bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatiotemporal gait characteristics and ankle kinematics of backward walking in people with chronic ankle instability
Authors: Balasukumaran Tharani , Gottlieb Uri , Springer Shmuel 
Published: July 2020

AbstractBackward walking offers a unique challenge to balance and ambulation. This study investigated the characteristics of spatiotemporal gait factors and ankle kinematics during backward walking in people with chronic ankle instability. Sixteen subjects with chronic ankle instability and 16 able-bodied controls walked on a treadmill at their self-selected speed under backward and forward walking conditions. Gait speed, cadence, double limb support percentage, stride time variability, and three-dimensional ankle kinematics were compared between groups and conditions. During backward walking, both groups had significantly slower gait speed, lower cadence, and greater stride time variability. In addition, under backward walking condition, subjects in both groups demonstrated significant sagittal and frontal kinematic alternations, such as greater dorsiflexion and inversion following initial contact (0–27.7%, 0–25.0% of gait cycle respectively, p < 0.001). However, there were no significant differences between groups in any of the measured outcomes. This indicates that subjects with chronic ankle instability adapt to self-selected speed backward walking similarly to healthy controls. Assessments with more challenging tasks, such as backward walking with dual task and backward walking at fast speed, may be more appropriate for testing gait impairments related to chronic ankle instability.
Velocity and acceleration freely tunable straight-line propagation light bullet
Authors: Li Zhaoyang , Kawanaka Junji 
Published: July 2020

AbstractThree-dimensional (3-D) light solitons in space–time, referred to as light bullets, have many novel properties and wide applications. Here we theoretically show how the combination of diffraction-free beam and ultrashort pulse spatiotemporal-coupling enables the creation of a straight-line propagation light bullet with freely tunable velocity and acceleration. This light bullet could propagate with a constant superluminal or subluminal velocity, and it could also counter-propagate with a very fast superluminal velocity (e.g., − 35.6c). Apart from uniform motion, an acceleration or deceleration straight-line propagation light bullet with a tunable instantaneous acceleration could also be produced. The high controllability of the velocity and the acceleration of a straight-line propagation light bullet would enable very specific applications, such as velocity and/or acceleration matched micromanipulation, microscopy, particle acceleration, radiation generation, and so on.
Solar-trackable super-wicking black metal panel for photothermal water sanitation
Authors: Singh Subhash C. , ElKabbash Mohamed , Li Zilong , Li Xiaohan , Regmi Bhabesh , Madsen Matthew , Jalil Sohail A. , Zhan Zhibing , Zhang Jihua , Guo Chunlei 
Published: July 2020

AbstractSolar-based water sanitation is an environmentally friendly process for obtaining clean water that requires efficient light-to-heat-to-vapour generation. Solar-driven interfacial evaporation has potential, but the inability to control interfacial evaporators for solar tracking limits efficiency at large solar zenith angles and when using optical concentration. Furthermore, clogging affects the efficiency of the device. Here, we create a super-wicking and super-light-absorbing (SWSA) aluminium surface for efficient solar-based water sanitation. The measured evaporation rate exceeds that of an ideal device operating at 100% efficiency, which we hypothesize resulted from a reduced enthalpy of vaporization within the microcapillaries. Limited solar absorber–water contact for water transport minimizes heat losses to bulk water and maximizes heat localization at the SWSA surface. The device can be mounted at any angle on a floating platform to optimize incident solar irradiance and can readily be integrated with commercial solar-thermal systems. With a design that is analogous to bifacial photovoltaic solar panels, we show a 150% increase in efficiency compared with a single-sided SWSA. Given the open capillary channels, the device surface can be easily cleaned and reused. Using the SWSA surface to purify contaminated water, we show a decrease in the level of contaminants to well below the WHO and EPA standards for drinkable water.
Multiple Co-Occurring Vestibular Disorders Identified Using the Dizziness Symptom Profile
Authors: Roberts Richard A. , Jacobson Gary P. , Hatton Kelsey 
Published: July 2020

Purpose
The purpose of the current investigation was to determine the interrelations among vestibular disorders from a data set generated from the patient perspective as compared to previous data generated from the physician's perspective.

Method

The data for the current investigation originated from a previously published study describing the development of the Dizziness Symptom Profile (DSP; Jacobson et al.,
2019
). The DSP is a 31-item patient self-report tool designed to help primary care physicians in the development of a differential diagnosis using the patient's level of agreement with each dizziness and symptom-related statement. Responses to these items converge on common vestibular diagnoses and were previously found to agree with ear specialist differential diagnoses 70.3% of the time. Data were collected for 131 subjects (
M
age
= 56.7 years, 72 women) seen for evaluation in a tertiary dizziness specialty clinic. For this study, the data were analyzed using descriptive statistics to determine the frequency of single diagnoses, multiple diagnoses, co-occurring diagnoses, and patterns of co-occurrence.

Results
Results indicated that 52.7% of patients endorsed a single vestibular diagnosis and 47.3% endorsed two or more vestibular diagnoses. Benign paroxysmal positional vertigo (BPPV) and vestibular migraine were the most common single diagnoses and also the most common co-occurring diagnoses. As the number of diagnoses endorsed on the DSP increased, so did the percentage of time that BPPV and vestibular migraine would occur.

Conclusions
Results support and extend the work of others but using data generated from the perspective of the patient. A slight majority of patients endorsed a single disorder, but almost as many patients endorsed more than one vestibular diagnosis. BPPV and vestibular migraine were the most common single vestibular diagnoses and also the most common co-occurring vestibular diagnoses; vestibular migraine was more common when multiple diagnoses were endorsed. Results suggest it is common for patients to volunteer symptoms that cannot be explained by a single vestibular diagnosis. This finding is in agreement with physician-generated diagnosis data. Clinicians should consider the possibility of co-occurring diagnoses in complicated patients or in patients who are not responding optimally to management of a single vestibular disorder. The DSP is a tool that encourages clinicians to consider multiple co-occurring vestibular disorders as the source of patient complaints.
Nierenzysten und zystische Nierenerkrankungen bei Kindern (AWMF S2k-Leitlinie)
Authors: Gimpel Charlotte , Bergmann Carsten , Brinkert Florian , Cetiner Metin , Gembruch Ulrich , Haffner Dieter , Kemper Markus , König Jens , Liebau Max , Maier Rolf Felix , Oh Jun , Pape Lars , Riechardt Silke , Rolle Udo , Rossi Rainer , Stegmann Joachim , Vester Udo , Kaisenberg Constantin von , Weber Stefanie , Schaefer Franz 
Published: July 2020

ZusammenfassungDie Leitlinie wurde im Konsens aller relevanten deutschen Fachgesellschaften zusammen mit Patientenvertretern erstellt. Standard der prä- und postnatalen Bildgebung von Nierenzysten ist die Sonografie, die auch im Abdomen und inneren Genitale extrarenale Manifestationen ausschließen soll. Die MRT hat einzelne Indikationen. Bei Verdacht auf zystische Nierenerkrankungen ist eine kindernephrologische Vorstellung indiziert. Die pränatale Betreuung muss auf sehr unterschiedliche Schweregrade zugeschnitten werden. Bei renalem Oligohydramnion wird eine Entbindung in einem Perinatalzentrum der höchsten Stufe empfohlen. Neugeborenen sollte eine Nierenersatztherapie nicht allein aufgrund des Alters vorenthalten werden. Bei unilateraler multizystischer Nierendysplasie ist keine funktionelle Bildgebung oder Nephrektomie notwendig, aber (wie auch bei uni- oder bilateraler Nierenhypo-/dysplasie mit Zysten) eine langfristige nephrologische Überwachung. Bei der ARPKD (autosomal rezessive polyzystische Nierenerkrankung), Nephronophthise, Bardet-Biedl-Syndrom und HNF1B-Mutationen müssen extrarenale Manifestationen beachtet werden; eine genetische Testung ist hier sinnvoll. Kinder mit tuberöser Sklerose, Tumorprädispositionen (z. B. von Hippel Lindau Syndrom) oder hohem Risiko für erworbene Nierenzysten sollten regelmäßige Nierensonografien erhalten. Auch asymptomatische Kinder von Eltern mit ADPKD (aut. dominanter polyzystischer Nierenerkrankung) sollten regelmäßig auf Hypertonie und Proteinurie untersucht werden. Eine präsymptomatische sonografische oder genetische Diagnostik dieser Minderjährigen sollte nur nach ausführlicher Aufklärung erwogen werden. Einfache (isolierte) Zysten sind bei Kindern sehr selten und eine ADPKD eines Elternteils sollte ausgeschlossen sein. Komplexe Nierenzysten bedürfen weiterer Abklärung.
Qualität der psychiatrischen (Krankenhaus-)Versorgung – Perspektiven?
Authors: Kunze Heinrich , Schepker Renate 
Published: July 2020

ZusammenfassungDeutschland hat eine vergleichsweise gute Versorgungsqualität für bestimmte Patientengruppen und gehört bezüglich der Ausgaben zur Spitze Europas. Die Differenzierung des Versorgungssystems seit der Psychiatrie-Enquete war mit einer zunehmenden Fragmentierung der Angebote verbunden. Diese Zergliederung trägt zur Fragmentierung der Beziehungen der Patienten zu ihren Behandlern und zum sozialen Umfeld bei. Das Aufnahmemanagement in Kliniken erscheint weiterhin verbesserungswürdig. Sektorenübergreifende Behandlungsformen sind im Ausland und modellhaft erprobt worden und sollten als Vorbild für politisches Handeln im Versorgungssystem konsequent genutzt werden.Mit den vorhandenen Ressourcen könnten bessere und wirtschaftlichere Behandlungsergebnisse erreicht werden. Das ist für die Zukunft einerseits wegen der zunehmenden Inanspruchnahme von Behandlung bei psychischen Störungen, andererseits zur Sicherung der Qualität bei chronisch und schwer psychiatrisch Erkrankten von großer Bedeutung.
RNA Sequencing of Formalin-Fixed and Paraffin-Embedded Tissue as a Complementary Method in Ophthalmopathology
Authors: Schlunck Günther , Boneva Stefaniya , Wolf Julian , Schlecht Anja , Reinhard Thomas , Auw-Hädrich Claudia , Lange Clemens 
Published: July 2020

AbstractThe high-throughput method of “Next Generation Sequencing” (NGS) allows cost-effective decoding of the nucleotide sequences of millions of RNA molecules in a sample. This makes it possible to determine the number of distinct RNA molecules in tissues or cells and to use these data to draw conclusions. The entirety of RNAs, in particular mRNAs (messenger RNAs) as potential precursors of proteins, provides a comprehensive insight into the functional state of the cells and tissues under investigation. In addition to cell cultures or unfixed tissue, formalin-fixed and paraffin-embedded (FFPE) tissue can also be analysed for this purpose using specific methods. In this overview, the methodological strategy and its application to the field of ophthalmic histopathology are presented.
Makuladegeneration – Das Auge isst mit
Authors: Friedrichsen Hans-Peter , Gröber Uwe 
Published: July 2020

ZusammenfassungDie altersbedingte Makuladegeneration (AMD) betrifft mittlerweile jeden 3. Deutschen über 60 Jahre. Das Alter, genetische Faktoren, starke UV-Exposition und Rauchen sind wichtige Risikofaktoren. Wesentliche Pathomechanismen der AMD sind oxidativer Stress, Inflammation und mitochondriale Dysfunktion. Da Therapiemöglichkeiten begrenzt sind, hat die Prävention einen hohen Stellenwert. Verschiedene Studien belegen positive Wirkungen bspw. von Glutathion, Ubiquinon/Ubiquinol, α-Liponsäure, Lutein, Zeaxanthin, Astaxanthin und Curcumin sowie von Vitaminen, ω-3-Fettsäuren, Spurenelementen und sekundären Pflanzenstoffen. Für den erfolgreichen Einsatz ist eine sinnvolle Kombination und Dosierung ausschlaggebend.
Mikronährstoffversorgung im Leistungssport
Authors: Erpenbach Klaus , Mayer Wolfgang , Hoffmann Uwe , Mücke Stefan 
Published: July 2020

ZusammenfassungDie vorgestellte Studie zeigt bei Leistungssportlern auf breiter Basis eine grenzwertige oder unzureichende Versorgung mit Mikronährstoffen. Mit Ausnahme von Folsäure und Vitamin B12 sind jugendliche Sportler dabei stets signifikant schlechter versorgt als die erwachsenen Athleten. Als ursächliche Faktoren werden v. a. der erhöhte Bedarf im Wachstum sowie eine kohlenhydratbetonte Ernährung der Jugendlichen diskutiert. Die durchschnittlich bessere Versorgung von A-Nationalspielern wird auf eine vom Verband gesteuerte Nährstoffsupplementierung zurückgeführt. Die Versorgung insb. mit Vitamin D, aber auch mit Coenzym Q10 und Vitamin B1 korreliert mit der Häufigkeit muskulärer Verletzungen, unter denen 73 % der untersuchten Spitzensportler leiden. Ein Zusammenhang zwischen der Nährstoffversorgung und den Parametern Infektanfälligkeit, Müdigkeit und Schlafstörungen war weniger deutlich bzw. nicht feststellbar.
Pilotstudie zum Hörscreening mit dem Mini-Audio-Test (MAT)
Authors: Löhler Jan , Schönweiler Rainer , Schlattmann Peter 
Published: July 2020

Zusammenfassung
Hintergrund Es gibt Hinweise, dass eine unbehandelte Schwerhörigkeit in der 2. Lebenshälfte das Risiko, an einer Demenz oder Depression zu erkranken, einen kognitiven Leistungsverlust zu erleiden, zu stürzen oder allgemein hilfsbedürftig zu werden, erhöht. Ein Großteil der Betroffenen ist nicht adäquat, z. B. mit Hörgeräten, behandelt. Der Mini-Audio-Test (MAT) ist ein evaluierter Fragebogen, der eine bisher nicht bekannte Schwerhörigkeit aufdecken kann. Mit dieser Studie sollte die Einsatzfähigkeit des MAT in einer repräsentativen Stichprobe der erwachsenen Bevölkerung getestet werden.
Methoden Im Frühjahr 2019 wurden insgesamt 123 Personen im Rahmen einer repräsentativen Befragung u. a. zu ihrem Hörvermögen mittels MAT befragt. Probanden mit auffälligem MAT wurde empfohlen, sich bei einem HNO-Arzt untersuchen zu lassen. Die zugehörigen Daten wurden anonymisiert zentral erfasst und deskriptiv statistisch ausgewertet.
Ergebnisse Insgesamt waren 79 der angesprochenen Probanden im Alter von 28 bis 93 Jahren bereit, an der Befragung teilzunehmen. Von diesen haben 63 den MAT ausgefüllt, 22 davon waren bereit, sich HNO-ärztlich untersuchen zu lassen; dieses ist nur in einem Fall tatsächlich geschehen.
Diskussion Ein unspezifischer Einsatz des MAT zum Screening auf Schwerhörigkeit erscheint zum jetzigen Zeitpunkt wenig Erfolg versprechend. Sinnvoller erscheint der strukturierte Einsatz, z. B. im Rahmen eines regulären Arztbesuchs ab dem 50. Lebensjahr. Ferner sollte die Bevölkerung grundsätzlich besser über die Risiken einer unbehandelten Schwerhörigkeit aufgeklärt werden.
Snare-tip soft coagulation is effective and efficient as a first-line modality for treating intraprocedural bleeding during Barrett’s mucosectomy
Authors: Vosko Sergei , Gupta Sunil , Shahidi Neal , Hourigan Luke F. , van Hattem W. Arnout , Bar-Yishay Iddo , Schoeman Scott , Sidhu Mayenaaz , Burgess Nicholas G. , Lee Eric Y. T. , Bourke Michael J. 
Published: July 2020

Background Intraprocedural bleeding (IPB) during multiband mucosectomy (MBM) for Barrett’s neoplasia can obscure the endoscopic field. Current hemostatic devices may affect procedure continuity and technical success. Snare-tip soft coagulation (STSC) as a first-line therapy for primary hemostasis has not previously been studied in this setting.
Methods Between January 2014 and November 2019, 191 consecutive patients underwent 292 MBM procedures for Barrett’s neoplasia within a prospective observational cohort in two tertiary care centers. A standard MBM technique was performed. IPB was defined as bleeding obscuring the endoscopic field that required intervention. The primary outcome was the technical success and efficacy of STSC.
Results IPB occurred in 63 MBM procedures (21.6 %; 95 % confidence interval 17.3 % – 26.7 %). STSC was attempted as first-line therapy in 51 IPBs, with the remainder requiring alternate therapies because of pooling of blood. STSC achieved hemostasis in 48 cases (94.1 % by per-protocol analysis; 76.2 % by intention-to-treat analysis). No apparatus disassembly was required to perform STSC.
Conclusions STSC is a safe, effective, and efficient first-line hemostatic modality for IPB during MBM for Barrett’s neoplasia.
Modified Partial Lateral Facetectomy of the Patella for Stage III Patellofemoral Osteoarthritis with 5-Year Follow-Up
Authors: Wang Mingjun , Li Xiaofeng , Li Peng , Wang Hongyan , Gao Wenxiang 
Published: July 2020

AbstractThe main aim of this article was to examine the therapeutic evaluation of our modified partial lateral facetectomy of the patella for stage III lateral patellofemoral osteoarthritis (PFOA), which includes (1) partial lateral patella articular facet that was resected; (2) coronal Z-shaped incision to lengthen lateral retinaculum; (3) patellar perimeter electrocoagulation to denervate. Between December 2008 and January 2013, 36 knees of 32 patients with severe patellofemoral (PF) osteoarthritis (OA) were treated with our modified partial patellar lateral facetectomy. All patients were stage III according to the Iwano scale, and their patellas were all Wiberg type III or Baumgartl type IV in shape. The study group included 6 males and 26 females with an average age of 54.03 years and an average disease course of 8.67 years. The modified Kujala scores were used to evaluate PF function, and the congruence angle was used to evaluate the patellar position. Knee Society Scores (KSS) were used to evaluate overall knee function. Six knees of five cases were lost to follow-up. Thirty knees of 27 cases were followed up for 5 years, with an average follow-up time of 60 ± 3.2 months. The average preoperative modified Kujala score was 15.93, and the average score at last follow-up was 32.03; The satisfactory PF function was achieved in 28 knees (93.33%). The congruence angle improved from preoperative +23. 07 degrees to 11. 91 degrees at the last follow-up. The average preoperative KSS were 110.40 points, which increased to 156.77 points at the last postoperative follow-up. Pain was significantly relieved, and the ability to climb stairs was significantly improved. All scores showed statistically significant improvements after surgery (p < 0.05). No complications were reported. Our modified partial lateral facetectomy of the patella for stage III lateral PFOA can relieve pain and partially improve function. This modified procedure is relatively simple, safe, and an effective treatment method for middle-aged and elderly patients with PFOA. Furthermore, this surgery can be used as an alternative or prephase to total knee arthroplasty. This is a Level IV, therapeutic study.
Detection and Measurement of Intracranial Aneurysm Compared between Magnetic Resonance Intracranial Black Blood Vessel Imaging and Gold Standard Cerebral Digital Subtraction Angiography
Authors: Songsaeng Dittapong , Sakarunchai Ittichai , Mongkolnaowarat Sakun , Harmontree Sasithorn , Pornpunyawut Prapaporn , Suwanbundit Anek , Zhang Shuo , Krings Timo 
Published: July 2020

Abstract

Background Magnetic resonance intracranial black blood vessel imaging (MR-IBBVI) is a new noninvasive method for evaluating intracranial vessel wall pathology. No previous studies have investigated the efficacy of MR-IBBVI to determine aneurysm size. We aimed to identify the precise diagnosis of MR-IBBVI for the detection and measurement of intracranial aneurysm compared with gold standard cerebral digital subtraction angiography (cDSA).

Materials and Methods The retrospective study collected patients of precoiled or postcoiled intracranial aneurysm who were treated at our institute from January 2012 to June 2019 and who had MR-IBBVI, cDSA imaging, and/or three-dimensional time-of-flight sequence of magnetic resonance angiography. The sensitivity and specificity of aneurysm detection by MR-IBBVI and the accuracy of MR-IBBVI for measuring the aneurysm and vessel size were calculated.

Results One hundred and twenty patients (61% female) with 132 aneurysms were included into this study. The mean aneurysm size was 5.3 mm (range: 2.2–22.6). Sensitivity and specificity of MR-IBBVI to detect a small aneurysm were 98.74 and 91.21%, respectively. No statistically significant results were observed between MR-IBBVI and DSA for aneurysm detection or any of the evaluated measurement parameters.

Conclusion MR-IBBVI is an accurate and highly sensitive method to detect and evaluate the size of an intracranial aneurysm both before and after coiling.
Progesterone Receptor Expression and Score Differences in Determining Grade and Subtype of Meningioma
Authors: Poniman Jeni , Cangara Muh Husni , Kaelan Cahyono , Miskad Upik A. , Arsyadi Gunawan , Ghaznawe Mahmud , Daud Dasril , Ihwan Andi , Rosyidi Rohadi Muhammad 
Published: July 2020

Abstract

Background Meningioma is the most common brain tumor in which therapy and monitoring depend on the histopathological grade (World Health Organization [WHO] Grade). Progesterone receptor (PR) expression was reported positive in meningothelial cells and meningiomas with various degrees of positivity. We evaluated PR expression to determine its correlation with WHO Grade and each subtype of meningioma.

Materials and Methods This study used 70 samples of paraffin block that were diagnosed as meningioma and classified into WHO Grade I, II, and III. The paraffin blocks were sectioned in 5 µm thickness and immunohistochemically stained with the anti-PR antibody.

Results PR expression was found positive in WHO Grade I and II groups, but negative in WHO Grade III group with the score of +2 found in clear cell and atypical subtype. These results were statistically significant with p-value < 0.05.

Conclusion PR can be used as an additional marker to determine WHO Grade and subtype of meningioma.
Cross-finger Flap to the Thumb: Quest for an Alternate Donor
Authors: Chitta Madhavi , Malathi Lekshmi , Joseph Aneesh 
Published: July 2020

Abstract
Background Distal thumb injuries are managed by multiple local and regional flaps. The cross-finger flap (CFF) is one versatile flap used to cover such defects. The donor finger to the thumb is classically described to be the index finger (IF). However, with the index finger being the second most important finger, it causes further debilitation of the already injured hand. Our aim was to find an alternate donor finger to spare the index finger.
Methods and Materials A prospective observational study was conducted on 10 patients with distal thumb injuries who were admitted between November 2018 and July 2019. Ring finger (RF) was used as donor for CFF in all the cases. The subjects were assessed for first web space angle, Kapandji score, total range of movement (TRM) of long fingers, and global hand function using Michigan hand outcome questionnaire (MHQ) after flap division.
Results There was no first web contracture and TRM of IF remained unaffected. However, TRM of RF was significantly reduced. But this being a relatively unimportant finger, there was no significant reduction in global hand function, as evaluated by the MHQ score.
Conclusion The ring finger is a good alternative for index finger as donor for CFF to the thumb, because it provides adequate tissue along with comfortable positioning and easy maintenance of local hygiene. Moreover, it preserves global hand function by sparing the IF.