bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triamcinolone acetonide injections for the treatment of recalcitrant post-radical prostatectomy vesicourethral anastomotic stenosis: A retrospective look at efficacy and safety
Authors: Neu Sarah , Vigil Humberto , Locke Jennifer A. , Herschorn Sender 
Published: August 2020

Introduction: We aimed to evaluate the success of bladder neck injections of triamcinolone at the time of transurethral bladder neck incision (BNI) for prevention of recurrent vesicourethral anastomotic stenosis (VUAS) following prostate cancer treatment.
Methods: This is a retrospective cohort study examining patients with recurrent VUAS post-RP ± radiation treated with triamcinolone injections at the time of BNI. VUAS was diagnosed by symptoms followed by cystoscopy or urethrography. The outpatient procedures were done under general anesthesia. Cold knife incisions were made at the three, nine, and 12 o’clock BN positions, followed by triamcinolone injections (4 mg/mL) into the three and nine o’clock incision sites. Treatment outcomes were determined with cystoscopy.
Results: Eighteen men underwent 25 procedures over a four-year period. Median age at diagnosis of VUAS was 65 (interquartile range [IQR] 61–68); median time to VUAS from RP was eight months (IQR 5–12). Fourteen patients (78%) had radiation treatment. The cohort had 128 unsuccessful VUAS treatments, with a median of five failed treatments per patient (IQR 3–10). Failed treatments included BN dilation, BNI, BN injection of mitomycin C, and urethral stent placement. Success rate after a mean of 16.3 months (standard deviation [SD] 8.1) from the time of triamcinolone injection was 83% (15/18). Six patients went on to have successful incontinence surgery. Five patients (28%) had treatment complications (bleeding, urinary tract infection, pain, and urinary extravasation). The three non-responders are stable and awaiting re-treatment with triamcinolone injection.
Conclusions: Triamcinolone bladder neck injections for post-RP VUAS are a useful and safe treatment for recurrent stenosis.
Cranial Strain Patterns Associated With Concussions
Authors: Schwartzberg Lauren , Aslanyan Lilit , Angelo Nicole , Mancini Jayme , Kooyman Patricia S. , Abu-Sbaih Reem , Zwibel Hallie , Yao Sheldon C. 
Published: August 2020

Abstract

Context
Concussions can cause cognitive impairment, somatic symptoms, and behavioral changes. Symptoms may vary in severity, depending on the degree of traumatic force. Due to the biomechanical nature of this trauma, cranial somatic dysfunctions may commonly be seen in patients with concussion.

Objective
To determine whether patients were more likely to have nonphysiologic cranial somatic dysfunctions than physiologic cranial somatic dysfunctions after sustaining a concussion.

Methods
College athletes who had a concussion based on the Immediate Post-Concussion Assessment and Cognitive test were evaluated by a physician within 1 week of the injury. Patients were evaluated for somatic dysfunctions of the cranium. Cranial somatic dysfunctions were documented; test scores and force vectors were compared with the type of strain pattern using SPSS, with P<.05 demonstrating statistical significance.

Results
Sixteen patients were included in the study: 10 with nonphysiologic cranial strain somatic dysfunctions and 6 with physiologic dysfunctions. Compared with lateral forces, forces of impact with anterioposterior vectors were associated 1.5 times more often with nonphysiologic rather than physiologic cranial somatic dysfunctions (P=.697). An analysis of specific cranial strain patterns and impact force vectors showed no statistical significance (P=.096).

Conclusion
There was no statistically significant association showing that concussion patients were more likely to have nonphysiologic cranial somatic dysfunctions compared with physiological cranial somatic dysfunctions. However, nonphysiologic cranial somatic dysfunctions did show a trend toward association with concussion. Further studies are needed to better understand the potential association between concussion and cranial somatic dysfunctions.
Assessing Meteorological Variables, Larvae Free Rate and Dengue Incidence in Yogyakarta, Indonesia
Authors: Zannah Juhrati Raodatul , Sulistyawati Sulistyawati 
Published: August 2020

Aims: Dengue is a disease closely related to the environment, including several climatic variables such as temperature, humidity, and wind speed. This research attempted to illustrate the relationship between dengue fever incidence and climatic factors, larva free rate (LFR) or Angka Bebas Jentik (ABJ) in Yogyakarta city, Indonesia.
Methodology: Secondary data from meteorological agency and district health office were collected and analyzed using Spearman Rank Test and Multiple Linear Regression Test.
Results: Temperature, air humidity and wind speed were associated with dengue incidence in Yogyakarta city during 2016-2018. Correlation between rainfall and dengue was r = 0.27 and p value = 0.11; temperature and dengue r =0.62 and p value = 0.000; humidity and dengue r=0.38 and p value 0.02; wind speed and dengue r=-0.36 and p value = 0.03; r = -0.36. Larvae free rate and dengue r=0.04 and p value = 0.77.
Conclusion: Climate variables are an important factor affecting the incidence of dengue fever. To decrease the incidence, it is necessary to educate the community on improving awareness related to the mosquito breeding place.
Assessment of Gene Action for Grain Micronutrient Content, Yield and Yield Contributing Traits in Rice (Oryza sativa L.)
Authors: Kumar Ashutosh , Kumar Avinash , Singh N. K. , Kumar Rajesh , Nilanjaya . , Singh S. K. , Singh Mithilesh Kumar , Tigga Aman , Banshidhar . 
Published: August 2020

Biofortification of food crops using conventional breeding or biotechnological approach is gaining momentum to alleviate micronutrient malnutrition. Rice is a nice choice for biofortification of grain iron and zinc content as this is a cheap and chief staple food for millions of peoples world-wide particularly the poor. In present study, generation mean analysis was done to estimate the nature and magnitude of gene effects for grain iron and zinc content in rice cross Khusisoi-RI-Sareku × IR 91175-27-1-3-1-3. Scaling test and Joint scaling test indicated the influence of epistasis on the expression of yield, its component traits and grain Fe and Zn content and inadequacy of additive-dominance model to explain the variation in different generations. Dominance [h] gene effect was of higher magnitude as compared to additive [d] gene effect for both grain iron and grain zinc content. Additive × additive, additive × dominance and dominance × dominance component was significant for both grain Fe and Zn content, whereas dominance × dominance component was predominant for both grain Fe and Zn content. Dominance [h] gene effect and dominance × dominance interaction acted in opposite directions, indicating duplicate type of gene action controlling the expression of both grain Fe and grain Zn content which could be a bottleneck to exploit heterosis. Heterosis breeding and recombination breeding with postponement of selection till later generations, could be effective in improving both grain Fe and grain Zn content in rice.
Impaired proteasome activity and neurodegeneration with brain iron accumulation in FBXO7 defect
Authors: Correa‐Vela Marta , Lupo Vincenzo , Montpeyó Marta , Sancho Paula , Marcé‐Grau Anna , Hernández‐Vara Jorge , Darling Alejandra , Jenkins Alison , Fernández‐Rodríguez Sandra , Tello Cristina , Ramírez‐Jiménez Laura , Pérez Belén , Sánchez‐Montáñez Ángel , Macaya Alfons , Sobrido María J. , Martinez‐Vicente Marta , Pérez‐Dueñas Belén , Espinós Carmen 
Published: August 2020

AbstactFBXO7 is implicated in the ubiquitin–proteasome system and parkin‐mediated mitophagy. FBXO7defects cause a levodopa‐responsive parkinsonian‐pyramidal syndrome(PPS). Methods: We investigated the disease molecular bases in a child with PPS and brain iron accumulation. Results: A novel homozygous c.368C>G (p.S123*) FBXO7 mutation was identified in a child with spastic paraplegia, epilepsy, cerebellar degeneration, levodopa nonresponsive parkinsonism, and brain iron deposition. Patient’s fibroblasts assays demonstrated an absence of FBXO7 RNA expression leading to impaired proteasome degradation and accumulation of poly‐ubiquitinated proteins. Conclusion: This novel FBXO7 phenotype associated with impaired proteasome activity overlaps with neurodegeneration with brain iron accumulation disorders.
Monolithic Heterogeneous Integration of 3D Radio Frequency L−C Elements by Self‐Rolled‐Up Membrane Nanotechnology
Authors: Yang Zhendong , Kraman Mark D. , Zheng Zhuoyuan , Zhao Haojie , Zhang Jialiang , Gong Songbin , Shao Yang Victoria , Huang Wen , Wang Pingfeng , Li Xiuling 
Published: August 2020

AbstractThis work reports a three‐dimensional (3D) radio frequency L−C filter network enabled by a CMOS‐compatible two‐dimensional (2D) fabrication approach, which combines inductive (L) and capacitive (C) self‐rolled‐up membrane (S‐RuM) components monolithically into a single L−C network structure, thereby greatly reducing the on‐chip area footprint. The individual L−C elements are fabricated in‐plane using standard semiconductor processing techniques, and subsequently triggered by the built‐in stress to self‐assemble and roll into cylindrical air‐core architectures. By designing the planar structure geometry and constituent layer properties to achieve a specific number of turns with a desired inner diameter when the device is rolled up, the electrical characteristics can be engineered. The network layouts of the L and C components are also reconfigurable by selecting appropriate input, output, and ground contact routing topographies. The devices demonstrated here operate over the range of ≈1−10 GHz. Their area and volume footprints are ≈0.09 mm2 and ≈0.01 mm3, respectively, which are ≈10× smaller than most of the comparable conventional filter designs. These S‐RuM‐enabled 3D microtubular L−C filter networks represent significant advancement for miniaturization and integration of passive electronic components for applications in mobile connectivity and other frequency range.
A Compliant Ionic Adhesive Electrode with Ultralow Bioelectronic Impedance
Authors: Pan Liang , Cai Pingqiang , Mei Le , Cheng Yuan , Zeng Yi , Wang Ming , Wang Ting , Jiang Ying , Ji Baohua , Li Dechang , Chen Xiaodong 
Published: August 2020

AbstractSimultaneous implementation of high signal‐to‐noise ratio (SNR) but low crosstalk is of great importance for weak surface electromyography (sEMG) signals when precisely driving a prosthesis to perform sophisticated activities. However, due to gaps with the curved skin during muscle contraction, many electrodes have poor compliance with skin and suffer from high bioelectrical impedance. This causes serious noise and error in the signals, especially the signals from low‐level muscle contractions. Here, the design of a compliant electrode based on an adhesive hydrogel, alginate–polyacrylamide (Alg‐PAAm) is reported, which eliminates those large gaps through the strong electrostatic interaction and abundant hydrogen bond with the skin. The obtained compliant electrode, having an ultralow bioelectrical impedance of ≈20 kΩ, can monitor even 2.1% maximal voluntary contraction (MVC) of muscle. Furthermore, benefiting from the high SNR of >5:1 at low‐level MVC, the crosstalk from irrelevant muscle is minimized through reducing the electrode size. Finally, a prosthesis is successfully demonstrated to precisely grasp a needle based on a 9 mm2 Alg‐PAAm compliant electrode. The strategy to design such compliant electrodes provides the potential for improving the quality of dynamically weak sEMG signals to precisely control prosthesis in performing purposefully dexterous activity.
Chemical Manipulation of Abscisic Acid Signaling: A New Approach to Abiotic and Biotic Stress Management in Agriculture
Authors: Hewage Kamalani Achala H. , Yang Jing‐Fang , Wang Di , Hao Ge‐Fei , Yang Guang‐Fu , Zhu Jian‐Kang 
Published: August 2020

AbstractThe phytohormone abscisic acid (ABA) is the best‐known stress signaling molecule in plants. ABA protects sessile land plants from biotic and abiotic stresses. The conserved pyrabactin resistance/pyrabactin resistance‐like/regulatory component of ABA receptors (PYR/PYL/RCAR) perceives ABA and triggers a cascade of signaling events. A thorough knowledge of the sequential steps of ABA signaling will be necessary for the development of chemicals that control plant stress responses. The core components of the ABA signaling pathway have been identified with adequate characterization. The information available concerning ABA biosynthesis, transport, perception, and metabolism has enabled detailed functional studies on how the protective ability of ABA in plants might be modified to increase plant resistance to stress. Some of the significant contributions to chemical manipulation include ABA biosynthesis inhibitors, and ABA receptor agonists and antagonists. Chemical manipulation of key control points in ABA signaling is important for abiotic and biotic stress management in agriculture. However, a comprehensive review of the current knowledge of chemical manipulation of ABA signaling is lacking. Here, a thorough analysis of recent reports on small‐molecule modulation of ABA signaling is provided. The challenges and prospects in the chemical manipulation of ABA signaling for the development of ABA‐based agrochemicals are also discussed.
Tree biomass distribution patterns with a forest succession in subtropical China
Authors: Zhang‐Quan Zeng , Hong Tang , Qing Hu , Si‐Long Wang , Minghong Li , Rui Yang , Yandong Niu , Can‐Ming Zhang 
Published: August 2020

AbstractTo better understand the effect of forest succession on biomass sequestration, we investigated biomass stock and allocation of evergreen broadleaf forest, a major zonal forest type in subtropical China. To analyze the biomass patterns and dynamics with forest succession, three forest types, pine (Pinus massoniana Lamb.) forest (PF), pine and broadleaf mixed forest (MF) and evergreen broadleaf forest (BF), were selected and their tree biomasses were investigated. The results showed that the biomass of the arbor layer was the highest in BF, which was 292.51 t/hm2, followed by MF and PF with 206.87 and 171.76 t/hm2, respectively. It indicated that tree biomass increased with the forest succession. The biomass patterns in arbor layer were similar during the forest succession, in which the biomass of trunks accounted for the largest proportion in the total biomass decreased with the forest succession, but the proportion of the biomass of roots increased with the forest succession. The biomass of the diameter class above 20 cm in PF, MF and BF contributed to a large proportion of the total biomass. With the succession, the increase of tree species diversity has a positive effect on the increase of tree biomass. Our results indicated that forest succession can sequestrate biomass carbon and alleviate the global climate change.
A Multifunctional Microfluidic Platform for High‐Throughput Experimentation of Electroorganic Chemistry
Authors: Mo Yiming , Rughoobur Girish , Nambiar Anirudh M. K. , Zhang Kara , Jensen Klavs F. 
Published: August 2020

AbstractElectroorganic synthesis is a promising tool to design sustainable transformations and discover new reactivities. However, the added setup complexity caused by electrodes in the system impedes efficient screening of reaction conditions. Herein, we present a microfluidic platform that enables automated high‐throughput experimentation (HTE) for electroorganic synthesis at a 15‐microliter scale. Two HTE modules are demonstrated: 1) the rapid electrochemical reaction condition screening for a radical–radical cross‐coupling reaction on micro‐fabricated interdigitated electrodes, and 2) measurements of kinetics for mediated anodic oxidations using the microliter‐scale cyclic voltammetry. The presented modular approach could be deployed for a range of other electroorganic chemistry applications beyond the demonstrated functionalities.
Modulating Orientational Order to Organize Polyhedral Nanoparticles into Plastic Crystals and Uniform Metacrystals
Authors: Lee Yih Hong , Shi Wenxiong , Yang Yijie , Kao Ya‐Chuan , Lee Hiang Kwee , Chu Rongrong , Pang Yee Ling , Lay Chee Leng , Li Shuzhou , Ling Xing Yi 
Published: August 2020

AbstractIn nanoparticle self‐assembly, the current lack of strategy to modulate orientational order creates challenges in isolating large‐area plastic crystals. Here, we achieve two orientationally distinct supercrystals using one nanoparticle shape, including plastic crystals and uniform metacrystals. Our approach integrates multi‐faceted Archimedean polyhedra with molecular‐level surface polymeric interactions to tune nanoparticle orientational order during self‐assembly. Experiments and simulations show that coiled surface polymer chains limit interparticle interactions, creating various geometrical configurations among Archimedean polyhedra to form plastic crystals. In contrast, brush‐like polymer chains enable molecular interdigitation between neighboring particles, favoring consistent particle configurations and result in uniform metacrystals. Our strategy enhances supercrystal diversity for polyhedra comprising multiple nondegenerate facets.
Latent Class Growth Analysis of Gout Flare Trajectories: A Three‐Year Prospective Cohort Study in Primary Care
Authors: Watson Lorraine , Belcher John , Nicholls Elaine , Muller Sara , Mallen Christian , Roddy Edward 
Published: August 2020

ObjectiveTo investigate the existence of distinct classes of gout flare trajectories and compare their gout‐specific, comorbid, and sociodemographic characteristics.MethodsIn a prospective cohort study, adults with gout who were registered with 20 general practices self‐reported the number of gout flares experienced at baseline and after 6, 12, 24, and 36 months via postal questionnaires. Latent class growth analysis (LCGA) was used to identify distinct gout flare trajectory classes. Statistical criteria and clinical interpretability were used to decide the optimal number of classes. Baseline comorbidities, medications, and sociodemographic and gout‐specific characteristics of members of each class were described.ResultsA total of 1,164 participants (mean ± SD age 65.6 ± 12.5 years; 972 [84%] male) were included. Six latent gout flare trajectory classes were identified: “frequent and persistent” (n = 95), “gradually worsening” (n = 276), “frequent then improving” (n = 14), “moderately frequent” (n = 287), “moderately frequent then improving” (n = 143), and “infrequent” (n = 349). The “frequent and persistent” trajectory had the most class members classified as obese and, along with the “gradually worsening” class, the highest proportion who were socioeconomically deprived. The “frequent and persistent,” “gradually worsening,” and ”frequent then improving” classes had the highest proportions of class members with an estimated glomerular filtration rate <60 ml/minute/1.73 m2. The “infrequent” gout flare class was associated with more frequent allopurinol use and lower urate levels.ConclusionSix distinct gout flare trajectories were identified. Infrequent flares were associated with allopurinol use and lower serum urate levels, supporting the use of urate‐lowering therapy to reduce flare frequency. The characteristics of flare trajectory classes could help to target interventions and improve patient care.
Structure of Magnesium Chloride Complexes in Ethereal Systems: Computational Comparison of THF and Glymes as Solvents for Magnesium Battery Electrolytes
Authors: Jankowski Piotr , Lastra Juan Maria García , Vegge Tejs 
Published: August 2020

AbstractThe structure of the electrolyte is crucial for the performance of rechargeable magnesium batteries. Doubly charged cations interact much stronger with both anions and solvent molecules, forming different size clusters. Here, we apply DFT calculations to investigate salt solvation by altering the first solvation shell of the magnesium‐chloride complexes in different ethereal solvents: tetrahydrofuran, monoglyme, diglyme, triglyme and tetraglyme. The analysis was performed by looking for the most stable structures, considering mono‐, di‐ and trimeric clusters of MgxCly. The determination of clusters geometries, together with their energies, resulted in a comprehensive picture of the thermodynamically preferred state of the electrolyte, and allowed for a simple assessment of the electrochemical activity of the electrolyte. Our analysis shows that clustering is beneficial for desolvation of magnesium from the cluster, but causes overpotentials due to hindered electron transfer.
Metaorganismusforschung trifft Schule
Authors: Claussen Christina , Knapp Jana Madlen , Kapitza Martina , Bernholt Andrea , Schulenburg Hinrich , Kremer Kerstin 
Published: August 2020

ZusammenfassungBeim Darwin‐Tag an der Universität zu Kiel bieten Wissenschaftler/innen Lernenden der Sekundarstufe II einen Einblick in aktuelle biologische Forschungsgebiete. 2018 vermittelte die ganzheitliche Betrachtung eines Metaorganismus Schüler/innen neue naturwissenschaftliche Denk‐ und Arbeitsweisen, die für ein tiefgreifendes Verständnis biologischer Zusammenhänge wie auch für heutige Krankheitsbilder wichtig sind. Damit neue Erkenntnisse aus der biologischen Forschung an Schüler/innen herangetragen werden, können verschiedene Formate der Wissenschaftskommunikation genutzt werden. Eine Möglichkeit sind Besuche von außerschulischen Lernorten wie des Darwin‐Tags der Universität zu Kiel, der Bezug zu einem aktuellen biologischen Forschungsthema nimmt. Um die Bedeutung von Wissenschaftskommunikation zu verdeutlichen, wurden in diesem Artikel der Darwin‐Tag und eine begleitende Unterrichtseinheit vorgestellt. Darüber hinaus werden Einblicke in die Evaluierung dieses Outreach‐Formates gegeben.
Laparoscopic versus open subtotal gastrectomy for gastric adenocarcinoma: cost-effectiveness analysis
Authors: Gosselin-Tardif A , Abou-Khalil M , Mata J , Guigui A , Cools-Lartigue J , Ferri L , Lee L , Mueller C 
Published: August 2020

Abstract

Background
Laparoscopic subtotal gastrectomy (LSG) for cancer is associated with good perioperative outcomes and superior quality of life compared with the open approach, albeit at higher cost. An economic evaluation was conducted to compare the two approaches.

Methods
A cost–effectiveness analysis between LSG and open subtotal gastrectomy (OSG) for gastric cancer was performed using a decision-tree cohort model with a healthcare system perspective and a 12-month time horizon. Model inputs were informed by a meta-analysis of relevant literature, with costs represented in 2016 Canadian dollars (CAD) and outcomes measured in quality-adjusted life-years (QALYs). A secondary analysis was conducted using inputs extracted solely from European and North American studies. Deterministic (DSA) and probabilistic (PSA) sensitivity analyses were performed.

Results
In the base-case model, costs of LSG were $935 (€565) greater than those of OSG, with an incremental gain of 0·050 QALYs, resulting in an incremental cost–effectiveness ratio of $18 846 (€11 398) per additional QALY gained from LSG. In the DSA, results were most sensitive to changes in postoperative utility, operating theatre and equipment costs, as well as duration of surgery and hospital stay. PSA showed that the likelihood of LSG being cost-effective at willingness-to-pay thresholds of $50 000 (€30 240) per QALY and $100 000 (€60 480) per QALY was 64 and 68 per cent respectively. Secondary analysis using European and North American clinical inputs resulted in LSG being dominant (cheaper and more effective) over OSG, largely due to reduced length of stay after LSG.

Conclusion
In this decision analysis model, LSG was cost-effective compared with OSG for gastric cancer.