bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Literature Review of Brain Neurostimulation Therapies for the Treatment of Pain
Authors: Deer Timothy R , Falowski Steven , Arle Jeff E , Vesper Jan , Pilitsis Julie , Slavin Konstantin V , Hancu Maria , Grider Jay S , Mogilner Alon Y 
Published: February 2020

AbstractObjectiveTo conduct a systematic literature review of brain neurostimulation for pain.DesignGrade the evidence for deep brain neurostimulation (DBS).MethodsAn international, interdisciplinary work group conducted a literature search for brain stimulation. Abstracts were reviewed to select studies for grading. Randomized controlled trials (RCTs) meeting inclusion/exclusion criteria were graded by two independent reviewers. General inclusion criteria were prospective trials (RCTs and observational) that were not part of a larger or previously reported group. Excluded studies were retrospective or existed only as abstracts. Studies were graded using the modified Interventional Pain Management Techniques–Quality Appraisal of Reliability and Risk of Bias Assessment, the Cochrane Collaborations Risk of Bias assessment, and the United States Preventative Services Task Force level-of-evidence criteria.ResultsTwo high-quality RCTs and three observational trials supported DBS, resulting in Level II (moderate) evidence.ConclusionModerate evidence supports DBS to treat chronic pain. Additional Level I RCTs are needed to further the strength of the evidence in this important area of medicine, but the current evidence suggests that DBS should be considered as an option in treating complex pain cases.
On Tangency in Equisingular Families of Curves and Surfaces
Authors: Giles Flores Arturo , Silva O N , Snoussi J 
Published: February 2020

AbstractWe study the behavior of limits of tangents in topologically equivalent spaces. In the context of families of generically reduced curves, we introduce the $s$-invariant of a curve and we show that in a Whitney equisingular family with the property that the $s$-invariant is constant along the parameter space, the number of tangents of each curve of the family is constant. In the context of families of isolated surface singularities, we show through examples that Whitney equisingularity is not sufficient to ensure that the tangent cones of the family are homeomorphic. We explain how the existence of exceptional tangents is preserved by Whitney equisingularity but their number can change.
The Effect of Cash Injections: Evidence from the 1980s Farm Debt Crisis
Authors: Bergman Nittai K , Iyer Rajkamal , Thakor Richard T 
Published: February 2020

AbstractWhat is the effect of cash injections during financial crises? Exploiting county-level variation arising from random weather shocks during the 1980s Farm Debt Crisis, we analyze and measure the effect of local weather-driven cash flow shocks on the real and financial sectors. We show that such cash flow shocks significantly affect a host of economic outcomes, including land values, loan delinquency rates, the probability of bank failure, employment, and wages. Estimates of the effect of local cash flow shocks on county income levels during the financial crisis yield a multiplier of 1.63.
Happiness in Hard Times: Does Religion Buffer the Negative Effect of Unemployment on Happiness?
Authors: Hastings Orestes P , Roeser Kassandra K 
Published: February 2020

AbstractTwo well-known findings are that the religious are happier than the non-religious, and people are less happy when they lose their job. We investigate a link between these by asking whether religion buffers against the negative effect of unemployment on happiness. Although theorized or implicitly assumed in many studies, empirical demonstrations of a causal, moderating effect of religion have been infrequent and often not strong methodologically. We conduct individual-level fixed effects models to test for the buffering effect in the US context using recent panel data from the 2006–2014 General Social Surveys. Religious service attendance, belief in life after death, and trying to carry one’s religious beliefs over into other dealings in life all substantially buffered the effect of unemployment on happiness. Praying daily, believing God exists, identifying as a religious person, and having a religious affiliation did not. We discuss these results in the context of prior work and existing theory. To further support a causal interpretation of these findings, we also conduct a secondary analysis showing that unemployment does not appear to increase or decrease religiousness. This paper makes an important sociological contribution to the growing field of happiness research and to our understanding of how religion matters to people during hard times.
Race, Racism, and the Cool Pose: Exploring Black and White Male Masculinity
Authors: Unnever James D , Chouhy Cecilia 
Published: February 2020

Abstract
Scholars argue that racial oppression uniquely causes Black males to construct a definition of their masculinity—the “Cool Pose”—that is different from White male masculinity. In this paper, using a nationally representative survey conducted in 2018, we examined whether young Black males were more likely than White male youths to feel greater pressure to conform to the Cool Pose. We analyzed six measures of the Cool Pose. We found no evidence that young Black males were more likely than White male youths to feel greater pressure to use violence if provoked. However, we found that young Black males were more likely than White male youths to feel greater pressure to be physically and emotionally strong, play sports, and to dominate or control others. We conclude that research needs to move beyond idiosyncratic accounts of Black males’ cultural adaptations in order to explicate the developmental processes that affect how Black males living in a systemically racist society express their masculinity.
Leishmanial selenoproteins and the host immune system: towards new therapeutic strategies?
Authors: Rashidi Sajad , Kalantar Kurosh , Nguewa Paul , Hatam Gholamreza 
Published: February 2020

AbstractOptimum levels of selenoproteins are essential for starting and managing the host immune responses against pathogens. According to the expression of selenoproteins in Leishmania parasites, and since high levels of selenoproteins lead to adverse effects on immune cells and their functions, Leishmania parasites might then express selenoproteins such as selenomethionine in their structure and/or secretions able to challenge the host immune system. Finally, this adaptation may lead to evasion of the parasite from the host immune system. The expression of selenoproteins in Leishmania parasites might then induce the development of infection. We therefore suggest these molecules as new therapeutic candidates for the treatment of leishmaniasis.
A review of applications of visual inspection technology based on image processing in the railway industry
Authors: Liu Scarlett , Wang Quandong , Luo Yiping 
Published: February 2020

Abstract
In order to ensure the safety of railway transportation, it is necessary to regularly check for faults and defects in the railway system. Visual inspection technology is conducive to improving the low efficiency, poor economy and inaccurate detection results of traditional detection methods. This paper introduces the research and contribution of various scholars in the field of visual inspection, summarizes the application and development of visual inspection technology in the railway industry, and finally forecasts the future research direction of visual inspection technology.
Circulating tumor DNA in neoadjuvant treated breast cancer reflects response and survival
Authors: Magbanua Mark Jesus M. , Brown-Swigart Lamorna , Wu Hsin-Ta , Hirst Gillian L. , Yau Christina , Wolf Denise M. , Tin Antony , Salari Raheleh , Shchegrova Svetlana , Pawar Hemant , Delson Amy L. , DeMichele Angela , Liu Minetta C. , Chien A. Jo , Asare Smita , Lin Cheng-Ho J. , Billings Paul , Aleshin Alexey , Sethi Himanshu , Louie Maggie , Zimmermann Bernhard , Esserman Laura J. , van ’t Veer Laura J. 
Published: February 2020

AbstractPathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) is strongly associated with favorable outcome. We examined the utility of serial circulating tumor DNA (ctDNA) testing for predicting pCR and risk of metastatic recurrence in 84 high-risk early breast cancer patients treated in the neoadjuvant I-SPY 2 TRIAL. Cell-free DNA (cfDNA) was isolated from 291 plasma samples collected at pretreatment (T0), 3 weeks after initiation of paclitaxel (T1), between paclitaxel and anthracycline regimens (T2), or prior to surgery (T3). A personalized ctDNA test was designed to detect 16 patient-specific mutations (from whole exome sequencing of pretreatment tumor) in cfDNA by ultra-deep sequencing. At T0, 61 of 84 (73%) patients were ctDNA-positive, which decreased over time (T1-35%; T2-14%; T3-9%). Patients who remained ctDNA-positive at T1 were significantly more likely to have residual disease after NAC (83% non-pCR) compared to those who cleared ctDNA (52% non-pCR; OR 4.33, P=0.012). After NAC, all patients who achieved pCR were ctDNA-negative (n=17, 100%). For those who did not achieve pCR (n=43), ctDNA-positive patients (14%) had significantly increased risk of metastatic recurrence (HR 10.4; 95% CI, 2.3–46.6); interestingly, patients who did not achieve pCR but were ctDNA-negative (86%) had excellent outcome, similar to those who achieved pCR (HR 1.4; 95% CI, 0.15–13.5). Lack of ctDNA clearance was a significant predictor of poor response and metastatic recurrence, while clearance was associated with improved survival regardless of pCR status. Personalized monitoring of ctDNA during NAC may aid in real-time assessment of treatment response and help fine-tune pCR as a surrogate endpoint of survival.
Network-based Drug Repurposing for Human Coronavirus
Authors: Zhou Yadi , Hou Yuan , Shen Jiayu , Huang Yin , Martin William , Cheng Feixiong 
Published: February 2020

AbstractHuman Coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle east respiratory syndrome coronavirus (MERS-CoV), and 2019 novel coronavirus (2019-nCoV), lead global epidemics with high morbidity and mortality. However, there are currently no effective drugs targeting 2019-nCoV. Drug repurposing, represented as an effective drug discovery strategy from existing drugs, could shorten the time and reduce the cost compared to de novo drug discovery. In this study, we present an integrative, antiviral drug repurposing methodology implementing a systems pharmacology-based network medicine platform, quantifying the interplay between the HCoV-host interactome and drug targets in the human protein-protein interaction network. Phylogenetic analyses of 15 HCoV whole genomes reveal that 2019-nCoV has the highest nucleotide sequence identity with SARS-CoV (79.7%) among the six other known pathogenic HCoVs. Specifically, the envelope and nucleocapsid proteins of 2019-nCoV are two evolutionarily conserved regions, having the sequence identities of 96% and 89.6%, respectively, compared to SARS-CoV. Using network proximity analyses of drug targets and known HCoV-host interactions in the human protein-protein interactome, we computationally identified 135 putative repurposable drugs for the potential prevention and treatment of HCoVs. In addition, we prioritized 16 potential anti-HCoV repurposable drugs (including melatonin, mercaptopurine, and sirolimus) that were further validated by enrichment analyses of drug-gene signatures and HCoV-induced transcriptomics data in human cell lines. Finally, we showcased three potential drug combinations (including sirolimus plus dactinomycin, mercaptopurine plus melatonin, and toremifene plus emodin) captured by the ‘Complementary Exposure’ pattern: the targets of the drugs both hit the HCoV-host subnetwork, but target separate neighborhoods in the human protein-protein interactome network. In summary, this study offers powerful network-based methodologies for rapid identification of candidate repurposable drugs and potential drug combinations toward future clinical trials for HCoVs.
Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection
Authors: Chai Xiaoqiang , Hu Longfei , Zhang Yan , Han Weiyu , Lu Zhou , Ke Aiwu , Zhou Jian , Shi Guoming , Fang Nan , Fan Jia , Cai Jiabin , Fan Jue , Lan Fei 
Published: February 2020

AbstractA newly identified coronavirus, 2019-nCoV, has been posing significant threats to public health since December 2019. ACE2, the host cell receptor for severe acute respiratory syndrome coronavirus (SARS), has recently been demonstrated in mediating 2019-nCoV infection. Interestingly, besides the respiratory system, substantial proportion of SARS and 2019-nCoV patients showed signs of various degrees of liver damage, the mechanism and implication of which have not yet been determined. Here, we performed an unbiased evaluation of cell type specific expression of ACE2 in healthy liver tissues using single cell RNA-seq data of two independent cohorts, and identified specific expression in cholangiocytes. The results indicated that virus might directly bind to ACE2 positive cholangiocytes but not necessarily hepatocytes. This finding suggested the liver abnormalities of SARS and 2019-nCoV patients may not be due to hepatocyte damage, but cholangiocyte dysfunction and other causes such as drug induced and systemic inflammatory response induced liver injury. Our findings indicate that special care of liver dysfunction should be installed in treating 2019-nCoV patients during the hospitalization and shortly after cure.
Habitat selection drives dietary specialisation inSorex minutus
Authors: Ware Roselyn L. , Booker Annie L. , Allaby Francesca R. , Allaby Robin G. 
Published: February 2020

AbstractTo meet their demand for food, Eurasian pygmy shrews (Sorex minutus) require large territories, normally in fields, woodlands, and meadows. Their high metabolism and food requirement often leads to high mortality during winter. However, evidence of shrews in the roof voids of residential buildings has recently been observed, contrary to ecological expectations. Here, five faecal samples collected from different locations were studied by metagenomic analysis to gain information about the shrew’s diets and environments. Two of the samples were collected from novel indoor locations, while the other three were from outdoors in ‘traditional’ habitats. Distinct differences were observed between the diets of the two populations, suggesting a commensal niche expansion has occurred inS. minutus.We found thatS. minutusexploit man-made spaces for foraging, potentially at the cost of a greater parasite burden.
Area per player in small-sided games to replicate the external load and estimated physiological match demands in elite soccer players
Authors: Riboli Andrea , Coratella Giuseppe , Rampichini Susanna , Cé Emiliano , Esposito Fabio 
Published: February 2020

AbstractThe current study determined the area-per-player during small- or large-sided games with or without goalkeeper that replicates the relative (m·min−1) total distance, high-intensity running distance, sprint distance and metabolic power covered during official matches. Time-motion analysis was performed on twenty-five élite soccer-players during 26 home-matches. A total of 2565 individual samples for SSGs using different pitch sizes and different number of players were collected and classified as SSGs with (SSG-G) or without goalkeeper (SSG-P). A between-position comparison was also performed. The area-per-player needed to replicate the official match demands waslargelygreater in SSG-GvsSSG-P for total distance [187±53 vs 115±35 m2, effect size (ES): 1.60 95%CI 0.94/2.21], high-intensity running distance [262±72 vs 166±39 m2, ES: 1.66(0.99/2.27)] and metabolic power [177±42 vs 94±40, ES: 1.99(1.31/2.67)], but similar for sprint distance [(316±75 vs 295±99 m2, ES: 0.24(−0.32/0.79)] with direction of larger area-per-player for sprint distance > high-intensity running > total distance ≅ metabolic power for both SSG-G and SSG-P. In SSG-G, forwards required greater area-per-player than central-defenders [ES: 2.96(1.07/4.35)], wide-midfielders [ES: 2.45(0.64/3.78)] and wide-defenders [ES: 3.45(1.13/4.99)]. Central-midfielders required greater area-per-player than central-defenders [ES: 1.69(0.20/2.90)] and wide-midfielders [ES: 1.35(−0.13/2.57)]. In SSG-P, central defenders need smaller area-per-player (ES: −6.01/−0.92) to overall replicate the match demands compared to all other positions. The current results highlight that soccer players need a specific area-per-player during the small-side games with or without goalkeeper to replicate the overall match demands, especially to perform high-intensity running or sprint distance. Additionally, central defenders, central midfielders and forwards need to be trained with tailored area-per-player or specific rules/additional exercises.
Polar opposites; bacterioplankton susceptibility and mycoplankton resistance to ocean acidification
Authors: de Scally Storme Zaviar , Chaffron Samuel , Makhalanyane Thulani Peter 
Published: February 2020

ABSTRACTMicroorganisms form the basis of ocean ecosystems yet the effects of perturbations such as decreasing pH on microbial community structure, interactions and functionality remain compared to multicellular organisms. Using an experimental manipulation of Southern Ocean seawater, we subjected bacterioplankton and mycoplankton to artificial pH decreases, which are predicted to occur in the future. We show that acidification led to substantial increases of bacterioplankton diversity, while in contrast it had no effect on mycoplankton diversity. Our analyses revealed a loss of putative keystone taxa and a decrease in predicted community interactions as a response to lower pH levels. Bacterioplankton shifted from generalist to specialist community members, suggesting a specific stress response to unfavourable conditions. In addition, enzyme activities involved in nitrogen acquisition were lower at reduced pH levels, suggesting altered organic matter cycling in a more acidic ocean. Our findings suggest that bacterioplankton and mycoplankton may respond differentially to future ocean acidification, with potentially negative impacts on community structure and biogeochemical cycling in the Southern Ocean.IMPORTANCEOceans absorb the majority of anthropogenically produced CO2, the consequence of which is ocean acidification, a phenomenon already negatively impacting key marine organisms. Marine microbial communities form the basis of ocean food webs by generating nutrients for higher trophic levels, yet the response of these key microbial drivers to acidification remains unclear. This knowledge deficit is particularly true for understudied marine ecosystems such as the Southern Ocean. Using a mesocosm approach, we found that acidification severely impacts microbial community stability, by altering bacterioplankton community structure, reducing network complexity, and augmenting enzyme activities associated with nitrogen acquisition. This study adds to our understanding of the effects of ocean acidification on microbial communities, particularly within an environment expected to be largely effected by future anthropogenically driven climate change.
Distinguishing Viruses Responsible for Influenza-Like Illness
Authors: Spencer Julie A. , Shutt Deborah P. , Moser Sarah K. , Clegg Hannah , Wearing Helen J. , Mukundan Harshini , Manore Carrie A. 
Published: February 2020

AbstractThe many respiratory viruses that cause influenza-like illness (ILI) are reported and tracked as one entity, defined by the CDC as a group of symptoms that include a fever of 100 degrees Fahrenheit and a cough and/or a sore throat. In the United States alone, ILI impacts 9-49 million people every year. While tracking ILI as a single clinical syndrome is informative in many respects, the underlying viruses differ in their parameters and outbreak properties. Most existing models treat either a single respiratory virus or ILI as a whole. However, there is a need for models capable of comparing several individual ILI viruses. To address this need, here we present a flexible model and simulations of epidemics for influenza, RSV, rhinovirus, seasonal coronavirus, adenovirus, and SARS/MERS, parameterized by a systematic literature review and accompanied by a global sensitivity analysis. We find that for these biological causes of ILI, their parameter values, timing, prevalence, and proportional contributions differ substantially. These results demonstrate that distinguishing the viruses that cause influenza-like illness will be an important aspect of future work on ILI diagnostics, mitigation, modeling, and preparation for future unknown pandemics.
Using predicted imports of 2019-nCoV cases to determine locations that may not be identifying all imported cases
Authors: De Salazar PM , Niehus R , Taylor A , Buckee C , Lipsitch M 
Published: February 2020

AbstractCases from the ongoing outbreak of atypical pneumonia caused by the 2019 novel coronavirus (2019-nCoV) exported from mainland China can lead to self-sustained outbreaks in other populations. Internationally imported cases are currently being reported in several different locations. Early detection of imported cases is critical for containment of the virus. Based on air travel volume estimates from Wuhan to international destinations and using a generalized linear regression model we identify locations which may potentially have undetected internationally imported cases.
Space-time dynamics in monitoring neotropical fish communities using eDNA metabarcoding
Authors: Sales Naiara Guimarães , Wangensteen Owen Simon , Carvalho Daniel Cardoso , Deiner Kristy , Præbel Kim , Coscia Ilaria , McDevitt Allan D. , Mariani Stefano 
Published: February 2020

ABSTRACTThe biodiverse Neotropical ecoregion remains insufficiently assessed, poorly managed, and threatened by unregulated human activities. Novel, rapid and cost-effective DNA-based approaches are valuable to improve understanding of the biological communities and for biomonitoring in remote areas. Here, we evaluate the potential of environmental DNA (eDNA) metabarcoding for assessing the structure and distribution of fish communities by analysing sediments and water from 11 locations along the Jequitinhonha River catchment (Brazil). Each site was sampled twice, before and after a major rain event in a five-week period and fish diversity was estimated using high-through-put sequencing of 12S rRNA amplicons. In total, 252 Molecular Operational Taxonomic Units (MOTUs) and 34 fish species were recovered, including endemic, introduced, and previously unrecorded species for this basin. Spatio-temporal variation of fish assemblages was detected, richness during the first campaign was nearly twice as high as in the second sampling round; though peaks of diversity were primarily associated with only four locations. No correlation between β-diversity and longitudinal distance or presence of dams was detected, but low species richness observed at sites located near dams indicates that these anthropogenic barriers might have an impact on local fish diversity. Unexpectedly high α-diversity levels recorded at the river mouth suggest that these sections should be further evaluated as putative “eDNA reservoirs” for rapid monitoring. By uncovering spatio-temporal changes, unrecorded biodiversity components, and putative anthropogenic impacts on fish assemblages, we further strengthen the potential of eDNA metabarcoding as a biomonitoring tool, especially in regions often neglected or difficult to access.