bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penentuan Kriteria dan Strategi Dalam Menghadapi Peperangan Kepulauan dengan Pendekatan Dematel - ANP
Authors: Herdiawan Didit , Ahmadi Ahmadi , Wibowo Haryanto 
Published: March 2020

TNI Angkatan Laut merupakan salah satu komponen pertahan Negara di laut. Dihadapkan dengan dinamika lingkungan strategis maka TNI AL harus mampu untuk meningkatkan kemampuan pertahanan untuk dapat mengatasi ancaman peperangan permukaan, peperangan amfibi, peperangan khusus (anti nubika, anti teror dan lawan sabotase bawah air), serta kemampuan Anglamil (Angkutan Laut Militer). Melihat kondisi geografis Indonesia yang merupakan Negara Kepulauan dengan beraneka ragam konfigurasi geografi yang dimiliki, maka TNI AL dapat menjadikan kondisi geografis ini sebagai strategi dalam pertempuran yaitu Peperangan Kepulauan. Berdasarkan latarbelakang tersebut maka perlu adanya penentuan kriteria yang secara objektif dapat mempengaruhi dari model strategi TNI AL dalam usaha untuk memenangkan Peperangan Kepulauan. Sehingga diperoleh pilihan strategi yang tepat untuk melaksanakan Peperangan Kepulauan. Untuk membahas permasalahan tersebut digunakan pendekatan DEMATEL (Decision Making Trial and Evaluation Laboratory) untuk melihat hubungan keterkaitan antar kriteria dan subkriteria. Kriteria utama yang diperoleh adalah Konstelasi Geografi, Taktik Peperangan Kepulauan, Postur Kekuatan TNI AL, Kekuatan Negara Ancaman dan Peran Dawilhanla. Kemudian dilakukan perancangan model dalam pemilihan strategi Peperangan Kepulauan dengan pendekatan ANP (Analytic Network Process). Hasil dari pengolahan data yang dilakukan diperoleh bobot prioritas alternatif yang terpilih yaitu Decisive Battle (0,06369), Blockade (0,06120) dan Fleet in Being (0,04800). Selain itu dilaksanakan analisis BOCR (Benefit, Opportunity, Cost and Risk) diperoleh hasil berdasarkan skenario standar Fleet in Being dengan bobot 0,56233, skenario pesimis terpilih alternatif Decisive Battle dengan bobot 0,09169 dan skenario realistis terpilih alternatif Decisive Battle dengan bobot 0,02237.Kata Kunci: DEMATEL, ANP, Peperangan Kepulauan, Analisis BOCR (Benefit, Opportunity, Cost and Risk).
Effect of climatic factors on the seasonal fluctuation of human brucellosis in Yulin, Northern China
Authors: Liu Kun , Yang Zurong , Liang Weifeng , Guo Tianci , Long Yong , Shao Zhongjun 
Published: March 2020

Abstract
Background: Brucellosis is a serious public health problem primarily affecting livestock workers. The strong seasonality of the disease indicates that climatic factors may play important roles in the transmission of the disease. However, the associations between climatic variability and human brucellosis are still poorly understood. Methods: Data for a 14-year series of human brucellosis cases and seven climatic factors were collected in Yulin City from 2005 to 2018, one of the most endemic areas in northern China. Using cross-correlation analysis, the Granger causality test, and a distributed lag non-linear model (DLNM), we assessed the quantitative relationships and exposure-lag-response effects between monthly climatic factors and human brucellosis. Results: A total of 7,103 cases of human brucellosis were reported from 2005 to 2018 in Yulin City with a distinct peak between April and July each year. Seasonal fluctuations in the transmission of human brucellosis were significantly affected by temperature, sunshine duration, and evaporation. The effects of climatic factors were non-linear over the 6-month period, and higher values of these factors usually increased disease incidence. The maximum separate relative risk (RR) was 1.36 (95% confidence interval [CI], 1.03–1.81) at a temperature of 17.4 °C, 1.12 (95% CI, 1.03–1.22) with 311 hours of sunshine, and 1.18 (95% CI, 0.94–1.48) with 314 mm of evaporation. In addition, the effects of these three climatic factors were cumulative, with the highest RRs of 2.27 (95% CI, 1.09–4.57), 1.54 (95% CI, 1.10–2.18), and 1.27 (95% CI, 0.73–2.14), respectively. Conclusions: In Yulin, northern China , variations in climatic factors, especially temperature, sunshine duration, and evaporation, contributed significantly to seasonal fluctuations of human brucellosis within 6 months. The key determinants of brucellosis transmission and the identified complex associations are useful references for developing strategies to reduce the disease burden.
Ups and downs of drug rehab among women: a qualitative study
Authors: boroumandfar zahra , kianpour masoud , afshari maryam 
Published: March 2020

Abstract
Background: due to the increasing importance of addicted women and the need to pay particular attention to this vulnerable group, and more awareness of women-specific addiction prevention and rehab programs among authorities. Objectives: In this content analysis of qualitative study we explored experiences of the women’s experience of the ups and downs of drug rehab Methods: 30 participants (addicted women) were selected through purposive and theoretical sampling until data saturation. Data collection was conducted through semi structured interviews. Conventional content analysis was utilized to analyze the transcribed interviews. Results: Based on analysis of the obtained results, the experience of women from the ups and downs of leaving the drug abuse yielded two themes and nine sub-themes. The themes were “the need for emancipation” and “Sinking factors”. Conclusions: It is concluded that addiction rehab strategies can only lead the addicted women to a brighter life when, along with open-hearted assistance by the families, women-specific rehab centers are established to help them meet their specific needs. Keywords: Substance Use, Lived Experience, Addiction disorders, Women's Health, qualitative study
Who were the tuberculosis patients who died precociously due to the disease in southern Brazil? A retrospective cohort study.
Authors: Santos Danielle Talita dos , Alves Luana Seles , New Luiz Henrique Arroyo , Crispim Juliane Almeida , Alves Josilene Dália , Ramos Denisse Andrea Cartagena , Alonso Jonas Bodini , Assis Ivaneliza Simionato de , Ramos Antonio Vieira , Dessunti Elma Mathias , Pinto Ione Carvalho , Palha Pedro Fredemir , Arcêncio Ricardo Alexandre , Nunes Carla 
Published: March 2020

Abstract
BACKGROUND: A diagnosis of tuberculosis (TB) does not necessarily mean that the disease will be treated successfully, as death still occurs among those who are diagnosed by health services. The study aimed to identify the TB patients who died precociously due to the disease and associated factors in southern Brazil. METHODS: We conducted a retrospective cohort study, where all deaths from TB were gathered, including cases of TB/HIV coinfection (ICD A15.0-A15.9 and ICD B20.0), which occurred between 2008 and 2015 in southern Brazil. After bivariate analysis, techniques for survival analysis were applied, including the Kaplan-Meier test and Cox’s regression, from which the mean, median and CI95% of survival (in days) were estimated; the hazard ratio (HR) was obtained and the associated causative factors were identified. RESULTS: A total of 143 patients were analysed: 83 (58%) of them had a diagnosis of TB (ICD A15.0 to A19) and 60 (42%) were diagnosed with TB/HIV (ICD B20.0) in basic death cause. The first group (only TB) had a median survival of 21 days, and the second group (TB/HIV) had a median survival of 34 days; however, the difference was not statistically significant. The median survival for the whole sample was 23 days; 82 (57.3%) of the patients died within 30 days after diagnosis, and 101 (71.3%) died within 60 days after diagnosis (minimum survival 2 day; maximum 349 days; standard deviation (SD) = 69.5 and mean = 52.1 days). Additionally, the alcohol use alcohol use (HR=1.65, CI95%=1.03-2.68) and other comorbidities (HR=1.79, CI95%=1.13 - 2.84) were related precocious deaths. CONCLUSION: Most of the deaths occurred precociously (within two or one months), which indicates that the diagnosis was made too late, when the disease was already at an advanced stage. The use of alcohol and other comorbidities were related with precocious deaths. Although diagnosis and treatment are free in Brazil and the patients had received a diagnosis, they died. Early, sensitive diagnosis, with social support and comprehensive care might reduce early mortality among patients with addiction problems.
Post-hospital medical respite care for homeless people in Denmark: A randomized controlled trial and cost-utility analysis.
Authors: Bring Camilla Nygaard , Kruse Marie , Ankarfeldt Mikkel , Brünés Nina , Pedersen Maja , Petersen Janne , Andersen Ove 
Published: March 2020

Abstract
Background : Being homeless entails higher mortality, morbidity, and prevalence of psychiatric diseases. This can lead to more frequent and expensive use of health care services. Medical respite care enables an opportunity to recuperate after a hospitalization and has shown a positive effect on readmissions, but little is known about the cost-effectiveness of medical respite care for homeless people discharged from acute hospitalization. Therefore, the aim of the present study was to investigate the cost-effectiveness of a 2-week stay in post-hospital medical respite care.

Methods : A randomized controlled trial and cost-utility analysis, from a societal perspective, was conducted between April 2014 and December 2015. Homeless people aged >18 years with an acute admission were included from 10 different hospitals in the Capital Region of Denmark. The intervention group (n=53) was offered a 2-week medical respite care stay at a Red Cross facility and the control group (n=43) was discharged without any extra help (usual care), but with the opportunity to seek help in shelters and from street nurses and doctors in the municipalities. The primary outcome was the difference in health care costs 3 months following inclusion in the study. Secondary outcomes were change in health-related quality of life and health care costs 6 months following inclusion in the study. Data were collected through Danish registries, financial management systems in the municipalities and at the Red Cross, and by using the EQ-5D questionnaire.

Results : After 3 and 6 months, the intervention group had €4,761 (p=0.10) and €8,515 (p=0.04) lower costs than the control group, respectively. The higher costs in the control group were mainly related to acute admissions. Both groups had minor quality-adjusted life year gains.

Conclusions : This is the first randomized controlled trial to investigate the cost-effectiveness of a 2-week medical respite care stay for homeless people after hospitalization. The study showed that a medical respite care stay for homeless people is cost-effective. Furthermore, this study illustrates that it is possible to perform research with satisfying follow-up with a target group that is hard to reach.

Trial registration : ClinicalTrials.gov Identifier: NCT02649595
The hospice as a learning environment: A follow-up study of a death education intervention that involved high-school students and the community
Authors: Testoni Ines , Sblano Fabio Vito , Palazzo Lorenza , Pompele Sara , Wieser Michael Alexander 
Published: March 2020

Abstract
Background

The theme of death in Western society has been removed from everyday life and replaced with specialized medical language. Such censorship does not reduce the fear of death, especially among young people, and it limits the possibility to elaborate on experiences linked to death, generating negative effects, especially in cases of traumatic grief. The objective of this follow-up study was to detect how and if experiences of death education changed the relationship between the community and a local hospice. Furthermore, it was stressed the theme of representation of death, in order to see whether participants were able to remind any possible attitude change following the project. Finally, it was analysed how they considered how they remembered the effect of the elaboration of the trauma caused by the suicide of a student.

Methods

This was a qualitative research study based on semi-structured interviews with palliative care professionals and teachers of students who had taken part in a death education intervention 3 years earlier. The interviews were examined through thematic analysis.

Results

The results confirmed the efficacy of the death education intervention initiated 3 years earlier. The education initiative contributed to modifying the students’ and teachers’ perspectives of end-of-life professionals and their understanding of the structures within which palliative care is implemented. It also modified the participants’ perspectives on the representation of death and promoted a new outlook on life. The hospice staff also perceived a change in the attitudes of the community, and this change had a positive impact on their everyday work.

Conclusions

This study confirmed the usefulness of creating continuity between a hospice and the community through a school education initiative. The death education project provided an educational space in which it was possible to elaborate on experiences linked to death and to re-evaluate and appreciate the structures of end-of-life care and the professionals who work in the area.

Keywords: Hospice, Palliative care, Death education, Adolescents, Suicide.
The interaction between serum uric acid and triglycerides level on blood The interaction between serum uric acid and triglycerides level on blood pressure in middle-aged and elderly individuals in China: result from a large national cohort study
Authors: Zhang Lin , Li Jin-long , Guo Lei-lei , Li Hong , Li Dan , xu guang 
Published: March 2020

Abstract
Background: The purpose of the research was to explore the extent of interaction between triglycerides (TG) and serum uric acid (SUA) level with blood pressure (BP) in middle-aged and elderly individuals in China.
Methods: Data were selected from the China Health and Retirement Longitudinal Study (CHARLS), a cross-sectional study. 3345(46.99%) men with average ages of 60.24 ± 9.24 years and 3774 (53.01%) women with average ages of 59.91 ± 9.95 years were included in the study. Differences between gender, or between categories of blood pressure levels were evaluated by t-test or chi-square test. The adjusted associations between various characteristics and BP status were first compared using linear regression models, as appropriate. Then, A general linear model adjusted for confounding factors(socio-demographic characteristics, health behaviors , medical history) metabolic measures [C-reactive protein(CRP), hemoglobin A1c (HbA1c), fasting plasma glucose(FPG), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol(HDL-C), estimated glomerular filtration rate(eGFR), body mass index(BMI)]) was used to examine the synergistic effect of SUA and TG level on BP in middle-aged and elderly individuals in China.
Results: Age-adjusted partial Pearson’s correlation coefficient showed that SUA and TG level positively correlated with both systolic blood pressure (SBP) and diastolic blood pressure (DBP) in both men and women. Multiple linear regression analysis showed the TG level was significantly and positively associated with SBP and DBP in both men (SBP: β =0.068, P =0.001; DBP: β =0.064, P=0.002) and women (SBP: β =0.061, P =0.002; DBP: β =0.084, P=0.000), but SUA were significantly and positively associated with SBP in both men (SBP: β =0.047, P =0.013) and women (SBP: β =0.040, P =0.028), regardless of other confounding factors. After adjusting for related potential confounders, evidence of interaction between SUA and TG level on SBP (men: β =-1.090, P =0.726; women: β =-0.692, P=0.861) and DBP (men: β=-1.026, P =0.572; women: β =-0.794, P =0.842) was not observed.
Conclusion: The interaction effect of SUA and TG level on BP was not observed in our study. Moreover, high SUA level was significantly associated with DBP, while high TG level was strongly related to both DBP and SBP.
Production and characterization of avian crypt-villus enteroids and the effect of chemicals
Authors: Acharya Mohan , Arsi Komala , Donoghue Annie , Liyanage Rohana , Rath Narayan C 
Published: March 2020

Abstract
Background: Three-dimensional models of cell culture such as organoids and mini organs accord better advantage over regular cell culture because of their ability to simulate organ functions hence, used for disease modeling, metabolic research, and the development of therapeutics strategies. However, most advances in this area are limited to mammalian species with little progress in others such as poultry where it can be deployed to study problems of agricultural importance. In the course of enterocyte culture in chicken, we observed that intestinal mucosal villus-crypts self-repair and form spheroid-like structures which appear to be useful as ex vivo models to study enteric physiology and diseases. Results: The villus-crypts harvested from chicken intestinal mucosa were cultured to generate enteroids, purified by filtration then re cultured with different chemicals and growth factors to assess their response based on their morphological dispositions. Histochemical analyses using marker antibodies and probes showed the enteroids consisting different cell types such as epithelial, goblet, and enteroendocrine cells typical to villi and retain functional characteristics of intestinal mucosa.Conclusions: We present a simple procedure to generate avian crypt-villous enteroids containing different cell types. Because the absorptive cells are functionally positioned outwards, similar to the luminal enterocytes, the cells have better advantages to interact with the factors present in the culture medium. Thus, the enteroids have the potential to study the physiology, metabolism, and pathology of the intestinal villi and can be useful for preliminary screenings of the factors that may affect gut health in a cost-effective manner and reduce the use of live animals.
Real-world questions and concerns about disease-modifying antirheumatic drugs (DMARDs): a retrospective analysis of questions to a medicine call center
Authors: Masri Hiba EL , Hollingworth Samantha , Driel Mieke van , Benham Helen , McGuire Treasure 
Published: March 2020

Abstract
Background Disease modifying antirheumatic drugs (DMARDs) have transformed the treatment of numerous autoimmune and inflammatory diseases but their perceived risk of harm be a barrier to use.Methods In a retrospective mixed-methods study, we analysed conventional (c) and biologic (b) DMARDs-related calls and compared them with rest of calls (ROC) from consumers to an Australian national medicine call center operated by clinical pharmacists from September 2002 to June 2010. This includes the period where bDMARDs became available on the Pharmaceutical Benefits Scheme, the government-subsidized prescription medicines formulary. We compared caller and patient demographics, enquiry types and motivation to information-seek for both cDMARDs and bDMARDs with ROC, using a t-test for continuous data and a chi-square test for categorical data. We explored call narratives to identify common themes.Results There were 1,547 calls involving at least one DMARD. The top three cDMARD enquiry types were side effects (27.2%), interactions (21.9%), and risk versus benefit (11.7%). For bDMARDs, the most common queries involved availability and subsidized access (18%), mechanism and profile (15.8%), and side effects (15.1%). The main consumer motivations to information-seek were largely independent of medicines type and included: inadequate information (44%), wanting a second opinion (23.6%), concern about a worrying symptom (18.8%), conflicting information (6.9%), or information overload (2.3%). Question themes common to conventional and biological DMARDs were caller overemphasis on medication risk and the need for reassurance. Callers seeking information about bDMARDs generally overestimated effectiveness and focused their attention on availability, cost, storage, and medicine handling.Conclusion Consumers have considerable uncertainty regarding DMARDs and may overemphasise risk. Patients cautiously assess the benefits and risks of their DMARDs but when new treatments emerge, they tend to overestimate their effectiveness.
Study on the relationship between Cardio-cerebrovascular events and the level of Atherosclerosis evaluated by Heart-brain Integrated CTA
Authors: Author) Huan Yu(Former Corresponding , Zhang Yue , Zhu Dong , Author) Kuai Duan(New Corresponding , Hu Yi , Song Chunhua 
Published: March 2020

Abstract
Background: To establish a one-stop cardio-cerebral vascular scanning technique based on double-source helical CT by analyzing the relationship between the nature of coronary artery, extracranial and extracranial vascular plaque, the degree of lumen stenosis and the occurrence and development of cardio-cerebrovascular disease (CCVD). Methods: the plaque properties, vascular stenosis degree, and plaque quantitative analysis results of coronary artery, extracranial and intracranial segments of coronary artery, extracranial and intracranial carotid artery in 39 patients who underwent combined heart-brain CTA scanning were analyzed. The correlation between the load degree of cardio-cerebrovascular plaque and cardio-cerebrovascular events was analyzed comprehensively. Results ：there were significant differences in age, high-density lipoprotein, diabetes, hypertension, smoking, plaque nature, plaque location, plaque composition and NIHSS score between the two groups. Conclusion: the combination of heart and brain CTA can help to establish the best clinical predictive model to prevent and stop the occurrence and development of coronary heart disease and stroke in time.
Correlation between reticulum ribosome-binding protein 1 (RRBP1) overexpression and prognosis in cervical squamous cell carcinoma
Authors: Zhu Jiaqi , Zhao Ruixue , Xu Wei , Ma Jing , Ning Xin , Ma Rong , Meng Fanling 
Published: March 2020

Abstract
Purpose: The aim of this study was to investigate the relationship between endoplasmic reticulum ribosomal binding protein 1 (RRBP1) expression in cervical squamous cell carcinoma tissues and its poor prognosis. RRBP1 is a nascent transporter on the rough endoplasmic reticulum. Its function is to regulate the transport and secretion of proteins in cells, and to relieve endoplasmic reticulum (ER) stress, thereby promoting tumor cell proliferation.Methods: The expression levels of RRBP1 in 96 cervical squamous cell carcinoma tissues were detected by immunohistochemistry. Western blot and qRT-PCR were used to compare the expression levels of RRBP1 in cervical squamous cell carcinoma tissues and normal cervical tissues. Then the chi-square test was used to analyze the results of immunohistochemistry. Finally, the Kaplan-Meier method was used to analyze the results by log-rank test and Cox regression (proportional risk model).Result: The overexpression of RRBP1 in cervical squamous cell carcinoma tissues was related to FIGO stage (P=0.030), tissue differentiation (P=0.047), lymph node metastasis (P=0.031), and was not related to the patient age (P=0.667). Univariate survival analysis showed that the prognosis was associated to the expression level of RRBP1 (P=0.045) and lymph node metastasis (P=0.001). Analysis of multi-factor survival cox model proved that RRBP1 was an independent prognostic factor. Conclusion: RRBP1 was overexpressed in cervical squamous cell carcinoma tissues, indicating that RRBP1 may be a new tumor marker for early diagnosis, treatment and prognosis of cervical squamous cell carcinoma, and it will provide help for individualized treatment and prognosis of cervical squamous cell carcinoma in the future.