bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healthcare utilisation prior to suicide in persons with alcohol use disorder: national cohort and nested case–control study
Authors: Crump Casey , Edwards Alexis C. , Kendler Kenneth S. , Sundquist Jan , Sundquist Kristina 
Published: June 2020

BackgroundAlcohol use disorder (AUD) is common and associated with increased risk of suicide.AimsTo examine healthcare utilisation prior to suicide in persons with AUD in a large population-based cohort, which may reveal opportunities for prevention.MethodA national cohort study was conducted of 6 947 191 adults in Sweden in 2002, including 256 647 (3.7%) with AUD, with follow-up for suicide through 2015. A nested case–control design examined healthcare utilisation among people with AUD who died by suicide and 10:1 age- and gender-matched controls.ResultsIn 86.7 million person-years of follow-up, 15 662 (0.2%) persons died by suicide, including 2601 (1.0%) with AUD. Unadjusted and adjusted relative risks for suicide associated with AUD were 8.15 (95% CI 7.86–8.46) and 2.22 (95% CI 2.11–2.34). Of the people with AUD who died by suicide, 39.7% and 75.6% had a healthcare encounter <2 weeks or <3 months before the index date respectively, compared with 6.3% and 25.4% of controls (adjusted prevalence ratio (PR) and difference (PD), <2 weeks: PR = 3.86, 95% CI 3.50–4.25, PD = 26.4, 95% CI 24.2–28.6; <3 months: PR = 2.03, 95% CI 1.94–2.12, PD = 34.9, 95% CI 32.6–37.1). AUD accounted for more healthcare encounters within 2 weeks of suicide among men than women (P = 0.01). Of last encounters, 48.1% were in primary care and 28.9% were in specialty out-patient clinics, mostly for non-psychiatric diagnoses.ConclusionsSuicide among persons with AUD is often shortly preceded by healthcare encounters in primary care or specialty out-patient clinics. Encounters in these settings are important opportunities to identify active suicidality and intervene accordingly in patients with AUD.
Advanced Radiation Therapy Technology Use in the Treatment of Bone Metastases in a Public, Salary-Funded, Non-Incentivized Health Care System
Authors: Chan Matthew , Olson Robert , Lefresne Shilo , McKenzie Michael 
Published: June 2020

PURPOSE: There is limited evidence to support the routine use of conformal radiotherapy (RT) techniques in the treatment of bone metastases. This study evaluated trends in advanced technique use within the province of British Columbia. MATERIALS AND METHODS: Data on patients who received RT for bone metastases between 2009 and 2016 (with the exception of 2012) at 6 regional cancer centers were reviewed. Descriptive statistics summarized radiation technique patterns. Logistic regression assessed the influence of patient, treatment, and provider variables on receipt of RT technique. RESULTS: A total of 24,215 RT courses were identified; 97% were planned by simple RT and 3% by advanced techniques (3-dimensional conformal radiotherapy, intensity-modulated radiotherapy, and stereotactic body radiotherapy). The use of advanced techniques was significantly higher in recent years compared with in 2009 (odds ratios [ORs], 2.2, 4.2, 4.2, and 6.3, respectively, for the years 2013 to 2016; P < .001). Patients with thyroid, sarcoma, and neuroendocrine malignancies (ORs, 10.3, 5.5, and 5.2, respectively; P < .005) were more likely to be treated with advanced techniques, as were skull, sternum, rib, and pelvic metastases (ORs, 8.0, 5.2, 2.2, and 2.2, respectively; P < .001). Advanced techniques were most commonly used in the setting of re-irradiation (38%). They were associated with slightly higher incompletion rates (3.0% v 1.5%, P < .005) and less use within 30 days of death (6% v 15%, P < .001). CONCLUSION: Within our publicly funded, salary-based provincial health care system, we found that the majority of bone metastases are still being treated by simple RT; however, the use of advanced techniques is increasing, and we identified select patterns in which they are being prescribed. Additional study into clinical benefit is required.
Palbociclib in Patients With Non–Small-Cell Lung Cancer With CDKN2A Alterations: Results From the Targeted Agent and Profiling Utilization Registry Study
Authors: Ahn Eugene R. , Mangat Pam K. , Garrett-Mayer Elizabeth , Halabi Susan , Dib Elie G. , Haggstrom Daniel E. , Alguire Kathryn B. , Calfa Carmen J. , Cannon Timothy L. , Crilley Pamela A. , Gaba Anu G. , Marr Alissa S. , Sangal Ashish , Thota Ramya , Antonelli Kaitlyn R. , Islam Samiha , Rygiel Andrew L. , Bruinooge Suanna S. , Schilsky Richard L. 
Published: June 2020

PURPOSE The Targeted Agent and Profiling Utilization Registry (TAPUR) Study is a phase II pragmatic basket trial evaluating antitumor activity of commercially available targeted agents in patients with advanced cancer with genomic alterations known to be drug targets. Results in a cohort of patients with non–small-cell lung cancer (NSCLC) with CDKN2A alterations treated with palbociclib are reported. METHODS Eligible patients were ≥ 18 years old with advanced NSCLC, no remaining standard treatment options, measurable disease, Eastern Cooperative Oncology Group performance status of 0 to 2, and adequate organ function. Patients with NSCLC with CDKN2A alterations and no Rb mutations received palbociclib 125 mg orally once daily for 21 days, followed by 7 days off. Simon’s two-stage design was used with a primary study end point of objective response or stable disease (SD) of at least 16 weeks in duration. Secondary end points are progression-free survival (PFS), overall survival (OS), and safety. RESULTS Twenty-nine patients were enrolled from January 2017 to June 2018; two patients were not evaluable for response but were included in safety analyses. One patient with partial response and six patients with SD were observed, for a disease control rate of 31% (90% CI, 19% to 40%). Median PFS was 8.1 weeks (95% CI, 7.1 to 16.0 weeks), and median OS was 21.6 weeks (95% CI, 14.1 to 41.1 weeks). Eleven patients had at least 1 grade 3 or 4 adverse event (AE) or serious AE (SAE) possibly related to palbociclib (most common, cytopenias). Other AEs or SAEs possibly related to the treatment included anorexia, fatigue, febrile neutropenia, hypophosphatemia, sepsis, and vomiting. CONCLUSION Palbociclib monotherapy demonstrated evidence of modest antitumor activity in heavily pretreated patients with NSCLC with CDKN2A alterations. Additional investigation is necessary to confirm efficacy and utility of palbociclib in this population.
A Dispute over Patrimonial Property in Huaquechula, Mexico: The Chimalhua Case, 1738–1740
Authors: Mysyk Avis , Martínez Edgar de Ita 
Published: June 2020

AbstractThroughout the colonial period, disputes over the inheritance of property were common among indigenous peoples, both nobles and commoners. From the outset, they became familiar with and adept at negotiating their interests from within the colonial legal system. Based on the corresponding archival document and map, this article explores how the Chimalhuas used this system to resolve an intrafamilial dispute over patrimonial property. The dispute was not one between equals but, because the Spanish legal system was flexible, its legal decisions arbitrary, both sides attempted to use late-colonial modes of argumentation, legal strategies, and status- and class-based rhetoric to their advantage. This article also considers how the wider context of indigenous population recovery and Spanish pressure on resources within which the dispute occurred had implications for two separate but related issues. First, the status of the Chimalhuas had declined and, second, the dispute was largely confined to the negotiation of individual interests.
Carceral Entanglement in the Work of Leila Abdelrazaq
Authors: Feldman Keith P. 
Published: June 2020

Abstract
This essay considers how the graphic arts of Leila Abdelrazaq give form to Palestine’s contemporary worldliness and to the worldliness of Palestinian difference. It argues that Abdelrazaq’s work illustrates the entanglement of diaspora, memory, and futurity within the interconnected structures of enclosure and expulsion.
Indefinite Detention
Authors: Butler Judith 
Published: June 2020

Abstract
Indefinite detention is a legal norm and practice that is increasingly acceptable throughout the world. It consists of arrest and forcible detention without a clear communication of crimes committed, and it can last indefinitely, since it deprives the detained of recourse to courts for review and release. Kafka’s Trial, which brought this kind of legal nightmare into focus, proves relevant for understanding the temporal sequence by which the expectation of justice through law is confounded and negated. Over and against the expectation that a set of legal procedures sequentially followed will deliver a fair verdict, if not justice, Kafka’s reordering of space and time exposes a world in which the allegation becomes punishment and the expected release becomes the renewal of detention itself. The relation between fictional and legal sequence proves salient for understanding the indefinite postponement of justice through law, exposing in the end a form of legal violence indistinguishable from criminality.
Critical (Dis)pleasure
Authors: Penteado Bruno 
Published: June 2020

AbstractRecent developments in literary studies that can be grouped under the umbrella term postcritique purport to restore, in our disciplinary practices, attention to affect, pleasure, and attachment, which postcritics believe the critical tradition has silenced and neglected. Postcritics depict critique as a violent hermeneutic practice of excavating a text’s hidden truths. This essay claims that postcritique’s understanding of critical theory is misguided and caricatural. By focusing on key thinkers of the critical tradition, particularly French philosophers, it argues that hermeneutic openness and nonmastery is a constant in many critical writings—and so is the question of pleasure. It suggests that many of postcritique’s propositions, which postcritics affirm are innovative and claim critique has disavowed, have always been a recurring topic in the work of critical theorists.
Blanchot and Lautréamont
Authors: Allen William S. 
Published: June 2020

Abstract
Blanchot’s readings of Lautréamont are among the most important writings on this challenging author, and they are also crucial for the development of his own thinking, but they have never been discussed in depth. This essay surveys the whole range of Blanchot’s writings on Lautréamont and shows how they constitute the first considered attempt within his thinking to examine the notions of the fantastic and the image in relation to the experience of metaphor. This survey not only enables a renewed understanding of the significance of Lautréamont’s writings but also reveals how Blanchot transforms the Hegelian thinking of experience by way of its passage through literature.
Cortical distribution of GABAergic interneurons is determined by migration time and brain size
Authors: Fazzari Pietro , Mortimer Niall , Yabut Odessa , Vogt Daniel , Pla Ramon 
Published: June 2020

ABSTRACT
Cortical interneurons (CINs) originate in the ganglionic eminences (GEs) and migrate tangentially to the cortex guided by different attractive and repulsive cues. Once inside the cortex, the cellular and molecular mechanisms determining the migration of CINs along the rostrocaudal axis are less well understood. Here, we investigated the cortical distribution of CINs originating in the medial and caudal GEs at different time points. Using molecular and genetic labeling, we showed that, in the mouse, early- and late-born CINs (E12 versus E15) are differentially distributed along the rostrocaudal axis. Specifically, late-born CINs are preferentially enriched in cortical areas closer to their respective sites of origin in the medial or caudal GE. Surprisingly, our in vitro experiments failed to show a preferential migration pattern along the rostrocaudal axis for medial- or caudal-born CINs. Moreover, in utero transplantation experiments suggested that the rostrocaudal dispersion of CINs depends on the developmental stage of the host brain and is limited by the migration time and the increasing size of the developing brain. These data suggest that the embryonic expansion of the cortex contributes to the rostrocaudal distribution of CINs.
C-terminal phosphorylation modulates ERM-1 localization and dynamics to control cortical actin organization and support lumen formation during Caenorhabditis elegans development
Authors: Ramalho João J. , Sepers Jorian J. , Nicolle Ophélie , Schmidt Ruben , Cravo Janine , Michaux Grégoire , Boxem Mike 
Published: June 2020

ABSTRACT
ERM proteins are conserved regulators of cortical membrane specialization that function as membrane-actin linkers and molecular hubs. The activity of ERM proteins requires a conformational switch from an inactive cytoplasmic form into an active membrane- and actin-bound form, which is thought to be mediated by sequential PIP2 binding and phosphorylation of a conserved C-terminal threonine residue. Here, we use the single Caenorhabditis elegans ERM ortholog, ERM-1, to study the contribution of these regulatory events to ERM activity and tissue formation in vivo. Using CRISPR/Cas9-generated erm-1 mutant alleles, we demonstrate that a PIP2-binding site is crucially required for ERM-1 function. By contrast, dynamic regulation of C-terminal T544 phosphorylation is not essential but modulates ERM-1 apical localization and dynamics in a tissue-specific manner, to control cortical actin organization and support lumen formation in epithelial tubes. Our work highlights the dynamic nature of ERM protein regulation during tissue morphogenesis and the importance of C-terminal phosphorylation in fine-tuning ERM activity in a tissue-specific context.
Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia
Authors: Fil Daniel , Chacko Balu K. , Conley Robbie , Ouyang Xiaosen , Zhang Jianhua , Darley-Usmar Victor M. , Zuberi Aamir R. , Lutz Cathleen M. , Napierala Marek , Napierala Jill S. 
Published: June 2020

ABSTRACT
Friedreich's ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by reduced expression of the mitochondrial protein frataxin (FXN). Most FRDA patients are homozygous for large expansions of GAA repeat sequences in intron 1 of FXN, whereas a fraction of patients are compound heterozygotes, with a missense or nonsense mutation in one FXN allele and expanded GAAs in the other. A prevalent missense mutation among FRDA patients changes a glycine at position 130 to valine (G130V). Herein, we report generation of the first mouse model harboring an Fxn point mutation. Changing the evolutionarily conserved glycine 127 in mouse Fxn to valine results in a failure-to-thrive phenotype in homozygous animals and a substantially reduced number of offspring. Like G130V in FRDA, the G127V mutation results in a dramatic decrease of Fxn protein without affecting transcript synthesis or splicing. FxnG127V mouse embryonic fibroblasts exhibit significantly reduced proliferation and increased cell senescence. These defects are evident in early passage cells and are exacerbated at later passages. Furthermore, increased frequency of mitochondrial DNA lesions and fragmentation are accompanied by marked amplification of mitochondrial DNA in FxnG127V cells. Bioenergetics analyses demonstrate higher sensitivity and reduced cellular respiration of FxnG127V cells upon alteration of fatty acid availability. Importantly, substitution of FxnWT with FxnG127V is compatible with life, and cellular proliferation defects can be rescued by mitigation of oxidative stress via hypoxia or induction of the NRF2 pathway. We propose FxnG127V cells as a simple and robust model for testing therapeutic approaches for FRDA.
Rabbit model of Staphylococcus aureus implant-associated spinal infection
Authors: Gordon Oren , Miller Robert J. , Thompson John M. , Ordonez Alvaro A. , Klunk Mariah H. , Dikeman Dustin A. , Joyce Daniel P. , Ruiz-Bedoya Camilo A. , Miller Lloyd S. , Jain Sanjay K. 
Published: June 2020

ABSTRACT
Post-surgical implant-associated spinal infection is a devastating complication commonly caused by Staphylococcus aureus. Biofilm formation is thought to reduce penetration of antibiotics and immune cells, contributing to chronic and difficult-to-treat infections. A rabbit model of a posterior-approach spinal surgery was created, in which bilateral titanium pedicle screws were interconnected by a plate at the level of lumbar vertebra L6 and inoculated with a methicillin-resistant S. aureus (MRSA) bioluminescent strain. In vivo whole-animal bioluminescence imaging (BLI) and ex vivo bacterial cultures demonstrated a peak in bacterial burden by day 14, when wound dehiscence occurred. Structures suggestive of biofilm, visualized by scanning electron microscopy, were evident up to 56 days following infection. Infection-induced inflammation and bone remodeling were also monitored using 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and computed tomography (CT). PET imaging signals were noted in the soft tissue and bone surrounding the implanted materials. CT imaging demonstrated marked bone remodeling and a decrease in dense bone at the infection sites. This rabbit model of implant-associated spinal infection provides a valuable preclinical in vivo approach to investigate the pathogenesis of implant-associated spinal infections and to evaluate novel therapeutics.
Photoperiodic induction without light-mediated circadian entrainment in a high arctic resident bird
Authors: Appenroth Daniel , Melum Vebjørn J. , West Alexander C. , Dardente Hugues , Hazlerigg David G. , Wagner Gabriela C. 
Published: June 2020

Organisms use changes in photoperiod to anticipate and exploit favourable conditions in a seasonal environment. While species living at temperate latitudes receive day length information as a year-round input, species living in the Arctic may spend as much as two-thirds of the year without experiencing dawn or dusk. This suggests that specialised mechanisms may be required to maintain seasonal synchrony in polar regions.Svalbard ptarmigan (Lagopus muta hyperborea) are resident at 74-81° north latitude. They spend winter in constant darkness (DD) and summer in constant light (LL); extreme photoperiodic conditions under which they do not display overt circadian rhythms.Here we explored how arctic adaptation in circadian biology affects photoperiodic time measurement in captive Svalbard ptarmigan. For this purpose, DD-adapted birds, showing no circadian behaviour, either remained in prolonged DD, were transferred into a simulated natural photoperiod (SNP) or were transferred directly into LL. Birds transferred from DD to LL exhibited a strong photoperiodic response in terms of activation of the hypothalamic thyrotropin-mediated photoperiodic response pathway. This was assayed through expression of the Eya3, Tshβ and deiodinase genes, as well as gonadal development. While transfer to SNP established synchronous diurnal activity patterns, activity in birds transferred from DD to LL showed no evidence of circadian rhythmicity.These data show that the Svalbard ptarmigan does not require circadian entrainment to develop a photoperiodic response involving conserved molecular elements found in temperate species. Further studies are required to define how exactly arctic adaptation modifies seasonal timer mechanisms.
Functional effect of vaterite – the presence of an alternative crystalline structure in otoliths alters escape kinematics of the brown trout
Authors: Vignon Matthias , Aymes Jean-Christophe 
Published: June 2020

ABSTRACT
The fast-start escape response is the main locomotor behaviour observed in fish to evade predatory attacks and thereby increase their probability of survival. Thus far, this high-speed sensory motor control has been extensively studied in relation to extrinsic factors. In contrast, there has been surprisingly little consideration of intrinsic individual factors that can mediate sensorial perception, such as inter-individual variability in mechanosensory systems. The inner ear of teleost fishes is composed of otoliths that play an important role in hearing and balance functions. While sagittal otoliths are normally composed of aragonite in many fish species, the inclusion of vaterite (an abnormal crystalline structure) has been reported in a number of individuals from different environments. There is currently strong theoretical and empirical evidence that vaterite deposition has a negative impact on auditory sensitivity in fishes. While the functional/behavioural implications of this defect on otolith-related hearing function has been hypothesised, it has remained largely untested experimentally. Here, using juvenile (0+ years) Salmo trutta originating from the wild in experimental conditions, we report for the first time that the deposition of calcium carbonate in its crystalline vateritic polymorph has significant pervasive effects on the escape kinematics of fish. The presence of an alternative crystalline structure in otoliths is likely to alter fish behaviour in ways that decrease survival. We also report that altered behaviour in individuals with vateritic otoliths is partially compensated for by the presence of a functional lateral line. Such functional compensation suggests more slight consequences, if any, in the wild.
Predictors for Survival in an International Cohort of Patients Undergoing Distal Pancreatectomy for Pancreatic Ductal Adenocarcinoma
Authors: Korrel M. , Lof S. , van Hilst J. , Alseidi A. , Boggi U. , Busch O. R. , van Dieren S. , Edwin B. , Fuks D. , Hackert T. , Keck T. , Khatkov I. , Malleo G. , Poves I. , Sahakyan M. A. , Bassi C. , Abu Hilal M. , Besselink M. G. ,   for the European Consortium on Minimally Invasive Pancreatic Surgery (E-MIPS)
Published: June 2020

Abstract
Background
Surgical factors, including resection of Gerota’s fascia, R0-resection, and lymph node yield, may be associated with survival after distal pancreatectomy (DP) for pancreatic ductal adenocarcinoma (PDAC), but evidence from large multicenter studies is lacking. This study aimed to identify predictors for overall survival after DP for PDAC, especially those related to surgical technique.

Patients and Methods
Data from an international retrospective cohort including patients from 11 European countries and the USA who underwent DP for PDAC (2007–2015) were analyzed. Cox proportional hazard analyses were performed and included Gerota’s fascia resection, R0 resection, lymph node ratio, extended resection, and a minimally invasive approach.

Results
Overall, 1200 patients from 34 centers with median follow-up of 15 months [interquartile range (IQR) 5–31 months] and median survival period of 30 months [95% confidence interval (CI), 27–33 months] were included. Gerota’s fascia resection [hazard ratio (HR) 0.74; p = 0.019], R0 resection (HR 0.70; p = 0.006), and decreased lymph node ratio (HR 0.28; p < 0.001) were associated with improved overall survival, whereas extended resection (HR 1.75; p < 0.001) was associated with worse overall survival. A minimally invasive approach did not improve survival as compared with an open approach (HR 1.14; p = 0.350). Adjuvant chemotherapy (HR 0.67; p = 0.003) was also associated with improved overall survival.

Conclusions
This international cohort identified Gerota’s fascia resection, R0 resection, and decreased lymph node ratio as factors associated with improved overall survival during DP for PDAC. Surgeons should strive for R0 resection and adequate lymphadenectomy and could also consider Gerota’s fascia resection in their routine surgical approach.