bluuebunny/crossref_metadata_2025_split huggingface dataset:
LINC‐PINT alleviates lung cancer progression via sponging miR‐543 and inducing PTEN
Authors: Wang Shu , Jiang Wenyang , Zhang Xinghua , Lu Zilong , Geng Qing , Wang Wei , Li Nan , Cai Xinyong 
Published: January 2020

AbstractLong intergenic nonprotein coding RNA p53‐induced transcript (LINC‐PINT) has been reported to participate in various cancers. Here, we investigated the effects of LINC‐PINT on lung cancer progression. Firstly, in our study, we implied that LINC‐PINT was obviously decreased in NSCLC. Thereafter, in A549 and H1299 cells, LINC‐PINT was upregulated via transfecting LV‐LINC‐PINT. As exhibited, LINC‐PINT repressed cell proliferation and cell colony formation of A549 and H1299 cells. Subsequently, flow cytometry evidenced that A549 and H1299 cell apoptosis was obviously triggered and the cell cycle was arrested in G1 phase. Then, migration and transwell invasion experiments were carried out to detect the cell migration and invasion capacity. We found A549 and H1299 cell migration and invasion capacity were restrained by the upregulation of LINC‐PINT. Meanwhile, we predicted that miR‐543 could function as the target of LINC‐PINT and the association was verified. Moreover, we exhibited that miR‐543 was remarkably increased in lung cancer, which could be regulated by LINC‐PINT negatively. Furthermore, PTEN could act as the downstream target of miR‐543 and upregulation of miR‐543 repressed PTEN, which was reversed by LV‐PINT in A549 and H1299 cells. Finally, xenografts were utilized to confirm the function of LINC‐PINT on lung cancer. All these findings concluded that LINC‐PINT exerted crucial biological roles in NSCLC through sponging miR‐543 and inducing PTEN.
Synthesis of Catechin‐Rare Earth Complex with Efficient and Broad‐Spectrum Anti‐Biofilm Activity
Authors: Liu Lu , Xiao Xiao , Li Ke , Li Xia , Shi Bi , Liao Xuepin 
Published: January 2020

AbstractBiofilm is the crucial reason of clinical infections. Herein, green tea based polyphenol (catechin) and rare earth (RE) metal ions were employed for the preparation of catechin–RE complexes with significant anti‐biofilm properties. The complexes were characterized by FT‐IR, Raman spectroscopy, X‐ray photoelectron spectroscopy (XPS) and dynamic light scattering (DLS), which suggested that catechin coordinated with RE3+ through its ortho phenolic hydroxy groups. The prepared catechin‐RE showed significant effects in anti‐biofilm growth against P. aeruginosa (Gram‐negative bacteria), S. sciuri (Gram‐positive bacteria), and A. niger (fungi), which significantly exceeded the utilization of catechin or RE3+. Morphological observations indicated that catechin supplied cell affinity to transfer RE3+ and helped to damage cell membrane, which act as a carrier to exert cytotoxicity of RE3+ to realize anti‐biofilm. Differential gene expression analysis described gene expression changes induced by catechin‐RE, including 56, 272 and 2160 downregulated genes for P. aeruginosa, S. sciuri and A. niger, respectively, which suggested critical changes in cellular metabolism, growth and other processes. These results illustrate the outstanding superiority of catechin‐RE complexes in anti‐infection aspect, i. e., the green tea based rare earth complexes are promising candidates for anti‐biofilm applications to address serious challenges in the prevention of multiple infections.
Severe muscle pain and stiffness due to dexmethylphenidate
Authors: Kon Jacob J. , Kon Alexander A. 
Published: January 2020

AbstractDexmethylphenidate, and potentially other methylphenidates used in the treatment of attention deficit hyperactivity disorder (ADHD), may cause severe muscle pain and stiffness. Medication side effects should be considered as the possible cause if a patient with ADHD develops severe symptoms.
Multilayered Two‐Dimensional V2CTx MXene for Methane Dehydroaromatization
Authors: Thakur Raj , Hoffman Megan , VahidMohammadi Armin , Smith Justin , Chi Mingyang , Tatarchuk Bruce , Beidaghi Majid , Carrero Carlos A. 
Published: January 2020

AbstractWe report a thermally stable multilayered two‐dimensional vanadium carbide (V2CTx) MXenes catalyst for the direct conversion of methane (CH4) into benzene (C6H6). The multilayered carbide structure shows state‐of‐the‐art CH4 conversion 11.8 % with a C6H6 formation rate of 1.9 mmol gcat−1h−1 (4.84 % C6H6 yield) at 700 °C, which is comparable to the benchmark Mo/ZSM‐5 catalyst. The structure‐activity relationship was explored by numerous characterization techniques including in‐situ/operando Raman‐MS, ex‐situ X‐ray diffraction (XRD), scanning electron microscopy (SEM), X‐ray photoelectron spectroscopy (XPS), and ammonia temperature programmed desorption (NH3‐TPD). This work provides a new platform to design and explore multilayered two‐dimensional catalysts demonstrating confinement effect to convert CH4 into *C2H3 intermediates which further oligomerize inside multilayered structures producing C6H6 as the final product.
Manipulating the Geometric and Electronic Structures of Manganese Nitrides for Ammonia Synthesis
Authors: Shan Nannan , Huang Chaoran , Lee Robert T. , Manavi Narges , Xu Lianbin , Chikan Viktor , Pfromm Peter Heinz , Liu Bin 
Published: January 2020

AbstractManganese (Mn) nitrides are important nitrogen (N) carriers for small‐scale intermittent ammonia (NH3) synthesis. However, only 3∼8 % of lattice N are converted into NH3. In this study, the geometric and electronic structures of well‐defined Mn4N and Mn2N lattices were altered using transition metal heteroatoms (Cr, Fe, Co, Ni, Mo) to understand the driving force behind lattice N diffusion and extraction. Density Functional Theory (DFT) revealed that the binding of early hydrogenation product (NH) follows a linear relationship with lattice N over a wide range of close‐packed surfaces. But, the binding of NH2 and NH3 are more sensitive to the geometric and electronic structures. Further, the chemical bonding can be quantitatively characterized with the covalency derived from Crystal Orbital Hamiltonian Population (COHP). In the Eley Rideal‐Mars van Krevelan pathway, the overall NH3 formation free energy (
) and lattice N diffusion barrier (
) are the respective thermodynamic and kinetic determining factors. Aided by a rate‐determining step (RDS) model, Mn4N modified with Fe, Co, Ni single‐atom dopants all show enhanced rates for NH3 formation.
Quantifying Capacitive‐Like and Battery‐Like Charge Storage Contributions Using Single‐Nanoparticle Electro‐optical Imaging
Authors: Evans R. Colby , Nilsson Zach , Balch Brenden , Wang Li , Neilson James R. , Weinberger Christopher R. , Sambur Justin B. 
Published: January 2020

AbstractPseudocapacitors promise to combine the high‐rate capability of electrochemical capacitors with the high energy‐density of batteries. A major challenge in the field is to demonstrate that pseudocapacitors behave electrochemically like a capacitor and the charge storage process is faradaic in nature. It is challenging to do so because pseudocapacitive charging has the same electrical signatures as non‐faradaic electrical double‐layer charging. Here we use electro‐optical imaging to measure Li‐ion insertion reactions in single WO3 nanoparticles. On average, these WO3 particles exhibit a hybrid charge storage mechanism: both diffusion‐limited (battery‐like) and pseudocapacitive (capacitor‐like) mechanisms contribute to the total charge stored. Individual particles exhibit different charge storage mechanisms at the same applied potential. Longer nanorods store more pseudocapacitive charge than shorter nanorods, presumably due to 1) a surface step edge gradient that exposes large hexagonal window Li‐ion binding sites along the nanorod length and/or 2) higher structural water content that influences the Li‐ion binding energetics and diffusion behavior. Importantly, we quantified the penetration depth of Li‐ion insertion and concluded that Li ions insert as deep as two‐unit cells below the surface. The methodology presented herein can be applied to a wide range of solid‐state ion‐insertion materials.
A Two‐Step Modified Sequential Deposition Method‐based Pb‐Free (CH3NH3)3Sb2I9 Perovskite with Improved Open Circuit Voltage and Performance
Authors: Ahmad Khursheed , Kumar Praveen , Mobin Shaikh M. 
Published: January 2020

AbstractIn the last decade, photovoltaic devices employing lead halide perovskites as light absorber have pulled the attention of researchers due to their outstanding performance. However, the lead halide perovskite based photovoltaic devices suffering from the toxicity of lead (Pb) and lower stability in air. Herein, we have replaced Pb with less toxic antimony (Sb) to prepare air stable and Pb‐free perovskite light absorber. Moreover, we have developed a two‐step procedure to prepare the high quality films of perovskite light absorber with device architecture of FTO/CL‐TiO2/m‐TiO2/MASbI/HTM/Au. This fabricated Pb‐free perovskite solar cell device prepared with two‐step procedure shows good performance with remarkably good open circuit voltage of 740 mV.
FeIII–Salen‐Based Probes for the Selective and Sensitive Detection of E450 in Foodstuff
Authors: Yadav Prerna , Jakubaszek Marta , Spingler Bernhard , Goud Bruno , Gasser Gilles , Zelder Felix 
Published: January 2020

AbstractInorganic pyrophosphate (PPi) is considered as a diagnostic marker for various diseases such as cancer and vascular calcification. PPi also plays an important preservative role as an additive E450 in foodstuff. In this work, a selective FeIII–salen‐based probe for PPi is described; this probe disassembles in the presence of the target analyte into its molecular blocks, 1,2‐propanediamine and 3‐chloro‐5‐formyl‐4‐hydroxybenzenesulfonic acid. The latter signaling unit leads to a fluorometric response. Compared with a related prototype, the new complex shows a 2.3‐times stronger emission at 500 nm and a 155‐times better selectivity of PPi over adenosine triphosphate (ATP). Importantly, the new probe was successfully applied for detecting E450 in foodstuff.
How to Bend a Cumulene
Authors: Barquera‐Lozada José Enrique 
Published: January 2020

AbstractAllenes (carbodicarbenes) and [3]cumulenes are linear carbon chains that can be bent when the terminal group has a strong carbene nature. This bending can be quite pronounced in allenes but not in [3]cumulenes. In this study, how N‐heterocyclic or cyclic (alkyl)(amino) carbene (NHC and CAAC, respectively) terminal groups can modify the linear structure of [n]cumulenes has been analyzed. A low π acidity of the terminal carbene affects the linearity of [2n]cumulenes. Indeed, it has been found that the NHC [4]cumulene is extremely bent, contrary to classical [4]cumulenes. The predicted NHC [4]cumulene or tricarbodicarbene has two lone pairs and the π electrons are delocalized over the whole molecule. More significantly, DFT calculations have shown that this bent [4]cumulene is very stable, considerably more so than the corresponding [3]cumulene, which has been elusive to synthesize. Remarkably, calculations have shown that all the NHC [2n]cumulenes are more than 25 kcal mol−1 more stable than the [2n−1]cumulenes.
The impact of signboard‐building color combinations on color harmony and legibility
Authors: Won Seahwa , Lee YounJin , Park YungKyung 
Published: January 2020

AbstractThe aim of this study was to investigate the impact of signboard‐building color combinations on color harmony and legibility. Two hundred and three participants rated 54 signboard‐building color combinations against two scales of color harmony and legibility. In this article, the terms “brick,” “stone,” and “glass” refer to three types of building exteriors used in the experiment (ie, brick masonry, greystone, and curtain walls, respectively). Major findings are as follows: (a) there was a positive linear correlation between color harmony and legibility in all three types of building exteriors, (b) the type of building exterior affected the color harmony and legibility of signboard colors, (c) no hue‐related patterns were observed, (d) the effects of chroma differences on color harmony were weak and the effects of chroma differences on legibility were moderate, (e) the effects of lightness differences on color harmony and legibility were strong in brick, but the effects of lightness differences were weak in stone and glass, (f) white color combinations (ie, color pairs including white signboards) turned out to be the most harmonious and legible, and (g) color combinations of light signboards and dark buildings (negative polarity) were rated most harmonious and legible, with the exception of vivid red (positive polarity). The findings of this study provide insight into the characteristics of harmonious and legible colors in the context of signboard design.
In SituShell‐Isolated Nanoparticle‐Enhanced Raman Spectroscopy of Nickel‐Catalyzed Hydrogenation Reactions
Authors: Wondergem Caterina S. , Kromwijk Josepha J. G. , Slagter Mark , Vrijburg Wilbert L. , Hensen Emiel J. M. , Monai Matteo , Vogt Charlotte , Weckhuysen Bert M. 
Published: January 2020

AbstractSynthesis methods to prepare lower transition metal catalysts and specifically Ni for Shell‐Isolated Nanoparticle‐Enhanced Raman Spectroscopy (SHINERS) are explored. Impregnation, colloidal deposition, and spark ablation have been investigated as suitable synthesis routes to prepare SHINERS‐active Ni/Au@SiO2catalyst/Shell‐Isolated Nanoparticles (SHINs). Ni precursors are confirmed to be notoriously difficult to reduce and the temperatures required are generally harsh enough to destroy SHINs, rendering SHINERS experiments on Ni infeasible using this approach. For colloidally synthesized Ni nanoparticles deposited on Au@SiO2SHINs, stabilizing ligands first need to be removed before application is possible in catalysis. The required procedure results in transformation of the metallic Ni core to a fully oxidized metal nanoparticle, again too challenging to reduce at temperatures still compatible with SHINs. Finally, by use of spark ablation we were able to prepare metallic Ni catalysts directly on Au@SiO2SHINs deposited on a Si wafer. These Ni/Au@SiO2catalyst/SHINs were subsequently successfully probed with several molecules (i. e. CO and acetylene) of interest for heterogeneous catalysis, and we show that they could be used to study thein situhydrogenation of acetylene. We observe the interaction of acetylene with the Ni surface. This study further illustrates the true potential of SHINERS by opening the door to studying industrially relevant reactions underin situoroperandoreaction conditions.
Origin of Hydrocarbons Stability from a Computational Perspective: A Case Study of Ortho‐Xylene Isomers
Authors: Mitoraj Mariusz P. , Sagan Filip , Szczepanik Dariusz W. , de Lange Jurgens H. , Ptaszek Aleksandra L. , van Niekerk Daniel M. E. , Cukrowski Ignacy 
Published: January 2020

AbstractIt is shown herein that intuitive and text‐book steric‐clash based interpretation of the higher energy “in‐in” xylene isomer (as arising solely from the repulsive CH⋅⋅⋅HC contact) with respect to the corresponding global‐minimum “out‐out” configuration (where the clashing C−H bonds are tilted out) is misleading. It is demonstrated that the two hydrogen atoms engaged in the CH⋅⋅⋅HC contact in “in‐in” are involved in attractive interaction so they cannot explain the lower stability of this isomer. We have proven, based on the arsenal of modern bonding descriptors (EDDB, HOMA, NICS, FALDI, ETS‐NOCV, DAFH, FAMSEC, IQA), that in order to understand the relative stability of “in‐in” versus “out‐out” xylenes isomers one must consider the changes in the electronic structure encompassing the entire molecules as arising from the cooperative action of hyperconjugation, aromaticity and unintuitive London dispersion plus charge delocalization based intra‐molecular CH⋅⋅⋅HC interactions.
Photoelectrochemistry for Measuring the Photocatalytic Activity of Soluble Photosensitizers
Authors: Khan Shahid Ullah , Trashin Stanislav A. , Korostei Yuliya S. , Dubinina Tatiana V. , Tomilova Larisa G. , Verbruggen Sammy W. , De Wael Karolien 
Published: January 2020

AbstractWe introduce a rapid method to test the photocatalytic activity of singlet‐oxygen‐producing photosensitizers using a batch cell, a LED laser and a conventional potentiostat. The strategy is based on coupling of photo‐oxidation of hydroquinone and simultaneous electrochemical reduction of its oxidized form at a carbon electrode in an organic solvent (methanol). This scheme gives an immediate response and avoids complications related to long‐term experiments such as oxidative photo‐degradation of photosensitizers and singlet oxygen traps by reactive oxygen species (ROS). Among the tested compounds, a fluoro‐substituted subphthalocyanine showed the highest photocurrent and singlet oxygen quantum yield (ΦΔ) in comparison to phenoxy‐ and tert‐butyl‐substituted analogues, whereas the lowest photocurrents and yields were observed for aggregated and dimeric phthalocyanine complexes. The method is useful for fast screening of the photosensitizing activity and represents the first example of one‐pot coupling of electrochemical and photocatalytic reactions in organic media.
Eutectic Synthesis of High‐Entropy Metal Phosphides for Electrocatalytic Water Splitting
Authors: Zhao Xinhui , Xue Zhimin , Chen Wenjun , Wang Yaqing , Mu Tiancheng 
Published: January 2020

AbstractHigh‐entropy materials, a new class of alloys that incorporate five or more principal elements into single‐phase crystal structures, have received considerable interest in materials science and engineering. Considering the tailored composition and disordered configuration, these high‐entropy materials may arouse functional synergism towards electrocatalysis. Here, a new strategy for preparing high‐entropy metal phosphides (HEMPs) was developed by a eutectic solvent method. The as‐prepared HEMP possessed a single metal phosphide phase with up to five homogenously distributed metal components. The versatile application of high‐entropy materials was highlighted by integrating the HEMP catalyst into a two‐electrode configuration for electrocatalytic water splitting.
Improve uniformity for an indoor visible light communication system
Authors: Gismalla Mohammed S.M. , Abdullah Mohammad F.L. , Niass Mussaab I. , Das Bhagwan , Mabrouk Wafi A. 
Published: January 2020

SummaryVisible light communication (VLC) is an alternative technology to the radio frequency (RF) for different applications in the indoor and outdoor environments, it could be utilized for illumination and communication simultaneously, and it offers several advantages over contemporary RF technologies such as low power consumption, free license, large bandwidth, and being friendly to the environment. In this paper, an indoor VLC system uniformity improvement in terms of high received power, signal‐to‐noise ratio (SNR), and bit rate, with RMS delay spread reduction, is proposed. It features a novel model that utilizes a 13‐optical attocells configuration on the ceiling. Moreover, proposed model was evaluated at different semi‐angle at half power. The average received power and SNR were improved to 2.85 dBm and 75.5 dB, while achieved received power and SNR levels at the center of the room were 4.92 dBm and 79.5 dB, respectively. A minimum average RMS delay spread of 0.4749 nanoseconds is obtained, while the highest average bit rate calculated is 211 Mb/s. The proposed model provides a better communication quality and meets illumination standards requirements.
Cauliflower‐like NiCo2O4−Zn/Al Layered Double Hydroxide Nanocomposite as an Efficient Electrochemical Sensing Platform for Selective Pyridoxine Detection
Authors: Amini Roghayeh , Asadpour‐Zeynali Karim 
Published: January 2020

AbstractIn the present study, a cauliflower‐like NiCo2O4−Zn/Al
layered double hydroxide (NiCo2O4−Zn/Al LDH) nanocomposite was used as a novel electrode material for the sensitive and selective determination of pyridoxine (vitamin B6). The structure and morphology of the as‐prepared nanocomposite were characterized by X‐ray diffraction (XRD), FT‐IR, field emission scanning electron microscopy (FESEM) and energy dispersive X‐ray spectroscopy (EDX). The NiCo2O4−Zn/Al LDH nanocomposite exhibited excellent electrocatalytic ability in the oxidation of pyridoxine, which could result from the synergistic effect of the two components. The developed sensor also provided a selective determination of pyridoxine in the presence of other species such as vitamins (B1, B2, B12 and ascorbic acid), inorganic ions and biomolecules. The fabricated sensor showed a good linear response for pyridoxine over the concentration ranges 2×10−7–2.0×10−4 mol L−1 with a low detection limit of 8.6×10−8 mol L−1. Finally, the proposed method was successfully applied for the determination of pyridoxine in commercial tablets and plasma samples with satisfactory results. Furthermore, this novel sensor displayed superior benefits in terms of stability, sensitivity, repeatability and cost. The present work aims to expand NiCo2O4 based nanocomposites to sensor fields and promote the development of pyridoxine sensors.
Protocol for sand control screen design of production wells for clayey silt hydrate reservoirs: A case study
Authors: Li Yanlong , Ning Fulong , Wu Nengyou , Chen Qiang , Nouri Alireza , Hu Gaowei , Sun Jiaxin , Kuang Zenggui , Meng Qingguo 
Published: January 2020

AbstractThe process of extracting natural gas from gas hydrate‐bearing sediments (GHBS) may yield significant sand influx due to the metastable nature of GHBS. Selecting appropriate sand control media is vital to addressing the challenges caused by excessive sand production. This study proposes a protocol called holding coarse expelling fine particles (HCEFP) for sand control design. The protocol aims to provide a new optimization method for screen mesh size selection for clayey silt hydrate reservoirs. Detailed optimizing procedures of proper candidate screen mesh sizes in hydrate exploitation well in clayey silt hydrate reservoirs are depicted based on the HCEFP. Then, the site W18, which is located in the Shenhu area of the northern South China Sea, is taken as an example to illustrate the optimization procedure for screen mesh size selection. The results reveal that complete solid retention via a standalone screen is rarely beneficial as high clay contents can adversely affect wellbore productivity due to excessive plugging. Screen aperture size selection for clayey silt hydrate wells should strike a balance between retaining coarser particles and avoiding screen blockage by the relatively fine particles. Furthermore, longitudinal heterogeneity of the PSDs also increases the difficulties associated with sand control design. Multistage sand control optimization is necessary in hydrate production wells. For Site W18, we recommend that the entire production interval can be divided into two subintervals for multistage sand control operations.