bluuebunny/crossref_metadata_2025_split huggingface dataset:
Theory of quantum path computing with Fourier optics and future applications for quantum supremacy, neural networks and nonlinear Schrödinger equations
Authors: Gulbahar Burhan 
Published: July 2020

AbstractThe scalability, error correction and practical problem solving are important challenges for quantum computing (QC) as more emphasized by quantum supremacy (QS) experiments. Quantum path computing (QPC), recently introduced for linear optic based QCs as an unconventional design, targets to obtain scalability and practical problem solving. It samples the intensity from the interference of exponentially increasing number of propagation paths obtained in multi-plane diffraction (MPD) of classical particle sources. QPC exploits MPD based quantum temporal correlations of the paths and freely entangled projections at different time instants, for the first time, with the classical light source and intensity measurement while not requiring photon interactions or single photon sources and receivers. In this article, photonic QPC is defined, theoretically modeled and numerically analyzed for arbitrary Fourier optical or quadratic phase set-ups while utilizing both Gaussian and Hermite-Gaussian source laser modes. Problem solving capabilities already including partial sum of Riemann theta functions are extended. Important future applications, implementation challenges and open issues such as universal computation and quantum circuit implementations determining the scope of QC capabilities are discussed. The applications include QS experiments reaching more than $$2^{100}$$2100 Feynman paths, quantum neuron implementations and solutions of nonlinear Schrödinger equation.
Effect of occlusal splint on oxidative stress markers and psychological aspects of chronic temporomandibular pain: a randomized controlled trial
Authors: Alajbeg Iva Z. , Vrbanović Ema , Lapić Ivana , Alajbeg Ivan , Vuletić Lea 
Published: July 2020

AbstractTemporomandibular disorders (TMD), when progress to a chronic state, might contribute to psychosocial or psychological distress. This study aimed to evaluate the effect of stabilization splint (SS) therapy on pain, pain-related disability and psychological traits of chronic TMD patients, as well as to assess selected oxidative stress (OS) biomarkers during 6-month treatment and associate them with the symptoms of anxiety and depression. Thirty-four participants were randomly assigned into two treatment groups [SS and placebo splint (PS)]. Primary outcomes were pain intensity and pain-related disability while secondary outcomes included depressive and anxiety symptoms. The influence of the treatment type was analyzed with regards to the levels of OS biomarkers in saliva. Participants treated with SS demonstrated significantly greater improvement in pain-related disability (Pain-free mouth opening: p = 0.018, η2 = 0.166; Number of disability days: p = 0.023, η2 = 0.155) and greater reduction of depressive symptoms scores (p = 0.007, η2 = 0.207). When compared to the PS group, participants in the SS group showed a significant reduction of oxidant/antioxidant ratio (p = 0.018, η2 = 0.167) at a 3-month follow-up. A stabilization splint provides advantages over PS in the treatment of depressive symptoms and pain-related disability. Furthermore, clinical success in terms of reduction of depressive symptoms, which correlates with the reduction of oxidative stress markers in the SS group, indicates that oxidative stress is related to psychological factors in chronic TMD patients.
Remarkable thermal conductivity enhancement in Ag—decorated graphene nanocomposites based nanofluid by laser liquid solid interaction in ethylene glycol
Authors: Mbambo M. C. , Khamlich S. , Khamliche T. , Moodley M. K. , Kaviyarasu K. , Madiba I. G. , Madito M. J. , Khenfouch M. , Kennedy J. , Henini M. , Manikandan E. , Maaza M. 
Published: July 2020

AbstractWe report on the synthesis and enhanced thermal conductivity of stable Ag-decorated 2-D graphene nanocomposite in ethylene glycol based nanofluid by laser liquid solid interaction. A surfactant free nanofluid of Ag nanoparticles anchored onto the 2-D graphene sheets were synthesized using a two-step laser liquid solid interaction approach. In order to understand a pulsed Nd:YAG laser at the fundamental frequency (λ = 1,064 nm) to ablate Ag and graphite composite target submerged in ethylene glycol (EG) to form AgNPs decorated 2-D GNs-EG based nanofluid. From a heat transfer point of view, it was observed that the thermal conductivity of this stable Ag-graphene/EG is significantly enhanced by a factor of about 32.3%; this is highest reported value for a graphene based nanofluid.
Carbohydrate antigen 125 for mortality risk prediction following acute myocardial infarction
Authors: Falcão Felipe , Oliveira Flávio , Cantarelli Fabiano , Cantarelli Rodigo , Brito Júnior Paulo , Lemos Hygor , Silva Paloma , Camboim Irla , Freire Maria Cleide , Carvalho Osmário , Sobral Filho Dário Celestino 
Published: July 2020

AbstractCarbohydrate antigen 125 (CA125) is a congestion and inflammation biomarker and has been proved to be related to a worse prognosis in heart diseases. However, the precise relationship between elevated CA125 in patients with ST-segment elevation myocardial infarction (STEMI) has not yet been sufficiently studied. We set out to determine the association of CA125 with all-cause mortality at 6 months in STEMI. CA125, N-terminal pro brain natriuretic peptide (NTproBNP) and high sensitive C-reactive protein (hs-CRP) were measured in 245 patients admitted consecutively with STEMI undergoing coronary angioplasty. The mean age in our sample was 63.7 years, 64.9% were males, 28.3% had diabetes and 17.7% presented with acute heart failure (Killip ≥ 2). The median serum level of CA125 was 8.1 U/ml. At 6 months, the rate of all-cause mortality was 18% (44 patients). Receiver operating characteristic curve analysis demonstrated that CA125 presented similar performance to predict mortality as NTproBNP and hs-CRP. Patients with CA125 ≥ 11.48 had a higher rate of mortality (Hazard Ratio = 2.07, 95% confidence interval = 1.13–3.77, p = 0.017) than patients with CA125 < 11.48. This study suggests that elevated CA125 levels might be used to identify patients with STEMI with a higher risk of death at 6 months. CA125 seems to be a similar predictor of mortality compared to NTproBNP and hs-CRP.
Spatiotemporal and hotspot detection of U5-children diarrhea in resource-limited areas of Ethiopia
Authors: Alemayehu Bezuayehu , Ayele Birhanu Teshome , Valsangiacomo Claudio , Ambelu Argaw 
Published: July 2020

AbstractUnder-five children (U5-children) diarrhea is a significant public health threat, where the World Health Organisation (WHO) reported it as the second leading cause of children’s death worldwide. Nearly 1.7 billion cases occur annually with varied temporal and spatial factors. Identification of the spatiotemporal pattern and hotspot areas of U5-children diarrhea can assist targeted intervention and provide an early warning for more effective response measures. This study aimed at examining spatiotemporal variability along with the detection of hotspot areas for U5-children diarrhea in the Bench Maji Zone of southwestern Ethiopia, where resources are limited and cultural heterogeneity is highest. Retrospective longitudinal data of ten years of diarrhea records from January 2008 to December 2017 were used to identify hotspot areas. The incidence rate per 1,000 per year among children was calculated along with seasonal patterns of cases. The spatiotemporal analysis was made using SaTScan version 9.4, while spatial autocorrelations and hotspot identification were generated using ArcGIS 10.5 software. A total of 90,716 U5-children diarrhea cases were reported with an annual incidence rate of 36.1 per 1,000 U5-children, indicating a relative risk (RR) of 1.6 and a log-likelihood ratio (LLR) of 1,347.32 (p < 0.001). The highest incidence of diarrhea illness was recorded during the dry season and showed incidence rate increment from October to February. The risky clusters (RR > 1) were in the districts of Bero, Maji, Surma, Minit Shasha, Guraferda, Mizan Aman Town, and Sheko with annual cases of 127.93, 68.5, 65.12, 55.03, 55.67, 54.14 and 44.97 per 1,000, respectively. The lowest annual cases reported were in the four districts of Shay Bench, South Bench, North Bench, and Minit Goldiya, where RR was less than a unit. Six most likely clusters (Bero, Minit Shasha, Surma, Guraferda, South Bench, and Maji) and one lower RR area (North Bench) were hotspot districts. The U5-children's diarrhea in the study area showed an overall increasing trend during the dry seasons with non-random distribution over space and time. The data recorded during ten years and analyzed with the proper statistical tools helped to identify the hotspot areas with risky seasons where diarrhea could increase.
Using larval barcoding to estimate stomatopod species richness at Lizard Island, Australia for conservation monitoring
Authors: Palecanda Sitara , Feller Kathryn D. , Porter Megan L. 
Published: July 2020

AbstractStomatopods (Crustacea, Stomatopoda) are well studied for their aggressive behavior and unique visual system as well as their commercial importance in Asian and European countries. Like many crustaceans, stomatopods undergo indirect development, passing though several larval stages before reaching maturity. Adult stomatopods can be difficult to catch due to their inaccessible habitats and cryptic coloration. By sampling larvae from the planktonic community, less effort is required to obtain accurate measures of species richness within a region. Stomatopod larvae were collected between 2006 and 2015 from the waters around the Lizard Island reef platform in Eastern Australia. Cytochrome oxidase I (COI) mitochondrial DNA sequences were generated from each larval sample and compared to a database of COI sequences tied to adult specimens. Of the 20 species collected from Lizard Island as adults which have COI data available, 18 species were identified from larval sampling. One additional species identified from larval samples, Busquilla plantei, was previously unknown from Lizard Island. Nine larval OTUs were found not to match any published adult sequences. Sampling larval stomatopod populations provides a comparable picture of the adult population to benthic sampling methods and may include species richness beyond what is measurable by sampling adult populations.
A new species of early-diverging Sauropodiformes from the Lower Jurassic Fengjiahe Formation of Yunnan Province, China
Authors: Peyre de Fabrègues Claire , Bi Shundong , Li Hongqing , Li Gang , Yang Lei , Xu Xing 
Published: July 2020

AbstractSauropodomorpha were herbivorous saurischian dinosaurs that incorporate Sauropoda and early-diverging sauropodomorphs. The oldest sauropodomorph remains are known from Late Triassic deposits, most of them Gondwanan. The Laurasian record comprises some Triassic forms, but the bulk is Jurassic in age. Among the 14 Jurassic non-sauropodan sauropodomorphs from Laurasia described in the past, 8 are from China. Here we describe a new non-sauropodan sauropodomorph,Irisosaurus yimenensisgen. et sp. nov., from the Early Jurassic Fengjiahe Formation of China. Nearly all of the non-sauropodan sauropodomorph genera currently known from China were first reported from the Lufeng Formation. The Fengjiahe Formation is its Southern equivalent, bringing a fauna similar to that of the Lufeng Formation to light. The new genus is defined based on an incomplete but unique maxilla, with a premaxillary ramus higher than long prior to the nasal process, a large and deep neurovascular foramen within the perinarial fossa, and a deep perinarial fossa defined by a sharp rim. Phylogenetic analysis placesIrisosaurusat the very base of Sauropodiformes, as the sister-taxon of the Argentinean genusMussaurus. This specimen adds to a growing assemblage of Chinese Jurassic non-sauropodan sauropodomorphs that offers new insight into the Laurasian evolution of this clade.
Ontogenetic trophic segregation between two threatened smooth-hound sharks in the Central Mediterranean Sea
Authors: Di Lorenzo Manfredi , Vizzini Salvatrice , Signa Geraldina , Andolina Cristina , Boscolo Palo Gabriele , Gristina Michele , Mazzoldi Carlotta , Colloca Francesco 
Published: July 2020

AbstractElasmobranchs are among the species most threatened by overfishing and a large body of evidence reports their decline around the world. As they are large predators occupying the highest levels of marine food webs, their removal can alter the trophic web dynamic through predatory release effects and trophic cascade. Suitable management of threatened shark species requires a good understanding of their behaviour and feeding ecology. In this study we provide one of the first assessments of the trophic ecology of the “vulnerable” smooth-houndsMustelus mustelusandM. punctulatusin the Central Mediterranean Sea, based on stomach contents and stable isotope analyses. Ontogenetic diet changes were addressed by comparing the feeding habits of three groups of individuals: juveniles, maturing and adults. Our results highlighted that the two species share a similar diet based mostly on the consumption of benthic crustaceans (e.g. hermit crabs). Their trophic level increases during ontogeny, with adults increasing their consumption of large-sized crustaceans (e.g.Calappa granulata,Palinurus elephas), cephalopods (e.g.Octopus vulgaris) and fish (e.g.Trachurus trachurus). Our results provide also evidence of ontogenetic shifts in diet for both species showing a progressive reduction of interspecific trophic overlap during growth. The results of this study contribute to improve the current knowledge on the trophic ecology of these two threatened sharks in the Strait of Sicily, thus providing a better understanding of their role in the food web.
Analysis and observation of the breakdown of Babinet’s principle in complementary spoof surface plasmon polariton structures
Authors: Itami Go , Sakai Osamu 
Published: July 2020

AbstractA metal plate array (MPA) which is a structure complimentary to a metal hole array (MHA), supports spoof surface plasmon polaritons (SSPP) as well as an MHA does. Babinet’s principle attributes the phenomenon of duality to transmission characteristics of the complimentary impedance surfaces because of the symmetry of the behaviors of electric and magnetic fields. However, it is also a fact that the complimentary structures do not follow this principle if they have wavelength-size thickness, because electromagnetic waves do not treat such thick structures as a boundary surface but as propagation spaces with the specific boundaries such as a waveguide which shows SSPP modes. If the thickness is so small that it is negligible, Babinet’s principle is still valid, while it has been uncertain how the layer thickness works to break the principle as it is increased. The unconfirmed transformation is revealed analytically and experimentally with the use of MPAs and MHAs of varying thicknesses.
Circulating proteomic signature for detection of biomarkers in bladder cancer patients
Authors: Nedjadi Taoufik , Benabdelkamal Hicham , Albarakati Nada , Masood Afshan , Al-Sayyad Ahmed , Alfadda Assim A. , Alanazi Ibrahim O. , Al-Ammari Adel , Al-Maghrabi Jaudah 
Published: July 2020

AbstractThe identification of clinically-relevant early diagnostic and prognostic protein biomarkers is essential to maximize therapeutic efficacy and prevent cancer progression. The aim of the current study is to determine whether aberrant plasma protein profile can be applied as a surrogate tool for early diagnosis of bladder carcinoma. Plasma samples from patients with low grade non-muscle invasive bladder cancer and healthy controls were analyzed using combined 2D-DIGE and mass-spectrometry to identify differentially expressed proteins. Validation was performed using western blotting analysis in an independent cohort of cancer patients and controls. Fifteen differentially-expressed proteins were identified of which 12 were significantly up-regulated and three were significantly down-regulated in tumors compared to controls. The Ingenuity Pathways Analysis revealed functional connection between the differentially-expressed proteins and immunological disease, inflammatory disease and cancer mediated through chemokine and cytokine signaling pathway and NF-kB transcription factor. Among the three validated proteins, haptoglobin was able to distinguish between patients with low grade bladder cancer and the controls with high sensitivity and specificity (AUC > 0.87). In conclusion, several biomarker proteins were identified in bladder cancer. Haptoglobin is a potential candidate that merit further investigation to validate its usefulness and functional significance as potential biomarkers for early detection of bladder cancer.
PARGT: a software tool for predicting antimicrobial resistance in bacteria
Authors: Chowdhury Abu Sayed , Call Douglas R. , Broschat Shira L. 
Published: July 2020

AbstractWith the ever-increasing availability of whole-genome sequences, machine-learning approaches can be used as an alternative to traditional alignment-based methods for identifying new antimicrobial-resistance genes. Such approaches are especially helpful when pathogens cannot be cultured in the lab. In previous work, we proposed a game-theory-based feature evaluation algorithm. When using the protein characteristics identified by this algorithm, called ‘features’ in machine learning, our model accurately identified antimicrobial resistance (AMR) genes in Gram-negative bacteria. Here we extend our study to Gram-positive bacteria showing that coupling game-theory-identified features with machine learning achieved classification accuracies between 87% and 90% for genes encoding resistance to the antibiotics bacitracin and vancomycin. Importantly, we present a standalone software tool that implements the game-theory algorithm and machine-learning model used in these studies.
Dietary administration of the probiotic Shewanella putrefaciens to experimentally wounded gilthead seabream (Sparus aurata L.) facilitates the skin wound healing
Authors: Chen Zhichu , Ceballos-Francisco Diana , Guardiola Francisco A. , Esteban M. Ángeles 
Published: July 2020

AbstractThe effect of the probiotic Shewanella putrefaciens Pdp11 (SpPdp11) was studied on the skin healing of experimentally wounded gilthead seabream (Sparus aurata L.). Two replicates (n = 12) of fish were fed CON diet or SP diet for 30 days. Half of the fish were sampled while the others were injured and sampled 7 days post-wounding. Results by image analysis of wound areas showed that SpPdp11 inclusion facilitated wound closure. Compared with the CON group, fish in SP group sampled 7 days post-wounding had a significantly decreased serum AST and increased ALB/GLOB ratio. Furthermore, protease and peroxidase activities were significantly increased in skin mucus from fish in SP group sampled 7 days post-wounding, compared with those fed CON diet. Additionally, SP diet up-regulated the gene expression of antioxidant enzymes, anti-inflammatory cytokines, and re-epithelialization related genes in the fish skin. Furthermore, significant decreases in pro-inflammatory cytokines expression were detected in fish from SP group, respect to control ones. Overall, SpPdp11 inclusion facilitated the wound healing and the re-epithelialization of the damaged skin, alleviated the inflammatory response in the wound area through intensifying the antioxidant system, and enhancing the neo-vascularization and the synthesis of matrix proteins in the skin wound sites of fish.
Study on improvement of the performance parameters of a novel 0.41–0.47 THz on-chip antenna based on metasurface concept realized on 50 μm GaAs-layer
Authors: Alibakhshikenari Mohammad , Virdee Bal S. , See Chan H. , Shukla Pancham , Salekzamankhani Shahram , Abd-Alhameed Raed A. , Falcone Francisco , Limiti Ernesto 
Published: July 2020

AbstractA feasibility study is presented on the performance parameters of a novel on-chip antenna based on metasurface technology at terahertz band. The proposed metasurface on-chip antenna is constructed on an electrically thin high-permittivity gallium arsenide (GaAs) substrate layer. Metasurface is implemented by engraving slot-lines on an array of 11 × 11 circular patches fabricated on the top layer of the GaAs substrate and metallic via-holes implemented in the central patch of each row constituting the array, which connects the patch to the leaky-wave open-ended feeding slot-lines running underneath the patches. The slot-lines are connected to each other with a slit. A waveguide port is used to excite the array via slot-lines that couple the electromagnetic energy to the patches. The metasurface on-chip antenna is shown to exhibit an average measured gain in excess of 10 dBi and radiation efficiency above 60% over a wide frequency range from 0.41 to 0.47 THz, which is significant development over other on-chip antenna techniques reported to date. Dimensions of the antenna are 8.6 × 8.6 × 0.0503 mm3. The results show that the proposed GaAs-based metasurface on-chip antenna is viable for applications in terahertz integrated circuits.
Spatio-molecular domains identified in the mouse subthalamic nucleus and neighboring glutamatergic and GABAergic brain structures
Authors: Wallén-Mackenzie Åsa , Dumas Sylvie , Papathanou Maria , Martis Thiele Mihaela M. , Vlcek Bianca , König Niclas , Björklund Åsa K. 
Published: July 2020

AbstractThe subthalamic nucleus (STN) is crucial for normal motor, limbic and associative function. STN dysregulation is correlated with several brain disorders, including Parkinsonʼs disease and obsessive compulsive disorder (OCD), for which high-frequency stimulation of the STN is increasing as therapy. However, clinical progress is hampered by poor knowledge of the anatomical–functional organization of the STN. Today, experimental mouse genetics provides outstanding capacity for functional decoding, provided selective promoters are available. Here, we implemented single-nuclei RNA sequencing (snRNASeq) of the mouse STN followed through with histological analysis of 16 candidate genes of interest. Our results demonstrate that the mouse STN is composed of at least four spatio-molecularly defined domains, each distinguished by defined sets of promoter activities. Further, molecular profiles dissociate the STN from the adjoining para-STN (PSTN) and neighboring structures of the hypothalamus, mammillary nuclei and zona incerta. Enhanced knowledge of STN´s internal organization should prove useful towards genetics-based functional decoding of this clinically relevant brain structure.
DNA methylation reprogramming during seed development and its functional relevance in seed size/weight determination in chickpea
Authors: Rajkumar Mohan Singh , Gupta Khushboo , Khemka Niraj Kumar , Garg Rohini , Jain Mukesh 
Published: July 2020

AbstractSeed development is orchestrated via complex gene regulatory networks and pathways. Epigenetic factors may also govern seed development and seed size/weight. Here, we analyzed DNA methylation in a large-seeded chickpea cultivar (JGK 3) during seed development stages. Progressive gain of CHH context DNA methylation in transposable elements (TEs) and higher frequency of small RNAs in hypermethylated TEs during seed development suggested a role of the RNA-dependent DNA methylation pathway. Frequency of intragenic TEs was higher in CHH context differentially methylated region (DMR) associated differentially expressed genes (DEGs). CG context hyper/hypomethylation within the gene body was observed for most of DMR-associated DEGs in JGK 3 as compared to small-seeded chickpea cultivar (Himchana 1). We identified candidate genes involved in seed size/weight determination exhibiting CG context hypermethylation within the gene body and higher expression in JGK 3. This study provides insights into the role of DNA methylation in seed development and seed size/weight determination in chickpea.