bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introduction: Early Catholic Orientalism and the Missionary Discovery of Asian Religions
Authors: Pomplun Robert Trent , Rubiés Joan-Pau , Županov Ines G. 
Published: November 2020

Abstract
New encounters in America, Africa, and Asia facilitated the “discovery” of non-Biblical religious traditions that were distinct from the ancient paganism known to Christian humanists and antiquarians from classical sources and patristic literature. Although Hinduism, Buddhism, and Confucianism did not exist as concepts in the early modern period, the three articles in this special issue illustrate the learning process by which a number of influential and pioneering Catholic missionaries came to distinguish these various traditions from each other. We argue that they did not simply “invent” new religions arbitrarily: instead, on the basis of the very broad categories of true religion and idolatry, they engaged in some close interaction and “dialogue”—albeit usually polemical—with local religious elites and their writings, including Eastern Christians. In addition, in the case of the Jesuits in particular, we note that these various engagements were often connected events that influenced each other in important ways, from India to Japan, from Japan to China, and from all these to Tibet.
Experiment and Quantification of Weight: Late-Renaissance and Early Modern Medical, Mineralogical and Chemical Discussions on the Weights of Metals
Authors: Manzo Silvia 
Published: November 2020

Abstract
This paper explores how a set of observations on the weight of lead were interpreted and assessed between the 1540s and the 1630s across three different interconnecting disciplines: medicine, mineralogy and chemistry. The epistemic import of these discussions will be demonstrated by showing: 1) the changing role and articulation of experience and quantification in the investigation of metals; and 2) the notions associated with weight in different disciplinary frameworks. In medicine and mineralogy, weight was not considered as a specific subject of inquiry in itself, but as a “sign” indicating other relevant properties of metals. In contrast, the chemistry tradition was increasingly concerned with the specific investigation of weight as a property of matter, as seen in the debates that took place in the “chemical revolution.” In addition, this study will reveal the versatility, polysemy, and parallel purposes of the recourse to experiential knowledge in different contexts, where the same “facts” operate within different disciplines.
Access to Justice in the Aarhus Convention – Genesis, Legislative History and Overview of the Main Interpretation Dilemmas
Authors: Jendrośka Jerzy 
Published: November 2020

Abstract
The article present the key elements of the access to justice pillar of the Arhus Convention against the background of its legislative history, conceptual approaches and motivations laying behind certain provisions. On this basis, the article identifies and briefly indicates the main interpretation dilemmas regarding specific provisions of paragraphs 1, 2 and 3 of Article 9 as well as those which apply to access to justice pillar as a whole, in particular the interpretation dilemmas regarding the internal relations between these provisions and the role of this pillar in relation to the other pillars, in particular the public participation pillar. The conclusion is that while the structure of Article 9 is quite clear, as a result of the negotiations certain terms or formulations were introduced which not always convey a clear legal norm and therefore require a thorough examination and certain interpretation. In this context a holistic approach is advocated with the aim to see the Convention as certain logical system in which textual (literal) interpretation of the Convention’s provisions is supplemented with – and give priority to – the systemic, purposive and even historical interpretations.
Tax and Legal Instruments of Protection of Ambient Air as Seen in the Example of the Thermal Upgrade Relief
Authors: Swiech-Kujawska Katarzyna 
Published: November 2020

Abstract
Ambient air is one of the most essential natural resources. Its quality directly impacts the health of living organisms. Thus it determines the scale of public spending as a consequence of atmospheric pollution. At the same time, due to the properties of this resource, the problem of its protection has a transnational, global dimension. Therefore, states should undertake and constantly intensify activities the goal of which is to meet not only ambient air quality norms, but also those norms which will allow an effective impact on the improvement of its quality. Instruments and institutions falling under various branches of the law, including the tax law, are used for this purpose.
A thermal upgrade relief was introduced to the Polish tax system at the beginning of 2019. The basis and principles of its application were defined in the personal income tax act. The paper presents substantiated use of tax instruments in the protection of ambient air, the legal basis and principles of application of the discussed tax preference. The conducted analysis gave rise to the formulation of de lege lata and de lege ferenda conclusions.
Evaluating Relationships between Perception-Reaction Times, Emergency Deceleration Rates, and Crash Outcomes using Naturalistic Driving Data
Authors: Wood Jonathan S. , Zhang Shaohu 
Published: November 2020

Perception-reaction time (PRT) and deceleration rate are two key components in geometric design of highways and streets. Combined with a design speed, they determine the minimum required stopping sight distance (SSD). Current American Association of Highway Transportation Officials (AASHTO) SSD guidance is based on 90th percentile PRT and 10th percentile deceleration rate values from experiments completed in the mid-1990s. These experiments lacked real-world distractions, and so forth. Thus, the values from these experiments may not be applicable in real-world scenarios. This research evaluated (1) differences in PRTs and deceleration rates between crash and near-crash events and (2) developed predictive models for PRT and deceleration rate that could be used for roadway design. This was accomplished using (1) genetic matching (with Rosenbaum’s sensitivity analysis) and (2) quantile regression. These methods were applied to the Strategic Highway Research Program 2 (SHRP2) Naturalistic Driving Study (NDS) data. The analysis results indicated that there were differences in PRT and deceleration rates for crash and near-crash events. The specific estimates were that, on average, drivers involved in crash events took 0.487 s longer to react and decelerated at 0.018 g’s (0.58 ft/s2) slower than drivers in equivalent near-crashes. Prediction models were developed for use in roadway design. These models were used to develop tables comparing existing SSD design criteria with SSD criteria based on the results of the predictive models. These predicted values indicated that minimum design SSD values would increase by 10.5–129.2 ft, dependent on the design speed and SSD model used.
The Statistical Fragility of Hamstring Versus Patellar Tendon Autografts for Anterior Cruciate Ligament Reconstruction: A Systematic Review of Comparative Studies
Authors: Ehlers Cooper B. , Curley Andrew J. , Fackler Nathan P. , Minhas Arjun , Chang Edward S. 
Published: November 2020

Background: Evidence-based medicine utilizes data to inform clinical decision making, despite the ability of a small number of outcome reversals to change statistical significance. P values are common measurements of statistical significance that possess inherent flaws. The inclusion of the fragility index (FI) and fragility quotient (FQ) may provide a clearer conveyance of statistical strength. Purpose/Hypothesis: The purpose was to examine the statistical stability of studies comparing hamstring tendon and bone–patellar tendon–bone autografts in primary single-bundle anterior cruciate ligament reconstruction with independent tunnel drilling. We hypothesized that the findings of these studies are vulnerable to a small number of outcome event reversals, often fewer than the number of patients lost to follow-up. Study Design: Systematic review. Methods: Comparative studies and randomized controlled trials (RCTs) published in 10 leading orthopaedic journals between 2000 and 2020 were analyzed. Statistical significance was defined as a P value ≤.05. FI for each outcome was determined by the number of event reversals necessary to alter significance. FQ was calculated by dividing the FI by the respective sample size. Results: Of the 1803 studies screened, 643 met initial search criteria, with 18 comparative studies ultimately included for analysis, 8 of which were RCTs. A total of 114 outcomes were examined. Overall, the mean (interquartile range) FI and FQ were 3.77 (2-4) and 0.040 (0.016-0.055), respectively. The FI was less than the number of patients lost to follow-up for 76.3% of outcomes. Conclusion: Studies examining graft choice for anterior cruciate ligament reconstruction may not be as statistically stable as previously thought. Comparative studies and RCTs are at substantial risk for statistical fragility, with few event reversals required to alter significance. The reversal of <4 outcome events in a treatment group can alter the statistical significance of a given result; this is commonly fewer than the number of patients lost to follow-up. Future comparative study analyses might consider including FI and FQ with P values in their statistical analysis.
Youth mental health competencies in regional general practice
Authors: Smith Oliver , Bergmann Jessica , Schall Ulrich 
Published: November 2020

Objective: General practitioners (GPs) are key health professionals for referrals to mental health specialists. Youth mental health issues are particularly challenging, requiring a competent assessment and understanding of appropriate referral pathways. We surveyed local GPs about their understanding of youth mental health problems and needs to competently look after young patients. Methods: GPs working in the Hunter region were contacted via email, fax and post over a 6-month period in 2019. Results: Seventy-five GPs participated. They reported 577 of 1698 (34%) of young people seen 2 weeks prior to being surveyed presented with a mental health problem. Predominantly, referrals were to private practice psychologists and Headspace. Almost a third (31%) reported having limited understanding of ‘at-risk mental state’ and are ‘not always comfortable’ when facing a young person with a mental health problem. Nearly all (95%) expressed interest in attending specialised training. GPs identified treatment costs, scarce access to psychiatrists and limited patient engagement as the main obstacles to help young people. Conclusions: Effective treatment of a mental health problem relies on early identification. GPs are seeing young people on a regular basis but don’t feel well equipped for this task and are keen to up-skill, which needs to be addressed by targeted training.
Art-making in mental health – a Fijian pilot study
Authors: Ryan Brigid , Fenner Patricia , Chang Odille , Qaloewai Sefanaia , Nabukavou Thelma , Chetty Salochana 
Published: November 2020

Objective: A pilot art-making and mental health recovery project addressed consumer and carer mental health and well-being in Suva, Fiji. Method: Using feedback surveys, the project evaluated initial training, and a 12-month art programme for consumers, carers and staff across several mental health services. Results: First person and stakeholder group reports from the project reflected broad-scale approval for the novel modality and its potential for continued application in keeping with local cultural values. A broad stakeholder base was involved in planning and participation, aligned with the values of inclusive recovery-oriented mental health service approaches. Conclusions: These results suggest that the programme can add value to mental health care being provided for people with a mental illness in Fiji.
Transition to secondary progression in relapsing-onset multiple sclerosis: Definitions and risk factors
Authors: Iaffaldano Pietro , Lucisano Giuseppe , Patti Francesco , Brescia Morra Vincenzo , De Luca Giovanna , Lugaresi Alessandra , Zaffaroni Mauro , Inglese Matilde , Salemi Giuseppe , Cocco Eleonora , Conte Antonella , Ferraro Diana , Galgani Simonetta , Bergamaschi Roberto , Pozzilli Carlo , Salvetti Marco , Lus Giacomo , Rovaris Marco , Maniscalco Giorgia Teresa , Logullo Francesco Ottavio , Paolicelli Damiano , Achille Mariaclara , Marrazzo Giuseppina , Lovato Valeria , Comi Giancarlo , Filippi Massimo , Amato Maria Pia , Trojano Maria ,   on behalf of the Italian MS Register
Published: November 2020

Background: No uniform criteria for a sensitive identification of the transition from relapsing–remitting multiple sclerosis (MS) to secondary-progressive multiple sclerosis (SPMS) are available. Objective: To compare risk factors of SPMS using two definitions: one based on the neurologist judgment (ND) and an objective data-driven algorithm (DDA). Methods: Relapsing-onset MS patients ( n = 19,318) were extracted from the Italian MS Registry. Risk factors for SPMS and for reaching irreversible Expanded Disability Status Scale (EDSS) 6.0, after SP transition, were estimated using multivariable Cox regression models. Results: SPMS identified by the DDA ( n = 2343, 12.1%) were older, more disabled and with a faster progression to severe disability ( p < 0.0001), than those identified by the ND ( n = 3868, 20.0%). In both groups, the most consistent risk factors ( p < 0.05) for SPMS were a multifocal onset, an age at onset >40 years, higher baseline EDSS score and a higher number of relapses; the most consistent protective factor was the disease-modifying therapy (DMT) exposure. DMT exposure during SP did not impact the risk of reaching irreversible EDSS 6.0. Conclusion: A DDA definition of SPMS identifies more aggressive progressive patients. DMT exposure reduces the risk of SPMS conversion, but it does not prevent the disability accumulation after the SP transition.
The prognostic significance of long non-coding RNAs in hepatocellular carcinoma: An updated meta-analysis
Authors: Liu Jie , Wei Yue , Wang Tao , Zhang Zhexiao , Huang Hairong , Wang Chenfei , Li Huawen , Jia Qing , Wu Hongfu , Zou Tangbin 
Published: November 2020

Background: Recently, many studies have demonstrated that long non-coding RNAs (lncRNAs) are abnormally expressed in hepatocellular carcinoma (HCC) and may serve as a potential molecular biomarker to evaluate the prognosis of hepatocellular carcinoma. Therefore, we accomplished a meta-analysis built on current studies to assess the prognostic value of lncRNAs in hepatocellular carcinoma. Methods: The PubMed database was carefully searched to collect all eligible studies until February 20, 2019. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) of the overall survival, relapse-free survival, and progression-free survival were calculated to evaluate the prognostic significance of lncRNAs expression in hepatocellular carcinoma using Stata12.0 software. Heterogeneity, sensitivity analysis, and publication bias were also evaluated. Results: The results showed that the expression level of lncRNAs was significantly correlated with clinical outcomes. Abnormally expressed lncRNAs predicted poor overall survival (HR=2.19, 95% CI: 1.99-2.42, P<0.001; I2=44.7%, P=0.005), relapse-free survival (HR=2.68, 95% CI: 1.74-4.14, P<0.001; I2=0.0%, P=0.763) and progression-free survival of hepatocellular carcinoma patients (HR=2.44, 95% CI: 1.53-3.89, P<0.001; I2=0.0%, P=0.336). Statistical significance was also noted in subgroup meta-analyses that were stratified by follow-up time, cutoff value, and quality score. Moreover, the pooled results indicated that lncRNAs expression was significantly associated with tumor size (HR=1.48, 95% CI: 1.24-1.79), tumor number (HR=1.34, 95% CI: 1.08-1.66), and tumor node metastasis stage (HR=2.10, 95% CI: 1.48-2.99), but not liver cirrhosis and tumor differentiation ( P>0.05). Conclusions: This meta-analysis indicates that lncRNAs are strongly associated with prognosis in hepatocellular carcinoma and may serve as a promising indicator for prognostic evaluation of patients with hepatocellular carcinoma. But larger clinical studies are needed to verify its feasibility.
Endoscopic band ligation compared to thermal therapy for gastric antral vascular ectasia: A systematic review and meta‐analysis
Authors: Chalhoub Jean M. , Umar Jalaluddin , Groudan Kevin , Hamadeh Nour , Desilets David J. , Greeff Yesenia 
Published: November 2020

AbstractBackgroundGastric antral vascular ectasia is an infrequent cause of gastrointestinal‐related blood loss manifesting as iron‐deficiency anemia or overt gastrointestinal bleeding, and is associated with increased healthcare burdens. Endoscopic therapy of gastric antral vascular ectasia most commonly involves endoscopic thermal therapy. Endoscopic band ligation has been studied as an alternative therapy with promising results in gastric antral vascular ectasia.AimsThe primary aim was to compare the efficacy of endoscopic band ligation and endoscopic thermal therapy by argon plasma coagulation for the management of bleeding gastric antral vascular ectasia in terms of the mean post‐procedural transfusion requirements and the mean hemoglobin level change. Secondary outcomes included a comparison of the number of sessions needed for cessation of bleeding, the change in transfusion requirements, and the adverse events rate.MethodsPubMed, Medline, SCOPUS, Google Scholar, and the Cochrane Controlled Trials Register were reviewed. Randomized controlled clinical trials and retrospective studies comparing endoscopic band ligation and endoscopic thermal therapy in bleeding gastric antral vascular ectasia, with a follow‐up period of at least 6 months, were included. Statistical analysis was done using Review Manager.ResultsOur search yielded 516 papers. After removing duplicates and studies not fitting the criteria of selection, five studies including 207 patients were selected for analysis. Over a follow‐up period of at least 6 months, patients treated with endoscopic band ligation had significantly lower post‐procedural transfusion requirements (MD −2.10; 95% confidence interval (−2.42 to −1.77)) and a significantly higher change in the mean hemoglobin with endoscopic band ligation versus endoscopic thermal therapy (MD 0.92; 95% confidence interval [0.39–1.45]). Endoscopic band ligation led to a fewer number of required sessions (MD −1.15; 95% confidence interval [−2.30 to −0.01]) and a more pronounced change in transfusion requirements (MD −3.26; 95% confidence interval [−4.84 to −1.68]). There was no difference in adverse events.ConclusionResults should be interpreted cautiously due to the limited literature concerning the management of gastric antral vascular ectasia. Compared to endoscopic thermal therapy, endoscopic band ligation for the management of bleeding gastric antral vascular ectasia led to significantly lower transfusion requirements, showed a trend toward more remarkable post‐procedural hemoglobin elevation, and a fewer number of procedures. Endoscopic band ligation may improve outcomes and lead to decreased healthcare burden and costs.
Feasibility and Assessment of a Machine Learning-Based Predictive Model of Outcome After Lumbar Decompression Surgery
Authors: André Arthur , Peyrou Bruno , Carpentier Alexandre , Vignaux Jean-Jacques 
Published: November 2020

Study design: Retrospective study at a unique center. Objective: The aim of this study is twofold, to develop a virtual patients model for lumbar decompression surgery and to evaluate the precision of an artificial neural network (ANN) model designed to accurately predict the clinical outcomes of lumbar decompression surgery. Methods: We performed a retrospective study of complete Electronic Health Records (EHR) to identify potential unfavorable criteria for spine surgery (predictors). A cohort of synthetics EHR was created to classify patients by surgical success (green zone) or partial failure (orange zone) using an Artificial Neural Network which screens all the available predictors. Results: In the actual cohort, we included 60 patients, with complete EHR allowing efficient analysis, 26 patients were in the orange zone (43.4%) and 34 were in the green zone (56.6%). The average positive criteria amount for actual patients was 8.62 for the green zone (SD+/- 3.09) and 10.92 for the orange zone (SD 3.38). The classifier (a neural network) was trained using 10,000 virtual patients and 2000 virtual patients were used for test purposes. The 12,000 virtual patients were generated from the 60 EHR, of which half were in the green zone and half in the orange zone. The model showed an accuracy of 72% and a ROC score of 0.78. The sensitivity was 0.885 and the specificity 0.59. Conclusion: Our method can be used to predict a favorable patient to have lumbar decompression surgery. However, there is still a need to further develop its ability to analyze patients in the “failure of treatment” zone to offer precise management of patient health before spinal surgery.
Open-Globe Injury With Intraocular Foreign Body
Authors: Vingopoulos Filippos , Wang Yvonne , Grob Seanna , Li Chloe Yang Ling , Eliott Dean , Kim Leo A. , Vavvas Demetrios G. , Miller John B. 
Published: November 2020

Purpose: To investigate characteristics of Open Globe Injuries (OGI) that presented with Intra-Ocular Foreign Body (IOFB), along with their long-term visual outcomes and complications. Methods: Retrospective interventional consecutive case series of OGIs with IOFBs that presented at Massachusetts Eye and Ear from 2010 to 2015. Data collected included time from injury to OGI repair, location of IOFB, retinal detachment (RD) rate, presenting and final visual acuity and subsequent surgeries. Results: Fifty-seven consecutive cases of OGIs with IOFBs were included. Mean follow-up was 28 months and median time from injury to OGI repair was 0 days. Overall, 38/57 (66.7%) eyes achieved final vision of 20/40 or better and 43/57 (75.4%) 20/150 or better. Thirty-three cases had IOFBs in the anterior segment only, 24 cases had posterior segment involvement. Thirty percent of cases (17/57) were complicated by an RD, 58.3% (14/24) in the posterior versus 9.1% (3/33) in the anterior IOFB group ( P = .01). There were no cases of endophthalmitis. Posterior IOFB and higher zone of injury were risk factors for RD both at presentation (both P < .001) and post-primary repair (both P < .001). Posterior IOFB was associated with higher vitrectomy rates both at presentation ( P < .001) and post-primary repair ( P = .002) and worse long-term visual outcome ( P = .01). Conclusions: OGIs with IOFB involving the posterior segment are associated with higher complication and re-operation rates and worse visual prognosis compared to those involving the anterior segment only.