bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Green” principles of sustainable development of road and transport infrastructure of the cities of Ukraine
Authors: Vnukova N V , Zhelnovach G M , Kozlovskyi O V 
Published: August 2020

Abstract
The paper is devoted to the development of criteria for the implementation of the principles of “green” and sustainable development of road and transport infrastructure of the cities of Ukraine on the basis of world experience, as well as own research. It is established that the world experience offers a number of systems for assessing environmental friendliness and sustainability of the development of transport infrastructure, which cannot be applied unambiguously and without adaptation in the cities of Ukraine. Therefore, environmentally significant criteria for assessing compliance with the requirements of “green” standards for the development of the city’s transport infrastructure in the context of assessing its life cycle stages, which in the future will help the environmentally balanced development of the city’s transport system were developed and proposed in the paper. As an example of the practical application of the criteria for “green” construction and assessment of environmental sustainability for the development of the road network, a mechanism was developed and proposed to assess the environmental efficiency of the development of the urban bicycle transport network based on estimates of reduced fuel consumption, pollutant emissions and noise levels by replacing motor work with cycling.
Problems of Formation of Architectural and Spatial Composition Organization of the Environment of Donbas Mono City
Authors: Honcharova I V , Myronenko V P , Hubanov O V 
Published: August 2020

Abstract
One of the city-forming factors for the development of the Donbas region is the creation of large full-cycle industrial complexes situated together as a group of several related industries. It allowed for the efficient use of urban lands and opened up wide range of opportunities for achievement of technological, compositional and spatial unity of industrial complexes. During industrial cities development, the residential districts was formed as large industrial complexes expanded. The historic centers of industrial cities are characterized by the grouping of cultural heritage sites around individual (usually the most powerful) industrial enterprises, most often coal mines, metallurgical and coke-chemical enterprises. The most advanced city planning ideas of the 20-50’s were fully reflected in the planning structure and features of construction of industrial cities of Donbas. Many preserved and partially lost monuments of industrial architecture, as well as those that can claim such a status, are objects of protection of historical and cultural heritage, characteristic of the industrial type of cities. There are a number of specific problems inherent to cities of different categories. The major ones are those caused by significant discrepancy between the real state of the urban environment and its required state. Finding solutions to problems of corporate cities requires a multifaceted approach, as the prerequisites and characteristics of different cities can vary greatly due to historical and economic factors. Therefore, approaches to addressing the issue of corporate cities should be considered individually, considering global trends and regional peculiarities of individual regions.
Principles of architectural and planning arrangements for school complexes on difficult terrain
Authors: Sleptsov O , Karban A 
Published: August 2020

Abstract
The article deals with issue of educational infrastructure in Ukraine. The authors analyzed recent research and publications with respect to development, design and construction of educational institutions. The article provides the rationale for the necessity to have school complexes on difficult terrain in Ukraine at this stage, given the needs of education, architecture and urban planning. The article provides the definition of school complexes on difficult terrain. It identifies specificities of building on difficult terrain and points out the advantages and disadvantages of shaping architectural setting of educational institutions given these conditions. The article lists and characterizes principles of shaping architectural and planning arrangements of these complexes. The distinction is made between individual principles directly linked to the object of research, school complexes on difficult terrain, and general ones applicable for all types of buildings. The study distinguishes artistic and composition principles that have an impact on forming school complexes on difficult terrain. The article also identifies approaches, means and techniques to apply identified principles.
The Modern Trends of an Architectural Parterre Formation
Authors: Dubinskiy V P , Skorobohatko O V 
Published: August 2020

Abstract
Theoretical prerequisites for the appearance of term of “architectural parterre” with the aim of its further use have been considered in the article. The historical prerequisites for an architectural parterre formation in the urban environment are given and the main types of spatial elements of a city structure are enumerated. The peculiar features of human perception of the urban environment in an architectural parterre zone are described. The analysis of the conditions of a dwelling unit density, allowing an architectural parterre formation, has been conducted and the acceptable physical dimensions of an architectural parterre have been derived. A list of urban design elements of an architectural parterre structure has been revealed. Three aspects of increasing the quality of an architectural parterre, namely: ergonomics, ecology and esthetics have been derived on the basis of modern features in open spaces organization in the urban environment. Subsequently, modern trends of an architectural parterre formation have been revealed, namely: the engagement of the public into the formation of design tasks in the process of creating an architectural parterre spatial elements; removal of the carriageway from the streets or “de-mulling”; transforming spatial elements into “places” distinguished by their unique design solutions and architectural metaphor; creating a “hybrid zone” in front of a dwelling unit; providing multiple tasks of an architectural parterre spatial elements or “mixed use”; including of an architectural parterre spatial elements into the system of green corridors of an urban environment.
Problems of environmental safety of water disposal as a factor of sustainable urban development
Authors: Iurchenko V.O. , Lebedeva E.S. , Levashova Yu.S. , Kovalenko A. V. 
Published: August 2020

Abstract
This paper examines the environmental safety of water disposal systems – one of the life support systems for a population – as a condition for sustainable urban development. Gaseous emissions from such systems contain a number of highly hazardous substances. The concentration of formaldehyde – a hazard category 2 substance – in sewer network emissions (using direct measurement) and in the underroof space of sewer collectors (by a calculation) was experimentally investigated. The calculations were carried out based on the measurements of the concentration of formaldehyde in the emissions and the data collected during special laboratory experiments with polymer coatings, which accumulated organic gaseous compounds from being in the sewers. It has been proved that the concentration of formaldehyde in the underroof space and in sewer network emissions significantly exceeds the corresponding maximum permissible concentration. Cooling and installation of degassers in shafts were suggested as reasonable methods for protecting the city’s atmospheric air against the emissions from sewer systems.
Formation of atrium spaces in the urban environment
Authors: Solobay P A , Vakhnichenko O V 
Published: August 2020

Abstract
This article addresses characteristics of interactions between an atrium space and the urban environment. Renewal and transformation of urban areas over time become urgent problems which solution affects further development and preservation of the uniqueness of environment. The urban environment serves as a basis for a new spatial structure – an atrium space – formed as a centre of social activity. It contributes to the improvement of the level of comfort of the existing urban built-up area by including additional elements of the environment, new functional centres and communication linkages in the urban interior. The formation of an atrium space involves the development of a design solution based on the proposed principles of composition and planning, including “Concentration”, “Combination”, “Integration” and the “City Hall” principles. In the high-density urban environment, it is advisable to apply the “New-in-the-Old” and “New Inside” principles. The use of atrium spaces in the urban environment opens up new opportunities for existing building system and its components without compromising buildings’ uniqueness.
Modern trends at natural and wastewater treatment plants reconstruction
Authors: Martynov S , Kvartenko O , Kovalchuk V , Orlova A 
Published: August 2020

Abstract
This article discusses ways to intensify the natural water treatment plants operation using foamed polystyrene as a contact and filtering medium for bioreactors and filters. The reagent schemes with polystyrene foam filters are offered for the surface water treatment. The improved physicochemical and biological methods for slightly acidic and neutral groundwater preparation are recommended to use. The use of ferrobacteria metabolism products for the ammonium nitrogen oxidation in a slightly acidic medium was investigated. The x-ray spectral analysis of bio-minerals matrix structures was conducted. The reasons of unsatisfactory technical condition of sewage treatment plants in Ukraine were analyzed. The ways of increasing their work efficiency using sedimentation aerotanks of large hydraulic height and using the simultaneous nitrification-denitrification were offered.
Acoustic loading in modern city as negative factor of sustainable development
Authors: Samokhvalova A I , Iurchenko V O , Onyshchenko N G , Kosenko N O 
Published: August 2020

Abstract
At the present time, acoustic contamination is one of the largest ecological problems, which people face with in a big city. It is impossible to eliminate road traffic noise, thus regulation and limitation of environmental noise pollution are important and obligatory actions. Noise can negatively affect human health, vegetal and animal world. Its harm depends on intensity, frequency and duration. Under the current conditions noise control is technically complicated, complex and economically wildly expensive. The study of noise level was performed in the territories, boarded on main traffic arteries of Kharkiv without rail transport and with rail transport. The studies showed that the roads with rail transport are 7-14 dB louder than the roads without it. The average noise level on highways of the city ranged 80-94 dB, besides on some of the highways the average noise level did not reach the statutory level at 100 m from traffic roads. Such noise load level in the urban environment requires implementation of solutions, directed at its reduction. The impact of the noise barrier and green planting on noise emission is studied.
Lattice thermal conductivity of pure and doped (B, N) Graphene
Authors: Mann Sarita , Mudahar Isha , Sharma Hitesh , Jindal V K , Dubey Girija S , Gumbs Godfrey , Fessatidis Vassilios 
Published: August 2020

Abstract
In this paper, the effect of B and N doping on the phonon induced thermal conductivity of graphene has been investigated. This study is important when one has to evaluate the usefulness of electronic properties of B and N doped graphene. We have performed the calculations by employing density functional perturbation theory(DFPT) to calculate the inter-atomic forces/force constants of pristine/doped graphene. Thermal conductivity calculations have been carried out by making use of linearized Boltzmann transport equations (LBTE) under single-mode relaxation time approximation(RTA). The thermal conductivity of pristine graphene has been found to be of the order of 4000 W/mK at 100 K, which decreases gradually with an increase in temperature. The thermal conductivity decreases drastically by 96% to 190 W/mK when doped with 12.5% B and reduces by 99% to 30 W/mK with 25% B doping. When graphene is doped with N, the thermal conductivity decreases to 4 W/mK and 55 W/mK for 12.5% and 25% doping concentration, respectively. We have found that the thermal conductivity of doped graphene show less sensitivity to change in temperature. It has also been shown that the thermal conductivity of graphene can be tuned with doping and has a strong dependence on doping concentration.
Investigation of wear resistance for variable configurations of woven glass-fiber reinforced composite materials
Authors: Al-Tameemi Hamza Abdulrasool , Ali Ahmed Abdul Hussain , Hussein Ban 
Published: August 2020

Abstract
Glass fiber composites are widely used in different engineering applications due to their valuable properties of superior weight and strength compared with metals. The tribological properties of these composites vary significantly with the operational conditions and fiber distribution. In this study three orthogonally aligned and chopped fibers were used to manufacture four types of composites with similar volume fraction. The orthogonal (woven) fibers have three different configurations with different width of warp and weft and different aligning distance. Weight loss under dry contact was examined using a tribometer (ASTM G65) with a flat specimen on a steel ring. This study showed that for the composite with the thinnest warps and wefts, and those with the largest distance between adjacent yarns, Archard wear coefficient was the lowest and this also corresponded the lowest weight or volume loss at all speeds. It was found that toughness can specify the wear resistance more than hardness. Only the composite with chopped glass fiber showed a steady wear rate with sliding speed, while the wear rate for the composite with woven fibers increases with sliding speed. The wear mechanism was mainly by the formation and removal of a brittle layer that appeared as a result of friction heat, and this caused partial cutting and removal of the fibers. The penetration of resin into the woven matrix is more important for higher wear resistance than the density of the yarns in the woven fibers.
Quantum addition imparts less disorder than mixing and commutes with incoherent channels
Authors: Mukhopadhyay Chiranjib , Pati Arun Kumar , Sazim Sk 
Published: August 2020

Abstract
We prove a generalized version of a previously conjectured inequality by Zhang et al (Zhang et al 2018 Phys. Lett. A 382, 1516–23) for the quantum addition operation defined by Datta et al (Audenaert et al 2016 J. Math. Phy.
57, 052202) in the context of proving an entropy power inequality for qubits. We also show that the quantum addition operation commutes with an incoherent channel, which may have possible implications for resource theories of coherence in optical settings.
Effectiveness of virtual reality technology on functional mobility of older adults: systematic review and meta-analysis
Authors: Corregidor-Sánchez Ana Isabel , Segura-Fragoso Antonio , Rodríguez-Hernández Marta , Jiménez-Rojas Concepción , Polonio-López Begoña , Criado-Álvarez Juan José 
Published: August 2020

Abstract

Background
The accessibility, versatility and motivation provided by virtual reality technology (VRT) have fostered its rapid expansion as a rehabilitation technique to improve functional mobility. The aim of this study was to investigate the effectiveness of rehabilitation programmes using VRT, specific virtual reality technology (VRT-S) and non-specific virtual reality technology (VRT-NS), to improve functional mobility in individuals aged &gt;60 years versus conventional treatment (CT) or no intervention.

Methods
Nine databases (Cochrane Library, Scopus, PEDro, Medline, CSIC, Web of Science, OT Seeker, NGCH and CINAHL) were searched to identify randomised trials up to December 2019. Results of clinical trials that used VRT-S and VRT-NS in rehabilitation were combined, using a random effects model with inverse variance weighting of the studies. GRADE was used to assess the quality of evidence. The protocol was registered in PROSPERO: CRD42019131630. Overall, there was moderate quality of evidence for the functional mobility results, which means that the estimate of effect is likely to change.

Results
Sixteen of the 18 studies selected (n = 568) provided data for the subgroup meta-analysis. VRT-NS was more effective in improving functional mobility than no intervention [standardised mean difference (SMD) = –1.02; 95% confidence interval (CI) −1,91 to −0,14). VRT-NS was also more effective than CT in improving resistance in ambulation (SMD = −1.20; 95% CI –1.93 to 0.46). No significant differences were found between VRT-S and CT or no intervention. Programmes in which &gt;18 sessions were applied were more beneficial (SMD = −0.89; 95% CI –1.71 to –0.08; &lt;0.001) than programmes with ≤18 sessions (SMD = 0.04; 95% CI –0.51 to 0.59) versus no intervention.

Conclusions
Our results suggest that VRT is an effective intervention for improving functional mobility in older persons compared with CT. VRT-NS proved to be more effective than VRT-S. However, these results are still not conclusive due to the low methodological quality of the studies. Thus, new studies and analyses are required.
Characterizing therapeutic signatures of transcription factors in cancer by incorporating profiles in compound treated cells
Authors: Jung Jinmyung 
Published: August 2020

Abstract

Motivation
Cancers are promoted by abnormal alterations in biological processes, such as cell cycle and apoptosis. An immediate reason for those aberrant processes is the deregulation of their involved transcription factors (TFs). Thus, the deregulated TFs in cancer have been experimented as successful therapeutic targets, such as RARA and RUNX1. This therapeutic strategy can be accelerated by characterizing new potential TF targets.

Results
Two kinds of therapeutic signatures of TFs in A375 (skin) and HT29 (colon) cancer cells were characterized by analyzing TF activities under effective and ineffective compounds to cancer. First, the therapeutic TFs (TTs) were identified as the TFs that are significantly activated or repressed under effective compared to ineffective compounds. Second, the therapeutically correlated TF pairs (TCPs) were determined as the TF pairs whose activity correlations show substantial discrepancy between the effective and ineffective compounds. It was facilitated by incorporating (i)compound-induced gene expressions (LINCS), (ii) compound-induced cell viabilities (GDSC) and (iii) TF–target interactions (TRUST2). As a result, among 627 TFs, the 35 TTs (such as MYCN and TP53) and the 214 TCPs (such as FOXO3 and POU2F2 pair) were identified. The TTs and the proteins on the paths between TCPs were compared with the known therapeutic targets, tumor suppressors, oncogenes and CRISPR-Cas9 knockout screening, which yielded significant consequences. We expect that the results provide good candidates for therapeutic TF targets in cancer.

Availability and implementation
The data and Python implementations are available at https://github.com/jmjung83/TT_and_TCP.

Supplementary information
Supplementary data are available at Bioinformatics online.
Identifying signaling genes in spatial single-cell expression data
Authors: Li Dongshunyi , Ding Jun , Bar-Joseph Ziv 
Published: August 2020

Abstract

Motivation
Recent technological advances enable the profiling of spatial single-cell expression data. Such data present a unique opportunity to study cell–cell interactions and the signaling genes that mediate them. However, most current methods for the analysis of these data focus on unsupervised descriptive modeling, making it hard to identify key signaling genes and quantitatively assess their impact.

Results
We developed a Mixture of Experts for Spatial Signaling genes Identification (MESSI) method to identify active signaling genes within and between cells. The mixture of experts strategy enables MESSI to subdivide cells into subtypes. MESSI relies on multi-task learning using information from neighboring cells to improve the prediction of response genes within a cell. Applying the methods to three spatial single-cell expression datasets, we show that MESSI accurately predicts the levels of response genes, improving upon prior methods and provides useful biological insights about key signaling genes and subtypes of excitatory neuron cells.

Availability and implementation
MESSI is available at: https://github.com/doraadong/MESSI

Supplementary information
Supplementary data are available at Bioinformatics online.
Visual and Semantic Representations Predict Subsequent Memory in Perceptual and Conceptual Memory Tests
Authors: Davis Simon W , Geib Benjamin R , Wing Erik A , Wang Wei-Chun , Hovhannisyan Mariam , Monge Zachary A , Cabeza Roberto 
Published: August 2020

AbstractIt is generally assumed that the encoding of a single event generates multiple memory representations, which contribute differently to subsequent episodic memory. We used functional magnetic resonance imaging (fMRI) and representational similarity analysis to examine how visual and semantic representations predicted subsequent memory for single item encoding (e.g., seeing an orange). Three levels of visual representations corresponding to early, middle, and late visual processing stages were based on a deep neural network. Three levels of semantic representations were based on normative observed (“is round”), taxonomic (“is a fruit”), and encyclopedic features (“is sweet”). We identified brain regions where each representation type predicted later perceptual memory, conceptual memory, or both (general memory). Participants encoded objects during fMRI, and then completed both a word-based conceptual and picture-based perceptual memory test. Visual representations predicted subsequent perceptual memory in visual cortices, but also facilitated conceptual and general memory in more anterior regions. Semantic representations, in turn, predicted perceptual memory in visual cortex, conceptual memory in the perirhinal and inferior prefrontal cortex, and general memory in the angular gyrus. These results suggest that the contribution of visual and semantic representations to subsequent memory effects depends on a complex interaction between representation, test type, and storage location.
Impact of protein glycosylation on lipoprotein metabolism and atherosclerosis
Authors: Pirillo Angela , Svecla Monika , Catapano Alberico Luigi , Holleboom Adriaan G , Norata Giuseppe Danilo 
Published: August 2020

Abstract
Protein glycosylation is a post-translational modification consisting in the enzymatic attachment of carbohydrate chains to specific residues of the protein sequence. Several types of glycosylation have been described, with N-glycosylation and O-glycosylation being the most common types impacting on crucial biological processes, such as protein synthesis, trafficking, localization, and function. Genetic defects in genes involved in protein glycosylation may result in altered production and activity of several proteins, with a broad range of clinical manifestations, including dyslipidaemia and atherosclerosis. A large number of apolipoproteins, lipoprotein receptors, and other proteins involved in lipoprotein metabolism are glycosylated, and alterations in their glycosylation profile are associated with changes in their expression and/or function. Rare genetic diseases and population genetics have provided additional information linking protein glycosylation to the regulation of lipoprotein metabolism.