bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal analysis of complete blood count parameters in advanced‐stage lung cancer patients
Authors: Rojko Livia , Megyesfalvi Zsolt , Czibula Eszter , Reiniger Lilla , Teglasi Vanda , Szegedi Zsolt , Szallasi Zoltan , Dome Balazs , Moldvay Judit 
Published: September 2020

BackgroundMetastatic lung cancer is a debilitating disease, but with the advances in immunotherapy, therapeutic options have vastly increased. Numerous complete blood count parameters (CBC) have been described as easily accessible biomarkers that might predict response to immunotherapy. However, to date, no comprehensive study has been performed on the longitudinal changes of these parameters during cancer progression.MethodsThe clinicopathological variables and CBC parameters of 986 advanced stage lung cancer patients were retrospectively analyzed. Blood tests were performed as part of the routine checkup and the results were recorded at the time of the diagnosis of the primary tumor, the diagnosis of brain or bone metastases, and also during the last available follow‐up.ResultsIn the experimental subcohort, 352 and 466 patients were diagnosed with brain and bone metastases, respectively. The control group consisted of 168 patients without clinically detectable or other distant organ metastases. In our longitudinal analyses, we found significantly decreasing absolute lymphocyte count (ALC: P < 0.001), and significantly increasing absolute neutrophil count (ANC: P < 0.001) levels in all patient subgroups, irrespective of histopathological type and metastatic site. Interestingly, patients with brain metastases had significantly descending‐ascending platelet count (PLT) trendlines (P < 0.001), while the bone metastatic subgroup exhibited significantly ascending‐descending trendlines (P = 0.043).ConclusionsSignificantly decreasing ALC, significantly increasing ANC and fluctuating PLT levels may be found in brain and bone metastatic lung cancer patients during disease progression. Our findings might contribute to improve personalized healthcare in this devastating malignancy.Key pointsSignificant findings of the study
Significantly decreasing ALC, and significantly increasing ANC levels can be found in advanced‐stage lung cancer patients during disease progression
Patients with brain metastases have descending‐ascending PLT trendlines, while patients with bone metastases exhibit ascending‐descending trendlines during disease progression
What this study adds
The descending values for ALC, and the ascending mean values for PLT and ANC, might be suggestive of poor response to second‐ or third‐line immunotherapy in advanced‐stage lung cancer patients.
The current study might help to improve patient selection and treatment strategies for brain and/or bone metastatic lung cancer patients.
Serum anti‐LRPAP1 is a common biomarker for digestive organ cancers and atherosclerotic diseases
Authors: Sumazaki Makoto , Shimada Hideaki , Ito Masaaki , Shiratori Fumiaki , Kobayashi Eiichi , Yoshida Yoichi , Adachi Akihiko , Matsutani Tomoo , Iwadate Yasuo , Mine Seiichiro , Machida Toshio , Kamitsukasa Ikuo , Mori Masahiro , Sugimoto Kazuo , Uzawa Akiyuki , Kuwabara Satoshi , Kobayashi Yoshio , Ohno Mikiko , Nishi Eiichiro , Maezawa Yoshiro , Takemoto Minoru , Yokote Koutaro , Takizawa Hirotaka , Kashiwado Koichi , Shin Hideo , Kishimoto Takashi , Matsushita Kazuyuki , Kobayashi Sohei , Nakamura Rika , Shinmen Natsuko , Kuroda Hideyuki , Zhang Xiao‐Meng , Wang Hao , Goto Ken‐ichiro , Hiwasa Takaki 
Published: September 2020

AbstractSome cancers are related to atherosclerotic diseases; therefore, these two types of disease may share some antibody biomarkers in common. To investigate this, a first screening of sera was performed from patients with esophageal squamous cell carcinoma (ESCC) or acute ischemic stroke (AIS) for serological identification of antigens using recombinant cDNA expression cloning (SEREX). The amplified luminescent proximity homogeneous assay‐linked immunosorbent assay (AlphaLISA) method, which incorporates glutathione donor beads and anti‐human IgG acceptor beads, was used to evaluate serum antibody levels. SEREX screening identified low‐density lipoprotein receptor–related protein–associated protein 1 (LRPAP1) as a target antigen of serum IgG antibodies in the sera of patients with ESCC or AIS. Antigens, including recombinant glutathione S‐transferase–fused LRPAP1 protein, were prepared to examine serum antibody levels. AlphaLISA revealed significantly higher antibody levels against the LRPAP1 protein in patients with solid cancers such as ESCC and colorectal carcinoma and some atherosclerosis‐related diseases such as AIS and diabetes mellitus compared with healthy donors. Correlation analysis revealed that the elevated serum antibody levels against LRPAP1 were associated with smoking, a well‐known risk factor for both cancer and atherosclerosis. Serum LRPAP1 antibody is therefore a common marker for the early diagnosis of some cancers and atherosclerotic diseases and may reflect diseases caused by habitual smoking.
Flexing Gender Perception: Brain Potentials Reveal the Cognitive Permeability of Grammatical Information
Authors: Sato Sayaka , Casaponsa Aina , Athanasopoulos Panos 
Published: September 2020

AbstractA growing body of recent research suggests that verbal categories, particularly labels, impact categorization and perception. These findings are commonly interpreted as demonstrating the involvement of language on cognition; however, whether these assumptions hold true for grammatical structures has yet to be investigated. In the present study, we investigated the extent to which linguistic information, namely, grammatical gender categories, structures cognition to subsequently influence categorical judgments and perception. In a nonverbal categorization task, French–English bilinguals and monolingual English speakers made gender‐associated judgments about a set of image pairs while event‐related potentials were recorded. The image sets were composed of an object paired with either a female or male face, wherein the object was manipulated for their conceptual gender relatedness and grammatical gender congruency to the sex of the following target face. The results showed that grammatical gender modulated the N1 and P2/VPP, as well as the N300 exclusively for the French–English bilinguals, indicating the inclusion of language in the mechanisms associated with attentional bias and categorization. In contrast, conceptual gender information impacted the monolingual English speakers in the later N300 time window given the absence of a comparable grammatical feature. Such effects of grammatical categories in the early perceptual stream have not been found before, and further provide grounds to suggest that language shapes perception.
The efficacy and safety of therapeutic lung lavage for exogenous lipoid pneumonia: A systematic review
Authors: Shang Lianhan , Gu Xiaoying , Du Sisi , Wang Yimin , Cao Bin , Wang Chen ,   for CAP‐China Network
Published: September 2020

AbstractIntroduction and objectivesExogenous lipoid pneumonia (ELP) is a lung inflammatory disease with low prevalence and has the feature of external lipid substances presented in the alveoli. Therapeutic lung lavage (segmental bronchoalveolar lavage and whole lung lavage) has been gradually recognized as an important therapy for the disease. There was no comprehensive summary on its efficacy and safety.MethodsWe searched PubMed, Embase, Cochrane Library, CNKI, Wanfang Database, clinicaltrials.gov, and the references of included studies. After study selection, data extraction and quality assessment, we performed a qualitative description of current data.ResultsWe included 90 ELP patients from 25 case reports and 8 case series studies. Eighty‐four (93.3%) patients received segmental bronchoalveolar lavage and six (6.7%) patients received whole lung lavage. Eighty‐seven (96.7%) patients got clinical improvement after lavages, while three (3.3%) patients had no improvement and eventually died. The follow‐up status was reported in 29 patients, of whom 24 patients remained well without any use of drugs and 4 patients remained well with some periods of corticosteroids. One patient endured recurrence. The radiological change was reported in 72 patients, of whom 41 (56.9%) patients had full resolution until the last follow‐up. Two studies reported acute pulmonary edema and transient hypoxemia during lavages.ConclusionsTherapeutic lung lavage might be an effective and safe therapy with long‐term benefits for ELP. Current studies were all case reports and case series with relatively high risk of bias. Prospective controlled studies are needed to explore the actual efficacy, safety, individualized indications, and optimized treatment procedures of therapeutic lung lavage for ELP.
Estimating North Atlantic right whale (Eubalaena glacialis) location uncertainty following visual or acoustic detection to inform dynamic management
Authors: Johnson Hansen D. , Baumgartner Mark F. , Taggart Christopher T. 
Published: September 2020

AbstractThe United States and Canada employ dynamic management strategies to improve conservation outcomes for the endangered North Atlantic right whale (Eubalaena glacialis). These strategies rely on near real‐time knowledge of whale distribution generated from visual surveys and opportunistic sightings. Near real‐time passive acoustic monitoring (PAM) systems have been operational for many years but acoustic detections of right whales have yet to be incorporated in dynamic management because of concerns over uncertainty in the location of acoustically detected whales. This rationale does not consider whale movement or its contribution to location uncertainty following either visual or acoustic detection. The goal of this study was to estimate uncertainties in right whale location following acoustic and visual detection and identify the timescale at which the uncertainties become similar owing to post‐detection whale movement. We simulated whale movement using an autocorrelated random walk model parameterized to approximate three common right whale behavioral states (traveling, feeding, and socializing). We then used a Monte Carlo approach to estimate whale location over a 96‐hr period given the initial uncertainty from the acoustic and visual detection methods and the evolving uncertainties arising from whale movement. The results demonstrated that for both detection methods the uncertainty in whale location increases rapidly following the initial detection and can vary by an order of magnitude after 96 hr depending on the behavioral state of the whale. The uncertainties in whale location became equivalent between visual and acoustic detections within 24–48 hr depending on whale behavior and acoustic detection range parameterization. These results imply that using both visual and acoustic detections provides enhanced information for the dynamic management of this visually and acoustically cryptic and highly mobile species.
Clarifying the effect of refractive errors and stereopsis on traumatic dental injuries in childhood
Authors: Kiziltan Eliacik Basak , Eliacik Mustafa 
Published: September 2020

AbstractBackground/AimVisual acuity and stereopsis both play an important role in developing posture and balance in children. The aim of this study was to investigate whether children with traumatic dental injuries (TDI) have abnormal stereopsis, due to a reduction in visual acuity, compared to children with good dental health.Material and MethodsA total of 140 participants (75 with traumatic dental injuries resulting from falls and crashes, and 65 age‐matched controls without dental trauma) were enrolled in this prospective, cross‐sectional study. The participants underwent complete dental and ophthalmologic examinations. After the ophthalmologic examination, the stereo acuities were assessed by a Titmus stereo test at 40 cm.ResultsTitmus test scores were significantly worse in the TDI group (mean score 252.46 ± 629.12 seconds of arc) compared to the control group (mean score 56 ± 27.39 seconds of arc) (P < .05). The percentage of subjects with abnormal Titmus test scores was higher in the TDI group (28%) than in the control group (3.1%). The mean anisometropia value was 3.03 ± 2.37 D and 0.55 ± 0.41 D in the TDI group and the control group, respectively (P < .001). The severity of anisometropia correlated with the degree of stereopsis (r = .83, P < .01).ConclusionsThe presence of abnormal stereopsis may lead to postural instability which can lead to traumatic dental injuries. The prevalence of abnormal stereopsis in children with TDI was higher than in children with good binocular vision and stereopsis.
Variability of radiation use efficiency in mixed pastures under varying resource availability, defoliation and time scale
Authors: Grigera Gonzalo , Oesterheld Martín 
Published: September 2020

AbstractForage productivity is the product between incident radiation, the fraction of radiation absorbed by the canopy (fAPAR) and radiation use efficiency (RUE). The extent to which forage productivity may be estimated through remote sensing depends on the relative effects of stress and defoliation on fAPAR and RUE. In a mixed pasture, we determined the relative impact of resource availability and defoliation on forage productivity, fAPAR and RUE, and we evaluated the impact of time scale on fAPAR and RUE under stress conditions. We conducted a one‐year experiment in a temperate‐mixed pasture subjected to different resource availability treatments and defoliation management. We measured RUE and fAPAR with different temporal windows. RUE was less responsive than fAPAR to changes in resource availability and defoliation intensity. However, RUE slightly decreased under water stress and increased under severe defoliation. Additionally, RUE variability during regrowth and among treatments depended on the temporal scale of observation: RUE was more variable for 12‐day periods than 45‐ or 90‐day periods. Our results reinforce the value of fAPAR as an explanatory variable of the variations in forage productivity due to changes in resource availability and management. In addition, the temporal scale of observation affects RUE variability. Thus, most variations of forage productivity may be captured by monitoring systems based on remote sensing of fAPAR provided that the time scale is coarse enough. However, the contrasting response of RUE and fAPAR to defoliation indicates a potential weakness of such a system when situations with contrasting defoliation regime are compared.
The societal burden of haemophilia A. III – The potential impact of emicizumab on costs of haemophilia A in Australia
Authors: Brown Laurie J. , La Hai A. , Li Jinjing , Brunner Matthias , Snoke Martin , Kerr Annette M. 
Published: September 2020

AbstractIntroductionEmicizumab is a humanized monoclonal modified IgG4 antibody with bispecific antibody structure bridging Factor IXa and Factor X. Emicizumab has demonstrated efficacy and safety in adults, adolescents and paediatrics with HA, with or without inhibitors to Factor VIII (FVIII). There is currently no evidence that reports on the potential impact of the introduction of emicizumab on the societal costs of haemophilia A (HA). The purpose of this study was to explore the cost impact associated with the introduction of emicizumab on the current societal costs of people with HA (PwHA) in Australia.MethodsWe conducted an analysis of the impact of emicizumab on societal costs, based on changes in the direct and indirect costs incurred by PwHA. Potential impacts of emicizumab on outcomes in PwHA were modelled based on HAVEN 1, HAVEN 2 and HAVEN 3 studies. We assumed that eligible PwHA commenced use of emicizumab on 1 January 2018. The impact of emicizumab on costs of HA in Australia males was then estimated for the 12‐month period to 31 December 2018.ResultsOverall, uptake of emicizumab in its first year of use reduces annual costs associated with moderate/severe HA by AUD$69.197M (62.3%). This reflects 64.2% reduction in the cost of FVIII blood products and 92% reduction in cost of bypassing agents.ConclusionThe cost of emicizumab is likely to offset some or all of the projected reductions in treatment costs. However, we also found 30.7% reduction in non‐treatment direct costs (AUD$3.771M) and 19.1% reduction in indirect costs (AUD$2.732M).
Application of gas chromatography–mass spectrometry (GC‐MS)‐based metabolomics for the study of fermented cereal and legume foods: A review
Authors: Adebo Oluwafemi Ayodeji , Oyeyinka Samson Adeoye , Adebiyi Janet Adeyinka , Feng Xi , Wilkin Jonathan D. , Kewuyemi Yusuf Olamide , Abrahams Adrian Mark , Tugizimana Fidele 
Published: September 2020

AbstractA new era of cutting‐edge technologies and advancements in analytical platforms and omics sciences is disruptively bringing a paradigm shift in fundamental and translational research. Metabolomics is one of the omics strategies that yields big data and has gained popularity in a wide spectrum of applications. Among various analytical platforms used in metabolomics, gas chromatography–mass spectrometry (GC‐MS) allows the measurement of thermally stable (volatiles and semi‐volatiles) metabolites, with an advantage of spectral reproducibility. Cereal‐ and legume‐based fermented foods are part of the food culture in various countries throughout the world. Thus, this review provides an overview of recent applications of GC‐MS‐based metabolomics in the food fermentation field, specifically cereal‐ and legume‐based fermented foods. This emerging use of metabolomics in food fermentation studies illustrates the potentials of this omics science to elucidate metabolome landscapes of fermented foods. Such insights would advance our predictive understanding of fermentation processes and molecular descriptions of resultant food products, a necessary step for improvements and sustainability in food industry. Furthermore, the review echoes the current need of collaborative efforts in the scientific community (in this field) to harness and maximise the potentials of metabolomics in food fermentation studies.
Gluten‐free cookies added with fibre and bioactive compounds from blackcurrant residue
Authors: Gagneten Maite , Archaina Diego A. , Salas M. Paula , Leiva Graciela E. , Salvatori Daniela M. , Schebor Carolina 
Published: September 2020

AbstractA blackcurrant by‐product of juice production was dehydrated and added to a gluten‐free chocolate cookies formulation as a source of dietary fibre and antioxidants. The blackcurrant ingredient showed high bioactive compounds content: total phenolics (TPC) = 37.5 ± 0.9 mg GAE per g d.b., total monomeric anthocyanins = 18.0 ± 0.4 mg cyanidin‐3‐glucoside per g d.b., antioxidant activity (AA) = 22.1 ± 0.3 mg GAE per g d.b. and total dietary fibre (TDF) = 32.3 ± 0.4% d.b. The cookie formulation was added with 3.75% blackcurrant powder without causing severe organoleptic changes. The cookies presented 62% and 70% increase of TPC and AA, respectively. The in vitro digestion showed that a relevant level of AA could reach the large intestine. Also, the TDF increased 2.5 times, reaching a final content that would enable the use of the claim 'source of dietary fibre' in the labelling according to the Codex Alimentarius. The obtained cookies showed a high level of acceptance among coeliac and non‐coeliac consumers in the sensory analysis.
By‐products of the classification of chickpea as an alternative in the production of hummus
Authors: Losano Richard Pedro , Steffolani M. Eugenia , Allende María José , Carreras Julia , León Alberto Edel 
Published: September 2020

AbstractChickpea (Cicer arietinum L.) is a valuable source of protein, polyunsaturated fatty acids, polyphenols, dietary fibre, vitamins and complex carbohydrates, such as oligosaccharides with prebiotic activity. This study evaluates the use of by‐products derived from the classification of chickpea as functional ingredients in food production. The chemical content and thermal properties of by‐products (discard and split) were determined and compared to whole grains for export. Split grains had a higher protein content, lower water hydration capacity (WHC) and lower fibre. The content of oligosaccharides was lower in discard grains. For further studies, hummus was prepared with three samples, and texture and sensory analyses were performed. The results of texture and sensory analyses show no significant differences between discard and whole grains. Chemical contents of by‐products show advantages for the food industry. Discard grains can be used to prepare hummus with the same technology and sensory quality as whole grains.
Association between erectile dysfunction and fibromyalgia in male patients: A Taiwanese nationwide population‐based cohort study
Authors: Ou Shi‐Chen , Lin Mei‐Chen , Lin Hung‐Jen , Huang Chi‐Ping , Huang Sheng‐Teng 
Published: September 2020

ObjectivesTo investigate the association between erectile dysfunction and fibromyalgia, and to clarify related comorbidities and treatment modalities.MethodsThis retrospective cohort study was carried out using 1 million records in the National Health Insurance Research Database. From 2001 to 2012, a total of 53 678 male patients newly diagnosed with fibromyalgia were recruited as the fibromyalgia cohort, and the same number of the non‐fibromyalgia cohort was enrolled and matched with propensity score with age, income, comorbidities, and prescribed medications. All records were followed up until the end of 2013. The Cox proportional hazards model was carried out to assess the risk of erectile dysfunction among fibromyalgia patients.ResultsThe incidence rates of erectile dysfunction were 36.86 and 21.15 (per 10 000 person‐years) in the fibromyalgia and non‐fibromyalgia cohorts, respectively, and a significantly increased risk of erectile dysfunction in fibromyalgia patients was noted (adjusted hazard ratio 1.69, 95% confidence interval 1.55–1.85, P < 0.001). The Cox proportional hazards regression analysis showed increased risk of erectile dysfunction in the fibromyalgia cohort regardless of treatment prescriptions of tramadol, antidepressants, gabapentin and non‐steroidal anti‐inflammatory drugs.ConclusionsFibromyalgia was found to be an independent risk factor for the incidence of erectile dysfunction.
Digital enforcement: Rethinking the pursuit of a digitally‐enabled society
Authors: Díaz Andrade Antonio , Techatassanasoontorn Angsana A. 
Published: September 2020

AbstractIn this article, we aim to sensitise the information systems community about the dispossession of choice that the extended reliance on Internet technology creates for individuals. The overemphasis of digital inclusion as a solution to the digital divide problem frames Internet use as desirable in a progressive society but labels non‐use as problematic or a deficiency that needs to be remedied. This situation, we argue, creates a new modality of inequality that we termdigital enforcement, defined as the process of dispossession that reduces choices for individuals who prefer to minimise their reliance on the Internet if given the opportunity or those who want to live their lives offline altogether. We present digital enforcement as an ethical problem and draw on the concepts of governmentality and technologies of power to explain how practices around Internet use in society result in digital enforcement. We conclude with a hopeful perspective to call for an ethical agenda to develop desirable futures.