bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 pandemisinde görev yapan sağlık çalışanlarında anksiyete belirtileri ve uykusuzluk
Authors: ATAÇ Ömer , SEZEROL Mehmet Akif , TAŞÇI Yusuf , HAYRAN Osman 
Published: November 2020

Amaç: Bu çalışmada, COVID-19 pandemisi döneminde görev yapan sağlık çalışanlarının anksiyete ve uykusuzluk düzeyleri incelenmiştir. Yöntem: Kesitsel türde olan bu çalışmanın evrenini bir ilçe sağlık müdürlüğünde görevli sağlık çalışanları oluşturmaktadır. Veriler yüz yüze görüşme yoluyla uygulanan anket formlarıyla toplanmıştır. Üç bölümden oluşan anket formunda katılımcıların tanımlayıcı özelliklerine yönelik sorular, Yaygın Anksiyete Bozukluğu-7 Testi ve Uykusuzluk Şiddeti İndeksi yer almaktadır. Bulgular: Çalışma evreninin %85.6’sına (n=149) ulaşılmıştır. Yaş ortalaması 35.70±9.27 olup %71.5’i kadındır. %82.3’ü üniversite mezunu, %10.8’i hekimdir. Halk sağlığı hizmetleri biriminde görev yapanlar tüm personelin %31.5’ini; ağız ve diş sağlığı merkezinde görev yapanlar ise %24.6’sını oluşturmaktadır. Katılımcıların %33.1’i pandemi döneminde de aynı görevine devam ederken, %27.7’si vaka filyasyonu, %16.9’u ise Halk Sağlığı Yönetim Sistemi işlemlerinde görev yapmaktadır. COVID-19 tanısı alanların oranı %19.2’dir. Çalışanların %52.3’ünde yaygın anksiyete bozukluğu, %53.1’inde uykusuzluk mevcuttur. Hem yaygın anksiyete bozukluğu hem de uykusuzluk olanların oranı %36.9’dur. Öğrenim durumuna göre, lise mezunları anksiyete bozukluğu ve uykusuzluğun en az olduğu gruptur (sırasıyla p=0.029; p=0.031). Sonuç: Pandemiyle mücadelede ön safta görev yapan ilçe sağlık müdürlüğü personelinde yaygın anksiyete bozukluğu ve uykusuzluk sık görülmektedir. Çalışanların korunması pandemi döneminde alınması gereken önlemlerin önemli bir parçasıdır. Hem çalışanların iyilik halinin sürdürülmesi hem de sağlık hizmetlerinin yürütülmesinde yeterli insan kaynağını sağlayabilmek için sağlık çalışanlarının ruh sağlığı sorunlarına önem verilmelidir. Bu sayede hem çalışanların sağlıkları korunacak hem de topluma sundukları sağlık hizmeti aksamadan devam edecektir.
Sensory assessment of grape polyphenolic fractions: an insight into the effects of anthocyanins on in-mouth perceptions
Authors: Paissoni Maria Alessandra , Waffo-Teguo Pierre , Ma Wen , Jourdes Michael , Giacosa Simone , Río Segade Susana , Rolle Luca , Teissedre Pierre-Louis 
Published: November 2020

Anthocyanins are extracted from grape skins during maceration and are responsible for the red colour of wine. Their contribution to in-mouth sensations is mainly related to their interactions with condensed tannins, which are largely responsible for wine astringency and mouthfeel-related features. Recently, the influence of several groups of polyphenols, together with other relevant non-phenolic wine constituents,was investigated in terms of their ability to modify the sensory perception of condensed tannins. The aim of this study was to investigate the influence of three acylation groups of anthocyanins (glucoside, acetylglucoside, and p-coumaroylglucoside) extracted from grape skins on in-mouth related features. An extract of total anthocyanins and their individual fractions were tasted using different sensory approaches (triangle test, check-all-that apply and descriptive analysis) and compared to polyphenols extracted from grape skins and seeds. The investigated sensations were overall astringency and astringency sub-qualities, which were divided into two groups: sensation during tasting (in-mouth, particulates) and sensation after expectoration (surface smoothness). Bitterness was also studied. Anthocyanin fractions were added to skin and seed extracts and tasted as mixtures to find out if anthocyanins modify in-mouth perception. Although the anthocyanin fractions showed a low sensory impact, total anthocyanins and the glucoside fraction were perceived at the concentration ranges found in wines (400 mg/L), and they were found to influence astringency intensity and soft astringency sub-qualities, such as “velvety” and “chalky”. The addition of glucoside anthocyanin (400 mg/L) to skin and seed extract (1000 mg/L) modified in-mouth perception; in particular, seed extract was perceived as being more astringent and was characterised by harsher astringency sub-qualities (surface smoothness and particulates). In contrast, the addition of glucoside anthocyanin to the skin extract led to lower surface smoothness, although the intensity of overall astringency was unchanged. These results confirm that the presence of anthocyanins can modify the perception of in-mouth sensations and interact to different extents with other polyphenols, thus leading to the modification of the intensity of astringency and its sub-qualities.
JACIII Distinguished Editor &
Outstanding Reviewer Awards 2020
Authors:   Editorial Office
Published: November 2020

The JACIII Distinguished Editor and Outstanding Reviewer Awards were established for the purpose to honor and editors who have made a significant contribution to the growth of the JACIII in 2018 and to acknowledge reviewers who have made a significant contribution to reviewing in 2019. We express our deepest gratitude for their professional work, which we believe conductive to development of not only the JACIII but also scientific research.

JACIII DISTINGUISHED EDITOR AWARD 2020
Fei Yan (Changchun University of Science and Technology, China) Guohun Zhu (Guilin University of Electronic Technology, China) Junzo Watada (Waseda University, Japan) Yoshiyuki Yabuuchi (Shimonoseki City University, Japan)

JACIII OUTSTANDING REVIEWER AWARD 2020
Fei Yan (Changchun University of Science and Technology, China) Yasufumi Takama (Tokyo Metropolitan University, Japan) Luefeng Chen (China University of Geosciences, China) Xin Chen (China University of Geosciences, China) Tomomi Hashimoto (Saitama Institute of Technology, Japan) Hiroyuki Masuta (Toyama Prefectural University, Japan) Yasutake Takahashi (Fukui University, Japan)
KOMPARASI METODE DWT DAN SVD UNTUK MENGUKUR KUALITAS CITRA STEGANOGRAFI
Authors: Darwis Dedi , Pasaribu A. Ferico Octaviansyah 
Published: November 2020

<em>Keamanan data saat ini merupakan hal yang sangat penting diera digital karena komunikasi harus bersifat rahasia dan aman. Salah satu cara untuk berkomunikasi secara digital adalah steganografi yaitu pengembangan dari kriptografi, teknik ini memiliki cara menyembunyikan data dan informasi pada media lainnya misalkan seperti citra digital karena media ini sering digunakan dalam pertukaran informasi dan data. Algoritma steganografi yang digunakan pada penelitian ini adalah Discrete Wavelet Transform (DWT) dan Singular Value Decomposition (SVD) kedua metode ini merupakan bagian dari steganografi yang sama-sama memanfaatkan domain transform pada pengolahan citra digital dan memiliki kecepatan yang tinggi dalam penyisipan pesan rahasia ke suatu gambar. Masalah yang selama ini terjadi pada steganografi adalah kualitas stego image yang dihasilkan pada steganografi mengalami perubahan pada kualitas citra, sehingga perbedaan antara cover image dan stego image akan sangat terlihat. Penerapan metode DWT dan SVD pada penelitian ini diimplementasikan dengan bahasa pemrograman Python 2. Berdasarkan hasil pengujian yang dilakukan metode DWT dapat menghasilkan kualitas citra pada stego image yang lebih baik jika dibandingkan metode SVD yaitu menghasilkan nilai MSE nilai rata-rata 0,0046 db. Hasil perhitungan nilai PSNR juga membuktikan bahwa metode DWT menghasilkan kualitas citra lebih baik dari dari metode SVD yaitu menghasilkan nilai rata-rata 63,47 db.</em>
The Concept of Istitā‘ah Al-Bā’ah in Marriage
Authors: Hidayat Taufiq , Azahari Raihanah 
Published: November 2020

Islam has to law of sharia a marriage between men and women in order to build a family that is sakinah, mawaddah and rahmah. In order to achieve the goal of marriage, Islam has set a requirement for married couples to have several abilities to marry which is termed as istitā'ah al-bā'ah. Practically, there are still many people in marriages understanding the concept of istitā’ah al-bā’ah partially and even not applied it at all. The objective of this study is to examine the concept of istitā’ah al-bā’ah as a requirement in marriage and to explain its types and criteria according to sharia perspective through library research on Fiqh Principle and content analysis of Fiqh books. This study deeply analyses the collective data. This study has successfully found the types and criteria of marriage recommended in marriage, firstly, non-material abilities including an ability to have sex, physical health from dangerous diseases, and age. The second is material ability including an ability to meet the cost of marriage consisting of paying dowry and living. This study contributes to the context of strengthening the ability standards for couples wishing to get married. Therefore, fulfilling the requirements of the abilities to marry is expected to minimize problems in marriage, including minimizing the divorce rate.Islam telah mensyariatkan perkawinan antara laki-laki dan perempuan dengan tujuan membina keluarga yang sakinah, mawaddah dan rahmah. Untuk mewujudkan perkawinan tersebut maka Islam telah menetapkan persyaratan kepada pasangan yang akan menikah untuk memiliki kemampuan menikah terlebih dahulu yang diistilahkan dengan istitā’ah al-bā’ah. Dalam praktiknya banyak yang memahami konsep istitā’ah al-bā’ah secara parsial atau bahkan perkawinan yang tidak dilandasi konsep istitā’ah al-bā’ah. Kajian ini bertujuan untuk mengkaji konsep istitā’ah al-bā’ah sebagai sebuah persyaratan dalam perkawinan serta menjelaskan jenis dan kriterianya menurut perspektif syariah. Melalui kajian literatur (library research) terhadap kaidah fikih dan analisis kandungan terhadap kitab-kitab fikih. Analisis dilakukan secara mendalam terhadap data yang telah terkumpul. Kajian ini berhasil menemukan jenis-jenis dan kriteria kemampuan menikah yang dianjurkan dalam Islam, yaitu: pertama, kemampuan non material yang meliputi kemampuan melakukan hubungan kelamin, kesehatan fisik dari penyakit-penyakit yang berbahaya dan cukup umur. Kedua ialah kemampuan material yaitu kemampuan memenuhi biaya nikah yang terdiri dari kemampuan membayar mahar dan nafkah. Kajian ini berkontribusi dalam konteks penguatan standar kemampuan bagi pasangan yang ingin melangsungkan perkawinan. Sehingga dengan prasyarat kemampuan menikah tersebut, diharapkan dapat meminimalisir problem dalam perkawinan, termasuk meminimalisir angka perceraian.
MYOD1 Inhibits Avian Adipocyte Differentiation via miRNA-206/KLF4 Axis
Authors: Wang Zheng , Zhao Qiang-Sen , Li Xiao-Qin , Yin Zhong-Tao , Chen Si-Rui , Wu Sen , Yang Ning , hou Zhuo-cheng 
Published: November 2020

Abstract
Background: A considerable number of muscle development-related genes were differentially expressed in the early stage of avian adipocyte differentiation. However, the functions of them in adipocyte differentiation remain largely known. In this study, the myoblast determination protein 1 (MYOD1) was selected as a representative of muscle development and we investigated its expression, function and regulation in avian adipocyte differentiation.Results: The expression of MYOD1 decreased significantly in the early stage of avian adipocyte differentiation. CRISPR/CAS9-mediated deletion of MYOD1 induced adipocyte differentiation, whereas over-expression of MYOD1 inhibited adipogenesis. mRNA-seq showed that MYOD1 could perturb the lipid biosynthetic process during differentiation. Mechanistically, MYOD1 directly up-regulates the miR-206 expression by binding upstream 1200 bp region, and over-expression of miR-206 also inhibits adipogenesis. Furthermore, MYOD1 affected the expression of endogenous miR-206 and its target gene Kruppel Like Factor 4 (KLF4), which is an important activator of adipogenesis. Accordingly, the inhibition of miR-206 or over-expression of KLF4 could counteract the inhibitory effect of MYOD1 on adipocyte differentiation. Conclusions: These findings suggest that MYOD1 inhibited adipocyte differentiation by up-regulating miR-206 to suppress the KLF4 expression. Collectively, these findings identify a novel function of MYOD1 in adipocyte differentiation, suggesting a potential role in body-fat distribution regulation.
Fluid Nanocarrier for Insulin for Noninvasive Treatment of Diabetes Mellitus
Authors: Alkrad Jamal Alyoussef 
Published: November 2020

Abstract
Background A real solution for diabetics to end their suffering with injection and the consequences of poor patient compliance based on the understanding how the body releases insulin as well as the nature of insulin is an argent demand. In this study a novel management strategy was developed using fluid nanocarrier as well as a solution of insulin to treat this problem. The developed nanocarrier is a microemulsion (ME) containing insulin. The transdermal flux of insulin was estimated through rat’s skin using a Franz diffusion cell. Moreover, the efficacy of the treatments was assessed orally and transdermally in rats. Results Based on the rheological properties and droplets size results the formulated fluids were microemulsions. Also, a flux of insulin as high as 1.77±0.22 iu.cm-2.h-1 through rat’s epidermis could be achieved. The short term monitoring of blood sugar level after transdermal application exhibited a slight decrease. On the other hand, the frequent application could achieve a satisfied decline. However, the rapid and significant reduction of the blood sugar level after oral application was surprised. The X-raying of the GI after oral application of the preparation showed high illumination in the lower part of the esophagus and upper part of the stomach. Conclusion This study reveals high potential esophageal absorption using fluid dosage forms. It must be taken in consideration as sublingual and intranasal application. The developed nanofluid can control the blood sugar level orally or in combination with transdermal application and help the diabetics to adhere their therapeutic course.
Bayesian Spatial Quantile Interval Model with Application to Childhood Malnutrition in Ethiopia
Authors: Shebeshi Abdu , Asfaw Zeytu 
Published: November 2020

Abstract
Background: The national prevalence of stunting and wasting in Ethiopia is still very high and it is the most common causes of morbidity and mortality among less than five years old children. The aim of the current study was to investigate the determinant of stunting and wasting in Ethiopia. Methods: Malnutrition data-sets collected through EDHS 2016 were analyzed by Bayesian spatial quantile interval regression models using R- INLA package. Results: The present study found that child sex, child age, mother's education, mother's age, source of drinking water, mother's BMI , wealth index, region, residence, cooking fuel and toilet facility were significantly associated with childhood malnutrition (stunting and wasting). Furthermore, these findings imply that a multisectorial and multidimensional approach is important to address malnutrition in Ethiopia. Conclusion: The education sector should promote reduction of gender barriers that contribute to childhood malnutrition and also the health sector should encourage positive behaviors toward childcare and other feeding practices. Moreover, both governmental and non-governmental potential stakeholders should pay attention on the significant factors identified through the current study so that stunting and wasting in Ethiopia minimized optimally.
WITHDRAWN: TNF-α Increase the Risk of Bleeding in Patients after CAR-T Cell Therapy: A Bleeding Model Based on a Real-World Study of Chinese Car-T Working Party
Authors: Qi Jiaqian , Lv Xin , Chen Jia , Wang Hong , Chu Tiantian , Tang Yaqiong , Pan Tingting , Zhou Meng , Cai Chengsen , Ren Yuan , Liu Yuejun , Fan Yi , Shen Wenhong , Ma Xiao , Qiu Huiying , Tang Xiaowen , Fu Chengcheng , Wu Depei , Han Yue 
Published: November 2020

Abstract
Backgroud: Chimeric antigen receptor (CAR) T-cell therapy has shown excellent clinical efficacy in patients with hematologic malignancies. However, severe bleeding after this treatment is a life-threatening complication for most patients. Objectives: This study evaluated the risk factors associated with bleeding in CAR-T treatment and developed a predictive model for this complication. Methods: We conducted a real-world study incorporating data from 400 patients with hematologic malignancies treated with CAR-T between November 1, 2015 and September 1, 2019. Also 39 patients from another hospital were selected for external validation. Results: Patients with severe bleeding (hazard ratio [HR] 13.04, 95% confidence interval [CI] 5.82-29.18; p<0.001) had a higher risk of death after CAR-T. Stage III and IV cytokine release syndrome (CRS) (odds ratio [OR] 6.07, 95% CI 2.35-16.76; p<0.001) and higher tumor necrosis factor-α (TNF-α) levels (OR 4.00, 95% CI 1.53-11.35; p<0.001) were independent factors of bleeding in patients after CAR-T treatment. The predictive model developed by Lasso regression, which selected factors such as CRS period, transfusion volume, platelet percentage, platelet count, thrombinogen time, interleukin 6 and TNF-α levels, and showed Nomogram, yielded excellent agreement (C-statistics=0.905) with the calibration curve, which improved clinical benefit with respect to established bleeding scores such as outpatient bleeding risk index (MOBRI). External validation was performed using 39 patients from another hospital with an AUC of 0.700. Conclusions: Patients with severe bleeding after Car-T therapy had increased the risk of death. A cross-validated bleeding risk score based on CRS stages and TNF-α level show significant prognostic value in patients undergoing Car-T treatment.
Prevalence of Hyperuricemia and Its Correlations With Other Diseases in The Pearl River Delta, Guangdong Province, China
Authors: Liu Weiqi , Wang Shaoling , Liu Weiling , Tong Huichun , Yuan Jianmin , Zou Zhenning , Liu Jianwen , Yang Donghai , Xie Zhongxing 
Published: November 2020

Abstract
Background: Hyperuricemia (HUA) has become the most common and serious public health problem worldwide. In China, the prevalence of HUA in the Pearl River Delta (PRD) region of Guangdong Province has not been extensively investigated. Therefore, this study investigated the prevalence of HUA and its related factors among people aged 20–99 years in nine cities in the PRD.Methods: We selected 6491 health check participants from 9 cities in the PRD and collected participants’ anthropometric and biochemical test results for a cross-sectional study. We included 6491 participants and assessed their blood pressure (BP), body mass index (BMI), total cholesterol (TC), triglycerides (TG), glucose (Glu) and serum uric acid (UA) to analyze the regional prevalence of HUA and its related factors. HUA was indicated when fasting serum UA level was > 420 μmol/L in men and > 360 μmol/L in women.Results: Overall prevalence of HUA in our cohort was 34.05%; prevalence was higher in men than in women (41.53% vs 26.14%, P < 0.000). Characteristics associated with HUA were hypertension (odds ratio (OR), 5.506; 95% confidence interval (CI), 4.402–6.889), higher body mass index (BMI; OR: 1.746; 95% CI: 1.560–1.954), age 31–40 years (OR: 0.829; 95% CI: 0.706–0.973), age 61–70 years (OR: 1.434; 95% CI: 1.194–1.722) and age > 71 years (OR: 1.742; 95% CI: 1.397–2.173). In all subjects, serum UA was positively correlated with Glu, TG and TC. After we adjusted for age, BMI and BP, multivariate logistic-regression analysis showed that HUA risk factors were high TC (OR: 1.770; 95% CI: 1.459–2.147) and TG (OR: 1.961; 95% CI: 1.632–2.357) in men; and high Glu (OR: 1.508; 95% CI: 1.084–2.099), TC (OR: 1.341; 95% CI: 1.084–1.660) and TG (OR: 1.680; 95% CI: 1.290–2.187) in women.Conclusion: The prevalence of HUA was relatively high in the PRD of Guangdong Province. Relevant governmental bodies should focus on early diagnosis, early treatment and early intervention.
Potential Drugs Against COVID-19 Revealed by Gene Expression Profile, Molecular Docking and Molecular Dynamic Simulation
Authors: Cava Claudia , Bertoli Gloria , Castiglioni Isabella 
Published: November 2020

Abstract
BackgroundSARS-CoV-2 coronavirus, an emerging Betacoronavirus, is the causative agent of the severe acute respiratory distress syndrome outbreak in 2019 (COVID-19). Currently, there are neither specific and selective antiviral drugs for the treatment nor vaccines to prevent contagion. Here we propose a bioinformatic approach in order to test in silico the efficacy of existing drugs for COVID-19. ResultsIn the first step of our study we identified, through a gene expression analysis, several drugs that could act on the biological pathways altered in COVID-19. In the second step, we performed a docking simulation in order to test the properties of the identified drugs to target the 3CL main protease of SARS-CoV-2. The drugs that showed higher binding affinity are bardoxolone (-8.78 kcal/ mol), Irinotecan (-8.40 kcal/mol) and Pyrotinib (-8.40 kcal/mol). Molecular dynamics simulations were carried out on the three selected drugs to validate the stability and interactions of the complexes. Among other promising drugs we found also AZD-8055, Olaparib, Tyrphostin AG 879, Topotecan Hydrochloride, MP-412, S-222611, Allitinib, 7-Ethyl-10-Hydroxy-Camptothecin, and Falnidamol. ConclusionsWe suggested some drugs that could efficient in COVID-19. However further studies are suggested to confirm the affinity of these drugs with 3CL main protease of SARS-CoV-2.
DUOX2 is a Generator of ROS in the Ovary and a Potential Mediator of Ovulation
Authors: Yerushalmi Gil M , Yung Yuval , Dayan Oranit Saiagh , Maman Ettie , Avraham Sarit , Kedem Alon , Hourvitz Ariel 
Published: November 2020

Abstract
Background: Ovulation is triggered by the preovulatory surge of the pituitary luteinizing hormone (LH). LH/hCG induction of reactive oxygen species (ROS) is required for successful ovulation. H2O2, one of ROS species, was shown to fully mimic the effect of LH/hCG in mice ovulation. However, the molecular process that generates H2O2 in the ovary during ovulation remains largely unknown. DUOX2, a member of the NOX/DUOX family of NADPH oxidase, is capable of generating H2O2. Results: Using global transcriptome RNAseq, we identified that DUOX2 is one of the transcripts that was markedly upregulated in granulosa cells during ovulation. Treatment with human chorionic gonadotropin (hCG), an ovulatory trigger, significantly increases the expression of DUOX2 mRNA and protein in human GCs both in vivo and in vitro. hCG-induced up-regulation of DUOX2 is mediated by the cAMP-PKA and the PKC pathway. A functional test reveals that DUOX2 chemical inhibitor, Diphenyleneiodonium (DPI), an NADPH oxidase inhibitor, decreased H2O2 levels in MGCs (Mural Granulosa Cells) treated with hCG. The inhibition of H2O2 by DPI suggests that DUOX2 activity is required for hCG-induced elevation of extracellular H2O2 in MGCs. In vivo treatment of mice with DPI significantly decreases the number of ovulated oocytes and markedly attenuates the expression of key ovulatory genes. These results support the putative role of DUOX2 in ovulation. Conclusions: DUOX2 is a ROS generator during the ovulatory process and is involved in the LH/hCG-induced signaling cascades leading to ovulation. Treatment with DUOX2 inhibitors may affect late folliculogenesis and ovulation and thus may serve for fertility control.