bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non‐syndromic anophthalmia/microphthalmia can be caused by a PORCN variant inherited in X‐linked recessive manner
Authors: Wawrocka Anna , Walczak‐Sztulpa Joanna , Pawlak Marta , Gotz‐Wieckowska Anna , Krawczynski Maciej R. 
Published: October 2020

AbstractAnophthalmia and microphthalmia (A/M) represent severe developmental ocular malformations, corresponding, respectively, to absent eyeball or reduced size of the eye. Both anophthalmia and microphthalmia may occur in isolation or as part of a syndrome. Genetic heterogeneity has been demonstrated, and many genes have been reported to be associated with A/M. The advances in high‐throughput sequencing have proven highly effective in defining the molecular basis of A/M. Nevertheless, there are still many patients with unsolved genetic background of the disease, who pose a significant challenge in the molecular diagnostics of A/M. Here we describe a family, with three males affected with the non‐syndromic A/M. Whole exome‐sequencing performed in Patient 1, revealed the presence of a novel probably pathogenic variant c.734A>G, (p.[Tyr245Cys]) in the PORCN gene. Pedigree analysis and segregation of the identified variant in the family confirmed the X‐linked recessive pattern of inheritance. This is the first report of X‐linked recessive non‐syndromic A/M. Until now, pathogenic variants in the PORCN gene have been identified in the patients with Goltz syndrome, but they were inherited in X‐linked dominant mode. The ocular phenotype is the only finding observed in the patients, which allows to exclude the diagnosis of Goltz syndrome.
Clericuzio‐type poikiloderma with neutropenia in a patient from India
Authors: Bishnoi Anuradha , Jamwal Manu , Das Reena , Scaria Vinod , Vishwajeet Vikarn , De Dipankar , Saikia Uma Nahar , Mahajan Rahul 
Published: October 2020

AbstractA 9‐year‐old boy presented for evaluation of variegated skin pigmentation. Palms and soles revealed honeycombed hyperpigmented hyperkeratosis. Irregular, firm, skin coloured nodules suggestive of cutaneous calcification were present on both elbows. Total leucocyte count and absolute neutrophil count were 3720/mm3 and 420/mm3 respectively. The neutropenia was not cyclical. Systematic analysis of the whole exome data revealed a homozygous mutation in USB1 gene; chr16:g.58043892TA>‐[1/1]. A final diagnosis of poikiloderma with neutropenia‐ Clericuzio type (PNC) was made. Naegeli Franceschetti Jadassohn, dermatopathia pigmentosa reticularis, PNC and dyskeratosis congenita, all can present with overlapping cutaneous manifestations. Subtle clinical details like thickened nails, hyperextensible joints, calcinosis cutis, characteristic facies and a preceding erythematopapular rash strongly favor the diagnosis of PNC. The index case highlights two novel findings: obliterated dermatoglyphics and mucin deposition (features not described hitherto in PNC).
Socioeconomic Status Mediates Racial Differences Seen Using theAT(N)Framework
Authors: Meeker Karin L. , Wisch Julie K. , Hudson Darrell , Coble Dean , Xiong Chengjie , Babulal Ganesh M. , Gordon Brian A. , Schindler Suzanne E. , Cruchaga Carlos , Flores Shaney , Dincer Aylin , Benzinger Tammie L. , Morris John C. , Ances Beau M. 
Published: October 2020

ObjectivesAfrican Americans are at greater risk for developing Alzheimer's disease (AD) dementia than non‐Hispanic whites. In addition to biological considerations (eg, genetic influences and comorbid disorders), social and environmental factors may increase the risk of AD dementia. This paper (1) assesses neuroimaging biomarkers of amyloid (A), tau (T), and neurodegeneration (N) for potential racial differences and (2) considers mediating effects of socioeconomic status (SES) and measures of small vessel and cardiovascular disease on observed race differences.MethodsImaging measures of AT(N) (amyloid and tau positron emission tomography [PET]) structural magnetic resonance imaging (MRI), and resting state functional connectivity (rs‐fc) were collected from African American (n = 131) and white (n = 685) cognitively normal participants age 45 years and older. Measures of small vessel and cardiovascular disease (white matter hyperintensities [WMHs] on MRI, blood pressure, and body mass index [BMI]) and area‐based SES were included in mediation analyses.ResultsCompared to white participants, African American participants had greater neurodegeneration, as measured by decreased cortical volumes (Cohen'sf2= 0.05,p< 0.001). SES mediated the relationship between race and cortical volumes. There were no significant race effects for amyloid, tau, or rs‐fc signature.InterpretationModifiable factors, such as differences in social contexts and resources, particularly area‐level SES, may contribute to observed racial differences in AD. Future studies should emphasize collection of relevant psychosocial factors in addition to the development of intentional diversity and inclusion efforts to improve the racial/ethnic and socioeconomic representativeness of AD studies. ANN NEUROL 2021;89:254–265
A Grounded Theory of Intraoperative Team Members’ Decision Making Regarding Surgical Attire Guideline Adherence
Authors: Mayes Carole G. 
Published: October 2020

ABSTRACTSurgical attire guidelines (SAGs) assist perioperative nurses with minimizing the risk of patients developing surgical site infections. However, some intraoperative team members fail to fully adhere to SAGs, which may put patients at risk. Because there is a lack of published literature on the reasons for intraoperative team members’ SAG nonadherence, I undertook a grounded theory study to explore the decision making of intraoperative team members related to the AORN SAG. The resulting model identifies the factors that affect decision making regarding SAG adherence, including personal identity needs, adherence anchoring activities, SAG awareness, direction from authority figures and organizations, guideline evidence strength, and resource availability. After weighing the influence of each factor, team members decide to what extent they will adhere to the SAG. The theory also provides guidance for enhancing adherence decisions.
Clinical Issues—November 2020
Authors: Seeman Kristyn 
Published: October 2020

THIS MONTH
Using adhesive tape for patient positioning
Key words: adhesive tape, surgical tape, patient positioning, pressure injury, contamination.
Border sterility of open sterile wrappers
Key words: wrapped sterile item, unsterile border, wrapper flap, contaminated, aseptic technique.
Cost per minute of OR time
Key words: cost comparison, direct costs, cost savings, perioperative efficiency, product evaluation.
Packages containing an incorrect number of suture needles
Key words: multipack, retained surgical item (RSI), counting, needle, package.
An efficient plasticizer based on waste cooking oil: Structure and application
Authors: Liu Dekai , Shen Yirui , Wai Phyu Thin , Agus Haryono , Zhang Pingbo , Jiang Pingping , Nie Zhixin , Jiang Guoqiang , Zhao Huihang , Zhao Minzhong 
Published: October 2020

AbstractRecently, phthalates have been continuously banned in numerous fields by many countries. Therefore, the development of sustainable and efficient plasticizers has become particularly urgent. The waste cooking oil was used as the main raw materials in this study to synthesize an efficient plasticizer (acetylated‐fatty acid methyl ester‐trimellitic acid ester, AC‐FAME‐TAE). The structure of AC‐FAME‐TAE was characterized by FT‐IR and 1H NMR. The performance of the poly(vinyl chloride) (PVC) plasticized by AC‐FAME‐TAE was tested and compared with those of the PVC plasticized with di‐2‐ethylhexyl phthalate (DOP) and EFAME (epoxy fatty acid methyl ester), respectively. DSC results indicated that AC‐FAME‐TAE had excellent plasticizing efficiency for PVC. The mechanical properties of PVC plasticized by AC‐FAME‐TAE were as comparable as PVC plasticized by DOP from the results of tensile test. In addition, the PVC plasticized by AC‐FAME‐TAE had excellent thermal stability and solvent resistance by the results of leaching test and TGA.
Curing characteristics, kinetics, and thermal properties of multifunctional fluorene benzoxazines containing hydroxyl groups
Authors: He Xuan‐Yu , Wang Ting , Pan Zhong‐Cheng , Dayo Abdul Qadeer , Wang Jun , Liu Wen‐Bin 
Published: October 2020

AbstractIn this article, 9, 9‐bis (4‐aminophenyl)‐2, 7‐dihydroxy‐fluorene (BADHF) was synthesized using methylsulfonic acid as catalyzer by direct condensation. Two kinds of novel multifunctional benzoxazine monomers containing fluorenyl groups and hydroxyl groups (MB‐FH) were obtained from the chemical reaction of BADHF, salicylaldehyde, paraformaldehyde, and ethanolamine (or diethyleneglycolamine) through the adoption of o‐hydroxy‐benzylamine method and one‐step Mannich condensation reaction method. In the traditional three‐step synthesis method, the double bond reduction process took 8–12 h, but in this article, it only took 15 min. The structures of MB‐FH monomers and their intermediates were characterized by Fourier transform infrared spectroscopy (FTIR), 1H nuclear magnetic resonance (1H NMR). The curing behaviors, curing kinetics, and thermal properties of MB‐FH monomers were tested by using a dynamic rheometer, differential scanning calorimeter (DSC), FTIR, dynamic mechanical analysis (DMA), and thermogravimetric analyzer (TGA). The curing induction time can be apparently shortened by the introduction of hydroxyl groups into benzoxazine monomers, and it can catalyze the ring‐opening polymerization of oxazine rings at lower temperatures, and improve the interaction of hydrogen bonds in the structure of polybenzoxazine.
Influence of fused filament fabrication parameters on tensile properties of polylactide/layered silicate nanocomposite using response surface methodology
Authors: Ginoux Geoffrey , Vroman Isabelle , Alix Sébastien 
Published: October 2020

AbstractThis study aimed at assessing and optimizing the influence of printing speed and extrusion temperature in a fused filament fabrication (FFF) process on the tensile properties of a polylactide/layered silicate nanocomposite. Mathematical models using Doehlert designs were formulated to examine factor and interaction effects. The models were corroborated by measurements using capillary rheology, tomographic images, and crystallinity analyses to find physical explanations for the differences in tensile properties. The tensile properties were a non‐monotonic function of printing speed, which may be due to various deposition defects that influence the porosity of composite tensile specimens. This study provides new insights into FFF process optimization regarding rheological behavior and mesostructure of nanocomposite by highlighting new modes of deposition defects that originate from process parameter settings and materials. The results contribute to the properties mastery of FFF‐processed materials.
Epistemology, epistemic belief, personal epistemology, and epistemics: A review of concepts as they impact information behavior research
Authors: Kelly Matthew 
Published: October 2020

AbstractA review of a range of epistemic concepts that are commonly researched was conducted with reference to conventional epistemology and with reference to foundational approaches to justification. These were assessed in relation to previous research undertaken linking information behavior and experience with paradigm, metatheory, and discourse. This research assesses how the epistemic concept is treated, both within information science and within disciplines that have affinities to the topics or agents that have been the subject of inquiry within the field. An attempt is made to clarify the types of connections that are associated with the epistemic concept and to provide a clearer view of how research focused on information behavior might consider the questions underpinning assumptions relating to knowledge and knowing. The symbiotic connection between epistemics and information science is advanced as a suitably nuanced conception of socially organized knowledge from which to define the appropriate level at which knowledge claims can be usefully advanced. It is proposed that fostering a better understanding of epistemics as a research practice might also provide for the development of a range of insights and methods that reflect the dynamic context within which the study of information behavior and information experience is located.
Dynamic changes of peripheral blood lymphocyte subsets in acute ischemic stroke and prognostic value
Authors: Xiao Jun , Qiu Qian‐Wen , Qin Chuan , Tao Ran , Qiao Su‐Ya , Chen Man , Pan Deng‐Ji , Tian Dai‐Shi 
Published: October 2020

AbstractObjectiveTo explore dynamic changes of peripheral blood lymphocyte subsets in patients with acute ischemic stroke (AIS) and the relationship with stroke severity and long‐term outcomes.MethodsA total of 96 consecutive patients with AIS and 28 age‐ and gender‐matched healthy controls were recruited. Peripheral blood samples were collected, and the percentages of lymphocyte subsets were analyzed by flow cytometry. The dynamic changes in lymphocyte subsets and their correlation with clinical parameters, such as National Institutes of Health Stroke Scale (NIHSS) scores at onset and modified Rankin scale (mRS) scores 3 months later, were evaluated.ResultsIn our study, we observed a decrease in the percentages of T‐lymphocytes (T cells), helper/inducible T‐lymphocytes (Th cells) and suppressor/cytotoxic T‐lymphocytes (Ts cells) in AIS patients as compared to controls. The frequencies of T cells and Ts cells on day 8–14 after stroke in NIHSS ≤4 group were significantly higher than those in NIHSS >4 group. The percentages of T cells and Th cells on day 1–3 after stroke in the mRS ≤2 group were higher than those in the mRS >2 group.ConclusionThe frequencies of T cells, Th cells, and Ts cells in AIS are declined dramatically at least 14 days after stroke. Lower frequencies of T cells and Ts cells on day 8–14 after stroke represent more severe disease conditions, and the percentages of T cells and Th cells within 72 hr after stroke are negatively correlated with 3‐month outcomes, which might have a potential for predicting long‐term prognosis of stroke.
Overlapping tumor‐specific expression of p53, p16INK4a, and sirtuin 1 in Bowen's disease: A case report
Authors: Takada Tomoaki 
Published: October 2020

AbstractUnderstanding the impact of inactivating mutations in SIRT1 on the p53 and p16 tumor suppressor genes may yield new insight into the oncogenic mechanisms underlying Bowen's disease.
Late myocardial sequelae of electrical injury
Authors: Koren Ofir , Paz Ehud , Rozner Ehud , Mahamid Muhamad , Turgeman Yoav 
Published: October 2020

AbstractElectrocution poses serious complications seen mostly at the time of the event. Physicians and patients are usually not aware of the progressive nature and its potentially delayed effect as demonstrated in our case. We believe that a risk stratification model should be designed to guide physicians for proper management.
Cerebral cryptococcosis with pseudo‐meningiomatous revelation?
Authors: Hazim Asmaa , Amriss Omar 
Published: October 2020

AbstractWe report the case of a 28‐year‐old woman with history of lupus treated by Mycophenolate Mofetil and admitted for febrile meningeal syndrome associated with diplopia. Both initial and control brain MRI showed pseudo‐meningiomatous lesion while second CSF microscopy revealed characterizing images of Cryptococcus neoformans.
Transport of Lipophilic Anti‐Tuberculosis Drug Benzothiazone‐043 in Ca3(PO4)2 Nanocontainers
Authors: Rudolph David , Redinger Natalja , Schaible Ulrich E. , Feldmann Claus 
Published: October 2020

Abstract1,3‐Benzothiazin‐4‐one‐043 (BTZ043) is a novel anti‐mycobacterial agent for tuberculosis (TB) therapy with highly hydrophobic properties. In order to enhance local drug concentrations by improved administration and delivery to the site of the mycobacterial infection, we suggest BTZ043/Toc@Ca(ds)2@Ca3(PO4)2 nanocontainers made via a microemulsion approach for drug delivery (Toc: tocopherol; ds: dodecylsulfate). Based on our concept, the surfactant of the microemulsion itself is used to stabilize the droplet phase by interaction with Ca2+, followed by the formation of an inorganic Ca3(PO4)2 sphere wall in one‐pot reaction. Tocopherol (vitamin E) was used as biocompatible droplet phase of the microemulsion to dissolve the highly lipophilic BTZ043. According to electron microscopy and electron spectroscopy, the resulting BTZ043/Toc@Ca(ds)2@Ca3(PO4)2 nanocontainers exhibit an outer diameter of 28±8 nm and a sphere wall of 4±1 nm. The inner cavity, 18±7 nm in diameter, is loaded with BTZ043 with a concentration of 30.5 μg/mL. First in vitro tests with murine bone marrow derived macrophages infected with Mycobacterium tuberculosis show promising antibiotic activity of the BTZ043/Toc@Ca(ds)2@Ca3(PO4)2 nanocontainers.
A design methodology for matching smart health requirements
Authors: Bellandi Valerio , Ceravolo Paolo , Cristiano Alessia , Damiani Ernesto , Sanna Alberto , Trojaniello Diana 
Published: October 2020

SummaryAs now well established, the world population is aging rapidly and, according to World Health Organization (WHO), the amount of people aged 60 years and older is expected to total 2 billion in 2050. For this reason, an emerging important issue is the definition of a new generation of healthcare platforms capable of monitoring people's quality of life. In this article, we propose a new methodology that supports the entire requirement elicitation process starting from the initial phase of gathering the requirements, both clinical, technological, and end‐user, up to the choice of the most suitable solution. Our proposal provides a new new iterative model in the smart healthcare field research area. Furthermore we apply our proposal in a real scenario and we report the end‐to‐end implementation of the proposed methodology.
Internet of Things technology in mineral remote sensing monitoring
Authors: Liu Yanbing , Dhakal Sanjev 
Published: October 2020

AbstractAt present, the rapid development of the national economy consumes a lot of mineral resources, but the national resource extraction efficiency is low. The traditional prospecting methods consume time, money, and personnel, which cannot meet the national demand for resources in a short time. Therefore, technological innovation is needed to reduce consumption in all aspects. With the continuous development of Internet of Things technology, its application is also more extensive. This paper studies the application of Internet of Things technology in mineral remote sensing monitoring. First of all, this research mainly uses the wireless communication technology in the Internet of Things to achieve data transmission and sharing in a short distance and, second, based on the remote sensing monitoring results of the mine environment to comprehensively understand the mining area and find the suitable mining mineral resources at the fastest speed; finally, the dynamic frame time slot ALOHA algorithm is used to estimate the existing data to ensure the availability of the data. The experimental data show that vector point encryption is performed on the center line of the mine at intervals of 10, 15, 20, 30, and 50 m, respectively, and the dynamic frame slot algorithm is used to calculate the appropriate mine mining curve radius. The experimental results show that the application of Internet of Things technology in mineral remote sensing monitoring can accelerate the mining of mineral resources.
Combined endoscopic and transoral resection of a high‐staged juvenile nasopharyngeal angiofibroma: A pictorial essay
Authors: Lao Wilson P. , Lagabon Kristelle J. , Arom Gabriel A. , Walker Paul C. , Lee Steve C. 
Published: October 2020

AbstractJuvenile nasopharyngeal angiofibromas (JNAs) are highly vascular and benign tumors that can expand into the skull base. Delay of treatment can result in intracranial invasion, requiring extensive open approaches such as a facial translocation, maxillary swing, or an orbitozygomatic craniotomy. We describe a single‐stage, combined endoscopic and transoral approach on a 14‐year‐old male with extensive high‐stage dumbbell‐shaped JNA involving the infratemporal fossa, orbit, buccal space, and intracranial extension into Meckel's cave. Successful resection of the tumor and good postoperative outcome was achieved. A transoral approach allowed for greater access to the infratemporal fossa, where endonasal resection was not possible, allowing for improved visualization, greater traction, and dissection. In select highly staged JNAs with significant lateral extension and intracranial involvement, successful and complete resection may be accomplished with this combined approach. Utilization of this approach avoids the morbidity of more invasive open approaches.
Comparison of endoscopic band ligation devices used for colonic diverticular bleeding: in vivo animal study
Authors: Shiratori Yasutoshi , Ikeya Takashi , Suzuki Koyu , Yamamoto Kazuki , Yoshimoto Takaaki , Takasu Ayaka , Oguri Noriaki , Okamoto Takeshi , Okuyama Syuhei , Takagi Koichi , Fukuda Katsuyuki 
Published: October 2020

AbstractBackground and AimEndoscopic band ligation (EBL), used for the treatment of colonic diverticular bleeding, has a lower rebleeding rate than endoscopic clipping. However, different devices are used in Japan and the Western countries; no animal studies have been conducted to elucidate the safety of such devices. We compared two EBL devices, the first used in Japan and the second used in Western countries.Methods and ResultsThe Japanese and Western EBL devices were compared by assessing the EBL safety at 40 sites in an animal model with a normal colon that is anatomically similar to the human colon. Macroscopic and pathological examinations were performed to evaluate the layer ligated by the band and the presence of perforation. The findings on day 1 and day 7 after EBL were compared. The ligated layer was the muscularis propria at 39 sites; the layer was not evaluated at one site where the band was unintentionally removed during the endoscopic procedure. Pathologically, there was no perforation at any of the assessed sites. There was no statistical difference in any of the pathological variables between the two devices or between days 1 and 7 after EBL. The total procedure time was significantly shorter with the Western EBL device.ConclusionsIn this animal study, both evaluated devices were safe for EBL, without differences in the macroscopic and pathological variables after EBL. Ligation of the muscularis propria layer did not result in perforation.