bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bilateral Plunging Ranulas in South Auckland: Evidence for a Genetic Basis
Authors: Yin Tary , Jain Prabha , Ahmad Zahoor , Harrison John D. , Morton Randall P. 
Published: February 2020

ObjectivesWe present a series of bilateral plunging ranula patients to examine the etiology, diagnosis, treatment, and prognosis of this condition.MethodsA retrospective chart review was performed on all cases of plunging ranula treated at the Department of Otolaryngology–Head and Neck Surgery, Counties Manukau District Health Board, New Zealand, between 2001 and 2019.ResultsThere were 17 patients with bilateral plunging ranulas from a total of 187 plunging ranula patients. Eight patients were of Pacific Island descent; six were Maori; and three were Asian. There were no European patients with bilateral plunging ranulas. There were three types of bilateral plunging ranula patients: 1) Metachronous plunging ranulas—Five patients presented with a unilateral plunging ranula with no evidence of a contralateral plunging ranula on initial imaging. Despite negative contralateral imaging findings, these patients developed a clinically evident contralateral plunging ranula 21 to 61 months later. 2) Synchronous plunging ranulas detected on imaging—Eight patients presented with a clinically evident unilateral plunging ranula but also had a contralateral plunging ranula detected on imaging. 3) Clinically evident synchronous plunging ranulas—Four patients presented with bilateral clinically evident plunging ranulas, which were also evident on imaging. Twelve patients underwent bilateral transoral sublingual gland excision and plunging ranula evacuation.ConclusionAll patients with a unilateral plunging ranula should be advised of the potential for developing contralateral disease, and this should be emphasized in patients of Pacific Island, Maori, and Asian descent.Level of Evidence4 Laryngoscope, 131:73–77, 2021
Management of Parkinson's Disease During Pregnancy: Literature Review and Multidisciplinary Input
Authors: Young Caitlin , Phillips Rhiannon , Ebenezer Louise , Zutt Rodi , Peall Kathryn J. 
Published: February 2020

ABSTRACTBackgroundThere are no standardized clinical guidelines for the management of Parkinson's disease (PD) during pregnancy. Increasing maternal age would suggest that the incidence of pregnancy in women diagnosed with PD is likely to increase.ObjectiveTo evaluate the evidence for the treatment of PD during pregnancy and to canvass opinion from patients and clinical teams as to the optimum clinical management in this setting.MethodsThis involved (1) a literature review of available evidence for the use of oral medical therapy for the management of PD during pregnancy and (2) an anonymized survey of patients and clinical teams relating to previous clinical experiences.ResultsA literature review identified 31 publications (148 pregnancies, 49 PD, 2 parkinsonism, 21 dopa‐responsive dystonia, 32 restless leg syndrome, 1 schizophrenia, and 43 unknown indication) detailing treatment with levodopa, and 12 publications with dopamine agonists. Adverse outcomes included seizures and congenital malformations. Survey participation included patients (n = 7), neurologists (n = 35), PD nurse specialists (n = 50), obstetricians (n = 15), and midwives (n = 20) and identified a further 34 cases of pregnancy in women with PD. Common themes for suggested management included optimization of motor symptoms, preference for levodopa monotherapy, and normal delivery unless indicated by obstetric causes.ConclusionsThis study demonstrates the paucity of evidence for decision‐making in the medical management of PD during pregnancy. Collaboration is needed to develop a prospective registry, with longitudinal maternal and child health outcome measures to facilitate consensus management guidelines.
Novel IRF6 mutations in Chinese Han families with Van der Woude syndrome
Authors: Yu Yanqin , Wan Yatao , Qin Chuanqi , Yue Haitang , Bian Zhuan , He Miao 
Published: February 2020

AbstractBackgroundInterferon Regulatory Factor 6 (IRF6) gene encodes a member of the IRF family of transcription factors. Mutations in IRF6 cause Van der Woude Syndrome (VWS), which is the most common malformation of syndromic orofacial clefts in humans.MethodsHere, we performed sequencing studies of six families with VWS in the Chinese Han population. The entire IRF6‐coding region and the exon–intron boundaries including exons 3–8 and part of exon 9 were screened among all the collected family members by Sanger sequencing.ResultsWe found a novel splice site variant c.175‐6T>A, two novel missense variants (p.Lys66Arg and p.Pro107Thr), in addition with a previously reported missense variant (p.Leu87Phe), which were all located in and nearby exon 4 of IRF6. Meanwhile, a novel frameshift variant p.G257Vfs*46 in exon 7 of IRF6 was also detected. All the mutations presented to be co‐segregated in each family.ConclusionOur study has advanced the understanding of the genetic architecture of VWS and provides the basis for genetic counseling, antenatal diagnosis, and gene therapy of high risk groups.
Overvaluation of Shape and Weight and Associated Features in Patients Without Eating Disorders Seeking Treatment for Obesity
Authors: Dalle Grave Riccardo , Misconel Arianna , Fasoli Deborah , Calugi Simona 
Published: February 2020

ObjectiveThis study aimed to evaluate the presence of the overvaluation of shape and weight and its associated features in patients with obesity but no eating disorder who were seeking treatment from a specialist unit.MethodsOverall, 1,134 patients with obesity but no Diagnostic and Statistical Manual of Mental Disorders eating disorder diagnosis were included. The Eating Disorder Examination interview was administered by expert clinicians to assess the eating disorder psychopathology and overvaluation of shape and weight. Patients also completed the Symptom Check List‐90‐Revised and the 36‐Item Short Form Health Survey to assess general psychopathology and quality of life, respectively.ResultsRoughly 20% of the patients with obesity presented with clinical overvaluation of shape and weight, which was associated with the female gender, higher expected weight loss, more severe eating‐related psychopathology, higher general psychopathology, and lower mental quality of life. Linear and logistic regression analyses indicated that the clinical variables independently correlated with overvaluation of shape and weight in these patients were female gender, Eating Disorder Examination Eating Concern subscale score, and 36‐Item Short Form Health Survey mental component summary score.ConclusionsThese findings are sufficient to justify routine assessment of overvaluation of shape and weight in patients seeking treatment for obesity.
Red cell alloimmunization: A 2020 update
Authors: Castleman James S. , Kilby Mark D. 
Published: February 2020

AbstractManagement of maternal red cell alloimmunization has been revolutionized over the last 60 years. Advances in the prevention, screening, diagnosis, and treatment of alloimmune‐induced fetal anemia make this condition an exemplar for contemporary practice in fetal therapy. Since survival is now an expectation, attention has turned to optimization of long‐term outcomes following an alloimmunized pregnancy. In this review, the current management of red cell alloimmunization is described. Current research and future directions are discussed with particular emphasis on later life outcomes after alloimmune fetal anemia.
Subfunctionalization of phytochrome B1/B2 leads to differential auxin and photosynthetic responses
Authors: Carlson Keisha D. , Bhogale Sneha , Anderson Drew , Zaragoza‐Mendoza Alondra , Madlung Andreas 
Published: February 2020

AbstractGene duplication and polyploidization are genetic mechanisms that instantly add genetic material to an organism's genome. Subsequent modification of the duplicated material leads to the evolution of neofunctionalization (new genetic functions), subfunctionalization (differential retention of genetic functions), redundancy, or a decay of duplicated genes to pseudogenes. Phytochromes are light receptors that play a large role in plant development. They are encoded by a small gene family that in tomato is comprised of five members: PHYA, PHYB1, PHYB2, PHYE, and PHYF. The most recent gene duplication within this family was in the ancestral PHYB gene. Using transcriptome profiling, co‐expression network analysis, and physiological and molecular experimentation, we show that tomato SlPHYB1 and SlPHYB2 exhibit both common and non‐redundant functions. Specifically, PHYB1 appears to be the major integrator of light and auxin responses, such as gravitropism and phototropism, while PHYB1 and PHYB2 regulate aspects of photosynthesis antagonistically to each other, suggesting that the genes have subfunctionalized since their duplication.
Evaluation of a Game Based Tele Rehabilitation Platform for In‐Home Therapy of Hand‐Arm Function Post Stroke: Feasibility Study
Authors: Szturm Tony , Imran Zoya , Pooyania Sepideh , Kanitkar Anuprita , Mahana Bhuvan 
Published: February 2020

BackgroundThere is a need for innovation to improve compliance and accessibility of rehabilitation programs for individuals with acquired brain injuries. A computer game‐assisted tele‐rehabilitation platform (GTP) has been developed to address this need. With the novel application of a miniature inertial computer mouse and taking advantage of the wide variety of computer games, the GTP can provide engaging exercises for rehabilitation of upper extremity motor skills.ObjectiveTo determine the feasibility and acceptability of the game‐assisted home exercise program for upper extremity rehabilitation for people with stroke. The treatment effect was also measured after 16 weeks of intervention.DesignA feasibility study.SettingCollege of Rehabilitation Science, University of Manitoba.ParticipantsTen stroke clients.InterventionParticipants received three to four initial clinically supervised therapy sessions for training with the game assisted therapy program. Once trained, participants continued the program at the home for 16 weeks, four times per week.Main Outcome MeasuresFeasibility was evaluated based on retention rate and compliance. Semistructured interviews after the completion of the program were done to assess acceptability of the program. Quantitative analysis included (1) the Wolf Motor Function Test A and B and (2) a computerized performance‐based assessment of specific object manipulation tasks that required a combination of finger, wrist, elbow and shoulder motion.ResultsFindings demonstrated the feasibility and acceptability of the home tele‐rehab program. Eight of the 10 participants fully complied with the 16‐week exercise program. Two participants had difficulty with computer operations and did not complete the program. For the eight participants who completed the program, there was a substantial improvement from pre‐ to postintervention.ConclusionAlthough some difficulties with the technology were reported, the findings demonstrate feasible trial procedures, acceptable game‐assisted task‐oriented home training with a high compliance rate and positive outcomes. These findings and the theoretical evidence direct the next phase of a full‐scale randomized controlled trial.
A double homogeneously weighted moving average control chart for monitoring of the process mean
Authors: Abid Muhammad , Shabbir Aroosa , Nazir Hafiz Zafar , Sherwani Rehan Ahmed Khan , Riaz Muhammad 
Published: February 2020

AbstractIn the service and manufacturing industry, memory‐type control charts are extensively applied for monitoring the production process. These types of charts have the ability to efficiently detect disturbances, especially of smaller amount, in the process mean and/or dispersion. Recently, a new homogeneously weighted moving average (HWMA) chart has been proposed for efficient monitoring of smaller shifts. In this study, we have proposed a new double HWMA (DHWMA) chart to monitor the changes in the process mean. The run length profile of the proposed DHWMA chart is evaluated and compared with some existing control charts. The outcomes reveal that the DHWMA chart shows better performance over its competitor charts. The effect of non‐normality (in terms of robustness) and the estimation of the unknown parameters on the performance of the DHWMA chart are also investigated as a part of this study. Finally, a real‐life industrial application is offered to demonstrate the proposal for practical considerations.
Vogt–Koyanagi–Harada disease during chemoimmunotherapy for non‐small cell lung cancer
Authors: Kurono Yuri , Takeda Takayuki , Kunimatsu Yusuke , Tani Nozomi , Hashimoto Izumi , Hirose Kazuki 
Published: February 2020

AbstractVogt–Koyanagi–Harada disease (VKHD) is a rare systemic granulomatous autoimmune disease that affects melanocyte‐rich organs such as eye, inner ear, meninges, skin, and hair. VKHD leads to chronic uveal inflammation accompanied by a decline in visual acuity in some patients when appropriate corticosteroid treatment was not initiated in an early phase. Immune checkpoint inhibitors (ICIs) are widely used in the treatment of several kinds of cancers and chemoimmunotherapy has become the standard of care in the first‐line treatment of non‐small cell lung cancer (NSCLC). While ICIs induce immune‐related adverse events, drug‐induced VKHD is quite rare with only four reports in the ICI monotherapy; three patients with melanoma and one patient with NSCLC. We describe the first case of VKHD during chemoimmunotherapy including pembrolizumab in a patient with NSCLC, which was successfully treated with corticosteroid without any sequela.
Legacy PCB building remediation
Authors: Hamper Martin J. 
Published: February 2020

AbstractPolychlorinated biphenyls (PCBs) came onto the scene as an environmental threat quickly after they were discovered in humans and wildlife by Jensen in 1966. By October 1970, it was reported that PCBs were “truly ubiquitous pollutants” as PCBs were found at detectable concentrations in environmental samples throughout the world. Before 1971, the U.S. Environmental Protection Agency (EPA) reported that 26% of PCBs sold were used in open‐end use applications, such as caulks, sealants, plasticizers, surface coatings, ink, adhesive, and carbonless paper. Processing and distribution of PCBs in commerce were largely banned in the U.S. after July 1979 with certain continued uses authorized by the EPA. While PCBs were banned a long time ago, the ban had no immediate tangible effect on the continued use of regulated levels of PCBs in buildings constructed before the bans were implemented. Legacy buildings with PCB‐containing building materials continue to represent potential sources of indoor air, dust, outdoor air, and soil contamination. Where PCBs are present in building materials, they have the potential to pose a risk to building occupants. Proper removal of PCB‐containing materials is a highly effective approach to abating the risk. The removal can range from targeting specific building PCB‐containing materials through demolition of the building. Engineering and administrative controls can also be useful tools when addressing the risks posed by PCB‐containing materials.
Fuzzy rule‐based inference in system dynamics formulations
Authors: Sabounchi Nasim S. , Triantis Konstantinos P. , Kianmehr Hamed , Sarangi Sudipta 
Published: February 2020

AbstractIn this research, we broaden the scope of system dynamics formulations by building on a previously proposed approach to bridge fuzzy logic with dynamic modeling. Our methodology illustrates how to formulate fuzzy dynamic variables in a meaningful way. We highlight several modeling challenges, including the selection of a fuzzification and defuzzification method, their implementation in a system dynamics formulations and the validation of the results. We use a physician prescription decision‐making model substructure as an example, and apply the fuzzy rule‐based inference system to determine how a patient is categorized as “low‐risk,” “average‐risk” or “high‐risk.” We emphasize various interpretation challenges and suggest careful selection of the fuzzy operators and defuzzification method, to ensure that the defuzzified values behave reasonably in a dynamic context.Copyright © 2020 System Dynamics Society
Stimulation of the oxygen consumption by photobiomodulation in the chicken embryo chorioallantoic membrane during hypoxia
Authors: Gerelli Emmanuel , Wagnières Georges , Joniová Jaroslava 
Published: February 2020

AbstractThe main objective of this project is to study the effects of photobiomodulation (PBM) on the oxygen consumption in the in vivo chick's embryo chorioallantoic membrane (CAM) under hypoxia to improve understanding of the mechanisms involved in PBM therapy of various conditions, including strokes and ischemic wounds. Protoporphyrin IX (PPIX), produced endogenously after administration of aminolevulinic acid, was used to probe the oxygen partial pressure (pO2) in the CAM by time‐resolved spectroscopy of its delayed fluorescence. This approach enables exploring and optimizing conveniently different radiometric and spectral parameters at play in PBM. Interestingly, as PPIX is produced in the mitochondria, an organelle playing a key role in cell respiration, and then diffuses in different compartments, the pO2 can be determined in different (sub‐) cellular/tissue locations. Our results showed that PBM applied between 6 and 16 minutes (5 mW/cm2) after the beginning of hypoxia with light at 730 or 820 nm sustains the oxygen consumption in the CAM for more than one hour, an effect that is not observed in control eggs. This may explain the positive effects induced by PBM in hypoxic tissues, including those that are subject to ischemia‐reperfusion injuries.
Translanguaging and Latinx Bilingual Readers
Authors: García Ofelia 
Published: February 2020

AbstractThe traditional monolingual and monoglossic perspective of literacy and biliteracy is compared with the perspective offered by translanguaging. The author explores how the monolingual and monoglossic view of literacy has been responsible for the failure of many Latinx bilingual students. A translanguaging perspective turns its attention toward the language actions of a bilingual reader and away from the language of a written text. Focusing on the actions of three Latinx bilingual readers—a pre‐reader, an elementary school student, and a middle school student—the author explores how bilingual readers leverage their translanguaging, turning what are said to be static monolingual texts into multilingual/multimodal ones. Through the actions of three Latinx readers in different types of educational contexts, the author shows how literacy educators can take steps to acknowledge bilingual readers’ translanguaging and enter with them into a translanguaging space to do literacy.
Dynamic analysis of oil‐water two‐phase flow for a multiple‐fractured horizontal well with multiple finite‐conductivity fractures in triple media carbonate reservoir
Authors: Wang Yong , Tao Zhengwu , Yang Kun , Ma Xin , Tian Donghong , Feng Zonghong 
Published: February 2020

AbstractCarbonate reservoir is one of the important reservoir in the world. Because of the characteristics of carbonate reservoir, horizontal well and acid fracturing have become a key technology for efficiently developing carbonate reservoir. Establishing corresponding mathematical models and analyzing transient pressure behaviors of this type of well‐reservoir configuration can provide a better understanding of fluid flow patterns in formation as well as estimations of important parameters. A mathematical model for a oil‐water two‐phase flow multiple‐fractured horizontal well with multiple finite‐conductivity fractures in triple media carbonate reservoir by conceptualizing vugs as spherical shapes is presented in this article. A semi‐analytical solution is obtained in the Laplace domain by using source function theory, Laplace transformation, and superposition principle. Analysis of transient pressure responses indicates that nine characteristic flow periods of multiple‐fractured horizontal wells with multiple finite‐conductivity fractures in triple media carbonate reservoir can be identified. Parametric analysis shows that water saturation of matrix, vug and fracture system and acid fracture, fracture half‐length, fracture number, fracture spacing and acid fracture conductivity can significantly influence the transient pressure responses of multiple‐fractured horizontal wells with multiple finite‐conductivity fractures in triple media carbonate reservoir. The model presented in this article can be applied to obtain important parameters pertinent to reservoir or fracture by type curve matching, and it can also provide useful information for optimizing fracture parameters.
Non‐uniformly loaded stack of moving elastic antiplane shear cracks
Authors: Tupholme G. E. 
Published: February 2020

AbstractA stack of moving, non‐uniformly loaded, parallel, antiplane shear strip cracks within an isotropic elastic solid is analyzed, by exploiting an extended dislocation layer technique using moving screw dislocations. Detailed closed‐form expressions are obtained and discussed for the stress components at general points of the deformation that is created. Their variations with the polar angle near a crack tip are investigated and a neat representation of the corresponding novel, comprehensive, stress intensity factor is deduced. Illustrative numerical results are graphically presented. The occurrence of the phenomena of crack branching and crack shielding are observed for particular values of the geometrical parameters and speed of the cracks. Comparisons with some corresponding special cases are provided as validation of these more general results.
The parameter identification in the Stokes system with threshold slip boundary conditions
Authors: Haslinger Jaroslav , Mäkinen Raino A. E. 
Published: February 2020

AbstractThe paper is devoted to an identification of the slip bound function g in the Stokes system with threshold slip boundary conditions assuming that g depends on the tangential velocity . To this end the optimal control approach is used. To remove its nonsmoothness we use a regularized form of the slip conditions in the state problem. The mutual relation between solutions to the original optimization problem and the problems with regularized states is analyzed. The paper is completed by numerical experiments.
Introduction – LGBT Questions and the Family
Authors: Digoix Marie 
Published: February 2020

AbstractThe past decades have seen significant changes in the way non heterosexual sexualities are regulated in European countries. In a moment of ongoing transitions, the interdisciplinary research presented focuses on aspects related to homosexuals rights and the way LGBT individuals deal and perceive the impact that the presence (or absence) of laws has on their intimate lives.The evolutions in family rights in European laws and the balance towards equal rights, whether you are homosexual or heterosexual, are first detailed with an analysis of typical sequences found in a legal survey.Demographic analyses enrich these aspects in dealing with registration and parenting. Statistical analyses of same-sex partnerships and same-sex marriages show frequencies of registration together with a focus on parenting linked to the partnership status.In the next chapters, same-sex families are specifically studied in their daily life in France, Iceland and Italy through qualitative data. It investigates from a legal point of view and from a social perspective, what is at stake in the changing life of homosexuals in the field of parenting, what brings to everyday life the support of the law and what its absence implies.The Postface opens towards the future of LGBT research.