bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymorphism rs6478109 in the TNFSF15 gene contributes to the susceptibility to Crohn’s disease but not ulcerative colitis: a meta-analysis
Authors: Zhou Yuan , Zhu Yi , Jiang HongGang , Chen ZhiHeng , Lu BoHao , Li Jin , Shen Xuning 
Published: October 2020

Objective Polymorphisms in the tumor necrosis factor superfamily 15 ( TNFSF15) gene contribute to susceptibility to inflammatory bowel disease (IBD). However, associations between TNFSF15 rs6478109, rs7869487, and rs7865494 polymorphisms and IBD remain unclear. Methods Eligible articles were retrieved from the PubMed, EMBASE, Web of Science, and CNKI databases through 20 March 2020. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the relationships of TNFSF15 polymorphisms with IBD susceptibility. Results Under the recessive model, TNFSF15 rs6478109 was associated with IBD risk (OR = 0.56; 95% CI: 0.35, 0.92). Stratification analyses based on the type of disease—Crohn’s disease (CD) or ulcerative colitis (UC)—revealed a significant association under the allelic and recessive models between TNFSF15 rs6478109 and CD (allelic model: OR = 0.84, 95% CI: 0.71, 0.99; recessive model: OR = 0.44, 95% CI: 0.22, 0.87) but not UC. Stratification by ethnicity indicated a significantly decreased risk of IBD in Asian populations with TNFSF15 rs6478109 under the recessive model (OR = 0.56, 95% CI: 0.35, 0.92). Conclusions Our meta-analysis suggested that under the allelic and recessive models, the TNFSF15 rs6478109 polymorphism was likely protective for CD but not UC in the Asian population.
A Comparative Study of the In-Built Torque and Slot Size of MBT Prescription Bracket of Different Manufacturing Companies: A Stereo-Microscopic Study
Authors: Mathew Ashish , Kumar HC Kiran , Shetty Sadashiva 
Published: October 2020

Torque is produced by a twist in an “archwire” that creates a couple when interacted with a “bracket slot.” Depending on the magnitude of the twist, the size of the wire, the built-in torque and the size of the slot, the archwire expresses torsional forces to the teeth. When brackets are manufactured, some variations may inadvertently occur in the dimensions of the bracket slot. Hence this study was done to determine the accuracy of different manufacturer’s dimensions of bracket slots and the built-in torque. Method: Seven upper right central incisor brackets of Mclaughlin Bennet and Trevisi (MBT) prescription with 0.022-inch slot from 5 different manufacturers were taken to assess the accuracy of bracket slot dimensions and built-in torque. A stereomicroscope was used to accurately determine slot dimensions and built-in torque. Results: The results showed that all the bracket slots measured in this study were oversized when compared to the standard value. Dentaurum showed significant difference from the ideal slot size and brackets from JJ Orthodontics and Desires showed highly significance difference from ideal slot size. The mean values for built in torque were less in all the brackets. The brackets from JJ Orthodontics and Desires showed highly significant difference from the ideal built in torque values. Interpretation and Conclusion: The above findings of the study suggest that one should be cautious when choosing a commercially available brand in day to day practice as some of the materials may not fulfill the desired standards.
The feasibility of a combined model of online interventions for adults with cancer-related cognitive impairment
Authors: Maeir Talia , Nahum Mor , Makranz Chen , Hoba Afik , Peretz Tamar , Nagary Shai Netanel , Silberman Nechama , Gilboa Yafit 
Published: October 2020

Introduction The purpose of this study was to test the feasibility of a telehealth intervention combining computerised cognitive training and occupation-based treatment among adult cancer survivors experiencing cancer-related cognitive impairment. Method This was a single-arm study including six cancer survivors with cancer-related cognitive impairment. Participants completed the computerised retraining and functional treatment intervention consisting of 10 hours of computerised cognitive training (BrainHQ) and approximately 10 1:1 remote sessions with an occupational therapist using an occupation-based approach. Feasibility was measured in terms of recruitment, adherence, acceptability and potential effectiveness. Assessments were administered at baseline, post-intervention and at 3-month follow-up and included measures of occupational performance, objective cognitive functions, quality of life and mood questionnaires. Results From the nine participants enrolled in the study, six completed 8–13 weeks of computerised retraining and functional treatment intervention and reported high satisfaction levels. Positive and significant improvements were found in occupational performance, useful field of view and social quality of life (all P < 0.05). The positive gains were maintained at the 3-month follow-up. Conclusion A combined model of computerised cognitive training and occupation-based treatment delivered remotely to adults with cancer-related cognitive impairment was found feasible and may improve occupational performance, cognitive functions and quality of life.
Longitudinal study of prosthesis use in veterans with upper limb amputation
Authors: Resnik Linda , Borgia Matthew , Biester Sarah , Clark Melissa A 
Published: October 2020

Background:
Little is known about the patterns of prosthesis use and satisfaction of those who cease use or begin to use upper limb prostheses.

Objectives:
Among a longitudinal sample of Veterans with upper limb amputation, (1) describe changes in prosthesis use over 1 year, (2) examine rates of receipt of new prostheses, and (3) compare prosthesis satisfaction in respondents who received a new prosthesis to those who did not.

Study Design:
Longitudinal survey.

Methods:
808 Veterans who had participated in a baseline interview 1 year earlier were invited to participate in structured telephone interviews.

Results:
A total of 562 persons with unilateral and 23 with bilateral amputation participated in the interviews (Response rate = 72.4% and 85.2%, respectively). Prosthesis use, frequency and intensity of use, and types of prostheses used were stable over 1 year. About 24% reported using a different primary terminal device type at follow-up than baseline. Prosthesis use was less frequent/intense at baseline among those who discontinued use compared with those who did not (P < 0.05), and less frequent/intense for those who started compared with those who continued using a prosthesis (P < 0.0001). Rates of prosthetic training were higher among those who received a different prosthesis type compared with those using the same type (P = 0.06). Satisfaction scores were higher (P < 0.01) for new prosthesis recipients, and lower at baseline for prosthesis abandoners compared with continued users (P = 0.03).

Conclusion:
Prosthesis abandonment appears to be predicated on dissatisfaction with the device, as well as less frequent/intense prosthesis use. These findings can be used to identify those at risk for prosthesis abandonment and improve their prosthesis experience.
Quantitative and Qualitative Analysis of Atherosclerotic Stenosis in the Middle Cerebral Artery Using High-Resolution Magnetic Resonance Imaging
Authors: Lin Guo-hui , Song Jian-xun , Fu Nian-xia , Huang Xu , Lu Hong-xia 
Published: October 2020

Purpose: We analyzed and compared the imaging characteristics of the vessel wall of the middle cerebral artery (MCA) in symptomatic and asymptomatic patients using a 3.0-T high-resolution magnetic resonance imaging (HR-MRI) protocol, including a 3-dimensional T1-sampling perfection with application-optimized contrasts using different flip angle evolutions sequence. Methods: Fifty-three patients with atherosclerotic stenosis of the MCA underwent 3.0-T HR-MRI examinations. The characteristics of atherosclerotic plaques in 53 patients (28 symptomatic, 25 asymptomatic) were analyzed, including plaque distribution and signal intensity. Plaque burden (PB), stenosis degree, and the remodeling index were measured and compared between symptomatic and asymptomatic patients. Results: The PB of the symptomatic group was significantly higher than that of the asymptomatic group ( P = .006), and moderate−severe stenosis was more common ( P = .01). The remodeling index of the symptomatic group was also lower ( P = .015) and negative remodeling (NR) was more common ( P = .043). Binary logistic regression analysis showed that stenosis degree was a risk factor in symptomatic patients (odds ratio = 135, P = .023). Conclusion: There is a trend that some characteristics of plaques and vessels, including the moderate-severe stenosis, larger PB, and NR, were observed more frequently among patients with symptomatic atherosclerotic stenosis of the MCA than among asymptomatic patients.
Short-term and 1-year outcome of patients’ with borderline personality admitted to a short-term recovery-oriented residential service
Authors: Sekharan Lokesh , Jagadheesan Karuppiah , Das Partha , Lakra Vinay , West Kim , Baldwin Miranda 
Published: October 2020

Objectives: Given the paucity of literature, this study investigated whether a prevention and recovery care (PARC) service supported recovery in patients with borderline personality disorder (BPD). Method: This retrospective study included patients with BPD who had their first (index) admission to North West PARC between 2011 and 2016. Patient medical records and the state-wide database were the sources of information. Results: Of the 67 patients included, over 70% attended group activities. All patients achieved their recovery goals, either fully or partially. Compared to admission, the frequency of substance use and the Health of the Nation Outcome Scale (HoNOS) scores at discharge were significantly less. A significantly smaller number of patients needed inpatient treatment during the 12 months following their PARC admission. Conclusion: The PARC service appears to promote clinical and psychosocial recovery in patients with BPD.
Escape the Simulation Room
Authors: Sanders Jennifer E. , Kutzin Jared , Strother Christopher G. 
Published: October 2020

Background. Healthcare simulations are used at most academic facilities to improve knowledge and performance on critical and key concepts and can also be used to enhance competency and teamwork. Group simulation scenarios often have individual team leaders, but these scenarios require a team to work together to efficiently care for the patient. Escape rooms can be utilized in healthcare as a fun educational activity to encourage teams to work together and think creatively to solve puzzles and challenges. One advantage of this type of activity in a healthcare setting is to dissolve any hierarchy amongst the team and build the confidence of novice or more passive participants. Escape rooms in a healthcare setting do not have to be medically themed to be effective, and rooms can be set up with minimal equipment. Aim. This article addresses the detailed steps required to set up a healthcare themed escape room that has been shown to work well. It is applicable to healthcare professionals and can be adapted for non-healthcare workers. Method. Based on the Escape Room video games and social activity phenomenon, teams compete to solve content-specific challenges to attain pieces of the final puzzle set forth by the instructors. Traditional quiz-type exercises, pictograms, and procedural based activities comprise the puzzles of the game. The first team to obtain all pieces of the final clue and put them together in the correct order in the shortest amount of time is deemed the winner. Gameplay is designed to conclude in approximately 20 minutes. Results and Conclusion. This game mimics interdisciplinary teamwork environments. Participating in interactive collaborative learning environments enhances the overall learning experience, allowing learners to apply knowledge.
Impact of dose-capping chemotherapy in concurrent chemoradiotherapy in rectal cancer patients
Authors: Yang Ran , Younis Moftah , Joseph Kurian , Ghosh Sunita , Nijjar Tirath , Severin Diane , Tankel Keith , Tamhane Yash , Fairchild Alysa , Spratlin Jennifer , Mulder Karen , Usmani Nawaid 
Published: October 2020

Introduction The study evaluated the effect of chemotherapy dose-capping on disease recurrence, toxicity and survival of rectal cancer patients treated with chemoradiotherapy (CRT). Methods 601 consecutive rectal cancer patients treated with concurrent CRT were retrospectively analysed. Dose-capped patients were defined as having a body surface area (BSA) ≥2.0 m2 and who received <95% full weight-based chemotherapy dose. Binary logistic regression was used to study the factors associated with the outcome variables (capped vs. uncapped). Kaplan-Meier estimation evaluated significant predictors of survival. Results The median follow-up time was 7.54 years. The rate of disease recurrence was significantly higher in dose-capped patients (35%) compared to those without dose-capping (24%, P = 0.016). The adjusted odds ratio for dose-capped patients experiencing recurrence was 1.64 compared to uncapped patients (95% CI, 1.10–2.43). Overall, dose-capped patients were less likely to experience significant toxicity requiring dose reduction and/or treatment break when compared to uncapped patients (15% and 28% respectively, P = 0.008).There was significant differences in PFS between capped and uncapped group (77% vs. 85%; P = 0.017). The 5-year OS in the capped group was 75.0%, and 80% in the uncapped group ( P = 0.149). Conclusions Rectal cancer patients treated with dose-capped CRT were at increased risk of disease recurrence. Patients dosed by actual BSA did experience excessive toxicity compared to dose-capped group. We recommend that chemotherapy dose-capping based on BSA should not be practiced in rectal cancer patients undergoing CRT.
Decreased antithrombin activity and inflammation in cats
Authors: Sun Prudence , Jeffery Unity 
Published: October 2020

Objectives The objective of this study was to determine if inflammatory markers are associated with antithrombin activity in cats. Methods For a retrospective population of 231 cats admitted to a referral hospital, antithrombin activity was classified as decreased (n = 77), intermediate (n = 97) or in the upper quartile (n = 57). Odds ratios (ORs) were calculated for an association between decreased or upper quartile activity and hypoalbuminemia, hyperfibrinogenemia, band neutrophilia and toxic change. Multiple logistic regression was performed to determine if an association between band neutrophilia and decreased antithrombin activity was independent of decreased hepatic synthesis, consumptive coagulopathy or protein loss. Results Cats with decreased antithrombin activity were more likely than cats with intermediate-to-upper quartile activity to have band neutrophilia (OR 2.85, P = 0.0050), hypoalbuminemia (OR 12.1, P <0.0001) or toxic neutrophils (OR 4.47, P <0.0001). Cats with antithrombin activity in the upper quartile were less likely than those with intermediate-to-low activity to have hypoalbuminemia (OR 0.31, P = 0.0023) or toxic neutrophils (OR 0.44, P = 0.033). In a regression model that included other mechanisms for decreased antithrombin, band neutrophilia remained associated with decreased antithrombin activity (adjusted OR 2.62, P = 0.013). Conclusions and relevance Contrary to previous studies suggesting antithrombin is a feline positive acute phase protein, this study demonstrates an association between decreased antithrombin activity and inflammation. Further studies are needed to determine the mechanistic basis of this association.
Assessment of copper accumulation in archived liver specimens from cats
Authors: Yamkate Punyamanee , Gold Randi M , Xenoulis Panagiotis G , Steiger Katja , Twedt David C , Suchodolski Jan S , Steiner Joerg M , Lidbury Jonathan A 
Published: October 2020

Objectives The aim of this study was to assess hepatic copper concentrations and zonal distribution in cat liver specimens. Methods For this study, 121 archived, formalin-fixed, paraffin-embedded liver specimens from cats were used. Tissue sections were stained for copper with rhodanine and scored from 0 (no copper accumulation) to 5 (panlobular copper accumulation). The tissue specimens were then deparaffinized and hepatic copper concentrations were measured using flame atomic absorption spectroscopy. Results Tissue samples were categorized into four groups based on histopathologic findings: (1) no significant histopathologic hepatic changes (n = 66); (2) hepatic steatosis (n = 18); (3) inflammatory or infectious disease (n = 24); and (4) neoplasia (n = 13). Of the 121 specimens, 13 (11%) stained positive for copper, with three having a score ⩾3. Thirty-seven specimens (31%) had copper concentrations above the reference interval ([RI] <180 µg/g dry weight liver). Copper concentrations in cats with hepatic inflammatory or infectious disease were significantly higher than cats with hepatic steatosis ( P = 0.03). Copper-staining score and concentration were positively correlated (rs = 0.46, P <0.001). Conclusions and relevance Despite the fact that 31% of specimens had copper concentrations above the RI, only 11% showed positive copper staining and only 2.5% had a score ⩾3. Our findings suggest that hepatic copper concentrations greater than the upper limit of the RI are relatively common in cats. Further studies to determine the factors that influence hepatic copper staining in cats and to establish contemporary RIs for hepatic copper in healthy cats are warranted.
The influence of dyadic congruence and satisfaction with dyadic type on patient self-care in heart failure
Authors: Bugajski Andrew , Buck Harleah , Zeffiro Valentina , Morgan Hailey , Szalacha Laura , Alvaro Rosaria , Vellone Ercole 
Published: October 2020

Abstract

Background
Chronic illness management is increasingly carried out at home by individuals and their informal caregivers (dyads). Although synergistic in concept, the nuances of dyadic congruence in caring for patients with heart failure are largely unexamined.

Aims
The purpose of this study was to examine the role of dyadic-type congruence on patient self-care (maintenance, symptom perception, and management) while controlling for actor and partner effects.

Methods
This secondary data analysis of 277 dyads consisted of a series of multilevel models to examine the impact of dyadic congruence on a patient’s self-care maintenance, symptom perception, and self-care management. Patient-level and caregiver-level data were input into each model simultaneously to account differential appraisals of factors related to the dyad.

Results
Bivariate analyses yielded dyad congruence which was associated with better patient self-care maintenance, symptom perception and management. However, after multilevel models were constructed, dyad congruence was found to be a significant predictor of patient’s symptom perception scores, but not self-care maintenance or management scores. Caregiver’s satisfaction with the dyad was differentially and significantly associated with self-care – it was inversely associated with patient self-care maintenance and positively associated with patient self-care management.

Conclusion
This is the first study, to our knowledge, reporting that congruence in heart failure dyads is associated with better patient symptom perception and this advances our prior hypothesis that dyad typologies could be used to predict patient self-care performance. Since symptom perception is the key to preventing heart failure exacerbation, screening heart failure patient and caregiver dyads for congruence is important in clinical settings.
Impact of Thoracic Endografting on the Hemodynamics of the Native Aorta: Pre- and Postoperative Assessments of Wall Shear Stress and Vorticity Using Computational Fluid Dynamics
Authors: Midulla Marco , Moreno Ramiro , Negre-Salvayre Anne , Beregi Jean-Paul , Haulon Stéphan , Loffroy Romaric , Dake Michael , Rousseau Hervé 
Published: October 2020

Purpose To quantify the hemodynamic consequences of thoracic endovascular aortic repair (TEVAR) by comparing the preoperative and postoperative wall shear stress (WSS) and vorticity profiles on computational fluid dynamics (CFD) simulations. Materials and Methods The pre- and postoperative computed tomography (CT) scans from 20 consecutive patients (median age 69 years, range 20–87) treated for different thoracic aortic pathologies (11 aneurysms, 5 false aneurysms, 3 penetrating ulcers, and 1 traumatic aortic rupture) were segmented to construct patient-specific CFD models using a meshless code. The simulations were run over the cardiac cycle, and the WSS and vorticity values measured at the proximal and distal landing zones were compared. Results The CFD runs provided 4-dimensional simulations of blood flow in all patients. WSS and vorticity profiles at the proximal landing zone (located in zones 0–3 in 15 patients) varied in 18 and 20 of the cases, respectively; WSS was increased in 11 cases and the vorticity in 9. Pre- and postoperative WSS median values were 4.19 and 4.90 Pa, respectively. Vorticity median values were 40.38 and 39.17 Hz, respectively. Conclusion TEVAR induces functional alterations in the native thoracic aorta, though the prognostic significance of these changes is still unknown. CFD appears to be a valuable tool to explore aortic hemodynamics, and its application in a larger series would help define a predictive role for these hemodynamic assessments.
Aneurysm Volumes After Endovascular Repair of Ruptured vs Intact Aortic Aneurysms: A Retrospective Observational Study
Authors: Oliveira-Pinto José , Soares-Ferreira Rita , Oliveira Nelson F. G. , Bouwens Elke , Bastos Gonçalves Frederico M. , Hoeks Sanne , Van Rijn Marie Josee , Ten Raa Sander , Mansilha Armando , Verhagen Hence J. M. 
Published: October 2020

Purpose To compare changes in abdominal aortic aneurysm (AAA) sac volume between endovascular aneurysm repairs (EVAR) performed for ruptured (rEVAR) vs intact (iEVAR) AAAs and to determine the impact of early volume shrinkage on future complications. Materials and Methods A retrospective analysis was performed of all patients undergoing standard infrarenal EVAR from 2002 to 2016 at a tertiary referral institution. Only patients with degenerative AAAs and with 30-day and 1-year computed tomography angiography (CTA) imaging were included. Early sac shrinkage was defined as a volume sac reduction >10% between the first (<30-day) and the 1-year CTA. The primary endpoint was to compare AAA sac volume changes between patients undergoing rEVAR (n=51; mean age 71.0±8.5 years; 46 men) vs iEVAR (n=393; mean age 72.3±7.5 years; 350 men). Results are reported as the mean difference with the interquartile range (IQR Q1, Q3). The secondary endpoint was freedom from aneurysm-related complications after 1 year as determined by regression analysis; the results are presented as the hazard ratio (HR) and 95% confidence interval (CI). Results At baseline, the rEVAR group had larger aneurysms (p<0.001) and shorter (p<0.001) and more angulated (p=0.028) necks. Aneurysm sac volume decreased more in the rEVAR group during the first year [−26.3% (IQR −38.8%, −12.5%)] vs the iEVAR group [−11.9% (IQR −27.5%, 0); p<0.001]. However, after the first year, the change in sac volume was similar between the groups [−3.8% (IQR −32.9%, 31.9%) for rEVAR and −1.5% (IQR −20.9%, 13.6%) for iEVAR, p=0.74]. Endoleak occurrence during follow-up was similar between the groups. In the overall population, patients with early sac shrinkage had a lower incidence of complications after the 1-year examination (adjusted HR 0.59, 95% CI 0.39 to 0.89, p=0.01). Conclusion EVAR patients treated for rupture have more pronounced aneurysm sac shrinkage compared with iEVAR patients during the first year after EVAR. Patients presenting with early shrinkage are less likely to encounter late complications. These parameters may be considered when tailoring surveillance protocols.