bluuebunny/crossref_metadata_2025_split huggingface dataset:
HLA-B27 typing by use of flow cytofluorometry.
Authors: Albrecht J , Müller H A 
Published: February 2020

Abstract
We describe the use of flow cytofluorometry to type lymphocytes for HLA-B27 antigens. We modified the cytotoxicity test of Terasaki and McClelland [Nature (London) 1964;204:998] for use with a flow cytofluorometer. In a second assay we used a commercially available monoclonal anti-HLA-B27 antibody and indirect immunofluorescence staining of cell surfaces. Although this antibody cross reacts with B7 and Bw22 antigens, the results for HLA-B27 and the cross-reacting antigens can be separated. Comparison of our results with those by a HLA-typing laboratory for 100 patients showed total agreement of the assigned typings.
Assay of disaturated phosphatidylcholine in amniotic fluid as a test of fetal lung maturity: experience with 2000 analyses.
Authors: Tsai M Y , Shultz E K , Williams P P , Bendel R , Butler J , Farb H , Wager G , Knox E G , Julian T , Thompson T R 
Published: February 2020

Abstract
We determined concentrations of disaturated phosphatidylcholine (DSPC) in nearly 2000 amniotic fluid samples obtained either transabdominally or as vaginal pools. Here we report our comparison of these DSPC values with the lecithin/sphingomyelin (L/S) ratios for amniotic fluid samples obtained from diabetic and nondiabetic pregnancies and also between transabdominally or vaginally collected samples uncontaminated by blood or meconium. DSPC measurement is at least as good as the L/S ratio in predicting the absence of respiratory distress syndrome. DSPC concentrations were, however, lower in diabetic than in nondiabetic pregnancies, supporting the hypothesis that DSPC synthesis may be impaired in fetuses of diabetic mothers. Visually uncontaminated samples collected transabdominally or vaginally, when grouped according to length of gestation, have similar DSPC values but different L/S ratios. Thus, even in the absence of blood or meconium, DSPC may be a more useful test than the L/S ratio for vaginally pooled samples.
Comparison of long-term mortality between living alone patients vs. living together patients with acute coronary syndrome treated with percutaneous coronary intervention
Authors: Takeuchi Mitsuhiro , Ogita Manabu , Wada Hideki , Takahashi Daigo , Nozaki Yui , Nishio Ryota , Yasuda Kentaro , Takahashi Norihito , Sonoda Taketo , Yatsu Shoichiro , Shitara Jun , Tsuboi Shuta , Dohi Tomotaka , Suwa Satoru , Miyauchi Katsumi , Daida Hiroyuki 
Published: February 2020

Abstract

Aims
Living alone is reported as an independent risk factor for cardiovascular disease. However, little is known about the association between clinical outcomes and living alone in patients with acute coronary syndrome (ACS). The aim of this study was to determine whether living alone is an independent prognostic risk factor for long-term mortality stratified by age in patients with ACS who were treated with primary percutaneous coronary intervention (PCI).

Methods and results
We conducted an observational cohort study of ACS patients who underwent PCI between January 1999 and May 2015 at Juntendo University Shizuoka Hospital, Japan. The primary endpoint was all-cause death. Among 2547 ACS patients, 381 (15.0%) patients were living alone at the onset of ACS. The cumulative incidence of all-cause death was comparable between living alone and living together (34.8% vs. 34.4%, log-rank P = 0.63). However, among younger population (aged &lt;65 years), the incidence of all-cause death was significantly higher in the living alone group (log-rank P = 0.01). Multivariate Cox hazard analysis revealed a significant association between living alone and all-cause death, even after adjusting for other risk factors (hazard ratio 2.30, 95% confidence interval 1.38–3.84, P = 0.001).

Conclusion
Although living alone was not significantly associated with long-term clinical outcomes in patients with ACS, it was a predictive risk factor among younger ACS patients. Careful attention should be paid to patients’ lifestyle, especially younger patients with ACS.
Electrical conductivity in the mantle transition zone beneath Eastern China derived from L1-Norm C-responses
Authors: Zhang Yanhui , Weng Aihua , Li Shiwen , Yang Yue , Tang Yu , Liu Yunhe 
Published: February 2020

SUMMARY
Constraining the distribution of water in different regions of the mantle remains one of the significant challenges to comprehend the global deep water cycle. Geomagnetic depth soundings can provide such constraint through the electrical conductivity structure. Hence, this study aims to propose a regularization technique that can estimate previously unavailable C-response. In the method, the objective function comprised an L1-norm measured data prediction error and a spectral smoothness constraint term. We used the data error of C-response to weight the predicted error. The L-BFGS method was introduced to determine the minimum point of the objective function, and the regularization parameter decreased adaptively during inversion. Thus, the geomagnetic data processed yielded high-quality C-responses in 31 stations in Eastern China. In addition, we obtained 1-D electrical conductivity profiles in the mantle transition zone (MTZ) beneath Eastern China from C-responses using the L-BFGS method. Compared with the global 1-D model, the conductivity–depth profiles revealed that the MTZ beneath Eastern China is more conductive in the east but more resistive in the west. The conversion of these conductivities to water content based on the mineral physics suggested that the MTZ beneath Eastern China is characterized by a high water concentration, approximately 0.2 and 1 wt per cent in the upper and lower MTZ, respectively. Owing to the inclusion of more stations, the water-rich region could be constrained roughly to the east of the North–South Gravity Lineament (NSGL). Further considering seismic images in the same area, this water content distribution pattern suggested that the front of the stagnant Pacific Plate in the lower MTZ might have reached the NSGL. However, the dehydration reactions in the stagnant slab were more active in the eastern part. Perhaps, some of these fluids migrated into the upper MTZ and could be the source of the trapped water found in the xenoliths from the deep upper mantle beneath Eastern China.
Flow plane orientation in the upper mantle under the Western/Central United States from SKS shear-wave splitting observations
Authors: Löberich Eric , Bokelmann Götz 
Published: February 2020

SUMMARY
The causes of seismic anisotropy are still under debate. In particular, it is important to understand the extent to which seismic anisotropy is due to more recent geodynamic activities in the asthenosphere, or to frozen-in deformation in the lithosphere. We show that these two endmember cases can in principle be distinguished using shear-wave splitting observations from SKS waves. This is illustrated by the simple example of pure olivine with horizontal a-axis, and differing orientations of the other two axes, namely, vertical b and vertical c. The azimuthal dependence of shear-wave splitting measurements is described by two parameters, which can provide additional information about subsurface deformation. In particular, the oscillation parameter d1 constrains the orientation of foliation. We demonstrate that shear-wave splitting in the Western and Central United States indeed shows the predicted azimuthal dependence, related to a mainly subhorizontally oriented flow plane of deformation in the upper mantle. This has important implications for asthenospheric flow.
The welfare and productivity of sows and piglets in group lactation from 7, 10, or 14 d postpartum
Authors: Verdon Megan , Morrison Rebecca S , Rault Jean-Loup 
Published: February 2020

Abstract
Transferring sows and their litters to group lactation (GL) after an initial period of farrowing crate (FC) housing could enhance the viability of GL for commercial production. Group lactation from 7 d postpartum would reduce the time sows spend in confinement, but the effects of early mixing on animal welfare and productivity require examination. Two experiments were conducted on sows and piglets kept in GL from 7, 10, or 14 d postpartum, compared with FC. Experiment 1 utilized 180 sows and 1,887 piglets over five time replicates (n = 60 sow and litter units per treatment) comparing GL from 7 or 14 d postpartum to FC. In experiment 2, 108 sows and 1,179 piglets were studied over three time replicates (n = 36 sow and litter units per treatment) comparing GL from 10 or 14 d postpartum to FC. All sows farrowed in FC. Group lactation sows were transferred to pens (one pen of five sows at 8.4 m2/sow and one pen of seven sows at 8.1 m2/sow, per GL treatment and replicate) with their litters at 7 (GL7), 10 (GL10), or 14 (GL14) d postpartum. Farrowing crate sows and their litters remained in their FC. Data were collected on sow feed intake and reproduction, piglet mortality (from day 6 postpartum), and sow and piglet weight changes, plasma cortisol concentrations, and injuries. Piglet mortality was greater in the GL7 (17 ± 1.8%) and GL10 treatments (12 ± 0.9%) compared with GL14 (8.3 ± 1.8% P ≤ 0.001 and 8.1 ± 0.9% P ≤ 0.001 in experiments 1 and 2), and greater in GL overall compared with FC (2.7 ± 1.5% and 1.8 ± 0.9% in FC in experiments 1 and 2; P ≤ 0.001). Piglets from GL7 were also lighter at weaning than GL14 piglets (P &lt; 0.001), whereas GL10 and GL14 did not differ (P &gt; 0.05). Overall, piglets in GL were lighter at weaning than piglets in FC (P ≤ 0.01). Sows from GL7 were heavier at weaning (P = 0.001), and GL10 sows tended to be heavier at weaning (P = 0.08), than GL14 and FC sows. Post-mixing, sow cortisol (P ≤ 0.01) and sow and piglet injuries (P ≤ 0.02) were greater in GL than FC. Treatment had no effect on sow feed intake or reproductive performance (P &gt; 0.05). Under the conditions of this research, the known benefits of two-stage GL housing were achieved at a cost particularly to piglets in terms of increased piglet mortality and injuries after mixing, and reduced piglet growth. The risk of piglet mortality decreased with older age at mixing.
Fitting CAD data to scanned data with large deformation☆
Authors: Suzuki Shintaro , Ohtake Yutaka , Suzuki Hiromasa 
Published: February 2020

Abstract
Recently, largely deformed simulation models, such as car crash simulations, have been in high demand. To evaluate such models, it is necessary to use actual deformation results to compare and validate them. When measuring actual deformed objects, an X-ray CT is useful because it is non-destructive. However, matching undeformed CAD data and scanned deformation data is difficult. We propose a system for users to set control points or control lines on feature points and predict deformation using affine transformation with the moving least squares method. In the proposed method, undesirable distortions are reduced by evaluating scaling using singular value index and introducing offset control points. The deformed CAD data are obtained by matching predicted CAD data and a polygon mesh generated by deformed CT data. In addition, the surface elements of the generated deformed CAD data are evaluated for CAE.
Large-Scale Operational Pyriproxyfen Autodissemination Deployment to Suppress the Immature Asian Tiger Mosquito (Diptera: Culicidae) Populations
Authors: Unlu Isik , Rochlin Ilia , Suman Devi S , Wang Yi , Chandel Kshitij , Gaugler Randy 
Published: February 2020

Abstract
Effective suppression of container-inhabiting Asian Tiger [Aedes albopictus (Skuse)] (Diptera: Culicidae) and yellow fever [Aedes aegypti (L.)] (Diptera: Culicidae) mosquitoes presents one of the most intractable problems for modern mosquito control. Traditional tools often fail to control populations of these mosquito species, and are prohibitively expensive or have negative environmental impacts. Novel approaches and tools are urgently needed for integrated container-inhabiting mosquito management programs. One of the most promising techniques is autodissemination. We present the results of a long-term large-scale study conducted in a temperate urbanized environment representing typical Ae. albopictus habitats. Three treatment sites with autodissemination stations and three nearby reference sites were monitored for eggs, immature, and adult mosquitoes over a period of 3 yr from 2014 to 2016. Elevated larval and pupal mortality of 12–19% on average was the most notable outcome in sentinel cups of the treatment sites. The number of eggs in the treatment sites was significantly reduced in 2014, but not in 2015 or 2016. Adult populations remained similar in treatment and reference sites throughout the study. The impact of autodissemination on mosquito populations was lower than reported by previous investigations. Technical and logistical problems associated with wider coverage and working in multiple urban neighborhoods contributed to reduced efficacy. Incorporating autodissemination with routine mosquito control operations and commercializing this methodology for general public use will require further research on combining this tool with other novel or conventional technologies.
Macrophyte Diversity and Complexity Reduce Larval Mosquito Abundance
Authors: Lumpkin Will P , Stirek Kincade R , Dyer Lee A 
Published: February 2020

Abstract
The role of aquatic arthropod diversity and community interactions of larval mosquitoes are important for understanding mosquito population dynamics. We tested the effects of aquatic macrophyte diversity and habitat structural complexity in shaping the predator and competitor invertebrate communities associated with mosquito larvae. Experimental mesocosms were planted with live aquatic macrophytes and allowed to be naturally colonized by local invertebrates. Results indicated a positive effect of macrophyte diversity on competitor diversity and a negative effect on predator diversity. In turn, predator diversity negatively impacted mosquito abundance through a direct effect, while competitor diversity showed an indirect negative effect on mosquito larval abundance through its positive effect on predator diversity. The enhancement of aquatic macrophyte diversity and structural complexity has practical applications for the reduction of mosquito populations in managed systems where complete source elimination is not possible.
Small-Molecule Inhibitors of Inward Rectifier Potassium (Kir) Channels Reduce Bloodmeal Feeding and Have Insecticidal Activity Against the Horn Fly (Diptera: Muscidae)
Authors: Li Zhilin , Guerrero Felix , Pérez de León Adalberto A , Foil Lane D , Swale Daniel R 
Published: February 2020

AbstractBloodmeal feeding by the horn fly, Haematobia irritans (L.), is associated with reduced milk production and blood loss that ultimately prevents weight gain of calves and yearlings. Thus, blood feeding by H. irritans causes significant economic losses in several continents. As with other arthropods, resistance to the majority of commercialized insecticides reduces the efficacy of current control programs. Thus, innovative technologies and novel biochemical targets for horn fly control are needed. Salivary gland and Malpighian tubule function are critical for H. irritans survivorship as they drive bloodmeal acquisition and maintain ion- and fluid homeostasis during bloodmeal processing, respectively. Experiments were conducted to test the hypothesis that pharmacological modulation of H. irritans inward rectifier potassium (Kir) channels would preclude blood feeding and induce mortality by reducing the secretory activity of the salivary gland while simultaneously inducing Malpighian tubule failure. Experimental results clearly indicate structurally diverse Kir channel modulators reduce the secretory activity of the salivary gland by up to fivefold when compared to control and the reduced saliva secretion was highly correlated to a reduction in bloodmeal acquisition in adult flies. Furthermore, adult feeding on blood treated with Kir channel modulators resulted in significant mortality. In addition to validating the Kir channels of H. irritans as putative insecticide targets, the knowledge gained from this study could be applied to develop novel therapeutic technologies targeting salivary gland or Malpighian tubule function to reduce the economic burden of horn fly ectoparasitism on cattle health and production.
Definability in first-order theories of graph orderings ⋆
Authors: Ramanujam R , Thinniyam Ramanathan S 
Published: February 2020

AbstractWe study definability in the first-order theory of graph order: i.e. the set of all isomorphism types of simple finite graphs ordered by either the minor, subgraph or induced subgraph relation. Natural graph families like cycles and trees are definable in these orders, as also notions like connectivity, maximum degree, etc. This machinery allows us to show mutual interpretability with arithmetic for all orders. We discuss implications for formalizing statements of graph theory in such theories of order. 1
Signatures of the core-powered mass-loss mechanism in the exoplanet population: dependence on stellar properties and observational predictions
Authors: Gupta Akash , Schlichting Hilke E 
Published: February 2020

ABSTRACT
Recent studies have shown that atmospheric mass-loss powered by the cooling luminosity of a planet’s core can explain the observed radius valley separating super-Earths and sub-Neptunes, even without photoevaporation. In this work, we investigate the dependence of this core-powered mass-loss mechanism on stellar mass (M*), metallicity (Z*), and age (τ*). Without making any changes to the underlying planet population, we find that the core-powered mass-loss model yields a shift in the radius valley to larger planet sizes around more massive stars with a slope given by dlog Rp/dlog M* ≃ 0.35, in agreement with observations. To first order, this slope is driven by the dependence of core-powered mass-loss on the bolometric luminosity of the host star and is given by dlog Rp/dlog M* ≃ (3α − 2)/36 ≃ 0.33, where (L*/L⊙) = (M*/M⊙)α is the stellar mass–luminosity relation and α ≃ 4.6 for the CKS data set. We therefore find, in contrast to photoevaporation models, no evidence for a linear correlation between planet and stellar mass, but cannot rule it out either. In addition, we show that the location of the radius valley is, to first order, independent of stellar age and metallicity. Since core-powered mass-loss proceeds over Gyr time-scales, the abundance of super-Earths relative to sub-Neptunes increases with age but decreases with stellar metallicity. Finally, due to the dependence of the envelope’s cooling time-scale on metallicity, we find that the radii of sub-Neptunes increase with metallicity and decrease with age with slopes given by dlog Rp/dlog Z* ≃ 0.1 and dlog Rp/dlog τ* ≃ −0.1, respectively. We conclude with a series of observational tests that can differentiate between core-powered mass-loss and photoevaporation models.
On the comparison of AGN with GRMHD simulations: I. Sgr A*
Authors: Anantua Richard , Ressler Sean , Quataert Eliot 
Published: February 2020

ABSTRACT
We present models of Galactic Centre emission in the vicinity of Sagittarius A* that use parametrizations of the electron temperature or energy density. These models include those inspired by two-temperature general relativistic magnetohydrodynamic (GRMHD) simulations as well as jet-motivated prescriptions generalizing equipartition of particle and magnetic energies. From these models, we calculate spectra and images and classify them according to their distinct observational features. Some models produce morphological and spectral features, e.g. image sizes, the sub-mm bump, and low-frequency spectral slope compatible with observations. Models with spectra consistent with observations produce the most compact images, with the most prominent, asymmetric photon rings. Limb-brightened outflows are also visible in many models. Of all the models we consider, that which represents the current data the best is one in which electrons are relativistically hot when magnetic pressure is larger than the thermal pressure, but cold (i.e. negligibly contributing to the emission) otherwise. This work is part of a series also applying the ‘observing’ simulations methodology to near-horizon regions of supermassive black holes in M87 and 3C 279.
Point spread function modelling for wide-field small-aperture telescopes with a denoising autoencoder
Authors: Jia Peng , Li Xiyu , Li Zhengyang , Wang Weinan , Cai Dongmei 
Published: February 2020

ABSTRACTThe point spread function reflects the state of an optical telescope and it is important for the design of data post-processing methods. For wide-field small-aperture telescopes, the point spread function is hard to model because it is affected by many different effects and has strong temporal and spatial variations. In this paper, we propose the use of a denoising autoencoder, a type of deep neural network, to model the point spread function of wide-field small-aperture telescopes. The denoising autoencoder is a point spread function modelling method, based on pure data, which uses calibration data from real observations or numerical simulated results as point spread function templates. According to real observation conditions, different levels of random noise or aberrations are added to point spread function templates, making them realizations of the point spread function (i.e. simulated star images). Then we train the denoising autoencoder with realizations and templates of the point spread function. After training, the denoising autoencoder learns the manifold space of the point spread function and it can map any star images obtained by wide-field small-aperture telescopes directly to its point spread function. This could be used to design data post-processing or optical system alignment methods.
Ages and kinematics of chemically selected, accreted Milky Way halo stars
Authors: Das Payel , Hawkins Keith , Jofré Paula 
Published: February 2020

ABSTRACT
We exploit the [Mg/Mn]-[Al/Fe] chemical abundance plane to help identify nearby halo stars in the 14th data release from the APOGEE survey that have been accreted on to the Milky Way. Applying a Gaussian Mixture Model, we find a ‘blob’ of 856 likely accreted stars, with a low disc contamination rate of ∼7 per cent. Cross-matching the sample with the second data release from Gaia gives us access to parallaxes and apparent magnitudes, which place constraints on distances and intrinsic luminosities. Using a Bayesian isochrone pipeline, this enables us to estimate new ages for the accreted stars, with typical uncertainties of ∼20 per cent. This does not account for systematic uncertainties. Our new catalogue is further supplemented with estimates of orbital parameters. The blob stars span [Fe/H] between −2.5 to −0.5, and [Mg/Fe] between −0.1 to 0.5. They constitute ∼30 per cent of the metal-poor ([Fe/H] &lt; −0.8) halo at [Fe/H] ∼ −1.4. Our new ages mainly range between 8 to 13 Gyr, with the oldest stars the metal-poorest, and with the highest [Mg/Fe] abundance. If the blob stars are assumed to belong to a single progenitor, the ages imply that star formation lasted 5 Gyr after which the system merged with our Milky Way around 8 Gyr ago. Dynamical arguments suggest that such a single progenitor would have had a total mass of $\sim 10^{11}\, \mathrm{M}_{\odot }$, similar to that found by other authors using chemical evolution models and simulations.