bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exosomes derived from cancer stem cells of gemcitabine-resistant pancreatic cancer cells enhance drug resistance by delivering miR-210
Authors: Yang Zhiyong , Zhao Ning , Cui Jing , Wu Heshui , Xiong Jiongxin , Peng Tao 
Published: November 2019

Abstract

Purpose
Gemcitabine (GEM)-based chemotherapy is the first-line treatment for locally advanced pancreatic cancer. GEM resistance, however, remains a significant clinical challenge. Here, we investigated whether exosomes derived from GEM-resistant pancreatic cancer stem cells (CSCs) mediate cell-cell communication between cells that are sensitive or resistant to GEM and, by doing so, regulate drug resistance.

Methods
GEM-sensitive BxPC-3-derived BxS and PANC-1 pancreatic cancer cells were cultured with exosomes extracted from CSCs isolated from GEM-resistant BxPC-3-derived BxR cells (BxR-CSC). The effect of exosomes on drug resistance, cell cycle progression, apoptosis and miRNA expression was evaluated in BxS and PANC-1 cells. Relevant miRNAs associated with GEM resistance were identified and the role of miR-210 in conferring drug resistance was examined in vitro and in vivo.

Results
BxR-CSC-derived exosomes induced GEM resistance, inhibited GEM-induced cell cycle arrest, antagonized GEM-induced apoptosis, and promoted tube formation and cell migration in BxS and PANC-1 cells. Elevated miR-210 expression levels were detected in BxR-CSCs and BxR-CSC-derived exosomes compared to those in BxS-CSCs and BxS-CSC-derived exosomes. In addition, increased expression levels of miR-210 were observed in BxS and PANC-1 cells cultured with BxR-CSC-derived exosomes upon exposure to GEM in a dose-dependent manner. Also, a series of biological changes was observed in BxS cells after transfection with miR-210 mimics, including activation of the mammalian target of rapamycin (mTOR) signaling pathway, and these changes were similar to those triggered by BxR-CSC-derived exosomes.

Conclusions
Our findings suggest that exosomes derived from GEM-resistant pancreatic cancer stem cells mediate the horizontal transfer of drug-resistant traits to GEM-sensitive pancreatic cancer cells by delivering miR-210.
Performance Evaluation and Social Optimization of an Energy-Saving Virtual Machine Allocation Scheme Within a Cloud Environment
Authors: Wang Xiushuang , Zhu Jing , Jin Shunfu , Yue Wuyi , Takahashi Yutaka 
Published: November 2019

AbstractAchieving greener cloud computing is non-negligible for the open-source cloud platform. In this paper, we propose a novel virtual machine allocation scheme with a sleep-delay and establish a corresponding mathematical model. Taking into account the number of tasks and the state of the physical machine, we construct a two-dimensional Markov chain and derive the average latency of tasks and the energy-saving degree of the system in the steady state. Moreover, we provide numerical experiments to show the effectiveness of the proposed scheme. Furthermore, we study the Nash equilibrium behavior and the socially optimal behavior of tasks and carry out an improved adaptive genetic algorithm to obtain the socially optimal arrival rate of tasks. Finally, we present a pricing policy for tasks to maximize the social profit when managing the network resource within the cloud environment.
A repository of real-world datasets for data-driven evolutionary multiobjective optimization
Authors: He Cheng , Tian Ye , Wang Handing , Jin Yaochu 
Published: November 2019

Abstract
Many real-world optimization applications have more than one objective, which are modeled as multiobjective optimization problems. Generally, those complex objective functions are approximated by expensive simulations rather than cheap analytic functions, which have been formulated as data-driven multiobjective optimization problems. The high computational costs of those problems pose great challenges to existing evolutionary multiobjective optimization algorithms. Unfortunately, there have not been any benchmark problems reflecting those challenges yet. Therefore, we carefully select seven benchmark multiobjective optimization problems from real-world applications, aiming to promote the research on data-driven evolutionary multiobjective optimization by suggesting a set of benchmark problems extracted from various real-world optimization applications.
Cell Nanomechanics Based on Dielectric Elastomer Actuator Device
Authors: Li Zhichao , Gao Chao , Fan Sisi , Zou Jiang , Gu Guoying , Dong Mingdong , Song Jie 
Published: November 2019

AbstractAs a frontier of biology, mechanobiology plays an important role in tissue and biomedical engineering. It is a common sense that mechanical cues under extracellular microenvironment affect a lot in regulating the behaviors of cells such as proliferation and gene expression, etc. In such an interdisciplinary field, engineering methods like the pneumatic and motor-driven devices have been employed for years. Nevertheless, such techniques usually rely on complex structures, which cost much but not so easy to control. Dielectric elastomer actuators (DEAs) are well known as a kind of soft actuation technology, and their research prospect in biomechanical field is gradually concerned due to their properties just like large deformation (> 100%) and fast response (< 1 ms). In addition, DEAs are usually optically transparent and can be fabricated into small volume, which make them easy to cooperate with regular microscope to realize real-time dynamic imaging of cells. This paper first reviews the basic components, principle, and evaluation of DEAs and then overview some corresponding applications of DEAs for cellular mechanobiology research. We also provide a comparison between DEA-based bioreactors and current custom-built devices and share some opinions about their potential applications in the future according to widely reported results via other methods.
Negotiating Legal Reform through Reception of Law: The Missing Role of Mixed Legal Transplants
Authors: TRAN Kien , PHAM Nam Ho , NGUYEN Quynh-Anh Lu 
Published: November 2019

AbstractOur research proposes ‘mixed legal transplant’ as a new concept in theories of legal transplantation. While the concept of legal transplantation is real, the phenomenon is much more complicated than what is often depicted and discussed by the academic community. In modern times, legal transplantation is often an informed reception by independent sovereign nations or people of two or more sets of rules from different jurisdictions, rather than a simplistic and passive reception of rules from one country to another. Using Vietnam as a case study, this article analyzes the deliberate consideration of two different models of precedent in the civil and common law traditions by Vietnamese lawmakers, and their choice of a mixed legal transplant in the hope that it would be best suited to the needs of a socialist country in transition. Its methods and results, however, are still in doubt and have been criticized as possibly creating uncertainty due to their structural incoherence. This article therefore concludes by proposing recommendations based on legal tradition to correct the misuse of the mixed legal transplant in Vietnam, and we hope that these recommendations can serve as a model for other countries.
Climate Change as a Business and Human Rights Issue: A Proposal for a Moral Typology
Authors: TOFT Kristian Høyer 
Published: November 2019

AbstractTo explore the emerging and contested issue of business and human rights in the area of climate change, this article provides a critical discussion from the viewpoint of moral philosophy. A novel typology of businesses’ human rights duties (‘duty’ is considered synonymous with ‘responsibility’ here) is proposed. It claims that duties are both forward- and backward-looking. Cases of human rights litigation seeking remedy for climate-related harms are backward-looking, and duties should be determined on the basis of proportion of historical emissions, culpable knowledge and counter-acts to abate climate harms. Businesses’ forward-looking duties, however, depend on their power, privilege, interest and collective abilities. The typology is then assessed against the background of recent legal principles and instruments. It is concluded that moral duties of business reach beyond mere respect for human rights and national jurisdictions in the context of climate change.
Statistical inference for multilayer networks in political science
Authors: Chen Ted Hsuan Yun 
Published: November 2019

AbstractInteractions between units in political systems often occur across multiple relational contexts. These relational systems feature interdependencies that result in inferential shortcomings and poorly-fitting models when ignored. General advancements in inferential network analysis have improved our ability to understand relational systems featuring interdependence, but developments specific to working with interdependence that cross relational contexts remain sparse. In this paper, I introduce a multilayer network approach to modeling systems comprising multiple relations using the exponential random graph model. In two substantive applications, the first a policy communication network and the second a global conflict network, I demonstrate that the multilayer approach affords inferential leverage and produces models that better fit observed data.
Dangerous Contenders: Election Monitors, Islamic Opposition Parties, and Terrorism
Authors: Kavakli Kerim Can , Kuhn Patrick M. 
Published: November 2019

AbstractHow do international observers decide whether to criticize or condone electoral fraud in a country? We argue that this decision depends on the identity of the victims of electoral fraud. A monitoring organization is more likely to overlook fraud committed against groups that are deemed dangerous by its sponsor. Based on this insight, we hypothesize that in the post-Cold War era election monitors are more tolerant of fraud against Islamic challengers, especially when Islamic movements are perceived as a threat to political stability. In support of our hypothesis, we find that outside monitors are more likely to endorse an election in countries with an Islamic opposition party and an ongoing Islamist terrorist campaign. Furthermore, we find that the effect is driven by Western monitoring organizations and becomes stronger after the September 11 attacks. Our findings provide a simple yet powerful insight: the calculus of outside observers depends not only on who they wish to see in power, but also who they want to keep from power.
Linkage in stunting status of siblings: a new perspective on childhood undernutrition in India
Authors: Banerjee Kajori , Dwivedi Laxmi Kant 
Published: November 2019

AbstractAlmost 30% of the world’s stunted children reside in India. This study examined sibling linkage in childhood stunting by assessing the extent of clustering of stunted children born to the same mother. Data were taken from 225,002 children under the age of five from the Indian National Family and Health Survey (NFHS)-4 conducted in 2015–16. States with high fertility and lower socioeconomic development displayed higher clustering of childhood stunting among siblings. Simulating removal of this clustered burden showed an almost 10 percentage point reduction in stunting in India. Multinomial regression analysis highlighted that the propensity to have multiple stunted births was higher among less-educated women, scheduled caste/tribes and poor households. The multilevel model results indicated that the odds of stunting for the index child increased by 1.93 if the older sibling was stunted. The odds of the index child being stunted if the previous child was stunted were high, irrespective of the differences in state-level public health performances and political commitments. Although socioeconomic correlates play a crucial role in determining child stunting status, they also act as proxies for poor-quality intra-generational health. Clustering of stunting among siblings is an indicator of both genetic and environmental association with the height-for-age (HAZ) of children. Mothers with repeated stunted births should be prioritized and monitored over a substantial part of their lives. Inclusion of multiple child beneficiaries in nutrition policies and revisiting the ‘one size fits all’ concept at the micro level, owing to the substantial village/ward-level variation, might be an effective policy measure.
Molecular identity of the non-indigenous Cassiopea sp. from Palermo Harbour (central Mediterranean Sea)
Authors: Maggio Teresa , Allegra Alessandro , Bosch-Belmar Mar , Cillari Tiziana , Cuttitta Angela , Falautano Manuela , Milisenda Giacomo , Nicosia Aldo , Perzia Patrizia , Sinopoli Mauro , Castriota Luca 
Published: November 2019

AbstractThe upside-down jellyfish Cassiopea is a benthic scyphozoan, considered a non-indigenous invasive species in the Mediterranean, forming large blooms in eutrophic areas. Taxonomy of the genus Cassiopea is extremely difficult because morphological/meristic characters used are variable within the same species, overlapping among different species, and cryptic species have been identified by molecular markers; nine Cassiopea species are recognized on the basis of molecular study. Mediterranean records of Cassiopea have been ascribed to andromeda species on the basis of a hypothesized invasion pathway from the Suez Canal. In the current study, an analysis of the main morphological characters of the sampled Cassiopea jellyfish from Palermo (Tyrrhenian Sea) was carried out and subsequently, molecular analyses were performed by using COI barcode in order to identify the species. Molecular data were compared with published information in GenBank. Morphological characters were highly variable, but molecular analyses confirmed that Mediterranean Cassiopea specimens belong to andromeda species. Moreover, high values of sequence divergence were found between Mediterranean Cassiopea and the other C. andromeda from the Red Sea, Hawaii and Florida. These results lead to a discussion of possible explanations linked to life history features of the species. Two different explanations are proposed; the first is that Mediterranean C. andromeda, finding a suitable ecological niche good for colonization and proliferation, could have been isolated in Palermo Harbour. The second considers the possibility of multiple introduction events by human transport as demonstrated for other non-indigenous jellyfish; in this case Cassiopea genetic differences increased in the invaded area.
Regulation of cell adhesion: a collaborative effort of integrins, their ligands, cytoplasmic actors, and phosphorylation
Authors: Gahmberg Carl G. , Grönholm Mikaela , Madhavan Sudarrshan , Jahan Farhana , Mikkola Esa , Viazmina Larisa , Koivunen Erkki 
Published: November 2019

AbstractIntegrins are large heterodimeric type 1 membrane proteins expressed in all nucleated mammalian cells. Eighteenα-chains and eightβ-chains can combine to form 24 different integrins. They are cell adhesion proteins, which bind to a large variety of cellular and extracellular ligands. Integrins are required for cell migration, hemostasis, translocation of cells out from the blood stream and further movement into tissues, but also for the immune response and tissue morphogenesis. Importantly, integrins are not usually active as such, but need activation to become adhesive. Integrins are activated by outside-in activation through integrin ligand binding, or by inside-out activation through intracellular signaling. An important question is how integrin activity is regulated, and this topic has recently drawn much attention. Changes in integrin affinity for ligand binding are due to allosteric structural alterations, but equally important are avidity changes due to integrin clustering in the plane of the plasma membrane. Recent studies have partially solved how integrin cell surface structures change during activation. The integrin cytoplasmic domains are relatively short, but by interacting with a variety of cytoplasmic proteins in a regulated manner, the integrins acquire a number of properties important not only for cell adhesion and movement, but also for cellular signaling. Recent work has shown that specific integrin phosphorylations play pivotal roles in the regulation of integrin activity. Our purpose in this review is to integrate the present knowledge to enable an understanding of how cell adhesion is dynamically regulated.
The Politics of Order in Informal Markets: Evidence from Lagos
Authors: Grossman Shelby 
Published: November 2019

AbstractProperty rights are important for economic exchange, but in many parts of the world, they are not publicly guaranteed. Private market associations can fill this gap by providing an institutional structure to enforce agreements, but with this power comes the ability to extort from group members. Under what circumstances do private associations provide a stable environment for economic activity? The author uses survey data collected from 1,179 randomly sampled traders across 199 markets in Lagos, Nigeria, and finds that markets maintain institutions to support trade not in the absence of government, but rather in response to active government interference. The author argues that associations develop protrade policies when threatened by politicians they perceive to be predatory and when the organizations can respond with threats of their own. The latter is easier when traders are not competing with one another. To maintain this balance of power, an association will not extort; it needs trader support to maintain the credibility of its threats to mobilize against predatory politicians.
Texting the future in Belgium and Québec: Present matters
Authors: Tremblay Mireille , Blondeau Hélène , Labeau Emmanuelle 
Published: November 2019

AbstractThis study investigates the variation in the expression of Future Temporal Reference in text messages in Belgian and Québécois French. Three variants are considered: the Futurate Present, the Synthetic Future and the Analytic Future. The results of multivariate analyses show that the use of the Futurate Present does not appear to be subject to dialectal variation: both communities use this variant at similar rates, and the use of the variant is constrained by the same linguistic factors. The two dialects show differences in their choice of the Synthetic vs the Analytic Future. Unlike Québécois French, Belgian French strongly favours the Synthetic Future. The two dialects also differ with respect to the linguistic constraints in effect. Our analysis shows the need to explore the relationship between variants, and to distinguish between Covert T (realized as Present tense) and Overt T (either Synthetic or Analytic Future). Our results point toward the hybrid nature of text messages: while our results show patterns of use in line with oral/conversational corpora as reflected by the dialectal variation observed, text messages are not exempt from the influence of written French, as shown by the use of Synthetic Future forms in affirmative sentences in the Québec corpus.
Introduction: historical perspectives on pedestrians and the city
Authors: Pooley Colin , Emanuel Martin , Männistö-Funk Tiina , Norton Peter 
Published: November 2019

AbstractWalking is a neglected topic in the history of transport and mobility in cities. The four articles in this special section demonstrate the importance of travel on foot in nineteenth- and twentieth-century cities in four different countries, and reveal the ways in which pedestrian mobility has persisted despite the development of a car-dominated society. Together they provide important new evidence on a neglected topic and hopefully pave the way for further research on this theme.
The Chinese National Twin Registry: A Unique Data Source for Systems Epidemiology of Complex Disease
Authors: Huang Tao , Gao Wenjing , Lv Jun , Yu Canqing , Wu Tao , Wang Shengfeng , Liao Chunxiao , Meng Lu , Wang Dongmeng , Wang Zhaonian , Pang Zengchang , Yu Min , Wang Hua , Wu Xianping , Dong Zhong , Wu Fan , Jiang Guohong , Wang Xiaojie , Liu Yu , Deng Jian , Lu Lin , Cao Weihua , Li Liming 
Published: November 2019

AbstractThe Chinese National Twin Registry (CNTR), initiated in 2001, has now become the largest twin registry in Asia. From 2015 to 2018, the CNTR continued to receive Chinese government funding and had recruited 61,566 twin-pairs by 2019 to study twins discordant for specific exposures such as environmental factors, and twins discordant for disease outcomes or measures of morbidity. Omic data, including genetics, genomics, metabolomics, and proteomics, and gut microbiome will be tested. The integration of omics and digital technologies in public health will advance our understanding of precision public health. This review introduces the updates of the CNTR, including study design, sample size, biobank, zygosity assessment, advances in research and future systems epidemiologic research.
The Application of the SVD Method to Reduce Coupled Model Biases in Seasonal Predictions of Rainfall
Authors: Lin Renping , Zhu Jiang , Zheng Fei 
Published: November 2019

AbstractThe large systematic biases in coupled models impact seasonal prediction results. With a motivation to reduce the influence of coupled‐model biases on seasonal predictions, the singular value decomposition method was applied in our study to improve the ability to predict flood season precipitation. Based on the coupled climate model, CAS‐ESM‐C, we conducted ensemble seasonal prediction experiments from 1982 to 2018, with initial conditions provided by the assimilation system. The prediction system was integrated from March to August of each year with a focus on the June to August precipitation in China. The results showed that the prediction skills for anomalous summer precipitation were very low without bias corrections. However, the system effectively predicted the interannual variabilities in large‐scale atmospheric circulation systems that were associated with anomalous summer precipitation. We used the singular value decomposition method to reduce pattern‐dependent precipitation errors by replacing prediction patterns with observation patterns, and the predictive skill for precipitation dramatically improved. The results demonstrated that this correction method is a viable tool to reduce systematic biases in coupled model predictions.
Local and Nonlocal Land Surface Influence in European Heatwave Initial Condition Ensembles
Authors: Merrifield A. L. , Simpson I. R. , McKinnon K. A. , Sippel S. , Xie S.‐P. , Deser C. 
Published: November 2019

AbstractDry land surface conditions have been shown to amplify extreme heat events in Europe, but the extent to which this influence involves modification of the overlying atmospheric circulation has yet to be fully established. Here, this issue is addressed using two Community Earth System Model ensembles, with the same heatwave‐inducing atmospheric circulation pattern imposed over different land surface states. These two ensembles differ in the vertical level above which the circulation is constrained (surface vs. upper troposphere). Soil moisture anomalies are found to play an important role in dictating heatwave intensity among ensemble members. The heatwave is approximately 0.1°C hotter per standard deviation soil moisture reduction when the troposphere is free to respond to surface conditions than when it is constrained, implying that a portion of the land surface influence involves feedbacks through the atmospheric circulation. The additional atmospheric response also allows for nonlocal heatwave amplification in subsequent months.