bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing predictive accuracy in small samples using fixed‐smoothing asymptotics
Authors: Coroneo Laura , Iacone Fabrizio 
Published: March 2020

SummaryWe consider fixed‐smoothing asymptotics for the Diebold and Mariano (Journal of Business and Economic Statistics, 1995,13(3), 253–263) test of predictive accuracy. We show that this approach delivers predictive accuracy tests that are correctly sized even when only a small number of out‐of‐sample observations is available. We apply the fixed‐smoothing asymptotics to the Diebold and Mariano test to evaluate the predictive accuracy of the Survey of Professional Forecasters (SPF) and of the European Central Bank Survey of Professional Forecasters (ECB SPF) against a simple random walk. Our results show that the predictive abilities of the SPF and of the ECB SPF were partially spurious.
Peripheral vascular access for therapeutic plasma exchange: A practical approach to increased utilization and selecting the most appropriate vascular access
Authors: Barth David , Sanchez Amber , Thomsen Anna‐Marie , Garcia Alicia , Malachowski Roman , Weldon Rebecca , Mayhew Michaela , Mudie Kari , Faller Dawn , Schwartz Joseph 
Published: March 2020

AbstractBackgroundTherapeutic plasma exchange (TPE) is used in the treatment of many diseases. At present, peripheral vascular access (PVA) is an underutilized method of vascular access in TPE. It should be considered more frequently due its relatively low risk for adverse events, particularly infections.MethodsThe Advancing Vascular Access in Apheresis Working Group met in December 2017 for an extensive review and discussion of vascular access for TPE and developed a “road map” providing detailed information regarding clinical situations in which PVA‐based TPE would and would not be appropriate.ResultsThe road map is consistent with current recommendations that PVA should be used in combination with TPE whenever possible. PVA should be considered for patients who do not have existing central lines and who are stable. The patient should have peripheral veins that will allow for adequate treatment and must be able to comply with the process of achieving and maintaining peripheral access. There should be expert clinical assessment of veins, and this evaluation may include ultrasound and/or near infrared evaluation. Conditions that would prompt a switch from PVA to an alternate method of venous access include loss of venous access, patient preference, or development of a requirement for very frequent treatment over a long period of time.ConclusionsWhile PVA is not suitable for all patients requiring TPE, it has significant safety advantages over other approaches and should be employed whenever possible.
Association between anorexia of ageing and sarcopenia among Japanese older adults
Authors: Tsutsumimoto Kota , Doi Takehiko , Nakakubo Sho , Kim Minji , Kurita Satoshi , Ishii Hideaki , Shimada Hiroyuki 
Published: March 2020

AbstractBackgroundMalnutrition plays an essential role in the mechanism of pathogenesis for sarcopenia. In late life, both food consumption and energy intakes decline. One of key factors for reduced energy intakes is anorexia of ageing. The aim of this study is to examine the association between anorexia of ageing and sarcopenia among community‐dwelling elderly Japanese individuals.MethodsThis uses population‐based, cross‐sectional cohort study of elderly Japanese individuals. Anorexia of ageing was assessed via a simplified nutritional appetite questionnaire. Handgrip strength and walking speed were tested, and skeletal muscle mass was assessed using a bio‐impedance analysis device. Subjects with sarcopenia were defined as those who met the criteria of the Asian Working Group for Sarcopenia. The association between anorexia of ageing and sarcopenia was then analysed via multiple regression analysis.ResultsIn total, 9,496 elderly Japanese individuals were evaluated (mean age 74.1 ± 5.4 years; male, 47.0%). The prevalence of anorexia of ageing was 9.8% (n = 927) in the present study. The prevalence of sarcopenia in men was 1.1%, 1.8%, 6.1%, 10.1%, and 21.2% and was 1.6%, 3.3%, 3.6%, 4.8%, and 7.4% in women aged 65–69, 70–74, 75–79, 80–84, and 85 years and older, respectively. The prevalence of anorexia also showed an age‐dependent increase in both sexes (P < 0.001, respectively). The prevalence of anorexia in men was 8.3%, 6.3%, 9.8%, 13.6%, and 12.9% and was 7.9%, 9.4%, 10.5%, 17.6%, and 17.1% in women aged 65–69, 70–74, 75–79, 80–84, and 85 years and older, respectively. In multivariable logistic regression model adjusted for the covariates except for albumin, anorexia of ageing was independently associated with sarcopenia (OR: 1.45, 95% CI: 1.07 to 1.95; P = 0.015). This significant association remained even after adjusting for all covariates including nutritional status (OR: 1.42, 95% CI: 1.06 to 1.92, P = 0.020).ConclusionsAnorexia of ageing is associated with sarcopenia among Japanese elderly individuals. Further studies are needed to determine whether a causal association exists between anorexia and sarcopenia.
Antibacterial efficacy and remineralization capacity of glycyrrhizic acid added casein phosphopeptide‐amorphous calcium phosphate
Authors: Sahin Feride , Oznurhan Fatih 
Published: March 2020

AbstractThe aim was to evaluate remineralization capacity and antibacterial efficiency of Tooth Mousse and various amounts of glycyrrhizic acid added Tooth Mousse on primary tooth enamel. Three groups were formed; Group 1 (CPP‐ACP), Group 2 (CPP‐ACP + 5% glycyrrhizic acid), and Group 3 (CPP‐ACP + 10% glycyrrhizic acid) in order to evaluate remineralization capacity. Enamel samples were immersed in demineralization solution and then remineralization agents were applied. Surface microhardness and SEM analyses were performed at the beginning, after demineralization and remineralization. For antibacterial tests, four groups were formed; Group 1, Group 2 and Group 3 and Group 4 (control). Biofilms were then exposed to 10% sucrose eight times per day for 7 days. After biofilm growth period, samples were treated with materials to evaluate antibacterial efficiency except control group. After application of materials, samples were incubated 2 more days at 37°C and at the end of this period, absorbance values of biofilms were determined and data were analyzed. An increase in microhardness values was Group 2 > Group 3 > Group 1, respectively, but there were no significant differences. After remineralization, microhardness values showed significant increases when compared to demineralized groups, but there was no significant difference. All groups showed decreased absorbance value of biofilm when compared with control group but they were insignificant. It was observed that both in Group 2 and Group 3, glycyrrhizic acid did not have a negative effect on remineralization and although they have an increase, it was insignificant. Although glycyrrhizic acid added CPP‐ACP groups showed increased antibacterial activity, they were not statistically significant.
Reappraisal of the advantages of laparoscopic liver resection for intermediate hepatocellular carcinoma within a stage migration perspective: Propensity score analysis of the differential benefit
Authors: Ratti Francesca , Cipriani Federica , Fiorentini Guido , Catena Marco , Paganelli Michele , Aldrighetti Luca 
Published: March 2020

AbstractObjectiveThe aim of the present study was to analyze the outcome of laparoscopic approach specifically in patients with Intermediate‐stage disease and to define the differential benefit with Early‐stage patients.MethodsSix hundred twenty‐two resections for HCC were dichotomized according to staging (Early and Intermediate) and to approach and then matched in a 1:1 ratio using propensity scores to obtain four groups (E‐MILS and E‐Open, including 104 patients respectively; Int‐MILS and Int‐Open, including 142 patients, respectively). The differential benefit associated with the minimally invasive technique was evaluated between intermediate‐stage and early‐stage patients taking into account blood loss and morbidity rate as outcome indicators.ResultsLaparoscopic approach resulted in a statistically significant lower blood loss, reduced morbidity, reduced incidence of hepatic decompensation and shorter time for functional recover and length of stay. The evaluation of the differential benefit showed a greater advantage of laparoscopic approach in Intermediate‐stage patients compared with Early‐stage patients, both in terms of blood loss and morbidity rate.ConclusionsThe favorable biological scenario associated with laparoscopic approach allows to obtain enhanced benefits in the setting of more advanced liver disease. The push towards minimal invasiveness and the incremental benefit associated with it could potentially promote stage migration in suitable patients.
Field applicable detection of hepatitis B virus using internal controlled duplex recombinase‐aided amplification assay and lateral flow dipstick assay
Authors: Bai Xueding , Ma Xuejun , Li Minghui , Li Xinna , Fan Guohao , Zhang Ruiqing , Wang Ruihuan , Duan Qingxia , Shen Xinxin , Xie Yao , Rong Xiuge 
Published: March 2020

AbstractHepatitis B virus (HBV) is a widespread blood‐borne pathogen associated with the complication of liver cirrhosis and hepatocellular carcinoma, particularly in south‐east Asian and African countries where HBV is highly endemic and the budget and resources are limited. Therefore, simple, rapid, and portable field detection methods are crucial to efficiently control HBV infection. In this study, using heat‐treated DNA, we developed two‐field applicable detection assays for HBV based on recombinase‐aided amplification (RAA). One was an internal controlled duplex RAA assay using a portable real‐time fluorescence detection device, another was an instrument‐free visual observation assay using lateral flow dipsticks. The entire experimental time was greatly shortened to less than 40 minutes at 39.0°C. The sensitivities, specificities, and clinical performance of both assays were evaluated. Compared with quantitative polymerase chain reaction assay as a reference, our results demonstrated that the two RAA‐based assay obtained 97.18% and 95.77% of sensitivity, respectively, and the specificity was 100%, by testing a total of 157 serum samples with HBsAg positive. We conclude that the advantages of rapidity, simplicity, portability, and visualization of proposed two assays make them great potentials in point‐of‐care testing of HBV infection by untrained people in resource‐limited situations.
Nonlinear parameter of heart rate variability can diagnose early cardiac autonomic neuropathy
Authors: Dubey Pramita , Verma Manish , John Nitin Ashok , Gutch Manish 
Published: March 2020

AbstractThis is a case of a 63‐year‐old female presenting with diabetes mellitus, hypertension, hypothyroidism, and postmenopausal osteoporosis with findings showing abnormal AFT with reduced heart rate variability (HRV) and multiple lobed Poincaré plot, pointing to premature atrial contractions.
Phenethyl isothiocyanate synergistically induces apoptosis with Gefitinib in non–small cell lung cancer cells via endoplasmic reticulum stress‐mediated degradation of Mcl‐1
Authors: Zhang Qicheng , Chen Mengmeng , Cao Limin , Ren Yinghui , Guo Xueru , Wu Xiang , Xu Ke 
Published: March 2020

AbstractIsothiocyanates (ITCs) are natural compounds abundant in cruciferous vegetables. Numerous studies have shown that ITCs exhibit anticancer activity by affecting multiple pathways including apoptosis and oxidative stress, and are expected to be developed into novel anticancer drugs. In our previous studies, we demonstrated that ITCs effectively inhibit the proliferation of non–small cell lung cancer (NSCLC) cells, also induce apoptosis and autophagy. In the present study, we found that phenethyl isothiocyanate (PEITC) had significant synergistic effects with epidermal growth factor receptor tyrosine kinase inhibitor Gefitinib in NSCLC cell lines NCI‐H1299 and SK‐MES‐1; and the degradation of antiapoptotic factor myeloid cell leukemia 1 (Mcl‐1) caused by PEITC treatment played key roles in the sensitivity of NSCLC cells to Gefitinib. We further illustrated that PEITC regulated the expression of Mcl‐1 through protein kinase RNA‐like endoplasmic reticulum kinase (PERK)‐eukaryotic translation initiation factor 2α‐CHOP‐Noxa pathway by a posttranscriptional modulation. Pretreatment with endoplasmic reticulum stress (ER stress) inhibitor tauroursodeoxycholic acid and knockdown of PERK expression attenuated the degradation of Mcl‐1 caused by PEITC. In in vivo study, nude mice bearing NCI‐H1299 xenograft were administrated with PEITC (50 mg/kg, ip) and Gefitinib (50 mg/kg, ig) for 15 days, the PEITC‐Gefitinib combination treatment resulted in a significant synergistic reduction in tumor growth, and significantly induced both ER stress and Mcl‐1 degradation in tumor tissues. In conclusion, we explored the prospect of PEITC in improving the efficacy of targeted drug therapy and demonstrated the synergistic effects and underlined mechanisms of PEITC combined with Gefitinib in NSCLC cells treatment. This study provided useful information for developing novel therapy strategies by combination treatment of PEITC with targeted drugs.
Identification and characterization of novel SCR7‐based small‐molecule inhibitor of DNA end‐joining, SCR130 and its relevance in cancer therapeutics
Authors: Ray Ujjayinee , Raul Sanjay Kumar , Gopinatha Vindya K. , Ghosh Dipayan , Rangappa Kanchugarakoppal S. , Mantelingu Kempegowda , Raghavan Sathees C. 
Published: March 2020

AbstractTargeting DNA repair with small‐molecule inhibitors is an attractive strategy for cancer therapy. Majority of DNA double‐strand breaks in mammalian cells are repaired through nonhomologous end‐joining (NHEJ). It has been shown that small‐molecule inhibitors of NHEJ can block efficient repair inside cancer cells, leading to cell death. Previously, we have reported that SCR7, an inhibitor of NHEJ can induce tumor regression in mice. Later studies have shown that different forms of SCR7 can inhibit DNA end‐joining in Ligase IV‐dependent manner. Recently, we have derivatized SCR7 by introducing spiro ring into core structure. Here, we report the identification of a novel inhibitor of NHEJ, named SCR130 with 20‐fold higher efficacy in inducing cytotoxicity in cancer cell lines. SCR130 inhibited DNA end‐joining catalyzed by rat tissue extract. Specificity analysis revealed that while SCR130 was specific to Ligase IV, it showed minimal or no effect on Ligase III and Ligase I mediated joining. Importantly, SCR130 exhibited the least cytotoxicity in Ligase IV‐null cell line as compared with wild type, confirming Ligase IV‐specificity. Furthermore, we demonstrate that SCR130 can potentiate the effect of radiation in cancer cells when used in combination with γ‐radiation. Various cellular assays in conjunction with Western blot analysis revealed that treatment with SCR130 led to loss of mitochondrial membrane potential leading to cell death by activating both intrinsic and extrinsic pathways of apoptosis. Thus, we describe a novel inhibitor of NHEJ with higher efficacy and may have the potential to be developed as cancer therapeutic.
High surface area benzimidazole based porous covalent organic framework for removal of methylene blue from aqueous solutions
Authors: Rahmanian Omid , Falsafin Molood , Dinari Mohammad 
Published: March 2020

AbstractIn this study, a highly thermally stable benzimidazole based covalent organic framework (bCOF) was synthesized by the reaction of perlin‐tetracarboxylic anhydride, 5‐aminoisophthalic acid and diaminobenzidine in polyphosphoric acid medium. The synthesized porous bCOF was identified by different techniques. From CO2 adsorption, the micropore surface area of the bCOF was found to be 856 m2 g−1; this synthesized bCOF has a widespread netting construction, and it has various porosity. The TGA results displayed the high thermal strength of the synthesized bCOF. After characterization, the bCOF was used for the removal of methylene blue from aqueous solution, and the essential parameters such as pH of the solution, contact time and initial concentration were assessed. The maximum adsorption capacity of the bCOF for removal of methylene blue was 63.29 mg g−1 after only 40 min contact time at a pH of 6. Two kinetics and adsorption models were used for interpretation, and the outcomes showed that the pseudo‐second‐order and Langmuir models respectively were better fitted to the results. According to the results, the novel bCOF can be applied to remove methylene blue from aqueous solution. © 2020 Society of Chemical Industry
Combined Experimental and Density Functional Theoretical Studies of Am3+ and Eu3+ Extraction and Complexation with Different Nitrilotriacetamide (NTA) Derivatives
Authors: Bhattacharyya Arunasis , Mohapatra Prasanta K. , Kanekar Avinash S. , Dai Kun , Egberink Richard J. M. , Huskens Jurriaan , Verboom Willem 
Published: March 2020

AbstractN,N,N′,N′,N“,N”‐hexaalkylnitrilotriacetoamide (HRNTA) derivatives were found to be promising for the separation of trivalent actinides from lanthanides, which is a burning topic in the back end of the nuclear fuel cycle. In the present work, separation of Am3+ from Eu3+ was studied using the N,N,N’,N’,N’’,N’’‐hexa‐2‐ethylhexylnitrilotriacetamide (H2EHNTA) derivative and the role of the diluent medium to control the extractable complex was demonstrated. The effect of alkyl chain length and branching in the alkyl chain of different HRNTA (R=methyl, n‐butyl, n‐hexyl, n‐dodecyl and 2‐ethylhexyl) derivatives on their complexation with Eu3+ were investigated using steady‐state and time‐resolved luminescence studies. Different species formed at different ligand to metal ratios were identified from the luminescence titration experiments and their lifetime values measured. The experimental results were corroborated with the help of density functional theoretical (DFT) calculations on Am3+ and Eu3+ complexes of HRNTA derivatives with varying alkyl chain length and branching.
Spiro‐Indole‐Coumarin Hybrids: Synthesis, ADME, DFT, NBO Studies and In Silico Screening through Molecular Docking on DNA G‐Quadruplex
Authors: Khanna Leena , Singhal Sugandha , Jain Subhash C. , Khanna Pankaj 
Published: March 2020

AbstractNew series of hybrids were synthesized by combination of 4‐hydroxycoumarin with spiro[indol‐indazole‐thiazolidine]‐diones and spiro[indol‐pyrazole‐thiazolidine]‐diones, via hitherto unknown Schiff bases. The effects of substituents, such as ‐F, ‐Br and ‐CH3, on the crucial characteristics pertaining to the hybrids were investigated through computational studies. In silico or virtual screening through molecular docking studies on the library of 22 compounds, including reference compounds, precursors, non‐hybrid and hybrid derivatives, was performed on DNA G‐quadruplex of the human genome. All six freshly synthesized hybrids showed high binding energy as compared to non‐hybrids as well as reference compounds. The presence of substituents at 5‐position of indole enhanced the binding tendency of the ligand. ADME studies indicated good oral bioavailability and absorption of these compounds. Density Functional Theory (DFT) calculations of hybrids were done at B3LYP/6‐311G++(d,p) level of computation. Their HOMO and LUMO energy plots reflected the presence of high charge transfer and chemical potential. Natural bond order (NBO) calculations predicted hyperconjugative interactions. The Molecular Electrostatic Potential (MEP) surface plots showed possible electrophilic and nucleophilic attacking sites of the hybrids. Compound 10 a (5‐fluoro‐spiro[indol‐indazole‐thiazolidine]‐dione‐coumarin hybrid), on the basis of global reactivity descriptors, was filtered to be chemically most reactive with the highest binding energy of −8.23 kcal/mol with DNA G‐quadruplex. The synthesized hybrid coumarin derivatives in correlation with theoretical docking studies validate that hybrid derivatives are more reactive compared to their non‐hybrid counterparts.
Novel Pyruvate Kinase (PK) Inhibitors: New Target to Overcome Bacterial Resistance
Authors: El Sayed Mardia T. , Sarhan Alaadin E. , Ahmed Entsar , Khattab Reham R. , Elnaggar Mohamed , El‐Messery Shahenda M. , Shaldam Moataz A. , Hassan Ghada S. 
Published: March 2020

AbstractIn the present investigation, some novel nitro Mannich bases derived from Michael type addition of activated nitro olefin, β‐nitrostyrene with various amines either primary or secondary including some amino sugars were designed and synthesized. The produced Mannich bases have been full characterized through different spectroscopic techniques. Antimicrobial evaluation has been performed against the Gram positive S. aureus and methicillin‐resistant S. aurues (MRSA) infections. 5 of the synthesized compounds represent the best candidates in the biological screening, they have exhibited good activity with MIC values range from 100 to 250 μg/ml. The active agents have been tested for pyruvate kinase inhibition activity with % of inhibition range from 30 to 79 % with IC50 in a nano molar range. They also exhibited significant Pyruvate kinase inhibition in nanomolar range with IC50 of 1066, 662, 1887, 418 and 1128 ng/ml, respectively (versus 196 ng/ml for AZD7545). Molecular docking calculations for active agents were performed. A complete conformational analysis molecular modeling utilizing Gaussian 09 program (HF/DFT) was used to verify the mode of bonding through the optimized geometries as well as essential quantum parameters were calculated using frontier energies (EHOMO & ELUMO) for the active candidates indicating the overall stability of the structure.
High‐Performance Ultraviolet‐Visible Light‐Sensitive 2D‐MoS2/1D‐ZnO Heterostructure Photodetectors
Authors: Zhang Jian , Liu Yiting , Zhang Xinglai , Ma Zongyi , Li Jing , Zhang Cai , Shaikenova Altynay , Renat Beisenov , Liu Baodan 
Published: March 2020

AbstractTwo‐dimensional (2D) transition‐metal dichalcogenides (TMDs) such as molybdenum disulfide (MoS2) have recently attracted extensive interest for building future optoelectronic devices. However, the limited light absorption, low photoresponsivity and slow response speed in visible range inhibit their further application. Here, we proposed a promising approach to realize the high‐performance photodetectors (PDs) by constructing 2D‐MoS2 flake/1D‐ZnO nanowire mixed‐dimensional heterostructures. The integration of 1D‐ZnO on p‐type or n‐type MoS2 to form the mixed‐dimensional 2D‐MoS2/1D‐ZnO heterostructure PDs not only broadens the light response range, but also improves the photoresponsivity and response time of 2D‐MoS2 flakes. Under the 365 nm light illumination, the photoresponsivity, external quantum efficiency and response time of p‐MoS2/n‐ZnO PDs are as high as 24.36 A/W, 8.28×103 % and 0.9 s, respectively. Under 532 nm light illumination, the photoresponsivity, external quantum efficiency and response time are estimated to be 0.35 A/W, 80.9 % and 140 ms, respectively. These properties are superior or comparable to the performance of other reported 2D‐MoS2 flake PDs. This work provides a possible strategy for the realization of high‐performance optoelectronic devices by the integration of 2D‐MoS2 and 1D‐ZnO to form mixed‐dimensional heterostructures.