bluuebunny/crossref_metadata_2025_split huggingface dataset:
Industrial Perspective on Hydrogen Purification, Compression, Storage, and Distribution
Authors: Peschel A. 
Published: August 2020

AbstractGreen hydrogen production by electrolysis using renewable power allows for decoupling the time and location of hydrogen production and use. Even if pipeline transport of hydrogen is most economic for large scale, transport by trailers will be present in near and mid‐term future since the construction of a hydrogen pipeline network will take a long time. Furthermore, the volume of trailer transport will increase with increasing hydrogen demand raising the question what the best hydrogen carrier is.Within this contribution, different hydrogen carriers are compared regarding their energy efficiency and their practicability. In addition, an overview of hydrogen compression technology is given including piston, membrane, screw, electrochemical, thermal, and turbo compressors. As hydrogen carriers, gaseous compressed hydrogen (CGH), liquid hydrogen, (LH2), liquid organic hydrogen carriers (LOHC), metal organic frameworks (MOF), hydrides and ammonia are evaluated. CGH is most energy efficient for short transport distances, but for longer distances a higher hydrogen density is required. Here, LH2 and LOHCs compete both showing a high hydrogen density. However, if larger hydrogen liquefiers are built in future, LH2 is more practical due to its better energy efficiency (at least for fueling station supply) and proven technology readiness.
Primary tumor volume as a predictor of distant metastases and survival in patients with sinonasal mucosal melanoma
Authors: Flukes Stephanie , Lohia Shivangi , Barker Christopher A. , Cracchiolo Jennifer R. , Ganly Ian , Patel Snehal G. , Roman Benjamin R. , Shah Jatin P. , Shoushtari Alexander N. , Tabar Viviane , Shah Akash , Cohen Marc A. 
Published: August 2020

AbstractBackgroundSinonasal mucosal melanoma (SNMM) is an aggressive cancer with high mortality. Identifying patients at risk of distant metastasis assists with management and prognostication. We aimed to define the relationship between volume, survival, and risk of distant metastases.MethodsA retrospective review of all patients with SNMM treated at a single institution over a 21‐year period was conducted. Tumor volume was calculated using cross‐sectional imaging and survival analysis was performed.ResultsSixty‐one patients were included. Tumor volume was predictive of local progression‐free survival (P = .03), distant metastases‐free survival (DMFS) (P = .002), and overall survival (OS) (P = .02). It was a better predictor than AJCC stage and T‐classification. Tumor volume equal to or greater than 5 cm3 was associated with a significantly worse DMFS and OS (P = .02 and .009, respectively).ConclusionCalculation of tumor volume assists in quantifying the risk of distant metastases and death in SNMM.
Expanded exposure and detailed anatomic analysis of the superior orbital fissure: Implications for endonasal and transorbital approaches
Authors: Li Lifeng , London Nyall R. , Chen Xiaohong , Prevedello Daniel M. , Carrau Ricardo L. 
Published: August 2020

AbstractThis study aimed to ascertain the maximal exposure of the superior orbital fissure (SOF) afforded by combining endonasal and transorbital endoscopic approaches. Six cadaveric specimens (12 sides) were dissected using endonasal and transorbital endoscopic approaches to access the SOF. The order of the approaches was alternated in each specimen (eg, starting with an endonasal approach in one side followed by a transorbital exposure and reversing the order on the contralateral side). Maximal exposure of the SOF and its contents for individual and combined approaches were explored. The endonasal corridor provided adequate access to the inferomedial 1/3 of the SOF and including the proximal segments of cranial nerves (CN) III, V1 and VI. A transorbital approach was superior accessing the superolateral 2/3's of the SOF, including the superior ophthalmic vein, lacrimal nerve, and distal segment of the CN VI at the lateral aspect; the nasociliary nerve and divisions of CN III centrally; and the frontal nerve and CN IV at the dorsal aspect of levator palpebrae superioris. This study suggests that a combined endonasal and transorbital exposure of the SOF may be advantageous to address lesions in this challenging region.
Prenatal Exposure to Perfluoroalkyl Substances Associated With Increased Susceptibility to Liver Injury in Children
Authors: Stratakis Nikos , V. Conti David , Jin Ran , Margetaki Katerina , Valvi Damaskini , Siskos Alexandros P. , Maitre Léa , Garcia Erika , Varo Nerea , Zhao Yinqi , Roumeliotaki Theano , Vafeiadi Marina , Urquiza Jose , Fernández‐Barrés Silvia , Heude Barbara , Basagana Xavier , Casas Maribel , Fossati Serena , Gražulevičienė Regina , Andrušaitytė Sandra , Uppal Karan , McEachan Rosemary R.C. , Papadopoulou Eleni , Robinson Oliver , Haug Line Småstuen , Wright John , Vos Miriam B. , Keun Hector C. , Vrijheid Martine , Berhane Kiros T. , McConnell Rob , Chatzi Lida 
Published: August 2020

Background and Aims
Per‐ and polyfluoroalkyl substances (PFAS) are widespread and persistent pollutants that have been shown to have hepatotoxic effects in animal models. However, human evidence is scarce. We evaluated how prenatal exposure to PFAS associates with established serum biomarkers of liver injury and alterations in serum metabolome in children.

Approach and Results
We used data from 1,105 mothers and their children (median age, 8.2 years; interquartile range, 6.6‐9.1) from the European Human Early‐Life Exposome cohort (consisting of six existing population‐based birth cohorts in France, Greece, Lithuania, Norway, Spain, and the United Kingdom). We measured concentrations of perfluorooctane sulfonate, perfluorooctanoate, perfluorononanoate, perfluorohexane sulfonate, and perfluoroundecanoate in maternal blood. We assessed concentrations of alanine aminotransferase, aspartate aminotransferase, and gamma‐glutamyltransferase in child serum. Using Bayesian kernel machine regression, we found that higher exposure to PFAS during pregnancy was associated with higher liver enzyme levels in children. We also measured child serum metabolomics through a targeted assay and found significant perturbations in amino acid and glycerophospholipid metabolism associated with prenatal PFAS. A latent variable analysis identified a profile of children at high risk of liver injury (odds ratio, 1.56; 95% confidence interval, 1.21‐1.92) that was characterized by high prenatal exposure to PFAS and increased serum levels of branched‐chain amino acids (valine, leucine, and isoleucine), aromatic amino acids (tryptophan and phenylalanine), and glycerophospholipids (phosphatidylcholine [PC] aa C36:1 and Lyso‐PC a C18:1).

Conclusions
Developmental exposure to PFAS can contribute to pediatric liver injury.
Targeted next‐generation sequencing reveals molecular heterogeneity in non‐chronic lymphocytic leukemia clonal B‐cell lymphocytosis
Authors: Defrancesco Irene , Zibellini Silvia , Boveri Emanuela , Frigeni Marco , Ferretti Virginia Valeria , Rizzo Ettore , Bonometti Arturo , Capuano Francesca , Candido Chiara , Rattotti Sara , Tenore Annamaria , Picone Cristina , Flospergher Elena , Zerbi Caterina , Bergamini Fabio , Fabbri Nicole , Cristinelli Caterina , Varettoni Marzia , Paulli Marco , Arcaini Luca 
Published: August 2020

AbstractNon‐chronic lymphocytic leukemia (non‐CLL) clonal B‐cell lymphocytosis (CBL) encompasses a heterogeneous group of hematologic disorders that are still poorly understood. To shed light on their biological aspects, we retrospectively analyzed a highly selected series of 28 patients, who had a clonal B‐cell population in the peripheral blood and in the bone marrow, without evidence of lymphoma. Extended targeted next‐generation sequencing revealed wide molecular heterogeneity with MYD88 (14%), PDE4DIP (14%), BIRC3 (11%), CCND3 (11%), NOTCH1 (11%), and TNFAIP3 (11%) as the most mutated genes. Mutations of MYD88 were “nonclassic” in most cases. Although some genetic lesions were overlapping with indolent lymphomas, mainly splenic B‐cell lymphomas of marginal zone origin and splenic diffuse red pulp small B‐cell lymphoma, the genetic profile of our non‐CLL CBL series seemed to suggest that various pathways could be involved in the pathogenesis of these disorders, not mirroring any specific lymphoma entity. These data better enlighten the molecular characteristics of non‐CLL CBL; however, more efforts are needed in order to improve the diagnostic process, prognostication, and clinical management.
First‐line pazopanib in intermediate‐ and poor‐risk patients with metastatic renal cell carcinoma: Final results of the FLIPPER trial
Authors: Staehler Michael , Panic Andrej , Goebell Peter J. , Merling Marie , Potthoff Karin , Herrmann Edwin , de Geeter Patrick , Vannier Corinne , Hogrefe Cathrin , Marschner Norbert , Grünwald Viktor 
Published: August 2020

AbstractTemsirolimus has long been the only approved first‐line standard of care (SOC) with overall survival (OS) benefit in poor‐risk patients with advanced or metastatic renal cell cancer (mRCC). However, tyrosine kinase inhibitors are also commonly used in clinical practice. Pazopanib is an SOC for first‐line mRCC treatment, but for poor‐risk patients data are scarce. The FLIPPER (First‐Line Pazopanib in Poor‐Risk Patients with Metastatic Renal Cell Carcinoma) study aimed to assess efficacy and safety of first‐line pazopanib in poor‐risk mRCC patients. FLIPPER was a single‐arm, multicenter, Phase IV trial. Key inclusion criteria were treatment‐naive clear cell, inoperable advanced or mRCC, poor‐risk according to MSKCC with slight modification, Karnofsky performance status (KPS) ≥60% and adequate organ function. Oral pazopanib 800 mg was given daily. Primary endpoint was the 6‐month progression‐free survival rate (PFS6). Secondary endpoints included PFS, OS, overall response rate (ORR), duration of response (DOR) and safety. For analysis, descriptive statistics were used. Between 2012 and 2016, 60 patients had been included. Forty‐three patients qualified for safety analyses, 34 for efficacy. Median age was 66 years, 64.7% of patients were poor‐risk, 82.4% had a KPS ≤70%. PFS6 was 35.3% (95% CI, 19.7‐53.5). Median PFS and OS were 4.5 months (95% CI, 3.6‐7.8) and 9.3 months (95% CI, 6.6‐22.2), respectively. ORR was 32.4% (95% CI, 17.4‐50.5), median DOR 9.7 months (95% CI, 1.8‐12.4). The most common treatment‐related grade 3/4 adverse event reported in 4.7% of patients was hypertension. No treatment‐related death occurred. Since pazopanib is active and well tolerated in poor‐risk patients with clear cell mRCC, our results support its use as first‐line treatment in this setting.
Machine learning model to predict oncologic outcomes for drugs in randomized clinical trials
Authors: Schperberg Alexander V. , Boichard Amélie , Tsigelny Igor F. , Richard Stéphane B. , Kurzrock Razelle 
Published: August 2020

AbstractPredicting oncologic outcome is challenging due to the diversity of cancer histologies and the complex network of underlying biological factors. In this study, we determine whether machine learning (ML) can extract meaningful associations between oncologic outcome and clinical trial, drug‐related biomarker and molecular profile information. We analyzed therapeutic clinical trials corresponding to 1102 oncologic outcomes from 104 758 cancer patients with advanced colorectal adenocarcinoma, pancreatic adenocarcinoma, melanoma and nonsmall‐cell lung cancer. For each intervention arm, a dataset with the following attributes was curated: line of treatment, the number of cytotoxic chemotherapies, small‐molecule inhibitors, or monoclonal antibody agents, drug class, molecular alteration status of the clinical arm's population, cancer type, probability of drug sensitivity (PDS) (integrating the status of genomic, transcriptomic and proteomic biomarkers in the population of interest) and outcome. A total of 467 progression‐free survival (PFS) and 369 overall survival (OS) data points were used as training sets to build our ML (random forest) model. Cross‐validation sets were used for PFS and OS, obtaining correlation coefficients (r) of 0.82 and 0.70, respectively (outcome vs model's parameters). A total of 156 PFS and 110 OS data points were used as test sets. The Spearman correlation (rs) between predicted and actual outcomes was statistically significant (PFS: rs = 0.879, OS: rs = 0.878, P < .0001). The better outcome arm was predicted in 81% (PFS: N = 59/73, z = 5.24, P < .0001) and 71% (OS: N = 37/52, z = 2.91, P = .004) of randomized trials. The success of our algorithm to predict clinical outcome may be exploitable as a model to optimize clinical trial design with pharmaceutical agents.
Viability of liberal professions' economic effectiveness in the context of the new fiscal changes in Romania
Authors: Antohi Valentin M. , Zlati Monica L. , Radu Riana I. , Cosmulese Cristina G. , Socoliuc Marian 
Published: August 2020

AbstractIn the current economic flow generated context, the services provided by liberal professions have become a link between producers and suppliers of products, services and end‐users. The objective of the study is to delineate the fiscal debt sustainability threshold and its impact on liberal professions specific activities. A subsequent objective is to highlight the impact of the independent activities of the liberal professions at the micro and macroeconomic level by developing a model of circular interdependence, between the inputs and outputs of resources, services and the critical point from which it can produce value, continuity and growth in activity. The results of the study are based on the definition of the role of the liberal profession in the context of the current economy in Romania, as well as on the demarcation of the critical point from which the economic spiral can create added value and profitability.
The macroeconomics of gender equality
Authors: Ghosh Taniya , Ramanayake Sanika S. 
Published: August 2020

AbstractThis study investigates the association between gender gap and economic progress. Using a panel VAR study as well as a comprehensive gender gap index and its sub‐indices from the World Economic Forum, the study confirms the existence of bidirectional Granger causality between gender gap and economic progress, for OECD countries and developing countries. On the one hand, economic progress encourages equity for both sexes. On the other hand, gender equity helps developing nations prosper and significantly improve their human capital, which, in turn, drives long‐run economic progress. By contrast, closing the gender gap negatively affects OECD output. For the sample of developing countries, the aforementioned results are robust to sub‐indices measured by gender gap in economic participation as well as opportunity, educational attainment, and political empowerment. We recommend that gender policies specifically aim at eliminating gaps in female education.
An empirical examination of purchasing power parity: Argentina 1810–2016
Authors: Jacobo Alejandro D. , Sosvilla‐Rivero Simón 
Published: August 2020

AbstractThis paper examines the purchasing power parity behaviour for Argentina during the 1810–2016 period. To that end, we use cointegration analysis and error correction models allowing for structural breaks. We find a long‐run relationship between the AR$/USD exchange rate and the price differential between Argentina and the USA. In particular, we offer empirical evidence in favour of a cointegrating equation with two structural breaks. We also find evidence that the data could identify an appropriate error correction model for the short‐run dynamics, hence providing further support for the cointegrating equation as a long‐run relationship.
The spillover effects of economic policy uncertainty on the oil, gold, and stock markets: Evidence from China
Authors: Gao Ruzhao , Zhao Yancai , Zhang Bing 
Published: August 2020

AbstractIn this study, we investigate the different spillover levels of economic policy uncertainty (EPU) on the oil, gold, and stock markets in China. EPU has the highest levels of the growth and volatility spillover on the gold market, and EPU transmits the lowest levels of growth and volatility spillovers to the oil market. EPU receives the highest level of return spillover from the oil market and the lowest from the gold market. However, EPU receives a higher level of the volatility spillover from the gold and stock markets. Regarding growth spillover, EPU is the net spillover receiver from the oil market and the net spillover transmitter to the gold market. Regarding volatility spillover, EPU is a main spillover receiver from all three markets. All net spillovers from EPU to the oil, gold, and stock markets are time‐varying. The recent financial crisis exerts significant effects on the net spillovers of EPU on the three markets.
Asymmetric cointegration, Non‐linear ARDL, and the J‐curve: A bilateral analysis of Pakistan and its trading partners
Authors: Iqbal Javed , Nosheen Misbah , Rehman Panezai Gauhar , Salahuddin  
Published: August 2020

AbstractEarlier studies that investigated the response of the trade balance to exchange rate changes relied on the assumption that appreciations and depreciation behaves in symmetric way and have used the linear ARDL approach for empirical estimates. The empirical results are supposed to have masked by restricted assumption of symmetry between exchange rate and trade balance. In this study, we investigate the J‐curve at the bilateral level between Pakistan and her major eight trading partners. We find significant evidence that non‐linear Autoregressive Distributive lag (ARDL) Model performs better as compared to linear ARDL. In case of linear ARDL, there is no evidence of the J‐curve at bilateral level, however, when we used non‐linear ARDL, we found the support of the J‐curve in the case of Malaysia, China, and the United States.
The role of information and communication technology (internet penetration) on Asian stock market efficiency: Evidence from quantile‐on‐quantile cointegration and causality approach
Authors: Afshan Sahar , Sharif Arshian , Nassani Abdelmohsen A. , Abro Muhammad M. Q. , Batool Rubeena , Zaman Khalid 
Published: August 2020

AbstractThe objective of the study is to evaluate the long‐run and causal relationship between information and communication technology (ICT) and Asian stock market efficiency by using quantile‐on‐quantile cointegration and causality approach, which analysed the different slope coefficients at median and the lower tails of conditional quantiles distribution. The study selected 10 Asian countries that experienced massive capital flows and e‐financing to verify efficient market hypothesis. The study utilizing a monthly time series data ranging from 2000 M01 to 2016 M12, where pre‐ and post‐global financial crisis time period is certainly induced, which affected through trade and financial channels in many Asian countries. The results confirmed the positive linkages between stock market efficiency and internet use in the 8 Asian countries while this result is averted in the two Asian countries (i.e., China and Russia) in a given time period. The heterogeneity between the countries in the stock‐ICT nexus could be endorsed to the multiple factors that need to be included in the multivariate framework.
Exploring the dynamic price discovery, risk transfer and spillover among INE, WTI and Brent crude oil futures markets: Evidence from the high‐frequency data
Authors: Zhang Yue‐Jun , Ma Shu‐Jiao 
Published: August 2020

AbstractIn order to test whether Chinese crude oil futures (INE) has already played the role of futures market and whether it has had a significant impact on international benchmark market, we construct the permanent temporary model and Information Share model based on 15 min of high‐frequency trading data from March 26, 2018 to October 30, 2018 to inspect the proportions of new information in INE and Brent markets, and use the Garbade‐Silber model to measure the risk transfer effect. Furthermore, the generalised spillover index is proposed to examine the effects of return and volatility spillovers among INE, WTI and Brent futures markets. The results reveal that: firstly, during the sample period, INE is not yet a promoter of international benchmark crude oil prices, but more obvious followers. Secondly, although INE has begun to display the price discovery function, it is weaker than that of Brent, and the risk transfer function between them does not appear strong. Finally, INE market mainly acts as a net transmitter of return spillover before August 2018, but it has almost always been the net transmitter of volatility spillover during the full sample period. These findings are of interest to policy makers as well as investors for risk hedging and asset allocation of crude oil portfolios.
Information content of insider filings after stock repurchase and seasoned equity issue announcements
Authors: Huang Han‐Ching , Tung Pei‐Shan 
Published: August 2020

AbstractThis paper examines the information content of insider filings after stock repurchase and seasoned equity issue (SEOs) announcements. We find that when firms and insiders trade in the same directions, the absolute value of the market reaction to insiders' purchase filings after stock repurchase announcements is larger than that to insiders' sale filings after SEO announcements. Thus, although insiders' sale filings after SEO announcements still suggest that the stocks are overvalued, the signals may be less informative owing to the confounding effect of some insiders' liquidity needs. When the firms and insiders trade in opposite directions, insiders' purchases after a firm's sale dominate insiders' sales after a firm's purchase, since insiders' purchase always convey positive information about a firm's future. When the firms and insiders trade in the same direction, the abnormal returns following purchases (or sales) depend on the type of insiders who make the trade. The positive (negative) abnormal returns following purchases (sales) decrease in absolute value according to the category of insiders, which is consistent with the information hierarchy hypothesis. When firms and insiders trade in opposite directions, the results are similar, but the magnitude is weak. Based on our results, the insiders who are more familiar with the day‐to‐day operations of the firm would trade on more valuable information than other insiders. Although following CEO trades more closely results in CEOs trading more cautiously, CEOs face less litigation risk and trade more on their informational advantages after event announcements.
Firm financial performance during the financial crisis: A French case study
Authors: Ben Jabeur Sami , Belhaj Hassine Rabi , Mefteh‐Wali Salma 
Published: August 2020

AbstractThis study investigates the effect of the 2008 financial crisis on the corporate performance of 805 French firms over the period of 2007–2009. This research uses both ordinary least squares (OLS) and fuzzy set qualitative comparative analysis (fsQCA) to estimate this relationship. The OLS results show no impact of the regional gross domestic product per capita on profitability, whereas the fsQCA suggests several paths for corporate performance. The study offers two principal contributions. Firstly, it takes into account region specificities to assess the impact of the financial crisis on firm performance. Secondly, the study combines an innovative analytical approach, fsQCA, with multivariate regression analysis to analyse firm performance.