bluuebunny/crossref_metadata_2025_split huggingface dataset:
Main problems of the research on the Palaeolithic of Halych-Dnister region (Ukraine)
Authors: Bogucki Andriy , Tomeniuk Olena , Sytnyk Oleksandr , Koropetskyi Ruslan 
Published: September 2020

Abstract
The article presents the results of the Palaeolithic loess sites studies in the Halych-Dnister region. It is an area in the Dnister River basin (Ukraine) with a large number of Middle and Upper Palaeolithic sites (Yezupil I, Halych I, Halych II, Mariampil I, Mariampil V, Mezhyhirtsi, Kolodiiv, Hannusivka, etc.), which have been discovered and studied including multilayered ones. It is open-air Palaeolithic sites related to widespread distribution in the region Pleistocene loess-palaeosol sequence reaching up to 30 m thickness, sometimes even more. Palaeolithic sites have been investigated using various field and laboratory archaeological and natural science research methods. Defined cultural horizons of the sites are stratified and dated by luminescent and radiocarbon methods, and their cultural identity is characterized. In the Halych-Dnister region, the most developed are the Middle Palaeolithic (Levallois, Micoquian) cultural horizons as well as the Gravettian techno-complexes of the Upper Palaeolithic. During our research, some scientific problems have been identified in studying the Palaeolithic sites of Halych-Dnister region. They are described in the article. As our practice has shown, issues such as the interpretation of the taphonomy and chronology of archaeological artefacts, the determination of the cultural identity of the archaeological site or particular cultural horizons, the underestimation of the redeposition of cultural layers, the role of palaeorelief and the deluvial–solifluction processes in it, the incompleteness of geological sections of archaeological sites are often debatable among researchers. In the light of the increasing anthropogenic impact on the environment, the issue of rationale, certification and protection of Palaeolithic sites is becoming more urgent. The main purpose of the article is to analyse these issues and find ways to resolve them.
Peritoneal fluid biomarkers in patients with endometriosis: a cross-sectional study
Authors: Nirgianakis Konstantinos , McKinnon Brett , Ma Lijuan , Imboden Sara , Bersinger Nick , Mueller Michael D. 
Published: September 2020

Abstract

Objectives
Elevated concentrations of numerous molecules have been reported in the peritoneal cavity of women with endometriosis. Until now, no factor proved sufficiently specific to endometriosis. We aimed to investigate several biomarkers in endometriosis and report their association with the menstrual cycle in a large sample size study.

Methods
Patients of reproductive age undergoing laparoscopic procedures for benign pathology in the Department of Obstetrics and Gynaecology, University of Bern between 2007 and 2018 were included. Exclusion criteria were the use of hormonal treatment in the three months prior to surgery, patients suffering from other inflammatory diseases, pregnancy, malignancy and surgery performed in an emergency. The concentrations of 13 different biomarkers in the peritoneal fluid (PF) were compared between patients with and without endometriosis both in the proliferative and the secretory cycle phase.

Results
Out of 1,256 patients in the database, 521 met the inclusion and exclusion criteria. Glycodelin (PP14) and Midkine concentrations were significantly higher in patients with endometriosis compared to controls irrespective of the cycle phase in which the PF was collected. Interleukin-8 (IL-8), regulated on activation normal T cell expressed and secreted (RANTES) and osteoprotegerin (OPG) concentrations were higher in patients with endometriosis only in the proliferative cycle phase. Monocyte chemoattractant protein 1, CCL2 (MCP-1) and Defensin concentrations were higher in patients with endometriosis only in the secretory cycle phase.

Conclusions
Certain pathophysiological processes may take place only in the one cycle phase leading to a temporary increase of specific PF biomarkers. Correlation with clinical outcomes is mandatory to establish their potential as prognostic or therapeutic tools in endometriosis.
Effect of hydrothermal coupling on energy evolution, damage, and microscopic characteristics of sandstone
Authors: Rongrong Zhang , Qinyong Ma , Qi Ping , Dongdong Ma 
Published: September 2020

AbstractHeat–cool (H–C) cycle is a serious natural weathering mechanism for rock engineering in temperate desert climate; meanwhile, engineering rocks usually involve responses to impact loads arising from blasting operation, mechanized construction, and seismic oscillation. Considering the universality and destructiveness of rock failure caused by H–C cycle weathering coupled with dynamic loading, split Hopkinson pressure bar tests were conducted for sandstone with various H–C cycles. Additionally, hydrothermal coupled damage (D) was defined based on variation of total import strain energy. Energy evolution, damage, and microscopic characteristics of sandstone after diffierent H–C cycles were studied. Finally, the microcosmic structure changes of sandstone after various H–C cycles are compared by means of scanning electron microscopy (SEM) and energy dispersive spectrometer (EDS) technology. Results show that decreasing rate of total import strain energy in high temperature group is significantly larger compared with that in low temperature group and moderate temperature groups. Repeated H–C cycles produce the thermal stress at the mineral boundary constantly and fracture along the boundary of the mineral particle according to the SEM and EDS results.
Democratizing the Doctrine of Unconstitutional Constitutional Amendments: The Puzzle of Amending the Judiciary Branch
Authors: Torres-Artunduaga Catalina , García-Jaramillo Santiago 
Published: September 2020

Abstract
The increasing interest of legal academia on the doctrine of Unconstitutional Constitutional Amendments and its growing enforcement by the judiciary in different jurisdictions has started to normalize a doctrine that was considered controversial and extraordinary. This paper seeks to cast some doubts on the use of this doctrine, especially when the Court that enforces it is the subject of the amendment itself. In the first section it will question the conceptual foundations of the doctrine by recourse to legal theory, focusing not only on the idea of constituent power, but also on those of the rule of law and accountability. In the second section, some comparative cases of unconstitutional constitutional amendments will be analyzed, focusing on those where the judiciary itself was the subject of the amendment. Finally, from a normative and conceptual standpoint, a dialogic approach to the application of the doctrine will be proposed, to mitigate the fact that Constitutional Courts can become an unaccountable accountability-holder.
In Search of a Standard: References to the Rule of Law in the Case-law of the European Court of Human Rights
Authors: Polgári Eszter 
Published: September 2020

Abstract
The present article maps the explicit references to the rule of law in the jurisprudence of the ECtHR by examining the judgments of the Grand Chamber and the Plenary Court. On the basis of the structured analysis it seeks to identify the constitutive elements of the Court’s rule of law concept and contrast it with the author’s working definition and the position of other Council of Europe organs. The review of the case-law indicates that the Court primarily associates the rule of law with access to court, judicial safeguards, legality and democracy, and it follows a moderately thick definition of the concept including formal, procedural and some substantive elements. The rule of law references are predominantly ancillary arguments giving weight to other Convention-based considerations and it is not applied as a self-standing standard.
Study of electric field stress on the surface contour and at the triple junction in three phase GIS with FGM spacer under the depression defect
Authors: Pakalapati Janaki , Gundavarapu Venkata N. Kumar , Duvvada Deepak Chowdary , Bali Sravana Kumar 
Published: September 2020

Abstract
Now days, the establishment of spacers is in wide usage in three-phase Gas Insulated Busduct (GIB) for providing mechanical support and better insulation to the conductors. The region of the intersection of SF6 gas, enclosure end and the spacer is one of the weakest links in GIB, so the major concentration is done on minimization of electric field stress at this junction by using Functionally Graded Material (FGM) technique. The other incidents of insulation failures are due to several defects like depression, delamination etc. reduces the dielectric strength of the spacers. In this paper, an FGM post type spacer has been designed for a three-phase GIB under depression and further electric field stress at Triple Junction (TJ) is reduced by introducing a metal insert (MI) nearer to the TJ. Several filler materials are used as doping materials for obtaining different permittivity values using FGM technique to achieve uniform electric field stress. Simulation is carried out for the designed spacer at various operating voltages with different types of FGM gradings. The effect of depression with different dimensions and positions is analyzed before and after inserting MI to the FGM post type spacer in three-phase GIB.
D-linked and non-d-linkedwh-questions in L2 French and L3 English
Authors: Hermas Abdelkader 
Published: September 2020

AbstractThis study considers L2 French and L3 English ultimate attainment among L1 Moroccan Arabic adult learners. It contrasts the acquisition of two types ofwh-questions: discourse-linked and non-discourse-linked questions in root and embedded forms. The results of two acceptability judgment tasks indicate that the advanced learners in L2 French and L3 English are nativelike on d-linkedwh-questions but less accurate on non-discourse-linked interrogatives. They successfully unlearn resumption as an L1 strategy to form discourse-linked questions. Therefore, contra the prediction of the Interface Hypothesis, discourse-linking is acquirable though it is a property of the syntax-discourse interface. It does not pose more learning difficulty than quantification (formalwh-feature) of narrow syntax. The study indicates that embedding and thereby the processing cognitive load are the deterministic variables, not the language domain of constructions.
Mannose-binding lectin (MBL) and the lectin complement pathway play a role in cutaneous ischemia and reperfusion injury
Authors: Peck Claas-Tido , Strauß Sarah , Stahl Gregory L. , Vogt Peter-Maria , Busche Marc N. 
Published: September 2020

Abstract

Objectives
Cutaneous ischemia/reperfusion (CI/R) injury has shown to play a significant role in chronic wounds such as decubitus ulcers, diabetic foot ulcers, atherosclerotic lesions, and venous stasis wounds. CI/R also plays a role in free tissue transfer in reconstructive microsurgery and has been linked to clinical burn-depth progression after thermal injury. While the role of the complement system has been elucidated in multiple organ systems, evidence is lacking with respect to its role in the skin. Therefore, we evaluated the role of the complement system in CI/R injury.

Methods
Using a single pedicle skin flap mouse model of acute CI/R, we performed CI/R in wild-type (WT) mice and complement knock out (KO) mice, deficient in either C1q (C1q KO; classical pathway inhibition), mannose-binding lectin (MBL null; lectin pathway inhibition) or factor B (H2Bf KO; alternative pathway inhibition). Following 10 h ischemia and 7 days reperfusion, mice were sacrificed, flaps harvested and flap viability assessed via Image J software. The flap necrotic area was expressed as % total flap area. In another group, mice were sacrificed following CI/R with 10 h ischemia and 48 h reperfusion. Two cranial skin flap samples were taken for gene expression analysis of IL1b, IL6, TNFα, ICAM1, VCAM1, IL10, IL13 using real-time polymerase chain reaction (RT-PCR).

Results
Following CI/R, MBL null mice had a statistically significant smaller %necrotic flap area compared to WT mice (10.6 vs. 43.1%; p<0.05) suggesting protection from CI/R. A significantly reduced mean %necrotic flap area was not seen in either C1q KO or H2Bf KO mice relative to WT (22.9 and 31.3 vs. 43.1%; p=0.08 and p=0.244, respectively). There were no statistically significant differences between groups for markers of inflammation (TNFα, ICAM1, VCAM1, IL1b, IL6). In contrast, mRNA levels of IL10, a regulator of inflammation, were significantly increased in the MBL null group (p=0.047).

Conclusions
We demonstrated for the first time a significant role of MBL and the lectin complement pathway in ischemia/reperfusion injury of the skin and a potential role for IL10 in attenuating CI/R injury, as IL10 levels were significantly increased in the tissue from the CI/R-protected MBL null group.
Averaging causal estimators in high dimensions
Authors: Antonelli Joseph , Cefalu Matthew 
Published: September 2020

Abstract
There has been increasing interest in recent years in the development of approaches to estimate causal effects when the number of potential confounders is prohibitively large. This growth in interest has led to a number of potential estimators one could use in this setting. Each of these estimators has different operating characteristics, and it is unlikely that one estimator will outperform all others across all possible scenarios. Coupling this with the fact that an analyst can never know which approach is best for their particular data, we propose a synthetic estimator that averages over a set of candidate estimators. Averaging is widely used in statistics for problems such as prediction, where there are many possible models, and averaging can improve performance and increase robustness to using incorrect models. We show that these ideas carry over into the estimation of causal effects in high-dimensional scenarios. We show theoretically that averaging provides robustness against choosing a bad model, and show empirically via simulation that the averaging estimator performs quite well, and in most cases nearly as well as the best among all possible candidate estimators. Finally, we illustrate these ideas in an environmental wide association study and see that averaging provides the largest benefit in the more difficult scenarios that have large numbers of confounders.
On the clustering of stationary points of Tikhonov’s functional for conditionally well-posed inverse problems
Authors: Kokurin Mikhail Y. 
Published: September 2020

Abstract
In a Hilbert space, we consider a class of conditionally well-posed inverse problems for which the Hölder type estimate of conditional stability on a bounded closed and convex subset holds.
We investigate a finite-dimensional version of Tikhonov’s scheme in which the discretized Tikhonov’s functional is minimized over the finite-dimensional section of the set of conditional stability.
For this optimization problem, we prove that each its stationary point that is located not too far from the desired solution of the original inverse problem in reality belongs to a small neighborhood of the solution.
Estimates for the diameter of this neighborhood in terms of discretization errors and error level in input data are also given.
Soft computing based compressive sensing techniques in signal processing: A comprehensive review
Authors: Mishra Ishani , Jain Sanjay 
Published: September 2020

AbstractIn this modern world, a massive amount of data is processed and broadcasted daily. This includes the use of high energy, massive use of memory space, and increased power use. In a few applications, for example, image processing, signal processing, and possession of data signals, etc., the signals included can be viewed as light in a few spaces. The compressive sensing theory could be an appropriate contender to manage these limitations. “Compressive Sensing theory” preserves extremely helpful while signals are sparse or compressible. It very well may be utilized to recoup light or compressive signals with less estimation than customary strategies. Two issues must be addressed by CS: plan of the estimation framework and advancement of a proficient sparse recovery calculation. The essential intention of this work expects to audit a few ideas and utilizations of compressive sensing and to give an overview of the most significant sparse recovery calculations from every class. The exhibition of acquisition and reconstruction strategies is examined regarding the Compression Ratio, Reconstruction Accuracy, Mean Square Error, and so on.
Liraglutide pharmacokinetics and exposure-response in pediatric patients with type 2 diabetes
Authors: Petri Kristin C. C. , Hale Paula M. , Hofman Paul L. , Jacobsen Lisbeth V. 
Published: September 2020

Abstract

Objectives
Based on the ellipse trial, liraglutide was recently approved for use in pediatric patients with type 2 diabetes. We report the comparative exposure of liraglutide in pediatric vs. adult patients.

Methods
In this pharmacokinetic (PK) and exposure-response meta-analysis, data from two pediatric trials (including ellipse) and two adult trials of liraglutide were compiled (1,137 PK observations from 116 patients) to determine the impact of body weight, age and sex on liraglutide exposure. The exposure-response relationship for glycated hemoglobin (HbA1c) and body weight was compared between pediatric and adult patients. Additionally, the relationships between exposure and change from baseline in body mass index (BMI) and BMI standard deviation score (SDS) were assessed.

Results
The same liraglutide dose showed comparable exposure levels in pediatric and adult patients. Body weight and sex were the most important covariates for liraglutide exposure. There was an increasing response with higher liraglutide concentrations, and greater reductions were observed from baseline in HbA1c at 26 weeks vs. placebo. A trend toward lower body weight, BMI and BMI SDS was observed at 26 weeks.

Conclusions
These results support use of the same liraglutide dosing regimen in children and adolescents, aged ≥10 years, as that used in adults.
Bacterial stability with freezer storage of human milk
Authors: Pandya Shachee P. , Doshi Harshit , Codipilly Champa N. , Fireizen Yaron , Potak Debra , Schanler Richard J. 
Published: September 2020

Abstract

Objectives
Human milk supports the development of a beneficial newborn intestinal microflora. We have shown previously that human milk had reduced bacteria but unchanged nutrient composition when stored at −20 °C for up to nine months. We suspected declining bacterial colony counts were manifestations of bacterial dormancy and not failure of survival. We investigated differences in selected bacterial colony counts (lactobacillus, bifidobacteria, staphylococcus, streptococcus and enterococcus) in human milk stored for 2 and 12 weeks at −20 °C in either manual or automatic defrost freezers and whether reduced bacterial counts at 12 weeks were the result of dormancy or failure of survival.

Methods
Freshly expressed milk was obtained from mothers in the NICU, divided into aliquots and stored for 2 and 12 weeks at −20 °C in either automatic or manual defrost freezers. Subsequently, duplicate aliquots, one thawed and the other thawed and maintained at room temperature for 4 h, were plated to assess bacterial colony counts.

Results
Significant declines in bacterial colony counts were seen from 2 to 12 weeks freezer storage for all bacteria. There were no differences in colony counts between freezer types. Once thawed, no further bacterial growth occurred.

Conclusions
Short-term freezer storage for 12 weeks resulted bacterial killing. Type of freezer used for storage did not have an impact on bacterial survival. It is unknown whether the paucity of important probiotic bacteria in stored human milk has adverse effects on infants.
Eduard von Hartmann, die Postulatenlehre und die Genese des Neukantianismus im Kontext spiritistischer Debatten um 1900
Authors: Heidenreich Hauke 
Published: September 2020

AbstractMost scholars dealing with neo-Kantianism emphasize the existence of an explicit origin that characterizes neo-Kantianism as a clearly defined ‘movement’ with certain objects. In spite of the fact that differences between various neo-Kantian authors are mentioned in the current discourse (e. g. ‘Südwestdeutsche’ and ‘Marburger Schule’) scholars claim a singular unity of all neo-Kantian debates represented in the problem of ‘Geltung’. This is used to construct a certain relevance of neo-Kantianism in today’s philosophy.My contribution will pursue a historical approach following Klaus Christian Köhnke’s and Ulrich Sieg’s demands. Instead of sketching systematic topics I pay further attention to the context in which an essence of neo-Kantianism was claimed or rejected. In doing so I will examine the discussions on the doctrine of postulates in Kant’s philosophy mainly led by Hans Vaihinger’s ‘Philosophy of As If’ and the impact of Eduard von Hartmann on the genesis of neo-Kantianism. I conclude that the definition of a consistent neo-Kantian ‘movement’ was an effect of rejecting spiritualist interpretations of the doctrine of postulates and in the following a rejection of the whole doctrine as ‘mysticism’ in canonical Kant interpretations.
Computer-aided diagnosis of skin cancer based on soft computing techniques
Authors: Xu Zhiying , Sheykhahmad Fatima Rashid , Ghadimi Noradin , Razmjooy Navid 
Published: September 2020

AbstractSkin cancer is a type of disease in which malignant cells are formed in skin tissues. However, skin cancer is a dangerous disease, and an early detection of this disease helps the therapists to cure this disease. In the present research, an automatic computer-aided method is presented for the early diagnosis of skin cancer. After image noise reduction based on median filter in the first stage, a new image segmentation based on the convolutional neural network optimized by satin bowerbird optimization (SBO) has been adopted and its efficiency has been indicated by the confusion matrix. Then, feature extraction is performed to extract the useful information from the segmented image. An optimized feature selection based on the SBO algorithm is also applied to prune excessive information. Finally, a support vector machine classifier is used to categorize the processed image into the following two groups: cancerous and healthy cases. Simulations have been performed of the American Cancer Society database, and the results have been compared with ten different methods from the literature to investigate the performance of the system in terms of accuracy, sensitivity, negative predictive value, specificity, and positive predictive value.
The crystal structure of dimethylammonium catena-[di(μ-aqua)-bis(μ9-benzene-1,3,5-tricarboxylato)pentalithium], C20H16Li5NO13
Authors: Li Ying , Qin Yu-Cai , Chen Bao-Kuan 
Published: September 2020

Abstract
C20H16Li5NO13, orthorhombic, Pnma (no. 62), a = 9.9218(8) Å, b = 14.6941(11) Å, c = 13.5697(10) Å, V = 1978.4(3) Å3, Z = 4, R
gt(F) = 0.0439, wR
ref(F
2) = 0.0960, T = 173(2) K.