bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimations of Typical, Ideal, Premature Ejaculation, and Actual Latencies by Men and Female Sexual Partners of Men During Partnered Sex
Authors: Côté-Léger Philippe , Rowland David L. 
Published: June 2020

Abstract

Background
The ejaculation latency (ELT) criterion for men with premature ejaculation (PE), including its 2 major subtypes of lifelong and acquired, relies heavily on expert opinion, yet such information represents only one source of data for this determination; furthermore, information regarding ELTs for PE within specific subgroups of men (eg, gay, bisexual) has been lacking.

Aim
To obtain data regarding men's lived experiences and expectations regarding typical ejaculation, ideal ejaculation, and PE and (for men) self-reported ejaculatory latencies during partnered sex across a variety a groups, including men vs women (ie, sexual partners of men), men with and without PE, and straight vs gay/bisexual men.

Methods
We recruited 1,065 men and sexual partners of men, asking them to estimate typical ejaculation, ideal ejaculation, and PE and (for men) self-latencies through an online survey posted on social media. Demographics, sexual identity, and sexual response data were also collected.

Results
Typical and self-reported ELTs were closely aligned with those reported in the literature, with ideal ELTs generally longer than typical ELTs. Median PE ELTs were consistently estimated around 1.5 min, with nearly all subgroups—men vs women; straight vs gay; PE and non-PE men—showing alignment on this criterion. Men with lifelong PE did not differ from men with acquired PE in either their PE ELT estimation or their self-reported ELT.

Clinical Implications
The data support the idea of extending the latency cutoff for establishing a PE diagnosis beyond the current 1-minute threshold.

Strengths & Limitations
A large sample size drawn from a multinational population powered the study, whereas the use of social media for recruitment and lack of inclusion of lesbian and asexual individuals may have missed relevant data from some who have had sexual experience with men.

Conclusion
Straight and nonstraight men do not differ in their ELT estimations. In addition, the use of different ELT criteria for lifelong vs acquired PE may be unnecessary.
Research software in cochlear duct length estimation, Greenwood frequency mapping and CI electrode array length simulation
Authors: Dhanasingh Anandhan 
Published: June 2020

Background and objectiveThe size of the cochlea varies a lot among the human population bringing the necessity for electrode arrays to be available in various lengths irrespective of the cochlear implant (CI) brand. This research software helps in the estimation of the patient's cochlear duct length (CDL) which is then used for the simulation of the correct length electrode array matching the patient's cochlear size and as well in getting the patient specific cochlear frequency map.MethodsVisual Studio Express 2012 for Windows Desktop is used in the architecture of this research software. The basal turn diameter of the cochlea (“A” value) needs to be measured from the pre‐operative computed tomography (CT) image of the patient's temporal bone. This “A” will be taken as the input for the CDL equations proposed by Alexiades et al for estimating the CDL along the basilar membrane for various insertion depths. Greenwood's equation is then used in combination with the CDL for the full length of the cochlea in getting the patient specific frequency map.ResultsThe research software with the help of the “A” value as input, with few button clicks, gives the patient specific CDL for various insertion depths and the Greenwood's frequency map. The users have the choice to select any electrode array of their choice and place it under the frequency map to see how good it fits to that particular patient's cochlea. Also, given the possibility to drag and move the electrode array picture to mimic the post‐operative actual electrode insertion depth.ConclusionsThis research software simplifies the overall process of CDL estimation and in getting the patient specific cochlear frequency map. The clinicians get the chance to simulate placing the various electrode array lengths in patient cochlea in identifying the best fit electrode. This could help in pushing the CI field into the concept of individualized CI electrode array solution that ultimately benefits the patients.
A METHOD FOR CONSTRUCTING AND INTERPRETING SOME WEIGHTED PREMIUM PRINCIPLES
Authors: Castaño-Martínez Antonia , López-Blazquez Fernando , Pigueiras Gema , Sordo Miguel Á. 
Published: June 2020

AbstractWe present a method for constructing and interpreting weighted premium principles. The method is based on modifying the underlying risk distribution in such a way that the risk-adjusted expected value (or premium) is greater than the expected value of some conveniently chosen function of claims, which defines the insurer’s perception of the risk. Under some assumptions on the function of claims, the method produces distortion premium principles. We provide several examples under different assumptions on the claim arrival process and different functions of claims, including record claims andkth record claims.
Nietzsche's ‘Eternal Recurrence’ and the renaissance of English and Welsh insolvency law reform
Authors: Tribe John 
Published: June 2020

AbstractFriedrich Nietzsche proposed the ‘Eternal Recurrence’ thought experiment in his book,The Gay Science(1882). Drawing on ancient Greek and Indian philosophy, Eternal Recurrence is the idea that with infinite time and matter events will occur again and again without end. While not (quite) infinite, English and Welsh insolvency law does have a sufficient and significant history that reveals numerous examples of this phenomenon of repetition. This paper examines some of the patterns of repetition within the law and reform processes and how ‘broad’, ‘narrow’, and ‘deep’ Eternal Recurrence applies to English and Welsh insolvency law. Three examples of Eternal Recurrence are examined: (1) the plight of the unsecured creditor; (2) the quest for protection, including the use of security devices; and (3) the accountability of directors in corporate insolvency, with specific reference to human rights protection for directors versus insolvency law objectives for the benefit of creditors. Finally, suggestions are provided as to why ‘insolvency’ Eternal Recurrence is problematic, particularly for law reform development and the reform of insolvency law in England and Wales.
The Parkes Pulsar Timing Array project: second data release
Authors: Kerr Matthew , Reardon Daniel J. , Hobbs George , Shannon Ryan M. , Manchester Richard N. , Dai Shi , Russell Christopher J. , Zhang Songbo , van Straten Willem , Osłowski Stefan , Parthasarathy Aditya , Spiewak Renee , Bailes Matthew , Bhat N. D. Ramesh , Cameron Andrew D. , Coles William A. , Dempsey James , Deng Xinping , Goncharov Boris , Kaczmarek Jane F. , Keith Michael J. , Lasky Paul D. , Lower Marcus E. , Preisig Brett , Sarkissian John Mihran , Toomey Lawrence , Wang Hongguang , Wang Jingbo , Zhang Lei , Zhu Xingjiang 
Published: June 2020

AbstractWe describe 14 yr of public data from the Parkes Pulsar Timing Array (PPTA), an ongoing project that is producing precise measurements of pulse times of arrival from 26 millisecond pulsars using the 64-m Parkes radio telescope with a cadence of approximately 3 weeks in three observing bands. A comprehensive description of the pulsar observing systems employed at the telescope since 2004 is provided, including the calibration methodology and an analysis of the stability of system components. We attempt to provide full accounting of the reduction from the raw measured Stokes parameters to pulse times of arrival to aid third parties in reproducing our results. This conversion is encapsulated in a processing pipeline designed to track provenance. Our data products include pulse times of arrival for each of the pulsars along with an initial set of pulsar parameters and noise models. The calibrated pulse profiles and timing template profiles are also available. These data represent almost 21 000 h of recorded data spanning over 14 yr. After accounting for processes that induce time-correlated noise, 22 of the pulsars have weighted root-mean-square timing residuals of$<\!\!1\,\mu\text{s}$in at least one radio band. The data should allow end users to quickly undertake their own gravitational wave analyses, for example, without having to understand the intricacies of pulsar polarisation calibration or attain a mastery of radio frequency interference mitigation as is required when analysing raw data files.
The impact of genetic polymorphisms on weight regain after successful weight loss
Authors: Thonusin Chanisa , Shinlapawittayatorn Krekwit , Chattipakorn Siriporn C. , Chattipakorn Nipon 
Published: June 2020

AbstractObesity is associated with an increased risk of various diseases and mortality. Although nearly 50 % of adults have been reported trying to lose weight, the prevalence of obesity has increased. One factor that hinders weight loss-induced decrease in obesity prevalence is weight regain. Although behavioural, psychological and physiological factors associated with weight regain have been reviewed, the information regarding the relationship between weight regain and genetics has not been previously summarised. In this paper, we comprehensively review the association between genetic polymorphisms and weight regain in adults and children with obesity after weight loss. Based on this information, identification of genetic polymorphism in patients who undergo weight loss intervention might be used to estimate their risks of weight regain. Additionally, the genetic-based risk estimation may be used as a guide for physicians and dietitians to provide each of their patients with the most appropriate strategies for weight loss and weight maintenance.
EXPLORING THE VERIDICALITY AND REACTIVITY OF SUBJECTIVE MEASURES OF AWARENESS
Authors: Sachs Rebecca , Hamrick Phillip , McCormick Timothy J. , Leow Ronald P. 
Published: June 2020

AbstractSubjective measures (SMs) of awareness assume (a) participants can accurately report the implicit/explicit status of their knowledge and (b) the act of reporting does not change that knowledge. However, SMs suffer from nonveridicality (e.g., overreporting of “guess” responses) and reactivity (e.g., prompting rule search). Attempting to improve the validity of “guess” responses, we conducted an exploratory mixed-methods replication of Rebuschat et al. (2013). Participants (N = 30) were randomly assigned to Traditional, True Guess, and NoSMs conditions. True Guess participants were led to believe the computer would replace “guess” responses with random answers. Confirming that SMs are reactive, Traditional and True Guess participants responded more slowly and accurately, with greater awareness of the linguistic target. Moreover, although True Guess participants responded “guess” less frequently, interviews revealed this was due not to greater veridicality, but rather to additional reactivity. We conclude with directions for further research to enhance the validity of SMs.
Drug Repurposing for COVID-19: Ethical Considerations and Roadmaps
Authors: INO HIROYASU , NAKAZAWA EISUKE , AKABAYASHI AKIRA 
Published: June 2020

AbstractWhile the world rushed to develop treatments for COVID-19, some turned hopefully to drug repurposing (drug repositioning). However, little study has addressed issues of drug repurposing in emergency situations from a broader perspective, taking into account the social and ethical ramifications. When drug repurposing is employed in emergency situations, the fairness of resource distribution becomes an issue that requires careful ethical consideration.This paper examines the drug repurposing in emergency situations focusing on the fairness using Japanese cases. Ethical issues under these circumstances addressed by the authors include: maintaining the evidence level, integrity of clinical research ethics, and voluntary consent by original indication patients. In order to address these issues, they argue that rapid accumulation of ethically and scientifically valid evidence is required, as is obtaining information on resource quantity.
Idiopathic dilatation of the right atrium: a not so benign entity
Authors: Walter Carin , Bartrons Joaquim , Gómez Olga , Caffarena José M. , Carretero Juan M. 
Published: June 2020

AbstractIdiopathic dilatation of the right atrium is an isolated enlargement of the right atrium in the absence of other cardiac lesions. This rare anomaly has a clinical spectrum ranging from asymptomatic to heart failure or even sudden death. It can be associated with atrial arrhythmias and thrombus formation. Antiplatelet therapy is prescribed in most cases reported in the literature, and reduction plasty is indicated when there is rapid growth of the right atrium, compression of adjacent structures, or refractory arrhythmias. We report four cases of idiopathic dilatation of the right atrium diagnosed during prenatal screening. We describe the intrauterine course and management in postnatal life until early childhood.
Recurrent infective endocarditis in a patient after a second Melody valve placement
Authors: Takajo Daiji , Forbes Thomas J. , Aggarwal Sanjeev 
Published: June 2020

AbstractA 16-year-old Caucasian male was diagnosed with recurrent infective endocarditis associated with his second Melody valve placed inside a previously treated infected Melody valve. The replacement of Melody valve after the first infective endocarditis episode might increase the risk of the second episode of infective endocarditis.
What do ‘lay’ people know about justice? An empirical enquiry
Authors: Irvine Charlie 
Published: June 2020

AbstractWhen mediation places decision-making power in the hands of lay disputants it raises troubling issues. Can justice be delivered without judicial assistance? What is the effect on the legal system? And how should outcomes thus achieved be regarded? Critics have tended to answer negatively, pointing to a range of harms including individual oppression and the vanishing trial. Such views, focusing too narrowly on conformity to legal norms, overlook ordinary people's capacity for justice reasoning. A recent Scottish pilot study of small-claims mediation parties illustrates the richness and complexity of their thinking around whether, and for how much, to settle. This suggests that mediation settlements, rather than representing second-class justice, may enhance the legitimacy of the legal system. Implications for theories of justice are considered.
Estimation of Daily Rainfall Extremes Through the Metastatistical Extreme Value Distribution: Uncertainty Minimization and Implications for Trend Detection
Authors: Miniussi Arianna , Marani Marco 
Published: June 2020

AbstractThe accurate estimation of hydrologic extremes is central to planning and engineering mitigation and adaptation measures. The traditional extreme value theory is based on often overlooked assumptions that preclude the use of all available observations and negatively affect estimation uncertainty. The Metastatistical Extreme Value Distribution (MEVD) was introduced to make full use of available data and was shown to significantly improve estimation uncertainty for large extremes. However, no systematic understanding existed as to how to optimally apply the MEVD depending on the statistical properties of the observed variables. With reference to daily rainfall, we identify here the local climatic factors that define the optimal MEVD formulation. We analyze a large set of long daily rainfall records, as well as synthetic time series with prescribed statistical characteristics, and find that (1) in most climates the MEVD should be based on yearly estimates of the ordinary rainfall distributions, and only in climates with less than20–25 year the estimation of distributional/year the estimation of distributional parameters requires samples longer than 1 year; (2) the interannual variability in the distributions of rainfall should be explicitly resolved when20–25 rainy days/year. Finally, we use the optimized MEVD to study the variability of daily rainfall extremes over 294 years in Padova (Italy) and compare it to traditional extreme value estimates. We find that, through its improved accuracy for short observations, MEVD better resolves high‐quantile fluctuations and allows the emergence of long‐term trends over estimation noise.
A Laboratory Study of the Effect of Surface Waves on Heat and Momentum Transfer at High Wind Speeds
Authors: Troitskaya Yuliya , Sergeev Daniil , Vdovin Maksim , Kandaurov Alexander , Ermakova Olga , Takagaki Naohisa 
Published: June 2020

AbstractThis paper describes laboratory experiments (using a high‐speed wind‐wave flume) of the effects of water waves on heat and momentum exchange in the near‐water atmospheric boundary layer at high wind speeds. Different from previous experiments of this type, the parameters of waves were controlled by a net stretched along the entire channel to effectively decrease the fetch. This helped to achieve dependency of the transfer coefficients on two independent parameters, namely, the wind speed and fetch (expressed via variations of the wavefield). Another key to the experiment was using a stable temperature stratification of the air flow, with the temperature of the air entering the flume 15–25° higher than the water. The experiments showed a sharp increase in the heat exchange coefficient at winds exceeding 33–35 m/s, similar to that observed earlier in the high‐speed wind‐wave flume of Kyoto University with conditions of unstable temperature stratification of the air flow. The joint analysis of the data obtained in the high‐speed wind‐wave flumes of IAP RAS and Kyoto University yields the universal dependency of the exchange coefficients and the temperature roughness on the peak wave number of surface wave spectra. This is independent of the type of temperature stratification of the atmospheric boundary layer, either stable or unstable. The sharp increase in the heat exchange coefficient is shown to be associated with increased whitecapping.
Severe cardiac involvement with preserved truncated dystrophin expression in Becker muscular dystrophy by +1G>A DMD splice-site mutation: a case report
Authors: Komaki Ryouhei , Hashimoto Yasumasa , Mori-Yoshimura Madoka , Oya Yasushi , Takizawa Hotake , Minami Narihiro , Nishino Ichizo , Aoki Yoshitsugu , Takahashi Yuji 
Published: June 2020

AbstractBecker muscular dystrophy (BMD) is caused by specific mutations in the DMD gene that causes progressive muscle weakness and primarily affects skeletal and cardiac muscle. Although cardiac involvement is a significant cause of mortality in BMD, the genetic–phenotype correlation for skeletal and cardiac muscles has not been elucidated. Here, we described a 39-year-old man with BMD, who presented with subtle skeletal muscle weakness in the right leg in his 20s and underwent left ventricular restoration for severe dilated cardiomyopathy at the age of 29. He had difficulty climbing stairs after the age of 35. Neither duplication nor deletion of exons was detected by multiplex ligation-dependent probe amplification. A hemizygous c.264 + 1G>A mutation in intron 4 of the DMD was identified by next-generation sequencing. Furthermore, exon 4 skipping of the DMD was confirmed in both skeletal and cardiac muscles evaluated by reverse transcriptase PCR. Endomyocardial and skeletal muscle biopsies revealed dystrophic pathology characterized by muscle fiber atrophy and hypertrophy with a mild degree of interstitial fibrosis. Interestingly, dystrophin immunohistochemistry demonstrated patchy and faint staining of the skeletal muscle membranes but almost normal staining of the cardiac muscle membranes. Western blot analysis revealed a decreased amount of truncated dystrophin in skeletal muscle but surprisingly almost normal amount in cardiac muscle. This case indicates that BMD patients may have severe cardiac dysfunction despite preserved cardiac truncated dystrophin expression.
Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles
Authors: Wang Daning , Liu Xinlin , Wei Minxi , Qian Ciying , Song Shuo , Chen Jie , Wang Zhiping , Xu Qin , Yang Yurou , He Maozhou , Chi Xin , Huang Shiwen , Li Tingting , Kong Zhibo , Zheng Qingbing , Yu Hai , Wang Yingbin , Zhao Qinjian , Zhang Jun , Xia Ningshao , Gu Ying , Li Shaowei 
Published: June 2020

AbstractThe capsid of human papillomavirus (HPV) spontaneously arranges into a T = 7 icosahedral particle with 72 L1 pentameric capsomeres associating via disulfide bonds between Cys175 and Cys428. Here, we design a capsomere-hybrid virus-like particle (chVLP) to accommodate multiple types of L1 pentamers by the reciprocal assembly of single C175A and C428A L1 mutants, either of which alone encumbers L1 pentamer particle self-assembly. We show that co-assembly between any pair of C175A and C428A mutants across at least nine HPV genotypes occurs at a preferred equal molar stoichiometry, irrespective of the type or number of L1 sequences. A nine-valent chVLP vaccine—formed through the structural clustering of HPV epitopes—confers neutralization titers that are comparable with that of Gardasil 9 and elicits minor cross-neutralizing antibodies against some heterologous HPV types. These findings may pave the way for a new vaccine design that targets multiple pathogenic variants or cancer cells bearing diverse neoantigens.
Nanocasting SiO2 into metal–organic frameworks imparts dual protection to high-loading Fe single-atom electrocatalysts
Authors: Jiao Long , Zhang Rui , Wan Gang , Yang Weijie , Wan Xin , Zhou Hua , Shui Jianglan , Yu Shu-Hong , Jiang Hai-Long 
Published: June 2020

AbstractSingle-atom catalysts (SACs) have sparked broad interest recently while the low metal loading poses a big challenge for further applications. Herein, a dual protection strategy has been developed to give high-content SACs by nanocasting SiO2 into porphyrinic metal–organic frameworks (MOFs). The pyrolysis of SiO2@MOF composite affords single-atom Fe implanted N-doped porous carbon (FeSA–N–C) with high Fe loading (3.46 wt%). The spatial isolation of Fe atoms centered in porphyrin linkers of MOF sets the first protective barrier to inhibit the Fe agglomeration during pyrolysis. The SiO2 in MOF provides additional protection by creating thermally stable FeN4/SiO2 interfaces. Thanks to the high-density FeSA sites, FeSA–N–C demonstrates excellent oxygen reduction performance in both alkaline and acidic medias. Meanwhile, FeSA–N–C also exhibits encouraging performance in proton exchange membrane fuel cell, demonstrating great potential for practical application. More far-reaching, this work grants a general synthetic methodology toward high-content SACs (such as FeSA, CoSA, NiSA).
Aging increases vulnerability to stress-induced depression via upregulation of NADPH oxidase in mice
Authors: Lee Jung-Eun , Kwon Hye-Jin , Choi Juli , Seo Ji-Seon , Han Pyung-Lim 
Published: June 2020

AbstractBrain aging proceeds with cellular and molecular changes in the limbic system. Aging-dependent changes might affect emotion and stress coping, yet the underlying mechanisms remain unclear. Here, we show aged (18-month-old) mice exhibit upregulation of NADPH oxidase and oxidative stress in the hippocampus, which mirrors the changes in young (2-month-old) mice subjected to chronic stress. Aged mice that lack p47phox, a key subunit of NADPH oxidase, do not show increased oxidative stress. Aged mice exhibit depression-like behavior following weak stress that does not produce depressive behavior in young mice. Aged mice have reduced expression of the epigenetic factor SUV39H1 and its upstream regulator p-AMPK, and increased expression of Ppp2ca in the hippocampus—changes that occur in young mice exposed to chronic stress. SUV39H1 mediates stress- and aging-induced sustained upregulation of p47phox and oxidative stress. These results suggest that aging increases susceptibility to stress by upregulating NADPH oxidase in the hippocampus.