bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dyadic Synchrony and Responsiveness in the First Year: Associations with Autism Risk
Authors: Kellerman Ashleigh M. , Schwichtenberg A. J. , Abu‐Zhaya Rana , Miller Meghan , Young Gregory S. , Ozonoff Sally 
Published: September 2020

In the first year of life, the ability to engage in sustained synchronous interactions develops as infants learn to match social partner behaviors and sequentially regulate their behaviors in response to others. Difficulties developing competence in these early social building blocks can impact later language skills, joint attention, and emotion regulation. For children at elevated risk for autism spectrum disorder (ASD), early dyadic synchrony and responsiveness difficulties may be indicative of emerging ASD and/or developmental concerns. As part of a prospective developmental monitoring study, infant siblings of children with ASD (high‐risk group n = 104) or typical development (low‐risk group n = 71), and their mothers completed a standardized play task when infants were 6, 9, and/or 12 months of age. These interactions were coded for the frequency and duration of infant and mother gaze, positive affect, and vocalizations, respectively. Using these codes, theory‐driven composites were created to index dyadic synchrony and infant/maternal responsiveness. Multilevel models revealed significant risk group differences in dyadic synchrony and infant responsiveness by 12 months of age. In addition, high‐risk infants with higher dyadic synchrony and infant responsiveness at 12 months received significantly higher receptive and expressive language scores at 36 months. The findings of the present study highlight that promoting dyadic synchrony and responsiveness may aid in advancing optimal development in children at elevated risk for autism.Lay SummaryIn families raising children with an autism spectrum disorder (ASD), younger siblings are at elevated risks for social communication difficulties. The present study explored whether social‐communication differences were evident during a parent–child play task at 6, 9, and 12 months of age. For infant siblings of children with ASD, social differences during play were observed by 12 months of age and may inform ongoing monitoring and intervention efforts.
Dynamic monitoring of the effects of adherence to medication on survival in heart failure patients: A joint modeling approach exploiting time‐varying covariates
Authors: Spreafico Marta , Ieva Francesca 
Published: September 2020

AbstractAdherence to medication is the process by which patients take their drugs as prescribed, and represents an issue in pharmacoepidemiological studies. Poor adherence is often associated with adverse health conditions and outcomes, especially in case of chronic diseases such as heart failure (HF). This turns out in an increased request for health care services, and in a greater burden for the health care system. In recent years, there has been a substantial growth in pharmacotherapy research, aimed at studying effects and consequences of proper/improper adherence to medication both for the increasing awareness of the problem and for the pervasiveness of poor adherence among patients. However, the way adherence is computed and accounted for into predictive models is far from being informative as it may be. In fact, it is usually analyzed as a fixed baseline covariate, without considering its time‐varying behavior. The purpose and novelty of this study is to define a new personalized monitoring tool exploiting time‐varying definition of adherence to medication, within a joint modeling approach. In doing so, we are able to capture and quantify the association between the longitudinal process of dynamic adherence to medication with the long‐term survival outcome. Another novelty of this approach consists of exploiting the potential of health care administrative databases in order to reconstruct the dynamics of drugs consumption through pharmaceutical administrative registries. In particular, we analyzed administrative data provided byRegione Lombardia ‐ Healthcare Divisionrelated to patients hospitalized for HF between 2000 and 2012.
Cinnamaldehyde supplementation prevents fasting‐induced hyperphagia, lipid accumulation, and inflammation in high‐fat diet‐fed mice
Authors: Khare Pragyanshu , Jagtap Sneha , Jain Yachna , Baboota Ritesh K. , Mangal Priyanka , Boparai Ravneet K. , Bhutani Kamlesh K. , Sharma Shyam S. , Premkumar Louis S. , Kondepudi Kanthi K. , Chopra Kanwaljit , Bishnoi Mahendra 
Published: September 2020

AbstractCinnamaldehyde, a bioactive component of cinnamon, is increasingly gaining interest for its preventive and therapeutic effects against metabolic complications like type‐2 diabetes. This study is an attempt to understand the effect of cinnamaldehyde in high‐fat diet (HFD)‐associated increase in fasting‐induced hyperphagia and related hormone levels, adipose tissue lipolysis and inflammation, and selected cecal microbial count in mice. Cinnamaldehyde, at 40 µm dose, prevented lipid accumulation and altered gene expression toward lipolytic phenotype in 3T3‐L1 preadipocyte cell lines. In vivo, cinnamaldehyde coadministration prevented HFD‐induced body weight gain, decreased fasting‐induced hyperphagia, as well as circulating leptin and leptin/ghrelin ratio. In addition to that, cinnamaldehyde altered serum biochemical parameters related to lipolysis, that is, glycerol and free fatty acid levels. At transcriptional level, cinnamaldehyde increased anorectic gene expression in hypothalamus and lipolytic gene expression in visceral white adipose tissue. Furthermore, cinnamaldehyde also decreased serum IL‐1β and inflammatory gene expression in visceral white adipose tissue. However, cinnamaldehyde did not modulate the population of selected gut microbial (Lactobacillus, Bifidibaceria, and Roseburia) count in cecal content. In conclusion, cinnamaldehyde increased adipose tissue lipolysis, decreased fasting‐induced hyperphagia, normalized circulating levels of leptin/ghrelin ratio, and reduced inflammation in HFD‐fed mice, which augurs well for its antiobesity role. © 2016 BioFactors, 42(2):201–211, 2016
Does network work? Women business‐owners' access to information regarding financial support from development programme in Bangladesh
Authors: Jaim Jasmine 
Published: September 2020

AbstractWhile networking is crucial for accessing information of women entrepreneurs, this issue has been overlooked in developing nations. Exploring women business‐owners' networks for gathering bank loans related information is particularly significant for those developing countries where the government has taken an initiative to financially support women for their empowerment. Based on the interviews of women business‐owners in Bangladesh, this study explores their access to information concerning the development programme in terms of special bank loans. This research yields valuable insights concerning the nature and dynamics of informal and formal networks of women in gathering bank loans related information. Thus, within the context of development programmes, this research substantially contributes to the understanding of women's networking in developing nations. It also provides valuable suggestions for policy practitioners to empower women through development programmes.
LncRNA PITPNA‐AS1 boosts the proliferation and migration of lung squamous cell carcinoma cells by recruiting TAF15 to stabilize HMGB3 mRNA
Authors: Ren Ping , Xing Lei , Hong Xiaodong , Chang Liang , Zhang Hong 
Published: September 2020

AbstractPlenty of reports have probed the involvement of abnormally expressed lncRNAs in multiple cancers, including lung squamous cell carcinoma (LUSC). Through online database GEPIA, lncRNA PITPNA antisense RNA 1 (PITPNA‐AS1) was highly expressed in LUSC samples, and these tendency was further affirmed in LUSC cells. The aim of current study was to investigate the related mechanism of PITPNA‐AS1 in LUSC. Functional experiments verified that depletion of PITPNA‐AS1 hampered the proliferative and migratory abilities, but accelerated apoptosis of LUSC cells. Additionally, we observed the increased expression of HMGB3 and its positive correlation with PITPNA‐AS1 in LUSC samples. Interestingly, PITPNA‐AS1 mainly located in the cytosol of LUSC cells, and also affected mRNA stability of HMGB3. Furthermore, the repressed mRNA stability of HMGB3 by PITPNA‐AS1 via TAF15 was exposed through mechanism experiments. The mediatory function of PITPNA‐AS1 on HMGB3 was validated via rescue assays. All in all, PITPNA‐AS1 promoted the proliferation and migration of LUSC cells via stabilizing HMGB3 by TAF15. In conclusion, our study displayed a novel mechanism underlying PITPNA‐AS1 in LUSC cells.
Folding patch correspondence for multiview stereo
Authors: Liao Jie , Fu Yanping , Yan Qingan , Xiao Chunxia 
Published: September 2020

AbstractIn this article, we propose the novel folding patch model which can replace the traditional patch model utilized in patch‐based multiview stereo (MVS) methods to significantly improve the reconstruction results. The patch model is applied as an approximation of the scene surface differential in the geometric estimation procedure. By minimizing the photometric discrepancy of the projection of the patch model on multiple source images, patch‐based MVS algorithms optimize the position and normal values for the 3D hypothesis of the target pixel. The optimization is based on the assumption that the patch model can fit the target scene surface perfectly. However, when it comes to complex scenes crowded with sharp edges, splintery surfaces, or round surfaces, the patch model is inherently not suitable since even from the microscopic perspective these surfaces are not entirely flat. We construct the folding patch model by folding the traditional patch model from the middle line. By adjusting the folding angle and direction, the folding patch model can fit complex surfaces more flexibly. We apply our folding patch model to the representative open‐source patch based multiview stereo (PMVS) and COLMAP, and validate the effectiveness on ETH3D benchmark and data sets captured in nature. The results demonstrate that utilizing the folding patch model can significantly improve the behavior of PMVS and COLMAP, especially on data sets mainly consist of complex surfaces from plants.
Comparing the clinical and prognostic impact of proximal versus nonproximal lesions in dominant right coronary artery ST‐elevation myocardial infarction
Authors: Femia Giuseppe , Faour Amir , Assad Joseph , Sharma Lokesh , Idris Hanan , Gibbs Oliver , Pender Patrick , Leung Dominic , Hopkins Andrew , Rajaratnam Rohan , P Juergens Craig , Mussap Christian , K French John , Lo Sidney 
Published: September 2020

AbstractObjectiveTo evaluate the prognostic significance of culprit lesion location in dominant right coronary artery (RCA) ST‐elevation myocardial infarction (STEMI).BackgroundIn RCA STEMI, proximal culprit lesions have been shown to have higher rates of acute complications such as bradycardia and cardiogenic shock (CS) but data on mortality is limited.MethodsWe retrospectively identified and analyzed data from consecutive patients with a dominant RCA STEMI who underwent either primary or rescue percutaneous coronary intervention (PCI) between January 2003 and December 2016. We compared the rates of sustained ventricular tachycardia (VT), CS, intra‐aortic balloon pump (IABP), temporary cardiac pacing (TCP) and death between culprit lesions located proximal and distal to the origin of the last right ventricular (RV) marginal artery >1 mm in diameter.ResultsThe 939 patients were included; 599 (63.7%) had a proximal lesion and 340 (36.3%) had a nonproximal lesion. The 801 (85.3%) underwent primary PCI and 138 (14.7%) underwent rescue PCI. There was no difference in first medical contact to balloon or fibrinolysis times between the groups; p = .98 and .71. There was no significant difference in the rate of sustained VT (3.0%vs. 3.2%, p = .85) but proximal lesions were more likely to develop CS (10.9%vs. 5.8%, p = .01), require IABP (7.3%vs.2.9%, p < .01) and TCP (6.3%vs. 2.6%, p = .01). Thirty‐day mortality was higher for proximal lesions (5.0%vs. 0.9%, p < .01) particularly for those with CS (35.3%vs. 10.0%, p = .05).ConclusionCulprit lesions located proximal to the origin of the last RV marginal artery had a higher rate of acute complications such as CS and mortality.
Smart drug delivery system based on silicone
Authors: Novotny Jana , Quarthal Dominik , Oetken Marco 
Published: September 2020

AbstractViele Lebewesen können sich energiesparend fortbewegen, unter schwierigen Bedingungen kommunizieren oder sich orientieren. Daher beschäftigt sich die Bionik damit diese ‚Eigenschaften‘ zu entschlüsseln und auf neue technische Konzepte zu übertragen [1]. So konnten Forscher des MPI [2] einen Milliroboter herstellen, der sich an Land gleich einer Raupe und im Wasser wie eine Qualle bewegt. Lu, Zhang et al. [3] konnten einen tausendfüßerartigen Roboter herstellen, welcher in der Lage ist, das Hundertfache seines Gewichts zu transportieren. Diese Milliroboter sollen zukünftig für den Medikamententransport im menschlichen Körper verantwortlich sein [4].Allerdings sind die eingesetzten Materialien teuer und die Apparaturen zur Bewegung der Roboter komplex. An der PH Freiburg gelang es jedoch, einen kostengünstigen Roboter aus Bausilikon herzustellen und mit einem Neodym‐Magneten zu bewegen. Der Artikel zeigt Experimente zur Herstellung und Anwendung dieses Roboters.
Putative dendritic correlates of chronic traumatic encephalopathy: A preliminary quantitative Golgi exploration
Authors: Warling Allysa , Uchida Riri , Shin Hyunsoo , Dodelson Coby , Garcia Madeleine E. , Shea‐Shumsky N. Beckett , Svirsky Sarah , Pothast Morgan , Kelley Hunter , Schumann Cynthia M. , Brzezinski Christine , Bauman Melissa D. , Alexander Allyson , McKee Ann C. , Stein Thor D. , Schall Matthew , Jacobs Bob 
Published: September 2020

AbstractChronic traumatic encephalopathy (CTE) is a neurodegenerative disorder that is associated with repetitive head impacts. Neuropathologically, it is defined by the presence of perivascular hyperphosphorylated tau aggregates in cortical tissue (McKee et al., 2016, Acta Neuropathologica, 131, 75–86). Although many pathological and assumed clinical correlates of CTE have been well characterized, its effects on cortical dendritic arbors are still unknown. Here, we quantified dendrites and dendritic spines of supragranular pyramidal neurons in tissue from human frontal and occipital lobes, in 11 cases with (Mage = 79 ± 7 years) and 5 cases without (Mage = 76 ± 11 years) CTE. Tissue was stained with a modified rapid Golgi technique. Dendritic systems of 20 neurons per region in each brain (N = 640 neurons) were quantified using computer‐assisted morphometry. One key finding was that CTE neurons exhibited increased variability and distributional changes across six of the eight dendritic system measures, presumably due to ongoing degeneration and compensatory reorganization of dendritic systems. However, despite heightened variation among CTE neurons, CTE cases exhibited lower mean values than Control cases in seven of the eight dendritic system measures. These dendritic alterations may represent a new pathological marker of CTE, and further examination of dendritic changes could contribute to both mechanistic and functional understandings of the disease.
Assessment of Problem‐Solving Skills and Inhibitory Control in Mice Using Water Escape Detour Test
Authors: Juszczak Grzegorz R. , Bobrowska Anna 
Published: September 2020

AbstractDespite the importance of emotional intelligence, its biological mechanism is still not well understood. For this reason, we have developed a rodent detour task which requires an animal to reach a highly desired object placed directly behind a transparent barrier that blocks the direct route to the target. This apparently simple task is highly dependent on the emotional control that is necessary to inhibit prepotent and counterproductive responses driven by the sight of a desired object. The water escape detour task designed for mice enables testing the ability to solve emotionally challenging problems, as well as identification of an impairment termed perseveration. Such a maladaptive reaction to a challenging situation is characterized by difficulty in terminating an unsuccessful response, leading to persistent repetition of inappropriate behavior. This issue is important because perseveration is associated with schizophrenia, drug abuse, and aging. © 2020 Wiley Periodicals LLC.Basic Protocol: Water escape detour taskSupport Protocol 1: Preparation of escape platformSupport Protocol 2: Preparation of the transparent barrierAlternate Protocol: Water escape detour task for testing acute effects
Conditions associated with the need for additional needle passes in ultrasound‐guided thyroid fine‐needle aspiration with rapid on‐site pathology evaluation
Authors: Zargham Ramin , Johnson Hannah , Anderson Scott , Ciolino Allison 
Published: September 2020

AbstractBackgroundRapid on‐site evaluation (ROSE) is a valuable tool for specimen adequacy assessment in thyroid ultrasound (US)‐guided fine‐needle aspiration (US‐guided FNA). To reduce the risk of nondiagnostic samples, additional needle passes may be needed at ROSE to ensure adequate sampling. Recommendations regarding the number of aspirates to ensure specimen adequacy are not well defined. Furthermore, there are limited data regarding nodule characteristics that may require increased sampling. In this study, we investigate conditions associated with requiring more than three needle passes during ROSE.MethodsA retrospective quality review of all patients who underwent US‐guided thyroid FNA by a single board‐certified radiologist over a 1‐year period was performed. A total of 122 patients were identified: 70 with three passes performed and 52 with more than three passes to achieve adequacy.ResultOur data demonstrate that large nodules (≥3 cm) were more likely than small nodules (≤1.1 cm) to require more than three passes to achieve adequacy. If a nodule was predominantly cystic or mixed cystic and solid, the sample was often adequate with only three passes. In cases of thyroiditis or nodules suspicious or diagnostic of neoplasia, there is a trend to require only three passes for adequacy.ConclusionOn the basis of the data presented in this study, cytopathologists should be prepared for the potential need to obtain additional needle passes in larger (≥3 cm) nodules and provide reassurance to patients that this is an anticipated finding for these larger nodules.
Early external‐environmental and internal‐health predictors of risky sexual and aggressive behavior in adolescence: An integrative approach
Authors: Ellis Bruce J. , Shakiba Nila , Adkins Daniel E. , Lester Barry M. 
Published: September 2020

AbstractExternal predictive adaptive response (PAR) models assume that developmental exposures to stress carry predictive information about the future state of the environment, and that development of a faster life history (LH) strategy in this context functions to match the individual to this expected harsh state. More recently internal PAR models have proposed that early somatic condition (i.e., physical health) critically regulates development of LH strategies to match expected future somatic condition. Here we test the integrative hypothesis that poor physical health mediates the relation between early adversity and faster LH strategies. Data were drawn from a longitudinal study (birth to age 16; N = 1,388) of mostly African American participants with prenatal substance exposure. Results demonstrated that both external environmental conditions early in life (prenatal substance exposure, socioeconomic adversity, caregiver distress/depression, and adverse family functioning) and internal somatic condition during preadolescence (birthweight/gestational age, physical illness) uniquely predicted the development of faster LH strategies in adolescence (as indicated by more risky sexual and aggressive behavior). Consistent with the integrative hypothesis, the effect of caregiver distress/depression on LH strategy was mostly mediated by worse physical health. Discussion highlights the implications of these findings for theory and research on stress, development, and health.
Cumulative stressors reduce the self‐regulating capacity of coastal ecosystems
Authors: Thrush Simon F. , Hewitt Judi E. , Gladstone‐Gallagher Rebecca V. , Savage Candida , Lundquist Carolyn , O’Meara Teri , Vieillard Amanda , Hillman Jenny R. , Mangan Stephanie , Douglas Emily J. , Clark Dana E. , Lohrer Andrew M. , Pilditch Conrad 
Published: September 2020

AbstractMarine ecosystems are prone to tipping points, particularly in coastal zones where dramatic changes are associated with interactions between cumulative stressors (e.g., shellfish harvesting, eutrophication and sediment inputs) and ecosystem functions. A common feature of many degraded estuaries is elevated turbidity that reduces incident light to the seafloor, resulting from multiple factors including changes in sediment loading, sea‐level rise and increased water column algal biomass. To determine whether cumulative effects of elevated turbidity may result in marked changes in the interactions between ecosystem components driving nutrient processing, we conducted a large‐scale experiment manipulating sediment nitrogen concentrations in 15 estuaries across a national‐scale gradient in incident light at the seafloor. We identified a threshold in incident light that was related to distinct changes in the ecosystem interaction networks (EIN) that drive nutrient processing. Above this threshold, network connectivity was high with clear mechanistic links to denitrification and the role of large shellfish in nitrogen processing. The EIN analyses revealed interacting stressors resulting in a decoupling of ecosystem processes in turbid estuaries with a lower capacity to denitrify and process nitrogen. This suggests that, as turbidity increases with sediment load, coastal areas can be more vulnerable to eutrophication. The identified interactions between light, nutrient processing and the abundance of large shellfish emphasizes the importance of actions that seek to manage multiple stressors and conserve or enhance shellfish abundance, rather than actions focusing on limiting a single stressor.