bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autophagy and its role in regeneration and remodeling within invertebrate
Authors: Song Qian , Liu Hongjin , Zhen Hui , Zhao Bosheng 
Published: September 2020

Abstract
Background
Acting as a cellular cleaner by packaging and transporting defective proteins and organelles to lysosomes for breakdown, autophagic process is involved in the regulation of cell remodeling after cell damage or cell death in both vertebrate and invertebrate. In human, limitations on the regenerative capacity of specific tissues and organs make it difficult to recover from diseases. Comprehensive understanding on its mechanism within invertebrate have strong potential provide helpful information for challenging these diseases.

Method
In this study, recent findings on the autophagy function in three invertebrates including planarian, hydra and leech with remarkable regenerative ability were summarized. Furthermore, molecular phylogenetic analyses of DjATGs and HvATGs were performed on these three invertebrates compared to that of Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus and Homo sapiens.

Results
In comparison with Scerevisiae, C elegans, D melanogaster, M musculus and human, our analysis exhibits the following characteristics of autophagy and its function in regeneration within invertebrate. Phylogenetical analysis of ATGs revealed that most autophagy-related genes (ATGs) were highly similar to their homologs in other species, which indicates that autophagy is a highly conservative biological function in both vertebrate and invertebrate. Structurally, almost all the core amino acids necessary for the function of ATG8 in mammal were observed in invertebrate HvATG8s and DjATG8s. For instance, ubiquitin-like domain as a signature structure in each ATG8, was observed in all ATG8s in three invertebrates. Basically, autophagy plays a key role in the regulation of regeneration in planarian. DjATG8-2 and DjATG8-3 associated with mTOR signaling pathway are sophisticated in the invertebrate tissue/organ regeneration. Furthermore, autophagy is involved in the pathway of neutralization of toxic molecules input from blood digestion in the leech.

Conclusions
The recent investigations on autophagy in invertebrate including planarian, hydra and leech suggest that autophagy is evolutionally conserved from yeast to mammals. The fundamental role of its biological function in the invertebrate contributing to the regeneration and maintenance of cellular homeostasis in these three organisms could make tremendous information to confront life threatening diseases in human including cancers and cardiac disorders.
Low-complexity decoding of LDPC codes using reduced-set WBF-based algorithms
Authors: Haddadi Sadjad , Farhang Mahmoud , Derakhtian Mostafa 
Published: September 2020

AbstractWe propose a method to substantially reduce the computational complexity of iterative decoders of low-density parity-check (LDPC) codes which are based on the weighted bit-flipping (WBF) algorithm. In this method, the WBF-based decoders are modified so that the flipping function is calculated only over a reduced set of variable nodes. An explicit expression for the achieved complexity gain is provided and it is shown that for a code of block length N, the decoding complexity is reduced from O(N2) to O(N). Moreover, we derive an upper bound for the difference in the frame error rate of the reduced-set decoders and the original WBF-based decoders, and it is shown that the error performances of the two decoders are essentially the same.
Modeling the effects of contact tracing on COVID-19 transmission
Authors: Traoré Ali , Konané Fourtoua Victorien 
Published: September 2020

AbstractIn this paper, a mathematical model for COVID-19 that involves contact tracing is studied. The contact tracing-induced reproduction number $\mathcal{R}_{q}$

R
q

and equilibrium for the model are determined and stabilities are examined. The global stabilities results are achieved by constructing Lyapunov functions. The contact tracing-induced reproduction number $\mathcal{R}_{q}$

R
q

is compared with the basic reproduction number $\mathcal{R}_{0}$

R
0

for the model in the absence of any intervention to assess the possible benefits of the contact tracing strategy.
A collaborative scheduling strategy for IoV computing resources considering location privacy protection in mobile edge computing environment
Authors: Pang Meiyu , Wang Li , Fang Ningsheng 
Published: September 2020

AbstractThis paper proposes a collaborative scheduling strategy for computing resources of the Internet of vehicles considering location privacy protection in the mobile edge computing environment. Firstly, a multi area multi-user multi MEC server system is designed, in which a MEC server is deployed in each area, and multiple vehicle user equipment in an area can offload computing tasks to MEC servers in different areas by a wireless channel. Then, considering the mobility of users in Internet of vehicles, a vehicle distance prediction based on Kalman filter is proposed to improve the accuracy of vehicle-to-vehicle distance. However, when the vehicle performs the task, it needs to submit the real location, which causes the problem of the location privacy disclosure of vehicle users. Finally, the total cost of communication delay, location privacy of vehicles and energy consumption of all users is formulated as the optimization goal, which take into account the system state, action strategy, reward and punishment function and other factors. Moreover, Double DQN algorithm is used to solve the optimal scheduling strategy for minimizing the total consumption cost of system. Simulation results show that proposed algorithm has the highest computing task completion rate and converges to about 80% after 8000 iterations, and its performance is more ideal compared with other algorithms in terms of system energy cost and task completion rate, which demonstrates the effectiveness of our proposed scheduling strategy.
Same-day antiretroviral treatment (ART) initiation and associated factors among HIV positive people in Northwest Ethiopia: baseline characteristics of prospective cohort
Authors: Moges Nurilign Abebe , Adesina Olubukola Adeponle , Okunlola Micheal A. , Berhane Yemane 
Published: September 2020

AbstractBackgroundDespite a well-established fact that same-day or rapid ART initiation after a positive HIV test result is vital for faster viral suppression and for prevention of further sexual transmissions of HIV, there is a paucity of evidence on the uptake of same-day ART initiation among newly HIV diagnosed people in Northwest, Ethiopia.MethodsA cross-sectional study was conducted between December 1st, 2018 and July 30, 2019. About 759 newly HIV diagnosed adults were recruited from 24 health facilities. Data were collected using interviewer-administered questionnaire. Data were entered using EPI-Data and exported to SPSS and STATA software for further analysis. Bivariate logistic regression was used to select candidate variables atp-value less than 0.25 for multivariate logistic regression. Then adjusted odds ratio with 95% Confidence Interval (CI) at p-value of less than 0.05 was used to declare the statistical associations between the dependent and independent variables.ResultMagnitude of same-day ART initiation was 318 (41.90%)[(95% CI, 38.2–45.20%)]. Factors associated with same-day ART initiation were: Patients resided in West Gojjam Zone were 2.04 times more likely to initiate same-day ART compared to those in Bahir Dar city administration [AOR = 2.04 (1.04–3.97)], patients in the health centers were 3.06 times more likely to initiate same-day ART initiation compared to those in the hospitals [AOR = 3.06 (1.90–4.92)] and Patients who were diagnosed their HIV status at the same health facility where they linked for ART were 2.16 times more likely to initiate ART at the same-day of diagnosis [AOR = 2.16 (91.24–3.74)]. Moreover, patients with no opportunistic infection [AOR = 2.08 (1.04–4.19)] and pregnant women [AOR = 3.97 (1.78–8.87)] were more likely to initiate ART same-day of diagnosis.ConclusionsSame-day ART initiation was low among HIV patients in Ethiopia. Patients attending their treatment at hospitals and those from big city (Bahir Dar) were less likely to initiate same-day ART. Clinical factors such as having opportunistic infections and non-pregnancy status affected the immediate initiation of treatment. HIV positive people who seek care in hospitals and those tested HIV positive from another health facilities in which they did not intend to continue their ART follow-up care need special attention.
Current situation and distribution equality of public health resource in China
Authors: Yao Honghui , Zhan Chaohong , Sha Xinping 
Published: September 2020

Abstract
Background
The public health system has been developed in China for several years while no research explores its distribution. This research aims to describe the variation and equality of public health allocation from 2013 to 2018 and explore the source of inequality.

Methods
Data in this research was obtained from the China Health Statistics Yearbook 2014 to 2019 and the China Statistical Yearbook 2019. Four indicators were chosen in describing the development and current situation of the public health system. Three of them were used to evaluate allocation equality. 31 provinces were categorized into western, middle, and eastern groups based on geographical and economic conditions. Total allocation equality, inter- and intra-difference were all measured by the Theil index.

Results
All indicators showed a stably upwards trend except for the number of public health institutions. The allocation gap of the public health institution per km2 was larger than that per 10,000 capita. Theil index of three indicators continually rose from 2013 to 2018 and the inequality of public health institutions allocation was the highest one. The western region had the highest Theil index in technical personnel and beds allocation. Among the three regions, the western region contributed most to inequality.

Conclusions
The public health workforces and institutions are still under the requirement of the National Medical and Health Service System Plan. From 2013 to 2018, the equality of public health resources stably decreases, which is mainly contributed by the internal difference within the western region. Further research should be done to explore the possible cause of the results. Problems founded in this research should be solved by multisectoral cooperation.
Theoretical background of innovation in services in small and medium-sized enterprises: literature mapping
Authors: de Oliveira Sousa Saymon Ricardo , da Silva Wesley Vieira , da Veiga Claudimar Pereira , Zanini Roselaine Ruviaro 
Published: September 2020

AbstractThe aim of this study was to map the innovation of services in small and medium-sized enterprises, as reported on the Web of Science and SCOPUS databases, using a structured review, involving 121 papers published between 1946 and 2019. There has been an increase in the number of studies in recent years, covering 23 countries on six continents, with the UK representing 48.78% of the studies. Patterns in the use of methods applied in research were identified, as well as a conceptual structure of the field. The main areas of science were finance, marketing, energy, and green engineering. The study makes an original contribution to the literature, highlighting the interest in the expansion of knowledge among the academic community, in addition to enabling a deeper analysis of the relation between the evaluated constructs.
Endothelial glycocalyx shedding in the acute respiratory distress syndrome after flu syndrome
Authors: Benatti Maira Nilson , Fabro Alexandre Todorovic , Miranda Carlos Henrique 
Published: September 2020

Abstract
Background
Scientific evidence indicates that endothelial glycocalyx (EG) shedding contributes to the pathophysiological installation of acute respiratory distress syndrome (ARDS) after bacterial sepsis. The aim was to evaluate the EG shedding in ARDS installation after flu syndrome.

Methods
This cross-sectional study included patients with flu syndrome during the influenza outbreak divided into two groups: patients with and without ARDS. Healthy subjects without flu syndrome were included in a control group. We measured EG damage biomarkers (hyaluronan, syndecan-1) and endothelial cell injury biomarker (soluble thrombomodulin) during the first medical evaluation. Histological assessment of the perimeter of the hyaline membrane and the number of neutrophils infiltrated in the alveolar septum was performed in patients who died.

Results
ARDS group had 30 patients (44 ± 16 years old, 57% men), the non-ARDS group had 36 patients (39 ± 17 years old, 42% men), and the control group had 35 individuals (44 ± 9 years old, 51% men). Hyaluronan levels were significantly higher in the ARDS group than the two groups [31 ng/ml (interquartile range-IQR 12–56) vs. 5 ng/ml (IQR 3–10) vs. 5 ng/ml (IQR 2–8); p < 0.0001]. Hyaluronan levels above 19 ng/ml in patients with flu syndrome were associated with a significant increase in 28-day mortality rate: relative risk (RR): 6.95; (95% confidence interval 1.88–25.67); p = 0.0017. A positive correlation was observed between hyaline membrane perimeter and soluble thrombomodulin levels (r = 0.89; p = 0.05) as well as between the number of neutrophils in the alveolar septum and hyaluronan levels (r = 0.89; p = 0.05).

Conclusions
Evidence of EG shedding was found in ARDS established after flu syndrome.
REC8 suppresses tumor angiogenesis by inhibition of NF-κB-mediated vascular endothelial growth factor expression in gastric cancer cells
Authors: Liu Miao , Xu Wanfu , Su Mingmin , Fan Pingsheng 
Published: September 2020

Abstract
Background
Tumor angiogenesis is an essential event for tumor growth and metastasis. It has been showed that REC8, a component of the meiotic cohesion complex, played a vital role in Epithelial-Mesenchymal Transition (EMT) in gastric cancer. However, the role of REC8 in gastric cancer angiogenesis remains to be identified.

Results
Inhibition of REC8 expression in gastric cancer cells contributed to tumor angiogenesis in the gastric cancer microenvironment. The clinical analysis demonstrated that the loss of REC8 in gastric cancer with enrichment of MVD. Depletion of REC8 expression in gastric cancer cells significantly increased tube formation of human umbilical vein endothelial cells (HUVECs), which is attributed to enhancement of vascular endothelial growth factor (VEGF) secretion caused by REC8 slicing. While addition of neutralizing antibody targeted VEGF into supernatant drastically reversed the effect of REC8 loss in gastric cancer cells on tube formation. Mechanistic analyses indicated that ablation of REC8 promotes nuclear factor-κB (NF-κB) p65 activity and its downstream gene VEGF expression, leading to tube formation.

Conclusions
These results demonstrated a novel REC8 function that suppressed tumor angiogenesis and progression by attenuation of VEGF in gastric cancer microenvironment.
Identification of dental implants using deep learning—pilot study
Authors: Takahashi Toshihito , Nozaki Kazunori , Gonda Tomoya , Mameno Tomoaki , Wada Masahiro , Ikebe Kazunori 
Published: September 2020

Abstract
Background
In some cases, a dentist cannot solve the difficulties a patient has with an implant because the implant system is unknown. Therefore, there is a need for a system for identifying the implant system of a patient from limited data that does not depend on the dentist’s knowledge and experience. The purpose of this study was to identify dental implant systems using a deep learning method.

Methods
A dataset of 1282 panoramic radiograph images with implants were used for deep learning. An object detection algorithm (Yolov3) was used to identify the six implant systems by three manufactures. To implement the algorithm, TensorFlow and Keras deep-learning libraries were used. After training was complete, the true positive (TP) ratio and average precision (AP) of each implant system as well as the mean AP (mAP), and mean intersection over union (mIoU) were calculated to evaluate the performance of the model.

Results
The number of each implant system varied from 240 to 1919. The TP ratio and AP of each implant system varied from 0.50 to 0.82 and from 0.51 to 0.85, respectively. The mAP and mIoU of this model were 0.71 and 0.72, respectively.

Conclusions
The results of this study suggest that implants can be identified from panoramic radiographic images using deep learning-based object detection. This identification system could help dentists as well as patients suffering from implant problems. However, more images of other implant systems will be necessary to increase the learning performance to apply this system in clinical practice.
Assessment of hepatic fibrosis and steatosis by vibration-controlled transient elastography and controlled attenuation parameter versus non-invasive assessment scores in patients with non-alcoholic fatty liver disease
Authors: Mansour Ahmed M. F. , Bayoumy Essam M. , ElGhandour Ahmed M. , El-Talkawy Mohamed Darwish , Badr Sameh M. , Ahmed Ahmed El-Metwally 
Published: September 2020

Abstract
Background
Non-alcoholic fatty liver disease (NAFLD) is regarded as the most common liver disease in the twenty-first century, and a condition leaving individuals at increased risk of extra-hepatic morbidity. Liver biopsy has long been regarded as the gold standard for diagnosis and prognostication of patients with NAFLD. However, due to its invasive nature and potential complications (e.g., bleeding), other methods for non-invasive laboratory and radiological assessment of hepatic steatosis and fibrosis in NAFLD have evolved and include scores such as AST/Platelet Ratio Index (APRI), Fibrosis-4 (FIB-4) score, NAFLD fibrosis score (NFS), and fatty liver index (FLI), in addition to radiological methods such as transient elastography (TE), which is a well-validated non-invasive ultrasound-based technique for assessment of hepatic fibrosis. Recently, novel development of controlled attenuation parameter (CAP) in TE allowed simultaneous assessment of hepatic steatosis. This provided a chance to assess both hepatic fibrosis and steatosis in the same setting and without any unwanted complications. This study aimed at assessing the role of TE and CAP versus other non-invasive assessment scores for liver fibrosis and steatosis in patients with NAFLD.

Results
This study included 90 patients diagnosed with NAFLD based on abdominal ultrasonography, body mass index, and serum liver enzymes. All patients were assessed with TE and non-invasive scores (APRI score, FIB-4 score, NFS, and FLI). There was a highly significant positive correlation between fibrosis and steatosis grades assessed by TE and other non-invasive respective scores. Both TE and CAP achieved acceptable sensitivity and specificity compared to other non-invasive assessment methods.

Conclusions
TE with CAP can be used as a screening method for patients suspected with NAFLD or patients without a clear indication for liver biopsy. CAP allows a non-invasive method of assessment of hepatic steatosis in patients with NAFLD.
Circadian Rhythms and the Gastrointestinal Tract: Relationship to Metabolism and Gut Hormones
Authors: Martchenko Alexandre , Martchenko Sarah E , Biancolin Andrew D , Brubaker Patricia L 
Published: September 2020

Abstract
Circadian rhythms are 24-hour biological rhythms within organisms that have developed over evolutionary time due to predefined environmental changes, mainly the light-dark cycle. Interestingly, metabolic tissues, which are largely responsible for establishing diurnal metabolic homeostasis, have been found to express cell-autonomous clocks that are entrained by food intake. Disruption of the circadian system, as seen in individuals who conduct shift work, confers significant risk for the development of metabolic diseases such as type 2 diabetes and obesity. The gastrointestinal (GI) tract is the first point of contact for ingested nutrients and is thus an essential organ system for metabolic control. This review will focus on the circadian function of the GI tract with a particular emphasis on its role in metabolism through regulation of gut hormone release. First, the circadian molecular clock as well as the organization of the mammalian circadian system is introduced. Next, a brief overview of the structure of the gut as well as the circadian regulation of key functions important in establishing metabolic homeostasis is discussed. Particularly, the focus of the review is centered around secretion of gut hormones; however, other functions of the gut such as barrier integrity and intestinal immunity, as well as digestion and absorption, all of which have relevance to metabolic control will be considered. Finally, we provide insight into the effects of circadian disruption on GI function and discuss chronotherapeutic intervention strategies for mitigating associated metabolic dysfunction.
Digenic Variants in the FGF21 Signaling Pathway Associated with Severe Insulin Resistance and Pseudoacromegaly
Authors: Stone Stephen I , Wegner Daniel J , Wambach Jennifer A , Cole F Sessions , Urano Fumihiko , Ornitz David M 
Published: September 2020

Abstract
Insulin-mediated pseudoacromegaly (IMPA) is a rare disease of unknown etiology. Here we report a 12-year-old female with acanthosis nigricans, hirsutism, and acromegalic features characteristic of IMPA. The subject was noted to have normal growth hormone secretion, with extremely elevated insulin levels. Studies were undertaken to determine a potential genetic etiology for IMPA. The proband and her family members underwent whole exome sequencing. Functional studies were undertaken to validate the pathogenicity of candidate variant alleles. Whole exome sequencing identified monoallelic, predicted deleterious variants in genes that mediate fibroblast growth factor 21 (FGF21) signaling, FGFR1 and KLB, which were inherited in trans from each parent. FGF21 has multiple metabolic functions but no known role in human insulin resistance syndromes. Analysis of the function of the FGFR1 and KLB variants in vitro showed greatly attenuated ERK phosphorylation in response to FGF21, but not FGF2, suggesting that these variants act synergistically to inhibit endocrine FGF21 signaling but not canonical FGF2 signaling. Therefore, digenic variants in FGFR1 and KLB provide a potential explanation for the subject’s severe insulin resistance and may represent a novel category of insulin resistance syndromes related to FGF21.