bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why the COVID-19 response needs International Relations
Authors: Davies Sara E , Wenham Clare 
Published: September 2020

Abstract
The COVID-19 pandemic affects all countries, but how governments respond is dictated by politics. Amid this, the World Health Organization (WHO) has tried to coordinate advice to states and offer ongoing management of the outbreak. Given the political drivers of COVID-19, we argue this is an important moment to advance International Relations knowledge as a necessary and distinctive method for inclusion in the WHO repertoire of knowledge inputs for epidemic control. Historical efforts to assert technical expertise over politics is redundant and outdated: the WHO has always been politicized by member states. We suggest WHO needs to embrace the politics and engage foreign policy and diplomatic expertise. We suggest practical examples of the entry points where International Relations methods can inform public health decision-making and technical policy coordination. We write this as a primer for those working in response to COVID-19 in WHO, multilateral organizations, donor financing departments, governments and international non-governmental organizations, to embrace political analysis rather than shy away from it. Coordinated political cooperation is vital to overcome COVID-19.
Oral health promotion apps: an assessment of message and behaviour change potential
Authors: KACZMARCZYK Katherine H , GRAY-BURROWS Kara A , VINALL-COLLIER Karen , DAY Peter F 
Published: September 2020

Abstract

Background
Oral health worldwide needs improving: untreated dental caries is the most common health condition affecting people globally. Mobile applications (apps) have potential to provide preventative oral health interventions. This study aimed to investigate the quality of available oral health promotion apps, assessing information provided and the barriers to oral health addressed using psychological frameworks.

Methods
A content assessment of oral health promotion apps targeted at adults in the UK iTunes store was conducted. The quality of 22 apps was assessed against 3 objective indices derived from the Delivering Better Oral Health toolkit, Theoretical Domains Framework and Behaviour Change Technique Taxonomy. Index scores were calculated and descriptive analyses were completed.

Results
On average, four Delivering Better Oral Health messages, seven Theoretical Domains Framework components and eight Behaviour Change Technique Taxonomy components were addressed per app. The most common components were: ‘take at least two minutes to brush’ for the Delivering Better Oral Health index, ‘goals’ and ‘intentions’ for the Theoretical Domains Framework index and ‘goal setting (behaviour)’ for the Behaviour Change Technique Taxonomy index.

Conclusion
The quality of information available in oral health apps requires improvement with the majority addressing only a few barriers to oral health. Currently, there is no recognized scale for evaluating oral health apps: this study provides a suggested method for future app evaluation. There is opportunity for a new app to be created based on health behaviour change theory which includes all the Delivering Better Oral Health messages.
Pragmatic Mobilities and Uncertain Lives: Agency and the Everyday Mobility of South Sudanese Refugees in Uganda
Authors: O’Byrne Ryan Joseph , Ogeno Charles 
Published: September 2020

AbstractThis article investigates the pragmatic, everyday journeys of South Sudanese refugees in northern Uganda’s Palabek Refugee Settlement through a mobilities-focused analytical lens. Despite the repatriation of vast numbers of refugees, little is known about the diversity of refugees’ later movements. Recognition of this complexity is important. Although many of our South Sudanese interlocutors take part in multiple interconnected movements both within and across borders, these are frequently irregular and unpredictable. We define these refugees’ ‘pragmatic mobilities’ as ‘the experience and practice of multiple, distinct yet interconnected mobilities, despite trying times and unknowable circumstances’, thereby attending to the fractured (dis)junctures between these journeys as well as to their full temporal and geographical scope. By setting the practice and experience of South Sudanese refugees’ ongoing and everyday mobilities within wider personal and regional historical perspectives, we argue that the diversities within these refugees’ ‘pragmatic mobility’ practices demonstrate powerful manifestations of agency. We consequently understand these movements to be essential elements within everyday—yet crucial—practices to gain and maintain personal and collective control in otherwise uncertain contexts.
V1460 Her: a fast spinning white dwarf accreting from an evolved donor star
Authors: Ashley R P , Marsh T R , Breedt E , Gänsicke B T , Pala A F , Toloza O , Chote P , Thorstensen John R , Burleigh M R 
Published: September 2020

ABSTRACT
We present time-resolved optical and ultraviolet (UV) spectroscopy and photometry of V1460 Her, an eclipsing cataclysmic variable with a 4.99-h orbital period and an overluminous K5-type donor star. The optical spectra show emission lines from an accretion disc along with absorption lines from the donor. We use these to measure radial velocities, which, together with constraints upon the orbital inclination from photometry, imply masses of $M_1=0.869\pm 0.006\, \mathrm{M}_\odot$ and $M_2=0.295\pm 0.004\, \mathrm{M}_\odot$ for the white dwarf and the donor. The radius of the donor, $R_2=0.43\pm 0.002\, \mathrm{\it R}_\odot$, is ≈50 per cent larger than expected given its mass, while its spectral type is much earlier than the M3.5 type that would be expected from a main-sequence star with a similar mass. Hubble Space Telescope (HST) spectra show strong N v 1240-Å emission but no C iv 1550-Å emission, evidence for CNO-processed material. The donor is therefore a bloated, overluminous remnant of a thermal time-scale stage of high mass transfer and has yet to reestablish thermal equilibrium. Remarkably, the HST UV data also show a strong 30 per cent peak-to-peak, $38.9\,$s pulsation that we explain as being due to the spin of the white dwarf, potentially putting V1460 Her in a similar category to the propeller system AE Aqr in terms of its spin frequency and evolutionary path. AE Aqr also features a post-thermal time-scale mass donor, and V1460 Her may therefore be its weak magnetic field analogue since the accretion disc is still present, with the white dwarf spin-up a result of a recent high accretion rate.
Three-component modelling of C-rich AGB star winds – V. Effects of frequency-dependent radiative transfer including drift★
Authors: Sandin Christer , Mattsson Lars 
Published: September 2020

ABSTRACT
Stellar winds of cool carbon stars enrich the interstellar medium with significant amounts of carbon and dust. We present a study of the influence of two-fluid flow on winds where we add descriptions of frequency-dependent radiative transfer (RT). Our radiation hydrodynamic models in addition include stellar pulsations, grain growth and ablation, gas-to-dust drift using one mean grain size, dust extinction based on both the small particle limit (SPL) and Mie scattering, and an accurate numerical scheme. We calculate models at high spatial resolution using 1024 gridpoints and solar metallicities at 319 frequencies, and we discern effects of drift by comparing drift models to non-drift models. Our results show differences of up to 1000 per cent in comparison to extant results. Mass-loss rates and wind velocities of drift models are typically, but not always, lower than in non-drift models. Differences are larger when Mie scattering is used instead of the SPL. Amongst other properties, the mass-loss rates of the gas and dust, dust-to-gas density ratio, and wind velocity show an exponential dependence on the dust-to-gas speed ratio. Yields of dust in the least massive winds increase by a factor 4 when drift is used. We find drift velocities in the range $10\!-\!67\, \mbox{km}\, \mbox{s}^{-1}$, which is drastically higher than in our earlier works that use grey RT. It is necessary to include an estimate of drift velocities to reproduce high yields of dust and low wind velocities.
Dietary and lifestyle factors effect erythrocytePIG-Amutant frequency in humans
Authors: Lawrence Rachel , Haboubi Hasan , Williams Lisa , Doak Shareen , Jenkins Gareth 
Published: September 2020

AbstractIt is well understood that poor diet and lifestyle choices can increase the risk of cancer. It is also well documented that cancer is a disease of DNA mutations, with mutations in key genes driving carcinogenesis. Measuring these mutations in a minimally invasive way may be informative as to which exposures are harmful and thus allow us to introduce primary preventative measures, in a bid to reduce cancer incidences. Here, we have measured mutations in the phosphatidylinositol glycan class A (PIG-A) gene in erythrocytes from healthy volunteers (n = 156) and from non-cancer patients attending the local endoscopy department (n = 144). The X-linked PIG-A gene encodes an enzyme involved in glycosylphosphatidylinositol (GPI) anchor synthesis. A silencing mutation in which leads to the absence of GPI anchors on the extracellular surface which can be rapidly assessed using flow cytometry. The background level of PIG-A mutant erythrocytes was 2.95 (95% CI: 2.59–3.67) mutant cells (10−6). Older age increased mutant cell frequency (P &lt; 0.001). There was no difference in mutant cell levels between males and females (P = 0.463) or smokers and non-smokers (P = 0.186). In the endoscopy group, aspirin users had lower mutant frequencies (P = 0.001). Further information on diet and exercise was available for the endoscopy patient group alone, where those with a higher health promotion index score had lower mutant frequencies (P = 0.011). Higher dietary intake of vegetables reduced mutant cell levels (P = 0.022). Participants who exercised for at least 1 h a week appeared to have reduced mutant frequencies than those who did not exercise, although this was not statistically significant (P = 0.099). This low background level of mutant erythrocytes in a population makes this assay an attractive tool to monitor exposures such as those associated with lifestyles and diet, as demonstrated here.
Causal manipulation of feed-forward and recurrent processing differentially affects measures of consciousness
Authors: Allen Christopher , Viola Tommaso , Irvine Elizabeth , Sedgmond Jemma , Castle Heidi , Gray Richard , Chambers Christopher D 
Published: September 2020

Abstract
It has been theorized that cortical feed-forward and recurrent neural activity support unconscious and conscious cognitive processes, respectively. Here we causally tested this proposition by applying event-related transcranial magnetic stimulation (TMS) at early and late times relative to visual stimuli, together with a pulse designed to suppress conscious detection. Consistent with pre-registered hypotheses, early TMS affected residual, reportedly ‘unseen’ capacity. However, conscious perception also appeared critically dependent upon feed-forward processing to a greater extent than the later recurrent phase. Additional exploratory analyses suggested that these early effects dissociated from top-down criterion measures, which were most affected by later TMS. These findings are inconsistent with a simple dichotomy where feed-forward and recurrent processes correspond to unconscious and conscious mechanisms. Instead, different components of awareness may correspond to different phases of cortical dynamics in which initial processing is broadly perceptual whereas later recurrent processing might relate to decision to report.
Understanding Heterogeneous Effects of Performance Management: An Application of Kroll’s Contingency Approach to Educational Accountability
Authors: Gigliotti Philip 
Published: September 2020

Abstract
Performance Management (PM) systems are intended to inform managerial decision-making, driving performance improvements through managerial reforms. Despite the prevalence of these systems, they were implemented with little evidence of the assumed relationship between PM and organizational performance. Since 2010, a literature on this relationship has developed, but it is heterogeneous and inconclusive. This review develops a theoretical framework of heterogeneous PM effects adapted from Kroll (2015, Public Performance & Management Review, 39, 7–32) and assesses it for consistency with empirical evidence from three cases of educational accountability reforms. This framework assumes that effects of PM systems are driven by the effectiveness of an organization’s managerial response, which is determined by adopting one of three strategies: prospecting, reacting, or gaming. The cases demonstrate that organizational strategy, as inferred from managerial response, predicts performance under accountability. This raises questions about how to predict managerial response, suggesting that managerial autonomy plays an important role.
Discovery of two ‘chimeric’ Gastrotricha and their systematic placement based on an integrative approach
Authors: Kieneke Alexander , Todaro M Antonio 
Published: September 2020

AbstractSublittoral sand from the islands of Sardinia (Italy) and Flores (Azores) – separated by more than 3700 km linear distance and 8 years between two independent sampling campaigns – yielded conspicuous specimens of two bizarre, yet undescribed, species of the marine gastrotrich clade Macrodasyida. These gastrotrichs combine several character traits that were already known from two, non-related genera. Morphological data were carefully analysed and digitally documented, and nuclear and mitochondrial DNA sequences were used for phylogenetic inference. The results of these analyses claim for the erection of a new genus. Specimens of the new taxon have a body length of less than 400 µm and are characterized by a wide, funnel-shaped mouth opening shielded dorsally by an oral hood and possess a posterior peduncle that ends with a Y-shaped pair of appendages that carry the posterior adhesive tubes. Further tubes occur as anterior, ventrolateral and lateral series; the gonads are unpaired and there is a set of two accessory reproductive organs. Molecular phylogenetic analyses confirm the results of former studies and clearly place the new taxon in Thaumastodermatidae. We hereby propose the establishment of Chimaeradasys gen. nov. and describe C. oligotubulatus sp. nov. from the Azores and C. polytubulatus sp. nov. from Sardinia.
Clinical Features of Trousseau Syndrome With Cerebral Infarction as the Initial Manifestation
Authors: Ren Ruifang , Yan Haiqing , Gui Yongkun , Zhao Jun , Wang Haoliang , Ji Danxia , Song Jinggui , Zhang Ping 
Published: September 2020

Objective:
There are few reports of Trousseau syndrome with cerebral infarction as the initial manifestation before the discovery of the tumor, which is often missed and misdiagnosed, and there is no unified therapy. To explore the clinical features of the Trousseau syndrome and, among those features, the risk factors for cerebral infarction as the initial manifestation.

Methods:
This was a retrospective study of 416 consecutive patients with cerebral infarction and malignant tumor admitted at The First Affiliated Hospital of Xinxiang Medical University between January 2015 and December 2017. The patients were grouped as: (1) cerebral infarction as the initial manifestation; and (2) tumor as the initial manifestation. A multivariable logistic regression analysis was used to analyze the relationship between the clinical features (age, sex, characteristics of the infarction, characteristics of the tumors, treatments, depression, coagulopathy, The National Institute of Health stroke scale score, platelet count, red cell count, hemoglobin, atherosclerosis, and coagulation parameters) and the hypercoagulable state.

Results:
A total of 416 patients met the criteria were included: 212 (51.0%) in the group with cerebral infarction as the initial manifestation and 204 (49.0%) in the group with tumor as the initial manifestation. The multivariable analysis showed that metastatic cancer (odds ratio=2.517; 95% confidence interval, 1.193-5.311; P=0.015) and depressive state (odds ratio=3.158; 95% confidence interval, 1.522-6.551; P=0.002) were independently associated with the Trousseau syndrome with cerebral infarction as the main manifestation.

Conclusions:
Trousseau syndrome with cerebral infarction as the initial manifestation was associated with metastatic cancer and depressive state. There was no difference in coagulation status between the 2 groups.
Prevalence of Sarcopenia and Whole-Body Composition in Rheumatoid Arthritis
Authors: Brance María Lorena , Di Gregorio Silvana , Pons-Estel Bernardo A. , Quagliato Norberto J. , Jorfen Marisa , Berbotto Guillermo , Cortese Noel , Raggio Juan C. , Palatnik Mariano , Chavero Ignacio , Soldano Juan , Wong Romulo , Del Rio Luis , Sánchez Ariel , Brun Lucas R. 
Published: September 2020

Background
Rheumatoid arthritis (RA) is a chronic autoimmune disease that leads to joint deformity and disability, as well as muscle involvement. Sarcopenia is characterized by a progressive age-related loss of muscle mass and strength.

Aim
The aim of this study was to evaluate the prevalence of sarcopenia and possible contributing factors associated with sarcopenia in RA patients.

Patients and Methods
Adult RA patients (n = 105) of both sexes and 100 subjects as control group (CG) matched by age, sex, and body mass index were included in this cross-sectional study. Whole-body composition was measured by dual-energy x-ray absorptiometry. Sarcopenia was defined according to European Working Group on Sarcopenia in Older People 2 as low muscle strength (handgrip) and low muscle mass (appendicular skeletal muscle mass [ASM] index by dual-energy x-ray absorptiometry). The association between sarcopenia and associated factors was evaluated using logistic regression analyses.

Results
Significantly lower percentage of lean mass and ASM were found in the whole RA group compared with controls. However, lower lean parameters (total lean mass, percentage of lean mass, and ASM) were observed only in female subjects. The ASM index was significantly lower in female subjects with RA (RA 31.0% vs CG 11.9%) without differences in male subjects. On the other hand, fat mass and most adipose indices were significantly higher in both female and male subjects with RA. Female RA patients had higher prevalence of sarcopenia and sarcopenic obesity. Through univariate logistic regression analysis, the time of corticosteroids use, cumulative corticosteroid dose, previous fragility fractures, total lean mass, and ASM were associated with sarcopenia.

Conclusions
Higher prevalence of sarcopenia and sarcopenic obesity were found in female RA patients. Sarcopenia was found in younger female subjects with RA compared with healthy control subjects. Sarcopenia was associated with previous fragility fractures in female patients with RA.
Determinants of Diagnostic Delay in Complex Regional Pain Syndrome Type 1
Authors: Varenna Massimo , Crotti Chiara , Ughi Nicola , Zucchi Francesca , Caporali Roberto 
Published: September 2020

Background/Objective
Complex regional pain syndrome type 1 (CRPS-1) is a disabling painful disease, with variable outcomes in terms of chronic pain and disability. A long time between onset and diagnosis seems predictive for late recovery and progression toward a chronic disease. This study aims to investigate demographic and clinical variables associated with delayed CRPS-1 diagnosis.

Methods
From March 2013 to January 2018, consecutive patients newly diagnosed according to International Association for the Study of Pain diagnostic criteria for CRPS-1 were recruited. Demographic and clinical variables were collected at diagnosis. Student t test and Mann-Whitney U test were used for comparisons; Cox proportional hazards model was applied to evaluate the variables associated with delayed CRPS-1 diagnosis.

Results
One hundred eighty patients entered the study. At diagnosis, women were older, and foot was more often involved than hand. The triggering event was more commonly a trauma without fracture for foot disease and a fracture for hand localization. No differences between hand and foot disease were found by the International Association for the Study of Pain diagnostic categories (clinical vs research) or pain measures. Variables significantly associated with a longer time between disease onset and diagnosis were foot localization, general practitioner referral, higher number of visits before CRPS diagnosis, and prior physiotherapy prescribed for symptoms later diagnosed as CRPS. An overt clinical manifestation (research CRPS-1) predicted a shorter delay.

Conclusions
Foot localization, prior physiotherapy prescribed for symptoms later diagnosed as CRPS, and a disease without overt clinical manifestations were independent predictive factors for a delayed diagnosis. Clinicians should pay attention to these issues to ensure a timely diagnosis and possibly avoid progression toward a chronic disease.
Diverse outcomes of controlled human malaria infection originate from host-intrinsic immune variation and not var gene switching
Authors: Milne Kathryn , Ivens Alasdair , Reid Adam J. , Lotkowska Magda E. , O’Toole Áine , Sankaranarayanan Geetha , Sandoval Diana Muñoz , Nahrendorf Wiebke , Regnault Clement , Edwards Nick J. , Silk Sarah E. , Payne Ruth O. , Minassian Angela M. , Venkatraman Navin , Sanders Mandy , Hill Adrian V.S. , Barrett Michael P. , Berriman Matthew , Draper Simon J. , Rowe J. Alexandra , Spence Philip J. 
Published: September 2020

AbstractFalciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, asking whether this relationship underpins the variation observed in controlled human malaria infection (CHMI). We uncovered marked heterogeneity in the response of naive hosts to blood challenge; some volunteers remained quiescent, others triggered interferon-stimulated inflammation and some showed transcriptional evidence of myeloid cell suppression. Significantly, only inflammatory volunteers experienced hallmark symptoms of malaria. When we tracked temporal changes in parasite VSA expression to ask whether variants associated with severe disease preferentially expand in naive hosts (as predicted by current theory) we found that var gene profiles were unchanged after 10-days of infection. The diverse outcomes of CHMI therefore depend upon human immune variation and there is no evidence for switching or selection of var genes in naive hosts.