bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent advances in ion sensing with conducting polymers
Authors: Sethumadhavan Vithyasaahar , Rudd Sam , Switalska Eliza , Zuber Kamil , Teasdale Peter , Evans Drew 
Published: November 2019

AbstractIons are present throughout our environment—from biological systems to agriculture and beyond. Many important processes and mechanisms are driven by their presence and their relative concentration. In order to study, understand and/or control these, it is important to know what ions are present and in what concentration—highlighting the importance of ion sensing. Materials that show specific ion interaction with a commensurate change in measurable properties are the key components of ion sensing. One such type are conducting polymers. Conducting polymers are referred to as ‘active’ because they show observable changes in their electrical and optical (and other) properties in response to changing levels of doping with ions. For example, p-type conducting polymers such as poly(3,4-ethylenedioxythiophene) and polypyrrole, can transition from semi-conducting to metallic in response to increasing levels of anions inserted into their structure. Under certain circumstances, conducting polymers also interact with cations—showing their utility in sensing. Herein, recent advances in conducting polymers will be reviewed in the context of sensing ions. The main scope of this review is to critically evaluate our current understanding of ion interactions with conducting polymers and explore how these novel materials can contribute to improving our ion-sensing capabilities.
Connecting theory and practice in teacher education: English-as-a-foreign-language pre-service teachers’ perceptions of practicum experience
Authors: Yin Judy 
Published: November 2019

AbstractThe present study explores the perceptions of pre-service teachers regarding their experiences in the university teacher-training course during the practicum. In particular, the study focuses on how the pre-service teachers perceived the effects of the university course, as they tried to connect theory and practice during the practicum. A total of 15 participants enrolled in the methodology course for teaching speaking attended a 4-week practicum in secondary schools. They recorded their reflections on their teaching experiences in their reflective journals and they were interviewed after the practicum. The results of the study showed that the university course prepared them the fundamental skills to prepare for lessons and reflect on their teaching practice. However, the course failed to prepare them adequately to cope with the realities of the classroom context, as the university course only provided them with an idealistic view of the classroom. The implication of the study suggests ways to better connect university courses with the actual classroom practices to provide pre-service teachers the maximum support to practicalize their knowledge during the practicum.
Right ventricular 2D speckle-tracking echocardiography in children with osteosarcoma under chemotherapy
Authors: Khairat Ibtsam , Khalfallah Mohamed , Shaban Aliaa , Farag Ibrahim Abu , Elkady Asmaa 
Published: November 2019

Abstract
Background
Cardiotoxicity from anthracyclin chemotherapy is a leading cause of death in patients with cancer. Therefore, left ventricular (LV) function is routinely assessed during protocol to detect cardiotoxicity; however, animal studies suggest that right ventricular (RV) function may be also impaired. So, our objective was to investigate the incidence of RV dysfunction in children with osteosarcoma receiving anthracyclines and to highlight the role of 2D STE in early detection of RV dysfunction.

Results
RV function was affected by anthacyclines through direct cardiotoxic effect on RV myocardium without simultaneous derangement of LV function. Furthermore, there is a direct proportion between the incidence of RV dysfunction and the cumulative dose of anthracyclines. At the first echo follow-up at 10th week, 7 patients had impaired RV GLS in comparison to baseline study. At 20th week, the number of patients with impaired RV strain increased to 10. At 29th week, it reaches 12 patients. This effect was early detected by RV 2DSTE before adversely affecting TAPSE and FAC. The incidence of RV dysfunction from anthracyclines was around 12%, and the recovery rate was around 8% in 3 months after completion of chemotherapy.

Conclusion
RV 2DSTE is the best modality to detect early affection of RV function in comparison with other modalities. RV function decreases early even before derangement of LV function. Accordingly, it should be assessed separately in all patients who received anthracyclines even without evident LV affection.
Detection of positively remodeled coronary artery lesions by multislice CT and its impact on cardiovascular future events
Authors: Galal Haitham , Rashid Tarek , Alghonaimy Wesam , Kamal Diaa 
Published: November 2019

Abstract
Background
Positive arterial remodeling may be a characteristic of early proliferative lesions. The study was done to identify the different morphological characteristics of the positively remodeled coronary lesions, and causing non-significant arterial stenosis, as detected by multislice computed tomography coronary angiography (MSCT CA) and its predictors of cardiovascular clinical events at 90-day follow-up. The study included 55 patients who were candidate for MSCT CA and found to have a single-vessel disease with less than 70% stenosis positively remodeled lesions. The most expansive or solitary lesion was selected for each patient. Positive remodeling defined as remodeling index (RI) > 1.05. We followed the patients clinically for 90 days.

Results
Twenty-four patients had a history of acute coronary syndrome at initial presentation with normal LV systolic function for all studied patients. Dyslipidemia was found in 37 patients (67.3%) while diabetes was found in 29 patients (52.7%). The majority of the lesions were found in the proximal LAD (43.6%). The mean calculated remodeling index was 1.41 ± 0.25. At the end of 90 days, 25 patients had clinical events in the form of unstable coronary syndromes, coronary interventions, or coronary angiography related to the index lesion. The predictors of clinical events were duration of DM, higher degree of luminal narrowing, calculated wall/lumen area percentage, plaque burden, plaque-specific calcification, and total calcium score at remodeling site as well as a lower percentage of low-attenuation plaque area. The mean calculated wall/lumen area percentage was 263.72 ± 122.71%. A cut-off value of > 226% was found a predictor for clinical events. The mean plaque burden percentage was 69.72 ± 9.71%, a value of > 69% was found a predictor for clinical events. Both values had a sensitivity of 68% and specificity of 86.6% and PPV of 81%. Positively remodeled lesions with a high RI > 1.4 were correlated with patients who had acute coronary syndrome on their initial presentation.

Conclusion
Different morphological characteristics of positively remodeled non-occlusive atherosclerotic plaques as detected by multislice CT coronary angiography may be good potential predictors of future cardiovascular events.
Health-Related Quality of Life With Carboplatin-Paclitaxel or nab-Paclitaxel With or Without Pembrolizumab in Patients With Metastatic Squamous Non–Small-Cell Lung Cancer
Authors: Mazieres Julien , Kowalski Dariusz , Luft Alexander , Vicente David , Tafreshi Ali , Gümüş Mahmut , Laktionov Konstantin , Hermes Barbara , Cicin Irfan , Rodríguez-Cid Jerónimo , Wilson Jonathan , Kato Terufumi , Ramlau Rodryg , Novello Silvia , Reddy Sreekanth , Kopp Hans-Georg , Piperdi Bilal , Li Xiaodong , Burke Thomas , Paz-Ares Luis 
Published: November 2019

PURPOSE In the phase 3 KEYNOTE-407 study, the addition of pembrolizumab to carboplatin-paclitaxel/nab-paclitaxel significantly improved overall survival, progression-free survival, and objective response rate in patients with previously untreated metastatic squamous non–small-cell lung cancer (NSCLC), with little impact on severe toxicity. We present patient-reported outcomes (PROs) from KEYNOTE-407. METHODS Patients were randomly assigned to receive 4 cycles of pembrolizumab 200 mg or placebo once every 3 weeks plus carboplatin plus paclitaxel or nab-paclitaxel, followed by pembrolizumab or placebo for an additional 31 cycles. Health-related quality of life (HRQoL) was evaluated using the European Organisation for Research and Treatment of Cancer Treatment of Cancer Quality of Life Questionnaire-Core 30 (QLQ-C30) and Quality of Life Questionnaire-Lung Cancer Module 13 (QLQ-LC13). Key PRO endpoints were change from baseline to weeks 9 and 18 (during and after platinum therapy) in the QLQ-C30 global health status/quality of life (GHS/QoL) score and time to deterioration in the composite endpoint of cough, chest pain, or dyspnea from the QLQ-C30 and QLQ-LC13. Two-sided, nominal P values are provided. RESULTS A total of 554 and 553 patients completed ≥ 1 QLQ-C30 or ≥ 1 QLQ-LC13 assessment, respectively. GHS/QoL score improved for the pembrolizumab-combination group (least squares [LS] mean [95% CI] change from baseline: week 9, 1.8 [−0.9 to 4.4]; week 18, 4.3 [1.7 to 6.9]) and deteriorated in the placebo-combination group (week 9, −1.8 [−4.4 to 0.7]; week 18, −0.57 [−3.3 to 2.2]). Between-group differences were improved for the pembrolizumab-combination group (difference in LS mean scores: week 9, 3.6 [95% CI, 0.3 to 6.9], nominal P = .0337; week 18, 4.9 [1.4 to 8.3], nominal P = .0060). Median time to deterioration in cough, chest pain, or dyspnea was not reached in either group (hazard ratio, 0.79; 95% CI, 0.58 to 1.06]; nominal P = .125). CONCLUSION Addition of pembrolizumab to chemotherapy maintained or improved HRQoL measurements relative to baseline and improved HRQoL versus chemotherapy alone at weeks 9 and 18. These results support use of pembrolizumab plus chemotherapy as first-line therapy for metastatic squamous NSCLC.
Use of PCSK9 Inhibitor in a Mexican Boy with Compound Heterozygous Familial Hypercholesterolemia: A Case Report
Authors: Ceballos-Macías José Juan , Madriz-Prado Ramón , Vázquez Cárdenas Norma Alejandra , Aguilar-Salinas Carlos , Tusié-Luna Maria Teresa , Flores-Real Jorge Alberto , Ortega-Gutiérrez Guillermo , Vargas-Sánchez Joel , Lara-Sánchez Carolina , Hernández-Moreno Alfredo 
Published: November 2019

Abstract
We report on the case of an 8-year-old Mexican male, with a 3-year-old clinical diagnosis of familial hypercholesterolemia, and the difficulties encountered in his treatment while in our care. His treatment started with a regimen consisting of ezetimibe/simvastatin, cholestyramine, and a dietary plan of 1600 calories, with a limited intake of 200 mg of cholesterol per day. Problems arose when the patient’s low-density lipoprotein cholesterol (LDL) levels did not meet ideal targets, which prompted the use of LDL cholesterol apheresis (not available in Mexico) for 6 months. As a last resort, PCSK9 inhibitors were administered but the LDL levels remained in the 600 mg/dL range. AmbryGenetics conducted a genetic test employing the Sanger method. The results suggested that there were 2 different mutations for each allele of the same LDL receptor gene (c.249delTinsGG and p.(Cys109Arg)), located in exons 3 and 4, respectively. We identified compound heterozygous mutations in our index case, with him having both the p.C109R mutation (from the maternal lineage), as well as a c.249delTinsGG mutation (from the paternal lineage). The p.C109R mutation has been previously reported, not only in Mexico, but in European regions (Germany, Czech Republic, Ireland, Italy) as well. Functional studies indicated a residual enzymatic activity of 15% to 30% for heterozygotes. To date, the variant c.249delTinsGG has not been reported. This case study illustrates the fact that in Mexico there are limited options available for treatment in such a scenario. As medical professionals, we are limited by the tools at our disposal.
THE RESEARCH OF INTER-PHASE INTERACTION IN SOL-SILICATE PAINTS
Authors: Логанина В.И. , Loganina Valentina , Мажитов Еркебулан , Mazhitov Erkebulan 
Published: November 2019

It is proposed to use polysilicate solutions obtained by mixing liquid glass and silicic acid sol as a binder at silicate paints manufacturing. Information is provided on the mechanism for increasing the operational properties of coatings based on silicate paint sol. It has been revealed that the polysilicate solutions form films characterized by higher tensile strength due to the increase of the share of silicic anions’ high-polymer fractions in the structure of polysilicate binder in comparison with liquid glass.
The results of studying the interphase interaction between the pigment and the film-forming agent are presented. It is shown that potassium polysilicate solutions form a smaller contact angle on the surface of the pigment (filler) and are characterized with greater work of wetting and adhesion to the filler (pigment).
A Description of Parent Input in IEP Development Through Analysis IEP Documents
Authors: Kurth Jennifer A. , McQueston Jessica A. , Ruppar Andrea L. , Toews Samantha Gross , Johnston Russell , McCabe Katie M. 
Published: November 2019

Abstract
Parent input in individualized education program (IEP) development is the clear expectation in U.S. education law. Every IEP team must include parents, and their input must be equally considered when developing IEPs. The present study used content analysis of 88 IEPs of students with intellectual and developmental disabilities to explore team membership, concerns parents raised during IEP meetings, and evidence that parent concerns and priorities are reflected in IEP goals and supplementary aids and services. Findings reveal that although parents express a range of concerns and priorities, these are translated into goals or services only two thirds of the time. We provide implications of these findings for research and practice.
Case Management Workforce Supporting People With Intellectual and Developmental Disabilities: Indications of a New Frontier of the Workforce Crisis
Authors: Bogenschutz Matthew D. , Dinora Parthenia A. , Johnson Khalilah R. 
Published: November 2019

AbstractCase management (CM) is one of the most commonly used services by individuals with intellectual and developmental disabilities (IDD), but little is known about the workers who provide CM. This study used a mixed methods approach to gain understanding of the CM workforce in one U.S. state. An online survey was completed by 35 IDD service directors (87.5% of directors in the state); and 113 CMs and CM supervisors participated in semistructured interviews and focus groups. Results indicated an annual crude separation rate of 28.2%, and participants often complained that turnover resulted in caseload sizes that prevented optimal outcomes for people with IDD. A limited applicant pool, duties focused on regulatory compliance, and inadequate wages were cited as major challenges for CMs.
Feedback and Strategies From People With Intellectual Disability Completing a Personalized Online Weight Loss Intervention: A Qualitative Analysis
Authors: Guerra Nichole , Neumeier William H. , Breslin Lauren , Geer Betty , Thirumalai Mohanraj , Ervin David A. , Rimmer James H. 
Published: November 2019

AbstractCoaching log notes for 15 participants from a 24-week blended online and telehealth randomized controlled trial were analyzed using thematic analysis and analyst triangulation to determine the factors that facilitated participant adherence to weight loss strategies, use of technology, and motivational interviewing. Several participants reported that restricting processed carbohydrates, limiting portion size, and maintaining healthy substitutions were effective nutritional strategies. Participants were less successful with adherence to their exercise goals, often due to time constraints and a lack of support. Results suggested consistent caregiver support improved participants' adherence to weight loss strategies and use of technology. Future programs should address obesity among people with intellectual and developmental disabilities by offering a range of interventions that are customized to their specific weight loss needs.
Macro-conformality of coatings deposited using high-speed spatial plasma-enhanced atomic layer deposition
Authors: Dickey Eric , Niiranen Kalle , Danforth Bryan , Barrow William A. 
Published: November 2019

Rotational spatial plasma-enhanced atomic layer deposition has been used to deposit thin films on half-sphere lenses. Non-uniformity of less than

±
1
%

is demonstrated for

N
b

2

O

5

deposited at 1.4 Å/s and for

S
i
O

2

deposited at 6 Å/s.
Impact of high refractive coating material on the nodular-induced electric field enhancement for near infrared multilayer mirrors
Authors: Stolz Christopher J. , Feigenbaum Eyal 
Published: November 2019

Electric field enhancement due to nodular defects within quarter-wave optical thickness multilayer mirrors is impacted by the inclusion diameter, inclusion depth, inclusion composition, nodular shape, multilayer angular bandwidth, multilayer coating materials, number of layers, angle of incidence, and polarization. In this modeling study, the electric field enhancement for surface inclusions with diameters up to 2 µm irradiated at 1064 nm at either normal or 45 deg incidence is calculated for high refractive index materials over a refractive index range of 1.7–2.3 for oxide materials commonly used in the near infrared. The thicknesses of the multilayer mirror thin films are determined for each high refractive index material by a requirement to meet a 99.5% reflection. The refractive index was found to have a significant impact on the electric field enhancement, which may offer some insight into the optimal material choice to produce high laser damage threshold mirrors.
Tanulási korláttal küzdő tanulók egyes pszichológiai erőforrásainak vizsgálata
Authors: Virág Krisztina , Dudok Réka , Szabó Éva 
Published: November 2019

Kutatásunk célja annak feltárása volt, hogy a tanulási korláttal küzdő és tanulási korláttal nem küzdő diákok pszichológiai erőforrásai különböznek-e egymástól, és ha igen, akkor mely területeken. Nyilvánvaló, hogy a gyengébb tanulmányi eredmények a tanulási korlátokkal küzdő gyerekek esetében összefüggenek képességeik hiányosságaival, eltérő fejlődési ütemükkel, de feltételeztük, hogy léteznek olyan nem specifikus erőforrásbeli különbségek is, amelyek tovább nehezítik a jó iskolai előmenetelt. Úgy véltük, ha sikerül rámutatni ezekre a nem specifikus pszichológiai hiányosságokra, hátrányokra, akkor a tanulási és kognitív képességek fejlesztése mellett ezek erősítése sokat javíthat a tanulási korlátokkal küzdő diákok iskolai teljesítményén. Kérdőíves vizsgálatunkban tanulási korláttal küzdő (N=51) és tipikusan fejlődő diákok (N=51) (korban, nemben illesztett minta) általános énhatékonyságát, általános és tanulmányi felelősségét, valamint proaktív attitűdjét hasonlítottuk össze. A tanulási korláttal küzdő és tipikus fejlődést mutató tanulók eredményeinek összehasonlításából az látszik, hogy a tanulási korlátokkal küzdők alacsonyabb általános énhatékonysággal, valamint magasabb felelősségérzettel rendelkeznek, mint a kontrollcsoportban szereplő diákok. A két csoport proaktivitása nem tért el szignifikánsan. Eredményeink alapján úgy látjuk, hogy a tanulási korlátok leküzdésének segítésében érdemes nagyobb figyelmet fordítani a pszichológiai erőforrások fejlesztésére, valamint további kutatásokkal feltárni ezek más aspektusait is.
Un viaje a través de la utopía: anarquismo, imaginación geográfica y futuros performativos en la obra de Marie-Louise Berneri
Authors: Ferretti Federico 
Published: November 2019

Este articulo aborda los trabajos y archivos de la militante anarquista transnacional Maria Luisa Berneri (1918-1949), autora de un estudio poco conocido pero muy significativo sobre las historias de las utopías y sus espacios. Al ampliar la literatura actual sobre geografías anarquistas, utopismo y sobre la relación entre la geografía y las ‘humanidades’, defiendo que una distinción entre utopías libertarias y utopías autoritarias es esencial para comprender la importancia política del concepto de utopía, que es también un asunto de espacio y de imaginación geográfica. Las críticas de Berneri a la utopía se inspiraron en su anticolonialismo y su antiautoritarismo, centrado especialmente en su original critica de los totalitarismos del siglo XX. Además, propongo una conexión entre abordajes anarquistas, humanistas, culturales e históricos de la geografía para ampliar el campo empírico y teórico de la disciplina y de sus relaciones con las humanidades. Este articulo contribuye también a las investigaciones recientes sobre el anarquismo transnacional, y afirma que la tradición anarquista no puede ser comprendida fuera de sus redes transnacionales, multilingües y cosmopolitas y de sus practicas concretas. Entonces, solo lecturas contextuales, relacionales y sensibles al espacio pueden dar sentido a esta especificidad anarquista.
Interaksi Wilayah di Kawasan Strategis Nasional (Perbatasan) dalam Kerangka Jaringan Perkotaan
Authors: Muazir Syaiful 
Published: November 2019

To support the development of lagging areas (border areas), the Government of Indonesia has encouraged urban areas in the border to become strategic areas with certain development priorities. These specified areas could become a growth center for "transferring" the development outputs to the other areas. One of the border regency in West Kalimantan Province is Sambas Regency. There are two categories of "strategic areas" in this regency, that is Sambas District (the regency’s capital city) as a tourism strategic area, and border area (Temajuk and Aruk) as the National Strategic Activities Center. Expectedly, these two strategic areas could interact more balanced and equally in regional development. This research deals with preliminary exploration which aims to identify the tendency of regional interaction in the strategic areas. Interaction is considerably important for the lagging areas in the border to distribute development outputs from other areas. This study applies the principle approach of network analysis by using different network types such as technical networks (infrastructure), transactional networks, and social networks. The results show that the interaction between developed and lagging areas has not been optimal yet. Sambas District is more attracted to the south closing to the provincial capital city while the border areas more attached to neighboring countries as well as other advanced (internal) areas next to the border.