bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fast Algorithms for Conducting Large-Scale GWAS of Age-at-Onset Traits Using Cox Mixed-Effects Models
Authors: He Liang , Kulminski Alexander M 
Published: March 2020

AbstractAge-at-onset traits are of paramount importance in studies of age-related diseases and behavioral genetics. Cox mixed-effects models (CMEMs) are widely used when sample dependence is taken into account. However, the application of CMEMs in genome-wide association...Age-at-onset is one of the critical traits in cohort studies of age-related diseases. Large-scale genome-wide association studies (GWAS) of age-at-onset traits can provide more insights into genetic effects on disease progression and transitions between stages. Moreover, proportional hazards (or Cox) regression models can achieve higher statistical power in a cohort study than a case-control trait using logistic regression. Although mixed-effects models are widely used in GWAS to correct for sample dependence, application of Cox mixed-effects models (CMEMs) to large-scale GWAS is so far hindered by intractable computational cost. In this work, we propose COXMEG, an efficient R package for conducting GWAS of age-at-onset traits using CMEMs. COXMEG introduces fast estimation algorithms for general sparse relatedness matrices including, but not limited to, block-diagonal pedigree-based matrices. COXMEG also introduces a fast and powerful score test for dense relatedness matrices, accounting for both population stratification and family structure. In addition, COXMEG generalizes existing algorithms to support positive semidefinite relatedness matrices, which are common in twin and family studies. Our simulation studies suggest that COXMEG, depending on the structure of the relatedness matrix, is orders of magnitude computationally more efficient than coxme and coxph with frailty for GWAS. We found that using sparse approximation of relatedness matrices yielded highly comparable results in controlling false-positive rate and retaining statistical power for an ethnically homogeneous family-based sample. By applying COXMEG to a study of Alzheimer’s disease (AD) with a Late-Onset Alzheimer’s Disease Family Study from the National Institute on Aging sample comprising 3456 non-Hispanic whites and 287 African Americans, we identified the APOE ε4 variant with strong statistical power (P = 1e−101), far more significant than that reported in a previous study using a transformed variable and a marginal Cox model. Furthermore, we identified novel SNP rs36051450 (P = 2e−9) near GRAMD1B, the minor allele of which significantly reduced the hazards of AD in both genders. These results demonstrated that COXMEG greatly facilitates the application of CMEMs in GWAS of age-at-onset traits.
Biological characteristics of the japanese scad <i>Decapterus maruadsi </i> in Thuan An estuary, Thua Thien Hue Province
Authors: Anh Tran Thi Ngoc , Huan Nguyen Xuan , Thanh Tran Trung , Nam Nguyen Thanh 
Published: March 2020

A total of 257 Decapterus maruadsi individuals of collected from Thuan An estuary in Phu Vang District, Thua Thien Hue Province were analyzed. Results showed that the fork length ranged from 90 mm to 215 mm (160.2 mm on average) and mainly in the 140–180 mm range (86.8 %). Of three age groups (0+ to 2+), the fished stock belongfrom is primarily to the 1+ age group (63.8%) and 0+ age group (28.8%). Of five stomach fullness levels (0 to 4), the second and fourth degree made up significantly proportions, being 29.6% and 31.5%, respectively. For the five fat levels (0 to 4), the fourth degree made up 86.0%. The females to males ratio was 1.00 : 1.42. von Bertalanffy’s growth model followed the equation: Lt = 203.77 × (1–e-0.3747(t+3.0272)).
Developing the Team While Travelling: Infusing Elements of High Impact Practices into a Study Abroad Course for Student-Athletes
Authors: Leupold Christopher R , Weaver Anthony G , Hall Eric H 
Published: March 2020

Undergraduate institutions today are increasingly looking to adopt high impact practices (HIP) as a means to provide optimal learning experiences for their students. Study abroad courses are a particularly popular HIP offerings for students, as they provide opportunities to not only experience new cultures around the world but also to gain insights into their own cultural identities. However, because of the many demands placed on Division I collegiate student-athletes, they unfortunately are often not able to engage in such a global experience. This case study describes a credit-bearing, short-term study abroad course that not only taught Division I volleyball student-athletes about theories of culture and how to analyze culture at the individual, team, and national levels; but infused a variety of experiential activities and other elements characteristic of effective HIPs. As a means to make the course more personally relevant and meaningful to these students, special attention was given to present topics in a context specific to a collegiate athletic team. These student-athletes were introduced to a host of relevant validated models and theories of culture, and engaged in a number of individual assessments to gain insights into their cultural identities and their influences, as well as in formal assessments of as their team’s dynamics and overall effectiveness. In addition, the course included team-based activities and workshops that addressed the team’s weakest areas related to performance. identified areas in need of improvement. All of these activities were aligned with a 10-day travel experience to Italy. Overall, this case study is an example of how an innovative course can be created to not only provide a study abroad opportunity for student-athletes, but also be tailored to address individual players’ and team needs and create a positive and lasing experience for all involved.
African American Scholars and the Margins of DH
Authors: Rambsy II Howard 
Published: March 2020

Let's Cut to the Chase: African American Scholars Occupy the Margins of this Expansive Realm Known as Digital Humanities. Do well-intentioned people want more diversity in DH? Sure, they do. Do black folks participate in DH? Of course, we do. But we've witnessed far too many DH panels with no African American participants or with only one. We've paid close attention to where the major funding for DH goes. Or, we've carefully taken note of who the authors of DH-related articles, books, and bibliographies are. We've studied these things closely enough to realize who resides in prime DH real estate and who doesn't. We could speak defiantly about our marginal status the way Toni Morrison once did when she quipped, “I'm gonna stay out here on the margin, and let the center look for me” (87). Yaasss!At the same time, though, it's worth thinking about some of the reasons why African American scholars dwell on the margins of the DH field. The processes by which we pursue graduate study and become participants in the field of African American literary studies account for why we are slow or reluctant to embrace DH. There's also the matter of segregation—our persistent exclusion from projects and opportunities that are ostensibly open to all but invariably involve primarily white scholars. Immersion in the field of African American literary studies and conversations with senior and emergent scholars reveal some of the reasons why we stand so far from the center of the DH community.
Influence of Employer Brand Image on Employee Identity
Authors: Shaker Fahim , Ahmed A.S. Nooruddin 
Published: March 2020

This study aims to provide a framework of understanding the relation between employee identity construction and organization’s employer brand image. Theoretically, employer brand image and identity construction are two different topics in different disciplines and have evolved separately from each others. The current paper tries to draw a relation between these two topics by addressing research work from employer branding, employee identity construction, literature on the dirty work and so forth. Drawing this relation is significantly important as in the future it may serve the framework of understanding about certain employee’s positive or negative identity construction influenced by organization’s positive or negative employer brand image. The arguments provided here are typically based on various scholars’ findings relying on classic and contemporary text within organization theory, sociology and marketing. The paper suggests few empirical investigations as future scope of research to provide a concrete understanding of the relation between employee identity negotiation and organization’s employer brand image. JEL Classification Code: M 10; M 12; M 14
Does laryngopharyngeal reflux disease impair nasal mucociliary transport? A case control prospective study
Authors: Vasu Pooja K. , Gopalankutty Nayana V. , Somayaji Gangadhara 
Published: March 2020

<p class="abstract"><strong>Background:</strong> Laryngopharyngeal reflux disease (LPRD) is the retrograde reflux of gastro duodenal contents above the level of upper oesophageal sphincter into larynx and pharynx. LPRD can lead to upper respiratory pathology by direct contact of nasal and nasopharyngeal mucosa with the regurgitated gastric acid. Refluxate can damage the cilia, thereby prolonging the mucociliary clearance time (MCT) and consequently affecting the innate defence mechanism of upper airway. Our objective was to analyse the relationship between MCT and LPRD in patients without any nasal pathology.</p><p class="abstract"><strong>Methods:</strong> This study was a prospective case control study, with 45 patients each in the study and reference group. Study group included patients with symptoms of LPRD who fulfilled the reflux symptom index (RSI) score of more than 13 points. The reference group included subjects without LPRD, with RSI less than 13. In both groups, conditions causing impaired MCT like allergic rhinitis, sinusitis, rhinitis and history of smoking were excluded. Chronic sinusitis cases were excluded in both groups using sino-nasal outcome test -22 scoring system. Nasal MCT was measured in all these participants using the Saccharin test. Duration more than 20 minutes was taken as prolonged mucociliary clearance time. </p><p class="abstract"><strong>Results:</strong> MCT was prolonged in 62% of subjects (28 out of 45) in the study group whereas, in the reference population MCT was normal.</p><p class="abstract"><strong>Conclusions:</strong> LPRD is a contributing factor for impaired nasal mucociliary transport.</p>
Hospital based study on the effect of flood on change in profile of otomycosis in ethnic Kashmiri population
Authors: Sumbria Deepshikha , Yousuf Aamir , Ahmad Rauf 
Published: March 2020

<p class="abstract"><strong>Background:</strong> Kashmir valley witnessed devastating floods in the month of September 2014. The target of the study was to assess the changes in clinical profile of otomycosis and fungi responsible for the disease, in-vitro sensitivity of different fungi to various commercially available antimycotic solutions and clinical efficacy of various topical antimycotic solutions in otomycosis in pre and post flood period.</p><p class="abstract"><strong>Methods:</strong> This study was conducted in the Department of ENT, GMC, Srinagar from February 2014 to July 2015. 152 clinically suspected otomycosis patients were subjected to mycological tests to identify the organism. Clotrimazole, terbinafine, lulliconazole, sertaconazole and combination of 1% clotrimazole, chloramphenicol, beclomethasone was given randomly in equal number of these patients and were followed for 4 weeks. Results of different antifungals were evaluated clinically. </p><p class="abstract"><strong>Results:</strong> The trend varies in pre and post flood period. <em>Candida albicans</em> was the most common organism isolated in pre-flood period whereas <em>Aspergillus flavus</em> was the most common organism isolated in post flood period. In the pre flood period <em>Candida</em> and <em>Aspergillus</em> species had equal rate of isolation. However, in post flood period <em>Aspergillus</em> was most common species isolated. Effect of lulliconazole and terbinafine was same in pre and post flood time but serticonazole and fluconazole showed slight variation in effectiveness in post flood period. Clotrimazole and combination of 1% clotrimazole, chloramphenicol and beclomethasone were least effective post flood.</p><p class="abstract"><strong>Conclusions:</strong> Flood had its impact on profile of otomycosis. <em>A. flavus</em> became more common species in post flood period. It was observed that flood had some impact on drug treatment too but further studies and tests are needed to confirm the effectiveness of drugs on treatment of otomycosis.</p>
Clinical profile and causality of cutaneous adverse drug reactions among patients attending tertiary care teaching hospital in South India
Authors: Mavoori Archana , Bala Sudha , Pamar Sneha , Podila Karunasree , Sriram Deepthi 
Published: March 2020

<p class="abstract"><strong>Background:</strong> Any undesirable change in the structure or function of the skin and its appendages related to drug eruption regardless of the aetiology is called the cutaneous adverse drug reaction (CADR). Manifestations are varied with diverse morphological pattern ranging from trivial urticarial to severe form of vasculitis which are fatal. Identifying the culprit drug in this new era with advanced development of multi drugs is a challenging task and can help in prevention of further complications and provide safer drugs. Objective of the study was to assess the clinical profile and causality of CADR among patients in a tertiary care hospital of Hyderabad.</p><p class="abstract"><strong>Methods:</strong> An observational hospital-based study was undertaken over a 6 months period among patients attending dermatology OPD of medical college and hospital located at Hyderabad. Patients presenting with suspected drug-related cutaneous lesions were included where the drug responsible was ascertained. Drug history was recorded in a format specified in Indian National Pharmacovigilance Programme and causality assessment carried out as per world health organization-uppsala monitoring centre criteria.<strong></strong></p><p class="abstract"><strong>Results:</strong> The study population consisted of females (52.4%) and males (47.6%). Majority of them were in the age group of 51-60 years. Most common pattern of CADR noted were urticaria (19.05%) followed by erythema multiforme (17.46%) and morbilliform rash (17.46%). The common drugs categorised for these reactions comprised of antibiotics (39%), nonsteroidal anti-inflammatory drugs (26%) followed by anti tubercular treatment (18%).</p><p class="abstract"><strong>Conclusions:</strong> CADR contribute to significant morbidity among industrial workers and role of pharmacovigilance should be further emphasized to reduce such reactions. </p>
Role of intralesional vitamin D3 in cutaneous warts: an interventional study
Authors: Kumar Sweta S. , Awasthi Sankalp , Kumar Adesh , Jain Prateek 
Published: March 2020

<p class="abstract"><strong>Background:</strong> Cutaneous warts are treated primarily with destructive methods such as cryotherapy or electrocautery. These modalities of treatment may be associated with recurrence and scarring in multiple warts. This study aims to evaluate the efficacy and safety of intralesional vitamin D3 in warts.</p><p class="abstract"><strong>Methods:</strong> 88 patients with recalcitrant warts of varying sizes and duration were included in the study. About 0.2 to 0.5 ml vitamin D3 solution (600,000 IU, 15 mg/ml) was injected to the base of the wart. A maximum of 5 warts were injected per session at 3-week intervals until resolution or for a maximum of 4 treatments. Patients were followed up for 6 months after the last injection to detect any recurrence.<strong></strong></p><p class="abstract"><strong>Results:</strong> 88 patients completed the study. Complete response was seen in 63 out of 88 (71.5%), partial response in 24 out of 88 (27.2%), and no response seen in one patient. The average number of injections required to achieve a complete resolution was 3.66. Complete resolution of distant warts was noticed in all the patients.</p><p class="abstract"><strong>Conclusions:</strong> Intralesional vitamin D3 is a safe, effective, and an inexpensive treatment option for recalcitrant warts.</p><p> </p>
Lex mercatoria and private international arbitration = Lex mercatoria y arbitraje privado internacional
Authors: Calvo Caravaca Alfonso-Luis , Carrascosa González Javier 
Published: March 2020

Abstract: The “New Lex Mercatoria” is not a “legal system” or a defined set of rules, but a “method”. In this sense, the New Lex Mercatoria consists of giving authorization to the courts and/or arbitrators to assess different legal materials regulating international trade; following that, they will extract the “most appropriate rules” to solve the litigation. It is, therefore, a method to achieve adequate decisions in international trade (Method of Decision-Making). Thus, the arbitrator is prevented from applying a single national Law, which is exactly what the parties intended to avoid at all costs and the reason why they chose the New Lex Mercatoria. In other words, it can be affirmed that the methodological approach to the New Lex Mercatoria is the most operative, useful and complete, as well as the one that enables us to develop a metacriticism of the New Lex Mercatoria as a source of Law in international trade.Keywords: Arbitration, efficiency principle, general principles of Law recognized by civilized Nations, general principles of private international law, Globalization, international contracts, international trade, delocalization, mandatory rules (in international trade), New Lex Mercatoria, “Norsolor syndrome”, Private International Law, Public Policy, sources of Law, Uniform Law.Resumen: La Nueva Lex Mercatoria es un “método” y no un “ordenamiento jurídico” ni un conjunto definido de reglas. En esta acepción, la Nueva Lex Mercatoria consiste en una habilitación ofrecida a los tribunales y/o a los árbitros para que éstos valoren distintos materiales jurídicos reguladores del comercio internacional y, tras ello, extraigan las “normas más adecuadas” para solventar el litigio. Es, por tanto, un método para alcanzar decisiones adecuadas en el comercio internacional (Method of DecisionMaking). De ese modo, se evita que el árbitro acabe por aplicar una concreta Ley estatal lo que constituye, significativamente, eso mismo que la elección de la Nueva Lex Mercatoria por las partes quiere evitar a toda costa. En otras palabras, puede afirmarse que la acepción metodológica de la Nueva Lex Mercatoria es la más operativa, la más útil, la más completa y la que permite desarrollar, precisamente, una metacrítica de la Nueva Lex Mercatoria como fuente del Derecho de los negocios internacionales. Palabras clave: Arbitraje, comercio internacional, contratos internacionales, Derecho Internacional Privado, Derecho Uniforme, deslocalización, fuentes del Derecho, Globalización, normas imperativas (en el comercio internacional), Nueva Ley Mercatoria, orden público, principios generales de Derecho Internacional Privado, principios generales del Derecho reconocidos por las naciones civilizadas, “síndrome Norsolor”.
EL nuevo Reglamento (UE) 2019/1111: análisis de las mejoras en las relaciones con el Convenio de la Haya de 19 de octubre de 1996 sobre responsabilidad parental = The new Regulation (EU) 2019/1111: analysis of the improvements in the relations with the Hague Convention of 19 october 1996 about parental responsibility
Authors: Campuzano Díaz Beatriz 
Published: March 2020

Resumen: En materia de responsabilidad parental, el Reglamento 2201/2003 tiene que aplicarse conjuntamente con el Convenio de La Haya de 1996, en el que la Unión Europea ha decidido participar. La coordinación de estos dos instrumentos internacionales ha resultado difícil, en relación particularmente con las normas de competencia judicial internacional. Uno de los objetivos del nuevo Reglamento 2019/1111 ha sido solventar este problema, con la adición de un nuevo párrafo al precepto dedicado a regular las relaciones con el Convenio de La Haya del 96 (art. 61 del Reglamento 2201/2003, ahora art. 97 del Reglamento 2019/1111), que es objeto de análisis en el presente estudio.Palabras clave: Reglamento 2019/1111, Convenio Haya 1996, Coordinación, normas de competencia judicial internacional.Abstract: In parental responsibility issues, Regulation 2201/2203 has to be applied in conjunction with the 1996 Hague Convention, in which the European Unión has decided to participate. The coordination of these two bodies of international rules has shown to be difficult, particularly in relation with the jurisdiction rules. One of the objectives of new Regulation 2019/1111 is to solve this problem, with the addition of a new paragraph to the article dedicated to regulate the relations with the 1996 Hague Convention (art. 61 of Regulation 2201/2003, now art. 97 of Regulation 2019/1111), which is analysed in this study.Keywords: Regulation 2019/1111; 1996 Hague Convention; Coordination; Jurisdiction rules.
La protección del crédito transfronterizo mediante la orden europea de retención de cuentas. En torno a la STJUE C-555/18 de 7 de noviembre de 2019 = The protection of the cross-border credit by the European Account Preservation Order. Regarding the ECJ Judgment C-555/18 Of 7 November of 2019
Authors: Antón Juárez Isabel 
Published: March 2020

Resumen: La orden europea de retención de cuentas es una medida muy útil que intenta facilitar el cobro de las deudas transfronterizas. La sentencia del TJUE de 7 de noviembre de 2019 es la primera sentencia sobre el Reglamento 655/2014. Reglamento europeo que instaura esta medida cautelar europea en todos los Estados miembros de la UE a excepción de Dinamarca. Esta sentencia muestra que la aplicación de la orden europea de retención de cuentas puede no resultar fácil de aplicar a los tribunales nacionales. Una de las razones es que su aplicación requiere de una combinación armónica entre lo dispuesto en el Reglamento 655/2014 y los derechos procesales nacionales. El TJUE, con esta sentencia que analizamos, intenta allanar el camino hacia la búsqueda de esa aplicación armónica y sobre todo homogénea del R. 655/2014 por los tribunales nacionales de los Estados miembros.Palabras clave: medida cautelar, orden europea de retención de cuentas, deuda transfronteriza.Abstract: The European Account Preservation Order is a very useful measure that attempts to facilite the collection of cross-border debts. The ECJ judgment of 7 of November of 2019 is the first about the Regulation 655/2014. This Regulation establishes the European precautionary measure in all EU member states with the exception of Denmark. This ruling shows that the application of the European Account Preservation Order may not be easy to apply to national courts. One of the reasons is that its application requires a harmonious combination between the provisions of Regulation 655/2014 and national procedural orders. The ECJ with this judgment that we analyze tries to pave the way towards the search for that harmonious and especially homogeneous application of R. 655/2014 by the national courts of the member states. Keywords: provisional measure, European Account Preservation Order, cross-border debt.