bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Secukinumab for Plaque Psoriasis in a Patient on Hemodialysis
Authors: Ikuma Daiuske , Oguro Masahiko , Hoshino Junichi , Mizuno Hiroki , Sekine Akinari , Kawada Masahiro , Hiramatsu Rikako , Sumida Keiichi , Hasegawa Eiko , Hayami Noriko , Yamanouchi Masayuki , Suwabe Tatsuya , Sawa Naoki , Takaichi Kenmei , Ubara Yoshifumi 
Published: October 2019

Abstract
Secukinumab is effective to treat plaque psoriasis. However, the safety and efficiency of secukinumab have not been clarified in patients on hemodialysis. We report a 60-year-old Japanese woman. Plaque psoriasis was diagnosed at the age of 25 years and hemodialysis was started at the age of 39 years. Her skin lesions persisted despite use of topical agents such as maxacalcitol and betamethasone. Accordingly, administration of secukinumab was started at a dose of 150 mg. The psoriasis area and severity index (PASI) score decreased from 49.8 to 14.8 after 2 weeks and to 0 after 6 weeks, with remission being maintained after 28 months. No adverse reactions were seen. This case indicates that secukinumab may be effective for severe psoriasis in patients on hemodialysis for end-stage renal disease.
The complete chloroplast genome of Saxifraga sinomontana (Saxifragaceae) and comparative analysis with other Saxifragaceae species
Authors: Li Yan , Jia Liukun , Wang Zhihua , Xing Rui , Chi Xiaofeng , Chen Shilong , Gao Qingbo 
Published: October 2019

AbstractSaxifraga sinomontana J.-T. Pan & Gornall belongs to Saxifraga sect. Ciliatae subsect. Hirculoideae, a lineage containing ca. 110 species whose phylogenetic relationships are largely unresolved due to recent rapid radiations. Analyses of complete chloroplast genomes have the potential to significantly improve the resolution of phylogenetic relationships in this young plant lineage. The complete chloroplast genome of S. sinomontana was de novo sequenced, assembled and then compared with that of other six Saxifragaceae species. The S. sinomontana chloroplast genome is 147,240 bp in length with a typical quadripartite structure, including a large single-copy region of 79,310 bp and a small single-copy region of 16,874 bp separated by a pair of inverted repeats (IRs) of 25,528 bp each. The chloroplast genome contains 113 unique genes, including 79 protein-coding genes, four rRNAs and 30 tRNAs, with 18 duplicates in the IRs. The gene content and organization are similar to other Saxifragaceae chloroplast genomes. Sixty-one simple sequence repeats were identified in the S. sinomontana chloroplast genome, mostly represented by mononucleotide repeats of polyadenine or polythymine. Comparative analysis revealed 12 highly divergent regions in the intergenic spacers, as well as coding genes of matK, ndhK, accD, cemA, rpoA, rps19, ndhF, ccsA, ndhD and ycf1. Phylogenetic reconstruction of seven Saxifragaceae species based on 66 protein-coding genes received high bootstrap support values for nearly all identified nodes, suggesting a promising opportunity to resolve infrasectional relationships of the most species-rich section Ciliatae of Saxifraga.
Construction robotics for designed granular materials: in situ construction with designed granular materials at full architectural scale using a cable-driven parallel robot
Authors: Dierichs Karola , Kyjánek Ondřej , Loučka Martin , Menges Achim 
Published: October 2019

Abstract
The article presents a cable-driven parallel robot for the in situ construction with designed granular materials at full architectural scale. Granular materials are defined as high numbers of particles larger than a micrometer, between which only short-range repulsive forces are acting. Therefore, they can have the properties of both a solid and a liquid. These materials are, thus, highly pertinent as construction materials, since they are fully recyclable and reconfigurable. Going even beyond these basic properties, a designed granular material allows to tune its overall characteristics through the design of the individual particle. Granular materials can only be deployed in situ and at full scale. Suitable robotic construction systems need to be developed. Cable-driven parallel robots are defined as robotic systems, in which an “end effector” is operated by a set of cables, which are driven by computer numerically controlled motors. The cables are running through elevated pulleys. A cable-driven parallel robot, thus, allows for a “working space”, which covers an entire building site. It is comparatively lightweight and, thus, transportable between different construction sites, it is rapidly deployable, since the entire set-up takes one day only, and it is adaptable, since the pulleys can be installed in various geometric configurations. The results of this investigation show that cable-driven parallel robots are suitable as construction systems for the full-scale in situ construction of spatial enclosures with designed granular materials. This opens up a new field of research into the potentials of these full-scale, lightweight, rapidly deployable and adaptable robotic construction systems.
Assessment of Lift Passenger Comfort by the Hilbert–Huang Transform
Authors: Szydło Kamil , Wolszczak Piotr , Longwic Rafał , Litak Grzegorz , Dziubiński Mieczysław , Drozd Artur 
Published: October 2019

Abstract

Purpose
The comfort of lift passengers has a significant effect on their general health condition as well as stress levels during travel. This study reports the results of vibration measurements taken during travel in a passenger lift.

Methods
Vibration signals were analyzed by the empirical mode decomposition method and the Hilbert transform.

Results
Selected modes from the Hilbert spectral analysis were compared with the resonance frequencies of human body organs (range 20–90 Hz) as well as with the resonance frequencies of lift components.

Conclusion
The use of Hilbert spectral analysis enables the isolation of individual signal components and the determination of the dominant frequency in the signal. This, in turn, allows for the isolation of raw vibration frequencies from the signal that are particularly significant for passenger comfort assessment (resonance frequencies of human body organs) and analysis of their occurrence.
Influence of the shape and mass of a small robot when thrown to a dummy human head
Authors: Alhaddad Ahmad Yaser , Cabibihan John-John , Hayek Ahmad , Bonarini Andrea 
Published: October 2019

Abstract
Social robots have shown some efficacy in assisting children with autism and are now being considered as assistive tools for therapy. The physical proximity of a small companion social robot could become a source of harm to children with autism during aggressive physical interactions. A child exhibiting challenging behaviors could throw a small robot that could harm another child’s head upon impact. In this paper, we investigate the effects of the mass and shape of objects thrown on impact at different velocities on the linear acceleration of a developed dummy head. This dummy head could be the head of another child or a caregiver in the room. A total of 27 main experiments were conducted based on Taguchi’s orthogonal array design. The data were then analyzed using ANOVA and then optimized based on the signal-to-noise ratio. Our results revealed that the two design factors considered (i.e. mass and shape) and the noise factor (i.e. impact velocities) affected the response. Finally, confirmation runs at the optimal identified shape and mass (i.e. mass of 0.3 kg and shape of either cube or wedge) showed an overall reduction in the resultant peak linear acceleration of the dummy head as compared to the other conditions. These results have implications on the design and manufacturing of small social robots whereby minimizing the mass of the robots can aid in mitigating the potential harm to the head due to impacts.
An innovative method of extraction of coffee oil using an advanced microwave system: in comparison with conventional Soxhlet extraction method
Authors: Hibbert Sam , Welham Kevin , Zein Sharif H. 
Published: October 2019

Abstract
The production of energy and chemicals from waste biomass is an attractive alternative by comparison with first-generation biofuels and fossil feedstocks. This paper investigates oil extraction from spent coffee grounds (SCG) by means of an advanced microwave process and compares this with a conventional Soxhlet extraction (SE) method. Microwave-assisted oil extraction (MAE) from SCG was performed over different durations, varying solvent volumes and extraction temperatures. It was found that each of these parameters had an effect on the process, with the largest yield being over 11.54 wt%, oil extracted in 10 min using 160 mL of hexane at 95 °C. In 10 min, MAE was successful in extracting more oil than SE. MAE achieved a 24-fold decrease in duration for the extraction compared with SE and used less solvent per gram of oil produced. It is proposed that a certain moisture content in the SCG would be beneficial to the extraction process and might it also play a role in the heating process. The extracted oil can be converted into biodiesel and biochemicals leaving the remaining solids suitable for processing into bioethanol, fertiliser, adsorptive material and fuel pellets.

Graphic Abstract
Evaluation of the AMSR2 L2 soil moisture product of JAXA on the Mongolian Plateau over seven years (2012–2018)
Authors: Kaihotsu Ichirow , Asanuma Jun , Aida Kentaro , Oyunbaatar Dambaravjaa 
Published: October 2019

Abstract
This study evaluated the Advanced Microwave Scanning Radiometer 2 (AMSR2) L2 soil moisture product (ver. 3) using in situ hydrological observational data, acquired over 7 years (2012–2018), from a 50 × 50 km flat area of the Mongolian Plateau covered with bare soil, pasture and shrubs. Although AMSR2 slightly underestimated soil moisture content at 3-cm depth, satisfactory timing was observed in both the response patterns and the in situ soil moisture data, and the differences between these factors were not large. In terms of the relationship between AMSR2 soil moisture from descending orbits and in situ measured soil moisture at 3-cm depth, the values of the RMSE (m3/m3) and the bias (m3/m3) varied from 0.028 to 0.063 and from 0.011 to − 0.001 m3/m3, respectively. The values of the RMSE and bias depended on rainfall condition. The mean value of the RMSE for the 7-year period was 0.042 m3/m3, i.e., lower than the target accuracy 0.050 m3/m3. The validation results for descending orbits were found slightly better than for ascending orbits. Comparison of the Soil Moisture and Ocean Salinity (SMOS) soil moisture product with the AMSR2 L2 soil moisture product showed that AMSR2 could observe surface soil moisture with nearly same accuracy and stability. However, the bias of the AMSR2 soil moisture measurement was slightly negative and poorer than that of SMOS with deeper soil moisture measurement. It means that AMSR2 cannot effectively measure soil moisture at 3-cm depth. In situ soil temperature at 3-cm depth and surface vegetation (normalized difference vegetation index) did not influence the underestimation of AMSR2 soil moisture measurements. These results suggest that a possible cause of the underestimation of AMSR2 soil moisture measurements is the difference between the depth of the AMSR2 observations and in situ soil moisture measurements. Overall, this study proved the AMSR2 L2 soil moisture product has been useful for monitoring daily surface soil moisture over large grassland areas and it clearly demonstrated the high-performance capability of AMSR2 since 2012.
Marine accident learning with fuzzy cognitive maps (MALFCMs) and Bayesian networks
Authors: de Maya Beatriz Navas , Babaleye Ahmed O. , Kurt Rafet E. 
Published: October 2019

Abstract
Addressing safety is considered a priority starting from the design stage of any vessel until end-of-life. However, despite all safety measures developed, accidents are still occurring. This is a consequence of the complex nature of shipping accidents where too many factors are involved including human factors. Therefore, there is a need for a practical method, which can identify the importance weightings for each contributing factor involved in accidents. As a result, by identifying the importance weightings for each factor, risk assessments can be informed, and risk control options can be developed and implemented more effectively. To this end, Marine Accident Learning with Fuzzy Cognitive Maps (MALFCM) approach incorporated with Bayesian networks (BNs) is suggested and applied in this study. The MALFCM approach is based on the concept and principles of fuzzy cognitive maps (FCMs) to represent the interrelations amongst accident contributor factors. Thus, MALFCM allows identifying the importance weightings for each factor involved in an accident, which can serve as prior failure probabilities within BNs. Hence, in this study, a specific accident will be investigated with the proposed MALFCM approach.
Enhanced Iron Flux to Antarctic Sea Ice via Dust Deposition From Ice‐Free Coastal Areas
Authors: Duprat L. , Kanna N. , Janssens J. , Roukaerts A. , Deman F. , Townsend A. T. , Meiners K. M. , van der Merwe P. , Lannuzel D. 
Published: October 2019

AbstractAntarctic sea ice is an important temporal reservoir of iron which can boost primary production in the marginal ice zone during the seasonal melt. While studies have reported that Antarctic fast ice bears high concentrations of iron due to the proximity to coastal sources, less clear are the biogeochemical changes this iron pool undergoes during late spring. Here we describe a 3‐week time series of physical and biogeochemical data, including iron, from first‐year coastal fast ice sampled near Davis Station (Prydz Bay, East Antarctica) during late austral spring 2015. Our study shows that dissolved and particulate iron concentrations in sea ice were up to two orders of magnitude higher than in under‐ice seawater. Furthermore, our results indicate a significant contribution of lithogenic iron from the Vestfold Hills (as deduced from the comparison with crustal element ratios) to the particulate iron pool in fast ice after a blizzard event halfway through the time series. Windblown dust represented approximately 75% of the particulate iron found in the ice and is a potential candidate for keeping concentrations of soluble iron stable during our observations. These results suggest that iron entrapped during ice formation, likely from sediments, as well as local input of coastal dust, supports primary productivity in Davis fast ice. As ice‐free land areas are likely to expand over the course of the century, this work highlights the need to quantify iron inputs from continental Antarctic dust and its bioavailability for ice algae and phytoplankton.
Autologous micrograft accelerates endogenous wound healing response through ERK-induced cell migration
Authors: Balli Martina , Vitali Francesca , Janiszewski Adrian , Caluwé Ellen , Cortés-Calabuig Alvaro , Carpentier Sebastien , Duelen Robin , Ronzoni Flavio , Marcelis Lukas , Bosisio Francesca Maria , Bellazzi Riccardo , Luttun Aernout , De Angelis Maria G. Cusella , Ceccarelli Gabriele , Lluis Frederic , Sampaolesi Maurilio 
Published: October 2019

AbstractDefective cell migration causes delayed wound healing (WH) and chronic skin lesions. Autologous micrograft (AMG) therapies have recently emerged as a new effective and affordable treatment able to improve wound healing capacity. However, the precise molecular mechanism through which AMG exhibits its beneficial effects remains unrevealed. Herein we show that AMG improves skin re-epithelialization by accelerating the migration of fibroblasts and keratinocytes. More specifically, AMG-treated wounds showed improvement of indispensable events associated with successful wound healing such as granulation tissue formation, organized collagen content, and newly formed blood vessels. We demonstrate that AMG is enriched with a pool of WH-associated growth factors that may provide the starting signal for a faster endogenous wound healing response. This work links the increased cell migration rate to the activation of the extracellular signal-regulated kinase (ERK) signaling pathway, which is followed by an increase in matrix metalloproteinase expression and their extracellular enzymatic activity. Overall we reveal the AMG-mediated wound healing transcriptional signature and shed light on the AMG molecular mechanism supporting its potential to trigger a highly improved wound healing process. In this way, we present a framework for future improvements in AMG therapy for skin tissue regeneration applications.
Leishmania donovani parasite requires Atg8 protein for infectivity and survival under stress
Authors: Giri Sagnik , Shaha Chandrima 
Published: October 2019

AbstractThe importance of autophagy in parasites with a digenetic life cycle like Leishmania spp. is significant. The parasite survives as promastigotes in the insect gut and as immotile amastigotes in mammals. This study demonstrates increased autophagy in Leishmania parasite during progression of in vitro life cycle and upon exposure to stress stimuli like starvation, oxidative stress, and drugs. Autophagy inhibition during stress exposure increased cell death, indicating the importance of autophagy in cellular defense against adverse conditions. Atg8 protein, a homolog of mammalian autophagy protein LC3 is expressed in Leishmania parasite but its function remains unknown. Overexpression of Atg8 (Atg8-OE) rendered the parasites resistant to stress and capable of infecting macrophages in substantial numbers; however, disruption of the Atg8 gene (ΔAtg8) resulting in suppression of Atg8 protein expression, increased susceptibility to stress and reduced the capability to cause infection. A critical event in the Leishmania parasite lifecycle is the differentiation of promastigote forms to the disease causing amastigote forms. The failure of ΔAtg8 parasites lacking Atg8 protein to differentiate into amastigotes, unlike the Atg8-OE and vector-transfected parasites, clearly indicated Atg8 involvement in a crucial event. The inability of ΔAtg8 parasites to infect macrophages in vitro was verified in an in vivo mouse model of leishmaniases where infection could not be induced by the ΔAtg8 parasites. Autophagy is known to be involved in the remodeling of damaged organelles. The accumulation of Atg8 around damaged mitochondria suggested increase of autophagy in the vicinity of the organelle. This buildup was prevented when mitochondria generated reactive oxygen species that were quenched, suggesting them as possible signaling molecules for sensing mitochondrial instability. In summary, our study provides new evidences for a crucial role of Atg8 protein in sustaining Leishmania parasite survival during life cycle and stress exposure, differentiation to amastigotes, and their infective abilities.
Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs
Authors: Grall Emmanuelle , Gourain Victor , Naïr Asmaa , Martin Elisabeth , Birling Marie-Christine , Freund Jean-Noël , Duluc Isabelle 
Published: October 2019

AbstractHead dysgenesis is a major cause of fetal demise and craniofacial malformation. Although mutations in genes of the head ontogenetic program have been reported, many cases remain unexplained. Head dysgenesis has also been related to trisomy or amplification of the chromosomal region overlapping the CDX2 homeobox gene, a master element of the trunk ontogenetic program. Hence, we investigated the repercussion on head morphogenesis of the imbalance between the head and trunk ontogenetic programs, by means of ectopic rostral expression of CDX2 at gastrulation. This caused severe malformations affecting the forebrain and optic structures, and also the frontonasal process associated with defects in neural crest cells colonization. These malformations are the result of the downregulation of genes of the head program together with the abnormal induction of trunk program genes. Together, these data indicate that the imbalance between the anterior and posterior ontogenetic programs in embryos is a new possible cause of head dysgenesis during human development, linked to defects in setting up anterior neuroectodermal structures.
Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis
Authors: Godet Inês , Shin Yu Jung , Ju Julia A. , Ye I Chae , Wang Guannan , Gilkes Daniele M. 
Published: October 2019

AbstractHypoxia is known to be detrimental in cancer and contributes to its development. In this work, we present an approach to fate-map hypoxic cells in vivo in order to determine their cellular response to physiological O2 gradients as well as to quantify their contribution to metastatic spread. We demonstrate the ability of the system to fate-map hypoxic cells in 2D, and in 3D spheroids and organoids. We identify distinct gene expression patterns in cells that experienced intratumoral hypoxia in vivo compared to cells exposed to hypoxia in vitro. The intratumoral hypoxia gene-signature is a better prognostic indicator for distant metastasis-free survival. Post-hypoxic tumor cells have an ROS-resistant phenotype that provides a survival advantage in the bloodstream and promotes their ability to establish overt metastasis. Post-hypoxic cells retain an increase in the expression of a subset of hypoxia-inducible genes at the metastatic site, suggesting the possibility of a ‘hypoxic memory.’
Climate-induced phenology shifts linked to range expansions in species with multiple reproductive cycles per year
Authors: Macgregor Callum J. , Thomas Chris D. , Roy David B. , Beaumont Mark A. , Bell James R. , Brereton Tom , Bridle Jon R. , Dytham Calvin , Fox Richard , Gotthard Karl , Hoffmann Ary A. , Martin Geoff , Middlebrook Ian , Nylin Sӧren , Platts Philip J. , Rasteiro Rita , Saccheri Ilik J. , Villoutreix Romain , Wheat Christopher W. , Hill Jane K. 
Published: October 2019

AbstractAdvances in phenology (the annual timing of species’ life-cycles) in response to climate change are generally viewed as bioindicators of climate change, but have not been considered as predictors of range expansions. Here, we show that phenology advances combine with the number of reproductive cycles per year (voltinism) to shape abundance and distribution trends in 130 species of British Lepidoptera, in response to ~0.5 °C spring-temperature warming between 1995 and 2014. Early adult emergence in warm years resulted in increased within- and between-year population growth for species with multiple reproductive cycles per year (n = 39 multivoltine species). By contrast, early emergence had neutral or negative consequences for species with a single annual reproductive cycle (n = 91 univoltine species), depending on habitat specialisation. We conclude that phenology advances facilitate polewards range expansions in species exhibiting plasticity for both phenology and voltinism, but may inhibit expansion by less flexible species.