bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the uptake of tuberculosis preventative therapy for people living with HIV in Namibia: a multiple methods analysis
Authors: Roscoe Clay , Lockhart Chris , de Klerk Michael , Baughman Andrew , Agolory Simon , Gawanab Michael , Menzies Heather , Jonas Anna , Salomo Natanael , Taffa Negussie , Lowrance David , Robsky Katherine , Tollefson Deanna , Pevzner Eric , Hamunime Ndapewa , Mavhunga Farai , Mungunda Helena 
Published: December 2020

Abstract
Background
In 2016, Namibia had ~ 230,000 people living with HIV (PLHIV) and 9154 new tuberculosis (TB) cases, including 3410 (38%) co-infected cases. TB preventative therapy (TPT), consisting of intensive case finding and isoniazid preventative therapy, is critical to reducing TB disease and mortality.

Methods
Between November 2014 and February 2015, data was abstracted from charts of PLHIV enrolled in HIV treatment. Fifty-five facilities were purposively selected based on patient volume, type and location. Charts were randomly sampled. The primary outcome was to estimate baseline TPT in PLHIV, using nationally weighted proportions. Qualitative surveys were conducted and summarized to evaluate TPT practices and quantify challenges encountered by health care workers (HCW).

Results
Among 861 PLHIV sampled, 96% were eligible for TPT services, of which 87.1% were screened for TB at least once. For PLHIV eligible for preventative therapy (646/810; 82.6%), 45.4% (294/646) initiated therapy and 45.7% (139/294) of those completed therapy. The proportion of eligible PLHIV completing TB screening, initiating preventative therapy and then completing preventative therapy was 20.7%. Qualitative surveys with 271 HCW identified barriers to TPT implementation including: lack of training (61.3% reported receiving training on TPT); misunderstandings about timing of TPT initiation (46.7% correctly reported TPT should be started with antiretroviral therapy); and variable screening practices and responsibilities (66.1% of HCWs screened for TB at every encounter). Though barriers were evident, 72.2% HCWs surveyed described their clinical performance as very good, often placing responsibility of difficulties on patients and downplaying challenges like staff shortages and medication stock outs.

Conclusions
In this study, only 1 in 5 eligible PLHIV completed the TPT cascade in Namibia. Lack of training, irregularities with TB screening and timing of TPT, unclear prescribing and recording responsibilities, and a clinical misperception may have contributed to suboptimal programmatic implementation. Addressing these challenges will be critical with continued TPT scale-up.
Trends in contraceptive use, unmet need and associated factors of modern contraceptive use among urban adolescents and young women in Guinea
Authors: Sidibé Sidikiba , Delamou Alexandre , Camara Bienvenu Salim , Dioubaté Nafissatou , Manet Hawa , El Ayadi Alison M. , Benova Lenka , Kouanda Seni 
Published: December 2020

Abstract
Background
In Guinea, high fertility among adolescents and young women in urban areas remains a public health concern. This study describes trends in contraceptive use, unmet need, and factors associated with the use of modern family planning (FP) methods among urban adolescents and young women in Guinea.

Methods
We used four Guinea Demographic and Health Surveys (DHS) conducted in 1999, 2005, 2012, and 2018. Among urban adolescents and young women (15–24 years), we examined trends over time in three key indicators: 1. Modern Contraceptive use, 2. Unmet need for FP and 3. Modern contraceptive use among those in need of FP (demand satisfied). We used multivariable logistic regression to examine association between socio-demographic factors and modern FP use on the most recent DHS dataset (2018).

Results
We found statistically significant changes over the time period examined with an increase in modern contraceptive use (8.4% in 1999, 12.8% in 2018, p < 0.01) and demand satisfied (29.0% in 1999, 54.1% in 2018, p < 0.001), and a decrease in unmet need for FP (15.8% in 1999, 8.6% in 2018, p < 0.001). Factors significantly associated with modern FP use were; young women aged 20–24 years (AOR 2.8, 95% CI: 1.9–4.1), living in urban areas of Faranah (AOR: 2.6, 95% CI: 1.1–6.5) and Kankan (AOR: 3.6, 95% CI: 1.7–7.8), living in households in the middle (AOR: 7.7, 95% CI: 1.4–42.2) and richer wealth quintiles (AOR: 6.3, 95% CI: 1.0–38.1). Ever-married women (AOR: 0.5, 95% CI: 0.3–0.9) were less likely to use modern FP methods than never married as were those from the Peulh (0.3, 95% CI: 0.2–0.4) and Malinke (0.5, 95% CI: 0.3–0.8) ethnic groups compared to Soussou ethnic group.

Conclusion
Despite some progress, efforts are still needed to improve FP method use among urban adolescent and young women. Age, administrative region, wealth index, marital status, and ethnic group are significantly associated with modern FP use. Future policies and interventions should place emphasis on improving adolescents’ reproductive health knowledge, increasing FP availability and strengthening provision. Efforts should target adolescents aged 15–19 years in particular, and address disparities between administrative regions and ethnic groups, and health-related inequalities.
Association between social trust and the risk of cardiovascular disease in older adults in Korea: a nationwide retrospective cohort study
Authors: Hwang Seo Eun , Choi Seulggie , Kim Kyuwoong , Lee Jong-Koo , Oh Juhwan , Park Sang Min 
Published: December 2020

Abstract
Background
Although social capital has been shown to be one of the important social determinants of health, the association between social trust and the risk of cardiovascular disease (CVD) is not clear yet. We aimed to investigate the association of social trust with CVD risk using a large Korean population based data.

Methods
The data of this study was derived from the Korean National Health Insurance Service database. Community-level social trust was determined from the Korean Community Health Survey. The study population consisted of 2,156,829 participants. According to social trust index measured in the area of residence during 2011, participants were followed-up from 1 January 2012 to 31 December 2016. Multivariate Cox proportional hazards regression was used to determine the adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for CVD risk according to quintiles of social trust.

Results
Compared to participants with the lowest quintile of social trust, those within the highest quintile had lower risk for CVD (aHR 0.91, 95% CI = 0.89 to 0.93), CHD (aHR 0.92, 95% CI = 0.89 to 0.95), and stroke (aHR 0.90, 95% CI = 0.87 to 0.93). The risk-reducing association of high social trust on CVD risk was preserved after additional adjustments for lifestyle behaviors including smoking, alcohol consumption, and physical activity.

Conclusion
Higher social trust was associated with reduced risk of CVD even after considering lifestyle behaviors. Social trust in a community level is an important determinant of CVD and enhancing social trust may lead to reduced risk of CVD.
Epidemiology of pediatric femur fractures in children: the Swedish Fracture Register
Authors: Engström Zandra , Wolf Olof , Hailer Yasmin D. 
Published: December 2020

Abstract
Background
Although femur fractures in children are rare, they are the most common fractures in need of hospitalization. We sought to describe the epidemiology and treatment of pediatric femur fractures recorded in the Swedish Fracture Register (SFR). We also studied the relationship between femur fractures, age, sex, fracture pattern, injury mechanism, seasonal variation and treatment.

Methods
This nationwide observational register study was based on the pediatric part of the SFR. We included all patients < 16 years of age who were registered in the SFR from 2015 to 2018.

Results
Of the 709 femur fractures, 454 (64%) occurred in boys. Sixty-two of these fractures were proximal (9%), 453 shaft (64%) and 194 distal (27%). A bimodal age distribution peak was observed in boys aged 2–3 and 16–19 years. In contrast, the age distribution among girls was evenly distributed. Younger children were mainly injured by a fall, whereas older children sustained their fracture because of traffic accidents. Non-surgical treatment prevailed among younger children; however, prevalence of surgical treatment increased with age.

Conclusions
We found a lower ratio between boys and girls (1.8:1) compared to earlier studies. The bimodal age distribution was seen only in boys. Falls were the most common injury in younger children, whereas traffic-related accidents were the most common in adolescents. With age, there was a corresponding increase in surgical treatment.
Higher aggrecan 1-F21 epitope concentration in synovial fluid early after anterior cruciate ligament injury is associated with worse knee cartilage quality assessed by gadolinium enhanced magnetic resonance imaging 20 years later
Authors: Neuman Paul , Larsson Staffan , Lohmander L. Stefan , Struglics André 
Published: December 2020

AbstractBackgroundTo investigate if cartilage related biomarkers in synovial fluid are associated with knee cartilage status 20 years after an anterior cruciate ligament (ACL) injury.MethodsWe studied 25 patients with a complete ACL rupture without subsequent ACL reconstruction or radiographic knee OA. All had a delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) 20 years after the ACL injury, using the T1 transverse relaxation time in the presence of gadolinium (T1Gd) which estimates the concentration of glycosaminoglycans in hyaline cartilage. Synovial fluid samples were aspirated acutely (between 0 and 18 days) and during 1 to 5 follow up visits between 0.5 and 7.5 years after injury. We quantified synovial fluid concentrations of aggrecan (epitopes 1-F21 and ARGS), cartilage oligomeric matrix protein, matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by immunoassays, and sulfated glycosaminoglycans by Alcian blue precipitation. Western blot was used for qualitative analyses of aggrecan fragments in synovial fluid and cartilage samples.ResultsWestern blot indicated that the 1-F21 epitope was located within the chondroitin sulfate 2 region of aggrecan. Linear regression analyses (adjusted for age, sex, body mass index and time between injury and sampling) showed that acute higher synovial fluid 1-F21-aggrecan concentrations were associated with shorter T1Gd values 20 years after injury, i.e. inferior cartilage quality (standardized effects between − 0.67 and − 1.0). No other statistically significant association was found between molecular biomarkers and T1Gd values.ConclusionHigher acute synovial fluid 1-F21-aggrecan concentrations in ACL injured patients, who managed to cope without ACL reconstruction and were without radiographic knee OA, were associated with inferior knee cartilage quality assessed by dGEMRIC 20 years after injury.
Digital tools as promoters for person-centered care practices in chronic care? Healthcare professionals’ experiences from rheumatology care
Authors: Granström Emma , Wannheden Carolina , Brommels Mats , Hvitfeldt Helena , Nyström Monica E. 
Published: December 2020

Abstract
Background
Person-centered care (PCC) emphasize the importance of supporting individuals’ involvement in care provided and self-care. PCC has become more important in chronic care as the number of people living with chronic conditions is increasing due to the demographic changes. Digital tools have potential to support interaction between patients and healthcare providers, but empirical examples of how to achieve PCC in chronic care and the role of digital tools in this process is limited. The aim of this study was to investigate strategies to achieve PCC used by the healthcare professionals at an outpatient Rheumatology clinic (RC), the strategies’ relation to digital tools, and the perceived impact of the strategies on healthcare professionals and patients.

Methods
A single case study design was used. The qualitative data consisted of 14 semi-structured interviews and staff meeting minutes, covering the time period 2017–2019. The data were analyzed using conventional content analysis, complemented with document analyses.

Results
Ten strategies on two levels to operationalize PCC, and three categories of perceived impact were identified. On the individual patient level strategies involved several digital tools focusing on flexible access to care, mutual information sharing and the distribution of initiatives, tasks, and responsibilities from provider to patients. On the unit level, strategies concerned involving patient representatives and individual patients in development of digital services and work practices. The roles of both professionals and patients were affected and the importance of behavioral and cultural change became clear.

Conclusions
By providing an empirical example from chronic care the study contributes to the knowledge on strategies for achieving PCC, how digital tools and work practices interact, and how they can affect healthcare staff, patients and the unit. A conclusion is that the use of the digital tools, spanning over different dimensions of engagement, facilitated the healthcare professionals’ interaction with patients and the patients’ involvement in their own care. Digital tools complemented, rather than replaced, care practices.
New biostratigraphical data (calcareous nannofossils, ammonites) and Early to Late Barremian transition in the Urgonien Jaune facies and Marnes de la Russille complex of the Swiss Jura Mountains
Authors: De Kaenel Eric , Mojon Pierre-Olivier , Pictet Antoine 
Published: December 2020

AbstractIn the central Jura Mountains (Western Switzerland), the Urgonien Jaune (UJ) facies with the Marnes de la Russille beds (MRu) have provided very rich nannofloras associated with very rare Tethyan ammonites. A late Early Barremian nannoflora of the Mid-Barremian Event (MBE, following a regional tectonic event of an earliest Barremian synsedimentary tectonic crisis) was found in MRu of the lower UJ and includes 42 genera with 90 species. Among them, Biscutum jurensis De Kaenel, n. sp., Flabellites eclepensensis De Kaenel, n. sp., Palaeopontosphaera giraudii De Kaenel, n. sp., Rhagodiscus buisensis De Kaenel, n. sp., and Vagalapilla rutledgei De Kaenel, n. sp., are recognized as five new species. This nannoflora is a mixture of Boreal and Tethyan taxa with 20 nannofossil markers (Assipetra terebrodentarius, Broinsonia galloisii, Calcicalathina oblongata, Cyclagelosphaera rotaclypeata, Diloma placinum, Ethmorhabdus hauterivianus, Flabellites eclepensensis, Gorkaea pseudoanthophorus, Nannoconus abundans, Nannoconus pseudoseptentrionalis, Palaeopontosphaera giraudii, Palaeopontosphaera pinnata, Placozygus howei, Placozygus reticulatus, Reinhardtites scutula, Rhagodiscus buisensis, Rhagodiscus eboracensis, Tegulalithus septentrionalis, Tubodiscus jurapelagicus, Zeugrhabdotus moulladei) indicating very precisely the nannofossil Zones LK19 (Boreal)–NC5D (Tethyan) as well as the Elegans (Boreal) and Moutonianum (Tethyan) ammonite Zones of the latest Early Barremian. The ammonites in the basal UJ facies of Early Barremian age are reworked Lyticoceras claveli (Nodosoplicatum Zone, Early Hauterivian) and reworked Cruasiceras cf. cruasense (Sayni Zone, early Late Hauterivian), and Pseudometahoplites sp. juv. (Compressissima to Vandenheckii Zones, Early to Late Barremian transition) from the basal MRu. The new palaeontological and sequential results of this study allow a revision of previous data from Godet et al. (2010) precisely assigning a Barremian age to the MRu of the central Jura Mountains (Tethyan Compressissima to lower Sartousiana and Boreal uppermost Fissicostatum to middle Denckmanii ammonite Zones, Boreal LK20B-LK19-LK18 and Tethyan NC5D nannofossil Zones), within the Early to Late Barremian UJ (Tethyan Hugii to lower Sartousiana and Boreal Rarocinctum to middle Denckmanii ammonite Zones, Boreal LK20C to LK18 and Tethyan NC5C-NC5D nannofossil Zones) and below the Late Barremian Urgonien Blanc facies (Tethyan Sartousiana ammonite Zone). ZooBank LSID: urn:lsid:zoobank.org:pub:DDE0EF8B-AC43-4DFC-A029-64224C5D37A7.
A rational emotive behavior therapy-based intervention for binge eating behavior management among female students: a quasi-experimental study
Authors: Yang Jiwon , Han Kuem Sun 
Published: December 2020

Abstract
Background
Binge eating behavior is highly likely to progress to an eating disorder, with female students particularly at risk.

Objective
This study aimed to verify the effect of a binge eating behavior management program, based on rational emotive behavior therapy (REBT), on binge eating behavior and related cognitive and emotional factors among female college students.

Method
The study, conducted from November 1 to December 2, 2016, involved a pretest-posttest design and nonequivalent control group. The sample included 24 and 22 first- to third-year students, from a college in South Korea, in the experimental and control groups, respectively. Data were collected using self-esteem, covert narcissism, perfectionism, body dissatisfaction, anxiety, depression, and binge eating scales and analyzed via frequency analysis, χ2 tests, t tests, and analysis of covariance.

Results
The results indicated that the REBT-based binge eating behavior management program exerted positive effects on participants’ self-esteem, reducing covert narcissism, body dissatisfaction, anxiety, depression, and binge eating. However, there was no significant difference in perfectionism, although the experimental group’s mean score decreased from pretest to posttest.

Conclusions
Based on the results, the program was considered to be effective, and is expected to be useful in preventing the development of eating disorders among female college students by treating binge eating behavior and related cognitive and emotional factors. This intervention could ultimately contribute to the improvement of female college students’ health and quality of life.
President's Page
Authors: Marfurt Kurt J. 
Published: December 2020

For me, the SEG Annual Meeting is our Society's prime venue for sharing technology, learning about new products and services, meeting old friends, and forging new alliances. For SEG as an organization, it is not only all of those things but also the largest expense and the biggest revenue generator of the year. Therefore, as the transmission of COVID-19 increased, it was with considerable organizational anxiety that SEG moved from the traditional in-person convention, to a hybrid convention, to the fully digital convention held from 11–16 October 2020. Although the complete assessment of the meeting will take some time for our organization to construct, I feel qualified to provide a limited assessment of the pros and cons from the perspective of researchers, academics, and students.
Improving prescribing of extended prophylaxis for venous thromboembolism at discharge in patients who underwent surgery for colorectal cancer
Authors: Ong Chea Tze , Leung Edmund , Shah Adarsh P 
Published: December 2020

Aims/Background Prophylaxis at discharge is important in mitigating venous thromboembolism events from colorectal cancer and major abdominopelvic surgery, both of which are risk factors for venous thromboembolism. Foundation doctors frequently rotate between departments, and so rely on departmental induction and/or handing down of knowledge to prescribe extended venous thromboembolism prophylaxis upon discharge. Methods A retrospective audit of all patients who underwent surgery for colorectal cancer at The County Hospital, Hereford, between 1 August 2018 and 31 August 2019, was undertaken to assess departmental compliance with guidance from the National Institute for Health and Care Excellence. Results A total of 181 patients underwent elective surgery and 29 patients had emergency surgery. The initial audit revealed a cyclical 4-monthly decline that coincided with foundation doctors' rotations. Six multidisciplinary interventions were implemented. Reaudit demonstrated 100% compliance with prescribing of extended venous thromboembolism prophylaxis at discharge. No venous thromboembolism events 30 days post operation were noted. Conclusions A multidisciplinary approach involving educating health professionals about the importance of extended venous thromboembolis prophylaxis in patients who have undergone surgery for colorectal cancer can be effective in improving compliance with prescribing practices at discharge.
December 2020 Pulmonary Case of the Month: Resurrection or Medical Last Rites?
Authors:   Mayo Clinic Arizona, Scottsdale, AZ USA, Wesselius Lewis 
Published: December 2020

No abstract available. Article truncated after the first page. History of Present Illness An 88-year-old man who has been short of breath and febrile up to 101.5° F for the past day presented on October 20, 2020. He has no known sick contacts or exposure to COVID-19. PMH, SH, and FH •	No reported pulmonary history although he had a Xopenex MDI which he rarely used. •	Coronary artery disease with prior coronary artery bypass grafting (1978); multiple subsequent stents; chronic atrial fibrillation; pacemaker (Micra) •	Stage 3-4 CKD (creatinine 1.95) •	Chronically on warfarin Physical Examination •	Temp 37.3, Sat 92% on RA, 95% on 2 lpm, •	Lungs: Few crackles in right upper chest •	CV: regular, no murmur •	Ext: 1 to 2+ edema (chronic, uses TED hose) Which of the following is/are the most likely diagnosis? 1.	Community-acquired pneumonia 2.	Congestive heart failure 3.	COVID-19 4.	1 and 3 5.	Any of the above …
Multisectoral approach to achieve canine rabies controlled zone using Intervention Mapping: Preliminary results
Authors: Gautam Vaishali , Bhardwaj Pankaj , Saxena Deepak , Kumar Nitesh , S. Dileepan 
Published: December 2020

BackgroundAnnually, in India, millions of dog bite cases occur; most of them are inflicted by a stray dog. There are over 25 million dogs in the country. The rate of stray dog vaccination is suboptimal in India. This study aims to develop an intervention strategy, using Intervention Mapping framework, tailored for the target community to achieve canine rabies controlled zone.MethodologyThis is an exploratory, cross-sectional study conducted at a tertiary care Medical Institute at Jodhpur, Rajasthan, India, from 2018–2019. The semi-structured, In-Depth Discussion was conducted with a multidisciplinary planning group comprising of members from veterinary, health, and administrative sectors. The In-Depth Discussion focused on knowledge regarding complete stray dog vaccination schedule, self-efficacy (to prevent dog bites), challenges, and barriers faced by residents to achieve canine rabies controlled zone. Further, discussion with veterinary stakeholders focused on challenges faced for rigorous implementation of stray dog vaccination and sterilization.ResultsIn-Depth Discussion revealed the following challenges: Lack of participation by the study population for canine vaccination, incomplete knowledge about annual canine vaccination schedule, lack of understanding of dog gestures, lack of infrastructure and resources at veterinary hospitals. The majority of the dogs in the study area were stray dogs that were partially or non-vaccinated and non-sterilized. An intersectoral collaboration was achieved between the community members, veterinary stakeholders both private and Non-Governmental organisations, and heath sector. Following which 35 (76.0%) stray dogs were vaccinated, and 17 (35.4%) were sterilized with community support. Burden of dog bite cases also decreased. The stray dog density map was prepared, and community engagement activity on dog gestures was conducted.ConclusionThe present study demonstrates the feasibility of achieving canine rabies controlled zone. When implemented in a phase-wise manner across all Medical and Residential complex, this strategy would ensure achieving canine rabies controlled zone through multi-stakeholder engagement.