bluuebunny/crossref_metadata_2025_split huggingface dataset:
In silico study on RNA structures of intronic mutations of beta-globin gene
Authors: Sumantri Nur Imaniati , Lischer Kenny , Wijayanti Dian Rachma , Abuzairi Tomy 
Published: July 2020

Background: Mutation of the beta-globin gene (HBB) interferes with primary mRNA transcription, leading to beta-thalassemia disease. The IVS1nt1 and IVS1nt5 mutations were reported as two of the most prevalent intronic mutations associated with beta-thalassemia major. These mutations may affect the mRNA structure of the human beta-globin (HBB) gene. However, the mechanism by which variation in HBB alters the mRNA structure remains unclear. The objective of this study was to unveil the secondary and tertiary conformation difference of the mutants compared to the wildtype using in silico analysis. Methods: The sequence of HBB was obtained from Ensemble database and mutated manually at nucleotides 143 (IVS1nt1G>T) and 147 (IVS1nt5G>C). The RNA secondary and tertiary structure were performed by ViennaRNA Web Services and RNA Composer, respectively. Results and Discussion: The results revealed the unique folding characteristics of each mutations for the secondary and tertiary structures. Based on the structure, unwanted folding occurred in the IVS1nt1G>T and IVS1nt5G>C mRNA structures compared to the wild-type structure. This finding was supported by the results of centroid-based analysis and RNA structure analysis, indicating that the larger loops in IVS1nt1 and IVS1nt5 result in an unstable structure. Our study found that intronic mutations affect the mRNA structure of HBB by altering its folding mechanism.
O trânsito urbano e os fatores estressantes percebidos por motoristas de ônibus: estudo fenomenológico
Authors: Alcantara Vanessa Carine Gil de , Silva Rose Mary Rosa Costa Andrade , Pereira Eliane Ramos , Silva Dejanilton Melo da , Flores Isadora Pinto 
Published: July 2020

Objetivo: discutir as vivências dos motoristas de ônibus através de suas percepções acerca do trânsito e os impactos à saúde sofridos por eles. Método: estudo qualitativo fenomenológico realizado em uma garagem de ônibus situada no Rio de Janeiro. As entrevistas fenomenológicas foram realizadas com 24 motoristas que responderam perguntas semiestruturadas e foram gravadas em dispositivo mp3, posteriormente, transcritas para obtenção das unidades de significado, a coleta de dados ocorreu entre 2017 e 2018. O projeto foi aprovado por Comitê de Ética e Pesquisa. Resultados: da análise fenomenológica das unidades de significados dos depoimentos emergiram duas categorias: o trânsito é instável e estressante e a falta de educação das pessoas afeta os aspectos psíquicos. O ambiente de trabalho determina, expressivamente, o bem-estar dos trabalhadores que nele atuam. Conclusão: diante de tantos limites impostos pela sociedade contemporânea e pelo sofrimento no trabalho, necessário é motiva-los, e também dar-lhes condições de realizar seu trabalho de forma plena.
Femtosecond Bragg grating inscription in an Yb-doped large-mode-area multicore fiber for high-power laser applications
Authors: Alon Yair , Halstuch Aviran , Sidharthan Raghuraman , Yoo Seongwoo , Ishaaya Amiel A. 
Published: July 2020

We demonstrate a direct inscription of a fiber Bragg grating (FBG) in the active cores of an Yb-doped large mode area multicore fiber (MCF). An ultrashort pulsed laser is used to inscribe the FBG simultaneously in all six cores. In order to validate the FBG reflection and uniformity, the FBG is incorporated as a rear mirror in a fiber laser oscillator setup. The MCF, which has been fabricated in-house, has six cores located in a hexagonal-ring shape, each with a 19 µm diameter and an NA of

∼

0.067

. A reflection of

∼

96

%

was measured at a center Bragg wavelength of

∼

1062

n
m

for the inscribed FBG. The laser performance of the MCF with the femtosecond inscribed FBG at its end shows a similar performance to lasing with a free-space commercial volume Bragg grating as the rear-reflector. A slope efficiency of

∼

72.4

%

and a maximum (pump limited) output power of 51.8 W have been obtained for the FBG setup. An effective

M

2

of 3.88, indicating a somewhat multimode operation and a narrow bandwidth of

∼

0.19

n
m

, has been measured for this fiber laser.
High energy mid-infrared laser pulse output from a BaGa4Se7 crystal-based optical parametric oscillator
Authors: Zhang Yongchang , Zuo Yue , Li Zhuang , Wu Bo , Yao Jiyong , Shen Yonghang 
Published: July 2020

We report a high energy, narrow spectral linewidth mid-infrared laser pulse output from a

N
d

:

Y

3

A

l

5

O

12

laser-pumped

B
a
G

a

4

S

e

7

(BGSe) crystal-based optical parametric oscillator (OPO). Output pulse energy of 21.5 mJ was obtained at 3816 nm, with spectral width of 12 nm and pulse width of 11.4 ns, corresponding to peak power as high as 1.89 MW. A BGSe crystal with aperture size of

10

m
m

×

10

m
m

and length of 16 mm was applied as the nonlinear crystal in a pump fed back OPO for achieving such high pulse energy output from the simple oscillator scheme.
Elevated circulating Gpnmb levels are associated with hyperthyroidism
Authors: Lin Jiayang , Zhang Peizhen , Huang Yan , Wei Xueyun , Guo Dan , Liu Jianfang , Liu Deying , Deng Yajuan , Xu Bingyan , Huang Chensihan , Yang Xiaoyu , Lu Yan , Jia Lijing , Zhang Huijie 
Published: July 2020

Background:
Glycoprotein non-metastatic protein B (Gpnmb) has been identified as a new cytokine secreted by hepatocyte that plays an important role in balancing lipid homeostasis and development of obesity and metabolic disorders. However, information is not available regarding the association between circulating Gpnmb and hyperthyroid in humans.

Methods:
We measured serum Gpnmb in 180 hyperthyroid patients and 82 healthy subjects that were recruited from the clinic. Of them, 46 hyperthyroid patients received thionamide treatment for 3 months.

Results:
Hyperthyroid subjects had higher levels of circulating Gpnmb than healthy controls (47.8 ± 10.1 ng/mL vs 31.0 ± 4.9 ng/mL, P < 0.001). Subjects with higher levels of serum free triiodothyronine (T3) and free thyroxine (T4) had higher levels of circulating Gpnmb. After thionamide treatment, levels of circulating Gpnmb in hyperthyroid subjects remarkably declined with significant improvement of thyroid function (P < 0.001). Furthermore, the change of circulating Gpnmb levels was significantly associated with basal metabolic rate (BMR) and thyroid hormones, including free T3 and free T4, adjusting for age, gender, smoking and BMI before thionamide treatment. In multivariable logistic regression analyses, circulating Gpnmb was significantly associated with risks of hyperthyroidism (OR (95% CI): 1.44 (1.20–1.74), P < 0.001), adjusted for age, gender, BMI, fasting glucose, HOMA-IR, LDL-cholesterol, ALT and AST.

Conclusions:
These findings indicate that circulating Gpnmb concentrations are independently associated with hyperthyroid, suggesting that circulating Gpnmb may be a predictor of risk for hyperthyroidism and can be used for therapeutic monitoring.
Quantitative Easing in der Eurozone
Authors: Dierks Leef H. , Hase Leif 
Published: July 2020

Mit nur 1,3 % blieb die EA-19 HVPI-Inflation 2019 weit hinter dem 2,0 % Ziel der EZB zurück. Bisher ergriffene, unkonventionelle geldpolitische Maßnahmen wie das €2.600 Mrd. umfassende APP zeigten nicht den gewünschten Erfolg. Dieser Beitrag untersucht, inwiefern sich die EZB zwecks Stimulierung von Inflation und BIP-Wachstum an den Aktienkäufen der BoJ orientieren sollte. Erste Ergebnisse zeigen, dass diese Maßnahme lediglich zu einem Anstieg der sog. Asset Price Inflation führt, welche letztlich die Finanzstabilität und die Normalisierung der Geldpolitik gefährdete.
Performancemaße von Business Analytics Methoden
Authors: Matthies Benjamin 
Published: July 2020

Controller sollten sich mit den Aussagen und Limitationen der dargestellten Performancemaße grundlegend auseinandersetzen. Accuracy ist ein einfaches Maß für die Richtigkeit eines Modells, welches jedoch nur bei Datensätzen mit ausbalancierten Klassen aussagekräftig ist. Precision und Recall sind zwei komplementäre Kennzahlen zur erweiterten Modellbewertung, zwischen denen jedoch ein Spannungsfeld besteht. Wenn die Vollständigkeit (Recall) der positiven Klassifikation verbessert werden soll, werden in der Regel auch zunehmend ungenaue Ergebnisse erzeugt, was in Konsequenz das Maß Precision reduziert. Ferner ist bei der Interpretation des F1-Scores zu beachten, dass Precision und Recall bei der Berechnung gleich gewichtet werden. Ergänzend zu den vorgestellten Kennzahlen gibt es eine Reihe weiterer Verfahren der Performancebewertung, wie z. B. die ROC (Receiver Operating Characteristic)-Kurve. Für eine erweiterte Darstellung der dargestellten sowie weiterer Kennzahlen siehe Seiter (2019, S. 148 f.).
A separação das famílias na Shoah: vínculos na memória e na identidade judaica
Authors: Levy Sofia Débora 
Published: July 2020

A desumanização dos judeus imposta pela política de Estado nazifascista enfocou, em seus marcos, o desmembramento familiar. Com esta medida, advinda de um olhar coisificado sobre os judeus, a fragilidade de suas defesas individuais e coletivas foi atingida em cheio. Esse esfacelamento é aqui ilustrado nos relatos de sobreviventes que viveram as dolorosas separações impostas às famílias judias durante o Holocausto, em condições dilemáticas e traumatizantes. O vazio dessas perdas familiares é parte significativa da identidade e da memória coletiva do povo judeu na contemporaneidade, que busca aludir aos que pereceram dando-lhes um lugar em suas memórias e na retransmissão da história da Shoah.
Uma Breve Análise Bibliométrica Sobre Biblioteca no Meio Digital
Authors: Batista Rocha Ananda Mayara , Da Silva Dias Fátima Aparecida 
Published: July 2020

O objetivo deste artigo é apresentar a análise sobre o tratamento que a comunidade científica da Ciência da Informação dá ao tema Bibliotecas no ambiente digital. Para isso se utilizou das leis bibliométricas para as análises métricas: Lei de Bradford, Lei de Lotka, Lei de Zipf. Trata-se de uma pesquisa descritiva, teórico-conceitual, com lógica dedutiva, quanto aos procedimentos metodológicos foram utilizados dados primários coletados durante as pesquisas e a abordagem do problema é quali-quantitativa. A análise resultou em um conjunto de dados que foram organizados por meio de técnicas de bibliometria dispostos em quadros e gráficos. Constatou-se que a Revista Ciência da Informação foi a que teve a maior frequência de publicação e que a maioria dos artigos possui autoria múltipla, sendo que os autores preferem usar a expressão “biblioteca digital” apenas no título e no resumo.

Palavras-chave: Bibliometria. Biblioteca Virtual. Biblioteca Eletrônica. Biblioteca Digital. Biblioteca Online.

Abstract
The purpose of this article is to analyze the treatment given by the scientific community of Information Science to the theme libraries in the digital environment Thus, bibliometric laws were used for the metric analysis: Bradford's Law, Lotka's Law, Zipf's Law. This is a descriptive, theoretical-conceptual research, with deductive logic, as the methodological procedures used primary data collected during the research and the problem approach is qualitative and quantitative. Data analysis resulted in a set of data that was organized using bibliometric techniques and arranged in charts and graphs. It was found that the journal Ciência da Informação was the one with the highest frequency of publication and that most articles have multiple authorship and the authors prefer to use the expression “digital library” only in the title and abstract.

Keywords: Bibliometrics. Virtual Library. Electronic Library. Digital Library. Online Library
Clinical profile of leptospirosis and role of various diagnostic methods, a hospital based prospective observational study
Authors: Prakash K 
Published: July 2020

Leptospirosis is a potentially life-threatening zoonotic disease of worldwide distribution. Accurate diagnosis and prompt treatment are essential to minimize morbidity and mortality. The current study was conducted to analyse the clinical profile of leptospirosis and the diagnostic yield of various diagnostic methods.The present study was a cross-sectional study. A total of 60 patients who were suspected of leptospirosis were enrolled in the study. Direct examination of blood was done using dark-ground microscopy, the culture was done by inoculation of the blood sample into the EMJH medium, antibodies against Leptospira was demonstrated using Panbio IgM ELISA kit, and antigen products were demonstrated using polymerase reaction (PCR) with primers G1and G2.The study population included 63% of males and 37% females. A majority of 38% of the study subjects were farmers. Pallor and icterus are the predominant clinical signs found among 96% of the study population. IgM ELISA has labelled the highest number i.e. 55 (91.66%) of subjects as positive. The number of subjects diagnosed positive by PCR, culture and Dark ground microscopy (DGM) were 33 (55.00%), 22 (36.66%) and 12 (20%) subjects respectively.Leptospirosis proves to be an important health concern. Prominent clinical conditions were observed. IgM-ELISA proved superior to Dark ground microscopy (DGM), Culture and Polymerase chain reaction (PCR) and suitable for early diagnosis of leptospirosis.
IMPLEMENTAÇÃO DE NÚCLEO DE SEGURANÇA DO PACIENTE EM UNIDADE DE PRONTO ATENDIMENTO: PERSPECTIVAS DOS ENFERMEIROS
Authors: Silva Cunha Simone Graziele , Santos Clemente Gabriela , Simões Almeida Larissa Franciele , Guerra Siman Andréia , Menezes Brito Maria José 
Published: July 2020

<p>Objetivo: compreender a implementação do Núcleo de Segurança do Paciente em uma Unidade de Pronto Atendimento na perspectiva dos enfermeiros. Método: estudo de caso qualitativo, realizado em uma Unidade de Pronto Atendimento em um município da Região Centro-Oeste de Minas Gerais, Brasil, com a participação de 12 enfermeiros. Os dados foram coletados de setembro a novembro de 2019, por meio de entrevista guiada por roteiro semiestruturado, Técnica do Gibi e observação. Para a análise adotou-se a análise de conteúdo. Resultados: emergiram duas categorias temáticas: Desafios da implementação do Núcleo de Segurança do Paciente e Facilidades da implementação do Núcleo de Segurança do Paciente. Conclusão: foram identificados fragilidades e desafios que impactam no processo de implementação do núcleo e consequentemente no cuidado ao paciente, o que pode servir para subsidiar a implantação de novos Núcleos de Segurança do Paciente em serviços de saúde.</p><p>Descritores: Serviços Médicos de Emergência. Enfermagem. Segurança do Paciente.</p>
Evaluation of Implementation of Maslows Hierarchy of Needs to Fulfil the Needs of Freelance Journalist and Adaptation of Psychological Contract into Employment Relationship in Hong Kong
Authors: Hing Po Lam Dr Vincent 
Published: July 2020

The large news newspaper and media corporation previously provides long-term and stable career for journalist to move up on the career path from junior reporter to become editor in chief. Maslow's hierarchy of needs has been used as the motivation paradigm to fulfil every stage of needs from physiological needs to the highest form of self-actualization needs.However, when the change of media market employment relationship and social media as the main focus of news content, more large media corporation uses contracted freelance journalist with expertise in their particular field as as finance, politics, sports, horse racing, travel, dine and wine as content contributor. The relationship between news corporation and journalist has changed from employment to partnership. Therefore, it remains in doubt whether Maslow's hierarchy of needs still hold for staff management in today media industry.
In addition, freelance journalist is himself a KOL and expert in their field and their follower helps the media platform increase the readership and click rate which translates into increasing their advertising revenue. As such, there is psychological contract which consists of intrinsic (Pay) and extrinsic values (other factors) and different expectation from both party on this employment contract in this new form of partnership.
The aim of this paper is to examine from freelance journalists point of view whether Maslow's hierarchy of needs applies on them and what are the extrinsic values which hold them on this employment relationship with media corporation.
Meningkatkan Kecintaan Anak pada Al Qur’an Melalui “Kebun Qur’an” (Studi Kasus Di Pondok Pesantren Enterpreneur Al Mawaddah Kudus)
Authors: Rochanah Rochanah 
Published: July 2020

<p align="center"><strong>Abstrak </strong></p><p>Penelitian ini merupakan penelitian lapangan dengan pendekatan kualitatatif. Teknik pengumpulan data melalui observasi, wawancara dan dokumentasi. Secara eksplisit, permasalahan yang peneliti angkat dalam penelitian ini adalah; bagaimana upaya meningkatkan kecintaan anak pada al Qur’an melalui eduwisata kebun qur’an yang terdapat di pondok pesantren <em>enterpreneur</em> Mawaddah Kudus. Lokus penelitian ini adalah pondok pesantren enterpreneur al Mawaddah Kudus. Penelitian ini adalah penelitian kualitatif dengan metode deskriptif-analitis. Teknik pengumpulan data melalui observasi, wawancara dan dokumentasi.<strong> </strong>Hasil penelitian menunjukkan bahwa upaya meningkatkan kecintaan anak pada al Qur’an melalui eduwisata kebun qur’an Mawaddah yakni dengan menyajikan berbagai buah dan tumbuhan yang disebutkan di Al Qur’an. Selain itu, anak diajak untuk membaca surat dalam al Qur’an yang menyebutkan buah, misalnya buah tin dalam surat at tin. Anak juga dijelaskan tentang manfaat yang terdapat pada masing-masing buah. Dengan cara tersebut, diharapkan akan semakin menambah kecintaan anak pada al Qur’an.</p><p><strong> </strong></p>
Analisis Matematis Pengurangan pada Bilangan Bulat dengan Penggunaan Dekak-Dekak di MI Nurul Huda
Authors: Nurdyansyah Nurdyansyah 
Published: July 2020

<p>Penelitian ini bertujuan untuk mendiskripsikan (1) cara meningkatkan pemahaman konsep pengurangan bilangan bulat melalui penggunaan dekak-dekak peserta didik kelas V MI Nurul Huda, (2) penggunaan dekak-dekak dapat membantu meningkatkan pemahaman konsep pengurangan bilangan.</p><p>Penelitian ini menggunakan rancangan PTK. Subyek penelitian ini adalah peserta didik kelas V sebanyak 23 peserta didik. Instrumen yang digunakan untuk mengumpulkan data adalah lembar observasi ,tes, dan wawancara. Teknik analisis data yang dipakai adalah t-tes.</p><p>Hasil penelitian ini menunjukkan bahwa pengurangan pada bilangan bulat dengan penggunaan dekak-dekak dilakukan dengan tahap (1) pemahaman konsep, (2) penentuan konsep , dan (3) pemantapan materi. Pada tahap pemahaman konsep peserta didik secara kelompok dibimbing oleh pendidik menggunakan media dekak-dekak, (a) peserta didik membagi manik-manik berwarna merah dan hitam, (b) melakukan pengerjaan pengurangan bilangan bulat dengan memindaahkan manik-manik merah atau hitam pada tempatnya untuk mencari hasil pengurangan bilangan bulat. Penggunaan dekak-dekak dapat membantu meningkatkan pemahaman konsep bilangan bulat peserta didik kelas V MI Nurul Huda dapat dilihat dari nilai t-tes yang menyatakan ada peningkatan pemahaman sebesar 32% dari sebelumnya. Adapun rata-rata nilai tes peserta didik pada siklus I (65,9) dan mengalami peningkatan pada siklus II (83,3).</p><p>Berdasarkan hasil penelitian, disarankan: (1) kepada pendidik dalam kegiatan pembelajaran matematika hendaknya dapat menggunakan media dekak-dekak pada konsep bilangan bulat,(2) kepada pendidik matematika agar dapat melakukan penelitian tindakan yang sama atau mengembangkan penelitian ini pada kelas-kelas yang lain di MI Nurul Huda secara berkesinambungan. </p><p><strong> </strong></p>
The development and validation of a Questionnaire in Bahasa Malaysia to assess problems of vision or feelings about vision among patients with cataracts.
Authors: Thevi Thanigasalam , Abas Adinegara Lutfi , Chang Stephanie Yen Li 
Published: July 2020

Abstract
Purpose

We conducted the study to compare the validation properties of the English version of the Questionnaire and the Bahasa Malaysia (Malay Language) version regarding the Quality of Life of patients with cataracts.

Methods

We carried out a cross-sectional study collecting data between June 2017 and March 2018 in the pre-operative Eye Clinic of Hospital Melaka.

The Malay version was translated by two independent translators who were well versed in both languages.

Methods used to validate the standard questionnaire included the use of construct validity via factor analysis and the deployment of reliability test through assessment of internal consistency via Cronbach’s alpha.

Results

We observed both English and Bahasa Malaysia versions to have high reliability with Cronbach’s alpha values of 0.90 and above in factors on difficulty with activities and responses to vision problems.

Exploratory factor analysis performed revealed that the three-factor model fits the data well for the English version of the questionnaire - difficulty with activities (23.81% of variance), responses to vision problem (22.22% of variance) and general health and vision (14.68% of variance).

The Bahasa Malaysia version of the questionnaire produced three factors with two of the factors resembling the factors from the original version of the questionnaire - difficulty with activities (24.28% of variance) and responses to vision problem (23.66% of variance).

Conclusion

The present study observed that both the English and Bahasa Malaysia versions of the NEI VFQ-25 have comparable construct validity to the original American version. With high validity and reliability, the tool shall be able to provide health care providers the assessment of impact due to cataract and other ophthalmic conditions on the vision-related quality of life of ophthalmic patients.
Short- and Long-Term Follow-Up of Patients with Benign Esophageal Perforation
Authors: Brinkmann Sebastian , Knepper Laura , Fuchs Hans Friedrich , Hoelscher Arnulf Heinrich , Kuhr Kathrin , Santos Daniel Pinto dos , Bartella Isabel , Plum Patrick , Chon Seung-Hun , Herbold Till , Bruns Christiane Josphine , Schroeder Wolfgang , Leers Jessica Marzelline 
Published: July 2020

Abstract
Background

Esophageal perforation is associated with high morbidity and mortality. In addition to surgical treatment, endoscopic endoluminal stent placement and endoscopic vacuum therapy (EVT) are established methods in the management of this emergency condition. As health-related quality of life (HRQoL) is becoming a major issue in the evaluation of any therapeutic intervention not much is known about HRQoL, particular in the long-term follow-up of patients treated for benign esophageal perforation with different treatment strategies.
Methods

Patients treated for benign esophageal perforation at the University Hospital Cologne from January 2003 to December 2014 were included. Primary outcome and management of esophageal perforation were documented and long-term quality of life was assessed using the Gastrointestinal Quality of Life Index (GIQLI), the Health-Related Quality of Life Index (HRQL) for patients with gastroesophageal reflux disease (GERD) and the European Organization for Research and Treatment of Cancer (EORTC) questionnaires for general and esophageal cancer specific QoL (QLQ-C30 and QLQ-OES18). .
Results

58 patients were included in the study. Based on primary treatment patients were divided into an endoscopic (n = 27; 46.6%), surgical (n = 20; 34.5%) and conservative group (n = 11; 19%). Short- and long-term outcome, as well as quality of life were compared. HRQoL was measured after a median follow-up of 49 months HRQoL was generally reduced in patients with benign esophageal perforation. Endoscopically treated patients showed the highest GIQLI overall score and highest EORTC general health status, followed by the conservative and the surgical group.
Conclusion

HRQoL in patients with benign esophageal perforation is reduced even in the long-term follow-up. Temporary stent or EVT is effective and provides a good alternative to surgery not only in the short-term but also in the long-term follow-up.