bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reasons for HR analytics adoption in public sector organisations: evidence from Swedish public administrations
Authors: Espegren Yanina 
Published: December 2024

PurposeThis study explores the rationale behind the utilisation of human resource (HR) analytics in public sector organisations. The existing HR analytics literature exhibits limited empirical evidence and has predominantly focused on the business context of private firms. In addressing this gap, the study seeks to answer the following research question: What reasons for the adoption of HR analytics can be identified in public sector organisations?Design/methodology/approachThe study employs a qualitative approach drawing on the empirical data collected from three public administrations in Sweden – national, regional and local. A total of 51 in-depth interviews are conducted with HR and other organisational practitioners engaged in HR analytics practices.FindingsDrawing on the institutional legitimacy perspective, this paper suggests that public sector organisations adopt HR analytics to secure cognitive, socio-political and technological legitimacy, stemming from explanations rooted in economic rationality. This encompasses organisational and HR-related outcomes achieved through data management and analysis, driven by the personal interests of specific individuals.Research limitations/implicationsThis study contributes to ongoing debates about the adoption of HR analytics in diverse contextual settings. Future research is needed in other organisational contexts, including various national and international settings.Practical implicationsThe results of this study offer practical insights for HR practitioners in public sector organisations seeking to adopt HR analytics to enhance organisational and HR legitimacy.Originality/valueThis study contributes to the HR analytics literature by providing empirical evidence from the public sector. Furthermore, it advocates for a synthesis of economic rationality with legitimacy gains and individual interests to elucidate the rationale behind the adoption of HR analytics.
Alleviating financial education debt through Zakah: proposing HOPE model to public higher education institution
Authors: Allah Pitchay Anwar , Abdul Rahman Masyitah , Azhar Zubir 
Published: December 2024

Purpose
This study aims to propose and validate the Holistic and Prosperous Education (HOPE) model to address the tertiary student loan burden of poor students in Malaysia’s public higher education.

Design/methodology/approach
This study employed an interpretivism paradigm to understand experts’ perspectives on the proposed HOPE model in higher education. Thus, the inductive approach is employed to better understand the research context and structure. The study uses a case study approach and interviews with four experts, covering information on the proposed HOPE model and respondents’ views on its practicability and validity.

Findings
The findings suggest a phased approach for disadvantaged students, aligning with Shariah’s objectives. Implementing the HOPE model at Malaysia’s local higher education (MLHE) could potentially catalyse transformative change within the higher education landscape. The HOPE model offers a promising alternative that harmonizes social responsibility, religious principles and institutional sustainability, addressing the persistent issue of student loan debt while fostering a more inclusive and prosperous educational environment.

Practical implications
The HOPE model can benefit students, educational institutions and the National Higher Education Fund Corporation (NEFC) financial sustainability. It emphasizes the responsible utilization of zakat funds and showcases its impact in addressing financial problems faced by students.

Originality/value
This study offers in-depth feedback from the various stakeholders, such as the top management of MLHE, NEFC and Shariah scholars, on the debt issues among tertiary students and the HOPE model proposed in this study to mitigate the loan burden problem among poor Muslim students.
Juvenile hormone induces phosphorylation of insulin/insulin‐like growth factor signaling proteins in previtellogenic Aedes aegypti mosquitoes
Authors: Zhao Wenhao , Liu Pengcheng , Saunders Thomas R. , Zhu Jinsong 
Published: December 2024

AbstractJuvenile hormone (JH) plays a pivotal role in regulating post‐emergence development and metabolism in previtellogenic female Aedes aegypti mosquitoes. In contrast, yolk protein precursor production and egg maturation after a blood meal are regulated by the steroid hormone 20‐hydroxyecdysone, the insulin‐like growth factor (IGF)/insulin signaling (IIS) pathway, and the mammalian target of rapamycin (mTOR) pathway. The role of IIS/mTOR signaling in female adults prior to blood feeding has not been thoroughly investigated. In this study, we identified a significant increase in the phosphorylation of key effector proteins in the IIS/mTOR signaling pathway, including eukaryotic translation initiation factor 4E‐binding protein 1 (4E‐BP1), ribosomal protein S6 kinase (S6K) and forkhead box protein O1 (FoxO1), in previtellogenic females. In vitro fat body culture experiments suggest that JH induces these phosphorylations through rapid nongenomic signaling mediated by the phosphatidylinositol 3‐kinase (PI3K)/protein kinase B (Akt)/mTOR network. RNA interference experiments demonstrated that activation of IIS/mTOR signaling in previtellogenic females modulate metabolic gene expression, promoting the accumulation of energy reserves (glycogen and triglycerides), which influence mosquito fecundity. Additionally, depletion of either the insulin receptor (InR) or the JH receptor Methoprene‐tolerant (Met) in adult mosquitoes abolished the phosphorylation of these proteins, indicating that both receptors are involved in JH‐induced membrane‐initiated signal transduction. Although the precise mechanisms remain unclear, this study uncovers a novel function of the IIS/mTOR pathway in adult mosquitoes before blood feeding, as well as a new mode of JH action through its crosstalk with the IIS pathway.
Insight Into Body Size Evolution in Aves: Based on Some Body Size–Related Genes
Authors: Luo Chaoyang , Xu Xionghui , Zhao Chengfa , Wang Qiuping , Wang Rongxing , Lang Datian , Zhang Juan , Hu Wenxian , Mu Yuan 
Published: December 2024

ABSTRACTBirds exhibit remarkable variations in body size, making them an ideal group for the study of adaptive evolution. However, the genetic mechanisms underlying body size evolution in avian species remain inadequately understood. This study investigates the evolutionary patterns of avian body size by analyzing 15 body‐size‐related genes, including GHSR, IGF2BP1, and IGFBP7 from the growth hormone/insulin‐like growth factor axis, EIF2AK3, GALNS, NCAPG, PLOD1, and PLAG1 associated with tall stature, and ACAN, OBSL1, and GRB10 associated with short stature, four genes previously reported in avian species: ATP11A, PLXDC2, TNS3, and TUBGCP3. The results indicate significant adaptive evolution of body size‐related genes across different avian lineages. Notably, in the IGF2BP1 gene, a significant positive correlation was observed between the evolutionary rate and body size, suggesting that larger bird species exhibit higher evolutionary rates of the IGF2BP1 gene. Furthermore, the IGFBP7 and PLXDC2 genes demonstrated accelerated evolution in large‐ and medium‐sized birds, respectively, indicating distinct evolutionary patterns for these genes among birds of different sizes. The branch‐site model analysis identified numerous positively selected sites, primarily concentrated near functional domains, thereby reinforcing the critical role of these genes in body size evolution. Interestingly, extensive convergent evolution was detected in lineages with larger body sizes. This study elucidates the genetic basis of avian body size evolution for the first time, identifying adaptive evolutionary patterns of body size‐related genes across birds of varying sizes and documenting patterns of convergent evolution. These findings provide essential genetic data and novel insights into the adaptive evolution of body size in birds.
Genomic Insights Into Genetic Basis of Evolutionary Conservatism and Innovation in Frogs
Authors: Zuo Bin , Chen Rongmei , Tang Xiaolong , Shao Yong , Liu Xiaolong , Nneji Lotanna M. , Sun Yanbo 
Published: December 2024

ABSTRACTExamining closely related species evolving in similar environments offers valuable insights into the mechanisms driving phylogenetic conservatism and evolutionary lability. This can elucidate the intricate relationship between inheritance and environmental factors. Nonetheless, the precise genomic dynamics and molecular underpinnings of this process remain enigmatic. This study explores the evolutionary conservatism and adaptation exhibited by two closely related high‐altitude frog species: Nanorana parkeri and N. pleskei. We assembled a high‐quality genome for Tibetan N. pleskei and compared it to the genomes of N. parkeri and their lowland relatives. Our findings reveal that these two Tibetan frog species diverged approximately 16.6 million years ago, pointing to a possible ancestral colonization of high‐elevation habitats. Following this colonization, significant adaptive evolution occurred in both coding and non‐coding regions of the ancestral lineage. This evolution led to notable phenotypic alterations, as evidenced by the reduced body size. Also, due to purifying selection, most ancestral adaptive features persisted in descendant species, indicating a strong element of evolutionary conservatism. However, descendant species evolved novel adaptations to exacerbated environmental challenges in the Tibet Plateau, mainly related to hypoxia response. Furthermore, our analysis underscores the critical role of regulatory variations in descendant adaptive evolution. Notably, hub genes in networks, such as EGLN3, accumulated more variations in regulatory regions as they were transmitted from ancestors to descendants. In sum, our study sheds light on the profound and lasting impact of genetic heritage on species' adaptive evolution.
Associations of combined accelerated biological aging and genetic susceptibility with incidence of heart failure in a population‐based cohort study
Authors: Zhao Hao , Zhang Xuening , Li Yanzhi , Wang Wanxin , Lai Wenjian , Zhang Wenjing , Kang Kai , Zhong Xiali , Guo Lan 
Published: December 2024

AbstractThe global aging population raises concerns about heart failure (HF), yet its association with accelerated biological age (BA) remains inadequately understood. We aimed to examine the longitudinal association between BA acceleration and incident HF risk, assess its modifying effect on genetic susceptibility, and how much BA acceleration mediates the impact of modifiable health behaviors on incident HF. We analyzed 274,608 UK Biobank participants without HF at baseline. Two BA accelerations (Biological Age Acceleration [BioAgeAccel] and Phenotypic Age Acceleration [PhenoAgeAccel]) were calculated by regressing clinical biomarker‐based BA on chronological age, with higher values indicating accelerated aging. Health behavior scores were computed based on diet, physical activity, tobacco/nicotine, sleep, and BMI. Genetic risk scores (GRS) were calculated by 12 HF‐associated loci. During a median follow‐up of 13.5 years, 8915 HF cases were documented. Each standard deviation increase in BioAgeAccel and PhenoAgeAccel was associated with an increased incident HF risk, yielding HRs of 1.45 (95% CI, 1.42–1.48) and 1.42 (95% CI, 1.40–1.45), respectively. Participants with high GRS and highest quartile of BioAgeAccel had an HR of 2.69 (95% CI, 2.42–2.99), and for PhenoAgeAccel, an HR of 2.83 (95% CI, 2.52–3.18), compared to those with low GRS, and lowest quartile. Additive interactions were observed between GRS and BA accelerations. Health behaviors reduced HF risk, with 21.1% (95% CI, 19.5%–22.8%) mediated by decreased BioAgeAccel and 20.9% (95% CI, 19.5%–22.6%) by decreased PhenoAgeAccel. Accelerated BA is associated with an increased incident HF risk, with an additive effect when combined with genetic susceptibility. Maintaining health behaviors may help mitigate BA aging and reduce HF risk.
Structural Unfairness or Disrespect and Misrecognition? Theorising the Pathway Between Feelings of Injustice and Collective Mobilisation Among Precarious Migrant Workers
Authors: Borello Andrea 
Published: December 2024

ABSTRACTIndustrial relations scholars have long been concerned with theorising collective mobilisation among workers, and it is well‐established that workers’ feelings of injustice can spark collective mobilisation. However, no attempts have to date been devoted to understanding how migrants experience feelings of injustice, although various other attempts have been made to theorise migrant worker collectivism. Through empirically founded field work in three sectors, this article contributes to theorise collective mobilisation among precarious migrant workers by combining Kelly's mobilisation theory with Tapia and Alberti's multi‐level approach to intersectionality. It starts from the premise that collective mobilisation begins with shared feelings of injustice and offers novel evidence to migrants’ experiences with injustice in contexts of intersecting precarity. Using a conceptual prism that distinguishes between restorative and retributive forms of justice, I show that although migrants are subject to distinct structural unfairness, they rarely ascribe retribute, class‐based struggles for justice as a cause for mobilisation. Rather, migrant workers mainly express feelings of injustice through disrespect and misrecognition resembling a restorative justice logic. These findings offer conceptual clarification to Kelly's mobilisation theory and can potentially move future research forward to a more nuanced understanding of the intersections between feelings, contexts of precarity and collective mobilisation.
The impact of post‐nephroureterectomy surgically induced chronic kidney disease on survival outcomes
Authors: Puri Dhruv , Meagher Margaret F. , Wu Zhenjie , Franco Antonio , Wang Linhui , Margulis Vitaly , Bhanvadia Raj , Abdollah Firas , Finati Marco , Antonelli Alessandro , Ditonno Francesco , Singla Nirmish , Broenimann Stephan , Simone Giuseppe , Tuderti Gabriele , Rais‐Bahrami Soroush , Moon Sol C. , Ferro Matteo , Tozzi Marco , Porpiglia Francesco , Amparore Daniele , Correa Andreas , Helstrom Emma , Gonzalgo Mark L. , Mendiola Dinno F. , Perdonà Sisto , Tufano Antonio , Eilender Benjamine M. , Mehrazin Reza , Yong Courtney , Ghoreifi Alireza , Sundaram Chandru P. , Djaladat Hooman , Autorino Riccardo , Derweesh Ithaar H. 
Published: December 2024

ObjectiveTo investigate the prevalence, predictors and impact of surgically induced chronic kidney disease (CKD‐S) on survival outcomes in patients with upper tract urothelial carcinoma (UTUC) following radical nephroureterectomy (RNU).MethodsUtilising the ROBUUST 2.0 registry, a multicentre retrospective analysis was conducted in patients with UTUC undergoing RNU between 2006 and 2022 who did not have baseline chronic kidney disease (CKD) stages 3–5. We calculated the prevalence of postoperative CKD‐S3a (estimated glomerular filtration rate [eGFR] 59–45 mL/min/1.73 m2) and CKD‐S3b (eGFR <45 mL/min/1.73 m2) as measured by the Chronic Kidney Disease Epidemiology Collaboration 2021 equation. The analytical cohort was stratified by postoperative CKD stage [no CKD‐S [eGFR ≥60 mL/min/1.73 m2]; CKD‐S3a [eGFR 59–45 mL/min/1.73 m2] and CKD‐S3b [eGFR <45 mL/min/1.73 m2]). The primary outcome was all‐cause mortality (ACM). Predictors for development of CKD‐S3a/3b and ACM/cancer‐specific mortality (CSM) were analysed using logistic and Cox regression, respectively. Kaplan–Meier analysis was used to analyse overall survival (OS) and cancer‐specific survival (CSS) among postoperative CKD groups.ResultsWe analysed 1862 patients; 34.7% (646) and 39.6% (738), respectively, developed CKD‐S3a and CKD‐S3b. Predictors of CKD‐S3b included increasing age (odds ratio [OR] 1.03, P = 0.029), decreasing preoperative eGFR (OR 1.06, P < 0.001) and receipt of neoadjuvant (OR 2.07, P = 0.006) and adjuvant chemotherapy (OR 1.41, P = 0.012). Worsened ACM was associated with CKD‐S3b (hazard ratio 1.42, P = 0.032), but not CKD‐S3a (P = 0.766). Development of CKD‐S3a (P = 0.812) and CKD‐S3b (P = 0.316) were not associated with CSM. The 5‐year OS rate was significantly worse in CKD‐S3b (no‐CKD 71%, CKD‐S3a 70%, CKD‐S3b 59%; P = 0.017). No differences between CKD‐S groups were noted for 5‐year CSS (no‐CKD 78%, CKD‐S3a 77%, CKD‐S3b 82%; P = 0.44).ConclusionsA significant proportion of UTUC patients undergoing RNU developed CKD‐S. Development of CKD‐S3b was associated with worse ACM. Increasing age, preoperative eGFR, and chemotherapy were associated with developing CKD‐S3b. Our findings call for further exploration and refinement of nephron‐preserving surgical strategies and non‐nephrotoxic systemic therapy to improve survival outcomes in UTUC.
Antitumor host immunity enhanced by near‐infrared photoimmunotherapy
Authors: Fukushima Hiroshi , Furusawa Aki , Okada Ryuhei , Fujii Yasuhisa , Choyke Peter L. , Kobayashi Hisataka 
Published: December 2024

AbstractNear‐infrared photoimmunotherapy (NIR‐PIT) is a novel antitumor therapy that selectively kills cancer cells by NIR light‐triggered photochemical reaction of IRDye700DX within Ab–photoabsorber conjugates (APCs). NIR‐PIT induces immunogenic cell death, causing immune cell migration between the tumor and tumor‐draining lymph nodes, and expanding multiclonal tumor‐infiltrating CD8+ T cells. Crucially, the cytotoxic effects of NIR‐PIT are limited to cancer cells, sparing immune cells such as antigen‐presenting cells and T cells, which are key players in boosting antitumor host immunity. By modifying the Ab used in APC synthesis, NIR‐PIT can be repurposed to target and deplete noncancerous immunosuppressive cells including regulatory T cells, myeloid‐derived suppressor cells, and cancer‐associated fibroblasts in the tumor microenvironment. Immunosuppressive cell targeted NIR‐PIT strongly potentiates antitumor host immunity, including the induction of abscopal effects and the development of immune memory. Furthermore, antitumor immune responses and therapeutic efficacy are synergistically enhanced when NIR‐PIT is combined with other immune‐activating treatments, such as interleukin‐15 and immune checkpoint inhibitors. These new findings make NIR‐PIT a valuable tool in the evolving landscape of cancer immunotherapy. This review explains the role of NIR‐PIT in activating antitumor host immunity.
Enhancing, Targeting, and Improving Dental Trauma Education: Engaging Generations Y and Z
Authors: Berlin‐Broner Yuli , Levin Liran 
Published: December 2024

ABSTRACTDental trauma is highly prevalent, involving 25% of school‐age children and about 12.5% of the general population of the world. Due to the young age of the patients that are usually involved in dental trauma, there are tooth‐related complicating factors, such as open apices, thin dentinal walls, and unfavorable crown‐to‐root ratio, as well as patient‐related factors, such as anxiety and cooperation, and other challenges related to the complex diagnosis and treatment. Therefore, it is not surprising that the global status of knowledge for the prevention and emergency management of traumatic dental injuries among dental professionals was often reported as insufficient. Aiming to improve dental trauma education, one should consider that the contemporary educational settings have transitioned to a digital learning ecosystem and that the current students belong to a unique generational cohort. Therefore, this paper examines the challenges educators encounter in contemporary dental school classrooms and the defining characteristics of current generation Y and Z dental student cohorts. Finally, it outlines strategies to optimize dental trauma learning, considering the unique generational characteristics of the current dental students.
Proustian Grief
Authors: Stern Thomas 
Published: December 2024

AbstractProust wrote vividly about grief, but he has not been recognised or studied as a philosopher of grief. It is time that he was. For a powerful and compelling philosophy of grief emerges from the pages of his magnum opus. Though philosophical work on Proust has not turned to this theory of grief, philosophers writing about grief have often drawn on Proust, both explicitly and implicitly, without an awareness of an underlying Proustian theory. This paper fills the gap by placing this philosophically informed, Proustian theory of grief before our eyes. Proust builds on contemporary discussions of habituation (habitude), the process whereby new sensations and new actions become both less salient, intrusive or demanding of our attention, and more crucial for our equilibrium and our continued short‐term functioning. Applying this to the social realm, Proust theorises love in terms of habituation to another person, and grief in terms of a sudden inapplicability or unsuitability of our habits to the world that person has left behind, followed by the painful, uneven and intermittent process of habituating to that new world. The paper explains this theory and charts its relation to some contemporary discussions of grief. Doing so places Proust back into a conversation he has already influenced.
Firm political risk and corporate social responsibility
Authors: Wang Shuhui 
Published: December 2024

AbstractWe explore the impact of political risk on firms' corporate social responsibility (CSR) and find a negative effect, especially on CSR strengths. Firms facing higher political risk tend to prioritize compliance‐driven CSR concerns over proactive CSR initiatives. This effect is more pronounced in firms with limited financial and operational flexibility, suggesting that CSR decisions align with overall investment strategies and are influenced by financial resources. We also show that political risk negatively affects CSR activities more during financial crises and gubernatorial elections. Overall, our study highlights the role of political risk and financial flexibility in shaping firms' CSR strategies.
Impact of high blood pressure on the risk of mortality among Japanese people aged 65 years and older
Authors: Akagi Shinsuke , Takao Soshi , Matsuo Rumi , Matsumoto Naomi , Yorifuji Takashi 
Published: December 2024

AimThe purpose of this study is to investigate the impact of abnormal blood pressure on the risk of all‐cause and cardiovascular mortality in a large cohort of older Japanese people aged ≥65 years.MethodsThis cohort study enrolled 54 760 participants from Okayama City aged ≥65 years who underwent basic health checkups from April 2006 to March 2008. Based on blood pressure, the participants were divided into six categories, from C1 (lowest) to C6 (highest). To assess the association of blood pressure with all‐cause and cardiovascular mortality, we used survival analysis to estimate hazard ratios (HRs) for all‐cause mortality and subdistribution HRs (SHRs) for cardiovascular mortality on C3. We then repeated the analyses based on age groups (65–74 years, 75–84 years, and ≥85 years).ResultsThe fully adjusted HRs for all‐cause mortality, which included all individual potential confounders, were 1.11 (95% confidence interval [CI]: 1.04–1.19) for C5 and 1.23 (95% CI: 1.09–1.38) for C6, respectively. The fully adjusted SHRs for cardiovascular mortality were 1.11 (95% CI: 1.01–1.21) for C4, 1.19 (95% CI: 1.05–1.34) for C5, and 1.36 (95% CI: 1.09–1.70) for C6. In the age‐stratification, an increased risk of hypotension was observed with older age. The HR for C1 was 1.28 (95% CI: 1.16–1.41) for ≥85 years.ConclusionsHypertension increased the risk of all‐cause and cardiovascular mortality among those aged 65–74 and 75–84 years, but not among those aged ≥85 years. Geriatr Gerontol Int 2025; 25: 82–89.