bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monocytic Infiltrates Contribute to Autistic-like Behaviors in a Two-Hit Model of Neurodevelopmental Defects
Authors: Chen Hong-Ru , Chen Ching-Wen , Mandhani Nandita , Short-Miller Jonah C. , Smucker Marchelle R. , Sun Yu-Yo , Kuan Chia-Yi 
Published: October 2020

Growing evidence suggests that early-life interactions among genetic, immune, and environment factors may modulate neurodevelopment and cause psycho-cognitive deficits. Maternal immune activation (MIA) induces autism-like behaviors in offspring, but how it interplays with perinatal brain injury (especially birth asphyxia or hypoxia ischemia [HI]) is unclear. Herein we compared the effects of MIA (injection of poly[I:C] to dam at gestational day 12.5), HI at postnatal day 10, and the combined MIA/HI insult in murine offspring of both sexes. We found that MIA induced autistic-like behaviors without microglial activation but amplified post-HI NFκB signaling, pro-inflammatory responses, and brain injury in offspring. Conversely, HI neither provoked autistic-like behaviors nor concealed them in the MIA offspring. Instead, the dual MIA/HI insult added autistic-like behaviors with diminished synaptic density and reduction of autism-related PSD-95 and Homer-1 in the hippocampus, which were missing in the singular MIA or HI insult. Further, the dual MIA/HI insult enhanced the brain influx of Otx2-positive monocytes that are associated with an increase of perineuronal net-enwrapped parvalbumin neurons. UsingCCR2-CreERmice to distinguish monocytes from the resident microglia, we found that the monocytic infiltrates gradually adopted a ramified morphology and expressed the microglial signature genes (Tmem119, P2RY12, and Sall1) in post-MIA/HI brains, with some continuing to express the proinflammatory cytokine TNFα. Finally, genetic or pharmacological obstruction of monocytic influx significantly reduced perineuronal net-enwrapped parvalbumin neurons and autistic-like behaviors in MIA/HI offspring. Together, these results suggest a pathologic role of monocytes in the two-hit (immune plus neonatal HI) model of neurodevelopmental defects.SIGNIFICANCE STATEMENTIn autism spectrum disorders (ASDs), prenatal infection or maternal immune activation (MIA) may act as a primer for multiple genetic and environmental factors to impair neurodevelopment. This study examined whether MIA cooperates with neonatal cerebral hypoxia ischemia to promote ASD-like aberrations in mice using a novel two-hit model. It was shown that the combination of MIA and neonatal hypoxia ischemia produces autistic-like behaviors in the offspring, and has synergistic effects in inducing neuroinflammation, monocytic infiltrates, synaptic defects, and perineuronal nets. Furthermore, genetic or pharmacological intervention of the MCP1-CCR2 chemoattractant pathway markedly reduced monocytic infiltrates, perineuronal nets, and autistic-like behaviors. These results suggest reciprocal escalation of immune and neonatal brain injury in a subset of ASD that may benefit from monocyte-targeted treatments.
On I. A. Bunin’s Story The Date and the Dedication to “M. P. Ch.”
Authors: Ivanova Natalia 
Published: November 2020

This article publishes a little-known story by I. A. Bunin in 1902 – The Date – with the dedication “M. P. CH.”, stored in the personal archive of Maria Pavlovna Chekhov. An attempt is made to trace the author’s changes in the story to 1907, which made it possible to remove the dedication and change the original title to Happiness. This edit did not suit Bunin; in Paris he once again changes the text of the story, giving a different name – Dawn All Night. Not only is the text of the story Happiness based on the 1907 collection Korabli, but the place of its publication is specified.
History is Human Destinies
Authors: Brio Valentine 
Published: November 2020

Профессор Елена Петровна Червинскене (Elena Červinskienė), руководившая кафедрой Русской литературы Вильнюсского университета с 1984 по 1989 г., – автор ряда исследований, посвященных русской классической литературе, среди которых книги о Федоре Достоевском (Dostojevskis, 1971), Антоне Чехове (Единство художественного мира: А. П. Чехов, 1976), Льве Толстом (Levo Tolstojaus meno pasaulyje, 1978; По закону Льва Толстого, 1992), хрестоматии по русской эстетической и критической мысли Apie literatūros esmę: XVIII–XIX a. rusų estetinė ir kritinė mintis (1988), статьи и выступления о творчестве Михаила Салтыкова-Щедрина, Николая Некрасова, Ивана Тургенева, Александра Герцена, Афанасия Фета. Но среди многочисленных работ одна ее книга стоит совершенно особняком.
В июне 1941 г. Е. П. Червинскене оказалась среди тех 17 500–18 000 жителей Литвы, которые были депортированы в Сибирь или другие места ссылки. Об этой трагической части своей жизни Червинскене рассказала в книге воспоминаний Silpnųjų jėga (Vilnius: Vaga, 1995), которая четыре года спустя вышла и на русском языке (Сила слабых. Воспоминания. Пер. с лит. А. Кондюриной. Москва: Диалог-МГУ, 1999). В память о Е. П. Червинскене мы публикуем рецензию В. Брио на эту книгу. Рецензия появилась в одной из газет Литвы сразу после выхода мемуаров на литовском языке.
Aktivitas Antioksidan Ekstrak Etanol Kamboja Jepang (Adenium obesum) dan Kamboja Putih (Plumeria acuminata)
Authors: Shofi Muh. , Suwitasari Fera , Istiqomah Nurul 
Published: October 2020

AbstrakSenyawa antioksidan adalah senyawa yang dapat menangkal dampak radikal bebas dengan cara menghambat stres oksidatif serta menghentikan kerusakan sel dan induksi penyakit. Tanaman kamboja jepang (Adenium obesum) dan kamboja putih (Plumeria acuminata) termasuk tanaman hias yang memiliki khasiat obat. Tanaman ini banyak mengandung senyawa flavonoid dan senyawa antioksidan alami. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan ekstrak etanol daun dan bunga tanaman kamboja jepang dan kamboja putih. Ekstrak kamboja diperoleh dengan melakukan maserasi daun dan bunga kamboja dengan menggunakan pelarut etanol 70% dan 96%. Ekstrak kental daun dan bunga kamboja diperoleh dengan cara pemekatan ekstrak menggunakan penangas air. Uji skrining fitokimia ekstrak kental berupa kandungan alkaloid, saponin, tanin, flavonoid, terpenoid, dan steroid secara kualitatif, sementara aktivitas antioksidan diuji dengan metode 2,2-diphenyl-1-picrylhydrazyl (DPPH). Hasil skrining fitokimia ekstrak menunjukkan adanya kandungan alkaloid, tanin, flavonoid, dan saponin dengan nilai IC50 tertinggi ditunjukan oleh ekstrak bunga kamboja putih yang diekstrak dengan etanol 70% yaitu sebesar 98,41 ppm, dan terendah oleh bunga kamboja putih yang diekstrak dengan etanol 96% yaitu 533,13 ppm. Ekstrak etanol tanaman kamboja jepang dan kamboja putih memiliki potensi sebagai antioksidan alami.Abstract Antioxidant compounds are compounds that can counteract the effects of free radicals by inhibiting oxidative stress and stopping cell damage and disease induction. Japanese frangipani plants (Adenium obesum) And white frangipani (Plumeria acuminata), including ornamental plants that have medicinal properties. This plant contains a lot of flavonoid compounds and natural antioxidant compounds. This study aims to determine the antioxidant activity of ethanol extracts of leaves and flowers of japanese frangipani plants and white frangipani. Frangipani extract is obtained by moderating frangipani leaves and flowers by using 70% and 96% ethanol solvents. Thick extracts of frangipani leaves and flowers are obtained by concentrating the extract using a water bath. Phytochemical screening tests of thick extracts containing alkaloids, saponins, tannins, flavonoids, terpenoids, and steroids qualitatively, while antioxidant activity was tested by the method 2,2-diphenyl-1-picrylhydrazyl (DPPH). Phytochemical screening results showed the presence of alkaloids, tannins, flavonoids, and saponins with the highest IC50 values shown by white frangipani extract extracted with 70% ethanol at 98.41 ppm, and the lowest by white frangipani extracted with 96% ethanol at 533.13 ppm. Ethanol extract of japanese frangipani and white frangipani plants have potential as natural antioxidants.
Potential of Cibodas Botanical Garden Fern and Lycophytes Collection as the Source of Medicine
Authors: Nikmatullah Muhamad , Rwnjana Elga , Muhaimin Muhamad , Rahayu Mulyati 
Published: October 2020

AbstrakKebun Raya Cibodas (KRC) merupakan kawasan konservasi tumbuhan secara ex-situ yang berfokus untuk mengkonservasi tumbuhan dataran tinggi basah, mencakup tumbuhan langka dan tumbuhan bermanfaat. Salah satu koleksi penting KRC adalah koleksi tumbuhan paku yang telah diketahui memiliki beragam manfaat, seperti sumber obat. Akan tetapi, potensinya sebagai sumber obat belum pernah dikaji lebih lanjut. Penelitian ini bertujuan untuk melakukan inventarisasi dan analisis terhadap koleksi tumbuhan paku KRC yang bernilai obat berdasarkan kajian literatur yang terkait dengan etnomedisin. Berdasarkan hasil kajian, sebanyak 38 jenis dari 29 marga dan 22 suku dari koleksi tumbuhan paku KRC telah diketahui manfaatnya sebagai obat. Suku Athyriaceae memiliki perwakilan jenis paling banyak yang memiliki khasiat obat, yaitu lima jenis. Terdapat 20 jenis koleksi tumbuhan paku KRC paling umum digunakan sebagai obat penutup luka dan penyakit akibat infeksi parasit. Daun dari 18 jenis merupakan bagian yang paling sering digunakan untuk pengobatan. Koleksi tumbuhan paku KRC berpotensi besar untuk dikembangkan sebagai sumber obat di masa mendatang. Berbagai upaya perlu dilakukan untuk mengembangkan potensi tersebut, antara lain perbanyakan koleksi dan uji aktivitas farmakologi senyawa aktif.Abstract Cibodas Botanical Garden (CBG) is an ex-situ plant conservation area that focuses on the conservation of mountain wet plants, including rare and useful plants. One of the important collections of CBG is ferns and lycophytes which have various benefits, such as a medicinal source. However, its potential as a medicinal source has not been studied further. This study aims to conduct an inventory and analysis of CBG’s ferns and lycophytes collection that have medicinal potential based on literature related to ethnomedicin. The results showed that CBG has 38 species, 29 genera, and 22 families of ferns and lycophytes collection that have known as medicine. The Athyriaceae group has the most representative species of medicinal properties, which are about five species. There are 20 species of CBG’s ferns and lycophytes collection were most commonly found as medicine for wounds and infectious diseases. The leaves from 18 species of ferns and lycophytes collection are most frequently used for disease medication. The CBG’s ferns and lycophytes collection has great potential to be developed as medicinal sources in the future. Various efforts are needed to develop the potential of ferns and lycophytes collection, such as increasing collections and studying the pharmacological activity of their active compounds.
Novel fenofibrate adverse effect in resistant hypertension: A case report
Authors: Barrouq Deena M. S. , Irshaidat Tareq 
Published: October 2020

Background: Silent uncontrolled hypertension can cause major organ damage.
Case presentation: A 42-year-old hypertensive male used fenofibrate to lower his triglyceride levels; however, the investigation revealed that it caused a significant increase in the desire and ingestion of greasy food items which caused fluctuating high blood pressure. Correction of the dietary regimen and a modification in the usual recommended drug dose led to a significant positive development of the medical case. Specifically, it was successful in adjusting the systolic and diastolic blood pressure components and blood test parameters, and was effective in correcting the glucose criteria back to the acceptable standard range.
Conclusion: This is the first evidence in the literature on a poorly controlled hypertension case associated indirectly with fenofibrate.
Development of EEG measurement and processing system in LabVIEW development environment
Authors: Barsy Bence Gergő , Győri Gyula , Szemes Péter Tamás 
Published: October 2020

AbstractOur research team has developed a system and methodology for measuring psycho-physiological parameters, which can be used to determine the level of fatigue and fitness of the person being measured. This article describes the electroencephalography (EEG) part of this system. This article covers the technical and mathematical background of EEG measurement, the selection and implementation of the measurement tool in the development environment, and the development of the measurement and processing algorithm. The result is a system that can detect, digitize, and process the digitized signal from the brain, and save the processed signal in an XML database.
The Handbook of Technology and Second Language Teaching and Learning, edited by Carol A. Chapelle and Shannon Sauro
Authors: Di Mauro-Jackson Moira 
Published: October 2020

The Handbook of Technology and Second Language Teaching and Learning Edited by Carol A. Chapelle and Shannon Sauro Hoboken, NJ: Wiley Blackwell US $195.00 ISBN 9781118914038 (Hardcover) 520 pages 2017
TUJUAN PEMIDANAAN DAN PERTIMBANGAN HAKIM DALAM MENJATUHKAN PIDANA TERHADA PENGGUNA SEKALIGUS PENGEDAR NARKOTIKA
Authors: Yakin Nabain 
Published: October 2020

Narkotika adalah masalah terbesar di negara Indonesia. Bisa dikatakan narkotika adalah musuh bersama. Penyalahgunaan narkotika di Indonesia semakin hari semakin meluas, tentu ini sangatlah mempengaruhi dan merusak generasi muda. Penegak hukum dan seluruh elemen masyarakat harus bersatu untuk memerangi masalah narkotika ini, karena kita tau bahwa dampak negative dari pemakaian narkotika ini sangat dahsyat, bukan hanya diri sendiri melainkan bangsa dan negara. Penegakan hukum terhadap pengguna sekaligus pengedar narkotika haruslah seberat mungkin, agar diharapkan bisa menekan maraknya penggunaan narkotika di masyarakat Indonesia, khususnya generasi muda.Jenis penelitian yang penulis gunakan adalah penelitian hukum normatif, bahan-bahan yang dapat dijadikan objek dalam penelitian normatif adalah bahan-bahan yang berupa primer, bahan sekunder, dan tersier. Penelitian yang penulis lakukan juga menggunakan system wawancara atau tanya jawab dengan Hakim Pengadilan Negeri Yogyakarta untuk mengumpulkan segala informasi tentang penelitian yang ditulis penelitti.Hasil penelitian yaitu Penjatuhan Sanksi Pidana terhadap Pelaku Pengguna sekaligus Pengedar Narkotika dalam perkara penyalahgunaan narkotika dengan Pertimbangan Hakim dalam Pemidanaan terhadap Pengguna sekaligus Pengedar Narkotika, tentunya dengan pertimbangan pedoman Perundang-Undangan Narkotika dan pertimbangan dakwaan yang di ajukan oleh jaksa penuntut umum. Narkotika saat ini sudah sangat meresahkan masyarakat Indonesia karena benda ini adalah benda yang apabila di konsumsi oleh penggunanya akan berdampak buruk. Kata kunci: Pemidanaan, Tindak Pidana Narkotika, Penegakan Hukum
Investigating the Role of Physical Activity on Pulmonary Function among Cement Factory Workers
Authors: Dashti khavidaki Mohammad Hassan , Ramezani Javad , Minaeifar Amir Abbas 
Published: October 2020

Introduction: Inhalation of suspended particulates in cement plants is one of the most important risk factors for pulmonary and respiratory problems for workers of these factories. The purpose of this study was to investigate the role of physical activity on pulmonary function among cement factory workers.
Method: This cross-sectional descriptive-analytical study was conducted among 82 cement factory workers. They were selected based on the available sampling method and volunteers were included in the study. According to Beck questionnaire, 48 people were categorized in the inactive and 34 in the active groups. Pulmonary function indices included VC, FVC, FEV1, FEV1, to FVC ratio. Furthermore, the forced expiratory flow of 25-75% (FEF 25-75%) and Spirometry were used to determine the pulmonary capacity of workers. Independent T-test was applied for comparing the two groups and SPSS software ver. 23 was run for data analysis.
Results: The results showed that VC, FEV1 / FVC, and FEF 25–75% indices in the active group were significantly higher than the inactive group (p /0,000) (p≥0.01) (p≥0.03). ). Moreover, FVC and FEV1 indices in the active group were not significantly different (p≥ 0.18) (p 14 0.14) from the inactive group.
Discussion: Our investigations showed the positive effect of physical activity and exercise on the pulmonary parameters and respiratory function of the cement factory workers. Therefore, these people are recommended to exercise regularly during the week to prevent respiratory and health problems caused by high concentrations of cement dust.
The Relationship between Social Support and General Health among Employees of Ceramic Tile Industry: A case study
Authors: Roozbeh Behzad , Pourmovahed Zahra , Roozbeh Mehdi 
Published: October 2020

Introduction: Workers' health is highly important since it affects a country’s industry. Social support plays an important role in employees’ health. The purpose of this study was to determine the relationship between social support and general health among employees of Yazd Ceram Tile Company in 2017.
Methods: In this cross-sectional study, 224 employees of Yazd Ceram Tile Company were selected using census sampling. Data collection instruments included demographic information questionnaire, Goldberg General Health Questionnaire (GHQ), and Social Support Appraisals (SS‐A) scale. Data were analyzed by SPSS 21 software using Mann-Whitney, Kruskal-Wallis, and Spearman correlation tests.
Results: Social support had an inverse relationship with all domains of general health. In other words, increased social support improved the employees’ general health. Social support had a significant relationship with the two dimensions of social dysfunction and depression (p<0.0001 and p= 0.028, respectively).
Conclusion: The factory staffs were at a relatively good level of social support, but they were close to the cut-off point considering their general health level. In general, higher levels of social support can lead to higher levels of general health in employees. This relationship is more important in terms of social functioning and depression (two dimensions of general health).
Investigation and Identification of Human Factors Related to Traffic Accidents leading to injury or Death in Yazd City
Authors: Tarfiei Azam , Ehrampoush Mohammad Hassan , lotfi Mohammad Hassan , Adamizadeh Ali Reza , Namayandeh Seyedeh Mahdieh , Ghaneian Mohammad Taghi 
Published: October 2020

Introduction: Traffic accidents are a major problem in the field of transportation in Iran. To address this problem, detailed studies are needed especially over the impact of human risk factors. Therefore, the present study was conducted with the aim of identifying and recognizing the human characteristics associated with the occurrence of traffic accidents resulting in injury or death in the city of Yazd.
Method: In this cross-sectional (descriptive-analytical) study, Yazd traffic accident data were collected using simple sampling method. The data were collected on the basis of COM form 114 by traffic experts present at the accident scenes. After data collection, the data were entered into SPSS software version 20 and analyzed using descriptive statistics, Chi-square, and Mann-Whitney tests.
Results: A total of 2082 cases were studied in traffic accidents (pedestrians=8.8%, passengers=15.4%, and drivers=75.8%). The average age of injured and deceased persons in traffic accidents were 35.08±13.89 and 45.37±17.12 years, respectively. The most common human factors involved in traffic accidents were rush and acceleration (96.8%). Moreover, nonconformity of priority right was 98.9%. A statistically significant relationship was found between human factors and traffic accidents leading to death or injury (p-value=0.04).
Conclusion: According to the findings, controlling human risk factors can reduce the risk of death and injuries in traffic accidents. Officials, policymakers, and planners can also plan on the most influential factor by carefully analyzing human errors in the event of a traffic accident.
SWOT analysis of BP. Tapera: A public housing savings implementing agency in Indonesia
Authors: Soeprapto Dedy Dewanto 
Published: October 2020

This study aims to implement a SWOT Analysis of the operationalization of BP. Tapera (Badan PelaksanaTabungan Perumahan Rakyat or translated in English as Public Housing Savings Implementing Agency), so that we can see the challenges the agency is facing in the future. The research method used is the external analysis and internal analysis of the strategic management model. Based on the results of SWOT analysis research, there are opportunities for high economic growth and a large population, while threats are requiring high Operational costs and IT investment costs, whilst the strengths are a culture of mutual cooperation and transparent information system, on the other hand, weaknesses have no branches and weak human resources. In conclusion, BP. Tapera must immediately formulate and implement strategies to respond to the SWOT analysis.
Motivation and retention of teachers in private secondary schools in Kenya
Authors: Kariuki Anne 
Published: October 2020

Employee retention has become a key focus of the human resource professional agenda. Organizations and schools have come to the conclusion that money could be saved by reducing employee turnover. However, studies have been inconclusive on motivating factors that lower employee retention. The main objective of this study was to determine the influence of motivation on the retention of employees in secondary schools in Kenya. Based on an exhaustive review of literature, three constructs of motivation were taken into consideration namely management. The major hypothesis of the study was that motivation significantly influences the retention of teachers in private secondary schools. To test the hypothesis, three sub-hypotheses were developed; compensation significantly influences employee retention; supervision significantly influences employee retention and psychological contract significantly influences employee retention. A mixed methodology approach was adopted and data was collected using a structured questionnaire and a structured interview guide. Descriptive statistics including frequencies, correlation analysis, and linear regression were applied to test the research hypotheses. The regression results indicate that motivation is causing a 7.0 percent variation in retention, implying a weak relationship. The weak relationship can be explained by poor salaries, authoritarian supervision, and breach of the psychological contract.
Uniqueness of psychological contract in a faith-based organization (FBO)
Authors: Handayani Erna , Tjahjono Heru Kurnianto , Darmawan Akhmad 
Published: October 2020

This study aims to explore the uniqueness of the psychological contract in the Faith-Based Organization (FBO). Psychological contracts, as part of the bond between individuals and organizations, are constantly evolving research. In line with the Conservation of Organizational Resources (COR) theory, organizations strive to defend their resources. Faith-Based Organization (FBO) is an organization with minimal written formal contracts. The bond with the members is a bond with the same values ??and goals. This research examines the psychological contract of FBO, from the aspects of formation, contribution, and violation. The formation of shared values ??which becomes the affective commitment of FBO members is specifically discussed because of the uniqueness of the organization with its ideological and religiosity sides. Using the lens of the COR theory, this study sees the psychological contract of the two elements of the FBO, namely members and organizations. This study is a literature review using traditional narrative methods. The results show that there have not been many in-depth studies of the psychological contract on religious organizations (FBO) with religious aspects that characterize the psychology of individuals in it. This study creates new gaps in research related to psychological contracts.