bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of aortic insufficiency in patients with left ventricular assist device ̶ a retrospective analysis
Authors: Bittner Hartmuth B. 
Published: October 2019

Background
Aortic insufficiency is increasingly recognized as a complication of left ventricular assist device (LVAD) support and may lead to clinical decompensation requiring correction. This article describes experiences in managing patients presenting with concomitant aortic insufficiency and with de novo aortic insufficiency following left ventricular assist device implantations.
Methods
All patients undergoing LVAD implantation between 2012 and 2014 were included in this retrospective analysis if aortic valve insufficiency was present on implantation or newly developed (de novo) after implantation. Moderate to severe aortic valve insufficiency was corrected at implantation.
Results
The data of 39 patients were included. At the time of LVAD implantation, moderate to severe aortic valve insufficiency was present in 3 patients and was corrected by bioprosthetic valve replacement (2 patients) and by bioprosthetic valve replacement associated with ascending aorta with hemi arch replacement with a graft due to ascending aortic aneurysm (one patient). Four patients developed moderate to severe aortic insufficiency after LVAD surgery. Treatment with conservative medical management was successful in 3 patients. One patient underwent transcatheter aortic valve occlusion using an Amplatzer closure device after failure of medical management.
Conclusions
Concomitant aortic valve replacement with LVAD implantation is a safe and viable option in managing aortic valve insufficiency. De novo aortic insufficiency may lead to recurrent heart failure and presents a clinical treatment challenge following successful LVAD support; the most appropriate and effective treatment option awaits definition.
Exploring the “Weekend Effect” on the Care of Patients with Left Ventricular Assist Devices
Authors: Ogunbayo Gbolahan , Ha Le Dung , Misumida Naoki , Elbadawi Ayman , Ahmad Qamar , Okwechime Remi , Akanya Deborah , Kolodziej Andrew , Elayi Claude S. , Guglin Maya 
Published: October 2019

Background
Many studies have described differences in in-hospital outcomes and length of stay between patients treated for major cardiac conditions on weekdays versus weekends.1 Our study aimed to explore the “weekend effect” on in-hospital care among patients with left ventricular assist devices.
Methods
Using data from the National Inpatient Sample (NIS) database, with a weighted estimate of more than 35 million admissions per year.2 We identified patients 18 years or older with an ICD code signifying presence of a LVAD. Characteristics, comorbidities and clinical outcomes were compared between patients admitted on a weekend versus patients admitted on a weekday. The outcomes of interest were in-hospital all-cause mortality and length of hospital stay (LOS).

Results
Patients admitted on weekend days were younger, otherwise both groups were similar with respect to comorbidities. Patients admitted on weekend days were more likely to have cardiogenic shock, septic shock and respiratory failure. They were also more likely to require mechanical ventilation and undergo cardiac transplantation. Patients admitted on a weekend day however had a shorter hospital median hospital stay. This remained significant after multivariate analysis (OR .81 95% CI .72-.91, p<0.01).
Our data analysis from this large database demonstrates no effect of weekend admission on all-cause mortality among patients with LVADs, although patients admitted on weekend days were more likely to have shorter hospital stay.
Effects of Beta Blockers and ACE Inhibitors after Left Ventricular Assist Device Implantation
Authors: Vaidya Gaurang , Birks Emma , Pillarella Jessica , Salgado Benjamin , Vijayakrishnan Rajakrishnan , Lenneman Andrew , Slaughter Mark , Abramov Dmitry 
Published: October 2019

Background
While Beta blockers(BB) and Angiotensin system blockers(ACEinh/ARB) are important components in advanced heart failure therapy, their use after left ventricular assist device (LVAD) implantation remains controversial. Concern has been raised about possible adverse effects of BB on right ventricular(RV) function while tolerance and efficacy/outcome data for ACEinh are lacking. This study aimed to characterize the use of medical therapy post-LVAD implantation and to evaluate its safety and efficacy.
Methods
Demographic, clinical and echocardiographic variables of patients implanted with a continuous-flow LVAD between 2012 and 2015 at a single center were retrospectively reviewed. Mortality and heart failure(CHF) hospitalizations were followed from 6-18 months’ post-implant.
Results
Of a total of 98 patients, the mean age was 57 years, 81% were men and 61% had ischemic disease. While the use of diuretics decreased considerably post LVAD, over 50% continued to require diuretics. At 6th month post-implantation, 73% of patients were on BB, and these patients had significantly lower proBNP at 6 and 12 months follow up. Despite significant prevalence of RV dysfunction in the cohort (>75% at 6 months), there was no significant difference in CHF hospitalizations based on BB use (14% vs 15%) and instead a trend towards less deaths in those on BB (6% vs 15%). ACEinh/ARB use was likewise common at 6 month (61%) and these patients had lower proBNP at 6 and 12 months, lower right atrial(RA) pressures (9 vs 12 mmHg, p=0.03), and a significantly lower mortality—a finding which remained on multivariate analysis.
Conclusion
The use of ACEinh/ARB appeared to be associated with subsequent improved survival, lower proBNP and RA pressures. The use of BB post-LVAD appears safe and was associated with a lower proBNP, even in a patient population with a significant prevalence of RV dysfunction.
‘Isolated’ germline mosaicism in the phenotypically normal father of a girl with X-linked hypophosphatemic rickets
Authors: Lin Yunting , Cai Yanna , Xu Jianan , Zeng Chunhua , Sheng Huiying , Yu Yang , Li Xiuzhen , Liu Li 
Published: October 2019

Objective
X-linked hypophosphatemic rickets (XLHR) is the most common form of inherited rickets caused by pathogenic variants of PHEX gene with an X-linked dominant inheritance pattern. Precise molecular diagnosis of pathogenic variant will benefit the genetic counseling and prenatal diagnosis for the family with XLHR. Here, we presented an ‘isolated’ germline mosaicism in the phenotypically normal father of a girl with XLHR.

Methods and results
For the initial molecular screen of PHEX gene, DNA samples of the proband and her parents were extracted from their peripheral blood samples respectively. Sanger sequencing found a ‘de novo’ novel heterozygous variant, c.1666C>T(p.Q556X), at the PHEX gene in the proband, but not in her phenotypically healthy parents. Due to an occasional abnormality of his serum phosphate previously, further examinations for the father were taken to exclude the possibility of paternal mosaicism. Eight samples from different tissues were analyzed for PHEX gene by Sanger sequencing. Surprisingly, one ‘isolated’ germline mosaicism was detected only in his sperm with an estimated frequency of 26.67%. The mosaic allele was identical to the c.1666C>T(p.Q556X) variant in the proband.

Conclusions
This is the first case of ‘isolated’ germline mosaicism with pathogenic PHEX variant. Our study provides accurate diagnosis and valuable counseling for this family. This report also alerts clinicians and geneticists to exclude the possibility of the isolated germline mosaicism and prevent intrafamilial recurrences of inherited diseases.
The Role of Fashion Bloggers in Fashion Marketing Communication
Authors: Mickevičiūtė Akvilė , Siudikienė Daiva 
Published: October 2019

Because of digitization and internet development that took place in the 21st century, fashion industry has been consistently encountering various challenges. While the popularity of social media continues to grow, a new player in fashion industry, along with the medium they control, has emerged – the fashion blogger and the fashion blog. After gaining millions of followers on social media, bloggers acquired a certain power position – they can influence the opinion of their audience. With the popularity of social media, fashion bloggers, who gain a certain position of power through the acquisition of large numbers of followers across social networks, can shape their followers’ opinions, present a variety of fashion product reviews, and participate in the consumer decision-making processes. For fashion companies, collaborations with bloggers are becoming more relevant and an increasing part of a fashion brand marketing strategy. This article introduces theoretical and empirical research that was carried out to analyze and explore the role of fashion bloggers in modern fashion marketing communication. Fashion companies seek to exploit this advantage for commercial purposes and include blogs as advertising channels into their marketing strategy. This article aims to analyze the role of blogs in the modern fashion industry. In order to reach that, the following objectives were set: to research the attributes of the fashion industry and fashion marketing in the 21st century; to analyze the definition, features, types, and significance of fashion blogs with reference to the current fashion industry; to examine the aspects of connection forming between fashion blogger and its audience; to explore the features of Lithuania’s fashion bloggers’ activities and the strategies they use to develop their ties with significant target audiences of the fashion sector. In order to reach the aim of research, two empirical research methods were combined: semi-structured interviews with fashion bloggers and a questionnaire for the followers of fashion blogs. During the study it was established that the role of Lithuania’s fashion blogs is best seen in fashion marketing – blogs are the mediators between fashion companies and consumers. They form a personal bond with consumers and organically disseminate fashion trends to a wide audience.
Захар Прилепин – литературный портрет
Authors: Borkowska Aldona 
Published: October 2019

Со времени дебюта в 2004 году имя Захара Прилепина постоянно присутствует в литературном пространстве России. Филолог, журналист, писатель, политический деятель и военный, он – автор целого ряда романов, каждый из которых стал символом своего времени и поколения. Писатель получил основные литературные премии России и завоевал признание как маститых критиков, так и обычных читателей. Цель настоящего исследования – сформировать литературный портрет Захара Прилепина, прояснение его популярности среди русских читателей.
Ситуация порога в исторической притче Э. Радзинского „Лунин, или Смерть Жака”
Authors: Журчева Ольга 
Published: October 2019

Статья посвящена разбору исторической притчи Э. Радзинского Лунин, или Смерть Жака, записанная в присутствии хозяина. Исходя из жанровой парадигмы притчи, Э. Радзинский выстраивает конфликт пьесы с помощью пороговой ситуации ожидания главным героем казни. Лунин, ожидая смерти, вспоминает всю свою жизнь, поэтому все действие пьесы сосредоточено в реальном и в ментальном времени и пространстве. В реальности Лунин один в камере, в воображении его окружают множество людей, которых он встречал на своем пути. Этот сюжетный парадокс создает иллюзию визуализации воспоминаний героя и публичности его смерти.
Феномен Гузели Яхиной (к восприятию романа „Зулейха открывает глаза”)
Authors: Ситникова Вера 
Published: October 2019

В статье анализируются значимые аспекты романа Г. Яхиной Зулейха открывает глаза и его восприятие критикой. В частности, рассматриваются связи художественного мира романа с традициями русской литературы в изображении «естественного человека», особенности звучания вечных тем любви, материнства, веры, становления личности, своеобразие раскрытия темы репрессий 1930-х годов. Осмыслены основные тенденции суждений критиков и рецензентов, сделана попытка объяснить причины успеха романа у читателей.
Mara Glozman y Daniela Lauria Voces y Ecos. Una antología de los debates sobre la lengua nacional (Argentina, 1900-2000), Buenos Aires, Ediciones Biblioteca Nacional, Cabiria, 2012. Reseña
Authors: Chapa Barrios José Fernando 
Published: October 2019

Se reseña el texto Voces y ecos. Una antologia de los debates sobre la lengua nacional (Argentina, 1900-2000)
Flow Induced Vibration and Movements Modelling on Multiphase Pipeline on Russian Far North Green Field
Authors: Goridko Kirill , Khabibullin Rinat , Verbitsky Vladimir 
Published: October 2019

Abstract
Novoportovskoe field is located on the Yamal peninsula, Russian Far North. Production started in 2016. The production gathering system utilizes an 8 km, 800 mm ID multiphase pipeline located on surface. Due to permafrost the pipe lays 1 to 5 meters above surface on a concrete support. In order to reduce the risk of temperature influence, 35 U-shaped expansion units are used. An oil field experience high GOR grows with average fluid velocity in pipeline about 15 m/sec and GOR above 500 m3/m3. The slug flow condition and high fluid velocities leads to severe flow impact on the pipeline.
A model based on dynamic multiphase flow simulator and simplified mechanical influence was built to investigate pipeline operation conditions. Vibration measurements gathered on site were used to calibrate the model. Recommendations for further oil field infrastructure development were proposed.
Identification of novel alternative splicing isoform biomarkers and their association with overall survival in colorectal cancer
Authors: Jia Hongtao , Wang Aili , Lian Haifeng , Shen Yuanyuan , Wang Qian , Zhou Zhenru , Zhang Ranran , Li Kun , Liu Chengxia 
Published: October 2019

Abstract
Alternative splicing is an important mechanism of regulating eukaryotic gene expression. Understanding the most common alternative splicing events in colorectal cancer (CRC) will help developing diagnostic, prognostic or therapeutic tools in CRC. Publicly available RNA-seq data of 31 pairs of CRC and normal tissues and 18 pairs of metastatic and normal tissues were used to identify alternative splicing events using PSI and DEXSeq methods. The highly significant splicing events were used to search a database of The Cancer Genome Atlas (TCGA). We identified alternative splicing events in 10 genes marking the signature of CRC (more inclusion of CLK1-E4, COL6A3-E6, CD44v8-10, alternative first exon regulation of ARHGEF9, CHEK1, HKDC1 and HNF4A) or metastasis (decrease of SERPINA1-E1a, CALD-E5b, E6 and FBLN2-E9). Except for CHEK1, all other 9 splicing events were confirmed by TCGA data with 382 CRC tumors and 52 normal controls. Two splicing events (COL6A3 and HKDC1) were found to be significantly associated with patient overall survival. The alternative splicing signatures of the 10 genes are highly consistent with previous reports and/or relevant to cancer biology. The significant association of higher expression of the COL6A3 E5-E6 junction and HKDC1 E1-E2 with better overall survival was firstly reported. This study might be of significant value in the future biomarker, prognosis marker and therapeutics development of CRC.
Shear Wave Elasticity by Tracing Total Nodule Showed High Reproducibility and Concordance with Fibrosis in Thyroid Cancer
Authors: Yoo Myung Hi , Kim Hye Jeong , Choi In Ho , Park Suyeon , Kim Sang Jin , Park Hyeong Kyu , Byun Dong Won , Suh Kyoil 
Published: October 2019

Abstract
Background Although shear wave elastography (SWE) is reported to be useful in detecting malignant thyroid nodules, it showed a wide range of cut-off values of elasticity index (EI) in detecting malignant nodules. The cause of discrepancy has not been clarified yet. Fibrosis of the tumors is known to increase the EI in SWE, and matching of SWE and surgical histopathology has not been fully illustrated in thyroid cancer. We aimed to evaluate the reproducibility of the new total nodular region of interest (ROI) method excluding the subjective features of focal circular ROI placement and to determine the lesion that causes the elevation of EI on SWE and on histopathology.
Methods A total of 29 thyroid cancers from 28 patients were included. We evaluated the reproducibility of EI in the new total nodular ROI using Q-Box Trace program and compared the EI in focal nodular ROI using a 3-mm circular area. We analyzed the correlation between fibrosis and EI.
Result The coefficient of variation (CV) of the intrarater assay was significantly lower in total nodular ROI than in focal nodular ROI within the image in rater 1 (1.7% vs. 13.4%, p<0.001) and in rater 2 (1.4% vs. 16.9%, p<0.001) and in different images in rater 1 (7.6% vs. 12.3%, p=0.040) and in rater 2 (7.5% vs. 19.8%, p=0.004). Moreover, CV of the interrater assay showed similar results (14.9% vs. 19%, p=0.030). Interrater intraclass correlation coefficient showed better agreement in total nodular ROI than in focal nodular ROI (0.863 vs. 0.783). The degree of fibrosis on histopathology showed significant correlations with EI (EMean, p<0.001; EMax, p=0.027), and the location of fibrosis was concordant with the high EI area on SWE.
Conclusion Our study revealed that the new total nodular ROI method showed higher reproducibility and better agreement in intra- and interrater assay than the focal nodular ROI method, suggesting a valuable and standardized method in clinical practice. Moreover, our results showed that fibrosis in the histopathology increased EI on SWE and might lead to the discrepancy of the cut-off values in detecting thyroid cancer.
Cytokeratin 7-Negative and GATA Binding Protein 3-Negative Breast Cancers: Clinicopathological Features and Prognostic Significance
Authors: Lu Shaolei , Yakirevich Evgeny , Wang Li Juan , Resnick Murray B , Wang Yihong 
Published: October 2019

Abstract
Background: Cytokeratin 7 (CK7) and GATA binding protein 3 (GATA3) are considered as immunohistochemical hallmarks of breast cancers; however, there are breast tumors lacking these markers. Clinicopathological characterization of CK7 negative breast cancer has not been addressed previously and similar studies on GATA3 negative tumors are limited.
Methods: This study included 196 consecutive cases of Nottingham Grade 3 breast cancers with 159 cases of Grade 1 and Grade 2 tumors for comparison. CK7 and GATA3 expression was correlated with patient’s age, histological type, pathological grade and stage, hormone receptor status, molecular subtype and overall survival.
Results: CK7 negativity was seen in 13% of Grade 3, 9% of Grade 2, and 2% of Grade 1 cases (P=0.0457). Similarly, 28% of Grade 3, 5% of Grade 2 and 2 % of Grade 1 cases were GATA3 negative (P<0.0001). CK7 negative tumors did not show association with other clinicopathological parameters. GATA3 negative tumors were enriched in the basal-like molecular subgroup and were associated with negative estrogen receptor (ER) and negative progesterone receptor (PR) statuses. Both CK7 and GATA3 expression showed no association with overall survival in patients with Grade 3 tumor.
Conclusions: This is the first study to characterize CK7 negative breast tumors in the context of clinicopathology. Profiling the CK7 negative and GATA3 negative breast cancers helps to understand the biology of these specific tumor subgroups and may aid in their diagnosis.
Hygiene protocols for the treatment of denture-related stomatitis: local and systemic parameters analysis - a randomized, double-blind trial protocol.
Authors: Author) Adriana Barbosa Ribeiro(Former Corresponding , de Araújo Camila Borba , Silva Luiz Eduardo , Fazan-Junior Rubens , Salgado Helio Cesar , Ribeiro Aline Barbosa , Fortes Caroline Vieira , Bueno Frank Lucarini , Oliveira Viviane de Cássia , Paranhos Helena de Feitas Oliveira , Watanabe Evandro , Silva-Lovato Cláudia Helena 
Published: October 2019

Abstract
Background. The Denture-related stomatitis (DS) is a chronic multifactorial inflammation, strongly related to the presence of the biofilm that is the complex structure formed by microorganism held together by a mucus-like a matrix of carbohydrate that adheres to different surfaces, including denture surface. DS has recently been correlated with deleterious cardiovascular alterations. The potential effect of hygiene protocols in the control of DS and Randomized clinical trials that address this oral condition with cardiovascular complications are necessary for clinical decision-making.
Material/design. A clinical trial, randomized, double-blind, of parallel groups, will be conducted in Brazil and the sample will be composed of 100 patients without teeth in both arches, users of at least maxillary complete dentures, diagnosed with DS that will be allocated in groups (n=25), according to the different hygiene protocols: (1) brushing of the palate and immersion of the prosthesis in 0.25% sodium hypochlorite solution (positive control); (2) brushing of the palate and immersion of the prosthesis in 0.15% Triclosan solution; (3) brushing of the palate and immersion of the prostheses in lactose monohydrate; (4) brushing the palate with citric acid and immersing the prosthesis in lactose monohydrate. The response variables will be: heart rate variability and alteration of blood pressure (systemic level), remission of Denture-related Stomatitis, removal of biofilm, reduction of microbial load (CFU), mouth and prosthesis odor level, expression of MUC1, proinflammatory cytokines, C-reactive protein level - CRP, viscosity, pH and salivary flow (locally); qualitative analysis patient-centred will also be held. Measurements will be performed in the Baseline and ten days after the interventions. The results obtained will be submitted to the pertinent statistical analysis with a level of significance of 0.05.
Discussion. This study will provide a guideline of clinical practice regarding the use of hygiene protocols in the treatment of oral diseases (DS) mediated by biofilm. Also, it may provide evidence of correlation of oral manifestation with cardiac risk.
International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) - the propagation of knowledge in ultrasound for the improvement of OB/GYN care worldwide: experience of basic ultrasound training in Oman
Authors: Vrachnis Nikolaos , Papageorghiou Aris T. , Bilardo Caterina M. , Abuhamad Alfred , Tabor Ann , Cohen-Overbeek Titia E. , Xilakis Eleni , Mates Flora , Johnson Sarah , Hyett Jon 
Published: October 2019

Abstract
Background: The aim of this study is to evaluate effectiveness of a new ISUOG (International Society of Ultrasound in Obstetrics and Gynecology) Outreach Teaching and Training Program delivered in Muscat, Oman.
Methods: Quantitative assessments to evaluate knowledge and practical skills were administered before and after an ultrasound course for sonologists attending the ISUOG Outreach Course, which took place in November, 2017, in Oman. Trainees were selected from each region of the country following a national vetting process conducted by the Oman Ministry of Health. Twenty-eight of the participants were included in the analysis. Pre- and post-training practical and theoretical scores were evaluated and compared.
Results: Participants achieved statistically significant improvements, on average by 47% (p<0.001), in both theoretical knowledge and practical skills. Specifically, the mean score in the theoretical knowledge test significantly increased from 55.6% (± 14.0%) to 81.6% (± 8.2%), while in the practical test, the mean score increased from 44.6% (± 19.5%) to 65.7% (± 23.0%) (p<0.001). Performance was improved post-course among 27/28 participants (96.4%) in the theoretical test (range: 14% to 200%) and among 24/28 (85.7%) trainees in the practical skills test (range: 5% to 217%).
Conclusion: Application of the ISUOG Basic Training Curriculum and Outreach Teaching and Training Course improved the theoretical knowledge and practical skills of local health personnel. Long-term re-evaluation is, however, considered imperative to ascertain and ensure knowledge retention.