bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experience in managing psoriasis patients receiving targeted therapy during the COVID-19 pandemic
Authors: Potekaev N. N. , Zhukova O. V. , Artemyeva S. I. , Ostretsova M. N. 
Published: November 2020

Introduction. With the onset of the COVID-19 pandemic the dermatological manifestations of the infection are widely discussed along with the correct management tactics for patients with severe chronic dermatoses, primarily those on immunosuppressive therapy. Immunocompromised patients are overly vulnerable to infections, which is especially important in the context of the pandemic. The article provides up-to-date literature information regarding the general risks of infection in patients receiving systemic immunomodulatory agents for the treatment of psoriasis, as well as evidence based treatment recommendations, including the example of our own clinical experience of using targeted therapy during the COVID-19 pandemic.Purpose of the study. The aim of the study was to analyze the therapeutic efficacy and safety of the systemic immunomodulatory drugs therapy in the context of the global COVID-19 pandemic.Materials and methods. The study included 142 patients with psoriasis receiving GEBD and small molecules therapy at the Department of Anti-Cytokine Therapy and Efferent Methods of Treatment of MNPCDK DZM. All patients were examined to determine their level of IgM and IgG antibodies to the SARS-CoV-2 virus strain in the blood serum. All patients continued to receive therapy according to their individual dosing regimen. The study was conducted at a time of high morbidity in the city of Moscow.Results. The overall morbidity among the studied patients was 13.4% of which the majority were patients with an asymptomatic course of the disease. It should be noted that there was a low incidence rate among patients receiving therapy with IL-17 inhibitors (secukinumab, netakimab).Conclusion. Our study confirms worldwide records that there is no evidence of an increased risk of COVID-19 among patients receiving targeted therapy for psoriasis. In our opinion, the discuntinuation of the current treatment can lead to unjustified risks, such as a relapse of psoriasis, including with severe manifestations and subsequent possible ineffectiveness when resuming therapy.Potentially, the termination of therapy that suppresses the production of proinflammatory cytokines will lead to an increase in the “cytokine storm” and a worsening of the course of viral infection when it occurs.
Сapabilitу of 24-hour esophageal pH-impedance monitoring in the diagnosis of GERD-associated laryngeal diseases
Authors: Starostina S. V. , Makhov V. M. , Storonova O. A. , Bolshakov A. V. , Kuprina I. V. , Trukhmanov A. S. , Ivashkin V. T. 
Published: November 2020

Extraesophageal manifestations of gastroesophageal reflux disease (GERD), despite the improvement of methods of diagnosis and treatment of patients with this pathology, still remain an urgent problem of medicine and cause increased attention of clinicians and researchers. In some cases, patients with GERD do not present typical complaints of heartburn, regurgitation; the disease may manifest extraesophageal manifestations, such as chronic cough, hoarseness, reflux laryngitis, and others caused by the presence of laryngopharyngeal reflux (LFR) – inflammation of the mucous membrane of the upper digestive and respiratory tracts with possible morphological changes associated with direct and indirect (reflex) exposure to gastroduodenal reflux. The occurrence of LFR is possible due to a violation of the motor function of the esophagus and insufficiency of the upper esophageal sphincter, as well as a decrease in the tone of the pharyngeal muscles. The most accessible methods of diagnosis of LFR are registration of complaints according to the questionnaire “index of reflux symptoms”, assessment of the clinical and functional state of the larynx using a visually analog “scale of reflux signs”. A positive response to the empirical use of proton pump inhibitors in combination with procinetics and determination of pepsin content in saliva can also be alternative diagnostic methods. To date, 24-hour pH-impedance monitoring is a method that allows the most accurate diagnosis of all types of reflux, regardless of the pH value, to verify high reflux in combination with its physical properties, as well as to estimate the time of chemical and volumetric esophageal clearance. In addition to performing esophagogastroduodenoscopy, the use of this method is indicated in patients with suspected extraesophageal manifestations of GERD. The article presents clinical examples of patients with extraesophageal manifestations of GERD, describes the possibilities of 24-hour pH-impedance monitoring of the esophagus in the diagnosis of LFR and reflux-associated diseases of the larynx.
Modified classification of infralabyrinthie cholesteatoma and scale of cholesteatoma extention
Authors: Diab K. M. , Panina O. S. , Pashchinina O. A. 
Published: November 2020

Introduction. Petrous temporal bone (PTB) cholesteatoma is an epidermal cyst, which is the result of uncontrolled growth of keratinizing squamous epithelium in the petrous part of the temporal bone. Cholesteatoma is classified into congenital, acquired, and iatrogenic.Objective. To discuss the classification of infralabyrinthine petrous bone cholesteatoma (PBC), add modified classificationand to propose adequate differential surgical management.Methods. The setting was a National Medical Scientific Center of Otorhinolaryngology FMBA (Russia). The data of 14 patients who underwent surgery for different variations of infralabyrinthine PBC from 2017 till 2020 were analyzed and included into the study (with respect to localization type of the approach used, complications, recurrences and outcome). The follow-up period ranged from 6 to 34 months with a median of 18 months.Results. Based on preoperative CT scans and intraoperative findings a Scale of Cholesteatoma extension CLIF(APO) and Modified classification of infralabyrinthine cholesteatoma (in relation to mastoid segment of the facial nerve) are proposed. The scale includes the main anatomical structures of the temporal bone and the adjacent parts of the occipital and sphenoid bones, which may be involved in the cholesteatoma process: cochlea, vestibule and semicircular canals, internal auditory canal, jugular foramen, bony chanal of the internal carotid artery, petrous apex, occipital condyle. Based on the modified classification and scale we present an algorithm for decision making and surgical approach choosing.Conclusion. The implementation of the Scale of Cholesteatoma Extension in Otology and Radiology practice will allow to preoperatively diagnose the extension of PBC, unify the data of the localization of cholesteatoma; allows standardization in reporting and continuity at all stages of treatment. The modified classification proposed by us in this article facilitate the algorithm for selecting the type of surgical approach and determine whether to perform less aggressive combined microscopic approaches with endoscopic control.
Evaluation of the In Vivo Acute Toxicity and In Vitro Hemolytic and Immunomodulatory Activities of the Moringa oleifera Flower Trypsin Inhibitor (MoFTI)
Authors: de Siqueira Patriota Leydianne Leite , do Nascimento Santos Dayane Kelly Dias , da Silva Barros Bárbara Rafaela , de Souza Aguiar Lethícia Maria , Silva Yasmym Araújo , dos Santos Angela Caroline Lima Amorim , Gama e Silva Mariana , Barroso Coelho Luana Cassandra Breitenbach , Paiva Patrícia Maria Guedes , Pontual Emmanuel Viana , de Melo Cristiane Moutinho Lagos , Mendes Rosemairy Luciane , Napoleáo Thiago Henrique 
Published: November 2020

Background:Protease inhibitors have been isolated from plants and present several biological activities, including immunomodulatory action.Objective:This work aimed to evaluate a Moringa oleifera flower trypsin inhibitor (MoFTI) for acute toxicity in mice, hemolytic activity on mice erythrocytes and immunomodulatory effects on mice splenocytes.Methods:The acute toxicity was evaluated using Swiss female mice that received a single dose of the vehicle control or MoFTI (300 mg/kg, i.p.). Behavioral alterations were observed 15–240 min after administration, and survival, weight gain, and water and food consumption were analyzed daily. Organ weights and hematological parameters were analyzed after 14 days. Hemolytic activity of MoFTI was tested using Swiss female mice erythrocytes. Splenocytes obtained from BALB/c mice were cultured in the absence or presence of MoFTI for the evaluation of cell viability and proliferation. Mitochondrial membrane potential (Δψm) and reactive oxygen species (ROS) levels were also determined. Furthermore, the culture supernatants were analyzed for the presence of cytokines and nitric oxide (NO).Results:MoFTI did not cause death or any adverse effects on the mice except for abdominal contortions at 15–30 min after administration. MoFTI did not exhibit a significant hemolytic effect. In addition, MoFTI did not induce apoptosis or necrosis in splenocytes and had no effect on cell proliferation. Increases in cytosolic and mitochondrial ROS release, as well as Δψm reduction, were observed in MoFTI-treated cells. MoFTI was observed to induce TNF-α, IFN-γ, IL-6, IL-10, and NO release.Conclusion:These results contribute to the ongoing evaluation of the antitumor potential of MoFTI and its effects on other immunological targets.
Dualidade e Unidade de Jurisdição no Brasil
Authors: De Aragão J.Guilherme 
Published: November 2020

A Constituição de 24 de fevereiro de 1891, instituindo o regime de dualidade de justiça — Justiça Estadual e Justiça Federal reservou lugar próprio para as questões antes confiadas ao contencioso administrativo (art. 60 da Constituição de 1891).
Êsse lugar foi delimitado pela Lei n.° 221, de 20 de novembro de 1894, relativa à organização da Justiça Federal. Em seu Titulo II,o citado diploma legal conferiu aos juizes e tribunais federais, competência para conhecerem de atos ou decisões das autoridades administrativas, lesivos de direitos individuais, e julgarem as questões daí decorrentes.
O Estado e os Serviços Públicos
Authors: Nogueira Alcântara 
Published: November 2020

Através dos séculos, para explicar a formação e o desenvolvimento doEstado, bem como determinar seus elementos, diversas tem sido as teoriasformuladas pelos filósofos do Direito. No que concerne a esses elementosconstitutivos do Estado, encontra-se em plano destacado a soberania que, paiaum grande número de juristas, antigos e modernos e o principal.
Le don des formes
Authors: Barilier Étienne 
Published: November 2020

Enseigner la littérature, c’est simplement et véritablement la lire, donc en accueillir, en recueillir les richesses ; découvrir et décrire ses constellations, suivre les contours signifiants de ses formes, afin que les étudiants, et nous avec eux, s’en trouvent enrichis, formés.
Educational Neglect and Child Protection in Ontario
Authors: Harris Joanna 
Published: November 2020

Education is a basic human right, critical to the social and economic well-being of children and youth. It is so fundamental to a child’s well-being that Ontario courts have repeatedly recognized that educational neglect is a stand-alone child protection concern justifying state intervention. Courts in Ontario acknowledge that educational neglect is also a significant indicator of greater neglect within the child’s family. Education law, and child protection law, are remedies that should both be utilized to remedy educational neglect in a child’s life.
Children involved with child welfare system are vulnerable and often fail to achieve basic educational goals as a result of preexisting neglect but also as a result of the system itself. Greater collaboration is needed between educators, social workers, and responsible Ministries to ensure that vulnerable children’s educational needs are met.
Perbandingan Tingkat Pengembalian Kredit pada Lembaga Perkreditan Desa (LPD) yang dicirikan Kecamatan Mayoritas Penduduk Bekerja di Sektor Pertanian dengan Jasa di Kabupaten Gianyar.
Authors: Agustini Nita , Susrusa Ketut Budi , Arisena Makse Korri 
Published: November 2020

Pembentukan Lembaga Perkreditan Desa (LPD) dalam membantu masyarakat desa untuk meningkatkan usaha ekonomi diantaranya adalah melalui LPD Kecamatan Payangan dan LPD Kecamatan Gianyar, Gianyar, Bali. LPD senantiasa mengutamakan dan memperhatikan aspek efisiensi serta produktivitas, salah satunya adalah dengan cara penyaluran dana (kredit). Penelitian ini dilakukan untuk mengetahui distribusi pinjaman berdasarkan sektor dari segi jumlah nasabah dan besarnya pinjaman dan perbandingan tingkat pengembalian kredit pada LPD di Kecamatan Payangan dan LPD di kecamatan Gianyar. Teknik penentuan sampel dalam penelitian ini dilakukan secara sensus, dan diperoleh 33 LPD di Kecamatan Payangan dan 39 LPD di Kecamatan Gianyar. Teknik analisis yang digunakan adalah analisis Uji Mann – Whitney (U-Test). Hasil penelitian menunjukkan bahwa tidak ada perbedaan tingkat pengembalian kredit antara LPD di Kecamatan Payangan yang berbasis pada sektor pertanian dengan LPD di Kecamatan Gianyar yang berbasis pada sektor jasa. Melalui penelitian ini, LPD yang tingkat pengembalian kreditnya masih di bawah 80% sebaiknya lebih memperketat seleksi pemberian kreditnya agar tidak menjadi kredit bermasalah sehingga dapat memperoleh keuntungan dari kredit yang disalurkan oleh LPD.
Konseling Gestalt untuk Menyelesaikan Unfinished Business
Authors: Paramita Rizki Wira 
Published: November 2020

Subjek merupakan anak kedua dari tiga bersaudara, laki-laki, dan berusia 16 tahun. Subjek mengeluhkan memiliki hubungan yang kurang baik dengan ayah dan kakak yang membuatnya merasa tidak senang dan tidak nyaman saat berada di rumah. Metode asesmen menggunakan wawancara, observasi, dan tes psikologi. Hasil asesmen subjek didiagnosis memiliki masalah dengan family interaction yang disebabkan unfinishedbusiness. Intervensi psikologi menggunakan konseling gestalt yang bertujuan meningkatkan family interaction dengan menyelesaikan unfinished business. Hasil intervensi menunjukkan subjek mampu menyelesaikan unfinished business dan memiliki interaksi dalam keluarga yang lebih baik dari sebelumnya. Konseling, gestalt, unfinished business
Analysis of Hospital Information System Implementation Using the Human-Organization-Technology (HOT) Fit Method: A Case Study Hospital in Indonesia
Authors: Puspita Silvanus Chakra , Supriyantoro . , Hasyim . 
Published: November 2020

Background and purpose: The implementation of Hospital Information System (HIS) is important to achieve strategic objectives based on quality services. For this reason, an evaluation is needed to find out how the benefits of HIS in the hospital work unit. This study uses the evaluation framework of Human, Organization, Technology (HOT) Fit which was introduced by Yusof in 2008.
Methods: This research method was carried out using a mixed method approach where the quantitative approach was processed by using Partial Least Square. The sample was obtained through proportionate stratified random sampling, namely 201 respondents who were employees of HIS users in MHJS hospital. The research instrument used a questionnaire and was measured using a Likert scale
Results: Based on the results of the t-statistic test, there is a misfit which appears in the insignificant direct effect between service quality on user satisfaction (p-value 0.062), service quality on system use (p-value 0.063), organizational structure for system use (p-value 0.492) and user satisfaction with system usefulness (p-value 0.188).
Conclusions: It is necessary to improve the service quality because does not significantly influence user satisfaction and system use. System quality provides a dominant influence on user satisfaction, the use of systems and organizational structures so that management plays a very important role in the implementation of HIS in MHJS hospital.
Venous Branch Occlusion: What If It Was Not Just Hypertension!
Authors: Dahi Sidi , Salem Joumany Brahim , Khamaily Mehdi , Tarib Imane , Zerrouk Rachid , Mouzari Yassine , El Asri Fouad , Reda Karim , Oubaaz Abdelabarre 
Published: November 2020

We report the case of a hypertensive patient who has macular edema, secondary to retinal vein occlusions, revealing pigmentary glaucoma.
54-year-old man had a visual impairment in the left eye. In connection with an retinal vein occlusion; the interview reported hypertension and diabetes, The diagnosis of occlusion of the old retinal vein branch associated with pigmentary glaucoma in a strong myopic is made. Before hypertension, the search for glaucomatous ocular hypertonia must be systematic because it is a particular cause of retinal vein occlusions Related to papillary excavation.
Neutropenia is Less Frequent in Patients than in General Population: A Benign (Ethnic) Neutropenia Study
Authors: Denic Srdjan , Shaban Sami , Narchi Hassib , Souid Abdul-Kader 
Published: November 2020

Background: Benign (ethnic) neutropenia (BN) is an inherited condition, common in many parts of the world, and often undiagnosed. It should be differentiated from other types of neutropenia which increase the risk of infections.
Objective: We aimed to ascertain the frequency of neutropenia in patients from a population (citizens of the United Arab Emirates) with a known high frequency of BN (10.7%) to assess how often clinicians might be compelled to differentiate benign neutropenia from other types of neutropenia.
Methodology: Study subjects were 27,392 Emirati inpatients and outpatients of all ages in a general hospital. They had 55,935 absolute neutrophil counts (ANC). Patients were defined to have neutropenia if the ANC was <1.5x109/L. The frequency of neutropenia was analyzed against several relevant variables.
Results: Among patients who had one test, the overall frequency of neutropenia (5.3%) was half that in a healthy population (10.7%) in earlier study (p < 0.0001). The prevalence of neutropenia was lower in hospitalized (3.5%, 132/3,769) than in non-hospitalized (9.2%, 510/5,570) patients (p<0.0001), where it was similar (p=0.13) to that in the general population (10.7%, 110/1032). While none of the 282 pregnant women at the time of delivery had neutropenia, it was most common among pediatric outpatients (15.1%, 75/497). Neutropenia was more frequent in patients who had more ANC determinations: one test, 5.3%; two tests, 7.8%; three and more tests, 12.4% (p<0.00001).
Hypertension Associated with Coarction (COA) of the Aorta. Case Report from Clinical Experience in Paediatric
Authors: Mohamednour Eilaf , Wolffsohn Kirsten 
Published: November 2020

Coartion of the aorta is a birth defect, in which aorta become narrower than usual and this narrowness differ in the amount from one case to another. Occurring more frequently in boys than girls and the risk increase with family history having, bicuspid aortic valve and in Turner syndrome.
It can present with different clinical presentation depending on the severity of the narrowness; weak or no pulse in the feet and blood pressure in the arm much higher than in the legs. The aim of this case report is to emphasize special attention to coartion of aorta as cause of systemic Hypertension, delineate the difference diagnostic approach for systemic hypertension in children and adult and stress the important of doing proper clinical examination of cardiovascular examination and checking the blood pressure even in young children. Such case will help us pay attention to possibility of COA in children with hypertension.
Unexplained Increase in Death Rate during COVID19 Pandemic Mistakenly Attributed to Malaria
Authors: Ali Ibrahim Abdelrhim , Abdeldafia Alaaeldeen Mohammed Ahmed , Elmalik Abrar Bakry , Elawad Mohamed Eltayieb 
Published: November 2020

Background: Since the emergence of COVID-19 pandemic, the world has faced many challenges. In Sudan, Gizera state has shown mysterious symptoms to the residents of a village and has been diagnosed with malaria.
Aim: The study was aimed to disprove the diagnosis of malaria, and to find another more convincing explanation that fits with the general features of the disease.
Method: A descriptive cross-sectional study was conducted using an electronic questionnaire designed by Google form.
Result: The respondents was 402, the distribution of males and females was 51.7% and 48.3%, respectively. 83% were suffered the symptoms in May and June. The most common symptoms were headache, fever, fatigue and joint pain, back pain, sore throat and anosmia, at 60.7%, 49.8%, 47.3%, 33.3%, 37.3%, and 23.3%, respectively. 61.4% seeked health care, 99.9% performed peripheral blood film for malaria and 83% were positive. 77% of those with positive result, 72% of those with negative results, 62% of those who did not seek health care suffered similar symptoms, mainly headache. Also, anosmia is 30%, and 25% for those who have seeked and have not seeked health care, respectively. The recovery period was less than a week in 49% of those with positive results, 57% of those with negative results, and 63% of those who did not seek health care. It was more than two weeks in 9%, 12%, and 4% in the positive, negative, and uncaring, respectively. 56.5% did not notice the mosquitoes in that period, 31% and 11.7% noticed that and did not know, respectively.
Conclusion: The most likely diagnosis of these mysterious symptoms is COVID-19.
Examining the Relationships between Energy Use, Fossil Fuel Consumption, Carbon Dioxide Emissions, and Economic Growth in Southeast Asia
Authors: NGUYEN Anh Tru 
Published: November 2020

This article examines the relationships between energy use, fossil fuel consumption, CO2 emissions, and economic growth in three developing countries in Southeast Asia between 1988 and 2017. We found that the GDP per capita positively affects per capita CO2 emissions, and that it has a positive relationship with per capita energy use. Additionally, we found that GDP per capita is negatively affected by fossil fuel consumption, whereas it is positively affected by per capita CO2 emissions. Moreover, results show directional relationships running from per capita CO2 emissions to GDP per capita, from GDP per capita to per capita energy use, from GDP per capita to fossil fuel consumption, and from GDP per capita to per capita CO2 emissions. We found cointegration among the variables at the 1% critical value and two levels of cointegration among variables at the 5% critical value. Finally, we recommend policies to boost economic growth, reduce CO2 emissions, and achieve sustainable development in Southeast Asia.
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Análisis de los efectos de la cronificación en usuarios internados en una institución psiquiátrica monovalente
Authors: Zumarraga Florencia 
Published: November 2020

El trabajo propone avanzar en la caracterización de los efectos de cronificación vislumbrados en usuarios internados en una institución psiquiátrica monovalente de la provincia de Buenos Aires. Esta producción nace a partir de los interrogantes y observaciones que han surgido en el marco del proyecto de voluntariado universitario “Redes”. La metodología implementada por el equipo consiste en talleres semanales destinados a los usuarios a partir de una oferta amplia de actividades recreativas y artísticas en función de sus intereses. A los fines de este trabajo, se delimitan los mecanismos de control de los manicomios para distinguir los efectos que se evidencian en sus usuarios. Para ello, se recortan indicadores del funcionamiento de dichas instituciones. Luego, se avanza en la descripción de los efectos subjetivantes advertidos en el espacio de taller. Se parte de una mirada crítica del manicomio, teniendo como ejes trasversales la Ley 26.657 y la ética del psicoanálisis.