bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functionalization of hydroxyapatite derived from cockle (Anadara granosa) shells into hydroxyapatite–nano TiO2 for photocatalytic degradation of methyl violet
Authors: Fatimah Is , Fahrani Della , Harmawantika Tia , Sahroni Imam , Kamari Azlan , Sa’bana Rahmatillah Cecep , Nurillahi Rico 
Published: December 2019

AbstractPhotocatalyst of hydroxyapatite–nano TiO2 (HAp-nTiO2) was prepared from phosphatation of calcined cockle (Anadara granosa) shells followed by dispersion of nano TiO2 powder into HAp precipitate and calcination at 400 °C for 2 h. The prepared material was characterized using X-ray diffraction, scanning electron microscope–energy dispersive X-ray spectrophotometry, gas sorption analysis, and UV-Vis diffuse reflectance spectrophotometry. The photocatalytic activity of the material was evaluated for methyl violet degradation over photocatalysis and photooxidation mechanism. The results showed that the homogeneous dispersion of TiO2 in the HAp-nTiO2 composite was achieved, as seen in the X-ray diffraction analysis, diffuse reflectance UV-Vis, and gas sorption analyses. The physicochemical and photocatalytic character of the composite exhibited the positive role of HAp as TiO2 support in enhancing the photocatalytic activity with a higher turnover number and reusability property than that of pure TiO2. It was also noted that the HAp-nTiO2 composite demonstrated rapid methyl violet degradation over photooxidation rather than by photocatalytic mechanism.
Gemtuzumab Ozogamicin in NPM1-Mutated Acute Myeloid Leukemia: Early Results From the Prospective Randomized AMLSG 09-09 Phase III Study
Authors: Schlenk Richard F. , Paschka Peter , Krzykalla Julia , Weber Daniela , Kapp-Schwoerer Silke , Gaidzik Verena I. , Leis Claudia , Fiedler Walter , Kindler Thomas , Schroeder Thomas , Mayer Karin , Lübbert Michael , Wattad Mohammed , Götze Katharina , Horst Heinz A. , Koller Elisabeth , Wulf Gerald , Schleicher Jan , Bentz Martin , Greil Richard , Hertenstein Bernd , Krauter Jürgen , Martens Uwe , Nachbaur David , Abu Samra Maisun , Girschikofsky Michael , Basara Nadezda , Benner Axel , Thol Felicitas , Heuser Michael , Ganser Arnold , Döhner Konstanze , Döhner Hartmut 
Published: December 2019

PURPOSE High CD33 expression in acute myeloid leukemia (AML) with mutated NPM1 provides a rationale for the evaluation of gemtuzumab ozogamicin (GO) in this AML entity. We conducted a randomized trial to evaluate GO in combination with intensive induction and consolidation therapy in NPM1-mutated AML. PATIENTS AND METHODS Between May 2010 and September 2017, patients ≥ 18 years old and considered eligible for intensive therapy were randomly assigned up front for induction therapy with idarubicin, cytarabine, etoposide, and all- trans-retinoic acid with or without GO. The early ( P = .02) primary end point of event-free survival (EFS) was evaluated 6 months after completion of patient recruitment. RESULTS Five hundred eighty-eight patients were randomly assigned (standard arm, n = 296; GO arm, n = 292). EFS in the GO arm was not significantly different compared with that in the standard arm (hazard ratio, 0.83; 95% CI, 0.65 to 1.04; P = .10). The early death rate during induction therapy was 10.3% in the GO arm and 5.7% in the standard arm ( P = .05). Causes of death in both arms were mainly infections. The cumulative incidence of relapse (CIR) in patients achieving a complete remission (CR) or CR with incomplete hematologic recovery (CRi) was significantly reduced in the GO arm compared with the standard arm ( P = .005), with no difference in the cumulative incidence of death ( P = .80). Subgroup analysis revealed a significant beneficial effect of GO in female, younger (≤ 70 years), and FLT3 internal tandem duplication–negative patients with respect to EFS and CIR. CONCLUSION The trial did not meet its early primary end point of EFS, mainly as a result of a higher early death rate in the GO arm. However, in patients achieving CR/CRi after induction therapy, significantly fewer relapses occurred in the GO compared with the standard arm.
Commentary: Considerations in the Measurement of Glass Transition Temperatures of Pharmaceutical Amorphous Solids
Authors: Newman Ann , Zografi George 
Published: December 2019

AbstractAn increased interest in using amorphous solid forms in pharmaceutical applications to increase solubility, dissolution, and bioavailability has generated a need for better characterization of key properties, such as the glass transition (Tg) temperature. Although many laboratories measure and report this value, the details around these measurements are often vague or misunderstood. In this article, we attempt to highlight and compare various aspects of the two most common methods used to measure pharmaceutical Tg values, conventional and modulated differential scanning calorimetry (DSC). Issues that directly impact the Tg, such as instrumental parameters, sample preparation methods, data analysis, and “wet” vs. “dry” measurements, are discussed.
Simultaneous Occurrence of Germline Mutations of SDHB and TP53 in a Patient with Metastatic Pheochromocytoma
Authors: Gniado Ewa , Carracher Colin P , Sharma Sona 
Published: December 2019

Abstract

Context
We describe a patient with metastatic malignant pheochromocytoma who was found to have germline SDHB and TP53 mutations occurring together.

Case Description
A 39-year-old male presented with neck pain. Magnetic resonance imaging of the neck revealed a C3 vertebral body collapse and an underlying C3 lesion. Computed tomography (CT) of the thorax, abdomen, and pelvis showed multiple skeletal lesions, a sternal mass, bilateral pulmonary nodules, bilateral adrenal masses, and an aortocaval lymph node conglomerate. He underwent biopsy of the sternal mass, which revealed metastatic pheochromocytoma and subsequent blood work showed serum epinephrine levels of 200 pg/mL (normal 10–200 pg/mL), norepinephrine 28 241 pg/mL (normal 80–520 pg/mL), and dopamine 250 pg/mL (normal 0–20 pg/mL). Genetic testing revealed both SDHB and TP53 germline mutations. He was started on α- and β-blockers and calcium channel blockers to control hypertension and tachycardia. Two months after the diagnosis, a CT of the abdomen and pelvis showed progression of disease, with enlargement of the right adrenal mass as well as the aortocaval conglomeration. His plasma metanephrines were significantly elevated. He was started on systemic chemotherapy with cyclophosphamide, dacarbazine, and vincristine. He required several antihypertensive agents, including metyrosine, to control his blood pressure in preparation for chemotherapy.

Conclusion
This is the first reported case of simultaneous SDHB and TP53 germline mutations occurring in an individual with a highly aggressive clinical course of pheochromocytoma. We speculate that the simultaneous occurrence of these 2 oncogenic mutations may have led to an aggressive tumor progression.
Radical Interdisciplinarity
Authors: King Rosamond S. 
Published: December 2019

Abstract
This essay delineates the concept of radical interdisciplinarity, the use of methodologies that combine traditional scholarship with that which is not traditionally considered either scholarship or even part of an academic discipline—specifically poetry and other creative arts. The author describes radical interdisciplinarity as building on the hybrid methodologies of women of color authors such as Gloria Anzaldúa, Audre Lorde, Leslie Marmon Silko, and Michelle Cliff, who often combined memoir with fiction or poetry. The essay itself includes examples of radical interdisciplinarity in the form of a critical biomythography that weaves together scholarly analysis and poetry related to the author’s current research on the jamette women of nineteenth-century Trinidad.
Οι επιδράσεις του νέου δημόσιου μάνατζμεντ στην εκπαίδευση
Authors: Σταύρου Δημήτριος 
Published: December 2019

Το Νέο Δημόσιο Μάνατζμεντ χαρακτηρίζεται από τη φιλοσοφία της μεταρρύθμισης του δημόσιου τομέα προς την κατεύθυνση της αποκέντρωσης και της λειτουργίας με ιδιωτικοοικονομικά κριτήρια. Αν και οι εκπαιδευτικές πολιτικές που απορρέουν από το ΝΔΜ παρουσιάζουν κοινά χαρακτηριστικά σε όλο τον κόσμο, οι επιδράσεις τους μετριάζονται, μεταξύ άλλων παραγόντων, από την τοπική ιστορία, τις κοινωνικοπολιτικές και ιδεολογικές συνθήκες και την περίπλοκη αλληλεπίδραση των διεθνών και των τοπικών δυναμικών. Σημείο αιχμής για τις πολιτικές αυτές είναι η παιδαγωγική, διοικητική και οικονομική αυτονομία της σχολικής μονάδας, ενώ ο ρόλος των διευθυντών έχει επηρεαστεί σε πολύ σημαντικό βαθμό από τις παραπάνω εξελίξεις με αποτέλεσμα να έχει διευρυνθεί το περιεχόμενο των αρμοδιοτήτων τους καθώς και η απαίτηση για απόδοση λόγου (accountability). Η μεταφορά των γενικών αρχών του ΝΔΜ στον χώρο της εκπαίδευσης έχει αποτελέσει αντικείμενο αντιπαραθέσεων και έντονων συζητήσεων, με αποτέλεσμα η κριτική που του ασκείται να είναι τόσο επικριτική όσο και υποστηρικτική. Είναι βέβαιο ότι το ΝΔΜ έχει οδηγήσει στην ανάδυση νέων εκπαιδευτικών διαδικασιών προς κατευθύνσεις που δεν θα ήταν εύκολο να προβλεφθούν.
Causes influencing the length of stay of cardiac surgery patients in the intensive care unit
Authors: Dimitropoulou Nikoleta , Stamou Aggeliki , Marvaki Christina 
Published: December 2019

Introduction: The incidence of postoperative morbidity has increased, a fact which may lead to prolonged hospitalization of the patient in the Intensive Care Unit (ICU) and generally in the hospital.Aim: The aim of the present study was to explore the complications after cardiac surgery responsible for the prolonged stay of patients in the ICU.Material and method: The studied sample consisted of 80 patients who were hospitalized in the Intensive Care Unit General Hospital of Athens from January 2013 to June 2014. For data collection a special registration form with information coming from the medical records of patients was used. Data analysis was performed by the IBM SPSS 21.0 (Statistical Package for Social Sciences).Results: Regarding to demographic characteristics Regarding the demographic characteristics and medical history of the studied sample, the majority were male (58.7%, n=47), with a mean age of 73 years and an average hospital stay of 3.3 days. The major causes of prolonged ICU stay was respiratory failure (20%, n=16), arrhythmias (17.5%, n = 14), bleeding (15%, n=12), myocardial infarction (11.3%, n=9), and pulmonary edema (10%,n=8). Τhe bivariate analysis showed statistical relationship to the level of 0,20 (p<0,20) between the prolonged ICU stay and age, coronary artery disease as the cause of entry, coronary artery bypass, diabetes melitus and chronic obstructive pulmonary disease.Conclusion: Patients with a history of heart failure, diabetes or obstructive pulmonary disease seems to have a greater chance for a prolonged ICU stay after cardiac surgery. Early recognition of demographic and clinical factors that may lead to the prolonged ICU stay can provide very important information about how to improve perioperative care of the patient.
Volunteering and nursing, interrelated concepts and values
Authors: Rovithis Michael 
Published: December 2019

Ο εθελοντισμός ορίζεται ως: «η δραστηριότητα εκείνη που αναπτύσσεται κατά τρόπο προσωπικό, αυθόρμητο, ελεύθερο χωρίς ατομικό κέρδος από πολίτες ή ομάδες πολιτών προς το συμφέρον της ομάδας στην οποία ανήκουν ή τρίτων προσώπων ή ευάλωτων κοινωνικών ομάδων ή της τοπικής, κρατικής ή διεθνούς κοινότητας, αποκλειστικά για σκοπούς αλληλεγγύης».1 Ο εθελοντισμός συνεπάγεται μια στάση ζωής που ενστερνίζεται ιδιαίτερες αξίες, όπως η αλληλεγγύη, η κοινωνική δικαιοσύνη, η κοινωνική συμμετοχή, ενώ οι εθελοντές με τη δράση τους προωθούν θετικές στάσεις και αντιλήψεις για τα διάφορα κοινωνικά ζητήματα. Τη σημερινή εποχή, ο εθελοντισμός, αποκτά ριζοσπαστικά χαρακτηριστικά και συνιστά μια μορφή άμεσης παρέμβασης και συμμετοχής των πολιτών, ειδικά των νέων, στο πολιτικό και κοινωνικό γίγνεσθαι.
Pancreatic cystic lesions: comparison of preoperative cytological results by eus-fna with surgical pathologist diagnosis
Authors: Tsimperleniou Maria , Karoumpalis Ioannis , Marvaki Christina , Kadda Olga , Exarchos Dimitrios , Lutrari Eleni 
Published: December 2019

Introduction: The preoperative cytological examination of pancreatic cystic lesions with endoscopic ultrasound and fine needle aspiration biopsy [Endoscopic Ultrasonography (EUS)-Fine Needle Aspiration (FNA)] is of great importance for avoiding unnecessary surgery.Aim: The aim of the present study was to show the importance of EUS-FNA in patients with cystic pancreatic lesions by comparing its results with surgical pathology diagnosis, intending by the selection of appropriate patients for surgery, to reduce preoperative morbidity and mortality and long duration of hospitalization conditions which are responsible for hospital infections as well as public health costs.Material and Methods: This was a prospective observational study. The studied sample consisted of 40 patients with pancreatic cysts. For data collection a specific registration form was used; the demographic characteristics, imaging methods and their results, the symptoms, any previous episodes of pancreatitis, the visualization with EUS, cytological analysis of fluid of pancreatic cysts, and CEA levels and fluid amylase, whenever was possible, as well as the pathologist results of the resected lesions were recorded. Data analysis was performed with the Statistical Package for Social Sciences (SPSS).Results: The sample included 40 patients, 17 men (42.5%) and 23 women (57.5%). The overall operating characteristics of EUS-FNA for pancreatic lesions which were resected, were as follows: sensitivity specificity 81.8% 100.0%, positive predictive value of 100%, negative predictive value 66.0% and 86.7% diagnostic accuracy.Conclusions: The present study confirmed that the EUS-FNA is the method which has high accuracy to select the appropriate patients with pancreatic cystic lesions for therapeutic pancreatectomy.
Estimating the quality of life of hemodialysis patients and adequate clearance
Authors: Prevyzi Evangelia , Argyriou Georgios , Kollia Thomai , Nestor Athanasia , Kotanidou Anastasia , Marvaki Christina 
Published: December 2019

Introduction: Dialysis affects the quality of life of hemodialysis patients due on idrasis in physical activities, psychological factors, and social adaptability. Predominant indicator for assessing the adequacy of dialysis, considered the Kt / V (clearance time/volume of distribution). According to international guidelines, the price which shows adequate dialysis is > 1.2. Aim: The aim of the present study was the association of quality of life of hemodialysis patients with adequate dialysis. Material and Methods: To evaluate the quality of life of hemodialysis patients used the questionnaire KDQOL-SF weighted in the Greek language and the Greek egkyropoiimeno population. Excluded from the study patients with a speaking disability, those who were comatose, aliens, and those undergoing dialysis 3 hours/ 2 times / week. For data processing, used the statistical package SPSS ver.17. Results: Based on the statistical analysis t-test results showed respect to the route of vascular access that patients with graft (31,6%) had a higher clearance rate adequacy, as well as patients undergoing hemodialysis with high permeability (high-flux) filters (35,8%) and those undergoing dialysis with hemodiafiltration (35,8%).According to the statistical criterion pearson's r and multivariate analysis of linear regression, statistically significant difference was only between Kt / V and forefinger encouraging staff and p = 0,032 and p = 0,015 respectively.Conclusions: The conclusions drawn from this study showed that there was no correlation between quality of life and dialysis adequacy, but only with the index of encouraging staff.
Null effect of circulating sphingomyelins on risk for breast cancer: a Mendelian randomization report using Breast Cancer Association Consortium (BCAC) data.
Authors: Adams Charleen D. 
Published: December 2019

Background: Changes in cellular metabolism are a hallmark of cancer and are linked with sphingolipid synthesis. Due to immense interest in how sphingolipids influence chemoresistance, more is known about the impact of sphingolipids during cancer treatment and progression than about the potential role of sphingolipids in the induction of tumors in humans. Methods: Because estrogen triggers sphingolipid signaling cascades, the causal role of circulating levels of sphingomyelin (a type of sphingolipid) on breast cancer was investigated with a well-powered Mendelian randomization design. Results: The results reveal a null effect (OR = 0.94; 95% CI = 0.85, 1.05; P = 0.30). Conclusion: Despite the role sphingomyelins play during chemoresistance and cancer progression, circulating sphingomyelins do not appear to initiate or protect from breast cancer. This finding comprises the first causal report in humans that sphingomyelins on breast cancer initiation is null. Future investigations of risk in other cancer types are needed to further explore the potential role of sphingolipid biology in cancer etiology.
Comparing simulated client experiences with phone survey self-reports for measuring quality of information given in family planning counseling: The case of depot medroxyprogesterone acetate – subcutaneous (DMPA-SC) in Nigeria
Authors: Diamond-Smith Nadia , Treleaven Emily , Omoluabi Elizabeth , Liu Jenny 
Published: December 2019

Background: The quality of family planning services can have important implications for uptake and continued method use. The aim of this analysis is to examine aspects of quality related to information provided for a new injectable contraceptive method, DMPA-SC (depot medroxyprogesterone acetate – subcutaneous, known as Sayana Press®), service provision and contraceptive services more broadly in Nigeria. Methods: We compared self-reports from follow-up phone surveys with users to simulated client interactions that were designed to measure the same concepts. Through mixed-methods, we sought to more deeply understand the biases associated with different data collection methods that ultimately lead to different conclusions regarding quality of information provided in contraceptive services, and to further assess to what extent these methods were suitable for detecting differences in quality across sub-groups using the case of married versus unmarried women. Results: We found that simulated clients reported lower levels of informational quality across all comparable quality indicators than phone survey respondents attending the same facilities. Both methods were able to detect differential treatment by marital status. Conclusions: A mixed-methods approach can provide differential insights into informational quality of family planning services, especially when aiming to understand both objective and subjective aspects of quality.
Cost-effectiveness of oral versus intravenous antibiotics (OVIVA) in patients with bone and joint infection: evidence from a non-inferiority trial
Authors: McMeekin Nicola , Geue Claudia , Briggs Andrew , Rombach Ines , Li Ho Kwong , Bejon Philip , McNally Martin , Atkins Bridget L. , Ferguson Jamie , Scarborough Matthew ,   OVIVA collaborators
Published: December 2019

Background: Bone and joint infections are becoming increasingly common and are usually treated with surgery and a course of intravenous antibiotics. However, there is no evidence to support the superiority of intravenous therapy and there is a growing body of literature showing that oral therapy is effective in treating these infections. Given this lack of evidence the clinical trial ‘Oral Versus Intravenous Antibiotics’ (OVIVA) was designed to assess the clinical and cost-effectiveness of intravenous versus oral antibiotics for the treatment of bone and joint infections, using a non-inferiority design. Clinical results from the trial indicate that oral antibiotics are non-inferior to intravenous antibiotics. The aim of this paper is to evaluate the cost-effectiveness of intravenous compared to oral antibiotics for treating bone and joint infections, using data from OVIVA. Methods: A cost-utility analysis was carried out, the main economic outcome measure was the quality adjusted life-year, measured using the EQ-5D-3L questionnaire, combined with costs to estimate cost-effectiveness over 12-months follow-up. Results: Results show that costs were significantly lower in the oral arm compared to the intravenous arm, a difference of £2,740 (95% confidence interval £1,488 to £3,992). Results of four sensitivity analyses were consistent with the base-case results. QALYs were marginally higher in the oral arm, however this difference was not statistically significant; -0.007 (95% confidence interval -0.045 to 0.031). Conclusions: Treating patients with bone and joint infections for the first six weeks of therapy with oral antibiotics is both less costly and does not result in detectable differences in quality of life compared to treatment with intravenous antibiotics. Adopting a practice of treating bone and joint infections with oral antibiotics early in the course of therapy could potentially save the UK National Health Service over £17 million annually.
ПРОГРАММА РАЗВИТИЯ НАУЧНОГО ЖУРНАЛА «В МИРЕ НАУЧНЫХ ОТКРЫТИЙ» = «SIBERIAN JOURNAL OF LIFE SCIENCES AND AGRICULTURE»
Authors: Magsumov Timur Al’bertovich , Maksimov Yan Alekseevich 
Published: December 2019

Цель. Разработка программы развития журнала, состоящей из комплекса взаимосвязанных мероприятий, направленных на повышение качества содержания издания, улучшение работы редакции, усиление коммуникации и представленности издания в академическом сообществе.Методология. Разработка программы строится на системном подходе, с учетом внешней и внутренней среды функционирования научной периодики. При этом базовыми в исследовании ее состояния и построении перспектив развития стали идеи Дж. Марча об обмене знаниями между стейкхолдерами деятельности журнала, необходимости постоянного привлечения новых участников, балансе между поиском нового и использованием старых проверенных методов, внимании к дисперсии результативности при выстраивании стратегий конкуренции между авторами, превращении информационных технологий в инфраструктуру деятельности редакции, при высокой развитости позволяющую журналу удержать позиции на издательском рынке.Результаты. Журнал, посредством профилизации тематики и проведения ряда организационных мероприятий, уже смог войти в признанные узкопрофильные базы – Chemical Abstracts и Agris. Участие в предлагаемой программе, на наш взгляд, будет способствовать оптимизации и повышению эффективности деятельности издателя и редколлегии по дальнейшему научному «росту» и комплексному развитию издания, что в перспективе позволит ему войти в международные наукометрические базы более «широкого» профиля.Область применения результатов. Являясь стратегическим руководством к изменению политики журнала, трансформации его внутренней среды и выстраивания новых форм взаимоотношений со внешней средой, программа может найти применение и при разработке аналогичных программ развития научных журналов.