bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors related to the use of opioids as early treatment in patients with knee osteoarthritis
Authors: Cho Soo-Kyung , Jung Sun-Young , Choi Seongmi , Im Seul Gi , Kim Hyoungyoung , Choi Woo Seok , Jang Eun Jin , Sung Yoon-Kyoung 
Published: November 2019

Abstract

Objective
To examine factors related to the use of opioids as an early treatment option for knee OA patients

Methods
Using the Korean nationwide claim database, we selected knee OA patients between 2013 and 2015. Among them, patients without any claim of knee OA for 2 years before the index date were included as our study population. We analyzed their first claim for prescriptions, including tramadol and stronger opioids, at the index date of each patient. Using a multinomial model, we identified factors associated with the early use of tramadol and stronger opioids in knee OA patients.

Results
Among a total of 2,857,999 knee OA patients, 12.2% (n = 348,516) were treated with opioids as their first treatment. However, the prevalence of stronger opioid use was only 0.07% (n = 1972). Male sex (OR 1.28 in tramadol, OR 1.13 in stronger opioids) and comorbidities with depression (OR 1.05, 1.46), low back pain (OR 1.13, 1.30), intervertebral disc disorder (OR 1.11, 1.40), and spinal stenosis (OR 1.27, 1.55) were the factors for the early use of tramadol or stronger opioids in knee OA patients. Patients in a tertiary referral hospital tended to use tramadol or stronger opioids than those in clinics (OR 1.04, 56.63, respectively).

Conclusion
In Korea, 12.2% of knee OA patients were treated with opioids as an early treatment, and tramadol was used more commonly than stronger opioids. Male sex and having comorbidities such as depression or musculoskeletal disease are patient factors associated with the early use of opioids in knee OA patients.
Validity of simplified, calibration-less exercise intensity measurement using resting heart rate during sleep: a method-comparison study with respiratory gas analysis
Authors: Matsuura Hirotaka , Mukaino Masahiko , Otaka Yohei , Kagaya Hitoshi , Aoshima Yasushi , Suzuki Takuya , Inukai Ayaka , Hattori Emi , Ogasawara Takayuki , Saitoh Eiichi 
Published: November 2019

AbstractBackgroundThe recent development of wearable devices has enabled easy and continuous measurement of heart rate (HR). Exercise intensity can be calculated from HR with indices such as percent HR reserve (%HRR); however, this requires an accurate measurement of resting HR, which can be time-consuming. The use of HR during sleep may be a substitute that considers the calibration-less measurement of %HRR. This study examined the validity of %HRR on resting HR during sleep in comparison to percent oxygen consumption reserve (%VO2R) as a gold standard. Additionally, a 24/7%HRR measurement using this method is demonstrated.MethodsTwelve healthy adults aged 29 ± 5 years underwent treadmill testing using the Bruce protocol and a 6-min walk test (6MWT). The %VO2R during each test was calculated according to a standard protocol. The %HRR during each exercise test was calculated either from resting HR in a sitting position (%HRRsitting), when lying awake (%HRRlying), or during sleep (%HRRsleeping). Differences between %VO2R and %HRR values were examined using Bland-Altman plots. A 180-day, 24/7%HRR measurement with three healthy adults was also conducted. The %HRR values during working days and holidays were compared.ResultsIn the treadmill testing, the mean difference between %VO2R and %HRRsleepingwas 1.7% (95% confidence interval [CI], − 0.2 to 3.6%). The %HRRsittingand %HRRlyingvalues were 10.8% (95% CI, 8.8 to 12.7%) and 7.7% (95% CI, 5.4 to 9.9%), respectively. In the 6MWT, mean differences between %VO2R and %HRRsitting, %HRRlyingand %HRRsleepingwere 12.7% (95% CI, 10.0 to 15.5%), 7.0% (95% CI, 4.0 to 10.0%) and − 2.9% (95% CI, − 5.0% to − 0.7%), respectively. The 180-day, 24/7%HRR measurement presented significant differences in %HRR patterns between working days and holidays in all three participants.ConclusionsThe results suggest %HRRsleepingis valid in comparison to %VO2R. The results may encourage a calibration-less, 24/7 measurement model of exercise intensity using wearable devices.Trial registrationUMIN000034967.Registered 21 November 2018 (retrospectively registered).
European Training Assessment Programme 2.0
Authors:   European Board of Radiology (EBR)
Published: November 2019

Abstract
The European Training Assessment Programme (ETAP) 2.0 offers a structured assessment of radiology training institutions applying for certification, without geographical constraints. It applies, in fact, to both European and non-European institutions, which fulfill the eligibility criteria and wish to obtain a European certification.
ETAP 2.0 aims to provide centres that offer specialty training in radiology with an objective assessment by external assessors of their training programmes. ETAP 2.0 also aims to develop assessment systems and guidelines to be used by postgraduate education authorities at a national level.
The online evaluation system facilitates the application process as well as the assessment and subsequent certification. The platform enables users – both representatives of applicant institutions and assessors – to easily and efficiently store, access, and manage documents and information at any time, thereby facilitating the certification process.
New insulin delivery devices and glycemic outcomes in young patients with type 1 diabetes: a protocol for a systematic review and meta-analysis
Authors: Dos Santos Tiago Jeronimo , Donado Campos Juan de Mata , Fraga Medin Cristina Alexandra , Argente Jesús , Rodríguez-Artalejo Fernando 
Published: November 2019

Abstract

Background
Optimal type 1 diabetes mellitus (T1D) care requires lifelong appropriate insulin treatment, which can be provided either by multiple daily injections (MDI) of insulin or by continuous subcutaneous insulin infusion (CSII). An increasing number of trials and previous systematic reviews and meta-analyses (SRMA) have compared both CSII and MDI but have provided limited information on equity and fairness regarding access to, and the effect of, those insulin devices. This study protocol proposes a clear and transparent methodology for conducting a SRMA of the literature (1) to assess the effect of CSII versus MDI on glycemic and patient-reported outcomes (PROs) among young patients with T1D and (2) to identify health inequalities in the use of CSII.

Methods
This protocol was developed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P), the PRISMA-E (PRISMA-Equity 2012 Guidelines), and the Cochrane Collaboration Handbook. We will include randomized clinical trials and non-randomized studies published between January 2000 and June 2019 to assess the effectiveness of CSII versus MDI on glycemic and PROs in young patients with T1D. To assess health inequality among those who received CSII, we will use the PROGRESS framework. To gather relevant studies, a search will be conducted in MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), the Cochrane Database of Systematic Reviews, and the Health Technology Assessment (HTA) database. We will select studies that compared glycemic outcomes (the glycosylated hemoglobin values, severe hypoglycemia episodes, diabetic ketoacidosis events, and/or time spent in range or in hyper-hypoglycemia), and health-related quality of life, as a PRO, between therapies. Screening and selection of studies will be conducted independently by two researchers. Subgroup analyses will be performed according to age group, length of follow-up, and the use of adjunctive technological therapies that might influence glycemic outcomes.

Discussion
Studies of the average effects of CSII versus MDI may have not assessed their impact on health equity, as some intended populations have been excluded. Therefore, this study will address health equity issues when assessing effects of CSII. The results will be published in a peer-review journal. Ethics approval will not be needed.

Systematic review registration
PROSPERO CRD42018116474
Equivalent properties of a reverse half-discrete Hilbert’s inequality
Authors: Wang Ai-zhen , Yang Bi-cheng , Chen Qiang 
Published: November 2019

AbstractBy using the weight functions, the idea of introduced parameters and the Euler–Maclaurin summation formula, a reverse half-discrete Hilbert’s inequality with the homogeneous kernel and the reverse equivalent forms are given (for${p<0}$p<0,${0< q<1}$0<q<1). The equivalent statements of the best possible constant factor related to a few parameters are considered. As applications, two corollaries about the case of the non-homogeneous kernel and some particular cases are obtained.
Naturally occurring Piper plant amides potential in agricultural and pharmaceutical industries: perspectives of piperine and piperlongumine
Authors: Jeon Hwang-Ju , Kim Kyeongnam , Kim Yong-Deuk , Lee Sung-Eun 
Published: November 2019

Abstract
Piperaceae plants consist of about 3600 species, of which about 2000 are Piper plants. Their habitat is distributed across pantropical regions. The representative plant is Piper nigrum, known as black pepper. These plants have been widely used in folk medicine in Korean traditional medicine. This review collected papers identifying and separating the amides obtained from these Piper plants, with a focus on Piper amides potential to control the production and growth of fungal strains that cause plant disease and their insecticidal properties against agricultural pests. Piper amide benefits include antiaflatoxigenic activities, antiparasitic activities, anticancer properties, antiplatelet activities, and anti-inflammatory activities, among other therapeutic properties for the treatment of human diseases. In addition, this review paper provides a total synthesis study on the mass production of Piper amides and their derivatives, with a formulation study for industrial use. This review paper is designed to help inform future studies on Piper amide applications.
Heat stress affects fecal microbial and metabolic alterations of primiparous sows during late gestation
Authors: He Jianwen , Guo Huiduo , Zheng Weijiang , Xue Yongqiang , Zhao Ruqian , Yao Wen 
Published: November 2019

Abstract

Background
Heat stress (HS) jeopardizes intestinal barrier functions and augments intestinal permeability in pigs. However, whether HS-induced maternal microbial and metabolic changes in primiparous sows during late gestation remains elusive. We present here, a study investigating the fecal microbial and metabolic responses in late gestational primiparous sows when exposed to HS.

Methods
Twelve first-parity Landrace × Large White F1 sows were randomly assigned into two environmental treatments including the thermoneutral (TN) (18–22 °C; n = 6) and HS (28–32 °C; n = 6) conditions. Both treatments were applied from 85 d of gestation to farrowing. The serum and feces samples were collected on d 107 of gestation, for analyses including intestinal integrity biomarkers, high-throughput sequencing metagenomics, short-chain fatty acid (SCFA) profiles and nontargeted metabolomics.

Results
Our results show that HS group has higher serum Heat shock protein 70 (HSP70), lipopolysaccharide (LPS) and lipopolysaccharide-binding protein (LBP) levels. The gut microbial community can be altered upon HS by using β-diversity and taxon-based analysis. In particular, the relative abundance of genera and operational taxonomic units (OTUs) related to Clostridiales and Halomonas are higher in HS group, the relative abundance of genera and OTUs related to Bacteroidales and Streptococcus, however, are lower in HS group. Results of metabolic analysis reveal that HS lowers the concentrations of propionate, butyrate, total SCFA, succinate, fumarate, malate, lactate, aspartate, ethanolamine, β-alanine and niacin, whereas that of fructose and azelaic acid are higher in HS group. These metabolites mainly affect propanoate metabolism, alanine, aspartate and glutamate metabolism, phenylalanine metabolism, β-alanine metabolism, pantothenate and CoA biosynthesis, tricarboxylic acid cycle (TCA) and nicotinate and nicotinamide metabolism. Additionally, correlation analysis between significant microbes and metabolites indicated that the HS-induced microbiota shift is likely the cause of changes of intestinal metabolism.

Conclusions
Taken together, we reveal characteristic structural and metabolic changes in maternal gut microbiota as a result of late gestational HS, which could potentially provide the basis for further study on offspring gut microbiota and immune programming.
Short group psychoeducation followed by daily electronic self-monitoring in the long-term treatment of bipolar disorders: a multicenter, rater-blind, randomized controlled trial
Authors: Petzold Johannes , Mayer-Pelinski René , Pilhatsch Maximilian , Luthe Susan , Barth Thomas , Bauer Michael , Severus Emanuel 
Published: November 2019

Abstract
Background
Despite various pharmacological and psychological treatment interventions, bipolar disorders rank among the leading causes of global disease burden. Group psychoeducation has been demonstrated an effective add-on to pharmacotherapy, but it may be difficult to implement in practice depending on the clinical setting and available human resources.

Methods
Multicenter, rater-blind, randomized controlled trial to investigate the efficacy of a new intervention program consisting of an initial 6-week psychoeducation protocol plus a subsequent structured daily computer-based self-charting program (ChronoRecord) over 54 weeks in remitted patients with bipolar disorders. The control condition included non-structured group sessions followed by daily computer-based self-reports (unstructured like a diary). Both groups received treatment-as-usual.

Results
Over 2 years, 41 mood episodes occurred in the experimental group (n = 39) compared to 27 in the control group (n = 34), without reaching statistical significance. Time to recurrence did not significantly differ between the experimental and control group (25% relapsed after 112 and 273 days, respectively). There were no significant group-by-time interactions in mood symptoms, quality of life, self-efficacy expectations or perceived involvement in care.

Conclusions
Six weekly psychoeducational group sessions followed by daily self-monitoring via ChronoRecord for 54 weeks may not be superior to non-structured group meetings followed by unstructured self-reporting. Other psychotherapeutic interventions may be needed to optimize the treatment of patients with bipolar disorders, especially for those at later disease stages.
Trial registration Retrospectively registered at German Clinical Trials Register on May 24, 2019; DRKS00017319
BRAF V600E mutation in Juvenile Xanthogranuloma family neoplasms of the central nervous system (CNS-JXG): a revised diagnostic algorithm to include pediatric Erdheim-Chester disease
Authors: Picarsic J. , Pysher T. , Zhou H. , Fluchel M. , Pettit T. , Whitehead M. , Surrey L. F. , Harding B. , Goldstein G. , Fellig Y. , Weintraub M. , Mobley B. C. , Sharples P. M. , Sulis M. L. , Diamond E. L. , Jaffe R. , Shekdar K. , Santi M. 
Published: November 2019

AbstractThe family of juvenile xanthogranuloma family neoplasms (JXG) with ERK-pathway mutations are now classified within the “L” (Langerhans) group, which includes Langerhans cell histiocytosis (LCH) and Erdheim Chester disease (ECD). Although theBRAFV600E mutation constitutes the majority of molecular alterations in ECD and LCH, only three reported JXG neoplasms, all in male pediatric patients with localized central nervous system (CNS) involvement, are known to harbor theBRAFmutation. This retrospective case series seeks to redefine the clinicopathologic spectrum of pediatric CNS-JXG family neoplasms in the post-BRAF era, with a revised diagnostic algorithm to include pediatric ECD. Twenty-two CNS-JXG family lesions were retrieved from consult files with 64% (n = 14) having informativeBRAFV600E mutational testing (molecular and/or VE1 immunohistochemistry). Of these, 71% (n = 10) were pediatric cases (≤18 years) and half (n = 5) harbored theBRAFV600E mutation. As compared to theBRAFwild-type cohort (WT), theBRAFV600E cohort had a similar mean age at diagnosis [BRAF V600E: 7 years (3–12 y), vs. WT: 7.6 years (1–18 y)] but demonstrated a stronger male/female ratio (BRAF V600E: 4 vs WT: 0.67), and had both more multifocal CNS disease ( BRAFV600E: 80% vs WT: 20%) and systemic disease (BRAF V600E: 40% vs WT: none). Radiographic features of CNS-JXG varied but typically included enhancing CNS mass lesion(s) with associated white matter changes in a subset ofBRAFV600E neoplasms. After clinical-radiographic correlation, pediatric ECD was diagnosed in theBRAFV600E cohort. Treatment options varied, including surgical resection, chemotherapy, and targeted therapy with BRAF-inhibitor dabrafenib in one mutated case.BRAFV600E CNS-JXG neoplasms appear associated with male gender and aggressive disease presentation including pediatric ECD. We propose a revised diagnostic algorithm for CNS-JXG that includes an initial morphologic diagnosis with a final integrated diagnosis after clinical-radiographic and molecular correlation, in order to identify cases of pediatric ECD. Future studies with long-term follow-up are required to determine if pediatricBRAFV600E positive CNS-JXG neoplasms are a distinct entity in the L-group histiocytosis category or represent an expanded pediatric spectrum of ECD.
Association between dexmedetomidine use for the treatment of alcohol withdrawal syndrome and intensive care unit length of stay
Authors: Yavarovich Ekaterina R. , Bintvihok Maythawee , McCarty Justin C. , Breeze Janis L. , LaCamera Peter 
Published: November 2019

AbstractPurposeAlcohol withdrawal syndrome (AWS) is commonly treated in medical ICUs and typically requires high resource utilization. Dexmedetomidine for AWS has not been extensively investigated, and guidelines regarding its use are lacking. We evaluated the association between dexmedetomidine use in AWS and ICU length of stay (LOS).MethodsWe performed a multi-institutional retrospective cohort study of patients in the ICU with the primary diagnosis of AWS. ICU LOS of those treated with benzodiazepines alone vs. benzodiazepines plus dexmedetomidine was compared. Negative binomial regression was performed to test whether dexmedetomidine use was associated with increased ICU LOS after adjustment for age, gender, body mass index, and the time between hospital and ICU admission.ResultsFour hundred thirty-eight patients from eight institutions were included. Patients treated with benzodiazepines plus dexmedetomidine had higher Clinical Institute Withdrawal Assessment for Alcohol scores at ICU admission, spent longer on the medical wards prior to ICU admission, and had longer unadjusted ICU LOS (p < 0.0001). After covariate adjustment, dexmedetomidine remained associated with longer ICU LOS (relative mean to non-dexmedetomidine group 2.14, 95% CI 1.78–2.57,p < 0.0001).ConclusionsCompared to benzodiazepines alone, dexmedetomidine for the treatment of AWS was associated with increased ICU LOS. These results provide evidence that dexmedetomidine may increase resource utilization.
Local application of doxorubicin- loaded Iron oxid nanoparticles and the vascular disrupting agent via the hepatic artery: chemoembolization–photothermal ablation treatment of hepatocellular carcinoma in rats
Authors: Yuan Hongjun , Li Xin , Tang Jing , Zhou Min , Liu Fengyong 
Published: November 2019

Abstract

Objectives
This study investigates the effectiveness of local application of doxorubicin(Dox)-loaded, polydopamine (PDA)- coated single crystal hematite (α- Fe2O3) nanocubes (Fe2O3-PDA-Dox) and combretastatin A-4 phosphate disodium(CA4P)in treating hepatocellular carcinoma (HCC) in rats.

Methods
The magnetic characteristics and photothermal effects of the nanoparticles were determined in vitro. Tumor-bearing Sprague–Dawley rats were divided into 3 groups of 8 according to treatment: controls, transarterial chemoembolization–photothermal ablation (pTACE) (Lipidol+Fe2O3-PDA-Dox + NIR), and CA4P + pTACE (CA4P+ Lipidol+Fe2O3-PDA-Dox + NIR). Drugs were administered through the hepatic artery, and the tumors exposed to 808-nm near-infrared radiation. The Fe content of tumors was assessed using neutron activation analysis. Treatment effectiveness was assessed using heating curves, magnetic resonance imaging, pathology results, and immunohistochemical analysis.

Results
The mean tumor Fe content was greater in rats treated with CA4P + pTACE (1 h, 23.72 ± 12.45 μg/g; 24 h, 14.61 ± 8.23 μg/g) than in those treated with pTACE alone (1 h, 5.66 ± 4.29 μg/g; 24 h, 2.76 ± 1.33 μg/g). The tumor T2 imaging signal was lower in rats treated with CA4P + pTACE. Following laser irradiation, the tumor temperature increased, with higher temperatures reached in the CA4P + pTACE group (62 °C vs 55 °C). Tumor cells exhibited necrosis, apoptosis, and proliferation inhibition, with greater effects in the CA4P + pTACE group. Transient liver and kidney toxicity were observed on day 3, with more severe effects after CA4P + pTACE.

Conclusions
Fe2O3-PDA-Dox nanoparticles are effective for TACE–PTA. Pretreatment with CA4P increases nanoparticle uptake by tumors, increasing the treatment effectiveness without increasing hepatorenal toxicity.
Inclination of houses induced by liquefaction in the 2018 Hokkaido Iburi-tobu earthquake, Japan
Authors: Serikawa Yuko , Miyajima Masakatsu , Yoshida Masaho , Matsuno Kenji 
Published: November 2019

Abstract

Background
On September 6th, 2018, at 3:07 local time, a strong earthquake of magnitude Mw = 6.6 struck the east Iburi region in Hokkaido, Japan. Many serious damages such as landslide, liquefaction and collapse of houses occurred from this earthquake. Liquefaction caused road deformation and inclination of houses in Sapporo city, Hokkaido. In order to understand the damage caused by the earthquake, and find a solution to mitigate the liquefaction-induced damage in Sapporo city, a preliminary investigation of the 2018 Hokkaido Iburi-tobu earthquake was conducted from 18 to 20 September 2018.

Results
The damages to the houses at Satozuka town and Utsukushigaoka town in Sapporo city are focused on. The damage at Satozuka was so enormous that the residents could not continue to live in their houses. Although the inclination of houses can be seen by visual inspection at Satozuka, there were few houses where the inclination can be judged visually at Utsukushigaoka. Therefore we did a field survey of inclined houses by using a digital angle meter at Utsukushigaoka.

Conclusions
The inclination of 57 houses at Utsukushigaoka was measured, and the maximum value and direction of inclination are shown on the map. The houses located at the reclaimed land of the former river and former valley plain were inclined. Therefore, the old terrain greatly affected to the inclination of houses. These liquefaction-induced damage occurred in the same area where liquefaction occurred during the 2003 Tokachi-oki earthquake.