bluuebunny/crossref_metadata_2025_split huggingface dataset:
Farmers’ Perception of Selling Chili to the New Auction Market: A Case at Sleman Regency of Indonesia
Authors: Dewi Yuniar Mutiara , Nugroho Agus Dwi , Jamhari . 
Published: January 2021

Purpose : The aim of this study is to know the effect of economic and social factors on the farmers’ marketing decisions. Research Method : This research was conducted from January to March 2020. The respondents were 60 (sixty) farmers who were chosen by purposing sampling. The analysis models used in this research are likert and correlation analysis. Findings : The economic factor has a medium effect on farmers’ marketing decisions. Ease of farmers’ access to the auction market or to get information is the main economic variable to the farmers’ marketing decision. Price has a very high effect on the farmers’ marketing decisions. The social factor also affects the farmers’ marketing decisions but at a weak level. Research Limitation : The respondents only 60 farmers. Originality/ Value : Provides information for the new marketing institution to stay competitive and attractive to customers.
PREVALENCE OF SERIOUS BACTERIAL INFECTIONS IN CHILDREN WITH SICKLE CELL DISEASE AT KING ABDULAZIZ HOSPITAL, AL AHSA
Authors: Alsaif Manal , Robinson Joan , Abdulbaqi Moshtag , Aghbari Mustafa , Al Noaim Khalid , Alabdulqader Muneera 
Published: January 2021

Aim: The main aim was to report the prevalence and severity of serious bacterial infections (SBI) in children with sickle cell disease at King Abdulaziz Hospital, Al Ahsa, Saudi Arabia to aid in determining whether outpatient management of such cases is appropriate.
Methods: We conducted a retrospective chart review of febrile children less than 14 years of age admitted with sickle cell disease 2005 through 2015.
Results: During 320 admissions, 25 children had SBIs (8%) including pneumonia (n=11), osteomyelitis (n=8), bacteremia (n=3, all with Salmonella species) and UTI (n=3). All recovered uneventfully.
Conclusion: It appears that in the current era, less than 10% of febrile children with sickle cell disease in our center are diagnosed with a SBI. Over an 11-year period, there were no sequelae or deaths from SBI. Given these excellent outcomes, outpatient ceftriaxone should be considered for febrile well appearing children with sickle cell disease if they have no apparent source and parents are judged to be reliable.
SOCIAL AND FINANCIAL BARRIERS TO OPTIMUM TKI TREATMENT IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA- A KNOWLEDGE-ATTITUDES-PRACTICES STUDY FROM INDIA
Authors: Gupta Naveen , Mahapatra Manoranjan , Seth Tulika , Tyagi Seema , Sazawal Sudha , Saxena Renu 
Published: January 2021

Introduction: Outcomes in chronic myeloid leukemia (CML) have vastly improved after the introduction of tyrosine kinase inhibitors. However, patients in low and middle income countries face many challenges due to social and financial barriers.
Objective: This study was conducted with the aim of understanding socio-economic hindrances and knowledge-attitudes-practices of patients of chronic phase CML who are taking imatinib.
Materials and Methods: Patients of chronic phase CML, aged 15 and above, taking imatinib for 6 months or more were included in the study. A questionnaire (in Hindi language) was administered, enquiring about perceptions of nature of disease and its treatment, how imatinib was obtained, drug-taking behaviour, economic and social burden of the treatment.
Results: Four hundred patients were recruited (median age 37 years, median duration on imatinib 63 months). Patients hailed from 16 different Indian states and 29.75% patients had to travel more than 500 kilometres for their hospital visit. Scheduled visits were missed by 14.75%. One third of the patients were unaware of the lifelong duration of treatment and 41.75% were unaware of the risks of discontinuing treatment. Treatment was financed by three different means- 61.75% received imatinib free of cost via the Glivec International Patient Assistance Program (GIPAP), 14.25% had treatment costs reimbursed by their employer, and 24% bore the cost of treatment themselves. Patients felt financially burdened due to cost of drugs (self-paying patients), cost of investigations, expenditure of the commute and stay for hospital visit, and loss of working days due to hospital visits.
Conclusion: Cost of treatment, lack of widespread availability of hematology services and poor patient awareness are significant barriers to optimum treatment of CML in low and middle income countries.
SOCIOECONOMIC STATUS IS GLOBALLY A PROGNOSTIC FACTOR FOR OVERALL SURVIVAL OF MULTIPLE MYELOMA PATIENTS; SYNTHESIS OF STUDIES AND REVIEW OF THE LITERATURE
Authors: Intzes Stergios , Symeonidou Marianthi , Zagoridis Konstantinos , Pentidou Aikaterini , Emmanouil Spanoudakis 
Published: January 2021

Socioeconomic status (SES) is reflecting differences in sociodemographic factors affecting cancer survivorship. Deprived, low SES populations has a higher prevalence of multiple myeloma and worst survival, a gap that widens over time.
Methods: We performed a meta-analysis of 16 studies (registries and cohorts) reporting survival data of myeloma patients according to SES. Ten studies reported Hazzard Ratio (HR) (95 % CI) and 16 studies reported p values. We combined the HR from 10 studies and by using the Mosteller-Bush formula we performed the synthesis of p values according to the area of the globe.
Results: A combination of HR from 10 studies including 85198 myeloma patients weighted to sample size of each study and adopting the hypothesis of random effect returned a combined HR: 1,26 (1,13-1,31) in favor of high SES patients.
USA: Synthesis of p values coming from 6 studies (n=89807 pts) by using the Mosteller and Bush formula extracted a p-value of <0.0001 favoring high SES patients
Oceania: Synthesis of p values in two cohorts from Australia and New Zealand (n= 10196 pts) returned a p-value of 0,022 favoring high SES patients
Europe: The synthesis of p values from UK and Greece studies (n=18533 pts) returned a p-value of <0,0001 favoring high SES patients
Asia: Synthesis of 2 studies from Asia (n=915 pts) returned a p-value of <0,0001 favoring high SES patients
Conclusions: Across the globe and widening over decades socioeconomic status remains a gap for equality in myeloma care
SIMPLE PERIPHERAL BLOOD SMEAR FINDINGS OF COVID-19 PATIENTS PROVIDE INFORMATION ABOUT THE SEVERITY OF THE DISEASE AND THE DURATION OF HOSPITAL STAY.
Authors: Berber Ilhami , Cagasar Ozlem , Sarıcı Ahmet , Kirici Berber Nurcan , Aydogdu Ismet , Yildirim Asli , Gocukara Bag Harika Gozde , Acun Delen Leman , Ulutas Ozkan 
Published: January 2021

Backround
Data about the morphological changes of Covid-19 infection in peripheral blood smear are limited and association with clinical severity of the disease are not known yet. We aimed to examine the characteristics of the cells detected in the pathological rate and / or appearance and whether these findings are related to the clinical course by evaluating the peripheral blood smear at the time of diagnosis in Covid-19 patients.
Methods
Clinical features, laboratory data, peripheral blood smear of fifty patients diagnosed with Covid-19 by PCR was evaluated at diagnosis. Peripheral smear samples of the patients were compared with the age and sex matched 30 healthy controls. Pictures were taken from the paitients’peripheral blood smear. Patients were divided into two groups. Early and advanced stage patient groups were compared in terms of laboratory data and peripheral smear findings. The relationship between the laboratory values of all patients and the duration of hospitalization was analyzed.
Results
Pseudo pelger-huet, atypical lymphocytes, vacuole monocytes and pycnotic neutrophils rates were high in the patient group. Increased pseudo pelger-huet anomaly, psodo-pelger huet/mature lymphocyte ratio, decreased number of mature lymphocytes, and eosinophils in peripheral blood smear were observed in the advanced stage patients (p <0.05). A negative correlation was observed between the duration of hospitalization and mature lymphocyte, and monocytes with vacuoles rates (p <0.05).
Conclusion
Peripheral smear is a cheap, easily performed, and rapid test. Increased pseudo-pelger huet anomaly/mature lymphocytes rate is suggesting advanced stage disease, while high initial monocytes with vacuoles and mature lymphocyte rates at the time of diagnosis may be an indicator of shortened duration of hospitalization.
HEMATOLOGY PATIENT PROTECTION DURING THE COVID-19 PANDEMIC IN ITALY: A NATIONWIDE NURSING SURVEY
Authors: Botti Stefano , Serra Nicola , Castagnetti Fausto , Chiaretti Sabina , Mordini Nicola , Gargiulo Gianpaolo , Orlando Laura 
Published: January 2021

Background: Italy has been one of the first European countries hit by the COVID-19 pandemic, with many patients dying from severe respiratory issues, especially frail subjects. Hematology patients are generally thought to be at high risk of developing severe COVID-19-associated complications. The aim of this work was to describe the infection control measures adopted in Italian hematology settings to protect patients and healthcare professionals.
Materials and Methods: On behalf of the Nursing Campus in Hematology Group, a nationwide nursing survey was conducted. Questionnaire items included general information, infection control measures, patient and healthcare professional protection, information management, and participants opinion on key issues. Data have been analyzed by center location (Northern, Central or Southern Italy) and by patient age (adult vs pediatric).
Results: Forty-four Italian hematology centers participated, representing 52.4% of those invited. Patients underwent nasopharyngeal swabs (93.2%) generally the day before admission (43.2%), though less frequently in southern centers (p = 0.0377). Visitor restrictions were implemented in all centers: 65.9% barred all visitors, while 25.0% allowed visitors only for patients with specific conditions, especially in central Italy. Deficiency of personal protective equipment, including masks (45.5%) and gloves (22.7%), was reported, although the nurses’ opinion was that the emergency was nevertheless well managed in terms of protecting patients and professionals. Almost all healthcare institutions (97.7%) provided recommendations on emergency management. No significant differences were found between adult and pediatric centers in terms of infection prevention and control.
Discussion:. Low variability in patient protection strategies was observed, meaning that national recommendations were effective. However, some critical issues emerged regarding the management of infected healthcare professionals and their contacts.
REAL-WORLD OUTCOME IN THE PRE-CAR-T ERA OF MYELOMA PATIENTS QUALIFYING FOR CAR-T CELL THERAPY
Authors: Bacher Ulrike , Brechbühl Simon , Jeker Barbara , Pabst Thomas 
Published: January 2021

Introduction: CAR-T cell therapy is likely to be introduced starting from 2021 in patients with relapsed/refractory myeloma (r/r MM) in Europe. In order to qualify for commercial CAR-T treatment, it is assumed that r/r MM patients will have to be exposed to at least three lines of previous treatments including lenalidomide, bortezomib and anti-CD38 treatment. However, the outcome of this particular subgroup of r/r MM patients is largely unknown whereas this knowledge is crucial to estimate the possible benefit of eventual CAR-T treatment.
Methods: In this non-interventional, retrospective single-center study, we analyzed all subsequent r/r MM patients treated between 01/2016 (when anti-CD38 treatment was commercially introduced in Switzerland) and 04/2020 at the University Hospital of Bern. Patients were eligible for the study if they had received at least three lines of treatment including one proteasome inhibitor (PI), one immunomodulatory drug (IMID) and one anti-CD38 antibody, and if they were in need of subsequent treatment and effectively received further lines of treatment.
Results: Among 56 patients fulfilling the criteria of at least three lines of treatment including PI, IMID and anti-CD38 treatment, only 34 (60%) effectively received subsequent further therapy. This suggests that 40% of r/r MM patients never receive additional treatment after at least three lines of treatment including PI, IMID and anti-CD38 treatment. For patients receiving further treatment, the median number of previous lines of treatment was 4.5 (range 2-12), including autologous stem cell transplantation in 31 (91%) patients. 13 (37%) patients were penta-refractory. The most frequently used treatment options were IMID/dexamethasone treatment in 11 (32%) patients, followed by PI/dexamethasone in 10 (29%) patients. 21 (62%) patients received two or more additional lines of therapy. The median PFS was 6.6 months (range 0–36.6 months), the median TTNT was 7.5 months (range 1.4-24.5 months) and the median OS was 13.5 months, (range 0.1-38 months) for the first subsequent treatment. The overall response rate (ORR) to the first subsequent treatment was 41%, with a median duration of the response of 5 months (range 1-37 months). 12% of the patients achieved VGPR or better, with a median duration of response of 8 months (range 3-37 months).
Conclusion: Myeloma patients refractory after at least three lines of anti-CD38/PI/IMID treatment have a poor prognosis with a PFS of 6.6 months and OS of 13.5 months. These data may serve as reference to compare the potential benefit of CAR-T treatment in this group of myeloma patients when available in the near future.
ELEVATED SERUM PENTRAXIN-3 LEVELS IS POSITIVELY CORRELATED TO DISEASE SEVERITY AND COAGULOPATHY IN COVID-19 PATIENTS
Authors: Tong Ming , Xiong Ying , Zhu Chen , Xu Hong , Zheng Qing , Hu Changping , Jiang Yu , Zou Lianhong , Xiao Xiaolin , Chen Fang , Zhu Yimin 
Published: January 2021

Abstract
BACKGROUND Coronavirus disease 2019 (COVID-19) is highly contagious and deadly and is associated with coagulopathy. Pentraxin-3(PTX3) participates in innate resistance to infections and plays a role in thrombogenesis.
PURPOSE The present study aimed to investigate the role of PTX3 in coagulopathy in patients with COVID-19.
METHODS A retrospective study including thirty-nine COVID-19 patients enrolled in Hunan, China were performed. The patients were classified into the D-dimer_L (D-dimer?1mg/L) and D-dimer_H (D-dimer?1mg/L) groups basing on the plasma D-dimer levels on admission. Serum PTX3 levels were detected by enzyme-linked immunosorbent assays and compared between those two groups, and then linear regression models were applied to analyze the association between PTX3 and D-dimer.
RESULTS Our results showed that serum PTX3 levels (median values, 10.21 vs 3.36, P < 0.001), chest computerized tomography scores (median values, 10.0 vs 9.0, P < 0.05), and length of stay (16.0±4.2 vs 10.7±3.6, P = 0.001) in the D-dimer_H group were significantly higher than that in D-dimer_L group. The coefficient of determination for PTX3 was 0.651 (P < 0.001) in the D-dimer_H group.
CONCLUSION Serum level of PTX3 was positively correlated with disease severity and coagulopathy. Detection of serum PTX3 level could assist to identify severer patients on admission and may be a potential therapeutic target for coagulopathy in patients with COVID-19.
ECONOMÍA CIRCULAR: DESAFÍOS PARA UNA VISIÓN ESTRATÉGICA DE LAS EMPRESAS EXPORTADORAS
Authors: Diaz Calle Nathaly Gabriela , Menoscal Pincay Rita del Carmen , González Illezcas Mayiya Lisbeth 
Published: January 2021

La preocupación por la sostenibilidad del medio ambiente se hace cada vez fuerte en el ámbito de los negocios internacionales y las decisiones gubernamentales. La “Estrategia de Economía Circular” es un ejemplo de iniciativa legislativa por parte de la Unión Europea, que refleja pautas sobre la regulación del consumo de los recursos y las futuras relaciones con sus proveedores. Esta investigación tiene como propósito analizar la economía circular como estrategia competitiva para las empresas exportadoras, a partir de la revisión de 15 artículos científicos basados en investigaciones a empresas que han implementado la economía circular. El desarrollo de esta investigación se fundamentó bajo un enfoque cualitativo con la aplicación de los métodos analítico-sintético e histórico-lógico. Los resultados indican que las empresas están haciendo cambios en sus procesos productivos para contribuir a la disminución del uso de recursos y mejorar la gestión de residuos. Se concluye que las empresas, con ritmos diferentes, en función de sus fortalezas y capacidades, están consiguiendo desarrollar propuestas de valor para apuntalar la sostenibilidad de los recursos, logrando diferenciarse de sus competidores.
Códigos JEL: F18, L21, M16
Analisis Sosial Budaya terkait Pernikahan Usia Dini di Kepulauan Selayar
Authors: Ningsih Andi Pramesti , Suriah Suriah , Syafar Muhammad , Muis Masyitha , Sukri Sukri , Abdullah Muhammad Tahir 
Published: January 2021

ABSTRAKLatar Belakang. Pernikahan di usia dini menimbulkan dampak negatif terhadap remaja baik dalam aspek fisik, psikologis dan biologis. Pernikahan di usia dini sangat erat kaitannya dengan tradisi yang ada di lingkungan masyarakat seperti perjodohan.Tujuan. Penelitian ini bertujuan untuk mengeksplorasi sosial budaya terkait pernikahan usia dini di Pulau Selayar.Metode. Penelitian ini menggunakan metode kualitatif dengan pendekatan fenomenologi deskriptif. Informan terdiri termasuk remaja, orang tua, penyedia kesehatan, dan kepala komunitas. Data dikumpulkan menggunakan wawancara mendalam dan diskusi kelompok terarah sesuai dengan tujuan penelitian. Data dianalisis dengan menggunakan analisis domain.Hasil. Tiga domain utama yang ditemukan dalam penelitian ini terkait pernikahan usia dini adalah: (1) perjodohan merupakan faktor yang mendukung terjadinya pernikahan di usia dini (2) dukungan sosial yang diberikan masyarakat terhadap pernikahan di usia dini karena adanya tradisi perjodohan yang berlaku dalam lingkungan masyarakat (3) pengetahuan yang dimiliki masyarakat dan remaja masih kurang mengenai dampak pernikahan usia dini.Kesimpulan. Sosial budaya yang ada di masyarakat dapat digunakan sebagai salah satu pendekatan untuk menurunkan angka pernikahan di usia dini. ABSTRACTBackground. Marriage at an early age has a negative impact on adolescents in physical, psychological, and biological aspects. Marriage at an early age is closely related to traditions in society such as arranged marriage.Objective. This study aimed to to explore the socio-culture related to early marriage on Selayar Island.Method. This study used a qualitative method with a descriptive phenomenology approach. Informants include youth, parents, health providers, and community heads. Data were collected using in-depth interviews and focus group discussions following the research objectives. Data were analyzed using domain analysis.Results. Three main domains found in this study related to early marriage are: (1) arranged marriage is a factor that supports early marriage (2) social support from the community supporting marriage at an early age because of the prevailing arranged marriage tradition in the society (3) the knowledge possessed by the community and adolescents is still lacking about the impact of early marriageConclusion: Social culture in the community can be an approach to reducing early marriage.
Hubungan antara Pengetahuan dan Dukungan Tenaga Kesehatan dengan Perilaku Pemeriksaan Payudara Sendiri (SADARI) pada Wanita Pasangan Usia Subur (PUS)
Authors: Sari Puspita , Sayuti Solihin , Ridwan M. , Rekiaddin La Ode , Anisa Anisa 
Published: January 2021

ABSTRAKLatar Belakang. Data WHO tahun 2018 menunjukkan kasus kanker yang paling banyak terjadi di Indonesia adalah kasus kanker payudara, yakni 58.256 kasus dari total 348.809 kasus kanker. Kanker payudara sebagai penyakit yang berisiko diderita perempuan. Perlu dilakukan upaya deteksi dini dengan SADARI.Tujuan. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan dan dukungan tenaga kesehatan dengan perilaku pemeriksaan payudara sendiri (SADARI) pada wanita PUS di Kelurahan Bram Itam Kiri Kecamatan Bram Itam Kabupaten Tanjung Jabung Barat.Metode.Penelitian ini merupakan penelitian kuantitatif dengan desain cross-sectional. Penelitian ini melibatkan 93 responden yang dipilih dengan teknik Proporsionate Stratified Random Sampling untuk diwawancarai. Analisis data menggunakan chi-square.Hasil. Sebanyak 34,4% responden memiliki perilaku SADARI tidak baik. Ada hubungan bermakna antara pengetahuan dengan perilaku SADARI. Dukungan petugas kesehatan tidak memiliki hubungan yang bermakna dengan perilaku SADARI.Kesimpulan. Pemahaman responden tentang SADARI masih rendah dan ada hubungan pengetahuan dengan perilaku pemeriksan payudara sendiri (SADARI). ABSTRACTBackground. According to WHO in 2018, most cancer cases in Indonesia are breast cancer cases, with 58,256 cases out of a total of 348,809 cancer cases. Breast cancer is a disease that is at risk for women. Early detection efforts with BSE should be initiated.Objective. This study aims to determine the relationship between knowledge and support of health workers with breast self-examination behavior (BSE) on women with PUS in Bram Itam Kiri Village, Bram Itam District, Tanjung Jabung Barat Regency.Method. This research was a quantitative study with a cross-sectional design. This study involved 93 respondents who were selected using a proportional stratified random sampling technique to be interviewed. Data analysis using chi-square.Results. As many as 34.4% of respondents had bad BSE behavior. There is a significant relationship between knowledge and BSE behavior. Support from health workers did not have a significant relationship with BSE behavior.Conclusion. Respondents' understanding of BSE is still low and there is a relationship between knowledge and breast self-examination behavior (BSE).