bluuebunny/crossref_metadata_2025_split huggingface dataset:
Capital structure decisions in a period of economic intervention
Authors: Neves Maria Elisabete , Serrasqueiro Zélia , Dias António , Hermano Cristina 
Published: March 2020

PurposeThis paper aims to analyse the Portuguese companies’ determinants of capital structure. To reach this objective, the authors used data from 37 non-financial Portuguese large enterprises and from 4,233 non-financial small and medium enterprises for the period 2010-2016. Additionally, the authors selected a sub-period from 2010 to 2014 for a deeper understanding of the impact of the sovereign debt crisis and the Economic Adjustment Programme of Troika on the capital structure of those companies.Design/methodology/approachThree dependent variables were tested according to debt maturity, and a dynamic panel data model, namely, the generalised method of moments system estimator, was used to test the formulated research hypotheses following Arellano and Bover (1995) and Blundell and Bond (1998) to capture the dynamic nature of the firm’s capital structure decisions.FindingsIn general, the results point out that the capital structure decisions depend on a set of firm-specific factors, and that the effects of the determinants of the debt maturity ratios differ according to the type of firm, i.e. large/small firms, and the economic cycle.Originality/valueTo the best of the authors’ knowledge, this is the first study that has been carried out in Portugal by using two samples of large and small companies for analysing the effects of the Economic Adjustment Programme of Troika on the capital structure of companies. The authors seek to understand which type of companies suffered more because of the effects of the Economic Adjustment Programme of Troika during this period, and which are the capital structure determinants that present greater change. Contrary to what might be expected, large companies are the firms that suffer most from the Economic Adjustment Programme. Probably, because these companies are the most immediate, most scrutinised and those that must show abroad that the bank did not fund them in the long term, because of the imposition and limits to grant credit faced by the banks themselves.
Content marketing capability building: a conceptual framework
Authors: Ho John , Pang Christopher , Choy Crisann 
Published: March 2020

Purpose
The purpose of this study is to develop a conceptual framework that identifies engaging CM practices, specifically how compelling content is created. Content marketing (CM) is fast becoming a key pillar in a company's marketing mix. It is also a requisite for companies seeking to modernise their marketing practices through digitalisation to enhance online branding. However, overlapping definitions and interchangeable terms arising from different perspectives and methodological practices confound what exactly constitutes CM. Although CM is generally accepted as sharing brand content via owned media to gain earned media, a strategic approach, based on evidence-driven research, is needed to navigate through the overwhelming confusion so that companies can better plan and implement CM.

Design/methodology/approach
This paper addresses the scarcity of work with regard to CM practices in Asia. To address this research gap, the study examines content creation practices of five successful companies, based in Singapore, through case studies, interviews and content analyses, to propose a CM capability development framework.

Findings
The findings point to the need for content creation to align with brand values and value creation to create and socialise compelling content for positive impact. Content created for audiences and marketed by brands can generate value when it is consumed and shared. The paper also provided much needed clarity in terms of how CM capability can be gained to minimise costly trial and error.

Research limitations/implications
The study is limited to companies operating in Asia. The framework will require implementation in other regions. Another limitation of the study was that it did not extend to how consumers responded to CM posts. This is an area for further research that can help validate the proposed framework.

Practical implications
The analytical framework adopted in this study can also be used as a functional CM model for marketing managers to construct better CM strategies and informed standards of practice by growing capabilities.

Social implications
CM is also a requisite for companies seeking to modernise their marketing practices through digitalisation to enhance online branding, particularly for small- and medium-sized companies.

Originality/value
This paper addresses the scarcity of work with regard to CM practices in Asia.
Species detection and delineation in the marine planktonic diatoms Chaetoceros and Bacteriastrum through metabarcoding: making biological sense of haplotype diversity
Authors: Gaonkar Chetan C. , Piredda Roberta , Sarno Diana , Zingone Adriana , Montresor Marina , Kooistra Wiebe H. C. F. 
Published: March 2020

SummaryHigh‐throughput sequencing (HTS) metabarcoding is commonly applied to assess phytoplankton diversity. Usually, haplotypes are grouped into operational taxonomic units (OTUs) through clustering, whereby the resulting number of OTUs depends on chosen similarity thresholds. We applied, instead, a phylogenetic approach to infer taxa among 18S rDNA V4‐metabarcode haplotypes gathered from 48 time‐series samples using the marine planktonic diatoms Chaetoceros and Bacteriastrum as test case. The 73 recovered taxa comprised both solitary haplotypes and polytomies, the latter composed each of a highly abundant, dominant haplotype and one to several minor, peripheral haplotypes. The solitary and dominant haplotypes usually matched reference sequences, enabling species assignation of taxa. We hypothesise that the super‐abundance of reads in dominant haplotypes results from the homogenization effect of concerted evolution. Reads of populous peripheral haplotypes and dominant haplotypes show comparable distribution patterns over the sample dates, suggesting that they are part of the same population. Many taxa revealed marked seasonality, with closely related ones generally showing distinct periodicity, whereas others occur year‐round. Phylogenies inferred from metabarcode haplotypes enable delineation of biologically meaningful taxa, whereas OTUs resulting from clustering algorithms often deviate markedly from such taxa.
Changes in texture, composition and sensory characteristics of Camembert cheese made from a mixture of goat milk and cow milk during ripening
Authors: Gebreyowhans Solomon , Zhang Shuwen , Pang Xiaoyang , Yang Baoyu , Wang Tong , Wu Zheng , Lu Jing , Lv Jiaping 
Published: March 2020

The study was conducted to evaluate the nutritional, textural and sensory characteristics of Camembert cheese made from goat milk, cow milk and their blends. The type of milk used affected yield, physicochemical properties and fatty acid profile of the cheeses. The percentages of C6:0, C8:0 and C10:0 acids were higher in the cheeses containing ≥ 75% goat milk. The sensory evaluation results showed differences in texture, colour, aroma and flavour among the cheeses. Cheeses made with the mixture of cow and goat milk particularly 50% goat milk mixed with 50% cow milk (50G:50C) maintained particular positive nutritional characteristics especially with respect to the mineral contents, fatty acids and consumer acceptability.
Inhibition of histone acetyltransferase GCN5 extends lifespan in both yeast and human cell lines
Authors: Huang Boyue , Zhong Dandan , Zhu Jie , An Yongpan , Gao Miaomiao , Zhu Shuai , Dang Weiwei , Wang Xin , Yang Baoxue , Xie Zhengwei 
Published: March 2020

AbstractHistone acetyltransferases (HATs) are important enzymes that transfer acetyl groups onto histones and thereby regulate both gene expression and chromosomal structures. Previous work has shown that the activation of sirtuins, which are histone deacetylases, can extend lifespan. This suggests that inhibiting HATs may have a similar beneficial effect. In the present study, we utilized a range of HAT inhibitors or heterozygous Gcn5 and Ngg1 mutants to demonstrate marked yeast life extension. In human cell lines, HAT inhibitors and selective RNAi‐mediated Gcn5 or Ngg1 knockdown reduced the levels of aging markers and promoted proliferation in senescent cells. Furthermore, this observed lifespan extension was associated with the acetylation of histone H3 rather than that of H4. Specifically, it was dependent upon H3K9Ac and H3K18Ac modifications. We also found that the ability of caloric restriction to prolong lifespan is Gcn5‐, Ngg1‐, H3K9‐, and H3K18‐dependent. Transcriptome analysis revealed that these changes were similar to those associated with heat shock and were inversely correlated with the gene expression profiles of aged yeast and aged worms. Through a bioinformatic analysis, we also found that HAT inhibition activated subtelomeric genes in human cell lines. Together, our results suggest that inhibiting the HAT Gcn5 may be an effective means of increasing longevity.
Plasma proteomic signature of the risk of developing mobility disability: A 9‐year follow‐up
Authors: Osawa Yusuke , Semba Richard D. , Fantoni Giovanna , Candia Julián , Biancotto Angélique , Tanaka Toshiko , Bandinelli Stefania , Ferrucci Luigi 
Published: March 2020

AbstractIntroductionMobility disability is a powerful indicator of poor health in older adults. The biological and pathophysiological mechanism underlying the development of mobility disability remains unknown. This study conducted a data‐driven discovery phase investigation to identify plasma proteins that predict the incidence of mobility disability in community‐dwelling older adults without mobility disability at baseline.MethodsWe investigated 660 women and men, aged 71.9 ± 6.0 (60–94) years, who participated in the Invecchiare in Chianti, “Aging in the Chianti Area” study and completed the 400‐m walk at fast pace (400‐m walk) at enrollment. Median follow‐up time was 8.57 [interquartile, 3.20–9.08] years. SOMAscan technology was used to measure 1,301 plasma proteins at enrollment. The incident of mobility disability was defined as inability to complete the 400‐m walk. Protein‐specific Cox proportional hazard model was adjusted for sex, age, and other important covariates.ResultsPlasma levels of 75 proteins predicted mobility disability (p < .05). Significant proteins were enriched for the KEGG “PI3K‐Akt signaling,” “phagosomes,” and “cytokine–cytokine receptor interaction” pathways. After multiple comparison adjustment, plasma cathepsin S (CTSS; hazard ratio [HR] 1.33, 95% CI: 1.17, 1.51, q = 0.007), growth/differentiation factor 15 (GDF15; HR: 1.45, 95% CI: 1.23, 1.72, q = 0.007), and thrombospondin‐2 (THBS2; HR: 1.44, 95% CI: 1.22, 1.69, q = 0.007) remained significantly associated with high risk of losing mobility.ConclusionCTSS, GDF15, and THBS2 are novel blood biomarkers associated with new mobility disability in community‐dwelling individuals. Overall, our analysis suggests that cellular senescence and inflammation should be targeted for prevention of mobility disability.
Antenatal models of care for women with gestational diabetes mellitus: Vignettes from an international meeting
Authors: Sina Maryam , Cade Thomas J. , Flack Jeff , Nolan Christopher J. , Rajagopal Rohit , Wong Vincent , Burcher Linda , Barry Alison , Gianatti Emily , McCarthy Ana , McNamara Catharine , Mickelson Marina , Hughes Ruth , Jones Tara , Latino Cathy , McIntyre David , Price Sarah , Simmons David 
Published: March 2020

BackgroundGestational diabetes (GDM) is one of the commonest pregnancy complications and is placing an increasing burden on diabetes and obstetric resources.AimsTo describe different antenatal models of care that have developed to address the increasing proportion of pregnancies complicated by GDM.Materials and MethodsNarrative review with thematic analysis from 15 volunteer antenatal diabetes in pregnancy services from Australia and New Zealand identified through a national diabetes organisation. Main outcomes were approaches to patient education, medical nutrition therapy (MNT), ongoing management and escalation of therapy for women with GDM.ResultsAll clinics provided at least one group education and one MNT session within 1–2 weeks of GDM diagnosis. Women from culturally and linguistically diverse communities usually required 1:1 education. Ongoing management of women with GDM was through either all women being seen in the GDM clinic, a step‐up approach (ongoing management by the primary antenatal team with diabetes team referral if self‐blood glucose monitoring (SBGM) or insulin therapy dosage criteria are reached) or step‐down approach (ongoing management by the diabetes team with step‐down to the primary antenatal team if SBGM criteria are reached). Telehealth was used to reduce the burden of clinic attendance, particularly in rural areas.ConclusionsIncreasing numbers, earlier diagnoses, the need to provide care to women in rural, remote areas, and cultural/language differences, have generated a range of different antenatal models of care, allowed better workload accommodation and probably reduced costs. Randomised controlled trials of different models of care, with associated health economic analyses, are urgently needed.
Novel prognostic score for outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal cancer with metachronous peritoneal carcinomatosis
Authors: Chin Ken Min , Tan Grace Hwei Ching , Chia Claramae Shulyn , Ong Johnny Chin Ann , Teo Melissa Ching Ching 
Published: March 2020

AbstractBackgroundThis study aimed to determine pre‐ and peri‐operative parameters with significant predictive value for post‐operative outcomes in patients with recurrent colorectal cancer presenting as peritoneal carcinomatosis undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS‐HIPEC), and to develop a novel prognostic scoring system for prediction of survival outcomes.MethodsA single‐institution review of prospectively collected data from all patients who underwent CRS‐HIPEC between October 2005 and October 2017 was conducted. Univariate and multivariate analyses were used to identify significant parameters for prediction of post‐CRS‐HIPEC disease‐free survival and overall survival (OS).ResultsA total of 278 patients underwent CRS‐HIPEC, of whom 72 were for peritoneal carcinomatosis from recurrent colorectal cancer. Disease‐free interval (DFI; P = 0.006), peritoneal cancer index (PCI; P = 0.001) and left upper quadrant disease (P = 0.023) were significant independent predictors of 3‐year OS. DFI (0.007), PCI (P < 0.001) and intraoperative blood loss (BL; P = 0.001) were significant independent predictors of 5‐year OS. PCI and BL were significant independent predictors of both 3‐year (P = 0.026, PCI; P = 0.009, BL) and 5‐year (P = 0.002, PCI; P = 0.011, BL) disease‐free survival. Predictive models were developed for risk stratification of OS.ConclusionPCI, DFI, left upper quadrant disease and BL have significant predictive value for post‐CRS‐HIPEC outcomes. Risk stratification models allow for more prudent patient selection and ultimately more accurate prognostication of post‐operative outcomes.
Complex care pathways for children with multiple referrals demonstrated in a retrospective population‐based study
Authors: Heggestad Torhild , Greve Gottfried , Skilbrei Birger , Elgen Irene 
Published: March 2020

AbstractAimTo identify children with complex medical needs by examining their patterns of hospital care.MethodsWe conducted a retrospective population‐based study on 18 577 patients aged 6‐12 years from the Haukeland University Hospital register over a 3‐year period (from 2013 to 2015). Data were structured to examine the temporal patterns and sequences of referrals, care episodes and diagnoses, including flow across medical specialties.ResultsOver a third of patients had repeated referrals, and 14.9% of all had three or more. Furthermore, 9.3% of patients were referred to both somatic and mental healthcare services. Patients with such combined referrals had a higher number of referrals as well as a higher number of different diagnoses. Overall, there was a high frequency of non‐specific diagnoses, and 34.8% of patients still had a non‐specific main diagnosis at the end of their hospital contact.ConclusionThis study demonstrates an increased risk for complex care pathways in children with multiple referrals. Interdisciplinary patterns of referrals were relatively common, particularly for patients in mental health care. These findings highlight the importance of developing interdisciplinary‐based approaches for patients with complex complaints.
Antecedents of sustainable supply chain initiatives: Empirical evidence from the S&P 500
Authors: Sebastianelli Rose , Tamimi Nabil 
Published: March 2020

AbstractPrior research on sustainable supply chain management (SSCM) has almost exclusively focused on environmental aspects (GSCM—green supply chain management) and the study of its external drivers and consequences. Framing our study within the “strategy‐conduct‐performance” paradigm, we consider the focal firm's role in the implementation of sustainable supply chain initiatives, social as well as environmental. We use data on the S&P 500 Index retrieved from Bloomberg, including variables for two relevant focal firm strategies: (a) reducing the environmental footprint of the supply chain and (b) reducing social risks in the supply chain (SRSS). Hierarchical logit modeling is carried out to examine the sequential impact of governance board characteristics and the focal firm's adoption of related internal policies and practices on the likelihood of implementing these initiatives along the supply chain. Controlling for industry, firm size, and resources, we find that board structure and diversity influence the implementation of sustainable supply chain initiatives by increasing organizational commitment to environmentally friendly and socially responsible policies and practices. Consequently, empirical evidence exists for the importance of strategic factors, namely a proactive corporate stance on sustainability associated with governance board characteristics, as antecedents of sustainable (environmental and social) supply chain initiatives.
Long‐term efficacy and predictive correlates of response to nivolumab in Japanese patients with esophageal cancer
Authors: Kato Ken , Doki Yuichiro , Ura Takashi , Hamamoto Yasuo , Kojima Takashi , Tsushima Takahiro , Hironaka Shuichi , Hara Hiroki , Kudo Toshihiro , Iwasa Satoru , Muro Kei , Yasui Hirofumi , Minashi Keiko , Yamaguchi Kensei , Ohtsu Atsushi , Kitagawa Yuko 
Published: March 2020

AbstractThe long‐term efficacy of nivolumab in esophageal squamous cell carcinoma and its association with disease biomarkers are currently not well known. Therefore, we investigated the association in Japanese patients with treatment‐refractory advanced esophageal cancer who participated in an open‐label, single‐arm, multicenter phase II study. Patients received nivolumab 3 mg/kg i.v. every 2 weeks until disease progression or unacceptable toxicity, and were followed up for 2 years after the initial dosing of the last patient. Archival tissue samples were collected before treatment and analyzed for programmed death ligand‐1 (PD‐L1) and CD8+ status of tumors and tumor‐infiltrating lymphocytes (TILs) and human leukocyte antigen class 1. Efficacy end‐points included objective response rate (ORR), overall survival (OS), progression‐free survival (PFS), time to response, and duration of response. Of 65 enrolled patients (83% male), 64 were evaluable for efficacy and 41 (63%) for biomarkers. The ORR, median OS, and survival rate were 17.2%, 10.78 months, and 17.2%, respectively. Time to response was 1.45 months and duration of response was 11.17 months. The PD‐L1 positivity of tumor cells was possibly associated with better PFS (2.04 vs 1.41 months, cut‐off 1%) and OS (11.33 vs 6.24 months, cut‐off 1%). Median OS was prolonged in patients with a median number of TILs greater than 63.75% vs 63.75% or less (11.33 vs 7.85 months). Nivolumab showed continued long‐term efficacy, as seen by the stability of PFS and OS, in Japanese patients with esophageal squamous cell carcinoma. Further investigation of PD‐L1 tumor expression and TILs as potential biomarkers for predicting patients likely to benefit from nivolumab therapy is warranted.
Airway hyperresponsiveness, remodeling and inflammation in infants with wheeze
Authors: Malmström Kristiina , Lohi Jouko , Malmberg Leo Pekka , Kotaniemi‐Syrjänen Anne , Lindahl Harry , Sarna Seppo , Pelkonen Anna S. , Mäkelä Mika J. 
Published: March 2020

AbstractBackgroundThe relationship of airway hyperresponsiveness to airway remodeling and inflammation in infants with wheeze is unclear.ObjectiveTo investigate airway hyperresponsiveness, remodeling and inflammation in infants with wheeze and troublesome breathing.MethodsInclusion criteria were as follows: full‐term, 3‐23 months of age; doctor ‐diagnosed wheeze and persistent recurrent troublesome breathing; without obvious structural defect, suspicion of ciliary dyskinesia, cystic fibrosis, immune deficiency or specified use of corticosteroids. Airway hyperresponsiveness (AHR) was evaluated by performing a methacholine bronchial challenge test combined with whole body plethysmography and rapid thoracoabdominal compression. Endobronchial biopsies were analysed for remodeling (thickness of reticular basement membrane and amount of airway smooth muscle) and for inflammation (numbers of inflammatory cells). Correlation analyses were performed.ResultsForty‐nine infants fulfilled the inclusion criteria for the present study. Median age was 1.06 years (IQR 0.6; 1.5). Lung function was impaired in 39/49 (80%) children, at the median age of 1.1 years. Methacholine challenge was successfully performed in 38/49 children. Impaired baseline lung function was correlated with AHR (P = .047, Spearman). In children with the most sensitive quartile of AHR, the percentage of median bronchial airway smooth muscle % and the number of bronchial mast cells in airway smooth muscle were not significantly higher compared to others (P = .057 and 0.056, respectively). No association was found between AHR and thickness of reticular basement membrane or inflammatory cells. Only a small group of children with both atopy and AHR (the most reactive quartile) had thicker airway smooth muscle area than non‐atopics with AHR (P = .031).Conclusions and Clinical RelevanceThese findings do not support the concept that AHR in very young children with wheeze is determined by eosinophilic inflammation or clear‐cut remodeling although it is associated with impaired baseline lung function. The possible association of increased airway smooth muscle area among atopic children with AHR remains to be confirmed.