bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Tool to Measure Nurses' Perceptions of Electronic Documentation: Exploratory Factor Analysis
Authors: Schenk Elizabeth C. , Brunelli Vanessa , Burduli Ekaterina 
Published: March 2020

Background and PurposeElectronic Health Records (EHRs) have been widely adopted in US hospitals. EHRs have changed workflow and time allocation and have broad impacts on staff. We adapted an existing instrument to measure nurses' perceptions of a newly adopted EHR.MethodsThe 11-item survey was administered to approximately 500 registered nurses in a mid-sized regional hospital in western US, with 153 responses received. Exploratory factor analysis (EFA) assessed the factor structure and Cronbach's α estimated internal consistency.ResultsA 3-factor model was retained through the EFA, and items were internally consistent (Cronbach's alpha for each subscale > .80).ConclusionsSurvey adaptation was iterative and resulted in a psychometrically sound and thematically relevant measure of nurses' EHR perceptions. Next steps include further psychometric evaluation and testing with additional samples.
Workplace Conflicts Among Emergency Department Nurses: Instrument Development and Psychometric Properties
Authors: Ganjizadeh Mohsen , Rahemi Zahra , Tafreshi Mansoureh Zagheri , Hajibagheri Ali , Ajorpaz Neda Mirbagher 
Published: March 2020

Background and PurposeConflicts in nursing workplace are frequent and can be resolved by individuals or groups. The purpose of this study was to develop a valid and reliable measure for the Workplace Conflicts among Emergency Department Nurses (WCEDN).MethodsA three-stage mixed methods study was conducted: (a) In-depth interviews with emergency department (ED) nurses were performed and themes were extracted from the data (b) Findings of the content analysis in combination with results of a literature review were examined, and preliminary instrument items were developed. The initial instrument comprised 50 items. (c) Content validity, face validity, content validity ratio, content validity index, and construct validity using exploratory factor analysis were performed.ResultsSubscales in the final instrument included Intrapersonal Conflict, Intragroup Conflict, Intergroup Conflict, and Causes of Conflict. Reliability of the instrument was .86, and the feasibility was 96.8%.ConclusionsThe final 40-item WCEDN demonstrated strong psychometric properties.
Psychometric Evaluation of the Caring Behaviors Inventory in Turkish Nurses and Patients
Authors: Gul Senay , Dinc Leyla 
Published: March 2020

Background and purposeInstruments developed specifically to measure nurse caring behaviors need to be assessed in different cultural contexts. The purpose was to translate the Caring Behaviors Inventory (CBI) into Turkish and evaluate its psychometric properties.MethodsThis was a methodological study with 356 nurses and 363 patients. Linguistic, content validity, and construct validity tested for the validity of scale. Internal consistency and test–retest were calculated for reliability of scale.ResultsExploratory factor analysis identified 30 items that could be categorized under three factors. Cronbach's α for the CBI was .97 for nurses and .99 for patients.ConclusionsThe Turkish version of the CBI is a valid and reliable instrument for measuring caring behaviors.
Negative Behavior Among Healthcare Professionals: Integrative Review of Instruments
Authors: Layne Diana M. , Nemeth Lynne S. , Mueller Martina 
Published: March 2020

BackgroundBehaviors that undermine a culture of safety pose a serious threat to the overall wellbeing of healthcare workers as well as to patient outcomes.PurposeThe purpose of this integrative review is to compare reported psychometrics, feasibility, and identify commonalities among available instruments measuring negative behaviors among healthcare professionals.MethodsWhittemore and Knafl's integrative review methods were used to analyze pertinent instruments designed to measure negative behaviors among healthcare professionals. Multiple computerized databases including CINAHL, MEDLINE, and Scopus databases were searched in the fall of 2017 without date restrictions.ResultsViolence, incivility, and bullying are the most frequently measured behaviors in healthcare workers, and a robust number of valid and reliable instruments are available.ConclusionsTo date a comprehensive review of psychometric properties and feasibility of administration is lacking. This review synthesizes the instruments measuring these behaviors, providing a resource for future research focused on mitigation and intervention strategies
A Practical Guide for Item Generation in Measure Development: Insights From the Development of a Patient-Reported Experience Measure of Compassion
Authors: Sinclair Shane , Jaggi Priya , Hack Thomas F. , McClement Susan E. , Cuthbertson Lena 
Published: March 2020

Background and PurposeAlthough various measure development guidelines exist, practical guidance on how to systematically generate items is nascent. This article provides practical guidance on item generation in measure development and the use of a Table of Specifications (TOS) in this process.MethodsIn addition to a review of the literature, the item generation process within an ongoing study to develop a valid and reliable patient-reported measure of compassion is provided.ResultsConsensus on an initial pool of 109 items and their response scale was achieved with the aid of a TOS.ConclusionsDynamic, experiential, and relational care constructs such as compassion lie at the heart of nursing. Practical guidance on item generation is needed to allow nurses to identify, measure, and improve compassion in research and practice.
Serviço Social no âmbito hospitalar
Authors: Vidal Michelli Ferrioli , Guilherme Rosilaine Coradini 
Published: March 2020

O presente artigo foi elaborado a partir da experiência como assistente social residente junto ao Programa de Residência Multiprofissional Integrada em Saúde da Universidade Federal do Pampa, Campus Uruguaiana-RS, especificamente na ênfase Urgência e Emergência, Turma 2017-2019. Objetiva-se explicitar os atuais desafios à materialização das Atribuições Privativas e Competências Profissionais do Assistente Social em Unidades de Pronto Socorro no âmbito hospitalar, a fim de relacioná-los a identidade atribuída ao profissional de Serviço Social nestas unidades. A discussão tornar-se relevante na medida em que tenciona dar visibilidade ao trabalho do profissional de Serviço Social no âmbito hospitalar, especificamente em Unidades de Pronto Socorro. Neste sentido, o presente artigo foi elaborado com base em uma pesquisa documental, a qual se caracterizou como qualitativa de natureza exploratória, assim como se estruturou baseada no método dialético-crítico. Ao final do estudo foi possível evidenciar que o Assistente Social encontra diversos desafios em seu espaço sócio ocupacional. Tendo que lidar com a contradição das ações médico assistenciais e as ações voltadas as proposições do Sistema Único de Saúde –SUS, que faz com que alguns profissionais que atuam em Unidade de Pronto Socorro não entendam o papel do profissional do Serviço Social. Em virtude disto o Assistente Social tem em seu contexto de trabalho uma realidade de resistência na defesa de sua identidade profissional, no intuito de materializar as suas Atribuições e Competências no âmbito hospitalar.
Analysis of Some Hematological and Biochemical Markers in Women Cancer Patients Receiving Doxorubicine Chemotherapy
Authors: Boulaares Islam  , Guemari Imane Yousra  , Derouiche Samir  
Published: March 2020

The goal of this study is to evaluate the effect of Doxorubicine chemotherapy on some biochemical and hematological markers in female cancer's patients. 22 cases of women cancer and control were chosen, Blood samples were collected from them and lipid profile, creatinine, urea levels and enzyme activities were measured. Also, erythrocyte and leucocyte line levels in blood was measured. Results of biochemical parameters revealed that a significant increase in serum lipid profile, creatinine level, LDH, GOT, GPT and GGT activities and no significant change in serum urea level in women with cancer compared to controls. On the other hand, Results of the haematological analysis show that RBC, HGB, HCT and lymphocyte (p <0.01) level are significant decreased in patients compared to control group and no significant change in WBC, Neutrophil , Monocyte , Eosinophil and basophile in patients compared to control group. In conclusion, the present study suggests that doxorubicin affect some biochemical and hematological marker of cardiac function indicating the cardiotoxic as a side effect of this treatment in cancer patients.
Empirical Evidence Demonstrating Injection Containment and Absence of Injection-Induced Fracturing, Wilmington Oil Field Case Study
Authors: Kellogg Ryan P. , Mercier David 
Published: March 2020

Summary
Waterfloods in California operate under the US Environmental Protection Agency's Class II underground injection control regulations, which are tasked with the protection of underground sources of drinking water (USDW) within the state. A key aspect of this regulatory framework is the operation of water injection wells under a maximum allowable surface pressure (MASP) to ensure that injected water does not induce and/or extend formation fractures that could create a potential conduit connecting the hydrocarbon zone with identified USDWs. Determination of the MASP for individual injection wells has typically been calculated using a step rate test (SRT), but this method has been shown to be inappropriate for multilayered, unconsolidated sandstone reservoirs (Ershaghi and Ershaghi 2018), which are prevalent in Wilmington Field. To avoid the potential for misinterpretation of SRTs to imply fracturing in this context, in this paper we summarize the evidence demonstrating both the effective geologic containment of injected fluid in the hydrocarbon-bearing zones and the absence of injection-induced fracturing. In addition, a series of field tests were conducted to assess the stress sensitivity of the Wilmington reservoirs and investigate in-situ changes in the reservoir at higher injection pressures by combining multirate injection tests with injection profile surveys. These results provide data supporting the noted challenges associated with MASP determination for multilayered, unconsolidated reservoirs. In this paper, we give operators and regulators working in these types of fields a framework for assessing both injection containment and injection-induced fracturing that account for the unique properties of these formations.
Coiled Tubing Adaptability in the Development of Shale Plays: 81 Days of Continuous Operation in the First UK Land Gas Shale Project
Authors: Fernandez C Diego A. , Franco D. Ernesto , Villagrana P. Carlos , Machado Ángel 
Published: March 2020

Abstract
This paper presents the procedures, best practices and results of a coiled tubing project on the first unconventional completion using the multistage fracturing technique onshore in the United Kingdom, to achieve commercial gas flow rates from the inland shale formations. The main goal of the coiled tubing operations was to deliver multiple hydraulic fracturing stages through the CT/tubing annulus in a single run; but the versatile technology was used for a wide range of intervention activities during the project.
Nilotinib, a Discoidin domain receptor 1 (DDR1) inhibitor, induces apoptosis and inhibits migration in breast cancer
Authors: Yu Shufang , Wang Shuang , Xie Yanping , Bao Aina , Li Jing , Ye Tingting , Yang Chu , Lin Bin , Yang Minghua 
Published: March 2020

Abstract
Background: Overexpression of Discoidin domain receptor 1(DDR1) is known to enhance the malignancy of breast cancer considerably. This study reports the identification of a potent DDR1 inhibitor, Nilotinib for the treatment of breast cancer.
Methods: MTT assay was used to evaluate the inhibitory activity of Nilotinib and meantime we used flow cytometry to evaluate the pro-apoptotic activity of Nilotinib against MCF-7 and MDA-MB-231. Expression of DDR1 was manipulated in MCF-7 cell lines with low level DDR1 expression by transfecting with plasmids containing by shRNA. The effect of DDR1 or treatment with Nilotinib on cell migration was assayed. The expression of p-DDR1, DDR1, p-ERK1/2, ERK1/2 and E-cadherin，Vimentin, Snail1 were detected by western blot and immuno-fluorescent staining .
Results: Nilotinib against MCF-7 (IC 50 =0.403 μM) and MDA-MB-231 (IC 50 =0.819 μM) and also indicated induced apoptotic cell death after co-cuturing with Nilotinib (500 nM), apoptosis rate is 29.60 % ± 2.19% and 18.75 % ± 2.30% respective ly. Moreover, Nilotinib effectually blocked cellular migration of MCF-7. Interestingly, Knock-down DDR1 could significantly block the migration of breast cancer, meantime the sensitivity of Nilotinib to MCF-7 was reduced.
Conclusion: Targeting DDR1 therapeutically could potentially affect survival and influence metabolism in breast cancer, and Nilotinib could as a candidate for the treatment of breast cancer.
Adipose-Derived Mesenchymal Stem Cells Attenuate Acute Lung Injury Through Regulation of the Gut Microbiota in Septic Rats
Authors: Sun Jun-Yi , Ding Xian-Fei , Liu Shao-Hua , Duan Xiao-Guang , Liang Huo-Yan , Sun Tong-Wen 
Published: March 2020

Abstract
Background: We hypothesized that adipose-derived mesenchymal stem cells (ADMSCs) may ameliorate sepsis-induced acute lung injury (ALI) by increasing or decreasing microorganism populations in the gut microbiota, such as that of Firmicutes and Bacteroidetes.Methods: A total of 60 male adult Sprague-Dawley (SD) rats were separated into three groups: the sham control (SC) group, the sepsis induced by cecal ligation and puncture (CLP) group, and the ADMSC treatment (CLP-ADMSCs) group, in which rats underwent the CLP procedure and then received 1 × 106 ADMSCs. Rats were sacrificed 24 hours after the SC or CLP procedures. To investigate the relationship between sepsis-induced ALI and the gut microbiota, rat lungs were histologically evaluated using hematoxylin and eosin (H&E) staining, serum levels of pro-inflammatory factors were detected using enzyme-linked immunosorbent assay (ELISA), and fecal samples were collected and analyzed using 16S rDNA sequencing.Results: The serum levels of inflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-6, were significantly increased in rats after the CLP procedure, but were significantly decreased in rats treated with ADMSCs. Histological evaluation of the rat lungs yielded results consistent with the changes in IL-6 levels among all groups. Treatment with ADMSCs significantly increased the diversity of the gut microbiota in rats with sepsis. The principal coordinates analysis (PCoA) results showed that there was a significant difference between the gut microbiota of the CLP-ADMSCs group and that of the CLP group. In rats with sepsis, the proportion of Bacteroides related to energy consumption and Escherichia–Shigella related to lipopolysaccharide production increased, and the proportion of Akkermansia related to the regulation of intestinal mucosal thickness and the maintenance of intestinal barrier function decreased. Furthermore, the proportion of Firmicutes related to energy storage, such as Verrucomicrobia, decreased. These changes in the gut microbiota break the energy balance, aggravate inflammatory reactions, reduce intestinal barrier functions, and promote the translocation of intestinal bacteria. Intervention with ADMSCs increased the proportion of beneficial bacteria, reduced the proportion of harmful bacteria, and normalized the gut microbiota, thus, improving the sepsis-induced ALI.Conclusions: Therapeutically administered ADMSCs may improve CLP-induced ALI by regulating the gut microbiota, providing a potential mechanism by which mesenchymal stem cells treat sepsis.
Interventions Carried Out In Primary Health Care To Deal With Overweight And Obesity - A Scoping Review
Authors: Souza Rafaela , Davies Vanessa Fernandes , Silva Rosana Mara da , Ferreira Joel Carlos Valcanai , Nickel Daniela Alba , Calvo Maria Cristina Marino , Lacerda Josimari Telino de 
Published: March 2020

Abstract
Introduction and objectives: overweight and obesity are important public health problems which have a negative impact on the quality of life of individuals and on health systems around the world. Primary Health Care (PHC) becomes a crucial health care model for addressing the problem of overweight and obesity. This study presents the protocol of a scoping review that aims to describe the interventions related to dealing with overweight and obesity in PHC, identifying the obstacles and facilitators for their implementation.Methods and Analysis : the scoping review protocol presented was based on the recommendations of the Prisma Extension for Scoping Reviews (PRISMA-SCR), as well as the framework proposed by Arksey and O’Malley. The research questions were elaborated by a multidisciplinary team of researchers, graduate students and professors belonging to a research group working in the area of ​​health policy and program evaluation. In addition, two pilot studies were carried out to refine the questions and to improve the online article research and consequently the protocol. The bibliometric databases that will be used are PUBMED, EBSCO, SCOPUS, WEB OF SCIENCE; using specific keywords for each database to orientate the search for original articles written in English. Every step of the research will be carried out by two researchers working independently. The steps include: searching the selected databases with the keywords; reading the title and summary of the articles found; reading the selected articles in full and transferring the data extracted from the articles to a table; a thematic analysis of the results.Ethics and Dissemination : the results of the scoping review will be published in a scientific journal and presented at conferences and other scientific events. It is hoped that the presentation and discussion of the findings of the scoping review proposed in this protocol can help researchers, health professionals and planners of PHC policies and programs to identify gaps in the literature, to reflect upon the experiments conducted around the world, and to explore possibilities for adapting successful interventions to varied geographical and cultural contexts.
SCO-AN:Improve Secrecy Capacity for Secure Transmission Using Power Allocation
Authors: Gu Yebo , Wu Zhilu , Yin Zhendong , Huang Bowen 
Published: March 2020

Abstract
Artificial noise(AN) is a core technique in physical layer security field which has been widely studied.AN reduces the channel capacity of eavesdroppers without affecting the channel capacity of the communicator so that AN can increase secrecy capacity.Secrecy capacity is defined as channel capacity of the communicator minus channel capacity of eavesdroppers.The AN is prohibited from affecting the channel capacity of the legal receiving channel. This condition brings good performance to AN as well as limitations.Recently, the secrecy capacity optimization artificial noise (SCO-AN) is proposed to increase the secrecy capacity more effectively.SCO-AN can reduce the channel capacity of the communicator to a small extent while greatly reducing the channel capacity of the eavesdropper. So, SCO-AN can further expand the secrecy capacity on the basis of AN. Due to the limitation of transmit power, SCO-AN cannot be added indefinitely, so it is an important issue to increase the secrecy capacity as much as possible under a certain power limit.In this paper, a secrecy capacity function with SCO-AN added under certain power constraints is established.Because this function is non-convex, the traditional convex optimization algorithm cannot be applied. A sequence quadratic program(SQP) is adopted to solve this power allocation problem.Simulation results show that SQP can effectively improve the secrecy capacity under a certain power limit.
Study on long noncoding RNA in enterovirus 71-induced severe hand-foot-mouth disease
Authors: Fang Fang , yi He , feng Xu 
Published: March 2020

Abstract
Background: To identify the critical type of severe hand-foot-mouth disease (HFMD) in early stage, long noncoding ribonucleic acid (LncRNA) microarray was used to screen specific LncRNA and to predictpossible pathogenesis and target genes of HFMD. Methods: Twenty cases of EV71-induced severe HFMD were collected in Children’s Hospital of Chongqing Medical University from September 2015 to September 2016. LncRNA microarray was used to analyze the expression of LncRNA and mRNA in peripheral blood of children between severe type and critical type, and then verify the validity by real-time polymerase chain reaction. Bioinformatic methods were used to investigate differentially expressed mRNA by gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Results: We obtained differentially expressed profiles of LncRNA and mRNA from peripheral blood of children with EV71-induced severe HFMD, and the number of LncRNA was 1949, the total mRNA profiles were 1422. GO analysis found that differentially expressed mRNAs were involved in the processes of immune response, immune defense, nucleic acid metabolism, and protein and molecule binding. KEGG analysis revealed that the differentially expressed mRNAs were involved in the p53 signaling pathway, NOD-like receptor signaling pathway, osteoblast differentiation, and so on. The target gene SLPI was closely related to the critical type of severe HFMD by cis/trans target gene prediction, and the pathogenic processes was regulated by LncRNA NR_038337. Conclusion: Since differentially expressed LncRNAs and mRNAs are present in severe HFMD, our findings provide a new method to explore the pathogenesis of the critical type of severe HFMD, andfurther study on specific LncRNA and target genes in critical type has great significance for diagnosis and treatment of severe HFMD. Keywords: Long noncoding RNA; Enterovirus 71; Severe hand-foot-mouth disease; Target gene Trial registration:ChiCTR-DCD-15007192.Registered 8 October,2015, http://www.chictr.org.cn/ ChiCTR-DCD-15007192