bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of enhancement in paretic shoulder kinematics after stroke with musical cueing
Authors: Kang Shinil , Shin Joon-Ho , Kim In Young , Lee Jongshill , Lee Ji-Yeoung , Jeong Eunju 
Published: October 2020

AbstractMusical cueing has been widely utilised in post-stroke motor rehabilitation; however, the kinematic evidence on the effects of musical cueing is sparse. Further, the element-specific effects of musical cueing on upper-limb movements have rarely been investigated. This study aimed to kinematically quantify the effects of no auditory, rhythmic auditory, and melodic auditory cueing on shoulder abduction, holding, and adduction in patients who had experienced hemiparetic stroke. Kinematic data were obtained using inertial measurement units embedded in wearable bands. During the holding phase, melodic auditory cueing significantly increased the minimum Euler angle and decreased the range of motion compared with the other types of cueing. Further, the root mean square error in the angle measurements was significantly smaller and the duration of movement execution was significantly shorter during the holding phase when melodic auditory cueing was provided than when the other types of cueing were used. These findings indicated the important role of melodic auditory cueing for enhancing movement positioning, variability, and endurance. This study provides the first kinematic evidence on the effects of melodic auditory cueing on kinematic enhancement, thus suggesting the potential use of pitch-related elements in psychomotor rehabilitation.
Patterns of ties in problem-solving networks and their dynamic properties
Authors: Braha Dan 
Published: October 2020

AbstractUnderstanding the functions carried out by network subgraphs is important to revealing the organizing principles of diverse complex networks. Here, we study this question in the context of collaborative problem-solving, which is central to a variety of domains from engineering and medicine to economics and social planning. We analyze the frequency of all three- and four-node subgraphs in diverse real problem-solving networks. The results reveal a strong association between a dynamic property of network subgraphs—synchronizability—and the frequency and significance of these subgraphs in problem-solving networks. In particular, we show that highly-synchronizable subgraphs are overrepresented in the networks, while poorly-synchronizable subgraphs are underrepresented, suggesting that dynamical properties affect their prevalence, and thus the global structure of networks. We propose the possibility that selective pressures that favor more synchronizable subgraphs could account for their abundance in problem-solving networks. The empirical results also show that unrelated problem-solving networks display very similar local network structure, implying that network subgraphs could represent organizational routines that enable better coordination and control of problem-solving activities. The findings could also have potential implications in understanding the functionality of network subgraphs in other information-processing networks, including biological and social networks.
Dual-incision minimally invasive fasciotomy of the anterior and peroneal compartments for chronic exertional compartment syndrome of the lower leg
Authors: Grechenig Christoph , Valsamis Epaminondas Markos , Koutp Amir , Hohenberger Gloria , di Vora Theresa , Grechenig Peter 
Published: October 2020

AbstractTo evaluate the risk of iatrogenic injury when using a dual-incision minimally invasive technique to decompress the anterior and peroneal compartments of the lower leg. Forty lower extremities from 20 adult cadavers, embalmed with Thiel’s method, were subject to fasciotomy of the anterior and peroneal compartment using a dual-incision minimally invasive fasciotomy. The first incision was made 12 cm proximal to the lateral malleolus to identify and protect the superficial peroneal nerve (SPN). The second incision was made at the mid-point of the Fibula (half-way between the fibular head and the lateral malleolus). Release of the anterior and peroneal compartments was successful in all specimens. Two nerve injuries of the superficial peroneal nerve were reported. More precisely, in these cases the medial dorsal cutaneous nerve got injured during the fascial opening of the extensor compartment. Two incision minimally invasive fasciotomy to decompress the anterior and peroneal compartments of the lower leg appears to be safe with regard to the results of this study.
Radon concentration in conventional and new energy efficient multi-storey apartment houses: results of survey in four Russian cities
Authors: Yarmoshenko Ilia V. , Onishchenko Aleksandra D. , Malinovsky Georgy P. , Vasilyev Aleksey V. , Nazarov Evgeniy I. , Zhukovsky Michael V. 
Published: October 2020

AbstractDuring last decades, energy saving in new buildings became relevant within the energy efficiency strategies in various countries. Such energy efficient building characteristics as air tightening and low ventilation can compromise indoor air quality, in particular, increase radon concentration. In Russia, a significant part of the new buildings is the energy efficient multi-storey apartment houses. The aim of this study is to assess the significance of possible radon concentration increase in new energy efficient buildings in comparison with typical conventional multi-storey houses of previous periods. Radon surveys were conducted in Russian cities Ekaterinburg, Chelyabinsk, Saint-Petersburg and Krasnodar. The radon measurements were carried out in 478 flats using CR-39 nuclear track detectors. Energy efficiency index (EEI) was assigned to each house. All buildings were divided into six main categories. The smallest average radon concentration was observed in panel and brick houses built according to standard projects of 1970–1990 (four-city average 21 Bq/m3). The highest average radon concentration and EEI were observed in new energy efficient buildings (49 Bq/m3). The trend of radon increase in buildings ranked with high EEI index is observed in all cities. The potential increase of radiation exposure in energy-efficient buildings should be analyzed taking into account the principles of radiological protection.
Assessing the susceptibility of schools to flood events in Iran
Authors: Yousefi Saleh , Pourghasemi Hamid Reza , Emami Sayed Naeim , Rahmati Omid , Tavangar Shahla , Pouyan Soheila , Tiefenbacher John P. , Shamsoddini Shahbaz , Nekoeimehr Mohammad 
Published: October 2020

AbstractCatastrophic floods cause deaths, injuries, and property damages in communities around the world. The losses can be worse among those who are more vulnerable to exposure and this can be enhanced by communities’ vulnerabilities. People in undeveloped and developing countries, like Iran, are more vulnerable and may be more exposed to flood hazards. In this study we investigate the vulnerabilities of 1622 schools to flood hazard in Chaharmahal and Bakhtiari Province, Iran. We used four machine learning models to produce flood susceptibility maps. The analytic hierarchy process method was enhanced with distance from schools to create a school-focused flood-risk map. The results indicate that 492 rural schools and 147 urban schools are in very high-risk locations. Furthermore, 54% of rural students and 8% of urban students study schools in locations of very high flood risk. The situation should be examined very closely and mitigating actions are urgently needed.
Efficacy of Balneotherapy and Mud Therapy in Patients with Knee
Osteoarthritis: A Systematic Literature Review
Authors: Raza Hafiz Muhammad Asim , Krutulyte Grazina , Rimdeikiene Inesa , Savickas Raimondas 
Published: October 2020

Abstract
Objectives To identify literature reporting on thermal mineral water and
mud therapy effectiveness on pain, stiffness and knee function in patients with
knee osteoarthritis.
Design Systematic evidence scan of MEDLINE and PubMed was performed to
identify the randomized controlled trial studies published from 2004 to December
2018.
Study selection Papers reporting the effect of balneotherapy and mud
therapy for treating knee OA, a duration of ≥2 weeks and in which
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores
were used as an outcome measure.
Data extraction Not RCT, Studies not in English.
Results A quantitative meta-analysis of ten studies (831 patients) was
performed. Five clinical studies (407 patients) measured effectiveness of
balneotherapy and there was significant difference between the groups in WOMAC
pain score, WOMAC stiffness score and WOMAC function score, with the differences
in favour of balneotherapy. Six clinical studies (500 patients) measured
effectiveness of mud therapy and there was significant difference between the
groups in WOMAC pain score, WOMAC stiffness score and WOMAC function score, with
the differences in favour of mud therapy.
Conclusion This meta-analysis indicates that balneotherapy and mud
therapy were clinically effective in relieving pain, stiffness, and improving
function, as assessed by WOMAC score.
Results of liver and spleen endoscopic ultrasonographic elastography predict portal hypertension secondary to chronic liver disease
Authors: Robles-Medranda Carlos , Oleas Roberto , Puga-Tejada Miguel , Valero Manuel , Valle Raquel Del , Ospina Jesenia , Pitanga-Lukashok Hannah 
Published: October 2020

AbstractBackground and study aims Assessment of endoscopic ultrasonography (EUS)-elastography of the liver and spleen may identify patients with portal hypertension secondary to chronic liver disease. We aimed to evaluate use of EUS-elastography of the liver and spleen in identification of portal hypertension in patients with chronic liver disease.Patients and methods This was a single-center, diagnostic cohort study. Consecutive patients with liver cirrhosis and portal hypertension underwent EUS-elastography of the liver and spleen. Patients without a history of liver disease were enrolled as controls. The primary outcome was diagnostic yield of liver and spleen stiffness measurement via EUS-elastography in prediction of portal hypertension secondary to chronic liver cirrhosis. Cutoff values were defined through Youden’s index. Overall accuracy was calculated for parameters with an area under the receiver operating characteristic (AUROC) curve ≥ 80 %.Results Among the 61 patients included, 32 had cirrhosis of the liver. Liver and spleen stiffness was measured by the strain ratio and strain histogram, with sensitivity/(1 − specificity) AUROC values ≥ 80 %. For identification of patients with cirrhosis and portal hypertension, the liver strain ratio (SR) had a sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 84.3 %, 82.8 %, 84.4 %, and 82.8 %, respectively; the liver strain histogram (SH) had values of 87.5 %, 69.0 %, 75.7 %, and 83.3 %, respectively. EUS elastography of the spleen via the SR reached a sensitivity, specificity, PPV, and NPV of 87.5 %, 69.0 %, 75.7 %, and 83.3 %, respectively, whereas the values of SH were 56.3 %, 89.7 %, 85.7 %, and 65.0 %, respectively.Conclusion Endoscopic ultrasonographic elastography of the liver and spleen is useful for diagnosis of portal hypertension in patients with cirrhosis.
Vorhofflimmern und Antikoagulation im Alter
Authors: Darius Harald 
Published: October 2020

ZusammenfassungVorhofflimmern und auch Vorhofflattern sind aufgrund der mechanischen Stase im Vorhof mit einer hohen Thrombembolierate, also Schlaganfällen oder systemischen Thrombembolien, assoziiert. Die orale Antikoagulation reduziert die Rate der thrombembolischen Ereignisse um ca. ⅔, bei Einsatz von NOAC sogar noch etwas mehr. Bei älteren und alten Patienten ist das thrombembolische Risiko deutlich erhöht, insbesondere wenn Risikofaktoren wie arterielle Hypertonie, Herzinsuffizienz oder Niereninsuffizienz vorhanden sind. Ältere und alte Patienten profitieren von einer Antikoagulation aufgrund des höheren absoluten Risikos deutlich mehr als jüngere Patienten, obwohl sie auch ein erhöhtes Blutungsrisiko haben. Das Blutungsrisiko kann durch Behandlung modifizierbarer Risikofaktoren, Überprüfung bzw. Modifikation der Komedikation und patientenorientierte Dosierung der NOAC unter Berücksichtigung der Nierenfunktion deutlich reduziert werden. Dadurch können auch ältere und alte Patienten von einer effektiven Antikoagulation profitieren und Schlaganfälle verhindert werden.
Safety and efficacy of lumen-apposing metal stents versus plastic stents to treat walled-off pancreatic necrosis: systematic review and meta-analysis
Authors: Chandrasekhara Vinay , Barthet Marc , Devière Jacques , Bazerbachi Fateh , Lakhtakia Sundeep , Easler Jeffrey J. , Peetermans Joyce A. , McMullen Edmund , Gjata Ornela , Gourlay Margaret L. , Abu Dayyeh Barham K. 
Published: October 2020

Abstract
Background and study aims Lumen-apposing metal stents (LAMS) are increasingly used for drainage of walled-off pancreatic necrosis (WON). Recent studies suggested greater adverse event (AE) rates with LAMS for WON. We conducted a systematic review and meta-analysis to compare the safety and efficacy of LAMS with double-pigtail plastic stents (DPPS) for endoscopic drainage of WON. The primary aim was to evaluate stent-related AEs.
Methods In October 2019, we searched the Ovid (Embase, MEDLINE, Cochrane) and Scopus databases for studies assessing a specific LAMS or DPPS for WON drainage conducted under EUS guidance. Safety outcomes were AE rates of bleeding, stent migration, perforation, and stent occlusion. Efficacy outcomes were WON resolution and number of procedures needed to achieve resolution. A subanalysis including non-EUS-guided cases was performed.
Results Thirty studies including one randomized controlled trial (total 1,524 patients) were analyzed. LAMS were associated with similar bleeding (2.5 % vs. 4.6 %, P = 0.39) and perforation risk (0.5 % vs. 1.1 %, P = 0.35) compared to DPPS. WON resolution (87.4 % vs. 87.5 %, P = 0.99), number of procedures to achieve resolution (2.09 vs. 1.88, P = 0.72), stent migration (5.9 % vs. 6.8 %, P = 0.79), and stent occlusion (3.8 % vs. 5.2 %, P = 0.78) were similar for both groups. Inclusion of non-EUS-guided cases led to significantly higher DPPS bleeding and perforation rates.
Conclusions LAMS and DPPS were associated with similar rates of AEs and WON resolution when limiting analysis to EUS-guided cases. Higher bleeding rates were seen in historical studies of DPPS without EUS guidance. Additional high-quality studies of WON treatment using consistent outcome definitions are needed.
Proposal of a Multivariable Prediction Model for Graded Morbidity after Liver Resection for Colorectal Metastases
Authors: Sneidere Mara , Schrem Harald Heinrich , Mahlmann Jan Christoph , Beetz Oliver , Cammann Sebastian , Oldhafer Felix , Kleine Moritz , Klempnauer Juergen , Kaltenborn Alexander , Zwirner Ulrich , Kulik Ulf 
Published: October 2020

Abstract
Background Prognostic models to predict individual early postoperative morbidity after liver resection for colorectal liver metastases (CLM) are not available but could enable
optimized preoperative patient selection and postoperative surveillance for patients at greater risk of complications. The aim of this study was to establish a prognostic model for the
prediction of morbidity after liver resection graded according to Dindo.
Methods N = 679 cases of primary liver resection for CLM were retrospectively analyzed using univariable and multivariable ordinal regression analyses. Receiver operating
characteristics curve (ROC) analysis was utilised to assess the sensitivity and specificity of predictions and their potential usefulness as prognostic models. Internal validation of the
score was performed using data derived from 129 patients.
Results The final multivariable regression model revealed lower preoperative levels, a greater number of units of intraoperatively transfused packed red blood cells (pRBCs), longer
duration of surgery, and larger metastases to independently influence postoperatively graded morbidity. ROC curve analysis demonstrated that the multivariable regression model is able to
predict each individual grade of postoperative morbidity with high sensitivity and specificity. The areas under the receiver operating curves (AUROC) for all of these predictions of
individual grades of morbidity were > 0.700, indicating potential usefulness as a predictive model. Moreover, a consistent concordance in Grades I, II, IV, and V according to the
classification proposed by Dindo et al. was observed in the internal validation.
Conclusion This study proposes a prognostic model for the prediction of each grade of postoperative morbidity after liver resection for CLM with high sensitivity and specificity
using pre- and intraoperatively available variables.
Novel risk factors for recurrent biliary obstruction and pancreatitis after metallic stent placement in pancreatic cancer
Authors: Takeda Tsuyoshi , Sasaki Takashi , Mie Takafumi , Furukawa Takaaki , Kanata Ryo , Kasuga Akiyoshi , Matsuyama Masato , Ozaka Masato , Sasahira Naoki 
Published: October 2020

Abstract
Background and study aims Self-expandable metallic stents (SEMS) are now widely used even for patients with borderline resectable (BR) pancreatic cancer (PC), as neoadjuvant therapy has become common. Therefore, we conducted this study to evaluate safety of SEMS placement in the population including BR PC and to explore risk factors for recurrent biliary obstruction (RBO), pancreatitis, and cholecystitis.
Patients and methods We retrospectively investigated consecutive patients with PC who received initial SEMS between January 2015 and March 2019. We compared time to RBO (TRBO), causes of RBO, and stent-related adverse events (AEs) according to resectability status. Univariate and multivariate analyses were performed to explore risk factors for TRBO, pancreatitis, and cholecystitis.
Results A total of 135 patients were included (BR 31 and unresectable [UR] 104). Stent-related AEs occurred in 39 patients: pancreatitis 14 (mild/moderate/severe 1/6/7), cholecystitis 12, and non-occluding cholangitis 13. TRBO, causes of RBO, and stent-related AEs were not significantly different according to resectability status. Overall rate of RBO was higher in UR PC due to the longer follow-up period. Sharp common bile duct (CBD) angulation was an independent risk factor for short duration of TRBO. High pancreatic volume index and SEMS of high axial force were independent risk factors for pancreatitis, whereas tumor involvement to orifice of cystic duct was the only risk factor for cholecystitis.
Conclusions We demonstrated that SEMS can be safely deployed even in patients with BR PC. Sharp CBD angulation and high pancreatic volume index were identified as novel risk factors for RBO and pancreatitis, respectively, after SEMS placement.
Duodenal mucosal resurfacing: Multicenter experience implementing a minimally invasive endoscopic procedure for treatment of type 2 diabetes mellitus
Authors: van Baar Annieke C.G. , Haidry Rehan , Rodriguez Grunert Leonardo , Galvao Manoel P. Neto , Bisschops Raf , Hayee Bu Hussain , Costamagna Guido , Deviere Jacques , Bergman Jacques J.G.H.M. 
Published: October 2020

Abstract
Background and study aims Duodenal mucosal resurfacing (DMR) is an endoscopic procedure which improves insulin resistant metabolic disease, including type 2 diabetes mellitus (T2DM). The aim of this report was to evaluate the feasibility and procedural aspects of DMR and to provide more specific DMR procedural guidance for endoscopists.
Patients and methods In this international multicenter, prospective, open-label study, patients on oral anti-diabetic agents for treating T2DM underwent single DMR. DMR entails circumferential submucosal lifting followed by circumferential mucosal hydrothermal ablation using an over-the-guidewire balloon catheter for lifting and ablation. For the first 28 patients a dual catheter system was used. During the study, a new integrated catheter was developed which was used for the latter 18 patients. During DMR, procedure success (complete DMR: duodenal ablation length ≥ 9 cm) and procedure duration were captured.
Results Forty-six patients underwent DMR. Using the dual catheter system, a complete DMR was performed in 22 of 28 patients (79 %). In the next eighteen patients who underwent DMR with the integrated catheter, a complete DMR was performed in 15 of 18 patients (83 %). The integrated catheter facilitated the DMR procedure and resulted in a reduction in procedure time. A detailed table and video are provided for future endoscopists.
Conclusions In our multicenter study, DMR was found to be feasible in the hands of experienced endoscopists. The integrated DMR catheter was a welcome modification during the study, allowing for easier ablation administration. Further optimization of the technique would be valuable prior to widespread dissemination.
Peroral endoscopic myotomy (POEM) is more cost-effective than laparoscopic Heller myotomy in the short term for achalasia: economic evaluation from a randomized controlled trial
Authors: Conte Tatiana Morgado , Haddad Luciana Bertocco de Paiva , Ribeiro Igor Braga , de Moura Eduardo Turiani Hourneaux , DʼAlbuquerque Luiz Augusto Carneiro , de Moura Eduardo Guimarães Hourneaux 
Published: October 2020

Abstract
Background and study aims We aimed to perform an economic evaluation of peroral endoscopic myotomy (POEM) and laparoscopic Heller myotomy (LHM) for the treatment of achalasia.
Materials and methods An economic cost-utility analysis was carried out over a time horizon of 1 year. Patients with achalasia who were admitted to the gastroenterology outpatient clinic of a public tertiary referral hospital were assigned to undergo POEM or LHM. The monetary amounts ​​were extracted from the intranet of the institution using microcosting. All costs associated with the procedure, hospitalization, clinical follow-up and resolution of therapeutic complications were included. The utility data were measured in quality-adjusted life years (QALYs), which were estimated from the scores of a quality-of-life questionnaire.
Results Forty patients (20 POEM patients and 20 LHM patients) were included. The final cost associated with POEM and LHM was US$ 2,619.19 ± 399.53 and US$ 1,696.44 ± 412.21, respectively (P < 0.001). However, the QALYs in the POEM group (0.434 ± 0.215 vs 0.332 ± 0.222, P = 0.397) were slightly higher than those in the LHM group. The incremental cost-utility ratio (ICUR) suggested that an additional US$ 9,046.41/QALY gained was required when using POEM.
Conclusion For the treatment of achalasia in the public health system, POEM appears to be more cost-effective than LHM in the short term.