bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiences of advanced clinical practitioners in training and their supervisors in primary care using a hub and spoke model
Authors: Gloster Annabella Satu , Tomlins Lucy , Murphy Neil 
Published: August 2020

Advanced clinical practitioners are in demand in primary care. This study looked at the experiences of participants in a hub and spoke training model using a qualitative approach Background: Advanced clinical practitioners (ACPs) have been fundamental in ensuring the provision of expert care, resulting in an increase in demand in primary care. This demand has incentivised innovation in approaches to education, to maximise the benefits of training with limited resources and harnessing the expertise in the workforce. Aim: To develop a method of educating and supervising advanced clinical practitioners in training (ACPiTs) in primary care settings situated in a novel hub and spoke environment. Methods: A qualitative approach with close methodological links to the philosophical work of Heidegger was used to capture the nature of existence and reality in the hub and spoke environment. Results: Three main themes emerged from the study: support; supervision; and vision. Conclusion: The hub and spoke format of training is a useful alternative to traditional methods in developing practitioners who work in a bespoke yet broad practice environment, such as primary care.
High-performance humidity sensor based on a micro-nano fiber Bragg grating coated with graphene oxide
Authors: Tian Meng , Huang Yanhua , Li Cong , Lv Min 
Published: August 2020

A high-performance relative humidity (RH) sensor based on a micro-nano fiber Bragg grating (MFBG) coated with a graphene oxide (GO) film is fabricated with a chemical corrosion technique and optically driven deposition method. The diameter of MFBG is corroded to about 12 µm. GO film with the thickness of about 2.5 µm is uniformly coated on the MFBG surface. The change of RH results in the change of refractive index (RI) of GO film, that is, the change of effective RI of MFBG, which will at last result in the shift of reflected wavelength. The experimental results show that there is a good linear relationship between the wavelength shift of MFBG and RH changes in the RH range of 20% to 80% at constant temperature. The sensitivity is 17.361 pm/RH% and the linear correlation coefficient is 99.89%. In order to eliminate the impact of temperature cross sensitivity, the relative measurement is adopted and similar results are obtained. The average response and recovery times are measured to be about 3.2 s and 8.3 s, respectively. The sensor has the advantages of long stability, reversibility, quick response and simple structure. With such high performance, it can be used in widespread potential fields, such as biology, chemical processing and food processing.
Discrete dispersion scan setup for measuring few-cycle laser pulses in the mid-infrared
Authors: Geib Nils C. , Hollinger Richard , Haddad Elissa , Herrmann Paul , Légaré François , Pertsch Thomas , Spielmann Christian , Zürch Michael , Eilenberger Falk 
Published: August 2020

In this work, we demonstrate a discrete dispersion scan scheme using a low number of flat windows to vary the dispersion of laser pulses in discrete steps. Monte Carlo simulations indicate that the pulse duration can be retrieved accurately with less than 10 dispersion steps, which we verify experimentally by measuring few-cycle pulses and material dispersion curves at 3 and 10 µm wavelength. This minimal measuring scheme using only five optical components without the need for linear positioners and interferometric alignment can be readily implemented in many wavelength ranges and situations.
Food Futures: How Design and Technology Can Reshape Our Food System, Chloé Rutzerveld (2018)
Authors: Fuster Albert 
Published: August 2020

Review of: Food Futures: How Design and Technology Can Reshape Our Food System, Chloé Rutzerveld (2018)
Amsterdam: BIS Publishers, 120 pp.,
ISBN 978-9-06369-517-0, p/bk, €24.99
Multiangular spectra of tree bark for common boreal tree species in Europe
Authors: Juola Jussi , Hovi Aarne , Rautiainen Miina 
Published: August 2020

Despite the importance of spectral properties of woody tree structures, they are seldom represented in research related to forests, remote sensing, and reflectance modeling. This study presents a novel imaging multiangular measurement set-up that utilizes a mobile handheld hyperspectral camera (Specim IQ, 400â1000 nm), and can measure stem bark spectra in a controlled laboratory setting. We measured multiangular reflectance spectra of silver birch ( Roth), Scots pine ( L.) and Norway spruce ( (L.) Karst.) stem bark, and demonstrated the potential of using bark spectra in identifying tree species using a Support Vector Machine (SVM) based approach. Intraspecific reflectance variability was the lowest in visible (400â700 nm), and the highest in near-infrared (700â1000 nm) wavelength regions. Interspecific variation was the largest in the red, red-edge and near-infrared spectral bands. Spatial variation of reflectance along the tree height and different sides of the stem (north and south) were found. Both birch and pine had increased reflectance in the forward-scattering directions for visible to near-infrared wavelength regions, whilst spruce displayed the same only for the visible wavelength region. In addition, spruce had increased reflectance in the backward-scattering directions. In spite of the intraspecific variations, SVM could identify tree species with 88.8% overall accuracy when using pixel-specific spectra, and with 97.2% overall accuracy when using mean spectra per image. Based on our results it is possible to identify common boreal tree species based on their stem bark spectra using images from mobile hyperspectral cameras.Betula pendulaPinus sylvestrisPicea abies
Acute Severe Liver Injury Related to Long-Term Garcinia cambogia Intake
Authors: Ferreira Victor , Mathieu Alexandre , Soucy Geneviève , Giard Jeanne-Marie , Erard-Poinsot Domitille 
Published: August 2020

ABSTRACT
Herbal and dietary supplements are frequently used as weight loss supplements. However, they account for 20% of drug-induced liver injury. Garcinia cambogia's (GC) active compound, hydroxycitric acid, can be found among those supplements. We report a 26-year-old woman who had been taking GC for 7 months when she presented with subacute liver failure and ultimately required a liver transplantation. This report highlights the risk of liver injury after long-term use of GC and demonstrates the importance of considering a close and prolonged monitoring of patients in a tertiary liver transplant center.
Fluorescence biomarkers of malignant melanoma detectable in urine
Authors: Špaková Ivana , Dubayová Katarína , Nagyová Vladimíra , Mareková Mária 
Published: August 2020

AbstractMalignant melanoma (MM) is a cancerous transformation of melanocytes. It is a disease with the worst response to therapy and, compared to other malignancies, presents much earlier with metastases. MM still belongs to relatively late-detected malignant diseases. Even so, the MM mortality rate is up to 96% for a relatively small incidence (5%). The gold standard for MM diagnosis is a histopathological examination that requires invasive surgery. An invasive sampling method of a biological material can be a stressful factor for the patient, which is often the reason why patients do not seek medical assistance as soon as possible. Our goal was to find a link between metabolites in urine and the stage of MM. Two excitation peaks at 360–370 nm and 450 nm were characterised in spectra of urine samples. The emission spectra have shown one significant peak at 410–460 nm. After addition of glutathione reductase to the samples, fluorescence dropped down only in patient samples and hidden fluorophores appeared. Malignant diseases are associated with the presence of specific metabolites that can be detected fluorescently in biological material such as urine, which can be a suitable alternative for an early detection of cancer or for tracking changes during and after treatment.
Formation of ruthenium nanoparticles inside aluminosilicate nanotubes and their catalytic activity in aromatics hydrogenation: the impact of complexing agents and reduction procedure
Authors: Stavitskaya Anna , Glotov Aleksandr , Mazurova Kristina , Nedolivko Vladimir , Gushchin Pavel , Huang Wei , Karakhanov Eduard , Vinokurov Vladimir 
Published: August 2020

Abstract
Ruthenium particles with size from 1 to 7 nm were formed by reduction of ruthenium complexes with urea, ethylenediaminetetraacetic acid, acetone azine, 1,2-Bis(2-furylmethylene)hydrazine) inside halloysite nanotubes. Catalysts of different morphology with Ru content from 0.75 to 0.93 %wt. were obtained using NaBH4 or H2 as reducing agents and tested in benzene hydrogenation as a model reaction. NaBH4 reduced catalysts showed similar catalytic activity with 100 % benzene conversion after 1.5 h. Reduction with H2 resulted in a decrease of catalytic activity for all samples. High benzene conversion was achieved only in the case of 1,2-Bis(2-furylmethylene)hydrazine and ethylenediaminetetraacetic acid. It was concluded that the thermal stability of complexing agents plays a key role in activity of catalysts reduced with H2.
Pd(0)-catalyzed amination in the synthesis of chiral derivatives of BINAM and their evaluation as fluorescent enantioselective detectors
Authors: Averin Alexei D. , Grigorova Olga K. , Malysheva Anna S. , Shaferov Alexander V. , Beletskaya Irina P. 
Published: August 2020

Abstract
A mini-review covers recent successes in the synthesis of (S)-1,1′-binaphthyl-2,2′-diamine (BINAM) using Pd(0)-catalyzed amination reactions. As a result, versatile compounds with C2-chiral backbone were synthesized, among them are derivatives bearing additional chiral amino and fluorophore groups like dansyl amide, 7-methoxycoumarin, 6-aminoquinoline, different macrocyclic compounds with oxadiamine and polyamine linkers were obtained as well. BINAM derivatives of various structures were evaluated as fluorescent enantioselective detectors for a series of model amino alcohols. Many of them were shown to be efficient in sensing certain enantiomers of the amino alcohols by selective changes in the emission in the presence of these analytes. Small changes in the structure of the BINAM derivatives lead to serious difference in the recognition ability of the compounds under investigation.
School-Aged Anthropometric Outcomes After Endoscopic or Open Repair of Metopic Synostosis
Authors: Ha Austin Y. , Skolnick Gary B. , Chi David , Nguyen Dennis C. , Naidoo Sybill D. , Smyth Matthew D. , Patel Kamlesh B. 
Published: August 2020

BACKGROUND AND OBJECTIVES:
Metopic craniosynostosis can be treated by fronto-orbital advancement or endoscopic strip craniectomy with postoperative helmeting. Infants younger than 6 months of age are eligible for the endoscopic repair. One-year postoperative anthropometric outcomes have been shown to be equivalent, with significantly less morbidity after endoscopic treatment. The authors hypothesized that both repairs would yield equivalent anthropometric outcomes at 5-years postoperative.

METHODS:
This study was a retrospective chart review of 31 consecutive nonsyndromic patients with isolated metopic craniosynostosis treated with either endoscopic or open correction. The primary anthropometric outcomes were frontal width, interfrontal divergence angle, the Whitaker classification, and the presence of lateral frontal retrusion. Peri-operative variables included estimated blood loss, rates of blood transfusion, length of stay, and operating time.

RESULTS:
There was a significantly lower rate of lateral frontal retrusion in the endoscopic group. No statistically significant differences were found in the other 3 anthropometric outcomes at 5-years postoperative. The endoscopic group was younger at the time of surgery and had improved peri-operative outcomes related to operating time, hospital stay and blood loss. Both groups had low complication and reoperation rates.

CONCLUSIONS:
In our cohort of school-aged children with isolated metopic craniosynostosis, patients who underwent endoscopic repair had superior or equivalent outcomes on all 4 primary anthropometric measures compared with those who underwent open repair. Endoscopic repair was associated with significantly faster recovery and decreased morbidity. Endoscopic repair should be considered in patients diagnosed with metopic craniosynostosis before 6 months of age.
Congenital coronary artery fistula to the right atrium assessed with Cardiac CT
Authors: Maffei Erica , Di Pede Francesco , Barbieri Elisabetta , Cademartiri Filippo 
Published: August 2020

AbstractA 50-year-old female with palpitations, dyspnoea and slightly dilated left ventricle at echocardiography was referred to Cardiac CT (CCT) for coronary artery assessment. CCT revealed a large fistula from the left main coronary artery to the right atrium, associated with agenesia of the inferior vena cava.
Effect of genetic and environmental influences on hepatic steatosis: A classical twin study based on computed tomography
Authors: Jermendy György , Kolossváry Márton , Dudás Ibolya , Jermendy Ádám L. , Panajotu Alexisz , Suhai Imre F. , Drobni Zsófia D. , Karády Júlia , Tárnoki Ádám D. , Tárnoki Dávid L. , Voros Szilard , Merkely Béla , Maurovich-Horvat Pál 
Published: August 2020

AbstractBackground and aimsNon-alcoholic fatty liver disease (NAFLD) increases cardiovascular morbidity and mortality, and carries poor long-term hepatic prognosis. Data about the role of genetic and environmental factors in the hepatic lipid accumulation are limited. The aim of the study was to evaluate the genetic and environmental impact on the hepatic lipid accumulation within a cohort of adult twin pairs.Patients and methodsWe investigated 182 twin subjects [monozygotic (MZ,n= 114) and dizygotic (DZ,n= 68) same-gender twins (age 56.0 ± 9.6 years; BMI 27.5 ± 5.0 kg/m2; females 65.9%)] who underwent computed tomography (CT) with a 256-slice scanner. Using non-enhanced CT-images, we calculated the average value of hepatic attenuation [expressed in Hounsfield unit (HU)] suggesting hepatic lipid content. Crude data were adjusted to age, sex, BMI and HbA1c values. Intra-pair correlations were established, and structural equation models were used for quantifying the contribution of additive genetic (A), common environmental (C) and unique environmental (E) components to the investigated phenotype.ResultsThe study cohort represented a moderately overweight, middle-aged Caucasian population. There was no significant difference between MZ and DZ twin subjects regarding hepatic CT-attenuation (57.9 ± 12.6 HU and 59.3 ± 11.7 HU, respectively;p= 0.747). Age, sex, BMI and HbA1c adjusted co-twin correlations between the siblings showed that MZ twins have stronger correlations of HU values than DZ twins (rMZ = 0.592,p< 0.001; rDZ = 0.047,p= 0.690, respectively). Using the structural equation model, a moderate additive genetic dependence (A: 38%, 95% CI 15–58%) and a greater unique environmental influence (E: 62%, 95% CI 42–85%) was found. Common environmental influence was not identified (C: 0%).ConclusionThe results of our classical CT-based twin study revealed moderate genetic and greater environmental influences on the phenotypic appearance of hepatic steatosis, commonly referred to as NAFLD. Favorable changes of modifiable environmental factors are of great importance in preventing or treating NAFLD.
Qualidade de vida em crianças obesas participantes de um programa de intervenção com exercícios físicos
Authors: Viana Raytta Silva , Reis Marina Melo , Santos Amanda , Lagoa Maria João Da Cruz , Andaki Alynne Christian Ribeiro 
Published: August 2020

A obesidade pediátrica pode afetar a qualidade de vida (QV) da criança em diversos aspectos da saúde, sejam eles físicos ou psicossociais e sua mensuração é considerada um importante parâmetro na avaliação e tratamento de crianças com excesso de peso. O objetivo do estudo foi avaliar o efeito de um programa de intervenção com exercício físico sobre a QV de crianças com sobrepeso ou obesidade. Estudo se caracterizou como um ensaio clínico não randomizado e controlado e a amostra foi composta por 45 crianças entre oito e 11 anos de idade, com Índice de Massa Corporal (IMC) acima do percentil 85 para idade e sexo. Os participantes foram divididos em 3 grupos, grupo controle (n=22), grupo intervenção quadra (n=11) e grupo intervenção piscina (n=12). As crianças realizaram avaliação antropométrica para cálculo do IMC. A QV foi avaliada pelo questionário PedsQL versão genérica para crianças e pais, validado para a população brasileira. O teste ANCOVA univariada foi aplicado na comparação entre os grupos, com nível de significância α=5%. Observou-se diferença significativa no autorrelato das crianças, entre os grupos, em relação ao domínio Atividade Escolar (Δ GIP ≠ GC, Δ GIP =GIQ; p = 0,05) e verificou-se diferença significativa entre o autorrelato das crianças comparado aos questionários respondidos pelos pais, no domínio Atividade Escolar (p = 0,03) e QV geral (p = 0,02). Conclui-se que um programa de intervenção com exercícios físicos provocou efeito nos escores do domínio Atividade Escolar e QV geral de crianças com excesso de peso, com alterações significativas na percepção dos pais em relação as crianças.
Pharmacogenomics biomarkers for personalized methadone maintenance treatment: The mechanism and its potential use
Authors: Ramli Fitri Fareez 
Published: August 2020

Methadone has a wide pharmacokinetic interindividual variability, resulting in unpredicted treatment response. Pharmacogenomic biomarkers seem promising for personalized methadone maintenance treatment. The evidence supports the use of ABCB1 SNP 1236C>T with genotypes C/T or C/C (Jewish) and haplotypes AGCTT carrier, AGCGC heterozygote, or non-carrier (Caucasian), which have a predicted lower methadone dose requirement. In contrast, ABCB1 SNP 1236C>T with genotype T/T (Jewish); haplotypes AGCGC homozygote, AGCTT non-carrier (Caucasian), and ABCB1 3435C>T variant carrier; and haplotypes CGT, TTC, and TGT (Han Chinese) have a predicted higher methadone dose. For methadone plasma levels, ABCB1 diplotype non-CGC/TTT (Malay) predicted lower, and diplotype CGC/TTT (Malay), 3435C>T allelic carrier, haplotypes (CGT, TTC, TGT) (Han Chinese) predicted higher methadone levels. In terms of metabolism biomarkers, a lower methadone requirement was related to carriers of CYP2B6 genotypes *4(G/G) and *9(T/T) among Jewish patients, CYP2B6*9 genotype (T/T) and haplotypes (TA/TG); and CYP2C19 (*2/*2,*2/*3, and *3/*3; Han Chinese). Higher methadone dose was observed in CYP2C19*1 allelic carriers (Han Chinese) and CYP2D6 ultrarapid metabolizer (Caucasian). Lower methadone levels were reported in CYP2B6 SNPs, haplotypes TTT, and AGATAA (Han Chinese), CYP2C19 genotype *1/*1 (Han Chinese), allelic carrier *1xN (Caucasian), and CYP3A4 genotype *1/*1 (Caucasian). Carriers of CYP2B6 genotype *6/*6 (Caucasian), CYP2B6 haplotypes ATGCAG and ATGCTG (Han Chinese), and CYP3A4 genotype *1/*1B (Caucasian) had predicted higher methadone plasma levels. Specific pharmacokinetics biomarkers have potential uses for personalized methadone treatment in specific populations.
Discussion on Remote Sensing Big Data to Promote the Development of Smart City
Authors: Jiang Ying , Yin Jian , Zha Libin 
Published: August 2020

<p>With the development and application of Internet technology, cloud computing, big data technology, Internet of things technology and other new generation information technology, smart city has gradually become the focus of global urban development. Remote sensing technology big data is the combination of remote sensing technology and big data technology. Remote sensing technology has the characteristics of long-distance, non-contact detection and wide coverage. And the data information collected by remote sensing equipment is analyzed by using big data technology to improve the application value of remote sensing technology. This paper first describes the characteristics of remote sensing big data and the connotation of smart city, and that the remote sensing big data technology can promote the intelligent supervision of urban pollution, urban planning, urban traffic intelligent response, and construction more reasonable and humanized, then it can help realize the development of urban traffic intelligent.</p>
OBSTACLES AND STRATEGIES IN DEVELOPING HALAL INDUSTRY: EVIDENCE FROM INDONESIA
Authors: Widiastuti Tika , Rusydiana Aam Slamet , Robani Anidah , Insani Taqiyah Dinda , Muryani  
Published: August 2020

Purpose of the study: Indonesia is a country with a majority of the Muslim population and the development of the halal industry should be the main focus. This study aims at examining the obstacles of halal industry development in Indonesia. It also attempts to provide strategies on how to accelerate the development of the halal industry in Indonesia.
Methodology: This study used a qualitative research approach with the Analytic Network Process (A.N.P.) analysis techniques. This analysis process is supported by Microsoft Excel and A.N.P. software (Superdecisions). The analysis results from A.N.P. are in the order of priority. Because the A.N.P. analysis technique only uses the opinions of the experts, the results of this study will be robust enough.
Main Findings: Based on the results of literature and in-depth interviews with experts, there are several important obstacles related to the development of the halal industry in Indonesia. Those obstacles are policy, production, socialization, infrastructure, and human resources. Based on the A.N.P. analysis result, from five groups found, the biggest weight is the human resource, infrastructure, production, policy, and socialization.
Applications of this study: This research compiles the development strategy of the halal industry in Indonesia based on the priority obstacles agreed by the experts. This strategy focuses on the role of four economic participants, namely governments, consumers, investors, and industry. Therefore, it will be easier to continue the strategy into the halal industry development program in Indonesia.
Novelty/Originality of this study: This study considers the priority of obstacles in the purposing strategy for developing the halal industry in Indonesia, which has never been done in previous studies. In addition, the analysis technique used refers to the opinions of experts in the Indonesian halal industry, so the results can be more applicable.
Systemic and Organ-Specific Insulin Sensitizing Mechanisms of PAHSAs-Comments on Zhou and Santoro et al. PAHSAs Enhance Hepatic and Systemic Insulin Sensitivity through Direct and Indirect Mechanisms, J Clin Invest. 2019;129(10):4138–4150
Authors: Kumari Manju , Heeren Joerg , Scheja Ludger 
Published: August 2020

Abstract
Fatty acid esters of hydroxy fatty acids (FAHFAs) have been identified as a novel class of bioactive lipids with beneficial effects on insulin secretion, glucose metabolism and metabolic inflammation. Palmitic acid-hydroxystearic acids (PAHSAs), a subgroup of FAHFAs, are reduced in serum and fat of insulin resistant mice and humans. A recent paper complements previous studies by demonstrating that exogenous PAHSAs act as insulin sensitizers in mice with a strong action on liver through both direct (inhibiting cyclic AMP signaling in hepatocytes) and indirect (reducing adipose tissue lipolysis and its contribution to hepatic glucose production) effects.