bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brand engagement in self-concept (BESC), value consciousness and brand loyalty: a study of generation Z consumers in Malaysia
Authors: Ismail Ahmed Rageh , Nguyen Bang , Chen Junsong , Melewar T.C. , Mohamad Bahtiar 
Published: March 2020

Purpose
This study aims to examine the relationship between brand engagement in self-concept (BESC), value consciousness (VC) and brand loyalty among Generation Z consumers. In addition, the study aims to segment the Generation Z consumers based on BESC and VC and examine the differences between the segments.

Design/methodology/approach
A self-administered questionnaire was developed and administered to a sample of 346 undergraduate students in Malaysia. The hypothesized structural models are tested using partial least squares structural equation modeling. The study also uses cluster analysis to segment the Generation Z consumers.

Findings
The results reveal that among Generation Z consumers both BESC and VC have a positive effect on brand loyalty. Additionally, the mediation analysis established that BESC plays a mediating role in the relationship between VC and brand loyalty. The study also identified four consumer groups – attentive group, dedicated group, prospective group and switchers group. Furthermore, consumer classification according to BESC can be used by marketers and managers in marketing strategy development.

Originality/value
The study has originality and value in developing and testing a new model linking BESC with VC and brand loyalty. Further, market segmentation on the basis of BESC and VC has been rarely studied. Even less, has been studied among Generation Z consumers and this study fills this important gap.
Expression of small RNAs of Bordetella pertussis colonizing murine tracheas
Authors: Hiramatsu Yukihiro , Suzuki Koichiro , Motooka Daisuke , Nakamura Shota , Horiguchi Yasuhiko 
Published: March 2020

AbstractWe performed RNA sequencing on Bordetella pertussis, the causative agent of whooping cough, and identified nine novel small RNAs (sRNAs) that were transcribed during the bacterial colonization of murine tracheas. Among them, four sRNAs were more strongly expressed in vivo than in vitro. Moreover, the expression of eight sRNAs was not regulated by the BvgAS two‐component system, which is the master regulator for the expression of genes contributing to the bacterial infection. The present results suggest a BvgAS‐independent gene regulatory system involving the sRNAs that is active during B. pertussis infection.
Comparable space use by lions between hunting concessions and national parks in West Africa
Authors: Mills Kirby L. , Harissou Yahou , Gnoumou Isaac T. , Abdel‐Nasser Yaye I. , Doamba Benoit , Harris Nyeema C. 
Published: March 2020

Abstract

Spatially varied resources and threats govern the persistence of African lions across dynamic protected areas. An important precursor to effective conservation for lions requires assessing trade‐offs in space use due to heterogeneity in habitat, resources and human presence between national parks (NPs) and hunting areas, the dominant land‐use classifications across their range.

We conducted a large camera survey in West Africa, encompassing three NPs and 11 hunting concessions (HCs) in Burkina Faso and Niger. This equates to half of the 26,500‐km2 transboundary W‐Arly‐Pendjari protected area complex. We combined occupancy and structural equation modelling to disentangle the relative effects of environmental, ecological and anthropogenic variables influencing space use of Critically Endangered lions across 21,430 trap‐nights from 2016 to 2018.

National parks are intended to serve as refuges from human pressures, and thus we expect higher lion occupancy in NPs compared to neighbouring HCs. But because prey availability drove lion occupancy and was comparable between NPs and HCs, lions exhibited no spatial response to management type. Prey availability was primarily influenced by edge effects and natural water availability. Furthermore, water availability and habitat diversity were higher in HCs, possibly outweighing disturbances from higher human occupancy and road density and contributing to comparable lion space use between management types.

Synthesis and applications. We found that lions exhibited no avoidance hunting concessions, despite higher human occupancy than in neighbouring national parks. This may be due to the lions’ heavy reliance on depleted prey populations and preferred habitat characteristics in hunting concessions. We offer potential management interventions to indirectly influence lion space use, such as enhancing water availability and reducing human disturbance at park edges. Our findings provide insight into lion habitat preferences in a system degraded by human pressures and prey depletion, aiding in the understanding of the management's role in the ecology and conservation of apex predators and hunted species.
Predicting postmortem interval based on microbial community sequences and machine learning algorithms
Authors: Liu Ruina , Gu Yuexi , Shen Mingwang , Li Huan , Zhang Kai , Wang Qi , Wei Xin , Zhang Haohui , Wu Di , Yu Kai , Cai Wumin , Wang Gongji , Zhang Siruo , Sun Qinru , Huang Ping , Wang Zhenyuan 
Published: March 2020

SummaryMicrobes play an essential role in the decomposition process but were poorly understood in their succession and behaviour. Previous researches have shown that microbes show predictable behaviour that starts at death and changes during the decomposition process. Research of such behaviour enhances the understanding of decomposition and benefits estimating the postmortem interval (PMI) in forensic investigations, which is critical but faces multiple challenges. In this study, we combined microbial community characterization, microbiome sequencing from different organs (i.e. brain, heart and cecum) and machine learning algorithms [random forest (RF), support vector machine (SVM) and artificial neural network (ANN)] to investigate microbial succession pattern during corpse decomposition and estimate PMI in a mouse corpse system. Microbial communities exhibited significant differences between the death point and advanced decay stages. Enterococcus faecalis, Anaerosalibacter bizertensis, Lactobacillus reuteri, and so forth were identified as the most informative species in the decomposition process. Furthermore, the ANN model combined with the postmortem microbial data set from the cecum, which was the best combination among all candidates, yielded a mean absolute error of 1.5 ± 0.8 h within 24‐h decomposition and 14.5 ± 4.4 h within 15‐day decomposition. This integrated model can serve as a reliable and accurate technology in PMI estimation.
“Who generates this city”? Socialist strategy in contemporary London
Authors: Mukherjee Jacob 
Published: March 2020

AbstractThis essay, based on a “militant ethnography” of the attempts of the small radical grassroots activist group, Our London (a pseudonym), to mobilize a collective oppositional politics through activities around an election campaign, engages critically with E. Laclau and C. Mouffe's arguments on discourse and collectivity in Hegemony and Socialist Strategy (London: Verso, 1985). I argue, on the basis of my findings, that while their model does provide insights that help describe the process of building collectivity from among disparate perspectives and identities, we need to go beyond a focus on discourse alone and consider the ways politics is shaped by material contexts. This is necessary if we are to understand the continued appeal of class politics as well as the difficulties in mobilizing collectivity in highly unequal and fragmented cities. From an activist perspective, the essay also highlights how developing a conception of collective interests and a critique of overarching systems of exploitation can be important in building political unity.
Exosome‐derived uterine miR‐218 isolated from cows with endometritis regulates the release of cytokines and chemokines
Authors: Wang Xiangguo , Yao Xinxin , Xie Tongtong , Chang Zhenyu , Guo Yong , Ni Hemin 
Published: March 2020

SummaryAs an inflammation of the endometrium, endometritis can affect fertility and lead to serious economic losses in the dairy industry. Widely found in various tissues and body fluids, exosomes and exosome micro (mi)RNAs have been shown to play an important regulatory role in the immune responses. As one of differentially expressed exosome miRNAs, miR‐218 is involved in the pathogenesis of bovine endometritis. The mechanisms of miR‐218 in regulating the release of cytokines and chemokines in endometritis, however, are poorly understood. Exosomes were isolated from bovine uterine cavity fluid and verified by transmission electron microscopy. An in vitro lipopolysaccharide‐treated cell model for bovine endometritis was then established to evaluate the correlation between exosome‐derived miR‐218 and the immune responses. We demonstrated that exosomes could be used to deliver miR‐218 from endometrial epithelial cells (EECs) into the uterine microenvironment and adjacent recipient cells to modulate local immune responses. miR‐218 packaged in the exosomes secreted from EECs acts as an inhibitor by blocking immune factors such as interleukin (IL)‐6, IL‐1β, tumour necrosis factor‐α, the chemokines macrophage inflammatory genes (MIP)‐1α and MIP‐1β to maintain the immune balance in the uterus. However, uterine inflammation altered the immunoregulatory mechanism of exosome miR‐218. MiR‐218 is a potential biomarker for the detection of endometritis. Our findings also revealed a new mechanism for the development of endometritis in cows.
Letter: immunogenicity of infliximab—ready for routine prediction? Authors' reply
Authors: Wilson Aze , Peel Celeste , Wang Qian , Pananos A. Demetri , Kim Richard B. 
Published: March 2020

LINKED CONTENTThis article is linked to Wilson et al papers. To view these articles, visit https://doi.org/10.1111/apt.15563 and https://doi.org/10.1111/apt.15584.
Child maltreatment is linked to difficulties in identifying with social groups as a young adult
Authors: Sani Fabio , Herrera Marina , Bielawska Karolina 
Published: March 2020

Subjective feelings of disconnectedness from social groups have been found to be detrimental to mental health. However, little is known about the factors determining people’s ability to attach to groups. We contend that child maltreatment will impair people’s ability to group identification across the lifespan, and present a cross‐sectional study involving 396 young adults from Spain, aimed at testing this hypothesis. Results reveal that, as expected, a greater degree of maltreatment received before the age of 14 is linked to a lower number of social groups one identifies with, even after controlling for current levels of depression, anxiety, and borderline personality.
Statement of contribution

What is already known on this subject?

Experiencing a subjective sense of identification with groups promotes well‐being and psychological adjustment.

Subjective feelings of disconnectedness from social groups are detrimental to mental health.

What does this study add?

Little is known about the factors determining people’s ability to identify with groups. Child maltreatment is analysed as an important distal determinant of this ability.

Child maltreatment thwarts people’s ability to develop a sense of belonging to social groups.

A greater degree of maltreatment received before the age of 14 is linked to a lower number of social groups young adults identifies with, after controlling for core mental health dimensions.
Ternary complex formation of AFN‐1252 with Acinetobacter baumannii FabI and NADH: Crystallographic and biochemical studies
Authors: Rao Narasimha K , Nataraj Vijayashankar , Ravi Mohan , Panchariya Love , Palai Kirttija , Talapati Sumalatha R. , Lakshminarasimhan Anirudha , Ramachandra Murali , Antony Thomas 
Published: March 2020

AbstractAcinetobacter baumannii is an opportunistic Gram‐negative bacterial pathogen, associated mostly with hospital‐acquired infections. The emergence of drug resistance strains made it necessary to explore new pathways for the development of more effective antibiotics. Enoyl CoA reductase (FabI), a key enzyme in the fatty acid biosynthesis (FAS) pathway, has emerged as a potential target for antibacterial drug development. Earlier reports show that the lead SaFabI inhibitor AFN‐1252 can inhibit FabI from other organisms including Escherichia coli and Burkholderia pseudomallei, but with differential potency. In the present work, we show that AFN‐1252 is a moderate inhibitor of AbFabI with an IC50 of 216 nM. AFN‐1252 stabilized AbFabI with a 4.2°C increase in the melting temperature (Tm) and, interestingly, the stabilization effect was significantly increased in presence of the cofactor NADH (∆Tm = 17°C), suggesting the formation of a ternary complex AbFabI: AFN‐1252: NADH. X‐ray crystallography studies of AbFabI co‐crystalized with AFN‐1252 and NADH confirmed the ternary complex formation. The critical interactions of AFN‐1252 with AbFabI and NADH identified from the co‐crystal structure may facilitate the design and development of new drugs against A. baumannii infections by targeting the FAS pathway.
Children's perspectives on their economic activity—Diversity, motivations and parental awareness
Authors: Xolocotzin Ulises , Jay Tim 
Published: March 2020

AbstractThis research investigates how children from an affluent city in the UK exercise agency to construct their economic worlds. A survey (n = 484) showed that children (ages 10 to 14 years) conduct a range of monetary and non‐monetary activities. A second study (n = 83) with diaries, self‐documentation, and parental questionnaires, showed that children's economic activity involves individual and social motivations, occurs in formal and informal contexts, and is often self‐regulated. Parents acknowledge children's monetary activities and neglect non‐monetary activities. The results suggest that children's agency unfolds in diverse economic activities shaped by contextual factors and interactions with peers and parents, thereby supporting a relational view of children's agency.
Should China Join the New Trans‐Pacific Partnership?
Authors: Petri Peter A. , Plummer Michael G. 
Published: March 2020

AbstractAfter President Donald Trump's ill‐advised pullout from the Trans‐Pacific Partnership (TPP) and despite the absence of the US, the remaining 11 Asian and Pacific countries agreed on a deal, renamed the Comprehensive and Progressive Agreement for Trans‐Pacific Partnership (CPTPP). The accord took effect on 30 December 2018 and provides rigorous, up‐to‐date rules for Asia‐Pacific trade, but excludes the region's two biggest economies: the US and China. In this paper, we calculate that Chinese membership in the CPTPP would yield large economic and political benefits to China and other members. The CPTPP, in its current form, would generate global income gains estimated at US$147bn annually. If China were to join, these gains would quadruple to US$632bn, or a quarter more than in the original TPP with the US. But to join the CPTPP, China would have to undertake unprecedented reforms and manage complex political challenges.
Empagliflozin reduces the risk of mortality and hospitalization for heart failure across Thrombolysis In Myocardial Infarction Risk Score for Heart Failure in Diabetes categories: Post hoc analysis of the EMPA‐REG OUTCOME trial
Authors: Verma Subodh , Sharma Abhinav , Zinman Bernard , Ofstad Anne Pernille , Fitchett David , Brueckmann Martina , Wanner Christoph , Zwiener Isabella , George Jyothis T. , Inzucchi Silvio E. , Butler Javed , Mazer C. David 
Published: March 2020

AbstractAimTo investigate the association of the Thrombolysis In Myocardial Infarction (TIMI) Risk Score for Heart Failure in Diabetes (TRS‐HFDM) with mortality using data from the EMPA‐REG OUTCOME trial.Materials and MethodsIn EMPA‐REG OUTCOME, patients with type 2 diabetes and atherosclerotic cardiovascular (CV) disease (N = 7020) received the sodium‐glucose co‐transporter‐2 inhibitor, empagliflozin, 10 or 25 mg or placebo. Post hoc, patients were stratified into risk categories (low‐intermediate, high, very‐high risk scores) using baseline TRS‐HFDM. Cox regression analyses evaluated the association of TRS‐HFDM categories with all‐cause mortality (ACM), CV death, hospitalization for heart failure (HHF) and CV death (excluding fatal stroke) or HHF, and whether empagliflozin reduced the risk of CV outcomes across these risk categories.ResultsIn placebo patients, increasing risk category was associated with a higher risk of ACM, CV death, and HHF. Empagliflozin reduced the risk of ACM (low‐intermediate HR 0.68 [95% CI 0.48, 0.97] and very‐high 0.69 [0.52, 0.91]), CV death (0.75 [0.48, 1.18] and 0.56 [0.41, 0.78]), HHF (0.53 [0.28, 1.01] and 0.67 [0.48, 0.96]), and CV death or HHF (0.69 [0.46, 1.03]) and (0.64 [0.49, 0.82]) across all risk categories versus placebo. Higher absolute risk reductions (ARRs) were observed for CV death in the very‐high versus low‐intermediate category (P = 0.01).ConclusionsApplied to EMPA‐REG OUTCOME, higher TRS‐HFDM was associated with increased HHF and mortality risk. Empagliflozin reduced CV outcomes across TRS‐HFDM categories. Higher ARRs were associated with higher risk scores.
Semaglutide improves health‐related quality of life versus placebo when added to standard of care in patients with type 2 diabetes at high cardiovascular risk (SUSTAIN 6)
Authors: Jódar Esteban , Michelsen Marie , Polonsky William , Réa Rosangela , Sandberg Anna , Vilsbøll Tina , Warren Mark , Harring Signe , Ziegler Uwe , Bain Stephen 
Published: March 2020

AbstractAimTo assess what drives change in health‐related quality of life (HRQoL) in type 2 diabetes in the SUSTAIN 6 trial and identify potential mediators of the treatment effect of semaglutide on HRQoL scores.Materials and MethodsThe Short Form (SF)‐36v2® questionnaire [comprising physical component summary (PCS) and mental component summary (MCS)] was used to assess changes in HRQoL from baseline to week 104, by treatment, in a prespecified analysis. This post‐hoc analysis assessed change in PCS and MCS using the following factors as parameter/covariate, using descriptive statistics and linear regressions: major adverse cardiac events, hypoglycaemia, gastrointestinal adverse events, at least one episode of nausea, vomiting or diarrhoea, and change in glycated haemoglobin (HbA1c), body weight, blood pressure, heart rate and estimated glomerular filtration rate.ResultsMean change in overall PCS score was +1.0 with semaglutide versus +0.4 with placebo, and +0.5 versus −0.2 for MCS. The treatment effect of semaglutide versus placebo (unadjusted estimate) was 0.7 [(95% confidence interval 0.1, 1.2); P = 0.018] on PCS and this was reduced when adjusted for change in HbA1c [0.4 (−0.2, 1.0), P = .167] and body weight [0.3 (−0.3, 0.9), P = .314]. The unadjusted treatment effect on MCS [0.7 (−0.0, 1.5), P = .054] was only reduced when adjusted for change in HbA1c [0.3 (−0.4, 1.1), P = .397]. When adjusting for all other parameters separately, the estimated effect of semaglutide on PCS and MCS qualitatively did not change.ConclusionsSemaglutide improved HRQoL versus placebo; greater improvements with semaglutide versus placebo were possibly mediated, in part, by change in HbA1c and body weight.Clinicaltrials.gov: NCT01720446 (SUSTAIN 6).
Cognitive processing speed in multiple sclerosis clinical practice: association with patient‐reported outcomes, employment and magnetic resonance imaging metrics
Authors: Macaron G. , Baldassari L. E. , Nakamura K. , Rao S. M. , McGinley M. P. , Moss B. P. , Li H. , Miller D. M. , Jones S. E. , Bermel R. A. , Cohen J. A. , Ontaneda D. , Conway D. S. 
Published: March 2020

Background and purposeTo analyze the relationship between cognitive processing speed, patient‐reported outcome measures (PROMs), employment and magnetic resonance imaging (MRI) metrics in a large multiple sclerosis cohort.MethodsCross‐sectional clinical data, PROMs, employment and MRI studies within 90 days of completion of the Processing Speed Test (PST), a technology‐enabled adaptation of the Symbol Digit Modalities Test, were collected. MRI was analyzed using semi‐automated methods. Correlations of PST score with PROMs and MRI metrics were examined using Spearman’s rho. Wilcoxon rank sum testing compared MRI metrics across PST score quartiles and linear regression models identified predictors of PST performance. Effects of employment and depression were also investigated.ResultsIn 721 patients (mean age 47.6 ± 11.4 years), PST scores were significantly correlated with all MRI metrics, including cord atrophy and deep gray matter volumes. Linear regression demonstrated self‐reported physical disability, cognitive function, fatigue and social domains (adjusted R2 = 0.44, P < 0.001) as the strongest clinical predictors of PST score, whereas that of MRI variables included T2 lesion volume, whole‐brain fraction and cord atrophy (adjusted R2 = 0.42, P < 0.001). An inclusive model identified T2 lesion volume, whole‐brain fraction, self‐reported upper extremity function, cognition and social participation as the strongest predictors of PST score (adjusted R2 = 0.51, P < 0.001). There was significant effect modification by depression on the relationship between self‐reported cognition and PST performance. Employment status was associated with PST scores independent of age and physical disability.ConclusionThe PST score correlates with PROMs, MRI measures of focal and diffuse brain injury, and employment. The PST score is a feasible and meaningful measure for routine multiple sclerosis care.
Evolution of spatial structure patterns of city networks in the Yangtze River Economic Belt from the perspective of corporate pledge linkage
Authors: Jin Xingxing , Hu Guojian , Ding Hailong , Ye Shilin , Lu Yuqi , Lin Jinhuang 
Published: March 2020

AbstractThe pledge of stock rights is a method for measuring the external horizontal connections of enterprises, which is more suitable to represent the city network compared with the vertical connections of enterprises. Meanwhile, it is greatly significant to express the relationships of regional spaces. The paper characterizes and explores the evolution of urban spatial structure with complex network research methods to enrich the relevant works on city networks in the Yangtze River Economic Belt from 2011 to 2017. The results are as follows: First, from 2011 to 2017, the pledge of stock rights among cities was enhanced significantly, and the trend of the city networks' characteristics become strengthened and more complicated. Second, cities in the Yangtze River Delta have relatively high connection values, however, cities in the western area are holding peripheral positions within the city network. Third, due to the advantages of economic agglomeration and radiation, the provincial capital have become the core nodes in the city network. Fourth, Shanghai, Hangzhou, and Nanjing have dominant positions within city networks in the Yangtze River Economic Belt. Particularly, Shanghai, as one of the leading financial centers in China, has a growing influence on other cities and gradually evolved into a regional growth pole city and the first core city.