bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing Systematic Impacts of PBL Schemes on Storm Evolution in the NOAA Warn-on-Forecast System
Authors: Potvin Corey K. , Skinner Patrick S. , Hoogewind Kimberly A. , Coniglio Michael C. , Gibbs Jeremy A. , Clark Adam J. , Flora Montgomery L. , Reinhart Anthony E. , Carley Jacob R. , Smith Elizabeth N. 
Published: April 2020

Abstract
The NOAA Warn-on-Forecast System (WoFS) is an experimental rapidly updating convection-allowing ensemble designed to provide probabilistic operational guidance on high-impact thunderstorm hazards. The current WoFS uses physics diversity to help maintain ensemble spread. We assess the systematic impacts of the three WoFS PBL schemes—YSU, MYJ, and MYNN—using novel, object-based methods tailored to thunderstorms. Very short forecast lead times of 0–3 h are examined, which limits phase errors and thereby facilitates comparisons of observed and model storms that occurred in the same area at the same time. This evaluation framework facilitates assessment of systematic PBL scheme impacts on storms and storm environments. Forecasts using all three PBL schemes exhibit overly narrow ranges of surface temperature, dewpoint, and wind speed. The surface biases do not generally decrease at later forecast initialization times, indicating that systematic PBL scheme errors are not well mitigated by data assimilation. The YSU scheme exhibits the least bias of the three in surface temperature and moisture and in many sounding-derived convective variables. Interscheme environmental differences are similar both near and far from storms and qualitatively resemble the differences analyzed in previous studies. The YSU environments exhibit stronger mixing, as expected of nonlocal PBL schemes; are slightly less favorable for storm intensification; and produce correspondingly weaker storms than the MYJ and MYNN environments. On the other hand, systematic interscheme differences in storm morphology and storm location forecast skill are negligible. Overall, the results suggest that calibrating forecasts to correct for systematic differences between PBL schemes may modestly improve WoFS and other convection-allowing ensemble guidance at short lead times.
Acute and episodic vestibular syndromes caused by ischemic stroke: predilection sites and risk factors
Authors: Tong DaoMing , Chen XiaoDong , Wang YuanWei , Wang Ying , Du Li , Bao JunJie 
Published: April 2020

Objective This study was performed to investigate the predilection sites of acute vestibular syndrome (AVS) and episodic vestibular syndrome (EVS) caused by acute infarcts. Methods This retrospective cohort study was performed at a stroke center in a tertiary teaching hospital. We diagnosed patients with AVS/EVS caused by acute ischemic stroke using diffusion-weighted imaging (DWI) and magnetic resonance angiography. Results Among all patients with AVS/EVS, 68 had DWI-positive ischemic events and 113 had DWI-negative ischemic events. Of the 68 patients with positive DWI findings, 42.6% had acute infarcts in the anterior circulation and 41.2% had acute infarcts in the posterior circulation. The main stroke predilection sites were the insular cortex (22.1%) and posterior thalamus (11.8%). Large vessel stenosis/occlusion (odds ratio, 0.12; 95% confidence interval, 0.04–0.36) and focal neurological symptoms/signs (odds ratio, 0.27; 95% confidence interval, 0.10–0.72) were significantly associated with the risk of AVS/EVS in patients with acute ischemic stroke. Conclusions The main predilection sites of AVS/EVS caused by ischemic stroke are the insular cortex and posterior thalamus. The risk of AVS/EVS is associated with large vessel stenosis and focal symptoms.
Modified relative dose response values differ between lactating women in the United States and Indonesia
Authors: Sheftel Jesse , Bresnahan Kara A , Fadjarwati Tetra , Tanumihardjo Sherry A 
Published: April 2020

The modified relative dose response (MRDR) test distinguishes between vitamin A (VA) deficiency and sufficiency using the molar ratio of 3,4-didehydroretinol to retinol (DR:R) in serum 4–6 h after administering 3,4-didehydroretinyl acetate (DRA). Research in sows demonstrated that serum and milk DR:R are correlated. Two studies determined VA status in lactating women and investigated breast milk as a surrogate for serum in the MRDR test in VA-adequate women. A secondary outcome compared serum with milk carotenoids in US women. Lactating US (24–40 years old, n =  25) and Indonesian (22–40 years old, n =  18) women were given 8.8 µmol DRA. Subjects were allocated to three collections (3–48 h post-dose) for blood and milk ( n =  4–10/time point). DR, retinol, and carotenoids were determined by HPLC. Serum DR:R time-courses were evaluated in all women and DR kinetics analyzed by noncompartmental modeling in the US and VA-deficient Indonesian women. Indonesian women had a higher proportion of VA deficiency by MRDR (61%) than US women (0%). Milk DR concentration was higher than serum. In US women, serum and milk DR:R were correlated at 5 h ( r =  0.86, P <  0.01) but not at 6 or 7 h. Serum DR kinetics ( tmax = 8, t1/2 = 15.3 h) were similar to those in VA-adequate lactating sows ( tmax = 7.5 ± 1.9, t1/2 = 17.4 ± 4.5 h) but varied in milk (human: tmax = 12, t1/2 = 22.4 h; sow: tmax = 14.4 ± 9.8, t1/2 = 71.8 ± 51.2 h). Carotenoids in milk differed from serum ( P <  0.001), with β-cryptoxanthin enrichment. Serum but not milk VA kinetics were similar between women and sows. Milk DR:R may represent a simpler VA biomarker in lactating women vulnerable to VA deficiency, but requires further validation. Impact statement Vitamin A (VA) deficiency is a major health issue globally, and lactating women are particularly vulnerable due to increased needs for milk production. Accurate detection of VA deficiency is important; however, most population surveys measure VA status using serum retinol, which is affected by inflammation and lacks sensitivity. The modified relative dose response (MRDR) test qualitatively distinguishes between VA deficiency and sufficiency and could improve population surveys if completed in a randomly selected subsample of individuals in surveys. The original relative dose response test required two blood samples, while MRDR requires only one, a significant improvement in accessibility of the technique by decreasing burden on subjects and investigators. This work demonstrates significant deficiency in Indonesian women compared with US women. In combination with previous research using lactating sows, these human data support milk as a surrogate for blood in the MRDR, which may be less invasive, but requires further validation.
Bone Graft Harvesting From the Calcaneus Using Lateral Wall Corticotomy Technique by an Osteotome
Authors: Khademi Farough , Erfani Amirhossein , Erfani Mohammad Ali , Vosoughi Amir Reza 
Published: April 2020

Background: The aim of this study was to evaluate the complications following calcaneal autologous bone graft harvesting using an osteotome in patients who underwent foot and ankle surgery with follow-up of at least 1 year. Methods: In a cohort study, all consecutive patients underwent forefoot or midfoot surgeries in conjunction with harvesting bone graft from the calcaneus using lateral wall corticotomy technique by an osteotome from 2015 till 2018 were asked to follow. The outcome and morbidity were assessed by visual analogue scale (VAS) pain, numbness in territory of the sural nerve, surgical site numbness or tenderness, infection, hematoma formation, or pathologic fracture. Also any possible restrictions on wearing desired shoes were asked. Results: Totally, 50 patients (11 males, 39 females; 29 right foot, 21 left foot) with the mean age of 48.2 ± 13.8 years (range 8-66 years) were assessed. There were no major complications on donor site such as infection, hematoma formation, or pathologic fracture. The following results were seen; 90% without any pain (VAS 0/10), 96% without numbness at the incision site, 96% without point tenderness on lateral of heel, 98% without paresthesia or numbness in the sural nerve territory, and 84% were able to wear their favorite shoes. Forty-one (82%) cases said if they need another foot surgery, they would permit to harvest bone graft from their heel. Conclusions: Autologous bone graft harvesting from the calcaneus using lateral wall corticotomy technique by an osteotome could be a useful method with very low complications. Levels of Evidence: Therapeutic, level IV: cohort, case series
Clinical Characteristics and Outcomes After Primary ACL Reconstruction and Meniscus Ramp Repair
Authors: DePhillipo Nicholas N. , Dornan Grant J. , Dekker Travis J. , Aman Zachary S. , Engebretsen Lars , LaPrade Robert F. 
Published: April 2020

Background: Satisfactory outcomes have been reported after all-inside meniscus ramp repair with combined anterior cruciate ligament reconstruction (ACLR). However, clinical outcomes after ACLR with inside-out meniscus ramp repair are limited. Purpose/Hypothesis: The purpose of this study was to evaluate patient-reported outcomes for patients who underwent ACLR and medial meniscus ramp repair compared with those who underwent isolated ACLR; patients in the 2 groups were matched for age, sex, and sport/activity. The null hypothesis was that there would be no significant differences in clinical outcomes between groups at a minimum of 2 years postoperatively. Study Design: Cohort study; Level of evidence 3. Methods: Patients who underwent primary ACLR with bone–patellar tendon–bone (BPTB) autograft by a single surgeon were retrospectively identified. A subgroup of patients with combined ACLR and meniscus ramp repair with a minimum 2-year postoperative follow-up were matched to a cohort who underwent isolated ACLR. Subjective patient-reported questionnaires, knee stability, and return to level of activity/sport were collected. Results: There were 851 patients who underwent primary ACLR; of these, 158 (18.6%) had medial meniscus ramp lesions confirmed at arthroscopy. The most common clinical characteristics in patients with ramp lesions were chronic injuries (68.4%), contact mechanism (88%), concomitant lateral meniscus tears (63.2%), and concomitant lateral meniscus posterior root tears (22.2%). Further, 50 patients who underwent combined ACLR and meniscus ramp repair with minimum 2-year follow-up were matched to patients who underwent isolated ACLR. Both groups reported significant improvements in subjective outcomes from preoperative to postoperative assessments ( P < .001). No significant differences were found in postoperative outcomes for combined ACLR with ramp repair versus isolated ACLR ( P > .05). Patients with meniscus ramp repair had increased preoperative knee laxity demonstrated by grade 3 Lachman (44% vs 6%) and pivot-shift (38% vs 12%) test results compared with patients who underwent isolated ACLR ( P ≤ .005 for both). Conclusion: This study demonstrates similar clinical outcomes, knee stability on postoperative physical examination, and return-to-sport rates for patients who underwent combined ACLR with BPTB autograft and inside-out meniscus ramp repair versus a matched cohort who underwent isolated ACLR. Clinicians should have a high index of suspicion for the presence of ramp lesions in patients with ACL tears who have a contact mechanism of injury, grade 3 Lachman test result, and concomitant lateral meniscal abnormality.
Langhofite, Pb2(OH)[WO4(OH)], a new mineral from Långban, Sweden
Authors: Holtstam Dan , Cámara Fernando , Karlsson Andreas 
Published: April 2020

AbstractLanghofite, ideally Pb2(OH)[WO4(OH)], is a new mineral from the Långban mine, Värmland, Sweden. The mineral and its name were approved by the International Mineralogical Association Commission on New Minerals, Nomenclature and Classification (IMA2019-005). It occurs in a small vug in hematite–pyroxene skarn associated with calcite, baryte, fluorapatite, mimetite and minor sulfide minerals. Langhofite is triclinic, space group P$\bar{1}$, and unit-cell parameters a = 6.6154(1) Å, b = 7.0766(1) Å, c = 7.3296(1) Å, α = 118.175(2)°, β = 94.451(1)°, γ = 101.146(1)° and V = 291.06(1) Å3 for Z = 2. The seven strongest Bragg peaks from powder X-ray diffractometry are [dobs, Å (I)(hkl)]: 6.04(24)(010), 3.26(22)(11$\bar{2}$), 3.181(19)(200), 3.079(24)(1$\bar{1}$2), 3.016(100)(020), 2.054(20)(3$\bar{1}$1) and 2.050(18)(13$\bar{2}$). Langhofite occurs as euhedral crystals up to 4 mm, elongated along the a axis, with lengthwise striation. Mohs hardness is ca. 2½, based on VHN25 data obtained in the range 130–192. The mineral is brittle, with perfect {010} and {100} cleavages. The calculated density based on the ideal formula is 7.95(1) g⋅cm–3. Langhofite is colourless to white (non-pleochroic) and transparent, with a white streak and adamantine lustre. Reflectance curves show normal dispersion, with maximum values 15.7–13.4% within 400–700 nm. Electron microprobe analyses yield only the metals Pb and W above the detection level. The presence of OH-groups is demonstrated with vibration spectroscopy, from band maxima present at ~3470 and 3330 cm–1. A distinct Raman peak at ca. 862 cm–1 is related to symmetric W–oxygen stretching vibrations. The crystal structure is novel and was refined to R = 1.6%. It contains [W2O8(OH)2]6– edge-sharing dimers (with highly distorted WO6-octahedra) forming chains along [101] with [(OH)2Pb4]6+ dimers formed by (OH)Pb3 triangles. Chains configure (010) layers linked along [010] by long and weak Pb–O bonds, thus explaining the observed perfect cleavage on {010}. The mineral is named for curator Jörgen Langhof (b. 1965), who collected the discovery sample.
Mortality among children under five years admitted for routine care of severe acute malnutrition: a prospective cohort study from Kampala, Uganda
Authors: Nalwanga Damalie , Musiime Victor , Kizito Samuel , Kiggundu John Baptist , Batte Anthony , Musoke Philippa , Tumwine James K. 
Published: April 2020

AbstractBackgroundMortality among children under 5 years of age admitted to malnutrition units in sub-Saharan Africa remains high. The burden of HIV infection, a major risk factor for mortality among patients with severe acute malnutrition (SAM), has reduced due to concerted prevention and treatment strategies. None the less, anecdotal reports from the malnutrition unit at Uganda’s National Referral Hospital (NRH) indicate that there is high mortality among patients with severe acute malnutrition (SAM) in routine care. Uganda has recently adopted the revised World Health Organization (WHO) treatment guidelines for SAM to improve outcomes. The mortality among children with SAM in routine care has not been recently elucidated. We report the magnitude and factors associated with mortality among children under 5 years of age admitted to the NRH for routine care of SAM.MethodsThis was a cohort study of all severely malnourished children admitted to the NRH between June and October 2017. The primary outcome was two-week mortality. Mortality was calculated using simple proportions and Cox regression analysis was used to determine factors associated with time to mortality. Data was entered into Epidata and analysed using Stata v14.ResultsTwo-hundred-sixty (98.5%) children: 59.6% male; mean age 14.4 (SD 9.4) months, completed two weeks of follow-up. Of these, 25.2% (95% CI 19.9–30.4%) died. In-hospital mortality was 20.7% (95% CI15.9–25.6%). The prevalence of HIV infection was 12.2%. Factors associated with mortality included: positive HIV status (AHR 2.2, (95% CI; 1.2–4.2),p = 0.014), bacteraemia (AHR 9 (95% CI 3.4–23.0),p < 0.001, and low glomerular filtration rate (eGFR), AHR 3.2; (95% CI 1.7–6.3),p = 0.001).ConclusionsA 25% mortality among children with severe malnutrition remains unacceptably high despite significant reduction in HIV prevalence. Children with SAM who are HIV infected, have eGFR below 60 mL/min/1.73m2or have bacteraemia, are more likely to die. Further studies to explore the relationship between eGFR and mortality among children with SAM are needed. Studies to establish efficacious antibiotics are urgently required to inform treatment guidelines for children with SAM.
Strengthening prehospital clinical practice guideline implementation in South Africa: a qualitative case study
Authors: McCaul Michael , Young Taryn , Bruijns Stevan R. , Clarke Mike 
Published: April 2020

Abstract
Background
Methods on developing new (de novo) clinical practice guidelines (CPGs) have received substantial attention. However, research into alternative methods of CPG development using existing CPG documents (CPG adaptation) — a specific issue for guideline development groups in low- and middle-income countries — is sparse. There are only a few examples showcasing the pragmatic application of such alternative approaches in settings with time and budget constraints, especially in the prehospital setting. This paper aims to describe and strengthen the methods of developing prehospital CPGs using alternative guideline development methods through a case study design.

Methods
We qualitatively explored a CPG development project conducted in 2016 for prehospital providers in South Africa as a case study. Key stakeholders, involved in various processes of the guideline project, were purposefully sampled. Data were collected from one focus group and six in-depth interviews and analysed using thematic analysis. Overarching themes and sub-themes were inductively developed and categorised as challenges and recommendations and further transformed into action points.

Results
Key challenges revolved around guideline implementation as opposed to development. These included the unavoidable effect of interest and beliefs on implementing recommendations, the local evidence void, a shifting implementation context, and opposing end-user needs. Guideline development and implementation strengthening priority actions included: i) developing a national end-user document; ii) aligning recommendations with local practice; iii) communicating a clear and consistent message; iv) addressing controversial recommendations; v) managing the impact of interests, beliefs and intellectual conflicts; and vi) transparently reporting implementation decisions.

Conclusion
The cornerstone of a successful guideline development process is the translation and implementation of CPG recommendations into clinical practice. We highlight key priority actions for prehospital guideline development teams with limited resources to strengthen guideline development, dissemination, and implementation by drawing from lessons learnt from a prehospital guideline project conducted in South Africa.
Exosomal miRNAs in hepatitis B virus related liver disease: a new hope for biomarker
Authors: Bandopadhyay Manikankana , Bharadwaj Mausumi 
Published: April 2020

AbstractThe World Health Organisation, in its 2019 progress report on HIV, viral hepatitis and STDs indicates that 257 million people are afflicted with chronic HBV infections, of which, 1 million patients lose their lives every year due to HBV related chronic liver diseases including serious complications such as liver cirrhosis and hepatocellular carcinoma. The course of HBV infection and associated liver injury depend on several host factors, genetic variability of the virus, and the host viral interplay. The challenge of medical science is the early diagnosis/identification of the potential for development of fatal complications like liver cirrhosis and HCC so that timely medical intervention can improve the chances of survival. Currently, neither the vaccination regime nor the diagnostic methods are completely effective as reflected in the high number of annual deaths. It is evident from numerous publications that microRNAs (miRNAs) are the critical regulators of gene expression and various cellular processes like proliferation, development, differentiation, apoptosis and tumorigenesis. Expressions of these diminutive RNAs are significantly affected in cancerous tissues as a result of numerous genomic and epigenetic modifications. Exosomes are membrane-derived vesicles (30–100 nm) secreted by normal as well as malignant cells, and are present in all body fluids. They are recognized as critical molecules in intercellular communication between cells through horizontal transfer of information via their cargo, which includes selective proteins, mRNAs and miRNAs. Exosomal miRNAs are transferred to recipient cells where they can regulate target gene expression. This provides an insight into the elementary biology of cancer progression and therefore the development of therapeutic approaches. This concise review outlines various on-going research on miRNA mediated regulation of HBV pathogenesis with special emphasis on association of exosomal miRNA in advanced stage liver disease like hepatocellular carcinoma. This review also discusses the possible use of exosomal miRNAs as biomarkers in the early detection of HCC and liver cirrhosis.
Development of a standardized method to evaluate the protective efficiency of cosmetic packaging against microbial contamination
Authors:   the members of the Cosmetic Valley EPMP commission, Catovic Chloe , Martin Sylvia , Desaint Stéphane , Borges Christine , Lesouhaitier Hélène , Roullet Florence , Bresciani Nadine , Jouault Anne-Marie , Poulet Valérie , Luc Joelle , Joulia Valérie , Jupin Alain , Masson Christophe , Crozier Alain , Feuilloley Marc G. J. 
Published: April 2020

AbstractDoubts surrounding the potential adverse effects of antimicrobial preservatives have modified the demand of consumers, who increasingly insist on the production of low-level and even preservative-free cosmetics. Protection of the product against microbial contamination is therefore focused on the packaging. This has prompted the emergence of a highly diverse array of so-called “protective”, “overprotective”, and “barrier” packaging. However, these designations are not normalized and the choice of the right packaging adapted to each cosmetic product is still essentially empirical, hazardous, and time consuming. The Cosmetic Valleys cluster has launched a commission to define a complete and experimentally-validated method to classify the level of protection of cosmetic packaging against microbial contamination. As reported herein, this required the development a specific bacteriostatic medium that can be used for 7 days and an in vitro procedure that reproduces in-use contamination and consumer practices. Based on tests performed on over 800 packages of different origin and performance characteristics, we propose a classification, divided into six grades, to differentiate the protective efficiency of cosmetic packaging. This work can be considered as a first step towards a regulatory text.