bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computing skew left braces of small orders
Authors: Bardakov Valeriy G. , Neshchadim Mikhail V. , Yadav Manoj K. 
Published: December 2019

We improve Algorithm 5.1 of [Math. Comp. 86 (2017) 2519–2534] for computing all nonisomorphic skew left braces, and enumerate left braces and skew left braces of orders up to 868 with some exceptions. Using the enumerated data, we state some conjectures for further research.
A generalized Frattini subgroup
Authors: Borodich Ruslan V. 
Published: December 2019

In the work of Beidleman and Smith [On Frattini-like subgroups, Glasgow Math. J. 35 (1993) 95–98], the following question was raised: “If [Formula: see text] is a subnormal subgroup of a finite group [Formula: see text] containing [Formula: see text], then whether the supersolvability of [Formula: see text] follows the supersolvability of [Formula: see text]”. This problem was considered in works of Selkin [Maximal Subgroups in the Theory of Classes of Finite Groups (Belaruskaya, Navuka, 1997)], Skiba [On the intersection of all maximal [Formula: see text]-subgroups of a finite group, Prob. Phys. Math. Tech. 3(4) (2010) 56–62], Ballester-Bolinches [On [Formula: see text]-subnormal subgroups and Frattini-like subgroups of a finite group, Glasgow Math. J. 36 (1994) 241–247] and many other authors (see monograph [Maximal Subgroups in the Theory of Classes of Finite Groups (Belaruskaya, Navuka, 1997)]). In this paper, we give the answer to the more general question: “Let [Formula: see text] be a local formation. If [Formula: see text] is a subnormal subgroup of a group [Formula: see text], then in what case [Formula: see text] will follow from [Formula: see text]”.
RYK, a receptor of noncanonical Wnt ligand Wnt5a, is positively correlated with gastric cancer tumorigenesis and potential of liver metastasis
Authors: Fu Yongan , Chen Yilin , Huang Jinghua , Cai Zongda , Wang Yangqiang 
Published: December 2019

Gastric cancer (GC) is the most prevalent human cancer around the globe. In GC, Wnt signaling is deregulated, and receptor-like tyrosine kinase (RYK) coreceptors have been identified to interact with noncanonical Wnt ligand Wnt5a. We, therefore, aimed to evaluate the role of RYK in GC development and metastasis. GC tumor samples were collected from 250 GC patients. Expressions of RYK, as well as markers for the epithelial-mesenchymal transition (EMT), such as N-cadherin and E-cadherin, were subjected to correlation analysis with clinicopathological features. Endogenous RYK expression levels were compared in GC cell lines with ascending metastatic potentials followed by stable RYK knockdown. Effect of RYK knockdown on GC cell migration, invasion, and EMT phenotype were assessed in vitro, and on GC tumor growth in vivo in a xenograft rodent model. Particularly, liver metastasis potential of tail vein-injected GC cells was also analyzed following RYK knockdown. RYK was highly correlated with liver metastasis of GC tumors and the expression profiles of EMT markers toward the mesenchymal tendency. RYK expression was also positively correlated with the metastasis potential of GC cells. RYK knockdown not only inhibited migration, invasion, and EMT of GC cells in vitro, but also suppressed tumorigenesis and liver metastasis of GC cells in vivo using the mouse xenograft model. RYK is highly correlated with GC tumorigenesis and potential of liver metastasis, suggesting it may be a novel oncogenic factor of the noncanonical Wnt signaling pathway contributing to GC. NEW & NOTEWORTHY RYK is highly correlated with gastric cancer tumorigenesis and the potential of liver metastasis, suggesting it may be a novel oncogenic factor of the noncanonical Wnt signaling pathway contributing to gastric cancer.
Prevalence of Inherited Mutations in Breast Cancer Predisposition Genes among Women in Uganda and Cameroon
Authors: Adedokun Babatunde , Zheng Yonglan , Ndom Paul , Gakwaya Antony , Makumbi Timothy , Zhou Alicia Y. , Yoshimatsu Toshio F. , Rodriguez Alex , Madduri Ravi K. , Foster Ian T. , Sallam Aminah , Olopade Olufunmilayo I. , Huo Dezheng 
Published: December 2019

Abstract

Background:
Sub-Saharan Africa (SSA) has a high proportion of premenopausal hormone receptor negative breast cancer. Previous studies reported a strikingly high prevalence of germline mutations in BRCA1 and BRCA2 among Nigerian patients with breast cancer. It is unknown if this exists in other SSA countries.

Methods:
Breast cancer cases, unselected for age at diagnosis and family history, were recruited from tertiary hospitals in Kampala, Uganda and Yaoundé, Cameroon. Controls were women without breast cancer recruited from the same hospitals and age-matched to cases. A multigene sequencing panel was used to test for germline mutations.

Results:
There were 196 cases and 185 controls with a mean age of 46.2 and 46.6 years for cases and controls, respectively. Among cases, 15.8% carried a pathogenic or likely pathogenic mutation in a breast cancer susceptibility gene: 5.6% in BRCA1, 5.6% in BRCA2, 1.5% in ATM, 1% in PALB2, 0.5% in BARD1, 0.5% in CDH1, and 0.5% in TP53. Among controls, 1.6% carried a mutation in one of these genes. Cases were 11-fold more likely to carry a mutation compared with controls (OR = 11.34; 95% confidence interval, 3.44–59.06; P &lt; 0.001). The mean age of cases with BRCA1 mutations was 38.3 years compared with 46.7 years among other cases without such mutations (P = 0.03).

Conclusions:
Our findings replicate the earlier report of a high proportion of mutations in BRCA1/2 among patients with symptomatic breast cancer in SSA.

Impact:
Given the high burden of inherited breast cancer in SSA countries, genetic risk assessment could be integrated into national cancer control plans.
Association between Concomitant Use of Hydrochlorothiazide and Adverse Chemotherapy-Related Events among Older Women with Breast Cancer Treated with Cyclophosphamide
Authors: Hsu Christine D. , Hinton Sharon Peacock , Reeder-Hayes Katherine E. , Sanoff Hanna K. , Lund Jennifer L. 
Published: December 2019

Abstract

Background:
The pharmacy reference database, Micromedex, lists concomitant hydrochlorothiazide and cyclophosphamide use as a potential, major drug–drug interaction (DDI), although only one small, single-center study supports this claim. Our objective was to estimate associations between this potential DDI and two adverse chemotherapy-related events, neutropenia-related hospitalizations and treatment regimen discontinuation, among a cohort of women with breast cancer initiating adjuvant chemotherapy containing cyclophosphamide.

Methods:
Using linked Surveillance, Epidemiology, and End Results Program (SEER)-Medicare data, we included women 66 years and older with breast cancer diagnosis between 2007 and 2011, who initiated a regimen containing cyclophosphamide. Risk ratios (RR) and 95% confidence intervals for adverse outcomes comparing women exposed versus unexposed to the potential DDI were assessed using modified multivariable Poisson regression adjusting for potential confounders.

Results:
In total, 27% of women receiving cyclophosphamide treatment were exposed to concomitant hydrochlorothiazide, of which 11% experienced a neutropenia-related hospitalization and 21% discontinued their chemotherapy regimen prior to completion. Adjusted risks of both adverse events were similar between those exposed and unexposed to the potential DDI [neutropenia-related hospitalization: adjusted RR (aRR) = 0.92 (0.70–1.21); treatment discontinuation: aRR = 1.00 (0.96–1.05)].

Conclusions:
Our results do not support an association between concomitant hydrochlorothiazide use and two clinically relevant adverse chemotherapy-related events.

Impact:
Our results support reassessing and potentially lowering severity of this potential interaction in drug reference databases.
High-Throughput Generation of Bispecific Binding Proteins by Sortase A–Mediated Coupling for Direct Functional Screening in Cell Culture
Authors: Andres Fabio , Schwill Martin , Boersma Ykelien L. , Plückthun Andreas 
Published: December 2019

Abstract
High-throughput construction of multivalent binders and subsequent screening for biological activity represent a fundamental challenge: A linear increase of monovalent components translates to the square of possible bivalent combinations. Even high-efficiency cloning and expression methods become limiting when thousands of bispecific binders need to be screened for activity. In this study, we present an in vitro method for the efficient production of flexibly linked bispecific binding agents from individually expressed and purified monovalent binders. We established a sortase A–mediated coupling reaction to generate bispecific designed ankyrin repeat proteins (DARPins), with an optimized reaction maximizing the bivalent coupling product with low levels of monovalent side-products. These one-pot reaction mixtures could be used directly, without further purification, in cell-based assays. We generated a matrix of 441 different bispecific DARPins against the extracellular domains of the cancer-associated receptors EGFR, ErbB2, ErbB3, ErbB4, EpCAM, and c-MET and screened on two different ErbB2-positive cancer cells lines for growth-inhibitory effects. We identified not only known but also novel biologically active biparatopic DARPins. Furthermore, we found that the cancer cell lines respond in a highly reproducible and defined manner to the treatment with the 441 different bivalent binding agents. The generated response profiles can thus be used for functional characterization of cell lines because they are strongly related to the cell line–specific surface receptor landscape. Thus, our method not only represents a robust tool for screening and lead identification of bispecific binding agents, but additionally offers an orthogonal approach for the functional characterization of cancer cell lines.
Performance of HPV Genotyping Combined with p16/Ki-67 in Detection of Cervical Precancer and Cancer Among HPV-Positive Chinese Women
Authors: Jiang Ming-Yue , Wu Zeni , Li Tingyuan , Yu Lulu , Zhang Shao-Kai , Zhang Xun , Qu Pengpeng , Sun Peisong , Xi Ming-Rong , Liu Xin , Liao Guangdong , Sun Lixin , Zhang Yongzhen , Chen Wen , Qiao You-Lin 
Published: December 2019

Abstract
Women with positive high-risk human papillomavirus (hrHPV) need efficient triage testing to determine colposcopy referrals. Triage strategies of combining p16/Ki-67 with extended HPV genotyping were evaluated in this study. In total, 899 women attending cervical cancer screening program and 858 women referred to colposcopy from five hospitals were recruited. All the participants were tested by HPV assays and p16/Ki-67 dual staining. Colposcopy and biopsy were performed on women with any abnormal results. HPV genotypes were divided into four strata (HPV16/18, HPV31/33/58/52, HPV45/59/56/66, and HPV51/39/68/35) according to their risks for cervical intraepithelial neoplasia grade 3 or worse (CIN3+). The positive rates of four genotype strata among CIN3+ women were 3.47% (HPV51/39/68/35), 7.73% (HPV45/59/56/66), 14.7% (HPV31/33/58/52), and 78.1% (HPV16/18), respectively (Ptrend &lt; 0.001). The positive rates of p16/Ki-67 increased with the elevation of HPV risk hierarchical from 65.0% in HPV51/39/68/35-positive women to 88.0% in HPV16/18-positive women (Ptrend &lt; 0.001). p16/Ki-67 was an effective method for risk stratification of CIN2+ among HPV31/33/58/52- and HPV45/59/56/66-positive women [HPV31/33/58/52: OR for dual stain+ (ORDS+) of 26.7 (16.8–42.4) and OR for dual stain− (ORDS−) of 3.87(1.89–7.91); HPV45/59/56/66: ORDS+ of 10.3(5.05–21.0) and ORDS− of 1.27(0.38–4.26)]. The combination of HPV16/18 genotyping and p16/Ki-67 triage of HPV31/33/58/52/45/59/56/66-positive women resulted in a lower referral rate (40.1% vs. 41.3%; P &lt; 0.001) as compared with triage of 12 other HPV-positive women with p16/Ki-67, although sensitivity and specificity levels for these two strategies were identical. Combining HPV extended genotyping and p16/Ki-67 can be considered as a promising strategy for cervical cancer screening and triage.
Community-Based Upper Gastrointestinal Cancer Screening in a Randomized Controlled Trial: Baseline Results in a Non-high-incidence Area
Authors: Xiao Hai-Fan , Yan Shi-Peng , Chen Yan-fang , Shi Zhaohui , Zou Yan-Hua , Zhu Song-lin , Xu Ke-Kui , Song Ting , Liao Xian-Zhen 
Published: December 2019

Abstract

A cluster-randomized controlled trial (RCT) was conducted to evaluate to the effectiveness of reducing mortality of upper gastrointestinal cancer (UGC) and feasibility of screening through a questionnaire combined with endoscopy in non-high-incidence urban areas in China. The trial design, recruitment performance, and preliminary results from baseline endoscopy are reported. Seventy-five communities in two urban cities with a non-high-incidence of UGC were randomized to a screening endoscopy arm (n = 38) or a control arm (n = 37). In the screening arm, individuals at high risk of UGC underwent endoscopic screening. The primary outcome was the UGC mortality, and secondary outcomes included the UGC detection rate, incidence rate, survival rate, and clinical stage at the time of diagnosis. A total of 10,416 and 9,565 individuals were recruited into the screening and control arms, respectively. The participation rate was 74.3%. In the screening arm, 5,242 individuals (50.3%) were estimated to be high-risk. Among them, 2,388 (45.6%) underwent endoscopic screening. Age and household income were associated with undergoing endoscopy. Three early esophageal cancer (0.13%), one gastric cancer (0.04%), 29 precancerous esophageal lesions (1.21%), and 53 precancerous gastric lesions (2.22%) were detected. Age, sex, a family history of cancer, intake of meat–egg–milk frequently, superficial gastritis, and clinical symptoms of gastric cancer were associated with the presence of precancerous lesions. The detection rate was low using endoscopic screening in non-high-incidence area given the relatively low compliance rate. These findings provide a reference for designing effective community-based UGC screening strategies in non-high-incidence urban areas.
Repeated Endovascular Thrombectomy in Patients With Acute Ischemic Stroke
Authors: Pirson France Anne Victoire , van Oostenbrugge Robert J. , van Zwam Wim H. , Remmers Michel J.M. , Dippel Diederik W.J. , van Es Adriaan C.G.M. , van den Wijngaard Ido R. , Schonewille Wouter J. , Staals Julie 
Published: December 2019

Background and Purpose—
Patients with acute ischemic stroke treated with endovascular thrombectomy may be treated with repeat endovascular thrombectomy (rEVT) in case of recurrent large vessel occlusion. Data on safety and efficacy of these interventions is scarce. Our aim is to report on frequency, timing, and outcome of rEVT in a large nation-wide multicenter registry.

Methods—
In the Netherlands, all patients with endovascular thrombectomy have been registered since 2002 (MR CLEAN Pretrial registry, MR CLEAN Trial [Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands], and MR CLEAN Registry). We retrospectively reviewed these databases for anterior circulation rEVT cases. Patient characteristics, procedural data, and functional outcome (modified Rankin Scale at 90 days) were analyzed.

Results—
Of 3928 patients treated between 2002 and 2017, 27 (0.7%) underwent rEVT. Median time between first and second procedure was 78 (1–1122) days; 11/27 patients were re-treated within 30 days. Cardioembolism was the most common etiology (18 patients [67%]). In 19 patients (70%), recurrent occlusion occurred ipsilateral to previous occlusion. At 90 days after rEVT procedure, 44% of the patients had achieved functional independence (modified Rankin Scale score of 0–2), and 33% had died. Adverse events were 2/27 (7.4%) intracranial hemorrhage, 1/27 (3.7%) stroke progression, and 1/27 (3.7%) pneumonia.

Conclusions—
In this large nationwide cohort of patients with acute ischemic stroke treated with endovascular thrombectomy, rEVT was rare. Stroke cause was mainly cardio-embolic, and most recurrent large vessel occlusions in which rEVT was performed occurred ipsilateral. Although there probably is a selection bias on repeated treatment in case of recurrent large vessel occlusion, rEVT appears safe, with similar outcome as in single-treated cases.
Performance of resistance in Croatia: A chronotopic review from the 1990s onwards
Authors: Marjanić Suzana 
Published: December 2019

Performance of resistance in Croatia: A chronotopic review from the 1990s onwardsI follow the performance of resistance in performance art in Croatia from the 1990s – i.e. from the disintegration of Yugoslavia – in correlation with the visibility of the performance of resistance in public spaces, with an emphasis on the individual guerrilla action by Igor Grubić (1998), which is considered the first action and provocation in Croatia of the 1990s that was triggered by civic self-initiative. Due to socialist legacy and the war, it was only in 1998 that an action could occur in Croatia that would be as powerful action in terms of media influence as had been the case in the revolutionary year of 1968 in Yugoslavia with the action Red Peristyle, upon the aura of which Grubić’s Black Peristyle was built. I conclude this review of the performance of resistance in Croatia from the 1990s onwards with the story of Black Nylon Peristyle as the civic performative reaction on the occasion of the accession of Croatia to the EU. Thereby I follow chronotopically the performance of resistance in Croatia between 1998 and 2013 (and partly further, up to and including 2017) with regard to the performative centres, placing the starting and endpoint in Split i.e. Peristyle as the art forum of the performance of resistance in Croatia. Performans oporu w Chorwacji. Przegląd chronotopiczny od lat 90.W artykule prześledzono performans oporu w sztuce performansu w Chorwacji od lat dziewięćdziesiątych, tj. od rozpadu Jugosławii – w odniesieniu do kwestii widzialności performansu oporu w sferze publicznej. Akcent został położony na indywidualnej akcji partyzanckiej Igora Grubicia (1998), uważanej za pierwszą akcję i pierwszą prowokację jako przejaw inicjatywy obywatelskiej w Chorwacji w latach dziewięćdziesiątych. W związku z panującą wojną i trwającym okresem postsocjalizmu dopiero w 1998 roku w Chorwacji miało miejsce działanie, które pod względem medialnym było porównywalne do rewolucyjnego roku 1968 w Jugosławii, kiedy to odbyła się interwencja Czerwony Perystyl, do której odnosiło się przedsięwzięcie Grubicia – Czarny Perystyl. Przegląd performansów oporu w Chorwacji od lat dziewięćdziesiątych zamykam opowieścią o Czarnym Nylonowym Perystylu jako obywatelskiej reakcji performatywnej na przystąpienie Chorwacji do Unii Europejskiej. Tym samym śledzę w sposób chronotopiczny performans oporu w Chorwacji w latach 1998–2013 (i częściowo dalej, aż do roku 2017) z uwzględnieniem centrów performatywnych, umieszczając punkt początkowy i końcowy w Splicie, a dokładnie na Perystylu jako artystycznym forum performansu oporu w Chorwacji.
“The yellow duck” attacks: An analysis of the activities of the “Ne da(vi)mo Beograd” initiative in the Serbian public space
Authors: Domachowska Agata 
Published: December 2019

“The yellow duck” attacks: An analysis of the activities of the “Ne da(vi)mo Beograd” initiative in the Serbian public spaceThe main aim of the paper is to present the performative dimension of activities undertaken by the “Ne da(vi)mo Beograd” Initiative. The Initiative’s actions, which initially concerned opposition to the “Belgrade on Water” project, turned into a regular political campaign. These activities clearly illustrate contemporary ways of managing civil opposition, as well as performative practices aimed at creating a civil society. The focus is on verbal and non-verbal practices of expressing resistance, as well as strategies for building a sense of community among the participants of the Initiative’s gatherings. „Żółta kaczka” atakuj. Aanaliza działalności inicjatywy „Ne da(vi)mo Beograd” w serbskiej przestrzeni publicznejCelem artykułu jest przedstawienie performatywnego wymiaru działań podejmowanych przez inicjatywę „Ne da(vi)mo Beograd”. Akcje inicjatywy, początkowo związane ze sprzeciwem wobec projektu „Belgrad na wodzie”, przerodziły się w regularną kampanię polityczną. Działania te dobrze ilustrują współczesne sposoby zarządzania sprzeciwem obywatelskim, a także praktyki performatywne mające na celu tworzenie społeczeństwa obywatelskiego. W centrum zainteresowania znajdują się werbalne i niewerbalne praktyki wyrażania oporu, a także strategie budowania poczucia wspólnotowości wśród uczestników zgromadzeń organizowanych przez inicjatywę.
Memory in action – Performative practices in a dispute about the past: Serbia and Croatia at the turn of the 20th and 21st century
Authors: Giergiel Sabina , Taczyńska Katarzyna 
Published: December 2019

Memory in action – Performative practices in a dispute about the past: Serbia and Croatia at the turn of the 20th and 21st centuryThe article is an attempt to combine in one reflection the elements of two directions of critical thinking: discursive and performative. The starting point of the analysis is the assumption (derived from beliefs common in pre-performative times) that every space (including a city’s territory) can be treated as a text. This means that both static artifacts and activities in a given space communicate a certain message and can be seen as signs or symbols that refer to something outside of them. Our reflection focuses on practices in which the performative potential is fully revealed and which can be interpreted as a kind of rebellion against the present reality and official policies of memory. The analyzed activities are understood here as symbolic and cultural practices and aim to introduce changes on several levels: to change the historical consciousness of community members; to affect the nuances and expansion of national memory (in this case Serbian or Croatian); to modify the nature of memory. We are interested in interventions that are usually undertaken by persons or groups located on the outskirts of the system of power. Pamięć w działaniu – praktyki performatywne w sporze o przeszłość. Serbia i Chorwacja na przełomie XX i XXI wiekuArtykuł stanowi próbę połączenia we wspólnej refleksji elementów dwóch kierunków myślenia krytycznego: dyskursywnego i performatywnego. Punktem wyjścia rozważań jest wywodzące się z przekonań patronujących czasom przedperformatywnym założenie, że każdą przestrzeń (w tym terytorium miasta) można traktować jako tekst. Oznacza to, że zarówno statyczne artefakty, jak i odbywające się w przestrzeni aktywne działania komunikują pewien przekaz i można je rozpatrywać jako znaki bądź symbole odsyłające do czegoś, co jest poza nimi. Nasza refleksja koncentruje się na praktykach, w których z całą mocą ujawnia się potencjał performatywny i które można odczytywać jako rodzaj buntu wobec zastanej rzeczywistości i obowiązujących polityk pamięci. Analizowane działania rozumiane są tutaj jako praktyki symboliczno-kulturowe, które stawiają sobie za cel wprowadzenie przekształceń na kilku poziomach: zmianę świadomości historycznej członków społeczności; wpłynięcie na zniuansowanie i poszerzenie pamięci narodowej (w tym wypadku serbskiej czy chorwackiej); modyfikację charakteru pamięci. Interesują nas interwencje podejmowane zwykle przez osoby bądź grupy sytuujące się na obrzeżach systemu władzy.