bluuebunny/crossref_metadata_2025_split huggingface dataset:
PSIII-17 Nutritional value of high-lysine sorghum, red sorghum, white sorghum, and corn fed to growing pigs
Authors: Espinosa Charmaine D , Thomas Lori L , Goodband Robert D , Stein Hans H 
Published: July 2020

Abstract
Two experiments were conducted to test the hypothesis that the standardized total tract digestibility (STTD) of P and digestible energy (DE) and metabolizable energy (ME) in a new variety of high-lysine sorghum is not different from values obtained in conventional sorghum varieties or in corn. In experiment 1, 48 barrows (18.63 ± 0.89 kg) were housed individually in metabolism crates and randomly allotted to 1 of 8 diets. Diets were based on high-lysine sorghum, red sorghum, white sorghum, or corn as the sole source of P and these diets either contained no microbial phytase or 500 units/kg of phytase. Feces were collected using the marker to marker approach with 5-d adaptation and 4-d collection periods. Data were analyzed by ANOVA using the Mixed Procedure of SAS. Results indicated that phytase supplementation improved (P ≤ 0.05) STTD of P in all ingredients, but the STTD of P in high-lysine sorghum was not different from the STTD of P in other grains (Table 1). In experiment 2, 32 barrows (18.54 ± 0.77 kg) were housed individually in metabolism crates and randomly allotted to 1 of 4 diets. Diets contained high-lysine sorghum, red sorghum, white sorghum, or corn as the only energy-containing ingredient. Feces and urine samples were collected using the marker to marker approach with 5-d adaptation and 4-d collection periods. Data were analyzed as explained for Exp. 1. The ATTD of gross energy in high-lysine sorghum was less (P ≤ 0.05) than in corn, but the DE and ME in high-lysine sorghum was not different from corn. In conclusion, supplementation of phytase improved STTD of P in cereal grains, and values for STTD of P, as well as for DE and ME in high-lysine sorghum, were not different from corn, which indicates that high-lysine sorghum can replace corn in swine diets.
PSVII-15 The effects of feeding a fortified protein blend as a replacement for animal and fish proteins in nursery pig diets
Authors: Palencia Jorge Y P , Chastain Clayton S , Duttlinger Alan W , Mills Kayla M , Feldpausch Julie A , Jones Dan B , Asmus Matthew D , Richert Brian T 
Published: July 2020

Abstract
The objective of this study was to evaluate the effects of total or partial replacement of animal and fish proteins with a fortified protein blend (PROPLEX MVP) on growth performance of nursery piglets. PROPLEX MVP is a blend of two distinct fermentation biomass streams, refined soybean products, select amino acids, and a NSP enzyme complex. A total of 306 barrows and gilts [(Duroc x (Landrace x Yorkshire), avg. 22 d age and BW 6.37 ± 1.24 kg)] were used in a randomized complete block design with three dietary treatments, each with 19 replicates (pens) of 5 piglets. Dietary treatments were: 1) Control diet (CONT) with animal and fish protein sources (Blood meal, Spray-dried Plasma, and Fish meal); 2) PROPLEX MVP (MVP): CONT with MVP replacing Fish meal; 3) PROPLEX MVP 100 (MVP100): CONT with MVP replacing 100% of animal and fish proteins. Pigs were fed a budgeted amount per head of the assigned experimental diets for the first three feeding phases (Phase 1: 2.3 kg/pig; Phase 2: 4.5 kg/pig; Phase 3: 6.8 kg/pig). A common diet was provided in Phase 4 until day 42 post-weaning. Pigs fed CONT had greater ADG (P &lt; 0.05) compared to MVP100 pigs d 0-7 post-weaning. From d 7 to 14, pigs fed MVP and MVP100 had a significantly greater ADG and G:F (P &lt; 0.05) than pigs fed CONT diet. For the remainder of the experimental period (d 14 to 42), no differences (P &gt; 0.10) were observed among treatments. The use of MVP100 reduced (P &lt; 0.05) the total nursery feed cost by US $1.03/pig and feed cost/kg of weight gain by 12%. In conclusion, MVP protein blend can effectively substitute for animal and fish proteins sources without compromising overall nursery pigs’ growth performance and results in significant feed cost savings.
The Association of Mammography Environment and Image Quality
Authors: Sarquis-Kolber Shakira , Schilling Kathy , Hanney William J , Kolber Morey J 
Published: July 2020

Abstract

Objective
This study sought to determine if a mammogram performed in a multi-sensory environmental upgraded room (UR) is associated with improved image quality when compared to a standard room (SR).

Methods
A retrospective analysis (interrupted time series design) of compression force and posterior nipple line (PNL) measurements was performed on 303 women (mean age 60.9 years) who underwent screening mammography for 2 consecutive years (year 1 in SR, year 2 in UR) at a single outpatient facility. Using the Picture Archiving Communication System (PACS), craniocaudal (CC) and mediolateral oblique (MLO) images for the two years were reviewed. The PNL was measured for the CC and MLO images bilaterally using the embedded tools in the PACS software. Posterior nipple line and compression force were analyzed using a paired t-test. Bland–Altman plots were used to obtain 95% limits of agreement (LOA) between the UR and SR.

Results
Image quality as determined by PNL measurement distance was greater in the UR (P &lt; 0.001) when compared with the SR, with similar compression force (P ≥ 0.14). Mean PNL measurement differences ranged from 5.0 to 6.2 mm greater in the UR, whereas mean compression force differences ranged from -2.4 to 1.5 newtons. The 95% LOA suggest that PNL measurement differences between the UR and SR can vary by -11.0 to 27.0 mm.

Conclusion
Environmentally modifying mammography rooms may improve image quality with regard to PNL measurements without increasing compression force.
Synergisms in Science: Climate Change and Integrated Pest Management Through the Lens of Communication—2019 Student Debates
Authors: Holt Jocelyn R , Bernaola Lina , Britt Kadie E , McCullough Chirs , Roth Morgan , Wagner Jennie , Ragozzino Max , Aviles Leslie , Li Zhilin , Huval Forest , Pandey Manoj , Lee Benjamin W , Asche Megan , Hayes Abigail , Cohen Abigail , Marshall Adrian , Quellhorst Hannah E , Wilkins Rachel V , Nguyen Valerie , Maille Jacqueline , Skinner Rachel K , Ternest John J , Anderson Sarah , Gula Scott W , Hauri Kayleigh , Eason Julius , Mulcahy Megan , Lee Scott , Villegas James Michael , Shorter Patricia 
Published: July 2020

AbstractEvery year, the Student Debates Subcommittee (SDS) of the Student Affairs Committee (SAC) for the annual Entomological Society of America (ESA) meeting organizes the Student Debates. This year, the SAC selected topics based on their synergistic effect or ability to ignite exponential positive change when addressed as a whole. For the 2019 Student Debates, the SAC SDS identified these topic areas for teams to debate and unbiased introduction speakers to address: 1) how to better communicate science to engage the public, particularly in the area of integrated pest management (IPM), 2) the influential impacts of climate change on agriculturally and medically relevant insect pests, and 3) sustainable agriculture techniques that promote the use of IPM to promote food security. Three unbiased introduction speakers gave a foundation for our audience to understand each debate topic, while each of six debate teams provided a strong case to support their stance or perspective on a topic. Debate teams submitted for a competitive spot for the annual ESA Student Debates and trained for the better part of a year to showcase their talents in presenting logical arguments for a particular topic. Both the debate teams and unbiased introduction speakers provided their insight toward a better understanding of the complexities of each topic and established a foundation to delve further into the topics of science advocacy and communication, climate change, and the many facets of integrated pest management.
Mental Health Symptoms Are Associated With Mild Traumatic Brain Injury History in Active Special Operations Forces (SOF) Combat and Combat Support Soldiers
Authors: Barczak-Scarboro Nikki E , Cole Wesley R , DeLellis Stephen M , Means Gary E , Kane Shawn F , Lynch James H , Mihalik Jason P 
Published: July 2020

Abstract

Introduction
Special Operations Forces (SOF) combat arms and combat support Soldiers are at risk for impaired mental health, such as mood- and stress-related disorders, due to operational and training demands. Additionally, these individuals experience high risk for sustaining mild traumatic brain injury (mTBI). These mTBIs have also been linked to negative psychological outcomes, such as anxiety and depressive symptoms. Studying mental illnesses and their related symptoms alone does not fully address mental health, which may be better understood by 2 separate but overlapping continua measuring both mental illness and subjective well-being (ie, emotional, psychological, and social well-being). Due to the lack of research in this area, current mental health symptoms in active SOF combat Soldiers in relation to mTBI warrants investigation.

Materials and Methods
In this study, 113 SOF combat and combat support Soldiers completed self-report psychological and mTBI history measures during an in-person laboratory setting. These psychometric measures included (1) psychological distress (Brief Symptom Inventory 18), (2) anxiety (Generalized Anxiety Disorder 7-item), (3) posttraumatic stress (PTSD Checklist for DSM-5), (4) somatization (Patient Health Questionnaire-15), and (5) subjective well-being (Mental Health Continuum Short Form).

Results
On average, SOF combat Soldiers endorsed moderate well-being and low psychological distress, somatization, posttraumatic stress, and anxiety. Most SOF combat Soldiers had sustained 1 or more mTBI. We observed mTBI history had significant effects on each dependent variable in the expected directions. History of more mTBIs, controlling for age, was associated with lower subjective well-being as well as higher psychological distress, somatization, posttraumatic stress, and anxiety symptoms.

Conclusion
Although SOF combat Soldiers reported relatively adaptive mental health symptoms across participants, there was considerable variance in the measures reported. Some of the variance in mental health symptoms was accounted for by mTBI history while controlling for age, with reporting higher numbers of lifetime mTBIs and older age being associated with worse mental health symptoms. Longitudinal investigations into these associations and their impact on Soldier performance is warranted.
UniProt-Related Documents (UniReD): assisting wet lab biologists in their quest on finding novel counterparts in a protein network
Authors: Theodosiou Theodosios , Papanikolaou Nikolaos , Savvaki Maria , Bonetto Giulia , Maxouri Stella , Fakoureli Eirini , Eliopoulos Aristides G , Tavernarakis Nektarios , Amoutzias Grigoris D , Pavlopoulos Georgios A , Aivaliotis Michalis , Nikoletopoulou Vasiliki , Tzamarias Dimitris , Karagogeos Domna , Iliopoulos Ioannis 
Published: July 2020

Abstract
The in-depth study of protein–protein interactions (PPIs) is of key importance for understanding how cells operate. Therefore, in the past few years, many experimental as well as computational approaches have been developed for the identification and discovery of such interactions. Here, we present UniReD, a user-friendly, computational prediction tool which analyses biomedical literature in order to extract known protein associations and suggest undocumented ones. As a proof of concept, we demonstrate its usefulness by experimentally validating six predicted interactions and by benchmarking it against public databases of experimentally validated PPIs succeeding a high coverage. We believe that UniReD can become an important and intuitive resource for experimental biologists in their quest for finding novel associations within a protein network and a useful tool to complement experimental approaches (e.g. mass spectrometry) by producing sorted lists of candidate proteins for further experimental validation. UniReD is available at http://bioinformatics.med.uoc.gr/unired/
THER-16. INTERACTION OF IMMUNE SYSTEM WITH ONCOLYTIC MEASLES VIRUS THERAPY IN AN MV-SENSITIVE IMMUNOCOMPETENT MURINE MODEL OF MEDULLOBLASTOMA
Authors: Lal Sangeet , Mueller Sabine , Gupta Nalin , Raffel Corey 
Published: July 2020

Abstract
INTRODUCTION: Oncolytic viruses selectively replicate in tumor cells, and may attract immune cells into the microenvironment to stimulate a systemic antitumor response. We have shown efficacy of oncolytic measles virus (MV) against medulloblastoma (MB) in preclinical models. To study the effect of immune system on MV therapy, we have developed the first immunocompetent MV-sensitive murine model of Group 3 MB (CSCG model) and showed that intratumoral MV treatment of tumor-bearing mice significantly prolonged survival. Herein, we study the interaction of MV therapy and tumor immune microenvironment in this model. METHODS: Naive and MV-preimmunized mice were injected with 200,000 CSCG tumor cells in caudate putamen and tumor-bearing mice were treated identically with intratumoral MV injections (n=5 per group). Tumor growth was monitored by bioluminescence imaging and RT-PCR was performed to assess infiltrating CD4+ and CD8+ T cells in MV-treated and untreated control tumors. RESULTS: RT-PCR of untreated tumors shows an average of 43.4 ±1.45-fold and 13.24 ±1.34-fold increase in infiltrating CD8+T cells and CD4+T cells, respectively, compared to normal brain (n=3). Tumors that responded to MV therapy, but recurred had a dramatic decrease in infiltrating CD8+T cells (2.66 ±0.8-fold higher than normal brain). No significant difference in survival was observed between MV-naive and MV-immunized mice (p= 0.773), indicating that anti-measles immunity does not affect MV efficacy, an important point given that almost all patients have been vaccinated with MV. Long-term survivors, both naïve and MV-immune, remained tumor-free for at least 150 days post treatment. These mice (n=3) were re-challenged with a 3-fold higher number of tumor cells than the original injection, but tumor failed to grow for at least 50 days post-injection. CONCLUSION: This finding strongly suggests MV treatment induces anti-tumor immunity. Ongoing studies are being performed to dissect this immune response and to explore the possibility of enhancing it.
Risks Associated with Growing Non-native Larches in Eastern North America
Authors: Robbins Kathryn 
Published: July 2020

Abstract
Risks associated with growing non-native larches include growth loss and mortality related to their frost susceptibility, shade intolerance, stress on poor sites, diseases, insects, and animal damage. Proper selection of planting sites and seed sources, using disease-free dormant planting stock, and monitoring plantations for injury help reduce these risks.
North. J. Appl. For. 2:101-104, Dec. 1985.
Serology and Behavioral Perspectives on Ebola Virus Disease Among Bushmeat Vendors in Equateur, Democratic Republic of the Congo, After the 2018 Outbreak
Authors: Lucas Ashley , Kumakamba Charles , Lange Christian E , Obel Erby , Miningue Guy , Likofata Jacques , Gillis Amethyst , LeBreton Matthew , McIver David J , Euren Jason , Kreuder Johnson Christine , Goldstein Tracey , Muyembe-Tamfum Jean J , Saylors Karen 
Published: July 2020

Abstract
After the 2018 Ebola outbreak in Equateur Province, Democratic Republic of the Congo, we conducted behavioral interviews and collected samples from bushmeat vendors and primates in Mbandaka to test for evidence of Ebola virus exposure. Although participants indicated being aware of Ebola, they did not consider themselves at occupational risk for infection. We found antibodies against Zaire ebolavirus in one participant despite no reported history of disease or contact with infected individuals. Our data underline concerns of possible subclinical or undiagnosed Ebola virus infections and the importance and challenges of risk communication to populations who are occupationally exposed to bushmeat.
Following the 2018 Ebola outbreak in Equateur Province, Democratic Republic of the Congo, bushmeat vendors interviewed in Mbandaka indicated being aware of Ebola, but did not consider themselves at occupational risk. Antibodies against Zaire ebolavirus were detected in one participant.
Barriers to Adherence to Antimicrobial Stewardship Postprescription Review and Feedback For Broad-Spectrum Antimicrobial Agents: A Nested Case-Control Study
Authors: Takamatsu Akane , Yao Kenta , Murakami Shutaro , Tagashira Yasuaki , Hasegawa Shinya , Honda Hitoshi 
Published: July 2020

AbstractBackgroundPostprescription review and feedback (PPRF) is one of the most common strategies in antimicrobial stewardship program (ASP) intervention. However, disagreements between the prescribers and ASP personnel can occur. The aim of the present study was to identify the factors associated with nonadherence to PPRF intervention.MethodsThe present retrospective nested case-control study was performed at a tertiary care center, which has been conducting a once-weekly PPRF for carbapenems and piperacillin/tazobactam since 2014. Nonadherence to ASP recommendations was defined as the failure of the primary care team to modify or stop antimicrobial therapy 72 hours after the issuance of PPRF recommendations. Factors associated with nonadherence to PPRF intervention were identified using multivariate logistic regression analysis.ResultsIn total, 2466 instances of PPRF in 1714 cases between April 2014 and September 2019 were found. The nonadherence rate was 5.9%, and 44 cases were found in which carbapenems or piperacillin/tazobactam continued to be used against PPRF recommendations. Factors associated with nonadherence to PPRF recommendations were a previous history of hospitalization within 90 days (adjusted odds ratio [aOR], 2.62; 95% confidence interval [CI], 1.18–5.81) and a rapidly fatal McCabe score at the time of PPRF intervention (aOR, 2.87; 95% CI, 1.18–6.98). A review of the narrative comments in the electronic medical records indicated that common reasons for nonadherence were “the patient was sick” (n = 12; 27.3%) and “the antimicrobial seemed to be clinically effective” (n = 9; 20.5%).ConclusionsNonadherence to PPRF recommendations was relatively uncommon at the study institution. However, patients with a severe disease condition frequently continued to receive broad-spectrum antimicrobials against PPRF recommendations. Understanding physicians’ cognitive process in nonadherence to ASP recommendations and ASP interventions targeting medical subspecialties caring for severely ill patients is needed to improve ASP.
Outcomes of Coronavirus Disease 2019 Drive-Through Screening at an Academic Military Medical Center
Authors: Lindholm David A , Kiley John L , Jansen Nathan K , Hoard Robert T , Bondaryk Matthew R , Stanley Elizabeth M , Alvarado Gadiel R , Markelz Ana E , Cybulski Robert J , Okulicz Jason F 
Published: July 2020

AbstractDrive-through coronavirus disease 2019 screening can evaluate large numbers of patients while reducing healthcare exposures and personal protective equipment use. We describe the characteristics of screened individuals as well as drive-through process and outcome measures. Optimal drive-through screening involves rapid turnaround of test results and linkage to follow-up care.
Transmission Dynamics of HIV Subtype A in Tel Aviv, Israel: Implications for HIV Spread and Eradication
Authors: Grossman Zehava , Avidor Boaz , Girshengoren Shirley , Katchman Eugene , Maldarelli Frank , Turner Dan 
Published: July 2020

AbstractObjectiveSubtype-A HIV was introduced into Israel in the mid-1990s, predominantly by immigrants from the former Soviet Union (FSU) infected via intravenous drug use (IVDU). HIV subsequently spread beyond the FSU-IVDU community. In 2012, a mini-HIV outbreak, associated with injection of amphetamine cathinone derivatives, started in Tel Aviv, prompting public health response. To assess current trends and the impact of the outbreak and control measures, we conducted a phyloepidemiologic analysis.MethodDemographic and clinical records and HIV sequences were compiled from 312 subtype-A HIV-infected individuals attending the Tel-Aviv Sourasky Medical Center between 2005–2016, where &gt;40% of all subtype-A HIV-infected individuals in Israel are undergoing care. Molecular evolutionary genetics analysis (MEGA) and ayesian evolutionary analysis sampling trees (BEAST) programs were implemented in a phylogenetic analysis of pol sequences. Reconstructed phylogenies were assessed in the context of demographic information and drug-resistance profiles. Clusters were identified as sequence populations with posterior probability ≥0.95 of having a recent common ancestor.ResultsAfter 2010, the subtype-A epidemic acquired substantial phylogenetic structure, having been unrecognized in studies covering the earlier period. Nearly 50% of all sequences were present in 11 distinct clusters consisting of 4–43 individuals. Cluster composition reflected transmission across ethnic groups, with men who have sex with men (MSM) playing an increasing role. The cathinone-associated cluster was larger than previously documented, containing variants that continued to spread within and beyond the IVDU community.ConclusionsPhyloepidemiologic analysis revealed diverse clusters of HIV infection with MSM having a central role in transmission across ethic groups. A mini outbreak was reduced by public health measures, but molecular evidence of ongoing transmission suggests additional measures are necessary.
774. A New Outpatient Parenteral Antimicrobial Therapy (OPAT) Management Program Reduces Excess Antimicrobial Days of Therapy and Expedites Timely Central Line Removal
Authors: Kidd Catherine , Eby Joshua C , Thomas Tania , Shah Megan , Elliott Zachary , Cox Heather L 
Published: July 2020

Abstract

Background
Patients discharged on parenteral antimicrobials often require in-person follow-up to determine antimicrobial discontinuation and coordination of central line (CL) removal at the end of therapy. Without close attention to timing of follow-up, antimicrobial courses may be extended beyond a planned end date until scheduled follow-up, leading to excess antimicrobial days of therapy (DOT) and CL retention. Excess DOT can result in increased cost of medication and CL supplies, antimicrobial exposure, and risk of CL-associated bloodstream infections or thrombosis. We sought to assess the impact of the University of Virginia (UVA) OPAT program on excess antimicrobial DOT and excess CL days.

Methods
This was a retrospective chart review of patients enrolled in the OPAT program at UVA between August 2018 and April 2019. The UVA OPAT program was started in August 2018. Quality improvement (QI) practice changes were implemented in February 2019 for improving follow-up and stopping antimicrobials at the projected end date. Patients were therefore divided into 2 cohorts – August through January 2018 and February through April 2019. Data collected included projected end date of therapy (EOT), actual EOT, actual removal date of CL, and follow-up date. Excess antimicrobial DOT and excess CL days were calculated by the difference in projected vs. actual dates. For continuous data, Student t-test was used.

Results
248 patients enrolled in OPAT from August 2018 through April 2019. After implementation of QI efforts, mean time from projected EOT to follow-up appointment decreased from 10.0 days to 4.3 days for those with appointments after projected EOT. Mean excess antimicrobial DOT decreased from 2.8 ± 4.53 SD days to 1.6 ± 2.75 SD days (P = 0.026), and mean excess CL days decreased from 3.2 ± 4.63 SD days to 2.0 ± 2.89 SD days (P = 0.035).

Conclusion
The involvement of an OPAT program with close attention to outpatient follow-up and cessation of antimicrobials decreased the excess antimicrobial DOT and CL days and reduced variability in care. Reduction in antimicrobial overuse and CL overuse is expected to reduce cost and decrease the risk of medication- and CL-related collateral damage.

Disclosures
All authors: No reported disclosures.