bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional dentition and changes in dietary patterns among older adults in Thailand
Authors: Gaewkhiew Piyada , Sabbah Wael , Bernabé Eduardo 
Published: October 2020

AbstractObjective:To investigate the relationship between functional dentition (FD) and changes in dietary patterns (DP) in older adults.Design:This was a 12-month prospective study, with dental examinations at baseline and questionnaires at baseline and follow-up. Dentition was classified as FD (containing ≥10 occlusal contacts), non-FD with dentures and non-FD without dentures. A 154-item FFQ assessed dietary intake in the previous month. Food items (servings/d) were combined into twenty-two food groups based on their similar nutrient profile, culinary use and previous studies in Thailand. DP were identified through factor analysis of baseline intake and applied scores were used to estimate changes in DP scores. The association between baseline FD (exposure) and change in each DP score (outcome) was tested in linear regression models adjusting for baseline socio-demographic factors, behaviours, chronic conditions, medications, total energy intake and DP score.Setting:Phetchaburi, Thailand.Participants:Totally, 788 community dwellers aged ≥ 60 years.Results:In total, 651 participants were retained after 12 months (82·6 % retention rate), of whom 14·1 % had FD. Having an FD was positively associated with larger increases in vegetable intake. Three DP were identified. Participants with FD had larger increases in healthy (0·13; 95 % CI: −0·13, 0·39) and carbohydrate-rich diets intake (0·12; 95 % CI: −0·17, 0·40) as well as larger reductions in meat-rich diet intake (−0·12; 95 % CI: −0·45, 0·21) than those with neither FD nor dentures. However, these differences were not significant.Conclusion:There was little support for an association between baseline FD and changes in DP.
The interplay between fast-food outlet exposure, household food insecurity and diet quality in disadvantaged districts
Authors: van der Velde Laura A , Zitman Femke MP , Mackenbach Joreintje D , Numans Mattijs E , Kiefte-de Jong Jessica C 
Published: October 2020

AbstractObjective:The current study aimed to explore the interplay between food insecurity, fast-food outlet exposure and dietary quality in disadvantaged neighbourhoods.Design:In this cross-sectional study, main associations between fast-food outlet density and proximity, food insecurity status and dietary quality were assessed using Generalized Estimating Equation analyses. We assessed potential moderation by fast-food outlet exposure in the association between food insecurity status and dietary quality by testing for effect modification between food insecurity status and fast-food outlet density and proximity.Setting:A deprived urban area in the Netherlands.Participants:We included 226 adult participants with at least one child below the age of 18 years living at home.Results:Fast-food outlet exposure was not associated with experiencing food insecurity (fast-food outlet density: b = −0·026, 95 % CI = −0·076; 0·024; fast-food outlet proximity: b = −0·003, 95 % CI = −0·033; 0·026). Experiencing food insecurity was associated with lower dietary quality (b = −0·48 per unit increase, 95 % CI = −0·94; −0·012). This association was moderated by fast-food outlet proximity (Pinteraction = 0·008), and stratified results revealed that the adverse effect of food insecurity on dietary quality was more pronounced for those with the nearest fast-food outlet located closer to the home.Conclusions:Food insecurity but not fast-food outlet density is associated with dietary quality. However, the association between food insecurity and dietary quality may be modified by the food environment. These findings could inform policymakers to promote a healthier food environment including less fast-food outlets, with particular emphasis on areas with high percentages of food insecure households.
Galectin-3 Expression in Pancreatic Cell Lines Under Distinct Autophagy-Inducing Stimulus
Authors: da Silva Filho Antônio Felix , de Sousa Lizandra Maia , Consonni Silvio Roberto , da Rocha Pitta Maira Galdino , Carvalho Hernandes Faustino , de Melo Rêgo Moacyr Jesus Barreto 
Published: October 2020

Abstract
Einfluss belastender Kindheitserfahrungen bei akuten Psychosen und ihr Zusammenhang mit Schwere und kurzfristigem Verlauf
Authors: Nischk Daniel , Kügler Friederike , Rockstroh Brigitte , Schalinski Inga 
Published: October 2020

Zusammenfassung. Theoretischer Hintergrund: Misshandlung, Missbrauch und Vernachlässigung (MMV) in der Kindheit stehen mit einem erhöhten Risiko für schizophrene Spektrumsstörungen sowie einem schlechten Verlauf in Zusammenhang. Fragestellung: 1.) Wie verteilen sich die Schweregrade von MMV bei Patient_innen im Vergleich zu Gesunden? 2.) Ist MMV mit höherer Erkrankungsschwere zu Behandlungsbeginn sowie 3.) einem schlechteren Verlauf einer akuten Psychose assoziiert? Methode: MMV wurde bei Patient_innen mit schizophrenen Spektrumsstörungen ( n = 101) und Gesunden ( n = 50) erhoben. Die Patient_innen wurden bei der stationären Aufnahme (t1), Entlassung (t2) und sechs Monate später (t3) untersucht. Ergebnisse: 1.) Gegenüber Kontrollpersonen zeigte sich ein ansteigender Anteil von Patient_innen mit mittleren und hohen MMV-Schweregraden. MMV-Erfahrungen waren zudem 2.) mit häufigerer psychiatrischer Komorbidität sowie 3.) mit höherer Depressivität, störungsunspezifischer Symptomatik und geringerer Lebenszufriedenheit im Verlauf assoziiert. Schlussfolgerungen: MMV-Erfahrungen sind für Erkrankungschwere und akuten Verlauf von schizophrenen Spektrumsstörungen bedeutsam.
Genetic aberrations in DNA repair pathways: a cornerstone of precision oncology in prostate cancer
Authors: Lozano Rebeca , Castro Elena , Aragón Isabel M. , Cendón Ylenia , Cattrini Carlo , López-Casas Pedro P. , Olmos David 
Published: October 2020

AbstractOver the past years, several studies have demonstrated that defects in DNA damage response and repair (DDR) genes are present in a significant proportion of patients with prostate cancer. These alterations, particularly mutations in BRCA2, are known to be associated with an increased risk of developing prostate cancer and more aggressive forms of the disease. There is growing evidence that certain DDR gene aberrations confer sensitivity to poly-(ADP ribose) polymerase inhibitors and/or platinum chemotherapy, while other defects might identify cases that are more likely to benefit from immune checkpoint inhibition. The potential prognostic impact and relevance for treatment selection together with the decreasing costs and broader accessibility to next-generation sequencing have already resulted in the increased frequency of genetic profiling of prostate tumours. Remarkably, almost half of all DDR genetic defects can occur in the germline, and prostate cancer patients identified as mutation carriers, as well as their families, will require appropriate genetic counselling. In this review, we summarise the current knowledge regarding the biology and clinical implications of DDR defects in prostate cancer, and outline how this evidence is prompting a change in the treatment landscape of the disease.
Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis
Authors: Wiernicki Bartosz , Dubois Hanne , Tyurina Yulia Y. , Hassannia Behrouz , Bayir Hülya , Kagan Valerian E. , Vandenabeele Peter , Wullaert Andy , Vanden Berghe Tom 
Published: October 2020

AbstractLipid peroxidation (LPO) drives ferroptosis execution. However, LPO has been shown to contribute also to other modes of regulated cell death (RCD). To clarify the role of LPO in different modes of RCD, we studied in a comprehensive approach the differential involvement of reactive oxygen species (ROS), phospholipid peroxidation products, and lipid ROS flux in the major prototype modes of RCD viz. apoptosis, necroptosis, ferroptosis, and pyroptosis. LC-MS oxidative lipidomics revealed robust peroxidation of three classes of phospholipids during ferroptosis with quantitative predominance of phosphatidylethanolamine species. Incomparably lower amounts of phospholipid peroxidation products were found in any of the other modes of RCD. Nonetheless, a strong increase in lipid ROS levels was detected in non-canonical pyroptosis, but only during cell membrane rupture. In contrast to ferroptosis, lipid ROS apparently was not involved in non-canonical pyroptosis execution nor in the release of IL-1β and IL-18, while clear dependency on CASP11 and GSDMD was observed. Our data demonstrate that ferroptosis is the only mode of RCD that depends on excessive phospholipid peroxidation for its cytotoxicity. In addition, our results also highlight the importance of performing kinetics and using different methods to monitor the occurrence of LPO. This should open the discussion on the implication of particular LPO events in relation to different modes of RCD.
Antigen presentation, autoantibody production, and therapeutic targets in autoimmune liver disease
Authors: Horst Andrea Kristina , Kumashie Kingsley Gideon , Neumann Katrin , Diehl Linda , Tiegs Gisa 
Published: October 2020

AbstractThe liver is an important immunological organ that controls systemic tolerance. The liver harbors professional and unconventional antigen-presenting cells that are crucial for tolerance induction and maintenance. Orchestrating the immune response in homeostasis depends on a healthy and well-toned immunological liver microenvironment, which is maintained by the crosstalk of liver-resident antigen-presenting cells and intrahepatic and liver-infiltrating leukocytes. In response to pathogens or autoantigens, tolerance is disrupted by unknown mechanisms. Intrahepatic parenchymal and nonparenchymal cells exhibit unique antigen-presenting properties. The presentation of microbial and endogenous lipid-, metabolite- and peptide-derived antigens from the gut via conventional and nonconventional mechanisms can educate intrahepatic immune cells and elicit effector responses or tolerance. Perturbation of this balance results in autoimmune liver diseases, such as autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis. Although the exact etiologies of these autoimmune liver diseases are unknown, it is thought that the disruption of tolerance towards self-antigens and microbial metabolites and lipids, as well as alterations in bile acid composition, may result in changes in effector cell activation and polarization and may reduce or impair protective anti-inflammatory regulatory T and B cell responses. Additionally, the canonical and noncanonical transmission of antigens and antigen:MHC complexes via trogocytosis or extracellular vesicles between different (non) immune cells in the liver may play a role in the induction of hepatic inflammation and tolerance. Here, we summarize emerging aspects of antigen presentation, autoantibody production, and the application of novel therapeutic approaches in the characterization and treatment of autoimmune liver diseases.
Modulation of complement activation by pentraxin-3 in prostate cancer
Authors: Stallone Giovanni , Netti Giuseppe Stefano , Cormio Luigi , Castellano Giuseppe , Infante Barbara , Pontrelli Paola , Divella Chiara , Selvaggio Oscar , Spadaccino Federica , Ranieri Elena , Sanguedolce Francesca , Pennella Antonio , Gesualdo Loreto , Carrieri Giuseppe , Grandaliano Giuseppe 
Published: October 2020

AbstractPentraxin 3 (PTX3) is an essential component of the innate immune system and a recognized modulator of Complement cascade. The role of Complement system in the pathogenesis of prostate cancer has been largely underestimated. The aim of our study was to investigate the role of PTX3 as possible modulator of Complement activation in the development of this neoplasia. We performed a single center cohort study; from January 2017 through December 2018, serum and prostate tissue samples were obtained from 620 patients undergoing prostate biopsy. A group of patients with benign prostatic hyperplasia (BPH) underwent a second biopsy within 12–36 months demonstrating the presence of a prostate cancer (Group A, n = 40) or confirming the diagnosis of BPH (Group B, N = 40). We measured tissue PTX3 protein expression together with complement activation by confocal microscopy in the first and second biopsy in group A and B patients. We confirmed that that PTX3 tissue expression in the first biopsy was increased in group A compared to group B patients. C1q deposits were extensively present in group A patients co-localizing and significantly correlating with PTX3 deposits; on the contrary, C1q/PTX3 deposits were negative in group B. Moreover, we found a significantly increased expression of C3a and C5a receptors within resident cells in group A patient. Interestingly, C1q/PTX3 deposits were not associated with activation of the terminal Complement complex C5b-9; moreover, we found a significant increase of Complement inhibitor CD59 in cancer tissue. Our data indicate that PTX3 might play a significant pathogenic role in the development of this neoplasia through recruitment of the early components of Complement cascade with hampered activation of terminal Complement pathway associated with the upregulation of CD59. This alteration might lead to the PTX3-mediated promotion of cellular proliferation, angiogenesis and insensitivity to apoptosis possible leading to cancer cell invasion and migration.
Image-guided cochlear access by non-invasive registration: a cadaveric feasibility study
Authors: Wang Jiang , Liu Hongsheng , Ke Jia , Hu Lei , Zhang Shaoxing , Yang Biao , Sun Shilong , Guo Na , Ma Furong 
Published: October 2020

AbstractImage-guided cochlear implant surgery is expected to reduce volume of mastoidectomy, accelerate recovery, and improve safety. The purpose of this study was to investigate the safety and effectiveness of image-guided cochlear implant surgery by a non-invasive registration method, in a cadaveric study. We developed a visual positioning frame that can utilize the maxillary dentition as a registration tool and completed the tunnels experiment on 5 cadaver specimens (8 cases in total). The accuracy of the entry point and the target point were 0.471 ± 0.276 mm and 0.671 ± 0.268 mm, respectively. The shortest distance from the margin of the tunnel to the facial nerve and the ossicular chain were 0.790 ± 0.709 mm and 1.960 ± 0.630 mm, respectively. All facial nerves, tympanic membranes, and ossicular chains were completely preserved. Using this approach, high accuracy was achieved in this preliminary study, suggesting that the non-invasive registration method can meet the accuracy requirements for cochlear implant surgery. Based on the above accuracy, we speculate that our method can also be applied to neurosurgery, orbitofacial surgery, lateral skull base surgery, and anterior skull base surgery with satisfactory accuracy.
Harnessing consumer smartphone and wearable sensors for clinical cancer research
Authors: Low Carissa A. 
Published: October 2020

AbstractAs smartphones and consumer wearable devices become more ubiquitous, there is a growing opportunity to capture rich mobile sensor data continuously, passively, and in real-world settings with minimal burden. In the context of cancer, changes in these passively sensed digital biomarkers may reflect meaningful variation in functional status, symptom burden, quality of life, and risk for adverse clinical outcomes. These data could enable real-time remote monitoring of patients between clinical encounters and more proactive, comprehensive, and personalized care. Over the past few years, small studies across a variety of cancer populations support the feasibility and potential clinical value of mobile sensors in oncology. Barriers to implementing mobile sensing in clinical oncology care include the challenges of managing and making sense of continuous sensor data, patient engagement issues, difficulty integrating sensor data into existing electronic health systems and clinical workflows, and ethical and privacy concerns. Multidisciplinary collaboration is needed to develop mobile sensing frameworks that overcome these barriers and that can be implemented at large-scale for remote monitoring of deteriorating health during or after cancer treatment or for promotion and tailoring of lifestyle or symptom management interventions. Leveraging digital technology has the potential to enrich scientific understanding of how cancer and its treatment affect patient lives, to use this understanding to offer more timely and personalized support to patients, and to improve clinical oncology outcomes.
A statistical study of plasmoids associated with a post-CME current sheet
Authors: Patel Ritesh , Pant Vaibhav , Chandrashekhar Kalugodu , Banerjee Dipankar 
Published: October 2020

Context. Coronal mass ejections (CMEs) are often observed to be accompanied by flare, current sheets, and plasmoids/plasma blobs. 2D and 3D numerical simulations and observations reported plasmoids moving upward as well as downward along the current sheet.
Aims. We aim to investigate the properties of plasmoids observed in the current sheet formed after an X-8.3 flare and followed by a fast CME eruption on September 10, 2017 using extreme-ultraviolet (EUV) and white-light coronagraph images. The main goal is to understand the evolution of plasmoids in different spatio-temporal scales using existing ground- and space-based instruments.
Methods. We identified the plasmoids manually and tracked them along the current sheet in the successive images of Atmospheric Imaging Assembly (AIA) taken at the 131 Å pass band and in running difference images of the white-light coronagraphs, K-Cor and LASCO/C2. The location and size of the plasmoids in each image were recorded and analyzed, covering the current sheet from the inner to outer corona.
Results. We find that the observed current sheet has an Alfvén Mach number of 0.018−0.35. The fast reconnection is also accompanied by plasmoids moving upward and downward. We identified 20 downward-moving and 16 upward-moving plasmoids using AIA 131 Å images. In white-light coronagraph images, only upward-moving plasmoids are observed. Our analysis shows that the downward-moving plasmoids have an average width of 5.92 Mm, whereas upward-moving blobs have an average size of 5.65 Mm in the AIA field of view (FOV). The upward-moving plasmoids, when observed in the white-light images, have an average width of 64 Mm in the K-Cor, which evolves to a mean width of 510 Mm in the LASCO/C2 FOV. Upon tracking the plasmoids in successive images, we find that downward- and upward-moving plasmoids have average speeds of ∼272 km s−1 and ∼191 km s−1, respectively in the EUV channels of observation. The average speed of plasmoids increases to ∼671 km s−1 and ∼1080 km s−1 in the K-Cor and LASCO/C2 FOVs, respectively, implying that the plasmoids become super-Alfvénic when they propagate outward. The downward-moving plasmoids show an acceleration in the range of −11 km s−1 to over 8 km s−1. We also find that the null point of the current sheet is located at ≈1.15 R⊙, where bidirectional plasmoid motion is observed.
Conclusions. The width distribution of plasmoids formed during the reconnection process is governed by a power law with an index of −1.12. Unlike previous studies, there is no difference in trend for small- and large-scale plasmoids. The evolution of width W of the plasmoids moving at an average speed V along the current sheet is governed by an empirical relation: V = 115.69W0.37. The presence of accelerating plasmoids near the neutral point indicates a longer diffusion region as predicted by MHD models.
Under-Recognition of Neonatal Acute Kidney Injury and Lack of Follow-Up
Authors: Roy Jean-Philippe , Goldstein Stuart L. , Schuh Meredith P. 
Published: October 2020

Objective Acute kidney injury (AKI) incidence is 30% in neonatal intensive care units (NICU). AKI is associated with increased mortality and risk of chronic kidney disease (CKD) in children. To assess follow-up and early CKD, we retrospectively reviewed outcomes of Cincinnati Children's Hospital Medical Center (CCHMC) cohort of neonates from the AWAKEN trial (2014).Study Design Data from 81 CCHMC patients were extracted from the AWAKEN dataset. KDIGO (Kidney Disease: Improving Global Outcomes) criteria for serum creatinine (SCr) and urine output (UOP) <1 mL/kg/h, reported per 24 hours on postnatal days 2 to 7, were used to define AKI. Charts were reviewed until May 2019 for death, nephrology consult, AKI diagnosis on discharge summary, follow-up, and early CKD at >6 months of age (defined as: estimated glomerular filtration rate < 90 mL/min/1.73 m2, hyperfiltration, proteinuria, hypertension, or abnormal ultrasound). Patients were considered to have renal follow-up if they had ≥1 follow-up visit containing: SCr, urinalysis, or blood pressure measurement.Results Seventy-seven patients had sufficient data to ascertain AKI diagnosis. In total 47 of 77 (61%) were AKI+ by SCr or UOP criteria (20 stage 1, 14 stage 2, 13 stage 3). Four died during their admission and five were removed from CKD analyses due to urologic anomalies. AKI-UOP alone outnumbered AKI-SCr (45 AKI+ vs 5 AKI+ for all stages). 33% of patients had <2 SCr measured while inpatient. Only 3 of 47 AKI+ patients had a nephrology consult (all stage 3 by SCr) and 2 of 47 had AKI included in discharge summary. 67% of AKI+ patients had follow-up. In total 10 of 43 (23%) AKI+ versus 12 of 25 (48%) AKI− patients had ≥1 marker of early CKD assessed after 6 months. Based on SCr, 3 of 7 (43%) AKI+ had hyperfiltration versus 0 of 7 (0%) AKI− (p = 0.19).Conclusion AKI is vastly under-recognized in the NICU, especially if based on SCr alone. This leads to insufficient follow-up to ascertain renal sequelae in this high-risk population.Key Points
Factors influencing the use of e-learning facilities by students in a private Higher Education Institution (HEI) in a developing economy
Authors: Eze Sunday C. , Chinedu-Eze Vera C. A. , Okike Clinton K. , Bello Adenike O. 
Published: October 2020

AbstractWhile research into the adoption of e-learning in Nigeria has mainly focused on its use in public Higher Education Institutions (HEIs), there is still a lack of research on factors affecting students’ use of e-learning in private HEIs in Nigeria. This study, therefore, explores factors influencing the use of e-learning by students in private HEIs in Nigeria using Technology-Organisation-Environment (TOE) framework. We use a data collection method encompassing semi-structured interviews with 15 students from L-University drawn purposefully from the Landmark directory and a hybrid thematic analysis to analyse the data. Our findings reveal that technology-related factors (ease of use, speed accessibility and service delivery), organisation-related factors (training support and diversity), environment-related factors (attitudes of the users) and impact-related factors (learning experience, skill development, academic performance, and degree of engagement) influence the students’ adoption of e-learning facilities. We develop an extended TOE framework that integrates the impact context which considers the students likely expectations if these facilities are fully adopted and implemented. The study also unveils techniques that may accelerate the development of e-learning structure in private HEIs and which could provide the opportunity of assisting communities of learners to adopt and use e-learning facilities regularly.