bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quasicrystalline phase-change memory
Authors: Lee Eun-Sung , Yoo Joung E. , Yoon Du S. , Kim Sung D. , Kim Yongjoo , Hwang Soobin , Kim Dasol , Jeong Hyeong-Chai , Kim Won T. , Chang Hye J. , Suh Hoyoung , Ko Dae-Hong , Cho Choonghee , Choi Yongjoon , Kim Do H. , Cho Mann-Ho 
Published: August 2020

AbstractPhase-change memory utilizing amorphous-to-crystalline phase-change processes for reset-to-set operation as a nonvolatile memory has been recently commercialized as a storage class memory. Unfortunately, designing new phase-change materials (PCMs) with low phase-change energy and sufficient thermal stability is difficult because phase-change energy and thermal stability decrease simultaneously as the amorphous phase destabilizes. This issue arising from the trade-off relationship between stability and energy consumption can be solved by reducing the entropic loss of phase-change energy as apparent in crystalline-to-crystalline phase-change process of a GeTe/Sb2Te3 superlattice structure. A paradigm shift in atomic crystallography has been recently produced using a quasi-crystal, which is a new type of atomic ordering symmetry without any linear translational symmetry. This paper introduces a novel class of PCMs based on a quasicrystalline-to-approximant crystalline phase-change process, whose phase-change energy and thermal stability are simultaneously enhanced compared to those of the GeTe/Sb2Te3 superlattice structure. This report includes a new concept that reduces entropic loss using a quasicrystalline state and takes the first step in the development of new PCMs with significantly low phase-change energy and considerably high thermal stability.
Antibody-protein binding and conformational changes: identifying allosteric signalling pathways to engineer a better effector response
Authors: Al Qaraghuli Mohammed M. , Kubiak-Ossowska Karina , Ferro Valerie A. , Mulheran Paul A. 
Published: August 2020

AbstractNumerous monoclonal antibodies have been developed successfully for the treatment of various diseases. Nevertheless, the development of biotherapeutic antibodies is complex, expensive, and time-consuming, and to facilitate this process, careful structural analysis beyond the antibody binding site is required to develop a more efficacious antibody. In this work, we focused on protein antigens, since they induce the largest antibody changes, and provide interesting cases to compare and contrast. The structures of 15 anti-protein antibodies were analysed to compare the antigen-bound/unbound forms. Surprisingly, three different classes of binding-induced changes were identified. In class (B1), the antigen binding fragment distorted significantly, and we found changes in the loop region of the heavy chain’s constant domain; this corresponds well with expected allosteric movements. In class (B2), we found changes in the same loop region without the overall distortion. In class (B3), these changes did not present, and only local changes at the complementarity determining regions were found. Consequently, structural analysis of antibodies is crucial for therapeutic development. Careful evaluation of allosteric movements must be undertaken to develop better effector responses, especially during the transformation of these antibodies from small fragments at the discovery stage to full antibodies at the subsequent development stages.
Changes in the core endophytic mycobiome of carrot taproots in response to crop management and genotype
Authors: Abdelrazek Sahar , Choudhari Sulbha , Thimmapuram Jyothi , Simon Philipp , Colley Micaela , Mengiste Tesfaye , Hoagland Lori 
Published: August 2020

AbstractFungal endophytes can influence production and post-harvest challenges in carrot, though the identity of these microbes as well as factors affecting their composition have not yet been determined, which prevents growers from managing these organisms to improve crop performance. Consequently, we characterized the endophytic mycobiome in the taproots of three carrot genotypes that vary in resistance to two pathogens grown in a trial comparing organic and conventional crop management using Illumina sequencing of the internal transcribed spacer (ITS) gene. A total of 1,480 individual operational taxonomic units (OTUs) were identified. Most were consistent across samples, indicating that they are part of a core mycobiome, though crop management influenced richness and diversity, likely in response to differences in soil properties. There were also differences in individual OTUs among genotypes and the nematode resistant genotype was most responsive to management system indicating that it has greater control over its endophytic mycobiome, which could potentially play a role in resistance. Members of the Ascomycota were most dominant, though the exact function of most taxa remains unclear. Future studies aimed at overcoming difficulties associated with isolating fungal endophytes are needed to identify these microbes at the species level and elucidate their specific functional roles.
Advanced MRI features in relapsing multiple sclerosis patients with and without CSF oligoclonal IgG bands
Authors: Zhao Lin , Abrigo Jill , Chen Qianyun , Au Cheryl , Ng Angel , Fan Ping , Mok Vincent , Qiu Wei , Kermode Allan G. , Lau Alexander Y. 
Published: August 2020

AbstractOligoclonal IgG bands (OCB) in cerebrospinal fluid (CSF) are important in diagnosis of multiple sclerosis (MS). We evaluated the MRI features of clinically definite MS subjects with and without CSF-OCB. Relapsing MS subjects were recruited from a prospective registry in a university center. CSF-OCB were detected using isoelectric focusing and lgG-specific immunofixation. MRI metrics including brain volumes, lesion volumes and microstructural measures, were analyzed by FMRIB Software Library (FSL) and Statistical Parametric Mapping (SPM). Seventy-five subjects with relapsing MS were analyzed. Forty-four (59%) subjects had an interval MRI at around 1 year. CSF-OCB were detected in 46 (61%) subjects. The OCB-positive group had a higher proportion of cerebellar lesions than the OCB-negative group (23.9% vs. 3.4%, p = 0.057). Except for amygdala volumes which were lower in the OCB-positive group (p = 0.034), other regional brain volumes including the subcortical deep gray matter and corpus callosum were similar. The two groups also showed comparable brain atrophy rate. For DTI, the OCB-positive group showed significantly higher mean diffusivity (MD) value in perilesional normal-appearing white matter (p = 0.043). Relapsing MS patients with and without CSF-OCB shared similar MRI features regarding volumetric analyses and DTI microstructural integrity.
Responses of active soil microorganisms facing to a soil biostimulant input compared to plant legacy effects
Authors: Hellequin Eve , Monard Cécile , Chorin Marion , Le bris Nathalie , Daburon Virginie , Klarzynski Olivier , Binet Françoise 
Published: August 2020

AbstractAgriculture is changing to rely on agroecological practices that take into account biodiversity, and the ecological processes occurring in soils. The use of agricultural biostimulants has emerged as a valid alternative to chemicals to indirectly sustain plant growth and productivity. Certain BS have been shown to select and stimulate plant beneficial soil microorganisms. However, there is a lack of knowledge on the effects and way of action of the biostimulants operating on soil functioning as well as on the extent and dynamic of these effects. In this study we aimed to decipher the way of action of a seaweed and amino-acids based biostimulant intended to be applied on soil crop residues to increase their microbial mineralization and the further release of nutrients. By setting-up a two-phase experiment (soil plant-growing and soil incubation), our objectives were to (1) determine the effects of the soil biostimulant over time on the active soil bacteria and fungi and the consequences on the organic carbon mineralization in bare soils, and (2) assess the biostimulant effects on soil microorganisms relatively to plant legacy effects in planted soils. We demonstrated that the soil biostimulant had a delayed effect on the active soil microorganisms and activated both plant growth promoting bacteria and saprophytes microorganisms at the medium-term of 49 days. However, the changes in the abundances of active microbial decomposers were not associated to a higher mineralization rate of organic carbon derived from soil and/or litter. The present study assessed the biostimulant beneficial effect on active soil microbial communities as similar as or even higher than the legacy effects of eitherA. thalianaorT. aestivumplants. We specifically showed that the biostimulant increased the active fungal richness to a higher extent than observed in soils that previously grew the two plants tested.
Equilibrium properties of assembly of interacting superparamagnetic nanoparticles
Authors: Usov N. A. , Serebryakova O. N. 
Published: August 2020

AbstractThe stochastic Landau–Lifshitz equation is used to investigate the relaxation process and equilibrium magnetization of interacting assembly of superparamagnetic nanoparticles (SPMNPs) uniformly distributed in a nonmagnetic matrix. For weakly interacting assembly, the equilibrium magnetization is shown to deviate significantly from the Langevin law at moderate and large magnetic fields under the influence of their magnetic anisotropies. For dense assemblies with noticeable influence of the magneto-dipole interaction, a significant dependence of the initial susceptibility on the assembly density is revealed. The difference between the initial susceptibility and the corresponding Langevin susceptibility can serve as an indication of appreciable influence of the magneto-dipole interaction on the assembly properties. A new self-consistent approach is developed to explain the effect of mutual magneto-dipole interaction on the behavior of dense assembly of SPMNPs. The probability densities of the components of random magnetic field acting on magnetic NPs are calculated at thermodynamic equilibrium. The self-consistent probability densities of these components are found to be close to Gaussian distribution. A decreasing equilibrium assembly magnetization as a function of its density can be explained as a disorienting effect of the random magnetic field on the NPs magnetic moments.
A novel nomogram model for differentiating Kawasaki disease from sepsis
Authors: Liu Xiao-Ping , Huang Yi-Shuang , Kuo Ho-Chang , Xia Han-Bing , Yi-Sun  , Huang Wei-Dong , Lang Xin-Ling , Liu Chun-Yi , Liu Xi 
Published: August 2020

AbstractKawasaki disease (KD) is a form of systemic vasculitis that occurs in children under the age of 5 years old. Due to prolonged fever and elevated inflammatory markers that are found in both KD and sepsis, the treatment approach differs for each. We enrolled a total of 420 children (227 KD and 193 sepsis) in this study. Logistic regression and a nomogram model were used to analyze the laboratory markers. We randomly selected 247 children as the training modeling group and 173 as the validation group. After completing a logistic regression analysis, white blood cell (WBC), anemia, procalcitonin (PCT), C-reactive protein (CRP), albumin, and alanine transaminase (ALT) demonstrated a significant difference in differentiating KD from sepsis. The patients were scored according to the nomogram, and patients with scores greater than 175 were placed in the high-risk KD group. The area under the curve of the receiver operating characteristic curve (ROC curve) of the modeling group was 0.873, sensitivity was 0.893, and specificity was 0.746, and the ROC curve in the validation group was 0.831, sensitivity was 0.709, and specificity was 0.795. A novel nomogram prediction model may help clinicians differentiate KD from sepsis with high accuracy.
Radio frequency emissions from dark-matter-candidate magnetized quark nuggets interacting with matter
Authors: VanDevender J. Pace , Buchenauer C. Jerald , Cai Chunpei , VanDevender Aaron P. , Ulmen Benjamin A. 
Published: August 2020

AbstractQuark nuggets are theoretical objects composed of approximately equal numbers of up, down, and strange quarks. They are also called strangelets, nuclearites, AQNs, slets, Macros, and MQNs. Quark nuggets are a candidate for dark matter, which has been a mystery for decades despite constituting ~ 85% of the universe’s mass. Most previous models of quark nuggets have assumed no intrinsic magnetic field; however, Tatsumi found that quark nuggets may exist in magnetars as a ferromagnetic liquid with a magnetic field BS = 1012±1 T. We apply that result to quark nuggets, a dark-matter candidate consistent with the Standard Model, and report results of analytic calculations and simulations that show they spin up and emit electromagnetic radiation at ~ 104 to ~ 109 Hz after passage through planetary environments. The results depend strongly on the value of Bo, which is a parameter to guide and interpret observations. A proposed sensor system with three satellites at 51,000 km altitude illustrates the feasibility of using radio-frequency emissions to detect 0.003 to 1,600 MQNs, depending on Bo, during a 5 year mission.
Active and social life is associated with lower non-social fearfulness in pet dogs
Authors: Hakanen Emma , Mikkola Salla , Salonen Milla , Puurunen Jenni , Sulkama Sini , Araujo César , Lohi Hannes 
Published: August 2020

AbstractBehavioural problems are leading welfare issues in domestic dogs. In particular, anxiety-related behavioural problems, such as fearfulness and noise sensitivity are highly prevalent conditions that cause distress to fearful dogs. To better understand the environmental factors associated with non-social fear, including noise sensitivity, fear of novel situations, and fear of surfaces and heights, a large online survey including data on 13,700 Finnish pet dogs was performed by the dog owners. After fulfilling inclusion criteria, this data consisted of 9,613 dogs with fear of fireworks, 9,513 dogs with fear of thunder, 6,945 dogs with fear of novel situations, and 2,932 dogs with fear of surfaces and heights. Logistic regression analyses revealed that dogs with frequent non-social fear had experienced less socialisation during puppyhood, were more often neutered, had inexperienced owners, lived without conspecifics, participated less frequently in activities or training, and lived in more urban environments. In addition, we identified several breed differences, and a tendency of more common non-social fear in small dog breeds, which suggests a genetic background. Non-social fearfulness has a negative effect on well-being of the dogs. Our findings suggest that the socialisation and the living environment and the value of other dogs’ company and owner interaction via activities and training may improve the well-being of the dogs.
Parental psychological distress in the postnatal period in Japan: a population-based analysis of a national cross-sectional survey
Authors: Takehara Kenji , Suto Maiko , Kato Tsuguhiko 
Published: August 2020

AbstractMental health assessments of both members of a couple are important when considering the child-rearing environment. The prevalence and factors associated with both parents’ psychological distress have not been fully investigated. A nationally representative sample from the 2016 Comprehensive Survey of Living Conditions in Japan was used to examine the prevalence of moderate and severe psychological distress in parents in the first year after childbirth. In total, 3,514 two-parent households raising children under one year old met the study criteria. The Japanese version of Kessler 6 was used to assess moderate and severe psychological distress. The prevalence of either or both parents experiencing psychological distress in the first year after birth were 15.1% and 3.4%, respectively. A multivariate logistic regression analysis showed factors of fathers who worked ≥ 55 h a week, reduced duration of sleep in mothers, age in months of the youngest child, and high household expenditures were significantly associated with both parents simultaneously having moderate or severe psychological distress. This study implied the importance of prevention and early detection of parental psychological distress in both parents. Assessing parents’ psychological distress and work-style reform in the childcare period is an urgent issue to improve their mental health conditions.
Collagen VIα2 chain deficiency causes trabecular bone loss by potentially promoting osteoclast differentiation through enhanced TNFα signaling
Authors: Pham Hai T. , Kram Vardit , Dar Qurratul-Ain , Komori Taishi , Ji Youngmi , Mohassel Payam , Rooney Jachinta , Li Li , Kilts Tina M. , Bonnemann Carsten , Lamande Shireen , Young Marian F. 
Published: August 2020

AbstractType VI collagen is well known for its role in muscular disorders, however its function in bone is still not well understood. To examine its role in bone we analyzed femoral and vertebral bone mass by micro-computed tomography analysis, which showed lower bone volume/total volume and trabecular number in Col6α2-KO mice compared with WT. Dynamic histomorphometry showed no differences in trabecular bone formation between WT and Col6α2-KO mice based on the mineral appositional rate, bone formation rate, and mineralizing perimeter. Femoral sections were assessed for the abundance of Tartrate Resistant Acid Phosphatase-positive osteoclasts, which revealed that mutant mice had more osteoclasts compared with WT mice, indicating that the primary effect of Col6a2 deficiency is on osteoclastogenesis. When bone marrow stromal cells (BMSCs) from WT and Col6α2-KO mice were treated with rmTNFα protein, the Col6α2-KO cells expressed higher levels of TNFα mRNA compared with WT cells. This was accompanied by higher levels of p-p65, a down-stream target of TNFα, suggesting that BMSCs from Col6α2-KO mice are highly sensitive to TNFα signaling. Taken together, our data imply that Col6a2 deficiency causes trabecular bone loss by enhancing osteoclast differentiation through enhanced TNFα signaling.
Abdominal aorta diameter as a novel marker of diabetes incidence risk in elderly women
Authors: Dereziński Tadeusz , Zozulińska-Ziółkiewicz Dorota , Uruska Aleksandra , Dąbrowski Mariusz 
Published: August 2020

AbstractThe prevalence of diabetes mellitus is increasing worldwide, including the nation of Poland. The aim of this prospective and observational study was to determine risk factors and the predictors of diabetes incidence in elderly women, and to calculate the diabetes incidence ratio in this population. Two-hundred women, aged 65–74, who were non-diabetic at baseline in 2012 were followed for 6.5 years. All women were checked for incident diabetes. In non-diabetic subjects, diagnostic procedures for diabetes were performed according to Poland’s Diabetes recommendations. Between April 2012 and September 2018, 25 women developed diabetes and the next 11 cases were diagnosed based on FPG or oral glucose tolerance test. Women with incident diabetes had significantly higher baseline FPG, triglycerides (TG), TG/HDL cholesterol ratio and visceral adiposity index (VAI) score, and lower abdominal aorta diameter (AAD), HDL cholesterol and eGFR. In the Cox proportional hazard regression analysis, only AAD < 18 mm and VAI score ≥ 3.8 were independently associated with diabetes risk, hazard ratio (HR) 2.47 (95% confidence interval 1.21–5.02), P = 0.013 and HR 2.83 (1.35–5.94), P = 0.006 respectively. In the backward stepwise regression analysis including all variables, diabetes incidence could be predicted from a linear combination of the independent variables: AAD < 18 mm (P = 0.002), VAI score ≥ 3.8 (P < 0.001) and FPG ≥ 5.6 mmol/L (P = 0.011). The calculated incidence of diabetes was 2769.2 new cases/100,000 persons per year. AAD below 18 mm seem to be a novel, independent marker of diabetes risk in elderly women, and AAD assessment during routine abdomen ultrasound may be helpful in identifying females at early elderliness with high risk of diabetes incidence.
Six to 12-year outcomes of magnetic sphincter augmentation for gastroesophageal reflux disease
Authors: Ferrari Davide , Asti Emanuele , Lazzari Veronica , Siboni Stefano , Bernardi Daniele , Bonavina Luigi 
Published: August 2020

AbstractThe magnetic sphincter augmentation (MSA) device has been proven safe and effective in controlling typical reflux symptoms and esophageal acid exposure for up to 6-year follow-up. Longer term outcomes have not been reported yet. A prospectively maintained database was reviewed to assess long-term safety and efficacy of the laparoscopic MSA procedure at a single referral center. Gastro-Esophageal Reflux Disease-Health Related Quality of Life (GERD-HRQL), use of proton-pump inhibitors (PPI), and esophageal acid exposure were compared to baseline. Favorable outcomes were defined as ≥ 50% improvement of GERD-HRQL total score and PPI discontinuation. Between March 2007 and March 2020, 335 patients met the study inclusion criteria, and 124 of them were followed from 6 to 12 years after surgery (median 9 years, IQR 2). Mean total GERD-HRQL score significantly improved from 19.9 to 4.01 (p < 0.001), and PPI were discontinued by 79% of patients. The mean total percent time with pH < 4 decreased from 9.6% at baseline to 4.1% (p < 0.001), with 89% of patients achieving pH normalization. Independent predictors of a favorable outcome were age at intervention < 40 years (OR 4.17) and GERD-HRQL score > 15 (OR 4.09). We confirm long-term safety and efficacy of MSA in terms of symptom improvement, decreased drug dependency, and reduced esophageal acid exposure.
Autologous transplantation of adipose-derived stromal cells combined with sevoflurane ameliorates acute lung injury induced by cecal ligation and puncture in rats
Authors: Liang Zuodi , Zhou Heng , Tang Rurong , Zhang Shuo , Chen Xiaohuan , Pei Ling 
Published: August 2020

AbstractAdipose-derived stromal cells (ADSCs) have excellent capacities for regeneration and tissue protection, while sevoflurane, as a requisite component of surgical procedures, has shown therapeutic benefit in animal models of sepsis. This study therefore determined if the combination of sevoflurane and ADSCs exerted additional protective effects against acute lung injury (ALI) induced by cecal ligation and puncture (CLP) in rats. The animals were randomized into five groups: (sham operation (group I), CLP followed by mechanical ventilation (group II), CLP plus sevoflurane at 0.5 minimum alveolar concentration (group III), CLP plus intravenous autologous 5 × 106 ADSCs (group IV), and CLP plus sevoflurane and ADSCs (group V). Levels of the pro-inflammatory cytokines tumor necrosis factor-α, transforming growth factor-β1, interleukin-1β and interleukin-6 were significantly increased in CLP rats. Moreover, epithelial sodium channel expression levels and activities of Na/K-ATPase and alveolar fluid clearance were significantly reduced in CLP-induced ALI rats. ADSCs improved all these parameters, and these effects were further enhanced by the addition of sevoflurane. In conclusion, combined treatment with ADSCs and sevoflurane is superior to either ADSCs or sevoflurane therapy alone for preventing ALI. This beneficial effect may be partly due to improved alveolar fluid clearance by the paracrine or systemic production of keratinocyte growth factor and via anti-inflammatory properties.