bluuebunny/crossref_metadata_2025_split huggingface dataset:
Galaxy and mass assembly: luminosity and stellar mass functions in GAMA groups
Authors: Vázquez-Mata J A , Loveday J , Riggs S D , Baldry I K , Davies L J M , Robotham A S G , Holwerda B W , Brown M J I , Cluver M E , Wang L , Alpaslan M , Bland-Hawthorn J , Brough S , Driver S P , Hopkins A M , Taylor E N , Wright A H 
Published: September 2020

ABSTRACT
How do galaxy properties (such as stellar mass, luminosity, star formation rate, and morphology) and their evolution depend on the mass of their host dark matter halo? Using the Galaxy and Mass Assembly group catalogue, we address this question by exploring the dependence on host halo mass of the luminosity function (LF) and stellar mass function (SMF) for grouped galaxies subdivided by colour, morphology, and central/satellite. We find that spheroidal galaxies in particular dominate the bright and massive ends of the LF and SMF, respectively. More massive haloes host more massive and more luminous central galaxies. The satellites LF and SMF, respectively, show a systematic brightening of characteristic magnitude, and increase in characteristic mass, with increasing halo mass. In contrast to some previous results, the faint-end and low-mass slopes show little systematic dependence on halo mass. Semi-analytic models and simulations show similar or enhanced dependence of central mass and luminosity on halo mass. Faint and low-mass simulated satellite galaxies are remarkably independent of halo mass, but the most massive satellites are more common in more massive groups. In the first investigation of low-redshift LF and SMF evolution in group environments, we find that the red/blue ratio of galaxies in groups has increased since redshift z ≈ 0.3 relative to the field population. This observation strongly suggests that quenching of star formation in galaxies as they are accreted into galaxy groups is a significant and ongoing process.
Patterns of ‘Disorder’ During the 2019 Protests in Hong Kong: Policing, Social Identity, Intergroup Dynamics, and Radicalization
Authors: Stott Clifford , Ho Lawrence , Radburn Matt , Chan Ying Tung , Kyprianides Arabella , Morales Patricio Saavedra 
Published: September 2020

Abstract
Across the latter half of 2019, Hong Kong became the focus of world attention as it was rocked by a wave of increasingly violent confrontations between police and protesters. Both inside and outside the Territory, several powerful political actors have argued that the paramilitary-style police interventions used to manage the protests were necessary because the disorder was being fermented by agitators. In contrast, this article explores the utility of the Elaborated Social Identity Model of crowd behaviour to help explore and explain some of the social psychological dynamics through which the 2019 protests became ‘radicalised’. The article explores three key phases of their evolution to draw out the patterns of collective action and variations in policing approaches. We show that early demonstrations were focused predominantly on preventing the implementation of controversial legislation but spread and changed in form as a function of the use of crowd dispersal tactics by police. Moreover, we show how police inaction at other critical moments helped amplify perceptions of police illegitimacy that further radicalized protesters. Drawing upon a body of primary interview and secondary survey data, we also provide a social psychological analysis. We argue the observed patterns of collective action were underpinned by identity change and empowerment processes brought about as a consequence of both the structural context and the intergroup dynamics created in part by coercive policing practices.
BDNF and JNK Signaling Modulate Cortical Interneuron and Perineuronal Net Development: Implications for Schizophrenia-Linked 16p11.2 Duplication Syndrome
Authors: Willis Ashleigh , Pratt Judith A , Morris Brian J 
Published: September 2020

Abstract
Schizophrenia (SZ) is a neurodevelopmental disorder caused by the interaction of genetic and environmental risk factors. One of the strongest genetic risk variants is duplication (DUP) of chr.16p11.2. SZ is characterized by cortical gamma-amino-butyric acid (GABA)ergic interneuron dysfunction and disruption to surrounding extracellular matrix structures, perineuronal nets (PNNs). Developmental maturation of GABAergic interneurons, and also the resulting closure of the critical period of cortical plasticity, is regulated by brain-derived neurotrophic factor (BDNF), although the mechanisms involved are unknown. Here, we show that BDNF promotes GABAergic interneuron and PNN maturation through JNK signaling. In mice reproducing the 16p11.2 DUP, where the JNK upstream activator Taok2 is overexpressed, we find that JNK is overactive and there are developmental abnormalities in PNNs, which persist into adulthood. Prefrontal cortex parvalbumin (PVB) expression is reduced, while PNN intensity is increased. Additionally, we report a unique role for TAOK2 signaling in the regulation of PVB interneurons. Our work implicates TAOK2-JNK signaling in cortical interneuron and PNN development, and in the responses to BDNF. It also demonstrates that over-activation of this pathway in conditions associated with SZ risk causes long-lasting disruption in cortical interneurons.
Inhibition by Imipramine of the Voltage-Dependent K+ Channel in Rabbit Coronary Arterial Smooth Muscle Cells
Authors: An Jin Ryeol , Seo Mi Seon , Jung Hee Seok , Heo Ryeon , Kang Minji , Han Eun-Taek , Park Hongzoo , Jung Won-Kyo , Choi Il-Whan , Park Won Sun 
Published: September 2020

Abstract
Imipramine, a tricyclic antidepressant, is used in the treatment of depressive disorders. However, the effect of imipramine on vascular ion channels is unclear. Therefore, using a patch-clamp technique we examined the effect of imipramine on voltage-dependent K+ (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells. Kv channels were inhibited by imipramine in a concentration-dependent manner, with an IC50 value of 5.55 ± 1.24 µM and a Hill coefficient of 0.73 ± 0.1. Application of imipramine shifted the steady-state activation curve in the positive direction, indicating that imipramine-induced inhibition of Kv channels was mediated by influencing the voltage sensors of the channels. The recovery time constants from Kv-channel inactivation were increased in the presence of imipramine. Furthermore, the application of train pulses (of 1 or 2 Hz) progressively augmented the imipramine-induced inhibition of Kv channels, suggesting that the inhibitory effect of imipramine is use (state) dependent. The magnitude of Kv current inhibition by imipramine was similar during the first, second, and third depolarizing pulses. These results indicate that imipramine-induced inhibition of Kv channels mainly occurs in the closed state. The imipramine-mediated inhibition of Kv channels was associated with the Kv1.5 channel, not the Kv2.1 or Kv7 channel. Inhibition of Kv channels by imipramine caused vasoconstriction. From these results, we conclude that imipramine inhibits vascular Kv channels in a concentration- and use (closed-state)-dependent manner by changing their gating properties regardless of its own function.
Postcranial skeletal development of Mugil cephalus (Teleostei: Mugiliformes): morphological and life-history implications for Mugiliformes
Authors: Thieme Philipp , Vallainc Dario , Moritz Timo 
Published: September 2020

Abstract
Within the fish taxon Mugiliformes, the larval development of Mugil cephalus has been studied most intensively, because it has the widest range of distribution among all mugilids and is of interest to aquaculture all over the world. Although numerous studies have dealt with larval rearing, growth and development, the osteological development of M. cephalus and mugiliforms in general has largely been neglected. Herein, we describe the skeletal development of mullets for the first time. Cleared and double-stained specimens of aquaculture-reared M. cephalus and wild-caught mugilid larvae were examined to describe the early development of the pectoral and pelvic girdle, the vertebral column and the caudal and median fins. The description of four embryonic and six larval developmental steps within the embryonic and larval period enables us to compare larval sizes of reared and wild-caught larvae. Ontogenetic fusions of ural centra 1 and 2 into a compound centrum, in addition to the fusion of two pterygiophores in the anal fin, have implications for the perception of the adult morphology. Moreover, comparison of mugilid development with that of other ovalentarian taxa shows that recent phylogenetic hypotheses need further morphological investigation.
Adenotonsillectomy as a treatment for sleep-disordered breathing in children with ADHD
Authors: Perez Alexandra , Hunter Kimberly 
Published: September 2020

ABSTRACT
Sleep-disordered breathing (SDB) and attention deficit hyperactivity disorder (ADHD) are common disorders diagnosed in children. Although these diagnoses were previously considered unrelated, research now is showing that some symptoms of ADHD, specifically oppositional behavior, hyperactivity, and impulsivity, can be related to SDB in children and differs from bona fide ADHD. This article explores the connection between the two disorders and the importance of identifying and screening for SDB in children presenting with similar symptoms related to ADHD. The article also examines symptom improvement in patients with ADHD symptoms after an adenotonsillectomy, one of the first-line treatments for children diagnosed with SDB; this procedure may reduce the need for long-term stimulant use in some children with ADHD.
Prognostic Value of Hypochloremia in Critically Ill Patients With Decompensated Cirrhosis
Authors: Sumarsono Andrew , Wang Jiexin , Xie Luyu , Chiang Giuliana Cerro , Tielleman Thomas , Messiah Sarah E. , Singal Amit G. , Mufti Arjmand , Chen Catherine , Leveno Matthew 
Published: September 2020

Objectives:
Cirrhosis is frequently complicated by electrolyte disturbances, with prior studies primarily focused on the importance of hyponatremia. Emerging evidence on patients with chronic heart failure and chronic kidney disease has identified hypochloremia as an independent predictor for mortality. This study aimed to investigate the prognostic value of serum chloride and its association with mortality in cirrhotic patients.

Design:
Retrospective cohort study.

Setting:
The medical ICU at Parkland Memorial Hospital, a tertiary care public health system in Dallas, Texas.

Patients:
Adult patients with confirmed diagnosis of decompensated cirrhosis who were admitted to the ICU between March 2015 and March 2017.

Interventions:
None.

Measurements and Main Results:
Kaplan-Meier analysis and multivariable Cox proportional hazard ratio models were performed to determine the impact of hypochloremia on 180-day mortality. Of the 389 enrolled patients, 133 (34.2%) died within 180 days of ICU admission. Patients with hypochloremia had higher 180-day mortality than those with normochloremia (45.2% vs 26.7%; p < 0.0001). Cumulative survival via the Kaplan-Meier method was significantly lower in the hypochloremic group. Serum chloride was independently associated with 180-day mortality with multivariable adjustment (hazard ratio, 0.95; 95% CI, 0.93–0.98; p = 0.001) or after adjusting for Model for End-stage Liver Disease or Sequential Organ Failure Assessment. Contrarily, the inverse association between serum sodium and mortality no longer existed in all multivariable models.

Conclusions:
Serum chloride is independently and inversely associated with short-term mortality in critically ill cirrhotic patients. Hypochloremia, but not hyponatremia, remained associated with mortality with multivariable analyses, suggesting that hypochloremia may account for the mortality risk previously attributed to hyponatremia. These findings signify the prognostic value of serum chloride and potential inclusion of chloride into future cirrhosis prognostic scores.
Evaluation of Plasma Biomarker Utility for the Gastrointestinal Acute Radiation Syndrome in Non-human Primates after Partial Body Irradiation with Minimal Bone Marrow Sparing through Correlation with Tissue and Histological Analyses
Authors: Kumar Praveen , Wang Pengcheng , Tudor Gregory , Booth Catherine , Farese Ann M. , MacVittie Thomas J. , Kane Maureen A. 
Published: September 2020

AbstractExposure to total- and partial-body irradiation following a nuclear or radiological incident result in the potentially lethal acute radiation syndromes of the gastrointestinal and hematopoietic systems in a dose- and time-dependent manner. Radiation-induced damage to the gastrointestinal tract is observed within days to weeks post-irradiation. Our objective in this study was to evaluate plasma biomarker utility for the gastrointestinal acute radiation syndrome in non-human primates after partial body irradiation with minimal bone marrow sparing through correlation with tissue and histological analyses. Plasma and jejunum samples from non-human primates exposed to partial body irradiation of 12 Gy with bone marrow sparing of 2.5% were evaluated at various time points from day 0 to day 21 as part of a natural history study. Additionally, longitudinal plasma samples from non-human primates exposed to 10 Gy partial body irradiation with 2.5% bone marrow sparing were evaluated at timepoints out to 180 d post-irradiation. Plasma and jejunum metabolites were quantified via liquid chromatography–tandem mass spectrometry and histological analysis consisted of corrected crypt number, an established metric to assess radiation-induced gastrointestinal damage. A positive correlation of metabolite levels in jejunum and plasma was observed for citrulline, serotonin, acylcarnitine, and multiple species of phosphatidylcholines. Citrulline levels also correlated with injury and regeneration of crypts in the small intestine. These results expand the characterization of the natural history of gastrointestinal acute radiation syndrome in non-human primates exposed to partial body irradiation with minimal bone marrow sparing and also provide additional data toward the correlation of citrulline with histological endpoints.
Case Report: Suspected Donor Transmission of Acanthamoeba Keratitis After Deep Anterior Lamellar Keratoplasty
Authors: Ward Matthew S. , Bontu Sneha , Martheswaran Tanisha , Mamalis Nick , Moshirfar Majid 
Published: September 2020

Purpose:In our report, we present a suspected case of donor-derivedAcanthamoebakeratitis after deep anterior lamellar keratoplasty. To the authors' knowledge, there have been no confirmed cases ofAcanthamoebakeratitis transmission through corneal transplantation.Methods:Deep anterior lamellar keratoplasty was performed on the right eye of a 33-year-old man with severe bilateral keratoconus and an intolerance to all forms of contact lenses. The postoperative visual acuity deteriorated, while inflammation, rising ocular pressure, increasing corneal thickness, and severe eye pain began to present. Confocal imaging revealed hyperreflective cysts and trophozoite figures representative of amoebic keratitis. Despite an additional penetrating keratoplasty, antiamoeba therapy, and corneal crosslinking, the patient's condition worsened, resulting in stromal melt and corneal perforation. Emergent combined surgery of temporary keratoprosthesis, vitrectomy, lensectomy, and iridectomy was performed, along with Ahmed valve shunt placement and another penetrating keratoplasty.Results:The infection was resistant to aggressive antiamoeba therapy, but after the emergent combined surgery, the graft re-epithelialized quickly and has since remained clear, with no presence of keratitis.Conclusions:Several signs led us to believe that this case was donor-derived. There was little opportunity for graft exposure to the amoeba, and deep amoebic cysts and trophozoites were present on postoperative week 1—a highly unusual time course and depth of invasion for primary amoebic infection. In addition, pathological analysis revealed cysts only within the confines of the donor tissue and none in the recipient;Acanthamoebacysts would have been present in the recipient rim tissue if the infection originated from the patient himself.
Comprehensive Detection of Candidate Pathogens in the Lower Respiratory Tract of Pediatric Patients With Unexpected Cardiopulmonary Deterioration Using Next-Generation Sequencing
Authors: Takeuchi Suguru , Kawada Jun-ichi , Horiba Kazuhiro , Yamaguchi Makoto , Okumura Toshihiko , Suzuki Takako , Torii Yuka , Kawabe Shinji , Wada Sho , Ikeyama Takanari , Ito Yoshinori 
Published: September 2020

Objectives:
Next-generation sequencing has been applied to the investigation of microorganisms in several clinical settings. We investigated the infectious etiologies in respiratory specimens from pediatric patients with unexpected cardiopulmonary deterioration using next-generation sequencing.

Design:
Retrospective, single-center, observational study.

Setting:
Tertiary care, a children’s hospital.

Subjects:
The study enrolled a total of 16 pediatric patients with unexpected cardiopulmonary deterioration who were admitted to the PICU. Ten bronchoalveolar lavage fluid and six transtracheal aspirate samples were analyzed.

Interventions:
None.

Measurements and Main Results:
RNA libraries were prepared from specimens and analyzed using next-generation sequencing. One or more bacterial/viral pathogens were detected in the bronchoalveolar lavage fluid or transtracheal aspirate specimens from 10 patients. Bacterial and viral coinfection was considered in four cases. Compared with the conventional culture and viral antigen test results, an additional six bacterial and four viral pathogens were identified by next-generation sequencing. Conversely, among 18 pathogens identified by the conventional methods, nine pathogens were detected by next-generation sequencing. Candidate pathogens (e.g., coxsackievirus A6 and Chlamydia trachomatis) were detected by next-generation sequencing in four of 10 patients in whom no causative pathogen had been identified by conventional methods.

Conclusions:
Our results suggest that viral and bacterial infections are common triggers in unexpected cardiopulmonary deterioration in pediatric patients. Next-generation sequencing has the potential to contribute to clarification of the etiology of pediatric critical illness.
How Age Matters in the Assessment of Vertigo in the Pediatric Emergency Department
Authors: Grasso Antonio , Poropat Federico , Kamagni Vodié Theodora , Ghirardo Sergio , Barbi Egidio 
Published: September 2020

Abstract
Vertigo is a relatively frequent cause for referral to the pediatric emergency department, and it is usually caused by benign or self-limiting etiology. However, it could be difficult to evaluate especially in the younger child and could also conceal serious illness as encephalitis or cerebellitis. Our survey collected in a 10-year period 757 children assessed in pediatric emergency department for vertigo and stratified this population for etiology and for group of age: younger than 6 years (113, 14.9%), between 7 and 12 years (251, 33.2%), and older than 12 years (393, 51.9%). In addition, associated signs and symptoms, evaluation by a neurologist or an otorhinolaryngologist, and instrumental investigations were recorded.
We found that age is the most important variable to assess the possibility of a central nervous system disease as etiology cause of vertigo with a significant difference of incidence between the younger group (younger than 6 years, 23%) and older groups (3% and 1%; P < 0.001).
This finding should reinforce the index of suspicion for a central nervous system illness as cause of vertigo in the preschool children with an accurate workup including evaluation by a neurologist or an otorhinolaryngologist and instrumental investigations as needed.
Two-Year-Old With Sleep Disturbance and Left Arm Movements
Authors: Sierakowski James , Koul Pulin 
Published: September 2020

Abstract
A 29-month-old boy presented to a pediatric emergency department with complaints of trouble sleeping for more than a week. History consisted of episodes of screaming while asleep from which he could not be awakened. A detailed physical examination revealed left arm dystonia and left plantar reflex to be upgoing. Upon admission, all imaging and an electroencephalogram were normal. Extensive laboratory work was done showing positive anti-N-methyl-D-Aspartate (NMDA) antibody in the cerebrospinal fluid. Inpatient care included intravenous immunoglobulin (IVIG) and Solumedrol. Cellcept was started after definitive diagnosis and continued on discharge. The patient was discharged with residual defects that will need long-term therapy. The varied presenting symptoms are easily misinterpreted as common clinical entities. Pediatric emergency physicians need to be aware of the wide spectrum of presenting symptoms for this clinical entity because earlier diagnosis and treatment have been shown to improve long-term morbidity.
Customized Surgical Protocols for Guided Bone Regeneration Using 3D Printing Technology: A Retrospective Clinical Trial
Authors: Manzano Romero Paloma , Vellone Valentino , Maffia Francesco , Cicero Giuseppe 
Published: September 2020

Abstract
3D printing is one of the most significant technological advancements of the modern era. Among the various surgical disciplines, this new technology has shown significant improvements in the diagnosis and treatment of many diseases. The application of 3D printing has many benefits in training, preoperative planning and education.
A retrospective study was conducted at the European University of Madrid (UEM). Patients were selected in this study using the following inclusion criteria: age over 18 years old, a preoperative cone beam computed tomography (CBCT), patients with moderate or severe vertical or horizontal defects, presence or absence of the tooth in the area to regenerate, no bone regeneration surgery before. Bone defects were measured: in the CBCT using White Fox Imaging, on the 3D printed model and then intraoperatively from the area to be regenerated. The average of the bone defects on the 3D measurements was statistically compared with the average of the bone defect measurements in the patient's mouth to evaluate the model reliability.
The mean age of the patients was 53,07 years old, with a range from 45 to 63. Females were more affected than males, with a ratio of 12/13 (92%). The most frequent side affected was maxilla 10/13 (77%) and the most type of defect reported was horizontal 10/13 (77%). The means in width (x = 8,2923) and height (x = 6,9615) of the 3D model, were close and clinically acceptable if compared with the means obtained from the measurements in width (x = 7,9230) and height (x = 6,8076) of the patients’ bone defects. None of the patients underwent further surgeries or needed intraoperative surgical corrections obtaining reliable results in terms of presurgical planning.
It is possible to affirm that the use of 3D printed models can be a crucial complement when planning guided bone regeneration procedures, due to high reliability, and representing a turning point in many aspects of oral surgery.