bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep disturbance-related depressive symptom and brain volume reduction in shift-working nurses
Authors: Park Chang-hyun , Bang Mirim , Ahn Kook Jin , Kim Woo Jung , Shin Na-Young 
Published: June 2020

AbstractDisturbed sleep is the most common effect of shift work. A large corpus of research indicates an association between sleep disturbance and depressive symptom in shift workers. In this study, we proposed the mediating role of grey matter (GM) structure in the relationship between sleep disturbance and depressive symptom. We collected structural MRI (sMRI) data as well as assessing the level of sleep disturbance and depressive symptom with the Pittsburgh Sleep disturbance Index and Zung Self-Rating Depression Scale, respectively, in 20 shift-working nurses and 19 day-working nurses. The shift-working nurses reported greater severity of sleep disturbance and depressive symptom, and furthermore, they exhibited reduced GM volume in the left postcentral gyrus (PostCG), right PostCG, right paracentral lobule, and left superior temporal gyrus (STG), compared to the day-working nurses. For each of the four brain regions, we formulated a mediation hypothesis by developing a mediation model that represents a causal chain between GM volume, sleep disturbance, and depressive symptom. Tests of the hypothesis on the mediation of GM volume revealed that inter-individual variations in left PostCG volume and left STG volume accounted for the influence of sleep disturbance on depressive symptom. These results suggest that structural alterations in PostCG and STG play an intervening role in the development of depressive symptom following sleep disturbance. We propose the need of considering neuroanatomical abnormalities in explaining and understanding symptomatic changes induced by sleep disturbance.
Numerical Study of Bacteria Containing Droplets Aerosolized From Hot Surfaces
Authors: Mirskaya Ekaterina , Maksimenko Vladimir , Zagaynov Valery , Agranovski Igor 
Published: June 2020

AbstractThe process of water droplet interaction with hot surface can result in droplet shooting off the surface. When the water is contaminated with bacteria the interaction causes substantial ambient air contamination due to aerosolization of live or injured microorganisms. This study investigates the behaviour of water droplets interacting with heated surfaces in the film boiling regime. A suggested mathematical model considers droplet shooting off conditions and following airborne droplet evolution due to cooling. The critical size of the droplet capable of taking off was modelled as a function of the wall temperature and droplet size. Following the departure from the hot surface, droplet cooling time mainly depends on the initial droplet radius while the influence of the ambient temperature is marginal. The experimental part of the study was focused on (1) investigation of the size of droplets capable of departing from the hot surface, and (2) evaluation of the influence of cooling time on the survivability of two common environmental bacterial species, Gram-negative Escherichia coli and Gram-positive Bacillus subtilis. Droplets with the sizes of up to one millimetre shooting off the hot surfaces were detected, which correlates with the theoretical results. It was found that, under realistic physical conditions, the process of liquid interaction with hot surface does not ensure an efficient microbial inactivation. It was also shown that the shortest cooling time was associated with higher survival rates of both bacterial strains used in this study. However, even for the longest cooling time of 15 seconds the amount of live bacteria in the aerosolized droplet carrier can be substantially high with recovery rates of approximately 50% for B. subtilis.
Potential Impacts of Climate and Land Use Change on the Water Quality of Ganga River around the Industrialized Kanpur Region
Authors: Santy Sneha , Mujumdar Pradeep , Bala Govindasamy 
Published: June 2020

AbstractThe heavily industrialised Kanpur region is the most polluted stretch of the Ganga river because of excessive pollutant discharge from the industries. Agricultural runoff along with climate change further adds to the pollution risk in this industrialised stretch of Ganga. In this paper, we analyse the potential impacts of climate change and land use change on the water quality in this stretch under hypothetical scenarios using the water quality model, QUAL2K. Water quality indicators of Dissolved Oxygen (DO), Biochemical Oxygen Demand, ammonia, nitrate, total nitrogen, organic-, inorganic- and total phosphorous and faecal coliform are assessed for eight climate change and six land use land cover scenarios. Eutrophic conditions are observed in this stretch of the river for all scenarios, implying severe impacts on aquatic life. DO is identified as the most sensitive indicator to the climate change scenarios considered, while nutrients and faecal coliform are more sensitive to the land use scenarios. Increase in agricultural land area leads to larger nutrient concentration while increase in built-up area causes an increase in faecal coliform concentration. Results from this hypothetical study could provide valuable guidance for improving the water quality of the Ganges in future climate change and land use change scenarios.
Isolation and analysis of a non-protein low molecular weight thiol-mercurial adduct from human prostate lymph node cells (LNCaP)
Authors: Gronow Michael 
Published: June 2020

Abstract
Thiol compounds present in human malignant prostate cells (LNCaP) were investigated after reaction with a mercurial blocking reagent. After extracting the cellular glutathione and some other low molecular weight (LMW) thiols using trichloroacetic acid the resulting the protein precipitate was extracted with buffered 8 M urea containing 2-chloromercuri-4-nitrophenol in an equimolar amount to that of the thiol present. After removing the insoluble chromatin fraction the urea soluble labeled adducts formed were chromatographed on G15 Sephadex. Three yellow coloured (A410 nm) fractions were obtained; first, the excluded protein fraction containing 16.0 ± 4.1% of the applied label followed by an intermediate fraction containing 5.9 ± 1.2%. Finally a LMW fraction emerged which contained 77.2 ± 3.7% of the total label applied and this was further analyzed by column chromatography, first on an anion exchange column and then on a PhenylSepharose 6 column to give what appeared to be a single component. LC–MS analysis of this component gave a pattern of mercuri-clusters, formed on MS ionization showing possible parent ions at 704 or 588 m/z, the former indicating that a thiol fragment of molecular weight approximately 467 could be present. No fragments with a single sulfur adduct (a 369 m/z fragment) were observed The adduct was analyzed for cysteine and other amino acids, nucleic acid bases, ribose and deoxyribose sugars, selenium and phosphorus; all were negative leading to the conclusion that a new class of unknown LMW thiol is present concealed in the protein matrices of these cells.
Neutral point potential balancing method for three‐level power converters in two‐stage three‐phase four‐wire power conversion system
Authors: Guo Li , Liu Rui , Li Xialin , Zhang Yun 
Published: June 2020

Two‐stage power conversion system (PCS) for energy storage systems has been considered in islanded operation mode. A three‐level T‐type three‐leg three‐phase four‐wire topology (3LT2 3L3P4W) is employed as AC/DC part and a three‐level buck/boost converter is used as DC/DC interface. This study is mainly focused on balancing the neutral‐point potential (NPP) of the PCS with asymmetrical load connection. An NPP low‐frequency ripple model of 3LT2 3L3P4 inverter is proposed considering various load conditions firstly, which includes detailed expression of low‐frequency ripple components at fundamental frequency and fundamental frequency multipliers. Then, a novel NPP balancing method based on front‐end three‐level buck/boost converter under proportional resonant control is presented, in which the resonance points are set at fundamental frequency and triple fundamental frequency to suppress the dominant components of NPP ripple. Furthermore, a small‐signal model of three‐level buck/boost NPP control system is established and stability analysis is carried out. Simulation and experimental results have been provided to verify the accuracy of the NPP low‐frequency ripple model and the effectiveness of the NPP balancing method.
Wissenswertes zu Dystonien
Authors: Dresel Christian 
Published: June 2020

ZusammenfassungDie Latenz zwischen Manifestation und Diagnose einer primären Dystonie beträgt durchschnittlich mehrere Jahre. Die Diagnose einer primären Dystonie wird durch die Seltenheit der Erkrankung, die Variabilität der klinischen Symptome, die in der Praxis wenig hilfreichen Diagnosekriterien und die Überlappung mit anderen Bewegungsstörungen erschwert. Dieser Artikel gibt einen Überblick über klinische Phänotypen, Pathophysiologie und Therapien primärer Dystonien. Er soll dem Einsteiger und nicht auf Bewegungsstörungen spezialisierten Neurologen Hilfestellungen für den klinischen Alltag geben, um Dystonien frühzeitig zu erkennen und einer Therapie zuzuführen.Der Artikel stellt die 2013 revidierten Diagnosekriterien und die wichtigsten primären Dystonien vor. Pathophysiologisch sind Dystonien durch eine Disinhibition und maladaptive Plastizität in sensomotorischen Hirnnetzwerken charakterisiert. Es ist wichtig, die Dystonie klinisch von anderen Bewegungsstörungen zu differenzieren. Insbesondere eine asymmetrische dystone Haltung der Arme kann ein Frühsymptom einer beginnenden Parkinson-Erkrankung darstellen.Dystonie-Patienten leiden häufig an funktionellen Defiziten, Schmerzen und einer sozialen Stigmatisierung, die zu einer Abnahme der Lebensqualität führen. Therapie der Wahl sind bei fokalen Formen lokale Injektionen von Botulinumtoxin in die dystonen Muskeln und bei multisegmentalen, generalisierten oder therapierefraktären Formen eine Tiefenhirnstimulation des Globus pallidus internus. Beide Therapien führen meist zu einer deutlichen Besserung der dystonen Symptome, einer Linderung der funktionellen Einschränkungen und einer Verbesserung der Lebensqualität. Orale Medikamente haben nur einen geringen Effekt bei ungünstigem Nebenwirkungsprofil und werden nur selten eingesetzt. Begleitend werden Physiotherapie und muskelentspannende Therapien empfohlen, aber der Nachweis für die Wirksamkeit dieser Therapien steht noch aus. Bessere Kenntnisse von Neurologen und Ärzten anderer Fachrichtungen können zu einer früheren Diagnosestellung und effektiveren Therapie von Dystonie-Patienten führen. Ein intensiveres Interesse der Ärzteschaft an diesem Krankheitsbild und eine zunehmende Anzahl an Behandlern und Behandlungszentren können die Versorgung dieser Patienten verbessern.
Psychoonkologie
Authors: Mehnert Anja , Lehmann-Laue Antje 
Published: June 2020

ZusammenfassungKrebs gehört zu den häufigsten Erkrankungen bei Erwachsenen. Trotz einer weltweit steigenden Inzidenz überleben viele Menschen heute die Krankheit. Die multimodalen Therapien, die das Leben verlängern, beeinträchtigen die Lebensqualität von Patienten. Überleben bedeutet deshalb für viele Betroffene auch ein Leben mit körperlichen und psychosozialen Folgeproblemen. Die Psychoonkologie bietet eine evidenzbasierte Versorgung für Patienten und Angehörige an.
Best supportive care bei einer jungen Patientin mit lokal fortgeschrittenem MSI-high-Kolonkarzinom?
Authors: Welland Sabrina , De Castro Tiago , Wirth Thomas , Kleine Moritz , Ringe Kristina Imeen , Saborowski Anna , Vogel Arndt 
Published: June 2020

ZusammenfassungDie molekularpathologische Diagnostik ist von zunehmender Bedeutung für die Therapiesteuerung bei Patienten mit onkologischen Erkrankungen, sowohl hinsichtlich personalisierter als auch hinsichtlich immunonkologischer Konzepte. Ein Beispiel dafür ist die Testung der Tumoren auf den Mikrosatellitenstatus; und der Nachweis einer hochgradigen Mikrosatelliteninstabilität (MSI-high) gilt bereits heute als etablierter, positiv prädiktiver Marker für das Ansprechen auf die Therapie mit Immuncheckpointinhibitoren bei Patienten mit soliden Tumoren. Beeindruckende Daten in diesem Patientenkollektiv haben dazu geführt, dass die amerikanische Food and Drug Administration (FDA) für die Immuntherapie bereits 2017 eine organunabhängige Zulassung bei Patienten mit vorbehandelten MSI-high-Tumoren ausgesprochen hat.Am Beispiel einer jungen Patientin mit Kolonkarzinom demonstrieren wir, dass die Hürde für die Kostenübernahme einer Immuntherapie bei MSI-high-Patienten in Deutschland trotz der überzeugenden Datenlage weiterhin sehr hoch liegt, was zu einem therapeutischen und ethischen Dilemma in der Behandlung onkologischer Patienten führt.
Surgical Treatment of Anterior Communicating Artery Aneurysms: Hints and Precautions for Young Cerebrovascular Surgeons
Authors: Sturiale Carmelo Lucio , Ricciardi Luca , Marchese Enrico , Puca Alfredo , Olivi Alessandro , Albanese Alessio 
Published: June 2020

Abstract
Background Anterior communicating artery (AComA) aneurysms are the most common intracranial aneurysm, accounting for 25 to 38% of all cases. In spite of the advent of modern neurointerventional treatments, they still represent a strong indication for clipping in certain anatomical and clinical conditions. However, AComA aneurysms are the deepest located aneurysms of the anastomotic circle of Willis, with a complex spatial orientation, and they are fed by bilateral branches of the anterior circulations. Although, on one hand, these aneurysms represent the most complex ones of the anterior circulation, on the other hand, the experience of young neurosurgeons is increasingly limited. Therefore, respecting operative guidelines is crucial to achieve the best aneurysm exclusion and avoid fatal intraoperative complications.
Study Objective We describe the technical algorithm we use to teach young neurosurgeons how to approach AComA aneurysms and help them to develop a procedural memory needed to perform an efficient and safe surgery.
Materials and Methods We reviewed our last 10 years of institutional experience of > 200 cases of clipping ruptured and unruptured AComA aneurysms, analyzing our technical refinements and the difficulties in teaching residents and young neurosurgeons how to establish fundamental key points and design a didactic algorithm that includes operative instructions and safety rules.
Results We identified seven pragmatic technical key points regarding craniotomy, cisternostomy, gyrus rectus corticectomy, proximal control, perforators and Heubner preservation, aneurysm neck dissection, and clipping to use in a didactic algorithm for teaching residents and as operative instructions for inexperienced neurosurgeons.
Conclusion In the setting of clipping AComA aneurysms, respect for surgical rules is of paramount importance to perform an efficacious and safe procedure and ensure the best aneurysm exclusion and preservation of neurovascular structures.
Acute Respiratory Decompensation Requiring Intubation in Pregnant Women with SARS-CoV-2 (COVID-19)
Authors: Silverstein Jenna S. , Limaye Meghana A. , Brubaker Sara G. , Roman Ashley S. , Bautista Judita , Chervenak Judith , Ratner Adam J. , Sommer Philip M. , Roselli Nicole M. , Gibson Charlisa D. , Ellenberg David , Penfield Christina A. 
Published: June 2020

AbstractThere is a current paucity of information about the obstetric and perinatal outcomes of pregnant novel coronavirus disease 2019 (COVID-19) patients in North America. Data from China suggest that pregnant women with COVID-19 have favorable maternal and neonatal outcomes, with rare cases of critical illness or respiratory compromise. However, we report two cases of pregnant women diagnosed with COVID-19 in the late preterm period admitted to tertiary care hospitals in New York City for respiratory indications. After presenting with mild symptoms, both quickly developed worsening respiratory distress requiring intubation, and both delivered preterm via caesarean delivery. These cases highlight the potential for rapid respiratory decompensation in pregnant COVID-19 patients and the maternal-fetal considerations in managing these cases.
The emergence of functional case marking in initial varieties of Polish L2
Authors: Saturno Jacopo , Watorek Marzena 
Published: June 2020

Abstract
This paper addresses the acquisition of L2 inflectional morphology after only a few hours of exposure. Eighty-nine
participants with five different L1s and no experience of the L2 took part in a specially designed 14-hour L2 Polish course, during which
they were tested on their developing morphosyntactic skills at various times. The present paper uses a Comprehension task and an Elicited
Imitation task to probe learners’ ability to use nominative and accusative case markings to infer and express the subject and object. The
study is designed to isolate variables such as the task employed to elicit L2 data, target sentence word order, time of exposure to the L2
input, and learners’ L1. The results show that while the majority of learners stick to a word order principle, some managed to identify and
systematically apply the target-like use of inflectional morphology. Various intermediate strategies make it possible to identify a
hierarchy of task difficulty. Both time of exposure and the learner’s L1 proved to be significant predictors of performance.
Potential Use of Pomalaa Nickel Slag as a Substitute for Sand in Brick Making
Authors: Ngii E , Mursidi B , Umar Y Y 
Published: June 2020

AbstractThe latest variance of nickel slag from PT. Antam Pomalaa has that material gradation size equivalent to sand has, so it has potentially as a sand substitute material. The study aims to determine the use of fine nickel slag as a substitute for sand in brick making. Nickel slag used is variation of 0%, 25%, 50%, 75% and 100% against of total weight of sand. The brick is designed with a cement – sand ratio of 1 : 7. The exprimental is a hollow brick with dimension of 40 cm×18 cm×10 cm. Compressive test is done after brick curing along 28 days. The maximum result of compressive test is obtained in the use of 50 % nickel slag of 19.58 kg/cm2compared to the brick without nickel slag of 12.92 kg/cm2. The conclusion that by using a fine nickel slag type of FeNi 4 up to 50 % on production, it can reduce sand use and improve the strength up to 51%.
Carbon Stocks Mapping of Mangrove Forest in North Buton Indonesia using Combination of Landsat and ALOS PALSAR Images in the Perspective of Climate Change Mitigation
Authors: Golok Jaya La Ode Muh. , Yamin Muhammad , Ningrum Ika Purwanti , Safani Jamhir , Wikantika Ketut 
Published: June 2020

Abstract
Mapping of carbon stocks, distribution and its changes become one of the important strategies in climate change mitigation. This study aims to map the carbon stocks of mangrove forests and analyze the changes using a combination of Landsat and ALOS PALSAR images in North Buton, South East Sulawesi Province, Indonesia. Carbon stocks in mangrove forests are known stores several times more than forests in the mainland. Mangrove forest at coast of North Buton is one of the largest area of mangrove forest in south east Sulawesi. The research conducted using backscatter coefficient of HH and HV polarization from ALOS PALSAR and Normalized Difference Vegetation Index (NDVI) from Landsat. The results showed that Landsat image provided information about the distribution, density and change of the carbon stocks during year 2001-2017 while ALOS PALSAR provided the volume of carbon stocks in this region.
Experimental Study on the Performance Characteristics of a Microwave - Solar Heating Dryer
Authors: Mangalla Lukas Kano , Ahmad L O , Lolok A , Delly Jenny , Kadir  , Samhuddin  , Kadir Abdul , Sudia B , Pagiling dan L 
Published: June 2020

Abstract
The use of microwave energy for drying of agricultural products is recently developed due to the advantageous of heating the product much faster and more effective than conventional methods. Moisture content of agricultural product should be evaporated immediately after harvesting in order to inhibit microbial growth and decrease enzymes activity. This work aim to investigate characteristics of microwave-solar hot air drying of agricultural products such as rice grain and potato using a commercial microwave oven and hot air from a can solar collector. A domestic microwave oven was modified in order to operate as a microwave dryer device. The state of the art of microwave-solar heating was developed for investigation on drying performance of agricultural products such as grains and potato slices. Measurements on the temperature of drying chamber and moisture content of the product were conducted under different power inputs of microwave (low, middle and high) and intensity of solar drying. It was observed that microwave-solar air dryer proposed good heating performance and quality of products. Furthermore, temperature, moisture changes and drying rate could be controlled during the drying process.
Floating Houses Technology as Alternative Living on The Water
Authors: Endangsih Tri , Ikaputra  
Published: June 2020

Abstract
Increasing population has resulted in increased housing needs, but currently the available land for housing is decreasing. In addition, climate change has resulted in rising sea levels. With these three problems, it is necessary to develop a place to live with limited land and utilize the potential of Indonesian waters. The efforts that have been made by the current government by building settlements vertically, but have not been able to meet the needs of the residence. One type of house that can be developed by utilizing the potential of the waters is floating houses. A floating house is a residential building that is built on water by applying floating structures, materials, and shapes to suit the construction site. The floating house will function properly with proper planning, especially in the selection of technology at the bottom, floats, and the stability of the building above the water. Besides technology, other things that need to be taken into consideration are the selection of materials and the selection of the type of structure that will be applied. This technological innovation is expected to be able to meet the needs of residences that can utilize the territorial waters.
Design Concept Long Span Bridge with Floating Foundation
Authors: Kadir Abdul , Mursidi Baso 
Published: June 2020

Abstract
Indonesia is a maritime country where the sea area is larger than the land area and consists of a group of islands stretching from west to east. Inter-territorial accsebility can become faster and smoother by structur long span bridges. In the deep sea and tidy ground conditions allow use of pile foundatio, however the floating foundation is an option that can be taken. The purpose of this paper is to propose the concept of a long-span bridge floating foundation that is capable and stable to support the load or forces that work.