bluuebunny/crossref_metadata_2025_split huggingface dataset:
Restoration of myocellular copper-trafficking proteins and mitochondrial copper enzymes repairs cardiac function in rats with diabetes-evoked heart failure
Authors: Zhang Shaoping , Liu Hong , Amarsingh Greeshma Vazhoor , Cheung Carlos C H , Wu Donghai , Narayanan Umayal , Zhang Linda , Cooper Garth J S 
Published: December 2019

AbstractDiabetes impairs systemic copper regulation, and acts as a major independent risk factor for heart failure (HF) wherein mitochondrial dysfunction is a key pathogenic process. Here we asked whether diabetes might alter mitochondrial structure/function and thus impair cardiac performance by damaging myocellular pathways that mediate cell-copper homeostasis. We measured activity of major mitochondria-resident copper-enzymes cytochrome c oxidase (mt-Cco) and superoxide dismutase 1 (mt-Sod1); expression of three main mitochondrial copper-chaperones [Cco copper chaperone 17 (Cox17), Cox11, and mitochondria-resident copper chaperone for Sod1 (mt-Ccs)]; of copper-dependent Cco-assembly protein Sco1; and regulation of mitochondrial biogenesis, in left-ventricular (LV) tissue from groups of non-diabetic-control, untreated-diabetic, and divalent-copper-selective chelator-treated diabetic rats. Diabetes impaired LV pump function; ∼halved LV-copper levels; substantively decreased myocellular expression of copper chaperones, and enzymatic activity of mt-Cco and mt-Sod1. Divalent-copper chelation with triethylenetetramine improved cardiac pump function, restored levels of myocardial copper, the copper chaperones, and Sco1; and enzymatic activity of mt-Cco and mt-Sod1. Copper chelation also restored expression of the key mitochondrial biogenesis regulator, peroxisome-proliferator-activated receptor gamma co-activator-1α (Pgc-1α). This study shows for the first time that altered myocardial copper-trafficking is a key pathogenic process in diabetes-evoked HF. We also describe a novel therapeutic effect of divalent-copper-selective chelation, namely restoration of myocellular copper trafficking, which is thus revealed as a potentially tractable target for novel pharmacological intervention to improve cardiac function.
Photoelectric detection of crop fungi resistance based on microfluidic
Authors: Xu Peifeng , Wu Gangshan , Xu Chao , Wang Pan , Yang Ning , Zhang Rongbiao 
Published: December 2019

In view of the defects such as long time‐consuming and large limitation in the detection of pesticide resistance of crop pathogens at present. A novel photoelectric detection method based on enriched microfluidic chips is proposed for the detection of pesticide resistance of crop fungal disease. First, according to the aerodynamics characteristics of microbial aerosol particles and optical detection technology, a special enrichment microfluidic chip was designed to achieve high efficiency enrichment and high precision concentration detection of fungal spores. On this basis, based on the theory of pesticide resistance sensitivity baseline, the relationship among spore germination, systematic enrichment concentration, and optical detection concentration of Botrytis cinerea in strawberry treated with Pyrimethanil was studied, and the pesticide resistance detection model of uncultured pathogens was established. The light intensity of light source was 1.1 × 103 cd, and the wavelength was 620 nm as the optimum parameters for optical detection. The correlation coefficient between the microscopic examination of spores’ concentration and the results of optical detection is 0.9792. It has good linearity and reliability, which provides a theoretical basis for the research and development of portable equipment for detecting pesticide resistance of crop diseases.
The dry and carbon-poor inner disk of TW Hydrae: evidence for a massive icy dust trap
Authors: Bosman Arthur D. , Banzatti Andrea 
Published: December 2019

Context. Gas giants accrete their envelopes from the gas and dust of proto-planetary disks, and therefore it is important to determine the composition of the inner few astronomical units, where most giant planets are expected to form.
Aims. We aim to constrain the elemental carbon and oxygen abundance in the inner disk (R <  2.3 AU) of TW Hya and compare with the outer disk (R >  2.3 AU) where carbon and oxygen appear underabundant by a factor of approximately 50.
Methods. Archival Spitzer-IRS and VLT-CRIRES observations of TW Hya were compared with a detailed thermo-chemical model, DALI. The inner disk gas mass and elemental C and O abundances were varied to fit the mid-infrared H2 and H2O line fluxes as well as the near-infrared CO line flux.
Results. Best-fitting models have an inner disk that has a gas mass of 2 × 10−4 M⊙ with C/H ≈ 3 × 10−6 and O/H ≈ 6 × 10−6. The elemental oxygen and carbon abundances of the inner disk are about 50 times lower than in the interstellar medium and are consistent with those found in the outer disk.
Conclusions. The uniformly low volatile abundances imply that the inner disk is not enriched by ices on drifting bodies that evaporate. This indicates that drifting grains are stopped in a dust trap outside the water ice line. Such a dust trap would also form a cavity as seen in high-resolution submillimeter continuum observations. If CO is the major carbon carrier in the ices, dust needs to be trapped efficiently outside the CO ice line of ∼20 AU. This would imply that the shallow submillimeter rings in the TW Hya disk outside of 20 AU correspond to very efficient dust traps. The most likely scenario is that more than 98% of the CO has been converted into less volatile species, for example CO2 and CH3OH. A giant planet forming in the inner disk would be accreting gas with low carbon and oxygen abundances as well as very little icy dust, potentially leading to a planet atmosphere with strongly substellar C/H and O/H ratios.
Disks Around T Tauri Stars with SPHERE (DARTTS-S)
Authors: Garufi A. , Avenhaus H. , Pérez S. , Quanz S. P. , van Holstein R. G. , Bertrang G. H.-M. , Casassus S. , Cieza L. , Principe D. A. , van der Plas G. , Zurlo A. 
Published: December 2019

Context. Near-IR polarimetric images of protoplanetary disks enable us to characterize substructures that might be due to the interaction with (forming) planets. The available census is strongly biased toward massive disks around old stars, however.
Aims. The DARTTS program aims at alleviating this bias by imaging a large number of T Tauri stars with diverse properties.
Methods. DARTTS-S employs VLT/SPHERE to image the polarized scattered light from disks. In parallel, DARTTS-A provides ALMA images of the same targets for a comparison of different dust components. In this work, we present new SPHERE images of 21 circumstellar disks, which is the largest sample released to date. We also recalculated some relevant stellar and disk properties following Gaia DR2.
Results. The targets of this work are significantly younger than those published thus far with polarimetric near-IR (NIR) imaging. Scattered light is unambiguously resolved in 11 targets, and some polarized unresolved signal is detected in 3 additional sources. Some disk substructures are detected. However, the paucity of spirals and shadows from this sample reinforces the trend according to which these NIR features are associated with Herbig stars, either because they are older or more massive. Furthermore, disk rings that are apparent in ALMA observations of some targets do not appear to have corresponding detections with SPHERE. Inner cavities larger than ~15 au are also absent from our images, even though they are expected from the spectral energy distribution. On the other hand, 3 objects show extended filaments at larger scale that are indicative of strong interaction with the surrounding medium. All but one of the undetected disks are best explained by their limited size (≲20 au), and the high occurrence of stellar companions in these sources suggests an important role in limiting the disk size. One undetected disk is massive and very large at millimeter wavelengths, implying that it is self-shadowed in the NIR.
Conclusions. This work paves the way toward a more complete and less biased sample of scattered-light observations, which is required to interpret how disk features evolve throughout the disk lifetime.
Plattenepithelkarzinome der Kopf-Hals-Region (SCCHN)
Authors: Pogorzelski Michael , Grünwald Viktor 
Published: December 2019

Was ist neu?
Prävention Die Aufklärung der Bevölkerung über den gesicherten Zusammenhang von Alkohol- und Tabakkonsum mit der Entstehung von Kopf-Hals-Tumoren ist weiterhin dringend erforderlich. Zur Prävention der HPV-assoziierten Tumoren stehen Vakzine zur Verfügung. Gemäß der Empfehlung der STIKO sollten alle Jungen und Mädchen im Alter zwischen 9 und 14 Jahren geimpft werden.
Ausbreitungs- und Rezidivdiagnostik Die FDG-PET/CT ermöglicht die Verringerung operativer Eingriffe. Bei N2/N3-Status nach definitiver Radiochemotherapie (RCT) sollte eine Neck Dissection nur bei positivem/unklarem PET-Befund durchgeführt werden. Bei Verdacht auf ein Rezidiv eines Larynxkarzinoms kann die FDG-PET/CT helfen, eine Larynxbiopsie zu vermeiden. Bei zervikalem CUP-Syndrom (d.h. bei unklarem Primärtumor) ist sie zudem zur Primarius- und Ausbreitungsdiagnostik indiziert.
Stadieneinteilung und Prognostizierung HPV-induzierte Oropharynxkarzinome weisen eine bessere Prognose auf. Die 8. Version der TNM-Klassifikation umfasst daher eine klinische und eine pathologische Klassifikation für diese Tumorentität. Die Therapieplanung erfolgt auch weiterhin nach den etablierten Kriterien der 7. Version.
Lokal fortgeschrittene Stadien Zur Reduktion therapieassoziierter Toxizität wird derzeit eine Therapiedeeskalation bei HPV-assoziierten Oropharynxkarzinomen (HPV-OPC) evaluiert. Bisherige Studien waren jedoch negativ, sodass derzeit keine Anpassung der Therapie anhand des HPV-Status im klinischen Alltag erfolgt.
Palliative Systemtherapie Die Immuncheckpointinhibitoren Nivolumab und Pembrolizumab stellen den neuen Standard nach Versagen einer platinhaltigen Therapie dar. In der Keynote-048-Studie demonstrierte Pembrolizumab als Monotherapie für Patienten mit Expression von PD-L1 (CPS ≥ 1) sowie in der Kombination mit Platin + 5-FU in der unselektierten Patientenpopulation seine Überlegenheit gegenüber dem bisherigen Erstlinienstandard PFC.
Das Schmidt-Syndrom
Authors: Stahn Bonnie , Scheit Lorenz 
Published: December 2019

Zusammenfassung
Anamnese und klinischer Befund Wir berichten über einen 22-jährigen Patienten, der sich mit Abgeschlagenheit, Gewichtsverlust und Verfärbung der Haut vorstellte. Eine Hashimoto-Thyreoiditis war bekannt. Die Hormonsubstitution mit L-Thyroxin war bereits erhöht worden. Allerdings persistierten die Beschwerden.
Diagnostik Die körperliche Untersuchung zeigte eine gelblich-graue Verfärbung der Haut. Zudem fielen laborchemisch eine Hyponatriämie und eine Hyperkaliämie auf. Kortisolspiegel, Antikörperbestimmungen sowie ein ACTH-Stimulationstest bestätigten die Diagnose eines Morbus Addison. In Zusammenschau mit der bekannten Hashimoto-Thyreoiditis ergab sich das Bild eines Schmidt-Syndroms.
Therapie und Verlauf Es erfolgte die Substitution mit 20 mg Hydro- und 0,1 mg Fludrokortison täglich, worunter es innerhalb einer Woche zur Beschwerdebesserung und Normalisierung der Laborparameter kam.
Folgerung Die Erkrankungen und Symptome, die im Rahmen einer autoimmunen Polyendokrinopathie vorliegen können, erschweren häufig eine schnelle Diagnose. Daher sollte bei Patienten mit bereits bekannter Autoimmunerkrankung an die Möglichkeit einer autoimmunen Polyendokrinopathie gedacht werden.
Bariatric endoscopy procedure type or follow-up: What predicted success at 1 year in 962 obese patients?
Authors: Lopez-Nava Gontrand , Asokkumar Ravishankar , Rull Angel , Corbelle Fernandez , Beltran Lucia , Bautista Inmaculada 
Published: December 2019

Abstract
Background and study aims It is uncertain if the difference in weight loss outcomes between different endoscopic bariatric therapies (EBTs) is technique-related or multidisciplinary team (MDT) follow-up-related. We hypothesized that at 1 year, the weight loss is determined more by adherence to MDT follow-up than by procedure type. We aimed to compare 1 year weight loss outcomes of four different EBTs at a single center with a standardized MDT follow-up.
Patients and methods We prospectively collected and retrospectively analyzed outcomes in 962 patients (female-691, 71.2 %; mean age, 44.8 ± 10.6 years, mean BMI, 37.8 ± 5.9 Kg/m2) treated with Intragastric balloons (IGBs) or endoscopic gastroplasty (EG) at HM Sanchinarro University Hospital between March 2012 to January 2017. The procedures were performed by the same endoscopist and followed up by the same MDT. We compared the percentage total body weight loss (%TWBL) at 1 year. We performed linear and logistic regression to identify predictive factors for weight loss and follow-up adherence at 1 year.
Results Four hundred and eighty-one IGBs (Orbera-80.9 %; ReShape Duo-19.1 %), and 481 EG (Apollo ESG-51.3 %; Primary obesity surgery endoluminal-POSE-48.6 %) were performed. Only 480 patients (IGB- 45 %; EG- 55 %) completed 1 year follow-up. Among them, Apollo ESG achieved significantly higher TBWL (19.5 ± 13 %, P = 0.035), %TBWL (17.4 ± 10.2 %, P = 0.025), and ≥ 20 % TBWL (36.7 %, P = 0.032). However, in linear regression after adjusting for variables, only higher initial BMI (B = 0.31, P < 0.001) and higher percentage follow-up attendance (B = 0.24, P < 0.001) significantly predicted %TBWL at 1 year in the completion group but not the procedure type (B = 0.02, P = 0.72). In logistic regression, we observed female sex (P = 0.01), high initial BMI (P < 0.001), endoscopic gastroplasty (P = 0.04), and high 1-month %TBWL (P < 0.001) significantly predicted follow-up completion at 1 year.
Conclusions Weight loss at 1 year is dependent on MDT follow-up rather than procedure type. Endoscopic gastroplasty promoted follow-up adherence more than IGBs.
Untersuchungen zum Verlauf der Lebensqualität vor und bis 2 Jahre nach anatomischer Resektion bei Patienten mit Lungenkarzinom – ein Vergleich zwischen anterolateraler Thorakotomie und videoassistierter Thorakoskopie
Authors: Hoeffkes Daniel , Welcker Katrin , Hendrix Holger , Kamlak Vladimir , Prisadov Georgi , Noack Frank , Meyer Andreas 
Published: December 2019

Zusammenfassung
Hintergrund Es existieren zahlreiche Publikationen, aus denen hervorgeht, dass in der operativen Therapie des nicht kleinzelligen Lungenkarzinoms durch einen minimalinvasiven Zugang vergleichbare onkologische Resektionsergebnisse erzielt werden wie nach einer Thorakotomie. Herausgearbeitet wurde außerdem, dass ein minimalinvasiver Zugang mit geringeren postoperativen Komplikationen und einem kürzeren Krankenhausaufenthalt einhergeht. Ungeklärt ist jedoch bisher, ob die Wahl des operativen Zugangs mit einem Unterschied in der gesundheitsbezogenen Lebensqualität assoziiert ist.
Material und Methoden Aus dem Patientenkollektiv unseres von der Deutschen Krebsgesellschaft (DKG) zertifizierten Lungenkrebszentrums wurden 327 Patienten befragt, die zwischen 2010 und 2017 operiert wurden. Ausgehend von insgesamt 456 verwertbaren Short-Form-12-Fragebögen wurden standardisierte Kenngrößen für das subjektiv empfundene physische und psychische Wohlbefinden gebildet. Diese wurden zunächst zu Kenngrößen der deutschen Normbevölkerung in Relation gesetzt, bevor eine Gegenüberstellung der Lebensqualität von Patienten nach anterolateraler Thorakotomie mit denen von Patienten nach einer videoassistierten Thorakoskopie erfolgte.
Ergebnisse Mit einigen Limitationen konnte herausgearbeitet werden, dass die körperliche Dimension der postoperativen Lebensqualität von Patienten mit einem nicht kleinzelligen Lungenkarzinom langfristig eingeschränkt bleibt, während die psychische Dimension nicht relevant eingeschränkt ist. Hierbei ist die Wahl eines minimalinvasiven Zugangs postoperativ nicht mit einer höheren gesundheitsbezogenen Lebensqualität assoziiert.
Schlussfolgerungen Unter dem Aspekt der gesundheitsbezogenen Lebensqualität scheinen beide Zugangswege gleichwertig. Der Trend in der Entwicklung sowohl der körperlichen als auch der psychischen Dimension der Lebensqualität nach videoassistierter Thorakoskopie deutet jedoch einen längerfristigen Vorteil des minimalinvasiven Zugangs an.
Efficacy and Safety of Nonvitamin K Oral Anticoagulants in Patients with Atrial Fibrillation and Cancer: A Study-Level Meta-Analysis
Authors: Cavallari Ilaria , Verolino Giuseppe , Romano Silvio , Patti Giuseppe 
Published: December 2019

Abstract
Objectives In this study-level meta-analysis, we evaluated the clinical outcome with nonvitamin K antagonist oral anticoagulants (NOACs) versus vitamin K antagonists (VKAs) in atrial fibrillation (AF) patients with cancer.
Background Anticoagulation in AF patients with cancer is challenging given the coexistence of elevated thrombotic and bleeding risk. The efficacy and safety of NOACs in this setting remain unclear.
Methods We included three randomized trials in our primary analysis (N = 2,661 patients) and three observational studies in our secondary, confirmatory analysis (N = 21,112 patients). Outcome measures were: the composite of any stroke or systemic embolism, ischemic stroke, venous thromboembolism, major bleeding, intracranial bleeding; and all-cause death. Mean follow-up duration was 2.2 years.
Results In the primary analysis, the use of NOACs was associated with similar incidence of stroke/systemic embolism (odds ratio [OR] 0.70, 95% confidence interval 0.45–1.09; p = 0.11), ischemic stroke (OR 0.71, 0.31–1.64; p = 0.42), venous thromboembolism (OR 0.91, 0.33–2.53; p = 0.86), all-cause death (OR 1.02, 0.72–1.42; p = 0.93), and major bleeding (OR 0.81, 0.61–1.06; p = 0.13) compared with VKAs. The occurrence of intracranial bleeding was significantly lower in the NOACs versus VKAs group (OR 0.11, 0.02–0.63; p = 0.01). These results were overall confirmed in the secondary analysis, where there was additionally a significant reduction of stroke/systemic embolism, ischemic stroke, and venous thromboembolism with NOACs.
Conclusion In AF patients with malignancy, NOACs appear at least as effective as VKAs in preventing thrombotic events and reduce intracranial bleeding. NOACs may represent a valid and more practical alternative to VKAs in this setting of high-risk patients.
Segmental Arterial Mediolysis with Supra-Aortic Vascular Involvement: Report of Two Cases
Authors: Jain Vikash 
Published: December 2019

AbstractSegmental arterial mediolysis (SAM) is a rare noninflammatory vasculopathy predominantly involving the visceral arteries of the abdomen. The most common presentation described is massive intra-abdominal hemorrhage secondary to aneurysm rupture. In this report, we describe two cases with characteristic findings of aneurysm, dissection, and beading involving the visceral arteries and the supra-aortic vessels. SAM involving the supra-aortic vessels is extremely rare.
The effect of a worldwide tax system on tax management of foreign subsidiaries
Authors: Kohlhase Saskia , Pierk Jochen 
Published: December 2019

AbstractUnder a worldwide tax system, firms pay taxes on their domestic income and repatriated foreign income, whereas under a territorial tax system repatriated foreign income is exempt from taxation. We examine whether worldwide tax systems reduce the incentives of multinational corporations to engage in tax management in their foreign subsidiaries. Using two quasi-natural experiments, we show that multinationals lower the effective tax rates in their foreign subsidiaries after countries switch from a worldwide to a territorial tax system. Thus, multinationals subject to a worldwide tax system face competitive disadvantages compared to competitors from countries with a territorial tax system.
Microsecond pulse erbium-doped fiber laser using WS2 deposited on D-shaped fiber fabricated by polishing wheel technique
Authors: Jafry A A A , Kasim N , Munajat Y , Yusoff R A M , Harun S W 
Published: December 2019

Abstract
We demonstrate a stable Q-switching pulse train output centered at 1561 nm by implementing D-shaped fiber deposited tungsten disulphide (WS2) as a saturable absorber in erbium-doped fiber laser. D-shaped fiber was fabricated using a polishing wheel technique with two stages polishing. Proposed Q-switched EDFL generates a maximum repetition rate of 47.28 kHz at a pulse duration of 5.4 us. Under pump power of 104.6 mW, the laser consumed pulse energy of 99.4 nJ with an output power of 4.7 mW. This WS2-D-shaped SA is excellence for the production of Q-switched laser source.
Photochemical reduction of carbonyl group of polyimide by 450 nm diode laser
Authors: Roslan M S , Kamarudin H , Sharip N , Zin A F M , Muhamad A , Agam A , Nayan N , Tariq U 
Published: December 2019

Abstract
In this article, we report directly patterned graphene nanoribbons by laser irradiation. The transformation of polymer into graphene nanostructure by breaking oxygen bonding and followed by graphitization of carbon atoms has been employed by using the photochemical technique. The scalable and fast growth of graphene nanoribbon was carried out by irradiating 450 nm diode laser directly onto polyimide polymer. Patterned graphene was characterized by Raman spectroscopy, Fourier transform infrared spectroscopy (FTIR) and Field emission scanning electron microscopy (FESEM). The ability of polyimide to absorb laser light in the near-ultraviolet region contribute to the tailoring of graphene nanoribbon which reduces oxygen bonding as well as paves way for the development of optoelectronics applications.
A study of relative humidity sensor on micro-ball resonator
Authors: Ali U U M , Johari M A M , Jusoh Z , Rahman H A , Harun S W 
Published: December 2019

Abstract
We investigate the use of a class of whispering gallery mode optical resonators, namely, optical micro-ball resonator (MBR) as a relative humidity (RH) sensor. The MBR is fabricated using fusion splicer at the tip of standard optical fibers; single-mode fibers (SMF-28). The MBR is then optically excited by using an 8?? optical microfiber and was found to have a Q-factor of >105. The MBR was then employed as a humidity sensor with an RH range of between 40% to 100%. The MBR RH sensor was found to have a sensitivity 0.284 dB/%, linearity >90% and is superior to the bare microfiber in all measured parameters. The MBR RH sensor was also found to have good repeatability and stability compared to bare microfiber.
PMMA microball resonator for formaldehyde liquid sensing
Authors: Sharif M M , Rahim H R A , Johari M A M , Abdul Khudus M I M , Harun S W 
Published: December 2019

Abstract
This experiment reports the fabrication of the Polymethyl Methaclyrate (PMMA) Microball Resonator (MBlR) as a liquid sensor tested on various level of concentration of the Formaldedhye liquid. The PMMA MBlR is fabricated via the “dipped and twirl” method to create the sphere-shaped ball with diameter Db = 320um. The MBlR is then optically excited using a 9|am PMMA microfiber and was found to have a Q Factor of >104. The MBlR was then employed as a liquid sensor with the level percentage range between 0% to 4% of Formaldehyde liquid and the performance is compared with a non MBlR microfiber. The MBlR sensor was found to have a sensitivity of 6.94 dBm/%, linearity >90% and P-value of more than 105. The PMMA MBlR liquid sensor was also found to have good repeatability and stability over a period of 60 seconds.