bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing stroke risk stratification in atrial fibrillation through non‐Newtonian blood modelling and Gaussian process emulation
Authors: Melidoro Paolo , Sultan Abdel Rahman Amr , Qureshi Ahmed , Yacoub Magdi H. , Elkhodary Khalil L. , Lip Gregory Y. H. , Montarello Natalie , Lahoti Nishant , Rajani Ronak , Klis Magdalena , Williams Steven E. , Aslanidi Oleg , De Vecchi Adelaide 
Published: December 2024

AbstractAtrial fibrillation (AF) is the most common heart arrhythmia, linked to a five‐fold increase in stroke risk. The left atrial appendage (LAA), prone to blood stasis, is a common thrombus formation site in AF patients. The LAA can be classified into four morphologies: broccoli, cactus, chicken wing and windsock. Stroke risk prediction in AF typically relies on demographic characteristics and comorbidities, often overlooking blood flow dynamics. We developed patient‐specific non‐Newtonian models of blood flow, dependent on fibrinogen and haematocrit, to predict changes in LAA viscosity, aiming to predict stroke in AF patients. We conducted 480 computational fluid dynamics (CFD) simulations using the non‐Newtonian model across the four LAA morphologies for four virtual patient cohorts: AF + Covid‐19, AF + pathological fibrinogen, AF + normal fibrinogen, and healthy controls. Gaussian process emulators (GPEs) were trained on this in silico cohort to predict average LAA viscosity at near‐zero computational cost. GPEs demonstrated high accuracy in AF cohorts but lower accuracy when the chicken wing GPE was applied to other morphologies. Global sensitivity analysis showed fibrinogen significantly influenced blood viscosity in all AF cohorts. The chicken wing morphology exhibited the highest viscosity, while the AF + Covid‐19 cohort had the highest viscosity. Our non‐Newtonian model in CFD simulations confirmed fibrinogen's substantial impact on blood viscosity at low shear rates in the LAA, suggesting that combining blood values and geometric parameters of the LAA into GPE training could enhance stroke risk stratification accuracy.
imageKey points
Fibrinogen has a significant effect on blood viscosity in the left atrial appendage (LAA) at low shear rates.
Gaussian process emulators (GPEs) can predict the viscosity of blood in the LAA at near‐zero computational cost.
Out of all LAA morphologies, the chicken wing morphology exhibited the highest average blood viscosity.
High average blood viscosity in the LAA of atrial fibrilation + Covid‐19 patients was observed due to high fibrinogen levels in this cohort.
Combining blood values and geometric parameters of the LAA into GPE training could enhance stroke risk stratification accuracy.
Use of Right Ventricular Free-Wall Strain in a Multivariable Estimate of Right Ventricular-Arterial Coupling in Pediatric Pulmonary Arterial Hypertension
Authors: Simpkin Charles T. , Ivy D. Dunbar , Friedberg Mark K. , Burkett Dale A. 
Published: December 2024

BACKGROUND:
Right ventricular-arterial coupling (RVAC) describes the relationship between right ventricular contractility and pulmonary vascular afterload. Noninvasive surrogates for RVAC using echocardiographic estimates of right ventricular function, such as tricuspid annular plane systolic excursion (TAPSE), have been shown to correlate with invasively measured RVAC and predict clinical outcomes in pediatric pulmonary arterial hypertension. However, given the limitations of TAPSE at accurately estimating right ventricular function in children, we hypothesized that a multivariable estimate of RVAC using right ventricular free-wall longitudinal strain (RVFW-LS) may perform better than those utilizing TAPSE at predicting clinical outcomes.

METHODS:
In all, 108 children from 2 institutions with pulmonary arterial hypertension underwent hemodynamic catheterization with simultaneous echocardiography. In a retrospective analysis, hybrid (echo and invasive) RVAC metrics included TAPSE/pulmonary vascular resistance (PVRi) and RVFW-LS/PVRi. Noninvasive echocardiographic metrics were TAPSE/echo-derived pulmonary artery systolic pressure (PASP) and RVFW-LS/PASP.

RESULTS:

RVFW-LS correlated with PVRi (r=0.315,
P
=0.01), though TAPSE did not (r=0.058,
P
=0.64). PVRi, PASP, and RVAC metrics declined in patients with worse World Health Organization Functional Class (n=108), while TAPSE and RVFW-LS did not. PVRi, PASP, RVFW-LS/PVRi, TAPSE/PVRi, and RVFW-LS/PASP predicted the outcome variable of transplant or death (area under the curve, 0.771 [
P
<0.001], 0.729 [
P
=0.004], 0.748 [
P
=0.002], 0.732 [
P
=0.009], and 0.714 [
P
=0.01], respectively), while TAPSE/PASP, RVFW-LS, and TAPSE did not (area under the curve, 0.671, 0.603, and 0.525, respectively). In patients without a history of repaired congenital heart disease (n=88), only RVFW-LS/PASP, PVRi, PASP, and RVFW-LS/PVRi predicted outcomes (area under the curve, 0.738 [
P
=0.002], 0.729 [
P
=0.01], 0.729 [
P
=0.01], and 0.729 [
P
=0.015], respectively).

CONCLUSIONS:
In the pediatric population, baseline PVRi and echo-estimated PASP were strongly associated with adverse clinical outcomes, but TAPSE and RVFW-LS were not. Estimates of RVAC utilizing RVFW-LS were superior to those utilizing TAPSE—however, only marginally additive to PASP and PVRi at predicting the adverse clinical outcome in patients without a history of repaired congenital heart disease.
Serum Soluble Fibrinogen-Like Protein 2 Estimates Increased T-Helper 2 Cytokine, Elevated Disease Severity, and Unfavorable Outcomes in Allergic Rhinitis Patients
Authors: Qian Xiaoqiong , Li Danping , Zhang Yu , Su Tiantian , Shi Song 
Published: December 2024

Objective: Soluble fibrinogen-like protein 2 (sFGL2) may be involved in the pathology and progression of allergic rhinitis (AR) through regulating T-helper (Th)2 cell response. This study aimed to explore the ability of sFGL2 to estimate outcomes in AR patients. Methods: sFGL2 was detected in the serum sample of 119 AR patients at baseline and 20 healthy controls (HCs) after enrollment by enzyme-linked immunosorbent assay. In AR patients, disease severity was assessed at baseline as well as 4 weeks (W4) and 8 weeks (W8) after enrollment by the total nasal symptom score (TNSS). Results: sFGL2 was higher in AR patients than HCs [median (interquartile range): 100.0 (70.0-154.0) vs 47.0 (31.5-78.5) ng/mL] ( P < .001). In AR patients, sFGL2 was positively correlated with TNSS score ( P = .002), itching score ( P = .037), sneezing score ( P = .012), and interleukin (IL)-4 ( P = .006) at baseline. TNSS score declined from baseline to W8 in AR patients ( P < .001). To further explore the association between sFGL2 levels and treatment outcomes, we compared the sFGL2 levels between patients with TNSS scores at W4 or W8 >4 and those with TNSS scores at W4 or W8 ≤4. It was found that sFGL2 was only increased in AR patients with a TNSS score at W4 >4 versus those with a TNSS score at W4 ≤4 ( P = .012). Conclusion: Serum sFGL2 is increased in AR patients, and its high level estimates an increased Th2 cytokine and disease severity as well as poor outcomes.
Phytochemical analysis and biogenic synthesis of silver nanoparticles from Phlomis bracteosa Royle ex Benth. and screening of their antimicrobial and antioxidant potential
Authors: Rana Jagriti , Sharma Ankush , Rana Jyoti , Sagar Anand 
Published: December 2024

AbstractThe Phlomis bracteosa Royle ex Benth. is one of the medicinal plants used by the people of the north-western Himalayan region, India. Initially, phytochemical components of this plants have been evaluated by estimating total phenolic, flavonoid and tannin contents, and also by GCMS analysis in acetone and methanol solvents, which listed twenty-four compounds in acetone and twenty-two in methanol extract with different percentage peak areas. Later, silver nanoparticles (SNPs) were biogenically synthesized from the acetone extract of the same plant. The formation of SNPs was observed with UV-vis spectroscopy with surface plasmon resonance (SPR) at 438 nm. Further, the Fourier transform infrared spectroscopy suggested the presence of carbonyls, nitrogenous compounds and different types of hydrocarbons in SNPs. The field emission scanning electron microscopy (FESEM) and the high-resolution transmission electron microscopy suggested the spherical shape of SNPs with average size of 43.53 ± 0.71 nm. On the other hand, the energy dispersive X-ray spectroscopy depicted Ag as major element, the selected area electron diffraction and the X-ray diffraction supported crystalline nature of synthesized SNPs. The antimicrobial and antioxidant activities of both extracts (acetone and methanol) and SNPs were also studied. For the antimicrobial activity analysis, disk diffusion and broth microdilution methods were selected which displayed that plant extracts (PEs) exhibited better activity against Gram-positive bacteria and were inactive against Escherichia coli, while synthesized SNPs displayed better antimicrobial activity against all selected microorganisms. In case of antioxidant activity, by following two methods i.e., DPPH radicle scavenging and reducing power methods again SNPs expressed better antioxidant property with lower IC50 value (40.55 µg/mL) than PEs i.e., 93.48 µg/mL (acetone) and 92.57 µg/mL (methanol). Therefore, biosynthetic SNPs can be a useful strategy in the biomedical sector.
Efficacy of Subsequent Treatments After Disease Progression on CDK4/6 Inhibitors in Patients With Hormone Receptor–Positive Advanced Breast Cancer
Authors: Ravani Lis Victoria , Calomeni Pedro , Vilbert Maysa , Madeira Thiago , Wang Ming , Deng Daxuan , Testa Laura , Colombo Bonadio Renata , Clifton Katherine , Wander Seth A. , Lustberg Maryam 
Published: December 2024

PURPOSE
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6is) combined with endocrine therapy (ET) are the standard of care in hormone receptor–positive/human epidermal growth factor receptor 2–negative (HR+/HER2–) advanced breast cancer (aBC). Yet, disease progression remains common. In the absence of established postprogression sequencing guidelines, we conducted a pooled analysis of Kaplan-Meier (KM)–derived patient data to assess the efficacy of subsequent treatment options after disease progression on CDK4/6i therapy.

METHODS
We conducted a systematic review and meta-analysis searching PubMed, Embase, Cochrane, and conference proceedings for randomized trials and cohort studies published from 2016 to December, 2023. Studies assessing subsequent treatment postprogression on CDK4/6i in patients with HR+ HER2– aBC were included. We performed a pooled analysis of KM-derived individual patient data. Outcomes of interest were progression-free survival (PFS) and overall survival (OS). This study is registered in PROSPERO, CRD42023491090.

RESULTS

Of 12,895 identified records, 18 studies comprising 4,899 patients were included. Maintaining treatment with a CDK4/6i plus ET post–CDK4/6i progression was associated with longer PFS (hazard ratio [HR], 0.61 [95% CI, 0.53 to 0.70];
P
< .01) and prolonged OS (HR, 0.68 [95% CI, 0.60 to 0.77];
P
< .01) compared with ET monotherapy. The PFS benefit was seen in both continuing the previous CDK4/6i (HR, 0.67 [95% CI, 0.56 to 0.79];
P
< .01) and switching to a different CDK4/6i (HR, 0.68 [95% CI, 0.54 to 0.85];
P
< .01). Subsequent therapy with everolimus plus ET achieved similar PFS (HR, 1.10 [95% CI, 0.90 to 1.35];
P
= .35) and significantly shorter OS (HR, 1.52; [95% CI, 1.21 to 1.90],
P
< .01) as compared with ET monotherapy.

CONCLUSION
This extensive data pool suggests significant benefit of CDK4/6i regimens after disease progression as compared with ET monotherapy. Our data also support current guideline recommendations of ET-based therapies over chemotherapy for treatment sequencing.
Fałszywe obietnice bezpieczeństwa?
Authors: Michalski Krzysztof 
Published: December 2024

W artykule dokonano poglądu zagrożeń strukturalnych (organicznych, kombinacyjnych i kumulacyjnych) wynikających z ekspansji i gwałtownego wzrostu złożoności systemów technicznych oraz współczesnych uwarunkowań eksploatacji takich systemów i wprowadzenia technologicznych innowacji. Wobec społecznej rosnącej awersji do sąsiedztwa instalacji technicznych i produktów przemysłowych oraz rosnącej nieufności do naukowych poświadczeń bezpieczeństwa autor artykułu poszukuje odpowiedzi na pytanie, czy społeczne obawy przed niebezpieczeństwami czynników technicznych są zasadne. Na podstawie teoretycznej analizy strategii poznawczych w wybranych domenach działalności technicznych autor wykazuje, że część zagrożeń jest poznawczo nieuchwytna dla normalnej nauki. Jako przyczyny wymienia ograniczenia poznawcze, błędy, ułomności i nadużycia, które podważają wiarygodność naukowych poświadczeń bezpieczeństwa i skłaniają do gruntownej rewizji dotychczasowych strategii poznawczych. Autor postuluje zastąpienie procedur ekspercko-laboratoryjnych normalnej nauki modelami postnormalnymi, opartymi na uzgodnieniach z osobami narażonymi.
The Impact of Mobile Data Cost on Consumer Price Sensitivity: A Study of a Hotel Booking App
Authors: Luo Xiaopeng , He Cheng , Hu Yu Jeffrey , Li Xitong , Cheng Yuan 
Published: December 2024

The Impact of Mobile Data Cost on Consumer Price Sensitivity: A Study of a Hotel Booking App Mobile data cost arises from the perception that mobile data are more expensive than Wi-Fi because of additional charges incurred when exceeding fixed data quotas. Understanding mobile data cost is a global and industry-wide concern as the perception of this cost is common in both developed and developing countries, and even subtle behavioral shifts because of this cost can have significant impacts given the prevalence of mobile shopping. Using hotel search data, we find that consumers are approximately twice as price sensitive when using mobile data compared with Wi-Fi, leading to an average revenue reduction of $17 per hotel booking. Additionally, consumer search effort decreases across decision stages when using mobile data rather than Wi-Fi, showing that mobile data users pursue satisfactory options without extensive search effort, obtain less product information, and therefore rely more on price information, becoming more price sensitive. This study provides implications for mobile shopping environments in which limited mobile data plans are common, suggesting that firms should consider consumers’ connectivity types in marketing strategies, offer data subsidies to encourage more thorough searches, and develop customized recommendations and app versions for mobile data users and that policymakers should monitor potential price discrimination to protect consumer interests.
The Adult Orthodontic–Restorative Interface. Part 3: Dental Trauma and Acquired Disease
Authors: Smith Robert , Stagles Christopher , Bryce Graeme 
Published: December 2024

Part 3 of this three-part series outlines the specific challenges associated with providing orthodontic–restorative treatment in adult patients experiencing dentitions injured by dental trauma or acquired disease. CPD/Clinical Relevance: Optimal management of patients with injured dentitions may necessitate a joint orthodontic–restorative approach.
Swelling Misattributed to an Infected Tooth Socket
Authors: Mazurkeviciute Migle , Toon Grace , Carter Emily 
Published: December 2024

This is a case report of a patient seen on the dental emergency clinic that describes ophthalmic shingles reactivation soon after a tooth extraction with the potential to have led to a misdiagnosis of the condition. This can potentially have serious consequences, including effects on vision. This case report emphasizes the importance of a thorough history and careful examination when a patient presents in an urgent setting. CPD/Clinical Relevance: The importance of a thorough history and careful examination is highlighted.
This is How We are at Home: Typology and Shifting Parenting Authority in Early Childhood
Authors: Sapendi Sapendi , Suratman Bayu 
Published: December 2024

Purpose – Parenting Islamism not only makes religion a teaching material in children’s education, but more than that, religion is used as an ideology that displays Islamic symbols in parenting actions in the public sphere. The emergence of Islamism parenting practices is a response to traditional parenting practices and modern parenting practices. This study aims to explore the practice of parenting in millennial families based on the ideology of Islamism in Pontianak City. Design/methods/approach – This research method uses the Mixed Methods Research approach, which is a combination of qualitative and quantitative methods. The qualitative method in this study provides an understanding of the shifting in parenting authority carried out by millennial parents with the ideology of Islamism. Meanwhile, the quantitative is carried out to measure the variables of parenting typology objectively. Data analysis in this study was carried out; first, the data was reduced; second, data categorization; third, data preparation; fourth, data verification; fifth, the configuration of the relationship between the inference of the problem formulation; sixth, the data is analyzed with theory. Findings – The findings of this study show that millennial parents of Islamism groups use mixed parenting, which is a combination of several parenting models according to the condition of the child, be it authoritarian, authoritative, and permissive. The findings of this study also show that there is a shift in parenting authority in Islamism millennial families, which is influenced by new media so that parents idolize popular ustadz from Islamism groups. Research implications/limitations – The shift in authority in parenting has implications for parental figures or references in parenting due to the presence of new authorities on social media, namely public figures or micro-celebrities. This research is not final, and there are still many limitations in relevant cases, informants, and theories, so further research is needed to accommodate other new findings in parenting studies in millennial families of Islamism groups with a larger number of informants in Indonesia. Practical implications – This study shows that parenting practices carried out by parents are inseparable from religious ideology, which has an impact on parenting in early childhood. This study emphasizes that parenting practices in Muslim parents are not uniform, even in religiously homogeneous families. Originality/value – This study provides a new perspective in parenting studies because it examines from the perspective of parents’ religious ideology. Paper type Research paper
The Role of English Language in Hotel Marketing in Sulaymaniyah, Kurdistan Region of Iraq
Authors: Qadir Karzan J. , Salah Khelan M. , Badawi Soran S. 
Published: December 2024

The English language plays a pivotal role in enhancing the effectiveness of hotel marketing efforts. In this study, we endeavor to investigate the significance of the English language in hotel marketing for both hotel managers and employees. The study utilizes a quantitative approach in its methodology. The study involved a sample of 15 managers and 35 employees who were asked to complete a structured Likert questionnaire to provide insights. The collected data was analyzed using the SPSS software. The statistical results of the study revealed that managers consider their business performance to be moderately good. The results also highlight a weak negative correlation between English language usage and business performance, suggesting that as the integration of the English language increases, business performance tends to slightly decline. There is also a positive, although not very strong, linear relationship between English language proficiency and career and job opportunities. These findings provide valuable insights into the intricate dynamics of language usage in the hospitality industry and offer implications for marketing strategies and employee skill development. As such, this study can serve as a useful guide for hotel managers and other stakeholders seeking to enhance their marketing efforts and improve their employees' language skills
بنه‌ماكانی داڕشتنی‌ زاراوه‌ی یاسایی له‌ زمانی كوردیدا‌
Authors: Sabir Shadan SH. , عەبدوڵا ڕۆژان نوری 
Published: December 2024

پوخته‌:
توێژینه‌وه‌كه‌ به‌ ناونیشانی (بنه‌ماكانی داڕشتنی‌ زاراوه‌ی یاسایی له‌ زمانی كوردیدا‌)یه‌، هۆی هه‌ڵبژاردنی ئه‌م بابه‌ته‌ بۆ ئه‌وه‌ ده‌گه‌ڕێته‌وه‌، كه‌ تاكو ئێستا ئه‌م بابه‌ته‌ له‌ زمانی كوردیدا، كاری له‌سه‌رنه‌كراوه‌، ئێمه‌ ده‌مانه‌وێت‌ له‌ڕێگای ئه‌م توێژینه‌وه‌یه‌وه‌ ئه‌م بۆشاییه‌ پڕبكه‌ینه‌وه‌ و ده‌وڵه‌مه‌ندی زمانی كوردی له‌ڕوی زاراوه‌ی یاساییه‌وه‌ بخه‌ینه‌ڕ، ئه‌م توێژینه‌وه‌یه‌ به‌ ڕێبازی‌ وه‌سفی شیكاریی هه‌وڵی ده‌ستنیشانكردن و خستنه‌ڕوی بنه‌ماكانی داڕشتنی‌ زاراوه‌ی یاسایی داوه‌، پشتبه‌ستوو به‌ هێنانه‌وه‌ و شیكردنه‌وه‌ی چه‌ندین نمونه‌ له‌ بواری یاسا له‌ زمانی كوردیدا. چونكه‌ زمان به‌كارهێنانی تایبه‌تی له‌ بواره‌ جیاوازه‌ زانستی و ئه‌كادیمییه‌كاندا هه‌یه‌، زمانی یاساش، كه‌ زمانێكى پسپۆڕیی و تایبەتمه‌ندە، بە زاراوە و واتا وردەکانی جیادەکرێتەوە.
گرنگترین ئەنجامەکانی توێژینەوەکە بریتین لە: بۆ ئەوەی مافەکان بچەسپێن و ئەرکەکان جێبەجێ بکرێن، پێویستە لەسەر یاسادانەر، یان هەر کەسێک، کەمامه‌ڵه‌ لەگەڵ دەقی یاسایی ده‌كات، ڕەچاوی ڕێساکانی زمان بکات و گرنگی پێ بدات، چونكه‌ دەقی یاسایی داڕشتەیەکە، ئەگەر بە باشی دابڕژێت و ڕەچاوی ڕێزمان و یاساكانی زمانی تێدا بکرێت ئامانجەکەی دەپێکێت. زمانی كوردی زمانێكی گونجاوه‌ بۆ بواری یاسا، چونكه‌ توانای پڕكردنه‌وه‌ی پێداویستییه‌كانی و ده‌وڵه‌مه‌ندكردنی فه‌رهه‌نگی بواره‌كه‌ی‌ هه‌یه‌ له‌ ڕێگای كۆمه‌ڵێك بنه‌مای وه‌ك: بنه‌مای (داڕشتن، لێكدان، ده‌سته‌ وشه‌، داتاشین، وه‌رگرتن، كورتبڕی، پێوانه‌كردن، میتافۆر و وه‌رگێڕان)ه‌وه‌. بنه‌مای (داڕشتن، لێكدان، ده‌سته‌ وشه‌، داتاشین، وه‌رگرتن، وه‌رگێڕان)‌ چالاكترین و به ‌بڕشترین بنه‌مان بۆ دروستكردنی زاراوه‌ی یاسایی، به‌ڵام بنه‌مای (كورتبڕی، میتافۆر و داتاشین) له‌ داڕشتنی زاراوه‌ی یاسایی‌ ناچالاكن.
القياس الاقتصادي لأثر التجارة الدولية والنمو الصناعي لدول اسيان للمدة1990 -2020
Authors: نجيب شيماء محمد 
Published: December 2024

تعد تجربة الاوز الطائر من التجارب التصنيعية الناجحة التي حذت بالاقتصادات الاسيوية الى التطور من خلال استخدام استراتيجية تعتمد على التنمية الصناعية وتستند الى التغير الهيكلي في القطاع الصناعي وبدعم ومراقبة عالية من قبل الدول المستخدمة لهذه التجربة من خلال الانتاج المعد من اجل اعداده للتصدير مع مراعاة الوضع التنافسي للسلع ، يهدف البحث الى تشخيص الاسباب والعوامل التي ادت الى نضج التنمية الصناعية في دول اسيان المتبعة تجربة الاوز الطائر، كما ويوضح البحث اهمية التجارة الدولية من خلال اتباع التصنيع من اجل التصدير. وتناولت فرضية البحث ، ان التجارة الدولية ساهمت من خلال اتباع التصنيع من اجل التصدير الى جانب عوامل اقتصادية اخرى مساهمة فعالة في الوصول الى نمو صناعي في دول جنوب شرق اسيا .توصل البحث الى عدد من الاستنتاجات ومنها اهمية اتباع الدول النامية مثل هذه التجربة الناجحة لتحقيق النمو الصناعي ، كما وتبين الدراسة النظرية لانموذج الاوز الطائر توجه الاقتصاد الياباني الى بناء حزام صناعي قوي مع الدول المجاورة لبلدان جنوب شرق اسيا الحديثة التصنيع مستخدما بذلك اليات متعددة ومنها الترحيل المتسارع للمنشآت الصناعية الانتاجية نحو البلدان الاسيوية للمحافظة عالى تنافسية السلع الصناعية ، كما و قدم عدة مقترحات ومنها ضرورة اتباع تصحيح الهيكل الصناعي وفق إستراتيجية تعتمد على التصنيع لاجل التصدير في البلدان النامية سواء ابتدئنا بالصناعات الخفيفة او الصناعات الثقيلة كما لاحظنا في نموذج الاوز الطائر الذي ابتدا بتصنيع المنسوجات القطنية واستورد المادة الخام من بريطانيا.