bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring Tumor Epichaperome Expression Using [124I] PU-H71 Positron Emission Tomography as a Biomarker of Response for PU-H71 Plus Nab-Paclitaxel in HER2-Negative Metastatic Breast Cancer
Authors: Jhaveri Komal L. , dos Anjos Carlos H. , Taldone Tony , Wang Rui , Comen Elizabeth , Fornier Monica , Bromberg Jacqueline F. , Ma Weining , Patil Sujata , Rodina Anna , Pillarsetty Nagavarakishore , Duggan Susan , Khoshi Sarhe , Kadija Nathan , Chiosis Gabriela , Dunphy Mark P. , Modi Shanu 
Published: November 2020

PURPOSE Epichaperome network maintenance is vital to survival of tumors that express it. PU-H71 is an epichaperome inhibitor that binds to the ATP-binding site of HSP90 and has demonstrated antitumor activity in breast cancer xenograft models and clinical safety in patients. PU–positron emission tomography (PET) is a theragnostic imaging tool that allows visualization of the epichaperome target. In this phase Ib trial, we present safety and tolerability for PU-H71 plus nab-paclitaxel in HER2-negative patients with metastatic breast cancer (MBC) and the utility of PU-PET as a noninvasive predictive biomarker. METHODS We performed a 3 + 3 dose-escalation study with escalating PU-H71 doses and standard nab-paclitaxel. The primary objective was to establish safety and determine maximum tolerated dose (MTD)/recommended phase 2 dose. Secondary objectives were to assess pharmacokinetics and clinical efficacy. Patients could enroll in a companion PU-PET protocol to measure epichaperome expression before treatment initiation to allow exploratory correlation with treatment benefit. RESULTS Of the 12 patients enrolled, dose-limiting toxicity occurred in one patient (G3 neutropenic fever) at dose level 1; MTD of PU-H71 was 300 mg/m2 plus nab-paclitaxel 260 mg/m2 administered every 3 weeks. Common toxicities included diarrhea, fatigue, peripheral neuropathy, and nausea. PU-H71 systemic exposure was not altered by nab-paclitaxel administration. Two of 12 patients had partial response (overall response rate, 17%) and the clinical benefit rate was 42% (5 of 12). Time to progression was associated with baseline epichaperome positivity and PU-H71 peak standard uptake value (SUV), with more durable disease control observed with high epichaperome levels. CONCLUSION The combination of PU-H71 and nab-paclitaxel was well tolerated, with evidence of clinical activity. More durable disease control without progression was observed in patients with high baseline epichaperome expression. A phase II trial of this combination with PU-PET as a companion diagnostic for patient selection is currently planned.
The Effect of Cycling-specific Vibration on Neuromuscular Performance
Authors: VIELLEHNER JOSEF , POTTHAST WOLFGANG 
Published: November 2020

ABSTRACT

Purpose
This study aimed to provide an understanding of how surface-induced vibrations in cycling interfere with short-term neuromuscular performance.

Methods
The study was conducted as a cross-sectional single cohort trial. Thirty trained cyclists participated (mass = 75.9 ± 8.9 kg, body height = 1.82 ± 0.05 m, V˙O2max = 63 ± 6.8 mL·kg−1⋅min−1). The experimental intervention included a systematic variation of the two independent variables: vibration (Vib: front dropout, 44 Hz, 4.1 mm; rear dropout, 38Hz, 3.5 mm; NoVib) and cranking power (LOW, 137 ± 14 W; MED, 221 ± 18 W; HIGH, 331 ± 65 W) from individual low to submaximal intensity. Dependent variables were transmitted accelerations to the body, muscular activation (gastrocnemius medialis, gastrocnemius lateralis, soleus, vastus lateralis, vastus medialis, rectus femoris, triceps brachii, flexor carpi ulnaris, and lumbar erector spinae), heart rate, and oxygen consumption.

Results
The main findings show that the root-mean-square of local accelerations increased with vibration at the lower extremities, the torso, and the arms–shoulder system. The activation of gastrocnemius medialis, gastrocnemius lateralis, soleus, triceps brachii, and flexor carpi ulnaris increased significantly with vibration. The activation of vastus lateralis increased significantly with vibration only at HIGH cranking power. Oxygen consumption (+2.7%) and heart rate (+5%–7%) increased significantly in the presence of vibration.

Conclusions
Vibration is a full-body phenomenon. However, the impact of vibration on propulsion is limited as the main propulsive muscles at the thigh are not majorly affected. The demands on the cardiopulmonary and respiratory system increased slightly in the presence of vibration.
Long-wave infrared multi-wavelength IPDA lidar for standoff detection of chemical warfare agents: theoretical study
Authors: Cézard Nicolas , Melkonian Jean-Michel 
Published: November 2020

We discuss and evaluate the expected performance of a tunable
multi-wavelength integrated-path differential absorption lidar
operating in the long-wave infrared between 7.5 and 11 µm, for
standoff measurement of chemical agents. Interference issues with
natural gas compounds throughout the entire 7.5–11 µm band are first
discussed. Then, the study focuses on four interest species, three
warfare agents, and a simulant. A performance model is derived and
exploited to assess the expectable measurement precision of the lidar
for these four species in the integrated-path mode within a 2 min
alert time and seventeen emitted wavelengths. Measurement precisions
better than the targeted sensitivity levels look reachable at the
kilometer range with laser power below 100 mW. Performance
optimization strategies are discussed, either by adjusting the pulse
energy/pulse repetition rate for a given laser power and lidar range
or by reducing the wavelength sequence in an optimal way. Finally the
system’s receiving operating characteristic curves are derived to
describe the expected detection performance in terms of probability of
false alarm rate and probability of detection.
Tm3+ and Ho3+ colasing in in-band pumped waveguides fabricated by femtosecond laser writing
Authors: Kifle Esrom , Loiko Pavel , Romero Carolina , de Aldana Javier Rodríguez Vázquez , Zakharov Viktor , Gurova Yulia , Veniaminov Andrey , Petrov Valentin , Griebner Uwe , Thouroude Romain , Laroche Mathieu , Camy Patrice , Aguiló Magdalena , Díaz Francesc , Mateos Xavier 
Published: November 2020

We report on the first, to the best of our knowledge, in-band pumped

T
m

3
+

,

H
o

3
+

codoped waveguide (WG) laser. A depressed-index surface channel WG (type III) with a 50 µm half-ring cladding is fabricated in a 5 at. %

T
m

3
+

, 0.5 at. %

H
o

3
+

:

K
L
u

(

W
O

4

)
2

crystal by femtosecond pulse direct laser writing. Under in-band pumping by a 1679 nm Er Raman fiber laser,

T
m

3
+

and

H
o

3
+

colasing is observed in the WG and explained by bidirectional energy transfer. The maximum total output power at

∼

1942

n
m

(

T
m

3
+

)

and 2059 nm (

H
o

3
+

) is 448 mW with a slope efficiencyM of 40.6%, which is a record high for this type of WG lasers. The maximum output power of the Ho laser reaches 144 mW.
Risk factors for hydrocephalus following fourth ventricle tumor surgery: A retrospective analysis of 121 patients
Authors: Chen Tengyun , Ren Yanming , Wang Chenghong , Huang Bowen , Lan Zhigang , Liu Wenke , Ju Yan , Hui Xuhui , Zhang Yuekang 
Published: November 2020

Background and aim
Most patients who present with a fourth ventricle tumor have concurrent hydrocephalus, and some demonstrate persistent hydrocephalus after tumor resection. There is still no consensus on the management of hydrocephalus in patients with fourth ventricle tumor after surgery. The purpose of this study was to identify the factors that predispose to postoperative hydrocephalus and the need for a postoperative cerebrospinal fluid (CSF) diversion procedure.

Materials and methods
We performed a retrospective analysis of patients who underwent surgery of the fourth ventricle tumor between January 2013 and December 2018 at the Department of Neurosurgery in West China Hospital of Sichuan University. The characteristics of patients and the tumor location, tumor size, tumor histology, and preventive external ventricular drainage (EVD) that were potentially correlated with CSF circulation were evaluated in univariate and multivariate analysis.

Results
A total of 121 patients were enrolled in our study; 16 (12.9%) patients underwent postoperative CSF drainage. Univariate analysis revealed that superior extension (p = 0.004), preoperative hydrocephalus (p<0.001), and subtotal resection (p<0.001) were significantly associated with postoperative hydrocephalus. Multivariate analysis revealed that superior extension (p = 0.013; OR = 44.761; 95% CI 2.235–896.310) and subtotal resection (p = 0.005; OR = 0.087; 95% CI 0.016–0.473) were independent risk factors for postoperative hydrocephalus after resection of fourth ventricle tumor.

Conclusion
Superior tumor extension (into the aqueduct) and failed total resection of tumor were identified as independent risk factors for postoperative hydrocephalus in patients with fourth ventricle tumor.
MiR-424-5p regulates cell cycle and inhibits proliferation of hepatocellular carcinoma cells by targeting E2F7
Authors: Zhao Yichao , Zhu Chaoqian , Chang Qing , Peng Peng , Yang Jie , Liu Chunmei , Liu Yang , Chen Xiaonan , Liu Yuanguang , Cheng Ran , Wu Yijie , Wu Xiaotang , Hu Liang , Yin Jun 
Published: November 2020

Objective
This study aims to explore the mechanism of the miR-424-5p/E2F7 axis in hepatocellular carcinoma (HCC) and provide new ideas for targeted therapy of HCC.

Methods
Bioinformatics analysis was used to identify the target differentially expressed miRNA in HCC and predict its target gene. qRT-PCR was employed to verify the expression of miR-424-5p and E2F7 mRNA in HCC cells. Western blot was performed to detect the effect of miR-424-5p ectopic expression on the protein expression of E2F7. CCK-8 was used to detect proliferative activity of HCC cells and flow cytometry was carried out for analyzing cell cycle distribution. Dual luciferase reporter assay was conducted to verify the direct targeting relationship between miR-424-5p and E2F7.

Results
We observed that miR-424-5p was down-regulated in HCC cells. CCK-8 showed that overexpression of miR-424-5p inhibited cell proliferation, and flow cytometry showed that miR-424-5p could block cells in G0/G1 phase. E2F7 was up-regulated in HCC cells, and E2F7 overexpression could facilitate the proliferative ability of HCC cells and promote the cell cycle progressing from G0/G1 to S phase. Furthermore, dual-luciferase reporter assay indicated that miR-424-5p could directly down-regulate E2F7 expression. Analysis on cell function demonstrated that miR-424-5p inhibited the proliferation of HCC cells and blocked cell cycle at G0/G1 phase by targeting E2F7.

Conclusion
Our results proved that E2F7 was a direct target of miR-424-5p, and miR-424-5p could regulate cell cycle and further inhibit the proliferation of HCC cells by targeting E2F7.
Red, Autobiography of Ou Chaoquan, Ou Chaoquan (2019) (trans. D. Norman Geary)
Authors: Fei Yan 
Published: November 2020

Review of: Red, Autobiography of Ou Chaoquan, Ou Chaoquan (2019) (trans. D. Norman Geary)
London: Austin Macauley Publishers, 290 pp.,
ISBN: 978-1-52891-258-7, p/bk, £12.99
Investigasi Arus Sejajar Pantai (Longshore Current) di Daerah Abrasi Bengkulu Utara
Authors: Lubis Ashar Muda , Veronica Nia , Saputra Rio , Sinaga Juhendi , Hasanudin M. , Kusmanto Edi 
Published: November 2020

The coastal area of Serangai Village is directly facing the open sea; as a result it is vulnerable to coastal abrasion. Longshore currents can accelerate the process of coastal abrasion. The study was aimed to determine the speed and direction of current as well as the existence of the longshore current at the Serangai. Field observation was conducted on 5-7 November 2018. The results showed that the frequency distribution of current at speed of 0-10 cm/s reached 69%, and at speed of 10-20 cm/s reached 25%. The highest speed of 20-30 cm/s has a frequency of 6 %. Moreover, the direction of the majority of ocean currents is to the southeast (120o-150o), showing that the current is more likely to be parallel to the shoreline called longshore current that can accelerate shoreline Serangai Village, Bengkulu. However, further research is needed to see variability of current associated with the season (monsoon). Wilayah pesisir Desa Serangai berhadapan langsung dengan laut lepas; sehingga rentan terhadap abrasi pantai. Arus sejajar pantai dapat mempercepat proses abrasi pantai. Penelitian bertujuan untuk mengetahui kecepatan dan arah arus serta keberadaan arus sejajar pantai di Serangai. Pengamatan lapangan dilakukan pada tanggal 5-7 November 2018. Hasil penelitian menunjukkan bahwa distribusi frekuensi arus pada kecepatan 0-10 cm/s mencapai 69%, dan pada kecepatan 10-20 cm/s mencapai 25%. Kecepatan tertinggi 20-30 cm/s memiliki frekuensi 6%. Selain itu, arah arus laut mayoritas ke arah tenggara (120o-150o), menunjukkan bahwa arus lebih cenderung sejajar dengan garis pantai yang disebut arus sejajar pantai yang dapat mempercepat garis pantai Desa Serangai, Bengkulu. Namun, penelitian lebih lanjut diperlukan untuk melihat variabilitas arus yang terkait dengan musim (monsun).
Analisis Stok dan Tingkat Pemanfaatan Sumberdaya Ikan Lemadang (Coryphaena hippurus) Berdasarkan Data di Pelabuhan Perikanan Samudera Cilacap
Authors: Susila Cita , Ghofar Abdul , Saputra Suradi Wijaya 
Published: November 2020

Dolphinfish fish is one of the commodities of Indonesian waters, which is a bycatch of tuna fisheries. Lemadang fish are under considerable catching pressure and tend to increase, thus endangering their sustainability. The purpose of the study was to find out the length of first caught (Lc50%), growth parameters, mortality rate, MSY value, optimum trip (f) and lemadang fish exploitation rate. The data collected are fish length (cmFL), fish weight (kg), fish production, and fishing efforts. The data were collected once every 2 weeks during November 2019 until January 2020. The results of the study is the size of fish ranged from 41 – 125 cmFL and length at first capture (Lc50%) 75 cmFL. The long-weight relationship analysis obtained equation W=0,0000378*L2,363 with negative allometric growth pattern. The growth equation von Bertalanffy obtained Lt = L∞(1-e-1.8(t+0,343)). The total mortality 8,54 year-1 the rate of exploitation amounted to 0,8 with the peak of recruitment in August. The estimated value of MSY of Dolphinfish was 121.570 kg/year with optimum effort of 571 trip/year. The estimated value of Dolphinfish sustainable potential is 121,570 kg/year, with optimum efforts of 571 trips/year. Dolphinfish production since 2011 has exceeded its maximum sustainable yield (MSY). Utilization of Dolphinfish fish resources has been overfishing, both based on analysis of analytical models and production surplus models. Ikan Lemadang merupakan salah satu komoditi dari perairan Indonesia, yang merupakan bycatch dari perikanan tuna. Ikan Lemadang mengalami tekanan penangkapan yang cukup tinggi dan cenderung meningkat, sehingga dapat membahayakan kelestariannya. Tujuan dari penelitian adalah mengetahui ukuran pertama kali tertangkap, parameter pertumbuhan, laju mortalitas, nilai MSY, trip (f) optimum, dan tingkat eksploitasi ikan Lemadang. Data yang dikumpulkan adalah panjang cagak ikan (cmFL) dan bobot ikan (kg), volume tangkapan dan upaya penangkapan (trip), produksi ikan dan trip penangkapan. Pengambilan data dilakukan 2(dua) minggu sekali selama bulan November 2019 hingga Januari 2020. Hasil penelitian diperoleh ukuran panjang ikan berkisar 41 – 125 cmFL, dan ukuran pertama kali tertangkap (Lc50%) 75 cmFL. Persamaan hubungan panjang-bobot didapatkan W=0,0000378*L2,363,dan sifat pertumbuhan alometrik negatif. Persamaan pertumbuhan von Bertalanffy ikan Lemadang didapatkan Lt = L¥ (1-e-1,8(t+0,343)). Puncak rekrutmen terjadi pada bulan Agustus. Laju mortalitas total (Z) adalah 8,54 per tahun, mortalitas penangkapan (F) = 6,81/tahun, dan tingkat eksploitasi (E=F/M) sebesar 0,8. Nilai dugaan potensi lestari ikan Lemadang sebesar 121.570 kg/tahun, dengan upaya optimum sebesar 571 trip/tahun. Produksi ikan Lemadang sejak tahun 2011 sudah melebihi tingkat produksi maksimum lestari (MSY)-nya. Pemanfaatan sumber daya ikan Lemadang sudah overfishing. baik berdasarkan analisis model analitik maupun model surplus produksi.
Struktur Komunitas Ikan Karang dan Tutupan Karang pada Terumbu Buatan Artificial Patch Reef (APR)
Authors: Munasik Munasik , Nugroho Aldion Adin , Hartati Retno , Sabdono Agus , Sugiyanto Sugiyanto , Sugianto Denny Nugroho 
Published: November 2020

Artificial Patch Reef (APR) have been applied as a new method for Biodiversity Conservation Program at Panjang Island, Jepara since 2015. Previous study suggested that design and location of artificial reefs installation affected to abundance of reef fishes, associated with the artificial reef. This study aims to investigated community structure of reef fishes associated to artificial patch reef comparing to reef fishes in nearby natural reefs. Assessment of coral reef condition on two habitats were conducted on July 2019, after 4 years deployment. The results show that artificial patch reefs with a percentage of live coral cover are less than half of natural coral reefs, and have succeeded in increasing the abundance of reef fish with nearly the same density and community structure resembling reef fish in natural coral reefs. The similarity in community structure of the two habitats is probably due to the similarity in habitat type and morphology of the hard corals. The results indicate that Artificial Patch Reef (APR) reefs have increased the coral cover of Acropora branching and resulted in increased reef fish abundance which is compatible with reef fish communities associated with natural coral reefs around it. Aplikasi metode baru terumbu buatan Artificial patch Reef (APR) pada Program Konservasi Bioiversitas Pulau Panjang, Jepara telah dilakukan sejak 2015. Hasil studi menunjukkan bahwa pemilihan desain dan lokasi pemasangan terumbu buatan yang tepat akan meningkatkan kelimpahan ikan karang. Tujuan penelitian ini adalah untuk mengetahui keberhasilan penerapan terumbu buatan APR melalui kelimpahan ikan karang yang berasosiasi pada terumbu buatan dan terumbu karang alami di sekitarnya. Penilaian kondisi terumbu karang tersebut telah dilakukan pada Juli 2019 setelah 4 (empat) tahun pemasangan terumbu buatan. Hasil studi menunjukkan bahwa terumbu buatan dengan persentase tutupan karang hidup lebih kecil, separuhnya dari tutupan pada terumbu karang alami telah berhasil meningkatkan kelimpahan ikan karang dengan densitas hampir sama dan struktur komunitasnya menyerupai ikan karang yang berasosiasi dengan terumbu karang alami. Kesamaan struktur komunitas kedua habitat kemungkinan akibat kesamaan tipe habitat dan morfologi karang keras penyusunya. Hasil ini mengindikasikan bahwa terumbu buatan Artificial patch Reef (APR) telah meningkatkan tutupan karang bercabang Acropora dan berakibat terhadap meningkatnya kelimpahan ikan karang yang sesuai dengan komunitas ikan karang yang berasosiasi dengan terumbu karang alami di sekitarnya.
Three Projects in the New Law and Finance
Authors: Awrey Dan 
Published: November 2020

Abstract
This article is a review of Katharina Pistor’s book The Code of Capital: How the Law Creates Wealth and Inequality. Using modern derivatives markets as a case study, it explores the important contributions – and limits – of Professor Pistor’s story about the role of the law and lawyers as the master coders of capitalism. This exploration reveals three distinct projects: a historical coding project, an intellectual decoding project, and a policy-driven recoding project. The fact that these projects are so intricately intertwined posed unique challenges for scholars, but also holds out a potential blueprint for a new law and finance.
How Man Became the Measure: An Anthropological Defense of the Measure Doctrine in theProtagoras
Authors: Maksymchuk Oksana 
Published: November 2020

AbstractIn theTheaetetusSocrates provides an elaboration and discussion of Protagoras’ measure doctrine, grounding it in a “secret doctrine” of flux. This paper argues that the anthropology of the myth in theProtagorasprovides an earlier, very different way to explain the measure doctrine, focusing on its application to civic values, such as “just,” “fine,” and “pious.” The paper shows that Protagoras’ explanation of the dual etiology of virtue – that it is acquired both by nature and by nurture – tracks the two meanings of “anthropos” in his formulation of the measure doctrine, as “humankind” and “individual human.” On Protagoras’ account, humankind’s survival can be explained by the fact that humans share shame and justice, which enables them to live together in cities.
False hyperthyroidism caused by interference in immunoassays
Authors: Jiménez García Clara , Ortega Fernández Piedad , Torregrosa Quesada María Eugenia , González Bueno Victoria , Botella Belda María Teresa , Guerra Rocío Alfayate 
Published: November 2020

Abstract

Objectives
Immunoassays used to assess thyroid function are vulnerable to different types of interference that may affect clinical decision-making.

Case presentation
We report the case of a 37-year-old woman who developed iatrogenic hypothyroidism after having received radioiode therapy who visited our hospital for her annual checkup. The patient was asymptomatic, without signs suggestive of thyroid disease. However, laboratory analysis proved otherwise: thyrotropin (TSH) 7.75 mU/L, thyroxine (FT4) >7.7 ng/dL.

Conclusions
The inconsistency between her clinical symptoms and the biochemistry data raised the possibility of a methodological interference. A thorough evaluation of the main causes of interference was conducted in the laboratory to exclude the presence of interference in TSH and FT4. Finally, different interfering agents were identified, which affected free thyroid hormone and TSH determination.
Lactose tolerance test as an alternative to hydrogen breath test in the study of lactose malabsorption
Authors: Sendino Teresa , Sandúa Amaia , Calleja Sofía , González Álvaro , Alegre Estibaliz 
Published: November 2020

Abstract

Objectives
Lactose malabsorption is generally assessed by hydrogen breath testing (HBT). However, this test is not recommended in patients with high baseline hydrogen concentrations (H2B). In addition, breath testing is not recommended in the current situation created by the COVID-19 pandemic, due to the potential infectiveness of the samples. The objective is to assess concordance between HBT and lactose tolerance test (LTT) depending on H2B concentrations.

Methods
A total of 430 patients (40 years, Q1–Q3 = 28–54 years; 66.7% women) suspected of lactose malabsorption were included in the study. Breath and heparinized blood samples were collected at baseline and sequentially after the intake of 50 g of lactose, to measure hydrogen in breath and glycemia in blood, respectively.

Results
H2B was <10 ppm in 69.5% of subjects; 10–20 ppm in 14.7%; and >20 ppm in 15.8% of subjects. In patients with H2B <20 ppm, concordance between HBT and LTT was moderate and consistently improved when the cut-off in LTT was set at 15 mg/dL. The increase in hydrogen and glucose correlated negatively (r=−0.389; p<0.05). The increase in glycemia during LTT was not influenced by H2B levels obtained in HBT.

Conclusions
LTT emerges as an alternative to HBT to assess lactose malabsorption in the presence of high H2B levels or when breath testing is not recommended by the circumstances. The best concordance was obtained when the cut-off for LTT was set at 15 mg/dL.