bluuebunny/crossref_metadata_2025_split huggingface dataset:
An explanatory model of factors enabling sustainability of let’s talk in an adult mental health service: a participatory case study
Authors: Allchin Becca , O’Hanlon Brendan , Weimand Bente M. , Boyer Fran , Cripps Georgia , Gill Lisa , Paisley Brooke , Pietsch Sian , Wynne Brad , Goodyear Melinda 
Published: July 2020

Abstract
Background
While effective interventions have been developed to support families where a parent has a mental illness in Adult Mental Health Services, embedding and sustaining them is challenging resulting in families not having access to support. This study developed an explanatory model of influencers that had enabled sustainability of the Let’s Talk intervention in one service.

Methods
A participatory case study was used to build an explanatory model of sustainability at the service using theoretical frameworks. Qualitative and quantitative data was collected about practitioner’s practice and the organisation’s implementation process and capacity to support practice. A local research group worked with the researcher using a transforming data approach through description, analysis and interpretation.

Results
Influencers were grouped into four major categories: (1) External social, political and financial context, (2) Resources, (3) Prior organisational capacity and (4) Sustainability Factors. The last category, Sustainability factors, was divided into three subcategories: (4.1)Practitioner (4.2) Organisation and (4.3) Parent-Client. These categories form part of an explanatory model for the key influencers of continued practitioner practice and organisational capacity to support practice.

Conclusions and implications for practice
In this case study, the pre-existing organisational context along with practitioner, organisation and parent-client factors operated together to influence sustainability. The results suggest that sustainability is more likely to be supported by both linking Let’s Talk to existing organisational identity, capacity, structures and relationships and by supporting mutual adaptations to improve the fit. Additionally, by understanding that setbacks are common and ongoing adjustments are needed, implementers are able to have realistic expectations of sustainability.
A single, shared origin for all three coronary arteries from the right coronary cusp: a case report
Authors: Nesheiwat Zeid , Eid Joseph , Soni Ronak , Harnish Paul , Sabbagh Ebrahim , Eltahawy Ehab 
Published: July 2020

Abstract
Background
Anomalous coronary arteries occur in less than 1% of the population and have been implicated in sudden cardiac and exercise-related death. The most common variant involves the left circumflex artery arising from a separate ostium than the left coronary artery. This case demonstrates a rare variation in which all three coronary arteries arise from a shared, single, ostium originating from the right coronary cusp.

Case presentation
We report the case of a 63-year-old Caucasian man with a history of myocardial infarction, congestive heart failure, and atrial fibrillation who presented for syncope. Inpatient ischemic workup, including coronary angiography, demonstrated a rare coronary anomaly which included all three coronary arteries arising from a shared, single, ostium originating from the right coronary cusp. Our patient was treated conservatively with an option for coronary bypass if symptomatic.

Conclusion
Surgical management is indicated in high-risk patients, but the optimal management for a nonmalignant, shared origin for all three coronary arteries has not been explored in detail.
Putative anti-inflammatory, antioxidant, and anti-apoptotic roles of the natural tissue guardian methyl palmitate against isoproterenol-induced myocardial injury in rats
Authors: Hamed Ahmed B. , Mantawy Eman M. , El-Bakly Wesam M. , Abdel-Mottaleb Yousra , Azab Samar S. 
Published: July 2020

Abstract
Background
Myocardial injury is considered as a worldwide main cause of morbidity and mortality. The present study aimed to investigate the probable cardioprotective activity of the naturally occurring endogenous fatty acid ester methyl palmitate (MP) against isoproterenol (ISO)-induced myocardial injury in rats and the possible underlying molecular mechanisms. The study was carried out in two consecutive sets of experiments; the first set screened the cardioprotective dose of MP in ISO-intoxicated rats. In the second set, forty male Sprague Dawley rats received either MP (150 mg/kg, p.o) three times/week for 2 weeks and/or 2 consecutive doses of ISO separated by 24 h (85 mg/kg, s.c) on the 13th and 14th days. Different cardiotoxicity and oxidative stress markers were assessed. Furthermore, endothelial nitric oxide synthase (eNOS) levels were determined. For detection of apoptosis, Bax, Bcl-2, and caspase 3 were estimated. To assess inflammation, toll-like receptor 4 (TLR-4) and tumor necrosis factor-alpha (TNF-α) were measured using ELISA. Meanwhile, nuclear factor kappa B (NF-kB) and cyclooxygenase-2 (COX-2) were detected immunohistochemically.

Results
Pretreatment with MP significantly ameliorated the cardiotoxicity and oxidative stress markers. It also markedly elevated eNOS content, decreased apoptotic marker expression, and mitigated TLR-4 activation and other inflammatory markers. Electrocardiography and histopathological examination also confirmed the cardioprotective effect of MP.

Conclusion
The findings of this study indicated that MP possesses a potent cardioprotective activity against ISO-induced myocardial injury through its significant antioxidant, anti-apoptotic, anti-inflammatory, and vasodilatation activities.

Graphical abstract
A Novel Approach to Dilation of Complete Colorectal Anastomotic Stricture Using Transillumination
Authors: Nasir Umair M. , Rodgers Brandon , Choi Catherine , Panchal Dayna , Salimi Qasim , Ahlawat Sushil 
Published: July 2020

ABSTRACT
Colorectal anastomotic strictures are a well-known complication of low anterior resection. Depending on their location, strictures are amendable to different forms of endoscopic intervention. However, all endoscopic interventions are contingent on passing a guidewire across the anastomotic stricture. We present the case of a patient with a complete anastomotic stricture that could not be traversed by conventional endoscopy and the unique method by which a lumen was created in the anastomotic strictures that allowed for a guidewire to be passed across.
Gradient estimate of a variable power for nonlinear elliptic equations with Orlicz growth
Authors: Liang Shuang , Zheng Shenzhou 
Published: July 2020

Abstract
In this paper, we prove a global Calderón-Zygmund type estimate in the framework of Lorentz spaces for a variable power of the gradients to the zero-Dirichlet problem of general nonlinear elliptic equations with the nonlinearities satisfying Orlicz growth. It is mainly assumed that the variable exponents p(x) satisfy the log-Hölder continuity, while the nonlinearity and underlying domain (A, Ω) is (δ, R
0)-vanishing in x ∈ Ω.
Protein Interactions of the Mechanosensory Proteins Wsc2 and Wsc3 for Stress Resistance in Saccharomyces cerevisiae
Authors: Vélez-Segarra Vladimir , González-Crespo Sahily , Santiago-Cartagena Ednalise , Vázquez-Quiñones Luis E , Martínez-Matías Nelson , Otero Yamirelis , Zayas Julián J , Siaca Rafael , del Rosario Jeanmadi , Mejías Inoushka , Aponte José J , Collazo Noelani C , Lasso Francisco J , Snider Jamie , Jessulat Matthew , Aoki Hiroyuki , Rymond Brian C , Babu Mohan , Stagljar Igor , Rodríguez-Medina José R 
Published: July 2020

Abstract
Antifungal drug discovery and design is very challenging because of the considerable similarities in genetic features and metabolic pathways between fungi and humans. However, cell wall composition represents a notable point of divergence. Therefore, a research strategy was designed to improve our understanding of the mechanisms for maintaining fungal cell wall integrity, and to identify potential targets for new drugs that modulate the underlying protein-protein interactions in Saccharomyces cerevisiae. This study defines roles for Wsc2p and Wsc3p and their interacting protein partners in the cell wall integrity signaling and cell survival mechanisms that respond to treatments with fluconazole and hydrogen peroxide. By combined genetic and biochemical approaches, we report the discovery of 12 novel protein interactors of Wsc2p and Wsc3p. Of these, Wsc2p interacting partners Gtt1p and Yck2p, have opposing roles in the resistance and sensitivity to fluconazole treatments respectively. The interaction of Wsc2p with Ras2p was confirmed by iMYTH and IP-MS approaches and is shown to play a dominant role in response to oxidative stress induced by hydrogen peroxide. Consistent with an earlier study, Ras2p was also identified as an interacting partner of Wsc1p and Mid2p cell wall integrity signaling proteins. Collectively, this study expands the interaction networks of the mechanosensory proteins of the Cell Wall Integrity pathway.
Review: The risk of contracting anthrax from spore-contaminated soil – A military medical perspective
Authors: Finke Ernst-Jürgen , Beyer Wolfgang , Loderstädt Ulrike , Frickmann Hagen 
Published: July 2020

AbstractAnthrax is an infectious disease of relevance for military forces. Although spores of Bacillus anthracis obiquitously occur in soil, reports on soil-borne transmission to humans are scarce. In this narrative review, the potential of soil-borne transmission of anthrax to humans is discussed based on pathogen-specific characteristics and reports on anthrax in the course of several centuries of warfare. In theory, anthrax foci can pose a potential risk of infection to animals and humans if sufficient amounts of virulent spores are present in the soil even after an extended period of time. In praxis, however, transmissions are usually due to contacts with animal products and reported events of soil-based transmissions are scarce. In the history of warfare, even in the trenches of World War I, reported anthrax cases due to soil-contaminated wounds are virtually absent. Both the perspectives and the experience of the Western hemisphere and of former Soviet Republics are presented. Based on the accessible data as provided in the review, the transmission risk of anthrax by infections of wounds due to spore-contaminated soil is considered as very low under the most circumstance. Active historic anthrax foci may, however, still pose a risk to the health of deployed soldiers.
Diagnostic performance of clinic and home blood pressure measurements compared with ambulatory blood pressure: a systematic review and meta-analysis
Authors: Karnjanapiboonwong Auttakiat , Anothaisintawee Thunyarat , Chaikledkaew Usa , Dejthevaporn Charungthai , Attia John , Thakkinstian Ammarin 
Published: July 2020

Abstract
Background: Clinic blood pressure measurement (CBPM) is currently the most commonly used form of screening for hypertension, however it might have a problem detecting white coat hypertension (WCHT) and masked hypertension (MHT). Home blood pressure measurement (HBPM) may be an alternative, but its diagnostic performance is inconclusive relative to CBPM. Therefore, this systematic review aimed to estimate the performance of CBPM and HBPM compared with ambulatory blood pressure measurement(ABPM) and to pool prevalence of WCHT and MHT. Methods: Medline, Scopus, Cochrane Central Register of Controlled Trials and WHO's International Clinical Trials Registry Platform databases were searched up to 23rd January 2020. Studies having diagnostic tests as CBPM or HBPM with reference standard as ABPM which reported sensitivity and specificity of both tests and/or proportion of WCHT or MHT were eligible. Diagnostic performance of CBPM and HBPM were pooled using bivariate mixed-effect regression model. Random effect model was applied to pool prevalence of WCHT and MHT. Results: Fifty-eight studies were eligible. Pooled sensitivity, specificity, and diagnostic odds ratio (DOR) of CBPM, when using 24-hour ABPM as the reference standard, were 74%(95%CI:65%-82%), 79%(95%CI:69%, 87%), and 11.11(95%CI:6.82, 14.20), respectively. Pooled prevalence of WCHT and MHT were 0.24 (95% CI: 0.19, 0.29) and 0.29 (95% CI: 0.20, 0.38). Pooled sensitivity, specificity, and DOR of HBPM were 71%(95%CI:61%, 80%), 82%(95%CI:77%, 87%), and 11.60(95% CI: 8.98, 15.13), respectively. Conclusions: Diagnostic performances of HBPM were slightly higher than CBPM. However, the prevalence of MHT was high in negative CBPM and some persons with normal HBPM had elevated BP from 24-hour ABPM. Therefore, ABPM is still necessary for confirming the diagnosis of HT.
The gut bacterial diversity of sheep associated with different breeds in Qinghai province
Authors: Chang Jianjun , Yao Xiaoting , Zuo Chenxiang , Qi Yuxu , Chen Dekun , Ma Wen-Tao 
Published: July 2020

Abstract
Background: Gut microbiota play important roles in their co-evolution with mammals. However, little is understood about gut bacterial community of Tibetan sheep compared with other sheep breeds. In this study, we investigated the gut bacterial community in 4 different sheep breeds living in the Qinghai-Tibetan Plateau (QTP) of China using high-throughput sequencing (HTS) technique. Results: The results suggested that bacterial community abundance and breeds diversity of Tibetan sheep (TS) were significantly lower than that of the other three breeds of sheep [Dorset sheep (DrS), Dorper sheep (DrS) and Small Tail Han sheep (STHS)] (p < 0.05). Principal coordinates analysis (PCoA) and nonmetric multidimensional scaling (NMDS) analysis indicated that microbiome composition of TS was significantly different from that of other three sheep breeds (p < 0.01). Firmicutes was the most predominant microbial phylum in the gut, followed by Bacteroidetes. The gut bacterial community of TS showed higher proportions of phylum Spirochaetes, Proteobacteria and Verrucomicrobia, compared to the other three sheep breeds, but the Deferribacteres was absent in TS. At the genus level, Treponema, Succinivibrio, 5-7N15 and Prevotella showed significantly higher abundance in TS than in the other three sheep breeds (p < 0.05). Conclusions: In this study, we first employed HTS to understand the gut microbiomes among different sheep breeds in QTP of China.
Predictive risk score model for severe fever with thrombocytopenia syndrome mortality based on qSOFA and SIRS scoring system
Authors: Wang Li , Zou Zhiqiang , Ding Kun , Hou Chunguo 
Published: July 2020

Abstract
Background: Severe fever with thrombocytopenia syndrome (SFTS) is a severe systemic virus infectious disease usually having multi-organ dysfunction which resembles sepsis.Methods: Data of 321 patients with laboratory-confirmed SFTS from May 2013 to July 2017 were retrospectively analyzed. Demographic and clinical characteristics, calculated quick sequential organ failure assessment (qSOFA) score and systemic inflammatory response syndrome (SIRS) criteria for survivors and nonsurvivors were compared. Independent risk factors associated with in-hospital mortality were obtained using multivariable logistic regression analysis. Risk score models containing different risk factors for mortality in stratified patients were established whose predictive values were evaluated using the area under ROC curve (AUC).Results: Of 321 patients, 87 died (27.1%). Age (p<0.001) and percentage numbers of patients with qSOFA≥2 and SIRS≥2 (p<0.0001) were profoundly greater in nonsurvivors than in survivors. Age, qSOFA, SIRS score and aspartate aminotransferase (AST) were independent risk factors for mortality for all patients. And qSOFA score was the only common risk factor in all patients, those age≥60 years and those enrolled in the intensive care unit (ICU). A risk score model containing all these risk factors (Model1) has high predictive value for in-hospital mortality in these three groups with AUCs (95% CI): 0.919 (0.883-0.946), 0.929 (0.862-0.944) and 0.815 (0.710-0.894), respectively. A model only including age and qSOFA also has high predictive value for mortality in these groups with AUCs (95% CI): 0.872 (0.830-0.906), 0.885(0.801-0.900) and 0.865 (0.767-0.932), respectively.Conclusions: Risk models containing qSOFA have high predictive validity for SFTS mortality.
Intentional Carbofuran Poisoning in 7 dogs
Authors: Pivariu Dalma , Oros Adrian Nechita , Tabaran Flaviu , Gal Adrian , Martonos Cristian , Nagy Andras Laszlo 
Published: July 2020

Abstract
Background: Carbofuran is a widely used broad-spectrum pesticide that, despite strict regulation and being banned for more than a decade, is still encountered in cases of intentional poisoning in dogs and wildlife. The objective of the study was to provide a complete and detailed description of the pathological, histological and toxicological findings of 7 cases of intentional carbofuran poisoning in dogs.Results: In this retrospective study, 7 cases of carbofuran intoxication recorded from July 2015 to June 2017 were analyzed. Following complete history recording, all cases were examined by complete necropsy and histopathology. Carbofuran intoxication was confirmed in all cases by gas chromatography. The postmortem examination revealed extensive hemorrhaging and congestion located mainly within the respiratory, nervous and cardiovascular systems, accompanied by degeneration and necrosis within the lungs, heart, and kidneys.Conclusions: Although carbamates have been banned in the European Union, carbamate poisoning is still frequently encountered, especially in wild animals. This paper will contribute to a better understanding of the occurrence and pathogenesis of acute carbofuran exposure in dogs and contribute some peculiar pathological features of this type of poisoning to the current literature.
Psychosocial barriers and enablers of exclusive breastfeeding: lived experiences of mothers in low-income townships, North West Province, South Africa
Authors: Witten Chantell Beverley , Claasen Nicole , Kruger Herculina S , Coutsoudis Anna , Grobler Herman 
Published: July 2020

Abstract
Background: Despite national efforts to promote exclusive breastfeeding (EBF), South Africa’s EBF rate is only 32%. The aim of this study was to examine the rate of EBF discontinuation and the lived experiences of breastfeeding mothers at postnatal time points 3-14 days, 4-8 weeks, 10-14 weeks and 20-24 weeks. Methods: This community-based mixed-methods study collected data within a prospective cohort study on socio-demographics, the Edinburgh Postnatal Depression Scale (EPDS) and the Breastfeeding Self-Efficacy Scale-Short Form (BSES-SF) at 6-8 weeks with infant feeding data collected at 4-8, 10-14 and 20-24 weeks from 159 mothers living in low income areas. Six focus groups with 32 mothers with infants aged 6-24 weeks were conducted. Descriptive statistics was used for the quantitative data and thematic analysis for qualitative data.Results: The majority of mothers were unmarried (84.9%), living with family (69.2%) and unemployed (74.2%). EBF decreased from 34% at 4-8 weeks to 9.7% at 20-24 weeks. Mixed feeding with infant formula increased from 17.0% to 30.6% and food feeding from 3.1% to 54.2%. While there were no statistically significant associations between EBF and any of the quantitative socio-demographic variables, in the qualitative data, codes associated with barriers were more than enablers. The themes were Mothers’ attributes (wellbeing, experiences and relationships) with the code mother’s stress the strongest barrier, Mother’s knowledge, attitudes and practices of breastfeeding with the code conventional medicines the strongest barrier, Family environment with the code home setting the strongest barrier, Social environment with public spaces and places a barrier and in Baby cues the code baby stomach ailments the barrier. Within these same themes mother’s positive emotions, benefits of breastfeeding, support in the home, access to information and services from health professionals and baby’s health were strong enabling factors. Conclusions: Low EBF, high mixed feeding and a high EPDS score were explained by the barriers identified in the qualitative data. The data suggests that mothers from low-income households would be better supported through interventions that address food insecurity; family relationships and those that build confidence in mothers and resilience in confronting difficult and hostile breastfeeding environments.
Dolphinfish Movements in the Eastern Pacific Ocean of Mexico Using Conventional and Electronic Tags
Authors: Perle Christopher R. , Snyder Stephanie , Merten Wessley , Simmons Melinda , Dacey Justina , Rodriguez-Sanchez Ruben , O’Sullivan John , Ortega-Garcia Sofia 
Published: July 2020

Abstract
Background The dolphinfish, Coryphaena hippurus, is a fast-swimming, predatory fish exhibiting relatively fast growth and early maturation among marine teleosts. It is an important, potentially renewable resource throughout its global subtropical-to-tropical range. Understanding the ecology of this wide-ranging fish is critical to proper fisheries management, but studies have historically depended heavily upon aggregated catch data reported by fisheries. This study uses tagging data to explore finer scale dolphinfish movements in two subregions of the Eastern Pacific Ocean (EPO) – the west coasts of Baja California Peninsula (WBC) and Oaxaca (OAX), Mexico.Results Adult dolphinfish (fork length 66 cm - 129 cm) were tagged with conventional (n = 132 tags) and electronic tags (n = 30 tags, miniPAT) between 2010 and 2014. Recapture rate of conventional tags was 4.5% with a maximum days of liberty of 141 days (mean = 56 d); twenty electronic tags reported but all did so prior to programmed release dates, with days at liberty ranging from 4 to 62 (mean = 24 d). Fish remained within the region they were tagged except for six fish tagged in WBC and one in OAX. Latitudinal (WBC) and longitudinal (OAX) extensions of observed fish movements (determined via a novel analytical approach) increased with days at liberty. Despite occasional deep dives (max 262 m), fish remained surface oriented with short excursions below the isothermal layer but larger OAX fish (fork length [103 cm, 120 cm]) inhabiting warmer waters (sea surface temperatures (SST) > ~26 °C) spent more time below the isothermal layer than smaller fish (fork length [90 cm,112 cm]) inhabiting colder WBC surface waters (SST > ~22 °C).Conclusions This study reveals movements of dolphinfish that infer regional differences in thermal habitat utilization and displacement over time. This inference evokes questions important to fisheries management regarding the three-dimensional extent of the dolphinfish’s realized thermal niche, its population structure, and the spatiotemporal connectivity of its habitats within the multinational EPO. With improved tag retention, longer deployments should capture increasing displacements along observed axes (N/S vs. E/W); the orientation of seasonal displacement axes suggest longer-distance movements would provide opportunities for reproductive mixing via trans-national migrations.