bluuebunny/crossref_metadata_2025_split huggingface dataset:
Newly diagnosed glioblastoma in geriatric (65 +) patients: impact of patients frailty, comorbidity burden and obesity on overall survival
Authors: Schneider Matthias , Potthoff Anna-Laura , Scharnböck Elisa , Heimann Muriel , Schäfer Niklas , Weller Johannes , Schaub Christina , Jacobs Andreas H. , Güresir Erdem , Herrlinger Ulrich , Vatter Hartmut , Schuss Patrick 
Published: September 2020

Abstract
Object
Increasing age is a known negative prognostic factor for glioblastoma. However, a multifactorial approach is necessary to achieve optimal neuro-oncological treatment. It remains unclear to what extent frailty, comorbidity burden, and obesity might exert influence on survival in geriatric glioblastoma patients. We have therefore reviewed our institutional database to assess the prognostic value of these factors in elderly glioblastoma patients.

Methods
Between 2012 and 2018, patients aged ≥ 65 years with newly diagnosed glioblastoma were included in this retrospective analysis. Patients frailty was analyzed using the modified frailty index (mFI), while patients comorbidity burden was assessed according to the Charlson comorbidity index (CCI). Body mass index (BMI) was used as categorized variable.

Results
A total of 110 geriatric patients with newly diagnosed glioblastoma were identified. Geriatric patients categorized as least-frail achieved a median overall survival (mOS) of 17 months, whereas most frail patients achieved a mOS of 8 months (p = 0.003). Patients with a CCI > 2 had a lower mOS of 6 months compared to patients with a lower comorbidity burden (12 months; p = 0.03). Multivariate analysis identified “subtotal resection” (p = 0.02), “unmethylated MGMT promoter status” (p = 0.03), “BMI < 30” (p = 0.04), and “frail patient (mFI ≥ 0.27)” (p = 0.03) as significant and independent predictors of 1-year mortality in geriatric patients with surgical treatment of glioblastoma (Nagelkerke's R2 0.31).

Conclusions
The present study concludes that both increased frailty and comorbidity burden are significantly associated with poor OS in geriatric patients with glioblastoma. Further, the present series suggests an obesity paradox in geriatric glioblastoma patients.
Medicines use review service in community pharmacies in Spain: REVISA project
Authors: García-Agua Soler Nuria , Gómez-Bermúdez Eugenia , Baixauli-Fernández Vicente J. , Bellver-Beltrán Sara , Velasco-Martínez Javier , García Ruiz Antonio J. , Jódar-Sánchez Francisco 
Published: September 2020

AbstractBackground Community pharmacy services play an important role in controlling some factors related to medicine use and patients can benefit from these services to improve the adherence and knowledge of their medications, besides to reduce medicine-related problems. Objective The aim of the REVISA project is to carry out a study on preliminary implementation of the medicines use review service in Spanish community pharmacies. Setting Sixty-four community pharmacies from all regions of Spain. Method A preliminary implementation, cross-sectional multicentre study was conducted using a convenience sample of voluntary community pharmacies. A structured interview enabled to pharmacists to obtain a better understanding of patient’s medicines use. Main outcome measure Medicines use review-related time and cost, satisfaction and willingness to pay. Results A total of 495 patients were enrolled. The mean age of the patients was 66.1 years, with the majority females (56.4%) and a mean consumption of 5.7 medicines. A total of 2811 medicines were evaluated and 550 referral recommendations were made (29.8% to Primary Care). The mean time employed by the pharmacists in the medicines use review service was 52.8 min (medicines use review-related cost of €17.27). Most patients expressed a high level of satisfaction with this service (98.5%) and a willingness to pay for it (84%). Conclusion Medicines use review service in community pharmacies in Spain can be delivered, that it appears to be acceptable to patients and that most patients said they would be willing to pay for it. This service may offer an opportunity to promote inter-professional collaboration between pharmacists and general practitioners.
Association of Clinical Assessments of Hand Function and Quantitative Ultrasound Metrics in First Carpometacarpal Osteoarthritis
Authors: Nwawka O. Kenechi , Weinstock-Zlotnick Gwen , Lin Bin , Ko Lydia M. 
Published: September 2020

Background Thumb carpometacarpal (CMC) osteoarthritis (OA), a degenerative condition affecting hand use, is typically evaluated through radiographs and clinical examination. Although this can determine treatment, it is difficult to evaluate functional limitations. Shear wave elastography (SWE) is a quantitative ultrasound technique that characterizes tissue stiffness. Questions/Purposes This pilot study aimed to establish data of the SWE findings in the thenar eminence muscles in patients with first CMC OA and correlate these findings with the clinical tests of hand function. Methods This cross-sectional study correlated the SWE stiffness of thenar eminence muscles to clinical tests of hand function in patients with first CMC OA and in asymptomatic control subjects, using Spearman's correlation coefficient. Mean SWE values of the thenar eminence muscles in patients were compared with those in control subjects. The study was performed in a non-profit tertiary care hospital setting. Patients and control subjects were recruited on a volunteer basis. Results SWE values in the abductor pollicis brevis and flexor pollicis brevis muscles showed moderate to very strong correlation with multiple measures of hand function. Mean SWE values of the thenar eminence muscles in first CMC OA patients were lower than those in asymptomatic control subjects. Conclusions Correlations between mean SWE values in the thenar eminence muscles and clinical measures of hand function suggest decreased function in subjects with less stiff thenar eminence muscles.
Abnormal brain activity patterns during spatial working memory task in patients with end-stage renal disease on maintenance hemodialysis: a fMRI study
Authors: Huang Jinzhuang , Xie Lei , Guo Ruiwei , Wang Jinhong , Lin Jinquan , Sun Zongbo , Duan Shouxing , Lin Zhirong , Li Hui , Ma Shuhua 
Published: September 2020

AbstractHemodialysis (HD) is associated with cognitive impairment in patients with end-stage renal disease (ESRD). However, the neural mechanism of spatial working memory (SWM) impairment in HD-ESRD patients remains unclear. We investigated the abnormal alterations in SWM-associated brain activity patterns in HD-ESRD patients using blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) technique during n-back tasks. Twenty-two HD-ESRD patients and 22 well-matched controls underwent an fMRI scan while undergoing a three-load n-back tasks with different difficulty levels. Cognitive and mental states were assessed using a battery of neuropsychologic tests. The HD-ESRD patients exhibited worse memory abilities than controls. Compared with the control group, the HD-ESRD patient group showed lower accuracy and longer response time under the n-back tasks, especially in the 2-back task. The patterns of brain activation changed under different working memory loads in the HD-ESRD patients, showing decreased activity in the right medial frontal gyrus and inferior frontal gyrus under 0-back and 1-back task, while more decreased activation in the bilateral frontal cortex, parietal lobule, anterior/posterior cingulate cortex and insula cortex under 2-back task. With the increase of task difficulty, the activation degree of the frontal and parietal cortex decreased. More importantly, we found that lower activation in frontal cortex and parietal lobule was associated with worse cognitive function in the HD-ESRD patients. These results demonstrate that the abnormal brain activity patterns of frontal cortex and parietal lobule may reflect the neural mediation of SWM impairment.
Social and competitive threat as situational factors moderating relationships between moral judgments and different components of authoritarian ideology
Authors: Radkiewicz Piotr 
Published: September 2020

AbstractThis paper presents research on the complexity of moral judgments underlying two components of authoritarian ideology: right-wing authoritarianism (RWA) and social dominance orientation (SDO). Based on previous research, it was expected that people who were high on moral intuitions of Ingroup/loyalty and Authority/respect (Ethics of Community) should be high on RWA, whereas people who were high on moral intuitions of Care/harm and Fairness/reciprocity (Ethics of Autonomy) should be low on SDO. In more detailed hypotheses it was assumed that such general relationships would be moderated by situational factors - threat to social order and competitive threat, respectively. Two experimental studies were conducted: the first with manipulation of the threat to social order, and the second with manipulation of the competitive threat (N = 180 and 150, respectively). Both studies showed that Ethics of Community predicted clear increase in RWA, while the Ethics of Autonomy predicted considerable decrease in SDO. However positive relationships between Ingroup/loyalty and RWA as well as between Authority/respect and RWA were strongly reinforced by threat to social order, whereas the negative relationships between Care/harm and SDO as well as between Fairness/reciprocity and SDO diminished under situationally induced aggressive ‘Darwinian’ competition. The Ethics of Community appears as a moral basis for development of right-wing authoritarianism, and this relationship is especially strong when the social order is perceived as threatened. On the other hand, the Ethics of Autonomy can be seen as a moral basis for inhibition of social dominance orientation, but it loses the moral relevance in strongly competitive social environment.
Walking in My Shoes: Imagined Synchrony Improves Attitudes Towards Out-groups
Authors: Atherton Gray , Cross Liam 
Published: September 2020

AbstractPeople are prone to dividing others into the categories of ‘us’ and ‘them’. This can be particularly detrimental to minorities who may experience social exclusion, prejudice, and reduced access to equal opportunities. One method of improving intergroup relations is to create opportunities for contact. Common contact interventions have members of different groups meet and engage in conversation. There are also non-verbal embodied intergroup activities that produce the same effects. Previous work has shown that the pro-social effects of coordination may be linked to whether co-actors are classed as in or out-group members. The current study explored whether imagining walking in synchrony with in- or out-group members changed majority members’ attitudes towards those individuals. Imagining walking in synchrony fostered greater increases in empathy and decreases in negative attitudes only towards minority group members following imagined coordination (not in-groups). Implications and future directions are discussed.
Fibre optic sensing of ageing railway infrastructure enhanced with statistical shape analysis
Authors: Alexakis Haris , Lau F. Din-Houn , DeJong Matthew J. 
Published: September 2020

AbstractDeveloping early-warning sensor-based maintenance systems for ageing railway infrastructure, such as masonry arch bridges, can be a challenging task due to the difficulty of identifying degradation/damage as the source of small, gradual changes in sensor data, as opposed to other environmental and loading effects. This paper offers a new method of applying statistical modelling and machine learning to enhance the interpretation of fibre optic sensing data, and, therefore, improve deterioration monitoring of railway infrastructure. Dynamic strain and temperature monitoring data between 2016 and 2019 from a fibre Bragg grating (FBG) network installed in a Victorian railway viaduct are first presented. The statistical shape analysis adopted in this study is modified to track changes in the shape of FBG signals directly linked to train speed and dynamic strain amplitudes. The method is complemented by a support vector machine, which is trained to identify different classes of trains. After distinguishing train types, dynamic strain was found to be clearly correlated to temperature, verifying previous findings. No correlation with train speed was observed. The integrated system is then able to compensate for changes in the structural performance due to variations in train loading and ambient temperature, and identify changes in dynamic deformation caused by degradation, in an order comparable to the signal noise (± 2 micro-strain). As a result, the new procedure is shown to be capable of detecting small magnitudes of local degradation well before this degradation manifests itself in typical global measures of response.
The application of deep learning for the classification of correct and incorrect SNP genotypes from whole-genome DNA sequencing pipelines
Authors: Kotlarz Krzysztof , Mielczarek Magda , Suchocki Tomasz , Czech Bartosz , Guldbrandtsen Bernt , Szyda Joanna 
Published: September 2020

AbstractA downside of next-generation sequencing technology is the high technical error rate. We built a tool, which uses array-based genotype information to classify next-generation sequencing–based SNPs into the correct and the incorrect calls. The deep learning algorithms were implemented via Keras. Several algorithms were tested: (i) the basic, naïve algorithm, (ii) the naïve algorithm modified by pre-imposing different weights on incorrect and correct SNP class in calculating the loss metric and (iii)–(v) the naïve algorithm modified by random re-sampling (with replacement) of the incorrect SNPs to match 30%/60%/100% of the number of correct SNPs. The training data set was composed of data from three bulls and consisted of 2,227,995 correct (97.94%) and 46,920 incorrect SNPs, while the validation data set consisted of data from one bull with 749,506 correct (98.05%) and 14,908 incorrect SNPs. The results showed that for a rare event classification problem, like incorrect SNP detection in NGS data, the most parsimonious naïve model and a model with the weighting of SNP classes provided the best results for the classification of the validation data set. Both classified 19% of truly incorrect SNPs as incorrect and 99% of truly correct SNPs as correct and resulted in the F1 score of 0.21 — the highest among the compared algorithms. We conclude the basic models were less adapted to the specificity of a training data set and thus resulted in better classification of the independent, validation data set, than the other tested models.
Beyond VoF: alternative OpenFOAM solvers for numerical wave tanks
Authors: Schmitt Pál , Windt Christian , Davidson Josh , Ringwood John V. , Whittaker Trevor 
Published: September 2020

AbstractThe vast majority of numerical wave tank applications are solved using finite volume-based, volume of fluid methods. One popular numerical modelling framework is OpenFOAM and its two phase solvers, interFoam and interIsoFoam, enabling the simulation of a broad range of marine hydrodynamic phenomena. However, in many applications, certain aspects of the entire set of possible hydrodynamic phenomena are not of interest and the reduced complexity could allow the use of simpler, more computationally efficient solvers. One barrier for the application of such alternative solvers is the lack of suitable wavemaking and absorption capabilities, which this paper aims to address. A wavemaking and absorption methodology is presented, which can be applied to different solvers using the same fundamental concept. The implementation is presented for interFoam and interIsoFoam, as well as two other solvers whose use as numerical wave tanks has not previously been reported in the literature, shallowWaterFoam and potentialFreeSurfaceFoam. Parameter studies are performed to guide the user in the use of the methods. Example applications for two industrially relevant test cases are demonstrated; a multi-frequency wave packet focused at one position over flat bottom and regular waves propagating over a submerged shoal. All solvers yielded useful results, but some complex wave transformations in the shoal case were only resolved by the VoF methods. Alternative methods beyond the already well established VoF methods seem worth considering because potential for significant reductions in computational effort exist.
Autonomous dry stone
Authors: Johns Ryan Luke , Wermelinger Martin , Mascaro Ruben , Jud Dominic , Gramazio Fabio , Kohler Matthias , Chli Margarita , Hutter Marco 
Published: September 2020

AbstractOn-site robotic construction not only has the potential to enable architectural assemblies that exceed the size and complexity practical with laboratory-based prefabrication methods, but also offers the opportunity to leverage context-specific, locally sourced materials that are inexpensive, abundant, and low in embodied energy. We introduce a process for constructing dry stone walls in situ, facilitated by a customized autonomous hydraulic excavator. Cabin-mounted LiDAR sensors provide for terrain mapping, stone localization and digitization, and a planning algorithm determines the placement position of each stone. As the properties of the materials are unknown at the beginning of construction, and because error propagation can hinder the efficacy of pre-planned assemblies with non-uniform components, the structure is planned on-the-fly: the desired position of each stone is computed immediately before it is placed, and any settling or unexpected deviations are accounted for. We present the first result of this geometric- and motion-planning process: a 3-m-tall wall composed of 40 stones with an average weight of 760 kg.
Insubordinate Plasticity: Judith Butler and Catherine Malabou
Authors: Helberg Natalie 
Published: September 2020

AbstractIn this article, I explore the relationship betweenperformativity, as it appears in Judith Butler's work, andplasticity, as it appears in the work of Catherine Malabou. I argue that these concepts are isomorphic. Butler and Malabou both hold that resistance to contemporary forms of power, or “insubordination,” is contingent on a subject's ability to become other than what it is; Butler articulates this ability in terms of performativity, and Malabou articulates it in terms of plasticity. I reveal the social-constructivist dimension of Malabou's work while also making apparent the extent to which Butler's work, contrary to her own way of conceptualizing it, and hence surprisingly and uneasily, presupposes a biologically basic capacity for change. Plasticity is this biologically basic capacity. Both thinkers affirm the idea that insubordinate forms of transformation can be impeded by the discourse that conditions what a subject can think. I suggest that this is an insight that must be heeded, even as I seek to affirm a form of plasticity beyond discourse.
A Nation on Paper: Making a State in the Republic of Biafra
Authors: Daly Samuel Fury Childs 
Published: September 2020

AbstractWhat role did law play in articulating sovereignty and citizenship in postcolonial Africa? Using legal records from the secessionist Republic of Biafra, this article analyzes the relationship between law and national identity in an extreme context—that of the Nigerian Civil War (1967–1970). Ideas about order, discipline, and legal process were at the heart of Biafra's sense of itself as a nation, and they served as the rhetorical justification for its secession from Nigeria. But they were not only rhetoric. In the turmoil of the ensuing civil war, Biafra's courts became the center of its national culture, and law became its most important administrative implement. In court, Biafrans argued over what behaviors were permissible in wartime, and judges used law to draw the boundaries of the new country's national identity. That law played this role in Biafra shows something broader about African politics: law, bureaucracy, and paperwork meant more to state-making than declensionist views of postcolonial Africa usually allow. Biafra failed as a political project, but it has important implications for the study of law in postcolonial Africa, and for the nation-state form in general.
Nationalist Spirits of Islamic Law after World War I: An Arab-Indian Battle of Fatwas over Alcohol, Purity, and Power
Authors: Halevi Leor 
Published: September 2020

AbstractIn 1922, one of the most famous Muslim scholars of modern times, the Syrian-Egyptian reformer Rashīd Riḍā, published in his journal a detailed fatwa in defense of alcohol. He did so in reaction to an obscure Indian jurist's fatwa that had warned Muslims not to use alcoholic products. On the surface, the authors of the fatwas appeared to be principally concerned with the right way to interpret sacred laws of purity and pollution. However, this article reveals that their disagreement had much to do with differing approaches to the politics of independence. Their divergence is intriguing because the cities where they lived, Cairo and Bombay, had just experienced the convulsions of anti-British consumer boycotts. And it emerged at a time when anti-imperial Muslim activists from the Middle East and South Asia were rallying together for a pan-Islamic cause—to prevent the final collapse of the caliphate. These movements swayed both Riḍā and his rival, who may well be described as Muslim nationalists. Yet they embraced radically different strategies for independence. One aimed for national purity, the other for national power. This discrepancy led to the battle of fatwas—a forgotten battle that is worth remembering because it suggests some of the difficulties that Muslim jurists of Arab or Indian ancestry faced during the interwar period when they tried to turn Islamic law into an effective nationalist discourse.
Physics basis for the ICRF system of the SPARC tokamak
Authors: Lin Y. , Wright J. C. , Wukitch S. J. 
Published: September 2020

Ion cyclotron range of frequencies (ICRF) heating will be the sole auxiliary heating method on SPARC for both full-field (Bt0 ~ 12 T) D–T operation and reduced field (Bt0 ~ 8 T) D–D operation. Using the fast wave at ~120 MHz, good wave penetration and strong single-pass absorption is expected for D–T(3He), D(3He), D(H) and4He(H) heating scenarios. The dependences of wave absorption on${k_\parallel }$,3He concentration, resonance location, antenna poloidal location and losses on alpha particles and ash have been studied. The antenna loading has been assessed by comparison with the Alcator C-Mod antennae. An antenna spectrum of${k_\parallel }\sim 15\text{--}18\,{\textrm{m}^{ - 1}}$is shown to be good for both core absorption and edge coupling. For the control of impurity sources, the antenna straps are rotated ~10° to be perpendicular to the B field and the straps can run with different power levels in order to optimize the antenna spectrum and to minimize the image current on the antenna frame. Combining the physics constraints with the SPARC port design, maintenance requirement and contingency against antenna failure during D–T operation, we plan to mount on the inner wall of the vacuum vessel a total of 12 4-strap antennae in 6 ports while keeping 3-strap antennae that are insertable and removable on port plugs as the backup option.