bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway
Authors: Pan Huayang , Liu Fukai , Wang Jinge , Zhao Ming , Wang Dawei , Jia Chen , Wang Tong , Chen Ze , Fan Yuying , Liang Desen , Meng Qinghui 
Published: March 2020

AbstractDihydromethysticin (DHM), a natural compound derived from Kava, has been reported to be effective against mental disorders and some malignant tumors. However, little is known about the inhibitory effect of DHM on colorectal cancer (CRC). First, we examined the impact of DHM on human colon cancer cell lines, which demonstrated that DHM inhibits proliferation, migration, and invasion and promotes apoptosis and cell cycle arrest in colon cancer cells in vitro. Using small hairpin RNA, we inhibited nucleotide‐oligomerization domain‐like receptor subfamily C3 (NLRC3)/phosphoinositide 3‐kinase (PI3K) pathway to elucidate the partial signaling of DHM‐mediated tumor suppression. Additionally, using an ectopic human CRC model, we verified whether DHM inhibits tumor growth and angiogenesis via the NLRC3/PI3K pathway in vivo. Overall, DHM showed an inhibitory effect on CRC by altering cell proliferation, migration, invasion, apoptosis, cell cycle, and angiogenesis, possibly via the NLRC3/PI3K pathway. Thus, DHM may be a promising candidate for CRC therapy.
Microbial survival and growth modeling in frame of nonsingular fractional derivatives
Authors: Ozarslan Ramazan 
Published: March 2020

In this article, the two‐parameter Weibull model (3) is considered for microbial survival curves by new fractional differential operators to analyze some microbial, common reasons of illnesses, and outbreaks, such as Salmonella spp. cocktail in ground turkey thigh, pork shoulder, and turkey breast at isothermal cooking conditions in 50°C, 54°C, 58°C, 62°C, and 66°C, then Listeria monocytogenes and Escherichia coli O157:H7 are considered in ground beef in the same thermal conditions. Results obtained with nonsingular fractional derivatives, including exponential decay and Mittag‐Leffler kernel, are analyzed comparatively with Caputo fractional and integer‐order derivatives for survival ratio of microbial cells. In the sequel, E. coli O157:H7 in ground beef, Salmonella typhimurium and S. enteritidis in boneless pork chops, and background flora in ground pork and at room temperature, 10°C, 7.2°C, and 4.4°C are considered for microbial growth curves by nonsingular fractional operators, and results obtained are compared with Caputo fractional and integer‐order derivatives. All results for advantage and disadvantage of Atangana‐Baleanu and Caputo‐Fabrizio fractional derivatives are discussed in detail.
2D Diffusion‐Ordered 1H‐NMR Spectroscopy Lipidomic Profiling after Oral Single Macronutrient Loads: Influence of Obesity, Sex, and Female Androgen Excess
Authors: Insenser María , Moncayo Samuel , Martínez‐García M. Ángeles , Fernández‐Durán Elena , Samino Sara , Álvarez‐Blasco Francisco , Luque‐Ramírez Manuel , Escobar‐Morreale Héctor F. 
Published: March 2020

ScopePostprandial dysmetabolism plays a major role in the pathogenesis of metabolic disorders such as obesity and the polycystic ovary syndrome (PCOS). The aim is to characterize the circulating lipoprotein particle profiles in response to oral glucose, lipid, and protein challenges.Methods and results17 women with PCOS, 17 control women, and 19 healthy men selected to have similar age and body mass index are studied. Blood samples are collected following the ingestion of 300 kcal in the form of glucose, lipids, or proteins, and they are submitted to two‐dimensional (2D) diffusion‐ordered 1H‐NMR spectroscopy. Regardless of macronutrient administered, the number of very low‐density (VLDL) particles increases whereas low density‐lipoprotein (LDL) decreases. High density‐lipoprotein (HDL) particles increase only after lipid ingestion. Obese subjects show an increase in the number of large VLDL particles and a decrease in large LDL particles, with a significant reduction in the average particle size of LDL. Patients with PCOS show a particularly unfavorably smaller LDL particle size response to oral lipid intake, regardless of obesity.ConclusionsOral macronutrient challenges induce immediate class‐specific postprandial changes in particle number and size of lipoproteins, with lipids inducing a more pro‐atherogenic lipoprotein profile compared to glucose and proteins, particularly in obese subjects and women with PCOS.
Use of mobile apps for controlling of the urinary incontinence: A systematic review
Authors: Leme Nagib Anita Bellotto , Riccetto Cássio , Martinho Natalia Miguel , Camargos Pennisi Pedro Rogério , Blumenberg Cauane , Paranhos Luiz Renato , Botelho Simone 
Published: March 2020

AbstractObjectiveThe primary objective was to evaluate the impact of app use on urinary incontinence control through pelvic floor muscle training when compared to the postal treatment plan. The secondary objectives were to evaluate how app use may affect the quality of life (QoL) of users and treatment adherence.Material and MethodsEight databases (PubMed, SciELO, Embase, Web of Science, LILACS, Open Gray, Open Thesis, and OATD) were used as research sources. The protocol was registered in PROSPERO (CRD 42020145709). Randomized controlled trials assessing urinary incontinence (UI) control with app use, with no restriction of year, language, and status of publication were included. The JBI Systematic Reviews Checklist for Randomized Controlled Trials assessed the risk of bias of the studies selected. The mean scores of QoL between the pre‐ and postintervention periods were compared through standardized mean differences, which were weighted according to the number of months between the two periods.ResultsOnly three studies met the eligibility criteria and were included. The methodological quality of the studies was from “low” to “moderate” risk of bias. The full sample included 203 patients with app‐based treatment e 203 controls of postal treatment. All studies showed the reduction of urinary symptoms. In addition, two studies showed a reduction of QoL scores specific for the condition, while one study presented increased scores.ConclusionReminder therapy seems to be a promising strategy for controlling UI.
Robust tensor completion using transformed tensor singular value decomposition
Authors: Song Guangjing , Ng Michael K. , Zhang Xiongjun 
Published: March 2020

SummaryIn this article, we study robust tensor completion by using transformed tensor singular value decomposition (SVD), which employs unitary transform matrices instead of discrete Fourier transform matrix that is used in the traditional tensor SVD. The main motivation is that a lower tubal rank tensor can be obtained by using other unitary transform matrices than that by using discrete Fourier transform matrix. This would be more effective for robust tensor completion. Experimental results for hyperspectral, video and face datasets have shown that the recovery performance for the robust tensor completion problem by using transformed tensor SVD is better in peak signal‐to‐noise ratio than that by using Fourier transform and other robust tensor completion methods.
Optimal maintenance planning in building retrofitting with interacting energy effects
Authors: Wang Bo , Xia Xiaohua , Cheng Zhongtao , Liu Lei 
Published: March 2020

SummaryThis paper extends a control system framework for the maintenance planning investment decision for building energy retrofitting. The interacting energy and reliability effects that are ignored by previous models are incorporated in the current study. A set of energy efficiency and population decay models with interacting parameters and decision variables are established, and a state‐space model with coupled nonlinear equations is obtained. The control objectives are maximizing the energy savings and financial paybacks with limited budget during a finite time period. An model predictive control (MPC) controller is designed for the problem. The interacting effects and effectiveness of the proposed approach are verified by the case study, where improvements from the modeling considering interaction are revealed.
Influence of short‐term dexamethasone on the efficacy of 177Lu‐PSMA‐617 in patients with metastatic castration‐resistant prostate cancer
Authors: Derlin Thorsten , Sommerlath Sohns Jan M. , Schmuck Sebastian , Henkenberens Christoph , von Klot Christoph A. J. , Ross Tobias L. , Bengel Frank M. 
Published: March 2020

AbstractBackground and AimCorticosteroids alone or in combination therapy are associated with favorable biochemical responses in metastatic castration‐resistant prostate cancer (mCRPC). We speculated that the intermittent addition of dexamethasone may also enhance the antitumor effect of radioligand therapy (RLT) with 177Lu‐prostate‐specific membrane antigen (PSMA)‐617.Patients and MethodsSeventy‐one patients with mCRPC were treated with 1 to 5 cycles of 177Lu‐PSMA‐617 (6.0‐7.4 GBq per cycle) at 6 to 8 weeks intervals. Based on the clinical decision (eg, in the case of vertebral metastases), 56% of patients received 4 mg of dexamethasone for the first 5 days of each cycle. Biochemical response rates, PSA decline and progression‐free survival (PFS) were analyzed after one, three, and five cycles of RLT.ResultsPSA response rates were not significantly different between patients receiving 177Lu‐PSMA‐617 plus dexamethasone and those receiving 177Lu‐PSMA‐617 alone after one, three, and five cycles (33% vs 39%, P = .62; 45% vs 45%, P = 1.0; and 38% vs 42%, P = .81). However, there was a nonsignificant trend for a more pronounced PSA decline in patients with bone metastases receiving adjunct dexamethasone (−21% ± 50% vs +11% ± 90%, P = .08; −21% ± 69% vs +22% ± 116%, P = .07; −13% ± 76% vs +32% ± 119%, P = .07). Median PFS tended to be longer in patients with bone metastases receiving 177Lu‐PSMA‐617 plus dexamethasone (146 vs 81 days; hazard ratio: 0.87 [95% confidence interval: 0.47‐1.61]; P = .20). Multiple regression analysis showed that age (P = .0110), alkaline phosphatase levels (P = .0380) and adjunct dexamethasone (P = .0285) were independent predictors of changes in PSA in patients with bone metastases.ConclusionsWe observed high response rates to 177Lu‐PSMA‐617 RLT in men with mCRPC. The short‐term addition of dexamethasone to 177Lu‐PSMA‐617 had no striking antitumor effect but might enhance biochemical responses in patients with bone metastases. Future trials are warranted to test this hypothesis in a prospective setting.
Wearable and Ultrasensitive Strain Sensor Based on High‐Quality GaN pn Junction Microwire Arrays
Authors: Cheng Shiduo , Han Sancan , Cao Ziyang , Xu Chenchao , Fang Xiaosheng , Wang Xianying 
Published: March 2020

AbstractWith the rapid growth in wearable electronics sensing devices, flexible sensing devices that monitor the human body have shown great promise in personalized healthcare. In the study, high‐quality GaN pn junction microwire arrays with different aspect ratios and large‐area uniformity are fabricated through an easy, repeatable fabrication process. The piezoelectric coefficient (d33) of GaN pn junction microwire arrays increases from 7.23 to 14.46 pm V−1 with the increasing of the aspect ratio, which is several times higher than that of GaN bulk material. Furthermore, flexible ultrasensitive strain sensor based on GaN microwires with the highest d33 is demonstrated to achieve the maximum open circuit voltage of 10.4 V, and presents excellent durability with stable output signals over 10 000 cycles with a response time of 50 ms. As a flexible and wearable sensor attached to the human skin, the GaN microwire pn junction arrays with such a high degree of uniformity can precisely monitor subtle human pulse and motions, which show great promise in future personalized healthcare.
Safety‐by‐Design of Metal Oxide Nanoparticles Based on the Regulation of their Energy Edges
Authors: Feng Yanlin , Chang Yun , Xu Keqiang , Zheng Runxiao , Wu Xiaqing , Cheng Yan , Zhang Haiyuan 
Published: March 2020

AbstractThe safety of metal oxide (MOx) nanoparticles (NPs) has been highly concerned because of their wide application and potential toxicological injury. The safe‐by‐design strategy is usually developed to make safer MOx NPs based on regulation of their physicochemical properties. In the present study, manganese oxide (Mn3O4) NPs, as a representative of insoluble toxic MOx NPs, are doped with a series of transition metal to regulate their conduction band energy (Ec) out of biological redox potential range (BRPR) or Fermi energy (Ef) far away from valence band energy (Ev), aiming at completely eliminating the toxicity or significantly reducing the toxicity. It is found that all these M‐doping cannot move Ec of Mn3O4 NPs out of the BRPR but zinc (Zn)‐, copper (Cu)‐, and chromium (Cr)‐doping do move Ef far away from Ev, where Zn‐doping results in the largest |Ef − Ev| value. Various abiotic, in vitro and in vivo assessments reveal that Zn‐, Cu‐, and Cr‐doped Mn3O4 NPs can generate lower amount of •OH and trigger weaker injury than Mn3O4 NPs, where Zn‐doped Mn3O4 NPs show the lowest toxicity. Regulating Ef far away from Ev becomes a feasible safe‐by‐design approach to achieve safe MOx NPs.
Development of Resistant Starch Film Coated Microparticles for an Oral Colon‐Specific Drug Delivery
Authors: Khan Anum , Bibi Amna , Ali Huma , ur Rehman Asim , Qindeel Maimoona , Irfan Muhammad , Shah Aamer Ali , Badshah Malik , Hasan Fariha , Khan Samiullah 
Published: March 2020

AbstractIn this study, novel enzymatically modified resistant starch type III (EM‐RSIII) derived drug loaded microspheres are developed for oral colon‐specific delivery of ciprofloxacin HCl, used as a model drug. EM‐RS III is enzymatically prepared using starch hydrolyzing enzymes amylase and pullulanase. The prebiotic effect of EM‐RSIII is successfully scrutinized for promoting the growth of probiotic bacteria, for example, Lactobacillus reuteri. Drug‐loaded microspheres are synthesized from the EM‐RSIII through a single emulsion evaporation method. The pH‐sensitive drug‐loaded microspheres are characterized through scanning electron microscopy, X‐ray diffraction, and Fourier‐transform infrared spectroscopy. Release studies confirm the stability of drug‐loaded microspheres at acidic pH while sustained release is observed at pH 7.8 demonstrating a site‐specific delivery of drug to the colon. The in vitro release mechanism of drug is evaluated using various kinetic models. The study also reveals that EM‐RSIII‐derived microspheres are biodegradable and are degraded by the natural microflora of the colon, which is indicated by stimulating growth of probiotic bacteria. The microspheres are exploited as drug carriers for the colon‐specific release of ciprofloxacin HCl, and its encapsulation is further confirmed from the antibacterial activity.
Principal interacting orbital: A chemically intuitive method for deciphering bonding interaction
Authors: Zhang Jing‐Xuan , Sheong Fu Kit , Lin Zhenyang 
Published: March 2020

AbstractModular bonding picture is a central part of chemical understanding as exemplified by the wide usage of Lewis structure as a chemical language to describe molecular electronic structures. A chemically intuitive bonding picture requires the descriptors to be localized and transferable. Molecular orbitals directly derived from quantum calculations are too delocalized to interpret in this regard, hence many efforts have been devoted to the development of bonding analysis methods. After a brief overview of various bonding analysis methods, this review outlines the framework of principal interacting orbital (PIO) analysis and presents its role in recovering intuitive chemical concepts and producing modular bonding pictures. The PIO analysis identifies the most important fragment orbitals that are involved in fragment interactions and characterizes a one‐to‐one orbital interaction pattern that underlies a unique set of bonding and anti‐bonding orbitals derived from pairwise orbital interactions between two fragments. By making use of the principal component analysis (PCA), PIO analysis can effectively combine complex delocalized interaction patterns involved in numerous molecular orbitals into a handful of localized PIOs to provide easily interpretable results with intimate connection to localized chemical concepts, while maintaining necessary delocalized features when dealing with systems that involve mutlicentered interactions such as cluster compounds and various reactions. Such adaptability guarantees the robustness of PIO analysis with respect to change of substituents and the transferability of obtained PIOs across different systems.This article is categorized under:
Structure and Mechanism > Molecular Structures
Assessment of microbial contamination levels of water in hemodialysis centers in Baghdad, Iraq
Authors: Humudat Yasamen R. , Al‐Naseri Saadi K. , Al‐Fatlawy Yaaroub F. 
Published: March 2020

AbstractMonitoring water quality in hemodialysis systems is extremely important to maintain adequate quality services for patients suffering from kidney failure. This work aims to examine and evaluate bacteriological characteristics and endotoxin contamination levels in hemodialysis water produced in dialysis centers. Forty‐eight water samples were collected and analyzed from four major hospitals in Baghdad for one year to evaluate seasonal effects. The analysis included the determination of total heterotrophic bacteria using the pour plate method, identification of bacterial isolate using the Vitek2 compact instrument, and the determination of endotoxins levels using Limulus amebocyte lysate (LAL) method. In addition, tap water samples (a source for the hemodialysis water) were also examined bacteriologically. Results showed that 44% of the tested samples for bacterial levels are higher than the maximum value of (100 CFU/ml) set out by the international standards. Endotoxin values for these centers fluctuated during the study period, and 44% of them exceeded the international standards (>0.25 EU/ml). These results call for applying improved technology to modify the existing water treatment units for better control and for national standardization of the microbiological quality of hemodialysis water.Practitioner points

Four hemodialysis centers were assessed by measuring the bacteriological and endotoxins levels of their feed and product water.

Product water showed elevated levels of bacteria that exceeded the international guideline value of 100 CFU/ml.

Most of the identified bacterial species were Gram‐negative that arise the possibility of contributing to endotoxin generation.

Product water showed fluctuated values of endotoxins. About 44% of the measured samples were higher than the international guideline values of 0.25 EU/ml.
Bayesian spatial and spatiotemporal models based on multiscale factorizations
Authors: Ferreira Marco A. R. 
Published: March 2020

AbstractWe review the literature on spatial and spatiotemporal models based on spatial multiscale factorizations. Specifically, we review models based on wavelets and Kolaczyk–Huang factorizations for Gaussian and Poisson data. These multiscale models decompose spatial and spatiotemporal datasets into many small components, called multiscale coefficients, at multiple levels of spatial resolution. Then analysis proceeds independently for each multiscale coefficient. After that, aggregation equations are used to coherently combine the analyses from the multiple multiscale coefficients to obtain a statistical analysis at the original resolution level. The computational cost of such analysis grows linearly with sample size. Furthermore, computations for these models are scalable, parallelizable, and fast. Therefore, these multiscale models are tremendously useful for the analysis of massive spatial and spatiotemporal datasets.This article is categorized under:Statistical Learning and Exploratory Methods of the Data Sciences > Modeling MethodsStatistical Models > Bayesian ModelsData: Types and Structure > Image and Spatial Data
Emerging Themes in Disciplinary Based Leadership Education
Authors: Sowcik Matthew , Komives Susan R. 
Published: March 2020

AbstractThis chapter uses the categories of the International Leadership Association's (2009) Guiding Questions (i.e., context, conceptual framework, content, teaching and learning, and outcomes and assessment) to present themes about leadership education among academic disciplines. Recommendations for the development of leadership education in academic disciplines are included.
Geodetic Monitoring of the Variable Surface Deformation in Latin America
Authors: Sánchez Laura , Drewes Hermann 
Published: March 2020

AbstractBased on 24 years of high-level GNSS data analysis, we present a sequence of crustal deformation models showing the varying surface kinematics in Latin America. The deformation models are inferred from GNSS station horizontal velocities using a least-squares collocation approach with empirically determined covariance functions. The main innovation of this study is the assumption of continuous surface deformation. We do not introduce rigid microplates, blocks or slivers which enforce constraints on the deformation model. Our results show that the only stable areas in Latin America are the Guiana, Brazilian and Atlantic shields; the other tectonic entities, like the Caribbean plate and the North Andes, Panama and Altiplano blocks are deforming. The present surface deformation is highly influenced by the effects of seven major earthquakes: Arequipa (Mw8.4, Jun 2001), Maule (Mw8.8, Feb 2010), Nicoya (Mw7.6, Sep 2012), Champerico (Mw7.4, Nov 2012), Pisagua (Mw8.2, Apr 2014), Illapel (Mw8.3, Sep 2015), and Pedernales (Mw7.8, Apr 2016). We see very significant kinematic variations: while the earthquakes in Champerico and Nicoya have modified the aseismic deformation regime in Central America by up to 5 and 12 mm/a, respectively, the earthquakes in the Andes have resulted in changes of up to 35 mm/a. Before the earthquakes, the deformation vectors are roughly in the direction of plate subduction. After the earthquakes, the deformation vectors describe a rotation counter-clockwise south of the epicentres and clockwise north of the epicentres. The deformation model series reveals that this kinematic pattern slowly disappears with post-seismic relaxation. The numerical results of this study are available at https://doi.pangaea.de/10.1594/PANGAEA.912349 and https://doi.pangaea.de/10.1594/PANGAEA.912350.
Towards the Realization of the International Height Reference Frame (IHRF) in Argentina
Authors: Tocho Claudia Noemi , Antokoletz Ezequiel Dario , Piñón Diego Alejandro 
Published: March 2020

AbstractThis paper describes a practical implementation of the International Height Reference System (IHRS) in Argentina. The contribution deals with the determination of potential values W(P) at five Argentinean stations proposed to be included in the reference network of the International Height Reference Frame (IHRF). All sites are materialized with GNSS stations of the Argentine continuous satellite monitoring network and most of them are included in the SIRGAS Continuously Operating Network. Not all the stations are connected to the National Vertical Reference System 2016 and most of them are near to an absolute gravity station measured with an A10 gravimeter.This paper also discusses the approach for the computation of W(P) at the IHRF stations using the Argentinean geoid model GEOIDE-Ar 16 developed by the Instituto Geográfico Nacional, Argentina together with the Royal Melbourne Institute of Technology (RMIT) University, Australia using the remove-compute-restore technique and the GOCO05s satellite-only Global Gravity Model. Then, geoid undulations (N) were transformed to height anomalies (ζ) in order to infer W(P) at the stations located on the Earth’s surface. The transformation from N to ζ must be consistent with the hypothesis used for the geoid determination. Special emphasis is made on the standards, conventions and constants applied.