bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Features of Graves' Ophthalmopathy and Impact of Enalapril on the Course of Mild Graves’ Ophthalmopathy: A Pilot Study
Authors: Ataabadi Ghazal , Dabbaghmanesh Mohammad H. , Owji Naser , Bakhshayeshkaram Marzieh , Montazeri-Najafabady Nima 
Published: January 2020

Background:Inflammation, oxidative stress, and adipogenesis are associated with Graves’ ophthalmopathy (GO) progression.Objective:We conducted a pilot study to investigate the effect of Enalapril on patients with mild ophthalmopathy.Method:Based on the comprehensive eye examination, 12 patients with mild ophthalmopathy were selected from referred Graves’ patients and treated with Enalapril (5 mg daily) for 6 months. Clinical and ophthalmological examination [IOP (Intraocular Pressure), vision, Margin reflex distance and exophthalmia measurement, CAS (clinical activity score) and VISA [V (vision); I (inflammation/ congestion); S (strabismus/motility restriction); and A (appearance/exposure] score assessment) was performed at the beginning, 3 months and 6 months of the study period. Quality of life was also evaluated using a standard questionnaire.Results:Mean exophthalmia at the first visit was 18.75 ± 2.39, 3 months later 18.53 ± 2.39 and 6 months later was 17.92 ± 2.31, respectively. Mean CAS was 0.71 ± 0.82 (first visit), 0.57 ± 0.54 (3 months) and 0.14 ± 0.36 (6 months), respectively. Mean Margin reflex distance was 9.09 ± 4.36 (first visit) and 9.60 ± 4.40 (6 months), respectively. There were significant differences in the case of exophthalmia (P=0.002), CAS (P=0.006), and Margin reflex distance (P=0.029) between the first visit and 6 months after treatment. The difference between the score of quality of life in patients with GO after 6 months of follow up was statistically significant (P = 0.006).Conclusion:Our results showed that Enalapril treatment could ameliorate the clinical course of GO according to the ophthalmologic examinations and subjective parameters of disease progression. However, further studies should be performed to determine the efficacy of Enalapril in Graves’ ophthalmopathy treatment.
Sequence and Functional Variation in the HIV-1 Rev Regulatory Axis
Authors: Jackson Patrick E.H. , Dzhivhuho Godfrey , Rekosh David , Hammarskjold Marie-Louise 
Published: January 2020

Background:
To complete its replication cycle, HIV-1 requires the nucleocytoplasmic
export of intron-containing viral mRNAs. This process is ordinarily restricted by the cell, but HIV
overcomes the block by means of a viral protein, Rev, and an RNA secondary structure found in all
unspliced and incompletely spliced viral mRNAs called the Rev Response Element (RRE). In vivo
activity of the Rev-RRE axis requires Rev binding to the RRE, oligomerization of Rev to form a
competent ribonucleoprotein complex, and recruitment of cellular factors including Crm1 and
RanGTP in order to export the targeted transcript. Sequence variability is observed among primary
isolates in both Rev and the RRE, and the activity of both can be modulated through relatively small
sequence changes. Primary isolates show differences in Rev-RRE activity and a few studies have
found a correlation between lower Rev-RRE activity and slower progression of clinical disease.
Lower Rev-RRE activity has also been associated with the evasion of cytotoxic T lymphocyte mediated
killing.

Conclusions:
The HIV-1 Rev-RRE regulatory axis is an understudied mechanism by which viral adaptation
to diverse immune milieus may take place. There is evidence that this adaptation plays a
role in HIV pathogenesis, particularly in immune evasion and latency, but further studies with larger
sample sizes are warranted.
The Effect of Treatment and Bone Metabolic Factors on Fracture Incidence in Patients with Thalassemia-Induced Osteoporosis: An Observational Study
Authors: Tsartsalis Athanasios N. , Lambrou George I. , Vlachou Eugenia , Samartzi Athanasia , Chrousos George P. , Kanaka-Gantenbein Christina , Kattamis Antonis 
Published: January 2020

Thalassemia Major (TM) is a hereditary disease caused by defective globin synthesis. Because of the significant increase in life expectancy, these patients suffer from various health conditions, including endocrinopathies and low bone mineral density.Aim:The aim of the present study was to evaluate the fracture incidence regarding the markers of bone metabolism, bone mineral density and treatment of osteoporosis as well as treatment of comorbidities.Methods:Sixty-four patients with TM (32 men and 32 women) participated in a cross-sectional study design. The patients were recruited from “Aghia Sofia” Children’s Hospital and evaluated using dual-energy X-ray absorptiometry (DXA) of the lumbar spine and femoral neck and with markers of bone remodeling including receptor activator of nuclear factor kappa-Β ligand (RANKL), osteoprotegerin (OPG), C-terminal telopeptide (CTX), and sclerostin.Results:The statistical analysis of markers of bone metabolism in relation to fractures revealed no statistical significance. However, statistical analysis of bone mineral density and markers of bone metabolism in relation to fractures was also not significant.Conclusions:In TM patients, fractures are not related to bone mineral density. Maybe some other conditions are the cause, haemosidirosis, drugs, comorbid conditions.
Damping of the track horizontal, transversal vibrations
Authors: Bel’kov V. M. 
Published: January 2020

Knowledge of the oscillation process nature in horizontal plane across the track allows selecting the way of damping for reducing decrease of strength properties of polymer gaskets, rails, sleepers and earthworks under effect of horizontal vibrodynamic loads occurring during the rolling stock movement. Maximum horizontal deformation of polymer gaskets across the track does not exceed 10% therefore stress and deformation of polymer material can be done using the Hooke’s law.This is the first systematization of formulae for calculation of polymer gaskets, as well as the first resolution of the task when not pure shear takes place under effect of tangential stresses with simultaneous effect of vertical load. Damping coefficient of polyurethane gaskets is the same as for rubber gaskets; however, their service life is 2.5 times longer.Based on the presented physical mesomechanics it is demonstrated regarding the surface layer of two metal bodies contact under significant load that the surface mesolayer has damping properties, and vibrating oscillations occurring in the truck wheels when rolling stock moves on the rails will be reflected from the contact pad. The process of wheel and rail sliding in transversal direction is accompanied with increase of the total rolling friction and noise, elevated wear and tear of rails and wheel rims. In order to reduce transversal deformations and amplitude of the rails and sleepers torsion oscillations during rolling movement it is proposed to change the shape of polyurethane gaskets. Gaskets with variable thickness will more effectively reflect the shear transversal oscillating waves and reduce transversal forces.
DETERMINATION OF EARTHQUAKE FOCUS COORDINATES USING THE CASSINI OVAL METHOD WITH SECOND- AND FOURTH-ORDER HYPERBOLA FIGURES
Authors: Shakhtarin B. I. , Aslanov T. G. , Tetakaev U. R. 
Published: January 2020

Objectives. To study the dependencies obtained when determining the coordinates of an earthquake hypocentre using the figures of fourth and second orders.Method. A comparative analysis of determining the coordinates of the earthquake focus using the Cassini oval method, both taking errors in the readings of seismic sensors into account the and ignoring them, is presented.Result. A new method is proposed for determining the coordinates of the earthquake hypocentre, which uses the fourth-order figure, the Cassini oval, in the calculations. A graph is obtained for the distribution of errors in determining the coordinates of the earthquake focus (using the Cassini oval) depending on the relative position of two seismic sensors with different values of their errors in determining the difference in travel times of seismic waves.Conclusion. Since the calculation results are independent of the error sign in determining the difference in the arrival times of seismic waves, the method is suitable for the initial determination of the coordinates of the earthquake hypocentre as well as for comparison with the results of other methods for identifying the error sign.
DECISION-MAKING MODELLING IN A BUILDING ORGANIZATION MANAGING
Authors: Aigumov T. G. , Melekhin V. B. 
Published: January 2020

Objectives. The aim of the work is to develop a situational decision-making model that provides effective management of the activities of large construction engineering organisations under the unstable conditions of the economic environment.Method. The research methods are based on the application of the methodological foundations of situational management and the principles of processing expert data using the mathematical apparatus of fuzzy sets.Results. A method for managing the activities of a construction engineering organisation under an unstable economic environment is proposed. Logical-transformational rules for deriving an information-analytical model of situational management and decision support under conditions of uncertainty are developed. The necessary conditions for the effective use of various logical-transformational inference rules and the need for an organisational management transition to multi-step situational management of the construction engineering organisation are defined.Conclusion. The results of the study allow the effective management of various types of activities of a large construction engineering organisation to be carried out in an unstable economic environment (i.e. under the unstable conditions of the contemporary market).
COMPUTER SCIENCE, COMPUTER ENGINEERING AND MANAGEMENT SYNTHESISING THE MODEL OF THE PREDICTIVE MAINTENANCE OF ATMOSPHERIC PIPE STILL
Authors: Gebel E. S. , Ibatullin A. A. , Peshko M. S. , Gudinov V. N. 
Published: January 2020

Objectives. The aim of the study is to develop a model of a predictive maintenance system allowing the output parameters of a high-capacity distillation unit to be stabilised.Method. The problem of controlling the collection of oil products of a given fractional composition can be reduced to the task of controlling the temperature regime at draw-off trays. In this case, temperature control tasks are considered as control actions. In order to implement the proposed control principle, a mathematical model was constructed allowing the oil fraction content to be converted to directly controlled temperatures.Results. Based on the analysis of the technological process and design features of the atmospheric distillation column, the vectors of maintaining and disturbing actions are determined along with the optimisation criterion for the maintenance problem. In order to improve the dynamic characteristics of the control object, oil product quality parameters are introduced into the predictive maintenance model along with the supplementation of existing control loops with intermediate parameters.Conclusion. An analysis of the structural features of the atmospheric pipe still and the existing approach to the distillation column maintenance reveals certain disadvantages associated with the lack of operational quality control of the collected oil products, as well as the need to expand the list of stabilised technological parameters in order to optimise the technological process. It is shown that in order to switch to the proposed maintenance approach, it is necessary to develop a static model reflecting the dependency of the potential yield of the required fractions on the raw material composition along with a dynamic model in the form of a multi-parameter optimisation problem.
Bahamas National Implementation Project: Proposal for Sustainability of an Evidence-based HIV Prevention Intervention in a School Setting
Authors: Wang Bo , Deveaux Lynette , Lunn Sonja , Dinaj-Koci Veronica , Ghosh Samiran , Li Xiaoming , Marshall Sharon , Rolle Glenda , Forbes Nikkiah , Stanton Bonita 
Published: January 2020

Background
Sustained implementation of school-based prevention programs is low. Effective strategies are needed to enhance both high-level implementation fidelity and sustainability of prevention programs.

Objective
This proposed study aims to determine if the provision of either biweekly monitoring and feedback and site-based assistance and mentorship or both to at-risk and moderate-performing teachers with monitoring through an enhanced decision-making platform by the Ministry of Education (MOE) and Ministry of Health (MOH) based on the real-time implementation data will increase national implementation fidelity and result in sustained implementation over time.

Methods
This study will target government schools including 200 grade 6 teachers in 80 primary schools and 100 junior/middle high school teachers (and their classes) on 12 Bahamian islands. Teacher and school coordinator training will be conducted by the MOE in year 1, followed by an optimization trial among teachers in the capital island. Informed by these results, an implementation intervention will be conducted to train using different levels of educational intensity all at-risk and moderate-performing teachers. Subsequently selected training and implementation strategies will be evaluated for the national implementation of Focus on Youth in the Caribbean and Caribbean Informed Parents and Children Together in years 2 to 5.

Results
It is hypothesized that a more intensive training and supervision program for at-risk and moderate-performing teachers will enhance their implementation fidelity to the average level of the high-performing group (85%), an HIV prevention program delivered at the national level can be implemented with fidelity in grade 6 and sustained over time (monitored annually), and student outcomes will continue to be highly correlated with implementation fidelity and be sustained over time (assessed annually through grade 9). The proposed study is funded by the National Institute of Child Health and Human Development from August 1, 2018, through May 31, 2023.

Conclusions
The study will explore several theory-driven implementation strategies to increase sustained teacher implementation fidelity and thereby increase the general public health impact of evidence-based interventions. The proposed project has potential to make significant contributions to advancing school-based HIV prevention research and implementation science and serve as a global model for the Fast Track strategy.

International Registered Report Identifier (IRRID)
PRR1-10.2196/14816
Self-Care Monitoring of Heart Failure Symptoms and Lung Impedance at Home Following Hospital Discharge: Longitudinal Study
Authors: Aamodt Ina Thon , Lycholip Edita , Celutkiene Jelena , von Lueder Thomas , Atar Dan , Falk Ragnhild Sørum , Hellesø Ragnhild , Jaarsma Tiny , Strömberg Anna , Lie Irene 
Published: January 2020

Background
Self-care is key to the daily management of chronic heart failure (HF). After discharge from hospital, patients may struggle to recognize and respond to worsening HF symptoms. Failure to monitor and respond to HF symptoms may lead to unnecessary hospitalizations.

Objective
This study aimed to (1) determine the feasibility of lung impedance measurements and a symptom diary to monitor HF symptoms daily at home for 30 days following hospital discharge and (2) determine daily changes in HF symptoms of pulmonary edema, lung impedance measurements, and if self-care behavior improves over time when patients use these self-care monitoring tools.

Methods
This study used a prospective longitudinal design including patients from cardiology wards in 2 university hospitals—one in Norway and one in Lithuania. Data on HF symptoms and pulmonary edema were collected from 10 participants (mean age 64.5 years; 90% (9/10) male) with severe HF (New York Heart Association classes III and IV) who were discharged home after being hospitalized for an HF condition. HF symptoms were self-reported using the Memorial Symptom Assessment Scale for Heart Failure. Pulmonary edema was measured by participants using a noninvasive lung impedance monitor, the CardioSet Edema Guard Monitor. Informal caregivers aided the participants with the noninvasive measurements.

Results
The prevalence and burden of shortness of breath varied from participants experiencing them daily to never, whereas lung impedance measurements varied for individual participants and the group participants, as a whole. Self-care behavior score improved significantly (P=.007) from a median of 56 (IQR range 22-75) at discharge to a median of 81 (IQR range 72-98) 30 days later.

Conclusions
Noninvasive measurement of lung impedance daily and the use of a symptom diary were feasible at home for 30 days in HF patients. Self-care behavior significantly improved after 30 days of using a symptom diary and measuring lung impedance at home. Further research is needed to determine if daily self-care monitoring of HF signs and symptoms, combined with daily lung impedance measurements, may reduce hospital readmissions.
Protocol For An Adjuvant Alpha-Fetoprotein-Derived Peptide After Transarterial Chemoembolization in Patients With Hepatocellular Carcinoma: Safety Study
Authors: Nomura Akihiro , Terashima Takeshi , Mizukoshi Eishiro , Kitahara Masaaki , Murayama Toshinori , Kaneko Shuichi 
Published: January 2020

Background
Hepatocellular carcinoma (HCC) is a worldwide health concern because of a continued increase in cases globally; furthermore, the prognosis for patients with HCC remains poor. Transarterial chemoembolization (TACE) has been established as the standard of care for the intermediate stage of HCC; however, no therapeutic agents are available to reduce the high rate of recurrence.

Objective
This study aims to evaluate the safety of alpha-fetoprotein (AFP)-derived peptides for patients with HCC post-TACE.

Methods
This will be an open-label, single-arm, multicenter study to evaluate the safety of AFP-derived peptides (AFP 357 and AFP 403), which contain histocompatibility antigen-A24-restricted cytotoxic T lymphocyte epitopes from tumor antigens expressed in HCC and is recognized at a high rate by lymphocytes in patients with HCC. Protocol treatment will consist of six courses of the subcutaneous administration of 3 mg each of AFP 357 and AFP 403. A total of 14 patients will be included in this study, the first 6 as a main analysis target group and an additional 8 as an extended cohort from three institutions in Japan. The primary endpoint will be the occurrence of serious adverse events (safety profile). The secondary endpoints will include time to progression, overall survival, completion rate, and adverse events (efficacy profile).

Results
We have recruited 14 patients with HCC as of December 2019. The final follow-up will be completed by March 2020.

Conclusions
In this study, we will evaluate the safety profile of AFP-derived peptides for patients with HCC post-TACE. We believe that this study will provide useful information and will help to design a subsequent phase II trial based on the results.

Trial Registration
Japan Registry of Clinical Trials jRCTs041180155; https://jrct.niph.go.jp/latest-detail/jRCTs041180155

International Registered Report Identifier (IRRID)
DERR1-10.2196/17082
MENGUAK KEPATUHAN WAJIB PAJAK DALAM PEMUNGUTAN PPH PASAL 23 ATAS SEWA KENDARAAN(Studi Kasus Pada KPP Pratama Pamekasan)”
Authors: Syakroni Muhammad , Norsain Norsain 
Published: January 2020

Pajak merupakan salah satu sumber penerimaan negara yang diharapkan dapat mengurangi ketergantungan negara kita terhadap hutang luar negeri.”Sektor pajak dianggap pilihan yang paling tepat karena jumlahnya relatif stabil dan masyarakat dapat berpartisipasi secara aktif dalam pembiayaan pembangunan. Pajak Penghasilan merupakan salah satu penopang utama dalam penerimaan pajak,”Salah satu pajak penghasilan tersebut adalah PPh Pasal 23. Usaha rental mobil termasuk pada PPh 23 tersebut. Penelitian ini bertujuan untuk mengetahui tingkat kepatuhan wajib pajak pada pemilik usaha rental mobil sebagai objek pajak PPh 23. Jenis penelitian ini penelitian kualitatif yang menggunakan data primer seperti wawancara, dengan informan. Teknik pengumpulan datadilakukan menggunakan teknik observasi, wawancara, dan dokumentasi. Uji keabsahan data menggunakan Trianggulasi data. Sedangkan alat analisis data yang digunakan melalui reduksi, penyajian data dan penarikan kesimpulan. Penelitian ini dilakukan pada KPP Pratama Pamekasan dimana penulis menggunakan studi kasus terhadap penyelesaian skripsi ini. Berdasarkan hasil penelitian dan pembahasan dapat disimpulkan bahwa kepatuhan wajib pajak oleh pemilik usaha rental mobil masih sangat rendah, dimana hal itu disebabkan oleh 3 faktor yaitu minimnya atau kurangnya pengetatahuan oleh wajib pajak dan legalitas usaha serta tidak adanya sosialisasi oleh petugas pajak terhadap pemilik usaha rental mobil sebagai objek pajak PPh Pasal 23.”
THE INFLUENCE OF INTEREST RATE, MONEY CIRCULATION, INFLATION, AND CPI AGAINST EXPORT AND IMPORT IN INDONESIA 2012-2018
Authors: Sumantri Fazhar , Latifah Umi 
Published: January 2020

Indonesia’s economic growth can no longer depends on internal trade only but needs to depend on the export and import with the global market, thus macroeconomic influence towards export and import needs further research.Thus, this research focuses on the effect of multiple macroeconomic variables which are the rate of loans, money supply, inflation and consumer price index towards export and import in Indonesia. The data used in this research are secondary data acquired from BPS, BI and the Ministry of Trade during the periode of 2012-2018, which are analyzed using the classic assumption tests (normality test, autocorrelation test, heteroscedasticity test, and multicollinearity test) followed by the multiple regression analysis. Based on the F test we concluded that all the dependent variables are simultaneously effecting both import and export, while the T test shows that only the Consumer Price Index does not have any effect towards both import and export while the other variables effect both import and export, this signifies that Consumer Price Index does not need to be considered in analyzing and forecasting of both import and export.
Pelatihan Pembuatan Septic Tank Sehat Sebagai Upaya Meningkatkan Sanitasi Di Desa Lueng Baro Kecamatan Suka Makmue Kabupaten Nagan Raya
Authors: Safriani Meylis , Putri Enda Silvia 
Published: January 2020

Salah satu desa yang terdapat di Kecamatan Suka Makmue, Kabupaten Nagan Raya adalah Desa Lueng Baro. Desa ini masih termasuk rawan sanitasi. Hasil studi awal menunjukkan bahwa masyarakat di desa tersebut belum memiliki sarana sanitasi yang baik. Kebiasaan masyarakat di desa tersebut masih membuang air besar di berbagai tempat seperti saluran irigasi, saluran drainase, alue (anak sungai), dan bahkan ada yang membuang air besar di halaman kosong di belakang rumah mereka. Bagi masyarakat yang telah memiliki jamban, namun belum memiliki tangki septik yang memenuhi standar seperti lantai pada tangki septik (septic tank) tidak di cor, sehingga air limbah buangan jamban dapat menyerap ke dalam tanah. Pada pengabdian ini diperkenalkan bagaimana cara membangun tangki septik (septic tank) sehat sehingga air limbah dari jamban dapat dibuang secara aman ke drainase. Pemberian materi kepada tim mitra dilakukan melalui kegiatan pelatihan oleh tim pengabdian dari Universitas Teuku Umar Meulaboh. Pelaksanaan kegiatan pengabdian tentang pembuatan tangki septik sehat telah dilakukan di Desa Lueng Baroe. Pelatihan yang diberikan terdiri dari langkah-langkah membuat biofilter dari botol plastik bekas sebagai bahan pengganti biolfilter sarang tawon dan membuat cor an lantai dan dinding tangki septik yang kedap air. Pada desa ini di dusun Cot Rundeng telah dibangun tangki septik sehat yang mana respon dari mitra sangat positif, dan antusias. Mitra mau menerima inovasi teknologi yang diberikan serta memiliki minat yang tinggi dan bersedia untuk menerapkan teknologi yang telah diberikan.