bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross‐Domain Trajectories of Students’ Ability Self‐Concepts and Intrinsic Values in Math and Language Arts
Authors: Gaspard Hanna , Lauermann Fani , Rose Norman , Wigfield Allan , Eccles Jacquelynne S. 
Published: November 2019

Different cross‐domain trajectories in the development of students’ ability self‐concepts (ASCs) and their intrinsic valuing of math and language arts were examined in a cross‐sequential study spanning Grades 1 through 12 (n = 1,069). Growth mixture modeling analyses identified a Moderate Math Decline/Stable High Language Arts class and a Moderate Math Decline/Strong Language Arts Decline class for students’ ASC trajectories. Students’ intrinsic value trajectories included a Strong Math Decline/Language Arts Decline Leveling Off, a Moderate Math Decline/Strong Language Arts Decline, and a Stable Math and Language Arts Trajectories class. These classes differed with regard to student characteristics, including gender, family background, and math and reading aptitudes. They also resulted in different high school math course enrollments, career aspirations, and adult careers.
IL-1-dependent electrophysiological changes and cardiac neural remodeling in a mouse model of Kawasaki disease vasculitis
Authors: Abe M , Rastelli D D , Gomez A C , Cingolani E , Lee Y , Soni P R , Fishbein M C , Lehman T J A , Shimada K , Crother T R , Chen S , Noval Rivas M , Arditi M 
Published: November 2019

Summary
Kawasaki disease (KD) is the leading cause of acquired heart disease in children. In addition to coronary artery abnormalities, aneurysms and myocarditis, acute KD is also associated with echocardiogram (ECG) abnormalities in 40–80% of patients. Here, we show that these ECG changes are recapitulated in the Lactobacillus casei cell wall extract (LCWE)-induced KD vasculitis mouse model. LCWE-injected mice developed elevated heart rate and decreased R wave amplitude, with significant differences in prolonged ventricular repolarization. LCWE-injected mice developed cardiac ganglion inflammation, that may affect the impulse-conducting system in the myocardium. Furthermore, serum nerve growth factor (NGF) was significantly elevated in LCWE-injected mice, similar to children with KD vasculitis, associated with increased neural remodeling of the myocardium. ECG abnormalities were prevented by blocking interleukin (IL)-1 signaling with anakinra, and the increase in serum NGF and cardiac neural remodeling were similarly blocked in Il1r1−/− mice and in wild-type mice treated with anakinra. Thus, similar to clinical KD, the LCWE-induced KD vasculitis mouse model also exhibits electrophysiological abnormalities and cardiac neuronal remodeling, and these changes can be prevented by blocking IL-1 signaling. These data support the acceleration of anti-IL-1 therapy trials to benefit KD patients.
Integrated analysis of COL2A1 variant data and classification of type II collagenopathies
Authors: Zhang Boyan , Zhang Yue , Wu Naichao , Li Jianing , Liu He , Wang Jincheng 
Published: November 2019

AbstractThe COL2A1 gene encodes the alpha‐1 chain of type II procollagen. Type II collagen, comprised of three identical alpha‐1 chains, is the major component of cartilage. COL2A1 gene variants are the etiologies of genetic diseases, termed type II collagenopathies, with a wide spectrum of clinical presentations. To date, at least 460 distinct COL2A1 mutations, identified in 663 independent probands, and 21 definite disorders have been reported. Nevertheless, a well‐defined genotype‐phenotype correlation has not been established, and few hot spots of mutation have been reported. In this study, we analyzed data of COL2A1 variants and clinical information of patients obtained from the Leiden Open Variation Database 3.0, as well as the currently available relevant literature. We determined the characteristics of the COL2A1 variants and distributions of the clinical manifestations in patients, and identified four likely genotype‐phenotype correlations. Moreover, we classified 21 COL2A1‐related disorders into five categories, which may assist clinicians in understanding the essence of these complex phenotypes and prompt genetic screening in clinical practice.
Becoming Favela: Forced Resettlement and Reverse Transitions of Urban Space in Brazil
Authors: Kolling Marie 
Published: November 2019

AbstractThis article examines the forced resettlement offavelaresidents to a new neighborhood and the life they tried to make for themselves in the new state‐built social housing. They experienced a sense of betrayal by their new neighbors and by the state; much of what they had been promised was not delivered, and in the aftermath of resettlement they were left by the state project to their own devices. In the new neighborhood, the “territorial stigma” (Wacquant 2008) of the favela lingered on, placing the newcomers at the bottom of the local social hierarchy in the impoverished periphery of the city. While battling this stigma, they were also pursuing their dreams for a better future by investing their scarce resources into the improvement of their new but poorly built homes. Their house‐building practices resemble the urban development processes of “peripheral urbanization” (Caldeira 2016), as the slow and uneven self‐built constructions encroach on the ordered state‐built housing. The gradual transition of the new urban space followed a similar development pattern as the favela where they used to live, but in a reverse order, producing an inverse transition of urban space. I treat the negligence of the state, the housing practices of the residents, and the discursive practices of labeling the social housing a favela—by the long‐term neighbors and eventually the residents themselves—as co‐constituting an urban form, lived experience, and socio‐spatial process in which the housing project becomes favela. This analysis provides new insights into the anthropological literature on urban development and illicit house‐building in peripheral neighborhoods in the Global South and the socio‐spatial dynamics of forced resettlement.
DUETS (Dallas UtErus Transplant Study): Complete report of 6‐month and initial 2‐year outcomes following open donor hysterectomy
Authors: Ramani Azaan , Testa Giuliano , Ghouri Yumna , Koon Eric C. , Di Salvo Marco , McKenna Greg J. , Bayer Johanna , Marie Warren Ann , Wall Anji , Johannesson Liza 
Published: November 2019

AbstractIntroductionUterus transplantation has shown success in treating women with uterine factor infertility who want to carry their own pregnancy.MethodsWe report the medical, sexual, and psychological outcomes of our first cohort of 13 living donor hysterectomies. As we have transitioned from open to robotically assisted hysterectomy, this report represents the complete series of open donor hysterectomies at our center, all with ≥6‐month postoperative outcomes.ResultsThe open donor hysterectomy had a median of a 6.5‐hour surgical time, 0.8 L estimated blood loss, 6‐day hospital stay, and 28‐day sick leave. Three donors had a grade III or IV complications, one reported new‐onset psychological symptoms, and 9 experienced transient sexual discomfort. All complications were addressed and resolved, and all donors returned to their presurgical social and physical activities.ConclusionSince uterus transplantation is not life‐saving or life‐extending, the risks in living uterus donation must be weighed against the benefit of giving another woman the opportunity to give birth to her own child. This report provides data to support more detailed informed consent regarding the medical, psychological, and sexual complications of open living donor hysterectomy and allows for further evaluation of the ethical acceptability of this procedure.
Hanging donor lungs give good short‐, mid‐ and long‐term results in lung transplantation
Authors: De Wolf Julien , Renard Regis , Lehouerou Thomas , Glorion Matthieu , Pricopi Ciprian , Bonnette Pierre , Parquin Francois , Roux Antoine , Leguen Morgan , Chapelier Alain , Sage Edouard 
Published: November 2019

AbstractBackgroundHanging donors are considered as marginal donors and frequently unsuitable for lung transplantation. However, there is no evidence of higher lung transplantation (LTx) morbidity‐mortality with lungs providing by hanging donor.MethodsBetween January 2010 and July 2015, we performed a retrospective study at Foch hospital. We aimed to assess whether hanging donor grafts are suitable for lung transplantation.ResultsA total of 299 LTx were performed. Subjects were allocated to a hanging group (HG) (n = 20) and a control group (CG) (n = 279). Donor and recipient characteristics did not differ. Primary graft dysfunction (PGD) at 72 hours was comparable in both groups (P = .75). The median duration of postoperative mechanical ventilation (1 [range, 0‐84] vs 1 [range, 0‐410] day, P = .35), the hospital length of stay (31 days [20‐84] vs 32 days [12‐435], P = .36) did not differ between the two groups. No statistically significant difference was found in 1‐year and 5‐year survival between the HG (83% and 78%) and the CG (86% and 75%), P = .85.ConclusionWe believe that hanging donors should be considered as conventional donors with particular caution in the final evaluation of the graft and in perioperative management.
Clinical Utility of Pharmacogene Panel‐Based Testing in Patients Undergoing Percutaneous Coronary Intervention
Authors: El Rouby Nihal , Alrwisan Adel , Langaee Taimour , Lipori Gloria , Angiolillo Dominick J , Franchi Francesco , Riva Alberto , Elsey Amanda , Johnson Julie A. , Cavallari Larisa H. , Winterstein Almut G. 
Published: November 2019

We aimed to estimate the utility of panel‐based pharmacogenetic testing of patients undergoing percutaneous coronary intervention (PCI). Utilization of Clinical Pharmacogenetic Implementation Consortium (CPIC) level A/B drugs after PCI was estimated in a national sample of IBM MarketScan beneficiaries. Genotype data from University of Florida (UF) patients (n = 211) who underwent PCI were used to project genotype‐guided opportunities among MarketScan beneficiaries with at least one (N = 105,547) and five (N = 12,462) years of follow‐up data. The actual incidence of genotype‐guided prescribing opportunities was determined among UF patients. In MarketScan, 50.0% (52,799/105,547) over 1 year and 68.0% (8,473/12,462) over 5 years had ≥ 1 CPIC A/B drug besides antiplatelet therapy prescribed, with a projected incidence of genotype‐guided prescribing opportunities of 39% at 1 year and 52% at 5 years. Genotype‐guided prescribing opportunities occurred in 32% of UF patients. Projected and actual incidence of genotype‐guided opportunities among two cohorts supports the utility of panel‐based testing among patients who underwent PCI.
Making Better Dose Decisions: Using Exposure‐Response Modeling to Integrate Efficacy Outcome of Two Phase IIb Clinical Trials of Ubrogepant for Migraine Treatment
Authors: Li Chi‐Chung , Voss Tiffini , Kowalski Ken , Yang Bei , Kleijn Huub Jan , Jones Christopher J. , Bosch Rolien , Michelson David , DeAngelis Matthew , Xu Yang , Xie Iris , Kothare Prajakti A. 
Published: November 2019

Ubrogepant (MK‐1602) is a novel, oral, calcitonin gene‐related peptide receptor antagonist in clinical development with positive phase III outcomes for acute treatment of migraine. This paper describes the population exposure‐response (E‐R) modeling and simulations, which were used to inform the phase III dose‐selection rationale, based on ~ 800 participants pooled across two phase IIb randomized dose‐finding clinical trials. The E‐R model describes the placebo and ubrogepant treatment effects based on migraine pain end points (2‐hour pain relief and 2‐hour pain freedom) at various dose levels. Sensitivity analyses were conducted to evaluate various assumptions of placebo response in light of the high placebo response observed in one phase II trial. A population pharmacokinetic model describing the effect of formulations was included in the E‐R simulation framework to assess potential dose implications of a formulation switch from phase II to phase III. Model‐based simulations predict that a dose of 25 mg or higher is likely to achieve significantly better efficacy than placebo with desirable efficacy levels. The understanding of E‐R helped support the dose selection for the phase III clinical trials.
Childhood abuse as a risk factor for injection drug use: A systematic review of observational studies
Authors: Prangnell Amy , Imtiaz Sameer , Karamouzian Mohammad , Hayashi Kanna 
Published: November 2019

AbstractIssuesChildhood abuse is a public health challenge with lifelong impacts, including future drug use. However, previous research has been mixed regarding impacts on injection drug use. This systematic review examines the impact of childhood abuse (sexual, physical and emotional) on adult injection drug use.ApproachWe searched MEDLINE, EMBASE, PsycINFO, CINAHL, Web of Science and grey literature to identify relevant studies from database inception to 26 September 2018. Studies were eligible if: (i) they were empirical original research published in English; (ii) considered childhood abuse as potential risk factors for lifetime history of injection drug use; and (iii) included adult participants. Risk of bias was assessed using the modified Newcastle‐Ottawa Scale.Key FindingsOf the 1994 articles screened, 17 studies met the inclusion criteria. Most studies were conducted in the USA and utilised cross‐sectional research designs. All of the 17 studies measured sexual abuse, six studies measured physical abuse and three studies measured emotional abuse; most (N = 11) of which reported a statistically significant and positive association between at least one sub‐scale of childhood abuse and injection drug use.ImplicationsOur findings highlight the need for devising interventions to reduce the harms associated with childhood abuse.ConclusionsThe evidence base suggests a significant positive association between experiences of childhood physical abuse and elevated risks of injection drug initiation with mixed results for sexual and emotional abuse.
Multimodality imaging of an aortic graft infection
Authors: Uslu Abdulkadir , Kup Ayhan , Güner Ahmet , Çelik Mehmet , Kahyaoglu Muzaffer , Güner Ezgi Gültekin , Uzun Fatih , Kahveci Gökhan 
Published: November 2019

AbstractAortic prosthetic vascular graft infections (PVGI) are rare complications of the aortic surgery, with an incidence of 0.5%‐6%. Although rare, they carry mortality rates as high as 25%‐88%. Improvement in diagnostic imaging modalities in the last two decades, together with early diagnosis, aortic PVGI associated mortality was reduced. These imaging methods include transesophageal echocardiography (TEE), computed tomography angiography (CTA), and 18F‐fluorodeoxyglucose positron emission tomography/computed tomography (18F‐FDG PET/CT). In this case report, we focus mainly on three imaging modalities as TEE, CTA, and 18F‐FDG PET/CT and showed their role in the assessment of aortic PVGI.
Violent outcomes in first‐episode psychosis: A clinical cohort study
Authors: Whiting Daniel , Lennox Belinda R. , Fazel Seena 
Published: November 2019

AbstractAimViolence risk is an important part of a comprehensive clinical assessment in first‐episode psychosis. This study addresses limitations of previous violent outcome research in first‐episode psychosis, which has typically investigated selected cohorts or been restricted to violence occurring prior to service contact, with limited use of police data.MethodsFor individuals consecutively assessed by Early Intervention in Psychosis (EIP) services in two UK regions (n = 177), violent outcomes in the subsequent 12‐months were collected using electronic patient records, supplemented by police data.ResultsOf individuals accepted by EIP services (n = 109), electronic medical records indicated around 1 in 4 (n = 28, 25.7%) perpetrated any physical violence, and 1 in 10 (n = 10, 9.2%) were arrested or charged for violent offences in the 12‐months after first contact. Police data on all individuals assessed (n = 177) reported 1 in 7 (n = 26, 14.7%) were arrested or charged for violent offences in the 12‐months after first contact.ConclusionsEIP services should consider integrating multi‐agency sources of data to evaluate violent outcomes. The potential role of violence risk management should be further examined.
Efficacy of a brief mindfulness intervention upon anxiety in early psychosis patients
Authors: Ernst Alycia F. , D'Mello Dale 
Published: November 2019

AbstractAimTo examine the efficacy of a brief mindfulness intervention in reducing anxiety in early psychosis patients, and to determine whether symptom burden mitigates therapeutic response.MethodsOur study included patients who had experienced an initial episode of psychosis, with less than 30 months of antipsychotic exposure. First, the prescriber completed the COMPASS Clinician Rating Form (measuring symptom burden), and patients completed the POMS questionnaire (measuring anxiety). A 3‐minute mindfulness exercise was administered, and patients again completed the POMS scale. The differences between the pre‐ and postintervention anxiety scores were analysed using a paired t test.ResultsA total of 20 subjects participated. The mean Anxiety Subscale of the POMS scores decreased from 4.6 to 1.7. The change was statistically significant, and not influenced by symptom burden.ConclusionsA brief mindfulness exercise, conducted in a routine office visit, produced a significant reduction in state anxiety for early psychosis patients, regardless of symptom burden.
Inhibition of PLK1 by capped‐dose volasertib exerts substantial efficacy in MDS and sAML while sparing healthy haematopoiesis
Authors: Dill Veronika , Kauschinger Johanna , Hauch Richard T. , Buschhorn Lars , Odinius Timo O. , Müller‐Thomas Catharina , Mishra Ritu , Kyncl Michele C. , Schmidt Burkhard , Prodinger Peter M. , Hempel Dirk , Bellos Frauke , Höllein Alexander , Kern Wolfgang , Haferlach Torsten , Slotta‐Huspenina Julia , Bassermann Florian , Peschel Christian , Götze Katharina S. , Waizenegger Irene C. , Höckendorf Ulrike , Jost Philipp J. , Jilg Stefanie 
Published: November 2019

AbstractIntroductionTargeting the cell cycle machinery represents a rational therapeutic approach in myelodysplastic syndromes (MDS) and secondary acute myeloid leukemia (sAML). Despite substantial response rates, clinical use of the PLK inhibitor volasertib has been hampered by elevated side effects such as neutropenia and infections.ObjectivesThe primary objective was to analyse whether a reduced dose of volasertib was able to limit toxic effects on the healthy haematopoiesis while retaining its therapeutic effect.MethodsBone marrow mononuclear cells (BMMNCs) of patients with MDS/sAML (n = 73) and healthy controls (n = 28) were treated with volasertib (1 μM to 1 nM) or vehicle control. Short‐term viability analysis was performed by flow cytometry after 72 hours. For long‐term viability analysis, colony‐forming capacity was assessed after 14 days. Protein expression of RIPK3 and MCL‐1 was quantified via flow cytometry.ResultsReduced dose levels of volasertib retained high cell death‐inducing efficacy in primary human stem and progenitor cells of MDS/sAML patients without affecting healthy haematopoiesis in vitro. Interestingly, volasertib reduced colony‐forming capacity and cell survival independent of clinical stage or mutational status.ConclusionsVolasertib offers a promising therapeutic approach in patients with adverse prognostic profile. RIPK3 and MCL‐1 might be potential biomarkers for sensitivity to volasertib treatment.
Spinning strands into aspects: Realism, idealism, and finite modes in Spinoza
Authors: Shein Noa 
Published: November 2019

AbstractThere is a long tradition of reading Spinoza as committed, perhaps unwillingly, to the non‐reality of finite modes. While acknowledging that Spinoza does seem to rely on the reality of modes in certain places, Michael Della Rocca has called attention to what he labels an “idealist strand.” As a concluding remark in “Steps Toward Eleaticism in Spinoza's Philosophy of Action,” he claims that faced with these two conflicting strands, which are genuinely to be found in the text, it is better to note both rather than artificially imposing a unity on the text. In this paper, I suggest that one need not admit two conflicting strands in Spinoza, on the one hand, nor arbitrarily disregard one strand, on the other. Rather, I argue for a unified view that diagnoses what gives rise to both seemingly conflicting strands. The key to this enterprise is recognizing that finite modes, paradoxically seeming perhaps at first, are not wholly finite. That is, a finite mode is determined by the totality of finite modes—wherein lies its finite aspect, but at the same time, and equally, partially actively determines this totality—wherein lies its infinite aspect.
Ecological effects of non‐native species in marine ecosystems relate to co‐occurring anthropogenic pressures
Authors: Geraldi Nathan R. , Anton Andrea , Santana‐Garcon Julia , Bennett Scott , Marbà Nuria , Lovelock Catherine E. , Apostolaki Eugenia T. , Cebrian Just , Krause‐Jensen Dorte , Martinetto Paulina , Pandolfi John M. , Duarte Carlos M. 
Published: November 2019

AbstractPredictors for the ecological effects of non‐native species are lacking, even though such knowledge is fundamental to manage non‐native species and mitigate their impacts. Current theories suggest that the ecological effects of non‐native species may be related to other concomitant anthropogenic stressors, but this has not been tested at a global scale. We combine an exhaustive meta‐analysis of the ecological effects of marine non‐native species with human footprint proxies to determine whether the ecological changes due to non‐native species are modulated by co‐occurring anthropogenic impacts. We found that non‐native species had greater negative effects on native biodiversity where human population was high and caused reductions in individual performance where cumulative human impacts were large. On this basis we identified several marine ecoregions where non‐native species may have the greatest ecological effects, including areas in the Mediterranean Sea and along the northwest coast of the United States. In conclusion, our global assessment suggests coexisting anthropogenic impacts can intensify the ecological effects of non‐native species.