bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of public water supply fluoride concentration as an indicator of population exposure to fluoride in England 1995–2015
Authors: Roberts David J. , Morris J. , Wood A. , Verlander N. Q. , Leonardi G. S. , Fletcher T. 
Published: July 2020

AbstractPublic health monitoring of Community Water Fluoridation (CWF) schemes requires estimates of exposure to fluoride in public water supplies (PWS). We aimed to use routine data to estimate population exposure to PWS-fluoride in England and to determine whether PWS-fluoride exposure from 2005 to 2015 could be used as a proxy for exposure for 1995–2004, when fluoride concentration data that could be linked to population health data were unavailable. We calculated annual mean water supply zone PWS-fluoride concentrations from monitoring data for 1995–2015, stratified by fluoridation scheme-flagging. We allocated annual 2005–2015 mean PWS-fluoride concentrations to small area boundaries to describe population exposure within five concentration categories (< 0.1 to ≥ 0.7 mg/L). We compared zone-level 1995–2004 and 2005–2015 mean PWS-fluoride concentrations using Spearman correlation. Most (72%) of the population received PWS with < 0.2 mg/L fluoride and 10% with ≥ 0.7 mg/L. Fluoride concentrations in 1995–2004 and 2005–2015 were similar (median 0.11 mg/L (lower quartile–upper quartile (LQ–UQ) 0.06–0.17) and 0.11 mg/L (LQ–UQ 0.07–0.17), respectively) and highly correlated (coefficient 0.93) if un-fluoridated but differed (1995–2004 median 0.78 mg/L (LQ–UQ 0.59–0.92); 2005–2015 0.84 mg/L (LQ–UQ 0.72–0.95)) and correlated weakly (coefficient 0.31) if fluoridated. Fluoride concentrations in 2005–2015 approximate those in 1995–2004 but with a greater risk of misclassification in fluoridation schemes.
Predicting microcystin concentration action-level exceedances resulting from cyanobacterial blooms in selected lake sites in Ohio
Authors: Francy Donna S. , Brady Amie M.G. , Stelzer Erin A. , Cicale Jessica R. , Hackney Courtney , Dalby Harrison D. , Struffolino Pamela , Dwyer Daryl F. 
Published: July 2020

AbstractCyanobacterial harmful algal blooms and the toxins they produce are a global water-quality problem. Monitoring and prediction tools are needed to quickly predict cyanotoxin action-level exceedances in recreational and drinking waters used by the public. To address this need, data were collected at eight locations in Ohio, USA, to identify factors significantly related to observed concentrations of microcystins (a freshwater cyanotoxin) that could be used in two types of site-specific regression models. Real-time models include easily or continuously-measured factors that do not require that a sample be collected; comprehensive models use a combination of discrete sample-based measurements and real-time factors. The study sites included two recreational sites and six water treatment plant sites. Real-time models commonly included variables such as phycocyanin, pH, specific conductance, and streamflow or gage height. Many real-time factors were averages over time periods antecedent to the time the microcystin sample was collected, including water-quality data compiled from continuous monitors. Comprehensive models were useful at some sites with lagged variables for cyanobacterial toxin genes, dissolved nutrients, and (or) nitrogen to phosphorus ratios. Because models can be used for management decisions, important measures of model performance were sensitivity, specificity, and accuracy of estimates above or below the microcystin concentration threshold standard or action level. Sensitivity is how well the predictive tool correctly predicts exceedance of a threshold, an important measure for water-resource managers. Sensitivities > 90% at four Lake Erie water treatment plants indicated that models with continuous monitor data were especially promising. The planned next steps are to collect more data to build larger site-specific datasets and validate models before they can be used for management decisions.
Hidden Sites, Hidden Images, Hidden Meanings: Does the Location and Visibility of Motifsand Sites Correlate to Restricted or Open Access?
Authors: Domingo Inés , Smith Claire , Jackson Gary , Roman Didac 
Published: July 2020

AbstractUsing an ethnographic approach, this research assesses common assumptions in rock art research in terms of their validity for Aboriginal rock art sites in the Barunga region of the Northern Territory, Australia. In particular, we assess the potential and limits of the commonly held assumption that open or restricted access to sites and/or the meaning of motifs can be assessed by determining the visibility of the site or image within the landscape. This research calls into question some assumptions that are core to contemporary archaeological method and theory. Our results challenge the notion that a secluded location, or difficulty of access, is needed to restrict access to a site. “Hidden” sites do not need to be hidden, as site access is controlled by a plethora of cultural rules. Moreover, sites that appear to be hidden within the landscape may be open access sites, although access may be restricted for periods of time. Conversely, sites that are visible and accessible from a landscape perspective can be subject to restricted access, regulated through social rules. In addition, the results question the notion that the control of secret information in rock art sites is determined by the visibility and location of motifs and sites. Hidden meanings are not necessarily related to hidden locations or the low visibility of the art, since cultures can have many other ways of hiding meaning. Finally, the results of this study challenge the commonly held dichotomy between sacred/restricted access and secular/open access.
Applicability of computed tomography preoperative assessment of the LAA in LV summit ablations
Authors: Kuniewicz Marcin , Krupiński M. , Gosnell M. , Budnicka K. , Jakob N. , Karkowski G. , Urbańczyk-Zawadzka M. , Lelakowski J. , Walocha J. 
Published: July 2020

Abstract
Purpose
Ventricular arrhythmias originating from the left ventricular summit (LVS) may present with challenges for catheter ablation. Recently, the left atrial appendage (LAA) became a new vantage point for mapping and ablating arrhythmias from that region, but data of possible usefulness is limited.

Methods
From September to December 2019, we retrospectively analyzed 48 consecutive patient hearts (20 male; mean age 57.9y ± 11.56) undergoing diagnostic coronary vessel imaging in 64 dual-source computer tomography angiography (CTA). Distances from the LAA to the LVS, LAA shape type, and coronary arteries in the LVS region were measured. Also, we compared the true LVS area from CTA with a calculated formula derived from LVS definition.

Results
The mean LVS area calculated from the formula was 291.58 mm2 (± 115.5) while the true area calculated from CT was 263.33 mm2 (± 99.49) (p = 0.44). The mean inaccessible area was 133.42 mm2 (± 72.89), accessible 95.67 mm2 (± 72.77). The mean LAA coverage over LVS was 196.08 mm2—which is approximately 75% of LVS size in general. The most common LAA shape was chicken wing (50%); windsock has the highest accessible area coverage on average (80.23%), followed by chicken wing (59.88%), broccoli (47.72%), and cactus (46.98%). The mean distance from LAA to the surface was 5.14 mm (1.5 to 10 mm) and was not correlated with BMI. LAA has a 98% coverage over the point of transition between the great cardiac vein and anterior interventricular vein.

Conclusion
Angio-CT assessment of the LAA over the LVS structures may be helpful in decision making before an ablation procedure. LAA appears to be a promising mapping approach in LVS arrhythmias.
Is Mental Well-Being in the Oldest Old Different from That in Younger Age Groups? Exploring the Mental Well-Being of the Oldest-Old Population in Europe
Authors: Donisi Valeria , Tedeschi Federico , Gonzalez-Caballero Juan Luis , Cresswell-Smith Johanna , Lara Elvira , Miret Marta , Forsman Anna K. , Wahlbeck Kristian , Amaddeo Francesco , Kalseth Jorid 
Published: July 2020

AbstractThe oldest-old population is increasing in Europe, and greater focus is placed on promoting mental well-being (MWB) in this population. The European Welfare Models and Mental Wellbeing in Final Years of Life project aims to develop a better understanding of how best to promote positive MWB in the oldest-old population. Using a resources approach, the present study aimed to provide empirical evidence about the structure of MWB in the 80 + year age group and to compare this with the structure of MWB in the old (65–79 years) and adult (18–64 years) population. Twenty-eight items reflecting a focus on positive aspects of MWB were selected from the European Social Survey data (24 countries). After application of an exploratory approach using Exploratory Structural Equation Modelling, five- and six-factor model solutions were found to be statistically appropriate, and the results are consistent with the most widely studied dimensions of MWB. Despite specific differences in the factor models and item loadings, evaluation of formal invariance showed that dimensions built in the same way are comparable across age groups. Although explorative and not conclusive, the results of this study contribute insights into the multidimensional structure of MWB in the oldest-old population and provide a starting point for further research on promoting MWB in the later stages of life.
Kinematic analysis of a rolling tensegrity structure with spatially curved members
Authors: Schorr Philipp , Li Enrique Roberto Carrillo , Kaufhold Tobias , Hernández Jorge Antonio Rodríguez , Zentner Lena , Zimmermann Klaus , Böhm Valter 
Published: July 2020

AbstractIn this work, a tensegrity structure with spatially curved members is applied as rolling locomotion system. The actuation of the structure allows a variation of the originally cylindrical shape to a conical shape. Moreover, the structure is equipped with internal movable masses to control the position of the center of mass of the structure. To control the locomotion system a reliable actuation strategy is required. Therefore, the kinematics of the system considering the nonholonomic constraints are derived in this paper. Based on the resulting insight in the locomotion behavior a feasible actuation strategy is designed to control the trajectory of the system. To verify this approach kinematic analyses are evaluated numerically. The simulation data confirm the path following due to an appropriate shape change of the tensegrity structure. Thus, this system enables a two-dimensional rolling locomotion.
Investigating Mercury’s Environment with the Two-Spacecraft BepiColombo Mission
Authors: Milillo A. , Fujimoto M. , Murakami G. , Benkhoff J. , Zender J. , Aizawa S. , Dósa M. , Griton L. , Heyner D. , Ho G. , Imber S. M. , Jia X. , Karlsson T. , Killen R. M. , Laurenza M. , Lindsay S. T. , McKenna-Lawlor S. , Mura A. , Raines J. M. , Rothery D. A. , André N. , Baumjohann W. , Berezhnoy A. , Bourdin P. A. , Bunce E. J. , Califano F. , Deca J. , de la Fuente S. , Dong C. , Grava C. , Fatemi S. , Henri P. , Ivanovski S. L. , Jackson B. V. , James M. , Kallio E. , Kasaba Y. , Kilpua E. , Kobayashi M. , Langlais B. , Leblanc F. , Lhotka C. , Mangano V. , Martindale A. , Massetti S. , Masters A. , Morooka M. , Narita Y. , Oliveira J. S. , Odstrcil D. , Orsini S. , Pelizzo M. G. , Plainaki C. , Plaschke F. , Sahraoui F. , Seki K. , Slavin J. A. , Vainio R. , Wurz P. , Barabash S. , Carr C. M. , Delcourt D. , Glassmeier K.-H. , Grande M. , Hirahara M. , Huovelin J. , Korablev O. , Kojima H. , Lichtenegger H. , Livi S. , Matsuoka A. , Moissl R. , Moncuquet M. , Muinonen K. , Quèmerais E. , Saito Y. , Yagitani S. , Yoshikawa I. , Wahlund J.-E. 
Published: July 2020

AbstractThe ESA-JAXA BepiColombo mission will provide simultaneous measurements from two spacecraft, offering an unprecedented opportunity to investigate magnetospheric and exospheric dynamics at Mercury as well as their interactions with the solar wind, radiation, and interplanetary dust. Many scientific instruments onboard the two spacecraft will be completely, or partially devoted to study the near-space environment of Mercury as well as the complex processes that govern it. Many issues remain unsolved even after the MESSENGER mission that ended in 2015. The specific orbits of the two spacecraft, MPO and Mio, and the comprehensive scientific payload allow a wider range of scientific questions to be addressed than those that could be achieved by the individual instruments acting alone, or by previous missions. These joint observations are of key importance because many phenomena in Mercury’s environment are highly temporally and spatially variable. Examples of possible coordinated observations are described in this article, analysing the required geometrical conditions, pointing, resolutions and operation timing of different BepiColombo instruments sensors.
The social fabric of understanding: equilibrium, authority, and epistemic empathy
Authors: Jäger Christoph , Malfatti Federica Isabella 
Published: July 2020

AbstractWe discuss the social-epistemic aspects of Catherine Elgin’s theory of reflective equilibrium and understanding and argue that it yields an argument for the view that a crucial social-epistemic function of epistemic authorities is to foster understanding in their communities. We explore the competences that enable epistemic authorities to fulfil this role and argue that among them is an epistemic virtue we call “epistemic empathy”.
Obstacles, Interfacial Forms, and Turbulence: A Numerical Analysis of Soil–Water Evaporation Across Different Interfaces
Authors: Coltman Edward , Lipp Melanie , Vescovini Andrea , Helmig Rainer 
Published: July 2020

AbstractExchange processes between a turbulent free flow and a porous media flow are sensitive to the flow dynamics in both flow regimes, as well as to the interface that separates them. Resolving these complex exchange processes across irregular interfaces is key in understanding many natural and engineered systems. With soil–water evaporation as the natural application of interest, the coupled behavior and exchange between flow regimes are investigated numerically, considering a turbulent free flow as well as interfacial forms and obstacles. Interfacial forms and obstacles will alter the flow conditions at the interface, creating flow structures that either enhance or reduce exchange rates based on their velocity conditions and their mixing with the main flow. To evaluate how these interfacial forms change the exchange rates, interfacial conditions are isolated and investigated numerically. First, different flow speeds are compared for a flat surface. Second, a porous obstacle of varied height is introduced at the interface, and the effects the flow structures that develop have on the interface are analyzed. The flow parameters of this obstacle are then varied and the interfacial exchange rates investigated. Next, to evaluate the interaction of flow structures between obstacles, a second obstacle is introduced, separated by a varied distance. Finally, the shape of these obstacles is modified to create different wave forms. Each of these interfacial forms and obstacles is shown to create different flow structures adjacent to the surface which alter the mass, momentum, and energy conditions at the interface. These changes will enhance the exchange rate in locations where higher velocity gradients and more mixing with the main flow develop, but will reduce the exchange rate in locations where low velocity gradients and limited mixing with the main flow occur.
Molecular characterization, purification, and antioxidant activity of recombinant superoxide dismutase from the Pacific abalone Haliotis discus hannai Ino
Authors: Qiao Kun , Fang Chunhua , Chen Bei , Liu Zhiyu , Pan Nan , Peng Hui , Hao Hua , Xu Min , Wu Jingna , Liu Shuji 
Published: July 2020

Abstract
Superoxide dismutase (SOD) is an acidic metalloenzyme that scavenges free radicals produced by endogenous and exogenous substances. In the present study, the tissue distribution of the superoxide dismutase HdhCu/Zn-SOD was investigated in Haliotis discus hannai Ino. The expression profile after lipopolysaccharide (LPS) challenge was determined using quantitative real-time polymerase chain reaction (qPCR). To study the antioxidant activity of a recombinant HdhCu/Zn-SOD protein, the HdhCu/Zn-SOD gene was cloned into the pPIC9K vector and transformed into the Pichia pastoris GS115 strain by electroporation. After induction by methanol, the recombinant product was purified using immobilized metal affinity chromatography and confirmed using mass spectrometry. The optimal expression conditions were determined to be incubation with 0.5% methanol at pH 6.0, resulting in a stable expressed product with the molecular weight of approximately 17 kDa and 21 kDa. The enzymatic activity of HdhCu/Zn-SOD consistently increased with increasing Cu2+ concentrations and showed good thermal stability. Recombinant HdhCu/Zn-SOD showed a strong ability to scavenge superoxide anions and hydroxyl radicals and protected L929 cells against the toxicity caused by H2O2 through its in vitro antioxidant activity. The heterologous expression of HdhCu/Zn-SOD in P. pastoris and the antioxidant activity of this enzyme are reported for the first time.

Graphic abstract
Environmental risk assessment of pharmaceuticals at a seasonal holiday destination in the largest freshwater shallow lake in Central Europe
Authors: Molnar Eva , Maasz Gabor , Pirger Zsolt 
Published: July 2020

AbstractThe presence of pharmacologically active compounds (PhACs) in surface waters poses an environmental risk of chronic exposure to nontarget organisms, which is a well-established and serious concern worldwide. Our aim was to determine the temporal changes in ecological risk quotient (RQ) based on the concentrations of 42 PhACs from six sampling sites on seven sampling dates in the water of a freshwater lake in Central Europe preferentially visited by tourists. Our hypothesis was that the environmental risk increases during the summer holiday season due to the influence of tourists. Different experimental toxicological threshold concentrations and seasonal measured environmental concentrations of 16 PhACs were applied to ecological risk assessment. RQs of 4 dominant PhACs (diclofenac, estrone [E1], estradiol [E2], and caffeine) indicated high ecological risk (RQ > 1) for freshwater ecosystems. Additionally, our results confirmed the assumptions that the high tourist season had a significant impact on the calculated RQ; however, these results are mainly due to the concentration and temporal change of particular PhACs, including diclofenac (5.3-419.4 ng/L), E1 (0.1-5.5 ng/L), and E2 (0.1-19.6 ng/L). The seasonal dependent highest RQs changed as follows: 9.80 (June 2017; E2), 1.23 (August 2017; E1), 0.43 (November 2017; E1), 0.51 (April 2018; E1), 5.58 (June 2018, diclofenac), 39.50 (August 2018; diclofenac), and 30.60 (October 2018; diclofenac).
A Defence of the Control Principle
Authors: Sand Martin 
Published: July 2020

AbstractThe nexus of the moral luck debate is the control principle, which says that people are responsible only for things within their control. In this paper, I will first argue that the control principle should be restrained to blameworthiness, because responsibility is too wide a concept to square with control. Many deniers of moral luck appeal to the intuitiveness of the control principle. Defenders of moral luck do not share this intuition and demand a stronger defence of the control principle. I will establish a defence of the control principle based on the value of simplicity for selecting a theory of blameworthiness. A simpler theory of blameworthiness is more likely to be true, and not being falsely judged blameworthy is desirable. I will conclude that simplicity advices the acceptance of the control principle over other theories of blameworthiness that embrace factors beyond control.
State-of-the-Art Review on Responses of RC Structures Subjected to Lateral Impact Loads
Authors: Zhang Chunwei , Gholipour Gholamreza , Mousavi Asma Alsadat 
Published: July 2020

AbstractReinforced concrete structures and structural members used in strategic infrastructures such as highway bridges, high-rise buildings, etc. are inherently subjected to lateral impact loads arising from the collision of vehicles, vessels, falling rocks, and rigid objects having different impact geometries, weights, and velocities. Due to the brittle nature of concrete materials, both localized and overall failure modes are very likely to occur in concrete structures under dynamic and impulsive loads. Hence, many attempts have been carried out in the literature to recognize the failure behaviors and to assess the vulnerability of concrete structure under lateral impact loads. This paper presents a comprehensive state-of-the-art review on the responses and failure behaviors of various types of concrete structures and structural members subjected to lateral impact loads based on analytical, numerical, and experimental studies carried out by the previous research works. In addition, the influences of various structural- and load-related parameters on the impact resistance and failure behaviors of different concrete structures under lateral impact loads are reviewed.
Spatial Creaming and Parking?: the Case of the UK Work Programme
Authors: Whitworth A. 
Published: July 2020

AbstractPublic policies are inherently spatial in nature yet their geographical dimensions remain frequently underdeveloped and marginalised in policy practice and scholarship. This paper reflects critically on these common spatial blind spots, using as its case study example the UK’s Work Programme employment support policy. Whilstsocial‘creaming’ (i.e. deliberate prioritisation) and ‘parking’ (i.e. deliberate neglect) by providers of differently placed service users within public policies is widely acknowledged and researched, this paper introduces to the literature equivalent but neglected risks aroundspatialcreaming and parking of differently positioned local areas. The paper’s framing identifies that the Work Programme’s particular treatment of place exposes areas to high risks of spatial creaming and parking. Building on these critical spatial foundations, the paper moves on to present sophisticated statistical analyses of official and comprehensive Work Programme data. These original analyses demonstrate systematic spatial inequality in outcomes and financial resource that are at the expense of already more deprived geographies and that are consistent with our spatial creaming and parking hypotheses. The paper highlights the need to consider more fully the role of place within public policy practice and scholarship.