bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilization of COVID-19 Treatments and Clinical Outcomes among Patients with Cancer: A COVID-19 and Cancer Consortium (CCC19) Cohort Study
Authors: Rivera Donna R. , Peters Solange , Panagiotou Orestis A. , Shah Dimpy P. , Kuderer Nicole M. , Hsu Chih-Yuan , Rubinstein Samuel M. , Lee Brendan J. , Choueiri Toni K. , de Lima Lopes Gilberto , Grivas Petros , Painter Corrie A. , Rini Brian I. , Thompson Michael A. , Arcobello Jonathan , Bakouny Ziad , Doroshow Deborah B. , Egan Pamela C. , Farmakiotis Dimitrios , Fecher Leslie A. , Friese Christopher R. , Galsky Matthew D. , Goel Sanjay , Gupta Shilpa , Halfdanarson Thorvardur R. , Halmos Balazs , Hawley Jessica E. , Khaki Ali Raza , Lemmon Christopher A. , Mishra Sanjay , Olszewski Adam J. , Pennell Nathan A. , Puc Matthew M. , Revankar Sanjay G. , Schapira Lidia , Schmidt Andrew , Schwartz Gary K. , Shah Sumit A. , Wu Julie T. , Xie Zhuoer , Yeh Albert C. , Zhu Huili , Shyr Yu , Lyman Gary H. , Warner Jeremy L. 
Published: July 2020

AbstractAmong 2,186 U.S. adults with invasive cancer and laboratory-confirmed SARS-CoV-2 infection, we examined the association of COVID-19 treatments with 30-day all-cause mortality and factors associated with treatment. Logistic regression with multiple adjustments (e.g., comorbidities, cancer status, baseline COVID-19 severity) was performed. Hydroxychloroquine with any other drug was associated with increased mortality versus treatment with any COVID-19 treatment other than hydroxychloroquine or untreated controls; this association was not present with hydroxychloroquine alone. Remdesivir had numerically reduced mortality versus untreated controls that did not reach statistical significance. Baseline COVID-19 severity was strongly associated with receipt of any treatment. Black patients were approximately half as likely to receive remdesivir as white patients. Although observational studies can be limited by potential unmeasured confounding, our findings add to the emerging understanding of patterns of care for patients with cancer and COVID-19 and support evaluation of emerging treatments through inclusive prospective controlled trials.Significance:Evaluating the potential role of COVID-19 treatments in patients with cancer in a large observational study, there was no statistically significant 30-day all-cause mortality benefit with hydroxychloroquine or high-dose corticosteroids alone or in combination; remdesivir showed potential benefit. Treatment receipt reflects clinical decision-making and suggests disparities in medication access.This article is highlighted in the In This Issue feature, p. 1426
Treatment With a Marine Oil Supplement Alters Lipid Mediators and Leukocyte Phenotype in Healthy Patients and Those With Peripheral Artery Disease
Authors: Schaller Melinda S. , Chen Mian , Colas Romain A. , Sorrentino Thomas A. , Lazar Ann A. , Grenon S. Marlene , Dalli Jesmond , Conte Michael S. 
Published: July 2020

Background
Peripheral artery disease (PAD) is an advanced form of atherosclerosis characterized by chronic inflammation. Resolution of inflammation is a highly coordinated process driven by specialized pro‐resolving lipid mediators endogenously derived from omega‐3 fatty acids. We investigated the impact of a short‐course, oral, enriched marine oil supplement on leukocyte phenotype and biochemical mediators in patients with symptomatic PAD and healthy volunteers.

Methods and Results
This was a prospective, open‐label study of 5‐day oral administration of an enriched marine oil supplement, assessing 3 escalating doses in 10 healthy volunteers and 10 patients with PAD. Over the course of the study, there was a significant increase in the plasma level of several lipid mediator families, total specialized pro‐resolving lipid mediators, and specialized pro‐resolving lipid mediator:prostaglandin ratio. Supplementation was associated with an increase in phagocytic activity of peripheral blood monocytes and neutrophils. Circulating monocyte phenotyping demonstrated reduced expression of multiple proinflammatory markers (cluster of differentiation 18, 163, 54, and 36, and chemokine receptor 2). Similarly, transcriptional profiling of monocyte‐derived macrophages displayed polarization toward a reparative phenotype postsupplementation. The most notable cellular and biochemical changes over the study occurred in patients with PAD. There were strong correlations between integrated biochemical measures of lipid mediators (specialized pro‐resolving lipid mediators:prostaglandin ratio) and phenotypic changes in circulating leukocytes in both healthy individuals and patients with PAD.

Conclusions
These data suggest that short‐term enriched marine oil supplementation dramatically remodels downstream lipid mediator pathways and induces a less inflammatory and more pro‐resolution phenotype in circulating leukocytes and monocyte‐derived macrophages. Further studies are required to determine the potential clinical relevance of these findings in patients with PAD.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02719665.
Defining and Enabling ‘Justice’ for Victims/Survivors of Domestic Violence and Abuse
Authors: Aghtaie Nadia , Mulvihill Natasha , Abrahams Hilary , Hester Marianne 
Published: July 2020

Abstract
The article is based on a qualitative field study of how justice (in its wider sense) is understood by practitioners and religious leaders from Judaism, Islam and Christianity, who work with victims of domestic violence and abuse. The article focuses on two key questions: a) how do practitioners from the three faith communities conceptualise justice in relation to domestic violence and abuse (DVA)? b) how far do these practitioners believe that victims of DVA have access to justice within their respective faith communities? The findings suggest that the concept of structural spiritual abuse should be given more attention by the DVA literature and also by those who are working with women of faith.
Visuo-Proprioceptive Control of the Hand in Older Adults
Authors: Block Hannah J. , Sexton Brandon M. 
Published: July 2020

Abstract
To control hand movement, we have both vision and proprioception, or position sense. The brain is known to integrate these to reduce variance. Here we ask whether older adults integrate vision and proprioception in a way that minimizes variance as young adults do, and whether older subjects compensate for an imposed visuo-proprioceptive mismatch as young adults do. Ten healthy older adults (mean age 69) and 10 healthy younger adults (mean age 19) participated. Subjects were asked to estimate the position of visual, proprioceptive, and combined targets, with no direct vision of either hand. After a veridical baseline block, a spatial visuo-proprioceptive misalignment was gradually imposed by shifting the visual component forward from the proprioceptive component without the subject’s awareness. Older subjects were more variable than young subjects at estimating both visual and proprioceptive target positions. Older subjects tended to rely more heavily on vision than proprioception compared to younger subjects. However, the weighting of vision vs. proprioception was correlated with minimum variance predictions for both older and younger adults, suggesting that variance-minimizing mechanisms are present to some degree in older adults. Visual and proprioceptive realignment were similar for young and older subjects in the misalignment block, suggesting older subjects are able to realign as much as young subjects. These results suggest that intact multisensory processing in older adults should be explored as a potential means of mitigating degradation in individual sensory systems.
Retroactivating the Idea of the Avant Garde
Authors: Léger Marc James 
Published: July 2020

Abstract
In the late 1970s, Pierre Bourdieu argued that the field of cultural production was distinguished along class lines by three different modes of cultural habitus: bourgeois disinterestness, petty-bourgeois allodoxia and working-class necessity. Since that era, the petty-bourgeois habitus has become the dominant predisposition. Adding Bourdieu’s sociology of culture to Peter Bürger’s historicized theory of the emergence of the avant garde as a critique of the “institution art,” a new “avant garde hypothesis” becomes possible for today’s age of post-Fordist biocapitalism. Based on Jacques Lacan’s Four Discourses, the contemporary situation is shown to privilege specific forms of cultural production, in particular an activist Discourse of the Hysteric and a technocratic Discourse of the University. Psychoanalysis reveals the limits of these tendencies while also underscoring the archaic aspects of an aestheticist Discourse of the Master and the transferential logics of Analyst avant gardes.
Why Does a Colder (Warmer) Winter Tend to Be Followed by a Warmer (Cooler) Summer over Northeast Eurasia?
Authors: Chen Shangfeng , Wu Renguang , Chen Wen , Li Kai 
Published: July 2020

AbstractThis study reveals a pronounced out-of-phase relationship between surface air temperature (SAT) anomalies over northeast Eurasia in boreal winter and the following summer during 1980–2017. A colder (warmer) winter over northeast Eurasia tends to be followed by a warmer (cooler) summer of next year. The processes for the out-of-phase relation of winter and summer SAT involve the Arctic Oscillation (AO), the air–sea interaction in the North Atlantic Ocean, and a Eurasian anomalous atmospheric circulation pattern induced by the North Atlantic sea surface temperature (SST) anomalies. Winter negative AO/North Atlantic Oscillation (NAO)-like atmospheric circulation anomalies lead to continental cooling over Eurasia via anomalous advection and a tripolar SST anomaly pattern in the North Atlantic. The North Atlantic SST anomaly pattern switches to a dipolar pattern in the following summer via air–sea interaction processes and associated surface heat flux changes. The summer North Atlantic dipolar SST anomaly pattern induces a downstream atmospheric wave train, including large-scale positive geopotential height anomalies over northeast Eurasia, which contributes to positive SAT anomalies there via enhancement of downward surface shortwave radiation and anomalous advection. Barotropic model experiments verify the role of the summer North Atlantic SST anomalies in triggering the atmospheric wave train over Eurasia. Through the above processes, a colder winter is followed by a warmer summer over northeast Eurasia. The above processes apply to the years when warmer winters are followed by cooler summers except for opposite signs of SAT, atmospheric circulation, and SST anomalies.
Greater Future U.K. Winter Precipitation Increase in New Convection-Permitting Scenarios
Authors: Kendon Elizabeth J. , Roberts Nigel M. , Fosser Giorgia , Martin Gill M. , Lock Adrian P. , Murphy James M. , Senior Catherine A. , Tucker Simon O. 
Published: July 2020

AbstractFor the first time, a model at a resolution on par with operational weather forecast models has been used for national climate scenarios. An ensemble of 12 climate change projections at convection-permitting (2.2 km) scale has been run for the United Kingdom, as part of the UK Climate Projections (UKCP) project. Contrary to previous studies, these show greater future increases in winter mean precipitation in the convection-permitting model compared with the coarser (12 km) driving model. A large part (60%) of the future increase in winter precipitation occurrence over land comes from an increase in convective showers in the 2.2 km model, which are most likely triggered over the sea and advected inland with potentially further development. In the 12 km model, increases in precipitation occurrence over the sea, largely due to an increase in convective showers, do not extend over the land. This is partly due to known limitations of the convection parameterization scheme, used in conventional coarse-resolution climate models, which acts locally without direct memory and so has no ability to advect diagnosed convection over the land or trigger new showers along convective outflow boundaries. This study shows that the importance of accurately representing convection extends beyond short-duration precipitation extremes and the summer season to projecting future changes in mean precipitation in winter.
Prognostic factors for short-term patient mortality following interhospital transfers
Authors: Baykan Necmi , Aslaner Mehmet ali 
Published: July 2020

Introduction: The data on short-term mortality among patients following interhospital transfers remain uncertain in the literature, and particularly in Turkey. The aim of this study was to determine the characteristics of interhospital transfer patients and to investigate the factors associated with 72-h mortality. Methods: All interhospital transfer patients aged 16 years and above from a secondary care public hospital were evaluated retrospectively for the period January to December 2018. A total of 34 variables, including age, gender, date of transfer, referring unit, diagnosis, reason for transfer, transfer destination, waiting and transfer time, vitals, the Glasgow Coma Scale, the presence of intubation, cardiopulmonary resuscitation before transfer, and the use of vasopressor medication, were included in the univariate analysis. The factors associated with short-term mortality were identified by multivariate regression analysis. Results: During the 1-year study period, 1216 interhospital transfers were performed. A total of 116 (9.5%) patients died within 72 h following interhospital transfer. Among all the transfers, the median age was 62 (interquartile range, 39–76) years. According to the multivariate analysis, vasopressor use (odds ratio, 3.55; 95% confidence interval: 1.32–9.52), age (odds ratio, 1.01; 95% confidence interval: 1.00–1.03), pulse (odds ratio, 1.01; 95% confidence interval: 1.00–1.02), and diastolic blood pressure (odds ratio, 0.97; 95% confidence interval: 0.95–0.99) were predictive of 72-h mortality following interhospital transfer. Conclusion: Nearly 10% of all the transfers from the secondary care public hospital resulted in mortality within 72 h. Vasopressor use, advanced age, lower diastolic blood pressure, and tachycardia were the most important factors associated with short-term mortality.
Zanubrutinib for the treatment of patients with Waldenström macroglobulinemia: 3 years of follow-up
Authors: Trotman Judith , Opat Stephen , Gottlieb David , Simpson David , Marlton Paula , Cull Gavin , Munoz Javier , Tedeschi Alessandra , Roberts Andrew W. , Seymour John F. , Atwal Siminder Kaur , Yu Yiling , Novotny William , Holmgren Eric , Tan Ziwen , Hilger James D. , Huang Jane , Tam Constantine S. 
Published: July 2020

Abstract
Inhibitors of Bruton’s tyrosine kinase (BTK) have established therapeutic activity in patients with Waldenström macroglobulinemia (WM). Zanubrutinib, a potent and selective BTK inhibitor, was evaluated in a phase 1/2 study in patients with WM who were either treatment-naïve (TN) or had relapsed/refractory (R/R) disease. Patients had disease requiring treatment per International Workshop on Waldenström Macroglobulinemia (IWWM) criteria. Treatment was 160 mg of oral zanubrutinib twice daily (n = 50) or 320 mg once daily (n = 23). Efficacy endpoints included overall response rate (ORR) and very good partial response/complete response (VGPR/CR) rates per IWWM-6 criteria (with modification of VGPR definition published previously). Between September 2014 and March 2018, 77 patients (24 TN and 53 R/R) began treatment. At a median follow-up of 36.0 months for patients with R/R disease and 23.5 months for TN, 72.7% remained on treatment. Reasons for treatment discontinuation included any adverse events in 13.0% of patients (1 treatment related), disease progression (10.4%), and other (3.9%). The ORR was 95.9%, and the VGPR/CR rate was 45.2%, which increased over time: 20.5% at 6 months, 32.9% at 12 months, and 43.8% at 24 months. Estimated 3-year progression-free survival rate was 80.5%, and overall survival rate was 84.8%. Adverse events of interest included contusion (32.5%, all grade 1), neutropenia (18.2%), major hemorrhage (3.9%), atrial fibrillation/flutter (5.2%), and grade 3 diarrhea (2.6%). Long-term treatment with single-agent zanubrutinib resulted in deep and durable responses in some patients with WM. The safety profile of long-term zanubrutinib therapy in these patients was acceptable. This trial was registered at www.clinicaltrials.gov as #NCT02343120.
Complement inhibition does not impair the clinical antiviral capabilities of virus-specific T-cell therapy
Authors: Rubinstein Jeremy D. , Zhu Xiang , Lutzko Carolyn , Leemhuis Tom , Cancelas Jose A. , Jodele Sonata , Bollard Catherine M. , Hanley Patrick J. , Davies Stella M. , Grimley Michael S. , Nelson Adam S. 
Published: July 2020

Key Points
The use of terminal complement blockade is compatible with virus-specific T-cell (VST) expansion and clinical effectiveness. VST and complement-blocking agent concurrent therapy may be safely used in patients with thrombotic microangiopathy and viral infections.
Characterization, identification and expression profiling of genome-wide R-genes in melon and their putative roles in bacterial fruit blotch resistance
Authors: Islam Md. Rafiqul , Hossain Mohammad Rashed , Jesse Denison Michael Immanuel , Jung Hee-Jeong , Kim Hoy-Taek , Park Jong-In , Nou Ill-Sup 
Published: July 2020

Abstract
Background
Bacterial fruit blotch (BFB), a disease caused by Acidovorax citrulli, results in significant economic losses in melon. The causal QTLs and genes for resistance to this disease have yet to be identified. Resistance (R)-genes play vital roles in resistance to plant diseases. Since the complete genome sequence of melon is available and genome-wide identification of R-genes has been performed for this important crop, comprehensive expression profiling may lead to the identification of putative candidate genes that function in the response to BFB.

Results
We identified melon accessions that are resistant and susceptible to BFB through repeated bioassays and characterized all 70 R-genes in melon, including their gene structures, chromosomal locations, domain organizations, motif distributions, and syntenic relationships. Several disease resistance-related domains were identified, including NBS, TIR, LRR, CC, RLK, and DUF domains, and the genes were categorized based on the domains of their encoded proteins. In addition, we profiled the expression patterns of the genes in melon accessions with contrasting levels of BFB resistance at 12 h, 1 d, 3 d, and 6 d after inoculation with A. citrulli. Six R-genes exhibited consistent expression patterns (MELO3C023441, MELO3C016529, MELO3C022157, MELO3C022146, MELO3C025518, and MELO3C004303), with higher expression levels in the resistant vs. susceptible accession.

Conclusion
We identified six putative candidate R-genes against BFB in melon. Upon functional validation, these genes could be targeted for manipulation via breeding and biotechnological approaches to improve BFB resistance in melon in the future.
Outcome impact of individualized fluid management during spine surgery: a before-after prospective comparison study
Authors: Che Lu , Zhang Xiu H. , Li Xu , Zhang Yue L. , Xu Li , Huang Yu G. 
Published: July 2020

Abstract
Background
Individualized fluid management (IFM) has been shown to be useful to improve the postoperative outcome of patients undergoing major abdominal surgery. A limited number of clinical studies have been done in orthopaedic patients and have yielded conflicting results. We designed the present study to investigate the clinical impact of IFM in patients undergoing major spine surgery.

Methods
This is a before-after study done in 300 patients undergoing posterior spine arthrodesis. Postoperative outcomes were compared between control group implementing standard fluid management (n = 150) and IFM group (n = 150) guided by fluid protocol based on continuous stroke volume monitoring and optimization. The primary outcome measure was the proportion of patients who developed one or more complications within 30 days following surgery.

Results
During surgery, patients received on average the same volume of crystalloids (7.4 vs 7.2 ml/kg/h) and colloids (1.6 vs 1.6 ml/kg/h) before and after the implementation of IFM. During 30 days following surgery, the proportion of patients who developed one or more complications was lower in the IFM group (32 vs 48%, p < 0.01). This difference was mainly explained by a significant decrease in post-operative nausea and vomiting (from 38 to 19%, p < 0.01), urinary tract infections (from 9 to 1%, p < 0.01) and surgical site infections (from 5 to 1%, p < 0.05). Median hospital length of stay was not affected by the implementation of IFM.

Conclusion
In patients undergoing major spine surgery, the implementation of IFM was associated with a significant decrease in postoperative morbidity.

Trial registration
ClinicalTrials.gov Identifier: NCT02470221. Prospectively registered on June 12, 2015.
Sero-prevalence of hepatitis B virus markers and associated factors among children in Hawassa City, southern Ethiopia
Authors: Argaw Bedru , Mihret Adane , Aseffa Abraham , Tarekegne Azeb , Hussen Siraj , Wachamo Demelash , Shimelis Techalew , Howe Rawleigh 
Published: July 2020

Abstract
Background
Hepatitis B virus (HBV) infection is one of the major public health problems worldwide. Limited information exists about the epidemiology of HBV infection in Ethiopia. This study aimed to assess sero-prevalence of HBV markers and associated factors in children living in Hawassa City, southern Ethiopia.

Methods
A community-based cross-sectional study was conducted among 471 children in Hawassa City, southern Ethiopia from May to September, 2018. A total of 471 children were included in the study using a multistage sampling technique. Data on demographic and risk factors were gathered using structured questionnaires. Blood samples were collected and sera were screened for hepatitis B surface antigen (HBsAg), antibody to core antigen (anti-HBc), and antibody against surface antigen (anti-HBs) using enzyme-linked immunosorbent assay.

Results
The sero-prevalence of HBsAg, anti-HBc, and anti-HBs markers among children were 4.4, 19.5 and 20.0%, respectively. Children at higher risk of having HBsAg marker were those who had a history of injectable medications (AOR 5.02, 95% CI: 1.14, 22.07), a family history of liver disease (AOR 6.37, 95% CI: 1.32, 30.74), a HBsAg seropositive mothers, (AOR 11.19, (95% CI: 3.15, 39.67), and had no vaccination history for HBV (AOR, 6.37, 95% CI: 1.32, 30.74). Children from families with low monthly income, who were home delivered, unvaccinated for HBV or with HBsAg seropositive mother had increased risk of having anti-HBc.

Conclusions
The study findings showed an intermediate endemicity of HBV infection in the study setting. The observed rate of residual HBV infection with low rate of immunized children after HBV vaccination was high. Hence, introducing birth dose vaccine, safe injection practice and improving immunization coverage during pregnancy as part of the antenatal care package should be considered. Furthermore, governmental and non-governmental organizations should give attention on timely measures for the prevention of ongoing vertical transmission from mother to child as well as early horizontal transmission of HBV in Hawassa City, Ethiopia.