bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proton pump inhibitors enhance chemosensitivity, promote apoptosis, and suppress migration of breast cancer cells
Authors: Ihraiz Worood G. , Ahram Mamoun , Bardaweel Sanaa K. 
Published: January 2020

Abstract
Breast cancer is the most common cancer and is the leading cause of cancer deaths among women worldwide. Despite the availability of numerous therapeutics for breast cancer management, cytotoxicity and emergence of drug resistance are major challenges that limit their benefits. The acidic microenvironment surrounding tumor cells is a common feature inducing cancer cell invasiveness and chemoresistance. Proton pump inhibitors (PPIs) are one of the most commonly prescribed drugs for the treatment of acid-related conditions. PPIs have been reported to exhibit antitumorigenic effects in many cancer types. In this study, the anti-proliferative and anti-migratory effects of PPIs in three breast cancer cell lines; MCF-7, T47D, and MDA-MB-231 cells, have been investigated. In addition, the combined effects of PPIs with anticancer drugs, as well as the mechanism of PPI-mediated anti-proliferative activity were evaluated. The anti-proliferative and combined effects of PPIs were evaluated by MTT assay. Cell migration was assessed using the wound-healing assay. The mechanism of cell death was assessed using annexin V-FITC/propidium iodide staining flow cytometry method. Our results indicated that PPIs treatment significantly inhibited the growth of breast cancer cells in a dose-dependent manner. The antiproliferative activity of PPIs was significantly induced by apoptosis in all tested cell lines. The combined treatment of PPIs with doxorubicin resulted in a synergistic effect in all cell lines, whereas the combined treatment with raloxifene exhibited synergistic effect in T47D cells only and additive effects in MDA-MB-231 and MCF-7 cells. In addition, PPIs treatment significantly reduced cell migration in MDA-MB-231 cells. In conclusion, the addition of PPIs to the treatment regimen of breast cancer appears to be a promising strategy to potentiate the efficacy of chemotherapy and may suppress cancer metastasis.
Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors
Authors: Zaher Nashwa Hafez , Mostafa Mohammed Ismail , Altaher Abdullah Yousef 
Published: January 2020

Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) had emerged and spread because of the worldwide travel and inefficient healthcare provided for the infected patients in several countries. Herein we investigated the anti-MERS-CoV activity of newly synthesized sixteen halogenated triazole compounds through the inhibition of helicase activity using the FRET assay. All new compounds underwent justification for their target structures via microanalytical and spectral data. SAR studies were performed. Biological results revealed that the most potent compounds were 4-(cyclopent-1-en-3-ylamino)-5-(2-(4-iodophenyl)hydrazinyl)-4H-1,2,4-triazole-3-thiol (16) and 4-(cyclopent-1-en-3-ylamino)-5-[2-(4-chlorophenyl)hydrazinyl]-4H-1,2,4-triazole-3-thiol (12). In silico molecular docking of the most potent compounds was performed to the active binding site of MERS-CoV helicase nsp13. Molecular docking results are in agreement with experimental findings.
Atmospheric Plasma Spraying of Al2O3 + 13% TiO2 Coatings Using External and Internal Injection System
Authors: Łatka L. , Michalak M. , Jonda E. 
Published: January 2020

Abstract
The ceramic coatings based on mixture of Al2O3 and TiO2 have better properties in comparison to the pure alumina ones. Among many techniques, plasma spraying is very useful method of ceramic coatings manufacturing. In this paper, the results of microscopic, mechanical and tribological properties investigations of Al2O3 + 13 wt% TiO2 coatings manufactured by atmospheric plasma spraying are presented. The cylinder substrates made from stainless steel (X5CrNi18-10) had a diameter equal to 25 mm and thickness equal to 2 mm. The plasma spray experimental parameters included three variables: (i) type of injection system (external or internal), (ii) size of corundum particles for sandblasting and (iii) torch linear speed. The results confirm, that type of injection system is a dominant parameter. Internal injection results in better degree of particles melting, what influences on wear resistance performance, as well as higher values of bond strength.
Effect of Slide Burnishing on the Surface Layer and Fatigue Life of Titanium Alloy Parts
Authors: Zaleski K. , Skoczylas A. 
Published: January 2020

Abstract
The paper presents the results of a study investigating the effect of slide burnishing on the surface roughness, surface layer microhardness and fatigue life of Ti6Al2Mo2Cr titanium alloy parts. The burnishing process was performed with the use of a diamond tip tool. Different machining fluids were used as machining media. Prior to burnishing, the samples were subjected to turning. The burnishing process led to reduced surface roughness (average roughness Ra decreased by 3.5 times and roughness Rz decreased by 2.5 times) as well as increased surface layer microhardness (microhardness maximum increase by 12%) and fatigue life of the tested parts. A relationship between the machining medium and the burnishing effects was also observed. The addition of a surface-active polymethyl methacrylate solution to the machining medium led to an increase in the surface layer microhardness and fatigue life of the workpiece.
Effect of Storage Conditions of Rutile Flux Cored Welding Wires on Properties of Welds
Authors: Świerczyńska A. 
Published: January 2020

Abstract
The influence of storage locations of two grades of rutile flux cored welding wires on their surface condition and the strength of the welds made with them were studied. Wires were stored in real urban conditions (Gdańsk and Katowice) for 1 month, simultaneously recording changes in conditions: temperature and relative humidity of the environment. Visual tests of wires in the delivered and stored condition as well as visual and tensile strength tests of welds made with them were carried out. It was found that the surface of the wires underwent more intense degradation (atmospheric corrosion) during storage in Katowice than in Gdańsk. Significant difference in tensile strength was observed only for padding welds made using Gdańsk stored wires. The lowest recorded tensile strength value was not lower than the standard requirements for the wires.
Application of the 3D Digital Image Correlation to the Analysis of Deformation of Joints Welded With the FSW Method After Shot Peening
Authors: Kubit A. , Bucior M. , Kluz R. , Święch Ł. , Ochał K. 
Published: January 2020

Abstract
The three dimensional Digital Image Correlation (3D DIC) method is used for measurements of deformations and displacement in plane elements exposed to loading. The paper presents the experimental tests of an application of the ARAMIS system to the analysis of deformation of joints welded with the FSW method after shot peening treatment. The butt joints were made of 2024-T3 aluminum alloy sheets with the thickness of 1 mm, which next were peened with glass beads about granulation in range 500 ÷ 900 µm. Tests of residual stresses by X-ray diffraction were also carried out. The aim of the study was to analyze the impact of shot peening on the value of stresses and the location of deformations in butt joints.
Advances in Carbon Fiber Reinforced Polyamide-Based Composite Materials
Authors: Kausar A. 
Published: January 2020

Abstract
Carbon fiber has been used to reinforce both aliphatic and aromatic polyamides. Aliphatic polyamide is known as nylon and aromatic polyamide is often referred to as aramid. Among aliphatic polyamides, polyamide 6, polyamide 6,6, polyamide 11, polyamide 12, and polyamide 1010 have been used as matrices for carbon fiber. Factors affecting the properties of polyamide/carbon fiber composites are: fiber amount, fiber length, fiber orientation, matrix viscosity, matrix-fiber interactions, matrix-fiber adhesion, and conditions encountered during manufacturing processes. This article presents a state-of-the-art review on polyamide/carbon fiber composites. Polyamide/carbon fiber composites are lightweight and exhibit high strength, modulus, fatigue resistance, wear resistance, corrosion resistance, gear, electrical conductivity, thermal conductivity, chemical inertness, and thermal stability. Incorporation of oxidized or modified carbon fiber and nanoparticle modified carbon fiber into polyamide matrices have been found to further enhance their physical properties. Applications of polyamide/carbon fiber composites in aerospace, automobile, construction, and other industries have been stated in this review. To fully exploit potential of polyamide/carbon fiber composites, concentrated future attempts are needed in this field.
In Vitro Pro-Glycative Effects of Resveratrol and Caffeic Acid
Authors: Kurin E. , Mučaji P. , Nagy M. 
Published: January 2020

Abstract
Resveratrol and caffeic acid belong to plant polyphenols and are known for their antioxidant effects. The aim of our research was to study their impact on Maillard reaction. This one occurs when the reducing saccharides react with amino groups of biomolecules including proteins, alter their protein conformation and transform to the variety of advanced glycation end products (AGEs). AGEs exhibit browning and generate fluorescence. There exist expectations that this oxidative protein glycosylation could be prevented by antioxidants. In this study, we incubated bovine serum albumin (BSA) with glucose for 7 days at 37°C and measured characteristic fluorescence and UV absorbance of the formed AGEs. Surprisingly, resveratrol and caffeic acid enhanced transformation of BSA to glycation products, which was confirmed either when cupric Cu(II) or ferric Fe(III) ions in nanomolar concentration were added to the system as pro-oxidant agent.
On J-colorability of certain derived graph classes
Authors: Fornasiero Federico , Naduvath Sudev 
Published: January 2020

AbstractA vertex v of a given graph G is said to be in a rainbow neighbourhood of G, with respect to a proper coloring C of G, if the closed neighbourhood N[v] of the vertex v consists of at least one vertex from every color class of G with respect to C. A maximal proper coloring of a graph G is a J-coloring of G such that every vertex of G belongs to a rainbow neighbourhood of G. In this paper, we study certain parameters related to J-coloring of certain Mycielski-type graphs.
Development of Mask Design Knowledge Base Based on Sensory Evaluation and Fuzzy Logic
Authors: Hong Yan , Xue Zhebin , Liu Chunyu , Dai Xiaoqun 
Published: January 2020

Abstract
This article focuses on the development of the mask design knowledge base, which is expected to be applied in a personalized mask design system. To realize the proposed knowledge base, a perceptual descriptive space of the mask is first developed for the description of both functional and aesthetic perceptions of a mask. The mask ontology is also developed to form the mask element matrix. Mask design knowledge is expressed as the relationship between the perceptual descriptive space and the mask ontology, which is extracted by a group of experienced designers through a sensory evaluation procedure. This relationship is then simulated by fuzzy logic tools. The proposed knowledge base has been validated that it is reliable. The personalized mask design system can be further developed with the propose mask design knowledge base.
Electronic and Thermoelectric Properties in Li-Based Half-Heusler Compounds: A First Principle Study
Authors: Benazouzi Y. , Rozale H. , Boukli Hacene M. A. , Khethir M. , Chahed A. , Lucache D. 
Published: January 2020

Abstract
In this paper, we performed a first principle study for new half-Heusler LiSrX(X= N, P, and As) working with WIEN2k code in the frame work of the density functional theory, and the Boltzmann theory. We estimated the exchange-correlation potential by the generalized gradient approximation (GGA). Energetically, the three compounds show a high stability in structure type2, we notice that the lattice constant increased while bulk modulus decreased in replacing the ions of size increasing. Based on our calculations, LiSrN, LiSrP, and LiSrAs compounds are mechanically stable, and show semiconductor nature with indirect band gaps of 1.21, 1.75 for LiSrN and LiSrAs, and direct band gap of 1.94 eV for LiSrP. The thermoelectric properties are calculated for LiSrX (X=N, P, and As) and they found a high power factor for the p-type doping concentration.
Assessing the role of soil microbial communities of natural forest ecosystem
Authors: Matei Gabi-Mirela , Matei Sorin , Mocanu Victoria 
Published: January 2020

AbstractIn forests, edaphic microbial communities are involved in litter decomposition and soil forming processes, with major contribution to humification, especially bacteria and fungi being responsible for the main ecosystem services fulfilled by the soil. Research has been carried out aiming to characterize the structure and diversity of microbial communities in the Rendzic Leptosols (WRB) under natural deciduous forest from Visterna, Babadag Plateau and to assess their contribution to ecosystem services provided by soil. The paper presents the results of quantitative estimations and taxonomic composition of soil and litter communities of heterotrophic bacteria and fungi, identification of cellulolytic species, as well as the microbial biomass and global physiological activities expressed as soil respiration potential. More than a half of bacterial species were common in litter and soil (SI=57.14%) and were represented by dominant species of fluorescent or non-fluorescent pseudomonads andBacillus subtilisbut no similarity was found between the two fungal communities. Fungal populations included cosmopolitan species, such as antagonists and strong cellulolytic representatives of generaPenicillium,Trichoderma, Mortierella, Chaetomium, Epicoccum, Aspergillus. Microbial density and microbial biomass presented the highest values in the litter (684 mg C x kg-1d.s.) and in surface horizon Am1 of soil profile than in the bottom layers. The highest diversity was found in Am1 horizon (0-5 cm) H’=1.983 bits and ε=0.869 for cellulolytic community. Soil respiration reflected the intense physiological activity of microbiome, with high values associated to numerous effectives of bacteria and fungi especially in surface horizon. Microorganisms identified contribute to formation of soil by recycling of nutrients, cellulose decomposition, the synthesis of stable organic matter (humic acids), aggregation of soil particles, biological control of pathogens by antagonistic activity. They improve plant uptake of water and nutrients by forming symbioses (ectomycorrhizae), thus modelling the structure of vegetation.
Evaluation of Achillea millefolium essential oil compounds and biological effects on cervix cancer HeLa cell line
Authors: Acar Mustafa Burak , İbiş Ebru Karadaş , Şimşek Ahmet , Vural Cem , Tez Coşkun , Özcan Servet 
Published: January 2020

Abstract
Yarrow essential oil is used in complementary and alternative therapy for several diseases. Biological effects of essential oils span various cells and microorganisms. The aim of this study was to investigate the effects of different concentrations of the essential oil obtained from the yarrow plant (Achillea millefolium) on HeLa (CCL-2) cells. The components of the essential oil were studied by means of GC-MS analysis. Out of 10 determined compounds in the essential oil; 1,8-Cineole, Camphor, Beta-eudesmol and Camphene were found to be higher than others; and their biological effects were depicted with Ingeniuty Pathway Analysis (IPA) analysis. Moreover, cell cycle and proliferation tests were conducted on HeLa cells where yarrow plant’s essential oil was used. When extracted yarrow oil applied on HeLA Cells, apoptotic effects had been determined, furthermore proliferation of these cells decreased. In addition, activation of cell cycle control points was observed . Essential oil components could arrest the development of HeLa cells due to induction of cellular damage control mechanisms. In conclusion, we propose that the essential oil had a more repressive effect on HeLa cells, decreases their proliferation and prevented the increase in the number of cells.
The role of C-terminal amidation in the mechanism of action of the antimicrobial peptide aurein 1.2
Authors: Shahmiri Mahdi , Mechler Adam 
Published: January 2020

Abstract
C-terminal amidation is a common feature of wild type membrane disrupting antimicrobial peptides (AMPs). Empirical evidence suggests that this modification increases antimicrobial efficacy. However, the actual role of C-terminal amidation in the molecular mechanism of action of AMPs is not fully understood. Amidation alters two key properties simultaneously: the net charge and helicity of the peptide, both of which are implicated in the mechanism of action. However, the differences between the physicochemical properties of the carboxyl and amide moieties have been disregarded in former studies. In this study we assessed whether the difference in activity is only caused by changes in the helicity and overall charge of a peptide, i.e. whether the chemistry of the terminus is otherwise irrelevant. To do so, the membrane disrupting activity of a modified aurein 1.2 peptide was studied in which a secondary amide was formed with a terminal methyl group, instead of the primary amide as in the wild type peptide. Results of quartz crystal microbalance, dye leakage and circular dichroism experiments show that the activity of the modified peptide is substantially reduced compared to the wild type peptide, in particular that the modified peptide exhibited a much-reduced ability to bind to the membrane. Thus, the primary amide at the C-terminus is required to bind to the membrane, and a secondary amide cannot serve the same purpose. We hypothesize that this difference is related to the hydration state of the terminus. The lack of membrane binding ability of the modified peptide identifies the primary amide moiety at the C terminus as a specific membrane binding motif.
Effects of zinc and molybdenum on European Bluestar (Amsonia orientalis): An in vitro study
Authors: Acemi Arda , Duman Yonca Avcı , Karakuş Yonca Yüzügüllü , Özen Fazıl 
Published: January 2020

Abstract
This study aimed to investigate the effects of possible zinc (Zn) and molybdenum (Mo) contaminations on the critically endangered European Bluestar (Amsonia orientalis). The effects of Zn and Mo were tested in a dose-dependent manner on in vitro cultures. Zn at 0.1 mM in the medium inhibited root development whereas Mo showed the same effect only at ≥2.5 mM concentration. Gradual inhibition of shoot development was observed after treatment with both metals. Protein contents were also negatively affected by increasing metal concentrations, while proline levels increased gradually. Successive increases in metal concentrations resulted in higher hydrogen peroxide (H2O2) and malondialdehyde (MDA) concentrations. The activity of the antioxidant enzymes, peroxidase (POD) and catalase (CAT), were found to be enhanced in response to increasing metal concentrations. Superoxide dismutase (SOD) activity decreased after Zn treatment but increased after Mo treatment. A marked increase in POD and CAT in response to metal stress suggests that these enzymes might have a significant cooperative role in regulating H2O2 production, although CAT, in response to drought and salt stress, has been reported to only play a supplementary role in A. orientalis. These results indicated that A. orientalis is susceptible to long-term Zn stress but can tolerate up to 2.5 mM Mo in the long-term. Deficiency of Mo is more common than high toxic concentrations in the environment. Therefore Zn contamination should be considered as one of the major threats for A. orientalis in its native habitat.
Compared salt tolerance of five local wheat (Triticum aestivum L.) cultivars of Albania based on morphology, pigment synthesis and glutathione content
Authors: Bacu Ariola , Ibro Vjollca , Nushi Magdalena 
Published: January 2020

Abstract
Stressful saline concentrations in soils affect photosynthesis by damaging pigments, photosystems, components of electron transport system, and enzymes involved in the process. Plants respond through very complex stress adaptation mechanisms including proteome modulation, alterations in pigment content, cell osmotic adjustment and control of ion and water homeostasis mechanisms, which stabilize cytosolic glutathione redox potential, etc. The level of plant sensitivity depends on salt toxicity levels, growth stage, physiological and genetic factors. With aim the investigation of the salinity tolerant cultivars, and for the elucidation of mechanisms underlying this complex biological process, here we analyze the impact of four NaCl concentrations (0-50-100-200mM) in growth parameters (root, shoot and leaves length), pigment content (chla, chlb, carotenoids), and GSH content, during seedling of five bread wheat (Triticum aestivum L.) cultivars in modified Hoagland solutions. Based on biometric parameters, pigment synthesis and GSH content cultivar Nogal is salt-sensitive (growth and pigments reduced); cultivar Viktoria is medium-tolerant (growth partially impaired, pigments constant), cultivar Toborzo and cultivar Suba are medium-tolerant (growth partially impaired, pigments increased), cultivar Dajti salt-tolerant (growth partially impaired/ leaves developed, pigments increased). Quantity of GSH in response to different levels of salinity is cultivar specific, and time of exposure to salinity is in negative correlation to GSH content for all investigated cultivars.
Impact of Green Practices on Buying Habits in Pakistan’s Food Sector
Authors: Jafar Rana Adeel , Shabbir Aiza , Kousar Farzana 
Published: January 2020

Abstract
The review intends to research the green advertising practices and its consequences for the client’s image inclination in sustenance segment of Pakistan.
Design/methodology/approach-Data is gathered by using 5 point scale through strongly disagree to strongly agree. it include 15 items about respondents graphics It contains questions about demographics, green brand image, environment concern, green brand awareness, and green brand preferences. The data was collected from different Universities (G.C University, University of Punjab, University of Engineering and Technology) in Lahore Pakistan. In this study cluster sampling is used.
Findings- This study shows significant results with respect to green brand preference and its critical characteristics of student brand awareness. This study concluded that the importance of green brand elements (green brand image, environment concern, on green brand awareness, H1 H2 H4.H4 are accepted.
Originality - Past writing recommends an Essential association among green showcasing and purchaser mark inclinations yet in Pakistan there is an absence of such examination. So to fill this hole this exploration is led by utilizing quantitative procedures. We circulate poll 60 shoppers and capability of sustenance segment on the premise of accommodation examining to get the outcomes with regards to Pakistan.