bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rectal Microbiome Alterations Associated With Oral Human Immunodeficiency Virus Pre-Exposure Prophylaxis
Authors: Fulcher Jennifer A , Li Fan , Cook Ryan R , Zabih Sara , Louie Alexander , Okochi Hideaki , Tobin Nicole H , Gandhi Monica , Shoptaw Steven , Gorbach Pamina M , Aldrovandi Grace M 
Published: October 2019

Abstract

Background
Oral daily tenofovir (TFV) disoproxil fumarate/emtricitabine (TDF/FTC) for human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) is highly effective for HIVprevention, yet long-term effects are not fully understood. We investigated the effects of PrEP on the rectal microbiome in a cohort of men who have sex with men (MSM).

Methods
This cross-sectional analysis included HIV-negative MSM either on PrEP (n = 37) or not (n = 37) selected from an ongoing cohort using propensity score matching. Rectal swabs were used to examine microbiome composition using 16S ribosomal ribonucleic acid gene sequencing, and associations between PrEP use and microbiota abundance were examined. Hair specimens were used to quantify TFV and FTC exposure over the past 6 weeks on a subset of participants (n = 15).

Results
Pre-exposure prophylaxis use was associated with a significant increase in Streptococcus abundance (adjusted P = .015). Similar associations were identified using least absolute shrinkage and selection operator (LASSO) regression, confirming the increase in Streptococcus and also showing increased Mitsuokella, Fusobacterium, and decreased Escherichia/Shigella. Increased Fusobacterium was significantly associated with increasing TFV exposure.

Conclusions
Oral TDF/FTC for PrEP is associated with rectal microbiome changes compared to well matched controls, specifically increased Streptococcus and Fusobacterium abundance. This study highlights the need for future investigations of the role of microbiome changes on HIV susceptibility and effectiveness of PrEP.
Rapid generation of sequence-diverse terminator libraries and their parameterization using quantitative Term-Seq
Authors: Hudson Andrew J , Wieden Hans-Joachim 
Published: October 2019

Abstract
Synthetic biology and the rational design and construction of biological devices require vast numbers of characterized biological parts, as well as reliable design tools to build increasingly complex, multigene architectures. Design principles for intrinsic terminators have been established; however, additional sequence-structure studies are needed to refine parameters for termination-based genetic devices. We report a rapid single-pot method to generate libraries of thousands of randomized bidirectional intrinsic terminators and a modified quantitative Term-Seq (qTerm-Seq) method to simultaneously identify terminator sequences and measure their termination efficiencies (TEs). Using qTerm-Seq, we characterize hundreds of additional strong terminators (TE &gt; 90%) with some terminators reducing transcription read-through by up to 1000-fold in Escherichia coli. Our terminator library and qTerm-Seq pipeline constitute a flexible platform enabling identification of terminator parts that can achieve transcription termination not only over a desired range but also to investigate their sequence-structure features, including for specific genetic and application contexts beyond the common in vivo systems such as E. coli.
Delivery of a smoking cessation induction intervention via virtual reality headset during a dental cleaning
Authors: Borrelli Belinda , Rueras Nicolle , Jurasic Marianne 
Published: October 2019

Abstract
Smokers who are not motivated to quit are less likely to seek help or utilize medication for cessation, so it is critical to proactively reach them to motivate cessation. This study aims to determine feasibility and satisfaction of a smoking cessation induction intervention via a virtual reality (VR) headset worn during dental cleaning. Participants (n = 23) were adult dental patients who were current smokers. During their teeth cleaning, participants wore a VR headset to watch two 5-min smoking cessation videos, one targeted to smokers who are not ready to quit and one for those who are ready to quit. Questionnaires were administered pre- and postappointment, and 1 month later. Interviews were conducted immediately after the appointment. Implementation did not interfere with care delivery, including instrument manipulation and patient–provider communication. On a 1–7 scale, participants indicated satisfaction with the experience (M = 5.4, SD = 1.3), and a positive impact on their willingness to quit (15 of 22 rated ≥ 6) and their knowledge of the effects of smoking on their health (22 of 23 rated as ≥ 6). Participants were highly satisfied with the video content (M = 4.3; 1–5 scale). When prompted, 82.6% were able to recall three things from the video. One month later, four to five participants reported that they quit smoking (varied by measure) and 14 of 23 intentionally quit smoking ≥ 24 hr. Among nonquitters, motivation to quit increased from baseline to follow up. This study may help guide the integration of virtual reality headset use in the dental setting to promote smoking cessation regardless of motivation to quit.
Contact Sensitization in Patients with Chronic Leg Ulcers: Results of a 5-Year Retrospective Analysis
Authors: Raudonis Tadas , Vankeviciute Rasa Aurelija , Lideikaite Andre , Grigaityte Anna Greta , Grigaitiene Jurate 
Published: October 2019

ABSTRACTOBJECTIVESTo determine the frequency of contact sensitization among patients with chronic leg ulcers; to identify the most common allergens; and to examine possible relationships to ulcer duration, itching, exudate, and leg eczema.METHODSResearchers conducted a 5-year retrospective analysis of 145 patients diagnosed with chronic leg ulcers who underwent skin patch testing with S-1000, LU-1000, and the commonly used dressing and antiseptic series.RESULTSInvestigators included 88 females (60.7%) aged 64 ± 15.1 years and 57 males (39.3%) aged 61 ± 16.4 years. Of these, 62.8% (n = 91) of patients were sensitized to at least one substance (2.6 ± 1.4 allergens on average). The most common allergens were benzalkonium chloride (18.6% [n = 27]), balsam of Peru (17.9% [n = 26]), and povidone-iodine 10% (17.2% [n = 25]). Finally, 40% (n = 58) of patients presented with pruritus around the ulcer, which was strongly associated with a positive patch test reaction (74.1% [n = 43] vs 55.2% [n = 48];P= .021) and polysensitization (3.5 sensitivities [95% confidence interval, 2.4–4.6] vs 2 [95% confidence interval, 1.2–2.8]).CONCLUSIONSContact sensitization is very common in patients with chronic leg ulcers, and pruritus around the ulcer is associated with contact allergy as well as polysensitization.
Cochlear Enhancement May Precede Cochlear Obliteration After Vestibular Schwannoma Excision
Authors: Erbele Isaac D. , Miller Laura S. , Mankekar Gauri , Morel Christian E. , Anderson Dwayne T. , Son Leslie S. , Arriaga Moises A. 
Published: October 2019

Objective:
Cochlear obliteration after vestibular schwannoma excision has been noted, with implications on cochlear implantation. Early postoperative cochlear enhancement with gadolinium on magnetic resonance imaging (MRI) has also been observed. Timing of enhancement and association with obliteration is described here.

Study Design:
Retrospective case review.

Setting:
Tertiary referral center, ambulatory.

Patients:
Patients receiving vestibular schwannoma excision surgery by the senior author performed at one institution between January 2015 and July 2017 with postoperative MRIs

Intervention:
Diagnostic.

Main Outcome Measure(s):
The imaging characteristics on postoperative MRIs examined were loss of fluid signal on postoperative T2 images and cochlear enhancement on gadolinium enhanced T1 images. In the patients receiving labyrinthine sparing procedures, presence of postoperative hearing was evaluated.

Results:
Of the 42 patients evaluated, 24 received the translabyrinthine approach and 18 received a labyrinth sparing surgery. Twenty-nine had evidence of cochlear enhancement on T1 with gadolinium contrast, and 27 had evidence of cochlear obliteration on T2 images. The odds ratio of patients with cochlear enhancement having obliteration was 30.0:1 (p < 0.0001). Intense cochlear enhancement (n = 21) appeared a median of 163 days after surgery, and complete or near complete obliteration (n = 18) appeared a median of 480 days after surgery, a statistically significant difference (p < 0.001). Within the labyrinth sparing group, there was no statistically significant association between hearing loss and cochlear obliteration or enhancement.

Conclusions:
Cochlear enhancement is correlated with cochlear obliteration and may precede it.
Hemodynamic Changes in the Sigmoid Sinus of Patients With Pulsatile Tinnitus Induced by Sigmoid Sinus Wall Anomalies
Authors: Liu Zhaohui , He Xueying , Du Runshuang , Wang Guopeng , Gong Shusheng , Wang Zhenchang 
Published: October 2019

Objective:
This study is to investigate the hemodynamic changes of pulsatile tinnitus (PT) patients induced by sigmoid sinus wall anomalies (SSWA).

Study Design:
Prospective study.

Setting:
Tertiary referral university hospital.

Patients:
Fifteen unilateral PT patients with SSWA identified on computed tomography images and surgery and 15 age-, sex-, and body mass index-matched healthy volunteers underwent velocity-encoded, cine magnetic resonance imaging.

Intervention:
Hemodynamic data in sigmoid sinus were obtained from velocity-encoded, cine magnetic resonance imaging, and compared between PT patients and controls.

Main Outcome Measures:
Heart rate was recorded. Cross-sectional area (CSA), peak positive velocity (PPV), average positive flow volume per beat (APFV/beat), average flow volume per beat (AFV/beat), peak negative velocity (PNV), and average negative flow volume per beat (ANFV/beat) were measured. Average flow volume per minute (AFV/min), average positive flow volume per minute (APFV/min), average negative flow volume per minute (ANFV/min), average positive velocity (APV), average negative velocity (ANV), and regurgitation fraction (RF) were calculated.

Results:
APV at PT side of patients was 13.4 ± 3.3 cm/s, which was significantly slower than that at corresponding side of controls (15.8 ± 2.6 cm/s). PNV and RF at PT side of patients were 21.0 ± 15.4 cm/s and 2.4% respectively, which were significantly higher than those values at corresponding side of controls (both of them were 0). HR, CSA, PPV, APFV/beat, APFV/min, AFV/beat, AFV/min, ANV, ANFV/beat, and ANFV/min were 69.8 ± 9.4 beat/min, 48.4 ± 17 mm2, 31.4 ± 5.9 cm/s, 5.4 ± 1.8 ml/beat, 373.9 ± 117.7 ml/min, 5.1 ± 2.0 ml/beat, 352.0 ± 134.6 ml/min, 2 (0–4.9) cm/s, 1 (0–2.7) ml/beat, and 4.1 (0–141.3) ml/min at PT side of patients, and 67.4 ± 7.8 beat/min, 38.2 ± 18 mm2, 29.9 ± 3.9 cm/s, 5.3 ± 2.0 ml/beat, 350.3 ± 125.3 ml/min, 5.1 ± 1.9 ml/beat, 340.5 ± 117.9 ml/min, 0 (0–2.1) cm/s, 0 (0–0.8) ml/beat, and 0 (0–55.4) ml/min at corresponding side of controls. These hemodynamics were not significantly different between groups.

Conclusion:
APV, PNV, and RF changes take place in SSWA patients, which may be associated with the occurrence of PT and have the potential value to improve accurate etiological diagnosis and predict treatment success.
Using critical realism in critical accounting research – a commentary by two ANTs
Authors: Baxter Jane , Chua Wai Fong 
Published: October 2019

PurposeThe purpose of this paper is to respond to Modell’s arguments regarding the relative usefulness of critical realist philosophy in relation to actor-network theory.Design/methodology/approachThe authors outline the challenges in applying critical realism to critical accounting. The authors then consider Modell’s criticisms of actor-network theory, providing a counterargument highlighting the methodological choices distinguishing actor-network theory from critical realism.FindingsThe authors argue that critical realism, whilst providing an interesting addition to the critical accounting research project, confronts challenges disentangling intransitive and transitive forms of knowledge. Actor-network theory is presented as a way of examining accounting practices as local associations, providing practical opportunities to study (the assembly of) “the social”.Research limitations/implicationsMethodological diversity is to be explored, acknowledging the ontological politics of our choices.Originality/valueThis paper is an original commentary contributing to critical accounting research.
Implementation and user acceptance of research information systems
Authors: Schöpfel Joachim , Azeroual Otmane , Saake Gunter 
Published: October 2019

Purpose
The purpose of this paper is to present empirical evidence on the implementation, acceptance and quality-related aspects of research information systems (RIS) in academic institutions.

Design/methodology/approach
The study is based on a 2018 survey with 160 German universities and research institutions.

Findings
The paper presents recent figures about the implementation of RIS in German academic institutions, including results on the satisfaction, perceived usefulness and ease of use. It contains also information about the perceived data quality and the preferred quality management. RIS acceptance can be achieved only if the highest possible quality of the data is to be ensured. For this reason, the impact of data quality on the technology acceptance model (TAM) is examined, and the relation between the level of data quality and user acceptance of the associated institutional RIS is addressed.

Research limitations/implications
The data provide empirical elements for a better understanding of the role of the data quality for the acceptance of RIS, in the framework of a TAM. The study puts the focus on commercial and open-source solutions while in-house developments have been excluded. Also, mainly because of the small sample size, the data analysis was limited to descriptive statistics.

Practical implications
The results are helpful for the management of RIS projects, to increase acceptance and satisfaction with the system, and for the further development of RIS functionalities.

Originality/value
The number of empirical studies on the implementation and acceptance of RIS is low, and very few address in this context the question of data quality. The study tries to fill the gap.
Exploring oppositional loyalty and satisfaction in firm-hosted communities in China
Authors: Liang Ruoyu , Guo Wei , Zhang Linghao 
Published: October 2019

Purpose
An increasing number of companies have become aware of the considerable commercial potential of firm-hosted online communities (FOC) and initiated their own platform for different purposes. However, limited research has systematically explored oppositional loyalty and customer satisfaction in the context of FOC. By applying the expectation–confirmation model (ECM), the purpose of this paper is to investigate the determinants of oppositional loyalty and satisfaction from the perspective of social capital and e-quality.

Design/methodology/approach
A research model was tested by applying partial least squares technique, and data were collected from a survey of members (n=512) of two popular smartphone communities in China.

Findings
Results revealed that satisfaction, trust and shared language are the significant antecedents of oppositional loyalty. Benefits confirmation, information quality, service quality, trust and social tie exert strong effects on the formation of satisfaction.

Originality/value
This study is an original empirical research guided by several theories. It contributes to the information system usage literature and provides opinions regarding how users’ oppositional loyalty and satisfaction can be developed in the FOCs. This work also widens the application of ECM and provides an alternative theoretical framework for future research on oppositional brand loyalty.
Attributions of victim responsibility in revenge pornography
Authors: Gavin Jeff , Scott Adrian J. 
Published: October 2019

Purpose
Revenge pornography is a growing risk among adolescents and young adults. Often stemming from sexting, some victims of revenge pornography report experiencing victim-blame similar to that accompanying the reporting of rape. The purpose of this paper is to explore the assumptions that underlie attributions of victim-blame, with a focus on perpetrator and victim responsibility, as well as gendered assumptions surrounding sexting.

Design/methodology/approach
A total of 222 UK university students (111 male, 111 females) read one of two versions of a hypothetical revenge pornography scenario, one involving a male victim of a female perpetrator, the other a female victim of a male perpetrator. They then responded to an open-ended question regarding responsibility.

Findings
Qualitative content analysis of these responses identified three inter-related themes: the victim’s behaviour, mitigating victim responsibility and minimising the behaviour.

Social implications
The majority of participants in this study attributed at least some responsibility to the victims of revenge pornography depicted in the scenarios. Sex of the victim played a less important role than assumptions around sexting.

Originality/value
The study suggests that victim-blame is linked to the consent implied by sharing intimate images with a partner, but is also mitigated by the normative nature of this relationship practice. There was some evidence that the experience of male victims of revenge pornography is trivialised. These findings have implications for e-safety and victim support.
A systematic review of AACSB International accreditation quality and value research
Authors: MacKenzie Jr William I. , Scherer Robert F. , Wilkinson Timothy J. , Solomon Norman A. 
Published: October 2019

Purpose
The purpose of this paper is to conduct a systematic review of the research on the quality and value of AACSB International accreditation.

Design/methodology/approach
Data were abstracted from published journal articles between 2003 and 2017 in which the words “AACSB” and “quality” or “value” (or both quality and value) were used in the title or the article text.

Findings
In total, 91 studies were identified that have been published on the value and/or quality of AACSB accreditation. These studies focused primarily on students and faculty and were conducted using survey research methods. Results indicate that accreditation does have some effects on stakeholder value and quality.

Research limitations/implications
While there is evidence to support the importance of accreditation to enhance the quality and value of business schools, additional research is needed to empirically support the quality and value propositions.

Practical implications
In order to effectively communicate to stakeholders how AACSB accreditation enhances the business school, the current study’s findings indicate that identification of indicators and factors that affect quality and value would be productive.

Originality/value
This study contributes insight on what is currently known about the quality and value of AACSB accreditation to both internal and external stakeholders from research conducted over an extended period of time.
Estimating free parameters in 2D inversion: example of gravity inversion in a rifted basement
Authors: Silva João B.C. , Santos Darcicléa F. , Monteiro Daniele P. 
Published: October 2019

ABSTRACTWe advance a principle directed to assigning numerical values to free parameters usually present in inversion methods. It may be formulated as: ‘Optimum estimates of free parameters in an inversion procedure must lead, in tests using synthetic data, to solutions whose geometrical expression reflects the main qualitative or semiquantitative geological characteristic of the study area.’ To this end, the interpreter should (i) specify a typical anomalous source geometry which incorporates the most relevant geological information for the study area, (ii) compute the corresponding gravity anomaly and (iii) invert the anomaly for the source geometry finding the numerical values of the free parameters that lead to a solution closest to the typical source. Application of the above methodology to synthetic and real data from the basement relief of a rift basin has asserted its efficacy.
Consent, Legitimation, and Dysphoria
Authors: West Robin 
Published: October 2019

AbstractIdeals of consent and consensuality are rapidly displacing ideals of legality as the demarcation of lawful from unlawful, legitimate from illegitimate, and good from bad. This is a particularly pronounced trend in the areas of sexual and reproductive rights and ethics. Consensual sex has almost completely displaced marital sex as the demarcation of not only criminal from laudatory sex but also good from bad sex. Likewise, the consensuality of a pregnancy is increasingly the demarcation of a celebrated rather than mourned pregnancy, rather than its marital province. This development is justly celebrated as a breakthrough in women's rights and equality, but it carries costs. This essay develops some of the limits and perils of an over‐reliance on consent and consensuality as the primary criterion of the morality of sex and reproduction. Consent is not always a trustworthy guide to wellbeing, for both general reasons, and reasons specific to sexual and reproductive life.
A Missing Citizen? Issue Based Citizenship in City‐Regional Planning
Authors: Häkli Jouni , Kallio Kirsi Pauliina , Ruokolainen Olli 
Published: October 2019

AbstractCity regions are significant sites of economic development, policymaking, and everyday living. Yet in many countries they are weakly institutionalized and therefore lack established democratic practices. This article is based on a study exploring citizen participation in city‐regional planning in Finland, where traditional participatory means have largely failed to invite and involve citizens. The analysis approaches city regions relationally, as evolving processes with a changing spatial shape and scope. Through the notion of lived citizenship, including the dimensions of status, practices and acts, the article reveals how the dominant ideas of citizenship in city‐regional planning hide from view elements that are significant for citizen participation. Whereas people's rights to participation can largely be fulfilled on a territorial basis in municipalities and states through legal membership in political communities, in the context of weakly institutionalized city‐regional planning such status‐based forms of participation are typically not available. This vagueness has created an image of a missing city‐regional citizenry, which the article sets out to challenge and rework through the notion of issue‐based participation as lived citizenship.