bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of exhausted sugar beet pulp as raw material for lactic acid production
Authors: Díaz Ana Belén , González Claudia , Marzo Cristina , Caro Ildefonso , Blandino Ana 
Published: February 2020

AbstractBACKGROUNDExhausted sugar beet pulp pellets (ESBPP), a sugar industry by‐product generated after sugar extraction in the sugar production process, have been used as a raw material for lactic acid (LA) production via hydrolysis and fermentation by Lactobacillus casei. To design a more cost‐effective process, simultaneous saccharification and fermentation (SSF) of ESBPP is proposed in the present study. The effects of pH control, nutrient supplementation and solid addition in fed‐batch SSF on lactic acid production were investigated.RESULTSThe highest LA concentration (26.88 g L–1) was reached in fed‐batch SSF at a solid/liquid loading of 0.2 g mL–1, with pH control (by adding 30 g L–1 CaCO3 to the medium) and nutrient supplementation (by adding 20 mL of MRS medium per 100 mL of buffer). Under these conditions, a maximum productivity of 0.63 g L−1 h−1 was achieved, which is 2.7 times higher than that attained in the control experiment (SSF inoculated at time 0 h). However, a slightly lower LA yield was obtained, revealing the need of an increasing dose of enzymes at high solid loading SSF.CONCLUSIONAn efficient fed‐batch SSF strategy with pH control and MRS supplementation is described in the present study, attaining higher LA productivity compared to separate hydrolysis and fermentation and SSF. © 2020 Society of Chemical Industry
Pathomechanism of intervertebral disc degeneration
Authors: Oichi Takeshi , Taniguchi Yuki , Oshima Yasushi , Tanaka Sakae , Saito Taku 
Published: February 2020

AbstractIntervertebral disc degeneration (IDD) is the main contributor to low back pain, which is a leading cause of disability worldwide. Although substantial progress has been made in elucidating the molecular mechanisms of IDD, fundamental and long‐lasting treatments for IDD are still lacking. With increased understanding of the complex pathomechanism of IDD, alternative strategies for treating IDD can be discovered. A brief overview of the prevalence and epidemiologic risk factors of IDD is provided in this review, followed by the descriptions of anatomic, cellular, and molecular structure of the intervertebral disc as well as the molecular pathophysiology of IDD. Finally, the recent findings of intervertebral disc progenitors are reviewed and the future perspectives are discussed.
3D Printing in analytical sample preparation
Authors: Li Feng , Ceballos Melisa Rodas , Balavandy Sepideh Keshan , Fan Jingxi , Khataei Mohammad Mahdi , Yamini Yadollah , Maya Fernando 
Published: February 2020

AbstractIn the last 5 years, additive manufacturing (three‐dimensional printing) has emerged as a highly valuable technology to advance the field of analytical sample preparation. Three‐dimensional printing enabled the cost‐effective and rapid fabrication of devices for sample preparation, especially in flow‐based mode, opening new possibilities for the development of automated analytical methods. Recent advances involve membrane‐based three‐dimensional printed separation devices fabricated by print‐pause‐print and multi‐material three‐dimensional printing, or improved three‐dimensional printed holders for solid‐phase extraction containing sorbent bead packings, extraction disks, fibers, and magnetic particles. Other recent developments rely on the direct three‐dimensional printing of extraction sorbents, the functionalization of commercial three‐dimensional printable resins, or the coating of three‐dimensional printed devices with functional micro/nanomaterials. In addition, improved devices for liquid–liquid extraction such as extraction chambers, or phase separators are opening new possibilities for analytical method development combined with high‐performance liquid chromatography. The present review outlines the current state‐of‐the‐art of three‐dimensional printing in analytical sample preparation.
Methylcobalamin‐Loaded PLCL Conduits Facilitate the Peripheral Nerve Regeneration
Authors: Zhang Deteng , Yang Weichao , Wang Chunyang , Zheng Honghao , Liu Zhizhou , Chen Zhehan , Gao Changyou 
Published: February 2020

AbstractThe feasible fabrication of nerve guidance conduits (NGCs) with good biological performance is important for translation in clinics. In this study, poly(d,l‐lactide‐co‐caprolactone) (PLCL) films loaded with various amounts (wt; 5%, 15%, 25%) of methylcobalamin (MeCbl) are prepared, and are further rolled and sutured to obtain MeCbl‐loaded NGCs. The MeCbl can be released in a sustainable manner up to 21 days. The proliferation and elongation of Schwann cells, and the proliferation of Neuro2a cells are enhanced on these MeCbl‐loaded films. The MeCbl‐loaded NGCs are implanted into rats to induce the regeneration of 10 mm amputated sciatic nerve defects, showing the ability to facilitate the recovery of motor and sensory function, and to promote myelination in peripheral nerve regeneration. In particular, the 15% MeCbl‐loaded PLCL conduit exhibits the most satisfactory recovery of sciatic nerves in rats with the largest diameter and thickest myelinated fibers.
Fabrication and Characterization of Highly Oriented Composite Nanofibers with Excellent Mechanical Strength and Thermal Stability
Authors: Pu Yi , Yang Xue , Zhang Yifei , Li Lujian , Xie Yuze , He Bin , Yuan Ding , Ning Xin 
Published: February 2020

AbstractHere, highly‐oriented poly(m‐phenylene isophthalamide)/polyacrylonitrile multi‐walled carbon nanotube (PMIA/PAN‐MWCNT) composite nanofiber membranes with excellent mechanical strength and thermal stability are successfully produced using electrospinning. It is demonstrated that the cooperation of multi‐walled carbon nanotubes (MWCNT) and high‐speed rotating collection is beneficial to the acquisition of highly oriented fibers and effectively improves the mechanical strength of the membrane along the orientation direction. Specifically, the tensile stress of poly(m‐phenylene isophthalamide)/polyacrylonitrile (PMIA/PAN) membrane is enhanced significantly from 10.6 to 20.7 MPa, benefiting from the highly oriented alignment of the fibers as well as the reinforcing effect of MWCNTs on the fibers. Furthermore, the stressing process of single fiber and fiber aggregates is carefully simulated, and the influence of MWCNTs on the mechanical properties of PMIA/PAN‐MWCNT membranes is analyzed comprehensively, providing a meaningful auxiliary means for the study of mechanical properties. In addition, the composite nanofiber membrane has the advantages of both PMIA and PAN, possessing high temperature resistance, flame‐retardancy, and chemical stability, for an ideal high‐temperature material. In short, the as‐prepared PMIA/PAN‐MWCNT composite membrane with excellent comprehensive property emerges a promising application in many fields, especially in high‐tech.
Effects of the outer size on tropical cyclone track forecasts
Authors: Tang Chi Kit , Chan Johnny C. L. , Yamaguchi Munehiko 
Published: February 2020

AbstractThe track forecast of a tropical cyclone (TC) located near the neutral point of a split subtropical high pressure system under the influence of a nearby trough is difficult and can lead to a large forecast spread among different global numerical weather prediction models. Three TCs with large forecast spread under such an environmental flow pattern have been identified: Hagupit (2008), Lupit (2009) and Nida (2009). Simulations using a bogus vortex of different radii of 15 m·s−1 (R15) with the same environmental flow for each TC case are conducted to study the effect of TC size on the forecast track of the TC. With a nearby strong monsoon trough, a TC with a smaller R15 merges with the cyclonic circulation within the trough leading to a larger outer circulation. After removing the symmetric component of the TC from the total wind field, an extensive cyclonic asymmetric gyre is found and its circulation steers the TC to move more westward. The TC thus shifts northward within the neutral point. With a weak monsoon trough further away from the TC, a TC with larger R15 with a larger outer circulation interacts with the monsoon trough, causing the TC to move more westward. With the presence of a westerly trough, a TC with larger R15 and outer circulation interacts with the trough such that the TC moves more northeastward. The importance of a correct representation of TC size in a numerical weather prediction model in predicting the TC track is discussed.
Are oxidative stress and ischemia significant causes of bladder damage leading to lower urinary tract dysfunction? Report from the ICI‐RS 2019
Authors: Speich John E. , Tarcan Tufan , Hashitani Hikaru , Vahabi Bahareh , McCloskey Karen D. , Andersson Karl‐Erik , Wein Alan J. , Birder Lori A. 
Published: February 2020

AbstractSeveral studies indicate that pelvic ischemia and oxidative stress may play a significant role in lower urinary tract dysfunction (LUTD), including detrusor overactivity (DO)/overactive bladder (OAB) and detrusor underactivity (DU)/underactive bladder (UAB). The present article addresses proposal 1: “Are oxidative stress and ischemia significant causes of bladder damage leading to LUTD?” from the 2019 International Consultation on Incontinence—Research Society (ICI‐RS) meeting. Bladder ischemia in animals and humans is briefly described, along with the proposed progression from ischemia to LUTD. Bladder ischemia is compared with ischemia of other organs, and the ongoing development of pelvic ischemia animal models is discussed. In addition, the distribution of blood within the bladder during filling and voiding and the challenges of quantification of blood flow in vivo are described. Furthermore, oxidative stress, including potential biomarkers and treatments, and challenges regarding antioxidant therapy for the treatment of LUTD are discussed. Finally, seven critical research questions and proposed studies to answer those questions were identified as priorities that would lead to major advances in the understanding and treatment of lower urinary tract symptoms (LUTS)/LUTD associated with pelvic ischemia and oxidative stress.
Study on thermal, mechanical and morphological properties of recycled poly(vinyl chloride)/fly ash composites
Authors: Gohatre Omdeo Kishorrao , Biswal Manoranjan , Mohanty Smita , Nayak Sanjay K 
Published: February 2020

AbstractThe present study deals with the development of composite materials utilizing recycled poly(vinyl chloride) (r‐PVC) recovered from waste electrical and electronic materials and waste fly ash obtained from thermal power plants. The effect of the incorporation of fly ash on the mechanical, thermal and morphological properties of the r‐PVC matrix was studied. The primary characterization of r‐PVC and fly ash was done employing FTIR, EDX, particle size analysis and XRD analysis. Subsequently, fly ash with a particle size of approximately 9.29 μm was incorporated within the r‐PVC matrix. Composite sheets were prepared using a melt blending process followed by compression moulding. The mechanical test revealed an increase in the tensile strength and elongation at break of the r‐PVC/fly ash composite up to 30 wt% loading of fly ash beyond which there was a decrease in the tensile strength. The impact strength, however, decreased with increasing fly ash content in the r‐PVC matrix. The morphological properties of the composites showed a good distribution of the filler within the recycled matrix. The thermal properties of r‐PVC also improved with the incorporation of fly ash which was revealed from DSC and TGA studies. The water absorption test showed an increase in water uptake with the addition of fly ash in the r‐PVC matrix. © 2020 Society of Chemical Industry
Nanocellulose water treatment membranes and filters: a review
Authors: Mautner Andreas 
Published: February 2020

AbstractThis review covers the use of nanocelluloses in water treatment applications with particular focus on membranes and filters made either entirely from (nano)cellulose or in composite approaches. Nanocelluloses are among the emerging materials of this century, having found an abundance of potential applications in the fields of composites, medicine, functional additives or water treatment. Water treatment applications in particular have received significant academic and commercial attention, with a large variety of approaches developed in order to address arguably one of the largest problems that humanity is confronted with in the 21st century: clean water. In this regard, treatment of both potable water and wastewater is of high importance. The reason for the viability of nanocelluloses as base material relies upon their high specific surface area and abundance of OH groups that already exhibit certain attraction toward pollutants carrying ionic structures or dyes and also can be easily modified to significantly increase the affinity of nanocelluloses toward these pollutants. Nanocelluloses in their various forms (cellulose nanocrystals, cellulose nanofibrils, bacterial cellulose) have been applied in water treatment, with membranes and filters (size exclusion, e.g. for nanoparticle filtration, or affinity membranes) as well as adsorbents (e.g. heavy metal ions, dyes, nitrates) being the most studied. © 2020 The Author. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Star‐shaped polycaprolactone/chitosan composite hydrogels: fabrication and characterization
Authors: Ekapakul Natjaya , Irikura Koichi , Ajiro Hiroharu , Choochottiros Chantiga 
Published: February 2020

AbstractStar‐shaped polycaprolactone (stPCL)/chitosan composite hydrogel was fabricated by simply melt/solution blending between chitosan/dicarboxylic acid solution and melted stPCL, using 1‐(3‐dimethylaminopropyl)‐3‐ethylcarbodiimide hydrochloride and N‐hydroxysuccinimide as conjugating agents to obtain a composite hydrogel. Here, stPCL and modified stPCL were investigated. The stPCL was modified to have a carboxyl‐terminated chain (stPCL‐COOH). The composite hydrogels were transparent. The network structure of the composite hydrogels was investigated. stPCL‐OH had no chemical bond to the chitosan network but stPCL‐COOH could co‐crosslink with the chitosan network. The porous structure and porosity of the composite hydrogels were similar to those of chitosan hydrogel. However, the hydrophobicity of stPCL resulted in a lower swelling ratio compared to chitosan hydrogel. The rheological analysis of the composite hydrogel exhibited a stable crosslinked network. Compression testing of the composite hydrogel obtained from stPCL‐COOH at a mole ratio of stPCL‐COOH and chitosan of 1:1 had optimum compressive mechanical properties comparable to chitosan hydrogel due to a synergistic effect of the flexibility in stPCL and the co‐crosslinking of stPCL‐COOH with the chitosan network. © 2020 Society of Chemical Industry
Maximizing the applied value of structural models of psychopathology: Introduction to a special issue of Personality and Mental Health
Authors: Conway Christopher C. , Simms Leonard J. 
Published: February 2020

AbstractStructural models of mental illness delineate the major phenotypic dimensions of psychopathology. These evidence‐based models, such as the Hierarchical Taxonomy of Psychopathology, are poised to supplement—and even supplant—categorical diagnostic systems in research, assessment and treatment arenas. This special issue of Personality and Mental Health explores a new wave of research into structural models' utility for theory testing and clinical practice. Can structural approaches advance etiological research by clarifying connections between psychopathology and social, cultural, psychological and biological vulnerability processes? Can dimensional models of mental illness assimilate consensus models of temperament and personality? Can this paradigm identify optimal treatment targets and guide treatment design and selection? The studies compiled here all look beyond nosology to understand how structural models are changing research and clinical landscapes in mental health disciplines. We envision this set of articles as a blueprint for further investigation into the configuration, research utility and clinical application of structural approaches to diagnostic classification. © 2020 John Wiley & Sons, Ltd.
Miro: A molecular switch at the center of mitochondrial regulation
Authors: Eberhardt Emily L. , Ludlam Anthony V. , Tan Zhenyu , Cianfrocco Michael A. 
Published: February 2020

AbstractThe orchestration of mitochondria within the cell represents a critical aspect of cell biology. At the center of this process is the outer mitochondrial membrane protein, Miro. Miro coordinates diverse cellular processes by regulating connections between organelles and the cytoskeleton that range from mediating contacts between the endoplasmic reticulum and mitochondria to the regulation of both actin and microtubule motor proteins. Recently, a number of cell biological, biochemical, and protein structure studies have helped to characterize the myriad roles played by Miro. In addition to answering questions regarding Miro's function, these studies have opened the door to new avenues in the study of Miro in the cell. This review will focus on summarizing recent findings for Miro's structure, function, and activity while highlighting key questions that remain unanswered.
Deep‐Q learning‐based heterogeneous earliest finish time scheduling algorithm for scientific workflows in cloud
Authors: Kaur Avinash , Singh Parminder , Singh Batth Ranbir , Peng Lim Chee 
Published: February 2020

SummaryThe complex and large‐scale scientific workflow applications are effectively executes on the cloud. The performance of cloud computing highly depends on the task scheduling. Optimal workflow scheduling is still a challenge that needs to be addressed due to the conflicting objectives and increasing demand for quality of service. Task scheduling is an NP‐hard problem due to its complexity. The newly introduced methods for resolving the problem of task scheduling are facing challenges to take the benefits of all aspects of cloud computing. In this article, we study the joint optimization of cost and makespan of scheduling workflows in infrastructure as a service clouds and propose a new workflow scheduling scheme using deep learning. In this scheme, a deep‐Q learning‐based heterogeneous earliest‐finish‐time (DQ‐HEFT) algorithm is developed, which closely integrates the deep learning mechanism with the task scheduling heuristic HEFT. The workflowsim simulator is used for the experiment of the real‐world and synthetic workflows. The experiment results demonstrate the efficiency of our proposed approach compared with existing algorithms. This technique can achieve significantly better makespan and speed metrics with a remarkably higher volume of data and can run faster compared with the existing workflow scheduling algorithms in cloud computing environment.
$$ T\overline{T},J\overline{T},T\overline{J} $$ partition sums from string theory
Authors: Hashimoto Akikazu , Kutasov David 
Published: February 2020

Abstract
We calculate the torus partition sum of a general CFT2 with left and right moving conserved currents J and $$ \overline{J} $$

J
¯

, perturbed by a combination of the irrelevant operators $$ T\overline{T},J\overline{T} $$
T

T
¯

,
J

T
¯

and $$ T\overline{J} $$
T

J
¯

. We use string theory techniques to write it as an integral transform of the partition sum of the unperturbed CFT with chemical potentials for the left and right moving conserved charges. The resulting expression transforms in the right way under the modular group, and reproduces the known spectrum of these models. We also derive a formula for the partition function of deformed CFT2 with non-vanishing chemical potentials.
IgG4-assoziierte Orbitopathie als wichtige Differenzialdiagnose eines fortgeschrittenen Silent-Sinus-Syndroms
Authors: Jurkov M. , Olze H. , Klauschen F. , Bertelmann E. , Schneider U. , Arens P. 
Published: February 2020

Abstract
Background
Immunoglobulin (Ig)G4-related disease is classified as an immune-mediated disease. The etiology of this condition has not been explained to date. Manifestations of the disease are diverse, and simultaneous involvement of multiple organs is not unusual.

Case report
We report the case of a patient referred to us after multiple unsuccessful paranasal sinus operations who presented with enophthalmos and a resultant migratory keratitis with a suspected diagnosis of silent sinus syndrome. Preservation of the orbit was no longer feasible. After five years without a definitive diagnosis, we ascertained that this was a case of IgG4-related disease.

Discussion
IgG4-related disease represents an important element in the differential diagnosis of chronic advanced diseases of the orbit and paranasal sinuses. The diagnosis should be considered in the case of unclear disease presentations. Typical histological findings include a storiform pattern of fibrosis, vasculopathy, and tissue infiltration by IgG4 plasma cells.
The role of acceleration and jerk in perception of above-threshold surge motion
Authors: de Winkel Ksander N. , Soyka Florian , Bülthoff Heinrich H. 
Published: February 2020

AbstractInertial motions may be defined in terms of acceleration and jerk, the time-derivative of acceleration. We investigated the relative contributions of these characteristics to the perceived intensity of motions. Participants were seated on a high-fidelity motion platform, and presented with 25 above-threshold 1 s forward (surge) motions that had acceleration values ranging between 0.5 and 2.5 $$\text {m/s}^2$$m/s2 and jerks between 20 and 60 $$\text {m/s}^3$$m/s3, in five steps each. Participants performed two tasks: a magnitude estimation task, where they provided subjective ratings of motion intensity for each motion, and a two-interval forced choice task, where they provided judgments on which motion of a pair was more intense, for all possible combinations of the above motion profiles. Analysis of the data shows that responses on both tasks may be explained by a single model, and that this model should include acceleration only. The finding that perceived motion intensity depends on acceleration only appears inconsistent with previous findings. We show that this discrepancy can be explained by considering the frequency content of the motions, and demonstrate that a linear time-invariant systems model of the otoliths and subsequent processing can account for the present data as well as for previous findings.
Recent findings in the genetics and epigenetics of asthma and allergy
Authors: Kabesch Michael , Tost Jörg 
Published: February 2020

AbstractIn asthma and allergy genetics, a trend towards a few main topics developed over the last 2 years. First, a number of studies have been published recently which focus on overlapping and/or very specific phenotypes: within the allergy spectrum but also reaching beyond, looking for common genetic traits shared between different diseases or disease entities. Secondly, an urgently needed focus has been put on asthma and allergy genetics in populations genetically different from European ancestry. This acknowledges that the majority of new asthma patients today are not white and asthma is a truly worldwide disease. In epigenetics, recent years have seen several large-scale epigenome-wide association studies (EWAS) being published and a further focus was on the interaction between the environment and epigenetic signatures. And finally, the major trends in current asthma and allergy genetics and epigenetics comes from the field of pharmacogenetics, where it is necessary to understand the susceptibility for and mechanisms of current asthma and allergy therapies while at the same time, we need to have scientific answers to the recent availability of novel drugs that hold the promise for a more individualized therapy.