bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary hepatic malignant vascular tumors: a follow-up study of imaging characteristics and clinicopathological features
Authors: Zhou Yue , Hou Ping , Wang Feng , Li Bingjie , Gao Jianbo 
Published: August 2020

Abstract
Background
Owing to its low incidence, there is insufficient clinical awareness and diagnostic experience with primary hepatic malignant vascular tumors (PHMVTs). The aim of our study was to investigate the imaging and clinicopathological features of patients with PHMVTs and analyze the clinicopathological correlations.

Methods
We retrospectively analyzed 42 patients who had pathologically confirmed PHMVT during the period from June 2012 to December 2019 and enrolled them in our study. The computed tomography (CT) and magnetic resonance (MR) images and pathological findings of each patient were recorded.

Results
There were more female (29/42) than male patients. The imaging features of primary hepatic angiosarcoma (PHA) (n = 11) included ill-defined margins (11/11, 100%), necrosis (5/11, 45%), calcification (3/11, 27%) and “slow in-slow out” centripetal enhancement (7/11, 64%). Patients with epithelioid hemangioendothelioma (EHE) (n = 15) presented with ill-defined margins (15/15, 100%), necrosis (6/15, 40%), calcification (2/15, 13%), “fast in-slow out” centripetal enhancement (10/15, 67%), halo sign (15/15, 100%), pseudocapsule sign (4/15, 27%), lollipop sign (2/15, 13%) and capsule retraction sign (2/15, 13%). Patients with malignant hemangiopericytoma (MHP) (n = 3) showed ill-defined margins (3/3, 100%), necrosis (3/3, 100%) and “fast in-slow out” progressive enhancement (3/3, 100%). Infantile hemangioendotheliomas (IHEs) (n = 13) were defined by ill-defined margins (7/13, 54%), necrosis (8/13, 62%), calcification (5/13, 38%) and “fast in-slow out” centripetal enhancement (13/13, 100%). Immunohistochemistry showed strong positive expression of CD31, CD34, ERG, FaVIII and FLI-1. Patients with IHE (96 months) and EHE (88 months) had the longest survival times, followed by those with MHP (23 months), while patients with PHA (15 months) had the shortest survival time.

Conclusion
On CT and MR images, most PHMVTs were ill-defined, heterogeneous, hypervascular masses with centripetal progressive enhancement and possibly calcification, especially in female patients. The prognosis of patients with PHMVT was associated with the pathological type of the tumor.
Theory to Practice: Performance Preparation Models in Contemporary High-Level Sport Guided by an Ecological Dynamics Framework
Authors: Woods Carl T. , McKeown Ian , O’Sullivan Mark , Robertson Sam , Davids Keith 
Published: August 2020

AbstractA fundamental challenge for practitioners in high-level sporting environments concerns how to support athletes in adapting behaviours to solve emergent problems during competitive performance. Guided by an ecological dynamics framework, the design and integration of competitive performance preparation models that place athlete-environment interactions at the heart of the learning process may address this challenge. This ecological conceptualisation of performance preparation signifies a shift in a coach’s role; evolving from a consistent solution provider to a learning environmentdesignerwho fosters local athlete-environment interactions. However, despite the past decades of research within the ecological dynamics framework developing an evidence-based, theoretical conceptualisation of skill acquisition, expertise and talent development, an ongoing challenge resides within its practical integration into sporting environments. This article provides two case examples in which high-level sports organisations have utilised an ecological dynamics framework for performance preparation in Australian football and Association Football. A unique perspective is offered on experiences of professional sport organisations attempting to challenge traditional ideologies for athlete performance preparation by progressing the theoretical application of ecological dynamics. These case examples intend to promote the sharing of methodological ideas to improve athlete development, affording opportunities for practitioners and applied scientists to accept, reject or adapt the approaches presented here to suit their specific ecosystems.
Software architectures for big data: a systematic literature review
Authors: Avci Cigdem , Tekinerdogan Bedir , Athanasiadis Ioannis N. 
Published: August 2020

AbstractBig Data systems are often composed of information extraction, preprocessing, processing, ingestion and integration, data analysis, interface and visualization components. Different big data systems will have different requirements and as such apply different architecture design configurations. Hence a proper architecture for the big data system is important to achieve the provided requirements. Yet, although many different concerns in big data systems are addressed the notion of architecture seems to be more implicit. In this paper we aim to discuss the software architectures for big data systems considering architectural concerns of the stakeholders aligned with the quality attributes. A systematic literature review method is followed implementing a multiple-phased study selection process screening the literature in significant journals and conference proceedings.
Coaching and mentoring: an overview for trainers in psychiatry
Authors: Huline-Dickens Sarah 
Published: August 2020

SUMMARYAlthough mentoring has been widely accepted as a support mechanism for newly appointed consultants, there are many other applications of coaching and mentoring that are less widely appreciated, such as in the development of leadership skills or in having coaching conversations with trainees to facilitate learning. This article summarises some of the basic principles and practices of coaching and mentoring, with a focus on useful knowledge for psychiatric trainers. It describes some of the qualities and skills needed in a coach or mentor; the use of questioning techniques and models; and how the coach or mentor needs an awareness of the importance of the contract in the coaching and mentoring relationship, of the role of coaching or mentoring supervision, and of the ability to evaluate coaching or mentoring. It also discusses some of the organisational context, challenges and opportunities of embedding coaching and mentoring more deeply into the work culture. It is argued that coaching and mentoring as supportive interventions have not been prioritised in the National Health Service in the same way that they have been in the private business sector, where performance and financial success are measurably increased by these techniques.
Economic Status Moderates the Association Between Early-Life Famine Exposure and Hyperuricemia in Adulthood
Authors: Wang Yuying , Weng Pan , Wan Heng , Zhang Wen , Chen Chi , Chen Yi , Cai Yan , Guo Minghao , Xia Fangzhen , Wang Ningjian , Lu Yingli 
Published: August 2020

Abstract

Context
The double burden of malnutrition (DBM), undernutrition in early life and an obesogenic environment later on, influences later risk of chronic disorders. The Great Famine in China from 1959 to1962 and remarkable economic development from the 1980s provided such a burden for a large number of people in their 60s.

Objective
We aimed to analyze the effect of economic status on the association between famine exposure in early life and hyperuricemia in adulthood.

Design and Setting
Participants numbering 12 666 were enrolled in China based on the Survey on Prevalence in East China for Metabolic Diseases and Risk Factors (SPECT-China) Study from 2014 to 2016.

Participants
Participants with fetal or childhood famine exposure (birth year 1949-1962) formed the exposure group.

Main Outcome Measure
Hyperuricemia was defined as uric acid (UA) &gt; 420 μmol/L for men and &gt; 360 μmol/L for women. The association of famine with hyperuricemia was assessed via regression analyses.

Results
Early-life famine exposure was negatively associated with UA levels (P = .045) but was not associated with hyperuricemia (P = .226) in the whole study population. Economic status could moderate the association of famine exposure with UA and hyperuricemia (P ≤ .001). In participants with high economic status, early-life famine exposure was positively associated with UA levels (unstandardized coefficients 7.61, 95% CI 3.63-11.59, P &lt; .001), and with hyperuricemia (odds ratio 1.47, 95% CI 1.19-1.81, P &lt; .001).

Conclusions
Economic status could moderate the association between exposure to famine in early life and hyperuricemia in adulthood, indicating that the DBM might affect hyperuricemia in an opposite direction of the effects of undernutrition in early life alone.
Subclinical Inflammation and Adipose Tissue Lymphocytes in Pregnant Females With Gestational Diabetes Mellitus
Authors: Cinkajzlová Anna , Anderlová Kateřina , Šimják Patrik , Lacinová Zdeňka , Kloučková Jana , Kratochvílová Helena , Krejčí Hana , Pařízek Antonín , Mráz Miloš , Kršek Michal , Haluzík Martin 
Published: August 2020

Abstract

Context
Gestational diabetes mellitus (GDM) is accompanied by subclinical inflammation; however, little is known about local inflammation in adipose tissue and placenta.

Objective
To analyze systemic and local subclinical inflammation and adipose tissue lymphocyte content and phenotype in pregnant women with and without GDM.

Design
Observational study.

Settings
Academic hospital.

Patients
Twenty-one pregnant women with GDM (GDM group), 16 pregnant women without GDM (non-GDM group) and 15 nonpregnant control women (N group).

Interventions
Serum samples taken at 28 to 32 (visit 1 [V1]) and 36 to 38 (V2) gestational weeks and 6 to 12 months after delivery (V3) in the GDM and non-GDM group and before elective gynecological surgery in the N group. Subcutaneous (SAT) and visceral adipose tissue (VAT) obtained during cesarean delivery or surgery.

Main Outcome Measures
Serum levels and adipose tissue expression of proinflammatory cytokines, adipose tissue lymphocyte content and phenotype (for a subset of GDM and non-GDM subjects).

Results
Accented proinflammatory state in GDM was documented by increased circulating tumor necrosis factor-α (TNF-α) levels. In both groups of pregnant females total lymphocytes were higher in VAT compared to SAT. In GDM subjects B cells and NKT cells were higher in SAT compared to VAT and T helper cells were increased relative to SAT of non-GDM group, while no intercompartmental adipose tissue differences were seen in non-GDM women.

Conclusions
Pregnant females had higher total lymphocyte count in VAT relative to SAT regardless of GDM. In addition to increased systemic subclinical inflammation, GDM was associated with significant differences in lymphocyte composition between subcutaneous and visceral adipose tissue depots.
Patient-centered Management of Type 2 Diabetes Mellitus Based on Specific Clinical Scenarios: Systematic Review, Meta-analysis and Trial Sequential Analysis
Authors: Pinto Lana C , Rados Dimitris V , Remonti Luciana R , Viana Luciana V , Pulz Georgia T , Carpena Mariana P , Borges Roberta P , Marobin Roberta , Beretta Mileni V , Pedrollo Elis F , Londero Thizá M , Machry Rafael , Janeczko Lais , Moehlecke Milene , Falcetta Mariana R , Bauer Andrea C , Silveiro Sandra P , Gerchman Fernando , Rodrigues Ticiana C , Kramer Caroline K , Bertoluci Marcello C , Leitão Cristiane B 
Published: August 2020

Abstract

Introduction
New antihyperglycemic medications have been proven to have cardiovascular (CV) and renal benefits in type 2 diabetes mellitus (T2DM); however, an evidence-based decision tree in specific clinical scenarios is lacking.

Materials and Methods
Systematic review and meta-analysis of randomized controlled trials (RCTs), with trial sequential analysis (TSA). Randomized controlled trial inclusion criteria were patients with T2DM from 1 of these subgroups: elderly, obese, previous atherosclerotic CV disease (ASCVD), previous coronary heart disease (CHD), previous heart failure (HF), or previous chronic kidney disease (CKD). Randomized controlled trials describing those subgroups with at least 48 weeks of follow-up were included. Outcomes: 3-point major adverse cardiovascular events (MACE), CV death, hospitalization due to HF, and renal outcomes. We performed direct meta-analysis with the number of events in the intervention and control groups in each subset, and the relative risk of the events was calculated.

Results
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists (GLP-1 RA) were the only antihyperglycemic agents related to a reduction in CV events in different populations. For obese and elderly populations, GLP-1 RA were associated with benefits in 3-point MACE; for patients with ASCVD, both SGLT2i and GLP-1 RA had benefits in 3-point MACE, while for patients with CHD, only SGLT2i were beneficial.

Conclusions
SGLT2i and GLP-1 RA reduced CV events in selected populations: SGLT2i led to a reduction in events in patients with previous CHD, ASCVD, and HF. GLP-1 RA led to a reduction in CV events in patients with ASCVD, elderly patients, and patients with obesity. Trial sequential analysis shows that these findings are conclusive. This review opens a pathway towards evidence-based, personalized treatment of T2DM.

Registration
PROSPERO CRD42019132807
MicroRNA-15b Targets VEGF and Inhibits Angiogenesis in Proliferative Diabetic Retinopathy
Authors: Yang Ying , Liu Yan , Li Yiping , Chen Zhongli , Xiong Yixin , Zhou Taicheng , Tao Wenyu , Xu Fan , Yang Hanling , Ylä-Herttuala Seppo , Chaurasia Shyam S , Adam Whaley-Connell , Yang Ke 
Published: August 2020

AbstractBackgroundVascular endothelial growth factor (VEGF)-induced angiogenesis is a critical compensatory response to microvascular rarefaction in the diabetic retina that contributes to proliferative diabetic retinopathy (PDR). In this study, we sought to determine the role of specific micro ribonucleic acids (RNAs) (miRs) associated with VEGF in patients with PDR pathology.MethodsRNA sequencing was employed to detect differentially circulating miR associated with VEGF in patients with diabetes mellitus (DM), nonproliferative diabetic retinopathy (NPDR) and PDR. Quantitative real-time polymerase chain reaction was performed to measure the concentration of miR-15b in the serum of patients with DM (n = 115), NPDR (n = 47), or PDR (n = 76). The effects of miR-15b on DR and regulation of VEGF and endothelial cell function were also characterized.ResultsWe demonstrated that circulating miR-15b was directly associated with VEGF compared with other miRs in patients with PDR. We found a significant inverse relationship between low levels of miR-15b and high levels of VEGF in patients with PDR when compared with the DM or NPDR groups. We found that miR-15b regulates the expression of VEGF by targeting the 3'-untranslated regions to inhibit its transcription. Similarly, overexpression of miR-15b suppressed vascular abnormalities in vivo in diabetic GK rats, inhibiting endothelial tube formation and VEGF expression.ConclusionCirculating miR-15b is associated with PDR and may be targeted to regulate VEGF expression and angiogenesis.
Broadband and high extinction ratio hybrid plasmonic waveguide-based TE-pass polarizer using multimode interference
Authors: Wu Shengbao , Xiao Jinbiao , Feng Ting , Yao X. Steve 
Published: August 2020

A TE-pass polarizer based on multiple hybrid plasmonic waveguides (HPWs) is proposed, where the polarizer section consists of four symmetrically placed HPWs and a single-mode silicon waveguide in between. Owing to the strong polarization-dependent absorption loss of the multiple HPWs, the unwanted TM polarized light is strongly attenuated while TE polarized light passes through with little loss. In addition, the multimode interference (MMI) effect is further utilized to strip out TM mode, resulting in more compact device size. To improve the extinction ratio (ER) and operating bandwidth (OBW) of the device, a three-stage cascaded scheme is utilized. Results show that a compact device with a length of

∼

26

µ

m

, an ultra-high ER of over 60 dB, and a low insertion loss (IL) of 0.15 dB is obtained at the wavelength of 1.55 µm, with a broad OBW of over 240 nm for an

E
R

>

40

d
B

. Compared with the recently reported silicon TE-pass polarizers, the present device shows better performance in terms of ER and bandwidth with a comparable device footprint.
Dispersive optomechanics of supercavity modes in high-index disks
Authors: Mercadé Laura , Barreda Ángela , Martínez Alejandro 
Published: August 2020

In this work, we study the dispersive coupling between optical quasi-bound states in the continuum at telecom wavelengths and GHz-mechanical modes in high-index wavelength-sized disks. We show that such cavities can display values of the optomechanical coupling rate on par with optomechanical crystal cavities (

g
0

/

2
π
≃
800

k
H
z

). Interestingly, optomechanical coupling of optical resonances with mechanical modes at frequencies well above 10 GHz seems attainable. We also show that mechanical leakage in the substrate can be extremely reduced by placing the disk over a thin silica pedestal. Our results suggest a new route for ultra-compact optomechanical cavities that can potentially be arranged in massive arrays forming optomechanical metasurfaces for application in signal processing or sensing.
Primer on silicon neuromorphic photonic processors: architecture and compiler
Authors: Ferreira de Lima Thomas , Tait Alexander N. , Mehrabian Armin , Nahmias Mitchell A. , Huang Chaoran , Peng Hsuan-Tung , Marquez Bicky A. , Miscuglio Mario , El-Ghazawi Tarek , Sorger Volker J. , Shastri Bhavin J. , Prucnal Paul R. 
Published: August 2020

AbstractMicroelectronic computers have encountered challenges in meeting all of today’s demands for information processing. Meeting these demands will require the development of unconventional computers employing alternative processing models and new device physics. Neural network models have come to dominate modern machine learning algorithms, and specialized electronic hardware has been developed to implement them more efficiently. A silicon photonic integration industry promises to bring manufacturing ecosystems normally reserved for microelectronics to photonics. Photonic devices have already found simple analog signal processing niches where electronics cannot provide sufficient bandwidth and reconfigurability. In order to solve more complex information processing problems, they will have to adopt a processing model that generalizes and scales.Neuromorphic photonicsaims to map physical models of optoelectronic systems to abstract models of neural networks. It represents a new opportunity for machine information processing on sub-nanosecond timescales, with application to mathematical programming, intelligent radio frequency signal processing, and real-time control. The strategy of neuromorphic engineering is to externalize the risk of developing computational theory alongside hardware. The strategy of remaining compatible with silicon photonics externalizes the risk of platform development. In this perspective article, we provide a rationale for a neuromorphic photonics processor, envisioning its architecture and a compiler. We also discuss how it can be interfaced with a general purpose computer, i.e. a CPU, as a coprocessor to target specific applications. This paper is intended for a wide audience and provides a roadmap for expanding research in the direction of transforming neuromorphic photonics into a viable and useful candidate for accelerating neuromorphic computing.
High Temperature Tribology of A413/B4C Nanocomposites under Dry Sliding Contact
Authors: Shinde Deepak M. , Poria Suswagata , Sahoo Prasanta 
Published: August 2020

Abstract
In this work, boron carbide (B4C) particulate (0.5, 1.0, 1.5, and 2.0 weight %) reinforced A413 alloy nanocomposites were fabricated by ultrasonic stir casting method. The prepared aluminum matrix nanocomposites were characterized using optical microscopy and field emission scanning electron microscopy to observe particle dispersion and quantify microstructural features. A high temperature pin-on-disk tribo-tester was employed to investigate the dry sliding tribological behavior of fabricated nanocomposites and unreinforced alloy at a constant speed (0.66 m/s) and different loads (20, 60 N) over the temperature range of 50°C–200°C. Specimens were slid against an AISI SAE 52100 counterface for the fixed duration of 10 minutes. Worn surfaces were examined under the scanning electron microscopy, and energy dispersive spectroscopy analysis was carried out to understand the wear mechanisms. It was revealed that the wear resistance of the alloy improved because of increasing B4C content. The wear rate of all specimens was found to increase with increased load and operating temperatures. A shift in the mild oxidative to severe metallic wear of an unreinforced alloy was seen increased by about 50°C–80°C because of particulate reinforcement. The mild abrasive wear mechanism of the base alloy at low temperature was changed to adhesion with heavy plastic deformation at elevated temperature. Increased thermal stability offered by boron carbide particles and oxides and a mechanically mixed transfer layer were key factors enhancing the wear resistance of the nanocomposites. Under the tested experimental conditions A413/B4C nanocomposite was found suitable and better than the base alloy for use in wear resistance applications.
Determinant of Willingness to Pay Health Insurance Contribution to Informal Workers
Authors: Witati Witati , Putri Phany Ineke 
Published: August 2020

The purpose of this study was to analyze the willingness to pay contributions of informal workers and the factors that affect the willingness to pay contribution of Badan Penyelenggara Jaminan Sosial (BPJS) Kesehatan for informal workers in Brebes Regency. Descriptive research with quantitative approach method is used in this study. Data analysis method uses logistic regression method. The results showed that 71 respondents were willing to pay contribution of Badan Penyelenggara Jaminan Sosial (BPJS) Kesehatan for the sustainability of the program and improve the quality of service facilities and 29 respondents said they were not willing to pay. Factors that have a significantly affect on willingness to pay for informal workers are income variable, number of family members, and history of catastrophic disease. Whereas the factors that have no significant on willingness to pay are the last education variable and knowledge. The policy implication for local governments is to increase productivity in the informal sector which aims to increase income of informal workers and re-record Pekerja Bukan Penerima Upah (PBPU) participants who are economically incapable to be transferred to Penerima Bantuan Iuran (PBI) participants. Increase knowledge related to the importance of paying contributions to Pekerja Bukan Penerima Upah (PBPU) participants by Badan Penyelenggara Jaminan Sosial ( BPJS) Kesehatan.