bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of two nanometer magnetic flocculants and treatment of slime wastewater
Authors: Wang Bing , Xu Weijun , Fu Jia , Wang Wei , Xiao Xueting 
Published: November 2019

Abstract
Nano Fe3O4 was prepared by co-precipitation method and loaded into cellulose and biochar to prepare Fe3O4-chitosan-cellulose and Fe3O4-chitosan-biochar.XRD, ft-ir, SEM and energy spectrum showed that the target product was obtained. Fe3O4-chitosan-cellulose and Fe3O4-chitosan-biochar flocculant used in coal slime water treatment respectively. The results showed that water turbidity and COD removal rate of Fe3O4-chitosan-cellulose were 96.90% and 78.34% respectively and the water turbidity and COD removal rates of Fe3O4-chitosan-biochar on slurry water were 94.05% and 73.89% respectively. Fe3O4-chitosan-biochar treatment is better.
Monte Carlo calculated kilovoltage x-ray arc therapy plans for three lung cancer patients
Authors: Breitkreutz Dylan Yamabe , Renaud Marc-Andre , Weil Michael David , Zavgorodni Sergei , Han Jaeyoung , Baxter Henry , Seuntjens Jan , Song Samuel , Boyd Douglas , Bazalova-Carter Magdalena 
Published: November 2019

Abstract

Purpose: The intent of this work was to evaluate the ability of our 200 kV kilovoltage arc therapy (KVAT) system to treat realistic lung tumors without exceeding dose constraints to organs-at-risk (OAR). Methods and Materials: Monte Carlo (MC) methods and the McO optimization framework generated and inversely optimized KVAT treatment plans for 3 SABR lung cancer patients. The KVAT system was designed to treat deep-seated lesions with kilovoltage photons. KVAT delivers dose to roughly spherical PTVs and therefore non-spherical PTVs were divided into spherical sub-volumes. A prescription dose of 12 Gy/fx × 4 fractions was planned to 90% of the PTV volume. KVAT plans were compared to VMC++ calculated, 6 MV stereotactic ablative radiotherapy (SABR) treatment plans. Dose distributions, dose volume histograms, gradient index (GI), planned mean doses and plan treatment times were calculated. Dose constraints for organs-at-risk (OAR) were taken from RTOG 101. Results: All plans, with the exception of the rib dose calculated in one of the KVAT plans for a peripheral lesion, were within dose-constraints. In general, KVAT plans had higher planned doses to OARs. KVAT GI values were 5.7, 7.2 and 8.9 and SABR values were 4.6, 4.1, and 4.7 for patient 1, 2 and 3, respectively. KVAT plan treatment times were 49, 65 and 17 min for patients 1, 2 and 3, respectively. Conclusions: Inverse optimization and MC methods demonstrated the ability of KVAT to produce treatment plans without exceeding TG 101 dose constraints to OARs for 2 out of 3 investigated lung cancer patients.
Multi-kernel linear mixed model with adaptive lasso for prediction analysis on high-dimensional multi-omics data
Authors: Li Jun , Lu Qing , Wen Yalu 
Published: November 2019

Abstract

Motivation
The use of human genome discoveries and other established factors to build an accurate risk prediction model is an essential step toward precision medicine. While multi-layer high-dimensional omics data provide unprecedented data resources for prediction studies, their corresponding analytical methods are much less developed.

Results
We present a multi-kernel penalized linear mixed model with adaptive lasso (MKpLMM), a predictive modeling framework that extends the standard linear mixed models widely used in genomic risk prediction, for multi-omics data analysis. MKpLMM can capture not only the predictive effects from each layer of omics data but also their interactions via using multiple kernel functions. It adopts a data-driven approach to select predictive regions as well as predictive layers of omics data, and achieves robust selection performance. Through extensive simulation studies, the analyses of PET-imaging outcomes from the Alzheimer’s Disease Neuroimaging Initiative study, and the analyses of 64 drug responses, we demonstrate that MKpLMM consistently outperforms competing methods in phenotype prediction.

Availability and implementation
The R-package is available at https://github.com/YaluWen/OmicPred.

Supplementary information
Supplementary data are available at Bioinformatics online.
Impact of a Multiplexed Polymerase Chain Reaction Panel on Identifying Diarrheal Pathogens in Hematopoietic Cell Transplant Recipients
Authors: Rogers Wesley S , Westblade Lars F , Soave Rosemary , Jenkins Stephen G , van Besien Koen , Singh Harjot K , Walsh Thomas J , Small Catherine B , Shore Tsiporah , Crawford Carl V , Satlin Michael J 
Published: November 2019

AbstractBackgroundDiarrhea is common and associated with substantial morbidity among hematopoietic cell transplant (HCT) recipients, but the etiology is often not identified. Multiplexed polymerase chain reaction (PCR) assays increase the detection of diarrheal pathogens, but the impact of this technology in this population has not been evaluated.MethodsOur center replaced stool cultures and other conventional microbiologic methods with the FilmArray Gastrointestinal Panel (GI PCR) in June 2016. We reviewed all adult patients who received an HCT from June 2014–May 2015 (pre–GI PCR, n = 163) and from June 2016–May 2017 (post–GI PCR, n = 182) and followed them for 1 year after transplantation. Clostridioides difficile infection was diagnosed by an independent PCR test in both cohorts.ResultsThe proportion of patients with ≥1 identified infectious diarrheal pathogen increased from 25% to 37% after implementation of GI PCR (P = .01). Eight patients (5%) in the pre–GI PCR cohort tested positive for a pathogen other than C. difficile versus 49 patients (27%) in the post–GI PCR cohort (P &lt; .001). The most common non–C. difficile diarrheal pathogens in the post–GI PCR cohort were enteropathogenic Escherichia coli (n = 14, 8%), norovirus (n = 14, 8%), and Yersinia enterocolitica (n = 7, 4%). The percentage of diarrheal episodes with an identified infectious etiology increased from 14% to 23% (P = .001). Median total costs of stool testing per patient did not increase (pre: $473; post: $425; P = .25).ConclusionsInfectious etiologies of diarrhea were identified in a higher proportion of HCT recipients after replacing conventional stool testing with a multiplexed PCR assay, without an increase in testing costs.
Rationale, experimental data, and emerging clinical evidence on early and preventive use of levosimendan in patients with ventricular dysfunction
Authors: Cosentino Nicola , Niccoli Giampaolo , Fracassi Francesco , Rebuzzi Antonio , Agostoni Piergiuseppe , Marenzi Giancarlo 
Published: November 2019

Abstract
Acute ventricular dysfunction (AVD) is a complex condition with substantial morbidity and mortality, still featuring unique therapeutic challenges. Levosimendan is a calcium sensitizer and ATP-dependent potassium channel opener that was developed as an inodilating drug for the treatment of acute heart failure and cardiogenic shock. Differently from other more widely used inotropic agents, levosimendan has some exclusive characteristics, in terms of mechanisms of action, pharmacodynamic profile, and haemodynamic effects. This may have important clinical implications. In particular, in patients with AVD or in patients with pre-existing severe ventricular impairment undergoing planned myocardial stress, the administration of levosimendan before the onset of overt symptoms or before cardiovascular therapeutic procedures may have the potential to bridge the patient through the critical phase. In this review, we will focus on the rationale, the existing experimental data, and the emerging clinical experience supporting an early, even preventive use of levosimendan in severe ventricular dysfunction, beyond its recognized indications.
Limited DNA repair gene repertoire in Ascomycete yeast revealed by comparative genomics
Authors: Milo Shira , Misgav Reut Harari , Hazkani-Covo Einat , Covo Shay 
Published: November 2019

Abstract
Ascomycota is the largest phylogenetic group of fungi that includes species important to human health and wellbeing. DNA repair is important for fungal survival and genome evolution. Here, we describe a detailed comparative genomic analysis of DNA repair genes in Ascomycota. We determined the DNA repair gene repertoire in Taphrinomycotina, Saccharomycotina, Leotiomycetes, Sordariomycetes, Dothideomycetes, and Eurotiomycetes. The subphyla of yeasts, Saccharomycotina and Taphrinomycotina, have a smaller DNA repair gene repertoire comparing to Pezizomycotina. Some genes were absent from most, if not all, yeast species. To study the conservation of these genes in Pezizomycotina, we used the GLOOME algorithm that provides the expectations of gain or loss of genes given the tree topology. Genes that were absent from most of the species of Taphrinomycotina or Saccharomycotina showed lower conservation in Pezizomycotina. This suggests that the absence of some DNA repair in yeasts is not random; genes with a tendency to be lost in other classes are missing. We ranked the conservation of DNA repair genes in Ascomycota. We found that Rad51 and its paralogs were less conserved than other recombinational proteins, suggesting that there is a redundancy between Rad51 and its paralogs, at least in some species. Finally, based on the repertoire of UV repair genes, we found conditions that differentially kill the wine pathogen Brettanomyces bruxellensis and not Saccharomyces cerevisiae. In summary, our analysis provides testable hypotheses to the role of DNA repair proteins in the genome evolution of Ascomycota.
Using Patient- and Family-Reported Outcome and Experience Measures Across Transitions of Care for Frail Older Adults Living at Home: A Meta-Narrative Synthesis
Authors: Schick-Makaroff Kara , Karimi-Dehkordi Mehri , Cuthbertson Lena , Dixon Duncan , Cohen S Robin , Hilliard Neil , Sawatzky Richard 
Published: November 2019

Abstract

Background and Objectives
Our aim was to create a “storyline” that provides empirical explanation of stakeholders’ perspectives underlying the use of patient- and family-reported outcome and experience measures to inform continuity across transitions in care for frail older adults and their family caregivers living at home.

Research Design and Methods
We conducted a meta-narrative synthesis to explore stakeholder perspectives pertaining to use of patient-reported outcome and experience measures (PROMs and PREMs) across micro (patients, family caregivers, and healthcare providers), meso (organizational managers/executives/programs), and macro (decision-/policy-makers) levels in healthcare. Systematic searches identified 9,942 citations of which 40 were included based on full-text screening.

Results
PROMs and PREMS (54 PROMs; 4 PREMs; 1 with PROM and PREM elements; 6 unspecified PROMs) were rarely used to inform continuity across transitions of care and were typically used independently, rarely together (n = 3). Two overarching traditions motivated stakeholders’ use. The first significant motivation by diverse stakeholders to use PROMs and PREMs was the desire to restore/support independence and care at home, predominantly at a micro-level. The second motivation to using PROMs and PREMs was to evaluate health services, including cost-effectiveness of programs and hospital discharge (planning); this focus was rarely at a macro-level and more often split between micro- and meso-levels of healthcare.

Discussion and Implications
The motivations underlying stakeholders’ use of these tools were distinct, yet synergistic between the goals of person/family-centered care and healthcare system-level goals aimed at efficient use of health services. There is a missed opportunity here for PROMs and PREMs to be used together to inform continuity across transitions of care.
The Importance of User Involvement: A Systematic Review of Involving Older Users in Technology Design
Authors: Fischer Björn , Peine Alexander , Östlund Britt 
Published: November 2019

AbstractBackground and ObjectivesThere is a lack of understanding of how older adults’ involvement and participation matters in actual design practice. This systematic literature review investigates existing empirical studies involving older users during the design of technologies and explores the nature and consequences of involving older people.Research Design and MethodsOur literature review is informed by the guidelines of the PRISMA statement. We examined the included studies by means of thematic content analysis to identify the nature of older users’ involvement and existing evidence on what consequences it has.ResultsIn total, 40 empirical studies published in the period 2014–2018 are included in the review. Most empirical studies involve older people from local networks, with underlying stereotypical images and at lower levels of participation. The results reveal three main consequences of involving older users: learning, adjusted design, and an increased sense of participation. Furthermore, we found that user involvement is a structured process whose outcomes are contingent on a range of premises.Discussion and ImplicationsSynthesizing the results, we develop the concept of user involvement and present an analytical framework. Our results have implications for researchers and policy makers, since they throw into question the widely held assumption that involving older people inevitably yields beneficial outcomes.
Examining the processes and effects of an exemplar school-based well-being approach on student competency, autonomy and relatedness
Authors: Vella-Brodrick Dianne A , Chin Tan-Chyuan , Rickard Nikki S 
Published: November 2019

Abstract
As the application of positive education becomes more prevalent in schools, the importance of gathering information on optimal processes and outcomes associated with the programs, increases. The fulfillment of psychological needs such as competence, relatedness and autonomy, have seldomly been explored, yet they seem inextricably linked with well-being. It is also important to examine program qualities relating to delivery, relevance and practice opportunities. The current study examines (i) psychological need satisfaction as an outcome, using a quasi-experimental design and (ii) the processes involved in program delivery, using an explanatory sequential design. Year 9 students participating in the Geelong Grammar School (GGS) Timbertop well-being experience in Australia (n = 119) and 79 best matched well-being as usual (WBAU) students completed a psychological need satisfaction survey. A subgroup of 46 students also participated in focus groups. Mixed design analyses of variance indicated that the Timbertop Positive Education students experienced improved competence, relatedness and autonomy after the school year compared with ‘WBAU’ students. Findings from student focus groups also support the importance of well sequenced, active, focused and explicit learning processes for program success. This study provides support for building psychological need satisfaction with a positive education program that adopts practical, interactive and goal-oriented well-being learnings. This is encouraging and supports a context adapted replication and evaluation of the general Positive Education approach adopted by GGS in other schools.
The economic costs of seal presence in Swedish small-scale fisheries
Authors: Waldo Staffan , Paulrud Anton , Blomquist Johan 
Published: November 2019

Abstract
Growing seal populations are examples of successful marine management, and the seals are often seen as a symbol of a thriving ecosystem. However, seals are well known to interact with local small-scale fisheries by feeding from the gears. This causes both lost catches and broken gear, which negatively affect the economic viability of the small-scale fisheries. While lost catches are known to be substantial, no information is currently available on costs for mending gear, searching for fishing grounds with less seals, etc. This article estimates these costs from a questionnaire sent to Swedish fishers. The total cost due to seals for small-scale fisheries is about €690 000, which corresponds to 7% of the expenditure for purchased goods (not labour and capital). The total time spent on seal-related work corresponds to ∼8% of total working time. Combining additional costs with revenue losses due to decreased catches, it is shown that the economic viability of the small-scale fisheries becomes low due to the seal interaction, which affects the economic and social sustainability of the sector.
Genotoxicity assessment of four novel quinazoline-derived trypanocidal agents in the Drosophila wing somatic mutation and recombination test
Authors: Santos-Cruz Luis Felipe , Ramírez-Cruz Bertha Guadalupe , García-Salomé Miguel , Olvera-Romero Zaira Yuriria , Hernández-Luis Francisco , Hernández-Portilla Luis Barbo , Durán-Díaz Ángel , Dueñas-García Irma Elena , Castañeda-Partida Laura , Piedra-Ibarra Elías , Mendoza-Martínez César , Heres-Pulido María Eugenia 
Published: November 2019

Abstract
Chagas disease, caused by the protozoan Trypanosoma cruzi, has increased in the world due to migration, travelling and climate change; at present, the principal problem is that common trypanocidal agents have resulted in toxic or inconvenient side effects. We tested for genotoxicity in the standard (ST) and high bioactivation (HB) crosses of Drosophila wing somatic mutation and recombination test, four novel trypanocidal agents derived from 2, 4, 6-triaminquinazoline (TAQ): 2,4-diamino-6 nitro-1,3 diazonaftalene (S-1QN2-1), 2,4-diacetamino-6-amino 1,3 diazonaftalene (D-1), N6-(4,methoxybenzyl)quinazoline-2,4,6-triamine (GHPM) and N6-[4-(trifluoromethoxy)benzyl]quinazoline-2,4,6-triamine (GHPMF) at 1.9, 3.9, 7.9 and 15 µM, respectively. Also, high-pressure liquid chromatography (HPLC) analysis was run to determine the remanence of either drug in flare, and Oregon R(R)-flare flies emerged from treated larvae. S-1QN2-1 showed genotoxicity only in the ST cross, increasing the small, large and total spot frequencies at all concentrations and twin spots only at 1.9 µM; D-1 and GHPM showed significant increments of large spots only at 15 µM in the ST cross; GHPMF was not genotoxic at any concentration or either cross. In the mwh clones accumulated distribution frequencies analysis, associated with disrupted cell division, S-1QN2-1 caused alterations in the ST cross at all concentrations but only at 15 µM in the HB cross; D-1 caused alterations at 3.9, 7.9 and 15 µM in the ST cross and at 1.9 and 15 µM in the HB cross; GHPM caused alterations at 7.9 and 15 µM in the ST cross and also at 1.9, 3.9 and 7.9 µM in the HB cross; GHPMF caused those alterations at all concentrations in the ST cross and at 1.9, 3.9 and 7.9 µM in the HB cross. The HPLC results indicated no traces of either agent in the flare and Oregon R(R)-flare flies. We conclude that S-1QN2-1 is clearly genotoxic, D-1 and GHPM have an unclear genotoxicity and GHPMF was not genotoxic; all quinazoline derivatives disrupted cell division. GHPMF is a good candidate to be tested in other genotoxicity and cytotoxic bioassays. The differences in the genotoxic activity of these trypanocidal agents are correlated with differences in their chemical structure.
Invasive Genitourinary Aspergillosis in a Patient with Chronic Lymphocytic Leukemia Treated with Venetoclax: Case Report and Review of the Literature
Authors: Albin Owen R , Soper Nathaniel , Khurana Irina , Kauffman Carol A 
Published: November 2019

Abstract
Novel targeted pharmacotherapies have ushered in a new era in the management of chronic lymphocytic leukemia (CLL). Postmarketing surveillance indicates that some of these agents are associated with unexpected increases in opportunistic infections. In this report, we present a case of primary genitourinary invasive aspergillosis in a patient with CLL treated with venetoclax. We briefly review both genitourinary aspergillosis and infection risks associated with venetoclax treatment for CLL.
Massage therapy for paediatric procedural pain: A rapid review
Authors: Bernstein Kylie , Karkhaneh Mohammad , Zorzela Liliane , Jou Hsing , Vohra Sunita 
Published: November 2019

AbstractBackgroundPain is a common paediatric problem, and procedural pain, in particular, can be difficult to manage. Complementary therapies are often sought for pain management, including massage therapy (MT). We assessed the evidence for use of MT for acute procedural pain management in children.MethodsWe searched five main databases for (i) primary studies in English, (ii) included children 0 to 18 years of age, (iii) compared MT for procedural pain management to standard care alone or placebo, and (iv) measured pain as the primary or secondary outcome. The data were extracted by one author and verified by a second author. Randomized controlled trials were evaluated using the Cochrane Risk of Bias tool.ResultsEleven paediatric trials of procedural pain in neonatal, burn, and oncology populations, a total of 771 participants, were identified. Eight reported statistically significant reductions in pain after MT compared to standard care. Pain was measured using validated pain scales, or physiologic indicators. The studies were heterogeneous in population, techniques, and outcome measures used. No adverse events associated with MT were identified.ConclusionMT may be an effective nonpharmacologic adjunct for management of procedural pain in children.
Deformed K− nuclei in the Skyrme–Hartree–Fock approach
Authors: Jin Yun , Chen Chao Feng , Zhou Xian-Rong , Cheng Yi-Yuan , Schulze H-J 
Published: November 2019

Abstract
The properties of kaonic nuclei are studied using a two-dimensional Skyrme–Hartree–Fock model with a $KN$ Skyrme force. We focus in particular on the instability of the solutions for a too strong $KN$ interaction, which determines a maximum value of the kaon binding in this approach. We then analyze the change of the deformation properties of several core-deformed nuclei caused by the added kaon, and find a shrinking of the core and in some cases a complete loss of deformation.
Retinoic acid accelerates the specification of enteric neural progenitors fromin vitro-derived neural crest
Authors: Frith Thomas J.R , Gogolou Antigoni , Hackland James O.S , Barbaric Ivana , Thapar Nikhil , Burns Alan J. , Andrews Peter W , Tsakiridis Anestis , McCann Conor J. 
Published: November 2019

SummaryThe enteric nervous system (ENS) is derived primarily from the vagal neural crest, a migratory multipotent cell population emerging from the dorsal neural tube between somites 1-7. Defects in the development and function of the ENS give rise to a range of disorders, termed enteric neuropathies and include conditions such as Hirschsprung’s disease. Little is known about the signalling that specifies early ENS progenitors. This has, thus far, limited progress in the generation of enteric neurons from human Pluripotent Stem Cells (hPSCs) that could provide a useful tool for disease modelling and regenerative medicine. We describe the efficient and accelerated generation of ENS progenitors from hPSCs, revealing that retinoic acid is critical for the acquisition of both vagal axial identity and early ENS progenitor specification. These ENS progenitors generate enteric neuronsin vitroand followingin vivotransplantation, achieving long-term colonisation of the ENS in adult mice. Thus, hPSC-derived ENS progenitors may provide the basis for cell therapy for defects in the ENS.