bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of pharmacogenetics in oncology
Authors: Miteva-Marcheva Nelly N. , Ivanov Hristo Y. , Dimitrov Dimitar K. , Stoyanova Vili K. 
Published: August 2020

AbstractThe term “pharmacogenetics” is used to describe the study of variability in drug response due to heredity. It is associated with “gene – drug interactions”. Later on, the term “pharmacogenomics” has been introduced and it comprises all genes in the genome that can define drug response. The application of pharmacogenetics in oncology is of a great significance because of the narrow therapeutic index of chemotherapeutic drugs and the risk for life-threatening adverse effects. Many cancer genomics studies have been focused on the acquired, somatic mutations; however, increasing evidence shows that inherited germline genetic variations play a key role in cancer risk and treatment outcome. The aim of this review is to summarize the state of pharmacogenomics in oncology, focusing only on germline mutations. Genetic polymorphisms can be found in the genes that code for the metabolic enzymes and cellular targets for most of the chemotherapy drugs. Nevertheless, predicting treatment outcome is still not possible for the majority of regimens. In this review, we discuss the most comprehensively studied drug-gene pairs – present knowledge and current limitations. However, further studies in larger groups of cancer patients are necessary to be conducted with precise validation of pharmacogenetic biomarkers before these markers could be routinely applied in clinical diagnosis and treatment.
Compliance with the north American Society of Pacing and Electrophysiology guidelines on amiodarone monitoring in Riyadh, Saudi Arabia: a retrospective charts review study
Authors: Albassam Bander Ahmed , Almutairi Nouf Mohammed , Aldosari Sarah Fahad , Almodaimegh Hind Saleh 
Published: August 2020

Abstract
Background
Amiodarone is known for its efficacy as an antiarrhythmic agent; however, its extensive side-effect profile requires careful selection of patients and frequent monitoring. The purpose of this study was to evaluate the performance of the baseline tests before initiating amiodarone therapy and the on-going monitoring based on the North American Society of Pacing and Electrophysiology guidelines recommendations.

Methods
A retrospective descriptive charts review study included all patients who are 18 years of age and older and were started on oral amiodarone with a primary diagnosis of any type of cardiac arrhythmia from January 2016 to December 2018 in King Abdualziz Medical City, Riyadh, Saudi Arabia. The medical charts were reviewed and evaluated based on the performance of the recommended baseline and follow-up of chest X-ray (CXR), liver function test (LFT), thyroid function test (TFT) and electrocardiogram (ECG). The continuous variables were analyzed and presented as mean ± SD and the categorical variables were presented as percentages.

Results
Over the study period, 143 eligible participants on amiodarone therapy were included, with an average of 165 ± 207 days on amiodarone. Of patients, 36.4% had the entire recommended baseline assessments before initiating amiodarone. Our results indicated optimal compliance rates to the baseline tests of CXR (79.7%), LFT (79.7%) and ECG (86.7%). However, there was a lower compliance rate to TFT recommendations (40.6%). The compliance rate to the guideline recommendations related to the follow-up tests was minimal. On-going monitoring performance rates were 47.6% of CXR, 49% of LFT, 54.5% of ECG and 22.4% of TFT.

Conclusion
The compliance with the guideline recommendations related to amiodarone baseline assessments was optimal for all the baseline tests, except for TFT. However, the proportion of patients who received all the recommended baseline assessments was minimal. In addition, the performance of on-going monitoring was suboptimal for all the follow-up tests. Improvements could be made by establishing a local protocol for amiodarone monitoring and pharmacists participating in amiodarone therapy assessments.
Angle-to-angle and spur-to-spur distance analysis with high-resolution optical coherence tomography
Authors: Montés-Micó Robert , Tañá-Rivero Pedro , Aguilar-Córcoles Salvador , Ruiz-Santos María , Rodríguez-Carrillo María Dolores , Ruiz-Mesa Ramón 
Published: August 2020

Abstract
Background
To measure angle-to-angle (ATA) and spur-to-spur (STS) distances along six meridians using high-resolution swept-source optical coherence tomography (SS-OCT) and to compare those values with horizontal white-to-white (WTW) distance.

Methods
68 eyes from 68 patients were quantitatively assessed with the Anterion SS-OCT (Heidelberg Engineering, Heidelberg, Germany). ATA and STS distances were measured with the SS-OCT’s B-Scan in six cross-sectional images corresponding to the vertical (6–12 o’clock), 1–7 o’clock, 2–8 o’clock, horizontal (3–9 o’clock), 4–10 o’clock and 5–11 o’clock meridians. WTW was measured horizontally with the device’s infrared camera. A Pearson correlation analysis was carried out to compare ATA and STS distances with WTW.

Results
The largest values were found for the vertical meridian and the shortest for the 2–8 o’clock meridian, both for ATA and STS distances. No statistically significant differences were found between WTW, ATA and STS along the horizontal meridian (p > 0.1). However, ATA and STS showed statistically significant differences elsewhere, except for the horizontal and the 2–8 o’clock meridians (p > 0.05). Moreover, we found that ATA and STS varied significantly depending on the meridian being assessed, except for ATA at 4–10 versus 3–9 o’clock and for STS at 4–10 versus 3–9 o’clock and at 3–9 versus 2–8 o’clock (p > 0.1). R2 values ranged from 0.49 to 0.75 for ATA and STS at the different meridians, showing the best correlation at 3–9 o’clock meridian (0.64 and 0.75, respectively) and the worst at 6–12 o’clock meridian (R2 = 0.49 for both ATA and STS).

Conclusions
ATA and STS distances vary radially, thus showing that the anterior chamber is vertically oval. Therefore, it is advisable to measure these two distances along the meridian to be used.
Potential of sea buckthorn-based ingredients for the food and feed industry – a review
Authors: Vilas-Franquesa Arnau , Saldo Jordi , Juan Bibiana 
Published: August 2020

Abstract
Food industries seek to incorporate nutritious ingredients as they could bring added value to the final food products. One of the most interesting options is that sea buckthorn contains high concentrations of vitamin C, carotenoids, tocopherols, and other bioactive compounds, in addition to the unique lipid profile in the berry pulp, seed, and peel. This review summarizes the state-of-the-art of potential applications of sea buckthorn within the food and feed industry based on previously described applications. Products such as cheese, yoghurt or beverages already benefit from its application. Moreover, using sea buckthorn in feed products also derives into higher quality final products (e.g. meat quality, egg quality). Poultry, pig, and fish farming have been studied for that purpose. Despite all the accumulated articles depicted in the present review, the use of this fruit in food product formulation is nowadays scarce. New options for food product development with sea buckthorn are herein discussed.

Graphical abstract
Role, path, and vision of “5G + BDS/GNSS”
Authors: Liu Jingnan , Gao Kefu , Guo Wenfei , Cui Jingsong , Guo Chi 
Published: August 2020

AbstractCommunication, positioning, navigation, and decision-making abilities have evolved into Positioning, Navigation, and Timing (PNT) intelligence during the long process of human migration and hence promoted human evolution. This article defines intelligence and smartness from the perspective of biological intelligence. New requirements as a result of the development of communication, navigation, time service, and decision making are identified in this study. The article points out that there are many radio PNT service methods, such as 5G, the new-generation high-speed communication networks and the low-latency and ubiquitous mobile communication networks as well as Global Navigation Satellite System (GNSS), but the integrated application is especially important in providing technical support for the adjustment and control of the physical world by intelligent sensing, cognition, decision-making, and precise coordination. The fusion of 5G and GNSS [including BeiDou Navigation Satellite System (BDS)] information with the corresponding equipment can be embedded into a machine to make it intelligent. Furthermore, the fused information of 5G and GNSS together with the environment information may extend human perception and physical world control ability in terms of time and space scale. It will help to develop critical information infrastructure in the age of intelligence, which will also extend the definition of artificial intelligence. Additionally, the “5G + BDS/GNSS” fusion path is analyzed explicitly herein in terms of realization methods, information processing, and new application services. On the whole, the application of “5G + BDS/GNSS + satellite-based communication” as a critical infrastructure for land, sea, air, space and network spatiotemporal control rights is proposed.
Pharmacological management of comorbid obsessive–compulsive disorder and chronic non-affective psychosis
Authors: Udo Itoro , McDaniel Carol , Chima Chidi 
Published: August 2020

SUMMARYThe comorbidity of obsessive–compulsive symptoms (OCS) in the context of schizophrenia is often not recognised by clinicians, and patients may not report these symptoms until they become severe. However, there is a reported prevalence of 10–24% for obsessive–compulsive disorder (OCD) in schizophrenia and related disorders. The onset of OCS/OCD has been noted to occur both before and after the diagnosis of schizophrenia or schizoaffective disorder. It has also been known to occur following commencement of treatment with antipsychotic medications, especially clozapine. Current literature provides limited guidance for treatment. Review of the current evidence supports: addition of selective serotonin reuptake inhibitors (SSRIs) to antipsychotics; addition of aripiprazole, amisulpride or lamotrigine; or reduction in the dosage of clozapine. There is also evidence supporting the addition of cognitive–behavioural therapy and electroconvulsive therapy (ECT). The SSRIs that are evidenced to be useful are fluvoxamine, escitalopram, sertraline and paroxetine. More studies are needed to expand the evidence base. Early targeted interventions are recommended.
Virtual psychiatric care fast-tracked: reflections inspired by the COVID-19 pandemic
Authors: Rosic Tea , Lubert Sandra , Samaan Zainab 
Published: August 2020

Summary
For many patients and healthcare providers, the move to virtual psychiatric care has been fast-tracked by the COVID-19 pandemic. In this article, we consider a patient perspective and a provider perspective on the transition to virtual psychiatric care and its strengths and limitations, as well as a call for much-needed future research.
Switch Control Inhibition of KIT and PDGFRA in Patients With Advanced Gastrointestinal Stromal Tumor: A Phase I Study of Ripretinib
Authors: Janku Filip , Abdul Razak Albiruni R. , Chi Ping , Heinrich Michael C. , von Mehren Margaret , Jones Robin L. , Ganjoo Kristen , Trent Jonathan , Gelderblom Hans , Somaiah Neeta , Hu Simin , Rosen Oliver , Su Ying , Ruiz-Soto Rodrigo , Gordon Michael , George Suzanne 
Published: August 2020

PURPOSE In advanced gastrointestinal stromal tumor (GIST), there is an unmet need for therapies that target both primary and secondary mutations of pathogenic KIT/PDGFRA oncoproteins. Ripretinib is a novel switch-control kinase inhibitor designed to inhibit a wide range of KIT and PDGFRA mutations. PATIENTS AND METHODS This first-in-human, to our knowledge, phase I study of ripretinib (ClinicalTrials.gov identifier: NCT02571036) included a dose-escalation phase and subsequent expansion phase at the recommended phase II dose (RP2D). Eligible patients included those with advanced GIST, intolerant to or experienced progression on ≥ 1 line of systemic therapy, and other advanced malignancies. Safety, dose-limiting toxicities (DLTs), maximum-tolerated dose (MTD), and preliminary antitumor activity were evaluated. RESULTS At data cutoff (August 31, 2019), 258 patients (n = 184 GIST) were enrolled, with 68 patients in the dose-escalation phase. Three DLTs were reported: grade 3 lipase increase (n = 2; 100 mg and 200 mg twice a day) and grade 4 increased creatine phosphokinase (n = 1; 150 mg once daily). MTD was not reached (maximum dose evaluated, 200 mg twice a day); 150 mg once daily was established as the RP2D. The most frequent (> 30%) treatment-emergent adverse events in patients with GIST receiving ripretinib 150 mg once daily (n = 142) were alopecia (n = 88 [62.0%]), fatigue (n = 78 [54.9%]), myalgia (n = 69 [48.6%]), nausea (n = 65 [45.8%]), palmar-plantar erythrodysesthesia (n = 62 [43.7%]), constipation (n = 56 [39.4%]), decreased appetite (n = 48 [33.8%]), and diarrhea (n = 47 [33.1%]). Objective response rate (confirmed) of 11.3% (n = 16/142) ranging from 7.2% (n = 6/83; fourth line or greater) to 19.4% (n = 6/31; second line) and median progression-free survival ranging from 5.5 months (fourth line or greater) to 10.7 months (second line), on the basis of investigator assessment, were observed. CONCLUSION Ripretinib is a well-tolerated, novel inhibitor of KIT and PDGFRA mutant kinases with promising activity in patients with refractory advanced GIST.
Diverse cellular functions of barrier-to-autointegration factor and its roles in disease
Authors: Sears Rhiannon M. , Roux Kyle J. 
Published: August 2020

ABSTRACT
Barrier-to-autointegration factor (BAF; encoded by BANF1) is a small highly conserved, ubiquitous and self-associating protein that coordinates with numerous binding partners to accomplish several key cellular processes. By interacting with double-stranded DNA, histones and various other nuclear proteins, including those enriched at the nuclear envelope, BAF appears to be essential for replicating cells to protect the genome and enable cell division. Cellular processes, such as innate immunity, post-mitotic nuclear reformation, repair of interphase nuclear envelope rupture, genomic regulation, and the DNA damage and repair response have all been shown to depend on BAF. This Review focuses on the regulation of the numerous interactions of BAF, which underlie the mechanisms by which BAF accomplishes its essential cellular functions. We will also discuss how perturbation of BAF function may contribute to human disease.
Χαρισματικά παιδιά : Αυτοεκτίμηση και σχολική υποεπίδοση
Authors: Κούρτη Παναγιώτα , Μαλαματένια Μαρία 
Published: August 2020

Σκοπός της παρούσας εργασίας αποτελεί η διερεύνηση μέσω βιβλιογραφικής ανασκόπησης, της αυτοεκτίμησης των χαρισματικών παιδιών και της συσχέτισης της χαρισματικότητας με την ακαδημαϊκή τους πορεία .Ως χαρισματικά, ορίζονται τα παιδιά τα οποία έχουν μία ή περισσότερες νοητικές ικανότητες και ταλέντα, αναπτυγμένα σε βαθμό που υπερβαίνει τα προσδοκώμενα για την ηλικιακή τους ομάδα. Αυτοεκτίμηση είναι η εικόνα που έχει ο καθένας για τον εαυτό του και η αίσθηση της αξίας του. Σε ορισμένες μελέτες καταγράφεται θετική αυτοεικόνα και υψηλή αυτοεκτίμηση για την ακαδημαϊκή επιτυχία στα χαρισματικά παιδιά, ενώ σε άλλες δυσαρέσκεια σε σχέση με τις προσωπικές επιδόσεις και αρνητική αυτοεικόνα. Επίσης, παρατηρείται συχνά αναντιστοιχία νοητικού δυναμικού και σχολικής επίδοσης. Παράγοντες ατομικοί και περιβαλλοντικοί φαίνεται να διαδραματίζουν σημαντικό ρόλο στη σχολική υποεπίδοση των χαρισματικών παιδιών. Στους ατομικούς συγκαταλέγονται ο διαφορετικός τρόπος προσέγγισης της μάθησης, η δυσκολία στη σύναψη φιλικών σχέσεων με συνομηλίκους, η εξωτερική έδρα ελέγχου, η χαμηλή αυτοεκτίμηση, οι υψηλές προσδοκίες από τον εαυτό και τους άλλους. Στην υποεπίδοση συμβάλλει η έλλειψη προκλήσεων στο σχολικό περιβάλλον και το συμβατικό σχολικό πλαίσιο. Επιπροσθέτως, μια κατηγορία μαθητών που μπορεί να εμφανίσει χαμηλά επίπεδα σχολικής επιτυχίας είναι οι «διπλά ιδιαίτεροι μαθητές», όρος ο οποίος αναφέρεται στα χαρισματικά παιδιά με ειδικές εκπαιδευτικές ανάγκες. Η χάραξη εκπαιδευτικής πολιτικής προσαρμοσμένης στις ιδιαιτερότητες των χαρισματικών μαθητών, κρίνεται αναγκαία κι επιβεβλημένη.
«Η Αξιοποίηση του Παραμυθιού και του Θεατρικού παιχνιδιού στην Εργοθεραπευτική Παρέμβαση στο Νηπιαγωγείο»
Authors: Παπακίτσου Βασιλική Ι. 
Published: August 2020

Η παρούσα εργασία αποτελεί μία εργοθεραπευτική παρέμβαση που αξιοποιεί δημιουργικά μορφές της Τέχνης, ως μέσα θεραπείας, σε μαθητές με Μαθησιακές Δυσκολίες και ΔΕΠ-Υ, Ιδιωτικού Νηπιαγωγείου του νομού Αττικής. Οι εκπαιδευόμενοι σε συνεργασία με την εκπαιδεύτρια δημιούργησαν ομάδες με ειδικά σχεδιασμένα εκπαιδευτικά προγράμματα, προσαρμοσμένα στα ιδιαίτερα χαρακτηριστικά, τις ικανότητες και τις δυσκολίες των μαθητών. Ο ρόλος της εργοθεραπείας αποδεικνύεται εξαιρετικά σημαντικός βοηθώντας και υποστηρίζοντας συστηματικά, οργανωμένα και αποτελεσματικά τα παιδιά που παρουσιάζουν ποικίλες ψυχοκοινωνικές, συναισθηματικές, γνωστικές δυσλειτουργίες. Το παραμύθι, το θεατρικό παιχνίδι, το παιχνίδι ρόλων, συνιστούν τα πλέον κατάλληλα μέσα προκειμένου ο εργοθεραπευτής, αξιοποιώντας τα κατάλληλα, να ενισχύσει την αυτοπεποίθηση των παιδιών, να βοηθήσει στον αγώνα τους για προσαρμογή, αναπλήρωση και ανεξαρτητοποίηση. Στόχος είναι οι μαθητές/τριες να κοινωνικοποιηθούν, να καλλιεργήσουν δεξιότητες γλωσσικές, γνωστικές, ψυχοκοινωνικές, ομαδικού πνεύματος, οπτικοκινητικού συντονισμού. Παράλληλα, να κατανοούν τη συμβολική – μεταφορική διάσταση της γλώσσας, κινητοποιώντας τους μηχανισμούς προβολής και ταύτισης, έκφρασης, διαχείρισης και επεξεργασίας συναισθημάτων και ενδοψυχικών συγκρούσεων. Επιλέχθηκαν τα έργα: Παραμύθια: Αισώπου Μύθοι: «Ο Ψεύτης Βοσκός». Τριβιζά: «Τα τρία μικρά λυκάκια». Ποίημα: Γ. Δροσίνη: «Η Αλεπού Καλόγρια». Μουσική: Μελοποιημένο το ποίημα και επιλεγμένα αποσπάσματα σε μουσική Τ. Μωράκη.
Implantation of cryopreserved umbilical cord allograft in hard-to-heal foot wounds: a retrospective study
Authors: Raphael Allen , Grimes Laura 
Published: August 2020

Objective: The objective of this study was to assess the clinical effectiveness of surgically implanted cryopreserved human umbilical cord allograft in treating hard-to-heal wounds with and without osteomyelitis. Method: In this single-centre, retrospective investigation, wounds (average size 6.9±10.1cm2) were included for analysis that had failed prior standard wound care for an average of 14.4±8.0 weeks. Results: After surgical implantation of cryopreserved umbilical cord between the deep tissue planes, 20 (95%) of the 21 wounds included in the study achieved complete closure in a median time of 7.8 weeks (range: 1–68) despite presence of residual osteomyelitis in 15 cases. A total of 12 wounds (57.1%) healed by 12 weeks, and 16 (76.2%) wounds healed by 24 weeks. A patient who presented with a limb-threatening calcaneal ulcer that was complicated by osteomyelitis at the time of treatment required subsequent amputation. No adverse events or complications related to cryopreserved umbilical cord were observed. Conclusion: The results suggest that surgical implantation of cryopreserved umbilical cord allograft may be a safe and effective treatment in improving healing of hard-to-heal wounds. Further prospective, randomised controlled trials are warranted.
Ultra-precise optical-frequency stabilization with heterogeneous III–V/Si lasers
Authors: Stern Liron , Zhang Wei , Chang Lin , Guo Joel , Xiang Chao , Tran Minh A. , Huang Duanni , Peters Jonathan D. , Kinghorn David , Bowers John E. , Papp Scott B. 
Published: August 2020

The demand for low-noise, continuous-wave, frequency-tunable lasers based on semiconductor integrated photonics has advanced in support of numerous applications. In particular, an important goal is to achieve a narrow spectral linewidth, commensurate with bulk-optic or fiber-optic laser platforms. Here we report on laser-frequency-stabilization experiments with a heterogeneously integrated III/V-Si widely tunable laser and a high-finesse, thermal-noise-limited photonic resonator. This hybrid architecture offers a chip-scale optical-frequency reference with an integrated linewidth of 60 Hz and a fractional frequency stability of

2.5
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10

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13

at 1 s integration time. We explore the potential for stabilization with respect to a resonator with lower thermal noise by characterizing laser-noise contributions such as residual amplitude modulation and photodetection noise. Widely tunable, compact and integrated, cost-effective, stable, and narrow-linewidth lasers are envisioned for use in various fields, including communication, spectroscopy, and metrology.
High-energy, tunable, long-wave mid-infrared optical parametric oscillator based on BaGa4Se7 crystal
Authors: Xu Degang , Zhang Jiaxin , He Yixin , Wang Yuye , Yao Jiyong , Guo Yangwu , Yan Chao , Tang Longhuang , Li Jining , Zhong Kai , Wu Yicheng , Yao Jianquan 
Published: August 2020

A high-energy, tunable, long-wave mid-infrared optical parametric oscillator (OPO) based on the

B
a
G

a

4

S

e

7

crystal was demonstrated in this Letter with 1064 nm laser pumping. The mid-infrared OPO was designed as a double-pass single resonant oscillator (DP-SRO) to reduce the threshold and improve the outputs. Further optimization on the cavity length was theoretically and experimentally studied. With a short cavity length of 30 mm, the output energy of over 1 mJ/pulse at 11 µm was obtained with the pump energy of 39.5 mJ/pulse. In addition, a wide tuning range of 8–14 µm was experimentally achieved by rotating the

B
a
G

a

4

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crystal.
Extractos de las Hojas de Salvia Officinalis y Sambucus Peruviana H.B.K. como Inhibidores de Incrustaci´on
Authors: Castillo Campos Luis Antonio , Barreto Steevenson José 
Published: August 2020

Contexto: El fen´omeno de formaci´on de las incrustaciones se ha convertido en uno de los problemas operacionales con mayor frecuencia de ocurrencia en la industria petrolera, y la b´usqueda de fuentes innovadoras de mitigaci´on ha resultado ser el horizonte al cual han apuntado las empresas del ´area. Por ello, en esta investigaci´on se eval´ua el efecto antiincrustante que presentaron los extractos de las hojas de Salvia officinalis y Sambucus peruviana H.B.K.
M´etodo: Se realiz´o la caracterizaci´on fisicoqu´ımica de una muestra de agua de producci´on del Campo Oritupano y se obtuvieron los extractos, para luego ser identificadas sus propiedades f´ısicas. Posterior a ello, se determin´o el desempe˜no inhibitorio de cada producto natural en conjunto con un agente comercial, todo a trav´es de la aplicaci´on de la Norma NACE TM0374-2007, adem´as de aplicar un an´alisis estad´ıstico para visualizar las diferencias significativas que pudiesen estar presentes entre las eficiencias experimentales y comerciales.
Resultados: Los extractos de Salvia officinalis y Sambucus peruviana H.B.K empleados como antiincrustantes exteriorizaron resultados de pH de car´acter ´acido y viscosidades por debajo de los 2 cSt, mostrando rendimientos m´aximos de 87,27% y 90,91% para las soluciones a base de sa´uco y salvia respectivamente, y comportamientos estad´ısticos similares al producto comercial referencial.
Conclusiones: En t´erminos cuantitativos, el prospecto a base de salvia result´o m´as efectivo al evaluarlo en la muestra de agua de producci´on del Campo Oritupano, mostrando un comportamiento directamente proporcional concentraci´on-eficiencia, adem´as de exponerse con caracter´ısticas m´as acordes a un bioinhibidor de incrustaciones de carbonato de calcio, aunque con proporci´on de s´olidos que deber´ıan disminuirse a´un m´as, requiriendo que en un futuro se mejore esta caracter´ıstica y se pueda medir la acci´on conjunta de ambos extractos en la prevenci´on de las incrustaciones, tanto experimentalmente como en campo.