bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Diagnostic and Prognostic Values of MicroRNA-196a in Cancer
Authors: Xiong Mengqiu , Wang Ping , Pan Bei , Nie Junjie , Wang Shukui , He Bangshun 
Published: October 2020

Abstract
BackgroundmicroRNA-196a (miR-196a) was previously reported to be upregulated in cancers, and has the diagnostic and prognostic values in cancers. Whereas, the conclusion was still unclear according to the published data. To assess such a role of miR-196a in cancers, this study was conducted based on published data. MethodsTo identify the relevant published data, we searched articles in databases and then the relevant data was extracted to assess the correlation between miR-196a expression and diagnosis and survival for cancer patients, all data was analysis with the statistical software STATA. ResultsThe pooled results showed that miR-196a was a valuable diagnostic biomarker in cancer (AUC=0.87, 95%CI: 0.84-0.90; sensitivity=0.73, 95%CI:0.64-0.81; specificity=0.90, 95%CI:0.81-0.95), which was consistent with the data from databases (breast cancer: miR-196a-3p: AUC=0.77, 95%CI: 0.74-0.79; miR-196a-5p: AUC=0.71, 95%CI: 0.66-0.75; pancreatic cancer: miR-196a-3p: AUC=0.80, 95%CI: 0.73-0.87; miR-196a-5p: AUC=0.61, 95%CI:0.51-0.71). In addition, miR-196a in tissues was an unfavorable survival prognosis biomarker (HR=2.54, 95%CI: 1.79-3.61, PHeterogeneity =0.000, I2=75.8%) and serum or plasma (HR=4.06, 95%CI: 2.67-6.18, PHeterogeneity =0.668, I2=0%), which was consistent with the data from databases (adrenocortical carcinoma: HR=5.70; esophageal carcinoma: HR=1.93; brain lower grade glioma: HR=2.91; GSE40267: HR=2.47, 95%CI: 1.2-5.07; TCGA: HR=1.82, 95%CI: 1.21-2.74; GSE19783: HR=4.24, 95%CI:1-18.06). ConclusionOur results demonstrated that miR-196a acts as a tumor suppressor with prognostic and diagnostic values for cancer.
Impact of Rhythm-control Therapy for New-onset Atrial Fibrillation in Critically ill Patients : A Post Hoc Analysis From the Prospective Observational AFTER-ICU study
Authors: Yoshida Takuo , Uchino Shigehiko , Sasabuchi Yusuke , Kyo Michihito , Igarashi Takashi , Inoue Haruka 
Published: October 2020

Abstract
BackgroundSustained new-onset atrial fibrillation (AF) is time-dependently associated with hospital mortality. However, whether rhythm-control therapy can achieve sinus rhythm (SR) restoration in critically ill patients is unknown. This study aimed to assess the impact of rhythm-control therapy on SR restoration in critically ill patients with new-onset AF.MethodsThis study is a post hoc analysis of the AFTER-ICU study, a prospective observational study of patients with new-onset AF in 32 Japan intensive care units. This study included patients with and without rhythm-control therapy with new-onset AF. A multivariable analysis was performed using Cox proportional hazards regression analysis including rhythm-control therapy as a time-varying covariate for SR restoration.ResultsOf 423 patients with new-onset AF, 178 (42%) underwent rhythm-control therapy. Among those patients, 131 (31%) underwent rhythm-control therapy within 6 hours after AF onset. Magnesium sulfate was the most frequently used rhythm-control drug. The Cox proportional hazards model for SR restoration showed that rhythm-control therapy had a significant positive association with SR restoration (adjusted hazard ratio: 1.46; 95% confidence interval: 1.16–1.85). The rhythm-control group had higher hospital mortality than the non-rhythm-control group (31% vs. 23%, P=0.09).ConclusionsRhythm-control therapy for new-onset AF in critically ill patients was associated with SR restoration. However, patients with rhythm-control therapy had poorer prognosis, possibly due to selection bias. These findings may provide important insight for the design and feasibility of interventional studies assessing rhythm-control therapy in new-onset AF.Trial registrationUMIN-CTR UMIN000026401
Identification of Key Genes and Molecular Mechanisms Associated With Docetaxel Resistance in Castration Resistant Prostate Cancer Based on Bioinformatics Analysis
Authors: Liu Yu , Hu Changpeng , Zhang Qian , Liu Wuyi , Li Guobing , Tang Qin , Li Pantong , Lai Wenjing , Zhou Min , Liu Yali , Sheng Fangfang , Huang Jingbin , Zhou Huyue , Leng Faning , Li Furong , Zhang Rong , Zhao Yu 
Published: October 2020

Abstract
BackgroundCastration resistant prostate cancer (CRPC) is one of the most common solid tumor with high mortality and limited therapeutic options, and docetaxel is the first-line chemotherapy for patients. However, the long-term use of docetaxel has limited its clinical applications. The aim of this study was to identify docetaxel-resistant key genes and molecular mechanisms. ResultsTUBB4A (Class IVa beta-tubulin), SRPX (Sushi repeat containing protein, X chromosome) and CSRP2 (Cysteine and glycine rich protein 2) were finally identified as the key genes tightly related to docetaxel resistance. TUBB4A and CSRP2 may participate in docetaxel resistance by E2F transcription factor and MYC proto-Oncogene in the process of cell cycle, and SRPX may participate in docetaxel resistance by epithelial–mesenchymal transition (EMT) and P53 pathway. ConclusionTUBB4A, SRPX and CSRP2 may be the key genes associated with docetaxel resistance, which could be prognostic biomarkers for docetaxel resistance in CRPC.
CoPart: A Context-based Partitioning Technique for Big Data
Authors: Migliorini Sara , Belussi Alberto , Quintarelli Elisa , Carra Damiano 
Published: October 2020

Abstract
The MapReduce programming paradigm is frequently used in order to process and analyse huge amount of data. This paradigm relies on the ability to apply the same operation in parallel on independent chunks of data. The consequence is that the overall performances greatly depend on the way data are partitioned among the various computation nodes. The default partitioning technique provided by systems like Hadoop or Spark, basically performs a random subdivision of the input records, without considering the nature and correlation between them. Even if such approach can be appropriate in the simplest case where all the input records have to be always analysed, it becomes a limit for sophisticated analyses that imply correlations between records that can be exploited to preliminary prune unnecessary computations.In this paper we propose a partitioning technique which exploits the notion of context for partitioning data. We design a context-based multi-dimensional partitioning technique, called \copart, which considers not only the correlation of data w.r.t. contextual attributes, but also the distribution of each contextual dimension in the dataset. We experimentally compare our approach with existing ones, considering both quality criteria and the query execution times.
Applying the electronic nose for pre-operative SARS-CoV-2 screening
Authors: Wintjens Anne G.W.E. , Hintzen Kim F.H. , Engelen Sanne M.E. , Lubbers Tim , Savelkoul Paul H.M. , Wesseling Geertjan , Palen Job A.M. van der , Bouvy Nicole D. 
Published: October 2020

Abstract
Background: Infection with SARS-CoV-2 causes Corona Virus Disease (COVID-19). The most standard diagnostic method is reverse transcription-polymerase chain reaction (RT-PCR) on a nasopharyngeal and/or an oropharyngeal swab. The high occurrence of false-negative results due to the non-presence of SARS-CoV-2 in the oropharyngeal environment renders this sampling method not ideal. Therefore, a new sampling device is desirable. This proof-of-principle study investigated the possibility to train machine-learning classifiers with an electronic nose (Aeonose) to differentiate between COVID-19 positive- and negative persons based on volatile organic compounds (VOCs) analysis.Methods: Between April and June 2020, participants were invited for breath analysis when a swab for RT-PCR was collected. If the RT-PCR resulted negative, presence of SARS-CoV-2 specific antibodies was checked to confirm the negative result. All participants breathed through the Aeonose for five minutes. This device contains metal-oxide sensors that change in conductivity upon reaction with VOCs in exhaled breath. These conductivity changes are input data for machine-learning and used for pattern recognition. The result is a value between -1 and +1, indicating the infection probability.Results: 219 participants were included, 57 of which COVID-19 positive. A sensitivity of 0.86 and a negative predictive value (NPV) of 0.92 were found. Adding clinical variables to machine-learning classifier via multivariate logistic regression analysis, the NPV improved to 0.96. Conclusions: The Aeonose can distinguish COVID-19 positive from negative participants based on VOC patterns in exhaled breath with a high NPV. The Aeonose might be a promising, non-invasive, and low-cost triage tool for excluding SARS-CoV-2 infection in patients elected for surgery.
A Method to Access a Decimal Network (IPV9) Resource
Authors: Liu Guangzhou , Yu Fuya 
Published: October 2020

Abstract
Network security is highly valued by world leaders. The current Internet technology core is IPv4, IPv6, completely controlled by the United States. On December 14, 2017, the US Federal Communications Commission (FCC) formally abolished the net neutrality law. At that time, the Internet took on an obvious political color and posed a serious threat to Internet applications in various countries. China’s economy is already highly dependent on the Internet, and if the network is disrupted, the whole country will suffer heavy losses. The decimal Network Standard working Group of The Ministry of Industry and Information Technology of China and The Decimal Network Information Technology Co., LTD of Shanghai have been researching on the future network for more than 20 years. Developed a complete set of decimal network framework system, completed the future network series research and development with China’s independent intellectual property rights, and built the second Internet network system besides the United States. The technology has been fully tested in many places and achieved good results, truly achieving the goal of “autonomy, safety, high speed and compatibility”. This paper will introduce the method of accessing decimal network resources in the current network environment.
Expression of gene involved in the response to abiotic factors in Capsicum annuum
Authors: Ríos Molina Dafne Alejandra , Aquino Medina Edgar Querubín , Couoh Uicab Yeny L. , Guevara Olvera Lorenzo , Silva Martínez Guillermo A. , Acosta García Gerardo , Ramírez Medina Humberto 
Published: October 2020

Introduction: Abiotic stress caused by cold or water-deficit alters many cellular processes that modificate the physiology and biochemistry of plants, which reduces yield of agricultural crops. Gibberellins are phytohormones that can induce growth and development of the plants. There are many genes whose transcription is modified during abiotic stress or by exogenous-gibberellins application; some of them encode for proteins such as LEA that confer protection against low temperature and dehydration, WRKY and FT that take part in the response to abiotic stress, FT that regulates the flowering time, and GA20ox1 that synthesized gibberellins. The understanding of molecular mechanism that regulates the plant responses to abiotic stress or exogenous gibberellins application is essential for Capsicum annuum (pepper) agriculture improvement. To this aim, we have proceeded to study the effect of biotic stress and exogenous phytohormones on C. annuum development, mainly in fruit (chili) production and expression of genes involved in the response to these conditions.Method: The genome of Capsicum annuum contains homologues to the proteins LEA, WRKY, FT and GA20oxy, so we estimate by Real-Time PCR (qPCR) and phenotype analysis, the gene expression and fruits production in plants grown under abiotic stress and after treatment with exogenous gibberellins.Results: The transcripts of CaLea73 and CaWRKY40 increased by cold stress in leaves. While, CaGA20ox1 expression was down-regulated by cold stress, GA3, and hydric stress-GA3 in leaves. This effect was also observed in flower buds of plants grown under water-deficit, treated with gibberellins or hydric stress-GA3; curiously, the transcripts from this gene became slightly abundant in plants grown under water-deficit. CaFT transcription was induced by cold stress and GA3 in leaves and flower buds, respectively; however, transcription of this gene was almost abolished by hydric stress and GA3–hydric stress in both tissues. Cold stress and exogenous phytohormones raised the fruits production.Conclusion: According with these results, we propose that cold treatment induces the plant defense mechanisms through activation of transcription factors like WRKYs and LEA proteins and increases the plant development through induction of signaling pathway of FT. Our study contributes to understanding on molecular mechanisms governing the responses to abiotic stress and the participation of the gibberellins in C. annuum development and to improve the yield of the chili crop.
Backpack use as an alternative water transport method in Kisumu, Kenya
Authors: Kim Sunkyung , Curran Kathryn , Deng Li , Odhiambo Aloyce , Oremo Jared , Otieno Ronald , Omore Richard , Handzel Thomas , Quick Robert 
Published: October 2020

Abstract
In developing countries, most households transport water from distant sources, placing physical burdens on women and children, who commonly carry water on their heads. A lightweight backpack was developed to alleviate physical stress from water carriage and provide a safe storage container. In 2015, we conducted a baseline survey among 251 Kenyan households with children &lt;5 years old, distributed one backpack per household, and made 6 monthly home visits to ask about backpack use. At baseline, the median reported water collection time was 40 minutes/round trip; 80% of households reported collecting water daily (median 3 times/day). At follow-up visits, respondents reported backpack use to carry water ranged from 4% to 20% in the previous day; reported backpack use for water storage in the previous day ranged from 31% to 67%. Pain from water carriage was reported at 9% of all follow-up visits. The odds of backpack use in the past day to collect water were lower during rainy season (OR: 0.3, 95% CI: 0.2–0.3) and not associated with reported pain (OR: 1.7, 95% CI: 0.9–3.3). Our study suggests that participants preferred using the backpacks for storage rather than transport of water. Further dissemination of the backpacks is not recommended because of modest use for transport.
Treatment of high viscosity fracturing flowback by electrolytic brine-catalyzed oxidation
Authors: Si Shaoxiong , Gong Zhaobo , Yang Yongxia , Liu Shengli , Wang Yu , Wang Xinghua 
Published: October 2020

AbstractWith the increasing application of hydraulic fracturing technology in exploration of tight oil and shale gas, the treatment of accompanying fracturing flowback fluids has become more urgent. Fe/Ni catalyst was successfully applied in the treatment of the flowback fluid for the first time in this paper. The effects of different oxidants and catalysts on the treatment of fracturing flowback were investigated. Electrolytic brine was an optimal oxidation gel breaker and molecular sieve loaded with Fe/Ni as catalyst for the treatment of fracturing flowback. Fe/Ni catalyst was characterized by SEM, EDS analysis, TEM and XRD, and the catalytic effect of the Fe/Ni proportion was explored. Fracturing flowback that dealt with catalytic oxidation was mixed with polyaluminum chloride (PAC) and polyacrylamide (PAM) for flocculation and sedimentation, through a filter, and was continuously treated for 20 days to simulate on-site operation. Finally, the suspended solids (SS) content of the fracturing flowback was steadily less than 15 mg/L, which meets the reinjection standard of fracturing flowback (SY/T 5329-2012 (China)). Hence, electrolytic brine-catalyzed oxidation treatment of high viscosity fracturing flowback possess broad application prospects.
Multi-Target Directed Compounds with Antioxidant and/or Anti- Inflammatory Properties as Potent Agents for Alzheimer’s Disease
Authors: Papagiouvannis Georgios , Theodosis-Nobelos Panagiotis , Kourounakis Panos N. , Rekka Eleni A. 
Published: October 2020

Background:
Alzheimer’s Disease (AD) is one of the most common neurodegenerative
disorders, characterized by memory deficits and cognitive impairment. Acetylcholinesterase inhibitors,
NMDA receptor antagonists and nootropic agents are used clinically, but they have only symptomatic
efficacy, attributed to the multifactorial character of AD. The multi-target directed compound
approach is gaining attention and has been under investigation lately.

Objective:
This review selects several research articles, which describe the design, synthesis and biological
evaluation of multi-targeting molecules combining antioxidant or/and anti-inflammatory
properties. Compounds with these properties are expected to be beneficial in the treatment of AD.

Methods:
This review summarizes the pathobiochemistry of AD as well as the role of oxidative stress
and inflammation in the progression of neurodegeneration. It presents novel compounds with antioxidant
or/and anti-inflammatory activity that have been tested for their efficacy in neurodegenerative
disorders.

Results:
Various researchers have taken advantage of the multi-targeting drug approach in order to
design molecules which may be developed as useful agents for the treatment of neurodegeneration.

Conclusion:
The multi-targeting compound approach is a developing therapeutic strategy for multifactorial
diseases, such as AD, and can offer effective agents for their radical treatment.
Public Opinion About E-Cigarettes on Chinese Social Media: A Combined Study of Text Mining Analysis and Correspondence Analysis
Authors: Wang Di , Lyu Joanne Chen , Zhao Xiaoyu 
Published: October 2020

Background
Electronic cigarettes (e-cigarettes) have become increasingly popular. China has accelerated its legislation on e-cigarettes in recent years by issuing two policies to regulate their use: the first on August 26, 2018, and the second on November 1, 2019. Social media provide an efficient platform to access information on the public opinion of e-cigarettes.

Objective
To gain insight into how policies have influenced the reaction of the Chinese public to e-cigarettes, this study aims to understand what the Chinese public say about e-cigarettes and how the focus of discussion might have changed in the context of policy implementation.

Methods
This study uses a combination of text mining and correspondence analysis to content analyze 1160 e-cigarette–related questions and their corresponding answers from Zhihu, China’s largest question-and-answer platform and one of the country’s most trustworthy social media sources. From January 1, 2017, to December 31, 2019, Python was used to text mine the most frequently used words and phrases in public e-cigarette discussions on Zhihu. The correspondence analysis was used to examine the similarities and differences between high-frequency words and phrases across 3 periods (ie, January 1, 2017, to August 27, 2018; August 28, 2018, to October 31, 2019; and November 1, 2019, to January 1, 2020).

Results
The results of the study showed that the consistent themes across time were comparisons with traditional cigarettes, health concerns, and how to choose e-cigarette products. The issuance of government policies on e-cigarettes led to a change in the focus of public discussion. The discussion of e-cigarettes in period 1 mainly focused on the use and experience of e-cigarettes. In period 2, the public’s attention was not only on the substances related to e-cigarettes but also on the smoking cessation functions of e-cigarettes. In period 3, the public shifted their attention to the e-cigarette industry and government policy on the banning of e-cigarette sales to minors.

Conclusions
Social media are an informative source, which can help policy makers and public health professionals understand the public’s concerns over and understanding of e-cigarettes. When there was little regulation, public discussion was greatly influenced by industry claims about e-cigarettes; however, once e-cigarette policies were issued, these policies, to a large extent, set the agenda for public discussion. In addition, media reporting of these policies might have greatly influenced the way e-cigarette policies were discussed. Therefore, monitoring e-cigarette discussions on social media and responding to them in a timely manner will both help improve the public’s e-cigarette literacy and facilitate the implementation of e-cigarette–related policies.
Sosiaalialan ammattilaiset halukkaita osallistumaan asiakastietojärjestelmien kehittämiseen – osallistumistavoissa kehitettävää
Authors: Martikainen Susanna , Salovaara Susi , Ylönen Katri , Tynkkynen Elina , Kaipio Johanna , Tyllinen Mari , Lääveri Tinja 
Published: October 2020

Tietojärjestelmien kehittämistyön lähtökohtana tulee olla vahva ymmärrys käyttäjien tarpeista, tehtävistä sekä toimintaympäristöstä. Lisäksi suunnitteluratkaisuja tulee arvioida käyttäjien kanssa kehittämisprosessin aikana ja käyttöönoton jälkeen. Vaikka kansallisesti kohdennetaan runsaasti resursseja tietojärjestelmäpalveluiden kehittämiseen, sosiaalialalta tutkimusta aiheesta löytyy niukasti.
Sosiaalialan ammattilaisten kokemuksia asiakastietojärjestelmien kehittämistyöstä kartoitettiin osana keväällä 2019 toteutettua valtakunnallisesta käyttäjäkokemuskyselyä. Kysymyksissä käsiteltiin kokemuksia yhteistyöstä tietojärjestelmätoimittajan kanssa, osallistumisesta kehittämistyöhön ja osallistumistavoista tietojärjestelmien kehitykseen. Tuloksia tarkasteltiin asiakastietojärjestelmän tuotemerkeittäin.
Puolet vastaajista ei ollut osallistunut lainkaan kehittämistyöhön, mutta vain 19% ei ollut halukkaita osallistumaan ollenkaan. Suosituimmat osallistumistavat olivat ongelmien raportointi järjestelmien kehittämisen vastuuhenkilölle ja oman työn esittely kehittäjille; sen sijaan tietojärjestelmätoimittajien yleisimmin käyttämät tavat eli palautteen kirjaaminen verkkosivustolle tai sähköpostiin eivät olleet käyttäjien mieleen. Suurin osa tiesi, miten ongelmatilanteista ja kehitysehdotuksista raportoidaan.
Sosiaalialan ammattilaiset ovat kiinnostuneita osallistumaan kehittämistyöhön, mutta he eivät ole tyytyväisiä mahdollisuuksiin ja tapoihin osallistua käyttämiensä järjestelmien kehittämiseen. Järjestelmätoimittajien ja käyttäjien väliltä puuttuvat sopivat toimintatavat. Tulokset ovat samansuuntaisia kuin vastaavissa lääkäreille ja sairaanhoitajille tehdyissä tutkimuksissa. On myös mahdollista, että organisaatiot eivät hyödynnä innokasta kehittäjäpotentiaalia. Kehittäjien tulee jalkautua kentälle ja organisaatioiden palkata tietojärjestelmäkehityksestä vastaavia ammattilaisia tulkeiksi järjestelmätoimittajan ja käyttäjien välille. Sosiaalialan ammattilaisten näkökulma on huomioitava vahvemmin järjestelmäkehityksessä, jotta tietojärjestelmät saadaan onnistuneesti tukemaan sote-yhteistyötä tulevaisuudessa.