bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health Effects of Abdominal Liposuction in Newly Diagnosed Type 2 Diabetes
Authors: ELkayal A H , Hefny A M , Mahmoud B A , Anany A M A 
Published: May 2020

Abstract

Background
Diabetes Mellitus (DM) is a metabolic disorder characterized by the presence of chronic hyperglycaemia accompanied by greater or lesser impairment in the metabolism of carbohydrates, lipids and proteins. DM is probably one of the oldest diseases known to man. It was first reported in Egyptian manuscript about 3000 years ago. In 1936, the distinction between type 1 and type 2 DM was clearly made. Type 2 DM was first described as a component of metabolic syndrome in 1988. The origin and aetiology of DM can vary greatly but always include defects in either insulin secretion or response or in both at some point in the course of disease.

Objective
The aim of this study is to evaluate the effectiveness of abdominal liposuction in improving quality of life in newly diagnosed uncomplicated type 2 diabetic patients.

Methodology
This study will take place in plastic Surgery Department, Port Said general Hospital. As total number of cases satisfying inclusion criteria not exceed 6 cases per month during the study period (3 months) the total sample 3x6=18 cases all will be included as comprehensive sample.

Results
In our study, the mean FPG was 163 ± 22 mg/dl preoperatively. At three months after surgery, it was 162 ± 29 mg/dl, but at six months after surgery, it was 147 ± 28 mg/dl. The mean PPBG was 218 ± 40 mg/dl preoperatively. At three months after surgery, it was 216 ± 40 mg/dl, but at six months after surgery, it was 200 ± 34 mg/dl. The mean HbA1c percentage was 8 ± 0.8% preoperatively. At three months after surgery, it was 7.7 ± 0.8%, but at six months after surgery, it was 7.6 ± 0.8%. The mean triglyceride level was 180 ± 48 preoperatively. At three months after surgery, it was 162 ± 41, but at six months after surgery, it was 159 ± 49. The mean cholesterol was 207 ± 42 preoperatively. At three months after surgery, it was 197 ± 52, but at six months after surgery, it was 189 ± 41. The HOMA-IR was 3 ± 0.7 preoperatively. At three months after surgery, it was 2.8 ± 0.7, but at six months after surgery, it was 2.8 ± 0.7. All the laboratory investigations change over time among the studied patients were not statistically significant.

Conclusion
So, we can conclude that large-volume abdominal liposuction should not, by itself, be considered a clinical therapy for type 2 diabetes mellitus. Aspiration of large amounts of subcutaneous abdominal fat in diabetic patients, despite having cosmetic benefits, It does not significantly improve insulin sensitivity through altering serum levels of obesity markers. Therefore, the procedure is safe and may could successfully help diabetic subjects to reduce their potential metabolic risks. Therefore, abdominal Liposuction is effective scarless operation for subcutaneous adipose fatty tissue reduction.
The ability of the Society for Vascular Surgery Wound, Ischemia and Foot Infection (WIFI) Classification system to predict risk of amputation in patients with non-healing ulcer during the first year atAin Shams University Hospitals
Authors: Salib W F , Desokey A A , Wahba R M , Zayed M O 
Published: May 2020

Abstract

Background
Classification systems are powerful tools for health care providers to use when managing patients with threatened limbs. The ability to define and delineate a heterogeneous group into fine-grained cohorts not only aids communication between providers, it allows for a more accurate analysis of outcomes across treatment strategies. Thus, classification systems are essential for clinical decision making as well as setting meaningful goals and expectations with patients and their families.

Aim of the Work
to evaluate the predicative ability of this classification in a real world selection at Ain Shams University at period of 1 year depending on the Society for Vascular Surgery Wound, Ischemia and Foot Infection (WIFI) classification system.

Patients and Methods
This study included 60 patients with non-healing wound ulcer at Ain Shams University hospitals during year 2017 and 2018.

Results
As our study showed WIfI classification was predictive of 1 year limb amputation and wound non healing and correlated significantly with outcomes predicted by the SVS consensus panel. The study showed 1 year amputation rates were 0% for stage 1, 7.7% for stage 2, 18.75% for stage 3 And 64.7% for stage 4. It also showed among the 60 patients studied 15 patients had done amputations where 6.7% were stage 2, 20% were stage 3 and 73.7% were stage 4.

Conclusion
WIFI classification can be very useful in predicting the possibility of amputation during 1 year; also the study showed the benefit of using WIFI to plan management of patients presented with foot ulcer.
Outcomes of skin sparing mastectomy with immediate breast reconstruction with Latissimus dorsi (LD) flap in surgical treatment of breast cancer
Authors: Othman S M , Elfekky A K , Elshinawi M E , Othman A G 
Published: May 2020

Abstract

Introduction
Breast cancer is a devastating disease affecting women of all ages worldwide with the age incidence in Egypt being one decade younger than the mean age incidence, the latissimus dorsi (LD) flap is an important volume-replacement option due to its stability and versatility as an autologous flap. LD flap could be used for total breast reconstruction after mastectomy in selective cases or to fill a large quadrantectomy defect.

Aim
The aim of this study is to estimate the oncologic and aesthetic outcomes and the procedure-related complications of latissimus dorsi (LD) flap with skin sparing mastectomy in management of breast cancer.

Patients
On 25 patients breast cancer underwent skin-sparing mastectomy with immediate reconstruction using LD flap,

Methods
All patients were subjected to : (Complete history taken, General examination, Local examination and routine investigations) Surgical procedures

25 patients with breast cancer underwent skin-sparing mastectomy with immediate reconstruction with LD flap.

Results
Mean age of included patients was 41.12 years with mean BMI 29.17 kg/m2, regarding tumor classification DCIS represented 8% LCIS represented 20% IDC represented 32% ILC represented 40% of all patients, Positive lymph node 1-3 in 40% of patients and more than 3 in 20% of patients and 40% of patients had negative lymph node,96% of patients had no recurrence on the other hand only 4% shows locoregoinal recurrence, Regarding postoperative immediate complications 72% of patients showed no complications.

Discussion
In the current study we aimed to estimate the oncologic and aesthetic outcomes and the procedure-related complications of latissimus dorsi (LD) flap with skin sparing mastectomy in management of breast cancer.

Conclusion
Skin sparing mastectomy with immediate breast reconstruction using latissimus dorsi muscular flap allows single-stage, totally autologous reconstruction with a satisfactory aesthetic result, low morbidity, and good quality of life.

Recommendations
Breast cancer patients are best managed by a multidisciplinary team, Breast conservation surgery does often leave a significant deformity which can best be corrected by an immediate LD flap reconstruction, this method is simple and effective, our concept should be further analyzed in larger comparative studies.
Value of the Ultrasound Elastography in the Diagnosis of Thyroid Nodules
Authors: Ouf T I A , Hanna H H , Ghaly A M B 
Published: May 2020

Abstract

Background
Thyroid disease is of common occurrence, especially in iodine deficient areas. Thyroid nodules have been reported in as many as 50% of the population, at autopsy. They may be discovered in up to 41% of the patients at ultrasonography (US).

Aim of the Work
The aim of this study is to evaluate the value of Ultrasound- Elastography in the Diagnosis of thyroid nodules for reducing the number of unnecessary Thyroidectomises which add burden to the patient and community, consequently the complications of this surgery will be reduced.

Patients and Methods
This prospective cohort study was conducted at El Demerdash, Ain Shams University Hospital on Fifty (50) patients with the diagnosis of multi-nodular goiter, who were treated by total thyroidectomy between November 2016 and November 2018 with minimum follow up of one month postoperatively. An informed consent was taken from all patients who accepted to participate in our study after ethical committee approval.

Results
Elastography has 100% sensitivity and 95.5% specificity as it suspected malignancy (positive suspecting findings) in 8 patients; six of them were proved to be malignant and two of them were benign by histopathology accounting for high positive predictive value (75%) and it suspected benignity (negative suspecting findings) in 42 patients; all of them were perfectly correlated with the histopathology accounting for high negative predictive value (100%). These results showed nearly the same values of the Elastography in the previous studies had been done regarding this concern.

Conclusion
Conclusively, In the future, FNAC perhaps will not be used for the diagnosis of malignancy in patients presented with multi-nodular goitres who were diagnosed as suspicious of malignancy by Sono-elastography.
Mortality rate in patients with Secondary Peritonitis in Ain Shams University Hospitals as regard Mannheim Peritonitis Index (MPI) score
Authors: Ouf T I , Jumuah W A A , Mahmoud M A , Abdelbaset R I 
Published: May 2020

Abstract

Introduction
Secondary peritonitis is one of the most common fatal surgical emergencies. The mortality rate is about 20% even in well- equipped places. The outcome can be improved be rapid surgical intervention and intensive care of the patient. Many scoring systems were developed to identify high-risk patients who may need rapid intervention or intensive care. Mannheim Peritonitis Index (MPI) is an easy and specific score for predicting the outcome of secondary peritonitis.

Patients and Method
It’s an observational prospective study over 50 patients presented with secondary peritonitis to our E.R during the period from January 2018 to June 2018 and patients were followed up for one month. Patients were divided into three groups according to their MPI score, Group I: with MPI score less than 21, Group II: with MPI score between 21 and 29, and Group III: with MPI score more than 29.

Results
In the present study, Mortality rate was about 24%. Mortality rates in those groups were 0%, 5.5% and 55% respectively which are similar to results of other studies performed in other places. Cut-off value is 28 with sensitivity 91% and specificity 76%.

Conclusion
MPI score is effective in predicting outcome of patients with secondary peritonitis in our hospitals.
The Possible Therapeutic Role of Platelet Rich Plasma on a Model of Osteoarthritis in Male Albino Rat. Histological and Immunohistochemical Study
Authors: Gamal N , Abourabia N M , Elebiary F H , Khalaf G , Raafat M H 
Published: May 2020

Abstract

Introduction and Aim of the Study
Osteoarthritis (OA) is a degenerative joint disease characterized by joint pain and progressive loss of articular cartilage. This study was conducted to evaluate the therapeutic effect of platelet-rich plasma (PRP) of the knee joint in a rat model of OA.

Materials and Methods
Forty adult male albino rats, weighing 200-250 gms, were used in this study, ten rats used as donors to obtain PRP. The other thirty rats were divided into two main groups. Group I: The control group (15 rats) in which the rats were subdivided into three subgroups. Subgroups IA and IB were sacrificed 4 and 6 weeks after the beginning of the experiment. Subgroup IC left for 4 weeks then received intra-articular injection of PRP in the right knee joint which was repeated three times per week for 2 weeks then the animals were sacrificed. Group II (The experimental group) (15 rats) in which OA was induced by surgical induction of cartilaginous defect in the right knee joints. The rats of group II were subdivided into three subgroups. Subgroups IIA and IIB were sacrificed 4 and 6 weeks after induction of OA respectively. Subgroup IIC received intra-articular injection of PRP (0.2 ml) in the right knee joints 4 weeks after surgery. The injection was repeated three times per week for 2 weeks then the animals were sacrificed. The right joints from all groups were collected, decalcified and processed for histological studies. Specimens were also processed for transmission electron microscopic study. Morphometric and statistical measurements were done.

Results
Histological examination of the right knee joints of OA (subgroups IIA and IIB) resulted in thickening of the intimal lining of the synovial membrane, cellular infiltration and increased collagen content of the subintima. The articular cartilage showed erosions, thinning of cartilage, chondrocytes and ground substance loss, and moderate expression of platelet derived growth factor (PDGF). Injection of PRP resulted in improvement of the structure of the synovial membrane and the articular cartilage and strong expression of PDGF.

Conclusion
Intra-articular injection of PRP resulted in a significant improvement in the histological structure of the knee joint in a rat model of OA.
Comparative study on the effect of adipose-derived stem cells versus alpha-lipoic acid in autologus fat graft survival in adult female albino rat: histological and immune histochemical study
Authors: Ibrahim S H , Omar S M M , Ibrahim G A , Omar A E 
Published: May 2020

Abstract

Background
Autologous fat transfer is a popular option for soft tissue augmentation, but has a low survival rate. So, enriching the transplanted fat with stem cells (cell assisted lipotransfer) or oral administration of alpha-lipoic acid (ALA) before and after graft injection, were thought to increase the survival rate of the transplanted fat.

Aim of Study
Is to compare between cell-assisted lipotransfer (CAL) and ALA therapy in improvement of fat graft survival.

Materials and Methods
Thirty adult female albino rats were used and divided into three groups. Group I: the control group. Group II: CAL group received autologous fat mixed with adipose derived stem cells (ASCs). Group III: ALA group in which animals received oral ALA four days before fat transplantation and continued throughout experiment. Fat grafts were collected from the sites of injection after twenty-eight days. Histological and immune histochemical studies were performed. Statistical analysis was also done.

Results
Histological evaluation of the fat grafts from animals of control group revealed atrophy and death of adipocytes with formation of fat cysts. Severe inflammatory infiltration with giant cells formation and fibrosis were detected. Significant decrease of VEGF reaction was seen. In CAL group significant increase in number of intact adipocytes together with decrease in inflammation and fibrosis occurred. Moreover, significant increase in VEGF reaction was observed. In ALA group, significant decrease in number of intact adipocytes and VEGF reaction was detected compared with CAL group. Also, significant increase in inflammatory infiltration and fibrosis were detected compared to CAL group.

Conclusions
Both ASCs and ALA showed improvement in all histological parameters compared with control group. However, enrichment of fat with ASCs showed the best results.
The Effect of Diet Carbonated Drinks and Monosodium Glutamate on the Cerebellar Cortex and the Kidney of Adult Male Albino Rats. Histological and Immuno- histochemical Study
Authors: Abdelwahed N A A , Geith E Z , Kalleny N K , Abdelkhalek H A 
Published: May 2020

Abstract

Background
The consumption of fast- food is increasing among children, adolescents and adults. Carbonated drinks are widely consumed with fast food that also exists in the form of diet drinks as Diet Coke. One of the thousands of chemicals used in our new high-tech foods is the monosodium glutamate (MSG).

Aim of the Study
This study was conducted to investigate the effect of Diet Coke and monosodium glutamate salt either separately or in combination on the cerebellar cortex and kidney of adult male albino rats.

Materials and Methods
Twenty five adult male albino rats were divided into four groups. Group I: control group (10 rats) divided equally into two subgroups, subgroup IA in which rats had free access to food and water and subgroup 1B in which each rat administrated 0.5 ml of distilled water once daily by oral gavage. Rats had free access to food and water. Group II (5 rats): in which rats received Diet Coke instead of water throughout the day. Group DI (5 rats): in which each rat received 0.5m1 of MSG salt solution by dose of 3ern MSG/kgm by oral gavage once daily. Group IV (5 rats): in which each rat received Diet Coke instead of water throughout the day and 0.5m1 of MSG salt solution by dose of 3gm MSG/kgm by oral gavage once daily. Cerebella and kidneys were dissected out and processed for histological, immunohistochemical and morphometric studies.

Results
Histological examination of the cerebellum and the kidney revealed that both Diet Coke and MSG either separately or in combination resulted in degenerative changes that were more significant in the combination group. The cerebellum showed degeneration of Purkinje cells and vaculations in the molecular layer. The kidney showed shrunken glomeruli, vacuolations of cells lining renal tubules with pyknotic nuclei. Hyaline debris detected in renal sections of combination group.

Conclusion
Diet Coke and MSG induced degenerative changes in both the cerebellum and the kidney that was more significant in their combination.
New rational in Treatment of Parkinsonism
Authors: Abdelkawy S A , Elsebay S A , Abdelhafez S M N , Ibrahim M F G 
Published: May 2020

Abstract
Parkinsonism disease is the second most common aging neurodegenerative disorders characterized by degeneration of dopaminergic neurons settled in the substantia nigra, leading to the appearance of both motor and non-motor symptoms. This work aims to show the effect of stem cell therapy on treatment of Parkinsonism and also to show the mechanism of the action.
In this work, Parkinsonism was induced by subcutanous injection of rotenone. Rats were divided randomly in to 3 groups; control, Parkinsonism, stem cell. Brain specimens were obtained for histological study.
In Parkinsonism group, marked pathological changes were noticed in the form of; shrunken dopaminergic cells with pyknotic nuclei.
Interestingly, improvement of some of the pathological changes was observed in the stem cell group.
It could be concluded that, stem cell has a beneficial effect in management of Parkinsonism and this need further investigations in the future.
Risk factors predicting Cytomegalovirus infection in post liver transplant recipients
Authors: Abdelrahman M G , Mahmoud H A , Mohsen M K , Ali M O , Mohamed A M N 
Published: May 2020

Abstract

Background
Liver transplantation is considered to be the only curative treatment for patients with end stage liver disease. Postoperative infection remains to be one of the most common causes of morbidity and mortality throughout the past years. Cytomegalovirus (CMV) infection although considered to be a weak viral infection that usually passes asymptomatic in immunocompetent patients, however, it is considered one of the most common pathogens causing morbidities and mortality in liver transplant recipients. Multiple studies have been done to assess the risk factors for developing CMV infection.

Objective
Identification of risk factors predicting Cytomegalovirus infection in liver transplant recipients following transplantation.

Methods
This retrospective study was conducted on 194 patients and their donors who underwent living donor liver transplantation operation at Ain Shams centre for organ transplantation (ASCOT) at Ain Shams specialized hospital in the period between January 2010 and December 2016 with at least one year follow up period after operation for the recipient group.

Results
In our study, 194 patients undergoing liver transplantation at Ain shams centre for organ transplantation over seven years from January 2010 to December 2016 have been followed to assess risk factors affecting CMV infection development. Chronic rejection was found to be the most common factor associated with CMV infection followed by Cyclosporin (Neoral) as main postoperative immunosuppressant following liver transplantation. Other factors that were found to carry risk for CMV infection included younger age, advanced MELD score, positive CMV IgM status of the donors and recipients.

Conclusion
Differentiation of Cytomegalovirus disease from Cytomegalovirus infection isn’t always available as it requires tissue invasive techniques. Multiple risk factors have been attributed to cause Cytomegalovirus infection (viremia) . In our study, rejection (chronic rejection) was the factor that carries highest risk for Cytomegalovirus infection development followed by Cyclosporin .
Evaluation of serum sclerostin level and its correlation with valvular calcification in haemodialysis patients
Authors: Gohar S A , Hebah H A , Kheidr A N , Rasheed A M 
Published: May 2020

Abstract

Background
The majority of hemodialysis patients are affected by the cardiovascular calcification. Vascular/valvular calcification contributes to an extremely high cardiovascular morbidity and mortality in HD patients.

Objective
To asses circulating levels of Scl in ESRD patients receiving HD and their relation to aortic and mitral valve calcification detected by echocardiography as well.

Patients and Methods
The study included 80 ESRD patients undergoing HD in Al-Sahel Nephrology and Dialysis unit. Routine chemical investigations, serum sclerostin by ELISA were done to all patients, as well a trans-thoracic Echocardiography.

Results
serum Scl level ranged from 0.41 ng\ml to 1.65 ng\ml. calcification was documented in 53/80 (66.2%) of our HD patients: 26/80 had aortic valve calcification only(32.5%), 6/80 patients (7.5%) had mitral valve calcification alone, while 21/80 of patients had both aortic and mitral valves calcification (26.25%). 27/80 (33.75%) patients had no calcification. We didn’t find any significant correlation between serum Scl level and valvular calcification nor age, sex or HD duration.

Conclusion
valvular calcification are prevalent in HD population. Serum Scl was not associated with valvular calcification.