bluuebunny/crossref_metadata_2025_split huggingface dataset:
Коригування проекту Канівської ГАЕС з урахуванням сучасних вимог енергосистеми України та захисту споруд
Authors: Галат Вадим , Крайник Вадим 
Published: December 2024

Викладено обґрунтування необхідності коригування проекту Канівської ГАЕС та основні напрямки цієї роботи. Розглянуті варіанти вибору основного гідросилового обладнання та захисту об’єкту від силового впливу
Інституційні механізми забезпечення кібербезпеки в Європейському Союзі
Authors: Кардаш Оксана , Гладун Любомир 
Published: December 2024

Проведено дослідження інституційних та організаційно-правових механізмів забезпечення кібербезпеки в Європейському Союзі. Здійснено аналіз співпраці Європейського Союзі з Україною і сфері кібербезпеки. Виокремлено основні загрози кіберпростору ЄС та механізми їх подолання.
A study of institutional and organizational and legal mechanisms for ensuring cyber security in the European Union was conducted. An analysis of the European Union's cooperation with Ukraine and the field of cyber security was carried out. The main threats to the EU cyberspace and the mechanisms for overcoming them are highlighted.
Економічна політика розвитку IT-сфери: досвід Китайської Народної Республіки та українські реалії
Authors: Перкальова Валерія , Королюк Тетяна 
Published: December 2024

У статті розглядається розвиток ІТ-сфери в Україні, яка залишається важливим джерелом економічного зростання та макроекономічної стабільності. Особлива увага приділяється правовому режиму «Дія.City», що стимулює розвиток цифрової економіки та залучення інвестицій. Описано також досвід Китаю в розвитку високих технологій через програму "Made in China 2025" та впровадження національних стандартів кібербезпеки. Україна має потенціал для подальшого зростання в IT-секторі, але потребує додаткових заходів для стимулювання розвитку наукових досліджень, збереження кваліфікованих кадрів та створення інноваційної системи.

The article examines the development of the IT sector in Ukraine, which remains an important source of economic growth and macroeconomic stability. Particular attention is paid to the Diia.City legal regime, which stimulates the development of the digital economy and investment. The article also describes China's experience in developing high technologies through the Made in China 2025 programme and the introduction of national cybersecurity standards. Ukraine has the potential for further growth in the IT sector, but needs additional measures to stimulate the development of scientific research, retain qualified personnel and create an innovation system.
Modeling of Filtration Processes with Extended Sources and Homogenization
Authors: Sandrakov Gennadiy 
Published: December 2024

Methods for modeling dynamic filtration processes with extended sources will be considered. These methods are based on the homogenization of the relevant initial boundary value problems. This approach leads to the description of several filtration modes, the implementation of which depends on the orders of the filtration, transfer, and potentiality coefficients. The problems for describing these modes have constant coefficients and can be solved analytically or numerically. The accuracy of the approximations is also established.
Обчислювальні технології для нелокальних початково-крайових задач гідромеханіки
Authors: Віктор Ванін , Лебідь Олексій , Черній Дмитро 
Published: December 2024

Представлено обчислювальні технології на основі методу дискретних особливостей та їх застосування для нелокальних початково-крайових задач гідромеханіки в областях з різнотипними непроникними рухомими межами
Effect of resistance training and lemon myrtle extract on muscle size of older adults: A pilot randomized controlled trial
Authors: Shuji Sawada  , Azusa Nishino  , Shinichi Honda  , Yuji Tominaga  , Shiori Makio  , Hayao Ozaki  , Shuichi Machida  
Published: December 2024

Background: Recent studies have shown that lemon myrtle leaf (LM) extracts activate muscle satellite cells. This research examined the impact of combining LM extract supplementation with resistance training on muscle hypertrophy in older adults.
Methods: This randomized controlled trial allocated fourteen older adults (65-79 years) to either an LM supplement group (n=7) or a placebo group (n=7). Participants engaged in low-load resistance training twice weekly for 12 weeks while receiving their designated supplements. Muscle thickness at the anterior thigh (AT) was assessed using B-mode ultrasound at baseline, 6 weeks, and 12 weeks to evaluate muscle hypertrophy. Trial registration: UMIN000050432.
Results:.A 12-week intervention yielded significant muscle thickness enhancements in both groups. Nonetheless, the LM group exhibited a substantially greater relative increase (p < 0.05) compared to the placebo group. Furthermore, the low-load resistance training program elicited a significant 7.4% increase in muscle thickness in the LM group at six weeks, whereas the placebo group displayed a negligible 0.1% change.
Conclusions: The present study suggests that intake of LM extract could enhance the muscle hypertrophy effect of resistance training and requires further investigation in the future.
Keywords: sarcopenia, plant extract, muscle hypertrophy, lemon myrtle
Kajian penggunaan madu dan sarang lebah madu oleh masyarakat Pulau Timor sebagai obat tradisional
Authors: Tukan Gerardus Diri , Nadut Anggelinus , Taek Maximus Markus , Lengary Helena Hapa , Tukan Amandha Victoria Dwiputri , Wokal Monika Woli , Lasar Maria Wilhelmina 
Published: December 2024

Madu Timor merupakan salah satu komoditi hasil hutan di pulau Timor yang dikenal oleh masyarakat di luar pulau Timor sebagai salah satu jenis obat herbal. Belum banyak informasi ilmiah mengenai penggunaan madu dan sarang lebah madu oleh masyarakat Timor. Penelitian ini untuk mengetahui penggunaan madu lebah dan sarang lebah madu oleh masyarakat pulau Timor, dalam kaitannya dengan penanganan kesehatahn secara tradisional. Metode penelitian yakni survei di lima kabupaten dalam wilayah Pulau Timor, dengan menggunakan angket sebagai instrumen penggalangan pendapat responden. Hasil penelitian menunjukkan bahwa madu lebah yang dipanen oleh masyarakat untuk dijual dan juga digunakan sebagai obat yaitu dari lebah jenis Trigona sp, Apis cerana dan Apis dorsata. Yang merupakan lebah liar. Jenis penyakit yang diobati menggunakan madu lebah yaitu: sariawan, panas dalam, mag, sakit lambung, batuk dan flu, dan penyakit dalam. Cara penggunaan yakni diminum. Sarang lebah digunakan oleh masyarakat di Timor Tengah Utara sebagai obat batuk, pilek dan penyakit dalam. Cara penggunaannya adalah sarang lebah direbus dan dikonsumsi, dapat dokonsmsi langsung atau dimasak bersama dengan sayur.
Pengembangan Instrumen Asesmen Kompetensi Minimum Numerasi pada Domain Data dan Ketidakpastian untuk Siswa SMP
Authors: Hayati Rohimatul , Nindiasari Hepsi 
Published: December 2024

This study aims to produce valid and practical minimum competency assessment instrument. This study uses the research and development (R&D) of the ADDIE model. The subjects of this study consisted of 32 students in grades VIII SMP Negeri 1 Anyar. The instruments used consisted of expert validation sheets, student response questionnaires, and minimum competency assessment instrument. The data analysis techniques in this study are quantitative analysis and qualitative analysis. Based on the results of research and development of the minimum numeracy competency assessment instrument in the uncertainty and data domain for junior high schools, it was concluded that two questions were very valid, five questions were valid, and one question was invalid. Based on the power of differentiation, invalid questions can be revised or do not need to be used. Meanwhile, the results of the student response questionnaire were obtained by 84%, meaning that it included very practical criteria with 83% for the content aspect, 80% for the construction aspect, and 90% for the language aspect. Thus, this minimum competency assessment instrument can be used in mathematics learning.
Potencial Terapêutico da espécie <i>Minquartia guianensis</i> (Aubl.): uma breve revisão
Authors: Rodrigues Larissa Castro , Rebouças Najara Priscila Batista , Santos Andrei Luiz Castro dos , Garcia Deolinda Lucienne Ferreira 
Published: December 2024

Medicinal plants are elements that make up part of the biodiversity and have been widely used by various peoples and in various ways since the dawn of civilization. The Minquartia guianensis has a high relevance in the commercial sector, because its wood is widely used in the timber market in the Amazon region. However, besides this characteristic, some studies show the medicinal potential of this species. Therefore, this study aimed to search for information about the ethnomedicinal uses used, to describe the botanical aspects, as well as to approach the main methods of extraction and the classes of secondary metabolites with their respective medicinal properties. This integrative review was carried out using databases such as SCIELO, Google Scholar, PUBMED and LILACS. The articles were searched in Portuguese and English, and most were published in the last 20 years. The survey showed the relation of the occurrence of secondary metabolites present in the species, which have antifungal, antibiotic, and anti-inflammatory potential, as well as antimalarial and leishmanicidal activities.
Z dymem pożarów... = Ułłu titinbe...
Authors: Ujejski Kornel , Abrahamowicz Zachariasz 
Published: December 2024

Słowa pieśni odnoszące się do rzezi galicyjskiej Ujejski napisał w 1846 r. do muzyki skomponowanej przez Józefa Nikorowicza. Utwór stał się popularny w czasie Wiosny Ludów, pełniąc zwłaszcza w zaborze austriackim rolę polskiego hymnu. Przekład na język karaimski opublikował po raz pierwszy w 1933 r. Aleksander Mardkowicz na łamach „Karaj Awazy”.
Engraftment of self-renewing endometrial epithelial organoids promotes endometrial regeneration by differentiating into functional glands in rats
Authors: Ma Yana , Qian Jingjing , Xu Xin , Wei Cheng , Wang Minyuan , Zhang Peipei , Chen Sijia , Zhang Lingyan , Zhang Yanling , Wang Yanpeng , Xu Wenzhi , Liu Mengying , Lin Xiaona 
Published: December 2024

IntroductionExtensive trauma frequently disrupts endometrial regeneration by diminishing endometrial stem cells/progenitor cells, affecting female fertility. While bone marrow mesenchymal stem cell (BMSC) transplantation has been suggested as an approach to address endometrial injury, it comes with certain limitations. Recent advancements in endometrial epithelial organoids (EEOs) have displayed encouraging potential for endometrial regeneration. Therefore, this study aims to explore whether EEOs surpass BMSCs in their ability to repair injured endometrium and to examine whether the restoration process involves the integration of EEOs into the endometrial tissue of the recipient.MethodsWe developed rat EEOs (rEEOs) mimicking the features of the rat endometrium. Subsequently, we created a rat model of endometrial injury to compare the effects of rEEOs and rat BMSCs (rBMSCs) on endometrial regeneration and reproductive recovery. Bulk RNA-sequencing analysis was conducted to further investigate the capacity of rEEOs for endometrial regeneration and to identify discrepancies between rEEOs and rBMSCs. Additionally, to track the fate of the transplanted cells in vivo, we transplanted green fluorescent protein (GFP) -labelled rEEOs or red fluorescent protein (RFP) -labelled rBMSCs.ResultsIn a rat model of endometrial injury, we observed that fertility recovery in rats transplanted with rEEOs was more comparable to that of normal rats than in those treated with rBMSC. rEEOs possess a high concentration of endometrial epithelial stem/progenitor cells and secrete vascular endothelial growth factor (VEGF)-A to promote endometrial neovascularization. Significantly, we observed that cells from GFP-labelled rEEOs could integrate and differentiate into functional glands within the injured endometrium of recipient rats.DiscussionEEOs offer a transformative approach to address the challenges of endometrial trauma. Their remarkable regenerative potential holds promise for the restoration of damaged endometrium. As we venture into the future, the concept of utilizing patient-specific EEOs for transplantation emerges as a tantalizing prospect. However, the EEOs in our experiments were mainly cultured in Matrigel, which has barriers to clinical translation as a biomaterial, a new biomaterial to be explored. Secondly, our experiments have been successful only in rat models, and more efforts need to be made before clinical translation.
Influence of acupuncture intensity on analgesic effects in AA rat models
Authors: Wang Yi-Xuan , Liu Yu-Hang , Zhang Zi-Liang , Qiao Xuan , Li Ying-Chen , Ren Liu-Jie , Ding Guang-Hong , Yao Wei , Yu Yi 
Published: December 2024

ObjectiveTo investigate the influence of acupuncture lifting-thrusting frequency and amplitude on the analgesic effects, and its correlation with mast cell degranulation.MethodsAcute adjuvant arthritis (AA) rat models were employed. Robot-arm aided lifting-thrusting acupuncture therapy was conducted with various frequencies (ranging from 0.5 to 4 Hz) and amplitudes (ranging from 0.5 to 2.0 mm). The rats’ pain thresholds were measured multiple times before and after the therapy, and the analgesic effects were evaluated using the pain threshold recovery rate (PTRR), a normalized index. The mast cell degranulation rate (MCdR) at the acupoint was calculated, and a correlation analysis between PTRR and MCdR was performed.ResultsAcupuncture therapy partially restored the pain threshold affected by arthritis. The analgesic effects were influenced by stimulus frequency and amplitude, with best outcomes occurring at an intermediate optimal frequency of 1.0 Hz and amplitude of 1.0–1.5 mm. Similarly, the MCdR peaked at the optimal frequency and amplitude.ConclusionOur animal experiment suggests that optimal analgesic effects can be achieved with stimulation at an optimal intensity. This intensity-effect correlation appears to originate from mast cell activation rates under different mechanical stimulus.
Electronic structure of metal oxide dications with ammonia ligands and their reactivity towards the selective conversion of methane to methanol
Authors: Claveau Emily E. , Miliordos Evangelos 
Published: December 2024

High-level quantum chemical calculations are performed for the (NH3)MO2+ and (NH3)5MO2+ species (M = Ti-Cu), extending our previous work on the bare MO2+ ions. The potential energy curves along the M-O distance are constructed for the ground and multiple excited electronic states of (NH3)MO2+ and are compared to those of MO2+. We see that ammonia stabilizes the oxo states (M4+O2−) over the oxyl (M3+O⋅−) ones. This trend is intensified in the (NH3)5MO2+ species. We then examined the reaction of the latter species with both methane and methanol. We find that the oxyl states activate a C-H bond easily with barriers smaller than 10 kcal/mol across all first-row transition metals, while the barriers for the oxo states start from about 50 kcal/mol for M = Ti and decrease linearly to 10 kcal/mol going toward M = Ni. This is attributed to the increasing spin density on the oxygen atom observed for the oxo states. The most important finding is that the formation of hydrogen bonds between the OH group of methanol and the N-H bonds of the ammonia ligands increases the activation barriers for methanol considerably, making them comparable to and slightly higher than those of methane. This finding suggests a new strategy to slow the oxidation of methanol, leading to the long-desired higher methane-to-methanol selectivity.
Efficacy and safety of acupuncture in the treatment of Meniere’s disease: a systematic review and meta-analysis
Authors: Tang Mingjie , Li Yinghong , Lu Man , Zhang Tianchen , Ge Yanhao , Han Jie , Tang Jiqin , Chen Zhaoming 
Published: December 2024

BackgroundMeniere’s disease (MD) is an idiopathic chronic inner ear disease that seriously impacts patients’ physical and mental health. Medications may be effective for a proportion of patients, and additional effective treatments are still needed. This review aimed to evaluate the efficacy of acupuncture treatment for MD.MethodsEight databases were systematically searched from their inception to June 1, 2024, to identify randomized clinical trials on acupuncture treatment for MD. The Cochrane Risk of Bias 2.0 tool was used to assess the risk of bias in included studies, and meta-analysis was conducted by RevMan 5.4 and Stata 16.0 software.ResultsSix studies were included in this review. The treatment group received acupuncture or acupuncture combined with Western medicine, while the control group was treated with Western medicine. The treatment group was superior to the control group in terms of efficacy rate (RR: 1.20; 95% CI: 1.11–1.29; p &lt; 0.0001). The treatment group reduced dizziness handicap inventory (DHI) (MD: 6.94; 95% CI: 1.58–12.30; p = 0.01), tinnitus handicap inventory (THI) (MD: 6.52; 95% CI: 0.77–12.27; p = 0.03), stuffy ear visual analog scale (VAS) (MD: 0.87; 95% CI: 0.54–1.20; p &lt; 0.0001) and pure tone audiometry score (MD: 6.57; 95% CI: 5.62–7.51; p &lt; 0.0001) to a greater degree than those of the control group. There were some methodological shortcomings in the included studies, including failure to implement blinding, inappropriate outcome measures, and heterogeneity of clinical interventions, such as selected acupoints, acupuncture sessions, and therapist techniques.ConclusionAcupuncture may improve the symptoms of vertigo, tinnitus, ear fullness and hearing loss in patients with MD. However, due to the lack of literature included in this study and methodological weaknesses like randomization, blinding, and clinical heterogeneity, more well-designed long-term follow-up RCTs are needed to evaluate the efficacy and safety of acupuncture.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/(CRD42024549261).
Integrated multi-omics analysis describes immune profiles in ischemic heart failure and identifies PTN as a novel biomarker
Authors: Xiong Ting , Li Quhuan , Wang Yifan , Kong Ying , Li Hailin , Liu Jie , Wu Yueheng , Zhang Fengxia 
Published: December 2024

IntroductionHeart failure is a leading global cause of mortality, with ischemic heart failure (IHF) being a major contributor. IHF is primarily driven by coronary artery disease, and its underlying mechanisms are not fully understood, particularly the role of immune responses and inflammation in cardiac muscle remodeling. This study aims to elucidate the immune landscape of heart failure using multi-omics data to identify biomarkers for preventing cardiac fibrosis and disease progression.MethodsWe utilized multi-omics data to elucidate the intricate immune landscape of heart failure at various regulatory levels. Given the substantial size of our transcriptomic dataset, we used diverse machine learning techniques to identify key mRNAs. For smaller datasets such as our proteomic dataset, we applied multilevel data cleansing and enhancement using principles from network biology. This comprehensive analysis led to the development of a scalable, integrated -omics analysis pipeline.ResultsPleiotrophin (PTN) had shown significant upregulation in multiple datasets and the activation of various molecules associated with dysplastic cardiac remodeling. By synthesizing these data with experimental validations, PTN was identified as a potential biomarker.DiscussionThe present study not only provides a comprehensive perspective on immune dynamics in IHF but also offers valuable insights for the identification of biomarkers, discovery of therapeutic targets, and development of drugs.
Insulin like growth factor 2 mRNA binding protein 2 regulates vascular development in cerebral arteriovenous malformations
Authors: Wang Lin-jian , Wu Yangyang , Xie Sha , Lian Hongkai 
Published: December 2024

BackgroundCerebral arteriovenous malformations (AVMs) are intricate vascular anomalies that disrupt normal cerebral blood flow, potentially leading to severe neurological complications. Although the pathology of AVMs is not fully understood, epigenetic mechanisms have been implicated in their formation.MethodsTranscriptional differences between cerebral AVMs and normal tissues were analyzed using RNA sequencing (RNA-seq), identifying IGF2BP2 as a key differentially expressed gene. Comprehensive bioinformatics analysis, integrating multi-omics data such as RNA-seq and methylated RNA immunoprecipitation sequencing (MeRIP-seq), was employed to identify the downstream target gene of IGF2BP2. The roles of specific genes in vascular development were assessed using endothelial cell cultures and zebrafish models.ResultsOur analysis of RNA-seq data from cerebral AVMs and normal tissues identified IGF2BP2, a key N6-methyladenosine (m6A) reader, as significantly downregulated in cerebral AVMs. Functional studies showed that IGF2BP2 knockdown resulted in abnormal angiogenesis in endothelial cells and disrupted vascular development in zebrafish models. Mechanistically, IGF2BP2 regulates LGALS8 expression by modulating mRNA stability through m6A modification, and LGALS8 deficiency severely impairs angiogenesis in vitro and leads to cerebrovascular dysplasia in vivo.ConclusionOur findings suggest that IGF2BP2, via m6A-dependent regulation of LGALS8, is crucial for vascular development and presents potential targets for therapeutic intervention in cerebral AVMs.
Association between lifelines diet score with odds of nonalcoholic fatty liver disease and some novel anthropometric indices among adults: a case–control study
Authors: Asiaei Sahar , Sharifani Mohammad Sharif , Ghobadian Bijan , Baghdadi Ghazal , Biglari Fereshteh , Rahimlou Mehran 
Published: December 2024

BackgroundNonalcoholic Fatty Liver Disease (NAFLD) is a prevalent condition strongly associated with poor dietary habits and obesity. The Lifelines Diet Score (LLDS), a measure of adherence to a health-promoting diet, may reduce the risk of NAFLD. This study investigates the association between LLDS and NAFLD risk, as well as its relationship with novel anthropometric indices in adults.MethodsThis case–control study included 180 NAFLD patients and 250 controls aged 20–65 years from Valiasr Hospital, Zanjan, Iran. Dietary intake was assessed using a validated 147-item food frequency questionnaire, and LLDS was calculated by scoring food groups according to dietary guidelines. Anthropometric measurements included Body Mass Index (BMI), Waist Circumference (WC), A Body Shape Index (ABSI), Body Roundness Index (BRI), and Visceral Adiposity Index (VAI). Logistic regression models estimated the odds ratios (ORs) for NAFLD across LLDS quartiles.ResultsParticipants in the highest LLDS quartile had significantly reduced odds of NAFLD compared to those in the lowest quartile (OR = 0.49; 95% CI: 0.30–0.65; p &lt; 0.001). Gender-specific analysis revealed that LLDS had a stronger inverse association with NAFLD in females (OR = 0.45; 95% CI: 0.29–0.64) than in males (OR = 0.63; 95% CI: 0.40–0.79). LLDS was inversely associated with VAI (β = −1.14; 95% CI: −2.89, −0.3; p = 0.036), but no significant associations were observed with ABSI or BRI.ConclusionHigher LLDS scores are associated with a lower risk of NAFLD and reduced visceral adiposity, particularly in females. These findings highlight the importance of improving dietary quality as a preventive strategy for NAFLD.