bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-throughput detection of antibodies targeting the SARS-CoV-2 Spike in longitudinal convalescent plasma samples
Authors: Anand Sai Priya , Prévost Jérémie , Richard Jonathan , Perreault Josée , Tremblay Tony , Drouin Mathieu , Fournier Marie-Josée , Lewin Antoine , Bazin Renée , Finzi Andrés 
Published: October 2020

AbstractBackgroundThe SARS-CoV-2 virus is the cause of the ongoing coronavirus disease 2019 (COVID-19) pandemic, infecting millions of people and causing more than a million deaths. The SARS-CoV-2 Spike glycoproteins mediate viral entry and represent the main target for antibody responses. Humoral responses were shown to be important for preventing and controlling infection by coronaviruses. A promising approach to reduce the severity of COVID-19 is the transfusion of convalescent plasma. However, longitudinal studies revealed that the level of antibodies targeting the receptor-binding domain (RBD) of the SARS-CoV-2 Spike declines rapidly after the resolution of the infection.Study Design and MethodsTo extend this observation beyond the RBD domain, we performed a longitudinal analysis of the persistence of antibodies targeting the full-length SARS-CoV-2 Spike in the plasma from 15 convalescent donors. We generated a 293T cell line constitutively expressing the SARS-CoV-2 Spike and used it to develop a high-throughput flow cytometry-based assay to detect SARS-CoV-2 Spike specific antibodies in the plasma of convalescent donors.Results and ConclusionWe found that the level of antibodies targeting the full-length SARS-CoV-2 Spike declines gradually after the resolution of the infection. This decline was not related to the number of donations, but strongly correlated with the decline of RBD-specific antibodies and the number of days post-symptom onset. These findings help to better understand the decline of humoral responses against the SARS-CoV-2 Spike and provide important information on when to collect plasma after recovery from active infection for convalescent plasma transfusion.
Restructuring of genomic provinces of surface ocean plankton under climate change
Authors: Frémont Paul , Gehlen Marion , Vrac Mathieu , Leconte Jade , Delmont Tom O. , Wincker Patrick , Iudicone Daniele , Jaillon Olivier 
Published: October 2020

AbstractThe impact of climate change on diversity, functioning and biogeography of marine plankton remains a major unresolved issue. Here, niche theory is applied to plankton metagenomes of 6 size fractions, from viruses to meso-zooplankton, sampled during theTaraOceans expedition. Niches are used to derive plankton size-dependent structuring of the oceans south of 60°N inclimato-genomicprovinces characterized by signature genomes. By 2090, assuming the RCP8.5 high warming scenario, provinces would be reorganized over half of the considered ocean area and quasi-systematically displaced poleward. Particularly, tropical provinces would expand at the expense of temperate ones. Sea surface temperature is identified as the main driver of changes (50%) followed by phosphate (11%) and salinity (10%). Compositional shifts among key planktonic groups suggest impacts on the nitrogen and carbon cycles. Provinces are linked to estimates of carbon export fluxes which are projected to decrease on average by 4% in response to biogeographical restructuring.
A thematic analysis of highly retweeted early COVID-19 tweets: consensus, information, dissent and lockdown life
Authors: Thelwall Mike , Thelwall Saheeda 
Published: October 2020

PurposePublic attitudes towards COVID-19 and social distancing are critical in reducing its spread. It is therefore important to understand public reactions and information dissemination in all major forms, including on social media. This article investigates important issues reflected on Twitter in the early stages of the public reaction to COVID-19.Design/methodology/approachA thematic analysis of the most retweeted English-language tweets mentioning COVID-19 during March 10–29, 2020.FindingsThe main themes identified for the 87 qualifying tweets accounting for 14 million retweets were: lockdown life; attitude towards social restrictions; politics; safety messages; people with COVID-19; support for key workers; work; and COVID-19 facts/news.Research limitations/implicationsTwitter played many positive roles, mainly through unofficial tweets. Users shared social distancing information, helped build support for social distancing, criticised government responses, expressed support for key workers and helped each other cope with social isolation. A few popular tweets not supporting social distancing show that government messages sometimes failed.Practical implicationsPublic health campaigns in future may consider encouraging grass roots social web activity to support campaign goals. At a methodological level, analysing retweet counts emphasised politics and ignored practical implementation issues.Originality/valueThis is the first qualitative analysis of general COVID-19-related retweeting.
Moderating effects of perceived risk on the determinants–outcome nexus of e-money behaviour
Authors: Susanto Perengki , Hoque Mohammad Enamul , Hashim Nik Mohd Hazrul Nik , Shah Najeeb Ullah , Alam Mohammad Nur A. 
Published: October 2020

PurposeIn recent years, the usage rate of electronic money (e-money) has grown rapidly in many countries around the world and is becoming widely accepted in developing nations due to evolving market conditions and buying patterns. This study explores the determinants of customers' behavioural intention (BI) and actual usage behaviour (UB) of e-money service in a transition economic setting. Additionally, since there has been limited research on moderating influences, this study introduces perceived risk (PR) as a moderator, underpinned by relevant technology acceptance and behavioural theories.Design/methodology/approachThe proposed model and hypothesised variable relationships are tested using partial least squares-structural equation modelling (PLS-SEM) with survey data from 337 e-money service users in Indonesia.FindingsThe empirical results revealed that facilitating conditions (FCs), hedonic motivation (HM), price value (PV), habit (HT) and PR are important determinants of customers’ BI towards e-money and most of these variables also affect actual UB of e-money services. Performance expectancy (PE), effort expectancy (EE) and social influence (SI) emerged to be insignificant determinants. The study also uncovered that PR negatively moderates the links between EE, SI, HM, PV and BI towards e-money services. Likewise, PR has an adverse effect on the BI–actual UB relationship.Research limitations/implicationsA large portion of the sample comprised young individuals with tertiary education. In essence, the sample represents the millennial generation and they are generally characterised as responsive, innovative and technology literate. Future studies could advance the present understanding by comparing different customer backgrounds and country.Practical implicationsThe results shed light into the key factors that enhance e-money usage behaviours and have direct managerial implications with regard to brand strategy and market targeting. The findings imply that e-money service providers should take initiatives to retain users with effective and personalised marketing efforts, particularly via mobile media brand promotions.Originality/valueWhile there has been considerable discussion on how PR may impact on initial preference and adoption of e-money, existing studies seem to fall short in conceptualising and empirically examining the moderating role of PR on the determinants and outcome of e-money BI.
The Government of Jamaica (GoJ) COVID-19 pandemic stimulus response: an opportunity to regulate and formalize?
Authors: Ricketts Heather 
Published: October 2020

PurposeThe purpose of the paper is to determine whether the Government of Jamaica's COVID-19 Allocation of Resources for Employees (CARE) Stimulus Response program provides a sufficient opportunity for formalization of the informal economy.Design/methodology/approachA careful examination of the program has been conducted, specifically through reading the CARE brochure, reading the budget presentation by the Minister of Finance in which the program was introduced and details highlighted, following program updates at COVID-19 Press briefings and the Minister's Twitter account, and following related articles and programs via original and social media.FindingsThis paper suggests that any capitalizing on the opportunity to promote formalization is insufficient. Early data show increased applications for licenses and registration by informal operators, but the CARE program is only short-term, and the benefits of formalization will have to surpass those of informality to be sufficiently attractive. Other attractors must necessarily involve simplifying the process of contributing to the National Insurance Scheme; and offering unemployment insurance; along with access to finance, education and training and policymaking opportunities. COVID-19 provides the possibility of a “new deal” for the informal economy that could yield productivity gains and more inclusive development.Originality/valueThis is one of the earliest examinations of how the short-term financial support schemes implemented by the GoJ as its COVID-19 Stimulus Response has been used as an incentive to formalize the large informal economy.
Does remittance inflow stimulate electricity consumption in India? An empirical insight
Authors: Sahoo Malayaranjan , Sethi Narayan 
Published: October 2020

PurposeThe purpose of this paper is to examine whether remittance inflow stimulate electricity consumption in India with other macroeconomic variables such as FDI, trade openness and urbanization in energy demand function from 1975–2017.Design/methodology/approachWe have applied structural break and co-integration tests for stationarity and long-run relationship between the variables. The Toda–Yamamatoo causality is employed for investigation of causal relationship between the variables, and robustness of causality linkages is also tested by applying innovative accounting approach (IAA).FindingsOur empirical analysis shows there is presence of long-run relationship among the variables. We find that remittance inflows stimulate electricity consumption in India. Industrialization is positively linked with electricity demand. However, trade openness declines the electricity consumption, but urbanization increases it. Furthermore, remittances inflows cause electricity consumption.Originality/valueOn the basis of findings, we conclude that due to positive impacts of remittances inflows, trade openness and urbanization, policymakers in the Indian economy need to be careful while designing sustainable environment policy. Otherwise, any sustainable environment policy in the name of protecting green environment will hamper the growth of remittance inflows, urbanization and FDI. If this exists, it may be argued that sustainable growth in India will not be possible in the face of sustainable environment policy.
Biased assessment of ongoing admixture using STRUCTURE in the absence of reference samples
Authors: Ravagni Sara , Sanchez‐Donoso Ines , Vilà Carles 
Published: October 2020

AbstractDetection of hybridization and introgression is important in ecological research as in conservation and evolutionary biology. STRUCTURE is one of the most popular software to study introgression and allows estimating what proportion of the genome of each individual belongs to each ancestral population, even in cases where no reference sample from the ancestral nonadmixed populations is previously identified. In spite of its frequent use, some studies have indicated that ancestry estimates may not always be reliable. We simulated population data under different conditions with regard to the genetic differentiation between ancestral populations, number of loci considered, number of alleles per marker and hybridization rate, and analysed data with STRUCTURE. When reference samples were not included, the comparison of the known degree of admixture for each simulated individual and the value estimated with STRUCTURE revealed a strong underestimation of the level of introgression, classifying many admixed individuals as nonadmixed. This derives from an inaccurate estimation of the ancestral allele frequencies. When samples from the nonadmixed ancestral population were included as reference in the analyses, the bias in the estimations was reduced. The most accurate estimates were obtained when potentially admixed samples were few in relation to reference samples. Thus, whenever possible, a very large proportion of nonadmixed reference samples should be included in admixture assessments and different approaches should be combined. The misestimate of the amount of introgression can impair our understanding of the evolutionary history of species and misguide conservation efforts.
Drinking Motives as Moderators of In‐the‐Moment Drinking Risks in Response to Trauma‐Related Distress
Authors: Zaso Michelle J. , Read Jennifer P. 
Published: October 2020

BackgroundTrauma exposure and posttraumatic stress disorder (PTSD) symptomatology are linked to increased risk for problematic drinking, yet the factors that increase such risk remain largely unknown. Theoretical models suggest that affectively oriented drinking motives may be central to trauma‐related drinking. Specifically, individual‐level motivations to drink to regulate affect may be important for moderating drinking urges that occur acutely in response to trauma cues. Further, elevated distress associated with PTSD symptomatology may increase any affectively motivated, momentary drinking risks. However, research has yet to examine these dynamic affective processes. In a large experimental sample, the current study tested whether affective (i.e., coping and enhancement) drinking motives and PTSD symptomatology moderated individuals’ drinking urge in response to a trauma cue in a laboratory cue reactivity paradigm.MethodsCollege drinkers (n = 611, 53% female) were recruited and selected across levels of trauma exposure and PTSD symptomatology by a structured clinical interview. Participants were randomized to a personalized trauma or neutral cue, reporting on their urge to drink alcohol before and after cue exposure. Drinking motives were assessed at the end of the experimental session.ResultsTrauma cue associations with drinking urge were moderated by coping, but not enhancement, motives. Specifically, stronger coping motives were associated with increases in urge to drink alcohol following exposure to a trauma but not neutral cue. PTSD classification did not significantly moderate these associations.ConclusionsCoping motives may increase drinking urge immediately following exposure to trauma cues and may differentiate individuals most at risk for problematic drinking during trauma‐associated distress. Findings support momentary negative affect processes driving dynamic, immediate trauma‐related drinking risks.
Comorbid rectus abdominis diastasis is a risk factor for recurrence of umbilical hernia in Japanese patients
Authors: Nishihara Yuichi , Asami Momoko , Shimada Takehiro , Kawaguchi Yoshiki , Omoto Kenichiro 
Published: October 2020

AbstractIntroductionRectus abdominis diastasis (RAD) is characterized by thinning and widening of the linea alba and laxity of the ventral abdominal muscle. RAD, when coexistent with umbilical hernia, is considered a risk factor for hernia recurrence. We investigated the impact of comorbid RAD in patients with umbilical hernia who had undergone hernia repair.MethodsWe enrolled 30 patients who had undergone umbilical hernia repair using either a laparoscopic or anterior approach between April 2006 and May 2018. We diagnosed RAD according to preoperative CT. The outcomes of patients with umbilical hernia, the RAD group, and the non‐RAD group were compared, especially in terms of recurrence.ResultsTwenty‐five patients (83%) presented with RAD, including three patients (12%) with postoperative recurrence who were allocated to the RAD group. The median BMI in the RAD group was 27.2 kg/m2. In the RAD group, a prosthesis mesh was used in 12 patients (48%), and nonabsorbable suture material was used in four patients (16%). There was no statistically significant difference between the two groups in terms of age, hernial orifice diameter, surgical technique, or operative time.ConclusionThe rate of comorbid umbilical hernia in Japanese patients with RAD was high, as was the recurrence rate of umbilical hernia. We strongly recommend preoperative detection of RAD. We also recommend mesh‐based repair of the midline and nonabsorbable suture material to decrease the recurrence rate, irrespective of hernia size.
Endoscopic intragastric balloon therapy for 15 years in Japan: Results of nationwide surveys
Authors: Ohta Masayuki , Maekawa Satoshi , Imazu Hiroki , Hatao Fumihiko , Okumura Yoshiaki , Kiyonaga Hidetoshi , Sawada Yukio , Inamori Masahiko , Seto Yasuyuki , Masaki Takayuki , Kakuma Tetsuya , Kasama Kazunori , Inomata Masafumi , Kitagawa Yuko , Kaminishi Michio , Kitano Seigo 
Published: October 2020

AbstractIntroductionEndoscopic intragastric balloon (IGB) placement has been performed in Japan since 2004. The nationwide surveys were repeatedly carried out to confirm the effectiveness and safety of IGB in Japan. We herein present the accumulated results.MethodsTwenty‐six Japanese endoscopists personally imported products of the BioEnterics Intragastric Balloon (BIB)/Orbera system after completing the training courses in Japan. Mail surveys were posted to them every 2 years from 2010. This study included the accumulated data of the six surveys, and excluded data from non‐Japanese patients and the Orbera365 data.ResultsBetween 2004 and 2019, 399 obese Japanese patients underwent IGB treatment using the BIB/Orbera system. The incidence rates of early removal of IGB within 1 week and complications due to IGB were 4.8% and 6.1%, respectively. The average percent excess weight loss (%EWL) and percent total weight loss (%TWL) at IGB removal were 46.6% and 11.5%, and successful weight loss, defined as %EWL ≥ 25% or %TWL ≥ 10%, was achieved in 65.6% or 54.5% of the patients, respectively. Multivariate analyses revealed that older age and larger saline filling volume were independent predictors of successful weight loss. At 1 year after IGB removal, successful weight loss defined by the %EWL and %TWL was maintained in 44.7% and 34.1% of the patients, respectively.ConclusionIGB therapy using the BIB/Orbera system has been safely and effectively performed in Japan. The successful weight loss may be associated with older age and larger saline filling volume.
A dose‐dense short‐term therapy for human immunodeficiency virus/acquired immunodeficiency syndrome patients with high‐risk Burkitt lymphoma or high‐grade B‐cell lymphoma: safety and efficacy results of the “CARMEN” phase II trial
Authors: Ferreri Andrés J. M. , Cattaneo Chiara , Lleshi Arben , Verga Luisa , Allione Bernardino , Facchetti Fabio , Ponzoni Maurilio , Foppoli Marco , Ferrari Daris , Rigacci Luigi , Pecciarini Lorenza , Donadoni Giovanni , Fumagalli Luca , Sassone Marianna , Calimeri Teresa , Rossi Giuseppe , Spina Michele , Re Alessandro 
Published: October 2020

SummaryA few prospective trials in HIV‐positive patients with Burkitt lymphoma (BL) or high‐grade B‐cell lymphoma (HGBL) have been reported. Investigated therapies have shown good efficacy but relevant safety problems, with high rates of interruptions, severe mucositis, septic complications, and fungal infections. Here, we report the results of a multicentre phase II trial addressing a new dose‐dense, short‐term therapy aimed at maintaining efficacy and improving tolerability. The experimental programme included a 36‐day polychemotherapy induction followed by high‐dose cytarabine‐based consolidation and response‐tailored BEAM (carmustine, etoposide, cyatarabine, and melphalan)‐ conditioned autologous stem cell transplantation (ASCT). This therapy would be considered active if ≥11 complete remissions (CR) after induction (primary endpoint) were recorded among 20 assessable patients. HIV‐positive adults (median age 42, range 26–58; 16 males) with untreated BL (n = 16), HGBL (n = 3) or double‐hit lymphoma (n = 1) were enrolled. All patients had high‐risk features, with meningeal and bone marrow infiltration in five and nine patients respectively. The experimental programme was safe and active in a multicentre setting, with only two episodes of grade 4 non‐haematological toxicity (hepatotoxicity and mucositis), and no cases of systemic fungal infections; two patients died of toxicity (bacterial infections). Response after induction (median duration: 47 days; interquartile range 41–54), was complete in 13 patients and partial in five [overall response rate = 90%; 95% confidence interval (CI) = 77–100]. All responders received consolidation, and five required autologous stem cell transplant. At a median follow‐up of 55 (41–89) months, 14 patients are relapse‐free and 15 are alive, with a five‐year progression‐free survival and an overall survival of 70% (95% CI = 60–80%) and 75% (95% CI = 66–84) respectively. No patient with cerebrospinal fluid (CSF)/meningeal lymphoma experienced central nervous system recurrence. With respect to previously reported regimens, this programme was delivered in a shorter period, and achieved the main goal of maintaining efficacy and improving tolerability.
Hero or Villain? A Cohort and Generational Analysis of How Youth Attitudes Towards Unions Have Changed over Time
Authors: Aleks Rachel , Saksida Tina , Wolf Aaron S. 
Published: October 2020

AbstractOur study examines youth attitudes towards unions over a 40‐year period to try and understand whether today's young workers might be the ‘hero’ or the ‘villain’ in the tale of declining union membership rates in the United States. Using nationally representative time‐lag data from high‐school seniors (N= 104,742) spanning 1976–2015, we conducted time trend, birth cohort and generational analyses to provide an ‘apples to apples’ comparison of how youth have felt about unions at different points in time. We found that contemporary youth (or Millennials) hold similar union attitudes to those who came before them, though what predicts those attitudes has changed over time. Strikingly, we also found that the proportion of young people who hold no opinion about unions has more than doubled over the period under study, steadily rising from 14 per cent in 1976 to 33 per cent in 2015. This sizeable proportion of ‘agnostic’ youth should be alarming to unions, yet it also provides them with opportunities to shape youth attitudes through targeted outreach efforts.
Beyond the Organic Intellectual: Politics and Contestation in the Planning Practice
Authors: Stefanelli Alice 
Published: October 2020

AbstractCritical scholarship often presents technical experts such as architects and urbanists as unidimensional “organic intellectuals” in the Gramscian sense. Drawing from ethnographic fieldwork conducted among architects‐turned‐campaigners in Lebanon, this article argues that this portrayal of experts is partial, and inadequate to represent and make sense of the composite coalitions that animate contemporary urban politics worldwide. This will be clarified by a close examination of the Hakmeh Axis Campaign, where architects and urbanists have initiated a vigorous civic campaign to oppose the construction of a motorway bridge through a historical neighborhood in Beirut. By exploring the politics ofplanners—rather than that ofplanning—the article will show the alignment between expertise and authorities to be a matter of political affiliation rather than natural necessity.