bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Review of Methods for the Geometric Post-Processing of Topology Optimized Models
Authors: Subedi Subodh C. , Verma Chaman Singh , Suresh Krishnan 
Published: July 2020

Abstract
Topology optimization (TO) has rapidly evolved from an academic exercise into an exciting discipline with numerous industrial applications. Various TO algorithms have been established, and several commercial TO software packages are now available. However, a major challenge in TO is the post-processing of the optimized models for downstream applications. Typically, optimal topologies generated by TO are faceted (triangulated) models, extracted from an underlying finite element mesh. These triangulated models are dense, poor quality, and lack feature/parametric control. This poses serious challenges to downstream applications such as prototyping/testing, design validation, and design exploration. One strategy to address this issue is to directly impose downstream requirements as constraints in the TO algorithm. However, this not only restricts the design space, it may even lead to TO failure. Separation of post-processing from TO is more robust and flexible. The objective of this paper is to provide a critical review of various post-processing methods and categorize them based both on targeted applications and underlying strategies. The paper concludes with unresolved challenges and future work.
How young children learn independent asthma self-management: a qualitative study in Malaysia
Authors: Ramdzan Siti Nurkamilla , Khoo Ee Ming , Liew Su May , Cunningham Steven , Kendall Marilyn , Sukri Nursyuhada , Salim Hani , Suhaimi Julia , Lee Ping Yein , Cheong Ai Theng , Hussein Norita , Hanafi Nik Sherina , Mohd Ahad Azainorsuzila , Pinnock Hilary 
Published: July 2020

ObjectiveWe aimed to explore the views of Malaysian children with asthma and their parents to enhance understanding of early influences on development of self-management skills.DesignThis is a qualitative study conducted among children with asthma and their parents. We used purposive sampling and conducted focus groups and interviews using a semi-structured topic guide in the participants’ preferred language. All interviews were audio-recorded, transcribed verbatim, entered into NVivo and analysed using a grounded theory approach.SettingsWe identified children aged 7–12 years with parent-reported, physician-diagnosed asthma from seven suburban primary schools in Malaysia. Focus groups and interviews were conducted either at schools or a health centre.ResultsNinety-nine participants (46 caregivers, 53 children) contributed to 24 focus groups and 6 individual interviews. Children mirrored their parents’ management of asthma but, in parallel, learnt and gained confidence to independently self-manage asthma from their own experiences and self-experimentation. Increasing independence was more apparent in children aged 10 years and above. Cultural norms and beliefs influenced children’s independence to self-manage asthma either directly or indirectly through their social network. External influences, for example, support from school and healthcare, also played a role in the transition.ConclusionChildren learnt the skills to self-manage asthma as early as 7 years old with growing independence from the age of 10 years. Healthcare professionals should use child-centred approach and involve schools to facilitate asthma self-management and support a smooth transition to independent self-management.Trial registration numberMalaysian National Medical Research Register (NMRR-15-1242-26898).
Prior surgical uterine evacuation of pregnancy and infertility: protocol for systematic review and meta-analysis
Authors: Tu Pengcheng , Pei Kaiyan 
Published: July 2020

IntroductionPrior surgical uterine evacuation is associated with an increased risk of infertility. However, findings are inconsistent, highlighting the need for a clear consensus on the effect of prior surgical uterine evacuation on the risk of infertility. Therefore, the aim of this systematic review and meta-analysis is to summarise the available evidence examining the association between prior surgical uterine evacuation and the risk of infertility.Methods and analysisA systematic search of electronic databases (ie, PubMed, Scopus, ClinicalTrials.gov, EMBASE and ScienceDirect) will be conducted since their inception until October 2019 with no limit for language using a detailed prespecified search strategy. Both the authors will independently screen titles and abstracts and select full-text articles, perform data extraction and appraise the quality of included studies using a bias classification tool. Meta-analyses will be performed to calculate the overall pooled estimates using the generic inverse variance method. This systematic review and meta-analysis will follow the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) guidelines.Ethics and disseminationGiven that this is a protocol based on published data, there is no requirement for ethics approval. It is anticipated that the dissemination of results will be reported according to the PRISMA statement. The results will be published in peer-reviewed journals and presented at scientific conferences.PROSPERO registration numberCRD42019117266.
Prevalence and predictors of road crash involvement among medical doctors in Malaysia: a cross-sectional study protocol
Authors: Rashid Aneesa Abdul , Devaraj Navin Kumar , Mohd Yusof Halidah , Mustapha Fauzan , Wong Shaw Voon , Ismail Ahmad Filza , Ismail Khairil Idham , Qureshi Ahmad Munir , Nordin Rusli Bin 
Published: July 2020

IntroductionMedical doctors are often subjected to long working hours with minimal rest in between the shifts. This has led to many fatal and non-fatal road crash involvement (RCI). This study aims to determine the prevalence and predictors of RCI among medical doctors in Malaysia.Methods and analysisThis is a cross-sectional study among 375 Malaysian medical doctors who met the inclusion criteria. A predetermined self-administered questionnaires will be used to collect information regarding the sociodemographic, health status, workplace information, work commuting information, driving behaviour, history of RCI, fatigue, sleep quality, mental health status and work engagement. The questionnaires consist of the following instruments: (1) sociodemographic, health status, workplace information, work commuting information, driving behaviour and history of RCI; (2) Checklist of Individual Strength Questionnaire; (3) Pittsburgh Sleep Quality Index; (4) 21-item Depression Anxiety and Stress Scale; and (5) Utrecht's Work Engagement Scale. The data will be analysed using SPSS program V.24. Descriptive and inferential statistics will be used to determine the prevalence and predictors of RCI.Ethics and disseminationThis study protocol has received ethics approval from the Medical Research and Ethics Committee (MREC), Ministry of Health Malaysia (NMRR-18-3983-40609) and the Ethics Committee for Research Involving Human Subject, University Putra Malaysia (JKEUPM). Online written informed consent will be obtained from each study participant by the researchers. Results of the study will be disseminated through relevant journals and conferences.Trial registration numberNCT04243291.
Colles’ type distal radial fractures undergoing manipulation in the ED: a multicentre observational cohort study
Authors: Malik Hamza , Appelboam Andrew , Taylor Gordon 
Published: July 2020

BackgroundColles’ type fractures of the distal radius are one of the most commonly manipulated fractures in the ED. Local audit data suggest that a high proportion of these injuries undergo subsequent surgical fixation. If widespread, this could represent a potential burden on patients and the NHS worthy of further research. The aims of this study were to estimate the rate of surgical fixation of Colles’ type distal radial fractures after ED fracture manipulation and explore variations in their management in UK EDs.MethodsWe conducted a multicentre observational study in 16 EDs in the UK from 4 February 2019 to 31 March 2019. All adult patients with a Colles’ fracture who underwent fracture manipulation in the ED were included. Patients who could not be followed up and those with volar displaced fractures were excluded. We measured the rate of wrist fracture surgery at 6 weeks, patient demographics and variations in anaesthetic technique used.ResultsDuring the study period, 328 adult patients attended the participating EDs with a distal radial fracture. Of these, 83 patients underwent fracture manipulation in the ED and were eligible for the study. Their mean age (SD) was 65.3 (17.0) years, 84.3% were female and the most common method of anaesthesia used was haematoma block (38.6%). 34 (41.0%, 95 % CI 30.3 to 52.3) patients had subsequent surgical fixation of their fracture. Younger age was associated with higher rates of surgical fixation but ED anaesthetic technique did not affect the subsequent need for surgery in this sample.ConclusionSubsequent surgical fixation was carried out in 41% of patients who underwent manipulation of Colles’ type wrist fractures in this cohort. This merits further research and represents a potential target to rationalise repeat procedures.
Trends and predictors in all-cause and cause-specific mortality in diabetic and reference populations during 21 years of follow-up
Authors: Niskanen Leo , Partonen Timo , Auvinen Anssi , Haukka Jari 
Published: July 2020

BackgroundPatients with diabetes mellitus (DM) have a markedly higher overall mortality from coronary heart disease (CHD), as well as many other causes of death like cancer. Since diabetes is a multisystem disease, this fact together with the increased lifespan among individuals with diabetes may also lead to the emergence of other diabetes-related complications and ultimately to diversification of the causes of death.MethodsThe study population of this observational historic cohort study consisted of subjects with DM, who had purchased for at least one insulin prescription and/or one oral antidiabetic between January 1, 1997 and December 31, 2010 (N=199 354), and a reference population matched by age, sex and hospital district (N=199 354). Follow-up was continued until December 31, 2017. All-cause and cause-specific mortality (cancer, CHD and stroke) was analysed with Poisson and Cox’s regression. Associations between baseline medications and mortality were analysed using LASSO (Least Absolute Shrinkage and Selection Operator) models.ResultsThe mortality rates were significantly elevated among the patients with DM. However, the relative risk of all-cause mortality between the DM and reference populations tended to converge during the follow-up. The lowering trend was most apparent in CHD mortality. The difference between DM and reference populations in stroke mortality vanished with a later entrance to the follow-up period. There were a few differences between DM and no-DM groups with respect to how baseline medications were associated with mortality.ConclusionsThe gap between the mortality of patients with diabetes compared to subjects who are non-diabetic diminished markedly during the 21-year period. This was driven primarily by the reduced CHD mortality.
Phase I study of the 177Lu-DOTA0-Tyr3-Octreotate (lutathera) in combination with nivolumab in patients with neuroendocrine tumors of the lung
Authors: Kim Chul , Liu Stephen V , Subramaniam Deepa S , Torres Tisdrey , Loda Massimo , Esposito Giuseppe , Giaccone Giuseppe 
Published: July 2020

BackgroundLutathera is a 177Lutetium-labeled somatostatin analog approved for the treatment of gastroenteropancreatic neuroendocrine tumors (NETs). Somatostatin receptors are expressed in small cell lung cancer (SCLC). Nivolumab, an anti-PD-1 antibody, may act synergistically with lutathera to generate antitumor immunity. We conducted a phase I study of lutathera plus nivolumab in patients with advanced NETs of the lung.MethodsPatients with relapsed/refractory extensive-stage SCLC (ES-SCLC), non-progressing ES-SCLC after first-line platinum-based chemotherapy, or advanced grade I-II pulmonary NETs were eligible. The primary objective was to determine the recommended phase 2 dose (RP2D). The phase I portion followed a standard 3+3 design, assessing two dose levels (dose level 1: lutathera 3.7 GBq every 8 weeks for four doses with nivolumab 240 mg every 2 weeks; dose level 2: lutathera 7.4 GBq every 8 weeks for four doses with nivolumab 240 mg every 2 weeks).ResultsNine patients were enrolled (six ES-SCLC, two pulmonary atypical carcinoid, one high-grade pulmonary neuroendocrine carcinoma). No dose-limiting toxicities (DLTs) were observed at dose level 1. At dose level 2, one patient with refractory ES-SCLC developed a DLT (grade 3 rash). The most common treatment-related adverse events (TRAEs) were lymphopenia (n=7), thrombocytopenia (n=4), anemia (n=3), and nausea (n=3). The most common grade 3 TRAE was lymphopenia (n=4). Among the seven patients with measurable disease, one patient with ES-SCLC had a partial response. Two patients with pulmonary atypical carcinoid had stable disease lasting 6 months. The RP2D was dose level 2.ConclusionsLutathera plus nivolumab was well tolerated and showed signs of antitumor activity. This combination warrants further exploration.Trial registration numberNCT03325816
Traumatic haemothorax in a dog managed without surgery using a guidewire‐inserted chest tube and a single closed system for collection and administration of autotransfusion
Authors: Miller Victoria , Pigott Armi 
Published: July 2020

SUMMARYA dog with multiple stab wounds to the chest presented with haemorrhagic shock and respiratory compromise secondary to traumatic haemothorax. A kit to rapidly evacuate the pleural space and subsequently administer autotransfusion was devised with readily available supplies. The dog was managed successfully with wire‐inserted chest tubes and autotransfusion, did not proceed to surgery and had a rapid full recovery. The kit described creates a single closed collection and administration system for autotransfusion, is simple, inexpensive, made from readily available supplies and permits large volume effusions to be evacuated rapidly with fewer staff involved.
Hyperbolic ring based formulation for thermo field dynamics, quantum dissipation, entanglement, and holography
Authors: Cartas-Fuentevilla R. , Berra-Montiel J. , Meza-Aldama O. 
Published: July 2020

AbstractThe classical and quantum formulations for open systems related to dissipative dynamics are constructed on a complex hyperbolic ring, following universal symmetry principles, and considering the double thermal fields approach for modeling the system of interest, and the environment. The hyperbolic rotations are revealed as an underlying internal symmetry for the dissipative dynamics, and a chemical potential is identified as conjugate variable to the charge operator, and thus a grand partition function is constructed. As opposed to the standard scheme, there are not patologies associated with the existence of many unitarity inequivalent representations on the hyperbolic ring, since the whole of the dissipative quantum dynamics is realized by choosing only one representation of the field commutation relations. Entanglement entropy operators for the subsystem of interest and the environment, are constructed as a tool for study the entanglement generated from the dissipation. The holographic perspectives of our results are discussed.
Two tales of complex system analysis: MaxEnt and agent-based modeling
Authors: Yang Jangho , Carro Adrián 
Published: July 2020

AbstractOver the recent four decades, agent-based modeling and maximum entropy modeling have provided some of the most notable contributions applying concepts from complexity science to a broad range of problems in economics. In this paper, we argue that these two seemingly unrelated approaches can actually complement each other, providing a powerful conceptual/empirical tool for the analysis of complex economic problems. The maximum entropy approach is particularly well suited for an analytically rigorous study of the qualitative properties of systems in quasi-equilibrium. Agent-based modeling, unconstrained by either equilibrium or analytical tractability considerations, can provide a richer picture of the system under study by allowing for a wider choice of behavioral assumptions. In order to demonstrate the complementarity of these approaches, we use here two simple economic models based on maximum entropy principles – a quantal response social interaction model and a market feedback model –, for which we develop agent-based equivalent models. On the one hand, this allows us to highlight the potential of maximum entropy models for guiding the development of well-grounded, first-approximation agent-based models. On the other hand, we are also able to demonstrate the capabilities of agent-based models for tracking irreversible and out-of-equilibrium dynamics as well as for exploring the consequences of agent heterogeneity, thus fundamentally improving on the original maximum entropy model and potentially guiding its further extension.
The Rolling Corpus
Authors: Nati James 
Published: July 2020

Abstract
Drawing on insights from the field of Book History, the article draws out connections between the material aspects of the Qumran corpus on the one hand and textual pluriformity on the other, paying particular attention to the Serekh ha-Yaḥad. The article suggests that the large-scale pluriformity exhibited by texts such as the Serekh is best understood in light of certain material features particular to skin scrolls, and that opisthographs ought to be integrated into discussions of textual pluriformity. The article concludes by offering more general comments about the effects of the scroll on writing and reading practices in early Judaism.
L’actualité de Condorcet en Hongrie, 1986-2020. Témoignage d’une dix-huitiémiste fidèle aux Lumières
Authors: Ludassy Maria 
Published: July 2020

Résumé
Cette contribution est le témoignage d’une universitaire qui s’est appuyée dans ses cours comme dans ses publications sur les Lumières pour contester le bien-fondé du régime communiste en Hongrie. Elle analyse le sort fait à la philosophie du XVIIIe siècle dans la transition qui voit son pays basculer d’un régime communiste à un régime nationaliste fondé sur une mythologie hun-magyar, utilisée traditionnellement par l’extrême-droite hongroise. La pensée de Condorcet sert de repère pour s’orienter dans ces bouleversements et pour en faire émerger le sens politique.
Jovan Deretic lecteur de Dositej Obradovic : du marxisme au structuralisme. Un historien de la littérature en Serbie (1960-1970)1
Authors: Nikolić Nenad 
Published: July 2020

Résumé
Le présent travail retrace le parcours intellectuel, dans la Serbie communiste, de Jovan Deretic, grand historien de la littérature serbe. L’analyse se fonde sur ses diverses lectures de l’œuvre de Dositej Obradovic. Elle présente d’abord l’importance de ce dernier pour la culture serbe à l’époque des Lumières. Elle montre ensuite que les premières analyses de son œuvre par Deretic sont ancrées principalement dans le matérialisme dialectique. Dans une deuxième étape, Deretic se tourne vers le structuralisme néo-positiviste pour offrir une approche plus immanente de l’œuvre d’Obradovic. Il aboutit finalement à une prise de conscience des contradictions et des limites de l’analyse immanente tout autant que de l’interprétation idéologique d’une œuvre.
Mixing up the Senses: Sensory Substitution Is Not a Form of Artificially Induced Synaesthesia
Authors: Kirsch Louise P. , Job Xavier , Auvray Malika 
Published: July 2020

Abstract
Sensory Substitution Devices (SSDs) are typically used to restore functionality of a sensory modality that has been lost, like vision for the blind, by recruiting another sensory modality such as touch or audition. Sensory substitution has given rise to many debates in psychology, neuroscience and philosophy regarding the nature of experience when using SSDs. Questions first arose as to whether the experience of sensory substitution is represented by the substituted information, the substituting information, or a multisensory combination of the two. More recently, parallels have been drawn between sensory substitution and synaesthesia, a rare condition in which individuals involuntarily experience a percept in one sensory or cognitive pathway when another one is stimulated. Here, we explore the efficacy of understanding sensory substitution as a form of ‘artificial synaesthesia’. We identify several problems with previous suggestions for a link between these two phenomena. Furthermore, we find that sensory substitution does not fulfil the essential criteria that characterise synaesthesia. We conclude that sensory substitution and synaesthesia are independent of each other and thus, the ‘artificial synaesthesia’ view of sensory substitution should be rejected.
Dinamiche cultuali ad Assur in età arsacide: alcune osservazioni
Authors: Marcato Enrico 
Published: July 2020

Abstract
The massive Temenos of Assor and Serū (Assyrian Aššur and Šerūʾa) in Arsacid Ashur testifies to the cult of ancient Assyrian deities in this venerable, albeit peripheric, city in Northern Mesopotamia between the 1st and 3rd centuries AD. It is also well known that the temple of Assor and Serū proper, built exactly above the Neo-Assyrian temple of Aššur, has yielded several Aramaic inscriptions that provide substantial evidence for the continuity of some Assyrian cults, onomastic, and religious calendar. Thanks to the joint analysis of epigraphic and archaeological data from the temple, the present paper aims at highlighting some aspects of cultic practice, namely the regular presence of some individuals during solemn festivities.
The Influence of Verbal Semantics on Agreement Patterns in Arabic: the Role of Agenthood
Authors: D’Anna Luca 
Published: July 2020

Abstract
The present paper, based on a complete analysis of the Quranic text, investigates the influence of verbal semantics on agreement choices in Quranic Arabic. Building on the principle according to which, when a language shifts from a prevalently formal agreement system to a partially semantic one, conditions gain more importance (Fleischer, Rieken, Widmer 2015: 21), it focuses on the role of agenthood (or agency) in triggering syntactic agreement. The analysis of the data reveals that the occurrence of an action verb and of an agent subject favors syntactic agreement in the feminine plural, although not systematically. Passive verbs, copulas and state verbs, in which the subject is either a patient or an experiencer, on the other hand, strongly favor semantic agreement in the feminine singular. From this perspective, moreover, Quranic Arabic seems to represent a more innovative stage of the language when compared to pre-Islamic poetry, described in D’Anna (forth.).
Abel and Dan (2 Sam 20:18–19) in Textual Criticism, Tradition History, and Archaeology
Authors: de Hulster Izaak J. , Kauhanen Tuukka 
Published: July 2020

Abstract
The MT form of the saying of the wise woman in 2 Sam 20:18–19 presents multiple text-critical problems. Instead of “Let them inquire at Abel,” the LXX refers to “Abel and Dan.” The notion of the wise woman being “one of those who are peaceable and faithful in Israel” (NRSV) is grammatically difficult; the LXX reads differently: “what the faithful of Israel had established, had been abandoned.” This article seeks to bring textual criticism into discussion with an archaeological analysis, including a tradition-historical angle on the story, by: 1. Re-examining the textual evidence, with due consideration of the Septuagint; 2. Considering the archaeological findings of Iron Age sites at Tel Abel and Tel Dan; 3. Examining the textual and iconographic implications of the motif “woman on the wall;” and 4. Evaluating the plausibility of the historical settings implied in the story in light of the textual and archaeological evidence.