bluuebunny/crossref_metadata_2025_split huggingface dataset:
Giant Cell Tumor of Triquetrum: A Case Report with Literature Review
Authors: Ansari Mohammed T. , Digge Vijay K. , Mahmood Asjad 
Published: July 2020

Abstract
Background Giant cell tumor (GCT) of bone is a benign, aggressive tumor of bone and occurs commonly around the knee and distal radius. GCT of bone rarely occurs in hand. In hand, metacarpals are the most common site and there have been only a few case reports of GCT of the carpal bone. In hand, these tumors are very aggressive and these have a high tendency to recur after intralesional curettage. No long-term study is available for choosing an appropriate method of treatment for these tumors in hand.
Case Description Herein, we report a case of GCT of the bone involving triquetrum which was managed by excision of triquetrum and scaphoid bone. The reconstruction of the wrist was done through limited carpal fusion, by doing three corner fusion of the wrist. At 2 years after surgery, the patient was asymptomatic and radiographs revealed fusion of lunocapitate and lunohamate joints with no evidence of recurrence.
Literature review Current literature regarding GCT of triquetrum includes case reports that are reviewed in this report.
Clinical Relevance This case illustrates the successful treatment of GCT of triquetrum, which is a rare tumor. Three-corner fusion is a reliable and reproducible procedure that has been used for other arthritic conditions. The use of three corner fusion procedure can be extended to GCT of carpal bones. It has been a motion-preserving alternative to proximal row carpectomy.
The sealing properties of magnetorheological fluids under quasi-static tensile
Authors: Zheng Ji-Nan , Li Yu-Zheng , Chen Chen , Chen Shu-Mei 
Published: July 2020

Abstract
In order to study the influences of sealing gap on the seal of magnetorheological fluids (MRF), the quasi-static tensile tests along the direction of magnetic field have been carried out by using a commercial plate-plate rheometer. Based on the experimental results, the relationships among the height of sealing gap, magnetic field intensity, particle concentration and the sealing properties of MRF are discussed. The analysis results show that the sealing performances of MRF will deteriorate with the increase of sealing gap, especially when the MRF is exposed to a strong magnetic field. This is probably due to the fact that the material properties of MRF become more similar to the solid with the rise of magnetic field, which makes the sealing layer more brittle and prone to leakage. The tensile process in low magnetic field can be divided into the forming of seal region, stable seal, leak and balanced-pressure four stages, in which the stable seal stage shows that the MRF has certain self-healing ability of seal. Furthermore, both the initial compressive strength and the sealing stability of MRF can be significantly improved by increasing the volume fraction of MRF. Finally, a theoretical model for calculating the burst pressure of MRF seal is proposed according to the theory of magnetic dipole. The description of the relationship between various influencing factors and the sealing characteristics of MRF by this model is consistent with the experimental results, which indicates that the model has favorable instructing value in the practical engineering application.
Character Adaptations: Recurrence and Return
Authors: Strong Jeremy 
Published: July 2020

AbstractThis paper examines recurring character storytelling as the most prodigiously successful tradition in fiction of the last two hundred years. James Fenimore Cooper’s Leatherstocking Tales and Honoré de Balzac’s La Comédie humaine are proposed as significant precursors that embody two dominant trends within recurring character storytelling: the central protagonist series and the populous storyworld. The foundations of recurring character storytelling are traced in a range of determinants including: increasing literacy and the rise of popular genres; modes of serial publication; and the development and enforcement of copyright law. Finally, focusing upon the central protagonist variant, the age and aging of recurring characters are discussed as a necessary consideration for the makers and adapters of such series. Several are analysed, including James Bond, Sharpe, the Morse franchise, and Midsomer Murders, to illuminate how makers handle chronology, the passage of time, and related issues in adaptation. As part of an assessment of the ‘affordances’ of recurring character fictions, nostalgia and familiarity are discussed as significant dimensions of the experience they furnish.
Review of 189 Consecutive Female Genital Skin and Mucosal Biopsies Submitted to an Academic Dermatopathology Practice
Authors: Joehlin-Price Amy S , Mully Thaddeus W 
Published: July 2020

Abstract

Objectives
To describe consecutive vulvar biopsy cases and to create an educational template for pathology trainees and practicing pathologists.

Methods
We reviewed 189 consecutive biopsies from the female genital area skin and mucosa. We classified them based on etiologies and examined limited clinical information.

Results
We classified diagnoses as squamous intraepithelial neoplasia (21.5%), melanocytic neoplasia (17.9%), lichenoid dermatoses (15.9%), nonlichenoid dermatoses (11.3%), infectious (6.2%), reparative (4.6%), or miscellaneous (22.6%). The miscellaneous diagnoses included common entities (polyps and cysts) and rarer entities (calcinosis cutis, adnexal neoplasms, or basal cell carcinoma) and nonspecific descriptive diagnoses. Clinicians most often included the actual diagnosis in their differential for melanocytic lesions (83%) and least often for inflammatory lesions (32%). However, some cases included a clinical description without a differential diagnosis (14%) or no helpful clinical information (4%). The distribution of whether correct diagnoses were included in the clinical differential was similar between submitting physicians and midlevel providers.

Conclusions
Understanding squamous and melanocytic pathology and the various lichenoid and other inflammatory diagnoses is critical for signing out female genital tract skin pathology. The cases examined in this report can serve as an educational template for trainees and practicing pathologists.
NCBI Taxonomy: a comprehensive update on curation, resources and tools
Authors: Schoch Conrad L , Ciufo Stacy , Domrachev Mikhail , Hotton Carol L , Kannan Sivakumar , Khovanskaya Rogneda , Leipe Detlef , Mcveigh Richard , O’Neill Kathleen , Robbertse Barbara , Sharma Shobha , Soussov Vladimir , Sullivan John P , Sun Lu , Turner Seán , Karsch-Mizrachi Ilene 
Published: July 2020

AbstractThe National Center for Biotechnology Information (NCBI) Taxonomy includes organism names and classifications for every sequence in the nucleotide and protein sequence databases of the International Nucleotide Sequence Database Collaboration. Since the last review of this resource in 2012, it has undergone several improvements. Most notable is the shift from a single SQL database to a series of linked databases tied to a framework of data called NameBank. This means that relations among data elements can be adjusted in more detail, resulting in expanded annotation of synonyms, the ability to flag names with specific nomenclatural properties, enhanced tracking of publications tied to names and improved annotation of scientific authorities and types. Additionally, practices utilized by NCBI Taxonomy curators specific to major taxonomic groups are described, terms peculiar to NCBI Taxonomy are explained, external resources are acknowledged and updates to tools and other resources are documented.Database URL: https://www.ncbi.nlm.nih.gov/taxonomy
Long-term experience with the one-and-a-half ventricle repair for simple and complex congenital heart defects
Authors: Cabrelle Giulio , Castaldi Biagio , Vedovelli Luca , Gregori Dario , Vida Vladimiro L , Padalino Massimo A 
Published: July 2020

Abstract

OBJECTIVES

The one-and-a-half ventricle repair (1.5VR) is a surgical alternative to Fontan circulation or high-risk biventricular repair in patients with complex congenital heart disease (CHD) with a hypoplastic right ventricle (RV). We report our 25 years of experience to evaluate whether the degree of anatomical complexity of the CHD can affect long-term outcomes.

METHODS
This is a retrospective study including patients undergoing 1.5VR between 1994 and 2018. Clinical records and operative reports were reviewed. Follow-up data were collected from all survivors at the last evaluation or by phone contact.

RESULTS
Twenty-nine patients underwent 1.5VR [median age: 3.5 years, interquartile range (IQR) 0.8–7.8]. Fifteen patients had ‘simple’ (i.e. confined to right heart lesions) anatomical characteristics (48.3%); the median tricuspid valve annulus z-score was −3.5 (IQR −6.2 to +3.6). There were no operative deaths. The median hospital stay was 21 days (IQR 10–33), with postoperative complications in 21 patients (75.8%). At a median follow-up of 13.2 years (IQR 3.2–25.6 years; completeness 96.6%), there were 3 late deaths. There was no significant difference in survival and in freedom from adverse events between simple and complex anatomy groups. However, stress test findings showed a tendency towards a higher maximum oxygen uptake in the simple group (P = 0.055).

CONCLUSIONS
The 1.5VR strategy is an effective low-risk surgical option for patients with CHD with hypoplastic RV. When it is planned from birth, late outcomes can be satisfactory. In our experience, the presence of associated major cardiac anomalies was not associated with either worse early or long-term outcomes and functional status.
Molecular tumor classification using DNA methylome analysis
Authors: Sill Martin , Plass Christoph , Pfister Stefan M , Lipka Daniel B 
Published: July 2020

AbstractTumor classifiers based on molecular patterns promise to define and reliably classify tumor entities. The high tissue- and cell type-specificity of DNA methylation, as well as its high stability, makes DNA methylation an ideal choice for the development of tumor classifiers. Herein, we review existing tumor classifiers using DNA methylome analysis and will provide an overview on their emerging impact on cancer classification, the detection of novel cancer subentities and patient stratification with a focus on brain tumors, sarcomas and hematopoietic malignancies. Furthermore, we provide an outlook on the enormous potential of DNA methylome analysis to complement classical histopathological and genetic diagnostics, including the emerging field of epigenomic analysis in liquid biopsies.
Identifying psychiatric diagnostic errors with the Safer Dx Instrument
Authors: Fletcher Terri L , Helm Ashley , Vaghani Viralkumar , Kunik Mark E , Stanley Melinda A , Singh Hardeep 
Published: July 2020

AbstractObjectiveDiagnostic errors in psychiatry are understudied partly because they are difficult to measure. The current study aimed to adapt and test the Safer Dx Instrument, a structured tool to review electronic health records (EHR) for errors in medical diagnoses, to evaluate errors in anxiety diagnoses to improve measurement of psychiatric diagnostic errors.DesignThe iterative adaptation process included a review of the revised Safer Dx-Mental Health Instrument by mental health providers to ensure content and face validity and review by a psychometrician to ensure methodologic validity and pilot testing of the revised instrument.SettingsNone.ParticipantsPilot testing was conducted on 128 records of patients diagnosed with anxiety in integrated primary care mental health clinics. Cases with anxiety diagnoses documented in progress notes but not included as a diagnosis for the encounter (n = 25) were excluded.Intervention(s)None.Main Outcome Measure(s)None.ResultsOf 103 records meeting the inclusion criteria, 62 likely involved a diagnostic error (42 from use of unspecified anxiety diagnosis when a specific anxiety diagnosis was warranted; 20 from use of unspecified anxiety diagnosis when anxiety symptoms were either undocumented or documented but not severe enough to warrant diagnosis). Reviewer agreement on presence/absence of errors was 88% (κ = 0.71).ConclusionThe revised Safer Dx-Mental Health Instrument has a high reliability for detecting anxiety-related diagnostic errors and deserves testing in additional psychiatric populations and clinical settings.
Evaluation of standardized automated rapid antimicrobial susceptibility testing of Enterobacterales-containing blood cultures: a proof-of-principle study
Authors: Mancini Stefano , Bodendoerfer Elias , Kolensnik-Goldmann Natalia , Herren Sebastian , Röthlin Kim , Courvalin Patrice , Böttger Erik C 
Published: July 2020

Abstract

Background
Rapid antimicrobial susceptibility testing (RAST) of bacteria causing bloodstream infections is critical for implementation of appropriate antibiotic regimens.

Objectives
We have established a procedure to prepare standardized bacterial inocula for Enterobacterales-containing clinical blood cultures and assessed antimicrobial susceptibility testing (AST) data generated with the WASPLabTM automated reading system.

Methods
A total of 258 blood cultures containing Enterobacterales were examined. Bacteria were enumerated by flow cytometry using the UF-4000 system and adjusted to an inoculum of 106 cfu/mL. Disc diffusion plates were automatically streaked, incubated for 6, 8 and 18 h and imaged using the fully automated WASPLabTM system. Growth inhibition zones were compared with those obtained with inocula prepared from primary subcultures following the EUCAST standard method. Due to time-dependent variations of the inhibition zone diameters, early AST readings were interpreted using time-adjusted tentative breakpoints and areas of technical uncertainty.

Results and conclusions
Inhibition zones obtained after 18 h incubation using an inoculum of 106 cfu/mL prepared directly from blood cultures were highly concordant with those of the EUCAST standard method based on primary subcultures, with categorical agreement (CA) of 95.8%. After 6 and 8 h incubation, 89.5% and 93.0% of the isolates produced interpretable results, respectively, with CA of &gt;98.5% and very low numbers of clinical categorization errors for both the 6 h and 8 h readings. Overall, with the standardized and automated RAST method, consistent AST data from blood cultures containing Enterobacterales can be generated after 6–8 h of incubation and subsequently confirmed by standard reading of the same plate after 18 h.
Present status of support for adolescent and young adult cancer patients in member hospitals of Japanese Association of Clinical Cancer Centers
Authors: Nakayama Hideki , Toh Yasushi , Fujishita Manami , Nakagama Hitoshi 
Published: July 2020

Abstract

Background
the proportion of adolescent and young adult cancer patients is relatively small, but they require age-specific support. We conducted a survey on the present status of support for adolescent and young adult cancer patients in the Japanese Association of Clinical Cancer Centers.

Methods
in December 2018, the primary questionnaires were sent to 32 hospitals of Japanese Association of Clinical Cancer Centers regarding support for adolescent and young adult cancer patients. Secondary questionnaires were sent to doctors, nurses and medical social workers in 24 hospitals for the implementation rates of information provision and consultation on 17 unmet needs identified in the study by the Ministry of Health, Labour and Welfare, Japan.

Results
there were marked differences in support for adolescent and young adult cancer patients among hospitals. Only one hospital facilitated an adolescent and young adult department and ward. Thirteen hospitals cooperated with the paediatric cancer designated hospitals. A learning support for high school-aged patients was provided in 15 hospitals. Adolescent and young adult support teams were active in seven hospitals and staff training sessions were held in eight hospitals. Many hospitals had referrals for fertility preservation. The rates of information provision and consultation for more than 70% of adolescent and young adult patients showed statistically significant differences among the medical professions in most of the 17 items.

Conclusions
support systems and activities for adolescent and young adult cancer patients vary extremely across hospitals. Information provision and consultation for unmet needs are still insufficient. Therefore, sharing information and experiences is required to enhance the support for adolescent and young adult cancer patients.
Comparison of Acellular Solutions for Ex-situ Perfusion of Amputated Limbs
Authors: Haug Valentin , Kollar Branislav , Endo Yori , Kadakia Nikita , Veeramani Anamika , Kauke Martin , Tchiloemba Bianief , Klasek Robin , Pomahac Bohdan 
Published: July 2020

Abstract

Introduction
Hypothermic ex-situ machine perfusion (MP) has been shown to be a promising alternative to static cold storage (SCS) for preservation of solid organs for transplantation and vascularized composite allotransplantation. Perfusion with blood-based perfusion solutions in austere environments is problematic due to their need for appropriate storage and short shelf life, making it impractical for military and emergency use. Acellular perfusion has been shown to be effective, but the ideal perfusate solution for MP of amputated limbs is yet to be determined. The purpose of this study is to evaluate the efficacy of alternative perfusate solutions, such as dextran-enriched Phoxilium, Steen, and Phoxilium in ex-vivo hypothermic MP of amputated limbs in a porcine model.

Materials and methods
Amputated forelimbs from Yorkshire pigs (n = 8) were preserved either in SCS (n = 2) at 4°C for 12 hours or machine-perfused at 10°C for 12 hours with oxygenated perfusion solutions (n = 6) at a constant flow rate. The perfusates used include modified Steen-solution, Phoxilium (PHOX), or Phoxilium enriched with dextran-40 (PHODEX). The perfusate was exchanged after 1 and 6 hours of perfusion. Machine data were recorded continuously. Perfusate samples for clinical chemistry, blood gas analysis, and muscle biopsies were procured at specific timepoints and subsequently analyzed. In this semi in-vivo study, limb replantation has not been performed.

Results
After amputation, every limb was successfully transferred and connected to our perfusion device. The mean total ischemia time was 77.5 ± 5.24 minutes. The temperature of the perfusion solution was maintained at 10.18 ± 2.01°C, and perfusion pressure at 24.48 ± 10.72 mmHg. Limb weight increased by 3% in the SCS group, 36% in the PHODEX group, 25% in the Steen group, and 58% in the PHOX group after 12 hours. This increase was significant in the PHOX group compared with the SCS group. All perfusion groups showed a pressure increase of 10.99 mmHg over time due to edema. The levels of HIF-1a decreased over time in all groups except the Steen and the PHODEX group. The biomarkers of muscle injury in the perfusate samples, such as creatine kinase and lactate-dehydrogenase, showed a significant difference between groups, with highest values in the PHODEX group. No significant differences were found in the results of the blood gas analysis.

Conclusion
With the exception of significantly higher levels of creatine kinase and lactate dehydrogenase, MP with dextran-enriched Phoxilium provides similar results as that of the commercially available perfusates such as Steen, without the need for cold storage, and at circa 5% of the cost of the Steen solution. Further large-scale replantation studies are necessary to evaluate the efficacy of dextran-enriched Phoxilium as an alternate perfusate solution.
One-point probability distribution function from spherical collapse: early dark energy versus ΛCDM
Authors: Mandal Ankush , Nadkarni-Ghosh Sharvari 
Published: July 2020

ABSTRACT
We compute the one-point probability distribution function (PDF) of an initially Gaussian dark matter density field using spherical collapse (SC). We compare the results to other forms available in the literature and also compare the PDFs in the Λ-cold dark matter model with an early dark energy (EDE) model. We find that the skewed lognormal distribution provides the best fit to the non-linear PDF from SC for both cosmologies, from a = 0.1 to 1 and for scales characterized by the comoving width of the Gaussian: σG = 0.5, 1, and 2. To elucidate the effect of cosmology, we examine the linear and non-linear growth rates through test cases. For overdensities, when the two models have the same initial density contrast, the differences due to cosmology are amplified in the non-linear regime, whereas, if the two models have the same linear density contrast today, then the differences in cosmology are damped in the non-linear regime. This behaviour is in contrast with voids, where the non-linear growth becomes ‘self-regulatory’ and is less sensitive to cosmology and initial conditions. To compare the PDFs, we examine the difference of the PDFs and evolution of the width of the PDF. The trends with scale and redshift are as expected. A tertiary aim of this paper was to check if the fitting form for the non-linear density–velocity divergence relation, derived for constant equation of state (w) models by Nadkarni-Ghosh holds for the EDE model. We find that it does with an accuracy of 4 per cent, thus increasing its range of validity.
The dichotomy of atmospheric escape in AU Mic b
Authors: Carolan S , Vidotto A A , Plavchan P , Villarreal D’Angelo C , Hazra G 
Published: July 2020

ABSTRACT
Here, we study the dichotomy of the escaping atmosphere of the newly discovered close-in exoplanet AU Microscopii (AU Mic) b. On one hand, the high extreme-ultraviolet stellar flux is expected to cause a strong atmospheric escape in AU Mic b. On the other hand, the wind of this young star is believed to be very strong, which could reduce or even inhibit the planet’s atmospheric escape. AU Mic is thought to have a wind mass-loss rate that is up to 1000 times larger than the solar wind mass-loss rate ($\dot{\mathrm{ M}}_\odot$). To investigate this dichotomy, we perform 3D hydrodynamics simulations of the stellar wind–planetary atmosphere interactions in the AU Mic system and predict the synthetic Ly α transits of AU Mic b. We systematically vary the stellar wind mass-loss rate from a ‘no wind’ scenario to up to a stellar wind with a mass-loss rate of $1000~\dot{\mathrm{ M}}_\odot$. We find that, as the stellar wind becomes stronger, the planetary evaporation rate decreases from 6.5 × 1010  g s−1 to half this value. With a stronger stellar wind, the atmosphere is forced to occupy a smaller volume, affecting transit signatures. Our predicted Ly α absorption drops from $\sim 20{{\ \rm per\ cent}}$ in the case of ‘no wind’ to barely any Ly α absorption in the extreme stellar wind scenario. Future Ly α transits could therefore place constraints not only on the evaporation rate of AU Mic b, but also on the mass-loss rate of its host star.