bluuebunny/crossref_metadata_2025_split huggingface dataset:
Existence of Outdoor Reklame Assessed from The Estethics of The Public Space in Teuku Umar Denpasar
Authors: Adistanaya I Gusti Bagus 
Published: October 2020

The rise of trade and service competition affects the emergence of various promotional media whose existence is placed in strategic spaces in urban centers that cause discomfort and decreased quality of the beauty of the city. This study aims to examine the typology of outdoor signage, public perception of the existence of outdoor signage and its influence on the aesthetics of public space. Data collection is done through a qualitative (descriptive) approach. Descriptive qualitative analysis techniques are used to describe and explain certain phenomena using descriptions, explanations and understandings. In this research activity, descriptive qualitative analysis techniques are used to explain the general picture and the results of interviews so that the analysis conducted must be able to produce output in accordance with the goals and objectives set. The results of the analysis show that the advertisement characteristics in the public spaces of Teuku Umar Denpasar street are dominated by commercial outdoor signage. Respondents' perceptions of the existence of outdoor billboards showed (66%) assessed that billboards had not created city order, (60%) assessed that they had not created city beauty, (80%) rated size as inappropriate, (74%) assessed attractive colors, (77%) rate disturbing lighting and (86%) rate disturbing the building facade as big as. From the results of the analysis, regulations are needed to bring order to reinstall outdoor billboards in order to create order and beauty of the city of Denpasar.
Index Terms— outdoor billboards, aesthetics, public space
Mapping Analysis of Conflict Potential Utilization of Coastal Area Desa Pangkung Tibah, Kediri, Tabanan
Authors: Purba I Gde Putu Bayu Raka , Rajendra , I Gusti Ngurah Anom , Agusintadewi Ni Ketut 
Published: October 2020

Pangkung Tibah Village is located in the southern coastal area of Bali Island. About 70 percent of the land area in this village has been ruled by investors for tourist accommodation, especially the area close to the beach. At the beginning, land acquisition plans were not well received by local villagers, but other approaches were made by investors, including involving security forces to force citizens to surrender their lands. Field data reveals various problems, such as land of citizens that are isolated without access in the land of investors, land use that is not proprietary, the potential destruction of the environment, actions that cause citizens to feel uncomfortable. This research aims to map the potential conflicts of coastal utilization of the village. The method used is a qualitative approach. Primary data collection is done by in-depth interviews with relevant informant and field observations. The results of the study identified land utilization perpetrators, potentially conflict locations, conflicting causes, conflict forms, level conflicts to date, and mapping potential conflicts of mild, moderate, and severe conflict levels. Potential conflict mapping analysis is based on territorial theory and conflict theory. Thus, the results of this research can be used as a basis for consideration by policy determinants (Government and indigenous leaders) to overcome the potential conflict of coastal utilization by coordinating the research results with Spatial planning and coastal area management strategies for sustainable economic, social and environmental development in research locations.
Index Terms— conflicts, coastal utilization, mapping, potential conflicts, coastal areas
POTENSI KOMBINASI MEMANTIN DAN FITOMELATONIN DARI EKSTRAK BIJI BUNCIS (PHASEOLUS VULGARIS L) TERENKAPSULASI NANO-CHELATOR SEBAGAI INHIBITOR AGREGASI β-AMILOID DAN ANTIOKSIDAN : MODALITAS KURATIF MUTAKHIR PADA PENDERITA ALZHEIMER
Authors: Arrasyid Raafi Haidar , Kumala Endah Sari Ratna , Afnan Nisrina Hanifah 
Published: October 2020

Alzheimer merupakan penyakit yang menyerang sistem saraf pusat manusia dengan tanda adanya atrofi dan kematian saraf pada beberapa regio di otak. Data dari World Health Orginazation (WHO) pada tahun 2017 menunjukkan angka penderita Alzheimer mencapai 50 juta orang dan di Indonesia mencapai 1,2 juta orang. Tatalaksana yang ada saat ini belum dapat mengobati Alzheimer secara menyeluruh dan tingginya ketidakpatuhan pasien dalam menjalani pengobatannya membuat angka penderita Alzheimer tetap tinggi. Mengetahui kombinasi memantin dan fitomelatonin yang terenkapsulasi nano-chelator sebagai terapi kuratif Alzheimer. Metode yang digunakan adalah studi literatur. Penulis menganalisis sumber-sumber terkait yang mayoritas berasal dari jurnal yang diambil dari PubMed, Science Direct, dan Spinger. Memantin merupakan obat yang telah dipakai dalam pengobatan Alzheimer dengan memblok reseptor NMDA sehingga melindungi sel saraf dari reaksi inflamasi dan menghambat pembentukan agregasi β-Amilod. Namun, penggunaan satu bahan tersebut tidak dapat menunjukkan hasil yang maksimal. Oleh karena itu, penulis mengkombinasikan memantine dengan fitomelatonin yang didapatkan dari buncis (Phaseolus vulgaris L) dengan peran sebagai antioksidan dan mengurangi agregasi β- Amilod melalui jalur yang berbeda dari memantin. Untuk meningkatkan bioavabilitas, ketepatan terapi, dan kemampuan menembus Blood-Brain Barrier (BBB) dari kedua bahan tersebut maka digunakanlah nano-chelator. Melalui efek penghambatan pembentukan agregasi β- Amilod dan antioksidan dari kombinasi memantin dan melatonin dengan enkapsulasi nano- chelator diharapkan terapi Alzheimer dapat lebih efektif dan efisien.
POTENSI KOMBINASI INDUCED PLURIPOTENT STEM CELL-DERIVED NEURAL PROGENITOR CELL (IPSC-NPC) DENGAN HIDROGEL CHONDROITIN SULFATE SCAFFOLDS YANG MEMEDIASI BASIC FIBROBLAST GROWTH FACTOR (BFGF) SEBAGAI INOVASI TERAPI TERBARU STROKE ISKEMIK
Authors: Sisca Sisca , Azizah Nurul , Al Aldi M. Salas 
Published: October 2020

Stroke iskemik adalah jenis stroke yang paling umum terjadi dan merupakan penyakit dengan angka kematian dan kecacatan tertinggi di dunia. Terapi yang ada saat ini dalam menangani stroke masih menyisakan tantangan bagi para peneliti karena belum ditemukannya perawatan yang dapat meregenerasi jaringan otak yang hilang akibat infark. Penggunaan Neural Progenitor Cell (NPC) turunan induced Pluripotent Stem Cell (iPSC) merupakan studi yang berada paling depan dalam tahapan uji praklinis karena diketahui dapat menjadi dan menggantikan neuron serta mempromosikan mekanisme pemulihan endogen seperti angiogenesis. Namun, terdapat hambatan dari penggunaan NPC utamanya pada patofisiologi stroke yang menyebabkan adanya resistensi terhadap terapi seluler. Oleh karena itu, diperlukan kombinasi NPC dengan Scaffold menggunakan Chondroitin sulfate-A (CS-A) berbasis hidrogel yang dapat meningkatkan aliran darah ke inti stroke serta meningkatkan afinitas neurotropik. Kombinasi ini menghasilkan sinergitas terapi yang sangat baik dengan efek utamanya dimediasi oleh basic Fibroblast Growth Factor (bFGF) yang akan memperbaiki kerusakan jaringan di daerah infark. Untuk mengetahui potensi kombinasi NPC dengan Hidrogel CS-A dalam pengobatan stroke iskemik. Literature Review ini disusun menggunakan metode studi pustaka dengan mengumpulkan jurnal yang valid berdasarkan kriteria inklusi dan eksklusi khusus. Kombinasi NPC dengan Hidrogel CS-A secara signifikan meningkatkan perbaikan vaskular, aliran darah kortikal dan hasil perilaku sensorimotor setelah stroke. Peningkatan yang terjadi dimediasi melalui stimulasi pengeluaran bFGF yang mendorong perbaikan jaringan. Efektivitas pemberian NPC secara signifikan dapat ditingkatkan dengan kombinasi Hidrogel CS-A dan telah terbukti dalam berbagai pengujian sehingga diharapkan dapat menjadi upaya terbaru dalam terapi stroke iskemik.
CAN INCREASED MONOCYTE / LYMPHOCYTE RATIO BE USED AS AN INDICATOR FOR ALZHEIMER'S DISEASE?
Authors: Bolayır Aslı 
Published: October 2020

Background: The monocyte to lymphocyte ratio (MLR) obtained by dividing the number of monocytes by lymphocyte number is considered as a new marker of inflammation. The role of MLR in Alzheimer's disease (AD) has not been clearly understood yet. So, the aim of this study is to determine the role of MLR in the pathogenesis of AD.
Method: Our study is a single centered retrospective study. 254 patients with AD, who applied to our clinic between January 2013 and December 2017 and 256 healthy control with similar age and sex were included to this study.
Results: While lymphocyte count was lower in the control group; MLR values were higher in the patient group. The patient group was then divided into three subgroups according to the results of standardized mini mental test (SMMT). MLR values increased in parallel with the severity of AD. In addition, ROC analysis revealed that MLR values above 0.28 can be used as a marker of the development of AD (AUC: 0.76, 95% CI: 0.66–0.87, sensitivity: 73.1%, specificity of 81.1%).
Conclusions: This study demonstrated the role of MLR in the inflammatory process, thought to be responsible for the development of AD.
THE ROLE OF DECENTRALIZATION AND LOCAL ACTION IN THE CONTEXT OF GLOBALIZATION
Authors: Guamba José Manuel Elija 
Published: October 2020

This article aims to analyze some of the processes that contributed to the emergence of theorizing about local development, namely, the Keynesian model crisis and aggravated social problems after the fall of the welfare State, globalization, and the role local action, decentralization and local government in the process of seeking of local development with the participation of civil society.
Among the factors that contributed to the social crisis that led to the emergence of new theories of development, we have the collapse of the welfare State and the process that ended in neo-liberalism and globalization. It was in this context that new social actors with a new paradigm, that and the Local development process. Thus, arises the civil society, composed of entities that aim to develop through socio-economic dimension alternatives and environmental preservation.
The process of globalization has not solved the social and economic problems of the contemporary world, in contrast, has contributed to further increase the differences between developed countries and those in development, leading many times, the growth of poverty and social exclusion. On the other hand, he is responsible for a process of local development institutions, bringing new perspectives to the adequacy of national public policies at regional/local peculiarities and the urban and rural spaces, in your physical, economic dimension, social and cultural.
This process comes calling into question many traditional structures and public institutions as to your fitness and your performance in the management of economic and social policies, creating a dichotomy arising out of the policy challenges for the construction of a local network of care and social inclusion, with the participation of the communities.
REAR SIDE CONSPICUITY OF HEAVY GOOD VEHICLES BASED ON LIGHTING COMPONENTS
Authors: Yahya Siti Aishah , Izati Rasli Nur Baitul , Ramli Nor Azam , Shith Syabiha 
Published: October 2020

In Malaysia, accidents that involve collisions with rigid and articulated trucks are mainly related to the conspicuity issue i.e. the issue of the conspicuity of the lighting components on heavy goods vehicles (HGVs). Thus, visibility and conspicuity must be improved because such an improvement can help drivers encounter safety measures on the psychological phenomenon. Conspicuity is the ability of a vehicle to be noticed without observers intentionally searching for it. In Malaysia, HGVs must be equipped with lighting components for improved visibility. The study aims to analyse the percentages of lighting components that comply with the MS ISO 303:2004. This research is conducted at Jawi Toll Plaza, Nibong Tebal, Pulau Pinang from 9:00 a.m. to 5:00 p.m. Results show that 93% of two-axle box trucks have installed rear lighting components that adhere to the standard. Meanwhile, other categories are between 38% and 91%. In conclusion, even though Heavy Goods Vehicles recorded as having high compliance levels of the rear lighting components, the accident still occurred. The types of crashes are based on the inadequate visibility involved when the moving vehicles are approaching the rear or sides of slow-moving or stationary vehicles at night.
Microbiological patterns of endophthalmitis in a tertiary level hospital of Kathmandu, Nepal
Authors: Shrestha Smita , Manandhar Anu 
Published: October 2020

Introduction: Endophthalmitis is a serious ocular infection that can result in blindness and therefore is a major ophthalmic concern. The study was conducted to find out the microbial etiology in clinically diagnosed cases of endophthalmitis and to determine the antibacterial susceptibilities of bacterial isolates in vitro.
Materials and methods: A retrospective analysis was carried out of all patients presenting between 15th January 2012 to 15th January 2013 with clinically diagnosed Endophthalmitis at Tilganga Institute of Ophthalmology (TIO). Intraocular specimens (aqueous or vitreous fluids) were collected from 102 patients. Along with intraocular aspirates, blood and urine specimens, chest X-ray from endogenous endophthalmitis and corneal scrapes from corneal ulcer leading to endophthalmitis were also collected. The intraocular specimens were then subjected to microbiological evaluation. Antibiotic susceptibility of isolates were determined for different ocular antibiotics using the Kirby-Bauer disk-diffusion test.
Results: Samples from 102 patients diagnosed with endophthalmitis underwent microbiological analysis, of which culture positive 34(33.33%). Out of 34, 29 (85.29%) had bacterial growth and the remaining 5 (14.70%) had fungal growth. Most of them (40.8%) were secondary to cataract surgery(postoperative). A total of 29 bacterial culture reports, 72.41% were gram-positive and 27.58% were gram-negative. Streptococcus pneumoniae (37.93%) was the most frequently isolated organism. The antimicrobial sensitivity for isolates was as follows: Ofloxacin - 86.2%, Chloramphenicol - 82.75%,Cefazolin- 82.7%, Gentamicin - 75.8%, Ceftazidime - 58.6%, Amikacin - 55.17% and Vancomycin - 51.7%.
Conclusion: The data highlights low culture positivity and a predominance of gram positive bacteria as the major causes of infectious endophthalmitis, usually following cataract surgery. The most common isolate was Streptococcus pneumoniae. Ofloxacin and Chloramphenicol demonstrated greatest efficacy against these bacterial isolates.
Lektura szkolna ucznia z ASD. Na przykładzie W 80 dni dookoła świata Jules’a Verne’a
Authors: Balcerek Helena 
Published: October 2020

The article discusses observations pertaining to one of the basic aims/objectives of education, namely: reception and analysis of a text read by students with ASD (Autism Spectrum Disorder) at the 2nd stage of their education, as well as the form of abridgement of the text (based on the example of Jules Verne’s Around the World in Eighty Days) to suit the needs and capabilities of special-needs students. The conclusions presented herein result from pedagogical observations conducted during many years of a Polish-language teacher’s work focused on students with ASD in one of Warsaw’s elementary schools. They point to the necessity of individual facilitation of the entire process of reception, analysis, and interpretation of the text read in order to meet the needs and capabilities of a particular student-reader. Selection of suitable text and the abridgement thereof to the level of a child with developmental disorder classified as ASD, must take into account the preceding diagnosis and special educational needs mentioned in a psychological and pedagogical counselling centre’s medical opinion.
Повсякденне життя Києва доби Гетьманату П. Скоропадського за спогадами О. Гольденвейзера
Authors: Герасимов Тимофій 
Published: October 2020

The purpose of the article is to cover certain aspects of everyday life in Kyiv during the period of Hetman P. Skoropadskyi based on the memoirs of O. Goldenweiser – a well-known lawyer and public figure of the time. The methodology of the research is based on the fundamental principles of scientific knowledge of dialectics and determinism and also scientific – historicism and objectivity. Anthropological, systemic and historical-situational approaches were used to reveal the topic, as well as general scientific (general methods of analysis and synthesis, descriptive-narrative, induction and deduction), special and interdisciplinary methods of scientific research (historical-comparative, historical-typological). Scientific novelty of the work lies in the critical analysis of O. Goldenweiser's memoirs as an important historical source for the study of Kyiv everyday life of Ukrajinsjka Derzhava in 1918. Conclusions. O. Goldenweiser's memoirs contain a lot of cognitive and meaningful material about the everyday history of Kyiv in the period of the study. They repeatedly mention the huge impact on the life of the city of the military contingent from Germany and Austria-Hungary, which the most of kyivans considered as occupation. Throughout almost the entire period of P. Skoropadsky's rule (April – October 1918) Kyiv had a reputation as a safe city for the presence of foreign people, and it was very attractive to those former subjects of the Russian Empire who ran away from Bolshevik terror. As a result, the capital of the Ukrajinsjka Derzhava was literally suffocating from overcrowding – it was almost impossible to find a free apartment at that time. Under such conditions, the socio-economic and socio-cultural aspects of urban everyday life revived sharply. This, for example, found expression in the trade sphere, in particular in its "dark side" – the unprecedented growth of speculation – and in the overcrowding of local cultural and entertainment establishments.
Рейд загону ім. І. Богуна з Волині на Холмщину (травень–липень 1944 р.)
Authors: Бігун Ігор 
Published: October 2020

The purpose of the article is to study the raid of the UPA Ivan Bogun Detachment from Volhynia to Kholmshchyna (Сhełm Land) and back. The research methodology is based on the use of general scientific methods (analysis, synthesis, abstraction and generalization) combined with the principles of historicism, objectivity, system and development. The scientific novelty of the work is that the participation of the Volhynia I. Bogun Detachment from the UPA-North in the Polish-Ukrainian confrontation in the Kholmshchyna, its organizational structure, numerical strength, command staff were determined and the circumstances of crossing the German-Soviet front line were analyzed for the first time in the historiography of the Ukrainian Liberation Movement. Conclusions. I. Bogun Detachment of the UPA-North “Turiv” Group conducted the raid from Volyn Oblast. to Kholm Land in May 1944 to avoid the danger of defeat by regular Wehrmacht units and to wait until it was possible to cross the front line. Once on the territory of the modern Lublin Voivodeship of Poland, O. Gromadiuk‑"Ostrizky's" detachment stationed in villages along the Western Bug River, and also skirmished with German troops. At the end of July 1944, the I. Bogun Detachment broke through the line of the German-Soviet front and returned to Volhynia. During the raid, the insurgent unit consisted of six companies, numbering about 600 soldiers, and in the course of the difficult passage of the front suffered casualties, many troopers straggled or dispersed. Accordingly, after the return, the strength of the detachment was reduced to 320—365 soldiers. In October 1944, the I. Bogun Detachment was reorganized into the Kholm Brigade, which was subordinated to Group Formation № 33 (“Zawichost”) of the UPA-North.
Київський митрополичий хор у ХІХ столітті: реконструкція одягу півчих
Authors: Кривошея Ірина 
Published: October 2020

The purpose of the article is to analyze the known information about the main items of men's wardrobe of the bourgeois in the XIX century and compare it with the data on the choirmen's clothes. To recreate the images of the ceremonial choirmen’s clothes of the Kyiv Metropolitan Choir using written archival and visual (paintings and photos) sources. The research methodology is based on the principles of historicism, consistency, scientific character, and interdisciplinary. The cultural and anthropological approach to the problem involves the study of a person on the basis of the social ties reproduction in a particular location. In this case, the element of everyday life, the clothes of the choirmen are studied through the system of the choirs’ functioning, and their interaction. The following general historical methods were applied: historical-genetic, terminological analysis, and comparative. The use of the problem-chronological method presupposes the systematization of events in chronological sequence, which made it possible to trace the possibilities of using the ceremonial clothes of choirmen for more than one choir, as well as how these processes influenced on economic factors. The scientific novelty of the article consists in the disclosure of new sources and an attempt to reconstruct the ceremonial and everyday clothes of men and boys who were the choirmen of the Metropolitan Choir in the ХІХ century. Conclusions. Thanks to the saved archival sources, as well as samples of art in the ХІХ century, we learn about the style, the material from which the fabric and color were made, as well as the elements of the choirmen’s wardrobe. The comparative analysis allows us to assert that the daily clothes of the choirman did not differ in any way from the clothes of the middle-class bourgeoisie. The main elements of the wardrobe were a cap, an overcoat, a frock coat, trousers, and a sheepskin coat. For its sewing were used inexpensive fabrics such as nankin, cloth, and motley fabric. The difference from the usual and ceremonial clothes of metropolitan choirmen was distinguished by the use of red or blue velvet fabric with gilded trim and tassels. The collected information will help the reader to imagine the appearance of the metropolitan choirmen of the ХІХ century.
Effects of Maternal Exposure to Lamotrigine during Pregnancy on Gonadal Toxicity in Fetus Rats
Authors: Aryan Hoda , Movassaghi Shabnam , Ghasemi Amir , Darabi Roksana 
Published: October 2020

Background: Lamotrigine is one of the newest antiepileptic drugs that is used as one of the most common treatments in pregnancy. Since the investigation of the teratogenic effects of lamotrigine is very limited and there is no report of its teratogenic effects on fetal gonads, we aimed to investigate the teratogenic effects of lamotrigine on embryonic gonads. Materials and Methods: This study was performed on nine female Wistar female rats (8 weeks, weighing 180-200 mg). At first, the animals were inspected regularly by the preparation of vaginal smear and in the estrus phase in separate cages of mating, and after observing the vaginal plaque, were randomly divided into three groups (n=3). Control group did not receive any treatment. In the lamotrigine group (20mg/kg), and the vehicle group (same volume of normal saline) were injected intraperitoneally from days 8 to 13 of pregnancy. On day 20, animals were anesthetized by sodium pentobarbital (40 mg/kg), and embryos were extracted through laparotomy. First, fetuses were weighed, and their height (crown-rump length) was measured. Then the gonads of the fetuses were removed and, stained with H & E, and examined by optical microscope. Results: Our results showed that in the lamotrigine group, the number of seminiferous tubules and Sertoli cells in the male embryos and the number of oocytes in the female embryos decreased significantly compared to the control and vehicle groups (P≤0.05). Conclusion: The results of this study showed that treatment with 20 mg/kg lamotrigine in mothers during pregnancy could cause damage to fetal gonads. [GMJ.2020;9:e1557]