bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Preoperative Renal Replacement Therapy in Clinical Outcome of Heart Transplant Patients
Authors: Kim Darae , Choi Jin-Oh , Cho Yang Hyun , Cho Hyun Jai , Sung Kiick , Oh Jaewon , Jung Sung-Ho , Lee Hae-Young , Park Jin Joo , Choi Dong-Ju , Kang Seok-Min , Kim Jae-Joong , Jeon Eun-Seok 
Published: December 2020

Abstract
Although renal dysfunction is considered as a relative contraindication for heart transplantation (HTx), in real world, due to co-existing intrinsic renal dysfunction and/or cardiorenal syndrome, many patients with advanced heart failure (HF) experience worsening of renal function and some even require renal replacement therapy (RRT) by the time they undergo HTx We aimed to investigate the prognosis and clinical outcomes of heart transplant (HTx) patients who required renal replacement therapy (RRT) during the perioperative period.The Korean Organ Transplant Registry (KOTRY) is a nationwide organ transplant registry in Korea. A total of 501 HTx patients had been prospectively enrolled in the KOTRY registry during 2014-2018. Among the 501 patients, 13 underwent combined heart and kidney transplantation (HKTx). Patients who underwent isolated HTx were grouped according to their pre and postoperative RRT status. The primary outcome was progression to dialysis-dependent end-stage renal disease (ESRD) after HTx. The secondary outcome was all-cause mortality after HTx. The median follow-up was 22 months (9–39 months). Patients who needed preoperative RRT but free from postoperative RRT showed comparable overall survival and renal outcome to patients who were free from both pre and postoperative RRT. From multivariable analysis, preoperative RRT was not associated with progression to ESRD or all-cause mortality after HTx, however, postoperative RRT was a significant predictor for both progression to ESRD and all-cause mortality after HTx. Preoperative creatinine or estimated glomerular filtration rate (eGFR) were not predictive of progression to ESRD after HTx. The present analysis suggests that preoperative RRT requirement does not indicate an irreversible renal dysfunction in patients waiting for HTx. The survival and renal outcome was comparable to those who did not need perioperative RRT when renal function recovered after HTx. However, postoperative RRT was associated with progression to ESRD and mortality after HTx.
Depression and Excitation of Buneman’s Instability in Two Ions Species Magnetized Dusty Plasma
Authors: Alyoussef Haifa 
Published: December 2020

Abstract
In this research, theoretical method was used to examine the excitation and depression state for two-stream Buneman’s instability (BI) when we assumed an inhomogeneous, anisotropic, multi ions species with the presence of dust grains in plasma. The plasma also studied at different temperatures state. The diffusion equation was also derived and solved in one dimension for the Buneman’s instabilities that arise in such a situation within plasma. We develop the single-ion theory into a multiple-ion-species theory. This study concluded that: degree of plasma inhomogeneity, electron to ions temperature ratio, multi ions species and dust grains which have thermal velocity play a very important role in the depression and excitation of instability such Buneman’s instability.
New Recommendations for Robertsonian Translocation Management After Preimplantation Genetic Testing of Structural Rearrangement (PGT-SR) Attempts: What Should Be Done With Mosaic Embryos?
Authors: Zenagui Reda , Bernicot Izabel , Ciabrini Cendrine , Hoa Alice Ferrieres , Castelli Christel , Ranisavljevic Noemie , Anahory Tal 
Published: December 2020

Abstract
Robertsonian translocation (RT) carriers are phenotypically normal, but they are known to be at increased risk of repeated miscarriages compared with the general population estimated at about 15% of pregnancies, and also resulting in the birth of a child with a mental retardation or congenital anomalies. Preimplantation Genetic Testing (PGT) is therefore a solution for RT carriers. An appropriate probe strategy allows to differentiate balanced embryos, unbalanced embryos, and mosaic embryos. We performed the first comparative analysis between two or three probes FISH strategies to analyze if a probe strategy choice for PGT-SR studies of Robertsonian translocations (RT) influences the fate of embryos? Our investigations present 13 years of experience of PGT for Robertsonian translocation carriers to improve the accuracy of abnormality detections. A deeper analysis of 283 PGT-SR attempts by comparing two strategies of probes highlighted the irrelevance of using a third probe for FISH diagnosis and above all a significant difference of mosaic embryo rates between probe strategies. These findings could be used as new recommendations of Robertsonian translocation management in many laboratories to improve their practices. It could be readily run, less expensive, reliable and accurate. Furthermore, the propounded strategy of mosaic embryo transfer should be considered after a detailed genetic counseling.
Characterization of A Murine Model of Endothelial Dysfunction Induced by Chronic Intraperitoneal Administration of Angiotensin II
Authors: Trejo-Moreno Celeste , Jiménez-Ferrer Enrique , Castro-Martínez Gabriela , Méndez-Martínez Marisol , Santana María Angélica , Arrellín-Rosas Gerardo , Pedraza-Chaverri José , Medina-Campos Omar , Hernández-Téllez Beatriz , Barrita-Cruz Joel , Ramírez-Pliego Oscar , Herrera-Ruíz Maribel , Fragoso Gladis , Rosas-Salgado Gabriela 
Published: December 2020

Abstract
Endothelial dysfunction (ED) is a key factor for the development of cardiovascular diseases. Due to its chronic, life-threatening nature, ED only can be studied experimentally in animal models. Therefore, this work was aimed to characterize a murine model of ED induced by a daily intraperitoneal administration of angiotensin II (AGII) for 10 weeks. Oxidative stress, inflammation, vascular remodeling, hypertension, and damage to various target organs were evaluated in treated animals. The results indicated that a chronic intraperitoneal administration of AGII increases the production of ROS, ICAM-1 expression, the production of TNFα, IL1β, IL17A, IL4, TGFβ, and IL10, as well as blood pressure levels; it also promotes vascular remodeling and induces non-alcoholic fatty liver disease, glomerulosclerosis, and proliferative retinopathy. Therefore, the model herein proposed can be a representative model for ED; additionally, it is easy to implement, safe, rapid, and inexpensive.
Oral Health Related Quality of Life in Patients Infected With HIV, IRAN: A Cross Sectional Study
Authors: Shaghaghian Soheila , Saranjam Elham , Mojtaba Homayooni 
Published: December 2020

Abstract
Background: In recent years, life expectancy of patients with Human Immunodeficiency Virus (HIV) increased. They experienced oral manifestations that could affect their Oral Health Related Quality of Life (OHRQoL). This study was conducted to evaluate OHRQoL in the patients and its related factors. Methods: In this cross-sectional study, using simple random sampling, we selected 250 patients with HIV from Shiraz Voluntary Counseling and Testing center in 2019. To evaluate their OHRQoL, we used Geriatric Oral Health Assessment Index revised for patients with HIV. We assessed the association between the patients' OHRQoL and demographic characteristics. Results: The mean score of the patients' OHRQoL was 24.50±6.25. The worst and the best scores were in psychosocial and pain categories, respectively. In univariate analysis, the OHRQoL significantly associated with the patients' age (p=0.005), duration of disease (p=0.008), job (p=0.010), edentulous status (p=0.002), and wearing denture (p<0.001). However, in multiple linear regression analysis, we found only a significant difference between participants wearing and not wearing denture (p=<0.001).Conclusions: The participants declared that they satisfied from averagely 70% of items of OHRQoL. The OHRQoL was significantly better in the patients wearing denture. The finding highlighted the importance of fulfillment of dental needs on improving OHRQoL. Therefore, planning of dental services for patients with HIV is essential so that they have timely access to oral health care. Furthermore, authorities should consider denture as an unmet need in the patients and provide facilities to help the patients to become denture owners.
A Randomized Clinical Trial Protocol, Parallel-Group Study to Determine the Effect of Cognitive-Behavioral Therapy on Family Violence and Its Consequences in Transgender Youth.
Authors: Damanpak-Rizi Mahdieh , Farnam Farnaz , Khodakhah Parisa 
Published: December 2020

Abstract
BackgroundFamily violence against transgender people is a common issue and affects their mental health. Very few if any interventions have been designed to reduce family violence against transgender youths. This RCT will evaluate the efficacy of cognitive-behavioral therapy for transgender’s parents on their violent behavior towards their children and on transgender youth’s mental health.MethodsThis study is a randomized controlled trial that will be conducted on 50 transgender youths with selected inclusion criteria in Iran. Intervention will be undertaken on the parents or guardians of these transgender youths, in eight 1-hour online sessions for intervention group to increase their knowledge of gender dysphoria, to help control their anger regarding their offspring’s gender dysphoria and to learn manage stressful situations. Primary outcomes that will be measured in this study include frequency of family violence towards transgender youths, depression, anxiety, stress, self-esteem, suicidal thoughts and suicide attempts in transgender youth and secondary outcome is parental conflict resolution tactics before and after intervention.DiscussionTo the best of our knowledge, this is the first RCT on family violence against transgender youth in world and in Iran. Findings will help to provide better education for transgender’s parents to reduce violence against their children.ResultsN/AConclusionN/ATrial registrationIR.TUMS.FNM.REC.1398. 201 , 2020-03-08
Microbial’s Effects on Invasive Grass’ Response to Water and Nutrient Stress
Authors: Zhang Bo , Yuan Yingdan , Pajerowska-Mukhtar Karolina M. , Afkhami Michelle , Hastings Alan , Qiu Jiangxiao , Zhang JInchi 
Published: December 2020

Abstract
Background Soil microbiomes play important roles in invasion biology, yet it is often treated as a ‘black box’ in modeling or large-scale field studies. Hence, investigating the change of association between invasive vegetation and soil microbes under changing environmental conditions, and exploring the genetic functions of associated microbiomes will provide a deeper understanding of invasion mechanisms. We performed a microcosm experiment with cogongrass (Imperata cylindrica (L.) P. Beauv.), which is one of the 100 worst invasive plants in the world. We combined rigorous sequencing analysis, including 16S rRNA, ITS, and shotgun metagenome sequencing, for the first time, to investigate the interactive effect of change in soil water and nutrient concentrations on microbiomes diversity, composition and genetic functions under invasion. Results We found that experimental drought has a stronger effect on the bacterial community than the fungal community. We discovered an enrichment of microbial groups, including Proteobacteria, Actinobacteria, Bacteroidetes and Chloroflexi under drought treatment, could likely contribute to invasion success. Further, we showed a striking trend of induction of cell wall, membrane and desiccation-related genes in drought treatment and a marked downregulation in regular treatment, which could create a more hydrated microenvironment, facilitating biofilm formation and better protection from desiccation.Conclusions Our work contributes to highlighting the associated microbial communities may have a potential long-term impact on increasing cogongrass drought resistance, ultimately, future invasion might be severe due to the plant-microbe interaction. These findings are important because current modeling practice, lacking comprehensive consideration of the plant-microbe interaction, could lead to a significant underestimate of predictions of future invasion patterns.
B cell Activity and anti-MBP Autoantibody Response to Peripheral Nerve Injury is Sexually Dimorphic
Authors: Lee Hee Jong , Remacle Albert , Hullugundi Swathi , Dolkas Jennifer , Leung Jake , Chernov Andrei , Yaksh Tony , Strongin Alex , Shubayev Veronica 
Published: December 2020

Abstract
Background: Autoantibodies, a hallmark of autoimmune disorders, are thought to contribute to the pathogenesis of chronic pain. Mechanical hypersensitivity is a severe complication of peripheral nerve injury mediated through sex-specific activity of immune and glial cells. Whether B cell contribution to nerve injury and pain is sexually dimorphic remains unknown. Methods: CD20 immunoblotting and immunostaining was conducted in female and male sciatic nerve after chronic constriction injury (CCI). B cell/CD20 targeting by bolus intravenous (IV) Rituximab or control immunoglobulin (IVIG) therapy or vehicle was administered in female and male rats post-CCI, followed by von Frey mechanical sensitivity testing. The cryptic myelin basic protein (MBP) epitopes were identified by immunostaining (EMD-AB5864 Millipore antibody) in female and male CCI nerves. ELISA was used to detect serum autoantibodies against the immunodominant MBP(84-104) epitope was conducted in female and male rats post-CCI. Results: Infiltration of CD20-positive cells, presumably B cell, was observed in female and male nerve at one week post-CCI. A single bolus IV anti-CD20/Rituximab therapy at one week post-CCI reduced the degree of mechanical hypersensitivity in female, but not in male, rats. IVIG therapy and vehicle treatment had no effect in either sex. Sustained release of the cryptic MBP epitopes from myelin was observed in nerves post-CCI in both sexes. Remarkably, serum anti-MBP(84-104) autoantibody was detected in female, but not in male, rats post-CCI. Conclusions: B cell activity and autoantibody production after peripheral nerve injury are sexually dimorphic. In females, mechanical hypersensitivity arising due to autoimmune remodeling of myelin on sensory neuraxis is amenable to immunotherapeutic intervention.
The Associations Between Blood Pressure and Quality of Life in Elderly Patients&nbsp;with Hypertension in China
Authors: Cui Lingling , Wu Wenya , Qi Jindan , Ojo Omorogieva , Jin Xiaohong , Liu Yuanyuan , Wang Xiaohua 
Published: December 2020

Abstract
Objective: To investigate the status of quality of life (QOL) and examine the changes in quality of life with increasing age in elderly patients with hypertension; to determine the associations between blood pressure and quality of life in hypertensive elderly at different age groups; to determine the relationships between ranges of blood pressure and quality of life. Method: This was a cross-sectional study design. The study recruited 752 elderly patients with hypertension from one general hospital, thirty urban community clinics and rural clinics in Suzhou from October 2016 to October 2017.The quality of life was assessed by The Short Form Health Survey (SF-36), which is categorized into two aggregate summaries, including physical component summary (PCS) and mental component summary (MCS). Furthermore, PCS included four dimensions, namely; physical functioning (PF), role limitation because of physical health (RP), bodily pain (BP) and general health perceptions (GH); MCS included another four dimensions, namely; vitality (VT), social functioning (SF), role limitation because of emotional health problems (RE) and mental health (MH). Result: The result showed that scores of physical component summary (PCS) gradually decreased and scores of mental component summary (MCS) was stable with increasing age. In PCS, the scores of the bodily pain and physical functioning dimensions and in MCS the social functioning dimension score dropped in participants with age ≥ 85 years. Following analysis, the results showed that diastolic blood pressure (DBP) was positively associated with PCS (r=0.112, P =0.003). We further analyzed the relationship between DBP and PCS (including 4 dimensions) of quality of life at different age groups. We found that DBP had a positive relationship with PSC (r=0.114, P =0.003) and the bodily pain dimension (r=0.205, P < 0.001) in the elderly with an age < 85 years, while there was no relationship between DBP and PCS in the elderly with an age ≥ 85 years. After adjusting for the effects of socio-demographic and clinical factors, there was no association between DBP and PCS (B=0.026, P= 0.633), while DBP still had a positive effect on the bodily pain dimension (B=0.234, P= 0.026). Conclusions: We found that DBP had a positive relationship with physical quality of life in the elderly with age < 85 years.Therefore, medical personnel should maintain the DBP within normal range but may allow higher level, when managing hypertensive elderly patients aged < 85 years, so as to relieve their pain, which can help improve their quality of life.
Study on the Seismic Performance of Small-diameter Bolts Reinforced in Grottoes
Authors: Peng Ningbo , Sun Bo , Huang Jizhong , Dong Yun , Zhu Ye 
Published: December 2020

Abstract
The Yungang Grottoes, a World Heritage Site in Datong, consist of 252 caves that are noted for their collection of 5th and 6th century Buddhist grotto sculptures and reliefs. Various diseases have appeared in the grottoes under the general influence of natural and artificial factors. Bolt support is a commonly employed method for grotto reinforcement and has been widely applied in many projects. Small-diameter bolts have also been used in the reinforcement projects at the Yungang Grottoes, but the corresponding effect on the seismic performance of grottoes is still unclear. In this paper, a dynamic analysis via the numerical modelling of an ear grotto of the 19th grotto in Yungang was established, and the rock displacement, acceleration and bolt axial force responses under a seismic wave are analyzed. The results show that the seismic dynamic responses of grottoes are greatly affected by the cliff structure. The displacement and acceleration responses of the cliff body vary greatly within the abrupt transition of the cliff structure. Based on this variation, the seismic capacity of small-diameter bolts in the vertical direction is greater than that in the horizontal direction. The axial force of a bolt is small at both ends of the bolt, large in the middle of the bolt, small on the top of a cliff and large at the bottom of the cliff. Although the axial force is small, the upper rock mass of the grotto has a tendency to undergo relative movement compared with the outer rock mass. The results also indicate that based on the structural defects in the vertical direction of the cliff body caused by grotto excavation, the inclined angle of the bolt should be increased as far as possible or vertical support should be adopted to enhance the stability of the rock mass at the top of the grotto.
Clinical Evidence of Vestibular Dysregulation in Colicky Babies Before and After Chiropractic Treatment Versus Non-Colicky Babies.
Authors: Hoeve Jan 
Published: December 2020

Abstract
BackgroundAfter 65 years of research that has been primarily directed at differentiating between normal and colicky crying, the cause of infantile colic remains elusive and no definitive cure has been found. Given the general absence of pathology, colicky crying is widely considered the extreme end of a spectrum of normal crying behavior. In the literature scattered evidence can be found suggesting that infantile colic may be the behavioral expression of physiological brainstem dysregulation, particularly of the vestibular and autonomic nuclei. The purpose of this study is to present a five-point clinical index of vestibular (hyper)activity and its application to investigate vestibular dysregulation in colicky and non-colicky babies.Methods120 consecutive colicky babies were evaluated using this index, before and after a very gentle vibratory treatment, and compared to 117 non-colicky babies.ResultsBefore treatment, of 120 colicky babies only 2 (1.7%) scored 0, whereas 118 (98.3%) scored scored 1-5. Of 117 non-colicky babies 89 (76,1%) scored 0 and 28 (23.9%) scored 1-3, none scored 4-5. The odds ratio is OR (CI 95%) 187.54 (43.52-808.09). After treatment 111 (92.5%) scored 0 and 9 (7.5%) scored 1-3, none scored 4-5. A McNemar test showed the difference before and after to be significant (χ² = 109.00, p < .001). For colicky babies the mean vestibular score is 2.88(SD 1.22), compared to 0.37(SD 0.73) for non-colicky babies, a difference of 87.2%. After treatment the score decreased from 2.88 (SD 1.12) to 0.10 (SD 0.40), or 96.5%. ConclusionColicky babies are not just infants who cry a lot. They also show clinical evidence of vestibular dysregulation. Gentle treatment aimed at relaxing tight sub-occipital musculature by means of a vibrational technique may be effective in decreasing vestibular hyperactivity, signifying an improvement in brainstem regulation. The vestibular index opens the prospect for development into a tool towards an objective and practical clinical diagnosis of infantile colic.
Effectiveness of Feeding Supplementation in Preterm Infants: An Overview of Systematic Reviews
Authors: Tao Jiaxin , Yang Jixin , Li Yufeng , Su Yanwei , Mao Jing 
Published: December 2020

Abstract
BackgroundPreterm infants have higher nutrition needs than term infants. The effectiveness of various feeding supplementation was assessed by the improvement of health outcomes in single specific systematic reviews (SRs). The aim of this review is to summarise these SRs to provide comprehensive evidence on the effectiveness of these interventions for preterm infants. MethodsA literature search was conducted in the PUBMED, EMBASE, Science Direct, Cochrane library, Web of Science, and Wiley online library. SR selection followed clear inclusion and exclusion criteria. Data extraction was performed by using the pre-designed tables and quality assessment was done by the AMSTAR tool. ResultsSeventeen SRs were included in the review. Fifteen kinds of feeding supplementation were reported in the SRs. The effectiveness of the interventions was defined as positive, having no impact, or inconclusive. Lactoferrin, probiotic, prebiotic, vitamin D, protein, and arginine were concluded to be positive; inositol, iodine, fat, glutamine, and long chain polyunsaturated fatty acid (LCPUFA) were concluded to have no impact; results for prebiotic (for prevention of hyperbilirubinaemia), carbohydrate, multi-nutrient, taurine, calcium, and phosphorus were inconclusive. All the SRs included were graded as being of high quality. ConclusionsSupplements with positive effects on health improvement were considerable to add to the feeding of preterm infants. More well-designed large RCTs are still needed to address the unsolved problems in the SRs concluded as having no impact or where the results were inconclusive.