bluuebunny/crossref_metadata_2025_split huggingface dataset:
Achieved Targeted Heart Rate Following Ivabradine Therapy Correlates With Left Ventricular Reverse Remodeling In Non-Ischemic Dilated Cardiomyopathy
Authors: Lee Jooyeon , Oh Jaewon , Ha Jaehyung , Lee Chan Joo , Kang Seok-Min 
Published: December 2024

Abstract

The effect of ivabradine on left ventricular reverse remodeling (LVRR) in heart failure with reduced ejection fraction (HFrEF) and its correlation with achieved heart rate (HR) by ivabradine in non-ischemic dilated cardiomyopathy (NIDCM) remain uncertain. A retrospective analysis of 255 sinus rhythm NIDCM patients at a tertiary center (2012 ~ 2021) were categorized into four groups based on the ivabradine use (Iva+/-) and achieved HR at 1-year (HR+/-). The HR cut-off of 70bpm was determined via receiver operating characteristic curve analysis for LVRR, defined as an absolute ≥ 10% improvement in LV ejection fraction (LVEF) from baseline, with a final LVEF ≥ 40%. LVRR incidence at 1-year was, 46.8% in Iva-/HR70+, 46.6% in Iva-/HR70-, 62.9% Iva+/HR70 + and 71.1% in Iva+/HR70-. Ivabradine treated patients with HR < 70bpm had higher incidence of LVRR than those without ivabradine (Iva+/HR70- vs. Iva-/HR70+, OR 4.85, 95%CI 1.97–11.96 P = 0.001; Iva+/HR70- vs. Iva-/HR70-, OR 3.60, 95% CI 1.41–9.18, P = 0.007) after adjustment for known predictors in a multivariate model. Consistent adherence to beta-blockers and ivabradine, along with guideline-directed medical therapy (GDMT) for HF, and sex were identified as independent predictors of LVRR. Ivabradine therapy achieving HR < 70bpm correlated with increased LVRR incidence in NIDCM patients, underscoring the role of ivabradine in HR reduction adjunctive to GDMT.
Seismic response and whipping effect of a three-dimensional isolation ancient brick pagoda
Authors: Ling Kangjie , Liu Dewen , Zhou Jiayu , Zhang Yandie , He Junkang , Li Jianhua 
Published: December 2024

Abstract

Ancient brick pagodas reflect cultural exchanges, religious beliefs, historical changes and social-cultural influences. However, as a masonry building, it is composed of a typical brittle material exhibiting pronounced anisotropic properties. The material's tensile strength is significantly inferior to its compressive strength, which may result in substantial damage to the pagoda structure during seismic events. Simultaneously, the abrupt alteration in rigidity at the top of the ancient brick pagoda has resulted in a pronounced whipping effect, significantly endangering the integrity of the structure. Due to their inadequate anti-seismic protection, modern isolation technology is employed to safeguard ancient brick pagodas. The finite-element software ABAQUS is utilized to model ancient brick pagodas and perform time-history analysis. The results indicate that both horizontal and three-dimensional isolation technologies exhibit effective earthquake mitigation under the action of earthquakes. Horizontal isolation significantly reduces horizontal shear force, acceleration, and structural damage. Meanwhile, three-dimensional isolation further alleviates vertical axial force and vertical acceleration, thereby strengthening the structure's robustness. Additionally, both isolation techniques effectively mitigate the whipping effect of the pagoda spire. To sum up, isolation technology, especially three-dimensional isolation technology, can greatly improve the seismic performance of ancient brick pagodas and reduce the risk of damage and collapse during earthquakes. These studies provide a scientific basis for the anti-seismic retrofit of ancient brick pagodas and are of great significance for the protection of this type of cultural heritage.
Ultrasonographic quantification of cardiac attributes in apparently healthy Sipli sheep: Predictive value of serum sodium and potassium
Authors: Lashari Mushtaq , Ahmad Maqsood , Awais Muhammad , Qayyum Sumama , Fatima Iram , Riaz Umair , Idris Musadiq , Farooq Umer , Rashid Haroon , Khan Musarrat Abbas , Mahmood Aisha , Afzal Muhammad Abrar , Shahzad Khawar Ali , Farah Mohammad Abul 
Published: December 2024

Abstract

Background
The morbidity and mortality in cardiac pathologies for sheep are negligible yet it has been seen that many sheep slaughtered for meat have enlarged hearts with underlying cardiac abnormalities. Furthermore, routine cardiac assessments in sheep are not carried out. The present study was conducted with an objective to ascertain reference intervals (RIs) for various cardiac attributes (volume-related and rate-related) of sheep attained through ultrasonography and to deduce their predictability through serum Na+ and K+.
Results
Regarding gender groups, it was revealed that Left Ventricular Internal Diameter systolic (LVIDs), End Systolic Volume (ESV), Left Ventricular Internal Diameter diastolic (LVIDd), End Diastolic Volume (EDV), Stroke Volume (SV), Left Ventricular Ejection Time (LVET), Ejection Fraction (EF) and Heart Rate (HR) were significantly (P ≤ 0.05) higher in females than for the males. Regarding the predictor-predictand relation, Na+ showed significant effects on several cardiac measures such as LVIDs (F = 4.879, P ≤ 0.030), ESV (F = 5.250, P ≤ .025), LVIDd (F = 5.097, P ≤ 0.027), EDV (F = 4.066, P ≤ 0.047), Cardiac Output (F = 7.834, P ≤ 0.006) and HR (F = 4.611, P ≤ 0.035).
Conclusions
It is concluded that gender, age, and electrolyte levels (Na⁺ and K⁺) significantly influence cardiac structure and function in sheep, with females and younger animals showing unique cardiac efficiency markers. Furthermore, serum Na⁺ is a reliable predictor of cardiac health in sheep. The baseline results could be used in sheep being reared in resource-poor settings where cardiac assessments are not made on a routine basis.
Towards net zero land biotechnology – a potential assessment for selected bioprocesses in Germany
Authors: Tüllinghoff Adrian , Sträuber Heike , Baleeiro Flavio César Freire , Aurich Andreas , Morejón Micjel Chávez , Meisel Kathleen , Cyffka Karl-Friedrich , Harnisch Falk , Bühler Katja , Thrän Daniela 
Published: December 2024

Abstract

To stay within the planetary boundaries circularizing economy by utilizing residues is key. Bioprocesses can leverage abundant, but recalcitrant biogenic residues, giving access to various value-added products. Accelerating circularization requires assessing the feasibility of heterogeneous biogenic residues for different, yet specific bioprocesses. Exemplifying the national level in Germany, we categorized biogenic residues compiled in the DE Biomass Monitor regarding biochemical composition and feedstock potential in a resource matrix, detailing their fractions and the quality of available data. Three biotechnological processes, making use of lignin, non-fibrous carbohydrates, and oil, respectively, served as model processes to assess the biogenic production potential. By developing material flows based on state-of-the-art conversion routes, we found that residue-based production via all three biotechnology examples can meet national demands of specific polymer precursors, medium chain carboxylates, and platform chemicals respectively, when mobilizing only 20-30% of possible raw materials. The accruing side streams underline the importance of cluster approaches early in bioprocess development. Specific challenges to fully exploiting the potential of biogenic residues were identified, including legal and acceptance issues, the need for intelligent biomass decomposition in networked production, and residue availability and management. This study provides a framework for integrating biogenic residues with biotechnological production, using the resource matrix and an initial material-to-product estimation to advance a circular economy.
Steering the Digital Shift: The Role of Fintech in Transforming Banking in Emerging Markets
Authors: Kouam Arthur William Fodouop 
Published: December 2024

Abstract

This study investigates the factors influencing fintech adoption and its impact on financial inclusion in emerging markets. The research integrates insights from the Technology Acceptance Model and the Diffusion of Innovations Theory to provide a comprehensive framework for understanding fintech adoption. Through quantitative methodologies, regulatory frameworks, sociocultural factors, and technological innovations are identified as key drivers of fintech adoption. Findings reveal a positive correlation between fintech adoption and financial inclusion, with increased access to financial services and enhanced financial literacy observed among consumers. The study underscores the importance of policymakers creating supportive regulatory environments, financial institutions investing in digital transformation, and entrepreneurs leveraging fintech innovations to drive inclusive economic growth. While limitations exist, future research avenues include exploring regional nuances in fintech adoption and addressing potential risks and challenges. This study advances knowledge of fintech's transformative potential in enhancing financial inclusion in emerging markets.
Discovery Of Significant Data Patterns In Microarray Data Based On Atomic Statistical Measures For Cancer Classification
Authors: C.Kanimozhi  , A.Valarmathi  
Published: December 2024

Abstract

Background The recent advances in DNA microarray technology helps in the early diagnosis or prognosis of cancer that provide insight for drug discovery. However, the presence of large number of irrelevant features(genes) in microarray data poses a serious challenge in building a precise classification or prediction model. The traditional filter approaches for selection of relevant genes, ignores the exploration of the intrinsic properties of the data and hence they failed to discover the data patterns that may yield the relevant genes in the dataset.Results This study proposes a novel feature selection approach to eliminate the irrelevant features and select the most relevant features in microarray data. The proposed approach is comprised of two stages: data pattern identification and subset generation. In the first stage, the potential data patterns in the microarray data are identified by exploring the statistical measures of the microarray data. As microarray data is continuous in nature, the range of target classes is chosen as selection criterion to identify a data pattern in a gene. Each gene is identified under a data pattern based on the range and position of the target classes in a linear scale. The data patterns are further categorized as Significant and Insignificant patterns depending on the ability to express themselves in the different target class. The genes that can express themselves as distinct range of values for different target classes are categorized as Significant patterns. In the second stage, traditional feature selection algorithms such as Information Gain(IG), Mutual Information(MI), Pearson and Relief are employed in the Significant patterns to select the top ranked genes as the feature subset.Conclusion The proposed approach is evaluated using six microarray datasets and the feature subsets are evaluated using standard classifiers such as Naïve Bayes(NB), Support Vector Machine(SVM) and k-Nearest Neighbors(k-NN) to assess the classification performance. The experimental results show that the proposed approach selects highly relevant genes and that the accuracy of the classifiers proves the optimality of the subset selected by the proposed approach.
Sanggenol L Alleviates Rotenone-induced Parkinson's Disease and Inhibits Mitochondrial Complex I by Apoptosis Via P13K/AKT/mTOR Signalling
Authors: Zhao Nan , Wu Menghai , Velu Periyannan , Annamalai Vijayalakshmi , Zhang Jianbin 
Published: December 2024

Background:
Parkinson’s disease (PD) is the age-associated, second most advanced
neurodegenerative illness. Rotenone is an extensively used pesticide to study PD pathology and
inhibits mitochondrial complex I. Reports indicate that rotenone exerts neurotoxicity by its capability
to produce reactive oxygen species (ROS), which eventually leads to neuronal apoptosis.

Objective:
Sanggenol L (SL) is an eminent flavonoid present in the Morus alba root bark, which
exhibits neuroprotective, anticancer, and antioxidant properties. Materials and Methods: Hence,
we assessed the neuroprotective activity of SL (5 and 10 μM/ml) on rotenone-stimulated SK-NSH
neuroblastoma cells and elucidated the effect of the P13K/AKT/mTOR signalling.

Results:
The anti-PD action of SL on proliferation, oxidative stress (OS), intracellular ROS,
apoptosis, Bax, cleaved Caspase-12, -9, -3, and Cyt-c, Bcl-2 and P13K/AKT/mTOR signaling
was determined by MTT assay, biochemical analysis, DCFDA, AO/EB staining and western
blot. It was found that SL (5 and 10 μM/ml) reduced rotenone-triggered OS, ROS levels, and
apoptosis in a concentration-related way. SL alleviates Bax, cleaved caspase-12, -9, -3, and Cytc,
while reducing Bcl-2. Furthermore, SL safer mitochondria by increase MMP and suppresses
phosphorylation of P13k/AKT/mTOR pathway, thereby regulating apoptotic signalling.

Conclusion:
Our findings indicate that SL showed protective effects against rotenone-induced
OS, mitochondrial complex-I in neuronal cell damage, which suggests that SL might potentially
serve as an anti-PD remedial candidate for PD treatment.
A Retrospective Study of Ultrasound-guided Hydrodilatation of Glenohumeral Joint Combined with Corticosteroid Injection in Patients with Frozen Shoulder
Authors: Zeng Zeng , Zhu Jiang 
Published: December 2024

Objective:
The purpose of this study was to establish the efficacy of ultrasound (US)-guided hydrodilatation of the glenohumeral joint, in conjunction with
corticosteroid injection, in alleviating pain and improving shoulder joint adhesion among patients with primary frozen shoulder (FS).

Background:
FS, also known as adhesive capsulitis, is a pathological condition characterized by pain and potential functional impairment. The natural
progression of FS involves three distinct stages: freezing, frozen, and thawing. Chronic pain in FS patients can lead to aseptic inflammation,
thickening of fibroblasts, and an abundance of type I and III collagen fibers in the vicinity of the glenohumeral joint, ligaments, and tendons. This
condition significantly impacts patients' quality of life.

Methods:
A total of 200 FS patients were enrolled in this study. All participants underwent US-guided hydrodilatation of the glenohumeral joint, combined
with corticosteroid injection, at our department. Pre- and post-treatment (1 year) ultrasound measurements were recorded for the thickness of the
axillary recess capsule (ARC), coracohumeral ligament (CHL), and subacromial bursa. Additionally, the numerical rating scale (NRS) and
Constant-Murley score (CMS) were assessed to evaluate pain intensity and shoulder function, respectively.

Results:
Prior to the commencement of treatment, the measurements indicated a thickness of 4.8±2.3 mm for the ARC, 4.2±1.7 mm for the CHL, and
3.9±1.4 mm for the subacromial bursa. Additionally, the preoperative assessment using the NRS scale for pain yielded a score of 6.4±2.0, while the
CMS score for the joint function was 35.8±8.5. Following one year of treatment, a notable decrease was observed in the thickness of ARC, CHL,
and subacromial bursa. Furthermore, significant improvements were recorded in both the pain NRS score and the CMS score

Conclusion:
US-guided hydrodilatation of the glenohumeral joint, in combination with corticosteroid injection, may help improve the symptom and function of
FS.
Discovery of a Novel Co-crystal of Chrysin and Oroxylin a with Anticancer Properties from Leaves of Oroxylum indicum
Authors: Singh Salam Asbin , Singh Asem Robinson , Singh Atom Rajiv , Devi Anoubam Sujita , Korimayum Minhaz , Singh Lisam Shanjukumar 
Published: December 2024

Background:
As the number of new cancer cases increases every year, there is a necessity to develop
new drugs for the treatment of different types of cancers. Plants' resources are considered to be huge reservoirs
for therapeutic agents in nature. Among all the medicinal plants, Oroxylum indicum is one of the most widely
used medicinal plants in India, China, and Southeast Asian countries. Combinatorial drug treatment, on the other
hand, is favored over single drug treatment in order to target multiple biomolecular moieties that help in the
growth and development of cancer. Therefore, combinatorial drug treatment using a co-crystal of multiple drugs
gives researchers an idea of the development of a new type of drug for targeting multiple targets. In this study, a
new co-crystal of chrysin and oroxylin A was isolated from the leaves of O. indicum, and its anticancer properties
were studied in cervical cancer cells HeLa.

Aim:
This study was conducted with the aim of identifying new anticancer compounds from the leaves of Oroxylum
indicum and studying the anticancer properties of the isolated compound.

Objective:
In this study, we elucidated the structure of a new co-crystal compound, which was isolated from the
leaf extract of Oroxylum indicum. The apoptosis induction mechanism of the newly discovered co-crystal in
HeLa cells was also studied.

Methods:
A crystal compound from the chloroform extract of leaves of Oroxylum Indicum was isolated by solvent
fractionation and chromatographic methods involving HPLC. The molecular structure of the isolated crystal
was elucidated by Single Crystal-XRD, FT-IR analysis, and further determined by LC-MS. The antiproliferative
activity was carried out using an MTT assay and fluorescence microscopy, and the mechanism of apoptosis was
determined using Western blotting techniques.

Results:
The novel co-crystal consists of two active pharmaceutical ingredients (APIs) in a 1:1 ratio, i.e., oroxylin
A and chrysin. The isolated new co-crystal induced death in HeLa cells with a very low IC50 value of 8.49μM. It
induced caspase-dependent apoptosis in HeLa cells by activation of Caspase-3 through inhibition of ERKs and
activation of p38 of MAPK cell signalling pathway.

Conclusion:
This study presents the first report on the discovery of a naturally occurring co-crystal of chrysin and
oroxylin A and the involvement of ERKs and p38 of MAPK pathways in the induction of apoptosis in HeLa cells
by the co-crystal. Our study sheds light on the development of a co-crystal of chrysin and oroxylin A in a specific
ratio of 1:1 for combination therapy of the two APIs. The purified co-crystal was found to be more efficient compared
to the compounds present individually. Further analysis of the physiochemical properties and molecular
mechanisms of the isolated co-crystal in different cancer cells is warranted for its application in therapeutics.
Study of aerodynamic parameters of air distributors during interaction of round non-coaxial jets
Authors: Zaitsev O. N. , Semicheva N. E. , Burtsev A. P. , Zaitseva E. O. 
Published: December 2024

Purpose of reseach. The aim of the work is to determine the parameters of the resulting flow in the interaction of counter-misaligned air flows to ensure an intensive decrease in air velocity in production and technological premises of small volume. To achieve this goal, it is necessary to solve such tasks as analyzing existing theoretical provisions and methods for calculating air distribution systems for small production and technological premises; development of a mathematical model of the process of interaction of oncoming incompatible flows and to determine the parameters of the resulting air flow depending on the geometric characteristics of the device. The object of the study is the supply ventilation systems in industrial and technological premises of small volume with insignificant thermal loads. The subject of the study is the processes of formation of the resulting air flow created by the interaction of countermisaligned air flows.Methods. Methods of mathematical modeling of air flow motion based on the equations of aerodynamics.Results. The aerodynamic characteristics of the resulting jet are obtained – the Boussinesq coefficient and the velocity field coefficient.Conclusion. In the ambiguities, between two-meter-long-range extravehicular jets and two-meter-long-range converging streams in the inner regions, a spatial vortex zone is formed with a maximum extravehicular gradient velocity. At the boundary of the jet stream there is an intense interaction with the surrounding air, the vector of the propeller is directed by the opposite direction, and the quantity of the speed of the plane depends on the speed of the jet, which changes the nature of the swirling movements. The results show that the actual level of overshoot during a load surge is determined in the first approximation by the increment value multiplied by the difference in the values of thermal conductivity, winding-oil at the initial and final temperatures of the oils in the channels of the cooled windings, and this difference itself depends on the magnitude of the incremental damage. Optimal factor intervals for the values of the maximum value of the functions are obtained: t – from 40 to 120; ρ – from 800 to 900; c – from 1.4 to 2.3.
Improvement of mathematical methods for ensuring security based on real-time video sequence analysis
Authors: Abramov M. V, , Averchenkov A. V. 
Published: December 2024

Purpose of research. Currently, mathematical methods of video sequence analysis represent a structured set of approaches to image recognition based on the difference in the glow of different image areas. Many of these values are described using mathematical dependencies, however, existing approaches work only for standard images obtained during video data processing. The purpose of this study is to develop a new approach to analyzing images obtained, including those using terahertz radiation, which has specific characteristics, both physical and mathematical.Methods. The following theoretical and empirical scientific methods were used in this study. Analysis (the analysis of the currently known mathematical methods of image processing in order to recognize images is carried out). Synthesis (a fundamentally new approach to security systems is proposed, which is a single system consisting of separate interconnected subsystems). Modeling (an information model of a security system based on ACS has been developed using a system for analyzing and recognizing potentially dangerous objects based on a real-time video stream).Mathematization (the image analysis system is described in the language of mathematical laws and formulas).Results. As a result of the research based on the analysis of modern materials, the concept of a security system based on real-time video sequence analysis with the use of advanced object scanning technologies is proposed in the future. As the main innovation, an improved Viola-Jones image analysis method is proposed using an additional set characterizing the feature space of objects in the terahertz radiation range.Conclusion. The use of high-frequency scanning technologies with intelligent object image recognition systems in real time will significantly reduce the risks of intruders entering protected facilities, as well as increase the safety of citizens with relatively low costs for the development and implementation of upgraded security systems.