bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Systematic Medical Appraisal Referral and Treatment Mental Health Project: Quasi-Experimental Study to Evaluate a Technology-Enabled Mental Health Services Delivery Model Implemented in Rural India
Authors: Maulik Pallab K , Devarapalli Siddhardha , Kallakuri Sudha , Bhattacharya Amritendu , Peiris David , Patel Anushka 
Published: December 2019

Background
Although around 10% of Indians experience depression, anxiety, or alcohol use disorders, very few receive adequate mental health care, especially in rural communities. Stigma and limited availability of mental health services contribute to this treatment gap. The Systematic Medical Appraisal Referral and Treatment Mental Health project aimed to address this gap.

Objective
This study aimed to evaluate the effectiveness of an intervention in increasing the use of mental health services and reducing depression and anxiety scores among individuals at high risk of common mental disorders.

Methods
A before-after study was conducted from 2014 to 2019 in 12 villages in Andhra Pradesh, India. The intervention comprised a community antistigma campaign, with the training of lay village health workers and primary care doctors to identify and manage individuals with stress, depression, and suicide risk using an electronic clinical decision support system.

Results
In total, 900 of 22,046 (4.08%) adults screened by health workers had increased stress, depression, or suicide risk and were referred to a primary care doctor. At follow-up, 731 out of 900 (81.2%) reported visiting the doctor for their mental health symptoms, compared with 3.3% (30/900) at baseline (odds ratio 133.3, 95% CI 89.0 to 199.7; P<.001). Mean depression and anxiety scores were significantly lower postintervention compared with baseline from 13.4 to 3.1 (P<.001) and from 12.9 to 1.9 (P<.001), respectively.

Conclusions
The intervention was associated with a marked increase in service uptake and clinically important reductions in depression and anxiety symptom scores. This will be further evaluated in a large-scale cluster randomized controlled trial.
Blockchain-Authenticated Sharing of Genomic and Clinical Outcomes Data of Patients With Cancer: A Prospective Cohort Study
Authors: Glicksberg Benjamin Scott , Burns Shohei , Currie Rob , Griffin Ann , Wang Zhen Jane , Haussler David , Goldstein Theodore , Collisson Eric 
Published: December 2019

Background
Efficiently sharing health data produced during standard care could dramatically accelerate progress in cancer treatments, but various barriers make this difficult. Not sharing these data to ensure patient privacy is at the cost of little to no learning from real-world data produced during cancer care. Furthermore, recent research has demonstrated a willingness of patients with cancer to share their treatment experiences to fuel research, despite potential risks to privacy.

Objective
The objective of this study was to design, pilot, and release a decentralized, scalable, efficient, economical, and secure strategy for the dissemination of deidentified clinical and genomic data with a focus on late-stage cancer.

Methods
We created and piloted a blockchain-authenticated system to enable secure sharing of deidentified patient data derived from standard of care imaging, genomic testing, and electronic health records (EHRs), called the Cancer Gene Trust (CGT). We prospectively consented and collected data for a pilot cohort (N=18), which we uploaded to the CGT. EHR data were extracted from both a hospital cancer registry and a common data model (CDM) format to identify optimal data extraction and dissemination practices. Specifically, we scored and compared the level of completeness between two EHR data extraction formats against the gold standard source documentation for patients with available data (n=17).

Results
Although the total completeness scores were greater for the registry reports than those for the CDM, this difference was not statistically significant. We did find that some specific data fields, such as histology site, were better captured using the registry reports, which can be used to improve the continually adapting CDM. In terms of the overall pilot study, we found that CGT enables rapid integration of real-world data of patients with cancer in a more clinically useful time frame. We also developed an open-source Web application to allow users to seamlessly search, browse, explore, and download CGT data.

Conclusions
Our pilot demonstrates the willingness of patients with cancer to participate in data sharing and how blockchain-enabled structures can maintain relationships between individual data elements while preserving patient privacy, empowering findings by third-party researchers and clinicians. We demonstrate the feasibility of CGT as a framework to share health data trapped in silos to further cancer research. Further studies to optimize data representation, stream, and integrity are required.
Tipe tubuh (somatotype) dengan sindrom metabolik pada wanita dewasa non-obesitas usia 25 – 40 tahun
Authors: Kusumaningnastiti Betsi , Probosari Enny , Dieny Fillah Fithra , Fitranti Deny Yudi 
Published: December 2019

Body type (somatotype) with metabolic syndrome among non-obese woman aged 25-40 years oldBackground: The prevalence of central obesity was found high in women, not only in obese individuals but also occur in non-obese individuals or metabolically obese normal weight (MONW). Endomorph marked by higher fat mass, which will lead to metabolic disorders.Objective: This study aimed to describe the correlation of somatotype with metabolic syndrome in a non-obese woman.Methods: Cross-sectional observational study, subjects were selected using purposive sampling involving 46 women 25-40 years old with BMI 18.5-24.9 kg/m2 in several offices in the City of Semarang, consist of Balai Besar Teknologi Pencegahan dan Pencemaran Industri, Dinas Pekerjaan Umum, and Dinas Perindustrian dan Perdagangan Central Java. Somatotype data is measured in three components, namely endomorph, mesomorph, and ectomorph. The resulting value of each component is calculated using the Heath-Carter formula. Triglycerides, HDL, and fasting blood glucose measured by enzymatic colorimetric methods. Blood pressure measured by aneroid sphygmomanometer. Syndrome metabolic was defined as metabolic syndrome risk score (cMetS). Data were analyzed by Rank Spearman and Pearson.Results: The subject's body type is endomorph as much as 91.3% and ectomorph-endomorph (8.7%). Central obesity (50%), low HDL levels (28%), hypertriglyceridemia (2%), normal GDP levels (100%), hypertension (15%), metabolic syndrome (13%), and metabolic pre-syndromes (47, 8%) found in the subject of this study. There were correlation between endomorph (p=0.005; r=0.4) and ectomorph (p=0.000; r=-0.53) with waist circumference. There was a significant correlation between endomorph with metabolic syndrome risk score (p=0.05; r=0.129).Conclusions: Endomorph was associated with a metabolic syndrome risk score. Higher endomorph tends to have higher metabolic syndrome risk scores.
Malnutrisi rumah sakit dan asuhan nutrisi pediatrik di Rumah Sakit Hasan Sadikin Bandung
Authors: Hafsah Tisnasari , Prawitasari Titis , Djais Julistio Tryoga Budhiawan 
Published: December 2019

Hospital malnutrition and pediatric nutrition care in Hasan Sadikin Hospital BandungBackground: Malnutrition during hospitalization delays the recovery of children with acute or chronic illnesses. The Pediatric Nutrition Care (PNC) can improve nutritional support and reduce the prevalence of hospital malnutrition.Objectives: This study was done to find evidence of hospital malnutrition and to evaluate the nutrition care in the pediatric ward of Dr. Hasan Sadikin Hospital, Bandung. Methods: We evaluated malnutrition by comparing body weight change between the first day of admission and at hospital discharge to the length of hospitalization. Screening for malnutrition risk was done using modified Pediatric Yorkhill Malnutrition Screening (mPYMS). Score≥2 was determined as high risk. The PNC process was evaluated by a focused group discussion with PNC-associated pediatric ward personnel.Results: From February-March 2016, 760 patients were admitted to the pediatric ward, of which 111(14.6%) were included in the study. An mPYMS score of ≥2 was found in 69(62.2%) of the patients. During hospitalization, body weight decreased in 23(20.7%) patients, 10(9.0%) of whom were defined as hospital malnutrition. Among these, seven had an mPYMS score≥2. PNC was performed in patients with an mPYMS score≥2 by dietitians who also provided a standardized nutrition care process following American Dietetic Association recommendation. However, a dedicated multidisciplinary PNC team was absent and the nutrition and metabolic disease division was consulted only in a few cases. Performing consistent monitoring and evaluation of PNC was also found to be difficult. Conclusions: Hospital malnutrition may be prevalent among pediatric patients in Dr. Hasan Sadikin Hospital, Bandung. Improving PNC services may reduce this prevalence.
Penanggulangan depresi lansia pascaerupsi Gunung Merapi melalui permainan humor berbasis kearifan budaya lokal pada kader yandu lansia
Authors: Sumarni Sumarni , Triwirasto Triwirasto , Kusumadewi Andrian Fajar , Yuliani Santi , Dwi Dwi , Kusumaningrum Nanda 
Published: December 2019

Mental health of elderly is a main priority which should be concerned of, in order to provide strength to obtain welfare in old age. Merapi eruption was a natural disaster that provided long-term psychological effects on elderly survivors. It is necessary to be handled with continuous support related to depression and life quality of elderly after Merapi eruption by providing training on humor games based on local cultural wisdom and management of depression in elderly in the manner of social spiritual to the cadres of integrated services for elderly in Hunian Tetap (Huntap) Kuwang, Cangkringa, Sleman, Daerah Istimewa Yogyakarta (DIY). Data used in this research was secondary data taken from community service that conducted in May - September 2014. The community service involved 30 cadres of integrated services for elderly and 45 elderly in Huntap Kuwang. Tools used in this research were module of local wisdom games completed with its equipment and module of early detection and coping with depression. The data were presented in descriptive quantitative and qualitative. After being given training on humor games based on local wisdom, there were increased average score on cadres’ knowledge of humor games based on local wisdom (from 66.4 to 93.2.) and skill (from 64.1 to 87.6,) as well as knowledge of early detection of depression (from 47.6 to 84.4) and skill of social support providing (from 35.3 to 80.8). There were declining trend of depression in elderly from 36 people before training to 17 people after the training of humor games based on local wisdom and spiritual social support. Training on humor games based on local wisdom and early detection of depressive tendencies along with the coping to the cadres of integrated services can reduce depressive tendencies and improve life quality of elderly in Huntap Kuwang, Cangkringan, Sleman, DIY.
Promoting non-communicable disease risks in rural area: a Community and Family Health Care - inter professional education (CFHC-IPE) activity
Authors: Sangun Diannisa Ikarumi Enisar , Nugrahani Dea Aryas , Anindya Khansa , Kuntolowati Niken 
Published: December 2019

Health is an aspect that could be viewed from various age groups and factors. Risk factors found during Community and Family Health Care-Inter Professional Education visits in Pondok 2, Widodomartani, Ngemplak are the habits of people who still lacking in controlling excessive consumption of sugar, salt, and oily foods. These may lead to many problems such as hypertension, diabetes mellitus and hypercholesterolemia. Based on the problem, our group held the community service activities focusing on health screening, particularly on the measurement of blood pressure, random blood glucose, and total cholesterol level. This activity aims to screen the community health condition and to raise health awareness and understanding. Therefore, people may start to take action improving their lifestyle in order to maintain their long term health status. This research is a retrospective study using secondary data obtained from health examination records at the time of community service. The health check-up was conducted on May 4, 2019. We utilize mannual mercury sphygmomanometer for blood pressure measurement and automatic skin prick test device for random blood glucose and total cholesterol level. During the health examination, we also counsel the subjects about healthy lifestyle. Sixteen people from the targeted community attended the activity. Half of the people had normal blood pressure; 1 person pre-hypertension; 4 persons stage I hypertension, and 3 persons stage II hypertension. For random blood glucose measurement, only 1 resulted in high random blood glucose whilst others were within normal limit. Total cholesterol level was examined to 9 people with history of hypercholesterolemia with the following results; 2 people had high level, 2 people had borderline-high level ,and the rest had normal level. Most of the people within the community had good health status. This kind of activity can be routinely conducted not only to screen community health status but also to promote health awareness.
CIRCULATING SERUM ADIPONECTIN AND OXIDATIVE STRESS BIOMARKERS IN PREDIABETES AND TYPE 2 DIABETES MELLITUS PATIENTS
Authors: RACHNA SHARMA  , SATYANARAYANA P  , PALLAVI ANAND  , SHRAWAN KUMAR  
Published: December 2019

Objectives: Adipocytokines and oxidative stress have been independently studied in various morbidities, but their interrelationship in mediating insulin resistance and type 2 diabetes mellitus is still unclear. Thus, the present study was aimed at evaluating malondialdehyde (MDA) levels in pre-diabetes and diabetics and correlating it with adiponectin levels.
Methods: Fifty controls, 50 pre-diabetic, and 50 diabetic patients were enrolled. Plasma MDA, uric acid, and adiponectin were measured in the blood samples. Serum MDA adiponectin was analyzed by enzyme-linked immunosorbent assay and uric acid was analyzed by uricase method.
Results: Pre-diabetic and diabetic patients had higher levels of MDA and uric acid, while the level of adiponectin was low compared to controls. Correlation of MDA was positive with uric acid but negative with adiponectin in diabetic patients. Likewise, adiponectin and uric acid were also correlated negatively. In pre-diabetes, adiponectin was significantly and negatively correlated with MDA and uric acid.
Conclusions: Pre-diabetic and diabetic patients have increased oxidative stress, which is also linked with adipokine abnormalities. From this study, we observed that oxidative stress suppresses adiponectin production which is the protective adipokine in hyperglycemia. Thus, oxidative stress may serve as an indicator or target for in the control of hyperglycemic stress.
ANTIBACTERIAL PROPERTY AND MOLECULAR DOCKING STUDIES OF METHANOLIC FUNGAL PHYTOCHEMICALS OF CLAVICEPS PURPUREA INFECTED TO BAJRA (PENNISETUM GLAUCUM) CROP
Authors: LOKESH ST  , THIPPESWAMY B  , RAVIKUMAR S  
Published: December 2019

Objective: The objective of this study is to study the antibacterial activity, minimum inhibitory concentration, preliminary phytochemical studies, molecular docking studies, and high-resolution liquid chromatography mass spectrometer (HR-LCMS) analysis of the methanol fungal extract of Claviceps purpurea.
Methods: Mass production of the fungal mat of C. purpurea was established on potato dextrose broth medium. The dried methanol extract of fungus was subjected to HR-LCMS analysis; antibacterial screening of the extract was carried out against pathogenic bacteria. Molecular docking study of HR-LCMS identified compounds was performed by docking with bacterial enzyme DNA gyrase.
Results: HR-LCMS analysis of methanol extract of C. purpurea fungus shows that the compounds arecoline, benperidol, felbamate, solanidine, and triparanol as the major constituents. The antibacterial screening of methanol extract of fungus against bacterial pathogens showed a significant bactericidal activity against the strains Pseudomonas aeruginosa (14.40±0.04 mm), Xanthomonas campestris (13.60±0.06 mm), Escherichia coli (13.40±0.06 mm), Salmonella Typhi (11.50±0.05 mm), Staphylococcus aureus (11.37±0.04 mm.), and as matched to the standard drug ciprofloxacin. The molecular docking of triparanol against the bacterial enzyme DNA gyrase showed good binding affinity of −6.2 kcal/mol, good drug likeness (7.3767), 2 hydrogen bonds, and hydrophobic interaction with 8 amino acid residues so that triparanol shows good inhibitor as compared to other 4 compounds.
Conclusion: Methanol fungal extract of C. purpurea showed significant antibacterial activity against pathogenic bacteria. Triparanol is the major compound present in C. purpurea fungus which showed good inhibitory activity against bacterial enzyme DNA gyrase. The methanol extract of C. purpurea fungus displayed a good antibacterial drug.
THEORETICAL APPROACH ON TARGETING PLANT FUNGAL PATHOGENIC PROTEINS AGAINST NATURALLY ISOLATED COMPOUNDS FROM CHITINIPHILUS SHINANONENSIS
Authors: S KRITHIKA , C CHELLARAM 
Published: December 2019

Objective: The objective of this study was to find the potency and bioefficacy of Asiatic acid and triterpene against four different plant fungal pathogens using a structure-based drug designing approach.
Methods: The pathogenic fungus which causes a dreadful effect on plants is reviewed from literature study, and its three-dimensional structures are retrieved from the protein data bank database. On the other hand, ligands are prepared. Finally, prepared fungal drug targets are docked with naturally isolated compounds using AutoDock tools.
Results: Both compounds Asiatic acid and triterpene structures are complementary to bind at the active site of four different drug targets. Comparatively, it is more favorable for Avr2 effector protein from Fusarium oxysporum with Ki value of 126.60 μM, 1.76 μM, and dock score value of −5.32 kcal/mol and −7.85 kcal/mol for Asiatic acid and triterpene, respectively. Thus, interaction analysis was carried out only for these protein-ligand complexes.
Conclusion: The computational biology study states that these two compounds can be the lead candidate for treating disease caused by plant fungal pathogen F. oxysporum. However, further study has to be done in vitro and in vivo to prove its same efficacy.
FABRICATION AND EVALUATION OF ORAL CONTROLLED RELEASE OF MUCOADHESIVE ALGINATE MICROBEADS CONTAINING FLUVASTATIN SODIUM
Authors: VENKATA RAMANA REDDY K  , NAGABHUSHANAM MV  
Published: December 2019

Objective: The aim of this study is to prepare oral controlled release (CR) of mucoadhesive alginate microbeads encapsulating fluvastatin by gastroretention technology.
Methods: The mucoadhesive microbeads containing fluvastatin were produced using emulsification internal gelation technique. The effect of different variables such as sodium alginate concentration and its combination with other hydrophilic polymers, and the effect of various curing agents on particle size, entrapment efficiency, and in vitro studies were evaluated.
Results: There was no marked change in drug entrapment efficiency, and dissolution studies occur during the stability studies of fluvastatin. The in vitro results give data that improvement in the CR of the drug from microbeads compared with marketed tablet. Hence, in this regard, to minimize the frequency of drug administration to reduce side effects. The optimum condition for the preparation of stable alginate beads and produce CR manner was occurred at a higher concentration of combined polymer mixture in equal ratios, i.e., 3% w/v. Infrared spectroscopic study (Fourier transform infrared) confirmed the no incompatibility between drug and other excipients. X-ray diffraction study and differential scanning calorimetry were provided evidence that successful entrapment of drug into the alginates microbeads and drug converted into amorphous nature. The efficiency of mucoadhesion strength of microbeads was determined by wash-off study.
Conclusion: The kinetic modeling of the release data indicates drug release from the microbeads follow anomalous transport mechanism and super Case-II transport mechanism. Drug release is a function of pH dependent and controlled drug release depends on type and concentration of polymer blend and curing agents. The release kinetics of drug from the alginate beads followed zero order.
THE ADVERSARY EFFECT OF OBESITY ON ACADEMIC ACHIEVEMENT AMONG ADOLESCENTS
Authors: WALID ABU RAYYAN  , IBRAHIM S AL-MAJALI  , YAZAN BATARSEH  , SHADI SALEM  , WAEL ABU DAYYIH  
Published: December 2019

Objectives: This study aims to sough implications of the independent and combined demographic variables of weight status, age, food habits, and physical activity on academic achievement in adolescents.
Methods: The study sample consisted of 940 male students in the second secondary class; four secondary schools from Hail city in the Kingdom of Saudi Arabia participated in this study during April 2017. Weight status was assessed through body mass index (BMI) (kg/m2). Participants filled the questioner to evaluate food habits and physical activity on academic achievement.
Results: The mean weight was 74.21±17.36 kg interquartile range (IQR) (45–125), while the mean height was 171.27±7.37 cm IQR (140–193). The mean BMI was 33.73 (IQR 22.0–39.8). The overall prevalence of childhood obesity was 49.6% while the prevalence of overweight was 9.04%. The mean academic score for the second secondary class was 70±9.99 IQR (44–99). BMI has endorsed negatively on academic achievement (r=−0.322, p<0.05).
Conclusion: We can summarize the independent variables as obesity ameliorates academic achievement in a counteractive way; high BMI affects total academic score in a negative pattern, whereas practicing mental games influenced positively the academic achievement and performance.
FORMULATION AND EVALUATION OF OINTMENT CONTAINING SUNFLOWER WAX
Authors: AVISH D MARU  , SWAROOP R LAHOTI  
Published: December 2019

Objective: The objective of the present work was to formulate and evaluate ointment using sunflower wax.
Methods: In the present work, ointment formulations were prepared using sunflower wax by fusion technique. Sunflower wax base was compared with standard base for its pH, appearance, strength, spreadability, water number, and washability. Further, the optimized formulation was prepared with 2% salicylic acid and evaluated for its physicochemical parameters, compatibility study, drug content, in vitro drug diffusion, ex vivo permeability, and skin irritation test using rat skin.
Results: All of the prepared formulations of ointments were evaluated for its physicochemical parameters and all the findings obtained were within the prescribed limit. As compared to the ointment prepared by prototype formulae as per USP and IP, the formulation F3 containing 97% white petrolatum and 3% of sunflower wax showed good viscosity, strength, and spreadability. Based on viscosity, strength, and spreadability, formulation F3 was chosen as an optimized formulation.
Conclusion: The ointment consisting of white petroleum base 97% and 3% sunflower wax can be used for topical and systemic delivery of active ingredient salicylic acid. The results showed that sunflower wax can be used in ointment base as far as its pharmaceutical properties are concerned. It can effectively replace comparatively costlier available ointment bases.