bluuebunny/crossref_metadata_2025_split huggingface dataset:
NHS sickness absence in England: hidden patterns
Authors: Jones Rodney P 
Published: April 2020

Background/aims Long-term trends in sickness absence have until now been assumed to be caused by economic cycles, age and gender changes in the workforce, and the success or failure of employers to reduce common causes of absence. This study aimed to identify unexplained patterns in sickness absence data. Methods A rolling 12-month average of sickness absence was used covering the 12 months ending March 2010 through to the 12 months ending October 2019. To determine the largest step increase in sickness absence, the average sickness absence rate was compared between successive 12-month periods. Results Time and space (spatiotemporal) patterns of up/down shifts are evident in the regional data across England. Over the 10-year period of the study, these patterns, rather than schemes to reduce sickness absence, appear to dominate the trend, which has shown no evidence of a change in the long-term average. Conclusions A rolling 12-month average, or more sophisticated methodologies, is required to detect and investigate less obvious spatiotemporal patterns in sickness absence data. Further research is required to investigate the causes of the up/down patterns observed in this data, which may be influencing sickness absences among NHS staff and wider health trends.
Patterns of sickness absence from a secondary hospital in Melbourne: a 10-year longitudinal study
Authors: Krejany Catherine , Gaedtke Lee , Kanjo Epi , Jiwa Moyez 
Published: April 2020

Background/aims There has been significant concern in recent years regarding increases in absenteeism in the healthcare sector, leading to lost productivity and projected workforce shortages. This study aimed to identify patterns of sickness absence over a 10-year period in a single-site secondary hospital in Melbourne, Australia. Methods Data regarding sickness absences were extracted from anonymised payroll records from 2007 to 2016. The patterns of sickness absence analysed included seasonality, amount of leave and category of leave. These were explored both for individuals and in the aggregate. Results: Compared to the Australian average of 9.7 days, this cohort of employees took less sick leave, averaging at 8.81 days each. As a group, a consistent proportion of staff took no sick leave, 1–3 days, 4–6 days, or 7–9 days each year in the 10-year timespan. Only a small proportion took more than 9 days of sickness leave per year. Conclusions The pattern of leave-taking was consistent for the group as a whole, however, individual leave patterns vary.
Disturbed partial discharge detection system based on an improved Φ-OTDR assisted by a wFBG array
Authors: Zhu Peng , Wen Hongqiao , Che Qian , Li Xinyu 
Published: April 2020

Partial discharge (PD) detection is an effective method for evaluating the insulation status of power cables. In this paper, a disturbed acoustic sensing (DAS) system based on phase-sensitive optical time-domain reflectometry (

Φ

-OTDR) for online PD detecting is proposed and demonstrated. To detect the ultra-small fiber strain induced by PD, a weak fiber Bragg grating (wFBG) array is introduced into the sensing fiber to increase signal-to-noise ratio (SNR) of the system. Besides, the sensing fiber is packaged with aluminum tape to enhance the sensitivity. Consistent PD signals in a 10 kV cross linked polyethylene (XLPE) power cable with artificial defects have been observed, and characteristics of the signals are analyzed.
DMD-based three-dimensional chromatic confocal microscopy
Authors: Li Shaobai , Liang Rongguang 
Published: April 2020

In this paper, a digital mirror device (DMD)-based chromatic confocal microscopy is proposed and demonstrated for three-dimensional (3D) surface profiling without any mechanical scanning. In this method, the DMD works as the multipoint source and multi-pinhole at the same time to achieve the lateral scanning. Moreover, axial scanning is realized through the chromatic aberration of the confocal optics. Since the micromirror array of the DMD is not perpendicular to the confocal imaging axis, a corresponding calibration is needed to eliminate the tilt effects and perform accurate 3D imaging. The measurement range with the current optical system is 45 µm over 505–650 nm working spectrum and can be increased by using a custom objective with large chromatic aberration. The system performance has been demonstrated with a multistep sample.
A DECORAÇÃO “AO ROMANO” E A PRESENÇA DE JOÃO DE RUÃO NA TUMULÁRIA DE GÓIS E TROFA DO VOUGA.
Authors: Vaz Ana Margarida , Pereira Gabriel 
Published: April 2020

Os monumentos fúnebres de D. Luís da Silveira e de D. Duarte de Lemos, respetivamente em Góis e na Trofa do Vouga, revelam-se obras indissociáveis devido à forma como os encomendantes surgem representados. A generalidade dos autores reconheceu as proximidades entre as duas obras, porém tenderam a ignorar a componente decorativa e é esta, na ausência de nova documentação, que constitui o principal meio de identificação e descodificação de autorias.
Aqui, pretendem-se trazer à luz a natureza do ornamento e a decoração presente na tumulária e mostrar como ela obedece à mesma cultura plástica irradiada pelo Renascimento coimbrão, ainda que com trabalho de qualidade díspar – fruto da forma distinta como João de Ruão se envolveu nos dois projetos.
Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study
Authors: Pan Lei , Mu Mi , Yang Pengcheng , Sun Yu , Wang Runsheng , Yan Junhong , Li Pibao , Hu Baoguang , Wang Jing , Hu Chao , Jin Yuan , Niu Xun , Ping Rongyu , Du Yingzhen , Li Tianzhi , Xu Guogang , Hu Qinyong , Tu Lei 
Published: April 2020

OBJECTIVE:
Since the outbreak of Coronavirus Disease 2019 (COVID-19) in December 2019, various digestive symptoms have been frequently reported in patients infected with the virus. In this study, we aimed to further investigate the prevalence and outcomes of COVID-19 patients with digestive symptoms.

METHODS:
In this descriptive, cross-sectional, multicenter study, we enrolled confirmed patients with COVID-19 who presented to 3 hospitals from January 18, 2020, to February 28, 2020. All patients were confirmed by real-time polymerase chain reaction and were analyzed for clinical characteristics, laboratory data, and treatment. Data were followed up until March 18, 2020.

RESULTS:
In the present study, 204 patients with COVID-19 and full laboratory, imaging, and historical data were analyzed. The average age was 52.9 years (SD ± 16), including 107 men and 97 women. Although most patients presented to the hospital with fever or respiratory symptoms, we found that 103 patients (50.5%) reported a digestive symptom, including lack of appetite (81 [78.6%] cases), diarrhea (35 [34%] cases), vomiting (4 [3.9%] cases), and abdominal pain (2 [1.9%] cases). If lack of appetite is excluded from the analysis (because it is less specific for the gastrointestinal tract), there were 38 total cases (18.6%) where patients presented with a gastrointestinal-specific symptom, including diarrhea, vomiting, or abdominal pain. Patients with digestive symptoms had a significantly longer time from onset to admission than patients without digestive symptoms (9.0 days vs 7.3 days). In 6 cases, there were digestive symptoms, but no respiratory symptoms. As the severity of the disease increased, digestive symptoms became more pronounced. Patients with digestive symptoms had higher mean liver enzyme levels, lower monocyte count, longer prothrombin time, and received more antimicrobial treatment than those without digestive symptoms.

DISCUSSION:
We found that digestive symptoms are common in patients with COVID-19. Moreover, these patients have a longer time from onset to admission, evidence of longer coagulation, and higher liver enzyme levels. Clinicians should recognize that digestive symptoms, such as diarrhea, are commonly among the presenting features of COVID-19 and that the index of suspicion may need to be raised earlier in at-risk patients presenting with digestive symptoms. However, further large sample studies are needed to confirm these findings.
Development of an algorithm for the identification of leukemic hematolymphoid neoplasms in Primary Care patients
Authors: Quirós Covadonga , Fonseca Ariana , Alonso-Álvarez Sara , Moro-García Marco Antonio , Alonso-Arias Rebeca , Morais Lucía-Rita , Álvarez-Menendez Francisco V. , Colado Enrique 
Published: April 2020

Abstract

Background
Diagnosis of hematolymphoid neoplasm (HLN) requires different technologies which are performed on a patient basis instead of per protocol. We hypothesize that integration of hematimetric and cytological analysis along with multiparametric flow cytometry (MFC) provides a framework to evaluate peripheral blood (PB) samples from Primary Care.

Methods
Samples from patients with persistent (>3 months) lymphocytosis (>5 × 109/L) and/or monocytosis (>109/L) or the presence of atypical and/or blast cells upon the smear review were analyzed by MFC concurrent to cytological analysis. MFC studies were carried out following standardized procedures.

Results
In a 3-year period, smear review and MFC were performed simultaneously in 350 samples, demonstrating HLN in 194 cases (55.4%). In 156 cases, reactive cell populations were found. The combination of age, absolute lymphocyte count (ALC), hemoglobin and platelets provided the best correlation with MFC for the presence of a chronic lymphoproliferative disorder (CLPD) in lymphocytosis [area under the curve (AUC) 0.891, p < 0.05]. A model evaluating the probability of CLPD has been proposed and validated in an independent cohort.

Conclusions
A strategy to perform MFC studies following standardized procedures has proven to be useful to evaluate samples from patients in Primary Care centers for HLN diagnosis or reactive conditions, providing a sensitive and rapid clinical orientation and avoiding unnecessary consultations in routine clinical practice. The probability for the presence of CLPD in PB can be calculated and help guide decision-making regarding further testing.
Comparison Between Linear and Nonlinear Governor Power Flow Formulations
Authors: Passos Filho João Alberto , Ferreira Avila Othon , Oliveira La Gatta Paula 
Published: April 2020

AbstractThe main objective of this paper is to review and compare two methodologies to solve the power flow problem considering active power generation droop control. The first methodology is based on a DC power flow model, and the second one is based on a conventional full Newton power flow formulation. The study of two test systems is used to validate the proposed analysis; the first one is the 11-bus system with two distinct areas, and the second one is the 39-bus New England power system. The results presented validate and indicate the effectiveness of the DC power flow approach in order to estimate the steady-state system frequency deviations.
Ethnobotanical survey of three members of family Lamiaceae among the inhabitants of Bejaia, Northern Algeria
Authors: Khaled-Khodja Nabyla , Brahmi Fatiha , Madani Khodir , Boulekbache-Makhlouf Lila 
Published: April 2020

Abstract

Background
This paper presents the uses of Calamintha nepeta, Teucrium flavum and Thymus numidicus in food and in traditional herbal medicines in six districts from Bejaia state, Northern Algeria.

Materials
A semi-structured interview was conducted to 52 informants, including questions on the demographic data of the informants and uses of the three medicinal plants to determine the alimentary and the medicinal uses of these plants in Bejaia state.

Results
The demographic data of the informants indicate that rural participants are the principal consumers of medicinal plants. Data regarding experience of medicinal plants preparation show that 36.5% was confined to the experienced informants, while 63.5% of the informants were inexperienced. Women used medicinal plants more frequently than men; it is recorded that there were 42.3% male informants and 57.7% female informants. Studied plants were used for curing a total of 10 diseases. Also, C. nepeta and T. numidicus were applied as condiment in food, but T. flavum was found to have no food uses in all districts.

Conclusion
Bejaia district is rich in biodiversity of food and medicinal plants and there is need for further studies to validate their use as potential drugs.
Effect of pre-cesarean foot reflexology massage on anxiety of primiparous women
Authors: Navaee Maryam , Khayat Samira , Abed Zahra Ghadiri 
Published: April 2020

Abstract

Introduction
Anxiety is a common feeling in cesarean section and lack of attention to it is associated with negative consequences for health of mother and child. Reflexology is a way to reduce anxiety. So far, the effect of reflexology on pre-cesarean anxiety has not been evaluated. Therefore, we aimed to evaluate the effect of pre-cesarean foot reflexology massage on the anxiety of women during their first pregnancy.

Materials and Methods
This study is a three-group clinical trial that was conducted in 2019. The study sample consisted of 90 pregnant women hospitalized for cesarean section in Zahedan who were randomly divided into three groups of 30 women. The subjects completed the state section of Spielberger anxiety questionnaire. The control group did not receive any intervention. For two groups, 1 h before surgery, a group received reflexive massage, and the another group simple massage. Duration of massage for each group was 30 min. After 30 min, the subjects completed the state section of Spielberger questionnaire again. Statistical analysis was performed by SPSS software program, version 21.0. ANOVA and ANCOVA tests were used to compare between groups and paired t-test was used for intra-group comparisons.

Results
The results showed that the level of anxiety was significantly reduced in the reflexology massage group (from 55 ± 8 to 40 ± 7) as well as simple massage group (from 51 ± 10 to 47 ± 7) (p<0.001). In the control group, anxiety was increased (from 49 ± 9 to 56 ± 9) (p<0.001). Comparison between the three groups by ANCOVA indicated that reflexology massage and simple massage significantly decreased anxiety scores (p>0.001 and p>0.001,respectively). Reflexive massage significantly reduced anxiety scores (p>0.001) as compared to simple massage.

Conclusion
The results of this study revealed the positive effect of reflexology massage on pre-cesarean anxiety. Because reflexology massage is an inexpensive, simple, and easy approach, the use of this non-pharmaceutical method is recommended to reduce pre-cesarean anxiety.
Evaluation of subacute toxicity and herb–drug interaction potential of an herbal Arishta formulation
Authors: Dey Amitabha , Kanjilal Satyajyoti , Bhatt Bibhuti N , Mohapatra Satyabrata , Chakraborty Tulika , Bhide Ranjit , Narwaria Avinash , Katiyar Chandra K 
Published: April 2020

Abstract

Background

Arishta technology is an age-old heritage and uses herbal decoctions to prepare self-generated alcoholic medicines. In Ayurveda, Arishta preparations are widely used as a remedy for metabolic disorders. However, their safety and influence on herb metabolism pathways were not yet explored. Aim: To study the subacute toxicity of a polyherbal Arishta formulation (coded as DB-07) in rats and to evaluate its potential for inhibition of the drug-metabolizing enzyme (Cytochrome P450 3A4).

Methodology
Experimentally naive rats were treated with graded oral doses of DB-07 (10 and 20 mL/kg/day) for 28 days. During the course of the experiment, all the animals were closely observed for apparent behavioural abnormalities and mortalities. Tissue histology was performed to assess any sign of toxicity. In addition, in vitro CYP3A4 inhibition assay was performed to study the effect on drug metabolism pathways.

Results
Animals did not show any change in body weight, organ toxicity and food consumption throughout the dosing period of 28 days. Pathophysiological, behavioural status and locomotor activity were not altered. DB-07 did not inhibit CYP3A4 enzyme and drug metabolism pathway in-vitro. Gallic acid and quercetin were identified as phytomarker from the formulation that may be responsible for its activity related safety issue.

Conclusion
These results indicate that use of DB-07 may be safe with no sign of toxicity for up to 28 days in rats. Further, CYP3A4 inhibition assay indicated that DB-07 is less likely to have herb–drug interactions when concomitantly administered with CYP3A4 inhibitors or inducer.
The effect of concurrent resistance-aerobic training on serum cortisol level, anxiety, and quality of life in pediatric type 1 diabetes
Authors: Nazari Marzieh , Shabani Ramin , Dalili Setila 
Published: April 2020

AbstractBackgroundGiven the importance of anxiety and quality of life for the mental health of children with type 1 diabetes (T1D), exercise prescription can be of crucial significance. The present study aims to explore the effect of concurrent resistance-aerobic training on serum cortisol level, anxiety, and quality of life among pediatric T1D.MethodsForty children (aged 8–14 years) were randomly assigned to experimental (n = 20) and control groups (n = 20) for 16 weeks. The exercise training program was composed of 16 weeks of interval concurrent resistance-aerobic training with a duration of 60 min performed three times a week. The subjects first performed the resistance training (20 min of Pilates exercises and 20 min of body weight-bearing exercises). Then, the aerobic exercises were performed with an intensity of 50–75% of maximum heart rate. Before and after the training, blood tests including cortisol were carried out on the subjects by RIA kit. Anxiety and quality of life were measured by the Revised Children’s Manifest Anxiety Scale (RCMAS) and Pediatric Quality of Life (PedsQL), respectively. Body composition was measured by InBody. Data were analyzed by paired and independent t-test at p < 0.05 significance level.ResultsSixteen weeks of concurrent resistance-aerobic exercise significantly reduced the anxiety index (p = 0.001) and increased the quality of life (p = 0.003). Although the cortisol index was increased, it did not reveal any significant differences between the experimental and control groups (p = 0.781). No significant differences were observed in the indices of quality of life, anxiety, and cortisol in the control group.ConclusionsA 16-week program of concurrent resistance-aerobic training can improve the quality of life and anxiety among children suffering from T1D, but it may not influence the cortisol level (p > 0.05).
Multi-objective optimization of injection-molded plastic parts using entropy weight, random forest, and genetic algorithm methods
Authors: Cao Yanli , Fan Xiying , Guo Yonghuan , Li Sai , Huang Haiyue 
Published: April 2020

Abstract
The qualities of injection-molded parts are affected by process parameters. Warpage and volume shrinkage are two typical defects. Moreover, insufficient or excessively large clamping force also affects the quality of parts and the cost of the process. An experiment based on the orthogonal design was conducted to minimize the above defects. Moldflow software was used to simulate the injection process of each experiment. The entropy weight was used to determine the weight of each index, the comprehensive evaluation value was calculated, and multi-objective optimization was transformed into single-objective optimization. A regression model was established by the random forest (RF) algorithm. To further illustrate the reliability and accuracy of the model, back-propagation neural network and kriging models were taken as comparative algorithms. The results showed that the error of RF was the smallest and its performance was the best. Finally, genetic algorithm was used to search for the minimum of the regression model established by RF. The optimal parameters were found to improve the quality of plastic parts and reduce the energy consumption. The plastic parts manufactured by the optimal process parameters showed good quality and met the requirements of production.
A consistent model for the key complex in chronic beryllium disease
Authors: Berger Raphael J.F. , Håkansson Pär , Mera-Adasme Raúl 
Published: April 2020

Abstract
A hypothesis on the structure of the key complex in chronic beryllium disease (CBD) is discussed with respect to the current knowledge on CBD, and with respect to the constraints implied by the coordination chemistry of beryllium and experimental data on the engaged protein complexes. The structure hypothesis is based on the [Be4O]6+ moiety as a coordination center, which is also found in the so called “basic beryllium carboxylates”. The structure of a small molecular model, optimized at the DFT level of theory, is used to compare the structural demands of this coordination center with a structure of the in vitro model of a beryllium immunoprotein complex determined previously by protein crystallography (Clayton & al., Cell
2014, 158, 132). 9Be NMR chemical shielding values, quadrupole coupling constants and asymmetry parameters (η) have been calculated.
Myopathy secondary to empagliflozin therapy in type 2 diabetes
Authors: Gao Frank , Hall Stephen , Bach Leon A 
Published: April 2020

Summary
Sodium/glucose co-transporter 2 (SGLT2) inhibitors are novel oral hypoglycaemic agents that are increasingly used in the management of type 2 diabetes mellitus (T2DM). They are now recommended as second-line pharmacotherapy (in conjunction with metformin) in patients with type 2 diabetes and established atherosclerotic heart disease, heart failure or chronic kidney disease due to their favourable effects on cardiovascular and renal outcomes. We report a case of a 69-year-old man who developed muscle pain, weakness and wasting after commencing the SGLT2 inhibitor empagliflozin. This persisted for 1 year before he underwent resistance testing, which confirmed muscle weakness. His symptoms resolved within weeks of ceasing empagliflozin, with improvement in muscle strength on clinical assessment and resistance testing and reversal of MRI changes. No other cause of myopathy was identified clinically, on biochemical assessment or imaging, suggesting that empagliflozin was the cause of his myopathy.

Learning points:

Empagliflozin, a commonly used SGLT2 inhibitor, was associated with myopathy.

A high degree of suspicion is required to diagnose drug-induced myopathy, with a temporal relationship between starting the medication and symptom onset being the main indicator.

Recognition of drug-induced myopathy is essential, as discontinuation of the offending drug typically improves symptoms.