bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the safety and feasibility of metastasis-directed radiation and neoadjuvant hormone and radiation therapy followed by radical prostatectomy for treating oligometastatic prostate cancer: protocol for an open-label, dose-escalation, single-centre phase I clinical trial
Authors: Zhao Xianzhi , Xiao Yu-Tian , Yang Yue , Ye Yusheng , Chang Yifan , Jiang Lingong , Eftekhar Md , Ren Shancheng , Zhang Huojun 
Published: March 2020

Abstract
Background The systemic therapy is currently recommended for patients with oligometastatic prostate cancer, however the prognosis has not been satisfactory. Therefore, it is necessary to explore more effective treatment to improve the prognosis. Oligometastatic prostate cancer is a special subgroup in patients with advanced cancer. The paragrim of treatment is shifting to a more aggressive approach. Stereotactic body radiotherapy (SBRT) is an emerging treatment alternative for patients with oligometastases with minimal toxic effects. What’s more, accumulating studies have proved safety as well as feasibility of radical prostatectomy and local or metastasis-directed radiotherapy for oligometastatic patients. The aim of this phase I prospective trial is to demonstrate the early evidence of safety and feasibility of metastasis-directed radiation and neoadjuvant hormone and radiation therapy followed by radical prostatectomy for treating oligometastatic prostate cancer Methods The patients with oligometastatic prostate cancer received 1 month of neoadjuvant androgen deprivation therapy (ADT) followed by metastasis-directed radition and abdominal or pelvic radiotherapy. Then offer radical prostatectomy at the interval of 4-8 weeks after radiotherapy and adjuvant ADT for 2 years. The primary endpoints of the study are safety as assessed by CTCAE 5.0 grading scale and intraoperative and postoperative day-30 morbidity. Secondary endpoints include the positive rate of post-operative edge, biochemical progression-free survival (bPFS), postoperative continence and sexual function recovery, quality of life (QoL), overall survival (OS) and adverse reactions of ADT. Discussion This is the first, phase I trial assessing the safety and feasibility of metastasis-directed radiation and neoadjuvant hormone and radiation therapy followed by radical prostatectomy treatment for patients with oligometastatic prostate cancer. If positive, the results of this trial may help to design subsequent phase II trials exploring the role of metastasis-directed radiation and neoadjuvant hormone and radiation therapy followed by radical prostatectomy in the randomized controlled study.
New Technical Solution for Hybrid Turbochargers
Authors: Rares Chiriac , Chiru Anghel 
Published: March 2020

Abstract
Internal combustion engines have an efficiency of operating which can be exploit to increase its performance. Part of the residual gases can be recovered through the technical solutions such as turbocharging. The turbocharging solution is one of the most popular technical solutions for increasing the energy performance of internal combustion engines. For the turbocharging process it is used a turbocharger. The turbocharger can contribute also with new technical solutions to increase the energy performance of the internal combustion engines. One of the solutions proposed for the theoretical and experimental research is the hybrid turbocharger, which has a double function, namely to compress the fresh air for the internal combustion engine, and to generate electric energy for the electric engine of the vehicle both for consumption other to be stored in batteries. This article aims is to present the result of the experimental research of the hybrid turbocharger, simulate and validate the new solutions for increasing the energy performance of internal combustion engines through hybrid turbochargers using a coupled electric generator. The simulations will be made using the AMESim Sofware developed by Siemens to demonstrate the efficiency of the new solutions such as a hybrid turbocharger through calculations. The tests will be carried out with the test bed CIMAT. CIMAT test bed is a machine which provides higt pressure air which simulate the combustion gases of an engine. The pourpose of the CIMAT test bed is to rotate the hybrid turbocharger turbine and also the compressor wheel. More technical information about the hybrid turbocharger test will be presented in the article and also constructive details. Based on the technical information and input data in the first phase it will be made an application for the simulation and validation of the prototype to demonstrate the great potential of the turbocharger to produce also green energy.
Information seeking behavior and associated factors among construction workers towards HIV/AIDS in Debre Berhan town, Northeast Ethiopia, 2019
Authors: TESSEMA MULUKEN 
Published: March 2020

Abstract
Background: Information seeking behavior is the purposive seeking for information as a consequence of a need to satisfy some goals. Information is crucial for preventing the spread of the virus as there is no cure or vaccination for HIV/AIDS. The aim of this study is to assess information seeking behavior and associated factors among construction workers towards HIV/AIDS in Debre Berhan town, Northwest Ethiopia.Methods: Institution based cross-sectional study was conducted. A total of 705 construction workers were included in the study. Multistage sampling technique was used to select the study participants. A structured pretested interview questionnaire was used for data collection. The data were entered and cleaned in EPI info and exported in to SPSS version 16 statistical package for analysis. Binary logistic regression was used to identify associated factors. A p-value of 0.05 was taken as a cut off value for statistical significant association. Results: Out of 705 workers, 200(28.4%) were categorized as having inappropriate information seeking behavior towards HIV/AIDS. Comprehensive knowledge of HIV/AIDS [AOR=2.26, 95% CI: 1.47-3.50], workers who received HIV information from work place [AOR=1.52, 95% CI:1.00-2.29] and tested for HIV [AOR=1.81, 95% CI:1.19-2.73] were more likely to have appropriate information seeking behavior towards HIV/AIDS whereas female construction workers [AOR=0.39, 95% CI: 0.27-0.56] were less likely to have appropriate information seeking behavior towards HIV/AIDS.Conclusion: Appropriate information seeking behavior towards HIV/AIDS among construction workers was not satisfactory. Comprehensive knowledge of HIV, information received from work place, being tested for HIV and workers sex (gender) affects information seeking behavior towards HIV/AIDS. Work place HIV prevention and control strategy need to be implemented to increase appropriate information seeking behavior towards HIV/AIDS.
Viscoelasticity measured by shear wave elastography in a rat model of NAFLD: comparison with dynamic mechanical analysis
Authors: Pi Zhaoke , Wang Mengke , Lin Haoming , Guo Yanrong , Chen Siping , Diao Xianfen , Xia Hui , Liu Guoqiang , Zeng Jie , Zhang Xinyu , Chen Xin 
Published: March 2020

Abstract
Background: Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming one of the most common liver diseases. Ultrasound elastography has been used for the diagnosis of NAFLD. However, clinical research on steatosis by elastography technology has mainly focused on steatosis with fibrosis or non-alcoholic steatohepatitis (NASH), while steatosis without fibrosis has been poorly studied. Moreover, the relationship between liver viscoelasticity and steatosis grade is not clear. In this study, we evaluated the degree of liver steatosis in a simple steatosis rat model using shear wave elastography (SWE). Results: The viscoelasticity values of 69 rats with hepatic steatosis were measured quantitatively by SWE in vivo and validated by a dynamic mechanical analysis (DMA) test. Pathological sections were used to determine the steatosis grading for each rat. The results showed that the elasticity values obtained by the two methods followed the same trend, and the elasticity is significantly correlated with liver steatosis. The Pearson’s correlation coefficients indicate that elasticity obtained by SWE is positively linear correlated with DMA (r = 0.628, p = 7.85×10 -9 ) Conclusion: SWE might have the feasibility to be introduced as an auxiliary technique for NAFLD patients in clinical settings. However, the viscosity results measured by the two methods are significantly different because the two methods work in different frequency bands.
Factors associated with adherence to safe water chain practices among refugees in Pagirinya refugee settlement, Northern Uganda
Authors: Mugumya Thomas , Isunju John Bosco , Ssekamatte Tonny , Wafula Solomon Tsebeni , Mugambe Richard K. 
Published: March 2020

Abstract
Poor adherence to safe water chain practices is a major obstacle to consumption of safe drinking water. In refugee settings, adherence to safe water chain is critical in minimizing water-related diseases. Despite this, little is known about the level of adherence to safe water chain and associated factors, especially in emergency settings. In this study, we interviewed 400 household heads in Pagrinya refugee camp in Northern Uganda and assessed household level adherence to safe water chain practice and associated factors. Modified Poisson regression was used to model the association between adherence to safe water chain and independent variables. All households utilized improved water sources and 74.0% had high adherence to safe water chain. Having post-primary education and high level of knowledge about the safe water chain were positive predictors of high adherence to the safe water chain while round travel time exceeding 1 hour during water collection was negatively associated with high adherence. There is a need for awareness campaigns on safe water chain maintenance among refugees without any formal education. Constructing more water sources would also minimize round travel time during water collection and enable households to collect sufficient water that enables hygienic water storage and use.
A Novel Hybrid Filter/Wrapper Feature Selection Approach Based on Improved Fruit Fly Optimization Algorithm and Chi-square Test for High Dimensional Microarray Data
Authors: Yan Chaokun , Wu Bin , Ma Jingjing , Zhang Ge , Luo Junwei , Wang Jianlin , Luo Huimin 
Published: March 2020

Background:
Microarray data is widely utilized for disease analysis and diagnosis.
However, it is hard to process them directly and achieve high classification accuracy due to the
intrinsic characteristics of high dimensionality and small size samples. As an important data
preprocessing technique, feature selection is usually used to reduce the dimensionality of some
datasets.

Methods:
Given the limitations of employing filter or wrapper approaches individually for feature
selection, in the study, a novel hybrid filter-wrapper approach, CS_IFOA, is proposed for high
dimensional datasets. First, the Chi-square Test is utilized to filter out some irrelevant or redundant
features. Next, an improved binary Fruit Fly Optimization algorithm is conducted to further search
the optimal feature subset without degrading the classification accuracy. Here, the KNN classifier
with the 10-fold-CV is utilized to evaluate the classification accuracy.

Results:
Extensive experimental results on six benchmark biomedical datasets show that the
proposed CS-IFOA can achieve superior performance compared with other state-of-the-art
methods. The CS-IFOA can get a smaller number of features while achieving higher classification
accuracy. Furthermore, the standard deviation of the experimental results is relatively small, which
indicates that the proposed algorithm is relatively robust.

Conclusion:
The results confirmed the efficiency of our approach in identifying some important
genes for high-dimensional biomedical datasets, which can be used as an ideal pre-processing tool
to help optimize the feature selection process, and improve the efficiency of disease diagnosis.
Design and Development of 4-Bit Gray Code Counter Circuit Using Reversible Logic Gate
Authors: Maity Heranmoy , Sen Barnali , Verma Ishika , Biswas Arindam , Pal Anita , Bhattacharjee Anup K. 
Published: March 2020

Aim:
This paper proposed the design and development of 4-Bit Gray Code Counter Circuit
Using Reversible Logic Gate.

Methods:
The 4-Bit Gray Code Counter Circuit can be design using SAM gate, Feynman gate (FG),
double Feynman gate (DFG) and NOT gate. The proposed circuit is the combined application of 4-bit
binary asynchronous counter and 4-bit binary to gray code converter circuit.

Results:
The proposed gray code counter is designed using four no. of SAM gate, three no. of DFG,
one FG and seven reversible NOT gate. The QC, GO and CI of proposed circuit are correspondingly
30, 4 and 7.

Conclusion:
The novel reversible gray code counter have been designed using existing reversible logic
gate. The proposed gray code counter is designed using four no. of SAM gate, three no. of DFG, one FG
and seven reversible NOT gate. The QC, GO and CI of proposed circuit are correspondingly 30, 4 and 7.
A New Ecological HPLC Method for Determination of Vancomycin Dosage form
Authors: Aleixa do Nascimento Patrícia , Kogawa Ana Carolina , Salgado Hérida R.N. 
Published: March 2020

Aims:
To develop and validate a new ecological HPLC method for the determination of
vancomycin dosage form.

Background:
Vancomycin is an important antimicrobial. According to the literature, there are
many methods that use HPLC, but none of these methods follow the green analytical chemistry
principles.

Objective:
Therefore, a green analytical method to quantify vancomycin in lyophilized powder for
injectable solution by HPLC was developed.

Materials and Methods:
It uses less quantity of toxic solvents, minimizing the costs and optimizing
the time of analysis. Water + 0.1% acetic acid and ethanol (85:15, v/v), 0.5 mL min-1, and C18
column (15 cm) at 280 nm were used.

Results and Discussion:
The method was linear in the range of 40 to 140 μg mL-1, with a correlation
coefficient of 0.9998. It was selective when subjected to acid 0.1M, basic 0.01M, oxidative
0.3%, UV light and neutral degradation in a bath of 60 ºC for 8 hours. The precision of the method
was proved at intraday (RSD 1.08%), interday (RSD 0.47%) and intermediate levels (RSD
2.35%). It was accurate with a mean recovery of 100.19% and robust when changes were performed
in seven parameters of the method and analyzed by the Youden and Steiner test.

Conclusion:
The method can be applied to routine quality control of vancomycin lyophilized
powder for injectable solution as an ecological and sustainable alternative that contemplates the
green analytical chemistry and the current pharmaceutical analyses.
Stackelberg Game Analysis of Enterprise Operation Improvement Decision and Consumer Choice Behaviour
Authors: Zhang Gongliang , Sun Qian 
Published: March 2020

:
To explore the effective improvement of business decision-making, this paper takes consumers
as a utility factor in business decision-making. Under the assumption of maximizing the interests
of consumers and manager, it describes the problems and establishes Stackelberg game model,
which uses the heuristic algorithm of sensitivity to solve the business decision-making model of
two charging items with the number of consumers as N through calculation, and discussed the corresponding
strategies, hopes can provide decision-making reference for the managing of two charging
projects at the same time. The results show that for the operation with two charging items, the manager
shall decide whether to improve and the order of improvement according to the improvement
cost and the net utility after improvement.
Sedentary Work in Desk-Dominated Environments: A Data-Driven Intervention Using Intervention Mapping
Authors: Berninger Nathalie M , ten Hoor Gill A , Plasqui Guy , Kok Gerjo , Peters Gjalt-Jorn Ygram , Ruiter Robert A C 
Published: March 2020

Background
Since desk-dominated work environments facilitate sedentary behavior, office workers sit for 66% of their working days and only 8% succeed in interrupting their prolonged periods of sitting within the first 55 minutes. Yet stretches of long and uninterrupted sitting increase the likelihood of several chronic metabolic and cardiovascular diseases.

Objective
We therefore developed a computer-based app designed to interrupt periods of prolonged sitting among office employees.

Methods
When developing the intervention, we applied the intervention mapping protocol. This approach for the systematic design of theory and evidence-based behavior change programs consists of 6 steps: creation of a logic model of the problem, creation of a logic model of change, program design, program production, design of an implementation plan, and development of an evaluation plan.

Results
Working through all 6 steps has resulted in an individually adaptable intervention to reduce sedentary behavior at work. The intervention, UPcomplish, consists of tailored, half-automatized motivational components delivered by a coach. To register sedentary behavior, the VitaBit (VitaBit Software International BV) toolkit, a wearable accelerometry-based monitoring device, is used. Among others, UPcomplish includes personalized goal setting, tailored suggestions to overcome hurdles, and weekly challenges. The VitaBit toolkit supports the participants to monitor their behavior in relation to self-set goals.

Conclusions
Intervention mapping is a useful protocol not only for the systematic development of a comprehensive intervention to reduce sedentary behavior but also for planning program adherence, program implementation, and program maintenance. It facilitates obtaining the participation of relevant stakeholders at different ecological levels in the development process of the intervention and anticipating facilitators to and barriers of program implementation and maintenance.

Trial Registration
Netherlands Trial Register NL7503; https://www.trialregister.nl/trial/7503
Mental Health–Related Behaviors and Discussions Among Young Adults: Analysis and Classification
Authors: Rivas Ryan , Shahbazi Moloud , Garett Renee , Hristidis Vagelis , Young Sean 
Published: March 2020

BackgroundThere have been recurring reports of web-based harassment and abuse among adolescents and young adults through anonymous social networks.ObjectiveThis study aimed to explore discussions on the popular anonymous social network Yik Yak related to social and mental health messaging behaviors among college students, including cyberbullying, to provide insights into mental health behaviors on college campuses.MethodsFrom April 6, 2016, to May 7, 2016, we collected anonymous conversations posted on Yik Yak at 19 universities in 4 different states and performed statistical analyses and text classification experiments on a subset of these messages.ResultsWe found that prosocial messages were 5.23 times more prevalent than bullying messages. The frequency of cyberbullying messages was positively associated with messages seeking emotional help. We found significant geographic variation in the frequency of messages offering supportive vs bullying messages. Across campuses, bullying and political discussions were positively associated. We also achieved a balanced accuracy of over 0.75 for most messaging behaviors and topics with a support vector machine classifier.ConclusionsOur results show that messages containing data about students’ mental health–related attitudes and behaviors are prevalent on anonymous social networks, suggesting that these data can be mined for real-time analysis. This information can be used in education and health care services to better engage with students, provide insight into conversations that lead to cyberbullying, and reach out to students who need support.
Effects of a Web-Based Patient Portal on Patient Satisfaction and Missed Appointment Rates: Survey Study
Authors: Graham Timothy A D , Ali Samina , Avdagovska Melita , Ballermann Mark 
Published: March 2020

Background
Although electronic medical record (EMR)-tethered patient portals are common in other countries, they are still emerging in Canada.

Objective
We aimed to report user satisfaction and the effects of a patient portal on medical appointment attendance in a Canadian cohort of patients within our publicly funded health care system.

Methods
Two surveys were deployed, via email, at 2 weeks and 6 months following the first recorded patient portal access. Database audits of visit attendance were used to supplement and cross reference survey data.

Results
Between January 2016 and July 2018, 4296 patients accessed the patient portal. During the study, 28% (957/3421) consented patient portal users responded to one or more semistructured electronic surveys. Of respondents, 93% (891/957) reported that the patient portal was easy to use, 51% (492/975) reported it saved time when scheduling an appointment, and 40% (382/957) reported that they had to repeat themselves less during appointments. Respondents reported patient portal–related changes in health system use, with 48% (462/957) reporting avoiding a clinic visit and 2.7% (26/957) avoiding an emergency department visit. Across 19,968 visits in clinics where the patient portal was introduced, missed appointments were recorded in 9.5% (858/9021) of non–patient portal user visits, compared with 4.5% (493/9021) for patient portal users, representing a 53% relative reduction in no-show rates.

Conclusions
Early experience with an EMR-tethered patient portal showed strong reports of positive patient experience, a self-reported decrease in health system use, and a measured decrease in missed appointment rates. Implications on the expanded use of patient portals requires more quantitative and qualitative study in Canada.
Kajian Semiotika Pernikahan Karakter Virtual Hatsune Miku dan Akihiko Kondo
Authors: Sujatmiko Guguh 
Published: March 2020

Abstract—Akihiko Kondo and Hatsune Miku’s marriage ceremony attracted public attention. The marriage shows an unusual relationship between human and virtual character, the Actual world who got married to the Ideal world. This paper uses a qualitative method of the semiotic theory of Rholand Barthes. This paper _tries to describe the signs that are connected to both virtual characters and humans. The signs were dismantled to find out what codes and symbols that worked. The results show that the signs which were constructed into Hatsune Miku's character have naturalization of meaning, therefore the arose myths became ordinary as humans consume virtual signs continuously and endlessly. The signs become very important, the ideal world will be more interesting to be explored because it provides very broad opportunities in the signs development. Keywords: semiotic, virtual, character­
Abstrak—Pernikahan seorang lelaki bernama Akihiko Kondo dan Hatsune Miku cukup menarik perhatian masyarakat. Pernikahan tersebut menunjukkan hubungan yang tidak biasa antara manusia dalam dunia aktual yang menikahi karakter dalam dunia ideal. Penelitian ini menggunakan metode kualitatif dengan pendekatan teori semiotic dari Rholand Barthes. Penulis mencoba menguraikan tanda-tanda yang terhubung antara keduanya. Tanda-tanda tersebut dibongkar untuk mengetahui kode-kode dan simbol-simbol yang bekerja. Hasil menunjukkan bahwa tanda-tanda yang dikonstruksi menjadi karakter Hatsune Miku mengalami naturalisasi makna, sehingga mitos-mitos yang timbul menjadi hal yang biasa karena manusia mengonsumsi tanda virtual terus-menerus dan tiada akhir. Tanda menjadi hal yang sangat penting, dunia ideal akan semakin menarik untuk dieksplorasi karena memberikan kesempatan yang sangat luas dalam perkembangan tanda.
Kata kunci: semiotik, virtual, karakter