bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poleward Shift of the Kuroshio Extension Front and Its Impact on the North Pacific Subtropical Mode Water in the Recent Decades
Authors: Wu Baolan , Lin Xiaopei , Yu Lisan 
Published: November 2020

AbstractThe meridional shift of the Kuroshio Extension (KE) front and changes in the formation of the North Pacific Subtropical Mode Water (STMW) during 1979–2018 are reported. The surface-to-subsurface structure of the KE front averaged over 142°–165°E has shifted poleward at a rate of ~0.23° ± 0.16° decade−1. The shift was caused mainly by the poleward shift of the downstream KE front (153°–165°E, ~0.41° ± 0.29° decade−1) and barely by the upstream KE front (142°–153°E). The long-term shift trend of the KE front showed two distinct behaviors before and after 2002. Before 2002, the surface KE front moved northward with a faster rate than the subsurface. After 2002, the surface KE front showed no obvious trend, but the subsurface KE front continued to move northward. The ventilation zone of the STMW, defined by the area between the 16° and 18°C isotherms or between the 25 and 25.5 kg m−3 isopycnals, contracted and displaced northward with a shoaling of the mixed layer depth hm before 2002 when the KE front moved northward. The STMW subduction rate was reduced by 0.76 Sv (63%; 1 Sv ≡ = 106 m3 s−1) during 1979–2018, most of which occurred before 2002. Of the three components affecting the total subduction rate, the temporal induction (−∂hm/∂t) was dominant accounting for 91% of the rate reduction, while the vertical pumping (−wmb) amounted to 8% and the lateral induction (−umb ⋅ ∇hm) was insignificant. The reduced temporal induction was attributed to both the contracted ventilation zone and the shallowed hm that were incurred by the poleward shift of KE front.
Composite phase change materials improve the photo-thermal effects of cotton fabrics
Authors: Zhang Wei , Hao Shang , Weng Jiali , Zhang Yibo , Yao Jiming , Wei Sainan 
Published: November 2020

We report on the impregnation-based preparation of composite phase change materials (CPCMs) with thermal storage properties, using paraffin wax and multi-walled carbon nanotubes (MWCNTs). We coated the CPCMs on the fabric by scraper coating, then evaluated their shape stability, latent heat, thermal conductivity, thermal storage stability and photo-thermal effects. Results show that CPCMs with 10% acid-oxidized MWCNTs introduce only a small phase leakage when heated at 50℃ for 900 s; their latent heat energy reduces by 16.5%, while their thermal conductivity increases by 131.9% compared to pure paraffin. When exposed to sunlight at an ambient temperature of 12.5℃, the cotton fabrics coated with CPCMs record a 12.8℃ higher surface temperature than the pristine fabric, while their heat dissipation is delayed by 120–180 s. The fabric surface temperature increases to twice the ambient temperature during daytime. Overall, these findings indicate that the coated fabric has excellent thermal stability, affirming its potential as photo-thermal functional material.
Contesting Mexico’s Necropolitics: Necrogovernance and Subversive Necropower in Two Cases
Authors: Ohlson Olof 
Published: November 2020

Mexico’s contentious necropolitics see different stakeholders involved in political struggles for control over the dead. The families of victims of state and corporate violence protest state necrogovernance and corporate necropower, the power to dictate the circumstances of citizens’ and workers’ lives and deaths. Two case studies show how the state and corporations deploy the criminal technique of disappearing bodies as a means of social control and rendering workers expendable and sometimes killable. Social movements counter this with a determined struggle to restore a sense of worth to the victims of violence through public mourning. Their repertoire of collective action has created a subversive necropower that challenges both necrogovernance and corporate necropower. La contenciosa necropolítica de México involucra a distintos grupos de interés que participan en la contienda política por el control de los muertos. Las familias de las víctimas de la violencia de Estado y corporativa protestan contra la necrogobernanza estatal y la necropotencia corporativa, y du poder de dictaminar las circunstancias de vida y muerte de los ciudadanos y trabajadores. Dos estudios de caso muestran cómo el Estado y las corporaciones despliegan la técnica criminal de desaparecer los cuerpos como un medio de control social que hace a los trabajadores prescindibles y a veces matables. Los movimientos sociales responden con una lucha decidida por restaurar un sentido de valor para las víctimas de la violencia a través del duelo público. Su repertorio de acción colectiva ha creado una necropotencia subversiva que desafía tanto a la necrogobernanza como a la necropotencia corporativa.
Comparison of a perfusion simulator to a clinical operating room: evaluation of eye tracking data and subjective perception. A pilot study
Authors: Pawelke Cynthia , Merkle Frank , Kurtovic Dino , Gierig Sina , Müller-Plath Gisela 
Published: November 2020

Background: With the aim of evaluating the perfusion simulator at the German Heart Center Berlin, similarity between simulation and clinical operation room (OR) was investigated regarding subjective perception and eye movement. Methods: Eight perfusionists performed an operation on the heart-lung machine (HLM) wearing eye tracking glasses, each in real OR and simulator. The three most important phases for perfusionists (going on bypass, cardioplegia administration and coming off bypass) were considered. Additional to eye tracking data as objective measure, questionnaires were completed, and interviews conducted afterwards. Results: The structure of simulator and real OR is perceived as basically the same. Yet there are differences in the HLM-models used and the temporal sequence. Different perception of both situations is reported in interviews and reflected in significant differences in the rating scales (NASA-TLX) on three of six subscales. In eye tracking data, certain AOIs could be identified for the individual phases, both in OR and simulator—an indication of fundamental similarity. However, differences regarding the proportions of the individual AOIs, especially in the first and third phase, are leading to the assumption that the simulator, and especially the simulation process, is only valid to a limited extent regarding subjective perception and eye tracking data. Conclusion: The use of the simulator for (advanced) training is accepted and explicitly requested by perfusionists. Yet further research is needed to identify the decisive factors (like simulation duration or additional tasks) for a valid execution in the simulator. Furthermore, a larger sample size should be regarded to allow statistical analysis.
Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change in RCAN1 expression
Authors: Shuo Wang , Li Haicong , Muneko Nishijo , Yoshikazu Nishino , Kato Nobuo , Kasamaki Yuji , Ueda Tadashi , Kanda Tsugiyasu 
Published: November 2020

Objective Regulator of calcineurin 1 (RCAN1) controls plasticity of the nervous system and depressive conditions by regulating brain-derived neurotropic factor (BDNF) and plays a crucial role in neural and cardiac pathways. The apolipoprotein E gene ( ApoE) is a robust risk factor for progression of Alzheimer’s disease. A fatty diet is considered detrimental for metabolic disorders, such as obesity and cardiovascular diseases. Methods We examined the neuronal and cardiac protective roles of RCAN1 in ApoE−/− mice that were fed a high- or low-fat diet with and without voluntary movement for 3 months. Organ weights, laboratory data, histology, RNA expression, and behavior were examined. Results A high-fat diet with exercise improved depressive function, as examined by the forced swimming test, and RCAN1 mRNA expression was induced in the hippocampus. A low-fat diet with exercise resulted in a reduced body weight, higher heart weight/body weight ratio, and lower circulating triglyceride levels compared with a low-fat diet without exercise. RCAN1 mRNA expression was increased in cardiomyocytes in ApoE−/− mice. Conclusions The combination of a high-fat diet and exercise might reduce depressive function, whereas a low-fat diet with exercise leads to cardioprotection. Induction of RCAN1 expression might affect neuroplasticity and cardiac function.
Meta-analysis of postoperative antithrombotic therapy after left atrial appendage occlusion
Authors: Li Shu-yue , Wang Juan , Hui Xiang , Zhu Huai-jun , Wang Bao-yan , Xu Hang 
Published: November 2020

Objective This meta-analysis explored the safety and effectiveness of different anticoagulant regimens after left atrial appendage occlusion (LAAO). Methods Databases, such as PubMed, MEDLINE, EMBASE, Web of Science, and Cochrane Library, were searched to identify eligible studies according to the inclusion criteria. The incidences of events, including device-related thrombus (DRT) formation, stroke, systemic thromboembolism, bleeding, cardiovascular mortality, and all-cause mortality, were analyzed using R version 3.2.3. Results The screening retrieved 32 studies, including 36 study groups and 4,474 patients. The incidence of outcomes after LAAO was calculated via meta-analysis. In the subgroup analysis, the rates of DRT formation, cardiovascular mortality, and all-cause mortality were significantly different among different antithrombotic methods. Single antiplatelet therapy was associated with the highest rate of adverse events, followed by dual antiplatelet therapy (DAPT). Vitamin K antagonists (VKAs) and new oral anticoagulants (NOACs) carried lower rates of adverse events. Conclusions Anticoagulant therapy had better safety and efficacy than antiplatelet therapy. Thus, for patients with nonabsolute anticoagulant contraindications, anticoagulant therapy rather than DAPT should be actively selected. NOACs displayed potential for further development, and these treatments might represent alternatives to VKAs in the future.
Effect of nicorandil treatment adjunctive to percutaneous coronary intervention in patients with acute myocardial infarction: a systematic review and meta-analysis
Authors: Zhou Jin , Xu Jing , Cheng Aijuan , Li Peng , Chen Bingwei , Sun Shan 
Published: November 2020

Objective There is controversy whether nicorandil treatment has cardioprotective effects in patients with acute myocardial infarction (AMI) following percutaneous coronary intervention (PCI). This meta-analysis was conducted to assess the efficacy of nicorandil on functional and clinical outcomes after PCI. Methods Systematic databases were searched to retrieve studies that compared the effect of nicorandil with a control group in patients with AMI who underwent PCI. Outcomes related to coronary blood flow, and functional and clinical outcomes were extracted and a meta-analysis was performed. Trial sequential analysis was conducted to estimate the required sample size for statistical power. Results Twenty-four trials involving 2965 patients with AMI were enrolled. Pooled results showed that nicorandil treatment significantly suppressed the incidence of no-reflow phenomenon and reperfusion arrhythmia after reperfusion, improved the left ventricular ejection fraction and left ventricular end-systolic volume index, and reduced major adverse cardiovascular events and cardiovascular death. Trial sequential analysis confirmed the effect of nicorandil in reducing the incidence of no-reflow phenomenon and follow-up major adverse cardiovascular events in patients with AMI after PCI. Conclusion Our findings suggest that nicorandil treatment adjunctive to reperfusion therapy improves myocardial reperfusion, cardiac function, and clinical outcomes in patients with AMI.
The microRNA-152/human leukocyte antigen-G axis affects proliferation and immune escape of non-small cell lung cancer cells
Authors: Fu Jun , Mao Jun , Wang Chun 
Published: November 2020

Objective To investigate the role of human leukocyte antigen (HLA-G) on proliferation, invasion, and immune escape in non-small cell lung cancer (NSCLC). Methods The relationship between HLA-G and overall survival (OS) of NSCLC patients was analyzed using the KMPlot database. The expression of micro (mi)R-152 or HLA-G was modulated by transfecting synthetic oligonucleotides, and the impact of the miR-152/HLA-G axis on proliferation, invasion, colony formation in soft agar, and tolerance to natural killer (NK) cell cytolysis was measured. Results Bioinformatics analysis showed that high HLA-G expression was correlated with poor OS in NSCLC patients. The tolerance of NSCLC cells to NK cytotoxicity was negatively correlated with HLA-G and positively correlated with miR-152 expression. Over-expressing miR-152 inhibited HLA-G expression in A549 cells and attenuated cell proliferation, migration, colony formation ability, and tolerance to NK cells. However, blocking HLA-G expression by small interfering RNA did not affect migration or colony formation, but only proliferation and tolerance to NK cells in vitro and in vivo. Blocking Ig-like transcript 2 on the surface of NK cells increased their killing effect in the presence of high HLA-G expression. Conclusions miR-152/HLA-G axis plays an oncogenic role in NSCLC by affecting cell proliferation and immune escape.
Thônis-Héracléion : Mémoire et Reflets de L’Histoire Saïte
Authors: Goddio Franck , von Bomhard Anne-Sophie , Grataloup Catherine 
Published: November 2020

Thonis-Heracleion and Saïs, located close to each other geographically, have shared a common history over several centuries. Numerous bronze objects dating from the Twenty-Sixth Dynasty were brought to light in the northernmost waterway leading from the Canopic mouth east to west across Thonis-Heracleion. Among these artefacts are four bronze plaques engraved with the names of kings, one displaying an unknown Horus name in the frame of a serekh. Attempts to identify this king led to the establishment of a list of the rulers to whom this name might be attributed in view of the historical data and the archaeological results obtained on site. Thônis-Héracléion et Saïs, proches l’une de l’autre d’un point de vue géographique, ont eu, pendant quelques siècles, une histoire commune. Plusieurs objets de bronze datant de la vingt-sixième dynastie ont été mis au jour le long de la voie d’eau transversale la plus septentrionale de Thônis-Héracléion qui menait d’est en ouest vers la ville à partir de l’embouchure Canopique. Parmi les artefacts, quatre sont des plaques de bronze gravées de noms royaux, et l’une d’elles donne, dans le cadre d’un serekh, un nom d’Horus inconnu. Les tentatives d’identification de ce roi amènent à dresser la liste des souverains auxquels ce nom pourrait être attribué, compte tenu des données historiques et des résultats archéologiques obtenus sur le site.
Chronic Pseudoparalysis Needs to Be Distinguished From Pseudoparesis: A Structural and Biomechanical Analysis
Authors: Ernstbrunner Lukas , El Nashar Rany , Favre Philippe , Bouaicha Samy , Wieser Karl , Gerber Christian 
Published: November 2020

Background: Chronic pseudoparalysis is generally defined as the inability to actively elevate the arm above 90° with free passive range of motion and no neurological deficits. It has been suggested that this arbitrary cutoff needs to be refined. Purpose: To analyze whether there are structural and biomechanical differences in patients with chronic pseudoparalysis and those with chronic pseudoparesis. Study Design: Case-control study; Level of evidence, 3. Methods: In this retrospective study, 50 patients with chronic massive rotator cuff tears (mRCTs; ≥2 tendons) and free passive and active scapular plane abduction <90° were divided into 2 groups: pseudoparalysis group (n = 24; active scapular plane abduction, <45°) and pseudoparesis group (n = 26; active scapular plane abduction, >45° and <90°). Radiographic measurements included the critical shoulder angle, acromiohumeral distance, posterior acromial tilt, anterior and posterior acromial coverages, and posterior acromial height on outlet views. Measurements on magnetic resonance imaging (MRI) included fatty infiltration of the rotator cuff muscles, anterior (subscapularis) and posterior (infraspinatus/teres minor) tear extensions, and global (anterior + posterior) tear extension in the parasagittal plane. A published musculoskeletal model was used to simulate the effect of different mRCTs on the muscle force required for scapular plane abduction. Results: Plain radiographs revealed no differences between patients with chronic pseudoparalysis and those with pseudoparesis. MRI assessment showed significant differences between patients with chronic pseudoparalysis and those with pseudoparesis with respect to fatty infiltration of the subscapularis (2.9 vs 1.6; P < .001) and infraspinatus (3.6 vs 3.0; P < .001) muscles, and anterior (−23° vs 4°; P < .001), posterior (−23° vs −14°; P = .034), and global rotator cuff (225° vs 190°; P < .001) tear extensions. The anterior tear extension in patients with chronic pseudoparalysis always involved more than 50% of the subscapularis, which was associated with an odds ratio of 5 for inability to actively abduct more than 45°. The biomechanical model was unable to find a combination of muscles that could balance the arm in space when the tear extended beyond the supraspinatus and the cranial subscapularis. Conclusion: This study confirms that chronic pseudoparalysis and pseudoparesis are associated with different structural lesions. In the setting of a chronic mRCT, involvement of more than 50% of the subscapularis tendon with fatty infiltration of stage 3 is associated with pseudoparalysis of active scapular plane abduction <45°. The key function of the subscapularis was confirmed in the biomechanical model.
Applying SLICC and ACR/EULAR systemic lupus erythematosus classification criteria in a cohort of patients with undifferentiated connective tissue disease
Authors: Drehmel Kyle R , Erickson Alan R , England Bryant R , Michaud Kaleb D , Sayles Harlan R , Hearth-Holmes Michelene P 
Published: November 2020

Background/objective New classification criteria for SLE have recently been developed. How these criteria affect the classification of patients with the SLE-mimicking condition UCTD is poorly understood. This study investigated the reclassification of UCTD patients using newly derived SLE criteria. Methods Patients with UCTD were identified within a single academic medical center using ICD9/10 codes. Medical record review was performed to confirm UCTD diagnosis and identify disease features present at diagnosis. The SLICC and ACR/EULAR criteria were applied, after which we compared the proportion of patients reclassified as SLE and determined which disease features were associated with reclassification. Results A total of 129 patients were included in the study. When applying the SLICC and ACR/EULAR criteria, 18 (14.0%) and 26 patients (20.2%) were reclassified as SLE. Comparison with McNemar’s test trended toward statistical significance (p = 0.057). Cohen’s kappa coefficient was 0.62 (p < 0.001), indicating substantial agreement between these criteria. Disease features associated with reclassification as SLE were renal involvement, leukopenia, thrombocytopenia, anti- dsDNA antibody, hypocomplementemia, non-scarring alopecia (SLICC), and arthritis (ACR/EULAR). Conclusions Both the SLICC and ACR/EULAR criteria exhibit increased SLE classification. These newer classification criteria could be used to increase the number of SLE patients in future clinical studies.
Parents’ Experiences of Having a Young Child With Acute Lymphoblastic Leukemia in China
Authors: Liu Qian , Petrini Marcia A. , Luo Dan , Yang Bing Xiang , Yang Jiong , Haase Joan E. 
Published: November 2020

Background: Understanding parents’ experiences is a prerequisite to developing interventions that are sensitive to needs of children and families. In China, little is known about parental experiences of having a young child with acute lymphoblastic leukemia (ALL). This phenomenological study aimed to describe parental experiences of having a young child with ALL in China. Method: Ten parents, recruited in central China using purposive sampling, participated in face-to-face, in-depth interviews using Haase’s adaptation of Colaizzi’s phenomenological method. Results: Five theme categories were identified: (a) The Cancer Diagnosis as a Terrible Disaster—The Sky is Falling, (b) Fighting the Beast, (c) Putting on a Happy Face and Other Coping Strategies, (d) Diagnosis Disclosure: If We Tell and How to Tell, and (e) Hope-Filled Expectations: Returning to Normal Life. Conclusion: Parents put their child’s health as their top priority. They strive to manage uncertainty about prognosis and cope with enormous pressures caused by children’s suffering, financial burden, and stigma. Parents also express their resilience and hope throughout their child’s cancer journey. Support services to strengthen specific families’ protective factors (i.e., family/community support, hope, and positive coping) are needed to foster resilience and quality of life. Health care professionals should systematically assess parents’ needs, provide validated education materials, and implement tailored interventions across the cancer continuum. Public education and advocacy about cancer is also necessary to decrease cancer-related stigma, and provide financial aid and health care resources in pediatric oncology.
MRI of the optic nerve sheath and globe in cats with and without presumed intracranial hypertension
Authors: Lodzinska Joanna , Munro Elizabeth , Shaw Darren J , Suñol Anna 
Published: November 2020

Objectives The study aimed to: (1) test MRI repeatability of measurements of optic nerve sheath diameter (ONSD), optic nerve diameter (OND) and eye globe transverse diameter (ETD); (2) investigate the associations between the OND, ONSD and ETD; (3) assess whether these measurements are affected by age or body weight; and (4) test the association between ONSD, OND, ETD and ONSD:ETD ratio with presumed intracranial pressure (ICP) status. Methods This was a retrospective and blinded study where patients were allocated to presumed normal or intracranial hypertension groups based on MRI findings. The ONSD and ETD were measured and recorded. Interclass correlation coefficient (ICC) was calculated to investigate interobserver agreement. Data were analysed using the Pearson correlation coefficient, two-sample t-test and general linear model ANOVA. Results Seventy-seven cats were included, 62 with presumed normal ICP and 15 with presumed intracranial hypertension. The ICC showed moderate-to-good reliability for all measurements. Positive correlations were identified for: (1) ETD and weight; (2) ONSD and age; (3) OND and age; (4) ONSD and ETD; (5) ONSD:ETD ratio and presumed ICP status; and (6) ONSD and presumed ICP status. No difference was detected between the presumed normal and intracranial hypertension groups and ONSD, as well as ONSD:ETD ratio and presumed ICP status when patient age was considered. Conclusions and relevance The measurement of the ONSD and the ONSD:ETD ratio on T2-weighted MRI might not be reliable as non-invasive tests for diagnosing intracranial hypertension in cats.