bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the impact of the Provincial Reimbursement Scheme on the use of Targeted Anticancer Medications in Zhejiang, China: A Controlled Interrupted time-series Analysis
Authors: Huang Cong , Ung Carolina Oi Lam , Wushouer Haishaerjiang , Xu Ziyue , Zhang Yichen , Guan Xiaodong , Shi Luwen 
Published: March 2020

Abstract
Background: High prices of targeted anticancer medications (TAMs) subject patients to extreme financial burden. To alleviate problems with access and affordability, 6 TAMs were newly listed in the Provincial Reimbursement Drug List (PRDL) in Zhejiang, China in February 2015. To evaluate the implementation of the PRDL policy, this study examined differences in the hospital purchasing volume (HPV) and the hospital purchasing spending (HPS) of 6 listed TAMs pre- and post-enlistment and comparing with 4 other unlisted TAMs. Methods: Interrupted time-series analysis was employed using the pharmaceutical procurement data of 6 newly listed TAMs (study group) and 4 unlisted TAMs (control group) from 22 tertiary hospitals in Zhejiang, China dated between January 2014 and March 2017. Results: After February 2015, the average HPV per month increased significantly by 34.6 defined daily doses (DDDs) (p<0.001) and the average HPS per month increased significantly by USD 6614.9 (p<0.001) for the listed TAMs in the study group (n=6); neither the average HPV nor the average HPS changed significantly for the unlisted TAMs in the control group (n=4). Although only 4 of the 6 listed TAMs exhibited significant decrease in the monthly HPV and HPS individually, the daily cost of each TAM decreased after enlistment. Conclusions: The PRDL policy has shown positive effect on promoting the access to and improving patients’ affordability of TAMs in Zhejiang. The government should conduct further price negotiations and include more TAMs with clinical benefits into reimbursement schemes to relief patients’ financial burden and promote access.
Functional disability and associated factors among patients with severe mental illness attending psychiatry outpatient unit at Ayder comprehensive specialized hospital, Mekelle, Ethiopia: a cross-sectional study.
Authors: Amare Tesfalem , Seifu Natnael , Shewangzaw Mirkat 
Published: March 2020

Abstract
Background According to the World Health Organization (WHO), functional disability associated with severe mental illnesses was pervasive, affecting everyday life, and has a significant contribution to the global functional disability. The severe mental illnesses (schizophrenia, major depressive disorder, and bipolar disorder) were among the top ten leading causes of functional disability as indicated by years lived with a functional disability. These illnesses hurt the academic, occupational, social and family functioning of the patients. Despite this fact, functional disabilities and its contributing factors among severe mental illness were not clear. Therefore this study will assess the prevalence and associated factors of functional disabilities among patients with severe mental illnesses. Methods Institutional based cross-sectional study was conducted from Feb 03 to March 10, 2020, with a total of 423 participants in Mekelle, Ethiopia. A stratified random sampling method was included in the study. Functional disabilities were measured by WHO functional disability assessment schedule version two (WHODAS 2.0). Bivariate and multiple logistic regression analyses were performed to determine the association between independent and dependent variables. Results The prevalence of functional disability among severe mental ill patients was 88.1% (51.3% mild, 27.5% moderate & 9.3% sever functional disabilities). This study revealed that, being jobless [AOR=4.01, 95% CI (1.77, 12.35)], duration of illness ≥11 years [AOR=2.99, 95% CI(1.17,7.64)], those who had poor treatment adherence [AOR= 2.79, 95% CI (1.06, 7.35)], drug adverse effects [AOR= 4.61, 95% CI (1.79, 11.84)], poor social supports [AOR=6.58, 95% CI (2.01, 21.56)], and moderate social supports [AOR=4.16, 95% CI (1.88,9.20)] were significantly associated with functional disabilities. Conclusion The prevalence of functional disability was found to be high. Being jobless, duration of illness ≥11 years, medication non-adherent, having drug side effects and having poor or moderate social support were significantly associated with functional disabilities. Therefore, when treating patients with severe mental illness giving especial attention the bio-psycho-social aspect of treatment is essential.
Using Mixed Methods to Adapt and Evaluate the Implementation of a Multicomponent Tobacco-Free Workplace Program within Behavioral Health Centers
Authors: Leal Isabel Martinez , Chen Tzu-An , Correa-Fernández Virmarie , Le Kathy , O’Connor Daniel P. , Kyburz Bryce , Wilson William T. , Williams Teresa , Reitzel Lorraine R. 
Published: March 2020

Abstract
Background: Behavioral health treatment centers (BHTCs) rarely implement existing evidence-based practices for treating tobacco dependence, despite high rates of tobacco use among their clients. Taking Texas Tobacco Free (TTTF) has successfully targeted this disparity by delivering an evidence-based, multilevel, tobacco-free workplace program providing policy implementation and enforcement, education, provider training in tobacco screenings and treatments, and nicotine replacement therapies (NRT) to BHTCs across Texas. We describe a mixed methods design used to conduct a formative evaluation process to adapt implementation strategies to local contexts, evaluate program outcomes and characterize processes influencing program implementation in two BHTCs serving 17 clinics.Methods: Varied data collection included pre and post-implementation leader, provider, and staff surveys; and pre, mid, and post-implementation provider, staff and consumer focus groups. During implementation, data were collected via various logs (tobacco screenings, NRT delivery) to monitor program content delivery. The RE-AIM (Reach, Effectiveness, Adoption, Implementation, Maintenance) framework guided translation of behavioral interventions into sustainable practice.Results: While program implementation varied between each BHTC, all clinics adopted a 100% tobacco-free workplace policy, integrated tobacco screenings into routine practice, delivered evidence-based interventions, dispensed NRT to consumers and staff, and increased provider knowledge on how to address tobacco dependence. Pre, mid, and post-implementation qualitative findings served to: 1) develop program strategies and materials adapted to local contexts and populations and address barriers; 2) adjust delivery systems of key components to enhance implementation; 3) understand reasons for success or failure to implement specific practices; and 4) reveal program integration into clinic culture, enhancing sustainability.Conclusions: Implementation of TTTF at both BHTCs increased organizational capacity in the provision of evidence-based practices to treat tobacco dependence through successfully meeting most of our RE-AIM targets. Mixing methods involved program adopters and recipients as collaborators directly shaping core interventions to their individual context and needs, thus increasing program fit, ownership, adoption and sustainability; closing the gap between research and practice. These findings contribute to the development of flexible strategies and interventions capable of addressing variable implementation contexts and barriers, thus enhancing the effectiveness and sustainability of a tobacco-free workplace program.
Bibliometric study of the global scientific research on pain and disability
Authors: Weng Lin-Man , Zheng Yi-Li , Peng Meng-Si , Wang Juan , Wang Rui , Wang Xue-Qiang 
Published: March 2020

Abstract
Background A growing number of relevant studies on the comorbidity of pain and disability have been published in high-quality journals; however, few studies have analysed quantitatively the characteristics of the topic via bibliometrics. Purpose The study aims to systematically analyze various aspects of global scientific research on pain and disability comorbidity from 1980 to 2019 and determine the global research trend and knowledge structure. Methods A collection of publications on pain and disability comorbidity between 1980 and 2019 was retrieved from the Web of Science Core Collection. CiteSpace, Microsoft Excel 2016, and IBM SPSS Statistics 25 software were used to analyze publication outputs, authors, journals, institutions, countries, subject category, types of pain, references, and keywords. Results We collected a total of 3,570 articles in March 9, 2019. Results indicated that the publication outputs had a significant growth in the recent 40 years via the linear regression model (P<0.001). The journal Pain had the maximum output (178), the most cited frequencies in WoS (15,418), the highest impact factor index in 2017 (5.559), and the highest H-index (68). Linear regression analysis revealed that the tendency of multiple authors’ papers increased significantly (t=8.065, P<0.001). In accordance with the top 20 subject categories, Clinical Neurology was the most productive academic area (1095). With regard to types of pain, low back pain and headache were the most widely concerned with a total of 1,114 publications.Conclusion The study outlines the evolution and development of comorbid pain and disability research, reflects the overall situation and lays the groundwork for future research.
Tea tree oil prevents mastitis-associated inflammation in lipopolysaccharide-stimulated bovine mammary epithelial cells
Authors: Chen Zhi , Zhang Yi , Zhou Jingpeng , Tian Yu , Zhou Qiaoni , Mao Yongjiang , Yang Zhangping , Loor Juan J. , Gou Deming 
Published: March 2020

Abstract
Background Effective prevention and treatment of cow mastitis can provide a good guarantee for the healthy growth of cows and the qualified production of dairy products. The main purpose of this study was to explore the effect of tea tree oil on lipopolysaccharide (LPS) -induced mastitis in dairy cows, and the key gene in LPS -stimulated bovine mammary epithelial cells (BMECs) was identified. Results In this study, a model of mastitis induced by LPS was constructed, to which tea tree oil and LPS were added. The protective effects of tea tree oil on LPS-induced mastitis in BMECs were verified by the CCK-8 method, flow cytometry, real-time fluorescence quantitative detection, ELISA and other methods. The results showed that LPS at a concentration of 200 μg/ml could reduce the proliferative activity of the cells, induce a high proportion of apoptosis, and promote the expression of TNF-α, IL-6 and STAT1. Upon addition of tea tree oil, the proportion of apoptosis was reduced, and the expression of NF-κB, MAPK and caspase-3 was inhibited. Mammary epithelial cells were compared under control and LPS-treatment conditions and analyzed by second-generation sequencing. A total of 1270 mRNAs were identified as differentially expressed, of which 787 genes were upregulated and 483 were downregulated. These differentially expressed genes include TNF - α, IL6, STAT1, mapk4, etc. H&E staining and immunohistochemistry were used to verify the function of candidate genes. TNF-α and IL6 were observed to play important roles in mediating the preventive effect of tea tree oil on mastitis in LPS-stimulated bovine mammary epithelial cells. Conclusions The results showed that tea tree oil had a protective effect against LPS-induced mastitis. TNF - α and IL6 may be the marker genes of LPS-induced mastitis which provided a theoretical basis and experimental support for further research to determine new strategies for the prevention and treatment of mastitis and improvement of milk quality.
Potential Functional Variants in Innate Immune Response Genes Associated with Feed Efficiency in Beef Cattle
Authors: Ribeiro Gabriela , Cesar Aline Silva Mello , Alexandre Pâmela Almeida , Ferraz José Bento Sterman , Fukumasu Heidge 
Published: March 2020

Abstract
Background: Identifying and selecting animals for feed efficiency (FE) is extremely important for the beef production chain. Currently, the most common parameter to access the FE animals is residual feed intake (RFI), which is the residual of the linear regression that estimates DMI based on average daily gain and mid-test metabolic body weight. However, it relies on costly and time-consuming data collection, creating a growing demand for alternative approaches to identify genetically superior animals for FE. This study aimed to detect potential liver-specific functional variants from RNA-seq data of 16 Nellore bulls divergently selected for FE. Results: The variant call analysis detected 247 missense SNPs and nine insertion-deletions (INDELs) that alter the protein functions. These variants were found within 190 genes differentially found (P < 0.05) in liver tissue between high FE (HFE) and low FE (LFE) animals. To better understand the role of these variants in biological pathways, we performed a functional enrichment analysis, which highlighted six genes involved in complement cascade and cascade complement regulation pathways, and 20 genes involved in the regulation of the innate immune system. They had four different significant variants in the complement factor H (CFH) family genes, and all were homozygous in HFE animals rather than some degree of heterozygous in LFE animals. Conclusion: We developed a pipeline to detect potential liver-specific functional variants from RNA-seq data from animals divergently selected for feed efficiency. With this approach, we found potential functional variants in innate immune response genes associated with feed efficiency in beef cattle.
Effects of Lactobacillus plantarum BCC65951 inoculation in Napier Pakchong 1 silage on in vitro rumen degradability and growth performance of Brahman cattle
Authors: Yammuen-art Saowaluck , Khemarach Soparak , Taja Kattareeya , Plengvidhya Vethachai , Phaopaisal Ittiphon , Kongtong Kittima , Sangsritavong Siwat 
Published: March 2020

Abstract
Background: Napier grass Pakchong 1 is used as a fodder crop in Southeast Asia. Unfortunately, its fermentation for silage production is challenging owing to the low dry mass content and epiphytic lactic acid bacteria. Here, Lactobacillus plantarum BCC65951 (LAB) inoculation was tested for impact on silage fermentation and use. Silage was prepared with or without inoculation of LAB and stored for 180 days prior to analysis.Results: Gas production at 4-24 h was significantly higher in LAB group (P=0.001). Therefore, the result implied the faster ruminal degradation of LAB, especially during the first 24 h. LAB-inoculated silage exhibited greater levels of lactic acid and in vitro rumen degradability compared to control silage, and significantly lower pH and acetic acid content. To investigate the effect of LAB inoculation on animal performance, ten Brahman bulls were fed on control or LAB-inoculated silage in a crossover experimental design. Animals fed with LAB-inoculated silage had significantly higher voluntary roughage intake and greater average daily body weight gain than those fed with control silage.Conclusions: Results from this study revealed the beneficial effect of Napier Pakchong 1 ensiled with L. plantarum BCC65951 inoculation, both on the fermentative quality of the silage and also the performance of animals fed with the inoculated silage.
Contextual Effects of Social Integration and Disintegration on Health Status: Evidence from South Korea
Authors: Jung Minsoo , Jo Eun-Bi , Kwon Rang Hee 
Published: March 2020

Abstract
Background: Many studies have shown that various social integration variables represented by social capital are beneficial to communities, including collective health. However, the rapid decline in fertility rates and the breakup of familism in developed countries require a new approach to social disintegration, but the literature is insufficient. We explored the contextual effects of social integration and social disintegration on the health of individuals.Methods: The research data consist of merged datasets of 6909 respondents who were quota-sampled by approximately 30 people from 229 local governments in Korea. The individual-level independent variable is a social integration measure consisting of 26 questions in four areas. The community-level independent variables are five integral and aggregate variables extracted from 81 indicators. The dependent variable is self-rated health status.Results: The results showed that at the individual level, the higher the inclusive attitude of in- and out-of-networks, after adjusting for potential confounders, the less likely the respondent belongs to the unhealthy group (p <0.001). At the community level, the higher the proportion of single-person households in a community after adjusting for potential confounders, the less likely the respondent belongs to the unhealthy group (p <0.05).Conclusion: Thus far, social integration has been preferred, with the positive aspects of social capital being emphasized. However, this study shows that in some cases, social disintegration can instead positively influence an individual's health. Therefore, further studies of the various conditions of social context effects on health are necessary.
‘I’ve got to be independent’: Older peoples’ views on recovery following road injury: A qualitative study
Authors: Brown Katherine , Cameron Ian D , Keay Lisa , Nguyen Ha , Dillon Lisa , Jagnoor Jagnoor , Ivers Rebecca 
Published: March 2020

Abstract
Background: Mild to moderate severity road injury in people of working age is associated with limited recovery. Less is known about people who sustain road injury in older age. This study explored perspectives, and factors related to recovery and health-related quality of life following road injury in older age. Methods: A qualitative study using content analysis was undertaken. Participants aged 65 or more years were purposively selected from a larger inception cohort study of health outcomes following mild to moderate severity road injury. Semi-structured interviews were undertaken at approximately 12 or 24 months after injury. Content analysis was used to code and analyse the data, with methodological rigour obtained by double-coding and discussing a portion of the data to reach consensus. Results were reported using the consolidated criteria for reporting qualitative research (COREQ). Results: Nineteen participants were invited to participate in the study, with thematic saturation reached after the 12 th interview. Recovery experiences were diverse. Five main themes were identified: recovery is regaining independence; injury & disability in older age; the burden of non-obvious disability; the importance of support, and positive personal approaches. Key facilitators of recovery were regaining independence; support from family and friends, and positive personal approaches. Key barriers were threats to independence; passive coping behaviours; non-obvious disabilities (chronic pain, psychological impacts), and for some, a reluctance to raise ongoing issues with General Practitioners. Threats to independence, especially not driving and self-care, appeared to have a more profound effect on recovery than physical functioning. Conclusion: Older people view injury as a threat to independent functioning. This is somewhat different to what younger people report. Regaining independence is key to older peoples’ recovery and health-related quality of life following road injury, and should be a key consideration for health professionals, services and supports working with this unique cohort. Greater efforts to help older people regain independence following road injury are needed and can be facilitated by health professionals and appropriate service provision.
Nomads' access to the current healthcare system is impaired by their perception of its cost, quality, and accessibility and by gender segregation in Timbuktu, Mali: A cross-sectional study
Authors: Sangare Moussa , Coulibaly Yaya Ibrahim , Coulibaly Siaka Yamoussa , Dolo Housseini , Diabate Abdoul Fatao , Atsou Kueshivi Midodji , Souleymane Abdoul Ag , Rissa Youssouf Ag , Moussa Dada Wallet , Abdallah Fadimata Wallet , Dembele Massitan , Traore Mahamadou , Diarra Tieman , Brieger William R. , Traore Sekou Fantamady , Doumbia Seydou , Diop Samba 
Published: March 2020

Abstract
Background Access to community-based healthcare services is one of the key characteristics in successful public health policy. In Mali, community-based interventions do not reach nomadic communities, remote and hard-to-reach areas. Methods: In order to determine a better healthcare strategy for these nomadic populations, we conducted a cross-sectional survey in the administrative region of Timbuktu in Mali using the administration of questionnaires to community members. Results: A total of 520 individuals from two nomadic communities, Gossi and Ber, were included in the questionnaire survey. Inhabitants of the two nomadic communities were livestock breeders (27%), housekeepers (26.4%), local traders (11%), farmers (6 %) and artisans (5.5%). The median age of the study participants was 38 years (18-86 years). The participants from Gossi and Ber lived at a mean distance of 40.94 km and 23.19 km from the closest health center, respectively. The major complaints with respect to accessing healthcare were cost (35.7%), distance to the health center (46.2%), quality of the provided services (39.2 %) and means of transportation (79.4%). More than 25% of the participants from the community stated that they will never accept to being examined by a health care provider of the opposite gender. Conclusion It appears from the interviews results that these nomadic populations have health needs not presently covered by the current health delivery system. Tackling the method and organization of health care delivery by adapting them to the local lifestyle, culture and values could lead to significant improvements health outcomes.