bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug Repositioning Study in Search of Potent Inhibitors Blocking Multiple Pathways for the Treatment of Breast Cancer
Authors: Kashaw Sushil Kumar , Agarwal Shivangi , Dixit Anshuman 
Published: July 2020

Abstract
Breast cancer is most malignant cancer in women worldwide. The efforts are going on for improvement in patient’s survival and treatment strategies. The goal of the present work is to find out connections among drugs-genes-breast cancer and to re-purpose approved drugs for the treatment of breast cancer. In this context, the gene expression data of breast cancer samples was analyzed to identify the upregulated/downregulated genes in different clinical stages of breast cancer. A large number of genes were found to be upregulated/downregulated in different clinical stages of breast cancer. Some of the genes were found to be stage specific and some were common to all stages. The biological pathways were studied in early and late stages of breast cancer, which indicated that pathways as Methylglyoxal Degradation I, Catecholamine biosynthesis and Serotonin/Melatonin biosynthesis were enriched in early stage and pathways as Matrix metalloproteases, Airway pathology in COPD, Glycogen degradation II and Glycogen degradation III were enriched in late stages of breast cancer. The drug repurposing analysis revealed that the different classes of drugs as enzyme inhibitors, CNS agents, Glucocorticoids, insulin sensitizers, tubulin inhibitors, adhesion inhibitors showed strong connections with MCF7 cell line. Further, it was found that the drugs as Nortriptyline, AZD-6482, Acitretin and GW-507 were found to target multiple genes in interleukin pathway, enzymatic pathway and GPCR signaling pathway and drugs as Caffeine, Canertinib and Triciribine was found to target multiple genes which were dysregulated and involved in interleukin pathway, enzymatic pathway, GPCR signaling pathway and metabolic pathways.
Screening for GARS Variants in A Cohort of Chinese Patients With Inherited Peripheral Neuropathy
Authors: Sun Bo , He Zheng-Qing , Li Yan-Ran , Wang Hong-Fen , Cui Fang , Yang Fei , Huang Xu-Sheng 
Published: July 2020

Abstract
Background CMT2D is a rare subtype of axonal CMT, caused by the mutation of glycyl-tRNA synthetase (GARS) gene which is also a disease-causing gene of distal spinal muscular atrophy type V (dSMA-V) or hereditary motor neuropathy 5A (HMN5A). There were only several case reports in China, and no epidemiological study of CMT2D/ HMN5A yet.Methods We recruited the patients of Chinese Han descent clinically diagnosed with inherited peripheral neuropathy (IPN) from the Department of Neurology at Chinese PLA General Hospital (Beijing, China) from December 20, 2012 to July 31, 2019. All patients underwent a detailed medical history, neurological examination, laboratory examination, electrophysiological studies, and genetic testing.Results A total of 206 unrelated patients underwent genetic analysis, and we found four mutations of GARS from four different families, including c.794C>T (p.S265F), c.374A>G (p.E125G), c.1000A>T (p.I334F) and c.781T>G (p.Y261D), the first three of them were considered pathogenic. As for the three pathogenic mutation carriers, one patient was diagnosed as CMT2D, two patients were diagnosed as HMN5A.Conclusion GARS mutation is a rare cause of inherited peripheral neuropathy and the phenotype tends to be CMT2D or HMN5A. There might be a relatively higher mutation frequency in Asian population compared with Caucasians. Combination of clinical phenotype, auxiliary tests and genetic evidence to assess the pathogenicity of genetic variants in patients suspected as IPN is of vital importance.
Development and Validation of an Instrument to Measure Parental Factors Related to Substance Use Prevention in Adolescents
Authors: Mehri Seyed Mohsen , Rohban Alireza , Hashemian Masoumeh , Joveini Hamid , Mehri Ali , Rakhshani Mohammad Hassan , Shahrabadi Reza 
Published: July 2020

Background:The average age of using illicit drugs for the first time in adolescents has decreased in Iran over the past years. Studies show that family and environment play a notable role in keeping adolescents away from substances.Aims:The present study is an attempt to develop and validate a model-based questionnaire to measure parental factors related to substance use prevention in adolescents.Methods:This methodological study was carried out on 336 parents of high school students in Sabzevar- Iran, in 2018. The first draft of the questionnaire, including 136 items, was developed based on the constructs of the Health Promotion Model (HPM) using similar questionnaires, literature review, and interviewing 9 qualified experts. The validity of the questionnaire was measured through face validity (qualitative and quantitative), content validity (qualitative and quantitative), and construct validity (confirmatory factor analysis). The reliability of the questionnaire was measured by internal consistency and test-retest reliability. SPSS ver. 16 and LISREL ver. 8.2 software was used for statistical analysis.Results:Throughout the validation process, 35 items were omitted, and the final version of the questionnaire consisting of 101 items was developed. The overall content validity ratio was 0.81, which indicates the proper and understandable content of the items. The overall content validity index was 0.96, which indicates excellent expert validity. The Cronbach’s alpha coefficient of the questionnaire was 0.85 (constructs range= 0.73-0.96), and the intraclass correlation coefficient of the questionnaire was 0.78 (constructs range= 0.46-0.91), which indicates that the questionnaire has good internal consistency and test-retest reliability. Further, the confirmatory factor analysis yielded an appropriate fit for the model (RMSEA= 0.069, χ2/df= 2.77, GFI= 0.60, AGFI= 0.83, CFI= 0.83, NNFI= 0.83).Conclusion:The validity and reliability of the HPM-based questionnaire were supported. Therefore, the questionnaire can be used by health educators and health policymakers in empowerment programs for parents to improve their behavioral skills concerning the prevention of substance use in their adolescents.
PENGARUH PENGELOLAAN SISTEM INFORMASI MANAJEMEN TERHADAP TUGAS GURU SMK NEGERI SE-KABUPATEN MALANG
Authors: Syah Tri Firman 
Published: July 2020

The existence of the role and function of teachers is one of the most important factors in education, both formal and informal education. Problems faced by teachers in Indonesia are: (1) the problem of teacher quality; (2) the problem of the number of teachers who are still lacking; (3) the problem of teacher distribution; (4) the problem of teacher welfare. Data from PSG Rayon 115 of 2012 and Teacher Competency Test (UKG) from 2012 to 2015 shows that there are still many teachers in Malang Regency who have not been able to develop their productivity in teaching. Education in the global era requires the management of modern and professional education with an educational nuance. Educational institutions are expected to be able to realize their role effectively with excellence in leadership, staff, teaching and learning processes, staff development, curriculum, goals and expectations, school climate, self-assessment, communication, and parent / community involvement. Management Information Systems have a role in improving the work of teachers because it can accelerate the work of teachers to deliver material to students making learning tools and student reports. Management information system cannot be separated from the support of facilities and infrastructure used in conveying information and the process of delivering information. The application of a MIS, makes school management neat so as to improve the performance of employees and teachers. In addition the school also cooperates with the company by providing laboratory equipment, instructors, and teacher training for work standards and standards of learning materials needed by the company. So that it can improve the task of the teacher in providing subject matter that has been adapted between the national curriculum and the company.
HUBUNGAN HUKUM INTERNASIONAL DENGAN HUKUM NASIONAL
Authors: Risfalman - - 
Published: July 2020

Hukum internasional banyak dipengaruhi oleh hukum nasional. Sebagai contoh hukum internasional dapat tercipta dengan adanya kebiasaan nasional suatu Negara yang dianut oleh banyak Negara, kebiasaan ini disepakati sebagai hukum internasional. Hukum internasional publik adalah keseluruhan kaidah dan asas hukum yang mengatur hubungan atau persoalan batas Negara (hubungan internasional) yang bukan bersifat perdata, sedangkan hukum nasional adalah sekumpulan hukum yang sebagian besar terdiri atas prinsip-prinsip dan peraturan-peraturan yang harus ditaati oleh masyarakat dalam suatu negara, dan oleh karena itu juga harus ditaati dalam hubungan-hubungan antara mereka satu dengan lainnya. Mengenai hubungan hukum internasional dengan hukum nasional terdapat dua paham. Pertama, paham dualisme yang menyatakan bahwa hukum internasional dengan hukum nasional merupakan dua sistem hukum yang berbeda secara keseluruhannya. Kedua, Paham monisme berpendapat hukum internasional dan hukum nasional saling berkaitan satu sama lainnya.
Keywords : Hubungan, Hukum, Nasional, Internasional
Ancho de distribución plaquetaría como predictor de preeclampsia severa
Authors: Trejos Ramirez Carlos Andres , Ramirez Pescador Fabiana , Rodriguez Ortiz Jorge Augusto , Arreaza Graterol Mortimer 
Published: July 2020

Introducción: La fisiopatología de la preeclampsia no está dilucidada por completo, diferentes índices plaquetarios dentro de los que se incluye el ancho de distribución plaquetaria (ADP) podrían ser utilizado para predecir la severidad en esta condición.
Objetivo: Analizar el comportamiento del ADP en el desarrollo de severidad en preeclampsia en mujeres atendidas en la unidad de medicina materno-fetal del Hospital Simón Bolívar de Bogotá, Colombia.
Materiales y métodos: Estudio de corte trasversal analítico en 105 pacientes con trastorno hipertensivo asociado al embarazo, preeclampsia y preeclampsia severa. Se analizó el comportamiento del ADP en una población de mujeres hipertensas con preeclampsia mediante una curva de análisis ''Receiver Operating Characteristic'' (ROC) para estimar la sensibilidad, tasa de falsos positivos, razón de probabilidad positiva y negativa de la prueba como marcador de desarrollo de severidad
Resultados: El ADP tuvo un ascenso significativo mayor en pacientes donde su progresión de enfermedad desarrollaron características de severidad. En la curva ROC el área bajo la curva para del ADP como predictor de severidad en la preeclampsia fué de 0.68
Conclusión: El ADP es un índice plaquetario que aumentó significativamente en las mujeres con preeclampsia con características de severidad. El ADP podría ser un marcador para la predicción de severidad de la preeclampsia.
Keefektifan Media Roda Jelajah Indonesia terhadap Hasil Belajar Materi Tematik
Authors: Andriani Andriani , Mushafanah Qoriati , Wardhana M. Yusuf Setia 
Published: July 2020

Latar belakang yang mendorong penelitian ini adalah kurangnya alat pendukung kegiatan pembelajaran yang membuat peserta didik pasif sehingga menimbulkan kesulitan dalam mencapai tujuan pembelajaran. Penggunaan media roda jelajah Indonesia menjadi salah satu solusi dalam meningkatkan hasil belajar siswa. Penelitian ini bertujuan untuk mengetahui keefektifan media roda jelajah Indonesia terhadap hasil belajar materi tematik siswa kelas V SD Negeri Karanganyar Gunung 01 Semarang. Jenis penelitian ini adalah penelitian eksperimen berbentuk quasi experimental design dengan desain nonequivalent control group design. Dengan sebanyak 40 siswa. Hasil analisis statistik dengan uji-t diperoleh thitung = 2,272 dan ttabel dengan taraf signifikansi 5% sebesar 2,024. Maka thitung > ttabel maka H0 ditolak dan Ha diterima. Jadi dapat disimpulkan bahwa pengunaan media roda jelajah Indonesia efektif terhadap hasil belajar materi tematik siswa kelas V SD Negeri Karanganyar Gunung 01 Semarang.
Kontribusi Pola Asuh Orang Tua Dan Aktualisasi Diri Terhadap Kompetensi Pengetahuan IPS
Authors: Damayanti Putri , Sujana I W. , Kristia MG. Rini 
Published: July 2020

Penelitian ini bertujuan untuk mengetahui pengaruh yang signifikan antara (1) pola asuh orang tua terhadap kompetensi pengetahuan IPS (2) aktualisasi diri terhadap kompetensi pengetahuan IPS (3) pola asuh orang tua dan aktualisasi diri terhadap kompetensi pengetahuan IPS siswa kelas V SD Gugus Ir. Soekarno Kecamatan Denpasar Selatan. Jenis penelitian ini adalah penelitian ex post facto. Populasi dari penelitian ini berjumlah 458 yang merupakan seluruh siswa kelas V SD Gugus Ir. Soekarno. Metode pengumpulan data yang digunakan yaitu metode kuesioner untuk mengukur pola asuh orang tua dan aktualisasi diri, dan metode pencatatan dokumen berupa nilai ulangan akhir semester 1 (UAS) untuk mencatat kompetensi pengetahuan IPS. Analisis data menggunakan teknik regresi sederhana analisis regresi ganda. Hasil Penelitian menunjukkan bahwa (1) terdapat pengaruh yang signifikan antara pola asuh orang tua terhadap kompetensi pengetahuan IPS dengan kontribusi sebesar 83,4 % (2) terdapat pengaruh yang signifikan antara aktualisasi diri terhadap kompetensi pengetahuan IPS dengan kontribusi sebesar 83% (3) terdapat pengaruh yang signifikan secara bersama-sama antara pola asuh orang tua dan aktualisasi diri terhadap kompetensi pengetahuan IPS dengan kontribusi sebesar 86,3%. Jadi, pola asuh orang tua dan aktualisasi diri berkontribusi terhadap kompetensi pengetahuan IPS siswa kelas V SD Gugus Ir. Soekarno Kecamatan Denpasar Selatan.
Pengaruh Model Pembelajaran Project Based Learning Melalui Percobaan Sederhana Terhadap Kompetensi Pengetahuan IPA
Authors: Apsari Ni Luh Sri , Wiarta I Wyn 
Published: July 2020

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran Project Based Learning melalui percobaan sederhana terhadap kompetensi pengetahuan IPA kelas IV SD Gugus I Mengwi . Penelitian ini merupakan jenis penelitian eksperimen semu dengan rancangan nonequivalent control group design. Populasi dalam penelitian ini adalah seluruh kelas IV SD Negeri di Gugus 1 Mengwi sebanyak 187 siswa. Sampel ditentukan dengan teknik random sampling. Sampel dalam penelitian ini adalah kelas IV SD No. 1 Pererenan sebanyak 32 siswa sebagai kelompok eksperimen dan kelas IV SD No. 1 Cemagi sebanyak 30 siswa sebagai kelompok kontrol. Data tentang kompetensi pengetahuan IPA dikumpulkan dengan instrumen berupa tes objektif. Berdasarkan hasil analisis uji-t data GSn, diperoleh thitung = 5,139, pada pada taraf signifikansi 5% dengan 𝑑𝑘= 32+30−2=60 dan diperoleh ttabel = 2,000. Sehingga dapat diketahui bahwa thitung = 5,139 > ttabel = 2,000 yang berarti H0 ditolak. Berdasarkan hasil analisis tersebut, diketahui bahwa rata-rata data GSn kompetensi pengetahuan IPA siswa pada kelompok eksperimen lebih dari nilai rata-rata pada kelompok kontrol yaitu 𝑋̅1=0,45 > 𝑋̅2=0,32. Jadi, terdapat pengaruh yang signifikan model pembelajaran Project Based Learning melalui percobaan sederhana terhadap kompetensi pengetahuan IPA kelas IV SD Gugus I Mengwi.
Tat Twam Asi Based Role-Playing Learning Model in Social Studies Knowledge Competence
Authors: Agustini Kadek Dwi Intan , Suarjana I Made , Jayanta I Nyoman Laba , Renda Ndara Tanggu 
Published: July 2020

The low competence of Social Studies knowledge possessed by students due to lack of active students in the learning process. This is one of the reasons this research was conducted. This study aimed at examining the impact of Tat Twam Asi based Role-Playing learning model on the mastery of Social Studies competence. This was a quasi-experiment study and the design was an on-equivalent post-test only control group. The population in this study were all grade V of Gugus IV elementary school Buleleng Sub-district, Buleleng regency, amounting to 5 classes with a total of 172 students. The samples were students of SD Negeri 1 Banyuasri as an experimental group with a total of 35 students and SD Negeri 5 Banyuasri as a control group of 32 students determined by applying group design random sampling technique. Data on the competence of Social Studies knowledge were collected by using multiple-choice tests. Descriptive statistics and inferential statistics are t-tests polled variants were applied in analyzing them. After analyzing the data, the t-count is 8,99 while the t-table is 3.99, so the t-count is greater than the t-table. This shows that there are differences in the mastery of IPS knowledge competence between the experimental group and the control group. Based on the findings, it could be concluded that Tat Twam Asi based role play learning model had a significant impact on the mastery of Social Studies knowledge competence. This model can be chosen by the teacher as an alternative in the learning process activities to achieve the expected learning objectives.
SEJARAH MIGRASI ETNIS KARO KE KECAMATAN BAHOROK KABUPATEN LANGKAT
Authors: Rambe Tappil , Sembiring Sri Surabina 
Published: July 2020

ABSTRAKTujuan dalam penelitian ini adalah untuk mengetahui sejarah awal masuknya etnis karo ke sumatera utara dan terkhusus di Kecamatan Bahorok. Penelitian ini dilakukan di kantor Dinas Pendidikan dan kebudayaan Kabupaten Langkat, di kantor Camat Bahorok dan ke dusun – dusun yang ada di Kecamatan Bahorok. Metode yang digunakan dalam penelitian ( field research) dengan pendekatan deskriftif kauntitatif, dimana data yang diperoleh dari lapangan yang berhubungan dengan dengan permasalahan penelitian. Data juga diperoleh dari hasil wawancara dengan para tokoh masyarakat yang mengetahui tentang sejarah migrasi etnis karo ke Kecamatan Bahorok, selain itu data juga diperoleh dari hasil observasi dan dokumentasi. Dari hasil penelitian, peneliti dapat mengetahui mengenai sejarah Suku Karo. Suku Karo yang melakukan migarsi bertahap- tahap sehingga samapi ke Kecamatan Bahorok. Suku Karo mengalami perubahan dalam segi sosial, pendidikan dan adat istiadat dan kehidupan yang lebih biak. Dari keseluruhan hasil penelitian di Lapangan diperoleh kesimpulan bahwa sejarah migrasi etnis Karo ke Bahorok karena terjadinya perlawanan terhadap Kolonialisme dan ingin mencari lahan baru untuk bercocok tanam dan mencari kehidupan yang lebih baik. Kata Kunci : Migrasi, Karo, Marga Silima
PENGARUH MODEL PROBING PROMTING TERHADAP HASIL BELAJAR SISWA DALAM PEMBELAJARAN SEJARAH KELAS X SMA NEGERI 15 MEDAN T.A 2018/2019
Authors: Nasution Abd Haris , Safitri Adelia 
Published: July 2020

Penelitian ini bertujuan untuk mengetahui pengaruh model Probing Promting dalam meningkatkan hasil belajar siswa dalam pembelejaran sejarah. Penelitian ini merupakan penelitian kuantitatif dengan desain penelitian eksperimen, yaitu ada perbedaan perlakukan antara kedua kelas eksperimen dan kelas kontrol agar dapat dilihat perbedaannya. Populasi penelitian ini adalah kelas X SMA Negeri 15 Medan yang terdiri dari 6 kelas dengan jumlah seluruh siswa 210 orang. Pengambilan sampel dalam penelitian ini menggunakan teknik acak atau random sampling, dimana kelas eksperimen adalah kelas X Ips 1 yang diajarkan dengan menggunakan model probing promting dan yang menjadi kelas kontrol adalah kelas X Ips 2 yang diajarkan metode ceramah. Berdasarkan hasil penelitian nilai rata-rata siswa pada kelas X Ips 1 sebesar 83,82, sedangkan nilai rata-rata siswa kelas X Ips 2 adalah sebesar 73,55. Adanya perbedaan hasil belajar tersebut juga terbukti melalui pengujuan hipotesis dengan menggunakan uji-t dan taraf kepercayaan α = 0,05, dimana yaitu dengan demikian dalam penelitian ini ditolak dan diterima, sehingga dapat disimpulkan bahwa ada perbedaan hasil belajar yang signifikan antara model probing promting dengan metode ceramah yaitu lebih tinggi hasil belajar yang menggunakan model probing promting.Kata Kunci : Probing Promting, Hasil Belajar, Sejarah.
Azar y Contingencia: universos en disputa
Authors: Wolfzun Nora 
Published: July 2020

Lewis Carroll era escritor y matemático. La trama que el autor desarrolla en su magistral Alicia en el país de las maravillas se despliega en el marco de una jugada de naipes sin reglas, o con leyes que cambian sin causa alguna. La lectura de Alicia recrea un piso imaginario y cognitivo propicio para introducirnos en las reflexiones filosóficas de Quentin Meillassoux en su libro Después de la finitud, en el que el concepto de transfinito (infinito de infinito) lo lleva a afirmar categóricamente que las propias leyes que gobiernan nuestro mundo y sus cosas pueden ser de otra manera, sin razón alguna, abonando la idea central del libro: la contingencia radical como absoluto especulativo. El presente trabajo diseña su campo de relevancia en torno al intercambio de categorías, insumos y recursos analíticos entre la Crítica Jurídica y el Realismo Especulativo, específicamente centrado en la lectura de Después de la finitud, de Meillassoux.
Hiperplasia prostática e os principais sintomas do aparelho genito-urinário na população masculina de Coari - Amazonas, Brasil
Authors: Almeida Lucas da Silva de , Faria Ricardo dos Santos , Cordeiro Priscilla Mendes , Oliveira Marcelo Brendew Sousa de , Pereira Rhuana Maria de Oliveira , De Araujo Vanessa de Souza Correia , Chagas Yana Azevedo das , Souza Felipe Lopes de , Lima Paula Andreza Viana , Portugal Jéssica Karoline Alves 
Published: July 2020

Objetivo: Determinar a prevalência da Hiperplasia Prostática Benigna e os principais sintomas do aparelho genito-urinário em indivíduos que fazem uso do serviço público de saúde, residentes no município de Coari, Amazonas. Métodos: Trata-se de um estudo transversal, descritivo e observacional realizados com 106 homens a partir de 40 anos. Resultados: A prevalência de Hiperplasia Prostática Benigna na população masculina de Coari – Amazonas foi de 51,9%. Homens com faixa etária de 61 a 70 anos e idade igual ou superior a 71 anos tiveram as maiores taxas de alteração do volume da próstata O escore da intensidade dos sintomas no trato urinário inferior encontrado na maioria dos indivíduos pesquisados foram leves e o grau de disfunção erétil foi de leve a moderado. Conclusão: A Hiperplasia Prostática Benigna foi prevalente na maioria dos homens acima de 40 anos que fizeram uso dos serviços públicos de saúde do município de Coari e a intensidade dos sintomas do aparelho genito-urinário foram de leve a moderado. Esses dados servem de alerta para os profissionais de saúde do município sobre a presença desse agravo e mostram a necessidade de intensificar ou continuar as atividades de saúde voltadas a este público.
Condição oral de dependentes químicos em um município do estado da Paraíba
Authors: Barros Bruna Mayara Gonçalves de , Farias Micaella Fernandes , Oliveira José Jhenikártery Maia de , Pinto Laís Guimarães , Silva Giullianna de Andrade , Souza Kalygia Cavalcanti Alves de , Pereira Laudenice de Lucena , Honorato Maria Cristina Tavares de Medeiros 
Published: July 2020

Objetivo: Identificar a condição oral dos dependentes químicos atendidos em um Centro de Especialidades Odontológicas (CEO), traçar o perfil sociodemográfico, determinando a prevalência de lesões/alterações estomatológicas nestes pacientes. Métodos: Trata-se de um trabalho descritivo com abordagem quantitativa e bibliográfica, realizado no município de João Pessoa-PB. A amostra constituiu-se de 90 prontuários. Os dados foram coletados em ficha clínica elaborada para este fim, tabulados e submetidos à análise descritiva. Resultados: Há uma maior frequência de tabagistas (41%), seguida de etilistas/ tabagistas (39%), apenas etilistas (18%) e usuário de drogas ilícitas (1%). A maioria (60%) destes fazia uso de drogas por mais de 10 anos, numa periodicidade de mais de três vezes por semana. Houve maior prevalência de lesões de menor impacto à saúde (41%), seguida de pacientes sem alterações estomatológicas (32%) e lesões de maior impacto à saúde (27%). Conclusão: Apesar de ser considerada população de risco para o desenvolvimento do câncer de boca, o carcinoma de células escamosas (CCE) foi menos prevalente que a ocorrência de lesões com potencial de malignidade, predominando as alterações estomatológicas de menor impacto à saúde geral dos pacientes.