bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors for Postoperative Recurrence of Orbital Solitary Fibrous Tumor: An Analysis of Long-Term Clinical Follow-Up Results From a Chinese Tertiary Hospital
Authors: Yang Peng , Liu Hao-Cheng , Qiu E , Wang Wei , Zhang Jia-Liang , Jiang Li-Bing , Liu Hong-Gang , Kang Jun 
Published: September 2020

Abstract
BackgroundThis study analyzed the clinical features, imaging manifestations, histopathology, immunohistochemistry, and surgical approaches of the orbital solitary fibrous tumor (OSFT), as well as the factors for postoperative recurrence of such disease.MethodsThe clinical data of 16 patients with OSFT treated in our center from 2003 to 2020 were analyzed retrospectively, and the clinical symptoms, treatment methods, and follow-up results were recorded.ResultsOf the 16 patients, 8 were females (50.0%) and 8 were males (50.0%); the average age of treatment was 37 ± 7 years and the median follow-up time was 74 (8, 228) months. Sixteen patients with OSFT underwent a total of 29 operations, of which 12 were transorbital approach operations and 17 were transfronto-orbital approach operations. Ten patients (10/16, 62.5%) had recurrence. The recurrence rate of transorbital approach operations was 83.3% (10/12), and the recurrence rate of transfronto-orbital approach operations was 17.6% (3/17). No patients had treatment-related complications.ConclusionsThe main pathological feature of OSFT is a benign tumor. OSFT has a tendency to grow toward the cranio-orbital junction. The postoperative recurrence rate of OSFT is relatively high, so complete tumor resection is very important for prognosis. Inappropriate surgical approaches can lead to incomplete removal of the tumor and cause recurrence. Choosing the correct operation approach according to the position of the OSFT in the orbit and complete removal of the dura mater and bone affected by the tumor is crucial for the prognosis. Nevertheless, regular long-term follow-up after complete resection is necessary.
Modified Meso-rex Bypass With Umbilical Vein Recanalization and Intra-operative Stenting
Authors: Tang Rui , Yu Lihan , Wu Guangdong , Li Ang , Lee I Chin , Zhang Yuewei , Yang Xiuyu , Liu Ying , Lu Qian 
Published: September 2020

Abstract
BackgroundThe aim of the study was to evaluate the usefulness of a novel modified Meso-Rex bypass surgical technique with umbilical vein recanalization and intraoperative stenting to treat portal vein cavernous transformation. MethodsIn total, 13 portal vein cavernous transformation patients underwent traditional Meso-Rex bypass surgery (Group A, n=8), modified Meso-Rex bypass without stent implantation (Group B, n=1) and modified Meso-Rex bypass with intraoperative stent implantation (Group C, n=4). ResultsIn Group A, the bypass diameter was 2-6 mm (median 3.3 mm) and blood flow velocity 25-115 cm/s (median 75 cm/s) 1 month after Meso-Rex bypass surgery, with open bypass times of 0-59 months (median 16 months); 5 patients in this group developed postoperative Meso-Rex bypass occlusions. One patient in Group B needed a thrombectomy and stent implantation during a second surgery 2 days after the modified Meso-Rex bypass, because of bypass thrombosis and umbilical vein stenosis. In Group C, the average Meso-Rex bypass diameter was 5.5-6.5 mm (median 6 mm) and the bypass vessels remained open in all patients, with blood flow rates of 45-100 cm/s (median 76.5 cm/s) 1 month after Meso-Rex bypass, up to the endpoint (12-26 months, median 18 months). The rate of bypass occlusions in Group A and Group C were 25%, 0%; 25%, 0% and 50%, 0% at 1 month, 3 months and 1 year, respectively, after Meso-Rex bypass surgery.ConclusionsOur novel modified Meso-Rex bypass approach for portal vein cavernous transformation treatment was effective with excellent long-term bypass patency.
Plant virus evolution under strong drought conditions results in a transition from parasitism to mutualism
Authors: González Rubén , Butkovic Anamarija , Escaray Francisco , Martínez-Latorre Javier , Melero Ízan , Pèrez-Parets Enric , Gómez-Cadenas Aurelio , Carrasco Pedro , Elena Santiago 
Published: September 2020

Abstract
Environmental conditions are an important factor driving pathogens evolution. Here we explore the effects of drought stress in plant virus evolution. We evolved a potyvirus in well-watered and drought conditions in Arabidopsis thaliana accessions that differ in their response to virus infection. Virus adaptation occurred in all accessions independently of watering status. Drought-evolved viruses conferred a significantly higher tolerance to drought to infected plants. By contrast, non-significant increases in tolerance were observed in plants infected with viruses evolved under standard watering. The magnitude of this effect was dependent on the plant accessions. Differences in tolerance were correlated to alterations in the expression of host genes, some involved in regulation of the circadian clock, as well as in deep changes in the balance of phytohormones regulating defense and growth signaling pathways. Our results show that viruses can promote host survival in situations of abiotic stress, being the magnitude of such benefit a selectable trait.
Isolated Pulmonary Valve Endocarditis with Rapid Progress: a Case Report and Literatures Reivew
Authors: Zhang Ming-Xuan , Zhang Wei-Min , Yu Chan , Zhao Bo-Wen , Chen Ran , Pan Mei , Wang Bei 
Published: September 2020

Abstract
Background: Isolated pulmonary valve endocarditis (IPE) is rare, accounting for 1.5-2% of all cases of infective endocarditis. Herein, we describe a case of isolated pulmonary valve endocarditis in a 28-year-old male with rapid progress. Unlike most patients reported before who were cured only by anti-infective therapy, without surgery at early stage, multiple complications occured in this patient in less than 2 weeks.Case presentation: The patient was diagnosed as pulmonary valve endocarditis with blood cultures showing Staphylococcus aureus and echocardiogram revealing 2 masses (measured 14*13mm、11*16mm respectively). Only 12 days later, acute massive pulmonary embolism occured. Then repeated echocardiogram revealed multiple massed attached to pulmonary valve with severe pulmonary insufficiency and possibility of pulmonary valve destruction. Finally, pulmonary valve replacement, vegetation removal, right pulmonary thromboendarterectomy together with resection of the middle and lower lobes of the right lung were performed. Conclusions:The role of surgery at early stage might need reconsideration, it may be viable to combine medical and surgical approaches.
Molecular Hydrogen Alleviates Asthma Through Inhibiting IL-33/ILC2&nbsp;Axis
Authors: Zhang Jingxi , Feng Xiumin , Fan Yunxin , Ning Yunye , Bai Chong 
Published: September 2020

Abstract
Background: Asthma is one of the most common noninfectious chronic diseases characterized by type II inflammation. This study aimed to investigate the effects of molecular hydrogen on the pathogenesis of asthma.Methods: OVA sensitized asthma mouse model was established and hydrogen/oxygen mixture was used to treat asthmatic mice. Serum and BALF cytokines were measured with specific ELISA assays. E-cadherin and ZO-1 were detected by immunohistochemical staining and expression of caspase 3 and 9, NF-kB, IL-33 and ST2 was assessed by quantitative real-time PCR, western blot and / or immunofluorescence. IL-33 promoter activity was analyzed by dual-luciferase assay. ILC2 population was assayed by flow cytometry and differentially expressed miRNAs were detected using miRNA array. Results: Serum and BALF levels of IL-33 and other alarmin and type II cytokines were greatly increased by OVA and inhibited by H2 in asthmatic mice. The expression of NF-kB (p65) and ST2 was upregulated by OVA and suppressed by H2. ILC2 population was markedly increased in OVA-induced asthmatic mice, and such increase was inhibited by H2. E-cadherin and ZO-1 levels in airway tissues of asthmatic mice were significantly lower than that of control mice, and the reduction was recovered by H2 treatment. H2 alleviated HDM induced apoptosis of 16HBE cells, upregulation of IL-33 and ST2, and elevation of IL-33 promoter activity. A group of miRNAs differentially expressed in HDM and HDM+H2 treated 16HBE cells were identified. Conclusions: These data demonstrated that H2 is efficient in suppressing allergen-induced asthma and could be developed as a therapeutic method for asthma and other conditions of type II inflammation.
Pulmonary fibrosis following infection with SARS-CoV-2 in a pregnant woman: case report
Authors: Moeindarbary Somaye , Dadgar Salmeh , Layegh Parvaneh , Shahriari Zahra , Fayyaz Faezeh , Danesteh Sina , Rafiee Mahdi , Bahrami Milad 
Published: September 2020

Abstract
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third coronavirus that make a global concern in 21th century. Pregnant women are particularly at higher risk of developing severe viral pneumonia, possibly because of a partial immune suppression during their pregnancy. Under such critical and rapidly evolving circumstances, these poor findings might be helpful for the treatment of infected pregnant women with 2019-nCoV.Case presentation: In this study, we have reported a pregnant woman at 25 gestational weeks with COVID-19 who has developed severe complications, including hypoxemia, acute respiratory distress syndrome (ARDS), pulmonary fibrosis, and bilateral pleural effusion. In the end, she died one month after admission to the hospital.Conclusion: Pregnant population are especially more at risk of viral pneumonia caused by coronaviruses, further research on the prevention and treatment of new coronavirus is necessary.
To determine the prevalence of hypertension and its lifestyle risk factors in Amhara Region of Debre Birehan Town among Zonal Civil Servants, Ethiopia
Authors: Wolle Solomon Zewdu , Kebed Shamble Mengesha , Alemu Zewdie Aderaw 
Published: September 2020

Abstract
Background: Hypertension is defined as arterial blood pressure that exceeds 140/90mmhg. Hypertension is one of the most common disease afflicting humans throughout the world. The main objective of this study was to determine the prevalence of hypertension and its risk factors among Debre Berhan Zonal sector civil servants. Methods: Cross sectional systematic random sampling study were conducted on civil servants of Debre Berhan Zonal sectors by taking a total sample size of 264. And physical measurement based data were collected by investigators through structured and pretested interview administered questionnaire. Results: A total of 259 (98.1%) participants were included in this study. Prevalence of hypertension was 68(26.2%) and undiagnosed hypertension was 34 (13.3%). About 43% of the respondents reported they had never checked their blood pressure within the past 2 years and above. Factors found to be associated with hypertension include: older age, educational status, family history of hypertension, current cigarette smoker and obesity.Conclusions and Recommendations: There was high prevalence of both diagnosed and undiagnosed hypertension. There is an urgent need for strategies and program to prevent and control high blood pressure, and promote healthy lifestyle.
CCL2&nbsp;Facilitates Spinal Synaptic Transmission and Pain via Interaction With Presynaptic CCR2&nbsp;in Spinal Nociceptor Terminals&nbsp;
Authors: Ma Sui-Bin , Xian Hang , Wu Wen-Bin , Ma Shuo-Yao , Liu Yu-Ke , Liang Yu-Tong , Guo Huan , Kang Jun-Jun , Liu Ying-Ying , Zhang Hui , Wu Sheng-Xi , Luo Ceng , Xie Rougang 
Published: September 2020

Abstract
Previous studies have shown that CCL2 may cause chronic pain, but the exact mechanism of central sensitization is unclear. In this article, we further explore the presynaptic role of CCL2. Behavioral experiments show that intervertebral foramen injection CCR2 antagonists into dorsal root ganglion (DRG) can inhibit the inflammatory pain caused by CCL2 in spinal cord. We raised the question of the role of presynaptic CCR2 in the spinal dorsal horn. Subsequent electron microscopy experiments showed that CCR2 was expressed in the presynaptic CGRP terminal in the spinal dorsal horn. CCL2 can enhance presynaptic calcium signal. Whole-cell patch-clamp recordings showed that CCL2 can enhance NMDAR-eEPSCs through presynaptic effects, and further application of glutamate sensor method proved that CCL2 can act on presynaptic CCR2 to increase the release of presynaptic glutamate. In conclusion, we suggest that CCL2 can directly act on the CCR2 on presynaptic terminals of sensory neurons in the spinal dorsal horn, leading to an increase in the release of presynaptic glutamate and participate in the formation of central sensitization.
Traditional Food Plants of the Upper Aswa River Catchment of Northern Uganda - A Cultural Crossroads
Authors: Masters Eliot Thomas 
Published: September 2020

Abstract
Background In the parkland agroforestry system of northern Uganda, smallholder farming households rely on a diversity of plant species to fulfil their nutritional requirements, many of which also serve a range of medicinal, cultural and livelihood functions. A longitudinal study of the utilization and management of on-farm plant biodiversity by rural communities was undertaken, over several decades, with a specific focus on wild and semi-cultivated food plants. The purpose of the study was to assemble an inventory of indigenous plant species used as food in four districts within the Aswa River catchment of northern Uganda.MethodsFocus group discussions were conducted at 34 locations. Plant specimens were collected during field walks, and submitted to the Makerere University Herbarium for identification. Key informant interviews were conducted to document the botanical, ecological, seasonal and alimentary attributes of each species, and details of its processing and utilization.Results The study presents the edible plants of four districts in the Aswa River catchment of northern Uganda. A total of 232 key informant interviews yielded 1,303 use reports (URs) for 373 identified specimens of 95 edible species. The data constitute an inventory of on-farm plant species, including cultivated, semi-cultivated and wild plants, integrated into a parkland agroforestry system in which useful trees and other plant species are sustained and managed under cultivation. Conclusions Agricultural and on-farm plant biodiversity may be seen as a food security resource, and a nutritional buffer against increasing risks and stressors on low-input smallholder agriculture. Further studies should assess the intra-species biodiversity of these resources, with respect to farmer-valued traits and vernacular (folk) classification systems.
Characteristics and Clinical Significance of Spondylolisthetic and Spino-pelvic Sagittal Parameters in Kyphotic Low-grade Degenerative Lumbar Spondylolisthesis
Authors: Xu Chongqing , Yin Mengchen , Mo Wen 
Published: September 2020

Abstract
Background: Degenerative lumbar spondylolisthesis (DLS) has been a common disease that make increasing patients suffer from different degrees of low back pain and radicular symptoms. At present, the incidence of kyphosis in DLS and the differences in spinal sagittal morphology between kyphotic and non-kyphotic DLS still remain unclear. Our study aimed to determine the incidence of kyphosis in DLS, explore the characteristics of spondylolisthetic and spino-pelvic sagittal parameters, and evaluate the impact of kyphosis on the life quality of patients with DLS.Methods/Design: All 108 patients with L4/5 low-grade DLS were enrolled and divided into kyphotic and non-kyphotic group. 2 spine surgeons who have certain clinical experience were selected to measure the spondylolisthetic and spino-pelvic parameters, as well as visual analogue scale (VAS) and Oswestry disability index (ODI). Differences between the 2 groups and characteristics of measurements were analyzed.Results: The inter-observer agreement of all parameters between the 2 spine surgeons were excellent with each ICC > 0.75. Kyphotic group had higher SA, SD, SDM, SAM, PDH, PT and SVA, and lower ADH, SS and LL than those in non-kyphotic group (p < 0.01). There was no significant difference in PI and TK between the two groups (p > 0.05).Conclusion: The incidence of kyphotic spondylolisthesis in patients with L4/5 low-grade DLS is 16.7%. Compared with those in non-kyphotic group, patients with kyphosis show inferior results of spondylolisthetic parameters, more severe loss of LL, more obvious pelvic retroversion and trunk anteversion, which indicates worse spino-pelvic sagittal balance. In addition, their quality of life was significantly lower than that of patients in non-kyphotic group.
In Vitro Evaluation of The Activity of Ceftazidime-Avibactam and Aztreonam-Avibactam Against 76 Stenotrophomonas Maltophilia Isolates From A Teaching Hospital in Chongqing
Authors: Lin Qiuxia , Zou Hua , Chen Xian , Wu Menglu , Ma Deyu , Yu Hanbing , Niu Siqiang , Huang Shifeng 
Published: September 2020

Abstract
Background: Treatment options for Stenotrophomonas maltophilia (S. maltophilia) infections were limited. We assessed the efficacy of ceftazidime-avibactam (CAZ-AVI) and aztreonam-avibactam (ATM-AVI) against a selection of 76 S. maltophilia out of the 1179 strains isolated from the First Affiliated Hospital of Chongqing Medical University during 2011-2018.Methods: We investigated the antimicrobial resistance profiles of the 1179 S. maltophilia clinical isolates from the first affiliated hospital of Chongqing Medical University during 2011-2018, a collection of 76 isolates of which were available for further study of microbiological characterization. Minimum inhibitory concentrations (MICs) of ceftazidime (CAZ), ceftazidime-avibactam (CAZ-AVI), aztreonam (ATM) and aztreonam-avibactam (ATM-AVI) were determined via the broth microdilution method. We deemed that CAZ-AVI or ATM-AVI was more effective in vitro than CAZ or ATM alone when CAZ-AVI or ATM-AVI led to a category change from “Resistant” with CAZ or ATM alone to “Susceptible” or “Intermediate” with CAZ-AVI or ATM-AVI, or if the MIC of CAZ-AVI or ATM-AVI was at least 2-fold lower than the MIC of CAZ or ATM alone.Results: For the 76 clinical isolates included in the study, MICs of CAZ, ATM, CAZ-AVI and ATM-AVI ranged from 0.03-64, 1-1024, 0.016-64, and 0.06-64 μg/mL, respectively. In combined therapy, AVI was effective at restoring the susceptibility of 48.48% (16/33) and 89.71% (61/68) of S. maltophilia to CAZ and ATM, respectively. Furthermore, CAZ-AVI showed better results in terms of the proportion of susceptible isolates (77.63% vs.56.58%, P<0.001), MIC50 (2μg/mL vs. 8μg/mL, P<0.05), and MIC distribution (P<0.001) when compared to CAZ. According to our definition, CAZ-AVI was more effective in vitro than CAZ alone for 84.21% of the isolates. Similarly, ATM-AVI also showed better results in terms of the proportion of susceptible isolates (90.79%vs. 10.53%, P<0.001), MIC50 (2μg/mL vs. 64μg/mL, P<0.001), and MIC distribution (P<0.001) when compared to ATM. According to our definition, ATM-AVI was also more effective in vitro than ATM alone for 97.37% of the isolates.Conclusions: AVI potentiated the activity of both CAZ and ATM against S. maltophilia clinical isolates in vitro. We demonstrated that CAZ-AVI and ATM-AVI are both useful therapeutic options to treat infections caused by S. maltophilia.
The Impact of Spousal Chronic Health Shock on Subjective Well-Being Among Elderly in China: An Urban-Rural Dimension
Authors: Zhou Zhongliang , Cao Dan , Zhao Yaxin , Zhao Dantong , Ren Yangling , Nawaz Rashed , Zhang Jian , Shen Chi , Liu Guanping , Zhai Xiaohui , Fan Xiaojing , Gao Jianmin 
Published: September 2020

Abstract
Backgrounds Chronic conditions could bring not only heavy economic burden on families, but also had negative emotional and mental impacts to patients and their family members. The aim of this study is to explore the effect of chronic health shock of elderly people on spousal subjective well-being in China from urban-rural dimension.Methods We used two most recent databases —2011 and 2015—of China Health and Nutrition Survey, and the total sample were categorized into urban sample and rural sample. Participants were defined as treatment group if his/her spouse was diagnosed with chronic disease in 2015 and not diagnosed in 2011; others were defined as control group. Propensity score matching was used to evaluate the average treatment effect of treated(ATT)of spousal chronic health shock. Ordinary linear square(OLS) regression was also deployed to explore the relationship between spousal chronic health shock and subjective well-being.Results The total sample size was 2577, with 1023 in urban area and 1554 in rural area. ATT in urban area was -0.209 in radius matching with caliper, and it is statistically significant; however, in rural area, ATT was 0.069, and it didn’t achieve statistical significance. The results of OLS regression after PSM also suggested that spousal chronic health shock had a negative effect on subjective well-being of urban elderly, and for rural elderly, there was no such an effect.Conclusions Our study highlights more attention needs to be paid in subjective well-being of individual whose spouse suffers from chronic conditions, especially in urban China.
Ultrasound-Accelerated Thrombolysis in High-Risk Perioperative Pulmonary Embolism: Two Case Reports and Review of Literature
Authors: Schmidt Götz , Edinger Fabian , Koch Christian , Wolff Matthias , Biehl Christoph , Hörbelt Rüdiger , Sander Michael 
Published: September 2020

Abstract
Background: Treatment of high-risk pulmonary embolism (PE) in perioperative patients remains challenging. Systemic thrombolysis is associated with a high risk of major bleedings and intracranial haemorrhage. High mortality rates are reported for open pulmonary embolectomy. Therefore, postoperative surgical patients may benefit substantially from catheter-directed ultrasound-accelerated thrombolysis (USAT).Case summary: We report two cases of high-risk perioperative PE. Both patients developed severe haemodynamic instability leading to cardiac arrest. After the implantation of a veno-arterial extracorporeal membrane oxygenation (ECMO), they were both successfully treated with USAT. Adequate improvement of right ventricular function was achieved; thus, ECMO could be successfully weaned after three and four days, respectively. Both patients showed favourable outcomes and could be discharged to rehabilitation. Discussion: The current European guideline on treatment of PE offers no specific therapies for perioperative patients with high-risk PE. However, systemic thrombolysis is often excluded due to the perioperative setting and the risk of major bleeding. Catheter-directed thrombolysis was shown to utilise less thrombolytic agent while obtaining comparable thrombolytic effects. The risk for major bleeding (including intracranial haemorrhage) is also significantly lowered. Conclusion: Further prospective randomised controlled trials are necessary to determine the value of USAT treatment of high-risk PE in perioperative patients.