Ann-Marie Hellerung , Westergaard David , Severinsen Elin Rosenbek , Hviid Kathrine Vauvert Römmelmayer , Kolte Astrid Marie , Boje Amalie Dyhrberg , Bertelsen Marie-Louise Mathilde Friis , Prætorius Lisbeth , Zedeler Anne , Nielsen Josefine Reinhardt , Bang Didi , Berntsen Sine , Ethelberg-Findsen Jeppe , Storm Ditte Marie , Bello-Rodríguez Judith , Ingham Andreas , Ollé-López Joaquim , Hoffmann Eva R. , Wilken-Jensen Charlotte , Krebs Lone , Jørgensen Finn Stener , Westh Henrik , Jørgensen Henrik Løvendahl , la Cour Freiesleben Nina , Nielsen Henriette Svarre 
Published: October 2020

OBJECTIVE:
To investigate the frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in parturient women, their partners, and their newborns and the association of such antibodies with obstetric and neonatal outcomes.

METHODS:
From April 4 to July 3, 2020, in a single university hospital in Denmark, all parturient women and their partners were invited to participate in the study, along with their newborns. Participating women and partners had a pharyngeal swab and a blood sample taken at admission; immediately after delivery, a blood sample was drawn from the umbilical cord. The swabs were analyzed for SARS-CoV-2 RNA by polymerase chain reaction, and the blood samples were analyzed for SARS-CoV-2 antibodies. Full medical history and obstetric and neonatal information were available.

RESULTS:
A total of 1,313 parturient women (72.5.% of all women admitted for delivery at the hospital in the study period), 1,188 partners, and 1,206 newborns participated in the study. The adjusted serologic prevalence was 2.6% in women and 3.5% in partners. Seventeen newborns had SARS-CoV-2 immunoglobulin G (IgG) antibodies, and none had immunoglobulin M antibodies. No associations between SARS-CoV-2 antibodies and obstetric or neonatal complications were found (eg, preterm birth, preeclampsia, cesarean delivery, Apgar score, low birth weight, umbilical arterial pH, need for continuous positive airway pressure, or neonatal admission), but statistical power to detect such differences was low. Full serologic data from 1,051 families showed an absolute risk of maternal infection of 39% if the partner had antibodies.

CONCLUSION:
We found no association between SARS-CoV-2 infection and obstetric or neonatal complications. Sixty-seven percent of newborns delivered by mothers with antibodies had SARS-CoV-2 IgG antibodies. A limitation of our study is that we lacked statistical power to detect small but potentially meaningful differences between those with and without evidence of infection.
INTERVORTEX VENOUS ANASTOMOSIS IN Pachychoroid-RELATED DISORDERS
Authors: Spaide Richard F. , Ledesma-Gil Gerardo , Gemmy Cheung Chui Ming 
Published: October 2020

Purpose:
To evaluate the choroidal vascular patterns of patients with pachychoroid-related diseases in eyes images with wide-field indocyanine green angiography.

Methods:
Retrospective study of wide-field indocyanine green angiographic images of patients with pachychoroid, peripapillary pachychoroid syndrome, central serous chorioretinopathy, and pachychoroid-associated neovascularization that were evaluated for anastomoses between vortex vein systems, which are ordinarily separated by a watershed zone.

Results:
There were 21 subjects with a mean age of 57.4 years and 15 were male. Among the 42 eyes evaluated, central serous chorioretinopathy was found in 24 eyes (57.1%), peripapillary pachychoroid syndrome in 5 (11.9%), pachychoroid associated neovascularization in 7 (16.7%), and pachychoroid in 6 (14.3%). Every eye showed anastomosis between the superonasal, superotemporal, and inferotemporal vortex vein systems. The inferonasal vortex vein system was less likely to demonstrate anastomosis except for peripapillary pachychoroid syndrome, which showed anastomosis in all eyes. The anastomotic connections were prominent in the central macula in the central serous chorioretinopathy and pachychoroid-associated neovascularization cases, and around the nerve in the peripapillary pachychoroid syndrome cases. Although the large choroidal veins were particularly prominent in the neovascular cases, the number was fewer in the macular region than in other pachychoroid-related diseases in this series. Compared with a control group of nine eyes, the inferotemporal–superotemporal–superonasal anastomotic connections were more common in the case group (P < 0.001) and inferonasal quadrant (P = 0.023 right eye; P = 0.01, left eye).

Conclusion:
Intervortex venous anastomosis is common in pachychoroid, central serous chorioretinopathy, peripapillary pachychoroid syndrome, and pachychoroid-associated neovascularization. This finding has important implications concerning pathogenesis and classification of disease.
Effect of interval between food intake and drug administration at fasting condition on the plasma concentrations of first-line anti-tuberculosis drugs in Chinese population
Authors: Wang Jun , Wang Jing , Du Yadong , Guo Ru , Han Xiqin , Wang Qingfeng , Pang Yu , Chu Naihui 
Published: October 2020

Abstract
We aimed to investigate the effect of interval between food intake and drug administration at fasting condition on the plasma concentrations of first-line anti- tuberculosis (TB) drugs in Chinese population. Newly diagnosed TB patients administered the anti-TB drugs under fasting conditions orally, and then had prepared breakfast at 30 minutes and 120 min after dosing, respectively. Blood sampling was also performed 120  minutes after dosing for the detection of C
max purpose. Overall, twenty-five participants were included in our analysis. The C
maxs of 30  minutes interval and 120  minutes interval were 21.8 ± 2.0 and 19.2 ± 2.0 μg/mL for rifampin, 1.6 ± 0.2 and 2.1 ± 0.2 μg/mL for isoniazid (INH), 1.5 ± 0.1and 1.5 ± 0.2 μg/mL for ethambutol (EMB), and 49.2 ± 3.7 and 41.5 ± 3.9 μg/mL for pyrazinamide, respectively. Statistical analysis revealed that there was no statistical difference between 2 groups. Additionally, 88.0% and 72.0% of the 25 participants at 2-hour interval group had peak concentrations less than the lower limit of the reference range for INH and EMB, respectively. The C
maxs of INH were 0.9 ± 0.4 μg/ml for rapid acetylator, which was significantly lower than those of intermediate (1.4 ± 1.0 μg/mL), and slow acetylator (2.5 ± 1.0 μg/mL), respectively (P < .01). In conclusion, our data demonstrate that early food intake at 30 minutes after drug administration had no significant influence on the plasma concentrations. In addition, a high proportion of patients receiving first-line anti-TB regimen fail to achieve the expected plasma drug ranges of INH and EMB (P > .05).
Accuracy of tumor size measurement on shear wave elastography (SWE)
Authors: Ko Kyung Hee , Jung Hae Kyoung , Park Ah Young , Koh Ji Eun , Jang Hyunkyung , Kim Yunju 
Published: October 2020

Abstract
The aim of this study is to investigate the accuracy of tumor size assessment by shear wave elastography (SWE) in invasive breast cancer and also evaluated histopathologic factors influencing the accuracy.
A total of 102 lesions of 102 women with breast cancers of which the size was 3 cm or smaller were included and retrospectively analyzed. Tumor size on B-mode ultrasound (US) and SWE were recorded and compared with the pathologic tumor size. If tumor size measurements compared to pathological size were within ±3 mm, they were considered as accurate. The relationship between the accuracy and histopathologic characteristics were evaluated.
The mean pathologic tumor size was 16.60 ± 6.12 mm. Tumor sizes on SWE were significantly different from pathologic sizes (18.00 ± 6.71 mm, P < 0.001). The accuracy of SWE (69.6%) was lower than that by B-mode US (74.5%). There was more size overestimation than underestimation (23.5% vs 6.9%) using SWE. Conversely, there was more size underestimation than overestimation (18.6% vs 6.9%) using B-mode US. The accuracy of SWE was associated with ER positivity (P = .004), PR positivity (P = .02), molecular subtype (P = .02), and histologic grade (P = .03). In the multivariate analysis, ER positivity (P = .002) and molecular subtype (P = .027) significantly influenced the accuracy of tumor size measurement by SWE.
In conclusion, the accuracy of the tumor size measured with SWE was lower than that measured with B-mode US and SWE tends to overestimate the size. ER positivity and molecular subtype are significantly associated with the accuracy of SWE in tumor size assessment.
FOLFIRINOX for Recurrent Pancreatic Cancer After Pancreatic Resection
Authors: Morinaga Soichiro , Takita Morihito , Yoshizawa Atsuko , Kamei Keiko , Nakamori Shoji , Ishihara Shin , Kuramochi Hidekazu , Yokoyama Yukihiro , Uchiyama Takashi , Murohisa Gou , Ishigaki Marina , Todaka Akiko , Fukutomi Akira 
Published: October 2020

Objectives
The multidrug regimen with fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) is widely used for recurrent pancreatic cancer after pancreatic resection. However, there are concerns about severe toxicities and poor tolerability of FOLFIRINOX in these patients because some suffer from surgery-associated malnutrition, weight loss, and diabetes mellitus. We evaluated the toxicity and tolerability of FOLFIRINOX in these patients.

Methods
This study was conducted as a secondary analysis of the Japan Adjuvant Study Group of Pancreatic Cancer 06 study, which was a multicenter observational study of FOLFIRINOX for pancreatic cancer in Japan. The toxicity and tolerability of FOLFIRINOX in recurrent disease correlated with those of both the locally advanced and the metastatic disease group.

Results
The major grades 3 and 4 toxicities observed in the recurrent and locally advanced or metastatic disease groups were neutropenia (68% vs 63%), febrile neutropenia (4% vs 15%, P = 0.007), thrombocytopenia (4% vs 3%), diarrhea (4% vs 8%), and sensory neuropathy (0% vs 2%). The dose modification and relative dose intensity did not differ markedly between the groups.

Conclusions
The toxicity and tolerability of FOLFIRINOX for recurrence after pancreatic resection were similar to those for locally advanced or metastatic disease with appropriate patient selection and dose modifications.
Treatment Strategies for the Optimal Management of Locally Advanced Pancreatic Adenocarcinoma With Curative Intent
Authors: Attard Joseph A. , Farrugia Alexia , Pathanki Adithya , Roberts Keith J. , Dasari Bobby , Isaac John , Ma Yuk Ting , Chatzizacharias Nikolaos A. 
Published: October 2020

Abstract
Historically, locally advanced pancreatic adenocarcinoma (LAPDAC) was considered a palliative condition. Advances in treatment have resulted in studies reporting survival after neoadjuvant treatment and surgery similar to earlier disease stages. However, there is no consensus on optimal LAPDAC management. Our aim was a systematic review of published evidence on LAPDAC treatment strategies with curative intent. Twenty-eight studies defining LAPDAC as per established criteria and reporting outcomes after neoadjuvant treatment with a view to resection were included. Primary outcomes were resection rate and proportion of curative resections. Secondary outcomes were postoperative mortality, progression-free survival, and overall survival. Neoadjuvant treatment varied significantly, most common being the combination of folinic acid, fluorouracil, irontecan, and oxaliplatin. Median percentage of patients proceeding to surgery after completion of neoadjuvant pathway was 33.5%. Median resection rate was 25%. Median R0 resection was 80% of resected patients. These outcomes ranged 0% to 100% across studies. Ninety-day postoperative mortality ranged from 0% to 5%. Median progression-free and overall survival for resected patients were 12.9 and 30 months, respectively, versus 13.2 months overall survival for unresected patients. In conclusion, although there is wide variability in reported LAPDAC resection rates post–neoadjuvant chemotherapy, retrospective data suggest that neoadjuvant treatment followed by surgery results in improved survival.
Low-Molecular–Weight Heparin Combined With Insulin Versus Insulin Alone in the Treatment of Hypertriglyceridemic Pancreatitis (LIHTGP Trial)
Authors: Yu Bingjun , He Wenhua , He Cong , Li Nianshuang , Li JiaRong , Zhu Yin , Chen Youxiang , Lu Nonghua 
Published: October 2020

Objective
Currently, insulin and/or heparin/low-molecular–weight heparin (LMWH) serve as an early lipid-lowering treatment for hypertriglyceridemic pancreatitis (HTGP). However, whether the clinical prognosis of combining LMWH with insulin is superior to using insulin alone remains unknown. This trial will compare the clinical outcomes of LMWH with insulin and an insulin regimen for emergency lipid-lowering treatment in HTGP patients.

Methods
In total, 476 eligible participants will be recruited from 18 hospitals throughout China. Participants in the LMWH group will receive LMWH combined with insulin, whereas insulin alone will be administered to those in the insulin group. The patients will be followed up at 3 and 6 months after discharge. Adverse reactions will be evaluated by the safety monitoring committee. Safety outcomes and adverse events will also be recorded.

Results
The study is registered in the Chinese Clinical Trial Registry (No: ChiCTR1900023640). Recruitment will begin in August 2019 and will be completed in December 2021 (http://www.chictr.org.cn/index.aspx). No data are available now.

Conclusions
The trial will investigate the efficacy of using LMWH combined with insulin as an emergency lipid-lowering treatment in reducing new organ failure, mortality, hospital stays, and expenses compared using with insulin alone for patients with HTGP.