bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFECTS AND UNDERLYING MECHANISM OF 5-LIPOXYGENASE INHIBITOR (ZILEUTON) ON MICE DEPRESSIVE-LIKE BEHAVIOR
Authors: PANIGRAHI SAPTARSHI , SURAI SOMNATH , HONG HAO 
Published: March 2020

Objective: Treatment experiment was conducted to investigate the effectiveness and mechanism of the action of zileuton in corticosteroid-induced depressive mice model through neuroinflammation.
Methods: The mice were randomly separated into four groups: (Veh+Veh), (Corticosteroid+Veh), (Corticosteroid+ZIL50), and (Corticosteroid+ZIL100). Intraperitoneal injection of corticosterone (CORT) (20 mg/kg for 6 weeks) was used in the mice to induce depression and neuroinflammation diverse from the Veh+Veh group, which was injected only physiological saline. The drug-treated groups (Corticosteroid+ZIL50 and Corticosteroid+ZIL100) were orally administered with the mentioned doses of zileuton. After confirming the effectiveness of zileuton through the behavioral tests, the mechanism of the action of the drug was explored through a set of biochemical assays.
Results: Zileuton (50/100 mg/kg) administration improved the performance of the mice in the behavioral experiments (p<0.05 or 0.01). Immunohistochemistry detection of Iba1+ revealed over activation of microglial cells in the corticosteroid-treated mice which was suppressed by the zileuton (50 or 100 mg/kg [p<0.05 or 0.01]). Through Western blotting tests, it had been found that CORT (i.p.) administration led to the increment of the protein 5-Lipoxygenase in the mouse hippocampus associated with neuroinflammation, which was decreased significantly by zileuton (p<0.05 or 0.01). Level of tumor necrosis factor-alpha, interleukin-1 beta, nuclear factor kappa B p65 protein (for neuroinflammation), Bax, and cleaved caspase-3 and TUNEL assay increased, and Bcl-2 expression decreased in the CORT-induced depressive mice. These were significantly reversed by zileuton (50 or 100 mg/kg [p<0.05 or 0.01]).
Conclusion: It can be concluded that selective 5-lipoxygenase inhibitor zileuton can efficiently inhibit the depressive-like behavior/activity in CORT-induced depressive mouse model. Moreover, the underlying mechanism may be the inhibition of hippocampal neuroinflammation and apoptosis.
El asilo y la experiencia española
Authors: Fernández Marugán Francisco 
Published: March 2020

El artículo plantea que ante la problemática de la globalización y los avances tecnológicos, la migración y el cambio climático, son los problemas más agudos de nuestro tiempo, actualmente existe un número considerable de personas desplazadas de manera forzada, como consecuencia de las guerras, las situaciones de violen¬cia generalizada, los efectos del cambio climático y las violaciones sistemáticas de los derechos humanos. Este artículo analiza la forma en la que España en su Historia ha recibido a los exiliados por migración, puntualizando los casos de Venezuela y Siria.
IMPLICAÇÕES ODONTOLÓGICAS DO ACOMETIMENTO PELA DOENÇA CELÍACA
Authors: Spezzia Sérgio 
Published: March 2020

Resumo Doença celíaca (DC) consta de desordem inflamatória crônica autoimune, que desencadeia reação autoimune na região do intestino delgado. As modificações ocasionadas pela DC na mucosa do intestino delgado possuem reversibilidade, ao passo que orienta-se os pacientes a não ingerir mais alimentação que contenha o glúten. Deve ser adotada também como medida a averiguação das bulas dos remédios, no intuito de verificar se os mesmos contém traços de glúten em sua fórmula. Existem inúmeros pacientes assintomáticos, o que dificulta a determinação diagnóstica e sabe-se que caso não se proceda ao diagnóstico e ao tratamento da DC em tempo hábil pode haver complicações indesejáveis. O objetivo do presente artigo foi averiguar acerca das manifestações bucais ocorridas em pacientes doentes em decorrência da presença da DC. As principais manifestações orais da DC que podem ocorrer envolvem hipossalivação; glossites; defeitos de esmalte; úlceras aftosas recorrentes; estomatites; aftas; manchas por insuficiência ou por excesso de cálcio, dentre outras. O conhecimento e a conscientização prévia pelos cirurgiões dentistas acerca das repercussões bucais acarretadas pela possível presença da DC em seus pacientes é de fundamental importância para o aprimoramento diagnóstico e para a adoção de condutas odontológicas apropriadas. Palavras-chave: Doença Celíaca. Dieta. Diagnóstico Precoce. Hipoplasia do Esmalte Dentário. Keywords: Celiac Disease. Diet. Early Diagnosis. Dental Enamel Hypoplasia.
PLASMA RICO EM FIBRINA (PRF) COMO OPÇÃO DE RECOBRIMENTO APÓS ROTAÇÃO DE RETALHO PALATINO PARA TRATAMENTO DE FÍSTULA BUCOSSINUSAL
Authors: Mérola Corrêa Rafael 
Published: March 2020

ResumoO desenvolvimento de uma fístula bucossinusal, a partir de uma comunicação gerada entre a cavidade oral e o seio maxilar, pode ser favorecido por um não fechamento espontâneo ou por uma sinusite maxilar crônica já instalada. O tratamento da fístula bucossinusal depende de fatores que podem beneficiar ou dificultar o prognóstico dos casos, como a localização, causa e o tamanho do defeito gerado. Diferentes técnicas são descritas na literatura para o tratamento destes defeitos orosinusais, como retalhos locais deslizantes ou rotacionados, enxertos autógenos ou o uso da bola de gordura bucal. O objetivo do presente trabalho é apresentar o caso clínico de uma fístula bucossinusal pós exodontia há aproximadamente 05 anos, não corrigida imediatamente, tratada através de retalho mucoso palatino rotacionado. Como coadjuvante para a cicatrização da área doadora foi utilizado membrana de fibrina rica em plaquetas. A técnica do retalho palatino mostrou-se uma opção favorável para o fechamento da fístula bucossinusal e o uso dos fatores de crescimento permitiu vascularização adequada na área doadora e no retalho rotacionado, o que favoreceu a hemostasia vascular e estimulou a recuperação dos tecidos moles adjacentes.Palavras-chave: Seio maxilar, fístula bucoantral, cirurgia bucal, fibrina rica em plaquetas. AbstractThe development of a bucosinusal fistula from a communication generated between the oral and maxillary cavity may be favored by a spontaneous unblocked or an existing chronic maxillary sinusitis. The treatment of bucosinusal fistula depends on factors that may benefit or hinder the prognosis of cases, such as location, cause and size of the defect used. Different techniques are described in the literature for the treatment of these oral defects, such as sliding or rotating local flaps, autogenous grafts or the use of the buccal fat ball. The aim of the present study is to present the clinical case of a post-extraction bucosinusal fistula approximately 05 years ago, not immediately corrected, treated through a rotated palatal mucosal flap. As an adjunct to the healing of the donor area, a platelet-rich fibrin membrane was used. The palatal flap technique proved to be a favorable option for the closure of the bucosinusal fistula and the use of growth factors allowed adequate vascularization in the donor area and in the rotated flap, which favored vascular hemostasis and stimulated the recovery of adjacent soft tissues.Key-words: Maxillary sinus, oroantral fistula, oral surgery, platelet-rich fibrin
Forecast Cloudy—Fair or Stormy Weather: Cloud Computing Insights and Issues
Authors: Church Kimberly Swanson , Schmidt Pamela J. , Ajayi Kemi 
Published: March 2020

ABSTRACT
To engage theory and practice of cloud computing in business, the third annual Journal of Information Systems Conference (JISC) brought together 29 academic researchers and 14 practitioners. This commentary reviews and synthesizes discussions and insights provided by three keynote presentations and panel discussions. In addition to sharing insights from the conference, this commentary identifies major themes, incorporates relevant current literature, and suggests potential research questions expressed by practitioners. The JISC emphasized the impact of the rapid maturing of cloud computing services on accounting information systems (AIS). Several recurring themes emerged throughout the conference: (1) rapid growth and evolution of cloud managed services, (2) security, privacy, and risk in the cloud ecosystem, (3) impact of cloud computing for data analytics, and (4) emerging and disruptive financial technologies and trends for the cloud. Most of the discussion surrounding these themes predominantly focused on the perspectives of cloud assurance and cloud service providers.
Teresa Basile, El desarme de Calibán: Debates culturales y diseños literarios en la posdictadura uruguaya. Pittsburgh, Universidad de Pittsburgh, 2018, Nuevo Siglo, 324 páginas
Authors: Sosa San Martín Gabriela 
Published: March 2020

Reseña del libro El desarme de Calibán: Debates culturales y diseños literarios en la posdictadura uruguaya
Juan Antonio Ennis y Laura Sesnich (eds.), Enriqueta la criolla y La hija de Giacumina: Literatura popular, lenguas mixtas y naturalismo en dos folletos del 80. La Plata-Berlín, FaHCE.UNLP-Ibero Amerikanisches Institut Preußischer Kulturbesitz, 2017, Biblioteca Orbis Tertius, 274 páginas
Authors: Ortiz Gambetta Eugenia 
Published: March 2020

Reseña del libro Enriqueta la criolla y La hija de Giacumina: Literatura popular, lenguas mixtas y naturalismo en dos folletos del 80
Stomatal traits in Iberian populations of Osmunda regalis (Osmundaceae, Polypodiopsida) and its relationship with bioclimatic variables
Authors: Lavilla Mikel , Seral Andrea , Murciano Antonio , Molino Sonia , De la Fuente Pablo , Gabriel y Galán Jose María 
Published: March 2020

Stomata are very conserved structures in plants, which allows and control the gas exchange. This ecophysiological fact appears to be critical in the ecology and adaptation of plants to environment. Plant individuals can, among other issues, adjust size and density of the stomata to adapt themselves to hydric, thermic and light regimes. In turn, this led to the reduction of transpiration and control of water losses, which is crucial in areas with Mediterranean climate. The fern Osmunda regalis has populations in both biogeographical regions of the Iberian Peninsula (Eurosiberian and Mediterranean regions), but when locations are highly continental the populations are scarce and isolated. The objective of this study is to characterize the stomatal morphological traits in both regions, to detect possible adaptations in individuals occurring in Mediterranean locations. 26 individuals of 17 different populations were sampled. Applying microscopic techniques, 4447 observations of length and width, and 234 of density and PCI were done. The sampling spots were characterized by two bioclimatic indices of Emberger and Gorzynski, and also mean maximum and minimum temperature values were obtained. All the information was included in a dataset that was statistically analyzed with the software SPSS. Our results show that Osmunda regalis fronds have higher PCI and density values in the Eurosiberian region, as expected. Gorczynski continentality index (K), and the mean maximum and minimum annual temperatures influences over stomatal traits. This is clearly informing that in the Mediterranean region, the temperature is an important factor that triggers stomatal adaptations of O. regalis to continental locations with higher levels of environmental stress. On the contrary, Emberger pluviometric index (Q) seems to be less explicative by its own. Perhaps this is related with the habitat of O. regalis in soils with high freatic level, fact which could lead to a more independent stomata from rainfall.
The 60s of the 20th Century: Modern Movement Public Catering Buildings in Latvia
Authors: Aizpurva Luīze Marta 
Published: March 2020

Abstract
The study summarizes information on buildings of catering establishments of the 1960s in Latvia. The analysis of the interior, exterior, location of the buildings as well as the possibilities for their restoration has been carried out. Information on the restoration and preservation of the Modern Movement architecture in the world has been analysed as well.
Effects of intermittent negative pressure and active recovery therapies in the post-match period in elite soccer players: A randomized, parallel arm, comparative study
Authors: Maior Alex Souto , Tannure Marcio , Eiras Fábio , de Sá Ferreira Arthur 
Published: March 2020

Summary

Study aim: This study compared the effects of intermittent negative pressure therapy (INPT) vs. active recovery therapy (ART) on post-match physiological parameters such as serum CK level and skin temperature of the lower limbs in elite soccer players.

Material and methods: Twenty healthy male professional soccer players from a Brazilian first division soccer club were enrolled in this randomized, parallel arm, open label, comparative study. After participating in 2 soccer matches, they were randomly assigned to two groups (n = 10) to receive a 30-min session of INPT (intermittent exchange of hypobaric pressure range 33 to 51 mmHg) or ART (self-myofascial release, mobility and stability exercises, and cycle ergometer exercise). The intervention was conducted after a match with assessments immediately before and after the intervention and again 24 h after the intervention.

Results: A significant interaction effect (F2,36 = 4.503, p = 0.018, η2 = 0.130) was observed, indicating that the decrease of CK from pre-intervention to 24 h post-intervention was greater in the INPT than in the ART group. Lower limb skin temperature was significantly lower after INPT than after ART (p < 0.003).

Conclusions: Serum CK level and skin temperature of lower limbs showed better recovery up to 24 h after the intervention with INPT in elite soccer players.
Infrared thermography mapping plus neuronavigation target location in an eloquent area cavernoma resection
Authors: de Font-Réaulx Enrique , López Ramón López , Díaz López Luis Guillermo 
Published: March 2020

Background:
Safety and efficacy are irrebuttable goals in neurosurgery.

Methods:
We performed a subcortical cavernoma resection in an eloquent area, where we recorded and compared the maximal and minimal brain temperature measured by an infrared thermographic camera and thermometer with the neuronavigation (NN) target location and real anatomical lesion location.

Results:
The hottest cortical point correlated to the subcortical cavernoma location. The NN located the target at 10 mm away from the hottest point.

Conclusion:
More studies are needed to better understand the thermic radiation of the brain in health and in disease, but we believe that evaluating brain temperature, it could be possible to improve accuracy in neurosurgery and generate more knowledge about brain metabolism in vivo.
Análise de Viabilidade Técnica da Aplicação de Energia Termossolar em Processos de Pasteurização
Authors: Silva Isaias Moura de Moraes , Gómez-Malagón Luis Arturo 
Published: March 2020

O aumento da demanda mundial por energia tem propiciado o desenvolvimento de tecnologias voltadas para o uso de fontes renováveis de energia, como por exemplo, a energia solar térmica. O uso do sol para aquecer a água é particularmente interessante para alguns ramos da indústria, onde se utiliza água numa temperatura entre 60ºC e 260ºC, como a indústria de alimentos. O Estado de Pernambuco dispõe de um Arranjo Produtivo Local (APL) de laticínios, localizada no agreste meridional e central, onde a energia empregada para aquecimento de água é obtida principalmente a partir da combustão da lenha, a qual gera impactos negativos para o meio ambiente. Com o intuito de identificar o potencial do uso da tecnologia termossolar no processo de pasteurização de leite, foi empregado o software TRNSYS para simular a resposta térmica de uma pequena planta solar térmica que poderia ser usada nessas indústrias. Foi verificado que, o sistema de coletores solares de tubos a vácuo acoplado a um tanque de armazenamento e um sistema de aquecimento convencional, atende as demandas de calor no processo de pasteurização. Desta forma, o uso da energia termossolar nas indústrias de pasteurização pode gerar benefícios econômicos, impactos positivos ao meio ambiente e diminuição dos riscos de operação e manuseio em comparação às caldeiras a lenha.
Aplikasi Computer Assisted Instruction (CAI) Pengenalan Hewan Berdasarkan Klasifikasi Makanan untuk Anak Berkebutuhan Khusus
Authors: Argo Hubertus Cahyo , Nyoto Rudi Dwi , Muhardi Hafiz 
Published: March 2020

Anak berkebutuhan khusus (ABK) adalah anak-anak abnormal yang menyandang ketunaan. Computer Assisted Instruction (CAI) adalah media bantu pembelajaran yang menempatkan komputer sebagai piranti sistem pembelajaran individual, siswa dapat berinteraksi langsung dengan sistem komputer yang dirancang. Dalam proses pembelajaran di sekolah berkebutuhan khusus, salah satu pembelajaran yang diajarkan adalah pengenalan tentang hewan dalam mata pelajaran IPA. Materi pengenalan hewan juga diajarkan dalam terapi wicara untuk anak berkebutuhan khusus. Pada proses materi pengenalan hewan terkadang anak berkebutuhan khusus mengalami kesulitan untuk memahami materi tersebut. Beberapa anak berkebutuhan khusus juga terkadang mengalami kesulitan dalam mengeja dan melafalkan nama hewan yang akan mereka pelajari. Selama ini alat penunjang yang guru gunakan hanya buku lembar kerja siswa (LKS) dan buku yang khusus memuat materi tentang pengenalan hewan. Untuk kasus tertentu, para terapis untuk anak berkebutuhan khusus menggunakan alat bantu berupa kartu bergambar untuk mengenalkan hewan-hewan yang akan dipelajari anak berkebutuhan khusus. Tujuan dari penelitian ini adalah untuk membantu anak berkebutuhan khusus lebih mudah belajar dan mengenali hewan, serta mengenalkan pelafalan nama hewan dan suara hewan tersebut dengan memanfaatkan konsep CAI dengan model tutorial dan instructional games. Pengujian aplikasi menggunakan uji validasi yaitu ahli materi (Guru SBK Bina Anak Bangsa), serta pengujian angket pada siswa SBK Bina Anak Bangsa dari kelas VI SD sampai XII SMA. Hasil yang didapat dari validasi aplikasi menggunakan skala pengukuran Guttman ini mendapatkan nilai 90% untuk sisi ahli materi, dan 88,9% untuk siswa SBK Bina Anak Bangsa, sehingga aplikasi CAI pengenalan hewan berdasarkan klasifikasi makanan untuk anak berkebutuhan khusus dirasa telah sesuai dengan tujuan dalam memenuhi target pembelajaran.
Aplikasi Learning Management System pada Jenjang Madrasah Aliyah
Authors: Istiyan Nur , Nyoto Rudy Dwi , Muhardi Hafiz 
Published: March 2020

Proses pembelajaran yang berlangsung di MAN 1 Kubu Raya memiliki beberapa kendala yaitu adanya keterbatasan waktu dalam penyampaian materi, evaluasi, dan pemahaman siswa yang berpengaruh terhadap hasil belajar siswa. Learning Management System (LMS) sebagai alternatif media pembelajaran untuk keperluan administrasi, dokumentasi, pencarian materi, laporan sebuah kegiatan, pemberian materi-materi pelatihan kegiatan belajar mengajar secara online yang terhubung ke internet. LMS berfungsi mengelola desain pembelajaran yakni membuat materi pembelajaran online berbasis web dan mengelola kegiatan pembelajaran serta hasil-hasilnya. Tujuan penelitian ini adalah untuk menghasilkan aplikasi Learning Management System pada jenjang Madrasah Aliyah serta mengetahui peningkatan hasil belajar siswa menggunakan media pembelajaran yang telah dikembangkan. Metode pengembangan sistem menggunakan konsep model SDLC air terjun (waterfall), konsep tersebut digunakan untuk perancangan sistem. Penelitian ini menggunakan pengujian User Acceptance Test (UAT) dan pre test – post test. Pengujian UAT dilakukan oleh ahli materi, pengajar, dan siswa untuk mengetahui kelayakan media pembelajaran yang telah dikembangkan. Sedangkan pre test – post test dilakukan menggunakan dua kelas untuk mengetahui adanya peningkatan hasil belajar siswa. Hasil penelitian menunjukkan bahwa media pembelajaran yang dikembangkan dinyatakan sangat layak berdasarkan hasil pengujian UAT oleh ahli materi dengan skor 91.42%, pengajar dengan skor 84.95%, dan siswa dengan skor 84.29%. Hasil analisis data pre test – post test menggunakan skor N-Gain terjadi peningkatan belajar siswa yang menggunakan media pembelajaran LMS yakni persentase peningkatan nilai sebesar 40.79% dengan kriteria sedang (medium) dimana skor g ≥ 0.3, sedangkan siswa yang menggunakan media pembelajaran tradisional yakni 15.93% dengan kriteria rendah (low) dimana skor g ˂ 0.3.
ẢNH HƯỞNG CỦA THỜI ĐIỂM THU HOẠCH VÀ PHƯƠNG PHÁP SẤY HẠTĐẾN CHẤT LƯỢNG GẠO CỦA GIỐNG LÚA RA DƯ VÀ A RI,ĐẶC SẢN ĐỊA PHƯƠNG THỪA THIÊN HUẾ
Authors: Long Nguyễn Tiến , Thủy Nguyễn Thi Thu , Hưng Hồ Công , Cơ Nguyễn Quang 
Published: March 2020

Tóm Tắt: Bài báo đánh giá chất lượng gạo sau xay xát, phẩm chất cơm và hàm lượng dinh dưỡng của hai giống lúa đặc sản địa phương Thừa Thiên Huế gồm Ra dư và A ri (trồng tại xã Hồng Quảng, huyện A Lưới, tỉnh Thừa Thiên Huế trong vụ Hè Thu năm 2018), đồng thời xác định thời điểm thu hoạch và phương pháp sấy hạt phù hợp nhất cho 2 giống lúa này. Kết quả cho thấytỷ lệ gạo nguyên của giống Ra dư và A ri đạt khá cao (lần lượt là 60,63% và 59,34%), độ bền gel cao (169 mm và 200 mm), giống có cơm mềm, hàm lượng dinh dưỡng cao như: sắt (38,0 và 187 mg/kg), omega 3 (35,9 và 29,4 mg/100g), omage 6 (787,9 và 793,1 mg/100g), omega 9 (697,1 và 955,4 mg/100g). Việc thu hoạch ở thời điểm 35 ngày sau trổ và sấy lúa ở 40 °C đến lúc độ ẩm của hạt đạt 14% cho tỷ lệ gạo nguyên 61,62% đối với giống Ra dư và 61,23% đối với giống A ri và chất lượng cơm cao hơn so với thu hoạch ở các thời điểm khác và phơi tự nhiên. Thời điểm thu hoạch và điều kiện sấy hạt này cho thấy hai giống Ra dư và A ri cho năng suất lý thuyết (51,67 và 51,87 tạ/ha) và năng suất thực thu (35,5 và 38,74 tạ/ha) cao nhất.Từ khóa: chất lượng gạo, thời điểm thu hoạch, phương thức sấy hạt, Ra dư, A ri
THE SPIRITUAL VALUES OF ROMAN CULTURE IN TWO CENTURIES OF THE PAX ROMANA PERIOD (27BC-180)
Authors: Lê Vũ Trường Giang Lê Vũ 
Published: March 2020

<p>The Pax Romana period was the pinnacle of ancient Roman culture since founding the country until the division into Eastern and Western Empire in 395. Only in two centuries, under the principate regime, Roman culture continues to create the available cultural roots of itself that inherited from the earlier generations; it selectively received and developed Greek foreign culture to a new point. All cultural values from the non-material to the material were constructed under the early dynasties of Augustus to the heyday of the Five Sage Kings or Aurelius who is both emperor and philosopher shows development and prosperity of Rome. Fields such as literature, history, science, philosophy,… have brilliant achievements. Rome has collapsed but Roman culture still lives in language, poetry, art of Latin, in the spirit of modern law and in the orderly traditions of the old European continent. </p>