bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationships of diabetes and hyperglycaemia with intraocular pressure in a Japanese population: the JPHC-NEXT Eye Study
Authors: Hanyuda Akiko , Sawada Norie , Yuki Kenya , Uchino Miki , Ozawa Yoko , Sasaki Mariko , Yamagishi Kazumasa , Iso Hiroyasu , Tsubota Kazuo , Tsugane Shoichiro 
Published: March 2020

AbstractAlthough a meta-analysis previously suggested a positive relationship between diabetes and intraocular pressure (IOP), the interrelationships among diabetes, IOP, and other ocular biometric parameters remain unclear. The present study investigated the relationships of diabetes, haemoglobin A1c (HbA1c), and serum glucose with IOP and ocular hypertension (IOP > 21 mmHg) in non-glaucomatous Japanese adults living in Chikusei City. Diabetes was defined as a self-reported history of diabetes, the use of antidiabetic medication, or HbA1c levels ≥6.5%. Among 6,786 enrolled participants aged 40 years and above, 734 were classified as diabetic (10.8%). After adjusting for several confounders, the IOP values were significantly higher in participants with diabetes than in those without diabetes (14.4 ± 0.1 vs. 13.9 ± 0.1 mmHg, P < 0.001) and were also significantly increased in those with elevated HbA1c and serum glucose levels (both P < 0.001). Moreover, diabetes was significantly related to ocular hypertension (multivariable-adjusted odds ratio, 1.75; 95% confidence interval, 1.09–2.81; P < 0.05). The positive influence of diabetes with ocular hypertension was consistent even after adjustment for central corneal thickness. In conclusion, diabetes, elevated HbA1c, and increased serum glucose are significant contributing factors for elevated IOP.
Evidence that ERF transcriptional regulators serve as possible key molecules for natural variation in defense against herbivores in tall goldenrod
Authors: Takafuji Kento , Rim Hojun , Kawauchi Kentaro , Mujiono Kadis , Shimokawa Saki , Ando Yoshino , Shiojiri Kaori , Galis Ivan , Arimura Gen-ichiro 
Published: March 2020

AbstractWe collected Solidago altissima clones to explore their leaf damage resistance, and as a result identified five accessions that exhibited variable defense abilities against the generalist herbivore Spodoptera litura. In order to characterize molecules involved in such natural variation, we focused on ethylene response factors (ERFs) that exhibited distinct transcription patterns in the leaves of the five accessions (e.g., S1 and S2) after wounding: the transcript of SaERF1 and SaERF2 was induced in wounded S1 and S2 leaves, respectively. Although transcription levels of SaERFs in leaves of the five accessions did not correlate with the accessions’ phytohormone levels, these transcription levels accorded with the possibility that ethylene and jasmonate signaling play crucial roles in wound-induced transcription of SaERF1 in S1 leaves, and SaERF2 in S2 leaves, respectively. SaERF1 was found to be a positive regulator of the GCC box and DRE element in the upstream regions of promoters of defense genes, whereas SaERF2 served as a negative regulator of genes controlled through the GCC box. Transgenic Arabidopsis plants expressing SaERF1 or SaERF2 showed enhanced and suppressed transcript levels, respectively, of a defensin gene, indicating that ERFs may be partly responsible for herbivore resistance properties of S. altissima accessions.
Stillbirth risk prediction using machine learning for a large cohort of births from Western Australia, 1980–2015
Authors: Malacova Eva , Tippaya Sawitchaya , Bailey Helen D. , Chai Kevin , Farrant Brad M. , Gebremedhin Amanuel T. , Leonard Helen , Marinovich Michael L. , Nassar Natasha , Phatak Aloke , Raynes-Greenow Camille , Regan Annette K. , Shand Antonia W. , Shepherd Carrington C. J. , Srinivasjois Ravisha , Tessema Gizachew A. , Pereira Gavin 
Published: March 2020

AbstractQuantification of stillbirth risk has potential to support clinical decision-making. Studies that have attempted to quantify stillbirth risk have been hampered by small event rates, a limited range of predictors that typically exclude obstetric history, lack of validation, and restriction to a single classifier (logistic regression). Consequently, predictive performance remains low, and risk quantification has not been adopted into antenatal practice. The study population consisted of all births to women in Western Australia from 1980 to 2015, excluding terminations. After all exclusions there were 947,025 livebirths and 5,788 stillbirths. Predictive models for stillbirth were developed using multiple machine learning classifiers: regularised logistic regression, decision trees based on classification and regression trees, random forest, extreme gradient boosting (XGBoost), and a multilayer perceptron neural network. We applied 10-fold cross-validation using independent data not used to develop the models. Predictors included maternal socio-demographic characteristics, chronic medical conditions, obstetric complications and family history in both the current and previous pregnancy. In this cohort, 66% of stillbirths were observed for multiparous women. The best performing classifier (XGBoost) predicted 45% (95% CI: 43%, 46%) of stillbirths for all women and 45% (95% CI: 43%, 47%) of stillbirths after the inclusion of previous pregnancy history. Almost half of stillbirths could be potentially identified antenatally based on a combination of current pregnancy complications, congenital anomalies, maternal characteristics, and medical history. Greatest sensitivity is achieved with addition of current pregnancy complications. Ensemble classifiers offered marginal improvement for prediction compared to logistic regression.
Speciation of chromium in waters using dispersive micro-solid phase extraction with magnetic ferrite and graphite furnace atomic absorption spectrometry
Authors: López-García Ignacio , Marín-Hernández Juan José , Hernández-Córdoba Manuel 
Published: March 2020

AbstractThe combination of a solid-phase microextraction process with graphite furnace atomic absorption spectrometry provides a very sensitive determination method for determining chromium in waters. Freshly prepared ferrite particles are used to retain the chromium species, and then separated by a magnet without the need for a centrifugation step. The solid phase is suspended in water and directly introduced into the graphite furnace to obtain the analytical signal. The complexation of Cr(III) with ethylenediaminetetraacetate allows the selective retention of Cr(VI), and thus the speciation of the metal. The procedure is sensitive (0.01 µg L−1detection limit when using a 10 mL sample aliquot) and reproducible (5% relative standard deviation for five consecutive experiments at the 0.3 µg L−1level). The reliability of the procedure is verified by analysing five certified water samples.
Circulating Diabetic Candidate Neurotrophic Factors, Brain-Derived Neurotrophic Factor and Fibroblast Growth Factor 21, in Sleeve Gastrectomy
Authors: Yen Hung-Hsuan , Hsieh Sung-Tsang , Chen Chi-Ling , Yang Wei-Shiung , Lee Po-Chu , Lin Ming-Tsan , Chen Chiung-Nien , Yang Po-Jen 
Published: March 2020

AbstractRecent studies show brain-derived neurotrophic factor (BDNF) and fibroblast growth factor 21 (FGF21) are neurotrophic factors associated with obesity and diabetes mellitus (DM). Laparoscopic sleeve gastrectomy (LSG) can significantly reduce weight and improve DM. In this study, we enrolled 78 patients with obesity and evaluated the change of BDNF and FGF21 6 months after LSG. At baseline, the BDNF level was similar between the preoperative DM (n = 30) (17.1 ± 7.7 ng/ml) and non-DM (n = 48) (17.0 ± 6.9 ng/ml) patients with obesity, but FGF21 was significantly higher in the DM patients (201.5 ± 204.3 versus 107.6 ± 63.8 pg/ml). At 6 months after LSG, most of the preoperative DM patients (96.7%) had DM either resolved (66.7%) or improved (30%). BDNF increased and FGF21 decreased significantly regardless of the preoperative DM status, while FGF21 decreased more prominently in the preoperative DM patients (−92.6 ± 179.8 versus −4.6 ± 63.4 pg/ml). After adjusted for age, sex, and preoperative DM status, FGF21 became significantly and positively related to C-peptide (β = 18.887), insulin (β = 2.399), and homeostasis model assessment of insulin resistance index (β = 8.566) after surgery. In conclusion, diabetic patients with obesity had higher FGF21 and similar BDNF levels compared to non-diabetic obese patients. BDNF increased and FGF21 decreased significantly after LSG. FGF21 became positively associated with several insulin-related profiles after surgery.
Future exacerbation of hot and dry summer monsoon extremes in India
Authors: Mishra Vimal , Thirumalai Kaustubh , Singh Deepti , Aadhar Saran 
Published: March 2020

AbstractSummer monsoon (June-September) precipitation is crucial for agricultural activities in India. Extremes during the monsoon season can have deleterious effects on water availability and agriculture in the region. Here, we show that hot and dry extremes during the summer monsoon season significantly impact food production in India and find that they tend to occur during El Niño years during the observed record of 1951–2018. We then use an ensemble of climate simulations for the historic (1971–2000) and future (2006–2100) that capture this coupling between El Niño and the Indian monsoon to show that the frequency of concurrent hot and dry extremes increases by a factor of 1.5 under continued greenhouse warming during the 21st century. Despite projections of summer monsoon intensification on the order of ~10%, the rise in surface air temperatures as well as increase in rainfall variability contributes to more severe hot and dry monsoon extremes over India, thereby posing a substantial challenge to future food security in India.
The +2 oxidation state of Cr incorporated into the crystal lattice of UO2
Authors: Sun Mengli , Stackhouse Joshua , Kowalski Piotr M. 
Published: March 2020

AbstractDoping by Cr is used to improve the performance of uranium dioxide (UO2)-based nuclear fuel. However, the mechanism of structural incorporation of Cr remains unclear. Here, in order to understand this process on the atomic scale and the redox state of Cr in UO2-based nuclear fuel, we performed intensive ab initio atomistic simulations of the Cr doped UO2 matrix. We unexpectedly found that Cr in UO2 exists as Cr2+ species and not as the widely claimed Cr3+. We re-evaluated previously published x-ray absorption near edge structure spectroscopy data and confirmed the computed redox state of Cr. Thermodynamic consideration shows that the favorable structural arrangement of Cr in UO2 is given by a pair of associated Cr2+ and oxygen vacancy. The realism of this doping mechanism is further demonstrated by a match to the measured maximum Cr solubility and small lattice contraction.
Longitudinal Development of Executive Functioning and Spoken Language Skills in Preschool-Aged Children With Cochlear Implants
Authors: Kronenberger William G. , Xu Huiping , Pisoni David B. 
Published: March 2020

Purpose

Auditory deprivation has downstream effects on the development of language and executive functioning (EF) in prelingually deaf children with cochlear implants (CIs), but little is known about the very early development of EF during preschool ages in children with CIs. This study investigated the longitudinal development of EF and spoken language skills in samples of children with normal hearing (NH;
N
= 40) or CIs (
N
= 41) during preschool ages.

Method
Participants were enrolled in the study between ages 3 and 6 years and evaluated annually up to the age of 7 years. Mixed-effects models were used to evaluate and predict growth of spoken language and EF skills over time.

Results
Children with CIs scored lower than NH peers on language measures but improved significantly over time. On performance-based neurocognitive measures of controlled attention, inhibition, and working memory, children with CIs scored more poorly than the sample of NH peers but comparable to norms, whereas on a parent report behavior checklist, children with CIs scored more poorly than both NH peers and norms on inhibition and working memory. Children with CIs had poorer EF than the sample of NH peers in most domains even after accounting for language effects, and language predicted only the verbal working memory domain of EF. In contrast, EF skills consistently predicted language skills at subsequent visits.

Conclusions
Findings demonstrate that, despite significant improvement over time, some domains of EF (particularly parent-reported EF) and language skills in children with CIs lag behind those of children with NH during preschool ages. Language delays do not fully explain differences in EF development between children with CIs and NH peers during preschool ages, but EF skills predict subsequent language development in children with CIs.
Peroral endoscopic myotomy (POEM): a comparative study between Chagasic and idiopathic achalasia
Authors: Farias Galileu F.A. , de Moura Diogo T.H. , de Moura Eduardo T.H. , de Rezende Daniel T. , Hathorn Kelly E. , Nasi Ary , Queiroz Natália S.F. , de Moura Eduardo G.H. 
Published: March 2020

Abstract
Background and study aims Achalasia can be classified as either primary (idiopathic) achalasia or secondary achalasia, which is a consequence of another systemic disease. Peroral endoscopic myotomy (POEM) is an effective and safe treatment for achalasia. We evaluated the efficacy and safety of POEM in patients with Chagasic achalasia compared to idiopathic achalasia.
Patients and methods We evaluated POEM procedures performed at a single institution from November 2016 to January 2018. Demographic data, Eckardt score, lower esophageal sphincter (LES) pressure, body mass index, post-operative erosive esophagitis, adverse events, length of hospital stay, and procedure-related parameters were analyzed.
Results Fifty-one patients underwent POEM as a treatment for achalasia in this period (20 patients with Chagasic and 31 with Idiopathic etiology). The overall clinical success rate was 92.1 %, with no statistical difference between groups (90 % in the Chagasic group vs. 93.5 % in the Idiopathic group, P = 0.640). Both groups had significant reduction in Eckardt score and in LES pressure, and increase in bodey mass index (BMI) at 1-year follow-up. There was no statistical difference between groups regarding Eckardt score (P = 0.439), LES pressure (p = 0.507), BMI (P = 0.254), post erosive esophagitis (35 % vs. 38.7 %, P = 0.789), adverse events (30 % vs. 12 %, P = 0.163,) length of hospital stay (3.75 days vs. 3.58 days, P = 0.622), and operative time (101.3 min vs. 99.1 min, P = 0.840).
Conclusion POEM is an effective and safe treatment for patients with achalasia. There is no difference in POEM outcomes for those patients with Chagasic or Idiopathic achalasia.
Successful repair of wide traumatic rectal perforation using over-the-scope clip
Authors: Manno Mauro , Deiana Simona , Gabbani Tommaso , Vavassori Sara , Ottaviani Laura , Soriani Paola 
Published: March 2020

Abstract
Background and study aims We report on a case of a traumatic rectal perforation that occurred in a 16-year-old girl, which was successfully treated using an over-the-scope clip, avoiding major surgery and stoma.
Applied solidarity in times of crisis: exploring the contexts of civil society activities in Greece and Germany
Authors: Durán Mogollón Lía , Eisele Olga , Paschou Maria 
Published: March 2020

AbstractThe European ‘crisis decade’ triggered discussions about solidarity and it´s limits; at the policy level, the debates were mostly about determining thedeservingnessof solidarity of each vulnerable group, and at the street level, actors involved saw the demand for concrete service provision grow while their resources stayed the same or retrenched. This paper is interested in the limits of solidarity precisely at the street level; hence we investigate what combinations of operational conditions (budget, status, volunteers) lead the civil society organizations to engage in more solidarity activities (service provision and advocacy). Civil Society Organizations (CSOs) are, beside the state and the family, a vital provider of solidarity services and a significant actor in advocacy for vulnerable groups. As any organization, CSOs are rationalised structures that pursue a concrete goal and for this purpose, rely on different resources and strategies. The paper, therefore, investigates configurations of operational conditions that account for higher levels of solidarity activities by CSOs in Germany and Greece. These countries have both experienced an increase in the demand of social services while they present different civil society traditions, different welfare systems and have been differently affected by crises. While Germany was less dramatically affected by the financial crisis and voluntarily took in almost a million refugees in 2016, Greece was severely hit by the financial crisis and, located at the EU borderland, has had a different experience with the inflow of migrants and refugees. The analysis builds on a series of semi-structured interviews conducted with CSO representatives of the social sector in the framework of the TransSOL project (www.transsol.eu) in 2017. We employ a fuzzy set qualitative comparative analysis (QCA) to understand the necessary and sufficient conditions under which CSOs are more active, looking at their organizational traits and preconditions, their capacities to mobilise volunteers, their status in the community and their cross-sectional coverage of social issues.
A Framework for Requirements Prioritization Process in Agile Software Development
Authors: AbdElazim Khaled , Moawad Ramadan , Elfakharany Essam 
Published: March 2020

Abstract
Requirements engineering is a crucial phase of software engineering, and requirements prioritization is an essential stage of requirements engineering particularly in agile software development. Requirements prioritization goals at eliciting which requirements of software need to be covered in a particular release. The key point is which requirement will be selected in the next iteration and which one will be delayed to other iterations for minimizing risk during development and meeting stakeholders’ needs. There are many existing techniques for requirement prioritization, but most of these techniques do not cover continuous growth and change of requirements or cover requirements dependencies. So, most of these prioritization techniques need to be more continuous, scalable, implemented merely and integrated with software development life cycle and not work separately. This paper introduces a framework to prioritize requirements in agile software development. This framework tries to find solutions for the challenges facing this prioritization process such as how to make this prioritization continuous and scalable and how to deal with rapidly requirement changes and its dependencies.
Mapping the potential pollution of fisheries industry wastewater in the Southern Coast of Jember Regency: Preliminary study on wastewater management planning
Authors: Ariyunita S , Listyawati R N 
Published: March 2020

Abstract
Fisheries industries produce wastewater as by-product. Based on preliminary surveys, there is no integrated wastewater management in the Southern Coast of Jember Regency where the centre fisheries industry was taken place. This study aims to find areas that are potentially polluted by fisheries industries wastewater and offer the information for planning integrated wastewater management in the coastal area of Jember Regency. We collected primary and secondary data about fish processing production and the impact of wastewater for environment. The results were analysed descriptively and potentially polluted areas were mapped with Arc-Gis software. The study area involves two sub-districts, Puger and Ambulu sub-district. Surveys conducted to 16 fisheries industries showed that 81.25% of them discharged the untreated wastewater into the stream directly. Wastewater disposal into the stream not only cause pollution in water bodies but also cause pollution in the Indian Ocean.
Process simulation of power screw failure on fatigue load using autodesk inventor
Authors: Mustika V , Triono A , Wibowo R K K 
Published: March 2020

Abstract
The paper presents the study on the use of simulation software in manufacturing industry. It is perceived as a tool for visualization of an on-going process in fatigue load. The design of this study is to simulate the stress distribution due to the loading of the power screw (or lead screw) fatigue using Autodesk Inventor software simulation version 2018. Power screw used is steel material with a round bar shape. It is called medium carbon steel (S 45 C) with specifications of tensile strength at 48 kg/mm2, creep limit at 29 kg/mm2, hardness range (Hs) of 137 to 197 kg/mm2, chemical elements in a percentage of 0.27 to 0.33, Si of 0.15 to 0.35, Mn of 0.60 to 0.90, P of 0.030 and, S of 0.035. The modeling used in this study is by finite element method analysis, which consist of several steps. The steps involve 3D geometry design based on the existing dimension, importing the CAD (Computer Aided Drawing) of 3D geometry design to finite element software, engineering the data by entering the mechanical properties, meshing which indicate the limit of the geometry of the model into numbers of elements in the properties, determining the fixed position of the central points of the static load and fatigue load given to power screw components application, and determining the coordinate system for the solution. The results shows the mechanical properties of S45C carbon steel power screw. It has a maximum von mises stress of 4.546 MPa with the first principal stress of 4.518 MPa. The third principal stress of the material is 0.538 MPa, the displacement is 0.001602 mm, and safety factor is 15 ul.
Diversity of freshwater crab (decapoda) in meru betiri national park
Authors: Susilo V E , Suratno  , Wowor D , Abror M N 
Published: March 2020

Abstract
The abundance of flora and fauna in tropical forests throughout Indonesia is very high. Indonesian fauna shows its diversity in terms of ecology found in various ecosystem types. One of them is freshwater ecosystem. Freshwater crabs have a wide habitat distribution so they can be found in various forms of freshwater. This study aimed to determine the level of diversity and determine the abiotic conditions of freshwater crab habitat. The location determination of sampling was done purposively along with road sampling. The tools used to catch freshwater crabs were bubu and tray net. The results obtained in the Meru Betiri National Park, especially in Andongrejo and Bandealit resorts, revealed that five species of freshwater crabs consist of three families. The diversity index of freshwater crabs in both resorts is relatively low. That is because most freshwater crab species belongs to endemic animals because of their limited spreading ability, relatively low fecundity, and stenotopic habits. Meru Betiri National Park has abiotic conditions that are ideal for supporting freshwater crab life.
Super edge local antimagic total labeling of some graph operation
Authors: Karimah M , Dafik  , Slamin  , Kurniawati E Y , Agustin I H 
Published: March 2020

Abstract
Let G be a simple connected, and undirected graph. Graph G has a set of vertex denoted by V(G) and a set of edge denoted by E(G). d(v) is the degree of vertex v ∈ V(G) and Δ(G) is the maximum degree of G. A total labeling of graph G(V, E) is said to be local edge antimagic total labeling if a bijection f : V(G) ∪ E(G) → {1, 2, 3, …, |V(G)| + |E(G)|} such that for any two adjacent edges e
1 and e
2, wt
(e
1) ≠ wt
(e
2), where for e = uv ∈ G, wt
(e) = f(u) + f(uv) + f(v). The local edge antimagic total labeling induces a proper edge coloring of G if each edge e is assigned the color wt
(e). The edge local antimagic chromatic number of G denoted by γelat
(G), is the minimum number of distinct color induced by edge weights over all local antimagic total labeling of G. In this paper, we determined the edge local antimagic chromatic number of Diamond Ladder graph, Pn
⊙ Pm
Three Circular ladder graphht, and shack(F
2, v, n).