bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physician-related factors associated with unscheduled revisits to the emergency department and admission to the intensive care unit within 72 h
Authors: Chang Chao-Sheng , Lee Kuo-Hsin , Su Hung-Yuan , Sun Cheuk-Kwan , Tsai I-Ting , Lo Ying-Ying , Hsu Chih-Wei 
Published: August 2020

AbstractInvestigation of physician-related causes of unscheduled revisits to the emergency department (ED) within 72 h with subsequent admission to the intensive care unit (ICU) is an important parameter of emergency care quality. Between 2012 and 2017, medical records of all adult patients who visited the ED and returned within 72 h with subsequent ICU admission were retrospectively reviewed by three experienced emergency physicians. Study parameters were categorized into “input” (Patient characteristics), “throughput” (Time spent on first ED visit and seniority of emergency physicians, and “output” (Charlson Comorbidity Index). Of the 147 patients reviewed for the causes of ICU admission, 35 were physician-related (23.8%). Eight belonged to more urgent categories, whereas the majority (n = 27) were less urgent. Patients who spent less time on their first ED visits before discharge (< 2 h) were significantly associated with physician-related causes of ICU admission, whereas there was no significant difference in other “input,” “throughput,” and “output” parameters between the “physician-related” and “non-physician-related” groups. Short initial management time was associated with physician-related causes of ICU admission in patients with initial less urgent presentations, highlighting failure of the conventional triage system to identify potentially life-threatening conditions and possibility of misjudgement because of the patients' apparently minor initial presentations.
Mutational signature SBS8 predominantly arises due to late replication errors in cancer
Authors: Singh Vinod Kumar , Rastogi Arnav , Hu Xiaoju , Wang Yaqun , De Subhajyoti 
Published: August 2020

AbstractAlthough a majority of somatic mutations in cancer are passengers, their mutational signatures provide mechanistic insights into mutagenesis and DNA repair processes. Mutational signature SBS8 is common in most cancers, but its etiology is debated. Incorporating genomic, epigenomic, and cellular process features for multiple cell-types we develop genome-wide composite epigenomic context-maps relevant for mutagenesis and DNA repair. Analyzing somatic mutation data from multiple cancer types in their epigenomic contexts, we show that SBS8 preferentially occurs in gene-poor, lamina-proximal, late replicating heterochromatin domains. While SBS8 is uncommon among mutations in non-malignant tissues, in tumor genomes its proportions increase with replication timing and speed, and checkpoint defects further promote this signature - suggesting that SBS8 probably arises due to uncorrected late replication errors during cancer progression. Our observations offer a potential reconciliation among different perspectives in the debate about the etiology of SBS8 and its relationship with other mutational signatures.
Room-temperature quantum spin Hall phase in laser-patterned few-layer 1T′- MoS2
Authors: Katsuragawa Naoki , Nishizawa Mizuki , Nakamura Taketomo , Inoue Taiki , Pakdel Sahar , Maruyama Shigeo , Katsumoto Shingo , Palacios Juan Jose , Haruyama Junji 
Published: August 2020

AbstractThe quantum-spin-Hall (QSH) phase of 2D topological insulators has attracted increased attention since the onset of 2D materials research. While large bulk gaps with vanishing edge gaps in atomically thin layers have been reported, verifications of the QSH phase by resistance measurements are comparatively few. This is partly due to the poor uniformity of the bulk gap induced by the substrate over a large sample area and/or defects induced by oxidation. Here, we report the observation of the QSH phase at room-temperature in the 1T′-phase of few-layer MoS2 patterned onto the 2H semiconducting phase using low-power and short-time laser beam irradiation. Two different resistance measurements reveal hallmark transport conductance values, ~e2/2 h and e2/4 h, as predicted by the theory. Magnetic-field dependence, scanning tunneling spectra, and calculations support the emergence of the room-temperature QSH phase. Although further experimental verification is still desirable, our results provide feasible application to room-temperature topological devices.
Identification of a subpopulation of long-term tumor-initiating cells in colon cancer
Authors: Peng Linglong , Xiong Yongfu , Wang Rong , Xiang Ling , Zhou He , Gu Haitao 
Published: July 2020

Abstract
Long-term tumor-initiating cells (LT-TICs) are viewed as a quantifiable target for colon cancer therapy owing to their extensive self-renewal and tumorigenic and metastatic capacities. However, it is unknown which subpopulation of colon cancer cells contains LT-TICs. Here, based on the methods for isolating and identifying cancer stem cells (CSCs) and the functional features of LT-TICs, we aimed to identify a subpopulation of LT-TICs. Among the six cell lines assessed, our results showed that CD133 and CD44 coexpression was only detected in HCT116 and HT29 cell lines. In HCT116 and HT29 cells, CD133+CD44+ cells not only shared the extensive tumorigenic potential of LT-TICs but also functionally reproduced the behaviors of LT-TICs that drive tumor metastasis (TM) formation, suggesting that CD133+CD44+ cells are a typical representation of LT-TICs in colon cancer. Mechanistically, the enhanced capacity of CD133+CD44+ cells to drive metastasis involves the up-regulated expression of Wnt-, epithelial–mesenchymal transition (EMT)-, and metastasis-related genes in these cells. Additionally, CD133+CD44+ cells presented significant chemoresistance compared with corresponding nontumorigenic CD133−CD44− cells following exposure to oxaliplatin (OXLP) or 5-fluorouracil (5-FU). Accordingly, CD133+CD44+ cells contained lower reactive oxygen species (ROS) levels than CD1133−CD44− cells, and the low ROS levels in CD133+CD44+ cells were related to the enhancement of antioxidant defense systems. More importantly, CD133+CD44+ cells developed less DNA damage after exposure to chemotherapeutics than CD133−CD44− cells. In conclusion, we identified a subpopulation of LT-TICs in colon cancer.
Relationship between preterm, low birth weight and early childhood caries: a meta-analysis of the case–control and cross-sectional study
Authors: Shi Linan , Jia Jinhai , Li Chunnian , Zhao Caiyun , Li Ting , Shi Hong , Zhang Xiaolin 
Published: July 2020

AbstractEarly childhood caries (ECC) is one of the most prevalent chronic infectious diseases in children. The effective prevention and treatment are heavy burdens and study hotspots for pediatric dentists. Many studies had investigated the relationship between preterm, low birth weight (LBW) and ECC; however, the results were inconsistent. The present study was conducted with an evidence-based study to figure out the relationship between preterm, LBW and ECC for the first time. After searching the database, case–control and cross-sectional studies relevant to the relationship between preterm, LBW and ECC up to December 2019 were included. The data about odds ratio (OR) and 95% confidence interval (95% CI) were extracted and calculated with STATA 14.0 Software. A total of 22 studies were included in this meta-analysis, 9 studies of which did not only explore the relationship between ECC with preterm, but also study the relationship between ECC and LBW, 7 studies of which explored the relationship between preterm and ECC, and 6 studies of which studied the relationship between LBW and ECC. The meta-analysis results showed that the preterm increased the risk of ECC (OR = 1.59, 95% CI: 1.36–1.87) significantly. There was no difference between LBW and normal birth weight in the incidence of ECC (OR = 1.12, 95% CI: 0.94–1.33). The meta-analysis results of adjustment OR about LBW were similar to the crude OR (OR = 1.05, 95% CI: 0.71–1.57). This meta-analysis indicated that preterm increased the risk of ECC significantly; however, LBW was not a risk factor for ECC.
PEG3mutation is associated with elevated tumor mutation burden and poor prognosis in breast cancer
Authors: Zhang Min , Zhang Jin 
Published: July 2020

AbstractBackground: Breast cancer is the second most common malignancy in women and considered as a severe health burden. PEG3 mutations have been observed in several cancers. However, the associations of PEG3 mutation with tumor mutation burden (TMB) and prognosis in breast cancer have not been investigated. Methods: In our study, the somatic mutation data of 986 breast cancer patients from The Cancer Genome Atlas (TCGA) were analyzed. Results: It showed that PEG3 had a relatively high mutation rate (2%). After calculated the TMB in PEG3 mutant and PEG3 wild-type groups, we found the TMB value was significantly higher in PEG3 mutant samples than that in PEG3 wild-type samples (P = 5.6e-07), which was independent of the confounding factors including age, stage, mutations of BRCA1, BRCA2 and POLE (odd ratio, 0.45; 95% CI, 0.20–0.98; P=0.044). Survival analysis revealed that PEG3 mutant samples had inferior survival outcome compared with the PEG3 wild-type samples after adjusted for the confounding factors above (hazard ratio, 0.27; 95% CI: 0.12–0.57; P&lt;0.001). Conclusion: These results illustrated that PEG3 mutation was associated with high TMB and inferior prognosis, suggesting PEG3 mutation might play a guiding role in prognosis prediction and immunotherapy selection in breast cancer.
COVID-19 aus Sicht des Nephrologen
Authors: Kann Martin , Benzing Thomas 
Published: July 2020

AbstractIncreasing insight into the clinical phenotype and mechanisms of SARS-CoV-2 infections and COVID-19 has identified damage of the kidneys as a key player in the course of the disease. This manuscript summarizes the current knowledge on direct viral infection of kidney tissue, proteinuria and acute kidney injury in COVID-19, and management of patients on chronic dialysis as well as after kidney transplantation. Direct infection of podocytes and proximal tubular cells by SARS-CoV-2 has been confirmed and results in proteinuria and hematuria at an early stage of COVID-19. In this context, any kidney affection is a predictor of worse outcomes among COVID-19 patients irrespective of the initial presentation and increases the risk of acute kidney injury. Specific therapies for kidney damage and acute kidney injury within COVID-19 that could be generally recommended are currently lacking. Patients on chronic hemodialysis in particular are at risk for contracting SARS-CoV-2 infections as indicated by outbreaks and super-spreading events in hemodialysis facilities. Immunosuppressive therapy after kidney transplantation needs to be adapted upon diagnosis of COVID-19 depending on the severity of the initial presentation.
Endocavity Ultrasound Transducers: Why High-Level Disinfection Is Necessary
Authors: Westerway Susan Campbell , Basseal Jocelyne M. 
Published: July 2020

AbstractAs a medical imaging modality, ultrasound is used by a wide cross-section of practitioners including radiologists, obstetricians, gynecologists, gastroenterologists, urologists and cardiologists. The increasing popularity of ultrasound as a diagnostic tool is due not only to the ease of use and portability of systems, but also to the perceived safety aspect of the examination. This latter point needs to be examined. As with any reusable medical device, the ultrasound transducer, also known as a probe, could potentially be a vector for the transmission of pathogenic viruses and fungi between patients if not correctly disinfected after each use. This transmission risk is magnified for an endocavity transducer that has come in contact with the vagina, anal canal or oral cavity, as it could be contaminated with organisms transmitted by blood or mucosal, genital or rectal secretions. Based on the Spaulding system, transducers that come in contact with mucous membranes are classified as semi-critical devices that require high-level disinfection (HLD) after each patient procedure. This HLD process should eliminate all microorganisms except high numbers of bacterial endospores. Only a small number of countries worldwide have implemented transducer reprocessing guidelines that adhere to the Spaulding classification and recommend HLD for endocavity transducers. Overall, there is a lack of conformity among global health agencies regarding the use of HLD for endocavity transducers. This is primarily due to the perception that the infection transmission risk is negligible and that if an endocavity transducer has been covered with a single-use sheath for the procedure, then low-level disinfection provides sufficient protection against pathogen transmission. The objective of this study was to review the published risk of infection transmission from endocavity transducers. By highlighting the outbreaks and case reports that implicate pathogen transmission from transducers, we posit that HLD should be a global standard of practice for the reprocessing of endocavity transducers. It requires substantial time for national health administrations to develop and legislate new recommendations, and for practice changes to be accepted and implemented by healthcare providers. We recommend that Joint Commission International (JCI) and other equivalent organizations enforce the use of HLD of endocavity ultrasound transducers during their accreditation reviews.
Codonopsis lanceolata Contributes to Ca2+ Homeostasis by Mediating SOCE and PLC/IP3 Pathways in Vascular Endothelial and Smooth Muscle Cells
Authors: Kim Min Kyung , Han A Young , Shin You Kyoung , Lee Kwang-Won , Seol Geun Hee 
Published: July 2020

Abstract
Codonopsis lanceolata has been widely used as an anti-inflammatory and anti-lipogenic agent in traditional medicine. Recently, C. lanceolata was reported to prevent hypertension by improving vascular function. This study evaluated the effects of C. lanceolata and its major component lancemaside A on cytosolic calcium concentration in vascular endothelial cells and vascular smooth muscle cells. Cytosolic calcium concentration was measured using fura-2 AM fluorescence. C. lanceolata or lancemaside A increased the cytosolic calcium concentration by releasing Ca2+ from the endoplasmic reticulum and sarcoplasmic reticulum and by Ca2+ entry into endothelial cells and vascular smooth muscle cells from extracellular sources. The C. lanceolata- and lancemaside A-induced cytosolic calcium concentration increases were significantly inhibited by lanthanum, an inhibitor of non-selective cation channels, in both endothelial
cells and vascular smooth muscle cells. Moreover, C. lanceolata and lancemaside A significantly inhibited store-operated Ca2+ entry under pathological extracellular Ca2+ levels. In Ca2+-free extracellular fluid, increases in the cytosolic calcium concentration induced by C. lanceolata or lancemaside A were significantly inhibited by U73122, an inhibitor of phospholipase C, and 2-APB, an inositol 1,4,5-trisphosphate receptor antagonist. In addition, dantrolene treatment, which inhibits Ca2+ release through ryanodine receptor channels, also inhibited C. lanceolata- or lancemaside A-induced increases in the cytosolic calcium concentration through the phospholipase C/inositol 1,4,5-trisphosphate pathway. These results suggest that C. lanceolata and lancemaside A increase the cytosolic calcium concentration through the non-selective cation channels and phospholipase C/inositol 1,4,5-trisphosphate pathways
under physiological conditions and inhibit store-operated Ca2+ entry under pathological conditions in endothelial cells and vascular smooth muscle cells. C. lanceolata or lancemaside A can protect endothelial cells and vascular smooth muscle cells by maintaining cytosolic calcium concentration homeostasis, suggesting possible applications for these materials in diets for preventing vascular damage.
Asymptomatic Presacral Paraganglioma: Management of an Unpredictable Intraoperative Finding
Authors: Samara Athina A. , Diamantis Alexandros , Symeonidis Dimitrios , Anagnostou Athanasios , Diamantis Andreas Marios , Mavrovounis Georgios , Tepetes Konstantinos 
Published: August 2020

AbstractParagangliomas are rare neuroendocrine tumors originating from the embryological neural crest. We report a rare case of a patient with an asymptomatic presacral mass (incidentaloma) who experienced an unpredictable intraoperative hypertensive crisis after manipulation of the tumor. Presacral neoplasms pose a diagnostic and therapeutic challenge due to their obscure anatomical location and the difficulty in performing an R0 excision. Furthermore, the management of asymptomatic paragangliomas requires a high level of clinical suspicion and expertise due to potential life-threatening intraoperative complications.
Safety of Interhospital ECMO Transport by Low-Volume ECMO Transport Centers
Authors: Singh Kalpana , Ojito Jorge , Sasaki Jun 
Published: July 2020

AbstractWe present our 20 years of experience as a low-volume extracorporeal membrane oxygenation (ECMO) transport center from the Southeast United States. This is a retrospective chart review of all ECMO transported patients between 1998 and 2017. Of 26 patients who were ECMO transported, median age was 15.5 days, 14 patients (54%) were neonates, 18 (69%) patients had primary cardiac pathologies, and 16 (61.5%) patients had primary ECMO transport. Median distance traveled was 81 miles. All patients were on venoarterial ECMO. Complications occurred in three patients (11.5%). Survival to discharge was 69%. Neonatal and pediatric ECMO transport by a low-volume ECMO transport center is safe.
Validity and usefulness of COVID-19 models
Authors: Eker Sibel 
Published: August 2020

AbstractMathematical models have become central to the public and policy debate about the recent COVID-19 pandemic. On the one hand, they provide guidance to policy-makers about the development of the epidemic and healthcare demand overtime; on the other hand, they are heavily criticized for their lack of credibility. This commentary reflects on three such models from a validity and usefulness perspective. Specifically, it discusses the complexity, validation, and communication of models informing the government decisions in the UK, US and Austria, and concludes that, although these models are useful in many ways, they currently lack a thorough validation and a clear communication of their uncertainties. Therefore, prediction claims of these models should be taken cautiously, and their merits on scenario analysis should be the basis for decision-making. The lessons that can be learned from the COVID models in terms of the communication of uncertainties and assumptions can guide the use of quantitative models in other policy-making areas.
Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination
Authors: He Yafeng , Ren Jianke , Xu Xiaoping , Ni Kai , Schwader Andrew , Finney Richard , Wang Can , Sun Lei , Klarmann Kimberly , Keller Jonathan , Tubbs Anthony , Nussenzweig Andre , Muegge Kathrin 
Published: July 2020

SignificanceICF4 is an inherited disease with early mortality due to immunodeficiency. Although the genetic cause is known to be a mutation in the Lsh (lymphoid-specific helicase) gene, it remains unknown why patients suffer from an impaired immune response. Using conditional Lsh knockout mouse models, we provide evidence that Lsh has a hematopoietic cell-intrinsic role in promoting early B cell development and that deficient B cells fail to conduct the step of DNA end joining that is required to yield a variety of immunoglobulin isotypes during class switch recombination. Our data uncover an essential role of Lsh/HELLS in immunoglobulin production which could lead to improved therapeutic options to treat ICF4 patients.
Study of analog performance of common source amplifier using rectangular core–shell based double gate junctionless transistor
Authors: Narula Vishal , Agarwal Mohit 
Published: July 2020

Abstract
A new state of the art double gate junctionless transistor (DGJLT) namely the rectangular core–shell DGJLT (RCS-DGJLT) based common source amplifier circuit is designed to investigate the performance. An RCS-DGJLT device is designed using a visual technology computer aided design tool and look up table-based Verilog-A model has been designed to carry out spice simulation of the circuit. Device simulation of RCS-DGJLT shows the extraordinary performance when compared to conventional DGJLT. The RCS-DGJLT exhibits an OFF current (Ioff
) ∼10−14 A, ON current (Ion
) ∼10−5 A, ON/OFF current ratio (Ion
/Ioff
) ∼109, subthreshold slope ∼68.9 mV decade−1 and drain induced barrier lowering ∼52.6 mV V−1. Also, the AC response of RCS-DGJLT exhibits good performance like lower miller capacitances of order 10–16 F, maximum unity gain frequency of 138.8 GHz, transconductance generation efficiency of 40 V−1, and gain-bandwidth product of 25.4 GHz. The common source amplifier circuit using RCS-DGJLT provides the amplification up to 3.3 times which implies gain (Av
) to be 3.3. The low leakage power of 10.4 pW and average power of 31.2 µW of common source amplifier circuit based on RCS-DGJLT shows the greater potential of using the proposed device in analog applications. Also, the complete flow chart of the process used to design an analog circuit based on proposed RCS-DGJLT is discussed. The result shows the potential of using the RCS-DGJLT device in designing high-frequency applications.
Self-foldable origami reflector antenna enabled by shape memory polymer actuation
Authors: Jape Sameer , Garza Milton , Ruff Joshua , Espinal Francisco , Sessions Deanna , Huff Gregory , Lagoudas Dimitris C , Peraza Hernandez Edwin A , Hartl Darren J 
Published: July 2020

Abstract
This paper presents the design, fabrication, and characterization of a self-foldable Active Origami Reflector Antenna (AORA) of parabolic form. Self-folding of the AORA is enabled by smooth uncreased folds composed of shape memory polymer (SMP) composites. Design methods for origami with smooth folds are applied to determine the shape and fold pattern of a planar sheet that can be folded to reach the parabolic antenna shape. A proof-of-concept prototype of the AORA is fabricated and self-folding of the AORA driven by thermal actuation of the SMP composite folds is demonstrated. The far-field electromagnetic (EM) characteristics of the AORA prototype are investigated through numerical simulations and experimental measurements in an anechoic chamber. A design-of-experiment study is conducted to investigate the effects of the antenna shape parameters on its EM characteristics such as far-field antenna gain and beamwidth, and to compare the performance of the AORA to that of equivalent smooth and faceted parabolic reflectors. Applications of the AORA include high-gain directional radio telescopes and satellite telecommunication.