bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute Effects of Water-Based Concurrent Training Intrasession Exercise Sequences on Energy Expenditure in Young Women
Authors: Silva Mariana R. , Alberton Cristine L. , Braga Caroline O. , Pinto Stephanie S. 
Published: December 2019

Background: To compare the acute effects of water-based aerobic–resistance and resistance–aerobic concurrent training (CT) sessions on energy expenditure (EE) during and postexercise in young women.Methods: Nine active women (24 [3] y; 60 [5] kg) completed 4 sessions: (1) familiarization, (2) aquatic maximal test to determine the heart rate corresponding to the anaerobic threshold, (3) CT protocol with aerobic–resistance sequence, and (4) CT protocol with resistance–aerobic sequence. Both protocols started and ended with the participants in the supine position for 30 minutes to perform resting and postexercise oxygen consumption measurements. The water-based resistance protocol comprised 4 sets of 15 seconds at maximal velocity, and the water-based aerobic protocol was performed at a continuous intensity (heart rate corresponding to the anaerobic threshold). EE measurements were calculated based on oxygen consumption and the corresponding caloric equivalent. Pairedttest was used to compare the EE values between the water-based CT intrasession exercise sequences (α = .05).Results: There was no difference between the water-based aerobic–resistance and resistance–aerobic in total EE (330.78 vs 329.56 kcal;P = .96), EE per minute (7.35 vs 7.32 kcal·min−1;P = .96), and postexercise EE (63.65 vs 59.92 kcal;P = .50).Conclusions: The intrasession exercise sequence during water-based CT had no influence on the EE in young women.
Grenvillean evolution of the Beishan Orogen, NW China: Implications for development of an active Rodinian margin
Authors: Soldner Jérémie , Yuan Chao , Schulmann Karel , Štípská Pavla , Jiang Yingde , Zhang Yunying , Wang Xinyu 
Published: December 2019

Abstract
New geochemical and geochronological data are used to characterize the geodynamic setting of metasediments, felsic orthogneisses, and eclogite and amphibolite lenses forming the Beishan complex, NW China, at the southern part of the Central Asian Orogenic Belt. The metasediments correspond compositionally to immature greywackes receiving detritus from a heterogeneous source involving a magmatic arc and a Precambrian continental crust. Metagranitoids, represented by felsic orthogneisses, show both composition of greywacke-derived granitic melt with incompatible trace element patterns similar to the host metasediments. The eclogite lenses are characterized by high Nb contents (5.34–27.3 ppm), high (Nb/La)N (&gt;1), and low Zr/Nb ratios (&lt;4.5), which together with variable and negative whole-rock εNd(t) (–4.3 to –10.3) and zircon εHf(t) (–5.0 to + 2.3) values indicate an origin of enriched mantle source as commonly manifested by back-arc basalts at stretched continental margins. Combined with monazite rare earth element analysis, the in situ monazite U-Pb dating of metagraywacke (880.7 ± 7.9) suggests garnet growth during a high-temperature (HT) metamorphic event. Together with U-Pb dating of zircon metamorphic rims in amphibolite (910.9 ± 3.0 Ma), this indicates that the whole crustal edifice underwent a Grenvillian-age metamorphic event. The protolith ages of the eclogite (889.3 ± 4.8 Ma) and orthogneiss (867.5 ± 1.9 Ma) suggest that basalt underplating and sediment melting were nearly coeval with this HT metamorphism. Altogether, the new data allow placing the Beishan Orogen into a Grenvillean geodynamic scenario where: (1) The late Mesoproterozoic to early Neoproterozoic was marked by deposition of the greywacke sequence coeval with formation of an early arc. (2) Subsequently, an asthenospheric upwelling generated basaltic magma underneath the thinned subcontinental mantle lithosphere that was responsible for HT metamorphism, melting of the back-arc basin greywackes and intrusion of granitic magmas. These events correspond to a Peri-Rodinian supra-subduction system that differs substantially from the Neoproterozoic ophiolite sequences described in the Mongolian part of the Central Asian Orogenic Belt, thus indicating important lateral variability of supra-subduction processes along the Rodinian margin.
Effectiveness and reporting standards of psychological interventions for improving short-term and long-term pain outcomes after total knee replacement: a systematic review
Authors: Whale Katie , Wylde Vikki , Beswick Andrew , Rathbone James , Vedhara Kavita , Gooberman-Hill Rachael 
Published: December 2019

ObjectivesTo assess the effectiveness and reporting standards of psychological interventions for improving outcomes after total knee replacement (TKR).DesignMedline, Embase, and PsycINFO were searched from inception to up to 9 May 2019 with no language restrictions applied. Randomised controlled trials (RCTs) assessing the effectiveness of psychological interventions for short-term and long-term postoperative pain after TKR were included. Screening, data extraction, and assessment of methodological quality were performed in duplicate by two reviewers. The primary effectiveness outcome was postoperative pain severity and the primary harm outcome was serious adverse events. Secondary outcomes included function, quality of life, and psychological well-being. Reporting standards were assessed using the Template for Intervention Description and Replication (TIDieR) checklist for intervention reporting.Results12 RCTs were included, with a total of 1299 participants. Psychological interventions comprised music therapy (five studies), guided imagery and music (one study), hypnosis (one study), progressive muscle relaxation with biofeedback (one study), pain coping skills programme (one study), cognitive–behavioural therapy (two studies), and a postoperative management programme (one study). Due to the high heterogeneity of interventions and poor reporting of harms data, it was not possible to make any definitive statements about the overall effectiveness or safety of psychology interventions for pain outcomes after TKR.ConclusionFurther evidence about the effectiveness of psychological interventions for improving pain outcomes after TKR is needed. The reporting of harm outcomes and intervention fidelity is currently poor and could be improved. Future work exploring the impact of intervention timing on effectiveness and whether different psychological approaches are needed to address acute postoperative pain and chronic postoperative pain would be of benefit.PROSPERO registration numberCRD42018095100.
Peripheral blood helper T cell profiles and their clinical relevance in MOG-IgG-associated and AQP4-IgG-associated disorders and MS
Authors: Liu Jia , Mori Masahiro , Sugimoto Kazuo , Uzawa Akiyuki , Masuda Hiroki , Uchida Tomohiko , Ohtani Ryohei , Kuwabara Satoshi 
Published: December 2019

ObjectiveTo investigate the immunological characteristics and their clinical relevance in anti-myelin oligodendrocyte glycoprotein (MOG)-IgG-associated and anti-aquaporin-4 (AQP4)-IgG-associated disorders (MOGAD and AQPAD) and multiple sclerosis (MS).MethodsWe measured peripheral blood helper T cell subsets (Th1, Th2, Th17 and regulatory T cell (Treg)) in patients with MOGAD (n=26), AQPAD (n=32) and MS (n=28) in the attack and remission phases by flow cytometry with intracellular cytokine staining. We also studied their correlation with clinical parameters. Ten normal subjects served as healthy controls.ResultsIn all the three disorders, Th17 significantly increased at attack, and downregulated in the remission phases, although still elevated compare with healthy controls. MOGAD and AQPAD patients shared the common T cell profiles, while the extent of Th17 shift was more prominent in AQPAD. Patients with MS showed decreased Th2 than ones with MOGAD and AQPAD at attack. In terms of clinical correlation, MS patients showed that higher Th1 and Th17 proportion was associated with more frequent relapse and more severe clinical disability, whereas in MOGAD, higher Treg was associated with milder clinical severity. In AQPAD, no obvious correlation of Th profiles with clinical manifestation was found.ConclusionsThe present study first investigated intracellular cytokine levels among MOGAD, AQPAD and MS. The different patterns and extent of helper T cell profiles could reflect the pathogenesis of each disorders, and may affect disease severity and activity.
Investigation of early signs of systolic and diastolic dysfunction among persons with type 1 diabetes
Authors: Vestberg Daniel , Johansson Magnus Carl , Letho Anette , Pivodic Aldina , Hallström Sara , Ólafsdóttir Arndís Finna , Rosengren Annika , Lind Marcus 
Published: December 2019

BackgroundPersons with type 1 diabetes have a higher risk to develop heart failure than the general population, and the mechanism behind the increased risk is unclear. In epidemiological studies with hospitalisation for heart failure as endpoint HbA1c, body mass index and decreased kidney function are significant risk factors, but it is unclear how these risk factors influence the development of heart failure.MethodsIn this study, we investigated early signs of systolic and diastolic dysfunction with transthoracic echocardiography. Statistical analysis on correlation of risk factors and early signs of diastolic and systolic dysfunction was made.ResultsIn this study population of 287 persons with type 1 diabetes, 160 were men and 127 were women with a mean age of 53.8 (SD 11.6) years and a mean diabetes duration of 36.2 (SD 13.5) years. There were 23 (8.2%) persons who fulfilled the definition of systolic dysfunction (ejection fraction <50% or regional wall motion abnormalities) and 24 persons (9%) the definition for diastolic dysfunction. When comparing the groups with either systolic or diastolic dysfunction to the rest of the population, the only significant risk factor was age in both groups and previous myocardial infarction in the systolic group.ConclusionIn our study population with type 1 diabetes, we found signs of diastolic dysfunction in 9% and systolic dysfunction in 8.2%. Compared with published data from the general population, this rate is somewhat higher in a younger population. Only age was a significant risk factor in the study.
Distributed Computing Column 76
Authors: Alistarh Dan 
Published: December 2019

As this is the first column I am editing, I would like to sincerely thank Jennifer Welch for inviting me as editor, and for being extremely helpful with the transition. I will do my best to maintain the very high standard set for the column by her, and by the previous editors. Following custom, the December issue is devoted to a review of some notable events related to distributed
computing which occurred during the year.
First, congratulations to Alessandro Panconesi and Aravind Srinivasan for being awarded the 2019 Edsger W. Dijkstra Prize in Distributed Computing for their paper “Randomized Distributed
Edge Coloring via an Extension of the Chernoff-Hoeffding Bounds," which appeared in the SIAM Journal on Computing in 1997. The prize is jointly sponsored by ACM and EATCS, and is given alternately at PODC and DISC; this year it was awarded at DISC.
PODC 2019 Review
Authors: Ben-David Naama , Chang Yi-Jun , Dory Michal , Leitersdorf Dean 
Published: December 2019

The 38th ACM SIGACT-SIGOPS Symposium on Principles of Distributed Computing (PODC 2019) was held on July 29-August 2, 2019 at the Double Tree Hilton hotel in Toronto, Canada. With three keynotes, over 40 accepted papers, over 20 accepted brief announcements, two workshops, and roughly 150 attendants, PODC 2019 constituted a composition of fascinating improvements in many areas of distributed and parallel computing.
On the evening of the 31st of July, the conference banquet was held on a cruise over beautiful Lake Ontario and included the best papers award ceremony. The best paper award went to Yi-Jun Chang, and Thatchaphol Saranurak for their work titled, \Improved Distributed Expander Decomposition and Nearly Optimal Triangle Enumeration" [19]; two best student paper awards were given to Yi-Jun Chang, Manuela Fischer, and Yufan Zheng for their work titled, \The Complexity of (Δ + 1) Coloring in Congested Clique, Massively Parallel Computation, and Centralized Local Computation" [17] which was co-authored with Mohsen Gha ari, and Jara Uitto, and to Michal Dory and Dean Leitersdorf for the work on \Fast Approximate Shortest Paths in the Congested Clique" [16] which was co-authored with Keren Censor-Hillel, and Janne H. Korhonen. Congratulations to all the awardees and a special congratulations to Yi-Jun Chang for having received both awards!
This review would be incomplete without mentioning perhaps one of the most notable results in the eld in recent years which was uploaded to the online archive just days before the conference gathered, and which was not presented at PODC 2019 but a ected many works presented at the conference: the work titled, ¶olylogarithmic-Time Deterministic Network Decomposition and Distributed Derandomization" [48] by Vaclav Rozhon, and Mohsen Gha ari. Throughout the entire conference there was talk regarding the implications of this work, culminating with perhaps one of the more memorable moments of PODC 2019, where Mohsen described this result during his talk on a di erent paper which he co-authored with Fabian Kuhn - Mohsen quoted from his and Kuhn's paper [31]: \we provide results that are in some sense the strongest that one can achieve, barring a major breakthrough", and on the next slide was that major breakthrough - a picture of Vaclav Rozhon along with the rst page of [48]. Congratulations to the authors on this work!
We hope that this review will give readers the opportunity to experience some of PODC 2019 and potentially attend the conference in future years. Thank you to the organizers and authors for a captivating and though-provoking conference!
SETH vs Approximation
Authors: Rubinstein Aviad , Williams Virginia Vassilevska 
Published: December 2019

Our story is about hardness of problems in P, but its roots begin with two algorithmic approaches that have been developed to cope with NP-hard problems: approximation algorithms and fasterthan- brute-force algorithms.
Approximation algorithms were proposed as a response for NP-hardness almost immediately (in historical perspective of almost half a century), and have been one of the most celebrated success stories of our eld. An outstanding complexity result in this area, which has since turned into a sub- eld of its own, is the Probabilistically Checkable Proof (PCP) Theorem. For many problems like Max-3-SAT we now have nearly tight hardness-of-approximation results.
Acetazolamide does not alter endurance exercise performance at 3,500-m altitude
Authors: Bradbury Karleigh E. , Yurkevicius Beau R. , Mitchell Katherine M. , Coffman Kirsten E. , Salgado Roy M. , Fulco Charles S. , Kenefick Robert W. , Charkoudian Nisha 
Published: December 2019

Acetazolamide (AZ) is a medication commonly used to prevent acute mountain sickness (AMS) during rapid ascent to high altitude. However, it is unclear whether AZ use impairs exercise performance; previous literature regarding this topic is equivocal. The purpose of this study was to evaluate the impact of AZ on time-trial (TT) performance during a 30-h exposure to hypobaric hypoxia equivalent to 3,500-m altitude. Ten men [sea-level peak oxygen consumption (VO2peak): 50.8 ± 6.5 mL·kg−1·min−1; body fat %: 20.6 ± 5.2%] completed 2 30-h exposures at 3,500 m. In a crossover study design, subjects were given 500 mg/day of either AZ or a placebo. Exercise testing was completed 2 h and 24 h after ascent and consisted of 15-min steady-state treadmill walking at 40%–45% sea-level VO2peak, followed by a 2-mile self-paced treadmill TT. AMS was assessed after ~12 h and 22 h at 3,500 m. The incidence of AMS decreased from 40% with placebo to 0% with AZ. Oxygen saturation was higher ( P < 0.05) in AZ versus placebo trials at the end of the TT after 2 h (85 ± 3% vs. 79 ± 3%) and 24 h (86 ± 3% vs. 81 ± 4%). There was no difference in time to complete 2 miles between AZ and PL after 2 h (20.7 ± 3.2 vs. 22.7 ± 5.0 min, P > 0.05) or 24 h (21.5 ± 3.4 vs. 21.1 ± 2.9 min, P > 0.05) of exposure to altitude. Our results suggest that AZ (500 mg/day) does not negatively impact endurance exercise performance at 3,500 m.NEW & NOTEWORTHY To our knowledge, this is the first study to examine the impact of acetazolamide (500 mg/day) versus placebo on self-paced, peak-effort exercise performance using a short-duration exercise test in a hypobaric hypoxic environment with a repeated-measures design. In the present study, acetazolamide did not impact exercise performance after 2-h or 24-h exposure to 3,500-m simulated altitude.
ФОРМУВАННЯ ПРОФЕСІЙНО ЗОРІЄНТОВАНИХ КОМУНІКАТИВНИХ НАВИЧОК СТУДЕНТІВ-ІНОЗЕМЦІВ МЕДИЧНИХ СПЕЦІАЛЬНОСТЕЙ У ПРОЦЕСІ ВИВЧЕННЯ УКРАЇНСЬКОЇ МОВИ ЯК ІНОЗЕМНОЇ
Authors: Melnyk T. P. 
Published: December 2019

У статті проаналізовано одне з основних завдань програми підготовки іноземного фахівця медичної сфери, яке полягає в підвищенні рівня культури усного мовлення, виробленні вміння правильно, логічно та грамотно висловлювати думку. Запропоновано методику формування професійно зорієнтованих діалогічних навичок студентів-іноземців медичних спеціальностей у процесі вивчення української мови як іноземної. Добір завдань спрямовано на реалізацію комунікативних потреб студентів-іноземців у різних сферах спілкування: науковій (для отримання конкурентоспроможної підготовки за обра­ним фахом), суспільно-політичній і соціально-культурній (для належної адаптації та повноцінного орієнтування в новому соціально-культурному середовищі, особистісного культурного зростання), побутовій (для задоволення потреб повсякденного життя), а також для виховання гармонійної особистості, що здатна до міжкультурного діалогу.
Запропоновано систему вправ, які сприятимуть опануванню вмінь та навичок спілкуватися в усній і письмовій формах відповідно до цілей і соціальних норм мовленнєвої поведінки в типових сферах і ситуаціях. З’ясовано, що виконання окресленого комплексу завдань сприятиме виробленню в іноземних студентів навичок: 1) звертатися до інших із запитаннями та відповідати на запитання; 2) підтримувати та продовжувати розмову відповідно до ситуації спілкування; 3) будувати діалог на запропоновану тему; 4) вдало використовувати форми мовленнєвого етикету; 5) відповідати на запитання за змістом тексту та переказувати зміст текстів. Матеріали, описані в статті, призначені для студентів-іноземців, які володіють мовою на початковому рівні та здатні застосовувати здобуті знання з української мови для досягнення соціальної та професійної взаємодії в українськомовному середовищі.
ЗАСТОСУВАННЯ COMSOL MULTIPHYSICS ДЛЯ МАТЕМАТИЧНОГО МОДЕЛЮВАННЯ ВИВЧЕННЯ ПРОЦЕСУ РОЗПАДУ ДНК У ПЛАЗМІ
Authors: Vakulenko D. V. , Kuchvara O. M. , Semenets A. V. , Andrushchak I. Ye. 
Published: December 2019

Використання сучасних комп’ютерних технологій у процесі викладання курсу комп’ютерного моделювання у фармації сприяє формуванню вмінь та навичок в умовах невпинного розвитку комп’ютеризації та впровадженню математичного моделювання у фармації. Зокрема, у статті розглянуто переваги та недоліки застосування математичного моделювання за допомогою COMSOL Multiphysics у формуванні компетентності майбутніх фармацевтів.
Розглянуто ступінь ефективності, зручності та доступності застосування програмного середовища COMSOL Multiphysics в курсі комп’ютерного моделювання у фармації для студентів 3-го курсу фармацевтичного факультету на прикладі вивчення процесу розпаду ДНК у плазмі.
Використання сучасних комп’ютерних продуктів у процесі викладання комп’ютерних технологій у фармації сприяє формуванню вмінь та навичок із математичного моделювання у фармації, зокрема, генна терапія – один із прикладів біотехнології клінічного застосування. Вирішення головної проблеми – доставки генів, пов’язаних із транспортуванням плазмідної ДНК (пДНК) до мішеней, та перетворення між різними формами пДНК, використання функції оцінки параметрів за допомогою інженерії та реакцій інтерфейсу, для пошуку констант швидкості трьох послідовних реакцій, що беруть участь у ДНК процесі деградації.
Building Long Homogeneous Temperature Series across Europe: A New Approach for the Blending of Neighboring Series
Authors: Squintu Antonello A. , van der Schrier Gerard , van den Besselaar Else J. M. , Cornes Richard C. , Klein Tank Albert M. G. 
Published: December 2019

ABSTRACTLong and homogeneous series are a necessary requirement for reliable climate analysis. Relocation of measuring equipment from one station to another, such as from the city center to a rural area or a nearby airport, is one of the causes of discontinuities in these long series that may affect trend estimates. In this paper, an updated procedure for the composition of long series, by combining data from nearby stations, is introduced. It couples an evolution of the blending procedure already implemented within the European Climate Assessment and Dataset (ECA&D, which combines data from stations no more than 12.5 km apart from each other) with a duplicate removal, alongside the quantile matching homogenization procedure. The ECA&D contains approximately 3000 homogenized series for each temperature variable prior to the blending procedure, and approximately 820 of these are longer than 60 years; the process of blending increases the number of long series to more than 900. Three case studies illustrate the effects of the homogenization on single blended series, showing the effectiveness of separate adjustments on extreme and mean values (Geneva, Switzerland), on cases in which blending is complex (Rheinstetten, Germany), and on series that are completed by adding relevant portions of Global Telecommunications System synoptic data (Siauliai, Lithuania). A trend assessment on the whole European continent reveals the removal of negative and very large trends, demonstrating a stronger spatial consistency. The new blended and homogenized dataset will allow a more reliable use of temperature series for indices calculation and for the calculation of gridded datasets and it will be available online for users (https://www.ecad.eu).
Finite Sample Inference for Multiply Imputed Synthetic Data under a Multiple Linear Regression Model
Authors: Klein Martin D. , Zylstra John , Sinha Bimal K. 
Published: December 2019

In this article, we develop finite sample inference based on multiply imputed synthetic data generated under the multiple linear regression model. We consider two methods of generating the synthetic data, namely posterior predictive sampling and plug-in sampling. Simulation results are presented to confirm that the proposed methodology performs as the theory predicts and to numerically compare the proposed methodology with the current state-of-the-art procedures for analysing multiply imputed partially synthetic data. AMS 2000 subject classification: 62F10, 62F25, 62J05
On Fixed width Confidence Interval Estimation of the Common Mean in Symmetric Multivariate Normal Distribution
Authors: Bandyopadhyay Uttam , Sarkar Pritam 
Published: December 2019

This article deals with purely and accelerated sequential sampling procedures to find fixed-width confidence interval of completely symmetric multivariate normal mean. Procedures are studied asymptotically and are evaluated numerically. AMS 2000 subject classification: 62F25 62H12