bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of zirconium arsenate‐modified monolithic column for selective enrichment of phosphopeptides
Authors: Qin Zhang‐Na , Chen Xi , Yu Qiong‐Wei , Ding Jun , Feng Yu‐Qi 
Published: November 2020

AbstractProtein phosphorylation is a crucial posttranslational modification for the regulation of many different biological functions. Selective enrichment of phosphopeptides from the complex biological samples is an essential step for the mass spectrometry analysis of protein phosphorylation. In this study, an arsenate functionalized monolithic column was first prepared by a single‐step copolymerization of p‐methacryloylaminophenylarsonic acid and ethylene dimethacrylate. Then the metal ions Zr4+ were attached onto the prepared monolithic column via metal‐chelate complex formation by Zr4+ and arsenate groups. The obtained monolithic column was employed as a new sorbent for the phosphopeptide enrichment via immobilized metal affinity chromatography. Phosphopeptides analysis was realized by polymer monolith microextraction using this monolithic column coupled to both matrix‐assisted laser desorption/ionization mass spectrometry and liquid chromatography–electrospray ionization tandem mass spectrometry. The proposed method exhibited a high selectivity for phosphopeptide enrichment in complex matrices, and was applied to the analysis of phosphopeptides in human serum and tryptic digests of rat brain proteins. Four phosphopeptides could be selectively captured from human serum and 2608 endogenous phosphopeptides were identified from the tryptic digests of rat brain proteins, indicating a satisfactory performance of this method for the enrichment of phosphopeptides from complex biological samples.
Examining the impact of rangeland condition on water conservation by using an integrated modelling approach
Authors: Azimi Mojgansadat , Barzali Masoud , Abdolhosseini Mohammad , Lotfi Abdolrahim 
Published: November 2020

AbstractRangelands in the arid and semi‐arid regions of Iran are under pressure from frequent degradations and extreme climate conditions, which have affected water conservation and delivery of ecosystem services. The timely and efficient assessment of rangeland state/condition impact on water conservation is crucial in rangeland management. This work represents an integrated modelling approach by linking the Soil and Water Assessment Tool (SWAT) and the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) models. SWAT simulated hydrologic components, while InVEST provided a decision support system for water conservation. The coupled SWAT–InVEST model was used to analyze the impact of different rangeland conditions on water conservation in the Atrak River basin in Iran's arid and semi‐arid climatic zones. Increasing runoff is proportional to rangeland degradation. Our analyses show a severe degradation of rangelands in Iran. We found that the basin's average runoff varies between 2 and 294.8 m3 ha‐1 yr‐1. Based on our modelling results, about 50% of the basin's runoff came from poor rangelands, 22% from moderate rangelands, and 28% from good rangelands. Thus, a significant impact on water conservation could be achieved through rangeland management in this basin. The SWAT–InVEST integrated modelling approach developed here proved useful for better decision‐making under uncertainty.
Ursodeoxycholic Acid Decreases Incidence of Primary Biliary Cholangitis and Biliary Complications After Liver Transplantation: A Meta‐Analysis
Authors: Pedersen Mark R. , Greenan Garrett , Arora Sumant , Murali Arvind R. , Mayo Marlyn J. 
Published: November 2020

After liver transplantation (LT), the role of ursodeoxycholic acid (UDCA) is not well characterized. We examine the effect of UDCA after LT in the prophylaxis of biliary complications (BCs) in all‐comers for LT and the prevention of recurrent primary biliary cholangitis (rPBC) in patients transplanted for PBC. Two authors searched PubMed/MEDLINE and Embase from January 1990 through December 2018 to identify all studies that evaluate the effectiveness of UDCA prophylaxis after LT for BCs in all LT recipients and rPBC after LT in patients transplanted for PBC. Odds ratios (ORs) were calculated for endpoints of the BC study. Pooled recurrence rates were calculated for rPBC. The study was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta‐Analysis guidelines. A total of 15 studies were included, comprising 530 patients in the analysis for BCs and 1727 patients in the analysis for rPBC. UDCA was associated with decreased odds of BCs (OR, 0.70; 95% confidence interval [CI], 0.52‐0.93; P = 0.01) and biliary stones and sludge (OR, 0.49; 95% CI, 0.24‐0.77; P = 0.004). Prophylactic use of UDCA did not affect the odds of biliary stricture. For patients transplanted for PBC, the rate of rPBC was lower with the prophylactic use of UDCA (IR 16.7%; 95% CI, 0.114%‐22.0%; I2 = 36.1%) compared with not using prophylactic UDCA (IR 23.1%; 95% CI, 16.9%‐29.3%; I2 = 86.7%). UDCA after LT reduces the odds of BC and bile stones and sludge in all‐comer LT recipients and reduces or delays the incidence of rPBC in patients transplanted for PBC. UDCA use after LT could be considered in all LT recipients to reduce the odds of BC and may be particularly beneficial for patients transplanted for PBC by reducing the incidence of rPBC.
Electrospinning of Poly(1,4‐Cyclohexanedimethylene Acetylene Dicarboxylate): Study on the Morphology, Wettability, Thermal and Biodegradation Behaviors
Authors: Daglar Ozgun , Altinkok Cagatay , Acik Gokhan , Durmaz Hakan 
Published: November 2020

AbstractThis study is conducted to evaluate the biodegradation and thermal features of poly(1,4‐cyclohexanedimethylene acetylene dicarboxylate) (PCA) based films and fibers. The PCA is characterized by Fourier transform infrared (FT‐IR) and proton nuclear magnetic resonance (1H‐NMR) spectroscopies and gel permeation chromatography (GPC). The beadless fibers of PCA are achieved by electrospinning from its solution under ambient conditions for the first time. The effects of applied voltage and tip‐to‐collector distance (TCD) on the various properties such as morphology, wettability, thermal, and biodegradability behaviors of fibers are investigated by comparing the non‐electrospun PCA. Morphologies and average frequency distributions of the electrospun samples are elucidated by scanning electron microscopy (SEM). Wettability properties of the studied samples are determined by water contact angle (WCA) measurements, whereas thermo‐stabilities and glass transition temperatures (Tg) are established by thermogravimetric and differential scanning calorimetry analyses (TGA and DSC), respectively. Biodegradation studies indicate that 28% of electrospun PCA achieved at 8 mL h−1 flow rate, 20 cm TCD and 25 kV applied voltage can be enzymatically degraded within 15 days. It is thus estimated that PCA with good electrospun and biodegradation abilities will favorable candidates for bio‐polyester applications.
The interplay between emitter conformality and field‐effect passivation in pyramid structured silicon solar devices
Authors: Razzaq Arsalan , Depauw Valérie , John Joachim , Gordon Ivan , Szlufcik Jozef , Abdulraheem Yaser , Poortmans Jef 
Published: November 2020

AbstractLight management in crystalline silicon solar cells has conventionally been achieved by random micropyramid texturing but other non‐conventional surface texturing methods, such as diffraction gratings, have also attracted attention with the objective of attaining near‐ideal light trapping. Unlike previous investigations on the subject in which the focus was predominantly to minimize optical losses, we report on surface passivation difference between the micron and nanoscale pyramid textures. From simulations, we find that the conformality of thermally diffused emitters is impacted by downsizing the pyramid texture to the light wavelength scale, which, in turn, affects the field‐effect passivation of the resulting homojunction. The investigation reveals that, for a conformal junction, the field‐effect passivation is diminished due to the formation of weak electrical field zones beneath the pyramid vertices, which is usually the case when homojunction emitters are formed by thermal diffusion on micropyramid textured surfaces. In contrast, thermal diffusion in nanoscale pyramid textured surfaces typically leads to non‐conformal dopant profiles, resulting in flatter junctions and yielding stronger field passivation effect by preventing the formation of these weak electrical field zones. Experimentally, enhanced field‐effect passivation is indirectly observed in terms of improvement in the effective minority‐carrier lifetimes when substituting the standard micropyramid texturing by nanoscale pyramid gratings. At the device level, we demonstrate that the enhancement in the field‐effect passivation increases the open‐circuit voltage with respect to the micropyramid texture under the conditions of comparable chemical passivation and surface‐area increase.
Brigatinib Dose Rationale in Anaplastic Lymphoma Kinase–Positive Non‐Small Cell Lung Cancer: Exposure–Response Analyses of Pivotal ALTA Study
Authors: Gupta Neeraj , Wang Xiaohui , Offman Elliot , Rich Benjamin , Kerstein David , Hanley Michael , Diderichsen Paul M. , Zhang Pingkuan , Venkatakrishnan Karthik 
Published: November 2020

Brigatinib is a kinase inhibitor indicated for patients with advanced anaplastic lymphoma kinase–positive non‐small cell lung cancer who progressed on or are intolerant to crizotinib. Approval was based on results from a randomized, dose‐ranging phase II study (ALK in Lung Cancer Trial of AP26113 (ALTA)). Despite an apparent dose–response relationship for efficacy in ALTA, an exposure–response relationship was not discernable using static models driven by time‐averaged exposure. However, exposure–response modeling using daily time‐varying area under the concentration curve as the predictor in time‐to‐event models predicted that increasing the dose of brigatinib (range, 30 mg once daily (q.d.) to 240 mg q.d.) would result in clinically meaningful improvements in progression‐free survival (PFS), intracranial PFS, and overall survival. Grade ≥ 2 rash and amylase elevation were predicted to significantly increase with brigatinib exposure. These results provided support for a favorable benefit‐risk profile with the approved dosing regimen (180 mg q.d. with 7‐day lead‐in at 90 mg) versus 90 mg q.d.
Event‐triggered control of input‐affine nonlinear interconnected systems using multiplayer game
Authors: Narayanan Vignesh , Modares Hamidreza , Jagannathan Sarangapani 
Published: November 2020

AbstractIn this article, we present a decentralized control scheme for regulating input‐affine nonlinear interconnected systems. In particular, we propose a codesign strategy to synthesize a control policy and an event‐triggering threshold at each subsystem of an interconnected system to simultaneously optimize the subsystem performance and reduce the computational burden on the controllers by enforcing aperiodic dynamic feedback. To this end, we formulate a differential game at every subsystem to design a decentralized control scheme in which we treat the control policy as the minimizing player and model the effect of interconnection inputs and the error introduced due to aperiodic feedback as a team of adversarial players. We then employ the solution to the proposed game for designing both the control policy and the event‐triggering threshold at each subsystem. With the proposed approach, we also derive the conditions that guarantee the input‐to‐state stability of the overall system by leveraging the well‐known small‐gain theorem. Moreover, we show that these conditions, expressed in terms of the attenuation constants and penalty matrices introduced in the formulated game, are obtained as linear inequalities even when the dynamics of the subsystems are nonlinear. Finally, we illustrate the applicability of the proposed scheme to regulate interconnected systems using numerical examples.
Unemployment Benefits: Discursive Convergence, Distant Realities
Authors: Martín-Artiles Antonio , Fortunato Vincenzo , Chávez-Molina Eduardo 
Published: November 2020

AbstractUnemployment protection systems have certain characteristics in common in Argentina, Uruguay, Spain and Italy: they are compulsory and contributory-proportional, although in Uruguay, it also has a capitalisation supplement. Despite the similarities, they work differently because the context of informal employment chiefly, and unemployment, low salaries and precariousness differ greatly. Consequently, the unemployment protection coverage rate varies. Theories of the Active Welfare State, the Investor State and the reforms of unemployment protection systems have led to a certain modernising language being adopted in these countries: activation, employability, conditionality, lifelong learning, flexibility, which are, among others, words shared with Europe.However, the meanings of these words differ according to the institutional context of each country. In Latin America the welfare state is low institutionalised even almost non-existent, while in Europe it is a diverse institution. Despite this, the four countries share an upward trend in benefit policies, in accordance with the increase in poverty risk.
Developing a Digital Entrepreneurial Mindset for Data-Driven, Cloud-Enabled, and Platform-Centric Business Activities: Practical Implications and the Impact on Society
Authors: Soltanifar Mariusz , Smailhodžić Edin 
Published: November 2020

AbstractThe term ‘digital’ concerns not only technology but also people. This chapter emphasises the necessity of adopting a digital entrepreneurial mindset when operating in a digitised world. The chapter proposes a definition of a digital entrepreneurial mindset that is rooted in cognitive psychology, organisation theory and entrepreneurship literature. We also focus on the five trends that are shaping the digital future: mobile computing, cloud computing, social media, the Internet of Things and Big Data. The chapter discusses the challenges and opportunities that pervasive digitalisation offers for designing new digital business models and changing interactions with customers. Discussing the success stories of Domino’s Tesco and Tate Art Galleries helps to examine data-driven, cloud-enabled, platform-centric business activities, for which developing a digital entrepreneurial mindset is the first step towards success in the digital age. Collectively, the aforementioned cases suggest that businesses that rely on a digital entrepreneurial mindset enjoy better financial performance. Both managers and employees in these companies have shown the inclination and ability to discover, evaluate and exploit opportunities emerging from digital technologies. This chapter also provides a practical guide for entrepreneurs on the steps they can take to encourage a digital entrepreneurial mindset throughout their entire organisations. Finally, we elaborate on the practical implications of adopting a digital entrepreneurial mindset and its impact on society.
Gestaltungsorientiert forschen lernen mit design thinking – Erläutert am Beispiel des Umgangs mit dem Lernfeldparadoxon der wirtschaftsberuflichen Bildung
Authors: Hantke Harald 
Published: November 2020

Zusammenfassung(Zukünftige) Lehrerinnen und Lehrer der wirtschaftsberuflichen Bildung sind mit dem so zu bezeichnenden Lernfeldparadoxon konfrontiert. So setzt sich der Lernfeldansatz als Curriculum der beruflichen Bildung aus folgenden zwei Perspektiven zusammen, die sich zu widersprechen scheinen: Dem im Lernfeld-Konzept formulierten (Bildungs-)Anspruch an eine nachhaltigkeitsorientierte wirtschaftsberufliche Bildung und dem in den Lernfeld-Vorgaben formulierten (Qualifikations-)Anspruch an eine wirtschaftsberufliche Bildung, die sich an betrieblichen Situationen orientiert. Der Lernfeld-Ansatz stellt (zukünftige) Lehrerinnen und Lehrer somit vor die Herausforderung, sowohl der Perspektive des Lernfeld-Konzepts als auch der Perspektive der Lernfeld-Vorgaben nachzukommen. Mit dieser Herausforderung setzen sich zukünftige Lehrkräfte in ihrem Bachelorstudium „Wirtschaftspädagogik“ an der Leuphana Universität Lüneburg in einem gestaltungsorientierten Lern-Forschungs-Prozess auseinander. In diesem Beitrag werden konzeptionell-theoretische Einblicke in diesen Prozess gegeben, indem design thinking als gestaltungsorientierter Lern-Forschungs-Prozess rekonzeptionalisiert und am Beispiel eines Seminarkonzepts konkretisiert wird.
Interdisziplinäre Problemlösung konkret (IPK): Eine Methode für die sozioökonomische Hochschulbildung
Authors: Mayer Julia K. , Schröder Lisa-Marie 
Published: November 2020

ZusammenfassungDie Bürgerinnen und Bürger werden gegenwärtig mit zahlreichen gesellschaftspolitischen Problemstellungen konfrontiert, die mit einer rein ökonomischen, politischen oder soziologischen Sichtweise nicht zufriedenstellend zu betrachten sind. Der Beitrag stellt auf Basis dessen die Notwendigkeit eines neuen methodischen Settings dar, einer neuen Arbeitsweise, die diese Anforderungen adressiert. Diese Methode, die wir ‚Interdisziplinäre Problemlösung konkret (IPK)‘ nennen, beabsichtigt, Hürden bezüglich der Auseinandersetzung mit sozioökonomischen Themen abzubauen, indem ein inhaltlich wie methodisch ansprechendes, aktivierendes als auch motivierendes Lehr-Lernformat dargeboten wird, das Interdisziplinarität als essenzielles Wissenschaftsprinzip begreift. Ferner soll es Lehrenden wie Lernenden erleichtert werden, die Methode in der Berufspraxis – beispielsweise als angehende Lehrkräfte – einzusetzen, da IPK auf zahlreiche Themen, Fragestellungen wie auch Adressatengruppen angewandt werden kann.
Das Leipziger Erwägungsseminar. Ein didaktisch reflektierender Erfahrungsbericht
Authors: Boerger Lara 
Published: November 2020

ZusammenfassungVon 2006 bis 2019 wurde an der Universität Leipzig das sog. Erwägungsseminar angeboten. Das Konzept des Seminares fußt auf der Erwägungsdidaktik der „Forschungsgruppe Erwägungskultur Paderborn“ und wurde Ende der 1980er Jahre entwickelt. Die Grundidee umreißt einen spezifischen erwägungsorientierten Umgang mit Alternativen. Demnach soll das Wissen von Expertinnen und Experten nicht als gesetzt, gesichert, und unumstößlich gelten. Vielmehr geht es darum, Theorien zu hinterfragen, zu vergleichen und einen integrierten und bewahrenden Umgang mit unterschiedlichen Erklärungsansätzen zu praktizieren. Die zentralen Forderungen des Netzwerk Plurale Ökonomik – Selbstkritik, Reflexion und Offenheit in der VWL zu fördern – werden aufgegriffen und stellen meines Erachtens das vorrangige Ziel der Lehrveranstaltung dar.
Plurale Einführung in die VWL? Zu den Gestaltungsmöglichkeiten pluraler Einführungsveranstaltungen
Authors: Thieme Sebastian 
Published: November 2020

ZusammenfassungMit dem Verweis auf einen umfangreichen Kanon wirtschaftswissenschaftlichen Wissens wird seitens etablierter Fachvertreterinnen und -vertreter der (Standard-)Ökonomik häufig argumentiert, dass dieser keinen Raum lasse, um Perspektiven der Pluralen Ökonomik in entsprechende Lehrveranstaltungen zu integrieren. Dagegen lässt sich anführen, dass z. B. Einführungslehrbücher der VWL mehrere 100 Seiten umfassen und der dort präsentierte Inhalt daher bereits aus praktischen Gründen für die Lehre reduziert werden muss. Vor diesem Hintergrund und basierend auf Erfahrungen mit einer Einführungsveranstaltung in die VWL werden im vorliegenden Beitrag Gestaltungsmöglichkeiten diskutiert, die auch in bestehenden Curricula genutzt werden können, um den Lehrveranstaltungen zur Ökonomik eine kritische Perspektive im Sinne der Pluralen Ökonomik zu ermöglichen.
Plurale Lehre in den Wirtschaftswissenschaften an der Georg-August-Universität Göttingen
Authors: Berner Anne , Dorn Franziska , Ochsner Christian , Silbersdorff Alexander , Wolfinger Lukas 
Published: November 2020

ZusammenfassungIn diesem Beitrag zeigen wir auf, welche Entwicklungen in der wirtschaftswissenschaftlichen Lehre an der Universität Göttingen 2007 zur Gründung einer Hochschulgruppe führten und wie diese die Lehre an der Wirtschaftswissenschaftlichen Fakultät um eine pluralistische Perspektive ergänzt hat. Im Zuge dessen werden wesentliche Defizite der Lehrsituation aufgezeigt, das Kooperationsverhältnis mit der Fakultät erörtert und die gruppeninternen Prozesse, die der studentisch gestalteten Lehre zugrunde liegen, diskutiert. Wir legen am Beispiel von studentisch organisierten Seminaren und Ringvorlesungen dar, unter welchen Bedingungen pluralistische Lehre einen Beitrag leisten kann, die Mängel in der Lehre zu beseitigen und wie dies auf die Hochschulgruppe und die Fakultät zurückwirkt..
Low-Profit im Kontext der UN-Nachhaltigkeitsziele
Authors: Fahrbach Christian , Weiser Annika 
Published: November 2020

ZusammenfassungAn der Leuphana Universität Lüneburg findet jedes Jahr das Leuphana-Semester statt, das alle Studierende im ersten Semester durchlaufen, bevor sie im zweiten Semester ins Fachstudium starten. Die Studierenden sollen in Projektseminaren wissenschaftliche Methoden kennen lernen und einüben, an konkreten gesellschaftlichen Problemen erproben und interdisziplinäre Lösungswege aufzeigen. Im Wintersemester 2018/2019 wurde erstmals ein Projektseminar zum Thema Low-Profit angeboten. Dabei wurde die Lehrmethode Forschendes Lernen angewendet, bei der die Studierenden gefordert waren, das Thema Low-Profit mit den sustainable development goals (SDG) zu verbinden, dazu eine relevante Forschungsfrage zu formulieren und in Gruppenarbeit einen gemeinsamen Projektbericht zu erstellen.
Using Academic Travel to Teach Sustainable Economic Development
Authors: Dasgupta Poulomi 
Published: November 2020

AbstractSustainable Development has become dominant in policy debates in the last two decades. Standard models in neoclassical economics as taught in undergraduate classes fail to capture the complex relationships between the economy and the environment. This creates a major gap in students’ understanding of sustainable development. We make the case that innovative teaching technique will allow students to better grasp this complex relationship. We examine the integration of academic travel into the economics curriculum as a tool to expose students to important aspects of sustainable development and allow them to gain a more meaningful insight into the subject.
Addendum to: Light-cone distribution amplitudes of pseudoscalar mesons from lattice QCD
Authors:   on behalf of the RQCD collaboration, Bali Gunnar S. , Braun Vladimir M. , Bürger Simon , Göckeler Meinulf , Gruber Michael , Hutzler Fabian , Korcyl Piotr , Schäfer Andreas , Sternbeck André , Wein Philipp 
Published: November 2020

Abstract
We update our lattice determination of the two lowest Gegenbauer moments of the leading-twist pion and kaon light-cone distribution amplitudes [1]
SARS-CoV-2: Remarks on the COVID-19 Pandemic
Authors: Piasecki Egbert 
Published: November 2020

AbstractThe COVID-19 pandemic developing rapidly in 2020 is triggered by the emergence of a new human virus—SARS-CoV-2. The emergence of a new virus is not an unexpected phenomenon and has been predicted for many years. Since the virus has spread all over the world, it will be very difficult or even impossible to eradicate it. A necessary condition for complete or partial elimination of the virus is to have an effective vaccine. It is possible that SARS-CoV-2 will become milder in the next few years and COVID-19 will then only threaten individuals from risk groups.