bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvements to Lake-Effect Snow Forecasts Using a One-Way Air–Lake Model Coupling Approach
Authors: Fujisaki-Manome Ayumi , Mann Greg E. , Anderson Eric J. , Chu Philip Y. , Fitzpatrick Lindsay E. , Benjamin Stanley G. , James Eric P. , Smirnova Tatiana G. , Alexander Curtis R. , Wright David M. 
Published: August 2020

AbstractLake-effect convective snowstorms frequently produce high-impact, hazardous winter weather conditions downwind of the North American Great Lakes. During lake-effect snow events, the lake surfaces can cool rapidly, and in some cases, notable development of ice cover occurs. Such rapid changes in the lake-surface conditions are not accounted for in existing operational weather forecast models, such as the National Oceanic and Atmospheric Administration’s (NOAA) High-Resolution Rapid Refresh (HRRR) model, resulting in reduced performance of lake-effect snow forecasts. As a milestone to future implementations in the Great Lakes Operational Forecast System (GLOFS) and HRRR, this study examines the one-way linkage between the hydrodynamic-ice model [the Finite-Volume Community Ocean Model coupled with the unstructured grid version of the Los Alamos Sea Ice Model (FVCOM-CICE), the physical core model of GLOFS] and the atmospheric model [the Weather Research and Forecasting (WRF) Model, the physical core model of HRRR]. The realistic representation of lake-surface cooling and ice development or its fractional coverage during three lake-effect snow events was achieved by feeding the FVCOM-CICE simulated lake-surface conditions to WRF (using a regional configuration of HRRR), resulting in the improved simulation of the turbulent heat fluxes over the lakes and resulting snow water equivalent in the downwind areas. This study shows that the one-way coupling is a practical approach that is well suited to the operational environment, as it requires little to no increase in computational resources yet can result in improved forecasts of regional weather and lake conditions.
The Nonlinear Impacts of Global Warming on Regional Economic Production: An Empirical Analysis from China
Authors: Chang Jun-Jie , Wei Yi-Ming , Yuan Xiao-Chen , Liao Hua , Yu Bi-Ying 
Published: August 2020

AbstractChina, the second largest economy in the world, covers a large area spanning multiple climate zones, with varying economic conditions across regions. Given this variety in climate and economic conditions, global warming is expected to have heterogeneous economic impacts across the country. This study uses annual average temperature to conduct an empirical research from a top-down perspective to evaluate the nonlinear impacts of temperature change on aggregate economic output in China. We find that there is an inverted U-shaped relationship between temperature and economic growth at the provincial level, with a turning point at 12.2°C. The regional and national economic impacts are projected under the shared socioeconomic pathways (SSPs) and representative concentration pathways (RCPs). As future temperature rises, the economic impacts are positive in the northeast, north, and northwest regions but negative in the south, east, central, and southwest regions. Based on SSP5, the decrement in the GDP per capita of China would reach 16.0% under RCP2.6 and 27.0% under RCP8.5.
Type D Personality and Myocardial Infarction: A Case-Control Study
Authors: Manoj MT , Joseph KA , Vijayaraghavan Govindan 
Published: August 2020

Background: Coronary heart disease (CHD) is an impending global pandemic in developed countries as well as developing countries and economies in transition, such as India. A significant increase in the incidence of myocardial infarction (MI), one of the most common types of CHD, is being reported in India, and the incidence and severity of the disease are more among the youth in Kerala. Studies assessing the association between psychological factors and MI are few in India. Methods: We adopted a case-control study design. A total of 150 cases (with MI) and 150 controls (without MI and matched for age and gender) from a tertiary care hospital in Trivandrum, Kerala, India, were selected using convenient sampling method, between September 2016 and August 2017. Results: As compared to 33.3% of the controls, 50.7% of patients with MI had type D personality characteristics. Multivariate logistic regression analysis after adjusting for the confounders indicated a positive and statistically significant association between type D personality and MI: OR = 4.14, 95% CI = 2.19–8.85, P = 0.003. Conclusion: Type D personality is associated with MI.
Impact of gender, albumin, and CYP2C19 polymorphisms on valproic acid in Chinese patients: a population pharmacokinetic model
Authors: Guo Jinlin , Huo Yayu , Li Fang , Li Yuanping , Guo Zhaojun , Han Huaqing , Zhou Yuhong 
Published: August 2020

Objective This prospective study aimed to establish the valproic acid (VPA) population pharmacokinetic model in Chinese patients and realise personalised medication on the basis of population pharmacokinetics. Methods The patients’ clinical information and VPA plasma concentrations were collected from The General Hospital of Taiyuan Iron & Steel (Group) Corporation (TISCO). Nonlinear mixed-effect modelling was used to build the population pharmacokinetic model. To characterise the pharmacokinetic data, a one-compartment pharmacokinetic model with first-order absorption and elimination was used. The first-order conditional estimation with η-ε interaction was applied throughout the model-developing procedure. The absorption rate constant (Ka) was fixed at 2.38 hour−1, and the impact of covariates on clearance and apparent volume of distribution were also explored. Medical records of 60 inpatients were reviewed prospectively and the objective function value (OFV) of the base model and final model were 851.813 and 817.622, respectively. Results Gender was identified as the covariate that had a significant impact on the volume of distribution, and albumin and CYP2C19 genotypes influenced clearance. Conclusion Bootstrap and VPC indicated that a reliable model had been developed that was based on the simulation results, and a simple-to-use dosage regimen table was created to guide clinicians for VPA drug dosing.
Time of day and mammographic reader performance in a population-based breast cancer screening programme
Authors: Backmann Heinrich A , Larsen Marthe , Danielsen Anders S , Hofvind Solveig 
Published: August 2020

Objectives To analyse how reader performance varied by time during the day in a population-based breast cancer screening programme. Methods A total of 2,937,312 readings from 148 radiologists and 1,468,656 women were included in this study from Norway. Number and percentages of mammographic readings, positive scores, true and false positive readings, true and false negative readings, sensitivity and specificity were presented for categories of time of day and for each day of the week. Multilevel mixed effect logistic regression models with restricted cubic splines were fitted to the data, and used to predict the odds ratio of the different performance measures. Results The following distribution was found for the performance measures during the study period: true positive: 12,463 (0.4%); false positive: 128,419 (4.4%); true negative: 2,794,636 (95.1%); and false negative: 1794 (0.06%). The percentage of positive readings (true positive and false positive) was highest before lunch and in the early afternoon (4.9%): false positive was highest in both periods (4.5%) and true positive was highest in the early afternoon (0.5%). The percentage of true negative was highest in the evening (95.6%), and of false negative was highest at lunchtime (0.07%). This corresponds to a gradually decreasing predicted sensitivity throughout the day. The opposite was observed for specificity. Conclusions Screen-reading early versus late during the day resulted in higher sensitivity, although at the cost of specificity. Despite small differences in the performance measures during the day, the results may be important in the discussion of optimal management of screening programmes.
Bilingual language dominance and contrastive focus marking: Gradient effects of K’ichee’ syntax on Spanish prosody
Authors: Baird Brandon O. 
Published: August 2020

Aims and objectives/purpose/research questions: This study examines prosodic contrastive focus marking in the Spanish of 24 simultaneous K’ichee’-Spanish bilinguals via the following research questions: (1) How do K’ichee’-Spanish bilinguals prosodically mark contrastive focus in Spanish? (2) Is there evidence of K’ichee’ influence in Spanish prosody and is this possible K’ichee’ influence correlated with the language dominance of the bilinguals? Design/methodology/approach: Participants produced utterances in both broad and contrastive focus conditions via a question-answer task. Data and analysis: Tonic syllables of 1638 target words were analyzed according to L- and H-tone alignment and the rise of the pitch contour. Data were analyzed via linear mixed-effects models according to pragmatic condition (categorical effect) and language dominance (continuous effect). Findings/conclusions: Results indicate gradient effects of language dominance of possible K’ichee’ influence. Spanish-dominant bilinguals tend to prosodically mark contrastive focus to a greater degree than K’ichee’-dominant bilinguals. It is proposed that this may be due to the different focus marking strategies between K’ichee’ and Spanish. K’ichee’ primarily marks contrastive focus syntactically whereas it is much more common in Spanish to only mark contrastive focus prosodically. Originality: This study employs a modified version of the question-answer task, which uses video clips to elicit the data in order to include participants with low literacy rates and control the elicitations. It also provides one of the first analyses of intonation in Guatemalan Spanish and the task and data allow for direct comparisons with the K’ichee’ data produced by these same bilinguals. Significance/implications: These results parallel those of similar studies: among bilinguals, the syntactic contrastive focus marking strategy of one language may affect the prosodic contrastive focus marking strategy of their other language. Additionally, the use of language dominance as a continuous variable expands our understanding of inter-speaker variation in such studies.
Choice, control and person-centredness in day centres for older people
Authors: Orellana Katharine , Manthorpe Jill , Tinker Anthea 
Published: August 2020

Background Day centres are a substantial element of community-based support for older people in many countries. However, assumptions that they are an outdated or costly service model have resulted in many centre closures in England. The perspectives of 42 people attending, providing, making referrals to or purchasing places at four diverse day centres for older people were collected in interviews. Using these data, we explore day centres’ relevance to social workers’ efforts to promote person-centred support for older people enabling them to maintain or improve their well-being. These are explored from the perspectives of choice, control and person-centredness and local authority responsibilities for shaping the care market under the Care Act 2014. Findings Attenders highly valued centres’ congregate nature and the continuity they offered which contributed to the development of person-centred relationships. Attenders exercised choice in attending day centres. Social work staff were more positive about day centres’ relevance to personalisation than those responsible for making decisions about the shape of local care services. Applications With social isolation recognised as a serious risk of old age, the value of togetherness in group environments may need highlighting. Enactment of personalisation policies need not necessarily lead to individualisation; day centres may be community-based assets for some. Those shaping the care market may be encouraged to acknowledge wider outcomes, and frontline social workers may benefit from hearing positive experiences that may help in the development of effective care plans for older people who would like to benefit from day centre participation.
Predictors of mortality for patients with COVID-19 and large vessel occlusion
Authors: Altschul David J , Esenwa Charles , Haranhalli Neil , Unda Santiago R , de La Garza Ramos Rafael , Dardick Joseph , Fernandez-Torres Jenelys , Toma Aureliana , Labovitz Daniel , Cheng Natalie , Lee Seon-Kyu , Brook Allan , Zampolin Richard 
Published: August 2020

Background This study evaluates the mortality risk of patients with emergent large vessel occlusion (ELVO) and COVID-19 during the pandemic. Methods We performed a retrospective cohort study of two cohorts of consecutive patients with ELVO admitted to a quaternary hospital from March 1 to April 17, 2020. We abstracted data from electronic health records on baseline, biomarker profiles, key time points, quality measures and radiographic data. Results Of 179 patients admitted with ischemic stroke, 36 had ELVO. Patients with COVID-19 and ELVO had a higher risk of mortality during the pandemic versus patients without COVID-19 (OR 16.63, p = 0.004). An age-based sub-analysis showed in-hospital mortality in 60% of COVID-19 positive patients between 61-70 years-old, 66.7% in between 51-60 years-old, 50% in between 41-50 years-old and 33.3% in between 31-40 years old. Patients that presented with pulmonary symptoms at time of stroke presentation had 71.4% mortality rate. 27.3% of COVID-19 patients presenting with ELVO had a good outcome at discharge (mRS 0-2). Patients with a history of cigarette smoking (p = 0.003), elevated d-dimer (p = 0.007), failure to recanalize (p = 0.007), and elevated ferritin levels (p = 0.006) had an increased risk of mortality. Conclusion Patients with COVID-19 and ELVO had a significantly higher risk for mortality compared to COVID-19 negative patients with ELVO. A small percentage of COVID-19 ELVO patients had good outcomes. Age greater than 60 and pulmonary symptoms at presentation have higher risk for mortality. Other risk factors for mortality were a history of cigarette smoking, elevated, failure to recanalize, elevated d-dimer and ferritin levels.
Reversal of age-associated oxidative stress in mice by PFT, a novel kefir product
Authors: Ghoneum Mamdooh , Abdulmalek Shaymaa , Pan Deyu 
Published: August 2020

Introduction: Oxidative stress is a key contributor to aging and age-related diseases. In the present study, we examine the protective effects of PFT, a novel kefir product, against age-associated oxidative stress using aged (10-month-old) mice. Methods: Mice were treated with PFT orally at a daily dose of 2 mg/kg body weight over 6 weeks, and antioxidant status, protein oxidation, and lipid peroxidation were studied in the brain, liver, and blood. Results: PFT supplementation significantly reduced the oxidative stress biomarkers malondialdehyde (MDA) and nitric oxide; reversed the reductions in glutathione (GSH) levels, total antioxidant capacity (TAC), and anti-hydroxyl radical (AHR) content; enhanced the antioxidant enzyme activities of glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD); inhibited the liver enzyme levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT); significantly reduced triglyceride (TG), total cholesterol (TC), and low density lipoprotein (LDL) levels; and significantly elevated high density lipoprotein (HDL) levels. Interestingly, PFT supplementation reversed the oxidative changes associated with aging, thus bringing levels to within the limits of the young control mice in the brain, liver, and blood. We also note that PFT affects the redox homeostasis of young mice and that it is corrected post-treatment with PFT. Conclusion: Our findings show the effectiveness of dietary PFT supplementation in modulating age-associated oxidative stress in mice and motivate further studies of PFT’s effects in reducing age-associated disorders where free radicals and oxidative stress are the major cause.
Managing COPD with expiratory or inspiratory pressure load training based on a prolonged expiration pattern
Authors: Miki Keisuke , Tsujino Kazuyuki , Miki Mari , Yoshimura Kenji , Kagawa Hiroyuki , Oshitani Yohei , Fukushima Kiyoharu , Matsuki Takanori , Yamamoto Yuji , Kida Hiroshi 
Published: August 2020

BackgroundExertional prolonged expiration should be identified as a therapeutic target in COPD. The efficacy of expiratory or inspiratory pressure load training (EPT/IPT) based on the degree of prolonged expiration was investigated.MethodsA total of 21 patients with COPD were divided into two groups according to the exertional change in the inspiratory duty cycle (TI/Ttot). For 12 weeks, patients whose exertionalTI/Ttot decreased received EPT (EPT group, n=11, mean percentage forced expiratory volume in 1 s (%FEV1), 32.8%) and those whose exertionalTI/Ttot increased received IPT (IPT group, n=10, mean %FEV1, 45.1%).ResultsThe therapeutic responses were as follows. In both groups, endurance time (EPT, +5.7 min, p<0.0001; IPT, +6.1 min, p=0.0004) on the constant work rate exercise test (WRET) and peak oxygen uptake increased (EPT, p=0.0028; IPT, p=0.0072). In the EPT group the following occurred: 1) soon after commencement of exercise with the constant WRET, the expiratory tidal volume (VTex) increased, reducing dyspnoea; 2)VTex and mean expiratory flow increased and then prolonged expiration (p=0.0001) improved at peak exercise with the incremental exercise test (ET); and 3) St. George's Respiratory Questionnaire total, activity and impact scores were improved. In the IPT group, on both the constant WRET and incremental ET, breathing frequency increased, which led to greater exercise performance with effort dyspnoea.ConclusionsThis study showed the benefits of EPT/IPT on exercise performance. If the choice of managing COPD with EPT/IPT is appropriate, inexpensive EPT/IPT may become widespread as home-based training.
Definitive surgery of primary lesion should be prioritized over preoperative chemotherapy to treat high-grade osteosarcoma in patients aged 41–65 years
Authors: Hayakawa Keiko , Matsumoto Seiichi , Ae Keisuke , Tanizawa Taisuke , Funauchi Yuki , Minami Yusuke , Saito Masanori , Okawa Atsushi 
Published: August 2020

Abstract
Background
Recently, the number of osteosarcomas in middle-aged and older patients has demonstrated an increasing trend; moreover, their results are comparatively worse than those of young patients. In Europe and the USA, the prognosis for osteosarcoma in middle-aged and older patients has improved with adjuvant chemotherapy. In Japan, however, the prognosis has remained poor.

Materials and Methods
We retrospectively analyzed the outcomes of osteosarcoma, especially in regards to preoperative chemotherapy, from January 1980 to July 2014. A total of 29 patients with high-grade osteosarcoma between the age of 40 and 65 years were included. We included patients without distant metastasis and with primary lesions that were deemed resectable. The mean age was 52.8 years (range 41–65 years), and the mean follow-up period was 103.2 months (range 5–314 months).

Results
Adjuvant chemotherapy was administered to 27 of 29 patients (93%), and 8 of 15 cases (53%) were able to undergo preoperative chemotherapy as planned, including CDDP. A major complication of chemotherapy was acute kidney injury due to CDDP (26%). The 5-year OS and 5-year EFS were 64.9% and 57.1%, respectively. After 2006, a policy to prioritize the resection of the primary lesion was implemented, and if the primary lesion was deemed resectable, preoperative chemotherapy was either not administered or administered for only a short duration. The 5-year OS after 2006 improved to 78.8%.

Conclusions
This study shows that administration of high-dose intensity preoperative chemotherapy was difficult in middle-aged and older patients due to their high rate of acute kidney injury by CDDP. For cases of osteosarcoma in middle-aged and older patients, if the primary lesion is resectable, preoperative chemotherapy should be minimized to prioritize the resection of the primary lesion. It was considered that, with appropriate measures to prevent complications, adjuvant chemotherapy may lead to improved prognosis.

Level of evidence
V.
Clinical and imaging profiles of pulmonary embolism: a single-institution experience
Authors: Al Dandan Omran , Hassan Ali , AbuAlola Hossain , Alzaki Alaa , Alwaheed Abrar , Alalwan Mohannad , Al Shammari Malak , AlShamlan Nouf , Alsaif Hind S. 
Published: August 2020

Abstract
Background
Pulmonary embolism (PE) is a common life-threatening condition with non-specific clinical presentations. The diagnosis of PE depends highly on imaging studies, which may also provide prognostic information. This study aimed to describe the clinical and imaging profiles of patients with PE, emphasizing the differences between central and peripheral PE.

Methods
After ethics review board approval, this retrospective observational study examined the non-negative results in adult patients who underwent computed tomography pulmonary angiography (CT-PA) at our hospital between May 2016 and December 2019. Demographic and clinical information and imaging findings were collected from the electronic medical records.

Results
The study included 85 cases that were identified after re-interpreting the 103 non-negative CT-PA scans. Six cases were excluded for incomplete data and 12 cases were false-positive. Central PE was found in 63.5% of the cases. Obesity was the most common risk factor seen in 37.6% of the cases. Furthermore, 9.4% of the patients had sickle cell disease, which tended to be associated with peripheral PE. There was no difference between the peripheral and central PE in most clinical and imaging parameters evaluated (P > 0.05). However, patients with isolated subsegmental PE were more likely to develop hemoptysis (P = 0.04).

Conclusion
This study suggests that patients with obesity and sickle cell disease constitute an important proportion of all PE cases. Furthermore, the clinical and imaging profiles in patients with peripheral PE are similar to those in patients with central PE. Future research should focus on the clinical value of peripheral PE in patients with sickle cell disease.