bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a Novel Electromagnetic Rewarming Technology for the Cryopreservation of Stem Cells with Large Volume
Authors: Ren Shen , Shu Zhiquan , Pan Jiaji , Peng Ji , Wang Junlan , Zhao Chunhua , Gao Dayong 
Published: November 2020

Applications of stem cells have been playing significant roles in scientific and clinical settings in the last few decades. The foundation of these approaches is successful cryopreservation of stem cells for future use. However, so far we can only cryopreserve stem cell suspension of small volumes in the order of 1 mL mostly due to the lack of an effective rewarming technique. Rapid and uniform rewarming has been approved to be beneficial, and sometimes, indispensable for the survival of cryopreserved stem cells, inhibiting ice recrystallization or devitrification. Unfortunately, the conventional water bath thawing method failed in providing the rapid and uniform rewarming. The conversion of electromagnetic (EM) energy into heat provides a possible solution to this problem. This chapter will focus on (1) analysis of the combined EM and heat transfer phenomenon in the rewarming of a biospecimen, (2) numerical investigation of the rewarming system, (3) practical setup of an EM resonance system, and (4) test of heating performance with large volume of cells.
Ocena stopnje reprodukcije okužbe in deleža okuženih z virusom SARS-CoV-2 v Sloveniji
Authors: Manevski Damjan , Pohar Perme, PhD Maja , Blagus Rok 
Published: November 2020

Izhodišče: v članku ocenjujemo vpliv uveljavljenih ukrepov za obvladovanje epidemije okužbe z virusom SARS-CoV-2 na stopnjo reprodukcije okužbe z virusom in delež okuženih za Slovenijo.
Metode: uporabimo Bayesov model, ki predpostavlja enako učinkovitost ukrepov v različnih državah in je zgrajen na podlagi podatkov o številu umrlih za 12 (model A) oz. 10 evropskih držav (izločeni Španija in Italija, model B).
Rezultati: ocenjena stopnja reprodukcije v Sloveniji po sprejetih ukrepih je 0,6; pod 1 je celoten 95 % kredibilni interval [0,3 - 0,9]. Če pri gradnji modela izločimo Italijo in Španijo (model B), je ocenjena stopnja reprodukcije v Sloveniji po sprejetih ukrepih 0,8 (95 % kredibilni interval [0,5 - 1,2]). Ocenjeni delež okuženih v Sloveniji je manjši od enega odstotka (0,53 [0,23 - 1,01] % pri modelu A in 0,66 [0,26 - 1,45] % pri modelu B), uradno število potrjenih primerov pa podcenjuje dejansko število za približno faktor 10.
Zaključek: dosedanji sprejeti ukrepi so bili uspešni, saj menimo, da je trenutna stopnja reprodukcije virusa SARS-CoV-2 pod 1. Pri sproščanju ukrepov je smiselno počakati vsaj 2 tedna, saj ocenjujemo, da to pomeni vsaj dodatnih 5 tednov zamika do ponovnih zaostritev.
Deuil compliqué selon les cultures : défis diagnostiques et limites des classifications internationales
Authors: Ben-Cheikh Imen , Rachédi Lilyane , Rousseau Cécile 
Published: November 2020

Le deuil compliqué demeure un sujet à controverse. Bien que ce concept se retrouve dans de nombreuses cultures, peu d’études scientifiques abordent les complications du deuil dans une perspective transculturelle. Cet article, qui repose sur la présentation d’un cas clinique et une revue de la littérature, décrit les particularités du deuil selon les cultures et en contexte d’immigration. Il offre un regard transculturel sur le deuil dit compliqué et discute les limites des classifications internationales pour diagnostiquer les complications d’un deuil selon les cultures. En influençant le processus même du deuil, ses manifestations cliniques et ses complications éventuelles, la culture et la religion peuvent rendre complexe la distinction entre un deuil normal et un deuil compliqué en contexte interculturel. Le concept de deuil compliqué est discuté en mettant en avant l’importance d’une approche culturellement sensible pour en permettre une évaluation clinique appropriée. Nous soulignons la question centrale du sens donné à la mort et aux symptômes vécus en période de deuil, et la pertinence d’un regard critique sur le risque de médicalisation du deuil et les limites des classifications internationales, DSM-5 et CIM-11. Les nouvelles nosographies devraient bénéficier d’une plus grande précision concernant les complications du deuil selon les cultures non occidentales, en incluant des déterminants spécifiques liés à la culture, comme les systèmes de croyances entourant une « mauvaise mort » et les interprétations culturelles des rêves où figure une personne défunte.
Le risque de contagion suicidaire lié à l’identification aux personnages de films et de séries
Authors: Gauld Christophe , Notredame Charles-Edouard 
Published: November 2020

La représentation cinématographique (incluant les séries télévisées) d’un suicide pourrait influencer le taux de suicide par le biais d’un phénomène d’identification au personnage visualisé à l’écran. Lorsqu’elle conduit à l’imitation du geste suicidaire, cette projection identificatoire, par contagion suicidaire, est nommée « effet Werther » (EW); son corollaire, pour prévenir le phénomène suicidaire, est « l’effet Papageno » (EP). Le présent article analyse le rôle de l’identification au cinéma dans l’appropriation émotionnelle et cognitive des scènes de suicide, et son implication dans les EW et EP. Pour ce faire, nous nous sommes appuyés sur une bibliographie scientifique couvrant trois domaines : la contagion suicidaire, les études en communication et les études sur le cinéma.
PORTRAIT DE LA MÈRE EN RABAT-JOIE
Authors: Boisclair Isabelle 
Published: November 2020

Le temps d’un été, celui marquant son passage du primaire au secondaire, à la fin des années soixante, la narratrice de La soeur de Judith de Lise Tremblay observe le monde autour d’elle, dans un quartier de Chicoutimi. Les « explosions » de la mère ont beau être tempérées par le père, elles sont source de honte pour la jeune fille. Mais qu’est-ce qui les suscite ? En se penchant sur les motifs qui provoquent les colères de la mère, il apparaît que celles-ci sont toutes liées au statut des femmes, subordonnées dans le mariage. Le roman figure ainsi la mère en « rabat-joie féministe » (Ahmed) qui s’élève contre la mystique féminine (Friedan) dont sont nourries les femmes de cette époque qui s’éveille à la modernité. Au seuil de cette nouvelle temporalité, de nouveaux possibles féminins se dressent devant la jeune fille.
Freeze-like responses to pain in humans and its modulation by social context
Authors: Karos Kai , Meulders Ann , Leyssen Tine , Vlaeyen Johan W. 
Published: November 2020

BackgroundMaladaptive defensive responses such as excessive avoidance behavior have received increasing attention as a main mechanism for the development and maintenance of chronic pain complaints. However, another defensive response which is commonly studied in animals as a proxy for fear is freezing behavior. No research to date has investigated human freezing behavior in the context of pain. In addition, there is an increasing realization that social context can affect pain-relevant processes such as pain experience and pain behavior but less is known about the effects of social context on defensive responses to pain. Hence, this study investigated freezing behavior and facial pain expression in the context of pain, and their modulation by social context.MethodsHealthy, pain-free participants (N = 39) stood on a stabilometric force platform in a threatening or safe social context, which was manipulated using angry or happy facial stimuli. In some trials, an auditory cue (conditioned stimulus; CS) predicted the occurrence of painful electrocutaneous stimulus (unconditioned stimulus; pain-US). We assessed body sway (an index of freezing), heart rate, facial pain expression, self-reported pain intensity, unpleasantness, and pain-US expectancy during the CS and the context alone (no CS).ResultsThe results were mixed. Neither the anticipation of pain, nor social context affected body sway. Heart rate and painful facial expression were reduced in the threatening social context at high anxiety levels. A threatening social context also elicited higher pain-US expectancy ratings. In sum, a threatening social context increases the expectation of pain, but reduces the facial expression of pain and lowers heart rate in highly anxious individuals.
Wake‐Up Effect in HfO2‐Based Ferroelectric Films
Authors: Jiang Pengfei , Luo Qing , Xu Xiaoxin , Gong Tiancheng , Yuan Peng , Wang Yuan , Gao Zhaomeng , Wei Wei , Tai Lu , Lv Hangbing 
Published: November 2020

AbstractHfO2‐based ferroelectric materials are promising candidates for next‐generation nonvolatile memories. Since the first report on Si‐doped HfO2 ferroelectric thin film in 2011, it has been confirmed that various dopants can induce ferroelectricity in HfO2‐based films, and the “wake‐up” effect in HfO2 films with different dopants deposited by different processes has been studied extensively. Recent developments in the wake‐up effect of doped HfO2‐based films are presented. Aside from the differences between the various ferroelectric materials and their deposition methods, the electrodes used in a ferroelectric capacitor, which determine the nature of the interface between the electrode and the ferroelectric layer, can strongly influence the characteristics of the wake‐up effect. The rate of variation of the remanent polarization shows certain trends with different dopants. Based on the wake‐up mechanisms, many methods to optimize and control this effect are presented in this letter. Until now, the reported mechanism explanations of the wake‐up effect all aimed at one type of specific dopant or deposition technique, but can't systematically interpret why the root causes might be different with different dopants and deposition processes. There is also a lack of in‐depth research on the effects of interfacial layer with respect to different electrode material.
Preparation of conductive polylactic acid/high density polyethylene/carbon black composites with low percolation threshold by locating the carbon black at the Interface of co‐continuous blends
Authors: Luo Yue , Xiong Su‐Ya , Zhang Feng , He Xiao‐Xiang , Lu Xiang , Peng Rui‐Tao 
Published: November 2020

AbstractIn the current study, polylactic acid/high density polyethylene/carbon black (PLA/HDPE/CB) composites are prepared via a two‐step method. A double percolation network with co‐continuous structure and filler distribution at the interface is constructed to design conductive polymer composites with low percolation threshold. The controllable distribution of CB at the interface is achieved by appropriate processing procedures involved mixing sequence and mixing time by taking advantage of the migration of CB from the unfavorable PLA phase to the favorable HDPE phase. Morphology characterization reveals that when the mixing time of the added HDPE is 3 min, the formation of co‐continuous structure of PLA/HDPE (60/40, w/w) is observed, and CB particles migrate to the co‐continuous interface. The electrical conductivity measurement shows that such double percolation conductive network reduces the percolation threshold of PLA/HDPE/CB to 2.42 wt%. The rheological property proves the establishment of particle percolation network, and the rheological percolation threshold is determined as 1.20 wt%. The prepared PLA/HDPE/CB composite by the two‐step method displays a notably low percolation threshold than that prepared by one‐step simultaneous mixing. Moreover, this strategy presents a high potential application in the fabrication of conductive polymer composites involving other miscible multiphase systems.
Thin wall injection‐overmoulding of polyamide 6/polypropylene multilayer parts: PA6/PP‐g‐ma interfacial adhesion investigations
Authors: Lafranche Eric , Macedo Sandra , Ferreira Pedro , Martins Carla I. 
Published: November 2020

AbstractThis work investigates the interfacial adhesion of PA6/PP‐g‐MA in a thin‐walled multilayer part obtained by injection overmoulding. This process is a good solution to the need of weight reduction for the sustainable and economic growth of food packaging. A rigid plastic food package is a complex multilayer structure obtained from the association of polymers with different properties to achieve good barrier, environment, or thermo‐mechanical performance. The present study aims to obtain a complete understanding of the interfacial adhesion of PA6/PP‐g‐MA interface in a three‐layer PA6/sealant/PP assembly through microscopy analysis, mechanical characterization, and inter‐diffusion models. Optical microscopy, XPS, and AFM analyses showed the presence of a copolymer interphase. This layer is greatly dependent on the holding pressure applied, which revealed to be the key parameter to obtain the best results in terms of failure strength. A better interface wettability improves the inter‐diffusion distance and thus chemical grafting efficiency. Other interface improvements were achieved by the addition of EVA in the PP‐g‐MA layer. The lowest viscosity of the EVA dispersed phase has led to a fully cohesive failure due to an interface diffusion efficiency. The presence of EVA increased more than 80% of the peeling performance of the assemblies.
Transmissible cancers in mammals and bivalves: How many examples are there?
Authors: Dujon Antoine M. , Bramwell Georgina , Roche Benjamin , Thomas Frédéric , Ujvari Beata 
Published: November 2020

AbstractTransmissible cancers are elusive and understudied parasitic life forms caused by malignant clonal cells (nine lineages are known so far). They emerge by completing sequential steps that include breaking cell cooperation, evade anti‐cancer defences and shedding cells to infect new hosts. Transmissible cancers impair host fitness, and their importance as selective force is likely largely underestimated. It is, therefore, crucial to determine how common they might be in the wild. Here, we draw a parallel between the steps required for a transmissible cancer to emerge and the steps required for an intelligent civilisation to emerge in the Milky Way using a modified Drake equation. Using numerical analyses, we estimate the potential number of extant marine and bivalve species in which transmissible cancers might exist. Our results suggest that transmissible cancers are more common than expected, and that new lineages can be found by screening a large number of species.
Molecular dynamic simulations of diacridine binding to DNA: Indications that C6 diacridine can bisintercalate spanning two base pairs
Authors: Rowell Keiran N. , Thomas Donald S. , Ball Graham E. , Wakelin Laurence P. G. 
Published: November 2020

AbstractDimers of 9‐aminoacridine linked via the 9‐amino group with polymethylene chains, termed diacridines, are known to bisintercalate into DNA when the linker comprises 6 or more methylene units. There are no literature reports of crystal or NMR solution structures for bisintercalated diacridine‐DNA complexes, and the issue of the structure of the C6 ([CH2]n linker where n = 6) diacridine complex remains unresolved. Previously, based on simple geometric considerations, it was proposed that C6 diacridine could only span a single base pair, which requires that its bifunctional reaction violates the widely‐observed “neighbor exclusion principle” where bound intercalators are separated by at least 2 base pairs. Here we have explored the structure of diacridine‐DNA complexes using unrestrained molecular dynamics in explicit solvent using the parmbsc0 forcefield in AMBER14. We studied the C4 to C8 dimers, intercalated via both the minor and major DNA grooves, to a variety of nucleotide sequences. We find that C6, C7, and C8 diacridine are able to form 2 base pair bisintercalated complexes from either groove, whereas the C4 and C5 homologues cannot. We conclude that C6 diacridine does have the capacity to bisintercalate without violating neighbor exclusion, and that the previous proposed binding model needs revision.
Simultaneous occurrence of Pyoderma Gangrenosum and Palmoplantar Pustular Psoriasis: Is it an association or coincidental findings?
Authors: Pukar Chapagain , Sudha Agrawal , Punam Paudyal 
Published: November 2020

AbstractPyoderma Gangrenosum and Palmoplantar Pustular Psoriasis share the common pathogenesis, histological features, age group, and female preponderance that suggests a common etiological link.
Transient spontaneous chylothorax presented with neck pain and swelling in a patient with latent TB: Case report
Authors: Almasri Hussam , Hammamy Riyadh , Alamami Ans , Khalid Shariff Mohamed 
Published: November 2020

AbstractThe aim of this case report is to raise awareness about self‐limited spontaneous chylothorax. Extensive workup for small nontraumatic chylothorax may not be justified.
Hypocalcemia as an important differential diagnosis in patients suffering from stridor following thyroidectomy
Authors: Nitschke Christine , Ghadban Tarek , Izbicki Jakob , Grotelüschen Rainer 
Published: November 2020

AbstractIt is essential to consider hypocalcemia as a cause of stridor, especially following postoperative thyroidectomy, as hypocalcemia secondary to hypoparathyroidism is an important differential diagnosis. Advances in intraoperative technology to optimize the vascularization of the parathyroid glands can help to predict and prevent patients from a postoperative hypoparathyroidism.
Promoting Photocatalytic Hydrogen Evolution Activity of Graphitic Carbon Nitride with Hole‐Transfer Agents
Authors: Indra Arindam , Beltrán‐Suito Rodrigo , Müller Marco , Sivasankaran Ramesh P. , Schwarze Michael , Acharjya Amitava , Pradhan Bapi , Hofkens Johan , Brückner Angelika , Thomas Arne , Menezes Prashanth W. , Driess Matthias 
Published: November 2020

AbstractVisible light‐driven photocatalytic reduction of protons to H2 is considered a promising way of solar‐to‐chemical energy conversion. Effective transfer of the photogenerated electrons and holes to the surface of the photocatalyst by minimizing their recombination is essential for achieving a high photocatalytic activity. In general, a sacrificial electron donor is used as a hole scavenger to remove photogenerated holes from the valence band for the continuation of the photocatalytic hydrogen (H2) evolution process. Here, for the first time, the hole‐transfer dynamics from Pt‐loaded sol−gel‐prepared graphitic carbon nitride (Pt‐sg‐CN) photocatalyst were investigated using different adsorbed hole acceptors along with a sacrificial agent (ascorbic acid). A significant increment (4.84 times) in H2 production was achieved by employing phenothiazine (PTZ) as the hole acceptor with continuous H2 production for 3 days. A detailed charge‐transfer dynamic of the photocatalytic process in the presence of the hole acceptors was examined by time‐resolved photoluminescence and in situ electron paramagnetic resonance studies.
Fixation of CO2 into Cyclic Carbonates by Halogen‐Bonding Catalysis
Authors: Yan Rui , Chen Kai , Li Zhenjiang , Qu Yuanyuan , Gao Luoyu , Tong Haoying , Li Yongqiang , Li Jie , Hu Yongzhu , Guo Kai 
Published: November 2020

AbstractHalogen bonding, parallel to hydrogen bonding, was introduced into the catalytic cycloaddition of carbon dioxide into epoxide (CCE) reactions. A series of halogen‐bond donor (XBD) catalysts of N‐iodopyridinium halide featured with N−I bond were synthesized and evaluated in CCE reactions. The optimal XBD catalyst, 4‐(dimethylamino)‐N‐iodopyridinium bromide ([DMAPI]Br), under screened conditions at 100 °C, ambient pressure, and 1 mol % catalyst loading, realized 93 % conversion of styrene oxide into cyclic carbonate in 6 h. The substrate scope was successfully extended with excellent yields (mostly ≥93 %) and quantitative selectivity (more than 99 %). 1H NMR spectroscopy of the catalyst [DMAPI]Br on substrate epoxide certified that the N−I bond directly coordinated with the epoxide oxygen. A plausible mechanism of halogen‐bonding catalysis was proposed, in which the DMAPI cation functioned as halogen‐bond donor to activate the epoxide, and the counter anion bromide attacked the methylene carbon to initiate the ring‐opening of the epoxide. CCE reactions promoted by N‐iodopyridinium halide, exemplify a first case of halogen‐bonding catalysis in epoxide activation and CO2 transformation.
A new tale of lost tails: Correlates of tail breakage in the worm lizard Amphisbaena vermicularis
Authors: Guedes Jhonny J. M. , Costa Henrique C. , Moura Mario R. 
Published: November 2020

AbstractPredator–prey interactions are important evolutionary drivers of defensive behaviors, but they are usually difficult to record. This lack of data on natural history and ecological interactions of species can be overcome through museum specimens, at least for some reptiles. When facing aggressive interactions, reptile species may exhibit the defensive behavior of autotomy by losing the tail, which is also known as “urotomy”. The inspection of preserved specimens for scars of tail breakage can reveal possible ecological and biological correlates of urotomy. Herein, we investigated how the probability of urotomy in the worm lizard Amphisbaena vermicularis is affected by sex, body size, temperature, and precipitation. We found higher chances of urotomy for specimens with larger body size and from localities with warmer temperatures or lower precipitation. There was no difference in urotomy frequency between sexes. Older specimens likely faced – and survived – more predation attempts through their lifetime than smaller ones. Specimens from warmer regions might be more active both below‐ and aboveground, increasing the odds to encounter predators and hence urotomy. Probability of urotomy decreased with increased precipitation. Possibly, in places with heavier rainfall worm lizards come more frequently to the surface when galleries are filled with rainwater, remaining more exposed to efficient predators, which could result in less survival rates and fewer tailless specimens. This interesting defensive behavior is widespread in squamates, but yet little understood among amphisbaenians. The novel data presented here improve our understanding on the correlates of tail breakage and help us to interpret more tales of lost tails.
Supplementation with Docosahexaenoic Acid and Vitamin E Improves Hepatic Triglyceride Accumulation Induced by High‐Fat Diet in Mice
Authors: Yuan Gaofeng , Xu Mengmeng , Tan Meijuan , Dong Jian , Chen Xiaoe 
Published: November 2020

AbstractThe study aims to investigate the effect of combined supplementation with docosahexaenoic acid (C22:6 n‐3, DHA) and vitamin E (VE) on the oxidative stress and liver triglycerides (TG) accumulation induced by high‐fat diet (HFD) in mice. C57BL/6J mice are fed either a control diet or an HFD for 8 weeks. Animals are supplemented with DHA, VE, or DHA + VE, respectively. Supplementation with DHA alone shows significant improvement in oxidative stress and hepatic steatosis in mice. Supplementation with DHA significantly reduces the liver TG and total cholesterol contents, and the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, compared with the HFD. Supplementation with DHA also significantly decreases the mRNA expression level of sterol regulatory element‐binding protein 1C. However, supplementation with VE alone does not show improvement in oxidative stress and hepatic steatosis. DHA + VE supply obtains a superior effect in alleviation of hepatic steatosis than DHA supplementation alone in mice fed by HFD. The efficacy of DHA potentiated by VE can be due to that VE enhances the effect of DHA in decrease of ALT and AST levels and increase of antioxidant enzyme activity and glutathione level in mice fed by HFD.Practical Applications: Supplementation with DHA significantly improves the oxidative stress and hepatic steatosis induced by HFD in mice. The efficacy of DHA in the alleviation of hepatic steatosis induced by HFD is potentiated by VE. These findings may provide a rational basis for the use of DHA and VE co‐supplementation in patients with liver steatosis.