bluuebunny/crossref_metadata_2025_split huggingface dataset:
IN VITRO WOUND HEALING AND ANTIMICROBIAL PROPERTY OF COTTON FABRICS COATED OPTIMIZED SILVER NANOPARTICLES SYNTHESIZED USING PELTOPHORUM PTEROCARPUM LEAF EXTRACTS
Authors: ANNAMALAI P  , BALASHANMUGAM P  , KALAICHELVAN PT  
Published: December 2019

Objective: The present study was aimed to study at investigating the antibacterial potential of silver nanoparticles (AgNPs) coated cotton fabrics against different pathogens and also for their wound healing property using fibroblasts cells.
Materials and Methods: The leaf extracts of Peltophorum pterocarpum were used for the synthesis of AgNPs and were characterizing using ultraviolet-visible spectrophotometer, transmission electron microscopy, energy dispersive X-ray (EDX) spectroscopy, dynamic light scattering analysis, and zeta potential measurement. The AgNPs were coated on cotton fabrics and tested for their antibacterial efficacy using agar well diffusion method. The wound healing property of synthesized AgNPs was tested using fibroblast 3T3 cells.
Results: The plant extracts of P. pterocarpum were utilized for AgNPs. The optimum condition for synthesizing AgNPs was found to be 1 mg/ml plant concentration, 7 pH, 1 mM silver nitrate concatenation, and incubation temperature of 37°C. The shape of synthesized AgNPs was found to be spherical with an average size between 20 and 50 nm, and elemental silver peaks were confirmed by EDX spectrum. The cotton fabrics coated with AgNPs show good zone of inhibition against all the tested pathogens and the treated fabrics were also characterized using scanning electron microscope which reveals the presence of AgNPs on the fabrics. The scratch assay reveals that the AgNPs have good wound healing activity when tested against fibroblast 3T3.
Conclusion: The present results conclude that the synthesized AgNPs have good stability with potent antimicrobial activity when coated with cotton fabrics. The AgNPs also found to have good activity significant wound healing activity when tested using fibroblast cells.
ENCAPSULATION OF IBUPROFEN INTO SOLID LIPID NANOPARTICLES FOR CONTROLLED AND SUSTAINED RELEASE USING EMULSIFICATION SOLVENT EVAPORATION TECHNIQUE
Authors: WESLEY N OMWOYO  , MAKWENA J MOLOTO  
Published: December 2019

Objective: The objective of the study was to encapsulate ibuprofen (IBU) into solid lipid nanoparticles (SLNs) for enhanced dissolution and achieving a sustained and controlled release of the drug from the nanocarrier.
Methods: IBU loaded nanoparticles were prepared by emulsification solvent evaporation technique and characterized by Fourier Transform Infrared spectroscopy, Thermogravimetric Analysis, X-ray diffraction (XRD), and transmission electron microscopy. Release kinetics on the drug-loaded nanoparticles was carried out in phosphate buffer pH 6.8 using pharma test dissolution apparatus adopting shaking basket method at 37°C.
Results: The optimized IBU-loaded SLNs had a particle size of 76.40 nm, polydispersity index of 0.275, and zeta potential of −41.3 mV. The encapsulation efficiency (EE) and DL were 99.73% and 2.31%, respectively. The Fourier transform infrared spectroscopy (FTIR) spectra confirmed successful encapsulation of the drug inside the nanocarrier as only peaks responsible for the emulsifier and the binder could be identified. This corroborated well with XRD spectra which showed a completely amorphous state of the drug-loaded nanoparticles as compared to the crystalline nature of the pure drug. The IBU-SLNs showed a release profile of up to 8 h which is a great improvement from other reported works. The drug release pattern of IBU-SLNs was best fitted with Higuchi square root model and followed the Higuchi drug release kinetics. Korsmeyer-Peppas model confirmed a non-Fickian diffusion model for the release of the drug from the matrix system.
Conclusion: IBU-loaded SLNs were successfully prepared which had a sustained and controlled release. It was observed that the release of the drug from the matrix was diffusion controlled and time dependent.
ANTIHYPERTENSIVE EFFECT OF RUTIN: PHARMACOLOGICAL AND COMPUTATIONAL APPROACH
Authors: GANGA RAJU M  , PREM PRASAD GOUD  , SUVARCHALA REDDY NVL  
Published: December 2019

Objective: Phenolic compounds, such as flavonoids, have aroused great scientific interest due to their diverse pharmacological activities. Several studies suggested that flavonoids act as antihypertensive by inhibiting angiotensin-converting enzyme (ACE). In the present study, rutin, which is a citrus flavonoid, was evaluated for its antihypertensive activity using in vivo and in vitro models. Rutin was screened for in vitro assay procedures such as diphenylpicrylhydrazyl and nitroblue tetrazolium (NBT) for its antioxidant activity.
Methods: Its antihypertensive effect was investigated in Nω-Nitro-l-arginine methyl ester hydrochloride-induced hypertensive rats, and various parameters such as blood pressure and heart rate were measured; in vitro ACE inhibitory activity was carried out against ACE, aiming at a better understanding of the interaction of this flavonoid with the enzyme. To understand its binding affinity with the angiotensin-converting enzyme, molecular docking studies were carried out using ligand fit of Maestro 9.1 (Schrodinger Software Inc.). An in silico study of rutin was performed for the prediction of Absorption, distribution, metabolism and elimination (ADME) by utilizing a web-based program (www.swissadme.ch). This software computes physicochemical descriptors as well as predicts pharmacokinetic properties and drug-like nature of one or multiple small molecules (blood–brain barrier, cytochromes P450, and P-glycoproteins).
Results: Rutin at different dose levels of 200 and 400 mg/kg was tested, and the results have shown its antihypertensive, hypotensive, and negative chronotropic effects. Its antihypertensive activity might be mediated through angiotensin-converting enzyme inhibition (half maximal inhibitory concentration=66.01 μg/mL). In vitro studies also revealed the antioxidant activity of rutin, thus playing a major role in reducing oxidative stress associated with hypertension. The rutin showed optimum binding affinity with a molecular target (angiotensin-converting-enzyme) with the binding energy of −9.0 kcal/mol as compared to the standard (−6.3 kcal/mol). These results indicated that rutin is one of the potential ligands to treat hypertension. ADME results revealed the three violations of rutin (such as molecular mass, hydrogen donor, and acceptors) of five, and the standard captopril has got zero violations which clearly indicated the probability for its higher oral bioavailability.
Conclusion: From the above, it is concluded that rutin possesses antioxidant and antihypertensive activities.
SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL 5-ARYLIDENE-2-IMINO-3-(2- PHENYL- 1,8-NAPHTHYRIDIN-3-YL)THIAZOLIDIN-4-ONES
Authors: KUNDENAPALLY RAMALINGAM , DOMALA RAMESH , BATHULA SREENIVASULU 
Published: December 2019

Objectives: Nowadays, antimicrobial resistance represents one of the most significant challenges in the medical community. To overcome the problem, it requires the discovery of newer safe and effective molecules against infectious sickness. Synthesis and screening of 1,8-naphthyridines have attracted much attention over the decades since it plays a key role against the microorganisms.
Methods: 1,8-naphthyridine based 5-arylidene derivatives of thiazolidinone (3a-i) has been achieved by the cyclization reaction of 2-chloro-N- (2-phenyl-1,8-naphthyridin-3-yl)acetamide (1) with potassium thiocyanate in acetone followed by its Knoevenagel condensation reaction with appropriate arylaldehydes in ethanol. All the resulting products were confirmed using spectral and physicochemical data. Antibacterial activity was performed against different bacterial strains by agar disc diffusion method using ciprofloxacin as standard.
Results: Compound 3b showed tremendous antibacterial activity among all the tested compounds.
Conclusions: This study provides several advantages such as shorter reaction times, clean product, and good yields. Most of the final products possessed moderate to excellent antibacterial activity.
PROTECTIVE EFFECT OF ROTENONE AGAINST LIPOPOLYSACCHARIDE AND D-GALACTOSAMINE-INDUCED HEMATOTOXICITY
Authors: SAMRAT RAKSHIT  , ANJANI VERMA  , SATENDRA KUMAR NIRALA  , MONIKA BHADAURIA  
Published: December 2019

Objective: The aim of the present study was to investigate the protective efficacy of rotenone against lipopolysaccharide (LPS) and D-galactosamine (D-GalN)-induced altered hematology.
Methods: Hematotoxicity was induced by coinjection of LPS (50 μg/kg i.p.) and D-GalN (300 mg/kg i.p.). Rotenone (5, 10 and 20 mg/kg p.o.) was administered for 6 days as a pre-treatment. Blood was collected through puncturing the retro-orbital sinus to analyze blood parameter. Serum was separated to analyze glucose, triglyceride, and cholesterol.
Results: The present study revealed decreased in red blood cells, platelets, hemoglobin, and hematocrit value while a significant increase in white blood cells, lymphocyte, and monocytes were observed in LPS and D-GalN treated rats. LPS and D-GalN administration significantly decrease glucose level while serum lipid profile (triglycerides and cholesterol level) were increased significantly at 5% level of significance. LPS and D-GalN-induced altered hematological and serological variables were restored toward control by rotenone pretreatment for 6 days in dose-dependent manner.
Conclusion: It can be said that LPS and D-GalN administration resulted in alteration of various hematological parameters and rotenone at 20 mg/kg dose restored significant alteration toward control due to the presence of antioxidant activity of rotenone.
THE ROLE OF SELENIUM MICRONUTRIENTS AS ANTIOXIDANTS IN EXPOSURE TO E-CIGARETTE SMOKE
Authors: RIVAN VIRLANDO SURYADINATA  , MERRYANA ADRIANI  , SANTI MARTINI  , SRI SUMARMI  , BAMBANG WIRJATMADI  
Published: December 2019

Objective: E-cigarette products have resulted in various controversies concerning their posed impacts on health. Some argue that exposure to e-cigarette smoke could improve free radicals in the body; thus, it causes harming impacts on health. Peroral selenium (Se) administration can increase superoxide dismutase (SOD) and glutathione peroxidase (GPx) serving as antioxidants in the body.
Methods: This research is an experimental study aiming to analyze the effectiveness of Se to decrease free radical due to exposure to e-cigarette smoke as one of the preventive actions. The research was carried out to male Wistar rats with exposure to e-cigarette smoke and peroral Se intake with different time and duration of administration.
Results: Research results showed a decrease of antioxidant SOD and GPx in the administration of exposure to e-cigarette smoke, and they gradually increased after Se administration (p=0.000). Meanwhile, the malondialdehyde level was inversely proportional compared to antioxidant SOD and GPx.
Conclusion: Se is a micronutrient that can reduce free radicals due to exposure to e-cigarette smoke through enhancement of antioxidant enzymes such as SOD and GPx.
The 1-year economic burden of community-acquired pneumonia (CAP) initially managed in the outpatient setting in the USA
Authors: Divino Victoria , Schranz Jennifer , Early Maureen , Shah Hemal , Jiang Miao , DeKoven Mitch 
Published: December 2019

Aim:
To assess the annual economic burden of community-acquired pneumonia (CAP) initially managed in the outpatient setting.
Patients & methods:
Patients with an outpatient diagnosis of CAP between January 2012 and December 2016 were identified from the IQVIA (Danbury, CT & Durham, NC, USA) Real-World Data Adjudicated Claims – US Database. All-cause and CAP-related healthcare resource utilization and costs were assessed over the 1-year follow-up. Generalized linear model examined adjusted total cost.
Results:
Among 256,916 patients with outpatient CAP, a tenth (10.6%) had ≥1 hospitalization and, of these, 18.7% had ≥1 CAP-related hospitalization. The mean total cost per patient was US$14,372; 10.9% was CAP-related and 26.1% was due to inpatient care. The adjusted mean total all-cause cost was US$13,788.
Conclusion:
Patients with outpatient CAP incurred a substantial annual economic burden.
Knowledge, Attitude and Practice of Self Medication: A Cross-sectional Study among Yemeni Health Profession Students
Authors: Alshakka Mohammed , Al-Abd Nazeh , Alkubati Sana S. 
Published: December 2019

Self-medications practice is increasing widely. It is expected to be higher in health students due to their awareness and knowledge of diseases and medicines.
The Aim of the study to assess the self-medications among the first year students of health science facilities in Aden University, Yemen.
Cross sectional study was conducted using Questionnaire from previous study served as the data collection instrument among first year students who were available during study period.
Descriptive statistics was used to describe the frequency of variable
A total of 231 out of 250 questionnaires were completed and returned, which gives the response rate of 92.4%. 119 (51.5 %) of respondents were male and 112(48.5%) of them were female. Approximately 69 (29.9 %) of respondents had no Knowledge on definition of Self-medication at all, only 25 (10.8 %) had very much knowledge about it , majority of respondents 82 (68.9 %) stated that they did so because the illness were minor were among the most reasons for self-medication, followed by prior experiences with the previous episode and treatment 72 (60.5 %), emergency use 54(45.4 %), quick relief 46 (38.7%) , cost effectiveness 42 (35.3 %) and 39 (32.8 %) of respondents reported that lack of time to go for consultation
. The most common sources of information used by the respondent were text books and pharmacists. The attitude was positive towards self-medication and favored self-medication saying that it was acceptable.
Self-medication habits were common among first year students of faculty of Medicine and Health Sciences at Aden University in Yemen. An urgent and rapid intervention should be made to promote health awareness of the self-medication among students because the percentages of using antibiotics and other classes of medicines are alarming. Students must be educated about the potential hazard of using medicines without physician advices and their serious adverse reactions. The Ministry of Health and Population must enact laws regulating the dispensing of medicines from pharmacies
Políticas de promoción a la agricultura familiar en la zona periurbana de Río Gallegos (2007 – 2017). Un análisis desde el punto de vista de los derechos humanos
Authors: Musci Carolina , Mansilla Claudia , Lipka Gina , Cárcamo Yamile 
Published: December 2019

El objetivo del trabajo es identificar y valorar la política pública vigente en la ciudad de Río Gallegos, en relación con la promoción de la agricultura familiar entre los años 2007 – 2017. La indagación identifica los programas y planes vigentes durante ese período, sus objetivos y las instituciones involucradas en esta actividad. Para ello se realizó un relevamiento de planes, programas y documentos institucionales, fichaje y sistematización de la información obtenida para su posterior análisis. Este análisis se orienta a determinar la pertinencia de la oferta de la política pública para alcanzar las metas definidas por el Objetivo de Desarrollo Sostenible 2: Hambre cero, de la Agenda de Desarrollo Sostenible 2030, y a calificarla en relación con algunos indicadores de Capacidad estatal propuestos por el Grupo de Trabajo para la medición del Protocolo de San Salvador. De esta manera se pretende generar conocimiento útil, respaldado en información empírica, que potencialmente ayude a mejorar la formulación de propuestas en las agendas de gobierno municipal y provincial, que sean cada vez más acordes con los estándares que definen los Pactos y Tratados internacionales para el cumplimiento efectivo de los derechos humanos.
Políticas públicas, educación secundaria y desigualdad. Un estudio en zona norte de Santa Cruz
Authors: Almada María Laura , Bang Lucas , Cestare Mariela , Grinberg Silvia , Pérez Andrés , Venturini María Eugenia , Villagran Carla 
Published: December 2019

El papel del Estado es, sin duda, clave en lo que refiere al despliegue de los recursos que una sociedad requiere para atender las demandas, contingencias y necesidades de la población. El Estado toma posición respecto de las cuestiones públicas que afectan el bienestar de la ciudadanía en escenarios donde esas demandas no sólo no son transparentes sino que son objeto de lucha. La pregunta por las políticas públicas refiere a la secuencia de posiciones y acciones de las agencias gubernamentales y burocráticas que actúan en nombre del Estado con relación a esas demandas que conforman la agenda pública (Oszlak, 2006). Es en este marco de debates que esta investigación se propuso el estudio de las políticas públicas de la educación secundaria. Específicamente nos hemos ocupado de la puesta en acto (Ball, Maguire & Braun, 2012; Bocchio, Grinberg y Villagran, 2016; Villagran, 2018) de un conjunto de políticas en su devenir institucional atendiendo a la desigualdad y fragmentación urbana en la zona norte de Santa Cruz, especialmente Caleta Olivia. Este trabajo involucró tres momentos de investigación: 1) la georeferencia de la información estadística en el espacio urbano de los establecimientos educativos por radios censales y Necesidades Básicas Insatisfechas (NBI) según Censo Nacional de Población, Hogares y Viviendas 2010, que dieron lugar a la confección de mapas socioeducativos mediante QGis; 2) encuestas a estudiantes y 3) entrevistas en profundidad en algunas escuelas seleccionadas según criterios de desigualdad urbana y escolar. En este trabajo nos enfocamos en las políticas públicas en educación secundaria y su puesta en acto de la vida escolar, atendiendo a la desigualdad urbana y a haciendo eje en las visiones de los estudiantes. En esta primera etapa del trabajo realizado nos hemos ocupado, dado su impacto en la vida escolar en los últimos cinco años, de algunas dimensiones de esas políticas que refieren a las nuevas regulaciones en la escolaridad secundaria y más específicamente en las dinámicas de las escuelas emplazadas en las áreas con mayor NBI de la localidad.
Pemanfaatan Media Pembelajaran Fisika Berbasis Android Bagi Guru-Guru Fisika SMA
Authors: Sujanem Rai , Suswandi Iwan , Yasa Putu 
Published: December 2019

Tujuan pengabdian masyarakat penerapan Ipteks ini, yaitu: (1) guru-guru fisika dapat memproduksi media pembelajaran fisika berbasis android (mpfiba), dan (2) mpfiba tersebut dapat diimplementasikan di kelas. Mitra pengabdian ini adalah 10 orang guru fisika SMA di kecamatan Kuta dan Kuta Utara kabupaten Badung. Metode yang digunakan adalah metode pelatihan, penugasan, dan pendampingan. Pada saat pelatihan, para peserta dibekali konsep dasar mpfiba, dan latihan membuat mpfiba. Pada saat penugasan, peserta diberikan form isian untuk merancang media yang dilengkapi tema atau topik, landasan teori, video, simulasi, dan soal kuis. Pada saat pendampingan, peserta mendiskusikan rancangan yang telah dibuat, narasumber mengklarifikasi, dan memberikan bimbingan dalam pembuatan mpfiba sampai terwujud media mpfiba yang siap untuk diimplementasikan. Pada saat implementasi mpfiba di kelas, narasumber melakukan observasi dan evaluasi untuk dianalisis sejauhmana efektivitas mpfiba dalam menunjang proses belajar mengajar Fisika. Berdasarkan hasil evaluasi diperoleh, yaitu: (1) para peserta pelatihan telah dapat memproduksi mpfiba dengan kriteria sangat baik sebanyak 20%, dan kriteria baik sebanyak 80%. (2) peserta telah dapat mengimplementasikan mpfiba di kelas. Dengan demikian, peserta pelatihan telah dapat memproduksi mpfiba serta pemanfaatan mpfiba untuk diimplementasikan dalam pembelajaran fisika. Kata Kunci: Media Pembelajaran Fisika, Android
Evaluation of physiological preparedness for reproductive function of domesticated beluga females and females grown from eggs in artificial conditions
Authors: Geraskin Petr Petrovich , Kovaleva Angelika Vyachislavovna , Grigoriev Vadim Alekseevich , Firsova Angelina Valerievna , Yaitskaya Marina , Vetrova Vera 
Published: December 2019

The article highlights the problem of significant reducing the number of beluga at the beginning of the XXI century, which resulted in restoring its population artificially. The formation of repair and brood stocks is slowing down due to a significant shortage of producers of natural generation. Artificial reproduction of beluga is currently carried out due to domestication of fish, as well as by growing mature individuals on “from eggs to eggs” principle. Producers grown in the hatcheries often have metabolic disturbances, signs of physiological exhaustion, and a modified biochemical composition of oocytes. All these deteriorate the reproductive functions of the producers. There have been presented the results of studying physiological preparedness of beluga producers to spawning campaign carried out by the Caspian branch FSBO “Glavrybvod” at the Sergievsky sturgeon hatchery. The objects of the study were females caught in the natural environment and domesticated in the hatchery, as well as sixteen-eighteen-year-old females from their own broodstock. Physiological readiness for spawning was assessed by a complex of physiological and biochemical parameters of blood and the amount of accumulated plastic and energy substances
in oocytes in the form of proteins and lipids. It was revealed that domesticated females were better prepared for pituitary injections than females from the broodstock. This was justified by both physiological and biochemical parameters, as well as by the coefficient of polarization of oocytes. Eggs of females grown in the hatchery conditions are smaller (1.3 times smaller) and the number of triglycerides in them is 4.35 times less than in those of domesticated fish. In addition, the accumulation of protein and lipids by oocytes differs greatly in broodstock female species due to heterogeneity of their functional state.
La formación por competencias en el programa de pedagogía infantil de la facultad de educación de la universidad surcolombiana: realidad o buenas intenciones
Authors: Guevara Salazar Leidy Ximena 
Published: December 2019

Las demandas de la sociedad del conocimiento, que implica una utilización de los saberes en pro de una calidad de vida mejor y más equitativa, comprome­ten más a las universidades a vincular sus programas con el sector productivo, de modo que resulte relevante la incorporación de profesionales competentes en el campo laboral. Por tal razón, las políticas actuales de educación han exi­gido que se forme por competencias, concepto que se asume como requisito para obtener el registro calificado y la acreditación de calidad de los programas académicos ofrecidos; por esto se hace necesario que los programas académi­cos cumplan con las condiciones de calidad establecidas por la ley, y que las instituciones logren demostrar su impacto en la formación de los estudiantes, convirtiéndolos en profesionales idóneos.
Con la intención de responder a lo anterior, la Universidad Surcolombiana ha realizado avances significativos en este aspecto, a la fecha, la institución ha logrado un mejoramiento significativo en la realización de sus funciones misio­nales, evidente en la acreditación de alta calidad de los programas de Medicina, Enfermería, Educación Física, Contaduría Pública, Lenguas Modernas e Ingenie­ría de Petróleos, Comunicación Social y Periodismo, Ingeniería Agrícola y Administración de Empresas y en el fortalecimiento y consolidación de grupos de investigación (semilleros, jóvenes investigadores y equipos de investigación) y proyección social.