bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticoagulation Management for Impella Percutaneous Ventricular Assist Devices: An Analysis of a Single-Center Experience
Authors: Wood Ethan , Hayes Charles , Hart Anthony 
Published: May 2020

Background: Impella devices offer temporary mechanical circulatory support for cardiogenic shock. The manufacturer recommends systemic anticoagulation with a target activated clotting time of 160 to 180 s but provides no guidance on how to manage both the heparinized purge solution and the additional intravenous heparin needed to reach this therapeutic range. Previous publications demonstrated a lack of standardization in heparin management for Impella devices. Objective: The purpose of this study was to compare the effectiveness and safety of 2 different heparin protocols for long-term Impella support. Methods: This single-center, retrospective study included adult patients on Impella support for greater than 24 hours. The primary end point was time to therapeutic range measured in hours, from time of implantation to the first of 2 consecutive measurements within the therapeutic range. Secondary end points included percentage of time in therapeutic range, rates of major bleeding, pump thrombosis, hemolysis, and nursing satisfaction. Results: There were 19 patients identified, with 7 using the original protocol and 12 using the revised protocol. Time to therapeutic range was similar between protocols (15.5 vs 12 hours, P = NS). Another 14 patients were managed with patient-specific protocols as a result of bleeding or physician preference. In total, 42% of all patients in this study experienced major bleeding. There were no confirmed thrombosis events. This study was limited by a small sample size. Conclusion and Relevance: Despite using different heparin protocols, outcomes and bleeding events were similar between groups. Future studies are needed to determine the optimal degree of anticoagulation necessary to reduce bleeding risk.
Waterproof cast liners for pediatric forearm fractures – A comparison of two products
Authors: Trivellas Myra , Hennrikus William , Gupta Rahul , Slough Jennifer , Armstrong Douglas , Piazza Brian , Wieler Jane 
Published: May 2020

Introduction Waterproof lining in casting in the pediatric population is becoming more commonplace due to the improved quality of life for the child by providing patients with a higher physical functional level when compared to those with non-waterproof lining. The objective of this study is to compare patient satisfaction and outcomes of two commonly used waterproof liners. Methods A prospective, randomized-controlled trial of children with stable forearm fractures not requiring reduction was conducted. Of those who chose a waterproof lining, patients were randomized to one of two products: Delta Dry® or Aquacast®. At the time of cast removal, each patient and medical assistant who applied and removed the cast completed surveys about their satisfaction with the cast. A two-sample T-test for independent samples was used to compare the two cast liners. Results Both liners were well liked by patients with no statistically significant difference in satisfaction scores nor were there differences in water exposure between the two groups (pool use, showering, or lake swimming). The medical assistants scored Aquacast® higher in three out of four domains but again there was no statistical difference. There were no fracture complications nor problems from cast application or removal. Conclusion Both waterproof cast liners were safe and efficacious. No significant differences were detected in any measured parameter including overall high patient satisfaction.
Six-month results of stenting of the femoropopliteal artery and predictive value of interleukin-6: Comparison with high-sensitivity C-reactive protein
Authors: Guo Songlin , Zhang Zhang , Wang Lei , Yuan Liangxi , Bao Junmin , Zhou Jian , Jing Zaiping 
Published: May 2020

Objectives To determine the association of pre- and postinterventional serum levels of interleukin-6 and high-sensitivity C-reactive protein at the six-month evaluation of restenosis after stenting of the femoropopliteal artery. Methods Sixty-eight consecutive patients with steno-occlusive femoropopliteal artery disease of Rutherford category III or IV who underwent stent implantation were included. Six-month patency was evaluated with color-coded duplex ultrasound. The association of in-stent restenosis with interleukin-6 and high-sensitivity C-reactive protein levels at baseline, and 24-h postintervention was assessed with a multivariate logistic regression analysis. Results In-stent restenosis was found in 15 patients (22.1%) within six months. Interleukin-6 and high-sensitivity C-reactive protein levels were significantly increased at 24-h postintervention compared to their preintervention values ( p < 0.001 and p = 0.002, respectively). Interleukin-6 values at baseline (odds ratio, 1.11; 95% confidence interval: 1.00, 1.23; p = 0.044) and 24-h postintervention (odds ratio, 1.04; 95% confidence interval: 1.02, 1.06; p < 0.001) were independently associated with six-month in-stent restenosis. Twenty-four-hour postinterventional high-sensitivity C-reactive protein levels were also found to be related to restenosis (odds ratio, 1.15; 95% confidence interval: 1.04, 1.26; p = 0.006), but high-sensitivity C-reactive protein levels at baseline did not show an independent association with in-stent restenosis (odds ratio, 0.57; 95% confidence interval: 0.35, 1.80; p = 0.667). Smoking, diabetes mellitus, and cumulative stent length were other parameters associated with an increased risk for in-stent restenosis. Conclusions Femoropopliteal artery angioplasty with stent placement induces an inflammatory response. Interleukin-6 is a powerful independent predictor of intermediate-term outcomes for stenting of the femoropopliteal artery, suggesting that its predictive value may be superior to that of high-sensitivity C-reactive protein.
Effect of carvedilol on arteriovenous graft primary patency
Authors: Tseng Yuan-Hsi , Liu Chia-Yen , Lee Chuan-Pin , Lin Meng-Hung , Yang Yao-Hsu 
Published: May 2020

Background The major mechanisms of arteriovenous graft (AVG) failure due to intimal hyperplasia (IH) are smooth muscle cell proliferation and inflammation. Therefore, carvedilol may improve AVG primary patency because of its anti-proliferative and anti-inflammatory activities. Methods The data of end-stage renal disease patients receiving regular hemodialysis were collected from the National Health Insurance Research database. The end point was the first percutaneous transluminal angioplasty (PTA) for AVG failure or death during a follow-up period of two years or the end of 2013. The analysis was calculated with Cox proportional hazard model. Results There were 3028 patients treated with carvedilol and 13,704 patients not treated with carvedilol. According to a univariate analysis, the carvedilol group was younger, received more anti-hypertensive medications and platelet aggregation inhibitors, and had higher rates of diabetes mellitus and hyperlipidemia but had lower rates of hypotension and smoking. According to a multivariate analysis, after controlling for covariates, the use of carvedilol for more than 84 days reduced the probability of a first PTA for AVG failure by 9% compared with no use of carvedilol ( p = 0.021), but the use of carvedilol for 1 to 84 days did not. Conclusion The results of this study indicate that the use of carvedilol for more than 84 days improves the primary patency of AVGs, but the use of carvedilol for less than 84 days does not.
Long-term outcomes of monascin – a novel dual peroxisome proliferator-activated receptor γ/nuclear factor-erythroid 2 related factor-2 agonist in experimental intracerebral hemorrhage
Authors: Fu Pengcheng , Liu Jiachen , Bai Qinqin , Sun Xingang , Yao Zhenjia , Liu Lirong , Wu Cuimei , Wang Gaiqing 
Published: May 2020

Background: Hematoma is the chief culprit in brain injury following intracranial cerebral hemorrhage (ICH). Noninvasive hematoma clearance could be an option to prevent and alleviate early brain injury after ICH. Peroxisome proliferator-activated receptor γ (PPAR-γ) and nuclear factor-erythroid 2 related factor-2 (Nrf2) facilitate removal of hematoma in ICH. Monascin acts as the natural Nrf2 activator with PPAR-γ agonist, and the long-term effects of monascin following ICH have not been elucidated. Methods: ICH in rats was induced by stereotactic, intrastriatal injection of type IV collagenase. Monascin was administered twice daily by gastric perfusion for 14 days after ICH induction. Long-term neurological scores (T maze, Garcia scales, rotor rod test, and Morris water maze), hematoma volume, as well as iron overload around hematoma and brain atrophy were evaluated at 7, 14, and 28 days after ICH. Results: The results showed that monascin improved long-term neurological deficits, spatial memory performance, learning ability, and brain shrinkage after ICH. Monascin also reduced hematoma volume at 7 days and iron content at 7 and 14 days after ICH. Conclusion: PPAR γ and Nrf2 play a crucial role in hematoma clearance after ICH in rat. As a dual agonist of PPAR γ and Nrf2, monascin improved long-term outcomes by facilitating hematoma clearance, and by attenuating iron overload and brain atrophy after experimental ICH.
Service user and staff acceptance of fetal ultrasound telemedicine
Authors: Bidmead Elaine , Lie Mabel , Marshall Alison , Robson Stephen , Smith Vikki J. 
Published: May 2020

Objective We present qualitative findings from interviews with frontline clinicians and service users of a fetal telemedicine service. Methods Semi-structured interviews with clinical stakeholders and service users were conducted, undertaken as part of a service evaluation. Data collection was undertaken by different teams, using interview schedules aligned to independent evaluation aims. Data were subjected to thematic analysis. Results Sonographers reported four main challenges: delivering a shared consultation; the requirement to resist scanning intuitively; communications during the scan; and restricted room space. Notwithstanding, all clinicians reported that participating women were accepting of the technology. Service users reported few concerns. The main benefits of fetal telemedicine were identified as upskilled staff, increased access to specialist support and improved management of complex pregnancies. Convenience was identified as the main benefit by service users, including savings in time and money from not having to travel, take time off work, and arrange childcare. Conclusions Service users and clinical stakeholders were accepting of the service. Service users reported satisfaction with communications during the consultation and awareness that telemedicine had facilitated local access to clinical expertise. Whilst clinical stakeholders reported challenges, the iterative nature of the evaluation meant that concerns were discussed, responded to, and overcome as the pilot developed. Clinical stakeholders’ perception of benefits for service users encouraged their acceptance. Moreover, the evaluation established that fetal ultrasound telemedicine is a viable method to access expertise safely and remotely. It provided demonstrable evidence of a potential solution to some of the healthcare challenges facing rural hospitals.
The Effect of Sibling Size on Children’s Educational Attainment: Evidence From Indonesia
Authors: Feng (冯乃康) Naikang 
Published: May 2020

Purpose: This study examines the effect of sibling size on children’s educational attainment in Indonesia. Design/Approach/Methods: To establish causality, it exploits the exogenous variation of sibling size caused by twin birth in families. Findings: Results of instrumental variable (IV) estimation support a traditional wisdom of quantity–quality trade-off, where sibling size is negatively correlated with the completed years of schooling, educational levels, and likelihood of school attendance. Building on this, the subsample analysis reveals that the negative effect is larger for Muslim children, children with less educated mothers, and children belonging to earlier birth cohorts. Originality/Value: These findings provide insights into both population and education policymaking in developing countries.
Saphenous Nerve Somatosensory-Evoked Potentials Monitoring During Lateral Interbody Fusion
Authors: Jain Nick , Alluri Ram , Phan Kevin , Yanni Daniel , Alvarez Andrew , Guillen Herbierto , Mnatsakanyan Lilit , Bederman S. Samuel 
Published: May 2020

Study Design.: Retrospective cohort study. Objectives: To clinically evaluate saphenous nerve somatosensory-evoked potentials (SSEPs) as a reliable and predictable way to detect upper lumbar plexus injury intraoperatively during lateral lumbar trans-psoas interbody fusion (LLIF). Methods: Saphenous nerve SSEPs were obtained by stimulation of inferior medial thigh with needle electrodes and recording from transcranial potentials. The primary outcome was measured by testing reproducibility of SSEPs at baseline, changes during the procedure, and relevance to standard modalities. Significant SSEP changes were compared with actual postoperative nerve complications. The sensitivity and specificity of saphenous SSEPs to detect postoperative lumbar plexus nerve injury was calculated. Results: A total of 62 patients were included in the study. Reliable saphenous SSEPs were recorded on the LLIF approach side in 52/62 patients. Persistent saphenous SSEP reduction of amplitude of >50% in 6 cases was observed during expansion of the tubular retractor or during the procedure. Two of 6 patients postoperatively had femoral nerve sensory deficits, and 5 of 6 patients had mild femoral nerve motor weakness, all of which resolved at an average of 12 weeks postoperatively (range 2-24 weeks). One patient had saphenous SSEP changes but demonstrated intraoperative recovery and had no postoperative clinical deficits. Saphenous SSEPs demonstrated 52% to 100% sensitivity and 90% to 100% specificity for detecting postoperative femoral nerve complications. Conclusion: Saphenous SSEPs can be used to detect electrophysiological changes to prevent femoral nerve injury during LLIF. Intraoperative SSEP recovery after amplitude reduction or loss may be a prognostic factor for final clinical outcome.
The mineralogy of the historical Mochalin Log REE deposit, South Urals, Russia. Part I. New gatelite-group minerals ferriperbøeite-(La), (CaLa3)(Fe3+Al2Fe2+)[Si2O7][SiO4]3O(OH)2 and perbøeite-(La), (CaLa3)(Al3Fe2+)[Si2O7][SiO4]3O(OH)2
Authors: Kasatkin Anatoly V. , Zubkova Natalia V. , Pekov Igor V. , Chukanov Nikita V. , Škoda Radek , Polekhovsky Yury S. , Agakhanov Atali A. , Belakovskiy Dmitriy I. , Kuznetsov Aleksey M. , Britvin Sergey N. , Pushcharovsky Dmitry Yu. 
Published: May 2020

AbstractThe paper opens a series devoted to the mineral diversity of the Mochalin Log rare earth element (REE) deposit, South Urals, Russia. There is a brief outline of the history of studies and geology of the deposit as well as the description of two new isostructural gatelite-group minerals, ferriperbøeite-(La) (CaLa3)(Fe3+Al2Fe2+)[Si2O7][SiO4]3O(OH)2 and perbøeite-(La) (CaLa3)(Al3Fe2+)[Si2O7][SiO4]3O(OH)2. Both minerals occur in polymineralic nodules and are associated with one another and allanite-(Ce), allanite-(La), bastnäsite-(Ce), bastnäsite-(La), ferriallanite-(Ce), ferriallanite-(La), ferriperbøeite-(Ce), perbøeite-(Ce), törnebohmite-(Ce) and törnebohmite-(La). The new minerals form isolated anhedral grains up to 0.3 mm [ferriperbøeite-(La)] and 0.5 mm [perbøeite-(La)] across and granular aggregates up to 1.5 mm × 0.5 mm [ferriperbøeite-(La)] and 3 mm × 1 mm [perbøeite-(La)]. Both minerals are brownish-black with vitreous lustre. Dcalc = 4.510 [ferriperbøeite-(La)] and 4.483 [perbøeite-(La)] g cm–3. They are optically biaxial (+); ferriperbøeite-(La): α = 1.788(5), β = 1.790(5), γ = 1.810(5) and 2Vmeas = 40(10)°; perbøeite-(La): α = 1.778(8), β = 1.783(8), γ = 1.805(8) and 2Vmeas = 40(10)°. Chemical data [wt.%, electron-microprobe; Fe3+:Fe2+ ratio from charge-balance requirements, H2O by stoichiometry; ferriperbøeite-(La)/perbøeite-(La)] are: CaO 4.91/4.81, ThO2 0.00/0.32, La2O3 23.75/22.16, Ce2O3 19.69/20.05, Pr2O3 0.85/1.09, Nd2O3 1.48/2.18, MgO 1.47/1.38, Al2O3 10.68/11.25, MnO 1.07/0.92, FeO 3.04/3.35, Fe2O3 5.31/3.78, TiO2 0.19/0.19, SiO2 27.47/27.35, F 0.11/0.23, H2O 1.61/1.54, –O = F –0.05/–0.10, total 101.58/100.50. The empirical formulae based on O20(OH,F)2 are for ferriperbøeite-(La): (Ca0.95La1.58Ce1.30Nd0.10Pr0.06)Σ3.99(Al2.27Fe3+0.72Fe2+0.46Mg0.40Mn0.16Ti0.03)Σ4.04Si4.96O20[(OH)1.94F0.06]; and for perbøeite-(La): (Ca0.94Th0.01La1.49Ce1.34Nd0.14Pr0.07)Σ3.99(Al2.42Fe3+0.52Fe2+0.51Mg0.38Mn0.14 Ti0.03)Σ4.00Si4.99O20[(OH)1.87F0.13]. Both minerals are monoclinic, P21/m; the unit-cell parameters [ferriperbøeite-(La)/perbøeite-(La)] are: a = 8.9458(2)/8.9652(4), b = 5.72971(13)/5.7306(2), c = 17.6192(3)/17.6770(9) Å, β = 115.9497(19)/116.053(6)°, V = 812.06(3)/815.88(6) Å3 and Z = 2/2. The crystal structures are solved on a single crystal and converged to R = 0.0355 [ferriperbøeite-(La)] and 0.0750 [perbøeite-(La)]. Ferriperbøeite-(La) and perbøeite-(La) are named as the La-analogues of ferriperbøeite-(Ce) and perbøeite-(Ce), respectively.
The amylase gene cluster in house mice (Mus musculus) was subject to repeated introgression including the rescue of a pseudogene
Authors: Linnenbrink Miriam , Ullrich Kristian K. , McConnell Ellen , Tautz Diethard 
Published: May 2020

Abstract
Background
Amylase gene clusters have been implicated in adaptive copy number changes in response to the amount of starch in the diet of humans and mammals. However, this interpretation has been questioned for humans and for mammals there is a paucity of information from natural populations.

Results
Using optical mapping and genome read information, we show here that the amylase cluster in natural house mouse populations is indeed copy-number variable for Amy2b paralogous gene copies (called Amy2a1 - Amy2a5), but a direct connection to starch diet is not evident. However, we find that the amylase cluster was subject to introgression of haplotypes between Mus musculus sub-species. A very recent introgression can be traced in the Western European populations and this leads also to the rescue of an Amy2b pseudogene. Some populations and inbred lines derived from the Western house mouse (Mus musculus domesticus) harbor a copy of the pancreatic amylase (Amy2b) with a stop codon in the first exon, making it non-functional. But populations in France harbor a haplotype introgressed from the Eastern house mouse (M. m. musculus) with an intact reading frame. Detailed analysis of phylogenetic patterns along the amylase cluster suggest an additional history of previous introgressions.

Conclusions
Our results show that the amylase gene cluster is a hotspot of introgression in the mouse genome, making it an evolutionary active region beyond the previously observed copy number changes.
Identification of QTL for resistance to root rot in sweetpotato (Ipomoea batatas (L.) Lam) with SSR linkage maps
Authors: Ma Zhimin , Gao Wenchuan , Liu Lanfu , Liu Minghui , Zhao Ning , Han Meikun , Wang Zhao , Jiao Weijing , Gao Zhiyuan , Hu Yaya , Liu Qingchang 
Published: May 2020

Abstract
Background
Sweetpotato root rot is a devastating disease caused by Fusarium solani that seriously endangers the yield of sweetpotato in China. Although there is currently no effective method to control the disease, breeding of resistant varieties is the most effective and economic option. Moreover, quantitative trait locus (QTL) associated with resistance to root rot have not yet been reported, and the biological mechanisms of resistance remain unclear in sweetpotato. Thus, increasing our knowledge about the mechanism of disease resistance and identifying resistance loci will assist in the development of disease resistance breeding.

Results
In this study, we constructed genetic linkage maps of sweetpotato using a mapping population consisting of 300 individuals derived from a cross between Jizishu 1 and Longshu 9 by simple sequence repeat (SSR) markers, and mapped seven QTLs for resistance to root rot. In total, 484 and 573 polymorphic SSR markers were grouped into 90 linkage groups for Jizishu 1 and Longshu 9, respectively. The total map distance for Jizishu 1 was 3974.24 cM, with an average marker distance of 8.23 cM. The total map distance for Longshu 9 was 5163.35 cM, with an average marker distance of 9.01 cM. Five QTLs (qRRM_1, qRRM_2, qRRM_3, qRRM_4, and qRRM_5) were located in five linkage groups of Jizishu 1 map explaining 52.6–57.0% of the variation. Two QTLs (qRRF_1 and qRRF_2) were mapped on two linkage groups of Longshu 9 explaining 57.6 and 53.6% of the variation, respectively. Furthermore, 71.4% of the QTLs positively affected the variation. Three of the seven QTLs, qRRM_3, qRRF_1, and qRRF_2, were colocalized with markers IES43-5mt, IES68-6 fs**, and IES108-1 fs, respectively.

Conclusions
To our knowledge, this is the first report on the construction of a genetic linkage map for purple sweetpotato (Jizishu 1) and the identification of QTLs associated with resistance to root rot in sweetpotato using SSR markers. These QTLs will have practical significance for the fine mapping of root rot resistance genes and play an important role in sweetpotato marker-assisted breeding.
Ischemic colitis induced by indigo naturalis in a patient with ulcerative colitis: a case report
Authors: Cho Byungha , Yoon Soon Man , Son Seung-Myoung , Kim Hyoung Woo , Kim Ki Bae , Youn Sei Jin 
Published: May 2020

Abstract
Background
Indigo naturalis is a Chinese herbal medicine that has currently been used to treat various inflammatory diseases, including ulcerative colitis. Recently, there are several reports concerning severe adverse events associated with indigo naturalis.

Case presentation
We described a case of a 44-year-old female with ulcerative colitis who presented with lower abdominal pain and hematochezia. She stopped taking her medicine for ulcerative colitis and started oral indigo naturalis 3 months before admission. Computed tomography showed segmental edematous wall thickening of the descending and sigmoid colon. Colonoscopy findings revealed erythema, edema, and submucosal hemorrhage, the surface of which presented a dark blue pigmentation. The histologic finding was consistent with ischemic colitis. We therefore considered an ischemic colitis induced by indigo naturalis, and the patient improved after supportive care and withdrawal of indigo naturalis.

Conclusion
Indigo naturalis has currently been used in the patients with ulcerative colitis as an alternative therapy. However, physicians should be aware of possible severe adverse events such as ischemic colitis.