bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of COVID-19 Possibilities using KNN Classification Algorithm
Authors: Theerthagiri Prasannavenkatesan , Jacob I.Jeena , Ruby A.Usha , Y.Vamsidhar  
Published: November 2020

Abstract
This paper studies the different machine learning classification algorithms to predict the COVID-19 recovered and deceased cases. The k-fold cross-validation resampling technique is used to validate the prediction model. The prediction scores of each algorithm are evaluated with performance metrics such as prediction accuracy, precision, recall, mean square error, confusion matrix, and kappa score. For the given dataset, the k-nearest neighbour (KNN) classification algorithm produces 80.4 % of predication accuracy and 1.5 to 3.3 % of improved accuracy over other algorithms. The KNN algorithm predicts 92 % (true positive rate) of the deceased cases correctly with 0.077 % of misclassification. Further, the KNN algorithm produces the lowest error rate as 0.19 on the prediction of accurate COVID-19 cases than the other algorithm. Also, it produces the receiver operator characteristic curve with the output value of 82 %.
Fully printed, all-carbon, recyclable electronics
Authors: Williams Nicholas , Bullard George , Brooke Nathaniel , Therien Michael , Franklin Aaron 
Published: November 2020

Abstract
The rapid growth of electronic waste must be curtailed to prevent accumulation of environmentally and biologically toxic materials, which are essential to traditional electronics1. The recent proliferation of transient electronics has focused predominantly on biocompatibility(2,3), and studies reporting material recapture have only demonstrated reuse of conducting materials(4–6). Meanwhile, the ideal solution to the electronic waste epidemic — recapture and reuse of all materials — has been largely neglected. Here we show complete recyclability of all materials in printed, all-carbon electronics using paper substrates, semiconducting carbon nanotubes, conducting graphene, and insulating crystalline nanocellulose. The addition of mobile ions to the dielectric produced significant improvements in switching speed, subthreshold swing, and among the highest on-current for printed transistors. These devices evinced superlative stability over 6 months, after which they are shown to be controllably decomposed for complete recycling of materials and re-printing of devices with similar performance to baseline devices. The printing of all-carbon, recyclable electronics presents a new path toward green electronics with potential to mitigate the environmental impact of electronic waste. We anticipate all-carbon, recyclable electronics to be a watershed, facilitating internet-of-everything applications, such as ubiquitous sensors for continuous monitoring of diseases or environmental conditions, while preserving carbon neutrality in the device lifecycle.
The technique for less infectious and earlier healing of stoma closure wound: Negative Pressure Wound Therapy with instillation and dwelling followed by primary closure
Authors: yane Yoshinori , Hida Jin-ichi , Makutani Yusuke , Ushijima Hokuto , Yoshioka Yasumasa , Iwamoto Masayoshi , Wada Toshiaki , Daito Koji , Tokoro Tadao , Ueda Kazuki , Kawamura Junichiro 
Published: November 2020

Abstract
Background:Temporary stomas have been widely used to avoid the risk of complications such as anastomotic leakage after colorectal resection. Stoma closure is relatively easy; however, postoperative surgical site infection (SSI) may be a problem. Various methods have been used to reduce the incidence of SSI. We aimed to evaluate a new technique for stoma wound closure.Methods:We enrolled patients who underwent stoma closure at our hospital between September 2019 and May 2020. We selected patients who lived far from our hospital and had difficulty visiting the hospital regularly and who agreed to undergo this surgical technique. We used negative pressure wound therapy with instillation and dwelling (NPWTi-d) and delayed primary closure for these patients.Results:Four patients underwent NPWTi-d and delayed primary closure without the occurrence of SSI. The median postoperative hospital stay was 9 days (range: 7-14 days), and the median number of days to confirmation of epithelialization was 11.5 days (range: 10-16 days).Conclusion:The combined use of NPWTi-d and delayed primary closure for the stoma wound was very effective. This method may be a valuable new technique for wound management after stoma closure.
Design of Intelligent Diagnosis System for Teaching Quality Based on Wireless Sensor Network and Data Mining
Authors: Zhang Yanping , Huang Wanwei 
Published: November 2020

Abstract
With the popularization of computers and various mobile intelligent terminals, intelligent teaching systems based on learners are becoming more and more popular among learners. The above phenomenon has greatly affected and changed the current teaching quality diagnosis methods and models. However, the author found through investigation that the current intelligent teaching quality diagnosis still has different degrees of deficiencies in the design and implementation. In response to the above problems, this paper proposes a teaching quality intelligent diagnosis model based on the combination of wireless sensor networks and fuzzy comprehensive evaluation algorithms. First of all, this article is based on the wireless sensor network to link various levels of intelligent teaching systems, and constructs the information transmission structure of the teaching intelligent diagnosis system. Secondly, this article uses fuzzy comprehensive evaluation and convolutional neural network algorithms to evaluate and excavate intelligent teaching information. Finally, the model successfully passed the simulation test and simulation application, which can provide intelligent diagnosis of teaching quality for modern intelligent teaching system.
Short report: Nucleotides supplementation to whole milk has beneficial effects on post-weaning Holstein calf performance
Authors: Abbaslou Yousef , Zahmatkesh Davood , Mahjoubi Ehsan , Yazdi Mehdi Hossein , Beiranvand Hamed , Gorjidooz Morteza 
Published: November 2020

Abstract
The positive effects of nucleotides (NU) supplementation in milk replacer has been elucidated in infants and in dairy calves; however, NU addition to whole milk has not been evaluated previously. This study aimed to assess NU supplementation in the whole milk on calf growth and health. Thirty Holstein calves (body weight: 39.1 ± 1.0 kg; 3 d after birth) were randomly assigned to following treatments: whole milk without any supplementation (NU0), whole milk + 0.5 g/d added NU to whole milk (NU0.5), and whole milk + 1 g/d added NU to whole milk (NU1). Calves were weaned at d 55 and stayed on study until d 75. Calves had free access to feed and water throughout the study. Calves fed all treatments were similar (P > 0.05) in dry matter intake (DMI) during the pre-weaning period, however increasing NU supplementation resulted in a linear (P < 0.05) increase in DMI during the post weaning period. Treatments did not affect body weight (BW) at the first and second month of study but final BW linearly increased as NU was added. Neither pre-weaning average daily gain nor post-weaning average daily gain were affected by treatments; accordingly, feed efficiency was similar among treatment groups. Days with loose fecal score were linearly decreased as NU was added to whole milk during the first month of life, while the fecal score did not differ among treatments until the end of the study. No difference was observed in the skeletal growth of calves in the current study. Therefore, it can be concluded that NU supplementation in the whole milk has some beneficial effects on calf performance in terms of final BW, post-weaning DMI, and less days with loose feces.
Overcoming the UCB HSCs –Derived NK Cells Dysfunctionality through Harnessing RAS/MAPK, IGF-1R and TGF-β Signaling Pathways
Authors: Shokouhifar Alireza , Sarab Gholamreza Anani , Yazdanifar Mahboubeh , Fereidouni Mohammad , Nouri Masoumeh , Ebrahimi Marzieh 
Published: November 2020

Abstract
BackgroundNatural killer (NK) cells differentiated from umbilical cord blood (UCB) hematopoietic stem cells (HSCs) may be more suitable for cell-based immunotherapy compared to NK cells from adult donors. This is due to opportunity to choose alloreactive donors and potentially more robust in vivo expansion. However, the cytotoxicity of UCB-HSC derived NK cells against cancer cells might be suboptimal. To overcome this obstacle, we attempted to generate NK cells with potent antitumor activity by targeting RAS/MAPK, IGF-1R and TGF-β signaling pathways.MethodsThe CD34+ cells isolated from human UCB mononuclear cells through MACS with purity of (≥90%) were used to be differentiated into NK cells. After 21 days of induction with SFTG36, IS721 and IL-15/Hsp70 media, NK cells phenotype was studied and their cytotoxicity against K562 human erythroleukemia cell and SKOV3 ovarian carcinoma cells was analyzed.ResultsThe induced NK cells treated with SFTG36/I721 and SFTG36/IS721 growth factor cocktail expressed a phenotype with CD56+16+CD3- and NKG2D+ with mean fluorescence intensity (MFI) of 92.7%±1.45-168.00±19.20 and 93.23%±0.75-168.66±20.00 respectively. These NK cells once activated by IL-15, demonstrated a higher cytotoxicity against K562 (≥90%) (P ≤ 0.001) and SKOV3 tumor cells (≥65%) (P ≤ 0.001) compared to IL-15/Hsp70 activated NK cells.Conclusion The differentiation of ex vivo-expanded CD34+ cells through manipulation of RAS/MAPK, IGF-1R and TGF-β signaling pathways is an efficient approach for generating functional NK cells that can be used for cancer immunotherapy.
Lipid Profile in Opium Users: Results of Fasa PERSIAN&nbsp;Cohort Study, First Phase
Authors: Kazemi Maryam , Bazyar Mina , Naghizadeh Mohammad Mehdi , Dehghan Azizallah , Rahimabadi Massih Sedigh , Chijan Mahsa Rostami , Bijani Mostafa , Zahmatkeshan Maryam , Ghaemi Alireza , Samimi Nastaran , Homayounfar Reza , Farjam Mojtaba 
Published: November 2020

Abstract
Background: One of the main health problems in many societies is the increase of opium abuse which correlated with many problems such as cardiovascular disease. The goal of our study is to evaluate the correlation of opium use with blood lipoproteins as risk factors of CVD.Methods: This is a cross-sectional study on participants of the first phase of the PERSIAN Cohort study who were 35 -70 years old. Demographic characteristics, history of smoking, alcohol, and opium consumption, medical history and medications were asked and checklists were filled out. level of physical activity and fat intake was registered. lipoprotein profiles were investigated by blood sampling. IBM SPSS Statistics v21 was used to analyze the correlation of opium and lipid profile and the significant level was <0.05.Results: From 9300 participants with a mean age of 48.06±9.44 years old, 49.6% were male. About 24.1% of participants used opium. The level of total cholesterol (adjusted p= 0.02) and HDL (adjusted p= 0.04) in people who used opium was significantly lower than others. But, the level of triglyceride (p=0.11) and LDL (adjusted p= 0.06) was not different in users and non-users. LDL (OR=0.8, adjusted p= 0.009) and total cholesterol (OR=0.81, adjusted p= 0.007) had normal level in people who used opium than non-consuming people.Conclusion: This study showed that there is correlation between opium usage and lower level of total cholesterol and LDL, however the lower level of HDL in normal range was seen in opium users.
Using a Behavioral Model to Assess the Barriers and Facilitators to Engaging Local Healthcare Providers in Conducting Interventional Cancer Trials in Nigeria
Authors: Ibraheem Abiola , Oluwasanu Mojisola , Akinbami Akinsegun , Sowunmi Akinyimika , Odedina Stella , Popoola Abiodun , Cipriano Toni , Olopade Olufunmilayo , Oladepo Oladimeji , Polite Blase 
Published: November 2020

Abstract
PURPOSE: Globalization of cancer clinical trials is now involving low middle income countries such as Nigeria as a rationale for global equity. With this ongoing clinical trial globalization, it is important to engage stakeholders such as local providers at the institutions where these trials are conducted by improving knowledge and perception of local providers concerning clinical trials.METHODS: This is a qualitative focused group study consisting of ten groups conducted at Lagos State University Teaching Hospital between November 2019 and January 2020 using locally developed probe questions to engage local providers according to departments. Transcripts of semi-structured interviews was analyzed using direct content analysis and was mapped against the implementation theory of capability, opportunity and motivation for behavior change(COM-B) to access the challenges and barriers reported by local providers. RESULTS: 239 local providers participated in this study, the challenges identified by providers were low knowledge about clinical trials, poor attitudes and systemic barriers. The opportunities suggested by local providers to improve the conduct of clinical trial in that environ included clinical trial workshops to improve baseline knowledge and perception and team collaboration between providers. CONCLUSION: As cancer clinical trials are being globalized, the local healthcare community should be brought to par with this new intervention and not be left behind. Training about clinical trials should not be limited to providers actively involved in the clinical trials but all the providers in that region should be empowered by improving the baseline knowledge and perception of clinical trials.
Chloroquine use in the Treatment of COVID-19: Systems Biology Report of Common Targets of SARS-CoV-2 and Chloroquine.
Authors: Souchelnytskyi Serhiy , Souchelnytskyi Nazariy 
Published: November 2020

Abstract
BACKGROUND: Chloroquine use for treatment of COVID-19 patients has been under discussion and recommendations have been shifting from positive to caution or non-conclusive. Variability of clinical outputs requires understanding of mechanisms of the differences. Implementation of a companion diagnostic would allow selecting patients who may benefit from the drug. The first line would be markers already used in clinics. Systems biology opens for an opportunity to identify targets common for chloroquine and SARS-CoV-2. These common targets would be candidates for the companion diagnostic.METHODS: Systemic analysis of molecular mechanisms and markers engaged by chloroquine and SARS-CoV-2 virus was performed. The networks of regulatory mechanisms were explored for an intersection and relevance to clinical markers.RESULTS: Reported here systemic analysis describes the intersection of molecular mechanisms of chloroquine and processes engaged by COVID-19. 266 nodes provide insight into the mechanisms of chloroquine impact on the infection and represent a pool of companion diagnostic markers. As an example, an intersection with the markers of heart arrhythmia retrieved 19 nodes. Thirteen of them were reported in human plasma: levels of albumin, amyloid precursor protein, and endoglin correlate with adverse cardiac effects. CONCLUSIONS: Reported intersection nodes of SARS-CoV-2 and chloroquine are the candidate markers for companion diagnostic of the chloroquine application. Some of these markers are already used in the clinic and their interpretation may contribute to monitoring for adverse effects of chloroquine.
The Effect of Various Urban Design Parameter in Alleviating Urban Heat Island and Improving Thermal Health- A Case Study in a Built Pedestrianized Block of China
Authors: Ma Xuan , Zhao Jingyuan , Zhang Lei 
Published: November 2020

Abstract
BackgroundIncreasing urban heat island and global warming have aroused serious thermal environmental problems, even do harm to people’s thermal health. Because the importance in people’s daily life, Commercial pedestrianized block represents a symbol of a city or metropolis, therefore, focusing the attention on the thermal environment in such regions is very necessary. Most of the researches on urban thermal environment are calculated by remote sensing data, limited by the low spatial resolution of remote sensing image, it may not obviously reflect the true thermal environment of the research site, especially in some micro-scale regions. MethodsBased on this, the new software ENVI-met is developed to research the thermal environment and forecast people’s thermal sensation in micro-scale region. ResultsTherefore, the objective of this study aims at conducting field measurement and numerical simulation to assess the thermal environment of a typical commercial pedestrianized space in southern China, and assess the different urban design parameter in ameliorating urban heat island effect. Conclusions﻿Our final results demonstrate a quantitative evidence for establishing a comprehensive standard for improving thermal environment in micro-scale region, and this study also can be a supplementary in the research field about improving thermal health.
Preoperative Controlling Nutritional Status (CONUT) Score Predicts Short-term Surgical Outcomes in Patients with Gastric Cancer After Laparoscopy-assisted Radical Gastrectomy
Authors: Qian Yun , Liu Huaying , Pan Junhai , Yu Weihua , Lv Jiemin , Yan Jiafei , Gao Jiaqi , Wang Xianfa , Ge Xiaolong , Zhou Wei 
Published: November 2020

Abstract
Background: The Controlling Nutritional Status (CONUT) score is an emerging nutrition assessment tool that is useful in gastric cancer (GC) patients. The aim of our study was to assess the predictive ability of the preoperative CONUT score for short-term outcomes in GC patients undergoing laparoscopy-assisted gastrectomy.Methods: We retrospectively reviewed the medical records of 309 patients who underwent curative laparoscopy-assisted gastrectomy. The patients were divided into two groups according to the optimal cut-off value of the CONUT score. The clinical characteristics and postoperative complications were evaluated and analysed in the low- and high-score groups. The risk factors for complications were identified by univariate and multivariate analysis.Results: The preoperative CONUT score showed a good predictive ability for postoperative complications (area under the curve (AUC)=0.718, Youden index=0.343) compared with other indexes, with an optimal cut-off value of 2.5. Patients with high CONUT scores had a higher incidence of overall complications (P<0.001) and mild complications (P<0.001). Univariate and multivariate analyses revealed that the CONUT score was independently associated with postoperative complications (P=0.012; odds ratio (OR)=2.433; 95% confidence interval (CI): 1.218-4.862).Conclusions: The preoperative CONUT score is a reliable and useful nutritional assessment tool for predicting short-term outcomes in GC patients after laparoscopy-assisted gastrectomy.
Prognostic Significance of Enlarged Paraaortic Lymph Nodes Detected During Left-sided Colorectal Cancer Surgery: A Single-Center Retrospective Cohort Study
Authors: Lee Jaram , Park Hyeong-min , Lee Soo Young , Kim Chang Hyun , Kim Hyeong Rok 
Published: November 2020

Abstract
Background: Very few studies have been conducted on the treatment strategy for enlarged para-aortic lymph nodes (PALNs) incidentally detected during surgery. The purpose of this study was to investigate the benefit of lymph node dissection in patients with incidentally detected enlarged PALNs.Methods: We retrospectively reviewed left colon and rectal cancer patients who underwent surgical resection with PALN dissection between January 2010 and December 2018. The predictive factors for pathologic PALN metastasis (PALNM) were analyzed, and survival analyses were conducted to identify prognostic factors.Results: Among 263 patients included, 19 (7.2%) patients showed pathologic PALNM, and 5 (26.33%) of them had enlarged PALNs incidentally detected during surgery. These 5 patients accounted for 2.2% of 227 patients who had no evidence of PALNM in preoperative radiologic examination. Radiologic PALNM (odds ratio [OR] 12.737, 95% confidence interval [CI] 3.472–46.723) and radiologic distant metastasis other than PALNM (OR = 4.090, 95% CI 1.011–16.539) were independent predictive factors for pathologic PALNM. Pathologic T4 stage (hazard ratio [HR] 2.196, 95% CI 1.063–4.538) and R2 resection (HR 4.643, 95% CI 2.046–10.534) were independent prognostic factors for overall survival (OS). In patients undergoing R0 resection, pathologic PALNM was not associated with the 5-year OS (90% vs. 82.2%, p = 0.896). Conclusions: Dissection of enlarged PALNs incidentally detected during colorectal surgery may benefit patients, with favorable survival outcomes.
A Randomized, Controlled Clinical Trial of Autologous Adipose-derived Stem Cell Transplantation to Promote Mechanical Stretch-induced Skin Regeneration
Authors: Tan Poh-Ching , Chao Pei-Chuan , Cheng Chen , Chen Chu-Hsin , Huang Ru-Lin , Zhou Shuang-Bai , Xie Yun , Li Qingfeng 
Published: November 2020

Abstract
Background: The regeneration response of skin to mechanical stretching in vivo has been explored in reconstructive surgery for repairing large-scale deformities. The ability of skin to regenerate limits the reconstructive outcome. Here, we propose an approach in which autologous adipose-derived stem cells and mechanical stretching are combined to overcome this limitation and promote skin regeneration.Methods: This randomized, blinded, placebo-controlled clinical trial screened 22 participants undergoing tissue expansion with a presence of exhausted regeneration. Twenty eligible participants received intradermal injections with stromal vascular fraction (SVF) or placebo treatments. Follow-ups were conducted at 4, 8, and 12-weeks to assess efficacy and for 2-years to assess safety. The primary endpoint was the expanded skin thickness at 12 weeks. The secondary endpoints included the skin thickness at 4 and 8 weeks, the expansion index (EI) and the skin texture score at all visits. Results: The skin thickness of the SVF group was significantly higher than that of the control group at both 8 weeks (mean difference 0.78 [95% CI -1.43 to -0.11]; p = 0.018) and 12 weeks(0.65 [95% CI -1.30 to -0.01]; p = 0.046). In the SVF group, the increment of skin thickness was significant at 4 weeks (0.49 [95% CI -0.80 to -0.06]; p = 0.010) to 8 weeks (0.45 [95% CI -0.92 to 0.02]; p = 0.026) and maintained after 12 weeks, whereas that in the control group was reduced after 8 weeks (0.42 [95% CI -0.07 to 0.91]; p = 0.037). The SVF group showed higher EI increments than the control group (0.50 [95% CI -0.00 to 0.99]; p = 0.047). The skin texture scores in the SVF group were higher than those in the control group at 12 weeks. Histologically, the SVF-treated expanded skin showed more proliferating cells and blood vessels, and the volume of extracellular matrix increased. No severe adverse events occurred.Conclusions: Transplantation of autologous adipose-derived stem cells can expedite the potency of mechanical stretch-induced skin regeneration and provide clinical reconstruction with plentiful tissue. Trial registration: This trial was registered with Chinese Clinical Trial, ChiCTR2000039317 (registered 23 Oct 2020 - retrospectively registered, http://www.chictr.org.cn/showproj.aspx?proj=62738).