bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Overall Trend of Headache Remission during COVID-19 Pandemic for Chinese Patients with Pre-existing Headache Highlights the Role of Family Supports
Authors: Gong Qiaoyu , Liu Shuping , Li Ruiting , Yao Lihua , xiao Zheman 
Published: October 2020

Abstract
Background: Impact of COVID-19 pandemic on Chinese patients with pre-existing headache remains unclear. The present study investigated the impact of COVID-19 pandemic on headache patients in China.Methods: A survey was conducted through an online survey platform from June 6, 2020. Demographic characteristics, PHQ-9 scores, ISI scores, COVID-19 questionnaires and headache profile section were included in the online questionnaires.Results: Eventually a total of 15,000 participants from China completed the online questionnaire. Among them, 2806 participants (18.71%) had preexisting headache disorders. Our analysis showed a reality of those participants with remission of headache duration (3.414±6.859 vs 4.033±7.325, P=0.000), headache days per month (1.788±2.989 vs 2.092±3.694, P=0.000), and headache intensity (4.110±1.609 vs 4.290±1.680, P=0.000), during COVID-19. Smoking (OR=1.397, 95% CI 1.090 to 1.790, P=0.008) and getting support from family members during the social isolation (OR=1.656, 95% CI 1.075 to 2.550, P=0.022) were the independent factors of remission in headache duration. Education level (OR=1.478, 95% CI 1.103 to 1.980, P=0.009) and having relative or acquaintance got COVID-19 (OR=0.643, 95% CI 0.458 to 0.902, P=0.011) were the independent factors of remission in headache severity. And participants living in Wuhan area, having COVID-19 symptoms or COVID-19 diagnosis and having relative or acquaintance got COVID-19 are more likely to get headache deteriorated.Conclusions: Participants presented an overall trend of headache remission during COVID-19. Family supports played an important role in headache remission.
Blink Synchronized Brain Activation: Association With Ascending Arousal Network
Authors: Demiral Şükrü Barış , Liu Christopher , Benveniste Helene , Tomasi Dardo , Volkow Nora 
Published: October 2020

Abstract
Eye-blinking has been implicated in arousal and attention. Here we test the hypothesis that, blinking-moments represent arousal transitions associated with activation of the ascending arousal network (AAN) and its thalamic projections. For this purpose, we explored the temporal relationship between eye-blinks and fMRI BOLD activity in the AAN and thalamus during a choice-reward task and an eyes-open resting state. We show that during the task, blinks were associated with activation of AAN and thalamic nuclei at the blink moment. During rest, peaks of AAN and thalamic nuclei were not synchronized and appeared weaker except for the ventral tegmental area (VTA). Our findings of an association between eye blinks and activation of the AAN and thalamus provides strong evidence in support of the role of eye blinking in arousal transitions that are influenced by cognitive states. It also corroborates the involvement of the dopaminergic VTA nucleus in eye blinking.
Entanglement and Bell Inequalities : No Correlation
Authors: Scarzafava Eugene 
Published: October 2020

Abstract
Claims that entanglement, or non-local interaction ("spooky action-at-a-distance), has been experimentally proven are false. The claims are based entirely on the fact that the results of experiments performed to test that issue (EPR-Bohm experiments) violate various theoretical inequalities (Bell Inequalities).The various Bell Inequalities used to interpret the results of EPR-Bohm experiments are shown to be inappropriate for such experiments. The inequalities do not correctly provide for the correlation between the particles in each pair, which is the essence of such experiments; and therefore the inequalities are irrelevant. Claims that the results of such experiments, because they violate the inequalities, require the conclusion that the measurement of one particle in an "entangled" pair can instantly affect the state of its partner, even at great distances, are untrue and need to be modified.
Evaluating the Therapeutic Potential and the Suitability of&nbsp;Neutron Beams Designed for Clinical BNCT
Authors: Postuma Ian , Gonzalez Sara , Herrera Maria , Provenzano Lucas , Ferrarini Michele , Magni Chiara , Protti Nicoletta , Setareh Fatemi , Vercesi Valerio , Battistoni Giuseppe , Tambur1ni Umberto Anselmi , Liu Yuan Hao , Kankaanranta Leena , Koivunoro Hanna , Altieri Saverio , Bortolussi Silva 
Published: October 2020

Abstract
The standard of neutron beam quality for Boron Neutron Capture Therapy (BNCT) of deep-seated tumours is currently deﬁned by its physical characteristics in air: the epithermal neutron ﬂux, the ratio of thermal and epithermal neutron ﬂux, the fast neutron and photon dose contamination, and the beam collimation. Traditionally, the beam design consists in tailoring a Beam Shaping Assembly (BSA) able to deliver a neutron beam with the recommended values of these ﬁgures of merit (FOMs). This work investigated the possibility to produce an epithermal neutron beam able to guarantee the best clinical performance for deep-seated tumours, starting from a 5 MeV, 30 mA proton beam coupled to a beryllium target. Diﬀerent Beam Shaping Assemblies were designed using those physical FOMs which, however, were not enough to establish a clear ranking of the diﬀerent beams, nor to describe their clinical relevance. To go beyond this traditional approach, beams were then evaluated employing new criteria based on the dose distributions obtained in-phantom and on the calculation of the Uncomplicated Tumour Control Probability (UTCP). Such radiobiological FOM allows establishing the therapeutic potential of the beams. Moreover, we included the concept of suitability as a criterion to select the safest BSA design, calculating the in-patient out-of-beam dosimetry. The clinical relevance of the selected beam was ﬁnally tested in the treatment planning of a clinical case treated at the FiR 1 beam in Finland, where several patients have safely and successfully received BNCT in the last years. Despite the selected beam does not comply with all the standard physical recommendations, it shows a therapeutic potential comparable and even better than that of FiR 1. This conﬁrms that establishing the performance of a beam cannot rely only on its physical characteristics, but requires additional criteria able to predict the clinical outcome of a BNCT treatment.
WITHDRAWN: A study of bladder filling consistency before and during the radiotherapy for pelvic cancer
Authors: Feng Xin , Chen Qianyi , Huang Sijuan , Wu Jiaying , Zheng Wanjia , Li Yaning , Li Junyun , Li Cunxiao , Chi Feng , Cao Xinping , Yang Xin 
Published: October 2020

Abstract
Background: The purpose of this study was to analyze the consistency of bladder filling before and during radiotherapy for pelvic cancer patients.Methods: Before radiotherapy, 105 patients followed a strict bladder protocol of consuming 540mL of water immediately after emptying the bladder. Bladderscan device BVI 9400 was used after emptying bladder and measured every 30 minutes until the bladder volume achieve 400mL. When emptying, half an hour and 1 hour after drinking, chief complaint of urgency, the actual bladder volume and corresponding time were described as: U0, t0; U0.5, t0.5; U1, t1; Ut, t; UT, T. During radiotherapy, 18 patients were randomly selected from 105 patients. They were instructed to keep the same pattern of suppressing urination during the following radiotherapy. The chief complaint of urgency during radiotherapy was observed and recorded. The relative bladder volume was as close as possible to (50%,155%).Results: Before radiotherapy, patients were no statistically difference between U1 (P=0.177) and UT (P=0.052) in the Immobilization, Simulation CT scan, X-ray Simulation. Bladder volume was concentrated at 298-526mL. There was no statistical difference between Ut and UT in X-ray Simulation(P=0.198). Patients emptied bladder volume for 75.2±49.9min, Ut=331.2±140.3mL. During radiotherapy, 18 (18/105) patients received a total of 450 bladder volume (18*25). UP and UT were statisticall different (P<0.05), and the difference was 17.81%. The overall relative bladder volume was negatively correlated with the number of radiotherapy (r = -0.5726, p = 0.0028) and the consistency rate was 82.89% (373/450). 15 patients (15/18) passed, and the consistency rate was 96% (360/375). 3 patients (3/18) failed, and the consistency rate was 17.33% (13/75). The consistency rate had no linear correlations with age (P = 0.2741). Conclusions: U1 was consistent in the Immobilization, Simulation CT scan, X-ray Simulation and during inter-fraction radiotherapy. This indicates that the consistency range is reasonable. Relative bladder volume between (50%,155%) can determine whether the bladder filling of patients with pelvic cancer is consistent with the planned bladder volume before radiotherapy.
Comparative Genomic and Phenotypic Analyses of Pathogenic Fungi Neoscytalidium Dimidiatum and Bipolaris Papendorfii, Isolated From Human Skin Scraping
Authors: Kuan Chee Sian , Ng Kee Peng , Yew Su Mei , Meleh Hadiza Umar , Seow Heng Fong , How Kang Nien , Yeo Siok Koon , Jee Jap Meng , Tan Yung-Chie , Yee Wai-Yan , Hoh Chee-Choong , Velayuthan Rukumani Devi , Na Shiang Ling , Masri Siti Norbaya , Chew Shu Yih , Than Leslie Thian Lung 
Published: October 2020

Abstract
Background: Neoscytalidium dimidiatum and Bipolaris species are fungal plant pathogens that have been reported to cause human diseases. Recently, we have isolated numerous N. dimidiatum and Bipolaris species from the skin scrapings and nails of different patients. In this work, we have sequenced the genome of one strain of N. dimidiatum. The sequenced genome was compared to that of a previously reported Bipolaris papendorfii genome for a better understanding of their complex lifestyle and broad host-range pathogenicity. Results: Their 33-43 Mb genomes include 11,015-12,320 putative coding DNA sequences, of which 0.51-2.49 are predicted transposable elements. Analysis of secondary metabolism gene clusters revealed several melanin biosynthetic genes and genes involved in fungal iron uptake. The arsenal of CAZymes related to plants pathogenicity is comparable between the species, including genes involved in hemicellulose and pectin decomposition. Several important genes-encoding keratinolytic peptidases were identified in N. dimidiatum and B. papendorfii, reflecting their potential pathogenic role in causing skin and nail infections. In this study, additional information on the metabolic features of these two species, such as nutritional profiling, pH tolerance, and osmotolerant are revealed. Conclusions: The genomic characterization of N. dimidiatum and B. papendorfii provides the basis for the future functional studies to gain further insights as to what makes these fungi persist in plants and why they are pathogenic to humans.
Bee's Honeys With High Concentration of Dicarbonyl Molecules Are Rich in Vitamin C and Deficient in Hydrogen Peroxide
Authors: ALaerjani Wed Mohammed Ali , Al-Musa Amal Ahmed Ali , Mohammed Mohammed Elimam 
Published: October 2020

Abstract
The altitude is well known to affect the temperature, parometric and oxygen pressure and the amount of UV radiation which affect the bees and the physicochemical properties of bee's honey. This study investigated the relations between the concentration of hydrogen peroxide, vitamin C and dicarbonyl molecules in honey samples from different floral origins and altitudes. Ten Ziziphus and twenty Acacia honey samples were collected directly from their bee farms. The hydrogen peroxide and vitamin C were measured using redox titartions while the dicarbonyl molecules concnetration was determined spectrophotometerically. The results were statisticaly analyzed by the ANOVA and t-test of the SPSS. The mean concentration of vitamin C in the Acacia and Ziziphus honey samples were 275.14± 82.3 and 239.16± 91.5 mg/100g, respectively. The mean hydrogen peroxide percentages in the Acacia and Ziziphus honey samples were 2.66± 0.81 and 4.94± 1.85%, respectively. The mean concentrations of the dicarbonyl molecules in the Acacia and Ziziphus were 324.62± 291.03 and 115.75± 94.9 mg/Kg, respectively. Significant variations were reported in the case of the hydrogen peroxide and the dicarbonyl molecules concentrations in the Acacia and Ziziphus honeys (p- values = 0.004 and 0.007, respectively). The altitude significantly afected the studied parameters. Honeys rich in dicarbonyl molecules have a high concentration of vitamin C and low content of hydrogen peroxide.
Thyroid Nodules with Preoperative Benign Cytology and BRAF V600E Mutations: the Role of Conventional Ultrasound and Shear Wave Elastography
Authors: Zhang Ying , Lu Feng , Zhang Yi-Feng , Wang Han-Xiang , Hui Shi , Guo Le-Hang , Wei Qing , Sun Xue-Chen 
Published: October 2020

Abstract
Objectives: Ultrasound-guided fine-needle aspiration (FNA) is the most accurate and economical means for the differential diagnosis of thyroid nodules, but false negative results also existed. This study aimed to predict the false negative results of FNA, reduce the missed diagnosis and improve the current management strategy of thyroid nodules. Methods: A total of 1232 consecutive patients with thyroid nodules who received FNA and BRAF V600E detection were adopted. All patients received both CUS (conventional ultrasound) and SWE (shear wave elastography) examinations and characteristics of these thyroid nodules were analyzed to evaluated the diagnostic performances of risk factors for malignancy.Results: Finally, 26 nodules with benign cytology and BRAF V600E mutations were enrolled. Undefined boundary, microcalcification and E max ratio > 1.49 were risk factors for malignancy (P<0.05), and the area under the receiver operating curve (ROC) of above CUS features and elastic value were 0.817 (95% CI: 0.617, 0.940), 0.792 (95% CI: 0.588, 0.925) and 0.792 (95% CI: 0.617, 0.940) respectively. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were 80.0%, 83.3%, 94.1%, 55.6% and 80.7% for undefined boundary, 75.0%, 83.3%, 93.8%, 50.0% and 76.9% for microcalcification and 75.0%, 83.3%, 93.8%, 50.0% and 76.9% for E max ratio > 1.49 respectively. There was no difference between benign and malignant nodules in the patient age, sex and nodule sizes (P>0.05).Conclusions: Undefined boundary, microcalcification and E max ratio > 1.49 were risk factors for malignancy in benign cytology nodules. When FNA results were benign but above characteristics could be found in the thyroid nodules with BRAF V600E mutation, further clinical decisions should be carried out to reduce the missed diagnosis.
In silico Investigation of Saponins and Tannins as Potential Inhibitors of SARS-CoV-2 main Protease (Mpro)
Authors: Falade Victoria Adeola , Adelusi Temitope Isaac , Adedotun Ibrahim Olaide , Abdul-Hammed Misbaudeen , Lawal Teslim Alabi , Agboluaje Saheed Alabi 
Published: October 2020

Abstract
It is no longer news that a novel strain of coronavirus named SARS-CoV-2 is ravaging the health sector worldwide, several attempts have been made to curtail this pandemic via repurposing of old drugs but at the present, available drugs are not adequately effective. Over the year, plant phytochemicals are increasingly becoming an alternative source of an antimicrobial agent with a novel mechanism of action and limited side effects compared to synthetic drugs. Isolated saponins and tannins were evaluated for antiviral activity against SARS-CoV-2 Mpro via Molecular Docking and it was observed that a handsome number of the phytochemicals had binding affinity much better than Remdesivir, Dexamethasone, and N3 inhibitor which were used as the standard in this study. Further Investigation of drug-likeness, ADMET profile, and bioactivity of these phytochemicals revealed that binding affinity alone is not enough in the drug discovery process and that 4 hit compounds were identified as potential inhibitors of SARS-CoV-2Mpro. This preliminary study furnishes Ellagic acid, Arjunic acid, Theasapogenol B, and Euscaphic acid as potential inhibitors of SARS-CoV-2 Mpro with better pharmacokinetics and bioavailability compared to Remdesivir which is currently used compassionately.
Lobectomy Versus Segmentectomy in Patients with Stage T (&gt;2 cm and ≤3 cm) N0M0 Non-small Cell Lung Cancer: A Propensity Score Matching Study
Authors: Wang Linlin , Ge Lihui , Zhang Guofeng , Ren Yi , Liu Yongyu 
Published: October 2020

Abstract
Background: Whether lung segmentectomy is a safe and effective surgical treatment in patients with early non-small cell lung cancer (NSCLC) remains controversial. We have therefore reviewed the clinicopathologic characteristics and survival outcomes of patients receiving a lobectomy vs. segmentectomy to treat early T (>2 cm and ≤3 cm) N0M0 NSCLC.Methods: We obtained data from the Surveillance, Epidemiology, and End Results (SEER) database for patients who underwent lobectomy or segmentectomy between 2004 and 2015. To reduce bias and imbalance between the treatment groups, propensity score matching (PSM) analysis was performed. We used Kaplan-Meier curves to estimate overall survival (OS) and lung cancer-speciﬁc survival (LCSS), performed univariate and multivariate Cox proportional hazards regression analyses to identify independent prognostic factors for OS and CSS, and applied the Cox proportional hazards model to create forest plots. Results: A total of 5783 patients from the SEER database were included. Of these, 5531 patients underwent lobectomy, and 252 patients underwent segmentectomy. Before matching, both univariate and multivariate Cox regression analyses showed that patients who underwent lobectomy had better OS (hazard ratio [HR]: 1.561; 95% confidence interval [CI] 1.292-1.885; P <0.001) and LCSS (HR: 1.551; 95% CI 1.198-2.009; P=0.001) than patients who underwent segmentectomy. However, survival differences between the groups were not significant; OS (P=0.160) and LCSS (P=0.097) after matching. Regression analyses revealed that age, sex, lymph node dissection, and grade were independent predictors of OS and LCSS (P <0.05).Conclusions: For patients with stage T (>2 cm and ≤3 cm) N0M0 non-small cell lung cancer, segmentectomy can achieve the same OS and LCSS compared with lobectomy. A large number of patients require further long-term follow-up analyses.
Identification of a Circulating miRNA Signature to Stratify Acute Respiratory Distress Syndrome Patients
Authors: Martucci Gennaro , Arcadipane Antonio , Tuzzolino Fabio , Occhipinti Giovanna , Panarello Giovanna , Carcione Claudia , Bonicolini Eleonora , Vitiello Chiara , martino lavinia , Lorusso Roberto , Conaldi Pier Giulio , Miceli Vitale 
Published: October 2020

Abstract

Background Acute respiratory distress syndrome (ARDS) is a clinical definition of a inflammatory lung disease comprising a heterogeneous group of causes. Despite the fact that veno-venous extracorporeal membrane oxygenation (V-V ECMO) may efficaciously support the most severe cases of ARDS, the mortality is still high. There is a need to improve both ARDS diagnosis and clinical management, particularly with ECMO, and different biomarkers have been tested to implement a precision-focused approach. Methods We included 11 ARDS patients treated with V-V ECMO in a prospective observational pilot study. Clinical baseline, main ECMO management, and outcome-related data were collected. Blood samples were obtained before cannulation, and screened for the expression of 754 circulating microRNA (miRNAs) using high-throughput qPCR. A hierarchical cluster analysis was applied to allow grouping of patients with similar expression patterns. The miRNet database was used to predict target genes of deregulated miRNAs, and the DIANA tool was used to identify significant enrichment pathways, while logistic regression was used to determine the area under the curve (AUC) for associations between miRNA expression and ARDS severity.Results A hierarchical cluster of 229 miRNAs (identified after quality control screening) produced a clear separation of patients into two groups: considering the baseline SAPS II, SOFA and RESP score, cluster A (n=6) showed higher severity compared to cluster B (n=5); all p values<0.05. After analysis of differentially expressed miRNAs between the two clusters, 95 deregulated miRNAs were identified and reduced to 13 by in silico analysis. These miRNAs (miR-93, 92a, -769, -99a, -212, -20a, -19b, -18a, -17, -126, -106b, -19a and let-7a) target genes implicated in tissue remodeling, immune system and blood coagulation pathways; the AUCs were 0.86, 0.90, 0.86, 0.93, 0.90, 0.93, 0.93, 0.88, 0.96, 0.90, 0.80, 0.93 and 0.86, respectively (all p value<0.01).Conclusions This pilot study shows that the blood levels of 13 miRNAs strongly related to biological pathways possibly associated with ARDS are altered in patients with severe ARDS, and may offer diagnostic value as well as contribute to ARDS stratification. Further investigations will have to match miRNA results with inflammatory biomarkers and clinical data to confirm these preliminary observations.
Are the thermodynamic properties of natural and synthetic Mg2SiO4-Fe2SiO4 olivines the same?
Authors: Geiger Charles A. , Vielreicher Noreen M. , Dachs Edgar 
Published: October 2020

Abstract
It is not known if the thermodynamic behavior of some minerals and their synthetic analogues are quantitatively the same. Olivine is an important rock-forming substitutional solid solution consisting of the two end-members forsterite, Mg2SiO4, and fayalite, Fe2SiO4. We undertook the first heat capacity, CP, measurements on two natural olivines between 2 and 300 K; nearly end-member fayalite and a forsterite-rich crystal Fo0.904Fa0.096. Their CP(T) behavior is compared to that of synthetic crystals of similar composition, as found in the literature. The two natural olivines are characterized by X-ray powder diffraction and 57Fe Mössbauer spectroscopy. The X-ray results show that the crystals are well crystalline. The Mössbauer hyperfine parameters, obtained from a fit with two Fe2+ quadrupole split doublets, are similar to published values measured on synthetic olivines. There are slight differences in the absorption line widths (i.e., FWHM) between the natural and synthetic crystals. CP (2 to 300 K) is measured by relaxation calorimetry. The CP results of the natural nearly end-member fayalite and published values for two different synthetic Fa100 samples are in excellent agreement. Even CP resulting from a Schottky anomaly and a paramagnetic-antiferromagnetic phase transition with both arising from Fe2+ are similar. There are slight differences in the Néel temperature between the natural 63 K and synthetic ~65 K fayalites. This is probably related to the presence of certain minor elements (e.g., Mn2+) in the natural crystal. The third-law entropy, S°, value is 151.6 ± 1.1 J/(mol·K). CP behavior of the natural forsterite, Fo0.904Fa0.096, and a synthetic olivine, Fo90Fa10, are in excellent agreement between about 7 and 300 K. The only difference lies at T &lt; 7 K, as the former does not show Debye T3 behavior, but, instead, a plateauing of CP values. The S° value for the natural forsterite is 99.1 ± 0.7 J/(mol·K).