bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic and rejuvenating potential of Guduchi Taila in the purview of rheumatoid arthritis: A review
Authors: Sharma Pankaj , Shetty Suhas Kumar 
Published: December 2024

Abstract
Rheumatoid arthritis (RA) is an immune-mediated chronic inflammatory disease affecting multiple joints which is characterized by synovial hyperplasia, autoantibody production, cartilage, and bone degeneration. This paper reviews the Ayurvedic management of RA through the purview of Vataraktam (NAMC Code ED-8), a condition described in Ayurveda that parallels the symptoms and pathogenesis of RA focusing on Guduchi Taila. The data was gathered from authoritative Ayurvedic texts and contemporary biomedical sources to explore the efficacy of Guduchi Taila, an Ayurvedic oleaginous formulation containing Guduchi (Tinospora cordifolia [Willd.] Miers), Tila Taila (Sesamum indicum L.), and Goksheera (cow milk). Guduchi Taila possesses significant therapeutic potential in managing RA by alleviating inflammation, modulating immune responses, and providing rejuvenation (Rasayana action). Guduchi’s active components, such as flavonoids and alkaloids, exhibit anti-inflammatory and immunomodulatory effects, particularly beneficial in RA. Tila Taila’s unsaturated fatty acids and lignans contribute to its anti-inflammatory properties. Goksheera offers immunostimulatory and anti-inflammatory benefits, particularly through its unique protein, milk fat globule-EGF factor 8. This formulation’s combined effects suggest a multifaceted RA treatment approach, addressing symptom management and arresting disease progression. This review concludes that Guduchi Taila, through its Tridosha balancing properties and rejuvenating actions (Rasayana), presents a promising option for RA management utilizing the principles of Vataraktam, meriting further clinical investigation to validate its efficacy.
Unveiling the mechanisms of Rasayana therapy: Spotlight on unique contribution of Gokshura as Rasayana and Vajikarana Dravya in various classical texts
Authors: Payal Purohit , Thummar Pratik , Sreebala G. , Patel Bhupesh R. 
Published: December 2024

Abstract
The medicinal plant Gokshura (Tribulus terrestris L.) is utilized as a medicine as well as Vajikarana (aphrodisiac) and Rasayana Dravya (rejuvenative) in Ayurvedic literature. An attempt has been made to comprehensively review and document the Rasayana and Vajikarana properties of Gokshura, enlisted in different contexts across Ayurvedic texts and contemporary information from articles from peer-reviewed journals. It was found that 58 Rasayana and 54 Vajikarana formulations including Gokshura as a single ingredient in different dosage forms are mentioned in Ayurveda classics. Additionally, studies on Gokshura have shown that it has important chemical constituents which contribute to immunomodulatory, aphrodisiac, antioxidant, antidepressant, hepatoprotective, nephroprotective, and cardiotonic properties. The current article offers a realistic assessment of Gokshura (Tribulus terrestris L.) based on the formulations that are need in a number of rare Ayurvedic texts with its supporting evidences from scientific articles.
A comprehensive review of the altmetrics of top 50 scholarly publications on Ayurveda Rasayana
Authors: Singh Shyam Babu , Mansoria Poornima , Sisodia Brijesh Singh , Kumar Vijay , Kumar Arvind 
Published: December 2024

Abstract
This study presents a comprehensive analysis of the top 50 publications on Rasayana, focusing on their Altmetric Attention Scores (AAS) as a measure of the digital and societal impact. A search on Dimension AI identified 1386 publications, from which the top 50 publications based on AAS were selected, spanning from 1999 to 2023. Predominantly from India, these publications were distributed across 32 journals, with the leading one being “Journal of Ethnopharmacology”. The research covered diverse topics, including clinical trials, molecular studies, and reviews, highlighting Rasayanas’ therapeutic properties in anti-aging, mental health, and immune modulation. Ashwagandha was mentioned prominently, with studies emphasizing its efficacy in insomnia, anxiety, and physical performance. High AAS values correlated with substantial number of citations, indicating widespread academic and public interest. This analysis underscores the increasing prominence of Rasayanas in medical research and their potential in promoting health and wellness.
Therapeutic potential of Glycyrrhiza glabra L. in managing oxidative stress-induced disorders
Authors: Pandey Dhritika , Dubey Vishwesh , Singh Anupriya 
Published: December 2024

Abstract
Oxidative stress is a critical factor in the pathogenesis of various diseases, including cancers, neurodegenerative disorders, and inflammatory conditions. Glycyrrhiza glabra L., commonly known as licorice, has been utilized in traditional medicine systems for its therapeutic benefits, particularly its rejuvenating properties. This review provides a detailed examination of the ethnopharmacological applications, global distribution, and phytochemical composition of G. glabra. Furthermore, the key bioactive molecules of G. glabra, such as glycyrrhizin, glycyrrhizinic acid, and isoliquiritin, are highlighted for their roles in counteracting oxidative stress. These phytomolecules have been shown to exert significant effects through mechanisms such as modulation of antioxidant enzyme activities and inhibition of free radical production. Comprehensive literature searches were performed across major scientific databases, including PubMed, Web of Science, PMC, Google Scholar, Springer, ScienceDirect, and Research Gate, to synthesize information on G. glabra. The review explores how these phytomolecules contribute to the mitigation of oxidative stress-related disorders, including cancer, neurodegenerative diseases, and inflammatory conditions. By synthesizing data from experimental studies, this review underscores the therapeutic potential of G. glabra in managing oxidative stress-induced conditions. It also identifies gaps in the current understanding of its molecular mechanisms and suggests the need for further research, to enhance its application in therapeutic settings. Future studies shall focus on elucidating the synergistic effects of bioactive compounds of G. glabra and their integration into clinical practice and integrative research to fully exploit its medicinal benefits.
Pharmacological insights and therapeutic potential of Amalaki Rasayana: A comprehensive review
Authors: Ashraf Abdul Hakeem Sayed , Sarkar Kingsuk , Sobhana Shreelakshmi Radhakrishnan , Chalil Lijima , Sen Animesh , Mitra Achintya 
Published: December 2024

Abstract

Amalaki Rasayana (AR), derived from the fruits of Phyllanthus emblica, is a traditional Ayurvedic formulation renowned for its broad spectrum of pharmacological properties. This review critically examines recent research on AR, highlighting its potential therapeutic applications in modern medicine. The necessity for this review stems from the growing interest in integrating traditional Ayurvedic formulations with contemporary healthcare practices, particularly for managing chronic and age-related conditions. To gather relevant data, a comprehensive literature search was conducted across multiple databases, focusing on studies published to date. The inclusion criteria centered on experimental and clinical studies that evaluated the antioxidant, anti-aging, cardioprotective, antihypertensive, anticancer, antidiabetic, and immunomodulatory effects of AR. The review findings suggest that AR may significantly reduce blood glucose levels, enhance immune function, protect cardiovascular health by modulating blood lipid profiles, improve cardiac function, and promote cognitive function. Its potent antioxidant properties are also highlighted, which are crucial in mitigating oxidative stress and providing cellular protection. While AR shows considerable promise as a therapeutic agent, particularly in managing chronic diseases and age-related conditions, additional research and clinical trials are required to thoroughly understand its mechanisms of action and enhance its therapeutic potential. By bridging the gap between traditional Ayurvedic knowledge and contemporary scientific inquiry, this review underscores the potential of AR to contribute to novel treatment strategies and enhance existing therapeutic approaches.
Effect of Vitamin B12 supplementation in late-life depression: A randomized controlled trial
Authors: Misal Pooja , Srivastava Shrikant , Sonal Akanksha , Agarwal Vivek , Ali Wahid 
Published: December 2024

ABSTRACT

Background:
Late-life depression (LLD) has a poor response to the first-line standard antidepressant medications. This study aims to determine the effect of Vitamin B12 supplementation as an augmentation to the antidepressant medications as the first-line therapy in LLD to accelerate and/or maximize the response and remission.

Materials and Methods:
It was a prospective randomized controlled trial of 4 weeks; 62 depressed older adults (age >50 years) with low but not below the normal range of serum Vitamin B12 levels (>187 but <350 pg/ml) were randomized to receive either Vitamin B12 (7500 μg intramuscular injection over 15 days in 5 divided dosages) and an antidepressant (case) or only an antidepressant (control). Structured assessment of depressive disorder was carried out on days 0, 14, and 28, using hamilton rating scale for depression (HAM-D) and Geriatric Depression Scale Hindi version (GDS-H). Hindi Mental Status Examination was used at baseline to exclude primary cognitive impairment.

Results:
There was a significant decline in the depression scores in the Vitamin B12 supplementation group on both the HAM-D (P = 0.01, partial η2 = 0.113) and GDS (P = 0.01, partial η2 = 0.102) between days 0 and 28, with statistically more remitted subjects in the supplementation group (78% vs. 47%, P = 0.001).

Conclusion:
Vitamin B12 supplementation to standard antidepressant significantly improved the response and remission rates in subjects with low-normal serum Vitamin B12 levels.
Impact of Obesity on Balance and Musculoskeletal Flexibility in Primary School Children
Authors: Sharma Ankita , Dhiman Sapna , Jha Niharika , Kundra Sanya 
Published: December 2024

Abstract

Background:
Childhood obesity is a growing global health problem affecting children worldwide due to an increasingly sedentary lifestyle as children often prefer screen-based indoor activities over physical exercise. In addition, factors such as unhealthy dietary habits, and sleep deprivation, also contribute to weight gain and additional health complications. This study assessed physical impairments associated with obesity in primary school children, specifically flexibility and balance.

Materials and Methods:
A sample of 128 children aged 6–11 years were selected using non-probability convenience sampling. Height, weight, and body mass index (BMI) were measured, and participants were divided into two groups: normal-weight (64 participants) and obese (64 participants). Balance was assessed using the pediatric balance scale (PBS) and the pediatric reach test (PRT). Musculoskeletal flexibility was evaluated by testing calf flexibility using the weight-bearing lunge test (WBLT), hamstring flexibility with the V sit and reach test (VSRT), and the active knee extension test.

Results:
Significant differences were found between the two groups in BMI, PBS, PRT, WBLT (right and left leg), VSRT, and active knee extension test (right and left leg), with P < 0.05. Obesity significantly impacts balance and musculoskeletal flexibility in primary school children.

Conclusion:
This study concludes that children with obesity exhibit impaired balance and reduced calf and hamstring flexibility.
Menstrual Hygiene in Adolescent Girls: Findings from a Survey in the Urban Government Schools, Visakhapatnam, India
Authors: Valluri Vandana , Attili Saivaishnavi , Chamarty Phani Krishna , Prabhanjana Tejaswi , Santosh Murali 
Published: December 2024

Abstract

Background:
Menstrual health management is influenced by social and cultural factors, as well as knowledge gaps. Poor hygiene practices can negatively affect academic performance and health outcomes.

Materials and Methods:
A survey was conducted among 1350 adolescent girls in urban public schools in Visakhapatnam, India.

Results:
The survey found positive progress in menstrual hygiene management, but some challenges remain. While 81.7% of girls reported having enough sanitary materials, only 66.1% had access to soap and water for hygiene purposes. Over half (52.4%) of the students struggled with menstrual pain, and 37.6% reported difficulty participating in school activities during their periods. Notably, 93.5% of the respondents were unaware of the human papillomavirus vaccine and its ability to prevent cervical cancer.

Conclusions:
This survey highlights progress in menstrual hygiene management in urban schools, and also identifies persistent knowledge gaps and access issues.
Cosmotécnicas y tecnodiversidad
Authors:   Universidad de Buenos Aires, Amore Lautaro 
Published: December 2024

En este artículo nos proponemos relacionar el concepto de cosmotécnica, de Yuk Hui, con la consideración hegemónica de la tecnociencia, e introducirnos en narrativas alternativas sobre el desarrollo tecnológico. Buscamos líneas discursivas y metodológicas que se salgan del relato de un desarrollo tecnocientífico sincrónico y universal. Sobre todo, queremos presentar alternativas al colapso ecológico que difieran del deceleracionismo y de la falacia transhumanista. La narrativa de una tecnociencia sincrónica occidental sería premodernidad- modernidad- posmodernidad-apocalipsis, siendo este último término el de mayor relevancia. En los ensayos de Fragmentar el futuro, Hui propone un repaso por la filosofía sobre la técnica en occidente para mostrar su especificidad y desuniversalizarla.
A SAÚDE MENTAL NA POLÍCIA MILITAR DO PARANÁ: O IMPACTO DO ESTRESSE E DA VIOLÊNCIA NA REALIDADE POLICIAL
Authors: Oliveira Cesar Augusto de , Prado Hellen Kamylla do 
Published: December 2024

O objetivo deste artigo foi o de analisar as consequências do estresse e da violência na saúde mental do policial militar no Estado do Paraná. A metodologia utilizada para a elaboração deste artigo foi a da revisão descritiva de literatura de caráter exploratório, a partir de consultas de materiais diversos já publicados. Pode-se compreender que as principais motivações inerentes à saúde mental dos policiais, especificamente aos militares, se relacionam diretamente com a desumanização do trabalho destes profissionais, conduta esta decorrente da própria sociedade e do Estado que tende a ter uma percepção negativa de seu trabalho, concebendo-o como mão opressora do Estado; e pelo não reconhecimento das necessidades do policial, respectivamente, preterindo-os não somente de estrutura material, mais principalmente de desenvolver programas de atenção que o perceba como um ser humano, que não o tenha como um problema diante de seus problemas e adversidades de saúde. A consequência desta realidade são a etiologia dos transtornos mentais, como depressão, ansiedade e, em casos mais severos, o suicídio. Chama a atenção para a necessidade de desenvolvimento de políticas destinadas a prevenir e tratar policiais em risco, é necessário que o Estado enxergue tal condição e passe a atuar com uma ação mais humanizada e que externamente atue no sentido de valorizar este profissional junto à sociedade, dando-lhes respaldo quando atacado, aviltado e criminalizado ante circunstância dentro dos ditâmes legais.
Effectiveness of enhanced care for treatment of acute or persistent diarrhea in malnourished children aged 0 months to 10 years: a systematic review
Authors: Alam Ridwa , Vadsaria Khadija , Khan Ahmad , Jiwani Uswa , Ishaq Aqsa , Minaz Anmol , Sharif Ashraf , Bin Nisar Yasir , Das Jai K , Soofi Sajid , Ariff Shabina 
Published: December 2024

Background Diarrhea poses a significant public health challenge, particularly affecting children under five. The link between malnutrition and diarrhea is well established, with diarrhea being a primary cause of malnutrition in young children and malnutrition exacerbating the severity of diarrhea. While the World Health Organization (WHO) recommends a comprehensive approach to both diarrhea and malnutrition management, including oral rehydration, continuous feeding, zinc supplementation, and antibiotics for specific strains, it does not adequately address the complex needs of malnourished children with diarrhea who may benefit from enhanced care in the form of follow-up and monitoring beyond initial treatment. We aimed to assess the effectiveness of enhanced care—defined as hospitalization, close clinical monitoring, or longer follow-up after completion of treatment—compared to WHO-defined standard care in improving clinical outcomes among malnourished children aged 0 to 10 years experiencing acute or persistent diarrhea. Methods A systematic search across PubMed, CINAHL, Cochrane Library, and Scopus identified 1494 records from 2000 onwards. Observational studies and randomized trials assessing the effectiveness of enhanced care for malnutrition and diarrhea in children in community- or hospital-based settings were considered. This review was commissioned by WHO to revise their guidelines on childhood diarrhea management. Results Of the 1494 records, 1417 studies were excluded during the title and abstract screening. The remaining 77 studies underwent full-text screening, but all were excluded for not meeting the eligibility criteria. However, three studies assessing alternative care were presented, but none focused on enhanced care. Consequently, no synthesis or risk of bias was conducted. Conclusions Our review did not identify studies meeting the definition of enhanced care for dehydrating diarrhea in malnourished children, underscoring the need for further research. Future reviews focusing on additional risk factors, including HIV and age, are also essential to establish conclusive evidence regarding the effectiveness of enhanced care in managing children with diarrhea.
Área de educación artística en la escuela de educación especial. Abordaje neuroeducativo en niños y niñas con discapacidad intelectual
Authors: Tillería Pérez Galvarino Daniel 
Published: December 2024

La investigación aborda cómo se enseña y cómo se aprende en Educación Artística en escuelas especiales de Rosario, Argentina.
Elaboración de snack con harina de machica y frutos secos para combatir la desnutrición en Unidad Educativa Monte Sinaí Guayaquil-Ecuador
Authors: Gordillo Alvarado Mercedes , Viteri Carrillo Tatiana Priscila 
Published: December 2024

El presente trabajo de titulación tiene como objetivo elaborar un snack con harina de machica y frutos secos para combatir la desnutrición en zona vulnerable de Guayaquil-Monte Sinaí, siendo el principal problema el desconocimiento en dar la primera colación nutritiva, se incluyó la machica como ingrediente principal en elaboración de snack, estas fueron distribuidas en la Unidad Educativa Monte Sinaí Guayaquil. Su enfoque metodológico se basó en el método cuantitativo, asimismo se direcciono bajo el método experimental donde se efectuaron pruebas de estudio en los productos seleccionados como son: harina de machica y frutos secos (almendra y nuez). La población de estudio estuvo compuesta por 95 niños que parten desde 5-10 años de edad, pertenecientes a la Unidad Educativa ya expuesta. Como resultado se obtuvo el peso promedio general inicial de 17,2 ± 4,0323. Poniendo en práctica la propuesta de este trabajo (Snack de harina machica y frutos secos-dieta balanceada) se tomaron nuevas medidas en el peso- talla actual, donde los datos exponen que peso promedio ganado corresponde a 0,52173913 ± 0,338626551. Así también en lo que corresponde a la talla se expone que la talla promedio inicial es de 121,6195± 11,040; en consideración con la talla promedio del primer mes de prueba en cuanto a la propuesta (galleta de harina machica y frutos secos-dieta balanceada según los requerimientos) se evidencio que es de 122,54 ± 11,24. Como resultado se pudo concluir que la dieta balanceada y la galleta nutritiva incidieron de manera positiva en la nutrición de los niños.
Estudio del Cauje (Pouteria caimito) como alimento gastronómico nutricional en escolares de 6 a 12 años de la escuela “León de Febres Cordero” en la Ciudad de Guayaquil
Authors: Gordillo Alvarado Mercedes María , Robles Vélez Tania Paola 
Published: December 2024

El presente trabajo es una recopilación de información acerca del Pouteria caimito, y su posterior introducción en la dieta diaria de escolares entre 6 a 12 años de una escuela fiscal ubicada en la ciudad de Guayaquil, en nuestra ciudad existen altos indicadores de desnutrición u obesidad cuyo origen empieza por la mala alimentación el cual se genera por un consumo excesivo de grasas y carbohidratos principalmente en niños de 9 a 11 años de edad, mientras que la desnutrición se da especialmente por la falta de ingesta de micronutrientes y es más común en niños menores de 5 años. Ecuador es país con una diversidad de frutas con un alto potencial nutritivo el cual lastimosamente resulta desconocido para muchas familias ecuatorianas, entre ellas tenemos el cauje (Pouteria caimito) que contiene una gran variedad de vitaminas que aportan mucho al sistema inmunológico además de una alta presencia de Calcio, Fósforo y Lisina el cual es uno de los 10 aminoácidos esenciales para el ser humano, además de que su consumo estimula la hormona del crecimiento y el desarrollo mental, teniendo en cuenta todos los beneficios nutricionales que contiene la fruta realizo un estudio investigativo que incluye la realización de propuestas gastronómicas para ser incluidas en la dieta escolar diaria de niños de la Escuela “León de Febres Cordero” realizando un monitoreo periódico acerca de su evolución en talla y peso. Durante de 2 meses, se adjuntan los registros se puede evidenciar el cambio que se obtuvo en los infantes.
Estudio de factibilidad para la elaboración de nuggets de carne de camarón (litopenaeus vannamei) enriquecidos con quinua (chenopodium quinua) como una alternativa nutritiva para la población guayaquileña
Authors: Ochoa Palma Marcia Idilma , Muñoz Meza Simón Alejandro 
Published: December 2024

En el presente trabajo de investigación se realiza un estudio para la elaboración de Nuggets de camarón (Litopenaeus vannamei) enriquecido con quinua (Chenopodium Quinua) a partir de la carne del camarón como alternativa real gastronómica para la ciudad de Guayaquil y a su vez ampliar la oferta alimenticia en el país, El camarón es un producto simbólico para el país, de la cual se obtienen deliciosos platos ecuatorianos que son típicos en ciudades y pueblos del país. Se investiga y se observa los datos e historia sobre la actividad camaronera en el país, comenzando con las generalidades del camarón, su producción a nivel nacional, el ciclo de vida del camarón y todo lo que envuelve a la producción del camarón y de la quinua INIAP Thunkahuán. A su vez se analiza el método de la investigación a utilizar en el presente trabajo, se busca encontrar el método idóneo para hallar la manera de elaborar el Nuggets y a su vez observar cual es el Nuggets que la población guayaquileña le gustaría adquirir y consumir. La idea principal de la elaboración del Nuggets es otorgar a la ciudadanía guayaquileña una alternativa nutritiva a base de este marisco con el fin de dar una opción saludable a la población guayaquileña. Con lo cual a su vez también se busca reforzar la economía y consumo de estos productos autóctonos, se realizan experimentaciones para observar preferencia del producto con lo cual se observó el agrado por parte de los jueces lo demuestra que existe una posibilidad técnica y económica para la elaboración del Nuggets de camarón enriquecido con quinua.