bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of tumor recurrence in intracranial meningiomas: comparative analyses of the predictive value of the postoperative tumor volume and the Simpson classification
Authors: Spille Dorothee Cäcilia , Hess Katharina , Bormann Eike , Sauerland Cristina , Brokinkel Caroline , Warneke Nils , Mawrin Christian , Paulus Werner , Stummer Walter , Brokinkel Benjamin 
Published: July 2020

OBJECTIVE
In meningiomas, the Simpson grading system is applied to estimate the risk of postoperative recurrence, but might suffer from bias and limited overview of the resection cavity. In contrast, the value of the postoperative tumor volume as an objective predictor of recurrence is largely unexplored. The objective of this study was to compare the predictive value of residual tumor volume with the intraoperatively assessed extent of resection (EOR).

METHODS
The Simpson grade was determined in 939 patients after surgery for initially diagnosed intracranial meningioma. Tumor volume was measured on initial postoperative MRI within 6 months after surgery. Correlation between both variables and recurrence was compared using a tree-structured Cox regression model.

RESULTS
Recurrence correlated with Simpson grading (p = 0.003). In 423 patients (45%) with available imaging, residual tumor volume covered a broad range (0–78.5 cm3). MRI revealed tumor remnants in 8% after gross-total resection (Simpson grade I–III, range 0.12–33.5 cm3) with a Cohen’s kappa coefficient of 0.7153. Postoperative tumor volume was correlated with recurrence in univariate analysis (HR 1.05 per cm3, 95% CI 1.02–1.08 per cm3, p < 0.001). A tree-structured Cox regression model revealed any postoperative tumor volume > 0 cm3 as a critical cutoff value for the prediction of relapse. Multivariate analysis confirmed the postoperative tumor volume (HR 1.05, p < 0.001) but not the Simpson grading (p = 0.398) as a predictor for recurrence.

CONCLUSIONS
EOR according to Simpson grading was overrated in 8% of tumors compared to postoperative imaging. Because the predictive value of postoperative imaging is superior to the Simpson grade, any residual tumor should be carefully considered during postoperative care of meningioma patients.
The neurosurgery residency interview: assessing applicant perspectives on question content, utility, and stress
Authors: Zuckerman Scott L. , Limoges Natalie , Yengo-Kahn Aaron M. , Graffeo Christopher S. , Chambless Lola B. , Chitale Rohan , Mocco J , Durham Susan 
Published: July 2020

OBJECTIVE
Residency interviews are integral to the recruitment process yet imperfect. Through surveys of neurosurgery residency applicants, the authors describe interview content and the perceived utility and stress of topics from the applicant’s perspective.

METHODS
All 2018–2019 neurosurgery resident applicants applying to three particular programs were surveyed. Across 10 interview topics, survey questions assessed topic frequency and the applicant’s opinion of the utility and stress of each topic (Likert scale 1–5). Analyses included descriptive statistics, Spearman’s rank correlation, and logistic regression.

RESULTS
One hundred thirty-three of 265 surveyed US residency applicants (50%) responded. Extracurricular activities, research, future career, non-medicine interests, and small talk were discussed in all interviews. The least frequent topics included neurosurgical knowledge assessment (79%) and manual dexterity tests (45%). The most useful topics according to respondents were future career objectives (4.78 ± 0.49) and prior research (4.76 ± 0.50); the least useful were neurosurgical knowledge assessment (2.67 ± 1.09) and manual dexterity tests (2.95 ± 1.05). The most stressful topics were neurosurgical knowledge assessment (3.66 ± 1.23) and ethical/behavioral scenarios (2.94 ± 1.28). The utility and stress of manual dexterity tests and neurosurgical knowledge assessments were inversely correlated (r = −0.40, p < 0.01; r = −0.36, p < 0.01), whereas no such correlation existed for ethical/behavioral questions (r = −0.12, p = 0.18), indicating that ethical/behavioral questions may have been stressful but were potentially useful topics. Respondents who attended ≥ 15 interviews were more likely to be asked about the three most stressful topics (each p < 0.05). Respondents with children were less likely to be asked about ethical/behavioral scenarios (OR 0.13, 95% CI 0.03–0.52, p < 0.01).

CONCLUSIONS
Applicants found several of the most frequently discussed topics to be less useful, indicating a potential disconnect between applicant opinion and the faculty’s preferred questions. Ethical/behavioral scenarios were rated as stressful but still useful, representing a potentially worthwhile type of question. These data provide several avenues for potential standardization and improvement of the interview process.
Quantitative analysis of the correlation between preoperative cervical degeneration and postoperative heterotopic ossification after cervical disc replacement: minimum 10-year follow-up data
Authors: Zhou Feifei , Li Shuyang , Zhao Yanbin , Zhang Yilong , Ju Kevin L. , Zhang Fengshan , Pan Shengfa , Sun Yu 
Published: July 2020

OBJECTIVEThe authors aimed to identify factors that may be useful for quantifying the amount of degenerative change in preoperative patients to identify ideal candidates for cervical disc replacement (CDR) in patients with a minimum of 10 years of follow-up data.METHODSDuring the period from December 2003 to August 2008, 54 patients underwent CDR with a Bryan cervical disc prosthesis performed by the same group of surgeons, and all of the patients in this group with at least 10 years of follow-up data were enrolled in this retrospective analysis of cases. Postoperative bone formation was graded in radiographic images by using the McAfee classification for heterotopic ossification. Preoperative degeneration was evaluated in radiographs based on a quantitative scoring system. After univariate analysis, the authors performed multifactor logistic regression analysis to identify significant factors. To determine the cutoff points for the significant factors, a receiver operating characteristic (ROC) curve analysis was conducted.RESULTSStudy patients had a mean age of 43.6 years and an average follow-up period of 120.3 months. The patients as a group had a 68.2% overall incidence of bone formation. Based on univariate analysis results, data for patient sex, disc height, and the presence of anterior osteophytes and endplate sclerosis were included in the multivariate analysis. According to the analysis results, the identified independent risk factors for postoperative bone formation included disc height, the presence of anterior osteophytes, and endplate sclerosis, and according to a quantitative scoring system for degeneration of the cervical spine based on these variables, the ROC curve indicated that the optimal cutoff scores for these risk factors were 0.5, 1.5, and 1.5, respectively.CONCLUSIONSAmong the patients who were followed up for at least 10 years after CDR, the incidence of postoperative bone formation was relatively high. The study results indicate that the degree of degeneration in the target level before surgery has a positive correlation with the incidence of postoperative ossification. Rigorous indication criteria for postoperative ossification should be applied in patients for whom CDR may be a treatment option.
MENJAGA KESEHATAN MENTAL DENGAN PENDEKATAN SHALAT: ANALISIS SANAD DAN MATAN HADIS
Authors: Rama Wijaya Kesuma Wardhani Pasiska, Nurlaila Kamsi, 
Published: July 2020

Abstract
This paper seeks to open insight into the study of psychology that is in the Sunnah, regarding mental health. As one source of teachings in Islam, the Hadith contains information and knowledge, including mental health problems in the world of psychology today. With the approach of the study of sanad and matan hadith, the writer tries to explore texts that discuss the topic of mental health and its relevance in the hadith. then it can be concluded that 1) maintaining mental health in the perspective of the Sunnah based on the idea of ​​moderation in meeting the needs of life with a spirituality approach and, 2) the method of spiritual Hadith realizing mental health, among others by praying as a solution to mental illness. Achievements by the method of prayer can be seen from the lives of prophets and friends, with themselves, relationships with others, and the universe that all come together in harmony.
Comparison of chromatographic profiles of essential oils in extracts of 13 species from Lamiaceae family
Authors: Khohklova K. O. , Vyshnevska L. I. , Zdoryk O. A. 
Published: July 2020

The TLC essential oils profiles were being used conventionally for identification of herbal raw materials (HRM) of Lamiaceae family. Despite this, in recent years the European Pharmacopoeia to call in question the appropriateness of TLC on essential oils determination of Thyme and Wild Thyme, as well as Peppermint and Peppermint dry extract; these methods were replaced by HPTLC using ﬂavonoid proﬁle. This work aimed to establish the possibility of conducting HPTLC identification of methanolic extracts of 13 members of the Lamiaceae family in harmonized chromatographic conditions using chromatographic profiles on essential oils.
The objects were methanolic extracts of HRM of Ukraine flora – Salvia officinalis, Salvia aethiopis, Thymus serpyllum, Thymus vulgaris, Origanum vulgare, Rosmarinus officinalis, Ocimum tenuiflorum (foreign origin), Mentha × piperita, Melissa officinalis, Orthosiphon stamineus, Agastache foeniculum, Leonurus cardiaca, Hyssopus officinalis, Marrubium vulgare, prepared from HRM that were purchased in Ukraine. The study wоas done by standardized HPTLC procedure using automatic HPTLC herbal system of CAMAG, Switzerland, at the base of CAMAG laboratory, Muttenz, Switzerland, and laboratory of ESTCCTI ESIPP, NUPh, Ukraine. Chromatography conditions: stationary phase – HPTLC plates Si 60 F254; mobile phase – toluene-ethylacetate (95:5); reference standards – borneol, bornyl acetate, cineole; derivatization – anisaldehyde reagent; detection: WRT, 254, 366 nm – before derivatization; WRT, 366 nm – after derivatization; sample preparation – methanolic extracts (100 mg/ml), extracted by shaking technique.
In unified chromatographic conditions the HPTLC chromatographic fingerprints of essential oils of 13 Lamiaceae family species were established and evaluated. The most specific, intensive and reproducible HPTLC fingerprints were for Sage and Rosemary extracts. Moreover, fingerprints of Sage, Thyme, Rosemary, Origanum, Ocimum and Peppermint shown specific zones useful for differentiation of different genera of Lamiaceae family. For setting relative acceptance criteria for each of the species the validation for specific zones that were detected should be done.
KONSEP PENDIDIKAN SOSIAL DALAM AYAT-AYAT NAFKAH
Authors: Musthofa Musthofa , Pratama Arizqi Ihsan 
Published: July 2020

<p class="15bIsiAbstractBInggris">This research aims to formulate the concept of social education in the living verse contained in the Qur'an. The method of study used is a method of Tafsîr maudhû'î (thematic interpretation) to assess the concept of the living Qur'an, as well as a method of sociology to read its influence on the reality of social life of society. Implementation of the concept of social education in verses about living in the Qur'an will build a spirit of entrepreneurship, work ethic, business ethics, responsibilities, social care and victim attitudes. It can also create economic growth, revenue distribution, public services, jobs, eliminate poverty, slavery, consumptive behaviour and protect the public from the economic crisis.</p><p class="16aJudulAbstrak"><strong>Abstrak</strong></p><p class="16bIsiAbstrak">Penelitian ini berusaha merumuskan konsep pendidikan sosial dalam ayat-ayat nafkah yang terkandung di dalam Al-Qur’an. Metode penelitian yang digunakan adalah metode tafsîr maudhû’î (tafsir tematik) untuk mengkaji konsepsi nafkah Al-Qur’an, serta metode sosiologi untuk membaca pengaruhnya terhadap realita kehidupan sosial masyarakat. Implementasi konsep pendidikan sosial dalam ayat-ayat tentang nafkah dalam Al-Qur’an akan membangun semangat wirausaha, etos kerja, etika bisnis, tanggung jawab, kepedulian sosial dan sikap pengorbanan. Hal ini juga dapat menciptakan pertumbuhan ekonomi, distribusi pendapatan, pelayanan publik, lapangan kerja, menghilangkan kemiskinan, perbudakan, perilaku konsumtif dan melindungi masyarakat dari krisis ekonomi.</p>
Pengaruh Profitabilitas, Leverage, Komisaris Independen, Kepemilikan Institusional, dan Ukuran Perusahaan terhadap Penghindaran Pajak pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia pada Tahun 2014-2018
Authors: Sari Novita , Luthan Elvira , Syafriyeni Nini 
Published: July 2020

The biggest source of state income comes from taxes. So the Indonesian government continues to strive to improve tax revenue optimization measures to maximize revenue from the tax sector. But until now many citizens still consider tax as a burden. The company or entity still considers tax as an expense that will reduce the company's net profit. Taxpayers will tend to look for ways to reduce the tax they pay, both legally and illegally, one of which is the practice of tax avoidance Tax avoidance is a complex and unique problem because on one hand tax avoidance does not violate the law, on the other hand tax avoidance is not wanted by the government because it reduces income for the country. The purpose of this study is to analyze the effect of profitability, leverage, the proportion of independent commissioners, institutional ownership, and company size, on tax avoidance. The population of this research is the entire manufacturing company registered in indonesia stock exchange (BEI ) 2014-2018 during the period.A method of sampling nonprobability using methods with techniques of sampling purposive sampling .The technique of analysis of data using the test is the classic normality, multikolinieritas, heteroskedastisitas test, and autokorelasi test. Testing the hypothesis of the use of regression analysis double. The results of the study show that there is an influence between profitability and the proportion of independent commissioners on tax avoidance, while the variable leverage, institutional ownership and firm size do not show an influence on tax avoidance.
Heterozygous Urinary Abnormality–Causing Variants of COL4A3 and COL4A4 Affect Severity of Autosomal Recessive Alport Syndrome
Authors: Horinouchi Tomoko , Yamamura Tomohiko , Nagano China , Sakakibara Nana , Ishiko Shinya , Aoto Yuya , Rossanti Rini , Nakanishi Koichi , Shima Yuko , Morisada Naoya , Iijima Kazumoto , Nozu Kandai 
Published: July 2020

Background
Autosomal recessive Alport syndrome (ARAS) is an inherited renal disorder caused by homozygous and compound heterozygous mutations in COL4A3 or COL4A4, but the prognostic predictors for this disorder are not yet fully understood. Recently, the magnitude of the clinical spectrum of the COL4A3 and COL4A4 heterozygous state has attracted attention. This spectrum includes asymptomatic carriers of ARAS, benign familial hematuria, thin basement membrane disease, and autosomal dominant Alport syndrome.

Methods
We retrospectively analyzed 49 patients with ARAS from 41 families with a median age of 19 years to examine the clinical features and prognostic factors of ARAS, including the associated genotypes.

Results
The median age of patients with ARAS at ESKD onset was 27 years. There was no significant association between the presence or absence of hearing loss or truncating mutations and renal prognosis. However, there was a statistically significant correlation between renal prognosis and heterozygous variants that cause urinary abnormalities. Where the urinary abnormality–causing variant was absent or present in only one allele, the median age of ESKD onset was 45 years, whereas the same variant present on both alleles was associated with an age of onset of 15 years (P<0.001).

Conclusions
This study was the first to demonstrate the clinical importance in ARAS of focusing on variants in COL4A3 or COL4A4 that cause urinary abnormalities in both the homozygous or heterozygous state. Although heterozygous mutation carriers of COL4A3 and COL4A4 comprise a broad clinical spectrum, clinical information regarding each variant is important for predicting ARAS prognosis.
Content Test of Escherichia and Salmonella sp. Bacteria on Fish Sago in Dehigila Village, Morotai Island Regency
Authors: Asy’ari Asy’ari , Sofiati Titien , Wahab Iswandi , Sidin Jana 
Published: July 2020

Fish is one of the foodstuffs that has a protein content that is needed by humans. Nowadays fish have been processed into many products that have longer durability, humans have used fish as a mixture in diversified products. Diversification of fishery products so that fish can be used in other forms such as instant noodles, biscuits, and traditional products such as making sago plates mixed with fish meat. The purpose of this study was to determine the content of E. coli and Salmonella sp. on sago products produced. This research was conducted in September-October 2019. Sampling of fish sago was carried out in Dehegila Village, Morotai Island Regency. Sample analysis was performed at the Khairun University Ternate Environmental Laboratory. The data obtained were then presented in a descriptive analytic and literature study. From the results of the study obtained by sago plate added skipjack tuna meat as well as the use of flavorings Based on the analysis of all sago samples there was bacterial growth with an average number <0.30. While for Salmonella sp. on sago Ao and A1 negative / 25 g.
Desenvolvimento Pacífico Chinês frente à estratégia de “um século americano no Pacífico” / Chinese Pacific front development strategy "an American century in the Pacific"
Authors: Pires Marcos Cordeiro 
Published: July 2020

O objetivo deste artigo é o de refletir sobre o relacionamento entre Estados Unidos e China no século XXI. Ao se observar a evolução de indicadores econômicos, políticos e também militares, nota-se se que as trajetórias de Estados Unidos e China tendem a se cruzar, com um declínio relativo do primeiro e a rápida ascensão chinesa, o que nos leva a supor a ocorrência de uma possível disputa pela hegemonia mundial entre os dois países. Por conta disso, partimos do pressuposto de que a estratégia de “Um século americano na Ásia-Pacífico” se enquadra na tentativa de testar o compromisso chinês de “desenvolvimento pacífico” e seu comprometimento com a estabilidade das relações internacionais. ABSTRACTThe aim of this article is to reflect on the relationship between the United States and China in the 21th. Century. By observing trends of economic, political and also military indicators, we can note that the trajectories of the United States and China tend to cross, with a relative decline of the first and the fast Chinese rise. This situation makes us believe to suppose the occurrence of possible dispute for world hegemony between the two countries in medium and long term. Because of this, we assume that the strategy of "A American Century in Asia-Pacific" fits in an attempt to test the Chinese commitment to "peaceful development" and its guarantee of maintaining the stability of international relations.
Determination of Kinetic Parameters and The Effect of Ion Mg2+ Inhibition Into Pectinase Activities.
Authors: Anggraini Dian Puspita , Sulistiana Devita , Agustina Dwi Kameluh , Ulimaz Almira 
Published: July 2020

The purpose of study was to determine kinetic parameters and inhibitory effect of Mg2+ ions on pectinase. Activity test performed at pH 4,5 temperature 55oC for 50' with 10 mm concentrations of each ion 0-10mm. Galacturonic acid content, as product of pectin substrate hydrolysis, was used as basis for determining activity and analyzed by visible spectrophotometry. At concentrations 2 and 4 mm Mg2+ act as an activator, but at concentrations 6, 8, and 10 mM as inhibitors. The value of KM with and without inhibitors is almost same, that is 0.3145% and 0.3105% but value of Vm from both are different, that is 80,645 μg.ml-1.minute-1 and 62,112 μg.ml-1.minute-1. The conclusion that type of inhibitory pectinase with Mg2+ is a non-competitive inhibition. The inhibition constant value (Ki) is 26,84.
PENGARUH WALL BOUNCE INDIVIDU DAN BERPASANGAN TERHADAP KEMAMPUAN DAN SIKAP PASSING BAWAH BOLAVOLI
Authors: Sakip  , Gempur Santoso  , Sumardi  
Published: July 2020

Tujuan penelitian yaqng dilakukan di SMP Aswaja Legung adalah bertujuan untuk mendapatkan gambaran pengaruh metode pembelajaran passing bawah wall bounce individu dan kelompok berpasangan terhadap kemampuan dan sikap passing bawah bola voli pada siswa kelas VIII SMP Islam Aswaja Legung Barat Batang Batang Sumenep. Jenis penelitian adalah eksperimen, rancangan penelitian menggunakan pres tes post randomized control group desain, populasi dalam penelitian yang dilakukan adalah siswa SMP Aswaja Legung dan sampel penelitian yang merupakan siswa SMP adalah siswa kelas VIII 40 orang siswa. Jumlah sampel yang sudah diperoleh sebanyak 40 siswa putra dibagi menjadi dua kelompok, (1) kelompok pembelajaran passing secara individu, dan (2) kelompok eksperimen yang diberikan pembelajaran wall bounce. Tes yang digunakan adalah tes passing dan untuk analisis data dengan menggunakan uji multivariate yakni manova. Hasil penelitian menunjukan bahwa untuk memperoleh hasil yang diharapkan sesuai dengan rancangan mulai dari dari uji normalitas data yakni dengan taraf signifikan 0.05 hasil uji lebih besar dari alfa yakni 0,759, 0.988 dan 0.988 berdistribusi normal, uji homogenitas data dengan taraf signifikansi di atas 0.05 hasil uji lebih desar dari alfa, 0.800, 0.208, 0.232 sehingga dinyatakan data homogen, yang diteruskan pada hasil analisis multivariate hasil uji manova pada kolom di atas dengan menggunakan 4 model statistik meliputi Pillaiâ€™s, Wilks Lambda, q Hotellingq Tace dan Royâ€™s Largest Rootq didapatkan nilai signifikansi lebih kecil dari 0.05q (p<0.05) yang artinya H0 ditolak atau terdapat pengaruh yang sangat signifikan antara masing-masing variabel. Simpulan dari penelitian bahwa ada pengaruh untuk metode pembelajaran pasing bawah wall bounce individu dan kelompok berpasangan terhadap kemampuan dan sikap pasing bawah bolavoli pada siswa SMP. (2) Kelompok pasing dengan wall bounce memiliki kemampuan pasing lebih baik dan sikap pasing yang lebih baik, dibandingkan kelompok pasing berpasangan untuk kemampuan pasing dan sikap pasing.