bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parent-perceived barriers to accessing services for their child’s mental health problems.
Authors: Hansen Anna Sofie , Telléus Gry Kjaersdam , Mohr-Jensen Christina , Lauritsen Marlene Briciet 
Published: December 2020

Abstract
Background: Many children and adolescents with impairing mental health disorders are not in contact with specialized child and adolescent mental health services (CAMHS). In order to close the service gap, it is important to increase our knowledge of barriers to access. The aim of this study was to investigate parent perceived barriers to accessing services for their child’s mental health problems to identify potential areas for improvement of access to CAMHS. Method: In this cross-sectional observational study 244 parents of children and adolescents referred to outpatient psychiatric assessment were interviewed using the Children’s services interview regarding barriers to accessing child mental health services across healthcare, educational services and social services. Parent reported barriers were analyzed in relation to the child’s age, referral reason, symptom duration and impairment of the child. Results: The most commonly reported barriers were lack of information about were to seek help (60.3%), the perception that professionals did not listen (59.8%) and professionals refusing to initiate interventions or provide referral to services (53.7%). Lack of knowledge, stigmatization and unavailability of services were common themes across barriers to help-seeking. Long symptom duration and parent rated impairment was associated with increased risk of reporting several barriers to help-seeking. Conclusion: Parents seeking help for their child’s mental health encounter numerous barriers that could explain part of the treatment gap and long duration of mental health problems in children prior to referral to CAMHS.
Lnc-GULP1-2:1 affects granulosa cell proliferation by regulating COL3A1 expression and localization​
Authors: Yao Guidong , Kong Yue , Yang Guang , Kong Deqi , Xu Yijiang , He Jiahuan , Xu Ziwen , Bai Yucheng , Fan Huiying , He Qina , Sun Yingpu 
Published: December 2020

Abstract
Backgrounds: Long non-coding RNA is a kind of RNA molecule with a transcript length of more than 200 nt and lacking protein coding ability. Recent studies have found that it is widely involved in many pathological and physiological processes. In our previous study, we found that lnc-GULP1-2:1 was significantly down-regulated in the ovarian cortical tissue of patients with primary ovarian insufficiency and predicted that lnc-GULP1-2:1 has a regulatory effect on COL3A1. Results: In this study, we found that lnc-GULP1-2:1 was mainly localized in the cytoplasm of luteinized granulosa cells and was lower expressed in patients with diminished ovarian reserve but highly expressed in patients with polycystic ovary syndrome. Overexpression of lnc-GULP1-2:1 in KGN cells significantly inhibited cell proliferation, which may be related to the regulation of cell cycle related genes CCND2 and p16. To further investigate the regulation of lnc-GULP1-2:1 on COL3A1, RNA analysis revealed a positive correlation between the expression of lnc-GULP1-2:1 and COL3A1 in multiple cell lines, and this was consistent in luteinized granulosa cells from patients with different ovarian functions. We also found that overexpression of lnc-GULP1-2:1 in KGN cells promoted the expression and migration of COL3A1 into the nucleus, and silencing COL3A1 gene in KGN cells also significantly inhibited cell proliferation. Conclusions: Lnc-GULP1-2:1 affects the proliferation of granulosa cells by regulating the expression and localization of COL3A1 protein, and may participate in the regulation of ovarian follicle development. This study will provide a new idea for understanding the regulatory mechanism of follicular development and a new strategy for the diagnosis and treatment of diseases related to ovarian follicular development disorders in the future.
Impact of treating iron deficiency, diagnosed according to hepcidin quantification, on outcomes after a prolonged ICU stay compared to standard care: a multicenter, randomized, single-blinded trial.
Authors: lasocki sigismond , ASFAR Pierre , JABER Samir , FERRANDIERE Martine , KERFORNE Thomas , ASEHNOUNE Karim , MONTRAVERS Philippe , SEGUIN Philippe , PEOC’H Katell , GERGAUD Soizic , NAGOT Nicolas , LEFEBVRE Thibaud , Lehmann Sylvain , group HEPCIDAN Study 
Published: December 2020

Abstract
Background: Anemia is a significant problem in patients on ICU. Its commonest cause, iron deficiency (ID), is difficult to diagnosed in the context of inflammation. Hepcidin is a new marker of ID. We aimed to assess whether hepcidin levels would accurately guide treatment of ID in critically ill anemic patients after a prolonged ICU stay and affect the post-ICU outcomes. Methods: In a controlled, single-blinded, multicenter study, anemic (WHO definition) critically ill patients with an ICU stay ≥5 days were randomized when discharge was expected to either intervention by hepcidin treatment protocol or control. In the intervention arm patients were treated with intravenous iron (1g of ferric carboxymaltose) when hepcidin was <20 μg/l and with intravenous iron and erythropoietin for 20≤ hepcidin <41 μg/l. Control patients were treated according to standard care (hepcidin quantification remained blinded). Primary endpoint was the number of days spent in hospital 90 days after ICU discharge (post-ICU LOS). Secondary endpoints were day 15 anemia, day 30 fatigue, day-90 mortality and one-year survival. Results: Of 405 randomized patients, 399 were analyzed (201 in intervention and 198 in control arm). 220(55%) had ID at discharge (i.e. an hepcidin <41 μg/l). Primary endpoint was not different (medians(IQR) post-ICU LOS 33(13;90) vs33(11;90) days for intervention and control respectively, median difference -1(-3;1) days, p=0.78). D90 mortality was significantly lower in intervention arm (16(8%) vs 33(16.6%) deaths, absolute risk difference -8.7 (-15.1 to -2.3)%, p=0.008, OR 95%IC, 0.46, 0.22 to 0.94, p=0.035) and one-year survival was improved (p =0.04). Conclusion: Treatment of ID diagnosed according to hepcidin levels did not reduce the post-ICU LOS, but was associated with a significant reduction in D90 mortality and with improved 1-year survival in critically ill patients about to be discharged after a prolonged stay.
Association between exposure to drinking water disinfection byproducts and adverse pregnancy outcomes in South Africa
Authors: Mashau Funanani , Ncube Esper Jacobeth , Voyi Kuku 
Published: December 2020

Abstract
Currently, there is contradictory evidence for the risk of adverse pregnancy outcomes associated with maternal exposure to disinfection byproducts (DBPs). We examine the association between maternal exposure to trihalomethanes (THMs) in drinking water and adverse pregnancy outcomes, including premature birth, low birth weight (LBW) and small for gestational age (SGA). In total, 1,167 women older than 18 years were enrolled at public antenatal venues in two geographical districts. For each district, we measured the levels of residential drinking water DBPs (measured in THMs) through regulatory data and routine water sampling. We estimated the individual uptake of water of each woman by combining individual water use and uptake factors. Increased daily internal dose of total THMs during the third trimester of pregnancy significantly increased the risk of delivering premature infants (AOR 3.13, 95% CI 1.36–7.17). The risk of premature birth was also positiviely associated with exposure to total THMs during the whole pregnancy (AOR 2.89, 95% CI 1.25–6.68). The risk of delivering an SGA and LBW infant was not associated with maternal exposure to THMs. Our findings suggest that exposure to THMs is associated with certain negative pregnancy outcomes. The levels of THMs in water should be routinely monitored.
Evaluating the policy of listening to customer claims in a drinking water utility using fuzzy-AHP approach and WASPAS method
Authors: Bouchraki Faiza , Berreksi Ali , Hamchaoui Samir 
Published: December 2020

Abstract
The objective of this work is to develop a decision support methodology intended for drinking water utility managers in order to support them in the challenge of achieving better performance in the management of the customer area. This methodology requires the prior collection of data for the identification of registered claims. Subsequently, an evaluation of the performance of the customer area defined by the objective ‘Better listening to customer claims’ will be carried out; this requires the structuring of the objective in a hierarchy based on indicators and the adoption of two adequate decision support tools, a fuzzy-AHP for weighting the elements and WASPAS for calculating the performance of the objective. An application is carried out on the water utility of the Wilaya of Bejaia (Algeria). The data collection enabled the identification of 19 types of claims divided into three aspects. The combination of fuzzy-AHP and WASPAS allowed assessment of the performance of the objective during the period 2014–2018 and to make a judgment on the national policy established. The results are satisfactory. Progress has been made in claims management, but the major difficulty lies in the claims processing relating to the quantitative aspect.
Integrated UPLC-MS/MS and UHPLC-Q-orbitrap HRMS Analysis to Reveal Pharmacokinetics and Metabolism of Five Terpenoids from Alpiniae oxyphyllae Fructus in Rats
Authors: Zuo Lihua , Li Jia , Xue Lianping , Jia Qingquan , Li Zhuolun , Zhang Mengya , Zhao Mengfan , Wang Mengli , Kang Jian , Du Shuzhang , Sun Zhi 
Published: December 2020

Background:Alpiniae oxyphyllae Fructus (AOF), a traditional Chinese medicine (TCM), is widely used in the treatment of urinary, gastrointestinal and neurologic diseases in China. Although terpenoids are the main active ingredients of AOF, there are few researches on their pharmacokinetics and metabolism.Methods:In this study, a sensitive, rapid, accurate and novel ultra high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was established to evaluate the pharmacokinetic behavior of five terpenoids (oxyphyllenodiol B, (4S*,5E,10R*)-7-oxo-tri-nor-eudesm-5-en-4β-ol, 7-epi-teucrenone, (+)- (4R,5S,7R)-13-hydroxynootkatone, (E)-labda-12,14-dien-15(16)-olide-17-oic acid) in rats after oral administration of AOF extracts. 27 metabolic metabolites of the five terpenoids were identified by ultra high performance liquid chromatography -Q Exactive hybrid quadrupole-orbitrap high-resolution accurate mass spectrometry (UHPLC-Q-Orbitrap HRMS) based on precise mass and fragment ions.Results:The established pharmacokinetic analysis method showed good linearity over a wide concentration range, and the lower quantitative limit (LLOQ) ranged from 0.97 to 4.25 ng/mL. Other validation parameters were within the acceptable range. In addition, 27 metabolites were identified in plasma, urine and feces samples, and the metabolic pathways of five terpenoids were mainly focused on glucoside conjugation, dehydration, desaturation and glycine conjugation.Conclusion:This is the first study on the pharmacokinetics and metabolism of five terpenoids in AOF, illuminating the disposal process of terpenoids in vivo. It was expected that the results of this study would provide some references for the apprehension of the action mechanism and the further pharmacological study of five terpenoids in AOF.
The Frequency of Random Findings on Abdominal/Pelvis Computed Tomography in Pediatric Trauma Patients
Authors: Baştuğ Betül T. 
Published: December 2020

Aims:
In this study, we aimed to find the percentage of random pathologies and abdominopelvic
region anomalies that are not related to trauma in pediatric patients.

Background:
An abdominal assessment of an injured child usually involves computed tomography
imaging of the abdomen and pelvis (CTAP) to determine the presence and size of injuries. Imaging
may accidentally reveal irrelevant findings.

Objectives:
Although the literature in adults has reviewed the frequency of discovering these random
findings, few studies have been identified in the pediatric population.

Methods:
Data on 142 (38 female, 104 male) patients who underwent CTAP during their trauma
evaluation between January 2019 and January 2020 were obtained from our level 3 pediatric trauma
center records. The records and CTAP images were examined retrospectively for extra traumatic
pathologies and anomalies.

Results:
67 patients (47%) had 81 incidental findings. There were 17 clinically significant random
findings. No potential tumors were found in this population.

Conclusion:
Pediatric trauma CTAP reveals random findings. For further evaluation, incidental
findings should be indicated in the discharge summaries.
Photocatalytic Degradation of Methyl Orange Dye with Synthesized
Chitosan/Fe2O3Nanocomposite and its Isotherm Studies
Authors: Jadon Nimisha , Bhat Gulzar Ahmad , Sharma Manoharmayum Vishwanath , Sharma Harendra Kumar 
Published: December 2020

:
Background: The study focuses on the synthesis of chitosan/Fe2O3 nanocomposite, its
characterization and application in methyl orange dye degradation. Methods: The synthesized chitosan/
Fe2O3 nanocomposite was characterized with Powder X-Ray Diffraction, Fourier
Transfor-­‐
mation
Infrared
Spectroscopy (FTIR), Transmission
Electron
Microscopy
(TEM)
and
UV-­‐Vis
Spectroscopy.
Results:
The
characterization
showed
that
the
Fe2O3nanoparticles were embedded
in the polymer matrix of chitosan. The size of the Fe2O3nanoparticles was less than 10nm and the
crystallite size was 1.22 nm. The
synthesized
chitosan/Fe2O3nanocomposite was tested for methyl
orange degradation using different parameters such as the effect of contact time, effect of dose, effect
of concentration and effect of pH for the degradation of methyl orange dye in aqueous solution. The
Fruendlich, Langmuir and Temkin isotherm studies were also conducted for adsorption of methyl
orange on Chitosan/Fe2O3nanocomposite. Conclusion: The
study
indicated
that
the
synthesized
chitosan/Fe2O3 nanocomposite had the potential of degrading methyl orange dye up to 75.04% under
the set condition in this experiment, which indicates that Chitosan/Fe2O3 nanocomposite is a viable
option that can be used for the degradation of methyl orange dye.
Demonstration of Advanced Data Mining Tools for Optimization of Pellets Employing Modified Extrusion-pelletization Technique
Authors: Rana Hardika , Dholakia Mansi , Gohel Mukesh , Omri Abdelwahab , Thakkar Vaishali , Gandhi Tejal 
Published: December 2020

Background:
The multi particulate drug delivery system is preferred due to its numerous
advantages but the batch to batch consistency and to achieve desired physical properties are the major
challenges in the formulation of such dosage form.

Objective:
The objective of the present study was to explore the concept of quality by design for the
development of galantamine HBr controlled release pellets using a modified palletization technique.

Methods:
Compritol 888 and Ethocel were chosen as hydrophobic release retardants, while Avicel
was chosen as pelletization aid. A compatibility study was conducted between the drug and excipients.
Drug loaded extrudes were prepared by using a mixture of isopropyl alcohol, and dichloromethane.
Before converting the wet extrudes into pellets, pregelatinized starch was sprinkled on them to improve
the physical properties of the pellets. The pellets were characterized for size, shape, and flow.
The critical evaluation parameter was the drug dissolution pattern in distilled water. The dissolution
data were treated with advanced data mining techniques. The in-vivo profile was predicted employing
pharmacokinetic parameters of the drug and in-vitro drug release data of optimized batch pellets.

Results:
The failure mode and effect analysis revealed that the amount of Compritol 888 ATO and
Ethocel were the most critical formulation parameters. The results of FTIR and DSC revealed compatibility
between the drug and the excipients. The spherical pellets exhibited good flow. The drug dissolution
studies of the batches, prepared according to the central composite design, revealed modified
drug release. Multiple regression analysis and analysis of variance were performed to identify statistically
significant factors. Contour plots demonstrated the impact of the amount of Compritol 888 and
ethyl cellulose. The Design-Expert software was used to identify optimized formulation. The predicted
in-vivo plasma concentration-time profile revealed the modified drug release up to 12h.

Conclusions:
Compritol and Ethocel were able to retard the drug release up to 12 hrs in distilled water.
The innovative finding of this study is the use of a dry binder (pregelatinized starch) to improve the
characteristics of pellets. Other dry binders are expected to show a similar effect. The newer processing
technique can be of use in the industry.
Tectonic Keratoplasty in Patients with Non-traumatic, Non-infectious Corneal Perforations
Authors: Cikmazkara Ipek , Selver Ozlem B. , Palamar Melis , Egrilmez Sait , Yagci Ayse 
Published: December 2020

Introduction:The study aims to report clinical results of tectonic keratoplasty for non-traumatic, non-infectious corneal perforations.Materials and Methods:The medical records of 12 patients who underwent tectonic penetrating keratoplasty between October 2014 and August 2018 at Ege University Ophthalmology Department were retrospectively reviewed.Results:The mean age of the patients was 52.92±30.34 (range, 2-82) years. The causes of corneal perforation were dry eye (neurotrophic keratopathy (n=4), limbal stem cell deficiency (n=2), exposure keratopathy (n=2) and graft versus host disease (n=1)) in 9 patients. In the remaining 3 patients, the etiology of perforation was not determined. The mean Visual Acuity (VA) was 2.98±0.39 (range, 1.8-3.1) LogMAR before the surgery. Despite conservative treatment, tectonic penetrating keratoplasty had to be performed in all patients in order to manage the perforation. Mean time in between initial examination and surgery was 10.75±12.04 (1-41) days. In 2 patients, allogenic limbal stem cell transplantation; in one patient, lateral tarsorrhaphy and in one patient symblepharon release with amniotic membrane transplantation were performed additional to tectonic keratoplasty. Mean follow-up time was 57.88±55.47 (4-141) weeks. Grafts were clear in 6 eyes and opaque in 5 eyes. The main causes of graft failure among opaque grafts were ocular surface disease (3), allograft rejection (1) and glaucoma-related endothelial failure (1). Phthisis bulbi was detected in one patient with congenital glaucoma due to vitreous loss at the time of perforation. The mean final VA in patients who had clear grafts was 1.83±1.03 (range, 0.8-3.1) LogMAR.Conclusion:To prevent serious complications in non-traumatic, non-infectious corneal perforations, providing anatomic integrity immediately is a must. If conservative treatment is inadequate or the perforation area is extensive, tectonic penetrating keratoplasty is indicated. Besides, it is important to manage the etiological risk factors in order to obtain successful clinical follow up.
An Exploration of Absenteeism among Nursing Students in the context of a South African University
Authors: Randa Moreoagae Bertha 
Published: December 2020

Background:
Absenteeism among university and college students is a global challenge. Not only does absenteeism result in inadequate learning, but it also disrupts the way in which classes are conducted.

Objective:
The study sought to explore and understand the reasons for absenteeism from the perspectives of the nursing students in the context of a South African University.

Methods:
The study used an explorative qualitative design to conduct four focus group discussions with undergraduate nursing students. Tesch’s method of data analysis was followed.

Results:
One theme and four sub-themes emerged, such as the negative attitudes of lecturers, poor guidance and lack of prompt feedback from lecturers, lack of commitment from lecturers and classes starting late, and inability of the students to cope with the workload.

Conclusion:
The study revealed that the main reasons for the students’ absenteeism from scheduled learning experiences were related to the lecturers’ behaviour and practices. The poor lecturer-student relationship discouraged the students from attending classes.
Review of Research on Hydrostatic Bearings
Authors: Yu Xiaodong , Wang Yu , Wang Junfeng , Zhou Wenkai , Bi Hongwei , Wu Guangpeng , Gao Weicheng 
Published: December 2020

Background:
Hydrostatic bearings possess the advantages of strong bearing capacity, good
stability, small friction coefficient, and long life. The performance of liquid hydrostatic bearings directly
affects the accuracy and efficiency of CNC machining equipment. The performance is conducive to the
development of CNC machine tools towards high speed and heavy load, so it is necessary to sort out and
summarize the existing research results.

Objective:
This study summarizes the current development status of hydrostatic bearings and explains the development
trend of hydrostatic bearings.

Methods:
According to the recently published journal articles and patents, the recent experimental research
on hydrostatic thrust bearings is summarized. This paper summarizes many factors that affect the
performance of hydrostatic bearings, and discusses the effect of various factors on hydrostatic bearings.
Finally, future research on hydrostatic bearings is also presented.

Results:
The study discusses experimental methods, simulation processes, and experimental results.

Conclusion:
Dynamic and static pressure effects can be produced by changing the structure of the oil
cavity of the hydrostatic bearing. This effect can make up for the static pressure loss. By improving the
theoretical formula and mathematical model and proposing a new simulation method, the accuracy of the
hydrostatic bearing simulation can be obtained; the future development trends of the hydrostatic bearing
have been proposed in this paper.
Análise da qualidade de vida de pacientes portadores de dermatoses benignas em um hospital de ensino de Minas Gerais
Authors: Inácio Diego de Souza , Ottoboni Thaíssa Santos de Carvalho , Paula Tatiana Capistrano de , Ribeiro Thaissa Aline , Monteiro Silva Raissa , Brito Izabela Silva , Ribeiro Clarissa Santos de Carvalho 
Published: December 2020

Objetivo: Analisar a qualidade de vida (QV) de pacientes portadores de dermatoses benignas em ambulatório de dermatologia de hospital de ensino do Sul de Minas Gerais. Métodos: Estudo quantitativo, transversal, do tipo pesquisa de campo e de perfil populacional e formas de promoção de saúde, no qual se fez a análise da QV de pacientes portadores de dermatoses benignas (psoríase, vitiligo, melasma, acne, dermatite e rosácea), de fevereiro a julho de 2017. Foram aplicados o Questionário Genérico de Qualidade de Vida - SF36 e o Dermatology Life Quality Index (DLQI-BRA), traduzidos e validados para a língua portuguesa. Resultados: Foram entrevistados 68 pacientes, dos quais 47 eram do sexo feminino (mín. 13; máx. 75 anos). No SF36, os domínios Limitação por Aspectos Emocionais (escore médio, EM, de 57,3) e Vitalidade (EM 58) foram os de pior resultado. No DLQI-BRA, o EM foi de 6,97, sendo Sintomas e Sentimentos (EM 2,69) e Atividades Diárias (EM 1,79) os de maior prejuízo para o doente. Não foram observadas correlações relevantes entre os diferentes domínios de cada questionário. Conclusão: Este estudo identificou piores escores nos Aspectos Emocionais e na Vitalidade do paciente no que diz respeito à QV de forma geral. Em relação à situação dermatológica foi pontuado escore geral de moderado efeito na QV dos pacientes. Os sintomas, sentimentos e as atividades diárias foram os fatores que causam maior prejuízo para o doente.