bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of non-Hodgkin’s lymphoma at Felegehiwot specialized hospital, North West Ethiopia: A case-control study
Authors: Chekol Dessalegn , Bedimo Melkamu , Mulugeta Yihun , Bantie Getasew Mulat 
Published: December 2020

Background
The global burden of cancer continues to increase largely because of the aging and growth of the world population alongside an increasing adoption of cancer-causing behaviors. Hence, the purpose of this study was to identify determinants of Non-Hodgkin lymphoma cancer among individuals who diagnosed at the Felegehiwot specialized hospital, North West Ethiopia, 2019.

Methods
An institution-based unmatched case-control study was conducted at the Felegehiwot Specialized hospital from December 2018 up to June 2019. The sample size calculated using the two-population proportion formula. The final sample size was 486, (162 cases and 324 controls). The simple random sampling method was employed to catch up with the estimated samples. The collected data entered into the Epi-data version 3.1 software and analyzed using SPSS version 21 software. Descriptive statistics computed. Simple logistic analysis was run (at 95% CI and p-value < 0.05) to identify the determinants of non-Hodgkin’s lymphoma.

Result
A total of 486 patients participated. Nearly one-third of the cases and controls were in the age group of 46–60 years. About 90% of cases and 91% of controls were orthodox Christian. Monthly income of ≤28 dollars (AOR = 2. 73, 95%CI: 1. 8, 4.2), male sex (AOR = 1. 8, 95%CI: 1.2, 2.8), ever had chemical exposure, (AOR = 11. 9, 95%CI: 7.6, 18.8), no regular physical exercise (AOR = 15. 5, 95%CI: 5.7, 42.3), and having hypertension [AOR = 0. 03; 95%CI:0.005, 0.2), lung disease (AOR = 0. 2; 95%CI: 0.06, 0.7), and chronic kidney and cardiac diseases (AOR = 0. 06; 95%CI: 0.01, 0.2) were the determinants of non-Hodgkin’s lymphoma.

Conclusions
The findings in this study suggest that having a low monthly income, being male sex, ever had chemical exposure, not engaged in regular physical exercise, and being diabetic were the determinants of non-Hodgkin’s lymphoma.
Clustering fibromyalgia patients: A combination of psychosocial and somatic factors leads to resilient coping in a subgroup of fibromyalgia patients
Authors: Braun Alexandra , Evdokimov Dimitar , Frank Johanna , Pauli Paul , Üçeyler Nurcan , Sommer Claudia 
Published: December 2020

BackgroundCoping strategies and their efficacy vary greatly in patients suffering from fibromyalgia syndrome (FMS).ObjectiveWe aimed to identify somatic and psychosocial factors that might contribute to different coping strategies and resilience levels in FMS.Subjects and methodsStandardized questionnaires were used to assess coping, pain, and psychological variables in a cohort of 156 FMS patients. Quantitative real-time polymerase chain reaction (qRT-PCR) determined gene expression of selected cytokines in white blood cells of 136 FMS patients and 25 healthy controls. Data of skin innervation, functional and structural sensory profiles of peripheral nociceptive nerve fibers of a previous study were included into the statistics. An exploratory factor analysis was used to define variance explaining factors, which were then included into cluster analysis.Results54.9% of the variance was explained by four factors which we termed (1) affective load, (2) coping, (3) pain, and (4) pro-inflammatory cytokines (p < 0.05). Considering differences in the emerged factors, coping strategies, cytokine profiles, and disability levels, 118 FMS patients could be categorized into four clusters which we named “maladaptive”, “adaptive”, “vulnerable”, and “resilient” (p < 0.05). The adaptive cluster had low scores in disability and in all symptom categories in contrast to the vulnerable cluster, which was characterized by high scores in catastrophizing and disability (p < 0.05). The resilient vs. the maladaptive cluster was characterized by better coping and a less pro-inflammatory cytokine pattern (p < 0.05).ConclusionOur data suggest that problem- and emotion-focused coping strategies and an anti-inflammatory cytokine pattern are associated with reduced disability and might promote resilience. Additional personal factors such as low anxiety scores, ability of acceptance, and persistence further favor a resilient phenotype. Individualized therapy should take these factors into account.
Antibiotic prescription practices among prescribers for children under five at public health centers III and IV in Mbarara district
Authors: Okello Nelson , Oloro Joseph , Kyakwera Catherine , Kumbakumba Elias , Obua Celestino 
Published: December 2020

Introduction
Rational use of medicines requires that patients receive medications appropriate to their clinical needs. Irrational prescription of antibiotics has been reported in many health systems across the world. In Uganda, mainly nurses and assistant medical officers (Clinical officers) prescribe for children at level III and IV primary care facilities (health center II and IV). Nurses are not primarily trained prescribers; their antibiotic prescription maybe associated with errors. There is a need to understand the practices of antibiotic prescription among prescribers in the public primary care facilities. We therefore determined antibiotic prescription practices of prescribers for children under five years at health center III and IV in Mbarara district, South Western Uganda.

Methods
This was a retrospective descriptive cross-sectional study. We reviewed outpatient records of children <5 years of age retrospectively. Information obtained from the outpatient registers were captured in predesigned data abstraction form. Health care providers working at health centers III and IV were interviewed using a structured questionnaire. They provided information on socio-demographic, health facility, antibiotic prescription practices and availability of reference tools. Data was analyzed using STATA software version 13∙0.

Results
There were 1218 outpatients records of children under five years reviewed and 35 health care providers interviewed. The most common childhood illness diagnosed was upper respiratory tract infection. It received the most antibiotic prescription (53%). The most commonly prescribed oral antibiotics were cotrimoxazole and amoxicillin, and ceftriaxone and benzyl penicillin were the commonest prescribed injectable antibiotics. Up to 68.4% of the antibiotic prescription was irrational. No prescriber or facility factors were associated with irrational antibiotic prescription practices.

Conclusion
Upper respiratory tract infection is the most diagnosed condition in children under five years with Cotrimoxazole and Amoxicillin being the most commonly prescribed antibiotics. Antibiotics are being prescribed irrationally at health centers III and IV in Mbarara District. Training and support supervision of prescribers at health centers III and IV in Mbarara district need to be prioritized by the district health team.
Feasibility of non-contact cardiorespiratory monitoring using impulse-radio ultra-wideband radar in the neonatal intensive care unit
Authors: Lee Won Hyuk , Lee Yonggu , Na Jae Yoon , Kim Seung Hyun , Lee Hyun Ju , Lim Young-Hyo , Cho Seok Hyun , Cho Sung Ho , Park Hyun-Kyung 
Published: December 2020

Background
Current cardiorespiratory monitoring equipment can cause injuries and infections in neonates with fragile skin. Impulse-radio ultra-wideband (IR-UWB) radar was recently demonstrated to be an effective contactless vital sign monitor in adults. The purpose of this study was to assess heart rates (HRs) and respiratory rates (RRs) in the neonatal intensive care unit (NICU) using IR-UWB radar and to evaluate its accuracy and reliability compared to conventional electrocardiography (ECG)/impedance pneumography (IPG).

Methods
The HR and RR were recorded in 34 neonates between 3 and 72 days of age during minimal movement (51 measurements in total) using IR-UWB radar (HRRd, RRRd) and ECG/IPG (HRECG, RRIPG) simultaneously. The radar signals were processed in real time using algorithms for neonates. Radar and ECG/IPG measurements were compared using concordance correlation coefficients (CCCs) and Bland-Altman plots.

Results
From the 34 neonates, 12,530 HR samples and 3,504 RR samples were measured. Both the HR and RR measured using the two methods were highly concordant when the neonates had minimal movements (CCC = 0.95 between the RRRd and RRIPG, CCC = 0.97 between the HRRd and HRECG). In the Bland-Altman plot, the mean biases were 0.17 breaths/min (95% limit of agreement [LOA] -7.0–7.3) between the RRRd and RRIPG and -0.23 bpm (95% LOA -5.3–4.8) between the HRRd and HRECG. Moreover, the agreement for the HR and RR measurements between the two modalities was consistently high regardless of neonate weight.

Conclusions
A cardiorespiratory monitor using IR-UWB radar may provide accurate non-contact HR and RR estimates without wires and electrodes for neonates in the NICU.
High-risk pregnancies and their association with severe maternal morbidity in Nepal: A prospective cohort study
Authors: Rajbanshi Sushma , Norhayati Mohd Noor , Nik Hazlina Nik Hussain 
Published: December 2020

Background
The early identification of pregnant women at risk of developing complications at birth is fundamental to antenatal care and an important strategy in preventing maternal death. This study aimed to determine the prevalence of high-risk pregnancies and explore the association between risk stratification and severe maternal morbidity.

Methods
This hospital-based prospective cohort study included 346 pregnant women between 28–32 gestational weeks who were followed up after childbirth at Koshi Hospital in Nepal. The Malaysian antenatal risk stratification approach, which applies four color codes, was used: red and yellow denote high-risk women, while green and white indicate low-risk women based on maternal past and present medical and obstetric risk factors. The World Health Organization criteria were used to identify women with severe maternal morbidity. Multivariate confirmatory logistic regression analysis was performed to adjust for possible confounders (age and mode of birth) and explore the association between risk stratification and severe maternal morbidity.

Results
The prevalence of high-risk pregnancies was 14.4%. Based on the color-coded risk stratification, 7.5% of the women were categorized red, 6.9% yellow, 72.0% green, and 13.6% white. The women with high-risk pregnancies were 4.2 times more likely to develop severe maternal morbidity conditions during childbirth.

Conclusions
Although smaller in percentage, the chances of severe maternal morbidity among high-risk pregnancies were higher than those of low-risk pregnancies. This risk scoring approach shows the potential to predict severe maternal morbidity if routine screening is implemented at antenatal care services. Notwithstanding, unpredictable severe maternal morbidity events also occur among low-risk pregnant women, thus all pregnant women require vigilance and quality obstetrics care but high-risk pregnant women require specialized care and referral.
Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru
Authors: Mejía Fernando , Medina Carlos , Cornejo Enrique , Morello Enrique , Vásquez Sergio , Alave Jorge , Schwalb Alvaro , Málaga Germán 
Published: December 2020

Introduction
Peru is among the top ten countries with the highest number of coronavirus disease 2019 (COVID-19) cases worldwide. The aim of the study was to describe the clinical features of hospitalized adult patients with COVID-19 and to determine the prognostic factors associated with in-hospital mortality.

Methods
We conducted a retrospective cohort study among adult patients with COVID-19 admitted to Hospital Cayetano Heredia; a tertiary care hospital in Lima, Peru. The primary outcome was in-hospital mortality. Multivariate Cox proportional hazards regression was used to identify factors independently associated with in-hospital mortality.

Results
A total of 369 patients (median age 59 years [IQR:49–68]; 241 (65.31%) male) were included. Most patients (68.56%) reported at least one comorbidity; more frequently: obesity (42.55%), diabetes mellitus (21.95%), and hypertension (21.68%). The median duration of symptoms prior to hospital admission was 7 days (IQR: 5–10). Reported in-hospital mortality was 49.59%. By multiple Cox regression, oxygen saturation (SaO2) values of less than 90% on admission correlated with mortality, presenting 1.86 (95%CI: 1.02–3.39), 4.44 (95%CI: 2.46–8.02) and 7.74 (95%CI: 4.54–13.19) times greater risk of death for SaO2 of 89–85%, 84–80% and <80%, respectively, when compared to patients with SaO2 >90%. Additionally, age >60 years was associated with 1.88 times greater mortality.

Conclusions
Oxygen saturation below 90% on admission is a strong predictor of in-hospital mortality in patients with COVID-19. In settings with limited resources, efforts to reduce mortality in COVID-19 should focus on early identification of hypoxemia and timely access to hospital care.
Efficacy and safety of extracorporeal shockwave therapy for the treatment of chronic non-bacterial prostatitis: A systematic review and meta-analysis
Authors: Birowo Ponco , Rangganata Ervandy , Rasyid Nur , Atmoko Widi 
Published: December 2020

Purpose
Chronic pelvic pain syndrome (CPPS) is one of the most common outpatient urological diagnoses, and its incidence is increasing. Extracorporeal shockwave therapy (ESWT) has been suggested for relieving local perineal symptoms associated with chronic prostatitis/CPPS. Despite several treatment methods, no causal or standardized treatment is available for CPPS. This study aimed to investigate the efficacy and safety profile of ESWT for the treatment of chronic non-bacterial prostatitis.

Materials and methods
Studies were collected using four search engines (Pubmed, Cochrane, ScienceDirect, and EBSCOHost), on May 16, 2020; and assessed based on predetermined inclusion and exclusion criteria. Two reviewers performed study selection. Studies were then analyzed using Review Manager 5.3 for the meta-analysis.

Results
Seventy-four publications were initially retrieved, and three studies were considered for both qualitative and quantitative analyses. From these studies, we found that the use of ESWT was significantly associated with decreased pain domain (mean difference: -3.93; 95% confidence interval [CI] -5.13, -2.73; p<0.001), improved urinary score (mean difference: -1.79; 95% CI -2.38, -1.21; p<0.001), improved quality of life (mean difference: -1.71; 95% CI -2.12, -1.31; p<0.001), and improved National Institutes of Health chronic prostatitis symptom index (NIH-CPSI) score (mean difference: -5.45; 95% CI -5.74, -5.16; p<0.001) after 12 weeks of treatment.

Conclusion
ESWT is efficacious and safe in reducing pain and improving urinary condition, NIH-CPSI score, and quality of life in patients with chronic non-bacterial prostatitis.
A Multicenter Pilot Randomized Clinical Trial of a Home-Based Exercise Program for Patients With Cirrhosis: The Strength Training Intervention (STRIVE)
Authors: Lai Jennifer C. , Dodge Jennifer L. , Kappus Matthew R. , Wong Randi , Mohamad Yara , Segev Dorry L. , McAdams-DeMarco Mara 
Published: December 2020

INTRODUCTION
We developed the strength training intervention (STRIVE), a home-based exercise program targeting physical function in patients with cirrhosis. In this pilot study, we aimed to evaluate the safety and efficacy of STRIVE.

METHODS
Eligible were adult patients with cirrhosis at 3 sites. Patients were randomized 2:1–12 weeks of STRIVE, a 30-minute strength training video plus a health coach or standard of care (SOC). Physical function and quality of life were assessed using the Liver Frailty Index (LFI) and Chronic Liver Disease Questionnaire (CLDQ), respectively.

RESULTS
Fifty-eight and 25 were randomized to STRIVE and SOC arms, respectively: 43% women, median age was 61 years, MELDNa, Model for End-Stage Liver Disease Sodium was 14, and 54% were Child-Pugh B/C. Baseline characteristics were similar in the STRIVE vs SOC arms except for rates of hepatic encephalopathy (19 vs 36%). LFI @ 12 weeks was available in 43 STRIVE and 20 SOC participants. After 12 weeks, the median LFI improved from 3.8 to 3.6 (ΔLFI −0.1) in the STRIVE arm and 3.7 to 3.6 (ΔLFI −0.1) in the SOC arm (P = 0.65 for ΔLFI difference). CLDQ scores improved from 4.6 to 5.2 in STRIVE participants (ΔCLDQ 0.38) and did not change in SOC participants (4.2–4.2; ΔCLDQ −0.03) (P = 0.09 for ΔCLDQ difference). One patient died (SOC arm) of bleeding. Only 14% of STRIVE participants adhered to the strength training video for 10–12 weeks. No adverse events were reported by STRIVE participants.

DISCUSSION
STRIVE, a home-based structured exercise program for patients with cirrhosis, was safely administered at 3 sites, but adherence was low. Although all participants showed minimal improvement in the LFI, STRIVE was associated with a substantial improvement in quality of life.
Um Arquivo de Experiências Vividas, uma Escola de Conhecimentos:
Authors: Duarte Hadler Maria Sílvia , Pinto Junior Arnaldo 
Published: December 2020

Documentos de um arquivo podem ser utilizados por professores e estudantes dos anos iniciais do Ensino Fundamental para estudos históricos escolares? Quais são as potencialidades e os limites da escola se constituir em um espaço de produção de conhecimento? Essas e outras questões motivaram intensos debates nas últimas décadas acerca de concepções curriculares e práticas pedagógicas. A partir da problematização de tendências culturais prevalecentes na vida social que afetam as experiências vividas dos sujeitos na contemporaneidade, este artigo propõe reflexões em torno das possibilidades de se desenvolverem, no âmbito do ensino de História, práticas educacionais transformadoras relativas à utilização de documentos de arquivos por integrantes da Educação Básica. Dialogando com referenciais teórico-metodológicos da história cultural, coordenamos um projeto de extensão comunitária que contou com a participação de escolas públicas da cidade de Campinas, da Faculdade de Educação e do Centro de Memória - Unicamp (CMU). Ao trabalharmos com questões que abarcavam a história local, a memória e patrimônio cultural, observamos que as relações estabelecidas entre professores, estudantes e documentos textuais e iconográficos do CMU proporcionaram instigantes articulações com suas visões de mundo, evidenciadas pelos múltiplos modos de leitura, apropriação e produção de conhecimento. Nesse sentido, questionamos a suposta necessidade de acúmulo de informação criada pelas sociedades modernas e ressaltamos a importância das experiências vividas para a constituição de novas perspectivas de espacialidade e temporalidade, capazes de se contrapor e superar cenários compostos por diferentes formas de exclusão social, desenraizamentos culturais e de crise de identidades.
MODELING EAST JAVA INDONESIA LIFE EXPECTANCY USING SEMIPARAMETRIC REGRESSION MIXED SPLINE TRUNCATED AND FOURIER SERIES
Authors: Nisa' Khaerun , Budiantara I Nyoman 
Published: December 2020

Life expectancy is one of the indicators used to evaluate the government’s performance in improving the well-being of the population. High life expectancy in an area indicates that people in the area have been assured of health and poverty has been well overcome, and vice versa. Based on national socioeconomic survey (SUSENAS) data, showing life expectancy in East Java Province from 2009 to 2013 increased by 69.15 years to 70,19 years. Although overall life expectancy in East Java province has increased, there are still some areas that have life expectancy below 65 years. This is not from the different characteristics of each religion. Therefore, the main purpose of this study is to model life expectancy in East Java using semiparametric regression with a mixed estimator of Spline Truncated and Fourier Series. Based on the research that has been done, the results that modeling the data of life expectancy using mixed estimator of Spline Truncated and Fourier Series produced a value of R2 of 99,62% which means that the predictor variables are able to explain the response variabel life expectancy of 99.62%.
Stopping Renin-Angiotensin System Inhibitors in Patients with Advanced CKD and Risk of Adverse Outcomes: A Nationwide Study
Authors: Fu Edouard L. , Evans Marie , Clase Catherine M. , Tomlinson Laurie A. , van Diepen Merel , Dekker Friedo W. , Carrero Juan J. 
Published: December 2020

Background
It is unknown whether stopping renin-angiotensin system (RAS) inhibitor therapy in patients with advanced CKD affects outcomes.

Methods
We studied patients referred to nephrologist care, listed on the Swedish Renal Registry during 2007–2017, who developed advanced CKD (eGFR<30 ml/min per 1.73 m2) while on RAS inhibitor therapy. Using target trial emulation techniques on the basis of cloning, censoring, and weighting, we compared the risks of stopping within 6 months and remaining off treatment versus continuing RAS inhibitor therapy. These included risks of subsequent 5-year all-cause mortality, major adverse cardiovascular events, and initiation of kidney replacement therapy (KRT).

Results
Of 10,254 prevalent RAS inhibitor users (median age 72 years, 36% female) with new-onset eGFR <30 ml/min per 1.73 m2, 1553 (15%) stopped RAS inhibitor therapy within 6 months. Median eGFR was 23 ml/min per 1.73 m2. Compared with continuing RAS inhibition, stopping this therapy was associated with a higher absolute 5-year risk of death (40.9% versus 54.5%) and major adverse cardiovascular events (47.6% versus 59.5%), but with a lower risk of KRT (36.1% versus 27.9%); these corresponded to absolute risk differences of 13.6 events per 100 patients, 11.9 events per 100 patients, and −8.3 events per 100 patients, respectively. Results were consistent whether patients stopped RAS inhibition at higher or lower eGFR, across prespecified subgroups, after adjustment and stratification for albuminuria and potassium, and when modeling RAS inhibition as a time-dependent exposure using a marginal structural model.

Conclusions
In this nationwide observational study of people with advanced CKD, stopping RAS inhibition was associated with higher absolute risks of mortality and major adverse cardiovascular events, but also with a lower absolute risk of initiating KRT.
Öğrencilerin Selçuk Üniversitesi, Alaeddin Keykubad Kampüsü’ne Yönelik Suç Korkusu
Authors: ÇELİK Filiz , MİRZA Esra 
Published: December 2020

Korku, bir tehlike veya tehlike düşüncesi, tehdit, risk, kaygı ve endişe gibi uyarıcıların etkisiyle ortaya çıkan güvensizlik algısıdır. Suç, yasalara ve kurallara aykırı davranış olarak ifade edilirken; suç korkusu, bir suçun mağduru olma korkusu şeklinde ifade edilmektedir. Bireysel ve toplumsal bir olgu olan suç korkusu, mekânsal boyutta da etkilidir. Bir mekânın güvensiz algılanmasına ve korku hissine sebep olan sorunların başında yer almaktadır. Kentlerin güvensiz olduğu endişesinin giderek artmasına paralel olarak suç korkusu, bütün Dünyada yaygınlaşmaktadır. Üniversite kampüsleri de tıpkı kentler gibi güvensizlik algısına bağlı olarak suç korkusunun yaşandığı mekânsal etkilere sahiptir. Suç korkusu, bir yandan güvensizlik yaratarak kampüsteki yaşamı sınırlandırmakta diğer yandan da kampüsteki düzen, huzur ortamı, yaşam kalitesi, konfor seviyesi ve sosyal kontrolü olumsuz etkilemektedir.
Bu çalışmanın amacı, öğrencilerin Alaeddin Keykubad Kampüsü fiziksel özelliklerine ilişkin suç korkusu algılarını belirlemektir. Nitel ve nicel sorgulama yöntemine göre elde edilen veriler doğrultusunda Alaeddin Keykubad Kampüsü’nün güvensiz algılanan ve suça maruz kalma riskinin yüksek olduğu yerler belirlenmiş, kampüste öğrencilerin güvenlik algısına olumlu yönde katkı sağlayacak ve suça maruz kalma riskini azaltacak önerilere yer verilmiştir.