bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heterocycles in the Treatment of Neglected Tropical Diseases
Authors: Maheshwari Kush K. , Bandyopadhyay Debasish 
Published: February 2020

Background:
Neglected Tropical Diseases (NTDs) affect a huge population of
the world and the majority of the victims belong to the poor community of the developing
countries. Until now, the World Health Organization (WHO) has identified 20 tropical diseases
as NTDs that must be addressed with high priority. However, many heterocyclic scaffolds
have demonstrated potent therapeutic activity against several NTDs.

Objective:
There are three major objectives: (1) To discuss the causes, symptoms, and current
status of all the 20 NTDs; (2) To explore the available heterocyclic drugs, as well as
their mechanisms of action (if known), that are being used to treat NTDs; (3) To develop
general awareness on NTDs among the medicinal/health research community and beyond.

Methods:
The 20 NTDs have been discussed according to their alphabetic orders along with
the possible heterocyclic remedies. The current status of treatment with an emphasis on the
heterocyclic drugs (commercially available and investigational) has been outlined. In addition,
a brief discussion of the impacts of NTDs on socio-economic conditions is included.

Results:
NTDs are often difficult to diagnose and the problem is worsened by the unhealthy
hygiene, improper awareness, and inadequate healthcare in the developing countries where
these diseases primarily affect poor people. The statistics include the duration of suffering,
the number of individuals affected, and access to healthcare and medication. The mechanisms
of action of various heterocyclic drugs, if reported, have been briefly summarized.

Conclusion:
Scientists and pharmaceutical corporations should allocate more resources to
reveal the in-depth mechanism of action of many heterocyclic drugs that are currently being
used for the treatment of NTDs. Analysis of current heterocyclic compounds and the development
of new medications can help in the fight to reduce/remove the devastating effects of
NTDs. An opinion-based concise review has been presented. Based on the available literature,
this is the first attempt to present all the 20 NTDs and related heterocyclic compounds
under the same umbrella.
Cardiac Repair: The Intricate Crosstalk between the Epicardium and the Myocardium
Authors: Pellegrini Laura , Foglio Eleonora , Pontemezzo Elena , Germani Antonia , Russo Matteo Antonio , Limana Federica 
Published: February 2020

Background:
Substantial evidences support the hypothesis that the epicardium has a role in
cardiac repair and regeneration in part providing, by epithelial to mesenchymal transition (EMT), progenitor
cells that differentiate into cardiac cell types and in part releasing paracrine factors that contribute
to cardiac repair. Besides cell contribution, a significant paracrine communication occurs between
the epicardium and the myocardium that improves the whole regenerative response. Signaling pathways
underlying this communication are multiple as well as soluble factors involved in cardiac repair
and secreted both by myocardial and epicardial cells. Most recently, extracellular vesicles, i.e.
exosomes, that accumulate in the pericardial fluid (PF) and are able to transport bioactive molecules
(cytosolic proteins, mRNAs, miRNAs and other non-coding RNAs), have been also identified as potential
mediators of epicardial-mediated repair following myocardial injury.

Conclusions:
This mini-review provides an overview of the epicardial-myocardial signaling in regulating
cardiac repair in ischemic heart diseases. Indeed, a detailed understanding of the crosstalk between
myocardial and epicardial cells and how paracrine mechanisms are involved in the context of ischemic
heart diseases would be of tremendous help in developing novel therapeutic approaches to promote
cardiomyocytes survival and heart regeneration following myocardial infarction (MI).
Comparison of Benzydamine Hydrochloride Mouthwash 0.15% and Ibuprofen in Reducing Postoperative Pain during 24 hours after Crown Lengthening: a Randomized Clinical Trial
Authors: Khabazian Arezoo , Tavakoli Ali , Soltani Samane , Karami Elaheh , Mohaghegh Niloofar 
Published: February 2020

Background:
Crown lengthening surgery is one of the most common periodontal surgeries. The analgesic effects of benzydamine and ibuprofen tablets have been proven in various studies. The purpose of this study was to compare benzydamine hydrochloride mouthwash 0.15% with ibuprofen in decreasing the pain of patients with crown lengthening surgery who had referred to the Periodontology Department of Yazd Dentistry School in 2015.

Materials & Methods:
In this clinical trial study, 36 patients aged 30 to 60 years who referred to the Periodontal Department of the Dental Faculty of Yazd University of Medical Sciences needing a crown lengthening surgery were randomly allocated to two groups. The patients of the first group were asked to wash their mouth using benzydamine hydrochloride mouthwash 0.15% after the surgery according to the instructed protocol and the patients in the second group were asked to take an ibuprofen tablet (400 mg) every 6 hours. After 24 hours, the level of pain was measured by using the numerical criteria of the Visual Analog Scale (VAS) and the data were analyzed using SPSS software version 18. T test and Mann-Whitney test were used as appropriate.

Results:
77.8% of the participants in the first group had mild pain and rest of the participants had moderate pain. 77.8% of the participants who used ibuprofen tablet reported mild pain, 16.7% had moderate pain and 5.6% had severe pain. The results did not illustrate more effect of ibuprofen on the reduction of pain after crown lengthening surgery compared with benzydamine hydrochloride 0.15% (P=0.48).

Conclusion:
In the present study, there were no changes in the VAS index between the two groups. Therefore, in order to decrease pain after periodontal surgery, benzydamine hydrochloride mouthwash can be widely used as it has fewer side effects, lower price, and similar effects with ibuprofen.

Clinical Trial Registration Code
IRCT2016012312847N2.
Catalytic and Photothermo-catalytic Applications of TiO2-CoOx Composites
Authors: Fiorenza Roberto , Condorelli Marcello , D’Urso Luisa , Compagnini Giuseppe , Bellardita Marianna , Palmisano Leonardo , Scirè Salvatore 
Published: February 2020

Objective:
The necessity to have green and sustainable industrial processes has promoted
new technologies for air and water purification together with the research of new energy sources.
In this contest, the TiO2-based photocatalysis can be considered a promising route for both environmental
applications aIn this work, we have investigated the photocatalytic performance of TiO2-CoOx composites
on both photooxidation and photoreduction reactions. Specifically, we have compared the performance
of the composites in the thermo-catalytic, photo-catalytic and photothermal-catalytic oxidation
of ethanol chosen as model volatile organic compound (VOC) and in the photocatalytic hydrogen
production by simulated solar light from aqueous solution of ethanol.nd hydrogen production through water splitting.

Background:
The necessity to have green and sustainable industrial processes has promoted
new technologies for air and water purification together with the research of new energy sources.
In this contest, the TiO2-based photocatalysis can be considered a promising route for both environmental
applications and hydrogen production through water splitting.

Methods:
The samples were prepared with a simple impregnation method, and were characterized by
Scanning Electron (SEM) and Transmission Electron (TEM) microscopies, X-ray powder diffraction
(XRD), N2 adsorption-desorption measurements, Temperature Programmed Reduction in hydrogen (H2-
TPR) and X-ray Photoelectron (XPS), Raman, UV-Vis Diffuse Reflectance (UV-Vis DRS) and Photoluminescence
(PL) spectroscopies. The catalytic and photocatalytic activity were carried out on pyrex reactors
irradiated with a solar lamp and analyzing the reactions products through gas chromatography.

Results:
The presence and the amount of cobalt oxide were found crucial in determining the performance of
the TiO2-based composites for both the catalytic and photocatalytic processes. In particular, the addition of 1
weight percent of CoOx led to the best performance in the photocatalytic processes, whereas a higher
amount was beneficial in the thermo-catalytic tests. The multi-catalytic approach based on the synergistic
effect of photocatalysis and thermocatalysis in the presence of the TiO2-1%CoOx sample allowed the temperature
necessary to obtain 50% ethanol conversion and 50% yield in CO2 to be reduced by 40°C and
50°C, respectively. The same sample was also the best catalyst for photocatalytic solar H2 production.

Conclusion:
The presence of small amounts of cobalt oxide leads to an efficient composite with TiO2
facilitating the space charge separation and increasing the lifetime of the generated photoholes and
electrons. The wide versatility of TiO2-CoOx catalysts both for photooxidation and photoreduction reactions
motivates to further exploit the use of these systems in real solar-driven photocatalysis.
El caso jesuitas, de El Salvador, en el contexto de la justicia transicional
Authors: Orduña Trujillo Eva Leticia 
Published: February 2020

El artículo tiene el objetivo general de analizar los resultados que el tratamiento del caso jesuitas ha tenido para cada uno de los cuatro ejes que conforman la justicia transicional. En él se realiza una sistematización y análisis de los aspectos tanto nacionales como internacionales más significativos del caso, en cual se identifican también los actores principales que han intervenido. Se ofrece una panorámica integral, con la cual se logran identificar los resultados que el tratamiento del caso han tenido para los cuatro ejes de la justicia transicional, es decir, la verdad, la justicia, las reparaciones y las garantías de no repetición. Las conclusiones a las que se arribaron fueron que en materia de reparaciones y de garantías de no repetición, el tratamiento del caso ha tenido un saldo negativo en su totalidad; mientras que en materia de verdad y de justicia hay resultados mayoritariamente negativos pero también se han registrado algunos positivos. En la sección correspondiente se hace un desglose de los resultados en cada uno de los ejes.
Juana de Ibarborou, Alfonso Reyes y la literatura mexicana en 1929. Amistad literaria y política del espíritu
Authors: Moraes Medina Mariana 
Published: February 2020

Este artículo examina la relación de Juana de Ibarbourou con Alfonso Reyes y la literatura mexicana durante 1929, a partir de la reconstrucción de los intercambios y encuentros que tuvieron lugar entre los escritores durante ese año, en particular, los eventos relacionados con la organización del homenaje a Amado Nervo en Montevideo —en su décimo aniversario luctuoso— y la ceremonia que elevó a la poeta a “Juana de América”. El objetivo del trabajo es analizar, a través de los aportes de la sociología de la literatura, las afinidades, dinámicas de patrocinio literario y transferencia de prestigio entre los autores, y su relación con los proyectos de nación y de cultura promovidos por México y Uruguay a finales de la década de los veinte. Los intercambios iniciales entre Reyes e Ibarbourou (espejo de las lógicas modernistas de promoción y patrocinio patriarcal) colaboraron con la consagración y construcción de la imagen continental de la escritora en 1929 y le aseguraron una aliada de gran notoriedad a la diplomacia cultural del México posrevolucionario en el Río de la Plata. Abstract: This article examines the Uruguayan poet Juana de Ibarbourou’s relationship with Alfonso Reyes by reconstructing the exchanges and meetings that took place between them in 1929, in particular the events related to the organization of a tribute to Amado Nervo in Montevideo on the tenth anniversary of his death and the ceremony that elevated Ibarbourou to “Juana de América”.It does so by analyzing contributions from the sociology of literature, affinities, dynamics of literary sponsorship and transfer of prestige among the authors, and their relationships with their nations and the culture projects promoted in Mexico and Uruguay in the late twenties. The initial exchanges between Reyes and Ibarbourou (a reflection on the modernist logics of patriarchal promotion and sponsorship) helped initiate and construct this writer’s continental image in 1929 and secured an important ally to the cultural diplomacy of post-revolutionary Mexico in the La Plata River region.Key words: Juana de Ibarbourou; Alfonso Reyes; México; Uruguay; Amado Nervo; Sor Juana Inés de la
TINJAUAN SOSIOLOGIS TENTANG PEGADAIAN TERHADAP TANAH PERTANIAN MENURUT UNDANG-UNDANG NOMOR 56 PRP TAHUN1960 (STUDI SENGKETA GADAI TANAH PERTANIAN DI KAMPUNG TINGKEM ASLI DAN TINGKEM BERSATU KECAMATAN BUKIT KABUPATEN BENER MERIAH)
Authors: Seniara Nurdin , Nurdin Ridwan 
Published: February 2020

Gadai ialah suatu yang diperoleh seseorang berpiutang atas suatu barang bergerak yang diserahkan kepadanya oleh seorang berhutang atau oleh seorang yang lain atas namanya, dan yang memberikan kekuasaan kepada orang yang berpiutanguntuk mengambil pelunasan dari barang tersebut, secara didahulukan dari pada orang-orang berpiutang lainnya. Dengan kecualian hanya untuk melelang barang tersebut dan biaya yang telah dikeluarkan untuk menyelamatkan setelah barang itu digadaikan, biaya-biaya mana yang harus didahulukan. Jadi dalam jual gadai terdapat dua pihak, pihak yang menyerahkan tanah, atau pihak pemberi gadai dan pihak kedua adalah pihak menerima tanah atau pihak penerima gadai. Pihak penerima gadai inilah yang harus menyerahkan sejumlah uang tertentu. Perkataan jual menurut hukum adat berarti menyerahkan (over dragen) jadi tidak identik dengan perkataan verkoop dalam bahasa Belanda, dalam perkataan verkoop disinggung pengertian berpindahnya hak milik. Dilain pihak istilah verkoop seolah-olah pihak pertama terikat pada suatu jangka waktu, yang berarti bilamana jangka waktu telah lewat maka pihak kedua menjadi pemilik tanah yang bersangkutan, sedang dalam lembaga jual gadai tidaklah demikian halnya.
Tinjauan Sosiologis Tentang Pegadain Terhadap Tanah Pertanian, Menurut Undang-Undang Nomor 56 Prp Tahun 1960 (Studi Kasus di Kampung Tingkem Asli dan Tingkem Bersatu Kecamatan Bukit Kabupaten Bener Meriah)
Authors: Nurdin Ridwan , Seniara Nurdin 
Published: February 2020

Mengenai pegadaian tanah pertanian yang terjadi di Kecamatan Bukit Kabupaten Bener Meriah yang sering menjadi permasalahan seperti orang yang mengadaikan tanah pertanian sering kehilangan tanahnya, dikarenakan tidak bisa menebusi tanah pertanian yang dia gadaikan. Bagaimana pelaksanaan Gadai Tanah Pertanian di Kampung Tingkem Asli dan Tingkem Bersatu Kecamatan Bukit Kabupaten Bener Meriah setelah berlakunya pasal 7 ayat 1 Undang-undang Nomor 56 Tahun 1960, faktor-faktor apa saja yang menghambat penerapan pasal 7 ayat 1 Undang-undang Nomor 56 Tahun 1960 di Kampung Tingkem Asli dan Tingkem Bersatu Kecamatan Bukit Kabupaten Bener Meriah. Dalam menyusun skripsi ini, penulis menggunakan kajian metode lapangan (field research) dengan menggunakan beberapa teknik yaitu observasi, wawancara dan studi dokumentasi. Data-data yang terkumpul tersebut bersumberkan kepada data primer yaitu data-data yang peneliti peroleh dari lapangan dan data skunder yaitu data-data yang di peroleh dari buku-buku dan karya tulis ilmiah yang mempunyai hubungan dengan masalah yang diteliti. Setelah data terkumpul, kemudian dianalisis dengan menggunakan metode kualitatif. Hasil yang didapat berdasarkan permasalahan yang telah diuraikan berdasarkan tinjauan sosiologis tentang pegadaian tanah pertanian di Kampung Tingkem Asli dan Tingkem Bersatu Kecamatan Bukit Kabupaten Bener Meriah, setelah berlakunya undang-undang pasal 7 (1) nomor 56 tahun 1960, kalangan masyarakat di Kampung Tingkem Asli dan Tingkem Bersatu Kecamatan Bukit Kabupaten Bener Meriah, pelaksanaan Gadai Tanah Pertanian masih menggunakan cara pegadaian secara Hukum Adat. Secara umum menunjukkan bahwa dalam pelaksanaan gadai tanah pertanian masyarakat Kampung Tingkem Asli dan Tingkem Bersatu menyimpang dari ketentuan undang-undang nomor 56 tahun 1960 pasal 7 (1) yang menyinggung mengenai gadai tanah pertanian, dikarenakan masyarakat sudah terbiasa dengan gadai secara hukum adat dalam masyarakat.
Estruturação de elementos formais para implantação de Gestão da Inovação em Bibliotecas
Authors: Silveira Murilo Mauro , Vianna William Barbosa , Cândido Ana Clara , Petri Sérgio Murilo 
Published: February 2020

O objetivo deste estudo é identificar os elementos formais para um modelo multicritério de implantação da gestão da inovação em bibliotecas. Justifica-se pela necessidade de desenvolvimento do tema na Ciência da Informação a partir de elementos relevantes da literatura de maneira geral, aplicados de maneira particular às bibliotecas como unidades de informação com singularidades organizacionais na perspectiva dos bibliotecários. Trata-se de um estudo de natureza qualitativa, construtivista e exploratório com o uso de procedimentos metodológicos da fase de estruturação da Metodologia Multicritério em Apoio à Decisão- Construtivista (MCDA-C). Os resultados apontaram para identificação de oito elementos formais e gerais para o desenvolvimento de modelos de implantação da gestão da inovação em bibliotecas e quarenta e dois indicadores para medir o referido processo.
Uso das novas tecnologias na validação dos conteúdos ministrados durante as aulas
Authors: Silva Cristiano Moreira da , Barbosa Ricardo Rodrigues 
Published: February 2020

As novas tecnologias estão contribuindo de forma ampla para inserção de mudanças significativas na sociedade em geral, alterando a forma como interagimos com as coisas e com as pessoas. No ramo educacional, essas modificações contribuíram para substanciais mudanças na forma de ensinar, e agora existe a possibilidade de os alunos validarem o conteúdo ministrado em sala de aula. Diante do exposto, o presente estudo buscou responder à seguinte indagação: Quais as percepções dos discentes do Curso de Ciências Contábeis sobre o hábito da validação do conteúdo ministrado em aulas, com o uso das novas ferramentas tecnológicas disponíveis? A pesquisa é classificada como descritiva, de levantamento e predominantemente quantitativa. Através da adoção de Survey, obtiveram-se 209 respostas válidas dos discentes do Curso Superior de Ciências Contábeis, com as quais foi possível verificar que grande parte dos entrevistados reconhece que possuem o hábito de validação do conteúdo ministrado em aulas através das novas tecnologias. Além disso, foi possível observar que grande parte dos entrevistados considera a tecnologia neutra, contudo, ainda segundo a visão deles, ela não é difundida de forma democrática.
Mutações na ciência da informação e reflexos nas mandalas interdisciplinares
Authors: Pinheiro Lena Vania Ribeiro 
Published: February 2020

Pesquisa sobre a constituição epistemológica da Ciência da Informação, suas transformações ao longo do seu desenvolvimento e sua representação em mandalas, a fim de traçar uma nova configuração que espelhe a área na contemporaneidade. O método adotado reuniu o qualitativo e quantitativo, tanto por mapeamentos da literatura quanto por metrias da informação e comunicação. A epistemologia e a interdisciplinaridade sustentaram teoricamente a pesquisa e diferentes fontes foram utilizadas, do Brasil e do exterior. Os resultados demonstram que a Ciência da informação estudada e praticada no Brasil está de acordo com a agenda internacional de pesquisas da área, com exceção da divulgação científica observada e justificada pelas políticas públicas e ações de informação de nosso país. O traçado atual da mandala representativa da Ciência da Informação no mundo de hoje possibilitou estabelecer novas fases. A atual é manifestada pela Ciência Aberta e Ciência Cidadã que, por sua vez, expressam a aproximação de Ciência e sociedade, em processo de reconhecimento do direto de todos à informação e ao conhecimento.
Encontrabilidade e teoria da intencionalidade: propriedades para a informação
Authors: Miranda Májory Karoline 
Published: February 2020

A pesquisa discute encontrabilidade de informação a partir do mapeamento das propriedades do fenômeno informacional, com destaque para a Teoria da Intencionalidade, inerente aos estudos da Fenomenologia, e para as muitas definições de informação atuantes na Ciência da Informação (CI). O método dos quatro pólos congrega as etapas Epistemológica, Teórica, Técnica e Morfológica que sustentam, respectivamente, a natureza do problema, as teorias como estratégia, a técnica bibliográfica e descritiva, e a morfológica com os resultados e interpretação da noção de informação enquanto fenômeno, a partir da Teoria da Intencionalidade, ou seja as propriedades. Contribuindo com o esforço de conceituação uniforme da informação, os resultados inferem suas propriedades de: Intencionalidade/direccionalidade; atos de fala assertivo e diretivo; direção de ajustamento; e rede e background. O estudo foi inicialmente desenvolvido em tese de doutoramento, e posteriormente continuado como projeto de pesquisa e discutido no grupo Estudos Epistemológicos em Informação do Departamento de Ciência da Informação da Universidade Federal de Pernambuco. Palavras-chave: Teoria da Intencionalidade; fenômeno informacional; propriedades de informação.
Rede de cooperação científica de co-autorias entre pesquisadores e bolsistas de iniciação científica
Authors: Gomes Gusttavo Nunes , Sousa Marcos de Moraes , Soares Andressa Viana , Cardoso Flávio Manoel Coelho Borges 
Published: February 2020

A cooperação entre pesquisadores experientes e alunos de iniciação científica é um meio de formação de novos pesquisadores e profissionais e trata-se também de um meio relevante de difusão de conhecimento. O estudo teve por objetivo avaliar a rede social de cooperação científica de coautorias entre pesquisadores e bolsistas de iniciação científica. Foi utilizado como lócus de pesquisa o Instituto Federal Goiano Campus Ceres. Foi realizada análise documental: (i) na base de dados dos currículos lattes dos autores, e; (ii) nos documentos e relatórios de comitês de pesquisa da organização. Os resultados apresentam a topologia e medidas da rede de publicações. Os resultados apontam para um crescente envolvimento da área de computação, principalmente com a recém implementação da graduação em Sistemas de Informação, tendo em vista que o campus possui tradição e foco em ciências agrárias, a área de computação teve uma produção científica equiparada a cursos mais antigos e já consolidados no campus, indicando o potencial de interdisciplinaridade e de pesquisas conjuntas.