bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results of the non-small cell lung cancer part of a phase III, open-label, randomized trial evaluating topical corticosteroid therapy for facial acneiform dermatitis induced by EGFR inhibitors: stepwise rank down from potent corticosteroid (FAEISS study, NCCH-1512)
Authors: Nishino Kazumi , Fujiwara Yutaka , Ohe Yuichiro , Saito Ryota , Miyauchi Eisaku , Kobayashi Tetsu , Nakai Yasuo , Takahashi Toshiaki , Shibata Taro , Hamaguchi Tetsuya , Kikuchi Katsuko , Yamazaki Naoya , Fukuda Haruhiko , Nozawa Keiko , Kiyohara Yoshio 
Published: September 2020

Abstract
Purpose
This FAEISS study was designed to confirm the superior efficacy of reactive topical corticosteroid strategies employing serially ranking-DOWN from very strong steroid levels for the treatment of facial acneiform rash induced by epidermal growth factor receptor (EGFR) inhibitors (EGFRIs), in comparison with strategies employing serially ranking-UP from weak steroid levels. This article reports the primary results of the non-small cell lung cancer (NSCLC) part of the trial.

Methods
Patients with EGFR-mutated advanced NSCLC treated with erlotinib or afatinib were enrolled in the first registration. All patients received preemptive therapy with oral minocycline and heparinoid moisturizer from the initiation of an EGFR inhibitor. Enrolled patients who developed facial acneiform rash within 2 weeks were randomized at second registration to either a ranking-UP (WEAK) group or a ranking-DOWN group. The primary endpoint was incidence of grade ≥ 2 facial acneiform rash over 8 weeks.

Results
Fifty-one patients were enrolled at the first registration and received EGFRIs (n = 30 for afatinib, n = 21 for erlotinib). However, 35 patients did not develop facial acneiform rash within 2 weeks; one patient discontinued preemptive treatment. Fifteen patients (29.4%) were enrolled in the second registration; nine were assigned to the WEAK group and six to the DOWN group. There was no significant difference in the incidence of grade ≥ 2 facial acneiform rash between the WEAK group (one patient, twice) and the DOWN group (one patient, twice; p = 0.8417). No patients developed severe facial acneiform rash within 10 weeks.

Conclusion
In NSCLC patients who received EGFRIs, preemptive therapy of oral minocycline and heparinoid moisturizer reduced facial acneiform rash incidence.

Trial registration
UMIN000024113
Variation in timing of breeding of five woodpeckers in a primeval forest over 45 years: role of food, weather, and climate
Authors: Wesołowski Tomasz , Hebda Grzegorz , Rowiński Patryk 
Published: September 2020

AbstractClimate warming could lead to ‘mis-matching’ of birds’ breeding times with availability of their invertebrate food resources. Fluctuating spring temperatures could influence variation in the commencement of egg-laying, as well as, in phenology of their resources (e.g., tree bud burst, appearance of folivorous caterpillars). We studied timing of Dendrocopos leucotos, Dendrocoptes medius, Dendrocopos major, Dryobates minor, and Picoides tridactylus breeding in, free of direct human intervention, strictly protected fragments of Białowieża Forest (Poland) in 1975–2019. We related their onset of breeding to inter-year variation in spring weather, trees’ bud burst and timing of folivorous caterpillars’ availability. Individual species initiated breeding at dates differing by a month. In spite of intraseasonal differences in the absolute laying dates, sometimes exceeding three weeks, the sequence of laying by different species within a season was highly repeatable; D. leucotos commenced the first and P. tridactylus the last. Within a species and season, the females commenced laying synchronously; usually 50% of them begun laying ≤ 8 days of each other. All species bred earlier when spring temperatures got higher. Nestling time of D. medius and D. major broadly coincided with ‘caterpillar peaks’, while D. minor young appeared too late. All woodpeckers advanced egg-laying in Białowieża National Park over 45 years but the inter-specific sequence of laying has been retained. These could be responses to strong advance of snow disappearance and to warming of the second half of April. The early recent laying dates remained within the range of earlier recorded ones, the early springs just became more frequent. Thus, the phenological acclimatization could be achieved by plastic behavioural and physiological adjustments. Lack of data on types of food actually used and their seasonal variation hinders mechanistic understanding of how warming would affect the future food supply and breeding performance of birds.
Klimaschutzverfassungsrecht: Klima-Staatszielbestimmungen im Föderalismus
Authors: Härtel Ines 
Published: September 2020

ZusammenfassungKlimaschutz wird zunehmend Aufgabe des Verfassungsrechts in föderaler Gestaltung. Kontrovers
ist dabei die Aufnahme einer Klima-Staatszielbestimmung. Welche Wirkungen ergeben sich für Grundrechte,
welcher Mehrwert entsteht gegenüber der aktuellen Rechtslage? Welche Problematik birgt der “Klimavorrang”
– gerade in Bezug auf Schutzgüterkonflikte? Hier ist auch der Blick auf die Entwicklung des
Verfassungsrechts anderer Staaten aufschlussreich.
Stable roommates with narcissistic, single-peaked, and single-crossing preferences
Authors: Bredereck Robert , Chen Jiehua , Finnendahl Ugo Paavo , Niedermeier Rolf 
Published: September 2020

AbstractThe classicalStable Roommatesproblem is to decide whether there exists a matching of an even number of agents such that no two agents which are not matched to each other would prefer to be with each other rather than with their respectively assigned partners. We investigateStable Roommateswith complete (i.e., every agent can be matched with any other agent) or incomplete preferences, with ties (i.e., two agents are considered of equal value to some agent) or without ties. It is known that in general allowing ties makes the problem NP-complete. We provide algorithms forStable Roommatesthat are, compared to those in the literature, more efficient when the input preferences are complete and have some structural property, such as being narcissistic, single-peaked, and single-crossing. However, when the preferences are incomplete and have ties, we show that being single-peaked and single-crossing does not reduce the computational complexity—Stable Roommatesremains NP-complete.
Assessing uncertainties in the regional projections of precipitation in CORDEX-AFRICA
Authors: Bichet Adeline , Diedhiou Arona , Hingray Benoit , Evin Guillaume , Touré N’Datchoh Evelyne , Browne Klutse Nana Ama , Kouadio Kouakou 
Published: September 2020

AbstractOver the past decades, large variations of precipitation were observed in Africa, which often led to dramatic consequences for local society and economy. To avoid such disasters in the future, it is crucial to better anticipate the expected changes, especially in the current context of climate change and population growth. To this date, however, projections of precipitation over Africa are still associated with very large uncertainties. To better understand how this uncertainty can be reduced, this study uses an advanced Bayesian analysis of variance (ANOVA) method to characterize, for the first time in the regional climate projections of CORDEX-AFRICA, the different sources of uncertainty associated with the projections of precipitation over Africa.By 2090, the ensemble mean precipitation is projected to increase over the Horn of Africa from September to May and over the eastern Sahel and Guinea Coast from June to November. It is projected to decrease over the northern coast and southern Africa all year long, over western Sahel from March to August, and over the Sahel and Guinea Coast from March to May. Most of these projections however are not robust, i.e., the magnitude of change is smaller than the associated uncertainty. Over time, the relative contribution of internal variability (excluding interannual variability) to total uncertainty is moderate and quickly falls below 10%. By 2090, it is found that over the Horn of Africa, northern coast, southern Africa, and Sahel, most of the uncertainty results from a large dispersion across the driving Global Climate Models (in particular MIROC, CSIRO, CCCma, and IPSL), whereas over the tropics and parts of eastern Africa, most of the uncertainty results from a large dispersion across Regional Climate Models (in particular CLMcom).
Problem-posing triggers or where do mathematics competition problems come from?
Authors: Kontorovich Igor’ 
Published: September 2020

AbstractSpurred by Kilpatrick’s (1987) “Where do good problems come from?”, this study explores problem-posing triggers of experienced problem posers for mathematics competitions. Triggers are conceived as instances of noticing, where an impulse draws a poser’s attention and “triggers off” a mathematical re-action, one of the outcomes of which is a creation of a problem that gets accepted to some mathematics competition. The data were collected from 26 problem posers residing in nine countries, and who had experience in creating problems for national, regional, and international competitions. Three types of triggers emerged from the analysis: (i) Instances where the participants extracted mathematical phenomena from activities that are replete with modern elementary mathematics. These triggers were described in emotionally loaded terms that resonated with appreciation, surprise, challenge, and feeling of innovation. (ii) Cases where the participants abstracted mathematical phenomena from common everyday-life tasks in which mathematical optimization was beneficial. These situations emphasized participants’ desire to compensate for self-disappointment with an initially made decision and the value of finding a better alternative. (iii) Situations where the participants were asked to pose a problem ‘here and now’. The posers were unanimous in their dislike of such situations. They elaborated on how difficult it is to pose ‘here and now’ and highlighted the low quality of the resulting problems. The findings are situated in the body of knowledge on expert problem posing and educational literature on school students and teachers.
Are Mental Health, Family and Childhood Adversity, Substance Use and Conduct Problems Risk Factors for Offending in Autism?
Authors: Payne Katy-Louise , Maras K. L. , Russell A. J. , Brosnan M. J. 
Published: September 2020

AbstractMental health difficulties, family and childhood adversity factors, substance use and conduct problems have all been linked to offending behaviour in the general population. However, no large-scale study with comparison groups has investigated these risk factors in relation to autistic offenders. The current research included 40 autistic offenders, 40 autistic non-offenders, 40 typically developed (TD) offenders and 39 TD non-offenders. Conduct problems risk factors differentiated autistic offenders from both non-offender groups (autistic and TD) and mental health risk factors differentiated autistic offenders from both TD groups (offenders and non-offenders). Further research is required to understand more about the role of both conduct problems risk factors in autistic offenders (e.g., age at onset, frequency of behaviours) and the mental health needs of autistic offenders.
Sorption behavior and hydroxyl accessibility of wood treated with different cyclic N-methylol compounds
Authors: Emmerich Lukas , Altgen Michael , Rautkari Lauri , Militz Holger 
Published: September 2020

AbstractCyclic N-methylol compounds such as 1,3-dimethylol-4,5-dihydroxyethyleneurea (DMDHEU) have been used to modify wood and prevent negative effects related to the uptake of moisture. However, the changes in the sorption behavior of wood by treatments with DMDHEU and its derivatives are not fully understood. In the present study, wood blocks were treated with DMDHEU, ether-modified DMDHEU and diethyleneglycolated DMDHEU in order to study the factors that control the changes in moisture uptake in the hygroscopic range (0–95% RH). Dimensional changes of wood blocks during water soaking cycles suggested that the treatments caused a permanent cell wall bulking, whereas the swelling restraint by cross-linking of adjacent cell wall polymers was not permanent. However, the changes in water vapor sorption were not only a result of the cell wall bulking effect that reduced the space in the cell wall to accommodate water. The N-methylol compounds within the wood also provided additional sorption sites, but there was no correlation between absorbed water and accessible OH groups. It was speculated that the co-condensation of the N-methylol compounds with wood polymers had a significant effect on the sorption of the treated wood. At elevated RH, pure resins that were formed by self-condensation took up large quantities of moisture. However, when the N-methylol compounds were heat-cured within the hierarchical structure of wood, the moisture uptake of the treated wood at elevated RH was even lower compared to unmodified wood. Furthermore, the covalent bond formation between wood and resin prolonged the attainment of an equilibrium moisture content.
On the nonsmooth dynamics of towed wheels
Authors: Antali Mate , Stepan Gabor 
Published: September 2020

AbstractIn this paper, a nonsmooth model of towed wheels is analysed; this mechanism can be a part of different kind of vehicles. We focus on the transitions between slipping and rolling in the presence of dry friction. The model leads to a three-dimensional dynamical system with a codimension-2 discontinuity. The systems can be analysed by means of the tools of extended Filippov systems. The essence of the calculation is to find the so-called limit directions, which show the possible directions of slipping-rolling transitions and their properties. By this method, four different scenarios are found. The results are compared to those from the creep models.
Phylogenetic analysis of plant multi-domain SEC14-like phosphatidylinositol transfer proteins and structure–function properties of PATELLIN2
Authors: Montag Karolin , Hornbergs Jannik , Ivanov Rumen , Bauer Petra 
Published: September 2020

Abstract
Key message
SEC14L-PITPs guide membrane recognition and signaling. An increasingly complex modular structure of SEC14L-PITPs evolved in land plants compared to green algae. SEC14/CRAL-TRIO and GOLD domains govern membrane binding specificity.

Abstract
SEC14-like phosphatidylinositol transfer proteins (SEC14L-PITPs) provide cues for membrane identity by exchanging lipophilic substrates, ultimately governing membrane signaling. Flowering plant SEC14L-PITPs often have modular structure and are associated with cell division, development, and stress responses. Yet, structure–function relationships for biochemical–cellular interactions of SEC14L-PITPs are rather enigmatic. Here, we evaluate the phylogenetic relationships of the SEC14L-PITP superfamily in the green lineage. Compared to green algae, land plants have an extended set of SEC14L-PITPs with increasingly complex modular structure. SEC14-GOLD PITPs, present in land plants but not Chara, diverged to three functional subgroups, represented by the six PATELLIN (PATL) proteins in Arabidopsis. Based on the example of Arabidopsis PATL2, we dissect the functional domains for in vitro binding to phosphoinositides and liposomes and for plant cell membrane association. While the SEC14 domain and its CRAL-TRIO-N-terminal extension serve general membrane attachment of the protein, the C-terminal GOLD domain directs it to the plasma membrane by recognizing specific phosphoinositides. We discuss that the different domains of SEC14L-PITPs integrate developmental and environmental signals to control SEC14L-PITP-mediated membrane identity, important to initiate dynamic membrane events.
Impact of air pollution exposure during various periods of pregnancy on term birth weight: a large-sample, retrospective population-based cohort study
Authors: Shang Li , Huang Liyan , Yang Liren , Leng Longtao , Qi Cuifang , Xie Guilan , Wang Ruiqi , Guo Leqian , Yang Wenfang , Chung Mei Chun 
Published: September 2020

AbstractPrevious studies have suggested that maternal exposure to air pollution might affect term birth weight. However, the conclusions are controversial. Birth data of all term newborns born in Xi’an city of Shaanxi, China, from 2015 to 2018 and whose mother lived in Xi’an during pregnancy were selected form the Birth Registry Database. And the daily air quality data of Xi’an city was collected from Chinese Air Quality Online Monitoring and Analysis Platform. Generalized additive models (GAM) and 2-level binary logistic regression models were used to estimate the effects of air pollution exposure on term birth weight, the risk term low birth weight (TLBW), and macrosomia. Finally, 321521 term newborns were selected, including 4369(1.36%) TLBW infants and 24,960 (7.76%) macrosomia. The average pollution levels of PM2.5, PM10, and NO2 in Xi’an city from 2015 to 2018 were higher than national limits. During the whole pregnancy, maternal exposure to PM2.5, PM10, SO2, and CO all significantly reduced the term birth weight and increased the risk of TLBW. However, NO2 and O3 exposure have significantly increased the term birth weight, and O3 even increased the risk of macrosomia significantly. Those effects were also observed in the first and second trimesters of pregnancy. But during the third trimester, high level of air quality index (AQI) and maternal exposure to PM2.5, PM10, SO2, NO2, and CO increased the term birth weight and the risk of macrosomia, while O3 exposure was contrary to this effect. The findings suggested that prenatal exposure to air pollution might cause adverse impacts on term birth weight, and the effects varied with trimesters and pollutants, which provides further pieces of evidence for the adverse effects of air pollution exposure in heavy polluted-area on term birth weight.
An investigation on the efficiency of low-cost adsorbents in removing uranium from water samples
Authors: Police Sandeep , Maity Sukanta , Chaudhary Dilip Kumar , Sahu Sanjay Kumar , Vinod Kumar A. 
Published: September 2020

AbstractThe groundwater samples were found to be contaminated with high concentrations of uranium (U) in Punjab state as well as in few other locations of India. U being chemically toxic can deteriorate health when ingested. Hence, there is a need to remove U from contaminated water using an efficient, cheap and user friendly method. A study was initiated to investigate the efficiency of low-cost adsorbents in removing U from water. Seven adsorbents were screened for U removal efficiency, among which fly ash (FA) and tea waste (TW) were found to have better removal efficiency. Solid–liquid contact time and solution pH were optimized to establish conditions for better U removal efficiency. The U adsorption on FA and TW followed pseudo-second-order kinetics with rate constant values 4.63 g/mg/min and 15.63 g/mg/min, respectively. FA and TW had the highest U removal capability at pH 6 and pH 4, respectively. The U sorption data were fitted with Freundlich and Dubinin–Radushkevich isotherm models. The U adsorption on FA and TW is found to be a physical process with mean free energy (E) values less than 8 kJ/mol. Theoretically calculated maximum adsorption capacity values indicate that FA is a better adsorbent as compared to TW, which has been further confirmed experimentally. The U adsorption on both the adsorbents has interference from Ca2+ and no interference from Fe3+ at tested U concentrations. It is also found that FA and TW are effective in decontaminating U from spiked real groundwater samples to below the WHO (Guidelines for drinking water quality, 4th ed, vol 1, World Health Organization, Geneva, 2011) limit.
Parametric study to enhance performance of wastewater treatment process, by reverse osmosis-photovoltaic system
Authors: Jbari Yousra , Abderafi Souad 
Published: September 2020

AbstractThe presence of certain toxic pollutants in water and wastewater such as chlorophenol must be eliminated, as they have negative effects on human health and the environment. Based on the state of the art, the reverse osmosis (RO) coupled with photovoltaic (PV) was chosen for wastewater treatment. The aim of this article is to evaluate the optimal operating conditions of RO-PV system that maximize chlorophenol rejection with minimal energy consumption. Two complementary approaches were followed combining physical models with statistical ones. The physical model used for the simulation is based on the equations of diffusion and matter balance. After demonstrating the reliability of this model, it was used for parametric sensitivity analysis, performing numerical experiments using a program developed under Python. The data obtained were used for operating parameters optimization, using artificial neural network method coupled with the desirability function. The results showed that the optimal values obtained, relating to feed pressure of 9.713 atm, water recovery rate of 40%, operating flow rate of 10−4 m3/s and temperature of 40 °C could remove 91% of chlorophenol with an energy consumption of 0.8 kWh/m3. This consumption allowed us to deduce that photovoltaic solar panel with a peak power of 280 Wp and a battery capacity of 9.22 kWh is sufficient to produce 1 m3/day.
Social influence and unfollowing accelerate the emergence of echo chambers
Authors: Sasahara Kazutoshi , Chen Wen , Peng Hao , Ciampaglia Giovanni Luca , Flammini Alessandro , Menczer Filippo 
Published: September 2020

AbstractWhile social media make it easy to connect with and access information from anyone, they also facilitate basic influence and unfriending mechanisms that may lead to segregated and polarized clusters known as “echo chambers.” Here we study the conditions in which such echo chambers emerge by introducing a simple model of information sharing in online social networks with the two ingredients of influence and unfriending. Users can change both their opinions and social connections based on the information to which they are exposed through sharing. The model dynamics show that even with minimal amounts of influence and unfriending, the social network rapidly devolves into segregated, homogeneous communities. These predictions are consistent with empirical data from Twitter. Although our findings suggest that echo chambers are somewhat inevitable given the mechanisms at play in online social media, they also provide insights into possible mitigation strategies.