bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary lymphoma of the trigeminal nerve presenting as infra‐orbital paraesthesia: A case report and literature review
Authors: Tocaciu Shreya , Dickinson Michael , Goh Christine , Zhao Yi , Kranz Sevastjan , Wiesenfeld David 
Published: November 2020

ABSTRACTBackgroundPrimary lymphoma of the trigeminal nerve is very rare, with only 10 cases reported in the literature. It may present as unexplained paraesthesia of the trigeminal nerve, usually affecting all three divisions of the nerve. To date, a collation of the known cases of primary trigeminal nerve lymphoma is lacking. This study presents a literature review on trigeminal nerve lymphoma, and presents a case to illustrate diagnosis and management.MethodsThe case report of primary trigeminal lymphoma is presented, with long‐term follow‐up. A review of the known cases of primary trigeminal lymphoma is conducted, demonstrating the current understanding on diagnosis and management of these rare lesions.ResultsA 67‐year‐old man presented with a 4‐month history of infra‐orbital paraesthesia. Imaging showed an expanded infra‐orbital canal, with changes extending to the vidian canal. The lesion was biopsied via an endoscopic trans‐antral approach, and a diffuse large B‐cell lymphoma was confirmed. He was managed with multi‐agent chemotherapy with a good clinical response.ConclusionsAlthough rare, primary trigeminal lymphoma is an important additional differential diagnosis to consider when assessing a new finding of unexplained trigeminal nerve paraesthesia. Central nervous system imaging should be included in the work up of unexplained trigeminal paraesthesia.
Immunophenotypic analysis of lymphocyte subsets in newborns with biotinidase deficiency
Authors: Karaoglan Murat , Nacarkahya Gulper , Keskin Mehmet , Keskin Ozlem 
Published: November 2020

AbstractBackground/AimBiotin is a vital micronutrient that plays a role in metabolic homeostasis and the regulation of innate and adaptive immune system functions. Biotinidase deficiency (BTD) leads to impairment in biotin‐dependent immune functions. This study focused on immunophenotypic analysis of lymphocyte subsets in newborns with BTD.Patients and MethodsA total of 181 (95 female and 86 male; 114 had BTD and 67 were healthy) newborns underwent biotinidase enzyme activity, molecular and lymphocyte immunophenotyping analyses. BTD is classified into four biochemical phenotypes: profound, partial, heterozygous and normal. The following lymphocyte subsets were studied in all participants: total B lymphocyte (CD19), total T lymphocyte (CD3), helper T lymphocyte (CD3/CD4), cytotoxic T lymphocyte (CTL) (CD3/CD8), natural killer T lymphocyte (CD16/56) and a T‐lymphocyte activation marker (HLA‐DR).ResultsThe percentages of lymphocyte subsets were similar in newborns with and without BTD. In all newborns with BTD, the mean CD3/CD4 levels were higher in females, while the CD3/CD8 levels were higher in males (P < .001 for each). In female and male newborns, the CD3/CD4 levels were 53.83 ± 9.46 and 16.82 ± 5.19, respectively, and the CD3/CD8 levels were 48.80 ± 8.65 and 21.48 ± 6.02, respectively. A moderate negative correlation was found between CD3/CD4 and CD3/CD8 in female and male newborns (rfemale = −0.488, rmale = −0.574, P < .001).ConclusionThis study showed that although there were no differences in the lymphocyte subsets in newborns with BTD, the CD3/CD4 levels were higher in females, and the CD3/CD8 levels were higher in males. In addition, there was a negative correlation between the CD3/CD4 and CD3/CD8 levels in both genders. Although these results indicate sexual dimorphism between CD3/CD4 and CD3/CD8 levels, whether this dissociation is unique to BTD in newborns is not fully clear.
Ask the question, be the solution: Fostering well‐being through contextualized assessment and strategy development
Authors: Petrini Laura A. , Thottathil Princy , Shih Grace , Henderson Alicia , Pasquariello Carol , Black Stephanie A. 
Published: November 2020

AbstractIn recent years, optimizing provider well‐being and mitigating the effects of physician burnout have become increasingly important in the field of medicine. These efforts are in part of consequence because of significant costs associated with provider burnout, for both individuals and their workplace. Accordingly, robust work has focused on development of strategies to decrease the incidence of burnout or mitigate its effects, including both individual efforts and systematic organizational change. This article describes the development and implementation of a unique assessment strategy to identify the driving factors hindering well‐being in our general anesthesiology division. We describe how collected data allowed us to identify important areas for improvement, build community, and target novel interventions to ultimately improve the well‐being of our division for all members. This manuscript does not describe survey results in any detail, but rather aims to present a creative application of the Hawthorne Effect as it applies to understanding physician well‐being.
Late bedtime reflects QTA30 anxiety symptoms in adolescents in a school checkup
Authors: Habukawa Chizu , Nagamitsu Shinichiro , Koyanagi Kenshi , Nishikii Yumi , Yanagimoto Yoshitoki , Yoshida Seiji , Suzuki Yuichi , Go Soken , Murakami Katsumi 
Published: November 2020

AbstractBackgroundIn adolescence, physical symptoms may develop due to psychosocial problems but such problems are not fully evaluated in school medical checkups. The aim of this study was to compare lifestyle factors with psychosomatic symptoms in adolescents using the subscales of the Questionnaire for Triage and Assessment with 30 items (QTA30) in school health checkups.MethodsThe QTA30 was used in checkups for 3,414 students from the fifth grade of primary school to the third grade of junior high school in south Wakayama prefecture. The QTA is a self‐completed questionnaire with five subscales of physical symptoms, depression symptoms, self‐efficacy, anxiety symptoms, and family function. Each subscale is divided into three groups of clinical, borderline, and healthy, based on the subscale score. Subscale scores were compared with lifestyle items of gender, grade, habits, life events, and school attendance.ResultsThe clinical rate for all subscales was significantly higher for a higher grade (P < 0.001). Anxiety symptoms were correlated with physical symptoms (r = 0.560). Anxiety and physical symptoms were significantly higher for students who went to bed at a later time with no absences in the last month and who had problems with friends and teachers (both P < 0.001). Family function correlated with self‐efficacy (r = 0.418) but not with other subscales. Study time was most related to self‐efficacy (P < 0.001).ConclusionsThe QTA30 subscale scores facilitated detection of psychosomatic stress and latent risks of psychosomatic disease at an early stage. Thus, the use of the QTA30 in a school medical checkup may permit early intervention for psychosomatic stress in adolescents.
Is the atypical hemolytic uremic syndrome risk polymorphism in Membrane Cofactor Protein MCPggaac relevant in kidney transplantation? A case report
Authors: Sánchez‐Moreno Ana , de la Cerda Francisco , Rodríguez‐Barba Adela , Fijo Julia , Bedoya Rafael , Arjona Emilia , de Córdoba Santiago Rodríguez 
Published: November 2020

AbstractaHUS is a rare disease characterized by episodes of TMA that frequently progresses to CKD and often recurs after KT. The most frequent cause of aHUS is defective regulation of complement activation because of genetic anomalies. Eculizumab interrupts the process of TMA and improves renal function. We describe one female patient with aHUS who debuted in 2005 at 3‐mo‐old with extrarenal manifestations and progressed to end‐stage kidney disease (ESKD) within a year. Her family history included several affected members with similar bad outcomes. Our patient carries a strong aHUS genetic predisposition consisting in a pathogenic gain‐of‐function mutation in complement factor B concurrent with the MCP aHUS risk haplotype MCPggaac. She received a kidney transplant in 2011 without eculizumab prophylaxis. The graft, which was negative for the MCPggaac risk haplotype, had an unexpected excellent evolution without aHUS recurrence. Different retrospective studies have shown that the risk of aHUS recurrence after KT correlates well with the genetic load of aHUS risk factors. Knowing important contribution of the MCPggaac risk haplotype to the risk of developing aHUS in Factor B mutations carriers, we speculate whether the absence of this polymorphism in the graft that our patient received may have decreased the risk of aHUS recurrence after KT.
Transplantation in pediatric aHUS within the era of eculizumab therapy
Authors: Özçakar Zeynep Birsin , Ozaltin Fatih , Gülhan Bora , Çomak Elif , Parmaksız Gönül , Baskın Esra , Topaloğlu Rezan , Kasap Demir Belde , Canpolat Nur , Yuruk Yildirim Zeynep , Demircioğlu Kılıç Beltinge , Yüksel Selçuk , Söylemezoğlu Oğuz 
Published: November 2020

AbstractaHUS is caused by the over‐activation and dysregulation of the alternative complement pathway. Data regarding outcomes of pediatric aHUS patients after kidney transplantation are still very scarce. Accordingly, the aim of this study was to describe the clinical findings and outcomes of pediatric aHUS patients after renal transplantation. This is a retrospective, multicenter study including 12 patients from the national registry system. Among the 12 patients, eight had received prophylactic eculizumab and none of those patients (except one) had experienced aHUS recurrence during a median follow‐up period of 58.5 (min‐max, 4‐94) months. Although eculizumab had been started on the day before transplantation in one of them, aHUS recurrence occurred during the transplantation procedure. Eculizumab had been stopped in only one patient who had no complement gene mutation after 35 months of therapy, and recurrence had not been observed during the 19 months of follow‐up. In three patients, maintenance doses had been spaced out without any recurrence. One additional patient with anti‐CFH antibody received only two doses of eculizumab for transplantation and had been followed for 46 months without aHUS recurrence. The remaining three patients had not received anti‐C5 therapy and none of those patients experienced aHUS recurrence during a median follow‐up period of 21 (min‐max, 9‐42) months. Prophylactic eculizumab is a safe and effective treatment for the prevention of aHUS recurrence. Eculizumab interval prolongation, discontinuation, and transplantation without eculizumab prophylaxis can be tried in selected patients with close follow‐up.
Empathy and the Value of Humane Understanding
Authors: Bailey Olivia 
Published: November 2020

AbstractEmpathy is a form of emotionally charged imaginative perspective‐taking. It is also the unique source of a particular form of understanding, which I will call humane understanding. Humane understanding consists in the direct apprehension of the intelligibility of others’ emotions. This apprehension is an epistemic good whose ethical significance is multifarious. In this paper, I focus on elaborating the sense in which humane understanding of others is non‐instrumentally valuable to its recipients. People have a complex but profound need to be humanely understood. Because we respond to others’ very real need when we pursue this sort of understanding of their emotions, empathy is best understood as itself a way of caring, rather than just a means to promote other caring behavior.
Surfactants in plant disease management: A brief review and case studies
Authors: Jibrin Mustafa O. , Liu Qingchun , Jones Jeffrey B. , Zhang Shouan 
Published: November 2020

AbstractIn plant disease management, surfactants are generally used in combination with pesticides to facilitate delivery of the pesticide chemicals to the target sites in plants, vectors, or pathogens. Their intended use is rarely for direct effect on plant pathogens. However, trends in recent studies have revealed an appreciable increase in their use for direct management of plant diseases. In this paper, we briefly review the progress made in the use of surfactants for disease management, as adjuvants and when applied for direct effect. We carried out experiments to evaluate the effect of selected synthetic surfactants (Cohere, Kinetic, Silwet‐77, and Induce) on powdery mildew in squash and bacterial spot in tomato. Results from this study showed that the effect of surfactants on these pathogens is dependent on the type of plant pathogen or disease. All tested surfactants exhibited in vitro bactericidal activity against Xanthomonas perforans, a causal pathogen of bacterial spot of tomato. In the greenhouse, Cohere significantly reduced disease severity of powdery mildew in squash compared to the untreated control. Cohere also showed promise in field trials against bacterial spot of tomato, but the other surfactants tested promoted this disease. Our studies demonstrate the importance of evaluating surfactants for their use in management of plant diseases both for direct effect and as adjuvants in tank mix.
Louïze Labé Lionnoize: the making of an early modern author
Authors: Amundsen Bergström Matilda 
Published: November 2020

AbstractIn this article, I discuss three central peritexts included in French poet Louise Labé’s Euvres de Louïze Labé Lionnoize, printed by Jean de Tournes in Lyon in 1555: the title page, the royal privilege, and a collection of celebratory poems. Arguing that the Early Modern book provided a space where women authors and their editors could engage with ongoing debates about women and their artistic capabilities, I analyse how the author figure Louise Labé is presented in these peritexts, tying that image to the contents of the book as well as to prevalent views on women authors. Highlighting the critique that a woman who published in print was likely to face, I argue that the peritexts can be connected to specific, sometimes traditional, sometimes unconventional, marketing strategies that correlate to Labé’s poetry and preface. In addition, I highlight the commercial aspects of the book, arguing that the peritexts were used to entice multiple types of readers (and buyers) to invest in the book.
Linear stability of transversely modulated finite‐amplitude capillary waves on deep water
Authors: Murashige Sunao , Choi Wooyoung 
Published: November 2020

AbstractWe investigate the three‐dimensional linear stability of the periodic motion of pure capillary waves progressing in permanent form on water of infinite depth for the whole range of wave amplitudes. After introducing a coordinate transformation based on a conformal map for two‐dimensional steady capillary waves, we perform linear stability analysis of finite‐amplitude capillary waves in the transformed space. To solve the linearized equations for small amplitude disturbances, it is assumed that the wavelengths of the disturbances in the transverse direction are much longer than those in the propagation direction and, therefore, the disturbances are weakly three‐dimensional. This assumption along with the periodicity of solutions allows us to write the linearized equations as an eigenvalue problem in matrix form. Following a perturbation theory for matrices, we expand the solutions of this eigenvalue problem in terms of a small parameter measuring the weak three‐dimensionality, and numerically obtain approximate eigenvalues. For weakly three‐dimensional superharmonic disturbances, the numerical results demonstrate that the pure capillary waves are two‐dimensionally stable, but three‐dimensionally unstable for almost all wave amplitudes. On the other hand, for subharmonic disturbances that are known to be two‐dimensionally unstable, it is found that the long‐wavelength disturbances in the transverse direction reduce the two‐dimensional growth rate near the critical amplitude beyond which the pure capillary waves are unstable.
Personality and psychopathology heterogeneity in MMPI‐2 and health‐related features in fibromyalgia patients
Authors: Gonzalez Bárbara , Novo Rosa , Peres Rodrigo 
Published: November 2020

Personality and psychopathology features may play an important role as predisposing factors for fibromyalgia (FM). However, psychological heterogeneity of FM patients has been suggested. Based on two personality psychopathology clusters, we intend to explore psychological heterogeneity in FM patients, specifically, to identify if personality features had other psychological and psychopathological correlates. Secondarily, we also want to identify if personality features have association with health‐related correlates. The participants were female FM patients (n = 56) between 30 and 60 years old. The instruments were: Minnesota Multiphasic Personality Inventory (MMPI‐2) content and supplementary scales, Fibromyalgia Impact Questionnaire (FIQ), and Numerical Rating Scale (NRS‐11). Multivariate analyses of variance (MANOVAs) identified that Cluster 2 (n = 24), characterized by a combination of negative affectivity and social inhibition, presented a more disturbed profile, with several features of symptomatic behavior, general maladjustment, and important clinical problem areas. The associations of personality variables with FM impact and self‐reported pain are null, with the exception of Disconstraint scale. In conclusion, FM patients may be very different at the psychological level, concerning personality and psychopathological features that may compromise their treatment. Personality and health‐related dimensions do not seem to be associated.
Taxation, Forced Labor, and Theft: Why Taxation is “On a Par” with Forced Labor
Authors: Moore Adam D. 
Published: November 2020

AbstractIn 1974, Robert Nozick famously claimed, “taxation of earnings is on a par with forced labor.” If we assume that forced labor is morally objectionable, something akin to slavery, then Nozick’s claim about taxation challenged the very heart of socialist redistributive liberalism. Moving through a series of cases starting with a version of J. J. Thomson’s violinist case, it will be argued that Nozick was basically correct. These cases will establish that 1) forcibly kidnapping someone and hooking them up to a violinist is immoral, 2) forcing others to provide necessities of life for you is morally objectionable, while forcing you to provide for your own necessities is not, 3) being related to the “forcer” does not mitigate the wrongness, 4) receiving benefits does not lessen the wrongness of forcing, 5) majority voting does not diminish the wrongness of forcing, 6) the reply that forced taxation does not really require any forcing—workers could choose to watch sunsets or go on assistance—fails to mitigate the wrongness of forced taxation, and finally 7) the view that income is a social construction is examined and rejected. It is concluded that most forms of taxation are immoral as they contain unjustified forcings and the seizures of value.
Art in the Time of Frugality: Scarcity, Cooperation, and Change in American Art Museums
Authors: Poling Jessica 
Published: November 2020

Funding for American art museums has undergone significant changes in the past 20 years. In particular, federal and corporate giving have substantially declined following the Great Recession. These changes impact museums’ ability to secure funding for exhibitions. This study addresses how funding scarcity affects American art museums, specifically with regard to staff’s ability to execute their own tasks and the strategies of action they use to compensate for these changes. Drawing from literature on resource scarcity, I explore how funding declines have prompted museum staff to use “strategic cooperation” as a means of diversifying limited financial resources. Moreover, using interviews with curators and development officers, I identify three cooperative strategies they may use: coordinating inter‐professional activities, pooling professional knowledge, and finding creative financial solutions. These findings add to work on resource scarcity by identifying inter‐group cooperation as a diversification strategy. More importantly, I add to this literature by specifically identifying multiple forms of strategic cooperation individuals may employ to combat resource scarcity. Finally, while literature on the arts has focused on museums’ propensity for inter‐professional conflict during times of duress, my work demonstrates that, despite this, cooperative action is a present and viable strategy in cultural organizations.
Ethnic variations in mothers’ and children’s positive and negative emotional expressions toward each other
Authors: Rudy Duane , Ispa Jean M. , Fine Mark A. , James Anthony G. 
Published: November 2020

AbstractThis study examined whether ethnicity moderated trajectories of mothers’ and children’s positive and negative emotional expressions, as well as within‐time and lagged associations between these variables. European American and Mexican American mothers’ and children’s emotional expressions toward each other were observed when children were aged 15, 25, and 37 months. Children’s positivity increased at identical rates and maternal positivity predicted subsequent levels of children’s positivity similarly in the two groups. However, Mexican American children’s negative expressivity declined at more pronounced rates than European American children. Also, whereas at 27 months, European American children’s negativity was negatively predicted by previous levels of maternal positivity, at 37 months it was predicted by previous levels of maternal negativity. Mexican American mothers’ emotional expressivity did not predict their children’s negativity. Finally, maternal negativity declined over time only among Mexican Americans. The results are interpreted with reference to ecocultural theory, the Mexican values of simpatía and respeto, the European American value of authenticity, and the fact that cultural differences become more pronounced as children age.
Treatment of invasive IMP‐4Enterobacter cloacaeinfection in transplant recipients using ceftazidime/avibactam with aztreonam: A case series and literature review
Authors: Cairns Kelly A. , Hall Victoria , Martin Genevieve E. , Griffin David W.J. , Stewart James D. , Khan Sadid F. , Abbott Iain J. , Meher‐Homji Zaal , Morrissey Catherine O. , Sia Christopher , Love Jane , Corallo Carmela E. , Bergin Peter , Sharma Ashish , Basu Gopal , Spencer Andrew , Peleg Anton Y. 
Published: November 2020

AbstractInfections caused by carbapenemase‐producingEnterobacteriaceae(CPE) are an emerging threat in both solid organ and stem cell transplant recipients. Invasive CPE infections in transplant recipients are associated with a high mortality, often due to limited therapeutic options and antibacterial toxicities. One of the most therapeutically challenging group of CPE are the metallo‐β‐lactamase (MBL)‐producing Gram‐negative bacteria, which are now found worldwide, and often need treatment with older, highly toxic antimicrobial regimens. Newer β‐lactamase inhibitors such as avibactam have well‐established activity against certain carbapenemases such asKlebsiella pneumoniaecarbapenemases (KPC), but have no activity against MBL‐producing organisms. Conversely, aztreonam has activity against MBL‐producing organisms but is often inactivated by other co‐existing β‐lactamases. Here, we report four cases of invasive MBL‐CPE infections in transplant recipients caused by IMP‐4‐producingEnterobacter cloacaewho were successfully treated with a new, mechanism‐driven antimicrobial combination of ceftazidime/avibactam with aztreonam. This novel antimicrobial combination offers a useful treatment option for high‐risk patients with CPE infection, with reduced drug interactions and toxicity.