bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glutamic acid decarboxylase 67 haplodeficiency in mice: consequences of postweaning social isolation on behavior and changes in brain neurochemical systems
Authors: Nullmeier Sven , Elmers Christoph , D’Hanis Wolfgang , Sandhu Kiran Veer Kaur , Stork Oliver , Yanagawa Yuchio , Panther Patricia , Schwegler Herbert 
Published: June 2020

AbstractReductions of glutamate acid decarboxylase (GAD67) and subsequent GABA levels have been consistently observed in neuropsychiatric disorders like schizophrenia and depression, but it has remained unclear how GABAergic dysfunction contributes to different symptoms of the diseases. To address this issue, we investigated male mice haplodeficient for GAD67 (GAD67+/GFP mice), which showed a reduced social interaction, social dominance and increased immobility in the forced swim test. No differences were found in rotarod performance and sensorimotor gating. We also addressed potential effects of social deprivation, which is known, during early life, to affect GABAergic function and induces behavioral abnormalities similar to the symptoms found in psychiatric disorders. Indeed, social isolation of GAD67+/GFP mice provoked increased rearing activity in the social interaction test and hyperlocomotion on elevated plus maze. Since GABA closely interacts with the dopaminergic, serotonergic and cholinergic neurotransmitter systems, we investigated GAD67+/GFP and GAD67+/+ mice for morphological markers of the latter systems and found increased tyrosine hydroxylase (TH)-IR fiber densities in CA1 of dorsal hippocampus. By contrast, no differences in numbers and densities of TH-positive neurons of the midbrain dopamine regions, serotonin (5-HT) neurons of the raphe nuclei, or choline acetyltransferase (ChAT)-expressing neurons of basal forebrain and their respective terminal fields were observed. Our results indicate that GAD67 haplodeficiency impairs sociability and increases vulnerability to social stress, provokes depressive-like behavior and alters the catecholaminergic innervation in brain areas associated with schizophrenia. GAD67+/GFP mice may provide a useful model for studying the impact of GABAergic dysfunction as related to neuropsychiatric disorders.
Industrielle Energietechnik
Authors: Berger Gregor , Holzer Alexandra , Raupenstrauch Harald 
Published: June 2020

ZusammenfassungEnergieeffizienz, Prozessoptimierung und die damit einhergehende Ressourcenschonung sind in Hinblick auf ökonomische, ökologische und sozioökonomische Aspekte ein zentrales Thema der energieintensiven Industrie. Die Arbeitsgruppe „Industrielle Energietechnik“ am Lehrstuhl für Thermoprozesstechnik (TPT) beschäftigt sich in diesem Zusammenhang mit der Bewertung von Prozessen und Erarbeitung von technisch-wirtschaftlichen Maßnahmen mit dem Ziel einer Energieeffizienzsteigerung. Im Speziellen handelt es sich um die energetische Optimierung von thermischen Prozessen und Anlagen im Hochtemperaturbereich (z. B. Industrieöfen, Hochtemperaturreaktoren, etc.) und deren Einbindung in den Gesamtprozess.Neben der Bilanzierung von Energie- und Stoffströmen sowie der Bewertung der Energieeffizienz verfügt die Arbeitsgruppe über Kompetenzen im Bereich der Erfassung wichtiger Betriebsparameter in Prozessen. So wurden mittels geeigneter Ausstattungen in der Vergangenheit zahlreiche Temperaturerfassungen bis hin zu In-situ-Messungen durchgeführt.
Functional ecology of wild bees in cities: towards a better understanding of trait-urbanization relationships
Authors: Buchholz Sascha , Egerer Monika H. 
Published: June 2020

AbstractA functional ecological understanding of urban wild bee communities is of growing importance especially in regard to biodiversity conservation, ecosystem service maintenance and effective conservation programmes. In this paper, we review and summarize the published literature aiming to inform future research investigations in the growing field of wild bee functional ecology. Specifically, we: (1) review which functional trait-based analyses have been carried out on wild bees in cities thus far; (2) summarize which wild bee species traits have been considered; (3) evaluate any consistent wild bee trait–environment relationships (i.e. urbanization) across studies; and (4) synthesize findings and limitations to inform future research recommendations. We reviewed 48 studies based on a systematic Web of Knowledge search. We found consistent trait characteristics for ‘nesting type’, ‘diet’, ‘body size’, ‘sociality’ and ‘phenology’ across studies. More than one third of the studies were descriptive and the majority of studies were located in urban gardens in temperate Europe and North America, calling for more research from underrepresented geographic regions and from the entire spectrum of urban habitat types. Of these studies, only five analyzed functional diversity indices and three studies applied statistics to relate urban wild bee traits to urbanization factors. Future studies should consider trait-based statistics, and could incorporate functional trait-based ecological networks to examine network shifts across urbanization gradients. Our review suggests that we lack generalizable information about wild bee trait and urbanization relationships yet, making conservation recommendations challenging. Therefore, we propose more research that considers methodological recommendations to develop a comparable and comprehensive understanding of how urbanization affects the functional ecology of urban wild bees to link with specific urban conservation measures.
Star Clusters Near and Far
Authors: Adamo Angela , Zeidler Peter , Kruijssen J. M. Diederik , Chevance Mélanie , Gieles Mark , Calzetti Daniela , Charbonnel Corinne , Zinnecker Hans , Krause Martin G. H. 
Published: June 2020

AbstractStar clusters are fundamental units of stellar feedback and unique tracers of their host galactic properties. In this review, we will first focus on their constituents, i.e. detailed insight into their stellar populations and their surrounding ionised, warm, neutral, and molecular gas. We, then, move beyond the Local Group to review star cluster populations at various evolutionary stages, and in diverse galactic environmental conditions accessible in the local Universe. At high redshift, where conditions for cluster formation and evolution are more extreme, we are only able to observe the integrated light of a handful of objects that we believe will become globular clusters. We therefore discuss how numerical and analytical methods, informed by the observed properties of cluster populations in the local Universe, are used to develop sophisticated simulations potentially capable of disentangling the genetic map of galaxy formation and assembly that is carried by globular cluster populations.
Structural uncertainty through the lens of model building
Authors: Baldissera Pacchetti Marina 
Published: June 2020

AbstractAn important epistemic issue in climate modelling concerns structural uncertainty: uncertainty about whether the mathematical structure of a model accurately represents its target. How does structural uncertainty affect our knowledge and predictions about the climate? How can we identify sources of structural uncertainty? Can we manage the effect of structural uncertainty on our knowledge claims? These are some of the questions that an epistemology of structural uncertainty faces, and these questions are also important for climate scientists and policymakers. I develop three desiderata for an epistemological account of structural uncertainty. In my view, an account of structural uncertainty should (1) identify sources of structural uncertainty, (2) explain how these sources limit the applicability of a model, and (3) show how the severity of structural uncertainty depends on the questions that can be asked of a model. I argue that analyzing structural uncertainty by paying attention to the details of model building can satisfy these desiderata. I focus on parametrizations, which are representations of important processes occurring at scales that are not resolved by climate models. Parametrizations are often thought to be ad-hoc, but I show that some important parametrizations are theoretically justified by explicit or implicit scale separation assumptions. These assumptions can also be supported empirically. Analyzing these theoretical and empirical justificatory roles of the scale separation assumptions can provide insights into how parametrizations contribute to structural uncertainty. I conclude by sketching how my approach can satisfy the desiderata I set out at the beginning, highlighting its importance for policy-relevant scientific statements about the climate.
Clinical Practice Guidelines on Ordering Echocardiography before Hip Fracture Repair Perform Differently from One Another
Authors: Swart Eric , Adair Chris , Seymour Rachel B. , Karunakar Madhav A. 
Published: June 2020

Background Osteoporotic hip fractures typically occur in frail elderly patients with multiple comorbidities, and repair of the fracture within 48 h is recommended. Pre-operative evaluation sometimes involves transthoracic echocardiography (TTE) to screen for heart disease that would alter peri-operative management, yet TTE can delay surgery and is resource intensive. Evidence suggests that the use of clinical practice guidelines (CPGs) can improve care. It is unclear which guidelines are most useful in hip fracture patients. Questions/Purposes We sought to evaluate the performance of the five commonly used CPGs in determining which patients with acute fragility hip fracture require TTE and to identify common features among high-performing CPGs that could be incorporated into care pathways. Patients and Methods We performed a retrospective study of medical records taken from an institutional database of osteoporotic hip fracture patients to identify those who underwent pre-operative TTE. History and physical examination findings were recorded; listed indications for TTE were compared against those given in five commonly used CPGs: those from the American College of Cardiology/American Heart Association (ACC/AHA), the British Society of Echocardiography (BSE), the European Society of Cardiology and the European Society of Anaesthesiology(ESC/ESA), the Association of Anaesthetists of Great Britain and Ireland (AAGBI), and the Scottish Intercollegiate Guidelines Network (SIGN). We then calculated the performance (sensitivity and specificity) of the CPGs in identifying patients with TTE results that had the potential to change peri-operative management. Results We identified 100 patients who underwent pre-operative TTE. Among those, the patients met criteria for TTE 32 to 66% of the time, depending on the CPG used. In 14% of those receiving TTE, the test revealed new information with the potential to change management. The sensitivity of the CPGs ranged from 71% (ESC/ESA and AAGBI) to 100% (ACC/AHA and SIGN). The CPGs’ specificity ranged from 37% (BSE) to 74% (ESC/ESA). The more sensitive guidelines focused on a change in clinical status in patients with known disease or clinical concern regarding new-onset disease. Conclusions In patients requiring fixation of osteoporotic hip fractures, TTE can be useful for identifying pathologies that could directly change peri-operative management. Our data suggest that established CPGs can be safely used to identify which patients should undergo pre-operative TTE with low risk of missed pathology.
Managing anticoagulation in the COVID-19 era between lockdown and reopening phases
Authors: Poli Daniela , Tosetto Alberto , Palareti Gulatiero , Barcellona Doris , Ciampa Antonio , Grandone Elvira , Manotti Cesare , Moia Marco , Squizzato Alessandro , Toschi Vincenzo , Testa Sophie ,   On the behalf of Italian Federation of Anticoagulation Clinics (FCSA)
Published: June 2020

AbstractPatients on anticoagulant treatment are constantly increasing, with an estimated prevalence in Italy of 2% of the total population. The recent spreadout of the COVID-19 pandemic requires a re-organization of Anticoagulation Clinics to prevent person-to-person viral diffusion and continue to offer the highest possible quality of assistance to patients. In this paper, based on the Italian Federation of Anticoagulation Clinics statements, we offer some advice aimed at improving patient care during COVID-19 pandemic, with particular regard to the lockdown and reopening periods. We give practical guidance regarding the following points: (1) re-thinking the AC organization, (2) managing patients on anticoagulants when they become infected by the virus, (3) managing anticoagulation surveillance in non-infected patients during the lockdown period, and (4) organizing the activities during the reopening phases.
Influence of the fly ash fraction after grinding process on the hydrothermal synthesis efficiency of Na-A, Na-P1, Na-X and sodalite zeolite types
Authors: Kunecki Piotr , Panek Rafał , Wdowin Magdalena , Bień Tomasz , Franus Wojciech 
Published: June 2020

Abstract
The fly ashes (Class F and C) have been successfully used as the main substrates in the hydrothermal syntheses of Na-A, Na-P1, Na-X and sodalite zeolites. Both ashes and their derivatives after milling with magnetic field grinder were used. The paper investigates the effect of fly ash fraction size on the syntheses efficiency and physicochemical properties of the obtained zeolites. The starting material and obtained zeolites were subjected to physicochemical characteristics using X-ray diffraction, X-ray fluorescence, particle size analysis, and scanning electron microscopy methods. The paper showed a significant effect of the used fly ash fractions on the quantity, purity, quality and level of crystallinity of the zeolites phase obtained. The application of the grinding process prior to the syntheses of zeolites, with a relatively small financial outlay, significantly increases their application potential. Obtained zeolites are a promising material in the context of their use, inter alia, in environmental protection.

Graphic abstract
Hydrodynamics of core-collapse supernovae and their progenitors
Authors: Müller Bernhard 
Published: June 2020

AbstractMulti-dimensional fluid flow plays a paramount role in the explosions of massive stars as core-collapse supernovae. In recent years, three-dimensional (3D) simulations of these phenomena have matured significantly. Considerable progress has been made towards identifying the ingredients for shock revival by the neutrino-driven mechanism, and successful explosions have already been obtained in a number of self-consistent 3D models. These advances also bring new challenges, however. Prompted by a need for increased physical realism and meaningful model validation, supernova theory is now moving towards a more integrated view that connects multi-dimensional phenomena in the late convective burning stages prior to collapse, the explosion engine, and mixing instabilities in the supernova envelope. Here we review our current understanding of multi-D fluid flow in core-collapse supernovae and their progenitors. We start by outlining specific challenges faced by hydrodynamic simulations of core-collapse supernovae and of the late convective burning stages. We then discuss recent advances and open questions in theory and simulations.
What should be the goal of public policies?
Authors: DURAND MARTINE 
Published: June 2020

AbstractShould subjective wellbeing, as measured by life evaluation, be the sole criterion for policies? This article answers this question negatively based on three arguments. First, it is important to distinguish between people's life evaluations, their emotional experiences and their sense of purpose; each has different drivers and consequences, implying that no single measure can adequately subsume the others. Second, while subjective wellbeing provides information missed by more conventional measures, the reverse is also true. This implies that information on the intrinsic importance of other key wellbeing dimensions cannot be derived from just looking at their instrumental value in raising subjective wellbeing. Third, the ‘utilitarian calculus’ implicit in subjective wellbeing regressions shines little light on normative decisions such as the attention we should focus on the worst off or on future generations. In contrast to the ‘automatic pilot’ approach to policies advocated by Frijters et al., this article favours an approach based on dashboards of indicators used to inform all of the stages of the policy cycles, as recently implemented by several OECD countries.
Effects of climate change and human influence in the distribution and range overlap between two widely distributed avian scavengers
Authors: SÁENZ-JIMÉNEZ FAUSTO , ROJAS-SOTO OCTAVIO , PÉREZ-TORRES JAIRO , MARTÍNEZ-MEYER ENRIQUE , SHEPPARD JAMES K. 
Published: June 2020

SummaryClimate change can cause geographic displacement of the ecological niche of a species, so that similar species that previously did not coexist could begin to face new interactions. Such geographic displacement and increased competition can also be exacerbated by anthropic intervention. Until less than 100 years ago,Vultur gryphusandCoragyps atratusdid not coexist. Nowadays, possibly as a result of climate change, changes in the distributions of both species created areas where they are now sympatric. Through ecological niche modeling, we evaluated the possible effects that future scenarios of climate change and human influence would have on the distribution and sympatry between the two species. Our models predict that the current distribution ofV. gryphuswill be reduced between 18% and 24% by 2050 and between 21% and 32% by 2070. Additionally, they predict that the distribution ofC. atratuswill be reduced by 31–52% by the year 2050 and 15–60% by 2070. The two algorithms predict a reduction in the areas of sympatry. However, for the northern Andes the overlap between the two species will increase, reaching up to 70% in the year 2070. The distribution ofC. atratuswill move towards higher areas in the altitudinal gradient, and this will generate an increase in the current sympatry between both species. No clear trend was observed on the effect of human influences on the areas of overlap between the scenarios evaluated. The possible effects of climate change and anthropic intervention in future scenarios found in this study highlight the need to include these effects in future analyses and conservation programs ofV. gryphusand other threatened vultures.
Broadband microstrip antennas with Cantor set fractal slots for vehicular communications
Authors: Ez-Zaki Fatima , Belahrach Hassan , Ghammaz Abdelilah 
Published: June 2020

AbstractVehicle-to-everything communications (V2X), whose main objective is to improve security and efficiency, are provided by ad hoc vehicle networks that allow communication between vehicles. In the current study, a hexagonal microstrip patch antenna has been developed to cover the navigational frequencies, WiMAX at 3.7 GHz and DSRC/IEEE802.11p at 5.9 GHz to meet the demands of various vehicular applications. The antenna design is based on Cantor fractal slot, partial ground plane, and inset feed which is directly fed through the microstrip line. The proposed antenna shields the frequency band from 3.22 to 6.5 GHz with VSWR$\lt$2 within all the frequency bands. The presented antenna can resonate well in the 5.85–5.95 GHz band assigned for DSRC/IEEE802.11p and 3.7 GHz assigned for LTE/V2X. Simulated antenna gain varies from 3.06 to 5.25 dB within the operated frequency range providing an omnidirectional simulated radiation pattern in the most azimuth plane. To prove the validity of the simulation results, the chosen antenna structure has been fabricated and tested using a vector network analyzer MS2630. The measurement shows good results, which make the antenna suitable for wireless applications of interest.
The relationship between iron metabolism, stress hormones, and insulin resistance in gestational diabetes mellitus
Authors: Feng Yan , Feng Qi , Lv Yuping , Song Xinna , Qu Hongmei , Chen Yangyang 
Published: June 2020

Abstract
Aim
To analyze the relationship between iron metabolism index and stress hormones, insulin resistance, and oxidative stress in gestational diabetes mellitus (GDM).

Methods
From January to November 2019, 75 patients with GDM were selected as GDM group, according to age of 1:1; 75 normal pregnant women were selected as Control group. Blood glucose, insulin, stress hormones such as cortisol, norepinephrine (NE), and epinephrine (E), and iron metabolism index such as serum iron, serum ferritin (SF), and transferrin saturation (TS) were measured. Insulin resistance was evaluated by homeostasis model insulin resistance index (HOMA-IR). Multiple linear regression was used to analyze the relationship between iron metabolism index and stress hormones, insulin resistance, and oxidative stress.

Results
The levels of NE, E, serum iron, SF, and TS saturation in the GDM group were higher than Control group (t = 3.82, 2.75, 3.14, 6.12, and 3.90, P < 0.05, <0.05, <0.05, <0.01, <0.01); HOMA-IR was higher in the GDM group (t = 4.92, P < 0.01); malondialdehyde (MDA) was higher, while superoxide dismutase (SOD) was lower than Control group (t = 5.25, 4.98, both P < 0.01). Epinephrine, norepinephrine, cortisol, and serum ferritin were positively correlated (r = 0.21, 0.17, and 0.21); epinephrine, cortisol, and transferrin were positively correlated (r = 0.12, 0.31). There was a positive correlation between HOMA-IR and SF and TS (r = 0.34, 0.34). MDA was positively correlated with SF and TS (r = 0.24, 0.29); SOD was negatively related to SF and TS (r = −0.12, −0.17).

Conclusions
Iron metabolism index is related to insulin resistance in GDM women. The change in iron metabolism may be involved in the pathogenesis of gestational diabetes caused by stress- adaptive disorder.
Comparison of antibacterial effectiveness of three rotary file system with different geometry in infected root canals before and after instrumentation–a double-blinded randomized controlled clinical trial
Authors: Siddique Riluwan , Nivedhitha Malli Sureshbabu , Ranjan Manish , Jacob Benoy , Solete Pradeep 
Published: June 2020

Abstract
Introduction
To compare the antibacterial effectiveness of three rotary file systems i.e., ProTaper Next, ProTaper Gold and XP-endo Shaper in root canals of teeth with asymptomatic apical periodontitis by using the real-time polymerase chain reaction.

Materials and methods
Root canals from single or multi-rooted teeth (straight canals) with necrotic pulps and asymptomatic apical periodontitis were instrumented using either ProTaper Next (n = 20), ProTaper Gold (n = 20) and XP-endo Shaper (n = 20) under irrigation with 3% sodium hypochlorite. Samples obtained before and after instrumentation were subjected to DNA extraction, amplification and quantitation of total amount of bacteria by using the real-time polymerase chain reaction.

Results
Samples were taken before preparation (S1) were positive for presence of bacteria, with mean numbers of 9.94 × 107, 20.4 × 107 and 9.20 × 107 bacterial cells for the ProTaper Next, ProTaper Gold and XP-endo Shaper groups, respectively. After preparation (S2) with ProTaper Next, ProTaper Gold, and XP-endo Shaper, root canals still had bacteria with mean counts of 11.8 × 105, 87.2 × 105 and 4.52 × 105 bacterial cells, respectively. Both XP-endo Shaper (99.50%) and ProTaper Next (98.81%) were effective in reducing total bacterial count, and there was no statistically significant difference between them (P > 0.05). XP-endo Shaper succeeded in reducing total bacterial count than ProTaper Gold (95.72%) and there exists statistically significant difference between them (P < 0.05).

Conclusions
XP-endo Shaper was highly effective in reducing total bacterial count from root canals of teeth with asymptomatic apical periodontitis than ProTaper Gold. ProTaper Next also showed improved microbial reduction percentage as compared with ProTaper Gold.