bluuebunny/crossref_metadata_2025_split huggingface dataset:
Portable cardiac self-stress test device development based on metabolic equivalent (MET)
Authors: Samad Whomaira binti Abdul , Othman Mohd Afzan bin , Safri Norlaili binti Mat , Razak Mohd Azhar bin Abdul 
Published: March 2020

<span>Cardiovascular disease (CVD) is the main cause of death worldwide and the type varies depending on symptom and causes. There are several procedures to determine the type of CVD such as blood test, holter monitoring, cardiac stress test and many more. Cardiac stress test is a procedure to exert pressure on the heart by doing physical activities to determine heart functionality and abnormal heart activity. It is done to gather information on heart condition supported by evidence in the form of electrocardiogram (ECG) signal. However, patients with heart problem will have to take turns to run the test due to limited access to the equipment especially in government hospital. Therefore, this paper proposed the development of cardiac self-stress test device to provide a pre-diagnosis result based on metabolic equivalent (MET) value. The device named “i-STress device” is a stand-alone device integrating the use of software application and hardware. The software was built by using MIT App Inventor 2 and the hardware built based on Arduino 101 and Sparkfun Heart Monitor AD 8232 and the test result saved in SD card. The device will be useful to sort out patient’s case priority </span><span>as well as providing pre-diagnosis result before conducting a real cardiac stress test.</span>
Wideband frequency reconfigurable metamaterial antenna employing SRR and CSRR for WLAN application
Authors: Y. Iliyasu Adamu , Bin Hamid Mohamad Rijal , A Rahim Mohamad Kamal , Bin Mohd Yusoff Mohd Fairus 
Published: March 2020

This paper presents the design of Wideband Frequency Reconfigurable Metamaterial Antenna by Employing Split Ring Resonator (SRR) and Complementary Split Ring Resonator (CSRR) for Wireles Area Network (WLAN) Apllication. The design is based on reconfiguring wideband metamaterial antenna by applying frequency reconfiguration technique. This was achieved by employing SRR and CSRR for bandwidth enhacement and two PIN Diode switches at different position for reconfiguration. The antenna has electrical dimention of at 2.4 GHz. Computer Simulation Technology (CST) Software was used to determine the effectiveness of the technique. This design has several advantages like wider bandwidth which cover 2.4 GHz and 5.2 GHz WLAN bands, with three different single bands. From the simulation results, it was found that, the antenna has a bandwidth which covered 2.4 to 5.6 GHz, single bands at 2.5 GHz, 3.0 GHz and 3.5 GHz, with realized peak gain of 2.24 dBi and 3.9 dBi at 2.4 GHz and 5.2 GHz respectively and average efficiency of 96%. The antenna can be used for wireless application and cognitive radio application.
A novel intelligent model for classify and evaluating non-functional security requirements form scenarios
Authors: AbdelQader Akram AbdelKarim 
Published: March 2020

Software requirements with its functional and non-functional methods are the first important phase in producing a software system with free errors. The functional requirements are the visual actions that may easily evaluated from the developer and from the user, but non-functional requirements are not visual and need a lot of efforts to be evaluated. One of the main important non-functional requirements is security, which focuses on generating secure systems from strangers. Evaluating the security of the system in earlier steps will help to reduce the efforts of reveals critical system threats. Security threats found because of leaking of security scenarios in requirement phase. In this paper, we purpose an intelligent model to extract and evaluate security features from scenarios based on set of security system goals and a set of security requirements saved on rich story scenarios dataset (RSSD). This model will used a support vector machine (SVM) classifier to classify the security requirement based on RSS dataset. The using of SVM will enhance the overall process of evaluating the security requirements. The results show a significant enhancement in security improvements.
Non-dominated sorting Harris’s hawk multi-objective optimizer based on reference point approach
Authors: Yasear Shaymah Akram , Ku-Mahamud Ku Ruhana 
Published: March 2020

A non-dominated sorting Harris’s hawk multi-objective optimizer (NDSHHMO) algorithm is presented in this paper. The algorithm is able to improve the population diversity, convergence of non-dominated solutions toward the Pareto front, and prevent the population from trapping into local optimal. This was achieved by integrating fast non-dominated sorting with the original Harris’s hawk multi-objective optimizer (HHMO). Non-dominated sorting divides the objective space into levels based on fitness values and then selects non-dominated solutions to produce the next generation of hawks. A set of well-known multi-objective optimization problems has been used to evaluate the performance of the proposed NDSHHMO algorithm. The results of the NDSHHMO algorithm were verified against the results of an HHMO algorithm. Experimental results demonstrate the efficiency of the proposed NDSHHMO algorithm in terms of enhancing the ability of convergence toward the Pareto front and significantly improve the search ability of the HHMO.
Flower pollination algorithm to solve dynamic economic loading of units with piecewise fuel options
Authors: Reddy Y Venkata Krihshna , Reddy M Damodar 
Published: March 2020

This paper presents a Flower Pollination Algorithm (FPA) to solve Dynamic Economic Load Dispatch (DELD) problem with valve-point effects and piecewise fuel options. DELD aims to find out optimum generation schedule of the committed generating units over a certain timing period, sustaining practical constraints and power demands in each interval. Due to the valve-point effect and piecewise fuel options DELD becomes as complex problem, hence in order to achieve the cost reduction and satisfying the dynamic behaviour of the generating units proposed algorithm presented. The practicality of the proposed method is evaluated by performing simulations on standard 10-unit and 19-unit Indian utility systems for a 24 h time schedule at various load patterns. The simulation results attained by the FPA are related with other previous published techniques of the biography. These results clearly show that the proficiency and robustness of the proposed FPA method for resolving the non-linear constrained DELD problem.
Design and fault tolerant analysis of five-phase permanent magnet synchronous motor
Authors: Saari Ahmad Sofian Saari , Ishak Dahaman 
Published: March 2020

<span lang="EN-IN">This paper presents a design of 15-slot/12-pole, five-phase, surface-mounted permanent magnet synchronous motor (PMSM). The five-phase PMSM can be an attractive solution to few applications that demand fault tolerant capability such as in aerospace engineering and electric propulsion. The motor model is first investigated based on the implementation of analytical method. The analytical method derived from the subdomain model of the permanent magnet machine is initially applied to estimate the magnetic flux density distributions for the radial component <em>B</em><sub>r</sub> and the tangential component <em>B</em><sub>t</sub> in the machine air gap. Other important motor characteristics such as phase back-EMF, line back-EMF, cogging torque and electromagnetic torque are also calculated. The analytically calculated results are then compared with the numerical method in a 2D finite element analysis. Additionally, the capability of this PMSM model against faulty conditions are further investigated. The results show that the analytical model of the 15-slot/12-pole, five-phase PMSM provides very accurate motor performance within acceptable error margin. For instance, the average electromagnetic torques, inclusive of the cogging torque, as computed by the analytical and numerical methods are 5.53Nm and 5.33Nm respectively, yielding an error of 3.6%. During faulty conditions, the PMSM can possibly continue to operate with lower output torque, about 60% to 80% of its rated torque, when one-phase or two phase windings are out of service.</span>
Fault disturbances classification analysis using adaptive neuro-fuzzy inferences system
Authors: Shahbudin Shahrani , Kassim Murizah , Mohamad Roslina , Suliman Saiful Izwan , Yusof Yuslinda Wati Mohamad 
Published: March 2020

This paper affords the use of neuro-fuzzy technique called the Adaptive Network–based Fuzzy Inference System (ANFIS) to highlight its ability to perform fault disturbances classiﬁcation tasks using extracted features based on S-transforms methods. The ANFIS model with a ﬁve-layered architecture was trained using extracted features to classify signal data comprising various faults disturbances, namely, voltage sag, swell, impulsive, interruption, notch, and pure signal. Results obtained showed that the ANFIS model is very suitable and can generate excellent classification results provided that the right type and number of Membership Functions (MFs) are used in the classification task.
Solutions of reaction-diffusion equations using similarity reduction and HSSOR iteration
Authors: Mat Ali Nur Afza , Rahman Rostang , Sulaiman Jumat , Ghazali Khadizah 
Published: March 2020

<p>Similarity method is used in finding the solutions of partial differential equation (PDE) in reduction to the corresponding ordinary differential equation (ODE) which are not easily integrable in terms of elementary or tabulated functions. Then, the Half-Sweep Successive Over-Relaxation (HSSOR) iterative method is applied in solving the sparse linear system which is generated from the discretization process of the corresponding second order ODEs with Dirichlet boundary conditions. Basically, this ODEs has been constructed from one-dimensional reaction-diffusion equations by using wave variable transformation. Having a large-scale and sparse linear system, we conduct the performances analysis of three iterative methods such as Full-sweep Gauss-Seidel (FSGS), Full-sweep Successive Over-Relaxation (FSSOR) and HSSOR iterative methods to examine the effectiveness of their computational cost. Therefore, four examples of these problems were tested to observe the performance of the proposed iterative methods. Throughout implementation of numerical experiments, three parameters have been considered which are number of iterations, execution time and maximum absolute error. According to the numerical results, the HSSOR method is the most efficient iterative method in solving the proposed problem with the least number of iterations and execution time followed by FSSOR and FSGS iterative methods.</p>
A Polarimetric Radar Analysis of Ice Microphysical Processes in Melting Layers of Winter Storms Using S-Band Quasi-Vertical Profiles
Authors: Griffin Erica M. , Schuur Terry J. , Ryzhkov Alexander V. 
Published: March 2020

AbstractQuasi-vertical profiles (QVPs) obtained from a database of U.S. WSR-88D data are used to document polarimetric characteristics of the melting layer (ML) in cold-season storms with high vertical resolution and accuracy. A polarimetric technique to define the top and bottom of the ML is first introduced. Using the QVPs, statistical relationships are developed to gain insight into the evolution of microphysical processes above, within, and below the ML, leading to a statistical polarimetric model of the ML that reveals characteristics that reflectivity data alone are not able to provide, particularly in regions of weak reflectivity factor at horizontal polarization ZH. QVP ML statistics are examined for two regimes in the ML data: ZH ≥ 20 dBZ and ZH < 20 dBZ. Regions of ZH ≥ 20 dBZ indicate locations of MLs collocated with enhanced differential reflectivity ZDR and reduced copolar correlation coefficient ρhv, while for ZH < 20 dBZ a well-defined ML is difficult to discern using ZH alone. Evidence of large ZDR up to 4 dB, backscatter differential phase δ up to 8°, and low ρhv down to 0.80 associated with lower ZH (from −10 to 20 dBZ) in the ML is observed when pristine, nonaggregated ice falls through it. Positive correlation is documented between maximum specific differential phase KDP and maximum ZH in the ML; these are the first QVP observations of KDP in MLs documented at S band. Negative correlation occurs between minimum ρhv in the ML and ML depth and between minimum ρhv in the ML and the corresponding enhancement of ZH (ΔZH = ZHmax − ZHrain).
Cats reorganise their feeding behaviours when moving from ad libitum to restricted feeding
Authors: Ligout Séverine , Si Xuemei , Vlaeminck Hanne , Lyn Sandra 
Published: March 2020

Objectives One identified solution to prevent obesity in cats is to control and limit their calorie intake. The objective of the present work was to better elucidate the impact of calorie cut-off on the feeding behaviour of cats. Methods A control (n = 31) and a test group of cats (n = 38) were included in the present study. Both groups received the same food variety during the study. A period of ad libitum feeding was initially set (T0), followed by a 9-month mild calorie restriction period for the test group only (T9; average calorie restriction = 6%), and a final period of ad libitum feeding (T10). The individual cat feeding behaviours were measured via an electronic feeding system, and agonistic interactions between cats during food anticipation via video observations. Generalised linear mixed models were fitted to compare all feeding parameters between periods by group. No statistical analyses could be performed on the agonistic interactions data owing to their structure. Results The feeding behaviour of the control group remained stable during the entire study, while the test group showed fewer but larger meals taken at shorter time intervals and a faster eating rate in response to calorie restriction. The average total number of agonistic interactions per cat increased during the calorie cut-off period in the test group only. One month after returning to ad libitum feeding, all behaviours were largely restored to baseline values. Conclusions and relevance Behavioural changes expressed by cats under calorie restriction can explain some of the difficulties obtaining cat owners’ compliance with dietary restriction, especially in multi-cat households. Feeding strategies should be utilised to help cats be less impulsive and maintain normal feeding patterns when moving away from ad libitum feeding.
Clonal hematopoiesis predicts development of therapy-related myeloid neoplasms post–autologous stem cell transplantation
Authors: Soerensen Johannes Frasez , Aggerholm Anni , Kerndrup Gitte Birk , Hansen Marcus Celik , Ewald Ina Kathrine Lykke , Bill Marie , Ebbesen Lene Hyldahl , Rosenberg Carina Agerbo , Hokland Peter , Ludvigsen Maja , Stidsholt Roug Anne 
Published: March 2020

Abstract
Therapy-related myeloid neoplasms (tMN) develop after exposure to cytotoxic and radiation therapy, and due to their adverse prognosis, it is of paramount interest to identify patients at high risk. The presence of clonal hematopoiesis has been shown to increase the risk of developing tMN. The value of analyzing hematopoietic stem cells harvested at leukapheresis before autologous stem cell transplantation (ASCT) with next-generation sequencing and immunophenotyping represents potentially informative parameters that have yet to be discovered. We performed a nested case-control study to elucidate the association between clonal hematopoiesis, mobilization potential, and aberrant immunophenotype in leukapheresis products with the development of tMN after ASCT. A total of 36 patients with nonmyeloid disease who were diagnosed with tMN after treatment with ASCT were included as case subjects. Case subjects were identified from a cohort of 1130 patients treated with ASCT and matched with 36 control subjects who did not develop tMN after ASCT. Case subjects were significantly poorer mobilizers of CD34+ cells at leukapheresis (P = .016), indicating that these patients possess inferior bone marrow function. Both clonal hematopoiesis (odds ratio, 5.9; 95% confidence interval, 1.8-19.1; P = .003) and aberrant expression of CD7 (odds ratio, 6.6; 95% confidence interval, 1.6-26.2; P = .004) at the time of ASCT were associated with an increased risk of developing tMN after ASCT. In conclusion, clonal hematopoiesis, present at low variant allele frequencies, and aberrant CD7 expression on stem cells in leukapheresis products from patients with nonmyeloid hematologic cancer hold potential for the early identification of patients at high risk of developing tMN after ASCT.
Single-cell mutational profiling enhances the clinical evaluation of AML MRD
Authors: Ediriwickrema Asiri , Aleshin Alexey , Reiter Johannes G. , Corces M. Ryan , Köhnke Thomas , Stafford Melissa , Liedtke Michaela , Medeiros Bruno C. , Majeti Ravindra 
Published: March 2020

AbstractAlthough most patients with acute myeloid leukemia (AML) achieve clinical remission with induction chemotherapy, relapse rates remain high. Next-generation sequencing enables minimal/measurable residual disease (MRD) detection; however, clinical significance is limited due to difficulty differentiating between pre-leukemic clonal hematopoiesis and frankly malignant clones. Here, we investigated AML MRD using targeted single-cell sequencing (SCS) at diagnosis, remission, and relapse (n = 10 relapsed, n = 4 nonrelapsed), with a total of 310 737 single cells sequenced. Sequence variants were identified in 80% and 75% of remission samples for patients with and without relapse, respectively. Pre-leukemic clonal hematopoiesis clones were detected in both cohorts, and clones with multiple cooccurring mutations were observed in 50% and 0% of samples. Similar clonal richness was observed at diagnosis in both cohorts; however, decreasing clonal diversity at remission was significantly associated with longer relapse-free survival. These results show the power of SCS in investigating AML MRD and clonal evolution.
Monoallelic loss-of-function THPO variants cause heritable thrombocytopenia
Authors: Cornish Naomi , Aungraheeta M. Riyaad , FitzGibbon Lucy , Burley Kate , Alibhai Dominic , Collins Janine , Greene Daniel , Downes Kate ,   NIHR BioResource, Westbury Sarah K. , Turro Ernest , Mumford Andrew D. 
Published: March 2020

Key Points
We report rare monoallelic variants of THPO that alter intracellular trafficking and diminish thrombopoietin secretion. Affected cases have autosomal-dominant thrombocytopenia but no other hematological features.
The impact of ultraviolet- and infrared-based laser microdissection technology on phosphoprotein detection in the laser microdissection-reverse phase protein array workflow
Authors: Hunt Allison L. , Pierobon Mariaelena , Baldelli Elisa , Oliver Julie , Mitchell Dave , Gist Glenn , Bateman Nicholas W. , Larry Maxwell G. , Petricoin Emanuel F. , Conrads Thomas P. 
Published: March 2020

AbstractReversible protein phosphorylation represents a key mechanism by which signals are transduced in eukaryotic cells. Dysregulated phosphorylation is also a hallmark of carcinogenesis and represents key drug targets in the precision medicine space. Thus, methods that preserve phosphoprotein integrity in the context of clinical tissue analyses are crucially important in cancer research. Here we investigated the impact of UV laser microdissection (UV LMD) and IR laser capture microdissection (IR LCM) on phosphoprotein abundance of key cancer signaling protein targets assessed by reverse-phase protein microarray (RPPA). Tumor epithelial cells from consecutive thin sections obtained from four high-grade serous ovarian cancers were harvested using either UV LMD or IR LCM methods. Phosphoprotein abundances for ten phosphoproteins that represent important drug targets were assessed by RPPA and revealed no significant differences in phosphoprotein integrity from those obtained using higher-energy UV versus the lower-energy IR laser methods.
Efficacy of relaxin for cisplatin-induced testicular dysfunction and epididymal spermatotoxicity
Authors: Kohsaka Tetsuya , Minagawa Itaru , Morimoto Masashi , Yoshida Takuya , Sasanami Tomohiro , Yoneda Yoshitaka , Ikegaya Naoki , Sasada Hiroshi 
Published: March 2020

AbstractBackgroundCisplatin (CP) is an extremely effective anticancer agent widely used to treat various cancer types, however, the potential side effects include testicular dysfunction. This study was to investigate, using a rat model of CP-induced testicular dysfunction, the protective effects of relaxin (RLN) against oxidative stress, testicular function, histological damage, spermatogenesis, germ-cell apoptosis, and sperm output, and to explore the usefulness of RLN as a potential protective drug for use with CP in chemotherapeutic treatments.MethodsSprague-Dawley male rats were used, which were divided into three groups: sham control, CP, and CP + RLN. Porcine RLN (500 ng/h) or saline was infused for 5 days using an implanted osmotic mini-pump following intraperitoneal injection of CP (6 mg/kg). RLN dose was chosen based on previous studies showing that it resulted in serum relaxin levels comparable to those in rats at the middle of pregnancy. At 5 days after CP administration, samples were collected and assessment of testicular histopathology, germ-cell apoptosis, oxidative stress, lipid peroxidation, and sperm quality was performed as main measures.ResultsThe testicular CP model showed reduced testis weight and significantly decreased spermatogenesis scores. Additionally, CP administration induced a 4.6-fold increase in the apoptotic index associated with a significant increase in oxidative stress and upregulation of pro-apoptoticCasp3and downregulation of anti-apoptoticBcl2levels, resulting in a marked reduction in sperm concentration. However, RLN administration caused a significant reduction in CP-mediated damage by attenuating oxidative stress and cell apoptosis. RLN administration efficiently scavenged ROS via the activation of SOD, CAT, and GPx and upregulation of GSH to prevent lipid peroxidation and decreased apoptosis by alteringBcl2andCasp3expression, thereby reducing histopathological damage and restoring spermatogenesis. Furthermore, RLN ameliorated attenuated sperm motility in the cauda epididymis resulting from CP treatment.ConclusionsThis study clearly indicates that RLN exerts a protective effect against CP-induced testicular damage through attenuation of oxidative stress and suppression of apoptosis. Our findings suggest RLN as a potentially efficacious drug for use with cisplatin chemotherapy in order to ameliorate CP-induced side effects and testicular injury adversely affecting spermatogenesis, sperm quality, and oxidative-stress parameters.