bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eficacia de la férula nocturna y el ultrasonido para tratar el síndrome del túnel carpiano. Estudio clínico controlado y aleatorizado
Authors: Hernandez Daniel , Terpolilli Esteban , Verdecchia Daniel Héctor , Leiva Valeria , Ventos Laura , Rodríguez Romina , Gamboa Anabella , Spath María Belén , Steimberg Jimena , Sanz Martín , Williams Erica , Mohr Sabrina , Colesnik Paola , Chen Tai Lo , Dell' Era Silvina , Dimaro Mariana , Díaz Romina , Baldo Bruno , Accoce Matías 
Published: November 2020

Objetivo: Comparar la eficacia de la inmovilización nocturna de la muñeca con una férula cubital en ángulo neutro junto con la aplicación de ultrasonido en pacientes con síndrome del túnel carpiano leve y moderado. Materiales y Métodos: Entre octubre de 2007 y marzo de 2010, se incluyó a pacientes >18 años con síndrome del túnel carpiano confirmado por electromiografía en un hospital de Buenos Aires. Se realizó una aleatorización estratificada, con bloques permutados aleatorios, y apareamiento por sexo y edad. Los pacientes fueron asignados al grupo experimental (GE) o al grupo de control (GC). Ambos grupos recibieronultrasonido de 1 MHz pulsante por 15 min, 3 veces por semana, durante 6 semanas. Los pacientes del GE, además, utilizaron una férula nocturna. Se evaluaron el dolor y la parestesia con la escala analógica visual de 100 mm, la PSFS y el test de Moberg, al comenzar, a las 3 semanas y, al finalizar, a las 6 semanas, y durante el seguimiento, al mes, y a los 3 y 6 meses, con evaluador a ciego. Resultados: Se analizó a 32 pacientes del GC y a 33 del GE. Al finalizar el tratamiento, todas las variables habían mejorado en ambos grupos, con diferencia de medias estadísticamente significativa para el dolor a favor del GE a las 3 semanas de tratamiento 1,64 (IC95% 0,38-2,91; p = 0,012), pero sin diferencia clínica significativa. No se informaron efectos adversos. Conclusión: El tratamiento con una férula nocturna y ultrasonido no es superior al ultrasonido solo en pacientes con STC.
Palabras clave: Síndrome del túnel carpiano; tratamiento; férulas; terapia con ultrasonido.Nivel de Evidencia: II
The effect of miR-101 on the memory of rats with a model of Alzheimer’s disease
Authors: Berchenko O. G. , Levicheva N. O. , Bevzyuk D. O. , Sokolik V. V. 
Published: November 2020

Memory impairment is a hallmark of Alzheimer’s disease. The clinical diagnosis of the disease is made in the later stages of its development, when specific therapy of the disease is not always effective. Therefore, the detection of early behavioral manifestations of memory disorders in the development of the disease will allow the use of preventive therapy aimed at stopping the death of neurons in brain structures. A neuroethological study of working, spatial, and emotional memory was performed in rats 15–16 months of age with a model of early manifestations of Alzheimer’s disease induced by stereotactic administration of β-amyloid peptide 40 aggregates into the hippocampus. Changes in the neuroethological components of working and spatial memory have been identified. Testing of working memory showed a violation in rats of recognizing the shape of identical objects, reducing experimental activity to unfamiliar objects and their differentiation. Spatial orientation disorders have been identified in the Barnes labyrinth. Emotional memory research has shown the preservation of innate forms of protective adaptive behaviour. At the same time, vegetative indicators reflected an increase in emotional tension. Intranasal administration of liposomal miRNA miR-101 involved in liposomes to rats with a model of early manifestations of Alzheimer’s disease improved neuroethological parameters of working and spatial memory. Restoration of the level of research activity and differentiation of familiar and unfamiliar objects in the testing of working memory in rats has been established. Spatial memory in Barnes labyrinth testing was improved by reproducing spatial orientation skills and relieving emotional stress. Thus, the intranasal use of miR-101 in Alzheimer’s disease is a promising approach to prevent the development of amyloidosis and preserve memory in the early manifestations of Alz-heimer’s disease.
Potential role of cytoplasmic protein binding to erythrocyte membrane in counteracting oxidative and metabolic stress
Authors: Dotsenko O. I. , Mykutska I. V. , Taradina G. V. , Boiarska Z. O. 
Published: November 2020

The ability of protein to reversibly bind with membrane components is considered to be one of the oldest mechanisms of cell response to external stimuli. Erythrocytes have a well-developed mechanism of an adaptive response involving sorption-desorption processes, e.g. interactions of key glycolytic enzymes and hemoglobin with band 3 protein. A few publications have shown that under oxidative stress, cytoplasmic enzymes such as catalase, glutathione peroxidase and рeroxiredoxin bind to the erythrocyte membrane. The present work is a continuation of research in this direction to determine the causes and consequences of the interaction of cytoplasmic proteins with the membrane under conditions of oxidative stress and different glucose content. Human erythrocytes were incubated for five hours at 20 °C in an oxidizing medium of AscH – 1 · 10–4 M, Cu2+– 5 · 10–6 M with different glucose content (0–8 mM). Dynamic changes in the accumulation of membrane-bound hemoglobin, the distribution of ligand forms of hemoglobin in the cytoplasmic and membrane-bound fractions, the activity of membrane-associated and cytoplasmic forms of Cu/Zn superoxide dismutase (SOD1) and catalase, H2O2 content in extracellular and intracellular media were recorded. It was shown that binding of catalase and SOD1 to the erythrocyte membrane is initiated by oxidative stress and is a physiological function aimed at complete inactivation of extracellular and H2O2 and protection against their entry into the cell. It was shown that under conditions of glucose depletion and oxidative loading, catalase and SOD1 bind to the erythrocyte membrane, leading to inactivation of these enzymes. Membrane-bound hemoglobin was higher in cells incubated under these conditions than in glucose experiments. Glucose introduced into the incubation medium in an amount 4–8 mM causes complete binding of SOD1 to the membrane of erythrocytes, by involving it in the processes of casein kinase stabilization and glycolytic fluxes regulation. With mild oxidation, the amount of hemoglobin bound to the membrane does not change, indicating the presence of certain binding sites for hemoglobin with membrane proteins. We show that the activity of membrane-bound SOD1 along with the content of ligand forms in the composition of membrane-bound hemoglobin are informative indicators of the metabolic and redox state of erythrocytes.
La recepción de la Revolución Mexicana en América del Sur
Authors: Palacios Guillermo 
Published: November 2020

Este texto analiza la reacción de los gobiernos y, en menor medida, de la opinión pública de los países sudamericanos más activos políticamente, frente a los movimientos revolucionarios de México durante la década de 1910, y acompaña su comportamiento ante el desarrollo de los procesos reformistas, marcadamente de izquierda, que inician en 1920 y se prolongan hasta los años de la Guerra Civil en España. El argumento central propone que los gobiernos sudamericanos, la mayor parte de ellos de orientación oligárquico-derechista y firmes aliados de Estados Unidos, mantuvieron misiones diplomáticas en México en razón de la conversión del país en un laboratorio de reformas radicales izquierdistas que podrían fácilmente extenderse al resto del continente. Era necesario contar con el mayor volumen de información posible para evitar el contagio. Se enfatiza también la oportunidad que la llamada ‘Revolución Mexicana’ representó para los fallidos esfuerzos de consolidación del bloque de Argentina, Brasil y Chile, el ABC, como la formación política hegemónica de América Latina, y el papel que el caldeado ambiente político de la ciudad de México tuvo en la re-escenificación de las viejas disputas territoriales sudamericanas.
Migración, mestizaje y xenofobia en México (1910-1950)
Authors: Yankelevich Pablo 
Published: November 2020

En México, la población de origen extranjero ocupa un lugar marginal en la composición demográfica del país. A pesar de que los gobiernos siempre admitieron la importancia de atraer inmigrantes, México ha tenido una de las políticas inmigratorias más restrictivas de América Latina. ¿Cómo explicar esta paradoja? Para responder esta pregunta, este artículo explora la construcción de la figura del mestizo como fundamento de la nación mexicana. Interesa mostrar que esa figura se acrecentó por el ascenso del pensamiento nacionalista producto de la Revolución de 1910 y por el impacto de procesos migratorios que generó la vecindad Estados Unidos de América. Estos asuntos cimentaron discursos, normas y acciones xenófobas que, con intensidades distintas, impregnaron la relación entre México y los extranjeros.
Soil Quality Indicators Associated With The Application Of Mycorrhizal Fungi In Coffee Plantations
Authors: Avila Bayona Catherine Paola 
Published: November 2020

Introduction: This article is the result of the research work “Evaluation of the quality of the soil associated with the use of mycorrhizae in coffee plantations in the Municipality of Sasaima, Cundinamarca” carried out duringthe years 2018 and 2019 at the Universidad Libre.
Problem: Several investigations report the use of mycorrhizal fungi in plant development, however, there are few studies regarding the relationship between mycorrhizae and soil quality indicators.
Methodology: Four plots were evaluated, applying: 1) Control; 2) Local native mycorrhizae isolated by the authors; 3) Commercial liquid mycorrhizae; and 4) Commercial solid mycorrhizae. The samples of the rhizosphericsoils were taken and bimonthly monitoring was applied until 5 collection cycles were obtained. The physicochemical parameters, abundance of functional groups of microorganisms, and enzymatic activities ofthe soil were determined and analyzed by means of univariate and multivariate statistical analysis.
Conclusion: The research hypothesis was validated since the mycorrhizae inoculation significantly increased the values of the soil quality indicators, namely organic carbon (14%), moisture (19%), phosphorus (30%), abundanceof nitrogen-fixing bacteria (5.5%), phosphate-solubilizing bacteria (7.8%), cellulolytic bacteria (9.3%), and phosphate-solubilizing fungi (2.6%). In addition, the local native mycorrhizae that were isolated by theauthors showed greater benefits than those of the commercial mycorrhizae.
Originality: This research reveals the impact of mycorrhizae on the soil quality indicators over time during thefirst year of application, especially on the microbial and enzymatic parameters.
Limitations: Several authors have investigated the importance of the mycorrhizae on the physicochemical parameters of the plant, and not on the microbial and enzymatic parameters of the soil.
Diagnosis Of Hospital, Hazardous and Similar Waste Management of an Institution Providing Health Services – IPHS
Authors: Aparicio Plazas David Eduardo , Angulo Flórez Diego Hernando , Cipagauta Esquivel Edna Carolina , Barragán Currea Diego Alejandro , Zipa Romero Rosmy Johana 
Published: November 2020

Introduction: This article presents the results of the research carried out from January 2018 to December 2019, in an institution providing third-level health services (IPHS), located in Tunja (Boyacá), in eastern central Colombia.
Problem: There are various difficulties related to the management of waste produced by the IPHS; Irresponsible practices cause the spread of infections, which have repercussions in critical situations locally, regionally and internationally.
Objective: To evaluate the management of hospital, hazardous and similar waste (HCWM), carried out by an IPHS, and to formulate strategies for its improvement.
Methodology: The research was carried out in three (3) stages: data collection (through inspections and weighing of waste), data analysis (for the qualification and quantification of the waste), and finally, some guidelines for its proper management were proposed, based on the context of the organization.
Results: The IPHS generated 397.6 tonnes of hospital, hazardous and similar waste (MW). Biohazard waste (BW) predominated over the others (54.11%), followed by usable non-hazardous waste - UNHW (41.53%) and chemical and pharmaceutical waste - CPW (4, 37%).
Conclusion: The entity complies with the main requirements of the national government, identifying good utilization and biosecurity practices; however, under diagnosis and with the implementation of guidelines emanating from research, it is possible to optimize procedures.
Originality: The guidelines and activities for the separation, use and internal collection of waste within an IPHS were observed and then interrelated with the services provided and their resources. This work could be a guideline for related institutions.
Limitations: The article focuses on the internal and non-external management of MW.
Implementing an Influenza Vaccine Effectiveness Study in a Hospital Context in Portugal: The EVA Hospital Project
Authors: Machado Ausenda , Gomez Verónica , Panarra António , Poças Jose , Corte-Real Rita , Peres Maria João , Nunes Baltazar , EVA Hospital Group Em Representação do 
Published: November 2020

Introduction: The project ‘Integrated Monitoring of Vaccines in Europe’ aimed to measure seasonal influenza vaccine effectiveness against hospitalised adults, aged 65 years and over, with influenza. We describe the protocol implementation in Portugal.Material and Methods: We implemented a test-negative design, targeting community-dwelling patients aged 65 years old and over hospitalised with severe acute respiratory illness. Patients were reverse transverse-polymerase chain reaction tested for influenza. Cases were those positive for influenza while others were controls. Most variables were collected using hospital medical records. Selection bias was evaluated by comparison with the laboratory influenza test requests database according to demographic characteristics. Crude, season-adjusted influenza vaccine effectiveness was estimated as = 1 – odds ratio, and 95% confidence intervals were obtained by conditional logistical regression, matched with the disease onset month.Results: The recruitment rate was 37.8%. Most participants (n = 368) were female (55.8%) and aged 80 years old and over (55.8%). This was similar to values for potentially eligible severe acute respiratory illness patients (80 years old and over: 56.8%, female: 56.2%). The proportion of missing values was below 2.5% for 20 variables and above 5% (maximum 11.6%) for six variables. Influenza vaccine effectiveness estimates were 62.1% against AH1pdm09 (95% confidence intervals: -28.1 to 88.8), 14.9% against A(H3N2) (95% confidence intervals: -69.6 to 57.3), 43.6% against B/Yam (95% confidence intervals: -66.2 to 80.8).Discussion: Given the non-existence of a coded admission database in either participating hospital the selection of severe acute respiratory illness due to clinical features was the feasible one. These results are only valid for the older adult population residing in the catchment area of the two participating hospitals who were admitted to a public hospital with severe influenza or SARI symptoms.Conclusion: Despite the low participation rate, we observed comparable characteristics of participants and eligible severe acute respiratory illness patients. Data quality was high, and influenza vaccine effectiveness results were in accordance with the results of meta-analyses and European season-specific estimates. The final sample size was low, which inhibited obtaining estimates with good precision.
The Description of the Application of Healthy Workplaces at PT PJB Power Plant Unit Gresik
Authors: Pratiwi Dinda Ocvita Windi 
Published: November 2020

Introduction: Healthy workplaces is a concept where everyone in the work environment works together to achieve the vision of the health and welfare of workers and the surrounding community. PT PJB UP Gresik is a supplier of electrical energy since 14th June 1996, and has received top management awards in 2018 with zero accidents in 2018 and 2019. This study aimed to describe the working environment of PT PJB UP Gresik using Healthy Workplaces Theory. Methods: The study was conducted in February-August 2019 through descriptive of quantitative method. The population involved was 325 workers selected using simple random sampling, divided into two groups of 22 managements, and 76 staffs. Research tool used was in the form of WHO questionnaire. The study passed the ethical review of the Faculty of Dentistry, Universitas Airlangga in June 2019 number 324/HRECC.FODM/VI/2019. Result: As much as 97% of the management and 76% of staff agreed that the company had health-oriented regulations. It also obtained that 100% management, and 92% staff agreed that the company's psychosocial environment was healthy. As much as 96% of each respondent group agreed that the work environment was safe. About 63% management and 64% staff agreed that the company supported changes in healthy lifestyles. Around 60% management and 64% staff agreed that the company's health service units were available and implemented well. The statement of company being a good effect has been approved by 89% of the management. Conclusion: PT PJB UP Gresik has a healthy work environment and can be improved if it pays more attention to the lifestyle and the functions of health service.Keywords: heat radiation, noise, ship production
Adolescent Birth Rates and Rural–Urban Differences by Levels of Deprivation and Health Professional Shortage Areas in the United States, 2017–2018
Authors: Orimaye Sylvester O. , Hale Nathan , Leinaar Edward , Smith Michael G. , Khoury Amal 
Published: November 2020

Objectives. To examine the differences in adolescent birth rates by deprivation and Health Professional Shortage Areas (HPSAs) in rural and urban counties of the United States in 2017 and 2018. Methods. We analyzed available data on birth rates for females aged 15 to 19 years in the United States using the restricted-use natality files from the National Center for Health Statistics, American Community Survey 5-year population estimates, and the Area Health Resources Files. Results. Rural counties had an additional 7.8 births per 1000 females aged 15 to 19 years (b = 7.84; 95% confidence interval [CI] = 7.13, 8.55) compared with urban counties. Counties with the highest deprivation had an additional 23.1 births per 1000 females aged 15 to 19 years (b = 23.12; 95% CI = 22.30, 23.93), compared with less deprived counties. Rural counties with whole shortage designation had an additional 8.3 births per 1000 females aged 15 to 19 years (b = 8.27; 95% CI = 6.86, 9.67) compared with their urban counterparts. Conclusions. Rural communities across deprivation and HPSA categories showed disproportionately high adolescent birth rates. Future research should examine the extent to which contraceptive access differs among deprived and HPSA-designated rural communities and the impact of policies that may create barriers for rural communities.
Patient and health system factors associated with pretreatment loss to follow up among patients diagnosed with tuberculosis using Xpert® MTB/RIF testing in Uganda
Authors: Zawedde-Muyanja Stella , Katamba Achilles , Cattamanchi Adithya , Castelnuovo Barbara , Manabe Yukari C 
Published: November 2020

Abstract
Background: In 2018, Uganda started only 65% of persons with incident tuberculosis on treatment. Pretreatment loss to follow up is an important contributor to suboptimal treatment coverage. We aimed to describe the patient and health facility-level characteristics associated with pretreatment loss to follow up among patients diagnosed with pulmonary tuberculosis at public health facilities in Uganda. Methods: At ten public health facilities, laboratory register data was used to identify patients aged 15 years who had a positive Xpert®MTB/RIF test. Initiation on TB treatment was ascertained using the clinical register. Factors associated with not being initiated on TB treatment within two weeks of diagnosis were examined using a multilevel logistic regression model accounting for clustering by health facility. Results:From January to June 2018, 510 patients (61.2% male and 31.5% HIV co-infected) were diagnosed with tuberculosis. One hundred (19.6%) were not initiated on TB treatment within two weeks of diagnosis. Not having a phone number recorded in the clinic registers (aOR 7.93, 95%CI 3.93-13.05); being HIV-infected (aOR 1.83; 95% CI: 1.09-3.26) and receiving care from a high volume health facility performing more than 12 Xpert tests per day (aOR 4.37, 95%CI 1.69-11.29) and were significantly associated with pretreatment loss to follow up. Conclusion: In public health facilities in Uganda, we found a high rate of pretreatment loss to follow up especially among TBHIV co-infected patients diagnosed at high volume health facilities. Interventions to improve the efficiency of Xpert® MTB/RIF testing, including monitoring of the TB care cascade should be developed and implemented.
Behavioral Profile, Lifestyle and Social Skills in Portuguese Adolescents
Authors: Magalhães Clarisse , Ribeiro Maria de Fátima , Esteves Maria Raquel , Aires Luísa , Lima Sara , Silva Gustavo , Nogueira Assunção , Herdeiro Maria Teresa , Pedras Susana 
Published: November 2020

Abstract
Background: Seventy percent of premature deaths in adults are due to behaviors initiated during adolescence. Therefore, it is essential to promote individual and social behaviors that educate adolescents in the ability to make healthy choices. Accordingly, the main goals of this study were to characterize Lifestyles and Social Skills, as well as identify homogeneous subgroups, in a sample of Portuguese adolescents. Methods: A cross-sectional study was conducted, including 1008 adolescents attending the 7th to the 9th grades of five middle schools from the Tâmega and Sousa regions of Portugal, and using the My Lifestyle Questionnaire and the Social Skills Inventory. To establish a profile of the participants, a Cluster Analysis (K-means) was performed, and the Jaccard coefficient was used to assess the stability of the solution found. Results: From the total sample, 556 adolescents with a mean age of 13.43 years (SD=1.1) were included in the analysis. The majority of the sample presented a healthy lifestyle (72.26%) and 50.7% of the adolescents had a highly elaborated repertoire of Social Skills. Moreover, three clusters were found. Cluster 1 (n=92) showed a less elaborate repertoire of Social Skills and was designated as the “Adjusted”. Cluster 2 (n=115) comprised adolescents with a good repertoire of Social Skills and was named the “Sociable”. Cluster 3 (n=258) was composed of adolescents with a highly elaborate repertoire of Social Skills and the best Lifestyle indicators and was named the “Healthy”. Conclusions: The group of adolescents in the cluster called the “Sociable” needs to be included in health education and Social Skills programs. Nutrition and Monitored Safety behaviors reveal low values and, therefore, present a greater need for awareness, sensitization, and intervention in the school context. For this reason, the promotion of a healthy lifestyle should be part of the academic curriculum and transversal to all academic disciplines.