bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the Association Between Osteoarthritis and Social Participation: The Canadian Longitudinal Study on Aging
Authors: Perruccio Anthony V. , Yip Calvin , Power J. Denise , Canizares Mayilee , Gignac Monique A. M. , Badley Elizabeth M. 
Published: June 2020

ObjectiveThe focus on disability in osteoarthritis (OA) has largely been on the ability to perform specific activities, which neglects the greater implications for social participation. We investigated the association between OA and social participation, considering activity limitations and instrumental supports as intervening variables in the association.MethodsData were from 21,214 respondents, ages 45–85 years, from cycle 1 of the Canadian Longitudinal Study on Aging. The questionnaire elicited information regarding self‐reported doctor‐diagnosed OA, difficulty with 14 activities, perceived availability and receipt of instrumental supports, and 17 social participation activities. Structural equation modeling was used. The primary outcome was social participation, and the primary predictor was OA. The intervening variables included activity limitations, received instrumental supports, and perceived instrumental supports. Latent variables were developed for intervening and social participation variables. The covariates included age, sex, body mass index, income, education, smoking, and comorbidity count.ResultsThe mean age of the respondents was 63 years, 51% were female, and 26.5% reported having OA. Two distinct social participation indicators were identified, including social participation–diversity and social participation–intensity. When intervening variables were not considered, minimal/no association was found between OA and social participation. When intervening variables were considered, unique pathways linking OA and social participation were found. The overall negative association between activity limitations and social participation was partially direct and partially buffered by both receipt of and perceived availability of instrumental supports. In the absence of activity limitations, OA was associated with greater social participation.ConclusionEnhanced social participation in people with OA who do not have activity limitations may reflect proactive steps taken by those with mild OA to maintain activity and social engagement. For those with activity limitations, findings highlight the need for interventions to mitigate limitations and draw particular attention to the importance of both provision and awareness of available instrumental supports in maintaining social participation.
Applying the 2019 European Alliance of Associations for Rheumatology/American College of Rheumatology Lupus Criteria to Patients From the LUMINA Cohort: Results From the Multiethnic, Multicenter US Cohort
Authors: Ugarte‐Gil Manuel F. , Pons‐Estel Guillermo J. , Harvey Guillermina B. , Vilá Luis M. , Griffin Russell , Alarcón Graciela S. 
Published: June 2020

ObjectiveTo evaluate the performance of the 2019 European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) criteria for systemic lupus erythematosus (SLE) in terms of earlier SLE classification in comparison to the ACR or the Systemic Lupus International Collaborating Clinics (SLICC) criteria.MethodsPatients from a multiethnic, multicenter cohort, the Lupus in Minorities: Nature versus Nurture cohort, where SLE was defined using the 1982/1997 ACR criteria were included. Demographic, clinical, and immunologic criteria were compared among the 2019 EULAR/ACR and the 1982/1997 ACR and the 2012 SLICC timing categories.ResultsThe 2019 EULAR/ACR criteria allowed an earlier SLE classification in 13.3% of patients (mean 0.66 years) and 15.3% of patients (mean 0.63 years) compared to the 1982/1997 ACR and the 2012 SLICC criteria, respectively. Patients accruing the 2019 EULAR/ACR criteria later than the 1982/1997 ACR criteria had a lower disease activity, were less likely to have positivity to anti–double‐stranded DNA and anti‐Sm, as well as lupus nephritis classes II or V; they were more likely to have mucocutaneous manifestations, serositis, leukopenia, and antiphospholipid antibodies positivity. These differences were less pronounced when compared to the 2012 SLICC criteriaConclusionThe 2019 EULAR/ACR criteria classified SLE patients earlier than the 2 other criteria sets in real‐life clinical practice scenarios in a relatively small proportion of the patients. However, these criteria could allow earlier classification of a subset of patients with a more severe disease.
A‐Site Cation Engineering of Metal Halide Perovskites: Version 3.0 of Efficient Tin‐Based Lead‐Free Perovskite Solar Cells
Authors: Gao Weiyin , Chen Changshun , Ran Chenxin , Zheng Hao , Dong He , Xia Yingdong , Chen Yonghua , Huang Wei 
Published: June 2020

AbstractPb‐based metal halide perovskites (MHPs) have emerged as efficient light absorbers in third‐generation photovoltaic devices, and the latest certified power conversion efficiency (PCE) of Pb‐based perovskite solar cells (PSCs) has reached 25.2%. Despite great progress, Pb‐based MHPs are affected by toxicity, which hinders their market entry in a potential future large‐scale commercialization effort. Therefore, the exploration of Pb‐free MHPs has become one of the alternative solutions sought in the community. Among all the Pb‐free MHPs, Sn‐based MHPs show great promise owing to their similar or even superior theoretical optoelectronic characteristics. After several years of development, the PCE of Sn‐based PSCs has recently been approaching 10%, with the breakthroughs mainly coming from A‐site cation engineering of Sn‐based MHPs. In this review, the crucial status of A‐site cation engineering strategies in the research of Sn‐based PSCs is highlighted. First, the way the features of A‐site cation influence the structure and characteristics of MHPs is systematically demonstrated. Then, the state‐of‐the‐art developments, focusing on A‐site cation engineering of Sn‐based MHPs, are comprehensively reviewed. Subsequently, the current challenges and opportunities for further boosting the performance of Sn‐based PSCs are discussed. Finally, conclusions and perspectives on the promising Sn‐based optoelectronic devices are discussed.
Scaffolds Functionalized with Matrix from Induced Pluripotent Stem Cell Fibroblasts for Diabetic Wound Healing
Authors: Santarella Francesco , Sridharan Rukmani , Marinkovic Milica , Do Amaral Ronaldo Jose Farias Correa , Cavanagh Brenton , Smith Avi , Kashpur Olga , Gerami‐Naini Behzad , Garlick Jonathan A. , O'Brien Fergal J. , Kearney Cathal J. 
Published: June 2020

AbstractDiabetic foot ulcers (DFUs) are chronic wounds, with 20% of cases resulting in amputation, despite intervention. A recently approved tissue engineering product—a cell‐free collagen‐glycosaminoglycan (GAG) scaffold—demonstrates 50% success, motivating its functionalization with extracellular matrix (ECM). Induced pluripotent stem cell (iPSC) technology reprograms somatic cells into an embryonic‐like state. Recent findings describe how iPSCs‐derived fibroblasts (“post‐iPSF”) are proangiogenic, produce more ECM than their somatic precursors (“pre‐iPSF”), and their ECM has characteristics of foetal ECM (a wound regeneration advantage, as fetuses heal scar‐free). ECM production is 45% higher from post‐iPSF and has favorable components (e.g., Collagen I and III, and fibronectin). Herein, a freeze‐dried scaffold using ECM grown by post‐iPSF cells (Post‐iPSF Coll) is developed and tested vs precursors ECM‐activated scaffolds (Pre‐iPSF Coll). When seeded with healthy or DFU fibroblasts, both ECM‐derived scaffolds have more diverse ECM and more robust immune responses to cues. Post‐iPSF‐Coll had higher GAG, higher cell content, higher Vascular Endothelial Growth Factor (VEGF) in DFUs, and higher Interleukin‐1‐receptor antagonist (IL‐1ra) vs. pre‐iPSF Coll. This work constitutes the first step in exploiting ECM from iPSF for tissue engineering scaffolds.
DNA‐Based Plasmonic Heterogeneous Nanostructures: Building, Optical Responses, and Bioapplications
Authors: Zhao Yuan , Xu Chuanlai 
Published: June 2020

AbstractThe integration of multiple functional nanoparticles into a specific architecture allows the precise manipulation of light for coherent electron oscillations. Plasmonic metals‐based heterogeneous nanostructures are fabricated by using DNA as templates. This comprehensive review provides an overview of the controllable synthesis and self‐assembly of heterogeneous nanostructures, and analyzes the effects of structural parameters on the regulation of optical responses. The potential applications and challenges of heterogeneous nanostructures in the fields of biosensors and bioanalysis, in vivo monitoring, and phototheranostics are discussed.
Surface roughness effect on optical loss in waveguide using isotropically induced crosslink network of siloxane–polyimide copolymer
Authors: Mohd Ibrahim Noor Farahin , Ramli Mohamad Riduwan , Rusli Arjulizan , Abd Rahman Mohd Kamil , Ahmad Zulkifli 
Published: June 2020

AbstractOptical properties of two‐fluorinated polysiloxane‐co‐polyimide (PI‐PDMS and 3‐(aminopropyl)triethoxysilane [PI‐APTES]) were investigated based on their molecular structure and compared with the pure PI at 1,550 nm radiation. The refractive indexes and birefringence of the copolymers were reduced which is attributable to the chain flexibility as substantiated from the differential scanning calorimetry result. They are highly transparent at near infrared (NIR) region with light transmittance above 90% at visible region while displaying excellent thermal stability up to 456°C. Asymmetry planar waveguides was fabricated which recorded a respectable low optical loss 0.020 dB/cm for pure PI, 0.042 dB/cm for PI‐PDMS, and 0.066 dB/cm for PI‐APTES, respectively. Despite proving low NIR absorption and low birefringence, extrinsic factor namely surface roughness was accounted as affecting the higher optical loss in polyimide siloxane copolymer compared to pure PI. The excellent thermal and optical properties displayed by these series of material established their viable application as waveguide material at 1,550 nm wavelength.
Differential spectroscopic analysis of size‐dependent phycobilisome from Spirulina maxima
Authors: Park Jong Ho , Song Hyeon Gi , Kim Yeon Kyu , Shin Hwa Sung 
Published: June 2020

AbstractC‐phycocyanin (C‐Pc), a photosynthetic pigment for use as a fluorescent indicator or in pharmaceutical, food, and cosmetic products, exists in a phycobilisome complex with allophycocyanin (APC), phycoerythrin (PE), and linker polypeptides. This heterogeneity makes it difficult to quantify phycobilisome composition in an ultraviolet–visible (UV–vis) spectrum. In this study, derivative analysis of UV–vis spectra was successfully applied to display the distinct wavelengths at which C‐Pc, APC, and PE have maximal peaks. In all samples, C‐Pc of the largest portion had a “zero‐crossing” first order, APC did not have a zero‐crossing first order, and PE did not have first derivative for zero crossing or local minimum from the 500 and 700 nm, respectively. The results show that derivative analyses coupled with signal smoothing can be applied to elucidate the composition of phycobilisome under various conditions including purification and environment.
Design‐based mapping of tree attributes by 3P sampling
Authors: Fattorini Lorenzo , Franceschi Sara , Corona Piermaria 
Published: June 2020

AbstractThe estimation of individual values (marks) in a finite population of units (e.g., trees) scattered onto a survey region is considered under 3P sampling. For each unit, the mark is estimated by means of an inverse distance weighting interpolator. Conditions ensuring the design‐based consistency of maps are considered under 3P sampling. A computationally simple mean squared error estimator is adopted. Because 3P sampling involves the prediction of marks for each unit in the population, prediction errors rather than marks can be interpolated. Then, marks are estimated by the predictions plus the interpolated errors. If predictions are good, prediction errors are more smoothed than raw marks so that the procedure is likely to better meet consistency requirements. The purpose of this paper is to provide theoretical and empirical evidence on the effectiveness of the interpolation based on prediction errors to prove that the proposed strategy is a tool of general validity for mapping forest stands.
Direct transpedal pressure measurement during transpedal below‐the‐knee interventions in critical limb ischemia
Authors: Ruzsa Zoltán , Csavajda Ádám , Deák Mónika , Viktor Óriás , Hizoh István , Nemes Balázs , Bertrand Olivier F , Merkely Béla , Kwan Tak W. 
Published: June 2020

AbstractAimThe aim of this study was to assess the feasibility of the distal pressure measurement during transpedal below‐the‐knee interventions in chronic limb‐threatening ischemia (CLTI) and to assess the hemodynamic response after percutaneous transluminal angioplasty.MethodsThe clinical and angiographic data of 137 consecutive patients treated via transpedal access in CLTI (Rutherford 4–6) were evaluated. Distal pedal pressure (PP) at the end of the pedal sheath was measured and the pedal‐to‐aortic pressure index (PAPI) was also calculated before and after the intervention.ResultsGood angiographic results was achieved in 131 patients (95.6%) in the femoro‐popliteal and at least in one below‐the‐knee artery. Significant differences were found in PP and PAPI between before‐ and after‐intervention values (103.2 ± 41.6 mmHg vs. 138.2 ± 37.8 mmHg and 0.74 ± 0.29 vs. 1.03 ± 0.34), respectively. Post‐procedural PP and PAPI were significantly higher in patients who underwent good and borderline/unsuccessful intervention 141.7 [135.8–147.6] versus 82.6 [33.8–131.5] mmHg and 1.05 [1–1.1] versus 0.53 [0.2–0.8], respectively. PP's are significantly different in various Rutherford classification groups. Among the studied parameters, postprocedural PAPI was found to have the best discriminatory power to predict 3‐month amputation (c‐statistic: 0.749, 95% CI: 0.546–0.952, p = .016, sensitivity: 57.1%, specificity: 92.3% using the cut‐off criterion ≤0.58). Major adverse event was detected in 17 patients at 3 months follow up (12.4%), including 7 major amputations (5.1%).ConclusionTranspedal pressure and pedal‐to‐aortic pressure index significantly increased during transpedal below‐the‐knee angioplasty and final pressure and index correlates significantly with limb salvage.
Herbicide resistance in annual bluegrass on Tennessee golf courses
Authors: Brosnan James T. , Vargas Jose J. , Breeden Gregory K. , Zobel John M. 
Published: June 2020

AbstractResearch was conducted to determine the extent of herbicide resistance in annual bluegrass (Poa annua L.) randomly collected from Tennessee golf courses during 2018. Harvested plants were cultured for seed collection, with progeny screened for resistance to glyphosate (Roundup Pro; 32 fl oz acre−1), foramsulfuron (Revolver; 17.4 fl oz acre−1), simazine (Princep 4FL; 2 qt acre−1), or prodiamine (Barricade 65WG; 0.001 mM). In postemergence herbicide screens, annual bluegrass collections were grouped based on survival percentage: resistant (>30% survival), segregating for resistance (5–30% survival), or susceptible (<5% survival). For prodiamine, annual bluegrass collections were screened in hydroponics and deemed resistant when <20% of plants exhibited symptoms of herbicide treatment (e.g., club roots), whereas those with >90% of plants showing symptoms were deemed susceptible; the remainder were intermediate and classified as segregating for resistance. In total, 64% of the annual bluegrass collections had some degree of resistance to glyphosate. Similarly, 21% had some degree of resistance to foramsulfuron, while 58% of annual bluegrass collections had some degree of resistance to prodiamine. Only 3% of the annual bluegrass collections were susceptible to simazine, and 25% of those surviving treatment were resistant to glyphosate or foramsulfuron. Multiple resistance to glyphosate, foramsulfuron, and simazine was reported in 4% of the annual bluegrass collections. The results of this research highlight the need for more diversified weed management strategies to control annual bluegrass on Tennessee golf courses.
Challenges in engineering conductive protein fibres: Disentangling the knowledge
Authors: Roy Sophia , Xie Oliver , Dorval Courchesne Noémie‐Manuelle 
Published: June 2020

AbstractConductive protein materials are promising candidates for next‐generation bioelectronics due to their genetically‐customizable functionalities, biocompatibility, and bioactivity. We envision that they could be used in a variety of bio‐friendly functional devices, including bio‐electronic interfaces, bio‐energy devices, and sensors. However, their practical uses are limited by gaps in our understanding of charge transport in proteins, and by challenges in establishing reliable data collection methods. Moreover, characterization protocols are not always designed with applications in mind, which hinders engineering developments. Here, we review the effects of sample preparation, environmental conditions (ie, hydration level, pH, temperature), measurement scale (nano, micro, and macro), and geometrical considerations, on the measured electrical properties of proteins. We emphasize the need for standardized methods and collaborations across fields for the design of conductive protein materials, keeping in mind their end goal applications. Our objective for this review is to disentangle the knowledge on protein conductivity, and to clarify the current challenges, limitations, and future possibilities for these biological conductors.
Design and practical implementation of verify‐your‐vote protocol
Authors: Chaieb Marwa , Yousfi Souheib , Lafourcade Pascal , Robbana Riadh 
Published: June 2020

SummaryOne of the most critical properties that must be ensured to have a secure electronic voting is verifiability. Political parties, observers, and especially voters want to be able to verify that all eligible votes are cast as intended and counted as cast without compromising votes secrecy or voters privacy. Over the past few decades, an important number of e‐voting protocols attempt to deal with this issue by using cryptographic techniques and/or a public bulletin board. Recently, some blockchain‐based e‐voting systems have been proposed, but were not found practical in the real world, because they do not support situations with large numbers of candidates and voters. In this article, we design and implement a verifiable blockchain‐based online voting protocol, called verify‐your‐vote . Our protocol ensures several security properties thanks to some cryptographic primitives and blockchain technology. We also evaluate its performance in terms of time, cost, and the number of voters and candidates that can be supported.
In‐Plate Quantitative Characterization of Arabidopsis thaliana Susceptibility to the Fungal Vascular Pathogen Fusarium oxysporum
Authors: Huerta Apolonio Ignacio , Kesten Christopher , Menna Alexandra Lauren , Sancho‐Andrés Gloria , Sanchez‐Rodriguez Clara 
Published: June 2020

AbstractRoot vascular pathogens are some of the world's most devastating plant pathogens. However, the methods used to determine plant susceptibility to this class of pathogen are laborious, variable, and in most cases qualitative. Here we present a rapid, simple, and robust infection assay for the characterization of Arabidopsis thaliana resistance to the fungal root pathogen Fusarium oxysporum. The method utilizes fungal root vascular penetrations and fungal‐induced root growth inhibition to deliver a quantitative assessment of plant susceptibility with spatial and temporal resolution. These plant susceptibility indicators are paired with a semiautomated data analysis pipeline to deliver a reproducible assessment of plant susceptibility to root vascular pathogens such as F. oxysporum. © 2020 Wiley Periodicals LLC.Basic Protocol 1: Arabidopsis thaliana plate infection assay using fluorescently labeled Fusarium oxysporumSupport Protocol 1: Preparation of A. thaliana germination platesSupport Protocol 2: Preparation of the F. oxysporum cultureBasic Protocol 2: Data acquisition of F. oxysporum plant infection assaySupport Protocol 3: Acquiring root growth inhibition data using Fiji
Single‐Dose Pharmacokinetics and Pharmacodynamics of Transthyretin Targeting N‐acetylgalactosamine–Small Interfering Ribonucleic Acid Conjugate, Vutrisiran, in Healthy Subjects
Authors: Habtemariam Bahru A. , Karsten Verena , Attarwala Husain , Goel Varun , Melch Megan , Clausen Valerie A. , Garg Pushkal , Vaishnaw Akshay K. , Sweetser Marianne T. , Robbie Gabriel J. , Vest John 
Published: June 2020

Vutrisiran (ALN‐TTRsc02) is a liver‐directed, investigational, small interfering ribonucleic acid drug for the treatment of transthyretin (TTR)‐mediated amyloidosis. This phase I, randomized, single‐blind, placebo‐controlled, single ascending dose study evaluated the pharmacodynamics, pharmacokinetics, and safety profile of subcutaneously administered vutrisiran (5–300 mg) in healthy subjects (n = 80). Vutrisiran treatment achieved potent and sustained TTR reduction in a dose‐dependent manner, with mean maximum TTR reduction of 57–97%, maintained for ≥ 90 days post dose. Vutrisiran was rapidly absorbed (peak plasma concentration 3–5 hours post dose), had a short plasma half‐life (4.2–7.5 hours), and plasma concentrations increased in a dose‐proportional manner. Pharmacodynamic and pharmacokinetic results were similar in Japanese and non‐Japanese subjects. Vutrisiran had an acceptable safety profile; the most common treatment‐related adverse event was mild, transient injection site reactions in four (6.7%) vutrisiran‐treated subjects. The favorable pharmacokinetic, pharmacodynamic, and safety results observed here support vutrisiran's continued clinical development.