bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health care use and treatment-seeking for depression symptoms in rural India: A descriptive cross-sectional analysis
Authors: Roberts Tessa Naomi , Shidhaye Rahul , Patel Vikram , Rathod Sujit D 
Published: December 2019

Abstract
Background There is a large “treatment gap” for depression worldwide. This study aimed to better understand the treatment gap in rural India by describing health care use and treatment-seeking for depression. Methods Data were analysed from a two round cross-sectional community survey carried out in rural Madhya Pradesh between May 2013 and December 2016. We examined the proportion of individuals with probable depression who sought treatment in different sectors, for depression symptoms and for any reason, and compared the latter with health service use by non-depressed individuals. We showed the frequency with which barriers to healthcare utilisation were reported by adults with probable depression, and examined differences in the proportion of adults who sought treatment for depression by predisposing, enabling and need factors. Results 86% of adults with probable depression reported seeking no depression treatment. However, 66% had used health services for any reason in the past 3 months, compared to 46% of those without depression (p<0.0001). Private providers were most frequently consulted by adults with probable depression (32%), while only 19% consulted traditional providers. Structural barriers to healthcare use such as cost and distance to services were frequently reported (54% and 52%, respectively) but were not associated with treatment-seeking for depression. The following factors were found to be positively associated with treatment-seeking for depression: higher symptom severity; reporting lack of energy, lack of interest/pleasure, low self-esteem, or slow movements/restlessness on more than 7 days in the past 2 weeks; being married; having discussed depression symptoms; and reporting problems with medication availability and supply as a barrier to healthcare. No evidence was found for an association between treatment-seeking for depression and most socio-economic, demographic or attitudinal factors. Discussion and conclusions The majority of adults with probable depression actively seek healthcare, but not specifically for depression symptoms, indicating the need to improve detection of depression during consultations about other complaints. Private providers should be included in programmes to improve the detection and treatment of depression. Unmarried individuals may experience greater difficulties in accessing care in this setting. Further research should test the hypotheses generated in this descriptive study.
Exposure to Baby-Friendly Hospital Practices and Mothers’ Achievement of their Planned Duration of Breastfeeding.
Authors: Lok Kris Y.W. , Chow Charlotte L.Y. , Fan Heidi S.L. , Chan Vincci H.S. , Tarrant Marie 
Published: December 2019

Abstract
Background: Both breastfeeding intentions and exposure to baby-friendly hospital practices have been associated with a longer duration of breastfeeding. This study aims to examine the effect of exposure to baby-friendly hospital practices on mothers’ achievement of their planned duration of breastfeeding. Methods: A total of 1011 mother-newborn pairs from the postpartum units of four public hospitals in Hong Kong were recruited. Sociodemographic data and breastfeeding intention data were collected via self-report questionnaires during the postnatal hospitalization and exposure to Baby-Friendly hospital practices were assessed through hospital records and maternal self-report. Breastfeeding status after hospital discharge was assessed through telephone follow-up for up to 12 months postpartum, or until participants were no longer breastfeeding. Results: Only 55% (n=552) of study participants achieved their intended duration of breastfeeding. Participants with higher socioeconomic status, previous breastfeeding experience, and those who had lived in Hong Kong for less than 5 years, were more likely to achieve their planned duration of breastfeeding. Among baby-friendly hospital practices, feeding only breast milk during the hospitalization and providing information about breastfeeding support on discharge were associated with participants’ achieving their individual breastfeeding intentions. After adjustment, when compared with women who experienced 0 - 1 baby-friendly practice, participants who experienced six baby-friendly hospital practices were significantly more likely to achieve their planned duration of breastfeeding (adjusted odds ratio=8.45, 95% confidence interval 3.03 – 23.6). Conclusions: Nearly half of participants did not achieve their planned breastfeeding duration. Exposure to baby-friendly hospital practices, especially in-hospital exclusive breastfeeding and providing breastfeeding support information upon hospital discharge may help more mothers to achieve their individual breastfeeding goals.
The Data‐Intensive Farm Management Project: Changing Agronomic Research Through On‐Farm Precision Experimentation
Authors: Bullock David S. , Boerngen Maria , Tao Haiying , Maxwell Bruce , Luck Joe D. , Shiratsuchi Luciano , Puntel Laila , Martin Nicolas F. 
Published: December 2019

The Data‐Intensive Farm Management (DIFM) project works with participating farmers, using precision technology to inexpensively design and run randomized agronomic field trials on whole commercial farm fields, to provide data‐based, site‐specific farm input management guidance, thus providing economic and environmental benefits. This article lays out a conceptual framework used by the multidisciplinary DIFM research team to facilitate collaboration and then presents details of DIFM's procedures for what it calls on‐farm precision experimentation (OFPE), which includes field trial design and implementation, data generation, processing, and management, and analysis. It is argued that DIFM's data and the agricultural “Big Data” currently being collected with remote and proximal sensors are complementary; that is, more of either increases the value of the other. In 2019, DIFM and affiliates conducted over 120 trials, ranging from 10 to 100 ha in size, on maize, wheat, soybeans, cotton, and barley in eight US states, Argentina, Brazil, and South Africa. The DIFM is developing cyberinfrastructure to “scale up” its activities, to permit researchers and crop consultants worldwide to work with farmers to conduct trials, then process and manage the data. In Addition, DIFM is in the early stages of developing a software system for semi‐automatic data analytics, and a cloud‐based farm management aid, the purpose of which is to facilitate conversations between agronomists and farmers about implementing data‐driven input management decisions. The proposed framework allows researchers, agronomists, and farmers to carry out on‐farm precision experimentation using novel digital tools.Core Ideas

The Data‐Intensive Farm Management project's on‐farm trials can generate massive amounts varied managed input data.
The Data‐Intensive Farm Management project's data fill a gap in agricultural “Big Data,” to enable data‐intensive crop management.
The Data‐Intensive Farm Management project's protocols support trial design, data processing and analysis.
The Data‐Intensive Farm Management project can be implemented by researchers, consultants, and farmers in diverse agronomic scenarios.
Effect of the Frictional Properties of Sunflower Seeds on the Efficiency of Pressing Equipment
Authors: Berezin Mihail , Borisov Vitaly 
Published: December 2019

Introduction. The process of oil extraction from oilseeds is very complicated as it depends on a large number of related factors. The complex porous structure of pulp is a combination of three phases: dry solids, liquid (oil), and air. Therefore, the study of the process of pulp pressing requires a special method for determining the friction characteristics of the material.
Study objects and methods. To determine the friction and volume characteristics of oilseeds, an original experimental unit was developed and manufactured. The study involved samples of the same mass weighted using a high-accuracy analytic balance (permissible error = ± 5%). The first stage of the experiment featured volume characteristics of ten samples. The second stage featured friction characteristics of the five first samples obtained during the first stage at different pressures.
Results and discussion. The pressure time proved to have a more significant effect on the oil yield than the pressure volume, since the complex capillary structure of the pulp demonstrated a significant hydrodynamic resistance to oil outflow. The dependence of the oil yield on the pressure was described by an asymptotic function; the limit (asymptotic) value of the pressure was 48 MPa. At this pressure, the oil yield reached φ = 54 %. The dependence of the friction coefficient on the values of temperature, pressure, and sliding velocity was described by a power-law regression equation with the coefficient of accuracy of approximation R2 = 0.96.
Conclusion. The obtained data are of practical importance and can be used to improve the efficiency of pressing equipment.
Comparative Analysis of the Glycemic Index of Amaranth and Other Gluten-Free Products
Authors: Urubkov Sergey , Khovanskaya Svetlana , Smirnov Stanislav 
Published: December 2019

Introduction. For patients with gluten intolerance, diet therapy is the main method of treatment. However, gluten-free diets are found lacking in many important components. Children that fail to consume neccessary nutrients or have problems with their absorption tend to be physically retarded. Gluten-free diet may increase the risk of autoimmune diseases, especially type I diabetes. Therefore, products for children with celiac diseases should be both gluten-free and have adequate bioavailability of carbohydrates. This article features the chemical composition of amaranth, the geometric structure of starch grains, and its effect on the formation of colloidal solutions. It also compares the glycemic index (GI) of amaranth with other gluten-free grains, i.e. rice, buckwheat, and corn.
Study objects and methods. The research featured native amaranth grain (Amaranthus cruentus) (Mexico), puffed amaranth kernels (Mexico), and coarse granular amaranth flour (Mexico).
Results and discussion. Amaranth grain contains 12.5–23% of protein, 50.7–77.0% of carbohydrates, 6.0–8.0% of lipids, 10.5–18.3% of dietary fiber, and 2.5–3.5% of minerals. The GI of amaranth and its products were compared with similar values of other glutenfree crops, namely rice, buckwheat, and corn. Amaranth grain and its products demonstrated a higher GI, if compared with other gluten-free grain raw materials. The GI of amaranth grain was 87, the GI of the puffed amaranth kernels was 101, and the GI of the coarse granular amaranth flour was 97. Amaranth starch is easy to digest, which is mainly due to the high content of amylopectin (88 to 98%), since amylopectin breaks down faster than amylose. The relatively small size of starch granules (1.5–3.0 microns) increases the attack capacity of enzymes. These properties make amaranth starch glycemic, or low-resistant, which means that amaranth is easily digested and possesses stability to retrogradation.
Conclusion. The unique nutritional and functional properties of amaranth gluten-free products can significantly improve the diet of children with gluten intolerance. However, amaranth starch and its products have a high GI. Hence, it is necessary to control the percentage of these components in formulations and be careful with the selection of additional components and their impact on the total GI.
Hogares guatemaltecos y etnicidad en el sur de México: perfiles demográficos y socioeconómicos
Authors: Vargas Valle Eunice D. , Rodríguez Chávez Oscar , Rodríguez López María Teresa 
Published: December 2019

El objetivo general de este artículo es analizar los perfiles demográficos y socioeconómicos de los hogares guatemaltecos por habla de lengua indígena en las entidades de la frontera sur de México. En particular, se explora cuántos hogares guatemaltecos están asentados, cómo se configuran y cómo se han integrado en términos estructurales, con base en la Encuesta Intercensal 2015. Para tal fin se emplea estadística descriptiva y un modelo de regresión logística multinomial. El análisis indica que los hogares guatemaltecos se concentran en áreas rurales, son numerosos y más jóvenes, y laboran principalmente en el sector primario. Su integración socioeconómica es desventajosa en rubros como las condiciones del empleo y de la vivienda y el acceso a servicios sociales. No obstante, los hogares guatemaltecos indígenas exhiben niveles más altos de integración social que sus contrapartes no indígenas en el acceso a la ciudadanía mexicana, vivienda y apoyos económicos gubernamentales.
Design, Synthesis, Molecular Modeling and Anti-HIV Assay of Novel Quinazolinone Incorporated Coumarin Derivatives
Authors: Safakish Mahdieh , Hajimahdi Zahra , Aghasadeghi Mohammad R. , Vahabpour Rouhollah , Zarghi Afshin 
Published: December 2019

Background:
The emergence of drug-resistant viral strains has created the need for the
development of novel anti-HIV agents with a diverse structure that targets key enzymes in the HIV
lifecycle.

Objective:
Considering the pharmacophore of integrase inhibitors, one of the validated targets for
anti-HIV therapy, we designed a quinazolinone incorporated coumarin scaffold to affect HIV.

Method:
Coumarin is a beta enol ester and also a well-known drug scaffold. Designed structures
were prepared using a one-pot three-compo

Results:
In vitro anti-HIV and cytotoxicity assay indicated that more than half of the compounds
had EC50 values lower than 50 µM. Unsubstituted phenyl derivative showed the highest activity and
selectivity with an EC50 value of 5 µM and a therapeutic index of 7. Compounds were docked into
the integrase active site to investigate the probable mechanism of action. Accordingly, the hydroxyl
moiety of coumarin along with the carbonyl of the quinazolinone ring could function as the metal
chelating group. Quinazolinone and phenyl groups interact with side chains of IN residues, as well.

Conclusion:
Here, a novel anti-HIV scaffold is represented for further modification and in-vivo
studies.
Network Pharmacology Approach Uncovering Pathways Involved in Targeting Hsp90 Through Curcumin and Epigallocatechin to Control Inflammation
Authors: Umme Hani  , Kandagalla Shivananda , B.S. Sharath , K. Jyothsna , Hanumanthappa Manjunatha 
Published: December 2019

Aims:To fetch pathways involved in targetting Hsp90 through Curcumin and Epigallocatechin through Network pharmacological approach.Background:Hsp90 is a molecular chaperone involved in stabilizing inflammatory protein which may lead to chronic diseases. The herbal compounds Curcumin and Epigallocatechin processing antiinflammatory properties are known to follow a common pathway and control the expression of Hsp90.Objective:To collect the gene targets of Hsp90, Curcumin and Epigallocatechin in order to understand protein-protein interactions of gene targets by constructing the interactome to identify the hub proteins. Hub proteins docking was performed with curcumin and epigallocatechin. Finally, hub proteins involvement with various human diseases were identified.Methods:The gene targets of Hsp90, Curcumin and Epigallocatechin were obtained from there respective databases. Protein-protein interactions of Pkcδ-Nrf2 and Tlr4 pathway gene targets were collected from String database. Protein interaction network was constructed and merged to get intercession network in cytoscape and Cluego was used to predict the disease related target genes. Docking of ligands to target proteins was carried out using Autodock vina tool.Results:The main key regulators of Curcumin and Epigallocatechin were identified particularly from Pkcδ-Nrf2 and Tlr4 pathway.Conclusion:The combined action of Curcumin and Epigallocatechin can reduce the expression of Hsp90 eventually controlling the inflammation.
Severe OSA Leading to Long Pauses in 24-h Holter ECG Reversed with CPAP
Authors: Mukhopadhyay Mainak , Roy Sayak , Bera Mridul , Bhattacharya Guruprasad 
Published: December 2019

Introduction:
Sleep-related problems like sleep apnea are increasing tremendously
mostly owing to the disordered lifestyle the present generation is leading which is added like a topping
on the base of obesity and metabolic syndrome. The burden on the society is huge taking into
consideration the work-time loss and health-related financial issues arising out of these sleep disorders
with obstructive sleep apnea (OSA) leading the way. Early diagnosis can prevent several complications
of OSA. Cardiovascular diseases, including various arrhythmias, arising due to OSA, are
described previously.

Case Presentation:
Herein, an interesting case of OSA, whose pacemaker installation to rectify the
long pause could be avoided by simple correction of his OSA using continuous positive airway
pressure, is presented. This 49-year-old male patient was diagnosed with severe OSA by using
polysomnography and all his significant sinus pauses (highest one with 7.8 sec) during holter ECG
monitoring were found to be occurring at night and correcting his OSA with continuous positive
airway pressure (CPAP) treatment reverted all those sinus pauses and the need for any further intervention
with pacemaker was discarded.

Discussion:
OSA is caused by either partial or complete obstruction of the upper airway, and there
is the simultaneously attenuated upper airway dilator muscle tone while the patient is sleeping. The
gold standard test designed for the assessment of OSA is polysomnography, as approved by the
American Academy of Sleep Medicine and CPAP has been found to be universally beneficial in
treating OSA related complications. Physiologically, the ACC/AHA guidelines recommend pacing
only in patients with prolonged asymptomatic pauses occurring during wakefulness. This case report
proved the above mentioned claim of CPAP treatment.
Social Media in Heart Failure: A Mixed-Methods Systematic Review
Authors: Eliya Yousif , Pellegrini Danielle , Gevaert Andreas B. , Code Jillianne , Van Spall Harriette G.C. 
Published: December 2019

Background:
Among social media (SoMe) platforms, Twitter and YouTube have gained
popularity, facilitating communication between cardiovascular professionals and patients.

Objective:
This mixed method systematic review aimed to assess the source profile and content of
Twitter and YouTube posts about heart failure (HF).

Methods:
We searched PubMed, Embase and Medline using the terms “cardiology,” “social media,”
and “heart failure.” We included full-text manuscripts published between January 1, 1999 and
April 14, 2019. We searched Twitter and YouTube for posts using the hashtags “#heartfailure”,
“#HF”, “#CHF” on May 15, 2019 and July 6, 2019. We performed a descriptive analysis of the
data.

Results::
Three publications met inclusion criteria, providing 677 tweets for source profile analysis;
institutions (54.8%), health professionals (26.6%), and patients (19.4%) were the most common
source profiles. The publications provided 1194 tweets for content analysis: 83.3% were on the
education of professionals; 33.7% on patient empowerment; and 22.3% on research promotion. Our
search on Twitter and YouTube generated 2,252 tweets and >400 videos, of which we analyzed
260 tweets and 260 videos. Sources included institutions (53.5% Twitter, 64.2% YouTube), health
professionals (42.3%, 28.5%), and patients (4.2%, 7.3%). Content included education of professionals
(39.2% Twitter, 62.3% YouTube), patient empowerment (20.4%, 21.9%), research promotion
(28.8%, 13.1%), advocacy of professionals (5.8%, 2.7%), and research collaboration (5.8%,
0%).

Conclusions:
Twitter and YouTube are platforms for knowledge translation in HF, with contributions
from institutions, health professionals, and less commonly, patients. Both focus largely on
education of professionals and less commonly, on patient empowerment. Twitter includes more research
promotion, research collaboration, and professional advocacy than YouTube.
An Automatic Classification of the Early Osteonecrosis of Femoral Head with Deep Learning
Authors: Zhu Liyang , Han Jungang , Guo Renwen , Wu Dong , Wei Qiang , Chai Wei , Tang Shaojie 
Published: December 2019

Background:
Osteonecrosis of Femoral Head (ONFH) is a common complication in
orthopaedics, wherein femoral structures are usually damaged due to the impairment or interruption
of femoral head blood supply.

Aim:
In this study, an automatic approach for the classification of the early ONFH with deep
learning has been proposed.

Methods:
All femoral CT slices according to their spatial locations with the Convolutional Neural
Network (CNN) are first classified. Therefore, all CT slices are divided into upper, middle or lower
segments of femur head. Then the femur head areas can be segmented with the Conditional
Generative Adversarial Network (CGAN) for each part. The Convolutional Autoencoder is employed
to reduce dimensions and extract features of femur head, and finally K-means clustering is
used for an unsupervised classification of the early ONFH.

Results:
To invalidate the effectiveness of the proposed approach, the experiments on the dataset
with 120 patients are carried out. The experimental results show that the segmentation accuracy is
higher than 95%. The Convolutional Autoencoder can reduce the dimension of data, the Peak Signal-
to-Noise Ratios (PSNRs) are better than 34dB for inputs and outputs. Meanwhile, there is a
great intra-category similarity, and a significant inter-category difference.

Conclusion:
The research on the classification of the early ONFH has a valuable clinical merit,
and hopefully it can assist physicians to apply more individualized treatment for patient.
Total Ankle Replacement in Hemophilia
Authors: Rodriguez-Merchan Emerito C. 
Published: December 2019

Introduction:
Severe ankle hemophilic arthropathy can be a calamitous sign of severe
hemophilia with important inferences for activities of daily living.

Aims:
To summarize the contemporary, accessible information on Total Ankle Replacement (TAR)
for ankle hemophilic arthropathy.

Methods:
A search of Cochrane Library and PubMed (MEDLINE) regarding the role of TAR in
ankle hemophilic arthropathy.

Results:
The insufficient information regarding the results of TAR for hemophilic arthropathy is
confined to scanty case series and case reports. An evaluation of the accessible literature reveals
encouraging but inconstant outcomes. The reported rate of adverse events is 33%. The reported
anticipated survival of TAR is 94% at 5 years, 85% at 10 years and 70% at 15 years.

Conclusion:
Whereas people with advanced hemophilic arthropathy of the ankle are prone to ameliorate
pain and range of motion following TAR, there is deficient knowledge to regularly recommend
its use. Adverse events and infection percentages are disturbing. Moreover, the lack of survival
analysis knowledge makes it difficult to assess the benefit to people with hemophilia. TAR is a
demanding surgical procedure and its survival is not comparable to that after hip or knee replacement.
Introducción a la microscopía y nanoscopía a frecuencias GHz y THz
Authors: Qureshi Naser , Ordóñez Romero Cesar Leonardo , Velázquez Benítez Amado , Kolokoltsev Oleg 
Published: December 2019

Se da cuenta del estado actual de la microscopía con microondas y ondas milimétricas, sus ventajas y sus retos. Aunque la microscopía óptica tradicional y sus variantes recientes, que incluyen métodos de super-resolución, es por mucho la microscopía más versátil y usado en las ciencias, existen aplicaciones puntuales en las que la microscopía en rangos del espectro electromagnético con mayor longitud de onda puede proporcionar información física no accesible con la óptica. En este artículo damos a conocer algunos ejemplos recientes, en particular aquellos desarrollados en México.