bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-Assembled Monolayers of Vitamin B12 over N-Doped Graphene: A Promising Electro-Catalyst for Hydrogen Evolution and Electro-Oxidative Sensing of H2O2
Authors: Bhat Mohsin A , Bhat Sajad A 
Published: February 2020

The redox, chemical and biochemical characteristics of molecular hydrogen (H2) and hydrogen peroxide (H2O2) promise sustainable, economically and environmentally friendly means to address some serious global issues related to energy, environment and human health. However, the non-availability of a cheap, efficient and durable electrocatalyst continues to hamper the practical exploitation of H2 and H2O2 as solution to these challenges. In the work to be presented, we shall present a simple strategy for the self-assembling of Vitamin B12 (Vit.B12) over nitrogen-doped graphene (NGr) for fabrication of Vit.B12-NGr nanohybrids; an electrochemically stable, reusable electrocatalyst with an excellent prospect for hydrogen evolution reaction (HER) and non-enzymatic electro-oxidative sensing of H2O2. Through the data recorded for the characterization of the Vit.B12-NGr nanohybrids through various techniques it shall be clearly proven that the conceived method ensures the self-assembling of Vitamin B12 as a monolayer over N-Gr. Results from our detailed voltammetric investigations over the Vit.B12-NGr modified electrodes besides establishing the redox accessibility, stability and enhanced activity of Co(II) centres in Vit.B12-NGr composites also suggest that the presence of NGr in Vit.B12-NGr composite not only assists the directed ET to Vit.B12, but it also improves the stability of the resulting composite by minimizing its loss to the solution phase.
Results from our electrocatalytic investigations clearly demonstrate the excellent stability and electrocatalytic activity of Vit.B12-NGr nanohybrid towards HER (Figure 1). For HER, the Vit.B12-NGr nanohybrid displays onset potential of -0.096 V vs RHE, a low Tafel slope of ca. 68.3 mV/dec and an overpotential requirement of just -0.210 V for 10 mAcm-2. Moreover, we shall present results from our electro-sensing investigation that establish that the Vit.B12-NGr is a promising electrocatalytic surface for the electro-oxidative sensing of H2O2. In our investigations we observed that use of Vit.B12-NGr ensures the H2O2 sensing with a sensitivity of 430 µA/mM (8.775 µAmM-1cm-2) and a limit of detection as low as 0.02 µM. These HER activity and H2O2 sensing parameters displayed by Vit.B12-NGr are either superior or comparable to those observed for the various recently reported state-of-the-art HER electrocatalysts and H2O2 sensors.

Figure 1.
HER performance at various electrodes
(A)
LSV polarization curves (negative direction) of bare-GCE (black line), NGr/GCE (red line), Vit.B12-NGr/GCE (blue line) and Pt/C (green dotted line)in 0.5 M H2SO4 with scan rate 100 mV/s.
(B)
The corresponding HER Tafel plot of NGr/GCE, Vit.B12-NGr/GCE and Pt/C.
(C)
LSV curves on Vit.B12-NGr/GCE surface at the ﬁrst cycle (black) and after 50 cycles (red dotted) (scan rate 100 mV/s).

Figure 1
Nuclear Activation Function 2 Estrogen Receptor α Attenuates Arterial and Renal Alterations Due to Aging and Hypertension in Female Mice
Authors: Guivarc'h Emmanuel , Favre Julie , Guihot Anne‐Laure , Vessières Emilie , Grimaud Linda , Proux Coralyne , Rivron Jordan , Barbelivien Agnès , Fassot Céline , Briet Marie , Lenfant Françoise , Fontaine Coralie , Loufrani Laurent , Arnal Jean‐François , Henrion Daniel 
Published: February 2020

Background
The cardiovascular protective effects of estrogens in premenopausal women depend mainly on estrogen receptor α (ERα). ERα activates nuclear gene transcription regulation and membrane‐initiated signaling. The latter plays a key role in estrogen‐dependent activation of endothelial NO synthase. The goal of the present work was to determine the respective roles of the 2 ERα activities in endothelial function and cardiac and kidney damage in young and old female mice with hypertension, which is a major risk factor in postmenopausal women.

Methods and Results

Five‐ and 18‐month‐old female mice lacking either ERα (ERα
−/−
), the nuclear activating function AF2 of ERα (AF2°), or membrane‐located ERα (C451A) were treated with angiotensin II (0.5 mg/kg per day) for 1 month. Systolic blood pressure, left ventricle weight, vascular reactivity, and kidney function were then assessed. Angiotensin II increased systolic blood pressure, ventricle weight, and vascular contractility in ERα
−/−
and AF2° mice more than in wild‐type and C451A mice, independent of age. In both the aorta and mesenteric resistance arteries, angiotensin II and aging reduced endothelium‐dependent relaxation in all groups, but this effect was more pronounced in ERα
−/−
and AF2° than in the wild‐type and C451A mice. Kidney inflammation and oxidative stress, as well as blood urea and creatinine levels, were also more pronounced in old hypertensive ERα
−/−
and AF2° than in old hypertensive wild‐type and C451A mice.

Conclusions
The nuclear ERα‐AF2 dependent function attenuates angiotensin II–dependent hypertension and protects target organs in aging mice, whereas membrane ERα signaling does not seem to play a role.
A Nest for Art and Science
Authors: Pérez-Gallego Jorge , Espelie Erin , Knight Tara 
Published: February 2020

Abstract
Forming part of the University of Colorado Boulder’s Grand Challenge initiative, the Nature, Environment, Science & Technology (NEST) Studio for the Arts is a new endeavor that explores the interrelation, generative overlaps and productive differences between the sciences and the arts by means of exhibitions, student work, lectures, panels, courses and events. Operationally launched in the summer of 2018, NEST seeks efforts that engage with central questions regarding alternative and constructive ways of passing information and methodologies back and forth between the two worlds. Efforts such as these are key to advancing cross-disciplinary efforts in siloed campuses across the nation.
Identity-Based Crossmodal Negative Priming: Aftereffects of Ignoring in One Sensory Modality on Responding to Another Sensory Modality
Authors: Wesslein Ann-Katrin , Frings Christian 
Published: February 2020

Abstract
Negative Priming (NP) refers to the phenomenon that responses towards previously ignored stimuli, as compared to new stimuli, are impaired. That is, NP is reflected in the performance on the probe display of a prime–probe sequence. NP is established in vision, audition and touch. In the current study, we presented participants with auditory, visual, and tactile manifestations of the same temporal patterns in order to measure NP across the senses. On each trial, the sensory modality shifted from the prime to the probe. Each prime and probe display consisted of a target and a distractor stimulus, presented to the same sensory modality. On some trials, the prime distractor repeated as probe target (ignored-repetition trials), on other trials the probe stimuli had not been involved in the prime display (control trials). We observed NP between audition and touch (Experiment 1) and between vision and audition (Experiment 2). These findings indicate that the processes underpinning NP can operate at an amodal, postperceptual level.
The impact of progesterone receptor expression on prognosis of patients with rapidly proliferating, hormone receptor-positive early breast cancer: a post hoc analysis of the IBIS 3 trial
Authors: Bravaccini Sara , Bronte Giuseppe , Scarpi Emanuela , Ravaioli Sara , Maltoni Roberta , Mangia Anita , Tumedei Maria Maddalena , Puccetti Maurizio , Serra Patrizia , Gianni Lorenzo , Amaducci Laura , Biglia Nicoletta , Bounous Valentina , Paradiso Angelo Virgilio , Silvestrini Rosella , Amadori Dino , Rocca Andrea 
Published: February 2020

Background: In the Italian Breast Cancer Intergroup Studies (IBIS) 3 phase III trial, we compared cyclophosphamide, methotrexate, 5-fluorouracil (CMF) alone to sequential epirubicin/CMF regimens in patients with rapidly proliferating early breast cancer (RPEBC). We performed a post hoc analysis in the subgroup of patients with hormone-receptor-positive RPEBC on the prognostic role of progesterone receptor (PgR) status. Methods: RPEBC was defined by thymidine labeling index (TLI) >3% or grade 3 or S-phase >10% or Ki67 >20%. We analyzed 466 patients with hormone-receptor-positive RPEBC receiving sequential epirubicin/CMF regimens followed by tamoxifen, and for whom the status of ER and PgR was available. Results: Considering both cut-off values of 10% and 20%, PgR expression was significantly associated with age, menopausal status, and ER expression; HER2 status was associated with PgR status only at a cutoff value of 20% PgR. Upon univariate analysis, tumor size, nodal status, and PgR were significantly associated with disease-free survival (DFS) and overall survival (OS), while age class and local treatment type were associated only with DFS. Patients with PgR <20% showed lower 5- and 10-year DFS [hazard ratio (HR) = 1.48; 95%CI: 1.01–2.18; p = 0.044] and OS (HR = 1.85; 95%CI: 1.08–3.19, p = 0.025) rates compared with patients with PgR ⩾20%. Upon multivariate analysis, only tumor size, nodal status, and PgR were independent prognostic factors. Conclusions: Our results highlight the independent prognostic relevance of PgR expression in patients with hormone-receptor-positive RPEBC treated with adjuvant chemotherapy and endocrine therapy, where the definition of prognostic subgroups is still a major need.
Radiological and clinical evaluation of synthetic reinforcement in arthroscopic repair of complete degenerative rotator cuff tears
Authors: Boyer Etienne , Gasse Nicolas , Mataillet Jérome , Obert Laurent , Gallinet David 
Published: February 2020

Background: Rotator cuff tear is the most common shoulder pathology in adults over 45 years of age. In most instances they are chronic and degenerative. The high rate of re- tears after primary repair has led to the use of reinforcement systems such as patches. The objective of this study was to evaluate the effectiveness of a synthetic poly-4-hydroxybutyrate (P4HB) reinforcement patch in arthroscopic repair of degenerative rotator cuff tears. Methods: sixty patients with degenerative, reducible, full thickness supraspinatus tear were repaired with an arthroscopic single-row technique with or without the BioFiber® reinforcement system (Wright medical). A clinical evaluation with measurement of active range of motion, calculation of Constant and Subjective Shoulder Value (SSV) scores and ultrasound evaluation of healing were performed one year postoperatively. Results: Thirty patients were treated with a patch and thirty others formed the control group without a patch. The postoperative adjusted Constant score was 102 % in the patch group (PG) and 101 % in the control group (CG) (P = 0.6670). The postoperative SSV score was 81% in the PG and 88% in the CG (P = 0.029). The ultrasound healing rate was better in the PG and there was no re-tear in this group (P = 0.049). Conclusion: The interposition of the P4HB BioFiber® patch does not seem to provide any added functional value despite the effectiveness in terms of healing in the repair of degenerative, reducible complete tear of the supraspinatus tendon.
The moderating role of entrepreneurship education in shaping entrepreneurial intentions
Authors: Shah Iqtidar A. , Amjed Sohail , Jaboob Said 
Published: February 2020

AbstractFew studies investigated the role of entrepreneurship education in students’ entrepreneurial intentions. These studies produced controversial results which invited the attention of researchers for further investigations. This paper examines the moderating role of entrepreneurship education on the predictive value of attitude, subjective norms and self-efficacy for entrepreneurial intentions. True Experimental Design (post-test-only control group design) is used to investigate the change in the nature and magnitude of the impact of independent variables (personal attitude, self-efficacy and subjective norms) on the dependent variable (intentions) using entrepreneurship education as a moderating variable. Data were collected from the treatment group (completed entrepreneurship course) and control group (not taken entrepreneurship course) from various higher education institutions in Oman. Total 500 questionnaires were distributed, out of which 204 filled questionnaires were received back in which 196 qualified as valid responses. Structural equation modeling was used to test hypotheses. The statistical relationship among the modeled variables was estimated using Partial Least Square method. The results revealed that attitude toward entrepreneurship, subjective norms and self-efficacy are the significant predictors of entrepreneurial intentions. However, entrepreneurship education moderates this relationship by strengthening the path coefficients of attitude toward entrepreneurship and self-efficacy. Same time it weakens the path coefficient of subjective norms.
The critique of psychiatry as we enter the third decade of the 21st century
Authors: Rashed Mohammed Abouelleil 
Published: February 2020

SummaryCritical psychiatry takes the position that ‘mental illness’ should not be reduced to ‘brain disease’. Here I consider whether this particular stance is outdated in light of more recent exchanges on reductionism, which consider questions raised by new mental health sciences that seek truly integrative and specific biopsychosocial models of illness.
Efficacy of High-Dose Chemotherapy and Three-Dimensional Conformal Radiation for Atypical Teratoid/Rhabdoid Tumor: A Report From the Children’s Oncology Group Trial ACNS0333
Authors: Reddy Alyssa T. , Strother Douglas R. , Judkins Alexander R. , Burger Peter C. , Pollack Ian F. , Krailo Mark D. , Buxton Allen B. , Williams-Hughes Chris , Fouladi Maryam , Mahajan Anita , Merchant Thomas E. , Ho Ben , Mazewski Claire M. , Lewis Victor A. , Gajjar Amar , Vezina Louis-Gilbert , Booth Timothy N. , Parsons Kerry W. , Poss Vicky L. , Zhou Tianni , Biegel Jaclyn A. , Huang Annie 
Published: February 2020

PURPOSE Atypical teratoid/rhabdoid tumor (AT/RT) is an aggressive, early-childhood brain tumor without standard effective treatment. To our knowledge, we conducted the first AT/RT-specific cooperative group trial, ACNS0333, to examine the efficacy and safety of intensive postoperative chemotherapy and focal radiation to treat AT/RT. PATIENTS AND METHODS Patients from birth to 22 years of age with AT/RT were eligible. After surgery, they received 2 courses of multiagent chemotherapy, followed by 3 courses of high-dose chemotherapy with peripheral blood stem cell rescue and involved-field radiation therapy. Timing of radiation was based on patient age and disease location and extent. Central testing of tumor and blood for SMARCB1 status was mandated. Tumor molecular subclassification was performed retrospectively. The primary analysis was event-free survival (EFS) for patients < 36 months of age compared with a cooperative groups’ historical cohort. Although accrual was based on the therapeutic question, potential prognostic factors, including age, tumor location, M stage, surgical resection, order of therapy, germline status, and molecular subtype, were explored. RESULTS Of 65 evaluable patients, 54 were < 36 months of age. ACNS0333 therapy significantly reduced the risk of EFS events in patients < 36 months of age compared with the historical cohort ( P < .0005; hazard rate, 0.43; 95% CI, 0.28 to 0.66). Four-year EFS and overall survival for the entire cohort were 37% (95% CI, 25% to 49%) and 43% (95% CI, 31% to 55%), respectively. Timing of radiation did not affect survival, and 91% of relapses occurred by 2 years from enrollment. Treatment-related deaths occurred in 4 patients. CONCLUSION The ACNS0333 regimen dramatically improved survival compared with historical therapies for patients with AT/RT. Clinical characteristics and molecular subgrouping suggest prognostic differences. ACNS0333 results lay a foundation on which to build future studies and incorporate testing of new therapeutic agents.
Cervical vertebral maturation assessment on lateral cephalometric radiographs using artificial intelligence: comparison of machine learning classifier models
Authors: Amasya Hakan , Yildirim Derya , Aydogan Turgay , Kemaloglu Nazan , Orhan Kaan 
Published: February 2020

Objectives: This study aimed to develop five different supervised machine learning (ML) classifier models using artificial intelligence (AI) techniques and to compare their performance for cervical vertebral maturation (CVM) analysis. A clinical decision support system (CDSS) was developed for more objective results. Methods: A total of 647 digital lateral cephalometric radiographs with visible C2, C3, C4 and C5 vertebrae were chosen. Newly developed software was used for manually labelling the samples, with the integrated CDSS developed by evaluation of 100 radiographs. On each radiograph, 26 points were marked, and the CDSS generated a suggestion according to the points and CVM analysis performed by the human observer. For each sample, 54 features were saved in text format and classified using logistic regression (LR), support vector machine, random forest, artificial neural network (ANN) and decision tree (DT) models. The weighted κ coefficient was used to evaluate the concordance of classification and expert visual evaluation results. Results: Among the CVM stage classifier models, the best result was achieved using the ANN model (κ = 0.926). Among cervical vertebrae morphology classifier models, the best result was achieved using the LR model (κ = 0.968) for the presence of concavity, and the DT model (κ = 0.949) for vertebral body shapes. Conclusions: This study has proposed ML models for CVM assessment on lateral cephalometric radiographs, which can be used for the prediction of cervical vertebrae morphology. Further studies should be done especially of forensic applications of AI models through CVM evaluations.
The benefits of raising awareness of lymphoedema among care home staff
Authors: Thomas Melanie , Morgan Karen , Humphreys Ioan , Hocking Karl , Jehu Diane 
Published: February 2020

Background: Patients with lymphoedema referred to a lymphoedema service from care homes in one health board area in Wales were often complex cases, with repeated cellulitis, a history of falls and other complications. A pilot project was initiated to develop education and raise awareness of lymphoedema among care home staff. Aims: To enable care staff to identify residents with lymphoedema, promote prompt referrals, raise the importance of skin care and exercise in the management of lymphoedema and estimate the likely costs from complications associated with lymphoedema. Methods: An education tool was developed and 47 care homes were asked to participate. A lymphoedema therapist carried out a scoping review of the residents. Results: Forty-four care homes agreed to participate in the project with 1216 education packs being issued to care home staff. Initial findings suggest that of the 960 residents reviewed, 262 had lymphoedema (27%); 4% suffered with frequent falls, 1% had wounds and 3% had recurrent cellulitis. Only 13% (35/262) of residents with lymphoedema were known to the local lymphoedema service. Of the 31 residents reporting cellulitis, 81% had lymphoedema; of the 11 residents identified with a wound, 100% had lymphoedema and of the 40 residents reporting falls, 70% had lymphoedema. Conclusion: This educational project has identified the value of raising awareness of lymphoedema within care homes.
Generational Reenactment: Participating in Historical Reenactment to Confront Post-Deportation Trauma
Authors: Dunn Austin Graham 
Published: February 2020

Abstract
The interpretation of trauma from memory, the belatedness of events, is important to a broader understanding of generational trauma and collective identity, especially in relation to the deportations at the core of Bisbee ’17 (2018), directed by Robert Greene. Affirming Grierson’s claim that “no construction of collective identity can entirely dispense with memory,” the use of memory and reenactment in Bisbee ’17 is a way to deconstruct the trauma that perforates the town of Bisbee following the Bisbee deportation of 1917 (112). Bisbee ’17 complicates the concept of participatory reenactment as a form of recovery, where “in these participatory reenactments, subjects use their words and bodies to both describe and perform their historical selves” (Fuhs 58). In the instance of Bisbee ’17, the deportation is reimagined through performance, the townsfolk playing historical characters that come to both represent themselves and the figures of the past – in the case of Mel and Steve Ray, this relationship is further complicated by their portrayal of ancestors involved in the deportation. Most notably, Greene’s use of Fernando Serrano, a young Mexican American, who is both directly and indirectly impacted by the Bisbee deportation – his own mother was deported back to Mexico – is an attempt to juxtapose past and present.
This Is How I Remember: The Beaches of Agnès, Documentary Narration, and Building a Self in Film
Authors: Jacobs Matthew 
Published: February 2020

Abstract

The Beaches of Agnès (Les plages d’Agnès, Varda, 2008) could be described as a film essay, a memoir, an autobiography, or categorized as a documentary; while each of these may be accurate, the film pushes at the edges of these terms, playing with ideas of truth, fictionality and methods of re-creation. There is a constant tension in the film between “La Varda” the legendary French New Wave filmmaker, Agnès Varda the human director, and Agnès Varda the subject of investigation. From a narrative theory standpoint, there is a constant tension between the Narrated-I (the Varda being investigated as a historical subject) and the Narrating-I (some combination of the Varda we see on-screen and the implied Varda-author). The documentary nature of the film, documentary being heavily dependent on ideas of authority, recreation, and facticity, is a concern for Varda as she plays with these conventions in her own recreations and playful fictionalizing. These efforts and effects all lead to an amount of purposeful distancing between the real Varda, the on-screen Varda, and the Varda in recreation. This distancing mirrors the construction of the “author” – “implied author” – “narrator” system: the author Varda (actually visible, perhaps, glimpsed in the acts of directing); the implied Varda-author (present in the final decisions we see in camerawork, framing, and story progression) (the implied author here also, curiously, is the subject of the film); and the character-narrator, the Varda who takes the viewer through the film. These complications of self and past provide an opportunity to examine the film’s narrative construction, in which different aspects of the same self are presented simultaneously but are being put to different purposes. These techniques are part of Agnès Varda’s larger desire to destabilize the center subject of the film and to mediate that destabilization in the film’s construction. Varda mirrors in the film’s construction the techniques she’s using to outline the image of herself as the film’s subject: using techniques of fictionality and conventions of narrative to build an assemblage film and assemblage subject. Varda produces an impression of her subject, an outline built as decentered assemblage, giving a portrait of herself in a new type of “modest” (Bonner 121) autobiography-documentary.
Film
Authors: Milowicki Cari , Michael Nick , Lee Rylan , Corbett Jack 
Published: February 2020

Abstract

Hieronymus Bosch, Touched by the Devil (2015)
Netherlands
Director Pieter van Huystee Runtime 86 minutes

In Jackson Heights (2015)
USA
Director Frederick Wiseman Runtime 190 minutes

Yours in Sisterhood (2018)
USA
Director Irene Lusztig Runtime 101 minutes

They Shall Not Grow Old (2018)
UK/New Zealand
Director Peter Jackson Runtime 99 minutes

Paragraph 175 (2000)
USA
Directors Rob Epstein and Jeffrey Friedman Runtime 81 minutes