bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concise, Scalable and Enantioselective Total Synthesis of Prostaglandins
Authors: Zhang Fuhao , Zeng Jingwen , Gao Mohan , Wang Linzhou , Chen Gen-Qiang , Lu Yixin , Zhang Xumu 
Published: November 2020

Abstract
Prostaglandins are among the most significant natural isolates owing to their broad range of bioactivities and unique structures. However, the current synthesis of prostaglandins still suffers from low yields and lengthy steps. Here, We reported a practicability-oriented synthetic strategy for the enantioselective and divergent synthesis of PGs. In this approach, the multiply substituted five-membered rings in prostaglandins were constructed via the key Zhang enyne cycloisomerization with excellent selectivity (> 20:1 dr, 98% ee). The crucial chiral center on the scaffold of prostaglandins was installed using the asymmetric hydrogenation method (up to 98% yield and 98% ee). From our versatile common intermediates, a series of PGs and related drugs could be produced in two steps, and fluprostenol could be prepared on a 20-gram scale.
Compact wideband-printed antenna for sub-6 GHz fifth-generation applications
Authors: Kapoor Ankush , Mishra Ranjan , Kumar Pradeep 
Published: November 2020

Abstract
The design of a compact wideband partial slotted ground rectangular-printed antenna is presented. The design approach utilizing the slotted partial ground plane is much more flexible for improving the antenna performance. A detailed design guideline to estimate the antenna dimensions is given, which is based on mathematical and parametric analysis. The effects of variation of length of the ground and slot position in the ground plane are investigated. The simulation has been performed by using HFSS V20 simulator. The designed antenna is meant for being operated in the C band of super-high-frequency (SHF) spectrum and in the n77 band (3.3-4.2 GHz) and n78 band (3.3-3.8 GHz) of frequency range 1 (FR1) in sub-6 GHz 5G-frequency bands. The designed antenna is showing a wide bandwidth (700 MHz) with a low-reflection coefficient of −31.15 dB. The wide bandwidth and compact size of the antenna makes it suitable for use in sub-6 GHz 5G compact wireless communication systems. The measured results of the antenna prototype are firmly authenticated with simulation estimations.
Withdrawal Notice: Inflammatory Bowel Disease in migrant populations - a narrative review
Authors: Estevinho Maria Manuela , Lopes Diogo José M. , Souto Miguel Torre , Magro Fernando 
Published: November 2020

The article has been withdrawn from the journal “Current Drug Targets” due to the English language issues.

Bentham Science apologizes to its readers for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

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Synthesis of Novel Aryl (4-Aryl-1H-Pyrrol-3-yl) (Thiophen-2-yl) Methanone Derivatives: Molecular Modelling, In Silico ADMET, Anti-Inflammatory and Anti-Ulcer Activities
Authors: Pasha Arif , Mondal Sumanta , Panigrahi Naresh 
Published: November 2020

Background::
Due to the presence of both five-membered heterocyclics like pyrrole and
thiophene in one molecule considerable attention was made for their enormous pharmacological activities
out of which include anti-inflammatory and anti-ulcer activities.

Objective:
Chalcones with toluenesulfonylmethyl isocyanide (TosMIC) undergo synthesis to form
some new aryl (4-aryl-1H-pyrrol-3-yl) (thiophen-2-yl) methanone derivatives. Molecular docking
of synthesized compounds with protein receptors of anti-inflammatory COX-1(3N8Y), COX-2
(1PXX) along with anti-ulcer H+/K+ATPase enzyme (2XZB) followed with drug-likeness, and in
silico ADMET properties.

Materials and Methods:
The multicomponent reaction was carried out by the intermediate formation
of α, β-unsaturated ketone from carbonyl compounds which on sequential addition undergoes
[3+2] cycloaddition reaction in same medium affords aryl (4-aryl-1H-pyrrol-3-yl) (thiophen-2-yl)
methanone derivatives by addition of TosMIC in basic medium had resulted in series of compounds
PY1 to PY12. All the new synthesized compounds were screened for their in-vitro anti-inflammatory
activity by bovine serum albumin method followe with COX assay, and in-vivo by using
carrageenan-induced rat paw edema method of the selected compounds PY1, PY5 and PY12
which is also screened for anti-ulcer activity by pylorus ligation method, respectively. Molecular
docking was performed using autodock tools, drug-likeness by OSIRIS property explorer and admetSAR
properties.

Results and Discussion:
From the synthesized compounds of aryl (4-aryl-1H-pyrrol-3-yl) (thiophen-
2-yl) methanone derivatives PY5 showed decent in-vitro and in-vivo anti-inflammatory along
selectivity index of 6.2 for COX-1 with IC50(μM) value of 9.54 over diclofenac with 8.74 and
PY1 showed decent in-vivo anti-ulcer activities along with drug-likeness and in silico ADMET predictions
revealed that all the synthesized compounds have minimal toxic effects with good absorption
as well as solubility characteristics. The selected compounds may serve as potential lead compounds
for developing new anti-inflammatory and anti-ulcer drugs.

Conclusion:
From the newly synthesized molecules PY5 was found to be effective for anti-inflammatory
and PY1 was found to be effective for anti-ulcer activities further derivitization and designed
of modification to achieve more compounds with potent anti-inflammatory and anti-ulcer activities.
Effects of Dexamethasone on Post-dural Puncture Headache in Patients Undergoing Orthopedic Surgery
Authors: Barkhori Hadis , Arefi Farhad , Hushmandi Kiavash , Daneshi Salman , Salehi Jafar , Barkhori Hamideh , Rafee Hamid , Raei Mehdi , Karimi Leila 
Published: November 2020

Background:
The effect of Dexamethasone on Post-Dural Puncture Headache (PDPH) after spinal anesthesia has not been well elucidated. The aim of the current study was to evaluate the effect of prophylactic intravenous dexamethasone on the incidence and severity of PDPH in patients undergoing orthopedic surgery.

Methods:
This randomized, double-blind, placebo-controlled trial was carried out in patients undergoing orthopedic surgery. The subjects were randomly divided into a placebo (n=140) and a dexamethasone (n=140) group. During the surgery, the control group participants were injected 2cc of distilled water, and the dexamethasone group participants were injected 2cc (8mg) of dexamethasone as an infusion in the veins. The incidences of PDPH on the first, third and seventh postoperative days were studied. Data were analyzed using SPSS version 22.

Results:
A total of 280 patients with a mean age of 32.7 ± 11.0 years were studied. The incidence of PDPH on the first day of post-operative period was lower in the dexamethasone group than the control group (21 vs. 34, P<0.05). This difference was disappeared on days 3 and 7. Nausea or vomiting occurred less in the dexamethasone group (9 vs. 26, P<0.05). However, no statistically significant association was found between study groups and the incidence of back pain (P>0.05).

Conclusion:
Although the frequency of PDPH was less in patients receiving dexamethasone, the incidence increased days after the operation and reached the level of the placebo group. We do not recommend prophylactic intravenous dexamethasone for the prevention of PDPH.
Pilot Randomized Clinical Trial Study: Comparative Study of 10% Lidocaine Hydrochloride Solution with Lidocaine Prilocaine Emulsion Prior to Local Anesthetic Injection
Authors: Sargolzaei Naser , Rajabi Omid , Aleyasin Yasaman , Ebrahimi Kamran 
Published: November 2020

Background:
The pain caused by the injection of local anesthetic has been reported as one of the main complaints of dental patients. Topical anesthetics are widely used drugs in dentistry, mainly to control pain associated with the needle penetration in the administration of local anesthesia.

Objective:
The present study aimed to evaluate (5%,7.5% and 10%) concentrations of lidocaine/prilocaine agent, compared to the common 10% lidocaine hydrochloride spray in the oral cavity.

Materials and Methods:
This was a split-mouth double-blind, randomized clinical trial pilot study. We randomized 15 patients, ages 35 to 64 years, with American Society of Anesthesiologists I and II with severe chronic periodontitis who were referred to the dental clinic for surgery, to receive 4 topical anesthetics (5%, 7.5%, and 10%) lidocaine prilocaine emulsion and 10% lidocaine hydrochloride topical anesthetic agent before local infiltration. Primary outcomes were assessing drug safety and pain level that measured by assessment of visual analog scale (VAS) scores of pain during LA injection in the first premolar and second molar in each maxillary quadrant in 15 patients corresponding to the posterior superior alveolar nerve (PSA) and secondary outcome was the relationship between age and gender regarding pain perception, and a total of 60 regions were analyzed.

Results:
Results revealed that there was no statistically significant difference between lidocaine hydrochloride and (5%,7.5% and 10%) lidocaine prilocaine in terms of pain reduction when the 4 different compounds were compared. According to Spearman's rank correlation coefficient and Friedman test, the age and gender of the patients had an insignificant correlation with the anesthetic effects of the four studied solutions.

Conclusion:
Based on these results, age and gender have insignificant effects on the pain scores and it can be said that the four solutions do not have significant differences regarding their anesthetic effects; also, we did not find any adverse reactions by using 7.5% and 10% lidocaine/prilocaine agent.
Relações entre a América Latina e o Oriente Médio.
Authors: Kosheri Ahmed Sadek El 
Published: November 2020

Tratarei das relações entre a América Latina (distinauindo-se o papel do Brasil) e o Oriente Médio, a África, a Ásia e, de modo geral, as outras partes do Terceiro Mundo. Essas relações podem ser classificadas em três estágios já históricos.
AS DIMENSÕES DA OFERTA... - A construção de barragens e o meio ambiente
Authors: MELLO JOÂO ALBERTO BANDEIRA DE 
Published: November 2020

A energia hidrelétrica, além de ser uma fonte renovável, é, entre as demais fontes energéticas, uma das mais baratas. O Brasil, carente de outras formas de energia, possuía, em fins de 1984, um potencial hidrelétrico inventariado da ordem de 213.400 MW, dos quais 16,6% já explorados, 11,7% em projeto ou construção e 71,7% ainda a serem desenvolvidos. É óbvio que, em face das circunstâncias, não se pode, nem se deve, desprezar tamanho potencial. A implantação de qualquer projeto de vulto, seja barragem, rodovia, ferrovia, indústria, irrigação, mineração, ou mesmo urbanização, evidentemente afeta o 'meio ambiente. Na construção de barragens podem advir problemas ambientais especiais. Para solucioná-los, todavia, já existem alguns métodos de comprovada eficiência.
A CAPACITAÇÃO ECONÔMICO-FINANCEIRA... Alternativas de recuperação econômico financeira do Setor Elétrico
Authors: Holandia Jayme Buarque de 
Published: November 2020

Ao contrário da maioria dos países do mundo, o Brasil não deverá enfrentar problemas sérios, do ponto de vista energético, para fornecer eletricidade ao longo das próximas duas décadas. Sob esse aspecto, o problema será decidir entre diversas formas de energia primária disponíveis no país, quais as mais convenientes e em que proporções deverão ser utilizadas. Os problemas do setor elétrico, hoje e anos à frente, situam-se, sobretudo, no plano econômico-financeiro, como conseqüência do alto nível de endividamento em que ele se encontra atualmente. Este endividamento, dada a proporção Que alcançou, torna-se um indicadorsíntese das dificuldadesque transcendem ao aspecto exclusivamente financeiro.
É preciso repensar o Estado e suas relações com a sociedade
Authors: Carvalho Maria do Socorro M. V. de 
Published: November 2020

A Reforma Administrativa recoloca mais uma vez em discussão o problema da inovação e mudança na administração pública, que tanto tem preocupado aqueles que, de uma forma ou de outra, ocupam-se das questões pertinentes ao desempenho do aparato governamental. A idéia de Reforma Administrativa tem aparecido como estratégia através da qual se busca inovar na administração pública, objetivando torná-la um instrumento ágil para a implementação das políticas de Governo. Discutir Reforma Administrativa significa discutir o próprio papel do Estado e do aparato de que se utiliza para garantir a prestação dos serviços demandados pela sociedade. Como a administração pública assume traços do Estado que integra, temos primeiro que repensar o Estado Brasileiro e suas relações com a Sociedade.
O papel do DAS na Administração Pública
Authors: Araújo Antônio Telles de , Neto Franscisco das Chagas de Carvalho , Araújo Raimundo José Cunha 
Published: November 2020

O papel do D.A.S. — Direção e Assessoramento Superior -, na Administração Pública, é um tema que deve ser discutido neste momento em que se está repensando a administração brasileira, quando se tenta implantar uma Reforma Administrativa no País. A sua discussão deverá ser centrada em dois pontos: O papel do DAS no Processo de Integração Organizacional e Interorganizacional. E As habilidades que devem ser desenvolvidas por um ocupante do Grupo DAS. Essas são as questões básicas. Envolvem, de modo geral, toda a problemática da função de assessoramento e direção superior na administração pública, onde o gerente tem de enfrentar problemas de toda ordem, para cumprir a sua missão num emaranhado da burocracia que prende a terra (à organização), lhe prende os braços nos movimentos inúteis da disfunção burocrática e lhe embotam o cérebro pelas rotinas existentes e pelas que tem de seguir e fazer seguir, rigorosamente conforme o figurino. Mas, antes de tudo, o DAS é um gerente da coisa pública (e este é um momento que exige reflexão para uma mudança radical na postura administrativa, se quisermos interagir com o ambiente; se quisermos fazer com que a organização onde trabalhamos acompanhe o ritmo do ambiente que a cerca e que está a exigir cada vez mais uma definição, um novo caminho a percorrer.
Repartir com Coerência Desafio do Legislador
Authors: Lima Egídio Ferreira 
Published: November 2020

“Eu serei breve. E devo dizer inicialmente que é um privilégio viver neste país agora. Estamos numa fase fascinante. Tobias Barreto, já vai tanto tempo, dizia que esse país, esta nação, não teve a oportunidade de constituir, de elaborar o seu estado. O estado brasileiro, até hoje foi elaborado artificialmente por alguns poucos. Creio que é chegada a hora de elaborar o estado a partir da vontade da sociedade.
Care Me Too, a Mobile App for Engaging Chinese Immigrant Caregivers in Self-Care: Qualitative Usability Study
Authors: Liu Mandong , Jiang Tongge , Yu Kexin , Wu Shinyi , Jordan-Marsh Maryalice , Chi Iris 
Published: November 2020

Background
Caregiving and self-care are challenging for Chinese immigrants in the United States due to limited accessible support and resources. Few interventions exist to assist Chinese immigrant caregivers in better performing self-care. To address this gap in the literature, our team developed the Care Me Too app to engage Chinese immigrant caregivers in self-care and conducted a user experience test to assess its usability and acceptability.

Objective
This paper aims to report the results of the app’s usability and acceptability testing with Chinese immigrant caregivers and to solicit participants’ feedback of the app design and functions.

Methods
A total of 22 Mandarin-speaking Chinese caregivers participated in the study, which consisted of 2 parts: the in-lab testing and the 1-week at-home testing. In-depth face-to-face interviews and follow-up phone interviews were used to assess user experience of the app’s usability and acceptability and to solicit feedback for app design and functions. Directed content analysis was used to analyze the qualitative data.

Results
Among the 22 participants, the average age was 60.5 (SD 8.1) years, ranging from 46 to 80 years; 17 (77%) participants were women and 14 (64%) had an associate degree or higher. Participants reported uniformly positive ratings of the usability and acceptability of the app and provided detailed suggestions for app improvement. We generated guidelines for mobile health (mHealth) app designs targeting immigrant caregivers, including weighing flexibility versus majority preferences, increasing text sizes, using colors effectively, providing engaging and playful visual designs and functions, simplifying navigation, simplifying the log-in process, improving access to and the content on the help document, designing functions to cater to the population’s context, and ensuring offline access.

Conclusions
The main contribution of this study is the improved understanding of Chinese caregivers’ user experiences with a language-appropriate mHealth app for a population that lacks accessible caregiving and self-care resources and support. It is recommended that future researchers and app designers consider the proposed guidelines when developing mHealth apps for their population to enhance user experience and harness mHealth’s value.
FROM LETTER TO PHANTASM. SOME REMARKS ON DELEUZE AND PSYCHOANALYSIS IN LOGIC OF SENSE
Authors: MARTA Claudia 
Published: November 2020

From Letter to Phantasm. Some Remarks on Deleuze and Psychoanalysis in Logic of Sense. Our aim is to show how the two heterogeneous series of letter and phantasm make possible, through their convergence understood as the event of sense, a double passage. First, in the order of the Symbolic, the passage of the signifier into the signified. Second, the passage of the whole Symbolic order out of the desiring body. It will be shown that this amounts to a re-conceptualization of causality as sense – event.
Between medicine and rhetoric: therapeutic arguments in Roman Stoicism
Authors: Łapiński Krzysztof 
Published: November 2020

In this paper, I intend to focus on some rhetorical strategies of argumentation which play
crucial role in the therapeutic discourse of Roman Stoicism, namely in Musonius Rufus, Epictetus, Seneca, and Marcus Aurelius. Reference is made to Chaim Perelman’s view of ancient
rhetoric as an art of inventing arguments. Moreover, it is pointed out that in rhetorical education (cf. Cicero, Ad Herennium, Quintilian, etc.) as well as in therapeutic discourse the concept
of “exercise” and constant practice play a crucial role.
The liberation doctrine in Brahmasiddhi of Maṇḍanamiśra
Authors: Sajdek Paweł 
Published: November 2020

The issue of liberation is a recurrent theme in all schools of Indian classical thought. In case of
advaita-vedānta it is deeply rooted in ontology. The problem of ontological status of the world
was the bone of contention for two competing non‑dualist schools of vedānta — vivaraṇa and
bhāmatī. Maṇḍana’s Brahmasiddhi can be regarded as an important source of inspiration for
the latter. The present paper is an analysis of Maṇḍana’s statements pertaining to the issue of
mukti (or mokṣa) in contrast with those of Śankara, the exponent of advaita commonly (though
erroneously) considered the creator and the most prominent representative of the school.
Uwagi o manipulowaniu znaczeniami słów
Authors: Polanowska-Sygulska Beata 
Published: November 2020

On manipulating the meaning of words: the strategy of distorting the meaning of concepts
in order to redirect people’s attitudes has been put in practice by ideologists and politicians
for years. the paper focuses on the refections of selected thinkers and men of letters on this
phenomenon. intellectual contributions of isaiah Berlin, Friedrich a. Hayek, leszek Kołakowski and charles l. stevenson on the one hand, and the considerations of george orwell,
aldous Huxley, ayn Rand, sławomir mrożek and małgorzata musierowicz on the other hand
are analysed. some recent incarnations of the tactics of perverting the meaning of words in
recent political discourse in poland are critically examined. special attention is given to the
manipulating the meaning of “paedophilia” in the context of the nationwide discussion on
child sexual abuse in the catholic church. it is concluded that the dishonourable practice of
verbal misrepresentation used under communism is at work again, this time in even more
sophisticated form.
Joga dla Polki i Polaka. Rzut oka na recepcję indyjskiej duchowości w Polsce
Authors: Jakubczak Marzenna 
Published: November 2020

Yoga for Poles: a glance at the reception of Indian spirituality in Poland: The article starts
with a review of data on the religious afliations and involvement of contemporary Poles, with
special focus on religious traditions originating in India. Then, outlined briefy is the Polish
reception of the Hindu and Buddhist religio-philosophical ideas, regarding the period between
the mid-nineteenth century, through the 1990s and on to the present day. Both the oriental
religions and psychophysical exercises associated with yoga have various connotations for Poles,
who mostly identif themselves as Christians. Along with the gradually growing popularity of
modern postural yoga, one can observe increasing fears and prejudices developing, ones which
are usually based on ignorance or confusion. In the following part of the article the term “yoga”
is elucidated. The author also discusses the origin and the signifcance of yoga as a phenomenon within the context of Hindu culture. Finally, she considers the question as to whether
yoga, as it has been adopted in Polish society, should be rather associated with physical culture
and a method of relaxation or with a religious movement and a spiritual path. In conclusion,
the author addresses the issue of the alleged incompatibility and discrepancy between the non-
-western ideas implied by yoga and the Roman Catholic worldview predominating in Poland.
Estratégias de controle do medo e ansiedade em pacientes odontopediátricos: revisão de literatura
Authors: Torres Maria Eduarda Brandão Balbino , Souza Karina Livia Barros , Cruz Victor Santos Andrade 
Published: November 2020

Objetivo: Verificar os fatores relacionados à ansiedade infantil e o atendimento odontológico e as estratégias adotadas para seu controle por meio de análises bibliográficas. Métodos: Foi realizado uma revisão de literatura, com abordagens informativas, do qual o processo de formulação baseou-se por intermédio de pesquisas em artigos científicos, em bases de dados, possuindo como seus respectivos descritores: Ansiedade ao Tratamento Odontológico, Odontopediatria, Reabilitação Bucal. Resultados: A princípio foi analisado o desencadeamento da ansiedade associada ao medo da criança em ir ao Cirurgião Dentista (CD), desse modo, podendo prejudicar a interrelação entre o profissional e o paciente. O CD necessita dialogar com os responsáveis sobre técnicas de manejo comportamental que são usadas nos procedimentos odontopediátricos, técnicas essas que proporcionam o tratamento a criança com confiança e convicção no trabalho do profissional. Considerações finais: No assistencialismo o entendimento da ansiedade infantil é fundamental para manejar corretamente a consulta e reduzir à sensação de medo no paciente, assim sendo, o estudo mostra estratégias de manejo comportamental pediátrico e sua importância, modificando o atendimento clínico odontopediátrico para menos inquietante e mais eficaz.