bluuebunny/crossref_metadata_2025_split huggingface dataset:
The perspective of capability providers in creating a sustainable I4.0 environment
Authors: Lardo Alessandra , Mancini Daniela , Paoloni Niccolò , Russo Giuseppe 
Published: July 2020

PurposeWith the increasing pressures towards global sustainability and the transition to Industry 4.0 (I4.0), the collaboration between firms and other key stakeholders is essential. Value is no longer created by firms acting autonomously, but rather by firms acting together with external parties. Therefore, the aim of this study is to explore the potential contribution of capability providers to a Sustainable I4.0 Environment as an additional perspective regarding the management decisions of a smart and sustainable business model (SSBM) transformation of big corporations.Design/methodology/approachAn in-depth qualitative case study of Futuryng INC., which is a company based in Silicon Valley, New York and Italy, is presented and analysed through interviews, secondary sources and using a triangulation approach. The company is a Connected Technologies Ecosystem, which acts as a provider of technology building blocks (capability) able to design and release end-to-end Information Technologies–Internet of Things–Operational Technologies (IT-IoT-OT) Solutions.FindingsFrom the case study, the authors determine that the success of big corporations' SSBM transformation requires a Sustainable I4.0 Environment approach where capability providers play a relevant role and act as enablers. Then, the authors develop a framework by adopting an actor perspective, called the Sustainable I4.0 Environment, highlighting the contribution of the capability provider in the sustainable I4.0 business model transformation of a big corporation.Practical implicationsThe authors’ analysis clarifies that the successful execution of a sustainable I4.0 business model transformation requires integrated thinking for management decisions and a co-creation approach with capability providers, along with an open innovation process.Originality/valueIn the analysis of I4.0 and sustainability issues, previous studies only focus on implementing firms and view the environment merely as a background in which act forces of sustainability and I4.0. A comprehensive overview of the Sustainable I4.0 Environment, which considers actors and their contribution, is lacking. By integrating the literature review with the case study, the authors’ research proposes a comprehensive framework to guide the decision process of transformation from a traditional business model (TBM) to an SSBM and considers one of the key actors involved, the capability providers.
Belief in importance of information literacy abilities among undergraduates. Underlying factors and analysis of variance
Authors: Pinto Maria , Caballero David , Sales Dora , Segura Alicia 
Published: July 2020

PurposeThe purpose of this paper is to analyse the levels of belief in importance of information literacy abilities (BILAs) among an undergraduates’ sample. The aim is, on the one hand, to discover if there is a representative latent structure and, on the other hand, to know the existing differences according to external variables such as academic degree, course, gender and age.Design/methodology/approachA self-assessment questionnaire (IL-HUMASS) was applied to a sample of 749 students in English Studies, Translation and Interpreting and Education in Spain. Three types of statistical methods have been used to study the results: descriptive, factorial and analysis of variance.FindingsStudents’ levels of BILAs are acceptable but improvable. A framework of six underlying factors has been uncovered: evaluation-ethics, searching-using, technological processing, communication, dissemination and cognitive processing of the information. Significant differences on degree, course and gender have been found.Practical implicationsThis paper is intended for a broad academic sector, including faculty, librarians and students in higher education. The BILAs construct helps to improve the diagnosis of the perception of the BILAs. Its representation through a reduced number of latent factors simplifies results and possible applications. The results show that variations in degree, course and gender are significant and should be taken into account.Originality/valueAlthough much has been written about information literacy abilities, we still know little about the importance students place on them. The BILAs construct is intended to improve that knowledge.
Sustainable outcomes: INS/IEO and the relevance of proximity and control to drive change
Authors: Barter Nick , Alston-Knox Clair 
Published: July 2020

PurposeThis study aims to explore and develop new theories. These theories emerged from combining environmental psychology literature with sustainability literature and the five research questions at the core of the work built upon a central theme of sustainability that argues us and the organizations require a relationship of entwinement rather than separation and the language can reinforce or diminish the path to sustainable outcomes.Design/methodology/approachThe study used an electronic questionnaire to explore five research questions. The study consisted of survey individuals from across the world on their connection with nature using the inclusion of nature in self scale (Schultz, 2002). An adaptation of this scale called the inclusion of environment in organization scale to understand individuals’ views of their organization and then three pairs of questions that had alternative phrasing within each pair.FindingsIn total, 632 respondents from across the globe responded to the survey. The results highlight that respondents consider their organization’s conceptual relationship with the environment as far from ideal for sustainable outcomes and that their organization is out of synch with them personally. Further, respondents believe that asking a question that emphasizes proximity and control such as “would I want to breathe this”? is more likely to yield sustainable outcomes than an alternative phrasing that does not emphasize proximity and control, phrasing such as “do the gaseous outputs meeting regulation requirements”?Research limitations/implicationsGiven the study was exploratory the number and range of respondents ensure the study has a perspective, that is useful to organizational leaders and academics in exploring new directions. However, at the same time given the exploratory nature of the work, more studies are required to understand the “why” of respondents’ choices and to more fully develop and understand the implications of a wider range of alternatively phrased questions (only three were tested) that emphasize proximity and control such as that shown earlier “would I want to breathe this”?Practical implicationsFor organizational leaders, the research highlights that respondents view their organizations as being far from ideal in realizing sustainable outcomes, which, in turn, should be a spur to do more. Further, it indicates that simple phrasing that emphasizes proximity and control could be a tactic in helping an organization pursue sustainable strategies. For academics, the results of this study point us towards phraseology, as a key technique for helping drive organizational strategy towards sustainable outcomes.Social implicationsSee prior implicationsOriginality/valueThe value of this work is that it combines environmental psychology with sustainability management and provides a foundation and confidence for scholars and practitioners to explore the potential of new theories and thus follow new lines of enquiry.
A brief history of British drug policy: 1850-1950
Authors: Yates Rowdy 
Published: July 2020

Purpose
As the clamour within the drug treatment field in the UK – and throughout much of Europe – increases, leading agencies are arguing for a review of the current legislation and a change in focus away from criminal justice and towards a more public health understanding of addiction. Therapeutic communities have found themselves united with many drug users-led campaigns to argue for a wholesale restructuring of the legislative, policy and funding arrangements which recognises the role of recovery-oriented interventions within the mix. Given these on-going debates, it is perhaps useful to understand how the current arrangements were established [1].

Design/methodology/approach
In 1850s, the sale of opium – like alcohol – was largely unregulated. It was widely used, in a variety of preparations, by all classes for medical and non-medical purposes. A pennyworth of opium was as likely (perhaps more likely) as a pound of potatoes to find its way into the weekly shopping basket.

Findings
By the 1920s, the Fu Manchu novels of Sax Rohmer – with their tales of innocent English virgins being seduced into crime and sexual perversion by an evil Chinese genius who lurked within the opium dens of Edwardian Britain – had redefined opium as a drug of the outside, the deadly, an agent in the enslavement of innocence.

Originality/value
This dramatic change was largely brought about by the introduction of an array of new medications and a move away from traditional “herbal” remedies. This change was accelerated by the experiences of the First World War and underpinned by the print media and laid the foundations of the legislation and policy of the present day.
Digital ambidexterity in the public sector: empirical evidence of a bias in balancing practices
Authors: Magnusson Johan , Päivärinta Tero , Koutsikouri Dina 
Published: July 2020

PurposeThe purpose of this study is to explore and theorize on balancing practices (BP) for digital ambidexterity in the public sector.Design/methodology/approachThe research is designed as an interpretative case study of a large Swedish authority, involving data collection in the form of interviews and internal documents. The method of analysis involves both theorizing on the findings from a previous framework for digital innovation and deriving design implications for ambidextrous governance.FindingsThe findings show that all identified BP except one (shadow innovation) is directed toward an increased emphasis on efficiency (exploitation) rather than innovation (exploration). With the increased demand for innovation capabilities in the public sector, this is identified as a problem.Research limitations/implicationsThe limitations identified are related to the choice in the method of an interpretative case study, with issues of transferability and empirical generalizability as the main concerns. The implications for research are related to a need for additional studies into the enactment of digital ambidexterity, where the findings offer insight and inspiration for continued research.Practical implicationsThe study shows that managers and executives involved in the design and imposition of governance within the public sector need to take the design recommendations for digital ambidexterity into consideration.Social implicationsThe study offers two main implications for practice. First, policymakers need to take the conceptual distinction of efficiency and innovation into account when designing policies for the digital government. Second, existing funding practices need to be re-designed to better facilitate innovation.Originality/valueThis is the first study directed toward enhancing the insight into BP for digital ambidexterity in the public sector. The study has so far resulted in both a localized shift in policy and new directions for research. With the public sector facing needs for increased innovation capabilities, the study offers a first step toward understanding how this is currently counteracted through governance design.
Extracts of Elaeagnus multiflora Thunb. fruit fermented by lactic acid bacteria inhibit SW480 human colon adenocarcinoma via induction of cell cycle arrest and suppression of metastatic potential
Authors: Lizardo Rona Camille M. , Cho Hyun‐Dong , Lee Jin‐Hwan , Won Yeong‐Seon , Seo Kwon‐Il 
Published: July 2020

AbstractElaeagnus multiflora Thunb. (cherry silverberry, CS) is an underutilized fruit with notable phytochemical profile and biological activities. However, there are few studies on cancer inhibitory effect using fermented CS fruits. This study aimed to develop fermented CS fruits using lactic acid bacteria and investigate its anticolorectal cancer (CRC) property and phenolic composition. SW480 CRC cells were treated with aqueous extracts of CS fermented by single and coculture of Lactobacillus plantarum and L. casei. The extracts of fermented CS exhibited greater antiproliferative activity and anticlonogenicity in comparison with the unfermented extract and the control. Among the extracts of CS fruits, the ones fermented by the coculture (LPLC) showed the most potent tumor suppression property, at 25 to 50 µg/mL, by induction of cell cycle arrest at the S and G2/M phases, downregulating cyclins and its dependent kinases while increasing tumor suppressor proteins p27 and p53. LPLC also exerted its tumor suppression effect by inhibiting the chemotactic motility and invasiveness of SW480 cells, downregulating matrix metalloproteinase‐9, and PI3K/AKT/mTOR pathways and upregulating TIMP‐9, and E‐cadherin. HPLC‐PDA analysis revealed that the levels of major flavonoids in CS extracts, namely, catechin, epigallocatechin, epicatechin, epigallocatechin gallate, rutin, naringin, and quercetin, were enhanced by fermentation with L. plantarum and L. casei in coculture. Overall, this study showed that the extracts of fermented CS have augmented and multifaceted anticancer property and can be utilized in the development of functional food or ingredient for the prevention of CRC.Practical ApplicationElaeagnus multiflora, commonly known as cherry silverberry, has been proven to contain bioactive components and possesses high functionality. However, due to limited shelf‐life as a fresh commodity, development of novel product is essential. Fermentation is a beneficial process employed in the food industry to enhance the shelf stability, nutritional, sensory, and functional properties of food products. The present study has explored the possibility of adding value to an underutilized fruit, cherry silverberry, through the process of fermentation, making it as a potential source of functional food and ingredient for the prevention of colorectal cancer.
LINC00662 promotes cell viability and metastasis in esophageal squamous cell carcinoma by sponging miR‐340‐5p and upregulating HOXB2
Authors: Zhang Zhimei , Liang Xuyang , Ren Ling , Zhang Shuxian , Li Shouying , Wan Tongxun , Xu Dazhou , Lv Shengxiang 
Published: July 2020

AbstractBackgroundPrevious studies have shown that lncRNA LINC00662 plays an important role in pathogenesis of malignancies. The purpose of this study was to elucidate the regulatory mechanism of LINC00662 in esophageal squamous cell carcinoma (ESCC).MethodsIn this study, the regulatory mechanism of LINC00662 was investigated by RT‐qPCR. MTT, transwell and dual luciferase reporter assays.ResultsUpregulation of LINC00662 was found in ESCC and associated with worse clinical outcomes in ESCC patients. More importantly, knockdown of LINC00662 restrained cell proliferation, migration and invasion in ESCC. In addition, LINC00662 acts as a molecular sponge for miR‐340‐5p in ESCC, and miR‐340‐5p directly targets HOXB2. HOXB2 expression can be positively regulated by LINC00662 in ESCC. Furthermore, HOXB2 downregulation or miR‐340‐5p overexpression weakened the carcinogenesis of LINC00662 in ESCC.ConclusionsLncRNA LINC00662 promotes the progression of ESCC by upregulating HOXB2 by sponging miR‐340‐5p.
Randomised trial of bipolar resection vs holmium laser enucleation vs Greenlight laser vapo‐enucleation of the prostate for treatment of large benign prostate obstruction: 3‐years outcomes
Authors: Elshal Ahmed M. , Soltan Mohamed , El‐Tabey Nasr A. , Laymon Mahmoud , Nabeeh Adel 
Published: July 2020

ObjectiveTo compare transurethral resection in saline (TURIS), Greenlight laser vapo‐enucleation of the prostate (GL.PVEP), and holmium laser enucleation of the prostate (HoLEP), for controlling lower urinary tract symptoms secondary to large benign prostatic hyperplasia (BPH) and to assess non‐inferiority of 3‐year re‐treatment rates.Patients and MethodsEligible patients with BPH (prostate size 80–150 mL) were randomly assigned to one of the intervention groups. Non‐inferiority of re‐treatment rate was evaluated using a one‐sided test at 5% level of significance.ResultsAt the time of analysis, 60 GL.PVEP, 60 HoLEP and 62 TURIS procedures were included. Perioperative parameters were comparable between groups; however, the operative time was longer in GL.PVEP vs HoLEP and TURIS, at a mean (SD) of 92 (32) vs 73 (30) and 83 (28) min (P = 0.005); and was less effective with a mean (SD) removal of 1.2 (0.4) vs 1.7 (0.7) and 1.4 (0.6) g/min (P < 0.001), respectively. Perioperative complications and need for auxiliary procedures were similar in the three groups; however, there was a significantly higher rate of capsular perforation in TURIS group (five, 8%) compared to one (1.6%) in the GL.PVEP group and none in the HoLEP group (P= 0.01). There was a significantly longer hospital stay, catheter‐time and higher rate of blood transfusion in the TURIS group. There was significant but comparable improvements in the International Prostate Symptom Score in three groups at different follow‐up points. At 3 years, re‐treatment for recurrent bladder outlet obstruction was required more after GL.PVEP and TURIS. More re‐do surgeries for recurrent obstructing prostate adenoma was reported after GL.PVEP (four, 6.7%) and TURIS (six, 9.7%) than for HoLEP (none) (P = 0.04).ConclusionThe perioperative outcomes of GL.PVEP and HoLEP surpassed that of TURIS for the treatment of large prostates, but with a significantly prolonged operative time with GL.PVEP. The three techniques achieve good functional outcomes; however, 3‐year re‐treatment rates following TURIS and GL.PVEP were inferior to HoLEP.
Pancreatic stellate cells exhibit adaptation to oxidative stress evoked by hypoxia
Authors: Estaras Matias , Martinez‐Morcillo Salome , García Alfredo , Martinez Remigio , Estevez Mario , Perez‐Lopez Marcos , Miguez Maria P. , Fernandez‐Bermejo Miguel , Mateos Jose M. , Vara Daniel , Blanco Gerardo , Lopez Diego , Roncero Vicente , Salido Gines M. , Gonzalez Antonio 
Published: July 2020

Background informationPancreatic stellate cells play a key role in the fibrosis that develops in diseases such as pancreatic cancer. In the growing tumour, a hypoxia condition develops under which cancer cells are able to proliferate. The growth of fibrotic tissue contributes to hypoxia. In this study, the effect of hypoxia (1% O2) on pancreatic stellate cells physiology was investigated. Changes in intracellular free‐Ca2+ concentration, mitochondrial free‐Ca2+ concentration and mitochondrial membrane potential were studied by fluorescence techniques. The status of enzymes responsible for the cellular oxidative state was analyzed by quantitative reverse transcription‐polymerase chain reaction, high‐performance liquid chromatography, spectrophotometric and fluorimetric methods and by Western blotting analysis. Cell viability and proliferation were studied by crystal violet test, 5‐bromo‐2‐deoxyuridine cell proliferation test and Western blotting analysis. Finally, cell migration was studied employing the wound healing assay.ResultsHypoxia induced an increase in intracellular and mitochondrial free‐Ca2+ concentration, whereas mitochondrial membrane potential was decreased. An increase in mitochondrial reactive oxygen species production was observed. Additionally, an increase in the oxidation of proteins and lipids was detected. Moreover, cellular total antioxidant capacity was decreased. Increases in the expression of superoxide dismutase 1 and 2 were observed and superoxide dismutase activity was augmented. Hypoxia evoked a decrease in the oxidized/reduced glutathione ratio. An increase in the phosphorylation of nuclear factor erythroid 2–related factor and in expression of the antioxidant enzymes catalytic subunit of glutamate‐cysteine ligase, catalase, NAD(P)H‐quinone oxidoreductase 1 and heme oxygenase‐1 were detected. The expression of cyclin A was decreased, whereas expression of cyclin D and the content of 5‐bromo‐2‐deoxyuridine were increased. This was accompanied by an increase in cell viability. The phosphorylation state of c‐Jun NH2‐terminal kinase was increased, whereas that of p44/42 and p38 was decreased. Finally, cells subjected to hypoxia maintained migration ability.Conclusions and SignificanceHypoxia creates pro‐oxidant conditions in pancreatic stellate cells to which cells adapt and leads to increased viability and proliferation.
Randomized controlled trial of triple versus dual inhaler therapy on small airways in smoking asthmatics
Authors: Jabbal Sunny , Kuo Chris RuiWen , Lipworth Brian 
Published: July 2020

AbstractBackgroundSmoking worsens underlying asthma inflammation and also induces resistance to inhaled corticosteroids (ICS). Small airways dysfunction measured by impulse oscillometry (IOS) is associated with worse control.ObjectivesWe investigated the effects on small airways of adding long‐acting beta‐agonist (LABA) alone or with long‐acting muscarinic antagonist (LAMA) to ICS in asthmatic smokers.MethodsSixteen current smokers were enrolled: mean age 44 year, FEV1 84%, FEF25‐75 47%, R5 158%, ACQ 1.69, 20 pack year . Patients were converted to a reference ICS as HFA‐BDP during initial run‐in at median dose of 800 µg/day. Open label olodaterol 5 µg od (OLO) or olodaterol 5 µg/tiotropium 5 µg od (OLO/TIO) was added to HFA‐BDP for median duration of 3 weeks in a randomized cross over design, including run‐in and washout periods on HFA‐BDP. IOS and spirometry were measured after each treatment (BDP/OLO/TIO or BDP/OLO) and at baseline after run‐in and washout (BDP).ResultsAfter chronic dosing, IOS outcomes at trough except for R20 were all significantly improved with OLO/TIO compared to OLO. For the primary end‐point of total airway resistance (as R5), the mean difference (95%CI) at trough was 0.06 (0.015‐0.10) kPa/l/s, peripheral airways resistance (as R5‐R20) 0.03 (0.003‐0.06) kPa/l/s, peripheral lung reactance area (as AX) 0.38 (0.08‐0.68) kPa/l and resonant frequency (as RF) 2.28 (0.45‐4.12) Hz. FEF25‐75 at trough was also better with OLO/TIO vs TIO: 0.93 (0.86 ‐ 0.95) l/s while FEV1 was not different.ConclusionsICS/LABA/LAMA was superior to ICS/LABA on trough small airway outcomes in asthma patients who smoke.