bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tissue Mechanics and Expression of TROP2 in Oral Squamous Cell Carcinoma with Varying Differentiation
Authors: Zhang Baoping , Gao Shuting , Li Yiting , Li Ruiping , Cao Rui , Cheng Jingyang , Guo Yumeng , Wang Errui , Huang Ying , Zhang Kailiang 
Published: April 2020

Abstract
Background Trophoblast cell surface antigen 2 (TROP2) is overexpressed in many squamous cell carcinomas and contributes to tumor development and invasion. The correlation between the expression of TROP2 and occurrence and development of oral squamous cell carcinoma (OSCC) remains to be understood.Methods We have investigated the role of the specific marker TROP2 in OSCC patients using a combination of biophysics approaches. Analyzed 108 OSCC patient specimens with varying degrees of differentiation using hematoxylin and eosin staining and immunohistochemistry for TROP2 expression, along with Kaplan-Meier survival curve analysis and atomic force microscopy, to understand the morphology and mechanical properties of OSCC tissues.Results In total, 34% poor differentiation underwent high TROP expression. TROP2 as risk factor about patient age (OR = 0.437, P = 0.039), tumor size (OR = 13.148, P = 0.000), TNM stage (OR = 0.141, P = 0.000) during low survival rate. Average surface roughness of low, medium, and highly differentiated OSCC tissues were 448.9 ± 54.8, 792.7 ± 83.6, and 993.0 ± 104.3 nm, respectively. The Pearson coefficient revealed a negative correlation between stiffness and TROP2 expression (r=-0.84, P < 0.01).Conclusion TROP2 expression increased with the decrease in survival rate and negatively correlated with the various degrees of differentiation and tissue mechanics. Taken together, our findings demonstrate that TROP2 may be an indicator of OSCC differentiation that leads to the altered mechanical properties (e.g., stiffness) of OSCC tissues.
Phase II study of sequential S-1 and cyclophosphamide therapy in patients with metastatic breast cancer
Authors: Yanai Keiko , Fujii Takaaki , Horiguchi Jun , Nakazawa Yuko , Kurozumi Sasagu , Obayashi Sayaka , Yajima Reina , Shirabe Ken 
Published: April 2020

Abstract
Purpose: S-1 and cyclophosphamide (CPA) can be given orally, and their combination may have great potential for treating metastatic breast cancer (MBC). A phase I study of sequential S-1 and CPA therapy was conducted in patients with MBC; the recommended doses that were determined for this regimen were 80 mg/m 2 /day for S-1 and 100 mg/m 2 /day for CPA. We then conducted a phase II study of this oral S-1 and CPA regimen. Patients and Methods: This was a single-arm, open-label, single-center prospective phase II study to evaluate the efficacy of a sequential S-1 and CPA regimen for MBC. S-1 was administered orally 2´/day for 14 consecutive days, and then CPA was administered orally 1´/day for 14 consecutive days in a repeating 4-week cycle (S-1 for 2 weeks, CPA for 2 weeks). The primary endpoint was the overall response rate (ORR). Secondary endpoints included the overall survival (OS), progression-free survival (PFS), clinical benefit rate (CBR) and safety. Results: Thirty-six patients were enrolled in this study. The overall response was complete response in 0 (0%), partial response in 12 (33.3%), stable disease in 12 (33.3%), and progressive disease in 11 (30.1%) patients. The ORR was 33.3% (12/36). The CBR was 66.7% (24/36). The mean PFS was 9.5 months (95%CI: 7.1–11.9 months). The OS was 20.2 months (95%CI: 15.0–25.6 months) Grade 3/4 adverse events included neutropenia in seven patients (19.4%). Dose reductions because of adverse events occurred in 12 patients (33.3%). There was no treatment-related mortality. Conclusion: The combination of sequential therapy with S-1 and CPA was tolerable and had efficacy with good disease control. Sequential therapy with S-1 and CPA is a feasible new treatment option for patients with MBC.
Clinical features of gingivostomatitis due to primary infection of Herpes simplex virus in children
Authors: Huang Chen-Wei , Hsieh Chi-Hsien , Lin Ming-Ru , Huang Yhu-Chering 
Published: April 2020

Abstract
Background:
Primary herpetic gingivostomatitis (PHGS) in children, though usually self-limited, might mimic bacterial and enteroviral pharyngitis clinically. We conducted a study to define the clinical features of PHGS in children.
Methods:
Between January 2012 to December 2016, 282 inpatients aged less than 19 years with culture-confirmed herpes simplex virus (HSV) infection in a medical center were identified. Clinical data were retrospectively collected.
Results:
Among the 282 inpatients, 185 cases were considered as PHGS and included for analysis. 99.5% had fever. The mean duration of fever was 5.11 days (± 2.24) with the longest being 17 days. The common oral manifestations included oral ulcers (84.3%), which equally resided in the anterior and posterior part of the oral cavity (65.4% vs. 63.2%), gum swelling and/or bleeding (67.6%), and exudate coated tonsils (16.8%). Leukocytosis (WBC count > 15,000/uL3) was noted in 52 patients (28.1%) and a serum C-reactive protein level > 40 mg/L in 55 patients (29.7%). 65 patients (35%) were diagnosed as PHGS on admission and were significantly more likely to have ulcers over the anterior oral cavity (76.1% vs. 26.7%) and gum swelling/bleeding (76.2% vs. 7.5%, p all < 0.001) on admission and were significantly less likely to receive antibiotic treatment (16.9 vs. 36.7%, p < 0.01) than others. 46 patients (25%) undiagnosed as PHGS on discharge were significantly more likely to have exudate coated on tonsils, receive antibiotic treatment and significantly less likely to have gum swelling/bleeding and oral ulcers (all p values < 0.01).
Conclusion:
Meticulously identifying specific oral manifestations of gum swelling/bleeding and/or ulcers over the anterior oral cavity in children can differentiate PHGS from both bacterial and enteroviral pharyngitis and subsequently reduce unnecessary prescription of antibiotics and medical cost.
Recognition of pathological voices by Human Factor Cepstral Coefficients (HFCC)
Authors: Hamdi Rabeh , HAJJI Salah , Cherif Adnene 
Published: April 2020

Abstract
Several tools have been introduced to achieve early detection of voice disorders. Among these tools are the human factor cepstral coefficients HFCC combined with prosodic parameters, the noise-harmonic ratio (NHR), the harmonic-noise ratio (HNR), analysis of trend fluctuations (DFA) and fundamental frequency (F0). These parameters are introduced and calculated in every frame. In this work, we used a variation of HFCC called equivalent rectangular bandwidth (ERB) to study the effects of HFCC on the classification of pathological voices. Using the HTK classifiers, the classification is carried out on two pathological databases, Massachusetts Eye and Ear Infirmary (MEEI) and Saarbruecken Voice Database (SVD). To assess the performance of the system, we used sensitivity and specificity.
Pushing occupational rehabilitation – Implementation of a therapy diary in the outpatient aftercare of psychosomatic rehabilitation may promote the occupational reintegration process: A survey of therapists and patients.
Authors: Thiel Carolin , Richter Cynthia , Samos Franziska-Antonia Zora , Heise Marcus , Frese Thomas , Fankhänel Thomas 
Published: April 2020

Abstract
Background Treatment results achieved after completion of inpatient psychosomatic rehabilitation are often not permanent. Further participation in an outpatient rehabilitation aftercare may reduce the risk of recurrent disorders and support a successful return to working life. A therapy diary, should accompany the aftercare and bring about the self-reflection process of psychosomatic rehabilitants, could reduce recurrent disease progressions and support the recovery process as a whole. The study focuses on the assessment of the effectiveness and implementation possibilities of a therapy diary in outpatient rehabilitation aftercare. Methods Seven group leaders in Central Germany and eleven psychiatric rehabilitants were interviewed in a qualitative study using partially standardized, guideline-based expert interviews. The data evaluation is based on the Qualitative Content Analysis according to Mayring. Results The results indicate that the accompanying use of a therapy diary within the outpatient rehabilitation aftercare, the rehabilitated by writing down thoughts, emotions, dysfunctional behaviours in problematic situations and thereby experienced successes, allows an intense engagement with their own thoughts and feelings. Through this initiated self-reflection process, the rehabilitant gains a better understanding of one's own behaviour in dealing with oneself and the environment and thereby learns to generate new ways of acting if necessary. Conclusions The use of the therapy diary on a voluntary basis in the outpatient rehabilitation aftercare could support the therapy process and thus the recovery of the rehabilitants and also increase the chance of a successful occupational rehabilitation.
SIX1/EYA1 are novel liver damage biomarkers in chronic hepatitis B and other liver diseases
Authors: Xu Baoyan , Zhang Zhiqiao , Zheng Chong , Tang Yingzi , Tan Zhaoxia , Fu Haiyan , Peng Jing , Xiang Xiaomei , Gan Linlin , Deng Guohong , Mao Qing , Xu Pin-Xian , Ding Jianqiang 
Published: April 2020

Abstract
Background: The aim of this study was to investigate the clinicopathological significance of SIX1/ EYA1 in chronic hepatitis B (CHB) and other liver diseases. Materials and methods: Both SIX1 and EYA1 levels were detected in human serum and liver tissues by enzyme linked immunosorbent assay (ELISA) and immunofluorescent staining, respectively. Results: Serum SIX1 and EYA1 levels were 7.24±0.11 ng/ml and 25.21±0.51 ng/ml, respectively, in 313 CHB patients, and these values were significantly higher than those in 33 healthy controls (2.84±0.15ng/ml and 13.11±1.01ng/ml, respectively; P < 0.05). Serum SIX1 and EYA1 were also significantly increased in patients with many other liver diseases including liver fibrosis, hepatocellular carcinoma, fatty liver disease, alcoholic liver disease, fulminant hepatic failure, autoimmune liver disease, and hepatitis C relative to healthy controls ( P < 0.05). Dynamic observation of these proteins over time in 35 selected CHB patients revealed that SIX1 and EYA1 serum levels increased over an interval. Immunofluorescent staining revealed that both SIX1 and EYA1 were only expressed in hepatic stellate cells (HSCs), and their increased expression was evident in CHB liver tissue. Conclusion: Both SIX1 and EYA1 are novel biomarkers of liver damage in CHB and other liver diseases, with potential clinical utility.
Perioperative circulating tumor cells (CTCs) and CTC-white blood cells detected by a size-based platform predict worse prognosis in renal cell cancer patients
Authors: Wang Zhen-Long , Zhang Peng , Chong Yue , Xue Yu-Quan , Yang Xiao-Jie , Li He-Cheng , Zhang Ya-Ping , Li Zhao-Lun , Xue Li , Li Hong-Liang , Chen Qi , Chong Tie 
Published: April 2020

Abstract
Purpose To explore the clinical significance of perioperative CTCs counts, EMT-CTCs and CTC- white blood cells (WBCs) in renal cancer patients.Materials and Methods A total of 131 patients with renal cancer who underwent operation from the Second Affiliated Hospital of Xi’an Jiaotong University were enrolled. 20 patients with benign renal diseases were used as control. 5 mL Peripheral blood was extracted from 131 patients with renal cancer before operation and about 3 months after operation. Control patients took blood at the corresponding time. CanPatrol CTC detection technique was used to enrich and identify CTCs, EMT-CTCs and CTC-WBCs simultaneously.Results All patients enrolled were T1-3N0M0. 52 renal cancer patients received radical resection, while other 79 patients underwent nephron-sparing surgery. The positive rate of CTC, mesenchymal CTCs (MCTC) and CTC-WBC before surgery were 95.4% (125/131), 61.1% (80/131) and 11.5% (15/131), respectively. Preoperative total CTCs, mesenchymal CTCs or CTC-WBCs were poorly correlated with patients’ parameters. Preoperative CTC, MCTC or CTC-WBC showed little association with progression-free survival (PFS), while post-operation total CTC (≥ 6), positive mesenchymal CTCs and positive CTC-WBC significantly correlated with early recurrence and metastasis, and remained independent indicators for worse PFS. In addition, the elevation of CTC and MCTC after operation were also correlated with unfavourable PFS.Conclusions With the detection of CTCs in peripheral blood, better risk stratification of renal cancer patients might therefore help to identify a subset of patients that might have higher recurrent risk than the overall population of patients.
The efficacy of single-segment anterior decompression, fixation and fusion in the treatment of traumatic spondylolisthesis of the axis
Authors: Zhang Dan , Luo Jing , Zhou Yongchun 
Published: April 2020

Abstract
Background

This study evaluated the clinical efficacy of single-segment anterior decompression, fixation and fusion in patients with traumatic spondylolisthesis of the axis.
Methods

From January 2008 to January 2017, 49 patients with traumatic spondylolisthesis of the axis were treated in our centre using single-segment anterior decompression, fixation and fusion. Clinical and radiographic results were analysed. Clinical efficacy was evaluated according to the operative time and blood loss. The Frankel scale was used to evaluate neurological function. A visual analogue scale was used to assess neck pain. Bone graft fusion, instrumentation failure and cervical curvature were monitored via radiography.
Results

The operative time and intraoperative blood loss of the 49 patients averaged 90.5 ± 4.6 min and 118.5 ± 38.12 ml, respectively. Intervertebral bone grafts were fused in patients with an average fusion time of 6.7 ± 1.0 months (range, 5–8). Cervical curvature was significantly higher at 3 months and 1 year after surgery than before surgery, and the American Spinal Cord Injury Association score at 12 months after surgery was significantly higher than that before surgery.
Conclusion

Single-segment anterior decompression, fixation and fusion can achieve remarkable curative effects in patients with traumatic spondylolisthesis of the axis including satisfactory anatomical reduction, and this strategy promotes the recovery of spinal cord nerve function.
Mapping Evidence on Management of Cervical Cancer in Sub-Saharan Africa: Scoping Review Protocol
Authors: Zibako Petmore , Hlongwa Mbuzeleni , Tsikai Nomsa , Manyame Sarah , Ginindza Themba G 
Published: April 2020

Abstract
BackgroundCancer is a non-communicable disease, and is the number two leading cause of death globally. Among all cancers, cervical cancer is the number one killer of women in Low-Income countries (LICs). Cervical cancer is a well understood preventable cancer. The rates of cervical cancer are very varied and inversely proportional to effectiveness of disease management policies. Management of cervical cancer includes: prevention, screening, diagnosis and treatment. The main objective of this scoping review is to map evidence on cervical cancer management in sub-Saharan Africa (SSA) to understand the coverage of cervical cancer prevention and treatment services and provide an opportunity to generate knowledge on risk factors, attitudes and practices extendable globally.Methods and analysisThis review will be guided by Arksey and O’Malley’s framework recommended for conducting scoping review studies. The Preferred Reporting Items for Systematic Review and Meta-Analysis extension for Scoping Reviews (PRISMA-Scr) checklist will also be completed to ensure that the review adheres to sound methodological rigour acceptable for scoping review studies. The following electronic databases will be search for potentially eligible articles: PubMed, Ebsco Host, Scopus and Cochrane Database of Systematic Reviews. Study screening procedures recommended by Higgins and Deeks will be followed.DiscussionCervical cancer can become a disease of the past with a proper control strategy in place. It is therefore imperative to map available evidence on management of cervical cancer to inform policy and advocacy action. More knowledge on the status quo will guide policy makers in ensuring cancer management guiding policies are formulated/updated/ revised accordingly.Scoping review registration: Not registered with PROSPERO (not needed).Protocol and registration: This scoping review was not registered.
Remark on the Swarm data residual distribution
Authors: Khokhlov Andrey 
Published: April 2020

Abstract
The behavior of data in space and time is usually based on a preliminary model of variability. Deviations observed from the model characterize both the model itself and possible data errors. Gaussian error theory is usually used to characterize the distribution of deviations, but very often non-gaussian nature of these deviations is visually obvious. We may see this on the semi-logarithmic chart of the corresponding histogram. Therefore, the percentage of large deviations may be significantly larger than that predicted with the help of the Gaussian error theory: a different method of processing the residuals is necessary for real data. If we assume that the variability itself depends on space and time (in the language of probability theory this behavior is characterized as a mixture of Gaussian distributions), then the non-gaussian shapes of histograms can be explained. For practical purposes, an explicit characterization of the mixing law is of interest, since the share of significant deviations is determined by this very law. The article substantiates the explicit description of the mixing law and shows how to calculate its parameters from the data using the example of magnetic data. Such an approach is also applicable in more general situations.
Survival Benefit of Post-Operative Radiotherapy in Patients with Resectable Pancreatic Head Adenocarcinoma
Authors: gan yu , song su , bo li , fan cheng 
Published: April 2020

Abstract
Background Controversy still exis ts with regard to the beneficial effects of adjuvant radiotherapy (RT) on patients with resectable pancreatic head adenocarcinoma. The aim was to investigate the role of post-operative RT in resectable pancreatic head adenocarcinoma.Methods A total of 2092 patients with resectable pancreatic head adenocarcinoma were enrolled from 2004 to 2016. The data of these patients were obtained from the Surveillance, Epidemiology and End Results (SEER) database of the National Cancer Institute. The propensity score matching method was used to avoid selection bias of the treatment. A multivariable Cox proportional hazards model was used in analyzing the survival benefit from the utilization of post-operative RT.Results In total, 186 patients received post-operative RT after pancreatic head adenocarcinoma resection. Compared with patients who only underwent surgery (n = 1906), the subjects who had postoperative RT were younger (P = 0.000) and had a greater TNM stage (P = 0.00). The baseline characteristics of the two groups were well matched, and more notable in the clinicopathologic and demographic aspects. Before and after matching, the patients who received post-operative RT after pancreatic head adenocarcinoma resection had a higher survival rate than those who underwent only resection (P = 0.00). Subgroups analyses revealed that this benefit was restricted to patients with Lymph node invasion (P = 0.00).Conclusions Pancreatic head adenocarcinoma resection followed by post-operative RT demonstrated considerable survival benefit in relation to surgery alone.
A nomogram prediction model for lymph node metastasis in endometrial cancer patients
Authors: Wang Zhiling , Zhang Shuo , Ma Yifei , Li Wenhui , Tian Jiguang , Liu Ting 
Published: April 2020

Abstract
Background: The determination of lymph node(LN) status is critical for evaluating prognosis and identifying the necessity of adjuvant therapy of endometrial cancer(EC) patients. However, the significance of systematic lymphadenectomy remains controversial. This study aimed to explore the risk factors for lymph node metastasis(LNM) in patients with EC and develop a clinically useful nomogram based on clinicopathological parameters to predict it.Methods: A total of 1517 consecutive patients who underwent staging surgery for EC were abstracted from Qilu Hospital of Shandong University. Parameters including patient-related, tumor-related, and preoperative hematologic examination-related were analyzed by univariate and multivariate logistic regression to determine the correlation with LNM. Based on the multivariate results, a nomogram was constructed and underwent further validation to predict the probability of LNM.Results: The nomogram was constructed and incorporated valuable parameters from the final multivariate model including histological type, histological grade, depth of myometrial invasion, LVSI, cervical involvement, parametrial involvement, and HGB levels. The nomogram was cross-validated internally by the 200 bootstrap sample and showed good discrimination accuracy with an AUC of 0.899.Conclusions: We developed and validated a 7-variable nomogram with a high concordance probability to predict the risk of LNM in patients with EC.
Household Wealth Inequalities in High Body Mass Index among Women of Childbearing Age: Evidence from the Ghana Demographic and Health Survey
Authors: Dankwah Emmanuel , Koduah-Benewaa Priscilla 
Published: April 2020

Abstract
Background

Ghana is currently experiencing higher body mass index (BMI), that is overweight and obesity, among reproductive-aged women. However, understanding the role of socioeconomic status in the high BMI among this cohort has not been studied extensively in Ghana and the few existing studies in the country have generated mixed results. This study aims to examine household wealth inequalities in high BMI among Ghanaian women of childbearing age.
Methods

The 2014 Ghana Demography and Health Survey (GDHS) dataset was analyzed. A univariable and multivariable regression model with a logit link function was specified to ascertain the effect of household wealth inequalities in high BMI among Ghanaian women. Furthermore, concentration index and curve were used to measure the degree of household wealth inequalities in high BMI among reproductive aged women.
Results

This study found high BMI prevalence of 35.9 percent with significant household wealth-related inequalities (Concentration index = 0.24, 95%CI (confidence interval): 0.22–0.26). The analysis revealed that high BMI is concentrated among wealthier women. Compared to poorest women, poorer (AOR (Adjusted odds ratio) = 2.18, 95%CI: 1.66–2.85), middle-class (AOR = 4.44, 95%CI: 3.24–6.09), richer (AOR = 7.75, 95%CI: 5.53–10.86) and richest (AOR = 11.03, 95%CI: 8.07–15.06) women were more likely to have high BMI. On top of that, socioeconomic characteristics including age, marital status, and education of reproductive-aged women were significantly associated with high BMI.
Conclusions

The research revealed that a woman from a wealthier household had higher likelihood of having high BMI relative to those from a less wealthy household. Also, women who were educated and cohabiting, formerly or currently married had an increased risk of having high BMI. This observation suggests targeted policy interventions and programs that promote healthy body weight to reduce the high BMI prevalence among women of childbearing age in Ghana.