bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between facet tropism and lumbar disc herniation
Authors: Ye Han , Xiaodong Wang , Zepei Zhang , Shrestha Deepak , Kepeng Li , Yang Song , Jun Miao 
Published: June 2020

Abstract
Purpose The relationship between facet tropism (FT) and lumbar disc herniation (LDH) is not clear. In the present study, MRI was used to assess the relationship between lumbar facet joint tropism and disc herniation. This paper is the first to assess the relationship between facet joint tropism and LDH from the sagittal view. Methods 122 patients (154 segments) with lumbar disc herniation and 102 normal subjects (306 segments) who visited our hospital from 01-Jan-2020 to 01-Apr-2020 were included in this study. The axial and sagittal angles of facet joints were measured using an MRI scan. The difference of 10° in facet angles between left and right was defined as lumbar facet tropism. The relationship between the two was analyzed. Results In the axial, 95/154 segments with lumbar disc herniation had FT whereas, 48/258 segments had FT in the normal segments(p < 0.01). In the sagittal, 61/154 segments with lumbar disc herniation had FT and 48/306 had FT in the control(p < 0.01). Conclusion The proportion of FT is better in patients with lumbar disc herniation, and there is a significant correlation between FT and lumbar disc herniation.
Adsorptive removal of malachite green dye from aqueous solution onto activated carbon of Catha edulis stem as a low cost bio-adsorbent
Authors: Abate Gietu yirga , Alene Adugna Nigatu , Habte Adere Tarekegne , Getahun Desiew Mekuanint 
Published: June 2020

Abstract
Background: The release of hazardous synthetic dyes into industrial effluents has emerged as an environmental problem requiring remediation. The present study focused on the preparation of a new and environmentally-friendly material (adsorbent) for the remediation of aqueous media containing dye. The low cost adsorbent was prepared from locally available khat (Catha edulis) stem which considered as waste and accumulated on waste disposal areas of woldia town, Ethiopia. Comprehensive characterization studies were carried out on the bio-adsorbent such as proximate analyses, specific surface area, and Fourier-Transform Infrared (FTIR) spectroscopy (which shows functional groups on adsorbents surface). Results: The proximate analysis shows the prepared adsorbent has very high fixed carbon content (83.65%), which refers to high quality of the adsorbent. The adsorption performance of the prepared activated carbon was optimize by varying operating parameters such as initial dye concentration (10 mg/L), pH (10), dosage (0.5 g), and contact time (60 min). The maximum removal efficiency of the prepared adsorbent at those optimum conditions was 98.8%. The experimental data was tested by most common kinetics and isotherm models. It was observed that the pseudo-second-order kinetic model fits better with good correlation coefficient and the equilibrium data fitted well with the Freundlich isotherm model. Conclusion: In summery this study demonstrated that the waste bio sorbent could be employed as an effective and eco-friendly alternative for the cleanup of dye-polluted aqueous system.
MtNIP5;1, A Novel Medicago Truncatula Boron Diffusion Facilitator Induced Under Deficiency
Authors: Granado-Rodríguez Sara , Bolaños Luis , Reguera Maria 
Published: June 2020

Abstract
Background: Boron (B) uptake in plants implies a passive diffusion through membranes under optimal conditions. Under deficiency or toxicity, the participation of two distinct protein families (the aquaporin family Major intrinsic proteins (MIPs) and the Boron transporter family BOR) is required to minimize detrimental effects caused by B stress that ends up inhibiting growth and altering development. Legumes comprise important crops that offer major agronomic benefits including the capacity of establishing symbiosis with rhizobia fixing atmospheric N2 and for being important food protein sources. It is well proven their susceptibility to B stress leading to important yield penalties. However, little is known about the transport mechanisms responsible for B uptake and distribution in legumes, especially under deficiency. Results: A novel legume B transporter involved in B uptake under deficiency, the Medicago truncatula homologous protein MtNIP5;1 (Medtr1g097840) to the Arabidopsis thaliana AtNIP5;1 (sharing 73,7% amino acid identity) was identified. Further analyses revealed that this M. truncatula aquaporin expression was boron-regulated in roots, being induced under deficiency and repressed under toxicity. It localizes at the plasma membrane of root epidermal cells and in nodules, where B plays pivotal roles in symbiosis. Furthermore, a partial complementation of the nip5;1 Arabidopsis mutant phenotype under B deficiency supports a functional role of MtNIP5;1 as a B transporter of in this legume model plant. Conclusions: The results here presented support a functional role of MtNIP5;1 uptaking B under deficiency providing new insights into this micronutrient transport mechanisms in legume species.
Water hardness influenced reproductive dynamics in two freshwater fish species; Poecilia reticulata and Betta splendens
Authors: Krishnakumar Abarna , Patrick Anton , Jayawardena Uthpala 
Published: June 2020

Abstract
Objective:
Hardness of water in the form of CaCO3 affect reproductive potential in various fish species, differently. The study evaluates the effect of water hardness on growth and reproduction of two aquarium fishes, Poecilia reticulata (Ovo-viviparous sp.) and Betta splendens (Oviparous sp.) by growing them under 150 (control), 320, 540 and 900 ppm CaCO3 levels in semi natural aquaria.
Results:
Growth increased with increasing water hardness, reporting a significant growth of P. reticulata (p = 0.005) at 900 ppm. Similarly, the reproductive potential of P. reticulata was improved significantly, recording the highest fecundity (16.22 ± 3.90) and Gonadosomatic Index (GSI-2.48 ± 0.597) at 900 ppm. However, in B. splendens water hardness adversely affected the reproduction by reporting a significantly low hatchability and disturbed bubble nests at 900 ppm, compared to the largest bubble nest formed at the control (108.58 ± 16.19 cm2). Thus, study revealed differential effects of water hardness on reproductive potential of the test species, by increasing the potential of P. reticulata while decreasing that of B. splendens. Though larval survival was affected in both species, larval growth was improvement significantly in P. reticulata at 900 ppm level. Understanding reproductive dynamics in natural waters are crucial for propagation and conservation perspectives of freshwater fishes.
Comparation of Laparoscopic Intersphincteric Resection and Abdominoperineal Resection for Ultra-Low Rectal Cancer Patients - a Retrospective Analysis, and a Meta-analysis of Oncology Outcome
Authors: Mo Xianwei , Wang Wentao , Qin Haiquan , Lai Hao , Huang Zigao , Liu Jungang , Zuo Hongqun , Lin Yuan , Tang Weizhong 
Published: June 2020

Abstract
Purpose

The aim of the study is to evaluate the surgical and oncology outcomes between laparoscopic Intersphincteric Resection (LISR) and laparoscopic-assisted Abdominoperineal Resection (LARC) for ultra-low rectal cancer patients by using a retrospective analysis, and a meta-analysis of the literature was carried out to further validate the oncology outcome.
Patients and methods:

Between April 2014 and December 2015, a total of 38 rectal cancer patients who underwent LISR and 41 LARC patients were enrolled in this study. The comparison between the groups was based on clinicopathological characteristics and surgical outcomes. Meta-analysis of published studies, exploring oncology outcome of between LISR and LARC, was carried out using STATA 12.0 software.
Results

Operating time, blood loss, length of hospital stay, and postoperative complication rates was similar between LISR group and LARC group; Patients undergoing LISR also had a similarly 5-year local recurrence and overall survival rate with LAPR. Meta-analysis showed that five studies, which included a total of 791 patients were final involved for this analysis. Comparing APR, ISR patients obtain similarly 5-years recurrence rate and 5-years survival rate.
Conclusion

This study suggests that LISR is as technically feasible, safe, and effective as LARC for treating patients with low rectal cancer. Additional high-powered randomized trials are needed to determine whether LISR truly offers any advantages.
Leadership Perspectives on Learning Health Systems: a qualitative study
Authors: Enticott Joanne , Braaf Sandy , Johnson Alison , Jones Angela , Teede Helena 
Published: June 2020

Abstract
Background: Integrated utilisation of digital health data has the power to transform healthcare to deliver more efficient and effective services, and the learning health system (LHS) is emerging as a model to achieve this. The LHS uses routine data from service delivery and patient care to generate knowledge to continuously improve healthcare. The aim of this project was to explore key features of a successful and sustainable LHS to inform implementation in an Academic Health Science Centre context.Methods: We purposively identified and conducted semi-structured qualitative interviews with leaders, experienced in supporting or developing data driven innovations in healthcare. A thematic analysis using NVivo was undertaken.Results: Analysis of 26 interviews revealed five themes thought to be integral in an effective, sustainable LHS: (1) Systematic approaches and iterative, continuous learning with implementation into healthcare contributing to new best-practice care; (2) Broad stakeholder, clinician and academic engagement, with collective vision, leadership, governance and a culture of trust, transparency and co-design; (3) Skilled workforce, capability and capacity building; (4) Resources with sustained investment over time and; (5) Data access, systems and processes being integral to a sustainable LHS. Conclusions: This qualitative study provides insights into the elements of a sustainable LHS across a range of leaders in data-driven healthcare improvement. Fundamentally, an LHS requires continuous learning with implementation of new evidence back into frontline care to improve outcomes. Structure, governance, trust, culture, vision and leadership were all seen as important along with a skilled workforce and sustained investment. Processes and systems to optimise access to quality data were also seen as vital in an effective, sustainable LHS. These findings will inform a co-designed framework for implementing a sustainable LHS within the Australian healthcare and Academic Health Science Centre context. It is anticipated that application of these findings will assist to embed and accelerate the use of routine health data to continuously generate new knowledge and ongoing improvement in healthcare delivery and health outcomes.
Evaluation of The Standard Procedure for the Treatment of Periprosthetic Joint Infections (PJI) in Germany - Results of a Survey within the EndoCert Initiative
Authors: Rimke Christina , Enz Andreas , Bail Hermann Josef , Heppt Peter , Kladny Bernd , von Lewinski Gabriela , Lohmann Christoph H. , Osmanski-Zenk Katrin , Haas Holger , Mittelmeier Wolfram 
Published: June 2020

Abstract
Background: The PJI is a severe complication in the field of arthroplasty.Despite the rising number of primary joint replacements, no therapeutic standard has been established for the treatment of PJI yet.Methods: A survey on the principles of treatment of PJI in Germany wasconducted. A total of 515 EndoProthetikZentren were included, resulting in a response rate of 100%.Results: For early infections 97.6% of the centers use DAIR. A one-stage exchange was implemented by less than 50% of the centers. If implemented, this treatment entails a prior selection of patients for a successful treatment. The two-stage exchange is performed in all centers, and most centers proceed with the implantation of a cemented spacer between stages. 75% of the centers proceed with a center-based concept for the treatment of PJI.Conclusion: The rising number of primary joint replacements underlines the importance of developing standards and harmonized definitions for the treatment of PJI. These standards have not yet been fully achieved. The most relevant treatment options in Germany are displayed. The two-stage revision with a cemented spacer is the most widely implemented treatment option in Germany. This summary of principles could serve as a basis for the development of standardized treatment guidelines and definitions.
Short- and Long-Term Outcomes of Laparoscopic Surgery for Colorectal Cancer in the Elderly Aged Over 80 Years Old Versus Non-Elderly: A Retrospective Cohort Study
Authors: Ueda Yoshitake , Shiraishi Norio , Kawasaki Takahide , Akagi Tomonori , Ninomiya Shigeo , Shiroshita Hidefumi , Etoh Tsuyoshi , Inomata Masafumi 
Published: June 2020

Abstract
Background Recently, colorectal cancer has increased in elderly patients worldwide, with laparoscopic colorectal surgery increasing in elderly patients with colorectal cancer. However, whether laparoscopic colorectal surgery is an optimal procedure for colorectal cancer in the elderly remains unclear.Objective This study aimed to verify safety and curability of laparoscopic colorectal surgery in elderly patients ≥80 years old.Methods Patients undergoing curative colorectal surgery from 2006 to 2014 were enrolled and classified into the laparoscopic surgery in elderly patients aged ≥80 years (LAC-E) group, open surgery in elderly patients (OC-E) group, and laparoscopic surgery in non-elderly patients (LAC-NE) group. Short- and long-term outcomes were compared between these groups.Results The LAC-E, OC-E, and LAC-NE groups comprised 85, 25, and 358 patients, respectively. Intraoperative blood loss and incidence of postoperative complications were significantly lower in the LAC-E versus OC-E group (97 vs. 440 mL, p<.01 and 14% vs. 32%, p<.05, respectively). Long-term outcomes were not different between these two groups. Operation time was significantly shorter in the LAC-E versus LAC-NE group (249 vs. 288 min, p<.01). Intraoperative blood loss and postoperative complications were similar between the groups. Although the 5-year overall survival rate in the LAC-E group was lower than that in the LAC-NE group (64% vs. 80%, p<.01), there was no difference in 5-year disease-specific survival between the groups.Conclusions Laparoscopic colorectal surgery is technically and oncologically safe for colorectal cancer in the elderly as well as the non-elderly and can be an optimal procedure for colorectal cancer in the elderly.
Mid-late pregnancy maternal glycolipids in gestational diabetes mellitus (GDM) fluctuated in glycosylated hemoglobin levels of 5.5%-6.4% associated with umbilical cord blood of amino acid and carnitine profiles: a nested case-cohort observational study
Authors: yuhang long , Chen Le , Yang Yaochao , Liu Wei , Zhang Hanxi , Chen WuJuan , Jiang Fangfang , Hong Ting , Wang Jianying , Chen Yao , Cao Jianyong , Xie Dan , Su Zhaojuan 
Published: June 2020

Abstract
Background

To explore the relationship between maternal-neonatal clinical data and the changes of cord blood amino acid and carnitine levels between pregnant women with gestational diabetes mellitus (GDM) when glycosylated hemoglobin levels of 5.5%-6.4% excluded diabetic medicine as GDMa group and the control group.
Methods

In all, 312 qualified participants were recruited with permission from the ethical department of the Fifth Affiliated Hospital of Sun Yat-Sen University and divided into two groups (GDMa and non-GDM) after adjusting for maternal age and body mass index (BMI) between the 1 June 2017 and 30 April 2020. All maternal-neonatal data were collected and analysed at the centre.
Results

Interestingly, glycine in cord blood was not only significantly different between groups(594.19 vs 407.45, P < 0.001), but also associated among those pregnant women in GDM when glycosylated hemoglobin levels of 5.5%-6.4% through the standard of diet control and exercise (b = 0.449, P = 0.010). Meanwhile, neonatal hypoglycemia had the positive association with GDM monitoring glycosylated hemoglobin levels of 5.5%-6.4% (P = 0.031, OR 5.77 95%CI[1.18, 28.36]), but none of correlations with umbilical cord blood of amino acids and carnitines.
Conclusions

The study identifies some differences and relationships in maternal-neonatal data only when GDMa group, glycosylated hemoglobin levels of 5.5%-6.4% without diabetic medicine, compared with the control group which adjusted by age and BMI. Particularly, umbilical cord blood of glycine levels is related to the diabetic status of glycosylated hemoglobin 5.5%-6.4% in GDM during pregnancy and could be potential diabetic mechanism by maternal-fetal interface.
Time Trends in Comorbidity and Management of Hypertension and Diabetes: A 15-year Nationwide Longitudinal Study of 18,380 Adults in China
Authors: Li Yixuan , Sun Xiaomin , Wei Junxiang , Wu Jing , Wang Youfa 
Published: June 2020

Abstract
Background: To examine time trends in comorbidity of hypertension and type 2 diabetes (T2DM) and their diagnosis, treatment, and management in China during 2000-2015 and study factors associated with these outcomes. Methods: Longitudinal data collected from the China Health and Nutrition Survey (CHNS) during 2000-2015 were analyzed. Of the 28,204 adults, 832 had both hypertension and T2DM were selected. Average systolic blood pressure (SBP) and diastolic blood pressure (DBP) and hypertension prevalence among T2DM patients, and treatment and control of hypertension and T2DM among patients with both conditions were examined for all and by sex and weight status. Mixed effects models assessed the associations. Results: From 2000 to 2015, among patients with T2DM, hypertension prevalence dropped from 88.4% to 83.0% and BPs decreased (P < 0.05). Men and overweight/obese patients had greater decreases in hypertension prevalence and DBP, while women had a larger decrease in SBP than men. Over time, among patients with both hypertension and T2DM, rates of hypertension treatment (45.3% to 57.7%), hypertension control (3.0% to 10.9%) and T2DM treatment (90.0% to 95.6%) increased, but were still very low except for T2DM treatment (all P < 0.001). Age, gender, smoking, drinking, household income, education, residence, and weight status were significantly associated with prevalence, treatment, and control of hypertension, and T2DM treatment among patients with both hypertension and T2DM. Conclusion: Rates of hypertension treatment and control among patients with both hypertension and T2DM have improved in recent years, but were still low.
Nomogram for Predicting Survival in Mucinous Adenocarcinoma of Prostate
Authors: Li Jiakun , Qiu Shi , Cui Xi-nan , Jin Kun , Zheng Xiaonan , Tu Xiang , Ge Liming , Yang Lu , wei qiang 
Published: June 2020

Abstract
Background: Few studies on predicting survival in patients with histology of mucinous adenocarcinoma of the prostate have been done.Objective: Nomogram is a mathematical model in which various important factors are combined to predict a specific end point. The purpose of this study was to evaluate the prognostic value of clinical factors in patients with mucinous adenocarcinoma and to construct nomogram to predict the survival rate. Design,Setting,and Participants: A nomogram was designed to predict the survival rate of 356 patients with invasive ductal carcinoma selected from the surveillance, epidemiology and final results (SEER) database. Univariate and multivariate models of the cohort were done firstly.And then a model of nomogram that included age, race, grade, stage M and chemotherapy were constructed to predict the 3-year and 5-year survival of prostate cancer patients with histology of mucinous adenocarcinoma. Based on different time, we designed two nomograms.Results and limitations: After the discrimination and calibration, C-index was 0.8138. The specificity was 86.12%, sensitivity was 55.89% for 3-year nomogram . Its survival was 91.49% and AUC was 0.7467. The specificity was 82.42%, sensitivity was 54.83% for 5-year nomogram. Its Survival was 86.73% and AUC was 0.7555. Respectively, which indicated relative good discrimination of the nomogram. Conclusions: This clinical model shows a high ability to predict the survival rate of mucinous adenocarcinoma patients with histologically prostate cancer, making this model a novel and attractive model for predicting the survival rate of patients.
Genetic Analysis Reveals Unique Characteristics of Plasmodium Falciparum Parasite Populations in Haiti
Authors: Daniels Rachel , Chenet Stella , Rogier Eric , Lucchi Naomi , Herman Camelia , Pierre Baby , Lemoine Jean Frantz , Boncy Jacques , Wirth Dyann , Chang Michelle , Udhayakumar Venkatachalam , Volkman Sarah 
Published: June 2020

Abstract
Background: With increasing interest in eliminating malaria from the Caribbean region, Haiti is one of the two countries on the island of Hispaniola with continued malaria transmission. While the Haitian populace remains at risk for malaria, there are a limited number of cases annually, making conventional epidemiological measures such as case incidence and prevalence of potentially limited value for fine-scale resolution of transmission patterns and trends. In this context, genetic signatures may be useful for the identification and characterization of the Plasmodium falciparum parasite population in order to identify foci of transmission, detect outbreaks, and track parasite movement to potentially inform malaria control and elimination strategies. Methods: This study evaluated the genetic signals based on analysis of 21 single-nucleotide polymorphisms (SNPs) from 462 monogenomic (single-genome) P. falciparum DNA samples extracted from dried blood spots collected from malaria-positive patients reporting to health facilities in three southwestern Haitian departments (Nippes, Grand’Anse, and Sud) in 2016. Results: Assessment of the parasite genetic relatedness revealed evidence of clonal expansion within Nippes and the exchange of parasite lineages between Nippes, Sud, and Grand'Anse. Furthermore, 437 of the 462 samples shared high levels of genetic similarity­­—at least 20 of 21 SNPS—with at least one other sample in the dataset. Conclusions: These results revealed patterns of relatedness suggestive of the repeated recombination of a limited number of founding parasite types without significant outcrossing. These genetic signals offer clues to the underlying relatedness of parasite populations and may be useful for the identification of the foci of transmission and tracking of parasite movement in Haiti for malaria elimination.