bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Southeast Asian origin for present-day non-African human Y chromosomes
Authors: Hallast Pille , Agdzhoyan Anastasia , Balanovsky Oleg , Xue Yali , Tyler-Smith Chris 
Published: July 2020

AbstractThe genomes of present-day humans outside Africa originated almost entirely from a single out-migration ~ 50,000–70,000 years ago, followed by mixture with Neanderthals contributing ~ 2% to all non-Africans. However, the details of this initial migration remain poorly understood because no ancient DNA analyses are available from this key time period, and interpretation of present-day autosomal data is complicated due to subsequent population movements/reshaping. One locus, however, does retain male-specific information from this early period: the Y chromosome, where a detailed calibrated phylogeny has been constructed. Three present-day Y lineages were carried by the initial migration: the rare haplogroup D, the moderately rare C, and the very common FT lineage which now dominates most non-African populations. Here, we show that phylogenetic analyses of haplogroup C, D and FT sequences, including very rare deep-rooting lineages, together with phylogeographic analyses of ancient and present-day non-African Y chromosomes, all point to East/Southeast Asia as the origin 50,000–55,000 years ago of all known surviving non-African male lineages (apart from recent migrants). This observation contrasts with the expectation of a West Eurasian origin predicted by a simple model of expansion from a source near Africa, and can be interpreted as resulting from extensive genetic drift in the initial population or replacement of early western Y lineages from the east, thus informing and constraining models of the initial expansion.
An expert review on the use of tenofovir alafenamide for the treatment of chronic hepatitis B virus infection in Asia
Authors: Charlton Michael R. , Alam Altaf , Shukla Akash , Dashtseren Bekhbold , Lesmana Cosmas Rinaldi Adithya , Duger Davadoorj , Payawal Diana Alcantara , Duy Cuong Do , Jargalsaikhan Ganbolor , Cua Ian Homer Yee , Sollano Jose Decena , Singh Karam Romeo , Madan Kaushal , Win Khin Maung , Kyi Khin Pyone , Tun Kyaw Soe , Salih Mohd. , Rastogi Mukul , Saraf Neeraj , Thuy Pham Thi Thu , Hien Pham Tran Dieu , Gani Rino Alvani , Mohamed Rosmawati , Tanwandee Tawesak , Piratvisuth Teerha , Sukeepaisarnjaroen Wattana , Naing Win , Hashmi Zahid Yasin 
Published: July 2020

AbstractAsia has intermediate-to-high prevalence and high morbidity of hepatitis B virus (HBV) infection. The use of guideline-recommended nucleos(t)ide analogs with high barrier to resistance, such as entecavir (ETV), tenofovir disoproxil fumarate (TDF), and tenofovir alafenamide (TAF), is one of the key interventions for curbing HBV infection and associated morbidity in Asia. However, there are some challenges to the use of ETV and TDF; while ETV is associated with high resistance in lamivudine (LAM)-exposed (especially LAM-refractory) patients; bone and renal safety issues are a major concern with TDF. Hence, a panel of twenty-eight expert hepatologists from Asia convened, reviewed the literature, and developed the current expert opinion-based review article for the use of TAF in the resource-constrained settings in Asia. This article provides a comprehensive review of two large, phase 3, double-blind, randomized controlled trials of TAF versus TDF in HBeAg-negative (study 0108) and HBeAg-positive (study 0110) chronic HBV patients (> 70% Asians). These studies revealed as follows: (1) non-inferiority for the proportion of patients who had HBV DNA < 29 IU/mL; (2) significantly high rate of normalization of alanine aminotransferase levels; (3) no incidence of resistance; and (4) significantly better bone and renal safety, with TAF vs. TDF up to 144 weeks. Considering the benefits of TAF, the expert panel proposed recommendations for optimizing the use of TAF in Asia, along with guidance on specific patient groups at risk of renal or bone disease suitable for TAF therapy. The guidance provided in this article may help clinicians optimize the use of TAF in Asia.
Microbial-, fusulinid limestones with large gastropods and calcareous algae: an unusual facies from the Early Permian Khao Khad Formation of Central Thailand
Authors: Ketwetsuriya Chatchalerm , Nose Martin , Charoentitirat Thasinee , Nützel Alexander 
Published: July 2020

AbstractThe Early Permian (Kungurian) Khao Khad Formation of Central Thailand consists mostly of carbonates deposited on the western margin of the Indochina Terrane. This formation has yielded unusual microbial-fusulinid limestones with large gastropods which contribute most to the rock volume. With a height of more than 6 cm, the gastropods are amongst the largest Early Permian gastropods ever reported. Gastropods as major rock formers are rare in the Palaeozoic. This, and other recently reported invertebrate faunas from Thailand show that gastropods may dominate Permian fossil assemblages not only in diversity, but also regarding abundance and in some cases also regarding biomass. Besides gastropods, fusulinids, various calcareous algae, intraclasts and thick microbial-cyanobacterial (Girvanella and Archaeolithoporella) coatings and reticular microbial patches as well as thick inter- and intragranular radial fibrous cement crusts are present. The gastropods represent at least four species and belong probably to undescribed taxa. The fusulinid genus Pseudofusulina and Misellina (M.) termieri are reported from the Khao Khad Formation for the first time and indicate a Bolorian age. Calcareous algae are dominated by dasycladaceans followed by gymnocodiaceans and solenoporaceans. The studied limestone almost completely lacks metazoan reef builders such as corals and sponges. Likewise, brachiopods and bivalves are absent in the studied samples and echinoderms are very scarce. The carbonate is interpreted as product of shallow water, back-reef lagoonal platform community with a high productivity providing the large gastropods with sufficient food. However, conditions were too eutrophic for sessile filter feeders including metazoan reef builders.
Fire Safety Assessment of Epoxy Composites Reinforced by Carbon Fibre and Graphene
Authors: Zhang Qiangjun , Wang Yong C , Soutis Constantinos , Bailey Colin G. , Hu Yuan 
Published: July 2020

AbstractThis paper presents a coupled numerical investigation to assess the reaction to fire performance and fire resistance of various types of epoxy resin (ER) based composites. It examines the fire response of carbon fibre (CF) reinforced ER (CF/ER), ER with graphene nanoplatelets (GNP/ER) and CF reinforced GNP/ER (CF/GNP/ER). Thermal, physical and pyrolysis properties are presented to assist numerical modelling that is used to assess the material ability to pass the regulatory vertical burn test for new aircraft structures and estimate in-fire and post-fire residual strength properties.Except for the CF/GNP/ER composite, all other material systems fail the vertical burn test due to continuous burning after removal of the fire source. Carbon fibres are non-combustible and therefore reduce heat release rate of the ER composite. By combining this property with the beneficial barrier effects of graphene platelets, the CF/GNP/ER composite with 1.5 wt% GNP and 50 wt% CF self-extinguishes within 15 s after removal of the burner with a relatively small burn length. Graphene drastically slows down heat conduction and migration of decomposed volatiles to the surface by creating improved char structures. Thus, graphene is allowing the CF/GNP/ER composite panel to pass the regulatory vertical burn test.Due to low heat conduction and reduced heat release rate, the maximum temperatures in the CF/GNP/ER composite are low so the composite material retains very high in-fire and post-fire mechanical properties, maintaining structural integrity. In contrast, temperatures in the CF/ER composite are much higher. At a maximum temperature of 86 °C, the residual in-fire tensile and compressive mechanical strengths of CF/GNP/ER are about 87% and 59% respectively of the ambient temperature values, compared to 70% and 21% respectively for the CF/ER composite that has a temperature of 140 °C at the same time (but the CF/ER temperature will be higher due to continuing burning). Converting mass losses of the composites into char depth, the post-fire mechanical properties of the CF/GNP/ER composite are about 75% of the ambient condition compared to about 68% for the CF/ER composite.
In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase
Authors: Baroni Maurizio D. , Colombo Sonia , Libens Olivier , Pallavi Rani , Giorgio Marco , Martegani Enzo 
Published: July 2020

AbstractCaloric restriction mimetics (CRMs) are promising molecules to prevent age-related diseases as they activate pathways driven by a true caloric restriction. Hydroxycitric acid (HCA) is considered a bona fide CRM since it depletes acetyl-CoA pools by acting as a competitive inhibitor of ATP citrate lyase (ACLY), ultimately repressing protein acetylation and promoting autophagy. Importantly, it can reduce inflammation and tumour development. In order to identify phenotypically relevant new HCA targets we have investigated HCA effects in Saccharomyces cerevisiae, where ACLY is lacking. Strikingly, the drug revealed a powerful anti-aging effect, another property proposed to mark bona fide CRMs. Chronological life span (CLS) extension but also resistance to acetic acid of HCA treated cells were associated to repression of cell apoptosis and necrosis. HCA also largely prevented cell deaths caused by a severe oxidative stress. The molecule could act widely by negatively modulating cell metabolism, similarly to citrate. Indeed, it inhibited both growth reactivation and the oxygen consumption rate of yeast cells in stationary phase. Genetic analyses on yeast CLS mutants indicated that part of the HCA effects can be sensed by Sch9 and Ras2, two conserved key regulators of nutritional and stress signal pathways of primary importance. Our data together with published biochemical analyses indicate that HCA may act with multiple mechanisms together with ACLY repression and allowed us to propose an integrated mechanistic model as a basis for future investigations.
No statistical support for wolf control and maternal penning as conservation measures for endangered mountain caribou
Authors: Harding Lee E. , Bourbonnais Mathieu , Cook Andrew T. , Spribille Toby , Wagner Viktoria , Darimont Chris 
Published: July 2020

AbstractMountain caribou, a behaviourally and genetically distinct set of ecotypes of the Woodland caribou (Rangifer tarandus caribou) restricted to the mountains of western Canada, have undergone severe population declines in recent decades. Although a broad consensus exists that the ultimate driver of these declines has been the reduction of habitat upon which mountain caribou depend, research and policy attention has increasingly focused on predation. Recently, Serrouya et al. (Proc Nat Acad Sci USA 116:6181–6186, 2019) analysed population dynamics data from 18 subpopulations in British Columbia and Alberta, Canada, subject to different treatments and ‘controls’, and concluded that lethal wolf control and maternal caribou penning provide the most effective ways to stabilize population declines. Here we show that this inference was based on an unbalanced analytical approach that omitted a null scenario, excluded potentially confounding variables and employed irreproducible habitat alteration metrics. Our reanalysis of available data shows that ecotype identity is a better predictor of population trends than any adaptive management treatments considered by Serrouya et al. Disparate behavioural characteristics and responses to industrial disturbance among ecotypes suggest it may be incorrect to assume that adaptive management strategies that might benefit one ecotype are transferable to another.
Contemplative insight as an opinion conflict and a search for meaning in the context of innovative elements of the revolution industry 4.0
Authors: Chudy Stefan , Neumeister Pavel , Koribska Iva , Strouhal Martin , Selicka Denisa 
Published: July 2020

AbstractThe aim of this study is to present an insight into the issue of technology and innovation reform with an emphasis on their integration into the social sciences. Using discourse analysis, we have reconstructed the basic elements of reforms and their reflections into a theory that changes not only in terms of content and terminology, but mainly in terms of logic and rationalization of new paradigms. These changes are reflected in the transformation of society, bringing new challenges and defining the relationship between innovation and society. An important outcome of the analysis is pointing out the change in values in society and their reflection in the form of challenges that respect changes in the labor market and educational policies of the various educational institutions.
Six and eight weeks injection frequencies of bevacizumab are non-inferior to the current four weeks injection frequency for quality of life in neovascular age-related macular degeneration: a randomized controlled trial
Authors: Visser Martijn S. , Amarakoon Sankha , Missotten Tom , Timman Reinier , Busschbach Jan J. V. 
Published: July 2020

Abstract
Purpose
Patients with neovascular age-related macular degeneration (nARMD) will not deteriorate on visual acuity and retinal thickness when treated with bevacizumab injection frequencies of 6 or 8 weeks compared to 4 weeks. This study aimed to investigate this non-inferiority in quality of life (QoL). We hypothesized that less frequent bevacizumab injections are not inferior regarding patients reported QoL.

Methods
Patients were randomized to bevacizumab every 4 (n = 64), 6 (n = 63), and 8 weeks (n = 64). Patients were at least 65 years old, have a best-corrected visual acuity of 20/200 to 20/20, no previous ARMD treatment and active leakage. Vision-related QoL questionnaire NEI VFQ-39 was used to assess QoL at baseline and after 1 year. General QoL questionnaire SF-36 was included for secondary analysis. Multilevel analyses were performed, correcting for age, gender and baseline.

Results
The 6 (3.68; 95% CI − 0.63 to 8.00) and 8 (2.15; 95% CI − 2.26 to 6.56) weeks bevacizumab regimens resulted in non-inferior QoL differences compared to 4 weeks on the NEI VFQ-39. Also on the SF-36 the differences were well within the non-inferiority limits.

Conclusion
Non-inferiority of the 6 and 8 weeks frequencies was demonstrated compared to 4 weeks on vision-related and general QoL in patients with nARMD. These results are in line with previously published results of lower frequency injections regarding visual acuity and central retinal thickness. Lower injection frequency may reduce burden, side effects, and treatment costs. In consideration of these results, 8 weeks frequency injections of intravitreal bevacizumab could be considered in patients with nARMD.
Solar Intensity X-Ray and Particle Spectrometer SIXS: Instrument Design and First Results
Authors: Huovelin J. , Vainio R. , Kilpua E. , Lehtolainen A. , Korpela S. , Esko E. , Muinonen K. , Bunce E. , Martindale A. , Grande M. , Andersson H. , Nenonen S. , Lehti J. , Schmidt W. , Genzer M. , Vihavainen T. , Saari J. , Peltonen J. , Valtonen E. , Talvioja M. , Portin P. , Narendranath S. , Jarvinen R. , Okada T. , Milillo A. , Laurenza M. , Heino E. , Oleynik P. 
Published: July 2020

AbstractThe Solar Intensity X-ray and particle Spectrometer (SIXS) on the BepiColombo Mercury Planetary Orbiter (“Bepi”) measures the direct solar X-rays, energetic protons, and electrons that bombard, and interact with, the Hermean surface. The interactions result in X-ray fluorescence and scattering, and particle induced X-ray emission (PIXE), i.e. “glow” of the surface in X-rays. Simultaneous monitoring of the incident and emitted radiation enables derivation of the abundances of some chemical elements and scattering properties of the outermost surface layer of the planet, and it may reveal other sources of X-ray emission, due to, for example, weak aurora-like phenomena in Mercury’s exosphere. Mapping of the Hermean X-ray emission is the main task of the MIXS instrument onboard BepiColombo. SIXS data will also be used for investigations of the solar X-ray corona and solar energetic particles (SEP), both in the cruise phase and the passes of the Earth, Venus and Mercury before the arrival at Mercury’s orbit, and the final science phase at Mercury’s orbit. These observations provide the first-ever opportunity for in-situ measurements of the propagation of SEPs, their interactions with the interplanetary magnetic field, and space weather phenomena in multiple locations throughout the inner solar system far away from the Earth, and more extensively at Mercury’s orbit.In this paper we describe the scientific objectives, design and calibrations, operational principles, and scientific performance of the final SIXS instrument launched to the mission to planet Mercury onboard BepiColombo. We also provide the first analysis results of science observations with SIXS, that were made during the Near-Earth Commissioning Phase and early cruise phase operations in 2018–19, including the background X-ray sky observations and “first light” observations of the Sun with the SIXS X-ray detection system (SIXS-X), and in-situ energetic electron and proton observations with the SIXS Particle detection system (SIXS-P).
Counterpart theories for everyone
Authors: Varzi Achille C. 
Published: July 2020

AbstractDavid Lewis’s counterpart theory (CT) is often seen as involving a radical departure from the standard, Kripke-style semantics for modal logic (ML), suggesting that we are dealing with deeply divergent accounts of our modal talk. However, CT captures but one version of the relevant semantic intuition, and does so on the basis of metaphysical assumptions (all worlds are equally real, individuals are world-bound) that are ostensibly discretionary. Just as ML can be translated into a language that quantifies explicitly over worlds, CT may be formulated as a semantic theory in which world quantification is purely metalinguistic. And just as Kripke-style semantics is formally compatible with the doctrine of world-boundedness, a counterpart-based semantics may in principle allow for cases of trans-world identity. In fact, one may welcome a framework that is general enough to include both Lewis’s counterpart-based account and Kripke’s identity-based account as distinguished special cases. There are several ways of doing so. The purpose of this paper is to outline a fully general option and to illustrate its philosophical significance, showing how the large variety of intermediate relations that lie between Lewisian counterparthood and Kripkean identity yield a corresponding variety of modal theories that would otherwise remain uncharted.
RoCGAN: Robust Conditional GAN
Authors: Chrysos Grigorios G. , Kossaifi Jean , Zafeiriou Stefanos 
Published: July 2020

AbstractConditional image generation lies at the heart of computer vision and conditional generative adversarial networks (cGAN) have recently become the method of choice for this task, owing to their superior performance. The focus so far has largely been on performance improvement, with little effort in making cGANs more robust to noise. However, the regression (of the generator) might lead to arbitrarily large errors in the output, which makes cGANs unreliable for real-world applications. In this work, we introduce a novel conditional GAN model, calledRoCGAN, which leverages structure in the target space of the model to address the issue. Specifically, we augment the generator with an unsupervised pathway, which promotes the outputs of the generator to span the target manifold, even in the presence of intense noise. We prove that RoCGAN share similar theoretical properties as GAN and establish with both synthetic and real data the merits of our model. We perform a thorough experimental validation on large scale datasets for natural scenes and faces and observe that our model outperforms existing cGAN architectures by a large margin. We also empirically demonstrate the performance of our approach in the face of two types of noise (adversarial and Bernoulli).
Energy costs vs. carbon dioxide emissions in short-term production planning
Authors: Dellnitz Andreas , Braschczok Damian , Ostmeyer Jonas , Hilbert Markus , Kleine Andreas 
Published: July 2020

AbstractIn energy-oriented lot-sizing and scheduling research, it is often assumed that minimizing energy costs automatically leads to an improvement of the ecological footprint of a company, i.e., lower carbon dioxide emissions. More precisely, a close to one (positive) correlation between energy costs and carbon dioxide emissions is often supposed. In this contribution, we show that this conjecture does not always hold true due to fluctuating carbon dioxide emissions over the whole day. Therefore, we present a real-world business case study, combining lot-sizing and machine scheduling under time-varying electric energy costsandcarbon dioxide emissions in a mixed integer optimization model; in this context, we also consider on-site power generation. The interplay between all these aspects is demonstrated via a numerical analysis.
Improving Empathy in Healthcare Consultations—a Secondary Analysis of Interventions
Authors: Smith Kirsten A. , Bishop Felicity L. , Dambha-Miller Hajira , Ratnapalan Mohana , Lyness Emily , Vennik Jane , Hughes Stephanie , Bostock Jennifer , Morrison Leanne , Mallen Christian , Yardley Lucy , Everitt Hazel , Little Paul , Howick Jeremy 
Published: July 2020

AbstractA recent systematic review of randomised trials suggested that empathic communication improves patient health outcomes. However, the methods for training healthcare practitioners (medical professionals; HCPs) in empathy and the empathic behaviours demonstrated within the trials were heterogeneous, making the evidence difficult to implement in routine clinical practice. In this secondary analysis of seven trials in the review, we aimed to identify (1) the methods used to train HCPs, (2) the empathy behaviours they were trained to perform and (3) behaviour change techniques (BCTs) used to encourage the adoption of those behaviours. This detailed understanding of interventions is necessary to inform implementation in clinical practice. We conducted a content analysis of intervention descriptions, using an inductive approach to identify training methods and empathy behaviours and a deductive approach to describe the BCTs used. The most commonly used methods to train HCPs to enhance empathy were face-to-face training (n = 5), role-playing (n = 3) and videos (self or model; n = 3). Duration of training was varied, with both long and short training having high effect sizes. The most frequently targeted empathy behaviours were providing explanations of treatment (n = 5), providing non-specific empathic responses (e.g. expressing understanding) and displaying a friendly manner and using non-verbal behaviours (e.g. nodding, leaning forward, n = 4). The BCT most used to encourage HCPs to adopt empathy behaviours was “Instruction on how to perform behaviour” (e.g. a video demonstration, n = 5), followed by “Credible source” (e.g. delivered by a psychologist, n = 4) and “Behavioural practice” (n = 3 e.g. role-playing). We compared the effect sizes of studies but could not extrapolate meaningful conclusions due to high levels of variation in training methods, empathy skills and BCTs. Moreover, the methods used to train HCPs were often poorly described which limits study replication and clinical implementation. This analysis of empathy training can inform future research, intervention reporting standards and clinical practice.