bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery and Validation of Serum Autoantibodies Against Tumor-Associated Antigens as Biomarkers in Gastric Adenocarcinoma Based on the Focused Protein Arrays
Authors: Yang Qian , Qin Jiejie , Sun Guiying , Qiu Cuipeng , Jiang Di , Ye Hua , Wang Xiao , Dai Liping , Zhu Jicun , Wang Peng , Zhang Jianying 
Published: December 2020

INTRODUCTION:
Previous studies have demonstrated that autoantibodies against tumor-associated antigens (TAAs) in patients with cancer can be used as sensitive immunodiagnostic biomarkers for the detection of cancer. Most of these TAAs are involved in the tumorigenesis pathway. Cancer driver genes with intragenic mutations can promote tumorigenesis. This study aims to identify autoantibodies against TAAs encoded by cancer driver genes in sera as potential immunodiagnostic biomarkers for gastric adenocarcinoma (GAC).

METHODS:
Protein arrays based on cancer driver genes were customized for screening candidate TAAs in 100 GAC sera and 50 normal control (NC) sera. Autoantibodies against candidate TAAs were assessed by enzyme-linked immunosorbent assay in both training group (205 GAC sera and 205 NC sera) and independent validation group (126 GAC sera and 126 NC sera). Moreover, the immunodiagnostic models were respectively established and validated in the training group and validation group.

RESULTS:
A panel with 5 autoantibodies including anti-TP53, anti-COPB1, anti-GNAS, anti–serine/arginine-rich splicing factor 2, and anti-SMARCB1 was selected by the Fisher linear discriminant analysis model with an areas under receiver operating characteristic curve (AUC) of 0.928 (95% confidence interval [CI]: 0.888–0.967) in the training cohort and an AUC of 0.885 (95% CI: 0.852–0.918) in the validation cohort. Besides, the panel with 5 autoantibodies including anti-TP53, anti-COPB1, anti-GNAS, anti-PBRM1, and anti-ACVR1B which were selected by the binary logistic regression model showed an AUC of 0.885 (95% CI: 0.852–0.919) in the training cohort and 0.884 (95% CI: 0.842–0.925) in the validation cohort.

DISCUSSION:
Two panels which were selected in this study could boost the detection of anti-TAA autoantibodies in sera as biomarkers for the detection of GAC.
TEORIA ANTICOLONIAL E CURRÍCULO ESCOLAR BRASILEIRO
Authors: Azevedo José Roberto Nunes de 
Published: December 2020

A reflexão acerca da escola pública à luz das políticas públicas empreendidas pela União, estados e municípios é um ponto necessário para apreendermos as formas pela qual são conduzidas a formação dos alunos na educação básica. Para alcançar o objetivo lançamos mãos de metodologia qualitativa baseada na leitura de documentos institucionais voltados à seara educacional e revisão bibliográfica em torno do assunto proposto e, por outro lado, da experiência e participação no âmbito escolar na última década no Estado de São Paulo e Mato Grosso do Sul. As primeiras pistas da investigação em andamento nos leva a perceber que há um longo caminho a se percorrer no que tange ao alcance de melhores condições de aprendizagem e superação do fracasso escolar tanto no Estado de São Paulo como no Brasil, muito embora haja um quadro bastante desigual quando considera-se os resultados da educação escolar pública.
The spatial distribution of retail outlets in Urumqi: The application of points of interest
Authors: Yannan Zhao , Lu Zhang , Xinhuan Zhang 
Published: December 2020

Abstract
Studies on the distribution of retail outlets are crucial for optimizing urban resource allocation, and their rationalized layout plays an important role in developing urban economies and meeting consumer demand. However, the literature on the subject has been limited by data collection. In the era of big data, there has been an emergence of geo-referenced data that are more accurate and convenient and thus more able to be applied in the retail analysis. This study addresses this lacuna by exploring the spatial distribution of various retail outlets with the application of points of interest. Our study demonstrates that (1) the retail outlets in Urumqi are concentrated in the inner city. The inner-city area has a higher density distribution of retail outlets, and the development of the retail function is more mature. (2) Various categories of retail outlets display dissimilar agglomeration characteristics and hot spots. Specialty stores, clothing and footwear stores, convenience stores, and home-building material markets have lower average nearest-neighbor distances. (3) The retail outlets in the subject area are directionally distributed in the northwest–southeast direction, which is the result of both the topographical condition and government intervention in Urumqi. (4) Various categories of retail outlets tend to agglomerate at different scales. These results are conducive to the exploration of the location rules and layout preferences of retail locations, and they provide a reference for guiding the adjustment and optimization of retail layouts.
História e condição feminina na obra A Carne (1888), de Júlio Ribeiro
Authors: Neto Joachin Azevedo , Da Silva Ediene Gomes 
Published: December 2020

Este artigo analisa o romance A Carne, publicado pela primeira vez em 1888, a partir da inserção dessa narrativa ficcional em uma perspectiva embasada nos estudos de sexualidade e da história das mulheres. Foi realizada uma abordagem comparativa entre A Carne e outros romances naturalistas do mesmo período, com ênfase na crítica social presente nessa literatura. Sobretudo, no tocante as idealizações românticas sobre o matrimônio que eram colocadas como padrões a ser seguidos pelas mulheres. A obra destacada, em termos gerais, causou uma grande polêmica e foi censurada por vários jornalistas e críticos literários que atuaram na imprensa carioca. Problematizamos, portanto, a representação da mulher e a reação de alguns jornalistas ao romance A Carne.
An empirical analysis of terrorism impact on public debt: A dynamic heterogeneous panel approach
Authors: Jaidane-Mazigh Lamia , Khefacha Islem , Chamakh Aymen 
Published: December 2020

The increase in the frequency of terrorist attacks and the availability of data has enhanced the interest of economists in analysing this phenomenon and studying its impact on the economy. Besides the loss of lives, terrorism can seriously strain public finance. Indeed, these events promote the increase of national security expenditures which leads either to the reallocation of public resources with a fall in productive investment or to an increase in the sovereign debt. Furthermore, terrorist attacks affect financial markets and lead risk premium escalation, thus increasing government borrowing cost. This paper tries to examine the causal relationship between terrorism and public debt for 19 developed and developing economies, frequently affected by terrorism attacks, for the period of 2002â€“2017. Due to the presence of cross-sectional dependence in the panel, we employ the Pesaranâ€™s Cross-sectionally augmented Im-Pesaran-Shin test to ascertain unit root properties. The Westerlund cointegration test indicates the presence of a long-run association between terrorism and public debt estimated through the augmented mean group method. We show that an increase in the Global Terrorism Index can impact public debt more in MENA than in Western countries.
Keywords: Terrorism, public debt, cross-section dependence, heterogeneity panel cointegration.
Transición, transformación y latencia : las diferentes vidas del conjunto “Torres Vermelhas” = Transition, transformation and latency: the consecutive lives of the “Torres Vermelhas” complex
Authors: Noormahomed Patricia 
Published: December 2020

Resumen En Maputo (Mozambique) numerosos programas de vivienda colectiva fueron desarrollados durante la segunda mitad del siglo XX siguiendo los principios del Movimiento Moderno y con­stituyéndose como columna vertebral de su actual paisaje urbano. En este contexto, el conjunto Torres Vermelhas destaca como caso paradigmático al quedar su construcción interrumpida por los acontecimientos que motivaron la independencia del país en 1975. Un cambio político que vino acompañado de un complejo proceso de resignificación cultural y funcional. El presente artículo pretende explorar la vida arquitectónica de este conjunto en sus diferentes temporalidades mediante el estudio del potencial de sus innovadores mecanismos de adaptación y transformación. Se busca aquí, participar en la construcción de una historia alternativa al canon eurocéntrico a través de una metodología de proyecto disciplinar que considera los procesos de identidad y de reapropiación social como fundamentales para la comprensión y valoración crítica de este legado como patrimonio cultural.AbstractIn Maputo (Mozambique), a large number of collective housing programs were develo­ped during the second half of the twentieth century following the principles of the Modern Movement. This architectural production represents a significant part of the city’s current backbone where the Torres Vermelhas complex stands out as a paradigmatic case, as its construction was interrupted by the events that led to the country’s independence in 1975. A political change that was accompanied by a complex process of cultural and functional resignification. Within this framework, this article seeks to explore the architectural life of these buil­dings in their different temporalities by studying the potential of their adaptation and trans­formation mechanisms. The aim, thus, is to participate in the construction of an alternative to the Eurocentric canon through a disciplinary project methodology that considers the pro­cesses of identity and social re-appropriation as fundamental to the critical evaluation of this legacy as cultural heritage.
PENSAR DEUS
Authors: Savian Juvenal 
Published: December 2020

VASILIU, Anca. Penser Dieu – Noétique et métaphysique dans l’Antiquité Tardive. Paris: Vrin, 2018, 410p. ISBN 9782711628285.
A pensadora romeno-francesa Anca Vasiliu, pesquisadora do CNRS (Centre National de la Recherche Scientifi que) e do Centro Léon-Robin (centro de pesquisas sobre o pensamento antigo da Université de Paris- -Sorbonne) possui uma obra de altíssima e reconhecida relevância para os estudos do pensamento antigo e tardoantigo, não apenas por seu rigor técnico, filológico e conceitual, mas também pelas inspirações que por vezes se permite receber de temas contemporâneos que lançam luz sobre aspectos inusitados do pensamento antigo e tardoantigo ou mesmo encontram nessas formas de pensamento uma fonte sempre nova que, se não contribui para um esclarecimento total de tais temas, certamente possibilita expandir os horizontes de sua própria inteligibilidade. Tendo sido orientada por Jean-Luc Marion em seu doutorado sobre o conceito de diáfano no pensamento antigo e medieval,1 a pensadora é também historiadora da arte, especializada na arte bizantina e nas tradições culturais dos cristãos do Oriente (...)
A Randomized Clinical Trial on the Effect of Foot Reflexology in the Fourth Stage of Labor on Uterine After Pain
Authors: Sharifi Neda , Bahri Narjes , Talasaz Fateme Hadizade , Azizi Hoda , Nezami Hosein 
Published: December 2020

Abstract
Objective: Uterine after-pains are among the most prevalent complaints after natural vaginal delivery. Non-pharmacological treatment modalities to relieve after-pains are an important care priority. This study aimed to investigate the effect of foot reflexology in the fourth stage of labor on after-pains in multiparous women.Methods: This single-blind randomized clinical trial recruited 80 eligible pregnant women presenting to Allameh Bohlool Hospital in Gonabad and 17-Shahrivar Hospital in Mashhad in 2019. In the first and second hours postpartum, the reflexology group received 10 minutes of general massage and specific reflexology massage on each foot in uterine, pituitary, and solar plexus points. The control group received 10 minutes of general massage, and then rotational massage on a neutral point on the lateral side of the heel. The pain was measured every hour up to 4 hours postpartum using a visual analog scale. The collected data were analyzed in SPSS-16 software at a significance level of P<0.05.Results: The median of after-pain score in the first hour postpartum was not statistically significantly different between the two groups (P=0.05), but it was lower in the reflexology group at the second (P=0.04), third (P<0.001), and fourth hours postpartum (P<0.001). The mean total after-pain score of the four hours postpartum was significantly lower in the reflexology group (P<0.001).Conclusions: The results revealed that foot reflexology in the fourth stage of labor has positive effects on the relief of uterine after-pain. It is therefore recommended that reflexology be used to reduce postpartum uterine after-pain.
Analysis of the Incidence and Risk factors of Postoperative Delirium in Patients with Degenerative Cervical Myelopathy
Authors: Kim Seok Woo , Lee Jeong Hwan , Lee Min Uk , Lee Hyung Min , Lee Seung Hun , Kim Young Eun 
Published: December 2020

Abstract
Delirium is one of the most common postoperative complications in surgical procedures. Postoperative delirium (POD) may affect normal recovery and outcomes after surgery. Degenerative Cervical myelopathy (DCM), a disease that progresses with age, usually associated with neurological symptoms. This study is designed to analyze the incidence and risk factors that cause post-operative delirium in DCM. The incidence and risk factors of delirium were analyzed in 148 patients aged 60 years or older who underwent surgery for DCM. Among the 148 patients who underwent surgery, 78 received laminoplasty, of whom 19 patients (24%) experienced delirium; the other 70 patients underwent ACDF, of whom five patients (7.1%) experienced delirium. The occurrence of POD in the laminoplasty group was 4.18 times higher than that in the ACDF group. Age, and sodium level were found to be significant risk factors for all 148 patients in a multivariate analysis. In the laminoplasty group, age, and high potassium level were meaningful risk factors in multiple regression analysis. Risk factors that affect the POD were not analyzed in ACDF due to the low n(=5). This study shows that the incidence and risk factors for POD can vary depending on the surgical method employed in patients with DCM.
Oil Palm Cultivation Critically Affects Sociality in an Endangered Malaysian Primate
Authors: Holzner Anna , Balasubramaniam Krishna , Ruppert Nadine , Widdig Anja 
Published: December 2020

Abstract
Human-induced habitat alterations globally threaten animal populations, often evoking complex behavioural responses in wildlife. This may be particularly dramatic when negatively affecting social behaviour, which fundamentally determines individual fitness and offspring survival in group-living animals. Here, we provide first evidence for critical behavioural modifications in sociality of Southern pig-tailed macaques visiting Malaysian oil palm plantations in search of food. Specifically, we found significant reductions of positive social interactions, an increase of aggression and shifts in the macaques' social network structure, with the central positions of high-ranking adult females and immatures being passed to low-ranking individuals, likely resulting from socio-ecological risks posed by plantations. Deviations from natural behaviour also affected the smallest but crucial social units within groups, mother-infant pairs, with increased maternal protectiveness at plantations. We suggest that although primates can persist in human-altered habitats, their ability to adapt comes with a trade-off for their natural sociality, potentially hampering infant development and individual survival. Studies like ours remain critical for understanding species’ adaptability to anthropogenic landscapes, which may ultimately contribute to facilitating their coexistence with humans and preserving biodiversity.
Derivation and Validation of Gray-Box Models to Estimate Non-Invasive In-vivo Percentage Glycated Hemoglobin Using Digital Volume Pulse Waveform
Authors: Hossain Shifat , Gupta Shantanu Sen , Kwon Tae-Ho , Kim Ki-Doo 
Published: December 2020

Abstract
Glycated hemoglobin and blood oxygenation are the two most important factors for monitoring a patient’s oxygen levels in the blood and the amount of average blood glucose levels. Digital Volume Pulse acquisition is a convenient method, even for a person with no previous training or experience, can be utilized to estimate the two abovementioned physiological parameters. The physiological basis assumptions are utilized to develop two-finger models for estimating the percent glycated hemoglobin and blood oxygenation levels. The first model consists of a blood vessel only hypothesis, while the second model is based on a whole-finger model system. We validated our two gray-box systems on diabetic and non-diabetic patients and obtained the mean absolute errors for the percent glycated hemoglobin (%HbA1c) and percent oxygen saturation (%SpO2) of 0.375 and 1.676, respectively, for the blood vessel model and 0.271 and 1.395, respectively, for the whole-finger model. The precision analysis indicated that these models resulted in 2.08% and 1.74% mean %CV for %HbA1c and 0.54% and 0.49% mean %CV for %SpO2 in the respective models. Herein, both models exhibit close performances to each other (HbA1c estimation Pearson R values are 0.92 and 0.96, respectively), even though the model assumptions greatly differed between them. Both of the models have a very high potential to be used in real-world scenarios. The whole-finger model performs better in terms of higher precision and accuracy compared to the blood vessel model.
Identification of the Signature Associated with m6A RNA Methylation Regulators and m6A-Related Genes and Construction of the Risk Score for Prognostication in Early-Stage Lung Adenocarcinoma
Authors: Guo Bingzhou , Zhang Hongliang , Wang Jinliang , Wu Rilige , Zhang Junyan , Zhang Qiqin , Xu Lu , Shen Ming , Zhang Zhibo , Gu Fangyan , Zeng Weiliang , yin chengliang 
Published: December 2020

Abstract
Background: N6-methyladenosine (m6A) RNA modification play critical roles in multiple levels including the regulation of degradation, subcellular localization, splicing and local conformation changes of RNA transcripts. In this study, we aim to conduct comprehensive investigation on m6A RNA methylation regulators and m6A-related genes and their association with prognosis in early-stage Lung adenocarcinoma (LUAD). Methods: The relevant datasets which were used to analyze 21 m6A RNA methylation regulators and 887 m6A-related genes in m6Avar were downloaded from Gene Expression Omnibus database (GEO) and The Cancer Genome Atlas (TCGA) databases. Univariate cox regression analysis, random survival forest analysis, Kaplan-Meier anylysis, STRING and multivariate cox analysis were carried out, and a risk prognostic model based on five feature genes was constructed. Respectively, we treated GSE31210 (n=226) as training set, GSE50081 (n=128) and TCGA data (n=461) as test set. Results: By performing univariable cox regression and random survival forest algorithm in the training group, five prognosis-related genes including DENND1A, KBTBD6, KIF4A, BMPER, and YTHDC2 were screened out, which could divide LUAD patients into low-risk group and high-risk group (log rank p <0.001). The predictive efficacy of these genes was confirmed in the test group GSE50081 (log rank p <0.01) and TCGA datasets (log rank p <0.001). Cox analysis showed that this five-gene signature was an independent risk factor in LUAD. Further, genes in the signature were also external validated using online database. YTHDC2 played vital role of readers in m6A methylation. Conclusions: The findings of this study suggested that associated with m6A-related genes and m6A RNA methylation regulators, five-gene signature was reliable prognostic indicator for LUAD patients, indicating a clinical application prospect to serve as a potential therapeutic target.
The Impact of the Pre-operative Neutrophil-lymphocyte Ratio as the Predictive Marker of Post-operative Weight Loss and Improving Diabetes in Sleeve Gastrectomy.
Authors: Kashihara Hideya , Shimada Mitsuo , Yoshikawa Kozo , Higashijima Jun , Tokunaga Takuya , Nishi Masaaki , Takasu Chie , Yoshimoto Toshiaki , Eto Shohei 
Published: December 2020

Abstract
Background: The aim of this study was to investigate the impact of the neutrophil-lymphocyte ratio (NLR) in sleeve gastrectomy (SG).Methods: 15 obese patients were enrolled in this study. They consisted of 5 males and 10 females: mean body weight (BW) 127.5kg; mean body mass index (BMI) 46.7kg/m2. 10 of these were diabetics who underwent a SG. The impact of the pre-operative NLR on the percentage of excess weight loss (%EWL) and remission of diabetes 1 year post-operative were examined.Results: The BMI, %EWL and %TWL at 1 year post-operative were 35.1 kg/m2, 46.3% and 26.2%, respectively. Improvements were also evident in the diabetes at 1 year post-operative: complete remission (CR) (No medication and hemoglobin A1c (HbA1c) HbA1c<6.0%) 40%, PR (HbA1c<6.5) 20%; and (decrease of anti diabetic drug and HbA1c<7.0%) 40%. Comparing pre-operative NLR in %EWL<50% and >50% in one (1) year post-operative, <50% was 2.64 and >50% was 2.03 (p<0.05). The NLR in CR and partial remission (PR) was significantly lower than that in improved (Improve) (2.22 vs 3.27, p<0.05).Conclusions: The pre-operative NLR may be a predictive marker of weight loss and improving diabetes after SG.
Adapting Lot Quality Assurance Sampling to accommodate imperfect tests: application to COVID-19 serosurveillance in Haiti
Authors: Fulcher Isabel , Clisbee Mary , Lambert Wesler , Leandre Fernet Renand , Hedt-Gauthier Bethany 
Published: December 2020

Abstract
Background: Lot Quality Assurance Sampling (LQAS), a tool used for monitoring health indicators in low resource settings resulting in “high” or “low” classifications, assumes that determination of the trait of interest is perfect. This is often not true for diagnostic tests, with imperfect sensitivity and specificity. Here, we develop Lot Quality Assurance Sampling for Imperfect Tests (LQAS-IMP) to address this issue and apply it to a COVID-19 serosurveillance study in Haiti.Results: As part of the standard LQAS procedure, the user specifies allowable classification errors for the system, which is defined by a sample size and decision rule. We show that when an imperfect diagnostic test is used, the classification errors are larger than specified. We derive a modified procedure, LQAS-IMP, that accounts for the sensitivity and specificity of a diagnostic test to yield correct classification errors. We apply our methods to create a sampling scheme at Zanmi Lasante health facilities in Haiti to assess the prior circulation of COVID-19 among healthcare workers (HCWs) using a limited number of antibody tests. Conclusions: The LQAS-IMP procedure accounts for imperfect sensitivity and specificity in system design; if the accuracy of a test is known, the use of LQAS-IMP extends LQAS to applications for indicators that are based on laboratory tests, such as COVID-19 antibodies.