bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trace metal biogeochemical responses following wood ash addition in a northern hardwood forest
Authors: Deighton Holly D. , Watmough Shaun A. , Basiliko Nathan , Hazlett Paul W. , Reid Carolyn R. , Gorgolewski Adam 
Published: November 2020

Wood ash may be useful as a forest soil amendment in Canada, but trace metals can have detrimental effects if they accumulate in, or are transported from, forest ecosystems. Metal concentrations in soil water and sugar maple (Acer saccharum Marsh.) seedling tissue chemistry were measured in a north temperate hardwood forest over 4 years following a biomass boiler ash addition field trial. Twenty plots (3 m × 3 m) were established in Haliburton Forest with both fly and bottom ash treatments of 0, 4, and 8 Mg·ha−1 with four replicates, and tension lysimeters were positioned in each plot at 30, 50, and 100 cm depths. Over the 4 years, soil water metal concentrations in treated plots were not significantly different from those of the control plots. No differences in metal concentrations in foliage of sugar maple seedlings could be detected, but there were significantly higher concentrations of some metals (Al, Fe, Zn, Pb, Ni, and Sr) in roots of treated plots. Simulated drought mobilized several metals in upper mineral soil, but this mobilization occurred similarly in controls and ash-treated soils. These results suggest that doses below 8 Mg·ha−1 industrial wood ash with trace metal concentrations below Canadian regulatory limits do not cause an increase in trace metal mobility or availability in northern hardwood forests with acidic soils during the first 5 years after application.
Comparison and analysis of optical properties between vertical and inclined GaAs nanostructures
Authors: Sun Yan , Liu Lei , Lv Zhisheng , Zhangyang Xingyue , Lu Feifei , Tian Jian 
Published: November 2020

In this paper, COMSOL multi-physics field commercial software was used to design the simulation model of GaAs nanostructures array (vertical nanoholes, vertical nanowires, inclined nanoholes and inclined nanowires), and the changes of light absorption of these structures in the wavelength range of 200–840 nm were studied. The electric field distribution, carrier distribution and quantum efficiency of nanostructures are calculated and analyzed under certain structural parameters. The results show that the light absorption performance of nanowire structure in the short-wave region is better than that of the nanoholes structure. With a certain inclined angle, the inclined nanowire structure has a stronger light capture ability than the vertical nanowire structure, and the light absorption of nanowire structure has a minimum value at the 550 nm wavelength.
The Existence of Invariant Tori and Quasiperiodic Solutions of the Nosé–Hoover Oscillator
Authors: Niu Yanmin , Li Xiong 
Published: November 2020

In this paper, we consider an equivalent form of the Nosé–Hoover oscillator,

x

′

=
y
,

y

′

=
−
x
−
y
z
,

and

z

′

=

y

2

−
a

, where

a

is a positive real parameter. Under a series of transformations, it is transformed into a 2-dimensional reversible system about action-angle variables. By applying a version of twist theorem established by Liu and Song in 2004 for reversible mappings, we find infinitely many invariant tori whenever

a

is sufficiently small, which eventually turns out that the solutions starting on the invariant tori are quasiperiodic. The discussion about quasiperiodic solutions of such 3-dimensional system is relatively new.
An investigation of the measurement properties of the de Morton Mobility Index for measuring mobility capacity in hospital patients with Parkinson’s disease
Authors: Braun Tobias , Marks Detlef , Thiel Christian , Menig Alexandra , Grüneberg Christian 
Published: November 2020

Objective: To examine the measurement properties of the de Morton Mobility Index (DEMMI), a performance-based clinical outcome assessment of mobility capacity, in hospital patients with Parkinson’s disease. Design: Cross-sectional study. Participants: Hospital patients with Parkinson’s disease. Main outcome measure(s): Structural validity and unidimensionality (Rasch analysis), construct validity, internal consistency reliability, and inter-rater reliability of the de Morton Mobility Index (scale range: 0–100 points) were established. The minimal detectable change, the 95% limits of agreement and possible floor and ceiling effects were calculated to indicate interpretability. Results: We analysed validity ( n = 100; mean age: 70 years; 71% male) and reliability ( n = 47; mean age: 71 years; 68% male) in two samples. The mean Hoehn and Yahr stage was 3.2 and the mean disease duration was 12 years in both samples. Rasch analysis indicated unidimensionality with an overall fit to the model (chi-square = 21.49, P = 0.122). Seventy-three percent of hypotheses on construct validity were confirmed. Internal consistency reliability (Cronbach’s alpha = 0.91) and inter-rater reliability (intraclass correlation coefficient = 0.88; 95% confidence interval: 0.80 to 0.93) were sufficient. The minimal detectable change with 90% confidence was 17.5 points and the limits of agreement were 31%. No floor or ceiling effects were observed. The mean administration time was 6.6 minutes. Conclusion: This study provides evidence of unidimensionality, sufficient internal consistency reliability, inter-rater reliability, construct validity, and feasibility of the de Morton Mobility Index in hospital patients with Parkinson’s disease. Trial registration: German Clinical Trials Register (DRKS00004681). Registered May 6, 2013.
Evaluation and Comparison of Condylar Head Inclination With Respect to Glenoid Fossa in Cleft, Class III, and Class I Individuals
Authors: Khakhar Prutha Ganesh , Daigavane Pallavi , Kamble Ranjit , Niranjane Priyanka , Dargahwala Hamza , Bidwai Pooja 
Published: November 2020

Background: Cleft lip and palate are the most common congenital craniofacial defects, which need early intervention with a multidisciplinary approach including surgeons, orthodontists, speech therapists, pedodontists, etc. Craniofacial growth is affected the most, leading to marked skeletal discrepancies. Constricted maxillary arch is one of the reasons for faulty occlusal inclined planes which results in abnormal loading of condyles, thus leading to temporomandibular disorders (TMDs) in cleft. Condylar head inclination helps to evaluate the position of condyle in the glenoid fossa. Thus, changing the position of condylar head in the glenoid fossa at an early age prevents further worsening of TMD condition. The purpose of this study was to evaluate condylar inclination in individuals with cleft lip and palate and compare it with non-cleft individuals. Method: The study comprised of 40 subjects aged between 9 and 12 years, divided into 4 groups (10 in each)—unilateral cleft lip and palate (UCLP), bilateral cleft lip and palate (BCLP), and class III and class I malocclusion. Scanned three-dimensional digital volume tomography (3D-DVT) images were taken, and condylar head inclination was evaluated and compared. Result: Significant findings were obtained when group 1 was compared to group 2, group 3, and group 4 ( P-value = .001). Also, when group 2 was compared to group 3 and group 4, the values were statistically significant with P-value = .001. Conclusion: Condylar head inclination was found to be most anteriorly angulated in the class III group compared to all the other groups. Unilateral cleft lip and palate had more anteriorly angulated condyle than bilateral cleft lip and palate.
Patient and caregiver perspectives on burnout in peritoneal dialysis
Authors: Oveyssi Justin , Manera Karine E , Baumgart Amanda , Cho Yeoungjee , Forfang Derek , Saxena Anjali , Craig Jonathan C , Fung Samuel KS , Harris David , Johnson David W , Kerr Peter G , Lee Achilles , Ruiz Lorena , Tong Matthew , Wang Angela Yee-Moon , Yip Terence , Tong Allison , Shen Jenny I 
Published: November 2020

Background: Peritoneal dialysis (PD) can offer patients more autonomy and flexibility compared with in-center hemodialysis (HD). However, burnout – defined as mental, emotional, or physical exhaustion that leads to thoughts of discontinuing PD – is associated with an increased risk of transfer to HD. We aimed to describe the perspectives of burnout among patients on PD and their caregivers. Methods: In this focus group study, 81 patients and 45 caregivers participated in 14 focus groups from 9 dialysis units in Australia, Hong Kong, and the United States. Transcripts were analyzed thematically. Results: We identified two themes. Suffering an unrelenting responsibility contributed to burnout, as patients and caregivers felt overwhelmed by the daily regimen, perceived their life to be coming to a halt, tolerated the PD regimen for survival, and had to bear the burden and uncertainty of what to expect from PD alone. Adapting and building resilience against burnout encompassed establishing a new normal, drawing inspiration and support from family, relying on faith and hope for motivation, and finding meaning in other activities. Conclusions: For patients on PD and their caregivers, burnout was intensified by perceiving PD as an unrelenting, isolating responsibility that they had no choice but to endure, even if it held them back from doing other activities in life. More emphasis on developing strategies to adapt and build resilience could prevent or minimize burnout.
Infusion of anti-DFS70 antibodies prolonged survival of lupus-prone mice
Authors: Aljadeff Gali , Shemer Asaf , Katz Itai , Andrade Luis Eduardo C , Gilburd Boris , Halpert Gilad , Mahler Michael , Blank Miri , Amital Howard , Shoenfeld Yehuda 
Published: November 2020

Background Systemic-lupus-nephritis is a chronic autoimmune disease characterized by immune complex deposition and a flare of autoantibodies and leading to renal injury. Objectives To expose anti-Dense-Fine-Speckled-70 (DFS70)-antibodies to genetically-prone-lupus-mice. Methods NZBXW/F1 female mice were monitored for the onset of glomerulonephritis by proteinuria upon infusion of anti-DFS70 (40 μg/mouse), commercial-human-IgG (cIgG) or phosphate-buffered-saline (PBS) as controls. The survival time was detected by mice death. Circulating anti-dsDNA were tested by ELISA. Proteinuria, was defined by a standard semi-quantitative-Bayer-Multistix-dipstick. Kidney histology was analyzed by periodic-acid–Schiff-PAS staining. Results A significantly higher percentage of anti-DFS70-infused mice exhibited prolonged survival time as compared with cIgG and PBS-subjected mice (p < 0.022). One mouse out of 10 mice injected with anti-DFS70-antibodies died at week 36, whereas, 6 out of 10 mice subjected with PBS found dead at this time. Eighty percent of anti-DFS70 injected mice did not show severe glomerulonephritis by histology. Conclusions anti-DFS70 attenuated the progression of glomerulonephritis and prolonged the survival time. Circulating anti-DFS70-autoantibodies may confer a protective role against renal injury in murine-lupus-nephritis. Our data may propose a novel therapy approach for lupus patients.
Maximising the acceptability of extended time intervals between screens in the NHS Cervical Screening Programme: An online experimental study
Authors: Hill Emily , Nemec Martin , Marlow Laura , Sherman Susan Mary , Waller Jo 
Published: November 2020

Objective The NHS Cervical Screening Programme plans to increase the screening interval from 3 to 5 years for women aged 25–49 who test negative for human papillomavirus (HPV). This exploratory cross-sectional online survey tested the impact of different levels of information about the proposed change on acceptability of a longer interval. Methods Women aged 18–45 (n = 585) were individually randomised to one of three information exposure groups differing in the level of information provided about the screening interval change: (1) basic information; (2) basic information with additional detail about timeline of HPV infection; (3) as (2) but with the addition of a diagram. Acceptability of the change ( favourable and unfavourable attitudes) was assessed post-exposure alongside HPV timeline beliefs. We used ANOVA and regression analyses to test for between-group differences. Results Women in Group 3 had higher scores on the favourable attitudes sub-scale compared with Group 1. Women in Groups 2 and 3 had more accurate timeline beliefs than those in Group 1. There were no between-group differences in unfavourable attitudes. After adjusting for demographic factors, a higher favourable attitudes score was independently predicted by being in Group 3 compared to Group 1, more accurate HPV timeline beliefs, and previous irregular or non-attendance at screening. Conclusions Overall, acceptability of an increased screening interval was moderate, but providing women with information about the safety and rationale for this change may improve acceptability. In particular, communicating the long timeline from HPV exposure to cervical cancer may reassure women about the safety of the proposed changes.
Gilteritinib administration in a hemodialysis patient
Authors: Tollkuci Eris , Tran Tiffany , Myers Rebecca 
Published: November 2020

Introduction Gilteritinib is a multitargeted tyrosine kinase inhibitor (TKI) approved by the Food and Drug Administration (FDA) for acute myeloid leukemia (AML) with a FMS-related tyrosine kinase 3 (FLT3) mutation. The pharmacokinetics of gilteritinib in the setting of severe renal impairment (creatinine clearance [CrCl] 15-29 mL/min utilizing Cockcroft-Gault method) and end-stage renal disease are unknown. Gilteritinib is primarily metabolized by the liver through the CYP3A4 enzyme and is eliminated in both the feces and urine. Its excretion is primarily through the fecal route, accounting for 64.5% of the recovered dose. Only about 16.4% of the recovered dose has been detected in the urine of human subjects. Case Report We describe our patient case documenting the administration of gilteritinib in the setting of end-stage renal disease (ESRD) and hemodialysis (HD). Management and Outcomes: Our patient was initiated on single agent gilteritinib 120 mg by mouth once daily for relapse FLT3-TDK positive AML. Treatment course was complicated by pancytopenia, neutropenic fever, and staphylococcus lugdunensis bacteremia requiring temporary interruption of therapy. Discussion Given that gilteritinib is metabolized by the liver and eliminated primarily in the feces, one does not expect an increase in toxicity related to impaired renal function. Although this report describes the successful utilization of gilteritinib, caution should be exercised when administering in patient populations with end organ disease, and patient comorbidities should be taken into account.
Clinical characteristics and outcomes of 85 intensive care patients with Covid-19 in South London: A single centre observational study
Authors: Isted Alexander , McDonnell Angus J , Jones Eben , Grundy Tomas , Jeyabraba Swarna , Ali Tariq O , Khorasanee Reza , Bhalla Aditya , Shurovi Badrun , Rowland Katie , Sykes Richard , Yoon Soo , Morillon Paul , Vijayakumar Rohini Salvadi , Clarke Jayson , Cox Charlie , Breeze Richard , Khaliq Waqas 
Published: November 2020

Background In March 2020, Covid-19 secondary to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was declared a global pandemic. Methods This retrospective observational study included patients with Covid-19, managed in a single intensive care unit (ICU). We collected data on patient characteristics, laboratory and radiological findings and ICU management. Data are reported as median (interquartile range). Binary logistic regression modelling was used to identify variables at ICU admission associated with mortality. Results 85 patients (age 57.3 years [49.4–64.2], 75.3% male) were followed up for 34 days (26–40). The commonest comorbidities were hypertension (51.8%), obesity (48.7%), and type 2 diabetes (31.8%). Covid-19 presented with shortness of breath (89.4%), fever (82.4%), and cough (81.2%), first noted 8 days (6–10) prior to ICU admission. PaO2/FiO2-ratios at ICU admission were 8.28 kPa (7.04–11.7). Bilateral infiltrates on chest X-ray, lymphopenia, and raised C-reactive protein and ferritin were typical. 81.2% received invasive mechanical ventilation (IMV). Acute kidney injury occurred in 62.4% with renal replacement therapy required in 20.0%. By the end of the follow-up period, 44.7% had died, 30.6% had been discharged from hospital, 14.1% had been discharged from ICU but remained in hospital and 10.6% remained in ICU. ICU length of stay was 14 days (9–23). Age was the only variable at admission which was associated with mortality. PaO2/FiO2-ratio, driving pressure and peak ferritin and neutrophil count over the first 72-hours of IMV all correlated with mortality. Conclusions We report the clinical characteristics, ICU practices and outcomes of a South London cohort with Covid-19, and have identified factors which correlate with mortality. By sharing our insight, we hope to further understanding of this novel disease.
The effects of interactive E-learning on delirium recognition ability and delirium-related strain of care among critical care nurses
Authors: Najafi Ghezeljeh Tahereh , Rahnamaei Fatemeh , Omrani Soghra , Haghani Shima 
Published: November 2020

Background Nursing care for patients with delirium is very complex and stressful and is associated with considerable care strain for nurses. Delirium recognition is the first step to the prevention and management of delirium and reduction of strain of care. Education is one of the strategies for improving nurses’ delirium recognition ability. Objectives This study aimed to evaluate the effects of interactive E-learning on delirium recognition ability and delirium-related strain of care among critical care nurses. Methods This quasi-experimental study was conducted in 2019 using a two-group pretest-posttest design. Participants were 98 critical care nurses recruited through a census from two hospitals in Iran. They were non-randomly allocated to an intervention and a control group. Study intervention was an interactive E-learning program with four parts on delirium, its prevention, its treatment, and its diagnostic and screening procedures. The program was uploaded on a website and its link was provided to participants in the intervention group. Before and two months after the intervention, data were collected using the Strain of Care for Delirium Index and five case vignettes. For data analysis, the Chi-square, Fisher’s exact, independent-sample t, and paired-sample t tests were performed usingthe SPSS software (v. 16.0). Findings Groups did not significantly differ from each other regarding the pretest mean scores of delirium recognition ability and strain of care. After the intervention, the mean score of delirium recognition ability in the intervention group was significantly greater and the mean score of strain of care was significantly lower than the control group (P < 0.05). Conclusion Interactive E-learning is effective in significantly improving critical care nurses’ delirium recognition ability and reducing their strain of care. As nurses’ heavy workload and limited free time are among the main barriers to their participation in face-to-face educational programs, interactive E-learning can be used for in-service education.
Surgery as Single-Modality Treatment for Early-Stage Olfactory Neuroblastoma: An Institutional Experience, Systematic Review and Meta-analysis
Authors: Meerwein Christian M. , Nikolaou Georgios , H. A. Binz Gregori , Soyka Michael B. , Holzmann David 
Published: November 2020

Background For olfactory neuroblastoma (ONB), the combination of surgical tumor resection and radiation therapy (RT) has been considered the “gold standard” in treatment protocols intended to cure. Objective To summarize evidence on the treatment of ONB using surgery alone. Methods A retrospective institutional case series, a systematic review of the literature, and an individual patient data (IPD) meta-analysis on only surgically treated ONB patients. Results At our institution, a total of 10 patients were treated through surgery alone and remained alive and free of disease at last follow-up. The IPD meta-analysis on 128 patients revealed a disease-free survival (DFS) and overall survival (OS) of 67.7% and 75.4% at 5 years and 57.1% and 71.9% at 10 years, respectively. Univariate analysis showed that Kadish stage C/D and Hyams grading III//IV significantly affected OS (P = 0.000 and P = 0.000) and DFS (P = 0.000 and P = 0.002). For low-risk patients, the DFS was 80.6% at 5 years and 67.8% at 10 years, respectively. Conclusions Surgery alone is an equivalent alternative to combined treatment in carefully selected low-risk ONB patients with better outcome measures than previously reported.
The relationship between coronary slow flow phenomenon and carotid femoral pulse wave velocity and aortic elastic properties
Authors: Akkaya Hasan , Güntürk Ertuğrul Emre 
Published: November 2020

Introduction In this study, we aimed to investigate the relationship between coronary slow flow (CSF) and carotid-femoral pulse wave velocity (CFPWV). Methods 78 (27 women, mean age 43.95 ± 7.28) patients with CSF, and 70 (22 women, mean age 44.34 ± 7.08) healthy individuals were included in the study. Arterial stiffness measurement was performed to both groups via CFPWV, which is considered the gold standard. Aortic elastic properties (ASI-β and aortic distensibility) were evaluated in both groups. Results The CSF group had significantly higher CFPWV and aortic distensibility values and significantly lower ASI-β values compared to the control group. There was a positive correlation between TIMI frame count (TFC) obtained in all coronary arteries and CFPWV and aortic distensibility, and a negative correlation between TFC and ASI-β. It was determined that CFPWV predicted CSF with 97% specificity and 98% sensitivity at a 7.68 cut-off value (ROC area = 994, p < 0.001). ASI-β was determined to predict CSF with 64% specificity and 47% sensitivity at a 2.98 cut-off value (ROC area = 047, p < 0.001). Aortic distensibility was determined to predict CSF with 76% specificity and 79% sensitivity at a 3.94 cut-off value (ROC area = 706, p < 0.001). Conclusion Arterial stiffness increases in CSF patients, suggesting that CSF is a systemic pathology rather than a local disease and that a systemic cause such as atherosclerosis plays a role in etiology.