bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bony Stress and Its Association With Intervertebral Disc Degeneration in the Lumbar Spine: a Review of Clinical and Basic Science Studies
Authors: Chepurin Daniel , Chamoli Uphar , Diwan Ashish D. 
Published: August 2020

Abstract
BackgroundMultiple components of the lumbar spine interact during the normal and pathological function. Bony stress in the lumbar spine is recognised as a factor in the development of pars defects and stress fractures, but its relationship with intervertebral disc (IVD) degeneration is not well understood. Therefore, a translational review encompassing basic science and clinical evidence was conducted to examine the relationship between bony stress in the lumbar spine and IVD degeneration.MethodsOnline databases Scopus, PubMed and MEDLINE via OVID were searched for relevant studies published between January 1980 – February 2020, using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines. Two authors independently analysed the data, noting study characteristics and bias.ResultsThirty-two articles were included in the review: eight human studies, nine finite element analysis studies, three in-vivo biomechanical testing studies, and twelve in-vitro biomechanical testing studies. Of the 32 articles, 19 supported, four rejected and nine made no conclusion on the hypothesis that there is a positive associative relationship between IVD degeneration and bony stress. However, not enough evidence was available to confirm or reject a causal relationship.ConclusionMost studies suggest that the prevalence of IVD degeneration increases with the presence of bony stress, but whether a causal relationship exists is unclear. The literature recommends early diagnosis and clinical suspicion of IVD degeneration and bony stress. Longitudinal studies are required to explore causal relationships between IVD degeneration bony stress.
Pattern of Inpatients Acute Poisonings in Birjand City, East of Iran
Authors: Naseri Kobra , Kiani Zahra , Sajadi Zakieh Sadat , Mehrpour Omid , Sadeghi Mahmood 
Published: August 2020

Abstract
Background: Information on the pattern of acute poisonings in Birjand hospitals is limited. This study aimed to address this knowledge gap by examining the admissions in a poisoning center in Birjand. Methods: Medical records of a main poisoning center in Birjand were reviewed for poisoned patients admitted to hospital from September 2017 to August 2018.Results: During the study period 897 cases of acute poisoning were evaluated. Patients’ age ranged from 11 to 97 years, with a high rate of poisonings between 15 and 25 years. A slight female predominance in poisoning cases was observed. Most cases of poisonings occurred in spring, and the common route of exposure was oral (90.7%). High incidence of poisoning occurred in married couples, uneducated patients, and residents of urban areas. Patients with a previous medical history experienced addiction and psychiatric disorders. Intentional poisoning accounted for 49.5% of acute poisoning cases referred to the hospital in the current study. The main groups of toxicants were pharmaceutical products (45.8%), chemicals (13.3%), and narcotics (9.4%). The mean of hospital stay was 2.8±3.0 days, and the final treatment outcome was 66.0% complete recovery. The mortality rate was 0.8%, and most cases of death were due to pesticides poisoning.Conclusions: Acute poisoning, particularly intentional poisoning, is common in Iran. Due to the high rate of deliberate poisonings, especially in young adults and students, monitoring drugs and distribution and exceptional attention to mental health should be seriously taken into consideration by national health authorities for the prevention of suicide attempts.
Clusters of Responders and Predictive Factors for Response to Supplementation With Boswellia, Turmeric, and Red Algae Extracts in Painful Knee Osteoarthritis: A Prospective Observational Study Using an Arsenal of Patient Centred-measures
Authors: Ait-Abdellah Samira , Gal Caroline , Leblanc Anne , Trouvin Anne-Priscille , Perrot Serge 
Published: August 2020

Abstract
Background: Knee osteoarthritis (KOA) is a common, painful condition. This open-label, observational, longitudinal study evaluated the use of a fixed combination of boswellia, turmeric, and red algae extracts in patients with painful KOA. Given the growing interest in patient-centred care in osteoarthritis, effects were assessed by an arsenal of patient-reported outcome measures (PROMs): Patient Acceptable Symptom Scale (PASS), Minimal Clinically Important Improvement (MCII), Patient Global Impression of Change (PGIC), and Lequesne algofunctional index (LAFI). Patients also completed a list of 17 items on pain quality.Methods: Patients with painful unilateral or bilateral KOA were included. They had to take 1-4 capsules per day of a dietary supplement containing boswellia, turmeric, and red algae extracts (Cartimotil Fort®, PiLeJe Laboratoire, Paris, France) for 90 days. Patients completed PROMs on Days 0 (baseline), 10, 20, 30, 60, and/or 90. Results: From March 2017 to March 2019, 118 patients [female: 69.5%; age: 62.9 (9.5) years, mean (SD); BMI: 26.4 (4.0) kg/m²; DN4 <4: 90.7%] were included in the study and took at least one capsule. Mean (SD) follow-up duration was 100.7 (54.9) days. Pain relief was maximal on Day 90: 64.5% of patients were responders (positive PASS); 68.8% and 58.4% had MCII and PGIC scores indicating positive effect (score ≥3) or global improvement (score ≥5); 73.3% (versus 47.5% at baseline) were mildly/moderately disabled (LAFI score <8); 55.2% had meaningful decrease (-30%) in pain intensity (VAS), 35.1% (versus 59.2% at baseline) took analgesics as supplementary treatment. Median time to first PASS change was 34 days. Pain intensity (VAS) as well as two pain characteristics (i.e., “Stabbing pain” and “Widespread pain”) were independent factors associated with non-response on Day 30. Four clusters of responders were isolated according to pain characteristics, with one cluster exhibiting a higher responder rate. Treatment compliance and safety were satisfactory.Conclusions: This study showed that the fixed combination of boswellia, turmeric, and red algae extracts improved KOA patients. Further studies are needed to confirm the observations. Beyond these results, this study showed the importance of PROs and specific pain qualitative descriptors for accurate evaluation of dietary supplement approaches in painful conditions. Trial registration details: ClinicalTrials.gov, NCT02977936. Registered 30 November 2016, https://clinicaltrials.gov/ct2/show/NCT02977936
Association of STAT3 Gene polymorphism with noise-induced hearing loss(NIHL) in the Chinese population
Authors: Gao Dengfeng , Wang Boshen , Sun Dawei , Wang Ning , Guo Jiadi , Zhang Suhao , Zhu Baoli 
Published: August 2020

Abstract
Objectives: NIHL is a disease with irreversible damage caused by multi-factor interaction, and the STAT3 is an essential protein with signal transduction and transcription functions. This study is aimed to explore the effect of STAT3 polymorphism on individual susceptibility to NIHL individuals, and to further examine the interaction between lifestyles and NIHL in the dominant model .Methods: This study was designed a case-control study and included 609 NIHL cases and 611 healthy hearing controls from the Jiangsu province of China. By collecting the lifestyle and demographic information of the study participants, genotyping the collected blood samples, and performing Real-time Quantitative PCR (qRT-PCR) to analyze and investigate the potential association between STAT3 SNPs and NIHL.Results: Statistical analysis results show that individuals carrying the C allele of rs1053023 and rs1053005 were more likely to develop NIHL than individuals carrying the T allele (OR = 1.367, 95% CI = 1.148-1.628, P = 0.0001 and OR = 1.37, 95% CI = 1.147-1.636, P = 0.001). In the dominant model (TC/CC genotype and TT genotype), stratified analysis of lifestyle, we found that people who smoke regularly are more likely to suffer from NIHL than non-smokers or occasional smokers. Besides, the expression of STAT3 was higher in NIHL cases by real-time quantitative PCR.Conclusion: Gene polymorphisms, rs1053023 and rs1053005, from STAT3, are associated with NIHL and C alleles of rs1053023 and rs1053005 within STAT3 may become biomarkers for workers exposed to noise.
Effect of Corneal Refractive Surgery on Accommodative and Binocular Dysfunctions Among Civilian Pilots in Southwest China
Authors: Wu Ye , Zhang Zhen , Liao Meng , Li Qi , Tang XueLin , Liu Longqian 
Published: August 2020

Abstract
Background: To analyze whether corneal refractive surgery (CRS) is associated with the distribution of different accommodative dysfunctions (ADs) and binocular dysfunctions (BDs) in civilian pilots. A further aim was to analyze the percentages and visual symptoms associated with ADs and/or BDs in this population.Methods: One hundred and eight civilian pilots who underwent CRS from January 2001 to July 2012 (age range: 23-35 years) and 99 emmetropic civilian pilots (age range: 23-35 years) were included in this study. Visual symptoms, refractive status, accommodative and binocular tests of each subject were performed.Results: No significant difference was observed between the CRS and emmetropic groups in the overall prevalence of ADs and BDs (15.7% and 15.2% in the CRS and emmetropic groups, respectively; P=0.185). ADs were present in 4.63% and 3.03% of the CRS and emmetropic group, respectively. BDs were observed in 11.1% and 12.1% of the CRS and emmetropic group, respectively, yielding no significant differences between the groups in the prevalence of ADs or BDs (AD: P=0.094; BD: P=0.105). Pilots with ADs and/or BDs had significantly more visual symptoms than pilots with normal binocular vision (p < 0.001). Conclusions: CRS for civilian pilots with low-moderate myopia might not impact binocular functions. ADs and/or BDs commonly occur in both emmetropia pilots and pilots who undergo CRS, and pilots with ADs and/or BDs are associated with increased symptoms. This study confirms the importance of a full assessment of binocular visual functions in detecting and remedying these dysfunctions in this specific population.Trial registration number: ChiCTR1900027235 (date: 6 Nov 2019) Available at www.medresman.org
Visualization of the Meridian Courses by the Mineral Pulse Light Stimuli
Authors: cha yongchol , choe hyok , oh songjin , cha zinhwa , dong zhang 
Published: August 2020

Abstract
Background; The infrared thermographic technology was used to visualize the meridian course, "energetic paths" at the human body surface from 1980s. However, the study failed as acupuncture, moxa and Laser needle stimulus. Objectives; The purpose of this study is to visualize the meridian course by mineral pulse light stimulator, new acupoints stimulus method. Methods; Any acupoints at arms (PC6) and legs (SP6, SP4, KI3) were stimulated by the mineral pulse light stimulator during 15 ~ 30 minutes. Results; When any acupoints at arms and legs were stimulated by the mineral pulse light stimulator, the meridian-like high thermal lines were induced along the connective classic meridians after 3 minutes usually. The rising temperature is average 1.85 ± 0.52℃ (P < 0.001). Inducing rate of MLHTL is 80.3% (male 80.0%, female 3.0%) and reappearance rate 100%. Conclusions; The meridian-like high thermal lines are induced along the meridian course at the classic meridian figure, so that the meridians course as "energetic paths", were visualized by mineral pulse light stimulator, new acupoints stimulus method first on the world. Everyone can induce MLHTL by MPL stimulator (Version 1.0), so that can see it anytime from now on.
Ultra-fast self-gelling powder mediate robust wet adhesion to promote healing of gastrointestinal perforations
Authors: Peng Xin , Xia Xianfeng , Xu Xiayi , Yang Xuefeng , Yang Boguang , Zhao Pengchao , Yuan Weihao , Chiu Philip , Bian Liming 
Published: August 2020

Abstract
Achieving strong adhesion of bioadhesives on wet tissues remains a challenge and an acute clinical need due to the interfering interfacial water and lack of adhesive–tissue interactions. Herein we report a self-gelling and adhesive polyethyleneimine and polyacrylic acid (PEI/PAA) powder, which can absorb interfacial water to rapidly form a physically crosslinked hydrogel in situ within two seconds due to strong physical interactions between the polymers. Furthermore, the physically crosslinked polymers can diffuse into the substrate polymeric network to enhance wet adhesion on various tissues. Superficial deposition of PEI/PAA powder can effectively seal damaged porcine stomach and intestine despite excessive mechanical challenges. We further demonstrate the use of PEI/PAA powder as sealants to enhance the treatment outcomes of gastric perforation in a rat model. Owing to their strong wet adhesion, excellent cytocompatibility, adaptability to fit complex target sites, and easy synthesis, we believe that the PEI/PAA powder are promising bioadhesives with a wide array of biomedical applications.
Comparisons of Simulation Results between Passive and Active FSI Models for Left Ventricle in Hypertrophic Obstructive Cardiomyopathy
Authors: Huang Xueying , Deng Long , Zuo Heng , Yang Chun , Song Yunhu , Lesperance Mary , Tang Dalin 
Published: August 2020

Abstract
Background. Patient-specific active Fluid-Structure Interactions (FSI) model is a useful approach to non-invasively investigate the hemodynamics in the heart. However, it takes a lot of effort to obtain the proper external force boundary conditions for active models, which heavily restrained the time-sensitive clinical applications for active computational models. Methods. The simulation results of 12 passive FSI models based on 6 patients’ pre-operative and post-operative CT images were compared with corresponding active models to investigate the differences in hemodynamics and cardiac mechanics between these models. Results. It was found that there was no significant difference in shear stress and pressure difference on mitral valve leaflet (MVL) between passive and active models, but a significant difference was found in wall stress on the inner boundary of left ventricle (Endocardium). It was also found that flow shear stress and pressure difference on the MVL were significantly decreased after successful surgery in both active and passive models. Conclusion. Our results suggested that the passive models may provide good approximated hemodynamic results at 5% RR interval, which is crucial for analyzing the initiation of systolic anterior motion (SAM). Comparing to active models, the passive models decrease the complexity of the modeling construction and the difficulty of convergence significantly. Therefore, with proper boundary conditions and sufficient clinical data, the passive computational model may be a good substitution model for the active model to perform hemodynamic analysis for left ventricle to investigate the mechanisms of the initiation of SAM.
Nuclear Respiratory Factor 1 Associated with Prognosis and Immune Infiltration in Hepatocellular Carcinoma
Authors: Wang Dan , Huang Linlin , Zhang Xiaojing , Sun Pingping , Lu Yapeng , Zhu Li 
Published: August 2020

Abstract
Background: Recent studies have shown that functional mitochondria are essential for cancer cells. Nuclear respiratory factor 1 (NRF1) is a transcription factor that activates mitochondrial biogenesis and the expression of the respiratory chain, but little is known about its prognostic value and tumor-infiltrating lymphocytes association. Here, we evaluated the association among expression of NRF1, clinicopathological characteristics, survival and immune infiltration in hepatocellular carcinoma (HCC).Methods: We used the Tumor Immune Estimation Resource (TIMER) to analyze the difference of NRF1 mRNA expression in human cancers. Clinical-pathological information and follow-up data were collected from HCC (n = 171) and chronic hepatitis (n = 113) patients. NRF1 expression were scored based on the percentage and intensity of immunohistochemical staining in pathological slides. Correlations between clinical features and the expression of NRF1 were evaluated by Chi-square test, Kaplan-Meier curves, logrank tests and multivariate Cox regression analysis. The correlations between NRF1 expression and gene marker sets of tumor infiltrating lymphocytes (TILs) were analyzed by TIMER and Gene Expression Profiling Interactive Analysis (GEPIA) databases. Results: NRF1 mRNA expression was significantly higher in HCC than in normal tissue. Compared with chronic hepatitis, more frequency of NRF1 high expression are found in HCC (31.58 % vs 13.27 %, P < 0.001, P < 0.001). In addition, the NRF1 expression was significantly associated with hepatic cirrhosis (P = 0.021) and vascular invasion (P = 0.025). NRF1 expression was also a significant independent predictor of survival in HCC (P = 0.003; HRadj = 0.20; 95% CI = 0.09 – 0.44). NRF1 showed positively correlated with TILs, including B cell (r = 0.384, P = 1.68e-13), CD8+ T cells (r = 0.246, P = 3.99e-06), CD4+ T cells (r = 0.535, P = 6.90e-27), macrophage (r = 0.506, P = 1.52e-23), neutrophils (r = 0.465, P = 6.08e-20) and dendritic cell (r = 0.404, P = 8.61e-15). The marker genes of TILs correlated significantly with NRF1 expression.Conclusions: NRF1 expression was a useful independent prognostic factor and correlated with tumor immune infiltration in HCC.
A Novel Prognostic Nomogram for 2-Year Survival in HER2-Positive Breast Cancer Patients
Authors: Chen Mengdi , Wu Jiayi , Liu Deyue , Chen Weilin , Lin Caijin , Andriani Lisa , Ding Shuning , Shen Kunwei , Zhu Li 
Published: August 2020

Abstract
Background: Targeted therapies have largely improved prognosis of human epidermal growth factor receptor 2 (HER2)-positive breast cancer. Yet, disease can still progress rapidly for some patients in the first two years after diagnosis. Our study aimed to establish a nomogram model to predict 2-year breast cancer-specific survival (BCSS) in early HER2-positive breast cancer patients. Methods: A total of 32,481 HER2-positive patients derived from Surveillance, Epidemiology, and End Results (SEER) database were included in the construction of nomogram. Concordance index (C-index) and calibration curve were used to evaluate the discrimination ability and predictive accuracy. We also tested the model in 804 patients from Shanghai Jiao Tong University Breast Cancer Data Base (SJTU-BCDB). Results: Age, estrogen receptor (ER) status, progesterone receptor (PR) status, histologic type, T stage and N stage were selected to construct the nomogram according to multivariable analysis. The 2-year BCSS rate was 95% and 60% for patients at low risk (<8 points) and high risk (>13 scores) respectively. The C-index of model derived from SEER database is 0.81 (95%CI 0.79-0.83). Sensitivity analysis was performed in patients undergoing breast surgeries with the C-index of 0.81 (95%CI 0.79-0.83). Validation in 804 patients from SJTU-BCDB showed respective C-index of 0.77 (95%CI, 0.62-0.92) in total population, 0.67 (95%CI 0.44-0.90) in patients receiving anti-HER2 therapy and 0.90 (95%CI 0.81-0.90) in those without targeted therapy. Conclusions: The novel nomogram can predict 2-year survival outcome in HER2-positive patients independent of receiving anti-HER2 therapy or not and help clinicians to adjust therapeutic strategies for those patients with higher risk.
Treatment of Patient With Angina Pectoris by the Mineral Pulse Light Stimulus on PC6 Acupoints - A Case Report
Authors: cha yongchol , choe hyok , oh songjin , cha zinhwa 
Published: August 2020

Abstract
Background; Angina pectoris is a clinical syndrome of precordial discomfort or pressure due to transient myocardial ischemia without infarction. Treatment may include antiplatelet drugs, nitrates, beta-blockers, calcium channel blockers, ACE inhibitors, statins, and coronary angioplasty or coronary artery bypass graft surgery.Objectives; The purpose of this study is to perform clinical trial on an angina pectoris patient by mineral pulse light stimulus on PC6 acupoints without any drugs use.Methods; Angina pectoris patient was stimulated by mineral pulse light stimulator (MPLS). Stimulus acupoints; PC6. The selected acupoints were stimulated by MPLS for 50~60 minutes once a day. The same method was performed on the patient for 15days without any drugs use (nitroglycerin, isosorbide, atenolol, diltiazem, etc.).Results; A heart attack after treatment decreased gradually, a heart attack disappeared after 3 days, and the recurrence was no for 3 years until now.Conclusions; Angina pectoris patient was recovered to normal by mineral pulse light stimulus on PC6 acupoints without any drugs use.
MiR-378 Has the Capacity to Serve as a Diagnostic Biomarker for Prostate Cancer Patient
Authors: Cao Shuangqing , Zheng Lei 
Published: August 2020

Abstract
Background: This study aimed to examine the expression of serum miR-378 in prostate cancer (PCa) patients and healthy individuals and to identify the value of miR-378 in PCa diagnosis.Methods: The expression of serum miR-378 between groups was compared by t-test. The association between miR-378 expression and clinical characteristics of PCa patients was assessed using Chi-square test. The diagnostic value of serum miR-378 in PCa was estimated by the receiver operating characteristic (ROC) analysis.Results: The expression level of serum miR-378 in PCa patients was significantly lower than that in healthy individuals (P<0.0001). MiR-378 expression was affected by positive AR (P=0.004), large Gleason score (P=0.013) and advanced TNM stage (P=0.020), however, it had no relationship with age, serum PSA, NED rate and urine retention (all, P>0.05). The ROC curve showed that the optimal cutoff value was 1.845, giving the sensitivity and specificity of 75.21% and 89.77%, respectively. Besides, the area under the ROC curve (AUC) was 0.894, indicating serum miR-378 was of great diagnostic value in screening PCa patients from healthy controls (P<0.0001, 95%CI =0.852-0.936).Conclusions: Taken together, the increased expression of serum miR-378 might act as a potential biomarker for PCa diagnosis.
25-gauge vitrectomy with gas tamponade for rhegmatogenous retinal detachment: experienced vs. inexperienced surgeons
Authors: Pencak Martin , Veith Miroslav , Stranak Zbynek , Dite Jakub , Vranova Jana , Studeny Pavel 
Published: August 2020

Abstract
Background: To compare the results and complication rates of a 25-gauge pars plana vitrectomy (25 g PPV) with gas tamponade for rhegmatogenous retinal detachment (RRD) between experienced and inexperienced surgeons.Methods: This is a retrospective comparative consecutive case series study of patients with uncomplicated RRD treated with 25 g PPV with gas tamponade. Patients were divided into 2 groups: In Group 1 (ESG) the procedure was performed by an experienced vitreoretinal surgeon and in Group 2 (ISG) the procedure was performed by 2 inexperienced surgeons. Anatomical and functional results and complication rates were compared between the two groups.Results: 216 eyes were included in the study. In the ESG (106 eyes), the single operation success rate was 94.3%, and the final success rate was 100%. The mean best-corrected visual acuity (BCVA) improved from 0.38 decimal to 0.73 decimal. In the ISG (110 eyes), the single operation success rate was 93.6%, and the final success rate was 100.0%. The mean BCVA improved from 0.33 decimal to 0.74 decimal. The differences between groups were not statistically significant. There was no difference in complication rates between groups.Conclusions: A 25 g PPV with gas tamponade for uncomplicated RRD renders excellent functional and anatomical results even when performed by an inexperienced surgeon. The complication rate was comparable between experienced and inexperienced surgeons.