bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complex context relationships between DNA methylation and accessibility, histone marks, and hTERT gene expression in acute promyelocytic leukemia cells: perspectives for all‐trans retinoic acid in cancer therapy
Authors: Garsuault Delphine , Bouyer Claire , Nguyen Eric , Kandhari Rohan , Prochazkova‐Carlotti Martina , Chevret Edith , Forgez Patricia , Ségal‐Bendirdjian Evelyne 
Published: April 2020

Telomerase (hTERT) reactivation and sustained expression is a key event in the process of cellular transformation. Therefore, the identification of the mechanisms regulating hTERT expression is of great interest for the development of new anticancer therapies. Although the epigenetic state of hTERT gene promoter is important, we still lack a clear understanding of the mechanisms by which epigenetic changes affect hTERT expression. Retinoids are well‐known inducers of granulocytic maturation in acute promyelocytic leukemia (APL). We have previously shown that retinoids repressed hTERT expression in the absence of maturation leading to growth arrest and cell death. Exploring the mechanisms of this repression, we showed that transcription factor binding was dependent on the epigenetic status of hTERT promoter. In the present study, we used APL cells lines and publicly available datasets from APL patients to further investigate the integrated epigenetic events that promote hTERT promoter transition from its silent to its active state, and inversely. We showed, in APL patients, that the methylation of the distal domain of hTERT core promoter was altered and correlated with the outcome of the disease. Further studies combining complementary approaches carried out on APL cell lines highlighted the significance of a domain outside the minimal promoter, localized around 5 kb upstream from the transcription start site, in activating hTERT. This domain is characterized by DNA hypomethylation and H3K4Me3 deposition. Our findings suggest a cooperative interplay between hTERT promoter methylation, chromatin accessibility, and histone modifications that force the revisiting of previously proposed concepts regarding hTERT epigenetic regulation. They represent, therefore, a major advance in predicting sensitivity to retinoid‐induced hTERT repression and, more generally, in the potential development of therapies targeting hTERT expression in cancers.
Replacement model of phase change building materials for heat load calculation
Authors: Serikawa Mao , Satoh Makoto , Mae Masayuki 
Published: April 2020

AbstractPhase change materials (PCMs) may contribute to room temperature stability and heat load reduction. This research proposes a method to calculate heat load using a PCM replacement model for a thermal storage wall. Regarding the replacement of PCM with internal thermal mathematical models, the replaced PCM temperature and room temperature are related. The method to replace PCM in adjoining rooms is based on the heat transfer coefficient, heat transmission coefficient, solar absorptance on the surface of a wall, ceiling, or floor, etc. We compare the results of the proposed replacement model of room temperature and heat load to a detailed heat load calculation.
Retrospective quality metrics review of stereotactic radiosurgery plans treating multiple targets using single‐isocenter volumetric modulated arc therapy
Authors: Cui Yunfeng , Gao Hao , Zhang Jiahan , Kirkpatrick John P. , Yin Fang‐Fang 
Published: April 2020

AbstractPurposeTo characterize key plan quality metrics in multi‐target stereotactic radiosurgery (SRS) plans treated using single‐isocenter volumetric modulated arc therapy (VMAT) in comparison to dynamic conformal arc (DCA) plans treating single target. To investigate the feasibility of quality improvement in VMAT planning based on previous planning knowledge.Materials and methods97 VMAT plans of multi‐target and 156 DCA plans of single‐target treated in 2017 at a single institution were reviewed. A total of 605 targets were treated with these SRS plans. The prescription dose was normalized to 20 Gy in all plans for this analysis. Two plan quality metrics, target conformity index (CI) and normal tissue volume receiving more than 12 Gy (V12Gy), were calculated for each target. The distribution of V12Gy per target was plotted as a function of the target volume. For multi‐target VMAT plans, the number of targets being treated in the same plan and the distance between targets were calculated to evaluate their impact on V12Gy. VMAT plans that had a large deviation of V12Gy from the average level were re‐optimized to determine the possibility of reducing the variation of V12Gy in VMAT planning.ResultsConformity index of multi‐target VMAT plans were lower than that of DCA plans while the mean values of 12 Gy were comparable. The V12Gy for a target in VMAT plan did not show apparent dependence on the total number of targets or the distance between targets. The distribution of V12Gy exhibited a larger variation in VMAT plans compared to DCA plans. Re‐optimization of outlier plans reduced V12 Gy by 33.9% and resulted in the V12Gy distribution in VMAT plans more closely resembling that of DCA plans.ConclusionThe benchmark data on key plan quality metrics were established for single‐isocenter multi‐target SRS planning. It is feasible to use this knowledge to guide VMAT planning and reduce high V12Gy outliers.
Low‐PGM and PGM‐Free Catalysts for Proton Exchange Membrane Fuel Cells: Stability Challenges and Material Solutions
Authors: Du Lei , Prabhakaran Venkateshkumar , Xie Xiaohong , Park Sehkyu , Wang Yong , Shao Yuyan 
Published: April 2020

AbstractFuel cells as an attractive clean energy technology have recently regained popularity in academia, government, and industry. In a mainstream proton exchange membrane (PEM) fuel cell, platinum‐group‐metal (PGM)‐based catalysts account for ≈50% of the projected total cost for large‐scale production. To lower the cost, two materials‐based strategies have been pursued: 1) to decrease PGM catalyst usage (so‐called low‐PGM catalysts), and 2) to develop alternative PGM‐free catalysts. Grand stability challenges exist when PGM catalyst loading is decreased in a membrane electrode assembly (MEA)—the power generation unit of a PEM fuel cell—or when PGM‐free catalysts are integrated into an MEA. More importantly, there is a significant knowledge gap between materials innovation and device integration. For example, high‐performance electrocatalysts usually demonstrate undesired quick degradation in MEAs. This issue significantly limits the development of PEM fuel cells. Herein, recent progress in understanding the degradation of low‐PGM and PGM‐free catalysts in fuel cell MEAs and materials‐based solutions to address these issues are reviewed. The key factors that degrade the MEA performance are highlighted. Innovative, emerging material concepts and development of low‐PGM and PGM‐free catalysts are discussed.
Liquid‐Superrepellent Bioinspired Fibrillar Adhesives
Authors: Liimatainen Ville , Drotlef Dirk‐Michael , Son Donghoon , Sitti Metin 
Published: April 2020

AbstractBioinspired elastomeric fibrillar surfaces have significant potential as reversible dry adhesives, but their adhesion performance is sensitive to the presence of liquids at the contact interface. Like their models in nature, many artificial mimics can effectively repel water, but fail when low‐surface‐tension liquids are introduced at the contact interface. A bioinspired fibrillar adhesive surface that is liquid‐superrepellent even toward ultralow‐surface‐tension liquids while retaining its adhesive properties is proposed herein. This surface combines the effective adhesion principle of mushroom‐shaped fibrillar arrays with liquid repellency based on double re‐entrant fibril tip geometry. The adhesion performance of the proposed microfibril structures is retained even when low‐surface‐tension liquids are added to the contact interface. The extreme liquid repellency enables real‐world applications of fibrillar adhesives for surfaces covered with water, oil, and other liquids. Moreover, fully elastomeric liquid‐superrepellent surfaces are mechanically not brittle, highly robust against physical contact, and highly deformable and stretchable, which can increase the real‐world uses of such antiwetting surfaces.
Extra‐Axial Inflammatory Signal in Parameninges in Migraine with Visual Aura
Authors: Hadjikhani Nouchine , Albrecht Daniel S. , Mainero Caterina , Ichijo Eri , Ward Noreen , Granziera Cristina , Zürcher Nicole R. , Akeju Oluwaseun , Bonnier Guillaume , Price Julie , Hooker Jacob M. , Napadow Vitaly , Nahrendorf Matthias , Loggia Marco L. , Moskowitz Michael A. 
Published: April 2020

ObjectiveCortical spreading depression (CSD) underlies the neurobiology of migraine with aura (MWA).Animal studies reveal networks of microvessels linking brain–meninges–bone marrow. CSD activates the trigeminovascular system, evoking a meningeal inflammatory response. Accordingly, this study examines the upregulation of an inflammatory marker in extra‐axial tissues in migraine with visual aura.MethodsWe used simultaneously acquired 11C‐PBR28 positron emission tomography/magnetic resonance imaging data of 18kDa translocator protein (an inflammatory marker) in MWA patients (n = 11) who experienced headaches and visual aura in the preceding month. We measured mean tracer uptake (standardized uptake value ratio [SUVR]) in 4 regions of interest comprising the meninges plus the adjacent overlying skull bone (parameningeal tissues [PMT]). These data were compared to healthy controls and patients with pain (chronic low back pain).ResultsMWA had significantly higher mean SUVR in PMT overlying occipital cortex than both other groups, although not in the PMT overlying 3 other cortical areas. A positive correlation was also found between the number of visual auras and tracer uptake in occipital PMT.InterpretationA strong persistent extra‐axial inflammatory signal was found in meninges and calvarial bone overlying the occipital lobe in migraine with visual auras. Our findings are reminiscent of CSD‐induced meningeal inflammation and provide the first imaging evidence implicating inflammation in the pathophysiology of migraine meningeal symptoms. We suspect that this inflammatory focus results from a signal that migrates from underlying brain and if so, may implicate newly discovered bridging vessels that crosstalk between brain and skull marrow, a finding of potential relevance to migraine and other neuroinflammatory brain disorders. ANN NEUROL 2020;87:939–949
Molecular Thorium Trihydrido Clusters Stabilized by Cyclopentadienyl Ligands
Authors: Chen Runhai , Qin Guorui , Li Shihui , Edwards Alison J. , Piltz Ross O. , Del Rosal Iker , Maron Laurent , Cui Dongmei , Cheng Jianhua 
Published: April 2020

AbstractHydrogenolysis of alkyl‐substituted cyclopentadienyl (CpR) ligated thorium tribenzyl complexes [(CpR)Th(p‐CH2‐C6H4‐Me)3] (1–6) afforded the first examples of molecular thorium trihydrido complexes [(CpR)Th(μ‐H)3]n (CpR=C5H2(tBu)3 or C5H2(SiMe3)3, n=5; C5Me4SiMe3, n=6; C5Me5, n=7; C5Me4H, n=8; 7–10 and 12) and [(Cp#)12Th13H40] (Cp#=C5H4SiMe3; 13). The nuclearity of the metal hydride clusters depends on the steric profile of the cyclopentadienyl ligands. The hydrogenolysis intermediate, tetra‐nuclear octahydrido thorium dibenzylidene complex [(Cpttt)Th(μ‐H)2]4(μ‐p‐CH‐C6H4‐Me)2 (Cpttt=C5H2(tBu)3) (11) was also isolated. All of the complexes were characterized by NMR spectroscopy and single‐crystal X‐ray analysis. Hydride positions in [(CpMe4)Th(μ‐H)3]8 (CpMe4=C5Me4H) were further precisely confirmed by single‐crystal neutron diffraction. DFT calculations strengthen the experimental assignment of the hydride positions in the complexes 7 to 12.
Oberflächenladungen an der CaF2‐Wasser‐Grenzfläche erlauben eine sehr schnelle intermolekulare Übertragung von Schwingungsenergie
Authors: Lesnicki Dominika , Zhang Zhen , Bonn Mischa , Sulpizi Marialore , Backus Ellen H. G. 
Published: April 2020

AbstractWir untersuchen die Dynamik von Wasser in Kontakt mit festem Calciumfluorid, bei dem sich bei niedrigem pH‐Wert durch Fluoridauflösung lokalisierte Ladungen bilden können. Wir verwenden zweidimensionale oberflächenspezifische Schwingungsspektroskopie zur Quantifizierung der Heterogenität der Grenzflächenwassermoleküle (D2O) und zum Erhalt von Informationen über die Sub‐Pikosekunden‐Schwingungsenergierelaxationsdynamik an der Fest‐Flüssig‐Grenzfläche. Dabei beobachten wir, dass stark wasserstoffgebundene OD‐Gruppen, mit einer Schwingungsfrequenz unter 2500 cm−1, sehr schnelle spektrale Diffusion und Vibrationsrelaxation zeigen. Für schwach H‐gebundene OD‐Gruppen über 2500 cm−1 verlangsamt sich die Dynamik erheblich. Atomistische Simulationen, basierend auf der elektronischen Strukturtheorie, belegen den molekularen Ursprung des Energietransports durch das lokale Wasserstoffbrückennetzwerk. Wir kommen zu dem Schluss, dass stark orientierte wasserstoffgebundene Wassermoleküle der adsorbierten Schicht, deren Orientierung durch lokalisierte Ladungsdefekte fixiert werden, Schwingungsenergie sehr schnell austauschen können. Diesem schnellen Austausch liegt ein starker kollektiver Dipol zugrunde, welches die teilweise fehlende Solvatationshülle kompensiert.
Palladium‐Catalyzed Enantioselective Heck Carbonylation with a Monodentate Phosphoramidite Ligand: Asymmetric Synthesis of (+)‐Physostigmine, (+)‐Physovenine, and (+)‐Folicanthine
Authors: Chen Ming , Wang Xucai , Yang Pengfei , Kou Xun , Ren Zhi‐Hui , Guan Zheng‐Hui 
Published: April 2020

AbstractReported herein is the development of the first enantioselective monodentate ligand assisted Pd‐catalyzed domino Heck carbonylation reaction with CO. The highly enantioselective domino Heck carbonylation of N‐aryl acrylamides and various nucleophiles, including arylboronic acids, anilines, and alcohols, in the presence of CO was achieved. A novel monodentate phosphoramidite ligand, Xida‐Phos, has been developed for this reaction and it displays excellent reactivity and enantioselectivity. The reaction employs readily available starting materials, tolerates a wide range of functional groups, and provides straightforward access to a diverse array of enantioenriched oxindoles having β‐carbonyl‐substituted all‐carbon quaternary stereocenters, thus providing a facile and complementary method for the asymmetric synthesis of bioactive hexahydropyrroloindole and its dimeric alkaloids.
Flame retardancy of water‐based intumescent coatings with etherified melamine–formaldehyde and polyvinyl acetate copolymer hybrid resin
Authors: Chuang Chih‐Shen , Wu Chieh‐Ying , Wu Kuang‐Chong , Sheen Horn‐Jiunn 
Published: April 2020

AbstractThis study investigated etherified melamine–formaldehyde (MF) and polyvinyl acetate copolymer hybrid resins with different intumescent formulations to improve the flame retardancy of plywood. The CO and CO2 emissions of intumescent coatings were also investigated. The miscibility of two resins is indicated by a single cure peak. Intumescence with a hybrid resin demonstrated better flame retardancy relative to that with a pure etherified MF resin. The results of scanning electron microscopy and a cone calorimeter test indicated that a lower binder resin (BR) content enhances fire retardancy and forms an ideal char. Furthermore, an evaluation of total heat release in addition to CO and CO2 emissions (for 300 s) revealed that the intumescent coating had the same flame retardancy when the BR content was increased by 40%. The survival duration of the chemical structures of the phosphocarbonaceous chars was verified using Fourier‐transform infrared spectroscopy and solid‐state phosphorus‐31 nuclear magnetic resonance analyses.
Two‐generation reproduction and limited teratology studies of ethanamizuril fed to rats
Authors: Zhao Juan , Wang Mi , Wang Xiaoyang , Fei Chenzhong , Xue Feiqun , Zhang Lifang , Wang Zhaoxiong , Zhang Keyu 
Published: April 2020

AbstractEthanamizuril, a new anticoccidial agent that belongs to triazine derivatives, has a broad and good anticoccidial activity. To evaluate the reproductive toxicity and teratogenic potential of ethanamizuril, different concentrations of ethanamizuril were administered to Sprague–Dawley rats by feeding diets containing 0, 2, 8, and 30 ppm, respectively. Each group consisting of 30 males and 30 females (F0) was treated with different concentrations of ethanamizuril through a 13‐week period before mating and during mating, gestation, parturition and lactation. In the 30 ppm dose group, pup body weight on days 7 and 21 in F1 offspring and day 21 in the F2a offspring were significantly decreased. A limited teratogenicity study was performed in combination with the F1 generation of a two‐generation reproduction study. F1 offspring of the reproduction study were mated after weaning of the F2a offspring. Pregnant female rats were subjected to cesarean section on gestational day 20 for teratogenic examination. No obvious body weights, fetal body lengths, tail lengths, litter weights, number of viable fetuses, external, skeletal, or visceral malformations in fetuses were noted in any groups in the teratogenic test, but ethanamizuril could be passed on to offspring through lactation.
Identification of key lncRNAs in the tumorigenesis of intraductal pancreatic mucinous neoplasm by coexpression network analysis
Authors: Ding Jun , Li Yi , Zhang Yong , Fan Bin , Li Qinghe , Zhang Jian , Zhang Jiayao 
Published: April 2020

AbstractIntraductal papillary mucinous neoplasm (IPMN) is an intraepithelial precancerous lesion of pancreatic ductal adenocarcinoma (PDAC) that progresses from adenoma to carcinoma, and long noncoding RNAs (lncRNA) might be involved in the tumorigenesis. In this study, we obtained the expression profiles of more than 4000 lncRNAs by probe reannotation of a microarray dataset. As a correlation network‐based systems biology method, weighted gene coexpression network analysis (WGCNA) was used to find clusters of highly correlated lncRNAs in the tumorigenesis of IPMN, which covered four stepwise stages from normal main pancreatic duct to invasive IPMN. In the most relevant module (R2 = −0.75 and P = 5E‐05), three hub lncRNAs were identified (HAND2‐AS1, CTD‐2033D15.2, and lncRNA‐TFG). HAND2‐AS1 and CTD‐2033D15.2 were negatively correlated with the tumorigenesis (P in one‐way ANOVA test = 1.45E‐07 and 1.39E‐0.5), while lncRNA‐TFG were positively correlated with the tumorigenesis (P = 3.99E‐08). The validation set reached consistent results (P = 2.66E‐03 in HAND2‐AS1, 1.47E‐04 in CTD‐2033D15.2 and 6.23E‐08 in lncRNA‐TFG). In functional enrichment analysis, the target genes of microRNAs targeting also these lncRNAs were overlapped in multiple biological processes, pathways and malignant diseases including pancreatic cancer. In survival analysis, patients with higher expression of HAND2‐AS1‐targeted and CTD‐2033D15.2‐targeted microRNAs showed a significantly poorer prognosis in PDAC, while high expression of lncRNA‐TFG‐targeted microRNAs demonstrated an obviously better prognosis (log‐rank P < .05). In conclusion, by coexpression network analysis of the lncRNA profiles, three key lncRNAs were identified in association with the tumorigenesis of IPMN, and those lncRNAs might act as early diagnostic biomarkers or therapeutic targets in pancreatic cancer.
Mammalian‐Like Inflammatory and Pro‐Resolving Oxylipins in Marine Algae
Authors: Jagusch Hans , Baumeister Tim U. H. , Pohnert Georg 
Published: April 2020

AbstractOxylipins constitute a family of oxidized fatty acids, that are well known as tissue hormones in mammals. They contribute to inflammation and its resolution. The major classes of these lipid mediators are inflammatory prostaglandins (PGs) and leukotrienes (LTs) as well as pro‐resolving resolvins (Rvs). Understanding their biosynthetic pathways and modes of action is important for anti‐inflammatory interventions. Besides mammals, marine algae also biosynthesize mammalian‐like oxylipins and thus offer new opportunities for oxylipin research. They provide prolific sources for these compounds and offer unique opportunities to study alternative biosynthetic pathways to the well‐known lipid mediators. Herein, we discuss recent findings on the biosynthesis of oxylipins in mammals and algae including an alternative pathway to prostaglandin E2, a novel pathway to a precursor of leukotriene B4, and the production of resolvins in algae. We evaluate the pharmacological potential of the algal metabolites with implications in health and disease.
Asymmetric Imides as Electrolyte Additive for Lithium‐Ion Batteries with NCM111 Cathode
Authors: Weigel Simon , Eisele Lea , Klose Petra , Lucht Brett , Beichel Witali , Krossing Ingo 
Published: April 2020

AbstractThe synthesis, spectroscopic and electrochemical characterization of Li[N(SiMe3)(SO2RF)] (RF=CF3, n‐C4F9) as well their behavior as electrolyte additive in lithium ion batteries (LIBs) is reported. The lithium salts were obtained by deprotonation of the corresponding acids HN(SiMe3)(SO2RF) with n‐butyllithium in n‐pentane. The electrochemical investigations suggested potential as additives for LIBs. Thus, NCM111/graphite cells (NCM111=Li[Ni0.33Co0.33Mn0.33]O2) with LP57 as electrolyte (LP57=1.0 M LiPF6 in EC/EMC 3 : 7) were built to test the performance. Cells with Li[N(SiMe3)(SO2RF)] as additives show coulombic efficiencies of over 99.6 %, less capacity fading over 55 cycles and a significantly lower cell impedance built up.
Tunable Graphene Systems for Water Desalination
Authors: Shao Changxiang , Zhao Yang , Qu Liangti 
Published: April 2020

AbstractThe desalination technologies of sea water are becoming of importance in providing sustainable fresh water. Graphene, as a fashion of two‐dimensional carbon monolayer, has emerged as a promising candidate to build up the material platform for water desalination. In this review, we summarize the development of tunable graphene systems applied in three kinds of water desalination techniques, including capacitive deionization, solar steam generation, and nanofiltration. The current achievements in this field have been highlighted with discussion of the challenges for desalination technologies.