bluuebunny/crossref_metadata_2025_split huggingface dataset:
SEPSIS project: a protocol for studying biomarkers of neonatal sepsis and immune responses of infants in a malaria-endemic region
Authors: Fievet Nadine , Ezinmegnon Sem , Agbota Gino , Sossou Darius , Ladekpo Rodolphe , Gbedande Komi , Briand Valerie , Cottrell Gilles , Vachot Laurence , Yugueros Marcos Javier , Pachot Alexandre , Textoris Julien , Blein Sophie , Lausten-Thomsen Ulrik , Massougbodji Achille , Bagnan Lehila , Tchiakpe Nicole , d'Almeida Marceline , Alao Jules , Dossou-Dagba Ida , Tissieres Pierre 
Published: July 2020

IntroductionNeonatal sepsis outreaches all causes of neonatal mortality worldwide and remains a major societal burden in low and middle income countries. In addition to limited resources, endemic morbidities, such as malaria and prematurity, predispose neonates and infants to invasive infection by altering neonatal immune response to pathogens. Nevertheless, thoughtful epidemiological, diagnostic and immunological evaluation of neonatal sepsis and the impact of gestational malaria have never been performed.Methods and analysisA prospective longitudinal multicentre follow-up of 580 infants from birth to 3 months of age in urban and suburban Benin will be performed. At delivery, and every other week, all children will be examined and clinically evaluated for occurrence of sepsis. At delivery, cord blood systematic analysis of selected plasma and transcriptomic biomarkers (procalcitonin, interleukin (IL)-6, IL-10, IP10,CD74andCX3CR1) associated with sepsis pathophysiology will be evaluated in all live births as well as during the follow-up, and when sepsis will be suspected. In addition, whole blood response to selected innate stimuli and extensive peripheral blood mononuclear cells phenotypic characterisation will be performed. Reference intervals specific to sub-Saharan neonates will be determined from this cohort and biomarkers performances for neonatal sepsis diagnosis and prognosis tested.Ethics and disseminationEthical approval has been obtained from the Comité d’Ethique de la Recherche – Institut des Sciences Biomédicales Appliquées (CER-ISBA 85 - 5 April 2016, extended on 3 February 2017). Results will be disseminated through international presentations at scientific meetings and publications in peer-reviewed journals.Trial registration numberClinicalTrials.gov registration number:NCT03780712.
New model of integrated care for uncontrolled type 2 diabetes in a retrospective, underserved adult population in the USA: a study protocol for an effectiveness and cost-effectiveness analysis
Authors: Bosetti Rita , Tabatabai Laila , Naufal George , Brito Rosbel , Kash Bita 
Published: July 2020

IntroductionType 2 diabetes prevalence is increasing in the USA, especially in underserved populations. Patient outcomes can be improved by providing access to specialty care within Federally Qualified Health Centers, possibly improving the cost-effectiveness of diabetes care.Methods and analysisA new model of diabetes care based on multidisciplinary teams of clinical fellows, supported by an endocrinologist for underserved adult populations, is presented. The study uses a retrospective, non-randomised cohort of patients with diabetes who visited the community clinic between 1 January 2012 and 31 December 2018. A quasi-experimental method to analyse the causal evidence of the effect of the new model is presented. Discontinuity regression is used to compare two interventions, the intervention by a Clinical Fellow Endocrinology Programme and usual care by a primary care physician. Patients are referred to the Clinical Fellow Endocrinology Programme in case of uncontrolled diabetes (glycated haemoglobin (HbA1c)≥9%). The regression discontinuity design allows the construction of a treatment group for patients with an HbA1c equal or above the threshold in comparison with a control group for patients with an HbA1c below the threshold. The patient outcomes and cost-effectiveness of the new model are analysed. Regression models will be used to assess the differences between treatment and control groups.Ethics and disseminationQuantitative patient data are received by the study team in a de-identified format for analysis via an institutional review board-approved protocol. The quantitative study has been approved by the Houston Methodist Research Institute Institutional Review Board, Houston, Texas, USA. Anticipated results will not only provide evidence about the impact of patient outcomes in underserved diabetic populations, but also give an idea of the cost-effectiveness of the new model and whether or not cost savings can be attained for patients, third-party payers and society. The results will help set up evidence-based policy guidelines in diabetes care. Results will be disseminated through papers, conferences and public health/policy fora.
Bridging the gap between physical and mental illness in community pharmacy (PharMIbridge): protocol for an Australian cluster randomised controlled trial
Authors: Wheeler Amanda J , O'Reilly Claire L , El-Den Sarira , Byrnes Joshua , Ware Robert S , McMillan Sara S 
Published: July 2020

IntroductionThere is a significant life expectancy gap attributable to physical comorbidities for people living with severe and persistent mental illness (SPMI) compared with the general population. Medications are a major treatment for SPMI management and physical illnesses, hence pharmacists are well positioned to support mental healthcare and comorbidities. The randomised controlled trial (RCT) aim is to evaluate effectiveness of an individualised, pharmacist led, support service for people experiencing SPMI focusing on medication adherence and physical comorbidity management, compared with standard care (a medication-management service; MedsCheck).Methods and analysisPharMIbridge is a cluster RCT, whereby community pharmacies in four Australian regions will be randomised (1:1 ratio), to either Intervention Group (IG) or Comparator Group (CG). All IG and CG pharmacy staff will receive Blended-Mental Health First Aid training. Additionally, IG pharmacists will receive further training on medication adherence, goal setting, motivational interviewing, managing physical health concerns and complex issues relating to psychotropic medication. CG pharmacists will not receive additional training, and will provide standard care (MedsCheck). The primary outcome will be change in participants medication adherence for psychotropic medication over 6-months. Using mixed-effects logistic regression model and a cluster size of 48 pharmacies, a total of 190 participants will need to be recruited to each arm to find a statistically significant difference in medication adherence. Secondary outcomes will be changes in factors associated with cardiometabolic risk and quality of life, emphasising physical and psychological well-being; medication-related problems; adherence to other prescribed medication; pharmacists knowledge, confidence and ability to support people experiencing SPMI; and effects on healthcare utilisation. A within RCT-based economic evaluation comparing the intervention with standard care will be undertaken.Ethics and disseminationThe protocol and pharmacist training programme received Griffith University Human Research Ethics Committee approval (HREC/2019/473 and HREC/2019/493 respectively). Results will be published in peer-reviewed journals and available at the Sixth Community Pharmacy Agreement website (http://6cpa.com.au/about-6cpa/).Trial registration numberANZCTR12620000577910.
Severe pain from shingles: a hydrocolloid dressing helps
Authors: Kiedrowski Miroslaw 
Published: July 2020

ObjectiveThis case report presents an uncommon case of hydrocolloid dressing efficacy in pain control in herpes zoster reactivation with vast epidermis damage.MethodsIt is an instructive tale presenting the application of hydrocolloid dressing in a ripe old age woman with locally advanced breast cancer suffering from the fourth shingles reactivation.ResultsThe application of hydrocolloid dressing led to the rapid improvement of pain control (Visual Analogue Scale decreased from 9/10 to 4/10). It also improved the quality of life and promoted the rapid healing of damaged skin.ConclusionIn light of the described case, the application of hydrocolloid dressing could be considered in patients suffering from severe neuropathic pain in shingles, especially in severe cases. Further clinical studies are recommended.
Mist1+ gastric isthmus stem cells are regulated by Wnt5a and expand in response to injury and inflammation in mice
Authors: Nienhüser Henrik , Kim Woosook , Malagola Ermanno , Ruan Tuo , Valenti Giovanni , Middelhoff Moritz , Bass Adam , Der Channing J , Hayakawa Yoku , Wang Timothy C 
Published: July 2020

Background and aimsThe gastric epithelium undergoes continuous turnover. Corpus epithelial stem cells located in the gastric isthmus serve as a source of tissue self-renewal. We recently identified the transcription factor Mist1 as a marker for this corpus stem cell population that can give rise to cancer. The aim here was to investigate the regulation of the Mist1+ stem cells in the response to gastric injury and inflammation.MethodsWe used Mist1CreERT;R26-Tdtomato mice in two models of injury and inflammation: the acetic acid-induced ulcer and infection with Helicobacter felis. We analysed lineage tracing at both early (7 to 30 days) and late (30 to 90 days) time points. Mist1CreERT;R26-Tdtomato;Lgr5DTR-eGFP mice were used to ablate the corpus basal Lgr5+ cell population. Constitutional and conditional Wnt5a knockout mice were used to investigate the role of Wnt5a in wound repair and lineage tracing from the Mist1+ stem cells.ResultsIn both models of gastric injury, Mist1+ isthmus stem cells more rapidly proliferate and trace entire gastric glands compared with the normal state. In regenerating tissue, the number of traced gastric chief cells was significantly reduced, and ablation of Lgr5+ chief cells did not affect Mist1-derived lineage tracing and tissue regeneration. Genetic deletion of Wnt5a impaired proliferation in the gastric isthmus and lineage tracing from Mist1+ stem cells. Similarly, depletion of innate lymphoid cells, the main source of Wnt5a, also resulted in reduced proliferation and Mist1+ isthmus cell tracing.ConclusionGastric Mist1+ isthmus cells are the main supplier of regenerated glands and are activated in part through Wnt5a pathway.
Needs analysis of parents following sudden cardiac death in the young
Authors: McDonald Kristie , Sharpe Louise , Yeates Laura , Semsarian Christopher , Ingles Jodie 
Published: July 2020

ObjectiveThe sudden cardiac death (SCD) of a young person is a devastating event for any parent. Inherited heart disease is often either identified or assumed to be the cause. Few studies have explored the psychosocial impact to the surviving at-risk family members. We sought to investigate the needs of parents who have experienced the SCD of their child (≤45 years).MethodsA quantitative needs analysis questionnaire was developed based on semistructured interviews, including one focus group and a review of relevant literature. Eligible participants were invited to participate in this cross-sectional survey study.ResultsThere were 38 parents who completed a quantitative survey. Parents’ perceived needs for information and support spanned medical, psychosocial, spiritual and financial domains. Of the support and information needs assessed, medical needs were identified as the most important domain, followed by psychosocial, spiritual and financial. Importantly, psychosocial information and support needs were reported as the most unmet need, endorsed by 54% of parents. Medical information and support needs were reported as unmet by almost one third of parents. The two most endorsed needs were ‘To have the option of whether or not you would pursue genetic testing for yourself or family members’ and ‘To understand what happened’.ConclusionsThis work demonstrates for the first time, the multifactorial needs of parents after SCD in the young. With the greatest unmet need reported as psychosocial needs, there is clear necessity to find ways of integrating psychological support in to the care of families after SCD in the young.
Impact of selected comorbidities on the presentation and management of aortic stenosis
Authors: Rudolph Tanja K. , Messika-Zeitoun David , Frey Norbert , Thambyrajah Jeetendra , Serra Antonio , Schulz Eberhard , Maly Jiri , Aiello Marco , Lloyd Guy , Bortone Alessandro Santo , Clerici Alberto , Delle-Karth Georg , Rieber Johannes , Indolfi Ciro , Mancone Massimo , Belle Loic , Lauten Alexander , Arnold Martin , Bouma Berto J , Lutz Matthias , Deutsch Cornelia , Kurucova Jana , Thoenes Martin , Bramlage Peter , Steeds Richard P. 
Published: July 2020

BackgroundContemporary data regarding the impact of comorbidities on the clinical presentation and management of patients with severe aortic stenosis (AS) are scarce.MethodsProspective registry of severe patients with AS across 23 centres in nine European countries.ResultsOf the 2171 patients, chronic kidney disease (CKD 27.3%), left ventricular ejection fraction (LVEF) <50% (22.0%), atrial fibrillation (15.9%) and chronic obstructive pulmonary disease (11.4%) were the most prevalent comorbidities (49.3% none, 33.9% one and 16.8% ≥2 of these). The decision to perform aortic valve replacement (AVR) was taken in a comparable proportion (67%, 72% and 69%, in patients with 0, 1 and ≥2 comorbidities; p=0.186). However, the decision for TAVI was more common with more comorbidities (35.4%, 54.0% and 57.0% for no, 1 and ≥2; p<0.001), while the decision for surgical AVR (SAVR) was decreased with increasing comorbidity burden (31.9%, 17.4% and 12.3%; p<0.001). The proportion of patients with planned AVRs that were performed within 3 months was significantly higher in patients with 1 or ≥2 comorbidities than in those without (8.7%, 10.0% and 15.7%; p<0.001). Furthermore, the mean time to AVR was significantly shorter in patients with one (30.5 days) or ≥2 comorbidities (30.8 days) than in those without (35.7 days; p=0.012). Patients with reduced LVEF tended to be offered an AVR more frequently and with a shorter delay while patients with CKD were less frequently treated.ConclusionsComorbidities in severe patients with AS affect the presentation and management of patients with severe AS. TAVI was offered more often than SAVR and performed within a shorter time period.
Association of protein-energy wasting and inflammation status with mortality after coronary revascularisation in patients on haemodialysis
Authors: Kumada Yoshitaka , Ishii Hideki , Oshima Satoru , Ito Ryuta , Umemoto Norio , Takahashi Hiroshi , Murohara Toyoaki 
Published: July 2020

ObjectiveProtein-energy wasting is associated with chronic inflammation and advanced atherosclerosis in haemodialysis (HD) patients. We investigated association of geriatric nutritional risk index (GNRI), C reactive protein (CRP) with prediction of mortality after coronary revascularisation in chronic HD patients.MethodsWe enrolled 721 HD patients electively undergoing coronary revascularisation. They were divided into tertiles according to preprocedural GNRI levels (tertile 1 (T1):<91.5, T2: 91.5–98.1 and T3:>98.1) and CRP levels (T1:≤1.4 mg/L, T2: 1.5–7.0 mg/L and T3:≥7.1 mg/L).ResultsKaplan-Meier 10 years survival rates were 32.3%, 44.8% and 72.5% in T1, T2 and T3 of GNRI and 60.9%, 49.2% and 23.5% in T1, T2 and T3 of CRP, respectively (p<0.0001 in both). Declined GNRI (HR 2.40, 95% CI 1.58 to 3.74, p<0.0001 for T1 vs T3) and elevated CRP (HR 2.31, 95% CI 1.58 to 3.43, p<0.0001 for T3 vs T1) were identified as independent predictors of mortality. In combined setting of both variables, risk of mortality was 5.55 times higher (95% CI 2.64 to 13.6, p<0.0001) in T1 of GNRI with T3 of CRP than in T3 of GNRI with T1 of CRP. Addition of GNRI and CRP in a model with established risk factors improved C-statistics (0.648 to 0.724, p<0.0001) greater than that of each alone.ConclusionPreprocedural declined GNRI and elevated CRP were closely associated with mortality after coronary revascularisation in chronic HD patients. Furthermore, combination of both variables not only stratified risk of mortality but also improved the predictability.
Mobile application-based guidelines to enhance patient care and provider education in trauma and acute care surgery
Authors: Hakes Nicholas A , Kethman William C , Spain David , Nassar Aussama K 
Published: July 2020

IntroductionProviding up-to-date, universally accessible care guidelines and education within a quaternary care center is challenging. At our institution, trauma and acute care surgery guidelines have historically been published using a paper-based format. Mobile application-based guidelines were developed to address the shortcomings of paper-based guidelines.MethodsWe assessed the utility, usability, and satisfaction of healthcare providers towards paper-based versus mobile application-based guidelines. A survey was administered to providers within the emergency department and intensive care unit.ResultsFifty of 137 providers responded (36.5% response rate). Nearly half (47.4%, 9 of 19) of those who received a copy of the paper-based guidelines lost the guidelines at least once. Regarding usage of the mobile application-based guidelines, 92.6% (25 of 27) were aware of the application; 92.6% (25 of 27) considered the application comprehensive, 85.2% (23 of 27) thought the application was organized, and 66.7% (18 of 27) thought the application was easy to use. Additionally, 88.9% (24 of 27) found the application moderately, very, or extremely helpful and 85.2% (23 of 27) judged the application moderately, very, or extremely necessary. Overall, 88.9% (24 of 27) were satisfied with the application and indicated likeliness to recommend to a colleague. Seventeen of 27 (63.0%) agreed or strongly agreed that the application improved their provision of trauma and acute care.ConclusionThis survey demonstrates positive usability, utility, and satisfaction among trauma healthcare providers with the mobile application-based guidelines. Additionally, this quality improvement initiative highlights the importance of having comprehensive, organized, and easy-to-use trauma and acute care surgery guidelines and targeted educational materials available on demand. The successful transition from paper to mobile application-based guidelines serves as a model for other institutions to modernize and improve patient care and provider education.Level of evidenceIV.
Primary ganglioneuroblastoma in a red deer (Cervus elaphus)
Authors: Nina Ostfeld , Stamatios Alan Tahas , Jean‐Michel Hatt , Monika Hilbe 
Published: July 2020

SUMMARYWe describe the first case of a ganglioneuroblastoma in an adult red deer (Cervus elaphus). This neoplasia showed a unique cervical localisation: it was strongly adhered to the left thyroid gland and contributed to dysphagia via oesophageal compression. Although seldom reported, neoplasias should be included in differential diagnoses for dysphagia in wildlife.
Standardized ileal digestible amino acid contents in flaxseed and flaxseed meals fed to growing–finishing pigs
Authors: Koo Bonjin , Kim Jong Woong , Nyachoti Charles Martin 
Published: July 2020

A total of 10 cannulated barrows with an average body weight of 55.99 ± 3.73 kg were assigned to test diets containing either full-fat flaxseed (FFS), expeller-pressed flaxseed meal (expeller-FM), or solvent-extracted flaxseed meal (solvent-FM). The standardized ileal digestibility (SID) of methionine and threonine was higher (P < 0.05) in FFS than in expeller-FM. Similarly, the SID of crude protein (CP) and threonine was higher (P < 0.05) in FFS than that in solvent-FM. However, expeller-FM and solvent-FM had greater (P < 0.05) contents of SID CP, arginine, leucine, phenylalanine, aspartic acid, glutamic acid, and serine than FFS.
New high precision measurements of the cosmic charged particle rate beyond the Arctic Circle with the PolarquEEEst experiment
Authors: Abbrescia M. , Avanzini C. , Arlandoo M. , Balbi G. , Baldini L. , Ferroli R. Baldini , Batignani G. , Battaglieri M. , Boi S. , Cavazza D. , Bossini E. , Carnesecchi F. , Cicalò C. , Cifarelli L. , Coccetti F. , Coccia E. , Corvaglia A. , De Gruttola D. , De Pasquale S. , Fabbri F. , Falchieri D. , Flammini A. , Galante L. , Garbini M. , Gemme G. , Gnesi I. , Gramstad E. , Grazzi S. , Håland E. S. , Hatzifotiadou D. , La Rocca P. , Liu Z. , Lombardo L. , Mandaglio G. , Margotti A. , Maron G. , Mazziotta M. N. , Meneghini S. , Millerjord S. A. , Mulliri A. , Nania R. , Noferini F. , Nozzoli F. , Ould-Saada F. , Palmonari F. , Panareo M. , Panetta M. P. , Paoletti R. , Parvis M. , Pellegrino C. , Perasso L. , Pinazza O. , Pinto C. , Pisano S. , Riggi F. , Righini G. , Ripoli C. , Rizzi M. , Sartorelli G. , Scapparone E. , Schioppa M. , Scioli G. , Scribano A. , Selvi M. , Serri G. , Squarcia S. , Taiuti M. , Terreni G. , Torromeo G. , Travaglini R. , Trifirò A. , Trimarchi M. , Veri C. , Vistoli C. , Votano L. , Williams M. C. S. , Zichichi A. , Zuyeuski R. 
Published: July 2020

AbstractThe goal of the PolarquEEEst experiment was to measure the cosmic charged particle rate at latitudes greater than 66$$^{\circ }$$∘N, where no systematic and accurate measurements at sea level have ever been performed. A latitude range well above the Arctic Circle was explored on board of a sailboat, up to the unprecedented northernmost value of$$82^{\circ }07^{\prime }$$82∘07′N. In this paper a description of the experimental set-up is reported, then the procedures for calibration and data analysis are described in detail. The results show that the rate measured in this latitude range stays constant within a novel accuracy of$$\pm 1$$±1%.
Twinlike models for parametrized dark energy
Authors: Dantas J. D. , Rodrigues J. J. 
Published: July 2020

AbstractWe study cosmological models involving a single real scalar field that has an equation of state parameter which evolves with cosmic time. We highlight some common parametrizations for the equation of state as a function of redshift in the context of twinlike theories. The procedure is used to introduce different models that have the same acceleration parameter, with the very same energy densities and pressure in flat spacetime.
Characterization of high-purity germanium detectors with amorphous germanium contacts in cryogenic liquids
Authors: Panth R. , Liu J. , Abt I. , Liu X. , Schulz O. , Wei W.-Z. , Mei H. , Mei D.-M. , Wang G.-J. 
Published: July 2020

AbstractFor the first time, planar high-purity germanium detectors with thin amorphous germanium contacts were successfully operated directly in liquid nitrogen and liquid argon in a cryostat at the Max-Planck-Institut für Physics in Munich. The detectors were fabricated at the Lawrence Berkeley National Laboratory and the University of South Dakota, using crystals grown at the University of South Dakota. They survived long-distance transportation and multiple thermal cycles in both cryogenic liquids and showed reasonable leakage currents and spectroscopic performance. Also discussed are the pros and cons of using thin amorphous semiconductor materials as an alternative contact technology in large-scale germanium experiments searching for physics beyond the Standard Model.