bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optogenetic Activation of β-Endorphin Terminals in the Medial Preoptic Nucleus Regulates Female Sexual Receptivity
Authors: Johnson Caroline , Hong Weizhe , Micevych Paul 
Published: January 2020

AbstractEstrogen and progesterone (P4) act in neural circuits to elicit lordosis, the stereotypical female sexual receptivity behavior. Estradiol acts through membrane receptors to rapidly activate a limbic-hypothalamic circuit consisting of the arcuate (ARH), medial preoptic (MPN), and ventromedial (VMH) nuclei of the hypothalamus. This initial activation results in a transient but necessary inhibition of lordosis, which appears to be a result of the release of β-endorphin (β-End) from proopiomelanocortin (POMC) terminals onto cells containing the µ-opioid receptor (MOR) in the MPN. To functionally examine the role of the MOR in the hypothalamic lordosis circuit, we transfected a channelrhodopsin (ChR2) adeno-associated virus into POMC cell bodies in the ARH and photostimulated POMC/β-End axon terminals in the MPN in sexually receptive female Pomc-cre mice. Following estrogen and P4 priming, sexual receptivity was assessed by measuring the lordosis quotient (LQ). Following an initial trial for sexual receptivity, mice were photostimulated during behavioral testing, and brains were processed for MOR immunohistochemistry (IHC). Photostimulation decreased the LQ only in ChR2-expressing Pomc-cre mice. Furthermore, photostimulation of ChR2 in POMC/β-End axon terminals in the MPN resulted in the internalization of MOR, indicating activation of the receptor. Our results suggest that the activation of the MOR in the MPN is sufficient to attenuate lordosis behavior in a hormone-primed, sexually receptive female mouse. These data support a central role of MOR in female sexual behavior, and provide further insight into the hypothalamus control of sexual receptivity.
Hsc70 Ameliorates the Vesicle Recycling Defects Caused by Excess α-Synuclein at Synapses
Authors: Banks Susan M. L. , Medeiros Audrey T. , McQuillan Molly , Busch David J. , Ibarraran-Viniegra Ana Sofia , Sousa Rui , Lafer Eileen M. , Morgan Jennifer R. 
Published: January 2020

Abstractα-Synuclein overexpression and aggregation are linked to Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and several other neurodegenerative disorders. In addition to effects in the cell body, α-synuclein accumulation occurs at presynapses where the protein is normally localized. While it is generally agreed that excess α-synuclein impairs synaptic vesicle trafficking, the underlying mechanisms are unknown. We show here that acute introduction of excess human α-synuclein at a classic vertebrate synapse, the lamprey reticulospinal (RS) synapse, selectively impaired the uncoating of clathrin-coated vesicles (CCVs) during synaptic vesicle recycling, leading to an increase in endocytic intermediates and a severe depletion of synaptic vesicles. Furthermore, human α-synuclein and lamprey γ-synuclein both interactin vitrowith Hsc70, the chaperone protein that uncoats CCVs at synapses. After introducing excess α-synuclein, Hsc70 availability was reduced at stimulated synapses, suggesting Hsc70 sequestration as a possible mechanism underlying the synaptic vesicle trafficking defects. In support of this hypothesis, increasing the levels of exogenous Hsc70 along with α-synuclein ameliorated the CCV uncoating and vesicle recycling defects. These experiments identify a reduction in Hsc70 availability at synapses, and consequently its function, as the mechanism by which α-synuclein induces synaptic vesicle recycling defects. To our knowledge, this is the first report of a viable chaperone-based strategy for reversing the synaptic vesicle trafficking defects associated with excess α-synuclein, which may be of value for improving synaptic function in PD and other synuclein-linked diseases.
Tenure Conflicts Resolution Of Colol Custom Community In Ruteng Recreation Park, Nusa Tenggara Timur
Authors: Rofii Kriswoyo - 
Published: January 2020

AbstractDetermination of the Ruteng Recreation Nature Park had caused conflicts over tenure for Colol custom community have been in and around the area since before the establishment. Conflict was due forÂ access to agricultural land use and timber had closed by the management. The conflict resolution involves three elements, namely the government, customs and religion which are called the three pillars. This study aims to understand the stages of the tenure conflict, relevant stakeholders and the conflict resolution. The study was conducted Colol village in April to May 2016. Acquisition of data using observation, in-depth interviews with a purposive and snowball and secondary data. Analysis of data using conflict tree analysis, stakeholders and mapping conflicts. The results showed that the cause of the conflict is the difference in value systems that implicates disagreement land status and boundaries as well as the uncertainty of access due to rights issues and access. Conflict resolution is required is to build trust between the parties, improve communication to reduce the differences in perception, increased involvement of indigenous peoples in the management of Ruteng Recreation Park, reconstruction of recreation park boundaries involving the parties, especially the major stakeholders and optimizing the coordination and communication between the parties.Colol Custom Community determine their traditional territory option to pull out of the Ruteng Recreation Park.Â
From Popular to Partisan Public Sphere: The Political Change of the Coffee Shops in Kepulauan Riau
Authors: Samnuzulsari Tri , Edison Edison , Yudiatmaja Wayu Eko 
Published: January 2020

The primary aim of this study is to investigate the political transformation of the coffee shops in Kepulauan Riau before local leaders election. It is drived by the empirical facts that many coffee shops have transformed to be supporter of one of the candidates of local head government. By using grounded theory and thematic analysis, this study answers the critical questions of why the coffee shops change and what the factors affecting the transformation. A series of interview were conducted on a dozen of informants, consisted of political parties, campaign and success teams of the candidates, Local General Elections Commission (KPUD), Local Election Supervisory Agency (Bawaslu), the owners and the visitors of the coffee shop. Evidence of this study points out that the transformation of the coffee shops is the consequences of both political system and political structure in Indonesia. The empirical findings of this study are not only worthwile to the study of public sphere in the context of Indonesian local political setting but also to the practicioners in designing the truthful and fair local general election.Â Â
CGSEA: A Flexible Tool for Evaluating the Associations of Chemicals with Complex Diseases
Authors: Cheng Shiqiang , Ma Mei , Zhang Lu , Liu Li , Cheng Bolun , Qi Xin , Liang Chujun , Li Ping , Kafle Om Prakash , Wen Yan , Zhang Feng 
Published: January 2020

Abstract
The etiology of many human complex diseases or traits involves interactions between chemicals and genes that regulate important physiological processes. It has been well documented that chemicals can contribute to disease development through affecting gene expression in vivo. In this study, we developed a flexible tool CGSEA for scanning the candidate chemicals associated with complex diseases or traits. CGSEA only need genome-wide summary level data, such as transcriptome-wide association studies (TWAS) and mRNA expression profiles. CGSEA was applied to the GWAS summaries of attention deficiency/hyperactive disorder, (ADHD), autism spectrum disorder (ASD) and cervical cancer. CGSEA identified several significant chemicals, which have been demonstrated to be involved in the development or treatment of ADHD, ASD and cervical cancer. The CGSEA program and user manual are available at https://github.com/ChengSQXJTU/CGSEA.
A impertinência de uma ética sartriana
Authors: Norberto Marcelo da Silva 
Published: January 2020

O artigo analisa os pressupostos para a questão da existência de uma ética em Jean-Paul Sartre. Para tanto, discute a relação da forma ensaística com o pensamento de Sartre, especialmente em L’être et le néante se debate a pertinência da noção de autenticidade, questionando-a a partir da crítica da noção de origem. A partir desses dois temas, a pergunta sobre uma ética sartriana é posta sob duas dimensões irredutíveis: impossibilidade de se efetivar enquanto tal e, ao mesmo tempo, exigência da questão ética em qualquer reflexão sobre a filosofia de Sartre. Por fim, o problema moral, com seus paradoxos e suas exigências, ainda se mostra como a privilegiada alternativa de uma contemporaneidade para o existencialismo
É a modularidade massiva um programa de pesquisa empiricamente progressivo?
Authors: Meurer César Fernando 
Published: January 2020

A modularidade massiva pode ser descrita como um programa de pesquisa, nos termos da filosofia da ciência de Lakatos. Cumpre, para tanto, identificar o núcleo, mostrar evidências de que ele é assumido como infalsificável (heurística negativa) e examinar estratégias de articulação e sofisticação do cinto de proteção (heurística positiva). No presente trabalho, faço isso com o intuito de responder à pergunta lançada no título. Em atenção a três desenvolvimentos recentes, cujas predições encontraram corroboração empírica, sou levado a inferir que esse programa é, de fato, empiricamente progressivo.
O princípio da proliferação contra o argumento da eliminação. o caso das ciências sociais
Authors: Oliva Alberto 
Published: January 2020

Com o objetivo de criticar a defesa do Princípio da Proliferação feita por Feyerabend, avaliaremos em que medida as ciências sociais se beneficiam do fato de abrigarem uma considerável diversidade de teorias e metodologias. A despeito de ser uma realidade nas disciplinas sociais, a proliferação nunca é vista como capaz de incrementar a testagemde uma teoria contrastando-a com alternativas. Os cientistas sociais descreem que existam falsificadores potenciais de uma teoria que só teorias diferentes se revelam aptas a localizar. Tendo de conviver com a diversidade explicativa, as ciências sociais contrariam a tese feyerabendiana de que, em virtude de cada teoria ter acesso apenasa determinados fatos, a desconsideração de alteridades deixa na penumbra fatos localizados por elas. A multiplicação de ópticas tem sido combatida recorrendo-se ao argumento da eliminação por meio do qual as teorias sociais já formuladas são escrutinadas com o objetivo de se demonstrar suas falhas e apontar uma alternativa como a única aceitável por ser a sobrevivente aos crivos empíricos. Apontaremos as razões pelas quais se tem recorrido ao argumento da eliminação contra a duplicação e a proliferação de teorias nas disciplinas sociais. A proliferação carece das vantagens epistêmicas que lhe atribui Feyerabend tendo em vista que as teorias sociais não testam umas às outras. Mesmo que possível, a testagem recíproca revela-se inútil porque se há fatos só localizáveis por uma teoria não se prestam a aferir outras teorias.
From exploitation to conservation: a historical analysis of zoos and their functions in human societies
Authors: Sampaio Marilian Boachá , Schiel Nicola , Souto Antonio da Silva 
Published: January 2020

Currently there are many interfaces that allow the relationship between humans and animals, including zoos. Throughout history, the change in zoo structure has accompanied the social and cultural changes of human society. Nevertheless, despite the remarkable progress since early zoos were organized, there is still a great need for improvements of zoos around the world. A critical look at the relationship between humans and animals that led to the establishment of zoos was the aim of this study. Zoos currently follow some precepts (entertainment, education, research and conservation), however has not been enough to bind changes in zoos that still lack in accomplishing these pillars. Such lacks create a scenario for discussions between those who believe in the potential of conservation projects developed by zoos and those who find hostile and inadequate to animal life. It can be suggested that the bedrocks were the result of how human beings have perceived animals over time, since perception interferes with the way people deal with what surrounds them. In this way, the merely utilitarian vision of prehistoric times came from the perception that people had about animals at that time. Understanding the evolution of people’s perception of animals and how this perception has influenced the configuration of zoos can tell us the directions they can take from now on. We believe that the next step is to turn our attention to the visitors, not only to meet their leisure expectations, but for them to become allies in the fight for biodiversity conservatio.
Caracterización del proceso de implementación de la Política Nacional para el Control de la Tuberculosis en Costa Rica, 2012-2015
Authors: Fernández Villalobos Nathalie 
Published: January 2020

Objetivo: caracterizar el proceso de implementación de la Política Nacional para el Control de la Tuberculosis, en Costa Rica, 2012-2015. Métodos: se utilizó la estrategia política de Monitoreo y Evaluación (M&E) con la finalidad de analizar los objetivos del programa según su contexto y los indicadores obtenidos durante el período 2012-2015. Se planteó un estudio instrumental de caso para saber cuáles componentes de la política se han utilizado y así comprender el proceso de implementación. Se recolectó la información por medio de entrevistas semiestructuradas a las personas tomadoras de decisiones y al personal encargado de la implementación de la política. Resultados: Costa Rica para el año 2015 tuvo 8.13 casos reportados de tuberculosis (TB) por 100 000 habitantes. Además, cumplió con la meta del 85 % del tratamiento exitoso; no obstante, el porcentaje de curación fue del 60 % y el porcentaje de fallecimiento del 6.55 %. Conclusiones: se concluye que el país no realiza las estrategias de colaboración establecidas por la Organización Panamericana de la Salud, no existe coordinación intersectorial ni trabajo interinstitucional con las demás entidades que forman parte del Sistema de Salud y no se ha logrado involucrar a la comunidad ni a instituciones sociales.
Diagnóstico tardio do Vírus da Imunodeficiência Humana e da Síndrome da Imunodeficiência Adquirida em Idosos
Authors: Cruz Gylce Eloisa Cabreira Panitz , Cardoso Daniela Fillipa Batista , Silva Eduardo Sérgio Da , Silveira Renata Cristina Da Penha , Silva Alexandre Ernesto , Apóstolo João Luís Alves 
Published: January 2020

As pessoas idosas, diagnosticadas tardiamente, tem maior risco de desenvolver AIDS. Com a contagem de CD4 inferior a 200 células/ml3, elas apresentam em média mais chances de morrer no primeiro ano após o diagnóstico. Neste sentido, o objetivo desta revisão de escopo é mapear evidências relativas aos fatores associados e de risco do diagnóstico tardio de HIV/AIDS em pessoas idosas, mas especificamente, esta revisão quer dar resposta às seguintes questões: Quais são os fatores associados do diagnóstico tardio de HIV/AIDS em pessoas idosas? Quais são os fatores de riscos do diagnóstico tardio de HIV/AIDS em pessoas idosas? Que contexto o diagnóstico tardio de HIV/AIDS em pessoas idosas foi realizado? Esta revisão será orientada pela metodologia do Joanna Briggs Institute, que assentará na estratégia de definição dos participantes, conceito e contexto. Os resultados serão apresentados pelo resumo lógico e descritivo, apresentados, como um mapa de dados extraídos dos artigos e alinhado com o objetivo e as perguntas da revisão de escopo. Espera-se que esta revisão de escopo contribua para a análise compreensiva das práticas de cuidados à saúde das pessoas idosas.
Intervención médica invasiva comparada con la intervención conservadora en el tratamiento de varicosidades en mujeres gestantes: Evaluación rápida de la evidencia
Authors: Cardenas Sànchez Pilar , Gonzàlez Bermùdez Jennifer 
Published: January 2020

El objetivo de este estudio fue analizar la mejor evidencia científica disponible relacionada con la intervención médica conservadora comparada con la intervención más invasiva incluyendo la quirúrgica para el tratamiento de venas varicosas en miembros inferiores durante el embarazo y la prevención de la aparición posterior. Inició con Se aplicó la metodología de evaluación rápida de la evidencia. Se llevó a cabo una búsqueda de literatura en las bases de datos, sin límite de fechas. Criterios de inclusión: Gestantes con patología varicosa en miembros inferiores de cualquier edad. Los tipos de estudios analizados fueron Revisiones Sistemáticas, ECA, Meta-análisis o Guías de Práctica Clínica en inglés, portugués o español. Se utilizó la plataforma FLC 2.0 y Agree II para el análisis y la plantilla de Sackett para la interpretación de niveles de evidencia y grados de recomendación. Se recuperaron 322 artículos, se seleccionaron tres. Se obtuvo que la intervención recomendada es la terapia conservadora, solo en casos excepcionales se determinará otra intervención. El tratamiento invasivo incluyendo el quirúrgico, se reserva para casos delicados ya que los riesgos superan los beneficios. Se concluye que el tratamiento de primera línea para el tratamiento de varicosidades en gestantes son las medias de compresión. Los rutósidos y anticoagulantes orales parecen ayudar pero no es seguro de utilizar durante el embarazo.
Translation, cross-cultural adaptation and preliminary validation of instruments for Portuguese nursing educators regarding evidence based practice
Authors: Batista Cardoso Daniela Filipa , Fineout-Overholt Ellen , Gomes Pereira Rui Pedro , Ferraz Lucimare , Rodrigues Manuel , Apóstolo João 
Published: January 2020

I
The objective of this study is to translate and culturally adapt to European Portuguese “EBP Beliefs Scale for Educators” (EBPB-E), “EBP Implementation Scale for Educators” (EBPI-E) and “Organizational Culture & Readiness for School-wide Integration of Evidence-based Practice Survey ”for Educators (OCRSIEP-E); and to provide preliminary validation data. The study was carried out in two phases: translation and transcultural adaptation; and preliminary validation in nursing educators of nine nursing schools in Portugal. Pre-final versions of the instruments were considered easy to understand. But, the participants suggested including the possibility of "I don't know" response and increasing the recall period in the EBPI-E. 68 educators participated in phase II. The α for EBPB-E, EBPI-E and OCRSIEP-E was 0.88, 0.95 and 0.94 and the corrected element-total correlations between the items and the total score ranged from 0.20 to 0.75, 0.59 to 0.84 and -0.06 to 0.78, respectively. Preliminary findings showed a strong internal consistency. It is concluded that other validation studies with more robust samples are needed to prove the reliability and validity of the instruments.
AAtención humanizada del embarazo: la mirada de gestantes que acuden a una unidad hospitalaria de salud
Authors: Lafaurie Villamil María Mercedes 
Published: January 2020

Abordar la humanización de la atención al embarazo desde la mirada de gestantes usuarias de una unidad hospitalaria pública de Bogotá, a partir de sus experiencias, preocupaciones y temores y propuestas. Estudio cualitativo en el cual participaron 20 gestantes atendidas por la unidad; la información se obtuvo con apoyo de un taller; se realizó un análisis temático de la información obtenida. Los embarazos son asumidos por las gestantes como “una bendición”, a pesar de enfrentar, en ocasiones, situaciones adversas; los temores de las gestantes se centran especialmente en los dolores y complicaciones del parto y la posibilidad de morir o perder a sus hijos; se observan necesidades especiales en las gestantes adolescentes y las gestantes con alto riesgo obstétrico. También, las participantes proponen priorizar y agilizar la atención a las gestantes en los servicios, mejorar la información que reciben, garantizar el acompañamiento en el parto y fortalecer la escucha, la confianza y el buen trato hacia las usuarias. Según los hallazgos del estudio, el embarazo para el grupo de participantes es un evento positivo que, sin embargo, conlleva momentos de tensión, temores y preocupaciones, las cuales recaen, especialmente, en el devenir del parto. Dichas circunstancias pueden ser minimizadas, mediante la acción humanizada del equipo de salud, fortaleciendo su empoderamiento. Asimismo, se destacan los siguientes aspectos:: a nivel de calidad de la atención, la oportunidad e información hacia las usuarias y el acompañamiento durante el parto; a nivel relacional, responder a la demanda de calidez, escucha y confianza en el trato hacia las usuarias.
Factores asociados a la disposición hacia la donación de órganos en una muestra chilena
Authors: Neira San Martín Héctor , Navarro Saldaña Gracia , Jofré Oliden Ignacio 
Published: January 2020

El objetivo de este estudio fue identificar los factores asociados a la disposición hacia la donación de los órganos propios y los de un familiar cercano, de personas adultas de la provincia de Concepción, Chile.Para esto, se aplicó el Cuestionario sobre Conocimientos, Actitudes y Creencias hacia la donación de órganos (instrumento elaborado para esta investigación) a 244 personas, hombres y mujeres mayores de 18 años y pertenecientes a los grupos socioeconómicos bajo y medio. Se realizó un análisis de correspondencia simple encontrando relaciones entre la disposición a donar y la confianza en el proceso de donación y trasplante, el grado de discusión del tema en la familia, los conocimientos sobre la donación y con la religión profesada por los participantes. Se propone la creación de programas de educación orientado a la entrega de información y la invitación a discutir el tema en la familia. Palabras clave: donación de órganos, trasplante de órganos, conocimientos, actitudes, creencias
Contagion of the shareholder market: cases of Colombia, México, Perú, Chile and Argentina
Authors: Vera Leyton Marcos 
Published: January 2020

This document study the existence of financial crisis contagion, it defined like the transmission of the shocks between countries, which translates in increasing in the correlation anything beyond or fundamental link, taking as a source of contagion by EEUU, Brasil, and analyzing Mexico, Colombia, Peru, Chile and Argentina like “Infected” countries, for the period covered between July 3 of 2001, date of unification of the Colombia Stock Market, to July 3 of 2010. To identify crisis period, and to evoid volatility overestimation, it used the algorithm iterative cumulative sum of squares ICCS, developed by Inclan y Tiao (1994), additionally calculated the dynamic conditional correlation (DCC) Engle Model (2002). The document includes a review of several studies, concepts, and transmission (Contagion) methodologies, and it constitutes one of the few studies that includes Colombia like analysis source. So this study verifies the existence of contagion in the countries studies, except Argentina, but warns that the measure of impact that a crisis in a given country has over other countries is highly sensitive to the way we choose the time window before and after the crisis.