bluuebunny/crossref_metadata_2025_split huggingface dataset:
Language network reorganization before and after temporal lobe epilepsy surgery
Authors: Foesleitner Olivia , Sigl Benjamin , Schmidbauer Victor , Nenning Karl-Heinz , Pataraia Ekaterina , Bartha-Doering Lisa , Baumgartner Christoph , Pirker Susanne , Moser Doris , Schwarz Michelle , Hainfellner Johannes A. , Czech Thomas , Dorfer Christian , Langs Georg , Prayer Daniela , Bonelli Silvia , Kasprian Gregor 
Published: September 2020

OBJECTIVE
Epilepsy surgery is the recommended treatment option for patients with drug-resistant temporal lobe epilepsy (TLE). This method offers a good chance of seizure freedom but carries a considerable risk of postoperative language impairment. The extremely variable neurocognitive profiles in surgical epilepsy patients cannot be fully explained by extent of resection, fiber integrity, or current task-based functional MRI (fMRI). In this study, the authors aimed to investigate pathology- and surgery-triggered language organization in TLE by using fMRI activation and network analysis as well as considering structural and neuropsychological measures.

METHODS
Twenty-eight patients with unilateral TLE (16 right, 12 left) underwent T1-weighted imaging, diffusion tensor imaging, and task-based language fMRI pre- and postoperatively (n = 15 anterior temporal lobectomy, n = 11 selective amygdalohippocampectomy, n = 2 focal resection). Twenty-two healthy subjects served as the control cohort. Functional connectivity, activation maps, and laterality indices for language dominance were analyzed from fMRI data. Postoperative fractional anisotropy values of 7 major tracts were calculated. Naming, semantic, and phonematic verbal fluency scores before and after surgery were correlated with imaging parameters.

RESULTS
fMRI network analysis revealed widespread, bihemispheric alterations in language architecture that were not captured by activation analysis. These network changes were found preoperatively and proceeded after surgery with characteristic patterns in the left and right TLEs. Ipsilesional fronto-temporal connectivity decreased in both left and right TLE. In left TLE specifically, preoperative atypical language dominance predicted better postoperative verbal fluency and naming function. In right TLE, left frontal language dominance correlated with good semantic verbal fluency before and after surgery, and left fronto-temporal language laterality predicted good naming outcome. Ongoing seizures after surgery (Engel classes ID–IV) were associated with naming deterioration irrespective of seizure side. Functional findings were not explained by the extent of resection or integrity of major white matter tracts.

CONCLUSIONS
Functional connectivity analysis contributes unique insight into bihemispheric remodeling processes of language networks after epilepsy surgery, with characteristic findings in left and right TLE. Presurgical contralateral language recruitment is associated with better postsurgical language outcome in left and right TLE.
A data-driven model to identify high-risk aneurysms and guide management decisions: the Rupture Resemblance Score
Authors: Rajabzadeh-Oghaz Hamidreza , Waqas Muhammad , Veeturi Sricharan S. , Vakharia Kunal , Tso Michael K. , Snyder Kenneth V. , Davies Jason M. , Siddiqui Adnan H. , Levy Elad I. , Meng Hui 
Published: September 2020

OBJECTIVE
Previous studies have found that ruptured intracranial aneurysms (RIAs) have distinct morphological and hemodynamic characteristics, including higher size ratio and oscillatory shear index and lower wall shear stress. Unruptured intracranial aneurysms (UIAs) that possess similar characteristics to RIAs may be at a higher risk of rupture than those UIAs that do not. The authors previously developed the Rupture Resemblance Score (RRS), a data-driven computer model that can objectively gauge the similarity of UIAs to RIAs in terms of morphology and hemodynamics. The authors aimed to explore the clinical utility of RRS in guiding the management of UIAs, especially for challenging cases such as small UIAs.

METHODS
Between September 2018 and June 2019, the authors retrospectively collected consecutive challenging cases of incidentally identified UIAs that were discussed during their weekly multidisciplinary neurovascular conference. From patient 3D digital subtraction angiography, they reconstructed the aneurysm geometry and performed computer-assisted 3D morphology analysis and computational fluid dynamics simulation. They calculated RRS for every UIA case and compared it against the treatment decision made at the neurovascular conference as well as the recommendation based on the unruptured intracranial aneurysm treatment score (UIATS).

RESULTS
Forty-seven patients with 79 UIAs, 90% of which were < 7 mm in size, were included in this study. The mean RRS (range 0.0–1.0) was 0.24 ± 0.31. At the conferences, treatment was endorsed for 45 of the UIAs (57%). These cases had significantly higher RRSs than the 34 cases suggested for observation (0.33 ± 0.34 vs 0.11 ± 0.19, p < 0.001). The UIATS-based recommendations were “observation” for 24 UIAs (30%), “treatment” for 21 UIAs (27%), and “not definitive” for 34 UIAs (43%). These “not definitive” cases were stratified by RRS based on similarity to RIAs.

CONCLUSIONS
Although not a rupture predictor, RRS is a data-driven model that gauges the similarity of UIAs to RIAs in terms of morphology and hemodynamics. In cases in which the UIATS-based recommendation is not definitive, RRS provides additional stratification to assist the identification of high-risk UIAs. The current study highlights the clinical utility of RRS in a real-world setting as an adjunctive tool for the management of UIAs.
Procalcitonin in the context of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
Authors: Veldeman Michael , Lepore Daniel , Höllig Anke , Clusmann Hans , Stoppe Christian , Schubert Gerrit Alexander , Albanna Walid 
Published: September 2020

OBJECTIVE
Aneurysmal subarachnoid hemorrhage (aSAH) initiates a deleterious cascade activating multiple inflammatory processes, which can contribute to delayed cerebral ischemia (DCI). Procalcitonin (PCT) is an established marker for sepsis treatment monitoring, and its time course in the context of DCI after aSAH remains unclear. The aim of this trial was to assess the predictive and confirmative value of PCT levels in the context of DCI.

METHODS
All patients admitted to the authors’ institution with aSAH between 2014 and 2018 were prospectively screened for eligibility. Daily PCT levels were recorded alongside relevant aSAH characteristics. The predictive and confirmative values of PCT levels were assessed using a receiver operating characteristic and area under the curve (AUC) analysis. The course of PCT levels around the DCI event was evaluated in an infection-free subgroup of patients.

RESULTS
A total of 132 patients with aSAH were included. Early PCT levels (first 3 days post-aSAH) had a low predictive value for the development of DCI (AUC 0.661, standard error [SE] 0.050; p = 0.003) and unfavorable long-term outcome (i.e., Glasgow Outcome Scale–Extended scores 1–4; AUC 0.674, SE 0.054; p = 0.003). In a subgroup analysis of infection-free patients (n = 72), PCT levels were higher in patients developing DCI (p = 0.001) and DCI-related cerebral infarction (p = 0.002). PCT concentrations increased gradually after DCI and decreased with successful intervention. In refractory cases progressing to cerebral infarction, PCT levels showed a secondary increase.

CONCLUSIONS
Early higher PCT levels were associated with the later development of DCI and unfavorable outcome. Analysis of PCT beyond the first couple of days after hemorrhage is hampered by nosocomial infections. In infection-free patients, however, PCT levels rise during DCI and an additional increase develops in patients developing cerebral infarction.
Clinical trial registration no.: NCT02142166 (clinicaltrials.gov)
The management of clival chordomas: an Italian multicentric study
Authors: Cavallo Luigi Maria , Mazzatenta Diego , d’Avella Elena , Catapano Domenico , Fontanella Marco Maria , Locatelli Davide , Luglietto Davide , Milani Davide , Solari Domenico , Vindigni Marco , Zenga Francesco , Zona Gianluigi , Cappabianca Paolo 
Published: September 2020

OBJECTIVE
In the last 2 decades, the endoscopic endonasal approach in the treatment of clival chordomas has evolved to be a viable strategy to achieve maximal safe resection of this tumor. Here, the authors present a multicentric national study, intending to analyze the evolution of this approach over a 20-year time frame and its contribution in the treatment of clival chordomas.

METHODS
Clival chordoma cases surgically treated between 1999 and 2018 at 10 Italian neurosurgical departments were included in this retrospective study. Clinical, radiological, and surgical findings, adjuvant therapy, and outcomes were evaluated and compared according to classification in the treatment eras from 1999 to 2008 and from 2009 to 2018.

RESULTS
One hundred eighty-two surgical procedures were reviewed, with an increase in case load since 2009. The endoscopic endonasal transclival approach (EETA) was performed in 151 of 182 cases (83.0%) and other approaches were performed in 31 cases (17%). There was an increment in the use of EETA, neuronavigation, and Doppler ultrasound after 2008. The overall postoperative complication rate was 14.3% (26 of 182 cases) consisting of 9 CSF leaks (4.9%), 7 intracranial hemorrhages (3.8%), 5 cases of meningitis (2.7%), and 5 cerebral ischemic injuries (2.7%). Gross-total resection (GTR) was achieved in 93 of 182 cases (51.1%). Extent of resection (EOR) improved in the second era of the study. Signs and/or symptoms at presentation worsened in 27 cases (14.8%), and the Katz Index worsened in 10 cases (5.5%). Previous treatment, dural involvement, EETA, and intraoperative Doppler ultrasound correlated with GTR. Patients received adjuvant proton beam radiation in 115 of 182 cases (63.2%), which was administered more in the latter era. Five-year progression-free survival (PFS) and overall survival (OS) were 62.3% and 73.5%, respectively. GTR, EETA, proton beam therapy, and the chondroid subtype correlated with a better survival rate. The mean follow-up was 62 months.

CONCLUSIONS
Through multicentric data collection, this study encompasses the largest series in the literature of clival chordomas surgically treated through an EETA. An increase in the use of this approach was found among Italian neurosurgical departments together with an improved extent of resection over time. The satisfactory rate of GTR was marked by low surgical morbidity and the preservation of patient quality of life. Surgical outcome was reinforced, in terms of PFS and OS, by the use of proton beam therapy, which was increasingly performed along the period of study.
Problematika Pemilihan Kepala Daerah Calon Tunggal Dalam Demokrasi Indonesia
Authors: Ishak Nurfaika 
Published: September 2020

<p><em>This study aims to explain the arrangements for a single candidate regional head election and how people's sovereignty is channeled into the democratic process of regional head elections. This type of research is a descriptive normative juridical study. The data used are secondary data in the form of primary legal materials and secondary legal materials obtained through literature study. The results showed that the regulation of regional head elections with only 1 (one) pair of candidates began with the issuance of the Constitutional Court decision Number 100 / PUU-XIII / 2015 which was subsequently followed by the issuance of General Election Commission Regulation Number 14 of 2015 and Law Number 10 of 2016. Whereas the people are the determinants of government administration power through the regional head election process so that the people as the main activator of the wheel of democracy should not be hindered in choosing candidates for regional head leaders even though there is only one pair of candidates involved in the election. Election of heads must be carried out honestly and fairly so that political awareness by all citizens can be realized.</em></p><p><strong><em>Keywords: </em></strong><em>Local Elections; Sovereignty; Democracy.</em></p>
Feasibility study of detecting the end contacting status of threaded-sleeve-connected reinforcing bar using magnetostrictive guided wave
Authors: Hu Chaoyue , Xu Jiang , Li Yunfei 
Published: September 2020

The reinforcing bar connected by threaded sleeve is widely used. The end contacting status under the sleeve indicates the tightness of the threaded sleeve connection. In this paper, the feasibility of using magnetostrictive guided wave to detect the end contacting status of the reinforcing bar is studied. Firstly, the propagation characteristic of the wave propagating through the threaded sleeve connection is analyzed. The end contacting status affects the reflection and transmission of the wave. Then, experiments are carried out on a thread-sleeve-connected reinforcing bar. The passing signals of the threaded sleeve connection at an exciting frequency of 30 kHz can be used to distinguish end contacting status of the reinforcing bar. Additionally, the peak voltage of the passing signal’s first passing wave decreases with the increasing loosening angle of the threaded sleeve connection. The study proves the feasibility of detecting the end contacting status using magnetostrictive guided wave.
Micro-power-generator for energy harvesting from vortex induced vibration
Authors: Chen Yuansheng , Gu Cong , Wang Hao , Qiu Jinhao , Zhao Sunchong 
Published: September 2020

A micro-power-generator is developed with piezoelectric ceramics, which can convert the structural vibration energy generated by wind power into electricity to provide energy for micro-devices such as wireless sensor nodes. The vibration modes of the device are analyzed. The standard interface circuit for piezoelectric energy recovery and LTC3588-1 voltage stabilization circuit are selected, and the hardware circuit of the device is designed. The output voltage and power characteristics of micro-power-generator were analyzed under different loads, frequencies and amplitudes. The experimental results show that under the same wind speed, When the blunt body is a cuboid, the power generation effect of this device is the best under the optimal load, with the maximum output power of 350.7 μW. Under the same load with the same shape and structure, the load voltage and output power increase with the increase of wind speed.
Performance analysis of magnetic gear with Halbach array for high power and high speed
Authors: Kim Se-Yeong , Lee Tae-Woo , Chun Yon-Do , Hong Do-Kwan 
Published: September 2020

In this study, we propose a non-contact 80 kW, 60,000 rpm coaxial magnetic gear (CMG) model for high speed and high power applications. Two models with the same power but different radial and axial sizes were optimized using response surface methodology. Both models employed a Halbach array to increase torque. Also, an edge fillet was applied to the radial magnetized permanent magnet to reduce torque ripple, and an axial gap was applied to the permanent magnet with a radial gap to reduce eddy current loss. The models were analyzed using 2-D and 3-D finite element analysis. The torque, torque ripple and eddy current loss were compared in both models according to the materials used, including Sm2Co17, NdFeBs (N42SH, N48SH). Also, the structural stability of the pole piece structure was investigated by forced vibration analysis. Critical speed results from rotordynamics analysis are also presented.
Numerical and experimental analysis of turbulent boundary layer control with piezo-ceramic actuator
Authors: Li Dawei , Li Guijuan , Sun Lin , Chen Yunfei 
Published: September 2020

The effects of smart-material-based active surface perturbation (i.e. piezo-ceramic actuators) on wall shear stress and noise metric have been investigated by simulations and wind tunnel experiments. A periodic vibration through the application of piezo-ceramic actuators is imposed on the surface of a plate, and the vibration position is located on the upper part of the leading edge of the plate. Both the control results from simulations and experiments are close to each other, when the control parameters are the same. The simulations and wind tunnel experiments show that downstream skin-friction drag and noise metric can be reduced with the active control, and the reductions strongly depend on control parameters. Comparing with the near wall flow structures, the turbulent kinetic energy and characteristic turbulence length scale in the turbulent boundary layer can be controlled with the piezo-ceramic actuator.
Accuracy of parent-reported ages and stages questionnaire in assessing the motor and language skills of preterm infants
Authors: Hwarng G. Y. H. , Ereno I. L. , Ho S. K. Y. , Allen J. C. , Moorakonda R. B. , Yeo C. L. 
Published: September 2020

BACKGROUND: Parent-completed tools like the Ages and Stages Questionnaire Third Edition (ASQ-3) are important in developmental screening. As a screening tool, a high negative predictive value (NPV) is critical to avoid missing the diagnosis of developmental delay. This study evaluated the NPV and accuracy of the ASQ-3 in assessing the development of preterm infants. METHODS: Infants born at <32 weeks and/or <1250 grams, presenting to the Neonatal Neurodevelopmental Clinic at the Singapore General Hospital for follow-up from January 2014 to June 2017, at 6, 12, and 18 months corrected age, were included. The ASQ-3 and standardized tests – Peabody Developmental Motor Scale-Second Edition (PDMS-2) and Preschool Language Scale, Fourth Edition UK (PLS-4 UK) – were administered. ASQ-3 gross motor and fine motor scores were compared to PDMS-2 at 6 and 12 months, and ASQ-3 communication scores to PLS-4 UK at 18 months. RESULTS: At 6 months ( n = 145), NPV for gross motor and fine motor were 96.4% (accuracy 80.0%) and 95.4% (accuracy 77.2%) respectively. At 12 months ( n = 127), NPV for gross motor and fine motor were 88.9% (accuracy 79.8%) and 82.8% (accuracy 74.0%) respectively. At 18 months ( n = 113), NPV for language was 56.9% (accuracy 63.7%). CONCLUSIONS: The ASQ-3 showed high NPV and accuracy in screening gross motor and fine motor skills at 6 and 12 months, but not in screening language skills at 18 months. Judicious use of the ASQ-3 may allow for more effective utilization of resources.
Generating and characterizing the anti-human CD45 monoclonal antibody
Authors: Ta Giang Huong , Nguyen Huy Quoc , Nguyen Quan Dang 
Published: September 2020

Introduction: CD45 is a common marker of leukocytes. Anti-human CD45 monoclonal antibody (MAb) has been used widely in diagnosing and monitoring hematologic diseases. The aim of this study was to generate an anti-human CD45 MAb, which can be used in research and diagnosis.
Methods: Recombinant human CD45RO antigen was expressed from E. coli BL21 (DE3), purified and analyzed by SDS-PAGE and Western blotting. The purified CD45RO antigen was used to immunize Balb/c mice. Spleen cells from immunized mouse were collected and fused with P3X63Ag8.653 myeloma cells to form hybridoma. Anti-CD45 antibody-secreting capacity of hybridoma clones was evaluated by ELISA assay. Anti-CD45 MAb from the culture supernatant of the chosen hybridoma clone was purified by affinity chromatography. The MAb was characterized the biochemical characteristics and biological activity.
Results: Recombinant human CD45RO antigen was expressed and purified from E.coli BL21 (DE3). Injection of purified CD45RO antigen provoked the immune response in Balb/c mice. Hybridoma clones were generated successfully by the fusion of spleen cells from the selected immunized-mouse and myeloma cells. Among these hybridoma clones, one with the highest yield of MAb production was identified. The isotype of the anti-CD45 MAb created in this work is IgG2b, while its the light chain is kappa (k) type. The affinity of this MAb with CD45RO antigen is high with Kd value at the picomolar level. The anti-CD45 MAb can interact with CD45 naturally expressed on the surface of Jurkat cells in Western blotting and fluorescent immuno-staining assay.
Conclusion: We have developed successfully an anti-human CD45 MAb using hybridoma technology, which can recognize CD45 in ELISA, Western blotting, and fluorescent immuno-staining analysis. Although further investigations are necessary, obviously, our anti-human CD45 MAb is potential for research and diagnosis applications.
Analisa Sisa Material Konstruksi Pada Kegiatan Pembangunan Mesjid
Authors: Dwiretnani Annisaa , Amalia Kiki Rizky , A.K Alfiando Wijaya 
Published: September 2020

Sisa material konstruksi merupakan salah satu masalah serius pada pelaksanaan proyek. Adanya usaha meminimalkan hal tersebut turut membantu mengurangi dampak negatif terhadap lingkungan. Pada penelitian ini difokuskan pada kajian sisa material konstruksi untuk pekerjaan balok dan kolom pada Kegiatan Pembangunan Mesjid Komplek Perkantoran Walikota Jambi (Lanjutan). Penelitian dilakukan dengan menganalisa persentase sisa material konstruksi, persentase terbesar sisa material konstruksi dan faktor-faktor apa saja yang menjadi penyebab terjadinya sisa material konstruksi pekerjaan balok dan kolom pada Kegiatan Pembangunan Mesjid Komplek Perkantoran Walikota Jambi (Lanjutan). Persentase sisa material konstruksi pekerjaan balok dan kolom terbanyak adalah pasir, yakni sebanyak 33,33% atau setara dengan 2 m3.
The Libraries’ contributing to the Victory in the Great Patriotic War
Authors: Pleshkevich E. A. 
Published: September 2020

Review of the book: Mazuritsky A. M. Libraries in the years of Great Patriotic War: A learning guide. – Orel, 2020. – 139 p.The reviewed textbook introduces to the history of Russian librarianship during the Great Patriotic War. The structure of the manual is overviewed. The didactic analysis demonstrates the presentation logic which facilitates learning and is of great ethical educative value. In terms of scientific discussion, recommendations are given for further development of this subject scope to cover the following issues: 1) library support facilities for high morale and combative mood of the Red Army (the front-line and navy libraries); 2) library support of healing and bibliotherapy (hospital libraries); 3) library and information support of promising research and development projects (scientific and technical libraries of plants and factories); 4) libraries in the system of cultural, educational, moral and psychological support for the residents of blockaded Leningrad; 5) library support of high morale of the population and its faith in the victory over the enemy. The significance and relevance of the learning guide is emphasized. The reviewer recommends to prepare a textbook on the history of library construction during the Great Patriotic War.
A Case Report : Cardiac Tumour Mimicking Heart Failure
Authors: Low Qin Jian , Cheo Seng Wee 
Published: September 2020

Primary cardiac tumor are extremely rare. Incidence is approximately 0.017-0.019% of all primarytumor. An early diagnosis of cardiac tumor may improve the outcome.
Bangladesh J Medicine July 2020; 31(2) : 111-113