bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of the endocannabinoid system in the pathogenesis and treatment of epilepsy
Authors: Kosenkov Artem M. , Mal’tseva Valentina N. , Maiorov Sergei A. , Gaidin Sergei G. 
Published: December 2024

Abstract
Epilepsy is a group of chronic neurological brain disorders characterized by recurrent spontaneous unprovoked seizures, which are accompanied by significant neurobiological, cognitive, and psychosocial impairments. With a global prevalence of approximately 0.5–1 % of the population, epilepsy remains a serious public health concern. Despite the development and widespread use of over 20 anticonvulsant drugs, around 30 % of patients continue to experience drug-resistant seizures, leading to a substantial reduction in quality of life and increased mortality risk. Given the limited efficacy of current treatments, exploring new therapeutic approaches is critically important. In recent years, Gi-protein-coupled receptors, particularly cannabinoid receptors CB1 and CB2, have garnered increasing attention as promising targets for the treatment seizures and prevention of epilepsy. Emerging evidence suggests a significant role of the cannabinoid system in modulating neuronal activity and protecting against hyperexcitability, underscoring the importance of further research in this area. This review provides up-to-date insights into the pathogenesis and treatment of epilepsy, with a special focus on the role of the cannabinoid system, highlighting the need for continued investigation to develop more effective therapeutic strategies.
The hidden link: Investigating functional connectivity of rarely explored sub-regions of thalamus and superior temporal gyrus in Schizophrenia
Authors: Alahmadi Adnan , Al-Ghamdi Jamaan , Tayeb Haythum O. 
Published: December 2024

Abstract
Functional magnetic resonance imaging (fMRI) stands as a pivotal tool in advancing our comprehension of Schizophrenia, offering insights into functional segregations and integrations. Previous investigations employing either task-based or resting-state fMRI primarily focused on large main regions of interest (ROI), revealing the thalamus and superior temporal gyrus (STG) as prominently affected areas. Recent studies, however, unveiled the cytoarchitectural intricacies within these regions, prompting a more nuanced exploration. In this study, resting-state fMRI was conducted on 72 schizophrenic patients and 74 healthy controls to discern whether distinct thalamic nuclei and STG sub-regions exhibit varied functional integrational connectivity to main networks and to identify the most affected sub-regions in Schizophrenia. Employing seed-based analysis, six sub-ROIs – four in the thalamus and two in the STG – were selected. Our findings unveiled heightened positive functional connectivity in Schizophrenic patients, particularly toward the anterior STG (aSTG) and posterior STG (pSTG). Notably, positive connectivity emerged between the medial division of mediodorsal thalamic nuclei (MDm) and the visual network, while increased functional connectivity linked the ventral lateral nucleus of the thalamus with aSTG. This accentuated functional connectivity potentially influences these sub-regions, contributing to dysfunctions and manifesting symptoms such as language and learning difficulties alongside hallucinations. This study underscores the importance of delineating sub-regional dynamics to enhance our understanding of the nuanced neural alterations in Schizophrenia, paving the way for more targeted interventions and therapeutic approaches.
Translation, Cultural Adaptation, and Validation of the Multidimensional Scale of Perceived Social Support for Cancer Patients in Indonesia
Authors: Setiawan Didik , Muamala Anisa , Juwita Dina Ratna , As Suaidy Bustanuddin , Perwitasari Dyah Aryani , Lianawati Lianawati 
Published: December 2024

The social support is increasingly accepted as an important factor that influences the wellness of a human being, particularly people with chronic diseases. This study translates and validates the quantitative questionnaire that has been developed and has been widely accepted across cultures, namely the Multidimensional Scale of Perceived Social Support (MSPSS). The study was initially performed by translating the original questionnaire using forward and backward translation methods. Thirty cancer patients from Margono public hospital Purwokerto, Indonesia were conveniently included to evaluate the transleted questionmaire’s cconvergent, discriminant validity. Furthermore, 45 cancer patients were included in the main study which evaluate the level of social support among cancer patients. According to factor analysis, Kaiser-Meyer-Olkin Measure of Sampling Adequacy showed that the results is valid (0.668) while the Bartlett’s Test of Sphericity also showed that the number of samples were adequate (0.668) and eligible for factor analysis. The Measures of Sampling adequacy from each question was considerably higher than 0.5 and therefore there were no translated question that has to be removed in the analysis. There were 3 out of 12 factors that was included with the total variance of 81.166%. The Pearson’s correlation and Cronbach Alpha tests showed that discriminant validity and reliability test of the translated questionnaire were valid (>0.400) and reliable (>0.700) questionnaire. The translated version of the MSPSS was considerably a valid and reliable questionnaire to evaluate the level of social support for cancer patients in Indonesia.
Characteristics and Resource Utilization of Hospitalized Children With Somatic Symptoms
Authors: Roelf Kelly , Khare Manaswitha , Rungvivatjarus Tiranun , Mannino Avila Elizabeth , Lenzen Christiane , Patel Aarti , Fisher Erin Stucky , Cameron Melissa 
Published: December 2024

OBJECTIVE
To examine patient characteristics and resource utilization of hospitalized children and adolescents with somatic symptom and related disorders (SSRDs).

PATIENTS AND METHODS
This study included 173 patients who were aged 6 to 18 years and admitted to a single, tertiary academic children’s hospital between April 2015 and December 2021 with a diagnosis of an SSRD. Sociodemographic information and clinical features were assessed as outcomes. Resource utilization was compared across diagnostic subgroups. Regression analysis was used to determine whether diagnosis predicted length of stay (LOS).

RESULTS
Of the 173 patients included, presenting symptoms were primarily neurologic (n = 109, 63%); the most common diagnostic subgroup was functional neurologic symptom disorder (n = 65, 38%). Resource utilization was notable; the median laboratory studies ordered was 9 (IQR, 4.5–13), 119 of the 173 patients (69%) had at least 1 imaging study, and 124 (72%) had at least 1 physician consultation. The 14-day all-cause emergency department (ED) return rate was 20% (n = 35), and 14-day related ED return rate was 16% (n = 27). After adjustments, LOS was significantly associated with physician-ordered labs (β = 0.32; P = &lt;.001) and consults (β = 0.41; P = &lt;.001).

CONCLUSION
The findings of this study revealed significant variability in the management of hospitalized patients diagnosed with SSRDs. Future studies to assess the benefit of clinical pathways for SSRDs to standardize management and potentially reduce health care cost by limiting unnecessary evaluation are needed.
Developing a deeper understanding of actionable customer feedback: A systematic literature review
Authors: Molnár László , Keszey Tamara , Frau Moreno 
Published: December 2024

AbstractThis paper aims to enhance the understanding of the influencing factors and consequences of feedback, with a particular focus on brand outputs and co-creation, and to identify future research areas related to feedback. First, we propose to clarify definitions by introducing actionable customer feedback and drawing clear distinctions among synonymic concepts used in the literature. Then, we conduct a systematic literature review of 73 journal articles from the past two decades and synthesize their findings in the feedback, brand, and co-creation intercept. We also introduce a structure for feedback-related antecedents, moderators, mediators, and performance outputs. As a main contribution, we offer a visual representation of the findings of the systematic literature review to support scholars of customer behavior who are discovering their own directions according to their expertise. Through the use of visual tools such as tables and figures, we provide summary statistics reflecting the methodologies used in the literature, the industries involved, the geographical spread, and adjacent theories used. We also summarize the different positions of feedback within conceptual frameworks. We contribute to the literature by proposing and visually demonstrating new grouping dimensions of the antecedents, mediators, moderators and performance outcomes of the feedback literature. Finally, we recommend directions for future research on actionable feedback. We recommend studying the mediating and moderating impacts of demographics, gender, environmental characteristics, geography (especially developing economies), and B2B businesses on actionable feedback. The roles of trust and feedback in brand outputs, for example, brand value and brand equity, requires further investigation. Finally, we recommend exploring constructs in which feedback plays multiple roles in different positions.
Miguel de Baeza: <i>Los Cuatro libros del arte de la confitería</i> & Joaquín Gacén, <i>Manual de Repostería</i>
Authors: Hayward Vicky 
Published: December 2024

Miguel de Baeza: Los Cuatro libros del arte de la confitería (1592), intro. by M. García Ruipérez and M. del Prado Olivares Sánchez: Antonio Pareja, Editor, 2014: 161 pp., paperback.
Joaquín Gacén, Manual de Repostería (1804-07), ed. by S. Gómez Laguna: Institución Fernando el Católico, Zaragoza, 2000: 112 pp., paperback.
Charles Elmé Francatelli, Additions & Supplementations
Authors: Smythe Colin 
Published: December 2024

This article continues the author's account of the career of C.E. Francatelli begun in PPC 101. This particular contribution consists of material concerning the milieu in which Francatelli operated, particularly details about the gaming club Crockford's and changes at the Reform Club after the departure of Soyer.
Nanofibrous carbon (multi-wall carbon nanotubes): synthesis and electrochemical studies by using field-effect transistor setup
Authors: Mustafin Ildar A. , Akhmetov Arslan F. , Salikhov Renat B. , Mullagaliev Ilnur A. , Salikhov Timur R. , Galiakhmetov Rail N. , Shabunina Olga V. , Kopchuk Dmitry S. , Kovalev Igor S. , Mustafin Akhat G. 
Published: December 2024

Synthesis of nanofibrous carbon (multi-wall carbon nanotubes, MWCNTs) by means of n-hexane pyrolysis is reported. The structure of the obtained MWCNTs was studied using scanning electron microscopy, and the diameters of 20–85 nm and lengths of 500–600 nm for these nanotubes were observed. By using the above mentioned MWCNTs field-effect transistors were fabricated on ITO glass substrates with a gate dielectric made of 390 nm thick Al2O3 foil and the drain-source contacts made of 300 nm thick aluminum foil. The Nano-C film 200 nm thick was deposited by thermal evaporation in vacuum. The properties of the obtained field-effect transistors were studied. The current-voltage characteristics of the OFET show an increase in currents with a positive voltage on the gate, which corresponds to the electron conductivity of the transport channel. The dependences are nonlinear, and there are no saturation regions in the output characteristics. The Raman spectra indicate the presence of nickel and show characteristic peaks for C=C and CH bonds.
Effect of dissolved oxygen on the efficiency of the electro-Fenton process on Fe2O3/graphite perforated tubular electrode
Authors: Isaev Abdulgalim , Alimirzoeva Zarema , Isaeva Maryam , Kharlamova Tatyana 
Published: December 2024

Electrodes based on carbon materials modified with iron oxides or metallic iron have attracted much attention in the field of heterogeneous electro-Fenton process for the removal of various organic pollutants. In this study, perforated tubular graphite electrode modified with Fe2O3 (Fe2O3/GT) by electrochemical deposition was used as a cathode material. The obtained electrode was characterized by electron microscopy, energy-dispersive spectroscopy and Raman spectroscopy. The oxidation of rhodamine B in the electro-Fenton process by bubbling air through the perforated tubular graphite cathode at different air pressures was investigated. The complete decolorization of the rhodamine B solution was achieved in 20 min of electrolysis using Fe2O3/GT as a cathode at a current density of 29.85 mA/cm2 and a pressure of 0.1 MPa. The use of higher pressure leads to complications in the equipment design of the electro-Fenton process. Carrying out the electro-Fenton process at a pressure of 0.6 MPa leads to a decrease in the energy consumption by 0.07 kW×h/mg. A possible mechanism for the oxidation of rhodamine B by bubbling air through the perforated tubular graphite cathode modified with Fe2O3 was proposed.
Property Investment Measurement (IAS 40) And Quality of Financial Statements of Listed Pharmaceutical Firms in Nigeria
Authors: Olalekan Fadairo Ibukun , Siyanbola Tunji Trimisiu , Aderibigbe Amos Adejare , Oyewunmi Adenike Abibat 
Published: December 2024

Pharmaceutical companies in Nigeria encounter several unique challenges when applying IAS 40 for the measurement of investment properties. These challenges are largely due to the complexity of the standards, management's potential manipulation of financial results, and Nigeria's unique economic and regulatory context. This study investigated the impact of investment property measurement under IAS 40 on the financial reporting quality of listed pharmaceutical companies in Nigeria. A cross-sectional survey design was employed, collecting data from selected pharmaceutical companies using structured questionnaires. The study analyzed responses from 95 employees through multiple regression analysis with SPSS 25. The results indicated that the cost method had a positive insignificant effect on the reliability of financial statements (β1 = 0.009; p = 0.532 > 0.05). In contrast, the fair value method for measuring investment property demonstrated a positive and significant effect on the reliability of financial statements in Nigerian pharmaceutical companies (β2 = 0.203; p = 0.032 < 0.05). Similarly, while the cost method had a positive effect on the comparability of financial statements (β1 = 0.051), this relationship was not statistically significant (p = 0.423 > 0.05). However, the fair value method showed a significant positive effect on the comparability of financial statements (β2 = 0.355; p = 0.017 < 0.05). The study recommends that Nigerian pharmaceutical firms adopt the fair value method for measuring investment properties to enhance financial statement reliability and comparability, promoting more transparent and accurate financial reporting.
O caminho para o tratamento de fraturas de quadril em idosos: uma revisão integrativa de estudos qualitativos
Authors: Vasconcelos Caio Brandao e , Loyola Cristina Maria Douat , Coan Fernanda Fernandes , Campelo Sabrina de Sousa 
Published: December 2024

Trata-se de uma revisão integrativa que busca estudos qualitativos na literatura que abordem as subjetividades de pacientes idosos com fraturas do quadril em rota para tratamento cirúrgico. A revisão do processo baseou-se nas recomendações da lista de conferência do Rayyan Enterprise, Faster Systematic Review (“Rayyan - AI Powered Tool for Systematic Literature Reviews”, 2021). Foram examinados artigos publicados entre 1976 e 2023 que fizessem estudo qualitativo relacionado à fratura de quadril em idosos. As buscas ocorreram em Julho de 2023 nas bases de dados PubMed, MEDLINE, Scopus e Web of Science. A seleção compreendeu três etapas: busca, pré-seleção e inclusão de artigos. Foram utilizados os seguintes descritores em ciências da saúde (DeCS): (hip fracture) AND (elderly) AND (qualitative). Foram identificados 665 artigos nas bases de dados pesquisadas através das estratégias de busca. Após leitura dos títulos e resumos, 12 artigos foram considerados potencialmente elegíveis para inclusão no estudo e foram recuperados para leitura na íntegra. Após a leitura completa, os 6 artigos foram selecionados mediante aplicação dos critérios de inclusão e exclusão estabelecidos. Fluxograma da seleção de estudos sobre fratura de quadril em idosos: pesquisas qualitativas publicadas entre 1976 a 2023. O caminho para o tratamento da fratura tem se mostrado uma experiência muito desagradável, que piora pela falta de informação, pelo tédio relacionado à demora para o tratamento, pela falta de participação do paciente nas tomadas de decisão e pela insegurança na equipe.
Dueto Ja Ne e Steve Lá
Authors: Fenerich Alexandre Sperandéo 
Published: December 2024

O texto trata de duas peças do compositor Rodolfo Caesar, Dueto Je Ne e Steve Lá, construídas a partir do procedimento do compositor norte-americano Steve Reich da micro-defasagem entre trilhas de áudio. Apesar de utilizar da mesma técnica, todavia, Caesar cria outros sentidos, seja a partir da relação deste procedimento com os materiais de origem, seja, no caso de Steve Lá, por acoplar imagens visuais ao substrato sonoro. Os sentidos criados com o material apropriado pelo compositor - a voz do artista Joseph (caso de Dueto Ja Ne) e imagens e a música do DVD Broadway (caso de Steve Lá) serão analisados. Finalmente, será marcada a vinculação do Dueto Ja Ne a um desenho do artista visual Milton Machado que possui caráter de uma partitura, de cuja leitura proveio a ideia de apropriação do procedimento de Reich.
A COMPARATIVE STUDY OF THE PRODUCTION COSTS OF HYDROPHOBIC OINTMENTS, HYDROPHILIC OINTMENTS, AND GELS IN RELATION TO DRUG FORMULATION STABILITY
Authors: Rachmat Rd.Lutpi , Al Arif Moh. Anam , Hidanah Sri , Lokapirnasari Widya Paramita 
Published: December 2024

Povidone – iodine has antiseptic properties for wound healing. This research makes antiseptic preparations in semi-solid dosage form with different bases used. This research aims to find out whether the different bases in the formula used can affect its stability and how much it costs for each formula. Formula 1 with a hydrocarbon base, formula 2 with a hydrophilic base, formula 3 gel with a Na-CMC base. The stability of the three formulas was observed using the freeze - thaw method with different temperatures for 18 days of storage and observed organoleptically, homogeneity, spreadability, pH viscosity and then processed using one way ANOVA and I-MR control charts. The research results showed that the different bases in the formula had a significant effect on the spreadability, pH and viscosity values ​​with a significant value of 0.000. Differences in formula also affect organoleptic results and homogeneity. Formula 2 has the best stability based on the results of the tests carried out. In terms of costs, Formula 2 has greater raw material costs compared to Formula 1 and Formula 3.

Keywords: Antiseptic, cost and stability
Synergistic effect of AP/KP composite oxidizers prepared by electrostatic spraying and promotion of aluminum combustion performance
Authors: Sun Sen , Li Shengwei , Wang Yuanjing , Zhou Jinqiang , Pan Qi , Wu Chengcheng , Guo Xueyong 
Published: December 2024

Abstract

In order to solve the problems of low effective oxygen content, low density and high mechanical sensibility of ammonium perchlorate (AP) for propellant, potassium perchlorate (KP), which has a higher density and greater effective oxygen content, was introduced. An AP/KP composite oxidizer was prepared using electrostatic spraying. The morphology, structure, thermal properties, safety, and combustion performance of the samples were characterized using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), and a quadruple coupling technique (TG-DSC-FTIR-MS). Comparative studies were performed with raw materials and physically mixed samples. The results indicate that the crystal structures of AP and KP remained unchanged in the composite oxidizers prepared using different methods. The electrostatic spray samples exhibited significantly improved safety compared to raw AP and physically mixed samples, with friction sensitivity reduced by 36% and 16%, respectively. Thermal analysis revealed that the electrostatic spray samples significantly enhanced the high-temperature decomposition of AP and KP, with decomposition peaks reduced by 49.15°C and 9.67°C, respectively. Additionally, the electrostatic spray method significantly reduced the activation energy of KP's thermal decomposition from 444.34–436.84 kJ·mol− 1 to 225.07–228.28 kJ·mol− 1. Compared to raw and physically mixed samples, the electrostatic spraying method reduced the ignition delay time of the composite oxidizer, increased the aluminum powder combustion rate, and enabled complete combustion of the Al powder. The electrostatic spraying method, with its adjustable process parameters and controllable sample morphology, enhances the overall performance of the composite oxidizer.
Enhanced rGO/ZnO/Chitosan Nanozyme Photocatalytic Technology for Efficient Degradation of Diazinon Pesticide Contaminated Water
Authors: Hamid Fitri Handayani , Rasyid Fathur Rizqa , Mashuni Mashuni , Ahmad La Ode , Jahiding M 
Published: December 2024

Abstract

The increasing presence of pesticide contaminants in water bodies poses significant environmental and health challenges. This study introduces a novel enzyme-based photocatalytic technology composed of reduced graphene oxide (rGO), zinc oxide (ZnO), and chitosan (CS) designed to enhance the degradation efficiency of diazinon pesticides in polluted water. The nanozymes were characterized by XRD, SEM-EDX, and FTIR to ensure homogeneous structure and distribution of the materials, and the adsorbed pesticide content was measured using a UV-Vis spectrophotometer. Adsorption studies showed that the diazinon removal efficiency increased with higher pH, longer contact time, and initial concentration, reaching maximum adsorption efficiency at neutral pH. Isotherm analysis showed that diazinon adsorption on rGO/ZnO/CS nanozymes followed the Freundlich model, exhibiting heterogeneous adsorption characteristics with moderate adsorption capacity. These findings highlight the potential of rGO/ZnO/CS nanozymes as effective adsorbents for removing diazinon pesticides from contaminated water, offering promising applications in environmental remediation.
Altered spike dynamics drives immune evasion of SARS-CoV-2
Authors: Saksela Kalle , Ugurlu Hasan , Salminen Petja , Yuan Meng , Fagerlund Riku , Mäkelä Anna , Zusinaite Eva , Kesti Tapio , Rissanen Ilona , Merits Andres , Wilson Ian 
Published: December 2024

Abstract

Rapid viral escape from protective immunity has been an unwanted hallmark of the COVID-19 pandemic. This escape has been attributed to mutations in critical neutralizing antibody epitopes mainly in the receptor binding domain (RBD) of the viral spike glycoprotein. Here we show that this notion is incomplete. We found that several broadly neutralizing human antibodies isolated over the past years retain an almost undiminished capacity for inhibitory targeting of RBDs of recent highly immunoevasive SARS-CoV-2 strains. Likewise, human sera collected during the pre-Omicron era from persons immunized with original Wuhan-based vaccines were found to contain abundant neutralizing activity targeted against the RBDs of modern Omicron variants. However, this unexpected neutralization sensitivity was observed only when these RBDs were incorporated into a mismatched spike protein backbone, whereas the corresponding native Omicron spike proteins were highly resistant against the same panel of antibodies and human sera. We conclude that changes occurring outside of the RBD and leading to altered conformational dynamics of the spike protein have played a key part in the viral evolution enabling SARS-CoV-2 to escape from neutralizing antibodies that target highly conserved cryptic RBD epitopes.