bluuebunny/crossref_metadata_2025_split huggingface dataset:
Socioeconomic inequalities in maternal health service utilisation: a case of antenatal care in Nigeria using a decomposition approach
Authors: Nwosu Chijioke O. , Ataguba John E. 
Published: November 2019

Abstract

Background
Antenatal care (ANC) services are critical for maternal health but Nigeria performs poorly in ANC utilisation compared to other countries in sub-Saharan Africa. This study aimed to assess socioeconomic inequalities in ANC utilisation and the determinants of these inequalities in Nigeria.

Methods
The 2013 Nigeria Demographic and Health Survey data with 18,559 women was used for analysis. The paper used concentration curves and indices for different measures of ANC utilisation (no ANC visit, 1–3 ANC visits, at least four ANC visits, and the number of ANC visits). A positive (or negative) concentration index means that the measure of ANC utilisation was concentrated on the richer (poorer) population compared to their poorer (richer) counterparts. The concentration indices were also decomposed using standard methodologies to examine the significant determinants of the socioeconomic inequalities in no ANC visit, at least four ANC visits, and the number of ANC visits.

Results
No ANC visit was disproportionately concentrated among the poor (concentration index (CI) = − 0.573), whereas at least four ANC visits (CI = 0.582) and a higher number of ANC visits (CI = 0.357) were disproportionately concentrated among the rich. While these results were consistent across all the geopolitical zones and rural and urban areas, the inequalities were more prevalent in the northern zones (which also have the highest incidence of poverty in the country) and the rural areas. The significant contributors to inequalities in ANC utilisation were the zone of residence, wealth, women’s education (especially secondary) and employment, urban-rural residence, ethnicity, spousal education, and problems with obtaining permission to seek health care and distance to the clinic.

Conclusions
Addressing wealth inequalities, enhancing literacy, employment and mitigating spatial impediments to health care use will reduce socioeconomic inequalities in ANC utilisation in Nigeria. These factors are the social determinants of health inequalities. Thus, a social determinants of health approach is needed to address socioeconomic inequalities in ANC coverage in Nigeria.
Effects of biofeedback-based sleep improvement program on urinary symptoms and sleep patterns of elderly Korean women with overactive bladder syndrome
Authors: Park Jooyeon , Park Choal Hee , Jun Sang-Eun , Lee Eun-Ju , Kang Seung Wan , Kim Nahyun 
Published: November 2019

AbstractBackgroundThe prevalence of overactive bladder syndrome (OAB) increases with age. Sleep disturbances in elderly individuals with OAB is a common problem. The purpose of this study was to examine the effects of a biofeedback-based sleep improvement (BBSI) program on urinary symptoms and sleep patterns in elderly Korean women with OAB.MethodsA non-equivalent control group pre−/post-test design was used. Elderly women with OAB were assigned to an intervention group (n = 20) or a control group (n = 18). The BBSI program was implemented in the intervention group for 12 weeks, while two educational sessions of general sleep hygiene and lifestyle modification were provided to the control group. Using SPSS 23.0, the data were analyzed by descriptive analysis using the chi-square test, Fisher’s exact test, Mann-Whitney test, and Wilcoxon test.ResultsAfter the 12-week BBSI program, significant improvements were found in the intervention group’s the square root of the mean squared differences of successive R-R intervals (p = 0.025), low frequency/high frequency ratio (p = 0.006), and epinephrine (p = 0.039). We also observed a significant difference in urinary symptoms, sleep efficiency, wake after sleep onset, number of awakenings, and number of awakenings within 3 h after sleep onset (p < 0.001,p = 0.004,p = 0.001,p = 0.001, andp = 0.048, respectively). However, no significant changes were found in these variables in the control group.ConclusionsThe BBSI program effectively improved urinary symptoms and sleep patterns of elderly Korean women with OAB. Further longitudinal research is required to investigate the sustainability and effects of the BBSI program.Trial registrationKCT0003882. Date of registration: 02/05/2019. Retrospectively registered.
Predictive factors related to the progression of periodontal disease in patients with early rheumatoid arthritis: a cohort study
Authors: Heredia-P Ana María , Lafaurie Gloria Inés , Bautista-Molano Wilson , Trujillo Tamy Goretty , Chalem-Choueka Philippe , Bello-Gualtero Juan M , Pacheco-Tena Cesar , Chila-Moreno Lorena , Romero-Sánchez Consuelo 
Published: November 2019

Abstract

Background
Rheumatoid arthritis (RA) and periodontal disease are inter-related conditions. However, factors predictive of periodontal disease progression in patients with early rheumatoid arthritis (eRA) are lacking. The aim of this study was to identify factors associated with the progression of clinical attachment loss (CAL) in interproximal dental sites of eRA patients.

Methods
Twenty-eight eRA patients were evaluated for the progression of CAL at 280 interproximal dental sites at 1 year of follow-up. Markers of RA activity (rheumatoid factor, erythrocyte sedimentation rate, and C-reactive protein), a marker of bone resorption (Dickkopf-related protein 1), Disease Activity Score 28 and Simple Disease Activity Index were included as potential systemic predictive factors. Plaque index, gingival index, pocket depth, clinical attachment level and Dickkopf-related protein 1 in crevicular fluid at baseline were included as potential local predictive factors. Data were analysed in a hierarchical structure using generalised linear mixed models for progression at each site (> 2 mm) during follow-up.

Results
C-reactive protein level was the most important predictive systemic factor for the progression of CAL. The mean CAL and a high degree of gingival inflammation in interproximal sites at baseline were important predictive local factors (p <  0.0001). Patients who received combined treatment with disease-modifying antirheumatic drugs and corticosteroids exhibited less CAL (p <  0.0001). The predictive value of the generalised linear mixed model for progression was 85%.

Conclusions
Systemic factors, including RA disease activity and baseline periodontal condition, were associated with periodontal progression. Pharmacological treatment may affect periodontal progression in patients with early RA.
Determinants of early marriage among married women in Injibara town, north West Ethiopia: community-based cross-sectional study
Authors: Bezie Minale , Addisu Dagne 
Published: November 2019

Abstract

Background
Early marriage is occurred when one or both of the spouses are below the age of 18 years at the time of their first marriage. It is one of the major traditional practices in developing counties particularly in Ethiopia; which has significant physical, intellectual, psychological and emotional effects and reduces educational opportunities and the chance for personal growth for both boys and girls. Even though this traditional practice was the common cultural events in the study area, there is no prior study on the magnitude and its determinant factors. Hence, the study was aimed to determine the prevalence and determinant factors of early marriage among married women in Injibara town, North West Ethiopia.

Methods
A Community-based cross-sectional study was conducted from September to December 2018. A total of 373 women were included in the study. A multistage sampling procedure was applied to select the study participants. Data analysis was done by using SPSS versions 23. Both descriptive & analytical statistics were computed. Statistical significance was considered at P < 0.05 and the strength of association were assessed by using adjusted odds ratio with 95% confidence interval.

Result
The prevalence of early marriage was 167(44.8%). The minimum and maximum ages at first marriage were 9 and 23 years respectively. Non-formal educational level of the father [Adjusted Odd Ratio (AOR) =2.32; 95%CI = 1.33–4.05], family’s average monthly income <1000 Ethiopian birr [AOR = 2.32, 95%CI = 1.27–4.24], family size ≥7 [AOR = 3.59, 95%CI = 1.94–6.63] and non-formal education level of the respondents [AOR = 5.16; 95%CI = 2.87–9.28] were found to be associated with early marriage.

Conclusion
The prevalence of early marriage was high in Injibara town, Ethiopia. Factors that tend to facilitate early marriage in this town include family income, family size, educational level of the father and that of the respondent. Improving on the strategies that promote formal education will reduce the level of early marriage in Injibara town, Ethiopia.
Correlation of online assessment parameters with summative exam performance in undergraduate medical education of pharmacology: a prospective cohort study
Authors: Kühbeck Felizian , Berberat Pascal O. , Engelhardt Stefan , Sarikas Antonio 
Published: November 2019

Abstract

Background
Learning analytics aims to improve learning outcomes through the systematic measurement and analysis of learning-related data. However, which parameters have the highest predictive power for academic performance remains to be elucidated. The aim of this study was to investigate the correlation of different online assessment parameters with summative exam performance in undergraduate medical education of pharmacology.

Methods
A prospective study was conducted with a cohort of undergraduate medical students enrolled in a pharmacology course at Technical University of Munich, Germany. After a four-week teaching and learning period, students were given access to an online assessment platform consisting of 440 multiple choice (MC) questions. After 12 days, a final written summative exam was performed. Bivariate correlation and multiple regression analyses were performed for different online assessment parameters as predictors and summative exam performance as dependent variable. Self-perceived pharmacology competence was measured by questionnaires pre- and postintervention.

Results
A total of 224 out of 393 (57%) students participated in the study and were included in the analysis. There was no significant correlation for the parameters “number of logins” (r = 0.01, p = 0.893), “number of MC-questions answered” (r = 0.02, p = 0.813) and “time spent on the assessment platform” (r = − 0.05, p = 0.459) with exam performance. The variable “time per question” was statistically significant (p = 0.006), but correlated negatively (r = − 0.18) with academic performance of study participants. Only “total score” (r = 0.71, p < 0.001) and the “score of first attempt” (r = 0.72, p < 0.001) were significantly correlated with final grades. In a multiple regression analysis, “score first attempt” accounted for 52% of the variation of “score final exam”, and “time per question” and “total score” for additional 5 and 1.4%, respectively. No gender-specific differences were observed. Finally, online assessments resulted in improved self-perceived pharmacology competence of students.

Conclusion
In this prospective cohort study, we systematically assessed the correlation of different online assessments parameters with exam performance and their gender-neutrality. Our findings may help to improve predictive models of academic performance in undergraduate medical education of pharmacology.
To examine the associations between medical students’ conceptions of learning, strategies to learning, and learning outcome in a medical humanities course
Authors: Chiu Yu-Chun , Liang Jyh-Chong , Hsu Hong-Yuan , Chu Tzong-Shinn , Lin Kuan-Han , Chen Yen-Yuan , Tsai Chin-Chung 
Published: November 2019

AbstractBackgroundBy learning medical humanities, medical students are expected to shift from handling the diseases only to seeing a whole sick person. Therefore, understanding medical students’ learning process and outcomes of medical humanities becomes an essential issue of medical education. Few studies have been conducted to explore factors surrounding medical students’ learning process and outcomes of medical humanities. The objectives were: (1) to investigate the relationships between medical students’ conceptions of learning and strategies to learning; and (2) to examine the relationships between students’ strategies to learning and learning outcomes for medical humanities.MethodsWe used the modified Approaches to Learning Medicine (mALM) questionnaire and Conceptions of Learning Medicine (COLM) questionnaire to measure the medical students’ strategies to learning and conceptions of learning respectively. The learning outcome of medical humanities was measured using students’ weighted grade in a medical humanities course. The confirmatory factor analysis (CFA) was used to validate the COLM and mALM questionnaires, in which construct validity and reliability were assessed. Pearson’s correlation was used to examine the relationships among the factors of COLM, mALM, and the weighted grade. Path analysis using structural equation modeling technique (SEM) was employed to estimate the structural relationships among the COLM, mALM, and the weighted grade.ResultsTwo hundred and seventy-five first-year medical students consented to participate in this study. The participants adopting surface strategies to learning were more likely to have unsatisfactory learning outcome (β = − 0.14,p = .04). The basic-level conception of “Preparing for Testing” was negatively (β = − 0.19,p < .01) associated with deep strategies of learning, and positively (β = 0.48,p < .01) associated with surface strategies of learning (β = 0.50,p < .01). The basic-level conception of “Skills Acquisition” was positively associated with deep strategies of learning (β = 0.23,p < .01).ConclusionMedical educators should wisely employ teaching strategies to increase students’ engagement with deep and self-directed learning strategies, and to avoid using surface learning strategies in the medical humanities course in order to achieve better learning outcomes.
Seroprevalence and associated risk factors of leptospirosis in slaughter pigs; a neglected public health risk, western Kenya
Authors: Ngugi Jeremiah N. , Fèvre Eric M. , Mgode Georgies F. , Obonyo Mark , Mhamphi Ginethon G. , Otieno Christina A. , Cook Elizabeth Anne Jessie 
Published: November 2019

AbstractBackgroundLeptospirosis is a neglected zoonosis of public health importance transmitted through contact with contaminated soil, water or urine of infected animals. In pigs the disease is characterized by abortion, still births and weak piglets. A cross-sectional study was conducted in May to July 2018 to estimate the sero-prevalence of leptospirosis and factors associated with seropositivity in slaughter pigs. A questionnaire was used to collect information on animal demographics. Serum was tested for anti-leptospiral antibodies using microscopic agglutination test (MAT) with a panel of 8 serovars. Sera were considered positive for sero-reactivity at a MAT titre ≥1:40 against at least one serovar. Chi-square tests were used to measure the strength of association between the MAT test result and exploratory variables.ResultsA total of 252 pig serum samples from seven slaughterhouses were tested forLeptospiraantibodies by MAT. Of the 252 pigs sampled, 88.8% (244/252) were indigenous breeds; 55.6% (140/252) were female and 88.7% (220/252) were reared in extensive production systems. Eighty-three (32.9%; 83/252) sera samples tested positive on MAT against at least one serovar. Of the 8 serovars, the highest prevalence was recorded for serovar Lora 21.4% followed by Kenya 5.2%, Sokoine 3.6% and Grippotyphosa at 3.2%. Risk factors for leptospirosis seropositivity in pigs were: originating from farms with other types of livestock (OR 2.3; 95% CI 1.0–4.5) and mature pigs (OR 1.9; 95% CI 1.1–3.3).ConclusionThis study demonstrates that there is a high prevalence of leptospirosis positive pigs at slaughter in a small-holder livestock keeping region of the Lake Victoria basin. The potential for cross species transmission of pathogenic serovars is highlighted as well as the potential for occupational exposure to slaughterhouse personnel. Improvements in husbandry practices (confinement and rodent control) and public health education among slaughterhouse workers and other high-risk groups is recommended.
A functional polymorphism in the promoter of miR-17-92 cluster is associated with decreased risk of ischemic stroke
Authors: Huang Huatuo , Wei Guijiang , Wang Chunfang , Lu Yulan , Liu Chunhong , Wang Rong , Shi Xiang , Yang Jun , Wei Yesheng 
Published: November 2019

Abstract

Background
The microRNA-17-92 (miR-17-92) cluster is one of the most extensively studied miRNA clusters. Abnormal expression of the cluster has been found to play important role in different kinds of human diseases, including ischemic stroke (IS). The aim of our study was to investigate the association between three polymorphisms (rs1491034, rs9301654 and rs982873) in the promoter of the miR-17-92 cluster and risk of IS.

Methods
Three hundred and ninety-eight patients with IS and 397 control subjects were included. The genotypes of the three polymorphisms were determined by Snapshot SNP genotyping assay. Relative expression of the cluster in peripheral blood mononuclear cells (PBMCs) of cases and controls were examined by quantitative real-time PCR.

Results
Significant association between rs9301654 polymorphism and risk of IS were observed basing on genotype, model and allele analyses (GA vs. AA: adjusted OR = 0.63, 95% CI: 0.41~0.97, P = 0.037; GG vs. AA: adjusted OR = 0.23, 95% CI: 0.07~0.78, P = 0.018; GA + GG vs. AA: adjusted OR = 0.57, 95% CI: 0.38~0.87, P = 0.009; GA + AA vs. GG: adjusted OR = 0.27, 95% CI: 0.08~0.89, P = 0.032; G vs. A: adjusted OR = 0.58, 95% CI: 0.40~0.83). Haplotype analysis showed that TGC and TGT haplotypes were associated with decreased risk of IS (OR = 0.59, 95% CI: 0.40~0.87, P = 0.007 for TGC haplotype; OR = 0.21, 95% CI: 0.06~0.75, P = 0.009 for TGT haplotype). Importantly, we found the expression of miR-17-5p was significant higher while miR-19a-3p was significant lower in patient with IS compared with the control group (P < 0.01), and patients with rs9301654GG or GA genotype displayed lower level of miR-19a-3p compared with the AA genotype (P < 0.01).

Conclusions
Our findings indicated that rs9301654 polymorphism in the promoter of miR-17-92 cluster may be associated with susceptibility of IS in the Chinese population. However, we found that rs9301654 polymorphism and its respective gene expression did not demonstrate consistent association with IS in the Chinese population. Further studies such as gene-gene interaction are warranted to reveal the role of miR-19a and its regulatory genes in the etiology of IS.
Engineering and characterising a novel, highly potent bispecific antibody iMab-CAP256 that targets HIV-1
Authors: Moshoette Tumelo , Ali Stuart Alvaro , Papathanasopoulos Maria Antonia , Killick Mark Andrew 
Published: November 2019

AbstractThe existing repertoire of HIV-1 patient derived broadly neutralising antibodies (bNAbs) that target the HIV-1 envelope glycoprotein (Env) present numerous and exciting opportunities for immune-based therapeutic and preventative strategies against HIV-1. Combination antibody therapy is required to ensure greater neutralization coverage and limit Env mediated escape mutations following treatment pressure. Engineered bispecific bNAbs (bibNAbs) assimilate the advantages of combination therapy into a single antibody molecule with several configurations reporting potency enhancement as a result of the increased avidity and simultaneous engagement of targeted epitopes. We report the engineering of a novel bibNAb (iMab-CAP256) comprising the highly potent, CAP256.VRC26.25 bNAb with anticipated extension in neutralization coverage through pairing with the host directed, anti-CD4 antibody, ibalizumab (iMab). Recombinant expression of parental monoclonal antibodies and the iMab-CAP256 bibNAb was performed in HEK293T (Human embryonic kidney 293 T antigen) cells, purified to homogeneity by Protein-A affinity chromatography followed by size exclusion chromatography. Antibody assembly and binding functionality of Fab moieties was confirmed by SDS-PAGE (sodium dodecyl sulphate polyacrylamide gel electrophoresis) and ELISA, respectively. Breadth and potency were evaluated against a geographical diverse HIV-1 pseudovirus panel (n = 20). Overall, iMab-CAP256 demonstrated an expanded neutralizing coverage, neutralizing single, parental antibody resistant pseudovirus strains and an enhanced neutralization potency against all dual sensitive strains (average fold increase over the more potent parental antibody of 11.4 (range 2 to 31.8). Potency enhancement was not observed for the parental antibody combination treatment (iMab + CAP256) suggesting the presence of a synergistic relationship between the CAP256 and iMab paratope combination in this bibNAb configuration. In addition, iMab-CAP256 bibNAbs exhibited comparable efficacy to other bibNAbs PG9-iMab and 10E08-iMab previously reported in the literature. The enhanced neutralization coverage and potency of iMAb-CAP256 over the parental bNAbs should facilitate superior clinical performance as a therapeutic or preventative strategy against HIV-1.
Beyond mapping: a case for geospatial analytics in humanitarian health
Authors: Greenough P. Gregg , Nelson Erica L. 
Published: November 2019

Abstract
The humanitarian sector is increasingly adopting geospatial data to support operations. However, the utilization of these data in the humanitarian health arena is predominantly in thematic map format, thereby limiting the full insight and utility of geospatial information.
Geospatial analytics, in contrast, including pattern analysis, interpolation, and predictive modeling, have tremendous potential within the field of humanitarian health. This paper explores a variety of historical and contemporary geospatial applications in the public health and humanitarian fields and argues for greater integration of geospatial analysis into humanitarian health research and programming. From remote sensing to create sampling frames, to spatial interpolation for environmental exposure analysis, and multi-objective optimization algorithms for humanitarian logistics, spatial analysis has transformed epistemological paradigms, research methods and programming landscapes across diverse disciplines.
The field of humanitarian health, which is inextricably bounded by geography and resource limitations, should leverage the unique capacities of spatial methods and strategically integrate geospatial analytics into research and programming not only to fortify the academic legitimacy and professionalization of the field but also to improve operational efficiency and mitigation strategies.