bluuebunny/crossref_metadata_2025_split huggingface dataset:
DREAM-in-CDM Approach and Identification of a New Generation of Anti-inflammatory Drugs Targeting mPGES-1
Authors: Zhou Shuo , Zhou Ziyuan , Ding Kai , Yuan Yaxia , Loftin Charles , Zheng Fang , Zhan Chang-Guo 
Published: June 2020

AbstractMicrosomal prostaglandin E2 synthase-1 (mPGES-1) is known as an ideal target for next generation of anti-inflammatory drugs without the side effects of currently available anti-inflammatory drugs. However, there has been no clinically promising mPGES-1 inhibitor identified through traditional drug discovery and development route. Here we report a new approach, called DREAM-in-CDM (DrugRepurposingEffortApplying IntegratedModeling-invitro/vivo-ClinicalDataMining), to identify an FDA-approved drug suitable for use as an effective analgesic targeting mPGES-1. The DREAM-in-CDM approach consists of three steps: computational screening of FDA-approved drugs;in vitroand/orin vivoassays; and clinical data mining. By using the DREAM-in-CDM approach, lapatinib has been identified as a promising mPGES-1 inhibitor which may have significant anti-inflammatory effects to relieve various forms of pain and possibly treat various inflammation conditions involved in other inflammation-related diseases such as the lung inflammation caused by the newly identified COVID-19. We anticipate that the DREAM-in-CDM approach will be used to repurpose FDA-approved drugs for various new therapeutic indications associated with new targets.
Effects of Semantic Feature Type, Diversity, and Quantity on Semantic Feature Analysis Treatment Outcomes in Aphasia
Authors: Evans William S. , Cavanaugh Rob , Gravier Michelle L. , Autenreith Alyssa M. , Doyle Patrick J. , Hula William D. , Dickey Michael Walsh 
Published: June 2020

Purpose
Semantic feature analysis (SFA) is a naming treatment found to improve naming performance for both treated and semantically related untreated words in aphasia. A crucial treatment component is the requirement that patients generate semantic features of treated items. This article examined the role feature generation plays in treatment response to SFA in several ways: It attempted to replicate preliminary findings from Gravier et al. (2018), which found feature generation predicted treatment-related gains for both trained and untrained words. It examined whether feature diversity or the number of features generated in specific categories differentially affected SFA treatment outcomes.

Method
SFA was administered to 44 participants with chronic aphasia daily for 4 weeks. Treatment was administered to multiple lists sequentially in a multiple-baseline design. Participant-generated features were captured during treatment and coded in terms of feature category, total average number of features generated per trial, and total number of unique features generated per item. Item-level naming accuracy was analyzed using logistic mixed-effects regression models.

Results
Producing more participant-generated features was found to improve treatment response for trained but not untrained items in SFA, in contrast to Gravier et al. (2018). There was no effect of participant-generated feature diversity or any differential effect of feature category on SFA treatment outcomes.

Conclusions
Patient-generated features remain a key predictor of direct training effects and overall treatment response in SFA. Aphasia severity was also a significant predictor of treatment outcomes. Future work should focus on identifying potential nonresponders to therapy and explore treatment modifications to improve treatment outcomes for these individuals.

Supplemental Material

https://doi.org/10.23641/asha.12462596
NLTE modeling and spectroscopically derived abundances of lithium and beryllium for classical nova ejecta
Authors: Shore Steven N. , De Gennaro Aquino Ivan 
Published: June 2020

Context. Extreme super-solar abundances of lithium and beryllium have been reported in recent years for classical novae based on absorption lines in ultraviolet and optical spectra during the optically thick stages, but these findings have not been compared with spectrum syntheses of the ejecta.
Aims. We present a grid of nova ejecta models calculated with PHOENIX aimed at simulating the reported Li I and Be II features with super-solar abundances.
Methods. We computed a sequence of models, finely exploring the parameter space of effective temperature, ejecta expansion velocity, and Li and Be overabundances.
Results. Regardless of temperature and expansion velocity, the synthetic spectra for large Li and Be overabundances strongly disagree with those presented in recent literature. Assuming a wide range of Be overabundances (factors of 100 to 10 000 relative to solar), we predict a much stronger spectroscopic feature at Be II 3130 Å than those so far observed. A similar overabundance for Li would instead result in a barely observable change in the emitted flux at Li I 6709 Å. The observed extended absorption feature at 3131 Å reported in V838 Her and other novae appears even in zero-Be models with only solar abundances (which for novae are underestimates).
Conclusions. The computed spectra do not support the lithium and beryllium abundances, and caution is warranted in the interpretation of the phenomenology.
Sigmund Freud et la politique. Paul Federn, les siens et leurs amis
Authors: Prado de Oliveira Luiz Eduardo 
Published: June 2020

La psychanalyse peut offrir à ceux qui s’y intéressent de nouvelles manières d’aborder la politique, notamment en prenant en considération la surdétermination du sujet. En prenant comme exemple Freud et Federn, nous montrons les engagements politiques des premiers psychanalystes, ce qui, par contraste, permet d’envisager leur supposée neutralité ultérieure.
Nous signalons ici différentes attitudes politiques de Freud au long de sa vie, dans différents contextes, notamment celui de ses relations avec son fils aîné, Martin. Nous examinons les activités politiques de ceux qui entouraient Freud et particulièrement de Paul Federn, avec qui des liens d’amitié se tissèrent à partir du début du siècle de la psychanalyse jusqu’à leur départ en exil, et qui fut aussi son plus proche collaborateur à partir de 1924.
Hepatitis B und C bei Kindern und Jugendlichen
Authors: Wirth Stefan 
Published: June 2020

ZUSAMMENFASSUNGDie Hepatitis B ist bei Kindern, die fast ausschließlich vertikal infiziert werden, zunächst durch eine immuntolerante Phase mit normalen Transaminasen und hoher Viruslast charakterisiert, die im Verlauf von Jahren in die immunreaktive Phase mit erhöhten Transaminasen übergehen kann. In dieser Zeit kann dann eine Serokonversion zu anti-HBe eintreten, die in der Regel mit der Normalisierung der Transaminasen und einer drastischen Reduktion der Viruslast verbunden ist. Die Therapie ist nur in der immunreaktiven Phase indiziert. Man kann mit Peg-Interferon, Entecavir und Tenofovir behandeln. Das Ziel ist die Serokonversion zu anti-HBe, was meist erst nach Jahren erreicht werden kann.Die Hepatitis C wird ebenfalls fast ausschließlich vertikal übertragen und ist zunächst eine wenig aktive Erkrankung. Die Therapie mit alfa-Interferonen ist aufgrund der neuen oral applizierbaren DAAs (direct antiviral agents) obsolet. Für Kinder ab 12 Jahren sind aktuell drei Kombinationen: Ledipasvir und Sofosbuvir für Genotyp 1 und 4 und Ribavirin mit Sofosbuvir für die Genotypen 2 und 3 sowie pangenotypisch Glecaprevir und Pibrentasvir zugelassen. Dieses Jahr ist mit weiteren Zulassungen für die jüngeren Altersgruppen zu rechnen.
Gallensteine im Kindesalter
Authors: Lang Thomas 
Published: June 2020

ZUSAMMENFASSUNGGallensteine führen bei Kindern und Jugendlichen selten zu klinischen Symptomen, können aber schon bei Säuglingen nachgewiesen werden.Unterschieden werden Pigmentsteine, welche durch Bindung von Bilirubin an Kalzium entstehen, Cholesterinsteine, welche durch eine Cholesterinkristallbildung in der Galle entstehen und sogenannte gemischte Steine, welche gehäuft bei Mukoviszidose beobachtet werden.In den meisten Fällen werden Gallensteine im Rahmen von Sonografien des Abdomens entdeckt, ohne dass sie bis dahin durch Symptome auffielen. Symptomatische Gallensteine manifestieren sich beim Säugling unspezifisch. Erst beim älteren Kind werden kolikartige Bauchschmerzen mit Ausstrahlung in die rechte Schulter beobachtet.Als Komplikationen treten Cholezystitis, die biliäre Pankreatitis und die Choledocholithiasis auf.Während man sich bei asymptomatischen Gallensteinen eher zurückhaltend hinsichtlich einer Therapie verhalten sollte, ist bei symptomatischen Steinen die Choleszystektomie indiziert. Eine Lyse mit Ursodeoxycholsäure ist nur bei einem geringen Anteil der Patienten erfolgversprechend, eine Lithotrypsie ist bei Kindern obsolet.
Gallenwegzysten bei Kindern und Jugendlichen
Authors: Grothues Dirk , Vermehren Jan , Melter Michael , Knoppke Birgit 
Published: June 2020

ZUSAMMENFASSUNGGallenwegzysten sind seltene angeborene Fehlbildungen des Gallenwegsystems, welche zumeist bereits im Kindesalter diagnostiziert werden. Sie sind oft symptomlos, können sich aber auch schon im Kindesalter mit Zeichen einer unklaren zystischen Struktur im rechten Oberbauch, mit Zeichen einer akuten oder chronischen Obstruktion der Gallenwege oder einer Pankreatitis manifestieren. Die am weitesten verbreitete Einteilung der Zysten erfolgt nach Todani, welcher fünf Typen unterscheidet. Typ I und IV stellen dabei die häufigsten Zystenarten dar. Die genaue Beschreibung und Einteilung der Zysten ist von großer Bedeutung, da hiervon die Prognose, aber auch das weitere therapeutische Vorgehen abhängen. Dabei ist es inzwischen allgemein anerkannt, dass Gallenwegzysten eine Präkanzerose darstellen. Die Therapie der Wahl besteht daher in einer möglichst vollständigen Resektion des gesamten extrahepatischen Gallengangsystems mit Anlage einer biliodigestiven Anastomose. Es wird empfohlen, die Operation bereits im Kindesalter durchzuführen, da mit zunehmendem Alter das Risiko einer malignen Entartung signifikant ansteigt, aber auch die Rate an operativen Komplikationen zunimmt.
The impact of COVID-19 pandemic on IBD endoscopic procedures in a high-volume IBD Center
Authors: Lopetuso Loris Riccardo , Scaldaferri Franco , Ianiro Gianluca , Bibbò Stefano , Settanni Carlo Romano , Papa Alfredo , Armuzzi Alessandro , Gasbarrini Antonio , Cammarota Giovanni 
Published: June 2020

Abstract
Background and study aims The COVID-19 pandemic is having a major clinical and also organizational impact on national health care systems, particularly in high-volume hospitals that are utilized for several essential clinical needs. We aimed to analyze the short-term impact of the SARS-CoV-2 pandemic on management of endoscopic procedures in patients with inflammatory bowel disease (IBD).
Patients and methods This was an observational prospective study exploring major clinical and organizational changes in endoscopic management at the IBD Center – CEMAD of the Fondazione Policlinico Gemelli IRCCS, Rome, Italy since the beginning of SARS-CoV-2 pandemic.
Results Our IBD Unit, with up to 1,500 IBD patients receiving biotechnological or experimental therapy, represents a high-volume Italian and European IBD center. Since the beginning of the outbreak, our hospital has been extremely impacted by care related to COVID-19 cases, with a consequent need to dramatically reorganize management of endoscopic procedures for IBD.
Conclusions Outbreak restrictions have significantly impacted the volume of endoscopic activities for IBD. Specific strategies have been designed to guarantee a high level of safety for both patients with IBD and healthcare personnel dedicated to their treatment.
Die Rolle von Psychopathologie und Nosologie in der ‚Precision‘-Psychiatrie
Authors: Schultze-Lutter Frauke , Theodoridou Anastasia 
Published: June 2020

ZusammenfassungPsychopathologie, die wissenschaftliche Erfassung krankhaft veränderten bzw. gestörten Erlebens und Verhaltens, hat für mehr als ein Jahrhundert eine Gestalt für psychiatrische Störungsbilder und damit die Grundlage der psychiatrischen Nosologie gebildet. So schuf sie die Basis für den klinischen und wissenschaftlichen Fortschritt in der modernen Psychiatrie, verlor jedoch in der Folge des technischen Fortschritts zunehmend gegenüber neurobiologischer Forschung an Bedeutung. Obwohl die präzise, qualifizierte psychopathologische Erhebung die Kernkompetenz der Kliniker darstellte, schenken heutige Kurrikula ihrem Training zunehmend weniger Beachtung. Da aber neurobiologische Verfahren ihre diagnostische Überlegenheit noch unter Beweis zu stellen haben, basieren psychiatrische Diagnosen im DSM-5 und ICD-11 weiterhin ausschließlich auf psychopathologischen Definitionen. Jedoch wird deren kategoriale Nosologie durch Fortschritte in der computerisierten Psychiatrie und der zunehmend empfohlenen ‚Precision‘-Psychiatrie infrage gestellt. Die vorliegende Übersichtsarbeit betrachtet die Rollen von Psychopathologie und Nosologie und die aktuelle Debatte um ihre zukünftigen Rollen in einer ‚Precision‘-Psychiatrie – von der Unterstützung neurobiologischer Forschung durch die Zuordnung neurobiologischer Abweichungen zu subjektiven Erlebnisweisen bis zum Zur-Verfügung-Stellen eines Rahmens für die psychiatrische Begegnung. Sie schlussfolgert, dass die heutige Psychiatrie nicht weniger, sondern eine umfassendere, differenziertere Psychopathologie sowie eine erneuerte, am ehesten dimensional ausgelegte Nosologie benötigt, um die Erlebnisweisen der Patienten und professionelles Wissen angemessen zu integrieren.
A Forensic Aspect of Fetal Shoulder Dystocia
Authors: Habek Dubravko , Cerovac Anis 
Published: June 2020

AbstractFetal shoulder dystocia (FSD) is an unpredictable and critical obstetric intrapartum emergency, where an objective problem is the relationship between the mother's pelvis and the child, i. e., an anthropometric disorder of delivery mechanics and dynamics. It is evident that the need to perform other maneuvers indicates the severity of FSD, which in turn correlates with the consequent iatrogenic injury of the fetus and/or mother. FSD is certainly the most controversial forensic obstetric problem, with the most disputes, compensation for damages due to peripartum injury to the child and/or mother, pain suffered, the need for someone else's care, and permanent disability. Suboptimal procedures and inadequate documentation are factors of forensic risk and subsequent litigations. Prevention of FSD is generally not possible, although good antenatal care can sometimes exclude risky cases of FSD, and some rare, chronic intrauterine disorders can result in orthopedic and neurological sequelae, which is especially important in forensic analysis. Because FSD is largely impossible to predict, it must be viewed as an intrapartum acceptable risk. During childbirth, FSD may compromise the safety of the mother and unborn child, therefore education and skills acquisition are necessary for obstetric work. Risk control, proper procedures, and proper documentation, along with good communication with the pregnant women and their families, significantly reduce litigation procedures.
Mütter-Screening in einem COVID-19-Niedrig-Pandemiegebiet: Bestimmung SARS-CoV-2-spezifischer Antikörper bei 401 Rostocker Müttern mittels ELISA und Immunfluoreszenz-Bestätigungstest
Authors: Reisinger Emil C. , von Possel Ronald , Warnke Philipp , Geerdes-Fenge Hilte F. , Hemmer Christoph J. , Pfefferle Susanne , Löbermann Micha , Littmann Martina , Emmerich Petra 
Published: June 2020

ZusammenfassungHintergrund Bei Kindern verläuft die Infektion mit SARS-CoV-2, dem Erreger von COVID-19, in der Regel weniger schwer und häufiger symptomlos als bei Erwachsenen. Kinder können aber diese Infektion u. a. auf vulnerable Erwachsene übertragen. Daher sind zur Zeit Einrichtungen der Kinderbetreuung und Schulen teilweise geschlossen.Methoden Da sich der Infektionsstatus bei Kindern unter 13 Jahren und deren Müttern meist ähnlich darstellt, untersuchten wir bei 401 Rostocker Müttern von Kindern zwischen 1 und 10 Jahren Rachenabstriche auf SARS-CoV-2 und Serumproben auf Antikörper gegen diesen Erreger.Ergebnisse Wir fanden bei keiner der untersuchten Mütter RNA von SARS-CoV-2 im Rachenabstrich. Im ELISA waren IgG-Antikörper in einem Serum positiv, IgA-Antikörper waren in 11 Seren positiv und in 3 Seren grenzwertig. Alle 401 Seren waren im Fluoreszenz-Bestätigungstest (IIFT) mit FITC-markierten IgG-, IgA- und IgM-Antikörpern negativ.Schlussfolgerung Im Untersuchungszeitraum waren bei den getesteten Rostocker Müttern weder RNA von SARS-CoV-2 noch spezifische Antikörper nachweisbar.
Epidural Catheter-Assisted Percutaneous Transforaminal Endoscopic Diskectomy: A Technical Note
Authors: Kim Ki Joon , Jang JeeSoo , Jang Il-Tae 
Published: June 2020

AbstractBackground With advances in techniques and instruments, percutaneous endoscopic transforaminal lumbar diskectomy (PETLD) is now widely used for lumbar disk herniation. Although the indication for PETLD is expanding, the technique still has limitations. To overcome them, we performed the epidural catheter-assisted PETLD described here.Methods A 49-year-old woman had severe radiating pain in a left L5 dermatomal distribution. Magnetic resonance imaging (MRI) revealed left paramedial disk herniation at L4–L5 and a small downward-migrated disk fragment. We performed epidural catheter-assisted PETLD. Mechanical outward pushing and normal saline injection through the epidural catheter were performed for removal of hidden disk remnants. In the second case, a 26-year-old man presented with severe radiating pain in the L5–S1 dermatoms on both sides. MRI revealed massive disk herniation at L4–L5. A unilateral approach was used, and the ruptured disk could be moved using an epidural catheter.Results The patients' pain improved immediately after the procedures. With this method, neural decompression can be performed more easily and effectively.Conclusions Epidural catheter-assisted PETLD has several advantages and can overcome the limitations of conventional PETLD.
Alkylation of Phosphinite/Phosphonite-Boranes via Temporary Protection of the P–H Bond
Authors: Sowa Sylwia , Modzelewski Kamil 
Published: June 2020

A new alkylation protocol for the synthesis of tertiary phosphonite­/phosphinite-boranes is developed. P-Alkylation products are obtained exclusively in moderate to very good yields from easily accessible (1-hydroxy-1-methylethyl)/(1-hydroxy-1-cyclohexyl) phosphonite/phosphinite-boranes upon reaction with a variety of electrophiles under mild conditions. The methodology opens up new synthetic routes for organophosphorus chemistry and offers access to valuable alkyl phosphonite/phosphinite-boranes. In contrast to previously reported oxidative removal–substitution sequences for the preparation of optically active phosphinite-boranes, our protocol provides a one-step procedure that occurs without loss of stereochemical information at phosphorus. This new approach provides a rather advantageous protocol when compared to direct alkylation methods (which may undergo P-epimerization) and occurs in a stereoselective manner even at 0 °C.
Anodic Oxidation as an Enabling Tool for the Synthesis of Natural Products
Authors: Opatz Till , Geske Leander , Sato Eisuke 
Published: June 2020

Electrochemistry provides a valuable toolbox for organic synthesis and offers an appealing, environmentally benign alternative to the use of stoichiometric quantities of chemical oxidants or reductants. Its potential to control current efficiency along with providing alternative reaction conditions in a classical sense makes electrochemistry a suitable method for large-scale industrial transformations as well as for laboratory applications in the synthesis of complex molecular architectures. Even though research in this field has intensified over the recent decades, many synthetic chemists still hesitate to add electroorganic reactions to their standard repertoire, and hence, the full potential of preparative organic electrochemistry has not yet been unleashed. This short review highlights the versatility of anodic transformations by summarizing their application in natural product synthesis.1	Introduction2	Shono-Type Oxidation3	C–N/N–N Bond Formation4	Aryl–Alkene/Aryl–Aryl Coupling5	Cycloadditions Triggered by Oxidation of Electron-Rich Arenes6	Spirocycles7	Miscellaneous Transformations8	Future Prospects
Spinal Cord Stimulation as a Treatment Option for Refractory Chemotherapy-Induced Peripheral Neuropathy: Case Report
Authors: Lopes Arthur , Duarte Kleber , Lins Catarina , Kubota Gabriel , Silva Valquíria , Galhardoni Ricardo , Menezes Luciana Mendes Bahia , Raicher Irina , Teixeira Manoel J. , Andrade Daniel C. 
Published: June 2020

AbstractColorectal cancer is one of the most common oncological diseases. Chemotherapy is usually recommended as an adjuvant treatment for stage-II, -III, and -IV tumors. Approximately 10% of the patients develop neuropathic pain after chemotherapy, and they may remain refractory despite the administration of drugs that are commonly used to treat neuropathic pain. Spinal cord stimulation is a good treatment option for neuropathic pain of the lower limbs, and it should be trialed in patients with chemotherapy-induced peripheral neuropathy. We report the case of a patient with oxaliplatin-induced neuropathy and neuropathic pain refractory to oral medication who was successfully treated by spinal cord stimulation.
Safety and Efficacy of Blood Flow Restriction Therapy after Operative Management of Distal Radius Fractures: A Randomized Controlled Study
Authors: Sgromolo Nicole M. , Cancio Jill M. , Rhee Peter C. 
Published: June 2020

Abstract
Background Blood flow restriction (BFR) therapy is an emerging addition to rehabilitative programs that allows patients to increase strength at lower loads over shorter time periods. Therefore, we conducted a study to evaluate the safety and efficacy of a rehabilitation program using BFR to a traditional rehabilitation protocol following operative fixation of distal radius fractures.
Methods A randomized controlled study was conducted comparing a standardized rehabilitation protocol alone to a combined protocol with the use of BFR therapy in patients treated with volar plate fixation following a displaced distal radius fracture. The same exercises done in the control group were performed by the BFR group with a restrictive tourniquet in place. Patients were followed with serial radiographs to ensure fracture stability. Outcome measures included wrist range of motion, grip strength, pinch strength, visual analog scale (VAS) pain scores at rest and during activity, patient rated wrist evaluation scores (PRWE), and disabilities of the arm, shoulder, and hand scores.
Results Nine patients were randomized and enrolled within the BFR group (n = 5) and control (n = 4) groups. Patients within the BFR group had a significantly greater reduction in pain with activity over the course of the rehabilitation program. Additionally, the BFR group had a significant improvement in PRWE scores during the 8-week rehabilitation program. There was no difference in radiographic measures after initiation of BFR, and all patients tolerated therapy without noted complications.
Conclusion BFR therapy is safe and well tolerated after operatively treated distal radius fractures. The addition of BFR therapy can result in quicker reduction in pain with activity and improvement in patient disability when used early following operative management of a distal radius fracture.
Level of Evidence This is a Level 1, prognostic study.