bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep Learning Approach for COVID-19 Diagnosis Using X-Ray Images﻿
Authors: Al-Asfoor Muntasir 
Published: May 2020

Abstract
During the times of pandemics, faster diagnosis plays a key role in the response efforts to contain the disease as well as reducing its spread. Computer-aided detection would save time and increase the quality of diagnosis in comparison with manual human diagnosis. Artificial Intelligence (AI) through deep learning is considered as a reliable method to design such systems. In this research paper, an AI based diagnosis approach has been suggested to tackle the COVID-19 pandemic. The proposed system employs a deep learning algorithm on chest x-ray images to detect the infected subjects. An enhanced Convolutional Neural Network (CNN) architecture has been designed with 22 layers which is then trained over a chest x-ray dataset. More after, a classification component has been introduced to classify the x-ray images into two categories (Covid-19 and not Covid-19) of infection. The system has been evaluated through a series of observations and experimentation. The experimental results have shown a promising performance in terms of accuracy. The system has diagnosed Covid-19 with accuracy of 95.7% and normal subjects with accuracy of 93.1 while it showed 96.7 accuracy on Pneumonia.
Spectrophotometric Methodologies Applied for Determination of Pharmaceuticals
Authors: Cini Nejla , Gölcü Ayşegül 
Published: May 2020

Background:
The development of innovative approaches in drug analysis is a challenging
task for medicine, pharmacy, and engineering sciences. For instance, the requirement of proper dosage
forms in releasing active ingredients is crucial. It is essential to analyze drugs in biological liquids
for early diagnosis and treatment purposes. Drug analysis is also of great importance to control
the quality of pharmaceutical products, test their efficacy, and develop novel drug formulation. The
present review is aimed to highlight the most recent spectrophotometric approaches applied to analyze
various classes of drugs in biological media and/or dosage forms.

Methods:
Direct and derivative UV/UV-Vis spectrophotometry and a combination of various techniques
with spectrophotometry, such as injection analysis and chemometrics, have most widely been
applied in the analysis of dosage forms. In addition, emerging technologies, such as UV imaging allows
to obtain the distribution of drug concentration in time-resolved 2D images based on UV light
absorption, utilization of nanotechnology, self-assembled nanomaterials, and aptamer-based nanoparticles
have gained interests to investigate drug assays and to quantify the proper drug release.

Results:
Due to their high versatility, ease of application, low cost, and fast response, spectrophotometric
methods are one of the most preferable methods providing high accuracy and precision with a
wide linear range in drug analysis.

Conclusion:
Selected examples demonstrating the applicability of spectrophotometric methods in
pharmaceutical assays in this review might contribute to the overall importance of the analytical test
used in modern pharmaceutical analysis.
Co-Administration of Soluble Fibres and Lactobacillus casei NCDC19 Fermented Milk Prevents Adiposity and Insulin Resistance Via Modulation of Lipid Mobilization Genes in Diet-Induced Obese Mice
Authors: Jangra Surender , Pothuraju Ramesh , Sharma Raj K. , Bhakri Gaurav 
Published: May 2020

Background:
Numerous reports explaining the beneficial health effects of soluble fibres and
probiotics on lifestyle disorders have been published. However, a little information is available on coadministration
of soluble fibres such as gum acacia & inulin and probiotic lactobacilli. Therefore, in
the present study, we have evaluated the synergistic effects of soluble fibres and probiotic fermented
milk on adiposity, insulin resistance and dyslipidemia in C57BL/6 mice fed high-fat and sucrose diet
for 18 weeks.

Objective:
To explore the synergistic effect of soluble fibres (gum acacia/inulin) and Lactobacillus
casei NCDC19 fermented milk on adiposity, insulin resistance and lipid mobilization genes in dietinduced
obese mice.

Methods:
C57BL/6 mice were divided randomly into three groups (n = 9/group) according to their
body weights. The HFS group was fed high-fat and sucrose diet, the HFS-GFM group was fed HFS
diet incorporated with gum acacia (7%, w/w) along with L. casei NCDC19 fermented milk and HFSIFM
group was fed HFS diet incorporated with inulin (7%, w/w) along with L. casei NCDC19 fermented
milk.

Results:
At the end of the experiment, final body weight, epididymal fat (E.fat) weight, and adipocyte
size were found to be lower in groups received either gum acacia or inulin in combination with L. casei
NCDC19 fermented milk (HFS-GFM or HFS-IFM). Also, fasting blood glucose, serum insulin,
triglycerides, and VLDL-cholesterol levels were decreased significantly in both HFS-GFM and HFSIFM
fed groups. Furthermore, relative mRNA expression of genes (cpt1, foxa2, pgc1β, and pparα)
related to fatty acid oxidation enhanced significantly in the liver. In E.fat pad, expression of adiponectin
was upregulated, whereas, leptin expression was reduced considerably. Also, expression of
fasting-induced adipose factor enhanced significantly in the distal ileum of mice in HFS-GFM and
HFS-IFM groups.

Conclusion:
Overall, we demonstrate that co-administration of soluble fibres viz. gum acacia, inulin
and L. casei NCDC19 fermented milk exhibited the anti-adiposity effects, improved insulin sensitivity
and dyslipidemia in mice via modulation of lipid mobilization genes.
Embedding the Pillars of Quality in Health Information Technology Solutions Using “Integrated Patient Journey Mapping” (IPJM): Case Study
Authors: McCarthy Stephen , O'Raghallaigh Paidi , Woodworth Simon , Lim Yoke Yin , Kenny Louise C , Adam Frédéric 
Published: May 2020

Background
Health information technology (HIT) and associated data analytics offer significant opportunities for tackling some of the more complex challenges currently facing the health care sector. However, to deliver robust health care service improvements, it is essential that HIT solutions be designed by parallelly considering the 3 core pillars of health care quality: clinical effectiveness, patient safety, and patient experience. This requires multidisciplinary teams to design interventions that both adhere to medical protocols and achieve the tripartite goals of effectiveness, safety, and experience.

Objective
In this paper, we present a design tool called Integrated Patient Journey Mapping (IPJM) that was developed to assist multidisciplinary teams in designing effective HIT solutions to address the 3 core pillars of health care quality. IPJM is intended to support the analysis of requirements as well as to promote empathy and the emergence of shared commitment and understanding among multidisciplinary teams.

Methods
A 6-month, in-depth case study was conducted to derive findings on the use of IPJM during Learning to Evaluate Blood Pressure at Home (LEANBH), a connected health project that developed an HIT solution for the perinatal health context. Data were collected from over 700 hours of participant observations and 10 semistructured interviews.

Results
The findings indicate that IPJM offered a constructive tool for multidisciplinary teams to work together in designing an HIT solution, through mapping the physical and emotional journey of patients for both the current service and the proposed connected health service. This allowed team members to consider the goals, tasks, constraints, and actors involved in the delivery of this journey and to capture requirements for the digital touchpoints of the connected health service.

Conclusions
Overall, IPJM facilitates the design and implementation of complex HITs that require multidisciplinary participation.
Las tecnologías de la información y la comunicación: una herramienta estratégica para el desarrollo académico y profesoral
Authors: Peñaranda Peñaranda Marta Milena , Bayona Trigos Ramón Armando , Manzano Durán Omaira 
Published: May 2020

En el presente artículo se pretende demostrar la importancia y la necesidad de la aplicabilidad de las llamadas tics, como herramienta de desarrollo académico que fomenten la creatividad y el cambio, en los diferentes entornos educativos y sus instituciones, ya que de esta forma los ambientes tecnológicos, la virtualidad y los procesos interactivos, han demostrado una mayor receptividad e interés en los estudiantes y docentes, debido al crecimiento de estas tendencias actuales, donde las comunidades digitales, las redes sociales, las aplicaciones, los buscadores, entre otras, se han convertido en un proceso de interacción, no solo del conocimiento y la ciencia, si no, en el intercambio de carácter cultural, social y humanístico, buscando la transformación de la sociedad y su entorno. Para este estudio se utilizó un enfoque metodológico cuantitativo que permitió analizar las competencias de los docentes y el uso de las TIC aplicadas en el aula de clases en el desarrollo de la estrategia pedagógica Dossier Formativo Integrador del programa de Contaduría Pública de la Universidad Francisco de Paula Santander de Ocaña (N. de S.), cuya unidad de análisis y estudio se realizó con los 57 docentes del programa, quienes han implementado la estrategia pedagógica en el aula de clases. Dentro de la estructura de análisis y diagnóstico de la información, se establecieron cuatro variables relacionadas con: Competencia de los docentes en el uso de las TIC, recursos tecnológicos utilizados en el aula de clases, tipo de acceso que tienen los docentes a las herramientas TIC en sus clases y nivel de integración de las TIC en el desarrollo de la estrategia pedagógica. Adicionalmente se establecieron las respectivas discusiones y posiciones de los autores frente a los resultados obtenidos en la investigación.
Teletrabajo como estrategia de empleabilidad para población con discapacidad
Authors: Callejas B. Harold J. , Gómez R. Sandra I. , Uriibe M. Sandra L. , Vergel V. Laura C. 
Published: May 2020

En Colombia, la inclusión laboral es un tema que se ha tratado en diferentes espacios de interés social. Para el año 2011 Según informe Mundial sobre la Discapacidad se hablaba de más de 1.000 millones de personas con alguna discapacidad y es de suponer que el acceso al trabajo se reduce debido a esta situación. MinSalud (2017) Según cifras del DANE en Colombia, 6.4% de los ciudadanos tiene algún tipo de discapacidad, el 52% en edad de trabajar y solo el 15% de ellos laboran. (CONFANDI, 2015).
El Teletrabajo como modalidad laboral permite cumplir con dos esquemas: contratación laboral estable e inclusión laboral de personas en condición de discapacidad. Además de evitar su desplazamiento, el trabajo desde casa es una opción ideal para el trabajador discapacitado ya que la mayoría cuenta con espacios físicos en su vivienda adaptados para sus necesidades; y para las empresas contratantes ya que les alivia los requerimientos de adecuación en sus instalaciones en las áreas de circulación y en los servicios sanitarios entre otros.
Se esperaría así una alta utilización de este estilo de trabajo por parte de trabajadores con discapacidad, sin embargo en este estudio realizado el porcentaje de discapacitados es similar al descrito en el trabajo convencional, por lo que valdría la pena incentivar más el teletrabajo entre las empresas y en la población discapacitada. (Uribe S, 2017)
Diagnóstico y tratamiento oportunos en la prevención de complicaciones cardiovasculadores de la enfermedad de Kawasaki, hospital de niños Roberto Gilbert Elizalde, enero 2005 hasta diciembre 2011
Authors: Castillo Higgins Maria Veronica , Armijos Villacís María Alejandra , Patiño Armijos Andrea , Salcedo Velarde Isabel María 
Published: May 2020

Introducción: la enfermedad de Kawasaki es una arteritis de vasos de pequeño y mediano calibre, la cual afecta en su gran mayoría a pacientes pediátricos y se considera como causa principal de cardiopatía adquirida en niños. Objetivo: relacionar el tipo de tratamiento (oportuno vs. no oportuno) con la presentación de complicaciones cardiovasculares en pacientes diagnosticados con enfermedad de Kawasaki. Métodos: estudio observacional, analítico, transversal, retrospectivo, donde se revisaron las historias clínicas de los pacientes con diagnóstico de enfermedad de Kawasaki en el hospital de niños Roberto Gilbert Elizalde, desde enero de 2005 a diciembre de 2011. Los criterios de inclusión fueron pacientes con diagnóstico de enfermedad de Kawasaki, edad entre 0 y 17 años y que cuenten con informes ecocardiográficos. Se excluyeron pacientes con cardiopatía previa, ya sea congénita o adquirida, que hayan presentado otros posibles focos infecciosos y también aquellos con historias clínicas incompletas. Resultados: la muestra total de pacientes que cumplieron los criterios de inclusión fue de 42. De ellos, 29 pacientes (69%) fueron de sexo masculino y el promedio de edad fue de 1.94 años. Según la combinación del tiempo de diagnóstico y tratamiento dado se dividió a los pacientes en dos grupos. El grupo de tratamiento oportuno, grupo 1 fue de 19 pacientes (45.2%), y el grupo de tratamiento no oportuno, grupo 2, fue de 23 pacientes (54.7%). En el Grupo 2 se encontró una diferencia estadísticamente significativa en el número total de pacientes que presentaron cualquier tipo de complicaciones cardiovasculares (p<0.001), pacientes con dilatación aneurismática (p 0.001), y con derrame pericárdico (p 0.002). Conclusión: las complicaciones cardiovasculares de la enfermedad de Kawasaki están relacionadas al diagnóstico y tratamiento inoportunos, tardíos e inapropiados, por lo que son necesarios mayores esfuerzos educativos acerca de la enfermedad y su detección para el personal médico y padres o cuidadores primarios.
New markers of human cumulus oophorus cells cultured in vitro – transcriptomic profile
Authors: Brązert Maciej , Kranc Wiesława , Jopek Karol , Kempisty Bartosz , Pawelczyk Leszek 
Published: May 2020

Abstract
The presence of CCs around the oocyte after ovulation is one of the key elements contributing to oocyte developmental competence. In the presented study, we used CCs from 12 patients aged 18-40 diagnosed with infertility. After harvesting cells on day 1, 7, 15 and 30 of culture, total RNA was isolated and transcriptomic analysis was performed. The DAVID software indicated the following GO BP terms: “cell junction organization”, “cell migration”, “cell morphogenesis involved in differentiation”, “cell morphogenesis” and “cell motility”. Of the genes belonging to all ontological groups, the most downregulated were: SLC7A8, DFNB31, COL1A1, CDC42SE1, TGFBR3, HMGB1, with the most upregulated genes being: ANXA3, KIAA1199, HTR2B, VCAM1, DKK1.
While many studies focus on attempts to obtain fully competent oocytes, scientists still have difficulty attaining adequate results in vitro. Lack of adequate knowledge often results in low in vitro fertilization efficiency. Therefore, our research focuses on CCs cells, thanks to which the oocyte most likely acquires developmental competence. The main purpose of the study was to identify the potential molecular markers responsible for cell junction organization, migration, differentiation, morphogenesis and motility.

Running title: New markers of human cumulus oophorus cells cultured in vitro
Modulatory effects of perindopril on cisplatin-induced nephrotoxicity in mice: Implication of inflammatory cytokines and caspase-3 mediated apoptosis
Authors: Aljuhani Naif , Ismail Raed S. , El-Awady Mohammed S. , Hassan Memy H. 
Published: May 2020

Abstract
Cisplatin-induced nephrotoxicity limits its anticancer effectiveness, thus this study’s aim was to assess the potential modulatory effect of perindopril on cisplatin-induced nephrotoxicity and to elucidate the possible underlying mechanisms. Renal dysfunction was induced in mice by a single injection of cisplatin (10 mg kg−1, i.p.) and perindopril was administered orally (2 mg kg−1, once daily) for 5 days. Perindopril remarkably ameliorated cisplatin-induced perturbations in renal histology, renal levels of tumor necrosis factor-alpha, interleukin-6 and interleukin-10, apoptosis-regulating protein expressions (Bax and Bcl2), and partially normalized Bax to Bcl2 ratio and active caspase 3 protein expression. Conversely, perindopril had no significant effect on cisplatin-induced elevations in serum creatinine and urea, microalbuminuria, kidney to body weight ratio, lipid peroxidation marker, superoxide dismutase and catalase activities and reduced glutathione content. In conclusion, perindopril may be safely used with cisplatin in mice since it ameliorated cisplatin-induced histopathological changes, inflammation and apoptosis without affecting renal biomarkers or oxidative stress.
Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as possible anticancer agents
Authors: Çevik Ulviye Acar , Osmaniye Derya , Levent Serkan , Sağlik Begüm Nurpelin , Çavuşoğlu Betül Kaya , Karaduman Abdullah Burak , Özkay Yusuf , Kaplancikli Zafer Asim 
Published: May 2020

Abstract
The synthesis of new N-(5-substituted-1,3,4-thiadiazol-2-yl)-2-[(5-(substituted amino)-1,3,4-thiadiazol-2-yl)thio]acetamide derivatives and investigation of their anticancer activities were the aims of this work. All the new compounds’ structures were elucidated by elemental analyses, IR, 1H NMR, 13C NMR and MS spectral data. Anticancer activity studies of the compounds were evaluated against MCF-7 and A549 tumor cell lines. In addition, with the purpose of determining the selectivity of cytotoxic activities, the most active compound was screened against a noncancer NIH3T3 cell line (mouse embryonic fibroblast cells). Among the tested compounds, compound 4y (N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-((5-(p-tolylamino)-1,3,4-thiadiazol-2-yl)thio)acetamide), showed promising cytotoxic activity against MCF7 cancer cell with an IC
50value of 0.084 ± 0.020 mmol L−1 and against A549 cancer cell with IC
50 value of 0.034 ± 0.008 mmol L−1, compared with cisplatin. The aromatase inhibitory activity was evaluated for compound 4y on MCF-7 cell line showing promising activity with IC
50 of 0.062 ± 0.004 mmol L−1.
The Physical Conditions in Educational Institutions and their Relationship with the Teaching Performance in High Schools
Authors: Mohamed M. Bensabeur , Djamel M. Mokrani , Brahim M. Harbech 
Published: May 2020

Summary
The purpose of this research is to determine the nature of the relationship between the physical conditions and the teaching performance of the teacher of physical education and sport in high schools of Mostaganem (Algeria). To achieve the objectives of the study, the researchers prepared two main questionnaires. The first questionnaire was about the school physical conditions whereas the second was related to the teaching performance. These questionnaires were applied on a random sample that contains 65 teachers across high school level in Mostaganem, using the descriptive correlative approach. Thus, the results revealed there is a positive correlative relation between the physical conditions and teaching performance.
Wheelchair Push Up as a Powerful Exercises to Intensify Upper-Body Strength and Endurance Among Ectomorph Students
Authors: Zerf Mohammed , Taleb Allali , Benkhaled Hadj , Mokkedes Moulay Idriss , Ali Bengoua 
Published: May 2020

Summary
Ectomorph often below the average weight characteristics by a “thin frame” and difficult to gain muscle mass and fat. According to similar studies to build their muscle mass under it is necessary to include adequate multiple joints and larger muscle groups in bodybuilding program, in this study by using a wheelchairs, when doing a pushed up. The aim of the study was to improve upper-body strength and endurance among 20 healthy ectomorph male students, selected by the intentional method, according to their weight, which did not correspond to their height. They were controlled while performing push-ups, flexed arm-hangs and chin ups. Our goal was to compare the impacts of two training proposed programs (Traditional with weight (CS) v’s wheelchair (ES)). The training programs were applied for 6-weeks with 15-minute warm-ups integrated through their regular PE basketball courses cycle planned in the second semester. Built on statistical apply, we confirmed that wheelchair is a tool that enhances the upper-body muscles of ectomorph-type better than traditional body-weight training. It was approved in the present study through the use of wheelchair push-up, as an excellent means to increase the upper-body muscle-building strength and endurance better than the classic method used by our PE teachers.
Right Atrium Volume Index in Non-Severe Chronic Obstructive Pulmonary Disease
Authors: Cherneva Zh. , Denchev S. , Cherneva R. 
Published: May 2020

Abstract

Introduction: Right atrium volume index (RAVI) has recently been reported as a quantitative echocardiographic parameter associated with right ventricular systolic dys-function (RVSD) in patients with pulmonary arterial hypertension (PAH) due to chronic obstructive pulmonary disease (COPD).

Aims: The aim of the current study was to assess right atrium remodeling (RAVI) in COPD patients without echocardiographic parameters of RVSD or PAH at rest and to analyse its association with right ventricular diastolic dysfunction (RVDD) at rest and after exercise – stress-induced RVDD.

Methods: The study was conducted in 104 COPD patients. Pulmonary function tests, blood gas analysis, incremental, symptom-limited cardio-pulmonary test (CPET) protocol and detailed echocardiographic examinations before and 2-3 minutes after peak CPET were applied. The cut-offvalues for stress-induced RVDD were E/e’ > 6.0.

Results: Patients were divided into two groups: patients with stress-induced RVDD (82/104 – 78%) and those without stress-RVDD (22/104 – 22%). RAVI was significantly higher in the group with stress-induced RVDD (23,04 ± 2,67 ml/m2 vs 18,02 ± 2,69 ml/m2) in comparison to those without it. Correlation analysis showed that RAVI was associated with stress-induced RVDD (E/e’) and the distance from the 6 minute walk test (6-MWT), but was not an independent predictor for any of them.

Conclusions: RAVI correlates with stress-induced RVDD parameters (E/e’) in non-severe COPD patients without pulmonary arterial hypertension at rest. It corresponds to the diminished distance from the 6-MWT, but was not an independent factor of reduced physical activity.
Distribution and Epidemiological Aspects Associated with Enteric Bacterial Infections in Bulgaria
Authors: Mitova Y. , Doicheva V. , Angelova S. , Chumak N. 
Published: May 2020

Abstract
Enteric bacterial infections are characterized by the location of causative agents in the intestine and their distribution in the environment with excrements. Intestinal bacterial infections in Bulgaria are caused by Salmonella spp., Shigella spp., E. coli, Campilobacter spp., Yesinia enterocolitica. For the period 2016-2018, the incidence rate of salmonellosis in Bulgaria was close to that of the European Union (EU). It was 11,21 per 100 000 population in 2017 (14,6%ooo in the EU). The incidence rate of typhoid fever in Bulgaria was lower than that in the EU for the period 2016-2018 – 0.01-0.03 per 100 000 population. Bulgaria had the highest rate of shigellosis in the EU. For the period 2016-2018 it was between 3,33%ooo and 4,07 per 100 000. The incidence of Campylobacter infection in Bulgaria during the period 2016-2018 was between 2,72%ooo and 2,88%ooo and was lower than the EU average. Data on yersiniosis in Bulgaria is incomplete. For the period 2016-2018, 36 cases were reported. E. coli enteritis had a higher average annual notification rate in the 0 to 1 age group (142,65 cases per 100 000 population). The main means of controlling intestinal infection are sanitary measures that prevent the transmission of pathogenic microorganisms with food, water, insects, contaminated hands, etc.