bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Vitro Anticancer Effects of Stilbene Derivatives: Mechanistic Studies on HeLa and MCF-7 Cells
Authors: Rashid Faisal , Saeed Aamer , Iqbal Jamshed 
Published: August 2020

Background and Objective:
The growing prevalence of cancer and the resulting chemoresistance exert not only
a great healthcare burden but is also a great challenge to public health, worldwide. In search of new chemical entities
against cancer, triazine hybrids of stilbene scaffold were investigated for their anticancer potential.

Materials and Methods:
Synthetic triazine hybrids of stilbene were used for determination of their anticancer potential for
cervical (HeLa) and breast (MCF-7) carcinoma cells. Hit compound (7e) namely, sodium (E)-6,6'-(ethene-1,2-diyl)bis(3-
((4-chloro-6-((3-luorophenyl)amino)-1,3,5-triazin-2-yl)amino)benzenesulfonate) was explored further for mechanistic
studies.

Results:
In a set comprised of twelve derivatives, compound, sodium (E)-6,6'-(ethene-1,2-diyl)bis(3-((4-chloro-6-((3-
luorophenyl)amino)-1,3,5-triazin-2-yl)amino)benzenesulfonate) (7e) was found most active against HeLa and MCF-7
cells. The present study has revealed that compound 7e may activate mitochondrial pathway of apoptosis in HeLa and
MCF-7 cells which was assessed by DNA binding studies, estimation of release of Lactate Dehydrogenase (LDH),
fluorescence imaging, production of Reactive Oxygen Species (ROS) in cancer cells, analysis of cell cycle by flow
cytometry, change in Mitochondrial Membrane Potential (MMP) and activation of caspase-9 and caspase-3, respectively.

Conclusion:
Compound 7e may serve as a lead in designing new anticancer compounds from stilbene scaffold.
Antibiotic Loaded Nano Rod Bone Cement for the Treatment of Osteomyelitis
Authors: Rajendran Mala , Iraivan Gazana , Ghayathri B.L.  , Mohan Preetha , Chandran Keerthana R. , Nagaiah Hari P. , Selvaraj Ruby C.A. 
Published: August 2020

Background:
Polymethyl Methacrylate (PMMA) bone cement is the clinical gold standard
biomaterial for local antibiotic therapy in osteomyelitis. However, it releases 50% of the antibiotic
within the first three days. It generates excessive heat during polymerization and is non-biodegradable.
It must be removed by another operation. The best-known alternative for PMMA is hydroxyapatite.

Objective:
The present patented work is focused on synthesizing the biodegradable hydroxyapatite in
nano form for slow and sustained release of antibiotics and studying the release kinetics of antibiotics.

Method:
Nano-hydroxyapatite was synthesized by co-precipitation method and characterized by particle
size analyser, transmission electron microscopy, fourier transform infrared spectroscopy and energy
dispersive X-Ray analysis. Antibiotic loaded nano-hydroxyapatite was prepared as 7 mm beads.
The efficiency of drug-loaded nano-hydroxyapatite beads against osteomyelitic isolates was evaluated
by well diffusion assay. Zero-order, first order, second order, Higuchi model, Korsmeyer-Peppas and
Gompertz models were fit into the release kinetics of antibiotics from hydroxyapatite.

Results:
Average size of nano-hydroxyapatite was 5 nm. The bactericidal activity exhibited by antibiotic-
loaded micro-sized hydroxyapatite was therapeutic until 10 days only, whereas antibiotic-loaded
nano-hydroxyapatite was therapeutic until 8 weeks. This confirms the burst release of antibiotics from
micro-sized hydroxyapatite beads. In contrast, the release was slow and sustained up to 8 weeks from
nano-hydroxyapatite. Korsmeyer-Peppas model fits into the release kinetics of antibiotics from nanohydroxyapatite.

Conclusion:
Nano-hydroxyapatite with Ca/P ratio of 1.78 is suitable for the slow and sustained delivery of antibiotics for
8 weeks.
Φιλαργυρία – czy jedyny korzeń wszelkiego zła?
Authors: Tomczyk Dominik 
Published: August 2020

Autor artykułu przedstawia analizę fragmentu 1 Listu do Tymoteusza 6, 10a i odpowiada na podstawowe pytanie, czy miłość pieniędzy (φιλαργυρία) jest rzeczywiście jedynym korzeniem wszelkiego zła? Autor analizuje relację Pawła Apostoła do filozofii stoików w kontekście określenia αὐτάρκεια. Następnie przedstawia słowo φιλαργυρία od strony semantycznej. Omawia po kolei kluczowe słowa tekstu: „korzeń” (ῥίζα), „wszelkie zło” (πάντον τῶν κακῶν) oraz „miłość pieniędzy” (φιλαργυρία). Brak rodzajnika określonego (ἡ) przy słowie „korzeń” (ῥίζα) sprawia, że należy traktować je jakościowo. Tym samym ῥίζα γὰρ πάντων τῶν κακῶν ἐστιν ἡ φιλαργυρία należy rozumieć następująco: (u)miłowanie pieniędzy nie jest jedynym korzeniem wszelkiego zła, ale jednym z wielu innych.
Applying and Extending the FITT Framework to Identify the Challenges and Opportunities of Successful eHealth Services for Patient Self-Management: Qualitative Interview Study
Authors: Kujala Sari , Ammenwerth Elske , Kolanen Heta , Ervast Minna 
Published: August 2020

Background
The number of public eHealth services that support patient self-management is rapidly increasing. However, the implementation of these eHealth services for self-management has encountered challenges.

Objective
The purpose of this paper was to analyze the challenges and opportunities of implementing eHealth services for self-management by focusing on the fit between the technical solution and clinical use.

Methods
We performed in-depth interviews with 10 clinical project coordinators and managers who were responsible for developing and implementing various eHealth services for self-management interventions in five university hospitals in Finland. The results were analyzed using content analysis and open coding. The Fit between Individuals, Task, and Technology (FITT) framework was used to interpret the findings.

Results
The implementation of self-management services involved many challenges related to technical problems, health professional acceptance, patient motivation, and health organization and management. The implementers identified practices to manage the identified challenges, including improving the design of the technology, supporting health professionals in the adoption of the eHealth services, changing the work processes and tasks, involving patients, and collectively planning the implementation inside an organization. The findings could be mostly attributed to the dimensions of the FITT framework.

Conclusions
The FITT framework helped to analyze the challenges related to the implementation, and most of them were related to poor fit. The importance of patients as stakeholders in eHealth services for patient self-management needs to be highlighted. Thus, we propose that patients should be added as a different type of individual dimension to the FITT framework. In addition, the framework could be extended to include organization and management in a new context dimension.
Role of Assistive Robots in the Care of Older People: Survey Study Among Medical and Nursing Students
Authors: Łukasik Sylwia , Tobis Sławomir , Kropińska Sylwia , Suwalska Aleksandra 
Published: August 2020

Background
Populations are aging at an alarming rate in many countries around the world. There has been not only a decrease in the number of births and an increase in the percentage of older people, but also an increase in the number of people living alone. There is growing demand for specialist medical care and daily care with the number of people who can act as caregivers reducing. The use of assistive robots can, at least partially, solve these problems.

Objective
The purpose of this study was to examine the opinions of future health care professionals (medical and nursing students) regarding the use of assistive robots in the care of older people.

Methods
The study was conducted with a group of 178 students from Poznan University of Medical Sciences, Poznań, Poland (110 nursing students and 68 medical students), using the Users’ Needs, Requirements, and Abilities Questionnaire.

Results
The participants of this study believed that assistive robots should, first of all, remind older people to take medication regularly, ensure their safety, monitor their health status and environment, provide cognitive training, and encourage them to maintain physical activity. In the students’ opinion, the robot should not be an older person’s companion but only act as an assistant. Nursing students had significantly higher scores than medical students in several statements concerning everyday use of robots, including reminding about meals (P=.03), monitoring the environment (P=.001), providing advice about a healthy diet (P=.04), monitoring the intake of food and fluids (P=.02), and automatic “switch on” function (P=.02). Nursing students were more focused on the social functions of robots, including encouraging contact with friends (P=.003) and reducing the sense of loneliness and improving mood (P=.008). Medical students were more aware of privacy issues in the statement concerning the possibility of switching off the robot in specific situations (P=.01).

Conclusions
Our study revealed a generally positive attitude of future doctors and nurses toward assistive robots, which can have an impact on their acceptance by older adults. In the future, medical professionals could help their patients to choose the right robots (and necessary functions) that are best suited to their needs. However, this would require expanding the curriculum to include the issues of gerontechnology.
Inter-Organisational Coordination Work in Digital Curation: the Case of Eurobarometer
Authors: Eschenfelder Kristin , Shankar Kalpana 
Published: August 2020

Open research is predicated upon seamless access to curated research data. Major national and European funding schemes, such as Horizon Europe, strongly encourage or require publicly funded data to be FAIR - that is, Findable, Accessible, Interoperable, Reusable (Wilkinson, 2016). What underpins such initiatives are the many data organizations and repositories working with their stakeholders and each other to establish policies and practices, implement them, and do the curatorial work to increase the available, discoverability, and accessibility of high quality research data. However, such work has often been invisible and underfunded, necessitating creative and collaborative solutions.
In this paper, we briefly describe how one such case from social science data: the processing of the Eurobarometer data set. Using content analysis of administrative documents and interviews, we detail how European data archives managed the tensions of curatorial work across borders and jurisdictions from the 1970s to the mid-2000s, the challenges that they faced in distributing work, and the solutions they found. In particular, we look at the interactions of the Council of European Social Science Data Archives (CESSDA) and social science data organizations (DO) like UKDA, ICPSR, and GESIS and the institutional and organizational collaborations that made Eurobarometer â€œtoo big to failâ€. We describe some of the invisible work that they underwent in the past in making data in Europe findable, accessible, interoperable, and conclude with implications for â€œfrictionlessâ€ data access and reuse today.
Educación a distancia y mundos virtuales
Authors: García Sánchez Jaime , Jáuregui Arias Patricia 
Published: August 2020

La educación a distancia ha recorrido un camino largo desde su primera aparición hasta nuestros días. No siempre bien reconocida y casi siempre mal evaluada desde la perspectiva de la educación tradicional presencial, la educación a distancia en su fase virtual ha logrado tener un espacio propio de desarrollo y aceptación.
La adopción y utilización creativa de los avances en los distintos medios de comunicación para fines educativos, y de transmisión y recepción de información, ha puesto a esta modalidad educativa en un punto de vanguardia respecto a los modelos tradicionales. El uso de la red de Internet y los adelantos que en ella y de ella se desprenden hacen ver que la educación a distancia tendrá un papel cada vez más relevante en la sociedad global, revolucionando los esquemas del aprendizaje humano mediante su operatividad en mundos interactivos y tridimensionales (realidad virtual y aumentada), que generarán una nueva manera de abordar el aprendizaje humano y de entender la escuela.
Development of comparable algorithms to measure primary care indicators using administrative health data across three Canadian provinces
Authors: Alsabbagh Mhd. Wasem , Kueper Jacqueline Kathleen , Wong Sabrina T , Burge Frederick , Johnston Sharon , Peterson Sandra , Lawson Beverley , Chung Hannah , Bennett Mark , Blackman Stephanie , McGrail Kimberlyn , Glazier Richard , Campbell John , Hogg William 
Published: August 2020

Introduction
Across the world, data sources to support learning in primary care (PC) lag far behind that of acute care. Having comparable data sources across jurisdictions is essential for scaling and spreading healthcare learnings.
Objectives
The purpose of this work was to 1) identify and develop indicators of PC performance using administrative data and 2) examine the comparability of indicator definitions across three Canadian provinces (Nova Scotia, Ontario, British Columbia). This work is valuable for demonstrating how to arrive at comparable administrative data indicators across jurisdictions with different care patterns.
Methods
The TRANSFORMATION study is a multi-province Canadian study of PC that aims to improve PC performance measurement reporting. We initially compiled a list of PC performance indicators that had been used with existing administrative data. We followed and documented an iterative process to achieve comparable indicator operationalizations across the three provinces in Canada.
Results
Our final list included 21 PC performance indicators pertaining to 1) technical care (n=4), 2) continuity of care (n=6), and 3) health services utilization (n=11). Establishing comparability between these PC performance indicators was possible. The main challenge was major differences in data characteristics and available resources including pre-existing algorithms used in each province to define the indicators. We present examples of these differences including the identification of patients with diabetes and of bone mineral density measurement.
Conclusion
Arriving at comparable definitions of PC performance indicators using administrative data is challenging and time-consuming, but possible — even without data pooling. Through an iterative and well-documented process, research teams and policy-makers can develop and establish comparability of PC performance indicators that can help in supporting continuous improvements in healthcare system performance. More work is necessary to standardize approaches and optimize the comparability of PC performance indicators across jurisdictions.
Pengembangan Model Agroeduwisata sebagai Implementasi Pertanian Berkelanjutan
Authors: Novikarumsari Nurul Dwi , Amanah Siti 
Published: August 2020

Dimensi sosial, lingkungan alam dan manusia merupakan aspek utama dalam pertanian berkelanjutan. Aspek lingkungan alam disediakan oleh kawan dan manusia mencakup subyek/pihak-pihak terkait memberikan peluang bagi pengembangan agroeduwisata sebagai salah satu upaya peningkatan ekonomi masyarakat. Penelitian ini bertujuan untuk menganalisis kebutuhan petani terkait penyuluhan dan menyusun model pengembangan agroeduwisata di lokasi penelitian. Penelitian ini dilaksanakan di empat wilayah Kota/Kabupaten Bogor, yaitu Kelurahan Cimahpar, Kelurahan Situgede, Desa Benteng dan Desa Purwasari. Penelitian ini menggunakan metode mix methods, data kuantitatif diperoleh dari 201 petani yang dipilih secara acak dan data kualitatif melalui Focus Group Discussion (FGD) dan wawancara mendalam. Hasil penelitian menunjukkan bahwa: 1) mayoritas petani (34,3%) membutuhkan penyuluhan terkait budidaya, dan 2) setiap lokasi memiliki strategi model agroeduwisata bisa diterapkan di lokasi penelitian dengan pelibatan berbagai pihak (kelompok wanita tani, gabungan kelompok tani, dan kelompok lainnya).
Eliminating the Board of Pharmacy’s Role in Designating a Pharmacist-in-Charge
Authors: Adams Alex 
Published: August 2020

Nearly all states require that each licensed pharmacy designate a pharmacist-in-charge (PIC). By law, the PIC typically has responsibility for all professional practice laws and facility standards laws and can be held accountable for such. However, the extent to which the PIC has actual authority over many facility standards varies by organization. This can seemingly put a target on the back of the PIC for decisions they wield little authority over. Idaho recently removed the legal references to the PIC, signaling that facilities are responsible for facility standards and insulating pharmacists from discipline for matters that are outside their control.

Letter
التدابير الصحية في مواجهة جائحة كورونا (COVID-19) في المملكة العربية السعودية
Authors: Bin Mohamed Alhakawi Ahmed , Bin Zafir Alshihri Mohamed , Mohamed Hamed Elneil Osman 
Published: August 2020

توثق هذه الورقة تجربة المملكة في كيفية تعاملها مع جائحة كورونا (COVID-19) والتجهيزات السابقة للجائحة، والعوامل التي ساعدت المملكة في التعامل معها. وقد تم مراجعة التدابير الاحترازية الموجودة أصلًا للتعامل مع الأمراض المعدية عامة قبل الجائحة والاستعدادات التي تقوم بها وزارة الصحة، بالإضافة إلى الاستعدادات الخاصة تجاه للجائحة، ثم كيف تعاملت الوزارة أثناء حدوث الجائحة، وتحليل ذلك مستخدمين حسابات التوقعات (Projection) في الأوبئة. بتقدير عدد الأشخاص الذين يمكن أن يصابوا من حالة واحدة تسمى (R0) دون أي تدخل. كما أن المؤشرات التي تم القياس بها هي معدل الوفيات ومعدل الإصابة وتم مقارنته مع المؤشرات في بعض الدول المختلفة إقليمية وعالمية، كما تمت الإشارة إلى الإجراءات التفصيلية التي اتخذتها وزارة الصحة والإجراءات التي تمت على المستوى الوطني عامة.
ومن أبرز نتائج الإجراءات الاحترازية إبطاء التفشي والتقليل بقدر الإمكان من الأعداد المصابة للحيلولة دون حدوث شلل في الخدمات الصحية المقدمة، وتشير المؤشرات إلى أن المملكة تعتبر من أوائل الدول في معدل الوفيات المنخفض. وقد كانت على أهبة الاستعداد لهذه الجائحة، وتمكنت من عبور أصعب المراحل دون الدخول في هلع في التعامل مع هذه الجائحة، كما كانت هناك خطط سابقة للجائحة؛ إذ إن هناك نظامًا صحيًّا قويًّا وقاعدة مستشفيات، وكذلك عوامل مساعدة كثيرة مثل: الدعم الحكومي اللامحدود للقطاع الصحي، والتعاون الوثيق بين أجهزة الدولة، وتفهم المواطنين للوضع الحرج الذي مرت به المملكة ودول العالم أجمع. وقد نجحت المملكة في إبطاء تفشي الجائحة؛ مما قلل من الخسائر البشرية مقارنة بالدول الأخرى.
مهددات الصحة النفسية المرتبطة بالحجر المنزلي إثر فيروس كورونا المستجد (COVID-19)
Authors: Salem Mohsen Alasmari Saed 
Published: August 2020

لقد تركت جائحة كورونا ـ ولا تزال ـ آثارها الصحية والاقتصادية والاجتماعية والنفسية على العالم أجمع بطريقة كبيرة؛ ما تسبب في شلل وتعطيل مفاصل حياة الناس، ونتجت عنها مهددات وآثار نفسية ناجمة عن اضطرار الناس للحجر المنزلي وعدم قدرتهم على الخروج إلا للضرورة، ومن أهم هذه المهددات القيود المفروضة على أفراد الأسرة وانعكاساتها النفسية، والتباعد الاجتماعي في التعامل اليومي بين الأفراد بما يتعارض مع التواصل الذي يعتبر عملية اجتماعية مهمة في حياة الإنسان، وتشابه ظروف الحجر المنزلي بظروف العقوبات السالبة للحرية، وتغير نمط الحياة الاقتصادية، وانتشار الشائعات والتأثير السلبي لوسائل الإعلام، والقلق بشأن توفير الاحتياجات المنزلية، والضغط النفسي على كبار السن وغيرها، وللحجر المنزلي تأثيراته وانعكاساته على السلوك النفسي الشخصي للناس، كما تشير النظريات المفسّرة للضغوط النفسية والاجتماعية، ومن ذلك رهاب العزلة والأمراض النفسية، والخوف وزيادة الشك في صحة المعلومات وتأثيره، واضطرابات الأكل، والعدوانية.
ويتلخص العلاج الفردي للآثار النفسية الناتجة عن الحجر المنزلي في التهيئة النفسية للتعامل مع الأزمة، والحرص على الطاعات وزيادة فترات العبادة لله تعالى، والتكيف والـتأقلم الاجتماعي مع ظروف الحجر المنزلي، وتعزيز العلاقة الإيجابية مع الزوجة والأبناء، والتواصل الإلكتروني والأنشطة الاجتماعية، والأكل الجيد المتوازن، وقد أوصت الدراسة بضرورة الوعي بأهمية الصحة النفسية ومدى تأثيرها على حياة الإنسان، وإدراك مفهوم الوعي الذاتي النفسي وأهميته، وزيادة المعرفة عن كل ما يمكن أن يهدد الصحة النفسية، وعقد دورات متخصصة في الثقافة النفسية لجميع فئات المجتمع.
LITERATURE IN PAINTING / PAINTING IN LITERATURE
Authors: Joshi Shobhana 
Published: August 2020

English : The world is pictorial, it is also a movie. "Who is this painter"! Do not know! But a small part of the universe is born in the middle of these pictures and movies, it is time-consuming. One watches these movies during the movement of breaths and stops. This which he sees, passes through the camera of his eyes and is printed in the mind and heart. He is restless. Let me share that print. A hieroglyph of this sharing from the rest. The script rang, the pictures were painted, the colors were unrefined. Manas became fertile, art enriched by imagination. Art grew to vibrancy from the sentiments of human beings progressed by primitive barbarism. The infinite beauty of the parallel vision of creation embodied dance art, singing art with Prabhavishnuta. The instruments were unmodified. When the replica of nature was found to be a sound form, the concrete shape from the soil and stone was found in the form of "sculpture".
Hindi : सृष्टि चित्रलिखित सी है, चलचित्र भी है। ''ये कौन चित्रकार है''! पता नहीं! पर सृष्टि का एक क्षुद्र हिस्सा भर मनुष्य इन चित्रों-चलचित्रों के बीच ही जनमता है, काल-कवलित होता है। सांसों के आने-जाने और रूक जाने की अवधि में इन चलचित्रों को देखता है। यह जो वह देखता है, उसकी आँखों के कैमरे से गुजरकर दिल-दिमाग में छपता है। उसे बैचेनी होती है। उस छपे को साझा करूँ। इस साझा करने की बैचेनी से जनमी चित्रलिपि। लिपि की बेल फैली, चित्र रचे चितेरों ने, रंग अविष्कृत हुए। मानस उर्वर हुआ, कल्पना से कला समृद्ध हुई। आदिम बर्बरता से आगे बढ़े मनुष्य के भावों से कला को स्पन्दन मिला। सृष्टि के समानांतर दृष्टि के अपरिमित सौंदर्य ने प्रभविष्णुता के साथ नृत्य कला, गायन कला को मूर्त्त किया। वाद्य अविष्कृत हुए। प्रकृति की प्रतिकृति ध्वनि रूप पा गयी तो मिट्‌टी और पत्थर से ठोस आकार ''मूर्तिकला'' रूप में मिला।
INTERCONNECTION OF FINE ARTS AND JUGALBANDI OF POETRY
Authors: Shukla Annapurna 
Published: August 2020

English : Nature itself is a poisonous plank. This wonderful combination is not only an epic, but also a great visual picture. There are poetic juices, verses and ornaments in it, there is also a variety of colors and forms, only then the poem is a sparkling image and the picture is a sparkling living poem. The feeling of both is counted towards the end. All arts are similar at the cognition level and are expressed and divided in the mediums, irrespective of the artist.
Elemental analysis of the arts shows that the interrelationships of all the fine arts are very deep and have always influenced and enriched each other. If the meaning of words is intensified, then the lines have their elegance, if the notes have their own universe, the postures have their own sense of the world, if the stones have a lyrical form, then the images have their own shape. Painting in the arts has developed parallel to poetry. According to the medium, all fine arts have their own existence. To express himself in the early period, these arts were his gross languages. Even after their establishment, man must have been searching for such a powerful medium for years. By which one could express his entire thought. He must have got the word as a result of that.
Hindi : प्रकृति स्वयं एक विषाल फलक है। यही अद्भुत संयोजन एक महाकाव्य तो है ही, एक विराट दृश्य चित्र भी है। इसमें काव्य के रस, छन्द और अलंकार है तो विविध रंग और रूपाकार भी हंै तभी तो कविता एक जगमगाता बिम्ब है तो चित्र एक जगमगाती सजीव कविता। दोनों की अनुभूति अन्तस में गुनी जाती है। सभी कलाएं अनुभूति स्तर पर समान होतीं है और माध्यमों में व्यक्त होकर विभक्त हो जातीं है फिर चाहे कलाकार कहीं का हो।
कलाओं के तात्विक विश्लेषण से पता चलता है कि सभी ललित कलाओं के अन्तःसम्बन्ध बहुत गहरे हैं और ये सदैव एक दूसरे को प्रभावित और सम्पन्न करते रहें हैं। यदि षब्दों के अर्थ की गहनता है , तो रेखाओं का अपना लालित्य है, यदि सुरों का अपना ब्रह्मांड है तो मुद्राओं का अपना भाव लोक है, यदि पत्थरों का एक लयात्मक स्वरूप है तो बिम्बों का अपना एक आकार बोध है। कलाओं में चित्रकला तो काव्य के समानान्तर ही विकसित हुई है। माध्यम के अनुसार सभी ललित कलाओं का अपना-अपना अस्तित्त्व है। आदि काल में अपने को व्यक्त करने के लिए यहीं कलाएं उसकी स्थूल भाषाएं थी। इनकी स्थापना के बाद भी मनुष्य वर्षों ऐसे शक्तिशाली माध्यम की खोज में लगा रहा होगा। जिसके द्वारा वह एक अपने सम्पूर्ण चिन्तन को व्यक्त कर सकता था। उसी के परिणाम स्वरूप उसे शब्द मिला होगा।