bluuebunny/crossref_metadata_2025_split huggingface dataset:
P93 Relationship Between Central Pressure and Urinary Sodium Excretion in a Population-based Study in Salvador, Brazil, Preliminary Results
Authors: de Castro Roberta , Magalhães Lucélia , Brustolim Danielle , Silva Diorlene da , Filho Antonio , Bessa Larissa , Vascor Grupo 
Published: March 2020

Abstract
Introduction
Central pressure (CP) has shown to be more reliable than cardiovascular mortality; salt intake in the diet is directly related to the increase in CP.

Methods
A population-based cross-sectional study representative of a neighborhood of Salvador-BA, Brazil, distributed in 12 census tracts according to the Brazilian Institute of Geography and Statistics. The overall sample is randomized in adults from the assigned area, from December 2016 to May 2019 comprise 145 people. The central pressure, measured in the radial artery, obtained through aplanation tonometry, using the SphygmoCor® apparatus (XCEL, AtCor Medical, Sydney, Australia, [2] with confidence ≥85%). PC is evaluated directly by the central systolic pressure and diastolic pressure. Collected blood and urine sodium 24 hours were quantified by the ADVIA 1800® selective ion electrode (SiemensHealthcare Japan/Canada), and all participants signed a Free and Informed Consent Form. Mean, standard deviation, Spearman’s linear correlation coefficient between CP and Na+, stratified by age and sex, using STATA v.12 software for treatment and generation of results, and the level of significance statistic of 5%.

Results
For both sexes, were inversely proportional, although not significant.

Conclusion
The results obtained aren’t adequate as evidence in the literature. A larger sample is needed for accuracy in this group.
P98 Impaired Pulmonary Function is Associated with Increased Cardio-ankle Vascular Index in HIV Patients in Ghana
Authors: Yeboah Kwame , Musah Latif , Essel Samuel , Dzudzor Bartholomew , Cruickshank J Kennedy 
Published: March 2020

Abstract
Aim
Patients with HIV have increased cardiovascular risk and pulmonary defects. We investigated the association between impaired pulmonary function (IPF) and arterial stiffening measured by the cardio-ankle vascular index (CAVI) in Ghanaian HIV patients.

Method
Spirometry was used to measure pulmonary indices; forced expiratory volume in 1s (FEV1) and forced vital capacity (FVC) in 79 HIV patients on treatment, 75 HIV treatment naïve patients and 78 non-HIV controls. We also used FEV1/FVC < lower limit of normal as a further index. Arterial stiffness was measured as CAVI using the Vasera device.

Results
Compared to non-HIV controls, CAVI was higher in treatment naïve (6.9 ± 1.4 vs 6.3 ± 1.1 units, p < 0.01) and HIV patients on treatment (8.1 ± 1.4, vs 6.3 ± 1.1, p < 0.01). IPF was detected in 12 (15.2%) HIV patients on treatment, 8 (10.7%) treatment naïve HIV patients and 5 (6.4%) non-HIV controls. Compared to those without IPF, IPF patients had higher CAVI in non-HIV controls (6.5 ± 1.1 vs 5.7 ± 0.8, p < 0.01), treatment naïve HIV patients (7.1 ± 1.8 vs 6.6 ± 1.4, p = 0.023) and HIV patients on treatment (7.8 ± 1.4 vs 8.7 ± 1.2, p < 0.01). In multivariable logistic regression analysis, IPF was independently associated with CAVI [adjusted OR = 1.33 (1.15 — 1.89), p = 0.037] after adjustment for age [1.21 (0.98 — 2.14), p = 0.11], male sex [0.42 (0.32 — 0.91), p = 0.035], current/former smoking status [1.43 (0.47 — 4.01), p = 0.75] and history of tuberculosis infection [1.96 (1.08 — 3.12), p < 0.01].

Conclusion
Ghanaian HIV patients have a high prevalence of impaired respiratory function and arterial stiffening, and these indices are associated with each other.
P101 Arterial Stiffness vs Sarcopenia in Portuguese Elderly Population
Authors: Vassilenko Valentina , Serrano Andreia , Ramalho Beatriz , Bonifácio Paulo , Coelho Ana C. , Pimentel-Santos Fernando 
Published: March 2020

AbstractAging often results in the appearance of sarcopenia, which is characterized by loss of muscle mass and strength. The incidence of sarcopenia in the elderly is a quite common and leads to weakness and disability, as well as a lower quality of life, also assuming a high social and economic impact. One previous study has shown an independent negative association between arterial stiffness and skeletal muscle mass decline [1], which suggest its relationship with sarcopenia. This work aims to evaluate the relation between sarcopenia and the arterial stiffness, in Portuguese elderly population A cohort of 38 elderly volunteers between 67 and 95 years, with and without Sarcopenia, were selected from nursing homes and day centers of Portuguese charity institution -Santa Casa da Misericórdia de Almada. All volunteers have the same living condition, meals and lifestyle routine, excepting the medications. The diagnosis and degree (severe or moderate) of sarcopenia were performed according to the European consensus on definition and diagnosis of sarcopenia [2] at the same day with arterial stiffnesses measurements assessed by carotid-femoral Pulse Wave Velocity (cfPWV). Our data show a positive correlation for cfPWV with the sarcopenia severity degree, which represents an increasing in arterial stiffness and might be explained by the fact that the loss of muscle mass is often associated with chronic inflammation [3]. Despite of the small cohort size, the male gender held a bigger mean value of cfPWV, with significant p-value (0.014), in comparison to the female gender, which estimates a higher CV risk for the male elders of the region of Almada and Greater Lisbon compared to the female gender. Further investigations would be desirable in order to obtain larger samples and ascertain the estimates for the respective groups.
P105 Photoplethysmographic Signals Analysis Before, During, and After the Finnish Sauna Exposures
Authors: Huotari Matti 
Published: March 2020

AbstractWellness and healthiness depend on physiology if no illness exists in the body. As a treatment either in healthy or sick state, we suggest that sauna exposure could be good for cardiovascular disease (CVD) prevention, especially heart and brains arteries. We measured by our photoplethysmographic (PPG) device the responses caused by sauna exposure on the healthy males and females (10 + 7). As a working hypothesis, the sauna exposure could lower blood pressure and refresh the arterial wall facilitating the blood flow. The mechanisms as a whole have not been enough accurately documented. We recorded for 30 min in the 80°C dry sauna conditions the PPG signals for calculation of arterial elasticity (AE), and heart rate (HR) based on inter beat interval (IBI, the first-order difference), inter beat interval variability (IBIV, the second order difference), and heart rate variability (HRV). IBI and IBIV signals were determined on the second order derivatives of photoplethysmographic (SDPPG) waveforms. For the both IBI and IBIV signals, we plotted them as Poincare plots (Figure 1) by OriginPro2019b (OriginLab). Based on the SDPPG signals from the finger and toe maxima A and B (the first maximum and minimum) we calculated both the EA for finger and toe arteries. The PPG waveforms were noiseless because the subjects were at rest and no extra morphologies exists in PPGs during the sauna exposures, like before and after sauna. In our knowledge, this is the first PPGs measured during the actual sauna exposures.
P106 Effect of Açaí-Juçara on Central Pressure in Individuals with Overweight or Obesity
Authors: Ortiz Tainah , Gorski Fernanda , Lehnen Tatiana , Boll Liliana , Eibel Bruna , Lehnen Alexandre , Barbosa Eduardo 
Published: March 2020

Abstract
Introduction
Açaí-juçara is a fruit with a antioxidant content that can modify the vascular environment and attenuate the effects of obesity.

Objective
To evaluate the effect of açaí-juçara on pulse pressure parameters in overweight or obese individuals.

Methods
Randomized clinical trial with 23 individuals of both sexes, 37.7 ± 1.5 y, body weight 85.0 ± 4.8 kg, BMI 32.4 kg/m2. The volunteers were randomly assigned to: control group (C, n = 10) and açaí-juçara group (AJ, n = 13). Both received hypocaloric diets, representing 20% below the total energy value. AJ received, in the composition of the diet, 200 g of açaí-juçara for daily consumption. The intervention was 12 weeks and the follow-up was performed with weekly meetings. We analyzed parameters of peripheral blood pressure: systolic blood pressure (SBP) and diastolic blood pressure (DBP); parameters of central blood pressure: central pulse pressure (PPc), central systolic blood pressure (SBPc) and pulse wave velocity (PWV) with the oscillometric method (Mobil-O-Graph). Descriptive statistics (mean ± standard deviation) were performed and normality of the data was tested by Shapiro-Wilk. Possible differences were tested by ANOVA of repeated measures (Bonferroni post-hoc) with significance level of 5%. Results: After 12 weeks of intervention, body weight decreased in both groups (C: Δ3.2 kg; p = 0.050; AJ: Δ5.2 kg; p = 0.001). The peripheral SBP, PPc and PWV was lower in both groups (C: Δ3.8 mmHg, p = 0.040, AJ:Δ7.1mmHg, p = 0.031); (C: Δ5.5 unit, p = 0.044; AJ:Δ7.8 unit, p < 0.001); (p = 0.047) with greater effect in the AJ group (Δ0.4 unit; p = 0.006). Both groups reduced SBPc with more effect in the AJ group (Δ6.3 mmHg, p = 0.034).

Conclusion
AJ showed benefits on peripheral SBP, PPc, PWV and SBPc when compared to the control group.
P107 Endothelial Dysfunction Associated with Arterial Stiffness in Postmenopausal Women with Obesity
Authors: Lizette Ramírez Soltero Patricia , Benavides Leonel García , Pantoja Marycruz Barocio , Illescas Vidrio Brandon Giovanni , Müller David Cardona , Cardona Muñoz Ernesto Germán , Totsuka Sutto Sylvia Elena 
Published: March 2020

Abstract
Background
Endothelial dysfunction (ED) represents an initial step of “vascular failure” [1]; several factors affect the functionality of the endothelium. Obesity [2] and estrogen deficiency [3] are independently associated with this. The early detection of ED is essential to intervene and prevent its progression. One of the most promising methods to assess vascular endothelial function is the measurement of endothelium- dependent flow-mediated vasodilation (FMD) [1]. Similarly, pulse wave velocity (PWV) is considered as a predictive value for the stratification of vascular risk [4], however, progression between endothelial events and arterial stiffness continues to be examined.

Objective
To evaluate the association between endothelial dysfunction and arterial stiffness in postmenopausal women with obesity.

Methods
Descriptive study of 19 postmenopausal women with grade I and II obesity, without associated comorbidities. Participants were classified into one of two groups: with ED (FMD < 6%) or non-ED (FMD > 6%). The hemodynamic metabolic, hormonal and arterial stiffness parameters were evaluated.

Results
The group with ED (n = 10) compared to the non-ED group (n = 9) presented age 57.30 ± 4.80 vs 52.40 ± 5.70 years (p = NS); BMI 34.75 ± 2.06 vs 33.06 ± 2.51 kg/m2 (p = NS). Statically significant findings include: FSH 35.43 ± 11.04 vs 55.19 ± 19.27 mUI/ml (p = 0.018); PWV 9.18 ± 1.84 vs 7.52 ± 1.26 m/s (p = 0.041); central SBP 135 ± 15.90 vs 120 ± 18.2 mmHg (p = 0.041). We also measure estradiol, QIMT, SBP, DBP, PP, AIx, LDL-C, HDL-C and triglycerides, no significant differences were observed.

Conclusion
We can conclude that in the group with endothelial dysfunction the PWV and the cSBP are higher with a significant difference.
P108 Relation Between Abdominal Aorta and Carotid Artery Responses to Sympathetic Stimulation using Duplex Ultrasound
Authors: Jansen Anne-Jet , Vermeulen Jenske , Holewijn Suzanne , Thijssen Dick , Reijnen Michel 
Published: March 2020

Abstract
Background
Sympathetic stimulation in central arteries, such as the carotid artery, lead to vasodilation in healthy subjects and vasoconstriction in those with cardiovascular disease. Moreover, this response has independent prognostic value for future events. Whether the aorta demonstrates similar responsiveness is unknown. This is relevant, since this may help to better predict outcomes and progression in abdominal aortic aneurysm (AAA).

Objective
The aim of this explorative study is to investigate the correlation between the magnitude of the abdominal aorta and the carotid artery diameter and blood flow responses during the sympathetic stimulation (using the Cold Pressor Test (CPT)) between healthy young, healthy older and individuals with AAA.

Method
In this explorative study 60 subjects will be included divided into a healthy young group, healthy older group and an AAA group. All subjects will undergo the CPT, while using duplex ultrasound to simultaneously examine the diameter and blood velocity of the abdominal aorta and carotid artery.

Results
We aim to present our first results of the correlation between the abdominal aorta and carotid artery parameters at the conference.

Conclusion
When confirming a correlation between the magnitude of the abdominal aorta and the carotid artery diameter during the CPT, assessment of carotid artery reactivity to CPT may represent a simple, surrogate measure of central (i.e. aorta) endothelial function. This may help in predicting AAA progression and improve decision-making for treatment.
P112 Influence of Cuff Blood Pressure Accuracy on Identification of Isolated Systolic Hypertension
Authors: Picone Dean , Schultz Martin , Armstrong Matthew , Bos Willem , Dwyer Nathan , Lacy Peter , Laugesen Esben , Omboni Stefano , Pucci Giacomo , Roberts-Thomson Philip , Stouffer George , Takazawa Kenji , Weber Thomas , Westerhof Berend , Sharman James 
Published: March 2020

Abstract
Introduction
Isolated systolic hypertension (ISH) is the most common form of hypertension in older people. However, accurate identification of ISH may be hindered because cuff blood pressure (BP) underestimates systolic BP (SBP) and overestimates diastolic BP (DBP). This study aimed to determine the influence of cuff BP accuracy on the identification of ISH.

Methods
Cuff BP and invasive aortic BP were measured simultaneous (or near-simultaneously) in 1737 subjects (63 ± 12 years, 68% male) during coronary angiography. Data was derived from 32 studies, using 20 different cuff BP devices, from the Invasive Blood Pressure Consortium (INSPECT). ISH was defined as ≥140/<90 mmHg according to cuff BP and invasive aortic BP.

Results
According to cuff BP, 25% of subjects (n = 430) had ISH, however, 37% (n = 648) were identified with ISH from invasive aortic BP. There was 77% concordance between cuff and invasive BP for identifying ISH. Among the 23% (n = 408) of subjects misclassified by cuff BP, 38% (n = 155) of misclassification was from SBP underestimation (mean: −16.6, 95% CI: −18.9 to −13.9 mmHg), whereas 35% (n = 143) was from DBP overestimation (15.6, 11.9 to 19.0 mmHg) and 20% (n = 83) from SBP overestimation (17.6, 14.4 to 20.5 mmHg). Subjects misclassified were on average 2.7 years older and had greater body mass index (0.8 kg/m2) than those correctly classified.

Conclusion
Approximately one quarter of older subjects have ISH misclassified, mostly because of underestimation of cuff SBP and overestimation of cuff DBP. This demonstrates a need to improve the accuracy of cuff BP methods for greater precision in identifying ISH.
P116 Post-stroke White Coat Hypertension/Effect is Associated with Greater Arterial Stiffness
Authors: Kirkham Fran , Saunders A , Nuredini GN , Drazich E , Rankin Philip , Bunting E , Ali K , Okorie M , Rajkumar C 
Published: March 2020

Abstract
Objective
White coat hypertension/effect (WCH/E) describes an elevated clinic blood pressure (BP) with normal daytime ambulatory BP (ABPM) values. It is not clear whether WCH/E is associated with adverse vascular risk. This study aimed to determine the relationship between WCH/E and arterial stiffness in a cohort of patients who had a transient ischaemic attack (TIA) or lacunar stroke (LS).

Design and Method
The Arterial Stiffness In Lacunar Stroke and TIA (ASIST) study recruited 96 patients, aged over 40 years old, with a confirmed diagnosis of TIA or LS in the preceding 14 days. Patients were grouped by BP. Thirty-four patients were excluded (n = 6 declined ABPM, n = 3 masked hypertension and n = 25 sustained hypertension). Thirty-two patients with normal BP (clinic BP < 140/90 mmHg and day-time ABPM < 135/85 mmHg), and 30 patients with WCH/E (clinic BP > 140/90 mmHg and day-time ABPM < 135/85 mmHg) were recruited. Arterial stiffness was measured using carotid-femoral pulse wave velocity (PWV), (Complior®, ALAM Medical) and carotid-ankle vascular index (CAVI), (VaSera VS-1500 N®, Fukuda Denshi).

Results
Compared to patients with normal BP, patients with WCH/E were older, had a higher body mass index (BMI) and higher arterial stiffness measured by CAVI (10.3 ± 1.3 vs 9.4 ± 1.7, p = 0.027), and PWV (11.9 ± 3.0 vs 9.6 ± 2.3 ms−1, p = 0.002). The WCH/E cohort had more lacunar strokes (p = 0.039).

Conclusion
In this population of post-stroke patients, those with WCH/E had greater arterial stiffness and a higher prevalence of lacunar stroke. These results suggest that WCH/E is associated with adverse cardiovascular risk.

Normotension (N = 32)
WCH/E (N = 30)
Statistical significance

Male, n (%)
21(66)
22(73)
0.511

Age (years)
69.9 ± 11.5
75.7 ± 9.3
0.033

BMI (kg/m2)
25 ± 4
28 ± 4
0.014

Anti-hypertensive use, n (%)
19(59)
23(77)
0.146

Clinic systolic BP (mmHg)
125 ± 9
155 ± 13
<0.001

Clinic diastolic BP (mmHg)
75 ± 7
81 ± 8
0.003

Daytime systolic ABPM (mmHg)
114 ± 10
121 ± 10
0.007

Daytime diastolic ABPM (mmHg)
73 ± 7
72 ± 7
0.586

CAVI
9.4 ± 1.7
10.3 ± 1.3
0.027

PWV (ms−1)
9.6 ± 2.3
11.9 ± 3.0
0.002

Stroke type

TIA, n (%)
25(78)
16(53)
0.039

Lacunar, n (%)
7(22)
14(47)

Data expressed as mean ± standard deviation or number (percentage). Significance determined by t-test. Chi-squared used for anti-hypertensive use, gender and stroke type.
P118 Arterial Stiffness in Patients with Arterial Hypertension on Short Term Dual Treatment with Fimasartan/Amlodipine
Authors: Vidrio Brandon Giovany Illescas , Müller David Cardona , Muñoz Ernesto Germán Cardona , Ruiz Claudia Yanette Gálan , Becerra Carlos Gerardo Ramos , Páez Fernando Grover 
Published: March 2020

Abstract
Background
Pulse wave velocity (PWV) reflects arterial stiffness and is an independent predictor of cardiovascular mortality and morbidity. It is important to determine the effect dual therapy has on both BP and PWV.

Methods
A quasi-experimental study was performed in patients with grade 1 and 2 primary hypertension (HTN). Patients received the combination amlodipine/fimasartan (5 mg/60 mg/day) for 8 weeks. Anthropometric and hemodynamic measurements were made after a 2-week washout period and at week 8 of treatment. The brachial-ankle pulse wave velocity (baPWV), SBP, DBP, Pulse pressure (PP), central systolic blood pressure (cSBP) and the augmentation index normalized to 75 bpm (pAIx75) were measured.

Results
We included 42 patients (14 women) aged 56 ± 16 years. We observed a decrease in baVOP, 17.99 ± 2.80 m/s vs 16.14 ± 2.36 m/s, (p < 0.001); SBP 160 ± 18 mmHg vs 138 ± 14 mmHg (p < 0.001); DBP 96 ± 14 mmHg vs 82 ± 10 mmHg, (p < 0.001); PP 63 ± 18 mmHg vs 56 ± 14 mmHg, (p < 0.001); AIx75 85 ± 9% vs 80 ± 10%, (p = 0.002); and cSBP 151 ± 18 mmHg vs 128 ± 15 mmHg (p < 0.001). Before the treatment 71% patients had arterial stiffness and after the treatment only 33% of the patients had it, the BP goal of <130/80 was achieved in only 16%.

Conclusion
The short term dual therapy with amlodipine/fimasartan significantly decreased baPWV, cSBP, PP, SBP, DBP and pAIx75. Only 16% of the patients achieved the BP goal with this treatment.
P139 Does Early Life Programming Influence Arterial Stiffness and Central Hemodynamics in Adulthood? Could Birth Cohort Effects be of Importance?
Authors: Nilsson Peter , Sperling Johannes 
Published: March 2020

Abstract
Objective
Our aim was to investigate possible associations between birth weight (BW) and adult carotid-femoral Pulse Wave Velocity (cfPWV) and augmentation pressure index (AIx).

Design
This study including 1598 participants, 340 elderly subjects and 1258 young-middle aged subjects from the Malmö Offspring Study with data on birth weight and gestational age (GA). Participants underwent cfPWV and AIx measurements with Sphygmocor® (AtCor, Australia). Analysis of data was performed with multiple linear regression models with adjustments for age, sex, GA, and risk factors. Furthermore, comparisons were made between participants born prematurely or at term, or born small-for-gestational-age (SGA) or appropriate-for-gestational-age (AGA).

Results
Birth weight was positively associated with cfPWV after full adjustment (b = 0.057; p < 0.001), Figure 1, a finding that remained significant in the younger age group 18–27 years (b = 0.138, p = 0.008). Furthermore, birth weight was inversely associated with AIx (b = −0.058, p = 0.001). Subjects born SGA had significantly higher AIx (p = 0.007) and MAP (p = 0.037) compared to AGA born. Preterm-born subjects showed significantly higher systolic blood pressure compared to term-born (p = 0.034). Also, BW was inversely associated with MAP (b = −0.058, p = 0.017) and SBP (b = −0.047, p = 0.031), respectively.

Conclusion
Our findings suggest that changes in total peripheral resistance, rather than decreased arterial stiffness, may explain the observed inverse association between birth weight and SBP. Furthermore, the association between birth weight and cfPWV, shown strongest in the youngest age group (birth cohort), could possibly be explained by increasing maternal overweight/obesity. This calls for screening of risk factors in subjects with adverse conditions at birth.
Validation of a Method to Estimate Stroke Volume from Brachial-cuff Derived Pressure Waveforms
Authors: Weber Thomas , Wassertheurer Siegfried , Middlemiss Jessica , McEniery Carmel Mary , Hametner Bernhard , Mayer Christopher Clemens , Binder Ronald Karl , Feistritzer Hans-Josef , Klug Gert , Metzler Bernhard 
Published: March 2020

Abstract
Background
Steady state hemodynamics [Stroke Volume - SV, cardiac output, peripheral resistance (Rp)] have attracted researchers in hypertension for decades. However, due to technical difficulties, they never entered clinical medicine.

Objective
To investigate the performance of a model-based algorithm, utilizing brachial pressure waveforms obtained with a cuff, to estimate stroke volume. The model combines a modified three-element like Windkessel system and transmission line theory.

Participants and Methods
In study 1, 97 patients with reperfused acute myocardial infarction and two healthy controls underwent cardiac magnetic resonance imaging (1.5 Tesla Magnetom, Siemens, Germany), and SV was measured with standard protocols from short axis cine images (11 slices). In study 2, 19 healthy individuals (12 females) had SVs measured with inert gas rebreathing at rest, and during light exercise (20 watts) on a bicycle ergometer. In both studies, model-based SV, estimated with a brachial cuff, was the comparator.

Results
In study 1, both SVs were moderately correlated (r = 0.54, p < 0.001). Using the method of Bland–Altman, mean difference between both methods was 8.7 ml (1.96 limits of agreement were 36.7 and –19.3 ml), with no systematic bias. In study 2, both SVs were moderately correlated at rest (r = 0.63, p = 0.004) and at light exercise (r = 0.70, p = 0.0057). Using the method of Bland-Altman, mean difference between both methods was 8.6 ml (1.96 limits of agreement were 39.2 and –22.0 ml) at rest, and 42.7 ml (1.96 limits of agreement were 95.4 and –10.1 ml) at light exercise.

Conclusion
Brachial oscillometry and mathematical modeling provide a reasonable estimate of SV under static conditions, which may be a useful addition to 24-h measurements of blood pressure and pulsatile hemodynamics.