bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Frequently Does out-of Hospital Sudden Unexpected Infants Death Represent the Sudden Infant Death Syndrome?
Authors: Nisevich Lika L. , Krieger Oleg V. , Selyutina Natalia S. , Bernikov Stanislav Y. , Konopleva Tatyana N. , Nikishtsev Igor N. , Pavlova Marina S. 
Published: January 2020

Background.19.6 % of all fatal cases among Russian children who died in the first year of life are registered out-of hospital, and they are usually sudden. Out-of-hospital sudden unexpected infant death (OSUID) could be confused with sudden infant death syndrome (SIDS) followed by the wide variation in the diagnostic indicators of the syndrome.The aim of the studyis to reveal the pathological changes in the tissues and organs of 420 cases of OSUID (group 1) compared with 350 cases of death in the hospital (group 2), to estimate the conformity of the final diagnoses and to identify cases of OSUID, which were SIDS.Methods.From 2009 to 2016 pathoanatomical and virological study of the organs of 420 cases of OSUID (group 1) and 350 babies who died in a hospital were carried out.Results.It was established that the age of infants of the 1st group at the time of death in 71 % of cases corresponded to the age of SIDS. In terms of gestational age and body weight at birth babies of the 1st group turned out to be much more prosperous. Signs of rapid onset of death in this group: plethora of internal organs (83.3 %) and petechial hemorrhages (75.5 %) were present significantly more often than in the 2nd. In the 1st group, predominantly light acute respiratory viral infections (ARVI) with minimal pathologic signs and pneumonia were diagnosed, but pneumonia in 33.3 % not detected at autopsy. Purulent tracheobronchitis (0 and 21.4 %), bacterial pneumonia (6.3 and 26.3 %), a large area of lung damage (3.8 and 56.1 %) were detected much less frequently in the 1st group. In 38 % of the 1st group, pneumonia was the only cause of death, and in no case in the 2nd. Pathology of the cardiovascular system (55.2 and 87.7 %), central nervous system (58.6 and 90.9 %);urogenital system (34.8 and 62.9), inflammation of the membranes and brain tissue (21.9 and 70.0 %), signs of past or current intrauterine viral infection (29.5 and 64.0 %) in the 1st group was diagnosed much less frequently than in the 2nd, but congenital syphilis, HIV infection and hepatitis C — 3 times more often (12.9 and 3.7 %). The more frequent pathology of the adrenal glands in the 1st group (66.7 and 34 %) could cause inadequate responses to minimal exposure to external factors, including mild acute respiratory viral infections. The diagnosis of SIDS was made in 3 cases and in 3 more it was questionable. However, the presence of multisystemic pathology excludes the diagnosis of SIDS. The diagnosis of SIDS could be established in 30 cases in cases of slight ARVI without intoxication, shock liver or disseminated intravascular coagulation syndrome.Conclusion.The most cases of sudden death occurred in not obvious life-threatening conditions in socially disadvantaged families in the absence of adequate observation, diagnosis and treatment.
“Meu corpo foi reconhecido pelo estado”: as controvérsias em torno da desjudicialização do direito à identidade
Authors: Maia Gabriela Felten da 
Published: January 2020

O contexto brasileiro é marcado por uma lacuna legislativa para o acesso às retificações de registro civil para pessoas trans. A decisão do Supremo Tribunal Federal, em março de 2018, trouxe uma nova possibilidade diante da ausência de marco regulatório nacional para o processo de retificação de registro civil. Essa decisão modifica o cenário com a retirada da tutela jurídica e médica, possibilitando o acesso a uma gama mais ampla de sujeitos que desejam retificar, mas não necessariamente passar por cirurgia ou entrevistas diagnósticas para obter um laudo. Com isso, entende-se que se trata de um avanço no reconhecimento estatal da diversidade de gênero. Nesse sentido, o objetivo desse trabalho é apresentar algumas questões iniciais que emergem do trabalho de campo de doutorado a respeito da transformação no processo de regulação do direito à identidade. Procura-se refletir se desjudialização implica em desburocratização.
Palavras-chave: Pessoas Trans; Direito à Identidade; Desjudicialização.
Robot-assisted radical cystectomy with intracorporeal orthotopic cystoplasty
Authors: Guliev B. G. , Komyakov B. K. , Bolokotov R. R. 
Published: January 2020

Background. Radical cystectomy uses laparoscopic and robotic approaches along with the open ones.Objective: to study immediate results of robot-assisted radical cystectomy with intracorporeal orthotopic cystoplasty.Materials and methods. Robot-assisted radical cystectomy with intracorporeal orthotopic cystoplasty was performed in 15 patients (13 male, 2 female), aged 64–76 years. Fourteen patients had bladder cancer, 1 female – a postradiation bladder fistula and microcystis. T2 stage was detected in 8 (57.1 %) patients, T3 – in 6 (42.9 %). After the operation we evaluated operation time, blood loss volume, hospital stay, functional and oncological results.Results. Average operation time was 380 (320–560) minutes, blood loss volume – 80–200 ml, blood transfusion was not performed. Early complications (up to 30 days) were observed in 7 patients (46.7 %), late ones (90‑days) – in 6 (40.0 %). There were no cases of intestinal obstruction. Patients with ureteral-intestinal (n = 2) and reservoir-urethral (n = 1) anastomosis failure underwent percutaneous renal drainage. One patient died of acute myocardial infarction. Daytime continence was 80.0 %, nocturnal – 53.3 %. One patient died of disease progression within 7.6 observation months.Conclusion. Robot-assisted radical cystectomy with intracorporeal urine diversion is a modern and minimally invasive method for patients with muscle-invasive bladder cancer. More experience in this field will allow to reduce surgery time and number of complications.
Pancreatic metastases from renal cancer: comparing surgery and pharmacotherapy efficacy
Authors: Kotelnikov A. G. , Kriger A. G. , Podluzhny D. V. , Proskuryakov I. S. , Galkin G. V. , Patyutko Yu. I. , Fainstein I. A. 
Published: January 2020

Background. Today, targeted therapy is a standard treatment in advanced renal cell carcinoma, while the surgical method plays the role of a possible approach in a select category of patients with solitary and single metastases.The study objective to compare the effectiveness of two alternative treatment approaches: the surgical method and modern pharmacotherapy in achieving long-term overall survival of patients with pancreatic metastases of renal cell carcinoma.Materials and methods. A retrospective two-center study was conducted. The cohort of surgical treatment included patients (n = 56) who underwent surgery for pancreatic metastases from renal cell carcinoma at the N.N. Blokhin National Medical Research Center of Oncology and A.V. Vishnevsky National Medical Research Center of Surgery in the period from 1990 to 2019. Operations were performed for all types of pancreatic lesions: synchronous/metachronous, solitary/single and multiple, isolated/combined with lesions of other organs. Postoperative mortality rate was 5 % (3 patients). The pharmacotherapy cohort (n = 28) included patients with potentially resectable pancreatic metastases from clear cell renal cell carcinoma who underwent targeted therapy. Survival was assessed using the Kaplan–Mayer method. The Mantel–Cox test was used to test null hypothesis.Results. The 5-year overall survival rate was 68 % in the surgery group compared to 35 % for the pharmacotherapy group. Median overall survival for surgical and non-surgical patients was 82 months and 43 months, respectively (p = 0.01). The advantage of the surgical method was also found in a subgroup survival analysis of patients with extrapancreatic disease (p = 0.037). In this case, the 5-year overall survival rate was 66 % in the surgery subgroup (n = 25) compared to 35 % for the pharmacotherapy subgroup (n = 24). Conclusion. Radical surgical treatment in comparison with modern pharmacotherapy allows to achieve significantly higher rates of overall survival in patients with pancreatic metastases of renal cell carcinoma and can be considered as a priority.
Para além da Oferta de Unidades Curriculares: Uma Possibilidade Inclusiva para Estudantes Aspies por meio de Plataformas Virtuais
Authors: Moreira Jonathan Rosa , Barros Everson da Silva , Ribeiro Jefferson Bruno Pereira 
Published: January 2020

As instituições de educação superior ofertam as unidades curriculares por semestre em função do quantitativo de estudantes e de sua infraestrutura física. Quando o enfoque está nas instituições privadas, é razoável que esse controle seja ainda mais persistente e com processos definidos porque afeta diretamente sua sustentabilidade. Considerando as unidades curriculares que utilizam salas de aula convencionais, a quantidade de estudantes alocados por turma é feita sobre o quantitativo convencionado, e não necessariamente pelo perfil dos estudantes. No processo de ensino e aprendizagem, os professores precisam planejar sua organização didático-pedagógica em função do perfil e da pluralidade diagnosticada na turma. Há, portanto, uma dualidade de processos acadêmicos, cada um com sua importância. Por um lado, há de se garantir a situação financeira da instituição. Por outro lado, há de primar pela qualidade do processo de ensino e aprendizagem, considerando a diversidade e os diferentes estilos de aprendizagem. O objetivo deste estudo foi apresentar uma proposta de itinerário formativo, considerando as particularidades do caso de um estudante acometido por síndrome de Asperger no curso de graduação da Faculdade Projeção de Ceilândia, Distrito Federal. Para tanto, optou-se por uma abordagem mista, do tipo documental e descritivo, com cinco etapas definidas para a construção de um itinerário formativo com base na tipologia de conteúdos, taxonomia de Bloom e aprendizagem adaptativa, mediado por ambiente virtual de aprendizagem. Uma estratégia metodológica mediada por educação a distância pode ser viável para mitigar as limitações e dificuldades características da síndrome de Asperger.
Palavras-chave: Oferta Acadêmica. Educação Inclusiva. Síndrome de Asperger.
Popularyzacja języka i kultury rosyjskiej wśród dzieci. Fenomen serialu animowanego Masza i Niedźwiedź
Authors: Olechno-Wasiluk Joanna 
Published: January 2020

W niniejszym artykule autorka koncentruje się na możliwościach wykorzystania serialu animowanego Masza i Niedźwiedź w nauczaniu języka rosyjskiego dzieci w wieku przedszkolnym i wczesnoszkolnym. Zwraca uwagę na bogactwo elementów kultury rosyjskiej zawartych w serialu i przekazywanych widzowi „przy okazji” narracji. Autorka dokonuje analizy stereotypów ulokowanych w animacji, szczególnie tych o treści poznawczej, tj. związanych z dniem powszednim Rosjan, ich zainteresowaniami, tradycjami, ubiorem. Publikacja niniejsza oparta jest na doświadczeniach autorki z realizacji własnego projektu pod hasłem: „Zrozumieć Maszę. Wesoło, kolorowo i ciekawie o języku i kulturze Rosji”. Zakłada on popularyzację języka i kultury rosyjskiej wśród dzieci oraz przygotowanie ich do uczestnictwa w dialogu międzykulturowym.
Strategic Analysis of Turbine Manufacturing Development in Achieving Required Local Content
Authors: Sitompul Rislima F. 
Published: January 2020

The government of Indonesia has set up an electricity development program of 35,000 Mega Watt (MW) to provide adequate electricity infrastructure so that the 100% electrification ratio can be achieved. The construction of the development of power infrastructure has implications for the demand for reliable electrical components, which supports upstream to downstream industries. The turbine is one of the major components in electricity infrastructure which requires the supply of mechanical energy as the driving force. Despite its market potential, the turbine is a relatively high imported component, and this indicates the importance of fostering the development of turbine technology in Indonesia. The main objective of this study is to examine the capability of national turbine industries and research institutions in formulating policy recommendations to increase the use of the local content, called Tingkat Kemampuan Dalam Negeri (TKDN), in turbine manufacturing industries following the provisions stipulated in the Ministerial Decree No.54/M-IND/PER/03/2012 on Guidelines for Use of Products of State for Infrastructure Development in Electricity. This study applies SWOT and Balanced Scorecard, focusing on the analysis of capabilities of the turbine industry and identifying the mastery of turbine technology by various research and development institutions in Indonesia. The result of the study shows that the degree of BSC performance level in implementing the TKDN improvement strategy in the turbine industry is considered as less successful, therefore, short-term and long-term policy recommendation needs to be implemented to expedite the increase of TKDN.
Influence of Acoustic Waves on the Shelf Life Quality of White Oyster Mushroom (Pleurotus Florida)
Authors: Ceejay O Paclibare , Lavarias Jeffrey A. , Tuates Jr Andres M. , Somera Carolyn Grace G. , G. Peneyra Ruel 
Published: January 2020

Mushrooms are seasonal and highly perishable crops and contain about 90% (w.b) moisture. The moisture content of fresh mushrooms is 70 - 95% (w.b), depending upon the harvest time and environmental conditions, while that of dried mushrooms is close to 10% (w.b). Due to their high moisture content, they cannot be stored for more than 24 hours at ambient conditions. Hence, they need to be preserved by some methods. Moisture transportation and distribution in products are key factors for the development of the product quality. To control quality development, an understanding of the moisture content at a certain time of the product is required. The objective of the study was to extend the shelf life of fresh harvest of White oyster mushroom without compromising the quality by applying the acoustic wave with various exposure time. White oyster mushroom samples were exposed to acoustic waves (1kHz, 100 dB) inside a soundproof chamber at three levels of exposure time (1, 2, 3) hours. Subsequently, white oyster mushrooms sample stored in a refrigerator at 10 oC. The effects of acoustic waves application were determined by measuring the surface color, flesh firmness, and shelf-life extension every other day at cold storage. Results of the study indicated that white oyster mushroom samples exposed to acoustic waves for 2 hours exhibited the slowest to effect change in surface color for 13 days compared to 1 hour and 3 hours of exposure time at 11 and 12 days, respectively. Moreover, flesh firmness of white oyster mushroom samples exposed to acoustic waves for 2 hours was proved to exhibits the slowest to effect change for 13 days compared to 1 hour and 3 hours of exposure time at 11 and 12 days, respectively. The acoustic waves have a potential benefit of extending the shelf life of white oyster mushroom up to 13 days at 10 oC without altering the quality.
Evaluating Food Waste Handling Using Trios Monitoring System on Soy Industry in Bali, Indonesia
Authors: Irianto I Ketut , Arygunartha Gede Yohanes 
Published: January 2020

The purpose of this paper is to analyze a series of operational systems for biofilter technology. The object of research is an area of Wastewater Treatment in the food industry Denpasar, Bali. The Trios System Monitoring Method can be analyzed in three stages of the process of pre-treatment, treatment, stabilization, and three treatments. Biology analyzes settings (giving oxygen, feeding the number of food microorganisms F/M/ ratio, speed of waste flow). The analysis shows that biofilter technology is a technology that uses physical and biological treatment without using chemicals. Physical treatment is carried out by filtration, flotation, sedimentation. Biological treatment is carried out by regulating oxygen delivery with aeration period of 24 hours/day, microorganism feeding F/Mg/ BOD/MLSS/day ratio 0.05-0.2 with 100% proven waste flow BOD decreases by 80% pre-stage treatment. The wastewater is forwarded to the biofilter pond and given physical treatment, biological, and tricking filter in speed regulation, treatment process stage, liquid waste originating from conventional ponds is inserted into the aeration pond with aeration period of 6.0-9.0/hour. Feeding microorganisms F/Mg/BOD/day/MLSS ratio 0.2-0.5 with the waste flow 50%, BOD decreased by 85%. Feeding microorganisms F/Mg/BOD/day/MLSS ratio 0.2 - 0.5 oxygen administration with aeration period of 6.0-9.0/hour, BOD decreased by 85-90%.
11-amino acid peptide imitating the structure of erythropoietin α-helix b improves endothelial function, but stimulates thrombosis in rats.
Authors: Korokin M. V. , Soldatov V. O. , Tietze A. A. , Golubev M. V. , Belykh A. E. , Kubekina M. V. , Puchenkova O. A. , Denisyuk T. A. , Gureyev V. V. , Pokrovskaya T. G. , Gudyrev O. S. , Zhuchenko M. A. , Zatolokina M. A. , Pokrovskiy M. V. 
Published: January 2020

The aim of the study was to test whether P-αB can be positioned as a preventing and treating agent for cardiovascular diseases.Materials and methods. The study was performed on sexually mature male Wistar rats. Endothelial dysfunction was modulated by a 7-days intraperitoneal administration of L-NAME at the dose of 2.5 mg/100 g. P-αB, or erythropoietin (EPO), was used for therapy at the dose of 2.5 µg/100 g × 3 times for 7 days, the total dose was 7.5 µg/100 g. The function of endothelium was estimated by an endothelium-dependent and endothelium-independent vasodilation. In addition, a histological assessment of the abdominal aortic wall state and the analysis of eNos, Tnf and Il-1β genes expression were performed. To estimate prothrombotic properties, P-αB and EPO were administered, at the doses of 2.5 and 5 µg/100 g (3 times a day for 7 days, the total doses were 7.5 µg/100 g and 15 µg/100 g, respectively) and on the 8th day, the time of ferric (III) chloride-induced carotid artery thrombosis was estimated.Results. Theresults of the functional tests for endothelium-dependent and endothelium-independent vasodilatation, as well as the histological picture of the aorta have evidenced that P-αB and EPO do not affect L-NAME-induced hypertension but improve the endothelium function. At the same time, P-αB shows a significantly higher endothelial-protective activity, reducing the coefficient of endothelial dysfunction from 5.1±0.15 to 2.72±0.12. In addition, P-αB has significantly increased the expression of eNos and reduced the expression level of Tnf and Il-1β mRNA genes. Carrying out Ferric (III) chloride-induced carotid artery thrombosis has revealed that P-αB (5 µg/100 g × 3 times a day for 7 days, total dose was 15 µg/100 g) has a lower but statistically significant prothrombotic activity than EPO.Conclusion. P-αB can be positioned as an atheroprotector because of its ability to prevent the death of endothelial cells, as well as to reduce remodeling and proinflammatory activation of the vascular wall. However, the prothrombotic properties of P-αB limit its use as a preventing and treating agent for atherosclerosis-associated diseases.
Structural transformations of thermal burn wounds in rats under the influence of Semax and Selank neuropeptides
Authors: Azhikova A. K. , Feldman B. V. , Andreeva A. A. , Teply D. D. , Samotrueva M. A. , Myasoedov N. F. 
Published: January 2020

The morphological features of the skin of rats under the stress exposure, such as burn injury and against the background of the correction by the drugs of the peptide structure, have been studied.The aim of the study was to investigate the regulatory effect of the neuropeptide drugs Semax (Met-Glu-His-Phe-Pro-Gly-Pro) and Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) under the conditions of thermal burn exposure.Materials and methods. The object of the study was integumentary tissues (skin, subcutaneous tissue) of laboratory non-linear male rats (n = 36) excised from the thermal injury zone. A thermal burn of the skin had been caused by the application of a copper object in the interscapular in the interscapular dorsal area. Starting from the first day after the injury, neuropeptide drugs Semax (Met-Glu-His-Phe-ProGly-Pro) and Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) had been administered intraperitoneally at the doses of 100 μg/kg daily during the entire period of the experiment. To assess the condition of the skin tissues, histological sections 5–6 μm thick were prepareв, stained afterwards with hematoxylin and eosin. The consistency of the systemic effect of the neuropeptide drugs was estimated by a change in some indicators of the immune system.Results. The thermal exposure led to the development of significant degenerative and dystrophic changes in the skin. The recovery of the burn wounds on rats’ skins proceeded according to the type of the delayed partial reparative regeneration, accompanied by destructive phenomena and the formation of the scar tissue.Under the influence of the drugs based on the regulatory peptides of Semax (Met-Glu-His-Phe-Pro-Gly-Pro) and Selank (Thr-Lys-Pro-Arg-ProGly-Pro), the recovery of burn wounds in rats proceeded more intensively, compared with the animals from the group without any correction. This fact was confirmed by the earlier signs of the beginning of the reparative skin regeneration: the restriction of destructive processes within the epidermis and dermis, the absence of purulent-necrotic complications, the initial phases of granulation and epithelization, an early scab rejection and a partial closure of the defect.Conclusion. The use of the neuropeptide drugs Semax and Selank as systemic remedies for the correction of wound skin defects in experimental animals proves their polypotent effectiveness, expands the therapeutic possibilities and opens up new prospects for their use.
THE USE OF KINSHIP ANALYSIS ON PATERNITY TESTING THROUGH CODIS STR LOCI ‘CSF1PO’ AND ‘THO1’
Authors: Putri Dwi Fitrianti Arieza , Yudianto Ahmad 
Published: January 2020

Introduction: Paternity tests compare a child’s DNA pattern with the possible father to examine the DNA heritage in ensuring kinship. If there is no information from the father and mother or the child that can be used as a comparison in the forensic DNA examination process (paternity test), there must be a comparison from a close relative as an alternative to obtain the forensic DNA examination. This experiment’s purpose is to analyze the use of kinship analysis in forensic identification especially in a paternity test. Methods: This is a descriptive experiment using a cross-sectional design through locus analysis of DNA forensic examination in paternity test using the kinship analysis through STR CODIS loci: CSF1PO and THO1. The variables of this experiment were ‘locus’ as the independent variable and ‘allele number’ as the dependent variable. This experiment conducted a paternity tests to 8 samples in which the subjects were siblings; the test was administered on the CSF1PO and TH01 loci. Results: This experiment displayed similar allele numbers on the same locus, both in 50% and 100% allele numbers; the research showed similarity in allele numbers of both siblings of which ¼ were inherited from the parents (for 50% allele number similarity), and ½ were inherited from the parents (for 100% allele number similarity). Conclusion: This proves that a paternity test using siblings as the closest kin (kinship analysis) can be used as an alternative if no comparison is obtained from both the parents.