bluuebunny/crossref_metadata_2025_split huggingface dataset:
La foi est-elle encore possible ?
Authors: Colin Dominique 
Published: April 2020

Dans nos sociétés, le discours chrétien semble de plus en plus insignifiant. Il faut alors se poser la question : « Qu’est-ce que croire ? » Revenant aux fondamentaux de la foi chrétienne, on perçoit sa radicalité critique à l’égard de la « suffisance » du monde. La foi renvoie à l’espérance qui crée du possible.
Promenons-nous dans les bois. Quid de l’apport de l’étude dendro-archéologique des charpentes anciennes à l’histoire de l’environnement dans le Massif armoricain ?
Authors: Olivier Corentin 
Published: April 2020

Le Massif armoricain de la fin du Moyen Âge et du début de l’Époque moderne est richement pourvu d’édifices gothiques. Peu d’entre eux sont connus pour leur charpente. Ces structures renferment pourtant bon nombre de renseignements. La dendrochronologie peut ainsi contribuer à la datation des monuments. Mais la charpente présente aussi l’avantage de nous éclairer sur quelques aspects de la ressource en bois d’œuvre utilisée. Au travers d’exemples archéologiques encore en place nous essaierons de savoir dans quelle mesure l’étude des charpentes anciennes peut aider à la connaissance des forêts et de leur exploitation. Pour ce faire, les informations issues des sources écrites seront confrontées aux observations dendro-archéologiques des bois de construction ainsi qu’aux données dendro-chronologiques. Entre la fin du Moyen Âge et l’époque moderne, le chêne est omniprésent parmi les ouvrages de charpenterie et témoigne du développement progressif du système bocager.
De l’estran à l’assiette : exemples de l’exploitation des invertébrés marins et terrestres par les populations monastiques au Moyen Âge et à l’époque moderne
Authors: Le Goff Laura 
Published: April 2020

Les établissements monastiques, du fait de l’observance de la règle, sont des lieux de consommation privilégiés des ressources halieutiques. Les invertébrés marins, considérés au Moyen Âge comme des poissons, ont alors pu représenter pour les communautés littorales un apport significatif à leur régime alimentaire. Cet article s’appuie sur l’étude de trois sites en particulier : l’abbaye de Landévennec et les prieurés de Charron et de Saint-Vivien. Les résultats des études archéomalacologiques y sont mis en regard des sources textuelles disponibles pour la période. Nous abordons tout d’abord la question des modes de collecte, des territoires exploités, puis les techniques employées et le choix des espèces consommées. Ensuite, nous nous intéressons au point central de cet article, soit les modes de consommation de ces invertébrés marins, en nous attardant en particulier sur les huîtres plates, les moules et les patelles, mais aussi terrestres, avec un focus sur les escargots. Enfin, la dernière partie aborde un usage méconnu des coquilles : leur réemploi en tant que matériau.
Observer la guerre depuis la gare : le cas de la Bretagne, région de l’arrière (1914-1921)
Authors: Lagadec Yann 
Published: April 2020

En février 1919, c’est face à la gare, à Nantes, que les autorités civiles et militaires organisent les festivités marquant le retour du 265e RI, le régiment de réserve cantonné dans la ville. Le lieu de ces cérémonies est éminemment symbolique : en célébrant ici ce retour, la population nantaise semble venir refermer la parenthèse ouverte en août 1914 au même endroit, lorsque les réservistes avaient embarqué dans les trains en direction de la frontière.Tout au long de ces cinq années, y compris en cette région de l’arrière qu’est avant tout la Bretagne, c’est en effet, en bien des villes, grandes ou petites, dans la gare que bat le pouls de la guerre. Départ des troupes mobilisées au cours de l’été 1914 puis des renforts régulièrement envoyés au front, arrivée des prisonniers allemands ou des blessés français soignés dans les nombreux hôpitaux temporaires, accueil des réfugiés de Belgique ou du Nord de la France, transit des troupes britanniques, américaines mais aussi russes ou portugaises, va-et-vient des permissionnaires, manifestations du printemps 1917, chargement des denrées réquisitionnées pour l’armée : la gare constitue, pour toutes ces raisons, un excellent observatoire de la guerre telle qu’elle fut vécue ici, sorte de sas par lequel la guerre pénètre en une zone de l’arrière moins exposée tout en l’alimentant en retour.
Een einde aan ondermijning
Authors: Boutellier Hans , van Steden Ronald , Eski Yarin , Boelens Mauro 
Published: April 2020

An end to undermining – On the rise and effect of a new security strategy
Undermining has become a buzz-word in Dutch politics and security governance. On national and local level there is great concern about the disappearing lines between the legal and illegal world, which affects the democratic order and rule of law in the Netherlands. Hence, everything possible should be done in order to combat the creeping threat of undermining. However, what is undermining actually? And why has the concept become so popular now? In this contribution, the authors will consider those and other relevant key questions about the rise and effect of the undermining concept to provide more conceptual clarity. By critically reflecting on undermining as a speech act, that is ‘underminization’ (cf. securitization), and based on empirical research, the authors suggest that there are two discourses at work that hinder the effectivity of the concept: one is specifically focused on the drugs industry with its illegal activities and one broadens the concept into unlawful and undesired developments that interfere with societal stability. The authors conclude that the concept of undermining may mobilize at policy level, yet seems to paralyze at operational level.
Non-pharmacological Management of Procedural Pain in Children: Health Worker’s Approach at a Tertiary Health Facility, Southern Nigeria
Authors: Eke G. K. , Ide L. E. Yaguo 
Published: April 2020

Introduction: Pain is one of the most recurrent complaints obtainable in paediatric settings especially while carrying out procedures. The emergency section is a very tasking place for children. Hence it is important for health care workers to follow a child focussed or individual methods in their assessment and management of pain and painful procedures.
Aim: To determine health workers’ approach towards non-pharmacological management of procedural pain in children at the University of Port Harcourt Teaching Hospital (UPTH).
Methods: This descriptive cross-sectional study was carried out between November 2019 and January 2020. A semi-structured questionnaire was used to retrieve information on biodata, knowledge and practice of non -pharmacological management of procedural pain in children. Data was entered into Microsoft Excel spread sheet and analysed using Statistical Package for Social Sciences version 21.
Results: Respondents in this study included 25(24.8%) physicians and 61(60.4%) nurses. Forty-four respondents (43.5%) had more than 10 years’ work experience. Self-development 59 (58.4%) was the most common source of knowledge of paediatric pain management. Fourteen (13.9%) respondents knew the appropriate time of applying non-pharmacological measures of which distraction was the most common strategy mentioned (n=85, 84.2%) and used (36%). Nurses were significantly more knowledgeable about non-pharmacological methods of pain management in children (p= .000).
Conclusion: There are gaps in knowledge and practice of clinicians concerning use of non-pharmacological interventions in the management of procedural pain in children. Development of a standard protocol would be an asset. There is need for necessary tools, and institutional commitment to adequate pain relief for children in our institution.
Comparative Study of Diode Laser versus Diathermy in Soft Tissue Surgical Procedures of Oral Cavity
Authors: Patil Chaitra , Srinath Narasimhamurthy , DN Umashankar , Kumar Mahesh 
Published: April 2020

Aims and Objectives: To evaluate wound healing and patient’s comfort after oral soft tissue surgical procedures performed by diode laser in comparison with diathermy.
Methods: This study includes 20 patients requiring oral soft tissue surgical procedures are randomly categorized into group A and group B of 10 patients each. Group A patients will undergo diathermy and group B patients will undergo laser therapy. Clinical assessment and photographs of patients will be done preoperatively and postoperatively on 1st day, 3rd day, 7th day, 2nd week and 4th week. Evaluation of postoperative bleeding, pain, infection and healing will be carried out.
Results: At the end of the study the assessment of parameters such as bleeding, swelling, wound healing, presence of infection were approximately similar in both the treatment methods to be insignificant, 70% of the patients included in this study under the laser group were very satisfied with the procedure & the pain experience by the patients in the same group was comparatively less, when compared to the diathermy group.
Conclusion: The observations suggest that both the treatment options were effective although laser proves better in terms of minimal bleeding, pain, reduced swelling, faster healing and patient’s comfort. Further research and a longer follow up period is desirable for a definitive conclusion.
Realizing Cancer Precision Medicine by Integrating Systems Biology and Nanomaterial Engineering
Authors: Joo Jae Il , Choi Minsoo , Jang Seong‐Hoon , Choi Sea , Park Sang‐Min , Shin Dongkwan , Cho Kwang‐Hyun 
Published: April 2020

AbstractMany clinical trials for cancer precision medicine have yielded unsatisfactory results due to challenges such as drug resistance and low efficacy. Drug resistance is often caused by the complex compensatory regulation within the biomolecular network in a cancer cell. Recently, systems biological studies have modeled and simulated such complex networks to unravel the hidden mechanisms of drug resistance and identify promising new drug targets or combinatorial or sequential treatments for overcoming resistance to anticancer drugs. However, many of the identified targets or treatments present major difficulties for drug development and clinical application. Nanocarriers represent a path forward for developing therapies with these “undruggable” targets or those that require precise combinatorial or sequential application, for which conventional drug delivery mechanisms are unsuitable. Conversely, a challenge in nanomedicine has been low efficacy due to heterogeneity of cancers in patients. This problem can also be resolved through systems biological approaches by identifying personalized targets for individual patients or promoting the drug responses. Therefore, integration of systems biology and nanomaterial engineering will enable the clinical application of cancer precision medicine to overcome both drug resistance of conventional treatments and low efficacy of nanomedicine due to patient heterogeneity.
Synthesis of Amides‐Functionalized POPs‐Supported Nano‐Pd Catalysts for Phosphine Ligand‐Free Heterogeneous Hydroaminocarbonylation of Alkynes
Authors: Wang Hongli , Yuan Hangkong , Wang Xinzhi , Zhao Jian , Wei Dongcheng , Shi Feng 
Published: April 2020

AbstractDevelopment of an approach for synthesis of efficient heterogeneous catalyst toward carbonylation reaction remains a challenge. Herein, we report our results of design and precise synthesis of amide‐functionalized porous organic polymers (POPs) supported nano‐Pd, and its applying in the first example of heterogeneous palladium‐catalyzed hydroaminocarbonylation of alkynes under phosphine ligand‐free conditions. A wide range of terminal alkynes and amines with various functional groups are smoothly converted into the corresponding branchedα,β‐unsaturated amides in moderate to good yields with high regioselectivity. The good catalytic performance of amides‐functionalized POPs supported nano‐Pd catalyst should be attributed to fine regulation of the catalytically active sites of the heterogeneous catalyst at the molecular level. The present study provided meaningful insights to design heterogeneous catalysts for phosphine ligand‐free carbonylation reaction.magnified image
Manipulating Molecular Structure and Morphology to Invoke High‐Performance Sodium Storage of Copper Phosphide
Authors: Hu Zhe , Liu Qiannan , Lai Weihong , Gu Qinfen , Li Lin , Chen Mingzhe , Wang Wanlin , Chou Shu‐Lei , Liu Yong , Dou Shi‐Xue 
Published: April 2020

AbstractCopper is used as current collector in rechargeable ion batteries due to its outstanding electronic conductivity and low cost. The intrinsic inactivity of copper, however, makes it a poor candidate for an electrode material without further structural modification. To fully utilize its high electronic conductivity, herein, the incorporation of heterogeneous phosphorus combined with building a unique 3D hollow structure is proposed. The as‐prepared copper phosphide hollow nanocubes deliver a stable capacity of 325 mAh·g−1 at 50 mA·g−1 and fast charging and discharging via pseudocapacitance behavior. The outstanding electrochemical performance is attributed to the synergetic effects of high electronic conductivity of copper and the high sodium storage capability of phosphorus. In addition, this facile synthesis method is also easily scaled up for practical applications. Thus, copper phosphide is a promising anode material for sodium ion batteries.
Conductive Li3.08Cr0.02Si0.09V0.9O4 Anode Material: Novel “Zero‐Strain” Characteristic and Superior Electrochemical Li+ Storage
Authors: Liang Guisheng , Yang Liting , Han Qing , Chen Guanyu , Lin Chunfu , Chen Yongjun , Luo Lijie , Liu Xianhu , Li Yuesheng , Che Renchao 
Published: April 2020

Abstract“Zero‐strain” compounds are ideal energy‐storage materials for long‐term cycling because they present negligible volume change and significantly reduce the mechanically induced deterioration during charging–discharging. However, the explored “zero‐strain” compounds are very limited, and their energy densities are low. Here, γ phase Li3.08Cr0.02Si0.09V0.9O4 (γ‐LCSVO) is explored as an anode compound for lithium‐ion batteries, and surprisingly its “zero‐strain” Li+ storage during Li+ insertion–extraction is found through using various state‐of‐the‐art characterization techniques. Li+ sequentially inserts into the 4c(1) and 8d sites of γ‐LCSVO, but its maximum unit‐cell volume variation is only ≈0.18%, the smallest among the explored “zero‐strain” compounds. Its mean strain originating from Li+ insertion is only 0.07%. Consequently, both γ‐LCSVO nanowires (γ‐LCSVO‐NW) and micrometer‐sized particles (γ‐LCSVO‐MP) exhibit excellent cycling stability with 90.1% and 95.5% capacity retention after as long as 2000 cycles at 10C, respectively. Moreover, γ‐LCSVO‐NW and γ‐LCSVO‐MP respectively deliver large reversible capacities of 445.7 and 305.8 mAh g−1 at 0.1C, and retain 251.2 and 78.4 mAh g−1 at 10C. Additionally, γ‐LCSVO shows a suitably safe operating potential of ≈1.0 V, significantly lower than that of the famous “zero‐strain” Li4Ti5O12 (≈1.6 V). These merits demonstrate that γ‐LCSVO can be a practical anode compound for stable, high‐energy, fast‐charging, and safe Li+ storage.
Adjusting corn nitrogen management by including a mineralizable‐nitrogen test with the preplant and presidedress nitrate tests
Authors: Clark Jason D. , Fernández Fabián G. , Veum Kristen S. , Camberato James J. , Carter Paul R. , Ferguson Richard B. , Franzen David W. , Kaiser Daniel E. , Kitchen Newell R. , Laboski Carrie A. M. , Nafziger Emerson D. , Rosen Carl J. , Sawyer John E. , Shanahan John F. 
Published: April 2020

AbstractThe anaerobic potentially mineralizable N (PMN) test combined with the preplant (PPNT) and presidedress (PSNT) nitrate tests may improve corn (Zea mays L.) N fertilization predictions. Forty‐nine corn N response experiments (mostly corn following soybean [Glycine max (L.) Merr.]) were conducted in the U.S. Midwest from 2014–2016 to evaluate the ability of the PPNT and PSNT to predict corn relative yield (RY) and N fertilizer over‐ and under‐application rates when adjusted by PMN. Before planting and N fertilization, PPNT (0–30, 30–60, and 60–90 cm) and PMN (0–30 cm) samples were obtained. In‐season soil samples were obtained at the V5 development stage for PSNT (0–30, 30–60 cm) in all N rate treatments and PMN (0–30 cm) in only the 0 and 180 kg N ha−1 preplant N treatments. Increasing NO3–N sampling depths beyond 30 cm with or without PMN improved RY predictability marginally (R2 increase up to 0.20) and reduced over‐ and under‐application frequencies up to 14%. Including PMN (preplant only) with PPNT or PSNT improved RY predictability minimally (R2 increase up to 0.10) only for coarse‐ and medium‐textured soils, but N fertilizer over‐ and under‐application frequencies were not substantially reduced (≤12%). These marginal improvements in RY predictability and N fertilizer over‐ and under‐application frequencies, regardless of the variables used (e.g., fertilization, sampling depth, soil texture, and growing degree‐day categories), demonstrate that including PMN with soil NO3–N alone does not improve corn N fertilization need predictions enough to recommend their use.
Caregiver‐reported clinical characteristics and the burden associated with Kabuki syndrome
Authors: Theodore‐Oklota Christina , Egan Shayna , Paulich Maggie , Evans Christopher J. , Hartman Deborah S. , Hoffman Deborah L. , Björnsson Hans T. 
Published: April 2020

AbstractKabuki syndrome is a genetic disorder that can affect multiple body systems and manifest as congenital abnormalities and both developmental and socio‐emotional delays. The condition is largely unknown by most primary care physicians and has no available treatment other than symptomatic management. This research sought to obtain caregiver‐reported data about the experience of living with and caring for someone with Kabuki syndrome to fill a gap in the available literature. Fifty‐seven caregivers participated in an online survey and reported that Kabuki syndrome affected their children in a wide variety of ways, including a high frequency of visits to various healthcare professionals. Caregivers reported their child experienced problems with hearing, eating, eyes, mouth, immune system, anxiety, depression, autism, teeth, joints, seizures, kidneys, and heart. Caregivers also described the challenges of caring for someone with Kabuki syndrome, including an impact on emotional well‐being and the ability to work outside the home. This unique research characterizes the caregiver experience of living with and caring for someone with Kabuki syndrome, both through observed manifestations of Kabuki syndrome in their own children and their experience managing their treatment. Additional research is needed to investigate the patient experience of living with Kabuki syndrome.
Influence of talc fillers on bimodal polyethylene composites for ground heat exchangers
Authors: Kalantar Mehrjerdi Adib , Åkesson Dan , Skrifvars Mikael 
Published: April 2020

AbstractIn this study, a commercial grade of talc is used as filler in a bimodal high‐density polyethylene (HDPE) used for the pressure pipe application. The composites are characterized by thermogravimetric analysis (TGA), differential scanning calorimetry, dynamic mechanical thermal analysis, and tensile testing. The results illustrate that the presence of talc has a considerable effect on the material properties and the pipe life‐length. It is presented that the thermal stability measured by TGA is enhanced, while the oxidation induction time decreases in cooperation of the talc. The nucleation behavior of talc particles during crystallization has no obvious effect on melting temperature; however, an increase in crystallization temperature is evidenced. Storage modulus as recorded from the dynamic mechanical analysis is also increased in all composites, furthermore, the temperature of the α relaxation is shifted toward higher temperature and finally the strain hardening modulus for the HDPE/talc composites is assessed and compared to the neat HDPE as a measure of environmental stress crack resistance.
Cytochrome P450 expression patterns in human osteoblasts during osteogenic differentiation with or without TNFα treatment
Authors: Pathak Janak L. , Liu Lingyu , Zhu Yong‐qiang , Bureik Matthias 
Published: April 2020

AbstractBackgroundRecently the expression patterns of several cytochrome P450 (CYP) genes in different human osteoblast models were reported. However, the various expression patterns of CYPs in human osteoblasts during different stages of osteogenic differentiation have not been investigated and the effect of inflammatory cytokines on CYPs expression in osteoblasts is unknown.MethodsThe expression levels of nine different CYP genes in the human osteoblast cell line MG63 and in primary human osteoblasts (HOB) during osteogenic differentiation with or without treatment with tumor necrosis factor‐α (TNFα) were analyzed by quantitative real‐time PCR.ResultsThe expression levels of most CYPs under study show a significant time dependence during osteogenic differentiation. Overall, more highly significant CYP expression level changes occur in HOB than in MG63 cells. Treatment with TNFα causes a variety of CYP expression level changes in both HOB and MG63 cells.ConclusionsOur findings indicate that TNFα treatment reduces steroid hormone production in MG63 cells (but not in HOB) at the level of lanosterol‐demethylation during cholesterol biosynthesis. By contrast, TNFα treatment of HOB cells (but not in MG63) leads to the upregulation of several key enzymes involved in the biosynthesis of sex steroids, which is proposed to lead to higher levels of estrogen production. These data also suggest that at least with respect to the topic of this study the cell line MG63 is not a good representative for osteoblasts and that it is preferential to use primary osteoblasts instead.
Tailoring translational strength using Kozak sequence variants improves bispecific antibody assembly and reduces product‐related impurities in CHO cells
Authors: Blanco Noelia , Williams Ambrose J. , Tang Danming , Zhan Dejin , Misaghi Shahram , Kelley Robert F. , Simmons Laura C. 
Published: April 2020

AbstractOptimal production of bispecific antibodies (bsAb) requires efficient and tailored co‐expression and assembly of two distinct heavy and two distinct light chains. Here, we describe a novel technology to modulate the translational strength of antibody chains via Kozak sequence variants to produce bsAb in a single cell line. In this study, we designed and screened a large Kozak sequence library to identify 10 independent variants that can modulate protein expression levels from approximately 0.2 to 1.3‐fold compared with the wild‐type sequence in transient transfection. We used a combination of several of these variants, covering a wide range of translational strength, to develop stable single cell Chinese hamster ovary bispecific cell lines and compared the results with those obtained from the wild‐type sequence. A significant increase in bispecific antibody assembly with a concomitant reduction in the level of product‐related impurities was observed. Our findings suggest that for production of bsAb it can be advantageous to modify translational strength for selected protein chains to improve overall yield and product quality. By extension, tuning of translational strength can also be applied to improving the production of a wide variety of heterologous proteins.