bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding underactive bladder: a review of the contemporary literature
Authors: Santos-Pereira Mariana , Charrua Ana 
Published: July 2020

AbstractUnderactive bladder (UAB) is characterized by prolonged voiding, hesitancy, and slow and/or intermittent stream with or without a sensation of incomplete bladder emptying. The overlap of UAB lower urinary tract symptoms with those of overactive bladder or bladder outlet obstruction, as well as its multifactorial etiology, make UAB study, as well as its diagnosis and management, a very arduous and challenging task. Therefore, despite its incidence and significant impact in the quality of life of both men and women, UAB remains a poorly understood urologic condition with insufficient and ineffective treatment options available. In this review, we will focus on the etiology theories that have been proposed and the animal models available to test those theories.
Effects of different dosages of Sodium-Glucose Transporter 2 Inhibitors on lipid levels in patients with type 2 diabetes mellitus
Authors: Cai Tingyu , Gao Yang , Zhang Li , Yang Ting , Chen Qiu 
Published: July 2020

Abstract

Background:
Type 2 diabetes mellitus is one of the most common chronic diseases, which endangers peoples health and life qualities. Sodium-Glucose Transporter 2 (SGLT2) inhibitors have been widely recognized since their clinical application in blood glucose control. While, dyslipidemia caused by SGLT2 inhibitors has been identified that affected the prognosis of this disease.

Methods:
We will retrieve 8 databases including English and Chinese. After multiple screening, all randomized controlled trials (RCTs) related to SGLT2 inhibitors will be included by the 2 authors and data will be extracted. After completion of the risk of bias assessment, we will use these effect values including risk ratio (RR), weighted mean difference (WMD) and 95% confidence interval (CI) to conduct data analysis. Chi-Squared test and I
2 test will be used to assess heterogeneity between studies. The robustness of meta-analysis results will be determined by sensitivity analysis. It will be assessed that evidence quality of the outcomes on the GRADE.

Results:
The results of our research will be published in a peer-reviewed journal.

Conclusion:
The purpose of this systematic review and meta-analysis is to evaluate the association and degree of association between different doses of SGLT2 inhibitors and changes on blood lipid levels in patients with type 2 diabetes mellitus, in order to provide a reliable basis for clinical medication.

INPLASY registration number:
INPLASY202040201.
Methodology of dose calculation for external beam radiation combined with high dose rate brachytherapy in the era of 3-dimensional treatment planning system
Authors: Wang Fangzheng , Jiang Chuner , Liu Tongxin , Sun Quanquan , Ye Zhimin , Shi Kaiyuan , Wu Peng , Qin Weifeng , Fu Zhenfu , Jiang Yangming 
Published: July 2020

Abstract
Intracavitary application of brachytherapy (BT) sources followed by external beam radiation is essential for the local treatment of carcinoma of the cervix, postate, and nasopharynx. Dose distribution of external beam radiation plus BT can be challenging for the planning system because of their dose calculation by 2 different treatment planning system (TPS). The aims of this study were to introduce a novel iterative method of dose calculation preformed in the Pinnacle plan and evaluate a combined dose distribution for external beam radiation and BT.
Because it is often the goal of the planner to produce plan with uniform dose throughout the target volume and normal tissue, we present an Iridium-192 calculation program using American Association of Physicists in Medicine Task Group 43 formula and export it to other commercialized TPS though the combined dose distribution of external beam radiation and BT can be shown. To illustrate such an improved procedure, we present the treatment plans of 2 patients treated with external beam radiation plus BT.
Dose distribution of the single BT source were calculated with the Plato post loading TPS and the program model, and the results of 2 methods were similar. A nasopharyngeal case and a cervical case were shown in Pinnacle with this program. The total dose distribution of BT combined with EBRT was showed in compute tomography images. And the corresponding dose volume histogram figures could be displayed correctly in Pinnacle TPS.
We demonstrated a novel iterative method of dose calculation preformed in the Pinnacle plan to produce a combined dose distribution for external beam radiation and BT. We used it to evaluate the dose of target volume and normal tissues in the treatment of external beam radiation plus BT.
Synchronous primary pulmonary adenocarcinoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue
Authors: Sun Lixia , Zhang Bing , Xuan Ke , Qi Li , Wang Jingjing , Li Quan , Liu Jianwei , Wang Yubo , Sun Liping , Li Xiaomei , Ji Hong 
Published: July 2020

Abstract

Rationale:
Synchronous pulmonary lymphoma and carcinoma is relatively rare. And synchronous pulmonary lymphoma and adenocarcinoma in the same site is extremely rare.

Patient concerns:
We presented a 69-year-old female with a tumor mass in right upper lung.

Diagnosis:
Pathological and immunohistochemical findings revealed lung adenocarcinoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue.

Interventions:
The patient received thoracoscopic guided right upper lobectomy and focal lymph node dissection after systemic anesthesia. Besides, 6 cycles of chemotherapy were given based on meprednisone, gemcitabine and cisplatin in local hospital.

Outcomes:
In the 12-month follow-up, the patient was still alive with no local recurrence, metastasis and lymph node involvement.

Lesson:
A comprehensive literature research was performed, and 6 cases of synchronous pulmonary lymphoma and adenocarcinoma in the same site and 10 cases in different sites were identified since 2000. Most patients with synchronous pulmonary lymphoma and carcinoma were middle-aged and elderly with the median age was 64 years presenting a male predisposition. The most frequent type of primary pulmonary lymphoma was B-cell non Hodgkin lymphoma, especially mucosa-associated lymphoid tissue lymphoma, and the lung cancer is predominantly adenocarcinoma.
Kawasaki disease shock syndrome complicated with bilateral lung consolidation in a child
Authors: Song Yue , Wei Wuran , Liu Lan , Wang Yibing , Shi Xiaoqing , Li Li 
Published: July 2020

Abstract

Introduction:
Kawasaki disease (KD) is a systemic inflammatory disease. Standard imaging features of KD include interstitial and lobular inflammatory lesions in the lungs, while KD shock syndrome (KDSS), complicated with substantial consolidation and atelectasis in the lung, is rarely reported.

Patients concerns:
Herein, we report a single case of a 5-year-old female patient who manifested KDSS on the seventh day of the course of KD. Chest enhanced computed tomography indicated large-area consolidation in the lower lobes of the bilateral lungs.

Diagnosis:
The patient was diagnosed with KDSS complicated with non-infective lung consolidation.

Interventions:
The patient received human intravenous immunoglobulin (2 g/kg) and aspirin (30–50 mg/kg.d), methylprednisolone, a vasoactive agent, and albumin. Infective factors were excluded.

Outcomes:
The consolidation in the lower lobe of the bilateral lungs was completely recovered after 3 days of treatment.

Conclusions:
Children with KDSS may present with pulmonary lesions such as substantial consolidation and atelectasis; thus, infective factors should be excluded. If there is no etiological evidence, antibiotics should be used with caution.
Extralobar pulmonary sequestration with a complication of torsion
Authors: Yang Lei , Yang Gang 
Published: July 2020

Abstract

Rationale:
Pulmonary sequestration is a congenital abnormality of the lower airway. It is characterized by a nonfunctioning mass of lung tissue that lacks normal communication with the tracheobronchial tree or pulmonary arteries and always receives its arterial blood supply from the systemic circulation. Most cases of extralobar pulmonary sequestrations (ELSs) are asymptomatic and found incidentally or in prenatal ultrasound screening.

Patient concerns:
A 10-year-old boy had severe chest pain and vomiting for 2 days.

Diagnoses:
ELS was diagnosed, and torsion of the ELS had developed as a complication.

Interventions:
In video-assisted thoracoscopic surgery, the ELS was resected.

Outcomes:
The clinical symptoms were relieved the 2nd day after surgery and did not recur over a follow-up period of 3 months.

Lessons:
In young patients with sudden abdominal pain or chest pain, in whom computed tomography shows a well-defined mass of homogeneous soft-tissue density in the thorax, ELS with torsion should be suspected. The presence of a feeding artery greatly supports the diagnosis of ELS, and the absence of this classic finding may indicate torsion of the pulmonary sequestration.
Spindle cell lipoma of the larynx
Authors: Qin-ying Wang , Shui-hong Zhou , Yong-cai Liu , Hai-hong Chen 
Published: July 2020

Abstract

Introduction:
Lipomas are rarely found in primary mesenchymal tumors of the hypopharynx and larynx. When they do appear, they often macroscopically resemble a retention cyst or laryngeal nodule. The laryngeal spindle cell lipoma, a variant, is extremely rare.

Patient concerns:
A 65-year-old woman presented with a 3-month history of pharyngeal paraesthesia. Laryngoscopy revealed the presence of a well-encapsulated, smooth-surfaced, yellowish, pedicled mass on the left epiglottis. Magnetic resonance imaging confirmed the epiglottic mass.

Diagnosis:
Following excision of the mass, the diagnosis of an spindle cell lipoma was established and confirmed by immunohistochemistry.

Interventions:
Surgical excision of the lesion using a controlled-temperature plasma technique (coblation).

Outcomes:
At the last (4-year) follow-up evaluation, the patient was asymptomatic and without recurrence.

Conclusion:
SLC involvement of the epiglottis is rare. Coblation is an effective means to remove it.
Facial emotion recognition in adult with traumatic brain injury
Authors: Lin XiaoGuang , Zhang XueLing , Liu QinQin , Zhao PanWen , Zhang Hui , Wang HongSheng , Yi ZhongQuan 
Published: July 2020

Abstract

Background:
Traumatic brain injury (TBI) refers to head injuries that disrupt normal function of the brain. TBI commonly lead to a wide range of potential psychosocial functional deficits. Although psychosocial function after TBI is influenced by many factors, more and more evidence shows that social cognitive skills are critical contributors. Facial emotion recognition, one of the higher-level skills of social cognition, is the ability to perceive and recognize emotional states of others based on their facial expressions. Numerous studies have assessed facial emotion recognition performance in adult patients with TBI. However, there have been inconsistent findings. The aim of this study is to conduct a meta-analysis to characterize facial emotion recognition in adult patients with TBI.

Methods:
A systematic literature search will be performed for eligible studies published up to March 19, 2020 in three international databases (PubMed, Web of Science and Embase). The work such as article retrieval, screening, quality evaluation, data collection will be conducted by two independent researchers. Meta-analysis will be conducted using Stata 15.0 software.

Results:
This meta-analysis will provide a high-quality synthesis from existing evidence for facial emotion recognition in adult patients with TBI, and analyze the facial emotion recognition performance in different aspects (i.e., recognition of negative emotions or positive emotions or any specific basic emotion).

Conclusions:
This meta-analysis will provide evidence of facial emotion recognition performance in adult patients with TBI.

INPLASY registration number:
INPLASY202050109.
Effects of concurrent aerobic and resistance exercise in frail and pre-frail older adults
Authors: Meng Nai-Hsin , Li Chia-Ing , Liu Chiu-Shong , Lin Chih-Hsueh , Chang Chin-Kai , Chang Heng-Wei , Yang Chuan-Wei , Li Tsai-Chung , Lin Cheng-Chieh 
Published: July 2020

Abstract

Background:
This study aimed to investigate the effects of supervised and home-based exercise programs on older people with frailty or pre-frailty.

Methods:
A total of 146 community-dwelling participants aged 65 and older who were prefrail or frail were randomly allocated into supervised exercise (N = 74) and home exercise (N = 72) groups. The 3-month supervised exercise training consisted of 3 exercise sessions per week, was performed at a hospital and supervised by a physical therapist. Home exercise participants took instructions on exercise and illustrated exercise handouts. The baseline and 3-month follow-up measurements included body composition, strength of selected upper and lower limb muscle groups, grip and leg press strengths, and five physical performance tests. Mixed-model repeated-measures analysis was applied to determine whether two groups differ in terms of changes before and after the intervention and to compare within-group improvements.

Results:
After 3 months of supervised or home-based exercise, the average number of frailty criteria met and fat percentage decreased significantly. Strength of knee extensors, knee flexors and leg press improved significantly in supervised exercise group. In home-based exercise group, the strength of all muscle groups tested improved significantly, except for leg press strength. Walking speed improved in both groups, and timed-up-and-go and timed chair rise tests improved significantly only in supervised exercise group.

Conclusions:
Three-month supervised or home-based exercise improved walking speed and strength of the limb muscles. Supervised group showed more improvements in the physical performance tests compared with home-based exercise group.
Designing an optimal inventory management model for the blood supply chain
Authors: Ahmadimanesh Monireh , Tavakoli Ahmad , Pooya Alireza , Dehghanian Farzad 
Published: July 2020

Abstract
Blood supply managers in the blood supply chain have always sought to create enough reserves to increase access to different blood products and reduce the mortality rate resulting from expired blood. Managers’ adequate and timely response to their customers is considered vital due to blood perishability, uncertainty of blood demand, and the direct relationship between the availability/lack of blood supply and human life. Further to this, hospitals’ awareness of the optimal amount of requests from suppliers is vital to reducing blood return and blood loss, since the loss of blood products surely leads to high expenses. This paper aims to design an optimal management model of blood transfusion network by a synthesis of reusable simulation technique (applicable to all bases) and deep neural network (the latest neural network technique) with multiple recursive layers in the blood supply chain so that the costs of blood waste, return, and shortage can be reduced. The model was implemented on and developed for the blood transfusion network of Khorasan Razavi, which has 6 main bases active from October 2015 to October 2017. In order to validate the data, the data results of the variables examined with the real data were compared with those of the simulation, and the insignificant difference between them was investigated by t test. The solution of the model facilitated a better prediction of the amount of hospital demand, the optimal amount of safety reserves in the bases, the optimal number of hospital orders, and the optimal amount of hospital delivery. This prediction helps significantly reduce the return of blood units to bases, increase availability of inventories, and reduce costs.
Efficacy and safety of epidural steroid injection following discectomy for patients with lumbar disc herniation
Authors: Cai Jianping , Jiang Wei , Qiu Beiming , Song Yuguang 
Published: July 2020

AbstractBackground:Concerns exist regarding the analgesia effect and safety of epidural steroid injection (ESI) after discectomy. There is an urgent need of studies that efficiently control for confounding, conduct comprehensive and consecutive observation of potential risks of ESI, and investigate its clinical applicability. We thus further designed a randomized controlled study to assess the efficacy of ESI on postoperative pain and complications in patients undergoing unilateral lumbar microdiscectomy.Methods:This prospective, blinded randomized controlled trial was conducted at our single hospital. This study was approved by the Committee at the No.2 People's Hospital of Yibin. All procedures were performed by a single surgeon and informed consent was obtained from each patient. Ninty eligible patients diagnosed at our institution with herniated lumbar disc during a period from June 2020 to July 2021 will be assessed. Group 1 was a mixture of 1 mL of 0.5% bupivacaine and 10 mg of triamcinolone acetonide in 1 mL. Group 2 was a mixture of 1 mL of 0.5% bupivacaine and 1 mL of normal saline. The primary outcome measure was the amount of morphine consumption from a patient-controlled analgesia pump at 12, 24, and 48 hours after surgery. The following secondary outcomes were also assessed: postoperative pain score, back pain score, functional disability, and adverse effect.Conclusions:We hypothesized that the ESI was associated with lower pain score, morphine consumption, and hospital stay, with no significant difference in complications for ESI application after lumbar discectomy in lumbar disc herniation when compared with placebo.Trial registration:This study protocol was registered in Research Registry (researchregistry5683).
A protocol of systematic review and meta-analysis of narrow band imaging endoscopy in detection of early gastric cancer
Authors: Liu Xiao-yu , Zhang Jun 
Published: July 2020

Abstract

Background:
Although previous studies have utilized narrow band imaging endoscopy diagnosis (NBIED) in detection of patients with early gastric cancer (EGC), there are still inconsistent results. Thus, this study will explore the accuracy of NBIED in detection of patients with EGC.

Methods:
We propose to perform literature search of potential studies investigating the accuracy of NBIED in detection of patients with EGC in MEDLINE, EMBASE, Cochrane Library, Web of Science, WANGFANG, VIP database and China National Knowledge Infrastructure from the beginning of each database to January 31, 2020 without restrictions to language and publication time. Two authors will independently scrutinize these databases to identify studies that satisfy all predefined eligibility criteria. We will check study quality and analyze outcome data using Quality Assessment of Diagnostic Accuracy Studies tool, and RevMan 5.3 software respectively.

Results:
We anticipate the results of this study will afford additional insight into the appraising of the accuracy of NBIED in patients with EGC.

Conclusion:
The findings of this study will be useful informing diagnostic decisions for the diagnosis of patients with EGC.
PROSPERO registration number: PROSPERO CRD42020171053.
Factors associated with clearance of hepatitis B virus surface antigen in patients infected with human immunodeficiency virus
Authors: Tsutsumi Takeya , Sato Hidenori , Kikuchi Tadashi , Ikeuchi Kazuhiko , Lim Lay Ahyoung , Adachi Eisuke , Koga Michiko , Okushin Kazuya , Kawahara Takuya , Koibuchi Tomohiko , Yotsuyanagi Hiroshi 
Published: July 2020

Abstract
Owing to similar routes of transmission, hepatitis B virus (HBV) and human immunodeficiency virus (HIV) coinfection commonly occurs. Compared with patients infected with only HBV, coinfected patients develop persistent HBV infection followed by advanced liver diseases. However, the characteristics of HIV-infected patients who can achieve the clearance of HBV surface antigen (HBsAg) have not been clarified. In this study, we retrospectively examined patients coinfected with HBV and HIV and determined the host factors associated with HBsAg clearance.
Among HIV-infected patients who visited our hospital between 1994 and 2017, we examined medical records of those who were seropositive for HBsAg at least once. Among them, patients who cleared HBsAg afterward were regarded as “cured,” while those who remained HBsAg-seropositive until 2017 were “chronic.”
HBsAg seropositivity was found in 57 patients, and among them, 27 male patients were cured whereas 18 were chronic. The cured patients were significantly younger and had higher CD4 cell and platelet counts than the chronic patients. In addition, the cured patients had higher levels of transaminases after the detection of HBsAg. Multivariate analysis revealed age as an independent factor. Analyses of the patients infected with genotype A also showed that the cured patients had significantly higher CD4 cell counts.
Considering that the CD4 cell and platelet counts were higher in the cured patients, immunological and liver functions were closely associated with HBsAg clearance. Higher levels of transaminases in the cured patients may also reflect the immunological function leading to HBsAg clearance.
Infective endocarditis mimicking ANCA-associated vasculitis: does it require immunosuppressive therapy?
Authors: Shi Xiao-dong , Li Wan-yu , Shao Xue , Qu Li-mei , Jiang Zhen-yu 
Published: July 2020

Abstract

Rationale:
In the course of endocarditis, the development of antineutrophil cytoplasmic antibody (ANCA)-mediated disease introduces the dilemma of determining the best treatment approach for immune conditions, whether immunosuppressant therapy should be added to antibiotic treatment has remained controversial.

Patient concerns:
A 33-year-old man presented with progressive fever lasting for 7 months, and swelling, pain, and purpura in the arms and legs. The patient showed multiple autoantibodies including cytoplasmic ANCA, antiproteinase 3, rheumatoid factor, and anti-beta 2 glycoprotein I. Blood culture was positive for viridans streptococcus, and renal biopsy revealed glomerulonephritis and interstitial nephritis.

Diagnosis:
Endocarditis caused by viridans streptococci, ANCA-associated vasculitis, and congenital ventricular septal defect.

Interventions:
In addition to effective antibiotics, he also received twice intravenous corticosteroids and intravenous immunoglobulin therapy, and a low dose of cyclophosphamide. At last, the patient received congenital ventricular septal defect repair and debridement.

Outcomes:
The abnormal clinical manifestations, including renal failure and loss of strength, recovered rapidly with corticosteroid therapy in addition to antibiotic treatment. After 6 months without any medications, he remained asymptomatic and was able to live normally.

Lessons:
In this case with endocarditis and ANCA-associated vasculitis, we highlighted the importance of biopsy and immunosuppressive therapy. Histopathologic examination is required for diagnosis and treatment in such case. Identifying patients who have endocarditis and ANCA positivity with vasculitis pathologic features will require corticosteroid/immunosuppressives in addition to the antibiotics therapy.