bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioinformatics Analysis Reveals Centromere Protein K Can Serve as Potential Prognostic Biomarker and Therapeutic Target for Non-small Cell Lung Cancer
Authors: Luo Yimin , Wang Xihua , Li Li , Wang Qun , Hu Yue , He Can , Zhang Mei 
Published: August 2020

Background::
Non-small cell lung carcinoma (NSCLC) accounts for 80% of all lung
cancer cases, which have been a leading cause of morbidity and mortality worldwide. Previous
studies demonstrated that centromere proteins were dysregulated and involved in regulating the
tumorigenesis and development of human cancers. However, the roles of centromere protein
family members in NSCLC remained to be further elucidated.

Objective::
The present study aimed to explore the roles of centromere protein family members in NSCLC.

Method::
GEPIA (http://gepia.cancer-pku.cn/) was used to analyze the target’s expression between normal and human cancers. We
explored the prognostic value of centromere proteins in NSCLC using the Kaplan–Meier plotter (http://kmplot.com). The
protein-protein interaction among centromere proteins were determined using GeneMANIA (http://www.genemania.org).
TISIDB (http://cis.hku.hk/TISIDB) database was used to detect the relationship between centromere proteins expression
and clinical stages, lymphocytes, immunomodulators and chemokines in NSCLC. The DAVID database
(https://david.ncifcrf.gov) was used to detect potential roles of CENPK using its co-expressing genes

Results::
The present study for the first time showed that centromere protein family members including CENPA, CENPF, CENPH,
CENPI, CENPK, CENPM, CENPN, CENPO, CENPQ, CENPU were dysregulated and correlated to the poor prognosis of
patients with LUAD. CENPK showed the greatest correlation with the prognosis of patients with NSCLC. We found that
CENPK was significantly highly expressed in LUAD samples and overexpression of CENPK was remarkably correlated
to the shorter OS and DFS on patients with different stage NSCLC. Of note, this study for the first time showed that
CENPK was significantly correlated to the lymphocytes and immunomodulators using the TISIDB database

Conclusion::
In summary, CENPK can serve as a novel biomarker for the diagnosis of patients
with NSCLC.
Cultural Variations in Public Beliefs about Mental Disorders: A Comparison between Tunisia and Germany
Authors: Angermeyer Matthias C. , Carta Mauro G. , Ghachem Rym , Matschinger Herbert , Millier Aurélie , Refai Tarek , Schomerus Georg , Toumi Mondher 
Published: August 2020

Background:
In recent years there is a growing interest in public beliefs about mental disorders. Numerous representative population-based studies have been conducted around the globe, also in European countries bordering on the Mediterranean Sea. However, relatively little is known about public beliefs in countries in Northern Africa.

Objective:
To fill this gap by comparing public beliefs about mental disorders in Tunisia and Germany, focusing on causal beliefs, help-seeking recommendations and treatment preferences.

Methods:
Representative national population-based surveys have been conducted in Tunisia in 2012 (N = 811) and in Germany in 2011 (N = 1852), using the same interview mode and the same fully structured interview starting with a vignette depicting a person suffering from either schizophrenia or depression.

Results:
In Tunisia, the public was more likely to adopt psychosocial and to reject biogenetic explanations than in Germany. Correspondingly, psychological treatments were more frequently recommended and biological ones more frequently advised against. There was also a strong inclination to share religious beliefs and to recommend seeking religious advice. Tunisians tended much more than Germans to hold moralistic views and to blame the afflicted person for his or her illness. In Tunisia, the public tended less to differentiate between schizophrenia and depression than in Germany.

Conclusion:
Marked differences between Tunisia and Germany exist in public beliefs about the causes of mental disorders and their treatment, which correspond to differences in cultural orientations prevailing in these countries. Mental health professionals need to be sensitive to the particular cultural context in which they operate, in order to be able to reach those they intend to care for.
Migrant Women-experiences from the Mediterranean Region
Authors: La Cascia Caterina , Cossu Giulia , Lindert Jutta , Holzinger Anita , Zreik Thurayya , Ventriglio Antonio , Bhugra Dinesh 
Published: August 2020

Introduction:The phenomenon of migration is characterized and influenced by a number of different variables; and the different stages of journey are related to different levels and types of psychological distress. Women, in particular, are exposed to further specific risks during migration.Aim:To determine the factors that affect the psychological health of migrant women during the different stages of the migration journey.Methods:We provide a narrative review of the literature around the experiences of women during migration process, with a geographical focus on women migrating to the Mediterranean area.Results:Little data is currently available on the burden of mental health disorders for female migrants. Most studies about the mental health status of migrants were not gender-disaggregated or focused specifically on migrant women’s experiences of violence. Sexual and Gender-Based Violence (SGBV) was found to be a common risk factor faced by all the women who leave their native country to migrate to other countries.Conclusion:Despite the importance of the issue and the gender-specific variables related to the experience of migrant women, few studies have looked specifically at psychological variables and mental health status in the female migrant population. It is crucial that future studies are conducted around female migration, violence towards women, and women’s mental health, in order to provide an evidence-base for promoting adequate policies and prevention/treatment programs for women.
Staff Perception of Respect for Human Rights of Users and Organizational Well-being: A Study in Four Different Countries of the Mediterranean Area
Authors: Zgueb Yosra , Preti Antonio , Perra Alessandra , El-Astal Sofian , Aviles Gonzalez Cesar Ivan , Piras Martina , Testa Giorgia , Kirolov Iskren , Tamburini Giorgio , Ouali Uta , Kalcev Goce , Romano Ferdinando , Kovess Viviane , Carta Mauro Giovanni 
Published: August 2020

Background:The perception by mental health service staff of respect for users' rights is a fundamental component of organizational well-being. The objective of this work is to examine how cultural differences and the working context can influence the perception of respect for users' rights in mental health professionals in the Mediterranean area.Methods:An observational survey carried out in four different mental health networks in four countries of the Mediterranean area (Tunisia, North-Macedonia, Italy, Palestine). Each invited participant fulfilled a format on socio-demographic information and coded the Well-Being at Work and Respect Right Questionnaire (WWRR). All data were encrypted and analysed using the Statistical Package for Social Sciences (SPSS) version 20. The Games-Howell post-hoc test was used to assess differences between countries. The Games-Howell test does not assume equal variances and sample sizes. Eta-squared (η2) was used as a measure of effect size in the ANOVA (η2around 0.01, 0.06, and 0.14 are considered small, medium, and large, respectively).Results:The sample included 590 professionals working in the mental health field. The four countries showed statistically significant differences with regards to the quality rights assessment tool. Participants from Italy reported, on average, the highest scores across the questions. There were also differences across the countries about the perception of the impact of available resources on the effectiveness of care (η2 = 0.106).Conclusion:Our findings offer a useful insight into the perception of the quality of mental health services, especially from a users’ rights point of view.
Postpartum Depression in The Arab Region: A Systematic Literature Review
Authors: Ayoub Khubaib , Shaheen Amira , Hajat Shakoor 
Published: August 2020

Background:Postpartum Depression (PPD) is a major public health problem affecting mothers and their babies. However, few studies have investigated the prevalence and risk factors for postpartum depression among Arab mothers. This systematic literature review aims to determine the prevalence of PPD among mothers in Arab countries and identify the main risk factors.Methods:A review of all peer-reviewed journal published studies on PPD and its risk factors among Arab mothers until February 2016. The following data bases were searched; PubMed, Springlink, Science direct, EBSCOhost, and Arabpsychnet.Results:25 studies were included in the review. PPD rates were high in general but prevalences were close to the rates observed in other low and lower-middle-income countries. Twelve studies reported PPD prevalences in the region of 15-25%, 7 studies reported prevalences< 15% and 6 studies reported prevalences<25%. The most important risk factors for PPD were: low income and socioeconomic status, obstetric complications during pregnancy, unwanted pregnancy, ill infant, formula feeding, low social and husband support, marital and in-laws conflicts, stressful life events during pregnancy and personal or family history of depression.Conclusion:Prevalence of PPD is high in most Arab countries, with differences due in part to variations in methods of assessment. This review highlights the problem of PPD and advocates for the adoption of necessary changes in the Arab health systems such as routine screening and efficient referral systems in order to detect and treat this potentially debilitating condition.
Factors Behind Leaving the Job and Rejoining it by the Japanese Dental Hygienist
Authors: Nomura Yoshiaki , Okada Ayako , Yamamoto Yuko , Kakuta Erika , Tomonari Hiroshi , Hosoya Noriyasu , Hanada Nobuhiro , Yoshida Naomi , Takei Noriko 
Published: August 2020

Aim:

To investigate the factors that countermeasure the re-entry of Japanese dental hygienist.

Background:

The number of currently working dental hygienists is not sufficient. About 40% licensed dental hygienist are leaving their professional jobs. Re-entry of the dental hygienist who have left is expected to compensate the unbalance of demand and supply.

Objective:
The purpose of this study was to identify the obstacles faced during re-entry by the dental hygienists and propose the countermeasures for supporting re-entry.

Methods:
The Japan Dental Hygienist Association conducts survey of the Employment Status of Japanese dental hygienist every 5 years since 1981.Questionnaires were distributed for all members of the Japan Dental Hygienists Association. Among the 94 items, following eight specific items were used for analysis: 1. The reason of leaving the job. 2. For how long have you left the job? 3. Willingness to reenter. 4. How do you find your work for re-entry? 5. Is there any obstacle in the reentry? 6. What is the obstacle faced by you during reentry? 7. Do you need lecture course for reentry? 8. What kind of lecture course contents do you want to attend?

Results:
Questioners were distributed among the 16,113 members of Appeases Dental hygienist Association, and out of which 8,780 responded (collection rate:54.5%). By log-linear analysis, the reason behind leaving the job were dissatisfaction with work content and marriage significant in age groups ≤29 and 30-39. Child birth / child rearing was significant in age groups ≤29, 30-39 and 40-49. Payment was significant in 30-39 and 40-49. Child birth / rearing and working hours had the most important impacts on leaving the job and were among the obstacle for reentry. In this study, a number of dental hygienist who leave the job due to child birth / rearing was highest.

Conclusion:
There was a limitation for sampling frame of this study. Workplace improvement including flexible working time may be the most important factors for the reentry of the dental hygienist who had left their jobs previously.Social support system is indispensable to improve women's working environment.
Factors Associated with Suicidal Ideation, and Attempt Among Cancer Patients in Ayder Comprehensive Specialized Hospital: Cross-Sectional, Mekelle, Ethiopia
Authors: Araya Tesfalem , Gidey Weyni 
Published: August 2020

Background:

Cancer patients are at high risk for suicide, particularly, when they are informed about the cancer diagnosis. However, there is a limited study in Ethiopia therefore, assessing suicidal ideation, attempt, and its associated factors are needed for intervention.

Methods:
An institutional-based cross-sectional study was conducted from March to June 2019 at Ayder comprehensive specialized hospital with a total of 297 participants. Suicide module of the World Mental Health (WMH) survey initiative version adopted from the World Health Organization (WHO) and used to assess suicidal ideation and attempt. Binary logistic regression analysis employed to identify factors associated with suicidal ideation and attempt. Odds ratio with 95% CI and P-value <0.05 was applied to identify significantly associated factors.

Results:
The lifetime prevalence of suicidal ideation and the attempt was found to be 27.9% [95%CI (22.3, 31.6)] and 8.4% [95%CI (5.2, 10.3)] respectively. Being female [AOR= 2.23, 95%CI (1.27, 3.92)], stage IV cancer [AOR=2.08, 95%CI(1.47, 3.81)], having depression and anxiety [AOR=2.31, 95%CI(1.24,4.32)], poor social support [AOR=3.70, 95%CI(2.01,6.78)], and level 4 performance status [AOR=3.73, 95%CI(1.71, 8.13)] were the factors associated with lifetime suicidal ideation. While being in level 4, performance status was also significantly associated with suicidal attempt.

Conclusion:
Both suicidal ideation and attempt among cancer patients are high. The suicidal ideation had a statistical association with sex, stage of cancer, having depression and anxiety, social support, and level of performance. Therefore, health education for early screening and treatment for depression and anxiety, and giving social support are crucial for the reduction of suicide.
Process Optimization for Extraction of Phytochemicals from Ficus racemosa: Phytochemical Extraction
Authors: Sharma Basista Rabina , Kumar Vikas , Kumar Satish , Singh Arashdeep , Pinakin Dave Jaydeep 
Published: August 2020

Aim:
The aim of the present study was to establishment of a process for extraction of phytochemical from Ficus racemosa

Background:
Ficus racemosa is an underutilized crop containing numerous phytochemicals having
the potential to play a significant role in food and nutritional security. However, it has lower
consumer acceptability because of its taste and presence of fig wasps. In these situations, extraction
of the phytochemical from this crop is an alternate option for its efficient utilization in any food matrices.

Objective:
The objective of the present study was to optimize the extraction technique for the extraction
of phytochemicals from dried Ficus racemosa powder.

Methods:
Present study shows the method for extraction of phytochemicals from dried Ficus racemosa
powder using different variables, i.e. solid-to-liquid ratio (1:10-1:40), temperature (30-70°C),
time (30-120min) and pH (2.5-6.5).

Result:
Maximum phytochemical activity was observed under optimized conditions, i.e. solid--
to-liquid ratio (1:15), temperature (59.99°C), time (30.01min.) and pH (3.50) with 0.834 desirability.
The optimized extract was analyzed using HPLC-DAD, which confirms the presence of ascorbic
acid, gallic acid, tannic acid, chlorogenic acid, ferulic acid, catechin, and quercetin.

Conclusion:
It is concluded that Ficus racemosa can be successfully utilized for the extraction of phytochemical
Sensitivity Enhancement in the Colorimetric/Spectroscopic Determination of Lysozyme Concentration in Nanomolar Level with Colloidal Citrat e Capped Au@Ag Core-shell Nanoparticles
Authors: Aich Debasish , Mondal Rudra N. , Saha Satyajit , Samanta Pijus K. , Bhunia Amit K. , Kamilya Tapanendu 
Published: August 2020

Background:
Lysozyme level in body fluids is a significant indicator of various diseases.
Cheap and simple colorimetric detection of lysozyme, in biological sample, by gold and silver
nanoparticles is a field of interest of nanoparticle research for more than a decade.

Objective:
We report here an attempt to improve the sensitivity part of the colorimetric lysozyme
detection process by using citrate capped gold-silver core-shell nanoparticles without any functionalization.

Methods:
Performance of gold-silver core-shell nanoparticles in determining of lysozyme concentration
in water is done using colorimetric/spectroscopic technique. Gold nanoparticles, silver nanoparticles
and mixed colloidal suspension of gold and silver nanoparticles, for comparison have
also been studied. Selectivity study has been performed through spectroscopic analysis, red-greenblue
colour component analysis and fractal dimension analysis of the nanoparticles interacted with
several low and high isoelectric point proteins.

Results:
Gold-silver core-shell nanoparticles showed higher sensitivity for a wider range of lysozyme
concentration compared to gold and silver nanoparticles prepared by us or reported in literature.
Gold nanoparticles showed higher sensitivity compared to the core-shell nanoparticles, but
for a narrow concentration range of lysozyme. For silver nanoparticles and the mixed nanoparticle
system, both sensitivity and range of determination of lysozyme concentration were much smaller
compared to the core-shell nanoparticles. Core-shell nanoparticles showed better selectivity compared
to gold nanoparticles in identifying aquatic solution of lysozyme from that of other proteins.

Conclusion:
Gold-silver core-shell nanoparticles have higher sensitivity in determining wide range
of lysozyme concentration in water compared to gold and silver nanoparticles reported in literature.
Biogenic Synthesis of Copper Nanoparticles from Rose (Rosa indica L.) and their Applications in Photocatalytic Degradation of Malachite Green and Carbol Fuchsin Dyes
Authors: Kaur Manmeet , Prajapati Suman , Cholia Samneek , Mann Jaskeet S. , Singh Gurpreet 
Published: August 2020

Background:
In recent years, the green synthesis of nanoparticles has taken a lead role
over the conventional chemical and physical approach due to its non-toxic, cost-effective parameters
and has found its place in various applications.

Objectives:
The major objectives of this study were to synthesise and characterise the copper nanoparticles
using the rose extract at different set of conditions and analyse these nanoparticles as a
source of dye degradation agent under sunlight.

Methods:
Present study was conducted with the aim to synthesize the copper nanoparticle using
the rose petal extract. The components present in the extract act as the reduction and stabilization
agents for the synthesis of CuNPs. The synthesized nanoparticles were characterized by using UVVIS,
FTIR, XRD and SEM analysis. Photocatalytic degradation of two dyes (Malachite Green and
Carbol fuchsin) was analysed using double beam spectroscopic analysis.

Results:
UV-Vis analysis indicated the presence of a peak at around 630 nm. The FT-IR analysis
indicated the involvement of various biomolecules during the synthesis of nanoparticles. The
structure and the conformation were elucidated using XRD and SEM showed the agglomerated
form of the synthesized nanoparticles with the size range of about 60-90 nm. The synthesised copper
nanoparticles were used for the degradation of malachite green and carbol fuchsin dye using
photocatalytic under sunlight irradiation. UV-Vis spectral analysis indicated that synthesised copper
nanoparticle act more effective in degradation of malachite green (around 95%) whereas carbol
fuchsin showed a maximum degradation by 52% therefore suggesting that CuNPs act as an efficient
photocatalyst in dye degradation.

Conclusion:
The results obtained from this study indicate that rose extract has the potential of synthesis
of copper nanoparticles which is non-toxic and convenient approach as compared to physical
and chemical synthesis. These nanoparticles can be effectively employed as dye decolourisation
agents to treat industrial effluent and prevent environmental pollution.
Tabernaemontana divaricata Stem and Latex Proteases as Haemostatic Agent with Temporally Spaced Intense Fibrinogenolytic and Mild Fibrinolytic Activity
Authors: Singh Maheshwari K. , Rao Deepthi. N. , Sathish Bedathur A. , Soundarya Sunku P. , Rajagopalan Anusha , Sukumaran Bindhu O. 
Published: August 2020

Background:
Proteases play a crucial role in the pharmacological properties of latex producing
plants. Some of them exhibited intervention with fibrinogenolysis and/or fibrinolysis, two crucial
wound healing events.

Objective:
To evaluate wound healing potential of crude and partially purified enzyme from Tabernaemontana
divaricata (stem and latex).

Materials and Methods:
Proteolytic activity, clot inducing/dissolving potential, fibrinogen polymerization,
recalcification time, blood clot lysis and Tricine-SDS PAGE for enzyme treated fibrinogen and
human plasma clot were performed.

Results:
Latex PPE exhibited significant proteolytic activity (115.8 ± 0.3 U/ml) compared to that of the
stem (28.78 ± 0.2 U/ml). Enzyme preparations exhibited temporally spaced clot inducing and subsequent
dissolving properties favoring hemostatic effect, procoagulant effect being dominant and the first
event. Significant reduction in fibrinogen absorbance at 540 nm with time, recalcification time and
human fibrinogenolytic product analysis on Tricine PAGE substantiated procoagulant effect. Disappearance
of Aα and Bβ fibrinopeptides by both stem and latex PPEs in the PAGE was observed. γ subunits
were completely hydrolysed by latex PPE, however, it showed comparative resistance to stem
PPE. Reduction in blood clot weight and fibrin subunit intensity supported thrombolytic property.

Conclusion:
The study provides evidence of the procoagulant and thrombolytic activity associated
with T. divaricata proteases.
Recent Patents on EDM of Nonconductive Materials
Authors: Xie Baocheng , Wang Yi 
Published: August 2020

Background:
The non-conductive materials are widely applied in electronics, optics, instrumentation,
aerospace, national defense and civil industry because of their strong wear resistance, high
hardness and good insulation performance. However, it is difficult for traditional machine methods to
process the non-conductive materials. Electrical Discharge Machining (EDM), as a nontraditional advanced
processing technology, is an alternative method for machining the non-conductive materials.
Therefore, the development trend of EDM of non-conductive materials has been paid more and more
attention.

Objective:
To meet the growing processing requirement of processing efficiency and processing quality of EDM of
nonconductive materials, the processing devices and processing methods of EDM of nonconductive materials such as
high-voltage spark machining, auxiliary electrode spark machining and electrolysis spark discharge machining are being
improved continuously.

Methods:
This paper retraces various current representative patents relative to high-voltage spark machining, auxiliary
electrode spark machining and electrolysis spark discharge machining of nonconductive materials.

Results:
Through investigating a large number of patents on EDM of nonconductive materials, the main current existing
problems such as low processing efficiency and poor processing quality are summarized and analyzed. Moreover, the
development tendency of EDM of nonconductive materials in the future is also discussed.

Conclusion:
The optimization of processing devices and processing methods of EDM of nonconductive materials is
conducive to improve processing efficiency and processing quality. More correlative patents will be invented in the future.