bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compreendendo o conceito território a partir da linguagem fílmica: a animação “O Rei Leão” como possibilidade didática no ensino de Geografia
Authors: Silva Felipe Santos , Gama Lívia Thaysa Santos de Albuquerque , Bráz Maria Luiza 
Published: February 2020

RESUMO: O ensino de Geografia tem sido problematizado nos últimos anos e novas abordagens metodológicas têm sido propostas à luz da superação de metodologias tradicionais de ensino. Visando preencher uma lacuna existente na teoria que envolve as metodologias do ensino de geografia, o presente artigo busca propor a utilização da linguagem fílmica para o entendimento do conceito território a partir da animação “O Rei Leão”. A linguagem fílmica, agregada ao entendimento do conceito território, apresenta-se como uma possibilidade ao ensino de Geografia, por ser capaz de aproximar o conceitual – que muitas vezes parece distante dos alunos – a realidade concreta. Assim, acredita-se que esta proposta seja capaz de proporcionar o desenvolvimento de habilidades e competências no que tange a esse campo de aprendizagem, principalmente por permitir que a complexidade teórica do conceito território seja desvendada a partir de uma linguagem interativa e prazerosa como a linguagem fílmica, que, mesmo sendo de fácil acesso, ainda possui alguns entraves no campo do ensino, principalmente no que diz respeito às dificuldades de planejamento.
PALAVRAS-CHAVE: Ensino de Geografia. Território. Didática. Linguagem fílmica.
LEGAL RESTRICTION OF BANKRUPTCY OF STATE-OWNED ENTERPRISE (SEO) AND SUSTAINABILITY: THE CASE OF INDONESIA
Authors: Shubhan M. Hadi , Indrawati  , CR Dri Utari 
Published: February 2020

Purpose of Study: This research examines the possibility of state-owned enterprises being nailed in the legal system in Indonesia. According to the bankruptcy regulation in Indonesia, those who are unable to pay debts can be declared bankrupt by the creditors, including SOEs. However, other regulations state that the government’s assets (including those within SOEs) cannot be confiscated, including within bankruptcy confiscation.
Methodology: The research method used in this study is qualitative research using the type of doctrinal law research. The approach used is to use the statutory approach, conceptual approach, and case approach. Data from this study were obtained from commercial courts in Jakarta and Surabaya.
Main Findings: This study found that there was a desynchronization of the regulations regarding the SOEs’ bankruptcy, i.e., between the Bankruptcy Law and the other laws, and even points within the Bankruptcy Law itself. The example that can be taken in this study is PT Kertas Leces /Limited Liability Company (LLC) Kertas Leces) that had already gone bankrupt and experienced confiscation of its bankrupt assets.
Implications: The ideal bankruptcy model for SOEs is that the bankruptcy applicants for SOEs in the form of public companies or state-owned companies should be the Minister of Finance. The Ministry of Finance is responsible for the operational policies and supervision of SOEs, amounting to approximately 115 companies in the form of public companies or state-owned companies, including those that have already gone public and those which have not.
Novelty: Previous studies have only focused on the assets of state-owned enterprises that have been separated and therefore bankrupt. This study examines another matter, namely that not all state-owned enterprises can be declared bankrupt and found one state-owned bankruptcy.
Fossil capitalism, climate capitalism, energy democracy: the struggle for hegemony in an era of climate crisis
Authors: Carroll William K. 
Published: February 2020

With the highest per capita carbon emissions among the G20, Canada presents the interesting case of a climate laggard and, in some respects, a first-world petro-state. In these circumstances, a regime of obstruction, with a distinctive political-economic architecture, has taken shape. This regime is constituted through modalities of power that protect revenue streams issuing from carbon extraction, processing and transport while bolstering popular support for an accumulation strategy in which fossil capital figures as a leading fraction. It incorporates a panoply of hegemonic practices at different scales, reaching into civil and political society, and into Indigenous communities whose land claims and worldviews challenge state mandated property rights. This article first highlights findings from a seven-year collaborative investigation of the modalities through which fossil capital’s economic and political-cultural power is exercised at different scales; then outlines how the passive-revolutionary project of ‘climate capitalism’ is taking shape in the Canadian context as a response to climate crisis; and finally considers how a project of energy democracy might hold the potential to catalyze the formation of an alternative historical bloc.
Permian Fusulinid Rugososchwagerina (Xiaoxinzhaiella) from the Shan Plateau, Myanmar: Systematics and Paleogeography
Authors: Huang Hao , Jin Xiaochi , Shi Yukun 
Published: February 2020

AbstractEastern Myanmar is an indispensable part of the Cimmerian Continent with Gondwana provenance. Fusulinids from Eastern Myanmar remain poorly known despite their biochronological and paleogeographical significance. This paper describes Rugososchwagerina (Xiaoxinzhaiella) subrotunda sp. nov. and Chusenella quasidouvillei of Murgabian age (Middle Permian) from the Thitsipin Formation at the Pindaya in the Shan Plateau, Eastern Myanmar. Taxonomic analysis of this new collection and of Rugososchwagerina (s.l.) in the literature leads us to suppress Xiaoxinzhaiella Shi, Yang & Jin, 2005 as a subgenus of RugososchwagerinaMiklukho-Maklay, 1959. This subgenus is diagnosed with much tighter coiling and reduced septal folding in juvenarium as well as relatively smaller test diameter throughout the ontogeny, compared with Rugososchwagerina (s.s.) which is typified by R. yabeiSkinner & Wilde, 1966. Furthermore, our comprehensive review reveals that the known occurrences of R. (Xiaoxinzhaiella) are strictly confined within blocks that previously constituted the Cimmerian Continent during the Permian period, and they were even more widespread than Rugososchwagerina (s.s.) among these blocks. Therefore, the previous understanding that Rugososchwagerina (s.l.) is characteristic for the Middle Permian Cimmerian region can be refined. We propose that R. (Xiaoxinzhaiella) is more appropriate as the truly endemic foraminiferal index signifying Cimmerian affinity.
Review of Refinery Engineering
Authors: Miller Walter 
Published: February 2020

Published in Petroleum Transactions, AIME, Volume 174, 1948, pages332–336.
Crude oil stocks were some 10,000,000 bbl higher on June 1, 1947, than atany time during 1946 but the extremely heavy refinery runs the last half of1947 cut crude inventories to approximately the 1946 closing level of225,000,000 bbl.' Many refiners were seriously short of crude oil during theyear. This shortage was reflected in numerous advances in the posted price ofcrude, justified in part as an incentive for more production but more generallydue to competitive bidding. Some purchasers of crude, endeavoring to keep theirplants running, resorted to the payment, either directly or indirectly, ofpremiums above the posted price. Another common practice employed by somesuppliers of crude oil was to demand refined products in exchange or trade fortheir raw material. The refined products picture has darkened in spite ofrecord throughputs. Stocks of gasoline and light and heavy fuel oils wereuncomfortably low at the beginning of the year and were in general still lowerat the close. The rationing of some products, principally gasoline, to dealersand stations, initiated during the year, gained momentum as stocks continued todiminish. The emphasis placed by the manufacturers of oil-burning equipment onthe convenience and economy of heating with oil, together with the tightsituation in coal, has developed a tremendous demand for burning oils.Consumption of liquefied petroleum gas for domestic and household fuel had morethan doubled in 1946 over 1943, and the demand seems to be limited only by theability of the equipment builders to furnish necessary storage, transportation, and burning equipment.
The supply situation is likely to become more acute in 1948. Demand forpetroleum products is being pushed to new heights not only by the unprecedenteddomestic market but by a sudden and drastic upswing in estimates of militaryand governmental requirements. Additionally, oil exports are running far belowthe volume requested, amounting to less than forty percent in a recent quarter, and export licenses are reportedly being approved on the basis of urgent needonly. A recent White House release sees little likelihood that estimatedrequirements of the sixteen nations participating in the proposed Marshall Plancan be met in full over its projected life-1948 to 1951.
Present demand dictates maintenance of refinery operations at the highestpossible level and the Bureau of Mines has forecast daily average crude runs in1948 of 5,265,000 bbl. The Economics Advisory Committee of the Interstate OilCompact Commission recently estimated the 1948 demand for petroleum products atnearly 6 pct above 1947. They further estimate daily average crude runs of5,375,000 bbl in 1948, some 2 pct higher than forecast by the Bureau ofMines.
Projected demand exceeds supply to the extent that Capitol Hill is reportedlyinvestigating ways of enabling oil companies to act in concert without dangerof antitrust prosecution, such as elimination of crosshauls, pooling ofproducts, and lowering of octane.
Rapid and High-resolution Imaging of Lumpectomy Margins Using Deep Ultraviolet Fluorescence Scanning Microscopy
Authors: Lu Tongtong , Jorns Julie M , Patton Mollie , Fisher Renee , Emmrich Amanda , Doehring Todd , Gilat-Schmidt Taly , Ye Dong Hye , Yen Tina , Yu Bing 
Published: February 2020

Abstract
Background: Re-excision rates for women with invasive breast cancer undergoing breast conserving surgery (BCS or lumpectomy) have decreased in the past decade but remain substantial. This is mainly due to the inability to efficiently and accurately assess the entire surface of an excised lumpectomy specimen during surgery. To address this problem, a deep-ultraviolet scanning fluorescence microscope (DUV-FSM) imaging system was developed and evaluated to determine whether it could accurately detect cancer cells on the surface of excised breast tissue.Methods: 37 (22 malignant and 15 normal/benign) fresh breast tissue samples of variable size were stained in propidium iodide and eosin Y solutions. A set of fluorescence images were obtained from one side of each sample using low magnification (4x) and fully automated scanning. The images from each sample were stitched to form a color image. Routine histopathology was performed on each sample. Three non-medical inspectors were trained to interpret and assess the fluorescence images. Patch-level nuclear-cytoplasm ratio (N/C) was calculated and ROC analysis with the Youden index was used for tissue classification. Results: DUV-FSM images a breast sample with subcellular resolution at a speed of 1.0 minute/cm2. DUV images show excellent visual contrast in color, tissue texture, cell density and shape between invasive lobular carcinoma (ILC), invasive ductal carcinoma (IDC) and their normal counterparts. Visual interpretation of DUV images was able to distinguish invasive carcinoma from normal/benign samples with high sensitivity (95%) and specificity (94.4%). Pairwise comparison of patch-level N/C identified significant differences (p<0.001) between normal and malignant samples. Using N/C alone was able to differentiate invasive carcinoma from normal breast tissues at the patch-level, with reasonable sensitivity (81.3%) and specificity (79.2%). Conclusions: DUV-FSM is a simple device that can rapidly image large, unprocessed breast specimens with subcellular resolution and excellent contrast which allows either visual or quantitative detection of invasive cancer cells on the surfaces of a surgical specimen. This study supports further investigation into whether this technology can be used for intraoperative assessment of surgical margins during BCS procedures.
Chronic Schistosomiasis, a Clinical and Laboratory Diagnostic Challenge in Malawi
Authors: Kamudumuli Pocha Samuel , Sinyiza Frank Watson , Chisale Master R.O. , Kaira Alfred , Kaseka Paul , Wu Joseph , Chingatichifwe Balwani Mbakaya , Chimbatata Chikondi Sharon 
Published: February 2020

Abstract
Objective: Schistosomiasis cause significant morbidity and mortality worldwide. This is a retrospective cross-sectional study conducted at Mzuzu Central Hospital (MCH) from northern Malawi aiming at determining prevalence of schistosomiasis infection in cancer suspected patients. The data was collected from hospital files and the duration under review was from July 2013 to June 2018. A total of 790 Histopathological samples were analysed at University of North Carolina (UNC) Histopathology lab. Results were made available to the facility – Mzuzu Central Hospital.Results: The overall prevalence of schistosoma (S. mansoni & haematobium) infection was 1.7% (14/790). About 93% (13/14) of schistosomiasis cases were observed in female patients while 7% (1/14) from male patients. Of the 14 cases from different histopathological pattern (Cervix, Ureter, Liver, Ovary, GIT and Urinary bladder), 43% (6/14) of cases were diagnosed from cervical tissues. Correlation between HIV infection and schistosomiasis infection was not reached as Serostatus for reasonable number of patients was unknown. Schistosomiasis chronic infection is highly prevalent in Malawi. This disease is neglected and underestimated due to lack of clinical skills and capacity in most of the public laboratories to accurately diagnose it as such, most cases are misdiagnosed as cancer.
Anti-tumor effects of LncRNA-CR594175 silenceing on hepatocellular carcinoma cell line HepG2 in vivo and in vitro
Authors: Liu Quan , Yu Xuxu , Yang Minjie , Li Xiangke , Zhai Xuejia , Lian Yujin , Chen Zhong , Fan Qingxia , Song Lijie , Li Wecai 
Published: February 2020

Abstract
Background Hepatocellular carcinoma (HCC) is one of the cancers of highest incidence and mortality worldwide. Methods High-throughput screening was applied to find the most varied expressed LncRNA in primary hepatocellular carcinoma and explore the interaction network of it. Results We found that lncRNA-CR594175 was the lncRNA of most varied expression, which was lower in adjacent noncancerous tissues than in primary HCC, and was lower in primary HCC than in its metastases. Knockdown of CR594175 inhibited the proliferation and invasion of HCC cells HepG2. The mechanism study revealed that CR594175, as a RNA sponge, broke the negative regulation of CTNNB1 (Catenin, beta-1) by hsa-miR142-3p, and once CR594175 was silenced, the highly expressed hsa-miR142-3p regained its regulation on CTNNB1 and inhibited the proliferation and invasion through Wnt signaling pathway. Conclusions Our present study demonstrates for the first time that CR594175 silencing suppressed proliferation and invasion of HCC cells HepG2 in vivo and in vitro by restoring the negative regulation of CTNNB1 by hsa-miR142-3p, laying a solid theoretic base for using lncRNA-CR594175 as genetic therapy target for HCC and offering a reasonable explanation for inactivation of miRNA in difference tumors or tumor of different stages.
Identification of Nucleus Sterility Candidate Genes using a Resequencing Technique in Sweet Pepper Sterile Line AB91
Authors: Fan Yanqin , Meng Yaning , Yan Libin , Zhang Hongxiao 
Published: February 2020

Abstract
Breeding hybrids with nuclear male sterile lines is an important method for the cross breeding of sweet peppers. To date, few reports have been published on the nuclear male sterility gene of sweet pepper. Yet, there are approximately 20 pepper nuclear male sterility lines in the world. Using the self-developed testing material, sweet pepper nuclear male sterile dual-purpose line AB91, the genome-wide resequencing technique was applied to firstly find that the mutation site causing the abortion of sweet pepper nuclear male sterility AB91 is on chromosome #5. The mutation gene Capana05g000747 was filtered out and validated by the flight mass spectrometry genotyping method and determined to be the gene causing the abortion of sweet pepper nuclear male sterility AB91. The gene Capana05g000747 contains eight exons and seven introns, and its mutation site is a non-synonymous mutation site located at the 6th exon; the base C mutated into A, and the amino acid changed from alanine to serine. Sequence alignment analysis showed that the gene Capana05g000747 has a similar function to gene At2g02148. The gene At2g02148 contains a pentatricopeptide repeat protein which has important physiological functions in the gene expression process of organelles and is closely related to the performance of male sterility genes. Therefore, Capana05g000747 was selected as an important candidate gene for sweet pepper nuclear male sterile testing material AB91.
MMP10 involved in Radiosensitivity in Non-Small Cell Lung Cancer via DNA damage repair pathway
Authors: Lei Xiao , Chen Yuanyuan , Ma Na , Zhang Pei , Han Yanan , Du Lehui , Qu Baolin 
Published: February 2020

Abstract
Background Non-small cell lung cancer (NSCLC) is an aggressive subtype of lung cancer with high mortality and morbidity. Our purpose in this study is to investigate the effect of MMP10 in NSCLC during radiotherapy and its mechanism. Materials and methods We analyzed MMP10 expression and overall survival rate of patients via UALCAN analysis. Western blot analysis was used to test the protein expression. We applied clonogenic assay and apoptosis assay to detect radioresistance in vitro. The level of DNA damage and the DNA damage repair were disclosed via comet assay and γH2AX foci assay. Results Our results showed that high MMP10 expression in Lung Adenocarcinoma specimens is associated with poor outcomes of patients. Knockdown MMP10 induced radiosensitization in A549 cells via clonogenic assay and apoptosis assay. Furthermore, we found MMP10 siRNA enhanced DNA damage of NSCLC cells and MMP10 involved in DNA damage repair after IR. Conclusion Our data highlighted that MMP10 plays a crucial role in NSCLC after radiation via DNA damage repair pathway, and the regulating effect of MMP10 on radiosensitivity in NSCLC might confer to therapeutic implications to NSCLC radiotherapy.
Favorable Effects of Astaxanthin on Brain Damage due to Ischemia- Reperfusion Injury
Authors: Cakir Esra , Cakir Ufuk , Tayman Cuneyt , Turkmenoglu Tugba Taskin , Gonel Ataman , Turan Isil O. 
Published: February 2020

Background:Activated inflammation and oxidant stress during cerebral ischemia reperfusion injury (IRI) lead to brain damage. Astaxanthin (ASX) is a type of carotenoid with a strong antioxidant effect.Objective:The aim of this study was to investigate the role of ASX on brain IRI.Methods:A total of 42 adult male Sprague-Dawley rats were divided into 3 groups as control (n=14) group, IRI (n=14) group and IRI + ASX (n=14) group. Cerebral ischemia was instituted by occluding middle cerebral artery for 120 minutes and subsequently, reperfusion was performed for 48 hours. Oxidant parameter levels and protein degradation products were evaluated. Hippocampal and cortex cell apoptosis, neuronal cell count, neurological deficit score were evaluated.Results:In the IRI group, oxidant parameter levels and protein degradation products in the tissue were increased compared to control group. However, these values were significantly decreased in the IRI + ASX group (p<0.05). There was a significant decrease in hippocampal and cortex cell apoptosis and a significant increase in the number of neuronal cells in the IRI + ASX group compared to the IRI group alone (p<0.05). The neurological deficit score which was significantly lower in the IRI group compared to the control group was found to be significantly improved in the IRI + ASX group (p<0.05).Conclusion:Astaxanthin protects the brain from oxidative damage and reduces neuronal deficits due to IRI injury.
Extremely-randomized-tree-based Prediction of N6-methyladenosine Sites inSaccharomyces cerevisiae
Authors: Govindaraj Rajiv G. , Subramaniyam Sathiyamoorthy , Manavalan Balachandran 
Published: February 2020

Introduction:N6-methyladenosine (m6A) is one of the most common post-transcriptional modifications in RNA, which has been related to several biological processes. The accurate prediction of m6A sites from RNA sequences is one of the challenging tasks in computational biology. Several computational methods utilizing machine-learning algorithms have been proposed that accelerate in silico screening of m6A sites, thereby drastically reducing the experimental time and labor costs involved.Methodology:In this study, we proposed a novel computational predictor termed ERT-m6Apred, for the accurate prediction of m6A sites. To identify the feature encodings with more discriminative capability, we applied a two-step feature selection technique on seven different feature encodings and identified the corresponding optimal feature set.Results:Subsequently, performance comparison of the corresponding optimal feature set-based extremely randomized tree model revealed that Pseudo k-tuple composition encoding, which includes 14 physicochemical properties significantly outperformed other encodings. Moreover, ERT-m6Apred achieved an accuracy of 78.84% during cross-validation analysis, which is comparatively better than recently reported predictors.Conclusion:In summary, ERT-m6Apred predicts Saccharomyces cerevisiae m6A sites with higher accuracy, thus facilitating biological hypothesis generation and experimental validations.