bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of food transfers in wild golden lion tamarins (Leontopithecus rosalia): Support for the informational and nutritional hypothesis
Authors: Troisi Camille A. , Hoppitt William J. E. , Ruiz-Miranda Carlos R. , Laland Kevin N. 
Published: June 2020

AbstractCallitrichidae is a unique primate family not only in terms of the large number of food transfers to infants but also for the prevalence of transfers that are initiated by the adults. It has been hypothesized that, as well as provisioning infants, callitrichid food transfers might function to teach the receiver what food types to eat. If food provisioning has a teaching function, we would expect successful food transfers to be more likely with food types that are novel to the juveniles. We would also expect juveniles to learn about foods from those transfers. We introduced different types of food (some familiar, some novel) to wild groups of golden lion tamarins (Leontopithecus rosalia). While novel foods were not more successfully transferred than familiar food in the experiment, transfers were more successful (i.e., the receiver obtained food) when the donor had previous experience with that food. Moreover, we found evidence suggesting that food transfers influenced the future foraging choices of juveniles. Our findings are consistent with the first and third criteria of the functional definition of teaching, which requires that tutors (the adults) modify their behavior in the presence of a naïve individual (a juvenile), and that the naïve individual learns from the modified behavior of the demonstrator. Our findings are also consistent with the provisioning function of food transfer. Social learning seems to play an important role in the development of young tamarins’ foraging preferences.
Chronic kidney disease of unknown origin is associated with environmental urbanisation in Belfast, UK
Authors: McKinley Jennifer M. , Mueller Ute , Atkinson Peter M. , Ofterdinger Ulrich , Cox Siobhan F. , Doherty Rory , Fogarty Damian , Egozcue J. J. , Pawlowsky-Glahn V. 
Published: June 2020

AbstractChronic kidney disease (CKD), a collective term for many causes of progressive renal failure, is increasing worldwide due to ageing, obesity and diabetes. However, these factors cannot explain the many environmental clusters of renal disease that are known to occur globally. This study uses data from the UK Renal Registry (UKRR) including CKD of uncertain aetiology (CKDu) to investigate environmental factors in Belfast, UK. Urbanisation has been reported to have an increasing impact on soils. Using an urban soil geochemistry database of elemental concentrations of potentially toxic elements (PTEs), we investigated the association of the standardised incidence rates (SIRs) of both CKD and CKD of uncertain aetiology (CKDu) with environmental factors (PTEs), controlling for social deprivation. A compositional data analysis approach was used through balances (a special class of log contrasts) to identify elemental balances associated with CKDu. A statistically significant relationship was observed between CKD with the social deprivation measures of employment, income and education (significance levels of 0.001, 0.01 and 0.001, respectively), which have been used as a proxy for socio-economic factors such as smoking. Using three alternative regression methods (linear, generalised linear and Tweedie models), the elemental balances of Cr/Ni and As/Mo were found to produce the largest correlation with CKDu. Geogenic and atmospheric pollution deposition, traffic and brake wear emissions have been cited as sources for these PTEs which have been linked to kidney damage. This research, thus, sheds light on the increasing global burden of CKD and, in particular, the environmental and anthropogenic factors that may be linked to CKDu, particularly environmental PTEs linked to urbanisation.
Mental Health Outcomes of an Applied Game for Children with Elevated Anxiety Symptoms: A Randomized Controlled Non-inferiority Trial
Authors: Schoneveld Elke A. , Wols Aniek , Lichtwarck-Aschoff Anna , Otten Roy , Granic Isabela 
Published: June 2020

AbstractAnxiety disorders are the most prevalent mental health problems in childhood. Engaging, adequate, and appropriate prevention programs are needed. Applied games form a potential alternative delivery model and recent evidence suggests that they could be effective. The present randomized controlled non-inferiority trial investigated the beneficial effects of the applied game MindLight compared to cognitive behavioral therapy (CBT) on mental health outcomes associated with anxiety symptoms: internalizing problems, externalizing problems, and self-efficacy. In addition, we examined who benefitted most from both programs and analyzed baseline levels of anxiety, maternal mental health problems, and self-efficacy as predictors of changes in anxiety symptoms. After being screened for elevated anxiety, 174 selected children (8–12-year-old) were randomized to play MindLight or to receive a prevention program based on CBT. Study variables were assessed before and after the intervention, and at 3- and 6-months follow-up. Intention-to-treat analyses showed a significant reduction in mother-reported internalizing and externalizing problems and an increase in self-efficacy. Importantly, the magnitude of change did not differ between intervention groups. Non-inferiority analyses showed that MindLight was as effective as CBT in affecting internalizing problems and self-efficacy. However, CBT was more effective in decreasing externalizing symptoms than MindLight. Furthermore, baseline anxiety levels, maternal mental health problems, and self-efficacy did not influence the change of anxiety symptoms over time. Applied games, specifically theory-based games such as MindLight, hold potential as effective interventions for not only targeting anxiety symptoms, but also more general mental health outcomes.
New synthesis route of highly porous InxCo4Sb12 with strongly reduced thermal conductivity
Authors: Gostkowska-Lekner N. , Trawinski B. , Kosonowski A. , Bochentyn B. , Lapinski M. , Miruszewski T. , Wojciechowski K. , Kusz B. 
Published: June 2020

Abstract
Highly porous, In-filled CoSb3 skutterudite materials with an attractive thermoelectric figure of merit (ZT ~ 1) and corresponding dense samples were fabricated through the cost-effective method of reduction in oxides in dry hydrogen and the pulsed electric current sintering (PECS) method, respectively. The reduction process was described in detail using in situ thermogravimetric analysis of Co2O3, Sb2O3 and In(NO3)3·5H2O separately and in a mixture. Two methods to synthesise the same material were examined: (a) free sintering of an initially reduced powder and (b) PECS. The free-sintered materials with higher porosities (up to ~ 40%) exhibited lower values of electrical conductivity than the dense PECS samples (porosity up to ~ 5%), but the benefit of an even sixfold reduction in thermal conductivity resulted in higher ZT values. The theoretical values of thermal conductivity for various effective media models considering randomly oriented spheroid pores are in good agreement with the experimental thermal conductivity data. The assumed distribution and shape of the pores correlated well with the scanning electron microscope analysis of the microstructure. The lowest value of thermal conductivity, equal to 0.5 W/m K, was measured at 523 K for In0.1Co4Sb12 with 41% porosity. The highest value of ZTmax = 1.0 at 673 K was found for the In0.2Co4Sb12 sample in which the porosity was 36%.

Graphic abstract
The Image of Disease in Religious, Medical–Astrological and Social Discourses: Old Polish Literature as an Example of Early Modern European Mentality
Authors: Krzysztofik Małgorzata 
Published: June 2020

AbstractToday, the world is struggling with a coronavirus epidemic. People explain differently the causes and sense of this disease. Old Polish literature about diseases is representative for European thought in the modern era. The problem of the disease appears in old Polish literature in various discourses. The three most important are religious, medical–astrological and social discourse. In this article, I discuss basic paradigms of thinking connected with these discourses and the relationship between them. In the religious discourse, it is God who decides about health and illness. The pathological state of the organism can be both a trial and a punishment for the sinner. The medical and astrological discourse is based on ancient medicine, medieval medicine and astrology. It assumes a close dependence of human health on the balance of the fluids in the body and on the planetary system. The social discourse is dominated by epidemics of infectious diseases. It is a collection of advices for organizing a society during a pandemic.
Complexes of marked graphs in gauge theory
Authors: Berghoff Marko , Knispel Andre 
Published: June 2020

AbstractWe review the gauge and ghost cyle graph complexes as defined by Kreimer, Sars and van Suijlekom in “Quantization of gauge fields, graph polynomials and graph homology” and compute their cohomology. These complexes are generated by labelings on the edges or cycles of graphs and the differentials act by exchanging these labels. We show that both cases are instances of a more general construction of double complexes associated with graphs. Furthermore, we describe a universal model for these kinds of complexes which allows to treat all of them in a unified way.
Dreidimensionale Planung und Verwendung patientenspezifischer Instrumentierung (PSI) in der Schultertotalendoprothetik
Authors: Schmalzl J. , Gerhardt C. , Lehmann L. J. 
Published: June 2020

ZusammenfassungEine dreidimensionale (3D-)Darstellung des Glenoids ermöglicht durch das verbesserte Verständnis der pathologischen Glenoidmorphologie im Hinblick auf Version und Neigung eine genauere Planung und eine optimalere Positionierung der Glenoidkomponente. Die Glenoidkomponente bleibt die häufigste Ursache des späten Versagens nach anatomischer Schultertotalendoprothetik. Mögliche Gründe für eine Fehlpositionierung der Glenoidkomponente sind eine ungenaue Einschätzung der pathologischen Anatomie des Glenoids, falsche Wahl und/oder inkorrekte Positionierung des Implantats und mangelhafte chirurgische Ausführung der präoperativen Planung. Aufgrund der Einschränkungen von Standardröntgenbildern verwenden viele Chirurgen zweidimensionale(2D)-CT-Scans zur Bewertung der Glenoidmorphologie und -version. Mehrere Studien haben jedoch gezeigt, dass 3D-CT-Rekonstruktionen für den Chirurgen die Anatomie genauer und zuverlässiger darstellen als 2D-Scans – insbesondere in Fällen ausgeprägter ossärer Defektsituationen. Mithilfe von 3D-Planungen kann der Chirurg das zu verwendende Implantat auswählen und die optimale Platzierung festlegen, um den pathologischen Zustand zu korrigieren bzw. das Implantat zu fixieren. Wir beschreiben die für die 3D-Planung verfügbaren Planungssysteme, die Planungsprinzipien und die Vorgehensweise.
Artemlavanins A and B from Artemisia lavandulaefolia and Their Cytotoxicity Against Hepatic Stellate Cell Line LX2
Authors: Shen Cheng , Huang Xiao-Yan , Geng Chang-An , Li Tian-Ze , Tang Shuang , Su Li-Hua , Gao Zhen , Zhang Xue-Mei , Hu Jing , Chen Ji-Jun 
Published: June 2020

Abstract
Two new sesquiterpenoids, artemlavanins A (1) and B (3), together with fifteen known compounds (2 and 4−17) were isolated from the EtOH extract of Artemisia lavandulaefolia. The structures of new compounds were elucidated by extensive spectroscopic analyses (HRESIMS, 1D and 2D NMR) and ECD calculations. Compound 1 was a sesquiterpenoid lactone possessing a rearranged eudesmane skeleton; compounds 2–5, 6–8, 9 and 10–12 belonged to the eudesmane, guaiane, oppositane and farnesane sesquiterpenoids, respectively; compounds 13–17 were the phenyl derivatives with a 4-hydroxyacetophenone moiety. Twelve compounds (1–3, 5–7, 10–12, 14, 15 and 17) displayed cytotoxicity against hepatic stellate cell line LX2 (HSC-LX2) with IC50 values ranging from 35.1 to 370.3 μM. Compounds 2, 7, 10–12 and 17 exhibited the stronger cytotoxicity than silybin (IC50, 169.6 μM) with IC50 values of 82.1, 35.1, 95.0, 83.8, 81.6 and 90.1 μM. Compound 7 as the most active one showed significant inhibition on the deposition of human collagen type I (Col I), human hyaluronic acid (HA) and human laminin (HL) with IC50 values of 10.7, 24.5 and 13.3 μM.

Graphic Abstract
Numerical investigation on rigid and flexible pipelines embedded in granular and self-compacting materials
Authors: Abdel-Rahman Khalid , Gerlach Tim , Achmus Martin 
Published: June 2020

AbstractSelf-compacting filling material or controlled low-strength material (CLSM) is a cementitious material which is liquid during filling, and it is used primarily as backfill, e.g., in trenches. Several products are currently used as CLSM such as flowable fill, controlled density fill, flowable mortar and low-strength plastic soil–cement. The low-strength requirement is necessary to allow for future excavation of CLSM. A two-dimensional numerical model was developed using the finite element system ABAQUS. In this model, the material behavior of granular soil and CLSM is described using an elasto-plastic constitutive model with Mohr–Coulomb failure criterion. Rigid and flexible pipes were modeled once embedded in sandy soil and once embedded in self-compacting material. The numerical model allows the modeling of the effect of hardening process on the overall behavior of the pipe–soil system. The main objective of this study is to investigate the behavior of rigid and flexible pipelines embedded in CLSM as a filling material numerically and to show advantages and disadvantages in comparison with the presently widely used filling materials like sand.
Minimum quality standards and benchmarking in differentiated duopoly
Authors: Michaelis Peter , Ziesemer Thomas 
Published: June 2020

AbstractWe study a two-period model of a duopoly with goods differentiated by quality. The periods’ length corresponds to the goods’ useful lifespan, and consumers are heterogeneous in their valuation of quality. In the second period, the regulator fixes a minimum quality standard based either on the quality supplied by the high-quality firm in the first period (strict regulation) or on the average quality supplied in the first period (average regulation). Assuming a covered market, we show that such an approach leads to decreasing qualities in the first period, and increasing qualities in the second one. In both periods, net utility aggregated over consumers is increasing and profits aggregated over firms are decreasing. Taken together, average regulation always leads to an increase in the present value of welfare, whereas strict regulation can cause a decline. If the discount factor exceeds a certain threshold, a policy based on average regulation is even superior to implementing the optimal minimum quality standard already in the first period.
Cognitive Behavioral Sex Therapy: An Emerging Treatment Option for Nonorganic Erectile Dysfunction in Young Men: A Feasibility Pilot Study
Authors: Bilal Ahmad , Abbasi Najam ul Hasan 
Published: June 2020

Abstract

Introduction
An increasing number of young men have been found to develop nonorganic erectile dysfunction (NOED) in recent years. The NOED has been shown to respond better to cognitive behavior sex therapy (CBST) in a few past studies.

Aim
The present research aims to establish the efficacy of CBST as a promising treatment option in young men suffering from NOED by administering a feasibility pilot trial.

Methods
28 young men (M = 31 years) out of a total of 39 men (7 excluded, 4 quit treatment) diagnosed with NOED from sexual health clinics in Pakistan were recruited to receive CBST treatment (n = 13) on average twice a week for a period of 50 minutes per session for a period of 4, 6, 8, and 12 weeks for the mild, mild to moderate, moderate, and severe forms of NOED, respectively, and sildenafil citrate group (n = 15) receiving sildenafil citrate 50 mg on demand. The trial design was sequential random assignment clinical trial.

Main Outcome Measures
International Index of Erectile Functoning-5 and Depression Anxiety Stress Scale-21 were used before treatment, after treatment, and in follow-up as the main outcome measures.

Results
The repeated measures analysis of covariance established a nonsignificant difference between CBST and sildenafil citrate 50 mg in NOED scores improvement, NOED severity reduction, and reduction in depression scores at posttreatment assessment. There were significant differences among different CBST modalities in improving NOED scores, reduction in NOED severity, and depression scores. There was significant difference in CBST and sildenafil citrate 50 mg in anxiety reduction at posttreatment assessment. The covariates age, age groups, and NOED duration did not significantly impact the treatment outcome for both treatment groups except age which impacted the interaction of treatment and anxiety scores.

Conclusion
The CBST is an emerging and promising treatment choice in younger men suffering from NOED.
Exploring Pain-Related Anxiety and Depression in Female Patients With Provoked Vulvodynia With Associated Overactive Pelvic Floor Muscle Dysfunction
Authors: Govind Vaishnavi , Krapf Jill M. , Mitchell Leia , Barela Karissa , Tolson Hillary , Casey Jaqueline , Goldstein Andrew T. 
Published: June 2020

AbstractIntroductionVulvodynia is a chronic pain condition with potential associated factors, including musculoskeletal and psychosocial components.AimThis study explores the prevalence of pain-related anxiety and depression in women with provoked vestibulodynia with associated overactive pelvic floor muscle dysfunction (PVD-PFD).MethodsA retrospective chart review of 352 women presenting to 2 urban vulvovaginal specialty clinics over the course of a year was conducted. Women presenting for initial evaluation completed validated questionnaires for pain-related anxiety and depression. Women who completed these questionnaires with a diagnosis of PVD-PFD independently confirmed by a women’s health physical therapist were included in analysis. Information on previously attempted treatments was gathered.Main Outcome MeasuresPain-related anxiety was measured with the Pain Anxiety Symptoms Scale-20 and depression with the Patient Health Questionnaire 8.ResultsOf 79 women with confirmed PVD-PFD, 22% met criteria for pain-related anxiety alone, 4% for depression alone, and 27% for both pain-related anxiety and depression, with a significant association between anxiety and depression (χ2 (1) = 21.44, P &lt; .0005, phi = 0.521). There was also a significant association between anxiety and/or depression and whether prior treatment was attempted (χ2 (2) = 6.81, P = .03, phi = 0.294).ConclusionThe study found that 49% of women with PVD-PFD experienced pain-related anxiety, with or without depression. In addition, there was a statistically significant association between attempts at prior treatment and greater pain-related anxiety and depression. This is the first study to report a rate of pain-related anxiety specifically in women with PVD-PFD. These findings are consistent with studies showing elevated pain-related anxiety in other chronic musculoskeletal conditions, including lower back pain and fibromyalgia.
SuccSite: Incorporating Amino Acid Composition and Informative k-Spaced Amino Acid Pairs to Identify Protein Succinylation Sites
Authors: Kao Hui-Ju , Nguyen Van-Nui , Huang Kai-Yao , Chang Wen-Chi , Lee Tzong-Yi 
Published: June 2020

Abstract
Protein succinylation is a biochemical reaction in which a succinyl group (-CO-CH2-CH2-CO-) is attached to the lysine residue of a protein molecule. Lysine succinylation plays important regulatory roles in living cells. However, studies in this field are limited by the difficulty in experimentally identifying the substrate site specificity of lysine succinylation. To facilitate this process, several tools have been proposed for the computational identification of succinylated lysine sites. In this study, we developed an approach to investigate the substrate specificity of lysine succinylated sites based on amino acid composition. Using experimentally verified lysine succinylated sites collected from public resources, the significant differences in position-specific amino acid composition between succinylated and non-succinylated sites were represented using the Two Sample Logo program. These findings enabled the adoption of an effective machine learning method, support vector machine, to train a predictive model with not only the amino acid composition, but also the composition of k-spaced amino acid pairs. After the selection of the best model using a ten-fold cross-validation approach, the selected model significantly outperformed existing tools based on an independent dataset manually extracted from published research articles. Finally, the selected model was used to develop a web-based tool, SuccSite, to aid the study of protein succinylation. Two proteins were used as case studies on the website to demonstrate the effective prediction of succinylation sites. We will regularly update SuccSite by integrating more experimental datasets. SuccSite is freely accessible at http://csb.cse.yzu.edu.tw/SuccSite/.
Physical and biological properties of early winter Antarctic sea ice in the Ross Sea
Authors: Tison Jean-Louis , Maksym Ted , Fraser Alexander D. , Corkill Matthew , Kimura Noriaki , Nosaka Yuichi , Nomura Daiki , Vancoppenolle Martin , Ackley Steve , Stammerjohn Sharon , Wauthy Sarah , Van der Linden Fanny , Carnat Gauthier , Sapart Célia , de Jong Jeroen , Fripiat François , Delille Bruno 
Published: June 2020

AbstractThis work presents the results of physical and biological investigations at 27 biogeochemical stations of early winter sea ice in the Ross Sea during the 2017 PIPERS cruise. Only two similar cruises occurred in the past, in 1995 and 1998. The year 2017 was a specific year, in that ice growth in the Central Ross Sea was considerably delayed, compared to previous years. These conditions resulted in lower ice thicknesses and Chl-aburdens, as compared to those observed during the previous cruises. It also resulted in a different structure of the sympagic algal community, unusually dominated byPhaeocystisrather than diatoms. Compared to autumn-winter sea ice in the Weddell Sea (AWECS cruise), the 2017 Ross Sea pack ice displayed similar thickness distribution, but much lower snow cover and therefore nearly no flooding conditions. It is shown that contrasted dynamics of autumnal-winter sea-ice growth between the Weddell Sea and the Ross Sea impacted the development of the sympagic community. Mean/median ice Chl-aconcentrations were 3–5 times lower at PIPERS, and the community status there appeared to be more mature (decaying?), based on Phaeopigments/Chl-aratios. These contrasts are discussed in the light of temporal and spatial differences between the two cruises.
Inscrutability and Its Discontents
Authors: Schroeter Laura , Schroeter François 
Published: June 2020

AbstractOur main focus in this paper is Herman Cappelen’s claim, defended inFixing Language, that reference is radically inscrutable. We argue that Cappelen’s inscrutability thesis should be rejected. We also highlight how rejecting inscrutability undermines Cappelen’s most radical conclusions about conceptual engineering. In addition, we raise a worry about his positive account of topic continuity through inquiry and debate.