bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solvent Impact on the Properties of Benchmark Metal–Organic Frameworks: Acetonitrile‐Based Synthesis of CAU‐10, Ce‐UiO‐66, and Al‐MIL‐53
Authors: Leubner Sebastian , Stäglich Robert , Franke Julia , Jacobsen Jannick , Gosch Jonas , Siegel Renée , Reinsch Helge , Maurin Guillaume , Senker Jürgen , Yot Pascal G. , Stock Norbert 
Published: January 2020

AbstractHerein is reported the utilization of acetonitrile as a new solvent for the synthesis of the three significantly different benchmark metal–organic frameworks (MOFs) CAU‐10, Ce‐UiO‐66, and Al‐MIL‐53 of idealized composition [Al(OH)(ISO)], [Ce6O4(OH)4(BDC)6], and [Al(OH)(BDC)], respectively (ISO2−: isophthalate, BDC2−: terephthalate). Its use allowed the synthesis of Ce‐UiO‐66 on a gram scale. While CAU‐10 and Ce‐UiO‐66 exhibit properties similar to those reported elsewhere for these two materials, the obtained Al‐MIL‐53 shows no structural flexibility upon adsorption of hydrophilic or hydrophobic guest molecules such as water and xenon and is stabilized in its large‐pore form over a broad temperature range (130–450 K). The stabilization of the large‐pore form of Al‐MIL‐53 was attributed to a high percentage of noncoordinating −COOH groups as determined by solid‐state NMR spectroscopy. The defective material shows an unusually high water uptake of 310 mg g−1within the range of 0.45 to 0.65 p/p°. In spite of showing no breathing effect upon water adsorption it exhibits distinct mechanical properties. Thus, mercury intrusion porosimetry studies revealed that the solid can be reversibly forced to breathe by applying moderate pressures (≈60 MPa).
Shape Tailoring of Iodine‐Based Cesium Lead Halide Perovskite Nanocrystals in Hot‐Injection Methods
Authors: Grisorio Roberto , Fanizza Elisabetta , Striccoli Marinella , Altamura Davide , Giannini Cinzia , Allegretta Ignazio , Terzano Roberto , Suranna Gian Paolo 
Published: January 2020

AbstractAll‐inorganic lead‐halide perovskite nanocrystals continue to attract the attention of the scientific community due to their optical potential. In this work, we demonstrate that synthetic approaches based on the modulation of the ligand‐to‐metal ratio in hot‐injection methods can provide direct access to a variety of colloidal nanocrystal morphologies without resorting to post‐synthetic transformations. The shape tailoring observed for iodine‐based perovskite nanocrystals suggests that nanowires can evolve through the oriented attachment of nanocubes in the presence of high ligand‐to‐metal ratios. Conversely, mixed‐halide perovskite nanoplatelets are generated in low‐surfactant regimes, due to the peculiar reactivity of halo‐plumbate species generated before cesium injection, which favors an anisotropic growth of the nanoparticles. These results contribute to deepen the knowledge on the shape evolution of perovskite nanoparticles, thus opening the way to the development of new synthetic approaches.
Latest Trends in Temperature Sensing by Molecular Probes
Authors: Ogle Meredith M. , Smith McWilliams Ashleigh D. , Jiang Bo , Martí Angel A. 
Published: January 2020

AbstractIn this Review, we summarize the work in the last ten years on the development of fluorescent molecular probes with possible applications in microscopic thermometry. We discuss four principal types of temperature‐dependent photoluminescence features: 1) Emission intensity; 2) Ratio of emission intensities; 3) Emission peak shift; and 4) Emission lifetime. We compare the advantages, limitations, and challenges of the different probes using these types of sensing mechanisms. By focusing on molecular probes, rather than nanoparticles or polymers, the mechanisms of temperature dependence are discussed thoroughly, with the most common including twisted intramolecular charge transfer (TICT), aggregation‐induced emission (AIE), and mechanically induced change in emission (MICE). With many different confounding variables associated with each experimental method and mechanism of temperature‐dependent photoluminescence, lanthanide and transition metal complexes seem to be promising candidates for future microscopic thermometry applications.
The evolutionary advantage of fitness‐dependent recombination in diploids: A deterministic mutation–selection balance model
Authors: Rybnikov Sviatoslav , Frenkel Zeev , Korol Abraham B. 
Published: January 2020

AbstractRecombination's omnipresence in nature is one of the most intriguing problems in evolutionary biology. The question of why recombination exhibits certain general features is no less interesting than that of why it exists at all. One such feature is recombination's fitness dependence (FD). The so far developed population genetics models have focused on the evolution of FD recombination mainly in haploids, although the empirical evidence for this phenomenon comes mostly from diploids. Using numerical analysis of modifier models for infinite panmictic populations, we show here that FD recombination can be evolutionarily advantageous in diploids subjected to purifying selection. We ascribe this advantage to the differential rate of disruption of lower‐ versus higher‐fitness genotypes, which can be manifested in selected systems with at least three loci. We also show that if the modifier is linked to such selected system, it can additionally benefit from modifying this linkage in a fitness‐dependent manner. The revealed evolutionary advantage of FD recombination appeared robust to crossover interference within the selected system, either positive or negative. Remarkably, FD recombination was often favored in situations where any constant nonzero recombination was evolutionarily disfavored, implying a relaxation of the rather strict constraints on major parameters (e.g., selection intensity and epistasis) required for the evolutionary advantage of nonzero recombination formulated by classical models.
Inferior vena cava ultrasound in acute decompensated heart failure: design rationale of the CAVA‐ADHF‐DZHK10 trial
Authors: Jobs Alexander , Vonthein Reinhard , König Inke R. , Schäfer Jane , Nauck Matthias , Haag Svenja , Fichera Carlo Federico , Stiermaier Thomas , Ledwoch Jakob , Schneider Alisa , Valentova Miroslava , von Haehling Stephan , Störk Stefan , Westermann Dirk , Lenz Tobias , Arnold Natalie , Edelmann Frank , Seppelt Philipp , Felix Stephan , Lutz Matthias , Hedwig Felix , Borggrefe Martin , Scherer Clemens , Desch Steffen , Thiele Holger 
Published: January 2020

AbstractAimsTreating patients with acute decompensated heart failure (ADHF) presenting with volume overload is a common task. However, optimal guidance of decongesting therapy and treatment targets are not well defined. The inferior vena cava (IVC) diameter and its collapsibility can be used to estimate right atrial pressure, which is a measure of right‐sided haemodynamic congestion. The CAVA‐ADHF‐DZHK10 trial is designed to test the hypothesis that ultrasound assessment of the IVC in addition to clinical assessment improves decongestion as compared with clinical assessment alone.Methods and resultsCAVA‐ADHF‐DZHK10 is a randomized, controlled, patient‐blinded, multicentre, parallel‐group trial randomly assigning 388 patients with ADHF to either decongesting therapy guided by ultrasound assessment of the IVC in addition to clinical assessment or clinical assessment alone. IVC ultrasound will be performed daily between baseline and hospital discharge in all patients. However, ultrasound results will only be reported to treating physicians in the intervention group. Treatment target is relief of congestion‐related signs and symptoms in both groups with the additional goal to reduce the IVC diameter ≤21 mm and increase IVC collapsibility >50% in the intervention group. The primary endpoint is change in N‐terminal pro‐brain natriuretic peptide from baseline to hospital discharge. Secondary endpoints evaluate feasibility, efficacy of decongestion on other scales, and the impact of the intervention on clinical endpoints.ConclusionsCAVA‐ADHF‐DZHK10 will investigate whether IVC ultrasound supplementing clinical assessment improves decongestion in patients admitted for ADHF.
Right‐wing authoritarianism and majority members’ preferences for minority acculturation
Authors: Haase Anna , Asbrock Frank , Rohmann Anette 
Published: January 2020

AbstractThe present research examines the role of right‐wing authoritarianism for the formation of majority members’ attitudes towards minority members’ contribution to the acculturation process. Previous research has confirmed the link between right‐wing authoritarianism and majority members’ acculturation preferences. Nonetheless, a test of their longitudinal relationship was still lacking. Using data from a 3‐wave panel study in Germany, we demonstrate that right‐wing authoritarianism among majority members predicts less support for immigrants’ cultural maintenance and less support for the establishment of intergroup relations over time (Study 1, N = 551). Using cross‐sectional survey data, we show that collective threat mediates these relationships (Study 2, N = 817). Data were representative of the German adult population. Our findings indicate that authoritarian majority members oppose integration because they perceive foreigners as threatening. Right‐wing authoritarianism appears to be a meaningful individual difference variable linked to majority members’ attitudes towards immigrants’ maintenance of their heritage culture and the establishment of intergroup relations over time. Our findings complement recent theorizing about acculturation processes.
Ultra‐sensitive Voltammetric Aluminum Determination on a Solid Bismuth Electrode for Water Filter Verification
Authors: Kopeć Justyna , Wójcik Szymon , Jakubowska Małgorzata 
Published: January 2020

AbstractThis work presents a new ultra‐sensitive method of Al(III) as Al‐cupferron complex voltammetric determination, in 0.04 M ammonium sulfate of pH=6.1 and 0.003 M cupferron by environmentally friendly and durable Bismuth Bulk Annular Band Electrode (BiABE). The optimal measuring parameters include: potential window from −700 to −1250 mV versus Ag|AgCl, preconcentration time and potential of 120 s, −700 mV, respectively. The electrode surface can be activated by fast in situ method: applying short conditioning by the potential of −1300 mV. The best obtained analytical parameters are: range of linearity 0.2–1.2 μg L−1 with high sensitivity of 1.333 μA/μg L−1, limit of detection 0.04 μg L−1 and repeatability below 2.3 %. The described procedure was verified using various CRMs, i. e. surface waters, waste waters and tea leaves. Satisfactory recovery values were obtained in the interval 99.2–103.5 %. Developed DPV procedure was used to determine Al in tap and natural waters in aspect of recovery of aluminum, which was added to the samples. For the first time, we tested also Al removal efficiency from water by the water filters mounted in the trip bottle.
Oil refining in Sicily: A critical perspective looking to the future
Authors: Pagliaro Mario , Meneguzzo Francesco 
Published: January 2020

AbstractHosting close to half of Italy's oil refining capacity, Sicily is home to four petroleum refineries, one of which ended operations in 2014‐2015. Following an updated outlook of Sicily's oil infrastructure, this study provides both a critical perspective as to where oil refining in Sicily currently stands and a substantial view into its near future. We conclude offering a clue on how the autonomous Sicily's government might act to face the consequences of the undergoing profound changes summarized herein.
Latency‐minimum offloading decision and resource allocation for fog‐enabled Internet of Things networks
Authors: Wang Qian , Chen Siguang 
Published: January 2020

AbstractThe rapid growth of the number of sensing devices enables computation offloading to be a promising solution to alleviate the burden of core network communication and provide low delay services, especially for those computation‐intensive and delay‐sensitive tasks. For meeting the processing requirements of these tasks sufficiently, a latency‐minimum offloading decision and resource allocation scheme for fog‐enabled Internet of Things (IoT) networks is developed in this article. Specifically, we formulate a joint optimization problem of the offloading decision, the local computation capability, and the computing resource allocation of fog node to minimize the task completion time with energy constraint, in which practically considers M/M/1 waiting queues in the wireless channel and fog node. To solve this mixed integer nonlinear programming problem with low complexity, we first calculate the optimal values of local computation capability and computing resource allocation of fog node by decomposing the original optimization problem into two independent subproblems. Subsequently, we propose a hybrid genetic simulated annealing‐based latency‐minimum offloading decision algorithm to optimize the offloading decision. Finally, the numerical results verify that our proposed scheme achieves significant advantages compared to other alternative schemes in terms of completion time and energy consumption, and they also confirm the advantage of convergence speed and quality.
Normal variations in personality predict eating behavior, oral health, and partial syndrome bulimia nervosa in adolescent girls
Authors: Allen Mark S. , Robson Davina A. , Laborde Sylvain 
Published: January 2020

AbstractEating disorders are among the most prevalent disorders in adolescence and can have negative consequences including poor quality of life, medical complications, and even death. This study addresses whether normal variations in personality relate to eating behavior and eating disorder symptomatology in adolescent girls. Participants were a near‐representative sample of Australian adolescent girls (n = 1,676). Three personality traits (neuroticism, extraversion, and conscientiousness) were assessed at age 12 and again at age 14, and self‐reported eating and weight management behaviors were assessed at age 14. After controlling for sociodemographic factors, higher levels of conscientiousness at age 12, and increases in conscientiousness between ages 12 and 14, were associated with greater fruit and vegetable consumption, a lower intake of high fat foods and high sugar drinks, less frequent meal skipping, better oral health, and decreased risk of partial syndrome bulimia nervosa at age 14. Higher neuroticism at age 12 was associated with more frequent meal skipping, and increases in neuroticism between ages 12 and 14 were associated with more frequent meal skipping and increased risk of partial syndrome bulimia nervosa at age 14. Extraversion was generally unrelated to eating and weight management behaviors. These findings provide evidence that normal variations in personality are related to eating behavior, oral health, and eating disorder symptoms during midadolescence.
Trends in head and neck fellowship graduates in the United States from 1997 to 2017
Authors: Lin Yufan , Patel Dhruv , Ramsey Tam , Gildener‐Leapman Neil 
Published: January 2020

AbstractBackgroundWe investigated whether the supply of head and neck fellowship graduates matches head and neck cancer trends.MethodsGraduates between 1997 and 2017 from the American Head and Neck Society (AHNS) and United States Otolaryngology fellowship program webpages were identified. Trends in graduates were compared with head and neck cancer incidence obtained from the Center of Disease Control.ResultsOf 538 fellows, 428 were from the United States. Of fellows practicing in the United States, 24.14% were female. Most practice locations were urban (98.44%). AHNS fellowship positions from 1997 to 2017 increased by nearly 1.82 per year (P < .00001). Graduates in academic positions increased by 1.03 per year (P < .00001). Concomitantly, the age‐adjusted incidence rate of oral, oropharyngeal, and laryngeal cancers decreased (P = .0115).ConclusionThere is important geographic variability in the practice locations of Head and Neck Oncologic Surgeons in the United States and our data may be helpful in matching clinical supply and demand.
Paired phase II trials evaluating cetuximab and radiotherapy for low risk HPV associated oropharyngeal cancer and locoregionally advanced squamous cell carcinoma of the head and neck in patients not eligible for cisplatin
Authors: Swiecicki Paul L. , Li Pin , Bellile Emily , Stucken Chaz , Malloy Kelly , Shuman Andrew , Spector Matthew E. , Chinn Steven , Casper Keith , McLean Scott , Moyer Jeffery , Chepeha Douglas , Wolf Gregory T , Prince Mark , Bradford Carol , Nyati Mukesh , Eisbruch Avraham , Worden Francis P , Jolly Shruti , Mierzwa Michelle 
Published: January 2020

AbstractBackgroundAlternative therapeutic strategies are needed for localized oropharyngeal carcinoma. Cetuximab represents a potential option for those ineligible for cisplatin or, until recently, an agent for de‐escalation in low risk HPV+ oropharyngeal carcinoma (OPSCC). Our objective was to define the toxicity and efficacy of cetuximab‐radiotherapy.MethodsWe conducted paired phase II trials evaluating cetuximab‐radiotherapy in two cohorts (a) low risk HPV+ OPSCC and (b) cisplatin ineligible. The mean follow‐up was 48 months.ResultsForty‐two patients were enrolled in cohort A with a 2‐year disease free survival (DFS) of 81%. Twenty‐one patients were enrolled in cohort B prior to closure due to adverse outcomes with a 2‐year DFS of 37%. Severe toxicities were seen in 60% of patients, 30% required enteral nutrition.ConclusionAmong cisplatin ineligible patients, cetuximab treatment engendered poor outcomes. Rates of severe toxicities were on par with platinum‐based regimens suggesting that cetuximab is not a benign treatment.
The enhancement of laminar jet cooling effectiveness at very high surface temperature by using Al2O3 nanofluid as a coolant
Authors: Barik Kashinath , Chitransh Susmit , Pati A. R. , Swain B. , Behera Ajit , Mohapatra S. S. 
Published: January 2020

AbstractIn the current study, as per the requirement of various metal quenching industries, high heat removal rate, low consumption rate of the coolant, and the minimum operating cost of the process have been tried to be achieved in the Leidenfrost region by using a nanofluid low mass flux laminar jet. In this regard, an indigenously designed and fabricated experimental setup was used and before experimentation, the coolant (Al2O3+Water) thermophysical properties variation was monitored for the mapping of the transfer characteristics during the cooling process. The thermal analysis discloses that the critical heat flux (CHF) depicts a trend with the rising nanoparticle concentration in the mixture; however, at the medium concentration (0.10% Al2O3) except the CHF region, in the remaining region, better heat removal rate is observed. The comparison of the current cooling methodology with that reported in literature clearly approves that the proposed process methodology mitigates the requirements described above.
Homogentisic acid affects human osteoblastic functionality by oxidative stress and alteration of the Wnt/β‐catenin signaling pathway
Authors: Schiavone Maria Lucia , Millucci Lia , Bernardini Giulia , Giustarini Daniela , Rossi Ranieri , Marzocchi Barbara , Santucci Annalisa 
Published: January 2020

AbstractAlkaptonuria (AKU) is a rare disease correlated with deficiency of the enzyme homogentisate 1,2 dioxygenase, which causes homogentisic acid (HGA) accumulation. HGA is subjected to oxidation/polymerization reactions, leading to the production of a peculiar melanin‐like pigmentation (ochronosis) after chronic inflammation, which is considered as a triggering event for the generation of oxidative stress. Clinical manifestations of AKU are urine darkening, sclera pigmentation, early severe osteoarthropathy, and cardiovascular and renal complication. Despite major clinical manifestations of AKU being observed in the bones and skeleton, the molecular and functional parameters are so far unknown in AKU. In the present study, we used human osteoblasts supplemented with HGA as a AKU cellular model. We observed marked oxidative stress, and for the first time, we were able to correlate HGA deposition with an impairment in the Wnt/β‐catenin signaling pathway, opening a range of possible therapeutic strategies for a disease still lacking a known cure.
Hyaluronic acid‐decorated liposomal nanoparticles for targeted delivery of 5‐fluorouracil into HT‐29 colorectal cancer cells
Authors: Mansoori Behzad , Mohammadi Ali , Abedi‐Gaballu Fereydoon , Abbaspour Soheil , Ghasabi Mehri , Yekta Reza , Shirjang Solmaz , Dehghan Gholamreza , Hamblin Michael R. , Baradaran Behzad 
Published: January 2020

AbstractThe use of liposomes as drug carriers improves the therapeutic efficacy of anticancer drugs, while at the same time reducing side effects. Hyaluronic acid (HA) is recognized by the CD44 receptor, which is overexpressed in many cancer cells. In this study, we developed HA‐modified liposomes encapsulating 5‐fluorouracil (5‐FU) and tested them against a CD44 expressing colorectal cell line (HT29) and a non‐CD44 expressing hepatoma cell line. The average size of 5‐FU‐lipo and 5‐FU‐lipo‐HA nanoparticles were 112 ± 28 and 144 ± 77 nm, respectively. The 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium (MTT) assay showed selective cancer cell death depending on the CD44 expression in a time‐dependent manner. Apoptosis assays and cell‐cycle analysis indicated that G0/G1 arrest occurred. The colony formation study revealed that cells treated with 5‐FU‐lipo and 5‐FU‐lipo‐HA had reduced colony formation. Quantitative reverse‐transcription polymerase chain reaction study showed that the oncogenic messenger RNA and microRNA levels were significantly reduced in the 5‐FU‐lipo‐HA‐treated group, while tumor suppressors were increased in that group. We suggest that optimal targeted delivery and release of 5‐FU into colorectal cancer cells, renders them susceptible to apoptosis, cell‐cycle arrest, and decreased colony formation.
Identification, expression and functional analysis of prmt7 in medaka Oryzias latipes
Authors: Li Fangqing , Zhu Huihui , Hou Mengying , Zhang Xiaoyi , Li Zhenzhen , Zhao Haobin , Zhou Qingchun , Zhong Xueping 
Published: January 2020

AbstractArginine methylation is an important posttranslational modification and catalyzed by a family of protein arginine methyltransferases (PRMTs). PRMT7 is the type III PRMT and produces solely monomethylarginine products. PRMT7 has been found to play important roles in multiple biological processes in mammals. However, the expression pattern and function of Prmt7 remain largely unknown in fish. In this study, we characterized the medaka prmt7 gene and determined its expression pattern and function during embryogenesis and germ cell development. The results showed that the chromosomal location and gene structure of medaka prmt7 were similar to its mammalian orthologs. Comparisons of deduced amino acid sequences indicated that medaka Prmt7 was a homolog of human PRMT7 with two methyltransferase domains. Reverse transcription‐polymerase chain reaction (RT‐PCR) and real time RT‐PCR revealed that medaka prmt7 had maternal origin with continuous and dynamical expression during embryonic development. Whole‐mount in situ hybridization analysis observed that the transcripts of prmt7 were ubiquitous at morula and gastrula stage, and were later riched in the brain and otic vesicles during embryogenesis. In the adult stage, prmt7 messenger RNA was detected in all examined tissues with the high levels in the ovary and testis. The expression of prmt7 in the gonads was restricted to oocytes of the ovary and spermatids/sperm of the testis. Functional analysis showed that knockdown of medaka prmt7 did not reduce the total number of primordial germ cells (PGCs) in vivo but significantly affected PGCs distribution during embryonic development. These results indicate that prmt7 may be involved in germ cell development in medaka.