bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whiteness and School Shootings: Theorization toward a More Critical School Social Work
Authors: Gregory Joshua R 
Published: May 2020

Abstract
In the United States, school shootings have become an increasingly prevalent and publicly salient social problem. School social workers play a central role in developing understanding of their etiology and intervening to prevent their further occurrence. Even though nearly all school shootings are committed by white students, no etiological theory has contemplated the possibility that whiteness contributes in any meaningful way to the perpetration of school shootings. Popular theories suggest that gun availability, mental illness, and bullying bear some relationship to school shootings; however, levels of gun availability, mental illness prevalence, and bullying victimization do not differ substantially between whites and non-whites, indicating that these factors might account for school shootings within, but not between, races. The present article takes up the task of beginning to theorize the relationship between whiteness and school shootings, exploring the likelihood that whiteness acts as a moderator, leading whites, but not non-whites, to commit school shootings in response to similar antecedents. This novel theorization provides an opening for school social workers to more critically interrogate whiteness not as an individual trait, but as a structural phenomenon that influences not only the etiology of school shootings, but schools and educational processes more broadly.
Mid-term outcomes with the use of extracorporeal membrane oxygenation for cardiopulmonary failure secondary to massive pulmonary embolism
Authors: Sertic Federico , Diagne Dieynaba , Chavez Lexy , Richards Thomas , Berg Ashley , Acker Michael , Giri Jay S , Szeto Wilson Y , Khandhar Sameer , Gutsche Jacob , Pugliese Steven , Fiorilli Paul , Rame Eduardo , Bermudez Christian 
Published: May 2020

Abstract

OBJECTIVES

There has been increasing interest in using extracorporeal membrane oxygenation (ECMO) to rescue patients with pulmonary embolism (PE) in the advanced stages of respiratory or haemodynamic decompensation. We examined mid-term outcomes and risk factors for in-hospital mortality.

METHODS
We conducted a retrospective study of 36 patients who required ECMO placement (32 veno-arterial ECMO, 4 veno-venous) following acute PE. Survival curves were estimated using the Kaplan–Meier method. Risk factors for in-hospital mortality were assessed by logistic regression analysis. Functional status and quality of life were assessed by phone questionnaire.

RESULTS
Overall survival to hospital discharge was 44.4% (16/36). Two-year survival conditional to discharge was 94% (15/16). Two-year survival after veno-arterial ECMO was 39% (13/32). In patients supported with veno-venous ECMO, survival to discharge was 50%, and both patients were alive at follow-up. In univariable analysis, a history of recent surgery (P = 0.064), low left ventricular ejection fraction (P = 0.029), right ventricular dysfunction ≥ moderate at weaning (P = 0.083), on-going cardiopulmonary resuscitation at ECMO placement (P = 0.053) and elevated lactate at weaning (P = 0.002) were risk factors for in-hospital mortality. In multivariable analysis, recent surgery (P = 0.018) and low left ventricular ejection fraction at weaning (P = 0.013) were independent factors associated with in-hospital mortality. At a median follow-up of 23 months, 10 patients responded to our phone survey; all had acceptable functional status and quality of life.

CONCLUSIONS
Massive acute PE requiring ECMO support is associated with high early mortality, but patients surviving to hospital discharge have excellent mid-term outcomes with acceptable functional status and quality of life. ECMO can provide a stable platform to administer other intervention with the potential to improve outcomes. Risk factors for in-hospital mortality after PE and veno-arterial ECMO support were identified.
A randomized controlled trial of dapagliflozin on left ventricular hypertrophy in people with type two diabetes: the DAPA-LVH trial
Authors: Brown Alexander J M , Gandy Stephen , McCrimmon Rory , Houston John Graeme , Struthers Allan D , Lang Chim C 
Published: May 2020

Abstract

Aim
We tested the hypothesis that dapagliflozin may regress left ventricular hypertrophy (LVH) in people with type 2 diabetes (T2D).

Methods and results
We randomly assigned 66 people (mean age 67 ± 7 years, 38 males) with T2D, LVH, and controlled blood pressure (BP) to receive dapagliflozin 10 mg once daily or placebo for 12 months. Primary endpoint was change in absolute left ventricular mass (LVM), assessed by cardiac magnetic resonance imaging. In the intention-to-treat analysis, dapagliflozin significantly reduced LVM compared with placebo with an absolute mean change of −2.82g [95% confidence interval (CI): −5.13 to −0.51, P = 0.018]. Additional sensitivity analysis adjusting for baseline LVM, baseline BP, weight, and systolic BP change showed the LVM change to remain statistically significant (mean change −2.92g; 95% CI: −5.45 to −0.38, P = 0.025). Dapagliflozin significantly reduced pre-specified secondary endpoints including ambulatory 24-h systolic BP (P = 0.012), nocturnal systolic BP (P = 0.017), body weight (P &lt; 0.001), visceral adipose tissue (VAT) (P &lt; 0.001), subcutaneous adipose tissue (SCAT) (P = 0.001), insulin resistance, Homeostatic Model Assessment of Insulin Resistance (P = 0.017), and high-sensitivity C-reactive protein (hsCRP) (P = 0.049).

Conclusion
Dapagliflozin treatment significantly reduced LVM in people with T2D and LVH. This reduction in LVM was accompanied by reductions in systolic BP, body weight, visceral and SCAT, insulin resistance, and hsCRP. The regression of LVM suggests dapagliflozin can initiate reverse remodelling and changes in left ventricular structure that may partly contribute to the cardio-protective effects of dapagliflozin.

ClinicalTrials.gov Identifier
NCT02956811
Identifying patients who could benefit from palliative care by making use of the general practice information system: the Surprise Question versus the SPICT
Authors: van Wijmen Matthijs P S , Schweitzer Bart P M , Pasman H R , Onwuteaka-Philipsen Bregje D 
Published: May 2020

Abstract

Objective
We compared the performance of two tools to help general practitioners (GPs) identify patients in need of palliative care: the Surprise Question (SQ) and the Supportive and Palliative Care Indicators Tool (SPICT).

Methods
Prospective cohort study in two general practices in the Netherlands with a size of 3640 patients. At the start of the study the GPs selected patients by heart using the SQ. The SPICT was translated into a digital search in electronic patient records. The GPs then selected patients from the list thus created. Afterwards the GPs were interviewed about their experiences. The following year a record was kept of all the patients deceased in both practices. We analysed the characteristics of the patients selected and the deceased. We calculated the performance characteristics concerning predicting 1-year mortality.

Results
The sensitivity of the SQ was 50%, of the SPICT 57%; the specificity 99% and 98%. When analysing the deceased (n = 36), 10 died relatively suddenly and arguably could not be identified. Leaving out these 10, the sensitivity of the SQ became 69%, of the SPICT 81%. The GPs found the performance of the digital search quite time consuming.

Conclusion
The SPICT seems to be better in identifying patients in need of palliative care than the SQ. It is also more time consuming than the SQ. However, as the digital search can be performed more easily after it has been done for the first time, initial investments can repay themselves.
Terrorists as Rebels: Territorial Goals, Oil Resources, and Civil War Onset in Terrorist Campaigns
Authors: Ghatak Sambuddha , Karakaya Suveyda 
Published: May 2020

AbstractRecent studies show terrorist organizations that target only civilians almost always fail to achieve their ultimate objectives. On the contrary, groups that target combatants and civilians have better chances of success. Yet, most terrorist organizations do not directly target the state. When terrorist organizations shift their strategy from purely terrorist acts to confrontation against the target state, we may see a transition from terrorism to civil war. A terrorist organization's decision to engage in civil war largely depends on the organization's ability to alleviate the collective action problem. We argue terrorist groups with a territorial goal and groups operating in oil-rich countries are more likely to engage in civil war. The desire to gain a separate homeland is a powerful motivator to overcome the collective action problem. Terrorist organizations that operate in oil-rich countries are more likely to resort to civil war because oil dependence has the potential to increase grievances, which motivate rebellion, and resources provide a means of financing rebellion, while weakening target state institutions. Our findings confirm the existence of a territorial goal and availability of oil resources trigger transition from terrorism to civil war.
Wisdom Once Gained Is Not Easily Lost: Implicit Theories About Wisdom and Age-Related Cognitive Declines
Authors: Barber Sarah J , Kireeva Dina , Seliger Jordan , Jayawickreme Eranda 
Published: May 2020

Abstract

Background and Objectives
Most people agree that cognitive capabilities are an integral component of wisdom and its development. However, a question that has received less attention is whether people view maintaining cognitive capabilities as a necessary prerequisite for maintaining wisdom.

Research Design and Methods
This study used a mixed-methods approach to evaluate people’s views about the relationship between age-related cognitive declines, Alzheimer’s disease (AD), and wisdom. Our final sample of 1,519 adults ranged in age from 18 to 86.

Results
The majority of participants stated that wisdom could be present even in people with significant age-related cognitive declines or with AD. In the qualitative responses, common justifications for this were (a) that even people with severe AD can still exhibit wise behaviors during lucid moments, (b) that wisdom is an immutable characteristic that is impossible to lose, and (c) that wisdom maintenance and cognitive capability maintenance are separate constructs.

Discussion and Implications
Although prior research has examined implicit theories about the role of cognition in the development of wisdom, this is the first study to examine implicit theories about whether cognitive declines lead to wisdom declines. The results suggest that most people hold essentialist beliefs about wisdom, viewing it as a fixed and unchangeable trait rather than as a malleable skill.
How glycosylation affects glycosylation: the role of N-glycans in glycosyltransferase activity
Authors: Mikolajczyk Krzysztof , Kaczmarek Radoslaw , Czerwinski Marcin 
Published: May 2020

AbstractN-glycosylation is one of the most important posttranslational modifications of proteins. It plays important roles in the biogenesis and functions of proteins by influencing their folding, intracellular localization, stability and solubility. N-glycans are synthesized by glycosyltransferases, a complex group of ubiquitous enzymes that occur in most kingdoms of life. A growing body of evidence shows that N-glycans may influence processing and functions of glycosyltransferases, including their secretion, stability and substrate/acceptor affinity. Changes in these properties may have a profound impact on glycosyltransferase activity. Indeed, some glycosyltransferases have to be glycosylated themselves for full activity. N-glycans and glycosyltransferases play roles in the pathogenesis of many diseases (including cancers), so studies on glycosyltransferases may contribute to the development of new therapy methods and novel glycoengineered enzymes with improved properties. In this review, we focus on the role of N-glycosylation in the activity of glycosyltransferases and attempt to summarize all available data about this phenomenon.
Black PRAISE: engaging Black congregations to strengthen critical awareness of HIV affecting Black Canadian communities
Authors: Husbands Winston , Kerr Jelani , Calzavara Liviana , Tharao Wangari , Greenspan Nicole , Muchenje-Marisa Marvelous , Luyombya Henry , Nakamwa Joanita , Arnold Keresa , Nakiweewa Susan , Browne Orville 
Published: May 2020

Summary
In Canada, HIV disproportionately affects Black communities. Though Black faith leaders play an influential role engaging Black communities around social care and social justice, their response to HIV has been somewhat muted. Black PRAISE is a novel intervention for Black churches to strengthen congregants’ critical awareness of HIV affecting Black communities. A multi-stakeholder team developed and tested the intervention in 2016 − 17 among six churches in the province of Ontario, where more than half of Black Canadians reside, using a community-based participatory approach. Specifically, the intervention aimed to strengthen how congregants understand HIV among Black communities and reduce their level of stigma toward people living with HIV. We addressed critical awareness among the participating congregations through (i) disseminating a booklet with validated information that promoted critical health literacy related to HIV; (ii) enabling pastors to deliver a sermon on love, compassion and social justice; and (iii) developing and screening a short film that featured Black Canadians discussing their experiences of HIV-related stigma. We assessed changes in knowledge and stigma by surveying congregants (N = 173) at baseline and two follow-ups using validated instruments and other measures. Through Black PRAISE, congregants significantly increased their HIV-related knowledge; moreover, exposure to all the intervention components was associated with a significantly reduced level of stigma. A likely strategic outcome of Black PRAISE is that churches are empowered to help strengthen Black people’s community-based response to HIV and join efforts to eliminate the structural conditions that increase Black people’s vulnerability to HIV.
Innovation–diffusion, the economy and contemporary challenges: a comment
Authors: Fagerberg Jan , Verspagen Bart 
Published: May 2020

AbstractAccording to Christopher Freeman technological revolutions play a key role in capitalist development. In this article, we ask to what extent more recent developments are consistent with the perspective advanced by Freeman. We focus on two issues in particular, the climate challenge and what has been dubbed “A Fourth Industrial Revolution” that is, advances in artificial intelligence and the proliferation of the internet of things.
A Peptide-Based Magnetic Chemiluminescence Enzyme Immunoassay for Serological Diagnosis of Coronavirus Disease 2019
Authors: Cai Xue-fei , Chen Juan , li Hu Jie- , Long Quan-xin , Deng Hai-jun , Liu Ping , Fan Kai , Liao Pu , Liu Bei-zhong , Wu Gui-cheng , Chen Yao-kai , Li Zhi-jie , Wang Kun , Zhang Xiao-li , Tian Wen-guang , Xiang Jiang-lin , Du Hong-xin , Wang Jing , Hu Yuan , Tang Ni , Lin Yong , Ren Ji-hua , Huang Lu-yi , Wei Jie , Gan Chun-yang , Chen Yan-meng , Gao Qing-zhu , Chen A-mei , He Chang-long , Wang Dao-Xin , Hu Peng , Zhou Fa-Chun , Huang Ai-long , Wang De-qiang 
Published: May 2020

Abstract

Background
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel β-coronavirus, causes severe pneumonia and has spread throughout the globe rapidly. The disease associated with SARS-CoV-2 infection is named coronavirus disease 2019 (COVID-19). To date, real-time reverse-transcription polymerase chain reaction (RT-PCR) is the only test able to confirm this infection. However, the accuracy of RT-PCR depends on several factors; variations in these factors might significantly lower the sensitivity of detection.

Methods
In this study, we developed a peptide-based luminescent immunoassay that detected immunoglobulin (Ig)G and IgM. The assay cutoff value was determined by evaluating the sera from healthy and infected patients for pathogens other than SARS-CoV-2.

Results
To evaluate assay performance, we detected IgG and IgM in the sera from confirmed patients. The positive rate of IgG and IgM was 71.4% and 57.2%, respectively.

Conclusions
Therefore, combining our immunoassay with real-time RT-PCR might enhance the diagnostic accuracy of COVID-19.
Life cycles of the rhizocephalan Boschmaella japonica Deichmann & Høeg, 1990 (Cirripedia: Chthamalophilidae) and its host barnacle Chthamalus challengeri Hoek, 1883 (Cirripedia: Chthamalidae)
Authors: Yabuta Miku , Høeg Jens T , Yamato Shigeyuki , Yusa Yoichi 
Published: May 2020

Abstract
Although parasitic castration is widespread among rhizocephalan barnacles, Boschmaella japonica Deichmann & Høeg, 1990 does not completely sterilise the host barnacle Chthamalus challengeri Hoek, 1883. As little information is available on the relationships with the host in “barnacle-infesting parasitic barnacles” (family Chthamalophilidae), we studied the life cycles of both B. japonica and C. challengeri and the effects of the parasite on the host reproduction. Specimens of C. challengeri were collected from an upper intertidal shore at Shirahama, Wakayama, western Japan from April 2017 to September 2018 at 1–3 mo intervals. We recorded the body size, number of eggs, egg volume, and the presence of the parasite for each host. Moreover, settlement and growth of C. challengeri were followed in two fixed quadrats. Chthamalus challengeri brooded from February to June. The prevalence of B. japonica was high (often exceeded 10%) from April to July, and was rarely observed from September to next spring. The life cycle of the parasite matched well with that of the host. The parasite reduced the host’s brooding rate and brood size, to the extent that no hosts brooded in 2018.
Environmental DNA reveals cryptic diversity within the subterranean amphipod genus Pseudocrangonyx Akatsuka & Komai, 1922 (Amphipoda: Crangonyctoidea: Pseudocrangonyctidae) from central Japan
Authors: Yonezawa Satoru , Nakano Takafumi , Nakahama Naoyuki , Tomikawa Ko , Isagi Yuji 
Published: May 2020

Abstract
An environmental DNA (eDNA) detection method confirms the presence of the subterranean amphipod genus PseudocrangonyxAkatsuka & Komai, 1922 in the city of Kyoto, Honshu, Japan for the first time in more than 90 years. Phylogenetic trees using partial sequences of the 16S rRNA gene of eDNA samples from Kyoto and specimens collected from various locations in Japan and Korea highlight that two genetically distinct taxonomic units inhabit Kyoto’s subterranean environments. Results reveal that the ranges of distinct phylogroups of Pseudocrangonyx widely overlap with each other around Lake Biwa in central western Honshu. The eDNA results increase our understanding of the species richness and complicated evolutionary history of these stygobitic amphipods.
2D investigation of water permeability in hydrate-bearing sediment with coexisting hydrate growth habits
Authors: He Gaofeng , Luo Xianqi , Shakya Chandan 
Published: May 2020

AbstractPermeability variation in the presence of hydrates plays an important role in hydrate dissociation and may lead to extraction issues. Therefore, a wide range of pore-scale studies considering the hydrate growth habit have been conducted by various researchers. Here, we use microscopic training images of hydrate-bearing sediment to replicate the micromorphology of hydrates and coexisting hydrate growth habits (pore filling and coating) into 2D reconstruction models by multiple point statistics (MPS). Accounting for the geometric differences between each realisation and the different ratios between coating hydrate and pore-filling hydrate, permeability simulation is performed by the lattice Boltzmann Method (LBM). Results show that subtle geometric differences of hydrates may result in great changes in permeability for a given hydrate saturation for the same hydrate growth habit. The Kozeny–Carman model for single hydrate growth habit can also be used for the hydrate-bearing sediment with coexisting hydrate growth habits if the ratio of these two hydrate saturations is about 4, where the effect of coating or pore-filling hydrate can be neglected. This reconstruction model agrees well with experimental results and can be easily implemented in reservoir simulators for complex hydrate distributions.
Consecutive single-institution case series of primary central nervous system lymphoma treated by R-MPV or high-dose methotrexate monotherapy
Authors: Sasaki Nobuyoshi , Kobayashi Keiichi , Saito Kuniaki , Shimizu Saki , Suzuki Kaori , Lee Jeunghun , Yamagishi Yuki , Shibahara Junji , Takayama Nobuyuki , Shiokawa Yoshiaki , Nagane Motoo 
Published: May 2020

Abstract

Objective
The optimal regimen for use of high dose-methotrexate-based chemotherapy in primary central nervous system lymphoma is still under debate. We conducted a retrospective study to evaluate the treatment outcome of a combination immunochemotherapy consisting of rituximab, methotrexate, procarbazine and vincristine followed by with or without whole brain radiotherapy and consolidation cytarabine, in comparison with high dose-methotrexate monotherapy followed by full dose whole brain radiotherapy.

Methods
Newly diagnosed primary central nervous system lymphoma patients treated with either rituximab, methotrexate, procarbazine and vincristine or high dose-methotrexate in Kyorin University Hospital were identified, and the response rates and survival were compared. Toxicities, post-treatment transition of Mini-Mental State Examination, Karnofsky performance status score, Fazekas scale and prognostic factors were analysed in the rituximab, methotrexate, procarbazine and vincristine group.

Results
Ninety-five patients treated with rituximab, methotrexate, procarbazine and vincristine (n = 39) or high dose-methotrexate (n = 56) were analysed. The complete response/complete response unconfirmed rate was significantly higher in the rituximab, methotrexate, procarbazine and vincristine group (74.4 vs. 15.4%, P &lt; 0.001). Accordingly, both median progression-free survival and overall survival were significantly longer in the rituximab, methotrexate, procarbazine and vincristine group (median progression-free survival: unreached vs. 14.75 months, P &lt; 0.001) (median overall survival: unreached vs. 63.15 months, P = 0.005). Although the rate of grade 3/4 hematologic toxicities was high both during rituximab, methotrexate, procarbazine and vincristine and consolidation cytarabine, the rate of grade 3/4 infections was low, and no treatment related deaths were observed. Deterioration in Karnofsky performance status or Mini-Mental State Examination was rare, except on disease recurrence. Although whole brain radiotherapy was associated with Fazekas scale deterioration, its association with Karnofsky performance status or Mini-Mental State Examination deterioration was not significant.

Conclusions
Rituximab, methotrexate, procarbazine and vincristine was apparently promising in comparison with high dose-methotrexate monotherapy with manageable toxicity in this retrospective study, and further investigation is warranted.
Parotid adenocarcinoma metastasis to the breast: a case report
Authors: Smith Brandon M , Azouz Vitali , Liu Louisa , Williams Gary 
Published: May 2020

AbstractMetastatic salivary gland tumors are rare clinical entities of the head and neck. Parotid gland carcinoma with distant metastases heralds a poor prognosis with a median survival of 4.3–7.3 months. The lungs, long bones, liver and brain are the most common sites of metastasis for parotid gland cancer, along with a few reported cases describing metastasis to the ileum, spleen and iliac crest. We present the first case to our knowledge of parotid adenocarcinoma metastasis to the breast.