bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammation-Associated Microsatellite Alterations Caused by MSH3 Dysfunction Are Prevalent in Ulcerative Colitis and Increase With Neoplastic Advancement
Authors: Munakata Koji , Koi Minoru , Kitajima Takahito , Tseng-Rogenski Stephanie , Uemura Mamoru , Matsuno Hiroshi , Kawai Kenji , Sekido Yuki , Mizushima Tsunekazu , Toiyama Yuji , Yamada Takuya , Mano Masayuki , Mita Eiji , Kusunoki Masato , Mori Masaki , Carethers John M. 
Published: November 2019

OBJECTIVES:
Inflammation-associated microsatellite alterations (also known as elevated microsatellite alterations at selected tetranucleotide repeats [EMAST]) result from IL-6–induced nuclear-to-cytosolic displacement of the DNA mismatch repair (MMR) protein MSH3, allowing frameshifts of dinucleotide or longer microsatellites within DNA. MSH3 also engages homologous recombination to repair double-strand breaks (DSBs), making MSH3 deficiency contributory to both EMAST and DSBs. EMAST is observed in cancers, but given its genesis by cytokines, it may be present in non-neoplastic inflammatory conditions. We examined ulcerative colitis (UC), a preneoplastic condition from prolonged inflammatory duration.

METHODS:
We assessed 70 UC colons without neoplasia, 5 UC specimens with dysplasia, 14 UC-derived colorectal cancers (CRCs), and 19 early-stage sporadic CRCs for microsatellite instability (MSI) via multiplexed polymerase chain reaction capable of simultaneous detection of MSI-H, MSI-L, and EMAST. We evaluated UC specimens for MSH3 expression via immunohistochemistry.

RESULTS:
UC, UC with dysplasia, and UC-derived CRCs demonstrated dinucleotide or longer microsatellite frameshifts, with UC showing coincident reduction of nuclear MSH3 expression. No UC specimen, with or without neoplasia, demonstrated mononucleotide frameshifts. EMAST frequency was higher in UC-derived CRCs than UC (71.4% vs 31.4%, P = 0.0045) and higher than early-stage sporadic CRCs (66.7% vs 26.3%, P = 0.0426). EMAST frequency was higher with UC duration >8 years compared with ≤8 years (40% vs 16%, P = 0.0459).

DISCUSSION:
Inflammation-associated microsatellite alterations/EMAST are prevalent in UC and signify genomic mutations in the absence of neoplasia. Duration of disease and advancement to neoplasia increases frequency of EMAST. MSH3 dysfunction is a potential contributory pathway toward neoplasia in UC that could be targeted by therapeutic intervention.
Synthesis of 1,2,3 triazole-linked benzimidazole through a copper-catalyzed click reaction
Authors: Bakherad Mohammad , Keivanloo Ali , Amin Amir H. , Farkhondeh Amir 
Published: November 2019

AbstractAn efficient method has been developed for the synthesis of 1,2,3 triazole-linked benzimidazole through a copper-catalyzed click reaction in ethanol at 50°C. A broad range of aromatic azides were successfully reacted with n-propynylated benzimidazole via copper-catalyzed azide-alkyne cycloaddition reactions in the absence of a ligand. This method offers many advantages including short reaction times, low cost, and simple purification procedures.
A Multistage High Performance Amplification Approach for Improving WDM Communication System
Authors: Saini Hardeep Singh , Arora Dinesh , Wason Amit , Sharma Deepak 
Published: November 2019

Abstract
Optical amplifiers are developed to boost up the performance of the communication systems. Amplifiers such as erbium doped fiber amplifier (EDFA), RAMAN and semiconductor optical amplifier (SOA) are used for this purpose. It is mandatory to use optical amplifiers for signal transmission to long distances. In this paper, the hybrid optical amplifier EDFA-RAMAN-EDFA is proposed to enhance the signal quality received at receiver end and to initiate the efficient transmission of 8 × 10 Gbps transmission speed for wavelength division multiplexed (WDM) system. The proposed mechanism is evaluated with respect to various parameters such as quality factor, eye-height, and bit error rate (BER) and eye diagram considering various values of transmission distance ranging from 100 to 200 km. The analysis shows that the proposed mechanism has better quality factor value and minimum BER value than the traditional approach. Wider eye opening for proposed technique represents that the distortions produced in the system are least.
Gebet, Ablass und Heilsaneignung im Mittelalter
Authors: Doublier Étienne 
Published: November 2019

Abstract
This article focuses on the connections between prayer and indulgence established in the 13th and 14th centuries. Since the Early Middle Ages, practices of prayer played a significant role in the ecclesiastical system of penance. They were supposed to provide salvation by redeeming the devotee from sins. With the advent of indulgence, the salvific value of prayer became more closely entangled with the authority of the papacy and the bishops. Generally speaking, papal indulgences were very standardized, and thus only few practices of prayer are mentioned in the respective documents. Episcopal grants of indulgence, on the other hand, were influenced more strongly by their recipients and can thus be more detailed. Two types of prayer indulgences were especially successful: first, indulgences for venerating the Veronica and other holy images, and secondly, indulgences granted to those praying for the King’s salvation.
Das Wiener Euchologien-Projekt: Anlassgebete als Quelle zur Sozial- und Alltagsgeschichte. Drei Fallbeispiele
Authors: Rapp Claudia , Schiffer Elisabeth , Afentoulidou Eirini 
Published: November 2019

Abstract
This contribution showcases the work of the Vienna Euchologia Project which aims to make accessible the ‘small prayers’ or ‘occasional prayers’ that are preserved in the Byzantine euchologia manuscripts from the late 8th to the mid 17th century as sources for daily life and social history. A brief introduction to the project is followed by three thematically focused studies that juxtapose the prescriptive prayers in the euchologia with descriptive evidence from other sources: exorcism and other prayers in hagiographical narratives, prayers with relevance to political history, and prayers relating to women’s purity.
The Fluid Classroom
Authors: Kontopodis Michalis 
Published: November 2019

AbstractThe Western school classroom can no longer remain a secluded and impermeable space in a world that is increasingly hyperconnected through dynamic flows of capital, technologies, populations, media images and ideas. Books brought to the school by diverse students, narratives from far-away countries and YouTube tunes from different cultures can become powerful teaching and learning tools in this frame. Such tools enable multiple metaphors and connections between various life spheres, diverse cultural and socio-economic milieus, and different times and places, as manifested in the thought-provoking ethnographic observation on ‘The book and the author’s reading’ by Elise v. Bernstorff and Carla J. Maier.
Notizen zum Theater Milo Raus
Authors: Westphal Kristin 
Published: November 2019

Abstract

Im Sinne eines Antwortens widmet sich dieser Beitrag den szenischen Beobachtungen und Recherchen wie sie vornehmlich von Birgit Althans und Janna R. Wieland im Theater Milo Raus vorgenommen wurden. Ein erster Fokus liegt zunächst auf der Frage nach dem Affiziert-werden im Theater im Allgemeinen und im Besonderen im Theater Milo Raus. Eine besondere Berücksichtigung erfährt dabei die Frage nach Blickereignissen im Theater unter dem Aspekt des das Theater konstituierende Moment der Fremd-/Scham. Im Weiteren wird auf das paradoxe Verhältnis von Selbst- und Fremdbezug, Realität und Virtualität, Nähe und Ferne, die gleichzeitige Ab- und Anwesenheit von Körperlichkeit im Theater Milo Raus unter erfahrungstheoretischer Perspektive eingegangen, um abschließend der Frage nachzugehen, wie künstlerische Verfahren und wissenschaftliche Verfahren ineinanderzugreifen vermögen.
Abdallah schlägt die Augen nieder
Authors: Bernstorff Elise v. 
Published: November 2019

Abstract
Der folgende Text von Elise v. Bernstorff ist als Transmission des Motivs der Scham aus dem Feld Theater in das Feld Schule entstanden. Er beruht auf einer Situation in einer kurzfristig anberaumten Vertretungsstunde in einer zweiten Klasse der Grundschule einer ländlichen Kleinstadt.
The Politics of Opacity and Translation in Post-Migrant Germany
Authors: Nandi Miriam 
Published: November 2019

Abstract
My commentary focusses on the anecdote described by Elise v. Bernstorff in her research on transcultural education in rural Germany. I am interested in the potential intersections between v. Bernstorff’s findings and my own work on postcolonial literary theory and translation studies. On a methodological level, I am taking my cue from the ethical theory of the Caribbean philosopher Édouard Glissant on the one hand and postcolonial translation studies (Spivak, Tymoczko, Venuti) on the other.
French compounds
Authors: Villoing Florence 
Published: November 2019

Abstract
This article focuses on compounding as a process of word formation within the theoretical framework of lexeme-based morphology. It provides a systematic analysis of the two types of compounding in French: native compounding, the main type, and neoclassical compounding, which is quite marginal. It presents the various rules: native compounds are prototypically constructed of two lexemes and form a third one; they are predominantly endocentric; the governing constituent and the compound head, if any, is on the left and controls the semantic relations between the two constituents, whether coordinated, attributive or subordinating. Neoclassical compounds are prototypically constructed of bound neoclassical elements and form adjectives; they are often exocentric; the governing constituent is on the right. Inflection in native compounds is complex. Several areas of the analysis remain unresolved, particularly regarding the boundaries between morphological/syntactic compounds.
Satellite-framed Latin vs. verb-framed Romance: A syntactic approach
Authors: Acedo-Matellán Víctor , Mateu Jaume 
Published: November 2019

Abstract
In this paper we are interested in the relation between two facts accompanying the diachronic change from Latin to Romance within the domain of the morphological and argument-structural properties of the predicates expressing change. On the one hand, the element encoding the transition itself, which we call the Path, and the verb are realised as two distinct morphemes in Latin, but as one and the same morpheme in the daughter languages: in Talmy's (2000) terms, the former is a satellite-framed language and the latter are verb-framed languages. On the other hand, there is a whole range of argument-structural patterns which are found in Latin but not in Romance: unselected object contructions, complex directed motion constructions, productive locative alternation, etc. We show, within a syntactic view of argument structure and morphology, that both facts are intimately related. Furthermore, we provide data from Old Catalan showing an intermediate stage between the Latin satellite-framed system and the Romance verb-framed system.
Bitonal pitch accent and phonological alignment in Sardinian
Authors: Kim Miran , Repetti Lori 
Published: November 2019

Abstract
This study presents new data on pitch accent alignment in Sardinian, a Romance language spoken in Italy. We propose that what has been described as “stress shift” in encliticization processes is not a change in the word level stress, but variation in the association of the pitch accent. Our claim is that word level stress remains in situ, and the falling tune which our data exhibit can be interpreted as a bitonal pitch accent (HL*) associated with the entire verb + enclitic unit: the starred tone is associated with the rightmost metrically prominent syllable, and the leading tone is associated with the word-level stressed syllable. The research questions we address are twofold: (i) how are the landing sites of the two tonal targets phonetically identified; (ii) how are the phonetic facts reconciled with prosodic structure.
Experimental Investigation on Crack Initiation and Propagation Due to Corrosion of Reinforcement
Authors: Shakib Sheikh , Morshed Abu Zakir 
Published: November 2019

Abstract
In this research, an investigation was carried out through experimentation to explore the mechanism of concrete cover cracking because of expansive pressure induced by corrosion products. The study aimed to monitor structural health by monitoring the crack width and crack propagation in the cover concrete so that the level of corrosion might be discovered. Concrete prisms of 200 by 200 by 300 mm reinforced with 60-grade 12-mm-Ø plain mild steel bar were used to simulate reinforced concrete beams having various cover thicknesses of 20, 37.5, 50, and 75 mm, respectively, to observe the mechanism of crack initiation, propagation, and level of corrosion with respect to the width of surface crack. The level of corrosion was measured in mg/cm2 following Faraday’s law and by gravimetric loss method, and the width of crack was measured by image analysis. For a cover thickness up to 37.5 mm, crack was initiated from the outer face and propagated inward, whereas for a cover thickness of 50 mm and greater, crack was initiated at the steel-concrete interface and propagated outward. A linear relationship was found between crack width and level of corrosion. For cover thicknesses of 20 and 37.5 mm, the critical corrosion amount (CCA) needed to initiate crack was about 22 mg/cm2. However, a sudden increase in CCA was noticed when the cover thickness was 50 mm and greater. For a cover thicknesses of 50 mm and 75 mm, the CCA values were 129 and 211 mg/cm2, respectively.
Compositional Optimization of a Commercially Produced Ferritic Steel Using Microstructural Heterogeneity and Mechanical Properties
Authors: Barat K. , Das G. , Bharathy S. , Ghosh M. 
Published: November 2019

Abstract
Titanium- and niobium-added medium-strength ferritic steels find widespread application in automotive industries. Carbon and nitrogen play an important role in controlling microstructure and mechanical properties of these alloys. In this study, five alloys were selected from commercial heats of the same grade. Carbon and nitrogen contents were different for them. The microstructure of steel consisted of polygonal ferrite with a small quantity of cementite. Two types of precipitates were identified. One group was coherent/semicoherent niobium carbide (NbC) of size &lt;20 nm. Other group was incoherent titanium nitride (TiN)-NbC with size ≥20 nm. The quantity of NbC precipitates primarily contributed in strengthening the mechanism and the rate of strain hardening. The quantity of complex TiN-NbC was controlled by bulk nitrogen content of steel. These incoherent carbides were responsible for the deterioration of the mechanical properties of the alloy.
Pengembangan Modul Virtual Interaktif: Inovasi Sumber Belajar untuk Meningkatkan Hasil Belajar
Authors: Kusrini Dwi , Haryanto Haryanto 
Published: November 2019

This research aims to: (1) generates feasible interactive virtual module as physics learning sources support of grade X senior high school, and (2) generates interactive virtual module in order to improve the achievement of learning outcome. This research method used R & D from model developed by Alessi & Trollip. The development procedures consist of: 1) Planning, 2) Design, 3) Development. The product testing consists of alpha test performed by two media experts and two material expert and beta test conduced through 2 stages that are first beta test (small group trials) of six students and second beta test (large group trials) of thirty two students. The data were analyzed by descriptive qualitative. The results of this research showed: (1) the product resulted in this development research was very feasible based on the evaluation of material experts, media experts and the trial subjects (2) the product proved effective in improving the achievement of learning outcomes, as the evidence of student achieve learning outcomes.
Abstrak
Penelitian ini bertujuan untuk: (1) Menghasilkan modul virtual interaktif yang layak digunakan sebagai penunjang sumber belajar fisika kelas X SMA, dan (2) Menghasilkan modul virtual interaktif untuk meningkatkan capaian hasil belajar. Penelitian ini menggunakan metode R & D dengan mengadaptasi model pengembangan Alessi & Trollip. Prosedur pengembangan terdiri dari: (1) Perencanaan, (2) Desain, dan (3) Pengembangan. Uji coba produk terdiri dari uji alpha yang dilakukan oleh dua ahli media dan dua ahli materi, dan uji beta yang dilakukan melalui 2 tahap yaitu uji beta 1 (uji coba kelompok kecil) pada 6 siswa dan uji beta 2 (uji coba kelompok besar) dilakukan pada 32 siswa. Data yang diperoleh dianalisis secara deskriptif kualitatif. Hasil penelitian menunjukkan: (1) produk yang dihasilkan dinilai sangat layak berdasarkan penilaian para ahli materi, ahli media dan subjek uji coba, (2) Produk terbukti efektif dalam meningkatkan capaian hasil belajar.
Keywords: interactive virtual module; learning resources; learning outcome
STARCH PRODUCTION FROM RED GINGER (Zinggiber officinale Rosc.)
Authors: Widayat Widayat , Striadi H. , Syaiful Syaiful , Kurnia Atik , Driastuti Faradilla 
Published: November 2019

Red Ginger is a natural ingredient including to spice that contain starch 40-60 % weight. Application of red ginger usually it is taken its extract or to taste of traditional food. The purpose of this research is to know the influence of settling time, the red ginger and solvent ratio, and the temperature of the solvent in the production process of red ginger starch. We hope to get the best condition to get the highest starch yield. The process of making red ginger starch begins with peeled, then washed, shredded, filtered and precipitated. Starch ginger dried by the sun's heat. The best result was obtained at 1 hour sedimentation time with red ginger starch yield 13,3%, red ginger and water ratio 3: 5 (g / g) with yield of red ginger 15,69% and temperature of solvent at 25 ᵒC with yield of red ginger starch 11.17%.
TRACER STUDY RELEVANSI KOMPETENSI LULUSAN PROGRAM STUDI PENDIDIKAN KEPELATIHAN OLAHRAGA DENGAN KEBUTUHAN LAPANGAN KERJA
Authors: Soedjatmiko Soedjatmiko 
Published: November 2019

Jenis penelitian ini adalah penelitian kuantitatif dengan desain riset deskriptif kuantitatif. Desain deskriptif kuantitatif bertujuan untuk menjelaskan sesuatu, seperti : menjelaskan suatu kelompok yang relevan. Populasi penelitian ini adalah seluruh mahasiswa lulusan Prodi PKLO yang lulus sepuluh tahun terakhir yaitu antara 2007 sampai 2017 yang telah bekerja. Sedangkan sampel yang diambil adalah masing-masing 10 alumni pada tiap tahun kelulusan. Metode pengumpulan data menggunakan kuesioner yang disampaikan melalui email attachment maupun dikirim melalui pos dalam bentuk hard copy. Dari analisis data diperoleh data 1) usia responden yang mengisi kuesioner sebanyak 69,8 persen berusia dibawah 30 tahun, sisanya 30,2 % berusia 30 tahun ke atas. Alamat responden sebanyak 52 % tinggal di karesidenan Semarang dan Karesidenan pekalongan. Sisanya sebesar 48 % tinggal di karesidenan pati, Banyumas, Tegal dan luar Jawa Tengah. Lama masa studi responden didapat hasil sebesar 53,8 % lulus 4 tahun atau kurang. Sisanya 46,2 % lulus setelah 4 tahun dan hanya 4,8 % yang lulus lebih dari 5 tahun. Untuk jenis pekerjaan mayoritas responden atau sebesar 71,4 % menjadi guru/dosen, 12,7 % bekerja di bidang lain serta 15,9 % belum bekerja. Selanjutnya untuk masa tunggu lulusan didapat data sebanyak 49,2 % memperoleh pekerjaan dalam kurun waktu 0 sampai 11 bulan, yang memperoleh pekerjaan antara 11 sampai 23 bulan sebanyak 36,5 % dan yang memperoleh pekerjaan dua tahun lebih sebesar 14,3 %. Simpulan sebagai berikut : 1) Hasil penelitian tracer study ini didapat data tentang alumni yang terdiri dari jenis pekerjaan, lama studi, lama masa tunggu pekerjaan, relevansi kurikulum dan pekerjaan serta maasukan dari Alumni. 2). Mayoritas responden mengusulkan ada penelitian tentang tracer study yang diadakan secara berkala agar mereka dapat menyumbangkan tenaga dan pikirannya. 3) Mayoritas responden mengusulkan adanya rekonstruksi kurikulum agar Program studi selalu dapat mengembangkan diri dan dapat menjawab tantangan perkembangan jaman. 4) Program studi Pendidikan Kepelatihan Olahraga sangat membutuhkan Tracer Study untuk mendapatkan umpan balik dari alumninya dan dari stake holder lulusan
Rancang Bangun Alat Monitoring Pergerakan Objek pada Ruangan Menggunakan Modul RCWL 0516
Authors: Aini Qurotul , Rahardja Untung , Madiistriyatno Harries , Fuad Azharul 
Published: November 2019

Nowdays, along with the development of electronics and computers, the crime rate increases rapidly. today almost all systems and security tools are using electronic devices such as computers and microcontrollers. Every electronic device always has weakness, such as camera needs the light to capture images, Passive InfraRed (PIR) sensor only has ability for human body temperature detection, Short Message Service (SMS) which its services depend on prepay credit and cellular operator signal range. Based on the problem, a radio-based doppler radar detection tool was developed using RCWL 0516 module. In this research will be discussed the use of RCWL 0516 sensor as main module to detect the movement of the object by measuring the microwave wave value that displayed on the user gadget by using Blynk application. The digital communication is used and implemented on Arduino Uno microcontroller. The data is sent and will be displayed on the gadget through Blynk application in the form of graph in real time and connect to the internet using ESP8266 as a connection receiver. The results obtained that the RCWL 0516 module has a better accuracy level in detecting movement than other motion detection sensors such as PIR sensors and ultrasonic sensors.