bluuebunny/crossref_metadata_2025_split huggingface dataset:
LabSafety, the Pharmaceutical Laboratory Android Application, for Improving the Knowledge of Pharmacy Students
Authors: Ameri Arefeh , Khajouei Reza , Ameri Alieh , Jahani Yunes 
Published: October 2019

AbstractCurrently, traditional paper methods may not effectively be used in education due to lack of access, outdated content, and poor graphics. Education through mobile‐based applications is one of the alternative solutions. The objective of this study was to develop and evaluate LabSafety educational application and its effect on promoting the knowledge of pharmacy students. In this interventional study, the LabSafety application was first developed and evaluated for educating students about the safety measures in laboratories. Then, all pharmacy students from Kerman University of Medical Sciences (n = 316) were selected and randomly enrolled into one of three groups using simple random sampling: control (n = 106), traditional (n = 105), and application (n = 105) groups. To assess students' knowledge before and after the intervention, two valid and reliable (Cronbach's Alpha = 0.94 and 0.93, respectively) questionnaires were used. The results of the study showed no significant differences among the mean scores of the participants' knowledge before intervention (p = 0.82). After the intervention, the mean scores of the application group were 5.52 higher than the scores of the traditional group and 7.3 higher than the scores of the control group (p < 0.0001). Age had no significant effect on the posttest scores of the participants (p = 0.52). As a result, the use of this educational application can effectively increase the knowledge of all age groups of pharmacy students regarding safety measures in pharmaceutical laboratories. The mobile‐based applications with online and offline access, interactive features, and user‐friendly interfaces are more engaging and they can be used complementary to traditional training methods. © 2019 International Union of Biochemistry and Molecular Biology, 48(1):44–53, 2020.
Sinus Floor Augmentation in Presence of Mucocele Eroding Maxillary Sinus Wall: A Case Report With 3 Years Follow‐Up
Authors: Medikeri Raghavendra S. , Sinha Kumar Ankit 
Published: October 2019

IntroductionThe maxillary mucocele is a slow‐growing aggressive lesion and a mucous‐containing sac lined with epithelium that occurs due to ductal obstruction and self‐limiting injury. Rarely, it may be associated with non‐specific symptoms. It is characterized by bone resorption due to its expanding behavior. Reduced height of bone and sinus pneumatization associated with pathologic lesions located in the floor of maxillary sinus may impede sinus augmentation. Therefore, careful diagnosis and management of pathology before sinus floor elevation is important in determining its recurrence and prognosis.Case PresentationWe reported a case with small mucocele on right pneumatized antrum with insufficient residual bone height for implant placement. Radiograph in the region of teeth #3 and #4 revealed a homogeneous solitary radiopaque mass. Cone‐beam computed tomography revealed irregular osteolysis of the lateral wall of the sinus. It was excised through Caldwell‐Luc technique and simultaneous sinus augmentation was performed. Later, delayed implant restoration was performed. No complication or recurrence was reported during 36 months of follow‐up.ConclusionsThe excision of mucocele on sinus floor and simultaneous sinus augmentation obviates the need for the extended treatment period. The clinician must be habituated with the anatomy and pathology of the maxillary sinus to evade any non‐essential complications following lateral sinus floor augmentation procedure. A diminutive mucocele should not be regarded as a contraindication for sinus augmentation; sometimes it manifests with bone erosion. The prompt diagnosis and careful evaluation are needed to avoid future complications during implant therapy.
Dissected saccular aneurysms of the ascending aorta
Authors: Aljasem Hazem , Izzat Mohammad Bashar 
Published: October 2019

AbstractThis report highlights the need for distinction between saccular and fusiform aortic aneurysms, considering the high risk of rupture of saccular aneurysms. The management of dissected saccular aneurysms involves elective replacement of the dissected aorta while preserving the aortic valve.
Electrocatalytically Active Silver Organic Framework: Ag(I)‐Complex Incorporated in Activated Carbon
Authors: Gonen Shmuel , Lori Oran , Fleker Ohad , Elbaz Lior 
Published: October 2019

AbstractSilver is known as a viable alternative for platinum group metals for the catalysis of the oxygen reduction reaction in alkaline electrolyte. Unlike most other platinum‐group metal‐free catalysts, usually organo‐metallic complexes, silver is commonly used in its metallic form (Ag(0)). Herein, we describe the preparation, characterization, and electrochemical activity of a unique silver‐based catalyst, based on Ag(I) ions coordinated to oxygen groups in an organic ligand (benzene tricarboxylic acid ‐ BTC) which forms a metal organic framework, similar to first‐row transition metal‐based catalysts in metal organic frameworks. When the silver‐based catalyst is incorporated in a porous carbon support, it exhibits high electrocatalytic activity for the oxygen reduction reaction, with a distinct electrochemical behavior, different than metallic silver. In addition, the use of the ionic form of the silver, which is atomically dispersed, allows to lower its loading of the metal by at least one order of magnitude when compared to other reported silver‐based oxygen reduction reaction catalysts.
Coalescence Characteristics of Side‐by‐Side Growing Bubbles in Carboxymethyl Cellulose Solutions
Authors: Fan Wenyuan , Du Mengqi , Sun Yawei , Chen Hui 
Published: October 2019

AbstractNew experimental data are presented on the coalescence dynamics of twin bubbles at two adjacent nozzles in carboxymethyl cellulose (CMC) solutions. The coalescence process was recorded by using a fast video technique and the images were then analyzed to evaluate the regime, efficiency, and patterns of bubble coalescence. The results reveal that the coalescence process contains the four periods of spherical expansion, rapid mergence, overall growth, and instant departure. The coalescence efficiency always passes through five stages with the gas flow rate; it grows with the CMC solution concentration, but decreases with the surfactant concentration, except at very low gas flow rates. The bubble coalescence pattern strongly depends on the nozzle spacing, but conditionally on the gas flow rate and the solution properties.
Unconventional Reactivity of Ethynylbenziodoxolone Reagents and Thiols: Scope and Mechanism
Authors: Liu Bin , Alegre‐Requena Juan V. , Paton Robert S. , Miyake Garret M. 
Published: October 2019

Abstract1,2‐Dithio‐1‐alkenes are biologically active compounds widely implemented throughout organic synthesis, functional materials, coordination chemistry, and pharmaceuticals. Traditional methods for accessing 1,2‐dithio‐1‐alkenes often demand transition metal catalysts, specialized or air‐sensitive ligands, high temperatures, and disulfides (R2S2). Herein, a general and efficient strategy utilizing ethynylbenziodoxolone (EBX) reagents and thiols is presented that results in the formation of 1,2‐dithio‐1‐alkenes with excellent regioselectivity and stereoselectivity through unprecedented reactivity between the EBX and the thiol. This operationally simple procedure utilizes mild conditions, which result in a broad substrate scope and high functional‐group tolerance. The observed unexpected reactivity has been rationalized through both experimental results and DFT calculations.
Leverage side information for top‐N recommendation with latent Gaussian process
Authors: Zhou Wang , Li Jianping , Yang Yujun , Shah Fadia 
Published: October 2019

SummaryCurrently, Recommender Systems (RS) have been ubiquitously applied to various online applications and obtained tremendous success due to their capability to overcome information overload; however, the available Side Information (SI), such as demographics and attributions of items, is always neglected. Actually, SI could reflect user's interests and preference, and even influence user's decision over items; therefore, it would be greatly helpful to leverage side information to improve the performance of RS, which is already partly certificated in previous research studies. Motivated by this, in this article, a novel multi‐task learning‐based recommendation system referred to as LGP‐RS is proposed, which takes utility functions mapping from the non‐linear side information to low‐rank feature space with Gaussian process (GP) priors, for users and items, respectively. In addition, Laplace approximation method is employed to approximate the posterior distribution for the utility functions, and gradient‐based method is employed to learn the hyperparameters for GP. This flexible approach is able to capture the non‐linear high‐order interactions within side information, reduce the prediction uncertainty, and provide personalized top‐N recommendation. Experimental analysis over three real‐world datasets demonstrates that LGP‐RS could deal with both explicit and implicit side information simultaneously, and significantly outperforms state‐of‐the‐art approaches.
Generation of Functional CX26–Gap‐Junction‐Plaque‐Forming Cells with Spontaneous Ca2+ Transients via a Gap Junction Characteristic of Developing Cochlea
Authors: Fukunaga Ichiro , Fujimoto Ayumi , Hatakeyama Kaori , Kurebayashi Nagomi , Ikeda Katsuhisa , Kamiya Kazusaku 
Published: October 2019

AbstractMutation of the gene GJB2, encoding connexin 26 (CX26; also known as gap junction beta 2), is the most frequent cause of hereditary deafness worldwide. CX26 is expressed in cochlear nonsensory cells, such as cochlear supporting cells, and forms gap junction plaques (GJPs) at cell‐cell borders. Cochlear CX26‐GJP‐forming cells (Cx26GJCs) are thought to be an important therapeutic target for treatment of hereditary deafness. Nevertheless, the generation of Cx26GJCs—such as cochlear supporting cells—from embryonic stem/induced pluripotent stem (ES/iPS) cells has not been reported to date. Here, we detail a novel strategy for differentiating iPS cells into functional Cx26GJCs such as are found in cochlea. Several assays to characterize the phenotype of iPS‐derived Cx26GJCs are described, including qRT‐PCR, immunohistological analysis, morphological analysis, a scrape‐loading and dye transfer assay, and calcium imaging. This in vitro model has applications in the establishment of inner‐ear cell therapies and in drug screening to target GJB2‐related hearing loss. © 2019 by John Wiley & Sons, Inc.Basic Protocol: Induction of mouse stem cells to create CX26‐GJP‐forming cellsSupport Protocol 1: Maintenance and passage of mouse induced pluripotent stem cellsSupport Protocol 2: Screening for high GJB2 and GJB6 expression in SFEBq culture using quantitative real‐time PCRSupport Protocol 3: Characterization of cells at different stages of differentiation by immunostainingSupport Protocol 4: Ultrastructural analyses of cells at different stages of CX26‐GJP‐forming cell inductionSupport Protocol 5: Functional analyses of stem cell–derived CX26‐GJP‐forming cells
Live Cell Monitoring and Enrichment of Stem Cell‐Derived β Cells Using Intracellular Zinc Content as a Population Marker
Authors: Davis Jeffrey C. , Helman Aharon , Rivera‐Feliciano José , Langston Christine M. , Engquist Elise N. , Melton Douglas A. 
Published: October 2019

AbstractOur laboratory and others have developed protocols to generate glucose‐responsive stem cell–derived β cells in vitro. The cells resulting from these protocols could supplement or replace the use of human cadaveric islets for cell‐based therapy for diabetes. The combination of an unlimited supply of pluripotent stem cell–derived β cells and gene‐editing approaches will facilitate numerous in vitro studies not possible with cadaveric islets. Here, we describe a protocol for fluorescent labeling and isolation of stem cell–derived β cells. This purification of SC‐β cells is based on intracellular zinc content and is a simple method to complement other approaches for generating and assaying these cells. © 2019 The Authors.Basic Protocol: Fluorescent labeling and isolation of stem cell‐derived β cells
Enhancing tristetraprolin activity reduces the severity of cigarette smoke‐induced experimental chronic obstructive pulmonary disease
Authors: Nair Prema M , Starkey Malcolm R , Haw Tatt Jhong , Liu Gang , Collison Adam M , Mattes Joerg , Wark Peter A. , Morris Jonathan C , Verrills Nikki M , Clark Andrew R , Ammit Alaina J , Hansbro Philip M 
Published: October 2019

AbstractObjectiveChronic obstructive pulmonary disease (COPD) is a progressive disease that causes significant mortality and morbidity worldwide and is primarily caused by the inhalation of cigarette smoke (CS). Lack of effective treatments for COPD means there is an urgent need to identify new therapeutic strategies for the underlying mechanisms of pathogenesis. Tristetraprolin (TTP) encoded by the Zfp36 gene is an anti‐inflammatory protein that induces mRNA decay, especially of transcripts encoding inflammatory cytokines, including those implicated in COPD.MethodsHere, we identify a novel protective role for TTP in CS‐induced experimental COPD using Zfp36aa/aa mice, a genetically modified mouse strain in which endogenous TTP cannot be phosphorylated, rendering it constitutively active as an mRNA‐destabilising factor. TTP wild‐type (Zfp36+/+) and Zfp36aa/aa active C57BL/6J mice were exposed to CS for four days or eight weeks, and the impact on acute inflammatory responses or chronic features of COPD, respectively, was assessed.ResultsAfter four days of CS exposure, Zfp36aa/aa mice had reduced numbers of airway neutrophils and lymphocytes and mRNA expression levels of cytokines compared to wild‐type controls. After eight weeks, Zfp36aa/aa mice had reduced pulmonary inflammation, airway remodelling and emphysema‐like alveolar enlargement, and lung function was improved. We then used pharmacological treatments in vivo (protein phosphatase 2A activator, AAL(S), and the proteasome inhibitor, bortezomib) to promote the activation and stabilisation of TTP and show that hallmark features of CS‐induced experimental COPD were ameliorated.ConclusionCollectively, our study provides the first evidence for the therapeutic potential of inducing TTP as a treatment for COPD.
Experimental harvest regulations reveal that water availability during spring, not harvest, affects change in a waterfowl population
Authors: Sedinger Benjamin S. , Riecke Thomas V. , Nicolai Christopher A. , Woolstenhulme Russell , Henry William G. , Stewart Kelley M. 
Published: October 2019

AbstractPopulation change is regulated by vital rates that are influenced by environmental conditions, demographic stochasticity, and, increasingly, anthropogenic effects. Habitat destruction and climate change threaten the future of many wildlife populations, and there are additional concerns regarding the effects of harvest rates on demographic components of harvested organisms. Further, many population managers strictly manage harvest of wild organisms to mediate population trends of these populations. The goal of our study was to decouple harvest and environmental variability in a closely monitored population of wild ducks in North America, where we experimentally regulated harvest independently of environmental variation over a period of 4 years. We used 9 years of capture–mark–recapture data to estimate breeding population size during the spring for a population of wood ducks in Nevada. We then assessed the effect of one environmental variable and harvest pressure on annual changes in the breeding population size. Climatic conditions influencing water availability were strongly positively related to population growth rates of wood ducks in our study system. In contrast, harvest regulations and harvest rates did not affect population growth rates. We suggest efforts to conserve waterfowl should focus on the effects of habitat loss in breeding areas and climate change, which will likely affect precipitation regimes in the future. We demonstrate the utility of capture–mark–recapture methods to estimate abundance of species which are difficult to survey and test the impacts of anthropogenic harvest and climate on populations. Finally, our results continue to add to the importance of experimentation in applied conservation biology, where we believe that continued experiments on nonthreatened species will be critically important as researchers attempt to understand how to quantify and mitigate direct anthropogenic impacts in a changing world.
Open access efforts begin to bloom: ESC Heart Failure gets full attention and first impact factor
Authors: Anker Stefan D. , von Haehling Stephan , Papp Zoltan 
Published: October 2019

AbstractIn 2014, the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) founded the first open access journal focusing on heart failure, called ESC Heart Failure (ESC‐HF). In the first 5 years, in ESC‐HF we published more than 450 articles. Through ESC‐HF, the HFA gives room for heart failure research output from around the world. A transfer process from the European Journal of Heart Failure to ESC‐HF has also been installed. As a consequence, in 2018 ESC‐HF received 289 submissions, and published 148 items (acceptance rate 51%). The journal is listed in Scopus since 2014 and on the PubMed website since 2015. In 2019, we received our first impact factor from ISI Web of Knowledge / Thomson‐Reuters, which is 3.407 for 2018. This report reviews which papers get best cited. Not surprisingly, many of the best cited papers are reviews and facts & numbers mini reviews, but original research is also well cited.
Oxidative decarboxylation of 2‐oxoacids by hydroperoxides can be used to lower peroxide values in citrus oils
Authors: Calandra Michael J. , Wang Ying 
Published: October 2019

AbstractMany terpenes may autoxidize under certain conditions to form terpene hydroperoxides, which have been reported to be skin sensitizers that may cause allergic contact dermatitis. The fragrance industry is currently required to monitor terpene hydroperoxide levels in many raw materials by iodometric titration (aka; the peroxide value, or POV test), and to reject lots that exceed a specification limit. We have found that compounds containing the 2‐oxoacid moiety (the “pyruvic acid” moiety) react readily with organic hydroperoxides via an oxidative decarboxylation mechanism. The reaction products include an alcohol corresponding to the reduced hydroperoxide, carbon dioxide, and a carboxylic acid that is one carbon shorter than the starting 2‐oxoacid. Because the hydroperoxide is irreversibly consumed by this reaction, the POV of a 2‐oxoacid‐treated sample is effectively lowered. It follows that the skin sensitizing potential of the treated sample should also be lowered as a result of the hydroperoxide removal.
Evaluation of nutritional profile and total antioxidant capacity of the Mediterranean diet of southern Spain
Authors: González Carmen Maria , Martínez Lorena , Ros Gaspar , Nieto Gema 
Published: October 2019

AbstractThe objective of this study was to determine the antioxidant capacity of a Mediterranean diet consisting typical dishes from southern Spain. For that, a 5‐day diet was developed with typical dishes of Murcia. The antioxidant capacity of the diet was measured using ORACHF, FRAP, and DPPH methods, and the total phenolic compound content of this diet was estimated by Folin–Ciocalteu. About 50% of the antioxidant capacity and 29% of the phenolic compounds per day came from sample 14 (artichokes with ham), whereas only 1% and a 4%, respectively, proceed from sample 16 (gypsy pot). The total antioxidant capacity of the diet was estimated as 9,506.33 ET/100 g/person/day by the ORACHF method, and the total phenolic consume was estimated as 1,839.05 mg GAE/person/day. The proposed diet can be considered an excellent strategy for improving the nutritional status of the population because of its high antioxidant activity and phenolic compound content.
Source rock composition of Kaimur Group siliciclastics from Vindhyan Supergroup, Central India: A response to thermal events associated with Bundelkhand Craton and Chhotanagpur Gneissic Complex at ~1.1 Ga
Authors: Sen Shinjana , Mishra Meenal 
Published: October 2019

The Kaimur Group of the Vindhyan Supergroup has been divided into six Formations in Son valley sector, in Central part of India, i.e., Sasaram Sandstone, Ghurma Shale, Markundi Sandstone, Bijaigarh Shale, Mangesar Formation, and Dhandraul Sandstone. The comprehensive geochemical datasets for all the individual Formations of the Kaimur Group were generated in order to evaluate the source rock composition, weathering history, and provenance. The field observations, petrography, and geochemistry depict the deposition of the Kaimur sedimentary rocks in two cycles—the fining‐upward sequence from Sasaram to Markundi Sandstone, that was followed by the coarsening‐upward sequence from Bijaigarh shale to Dhandraul Sandstone. The petrography, geochemical classification, and A‐CN‐K plot depicts K‐metasomatism in siliciclastics of Kaimur Group. A‐CN‐K systematics and the CIA values (62–85) reveal that the source rocks of the Kaimur Group siliciclastics have suffered high degrees of chemical weathering under warm and humid climate. Zr/Sc vs. Th/Sc and Rb/Sr values depict zircon addition and sediment recycling. Ternary plots based on modal analysis and tectonic discrimination diagrams based on incompatible elements exhibit the deposition of Kaimur siliciclastics in the craton interior /passive margin (Bundelkhand Craton; BC) to recycled orogen (Chhotanagpur Gneissic Complex;CGC). The incompatible elemental ratios and Qm‐F‐Lt plots shows a fluctuation in provenance of the Kaimur Formations in the lower and upper part. The percentage contribution from the two sources was calculated using a simple arithmetic formulae [ Percentage contibution from a single source= Number of comparable ratios/ Total ratios*100]: Sasaram Sandstone = 82% BC + 18% CGC, Ghurma Shale = 76% BC + 24% CGC, Markundi Sandstone = 65% BC + 35% CGC, Bijaigarh Shale = 62% BC + 38% CGC, Mangesar Formation = 61% BC + 39% CGC, and Dhandraul Sandstone = 42% BC + 58% CGC. Tectonics of the hinterland supplying detritus played an important role in deciphering the provenance of Kaimur siliciclastics. The episodic crustal growth and thermal events taking place in Bundelkhand Craton at 1.1 Ga were witnessed by the emplacement of dykes, which led to the increased detrital input from the source (BC). Later on the upliftment of CGC towards the south during Satpura Orogeny‐II led to increase in input to the Formations of Kaimur Group. Petrological, geochemical signatures, and the evidences of change in paleocurrent direction from SSE–SSW to NW–NNW during Kaimur sedimentation strongly support the gradual shift of provenance from BC to CGC.