bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colonization potential of plantaricin-producing Lactobacillus plantarum SF9C and S-layer carrying Lactobacillus brevis SF9B among gut microbiota
Authors: Butorac Katarina , Banic Martina , Novak Jasna , Pavunc Andreja Leboš , Uroic Ksenija , Orsolic Nada , Kukolj Marina , Radovic Slobodanka , Scalabrin Simone , Zucko Jurica , Starčevic Antonio , Suskovic Jagoda , Kos Blaženka 
Published: February 2020

Abstract
Background: The influence of an S-layer carrying Lactobacillus brevis SF9B and plantaricin-producing Lactobacillus plantarum SF9C on the gut microbiota composition was evaluated in the rats. Considering the probiotic potential of Lb. brevis SF9B, this study aimed to examine the antimicrobial activity of Lb. plantarum SF9C and potential for their in vivo colonization, which could be the basis for the investigation of their synergistic functionality. Results: We identified plantaricin encoding cluster in Lb. plantarum SF9C, a strain which efficiently inhibited Listeria monocytogenes ATCC®19111™ and Staphylococcus aureus 3048. Contrary to a plantaricin-producing SF9C strain S-layer carrying SF9B strain excluded Escherichia coli 3014 and Salmonella enterica serovar Typhimurium FP1 from Caco-2 cells. DGGE analysis of the V2-V3 region of the 16S rRNA gene confirmed the transit of the two selected lactobacilli through the gastrointestinal tract. Microbiome profiling via the Illumina MiSeq platform revealed the prevalence of Lactobacillus spp. in the gut microbiota of rats suggesting their colonization potential in GIT.Conclusion: The combined application of the two strains could influence intestinal microbiota composition, which is reflected through the increased abundance of Lactobacillus genus, but also along with the abundances of other bacterial genera, either in the model of health or aberrant microbiota. Obtained results contribute to the functional aspect of SF9C and SF9B strains which could be incorporated in the probiotic-containing functional foods to beneficially influence gut microbiota composition.
Exploring the influence of maternally derived antibody against hepatitis B surface antigen on infants’ immune response to hepatitis B vaccine in mice
Authors: Lv Weihong , Wei Tao , Tan Shanjuan , Li Ling , Teng Jijun , Qi Hong , Han Tongliang , Zhang Lei 
Published: February 2020

Abstract
Background: Whether maternal anti-HBs acquired transplacentally plays a negative role in newborn infants’ immune response to hepatitis B vaccine (HepB Vac), it remains controversial and has not been paid enough attention.Methods: 267 BALB/c mice were bred. All mice were divided into two groups according to different doses of HepB Vac (2μg, 5μg) injected to mice. Each group was sub-divided into three subgroups according to different doses of hepatitis B immunoglobulin (HBIG) (50 IU, 25 IU, 0 IU) injected combined with the first dose of HepB Vac. Three doses of HepB Vac were administrated at 0 week, 4week and 8 week respectively. Antibodies against hepatitis B surface antigen (anti-HBs) were tested four weeks after the third dose of HepB Vac.Results: Among 267 mice, 40 were of low- and non-response to HepB Vac (anti-HBs<100 mIU/mL). Multivariate logistic regression analysis showed that rates of anti-HBs<100 mIU/mL were: 1.1%, 23.1% and 20.7% in groups of HBIG=0 IU(1), HBIG=25 IU(2) and HBIG=50 IU(3) respectively, p = 0.002, and among subgroups, (1) vs (3), RR= 0.032, 95% CI [0.004, 0.255], p = 0.001, (2) vs (3), RR= 1.359, 95% CI [0.588, 3.144], p = 0.473; 4.5% and 25.6% in groups of HepB Vac 5μg and 2μg, RR=0.093, 95% CI [0.035, 0.250], p <0.001; 6.1% and 23.7% in groups of intramuscular injection and hypodermic injection, RR=0.139, 95% CI [0.056, 0.346], p <0.001. The mean titers of anti-HBs (log10mIU/m) were on the decrease in turn in groups of HBIG= 0 IU, HBIG= 25 IU and HBIG= 50 IU, p <0.001.Conclusions: HBIG has a negative impact on both the rate of effective immune response and response level of anti-HBs, which preliminarily indicates maternal anti-HBs inhibits infants’ immune response to HepB Vac.
The Harris Hip Score
Authors: Khaja ALIAA , AL-Mutairi Owayed , Alkhudair abdulaziz , Abdulkarim Awdhah 
Published: February 2020

Abstract
Background The Harris Hip Score (HHS) is a widely used Patient-Related Outcomes score. It measures pain and function levels in patients with hip pathologies. Objectives The main objective of this study is to translate and culturally adapt the HHS into Arabic, and to further assess the reliability and validity of translated version Material & Methods 110 patients participated in this survey. The internal consistency tests were performed using Cronbach’s alpha. Test-retest reliability (intra-correlation coefficient), convergent construct validity, convergent validity, floor & ceiling effects and responsiveness was also calculated. In order to measure the level of agreement, Bland-Altman Plot, forest Plots are performed. Results Test reliability for the first testing situation - calculated using Cronbach's alpha - was 0.98 for the pain subscale, 0.98 for the stiffness, and 0.99 for the physical function subscale. For the second testing, reliability was 0.99, 0.97, and 0.99 (pain, stiffness, and physical function, respectively). This only proves that WOMAC is an instrument with good reliability. Same calculation of Cronbach’s alpha was essential to testing the reliability of the Harris Hip Score. For each of the three testing occasions the reliability was very good or excellent – α 1 = 0.92, α 2 = 0.91, and α 3 = 0.90. Intra-class correlation coefficient was good with the score of 0.76 (95% CI 0.44-0.88). Conclusion Overall, Arabic version of HOOS could be used as diagnostic tool for patients with hip problems, when it comes to information about the overall condition of the patient, especially about the improvement or deterioration, however, it is important to be cautious using HHS when the change magnitude of patient’s condition is investigated, since there is a potential probability that the level of improvement of the patient’s condition will be overestimated by HHS.
The risk to develop tuberculosis and efficacy of its preventive treatment in labor migrants residing in the Republic of Tajikistan
Authors: Bobokhodzhaev O. I. , Radzhabzoda A. S. , Mirzoeva F. O. , Sharipov F. R. , Aliev S. P. , Ali-Zade S. G. 
Published: February 2020

Objective: to study the prevalence of latent tuberculosis infection (LTBI), risk factors for LTBI to develop into active tuberculosis, the efficacy of preventive treatment in those with LTBI among labor migrants, residing in the Republic of Tajikistan.Subjects and methods. In the Republic of Tajikistan, 500 residents were followed up as Main Group, they all were labor migrants for more than 3 months and returned to their homeland within one year before inclusion in this study. All of them participated in a questionnaire survey to identify risk factors for developing tuberculosis and had the examination that included Mantoux test with 2 TE and chest X-ray. Comparison Group (CG) consisted of 500 citizens of compatible gender and age who did not travel as labor migrants; they all participated in the same survey and had the same examination.Results. The positive results of Mantoux test with no abnormalities on X-ray were observed in 40% of people in Main Group and 33.4% of people in Comparison Group.The following factors were found to be more frequent in Main Group versus Comparison Group, respectively: frequent and continuous exposure to a TB case – 78.2 and 23.1% (p < 0.01); no tuberculosis prevention – 83.1% and 48.4% (p < 0.01); poor accommodation and work conditions 87.9 and 13.6% (p < 0.01); inadequate diet and lack of proper clothes – 79.4 and 24.3% (p < 0.01); limited access to medical care – 85.4 and 22.6% (p < 0.01). MG was found to have a higher summarized risk coefficient (r = 4.75) versus CG (r = 2.0), p < 0.01. During 2–3-year follow-up of those with LTBI who had no preventive treatment with isoniazod, tuberculosis was diagnosed in 44.4% of people from MG and 18.5% of people from CG. The introduction of the integrated approach to tuberculosis control among people preparing for labor migration allowed reducing the proportion (from 19.7 to 13.7%) of labor migrants in the structure of TB incidence.
Experimental constraints on the partial melting of sediment-metasomatized lithospheric mantle in subduction zones
Authors: Zhang Yanfei , Liang Xuran , Wang Chao , Jin Zhenmin , Zhu Lüyun , Gan Wei 
Published: February 2020

AbstractSedimentary diapirs can be relaminated to the base of the lithosphere during slab subduction, where they can interact with the ambient lithospheric mantle to form variably metasomatized zones. Here, high-pressure experiments in sediment-harzburgite systems were conducted at 1.5–2.5 GPa and 800–1300 °C to investigate the interaction between relaminated sediment diapirs and lithospheric mantle. Two end-member processes of mixed experiments and layered (reaction) experiments were explored. In the first end-member, sediment and harzburgite powders were mixed to a homogeneous proportion (1:3), whereas in the second, the two powders were juxtaposed as separate layers. In the first series of experiments, the run products were mainly composed of olivine + orthopyroxene + clinopyroxene + phlogopite in subsolidus experiments, while the phase assemblages were then replaced by olivine + orthopyroxene + melt (or trace phlogopite) in supersolidus experiments. Basaltic and foiditic melts were observed in all supersolidus mixed experiments (~44–52 wt% SiO2 at 1.5 GPa, ~35–43 wt% SiO2 at 2.5 GPa). In the phlogopite-rich experiment (PC431, 1.5 GPa and 1100 °C), the formed melts had low alkali contents (~&lt;2 wt%) and K2O/Na2O ratios (~0.4–1.1). In contrast, the quenched melt in phlogopite-free/poor experiments showed relatively higher alkali contents (~4–8 wt%) and K2O/Na2O ratios (~2–5). Therefore, the stability of phlogopite could control the bulk K2O and K2O/Na2O ratios of magmas derived from the sediment-metasomatized lithospheric mantle. In layered experiments, a reaction zone dominated by clinopyroxene + amphibole (or orthopyroxene) was formed because of the reaction between harzburgite and bottom sediment-derived melts (~62.5–67 wt% SiO2). The total alkali contents and K2O/Na2O ratios of the formed melts were about 6–8 wt% and 1.5–3, respectively. Experimentally formed melts from both mixed and reaction experiments were rich in large ion lithosphile elements and displayed similar patterns with natural potassium-rich arc lavas from oceanic subduction zones (i.e., Mexican, Sunda, Central American, and Aleutian). The experimental results demonstrated that bulk sediment diapirs, in addition to sediment melt, may be another possible mechanism to transfer material from a subducting slab to an upper mantle wedge or lithospheric mantle. On the other hand, the breakdown of phlogopite may play an important role in the mantle source that produces potassium-rich arc lavas in subduction zones.
Pemberdayaan Siswa Madrasah Aliyah Melalui Pelatihan Chemoentrepreneurship Lilin Hias Aromaterapi
Authors: Prayitno Mohammad Agus , Amalana Husna 
Published: February 2020

<p>Islamic Senior High School of Mu'allimin Mu'allimat Rembang (MA M3R) is one of the oldest school in Rembang Regency. Most of the students who attend the school are students from various Islamic boarding schools in the city of Rembang. Most of the graduates from MA M3R did not continue to Higher Education. There are those who work, get married, and those who continue chanting. For this reason, counseling activities are needed which are to provide training to MA M3R students who aim to equip entrepreneurial skills after graduation. One of the entrepreneurial skills that can be delivered is the making of aromatherapy decorative candles. The stages in the extension activities include 3 stages, namely preparation, implementation and evaluation. This service activity is able to increase student entrepreneurial motivation, train students' tenacity and responsibility, and train good ways of communicating when marketing product results.<strong></strong></p><p> </p><p>Madrasah Aliyah Mu’allimin Mu’allimat Rembang (MA M3R) merupakan salah satu madrasah tertua di Kabupaten Rembang. Sebagian besar siswa yang bersekolah di madarah tersebut adalah santri dari berbagai pondok pesantren yang ada di kota Rembang. Sebagian besar lulusan dari MA M3R tidak melanjutkan ke Perguruan Tinggi. Ada yang bekerja, menikah, dan adapula yang melanjutkan mengaji. Untuk itu diperlukan kegiatan penyuluhan yang sifatnya memberikan pelatihan terhadap siswa-siswi MA M3R yang bertujuan untuk membekali keterampilan wirausaha setelah lulus. Salah satu keterampilan wirausaha yang dapat disampaikan adalah pembuatan lilin hias beraromaterapi. Tahapan dalam kegiatan penyuluhan ini meliputi 3 tahap, yaitu persiapan, pelaksanaan, dan evaluasi. Kegiatan pengabdian ini mampu meningkatkan motivasi wirausaha siswa, melatih keuletan dan tanggung jawab siswa, serta melatih cara berkomunikasi yang baik pada saat memasarkan hasil produk.<strong></strong></p>
Transformasi Dan Optimalisasi Potensi Masjid Daerah Ujung Utara Kabupaten Tasikmalaya
Authors: Jamal Moh Yusup Saepuloh , Somantri Muhamad Dani , Al-Fauzi Cecep Moch. Ramli 
Published: February 2020

<p>Mosque has a pivotal role in the process of Da’wah for Muslim, including al-Barokah Mosqu, Guranteng, Tasikmalaya. This transformative research aims at transforming people's perception in understanding the substance of the role and function of mosques and optimizing the potential of the mosque to its fullest. This Participatory Action Research model links the social change process through three-area of empowerment : Community commitment, local leader, and institutional based needs. The results of the study gained action of change: Seeking the transformation of community paradigms on understanding the substance role of the mosque through several actions: FGD for restructuring DKM Management, strengthening DKM and DKM management training. Meanwhile, the second stage is to optimize the potential of the culture by implementing the mosque empowerment based on local culture, such as the training of Friday's cermon, corpes-handling management, Ziswaf Manager, reading <em>Marhabaan</em>, forming youth-mosque-managers, as well as assistance by other potential-based empowerment activities.</p><p> </p><p>Secara substansi masjid mempunyai peran sentral yang sangat penting terhadap laju perjalanan dakwah umat Islam. Peran sentral masjid kenyataannya tidak berbanding lurus dengan keberadaan masjid al-Barokah daerah ujung utara Kabupaten Tasikmalaya. Penelitian transformatif ini bertujuan untuk mentransformasi persepsi masyarakat dalam memahami substansi peran dan fungsi masjid dan mengoptimalisasikan potensi masjid secara maksimal. Penelitian ini menggunakan model <em>participatory action research</em> yang menghubungkan proses perubahan sosial melalui tiga pemberdayaan: komitmen masyarakat, <em>local leader</em>, dan institusi berdasarkan kebutuhan. Dari hasil penelitian diperoleh aksi perubahan: mengupayakan transformasi paradigma masyarakat terhadap pemahaman substansi peranan fungsi masjid yang diupayakan melalui beberapa <em>action</em>: refleksi FGD merestrukturisasi pengurus DKM, pengukuhan pengurus DKM; dan pelatihan manajemen DKM.Sementara tahap kedua melakukan langkah optimalisasi terhadap potensi yang dimiliki dengan menerapkan pemberdayaan masjid berbasis lokalitas budaya, seperti pelatihan khutbah Jum’at, pengurusan jenazah, pengelola Ziswaf, membaca <em>marhabaan</em>, pembentukan pengurus remaja/pemuda masjid, serta dampingan kegiatan pemberdayaan lainnya berbasis potensi.</p>
Application of D-optimal Mixture Design for Development and Optimization of Olmesartan Medoxomil Loaded SMEDDS
Authors: Gahlawat Navdeep , Verma Ravinder , Kaushik Deepak 
Published: February 2020

Background:
Olmesartan medoxomil is an angiotensin II receptor blocker
antihypertensive drug, which has low oral bioavailability because of poor aqueous solubility.

Objective:
The objective of the present research is the development and optimization of Olmesartan
medoxomil loaded self-micro emulsifying drug delivery system by D-optimal mixture design to
improve its dissolution rate.

Methods:
Solubility of Olmesartan medoxomil was determined in different oils, surfactants and cosurfactants.
The pseudo ternary diagram was constructed for the identification of self-micro
emulsification region. The D-optimal mixture design was employed for the optimization of SMEDDS
formulations wherein the factors optimized were the concentration of oil (X1), surfactant (X2), and
co-surfactant (X3) and the response was globule size (Y1) and dissolution rate (Y2). Developed selfmicroemulsifying
drug delivery system was further assessed for self-emulsification time, drug
loading capacity, transparency, globule size, in vitro dissolution and comparative in vitro dissolution
testing of optimized formulation with pure medicament and commercially available product.

Results:
The application of D-optimal mixture design resulted in 14 batches out of which F-5 was
found to be the optimized batch which contained Olmesartan medoxomil (20 mg), Capmul MCM
EP (23% v/v), Kolliphore EL (49% v/v) and Transcutol P (28% v/v) having globule size of 105 nm,
94.7% dissolution within 30 minutes. In vitro dissolution rate of the drug from SMEDDS was
appreciably higher than that of pure drug and marketed products.

Conclusion:
Olmesartan medoxomil self-microemulsifying drug delivery system was successfully
developed and this approach could prove to be suitable for the improvement of the dissolution rate
of BCS II class drugs.
Correlation Between Non-Alcoholic Fatty Liver and Chronic Kidney Disease
Authors: Kasim Hasyim , Zatalia St. Rabiul , Rasyid Haerani , Bakri Syakib , Parewangi Muhammad L. , Akil Fardah , Seweng Arifin 
Published: February 2020

Background:
NAFLD is an independent risk factor of CKD. CKD prevalences in NAFLD subjects are two times higher than non-NAFLD. The aim of this study is to know the correlation between NAFLD and CKD.

Methods:
Cross-sectional study was conducted on patients who held Abdominal USG in Wahidin Sudirohusodo & UNHAS hospital from January to December 2017. NAFLD subjects are male and female (18-60 years) who met NAFLD criteria and wanted to participate, non-NAFLD as control subjects. NAFLD is fat accumulation in hepatocyte without a history of alcohol consumption or other etiology of chronic liver disease. CKD definition and classification were based on KDIGO 2012. P value <0.05 was considered to be significant.

Results:
From the study period, we found 134 subjects (67 NAFLD subjects and 67 non-NAFLD subjects). Correlation analysis between NAFLD and eGFR showed that NAFLD subjects had more proportion of eGFR <60 ml/min/1.73m2 than non-NAFLD subjects (40.3% vs 16.4%, p=0.002). NAFLD subjects significantly had more proportion of CKD Grade 3 than non-NAFLD subjects (37.3% vs 9%) while non-NAFLD subjects had more proportion of CKD Grade 1 and 2 than NAFLD subjects (56.7% vs 38.8% dan 26.9% vs 20.9%)(p=0.001). Correlation analysis between NAFLD and proteinuria did not show significant results (p=0.051).

Conclusion:
NAFLD subjects correlated with CKD events compared with non-NAFLD subjects.
Perbuatan pidana kesusilaan dalam rancangan undang-undang KUHP
Authors: Hartini Sri 
Published: February 2020

As an independent and sovereignty country, Indonesia should arrange KUHP (Kitab Undang-Undang Hukum Pidana) to avoid loss of criminalities that have been increasing. The renewal of KUHP is very needed because it's not proper with the values of social politic, social philosophy, and social cultural of Indonesia people. It is the basic for sosial, criminal policy, and law enforcement. The urgency of revising of KUHP, specially putting susila crime put in draft criminal code (RUU KUHP) and almost the requirement still be formed widely, not distinguishing between criminal and people who break the rule, but the words "susila Crime” and the newly "statutory rape" and "incest’. According to the renewal, it's needed to direct it into the law development that is democratic and responsive, so that the law's function-that protect the society, can give fairness and as a development instrument will raise suitable with the principle of law country. Although the draft criminal code (RUU KUHP) still need to be discussed again, remembering the effort to have national KUHP is very urgent, so it's better that draft criminal code (RUU KUHP) is not need more time to be UU, in the other hand, technically we will face difficulties in law enforcement because the representatives and experts are more free to say their thoughts.
Pendidikan Kewarganegaraan persekolahan: standar isi dan pembelajarannya
Authors: Winarno Winarno 
Published: February 2020

The content standard of civic education for the elementary level and junior high level consist of minimum materials and minimum competency, there are standard competency and basic compe­tency of civic education subject that should be studied by the students. The next definition of contain standard is to arrange Curriculum of Educational Level, syllabi, and Study Imple­mentation Planning. The Civic Education learning stand on the process standard that is the learning process that done interactively, inspirationally, fon, challenging, motivating the student to be actively participated; and also give enough spaces for the initiates, creatively, and indepen­dency based on the talent, enthusiasm, and the student physical and development: Substantially, the Civic Education contains, according to the contain standard are similar with the subject contain of the Civic Education based on the 2004 Curriculum. Thereby, the Civic Education teachers can use the 2004 Civic Education Curriculum guide in order to develop the materials and the school Civic Education Learning.
PEMILIHAN KEPALA DAERAH DALAM PERSPEKTIF PERAN PENDIDIKAN KEWARGANEGARAAN Pemilihan kepala daerah dalam perspektif Pendidikan Kewarganegaraan
Authors: Cholisin Cholisin 
Published: February 2020

Civic Education is an important component ofeducation of democracy, because itfosters citizen's participation within public daily life, in fonn ofpolitical participation, e.g. in election of head oflocal (llgencylprovence) guvemment-abbreviated into Pilkada for indirect election and Pilkadal for direct election by people. This paper focuses on implementation ofrole of Civic Education in context of Pilkadal Through Civic Education, citizen is preparated to be rational voter, learn on democracy through democratic institution, e.g. Pilkadal Effectivity of Civic Education well be influenced by whether candidates contribute to strengthen rational-calctdatiue voting behavior or precisely foster emotional one. Pilkadal will be meaningful when it plays a role in fonn of the first So that; candidates should learn and then peform behavior according to what is striven in Civic Education. Finally, they could become a good "teacher". ofa political education through Pilkadal