bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quick response and omnichannel retail operations with the ship‐to‐store program
Authors: Yang Daojian , Zhang Xiujie 
Published: February 2020

AbstractTo better integrate online businesses with offline stores, fast‐fashion retailers roll out the “ship‐to‐store” (STS) initiative, which is an omnichannel fulfillment method that allows consumers to order online and have their parcels delivered to selected stores for pickup. To study the impact of STS on fast‐fashion operations, we consider four scenarios: multichannel retailing, multichannel retailing with quick response (QR), omnichannel retailing with STS, and omnichannel retailing with both STS and QR. Moreover, we investigate how STS influences the value of QR. The results show that although STS benefits firms in many situations, STS under a QR strategy can reduce a retailer's profits when inventory information disclosure due to STS dampens cross‐selling opportunities. Our findings also reveal that the implementation of STS may lower the value of QR when customers who encounter stockouts offline opt to purchase online directly rather than use STS.
Root and shoot responses of upland New Rice for Africa varieties to fluctuating soil moisture conditions as affected by different levels of nitrogen fertilization
Authors: Menge Daniel Makori , Kano‐Nakata Mana , Yamauchi Akira , Suralta Roel Rodriguez , Makihara Daigo 
Published: February 2020

AbstractDrought cycling and soil re‐watering trends due to intermittent rainfall patterns are key stress factors that influence rice growth and yield under upland cultivation conditions. However, upland rice adaptation responses to fluctuating soil moisture conditions remain poorly understood. This study investigated root and shoot responses of upland New Rice for Africa (NERICA) varieties to episodic drought and re‐watering during growth. We examined root and shoot growth of NERICA 1 and NERICA 4 compared with those of IR72, an improved lowland variety, and Dular, a traditional drought‐tolerant variety, in terms of soil moisture fluctuations with different levels of nitrogen fertilization under field conditions that impeded deep root development. During soil moisture fluctuation, all varieties reduced shoot dry weight compared with well‐watered plants, regardless of nitrogen fertilization levels. However, total root length for the three upland varieties was enhanced by soil moisture fluctuations at moderate and high nitrogen fertilization, while that of the lowland variety was reduced. Comparing root development during water fluctuations revealed that NERICA 1 had a greater root system than NERICA 4, which was attributed to lateral root development. Furthermore, we found that NERICA varieties increase lateral root mass during soil desiccation under adequate nitrogen fertilization, while Dular and IR72 reduced their root growth rate during drought and increased it after re‐watering. Both root growth patterns developed, from around maximum tillering to heading. The analysis of regression between root elongation and shoot growth with fluctuating soil moisture indicated that an enhanced root system during drought, on adequate nitrogen fertilization, can contribute to shoot growth when sufficient water becomes available, specifically around the maximum tillering to the heading growth stage of rice.
Transition in temperature scaling behaviors and super temperature stable polarization in BiScO3–PbZrO3–PbTiO3 system
Authors: Hu Querui , Yang Ying , Li Ling , Wang Yiping , Chen Lang , Yuan Guoliang , Zhang Shantao 
Published: February 2020

AbstractTemperature scaling of dynamic ferroelectric hysteresis for the morphotropic phase boundary (MPB) compositions in xBiScO3–(1‐x‐y)PbZrO3–yPbTiO3 (xBS–(1‐x‐y)PZ–yPT, 0.018 ≤ x ≤ 0.264) ternary system was systematically investigated. The power‐law relation was obtained for remanent polarization Pr and temperature T, that is, Pr ∝ Tβ. It is interesting to find that the power‐law exponent β could be modulated by BiScO3 content x. With the increase of x from 0.018 to 0.264, β varies from −1.09398 to 2.44147. Transition of β from negative to positive produces in the vicinity of 0.054BS–0.476PZ–0.470PT ceramic. At this composition, the magnitude of β is very close to zero with value of only −0.01567, implying an almost temperature‐independent polarization characteristic of the ceramic. Comparing with the conventional PZT‐based piezoelectric ceramics that usually with negative exponent β, when x > 0.054, the xBS–(1‐x‐y)PZ–yPT ceramics show positive β value, so that the ferroelectric polarization is enhanced with increasing temperature. Such a positive temperature dependence of ferro‐/piezoelectric property makes the ternary system a promising candidate for high‐temperature applications.
Himalayan wolf distribution and admixture based on multiple genetic markers
Authors: Werhahn Geraldine , Liu Yanjiang , Meng Yao , Cheng Chen , Lu Zhi , Atzeni Luciano , Deng Zhixiong , Kun Shi , Shao Xinning , Lu Qi , Joshi Jyoti , Man Sherchan Adarsh , Karmacharya Dibesh , Kumari Chaudhary Hemanta , Kusi Naresh , Weckworth Byron , Kachel Shannon , Rosen Tatjana , Kubanychbekov Zairbek , Karimov Khalil , Kaden Jennifer , Ghazali Muhammad , Macdonald David W. , Sillero‐Zubiri Claudio , Senn Helen 
Published: February 2020

AbstractAimWe explore the phylogeography of Himalayan wolves using multiple genetic markers applied on a landscape‐scale dataset and relate our findings to the biogeographic history of the region.LocationHimalayas of Nepal, the Tibetan Plateau of China and mountain ranges of Central Asia.TaxonHimalayan wolf (also called the Tibetan wolf), Canis lupus chanco.MethodsWe present a large‐scale, non‐invasive study of Himalayan wolves from across their estimated range. We analysed 280 wolf scat samples from western China, Kyrgyzstan and Tajikistan at two mtDNA loci, 17 microsatellite loci, four non‐synonymous SNPs in three nuclear genes related to the hypoxia pathway, and ZF genes on both sex chromosomes.ResultsOur results corroborate previous studies showing that the Himalayan wolf forms a distinct lineage adapted to high altitudes in excess of 4,000 m elevation. We found a correlation between hypoxia adaptation and the divergent Himalayan wolf mtDNA haplotype found across the Tibetan Plateau of Qinghai, the Tibetan Autonomous Region and the Nepalese Himalayas. We identified a region of admixture between Himalayan and grey wolves at the boundary of their distributions, where the Tibetan Plateau elevation gradually drops.Main ConclusionBased on multiple genetic markers, the Himalayan wolf forms a reciprocally monophyletic lineage with a unique adaptation to high altitude. We propose that the divergence of the lineage is related to past uplift of the region, and that the lineage maintains its high‐altitude niche, in part, by means of its genetic adaptation to hypoxia. We conclude that the Himalayan wolf merits taxonomic recognition and designation as an evolutionary significant unit (ESU).
Effects of providing partial hypotheses as a support for simulation‐based inquiry learning
Authors: Kuang Xiulin , Eysink Tessa H.S. , de Jong Ton 
Published: February 2020

AbstractHypothesis generation is an important but difficult process for students. This study investigated the effects of providing students with support for hypothesis generation, with regard to the testability and complexity of the generated hypotheses, the quality of the subsequent inquiry learning processes and knowledge acquisition. Fifty‐two secondary school students completed three prior knowledge tests and worked on an inquiry task in the domain of force and motion, concerning the topic of Newton's first law of motion. They received either a set of terms (variables, conditions and relations) to help them generate hypotheses (T condition, n = 23) or the same set of terms plus a partial hypothesis to start from (T + PHy condition, n = 29). Results showed that students in the T + PHy condition generated more complex hypotheses, performed better at data collection and acquired more domain knowledge than students in the T condition. No effects of prior knowledge were found.
Treatment of acne with spironolactone: a retrospective review of 395 adult patients at Mayo Clinic, 2007–2017
Authors: Roberts E.E. , Nowsheen S. , Davis M.D.P. , McEvoy M.T. , Newman C.C. , Sartori Valinotti J.C. , Sciallis G.F. , Torgerson R.R. , Wetter D.A. 
Published: February 2020

AbstractBackgroundFew large studies have assessed spironolactone treatment of adult female acne.ObjectivesTo explore the role of spironolactone in the treatment of adult female acne.MethodsWe performed a retrospective case series assessing the efficacy of spironolactone treatment of a cohort of women evaluated at Mayo Clinic in Rochester, Minnesota, from 2007 through 2017.ResultsIn total, 395 patients (median age, 32 years) received a median spironolactone dose of 100 mg daily. Approximately two‐thirds of patients (66.1%) had a complete response; 85.1% had a complete response or a partial response greater than 50%. Median times to initial response and maximum response were 3 and 5 months. Efficacy was observed across all severity subtypes of acne, including those with papulopustular and nodulocystic acne. Patients received long‐term treatment with spironolactone (median duration, 13 months) and had few adverse effects.ConclusionsSpironolactone is a safe and effective treatment of acne for women.
The top 100 most cited articles in rosacea: a bibliometric analysis
Authors: Wang Y. , Zhang H. , Fang R. , Tang K. , Sun Q. 
Published: February 2020

AbstractBackgroundMany articles in rosacea have been published. Bibliometric analysis is helpful to determine the most influential studies in a specific field.ObjectiveTo identify the top 100 most cited articles in rosacea using the bibliometric analysis method.MethodsWe searched in the Web of Science database on 20 November 2019. Articles were listed in descending order by their total citations. The top 100 most cited articles in rosacea were identified and analysed.ResultsThe top 100 most cited articles were published between 1971 and 2015. The largest number of articles was published in a single interval in 2011–2015. The average annual citations were constantly ascending, and the total citations were positively correlated with annual citations. The 100 articles were classified into different research focuses: treatment (35%), pathogenesis (27%), clinical features and diagnosis (14%), pathophysiology (6%), associated diseases (4%), epidemiology (3%) and others (11%). A total of 19 articles were randomized controlled trials (RCT), 14 focused on the association between rosacea and Demodex, and five focused on the association between rosacea and Helicobacter pylori. Twenty‐five publications focused on a specific subtype of rosacea, mainly papulopustular and ocular rosacea. The 100 articles were published in 32 journals. A total of 79 different first corresponding authors were from 20 different countries, mostly in North America and Europe. Steinhoff. M from University of California published the most articles as the corresponding author.ConclusionsThis study identified the top 100 most cited articles in rosacea and analysed their bibliometric characteristics, which may pave the way for further research.
Synergistic effect of peppermint and garlic essential oil on fate of Kluyveromyces marxianus in Zucchini Bouranee
Authors: Fadavi Alireza , Pajohi‐Alamoti Mohammadreza , Karami Mostafa 
Published: February 2020

AbstractThe purpose of the study was to evaluate the inhibitory effect of garlic (GEO) and peppermint (PEO) essential oils on Kluyveromyces marxianus (K. marxianus) in zucchini bouranee and also to assess the product's functional physicochemical properties during storage. The results showed that the combined use of the GEO and PEO caused a faster decrease in the yeast count. The growth rate of K. marxianus reduced significantly with increasing the EOs concentration (p < .05). No significant difference was found between amounts of the dry matter of the treatments until the 14th day. The syneresis percentages were significantly different between the treatments during storage. Meanwhile, the GEO treatments had a higher syneresis rate compared with the PEO treatments (p < .05). The organoleptic assays showed that the GEO 0.05% treatment obtained the highest score. As a result, the antimicrobial properties of the EOs, especially GEO, could increase the zucchini bouranee shelf life.
Effect of chitosan edible coating enriched with lemon verbena extract and essential oil on the shelf life of vacuum rainbow trout (Oncorhynchus mykiss)
Authors: Rezaeifar Maryam , Mehdizadeh Tooraj , Mojaddar Langroodi Ali , Rezaei Fatemeh 
Published: February 2020

AbstractIn this research, the antioxidant and antibacterial characteristics of the chitosan (CH) coating incorporated with lemon verbena essential oil (LVEO) and extract (LVE) on the quality of the rainbow trout packed by vacuum packaging at 4°C were investigated. Samples evaluated include the following: Control, VP, CH, CH‐LVE 2%, CH‐LVEO 1%, and CH‐LVE 1%‐LVEO 0.5% for 16 days at 3 days intervals. All of the samples significantly reduced Psychrotrophic bacteria, total viable counts, Enterobacteriaceae, and H2S producing bacteria as compared with control during keeping time. Thiobarbituric acid reactive substance, peroxide value, total volatile basic nitrogen, and pH value were detected lower in all of the samples than control. CH incorporated with LVE and LVEO gave an agreeable effect on sensory characteristics. Samples containing CH‐LVE 1%‐LVEO 0.5% was often in priority by sensory assessors. Generally, LV can be applied as a substitution for chemical preservatives in fish meat.
Genotype‐phenotype correlation in a novel ABHD12 mutation underlying PHARC syndrome
Authors: Thimm Andreas , Rahal Ahmad , Schoen Ulrike , Abicht Angela , Klebe Stephan , Kleinschnitz Christoph , Hagenacker Tim , Stettner Mark 
Published: February 2020

AbstractPHARC syndrome is a rare neurodegenerative disorder caused by mutations in the ABHD12 gene. It is a genetically heterogeneous and clinically variable disease, which is characterized by demyelinating polyneuropathy, hearing loss, cerebellar ataxia, retinitis pigmentosa, and early‐onset cataract and can easily be misdiagnosed as other neurologic disorders with a similar clinical picture, such as Charcot‐Marie‐Tooth disease and Refsum disease. We describe the genotype‐phenotype correlation of two siblings with a novel genotype underlying PHARC syndrome. The genotype was identified using next‐generation sequencing. We examined both patients by means of thorough history taking and clinical examination, nerve conduction studies (NCS), brain imaging, and optical coherence tomography to establish a genotype‐phenotype correlation. We identified a novel homozygous point mutation (c.784C > T, p.Arg262*) in the ABHD12 gene. This mutation was detected in both siblings, who had bilateral hearing loss and cataracts, signs of cerebellar ataxia, and neuropathy with a primarily demyelinating pattern in NCS. In one case, retinitis pigmentosa was also evident. As PHARC syndrome is a rare autosomal recessive disorder, our findings highlight the importance of an interdisciplinary diagnostic workup with clinical and molecular genetic testing to avoid a misdiagnosis as Charcot‐Marie‐Tooth disease or Refsum disease.
Family caregiver's burden and the social support for older patients undergoing peritoneal dialysis
Authors: Tao Xingjuan , Chow Susan Ka Yee , Zhang Haifen , Huang Jiaying , Gu Aiping , Jin Yan , He Yanna , Li Na 
Published: February 2020

SUMMARYBackgroundMost elderly people undergoing peritoneal dialysis (PD) treatment have a high incidence of frailty, cognitive impairment and emotional disturbance leading to a significant impact on families. The burden experienced by the family caregivers could affect their physical and emotion health. The objective of this study was to examine the level of burden on family caregivers of elderly adults receiving PD and to identify any contributing factors.Materials and MethodsThis was a cross‐sectional study employing convenience sampling. Patient–caregiver dyads were recruited from the outpatient clinic of a university hospital in China in 2019. Caregivers provided information on their perceived burden and health‐related quality of life. The elderly patients reported their functional dependence and depressive symptoms in the same interview. Linear regression analyses were used to determine the factors contributing to caregivers’ burden.ResultsSixty patient–caregiver dyads were recruited. The patients had a mean age of 70.7 ± 7.4 years. The caregivers reported moderate levels of burden having ZBI score of 30.5 ± 15.9. Multivariate analyses showed that being female, perceiving one's financial status as insufficient, a low level of social support for the caregiver, depressive symptoms in the patients and disability in carrying out the instrumental activities of daily life were statistically significant predictors of caregiver burden (adjusted R2 = 0.46, p < 0.001).ConclusionElderly adults receiving PD who experience physical dependence and depressive symptoms are a burden for caregivers. In response to this challenge, interventions designed with the goal of supporting the emotional and mental wellbeing of caregivers are warranted.
Impact of Rurality on Stage IV Ovarian Cancer at Diagnosis: A Midwest Cancer Registry Cohort Study
Authors: Weeks Kristin S. , Lynch Charles F. , West Michele , McDonald Megan , Carnahan Ryan , Stewart Sherri L. ,   Ovarian Cancer Treatment Study, Charlton Mary 
Published: February 2020

AbstractPurposeWe aim to understand if rurality impacts patients’ odds of presenting with stage IV ovarian cancer at diagnosis independent of distance to primary care provider and the socioeconomic status of a patient's residential census tract.MethodsA cohort of 1,000 women with ovarian cancer in Iowa, Kansas, and Missouri were sampled and analyzed from the cancer registries’ statewide population data. The sample contained those with a histologically confirmed primary ovarian cancer diagnosis in 2011‐2012. All variables were captured through an extension of standard registry protocol using standardized definitions and abstraction manuals. Chi‐square tests and a multivariable logistic regression model were used.FindingsAt diagnosis, 111 women in our sample had stage IV cancer and 889 had stage I‐III. Compared to patients with stage I‐III cancer, patients with stage IV disease had a higher average age, more comorbidities, and were more often living in rural areas. Multivariate analysis showed that rural women (vs metropolitan) had a greater odds of having stage IV ovarian cancer at diagnosis (odds ratio = 2.41 and 95% confidence interval = 1.33‐4.39).ConclusionRural ovarian cancer patients have greater odds of having stage IV cancer at diagnosis in Midwestern states independent of the distance they lived from their primary care physician and the socioeconomic status of their residential census tract. Rural women's greater odds of stage IV cancer at diagnosis could affect treatment options and mortality. Further investigation is needed into reasons for these findings.
Optimizing curative management of hepatocellular carcinoma
Authors: Nahon Pierre , Vibert Eric , Nault Jean‐Charles , Ganne‐Carrié Nathalie , Ziol Marianne , Seror Olivier 
Published: February 2020

AbstractThe goal of curative management of hepatocellular carcinoma is to provide the best chance of remission. However, recurrence rates for both local and distant relapse are high. Patient subgroups at higher risk of these events can be identified based on histological patterns that are closely linked to specific molecular subtypes. Patient outcome has improved with more effective therapeutic strategies thanks to technological advances in surgical techniques and percutaneous ablation. The main goal of controlling the cause of liver disease is to decrease distant/late recurrence and prevent deterioration of hepatic function. Ongoing trials testing the combination of neoadjuvant and/or adjuvant regimens with these procedures as well as routine tumour molecular analysis may modify therapeutic algorithms for hepatocellular carcinoma in the future.
Liver transplantation as therapy for hepatocellular carcinoma
Authors: Kim Brian , Kahn Jeffrey , Terrault Norah A. 
Published: February 2020

AbstractLiver transplantation can provide curative therapy in selected patients with hepatocellular carcinoma. Well‐established criteria include tumours that are within the Milan criteria and without evidence of vascular or extrahepatic involvement. Modest expansion of the original Milan criteria has been shown to achieve similar recurrence‐free survival rates. Overall, HCC recurrence occurs in about 10%‐15% of LT recipients, most within the first 2 years. Predictors of post‐transplant recurrence include high alpha‐foetoprotein, macrovascular invasion, as well as tumour size and number. Once HCC recurs after transplantation, prognosis is poor, though better if detected early. There is no established role for systemic prophylactic post‐transplant chemotherapy.
Hepatitis E, what’s the real issue?
Authors: Larrue Hélène , Abravanel Florence , Péron Jean‐Marie 
Published: February 2020

AbstractHepatitis E Virus (HEV) infection is a worldwide disease and the primary cause of acute viral hepatitis in the world with an estimated 20 million cases every year and 70 000 deaths. Hepatitis E is a waterborne infection in the developing countries. In these countries, HEV genotypes 1 and 2 cause large outbreaks and affect young subjects, resulting in significant mortality in pregnant women and patients with cirrhosis. In the developed countries, HEV genotypes 3 and 4 are responsible for autochthonous, sporadic hepatitis and transmission is zoonotic. Parenteral transmission by the transfusion of blood products has been identified as a potential new mode of transmission. The prevalence of positive HEV viraemia in blood donors in Europe ranges from 1/600 to 1/2500 in highly endemic European countries. HEV can cause neurological disorders and chronic infections in immunocompromised patients. The progression of acute hepatitis E is usually asymptomatic and resolves spontaneously. Diagnostic tools include anti‐HEV IgM antibodies in serum and/or viral RNA detection in the blood or the stools by PCR. Ribavirin is used to treat chronic infection. A vaccine has been developed in China.
New drugs for non‐alcoholic steatohepatitis
Authors: Cardoso Ana‐Carolina , de Figueiredo‐Mendes Claudio , A. Villela‐Nogueira Cristiane , Sanyal Arun J. 
Published: February 2020

AbstractNon‐alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in Western countries. At present the safest and most effective first‐line therapy for the management of non‐alcoholic steatohepatitis (NASH) is lifestyle modification with diet and exercise. However, long‐term adherence to lifestyle modification is rare in the target population, leading to progression of liver disease and its complications such as cirrhosis and hepatocellular carcinoma. Thus, new drugs that focus mainly on the pathogenesis of NASH to target inflammation and fibrogenesis are under investigation. This mini‐review summarizes the results of pivotal finalized phase 2 studies, and provide an outline of ongoing phase 2 and phase 3 studies.