bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contribuições das pesquisas sobre tecnologias e formação docente no campo da EJA
Authors: Soek Ana Maria , Haracemiv Sonia Maria , Guérios Ettiène , Silva Larissa Barbosa Luiz Rodrigues da 
Published: March 2020

Este artigo apresenta um mapeamento das contribuições das pesquisas que tratam das especificidades do campo da Educação de Jovens e Adultos (EJA) e que trazem em seu escopo as temáticas de Tecnologias e Formação Docente. A proposta busca identificar os objetos de estudo e os principais conceitos que suscitam as discussões em relação ao tema, bem como os principais teóricos e referências das áreas abordadas. A produção é parte de um estudo bibliográfico numa abordagem qualitativa, a partir do mapeamento das produções no campo da EJA, Tecnologias e Formação Docente, visando identificar os principais conceitos desse campo de estudos como subprojeto da pesquisa Epeja-UFSC, que visa à elaboração de um glossário temático conceitual. Para tanto, foram selecionados dentre os 69 artigos indexados na Base da Capes Periódicos, no período de 2007 a 2017. Analisando-se o material selecionado, foi possível identificar várias relações com outros conceitos correlatos, como por exemplo: formação e profissionalização docente; saberes docentes; formação continuada de professores; práticas pedagógicas; estágios supervisionados e políticas públicas na Educação. Na análise, outros conceitos foram identificados como os referentes à metodologia de pesquisa em educação; às políticas da pós-graduação; à educação matemática; às práticas baseadas em evidência na educação e à representação semiótica. Além da diversidade de temas, foi possível observar também a diversidade e amplitude do referencial teórico adotado nos estudos analisados, conforme as temáticas abordadas.
To clamp or not to clamp?
Authors: Clark Roderick , Fan Stacy , Navaratnam Roshan , Punjani Nahid , Power Nicholas 
Published: March 2020

Introduction: Radical prostatectomy (RP) is the gold-standard surgical treatment for men with clinically localized prostate cancer (PCa). Surgical techniques to minimize intra and post-operative complications are well established, but excessive bleeding during RP continues to be a concern. The objective of our study was to determine whether additional intraoperative temporary occlusion of the internal iliac arteries combined with a penile base tourniquet during open RP improves hemostasis.
Methods: We conducted a retrospective chart review of 23 patients who underwent open RP between Jan 2014 to May 2016. Eight patients underwent open RP with additional clamping of the internal iliac arteries using bulldog vascular clamps combined with a penile base penrose drain tourniquet as temporary prostatic arterial and venous control during dorsal venous complex ligation and neurovascular bundle sparing. Our primary outcome was immediate and post-operative day 1 hemoglobin levels. Our main outcome was analyzed using Students t-test with equal variance.
Results: We stratified participants by clamping type. Fifteen patients underwent no clamping and 8 patients had the combined temporary clamping. Primary analysis of estimated blood loss showed a reduction in average blood loss among individuals with vascular control technique versus usual technique (516 ml and 754 ml respectively, p= 0.021). There were no obvious intraoperative or postoperative complications noted that could have been attributable to the temporary vascular control techniques.
Conclusion: Temporary vascular control with the addition of minor surgical techniques during open RP may improve an objective measure of blood loss immediately after surgery.
An exploration of sociological factors that contribute to physician burnout
Authors: Gray Jennifer 
Published: March 2020

A discussion about mental health and how it relates to the medical profession is incomplete without exploring the concept of burnout. The implications of physician burnout are profound, and it is plaguing the medical community at epidemic rates. Current research focuses on which occupational factors may be contributing to this problem. Other approaches involve investigating the efficacy of building resilience at the individual level as a means of combatting burnout. Examining this issue through a broader lens and considering sociocultural factors that may be influencing how medicine is experienced by those in the field is remarkably untouched in the literature. This article will discuss how several changes in contemporary Canadian society may be underlying factors in physician burnout. The increasing penetrance of the internet into patient-physician interactions, the rise of online review platforms and widespread secularization in a domain that continues to face issues that evidence-based medicine fails to explain will all be addressed. This is merely a preliminary discussion to fortify current initiatives aimed at promoting awareness of and preventing physician burnout.
Increase in Subcellular GSK-3 Clusters in Insulin- and Adrenaline-treated Differentiated Rat Skeletal Muscle Fibres
Authors: Fink Katja , Lobe Prebil Mateja , Vardjan Nina , Jensen Jorgen , Zorec Robert , Kreft Marko 
Published: March 2020

Glycogen synthase kinase 3 (GSK-3) plays an important role in metabolic regulation in skeletal muscles, and both insulin and adrenaline stimulate GKS-3 phosphorylation. The aim of the present study was to study the effect of insulin and adrenaline on GSK-3 localisation in skeletal muscles.We characterized subcellular localization of (GSK-3) signal protein in fully differentiated muscle fibre by immunofluorescence and confocal microscopy. We stimulated muscle fibres with insulin and/or adrenaline. Images were analysed by segmentation of single central optical section of the muscle.We found GSK-3 to be localised in clusters. The number of GSK-3 clusters and their average size were increased after stimulation with insulin and/or adrenaline. Average GSK-3 particle size is linearly related to their quantity.We conclude that subcellular GSK-3 in isolated skeletal muscle fibres is localized in clusters and clustering increased after stimulation with insulin and/or adrenaline.
Single trial estimation of event‐related potential components using spatiotemporal filtering and artificial bee colony optimized Gaussian kernel mixture model
Authors: Ranjbar Mojtaba , Mikaeili Mohammad , Banaraki Anahita Khorami 
Published: March 2020

AbstractSingle trial estimation of event‐related potential (ERP) components is an open research topic in neuroscience. In this article, we have proposed a method to improve the performance of spatiotemporal filtering by decreasing its dependency to prior estimates of ERP components. For this purpose, we have used a mixture of Gaussian kernels instead of a raw prior signal, and the parameters of the Gaussian kernel are estimated using artificial bee colony algorithm. The algorithm starts with one Gaussian kernel, and after optimizing its parameters, another Gaussian kernel is added. This procedure goes on until the stopping criterion is reached. The efficiency of the algorithm is tested for one single uncorrelated component and two correlated components for synthesized electroencephalogram (EEG) signal. Also, the efficiency of the proposed method is presented on real data for extraction of N170 component in real EEG data.
3D Printed Smart Windows for Adaptive Solar Modulations
Authors: Zhou Chengzhi , Li Dan , Tan Yutong , Ke Yujie , Wang Shancheng , Zhou Yang , Liu Guowei , Wu Shaofan , Peng Jinqing , Li Anran , Li Shuzhou , Chan Siew Hua , Magdassi Shlomo , Long Yi 
Published: March 2020

AbstractVanadium dioxide (VO2) based thermochromic smart window is considered as the most promising approach for economizing building energy consumption. However, the high phase transition temperature (τc), low luminous transmission (Tlum), and solar modulation (ΔTsol) impose an invertible challenge for commercialization. Currently, smart window research surprisingly assumes that the sunlight radiates in one direction which is obviously not valid as most regions receive solar radiation at various angles in different seasons. For the first time, solar elevation angle is considered and 3D printing technology is employed to fabricate tilted microstructures for modulating solar transmission dynamically. To maximize energy‐saving performance, the architecture of the structures (tilt, thickness, spacing, and width) and tungsten (W) doped VO2 can be custom‐designed according to the solar elevation angle variation at the midday between seasons and tackle the issue of compromised Tlum and ΔTsol with W‐doping. The energy consumption simulations in different cities prove the efficiency of such dynamic modulation. This first attempt to adaptively regulate the solar modulation by considering the solar elevation angle together with one of the best reported thermochromic properties (τc = 40 °C, Tlum(average) = 40.8%, ΔTsol = 23.3%) may open a new era of real‐world‐scenario smart window research.
Effect of Gate Conductance on Hygroscopic Insulator Organic Field‐Effect Transistors
Authors: Arthur Joshua N. , Chaudhry Mujeeb Ullah , Woodruff Maria A. , Pandey Ajay K. , Yambem Soniya D. 
Published: March 2020

AbstractHygroscopic insulator field‐effect transistors (HIFETs) are a class of low‐voltage‐operation organic transistors that have been successfully demonstrated for biosensing applications through modification of the gate electrode. However, modification of the gate electrode often leads to nonideal transistor characteristics due to changes in its intrinsic electrical properties. This work investigates the effect of gate conductance in HIFETs using poly(3,4‐ethylenedioxythiophene):poly(styrene sulfonate) as a model gate electrode. It is revealed that a reduction in gate conductance results in a reduction in the effective gate voltage and plays an important role in defining HIFET characteristics. Key figures of merit, including ON/OFF ratio, threshold voltage, transconductance, and saturation mobility increase with increasing gate conductance and reach a plateau once sufficient gate conductance is attained. This effect is attributed to a decrease in the effective gate voltage along the gate electrode arising from its resistivity when a gate leakage current is present. These results are widely applicable and serve as design rules for HIFET device optimization.
Triethylene Glycol Substituted Diketopyrrolopyrrole‐ and Isoindigo‐Dye Based Donor–Acceptor Copolymers for Organic Light‐Emitting Electrochemical Cells and Transistors
Authors: Liu Qian , Kanahashi Kaito , Matsuki Keiichiro , Manzhos Sergei , Feron Krishna , Bottle Steven E. , Tanaka Kazuhiro , Nanseki Tomonori , Takenobu Taishi , Tanaka Hisaaki , Sonar Prashant 
Published: March 2020

AbstractTriethylene glycol, a common side chain, is attached to two different dye moieties, diketopyrrolopyrrole (DPP) and isoindigo (II), and their bromo derivative monomers are copolymerized, respectively, with common bisstannyl alkylated bithiophene via Stille coupling. The resulting donor–acceptor low‐bandgap copolymers, namely, PTDPP‐DT and PTII‐DT, are rationally deigned and synthesized conjugated polymeric systems suitable for doping. Both polymers are successfully investigated as single‐component and composite‐system‐based electrochemical transistors and light‐emitting electrochemical cells. A PTDPP‐DT thin film exhibits relatively high electrical conductivity of up to 80 S cm−1 in the electrochemically doped state, whereas PTII‐DT thin film prevents the macroscopic charge transport due to a large‐scale crystalline disorientation. Upon evaluating both polymers as active conjugated materials in light‐emitting electrochemical cells, they both exhibit emission under efficient electron/hole doping conditions.
Neurodevelopmental outcome of prenatally diagnosed boys with 47,XXY (Klinefelter syndrome) and the potential influence of early hormonal therapy
Authors: Samango‐Sprouse Carole A. , Tran Selena L. , Lasutschinkow Patricia C. , Sadeghin Teresa , Powell Sherida , Mitchell Francie L. , Gropman Andrea 
Published: March 2020

AbstractThis cross‐sectional study examined the neurodevelopment of a large, prenatally diagnosed population of boys with 47,XXY; investigated the potentially positive effects of early hormonal therapy (EHT) on language, cognition, and motor in this population; and identified novel at risk biomarkers associated with 47,XXY. Two‐hundred and seventy two evaluations were collected from 148 prenatally diagnosed boys with 47,XXY between 0 and 36 months and separated into one of three groups, depending on visit age: Y1 (0–12 months; n = 100), Y2 (13–24 months; n = 90), and Y3 (25–36 months; n = 82). Those who received EHT (administered by 12 months) were further separated (Y1, n = 37; Y2, n = 34; Y3, n = 30). Neurodevelopmental evaluations consisted of Preschool Language Scales, Early Language Milestone Scale, and Bayley Scales of Infant and Toddler Development and evaluated the effect of EHT on auditory comprehension, expressive communication, receptive language, cognition, and motor. EHT was found to be associated with a positive effect within the first year of life in these domains, as well as in the second and third year of life. Additionally, three novel at‐risk biomarkers were identified in this cohort: feeding difficulties in infancy, positional torticollis, and the need for orthotics. The positive effects of EHT observed in language, cognition, and motor at variable stages within the first 3 years of life provide additional evidence into the possible efficacy of early biological treatment for boys with 47,XXY to address the neurodevelopmental dysfunction.
Long‐term observation of a Japanese mucolipidosis IV patient with a novel homozygous p.F313del variant of MCOLN1
Authors: Hayashi Takaaki , Hosono Katsuhiro , Kubo Akiko , Kurata Kentaro , Katagiri Satoshi , Mizobuchi Kei , Kurai Minehiro , Mamiya Norihito , Kondo Mineo , Tachibana Toshiaki , Saitsu Hirotomo , Ogata Tsutomu , Nakano Tadashi , Hotta Yoshihiro 
Published: March 2020

AbstractMucolipidosis type IV (MLIV) is an autosomal recessively inherited lysosomal storage disorder characterized by progressive psychomotor delay and retinal degeneration that is associated with biallelic variants in the MCOLN1 gene. The gene, which is expressed in late endosomes and lysosomes of various tissue cells, encodes the transient receptor potential channel mucolipin 1 consisting of six transmembrane domains. Here, we described 14‐year follow‐up observation of a 4‐year‐old Japanese male MLIV patient with a novel homozygous in‐frame deletion variant p.(F313del), which was identified by whole‐exome sequencing analysis. Neurological examination revealed progressive psychomotor delay, and atrophy of the corpus callosum and cerebellum was observed on brain magnetic resonance images. Ophthalmologically, corneal clouding has remained unchanged during the follow‐up period, whereas optic nerve pallor and retinal degenerative changes exhibited progressive disease courses. Light‐adapted electroretinography was non‐recordable. Transmission electron microscopy of granulocytes revealed characteristic concentric multiple lamellar structures and an electron‐dense inclusion in lysosomes. The in‐frame deletion variant was located within the second transmembrane domain, which is of putative functional importance for channel properties.
Prevention of pathogen transmission during ultrasound use in the Intensive Care Unit: Recommendations from the College of Intensive Care Medicine Ultrasound Special Interest Group (USIG)
Authors: Costello Cartan , Basseal Jocelyne M , Yang Yang , Anstey James , Yastrebov Konstantin 
Published: March 2020

AbstractICU ultrasonography constitutes important part of modern car patient care. Current standards and practice of infection control and prevention are inadequate. This purpose of this document is to adapt and expand the 2017 Australasian Society for Ultrasound in Medicine (ASUM) and the Australasian College for Infection Prevention Control (ACIPC) guidelines on minimum standards for reprocessing/cleaning of ultrasound transducers to the specifics of intensive care medicine and provide advice to the ICU practitioners and health care administrators. It considers the medical, administrative, financial and practical controversies surrounding implementation, and addresses emerging issues of care for patients with confirmed or suspected Corona Virus Disease 2019 (COVID‐19).
ATPase Domain AFG3L2 Mutations Alter OPA1 Processing and Cause Optic Neuropathy
Authors: Caporali Leonardo , Magri Stefania , Legati Andrea , Del Dotto Valentina , Tagliavini Francesca , Balistreri Francesca , Nasca Alessia , La Morgia Chiara , Carbonelli Michele , Valentino Maria L. , Lamantea Eleonora , Baratta Silvia , Schöls Ludger , Schüle Rebecca , Barboni Piero , Cascavilla Maria L. , Maresca Alessandra , Capristo Mariantonietta , Ardissone Anna , Pareyson Davide , Cammarata Gabriella , Melzi Lisa , Zeviani Massimo , Peverelli Lorenzo , Lamperti Costanza , Marzoli Stefania B. , Fang Mingyan , Synofzik Matthis , Ghezzi Daniele , Carelli Valerio , Taroni Franco 
Published: March 2020

ObjectiveDominant optic atrophy (DOA) is the most common inherited optic neuropathy, with a prevalence of 1:12,000 to 1:25,000. OPA1 mutations are found in 70% of DOA patients, with a significant number remaining undiagnosed.MethodsWe screened 286 index cases presenting optic atrophy, negative for OPA1 mutations, by targeted next generation sequencing or whole exome sequencing. Pathogenicity and molecular mechanisms of the identified variants were studied in yeast and patient‐derived fibroblasts.ResultsTwelve cases (4%) were found to carry novel variants in AFG3L2, a gene that has been associated with autosomal dominant spinocerebellar ataxia 28 (SCA28). Half of cases were familial with a dominant inheritance, whereas the others were sporadic, including de novo mutations. Biallelic mutations were found in 3 probands with severe syndromic optic neuropathy, acting as recessive or phenotype‐modifier variants. All the DOA‐associated AFG3L2 mutations were clustered in the ATPase domain, whereas SCA28‐associated mutations mostly affect the proteolytic domain. The pathogenic role of DOA‐associated AFG3L2 mutations was confirmed in yeast, unraveling a mechanism distinct from that of SCA28‐associated AFG3L2 mutations. Patients' fibroblasts showed abnormal OPA1 processing, with accumulation of the fission‐inducing short forms leading to mitochondrial network fragmentation, not observed in SCA28 patients' cells.InterpretationThis study demonstrates that mutations in AFG3L2 are a relevant cause of optic neuropathy, broadening the spectrum of clinical manifestations and genetic mechanisms associated with AFG3L2 mutations, and underscores the pivotal role of OPA1 and its processing in the pathogenesis of DOA. ANN NEUROL 2020 ANN NEUROL 2020;88:18–32
Mean Oxygen Saturation during Sleep Is Related to Specific Brain Atrophy Pattern
Authors: Marchi Nicola Andrea , Ramponi Cristina , Hirotsu Camila , Haba‐Rubio José , Lutti Antoine , Preisig Martin , Marques‐Vidal Pedro , Vollenweider Peter , Kherif Ferath , Heinzer Raphael , Draganski Bogdan 
Published: March 2020

ObjectiveThere is much controversy about the neurobiological mechanisms underlying the effects of sleep‐disordered breathing on the brain. The aim of this study was to investigate the association between markers of sleep‐related hypoxemia and brain anatomy.MethodsWe used data from a large‐scale cohort from the general population (n = 775, 50.6% males, age range = 45–86 years, mean age = 60.3 ± 9.9) that underwent full polysomnography and brain magnetic resonance imaging to correlate respiratory variables with regional brain volume estimates.ResultsAfter adjusting for age, gender, and cardiovascular risk factors, only mean oxygen saturation during sleep was associated with bilateral volume of hippocampus (right: p = 0.001; left: p < 0.001), thalamus (right: p < 0.001; left: p < 0.001), putamen (right: p = 0.001; left: p = 0.001), and angular gyrus (right: p = 0.011; left: p = 0.001). We observed the same relationship in left hemispheric amygdala (p = 0.010), caudate (p = 0.008), inferior frontal gyrus (p = 0.004), and supramarginal gyrus (p = 0.003). The other respiratory variables—lowest oxygen saturation, percentage of sleep time with oxygen saturation < 90%, apnea–hypopnea index, and oxygen desaturation index—did not show any significant association with brain volumes.InterpretationLower mean oxygen saturation during sleep was associated with atrophy of cortical and subcortical brain areas known for high sensitivity to oxygen supply. Their vulnerability to hypoxemia may contribute to behavioral phenotype and cognitive decline in patients with sleep‐disordered breathing. ANN NEUROL 2020;87:921–930
Pigmentierungschemie und radikalbasierter Kollagenabbau bei Alkaptonurie und Arthrose
Authors: Chow Wing Ying , Norman Brendan P. , Roberts Norman B. , Ranganath Lakshminarayan R. , Teutloff Christian , Bittl Robert , Duer Melinda J. , Gallagher James A. , Oschkinat Hartmut 
Published: March 2020

AbstractAlkaptonurie (AKU) ist eine seltene Krankheit, die durch einen hohen Gehalt an Homogentisinsäure (HGA) im Körper gekennzeichnet ist. Patienten leiden an Gewebe‐Ochronose: eine dunkelbraune Verfärbung, insbesondere des Gelenkknorpels, die zu schwerer früher Osteoarthropathie führt. Kein molekularer Mechanismus verbindet erhöhten HGA‐Gehalt mit Ochronose; weder die chemische Identität des Pigments ist bekannt, noch wie es den Abbau des Gelenkknorpels induziert. Hier geben wir wichtige Einblicke in die mit HGA verbundene Pigmentzusammensetzung und die Kollagenstörung im AKU‐Knorpel. Synthetisches Pigment und pigmentiertes menschliches Knorpelgewebe zeigten beide Hydrochinon‐ähnliche NMR‐Signalmuster. EPR‐Spektroskopie zeigte, dass das synthetische Pigment Radikale enthält. Darüber hinaus beobachteten wir eine strukturelle Störung der Kollagen‐Tripelhelix im pigmentierten menschlichen AKU‐Knorpel und im Knorpel von Patienten mit Arthrose. Wir schlagen vor, dass der Kollagenabbau über transiente Glycylradikale erfolgen kann, die bei AKU aufgrund der durch Pigmentierung erzeugten Redoxumgebung verstärkt gebildet werden.
Oxidation of Alkynyl Boronates to Carboxylic Acids, Esters, and Amides
Authors: Li Chenchen , Zhao Pei , Li Ruoling , Zhang Bing , Zhao Wanxiang 
Published: March 2020

AbstractA general efficient protocol was developed for the synthesis of carboxylic acids, esters, and amides through oxidation of alkynyl boronates, generated directly from terminal alkynes. This protocol represents the first example of C(sp)−B bond oxidation. This approach displays a broad substrate scope, including aryl and alkyl alkynes, and exhibits excellent functional group tolerance. Water, primary and secondary alcohols, and amines are suitable nucleophiles for this transformation. Notably, amino acids and peptides can be used as nucleophiles, providing an efficient method for the synthesis and modification of peptides. The practicability of this methodology was further highlighted by the preparation of pharmaceutical molecules.