bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis
Authors: Liang Xiaojuan , Tao Cong , Pan Jianfei , Zhang Lilan , Liu Lulu , Zhao Ying , Fan Yiping , Cao Chunwei , Liu Jiali , Zhang Jin , Lam Sin Man , Shui Guanghou , Jin Wanzhu , Li Wei , Zhao Jianguo , Li Kui , Wang Yanfang 
Published: August 2020

AbstractRNF20, an E3 ligase critical for monoubiquitination of histone H2B at lysine 120 (H2Bub), has been implicated in the regulation of various cellar processes; however, its physiological roles in adipocytes remain poorly characterized. Here, we report that the adipocyte-specific knockout of Rnf20 (ASKO) in mice led to progressive fat loss, organomegaly and hyperinsulinemia. Despite signs of hyperinsulinemia, normal insulin sensitivity and improved glucose tolerance were observed in the young and aged CD-fed ASKO mice. In addition, high-fat diet-fed ASKO mice developed severe liver steatosis. Moreover, we observed that the ASKO mice were extremely sensitive to a cold environment due to decreased expression levels of brown adipose tissue (BAT) selective genes, including uncoupling protein 1 (Ucp1), and impaired mitochondrial functions. Significantly decreased levels of peroxisome proliferator-activated receptor gamma (Pparγ) were observed in the gonadal white adipose tissues (gWAT) from the ASKO mice, suggesting that Rnf20 regulates adipogenesis, at least in part, through Pparγ. Rosiglitazone-treated ASKO mice exhibited increased fat mass compared to that of the non-treated ASKO mice. Collectively, our results illustrate the critical role of RNF20 in control of white and brown adipose tissue development and physiological function.
Enhanced Pseudo-Capacitive Contributions to High-Performance Sodium Storage in TiO2/C Nanofibers via Double Effects of Sulfur Modification
Authors: Zhang Yan , Huang Yuanye , Srot Vesna , van Aken Peter A. , Maier Joachim , Yu Yan 
Published: August 2020

AbstractPseudo-capacitive mechanisms can provide higher energy densities than electrical double-layer capacitors while being faster than bulk storage mechanisms. Usually, they suffer from low intrinsic electronic and ion conductivities of the active materials. Here, taking advantage of the combination of TiS2 decoration, sulfur doping, and a nanometer-sized structure, as-spun TiO2/C nanofiber composites are developed that enable rapid transport of sodium ions and electrons, and exhibit enhanced pseudo-capacitively dominated capacities. At a scan rate of 0.5 mV s−1, a high pseudo-capacitive contribution (76% of the total storage) is obtained for the S-doped TiS2/TiO2/C electrode (termed as TiS2/S-TiO2/C). Such enhanced pseudo-capacitive activity allows rapid chemical kinetics and significantly improves the high-rate sodium storage performance of TiO2. The TiS2/S-TiO2/C composite electrode delivers a high capacity of 114 mAh g−1 at a current density of 5000 mA g−1. The capacity maintains at high level (161 mAh g−1) even after 1500 cycles and is still characterized by 58 mAh g−1 at the extreme condition of 10,000 mA g−1 after 10,000 cycles.
The Development of Aerobic and Anaerobic Fitness with Reference to Youth Athletes
Authors: Armstrong Neil , Welsman Jo 
Published: August 2020

Abstract
Purpose
To challenge current conventions in paediatric sport science and use data from recent longitudinal studies to elucidate the development of aerobic and anaerobic fitness, with reference to youth athletes.

Methods
(1) To critically review the traditional practice of ratio scaling physiological variables with body mass and, (2) to use multiplicative allometric models of longitudinal data, founded on 1053 (550 from boys) determinations of 10–17-year-olds’ peak oxygen uptake ($$ {{\text{V}}\text{O}}_{2} $$

VO

2

) and 763 (405 from boys) determinations of 11–17-year-olds’ peak power output (PP) and mean power output (MP), to investigate the development of aerobic and anaerobic fitness in youth.

Results
The statistical assumptions underpinning ratio scaling of physiological variables in youth are seldom met. Multiplicative allometric modelling of longitudinal data has demonstrated that fat free mass (FFM) acting as a surrogate for active muscle mass, is the most powerful morphological influence on PP, MP, and peak $$ {{\text{V}}\text{O}}_{2} $$

VO

2

. With FFM appropriately controlled for, age effects remain significant but additional, independent effects of maturity status on anaerobic and aerobic fitness are negated.

Conclusions
Ratio scaling of physiological variables with body mass is fallacious, confounds interpretation of the development of anaerobic and aerobic fitness, and misleads fitness comparisons within and across youth sports. Rigorous evaluation of the development of anaerobic and aerobic fitness in youth requires longitudinal analyses of sex-specific, concurrent changes in age- and maturation-driven morphological covariates. Age and maturation-driven changes in FFM are essential considerations when evaluating the physiological development of youth athletes.
Making behavioral science integral to climate science and action
Authors: FISCHHOFF BARUCH 
Published: August 2020

AbstractThe behavioral sciences were there at the beginning of the systematic study of climate change. However, in the ensuing quarter century, they largely faded from view, during which time public discourse and policy evolved without them. That disengagement and the recent reengagement suggest lessons for the future role of the behavioral sciences in climate science and policy. Looking forward, the greatest promise lies in projects that make behavioral science integral to climate science by: (1) translating behavioral results into the quantitative estimates that climate analyses need; (2) making climate research more relevant to climate-related decisions; and (3) treating the analytical process as a behavioral enterprise, potentially subject to imperfection and improvement. Such collaborations could afford the behavioral sciences more central roles in setting climate-related policies, as well as implementing them. They require, and may motivate, changes in academic priorities.
Tracing the modes of China's revisionism in the Indo-Pacific: a comparison with pre-1941 Shōwa Japan
Authors: Natalizia Gabriele , Termine Lorenzo 
Published: August 2020

AbstractThe People's Republic of China (PRC) has irrefutably reached ‘great power’ status. As a consequence, most studies argue that it has adopted a revisionist posture towards the US-led international order. However, this image tells us little about Beijing's revisionist strategy, particularly whether it is revolutionary or incremental and what this implies in terms of actual policies. The current article posits that the PRC is behaving as an incremental revisionist and aims at tracing its modes. To verify this hypothesis, the analysis focuses on Beijing's policies towards its regional security order. In this light, it diachronically compares post-Cold War China (1989–2019) with the paradigmatic case of a revolutionary revisionist in the Indo-Pacific region: Shōwa Japan in the Interwar period (1926–1941). The findings offer a helpful contribution to the literature, providing the foundation for a more nuanced theoretical definition of incremental revisionism.
Effects of maternal supplementation with fully oxidised β-carotene on the reproductive performance and immune response of sows, as well as the growth performance of nursing piglets
Authors: Chen Jun , Chen Jiaming , Zhang Yinzhi , Lv Yantao , Qiao Hanzhen , Tian Min , Cheng Lin , Chen Fang , Zhang Shihai , Guan Wutai 
Published: August 2020

AbstractThe present study was conducted to evaluate the impact of dietary fully oxidised β-carotene (OxBC, C40H60O15) supplementation during the perinatal period on immune status and productivity in a sow model. At day 85 of pregnancy, 150 sows were allocated to one of three dietary treatments with fifty sows per treatment. The three experimental diets were supplemented with 0, 4 or 8 mg/kg OxBC in the basal diet. The feeding trial was conducted from gestation day 85 until day 21 of lactation. Dietary OxBC supplementation greatly enhanced colostrum IgM, IgA and IgG levels, and the IgM and IgG content of 14-d milk. Dietary OxBC supplementation decreased the TNF-α and IL-8 levels in colostrum, as well as the TNF-α and IL-18 levels in 14-d milk. There was also a tendency towards an increase in the soluble CD14 level in 14-d milk. Although dietary treatments did not affect average daily feed intake nor backfat thickness loss during lactation, dietary OxBC supplementation tended to enhance litter weight and individual piglet weight at weaning. There was a trend towards increased lactose concentration in 14-d milk with increasing dietary OxBC. It is concluded that dietary supplementation with OxBC during the perinatal period enhances the lactose concentration of sow milk and the immune status of sows, which is reflected by improved cytokine status and immunoglobulin concentrations in colostrum and milk, and thus tending to increase litter weight and individual piglet weight at weaning. The results also provide a scientific nutritional reference for perinatal mothers due to the biological similarity between pigs and humans.
Consumption of ultra-processed foods and health status: a systematic review and meta-analysis
Authors: Pagliai G. , Dinu M. , Madarena M. P. , Bonaccio M. , Iacoviello L. , Sofi F. 
Published: August 2020

AbstractIncreasing evidence suggests that high consumption of ultra-processed foods (UPF) is associated with an increase in non-communicable diseases, overweight and obesity. The present study systematically reviewed all observational studies that investigated the association between UPF consumption and health status. A comprehensive search of MEDLINE, Embase, Scopus, Web of Science and Google Scholar was conducted, and reference lists of included articles were checked. Only cross-sectional and prospective cohort studies were included. At the end of the selection process, twenty-three studies (ten cross-sectional and thirteen prospective cohort studies) were included in the systematic review. As regards the cross-sectional studies, the highest UPF consumption was associated with a significant increase in the risk of overweight/obesity (+39 %), high waist circumference (+39 %), low HDL-cholesterol levels (+102 %) and the metabolic syndrome (+79 %), while no significant associations with hypertension, hyperglycaemia or hypertriacylglycerolaemia were observed. For prospective cohort studies evaluating a total population of 183 491 participants followed for a period ranging from 3·5 to 19 years, highest UPF consumption was found to be associated with increased risk of all-cause mortality in five studies (risk ratio (RR) 1·25, 95 % CI 1·14, 1·37;P< 0·00001), increased risk of CVD in three studies (RR 1·29, 95 % CI 1·12, 1·48;P= 0·0003), cerebrovascular disease in two studies (RR 1·34, 95 % CI 1·07, 1·68;P= 0·01) and depression in two studies (RR 1·20, 95 % CI 1·03, 1·40;P= 0·02). In conclusion, increased UPF consumption was associated, although in a limited number of studies, with a worse cardiometabolic risk profile and a higher risk of CVD, cerebrovascular disease, depression and all-cause mortality.
Supplementing grass-based cattle feeds with legume leaves and its effects on manure quality and value as a soil improver for an Anthropic Ferralsol in Rwanda
Authors: Mukangango Marguerite , Nduwamungu Jean , Naramabuye Francois Xavier , Nyberg Gert , Dahlin A. Sigrun 
Published: August 2020

AbstractCombined use of lime, animal manure and inorganic fertilisers is effective in replenishing the fertility of degraded acid soils. However, many smallholder farmers lack access to sufficient amounts of these inputs to improve the fertility and reduce the aluminium toxicity of Ferralsols. Organic manures are available but often have low nutrient content, which limits their ability to supply nutrients to soils. In a two-factor field experiment over four seasons on an Anthropic Ferralsol in Southern Province, Rwanda, we assessed (i) the effect of cattle manure on soil properties at a reduced rate affordable to smallholder farmers compared with that of NPK fertiliser applied, with and without lime also at a reduced rate, and (ii) the effect of supplementing grass in a basal cattle diet with legume leaves on manure quality and its effect on soil properties. Manure from cattle fed only the grass Chloris gayana (grass-only manure) and from cattle fed C. gayana supplemented with Acacia angustissima leaves (grass+legume manure) was applied at 5 t dry matter ha-1 (25% of the recommended rate) at the beginning of each growing season. NPK was applied as split doses supplying a total rate of 70 kg N ha-1. Lime was applied annually at a rate of 2.0 t CaO ha-1, which was 25% of the rate required to neutralise total acidity at the site. All amendments were applied only to the soil surrounding the maize plants (planting stations), which is estimated at 25% of the plot area. Maize stover was left on plots after harvest and planting stations were retained over all growing seasons. All treatments altered soil properties at the planting stations. Lime generally increased pH but there was no significant difference between lime plus manure treatments and non-limed manure treatments. Soil organic carbon concentration and cation exchange capacity were higher in manure and NPK treatments than in non-fertilised treatments. The manure treatment increased soil water-holding capacity compared with the NPK and non-fertilised treatments. There was no significant difference in total N, Ca2+, Mg2+ and K+ between the NPK and manure treatments. Micro-dosing animal manure can thus replace mineral fertiliser plus lime for soil fertility replenishment in smallholder farming. Grass+legume manure contained higher concentrations of total N, Ca, Mg, K and Na than grass-only manure, but its effect on soil properties did not differ significantly from that of grass-only manure.
A creaturely wisdom: Suffering, compassion and grace in Isaac of Nineveh
Authors: Duca Valentina 
Published: August 2020

AbstractIn the writings of Isaac of Nineveh, a seventh-century East Syriac solitary, one finds a profound compassion for every created being, including wild animals, heretics and demons. This article shows that this compassionate attitude towards external negative entities is rooted in the creature's relationship with its own condition of vulnerability. This vulnerability is distinctive of the human condition. Isaac conceives of the passions as attempts to remove this ontological condition, proposing that one can instead learn to deal with it and to ‘take it on’. This occurs through a demanding exercise of relationship with one's suffering self, and only once this relationship has been discovered does grace reveal itself to the creature. Grace, therefore, emerges from Isaac's writings as something that never removes one's creaturely poverty, but reveals itself only to the person who has the courage to experience, ‘bear’ and ‘take on’ this poverty.
Reliable knowledge, true freedom: The remnant of the analogia temporalis in the theology of Robert Jenson and its implications for the epistemology–freedom debate
Authors: Garton Alexander D. 
Published: August 2020

AbstractWhile Karl Barth balances the reliability of revelation with divine counterfactual freedom through the analogia temporalis, Robert Jenson rejects this form of analogy, arguing that it posits an unknowable reality of God behind revelation. He instead transposes metaphysics into narratological terms, arguing that this secures the reliability of revelation and divine freedom, since it means God is future to (and so undetermined by) events in time. This metric for divine freedom cannot, however, replace counterfactual possibility; hence, the analogia temporalis (presupposed in counterfactuals) re-emerges in Jenson's theology. This form of analogy is essential in balancing the reliability of revelation with divine freedom.
Transmission of viral pathogens in a social network of university students: the eX-FLU study
Authors: Zivich P.N. , Eisenberg M.C. , Monto A.S. , Uzicanin A. , Baric R. S. , Sheahan T. P. , Rainey J. J. , Gao H. , Aiello A. E. 
Published: August 2020

Abstract
Previous research on respiratory infection transmission among university students has primarily focused on influenza. In this study, we explore potential transmission events for multiple respiratory pathogens in a social contact network of university students. University students residing in on-campus housing (n = 590) were followed for the development of influenza-like illness for 10-weeks during the 2012–13 influenza season. A contact network was built using weekly self-reported contacts, class schedules, and housing information. We considered a transmission event to have occurred if students were positive for the same pathogen and had a network connection within a 14-day period. Transmitters were individuals who had onset date prior to their infected social contact. Throat and nasal samples were analysed for multiple viruses by RT-PCR. Five viruses were involved in 18 transmission events (influenza A, parainfluenza virus 3, rhinovirus, coronavirus NL63, respiratory syncytial virus). Transmitters had higher numbers of co-infections (67%). Identified transmission events had contacts reported in small classes (33%), dormitory common areas (22%) and dormitory rooms (17%). These results suggest that targeting person-to-person interactions, through measures such as isolation and quarantine, could reduce transmission of respiratory infections on campus.
Resilience in the aftermath of hurricanes: Fluctuations in a Critically Endangered population of West Indian WoodpeckersMelanerpes superciliaris nyeanusover two decades
Authors: AKRESH MICHAEL E. , ASKINS ROBERT A. , KING DAVID I. , HAYES FLOYD E. , BARRY PATRICIA E. , HAYES WILLIAM K. 
Published: August 2020

SummaryCyclonic storms (often called hurricanes, typhoons, or cyclones) often cause population declines in vulnerable bird species, and the intensity of these storms appears to be increasing due to climate change. Prior studies have reported short-term impacts of hurricanes on avifauna, but few have examined long-term impacts. Over two decades (1993–2018), we periodically surveyed a subspecies of West Indian WoodpeckerMelanerpes superciliaris nyeanuson San Salvador, a small island in The Bahamas, to determine its distribution on the island, habitat use, and effects of hurricanes on abundance and population size. We conducted passive and playback surveys, supplemented with mist-netting. Woodpeckers were found only in the northern part of San Salvador, despite extensive surveys throughout other accessible areas of the island. Birds occupied areas with taller coppice adjacent to sabal palmSabal palmettogroves, which were used for nesting. After hurricanes with >160 kph winds passed over San Salvador, woodpecker densities declined to 35–40% of pre-hurricane densities, but generally recovered back to pre-hurricane densities within 2–3 years. Based on an estimated density of woodpeckers within a ~1,400 ha occupied area, we calculated a population size of approximately 240 individuals (CI = 68-408). However, the population declined to far lower numbers immediately following hurricanes. Under IUCN Red List criteria,M. s. nyeanusclassifies as ‘Critically Endangered’, and could be especially sensitive to future hurricanes if they occur at a high enough frequency or intensity to prevent the population from rebounding. Given the small size, isolation, and vulnerability of this population, we recommend preservation of the core habitat, continued monitoring, and further research. Our study shows that small, threatened bird populations can be resilient to the effects of hurricanes, but increased intensity of hurricanes, in combination with other threats, may limit this resilience in the future.
Excess mortality and shortened life expectancy in people with major mental illnesses in Taiwan
Authors: Pan Yi-Ju , Yeh Ling-Ling , Chan Hung-Yu , Chang Chin-Kuo 
Published: August 2020

Abstract

Aims
Given the concerns of health inequality associated with mental illnesses, we aimed to reveal the extent of which general mortality and life expectancy at birth in people with schizophrenia, bipolar disorder and depressive disorder varied in the 2005 and 2010 nationally representative cohorts in Taiwan.

Methods
Two nationally representative samples of individuals with schizophrenia, bipolar disorder and depressive disorder were identified from Taiwan's national health insurance database in 2005 and 2010, respectively, and followed-up for consecutive 3 years. The database was linked to nationwide mortality registry to identify causes and date of death. Age-, gender- and cause-specific mortality rates were generated, with the average follow-up period of each age- and gender-band applied as ‘weighting’ for the calculation of expected number of deaths. Age- and gender-standardised mortality ratios (SMRs) were calculated for these 3-year observation periods with Taiwanese general population in 2011/2012 as the standard population. The SMR calculations were then stratified by natural/unnatural causes and major groups of death. Corresponding life expectancies at birth were also calculated by gender, diagnosis of mental disorders and year of cohorts for further elucidation.

Results
The general differential in mortality rates for people with schizophrenia and bipolar disorder remained wide, revealing an SMR of 3.65 (95% confidence interval (CI): 3.55–3.76) for cohort 2005 and 3.27 (3.18-3.36) for cohort 2010 in schizophrenia, and 2.65 (95% CI: 2.55–2.76) for cohort 2005 and 2.39 (2.31-2.48) for cohort 2010 in bipolar disorder, respectively. The SMRs in people with depression were 1.83 (95% CI: 1.81–1.86) for cohort 2005 and 1.59 (1.57-1.61) for cohort 2010. SMRs due to unnatural causes tended to decrease in people with major mental illnesses over the years, but those due to natural causes remained relatively stable. The life expectancies at birth for schizophrenia, bipolar disorder and depression were all significantly lower than the national norms, specifically showing 14.97–15.50 years of life lost for men and 15.15–15.48 years for women in people with schizophrenia.

Conclusions
Compared to general population, the differential in mortality rates for people with major mental illnesses persisted substantial. The differential in mortality for unnatural causes of death seemed decreasing over the years, but that due to natural causes remained relatively steady. Regardless of gender, people with schizophrenia, bipolar disorder and depression were shown to have shortened life expectancies compared to general population.
AMOC Recovery in a Multicentennial Scenario Using a Coupled Atmosphere‐Ocean‐Ice Sheet Model
Authors: Ackermann L. , Danek C. , Gierz P. , Lohmann G. 
Published: August 2020

AbstractWe simulate the two Coupled Model Intercomparison Project scenarios RCP4.5 and RCP8.5, to assess the effects of melt‐induced fresh water on the Atlantic meridional overturning circulation (AMOC). We use a newly developed climate model with high resolution at the coasts, resolving the complex ocean dynamics. Our results show an AMOC recovery in simulations run with and without an included ice sheet model. We find that the ice sheet adds a strong decadal variability on the freshwater release, resulting in intervals in which it reduces the surface runoff by high accumulation rates. This compensating effect is missing in climate models without dynamic ice sheets. Therefore, we argue to assess those freshwater hosing experiments critically, which aim to parameterize Greenland's freshwater release. We assume the increasing net evaporation over the Atlantic and the resulting increase in ocean salinity, to be the main driver of the AMOC recovery.