bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tick‐Borne Encephalitis Virus Surveillance—Vaccination‐ and Infection‐Induced Seroprevalences in Western Austria 2024
Authors: Siller Anita , Chitimia‐Dobler Lidia , Hitzl Wolfgang , Astl Manfred , Schennach Harald , Fraunberger Peter , Cadamuro Janne , Borde Johannes P. , Willeit Peter , Dobler Gerhard , Mink Sylvia 
Published: December 2024

ABSTRACTReported tick‐borne‐encephalitis (TBE) cases have been increasing in Western Austria, but no data are available on vaccination‐ and infection‐specific seroprevalence. This study aimed to estimate current TBEV‐seroprevalence in the region and inform prevention programs by comparing anti‐NS1‐based‐incidence rates with reported case numbers and vaccination coverage. Between December 2023 and February 2024, serum samples from 4619 blood donors in Western Austria were collected and analyzed using TBEV‐ and WNV‐IgG‐ELISA assays. Seropositive samples were tested with a TBEV‐anti‐NS1‐IgG‐ELISA to distinguish infections from vaccinations. Borderline samples were retested with serum neutralization and triple‐NS1‐assays. The overall anti‐TBEV‐IgG‐seroprevalence was 80.1% (95%CI 78.9–81.3); 2.7% (95%CI 2.3–3.2) of donors tested positive for anti‐TBEV‐NS1 IgG antibodies, indicating previous infection. The notified incidence rate in Western Austria was 2.7/100 000/year, compared to 136.2/100 000/year based on anti‐TBEV‐NS1‐seropositive donors, denoting a substantial number of unreported cases (mean manifestation index 1.9%). The number of donors with TBEV‐infections varied considerably by district, highlighting potential hotspots for TBEV‐infections. The high anti‐NS1‐based, estimated annual TBE incidence rates show significant differences between districts, highlighting the need for targeted prevention programs. The high rate of undiagnosed TBE cases further suggests that estimated anti‐NS1‐based incidence rates should be considered when defining high‐risk areas.
Maduramicin ammonium impairs autophagic flux through activating AMPK‐mediated eIF2α‐ATF4 endoplasmic reticulum stress pathway in skeletal muscle
Authors: Chen Xin , Xie Xin , Liu Chang , Chen Lin , Zhang Meng , Zhang Yumei 
Published: December 2024

AbstractBACKGROUNDMaduramicin ammonium (MA), a widely used coccidiostat, has been reported to cause skeletal muscle degeneration in animals and even humans. In this study, we explore the underlying mechanism of its toxicity in skeletal muscle.RESULTSFirst, we observed that MA impaired autophagic flux which was evidenced by increased protein level of LC3‐II and p62 in skeletal myoblast C2C12 and L6 cell lines and rectus femoris muscle tissues of rats and broilers. Then, we found that MA induced eIF2α phosphorylation and ATF4 expression in the cells and tissues. Co‐treatment with ISRIB attenuated MA‐induced LC3‐II and p62 in C2C12 and L6 cells, suggesting that MA‐induced eIF2α‐ATF4 pathway contributed to impairment of autophagic flux in the cells. Lastly, we showed that MA activated AMPK signaling in skeletal muscle, since the phosphorylation of AMPK was increased by MA treatment in skeletal myoblast cell lines and muscle tissues. Furthermore, in AMPK downregulated C2C12 cells, MA‐induced LC3‐II, ATF4 and phosphorylation of eIF2α was reversed, supporting that AMPK was involved in the regulation of the eIF2α‐ATF4 pathway and autophagic flux during MA exposure.CONCLUSIONOur findings showed that MA impairs autophagic flux through activating the AMPK‐induced eIF2α‐ATF4 pathway in skeletal muscle. © 2024 Society of Chemical Industry.
Stapled Arterial Divestment in Surgery for Locally Advanced Pancreatic Cancer
Authors: Kotecha Krishna , Chui Juanita , Brown Kai , Mittal Anubhav , Samra Jaswinder 
Published: December 2024

ABSTRACTBackgroundPancreatic adenocarcinoma has a predisposition to invade the neural tissue surrounding the superior mesenteric artery (SMA). Before the advent of neoadjuvant chemotherapy (NAC), any invasion of this tissue was often considered as unresectable disease. Currently, patients who respond favourably to NAC have potentially resectable disease. There is debate over the exact technique of removing this shell of tumour tissue surrounding the SMA, and whether it is comparable to arterial resection and reconstruction.MethodsWe describe a technique of en bloc arterial divestment in which an endovascular stapler combined with sharp dissection is used to divide the shell of periadventitial SMA tissue.ConclusionsIn patients with locally advanced disease, the technique of arterial divestment can be safely performed where the tumour is not invading below the external elastic lamina. This allows complete tumour resection without incurring the higher morbidity and mortality associated with SMA resection.
How Does Green Knowledge Sharing Improve Sustainable Business Performance?
Authors: Zairbani Abdulkader , J. P Senthil Kumar 
Published: December 2024

ABSTRACTThis study aims to investigate the mediating impact of green innovation (GI) on the relationship between green knowledge sharing (GKS) with sustainable business performance (SBP) and sustainable competitive strategy (SCA). Furthermore, we investigate the moderator effect of green organizational culture (GOC) on the relationship between GKS and SBP. A conceptual model structured with six hypotheses that are tested through articulated study, the study with an empirical approach is developed and applied to 350 questionnaires of middle‐level managers in Bangalore city and rural areas. The results of the study indicate that GKS has a significant impact on SBP and SCA. While GOC plays an insignificant moderator role on the relationship between GKS and SBP. In contrast, GI plays a positive mediation impact on the relationship between GKS with SBP and SCA. In addition, GS has a positive impact on SCA.
Improving Accuracy of Gridded Livestock Mapping by Combining Trend Modeling and Residual Assignment
Authors: Wu Tianjun , Gao Peng , Zhang Shenlin , Cheng Tong , Wang Yuxia 
Published: December 2024

ABSTRACTThe accurate distribution of livestock is a fundamental data set upon which sustainable land development in agricultural and pastoral areas can be promoted. Nevertheless, the current gridded livestock mapping methods exhibit considerable scope for improvement in accuracy, given that the issue of residual assignment has not been addressed effectively. We attempt to propose a combinatorial methodological framework that decomposes gridded livestock mapping into two stages, trend modeling, and residual assignment, through the perspective of uncertainty. Investigating the relative efficacy of different combinations of methods within the framework aims to identify the optimal total mapping solution. Ridge regression (RR), geographically weighted ridge regression (GWRR), and random forest (RF) methods with varying characteristics were used to represent the trend modeling component and combined with area‐to‐point kriging interpolation based on spatial autocorrelation for residual assignment, respectively. The Inner Mongolia Autonomous Region from China provides a multi‐scale case validation of the framework. The experimental results show that GWRR has high robustness and prediction accuracy for predicting livestock distribution trends across scales. By using residual assignment optimization as a post‐processing tool, the total accuracies of the three trend models were improved in different degrees, with the greatest accuracy gains obtained by RF (RMSE reduced by 13.731 and MAE reduced by 12.247, in units/km2). Therefore, the combined two‐stage methodological framework proposed in this study can effectively improve the accuracy of gridded mapping. This provides an effective complement to current gridded livestock mapping, thereby facilitating more sustainable land use, ecological environmental protection, and livestock development.
Carbazole, Fluorene, and Silafluorene Bearing Non‐Fullerene Acceptors: Synthesis, Characterization, and Performance in Organic Photovoltaic Devices
Authors: Balcı Seher , Hosseini Shadi , Demirgezer Elif , Yaşa Mustafa , Çırpan Ali , Toppare Levent 
Published: December 2024

AbstractDue to their tunable energy levels, ability for intense light absorption, stability and ease of purification, non‐fullerene acceptors (NFAs) have significantly contributed to the progress of organic photovoltaics (OPVs). Herein, a series of newly designed and synthesized NFAs specifically tailored are presented for OPV applications. A new class of NFAs possessing carbazole, fluorene, silafluorene derivatives, and benzothiadiazoles are synthesized. The electrochemical and optical investigations are conducted thoroughly. The utilization of these new materials with commercial donor polymers P3HT and PTB7‐Th in OPVs shows their potential applications for future studies. The optimal performance is achieved with an inverted structured OPV device, which demonstrates a power conversion efficiency (PCE) of 3.77%, an open‐circuit voltage (VOC) of 1.06 V, a short‐circuit current (JSC) of 9.66 mA cm−2, and a fill factor (FF) of 37.08%.
Biomimetic nanosystems based on cell membranes (BNCMs) for cancer immunotherapy
Authors: Wang Yixi , Huang Xianzhou , Wu Qinjie , Gong Changyang 
Published: December 2024

AbstractWith the development of nanosystems, they are gradually utilized to ameliorate diverse cancer therapies. Specifically for immunotherapy, most nanosystems are elaborately designed to initiate the self‐sustaining “cancer immunity cycle (CIC)” to elicit the immune response. However, owing to the highly complex circulatory environment, nanosystems may face issues like nonspecific nanoparticle uptake and rapid clearance, leaving enormous room for advancement. For employing the biomimetic design in nanosystems, biomimetic nanosystems based on cell membranes (BNCMs) inherit various functional molecules from source cells, permitting precise tumor targeting, enhancing blood circulation, and conferring more desired functionality for a more robust immune response. To take full advantage of the BNCMs, understanding their functions in cancer immunotherapy is essential. In this review, the unique properties of BNCMs derived from various cells and main preparation strategies are introduced. Subsequently, the recent advances of BNCMs for improving cancer immunotherapy are discussed from the aspects of their roles in particular stages of the CIC, and the working mechanisms of the outer cell membranes are highlighted. Finally, along with the analysis of existing bottlenecks for clinical translation, some suggestions for the future development of BNCMs are put forward.
Implications of increased spatial and trophic overlap between juvenile Pacific salmon and Sablefish in the northern California Current
Authors: Daly Elizabeth A. , Chasco Brandon E. , Morgan Cheryl A. , Burke Brian J. , Osborne Kaitlyn E. , Draper Douglas L. 
Published: December 2024

Abstract

Objective
The study was designed to assess long-term variability in the distribution of juvenile Pacific salmon Oncorhynchus spp. and Sablefish Anoplopoma fimbria. The study also evaluated whether Sablefish and Pacific salmon shared food resources and looked to characterize Sablefish during an understudied period of their life cycle.

Methods
To meet the objectives, the study used data from 26 years of surface trawls conducted in Oregon and Washington coastal waters (1998–2023). Spatial–temporal models were used to measure changes in abundance and distribution of Pacific salmon and Sablefish along with covariates of ocean temperature. The study evaluated trophic characteristics of Pacific salmon and Sablefish from 2020 for differences. The temporal variation in size and diets of Sablefish were also analyzed, along with energy density of fish caught in 2020.

Result
The spatial–temporal model demonstrated that there has been a nearshore expansion of juvenile Sablefish over the past 26 years that was correlated with increased ocean temperature. The nearshore expansion of Sablefish resulted in increased spatial and trophic overlap with juvenile Pacific salmon. While feeding in nearshore waters, juvenile Sablefish demonstrated competitive feeding advantages over juvenile Pacific salmon during a critical phase of salmonid early marine life history. Juvenile Sablefish exhibited significant ontogenetic diet and energetic shifts, and even the smallest (68–80 mm fork length) were piscivorous.

Conclusions
If juvenile Sablefish numbers continue to increase relative to Pacific salmon, they could exert more competitive pressure, especially if food resources become limited. Pacific salmon may experience adverse effects from competition, regardless of whether or not juvenile Sablefish, which have recently expanded into nearshore waters, successfully recruit to the adult population.
Predicting the high intensity focused ultrasound focus in vivo using acoustic radiation force imaging
Authors: Shi Xinwang , Zhao Fenglong , Feng Lian , Liu Yijing , Zhou Xiaowei 
Published: December 2024

AbstractBackgroundOne big challenge in the noninvasive high‐intensity focused ultrasound (HIFU) surgery is that the location and shape of its focus is unpredictable at the preoperative stage due to the complexity of sound wave propagation. The Acoustic Radiation Force Impulse (ARFI) imaging is a potential solution to this problem, but artifacts resulting from shear wave propagation remain to be solved.PurposeIn this study, we proposed avoiding those artefacts by applying the ARFI technique at a high imaging frame rate within a very short time before the shear waves start to propagate.MethodsUsing single transmission with a convex imaging probe, two ultrafast imaging modalities (the diverging wave and the wide beam), were developed in the ARFI framework, and their reliabilities were validated on a nylon string phantom by the centroid tracking method borrowed from ultrasound localization microscopy (ULM). The proposed ARFI method was tested on a clinically equivalent HIFU system under different acoustic radiation intensities by in‐vitro, ex‐vivo and in‐vivo experiments. In three experimental scenarios, we delivered short HIFU stimulation pulses at varying acoustic powers to induce tissue motion within the focal region. At each experimental site, both diverging wave and wide‐beam imaging techniques were employed for motion estimation. Based on the focus prediction derived from the motion estimation, HIFU ablation treatment was performed. The treated samples were then incised to examine the damaged areas. Additionally, ultrasound B‐mode images were acquired before and after the procedure and saved for analysis.ResultsQuantitative analysis showed that the ARFI with wide beam imaging was able to predict the HIFU focus preoperatively, only with 1 to 3 mm of errors in focal central location, and less than 23% of percentage errors in focal area in most cases. However, the diverging wave imaging failed to predict the HIFU focus due to its low signal‐to‐noise ratio.ConclusionsIn conclusion, the inherent shear wave artefacts in ARFI for predicting the HIFU focus can be successfully avoided by carefully designing the imaging strategy and its working sequence. This ARFI technique was validated through a series of experiments on a clinically equivalent HIFU system, which demonstrated its capability in assisting surgical planning.
Validity and Reliability of the 6‐min Pegboard and Ring Test in Patients With Duchenne Muscular Dystrophy
Authors: Maden Çağtay , Karabulut Demet Gözaçan , Yiğit Sedat 
Published: December 2024

ABSTRACTIntroduction/AimsTests for assessing upper extremity (UE) functional capacity in patients with Duchenne muscular dystrophy (DMD) are limited. This study aimed to evaluate the validity and reliability of the 6‐min pegboard and ring test (6PBRT) as a practical tool for this purpose.MethodsChildren with DMD (n = 22) were evaluated using the 6PBRT for UE functional capacity, the Quick Disabilities of the Arm, Shoulder, and Hand (Q‐DASH) for functionality, the Pediatric Quality of Life Inventory (PedsQL) for quality of life, and a dynamometer for handgrip strength and UE muscle strength.ResultsThe 6PBRT showed excellent test–retest reliability, with an intraclass correlation coefficient (ICC) of 0.978 (95% confidence interval, 0.946–0.984). A very strong positive correlation was observed between the test and retest 6PBRT mean scores (r = 0.981). The mean 6PBRT score exhibited moderate‐to‐strong correlations with handgrip strength (r = 0.653, r = 0.646, right/left, respectively), muscle strength (shoulder flexors [r = 0.793, r = 0.797, right/left, respectively], shoulder abductors (r = 0.763, r = 0.743, right/left, respectively), elbow flexors [r = 0.743, r = 0.755, right/left, respectively]), mean Q‐DASH score (r = −0.555), and mean PedsQL score (r = 0.611).DiscussionThe 6PBRT appears to be a valid and reliable measure for assessing upper extremity functional capacity in patients with DMD. This test is suitable for patients who are able to lift both hands above their heads.
Trial Registration: NCT06174025
Cyclic Lateral Response of Large‐Diameter Monopiles in Soft Clays Using Bounding Surface‐Based Analytical p‐y Curves
Authors: Cheng Xinglei , Yang Jinhui , Wang Piguang , El Naggar Mohamed Hesham , Wang Mingyuan , Lu Qun , Sun Rui 
Published: December 2024

ABSTRACTThe p‐y curve method provides a relatively simple and efficient means for analyzing the cyclic response of horizontally loaded piles. This study proposes a p‐y spring element based on a bounding surface p‐y model, which can be readily implemented in Abaqus software using the user‐defined element (UEL) interface. The performance of these p‐y spring elements is validated by simulating field tests of laterally loaded piles documented in the literature. The developed spring element effectively replicates the nonlinear hysteresis, displacement accumulation, and stiffness degradation observed in soft clay. Subsequently, a finite element model of a large‐diameter monopile is established using the proposed spring element. A comprehensive numerical investigation is conducted to explore both the monotonic and cyclic responses of large‐diameter monopiles in soft clays. The results are presented and discussed in terms of pile head load–displacement curves, the evolution of rotation angles at the mud surface, and cyclic p‐y curves. Additionally, empirical formulas are proposed to predict the evolution of cumulative rotation angles and peak bending moments under both one‐way and two‐way cyclic loading conditions. The results provide valuable insights into the mechanism of pile–soil interaction under lateral cyclic loading.
Macroscopic and Mesoscopic Damage Characteristics and Energy Evolution Laws of Rock Mass With Double Arcuate Fractures Under Uniaxial Compression
Authors: Ren Qingyang , Gao Senlin , Xiao Songqiang , Meng Xin , Li Zhongyao 
Published: December 2024

ABSTRACTIn order to reveal the influence of double arc‐shaped fissure dip angles on the macro‐micro failure and energy evolution laws of rock masses, a numerical model of red sandstone was firstly established using the PFC2D. Moreover, mesoscopic parameters of the numerical model were calibrated based on the uniaxial compression tests on intact and single straight fissure red sandstone specimens. Then, particle flow simulation tests of red sandstone with different arc‐shaped fissure dip angles were carried out. The results show that the peak strength and elastic modulus both increase with the increase of arc‐shaped fissure dip angle α, exhibiting an oblique shear‐tensile failure pattern. Six types of cracks evolved during the instability and rupture of the rock mass with double arc‐shaped fissures. The macroscopic fissures in the rock mass ultimately penetrate along the extension direction of the arc‐shaped fissures. As the arc‐shaped fissure dip angle α increases, the crack evolution is positively correlated with the acoustic emission (AE) of the specimen. When approaching instability failure, the AE ringing count rapidly increases. There is a critical angle limit inflection point for the total energy absorbed by the rock between 60° and 75°, with a total energy increase of about 54%. During instability failure, it is dominated by dissipative energy, with elastic energy as a supplement. This article derived a damage constitutive model of red sandstone with different arc‐shaped fissure dip angles, revealing the damage laws of red sandstone under different arc‐shaped fissure dip angles.
On the Use of Block Low Rank Preconditioners for Primal Domain Decomposition Methods
Authors: Bovet Christophe , Gauthier Théodore , Gosselet Pierre 
Published: December 2024

ABSTRACTThis article investigates the use of the block low rank (BLR) factorization, recently proposed in the MUMPS solver, to define efficient and cheap preconditioners for primal domain decomposition methods, such as the Balancing Domain Decomposition method (BDD) and its adaptive multipreconditioned variant. To be scalable, these methods are equipped with an augmentation projector built from the local preconditioners nullspaces. The determination of these nullspaces is a complex task in the case of ill conditioned system, the use of block low rank compression makes this task even more complex as MUMPS' automatic detection no longer works properly. Two alternatives based on incomplete factorization with a well‐chosen Schur complement are proposed. Also, the first massively parallel implementation of the adaptive multipreconditioned BDD solver (AMPBDD) is introduced. The performance of the methods is assessed with two weak scalability studies on problems up to 24,576 cores and about 790 millions of unknowns, on the Sator and Topaze supercomputers. BLR preconditioning proves to be an interesting strategy both in terms of memory usage and time to solution for reasonably conditioned problems.
Only photos on my best side, please! Implications of bilateral asymmetry of the iliac auricular surface in non‐adult individuals for sex estimation
Authors: Monge Calleja Álvaro M. , Aranda Claudia M. , Luna Leandro H. 
Published: December 2024

AbstractThis study aims to address the overlooked effect of bilateral asymmetry for sex estimation in non‐adult paired bone structures. Using a recently developed method, disparities between right and left iliac auricular surfaces (AuSs) were quantified, also verifying the effectiveness between sides regarding the percentages of cases correctly assigned. A sample of 418 AuSs belonging to 209 individuals aged 5 gestational months to 18 years (113 males and 96 females) from the Coimbra, Lisbon, and Granada Identified skeletal collections, were studied. They were grouped into two large age cohorts (≤12 y.o. and 12.1–18 y.o.) based on the onset of menarche. The significant and distinct hormonal fluctuations between sexes in ≤2 y.o. individuals compelled an additional separation. Locomotion issues also imposed grouping individuals for comparison in non‐bipedal (≤1 y.o.) and those who were still achieving emerging gait milestones (1.1–6 y.o.). Overall agreements between sides, sexes, age cohorts, and morphometric variables were compared using Cohen's κ and intraclass correlation coefficients, while chi‐square and Kolmogorov–Smirnov tests were applied for statistically significant evaluation. Asymmetry directionality was calculated through standardized directional and total asymmetry scores. Slight asymmetries between sides were identified, becoming the pre‐pubertal left AuS more useful for non‐adult female sexing. Metric variables work better in males, possibly due to the higher variability found in females. Both sexes display a marked age‐related change in asymmetry during puberty (12.1–18 y.o.), with a predominance of the right side in females and of the left side in males. Possible explanations for the identified pubertal abrupt shifts are discussed considering the various developmental biomechanical milestones. This pioneering study reinforces the complexity of somatic growth and development that characterizes non‐adult phenotype, calling for further refinement of sexing methods considering bilateral asymmetry, and for complementary studies that deepen the study of dextralization and its repercussions in adults.