bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of SAPT(DFT) with meta-GGA functionals
Authors: Hapka Michał , Modrzejewski Marcin , Chałasiński Grzegorz , Szczęśniak Małgorzata M. 
Published: May 2020

AbstractThis work examines the suitability of meta-GGA functionals for symmetry-adapted perturbation theory (SAPT) calculations. The assessment is based on the term-by-term comparison with the benchmark SAPT variant based on coupled-cluster singles and doubles description of monomers, SAPT(CCSD). Testing systems include molecular complexes ranging from strong to weak and the He dimer. The following nonempirical meta-GGAs are examined: TPSS, revTPSS, MVS, SCAN, and SCAN0 with and without the asymptotic correction (AC) of the exchange-correlation potential. One range-separated meta-GGA functional, LC-PBETPSS, is also included. The AC-corrected pure meta-GGAs (with the exception of MVS) represent a definite progress in SAPT(DFT) compared to pure GGA, such as PBEAC, with their more consistent predictions of energy components. However, none of the meta-GGAs is better than the hybrid GGA approach SAPT(PBE0AC). The SAPT(DFT) electrostatic energy offers the most sensitive probe of the quality of the underlying DFT density. Both SCAN- and TPSS-based electrostatic energies agree with reference to within 5% or better which is an excellent result. We find that SCAN0 can be used in SAPT without the AC correction. The long-range corrected LC-PBETPSS is a reliable performer both for the components and total interaction energies.
Congruence between nursing students’ and patients’ views of student–patient relationships
Authors: Suikkala Arja , Koskinen Sanna , Katajisto Jouko , Leino-Kilpi Helena 
Published: May 2020

AbstractThe growing emphasis on learning with and from patients has shifted the focus from education and healthcare professionals to the student–patient relationship. The relationship between student and patient, with a supportive preceptor as a resource, can influence the progression and development of an authentic person-centred approach to care among students. The purpose of this study was to analyse the congruence between nursing students’ and patients’ views of their relationship during students’ clinical placement. The study compared data from cross-sectional matched cohort pairs of nursing students (n = 187) and patients (n = 187) in Finland. The data were collected between March 2015 and May 2016 using corresponding questionnaires and procedures in both cases. Both students’ and patients’ views were moderately or weakly congruent in terms of facilitative relationship, characterised as a mutually enriching relationship for both students and patients through dialogue. Patients, however, tended to see the relationship significantly more often as mechanistic, focusing on students learning practical skills, compared to students who saw the relationship more often as facilitative. Patients’ age and the reasons for care were the only background variables that predicted the congruence between students’ and patients’ views of their relationships. These findings suggest ways in which student–patient relationships can be made more meaningful in supporting learning in clinical education.
HER2-targeted therapy influences CTC status in metastatic breast cancer
Authors: Deutsch Thomas M. , Riethdorf Sabine , Fremd Carlo , Feisst Manuel , Nees Juliane , Fischer Chiara , Hartkopf Andreas D. , Pantel Klaus , Trumpp Andreas , Schütz Florian , Schneeweiss Andreas , Wallwiener Markus 
Published: May 2020

Abstract
Purpose
As an independent, negative-prognostic biomarker for progression-free survival (PFS) and overall survival (OS), circulating tumor cells (CTCs) constitute a promising component for developing a liquid biopsy for patients with metastatic breast cancer (MBC). The effects of HER2-targeted therapy such as trastuzumab, pertuzumab, T-DM1, and lapatinib on CTC status and longitudinal enumeration were assessed in this trial.

Methods
CTC status of 264 patients with MBC was analyzed prior to and after 4 weeks of a new line of palliative systemic therapy. CTCs were assessed using CellSearch®. Three groups were compared: patients with HER2-positive MBC receiving ongoing HER2-targeted therapy (n = 28), patients with de novo HER2-positive MBC and no HER2-targeted therapy in the last 12 months prior to enrollment and start of HER2-targeted therapy (n = 15), and patients with HER2-nonamplified disease and no HER2-targeted therapy (n = 212).

Results
Positive CTC status (≥ 5 CTC/7.5 ml blood) at enrollment was observed in the 3 groups for 17.9, 46.7, and 46.2% (p = 0.02) of patients, respectively. At least one CTC/7.5 ml was seen in 28.6, 53.3, and 67.0% (p < 0.001) of these patients. Furthermore, 3.6, 40.0, and 3.3% (p < 0.001) of the patients had at least one HER2-positive CTC. After 4 weeks of therapy 7.1, 0.0, and 31.1% (p = 0.001) of patients had still a positive CTC status (≥ 5 CTC/7.5 ml blood). At least one CTC/7.5 ml was still observed in 25.0, 20.0, and 50.5% (p = 0.004) of the patients. Furthermore, 7.1, 0.0, and 1.9% (p = 0.187) had at least one HER2-positive CTC. After 3 months of therapy, 35.7, 20.0, and 28.3% (p = 0.536) showed disease progression.

Conclusions
HER2-targeted therapy seems to reduce the overall CTC count in patients with MBC. This should be taken into account when CTC status is used as an indicator for aggressive or indolent metastatic tumor disease.
Conserving on the edge: genetic variation and structure in northern populations of the endangered plant Dracocephalum ruyschiana L. (Lamiaceae)
Authors: Kyrkjeeide Magni Olsen , Westergaard Kristine Bakke , Kleven Oddmund , Evju Marianne , Endrestøl Anders , Brandrud Marie Kristine , Stabbetorp Odd 
Published: May 2020

AbstractLoss of biodiversity is accelerating, including the loss of genetic diversity. Conservation of small, isolated populations may be important, as they can provide valuable contributions to overall genetic variation and long-term viability of species. Furthermore, such populations may play an essential role in adaptation to new environments following changes in e.g. land-use and climate. Dracocephalum ruyschiana is a threatened plant species throughout its European distribution, but 25% of the European populations are situated within Norway. Therefore, the species has its own action plan in Norway, which includes demographic monitoring. However, this monitoring does not cover genetic variation nor is the selection of monitored populations based on genetic differentiation, therefore this fundamental level of biodiversity is overlooked. We analyzed 43 sites using 96 SNPs developed for D. ruyschiana, to investigate whether the monitored populations cover the genetic variation and differentiation found within the Norwegian distribution. The results show structuring and differentiation between populations and indicate that there are at least four distinct genetic groups, of which only two are covered extensively by current demographic monitoring. We suggest that two sites representing the two other genetic groups should be included in the national monitoring program to better conserve the genetic variation found in the Norwegian population of D. ruyschiana. Overall, our results highlight the importance of an integrated, interdisciplinary framework to better monitor and conserve biodiversity at several levels.
Number of prior negative screening outcomes does not influence future risk of breast cancer
Authors: Lilleborge Marie , Falk Ragnhild S. , Hofvind Solveig 
Published: May 2020

AbstractWe questioned whether a history of negative screening outcomes could be used to predict breast cancer risk, and thus be used as a potential factor for stratification of mammographic screening. Data from the Norwegian population based breast cancer screening program, BreastScreen Norway, was used to estimate cumulative hazard rates for breast cancer by number of prior negative screening outcomes among participants from 1995 through 2016. We followed three age cohorts of women, who started screening at age 50–54, 55–59, and 60–64 years. Further, we estimated the absolute and relative risk of breast cancer by number of prior negative screening outcomes. The cumulative hazard curves were parallel for all numbers of negative screening outcomes for all age cohorts. The absolute risk of breast cancer increased with number of negative screening outcomes for the youngest age cohort. For the oldest age cohorts, the absolute risk was stable during the screening period and decreased thereafter. The number of negative screening outcomes was not associated with risk of breast cancer, adjusted for age, percent screening attendance and calendar years (HR 1.00, 95% CI 0.98–1.02). Our results suggest that the number of negative screening outcomes does not predict breast cancer risk among participants in BreastScreen Norway.
Robots responding to care needs? A multitasking care robot pursued for 25 years, available products offer simple entertainment and instrumental assistance
Authors: Van Aerschot Lina , Parviainen Jaana 
Published: May 2020

AbstractTwenty-five years ago, robotics guru Joseph Engelberger had a mission to motivate research teams all over the world to design the ‘Elderly Care Giver’, a multitasking personal robot assistant for everyday care needs in old age. In this article, we discuss how this vision of omnipotent care robots has influenced the design strategies of care robotics, the development of R&D initiatives and ethics research on use of care robots. Despite the expectations of robots revolutionizing care of older people, the role of robots in human care has remained marginal. The value of world trade in service robots, including care robots, is rather small. We argue that the implementation of robots in care is not primarily due to negative user attitudes or ethical problems, but to problems in R&D and manufacturing. The care robots currently available on the market are capable of simple, repetitive tasks or colloquial interaction. Thus far, also research on care robots is mostly conducted using imaginary scenarios or small-scale tests built up for research purposes. To develop useful and affordable robot solutions that are ethically, socially and ecologically sustainable, we suggest that robot initiatives should be evaluated within the framework of care ecosystems. This implies that attention has to be paid to the social, emotional and practical contexts in which care is given and received. Also, the political, economic and ecological realities of organizing care and producing technological commodities have to be acknowledged. It is time to openly discuss the drivers behind care robot initiatives to outline the bigger picture of organizing care under conditions of limited resources.
Comparative Analysis of Cone Resistances in Cone Penetration Test (CPTu) and Dynamic Probe Heavy Test (DPH)
Authors: Bagińska Irena 
Published: May 2020

AbstractThis paper presents a comparison of geotechnical soil testing with the use of Piezocone Penetration Test (CPTu) and Dynamic Probing Heavy (DPH) in a uniform coarse-grained medium located in southwest part of Poland. The soil medium was identified in detail. The interpretation of results included both grain-size analysis of samples from drillholes and soil behavior type results obtained from the Robertson nomograph (Soil behaviour type from the CPT: an update. In: 2nd international symposium on cone penetration testing, USA, 2010). Cone penetration resistances qc obtained in the static CPTu tests were compared with the results of dynamic probing N10H and of dynamic point resistance qd obtained in the dynamic DPH tests. The evaluation of soil density index was based on both dynamic DPH and static CPTu probing. The obtained results were analyzed and plotted in a form of graphs corresponding to the Eurocode 7 and other works describing coarse-grained soils.
Polycomb-like 2 regulates PRC2 components to affect proliferation in glioma cells
Authors: Wang Fei , Gao Yongying , Lv Ye , Wu Yanwei , Guo Yongzhen , Du Fang , Wang Shixiong , Yu Jiaxiang , Cao Xiangmei , Li P. Andy 
Published: May 2020

Abstract
Introduction
The Polycomb group (PcG) is an important family of transcriptional regulators that controls growth and tumorigenesis. The PcG mainly consists of two complexes, PRC1 and Polycomb Repressive Complex 2 (PRC2). Polycomb-like 2 (PCL2) is known to interact with the PRC2 protein. The role of PCL2 in the development and progression of glioma is unclear.

Methods
We use The Cancer Genome Atlas (TCGA) database to detect the expression of PCL2 in various tumors. 117 cases of clinical glioma (WHOI–IV) were collected, and PCL2 expression and localization were detected by immunohistochemical staining. Glioma cells U87/U251 were infected with overexpressed and interfered PCL2. CCK8 assay, colony formation assay, EdU method, cell cycle and apoptosis were used to detect cell proliferation and apoptosis. Western blot was used to detect the expression of PRC2-related core proteins. After DZNeP intervention, PRC2 protein expression was again measured to discuss the mechanism of PCL2 action.

Results
TCGA database results and immunohistochemical staining results suggest that PCL2 is highly expressed in gliomas. We found that the PCL2 gene promoted tumor cell proliferation, enhanced the colony formation ability, and increased S phase in the cell cycle. The overexpression of PCL2 upregulated the expression levels of EZH2 and EED (two core members of PRC2), decreased the expression of SUZ12, increased the level of H3K27 trimethylation (H3K27me3), H3K4 dimethylation (H3K4me2), and decreased H3K9 dimethylation (H3K9me2). The result after interfering with PCL2 was the opposite.

Conclusions
As an important accessory protein of PRC2, PCL2 can not only change the expression of PRC2 components, but also affect the expression level of Histone methylation. Therefore, PCL2 may be an important hub for regulating the synergy among PRC2 members. This study revealed PCL2 as a new target for tumor research and open up a new avenue for future research in glioma.
Riding on the Coat-Tails of Traditional Cultural Expressions
Authors: Olteanu Luminița 
Published: May 2020

AbstractMatters related to the protection of traditional cultural expressions (‘TCEs’) or expressions of folklore (‘EoFs’) are sensitive and intricate as a blend of legal, economic, philosophical and anthropological considerations jostle to capture their core features. This results in disparate views surrounding what should qualify as TCEs or EoFs, who should be considered their ‘owner’ (assuming that ownership per se is conceptually compatible with these items), which is the most appropriate legal protection regime and how broad their scope of protection should be. Drawing from these various accounts on TCEs, this article focuses on the interaction between TCEs and EoFs originating on the European continent and the European Union (‘EU’) trade mark legislation. Specifically, this article examines whether the limitations of the effects of trade mark rights and of the absolute grounds of refusal, as developed by the case law of the Court of Justice of the European Union, are effective in preserving the cohesion of TCEs. This article advances the thesis that registration of TCEs and EoFs as trade marks generates an imbalance between the rights of the trade mark owner and the defences available to others under the EU trade mark law framework. Furthermore, such an imbalance is likely to hinder the unfettered circulation of TCEs and undermine their original meaning. Lastly, in some cases, trade mark registration of TCEs contributes to their appropriation and misappropriation. The article concludes that,de lege ferenda, the direct exclusion of TCEs as eligible subject matter for trade mark registration is preferable to seeking a post factum remedy.
Minding the Care Gap: Daycare Usage and the Negotiation of Work, Family and Gender Among Swedish Parents
Authors: Grönlund Anne , Öun Ida 
Published: May 2020

AbstractThe article asks whether daycare can alleviate work–family tensions in the dual-earner society or if perceptions of 'care gaps' will hamper women's careers. Using survey data from Swedish parents with pre-school children (n ≈ 2250) and qualitative interviews of survey respondents (n = 40), we explore how children’s daycare hours and parents’ reflections on daycare hours are related to mothers’ and fathers’ involvement in paid and unpaid work and to their perceptions of stress. The results show that parents have a strong ambition to limit daycare hours. This ambition provides a stressful dilemma for mothers but for fathers, daycare is not a source of stress. Maternal part-time work is an important tool for managing daycare hours, but collides with ideals of gender equality. Full-time work can be combined with short daycare hours, provided that the parents take shifts in the home and share care responsibilities. Sharing of care work also reduces mothers' stress. However, such arrangements require flexible schedules which are more available to parents in high-skill jobs. Single parents have little opportunity to keep daycare hours short.
Fertility preservation procedures in girls, adolescents and women
Authors: Böttcher Bettina , Goeckenjan Maren 
Published: May 2020

SummaryFertility preservation has become an integral part of standard treatment for young patients with planned gonadotoxic therapy. The decision-making process is an interdisciplinary challenge to both oncologists and radiotherapists involved in the process of diagnosis and treatment. Nevertheless, even today, not every patient receives adequate counselling about fertility preserving techniques. Current data on the options of fertility preservation for women, including cryopreservation of oocytes, embryos, ovarian tissue, transposition of ovaries and medical treatment, are summarized in this review.
Cardiovascular Magnetic Resonance and Sport Cardiology: a Growing Role in Clinical Dilemmas
Authors: Maestrini Viviana , Torlasco Camilla , Hughes Rebecca , Moon James C. 
Published: May 2020

AbstractExercise training induces morphological and functional cardiovascular adaptation known as the “athlete’s heart” with changes including dilatation, hypertrophy, and increased stroke volume. These changes may overlap with pathological appearances. Distinguishing athletic cardiac remodelling from cardiomyopathy is important and is a frequent medical dilemma. Cardiac magnetic resonance (CMR) has a role in clinical care as it can refine discrimination of health from a disease where ECG and echocardiography alone have left or generated uncertainty. CMR can more precisely assess cardiac structure and function as well as characterise the myocardium detecting key changes including myocardial scar and diffuse fibrosis. In this review, we will review the role of CMR in sports cardiology.
Periodic Orbits and Global Stability for a Discontinuous SIR Model with Delayed Control
Authors: Muqbel Khalil , Vas Gabriella , Röst Gergely 
Published: May 2020

AbstractWe propose and analyse a mathematical model for infectious disease dynamics with a discontinuous control function, where the control is activated with some time lag after the density of the infected population reaches a threshold. The model is mathematically formulated as a delayed relay system, and the dynamics is determined by the switching between two vector fields (the so-called free and control systems) with a time delay with respect to a switching manifold. First we establish the usual threshold dynamics: when the basic reproduction number $$\,{\mathcal {R}}_0\le 1$$

R
0

≤
1

, then the disease will be eradicated, while for $$\,{\mathcal {R}}_0>1$$

R
0

>
1

the disease persists in the population. Then, for $$\,{\mathcal {R}}_0>1$$

R
0

>
1

, we divide the parameter domain into three regions, and prove results about the global dynamics of the switching system for each case: we find conditions for the global convergence to the endemic equilibrium of the free system, for the global convergence to the endemic equilibrium of the control system, and for the existence of periodic solutions that oscillate between the two sides of the switching manifold. The proof of the latter result is based on the construction of a suitable return map on a subset of the infinite dimensional phase space. Our results provide insight into disease management, by exploring the effect of the interplay of the control efficacy, the triggering threshold and the delay in implementation.
Comprehensive Design of the High-Sulfur-Loading Li–S Battery Based on MXene Nanosheets
Authors: Zhang Shouzheng , Zhong Ning , Zhou Xing , Zhang Mingjie , Huang Xiangping , Yang Xuelin , Meng Ruijin , Liang Xiao 
Published: May 2020

AbstractThe lithium-sulfur battery is the subject of much recent attention due to the high theoretical energy density, but practical applications are challenged by fast decay owing to polysulfide shuttle and electrode architecture degradation. A comprehensive study of the sulfur host microstructure design and the cell architecture construction based on the MXene phase (Ti3C2Tx nanosheets) is performed, aiming at realize stable cycling performance of Li–S battery with high sulfur areal loading. The interwoven KB@Ti3C2Tx composite formed by self-assembly of MXene and Ktejen black, not only provides superior conductivity and maintains the electrode integrality bearing the volume expansion/shrinkage when used as the sulfur host, but also functions as an interlayer on separator to further retard the polysulfide cross-diffusion that possibly escaped from the cathode. The KB@Ti3C2Tx interlayer is only 0.28 mg cm−2 in areal loading and 3 μm in thickness, which accounts a little contribution to the thick sulfur electrode; thus, the impacts on the energy density is minimal. By coupling the robust KB@Ti3C2Tx cathode and the effective KB@Ti3C2Tx modified separator, a stable Li–S battery with high sulfur areal loading (5.6 mg cm−2) and high areal capacity (6.4 mAh cm−2) at relatively lean electrolyte is achieved.
Vowel-consonant metathesis in Nivaĉle
Authors: Gutiérrez Analía 
Published: May 2020

AbstractVowel-consonant metathesis is observed in a variety of contexts throughout the Nivaĉle (Mataguayan) grammar. It occurs in both verbal and nominal domains, characteristically resulting from the affixation of a consonant-initial suffix to a consonant-final stem. This paper provides an optimality theoretic account for vowel-consonant metathesis and vowel epenthesis in Nivaĉle. It is demonstrated that metathesis responds to phonological requirements; specifically, it serves to avoid marked structures in the language: complex codas, derived complex onsets, and bad syllable contacts. The prosodic analysis of syllable structure constraints aims to provide broad empirical coverage, as well as a coherent and integrated theoretical interpretation.