bluuebunny/crossref_metadata_2025_split huggingface dataset:
HEALTH AND WELL-BEING AFTER DISPLACEMENT IN LATE LIFE AMONG ASIANS
Authors: Li Wenjun , Glicksman Allen , Balaswamy Shantha 
Published: November 2019

Abstract
Displacement in late life may cause social and health issues. Displaced older adults may experience language and cultural barriers, loss of social networks, difficulties in navigation in new physical and social environments, limited options in transportation and mobility, delayed access to health care, and thus sudden or gradual loss of their autonomy, and increasing dependence on their adult children. These issues are known but not well understood, and effective interventions are yet to do developed. This symposium brings together four studies that address several critical social and health issues among late-life Asian immigrants. Dr. Inoue discusses use of person-centered care to reduce social isolation and loneliness among old and ill Asian immigrants in long term care settings. Ms. Ring examines racial differences in navigation and access to long term aging services and social supports (LTSS), and evaluates the use of Social Interaction Modeling to help connect limited English-speaking minorities in need to the formal LTSS system. Dr. Torres from Sweden provides a systematic review of research into racial/ethnic differences in health and social care, and from an international perspective, advocates a research agenda that is both diversity-astute and injustice-aware. In settings where self-report data are likely unreliable, Dr. Li demonstrates an innovative method for objectively measuring spatiotemporal patterns of physical and social activities and use of neighborhood resources among non-English speaking late-life immigrants. Together these studies demonstrate that existing methods can be adapted and new methods can be created to answer important health and social issues among late-life Asian immigrants.
MEASURING SPACE AND TIME USE, PHYSICAL AND SOCIAL ACTIVITIES AMONG NON-ENGLISH SPEAKING LATE-LIFE ASIAN IMMIGRANTS
Authors: Li Wenjun , Churchill Linda , Cheng Jie , Siden Rachel , Aguirre Annabella , Kane Kevin 
Published: November 2019

Abstract
Little is known about the health and health care needs of non-English Speaking late-life Asian immigrants. Due to language barriers and memory issues, self-report data are unreliable for investigating activity patterns in this population. In the ongoing NIA-funded Healthy Aging and Neighborhood Study, we developed a novel method to objectively measure space and time use, location- and time-specific physical and social activities using accelerometer (ACC) and Global Positioning System (GPS) devices. The study has recruited over 150 Caucasians and 150 minorities including 50 non-English speaking late-life Asian immigrants. The participants answered surveys in their preferred language (English, Spanish, traditional or simplified Chinese) and wore ACC/GPS devices for 7 to 10 full days. Activity levels and geographic locations are recorded every 30 seconds. Using the combined ACC/GPS data, time- and location-specific activity amounts, time use and mobility patterns are objectively measured. Baseline findings will be reported at the GSA conference.
COMMUNITY BELONGING THROUGH THEATER: CREATIVE ARTS INTERVENTION FOR LOW-INCOME OLDER ADULTS
Authors: Dunkle Ruth E , Sutherland Laura , Pace Garrett T , Kennedy Ariel , Baldwin Patricia 
Published: November 2019

Abstract
Creative arts can promote social contact and possibly reduce isolation. A professionally run theater group comprised of low-income older adults met for 12 weeks to learn basic skills and perform a play. Using a pre-post questionnaire, data were gathered from the treatment group (n=14) who participated in the class and a non-participating comparison group (n=5) to identify potential program effects on measures of social isolation, community belonging, and social exclusion. Participants were African American living in low-income housing in an urban area. The average age of the sample was 65 years, 21% were men, 83% had at least high school degree, 71% reported good to excellent health, and 58% reported at least one ADL. Regression analyses showed that a sense of community belonging was significantly greater for the treatment group than the comparison group at time 2.This was not the case when considering social isolation or social exclusion. When controls were added (age, health, and previous theater experience), the significant difference remained with higher age predicting a sense of community belonging. The greater number of class sessions attended was also associated with a greater sense of community belonging for the treatment group. Through the shared experience of theater, participants can gain a sense of community, but this activity does not seem to be related to social isolation or social exclusion. It could be that theater participation fosters a sense of belonging due to group dynamics but is not a significant enough activity to reduce a sense of isolation or exclusion.
PHYSICAL ACTIVITY INTERVENTION IN HOME CARE: COMPARING FAMILY AND NON-FAMILY CAREGIVING DYADS
Authors: Muramatsu Naoko , Yin Lijuan 
Published: November 2019

Abstract
An increasing number of states pay family members who care for older adults in Medicaid-funded home care. Previous research documented pros and cons of hiring family members as home care providers. However, little is known about whether family and non-family caregiving dyads function differently when they participate in health promotion interventions in home care. Using data collected in a pilot study of a gentle physical activity program delivered by home care workers in a Medicare home care program, this study compared 18 family and 32 non-family caregiving dyads in client outcomes (self-reported and performance-based function) and process outcomes (exercise-related social support provided by home care aides) before and after the intervention. Linear mixed models indicated that client outcomes improved after the 4-month intervention (p&lt;0.05), controlling for clients’ age, gender, and number of chronic conditions. Compared to family caregiving dyads, greater improvement in exercise-related support was observed in non-family caregiving dyads (p&lt;0.05), where care providers offered less exercise-related support at baseline. The intervention program was received well by both family and non-family dyads, as expressed by one of the caregivers: “It makes my client feel good about herself. I also feel good for my client.” Results suggest that empowering caregivers with health promotion skills is a promising strategy, especially in non-family caregiving dyads. Further research is warranted to produce evidence-based health promotion programs for family and non-family caregiving dyads in home care.
COGNITIVE DECLINE AMONG OLDER ADULTS IN RURAL CHINA: THE PROTECTIVE ROLE OF FORMAL SCHOOLING
Authors: Pei Yaolin , Wu Bei , Cong Zhen , Hu Mengyao 
Published: November 2019

Abstract
Evidence shows that education is strongly associated with cognitive functioning; however, few studies have examined the effect of education on cognitive decline among older adults with very limited education. Our study analyzed six waves of panel data (2001, 2003 2006, 2009, 2012 and 2015) from the Longitudinal Study of Older Adults in Anhui Province, China. We estimated two-level multilevel models of cognitive functioning for older adults age 60+, sampled using probability sampling strategy. We found that having formal schooling was positively associated with better cognitive functioning. Older adults with formal schooling had slower decline in cognition and the gap in cognition between the literate and illiterate widened with age. These findings highlight the role of early life experience in affecting cognitive function in later life and suggest that disadvantages in cognitive functioning accumulate throughout the life course for persons with no formal education.
SYSTEMS LEVEL UNDERSTANDING OF AGING
Authors: Labunskyy Vyacheslav 
Published: November 2019

Abstract
Aging is a complex trait is controlled by multiple genetic and environmental factors. Genome-wide screens in invertebrate organisms have led to the identification of hundreds of genes, whose deletion or knockdown can dramatically increase lifespan. Many of these genes represent conserved signaling pathways and biological processes suggesting that they might be involved in the regulation of mammalian aging. Nevertheless, the mechanistic basis by which the majority of these long-lived gene deletions extend lifespan remains poorly understood. Using yeast Saccharomyces cerevisiae as a model system, we employ systems biology network analysis of transcriptomic and protein expression data to build a detailed translational regulatory network of aging in yeast and identify genetic interactions among various aging pathways. Through these studies we expect to gain understanding how the regulatory networks are perturbed with aging, which could provide important insights into human disorders associated with the old age.
WADDINGTON’S LANDSCAPE OF CELL AGING
Authors: Hao Nan , Li Yang , Jiang Yanfei , Paxman Julie , O’Laughlin Richard , Pillus Lorraine , Tsimring Lev , Hasty Jeff 
Published: November 2019

Abstract
Cellular aging is a complex process that involves many interwoven molecular processes. Studies in model organisms have identified many individual genes and factors that have profound effects on lifespan. However, how these genes and factors interact and function collectively to drive the aging process remains unclear. We investigated single-cell aging dynamics throughout the replicative lifespans of S. cerevisiae, and found that isogenic cells diverge towards two aging paths, with distinct phenotypic changes and death forms. We further identified specific molecular pathways driving each aging fate and revealed that these pathways interact and operate dynamically to enable an early-life switch that governs the aging fate decision and the progression towards death. Our work uncovers the interconnected molecular pathways that drives the aging process and opens up the possibility of designing interventions that simultaneously target multiple network nodes, instead of single genes, to more effectively extend the healthspan.
GENOME-WIDE ASSOCIATION STUDY OF EXTREME HUMAN LONGEVITY DISCOVERS UNCOMMON LONGEVITY VARIANTS
Authors: Gurinovich Anastasia , Gurinovich Anastasia , Song Zeyuan , Andersen Stacy L , Perls Thomas T , Sebastiani Paola 
Published: November 2019

Abstract
The strong heritability of extreme human longevity supports the hypothesis that this is a genetically-regulated trait. However, association studies focused on common genetic variants have discovered a limited number of longevity-associated genes. We conducted a genome-wide association study of 4,216 individuals including 1317 centenarians from the New England Centenarian Study (median age = 104 years) using &gt;9M genetic variants imputed to the HRC panel of ~65,000 haplotypes. The set included approximately 5M uncommon variants. The associations were tested using a mixed effect logistic regression model with genotype-based kinship covariance of the random effects to adjust for cryptic relations using the package GENESIS. The analysis discovered 45 genome-wide significant SNPs (p&lt; 5E-08) including 8 new loci in chromosomes 3, 6, 7, 9, 10, 14 and 15 in addition to the APOE locus. The list includes new pQTLs in serum that suggest a new biological mechanism involved in extreme human longevity.
MULTI-OMIC BIOLOGICAL AGE ESTIMATION, CORRELATION WITH WELLNESS, DISEASE PHENOTYPES: LONGITUDINAL SAMPLE OF 3558
Authors: Price Nathan , Price Nathan , Earls John , Rappaport Noa , Heath Laura , Wilmanski Tomasz , Lovejoy Jennifer , Hood Leroy 
Published: November 2019

Abstract
Biological age (BA) has been shown to be a better predictor of mortality and disease than chronological age (CA). Aging’s diverse effects are visible across many data types. We investigated BA from deep phenotyping of 3558 wellness program participants and controls. The Klemera-Doubal BA estimation algorithm was applied to genetic and longitudinal clinical laboratory, metabolomic, and proteomic assay data. BA trajectories were calculated using Generalized Estimating Equations. BA of individuals with Type-2 Diabetes averaged 6+ years greater than CA. Wellness program participation decreased individuals’ rate of aging (coefficient: -0.16, 95% CI: -0.45, 0.19), with effects dependent on sex, initial BA, and CA. Measures of metabolic health, inflammation, and toxin bioaccumulation were strong predictors across data types and sex. Deep phenotyping enabled calculation of a BA measure and a wellness program improved BA, either in absolute terms or relative to CA, showing it is modifiable.
UNDERSTANDING AND ADDRESSING IMMUNOSENESCENCE
Authors: Van Der Most Robbert 
Published: November 2019

Abstract
Aging comes with an increased impact of infectious disease in terms of hospitalization, morbidity and mortality. This increased susceptibility to infection appears to be linked to age-related changes in the immune system and its capacity to respond to infection and vaccination. Importantly, this phenomenon occurs despite existence of pre-existing immune memory. The age-related weakening of the immune response is referred to as “immunosenescence”. Immunosenescence operates at several levels of the immune system and is multifactorial. Recent advances in systems immunology have shed new light on the immunological processes that may drive the age-related changes in immune response to infection and vaccination. However, gaps in our understanding still exist at basic and translational research levels. One approach to counteract this is the development and implementation of innovative vaccines against the pathogens with particular risks for older adults. The use of innovative immune adjuvants holds promise for the development of such vaccines.
IMPLICATIONS OF RELATIONSHIPS WITH FAMILY, FRIENDS, AND NEIGHBORS FOR WOMEN'S WELL-BEING IN LATE LIFE
Authors: Fuller Heather , Fuller Heather , Toyama Masahiro 
Published: November 2019

Abstract
Social support is well documented as promoting women’s well-being across the lifespan, yet implications vary depending on the source and type of support. The present study examined whether relationships with family, friends, and neighbors (both satisfaction with and number in social network) affected well-being over two years. Midwestern women (N=188, mean age = 80) were sampled from two waves of the Social Integration and Aging Study (2013, 2015). Hierarchical regression models indicated that satisfaction with friends predicted better life satisfaction, but satisfaction with family and neighbors did not predict well-being. In contrast, number of neighbors in social network predicted lower life satisfaction and greater stress, while number of family and friends were not associated with well-being. Moreover, differential effects emerged between older and younger women. Findings highlight unique facets of older women’s social relationships and suggest that future research and interventions addressing age and the source of support are warranted.
THE HEALTH OF MALE VETERANS IN LATER LIFE
Authors: Wilmoth Janet M , Landes Scott D , London Andrew S 
Published: November 2019

Abstract
Veterans have the opportunity to accrue health-promoting “military capital,” but they are also at risk of experiencing a “military hazard” effect that undermines later-life health and mortality outcomes. Given these possibly competing effects, there is substantial heterogeneity in physical and mental health among older male veterans. The health and mortality outcomes of older veterans who were not substantially harmed during military service appear to be just as good as, if not better than, those of nonveterans. However, older veterans who served in-theater, were exposed to combat or hazardous chemicals, and/or were physically or psychologically harmed during service tend to have worse health and higher mortality than non¬veterans. Some older veterans with these experiences struggle with life-long or late-onset PTSD, while others exhibit resilience and posttraumatic growth. Additional population-level, life-course research is needed on specific war-era cohorts to identify the mechanisms that shape veteran status differences in late-life health and mortality.
FACTORS INFLUENCING SELF-REPORTED COGNITION OVER TIME
Authors: Hill Nikki , Katz Mindy 
Published: November 2019

Abstract
Self-reported cognitive problems among cognitively intact older adults are often associated with an increased risk of future cognitive decline and Alzheimer’s disease (AD). However, cross-sectional evidence suggests that self-reported cognition may be more influenced by factors such as personality or affective symptoms than concurrent objective cognitive performance. Furthermore, self-reported cognition is measured using a variety of items that assess different constructs (e.g., current memory performance, perceived decline over time), which may be differentially influenced by individual characteristics or item interpretation. The purpose of this symposium is to present findings from multiple analyses that examined the influence of individual characteristics (i.e., personality, perceived stress, and family history of dementia) on self-reported cognitive problems, and to further describe how item type influences older adults’ responses to questions about their memory. First, we present the results of an investigation that examined the influence of personality on three types self-reported memory, with a specific focus on how these associations may differ in Black and White older adults. Second, we extend this discussion with results of an examination of associations among personality, family history of AD, and memory self-report. Our third presentation explores bidirectional associations between perceived stress and memory complaints over time. And finally, we present the results of a factor analysis of self-reported cognition items that distinguishes those that tend to travel together over time from those that are better at discriminating between individuals.
POTENTIAL BENEFITS FROM LIVING IN A CCRC
Authors: Wyatt-Brown Anne 
Published: November 2019

Abstract
Unlike many people who hope to postpone moving until late in life, my husband and I had to move quickly because he could no longer manage the stairs in our condo. We chose a nearby CCRC where my parents had lived in the 1980s. My husband loved our choice, and gradually I adjusted to life in an institution. When he died in 2012, I had to start over again as a single woman. Fortunately, people were very kind to me, which made adjusting much easier. Other residents were equally supportive when I had breast cancer, which involved chemo and radiation. I realized recently that co-residents have taught me to make supportive comments when people tell me that they can’t remember names. Acknowledging that we all have declines to deal with makes it easier for us all to accept aging’s inevitable changes while using our housing community for support.
DO WHAT I SAY, NOT WHAT I DO? CHALLENGING CONTEMPORARY WISDOM ABOUT RESIDENCE IN OLD AGE
Authors: Rowles Graham D 
Published: November 2019

Abstract
An environmental gerontologist teaching about “aging and environment” for 30 years, I had it all figured out. Downsize and divest, stair free environment, universal design, environmental centralization, location close to services. At 60, I was consulting with an architect to design an age friendly home and searching for a level plot. But then, serendipitously, we found our current home, a residence defying all of these principles. An irresponsible denial of aging and pending frailty? Thirteen years later, I’m not so sure. In this presentation, I explain why, focusing on processes of “making and remaking home” and “being in place” that have been central themes in my research career. I explore ways in which as my wife and I grow older, harnessing modern technologies, newly emergent living arrangements and contemporary communication, we anticipate being able to age in place far longer than has been possible for previous generations.
LEVERAGING COMMUNITIES AS NETWORKS TO REDUCE MALNUTRITION IN OLDER ADULTS
Authors: Sadarangani Tina , Beasley Jeannette , Jarrott Shannon E 
Published: November 2019

Abstract
Malnutrition in older adults, while ubiquitous, remains largely underrecognized and undertreated. In community-dwelling older adults, 25% of those at risk of over or under nutrition do not receive any dietary interventions; routine screenings for malnutrition are not typically required in community-based settings. In this interdisciplinary symposium, we explore issues focused on the delivery of evidence-based nutrition interventions to meet the needs of community-dwelling older adults. Using national survey data, we begin by underscoring the importance of treating the complex needs of adults at risk of malnutrition by examining health sequelae, specifically hospitalizations, in community-dwelling adults receiving home-delivered meals. We subsequently examine approaches to malnutrition screening in community-based settings, focusing on the utility of the DETERMINE checklist. We explore barriers and facilitators of providing person-centered nutrition to ethnically diverse Asian American older adults in the adult day healthcare setting. Finally, we shift our focus to overnutrition, discussing the dissemination of a telehealth diabetes prevention program, BRInging the Diabetes prevention program to GEriatric populations (BRIDGE) among older adult meal program recipients. Older adults in community-based health settings are at risk of malnutrition, and among them, those who are prone to social isolation, are at highest risk for adverse outcomes. While congregate settings can facilitate social interaction, honoring food preferences and facilitating choice to address undernutrition, is challenging. Conversely, telehealth interventions may present a feasible approach for addressing overnutrition. We conclude by discussing how current and future research can inform innovative person-centered community-based approaches to identify and treat malnutrition.
EXPLORING HOW CARE PROVIDERS TALK ABOUT COMMUNICATION DIFFICULTIES WITH ETHNIC MINORITY PATIENTS
Authors: Ågård Pernilla 
Published: November 2019

Abstract
Previous research into cross-cultural interactions in health care settings shows that care providers experience communicating with elderly ethnic minority patients as problematic. According to the social constructionist framework upon which this presentation draws, people negotiate the characteristics they ascribe to the world around them through talk. It is against this backdrop that the presentation – which is based on a focus group study with end-of-life care providers (n=60) – sets out to explore how care providers talk about communication difficulties with elderly ethnic minority patients. The presentation demonstrates how the study of communication difficulties can illustrative the challenges of cross-cultural interaction in end-of-life care settings. Through the attention on how communication difficulties are discussed, this presentation shifts the focus from the elderly ethnic minority patients and the reasons for why they are experienced as problematic when it comes to communication, to the actual process where these problems are negotiated.