bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of chitosan combined with ε‐polylysine coating on flavor and texture quality of Chinese shrimp during refrigerated storage
Authors: Zhang Zhen , Huang Yunpo , Guo Xuesong , Meng Xin , Wu Handong , Guo Fang , Zhang Shu‐ai , Li Dandan 
Published: February 2020

AbstractWe investigated the effects of chitosan (CH) combined with ε‐polylysine (ε‐PL) on the flavor and texture quality of Chinese shrimp refrigerated for 12 days. Shrimp samples were subjected to three preservation treatments (ε‐PL, CH, and CH + ε‐PL) and a control treatment. Sensory characteristics, total volatile basic nitrogen (TVB‐N), adenosine triphosphate (ATP)‐related compounds, K‐values, volatile components, and texture were regularly assessed. The results showed that the sensory characteristics were effectively maintained, the increases in TVB‐N, hypoxanthine, and K‐value were delayed, and the putrid compounds were reduced by coating, especially with the chitosan combined with ε‐polylysine. Treatment with chitosan combined with ε‐polylysine was also shown to be a more effective preservation method for maintaining the texture quality of Chinese shrimp compared to treatment with ε‐PL or CH alone. Therefore, this technique was demonstrated to be a promising method for maintaining the flavor and texture quality of Chinese shrimp during refrigerated storage.
A novel double‐doped polymer‐modified cement‐based sealant to enhance borehole seals and reduce methane emissions
Authors: Zhou Aitao , Wang Jiawen , Wang Kai , Elsworth Derek , Zhang Meng 
Published: February 2020

AbstractThis study was conducted to develop a new type of sealing material: double‐doped polymer‐modified cement‐based sealant (DPCS) and to verify its sealing performance. The aim is to improve the sealing effect of borehole, improve the gas extraction efficiency, and reduce methane emissions. Two kinds of polymers are doped in DPCS, namely the water‐soluble polymer emulsion (A1) and the cationic polymer (A2). The fluidity, expansion, compactness, and mechanical properties of DPCS and the single‐doped polymer‐modified sealant were tested and compared. Additionally, the effects of the polymer–cement ratio and the dispersant dosage on the sealing performance of DPCS were analyzed. To evaluate these competing effects of multiple factors on sealing performance of DPCS comprehensively, an orthogonal test was designed with range and variance analyses. The results show that with a polymer–cement ratio of 6%, 0.10% expansion agent dosage, and 1.2% dispersant dosage, the DPCS performs best on mechanical and expansion properties. A field site test at the working face 15201 of the Baiyangling coal mine was conducted to verify DPCS's sealing performance. The test results indicate that the novel DPCS can improve the concentration of extracted gas, and is also a better choice than the common sealing materials used in the mine economically. © 2020 Society of Chemical Industry and John Wiley & Sons, Ltd.
Temporal cues trick the visual and auditory cortices mimicking spatial cues in blind individuals
Authors: Gori Monica , Amadeo Maria Bianca , Campus Claudio 
Published: February 2020

AbstractIn the absence of vision, spatial representation may be altered. When asked to compare the relative distances between three sounds (i.e., auditory spatial bisection task), blind individuals demonstrate significant deficits and do not show an event‐related potential response mimicking the visual C1 reported in sighted people. However, we have recently demonstrated that the spatial deficit disappears if coherent time and space cues are presented to blind people, suggesting that they may use time information to infer spatial maps. In this study, we examined whether the modification of temporal cues during space evaluation altered the recruitment of the visual and auditory cortices in blind individuals. We demonstrated that the early (50–90 ms) occipital response, mimicking the visual C1, is not elicited by the physical position of the sound, but by its virtual position suggested by its temporal delay. Even more impressively, in the same time window, the auditory cortex also showed this pattern and responded to temporal instead of spatial coordinates.
Do payor‐based outreach programs reduce medical cost and utilization?
Authors: Ukert Benjamin , David Guy , Smith‐McLallen Aaron , Chawla Ravi 
Published: February 2020

ABSTRACTThere is growing interest in using predictive analytics to drive interventions that reduce avoidable healthcare utilization. This study evaluates the impact of such an intervention utilizing claims from 2013 to 2017 for high‐risk Medicare Advantage patients with congestive heart failure. A predictive algorithm using clinical and nonclinical information produced a risk score ranking for health plan members in 10 separate waves between July 2013 and May 2015. Each wave was followed by an outreach intervention. The varying capacity for outreach across waves created a set of arbitrary intervention treatment cutoff points, separating treated and untreated members with very similar predicted risk scores. We estimate a difference‐in‐differences model to identify the effects of the intervention program among patients with a high score on care utilization. We find that enrollment in the intervention decreased the probability and number of hospitalizations (by 43% and 50%, respectively) and emergency room visits (10% and 14%, respectively), reduced the time until a primary care visit (8.2 days), and reduced total medical cost by $716 per month in the first 6 months following outreach.
Outcomes after eye‐sparing surgery vs orbital exenteration in patients with lacrimal gland carcinoma
Authors: Bonavolontà Paola , Esmaeli Bita , Donna Piero , Tranfa Fausto , Iuliano Adriana , Abbate Vincenzo , Fossataro Federica , Attanasi Federica , Bonavolontà Giulio 
Published: February 2020

AbstractBackgroundThis study examined whether eye‐sparing surgery is associated with better or worse outcomes than exenteration for the treatment of lacrimal gland carcinomas.MethodsForty‐six patients treated for lacrimal gland carcinoma were retrospectively reviewed and compared. A statistical analysis was performed using Kaplan‐Meier plots.ResultsThe overall survival rates for eye‐sparing surgery were 52% and 37% at 5 and 10 years, and those for exenteration were 37% and 25% at 5 and 10 years, respectively (P = .73). The proportion of patients with local regional control at both 5 and 10 years after eye‐sparing surgery was 0.75, and that for exenteration was 0.47 (P = .30). For eye‐sparing surgery, the proportions of distant metastasis‐free survival at 5 and 10 years were 0.51 and 0.39 for eye‐sparing surgery and 0.29 and 0.14 for exenteration (P = .50).ConclusionBecause the outcomes were not significantly different, the authors suggest that eye‐sparing surgery can be proposed as a reasonable approach for lacrimal gland carcinomas in appropriately selected patients.
Prevalence of carotid stenosis following radiotherapy for head and neck cancer: A systematic review and meta‐analysis
Authors: Texakalidis Pavlos , Giannopoulos Stefanos , Tsouknidas Ioannis , Song Shiyu , Rivet Dennis J. , Reiter Evan R. , Reavey‐Cantwell John 
Published: February 2020

AbstractBackgroundRadiation to the head and neck is a well‐established risk factor for the development of carotid artery stenosis. Our objective was to identify the prevalence, incidence, and degree of carotid stenosis in patients with a history of head and neck irradiation.MethodsThis study was performed according to the PRISMA guidelines. A random effects model meta‐analysis was conducted.ResultsNineteen studies comprising 1479 patients were included. The prevalence of carotid stenosis >50%, >70%, and carotid occlusion was 25% (95% CI: 19%‐32%), 12% (95% CI: 7%‐17%), and 4% (95% CI: 2%‐8%), respectively. The cumulative 12‐month incidence of carotid stenosis >50% was 4% (95% CI: 2%‐5%), the 24‐month was 12% (95% CI: 9%‐15%), and the 36‐month was 21% (95% CI: 9%‐36%).ConclusionsThe yearly incidence of carotid stenosis >50% increased every year during the first 3 years following radiotherapy. We propose routine yearly Doppler ultrasound screening beginning 1 year after head and neck radiotherapy.
Deletion of Protein Kinase D3 Promotes Liver Fibrosis in Mice
Authors: Zhang Shuya , Liu Huan , Yin Meimei , Pei Xiuying , Hausser Angelika , Ishikawa Eri , Yamasaki Sho , Jin Zheng Gen 
Published: February 2020

Background and Aims
Liver fibrosis (LF) is a central pathological process that occurs in most types of chronic liver diseases. Advanced LF causes cirrhosis, hepatocellular carcinoma, and liver failure. However, the exact molecular mechanisms underlying the initiation and progression of LF remain largely unknown.

Approach and Results
This study was designed to investigate the role of protein kinase D3 (PKD3; gene name Prkd3) in the regulation of liver homeostasis. We generated global Prkd3 knockout (Prkd3−/−
) mice and myeloid‐cell–specific Prkd3 knockout (Prkd3
∆LysM) mice, and we found that both Prkd3−/−
mice and Prkd3∆LysM
mice displayed spontaneous LF. PKD3 deficiency also aggravated CCl4‐induced LF. PKD3 is highly expressed in hepatic macrophages (HMs), and PKD3 deficiency skewed macrophage polarization toward a profibrotic phenotype. Activated profibrotic macrophages produced transforming growth factor beta that, in turn, activates hepatic stellate cells to become matrix‐producing myofibroblasts. Moreover, PKD3 deficiency decreased the phosphatase activity of SH2‐containing protein tyrosine phosphatase‐1 (a bona‐fide PKD3 substrate), resulting in sustained signal transducer and activator of transcription 6 activation in macrophages. In addition, we observed that PKD3 expression in HMs was down‐regulated in cirrhotic human liver tissues.

Conclusions
PKD3 deletion in mice drives LF through the profibrotic macrophage activation.
How are Victorian Local Governments' responding to climate change and food insecurity?
Authors: Beaudry Emily , McKay Fiona H. , Haines Bronte C. 
Published: February 2020

AbstractIssue addressedClimate change is one of the greatest challenges to public health and well‐being. Steps taken by governments now will have a significant effect on public health outcomes, including the food system and food security.MethodThis study reviewed municipal public health and well‐being plans from 79 local government areas (LGAs) in Victoria, Australia. Documents were included if they explicitly mentioned climate change and food insecurity. Of the 79 LGAs, 13 met the selection criteria and a content and framing analysis was conducted to identify the level of recognition of climate change on food security and proposed mitigation actions and strategies.ResultsOf the 13 LGAs, the documents of six were identified as having a high level of responsiveness to climate change and food insecurity, five were assessed as medium and two low. Framing analysis identified council acknowledgment of how climate change effects food access through availability and price, and growing food locally and sustainably is seen as a common action to improve food security.ConclusionThe findings of this study suggest that planning for climate change and food insecurity is not a high priority for Victorian LGAs. Given the current political climate in Australia, where many in federal government continue to deny the existence of climate change or are reluctant to implement mitigation strategies, it is now and will be increasingly important into the future that local governments plan for the impact of climate change on food insecurity.So what?Climate change will impact how people access food and what foods are available to them. Unless all levels of government start to address and plan for climate change, the impact on communities will continue to intensify and grow more costly and damaging.
The effects of offering flexible work practices to employees with unpaid caregiving responsibilities for elderly or disabled family members
Authors: Bainbridge Hugh T. J. , Townsend Keith 
Published: February 2020

AbstractApproximately one in 10 employees in Australia, the United States, and Europe have unpaid caregiving responsibilities for elderly or disabled family members. This combination of employment and caregiving roles is problematic when there is conflict between their simultaneous demands. Flexible work practices can be an important mechanism for assisting these employees. However, limited attention has been given to determining the benefits of flexible work practices for these employees, or the process by which these effects arise. We address these gaps via a survey of employees with unpaid caregiving responsibilities for family who are elderly or disabled. Results indicate that greater availability of flexible work practices improves perceptions of workplace support for combining caregiving and employment. This effect was partially and sequentially mediated by disclosure, practice utilization, and practice helpfulness. Additionally, practice availability had a direct positive effect on practice utilization, while disclosure had a direct positive effect on perceived support. Overall, the findings demonstrate the benefits of flexible work practices for employees with caregiving responsibilities. The study also points the way to interventions that can improve the effectiveness of flexible work practices by demonstrating how the potential benefits of these practices are translated into actual improvements in perceived support.
Ecological Risks of Metal and Metalloid Contamination in the Rio Doce Estuary
Authors: Gabriel Fabrício A , Silva André G , Queiroz Hermano M , Ferreira Tiago O , Hauser-Davis Rachel A , Bernardino Angelo F 
Published: February 2020

Abstract
The rupture of a mining dam in southeastern Brazil in 2015 was the country's greatest environmental tragedy. In order to evaluate the ecological risks of the mine tailings on the Rio Doce estuary, this study assessed trace metal contamination and sediment quality indices up to 2.9 y after the dam rupture. Surface sediments were collected from 17 stations on the Rio Doce estuary and Cd, Pb, Cr, Zn, Cu, and As concentrations were determined by inductively coupled plasma atomic emission spectroscopy (ICP-OES). Four ecological risk indices (modified contamination degree [mCd], pollution load index [PLI], risk index [RI], and sediment quality guideline quotient [SQG-Q]) suggest a high risk by metal contamination with possible adverse biological effects, with moderate seasonal variability. Based on a precautionary approach, our results support fisheries closures and the need for public health monitoring in the affected areas, and support other studies that suggest chronic metal contamination of the Rio Doce estuary. Integr Environ Assess Manag 2020;16:655–660. © 2020 SETAC
Relationships Among Bone Morphological Parameters and Mechanical Properties of Cadaveric Human Vertebral Cancellous Bone
Authors: Al‐Barghouthi Abeer , Lee Seokgi , Solitro Giovanni Francesco , Latta Loren , Travascio Francesco 
Published: February 2020

ABSTRACTMechanical properties and morphological features of the vertebral cancellous bone are related to resistance to fracture and capability of withstanding surgical treatments. In particular, vertebral strength is related to its elastic properties, whereas the ease of fluid motion, related to the success of incorporation orthopedic materials (eg, bone cement), is regulated by the hydraulic permeability (K). It has been shown that both elastic modulus and permeability of a material are affected by its morphology. The objective of this study was to establish relations between local values of K and the aggregate modulus (H), and parameters descriptive of the bone morphology. We hypothesized that multivariate statistical models, by including the contribution of several morphology parameters at once, would provide a strong correlation with K and H of the vertebral cancellous bone. Hence, μCT scans of human lumbar vertebra were used to determine a set of bone morphology descriptors. Subsequently, indentation tests on the bone samples were conducted to determine local values of K and H. Finally, a multivariate approach supported by principal component analysis was adopted to develop predictive statistical models of bone permeability and aggregate modulus as a function of bone morphology descriptors. It was found that linear combinations of bone volume fraction, trabecular thickness, trabecular spacing, structure model index, connectivity density, and degree of anisotropy provide a strong correlation (R2 ~ 76%) with K and a weaker correlation (R2 ~ 47%) with H. The results of this study can be exploited in computational mechanics frameworks for investigating the potential mechanical behavior of human vertebra and to develop strategies to treat or prevent pathological conditions such as osteoporosis, age‐related bone loss, and vertebral compression fractures. © 2020 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.
Comparison of pancreaticoduodenectomy and bile duct resection for middle bile duct cancer: A multi‐center collaborating study of Japan and Korea
Authors: Hayashi Hiroki , Jang Jin‐Young , Kim Kyung Sik , Choi Jin Sub , Takahara Takeshi , Choi Sung Hoon , Hirano Satoshi , Yu Hee Chul , Uemura Syuichiro , Unno Michiaki 
Published: February 2020

AbstractBackgroundIt is currently unknown whether bile duct segmental resection (BDSR) is an acceptable method for localized middle bile duct cancer (mid‐BDC) when R0 resection can be achieved. This study aimed to investigate the short‐ and long‐term outcomes of mid‐BDC patients treated with pancreaticoduodenectomy (PD) compared to those for BDSR.MethodsThis was a retrospective, Japanese and Korean multi‐center collaboration study based on patients' medical records.ResultsA total of 663 patients, including 245 BDSR and 418 PD cases, were enrolled. The incidence of postoperative pancreatic fistula (3.3% vs 44.1%, P < .0001), surgical site infection in the organ space (6.1% vs 17.7%, P < .0001) and clinically problematic morbidities (15.9% vs 32.8%, P < .0001) was significantly higher in the PD group. There was no difference in the mortality rate (0.8% vs 1.7%, P = .3566). Local (33.9% vs 14.4%, P < .0001) and lymph node (22.4% vs 11.0%, P < .0001) recurrence rates were significantly higher in the BDSR group. Relapse‐free survival (25.0 vs 34.0 months, P = .0184) and overall survival (41.2 vs 60.1 months, P = .0019) were significantly longer in the PD group. The PD group had significantly better prognosis in stage IA/IB cases (58.3 vs 111.5 months, P = .0067), which were the best indicators for BDSR, even when R0 resection was achieved. In multivariate analysis, BDSR was an independent poor prognostic factor.ConclusionDespite the inferior perioperative short‐term outcomes, our data advocate that PD should be the standard procedure for mid‐BDCs and that BDSR should be avoided even if R0 resection can be achieved. (UMIN000017914).
Lipid Use in Hospitalized Adults Requiring Parenteral Nutrition
Authors: Mayer Konstantin , Klek Stanislaw , García‐de‐Lorenzo Abelardo , Rosenthal Martin D. , Li Ang , Evans David C. , Muscaritoli Maurizio , Martindale Robert G. 
Published: February 2020

AbstractIn hospitalized patients, lipid emulsions are an integral part of balanced parenteral nutrition. Traditionally, a single lipid source, soybean oil, has been given to patients and was usually regarded as just a source of energy and to prevent essential fatty‐acid deficiency. However, mixtures of different lipid emulsions have now become widely available, including mixtures of soybean oil, medium‐chain triglycerides, olive oil, and fish oil. Fish oil is high in the ω‐3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). There is a growing body of evidence that these ω‐3 fatty acids can exert beneficial immunomodulatory, anti‐inflammatory, and inflammation‐resolution effects across a wide range of patient groups including surgical, cancer, and critically ill patients. At least in part, these effects are realized via potent specialized pro‐resolution mediators (SPMs). Moreover, parenteral nutrition including ω‐3 fatty acids can result in additional clinical benefits over the use of standard lipid emulsions, such as reductions in infection rates and length of hospital and intensive care unit stay. Clinical and experimental evidence is reviewed regarding lipid emulsion use in a variety of hospitalized patient groups, including surgical, critically ill, sepsis, trauma, and acute pancreatitis patients. Practical aspects of lipid emulsion use in critically ill patients are also considered, such as how to determine and fulfill energy expenditure, how and when to consider parenteral nutrition, duration of infusion, and safety monitoring.
Osteoporosis and Hepatic Steatosis: 2 Closely Related Complications in Short‐Bowel Syndrome
Authors: Parreiras‐e‐Silva Luciana T. , de Araújo Iana M. , Elias Jorge , Nogueira‐Barbosa Marcello H. , Suen Vivian M. M. , Marchini Julio S. , Salmon Carlos E.G. , de Paula Francisco José Albuquerque 
Published: February 2020

AbstractBackgroundOsteoporosis has scarcely been prospectively investigated in short‐bowel syndrome (SBS). This prospective study was designed to evaluate incretins, adipokines, bone mass, and lipid deposits from marrow adipose tissue (MAT), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and liver (IHLs).MethodsThe study comprised 2 groups matched by gender, height, and age: the control group (CG) (9 males, 9 females) and the SBS group (SBSG) (6 males, 5 females). The SBSG was evaluated twice in an interval of 1 year (SBSG0and SBSG1). The biochemical evaluation included incretins, leptin, and adiponectin. Dual‐energy x‐ray absorptiometry and magnetic resonance were, respectively, used to measure BMD and lipid deposits.ResultsBone mineral density (BMD) was lower in the SBSG than in the CG, but there was no difference between SBSG0and SBSG1. There was no difference in MAT, SAT, and VAT, but IHL was lower in CG than in SBSG0and SBSG1. A negative correlation between MAT and third lumbar vertebrae BMD was found in the CG but not in SBSG0or SBSG1. There was a negative association between IHL and bone mass considering all participants (CG and SBSG0) (R2= 0.38;P< .05).ConclusionAppropriate nutrition assistance recovers body composition, reverts the relationship of bone mass and MAT, and mitigates bone loss in SBS. In spite of this, osteoporosis seems to be an early and persistent complication in SBS. Curiously, SBS seems to be a highly vulnerable condition for the development of hepatic steatosis and shows an association between bone mass and IHL.