bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Sn interlayer on mechanical properties and microstructure in Al/Mg friction stir lap welding with different rotational speeds
Authors: Zheng Bo , Zhao Li , Lv Qingquan , Wan Ge , Cai Da , Dong Shijie , Hu Xinbin 
Published: July 2020

Abstract
The effect of Sn foil layers on the mechanical properties and microstructure of friction stir lap welded 5052 aluminium alloy and AZ31B magnesium alloy was explored in this study. Models of numerous joints were set by different rotational (700, 900, 1100, 1300 and 1500 rpm) and welding speeds (50 mm min−1). Mg/Al dissimilar lap joints with and without Sn interlayer were produced by friction stir lap welding. The results suggest that Mg2Sn intermetallic compounds formed instead of Mg17Al12 and Mg2Al3 intermetallic compounds. In direct welding, the joint are only connected by metallurgical bonding between atoms (Mg/Al). In solder joints with Sn interlayer, the joint is connected by the combined effect of metallurgical bonding between atoms (Mg/Sn, Al/Sn) and interface mechanical coupling. For the joint with Sn interlayer, the maximum fracture load of the joint with the Sn interlayer reached 3.72 kN at a rotational speed of 900 rpm. As the rotational speed is increased from 1300 rpm to 1500 rpm, the Sn content on the the advancing side and the retreating side is more, resulting in more Mg2Sn crystal content, increased crack content. The joint performance gradually decreases. For the joint without a Sn interlayer, the microscopic morphology was a river-like pattern, which was characterized by brittle fracture. For a joint with a Sn interlayer, the microscopic morphology contained micro-dimples and a small quantity of inclusions, which were characterized by mixed fracture.
Artificial neural network approach for the prediction of wear for Al6061 with reinforcements
Authors: Baig Rahmath Ulla , Javed Syed , Kazi Azharuddin , Quyam Mohammed 
Published: July 2020

Abstract
In the prospect of finding a lightweight and wear-resistant materials, researchers have considered aluminium-based metal matrix composites (MMC), as aluminium has a wide variety of applications but possesses low wear resistance properties. To enhance the wear resistance of aluminium alloys, ceramic particles are reinforced. In this endeavour, commercially available aluminium alloy is reinforced with 2, 4 and 6 wt% of silicon carbide (SiC) and Vanadium pentoxide (V2O5) powder to improve its wear resistance. The intensity of reinforcement in the matrix was uniform, and the Scanning Electron Microscope image showed the grain refinement and grain boundary of the MMC’s. Wear tests were performed for L16 array set, uncertainty analysis of wear measurement is evaluated, and data were used to develop Artificial Neural Network (ANN) model. The efficient ANN model with a regression coefficient of 0.999 was used to make predictions for remaining sets. Experimental and predicted wear results were analysed; it is observed that higher wt% reinforcement of V2O5 increased wear resistance of aluminium compared to SiC. The methodology adapted using ANN for prediction of wear using meagre experimentation, will lay a path for tribologists to predict the wear of novel metal matrix composites in their endeavour of finding wear-resistant materials.
On conformal field theories based on Takiff superalgebras
Authors: Quella Thomas 
Published: July 2020

Abstract
We revisit the construction of conformal field theories based on Takiff algebras and superalgebras that was introduced by Babichenko and Ridout. Takiff superalgebras can be thought of as truncated current superalgebras with

Z

-grading which arise from taking p copies of a Lie superalgebra

g

and placing them in the degrees

s
=
0
,
…
,

p
−
1

. Using suitably defined non-degenerate invariant forms we show that Takiff superalgebras give rise to families of conformal field theories with central charge

c
=
p
sdim
g

. The resulting conformal field theories are defined in the standard way, i.e. they lend themselves to a Lagrangian description in terms of a WZW model and their chiral energy momentum tensor is the one obtained naturally from the usual Sugawara construction. In view of their intricate representation theory they provide interesting examples of conformal field theories.
Scottish dentistry and broken promises: Woollard on presuppositions and substantial negative facts
Authors: Sneddon Andrew 
Published: July 2020

Abstract
Fiona Woollard claims that negative facts are parts of sequences leading to upshots when they are contrary to the presuppositions of the local community. There are three problems with Woollard’s use of presuppositions. The first is that it fails to capture an important part of our everyday understanding of doing and allowing. The second is that negative facts can be suitable to be parts of sequences even when they accord with presuppositions. The third is that even when negative facts are contrary to presuppositions, this need not be what makes them suitable to be parts of sequences of facts.
Prediction of the early response to spironolactone in resistant hypertension by the combination of matrix metalloproteinase-9 activity and arterial stiffness parameters
Authors: Rodríguez-Sánchez Elena , Navarro-García José Alberto , Aceves-Ripoll Jennifer , González-Lafuente Laura , Baldan-Martin Montserrat , de la Cuesta Fernando , Alvarez-Llamas Gloria , Barderas María G , Segura Julián , Ruilope Luis M , Ruiz-Hurtado Gema 
Published: July 2020

AbstractAimsThe aim of this study was to determine whether arterial stiffness assessed with the biochemical parameter active matrix metalloproteinase (MMP)-9 and the clinical parameters pulse pressure (PP) and pulse wave velocity predicts the response to spironolactone in resistant hypertension (RH).Methods and resultsAmbulatory blood pressure (BP) and active MMP-9 (measured by zymography and ELISA) were measured at baseline, and patients were classified as having pseudo-RH or RH. Patients with RH received spironolactone and the response was determined after 8 weeks by ambulatory BP monitoring: those who achieved BP goals were considered controlled (CRH) and those who did not were considered uncontrolled (UCRH). Plasma active MMP-9 was significantly higher in patients with RH than with pseudo-RH, and correlated with 24 h systolic BP and PP. Receiver operating characteristic analysis indicated that active MMP-9 could predict the response to spironolactone, and its combination with 24 h PP and pulse wave velocity significantly improved this prediction. Moreover, plasma of patients with UCRH induced the MMP-9 expression pathway.ConclusionWe propose active MMP-9 as a useful biomarker to identify patients with RH who will not respond to spironolactone. Combining MMP-9 activity with classical arterial stiffness parameters improves the prediction of the clinical response to spironolactone and might contribute to guide the most appropriate therapeutic decisions for patients with RH.
Knowledge gaps, lack of confidence, and system barriers to guideline implementation among European physicians managing patients with CIED lead or infection complications: a European Heart Rhythm Association/European Society of Cardiology educational needs assessment survey
Authors: Rao Archana , Garner Daniel , Starck Christoph , Kirkfeldt Rikke Esberg , Dagres Nikolaos , Didier Klug , Montano Nicolas , Heidbuchel Hein 
Published: July 2020

Abstract
As the number of patients with cardiac implantable electronic devices (CIEDs) grows, they are likely to present with issues to diverse groups of physicians. Guideline-adherent management is associated with improved prognosis in patients with CIED infection or lead problems but is insufficiently implemented in practice. The European Heart Rhythm Association (EHRA) with the support of the European Society of Cardiology (ESC) Working Group on Cardiovascular Surgery, performed a multinational educational needs assessment study in ESC member countries, directed at physicians who might be confronted with CIED patients with complications. A total of 336 physicians from 43 countries, reached through the ESC mailing list, participated. They included a mix of electrophysiologists, cardiologists general physicians and cardiac surgeons .One hundred and twenty-nine (38%) of the respondents performed lead extraction. The survey included eight clinical cases and a self-evaluation question of knowledge and skills to apply that knowledge. The survey looked at 14 areas of care across five stages of the patient journey. Of the non-extracting physicians over 50% felt they lacked the knowledge and skills to make the diagnosis and refer for lead extraction and over 75% felt they lacked knowledge and skills to manage aspects of extraction and post-extraction care. Barriers to correct referral were logistic and attitudinal. Extracting physicians reported significantly higher rates of adequate skills and knowledge across all five stages of the patient journey (P &lt; 0.05). We identified major gaps in physicians’ knowledge and skills across all stages of CIED care. These gaps should be addressed by targeted educational activities and streamlining referral pathways.
Safety of smartwatches and their chargers in patients with cardiac implantable electronic devices
Authors: Tzeis Stylianos , Asvestas Dimitrios , Moraitis Nektarios , Vardas Emmanuel P , Mililis Panagiotis , Letsas Konstantinos , Kouvelas Konstantinos , Nikita Konstantina S , Vardas Panos 
Published: July 2020

AbstractAimsCardiac implantable electronic devices (CIEDs) are susceptible to electromagnetic interference (EMI). Smartwatches and their chargers could be a possible source of EMI. We sought to assess whether the latest generation smartwatches and their chargers interfere with proper CIED function.Methods and resultsWe included consecutive CIED recipients in two centres. We tested two latest generation smartwatches (Apple Watch and Samsung Galaxy Watch) and their charging cables for potential EMI. The testing was performed under continuous electrocardiogram recording and real-time device telemetry, with nominal and ‘worst-case’ settings. In vitro magnetic field measurements were performed to assess the emissions from the tested devices, initially in contact with the probe and then at a distance of 10 cm and 20 cm. In total, 171 patients with CIEDs (71.3% pacemakers–28.7% implantable cardioverter-defibrillators) from five manufacturers were enrolled (63.2% males, 74.8 ± 11.4 years), resulting in 684 EMI tests. No EMI was identified in any patient either under nominal or ‘worst-case scenario’ programming. The peak magnetic flux density emitted by the smartwatches was similar to the background noise level (0.81 μT) even when in contact with the measuring probe. The respective values for the chargers were 4.696 μΤ and 4.299 μΤ for the Samsung and Apple chargers, respectively, which fell at the background noise level when placed at 20 cm and 10 cm, respectively.ConclusionTwo latest generation smartwatches and their chargers resulted in no EMI in CIED recipients. The absence of EMI in conjunction with the extremely low intensity of magnetic fields emitted by these devices support the safety of their use by CIED patients.
Candida auris:a fungus with identity crisis
Authors: Vila Taissa , Sultan Ahmed S , Montelongo-Jauregui Daniel , Jabra-Rizk Mary Ann 
Published: July 2020

ABSTRACTCandida auris is a new fungal species that has puzzlingly and simultaneously emerged on five continents. Since its identification in 2009, the scientific community has witnessed an exponential emergence of infection episodes and outbreaks in healthcare facilities world-wide. Candida auris exhibits several concerning features compared to other related Candida species, including persistent colonization of skin and nosocomial surfaces, ability to resist common disinfectants and to spread rapidly among patients. Resistance to multiple drug classes and misidentification by available laboratory identification systems has complicated clinical management, and outcomes of infection have generally been poor with mortality rates approaching 68%. Currently, the origins of C. auris are unclear, and therefore, it is impossible to determine whether environmental and climactic changes were contributing factors in its recent emergence as a pathogen. Nevertheless, a robust response involving rapid diagnostics, prompt interventions and implementation of precautions, are paramount in curtailing the spread of infections by this fungal species. Importantly, there is a pressing need for the development of new antifungal drugs. In this article, we present a brief overview highlighting some of the important aspects of C. auris epidemiology, pathogenesis and its puzzling global emergence.
Association Between Urbanicity and Dementia in China: A Population-Based Study
Authors: Luo Yanan , Zhao Yihao , Pang Lihua , Guo Chao , Liang Richard , Zheng Xiaoying 
Published: July 2020

Abstract

Objectives
This study investigated the relationship between urbanicity and dementia and predicted its nonlinear pattern among Chinese adults aged 50 years and older.

Methods
This study used data from the Second National Sample Survey on Disability, which was implemented from April 1 to May 31, 2006 across China. Dementia status was determined by a 2-stage process: the combination of self-reports or family members’ reports and an onsite medical diagnosis by experienced specialists based on the International Statistical Classification of Diseases and Related Health Problems 10th Revision Symptom Checklist for Mental Disorders. Logistic regression models were used to examine the relationship between urbanicity and dementia, and restricted polynomial spline regression models were plotted to examine the nonlinear exposure–response relationship of urbanicity and dementia.

Results
Logistic regression results showed that an increase of 10% in the degree of urbanization was associated with a 73% decrease in the odds of dementia after adjusting for covariates, particularly area-level socioeconomic variables. This observed association was stronger in the younger age group, and this age group difference was only present in women. Spline regression findings suggested a nonlinear exposure–response relationship between urbanicity and the odds of dementia. Areas with very high levels of urbanization were associated with increased odds of dementia.

Conclusions
These findings highlight the necessity to properly examine the nuanced relationship between urbanicity and mental health, especially for women in the younger age group. Notably, there were increased odds of dementia at very high levels of urbanicity.
Effectiveness of remdesivir in patients with COVID-19 under mechanical ventilation in an Italian ICU
Authors: Pasquini Zeno , Montalti Roberto , Temperoni Chiara , Canovari Benedetta , Mancini Mauro , Tempesta Michele , Pimpini Daniela , Zallocco Nicoletta , Barchiesi Francesco 
Published: July 2020

Abstract

Background
Remdesivir is a prodrug with in vitro activity against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Its clinical efficacy in patients with COVID-19 under mechanical ventilation remains to be evaluated.

Methods
This study includes patients under mechanical ventilation with confirmed SARS-CoV-2 infection admitted to the ICU of Pesaro hospital between 29 February and 20 March 2020. During this period, remdesivir was provided on a compassionate use basis. Clinical characteristics and outcome of patients treated with remdesivir were collected retrospectively and compared with those of patients hospitalized in the same time period.

Results
A total of 51 patients were considered, of which 25 were treated with remdesivir. The median (IQR) age was 67 (59–75.5) years, 92% were men and symptom onset was 10 (8–12) days before admission to ICU. At baseline, there was no significant difference in demographic characteristics, comorbidities and laboratory values between patients treated and not treated with remdesivir. Median follow-up was 52 (46–57) days. Kaplan–Meier curves showed significantly lower mortality among patients who had been treated with remdesivir (56% versus 92%, P &lt; 0.001). Cox regression analysis showed that the Charlson Comorbidity Index was the only factor that had a significant association with higher mortality (OR 1.184; 95% CI 1.027–1.365; P = 0.020), while the use of remdesivir was associated with better survival (OR 3.506; 95% CI 1.768–6.954; P &lt; 0.001).

Conclusions
In this study the mortality rate of patients with COVID-19 under mechanical ventilation is confirmed to be high. The use of remdesivir was associated with a significant beneficial effect on survival.
Mesoscale modelling of optical turbulence in the atmosphere: the need for ultrahigh vertical grid resolution
Authors: Basu S , Osborn J , He P , DeMarco A W 
Published: July 2020

ABSTRACT
The high-fidelity modelling of optical turbulence is critical to the design and operation of a new class of emerging highly sophisticated astronomical telescopes and adaptive optics instrumentation. In this study, we perform retrospective simulations of optical turbulence over the Hawaiian islands using a mesoscale model. The simulated results are validated against thermosonde data. We focus on turbulence in the free atmosphere, above the atmospheric boundary layer. The free atmosphere is particularly important for adaptive optics performance and for sky coverage calculations and hence has significant impact on performance optimization and scheduling of observations. We demonstrate that a vertical grid spacing of 100 m or finer is needed to faithfully capture the intrinsic variabilities of observed clear air turbulence. This is a particularly timely study because the next generation of extremely large telescopes are currently under construction and their associated suite of instruments are in the design phase. Knowledge of the expected accuracy of optical turbulence simulations and real-time forecasts will enable the design teams to (i) test and develop instrument designs and (ii) formulate operational procedure.
Influence of galactic arm scale dynamics on the molecular composition of the cold and dense ISM III. Elemental depletion and shortcomings of the current physico-chemical models
Authors: Wakelam V , Iqbal W , Melisse J-P , Gratier P , Ruaud M , Bonnell I 
Published: July 2020

ABSTRACT
We present a study of the elemental depletion in the interstellar medium. We combined the results of a Galactic model describing the gas physical conditions during the formation of dense cores with a full-gas-grain chemical model. During the transition between diffuse and dense medium, the reservoirs of elements, initially atomic in the gas, are gradually depleted on dust grains (with a phase of neutralization for those which are ions). This process becomes efficient when the density is larger than 100 cm−3. If the dense material goes back into diffuse conditions, these elements are brought back in the gas phase because of photo-dissociations of the molecules on the ices, followed by thermal desorption from the grains. Nothing remains on the grains for densities below 10 cm−3 or in the gas phase in a molecular form. One exception is chlorine, which is efficiently converted at low density. Our current gas–grain chemical model is not able to reproduce the depletion of atoms observed in the diffuse medium except for Cl, which gas abundance follows the observed one in medium with densities smaller than 10 cm−3. This is an indication that crucial processes (involving maybe chemisorption and/or ice irradiation profoundly modifying the nature of the ices) are missing.
The TESS light curve of the eccentric eclipsing binary 1SWASP J011351.29+314909.7 – no evidence for a very hot M-dwarf companion
Authors: Swayne Matthew I , Maxted Pierre F L , Kunovac Hodžić Vedad , Triaud Amaury H M J 
Published: July 2020

ABSTRACT
A 2014 study of the eclipsing binary star 1SWASPJ011351.29+314909.7 (J0113+31) reported an unexpectedly high effective temperature for the M-dwarf companion to the 0.95-M⊙ primary star. The effective temperature inferred from the secondary eclipse depth was ∼600 K higher than the value predicted from stellar models. Such an anomalous result questions our understanding of low-mass stars and might indicate a significant uncertainty when inferring properties of exoplanets orbiting them. We seek to measure the effective temperature of the M-dwarf companion using the light curve of J0113+31 recently observed by the Transiting Exoplanet Survey Satellite (TESS). We use the pycheops modelling software to fit a combined transit and eclipse model to the TESS light curve. To calculate the secondary effective temperature, we compare the best-fitting eclipse depth to the predicted eclipse depths from theoretical stellar models. We determined the effective temperature of the M dwarf to be Teff,2 = 3208 ± 43 K, assuming log g2 = 5, [Fe/H] = −0.4, and no alpha-element enhancement. Varying these assumptions changes Teff,2 by less than 100 K. These results do not support a large anomaly between observed and theoretical low-mass star temperatures.
Does the HR 6819 triple system contain a dormant black hole? Not necessarily
Authors: Mazeh Tsevi , Faigler Simchon 
Published: July 2020

ABSTRACT
A recent paper by Rivinius et al. proposed that HR 6819 is a triple system, with a distant Be star and a binary of 40-d orbit, composed of a B3 III giant and a dormant black hole (BH). We suggest that the evidence for this model is not conclusive. In an alternative model, the companion of the giant is by itself a short-period binary in, say, a ∼4-d orbit, consisting, for example, of two A0 stars. Each of the two A0 stars should contribute ${\sim}4{{\ \rm per cent}}$ of the total brightness of the system in the V band, and their spectral lines are moving due to their assumed orbital motion with an unknown period. Therefore, only a careful analysis of the observed spectra can exclude such a model. Before such an analysis is presented and upper limits for the depths of the hypothetical A0 star absorption lines are derived, the model of a hidden close pair is more probable than the BH model.
Lipid–oligonucleotide conjugates for bioapplications
Authors: Li Xiaowei , Feng Kejun , Li Long , Yang Lu , Pan Xiaoshu , Yazd Hoda Safari , Cui Cheng , Li Juan , Moroz Leonid , Sun Yujia , Wang Bang , Li Xiang , Huang Tong , Tan Weihong 
Published: July 2020

Abstract
Lipid–oligonucleotide conjugates (LONs) are powerful molecular-engineering materials for various applications ranging from biosensors to biomedicine. Their unique amphiphilic structures enable the self-assembly and the conveyance of information with high fidelity. In particular, LONs present remarkable potential in measuring cellular mechanical forces and monitoring cell behaviors. LONs are also essential sensing tools for intracellular imaging and have been employed in developing cell-surface-anchored DNA nanostructures for biomimetic-engineering studies. When incorporating therapeutic oligonucleotides or small-molecule drugs, LONs hold promise for targeted therapy. Moreover, LONs mediate the controllable assembly and fusion of vesicles based on DNA-strand displacements, contributing to nanoreactor construction and macromolecule delivery. In this review, we will summarize the general synthesis strategies of LONs, provide some characterization analysis and emphasize recent advances in bioanalytical and biomedical applications. We will also consider the relevant challenges and suggest future directions for building better functional LONs in nanotechnology and materials-science applications.