bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal Evolution of Serum Concentrations of High‐Sensitivity Cardiac Troponin During 1 Year After Acute Coronary Syndrome Admission
Authors: van den Berg Victor J. , Oemrawsingh Rohit M. , Umans Victor A. W. M. , Kardys Isabella , Asselbergs Folkert W. , van der Harst Pim , Hoefer Imo E. , Kietselaer Bas , Lenderink Timo , Oude Ophuis Anton J. , van Schaik Ron H. , de Winter Robbert J. , Akkerhuis K. Martijn , Boersma Eric , Mulder Maarten , Schotborgh Carl , Ronner Eelko , Liem Anho , Haitsma David , Maas Arthur , Ilmer, Ben , Dijkgraaf Rene , Kie S. Hong , Wardeh Alexander J , Hermans Walther , Cramer Etienne , Doevendans Pieter A , Simoons Maarten L 
Published: December 2020

Background
Detailed insights in temporal evolution of high‐sensitivity cardiac troponin following acute coronary syndrome (ACS) are currently missing. We aimed to describe and compare the post‐ACS kinetics of high‐sensitivity cardiac troponin I (hs‐cTnI) and high‐sensitivity cardiac troponin T (hs‐cTnT), and to determine their intra‐ and interindividual variation in clinically stable patients.

Methods and Results

We determined hs‐cTnI (Abbott) and hs‐cTnT (Roche) in 1507 repeated blood samples, derived from 191 patients with ACS (median, 8/patient) who remained free from adverse cardiac events during 1‐year follow‐up. Post‐ACS kinetics were studied by linear mixed‐effect models. Using the samples collected in the 6‐ to 12‐month post‐ACS time frame, patients were then considered to have chronic coronary syndrome. We determined (differences between) the average hs‐cTnI and average hs‐cTnT concentration, and the intra‐ and interindividual variation for both biomarkers. Compared with hs‐cTnT, hs‐cTnI peaked higher (median 3506 ng/L versus 494 ng/L;
P
<0.001) and was quicker below the biomarker‐specific upper reference limit (16 versus 19 days;
P
<0.001). In the post–6‐month samples, hs‐cTnI and hs‐cTnT showed modest correlation (
r
spearman
=0.60), whereas the average hs‐cTnT concentration was 5 times more likely to be above the upper reference limit than hs‐cTnI. The intraindividual variations of hs‐cTnI and hs‐cTnT were 14.0% and 18.1%, while the interindividual variations were 94.1% and 75.9%.

Conclusions
Hs‐cTnI peaked higher after ACS and was quicker below the upper reference limit. In the post–6‐month samples, hs‐cTnI and hs‐cTnT were clearly not interchangeable, and average hs‐cTnT concentrations were much more often above the upper reference limit than hs‐cTnI. For both markers, the within‐patient variation fell largely below beween‐patient variation.

Registration

URL:
https://www.trialregister.nl
; unique identifiers: NTR1698 and NTR1106.
Refining Safe Contrast Limits for Preventing Acute Kidney Injury After Percutaneous Coronary Intervention
Authors: Yuan Neal , Latif Khalid , Botting Patrick G. , Elad Yaron , Bradley Steven M. , Nuckols Teryl K. , Cheng Susan , Ebinger Joseph E. 
Published: December 2020

Background
Contrast‐associated acute kidney injury (CA‐AKI) is associated with substantial morbidity and may be prevented by using less contrast during percutaneous coronary intervention (PCI). However, tools for determining safe contrast volumes are limited. We developed risk models to tailor safe contrast volume limits during PCI.

Methods and Results
Using data from all PCIs performed at 18 hospitals from January 2015 to March 2018, we developed logistic regression models for predicting CA‐AKI, including simpler models (“pragmatic full,” “pragmatic minimum”) using only predictors easily derivable from electronic health records. We prospectively validated these models using PCI data from April 2018 to December 2018 and compared them to preexisting safe contrast models using the area under the receiver operating characteristic curve (AUC). The model derivation data set included 20 579 PCIs with 2102 CA‐AKI cases. When applying models to the separate validation data set (5423 PCIs, 488 CA‐AKI cases), prior safe contrast limits (5*Weight/Creatinine, 2*CreatinineClearance) were poor measures of safety with accuracies of 53.7% and 56.6% in predicting CA‐AKI, respectively. The full, pragmatic full, and pragmatic minimum models performed significantly better (accuracy, 73.1%, 69.3%, 66.6%; AUC, 0.80, 0.76, 0.72 versus 0.59 for 5 * Weight/Creatinine, 0.61 for 2*CreatinineClearance). We found that applying safe contrast limits could meaningfully reduce CA‐AKI risk in one‐quarter of patients.

Conclusions
Compared with preexisting equations, new multivariate models for safe contrast limits were substantially more accurate in predicting CA‐AKI and could help determine which patients benefit most from limiting contrast during PCI. Using readily available electronic health record data, these models could be implemented into electronic health records to provide actionable information for improving PCI safety.
Deus est Homo
Authors: Bogdan Henrik 
Published: December 2020

Abstract
Despite the centrality of the concept of God in Christian theology and Western philosophy for over two millennia, little attention has been given the concept of God in twentieth-century occultism in general, and in the writings of Aleister Crowley (1875–1947) in particular. In this article it is argued that Crowley’s multifaceted and sometimes conflicting approaches to God, are dependent on five main factors: (1) his childhood experiences of Christianity in the form of the Plymouth Brethren, (2) the impact of Empirical Scepticism and Comparative Religion, (3) the emanationist concept of God that he encountered through his membership in the Hermetic Order of the Golden Dawn, (4) the revelation of The Book of the Law and the claim of being a Prophet, The Great Beast 666, of a New Age, and finally (5) solar-phallicism as expressed through the Ordo Templi Orientis. These apparently contradictory strands in Crowley’s biography and intellectual armoury are in fact interlinked, and it is by studying them together that it is possible to identify the concept of God in Crowley’s magical writings.
Things That Don’t Talk Much and Things That Feel
Authors: Neswald Elizabeth 
Published: December 2020

Abstract
This essay explores whether and how objects that seem pedestrian and anonymous can be made fruitful for material culture study. Using the example of late 20th-century blood glucose monitors for diabetes, it assesses the potential and limitations of common approaches to the study of material objects, when the object itself is unremarkable. It then turns to object- and experiment-oriented work in the history of science and seeks to integrate the concepts of tacit and embodied knowledge to formulate an approach to medical objects based on bodies and practices. Comparisons between monitors show how changes in their material configuration affected these practices and, by extension, changed the relationship between user and object. Finally, it looks to studies on the objects and practices of medicine and healthcare at the intersection of bodies and emotions and asks what insights they can provide for the study of modern medical devises.
Material Traces of Disability
Authors: Virdi Jaipreet 
Published: December 2020

Abstract
This paper examines the lived experiences of Canadian machinist and double-amputee Andrew A. Gawley (1895–1961), whose prosthetic “steel hands” rose him to fame during the mid-twentieth century, to analyze how disability objects can illuminate complex tensions of unruliness to represent a fraught epistemological materiality. Drawing on Williamson and Guffey’s “design model of disability,” I argue that Gawley’s prostheses are physical and tangible representations of his need to achieve functional normalcy. His self-reliance and identity was not only premised on ability, but dependent upon the complex unruliness ascribed within the prostheses, such that the sensationalized freakery of the “steel hands” become as crucial to Gawley’s identity as his performances of normative masculinity.
Classifications of Knowledge in Classical Islamic Mysticism: from Eastern Sufi Sources to the Writings of Muḥyī l-Dīn Ibn al-ʿArabī
Authors: Ebstein Michael 
Published: December 2020

Abstract
The following article aims at analyzing various classifications of knowledge that are found in the literature of classical Islamic mysticism. The discussion focuses on two main corpora: Sufi writings, composed in the central and eastern parts of the Islamic world, and works by the Andalusī mystics or theosophists Ibn Masarra (d. 319/931), Ibn Barraǧān (d. 536/1141), Ibn Qasī (d. 546/1151), and Muḥyī l-Dīn Ibn al-ʿArabī (d. 638/1240). The article examines the discrepancies between the Eastern-Sufi and Andalusī taxonomies of knowledge, in an attempt to highlight the typological differences between these two mystical traditions of classical Sunnī Islam.
Genesis and Decay of Mesoscale Baroclinic Eddies in the Seasonally Ice-Covered Interior Arctic Ocean
Authors: Meneghello Gianluca , Marshall John , Lique Camille , Isachsen Pål Erik , Doddridge Edward , Campin Jean-Michel , Regan Heather , Talandier Claude 
Published: December 2020

AbstractObservations of ocean currents in the Arctic interior show a curious, and hitherto unexplained, vertical and temporal distribution of mesoscale activity. A marked seasonal cycle is found close to the surface: strong eddy activity during summer, observed from both satellites and moorings, is followed by very quiet winters. In contrast, subsurface eddies persist all year long within the deeper halocline and below. Informed by baroclinic instability analysis, we explore the origin and evolution of mesoscale eddies in the seasonally ice-covered interior Arctic Ocean. We find that the surface seasonal cycle is controlled by friction with sea ice, dissipating existing eddies and preventing the growth of new ones. In contrast, subsurface eddies, enabled by interior potential vorticity gradients and shielded by a strong stratification at a depth of approximately 50 m, can grow independently of the presence of sea ice. A high-resolution pan-Arctic ocean model confirms that the interior Arctic basin is baroclinically unstable all year long at depth. We address possible implications for the transport of water masses between the margins and the interior of the Arctic basin, and for climate models’ ability to capture the fundamental difference in mesoscale activity between ice-covered and ice-free regions.
Cultural competency training for psychiatry residents and mental health professionals: A systematic review
Authors: Venkataramu Vyjayanthi N , Vajawat Bhavika , Raghuraman Bharathram Sathur , Chaturvedi SK 
Published: December 2020

Introduction: Cultural competence is a prerequisite skill for a psychiatrist. There is a dearth of information on the methods used for training of cultural competence and their outcomes. This study aims to explore and determine the existing methods used for cultural competency training (CCT) for psychiatry residents and how useful these training methods are. Method: A systematic review methodology based on PRISMA guidelines was adopted for this study. The literature search reviewed databases of PubMed and MesH, using keywords ‘psychiatry resident’, ‘psychiatry’, ‘psychiatrist’, ‘mental health’, and ‘mental health professional’. In the end,14 articles qualified for the detailed review. The level of evidence and quality of the studies were evaluated and recorded. Results: The methods of cultural competence training identified were grouped as, active/passive/mixed; group training/individual training. These included documentaries or non-feature films based teaching, secondary consultation and cross consultation models, case vignette discussions, Objective Structured Clinical Examination (OSCE), behavioral simulation, video demonstration, cultural discussion in rounds, and traditional clinical teaching. The studies covered participants from different cultural backgrounds, mainly urban and predominantly university/institution based. Conclusion: There is limited literature in the area to conclude one method to be better than the other with respect to CCT in psychiatry residents. However, this review identified a variety of training methods, which can be used and pave way for research on their effectiveness. Training and evaluation of psychiatry residents in the area of cultural competence should be done routinely during their training to enable them to practice in the multi ethic societies.
Drugs, Violence, and Capitalism: The Expansion of Opioid Use in the Americas
Authors: Pereira Paulo José dos Reis 
Published: December 2020

In the past two decades, the United States has experienced a rapid rise in the use of opioids by its population, a context that has come to be assessed by the U.S. government as a threat to national and international security that requires emergency measures. The strategies of the U.S. government and transnational pharmaceutical corporations for resolving the insecurity generated by capitalist accumulation constitute what a certain literature calls “pacification.” In addition, these corporations export to the “foreign” the contradictions inherent in the opioid control policy that underlies the capitalist logic of drugs. Thus Latin American populations have been instrumentalized in the “solution” of this crisis either as a focus of violence by the state or as a focus of consumption by the market. Nas últimas duas décadas, os Estados Unidos vivenciaram uma rápida ascensão do uso de opioides pela sua população, contexto que passou a ser avaliado pelo governo estadunidense como uma ameaça à segurança nacional e internacional que demanda medidas emergenciais. As estratégias do Estado estadunidense e das corporações farmacêuticas transnacionais para solucionar a insegurança gerada pela acumulação capitalista configuram o que certa literatura chama “pacificação” Ademais, elas exportam para o “estrangeiro” as contradições próprias da política de controle de opioides que fundamenta a lógica capitalista das drogas. Assim, populações latino-americanas têm sido instrumentalizadas para a “solução” dessa crise, seja como foco da violência pelo Estado, seja como foco do consumo pelo mercado.
Socio-territorial Disputes and Violence on Fracking Land in Vaca Muerta, Argentina
Authors: Hadad María Gisela , Palmisano Tomás , Wahren Juan 
Published: December 2020

With the discovery of unconventional hydrocarbon deposits and the consequent expansion of the commodity frontiers in the past decade, a series of territorial disputes over the geological formation called Vaca Muerta has arisen in the province of Neuquén, Argentina, between oil companies, Mapuche indigenous communities, pastoralists, and the state. A general panorama of territorial conflict, state and parastate violence, tension, and negotiation among various actors in conflict in the department of Añelo suggests that violence in the territory is complex and multidimensional, since it supposes the superposition of its direct, structural, ecological, epistemic, and mercantilist forms. En la última década, con el descubrimiento de yacimientos de hidrocarburos no convencionales y la consiguiente ampliación de la frontera mercantil, se han generado en la provincia de Neuquén, Argentina, una serie de disputas territoriales en torno a la formación geológica denominada Vaca Muerta entre empresas petroleras, comunidades indígenas mapuche, crianceros y diferentes niveles del Estado. Un panorama general de la conflictividad territorial, violencias estatales y para-estatales, procesos de tensión y negociación entre los diferentes actores en pugna del departamento de Añelo sugiere que la violencia en el territorio es de carácter complejo y multidimensional pues supone la superposición de su forma directa, estructural, ecológica, epistémica y mercantil.
The Value of Handwritten Notes: A Failure to Find State-Dependent Effects When Using a Laptop to Take Notes and Complete a Quiz
Authors: Crumb Roni M. , Hildebrandt Ryan , Sutton Tina M. 
Published: December 2020

Background: Many students use laptops in the classroom to take notes; however, even when laptops are used for the sole purpose of taking notes they can negatively impact academic performance. Objective: The current study examined state-dependent effects, and the potential for a match in note taking and quiz taking methods to improve quiz performance. Method: Participants were placed into a congruent (take notes by hand and complete the quiz by hand or take notes using a laptop and complete an online quiz) or an incongruent condition (take notes by hand and take an online quiz or take notes using a laptop and complete the quiz by hand). Results: The results revealed that participants who took notes by hand performed better on the quiz overall, and better on conceptual questions, then students who took notes using a laptop. We failed to find evidence for state-dependent effects. Conclusions: The current study suggests that taking notes by hand may improve how students encode material, and result in higher quality external storage used by students when studying for quizzes. Teaching Implications: Reinforcing the notion that taking notes by hand may benefit quiz performance for lecture-style information and could improve student performance in class.
Gallincin ameliorates colitis-associated inflammation and barrier function in mice based on network pharmacology prediction
Authors: Cui De-jun , Yang Xiao-lan , Okuda Shujiro , Ling Yi-wei , Zhang Zhu-xue , Liu Qi , Yuan Wen-qiang , Yan Fang 
Published: December 2020

Objective To explore potential mechanisms and effects of gallincin on a mouse model of colitis induced by dextran sulfate sodium (DSS). Methods Network pharmacology analysis was used to predict the molecular mechanism of action of gallincin for treatment of colitis. Gallincin was administered orally to mice with DSS-induced colitis. Expression of tumor necrosis factor α (TNF-α), D-lactate, and interleukin-1β (IL-1β) and myeloperoxidase activity were assessed with real-time quantitative PCR and an enzyme-linked immunoassay, respectively. Expression of occludin, zonula occludens 1 (ZO-1), and phosphorylated extracellular signal-regulated protein kinase1/2 (p-ERK1/2) was analyzed with immunohistochemical staining and/or western blot assays. Results Using a network pharmacology approach, 12 mapping targets between gallincin and colitis were obtained, including ERK/mitogen-activated protein kinase. Further investigations in an experimental colitis mouse model showed that gallincin significantly ameliorated experimental colitis, reduced D-lactate levels, and remarkably increased occludin and ZO-1 expression, possibly in part by decreasing IL-1β, TNF-α, and p-ERK1/2 levels and inhibiting leukocyte penetration. Conclusions Gallincin regulated colonic barrier function and reduced colitis-associated inflammation, suggesting it is a promising drug for the treatment of ulcerative colitis.
Effects of tacrolimus on autophagy protein LC3 in puromycin-damaged mouse podocytes
Authors: Yang Xiao-qing , Yu Sheng-you , Yu Li , Ge Lin , Zhang Yao , Hao Zhi-hong , Liu Guo-sheng 
Published: December 2020

Objective To investigate the mechanism through which tacrolimus, often used to treat refractory nephropathy, protects against puromycin-induced podocyte injury. Methods An in vitro model of puromycin-induced podocyte injury was established by dividing podocytes into three groups: controls, puromycin only (PAN group), and puromycin plus tacrolimus (FK506 group). Podocyte morphology, number, apoptosis rate and microtubule associated protein 1 light chain 3 alpha ( LC3) expression were compared. Results Puromycin caused podocyte cell body shrinkage and loose intercellular connections, but podocyte morphology in the FK506 group was similar to controls. The apoptosis rate was lower in the FK506 group versus PAN group. The low level of LC3 mRNA observed in untreated podocytes was decreased by puromycin treatment; however, levels of LC3 mRNA were higher in the FK506 group versus PAN group. Although LC3-I and LC3-II protein levels were decreased by puromycin, levels in the FK506 group were higher than the PAN group. Fewer podocyte autophagosomes were observed in the control and FK506 groups versus the PAN group. Cytoplasmic LC3-related fluorescence intensity was stronger in control and FK506 podocytes versus the PAN group. Conclusions Tacrolimus inhibited puromycin-induced mouse podocyte damage by regulating LC3 expression and enhancing autophagy.
Factors affecting the success of fallopian tube recanalization in treatment of tubal obstructive infertility
Authors: Shen Huawei , Cai Mingjin , Chen Tingwei , Zheng Duzhou , Huang Shikuan , Zhou Mimi , He Wanling , Li Yongsen , Tan Qianyan 
Published: December 2020

Objective To examine potential risk factors associated with the success rate following fallopian tube recanalization (FTR) in infertile women with obstruction of the proximal fallopian tube. Methods We retrospectively studied patients who underwent FTR for tubal obstructive infertility between January 2016 and December 2018 at the Third Affiliated Hospital of Guangzhou Medical University. FTR was performed using a catheter and guidewire system to clear tubal obstruction. Predictive factors potentially associated with the success rate were assessed by logistic regression. Results A total of 762 patients were included. Multivariable analysis showed that age (odds ratio [OR] = 2.38, 95% confidence interval [CI]: 1.24–4.58), infertility type (OR = 2.82, 95% CI: 1.36–6.21), history of ectopic pregnancy (OR = 7.87, 95% CI: 4.05–15.81), history of abdominal surgery (OR = 4.30, 95% CI: 2.22–8.60), history of artificial abortion curettage (OR = 4.08, 95% CI: 2.12–8.03), and duration of infertility (OR = 2.03, 95% CI: 1.06–3.85) were independently associated with postoperative tubal patency. Conclusions Our findings suggest that risk factors, such as age ≥35 years, secondary infertility, duration of infertility ≥5 years, and histories of ectopic pregnancy, abdominal surgery, and artificial abortion curettage, affect the success rate of FTR. These factors may also predict surgical success in treating tubal obstructive infertility.
Cognitive, Motor, and Language Development of Preschool Children With Craniofacial Microsomia
Authors: Collett Brent R. , Wallace Erin R. , Kapp-Simon Kathleen A. , Johns Alexis L. , Drake Amelia F. , Heike Carrie L. , Kinter Sara , Luquetti Daniela V. , Magee Leanne , Norton Susan , Sie Kathleen , Speltz Matthew L. 
Published: December 2020

Objective: To examine neurodevelopment in preschool-aged children with craniofacial microsomia (CFM) relative to unaffected peers. Design: Multisite, longitudinal cohort study. Setting: Tertiary care centers in the United States. Participants: We included 92 children with CFM (“cases”) through craniofacial centers and clinics. Seventy-six children without CFM (controls) were included from pediatric practices and community advertisements. This study reports on outcomes assessed when participants were an average age of 38.4 months (SD = 1.9). Main outcome measures: We assessed cognitive and motor skills using the Bayley Scales of Infant and Toddler Development, third edition (Bayley-III), and language function using subtests from the Clinical Evaluation of Language Fundamentals—Preschool, second edition (CELF-P2). Results: Case–control differences were negligible for Bayley-III cognitive (effect sizes [ES] = −0.06, P = .72) and motor outcomes (ES = −0.19, P = .25). Cases scored lower than controls on most scales of the CELF-P2 (ES = −0.58 to −0.20, P = .01 to .26). Frequency counts for “developmental delay” (ie, one or more scores > 1 SD below the normative mean) were higher for cases (39%) than controls (15%); however, the adjusted odds ratio = 1.73 ( P = 0.21) was not significant. Case–control differences were most evident in children with microtia or other combinations of CFM-related facial features. Conclusions: Cognitive and motor scores were similar for preschool-aged children with and without CFM. However, children with CFM scored lower than controls on language measures. We recommend early monitoring of language to identify preschoolers with CFM who could benefit from intervention.