bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel spectrophotometric method development and validation of Tenagliptin in its Tablet dosages form
Authors: Patra Poulami , Ghosh Somsubhra , Roy Tathagata , Ravi kumar B. V. V. 
Published: October 2019

The aim of present work was to develop a new, economical & simple analytical method of Teneligliptin & its validation as per International Conference on Harmonization (ICH) guideline, which is a new antidiabetic drug that is used to treat Non-Insulin Dependent Diabetis Melitus (NIDDM) patients. A sensitive and specific Ultra Violet (UV) Visible method was developed & the analysis was carried out by using Shimazdu 1800 Spectrophotometer, 0.1(N) NaOH was used as a solvent. The UV- Visible Spectrophotometric estimation was carried out at a λ max of 242 nm using 1cm thick quartz cell. Validation of the newly developed method was performed as per International Conference on Harmonization (ICH) Q2R1 guideline in the following parameters: Calibration curve, Accuracy, Precision etc. Newly developed method obeys Beer’s-Lambert’s law in the concentration range of 5 - 25 μg / ml, whereas correlation coefficient value is less than 1. The percent amount of drug estimated by this developed method was 100.91 %, which is very close to 100 %. The validation parameters like Accuracy, Precision, Linearity, Range, Limit of detection (LOD) & Limit of Quantification (LOQ) were studied for the developed method and was found to be within the limits.
Keywords: Teneligliptin, Validation, Method, Spectroscopy etc.
Formulation and Characterization of Aceclofenac Mouth Dissolving Tablet by QbD
Authors: Dev Asish , Yadav Shravan Kumar , Kar S.K. , Mohanty Smitapadma , Shelke Om 
Published: October 2019

The purpose of this study was to develop fast dissolving tablets of Aceclofenac using different concentration of super disintegrants. Fast dissolving tablets of Aceclofenac were prepared by dry granulation technique using croscarmellose sodium together with avicel ph as superdisintegrants. The porous granules were then compressed in to tablets by direct compression technique. These tablets were evaluated for drug content, weight variation, friability, hardness, wetting time and dispersion time. All the formulations showed low weight variation with dispersion time less than 90 seconds and rapid in vitro dissolution. The drug content of all the formulations was within the acceptable limits. The optimized formulation showed good release profile i.e. maximum drug being released at all-time intervals compared to other trial batches. It was concluded that fast dissolving tablets with improved dissolution could be prepared by dry granulation method of tablet.
Keywords: Aceclofenac, fast dissolving tablet, dry granulation, super disintegrants.
Individualized Homeopathic Treatment: Better Option in Management of Psoriasis
Authors: Agarwal Hiralal H , Jahagirdar Vilas L , Faroouqi Zeenat Fatima , Kelkar Onkar 
Published: October 2019

Psoriasis vulgaris is a cutaneous, inflammatory disease manifested by aberrant immune response mediated by T-lymphocytes. The disease is characterized by keratinocyte hyper proliferation, improper differentiation, angiogenesis and dermic vasodilatation. Psoriasis significantly affects the quality of patient’s life due toemotional stress. Sometimes patient may feel progressive mental depression and in turn seriously affecting his/hers family surrounding. The treatment approaches towards the successful management of psoriasis deserves consideration since the incidence of the disease is increasing now a days. Treating physicians should share their clinical experiences on global platform to benefit the patients effectively. Considering this aspect the present article describes some case studies of the management of Psoriasis with the help of homeopathic medicines.
Keywords: Homeopathy, Psoriasis, Dermatology, Skin Disease.
A Review on Nanoemulsions: A Recent Drug Delivery Tool
Authors: Changediya Vaibhav V , Jani Rupalben , Kakde Pradip 
Published: October 2019

There is a growing interest for using of nano/sub-micron particles in the technology of pharmaceutical, cosmetic and also food. Especially, this interest has been increasing parallel with better emulsification techniques and stabilization mechanisms. There are two main groups of nanoemulsion preparation methods, namely high-energy and low-energy spontaneous emulsification methods. Preparation processes and components used are significant parameters that affect stability from few hours to years. Problems such as creaming, coalescence sedimentation and flocculation are not concern for nanoemulsions due to their small droplet size. However, the main destabilization mechanism is Ostwald ripening for them. In this paper, a comprehensive review is presented to give basic ideas about nanoemulsions, their preparation methods, and evaluations.
Keywords: Nanoemulsion, preparation methods, evaluation
On the difficulties of evaluating the effect of school facility conditions on student outcomes
Authors: Hopland Arnt O. 
Published: October 2019

ABSTRACT
This paper presents various empirical strategies used to analyze the effect from school facilities on student outcomes, and discusses strengths and weaknesses by the methods. A key challenge in studies of student outcomes is that outcomes are affected by many factors and that many of these factors are correlated with each other. Moreover, some factors are difficult to measure, and cannot be observed in data. Hence, it is difficult to avoid problems related to omitted variables bias and the estimated correlations can thus often not be interpreted as causal effects. It is important to be aware of how difficult it is to move on from a correlation to a causal effect. If researchers wrongfully draw causal inferences one risks misleading policy makers into allocating resources to the wrong factors.
INSPECTING A BUMP TEST IN THE MAINTENANCE OF A 1200-CC DAIHATSU SIGRA DISC BRAKE
Authors: Subekti Subekti , Hamid Abdul , Effendy Basuki Dwi , Biantoro Agung Wahyudi 
Published: October 2019

A motorized vehicle needs a system that can not only reduce the speed and stop the vehicle but can also serve as a safety tool and ensure a safe distribution which is called a braking system. It is important to conduct maintenance of a disc brake that is part of the braking system. Therefore, this study developed a technique to inspect a 1200-cc Daihatsu Sigra disc brake through the vibration measurement using a bump test. A disc brake is comprised of three fields: A (located next to the center of the disc brake), B ( in the middle diameter), and C ( in the outer diameter of the disc brake). Each field has ten measurement points. This study showed that disc brake damages occurring in field A were at points 1-3, and they appeared after the 250-Hz frequency. Meanwhile, in fields B and C, at all measurement points, there were no changes taking place at any frequency.
IMPROVEMENT OF NETWORK SURVIVABILITY USING THE EFFECTIVE REDUNDANCY DESIGN
Authors: Dani Akhmad Wahyu , Sirait Fadli , Supegina Fina , Sahak Rohilah , Kusnanto Kresna Jery 
Published: October 2019

Network survivability is a very important issue due to the sustainability of the network services. Failure in a network system conduce to disturbance of the network services and causes trouble to millions of applications. Implement an effective redundancy design is one of method to cope nuisance in terms of sustainability in a network. In this paper, there are two design networks with and without redundancy respectively by Metro Ethernet-based technique to support transmission of data and voice. Furthermore, there is a validation performance of networks by measuring and comparing the throughput, latency and jitter between the two network designs. The value of bandwidth capacity is 100 Mbps as plan bandwidth link. Measurements results denote that network with redundancy design is able to enhance performance of the network, the parameters are: the throughput on single link tends to moderate (25%-50%), on the other hand, the throughput values on the main link and back uplink are in accordance with very good condition (75%-100%). The values of frame loss ratio 69.979% - 56.679% (single link), 6.77% -9.999% (main link) and 6.676 %-9.999% (back uplink). The values of jitter and latency in network with redundancy design are much better than in single link network. The recovery time for each frame length is ranging from 48.999ms to 49.887ms, where it is still meet with the standard that must below 50ms. Finally, when the main link in the network topology with redundancy design undergo link fails condition, the backup link is able to maintain the quality of network throughout that time, on the contrary, network topology without redundancy design is unable.
Financial Reporting Quality and Dual-Holding of Debt and Equity
Authors: Peyravan Leila 
Published: October 2019

ABSTRACT
I investigate whether the financial reporting quality (FRQ) of a firm influences the propensity of institutional investors to simultaneously hold the firm's debt and equity (dual-holding). I predict that the underlying reason for institutional dual-holding is access to the better information that is available to lenders in firms with low FRQ. Accordingly, I find that dual-holders are more likely to participate in firms with low FRQ. Additionally, I predict and find that dual-holders trade on the additional information received from borrowers. I find that dual-holders achieve excess returns of 8 percent on their trades in the borrower's equity, and that the direction of their trades predicts the direction of borrowers' news on the earnings announcement day. Finally, I demonstrate that dual-holders' trades generate excess returns only in firms with low FRQ, suggesting that investors become dual-holders in firms with low FRQ because informed trades in such firms offer higher returns.
JEL Classifications: G14; M41.
Do Type II Subsequent Events Impair Financial Reporting Quality?
Authors: Czerney Keith , Schmidt Jaime J. , Thompson Anne M. , Zhu Wei 
Published: October 2019

ABSTRACT
This study examines whether material corporate events that occur during the year-end closing process constrain management's and the auditor's resources and inhibit them from providing high-quality financial reports. For a sample of U.S. company financial reports issued during 2000–2013, we identify material corporate events using Type II subsequent event footnote disclosures (i.e., material events that occur in year t+1, but prior to the issuance of the year t financial statements, yet do not affect amounts recognized in year t). We find that Type II subsequent events are associated with lower financial reporting quality, as measured by the need to subsequently restate the year t financial statements. The increased restatement likelihood only occurs when managers are resource-constrained. Auditors can mitigate the increased restatement risk, but only when they allocate more resources to the engagement. Our results underscore the importance of resource management in the financial reporting and audit processes.
Competitividade das exportações brasileiras e colombianas de café
Authors: Copetti Leonardo Sangoi , Coronel Daniel Arruda 
Published: October 2019

O objetivo deste estudo foi o de analisar a competitividade das exportações brasileiras no mercado mundial do café, entre 2000 a 2018, em comparação ao terceiro produtor e exportador mundial, a Colômbia. Os dados foram coletados no site do USDA (United States Department of Agriculture), do UN COMTRADE (United Nations Comtrade), da FAO (Food and Agriculture Organization of the United Nations) e da WTO (World Trade Organization). A metodologia empregada baseou-se no Índice de Vantagem Comparativa Revelada Simétrica (VCRS), na Razão de Concentração (CR), e no Índice de Orientação Regional (IOR). Os resultados revelaram que tanto o Brasil quanto a Colômbia apresentaram vantagens comparativas para o café. Em relação à CR, o Brasil apresentou concentração e a Colômbia, desconcentração das exportações. O IOR indicou orientação das exportações de café do Brasil à Alemanha, à Itália, e aos Estados Unidos. Já o IOR da Colômbia apresentou orientação das exportações de café aos Estados Unidos, à Alemanha e ao Japão.
Palavras-Chave: Café. Competitividade. Exportações. Comércio Internacional.
Application of The New Shape Crushing Plate in Machine Crushing Processes
Authors: Ciężkowski Paweł , Maciejewski Jan , Bąk Sebastian , Kwaśniewski Arkadiusz 
Published: October 2019

Abstract
The results of studies of the crushing process in a double toggle jaw crusher are presented. This process was carried out on six sets of crushing plates. The first three of them are used in industrial crushers – plates with a flat working surface and a triangular profile (in this work, under consideration were profiles with teeth angle γ = 90°). The fourth and fifth type refer to plates with a variable pitch t and teeth height with a triangular shape of the teeth. In the sixth solution, plates with variable pitch and width of the wedged teeth are proposed.
The results of the basic process parameters are shown, that is, average degree of fineness n, technical performance Wt
, crushing energy L and crushing force F, sieve analysis of crushing product. The obtained results are the basis for the assessment of the suitability of various types of plates, especially plates with a new profile, which have an altered shape in comparison with the plates used in crushers so far.
The crushing tests were carried out with the same dimension of outlet slot er
= 24 mm, close to the pitch size for plates with triangular profile. Tests were performed on the “Mucharz” sandstone. Samples from a series of blocks of different size and geometric shape were prepared. This work also presents feed mass influence on crushing process efficiency.
The plates with variable pitch and width of teeth are beneficial because of lower crushing force and energy.
Validación de un instrumento para evaluar el estado de salud integral de universitarios
Authors: Valázquez Fernández Diana , Guerrero Alcocer Elvia Vianey , Pérez Garcés Ranulfo , Sánchez Repizo Yuridia , Márquez Molina Ofelia 
Published: October 2019

Promover la salud implica el cuidado de la salud no únicamente, la prevención o el tratamiento, significa su protección. La elaboración de instrumentos para la evaluación de salud es eje central en el diseño e implementación de estrategias de promoción y prevención. El objetivo fue diseñar y validar un instrumento para medir el estado de salud integral de universitarios. Se realizó una revisión bibliográfica de las variables: educación sexual, medio ambiente, estrés, nutrición, salud bucal, actividad física, género, inclusión, consumo de alcohol y tabaco con la finalidad de integrar la encuesta. Se diseñó un instrumento de 63 preguntas, fue aplicado en dos poblaciones de 96 universitarios. La varianza oscilo entre 0.71 - 4.89; el valor más bajo fue en consumo de alcohol y tabaco; y la más alta en actividad física. Conclusión el instrumento es confiable para determinar la salud integral de universitarios con un alfa de Cronbach>0.90.Palabras clave: Cuestionario, validación, autocuidado, empoderamiento, salud Promoting health implies not only health care, prevention or treatment, it means your protection. The development of instruments for health assessment is a central axis in the design and implementation of promotion and prevention strategies. The objective was to design and validate an instrument to measure the state of integral health of university students. A bibliographic review of the variables was carried out: sexual education, environment, stress, nutrition, oral health, physical activity, gender, inclusion, alcohol and tobacco consumption in order to integrate the survey. An instrument of 63 questions was designed, it was applied in two populations of 96 university students. The variance ranged from 0.71 - 4.89; the lowest value was in alcohol and tobacco consumption; and the highest in physical activity. Conclusion the instrument is reliable to determine the comprehensive health of university students with a Cronbach's alpha> 0.90.Keywords: questionnaire, validation, self-care, empowerment, health
Atributos de los estilos de vida que favorecen la salud en el personal de planta de la Universidad La Salle, Noroeste
Authors: Pérez Osuna Víctor Ulises 
Published: October 2019

En México se vive un aumento de las enfermedades crónicas no trasmisibles que afectan a la población laboral. Objetivo: Analizar las diferencias de los atributos del estilo de vida entre el personal sin riesgo y con riesgo de padecer obesidad, diabetes mellitus tipo 2 e hipertensión arterial. Método: Se estudiaron a 116 integrantes del personal de Universidad La Salle Noroeste (Hombres=67; Mujeres=49). Se evaluaron con el instrumento FANTÁSTICO, mediciones antropométricas y clínicas. Resultados: En la comparación de los grupos con riesgo y sin riesgo, el 30.2% de la población no presentó riesgo cardiovascular (RC), discriminando con el apoyo de la familia. Mientras que las funciones no discriminaron con la glucemia capilar y la presión arterial. Conclusiones: Se sugiere realizar acciones para promover el apoyo familiar, nutrición, el bajo consummo de alcohol y tabaco para generar estilos de vida saludable Palabras clave: estilos de vida; personal de planta; riesgo cardiovascular; hiperglicemia; hipertensión AbstractIn Mexico there is an increase in noncommunicable chronic diseases that affect the working population. Objective: To analyze the differences of the attributes of the lifestyle between the personnel without risk and with risk of obesity, diabetes mellitus type 2 and arterial hypertension. Method: 116 members of the staff of Universidad La Salle Noroeste (Men = 67, Women = 49) were studied. They were evaluated with the FANTASTIC instrument, anthropometric and clinical measurements. Results: In the comparison of the groups of risk and without risk, 30.2% of the population did not present CR, discriminating with the support of the family. While the functions did not discriminate with capillary blood glucose and blood pressure. Conclusions: It is suggested to carry out actions to promote variables such as family support, nutrition, low consumption of alcohol and tobacco to generate healthy lifestylesKeywords: Lifestyles, Plant Personnel, Cardiovascular Risk, Hyperglycemia, Hypertension
The Cancer Observatory of Cali, a priority
Authors: Abreu Claudia Patricia , Tobar Blandon María Fernanda , Holguín Jorge Alirio 
Published: October 2019

In the last issue of Colombia Médica, the Cali Population Registry of Cancer (RPCC, for its initials in Spanish) documented that important advances in cancer control have been achieved (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018818/). Mortality due to this group of diseases has decreased significantly during the last 25 years, thanks to the partial control of cancers related to infectious agents (stomach and cervix) and cancers associated with tobacco consumption (lung, bladder, oral cavity). However, there is less control of cancers related to screening activities (breast, prostate and colorectal), and hematolymphoid tumors that have successful treatment options with chemotherapy. As a result, cancer survival in children and adults is 20 percentage points below that observed in Europe and the United States 1.
One strategy to improve the indicators is the creation of a cancer observatory in the city. Health observatories are conceived as smart, proactive, dynamic, synchronic and participatory systems that generate knowledge for the formulation of policies and strategies that allow to impact, in a positive way, the social determinants of health (2). With this perspective and in congruence with the technical line of health observatories given by the Ministry of Health and Social Protection, it is necessary to generate strategies; to have articulation spaces; and to integrate sources of information, which in addition to being standardized and synchronized, facilitate the monitoring and identification of trends in the behavior of events, and the understanding and explanation of the health situation of the population based on complex analyses of inequalities and health vulnerabilities 2.
Task-Specific Sensitivity in Physical Function Testing Predicts Outcome in Patients With Low Back Pain
Authors: Trolle Nûno , Maribo Thomas , Jensen Lone Donbæk , Christiansen David Høyrup 
Published: October 2019

Objective To investigate the prognostic value of task-specific sensitivity in patients with low back pain by exploring whether task-specific sensitivity during physical function testing was associated with self-reported change in pain and disability. Design Prospective cohort study nested in a randomized controlled trial. Methods The study included 260 patients with low back pain, referred for evaluation in a secondary care setting. All patients completed questionnaires and underwent clinical examination by a physical therapist. Patients rated their pain intensity before and after completing a test battery measuring physical function and were classified into 4 categories—worse, unchanged, better, or no pain—depending on their pain response. At 3-month follow-up, outcomes were obtained by a postal questionnaire. Results Task-specific sensitivity significantly predicted pain, after adjusting for known prognostic factors. Patients in the no pain, better, and unchanged groups improved their pain score significantly more than patients in the worse pain group. Patients in the no pain group also improved their disability score significantly more compared to patients in the worse pain group, after adjusting for known prognostic factors. Conclusion Task-specific sensitivity predicted pain intensity after 3 months in patients with low back pain. The prognostic value appears limited with respect to disability. J Orthop Sports Phys Ther 2020;50(4):206–213. Epub 30 Oct 2019. doi:10.2519/jospt.2020.8953
Pengaruh Organizational Citizenship Behaviour (OCB) Terhadap Kinerja Karyawan (Studi Pada Pt. Urchindize Cabang Madura)
Authors: Abrar Unsul , Isyanto Isyanto 
Published: October 2019

Organisasi laba atau dalam hal ini adalah perusahaan ynag berkecimpung dalam dunia bisnis perlu untuk selalu mengevaluasi diri untuk bagaimana bertahan dalam persaingan yang sangat kompettitf tersebut serta dituntut untuk selalu melakukan perubahan atau pembenahan untuk kelangsungan dan perkembangan organisasi yang lebih efektif dan efisien. Oleh karenanya Perusahaan harus mampu dan bisa mempertahankan kinerja perusahaan ataupun perusahaan secara keseluruhan dan dapat mengembangkan ataupun meningkatkan kinerja pada setiap karyawan, perilaku OCB adalah merupakan kinerja yang diharapkan mampu merubah fenomena yang terjadi di dunia kerja dengan mengedepankan saling memahami dan toleransi yang tinggi antar karyawan, adapun populasi yang akan menjadi objek penelitian ini adalh PT.Urchindize Indonesia Madura yang selama ini bergerak dibidang perikanan. Data penelitian diperoleh dari beberapa kuesioner yang telah disebarkan dengan teknik pengumpulan data diimplementasikan berupa pemberian beberapa pertanyaan atau pernyataan tertulis terhadap sejumlah responden untuk bisa dijawab. Skala Likert digunakan dalam mengukur beberapa kuesioner yang berupa pernyataan seseorang tentang pengaruh OCB terhadap kinerja perusahaan. Hasil penelitian menyimpulkan bahwa dari beberapa indikator yang dipakai dalam penilaian tersebut bahwa nilai dari konstantanya sebesar 17,338 dan nilai koefisien dari variabel organizational citizenship behavior sebesar 0,294 serta memiliki nilai signifikan dibawah 0,05 sehingga jika variabel organizational citizenship behavior naik, maka variabel kinerja perusahaan juga akan bertambah 0,294