bluuebunny/crossref_metadata_2025_split huggingface dataset:
In situ monitoring of photocatalyzed isomerization reactions on a microchip flow reactor by IR-MALDI ion mobility spectrometry
Authors: Prüfert Chris , Urban Raphael David , Fischer Tillmann Georg , Villatoro José , Riebe Daniel , Beitz Toralf , Belder Detlev , Zeitler Kirsten , Löhmannsröben Hans-Gerd 
Published: September 2020

AbstractThe visible-light photocatalytic E/Z isomerization of olefins can be mediated by a wide spectrum of triplet sensitizers (photocatalysts). However, the search for the most efficient photocatalysts through screenings in photo batch reactors is material and time consuming. Capillary and microchip flow reactors can accelerate this screening process. Combined with a fast analytical technique for isomer differentiation, these reactors can enable high-throughput analyses. Ion mobility (IM) spectrometry is a cost-effective technique that allows simple isomer separation and detection on the millisecond timescale. This work introduces a hyphenation method consisting of a microchip reactor and an infrared matrix-assisted laser desorption ionization (IR-MALDI) ion mobility spectrometer that has the potential for high-throughput analysis. The photocatalyzed E/Z isomerization of ethyl-3-(pyridine-3-yl)but-2-enoate (E-1) as a model substrate was chosen to demonstrate the capability of this device. Classic organic triplet sensitizers as well as Ru-, Ir-, and Cu-based complexes were tested as catalysts. The ionization efficiency of the Z-isomer is much higher at atmospheric pressure which is due to a higher proton affinity. In order to suppress proton transfer reactions by limiting the number of collisions, an IM spectrometer working at reduced pressure (max. 100 mbar) was employed. This design reduced charge transfer reactions and allowed the quantitative determination of the reaction yield in real time. Among 14 catalysts tested, four catalysts could be determined as efficient sensitizers for the E/Z isomerization of ethyl cinnamate derivative E-1. Conversion rates of up to 80% were achieved in irradiation time sequences of 10 up to 180 s. With respect to current studies found in the literature, this reduces the acquisition times from several hours to only a few minutes per scan.
Gadoxetic acid-enhanced MRI in primary sclerosing cholangitis: added value in assessing liver function and monitoring disease progression
Authors: Elkilany Aboelyazid , Geisel Dominik , Müller Tobias , Fischer Andreas , Denecke Timm 
Published: September 2020

Abstract
Purpose
To investigate the added value of gadoxetic acid-enhanced MRI in monitoring liver function and disease progression in patients with primary sclerosing cholangitis (PSC).

Methods
We retrospectively identified 104 consecutive patients (75 males; mean age 41.98 ± 12.5 years) with confirmed diagnosis of PSC who underwent 227 gadoxetic acid-enhanced MRI examinations between January 2008 and May 2019. Relative enhancement (RE) of the liver was correlated with the results of liver function tests (LFTs), scoring models (Model for End-Stage Liver Disease (MELD) score, Mayo Risk Score (MRS), Amsterdam-Oxford model (AOM)), and qualitative MRI findings. In addition, results were analyzed separately for excretory MRI examinations (n = 164) and nonexcretory examinations (n = 63) depending on excretion of gadoxetic acid into the common bile duct in the hepatobiliary phase (HBP).

Results
There was a significant correlation of RE with MRS (r = − 0.652), MELD score (r = − 0.474), AOM (r = − 0.468), and LFTs (P < 0.001). RE and albumin were significantly higher in the excretory group whereas scoring models, bilirubin, aspartate aminotransferase, alkaline phosphatase, and international normalized ratio were lower (P < 0.001). RE was lower in segments with absent HBP gadoxetic acid excretion into dilated bile ducts, reduced HBP parenchymal enhancement, atrophy, T2 hyperintensity, and bile duct abnormalities (P < 0.001).

Conclusion
Relative enhancement of the liver in gadoxetic acid-enhanced MRI can be used to evaluate global and regional liver function and monitor disease progression in patients with PSC. Hepatobiliary phase gadoxetic acid biliary excretion appears to be a reproducible qualitative parameter for evaluating disease severity that can be easily integrated into routine clinical practice.
Colorectal cancer in Crohn’s colitis is associated with advanced tumor invasion and a poorer survival compared with ulcerative colitis: a retrospective dual-center study
Authors: Vetter Leonie E. , Merkel Susanne , Bénard Alan , Krautz Christian , Brunner Maximilian , Mittelstädt Anke , Schlegel Nicolas , Wiegering Armin , Germer Christoph-Thomas , Weber Klaus , Grützmann Robert , Weber Georg F. 
Published: September 2020

Abstract
Purpose
Colorectal cancer is a well-recognized complication of inflammatory bowel diseases (IBD), such as ulcerative colitis (UC) and Crohn’s colitis (CC). In this study, we assess the clinico-pathological features and outcomes of patients with colorectal cancer from UC in comparison with CC.

Methods
Data of all patients with colitis-associated cancer (CAC) who underwent surgery at Erlangen or Würzburg University Clinic between 1995 and 2015 were selected. Clinical, histopathological, and survival data were analyzed retrospectively.

Results
Of all 88 patients with CAC, 20 patients had Crohn’s colitis and 68 patients had ulcerative colitis. We observed a young median age at tumor diagnosis (49.5 years UC; 45.5 years CC, p = 0.208) in both diseases and a long median disease duration before CAC (19 years UC; 18 years CC; p = 0.840). Patients with CC suffered more often from rectal cancer (14 (70.0%) in CC; 23 (33.8%) in UC; p = 0.005) and advanced tumor stages (8 (47.0%) pT4 in CC; 14 (25.0%) pT4/ypT4 in UC; p = 0.008). Five-year overall survival rate was 39.3% for CC and 67.1% for UC (p = 0.009 for difference between the groups). Survival did not differ significantly between UC and CC in the multivariate analysis after correction for UICC tumor stage.

Conclusion
CAC in CC showed advanced tumor stages associated with reduced survival compared with CAC in UC. This may be explained by less intense surveillance in patients with CC leading to delayed cancer diagnosis.
Intra-individual physiological response of recreational runners to different training mesocycles: a randomized cross-over study
Authors: Düking Peter , Holmberg Hans-Christer , Kunz Philipp , Leppich Robert , Sperlich Billy 
Published: September 2020

AbstractPurposePronounced differences in individual physiological adaptation may occur following various training mesocycles in runners. Here we aimed to assess the individual changes in performance and physiological adaptation of recreational runners performing mesocycles with different intensity, duration and frequency.MethodsEmploying a randomized cross-over design, the intra-individual physiological responses [i.e., peak ($${\dot{\text V}}{\text O}_{2 {\rm peak}}$$V˙O2peak) and submaximal ($${\dot{\text V}}{\text O}_{2 {\rm submax}}$$V˙O2submax) oxygen uptake, velocity at lactate thresholds(V2, V4)] and performance (time-to-exhaustion (TTE)) of 13 recreational runners who performed three 3-week sessions of high-intensity interval training (HIIT), high-volume low-intensity training (HVLIT) or more but shorter sessions of HVLIT (high-frequency training; HFT) were assessed.Results$${\dot{\text V}}{\text O}_{2 {\rm submax}}$$V˙O2submax, V2,V4and TTE were not altered by HIIT, HVLIT or HFT (p > 0.05).$${\dot{\text V}}{\text O}_{2 {\rm peak}}$$V˙O2peakimproved to the same extent following HVLIT (p = 0.045) and HFT (p = 0.02). The number of moderately negative responders was higher following HIIT (15.4%); and HFT (15.4%) than HVLIT (7.6%). The number of very positive responders was higher following HVLIT (38.5%) than HFT (23%) or HIIT (7.7%). 46% of the runners responded positively to two mesocycles, while 23% did not respond to any.ConclusionOn a group level, none of the interventions altered$${\dot{\text V}}{\text O}_{2 {\rm submax}}$$V˙O2submax, V2, V4or TTE, while HVLIT and HFT improved$${\dot{\text V}}{\text O}_{2 {\rm peak}}$$V˙O2peak. The mean adaptation index indicated similar numbers of positive, negative and non-responders to HIIT, HVLIT and HFT, but more very positive responders to HVLIT than HFT or HIIT. 46% responded positively to two mesocycles, while 23% did not respond to any. These findings indicate that the magnitude of responses to HIIT, HVLIT and HFT is highly individual and no pattern was apparent.
The provision of nutritional advice and care for cancer patients: a UK national survey of healthcare professionals
Authors: Murphy Jane L. , Munir Fehmidah , Davey Fiona , Miller Laura , Cutress Ramsey , White Rhys , Lloyd Megan , Roe Justin , Granger Carol , Burden Sorrel , Turner Lesley 
Published: September 2020

Abstract
Purpose
People living with and beyond cancer often experience nutrition-related issues and should receive appropriate advice on nutrition that is consistent and evidence based. The aim of this study was to investigate current practice for the provision of nutritional care by healthcare professionals (HCPs) from a UK national survey produced by the National Institute for Health Research (NIHR) Cancer and Nutrition Collaboration.

Methods
An online survey sent to professional groups and networks included questions on discussing nutrition, providing information, awareness of guidelines, confidence in providing nutritional advice, training and strategies for improving nutritional management.

Results
There were 610 HCPs who responded including nurses (31%), dietitians (25%), doctors (31%) and speech and language therapists (9%). The majority of HCPs discusses nutrition (94%) and provides information on nutrition (77%). However, only 39% of HCPs reported being aware of nutritional guidelines, and just 20% were completely confident in providing nutritional advice. Awareness of guidelines varied between the different professional groups with most but not all dietitians reporting the greatest awareness of guidelines and GPs the least (p = 0.001). Those HCPs with a greater awareness of guidelines had received training (p = 0.001) and were more likely to report complete confidence in providing nutritional advice (p = 0.001).

Conclusion
Whilst HCPs discuss nutrition with cancer patients and may provide information, many lack an awareness of guidelines and confidence in providing nutritional advice. To ensure consistency of practice and improvements in patient care, there is scope for enhancing the provision of appropriate nutrition education and training.
The silent transition from curative to palliative treatment: a qualitative study about cancer patients’ perceptions of end-of-life discussions with oncologists
Authors: Kitta A. , Hagin A. , Unseld M. , Adamidis F. , Diendorfer T. , Masel E. K. , Kirchheiner K. 
Published: September 2020

Abstract
Objective
The aims of the study were to examine patients’ experiences of end-of-life (EOL) discussions and to shed light on patients’ perceptions of the transition from curative to palliative care.

Methods
This study was based on a qualitative methodology; we conducted semi-structured interviews with advanced cancer patients admitted to the palliative care unit (PCU) of the Medical University of Vienna. Interviews were recorded digitally and transcribed verbatim. Data were analyzed based on thematic analysis, using the MAXQDA software.

Results
Twelve interviews were conducted with patients living with terminal cancer who were no longer under curative treatment. The findings revealed three themes: (1) that the medical EOL conversation contributed to the transition process from curative to palliative care, (2) that patients’ information preferences were ambivalent and modulated by defense mechanisms, and (3) that the realization and integration of medical EOL conversations into the individual’s personal frame of reference is a process that needs effort and information from different sources coming together.

Conclusions
The results of the present study offer insight into how patients experienced their transition from curative to palliative care and into how EOL discussions are only one element within the disease trajectory. Many patients struggle with their situations. Therefore, more emphasis should be put on repeated offers to have EOL conversations and on early integration of aspects of palliative care into the overall treatment.
Can Heating Induce Borehole Closure?
Authors: Xie Xiyang , Bauer Andreas , Stenebråten Jørn F. , Bakheim Sigurd , Lavrov Alexandre , Fjær Erling , Kristiansen Tron G. 
Published: September 2020

AbstractThe current study shows that heating a cased borehole in low-permeability shale rock can induce plastic deformation, leading to the closure of the casing annulus and decreasing annulus connectivity. The thermally induced borehole closure is interesting for the field operation of plug and abandonment (P&A), as it potentially saves operation cost and time by avoiding cutting casing and cementing. Lab experiments and numerical simulations are implemented to investigate the thermally induced borehole closure. Pierre shale and a field shale are tested. The lab experiments are performed by heating the borehole wall in a 10-cm-OD hollow cylinder specimen. Here, a novel experimental setup is applied, allowing for measuring temperature and pore pressure at different radii inside the specimen. Both the experimental data and the post-test CT images of the rock samples indicate the rock failure by borehole heating, and under certain conditions, heating results in an annulus closure. The decrease of hydraulic conductivity through the casing annulus is observed, but this decrease is not enough to form the hydraulic-sealed annulus barrier, based on the results obtained so far. Lab-scale finite-element simulations aim to match the lab results to obtain poro-elastoplastic parameters. Then the field-scale simulations assess the formation of shale barriers by heating in field scenarios. Overall, (i) the lab experiments show that heating a borehole can increase the pore pressure in shale and hence induce rock failure; (ii) the numerical simulations match the experimental results reasonably well and indicate that the heating-induced borehole closure can sufficiently seal the casing annulus in the field-scale simulation.
A Spherical Indentation Study on the Mechanical Response of Selected Rocks in the Range from Very Hard to Soft with Particular Interest to Drilling Application
Authors: Saadati M. , Weddfelt K. , Larsson P.-L. 
Published: September 2020

AbstractThe focus of this work is toward an investigation of the mechanical response of a variety of rocks to indentation loading as a close condition to drilling application. A rock classification method is introduced based on the mechanical response of the rock when loaded by a spherical indenter. Spherical shape is selected for the indenter as a common geometry, which to some extent represents most of the new or worn inserts in drill bits. Both of the force–penetration and fragmentation responses are studied and the results are categorized accordingly. Indentation loading of a quasi-brittle medium like rock contains a complex three-dimensional stress state, in which the compressive strength, tensile strength, compaction behavior and the brittleness of the rock all together are reflected in its mechanical response. Therefore, depending on the type of the rock and its properties, this response is also very diverse for different rocks. Eight types of rocks are investigated and the results from the force–penetration and fragmentation responses are summarized into three different classes.
Get secure soon: attachment in abused adolescents and young adults before and after trauma-focused cognitive processing therapy
Authors: Rimane Eline , Steil Regina , Renneberg Babette , Rosner Rita 
Published: September 2020

AbstractSevere posttraumatic stress symptoms (PTSS) are connected to a variety of health-related and interpersonal problems, among them are the insecure attachment orientations. However, psychotherapy seems to improve not only PTSS but also attachment insecurities. In a large multicenter, randomized clinical trial, the attachment characteristics and PTSS of 85 adolescents and young adults (aged 14–21 years) with clinically relevant abuse-related PTSS were assessed at study entry, at the end of treatment, and 3 months after the end of treatment. Participants were randomized either to a developmentally adapted cognitive processing therapy (D-CPT) or to a wait-list with treatment advice (WL/TA). The purpose of the study was to analyze the association between PTSS and attachment at study entry as well as changes in attachment during the trial. We found that attachment-related avoidance (AR avoidance) was positively associated with PTSS from both self-reports and clinician ratings, whereas attachment-related anxiety (AR anxiety) was only related to self-reported PTSS (Pearson correlation coefficients between 0.37 and 0.46). Changes in AR anxiety occurred in both conditions at some point during the study (baseline to 3-month follow-up effect size wasd = 0.60 for D-CPT andd = 0.44 for WL/TA) whereas for AR avoidance, only participants in D-CPT improved significantly (baseline to 3-month follow-up effect size wasd = 0.75). The results indicate that PTSS and attachment are connected. Positive changes in attachment insecurities brought about by trauma-focused psychotherapy seem possible.Trial registration: German Clinical Trials Register (DRKS); Germanctr.de; identifier: DRKS00004787; date of registration: 18 March 2013.
A new three-step hybrid approach is a safe procedure for incisional hernia: early experiences with a single centre retrospective cohort
Authors: van den Dop L. Matthijs , de Smet Gijs H. J. , Bus Michaël P. A. , Lange Johan F. , Koch Sascha M. P. , Hueting Willem E. 
Published: September 2020

Abstract
Purpose
In this study, a three-step novel surgical technique was developed for incisional hernia, in which a laparoscopic procedure with a mini-laparotomy is combined: so-called ‘three-step incisional hybrid repair’. The aim of this study was to reduce the risk of intestinal lacerations during adhesiolysis and recurrence rate by better symmetrical overlap placement of the mesh.

Objectives
To evaluate first perioperative outcomes with this technique.

Methods
From 2016 to 2020, 70 patients (65.7% females) with an incisional hernia of > 2 and ≤ 10 cm underwent a elective three-step incisional hybrid repair in two non-academic hospitals performed by two surgeons specialised in abdominal wall surgery. Intra- and postoperative complications, operation time, hospitalisation time and hernia recurrence were assessed.

Results
Mean operation time was 100 min. Mean hernia size was 4.8 cm; 45 patients (64.3%) had a hernia of 1–5 cm, 25 patients (35.7%) of 6–10 cm. Eight patients had a grade 1 complication (11.4%), five patients a grade 2 (7.1%), two patients (2.8%) a grade 4 complication and one patient (1.4%) a grade 5 complication. Five patients had an intraoperative complication (7.0%), two enterotomies, one serosa injury, one omentum bleeding and one laceration of an epigastric vessel. Mean length of stay was 3.3 days. Four patients (5.6%) developed a hernia recurrence during a mean follow-up of 19.5 weeks.

Conclusion
A three-step hybrid incisional hernia repair is a safe alternative for incisional hernia repair. Intraoperative complications rate was low.
Epigenetic regulation of the lineage specificity of primary human dermal lymphatic and blood vascular endothelial cells
Authors: Tacconi Carlotta , He Yuliang , Ducoli Luca , Detmar Michael 
Published: September 2020

AbstractLymphatic and blood vascular endothelial cells (ECs) share several molecular and developmental features. However, these two cell types possess distinct phenotypic signatures, reflecting their different biological functions. Despite significant advances in elucidating how the specification of lymphatic and blood vascular ECs is regulated at the transcriptional level during development, the key molecular mechanisms governing their lineage identity under physiological or pathological conditions remain poorly understood. To explore the epigenomic signatures in the maintenance of EC lineage specificity, we compared the transcriptomic landscapes, histone composition (H3K4me3 and H3K27me3) and DNA methylomes of cultured matched human primary dermal lymphatic and blood vascular ECs. Our findings reveal that blood vascular lineage genes manifest a more ‘repressed’ histone composition in lymphatic ECs, whereas DNA methylation at promoters is less linked to the differential transcriptomes of lymphatic versus blood vascular ECs. Meta-analyses identified two transcriptional regulators, BCL6 and MEF2C, which potentially govern endothelial lineage specificity. Notably, the blood vascular endothelial lineage markers CD34, ESAM and FLT1 and the lymphatic endothelial lineage markers PROX1, PDPN and FLT4 exhibited highly differential epigenetic profiles and responded in distinct manners to epigenetic drug treatments. The perturbation of histone and DNA methylation selectively promoted the expression of blood vascular endothelial markers in lymphatic endothelial cells, but not vice versa. Overall, our study reveals that the fine regulation of lymphatic and blood vascular endothelial transcriptomes is maintained via several epigenetic mechanisms, which are crucial to the maintenance of endothelial cell identity.
Shear-horizontal waves in periodic layered nanostructure with both nonlocal and interface effects
Authors: Tian Ru , Liu Jinxi , Pan E. N. , Wang Yuesheng 
Published: September 2020

AbstractThe propagation of shear-horizontal (SH) waves in the periodic layered nanocomposite is investigated by using both the nonlocal integral model and the nonlocal differential model with the interface effect. Based on the transfer matrix method and the Bloch theory, the band structures for SH waves with both vertical and oblique incidences to the structure are obtained. It is found that by choosing appropriate interface parameters, the dispersion curves predicted by the nonlocal differential model with the interface effect can be tuned to be the same as those based on the nonlocal integral model. Thus, by propagating the SH waves vertically and obliquely to the periodic layered nanostructure, we could invert, respectively, the interface mass density and the interface shear modulus, by matching the dispersion curves. Examples are further shown on how to determine the interface mass density and the interface shear modulus in theory.
COVID-19 detection and disease progression visualization: Deep learning on chest X-rays for classification and coarse localization
Authors: Zebin Tahmina , Rezvy Shahadate 
Published: September 2020

AbstractChest X-rays are playing an important role in the testing and diagnosis of COVID-19 disease in the recent pandemic. However, due to the limited amount of labelled medical images, automated classification of these images for positive and negative cases remains the biggest challenge in their reliable use in diagnosis and disease progression. We implemented a transfer learning pipeline for classifying COVID-19 chest X-ray images from two publicly available chest X-ray datasets1,2. The classifier effectively distinguishes inflammation in lungs due to COVID-19 and Pneumonia from the ones with no infection (normal). We have used multiple pre-trained convolutional backbones as the feature extractor and achieved an overall detection accuracy of 90%, 94.3%, and 96.8% for the VGG16, ResNet50, and EfficientNetB0 backbones respectively. Additionally, we trained a generative adversarial framework (a CycleGAN) to generate and augment the minority COVID-19 class in our approach. For visual explanations and interpretation purposes, we implemented a gradient class activation mapping technique to highlight the regions of the input image that are important for predictions. Additionally, these visualizations can be used to monitor the affected lung regions during disease progression and severity stages.