bluuebunny/crossref_metadata_2025_split huggingface dataset:
MMP‐7, ‐8, ‐9, E‐cadherin, and beta‐catenin expression in 34 ameloblastoma cases
Authors: Kelppe Jetta , Thorén Hanna , Haglund Caj , Sorsa Timo , Hagström Jaana 
Published: September 2020

AbstractObjectivesAmeloblastoma is a benign, locally aggressive odontogenic tumor with high recurrence rates. Matrix metalloproteinases (MMPs) mediate extracellular integrity in normal and pathological conditions, and exert multiple functions coordinating inflammation and tumor progression. E‐cadherin and beta‐catenin are adherence junction molecules in cell‐to‐cell connections. We investigated the involvement of MMP‐7, ‐8, ‐9, E‐cadherin, and beta‐catenin in ameloblastoma and the surrounding extracellular matrix.Material and methodsOur material consisted of 30–34 tissue samples from ameloblastoma patients of Helsinki University Hospital. We used immunohistochemistry to detect the expression of the biomarkers. Two oral pathologists independently scored the immunoexpression intensities and statistical calculations were made based on the results.ResultsE‐cadherin expression was weaker in the maxillary than in mandibular ameloblastomas. Beta‐catenin was expressed in the ameloblastoma cell membranes. We detected MMP‐8 and ‐9 expression in polymorphonuclear neutrophils in the extracellular area and these MMPs correlated positively with each other. Osteoclasts lining bone margins and multinuclear giant cells expressed MMP‐9. Neither MMP‐8 nor MMP‐9 immunoexpression could be detected in ameloblastoma cells. MMP‐7 expression was seen in some apoptotic cells.ConclusionThe fact that E‐cadherin immunoexpression was weaker in maxillary compared to mandibular ameloblastomas might associate to earlier recurrences. It promotes the idea of mandibular and maxillary ameloblastoma exerting differences in their biologies. We detected MMP‐8 and ‐9 in polymorphonuclear neutrophils which relates to these MMPs participating in extracellular remodeling through a mild inflammatory process. Bone degradation around ameloblastoma may be due to MMP‐9 in osteoclasts but this phenomenon might be an independent process and needs further investigations.
Structural Stabilization of P2‐type Sodium Iron Manganese Oxides by Electrochemically Inactive Mg Substitution: Insights of Redox Behavior and Voltage Decay
Authors: Yang Junghoon , Maughan Annalise E. , Teeter Glenn , Tremolet de Villers Bertrand J. , Bak Seong‐Min , Han Sang‐Don 
Published: September 2020

AbstractLayered P2‐type Na0.8Mn0.5Fe0.5O2 cathode material is a promising candidate for next‐generation sodium‐ion batteries due to the economical and environmentally benign characteristics of Mn and Fe. The poor cycling stability of the material, however, is still a problem that must be solved. To address the problem, electrochemically inactive Mg2+ was introduced into the structure by substituting some of the Fe ions. It was shown that Mg substitution led to a smoother voltage profile with improved cycling performance and rate capability. These observations were attributed to the suppressed structural changes during electrochemical processes. Detailed redox mechanisms, associated local structural changes, and phase transitions were investigated by X‐ray absorption spectroscopy and X‐ray diffraction. From the detailed analysis of electrochemical behaviors, it was also identified how the redox reactions and structural disordering occurred in the high‐ and low‐voltage regions and how Mg substitution stabilized the structure.
Ultraefficient imprecise multipliers based on innovative 4:2 approximate compressors
Authors: Khaleqi Qaleh Jooq Mohammad , Ahmadinejad Mohammad , Moaiyeri Mohammad Hossein 
Published: September 2020

SummaryThis study proposes two ultraefficient imprecise multipliers based on innovative 4:2 approximate compressor designs. The first proposed multiplier employs an ultracompact 8‐transistor 4:2 compressor to reduce the transistor count and energy dissipation. To improve the accuracy of the first proposed imprecise multiplier, the second multiplier also benefits from a semiaccurate 24‐transistor 4:2 approximate compressor for the high‐order bits. The 7‐nm fin field‐effect transistor (FinFET) technology, as one of the leading commercial technologies, is utilized to simulate the proposed multipliers in the
environment. The simulation results indicate that the proposed imprecise multipliers show significant improvements regarding transistor count, delay, power, and power‐delay product as compared to their state‐of‐the‐art imprecise and exact counterparts. Along with the superior hardware efficiency, the MATLAB simulations demonstrate that the proposed multipliers also provide reasonable levels of accuracy. Moreover, a figure of merit (FOM) considering hardware efficiency and output quality is considered in order to evaluate the multipliers comprehensively. The FOM simulation results indicate that the proposed imprecise multipliers make a significant trade‐off between hardware efficiency and quality for approximate‐computing applications dealing with image multiplication.
SUMOylation of PUM2 promotes the vasculogenic mimicry of glioma cells via regulating CEBPD
Authors: Wang Di , Ruan Xuelei , Liu Xiaobai , Xue Yixue , Shao Lianqi , Yang Chunqing , Zhu Lu , Yang Yang , Li Zhen , Yu Bo , Feng Tianda , Liu Yunhui 
Published: September 2020

AbstractGlioma is the most common form of primary central nervous malignant tumors. Vasculogenic mimicry (VM) is a blood supply channel that is different from endothelial blood vessels in glioma. VM is related to tumor invasion and metastasis. Therefore, it plays an important role to target therapy for glioma VM. Our experimental results showed abnormal expression of UBE2I, PUM2, CEBPD, and DSG2 in glioma cells. The Co‐IP and Immunofluorescence staining were used to detect that PUM2 can be modified by SUMO2/3. The interaction between PUM2 and CEBPD mRNA was detected by the RIP assays. The interaction between transcription factor CEBPD and promoter region of DSG2 was detected by the ChIP assays and luciferase assays. The capacity for migration in glioma cells was observed by the laser holographic microscope. The capacity for invasion in glioma cells was detected by Transwell method. The VM in glioma cells was detected by three‐dimensional cell culture method. The experimental results found that the upregulation of UBE2I in glioma tissues and cells promotes the SUMOylation of PUM2, which decreases not only the stability of PUM2 protein but also decreases the inhibitory effect of PUM2 on CEBPD mRNA. The upregulation of CEBPD promotes the binding to the upstream promoter region of DSG2 gene, further upregulates the expression of DSG2, and finally promotes the development of glioma VM. In conclusion, this study found that the UBE2I/PUM2/CEBPD/DSG2 played crucial roles in regulating glioma VM. It also provides potential targets and alternative strategies for combined treatment of glioma.
Reorganization of action observation and sensory‐motor networks after action observation therapy in children with congenital hemiplegia: A pilot study
Authors: Sgandurra Giuseppina , Biagi Laura , Fogassi Leonardo , Ferrari Adriano , Sicola Elisa , Guzzetta Andrea , Tosetti Michela , Cioni Giovanni 
Published: September 2020

AbstractNew rehabilitation programs based on action observation therapy (AOT) are effective in improving motor function in children with congenital hemiplegia. In this pilot study we tested the potential effects of AOT on the reorganization of the motor system by functional magnetic resonance imaging (fMRI). As part of a randomized trial, eight subjects (age range: 6.2–14.5 years) with congenital hemiplegia were randomly assigned to an experimental (EG) or control (CG) group. All children underwent a clinical and neurophysiological assessment with Assisting Hand Assessment (AHA), MRI, and fMRI at baseline (T0), 1(T1), and 8(T2) weeks after the end of 3‐week treatment. For the EG, AOT consisted in the observation of uni/bimanual goal‐directed actions followed by their execution. CG watched same‐duration computer games and then performed the same actions in the same order used in the EG. fMRI study was carried out using two different paradigms, for exploring sensory‐motor network (SMN) localization and action observation network (AON). The pattern of brain activation was generally similar between T0 and T1 for both groups, while it was more widespread at T2, compared to T0 and T1, in the EG. This enlargement was coupled with functional improvement at AHA. Single‐subject analysis shows a reduction of lateralization indexes both for the AON and the SMN. This pilot study, despite the small sample, showed the fMRI feasibility for providing relevant biomarkers of brain plasticity for monitoring the AOT response in children with congenital hemiplegia. The study was registered at http://www.clinicaltrials.gov (identifier NCT01016496).
Exploring causal components of plasticity in grey seal birthdates: Effects of intrinsic traits, demography, and climate
Authors: Bowen William Don , den Heyer Cornelia E. , Lang Shelley L. C. , Lidgard Damian , Iverson Sara J. 
Published: September 2020

AbstractChange in breeding phenology is often a response to environmental forcing, but less is known of the mechanism underlying such changes and their fitness consequences. Here, we report on changes in the breeding phenology from a 27‐year longitudinal study (1991–2017) of individually marked, known‐aged grey seals (Halichoerus grypus) on Sable Island, Nova Scotia, Canada. We used generalized linear mixed models and a 3‐step process to develop a model that includes interactions between intrinsic and extrinsic covariates and to test hypotheses about the influence of fixed factors (maternal age, parity, previous reproductive success, pup sex, colony density, Atlantic Multidecal Oscillation (AMO), North Atlantic Oscillation (NAO), and Sea Surface Temperature) and a random factor (female identity) on parturition dates. We also examined the consequences of the shift in birthdates on maternal energy allocation in offspring as measured by pup weaning mass. Birthdates were known for 2,768 pups of 660 known‐age females. For 494 females with ≥2 parturition dates, repeatability as measured by the intraclass correlation was high (mean = 0.66). 87% of the variation in birthdates was explained by a mixed‐effects model that included intrinsic and extrinsic fixed effects. Most of the explained variation was associated with the random effect of female identity. Parity was the most important intrinsic fixed effect, with inexperienced mothers giving birth later in the season than multiparous females. Over almost 3 decades, mean birthdates advanced by 15 days. The mixed model with intrinsic effects and population size, the detrended AMO from the previous year and mean NAO in the previous 3 years explained 80% of the variation with 21% of variation from the fixed effects. Both primiparous and multiparous individuals responded to the climate forcing, and there was strong evidence for heterogeneity in the response. Nevertheless, the shift in birthdates did not impact pup weaning mass.
Prevention of diabetic ketoacidosis at diagnosis of type 1 diabetes: Are certified athletic trainers an untapped resource?
Authors: Bogale Kaleb T. , Oser Tamara K. , Zettlemoyer Alexander , Parascando Jessica , Silvis Matthew L. 
Published: September 2020

AbstractAimsTo assess the knowledge of certified athletic trainers (ATs) on the presenting signs and symptoms of type 1 diabetes (T1D).MethodsWe conducted a 31‐question survey of secondary school ATs recruited from the National Athletic Training Association that established demographic information, knowledge of presenting signs and symptoms of T1D, and previous personal or professional exposure to individuals with T1D. We report descriptive statistics and univariate analyses evaluating the characteristics associated with T1D knowledge. We then report a multivariable model incorporating age, gender, years of experience and education level with T1D knowledge as the dependent variable.Results128 participants (92f:34m) met inclusion criteria and were included in this study. The majority of participants correctly identified frequent thirst (96.1%, n = 123) and frequent urination (85.9%, n = 110) as common presenting signs and symptoms of T1D, while fewer participants identified weight gain (58.6%, n = 75) or joint pain (39.1%, n = 50) as incorrect presenting signs and symptoms of T1D. Participants with over ten years of experience or previous exposure to individuals with T1D had increased T1D knowledge. Participants with advanced education (Master's degree or Doctorate) had no statistically significant difference in T1D knowledge compared to those with a Bachelor's degree. The only factor that demonstrated a significant association with T1D knowledge on multivariable analysis was the female gender.ConclusionsEducational awareness campaigns of T1D symptoms to reduce the rate of DKA at diagnosis of T1D have never included ATs. This study illustrates the importance of targeting future educational interventions on newly trained ATs.
Intensity level and cardiorespiratory responses to Baduanjin exercise in patients with chronic heart failure
Authors: Chen Xiankun , Marrone Gaetano , Olson Thomas P. , Lundborg Cecilia Stålsby , Zhu Huiying , Wen Zehuai , Lu Weihui , Jiang Wei 
Published: September 2020

AbstractAimsBaduanjin (eight silken movements), a traditional Chinese exercise, is an alternative to the most common cardiac rehabilitation programmes due to their scarcity and unaffordability in China. The aim of this study was to measure the intensity and energy expenditure during Baduanjin and to determine the relative oxygen consumption (VO2) and heart rate (HR) responses of Baduanjin compared with maximal capacity in patients with chronic heart failure.Methods and resultsTwenty participants (age: 65 ± 10 years, male: n = 17) with New York Heart Association II–III volunteered for this study. Participants were examined during two separate sessions, with 1–2 weeks between sessions. During session one, a symptom‐limited cardiopulmonary exercise testing was performed on a cycle ergometer for measurement of maximal exercise capacity. Additionally, participants were taught Baduanjin exercise from a professional coach and were required to do it at home until the second session when their technique was confirmed by the coach. During session two, participants performed one 9 min round of Baduanjin with continuous measurement of VO2 and HR. Measurements obtained during the Baduanjin were compared with data obtained during cardiopulmonary exercise testing. While performing Baduanjin, the mean VO2 and HR were 7.1 ± 1.2 mL/kg/min and 86.1 ± 15.2 b.p.m., respectively. Compared with the cardiopulmonary exercise test, the VO2 was 44% of their VO2max and 67% of their HRmax, categorizing Baduanjin as a moderate‐intensity exercise. The average energy expenditure during Baduanjin was 23.3 ± 4.4 kcal. Additionally, the VO2 and HR responses during Baduanjin both exhibited a bimodal pattern.ConclusionsThe results suggest that Baduanjin is a moderate‐intensity aerobic exercise that could be an effective and safe exercise modality for home‐based cardiac rehabilitation.
Characterization and Validation of a Platinum Paper‐based Potentiometric Sensor for Glucose Detection in Saliva
Authors: Borràs‐Brull Marta , Blondeau Pascal , Riu Jordi 
Published: September 2020

AbstractA paper‐based potentiometric sensor was constructed and characterized for the detection of glucose in saliva. Dilution of the samples was optimized to afford the optimum experimental conditions of measurements. The performance allows for detecting abnormal high glucose concentrations observed in diabetes patients. Repeatability data were presented and the performance of the sensor compared to literature examples showing suitable characteristics at a much lower cost. The validation in real saliva samples was performed against a commercial colorimetric kit showing that glucose could be effectively determined in the 4–10 mM range based on the comparison with a reference method.
Transoral robotic parapharyngeal approach to the submandibular space
Authors: Floros Peter , Sorrentino Mariano , Magnuson J. Scott 
Published: September 2020

AbstractThe aim of the study was to demonstrate a novel transoral parapharyngeal approach to the submandibular space. The method used was the clinical case of a patient presenting with an anteriorly based tumor in the left submandibular space. The video shows the transoral robotic technique for access to the submandibular space through the parapharyngeal space for removal of the tumor. This approach allows for high definition visibility and complete access to structures in the submandibular space including the submandibular gland. For robotic head and neck surgeons performing lateral oropharyngectomies, the anatomy is familiar, and the technique avoids potential access issues with traditional floor of mouth incisions. Furthermore, it provides a novel technique for identification of the hypoglossal nerve for potential preservation in oropharyngeal malignancy. The transoral robotic parapharyngeal approach to the submandibular space is safe, reproducible, and avoids unnecessary cervical incisions.
New boundaries and dissociation of the mouse hippocampus along the dorsal‐ventral axis based on glutamatergic, GABAergic and catecholaminergic receptor densities
Authors: Lothmann Kimberley , Deitersen Jana , Zilles Karl , Amunts Katrin , Herold Christina 
Published: September 2020

AbstractIn rodents, gene‐expression, neuronal tuning, connectivity and neurogenesis studies have postulated that the dorsal, the intermediate and the ventral hippocampal formation (HF) are distinct entities. These findings are underpinned by behavioral studies showing a dissociable role of dorsal and ventral HF in learning, memory, stress and emotional processing. However, up to now, the molecular basis of such differences in relation to discrete boundaries is largely unknown. Therefore, we analyzed binding site densities for glutamatergic AMPA, NMDA, kainate and mGluR2/3, GABAergic GABAA (including benzodiazepine binding sites), GABAB, dopaminergic D1/5 and noradrenergic α1 and α2 receptors as key modulators for signal transmission in hippocampal functions, using quantitative in vitro receptor autoradiography along the dorsal‐ventral axis of the mouse HF. Beside general different receptor profiles of the dentate gyrus (DG) and Cornu Ammonis fields (CA1, CA2, CA3, CA4/hilus), we detected substantial differences between dorsal, intermediate and ventral subdivisions and individual layers for all investigated receptor types, except GABAB. For example, striking higher densities of α2 receptors were detected in the ventral DG, while the dorsal DG possesses higher numbers of kainate, NMDA, GABAA and D1/5 receptors. CA1 dorsal and intermediate subdivisions showed higher AMPA, NMDA, mGluR2/3, GABAA, D1/5 receptors, while kainate receptors are higher expressed in ventral CA1, and noradrenergic α1 and α2 receptors in the intermediate region of CA1. CA2 dorsal was distinguished by higher kainate, α1 and α2 receptors in the intermediate region, while CA3 showed a more complex dissociation. Our findings resulted not only in a clear segmentation of the mouse hippocampus along the dorsal‐ventral axis, but also provides insights into the neurochemical basis and likely associated physiological processes in hippocampal functions. Therein, the presented data has a high impact for future studies modeling and investigating dorsal, intermediate and ventral hippocampal dysfunction in relation to neurodegenerative diseases or psychiatric disorders.
Does the use of alternative predictor methods reduce subgroup differences? It depends on the construct
Authors: Arthur Winfred , Keiser Nathanael L. , Atoba Olabisi A. , Cho Inchul , Edwards Bryan D. 
Published: September 2020

AbstractUsing a bare‐bones meta‐analysis, the present study examined the effectiveness of the use of commonly considered alternative predictor methods as a means to reduce subgroup differences (i.e., the method‐change approach), taking into account the constructs assessed. With a focus on assessment centers, interviews, situational judgment tests, and work samples as alternative methods, the results indicated that consonant with the construct/method distinction, the effectiveness of a method in reducing subgroup differences is a function of the constructs assessed. Specifically, there are larger White‐African American subgroup differences that favor Whites for cognitive constructs on paper‐and‐pencil tests compared to the alternative methods; and most notably, the opposite result was obtained for noncognitive constructs such that, compared to paper‐and‐pencil assessments, substantially larger White‐African American subgroup differences were observed for alternative methods. A similar pattern of results was obtained for White‐Hispanic comparisons, albeit based on a smaller number of data points. In summary, the study's results indicate that the ubiquitously asserted effectiveness of the method‐change approach for reducing subgroup differences is overstated, with said effectiveness depending on the construct assessed.
A concerted research effort to advance the hydrological understanding of tropical páramos
Authors: Correa Alicia , Ochoa‐Tocachi Boris F , Birkel Christian , Ochoa‐Sánchez Ana , Zogheib Charles , Tovar Carolina , Buytaert Wouter 
Published: September 2020

AbstractPáramos, a neotropical alpine grassland‐peatland biome of the northern Andes and Central America, play an essential role in regional and global cycles of water, carbon, and nutrients. They act as water towers, delivering water and ecosystem services from the high mountains down to the Pacific, Caribbean, and Amazon regions. Páramos are also widely recognized as a biodiversity and climate change hot spots, yet they are threatened by anthropogenic activities and environmental changes. Despite their importance for water security and carbon storage, and their vulnerability to human activities, only three decades ago, páramos were severely understudied. Increasing awareness of the need for hydrological evidence to guide sustainable management of páramos prompted action for generating data and for filling long‐standing knowledge gaps. This has led to a remarkably successful increase in scientific knowledge, induced by a strong interaction between the scientific, policy, and (local) management communities. A combination of well‐established and innovative approaches has been applied to data collection, processing, and analysis. In this review, we provide a short overview of the historical development of research and state of knowledge of the hydrometeorology, flux dynamics, anthropogenic impacts, and the influence of extreme events in páramos. We then present emerging technologies for hydrology and water resources research and management applied to páramos. We discuss how converging science and policy efforts have leveraged traditional and new observational techniques to generate an evidence base that can support the sustainable management of páramos. We conclude that this co‐evolution of science and policy was able to successfully cover different spatial and temporal scales. Lastly, we outline future research directions to showcase how sustainable long‐term data collection can foster the responsible conservation of páramos water towers.