bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boron isotope record of peak metamorphic ultrahigh-pressure and retrograde fluid–rock interaction in white mica (Lago di Cignana, Western Alps)
Authors: Halama Ralf , Konrad-Schmolke Matthias , De Hoog Jan C. M. 
Published: February 2020

AbstractThis study presents boron (B) concentration and isotope data for white mica from (ultra)high-pressure (UHP), subduction-related metamorphic rocks from Lago di Cignana (Western Alps, Italy). These rocks are of specific geological interest, because they comprise the most deeply subducted rocks of oceanic origin worldwide. Boron geochemistry can track fluid–rock interaction during their metamorphic evolution and provide important insights into mass transfer processes in subduction zones. The highest B contents (up to 345 μg/g B) occur in peak metamorphic phengite from a garnet–phengite quartzite. The B isotopic composition is variable (δ11B = − 10.3 to − 3.6%) and correlates positively with B concentrations. Based on similar textures and major element mica composition, neither textural differences, prograde growth zoning, diffusion nor a retrograde overprint can explain this correlation. Modelling shows that B devolatilization during metamorphism can explain the general trend, but fails to account for the wide compositional and isotopic variability in a single, well-equilibrated sample. We, therefore, argue that this trend represents fluid–rock interaction during peak metamorphic conditions. This interpretation is supported by fluid–rock interaction modelling of boron leaching and boron addition that can successfully reproduce the observed spread in δ11B and [B]. Taking into account the local availability of serpentinites as potential source rocks of the fluids, the temperatures reached during peak metamorphism that allow for serpentine dehydration, and the high positive δ11B values (δ11B = 20 ± 5) modelled for the fluids, an influx of serpentinite-derived fluid appears likely. Paragonite in lawsonite pseudomorphs in an eclogite and phengite from a retrogressed metabasite have B contents between 12 and 68 μg/g and δ11B values that cluster around 0% (δ11B = − 5.0 to + 3.5). White mica in both samples is related to distinct stages of retrograde metamorphism during exhumation of the rocks. The variable B geochemistry can be successfully modelled as fluid–rock interaction with low-to-moderate (< 3) fluid/rock ratios, where mica equilibrates with a fluid into which B preferentially partitions, causing leaching of B from the rock. The metamorphic rocks from Lago di Cignana show variable retention of B in white mica during subduction-related metamorphism and exhumation. The variability in the B geochemical signature in white mica is significant and enhances our understanding of metamorphic processes and their role in element transfer in subduction zones.
An evaluation of predictors for success of two-duct ligation for drooling in neurodisabilities
Authors: Bekkers Stijn , van Hulst Karen , Erasmus Corrie E. , Delsing Corinne P. , Scheffer Arthur R. T. , van den Hoogen Frank J. A. 
Published: February 2020

Abstract
Background
Drooling is dependent on various clinical variables. However, while drooling proves refractory to two-duct ligation in 40% of patients, predictors for treatment success are sparse and to date there is little evidence why some respond well while others are non-responders. We aim to find predictors for treatment success and study the effectiveness of two-duct ligation for drooling in neurodisabilities.

Methods
Fifty-four patients with moderate to severe drooling who had undergone two-duct ligation were screened for inclusion. Four patients were excluded due to missing or unreliable primary outcomes. The average age at the time of surgery was 12 years. Predictors were evaluated for treatment success which was defined as ≥ 50% visual analog scale for severity of drooling and/or drooling quotient reduction from baseline. Treatment effect was measured after 8 and 32 weeks compared to baseline.

Results
Age (more mature), adequate posture (no anteflexion), and normal speech are predictors for treatment success. Compared to baseline, drooling quotient was significantly lower at 8 (difference 18.6%, 95% confidence interval 12.3–24.9%) and 32 weeks (difference 10.1%, 95% confidence interval 3.9–16.4%). Compared to baseline, visual analog scale was significantly lower at 8 (difference 45.0, 95% confidence interval 37.0–52.9) and 32 weeks (difference 32.9, 95% confidence interval 25.0–40.7).

Conclusions
Age, adequate posture, and a normal speech are predictors for treatment success, are easily determined pre-operatively, and help the clinician providing patient-specific probability of treatment success. There is a significant subjective and objective decrease of drooling after two-duct ligation.
You are how you eat: differences in trophic position of two parasite species infecting a single host according to stable isotopes
Authors: Gilbert Beric M. , Nachev Milen , Jochmann Maik A. , Schmidt Torsten C. , Köster Daniel , Sures Bernd , Avenant-Oldewage Annemariè 
Published: February 2020

AbstractParasitism is commonly recognised as a consumer strategy, although, the interaction of parasites in communities and ecosystems are generally poorly understood. As parasites are integral parts of food webs, analysis of the trophic interactions between parasites and hosts was assessed through comparison of stable isotope ratios of carbon (13C/12C) and nitrogen (15N/14N). Largemouth yellowfish (Labeobarbus kimberleyensis) infected with the Asian tapeworm (Schyzocotyle acheilognathi) were collected from the Vaal Dam. Signatures of δ13C and δ15N were assessed in host muscle and liver tissue, and cestodes using an elemental analyser coupled with an isotope ratio-mass spectrometer (EA-IRMS). Hosts were enriched by 4.1‰ in the heavy nitrogen isotope with respect to the S. acheilognathi and therefore occupy a higher trophic position than the parasite. Comparison of δ13C indicates that dietary sources of carbon in cestodes are derived from the host liver. Comparison of stable isotope signatures between Paradiplozoon ichthyoxanthon (another common parasite of the Largemouth yellowfish in the Vaal River) and S. acheilognathi showed that the monogenean was enriched by 5.3‰ in 15N which accounts for a difference of almost two trophic positions. Isotope differences in the host–parasite system considered indicate that differences can be related to the mode of nutrient acquisition employed by host and parasites. Cestodes, being depleted in both 13C and 15N relative to the host and monogenean (P. ichthyoxanthon), indicate that S. acheilognathi assimilates nutrients derived from the host metabolism which are released from the liver.
Sources of uncertainty in the Mazama isopachs and the implications for interpreting distal tephra deposits from large magnitude eruptions
Authors: Buckland Hannah M. , Cashman Katharine V. , Engwell Samantha L. , Rust Alison C. 
Published: February 2020

AbstractEstimating the area of tephra fallout and volume of large magnitude eruptions is fundamental to interpretations of the hazards posed by eruptions of this scale. This study uses the tephra from the caldera forming eruption of Mount Mazama (Crater Lake, OR, USA) to demonstrate the challenges faced when working with large prehistoric tephra deposits and outlines the methodologies required to determine eruption volume and magnitude. We combine > 250 Mazama tephra occurrences, reported by a range of disciplines (including archaeology, paleoclimatology and volcanology), with new field studies to better understand the extent of the distal tephra. We find that the Mazama tephra has been remobilised to varying degrees over the past 7000 years, so each tephra locality was appraised for the likelihood that it records primary tephra fallout. We designated 45 of the distal (> 100 km from source) tephra sites as suitable for use in the production of isopachs using a spline fitting method. The new distal isopachs were then integrated with proximal fallout data and estimates of the ignimbrite volume from previous studies to revise the estimated bulk erupted volume from the climactic Mazama eruption to ~ 176 km3 (~ 61 km3 dense-rock equivalent; DRE). This study demonstrates the importance of collating tephra localities from a range of disciplines and that even remobilised deposits provide valuable information about the extent of the deposit. Interpreting remobilised deposits can provide insight into post-eruptive processes that could potentially pose secondary hazards following large magnitude eruptions. We also show that in some circumstances, remobilised deposits preserve important physical properties such as grain size.
Stable Matchings with Covering Constraints: A Complete Computational Trichotomy
Authors: Mnich Matthias , Schlotter Ildikó 
Published: February 2020

AbstractStable matching problems with lower quotas are fundamental in academic hiring and ensuring operability of rural hospitals. Only few tractable (polynomial-time solvable) cases of stable matching with lower quotas have been identified; most such problems are $$\mathsf {NP}$$NP-hard and also hard to approximate (Hamada et al. in Algorithmica 74(1):440–465, 2016). We therefore consider stable matching problems with lower quotas under a relaxed notion of tractability, namely fixed-parameter tractability. By cloning hospitals we focus on the case when all hospitals have upper quota equal to 1, which generalizes the setting of “arranged marriages” first considered by Knuth (Mariages stables et leurs relations avec d’autres problèmes combinatoires, Les Presses de l’Université de Montréal, Montreal, 1976). We investigate how a set of natural parameters, namely the maximum length of preference lists for men and women, the number of distinguished men and women, and the number of blocking pairs allowed determine the computational tractability of this problem. Our main result is a complete complexity trichotomy: for each choice of parameters we either provide a polynomial-time algorithm, or an $$\mathsf {NP}$$NP-hardness proof and fixed-parameter algorithm, or $$\mathsf {NP}$$NP-hardness proof and $$\mathsf {W}[1]$$W[1]-hardness proof. As corollary, we negatively answer a question by Hamada et al. (Algorithmica 74(1):440–465, 2016) by showing fixed-parameter intractability parameterized by optimal solution size. We also classify all cases of one-sided constraints where only women may be distinguished.
Determining the difference in the efficacy and safety of self-expandable metallic stents as a bridge to surgery for obstructive colon cancer among patients in the CROSS 0 group and those in the CROSS 1 or 2 group: a pooled analysis of data from two Japanese prospective multicenter trials
Authors: Ohki Takeshi , Yoshida Shuntaro , Yamamoto Masakazu , Isayama Hiroyuki , Yamada Tomonori , Matsuzawa Takeaki , Saito Shuji , Kuwai Toshio , Tomita Masafumi , Shiratori Toshiyasu , Shimada Mamoru , Hirakawa Tomio , Koizumi Koichi , Saida Yoshihisa 
Published: February 2020

Abstract
Purpose
This study compared the feasibility and safety of endoscopic placement of self-expandable metallic stents (SEMSs) as a bridge to surgery (BTS) between patients with obstructive colorectal cancer (CRC) classified as ColoRectal Obstruction Scoring System (CROSS) 0 and those with CROSS 1 or 2.

Methods
We conducted a post hoc analysis of two prospective, observational, single-arm multicenter clinical trials and performed a pooled analysis of the data. In total, 336 consecutive patients with malignant colorectal obstruction underwent SEMS placement. The primary endpoint was clinical success, defined as resolution of symptoms and radiological findings within 24 h. Secondary endpoints were technical success and adverse events.

Results
High clinical (98.0% vs. 98.4%) and technical (96.7% vs. 97.8%) success rates were observed in both groups (CROSS 0 vs. CROSS 1 or 2). The adverse event rate was low. The mean stricture length was lower (3.8 ± 1.2 cm vs. 4.4 ± 1.8 cm) and laparoscopic surgery more common (56.7% vs 52.2%) in the CROSS 0 group than in the CROSS 1 and 2 group.

Conclusion
This study was the first to compare the degree of stricture in different CROSS groups and demonstrated comparable results with respect to the short-term efficacy and safety of SEMS placement as a BTS for obstructive CRC in CROSS 0, 1, and 2 patients.
Dependence of odontogenic abscess on meteorological parameters: truth or myth?
Authors: Spalthoff S. , Jehn P. , Treptow K. , Zimmerer R. , Korn P. , Tavassol F. , Gellrich N.-C. , Dittmann J. 
Published: February 2020

Abstract
Objectives
It is still a common belief among dental practitioners that odontogenic abscesses are somehow linked to meteorological parameters. We investigated the influence of different meteorological parameters on the type of surgical abscess treatment (intra- versus extraoral incision) as a measure of the weather-dependent severity of infection.

Materials and methods
In this retrospective cohort study, we analyzed 841 patients who presented at our outpatient clinic with an odontogenic abscess between 2004 and 2013.

Results
We found no statistical dependence between intra- versus extraoral abscess incision with regard to temperature, atmospheric pressure, or relative air humidity. The annual distribution of abscesses was even, and the number of abscesses with greater or lesser mean values of each meteorological parameter did not differ significantly.

Conclusions
Our results showed no statistical relationship between meteorological parameters and intra- or extraoral abscess incisions.

Clinical relevance
Our analysis supports the assumption that the theorized relationship between odontogenic abscesses and meteorological parameters remains a myth.
Predictable quantum efficient detector for low optical flux measurements
Authors: Porrasmaa Santeri , Dönsberg Timo , Manoocheri Farshid , Ikonen Erkki 
Published: February 2020

AbstractThe predictable quantum efficient detector (PQED) is a primary standard of optical power, which utilizes two custom-made induced-junction photodiodes that are mounted in a wedged trap configuration for the reduction of reflectance losses. PQED photodiodes of p-type and n-type were characterized for their dark current dependence on reverse bias voltage at room temperature. As simulations predict that the dark current will decrease exponentially with temperature, the temperature dependence of dark current for the n-type photodiodes was also measured. Two n-type induced-junction photodiodes were assembled inside a liquid nitrogen cryostat. The results from the dark current measurements indicate that the cooled n-type photodiodes are suitable for measuring optical fluxes in the few photon regime. A photon flux of approximately 7,000,000 photons per second was measured using the PQED at a cryogenic temperature with a relative standard uncertainty of 0.15%. The results support the utilization of the PQED as a primary standard of optical power in single and few photon applications.
Predicting scattering properties of fiber suspensions using Mie theory and probabilistic cross-sectional diameter of fibers
Authors: Juttula Harri J. , Törmänen Matti , Mäkynen Anssi J. 
Published: February 2020

AbstractScattering of visible light by micrometer-scale natural wood fibers is usually treated by assuming fibers to be perfect long cylindrical scatterers. In industrial processes, however, fibers experience deformations and are far from ideal cylinders. Variation in fiber morphology affects their scattering properties and it poses a challenge for reliable process measurements. In this paper, we have studied experimentally scattering of both deformed natural and ideal artificial non-absorbing fibers in aqueous suspension and their response to mass concentration of fibers. Experimental results are compared with the predictions of the Mie theory which is combined with cross-sectional diameter probability distribution of fibers. It is shown that the diameter distribution of the fibers together with Mie theory provides results that agree with experiments in case of both natural and ideal fibers.
The Antipsychotic Medication Management Fidelity Scale: Psychometric properties
Authors: Ruud Torleif , Drivenes Karin , Drake Robert E. , Haaland Vegard Øksendal , Landers Matthew , Stensrud Bjørn , Heiervang Kristin S. , Tanum Lars , Bond Gary R. 
Published: February 2020

AbstractThe paper describes the Antipsychotic Medication Management Fidelity Scale and its psychometric properties, including interrater reliability, frequency distribution, sensitivity to change and feasibility. Fidelity assessors conducted fidelity reviews four times over 18 months at eight sites receiving implementation support for evidence-based antipsychotic medication management. Data analyses shows good to fair interrater reliability, adequate sensitivity to change over time and good feasibility. At 18 months, item ratings varied from poor to full fidelity on most items. Use of the scale can assess fidelity to evidence-based guidelines for antipsychotic medication management and guide efforts to improve practice. Further research should improve and better calibrate some items, and improve the procedures for access to information.Trial registration: ClinicalTrials.gov Identifier: NCT03271242.
Using genetics to inform restoration and predict resilience in declining populations of a keystone marine sponge
Authors: Griffiths Sarah M. , Taylor-Cox Evelyn D. , Behringer Donald C. , Butler Mark J. , Preziosi Richard F. 
Published: February 2020

AbstractGenetic tools can have a key role in informing conservation management of declining populations. Genetic diversity is an important determinant of population fitness and resilience, and can require careful management to ensure sufficient variation is present. In addition, population genetics data reveal patterns of connectivity and gene flow between locations, enabling mangers to predict recovery and resilience, identify areas of local adaptation, and generate restoration plans. Here, we demonstrate a conservation genetics approach to inform restoration and management of the loggerhead sponge (Spheciospongia vesparium) in the Florida Keys, USA. This species is a dominant, habitat-forming component of marine ecosystems in the Caribbean region, but in Florida has suffered numerous mass mortality events. We developed microsatellite markers and used them to genotype sponges from 14 locations in Florida and a site each in The Bahamas, Belize and Barbuda. We found that genetic diversity levels were similar across all sites, but inbreeding and bottleneck signatures were present in Florida. Populations are highly structured at the regional scale, whilst within Florida connectivity is present in a weak isolation by distance pattern, coupled with chaotic genetic patchiness. Evidence of a weak barrier to gene flow was found in Florida among sites situated on opposite sides of the islands in the Middle Keys. Loggerhead sponge populations in Florida are vulnerable in the face of mass mortalities due to low connectivity with other areas in the region, as well as distance-limited and unpredictable local connectivity patterns. However, our discovery of Florida’s high genetic diversity increases hope for resilience to future perturbations. These results provide valuable insight for sponge restoration practice in Florida.
The Novel Transcription Factor CREB3L4 Contributes to the Progression of Human Breast Carcinoma
Authors: Pu Qian , Lu Li , Dong Ke , Geng Wen-wen , Lv Yan-rong , Gao Hai-dong 
Published: February 2020

AbstractBreast carcinoma(BC)is the most common cancer type among females globally. Understanding the molecular pathways that trigger the development of BC is crucial for both prevention and treatment. As such, the role of transcription factors (TFs) in the development of BC is a focal point in this field. CREB3s play a critical role in initiating the unfolded protein response (UPR); however, the role of CREB3 family members in breast cancer development remains largely unknown. Here, we mined the ONCOMINE database for the transcriptional data of CREB3s in patients with BC. Then, the regulatory functions of a novel TF, CREB3L4, were investigated. CREB3L4 knockdown in MDA-MB-231 and MCF-7 cells suppressed proliferation and promoted apoptosis and cell cycle arrest. ChIP assays confirmed that CREB3L4 can directly bind to the PCNA promoter region, suggesting that the PCNA protein may be functionally downstream of CREB3L4. Additionally, the expression level of CREB3L4 was assessed using our cohort. CREB3L4 is upregulated in breast cancer tissues and is significantly associated with histological grade and tumour size (P = 0.001 andP < 0.001, respectively). Furthermore, PCNA expression was upregulated in breast cancer tissues and positively correlated with CREB3L4. In summary, CREB3L4 may play an important role in the progression of human BC and may serve as a therapeutic target.
Predicting Long-Term Sickness Absence and Identifying Subgroups Among Individuals Without an Employment Contract
Authors: Louwerse Ilse , van Rijssen H. Jolanda , Huysmans Maaike A. , van der Beek Allard J. , Anema Johannes R. 
Published: February 2020

AbstractPurpose Today, decreasing numbers of workers in Europe are employed in standard employment relationships. Temporary contracts and job insecurity have become more common. This study among workers without an employment contract aimed to (i) predict risk of long-term sickness absence and (ii) identify distinct subgroups of sick-listed workers. Methods 437 individuals without an employment contract who were granted a sickness absence benefit for at least two weeks were followed for 1 year. We used registration data and self-reported questionnaires on sociodemographics, work-related, health-related and psychosocial factors. Both were retrieved from the databases of the Dutch Social Security Institute and measured at the time of entry into the benefit. We used logistic regression analysis to identify individuals at risk of long-term sickness absence. Latent class analysis was used to identify homogenous subgroups of individuals. Results Almost one-third of the study population (n = 133; 30%) was still at sickness absence at 1-year follow-up. The final prediction model showed fair discrimination between individuals with and without long-term sickness absence (optimism adjusted AUC to correct for overfitting = 0.761). Four subgroups of individuals were identified based on predicted risk of long-term sickness absence, self-reported expectations about recovery and return to work, reason of sickness absence and coping skills. Conclusion The logistic regression model could be used to identify individuals at risk of long-term sickness absence. Identification of risk groups can aid professionals to offer tailored return to work interventions.