bluuebunny/crossref_metadata_2025_split huggingface dataset:
A-07 The Impact of Learning Disorders on Clinical Measures Following Concussion
Authors: Carpenter C M , Zynda A J , Stokes M A , Chung J S , Cullum C M , Miller S M 
Published: June 2020

Abstract

Objective
To examine differences in clinical measures between adolescents with dyslexia, ADD/ADHD, and those without a learning disorder (LD) following concussion.

Method
Data from the North Texas Concussion Registry (ConTex) were extracted. Participants ages 10–18 with a diagnosed concussion within 30 days of enrollment were included and categorized based on self-reported prior diagnosis of dyslexia, ADD/ADHD, and no history of LD. ImPACT, King-Devick (KD), SCAT-5 symptom log, Patient Health Questionnaire (PHQ-8), and Generalized Anxiety Disorder (GAD-7) scale were compared between groups using a one-way ANOVA followed by a Tukey test for multiple comparisons.

Results
Of 993 eligible participants, 68 had dyslexia, 141 had ADD/ADHD, and 784 had no history of LD. There were significantly more male participants in the ADD/ADHD group compared to the no LD group (64.5% vs. 50.3%, p = 0.002). No other demographic differences were noted between groups. In the dyslexia group, SCAT-5 symptom score was higher (36.22 vs. 28.27, p = 0.037) and ImPACT visual motor control was lower compared to the no LD group (28.87 vs. 32.99, p = 0.027). In the ADD/ADHD group, ImPACT symptom score was higher (30.69 vs. 20.94, p &lt; 0.001) and visual motor control was lower compared to the no LD group (30.05 vs. 32.99, p = 0.009). KD time (62.1 sec), PHQ-8 (5.79), and GAD-7 (5.06) were higher in the ADD/ADHD group compared to the no LD group (56.5 sec, 4.32, 3.56; p = 0.022, p = 0.003, p = 0.002).

Conclusions
Differences in clinical measures were seen in participants with a history of dyslexia and ADD/ADHD that may aid providers in their evaluation following adolescent concussion.
A-49 To Nap or Not to Nap? The Influence of Napping on Recovery Outcomes Following Concussion
Authors: Zynda A J , Petit K M , Anderson M , Tomczyk C P , Covassin T 
Published: June 2020

Abstract

Objective
To determine the influence of nap frequency on daily symptom severity and recovery time following concussion in college students.

Method
A prospective study of college students within 72 hours of a diagnosed concussion was performed. Participants reported nap occurrence (yes/no) and daily concussion symptoms using the Post-Concussion Symptom Scale (PCSS) for six days. Participants were categorized into frequent (&gt;2 naps) and infrequent (&lt;3 naps) nap groups. Recovery time was defined as total days from injury to unrestricted medical clearance. A mixed between-within ANOVA evaluated changes in daily symptom severity between nap groups, while Spearman’s Rank Correlation assessed the relationship between the number of days napping and recovery time.

Results
Thirty-four participants (23 female, 11 male; age = 19.91 ± 1.38 years) were included, with 22 in the infrequent nap group and 12 in the frequent nap group. Average recovery time for the infrequent nap group was 13.85 days compared to 18.8 days in the frequent nap group. There was no significant group x time interaction for daily symptom severity (Wilks’ λ = 0.85, F(5,24) = 0.85, p = 0.53, η2 = 0.15). There was a significant main effect for time, with daily symptom severity improving following concussion (Wilks’ λ = 0.31, F(5,24) = 10.66, p &lt; 0.001, η2 = 0.69), but there was no significant group effect (F(1,28) = 0.79, p = 0.38, η2 = 0.03). Overall, the more naps taken, the longer the recovery time (Rs = 0.46, p = 0.01).

Conclusions
Findings from the present study suggest that frequent napping does not affect symptom severity following concussion. Further research is needed to elucidate the association between the number of naps and recovery time.
Group Lies and Reflections on the Purpose of Social Epistemology
Authors: Bright Liam Kofi 
Published: June 2020

Abstract
Jennifer Lackey (2020) makes the case that non-summativist accounts of group belief cannot adequately account for an important difference between group lies (or, separately, group bullshit) and group belief. Since non-summativist accounts fail to do this, she argues that they ought be rejected and that we should seek an account of group belief which can do better by this standard. I briefly summarize Lackey’s argument, to give a sense of the role I see the central desideratum playing, and outline her arguments for that desideratum. I then critique one of the positive arguments she offers for the desideratum, briefly outlining the notion of explication and why I think it would not license the appeal to the Group Lie Desideratum that Lackey’s argument depends upon. This leads me to reflections on the broader project of analysing notions of group belief, and the role I think such endeavours can or ought to play in social epistemology more broadly.
Juvenile social dynamics reflect adult reproductive strategies in bottlenose dolphins
Authors: Galezo Allison A , Foroughirad Vivienne , Krzyszczyk Ewa , Frère Céline H , Mann Janet 
Published: June 2020

AbstractThe juvenile period is a challenging life-history stage, especially in species with a high degree of fission–fusion dynamics, such as bottlenose dolphins, where maternal protection is virtually absent. Here, we examined how juvenile male and female bottlenose dolphins navigate this vulnerable period. Specifically, we examined their grouping patterns, activity budget, network dynamics, and social associations in the absence of adults. We found that juveniles live in highly dynamic groups, with group composition changing every 10 min on average. Groups were generally segregated by sex, and segregation was driven by same-sex preference rather than opposite-sex avoidance. Juveniles formed strong associations with select individuals, especially kin and same-sex partners, and both sexes formed cliques with their preferred partners. Sex-specific strategies in the juvenile period reflected adult reproductive strategies, in which the exploration of potential social partners may be more important for males (which form long-term alliances in adulthood) than females (which preferentially associate with kin in adulthood). Females spent more time alone and were more focused on foraging than males, but still formed close same-sex associations, especially with kin. Males cast a wider social net than females, with strong same-sex associations and many male associates. Males engaged in more affiliative behavior than females. These results are consistent with the social bonds and skills hypothesis and suggest that delayed sexual maturity in species with relational social complexity may allow individuals to assess potential associates and explore a complex social landscape without the risks associated with sexual maturity (e.g., adult reproductive competition; inbreeding).
Integrative, normalization-insusceptible statistical analysis of RNA-Seq data, with improved differential expression and unbiased downstream functional analysis
Authors: Fanidis Dionysios , Moulos Panagiotis 
Published: June 2020

Abstract
The study of differential gene expression patterns through RNA-Seq comprises a routine task in the daily lives of molecular bioscientists, who produce vast amounts of data requiring proper management and analysis. Despite widespread use, there are still no widely accepted golden standards for the normalization and statistical analysis of RNA-Seq data, and critical biases, such as gene lengths and problems in the detection of certain types of molecules, remain largely unaddressed. Stimulated by these unmet needs and the lack of in-depth research into the potential of combinatorial methods to enhance the analysis of differential gene expression, we had previously introduced the PANDORA P-value combination algorithm while presenting evidence for PANDORA’s superior performance in optimizing the tradeoff between precision and sensitivity. In this article, we present the next generation of the algorithm along with a more in-depth investigation of its capabilities to effectively analyze RNA-Seq data. In particular, we show that PANDORA-reported lists of differentially expressed genes are unaffected by biases introduced by different normalization methods, while, at the same time, they comprise a reliable input option for downstream pathway analysis. Additionally, PANDORA outperforms other methods in detecting differential expression patterns in certain transcript types, including long non-coding RNAs.
A survey on predicting microbe-disease associations: biological data and computational methods
Authors: Wen Zhongqi , Yan Cheng , Duan Guihua , Li Suning , Wu Fang-Xiang , Wang Jianxin 
Published: June 2020

AbstractVarious microbes have proved to be closely related to the pathogenesis of human diseases. While many computational methods for predicting human microbe-disease associations (MDAs) have been developed, few systematic reviews on these methods have been reported. In this study, we provide a comprehensive overview of the existing methods. Firstly, we introduce the data used in existing MDA prediction methods. Secondly, we classify those methods into different categories by their nature and describe their algorithms and strategies in detail. Next, experimental evaluations are conducted on representative methods using different similarity data and calculation methods to compare their prediction performances. Based on the principles of computational methods and experimental results, we discuss the advantages and disadvantages of those methods and propose suggestions for the improvement of prediction performances. Considering the problems of the MDA prediction at present stage, we discuss future work from three perspectives including data, methods and formulations at the end.
The ontogeny of sea turtle hatchling swimming performance
Authors: Gatto Christopher R , Reina Richard D 
Published: June 2020

AbstractSea turtle hatchlings experience high mortality rates during dispersal. To minimize time spent in predator-dense waters, hatchlings typically undergo a period of hyperactivity termed the ‘frenzy’, characterized by almost continuous swimming for ~24 h. Research has focused on swimming performance during the frenzy, but our understanding of changes in swimming performance post-frenzy is limited. Thus, we measured green turtle (Chelonia mydas) hatchling swimming performance during the frenzy and post-frenzy when the turtles were 4, 12 and 24 weeks old. Using load cells, we recorded thrust production, stroke rates and the time turtles spent performing various swimming gaits. We found that the proportion of time spent powerstroking and the thrust generation per powerstroke were the main determinants of overall swimming performance. Older, larger turtles generated more thrust per stroke, but the proportion of time spent powerstroking throughout the entire swimming trial did not differ among age groups. Hatchlings have been thought mainly to use currents to reach nursery foraging grounds, and our findings suggest that hatchling swimming might also play an important role in directing hatchlings to optimal nursery habitats, supporting recent studies. Additionally, turtle size is positively related to swimming performance in post-frenzy turtles, suggesting that faster-growing turtles might have fitness advantages over slower-growing turtles.
Use of Baricitinib in Patients With Moderate to Severe Coronavirus Disease 2019
Authors: Titanji Boghuma K , Farley Monica M , Mehta Ashish , Connor-Schuler Randi , Moanna Abeer , Cribbs Sushma K , O’Shea Jesse , DeSilva Kathryn , Chan Bonnie , Edwards Alex , Gavegnano Christina , Schinazi Raymond F , Marconi Vincent C 
Published: June 2020

Abstract
Hyperinflammation is associated with increased mortality in coronavirus disease 2019 (COVID-19). In this retrospective, uncontrolled patient cohort with moderate -severe COVID-19, treatment with baricitinib plus hydroxychloroquine was associated with recovery in 11 of 15 patients. Baricitinib for the treatment of COVID-19 should be further investigated in randomized, controlled clinical trials.
Long-term outcomes after transcatheter aortic valve implantation in failed bioprosthetic valves
Authors: Bleiziffer Sabine , Simonato Matheus , Webb John G , Rodés-Cabau Josep , Pibarot Philippe , Kornowski Ran , Windecker Stephan , Erlebach Magdalena , Duncan Alison , Seiffert Moritz , Unbehaun Axel , Frerker Christian , Conzelmann Lars , Wijeysundera Harindra , Kim Won-Keun , Montorfano Matteo , Latib Azeem , Tchetche Didier , Allali Abdelhakim , Abdel-Wahab Mohamed , Orvin Katia , Stortecky Stefan , Nissen Henrik , Holzamer Andreas , Urena Marina , Testa Luca , Agrifoglio Marco , Whisenant Brian , Sathananthan Janarthanan , Napodano Massimo , Landi Antonio , Fiorina Claudia , Zittermann Armin , Veulemans Verena , Sinning Jan-Malte , Saia Francesco , Brecker Stephen , Presbitero Patrizia , De Backer Ole , Søndergaard Lars , Bruschi Giuseppe , Franco Luis Nombela , Petronio Anna Sonia , Barbanti Marco , Cerillo Alfredo , Spargias Konstantinos , Schofer Joachim , Cohen Mauricio , Muñoz-Garcia Antonio , Finkelstein Ariel , Adam Matti , Serra Vicenç , Teles Rui Campante , Champagnac Didier , Iadanza Alessandro , Chodor Piotr , Eggebrecht Holger , Welsh Robert , Caixeta Adriano , Salizzoni Stefano , Dager Antonio , Auffret Vincent , Cheema Asim , Ubben Timm , Ancona Marco , Rudolph Tanja , Gummert Jan , Tseng Elaine , Noble Stephane , Bunc Matjaz , Roberts David , Kass Malek , Gupta Anuj , Leon Martin B , Dvir Danny 
Published: June 2020

Abstract

Aims
Due to bioprosthetic valve degeneration, aortic valve-in-valve (ViV) procedures are increasingly performed. There are no data on long-term outcomes after aortic ViV. Our aim was to perform a large-scale assessment of long-term survival and reintervention after aortic ViV.

Methods and results
A total of 1006 aortic ViV procedures performed more than 5 years ago [mean age 77.7 ± 9.7 years; 58.8% male; median STS-PROM score 7.3% (4.2–12.0)] were included in the analysis. Patients were treated with Medtronic self-expandable valves (CoreValve/Evolut, Medtronic Inc., Minneapolis, MN, USA) (n = 523, 52.0%), Edwards balloon-expandable valves (EBEV, SAPIEN/SAPIEN XT/SAPIEN 3, Edwards Lifesciences, Irvine, CA, USA) (n = 435, 43.2%), and other devices (n = 48, 4.8%). Survival was lower at 8 years in patients with small-failed bioprostheses [internal diameter (ID) ≤ 20 mm] compared with those with large-failed bioprostheses (ID &gt; 20 mm) (33.2% vs. 40.5%, P = 0.01). Independent correlates for mortality included smaller-failed bioprosthetic valves [hazard ratio (HR) 1.07 (95% confidence interval (CI) 1.02–1.13)], age [HR 1.21 (95% CI 1.01–1.45)], and non-transfemoral access [HR 1.43 (95% CI 1.11–1.84)]. There were 40 reinterventions after ViV. Independent correlates for all-cause reintervention included pre-existing severe prosthesis–patient mismatch [subhazard ratio (SHR) 4.34 (95% CI 1.31–14.39)], device malposition [SHR 3.75 (95% CI 1.36–10.35)], EBEV [SHR 3.34 (95% CI 1.26–8.85)], and age [SHR 0.59 (95% CI 0.44–0.78)].

Conclusions
The size of the original failed valve may influence long-term mortality, and the type of the transcatheter valve may influence the need for reintervention after aortic ViV.
Purchases of psychotropic drugs among the migrant population in Finland: a nationwide register-based cohort study
Authors: Lehti Venla , Suvisaari Jaana , Gissler Mika , Markkula Niina 
Published: June 2020

Abstract

Background
Migrant populations may have different mental health service needs when compared with native populations. One indicator of service use is the use of psychotropic medication. The aim of this study was to compare the purchases of psychotropic drugs among different migrant populations with the native population in Finland.

Methods
Foreign-born participants (n = 184 805) and their Finnish-born controls (n = 185 183) were identified from the Finnish Central Population Register. Information on their purchases of psychotropic drugs in 2011–15 was collected from the National Prescription Register. A washout period of 2009–10 was used to define incident purchases. Cox regression analysis was the statistical method used.

Results
At least one incident purchase of a psychotropic drug was identified for 11.1% of migrant women, 11.4% of Finnish-born women, 8.7% of migrant men and 9.8% of Finnish-born men. When controlled for age, sex, marital status, socioeconomic status and social assistance, migrants were less likely to purchase psychotropic drugs (adjusted hazard ratio 0.96, 95% confidence interval 0.93–0.98), but there was variation between different drug categories. Recent migrants and migrants from Asia and Sub-Saharan Africa were least likely to purchase drugs. Migrants from Nordic countries and other Western countries most closely resembled the Finnish-born controls.

Conclusions
Recent migrants in Finland appear to use fewer psychotropic drugs than native Finns. It is important to analyze the reasons for this pattern, as they may indicate delays in access to care or benefits. The heterogeneity of migrant populations must also be considered when developing services to better address their needs.
Insights into dryland biocrust microbiome: geography, soil depth and crust type affect biocrust microbial communities and networks in Mojave Desert, USA
Authors: Pombubpa Nuttapon , Pietrasiak Nicole , De Ley Paul , Stajich Jason E 
Published: June 2020

ABSTRACT
Biocrusts are the living skin of drylands, comprising diverse microbial communities that are essential to desert ecosystems. Despite there being extensive knowledge on biocrust ecosystem functions and lichen and moss biodiversity, little is known about factors structuring diversity among their microbial communities. We used amplicon-based metabarcode sequencing to survey microbial communities from biocrust surface and subsurface soils at four sites located within the Mojave Desert. Five biocrust types were examined: Light-algal/Cyanobacteria, Cyanolichen, Green-algal lichen, Smooth-moss and Rough-moss crust types. Microbial diversity in biocrusts was structured by several characteristics: (i) central versus southern Mojave sites displayed different community signatures, (ii) indicator taxa of plant-associated fungi (plant pathogens and wood saprotrophs) were identified at each site, (iii) surface and subsurface microbial communities were distinct and (iv) crust types had distinct indicator taxa. Network analysis ranked bacteria–bacteria interactions as the most connected of all within-domain and cross-domain interaction networks in biocrust surface samples. Actinobacteria, Proteobacteria, Cyanobacteria and Ascomycota functioned as hubs among all phyla. The bacteria Pseudonocardia sp. (Pseudonocardiales, Actinobacteria) and fungus Alternaria sp. (Pleosporales, Ascomycota) were the most connected had the highest node degree. Our findings provide crucial insights for dryland microbial community ecology, conservation and sustainable management.
The bacterioplankton community composition and a host genotype dependent occurrence of taxa shape the Daphnia magna gut bacterial community
Authors: Callens Martijn , De Meester Luc , Muylaert Koenraad , Mukherjee Shinjini , Decaestecker Ellen 
Published: June 2020

ABSTRACT
The assembly of host-associated bacterial communities is influenced by a multitude of biotic and abiotic factors. It is essential to gain insight in the impact and relative strength of these factors if we want to be able to predict the effects of environmental change on the assembly of host-associated bacterial communities, or deliberately modify them. The environmental pool of bacteria, from which the host is colonized, and the genetic background of the host are both considered to be important in determining the composition of host-associated bacterial communities. We experimentally assessed the relative importance of these two factors and their interaction on the composition of Daphnia magna gut bacterial communities. Bacterioplankton originating from natural ponds or a laboratory culture were used to inoculate germ-free Daphnia of different genotypes. We found that the composition of the environmental bacterial community has a major influence on the Daphnia gut bacterial community, both reflected by the presence or absence of specific taxa as well as by a correlation between abundances in the environment and on the host. Our data also indicate a consistent effect of host genotype on the occurrence of specific bacterial taxa in the gut of Daphnia over different environments.
Nutrient enrichment increases size of Zostera marina shoots and enriches for sulfur and nitrogen cycling bacteria in root-associated microbiomes
Authors: Wang Lu , Tomas Fiona , Mueller Ryan S 
Published: June 2020

ABSTRACTSeagrasses are vital coastal ecosystem engineers, which are mutualistically associated with microbial communities that contribute to the ecosystem services provided by meadows. The seagrass microbiome and sediment microbiota play vital roles in belowground biogeochemical and carbon cycling. These activities are influenced by nutrient, carbon and oxygen availability, all of which are modulated by environmental factors and plant physiology. Seagrass meadows are increasingly threatened by nutrient pollution, and it is unknown how the seagrass microbiome will respond to this stressor. We investigated the effects of fertilization on the physiology, morphology and microbiome of eelgrass (Zostera marina) cultivated over 4 weeks in mesocosms. We analyzed the community structure associated with eelgrass leaf, root and rhizosphere microbiomes, and of communities from water column and bulk sediment using 16S rRNA amplicon sequencing. Fertilization led to a higher number of leaves compared with that of eelgrass kept under ambient conditions. Additionally, fertilization led to enrichment of sulfur and nitrogen bacteria in belowground communities. These results suggest nutrient enrichment can stimulate belowground biogeochemical cycling, potentially exacerbating sulfide toxicity in sediments and decreasing future carbon sequestration stocks.
Differences in the expression of cell envelope proteinases (CEP) in two Lactobacillus paracasei probiotic strains
Authors: Coll-Marqués José María , Bäuerl Christine , Zúñiga Manuel , Pérez-Martínez Gaspar 
Published: June 2020

ABSTRACT
Proteinase PrtP (EC:3.4.21.96) is a cell envelope proteinase (CEP) highly expressed in the probiotic strain Lactobacillus paracasei BL312(VSL#3) that accounts for its anti-inflammatory properties. The main aim of this work is to understand differences in CEP expression between this strain and L. paracasei BL23. Hence, differences in the regulation by amino acid sources of four proteinase related genes (prtP, prsA, prtR1 and prtR2) were determined by RT-qPCR in BL312(VSL#3) and BL23 using as a reference BL368, a BL23 derepressed mutant lacking the response regulator (RR) PrcR. BL312(VSL#3) showed greater expression of prtP (2- to 3-fold) than BL23, and prtP was highly repressed by peptone in both strains. Two other putative CEP genes, prtR1 and prtR2, showed a low expression profile. Interestingly, when the prsA-prtP promoter region from both strains, and deleted mutants, were cloned in vector pT1GR, expression of the gfp and mrfp fluorescent reporters was always repressed in BL23 (high or low peptone) and derepressed in BL368, revealing an interesting mechanism of regulation affecting specifically to this promoter. In conclusion, BL312(VSL#3) has higher expression of prtP and other CEP related genes than BL23, that could respond to a natural deregulation in this strain, possibly independent from the RR PrcR.