bluuebunny/crossref_metadata_2025_split huggingface dataset:
DEPÓSITOS DE QUARTZO AMETISTA EM MINAS GERAIS
Authors: Dias Coralie H. , Chaves Mario L. S. C. , Figueiredo e Silva Rosaline C. 
Published: June 2020

Em Minas Gerais, o quartzo ametista ocorre em diferentes ambientes geológicos de formação. O presente trabalho apresenta uma revisão do conhecimento acerca destas ocorrências e depósitos. Ametistas em cavidades de basaltos se restringem no Estado à região do Triângulo Mineiro. As cavidades preenchidas são presentes na porção superior do nível central de derrames, contendo, além de quartzo, minerais tipicamente formados em baixas temperaturas como argilominerais e calcita. Os depósitos em veios hidrotermais relacionam-se principalmente ao contexto geológico da Serra do Espinhaço e adjacências a leste e possuem provável idade Brasiliana, representando os maiores volumes em termos de produção e pesquisas relacionadas. Nestes, a ametista associa-se principalmente a quartzo hialino ou leitoso e óxidos de ferro. Em pegmatitos, a ametista não é muito comum, embora existam informações de ocorrências próximas a Teóﬁlo Otoni, além da ocorrência estudada em Pancas (ES). Estas situam-se no contexto da Província Pegmatítica Oriental do Brasil, relacionadas a pegmatitos não zonados e pouco diferenciados, contendo quartzo, feldspato e muscovita, além de apatita, crisoberilo e água-marinha.
Palavras-Chave: Ametista, Depósitos Minerais, Minas Gerais.
RELAÇÃO HIDRÁULICA ENTRE O COMPLEXO BELO HORIZONTE E O GRUPO BAMBUÍ NA PORÇÃO SUL DA APA CARSTE DE LAGOA SANTA, MG
Authors: Andrade Isabella B. , Barbosa Jéssica A. , Ribeiro Carolina G. , Paula Rodrigo S. , Velasquez Leila N. M. 
Published: June 2020

A área desse estudo situa-se ao norte da cidade de Belo Horizonte, Minas Gerais, possui 432 km² e intersecciona parcialmente a porção sul da Área de Proteção Ambiental Federal (APA) Carste de Lagoa Santa. A porção basal é geologicamente caracterizada por granodioritos, granitos e gnaisses que deﬁnem as rochas do Complexo Belo Horizonte. Sobreposto a essa unidade por contato tectônico, estão as coberturas neoproterozoicas do Grupo Bambuí, que dá base para o topo constituam-se, pela Fm. Sete Lagoas, composta por metacalcários, e Fm. Serra de Santa Helena, constituída por metapelitos foliados. Lineamentos fotointerpretados associados com estruturas mensuradas em campo e dados hidráulicos de poços tubulares foram utilizados para a determinação do ﬂuxo subterrâneo entre as rochas do Complexo Belo Horizonte e a Formação Sete Lagoas. A partir dos dados de capacidade especíﬁca obteve-se que a direção NE é tita como preferencial para transferência de ﬂuxo d'água das fraturas do embasamento cristalino para as rochas supracrustais do Grupo Bambuí, de onde o ﬂuxo segue preferencialmente na direção EW. Entretanto, os dados hidráulicos de produtividade levantados mostram que as faixas produtivas nas rochas carbonáticas se orientam preferencialmente nas direções N60-90E e N60-90W.
Palavras-Chave: Apa carste de lagoa santa; hidrogeologia; produtividade poços tubulares
Augmented cAMP Signaling by Co-Administration of Resvera-trol and Curcumin: A Cellular Biosensor Kinetic Assessment
Authors: SAFAVIFAR Farnaz , SAADAT Farshid , JALALI Seyedeh Zohreh , KHORAMIZADEH Mohammad Reza 
Published: June 2020

Background: Curcumin and resveratrol are two polyphenolic compounds extensively investigated for their medicinal effects on inflammatory signaling. However, there is a paucity of information on the Adenosine-3’, 5’-cyclic monophosphate (cAMP) kinetics following administration of curcumin and resveratrol in biological systems. In this study, kinetic modulation of cAMP as a target detection messenger in pro-inflammatory pathways was assessed by co-administration of curcumin and resveratrol using a cellular sensor model.
Methods: To evaluate their putative activity, curcumin and resveratrol compounds were administered alone or in combination on the media culture of cAMP EPAC (exchange protein directly activated by cAMP) bioluminescence resonance energy transfer (BRET) biosensor. The study was performed at the following two centers at Tehran University of Medical Sciences (TUMS): 1- Biotechnology Research Center, and, 2- Endocrinology and Metabolism Research Institute (EMRI) in 2017. Time course kinetic of cAMP response signals were plotted. Forskolin and IBMX were used to stabilize the cAMP signals.
Results: When we treated HEK-293T biosensor cells at 10uM concentration, curcumin and resveratrol upregulated cAMP signaling. Co-administration of resveratrol and curcumin revealed an augmented cAMP level, as compared to treatments with the compounds alone.
Conclusion: Co-administration of curcumin and resveratrol leverage cAMP kinetic response in a time-course manner. The presented methodology can be readily adopted for drug development and novel biopharmaceutical functional analyses.
Assessing Barriers to Implement Birth Kangaroo Care in Kentucky Birthing Hospitals
Authors: Linares Ana Maria , Barbier Denise , Schoeffler Kristina M. , Collins Rebecca L. 
Published: June 2020

IntroductionKentucky continues to have one of the lowest state breastfeeding rates in the country. In 2014, the majority of the birthing hospitals in Kentucky implemented a practice change to the healthcare model known as Birth Kangaroo Care (BKC) as an effort to increase breastfeeding initiation. The goal of this study was to identify current practices and barriers to implementing BKC.MethodsAn evaluation/surveillance study that incorporated an Internet survey to collect information about the practices and policies of BKC in birthing hospitals in Kentucky was completed.FindingsThe response rate was 54% (n= 25). The birthing hospitals responders to the survey (84%) reported that a BKC policy was established after the educational intervention. Data identified two perceived barriers regarding uninterrupted BKC. One barrier was the interruption by family members to hold the newborn, and the second was a delay in BKC for medical evaluations of the baby by staff members.ConclusionBreastfeeding rates after implementation of the BKC policy in Kentucky birthing hospitals showed a statistically significant (p= .02) improvement of “ever breastfed” infants.
Exploring the Feasibility of Utilizing Undergraduate Lactation Education Courses as a Vehicle to Prepare the Future Healthcare Workforce to Educate and Support Breastfeeding Families in the Community
Authors: Efrat Merav , Boyns David , Rubino Louis 
Published: June 2020

BackgroundMinimal lactation knowledge among healthcare professionals has been linked to low breastfeeding rates. To address this problem, one university integrated into its curriculum a lactation education course which aims to provide students from a variety of healthcare related bachelor programs, with the knowledge and skills needed to educate and support breastfeeding families in the community. The aim of this study was to evaluate the feasibility of utilizing undergraduate lactation education courses as a vehicle to better prepare the future healthcare work force to educate and support breastfeeding families in the community.MethodsA 62-question survey was administered pre and post course completion to students enrolled in four sections of a lactation course over the 2018/2019 academic year (n = 96).ResultsFindings suggest that pre to post course completion students had significant increases in their: lactation knowledge, confidence delivering lactation education, confidence in working with clients in a professional setting and positive attitude towards breastfeeding.ConclusionsGiven the lack of knowledge among healthcare professionals is a significant barrier to optimal breastfeeding rates, this evaluation study provides evidence that integrating lactation education courses into university curriculum may be an effective strategy for improving breastfeeding rates.
Mycobacterium fortuitum Prosthetic Joint Infection After Total Hip Arthroplasty
Authors: Fix William C. , Sheth Neil P. , Braffman Michael N. 
Published: June 2020

Case:
A 57-year-old man presented with a Mycobacterium fortuitum prosthetic joint infection (PJI) after right total hip arthroplasty refractory to the initial revision surgery and cement spacer placement. The patient was subsequently treated with 2-stage total joint arthroplasty revision surgery using an antibiotic-laden spacer customized to include meropenem and delayed reimplantation to allow for prolonged, systemic antimicrobial treatment with multiple antimicrobials, including levofloxacin and linezolid.

Conclusions:
There is little evidence to guide practitioners in the diagnosis and treatment of PJI caused by rare, rapidly growing mycobacteria (RGM) such as M. fortuitum. This case demonstrates a successful strategy for the treatment of RGM PJI.
Trends in Measles Cases in Bayelsa State, Nigeria: A Five-year Review of Case-based Surveillance Data (2014- 2018).
Authors: AWORABHI NENI , Numbere Tamunowari , Balogun Muhammed Shakir , Usman Aisha , Utulu Rowland , Ebere Nkechi , Omubo Wakiente , Stow Jones , Abba Shehu , Olorukooba Abdulhakim 
Published: June 2020

Abstract
Background: Measles is a vaccine preventable, highly transmissible viral infection that affects mostly children under five years. It has been ear marked for elimination and Nigeria adopted the measles elimination strategies of the World Health Organization (WHO) African region to reduce cases and deaths. This study was done to determine trends in measles cases in Bayelsa state, to describe cases in terms of person and place, identify gaps in the case-based surveillance data collection system and identify risk factors for measles infection.Methods: We carried out a secondary data analysis of measles case-based surveillance data for the period of January 2014 to December 2018 obtained in Microsoft Excel from the State Ministry of Health. Cases were defined according to WHO standard case definitions. We calculated frequencies, proportions, estimated odds ratios (OR), 95% confidence intervals (CI) and multivariate analysis.Results: A total of 449 cases of measles were reported. There were 245(54.6%) males and the most affected age group was 1-4 years with 288(64.1%) cases. Of all cases, 289(9.35%) were confirmed and 70 (48.27%) had received at least one dose of measles vaccine. There was an all-year transmission with increased cases in the 4th quarter of the year. Yenegoa local government area had the highest number of cases. Timeliness of specimen reaching the laboratory and the proportion of specimens received at the laboratory with results sent to the national level timely were below WHO recommended 80% respectively. Predictors of measles infection were, age less than 5 years (AOR: 0.57, 95% CI: 0.36-0.91) and residing in an urban area (AOR: 1.55, 95% CI:1.02-2.34).Conclusions: Measles infection occurred all-year round, with children less than 5 years being more affected. Measles case-based surveillance system showed high levels of case investigation with poor data quality and poor but improving indicators. Being less than 5 years was protective of measles while living in urban areas increased risk for infection. We recommended to the state government to prioritize immunization activities in the urban centers, start campaigns by the 4th quarter and continue to support measles surveillance activities and the federal government to strengthen regional laboratory capacities.
Comparison of Inpatient Distribution among Different Medical Alliances in County Region: a Longitudinal Study on a healthcare reform in Rural China
Authors: Ran Yifan , Gao Hongxia , Han Dan , Hou Guilin , Chen Yingchun , Zhang Yan 
Published: June 2020

Abstract
Background: China has launched the medical alliances (MAs) reform to drive the development of primary medical institutions and decrease health inequality in rural areas. Three different types of MAs were built to promote township hospitals in Y County. This study aims to evaluate the actual effect of China’s MAs reform in rural areas on inpatient distribution especially amongst different types of MAs.Methods：We obtain 2008–2015 claims data from the New Cooperative Medical Scheme (NCMS) in Y County, Hubei Province of China. We consider January 2008–December 2010 as the pre-reform period and January 2011–December 2015 as the post-reform period. We use independent sample t-test and single-group interrupted time series analysis (ITSA) to compare the number of inpatients per month in the three MAs, including three county and 10 township hospitals before and after the reform. We use paired t-test and multiple-group ITSA between seven township hospitals within MAs and seven township hospitals outside MAs.Results：The MAs reform in Y County increased the number of inpatients in county and township hospitals within MAs. After the reform, the number of inpatients per month in county hospitals had an upward trend, with a slope of 31.01 person/month (P < 0.000). Approximately 19.99 new inpatients were admitted to township hospitals monthly after the reform (P < 0.000). Furthermore, township hospitals within MAs had a substantial increase in the number of inpatients (10.45 new inpatients monthly) compared with those outside MAs. Conclusion: The MAs reform in Y County significantly improved the capability of medical institutions within MAs. After the reform, township hospitals within MAs had greater development advantages than those outside MAs. However, it also caused further imbalance in the county region, which contained the new health inequality risk.
Influence of cement-augmented pedicle screws with different volumes of polymethylmethacrylate in osteoporotic lumbar vertebrae over the adjacent segments: A 3D finite element analysis
Authors: Guo Hui-zhi , Zhang Shun-cong , Guo Dan-qing , Ma Yan-huai , yuan Kai , Li Yong-xian , Peng Jian-cheng , Li Jing-lan , Liang De , Tang Yong-chao 
Published: June 2020

Abstract
Background: Polymethylmethacrylate (PMMA) is commonly used for cement-augmented pedicle screw instrumentation (CAPSI) to improve the fixation stability and reduce the risk of screw loosening in the osteoporotic thoracolumbar spine. Biomechanical researches have shown that various dose of cement (1-3ml) can be injected to enhance screw stability. To date, there have been no studies on the relationship between adjacent segment degeneration and the volume of PMMA. This study aimed to explore the influence of CAPSI with different volumes of PMMA in osteoporotic lumbar vertebrae over adjacent segments by using finite element analysis.Methods: Seven different finite element models were reconstructed and simulated under different loading conditions, including (1) an intact model, (2) three single-level CAPSI models with different volumes of PMMA (1, 1.73, and 2.5 ml), and (3) three double-level CAPSI models with different volumes of PMMA (1, 1.73, and 2.5 ml). To improve the accuracy of the finite element analysis, the models of the injectable pedicle screw and bone cement were created by using a three-dimensional scanning machine and the CAPSI patient’s CT data, respectively. The range of motion (ROM), the stress of intervertebral discs, and the stress of facet in the adjacent segment were comparatively analyzed among the different models.Results: The ROMs of the different segments were compared with experimental data, with good agreement under the different load conditions. Compared with the intact model, the ROM, disc stresses, and facet stress in adjacent segments were found to be higher in the six operative models. Otherwise, with a larger volume of PMMA injected, the ROM, disc stresses, and facet stress slightly increased at the adjacent segment. However, the differences among the augmented models were insignificant for all loading cases.Conclusions: CAPSI could increase the incidence of disk degeneration in the adjacent segment, while within a certain range, different volumes of PMMA provided an approximate impact over the adjacent segment degeneration.
Reduced polyfunctional T cells and increased cellular activation markers in adult allergy patients reporting adverse reactions to food
Authors: Sonnet Friederike , Namork Ellen , Stylianou Eva , Gaare-Olstad Ingvild , Huse Kanutte , Andorf Sandra , Mjaaland Siri , Dirven Hubert , Nygaard Unni 
Published: June 2020

Abstract
Background: The underlying cellular mechanisms causing adverse reactions to food are complex and still not fullyunderstood. Therefore, in this study we aimed to identify functional and/or phenotypical immune cell signaturescharacteristic for adult patients reporting adverse reactions to food.By mass cytometry, we performed high-dimensional profiling of peripheral blood mononuclear cells (PBMC) fromadult patients reporting adverse reactions to food and healthy controls. The patients were grouped according to sIgE-positive or sIgE-negative serology to common food and inhalant allergens. Two broad antibody panels were used,allowing determination of major immune cell populations in PBMC, as well as activation status, proliferation status,and cytokine expression patterns after PMA/ionomycin-stimulation on a single cell level.Results: By use of data-driven algorithms, several cell populations were identified showing significantly differentmarker expression between the groups.Most striking was an impaired frequency and function of polyfunctional CD4+ and CD8+ T cells in patients reportingadverse reactions to food compared to the controls. Further, subpopulations of monocytes, T cells, and B cells hadincreased expression of functional markers such as CD371, CD69, CD25, CD28, and/or HLA-DR as well asdecreased expression of CD23 in the patients. Most of the differing cell subpopulations were similarly altered in thetwo subgroups of patients.Conclusion: Our results suggest common immune cell features for both patient subgroups reporting adversereactions to food, and provide a basis for further studies on mechanistic and diagnostic biomarker studies in foodallergy.
WEARCON: Wearable home monitoring in children with asthma reveals a strong association with hospital based assessment of asthma control.
Authors: Kamp Mattienne R van der , Klaver Emilie C , Thio Bernard J , Driessen Jean MM , de Jongh Franciscus HC , Tabak Monique , Palen Job van der , Hermens Hermie J 
Published: June 2020

Abstract
Background: Asthma is one of the most common chronic diseases in childhood. Regular follow-up of physiological parameters in the home setting, in relation to asthma symptoms, can provide complementary quantitative insights into the dynamics of the asthma status. Despite considerable interest in asthma home-monitoring in children, there is a paucity of scientific evidence, especially on multi-parameter monitoring approaches. Therefore, the aim of this study is to investigate whether asthma control can be accurately assessed in the home situation by combining parameters from respiratory physiology sensors.Methods: Sixty asthmatic and 30 non-asthmatic children were enrolled in the observational WEARCON-study. Asthma control was assessed according to GINA guidelines by the paediatrician. All children were also evaluated during a 2-week home-monitoring period with wearable devices; a physical activity tracker, a handheld spirometer, smart inhalers, and an ambulatory electrocardiography device to monitor heart and respiratory rate. Multiple logistic regression analysis was used to determine which diagnostic measures were associated asthma control.Results: 24 of the 27 uncontrolled asthmatic children and 29 of the 32 controlled asthmatic children could be accurately identified with this model. The final model showed that a larger variation in pre-exercise lung function (OR=1.34 95%-CI 1.07-1.68), an earlier wake-up-time (OR=1.05 95%-CI 1.01-1.10), more reliever use (OR=1.11 95%-CI 1.03-1.19) and a longer respiratory rate recovery time (OR=1.12 95%-CI 1.05-1.20) were significant contributors to the probability of having uncontrolled asthma.Conclusions: Home-monitoring of physiological parameters correlates with paediatrician assessed asthma control. The constructed multivariate model identifies 88.9% of all uncontrolled asthmatic children, indicating a high potential for monitoring of asthma control. This may allow healthcare professionals to assess asthma control at home.Trial registration: Netherlands Trail Register, NL6087. Registered 14 February 2017, https://www.trialregister.nl/trial/6087
Performance Of The Modified Heart Score In An Asian Population
Authors: Sajeed Shanaz , De Dios Michael , Jun Dan Ong Wei , Punyadasa Amila Clarence 
Published: June 2020

Abstract
INTRODUCTION Chest pain is the most common potentially life threatening presentation to the emergency department (ED). Furthermore, the identification of acute coronary syndrome (ACS) including its risk stratification and subsequent disposition can be challenging. The original HEART score was derived as a predictive tool to risk stratify patients presenting with undifferentiated chest pain (CP) and aid physician decision-making. However, it utilized conventional Troponins as its cardiac biomarker component. Our study aims to assess the utility of the modified HEART score with highly sensitive troponins in an Asian setting with mixed ethnicity to determine if it corroborates the findings of the another recent Chinese study by Chun-Peng MA et al[7]. METHODS Clinical data from 413 patients presenting to the ED for evaluation of chest pain were analyzed. The predictive value of the modified HEART score for determining MACE was then evaluated.RESULTS 49 patients (11.9%) had a MACE: 31 patients (7.5%) underwent PCI, and 1 patient (0.2%) underwent CABG. There were 17 (4.1%) deaths.Three risk groups were elucidated based on MACE. In the low risk group (0-2), there were 72 patients (17.4%), with a MACE rate of 1.4%. In the intermediate risk group (3-5), there were 233 patients (56.4%), with a MACE rate of 5.2%. In the high risk group (6-10), there were 108 patients (26.2%), with a MACE rate of 33.3%. CONCLUSION The modified HEART score is an effective risk stratification tool in an ethnically diverse Asian population. Furthermore, it identifies low risk patients who are candidates for early discharge from a local emergency department.