bluuebunny/crossref_metadata_2025_split huggingface dataset:
Problems with social acceptance and social victimization predict substance use among U.S. Reserve/Guard soldiers
Authors: Hoopsick Rachel A. , Vest Bonnie M. , Homish D. Lynn , Homish Gregory G. 
Published: January 2020

AbstractThe effects of negative social interactions/experiences on substance use have largely been studied in civilian populations, but less is known about United States Army Reserve/National Guard (USAR/NG) soldiers—a high‐risk group. We examined the associations between problems with social acceptance, social victimization, and substance use among USAR/NG soldiers, and examined potential differences by deployment history. The sample consisted of soldiers who completed baseline and 1‐year follow‐up assessments (N = 445) of Operation: SAFETY, an ongoing study of USAR/NG soldiers. We examined the effects of baseline problems with social acceptance/social victimization on nonmedical use of prescription drugs (NMUPD), illicit drug use, frequent heavy drinking (FHD), and alcohol problems at follow‐up. Significant effects were small in magnitude but consistent in direction. Greater problems with social acceptance were associated with higher odds of NMUPD and illicit drug use. Greater social victimization was associated with higher odds of NMUPD and illicit drug use. There were no differences by deployment history. Problems with social acceptance/social victimization were not associated with FHD or alcohol problems. Problems with social acceptance/social victimization may contribute to drug use among USAR/NG soldiers. Intervention programs should address social issues, regardless of deployment history.
Plasmonic Nanoassemblies: Tentacles Beat Satellites for Boosting Broadband NIR Plasmon Coupling Providing a Novel Candidate for SERS and Photothermal Therapy
Authors: Dey Priyanka , Tabish Tanveer A. , Mosca Sara , Palombo Francesca , Matousek Pavel , Stone Nicholas 
Published: January 2020

AbstractOptical theranostic applications demand near‐infrared (NIR) localized surface plasmon resonance (LSPR) and maximized electric field at nanosurfaces and nanojunctions, aiding diagnosis via Raman or optoacoustic imaging, and photothermal‐based therapies. To this end, multiple permutations and combinations of plasmonic nanostructures and molecular “glues” or linkers are employed to obtain nanoassemblies, such as nanobranches and core–satellite morphologies. An advanced nanoassembly morphology comprising multiple linear tentacles anchored onto a spherical core is reported here. Importantly, this core‐multi‐tentacle‐nanoassembly (CMT) benefits from numerous plasmonic interactions between multiple 5 nm gold nanoparticles (NPs) forming each tentacle as well as tentacle to core (15 nm) coupling. This results in an intense LSPR across the “biological optical window” of 650−1100 nm. It is shown that the combined interactions are responsible for the broadband LSPR and the intense electric field, otherwise not achievable with core–satellite morphologies. Further the sub 80 nm CMTs boosted NIR‐surface‐enhanced Raman scattering (SERS), with detection of SERS labels at 47 × 10‐9 m, as well as lower toxicity to noncancerous cell lines (human fibroblast Wi38) than observed for cancerous cell lines (human breast cancer MCF7), presents itself as an attractive candidate for use as biomedical theranostics agents.
Endochondral ossification and the evolution of limb proportions
Authors: Rolian Campbell 
Published: January 2020

AbstractMammals have remarkably diverse limb proportions hypothesized to have evolved adaptively in the context of locomotion and other behaviors. Mechanistically, evolutionary diversity in limb proportions is the result of differential limb bone growth. Longitudinal limb bone growth is driven by the process of endochondral ossification, under the control of the growth plates. In growth plates, chondrocytes undergo a tightly orchestrated life cycle of proliferation, matrix production, hypertrophy, and cell death/transdifferentiation. This life cycle is highly conserved, both among the long bones of an individual, and among homologous bones of distantly related taxa, leading to a finite number of complementary cell mechanisms that can generate heritable phenotype variation in limb bone size and shape. The most important of these mechanisms are chondrocyte population size in chondrogenesis and in individual growth plates, proliferation rates, and hypertrophic chondrocyte size. Comparative evidence in mammals and birds suggests the existence of developmental biases that favor evolutionary changes in some of these cellular mechanisms over others in driving limb allometry. Specifically, chondrocyte population size may evolve more readily in response to selection than hypertrophic chondrocyte size, and extreme hypertrophy may be a rarer evolutionary phenomenon associated with highly specialized modes of locomotion in mammals (e.g., powered flight, ricochetal bipedal hopping). Physical and physiological constraints at multiple levels of biological organization may also have influenced the cell developmental mechanisms that have evolved to produce the highly diverse limb proportions in extant mammals.This article is categorized under:
Establishment of Spatial and Temporal Patterns > Regulation of Size, Proportion, and Timing
Comparative Development and Evolution > Regulation of Organ Diversity
Comparative Development and Evolution > Organ System Comparisons Between Species
Protein‐based nanoplatforms for tumor imaging and therapy
Authors: Liang Kaicheng , Chen Hangrong 
Published: January 2020

AbstractCancer is one of the leading causes of death all over the world. The development of nanoplatform provides a promising strategy for the diagnosis and treatment of cancer. As the foundation of the nanoplatform, the composition of nanocarrier decides the basic properties. Protein exists in all kinds of life and participates in any life activities, having great potentials to serve as a nanocarrier because of its excellent biocompatibility, abundance of functional groups, and inherent biological activity. As a result, protein‐based nanoplatforms have evoked extensive interests for tumor imaging and therapy. This review presents the latest progresses on the advancement of protein‐based nanoplatforms, introducing the most common protein nanocarriers (such as human/bovine serum albumin, ferritin, human transferrin) thoroughly including their physiochemical properties and specific applications. Also, other kinds of protein are briefly involved. Finally, the prospects and challenges of the development of protein‐based nanoplatforms are summarized.This article is categorized under:Biology‐Inspired Nanomaterials > Protein and Virus‐Based StructuresTherapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
Suitability of analytical methods to determine tebuconazole, propiconazole and permethrin in aged wood samples
Authors: Schoknecht Ute , Drescher Petra , Fischer Martin , Fürhapper Christina , Gunschera Jan , Hill Rainer , Melcher Eckhard , Wegner Robby , Wilken Ursula , Wittenzellner Joachim 
Published: January 2020

AbstractThe suitability of common analytical methods for the determination of active substances from wood preservatives in aged wood samples was investigated during an interlaboratory study. Permethrin, propiconazole and tebuconazole were quantified in 1.5 and 8 year-old wood samples by gas chromatography and liquid chromatography. Generally, the applied methods yielded reliable results for these samples. However, wood components can coelute with propiconazole and tebuconazole during liquid chromatography. Optimization of separation might be required if UV detection is applied.
Effect of supercritical CO2 treatment and kiln drying on collapse in Eucalyptus nitens wood
Authors: Dawson Bernard S. W. , Pearson Hamish , Kimberley Mark O. , Davy Bruce , Dickson Alan R. 
Published: January 2020

AbstractCollapse-prone timbers such as species of Eucalyptus are poorly utilised due to low conversion rates that necessitate long pre-drying times. A supercritical CO2 lumen water expulsion pre-treatment prior to kiln drying is proposed to bypass lengthy pre-drying. After drying (air, kiln or oven drying), shrinkage, collapse, washboard depression and checking of Eucalyptus nitens were determined using image analysis of 0.8 mm thick wafers and 5 mm thick biscuits. Lumen water expulsion-kiln drying reduced collapse by 75% and washboard depression by 71%, compared to drying from green. As water is removed from the water conductive tissue (vessels, rays, and fibre-tracheids) by lumen water expulsion, the water column is broken throughout the specimen, thereby disrupting the development of meniscus-induced water tension as subsequent drying occurs. Remaining water is proposed to reside in the non-water-conductive fibre tissue. If the process can be applied on large scale to Eucalyptus nitens, there is the opportunity for higher conversion rates to increase the commercial viability of solid wood products.
MicroRNA-181a regulates IFN-γ expression in effector CD8+ T cell differentiation
Authors: Amado Tiago , Amorim Ana , Enguita Francisco J. , Romero Paula V. , Inácio Daniel , de Miranda Marta Pires , Winter Samantha J. , Simas J. Pedro , Krueger Andreas , Schmolka Nina , Silva-Santos Bruno , Gomes Anita Q. 
Published: January 2020

AbstractCD8+ T cells are key players in immunity against intracellular infections and tumors. The main cytokine associated with these protective responses is interferon-γ (IFN-γ), whose production is known to be regulated at the transcriptional level during CD8+ T cell differentiation. Here we found that microRNAs constitute a posttranscriptional brake to IFN-γ expression by CD8+ T cells, since the genetic interference with the Dicer processing machinery resulted in the overproduction of IFN-γ by both thymic and peripheral CD8+ T cells. Using a gene reporter mouse for IFN-γ locus activity, we compared the microRNA repertoires associated with the presence or absence of IFN-γ expression. This allowed us to identify a set of candidates, including miR-181a and miR-451, which were functionally tested in overexpression experiments using synthetic mimics in peripheral CD8+ T cell cultures. We found that miR-181a limits IFN-γ production by suppressing the expression of the transcription factor Id2, which in turn promotes the Ifng expression program. Importantly, upon MuHV-4 challenge, miR-181a-deficient mice showed a more vigorous IFN-γ+ CD8+ T cell response and were able to control viral infection significantly more efficiently than control mice. These data collectively establish a novel role for miR-181a in regulating IFN-γ–mediated effector CD8+ T cell responses in vitro and in vivo.
Relaxation of selective constraints shapes variation of toll-like receptors in a colonial waterbird, the black-headed gull
Authors: Podlaszczuk Patrycja , Indykiewicz Piotr , Markowski Janusz , Minias Piotr 
Published: January 2020

AbstractNonspecific innate immune response is activated by toll-like receptors (TLRs), which recognize conserved molecular motifs characteristic for a broad spectrum of pathogens. In this study, we examined nucleotide substitution patterns and allelic diversity at five TLR genes in a wild nonpasserine bird, the black-headed gullChroicocephalus ridibundus. We hypothesized that balancing selection can maintain high allelic diversity of TLR genes in the black-headed gull because of its ecological characteristics, coloniality, and migratoriness, which are associated with increased exposure and transmission of pathogens. Although we found moderately high levels of sequence polymorphism (8–49 haplotypes retrieved per locus within a sample of 60 individuals), most of these haplotypes were recorded at low frequencies within our study population. At the same time, we found no convincing evidence for the role of balancing selection in the maintenance of this variation (Tajima’s D < 0.5), and sites with a significant excess of nonsynonymous mutations (dN/dS > 1) were recorded only at two loci (TLR5 and TLR7). This pattern is consistent with relaxation of selective constraints, where most mutations are slightly deleterious and usually removed by purifying selection. No differences in the diversity and nucleotide substitution rates were found between endosomal loci responsible for viral RNA sensing and loci responsible for the recognition of extracellular pathogens. Our study provides the first information on evolutionary mechanisms shaping polymorphism of TLRs in a species from Lari suborder (gulls and allies) and suggests that TLR genes may be poorly responsive to ecological and life-history characteristics of hosts.
Best match graphs and reconciliation of gene trees with species trees
Authors: Geiß Manuela , Laffitte Marcos E. González , Sánchez Alitzel López , Valdivia Dulce I. , Hellmuth Marc , Rosales Maribel Hernández , Stadler Peter F. 
Published: January 2020

AbstractA wide variety of problems in computational biology, most notably the assessment of orthology, are solved with the help of reciprocal best matches. Using an evolutionary definition of best matches that captures the intuition behind the concept we clarify rigorously the relationships between reciprocal best matches, orthology, and evolutionary events under the assumption of duplication/loss scenarios. We show that the orthology graph is a subgraph of the reciprocal best match graph (RBMG). We furthermore give conditions under which an RBMG that is a cograph identifies the correct orthlogy relation. Using computer simulations we find that most false positive orthology assignments can be identified as so-called good quartets—and thus corrected—in the absence of horizontal transfer. Horizontal transfer, however, may introduce also false-negative orthology assignments.
A meta-analysis of total knee arthroplasty following high tibial osteotomy versus primary total knee arthroplasty
Authors: Sun Xuedong , Wang Jun , Su Zheng 
Published: January 2020

AbstractBackgroundThis study was performed to compare the clinical and radiographic outcomes of total knee arthroplasty (TKA) following high tibial osteotomy (HTO) versus primary TKA.MethodsRelevant trials were identified via a search of Ovid, PubMed and the Cochrane Central Register of Controlled Trials from inception to 10 January 2019. A meta-analysis was performed to compare postoperative outcomes between revising HTO to TKA (RHTO) and primary TKA (PTKA) with respect to Knee Society Score (KSS), 10-year survival rate, operative time, flexion and extension angle, infection rate and radiographic results.ResultsSixteen of 340 studies involving 103,552 adult patients (RHTO group,n = 3955; PTKA group,n = 99,597) were eligible for inclusion in the meta-analysis. Compared with primary TKA, revising HTO to TKA required longer operative time and had a higher infection rate (P < 0.05). The PTKA group had better flexion angle than the RHTO group (P < 0.05). There were no significant differences between the two groups in the KSS, extension angle, radiographic results and 10-year survival rate (P > 0.05).ConclusionPatients who undergo conversion of HTO to TKA have similar 10-year survival rate, KSS, extension angle and radiographic results as patients who undergo primary TKA. However, conversion of HTO to TKA required longer operative time and had a higher infection rate than performing primary TKA. Moreover, conversion of HTO to TKA is associated with poorer flexion angle than primary TKA.
Braided peridotite sills and metasomatism in the Rum Layered Suite, Scotland
Authors: Hepworth Luke N. , Kaufmann Felix E. D. , Hecht Lutz , Gertisser Ralf , O’Driscoll Brian 
Published: January 2020

AbstractThe Rum Eastern Layered Intrusion (ELI; Scotland) is an open-system layered intrusion constructed of 16 macro-rhythmic units. Each of the macro-rhythmic units consists of a peridotite base and a troctolite (± gabbro) top, previously attributed to the fractional crystallisation of a single magma batch. This classic paradigm has been challenged, however, with evidence presented for the emplacement of peridotite sills in Units 9, 10, and 14, such as cross-cutting relationships, upward-oriented apophyses, and lateral discontinuities. To test whether the other major peridotites within the ELI represent sills, we have carried out new field, petrographic, and mineral chemical analyses of the peridotites in Units 7, 8 and 9. The peridotites display large- and small-scale cross-cutting relationships with the overlying troctolite, indicative of an intrusive relationship. The peridotites also show large-scale coalescence and lateral spatial discontinuities such that the ELI unit divisions become arbitrary. Harrisite layers and Cr-spinel seams found throughout Units 7, 8, and 9 suggest the peridotites were constructed incrementally via repeated injections of picritic magma. Our observations allow for distinct subtypes of peridotite to be defined, separated by intrusive contacts, allowing for their relative chronology to be determined. Older, poikilitic peridotite, rich in clinopyroxene, is truncated by younger, well-layered peridotite, containing abundant harrisite layers. In addition to the new peridotite subtypes defined in this study, we find strong evidence for laterally oriented metasomatism within clinopyroxene-rich wehrlites at the top of the Unit 8 peridotite. The wehrlites and surrounding peridotites record a complex series of metasomatic reactions that transformed thin picrite sills into clinopyroxene-rich wehrlites without any evidence for the sort of vertical melt movement typically posited in layered intrusions. The observations presented in this study from the ELI cannot be reconciled with the classic magma chamber paradigm and are better explained by the emplacement of composite sills into pre-existing feldspathic cumulate (gabbro or troctolite). The evidence for sill emplacement presented here suggests that the layered complex was constructed by a combination of sill emplacement and metasomatism, forming many of the unusual (often clinopyroxene-rich) lithologies that surround the sills. The broad-scale formation of the layered peridotites via incremental sill emplacement, suggested by the occurrence of upward-oriented apophyses, coalescence, and lateral discontinuity, could be applied to much larger ultramafic intrusions, which might have formed by similar mechanisms.
Acute cytotoxic effects of silica microparticles used for coating of plastic blood-collection tubes on human periosteal cells
Authors: Masuki Hideo , Isobe Kazushige , Kawabata Hideo , Tsujino Tetsuhiro , Yamaguchi Sadahiro , Watanabe Taisuke , Sato Atsushi , Aizawa Hachidai , Mourão Carlos Fernando , Kawase Tomoyuki 
Published: January 2020

AbstractBecause of its simple operation, platelet-rich fibrin (PRF) is becoming more popular than the original form, platelet-rich plasma (PRP), in regenerative dentistry. PRF preparation requires plain glass blood-collection tubes, but not either anticoagulants or coagulation factors. However, such glass tubes designed for laboratory testing are no longer commercially available. Although several glass tubes specifically designed for PRF preparation are available, many clinicians prefer to obtain stably supplied substitutes, such as silica-coated plastic tubes produced by major medical device companies. The quality of PRF prepared by silica-coated tubes has not been assessed and we previously reported significant contamination of silica microparticles in the resulting PRF matrix and alerted clinicians against the use for PRF preparation. To further assess the biosafety of the silica microparticles, we presently examined their effects on human normal periosteal cells derived from alveolar bone. The periosteal cells were obtained from explant cultures of small periosteal tissues obtained from healthy donors. Silica microparticles were obtained from silica-coated tubes and added to cell cultures. Cellular responses were monitored using a tetrazolium assay, phase-contract inverted microscopy, an immunofluorescence method, and scanning electron microscopy. Silica microparticles adsorbed onto the cell surface with seemingly high affinity and induced apoptosis, resulting in significant reduction of cell proliferation and viability. These findings suggest that silica microparticles contained in plastic tubes for the purpose of blood coagulation are hazardous for various cell types around sites where silica-contaminated PRF matrices are implanted.
Libra — A Differentiated View on Facebook’s Virtual Currency Project
Authors: Brühl Volker 
Published: January 2020

AbstractLibra — a global virtual currency project initiated by Facebook — has been the subject of many controversial discussions since its announcement in June 2019. This paper provides a differentiated view on Libra, recognising that different development scenarios of Libra are conceivable. Libra could serve purely as an alternative payment system in combination with a dedicated payment token, the Libra coin. Alternatively, the Libra project could develop into a broader financial infrastructure for advanced financial services such as savings and loan products operating on the Libra Blockchain. Based on a comparison of the Libra architecture with other cryptocurrencies, the opportunities and challenges for the development of the respective Libra ecosystems are investigated from a commercial, regulatory and monetary policy perspective.
Enhanced index tracking with CVaR-based ratio measures
Authors: Guastaroba Gianfranco , Mansini Renata , Ogryczak Wlodzimierz , Speranza M. Grazia 
Published: January 2020

AbstractThe enhanced index tracking problem (EITP) calls for the determination of an optimal portfolio of assets with the bi-objective of maximizing the excess return of the portfolio above a benchmark and minimizing the tracking error. The EITP is capturing a growing attention among academics, both for its practical relevance and for the scientific challenges that its study, as a multi-objective problem, poses. Several optimization models have been proposed in the literature, where the tracking error is measured in terms of standard deviation or in linear form using, for instance, the mean absolute deviation. More recently, reward-risk optimization measures, like the Omega ratio, have been adopted for the EITP. On the other side, shortfall or quantile risk measures have nowadays gained an established popularity in a variety of financial applications. In this paper, we propose a class of bi-criteria optimization models for the EITP, where risk is measured using the weighted multiple conditional value-at-risk (WCVaR). The WCVaR is defined as a weighted combination of multiple CVaR measures, and thus allows a more detailed risk aversion modeling compared to the use of a single CVaR measure. The application of the WCVaR to the EITP is analyzed, both theoretically and empirically. Through extensive computational experiments, the performance of the optimal portfolios selected by means of the proposed optimization models is compared, both in-sample and, more importantly, out-of-sample, to the one of the portfolios obtained using another recent optimization model taken from the literature.