bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regional Variability in Lithic Miniaturization and the Organization of Technology in Late Glacial Southern Africa (~18-11 kcal BP)
Authors: Low Marika , Pargeter Justin 
Published: June 2020

Abstract
Miniaturized stone tools made by controlled fracture are reported from nearly every continent where archaeologists have systematically looked for them. While similarities in technology are acknowledged between regions, few detailed inter-regional comparative studies have been conducted. Our paper addresses this gap, presenting results of a comparative lithic technological study between Klipfonteinrand and Sehonghong – two large rock shelters in southern Africa. Both sites contain Late Glacial (~18-11 kcal BP) lithic assemblages, though they are located in regions with different geologies, climates and environments. Results demonstrate that lithic miniaturization manifests differently in these different regions. Both assemblages provide evidence for small blade production, though key differences exist in terms of the specific technological composition of this evidence, the raw materials selected, the role played by bipolar reduction and the manner in which lithic reduction was organized. Patterned variability of this nature demonstrates that humans deployed miniaturized technologies strategically in relation to local conditions.
Two new species and new records in the alpheid shrimp genera Salmoneus Holthuis, 1955 and Deioneus Dworschak, Anker &amp; Abed-Navandi, 2000 in the Atlantic Ocean (Malacostraca: Decapoda)
Authors: ANKER ARTHUR 
Published: June 2020

The present study deals with two species new to science, as well as several new records in the closely related alpheid shrimp genera Salmoneus Holthuis, 1955 and Deioneus Dworschak, Anker & Abed-Navandi, 2000, based on material collected at various localities in the tropical western and eastern Atlantic Ocean. In the western Atlantic, Salmoneus inconspicuus sp. nov. is described based on material from the Caribbean coast of Panama, Cuba, French Antilles and (with some doubts) Bermuda. The new species has been previously reported from the eastern Caribbean Sea as S. teres Manning & Chace, 1990, a closely related species so far known only from Ascension Island in the central Atlantic. Salmoneus camaroncito Anker, 2010 is reported from the Caribbean coast of Mexico, for the first time since its original description. Salmoneus carvachoi Anker, 2007 is reported from Colombia and southeastern USA, representing a new record of the species for each of these countries. Salmoneus depressus Anker, 2011 and Salmoneus setosus Manning & Chace, 1990 are reported for the first time from Cuba and Panama, respectively. In addition, these two species, as well as Salmoneus wehrtmanni Anker, 2010, are reported from new localities in Mexico. In the eastern Atlantic, Salmoneus saotomensis sp. nov. is described based on a single specimen from São Tomé Island in the Gulf of Guinea. The new species is characterised by the somewhat enlarged minor cheliped and is compared to all other Atlantic species presenting this feature. Deioneus sandizelli Dworschak, Anker & Abed-Navandi, 2000 is reported from São Tomé Island, for the first second time since its original description based on the Cape Verde type material. The characters separating Deioneus and Salmoneus are reassessed. The new evidence shows that these two genera are distinguished by only one morphological feature known to be variable in at least one non-related alpheid genus. However, in view of the increasing morphological heterogeneity in Salmoneus, it seems more appropriate to retain Deioneus as a valid genus for it may represent a distinct clade that also includes several other species currently placed in Salmoneus.
Continuing Professional Development Needs of Community Pharmacists in Qatar: A Mixed-Methods Approach
Authors: Al-Sulaiti Fatima , Fares Hebatala , Awaisu Ahmed , Kheir Nadir 
Published: June 2020

Objective This study aims to assess the educational needs and professional competencies of community pharmacists in Qatar to inform the development of relevant continuing professional development (CPD) programs. Methods A mixed-methods cross-sectional exploratory study targeting community pharmacists was conducted using a questionnaire and an event diary. Descriptive and inferential analyses were utilized to analyze the data using the Statistical Package for Social Sciences (SPSS®) version 21 software. For the event diary, thematic content analysis was used for data analysis. Results Drug information skills and pharmaceutical care process were the most identified topics for inclusion in CPD programs. None of the pharmacists thought that they were competent in core areas of pharmacy practice. Community pharmacists who filled an event diary highlighted the need for development in areas such as communication skills and medication safety. Conclusion The identified needs shall help in developing a CPD program that addresses what community pharmacists perceive as educational and professional training needs.
Relationship between maxillary posterior molar roots and the maxillary sinus floor: Cone-beam computed tomography analysis of a western Chinese population
Authors: Pei Jun , Liu Jiyuan , Chen Yafei , Liu Yuanyuan , Liao Xuejuan , Pan Jian 
Published: June 2020

Objective This study aimed to assess the positional relationships between the maxillary sinus and the first and second molars in a western Chinese population by using cone-beam computed tomography. Methods This study included 212 patients (652 maxillary molars and 1956 roots). Patient demographics (sex and age) and cone-beam computed tomography data regarding the relationship between molar roots and the maxillary sinus were obtained. This relationship was stratified into four types for statistical analysis. Results Sex and side did not significantly influence the distance between maxillary molar roots and the maxillary sinus. However, the distance between maxillary molar roots and the maxillary sinus increased with age. The mesiobuccal root of the second molar was nearest to the maxillary sinus. The most common relationship type involved absence of root contact with the sinus border and presence of a maxillary sinus cross-section above the root apex. Conclusions Compared with other teeth, the maxillary posterior teeth have a complex anatomical structure and are closely related to the sinus. These findings may serve as reference information for root canal treatment, tooth extraction, dental implant, and other dental clinical procedures among patients in western China.
A retrospective observational study of sarcopenia and outcomes in critically ill patients
Authors: Joyce Patrick R , O’Dempsey Ryan , Kisby Giles , Anstey Christopher 
Published: June 2020

Frailty assessment in patients admitted to intensive care is often limited using traditional clinical frailty assessment tools. Opportunistic use of contemporary computed tomography (CT) can provide an objective estimate of low skeletal muscle mass (sarcopenia) as a proxy for frailty. The aim of this study was to establish the prevalence of sarcopenia in an Australian intensive care unit (ICU) population and to examine the relationship between sarcopenia and clinical outcomes. We undertook a single centre retrospective study of 1085 adult patients admitted to a single ICU over 12 months. Patients with a contemporary CT scan including the L3 vertebral body were included. Patients were categorised as sarcopenic or non-sarcopenic using previously published data. A total of 279 patients with a mean age of 67 years had an eligible CT scan; 163 (58%) were male. Higher 30-day mortality was associated with the use of CRRT (continuous renal replacement therapy) during the ICU admission (OR 6.84, P < 0.001) and also associated with lower cross-sectional muscle area (odds ratio (OR) 0.98, P = 0.004). Sarcopenia was found to be highly prevalent in this particular Australian ICU population (68%) and associated with older age (68 versus 55 years, P < 0.001), lower body mass index (27 versus 32 kg m−2, P < 0.001), more comorbidities (3 versus 2, P = 0.009), and longer stays in hospital (279 versus 223 h, P = 0.043). As a continuous predictor, lumbar muscle mass was associated with 30-day mortality with and without adjusting for other covariates.
The first case of fungal endogenous endophthalmitis caused by Aspergillus nidulans: Diagnostic and therapeutic challenge
Authors: Mata-Moret Lucia , Monferrer-Adsuara Clara , Hernández-Bel Laura , Hernández-Garfella Marisa , Torrecillas-Muelas Miriam , Ocete-Mochón Maria Dolores , Cervera-Taulet Enrique 
Published: June 2020

Significance: Fungal endogenous endophthalmitis is an uncommon and potentially blinding infection. Aspergillus is a causative organism in immunocompromized although is virulent enough to afflict immunocompetents. Their propensity to affect macula usually results in a dismal prognosis; thus, improving visual outcome has always been challenging to clinicians. A. nidulans has only rarely been implicated in exogenous endophthalmitis. Purpose: To report the first case of A. nidulans endogenous endophthalmitis. Case report: An asthmatic 42-year-old female presented with sudden unilateral vision loss due to a submacular abscess that progressively worsened in a matter of days. Vitreous PCR analysis after an urgent vitrectomy was positive for A. nidulans with no active systemic foci found. Oral and intravitreal Voriconazole was prescribed but multiple reactivations led to three vitrectomies in total alongside with subretinal Voriconazole, abscess aspiration, and endolaser. There was complete resolution of the infection and, although visual acuity was poor due to macular scar, enucleation was avoided. Conclusion: Although uncommon, we must consider Aspergillus as the causative organism in apparently immunocompetent patients with history of recent systemic corticosteroids treatment, especially if they suffer a broncopulmonary disorder. Aspergillus is an aggressive organism so a high index of suspicion along with early diagnosis and prompt treatment is the key for better outcomes. We highlight A. nidulans as the causative agent as there are no other reported cases.
Standard versus mini-percutaneous nephrolithotomy for renal stones: a meta-analysis
Authors: Deng Jun , Li Jin , Wang Longwang , Hong Yanyan , Zheng Liangliang , Hu Jieping , Kuang Renrui 
Published: June 2020

Objectives: To compare the standard percutaneous nephrolithotomy and mini-percutaneous nephrolithotomy in order to determine the optimal tract size for patients with renal stones. Methods: A systematic search of Web of Science, EMBASE, Cochrane Library, and PubMed databases was conducted for articles published through 20 August 2019, reporting on a comparison of the standard percutaneous nephrolithotomy and mini-percutaneous nephrolithotomy using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results: Of 763 studies, 14 were considered for the evidence synthesis. A total of 1980 cases were included. Of these patients, 897 cases underwent standard percutaneous nephrolithotomy, and 1083 cases underwent mini-percutaneous nephrolithotomy. Stone-free rates were 87.6% (786 of 897 patients) for standard percutaneous nephrolithotomy and 87.8% (951 of 1083 patients) for mini-percutaneous nephrolithotomy ( p = 0.57). Tract sizes of 30F and 22–26F in standard percutaneous nephrolithotomy group shorten operation time compared with mini-percutaneous nephrolithotomy ( p = 0.02; p = 0.004; respectively). Leakage ( p = 0.04), bleeding ( p = 0.01), blood transfusion ( p < 0.00001), and renal pelvis perforation ( p = 0.02) were more common in standard percutaneous nephrolithotomy group than in mini-percutaneous nephrolithotomy group. Subgroup analysis showed only blood transfusion for 30F and 22–26F standard percutaneous nephrolithotomy group was more common than mini-percutaneous nephrolithotomy ( p < 0.0001, p = 0.005, respectively). Conclusions: Standard percutaneous nephrolithotomy was associated with higher leakage, bleeding, blood transfusion, and renal pelvis perforation, but had a shorter operation time. Tract size of 30F improved the stone-free rate compared with mini-percutaneous nephrolithotomy, but led to more complications. Tract size of 22–26F was no better than 30F or mini-percutaneous nephrolithotomy.
Physicians’ and nurses’ decision making to encounter neonates with poor prognosis in the neonatal intensive care unit
Authors: Rafiee Zahra , Rabiee Maryam , Rafati Shiva , Rejeh Nahid , Borna Hajieh , Vaismoradi Mojtaba 
Published: June 2020

Background Decision making regarding the treatment of neonates with poor prognoses is difficult for healthcare staff working in the neonatal intensive care unit (NICU). This study aimed to investigate the attitudes of physicians and nurses about the value of life and ethical decision making when encountering neonates with poor prognosis in the NICU. Methods This cross-sectional study was conducted in five NICUs of five hospitals in Tehran city, Iran. The attitudes of 144 pediatricians, gynecologists and nurses were assessed using the questionnaire of attitude toward the value of life and agreement on intensive care management based on three hypothetical case scenarios of neonates with poor prognosis. Data were analyzed using descriptive and inferential statistics via the SPSS software. Results The negative agreement on the no initiation of intensive care measures and the discontinuation of resuscitation in neonates with poor prognosis was more than the positive agreement. Also, various factors influenced the participants’ decision making for the provision of care to neonates. Regarding the case scenarios, the participants agreed on the provision of aggressive, conservative, and palliative care with various frequencies. This study confirms the importance of healthcare providers’ perspectives and their impacts on ethical decision making. The participants favored the value or sacredness of life and agreed on the use of all therapeutic measures for saving the lives of neonates with poor prognosis. Conclusion More studies are required to improve our understandings of factors influencing ethical decision making by healthcare providers when encountering neonates with poor prognosis in NICUs.
Histone deacetylase-3: Friend and foe of the brain
Authors: D’Mello Santosh R 
Published: June 2020

Histone deacetylases (HDACs) are a family of enzymes that deacetylate histones as well as a large number of other nuclear, cytoplasmic, and mitochondrial proteins. The deacetylation of histones transforms chromatin to a transcriptionally repressed state, whereas deacetylation of other cellular proteins regulates their functional activity through modulation of subcellular location, their interaction with other proteins, and in the case of transcription factors, their DNA-binding ability. A compelling body of evidence derived from the utilization of pharmacological inhibitors indicates that histone deacetylases are important regulators of brain development as well as the pathogenesis of neurodegenerative diseases. However, because most of the pharmacological inhibitors used are non-selective with regard to the different members of the HDAC family, the significance of individual HDAC proteins to brain development and degeneration has been difficult to delineate. This review focuses on HDAC3. Experiments conducted using more recently developed isoform selective inhibitors and molecular genetic approaches demonstrate that HDAC3 regulates different steps of neurodevelopment, including neurogenesis, gliogenesis, glial cell fate determination, and the myelination of oligodendrocytes and Schwann cells. However, specific posttranslational modifications and alterations in its binding partners transform HDAC3 from a protein that is beneficial to the brain to one that is neurotoxic. The role of HDAC3 in the promotion of neurodegeneration and the inhibition of recovery after nerve injury is reviewed. The role of HDAC3 in the regulation of memory in the adult and aging brain is also described. Impact statement Brain development and degeneration are highly complex processes that are regulated by a large number of molecules and signaling pathways the identities of which are being unraveled. Accumulating evidence points to histone deacetylases and epigenetic mechanisms as being important regulators of these processes. In this review, we describe that histone deacetylase-3 (HDAC3) is a particularly crucial regulator of both neurodevelopment and neurodegeneration. In addition, HDAC3 regulates memory formation, synaptic plasticity, and the cognitive impairment associated with normal aging. Understanding how HDAC3 functions contributes to the normal development and functioning of the brain while also promoting neurodegeneration could lead to the development of therapeutic approaches for neurodevelopmental, neuropsychiatric, and neurodegenerative disorders.
MiR-664 Protects Against UVB Radiation-Induced HaCaT Cell Damage via Downregulating ARMC8
Authors: Zhang Chen , Xie Xiongxiong , Yuan Yawen , Wang Yimeng , Zhou Meijuan , Li Xiangzhi , Zhen Peilin 
Published: June 2020

Background: MiR-664 has been demonstrated to play an important role in dermal diseases. However, the functions of miR-664 in ultraviolet B (UVB) radiation-induced keratinocytes damage remain to be elucidated. Objective: The present study aimed to investigate the molecular mechanisms under the UVB-induced keratinocytes damage and provide translational insights for future therapeutics and UVB protection. Methods: HaCaT cells were transfected with miR-664, either alone or combined with UVB irradiation. Levels of messenger RNA and protein were tested by quantitative real-time polymerase chain reaction and Western blot analyses. Cell proliferation, percentage of apoptotic cells, and expression levels of apoptosis-related factors were measured by Cell Counting Kit-8 assay, flow cytometry assay, and Western blot analysis, respectively. Results: We found that a significant increase in miR-664 was observed in UVB-induced HaCaT cells. Overexpressed miR-664 promoted cell vitalities and suppressed apoptosis of UVB-induced HaCaT cells. Additionally, the loss/gain of armadillo-repeat-containing protein 8 (ARMC8) rescued/blocked the effects of miR-664 on the proliferation of UVB-induced HaCaT cells. Conclusions: Our data demonstrate that miR-664 functions as a protective regulator in UVB-induced HaCaT cells via regulating ARMC8.
High-sensitivity C-reactive protein is associated with clonal hematopoiesis of indeterminate potential
Authors: Busque Lambert , Sun Maxine , Buscarlet Manuel , Ayachi Sami , Feroz Zada Yassamin , Provost Sylvie , Bourgoin Vincent , Mollica Luigina , Meisel Marlies , Hinterleitner Reinhard , Jabri Bana , Dubé Marie-Pierre , Tardif Jean-Claude 
Published: June 2020

AbstractClonal hematopoiesis of indeterminate potential (CHIP) is predictive of hematological cancers and cardiovascular diseases, but the etiology of CHIP initiation and clonal expansion is unknown. Several lines of evidence suggest that proinflammatory cytokines may favor mutated hematopoietic stem cell expansion. To investigate the potential link between inflammation and CHIP, we performed targeted deep sequencing of 11 genes previously implicated in CHIP in 1887 subjects aged &gt;70 years from the Montreal Heart Institute Biobank, of which 1359 had prior coronary artery disease (CAD), and 528 controls did not. We assessed association of CHIP with log transformed high-sensitivity C-reactive protein (hs-CRP), a validated biomarker of inflammation. CHIP was identified in 427 of the 1887 subjects (22.6%). CHIP mutations were more frequently identified in DNMT3A (11.6%) and TET2 (6.1%), with a higher proportion of TET2 mutations occurring in controls than in patients with CAD (9.0% vs 4.9%, P &lt; .001). CHIP carriers had 21% higher hs-CRP levels compared with their noncarrier counterparts (eβ = 1.21, 95% confidence interval [CI]: 1.08 to 1.36; P = .001). A similar effect was observed in the subgroup of patients with known CAD (eβ = 1.22, 95% CI: 1.06 to 1.41; P = .005). These findings confirm the association between inflammation and CHIP. This association may open investigational avenues aimed at documenting mechanisms linking inflammation to clonal progression and ultimately supports prevention interventions to attenuate CHIP’s impact on cardiovascular disease and cancer.
New insights into risk factors for transplant-associated thrombotic microangiopathy in pediatric HSCT
Authors: Elfeky Reem , Lucchini Giovanna , Lum Su-Han , Ottaviano Giorgio , Builes Natalia , Nademi Zohreh , Battersby Alexandra , Flood Terence , Owens Stephen , Cant Andrew J. , Young Helen , Greener Sinéad , Walsh Patrick , Kavanagh David , Annavarapu Srinivas , Rao Kanchan , Amrolia Persis , Chiesa Robert , Worth Austen , Booth Claire , Skinner Roderick , Doncheva Bilyana , Standing Joseph , Gennery Andrew R. , Qasim Waseem , Slatter Mary , Veys Paul 
Published: June 2020

Abstract
This study aimed to identify a risk profile for development of transplant-associated thrombotic microangiopathy (TA-TMA) in children undergoing hematopoietic stem cell transplantation (HSCT). Between 2013 and 2016, 439 children underwent 474 HSCTs at 2 supraregional United Kingdom centers. At a median of 153 days post-HSCT, TA-TMA occurred among 25 of 441 evaluable cases (5.6%) with no evidence of center variation. Sex, underlying disease, intensity of the conditioning, total body irradiation–based conditioning, the use of calcineurin inhibitors, venoocclusive disease, and viral reactivation did not influence the development of TA-TMA. Donor type: matched sibling donor/matched family donor vs matched unrelated donor vs mismatched unrelated donor/haplo-HSCT, showed a trend toward the development of TA-TMA in 1.8% vs 6.1% vs 8.3%, respectively. Presence of active comorbidity was associated with an increased risk for TA-TMA; 13% vs 3.7% in the absence of comorbidity. The risk of TA-TMA was threefold higher among patients who received &gt;1 transplant. TA-TMA rates were significantly higher among patients with acute graft-versus-host disease (aGVHD) grades III to IV vs aGVHD grade 0 to II. On multivariate analysis, the presence of active comorbidity, &gt;1 transplant, aGVHD grade III to IV were risk factors for TA-TMA (odds ratio [OR]: 5.1, 5.2, and 26.9; respectively), whereas the use of cyclosporine A/tacrolimus-based GVHD prophylaxis was not a risk factor for TA-TMA (OR: 0.3). Active comorbidity, subsequent transplant, and aGVHD grades III to IV were significant risk factors for TA-TMA. TA-TMA might represent a form of a vascular GVHD, and therefore, continuing control of aGVHD is important to prevent worsening of TA-TMA associated with GVHD.