bluuebunny/crossref_metadata_2025_split huggingface dataset:
MS-CleanR: A feature-filtering approach to improve annotation rate in untargeted LC-MS based metabolomics
Authors: Fraisier-Vannier Ophélie , Chervin Justine , Cabanac Guillaume , Puech-Pages Virginie , Fournier Sylvie , Durand Virginie , Amiel Aurélien , André Olivier , Benamar Omar Abdelaziz , Dumas Bernard , Tsugawa Hiroshi , Marti Guillaume 
Published: April 2020

AbstractUntargeted metabolomics using liquid chromatography-mass spectrometry (LC-MS) is currently the gold-standard technique to determine the full chemical diversity in biological samples. This approach still has many limitations, however; notably, the difficulty of estimating accurately the number of unique metabolites being profiled among the thousands of MS ion signals arising from chromatograms. Here, we describe a new workflow, MS-CleanR, based on the MS-DIAL/MS-FINDER suite, which tackles feature degeneracy and improves annotation rates. We show that implementation of MS-CleanR reduces the number of signals by nearly 80% while retaining 95% of unique metabolite features. Moreover, the annotation results from MS-FINDER can be ranked with respect to database chosen by the user, which improves identification accuracy. Application of MS-CleanR to the analysis ofArabidopsis thalianagrown in three different conditions improved class separation resulting from multivariate data analysis and lead to annotation of 75% of the final features. The full workflow was applied to metabolomic profiles from three strains of the leguminous plantMedicago truncatulathat have different susceptibilities to the oomycete pathogenAphanomyces euteiches; a group of glycosylated triterpenoids overrepresented in resistant lines were identified as candidate compounds conferring pathogen resistance. MS-CleanR is implemented through a Shiny interface for intuitive use by end-users (available at:https://github.com/eMetaboHUB/MS-CleanR).
Pattern-recognition receptors are required for NLR-mediated plant immunity
Authors: Yuan Minhang , Jiang Zeyu , Bi Guozhi , Nomura Kinya , Liu Menghui , He Sheng Yang , Zhou Jian-Min , Xin Xiu-Fang 
Published: April 2020

AbstractThe plant immune system is fundamental to plant survival in natural ecosystems and productivity in crop fields. Substantial evidence supports the prevailing notion that plants possess a two-tiered innate immune system, called pattern-triggered immunity (PTI) and effector-triggered immunity (ETI). PTI is triggered by microbial patterns via cell surface-localized pattern-recognition receptors (PRRs), whereas ETI is activated by pathogen effector proteins via mostly intracellularly-localized receptors called nucleotide-binding, leucine-rich repeat proteins (NLRs)1-4. PTI and ETI are initiated by dist 30 inct activation mechanisms and are considered to act independently and have evolved sequentially5,6. Here we show that, contrary to the perception of PTI and ETI being separate immune signaling pathways, Arabidopsis PRR/co-receptor mutants,fls2/efr/cerk1andbak1/bkk1/cerk1triple mutants, are greatly impaired in ETI responses when challenged with incompatiblePseudomonas syrinagebacteria. We further show that the NADPH oxidase (RBOHD)-mediated production of reactive oxygen species (ROS) is a critical early signaling event connecting PRR and NLR cascades and that PRR-mediated phosphorylation of RBOHD is necessary for full activation of RBOHD during ETI. Furthermore, NLR signaling rapidly augments the transcript and protein levels of key PTI components at an early stage and in a salicylic acid-independent manner. Our study supports an alternative model in which PTI is in fact an indispensable component of ETI during bacterial infection, implying that ETI halts pathogen infection, in part, by directly co-opting the anti-pathogen mechanisms proposed for PTI. This alternative model conceptually unites two major immune signaling pathways in the plant kingdom and mechanistically explains the long-observed similarities in downstream defense outputs between PTI and ETI.
The impact of sensory activity schedule (SAS) intervention on classroom task performance in students with autism – a pilot randomised controlled trial
Authors: Mills Caroline Jennifer , Chapparo Christine , Hinitt Joanne 
Published: April 2020

Purpose
Sensory processing difficulties can negatively affect children with autism at school. There is limited evidence to guide practice in this area. The purpose of this study is to evaluate the efficacy of a sensory activity schedule (SAS) used in a school setting on task mastery and occupational performance in the classroom.

Design/methodology/approach
A randomised control trial (RCT) was conducted with 30 children to evaluate the efficacy of a school-based SAS. Children in the intervention group received SAS intervention and usual teaching. Children in the control group received only usual teaching. Outcome measures were the perceive, recall, plan and perform stage one procedural task analysis and goal attainment scaling.

Findings
Children in the intervention group demonstrated statistically significant improvements in school performance when compared with the control group in both outcome measures.

Research limitations/implications
This was a pilot study with small sample size, so results should be interpreted with caution. Further research is needed to replicate these findings.

Practical implications
A classroom-based SAS may have a positive effect on classroom performance for children with autism. This has implications for professionals who support children with autism and sensory processing difficulties in a school setting.

Originality/value
To the best of the authors’ knowledge, this study was the first of its kind in evaluating SAS intervention in a school setting using RCT methodology.
Hibiscus sabdariffa L. flower and date palm pollen fortification of date palm spathe beverage
Authors: ALTamimi Jozaa Z. , ALFaris Nora A. , Alghamdi Fatima Ail , Abu-Hiamed Hind A. , ALbadr Nawal A. , Almousa Lujain Abdulaziz 
Published: April 2020

PurposeThe purpose of this study is to investigate the effect of roselle flower extract and date palm pollen on the nutritional and sensory qualities of date palm spathe beverage (DPSB).Design/methodology/approachThe nutritional composition and sensorial quality of the date palm spathe-based beverage were evaluated. The product was fortified with different concentrations (1 per cent and 5 per cent) of roselle flowers and 1 per cent date palm pollen grains.FindingsGenerally, fortification of the DPSB with roselle flowers only or the combination of roselle flowers and date palm pollen grains significantly affected the nutritional and sensory properties of the products. The total dissolved solids, turbidity and total contents of proteins; fats; carbohydrates; vitamins A, E and C; iron; nickel and copper were highest in the DPSB fortified with a mixture of 1 per cent roselle flower extract and 1 per cent pollen grains and lowest in the DPSB supplemented with 1 per cent roselle flower extract. The manganese and selenium contents were both highest and lowest in DPSB supplemented with 5 per cent and 1 per cent roselle flower extract, respectively. Antioxidant activity was highest in DPSB supplemented with the 5 per cent roselle flower extract and lowest in unfortified DPSB. Boron, molybdenum and zinc contents were highest in unfortified DPSB. All sensory attributes were highest in both the unfortified DPSB and that fortified with 1 per cent roselle flower extract.Originality/valueWhile fortification with a combination of 1 per cent roselle flower extract and 1 per cent date palm pollen grains improved the nutritional quality of the DPSB, it negatively affected the sensory attributes of the products.
The gap in soft skills perceptions: a dyadic analysis
Authors: Tsirkas Konstantinos , Chytiri Alexandra-Paraskevi , Bouranta Nancy 
Published: April 2020

PurposePrevious studies have shown that soft skills play a significant role in applicants' employability and in the job search, recruitment, selection and hiring process. However, past research indicates a gap in perceptions of soft skills, between employees and employers. The present empirical research aims to explore this gap in perceptions and to suggest effective ways to resolve any mismatch. Demographical factors affecting these perceptions are also taken into consideration for the analysis.Design/methodology/approachA quantitative research design has been applied. The survey undertaken, covers all three main sectors of employment (manufacturing, retail and services), with 151 employee–employer dyads around Greece participating in the survey. Paired sample t-test, independent t-test and One-way ANOVA were used to analyze the data.FindingsThe results show a gap between employees' and their subsequent employers' perceptions of employees' soft skills. Employees seem to regard their skills more highly than do their employers, whereas employers seem to consider employees as not properly equipped with the necessary soft skills. These findings are a worrying sign for business operations and suggest that difficulties in manager–employee co-operation can arise.Practical implicationsThis study has both theoretical and practical implications. It adds to the literature in human resources appraisal process by identifying soft skills perceived differently by employees and employers. It also highlights the reasons for that gap and makes suggestions for the enhancement of required skills.Originality/valueThe majority of previous studies in the field focus either on employees' or employers' perceptions, without comparing them. In addition, the few former studies attempt a comparison focused on students as employees or trainees, with no previous work experience. The current study focuses on employees whose work experience has already shaped perceptions of their skills and employability.
Effects of CSR on employee retention via identification and quality-of-work-life
Authors: Kim Jungsun (Sunny) , Milliman John , Lucas Anthony 
Published: April 2020

PurposeThis paper aims to explore the sequential effects of employee perceptions of corporate social responsibility (CSR), organizational identification (OI), higher-order quality-of-work-life (HQWL) and intention to stay (IS).Design/methodology/approachThe survey responses were gathered from employees of a casino hotel company in the USA. All hypotheses were tested via structural equation modeling.FindingsThe results demonstrated that ethical and philanthropic CSR dimensions had significant direct effects on OI and indirect effects on HQWL via OI. OI had positive effects on HQWL (directly) and IS (directly and indirectly via HQWL). Both ethical and philanthropic CSR dimensions indirectly influenced IS via OI and HQWL, while economic CSR had a significant indirect effect on IS via HQWL.Research limitations/implicationsThis study addressed the lack of theory-driven empirical work on the relationship between CSR and employee retention by presenting new insights into how different dimensions of CSR can contribute for improving employee HQWL and IS via OI based on social identity theory (SIT) and social exchange theory (SET). In this study, the results may not generalize to other countries and cultures because the data arises from a casino hotel in the USA.Practical implicationsBased on the results, hospitality companies can improve employee OI, HQWL and IS by more effectively implementing different types of CSR programs.Originality/valueThis study provided support for the positive influence of CSR initiatives on hospitality employees in a controversial sector (i.e. casino hotels) in which there is a lack of empirical research.
Windows to the sold: verbo-visual multimodality in storefront windows
Authors: Lick Erhard , Bargenda Angela , Trabelsi Dhoha 
Published: April 2020

PurposeThe article seeks to enrich the body of research on store atmospherics by identifying how storefront window design impacts store entry decisions. An innovative multimodal design approach is presented, considering both visual and verbal constituents.Design/methodology/approachStudy 1 draws on a corpus of high-end storefront windows to create a categorization regarding different levels of verbo-visual complexity. The survey in Study 2 (n = 234) serves two purposes: first, to confirm these levels of complexity and second, to investigate the relation between the complexity of window design and store entry decisions.FindingsStudy 2 confirms the order of complexity established in Study 1. The results reveal an inverted-U relationship between window complexity and store entry propensity. Windows of medium level of complexity produce shoppers' relatively highest store entry propensity.Practical implicationsThe findings suggest that retailers would benefit from adopting verbo-visual window designs of medium complexity, as this combination optimizes the likeliness of consumers to enter stores.Originality/valueResearch on store atmospherics has until recently primarily focused on in-store cues. Studies on store windows remain vastly underrepresented in extant scholarship. The article not only fills this gap but also incorporates an original interdisciplinary angle on multimodality, which offers new methodological perspectives for research in retail and distribution scholarship.
Performance measurement of gas companies with fixed-sum inputs: a DEA-based model
Authors: Amirteimoori Hamzeh , Amirteimoori Alireza , Karbasian Mahdi 
Published: April 2020

PurposeThe paper analyzes the relative performance of provincial gas distribution companies with different types of inputs and outputs. A data envelopment analysis (DEA)-based model is developed to construct an equilibrium efficient frontier in the presence of multi-type input/output variables.Design/methodology/approachA DEA-based model is developed to construct an equilibrium efficient frontier in the presence of multi-type input/output variables.FindingsIt has been shown that using this single equilibrium efficient frontier, a trade-off is made between efficient and inefficient companies so as to make all companies as efficient.Originality/valueThe study analyzes the relative performance of provincial gas distribution companies with different types of inputs and outputs. A DEA-based model is developed to construct an equilibrium efficient frontier in the presence of multi-type input/output variables. It has been shown that using this single equilibrium efficient frontier, a trade-off is made between efficient and inefficient companies so as to make all companies as efficient.
Predicting managers' championing behavior through subordinates' change-related voice
Authors: Faupel Stefanie 
Published: April 2020

PurposeThe purpose of this paper is to determine whether managers who are not in top management perceive change-related voice from their work group as support and whether this perception is an explaining mechanism that can predict the managers' behavioral support for change. Such voice can be a valuable asset for managers during change.Design/methodology/approachLower and middle managers' perceptions of subordinates' support is investigated as mediator in the relationship between group change-related voice and managers' behavioral support for change. Seventy managers who were experiencing organizational change completed a survey at two points in time. Data were analyzed using regression analyses and the bootstrapping approach.FindingsManagers perceive promotive but not prohibitive group change-related voice as support. Perceived subordinate support serves as explaining mechanism in the relationship between promotive group change-related voice and managers' championing behavior.Practical implicationsThe study's results have practical implications, as insights are gained into how managers react to upward communication from the work group and how such communication influences managers' reaction to change. These insights can be used to facilitate effective participation during change, as it creates sensitivity to managers as recipients of change.Originality/valueResearch on how managers react to change-related ideas and concerns is scarce. The study extends current research on organizational change by investigating the impact of subordinates' communications on managers' reaction to change. Research on voice is enriched by focusing on the voice-receiving process.
Development and characterization of silk films for burn wound healing
Authors: Nachiappan Sukumar , Amanuel Lami , Agazie Tewodros , Bihonegn Seyoum 
Published: April 2020

Purpose
Wound healing is a dynamic process that relies on coordinated signaling molecules to succeed. Silk has proven to be a promising biomaterial for the development of a novel product. The purpose of the study is development of silk films, augmented functionality can be provided to silk by means of loading honey and recombinant human epidermal growth factor (rhEGF).

Design/methodology/approach
In this research work, the authors set out to explore possibilities of silk-based biomedical device development with particular attention to different fabrication strategies that can be leveraged for this purpose. They have produced a novel silk-based drug delivery material, in the form of silk films. Scanning electronic microscope was used to observe the morphology and the highly specific surface area. The structure was studied by Fourier-transform infrared spectroscopy. This methodology is accomplished using in vivo study data using Wister albonia rats.

Findings
The developed films also provided a significant higher healing rate in vivo, with well-formed epidermis with faster granulation tissue formation when compared to the controls. Biodegradable polymeric materials based on blending aqueous dispersions of natural polymer sodium alginate, Chitosan and rhEGF complex, which allow controlled antiseptic release, are presented.

Originality/value
These results suggest that silk-based controlled release of Chitosan-rhEGF may serve as a new therapy to accelerate healing of burn wounds.
Impact of bottle size on in‐home consumption of wine: a randomized controlled cross‐over trial
Authors: Codling Saphsa , Mantzari Eleni , Sexton Olivia , Fuller Georgia , Pechey Rachel , Hollands Gareth J. , Pilling Mark , Marteau Theresa M. 
Published: April 2020

AbstractAimTo assess the impact of purchasing wine in 50 cl bottles compared with 75 cl bottles on the amount of wine consumed at home.DesignCross‐over randomized controlled trial with a ‘usual behaviour’ period of a maximum of 3 weeks between conditions.SettingHouseholds in the United Kingdom.ParticipantsOne hundred and eighty‐six households that consumed between two and eight 75 cl bottles of wine each week.InterventionHouseholds were randomized to the order in which they purchased wine in two bottle sizes. During two 14‐day intervention periods, households purchased a pre‐set volume of wine—based on their baseline self‐reported weekly consumption—in either 75 cl bottles or 50 cl bottles. On days 7 and 14 of each study period, participating households sent photographs of each purchased wine bottle.MeasurementsThe primary outcome was the volume of study wine in millilitres (ml) consumed during each study period estimated through returned photographs. The secondary outcome was the rate of consumption measured by the mean number of days taken to drink 1.5 litres from each bottle size.FindingsOne hundred and sixty‐six of 186 enrolled households satisfactorily completed the study. After accounting for pre‐specified covariates, 191.1 ml [95% confidence interval (CI) = 42.03–339.2] or 4.5% (95% CI = 1.0–7.9%) more wine was consumed per 14‐day period from 75‐cl bottles than from 50‐cl bottles. Consumption was 5.8% faster (95% CI = –10.9 to –0.4%) from 75 cl bottles than from 50 cl bottles.ConclusionsConsuming wine at home from 50 cl bottles, compared with 75 cl bottles, may reduce both amount consumed and rate of consumption.
Do crop purchase programs improve smallholder welfare? The case of Zambia's Food Reserve Agency
Authors: Fung Winnie , Liverpool‐Tasie Lenis Saweda O. , Mason Nicole M. , Oyelere Ruth Uwaifo 
Published: April 2020

AbstractGovernment and parastatal crop purchase programs have regained popularity in sub‐Saharan Africa, with many citing improving smallholder farmers’ welfare as a key goal. Yet there is limited empirical evidence on the topic. This paper analyzes the effects of the Zambian Food Reserve Agency's (FRA's) maize purchase activities on smallholder welfare. The FRA buys maize at a pan‐territorial price that often exceeds market prices in surplus production areas. Using two household panel survey datasets spanning 15 years and exploiting variation in the scale of FRA activities over time, we employ fixed effects and control function approaches to estimate the effects of a smallholder household's maize sales to the FRA on its welfare, as well as the effects of more intense FRA maize purchase activity in a given district on the welfare of smallholder households in the district. Results suggest positive direct welfare effects on the minority of smallholders that sell to the FRA. We also find that, in the early years of the program, more intense FRA maize purchase activity in a district was associated with reductions in smallholder welfare, particularly among maize autarkic and net buying households. In later years, we find no evidence of such negative effects and some evidence of positive district‐level effects on maize net buyers.
Changes in treatment and mortality in men with locally advanced prostate cancer between 2000 and 2016: a nationwide, population‐based study in Sweden
Authors: Orrason Andri Wilberg , Westerberg Marcus , Garmo Hans , Lissbrant Ingela Franck , Robinson David , Stattin Pär 
Published: April 2020

ObjectiveTo evaluate whether the effects of radical treatment in men with locally advanced prostate cancer (PCa) on PCa mortality observed in randomised clinical trials are applicable on a population basis.Patients and methodsWe conducted a population‐based cohort study using the Prostate Cancer data Base Sweden of 20 350 men diagnosed between 2000 and 2016 with locally advanced PCa, defined as clinical local stage T3/T4, M0, Mx and a prostate‐specific antigen level of <100 ng/mL. Cumulative PCa mortality was examined using competing risk analysis of all men with locally advanced PCa, and also including men who did not undergo radical treatment. Multivariate regression analysis, including prognostic factors, was used to calculate hazard ratios (HRs) for all‐cause and PCa‐specific death.ResultsThe proportion of men treated with primary radical radiotherapy (n = 4174) or prostatectomy (n = 1210) increased from 15% in 2000–2003, 25% in 2004–2007, 33% in 2008–2011 to 43% in 2012–2016. The corresponding 5‐year PCa mortality decreased from 19%, 18%, 17%, to 15% for all men, with the steepest decrease in men aged 65–74 years, from 16% to 8%. The risk of PCa mortality in men aged <80 years was lower in the last period compared to the first period, with a HR of 0.65 (95% confidence interval 0.56–0.76) in multivariate analysis.ConclusionsThe threefold increase in use of radical treatment was accompanied by a modest decrease in PCa mortality in all men with newly diagnosed locally advanced PCa. For men aged 65–74 years, there was a 50% decrease in the relative risk of PCa death. This indicates that the benefits previously observed in randomised trials can also be achieved in a real‐life setting.