bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Capsular Closure on Outcomes of Hip Arthroscopy for Femoracetabular Impingement: A Systematic Review and Meta‐analysis
Authors: Liu Liang , Zhang Yan , Gui Qi , Zhao Feng , Shen Xue‐Zhen , Zhang Xing‐Huo , Cong Xiao‐Peng , Zhang Ya‐Kui 
Published: June 2020

ObjectiveTo evaluate the effect of hip arthroscopy with or without capsular closure in femoracetabular impingement (FAI) by meta‐analysis.MethodsPertinent studies were identified by searching Pubmed, EMBASE databases with the last search update on 16 February 2020. Studies that reported hip arthroscopy for FAI were collected. Meta‐analysis was performed by the use of Review Manager 5.3 software. The odds ratios (OR) and mean differences (MD) were used to compare dichotomous and continuous variables. Additionally, the I2 was used to assess heterogeneity among studies, and the fixed‐effects model or the random‐effects model was selected for the quantitative analysis. Outcomes were evaluated by forest plots. For statistical analysis, P < 0.05 was considered significant.ResultsThere was no significant difference among the preoperative mHHS (MD = –2.66，95% CI [−7.25, 1.92], I2 = 80%, P = 0.25), preoperative (MD = ‐4.94, 95% CI [−11.56, 1.67], I2 = 50%, P = 0.14) and postoperative HOS‐SSS (MD = ‐1.00, 95% CI [−6.98, 4.98], I2 = 66%, P = 0.74), patient satisfaction (MD = 0.03, 95% CI [−0.25, 0.31], I2 = 19%, P = 0.84; OR = 0.94, 95% CI [0.59, 1.50], I2 = 0%, P = 0.78), complications (OR = 1.23, 95%CI [0.56, 2.67], I2 = 0%, P = 0.61), revisions (OR = 1.77, 95% CI [0.87, 3.60], I2 = 36%, P = 0.11), and surgery time (SMD = –0.38, 95% CI [−1.16, 0.40], I2 = 92%, P = 0.34) between the capsule closure group and the non‐closure group. For the comparison of postoperative mHHS (MD = –2.66, 95% CI [−7.25, 1.92], I2 = 80%, P = 0.25) and HOS‐ADL (MD = ‐4.20, 95% CI [−5.75, −2.65], I2 = 24%, P < 0.00001), the score of the non‐closure group was significantly better than that of the closure group.ConclusionsRemain capsule unclosed after hip arthroscopy for FAI may, to some extent, has a better postoperative functional score than the non‐closure treatment.
Patient‐by‐patient basis anti‐tachycardia pacing for fast ventricular tachycardia with structural heart diseases
Authors: Chinushi Masaomi , Furushima Hiroshi , Saitoh Osamu , Noda Takashi , Nitta Takashi , Aizawa Yoshifusa , Ohe Tohru , Kurita Takashi 
Published: June 2020

AbstractBackgroundAnti‐tachycardia pacing (ATP) delivered from an implantable device is an important tool to terminate ventricular tachycardia (VT). But its real‐world efficacy for fast VT has not been fully studied.MethodsUsing the database of Nippon‐storm study, effect of patient‐by‐patient basis ATP programming for fast VT (≥188 bpm) was assessed for the patients with structural heart diseases. Fast VTs were divided into three groups depending on heart rate (HR); Group A was 188–209 bpm, and Group‐B and Group‐C were 210‐239 bpm and ≥240 bpm, respectively.ResultsDuring a median follow‐up of 28 months, 202 fast VT episodes (209 ± 19 bpm) were demonstrated in the 85 patients. ATP terminated 151 of the 202 episodes (74.8%) in total. The success rate of the ATP was not different among the three groups: 73.3% in Group A, 80.6% in Group B, and 66.7% in Group C. ATP success rate of >50% and >70% was 77.6% and 64.7% of the patients, respectively. Left ventricular ejection fraction (LVEF) was significantly higher in the patients with rather than without successful ATP therapy, and receiver operating characteristic (ROC) analysis revealed that LVEF of 23% was the optimal cut‐off value. ATP was less effective in patients taking amiodarone, but etiology of the structural heart diseases, indication of the device implantation, and all Electrocardiogram (ECG) parameters were not useful predictors for successful ATP therapy.ConclusionsATP highly terminated fast VT with wide HR ranges in patients with structural heart diseases, and should be considered as the first‐line therapy for fast VT except for patients with very low LVEF.
ECG patterns of successful permanent left bundle branch area pacing in bradycardia patients with typical bundle branch block
Authors: Li Xiaofei , Fan Xiaohan , Li Hui , Ning Xiaohui , Liang Erpeng , Ma Wentao , Wang Hao , Liu Zhimin , Yao Yan 
Published: June 2020

AbstractAimTo assess the electrocardiogram patterns of paced QRS narrowing after successful left bundle branch area pacing (LBBAP) and echocardiographic measurements in patients with bradycardia and bundle branch block (BBB).MethodsWe prospectively enrolled 55 consecutive bradycardia patients with BBB and left ventricular ejection fraction ≥40% who had attempted LBBAP. Successful LBBAP was defined as paced QRS morphology of a right BBB (RBBB) pattern in lead V1 and a recording of abruptly shortened and then constant stimulus to peak left ventricular activation time with high and low output. Pacing characteristics and echocardiographic measurements were evaluated perioperatively and at 6‐month follow‐up.ResultsThe success rate of LBBAP was 83.6% in patients with BBB, and median cumulative X‐ray dose‐area product was 100.5 µGym2 (60.0, 179.3). LBBAP was successful in 19 of 26 patients with left BBB (LBBB) (73.1%) and in 27 of 29 patients with RBBB (93.1%). The QRS duration (QRSd) was significantly shortened in patients with LBBB (QRSd 169.4 ± 22.6 to 119.6 ± 9.5 ms), and five forms of QRSd narrowing were observed in patients with RBBB with the mean QRSd shortened from 143.1 ± 16.6 ms to 119.5 ± 11.7 ms. The thresholds for narrowing of QRSd were higher in RBBB than LBBB (1.74 ± 0.36 V/0.4 ms vs 0.79 ± 0.17 V/0.4 ms, P < .001). During the 6‐month follow‐up, both left and right ventricular synchronies were improved, and narrow QRSd persisted in patients with BBB.ConclusionIn most bradycardia patients, RBBB could be completely or partially narrowed by LBBAP at different pacing models in addition to the correction of LBBB with LBBAP.
Hereditary angioedema in children and adolescents – A consensus update on therapeutic strategies for German‐speaking countries
Authors: Wahn Volker , Aberer Werner , Aygören‐Pürsün Emel , Bork Konrad , Eberl Wolfgang , Faßhauer Maria , Krüger Renate , Magerl Markus , Martinez‐Saguer Inmaculada , Späth Peter , Staubach‐Renz Petra , Weber‐Chrysochoou Christina 
Published: June 2020

AbstractBackground/MethodsAt a consensus meeting in August 2018, pediatricians and dermatologists from German‐speaking countries discussed the therapeutic strategy for the treatment of pediatric patients with type I and II hereditary angioedema due to C1 inhibitor deficiency (HAE‐C1‐INH) for Germany, Austria, and Switzerland, taking into account the current marketing approval status. HAE‐C1‐INH is a rare disease that usually presents during childhood or adolescence with intermittent episodes of potentially life‐threatening angioedema. Diagnosis as early as possible and an optimal management of the disease are important to avoid ineffective therapies and to properly treat swelling attacks. This article provides recommendations for developing appropriate treatment strategies in the management of HAE‐C1‐INH in pediatric patients in German‐speaking countries. An overview of available drugs in this age‐group is provided, together with their approval status, and study results obtained in adults and pediatric patients.Results/ConclusionCurrently, plasma‐derived C1 inhibitor concentrates have the broadest approval status and are considered the best available option for on‐demand treatment of HAE‐C1‐INH attacks and for short‐ and long‐term prophylaxis across all pediatric age‐groups in German‐speaking countries. For on‐demand treatment of children aged 2 years and older, recombinant C1‐INH and bradykinin‐receptor antagonist icatibant are alternatives. For long‐term prophylaxis in adolescents, the parenteral kallikrein inhibitor lanadelumab has recently been approved and can be recommended due to proven efficacy and safety.
Formation binning: a new method for increased temporal resolution in regional studies, applied to the Late Cretaceous dinosaur fossil record of North America
Authors: Dean Christopher D. , Chiarenza A. Alessandro , Maidment Susannah C. R. 
Published: June 2020

AbstractThe advent of palaeontological occurrence databases has allowed for detailed reconstruction and analyses of species richness through deep time. While a substantial literature has evolved ensuring that taxa are fairly counted within and between different time periods, how time itself is divided has received less attention. Stage‐level or equal‐interval age bins have frequently been used for regional and global studies in vertebrate palaeontology. However, when assessing diversity at a regional scale, these resolutions can prove inappropriate with the available data. Herein, we propose a new method of binning geological time for regional studies that intrinsically incorporates the chronostratigraphic heterogeneity of different rock formations to generate unique stratigraphic bins. We use this method to investigate the diversity dynamics of dinosaurs from the Late Cretaceous of the Western Interior of North America prior to the Cretaceous–Palaeogene mass extinction. Increased resolution through formation binning pinpoints the Maastrichtian diversity decline to between 68 and 66 Ma, coinciding with the retreat of the Western Interior Seaway. Diversity curves are shown to exhibit volatile patterns using different binning methods, supporting claims that heterogeneous biases in this time‐frame affect the pre‐extinction palaeobiological record. We also show that the apparent high endemicity of dinosaurs in the Campanian is a result of non‐contemporaneous geological units within large time bins. This study helps to illustrate the utility of high‐resolution, regional studies to supplement our understanding of factors governing global diversity in deep time and ultimately how geology is inherently tied to our understanding of past changes in species richness.
Alopecia universalis after drug reaction with eosinophilia and systemic symptoms (Dress)
Authors: Hollingsworth Parker , Paci Karina , Evans Megan , Miedema Jayson , Morrell Dean S. 
Published: June 2020

AbstractDrug reaction with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous adverse reaction characterized by a morbilliform cutaneous eruption, fever, lymphadenopathy, and multiorgan involvement. Alopecia universalis is a variant of alopecia areata characterized by complete loss of hair on the entire body. Herein, we report a case of alopecia universalis that presented after DRESS.
Harmless Effects of Sterilizing 222‐nm far‐UV Radiation on Mouse Skin and Eye Tissues
Authors: Cadet Jean 
Published: June 2020

AbstractIn this issue, Yamano et al. provide further evidence that germicidal 222‐nm far UV light has no immediate and delayed harmful effects on the skin and ocular tissue of rats. The safety of 222‐nm krypton–chlorine excimer lamps, highlighted in the commentary article, has already received relevant applications in the treatment of surgical site infections and in the control of airborne and foodborne pathogens.
Genome‐wide identification and characterization of microRNAs responding to ABA and GA in maize embryos during seed germination
Authors: Liu J. , Guo X. , Zhai T. , Shu A. , Zhao L. , Liu Z. , Zhang S. 
Published: June 2020

Abstract

MicroRNAs (miRNAs) are an important class of non‐coding small RNAs that regulate the expression of target genes through mRNA cleavage or translational inhibition. Previous studies have revealed their roles in regulating seed dormancy and germination in model plants such as Arabidopsis thaliana, rice (Oryza sativa) and maize (Zea mays). However, the miRNA response to exogenous gibberellic acid (GA) and abscisic acid (ABA) during seed germination in maize has yet to be explored.

In this study, small RNA libraries were generated and sequenced from maize embryos treated with GA, ABA or double‐distilled water as control.

A total of 247 miRNAs (104 known and 143 novel) were identified, of which 45 known and 53 novel miRNAs were differentially expressed in embryos in the different treatment groups. In total, 74 (37 up‐regulated and 37 down‐regulated) and 55 (23 up‐regulated and 32 down‐regulated) miRNAs were expressed in response to GA and to ABA, respectively, and a total of 18 known and 38 novel miRNAs displayed differential expression between the GA‐ and ABA‐treated groups. Using bioinformatics tools, we predicted the target genes of the differentially expressed miRNAs. Using GO enrichment and KEGG pathway analysis of these targets, we showed that miRNAs differentially expressed in our samples affect genes encoding proteins involved in the peroxisome, ribosome and plant hormonal signalling pathways.

Our results indicate that miRNA‐mediated gene expression influences the GA and ABA signalling pathways during seed germination.
Visualizing the Effects of Predictor Variables in Black Box Supervised Learning Models
Authors: Apley Daniel W. , Zhu Jingyu 
Published: June 2020

SummaryIn many supervised learning applications, understanding and visualizing the effects of the predictor variables on the predicted response is of paramount importance. A shortcoming of black box supervised learning models (e.g. complex trees, neural networks, boosted trees, random forests, nearest neighbours, local kernel-weighted methods and support vector regression) in this regard is their lack of interpretability or transparency. Partial dependence plots, which are the most popular approach for visualizing the effects of the predictors with black box supervised learning models, can produce erroneous results if the predictors are strongly correlated, because they require extrapolation of the response at predictor values that are far outside the multivariate envelope of the training data. As an alternative to partial dependence plots, we present a new visualization approach that we term accumulated local effects plots, which do not require this unreliable extrapolation with correlated predictors. Moreover, accumulated local effects plots are far less computationally expensive than partial dependence plots. We also provide an R package ALEPlot as supplementary material to implement our proposed method.
Tear film concentrations of topically applied 0.5% oxytetracycline ointment in normal canine eyes
Authors: Sigmund Alex B. , Ward Daniel A. , Cox Sherry K. , Hendrix Diane V. H. 
Published: June 2020

AbstractObjectiveTo determine the tear film levels of oxytetracycline in normal canine eyes after application of the ophthalmic ointment, Terramycin™ (0.5% oxytetracycline, polymyxin B sulfate), to guide appropriate treatment frequency.Animals studiedTen research beagles.ProceduresTen research beagles with confirmed normal eyes were administered 0.02 mL of Terramycin™ ophthalmic ointment onto the dorsal bulbar conjunctival surface of the right eye. Tear samples were collected via dye‐less Schirmer tear strips at 2, 4, 6, 8, and 12 hours post‐administration. The sample for each timepoint was collected on a separate day, and concentrations of oxytetracycline were determined using high‐performance liquid chromatography (HPLC).ResultsThere was a semi‐logarithmic decline in the median tear concentration of oxytetracycline. The median (2.5th and 97.5th percentiles) tear concentrations of oxytetracycline at 2, 4, 6, 8, and 12 hours were 43.5 μg/mL (11.1‐302.2 μg/mL), 28.7 μg/mL (8.04‐113.7 μg/mL), 16.1 μg/mL (4.96‐37.7 μg/mL), 9.2 μg/mL (4.52‐28.1 μg/mL), and 6.11 μg/mL (4.36‐26.7 μg/mL), respectively. Mean (±SD) drug recovery via HPLC was 88% (±7.5%).ConclusionsOphthalmic Terramycin™ achieves a substantially higher tear level than the MIC for common bacterial corneal pathogens up to 12 hours post‐administration in normal eyes. Anti‐collagenolytic tear levels were not achieved at the timepoints evaluated or with the manufacturer‐prescribed dosing frequency. HPLC can be used to analyze tear concentrations of ophthalmic ointment formulations.
THE CRISPR APPLE ON THE TREE OF KNOWLEDGE CONFERENCE HIGHLIGHTS: CRISPR IN SCIENCE, ETHICS, AND RELIGION
Authors: Gouw Arvin M. 
Published: June 2020

AbstractThe Institute on Religion in the Age of Science (IRAS) asked Ted Peters, an eminent theologian and bioethicist who was at the forefront of the cloning and stem cell debates in the past few decades, and myself, a molecular biologist, to invite scholars from various fields to brainstorm the religious and ethical implications of the CRISPR revolution. We invited keynote speakers, whose talks will be covered here, as well as other speakers and poster presentations. The conference also hosted question and answer sessions, chaplain sessions, and discussions throughout the week at the beautiful Star Island in the summer of 2019. The purpose of this paper is to highlight and sample the discussions and presentations from that conference. I will organize them into three broad topics: CRISPR in science, ethics, and religion. For readers unfamiliar with CRISPR technology, this overview can also serve as an introduction to the field, and a stepping stone for future ideas for CRISPR discussions.
BEMBA MYSTICO‐RELATIONALITY AND THE POSSIBILITY OF ARTIFICIAL GENERAL INTELLIGENCE (AGI) PARTICIPATION INIMAGO DEI
Authors: Kaunda Chammah Judex 
Published: June 2020

AbstractThis article interrogates the challenge artificial general intelligence (AGI) poses to religion and human societies, in general. More specifically, it seeks to respond to “Singularity”—when machines reach a level of intelligence that would put into question the privileged position humanity enjoys asimago Dei. Employing the Bemba notion of mystico‐relationality in dialogue with the concepts of the “created co‐creator” and Christ the Key, it argues for the possibility of AI participating inimago Dei. The findings show that imaging is a fluid, participatory activity that aims at likeness, but also social harmony. It also argues that God is the only original creator, humans are created creators, and that every aspect of visible existence, including AI, is inherently divine imaging. However, strong imaging is only attainable based on the only One and True Image—Christ, whose union of the material and the divine means that all creation can image, excluding nothing, even AI.
MENTAL FREEDOM AND FREEDOM OF THE LOVING HEART: FREE WILL AND BUDDHIST MEDITATION
Authors: Meyers Karin L. 
Published: June 2020

AbstractInBuddhism, Meditation and Free Will: A Theory of Mental Freedom, Rick Repetti explains how the dynamics of Buddhist meditation can result in a kind of metacognition and metavolitional control that exceeds what is required for free will and defeats the most powerful forms of free will skepticism. This article argues that although the Buddhist path requires and enhances the kind of mental and volitional control Repetti describes, the central dynamic of the path and meditation is better understood as a process of habituation. This not only involves the dis‐identification from mental and emotional content that Repetti discusses—and is commonly emphasized in modern presentations of mindfulness or insight (vipassanā) meditation—but also a transformation of the heart that is effected through the complementary psychological and somatic qualities associated with calm abiding (samatha) and concentration (samādhi) and emphasized in the Pali Nikāyas and commentaries.
Recreating Historical Malay Architecture with BIM Process
Authors: Mustafa Muhammad Hadi , Ali Maisarah , Has Yun Hashim Khairusy Syakirin , Mohd Suhaimi Mohamad Saifulnizam 
Published: June 2020

In South-East Asia, the Malay architecture is among the popular subject of research because of its historical importance within the region, apart from many others. To some researchers, the Malay architecture is unique because of its intangible meaning and historically rich design characters. It is difficult to be reproduced, and only limited numbers of people are acknowledged as experts. With the introduction of technology such as BIM, it is hypothesized that the gap can be minimized. The idea of this paper is to outline the process of recreating cultural architectural design using a modern process such as Building Information Modelling (BIM) platform in specific, from data collection using Terrestrial Laser Scanning (TLS) and digitalization process in Revit software. This paper employs observation approach using data from laser scanner collected from case study and content analysis technique. While normally most of the cultural architecture is undocumented, the findings of this activity are aimed to provide guideline to develop geometrical information for heritage-enthusiast in practicing their undertakings. It is hoped that more historical and cultural architecture can be recreated and appreciated for the use and inspiration of current construction industry
The Brand Image and Brand Associations of Langkawi and Phuket: A Brand Concept Map Analysis/ Imej dan Asosiasi Jenama Langkawi dan Phuket: Satu Analisis Peta Konsep Jenama
Authors: Mohd Yusof Mohd Hafiz , Mustafa Hasrina 
Published: June 2020

In the current competitive scenario of tourism industry, brand association studies are important to identify the authentic brand image of tourism destinations. This would eventually benefit the key players in the tourism industry in planning an effective tourism marketing campaign. The present study aims to analyze the brand image of Langkawi and Phuket and to identify the differences in brand associations in the tourists' memory who visited the two destinations. Incorporating Brand Concept Mapping approach, the study used preliminary survey and focus group interviews to achieve the objectives of the study. Findings indicated that Langkawi was identified as a 'Family-oriented” or “Multiproduct” Destination as reflected in its multifarious list of brand associations covering from history, natural beauty, shopping centre and recreational destination. Meanwhile, Phuket was associated as an ‘Entertainment-oriented Destination’ with its structural brand associations were linked towards entertainment and pleasure such as nightclubs. Thai girl show, brothels and nightlife.
A Novel Method of Obtaining Honing Tool Profile for Machining Gears With Profile Modifications
Authors: Batsch Michał 
Published: June 2020

Abstract
In this study, a mathematical model of the honing process for helical gears with external teeth was developed. The proposed novel method of obtaining the two-parameter envelope of a family of surfaces proved useful in simulated machining by means of a tool with a profile deviation. Based on performed simulations and industrial applications, it was found that this method can be useful in predicting the accuracy of machined gear and therefore can be used in the design process of honing tool for high precision aerospace gears. For the example provided, the average absolute prediction error of machined tooth profile was 0.28 µm.