bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a Prediction Model for Author Collaboration in Bioinformatics Research Using Graph Mining Techniques and Big Data Applications
Authors: Ebrahimi Fezzeh , Asemi Asefeh , Shabani Ahmad , Nezarat Amin 
Published: November 2020

Abstract
Nowadays, scientific collaboration has dramatically increased as a result of web-based technologies, advanced communication systems, and development of information and scientific databases. The present study aims to provide a predictive model for author collaborations in bioinformatics research output using graph mining techniques and big data applications. The study is an applied-developmental research adopting a mixed-method approach, i.e. a mix of quantitative and qualitative measures. The research population consisted of all bioinformatics research documents indexed in PubMed (n = 699160). The correlations of bioinformatics articles were examined in terms of weight and strength based on article sections including title, abstract, keywords, journal title, and author affiliation using graph mining techniques and big data applications. Eventually, the prediction model of author collaboration in bioinformatics research was developed using the abovementioned tools and expert-assigned weights. The calculations and data analysis were carried out using Expert Choice, Excel, Spark as well as Scala and Python programming languages in a big data server. Accordingly, the research was conducted in three phases: 1) identifying and weighting the factors contributing to authors’ similarity measurement; 2) implementing co-authorship prediction model; and 3) integrating the first and second phases (i.e. integrating the weights obtained in the previous phases). The results showed that journal title, citation, article title, author affiliation, keywords, and abstract scored 0.374, 0.374, 0.091, 0.075, 0.055, and 0.031, respectively. Moreover, the journal title achieved the highest score in the model for the co-author recommender system. As the data in bibliometric information networks is static, it was proved remarkably effective to use content-based features for similarity measures so that the recommender system can offer the best and most suitable collaboration suggestions. It is expected that the model work efficiently in other databases and provide suitable recommendations for author collaborations in other subject areas. By integrating expert opinion and systemic weights, the model can help alleviate the contemporary information overload and facilitate collaborator lookup by authors.
Butyrophilin-Like 9 Regulates Immune Infiltration and Serves as a Prognostic Marker in Lung Adenocarcinoma
Authors: Ma Weishuang , Liang Jiaming , Zhang Siyuan , Ningdong Hu , Chen Zisheng , Tian Dongbo 
Published: November 2020

Abstract
Background: Butyrophilin (BTN) and butyrophilin-like (BTLN) belong to immunoglobulin superfamily, and also pertain the B7 co-stimulatory molecules family, which has multiple roles in immune modulation. Whether the BTNL9 expression in lung adenocarcinoma (LUAD) correlates with outcome has not been evaluated.Methods: Oncomine and GEPIA were used to analyze the BTNL9, while its mRNA expression in LUAD and corresponding adjacent tissues was investigated using TIMER. The clinical prognosis of BTNL9 was assessed in the GEPIA, Kaplan-Meier plotter, and OncoLnc. Besides, the correlation between BTNL9 and tumor-infiltrating immune cells (TILs) was analyzed using TIMER and GEPIA. The correlation between BTNL9 expression and drug response was analyzed using CARE.Results: BNL9 expression was significantly low in LUAD. Low BTNL9 expression was associated with poor OS, and its expression was found to be regulated by both epigenetic regulation and post-transcriptional modification. BTNL9 expression was significant positively correlated with ImmuneScore and ESTIMATEScore. Moreover, BTNL9 expression was positively correlated with infiltrating levels of B cells, CD4+T, and macrophages, but Kaplan-Meier analysis showed that BTNL9 expression in B cells and DCs was significantly associated with OS. Furthermore, BTNL9 expression has significant positive CARE scores. Conclusions: Low BTNL9 expression can prevent the infiltration of naïve B cells and DCs in the tumor microenvironment and worsen the outcome in LUAD patients. Besides, these findings also suggest the potential role of BTNL9 as a prognostic biomarker and a new immuno-target.
Do health policies address the availability, accessibility, acceptability, and quality of human resources for health?: Analysis of three decades of National Health Policy of India
Authors: Dubey Sweta , Vasa Jeel , Zadey Siddhesh 
Published: November 2020

Abstract
Background: Human Resources for Health (HRH) are crucial to improve health services coverage and population health outcomes. The World Health Organisation (WHO) promotes four dimensions - availability, accessibility, acceptability, and quality (AAAQ) for HRH strengthening. Integrating AAAQ dimensions in policymaking is essential to reduce the critical shortage of HRH in India. Methods: We created a multilevel framework to evaluate the incorporation of AAAQ dimensions along with strategies and actions that can improve them in HRH-related policies. HRH-related recommendations of all versions of the National Health Policy of India (NHPI) were classified according to targeted dimensions and cadres. We evaluated the extent to which NHPIs incorporated AAAQ dimensions over three decades. Furthermore, dimension-wise normalized indices were formulated to calculate HRH deficits for pre-NHPI years to assess situational deficiencies. Finally, we evaluated whether or not the HRH recommendations of NHPIs addressed the deficient cadres and dimensions for the corresponding year. Results: We observed that HRH availability and quality were focused more in NHPI compared to accessibility and acceptability. Doctors were prioritized over auxiliary nurses-midwives and health assistants. AAAQ indices showed deficits in all dimensions in almost all cadres over the years. The cadres focused by NHPI recommendations did not completely correspond to the deficient cadres. Conclusion: The framework and indices based method can help identify the gaps between targeted and needed dimensions and cadres for effective HRH strengthening in countries. At the global level, the application of framework and indices will allow a comparison of strengths and weaknesses of HRH-related policies of various nations.
Stateless Iraqi Kurdish children and adolescents’ mental health: A Scoping Review
Authors: Chen En Chi 
Published: November 2020

Abstract
Kurdistan is one of the largest stateless nations in the world. Due to its geographical location, straddled between four major nation-states often in conflict with one another, Kurds face a disproportional level of conflict. Research has shown that there are significant mental health consequences as a result of living in conflict zones. It is suspected that the experience of statelessness in Kurdistan differs from the experience of individuals in neighbouring states, regardless of similar conflicts (Iraq, Iran, Syria, and Turkey). This could be due to the compounding effects of a sense of ‘not belonging’, as well as having barriers to accessing mental healthcare as a stateless individual. The current paper seeks to highlight the present literature on the understanding of conflict-related mental health consequences specifically affecting Iraqi Kurdish children and adolescents and to outline gaps in knowledge through a scoping review.
Fungi Outcompete Bacteria for Straw and Soil Organic Matter Mineralization
Authors: Xiao Dan , He Xunyang , Wang Guihong , Xu Xuechi , Hu Yajun , Chen Xiangbi , Zhang Wei , Su Yirong , Wang Kelin , Kuzyakov Yakov 
Published: November 2020

Abstract
Background: Understanding the effects of straw return and nitrogen (N) fertilization on soil organic matter (SOM) transformations will help to mitigate climate change and maintain crop production and soil function. A 100-day soil incubation experiment was conducted using a two-factorial design with three fertilization levels and four 13C-labeled maize straw and N addition treatments. The competition and contributions of the bacterial and fungal communities were assessed with relation to straw mineralization.Results: Mineral fertilizer alone and with straw increased straw decomposition by 59% and 55% and SOM mineralization by 27% and 37%, respectively, compared with the unfertilized soil, due to raised β-N-acetylglucosaminidase and cellobiohyrolase activities. Conversely, priming effect was decreased by 59% and 39%, respectively. Priming effect increased with higher N additions and decreased with lower N additions because an improved C:N ratio for microorganisms. Straw additions increased bacterial and fungal abundance by 1.4 and 4.9 times. Fungal diversity decreased with N fertilization because lower C:N ratios increased the bacterial competition. Bacterial abundance decreased but diversity increased with the duration of incubation as bacteria preferred to utilize labile organic compounds abundant in the initial stages. Along with labile organic compounds depletion, fungal abundance was increased. Firmicutes, Actinobacteria, and Proteobacteria bacterial as well as Ascomycota, Basidiomycota, and Mucoromycota fungi dominated straw and SOM decomposition. Firmicutes were mostly involved in straw and SOM mineralization on day one because of their capacity for labile compound decomposition. Integrated co-occurrence networks revealed that fungal taxa had a stronger correlation with straw decomposition than bacterial groups. Straw and N addition increased the number of negative edges among bacterial taxa but these decreased within fungal groups when compared to trials without straw and N. The ratio for pairwise correlations between abundant fungal taxa, straw, and SOM mineralization (29.9%) was greater than with bacteria (1.2%).Conclusions: Straw with low N additions increased soil C sequestration by decreasing priming effect. Straw alone and with N addition decreased competition for C and N among fungal groups, but increased competition within bacterial taxa. Fungi outcompete bacteria for straw and soil organic matter mineralization in long-term fertilized soils.
Asymmetric Effects of Capital Flight on Domestic Investment in Nigeria: Evidence from Non-Linear Autoregressive Distributed Lag Model
Authors: EFFIOM LIONEL , UCHE EMMANUEL , OTEI OTEI ASUQUO , EFFIONG FRANCIS ARCHIBONG 
Published: November 2020

Abstract
Capital flight is a challenge for many developing countries. The problem is more severe in a nation like Nigeria where domestic investment has been affected. On theoretical grounds, domestic investment should be a decreasing function of capital flight, but is there a possibility that reversals or downturns in capital flight in Nigeria might lead to a decline in investment levels? Put differently, is there a tendency for domestic investment to maintain a downward spiral, a ratchet effect, even in the face of lower levels or magnitude of capital flight? This study is a modest first attempt at investigating these possibilities. Employing the nonlinear autoregressive distributed lag model (NARDL), the study finds evidence of asymmetric impact of capital flight on investment undertaken at the national level. However, investment by subnational governments revealed the existence of symmetry, while overall, total public sector investments (by both States and Federal Governments) indicated the existence of asymmetric effects between positive and negative deviations of capital flight. The paper re-echoes the need for the strengthening of institutions at all levels to curb the menace.
Enhancing Student Nurses’ Clinical Education in Aged Care Homes: A Qualitative Study of Challenges Perceived by Faculty Staff
Authors: Laugaland Kristin Alstveit , Billett Stephen , Akerjordet Kristin , Frøiland Christina , Grealish Laurie , Aase Ingunn 
Published: November 2020

Abstract
Background: The ageing population is increasing the demand for geriatric care services. As nursing schools respond to this demand, more clinical placements are required, and aged care homes are suitable placement sites. Although an aged care experience for students is beneficial, the basis for effective implementation of these placements is yet to be fully established. The aim of this study was to explore faculty staff perspectives on the challenges associated with providing clinical education in aged care homes to first-year student nurses.Methods: An exploratory qualitative study was conducted using in-depth interviews (n=15) with program leaders of nurse bachelor programs (n=4), course leaders (n=6) and practice coordinators (n=5) in three Norwegian universities. Data were analyzed using thematic analysis. The standards for Reporting of Qualitative Research (SRQR) checklist were used to report the findings. Results: Five themes describe the perceived challenges to implementing clinical education in aged care homes: (1) the staffing model limits capacity to host students; (2) prevalence of part-time teachers can compromise the quality of students’ learning experiences; (3) tension about required qualifications and competence exist; (4) variation in learning assessments; and (5) lack of quality assurance. Conclusions: These challenges signal key areas for attention in quality assurance for aged care placements. Further research into the minimum levels of staffing required to support student learning in the aged care setting is required. Methods for developing shared practices around facilitation of learning in aged care homes is required to address the preference for part-time teaching appointments. Further research into the levels of qualification and competence required to support student learning can assist with setting standards for this sector. Finally, academic-practice institutions must engage with bureaucrats and national nursing bodies to develop national standards for clinical education in aged care homes.
Identification of Differentially Expressed Genes and Signaling Pathways in Human Conjunctiva and Reproductive Tract Infected With Chlamydia Trachomatis
Authors: Zhu Guo-Dong , Cao Xun-Jie , Li Ya-Ping , Li Jia-Xin , Leng Zi-Jian , Xie Li-Min , Guo Xu-guang 
Published: November 2020

Abstract
BackgroundCurrently, Chlamydia trachomatis–specific host defense mechanisms in humans remain poorly defined. To study the characteristics of host cells infected early with chlamydia trachomatis, we used bioinformatics methods to analyze the RNA transcription profiles of the conjunctiva, fallopian tubes, and endometrium in humans infected with chlamydia trachomatis.MethodThe gene expression profiles of GSE20430, GSE20436, GSE26692, and GSE41075 were downloaded from the Gene Expression Synthesis (GEO) database. Then we obtained the differentially expressed genes (DEGs) through the R 4.0.1 software. STRING was used to construct protein–protein interaction (PPI) networks, then the Cytoscape 3.7.2 software was used to visualize the PPI and screen hub genes. GraphPad Prism 8.0 software was used to verify the expression of the hub gene. In addition, the gene–miRNA interaction was constructed on the NetworkAnalyst 3.0 platform using the miRTarBase v8.0 database ResultsA total of 600 and 135 DEGs were screened out in the conjunctival infection group and the reproductive tract infection group, respectively. After constructing a PPI network and verifying the hub genes, CSF2, CD40, and CSF3 in the reproductive tract infection group proved to have considerable statistical significance.ConclusionIn our research, the key genes in the biological process of reproductive tract infection with Chlamydia trachomatis were clarified through bioinformatics analysis. These hub genes may be further used in clinical treatment and clinical diagnosis.
The Impact of COVID-19 on Hip Fracture Management in a Tertiary Referral Hospital; Pearls and Pitfalls.
Authors: MG Curran , P Hickey , C Reddin , R Murphy , NA Mohd Asri , Lenehan B , F Condon , J Ryan 
Published: November 2020

Abstract
Background COVID-19 has caused significant challenges in the provision of safe and effective healthcare globally. Safeguarding the management of frail older adults is imperative in hip fracture care moving forward. Aims This study aimed to compare clinical outcomes of hip fracture care during the COVID-19 pandemic with the same timeframe in 2019, following significant reconfigurations in hip fracture management pathways during the pandemic. Methods We conducted a retrospective study comparing all patients treated for a hip fracture between two timeframes; March 1st2020 - May 1st 2020 and March 1st 2019 – May 1st 2019. Data was collected using the Irish Hip Fracture Database and the UHL electronic patient administration system. Results 118 patients were included in the study; 60 patients in the COVID-19 cohort and 58 patients in the control cohort. Demographic characteristics were comparable between groups. Improvements in adherence to Irish Hip Fracture Standards were noted during the COVID-19 cohort, however they were not significant. Three patients tested positive for COVID-19 during the timeframe of interest. Their length of stay (LOS) was noticeably longer than the median LOS of both groups. A significant decrease in femoral nerve blocks was noted during the COVID-19 cohort (p = < 0.001). There was a trend towards higher inpatient mortality, 30 day mortality rates and 30 day readmission in the COVID-19 cohort which was not statistically significant. ConclusionsOur study demonstrates continued adherence to the Irish Hip Fracture Standards at our institution and suggests the necessary alterations in hip fracture management did not negatively impact patient outcomes during the COVID-19 pandemic.
Detection of SARS-CoV-2 in Different Body Fluids Using RT-PCR – An Autopsy Based Study
Authors: KYADA HETAL , TRANGADIA MAHESH , VADGAMA DIVYESH , VARU PRATIK , BHUVA SHAILESH , MANVAR PRINCE , RATHOD BHOOMI 
Published: November 2020

Abstract
World is in mid of dreaded pandemic – Covid-19 caused by SARS-CoV-2. To curb it tremendous efforts has been put worldwide to enhance scientific knowledge related to SARS-CoV-2. In this study, we collected postmortem samples of tracheal swab, vitreous humor, pleural fluid, CSF and pericardial fluid by conducting complete autopsy on 24 patients with known SARS-CoV-2 infection at department of forensic medicine, P.D.U. Government College, Rajkot (India). RT-PCR was used to detect SARS-CoV-2 from these samples. SARS-CoV-2 was detected from tracheal swab in 54.55% cases and from pleural fluid in 13.34% cases. SARS-CoV-2 wasn’t detected from any sample of CSF, vitreous humor and pericardial fluid. Positive and negative cases for postmortem tracheal swabs were analyzed to find out of its relationship with duration of Covid-19 illness. No significant relationship was found between detectability of SARS-CoV-2 in postmortem samples of tracheal swab and duration of Covid-19 illness.
Recent Advances in Nanotechnology: A Novel Therapeutic System for the Treatment of Alzheimer’s Disease
Authors: Chauhan Pallavi Singh , Yadav Dhananjay , Koul Bhupendra , Mohanta Yugal Kishore , Jin Jun-O 
Published: November 2020

:
A amyloid-β (Aβ) plaque formation in the brain is known to be the root cause of Alzheimer’s disease
(AD), which affects the behavior, memory, and cognitive ability in humans. The brain starts undergoing
changes several years before the actual appearance of the symptoms. Nanotechnology could prove to be an alternative
strategy for treating the disease effectively. It encompasses the diagnosis as well as the therapeutic aspect
using validated biomarkers and nano-based drug delivery systems, respectively. A nano-based therapy
may provide an alternate strategy, wherein one targets the protofibrillar amyloid-β (Aβ) structures, and this is
followed by their disaggregation as random coils. Conventional/routine drug therapies are inefficient in crossing
the blood-brain barrier; however, this hurdle can be overcome with the aid of nanoparticles. The present review
highlights the various challenges in the diagnosis and treatment of AD. Meticulous and collaborative research
using nanotherapeutic systems could provide remarkable breakthroughs in the early-stage diagnosis and
therapy of AD.
Perubahan Nilai Tanah Zonasi Kawasan di Desa Kutuh Sejak Berkembangnya Obyek Daya Tarik Wisata Pantai Pandawa
Authors: Nuharta I Gede Kurnia , Muktibowo Antonius Karel , Paturusi Syamsul Alam 
Published: November 2020

Tanah sangat penting bagi kehidupan manusia karena tanah merupakan tempat utama dari semua kegiatan yang dilakukan oleh manusia. Sebagai sumber kesejateraan dan kemakmuran, tanah memiliki nilai berdasarkan kemampuannya secara ekonomis dalam hubungannya dengan produktifitas dan strategi ekonomisnya. Salah satu faktor yang mempengaruhi nilai tanah adalah faktor permintaan dan faktor penawaran sangat terkait dengan jumlah persediaan tanah dan kebutuhan tanah. Sejalan dengan itu perkembangan pariwisata akan membawa berbagai dampak perubahan. Salah satu dampak sosial ekonomi masyarakat dari perkembangan pariwisata diantaranya adalah perubahan nilai lahan. Berdasarkan latar belakang fenomena diatas sangat menarik untuk dikaji dampak perkembangan obyek daya tarik pariwisata Pantai Pandawa terhadap perubahan nilai tanah di Desa Kutuh. Adapun tujuan dari penelitian menganalisis perubahan nilai tanah zonasi kawasan yang hasilnya dapat digunakan sebagai pengetahuan pendukung dalam penataan ruang wilayah. Penelitian ini menggunakan metode penelitian kuantitatif dengan pendekatan spasial melalui teknik analisis spasial yaitu timpang susun (overlay) peta menggunakan Sistem Informasi Geografis (SIG) dan analisis statistik deskriptif untuk menganalisis perubahan nila tanah zonasi kawasan dan menyajikan hasil analisis dalam bentuk tabel dan grafik. Hasil dari penelitian terjadi perubahan nilai tanah di Desa Kutuh dengan peningkatan nilai tanah rata-rata zonasi kawasan sejak tahun 2012 sampai dengan 2018 pada zona pariwisata sebesar 7.08 %; zona perdagangan jasa 10.65 %; zona perkantoran 7.18 %; zona pertanian 5.02%; zona perumahan 4.45%; zona peruntukan lainya 4.95 % dan zona sarana pelayanan umum 10.78%. Berdasarkan hasil analsis perubahan nilai tanah rata-rata zonasi kawasan di Desa Kutuh diperoleh bahwa zonasi pelayanan umum yang berada dikawasan obyek daya tarik obyek wisata Pantai Pandawa memiliki peningkatan nilai tanah zonasi rata-rata kawasan tertinggi dengan demikian bahwa dampak perkembangan obyek daya tarik pariwisata Pantai Pandawa mengakibatkan naiknya nilai tanah di Desa Kutuh.