bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of the duration of post-thaw culture with clinical outcome after vitrified-warmed day 3 embryo transfer in 10,464 cycles
Authors: Zhu Haiyan , Xu Wen , Jin Xiaoying , Xue Yamei , Tong Xiaomei , Zhang Songying 
Published: August 2020

Abstract
This study aimed to investigate the effect of the duration of embryo culture on clinical outcome in vitrified-warmed cycles.
This retrospective cohort study enrolled 10,464 infertile patients, with a total of 18,843 vitrified-warmed day 3 embryos from 2012 to 2017 at a single center. The patients were divided into 2 groups: 9470 cycles in the short-term culture group (0.5–8 hours of post-thaw culture) and 994 cycles in the 48 to 72 hours culture group. The independent effect of the following variables on clinical outcomes was determined: duration of post-thaw culture, maternal age, transferred embryos, embryo quality, and endometrial thickness.
We found that the pregnancy rate was positively associated with the post-thaw culture time. Ordinary least square regression analyses showed that the duration of post-thaw culture was positively associated with implantation and live birth rates overall. However, the implantation and live birth rates were not significantly associated with the post-thaw culture time in the short-term culture group. Additionally, maternal age and the number of transferred embryos were independent predictors of the implantation and live birth rates. Moreover, the duration of post-thaw culture did not affect live birth weight.
These results indicated that the pregnancy rate is positively associated with the duration of post-thaw culture. Therefore, under the condition of not affecting work shifts, properly prolonging the duration of post-thaw culture to improve the outcome of frozen-thawed embryo transfer should be considered.
Impact of thyroid ultrasonography combined ultrasound-guided fine-needle aspiration biopsy in detection thyroid microcarcinoma
Authors: Han Zhuan-Ning , Liu Zhe , Wang Jing 
Published: August 2020

Abstract

Background:
This study aims to explore the accuracy of thyroid ultrasonography (TUS) combined ultrasound-guided fine-needle aspiration biopsy (UGFNAB) for detection of thyroid microcarcinoma (TMC).

Methods:
A comprehensive search in PUBMED, EMBASE, Cochrane Library, Web of Science, Scopus, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure from the beginning to the June 1, 2020 without language and publication status limitations. Two authors will independently perform articles identification, data extraction and assessment of study quality. Any disagreements will be resolved by discussion with a third author. We will carry out study quality evaluation using Quality Assessment of Diagnostic Accuracy Studies tool, and will employ statistical analysis using RevMan V.5.3 and Stata V.12.0 softwares.

Results:
We will summarize current evidence to investigate the accuracy of TUS combined UGFNAB in detection of TMC.

Conclusion:
The findings of this study may provide helpful evidence of TUS combined UGFNAB in detection of TMC.

Study registration:
INPLASY202070048.
Acupuncture improves postoperative symptoms of pigmented villonodular synovitis
Authors: Tang Hongzhi , Fan Huaying , Luo Fei , Huang Li , Liao Shichuan , Yu Wenjing , Chen Yunbei , Chen Jiao , Qin Xuefei 
Published: August 2020

Abstract

Background:
Pigmented villonodular synovitis (PVNS) is a benign proliferative disease of synovial joint, synovial sac and tendon sheath. PVNS is usually treated by surgery, but postoperative joint dysfunction and pain will be accompanied, which seriously affects the quality of life. The purpose of this review is to evaluate the effectiveness and safety of this intervention in patients with pain and dysfunction caused by postoperative symptoms of PVNS.

Methods:
We will search the EMBASE, the Cochrane Library, Ovid MEDLINE, PubMed, Web of Science, Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI), Wanfang Database, the Chongqing VIP (VIP), the US National Institute of Health, the NIH clinical registry Clinical Trials, the ICTRP, and the Australian New Zealand Clinical Trials Registry and the Chinese clinical registry, from their inception to 1st July 2020. Randomized controlled trials that include patients with postoperative symptoms of pigmented villonodular synovitis receiving acupuncture therapy versus a control group will be included. The selection of studies, data extraction and risk of bias assessment will be conducted by 2 independent researchers. A third review author resolved disagreements. The dichotomous data will be presented as risk ratios with 95% confidence intervals (CIs) and the continuous data will be presented as weighted mean differences or standardized mean differences with 95% CIs. Evidence quality will be evaluated using the GRADE system.

Results:
The results will be disseminated through a peer-reviewed journal publication.

Conclusions:
This systematic review will provide updated evidence of various types of acupuncture specifically focuses on its effectiveness and safety for patients’ pain and dysfunction caused by post-operation of pigmented villonodular synovitis.

Ethics and dissemination:
Ethical approval is not necessary as this review will not require data from individual patients. The results of this will be published through peer-reviewed journal articles or conference presentations.

Registration:
Open Science Framework (OSF). 2020, July 7. 10.17605/OSF.IO/CZW9P.
Spontaneous spinal epidural hematoma masquerading as atypical abdominal pain in a child
Authors: Cheng Xueliang , Qu Yang , Dong Rongpeng , Yang Lili , Kang Mingyang , Zhao Jianwu 
Published: August 2020

Abstract

Introduction:
There have been few case reports of abdominal pain as a symptom of spontaneous intraspinal hemorrhage. We herein describe a case involving a girl with paraplegia caused by spontaneous epidural hemorrhage in the thoracic spinal canal, characterized by abdominal pain.

Patient concerns:
An 8-year-old girl with sudden abdominal pain and back pain was misdiagnosed as having an abdominal disease until she had the symptom of paralysis.

Diagnoses:
The patient was diagnosed with spontaneous intraspinal hemorrhage masquerading as atypical abdominal pain.

Interventions:
When the patient developed symptoms of lower extremity paralysis, thoracic magnetic resonance imaging was performed and epidural hemorrhage was found in the thoracic spinal canal. Surgical treatment was performed after the diagnosis was confirmed.

Outcomes:
The patient could almost walk normally after 3 months. One year after surgery, the Frankel grade of spinal cord function was grade D. We continued to follow-up this patient.

Conclusion:
The symptoms caused by intraspinal hemorrhage are mainly back pain with or without neurological dysfunction. However, sometimes atypical symptoms, such as abdominal and chest pain, can be identified in clinical settings. Emergency surgery is recommended as the treatment of choice for intraspinal hemorrhage with neurological dysfunction.
Minimally invasive plate osteosynthesis or conventional intramedullary nailing for distal tibial fractures
Authors: Song Xin , Huang Xun , Yakufu Maihemuti , Yan Bin , Feng Chencheng 
Published: August 2020

Abstract

Background:
Currently, both minimally invasive plate osteosynthesis (MIPO) and intramedullary nailing are the two most commonly used methods of treatment in distal tibial fractures, but controversy still exists regarding the clinical effects of 2 techniques. Our purposes were to compare MIPO and intramedullary nailing for distal tibia shaft fractures by assessing functional outcomes and complications.

Methods:
Data were collected retrospectively from the charts of patients treated for distal tibial extra-articular fractures between May 2012 and July 2018. All cases were performed by a single surgeon. Institutional review board approval in the Second Affiliated Hospital of Army Medical University was obtained prior to conducting chart review and analysis. The criteria for inclusion in the study were being aged at least 18 years at the time of diagnosis and having a closed or type I open fracture of the distal third of the tibial diaphysis. The primary outcome compared between the 2 groups was the American Orthopedic Foot and Ankle surgery score. The secondary outcome measures in this trial included Olerud and Molander Ankle Score, radiographic outcomes, and complications. Statistical analysis was performed using SPSS version. P values < .05 were considered statistically significant.

Results:
We hypothesized that MIPO would be associated with better functional outcomes and fewer complications.

Trial registration:
This study protocol was registered in Research Registry (researchregistry5808).
A personalized treatment program in persons with type 2 diabetes is associated with a reduction in liver steatosis
Authors: Björkström Karl , Stål Per , Holmer Magnus , Bengtsson Bonnie , Staaf Annika , Hoffstedt Johan , Hagström Hannes 
Published: August 2020

Background and aims
It is unclear if improving glycemic control in persons with type 2 diabetes (T2D) also has liver-related effects. We aimed to evaluate if a personalized treatment program associates with improvement of liver-related parameters in persons with advanced T2D in a real-life setting.

Methods
Persons with advanced T2D underwent a 4-day personalized treatment program, with the aim of improving glycemic control by dietary advice, instructions on how to achieve optimal glucose control and individualized dosage of medications. Transient elastography was used to estimate liver steatosis and fibrosis. Persons with liver diseases other than non-alcoholic fatty liver disease (NAFLD) were excluded. After 3 months, study participants were offered re-examination.

Results
Ninety-one persons were included. Of these, 75 persons (82%) had controlled attenuation parameter (CAP) measurements of acceptable quality at baseline. Of these, 57 (76%) had NAFLD (defined as >268 dB/m). Twenty-two persons (24%) had elevated liver stiffness (>7.9 kPa), and eight (9%) had liver stiffness above 13.9 kPa, indicating advanced fibrosis. Over a median follow-up of 101 days, mean CAP in persons with NAFLD was reduced by 18.33 dB/m (P = 0.035). In persons with elevated liver stiffness, mean stiffness was reduced by 2.6 kPa (P = 0.047). In linear regression, one-unit improvement in fasting glucose (mg/dl) was associated with a decrease in hepatic steatosis with 0.48 dB/m (adjusted R2 = 0.35, P < 0.01).

Conclusion
The prevalence of NAFLD with advanced fibrosis is high in persons with advanced T2D. Improving glycemic control through a personalized treatment program is associated with a reduction in liver steatosis and stiffness in this cohort.
Presentation and Outcomes of Autoimmune Hepatitis Type 1 and Type 2 in Children
Authors: Roepe Isaiah G. , Vierling John M. , Goss John A. , Miloh Tamir 
Published: August 2020

ABSTRACTObjective:Autoimmune hepatitis (AIH) is designated as type 1 or 2 (AIH‐1/2) on the basis of serum autoantibody (Ab) profiles. In children, AIH may present as acute or chronic liver failure or cirrhotic AIH (ALF/CLF/CAIH) with or without overlap sclerosing cholangitis (SC). The aim of this study was to compare demographics, presentation, and outcomes between groups in children.Methods:A retrospective electronic chart review of children with AIH who met standard diagnostic criteria with histologic confirmation at Texas Children's Hospital was performed, with de novo AIH after liver transplant (LT) excluded. Patients were identified and divided into AIH‐1, AIH‐2, ALF, CAIH, AIH‐SC, and LT and compared using chi‐square analysis, Student t‐test, and Mood median test.Results:Among 91 children with AIH, 72 (79.1%) had AIH‐1, 19 (20.9%) had AIH‐2, 13 (14.3%) had ALF, 25 (27.5%) had CAIH, and 14 (15.4%) had AIH‐SC. Both AIH‐1/2 had female and Hispanic predominance (72.2/89.5%, 40.3/57.9%). AIH‐2 presented at younger mean age in years than AIH‐1 (6.8, 12.1, P < 0.05). Both AIH‐1/2 had low rates of remission after 1 year of IS (25.4, 35.7%) and most recent (30.6, 54.5%) follow‐up. Twenty‐two (24.2) patients received LT: 16 had AIH‐1 (72.7%), 6 had AIH‐2 (27.3%), 9 (40.9%) had ALF, and 13 (59.1%) had CAIH. One‐year patient and graft survivals were 100%.Conclusions:The epidemiology and clinical presentation of AIH‐1 and ‐2 had a few subtle differences. AIH‐1 was associated with more complications after LT. More data are needed to better characterize the 2 as separate disease entities.
Extubation Failure and Major Adverse Events Secondary to Extubation Failure Following Neonatal Cardiac Surgery*
Authors: Miura Shinya , Jardim Peter V. , Butt Warwick , Namachivayam Siva P. 
Published: August 2020

Objectives:
To describe the prevalence and consequences of major adverse events secondary to extubation failure after neonatal cardiac surgery.

Design:
A single-center cohort study.

Setting:
A medical-surgical, 30-bed PICU in Victoria, Australia.

Patients:
One thousand one hundred eighty-eight neonates less than or equal to 28 days old who underwent cardiac surgery from January 2007 to December 2018.

Interventions:
None.

Measurements and Main Results:
Extubation failure was defined as unplanned reintubation within 72 hours after a planned extubation. Major adverse event was defined as one or more of cardiac arrest, emergency chest reopening, extracorporeal membrane oxygenation, or death within 72 hours after extubation. One hundred fifteen of 1,188 (9.7%) neonates had extubation failure. Hospital mortality was 17.4% and 2.0% in neonates with and without extubation failure. Major adverse event occurred in 12 of 115 reintubated neonates (10.4%). major adverse event included cardiac arrest (n = 10), chest reopening (n = 8), extracorporeal membrane oxygenation (n = 5), and death (n = 0). Cardiovascular compromise accounted for major adverse event in eight: ventricular dysfunction (n = 3), pulmonary overcirculation (n = 2), coronary ischemia (n = 2), cardiac tamponade (n = 1). In a multivariable logistic regression, factors associated with major adverse event were high complexity in cardiac surgery (odds ratio 5.9; 95% CI: 1.1–32.2) and airway anomaly (odds ratio 6.0; 95% CI: 1.1–32.6). Hospital morality was 25% and 17% in reintubated neonates with and without major adverse event.

Conclusions:
Around 10% of reintubated neonates suffered major adverse event within 72 hours of extubation. Neonates suffering major adverse event had high mortality. Major adverse event should be monitored and reported in future studies of extubation failure. Along with tracking of extubation failure rates, major adverse event secondary to extubation failure may also serve as a key performance indicator for ICUs and registries.
Effects of Blood Flow Restriction Training on Muscle Strength and Pain in Patients With Knee Injuries
Authors: Li Shuoqi , Shaharudin Shazlin , Abdul Kadir Mohammed Rafiq 
Published: August 2020

Background
Due to the pain caused by knee injuries, low-load resistance training with blood flow restriction (L-BFR) may be a potential adjuvant therapeutic tool in the rehabilitation of knee injuries. This review aimed to analyze the effectiveness of L-BFR training modality in knee rehabilitation.

Design
A meta-analysis was conducted to determine the potential impact of blood flow restriction on patients with knee injuries. PubMed, EBSCO, and Web of Science databases were searched for eligible studies from January 2000 until January 2020. The mean differences of the data were analyzed using Revman 5.3 software with a 95% confidence interval.

Results
Nine studies fulfilled the inclusion criteria. These studies involved 179 patients who received L-BFR, 96 patients who underwent high-load resistance training, and another 94 patients who underwent low-load resistance training. The analysis of pooled data showed that patients in both the L-BFR (standardized mean difference, 0.83 [0.53, 1.14], P < 0.01) and high-load resistance training (standardized mean difference, −0.09 [−0.43, 0.24], P = 0.58) groups experienced an increase in muscle strength after the training. In addition, pain score was significantly reduced in the L-BFR group compared with the other two groups (standardized mean difference, −0.61 [−1.19, −0.03], P = 0.04).

Conclusions
Muscle strength increased after L-BFR and high-load resistance training compared with low-load resistance training. Furthermore, pain score was significantly reduced after L-BFR. Hence, L-BFR is a potential intervention to be applied in rehabilitation of knee injuries.
African American Patient Disparities in COVID-19 Outcomes
Authors: Odonkor Charles A. , Sholas Maurice G. , Verduzco-Gutierrez Monica , Zafonte Ross D. , Silver Julie K. 
Published: August 2020

Abstract
SARS-CoV-2 is a novel and highly contagious coronavirus that has been a major threat to the public’s health. As the pandemic has spread across the United States, it has become abundantly clear that vulnerable populations include not only the elderly and individuals with disabilities but also those who are homeless or incarcerated, Latinx Americans, African Americans, and Native Americans. This report is focused on the experience of Black patients, inclusive of African Americans, and recognizes the higher morbidity and mortality in this population. Physiatrists can provide care for the sequelae faced by survivors and prioritize rehabilitation services. Programs must be administered in a way that is geographically accessible to Black communities and demonstrate cultural competence. Future research should focus on the social determinants of health to better understand at-risk populations and improve outcomes.
Sino-Cutaneous Fistula After Using Medpor Implant in Orbital Blowout Fracture
Authors: Kim Jin Il , Cheon Tae Uk , Kim Tae Koon , Nam Jung Gwon 
Published: August 2020

Abstract
In surgical repair of orbital fracture, implant materials play an important role in restoring the functional and anatomic structure of the orbit. Alloplastic implant materials are widely used for this surgery, but they have the risk of complications such as infections, pain, and extrusion. Because they are artificial implants, infection can occur more than autologous implants and is the most challenging problem to manage. Sino-cutaneous fistula is a rare complication of chronic sinusitis and it can be caused by this implant materials. The authors report a case of formation of sino-cutaneous fistula after using Medpor (Stryker Co, MI) implant in orbital blowout fracture repair.
Epidermoid and Dermoid Cysts of the Head and Neck
Authors: Pupić-Bakrač Jure , Pupić-Bakrač Ana , Bačić Ivan , Kolega Marija Škara , Skitarelić Neven 
Published: August 2020

Abstract
Epidermoid and dermoid cysts (ECs and DCs) are congenital anomalies occurring in areas of embryonic fusion. Their incidence in the head and neck region is low and ranges from 1.6% to 7%. The aim of this study is to report on the clinical characteristics, treatment, and outcome of 22 patients from a single-institution experience. A retrospective analysis of patients treated for ECs and DCs of the head and neck over a 12-year period was performed. The present study included 22 patients (male/female ratio 1:1). The mean age of presentation was 11.68 years. The lesions were distributed in the orbital regions in 7 (31.82%) patients, auricular regions in 6 (27.27%), neck regions in 5 (22.73%), floor of the mouth in 3 (13.64%), and nose in 1 (4.55%). Complete surgical excision was performed as a definitive treatment method in 21 patients (95.45%). The mean size of the excised lesions was 21.36 mm at the widest length (range: 10–70 mm). On the basis of histopathological examinations, 15 (71.43%) lesions were classified as ECs and 6 (28.57%) as DCs. Post-operative complications were noted in 3 (14.29%) patients––2 (9.52%) with recurrences and 1 (4.76%) with hypertrophic scarring. All of these patients were successfully cured after a second surgery. The ECs and DCs of the head and neck present an interesting diagnostic and therapeutic challenge. Successful management depends on a thorough knowledge of their clinical and radiological features.
Hereditary transthyretin amyloidosis: current treatment
Authors: Adams David , Slama Michel 
Published: August 2020

Purpose of review
Hereditary transthyretin amyloidosis (ATTRv) is a rare autosomal dominant, life-threatening disease. Until recently only early stages of ATTRv-PN (polyneuropathy) had access to disease-modifying therapy (DMT), whereas there was no specific treatment for ATTRv-CM (cardiomyopathy). This review updates our knowledge about results of three phase 3 clinical trials, expert's consensus for early diagnosis and emerging biomarkers.

Recent findings
Two phase 3 studies using RNAi and antisense oligonucleotides (ASO) were successful. Primary endpoints were progression of neuropathic score mNIS +7 and quality of Life (QOL) in a population of ATTRv-PN at different levels of severity. They knock downed circulating amyloidogenic mutant and wild-type TTR. Safety concerned ASO with a risk of thrombocytopenia. RNAi showed possible reversibility of the disease. Phase 3 ATTRACT trial-tested tafamidis versus placebo in patients with ATTRv-CM and ATTRwt-CM and showed a significant reduction of all-cause mortality and rates of cardiovascular-related hospitalizations. All three drugs obtained marketing authorization by European Medicines Agency (EMA) and Food and drug administration (FDA). Early diagnosis criteria for ATTRv-PN and ATTRv-CM are available. Ongoing clinical trials for ATTRv are presented. New biomarkers are plasma neurofilament light chain, intraepidermal nerve fiber density.

Summary
The majority of patients with ATTRv may have now access to a DMT. Criteria for early diagnosis are available.
COVID-19 in rheumatic diseases: A random cross-sectional telephonic survey
Authors: Goswami Rudra Prosad , Kumar Uma , Kanjilal Maumita , Ray Debaditya , Vij Pallavi , Mittal Dheeraj K , Meena Laxman , Nagar Sandeep , Bhadu Danveer 
Published: August 2020

ABSTRACTObjectiveTo describe the incidence, clinical course, and predictive factors of coronavirus 2019 (COVID-19) infection in a cohort of rheumatological patients residing in New Delhi (National Capital Region), India.MethodsWe performed a cross-sectional, random telephonic survey from 20th April to 20th July 2020 on patients with rheumatic diseases. Patients were interviewed with a predesigned questionnaire. The incidence of COVID-19 in the general population was obtained from open access government data repository. Report of reverse transcriptase polymerase chain reaction report was taken as confirmatory of COVID-19 infection.ResultsAmong the 900 contacted patients 840 responded (713 with rheumatoid arthritis (RA), 100 with systemic lupus erythematosus (SLE), 20 with spondylarthritis (SpA) and 7 with others; mean age 45 ±13 years, mean duration 11.3 ± 6.3 years; 86% female). Among them 29 reported flu-like symptoms and four RA patients had confirmed COVID-19 infection. All of them were hospitalized with uneventful recovery. Rheumatological drugs were discontinued during the infectious episode. Disease modifying agents and biologics were equally received by those with or without COVID-19. The incidence of COVID-19 was similar to general Delhi population (0.476% vs 0.519% respectively, p=0.86). Two patients had relapse of rheumatic disease after recovery. After recovery from COVID-19 or Flu-like illness, eight patients (27.6%, 95% confidence interval 14.7-45.7) reported disease flare.ConclusionPatients with rheumatic diseases in India have similar incidence of COVID-19 infection compared to the community. Relapse of underlying rheumatic disease after recovery is not uncommon and continuation of glucocorticoid through the infection should be considered.