bluuebunny/crossref_metadata_2025_split huggingface dataset:
Behavior of alginate–gelatin blended gel with embedded macrovoids: Stress‐induced changes and the solute release characteristics
Authors: Banerjee Arindam , Ganguly Somenath 
Published: January 2020

AbstractBlending of gelatin to alginate promote cell–material interaction. However, the changes in diffusive and mechanical properties need to be ascertained. This study shows that the presence of two superposed polymer networks, where gelatin is not additionally crosslinked resulted in higher uptake and slower release of vitamin B12. In the presence of gelatin, the stress is found higher for the same level of compressive deformation, and the permeability of the pore fluid during expulsion under compressive stress is found significantly lower. Also, a large residual strain at the end of each cycle in case of cyclic compression is observed, when gelatin is present. A microfluidic device is used to introduce voids uniformly across the blended gel with an objective to increase compressibility, permeability (for faster equilibration of pore pressure), and uptake of bioactive species. The results showing lower permeability and higher uptake in the presence of gelatin are discussed.
Photoinitiated Thiol−Ene Reactions of Various 2,3‐Unsaturated O‐, C‐ S‐ and N‐Glycosides – Scope and Limitations Study
Authors: Kelemen Viktor , Csávás Magdolna , Hotzi Judit , Herczeg Mihály , Poonam  , Rathi Brijesh , Herczegh Pál , Jain Nidhi , Borbás Anikó 
Published: January 2020

AbstractThe photoinitiated thiol−ene addition reaction is a highly stereo‐ and regioselective, and environmentally friendly reaction proceeding under mild conditions, hence it is ideally suited for the synthesis of carbohydrate mimetics. A comprehensive study on UV‐light‐induced reactions of 2,3‐unsaturated O‐, C‐, S‐ and N‐glycosides with various thiols was performed. The effect of experimental parameters and structural variations of the alkenes and thiols on the efficacy and regio‐ and stereoselectivity of the reactions was systematically studied and optimized. The type of anomeric heteroatom was found to profoundly affect the reactivity of 2,3‐unsaturated sugars in the thiol−ene couplings. Hydrothiolation of 2,3‐dideoxy O‐glycosyl enosides efficiently produced the axially C2‐S‐substituted addition products with high to complete regioselectivity. Moderate efficacy and varying regio‐ and stereoselectivity were observed with 2,3‐unsaturated N‐glycosides and no addition occurred onto the endocyclic double bond of C‐glycosides. Upon hydrothiolation of 2,3‐unsaturated S‐glycosides, the addition of thiyl radicals was followed by elimination of the thiyl aglycone resulting in 3‐S‐substituted glycals.
Enhancing Ru(II)‐Catalysis with Visible‐Light‐Mediated Dye‐Sensitized TiO2 Photocatalysis for Oxidative C−H Olefination of Arene Carboxylic Acids at Room Temperature
Authors: Dana Suman , Dey Purusattam , Patil Siddappa A. , Baidya Mahiuddin 
Published: January 2020

AbstractErythrosine B sensitized TiO2 photocatalysis has been combined with Ru(II)‐catalysis to accomplish an oxidative olefination/annulation of benzoic acids with activated olefins under mild conditions that tolerates useful functionalities, such as halides, free hydroxy, acetamido, etc. The morphology of the photocatalyst is unaffected during the reaction and it can be reused. Mechanistic studies favor the involvement of a photo‐induced single electron transfer process.
Estimation in the Cox survival regression model with covariate measurement error and a changepoint
Authors: Agami Sarit , Zucker David M. , Spiegelman Donna 
Published: January 2020

AbstractThe Cox regression model is a popular model for analyzing the relationship between a covariate vector and a survival endpoint. The standard Cox model assumes a constant covariate effect across the entire covariate domain. However, in many epidemiological and other applications, the covariate of main interest is subject to a threshold effect: a change in the slope at a certain point within the covariate domain. Often, the covariate of interest is subject to some degree of measurement error. In this paper, we study measurement error correction in the case where the threshold is known. Several bias correction methods are examined: two versions of regression calibration (RC1 and RC2, the latter of which is new), two methods based on the induced relative risk under a rare event assumption (RR1 and RR2, the latter of which is new), a maximum pseudo‐partial likelihood estimator (MPPLE), and simulation‐extrapolation (SIMEX). We develop the theory, present simulations comparing the methods, and illustrate their use on data concerning the relationship between chronic air pollution exposure to particulate matter PM10 and fatal myocardial infarction (Nurses Health Study (NHS)), and on data concerning the effect of a subject's long‐term underlying systolic blood pressure level on the risk of cardiovascular disease death (Framingham Heart Study (FHS)). The simulations indicate that the best methods are RR2 and MPPLE.
Successful brentuximab vedotin monotherapy against late relapse of classical Hodgkin lymphoma 6 years after first remission
Authors: Nagashima Kana , Kikuchi Shohei , Iyama Satoshi , Fujita Chisa , Goto Akari , Horiguchi Hiroto , Kobune Masayoshi 
Published: January 2020

AbstractBrentuximab vedotin monotherapy for late‐relapse CHL is a promising therapeutic with sustained CR benefit and avoiding potential toxicities caused by aPBSCT/HDT.
A new approach for handling missing correlation values for meta‐analytic structural equation modeling: Corboundary R package
Authors: Ahn Soyeon , Abbamonte John M. 
Published: January 2020

AbstractWith increased use of multivariate meta‐analysis in numerous disciplines, where structural relationships among multiple variables are examined, researchers often encounter a particular challenge due to missing information. The current research concerns missing correlations (rs) in the correlation matrix of m variables (Rm × m) and establish more informative and empirical prior distributions for missing rs in Rm × m. In particular, the method for deriving mathematically/analytically boundaries for missing rs in relation to other adjacent rs in Rm × m, while satisfying conditions for a valid Rm × m (i.e., a symmetric and positive semidefinite correlation matrix containing real numbers between −1 and 1) is first discussed. Then, a user‐defined R package for constructing the empirical distributions of boundaries for rs in Rm × m is demonstrated with an example. Furthermore, the applicability of constructing empirical boundaries for rs in Rm × m beyond multivariate meta‐analysis is discussed.
Identification of Lyve‐1 positive macrophages as resident cells in meninges of rats
Authors: Brezovakova Veronika , Jadhav Santosh 
Published: January 2020

AbstractMeningeal immunity along with its associated lymphatic vasculatures is widely discussed recently. Lymphatic vessels in meninges drain interstitial fluid into the deep‐cervical lymph nodes. The vessels are composed of cells that express the cardinal marker for lymphatic endothelium—the lymphatic vessel hyaluronan receptor‐1 (Lyve‐1). However, studies also show the presence of nonendothelial Lyve‐1 expressing cells in certain tissues. Therefore, we were curious if nonendothelial Lyve‐1+ cells are also present in dura mater of meninges. We show that Lyve‐1+ endothelial cells are distributed adjacent to the blood vessels in the brain dura mater of rats. We did not observe any lymphatic vessels in spinal dura mater. Interestingly, we also observed isolated population of nonlymphatic Lyve‐1+ cells in both brain and spinal dura mater. Morphologically, the Lyve‐1+ cells were extensively pleomorphic, sometimes elongated or round. Surprisingly, the thoracolumbal meningeal Lyve‐1+ cells were predominantly round in morphology. Using endothelial specific marker VEGFR3 and macrophage markers CD68 and CD169, we observed that the isolated Lyve‐1+ cells lacked endothelial cell signature, but were either CD68+ or CD169+ macrophages. Moreover, we observed that the Lyve‐1+ cells colocalized with collagen fibers in the meninges, and some of Lyve‐1+ cells had intracellular collagen. The study for the first time demonstrates the presence of Lyve‐1 positive macrophages in the lymphatic and nonlymphatic regions in the meninges of rats.
Experimental verification of a hybrid multilevel inverter with voltage‐boosting ability
Authors: Shiva Naik Banavath , Suresh Yellasiri , Venkataramanaiah Jammala 
Published: January 2020

SummaryA new nine‐level natural‐balanced boost hybrid multilevel inverter (BH‐MLI) is proposed in this paper. Each phase of the proposed BH‐MLI is designed with only 11 semiconductor switches and two electrolytic capacitors. Here, the capacitor voltages are balanced by utilizing the series‐parallel and natural balancing techniques effectively. Furthermore, the proposed circuit eradicates the multiple DC sources by introducing a single DC link for single‐ and three‐phase applications. The proposed topology can be easily extendible to obtain higher level output voltage waveform due to its modular‐switched capacitor cells (SCCs). Besides, the higher voltage level generation does not pose high‐voltage stress on any of the topology components, as the blocking voltage of all devices within the source voltage magnitude. Further, a quantitative comparison is conducted among the state‐of‐art switched‐capacitor multilevel inverter (SC‐MLIs) to highlight the superiority of the proposed configuration. Finally, the performance of the proposed BH‐MLI is experimentally validated with phase disposition‐pulse width modulation (PD‐PWM) and round control method at different modulation indices, load conditions.
Prenatal maternal hair cortisol concentrations are related to maternal prenatal emotion dysregulation but not neurodevelopmental or birth outcomes
Authors: Conradt Elisabeth , Shakiba Nila , Ostlund Brendan , Terrell Sarah , Kaliush Parisa , Shakib Julie H. , Crowell Sheila E. 
Published: January 2020

AbstractHair cortisol concentrations measured during pregnancy have emerged as a novel biomarker for prenatal stress exposure. However, associations between prenatal stress and distress, broadly defined, and hair cortisol concentrations during pregnancy are inconsistent. We examined relations among hair cortisol concentrations during the third trimester with (a) emotion dysregulation and (b) detailed measures of maternal prenatal stress. We also examined the predictive validity of maternal hair cortisol during pregnancy for adverse newborn health outcomes. Cortisol concentrations were derived from 6 cm of hair during the third trimester of pregnancy. Mothers reported on their emotion dysregulation and stress at this time. A standardized newborn neurobehavioral exam was conducted shortly after birth and newborn birth weight and gestational age were assessed from medical records. All hypotheses were preregistered on the Open Science Framework (osf.io/279ng). High levels of emotion dysregulation, but not stress, were predictive of high hair cortisol concentrations. Maternal prenatal BMI mediated the relation between maternal prenatal emotion dysregulation and hair cortisol concentrations. There was no association between hair cortisol and infant birth outcomes. This research supports the notion that transdiagnostic markers of psychopathology are important correlates of hair cortisol concentrations during pregnancy.
Anthropogenic disturbance drives dispersal syndromes, demography, and gene flow in amphibian populations
Authors: Cayuela Hugo , Besnard Aurélien , Cote Julien , Laporte Martin , Bonnaire Eric , Pichenot Julian , Schtickzelle Nicolas , Bellec Arnaud , Joly Pierre , Léna Jean‐Paul 
Published: January 2020

AbstractThere is growing evidence that anthropogenic landscapes can strongly influence the evolution of dispersal, particularly through fragmentation, and may drive organisms into an evolutionary trap by suppressing dispersal. However, the influence on dispersal evolution of anthropogenic variation in habitat patch turnover has so far been largely overlooked. In this study, we examined how human‐driven variation in patch persistence affects dispersal rates and distances, determines dispersal‐related phenotypic specialization, and drives neutral genetic structure in spatially structured populations. We addressed this issue in an amphibian, Bombina variegata, using an integrative approach combining capture–recapture modeling, demographic simulation, common garden experiments, and population genetics. B. variegata reproduces in small ponds that occur either in habitat patches that are persistent (i.e., several decades or more), located in riverine environments with negligible human activity, or in patches that are highly temporary (i.e., a few years), created by logging operations in intensively harvested woodland. Our capture–recapture models revealed that natal and breeding dispersal rates and distances were drastically higher in spatially structured populations (SSPs) in logging environments than in riverine SSPs. Population simulations additionally showed that dispersal costs and benefits drive the fate of logging SSPs, which cannot persist without dispersal. The common garden experiments revealed that toadlets reared in laboratory conditions have morphological and behavioral specialization that depends on their habitat of origin. Toadlets from logging SSPs were found to have higher boldness and exploration propensity than those from riverine SSPs, indicating transgenerationally transmitted dispersal syndromes. We also found contrasting patterns of neutral genetic diversity and gene flow in riverine and logging SSPs, with genetic diversity and effective population size considerably higher in logging than in riverine SSPs. In parallel, intrapatch inbreeding and relatedness levels were lower in logging SSPs. Controlling for the effect of genetic drift and landscape connectivity, gene flow was found to be higher in logging than in riverine SSPs. Taken together, these results indicate that anthropogenic variation in habitat patch turnover may have an effect at least as important as landscape fragmentation on dispersal evolution and the long‐term viability and genetic structure of wild populations.
Toward Validation of Toxicological Interpretation of Diffusive Gradients in Thin Films in Marine Waters Impacted by Copper
Authors: Strivens Jonathan , Hayman Nicholas , Rosen Gunther , Myers-Pigg Allison 
Published: January 2020

Abstract
Determination of the median effective concentration (EC50) of Cu on Mytilus galloprovincialis larvae by diffusive gradient in thin films (DGT) has been shown to effectively reduce the need to consider dissolved organic carbon (DOC) concentration and quality. A standard toxicity test protocol was used to validate previously modeled protective effects, afforded to highly sensitive marine larvae by ligand competition, in 5 diverse site waters. The results demonstrate significant narrowing of M. galloprovincialis toxicological endpoints, where EC50s ranged from 3.74 to 6.67 μg/L as CDGT Cu versus 8.76 to 26.8 μg/L as dissolved Cu (CuDISS) over a DOC range of 0.74 to 3.11 mg/L; Strongylocentrotus purpuratus EC50s were 10.5 to 19.3 μg/L as CDGT Cu versus 22.7 to 67.1 μg/L as CuDISS over the same DOC range. The quality of DOC was characterized by fluorescence excitation and emission matrices. The results indicate that the heterogeneity of competing Cu binding ligands, in common marine waters, minimizes the need for class determinations toward explaining the degree of protection. Using conservative assumptions, an M. galloprovincialis CDGT Cu EC50 of 3.7 µg/L and corresponding criterion maximum concentration CDGT Cu of 1.8 µg/L, for universal application by regulatory compliance-monitoring programs, are proposed as a superior approach toward both integration of dynamic water quality over effective exposure periods and quantification of biologically relevant trace Cu speciation. Environ Toxicol Chem 2020;39:873–881. © 2020 SETAC
Index options open interest and stock market returns
Authors: Seo Sung Won , Byun Suk Joon , Kim Jun Sik 
Published: January 2020

AbstractThis study finds that the growth of index options open interest has a significant relation with future stock market returns. We propose a theoretical model that considers hedgers and informed traders in the options market and suggests that hedgers fully utilize options according to their expectations of future stock returns. The empirical results show that the growth of out‐of‐the‐money call options open interest is significantly related with future stock market returns. These findings provide supporting evidence for our theoretical model.
Short and long TNF‐alpha exposure recapitulates canonical astrogliosis events in human‐induced pluripotent stem cells‐derived astrocytes
Authors: Trindade Pablo , Loiola Erick Correia , Gasparotto Juciano , Ribeiro Camila Tiefensee , Cardozo Pablo Leal , Devalle Sylvie , Salerno José Alexandre , Ornelas Isis Moraes , Ledur Pitia Flores , Ribeiro Fabiola Mara , Ventura Ana Lucia Marques , Moreira José Claudio Fonseca , Gelain Daniel Pens , Porciúncula Lisiane Oliveira , Rehen Stevens Kastrup 
Published: January 2020

AbstractAstrogliosis comprises a variety of changes in astrocytes that occur in a context‐specific manner, triggered by temporally diverse signaling events that vary with the nature and severity of brain insults. However, most mechanisms underlying astrogliosis were described using animals, which fail to reproduce some aspects of human astroglial signaling. Here, we report an in vitro model to study astrogliosis using human‐induced pluripotent stem cells (iPSC)‐derived astrocytes which replicate temporally intertwined aspects of reactive astrocytes in vivo. We analyzed the time course of astrogliosis by measuring nuclear translocation of NF‐kB, production of cytokines, changes in morphology and function of iPSC‐derived astrocytes exposed to TNF‐α. We observed NF‐kB p65 subunit nuclear translocation and increased gene expression of IL‐1β, IL‐6, and TNF‐α in the first hours following TNF‐α stimulation. After 24 hr, conditioned media from iPSC‐derived astrocytes exposed to TNF‐α exhibited increased secretion of inflammation‐related cytokines. After 5 days, TNF‐α‐stimulated cells presented a typical phenotype of astrogliosis such as increased immunolabeling of Vimentin and GFAP and nuclei with elongated shape and shrinkage. Moreover, ~50% decrease in aspartate uptake was observed during the time course of astrogliosis with no evident cell damage, suggesting astroglial dysfunction. Together, our results indicate that human iPSC‐derived astrocytes reproduce canonical events associated with astrogliosis in a time dependent fashion. The approach described here may contribute to a better understanding of mechanisms governing human astrogliosis with potential applicability as a platform to uncover novel biomarkers and drug targets to prevent or mitigate astrogliosis associated with human brain disorders.
Can your house keep you out of a nursing home?
Authors: Diepstraten Maaike , Douven Rudy , Wouterse Bram 
Published: January 2020

AbstractWe examine the impact of the accessibility of an older individual's house on her use of nursing home care. We link administrative data on the accessibility of all houses in the Netherlands to data on long‐term care use of all older persons from 2011 to 2014. We find that older people living in more accessible houses are less likely to use nursing home care. The effects increase with age and are largest for individuals aged 90 or older. The effects are stronger for people with physical limitations than for persons with cognitive problems. We also provide suggestive evidence that older people living in more accessible houses substitute nursing home care by home care.
Becoming an Author: Engaging High School Students in Disciplinary Practices
Authors: García‐Verdugo Lorvic , López‐Bonilla Guadalupe 
Published: January 2020

AbstractIt is generally considered that students who want to become scientists engage in scientific practices as university students, particularly when pursuing postgraduate studies. However, schools and teachers can help students participate in authentic scientific and disciplinary practices, such as data sampling and analysis, in high school. The authors explore the case of a Mexican high school student whose experience in becoming a published scientific author was afforded through the synergy of different factors, such as a specific school’s curriculum, a teacher’s pedagogy based on his real experience as a scientist, and an institutional context that favors scientific endeavors. The findings are discussed based on Moje’s framework of common disciplinary practices and Knorr‐Cetina’s definition of habitual and epistemic practices.
Tcf3‐activated lncRNA Gas5 regulates newborn mouse cardiomyocyte apoptosis in diabetic cardiomyopathy
Authors: Su Dongsheng , Ju Yansong , Han Wei , Yang Yanhua , Wang Fengyun , Wang Tong , Tang Jianmin 
Published: January 2020

AbstractDiabetic cardiomyopathy can cause cardiac dysfunction and eventually lead to heart failure and sudden death. Long noncoding RNA (lncRNA) Gas5 has been reported to play a function in cardiomyocyte. Here we studied the function of Gas5 on newborn mouse cardiomyocyte (NMC) apoptosis to detect its molecular mechanism. High‐glucose treatment was implemented to induce the apoptosis of NMC in this study. And terminal deoxynucleotidyl transferase dUTP nick‐end labeling assay, JC‐1 assay, and flow cytometry analysis were conducted to know about the apoptosis of NMC when Gas5 and Tcf3 were silenced. Meanwhile, RNA pull‐down assay and luciferase reporter assay were conducted to verify the binding of RNAs. Finally, rescue assay was implemented to evaluate the influence on apoptosis situation affected by competing endogenous RNA pathways. Tcf3 was found to bind to the Gas5 promoter to activate the expression of Gas5. Meanwhile, Gas5 and Tcf3 were both found to promote the apoptosis of NMC. Also, mmu‐miR‐320‐3p could bind to Gas5 and Tcf3. Moreover, the Gas5/miR‐320‐3p/Tcf3 pathway was found to modulate the apoptosis of NMC. In conclusion, Tcf3‐activated lncRNA Gas5 regulates NMC apoptosis in diabetic cardiomyopathy.
Stromal‐epithelial interactions in prostate cancer: Overexpression of PAGE4 in stromal cells inhibits the invasive ability of epithelial cells
Authors: Fu Shui , Liu Tao , Lv Chengcheng , Fu Cheng , Zeng Ruoheng , Kakehi Yoshiyuki , Kulkarni Prakash , Getzenberg Robert H. , Zeng Yu 
Published: January 2020

AbstractIt is now widely recognized that carcinoma‐associated fibroblasts which are believed to be myofibroblasts, promote the transformation of prostate epithelial cells to cancer cells, enhance their proliferation and invasiveness, and induce the acquisition of resistance to cancer therapy and immune evasiveness. Prostate‐associated gene 4 (PAGE4) is an intrinsically disordered protein that is remarkably prostate‐specific. PAGE4 is also a stress‐response protein that functions as a transcriptional regulator and is upregulated in early‐stage prostate cancer (PCa) and its precursor lesions. However, PAGE4 is downregulated in high‐grade PCa and metastatic disease. Here, we show that PAGE4 is highly expressed in the stromal cells surrounding the cancer‐adjacent “normal” glands and low‐grade PCa lesions but not in lesions proximal to high‐grade PCa. Overexpression of PAGE4 in a stromal cell line inhibits the migration and invasion of PCa epithelial cells in multiple coculture systems. PAGE4 overexpression also inhibits the downregulation of E‐cadherin in PCa epithelial cells when cocultured with stromal cells. Furthermore, signaling via tumor necrosis factor‐α and transforming growth factor‐β pathways is decreased in the stromal cells overexpressing PAGE4 suggesting that PAGE4 appears to play a protective role against disease progression by perturbing interactions between epithelial cells and stromal cells in PCa. Taken together, these findings support previous observations that upregulation of PAGE4 in PCa correlates with a better prognosis and highlight PAGE4 as a novel therapeutic target for early‐stage “low‐risk” disease.