bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functionality and acceptability of a novel non-invasive neonatal heart rate monitoring device: a qualitative study of healthcare professionals
Authors: Anton Oana , Fernandez Ramon , Rendon-Morales Elizabeth , Aviles-Espinosa Rodrigo , Jones Christina J , Rabe Heike 
Published: July 2020

BackgroundDetecting neonatal heart rate rapidly and accurately at birth is essential if resuscitation is required. The Neo-Sense prototype provides a quick, non-invasive method to measure neonatal heart rate at birth based on electric potential sensing technology. The study aimed to inform the prototype design process by exploring the required features and usability of this novel device among healthcare professionals.MethodsFace-to-face, semistructured interviews were conducted with healthcare professionals involved in the immediate care of babies at birth: paediatricians, midwives and neonatal nurses. Interviews were audio-recorded and subsequently transcribed verbatim. Two independent researchers coded and extracted the emerging categories and performed a thematic content analysis.ResultsIn total, 21 participants were interviewed, 7 from each professional group. Participants expressed a positive attitude towards the novel prototype. The three main themes extracted were anticipated limitations, advantages and suggestions for development and usage. Participants preferred a device that is easy to use and attach, one which is positioned in a mattress or pad, maintaining also the option of being mobile. Education was considered to have a key role in addressing staff anxiety. The ideal features most frequently mentioned were speed of assessment, reliability and accuracy.ConclusionsThe study enabled a better understanding of the perceived barriers and facilitators to developing a new heart rate monitoring device. The development of a quick and accurate device would have immense implications for clinical practice and the potential to improve neonatal mortality and morbidity.
Connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment-resistant moderate to severe depression: study protocol for a randomised double-blind controlled trial (BRIGhTMIND)
Authors: Morriss Richard , Webster Lucy , Abdelghani Mohamed , Auer Dorothee P , Barber Shaun , Bates Peter , Blamire Andrew , Briley Paul M , Brookes Cassandra , Iwabuchi Sarina , James Marilyn , Kaylor-Hughes Catherine , Lankappa Sudheer , Liddle Peter , McAllister-Williams Hamish , O'Neill-Kerr Alex , Pszczolkowski Parraguez Stefan , Suazo Di Paola Ana , Thomson Louise , Walters Yvette 
Published: July 2020

IntroductionThe BRIGhTMIND study aims to determine the clinical effectiveness, cost-effectiveness and mechanism of action of connectivity guided intermittent theta burst stimulation (cgiTBS) versus standard repetitive transcranial magnetic stimulation (rTMS) in adults with moderate to severe treatment resistant depression.Methods and analysisThe study is a randomised double-blind controlled trial with 1:1 allocation to either 20 sessions of (1) cgiTBS or (2) neuronavigated rTMS not using connectivity guidance. A total of 368 eligible participants with a diagnosis of current unipolar major depressive disorder that is both treatment resistant (defined as scoring 2 or more on the Massachusetts General Hospital Staging Score) and moderate to severe (scoring >16 on the 17-item Hamilton Depression Rating Scale (HDRS-17)), will be recruited from primary and secondary care settings at four treatment centres in the UK. The primary outcome is depression response at 16 weeks (50% or greater reduction in HDRS-17 score from baseline). Secondary outcomes include assessments of self-rated depression, anxiety, psychosocial functioning, cognition and quality of life at 8, 16 and 26 weeks postrandomisation. Cost-effectiveness, patient acceptability, safety, mechanism of action and predictors of response will also be examined.Ethics and disseminationEthical approval was granted by East Midlands Leicester Central Research Ethics Committee (ref: 18/EM/0232) on 30 August 2018. The results of the study will be published in relevant peer-reviewed journals, and then through professional and public conferences and media. Further publications will explore patient experience, moderators and mediators of outcome and mechanism of action.Trial registration numberISRCTN19674644
Prevalence of acute liver injury and hypertransaminemia in patients with COVID-19: a protocol for a systematic review
Authors: Li Gang , Xu Yongxing , Yang Yi Tian , Liu Peng Fei 
Published: July 2020

IntroductionCOVID-19 has spread rapidly in China and around the world. Published studies have revealed that some patients with COVID-19 had abnormal liver function in laboratory tests. However, the results were inconsistent and the analysis of epidemiological data stratified by the severity of COVID-19 was not available in previous meta-analyses. Furthermore, these meta-analyses were suspected of overestimating the incidence of liver injury in patients with COVID-19 because some studies considered transaminase elevation as liver injury, which might partially result from cardiac and muscle injury. This systematic review aims to enrol published literatures related to COVID-19 without language restriction, analyse the data based on the severity of the COVID-19 and explore the impact of varied definitions of liver injury on the incidence of liver injury.Methods and analysisWe have conducted a preliminary search on PubMed and Excerpta Medica Database on 13 April 2020, for the studies published after December 2019 on the prevalence of acute liver injury and hypertransaminemia in patients with COVID-19. Two reviewers will independently screen studies, extract data and assess the risk of bias. We will estimate the pooled incidence of hypertransaminemia and acute liver injury in patients with COVID-19 by using the random-effects model. The I² test will be used to identify the extent of heterogeneity. Publication bias will be assessed by funnel plot and performing the Begg’s and Egger’s test if adequate studies are available. We will perform a risk of bias assessment using the Joanna Briggs Institute’s critical appraisal checklist.Ethics and disseminationSince this study will be based on the published data, it does not require ethical approval. The final results of this study will be published in a peer-reviewed journal.PROSPERO registration numberCRD42020179462.
Differences in SARS-CoV-2 recommendations from major ophthalmology societies worldwide
Authors: Nguyen Anne X , Gervasio Kalla A , Wu Albert Y 
Published: July 2020

ObjectiveSince the WHO declared the COVID-19 outbreak as a public health emergency, medical societies around the world published COVID-19 recommendations to physicians to ensure patient care and physician safety. During this pandemic, ophthalmologists around the world adapted their clinical and surgical practice following such guidelines. This original research examines all publicly available COVID-19 recommendations from twelve major ophthalmology societies around the world.Methods and analysisTwelve ophthalmology societies recognised by the International Council of Ophthalmology were included in this study. One society per each WHO region was included: the society selected was the one who had the highest number of national COVID-19 confirmed cases on 11 May 2020. In addition to these countries, the major ophthalmology society in each G7 country was included.ResultsTen out of 12 major international ophthalmology societies from countries covering all six WHO regions have given recommendations regarding urgent patient care, social distancing, telemedicine and personal protective equipment when caring for ophthalmic patients during the COVID-19 pandemic. While all guidelines emphasise the importance of postponing non-urgent care and taking necessary safety measures, specific recommendations differ between countries.ConclusionsAs there is no clear consensus on ophthalmology guidelines across countries, this paper highlights the differences in international ophthalmic care recommendations during the COVID-19 pandemic. Knowledge of the differences in ophthalmic management plans will allow ophthalmologists and all eye care providers to consider the variety of international approaches and apply best practices following evidence-based recommendations during pandemics.
Association between right ventricle dysfunction and poor outcome in patients with septic shock
Authors: Kim June-sung , Kim Youn-Jung , Kim Muyeol , Ryoo Seung Mok , Kim Won Young 
Published: July 2020

ObjectiveSepsis-induced myocardial dysfunction (SIMD) can involve both the left and right ventricles. However, the characteristics and outcomes across various manifestations of SIMD remain unknown.MethodsThis was a retrospective cohort study using a prospective registry of septic shock from January 2011 and April 2017. Patients with clinically presumed cardiac dysfunction underwent echocardiography within 72 hours after admission and were enrolled (n=778). SIMD was classified as left ventricle (LV) systolic/diastolic and right ventricle (RV) dysfunction, which were defined based on the American Society of Echocardiography criteria. The primary outcome was 28-day mortality.ResultsOf the 778 septic shock patients who underwent echocardiography, 270 (34.7%) showed SIMD. The median age was 67.0 years old, and the male was predominant (57.3%). Among them, 67.3% had LV systolic dysfunction, 40.7% had RV dysfunction and 39.3% had LV diastolic dysfunction. Although serum lactate level and sequential organ failure assessment score were not significantly different between groups, SIMD group showed higher troponin I (0.1 vs 0.1 ng/mL; p=0.02) and poor clinical outcomes, including higher 28-day mortality (35.9 vs 26.8%; p<0.01), longer intensive care unit length of stay (5 vs 2 days; p<0.01) and prolonged mechanical ventilation (9 vs 4 days; p<0.01). Multivariate analysis showed that isolated RV dysfunction was an independent risk factor of 28-day mortality (OR 2.26, 95% CI 1.04 to 4.91).ConclusionsOne-third of patients with septic shock showed various myocardial dysfunctions. LV systolic dysfunction was common; however, only RV dysfunction was associated with short-term mortality.
Tandem stents thrombectomy as a rescue treatment for refractory large vessel occlusions
Authors: Xu Haowen , Peng Shanling , Quan Tao , Yuan Yongjie , Wang Zibo , Fu Xiaojie , Han Kaihao , Liu Guo , Guan Sheng , Li Panxing 
Published: July 2020

BackgroundMechanical thrombectomy with a stent retriever (SR) and/or aspiration is the "gold standard" for the treatment of acute ischemic stroke due to large vessel occlusion (LVO). However, sometimes clots may not be retrievable with a single SR alone or combined with aspiration.ObjectiveTo assess the safety and efficacy of a novel tandem stents thrombectomy (TST) technique as a rescue treatment for acute LVO that is refractory to conventional attempts.MethodsAll patients treated with the TST technique as rescue treatment after failure of conventional attempts were retrospectively reviewed. The postprocedural angiographic and clinical outcome, including modified Thrombolysis in Cerebral infarction (mTICI) grade, National Institutes of Health Stroke Scale (NIHSS) score, and modified Rankin Scale (mRS) score, was assessed.ResultsNine patients (mean age, 65.2 years; median NIHSS score 18) with middle cerebral artery M1 segment (n=6) and terminal internal carotid artery (n=3) occlusions were included in the study. The TST technique was performed as a rescue treatment after unsuccessful stent thrombectomy alone (four cases) and stent thrombectomy plus aspiration (five cases). Successful recanalization (mTICI 2b/3) was achieved in all patients. No procedure-related complications occurred except reversible vasospasms were observed in three patients and one patient developed hemorrhage transformation after the procedure, but was asymptomatic. Three patients had good clinical outcome (mRS score 0–2 at 90 days). Two patients (22.2%) died.ConclusionsThe TST technique seems to be a safe and effective rescue treatment for acute LVO that is refractory to conventional attempts.
Increased primary care use for musculoskeletal symptoms, infections and comorbidities in the years before the diagnosis of inflammatory arthritis
Authors: Beers-Tas Marian van , Nielen Markus MJ , Twisk Jos W R , Korevaar Joke , van Schaardenburg D 
Published: July 2020

ObjectivesLittle is known about relevant events in the at-risk phase of rheumatoid arthritis before the development of clinically apparent inflammatory arthritis (IA). The present study assessed musculoskeletal symptoms, infections and comorbidity in future IA patients.MethodsIn a nested case–control study using electronic health records of general practitioners, the frequency and timing of 192 symptoms or diseases were evaluated before a diagnosis of IA, using the International Classification of Primary Care coding system. Cases were 2314 adults with a new diagnosis IA between 2012 and 2016; controls were matched 1:2. The frequency of primary care visits was compared using logistic regression.ResultsThe frequency of visits for musculoskeletal symptoms (mostly of shoulders, wrists, fingers and knees) and carpal tunnel syndrome was significantly higher in IA patients vs controls within the final 1.5 years before diagnosis, with ORs of 3.2 (95% CI 2.8 to 3.5), 2.8 (95% CI 2.5 to 3.1) and 2.5 (95% CI 2.2 to 2.8) at 6, 12 and 18 months before diagnosis, respectively. Also, infections (notably of the genital and urinary tracts), IA-comorbidities and chronic diseases were more prevalent in cases than controls, but more evenly spread out over the whole 6-year period before IA. A decision tree was created including all symptoms and diseases.ConclusionThere was an increased frequency of primary care visits for musculoskeletal symptoms, infections and comorbidities prior to the diagnosis of IA. This diverging trend is present for 4–6 years, but becomes statistically significant 1.5 years before the diagnosis. Validation of these results is warranted.
Revisiting the stability of quadratic Poincaré gauge gravity
Authors: Jiménez Jose Beltrán , Torralba Francisco José Maldonado 
Published: July 2020

AbstractPoincaré gauge theories provide an approach to gravity based on the gauging of the Poincaré group, whose homogeneous part generates curvature while the translational sector gives rise to torsion. In this note we revisit the stability of the widely studied quadratic theories within this framework. We analyse the presence of ghosts without fixing any background by obtaining the relevant interactions in an exact post-Riemannian expansion. We find that the axial sector of the theory exhibits ghostly couplings to the graviton sector that render the theory unstable. Remarkably, imposing the absence of these pathological couplings results in a theory where either the axial sector or the torsion trace becomes a ghost. We conclude that imposing ghost-freedom generically leads to a non-dynamical torsion. We analyse however two special choices of parameters that allow a dynamical scalar in the torsion and obtain the corresponding effective action where the dynamics of the scalar is apparent. These special cases are shown to be equivalent to a generalised Brans–Dicke theory and a Holst Lagrangian with a dynamical Barbero–Immirzi pseudoscalar field respectively. The two sectors can co-exist giving a bi-scalar theory. Finally, we discuss how the ghost nature of the vector sector can be avoided by including additional dimension four operators.
Conference report: The 27th ACM SIGSPATIAL International Conference on Advances in Geographic Information Systems (ACM SIGSPATIAL 2019)
Authors: Güting Ralf Hartmut , Kulik Lars , Newsam Shawn , Banaei-Kashani Farnoush , Trajcevski Goce 
Published: July 2020

This report describes the development and finalization of the 27th ACM SIGSPATIAL International Conference on Advances in Geographic Information Systems (ACM SIGSPATIAL 2019), held in Chicago, Illinois, USA, November 5-8, 2019. The attendance for the 2019 conference was 397, the second highest in the history of ACM SIGSPATIAL.
Historically, what is now the ACM SIGSPATIAL conference started as a series of workshops and symposia in 1993. Its aim was to promote the interdisciplinary discussions among researchers, developers, users, and practitioners and fostering research in all aspects of Geographic Information Systems --- hence the original workshop acronym ACM GIS. The focus was on novel systems based on geospatial data and knowledge. It continued its mission of providing a forum for original research results, addressing conceptual, design, and implementation aspects of geospatial data ranging from applications, user interfaces and visualization, to data storage, query processing, indexing and data mining. The conference is now the premier annual event of the ACM Special Interest Group on Spatial Information (ACM SIGSPATIAL).
Effect of COVID-19 on Emergent Stroke Care
Authors: Hsiao Jessica , Sayles Emily , Antzoulatos Eleni , Stanton Robert J. , Sucharew Heidi , Broderick Joseph P. , Demel Stacie L. , Flaherty Matthew L. , Grossman Aaron W. , Kircher Charles , Kreitzer Natalie , Peariso Katrina , Prestigiacomo Charles J. , Shirani Peyman , Walsh Kyle B. , Lampton Holly , Adeoye Opeolu , Khatri Pooja 
Published: July 2020

Background and Purpose:
Anecdotal evidence suggests that the coronavirus disease 2019 (COVID-19) pandemic mitigation efforts may inadvertently discourage patients from seeking treatment for stroke with resultant increased morbidity and mortality. Analysis of regional data, while hospital capacities for acute stroke care remained fully available, offers an opportunity to assess this. We report regional Stroke Team acute activations and reperfusion treatments during COVID-19 mitigation activities.

Methods:
Using case log data prospectively collected by a Stroke Team exclusively serving ≈2 million inhabitants and 30 healthcare facilities, we retrospectively reviewed volumes of consultations and reperfusion treatments for acute ischemic stroke. We compared volumes before and after announcements of COVID-19 mitigation measures and the prior calendar year.

Results:
Compared with the 10 weeks prior, stroke consultations declined by 39% (95% CI, 32%–46%) in the 5 weeks after announcement of statewide school and restaurant closures in Ohio, Kentucky, and Indiana. Results compared with the prior year and time trend analyses were consistent. Reperfusion treatments also appeared to decline by 31% (95% CI, 3%–51%), and specifically thrombolysis by 33% (95% CI, 4%–55%), but this finding had less precision.

Conclusions:
Upon the announcement of measures to mitigate COVID-19, regional acute stroke consultations declined significantly. Reperfusion treatment rates, particularly thrombolysis, also appeared to decline qualitatively, and this finding requires further study. Urgent public education is necessary to mitigate a possible crisis of avoiding essential emergency care due to COVID-19.
Weaving the Body and the Cosmos
Authors: Apffel-Marglin Frédérique , Jean Julia A. 
Published: July 2020

Abstract
This paper explores the cultural context and ecological implications of two menstrual festivals in northeastern India: Rajaparba in Orissa and Ambuvaci in Kamakhya, Assam. We argue that these festivals are extremely fruitful sites to explore questions of women and power in religious communities where the Goddess is a central focus as well as their ecological implications for an integral worldview. These festivals, usually held at the beginning of the monsoon when the Hindu Goddess menstruates, are times when the earth is regenerated, when the body of the Goddess is regenerated, and when women and communities are regenerated in various ways. Participants report that pilgrimages to these festivals are indeed transformative and have positive impacts on their lives. As a result, we critique feminist arguments that claim that Hinduism is the basis for women’s social disempowerment, and as a result, the only meaningful social change must occur on a secular basis. We also use these festivals to critique contemporary feminist developmentalist ideologies.
The Use of Paravertebral Analgesia in the Management of Pain in the Elderly Patient With Rib Fractures
Authors: Wasfie Tarik , Howell Adam , Cwalina N , Yapchai Raquel , Hille Jennifer , Hella Jennifer , Shapiro Brian , Barber Kimberly R. 
Published: July 2020

Background Elderly patients with rib fractures carry a high morbidity rate, particularly due to pulmonary complications as decreased respiratory efforts ensue secondary to pain. Risk of bleeds in the elderly on anticoagulant therapy is high. The effort to reduce narcotic use in patients is now a health care priority. We propose that the use of paravertebral analgesia (PVA) pumps is an alternative pain control method with less risk and easy placement. Methods Two hundred and seventy-nine patients were admitted with multiple fractured ribs to the Trauma Center of Community Hospital and treated with the application of continuous PVA via a pump (72 patients). Pain scores were recorded before and after the initiation of the pump. These patients were compared with a group of the remaining 207 patients who received intravenous narcotics only. Results The mean change from baseline in pain scores for all patients was 1.43 (SD = 2.75). The mean change in pain for the treatment group was 1.93 (SD = 2.60), and the change in pain for the control group was 1.24 (SD = 2.79). Change in pain differed between groups (1.3 vs 1.8; P = .01) although it was a small difference. After adjusting for age, gender, Injury Severity Score, Glasgow Coma Scale, number of fractures, and comorbid conditions, there was no significant difference in pain post-procedure (odds ratio = 0.75; P = 0.39) with an effect size of 30% and total sample size of 279. Conclusion The PVA pump using bupivacaine is an effective safe and alternative method for managing elderly patients with rib fractures eliminating the serious side effects associated with narcotics.