bluuebunny/crossref_metadata_2025_split huggingface dataset:
Practical solutions for implementation of Transition to Practice curricula in a competency-based medical education model.
Authors: Sanaee Layli , Glover Takahashi Susan , Nayer Marla 
Published: April 2020

Background: Although transition from residency to practice represents a critical learning stage, there is a paucity of literature to inform local curriculum development and implementation.Objectives: To describe local curriculum development for Transition to Practice (TTP) for use within a competency-based medical education model, including important content and suitable teaching and assessment strategies.
Design: We reviewed the literature to construct a definition and develop initial curriculum content for TTP. We then gathered local residency program directors’ views on TTP content, teaching, and assessment via online survey and an international educational conference workshop.
Results: We identified 21 important TTP content areas in the literature and analyzed 35 survey responses, representing 33 residency programs. Survey participants viewed Further sophistication of clinical skills, How to set up a practice, and Time management skills as the three most important content areas. Views on content importance varied by program. For learning and teaching strategies, most respondents preferred: assessing what residents could do, providing real-life practice opportunities, and offering workplace-based assessments.
Conclusions: TTP curricula implementation should reflect nationally set, specialty-specific curriculum elements; locally developed priority content; and learning and teaching strategies. Individual learner needs and imminent practice context should guide faculty approaches to curriculum delivery.
ENDEMIC SPRING SNAILS TERRESTRIBYTHINELLA (MOLLUSCA) AS UNUSUAL MATERIAL FOR LARVAL CASE OF CRUNOECIA IRRORATA (TRICHOPTERA: LEPIDOSTOMATIDAE) IN TRANSCARPATHIAN UKRAINE
Authors: Martynov Alexander V. , Anistratenko Vitaliy V. , Furyk Yurii I. 
Published: April 2020

An unusual larval case of Crunoecia irrorata (Curtis, 1834) (Trichoptera, Lepidostomatidae) was collected in a small stream in Ukrainian Transcarpathia. This larval case consisted mainly of living snails of extremely rare endemic gastropod mollusk of the genus Terrestribythinella Sitnikova, Starobogatov & Anistratenko, 1992 (Gastropoda: Terrestribythinellidae). The larval case, distinguishing characters of C. irrorata larva and its habitat are illustrated. Ecological relations between shell-utilizing caddisfly larvae and mollusks used as material for larval cases are discussed.
Pengaruh Penyusunan Rencana Pembangunan Terhadap Pengentasan Kemiskinan Dengan Partisipasi Masyarakat Desa Sebagai Moderating Variabel Pada Beberapa Desa di Kabupaten Gorontalo
Authors: Husain Walidun 
Published: April 2020

<p class="Default">Tujuan penelitian ini adalah untuk menganalisis secara empiris seberapa besar pengaruh penyusunan rencana pembangunan desa dengan partisipasi masyarakat desa sebagai moderating variabel secara silmultan terhadap pengentasan kemiskinan; menganalisis secara empiris seberapa besar pengaruh penyusunan rencana pembangunan desa terhadap pengentasan kemiskinan; serta menganalisis secara empiris seberapa besar pengaruh partisipasi masyarakat terhadap pengentasan kemiskinan. Setelah dilakukan penelitian pada sampel 110 responden pada beberapa perangkat pemerintah desa di kabupaten Gorontalo dan dengan analisis data metode MRA (<em>Moderated Regression Analysis)</em>, maka diperoleh bahwa penyusunan rencana pembangunan berpengaruh positif terhadap pengentasan kemiskinan pada desa-desa di Kabupaten Gorontalo.; juga variabel partisipasi masyarakat desa berpengaruh terhadap pengentasan kemiskinan pada desa-desa di Kabupaten Gorontalo; serta penyusunan rencana pembangunan berpengaruh positif terhadap pengentasan kemiskinan pada partisipasi masyarakat desa sebagai Moderating Variabel yang tinggi pada desa-desa di Kabupaten GOrontalo. Dengan demikian maka dapat disimpulkan bahwa variabel partisipasi masyarakat desa dapat memoderasi pengaruh penyusunan rencana pembangunan desa terhadap pengentasan kemiskinan pada desa-desa di Kabupaten Gorontalo</p>
Investigation of Home Health Services and Expectations of Patients and Patient Relatives: A Study Case in Bakirkoy District
Authors: TAMER Gülay 
Published: April 2020

Aim: The aim of this study is to examine the expectations and demands of patients and their relatives' in-home health care. In the scope of the study, narrow area as the study was being carried out in the Bakirkoy district of Istanbul province.Method: In the scope of the study, questionnaires were distributed to 83 people in Istanbul who were satisfied with home health care services, but 70 people were returned. The analysis was conducted on 70 people. The research is a descriptive survey model. A questionnaire was used as a data collection tool. The questionnaire forms consist of questions about demographic and home health service evaluation scale. Results: When the opinions of the patients and their relatives were evaluated in terms of home care services, the mean values of all expressions in the home health service evaluation questionnaire were over 4. Conclusion: This indicates that patients who are receiving home care services and their relatives have positive perceptions about home care services. The satisfaction of the patients and their relatives are very high for home care services.
İç Hastalıkları Kliniğine Yatışı Yapılan Diyabetes Mellitüs Tanılı Hastaların Birimlerine Göre Maliyet Analizi
Authors: ŞEKER Ömer , KÖROĞLU Mehmet , OKUTURLAR Yıldız 
Published: April 2020

Amaç: Gelişmiş ülkelerde Diyabetes Mellitüs (DM) tanılı hastaların yıllık giderleri değerlendirildiğinde giderlerin hastane yatışı ve tedaviler, komplikasyonların tedavisi, antidiyabetik ilaçlar ve ajanlar, doktor ziyaret ücretleri, hemşirelik ve bakım hizmetleri ve acil servis başvuruları için harcandığı görülmüştür. Bu çalışmada İç Hastalıkları kliniğine yatırılan hastaların maliyet analizleri planlanlanmıştır. Yöntem: Bu çalışmada 01.01.2011-30.09.2014 tarihleri arasında İç Hastalıkları kliniğine yatırılan Tip 1 ve Tip 2 DM tanısı alan hastalar bilgisayar verilerinden taranmıştır. Hastaların yaş, cinsiyet, yatış süreleri, yıllara göre yatış dağılımı, kaç kez yattıkları, sosyal güvenceleri, toplam yatış maliyetleri ve birimlere göre yatış maliyetleri gruplandırılarak kaydedilmiştir.Bulgular: Diyabet tanılı hastaların yıllık giderlerini araştıran birçok çalışma ile birlikte bu çalışma değerlendirdiğimizde giderler içerisinde ilaç harcamalarının ve laboratuvar tetkiklerinin yanı sıra komplikasyonların tanısı ve tedavisinin de önemli yer tuttuğunu tespit edilmiştir. Çalışmada medikal tedavilerin, laboratuvar analizlerinin, yatak ücretlerinin yanında hemodiyaliz giderlerinin ön planda olması beklenildiği gibi hasta grubunda renal komplikasyonların sık görülmesiyle açıklanabilir. Bu çalışma, yurtdışındaki benzer çalışmalarla karşılaştırıldığında hekim vizitlerinin maliyete katkısının oldukça düşük olduğunu saptanmıştır. Sonuç: Tüm elde edilen veriler göz önüne alındığında; giderek daha önemli bir sağlık problemi olan Diyabetes Mellitüs tedavisinde daha başarılı olmak ve maliyeti düşürebilmek amacıyla hastaların hastalık ve komplikasyonları hakkında detaylı bilgilendirilmesinin ve düzenli aralıklarla doktor tarafından takip edilmesinin önemli olduğu kanaatine varılmıştır.
Documentation of Local Health Traditions of Yadgir District, Karnataka
Authors: Naik Raghavendra , Doddamani Shashidhar H , Rao V Rama , Shiddamallayya N , Dixit Amit K , Rath Chinmay , Mangal Anupam K 
Published: April 2020

Aim:
The traditional medicinal practice in India includes different aspects of health such as prevention, promotion, and healing. Since there is need for documenting this traditional medicinal practice prevalent in different parts of the country for the preservation of the knowledge, the present study was undertaken to record the traditional knowledge of medicine from Yadgir district of Karnataka.

Materials and methods:
A Medico-Ethno Botanical survey was undertaken in the Yadgir district of Karnataka between September and December 2017. Data were collected from traditional healers and locals by means of personal interviews using a prescribed format.

Results:
A total of 20 folk claims used for the treatment of 16 different disease conditions were recorded. The remedies were mostly prepared in the form of decoction, paste, poultice, juice, etc. and were mainly taken orally. Eczema, paralysis, toothache, wound obesity, diabetes, fever, jaundice, fracture, cough, anemia etc. are some of the diseases usually treated by traditional practitioners. Only single ingredient was used in 16 documented claims whereas remaining 4 are compound preparations having more than one ingredient. It is observed that, most of the medicinal plants are used in fresh form, after collecting from their natural habitat whenever necessary.

Conclusion:
Since the documentation of traditional knowledge on medicinal uses of plants is vital for the future generation, this study could serve an important role in fulfilling this purpose.

Clinical significance:
The documented data can also serve as a base for the development of new medicines by scientific studies.
Multiplication of Bharangi—Clerodendrum serratum (L.) Moon
Authors: Gurav Arun M , Mhase Archana G , Nirawane Rekha R , Kolhe Rasika , Goli Penchala P , Mangal Anupam K , Srikanth Narayanam 
Published: April 2020

Aim:
To develop effective in vitro multiplication protocol for rare and endangered medicinal plants of Clerodendrum serratum (L.) Moon.

Materials and methods:
Trials were carried out using nodal segments as explants, which were inoculated on Murashige and Skoog medium (MS) plain medium and different concentrations of phytohormones viz., benzylaminopurine (BAP), kinetin (Kn), indol-3-butyric acid (IBA), indol-3-acetic acid (IAA), and naphthaleneacetic acid (NAA), and incubated for 8 hours of photoperiod using cool- white fluorescent tubes with a light intensity of 3,000 lux at 22°C + 2°C.

Results:
The maximum (7.0 ± 0.045) numbers of shoots were developed from the nodal segment inoculated on MS fortified with BAP (4 mg/L) ± 0.1 % polyvinylpyrrolidone (PVP) with shoots of 1.72 ± 0.018 cm height. Auxin BAP at 4 mg/L proved to be effective for bud proliferation and production of multiple shoots. The best and early root induction was achieved on MS + IBA (1–4 mg/L).

Conclusion:
The developed in vitro protocol would be beneficial for the fast multiplication of bharangi plants and help to minimize the burden on supply and demand, so that the huge demand for the drug is fulfilled and also helpful to protect the plant.
Transient polycythemia during diabetic ketoacidosis triggered by dengue fever in a middle-aged woman
Authors: Insiripong Wattana , Insiripong Somchai 
Published: April 2020

Either dengue fever or diabetic ketoacidosis can cause the high hemoglobin concentration due to intravascular volume loss. When both entities were found together as in our case, the hemoglobin concentration could access the strikingly high level until either of them could not contribute it. She was a Thai woman with 46 years of age presenting with fever, fatigue and severe sore throat for a few days. The physical examination showed she had mild dyspnea and oral thrush, the temperature was 36.4 degree Celsius, and her pulse rate was 102/min. Her blood tests showed: Hb 18.3 g%, WBC 9,850/mm3, atypical lymphocyte 10%, platelet 16,000/mm3, MCV 89.2 fl, Dengue NS1 antigen-positive, dengue IgG-positive, IgM-weakly positive, KOH preparation of curd from buccal mucosa-positive for budding yeasts and pseudo-hyphae, blood sugar 442 mg%, triglyceride 578 mg%, Na 122.8 mEq/L, K 6.28 mEq/L, Cl 90.6 mEq/L, CO2 9.2 mEq/L, blood ketone 53.6 mmol/L, lactate 4.5 mmol/L, pH 7.257, pCO2 27.4 mmHg, HCO3 11.9 mmo/L, BUN 22.9 mg%, creatinine 0.64 mg%, AST 375 U/L, ALT 224 U/L, alkaline phosphatase 151 U/L. She was diagnosed as having diabetes with diabetic ketoacidosis, dengue fever and polycythemia. She was immediately treated with intravenous fluid therapy to correct the metabolic acidosis, electrolyte imbalance and dehydration, insulin for hyperglycemia, clotrimazole for oral thrush and platelet transfusion. Her high hemoglobin level was dramatically lowered until became normal within one day of therapy whereas she also recovered from DKA although the platelet was progressively lowered every day. It suggested that transient polycythemia was solely contributed by DKA that was triggered by dengue fever hence DKA from dengue fever should be added in the list of unusual causes of transient polycythemia.
Serological and genotyping study of rare cis-AB01/O01 in the area of Inner Mongolia - with a case report
Authors: Wang Chunhai , Wang Wenmei , Huang Hualiang 
Published: April 2020

The antigen gene of ABO blood group system, called ABO, is located on human chromosome 9, with a total length of 19.5 kb. It is the first blood group system found by human beings.[1] ABO blood group subtypes are formed by ABO genovariation, i.e., gene A variation for A subtype, gene B variation for B subtype and gene O variation for new O alleles. ABO subtypes contain A3, Ax, Ael, Aw, Am, B3, Bx, Bel, Bw, cis-AB, B (A). Generally, an individual with AB blood group has an A allele on one chromosome, with B allele on its paired chromosome. This phenomenon is called trans-AB. However, cis-AB is a unique ABO phenotype that A and B alleles are located on the same chromosome, so that it can be inherited by the next generation.[2] This special mode of inheritance often causes a discrepancy of ABO blood grouping and then reduces the effectiveness and safety of blood transfusion.Therefore, to accurately identify the blood group of cis-AB is a precondition for the safety of blood transfusion.[3] The serological and genotyping analysis on a case of cis-AB patient in our hospital is reported as follows.
Neurotoxicity after hematopoietic stem cell transplant in multiple sclerosis
Authors: Thebault Simon , Lee Hyunwoo , Bose Gauruv , Tessier Daniel , Abdoli Mohammad , Bowman Marjorie , Berard Jason , Walker Lisa , Rush Carolina A. , MacLean Heather , Booth Ronald A. , Narayanan Sridar , Arnold Douglas L. , Tabard‐Cossa Vincent , Atkins Harold L. , Bar‐Or Amit , Freedman Mark S. 
Published: April 2020

AbstractObjectiveAccelerated brain volume loss has been noted following immunoablative autologous hematopoietic stem cell transplantation (IAHSCT) for multiple sclerosis. As with other MS treatments, this is often interpreted as ‘pseudoatrophy’, related to reduced inflammation. Treatment‐related neurotoxicity may be contributory. We sought objective evidence of post‐IAHSCT toxicity by quantifying levels of Neurofilament Light Chain (sNfL) and Glial Fibrillary Acidic Protein (sGFAP) before and after treatment as markers of neuroaxonal and glial cell damage.MethodsSera were collected from 22 MS patients pre‐ and post‐IAHSCT at 3, 6, 9, and 12 months along with 28 noninflammatory controls. sNfL and sGFAP quantification was performed using the SiMoA single‐molecule assay.ResultsPre‐IAHSCT levels of sNfL and sGFAP were elevated in MS patients compared with controls (geometric mean sNfL 21.8 vs. 6.4 pg/mL, sGFAP 107.4 vs. 50.7 pg/mL, P = 0.0001 for both). Three months after IAHSCT, levels of sNfL and sGFAP increased from baseline by 32.1% and 74.8%, respectively (P = 0.0029 and 0.0004). sNfL increases correlated with total busulfan dose (P = 0.034), EDSS score worsening at 6 months (P = 0.041), and MRI grey matter volume loss at 6 months (P = 0.0023). Subsequent NfL levels reduced to less than baseline (12‐month geometric mean 11.3 pg/mL P = 0.0001) but were still higher than controls (P = 0.0001). sGFAP levels reduced more slowly but at 12 months were approaching baseline levels (130.7 pg/mL).InterpretationThere is direct evidence of transient CNS toxicity immediately after IAHSCT which may be chemotherapy mediated and contributes to transient increases in MRI atrophy.
Near‐optimal time series sampling based on the reducedHessian
Authors: Chen Weifeng , Biegler Lorenz T. 
Published: April 2020

AbstractA model‐based experimental design strategy is developed to select a minimal set of measured points from a time series of experiments. Based on reduced Hessian information embedded within a mixed integer nonlinear program, an optimal time series is determined that leads to well‐fitted models, with ratios of parameter standard deviation to estimated value within acceptable bounds. Demonstrated on three examples, the proposed approach is effective and efficient especially for time‐consuming and expensive measurements.
An Artemisinin‐Derivative–(NHC)Gold(I) Hybrid with Enhanced Cytotoxicity through Inhibition of NRF2 Transcriptional Activity
Authors: Zhang Chen , Fortin Pierre‐Yves , Barnoin Guillaume , Qin Xue , Wang Xing , Fernandez Alvarez Alvaro , Bijani Christian , Maddelein Marie‐Lise , Hemmert Catherine , Cuvillier Olivier , Gornitzka Heinz 
Published: April 2020

AbstractA family of hybrid complexes combining two biologically active motifs, an artemisinin derivative and a cationic bis(NHC)‐gold(I) unit, has been synthesized. One of these complexes, 2 a, has been analyzed by single‐crystal X‐ray diffraction. 2 a shows strong anticancer activities on a large panel of human cancer cell models (prostate, breast, lung, liver, bladder, bone, acute and chronic myeloid leukemias) with GI50 values in the nm range, together with a high selectivity. An original and distinctive mechanism of action, that is, through inhibition of the redox antioxidant NRF2 transcription factor (strongly associated with aggressiveness and resistance to cancer therapies) has been evidenced. 2 a could remarkably sensitize to sorafenib in HepG2 liver cells, in which dysregulated NRF2 signaling is linked to primary and acquired drug resistance. 2 a also inhibited NF‐κB and HIF transcriptional activities, which are also associated with progression and resistance in cancer. Our findings provide evidence that hybrid (NHC)gold(I) compounds represent a new class of organometallic hybrid molecules that may yield new therapeutic agents.
Facile Electrochemical Synthesis of Nanoscale (TiNbTaZrHf)C High‐Entropy Carbide Powder
Authors: Sure Jagadeesh , Sri Maha Vishnu D. , Kim Hyun‐Kyung , Schwandt Carsten 
Published: April 2020

AbstractHigh‐entropy alloys and compounds are becoming an important class of new materials due to their outstanding refractory and high‐temperature properties. However, preparation in bulk quantities and in powder form via classical metallurgical methods is challenging. Here, we report the first synthesis of an ultra‐high‐temperature high‐entropy carbide, (TiNbTaZrHf)C, via a facile electrochemical process. In this, a mixture of the individual metal oxides and graphite is deoxidised in a melt of CaCl2 at a temperature of only 1173 K. The (TiNbTaZrHf)C prepared is single‐phase fcc and has a powdery morphology with a particle‐size range of 15–80 nm. Such materials are in demand for modern additive manufacturing techniques, while preliminary tests have also indicated a possible application in supercapacitors. The successful synthesis of (TiNbTaZrHf)C powder may now guide the way towards establishing the electrochemical route for the preparation of many other entropy‐stabilised materials.
Information Coding in a Reconfigurable DNA Origami Domino Array
Authors: Fan Sisi , Wang Dongfang , Cheng Jin , Liu Yan , Luo Tao , Cui Daxiang , Ke Yonggang , Song Jie 
Published: April 2020

AbstractDNA nanostructures with programmable nanoscale patterns has been achieved in the past decades, and molecular information coding (MIC) on those designed nanostructures has gained increasing attention for information security. However, achieving steganography and cryptography synchronously on DNA nanostructures remains a challenge. Herein, we demonstrated MIC in a reconfigurable DNA origami domino array (DODA), which can reconfigure intrinsic patterns but keep the DODA outline the same for steganography. When a set of keys (DNA strands) are added, the cryptographic data can be translated into visible patterns within DODA. More complex cryptography with the ASCII code within a programmable 6×6 lattice is demonstrated to demosntrate the versatility of MIC in the DODA. Furthermore, an anti‐counterfeiting approach based on conformational transformation‐mediated toehold strand displacement reaction is designed to protect MIC from decoding and falsification.
Optical fog‐assisted cyber‐physical system for intelligent surveillance in the education system
Authors: Singh Kiran Deep , Sood Sandeep K. 
Published: April 2020

AbstractNowadays, surveillance systems are becoming popular for safety and security purposes in many sectors like government organizations, private institutes, hospitals, schools, residential societies, etc. The role of intelligent surveillance in the education system fulfills diverse requirements such as general surveillance of the campus, recording of a lecture, monitoring behavior of student/teacher, tracking, students, administrative surveillance and security surveillance, etc. In the present educational system, the traditional cloud/fog‐based cyber‐physical system (CPS) and surveillance system enable remote monitoring, machine learning, analytics, and early decision making for real‐time tasks. The existing solutions are inadequate to fulfill the requirements of ultra‐low delay and minimum energy consumption of the surveillance devices. In this paper, an optical fog‐assisted CPS is presented for intelligent surveillance in the education system that uses optical resources at the optical fog layer as fog devices for facilitating early decisions or actions with no delay, minimum energy consumption, and optimum usage of the bandwidth. The proposed system provides (a) a scalable smart OpticalFog node in the middleware of cloud and surveillance devices and (b) service assurance to various CPS‐based applications through the Fog manager. An optimum placement algorithm is proposed for the Fog manager to place the CPS‐based tasks on the nearby optical fog device. The iFogSim toolkit is used for evaluating the proposed algorithm in realizing CPS‐based surveillance in the education scenario. It can be observed from the results that delay in the traditional scenarios for different configurations of surveilled blocks are varying from 210 to 7,867 ms. However, the proposed system has provided ultra‐low delay in the range of 7.6–8.93 ms. Similarly, the energy consumption of surveillance cameras is significantly reduced. Moreover, network usage by the proposed framework is also less than the traditional system. Hence, results show the effectiveness of the proposed framework.
A PNA‐DNA2 Triple‐Helix Molecular Switch‐Based Colorimetric Sensor for Sensitive and Specific Detection of microRNAs from Cancer Cells
Authors: Xu Mengjia , Fu Pan , Xing Shu , Zhao Yang , Zhao Chao 
Published: April 2020

AbstractPeptide nucleic acids (PNAs), the synthetic DNA mimics that can bind to oligonucleotides to form duplexes, triplexes, and quadruplexes, could be advantageous as probes for nucleic acid sequences owing to their unique physicochemical and biochemical properties. We have found that a homopurine PNA strand could bind to two homopyrimidine DNA strands to form a PNA‐DNA2 triplex. Moreover, the cyanine dye DiSC2(5) could bind with high affinity to this triplex and cause a noticeable color change. On the basis of this phenomenon, we have designed a label‐free colorimetric sensing platform for miRNAs from cancer cells by using a PNA‐DNA2 triple‐helix molecular switch (THMS) and DiSC2(5). This sensing platform can detect miRNA‐21 specifically with a detection limit of 0.18 nM, which is comparable to that of the THMS‐mediated fluorescence sensing platform. Moreover, this colorimetric platform does not involve any chemical modification or enzymatic signal amplification, which boosts its applicability and availability at the point of care in resource‐limited settings. The universality of this approach can be simply achieved by altering the sequences of the probe DNA for specific targets.