bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell-based and cell-free biocatalysis for the production of d-glucaric acid
Authors: Chen Lu-Zhou , Huang Si-Ling , Hou Jin , Guo Xue-Ping , Wang Feng-Shan , Sheng Ju-Zheng 
Published: December 2020

Abstractd-Glucaric acid (GA) is a value-added chemical produced from biomass, and has potential applications as a versatile platform chemical, food additive, metal sequestering agent, and therapeutic agent. Marketed GA is currently produced chemically, but increasing demand is driving the search for eco-friendlier and more efficient production approaches. Cell-based production of GA represents an alternative strategy for GA production. A series of synthetic pathways for GA have been ported intoEscherichia coli,Saccharomyces cerevisiaeandPichia pastoris, respectively, and these engineered cells show the ability to synthesize GA de novo. Optimization of the GA metabolic pathways in host cells has leapt forward, and the titer and yield have increased rapidly. Meanwhile, cell-free multi-enzyme catalysis, in which the desired pathway is constructed in vitro from enzymes and cofactors involved in GA biosynthesis, has also realized efficient GA bioconversion. This review presents an overview of studies of the development of cell-based GA production, followed by a brief discussion of potential applications of biosensors that respond to GA in these biosynthesis routes.
Changes in cancer incidence and mortality in Australia over the period 1996–2015
Authors: Luo Qingwei , Steinberg Julia , O’Connell Dianne L. , Grogan Paul B. , Canfell Karen , Feletto Eleonora 
Published: December 2020

Abstract
Objective
A previous Australian study compared the observed numbers of cancer cases and deaths in 2007 with the expected numbers based on 1987 rates. This study examines the impact of cancer rate changes over the 20-year period 1996–2015, for people aged under 75 years.

Results
The overall age-standardised cancer incidence rate increased from 350.7 in 1995 to 364.4 per 100,000 in 2015. Over the period 1996–2015, there were 29,226 (2.0%) more cases (males: 5940, 0.7%; females: 23,286, 3.7%) than expected numbers based on 1995 rates. Smaller numbers of cases were observed compared to those expected for cancers of the lung for males and colorectum, and cancers with unknown primary. Larger numbers of cases were observed compared to those expected for cancers of the prostate, thyroid and female breast. The overall age-standardised cancer mortality rate decreased from 125.6 in 1995 to 84.3 per 100,000 in 2015. During 1996 to 2015 there were 106,903 (− 20.6%) fewer cancer deaths (males: − 69,007, − 22.6%; females: − 37,896, − 17.9%) than expected based on the 1995 mortality rates. Smaller numbers of deaths were observed compared to those expected for cancers of the lung, colorectum and female breast, and more cancer deaths were observed for liver cancer.
Identifying elephant flows using dynamic thresholds in programmable IXP networks
Authors: Silva Marcus Vinicius Brito da , Marques Jonatas Adilson , Gaspary Luciano Paschoal , Granville Lisandro Zambenedetti 
Published: December 2020

AbstractInternet eXchange Points (IXPs) are Internet infrastructures composed of high-performance networks that allow multiple autonomous systems to exchange traffic. Given the challenges of managing the flows that cross an IXP, identifying elephant flows may help improve the quality of services provided to its participants. In this context, we leverage the new flexibility and resources of programmable data planes to identify elephant flows in IXP networks adaptively via the dynamic adjustment of thresholds. Our mechanism uses the information reported by the data plane to monitor network utilization in the control plane, calculating new thresholds based on previous flow sizes and durations percentiles and configuring them back into switches to support the local classification of flows. Thus, the thresholds are updated to make the identification process better aligned with the network behavior. The experimental results show that it is possible to identify and react to elephant flows quickly, less than 0.4ms, and efficiently, with only 98.4KB of data inserted into the network by the mechanism. In addition, the threshold updating mechanism achieved accuracy of up to 90% in our evaluation scenarios.
European Society of Emergency Radiology: guideline on radiological polytrauma imaging and service (short version)
Authors: Wirth Stefan , Hebebrand Julian , Basilico Raffaella , Berger Ferco H. , Blanco Ana , Calli Cem , Dumba Maureen , Linsenmaier Ulrich , Mück Fabian , Nieboer Konraad H. , Scaglione Mariano , Weber Marc-André , Dick Elizabeth 
Published: December 2020

Abstract
Background
Although some national recommendations for the role of radiology in a polytrauma service exist, there are no European guidelines to date. Additionally, for many interdisciplinary guidelines, radiology tends to be under-represented. These factors motivated the European Society of Emergency Radiology (ESER) to develop radiologically-centred polytrauma guidelines.

Results
Evidence-based decisions were made on 68 individual aspects of polytrauma imaging at two ESER consensus conferences. For severely injured patients, whole-body CT (WBCT) has been shown to significantly reduce mortality when compared to targeted, selective CT. However, this advantage must be balanced against the radiation risk of performing more WBCTs, especially in less severely injured patients. For this reason, we recommend a second lower dose WBCT protocol as an alternative in certain clinical scenarios. The ESER Guideline on Radiological Polytrauma Imaging and Service is published in two versions: a full version (download from the ESER homepage, https://www.eser-society.org) and a short version also covering all recommendations (this article).

Conclusions
Once a patient has been accurately classified as polytrauma, each institution should be able to choose from at least two WBCT protocols. One protocol should be optimised regarding time and precision, and is already used by most institutions (variant A). The second protocol should be dose reduced and used for clinically stable and oriented patients who nonetheless require a CT because the history suggests possible serious injury (variant B). Reading, interpretation and communication of the report should be structured clinically following the ABCDE format, i.e. diagnose first what kills first.
A smart scaffold composed of three-dimensional printing and electrospinning techniques and its application in rat abdominal wall defects
Authors: Yang Zhi , Song Zhicheng , Nie Xin , Guo Kaijin , Gu Yan 
Published: December 2020

Abstract
Background
Biological composite scaffolds are increasingly being used in abdominal wall reconstruction but still have certain shortcomings. The present study describes here a novel three-dimensional (3D) scaffold fabricated by combining 3D printing (3DP) and electrospinning (ESP).

Methods
Biological composite scaffolds are composed of integrated 3DP interconnected macrofiber and random ESP microfiber networks. The 3DP scaffold retains intact 3D architecture and mechanical properties, while the ESP network serves as a cell entrapment system at the extracellular matrix (ECM) scale. Biological composite scaffolds are implanted in a defective rat abdominal wall to detect if it could induce early vascularization and reconstruction of the tissue defect.

Results
SEM analysis reveals a pore diameter of 424.47 ± 58.49 μm and a porosity of 70.46 ± 2.48% for biological composite scaffolds. In the in vitro test of cell proliferation, biological composite scaffolds do not affect rat dermal fibroblast proliferation in a time- and dose-dependent manner. The animal experiments show tissue remodeling and early angiogenesis as compared to 3DP scaffolds.

Conclusions
Our experiment prepares a biological scaffold with both a macro- and microscale structure by ESP and 3DP technology. Thus, the integration of 3DP and ESP techniques provides a new set of smart scaffolds for abdominal wall defect and hernia repair.
Regulatory T cell induction by mesenchymal stem cells depends on the expression of TNFR2 by T cells
Authors: Naserian Sina , Shamdani Sara , Arouche Nassim , Uzan Georges 
Published: December 2020

AbstractMesenchymal stem/stromal cells can modulate the effector immune cells especially T lymphocytes. Due to this important feature, they can regulate the development of a variety of disorders including inflammatory and autoimmune disorders, cancers, and transplantation outcomes. One of the most important MSC immunoregulatory functions is their capacity to convert conventional T cells into regulatory T cells. Several mechanisms, mostly related to MSCs but not T cells, have been shown essential for this aspect. The inflammatory microenvironment majorly caused by pro-inflammatory cytokines has been demonstrated to govern the direction of the immune response. In this respect, we have recently revealed that the TNFα-TNFR2 signaling controls several aspects of MSC immunomodulatory properties including their ability to suppress T cells and their conversion towards Foxp3-expressing Tregs. Here in this work, we have looked from another angle by investigating the impact of TNFR2 expression by T cells on their ability to be converted to suppressive Tregs by MSCs. We showed that unlike WT-T cells, their TNFR2 KO counterparts are remarkably less able to convert into Foxp3+ and Foxp3− Tregs. Furthermore, TNFR2 blockade diminished the anti-inflammatory cytokine secretion by iTregs and consequently resulted in less T cell immunosuppression. This work is the first evidence of the crucial association of TNFR2 expression by T cells with their iTreg conversion capacity by MSCs. It strengthens once more the potential of anti-TNFR2 administration for a strong and effective interference with the immunosuppression exerted by TNFR2-expressing cells.
Global existence, energy decay and blow-up of solutions for wave equations with time delay and logarithmic source
Authors: Park Sun-Hye 
Published: December 2020

AbstractIn this paper, we study the wave equation with frictional damping, time delay in the velocity, and logarithmic source of the form $$ u_{tt}(x,t) - \Delta u (x,t) + \alpha u_{t} (x,t) + \beta u_{t} (x, t- \tau ) = u(x,t) \ln \bigl\vert u(x,t) \bigr\vert ^{\gamma } . $$

u

t
t

(
x
,
t
)
−
Δ
u
(
x
,
t
)
+
α

u
t

(
x
,
t
)
+
β

u
t

(
x
,
t
−
τ
)
=
u
(
x
,
t
)
ln
|
u
(
x
,
t
)

|
γ

.
There is much literature on wave equations with a polynomial nonlinear source, but not much on the equations with logarithmic source. We show the local and global existence of solutions using Faedo–Galerkin’s method and the logarithmic Sobolev inequality. And then we investigate the decay rates and infinite time blow-up for the solutions through the potential well and perturbed energy methods.
Some inequalities for Csiszár divergence via theory of time scales
Authors: Ansari Iqrar , Khan Khuram Ali , Nosheen Ammara , Pečarić Ðilda , Pečarić Josip 
Published: December 2020

AbstractIn this paper, we present some inequalities for Csiszárf-divergence between two probability measures on time scale. These results extend some known results in the literature and offer new results inh-discrete calculus and quantum calculus. We also present several inequalities for divergence measures.
Clinical physiology aspects of chloremia in fluid therapy: a systematic review
Authors: Astapenko David , Navratil Pavel , Pouska Jiri , Cerny Vladimir 
Published: December 2020

Abstract
Background
This systematic review discusses a clinical physiology aspect of chloride in fluid therapy. Crystalloid solutions are one of the most widely used remedies. While generally used in medicine for almost 190 years, studies focused largely on their safety have only been published since the new millennium. The most widely used solution, normal saline, is most often referred to in this context. Its excessive administration results in hyperchloremic metabolic acidosis with other consequences, including higher mortality rates.

Methods
Original papers and review articles eligible for developing the present paper were identified by searching online in the electronic MEDLINE database. The keywords searched for included hyperchloremia, hypochloremia, and compound words containing the word “chloride,” infusion therapy, metabolic acidosis, renal failure, and review.

Results
A total of 21,758 papers published before 31 May 2020 were identified; of this number, 630 duplicates were removed from the list. Upon excluding articles based on their title or abstract, 1850 papers were screened, of which 63 full-text articles were assessed.

Conclusions
According to the latest medical concepts, dyschloremia (both hyperchloremia and hypochloremia) represents a factor indisputably having a negative effect on selected variables of clinical outcome. As infusion therapy can significantly impact chloride homeostasis of the body, the choice of infusion solutions should always take into account the potentially adverse impact of chloride content on chloremia and organ function.
Deep mantle melting, global water circulation and its implications for the stability of the ocean mass
Authors: Karato Shun-ichiro , Karki Bijaya , Park Jeffrey 
Published: December 2020

AbstractOceans on Earth are present as a result of dynamic equilibrium between degassing and regassing through the interaction with Earth’s interior. We review mineral physics, geophysical, and geochemical studies related to the global water circulation and conclude that the water content has a peak in the mantle transition zone (MTZ) with a value of 0.1–1 wt% (with large regional variations). When water-rich MTZ materials are transported out of the MTZ, partial melting occurs. Vertical direction of melt migration is determined by the density contrast between the melts and coexisting minerals. Because a density change associated with a phase transformation occurs sharply for a solid but more gradually for a melt, melts formed above the phase transformation depth are generally heavier than solids, whereas melts formed below the transformation depth are lighter than solids. Consequently, hydrous melts formed either above or below the MTZ return to the MTZ, maintaining its high water content. However, the MTZ water content cannot increase without limit. The melt-solid density contrast above the 410 km depends on the temperature. In cooler regions, melting will occur only in the presence of very water-rich materials. Melts produced in these regions have high water content and hence can be buoyant above the 410 km, removing water from the MTZ. Consequently, cooler regions of melting act as a water valve to maintain the water content of the MTZ near its threshold level (~ 0.1–1.0 wt%). Mass-balance considerations explain the observed near-constant sea-level despite large fluctuations over Earth history. Observations suggesting deep-mantle melting are reviewed including the presence of low-velocity anomalies just above and below the MTZ and geochemical evidence for hydrous melts formed in the MTZ. However, the interpretation of long-term sea-level change and the role of deep mantle melting in the global water circulation are non-unique and alternative models are reviewed. Possible future directions of studies on the global water circulation are proposed including geodynamic modeling, mineral physics and observational studies, and studies integrating results from different disciplines.
Ensemble flash flood predictions using a high-resolution nationwide distributed rainfall-runoff model: case study of the heavy rain event of July 2018 and Typhoon Hagibis in 2019
Authors: Sayama Takahiro , Yamada Masafumi , Sugawara Yoshito , Yamazaki Dai 
Published: December 2020

AbstractThe heavy rain event of July 2018 and Typhoon Hagibis in October 2019 caused severe flash flood disasters in numerous parts of western and eastern Japan. Flash floods need to be predicted over a wide range with long forecasting lead time for effective evacuation. The predictability of flash floods caused by the two extreme events is investigated by using a high-resolution (~ 150 m) nationwide distributed rainfall-runoff model forced by ensemble precipitation forecasts with 39 h lead time. Results of the deterministic simulation at nowcasting mode with radar and gauge composite rainfall could reasonably simulate the storm runoff hydrographs at many dam reservoirs over western Japan for the case of heavy rainfall in 2018 (F18) with the default parameter setting. For the case of Typhoon Hagibis in 2019 (T19), a similar performance was obtained by incorporating unsaturated flow effect in the model applied to Kanto Region. The performance of the ensemble forecast was evaluated based on the bias ratios and the relative operating characteristic curves, which suggested the higher predictability in peak runoff for T19. For the F18, the uncertainty arises due to the difficulty in accurately forecasting the storm positions by the frontal zone; as a result, the actual distribution of the peak runoff could not be well forecasted. Overall, this study showed that the predictability of flash floods was different between the two extreme events. The ensemble spreads contain quantitative information of predictive uncertainty, which can be utilized for the decision making of emergency responses against flash floods.
Dust emission source characterization for visibility hazard assessment on Lordsburg Playa in Southwestern New Mexico, USA
Authors: Van Pelt R. Scott , Tatarko John , Gill Thomas E. , Chang Chunping , Li Junran , Eibedingil Iyasu G. , Mendez Marcos 
Published: December 2020

AbstractIn drylands around the world, ephemeral lakes (playas) are common. Dry, wind-erodible playa sediments are potent local and regional sources of dust and PM10 (airborne particles with diameters less than 10 μm). Dust clouds often cause sudden and/or prolonged loss of visibility to travelers on downwind roadways. Lordsburg Playa, in southwestern New Mexico, USA is bisected by Interstate Highway 10. Dust storms emanating from the playa have been responsible for numerous visibility-related road closures (including 39 road closures between 2012 and 2019) causing major economic losses, in addition to well over a hundred dust-related vehicle crashes causing at least 41 lost lives in the last 53 years. In order to improve understanding of the surfaces responsible for the dust emissions, we investigated the critical wind friction velocity thresholds and the dust emissivities of surfaces representing areas typical of Lordsburg Playa’s stream deltas, shorelines, and ephemerally flooded lakebed using a Portable In-Situ Wind ERosion Laboratory (PI-SWERL). Mean threshold friction velocities for PM10 entrainment ranged from less than 0.30 m s− 1 for areas in the delta and shoreline to greater than 0.55 m s− 1 for ephemerally flooded areas of the lakebed. Similarly, we quantified mean PM10 vertical flux rates ranging from less than 500 μg m− 2 s− 1 for ephemerally flooded areas of lakebed to nearly 25,000 μg m− 2 s− 1 for disturbed delta surfaces. The unlimited PM10 supply of the relatively coarse sediments along the western shoreline is problematic and indicates that this may be the source area for longer-term visibility reducing dust events and should be a focus area for dust mitigation efforts.
A comparative study of parental knowledge and adaptation of immigrant youth
Authors: Turjanmaa Elina , Jasinskaja-Lahti Inga 
Published: December 2020

AbstractIn general, parental knowledge is known to support adolescents’ adaptation. Less is known about the role of parental knowledge in psychological (i.e., anxiety) and socio-cultural (i.e., school achievement) adaptation of adolescents with immigrant background, and how parental knowledge and social characteristics (i.e., gender, generational status, immigrant background, and family’ socioeconomic background) of immigrant adolescents jointly influence their adaptation outcomes. This study explores the role of adolescent-reported parental knowledge in explaining adaptation outcomes among first- and second-generation immigrant boys and girls from four different immigrant groups. The study utilizes the national Finnish School Health Promotion survey data (N = 2697, 45% female, M age = 15.6 years, SD = .91) and illustrates the complex relationship between parental knowledge and adolescents’ adaptation.
The endogenous development of pastoral society: an anthropological case study in East Ujimqin Banner in Inner Mongolia
Authors: Zhang Kun , Shang Hailin 
Published: December 2020

AbstractThrough empirical research on the social development of pastoral society in the East Ujimqin Banner, this study puts forward that within the government’s “passive development” discourse, local herders would prefer to consciously practice “active development”. This method both respects local culture and traditions, and triggers a shift from exogenous to endogenous development. My study shows that only by cultivating the self-development mechanism of ethnic minorities and the initiative to participate in development can we realize the social development of pastoral areas. The survival practices constructed by the local society according to its traditional mechanisms are not only connected with the external market and the state as modes of production, but also enable the local society’s modes of livelihood to be maintained and the traditional social culture to continue amid the continuous transformation taking place under the impact of pastoral modernization.
Emergency tips recanalisation and gastroesophageal varices embolisation with an ethylene vinyl alcohol copolymer agent (Squid) and detachable coils
Authors: Venturini Massimo , Augello Luigi , Lanza Carolina , Curti Marco , Coppola Andrea , Piacentino Filippo , De Cobelli Francesco 
Published: December 2020

AbstractTransjugular intrahepatic portosystemic shunt (TIPS) is currently indicated as first therapeutic option in the main complications of portal hypertension, including bleeding gastroesophageal varices and refractory ascites. In case of bleeding gastroesophageal varices, an adjuvant embolisation within TIPS can be useful to prevent rebleeding. In the present technical note, the management in emergency of a patient with haemorrhagic shock due to bleeding gastroesophageal varices and occluded TIPS is reported. TIPS recanalisation with an adjunctive stent and high-pressure balloon angioplasty and gastroesophageal varices embolisation using detachable coils and a non-adhesive liquid embolic agent were performed during the same emergent procedure. After the procedure, clinical stabilisation of the patient was achieved, with blood transfusions suspension and Blakemore tube removal. At 6 months, regular TIPS patency at colour Doppler and no rebleeding episodes were recorded. To our knowledge, whilst coils are routinely used for varices embolisation, non-adhesive liquid embolic agents have been never mentioned. Liquid embolic agents seem to provide a stable plug strengthening the embolising action of the coils. Further studies involving a cohort of patients with long-term follow-up will be necessary to confirm whether this association can be more effective than coils alone in gastroesophageal varices embolisation.