bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rehabilitation Therapy for Vocal Fold Paralysis Caused by Lung Cancer: A Case Report
Authors: Lu Qing Yi , Zhang Bin , Jin Ke Xin , Jiang Wan Ling , Li Xiang , Gao Chang Yue 
Published: September 2020

Abstract

Objective
Unilateral vocal fold paralysis (UVFP) can be caused by iatrogenic injury or tumor-induced damage to the recurrent laryngeal nerve. Studies of comprehensive rehabilitation therapies for patients suffering from severe UVFP are limited. The purpose of this case report is to describe an improvement in complete aphonia after comprehensive rehabilitation therapies in a patient with severe UVFP due to a lung tumor.

Methods
An 81-year-old woman with a history of bronchial adenoma had complete aphonia due to compression of the left recurrent laryngeal nerve by the tumor. Dynamic fibrolaryngoscope revealed paralysis of the left vocal fold. The patient was treated with interferential current therapy, vocal training, and kinesiology taping. Indicators of voice recovery were scored according to the grade, roughness, breathiness, asthenia, strain scale, and the voice handicap index.

Results
After 10 days of comprehensive rehabilitation treatment, the patient recovered from complete aphonia to normal communication. The hoarseness and breathiness of patient were significantly improved. In addition, the grade, roughness, breathiness, asthenia, strain, and the voice handicap index scores changed from severe to mild or absent.

Conclusion
This case provided a novel comprehensive treatment for a patient with UVFP, which was safe, cost-effective, and easy to implement in clinic.
Patient-reported outcomes for ambulatory surgery
Authors: Warnakulasuriya Samantha R. , Patel Reshma C. , Singleton Georgina F. , Moonesinghe S. Ramani 
Published: September 2020

Purpose of review
To discuss the importance of validated tools that measure patient-reported outcomes and their use in ambulatory surgery.

Recent findings
Sustained increases in ambulatory surgical care reflect advances in surgical techniques and perioperative anaesthetic care. Use of patient-reported outcomes allows identification of minor adverse events that are more common in this population compared with traditional endpoints such as mortality. Variability in reported outcomes restricts research potential and limits the ability to benchmark providers. The standardized endpoints in perioperative medicine initiative's recommendations on patient-reported outcomes and patient comfort measures are relevant to evaluating ambulatory care. Combining validated generic and disease-specific patient-reported outcome measures (PROMs) examines the widest spectrum of outcomes. Technological advances can be used to facilitate outcome measurement in ambulatory surgery with digital integration optimizing accurate real-time data collection. Telephone or web-based applications for reviewing ambulatory patients were found to be acceptable in multiple international settings and should be harnessed to allow remote follow-up.

Summary
Use of validated tools to measure patient-reported outcomes allows internal and external quality comparison. Tools can be combined to measure objective outcomes and patient satisfaction. These are both key factors in driving forward improvements in perioperative ambulatory surgical care.
Blood-Pool SPECT/CT in Chronic Ankle Tendinopathy
Authors: Cuvilliers Cécile , Icard Nicolas , Meneret Pierre , Palard-Novello Xavier , Girard Antoine 
Published: September 2020

Abstract
We report 2 cases where blood-pool SPECT/CT had a high added value compared with standard 3-phase bone scintigraphy with only delayed SPECT/CT for the etiological diagnosis of painful ankles. Two men, aged 48 and 62 years, were referred for suspicions of medial and lateral malleoli stress fractures, respectively. Although standard planar blood-pool imaging and delayed SPECT/CT were inconclusive, blood-pool SPECT/CT showed markedly increased uptake along posterior tibial tendon and peroneal tendon, respectively, leading to diagnose tendonitises. These cases illustrate that blood-pool SPECT/CT can extend the diagnostic yield of bone scintigraphy to extraosseous origin, particularly in chronic lower extremities pain.
Superior Vena Cava Syndrome Induced Collateral Circulation on 99mTc–Macroaggregated Albumin Lung Perfusion Scintigraphy
Authors: Kersting David , Guberina Nika , Umutlu Lale , Stuschke Martin , Hautzel Hubertus 
Published: September 2020

Abstract
Perfusion lung scintigraphy using SPECT/CT is one mainstay in diagnosing pulmonary embolism. Although typically almost all tracer will be accumulated in the lung capillaries, occasionally abnormal uptake can be detected. As superior vena cava syndrome leads to aberrant blood flow, tracer injected to an arm vein might partly circumvent the pulmonary capillary bed and accumulate in well-perfused anatomical structures. In this case, next to the commonly described liver enhancement, more prominent pseudo-uptake of various thoracic vertebrae was observable. However, a time-related FDG PET/CT demonstrated only the hepatic pseudo-uptake. Taken together, careful assessment of superior vena cava syndrome patient studies is highly recommended.
A Case of Localized Malignant Peritoneal Mesothelioma Evaluated by 18F-FDG PET/CT
Authors: Xu Tingting , Hu Jiajia , Zhang Xinyi , Cao Jianpeng , Chen Yue 
Published: September 2020

Abstract
Localized malignant mesothelioma is rare. The prognosis is generally more favorable for this condition than for diffuse malignant mesothelioma. An elderly woman recently complained of abdominal pain, fever, and weight loss. She had no history of asbestos exposure. Her serum CEA level was elevated. Plain CT revealed a mass under the left diaphragm, with liquefaction and necrosis. A contrast-enhanced scan showed circular enhancement of the mass. A subsequent biopsy of the mass revealed a poorly differentiated carcinoma. PET/CT showed a significant FDG-avid subphrenic mass without any indications of metastasis. Postoperative pathological and immunohistochemical examination confirmed a case of malignant mesothelioma.
Ectopic Parathyroid Adenoma of the Piriform Sinus on Parathyroid 4D-CT and 99mTc-MIBI SPECT/CT
Authors: Hsieh Meng-Chieh P. , Nemer John S. , Beylergil Volkan , Yeh Randy 
Published: September 2020

Abstract
Ectopic parathyroid adenomas are a common cause of postsurgical persistent primary hyperparathyroidism. Our case highlights a patient with a negative bilateral 4-gland exploration with follow-up parathyroid 4-dimensional CT and 99mTc-MIBI SPECT/CT, yielding focal uptake in the right piriform sinus. Subsequent direct laryngoscopy revealed a mass in the piriform sinus, which was resected with surgical pathology yielding parathyroid adenoma.
Before and After Treatment Characterization of Cerebrospinal Disease in Bing-Neel Syndrome Using 18F FDG PET/MRI
Authors: Riaz Saima , Priftakis Dimitrios , Arulogun Suzanne , Wan Simon , Bomanji Jamshed 
Published: September 2020

Abstract
Bing-Neel syndrome is a rare neurological complication of Waldenström macroglobulinemia. We present the case of a 71-year-old man who underwent prechemotherapy and postchemotherapy FDG PET/MRI scan for the evaluation of cerebrospinal disease. In light of limited literature and lack of consensus guidelines on the role of metabolic imaging, we aim to highlight the utility of FDG PET/MRI in the diagnosis and response assessment in Bing-Neel syndrome.
Incidental Detection of a Small Cell Lung Cancer by 18F-Choline PET/CT Performed for Recurrent Hyperparathyroidism After Parathyroidectomy
Authors: Jacquet-Francillon Nicolas , Granjon Denise , Casteillo François , Prévot Nathalie , Habouzit Vincent 
Published: September 2020

Abstract
We report the case of a 64-year-old woman with musculoskeletal pain and elevated serum parathyroid hormone who had undergone parathyroidectomy for primary hyperparathyroidism 4 years earlier. An 18F-choline PET/CT scan was performed and incidentally showed an intense uptake in a right upper lobe pulmonary nodule and in the right hilar, mediastinal, and cervical lymph nodes. Histopathological analysis confirmed the diagnosis of a small cell lung cancer. Clinical symptoms and recurrent hyperparathyroidism were therefore consistent with a paraneoplastic syndrome. A complete metabolic response was achieved on 18F-FDG PET/CT scan after chemotherapy.
Quality and Safety in Healthcare, Part LXXIX
Authors: Harolds Jay A. , Miller Laura B. 
Published: September 2020

Abstract
Most executives new to a health care organization should have introductory and development programs during their first year, which should include networking opportunities, special projects to improve skills, independent or assigned course work, multiple types of assessments, and periodic discussions regarding expectations about their work and their progress in achieving them. It is preferable for the organization and the new executive to have information from outside sources about how a person in that position can achieve success and the reasons for turnover in the position. This is discussed in this article, using the chief nursing officer as the example.
Even Small Pleural Effusion Could Be Potential Pitfall on Posttherapeutic 131I Scintigraphy
Authors: Peng Dong , Shao Fuqiang 
Published: September 2020

Abstract
Pleural and pericardiac effusion could have radioiodine accumulation and be potential pitfall on posttherapeutic 131I whole-body scintigraphy. However, the volume of the effusion was relatively massive in the previous publications. We report a case of pleural effusion with a very small volume also had radioiodine uptake in a 37-year-old man.
68Ga-PSMA–Avid Small Cell Lung Cancer on PET/CT
Authors: Sharma Punit 
Published: September 2020

Abstract

68Ga–prostate-specific membrane antigen (68Ga-PSMA) PET/CT has shown excellent results in imaging of prostate cancer. Some nonprostatic malignancies can also demonstrate 68Ga-PSMA uptake, including primary lung adenocarcinoma. However, no such data are present for small cell lung cancer. We present the case of a 59-year-old man, where a second primary metastatic small cell lung cancer was discovered on 68Ga-PSMA PET/CT done for suspected recurrence of prostate cancer.
Malignant Peripheral Nerve Sheath Tumor Arising From Transplanted Kidney Assessed by 18F-FDG PET/CT
Authors: Feng Hongyan , Tu Ning , Bu Lihong 
Published: September 2020

Abstract
Malignant peripheral nerve sheath tumor (MPNST) originates from Schwann cells or pluripotent perineural cells, which is an extremely rare tumor that occurs in the kidney. We report a case of MPNST in transplanted kidney that was diagnosed in a 32-year-old man with a history of kidney transplantation. Contrast-enhanced MRI and 18F-FDG PET/CT features of MPNST are described, which can accurately discriminate MPNST from infection and benign tumors. These features could potentially provide valuable information to distinguish it from other renal malignancies. 18F-FDG PET/CT may be a useful tool for the primary diagnosis and the initial staging of MPNST.
Iatrogenic Lung Microembolism Resulted in Extraosseous Uptake of 99mTc-MDP
Authors: Lei Lei , Deng Yan , Ding Haoyuan , Zhang Wei 
Published: September 2020

AbstractA 61-year-old woman diagnosed with left breast cancer underwent a bone scan for the evaluation of possible bone metastases. Multiple foci of elevated activity were noticed in the spine and pelvis. In addition, a focus of intense activity was observed in the right lung on the SPECT/CT images without corresponding anatomic abnormality.
Solitary Acute Inflammatory Demyelinating Lesion of the Cervical Spinal Cord Mimicking Malignancy on FDG PET/CT
Authors: Liu Qianyun , Liu Mingyuan , Bai Yushu , Dong Aisheng 
Published: September 2020

Abstract
A 43-year-old woman presented with numbness of the left hand and leg for 4 weeks. MRI of the spinal cord revealed an intramedullary lesion with central nodular enhancement at the C3 level. Primary tumor or metastasis of the cervical spinal cord was suspected. FDG PET/CT showed focal hypermetabolism of the spinal cord corresponding to the gadolinium-enhanced nodule. The patient underwent resection of the cervical spinal cord lesion. Histopathological findings of the resected specimens were consistent with acute inflammatory demyelinating lesion.
18F-Fluciclovine Uptake in Thymoma Demonstrated on PET/MRI
Authors: Tsikitas Lucas , Karls Shawn , Kranz Anca-Oana , Friedman Kent P. , Mahajan Sonia 
Published: September 2020

Abstract
A 68-year-old man with a history of prostate cancer post–primary treatment presented with rising prostate-specific antigen levels and was referred for 18F-fluciclovine PET/MRI to localize recurrent disease. PET/MRI revealed a solitary focus of uptake in a soft tissue nodule in the anterior mediastinum, which was resected and found to be a type B2 thymoma. 18F-fluciclovine uptake is mediated by amino acid transporters, primarily alanine-serine-cysteine transporter 2 and l-type amino acid transporter 1, previously demonstrated to be expressed on thymic carcinomas. This case highlights the possibility of overexpression of amino acid transporters in thymomas as well, rarely described before.
Orbital Emphysema Secondary to Frontal Osteoma
Authors: Devaraja K , Pujary Kailesh , Pillai Suresh 
Published: September 2020

Abstract
Repeated bouts of nose blowing can at times lead to orbital emphysema due to stress fracture in the medial or the inferior wall of the orbit. Very rarely, this can result from paranasal sinus osteoma rendering the orbital wall weak. We report only the fifth case of literature to have such an association. Also, we managed our case non-surgically, as against the previous reports treated surgically. In discussion, we highlight the nuances related to principles of management, including the role of computed tomography, and surgical intervention.
Three-Dimensionally-Printed Bioactive Ceramic Scaffolds: Construct Effects on Bone Regeneration
Authors: Fama Christopher , Kaye Gabriel J. , Flores Roberto , Lopez Christopher D. , Bekisz Jonathan M. , Torroni Andrea , Tovar Nick , Coelho Paulo G. , Witek Lukasz 
Published: September 2020

Background/Purpose:The utilization of three-dimensionally (3D)-printed bioceramic scaffolds composed of beta-tricalcium phosphate in conjunction with dipyridamole have shown to be effective in the osteogenesis of critical bone defects in both skeletally immature and mature animals. Furthermore, previous studies have proven the dura and pericranium's osteogenic capacity in the presence of 3D-printed scaffolds; however, the effect galea aponeurotica on osteogenesis in the presence of 3D scaffolds remains unclear.Method/Description:Critical-sized (11 mm) bilateral calvarial defects were created in 35-day old rabbits (n = 7). Two different 3D scaffolds were created, with one side of the calvaria being treated with a solid nonporous cap and the other with a fully porous cap. The solid cap feature was designed with the intention of preventing communication of the galea and the ossification site, while the porous cap permitted such communication. The rabbits were euthanized 8 weeks postoperatively. Calvaria were analyzed using microcomputed tomography, 3D reconstruction, and nondecalcified histologic sectioning in order assess differences in bone growth between the two types of scaffolding.Results:Scaffolds with the solid (nonporous) cap yielded greater percent bone volume (P = 0.012) as well as a greater percent potential bone (P = 0.001) compared with the scaffolds with a porous cap. The scaffolds with porous caps also exhibited a greater percent volume of soft tissue (P < 0.001) presence. There were no statistically significant differences detected in scaffold volume.Conclusion:A physical barrier preventing the interaction of the galea aponeurotica with the scaffold leads to significantly increased calvarial bone regeneration in comparison with the scaffolds allowing for this interaction. The galea's interaction also leads to more soft tissue growth hindering the in growth of bone in the porous-cap scaffolds.
New insights underlying the early events of dopaminergic dysfunction in Parkinson’s Disease
Authors: Dela Cruz Hannah L. , Dela Cruz Esther L. , Zurhellen Cody J. , York Herbert T. , Baun Jim A. , Dela Cruz Joshua L. , Dela Cruz Jay S. 
Published: September 2020

AbstractAlpha melanocyte-stimulating hormone (α-MSH) is an autocrine factor released by activated microglia during neuroinflammation and is elevated in the cerebrospinal fluid of Parkinson’s disease (PD) patients.α-MSH impaired cellular autophagy and induced the accumulation of alpha-synuclein in a melanized human dopaminergic cell model. Increasedα-MSH in the brain of mice resulted in the gradual worsening of abnormal gait. Dopamine replacement with L-dopa/Benserazide or treatment with a dopamine receptor agonist, Pramipexole, temporarily restored normal gait, suggesting dopamine deficiency as the cause of motor deficits in these mice. Notably, end-stage disease pathology such as neuronal cell loss, reduction in tyrosine hydroxylase (TH)+ fiber density in the striatum and pSer129+ alpha-synuclein inclusions were absent. Rather, autophagic dysfunction was observed in the dopaminergic neuronal (DN) cell population within the substantia nigra pars compacta and ventral tegmental area. Moreover, increased expression of TH was observed in the striatum, suggesting a compensatory response to diminished dopamine levels. Our findings provide new insights into the early events that underlie neurodegeneration in PD and suggest that exposure of DNs to elevated levels of microglialα-MSH leads to impairment of autophagy resulting in abnormal accumulation of proteins, dopaminergic dysfunction and motor deficits.Graphical abstractSignificance statementWe now show that a naturally occurring compound increased in the brain of Parkinson’s disease (PD) patients, calledα-MSH, can trigger abnormal accumulation of alpha-synuclein in a dopaminergic cell model. Increasingα-MSH in the brain of mice resulted in motor symptoms and abnormal gait. Increasing dopamine activity in these mice using Levodopa or Pramipexole restored normal gait, suggesting that the mice were deficient in dopamine, as seen in PD. We now describe a cell and an animal model that can reproduce the early stages of dopaminergic dysfunction in PD. These new pre-clinical research tools will be useful in developing effective drugs that will stop the progression of the disease in patients who suffer from PD.AbbreviationsPD, Parkinson’s disease; DN, dopaminergic neuron;α-MSH, alpha-melanocyte stimulating hormone; TH, tyrosine hydroxylase; SNpc, substantia nigra pars compacta; VTA, ventral tegmental area; CNS, central nervous system; CSF, cerebrospinal fluid; INS, intranasal; ASIP, agouti-signaling protein; MC1R, melanocortin receptor 1; ROS, reactive-oxygen species; MSA, multiple system atrophy
ASSESSMENT OF PROFESSIONALISM IN NURSING AND FACTORS ASSOCIATED AMONG NURSES WORKING IN ARSI ZONE PUBLIC HOSPITALS, OROMIA, ETHIOPIA, 2018
Authors: Tola Mulugeta Degefa , Tafesa Fikru , Siraneh Yibeltal 
Published: September 2020

AbstractBackgroundProfessionals are defined in the context of a particular body of knowledge which is obtained through formal education, expanded level of skills, type of certification proving their entry into the profession; a set of behavioral norms called professionalism and attitudes representing high levels of commitment to and identification with a specific profession. Several factor affecting the development of the nursing profession. Recognizing and determining such factors can be the first step to move towards the professionalization of nursing. The objective of this study was to assess professionalism in nursing and factors associated among nurses working in Arsi zone, Public Hospitals, Oromia, Ethiopia 2018.MethodsThis study used an Institutional based cross sectional study design. Self-administered structured questionnaire adapted from RNAO (Registered Nurses’ association of Ontario) guideline, was used to measure the level of professionalism. The sample was 420 nurses from the six Public Hospitals of Arsi Zone, Oromia, Ethiopia. Data was analyzed using SPSS 20.0. Both bivariate and multivariate analysis were carried out to identify associations. Odds ratio was calculated for related factors with 95% confidence interval (CI). A p-value < 0.05 was considered to be statistically significant.ResultOut of 420 Nurses working in six public Hospitals, 380 responded to the questionnaire, making the response rate of 90.5%. In current study level of professionalism was high among nurses (n=380) with highest percentages on accountability, advocacy, and ethics. Gender (AOR=2.489, 95% CI=1.540-4.023), nursing is indispensable (AOR=1.760, 95% CI=1.104-2.806), job satisfaction (AOR= 1.844, 95% CI = 1.143-2.975) and having up to dated training (AOR= 1.809, 95%CI=1.071-3.055 were significantly associated with overall professionalism level.ConclusionNurses working in public hospitals of Arsi zone have relatively had better professionalism level. Gender, nursing is indispensable, job satisfaction, presence of up-to-dated trainings were found significantly associated with professionalism in nursing. Human resource personnel and CEO’s of respective hospitals should develop various training programs for nurses and provide encouraging environments for obtaining better qualities in attributes of professionalism.
Impact of stopping therapy during the SARS-CoV-2 pandemic in persons with lymphoma
Authors: Yang Shenmiao , Dong Dong , Gu Hongfei , Gale Robert Peter , Ma Jun , Huang Xiaojun 
Published: September 2020

IntroductionThe severe acute respiratory syndrome-2 (SARS-CoV-2) pandemic disrupted medical care for persons with cancer including those with lymphoma. Many professional societies recommend postponing, decreasing or stopping anti-cancer therapy in selected persons during the pandemic. However, although seemingly sensible these recommendations are not evidence-based and their impact on anxiety and health-relatedquality-of-life(HRQoL) is unknown.MethodsSurveyed 2532 subjects including 1060 persons with lymphoma, 948 caregivers and 524 normal, uninvolved persons using a purposed-designed questionnaire on a patient organization website. Respondents also completed the Zung Self-Rating Anxiety and patient respondents, the EORTC QLQ-C30 instruments to quantify anxiety and HRQoL. We also evaluated caregiver support and an online education programme of the Chinese Society of Clinical Oncology (CSCO). Data of HRQoL from a 2019 pre-pandemic online survey of 1106 persons with lymphoma was a control.Results33% (95% Confidence Interval [CI] 30, 36%) of lymphoma patients and 31% (28, 34%) of caregivers but only 21% (17, 24%) of normal individuals had any level of anxiety (both pair-wiseP< 0.001). Amongst lymphoma respondents physical exercise and better caregiver support were associated with less anxiety whereas female sex, receiving therapy and reduced therapy intensity were associated with more anxiety. Paradoxically, lymphoma respondents during the pandemic had better HRQoL than pre-pandemic controls. Reduced therapy intensity was associated with worse HRQoL whereas respondents who scored caregiver support and the online patient education programme high had better HRQoL.ConclusionsDuring the SARS-CoV-2 pandemic lymphoma patients and their caregivers had significantly higher incidence of anxiety compared with normals. Lymphoma respondents reported better HRQoL compared with pre-pandemic controls. Reduced therapy-intensity in patients with cancer may have unanticipated adverse effects on anxiety and HRQoL. Regular and intense support by caregivers and online education programmes alleviate anxiety and improve HRQoL.