bluuebunny/crossref_metadata_2025_split huggingface dataset:
Looking Forward Looking Back: Customary International Law, Human Rights and Indigenous Peoples
Authors: Esterling Shea 
Published: November 2020

Abstract
Two of the most laudable achievements of human rights are the 1948 Universal Declaration of Human Rights (udhr) and the 2007 United Nations Declaration on the Rights of Indigenous Peoples (undrip). Aside from advancing human rights, both are examples of soft law. For the undrip, this soft law status has generated significant controversy which is evocative of the earlier debate surrounding the legal status of the udhr. Yet unexamined, this article analyses this contemporary controversy surrounding the undrip in light of the historical debate surrounding the legal status of the udhr. Fleshing out points of convergence and divergence, these debates unearth narratives which shed light on the claims and advocacy strategies of Indigenous Peoples and the role of customary international law within human rights. Ultimately, it reveals that these narratives do little to secure the enforcement of indigenous rights.
Attribution of Extreme Precipitation with Updated Observations and CMIP6 Simulations
Authors: Dong Siyan , Sun Ying , Li Chao , Zhang Xuebin , Min Seung-Ki , Kim Yeon-Hee 
Published: November 2020

AbstractWhile the IPCC Fifth Assessment Working Group I report assessed observed changes in extreme precipitation on the basis of both absolute and percentile-based extreme indices, human influence on extreme precipitation has rarely been evaluated on the basis of percentile-based extreme indices. Here we conduct a formal detection and attribution analysis on changes in four percentile-based precipitation extreme indices. The indices include annual precipitation totals from days with precipitation exceeding the 99th and 95th percentiles of wet-day precipitation in 1961–90 (R99p and R95p) and their contributions to annual total precipitation (R99pTOT and R95pTOT). We compare these indices from a set of newly compiled observations during 1951–2014 with simulations from models participating in phase 6 of the Coupled Model Intercomparison Project (CMIP6). We show that most land areas with observations experienced increases in these extreme indices with global warming during the historical period 1951–2014. The new CMIP6 models are able to reproduce these overall increases, although with considerable over- or underestimations in some regions. An optimal fingerprinting analysis reveals detectable anthropogenic signals in the observations of these indices averaged over the globe and over most continents. Furthermore, signals of greenhouse gases can be separately detected, taking other forcing into account, over the globe and over Asia in these indices except for R95p. In contrast, signals of anthropogenic aerosols and natural forcings cannot be detected in any of these indices at either global or continental scales.
Impact of Sea Ice Reduction in the Barents and Kara Seas on the Variation of the East Asian Trough in Late Winter
Authors: Xu Mian , Tian Wenshou , Zhang Jiankai , Wang Tao , Qie Kai 
Published: November 2020

AbstractUsing the European Centre for Medium-Range Weather Forecasts (ECMWF) interim reanalysis (ERA-Interim) dataset and the Specified Chemistry Whole Atmosphere Community Climate Model (WACCM-SC), the impacts of sea ice reduction in the Barents–Kara Seas (BKS) on the East Asian trough (EAT) in late winter are investigated. Results from both reanalysis data and simulations show that the BKS sea ice reduction leads to a deepened EAT in late winter, especially in February, while the EAT axis tilt is not sensitive to the BKS sea ice reduction. Further analysis shows that the BKS sea ice reduction influences the EAT through the tropospheric and stratospheric pathways. For the tropospheric pathway, the results from a linearized barotropic model and Rossby wave ray tracing model reveal that long Rossby wave trains stimulated by the BKS sea ice loss propagate downstream to the North Pacific, strengthening the EAT. For the stratospheric pathway, the upward planetary waves enhanced by the BKS sea ice reduction shift the subpolar westerlies near the tropopause southward. With the critical lines displaced equatorward, the poleward transient eddies break at lower latitudes, shifting the eddy momentum deposit throughout the troposphere equatorward. Tropospheric westerlies maintained by eddy momentum deposit are also shifted southward, inducing the cyclonic anomalies over the North Pacific and deepening the EAT in late winter. Nudging experiments show that the tropospheric pathway only contributes to around 29.7% of the deepening of the EAT in February induced by the BKS sea ice loss, while the remaining 70.3% is caused by stratosphere–troposphere coupling.
Diagnosing the Scale- and Space-Dependent Horizontal Eddy Diffusivity at the Global Surface Ocean
Authors: Nummelin Aleksi , Busecke Julius J. M. , Haine Thomas W. N. , Abernathey Ryan P. 
Published: November 2020

AbstractOceanic tracers are transported by oceanic motions of all scales, but only the large-scale motions are resolved by the present-day Earth system models. In these models, the unresolved lateral sub-gridscale tracer transport is generally parameterized through diffusive closures with a scale-independent diffusion coefficient. However, evidence from observations and theory suggests that diffusivity varies spatially and is length-scale dependent. Here we provide new scale-dependent quantification of the global surface diffusivities. To this end we use a recently developed statistical inversion method, MicroInverse, to diagnose horizontal surface diffusivities from observed sea surface temperature and idealized model simulation. We compare the results to theoretical estimates of mixing by the large-scale shear and by the sub-gridscale velocity fluctuations. The diagnosed diffusivity magnitude peaks in the tropics and western boundary currents with minima in the subtropical gyres (~3000 and ~100 m2 s−1) at ~40-km scale, respectively. Focusing on the 40–200-km length scale range, we find that the diffusivity magnitude scales with the length scale to a power n that is between 1.22 and 1.54 (90% confidence) in the tropics and also peaks at values above 1 in the boundary currents. In the midlatitudes we find that 0.58 < n < 0.87 (90% confidence). Comparison to the theory suggests that in regions with n > 1 the horizontal mixing is dominated by large-scale shear, whereas in regions where n < 1 the horizontal mixing is due to processes that are small compared to the 40–200-km length scale range considered in this study.
Identification of the Risk Factors of Postoperative Pulmonary Complications in Elderly Patients Undergoing Elective Colorectal Surgery
Authors: Chai Jun , Sang Aming , Tan Meiyue , Long Bo , Chen Lina 
Published: November 2020

Objective This study was to identify the perioperative related risk factors of postoperative pulmonary complications (PPCs) in elderly patients undergoing elective colorectal surgery, which will provide new insight for better prevention and intervention of PPCs in elderly patients. Methods A retrospective study involving 445 patients (age ≥65), who registered in Shengjing Hospital affiliated to China Medical University for elective colorectal surgery from October 2014 to March 2017, was conducted. Clinical data, including demographic information, medical history, preoperative examination, and surgery-related factors, were analyzed and compared between the patient group with PPCs and the group without PPCs. t-test or χ2 test was performed for statistical analysis between the 2 groups. Binary logistic regression analysis was further employed to identify the potential independent risk factors of PPCs. Results Among the 445 patients enrolled in the study, 49 (11%) had PPCs, while 396 (89%) did not. The main risk factors of PPC occurrence in the elderly patients undergoing elective colorectal surgery included older age (age ≥75 years), ASA >II, hypertension, myocardial ischemia, basic pulmonary diseases, laparotomy, blood transfusion, preoperative hemoglobin <100 g/L, and albumin <35 g/L. Laparotomy (compared with laparoscope) and ASA >II were independent risk factors for the increased incidence of PPCs. Conclusion More attention should be paid to patients with older age and ASA >II in elective colorectal surgery. Choice of laparoscopic operation, proper treatment of hypertension, myocardial ischemia, basic pulmonary diseases, and correction of anemia and nutritional status can effectively reduce the incidence of PPCs. An adequate and comprehensive evaluation of the potential risk factors related to PPCs is required before surgery.
Video-assisted thoracoscopic pneumonectomy for destroyed lung
Authors: Waguaf Sara , Boubia Souheil , Idelhaj Najat , Fatene Abdellah , Ridai Mohamed 
Published: November 2020

Aim Destroyed lung refers to destruction of a large portion of a lung induced by chronic or recurrent lung infections. The aim of this single-center retrospective review was to evaluate patients with a diagnosis of destroyed lung undergoing pneumonectomy via video-assisted thoracoscopic surgery, in terms of surgical technique, postoperative morbidity and mortality, and long-term outcomes. Methods Data of 15 patients who underwent video-assisted thoracoscopic pneumonectomy for destroyed lung during a 4-year period were analyzed retrospectively. There were 9 (60%) males and 6 (40%) females with a median age of 33.87 years (range 8–52 years). Bronchiectasis ( n = 7), tuberculosis ( n = 5), and fungal infection ( n = 3) were the main etiologies. Hemoptysis was the most common presenting symptom ( n = 8, 53.3%). Destroyed lung was detected on the left side in 13 (86.7%) patients and on the right side in 2 (13.3%). Seven patients showed narrowing or thickening of the main bronchus. Results Video-assisted thoracoscopic pneumonectomy was attempted in all patients but 5 (33.3%) were converted to a thoracotomy. The mean operative time was 273.8 min. The postoperative morbidity rate was 13.3%. The mortality rate was 6.67%. The median length of hospital stay was 3.5 days. The mean follow-up period was 23.7 months. Significant improvement was observed in inflammatory symptoms and quality of life in all patients. The overall 1-year survival was 93.3%. Conclusion Video-assisted thoracoscopic pneumonectomy for destroyed lung is a safe and feasible option in selected patients, which can be used as an alternative to thoracotomy.
Exploring the Cost Effectiveness of Shared Decision Making for Choosing between Disease-Modifying Drugs for Relapsing-Remitting Multiple Sclerosis in the Netherlands: A State Transition Model
Authors: Kremer Ingrid E. H. , Hiligsmann Mickael , Carlson Josh , Zimmermann Marita , Jongen Peter J. , Evers Silvia M. A. A. , Petersohn Svenja , Pouwels Xavier G. L. V. , Bansback Nick 
Published: November 2020

Background Up to 31% of patients with relapsing-remitting multiple sclerosis (RRMS) discontinue treatment with disease-modifying drug (DMD) within the first year, and of the patients who do continue, about 40% are nonadherent. Shared decision making may decrease nonadherence and discontinuation rates, but evidence in the context of RRMS is limited. Shared decision making may, however, come at additional costs. This study aimed to explore the potential cost-effectiveness of shared decision making for RRMS in comparison with usual care, from a (limited) societal perspective over a lifetime. Methods An exploratory economic evaluation was conducted by adapting a previously developed state transition model that evaluates the cost-effectiveness of a range of DMDs for RRMS in comparison with the best supportive care. Three potential effects of shared decision making were explored: 1) a change in the initial DMD chosen, 2) a decrease in the patient’s discontinuation in using the DMD, and 3) an increase in adherence to the DMD. One-way and probabilistic sensitivity analyses of a scenario that combined the 3 effects were conducted. Results Each effect separately and the 3 effects combined resulted in higher quality-adjusted life years (QALYs) and costs due to the increased utilization of DMD. A decrease in discontinuation of DMDs influenced the incremental cost-effectiveness ratio (ICER) most. The combined scenario resulted in an ICER of €17,875 per QALY gained. The ICER was sensitive to changes in several parameters. Conclusion This study suggests that shared decision making for DMDs could potentially be cost-effective, especially if shared decision making would help to decrease treatment discontinuation. Our results, however, may depend on the assumed effects on treatment choice, persistence, and adherence, which are actually largely unknown.
Importance Hierarchy of Surrogate Medical Decision Making Determinants: A Q-Methodology Study in Middle Eastern and East Asian Men
Authors: Hammami Muhammad M. , Abuhdeeb Kafa , Balkhi Areej Al 
Published: November 2020

Background Factors other than patient’s preference may influence surrogate medical decision making in a culture- and viewpoint-dependent way. We explored the importance hierarchy of potential surrogate medical decision making determinants to Middle-Eastern (ME) and East-Asian (EA) men according to their norm-perception (N-viewpoint), preference as patients (P-viewpoint), and preference as surrogate decision-makers (S-viewpoint). Methods Each respondent (120 ME, 120 EA) sorted 28 items reflecting potential determinants into a fixed distribution of importance hierarchy according to the three viewpoints. Latent decision making models were explored by by-person factor analysis (Q-methodology). Results Six models were identified for each ME and EA viewpoint (total 36). Patient’s health-related, patient’s preference-related, and society’s interests-related determinants were strongly embraced in 34, 3, and zero models and strongly discounted in 2, 5, and 21 models, respectively. Patient’s religious/spiritual belief was strongly embraced in 6 EA models compared to 2 ME models and strongly discounted in 2 EA models compared to 5 ME models. Further, family-centric and surrogate’s interest-related determinants were strongly embraced in 8 EA models compared to 1 ME model. They were also strongly embraced in 5 P-viewpoint compared to 2 S-viewpoint models and strongly discounted in 4 P-viewpoint compared to 11 S-viewpoint models. Despite the overall predominance of patient’s health-related determinants and culture- and viewpoint-dependent differences, Q-methodology analysis identified relatively patient’s preference-influenced, religious/spiritual beliefs–influenced, emotion-influenced, and familism-influenced models and showed notable overlap in models. Conclusions Patient’s health was more important than other potential medical surrogate decision making determinants, including patient’s preference, for both ME and EA men and in all viewpoints. The relative importance of some determinants was culture- and viewpoint- dependent and allowed description of different albeit overlapping models.
Pediatric PROMIS Computer Adaptive Tests Are Highly Correlated With Adult PROMIS Computer Adaptive Tests in Pediatric Sports Medicine Patients
Authors: Bernstein David N. , Franovic Sreten , Smith D. Grace , Hessburg Luke , Yedulla Nikhil , Moutzouros Vasilios , Makhni Eric C. 
Published: November 2020

Background: The Patient-Reported Outcomes Measurement Information System (PROMIS) is a powerful set of patient-reported outcome measures (PROMs) that are gaining popularity throughout orthopaedic surgery. The use of both adult and pediatric PROMIS questionnaires in orthopaedic sports medicine limits the value of the PROMIS in routine sports medicine clinical care, research, and quality improvement. Because orthopaedic sports medicine surgeons see patients across a wide age range, simplifying the collection of PROMIS computer adaptive tests (CATs) to a single set of questionnaires, regardless of age, is of notable value. Purpose/Hypothesis: The purpose was to determine the strength of the correlation between the pediatric and adult PROMIS questionnaires. We hypothesized that there would be a high correlation between the adult and pediatric versions for each PROMIS domain, thereby justifying the use of only the adult version for most sports medicine providers, regardless of patient age. Study Design: Cohort study (Diagnosis); Level of evidence, 2. Methods: Between December 2018 and December 2019, all pediatric sports medicine patients presenting to a single, academic, orthopaedic sports medicine clinic were asked to participate in the present study with their parents’ consent. Patients were asked to complete a set of adult PROMIS domains (Physical Function and/or Upper Extremity, Pain Interference, and Depression) as well as a set of pediatric PROMIS domains (Mobility and/or Upper Extremity, Pain Interference, and Depressive Symptoms). Concurrent validity was assessed using Pearson correlation coefficients ( r). Ceiling and floor effects were determined. Results: A total of 188 patients met our inclusion criteria. The correlation between the adult and pediatric PROMIS Upper Extremity, Physical Function and Mobility, Pain Interference, and Depression and Depressive Symptoms forms were high-moderate ( r = 0.68; P < .01), high-moderate ( r = 0.69; P < .01), high ( r = 0.78; P < .01), and high ( r = 0.85; P < .01), respectively. Both adult and pediatric depression-related PROMIS domains demonstrated notable floor effects (adult: 38%; pediatric: 24%). The pediatric PROMIS Upper Extremity domain demonstrated a ceiling effect (20%). Conclusion: Adult PROMIS CATs may be used in an orthopaedic sports medicine clinic for both adult and pediatric patients. Our findings will help decrease the amount of resources needed for the implementation and use of PROMs for patient care, research, and quality improvement in orthopaedic sports medicine clinics.
Maternal Mental Health after a Wildfire: Effects of Social Support in the Fort McMurray Wood Buffalo Study
Authors: Verstraeten Barbara S. E. , Elgbeili Guillaume , Hyde Ashley , King Suzanne , Olson David M. 
Published: November 2020

Objective: Following disasters, perinatal women are vulnerable to developing post-traumatic stress disorder (PTSD)-like symptoms. Little is known about protective factors. We hypothesized that peritraumatic stress would predict PTSD-like symptoms in pregnant and postpartum women and would be moderated by social support and resilience. Method: Women ( n = 200) who experienced the 2016 Fort McMurray Wood Buffalo wildfire during or shortly before pregnancy completed the Peritraumatic Distress Inventory (PDI), Peritraumatic Dissociative Experiences Questionnaire, and the Impact of Event Scale-Revised for current PTSD-like symptoms. They also completed scales of social support (Social Support Questionnaire-Short Form) and resilience (Connor-Davidson Resilience Scale). Results: Greater peritraumatic distress ( r = 0.56) and dissociative experiences ( r = 0.56) correlated with more severe PTSD-like symptoms. Greater social support satisfaction was associated with less severe post-traumatic stress symptoms but only when peritraumatic distress was below average; at more severe levels of PDI, this psychosocial variable was not protective. Conclusions: Maternal PTSD-like symptoms after a wildfire depend on peritraumatic distress and dissociation. Higher social support satisfaction buffers the association with peritraumatic distress, although not when peritraumatic reactions are severe. Early psychosocial interventions may protect perinatal women from PTSD-like symptoms after a wildfire.
The Canadian Network for Mood and Anxiety Treatments (CANMAT) Task Force Recommendations for the Use of Racemic Ketamine in Adults with Major Depressive Disorder: Recommandations Du Groupe De Travail Du Réseau Canadien Pour Les Traitements De L’humeur Et De L’anxiété (Canmat) Concernant L’utilisation De La Kétamine Racémique Chez Les Adultes Souffrant De Trouble Dépressif Majeur
Authors: Swainson Jennifer , McGirr Alexander , Blier Pierre , Brietzke Elisa , Richard-Devantoy Stéphane , Ravindran Nisha , Blier Jean , Beaulieu Serge , Frey Benicio N. , Kennedy Sidney H. , McIntyre Roger S. , Milev Roumen V. , Parikh Sagar V. , Schaffer Ayal , Taylor Valerie H. , Tourjman Valérie , van Ameringen Michael , Yatham Lakshmi N. , Ravindran Arun V. , Lam Raymond W. 
Published: November 2020

Objective: Patients with major depressive disorder often have limited response to first-line and second-line medications; hence, novel pharmacological treatments are needed for treatment-resistant depression (TRD). Ketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist, has demonstrated rapid antidepressant effects in patients with TRD. The Canadian Network for Mood and Anxiety Treatments (CANMAT) convened a task force to review the evidence for efficacy and safety of racemic ketamine and to provide recommendations for its use in clinical practice. Methods: A systematic review was conducted with computerized search of electronic databases up to January 31, 2020 using combinations of search terms, inspection of bibliographies, and review of other ketamine guidelines and consensus statements. The level of evidence and lines of treatment were assigned according to CANMAT criteria. Recommendations were given in question–answer format. Results: Intravenous (IV) racemic ketamine given as a single infusion has Level 1 evidence for efficacy in adults with TRD. The evidence for multiple infusions, given as an acute series or as ongoing maintenance treatment, is limited to Level 3. Adverse events associated with ketamine infusions include behavioral (e.g., dissociative symptoms) and physiological (e.g., hypertension) events. There is only Level 3 or 4 evidence for non-IV formulations of racemic ketamine. Consensus recommendations are given for clinical administration of IV ketamine including patient selection, facility and personnel issues, monitoring, and maintaining response. Conclusions: Single-dose IV racemic ketamine is a third-line recommendation for adults with TRD. The need for repeated and maintenance ketamine infusions should be carefully assessed on a case-by-case basis with consideration of potential risks and benefits. Because of limited evidence for efficacy and risk for misuse and diversion, the use of oral and other formulations of racemic ketamine should be limited to specialists with ketamine-prescribing expertise and affiliations with tertiary or specialized centers.