bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and Prevalence of Crohn’s Disease and Ulerative Colitis (2013–2017) Based on the Latvian Nationwide Medicines Reimbursement Database
Authors: Mirzajanova Irēna , Purviņa Santa , Pokrotnieks Juris 
Published: May 2020

Abstract
Inflammatory bowel disease (IBD) is a chronic, relapsing–remitting, inflammatory condition of the gastrointestinal tract which consists of Crohn’s disease (CD), ulcerative colitis (UC) and undifferentiated IBD. Epidemiology of IBD is changing worldwide, but a significant gap remains in the description of the IBD population in Latvia. The aim of the study was to determine the incidence and prevalence rates of IBD in Latvia in the period between 2013 and 2017. Retrospective analysis of reimbursed medicines claims for IBD diagnoses from the Latvian National Health Service database (NHS) was conducted for the period of 2012 to 2017. From CD patients, 53.7% were female and the area of residency strongly favoured urban areas vs rural districts of Latvia, 59.1% vs 40.9%, respectively. A similar demographic pattern was observed in UC patients, where 56.2% were female and 55.1% of the total UC population lived in urban areas. The overall age- and sex-adjusted incidence rates for CD and UC were 16.45 (CI95% [14.68, 18.21]) and 70.53 (CI95% [66.88, 74.19]) per 100 000 population, respectively, for the entire 2013–2017 period. The prevalence of CD and UC in 2012 was 12.4 and 54.8 cases per 100 000 persons, respectively, compared to 15.5 and 79.5 cases per 100 000 persons in CD and UC in 2017, resulting in a 25% increase in prevalence of CD and 41% increase in UC over the 5-year period. For the first time temporal trends in IBD incidence and prevalence as well as differences across age groups and gender over a five-year period are reported for Latvia.
The Urban Geoheritage of Clermont-Ferrand: From Inventory to Management
Authors: Vereb Viktor , van Wyk de Vries Benjamin , Guilbaud Marie-Noëlle , Karátson Dávid 
Published: May 2020

Abstract
In sprawling urban areas, geoheritage is suppressed into limited niches. Potential geosites are highly vulnerable and could disappear completely during construction, or their integrity could be irreversibly modified. Here, we create an inventory of urban geoheritage for Clermont-Ferrand in France, recording more than 50 sites using the French national workflow. The results of the quantitative assessment have been used to differentiate between geosites (high scientific value) and geodiversity sites (limited scientific significance, important additional values). Finally, we discuss some important considerations on urban geoconservation, such as geotouristic itineraries or customized management strategies for each site and the whole city.
10. Comparative Interpretative Analysis of David Mancini’s Work Suite for Solo Drumset and Percussion Ensemble
Authors: Stavrat Constantin 
Published: May 2020

Abstract
The endless possibilities of expression that jazz has developed over the last hundreds of years could not only influence the composers, but also the performers who dedicated themselves to the fascinating and complex field of percussion. One of the percussion players who has been influenced by this genre is David Mancini, whose conposition I chose for comparative analysis -
Suite for solo drum and percussion ensemble
in the interpretation of two percussion ensembles Vibraslap and Guiro, whose activity was perpetuated due to enthusiasm and the professionalism of the two mentors of the respective groups, professors Marian Vaida and Bedo Gabor, both perfected within the percussion class of the Conservatory of Music “George Enescu” in Iasi Romania, founded and led for more than half a century by the renowned professor Florian Simion. Two totally different interpretations of David Mancini’s work -
Suite for solo drums and percussion ensemble
, each with a few moments of success, but also with the need to perfect many elements of technique and interpretive design.
14. Nicolette Choral Piece by Maurice Ravel. Analysis and Interpretative Concept
Authors: Burduloi Marta Otilia 
Published: May 2020

Abstract
In order to place the piece in the context of the impressionist current, we will try to emphasize its characteristics and tendencies on several occasions. The unit of romantic art, governed by academic laws, begins to be shaken, realism as a fundamental direction, based on a direct connection with life, gradually imposing itself, bringing a new aesthetic, with its own, particular ideas, with specific methods and means of expression. The decline of Romanticism started with the first signs of crisis manifested by the repetition of the clichés and by the insistence with which one struggles to maintain all the arts within the narrow frame of the canons, is accentuated and, especially after the Paris Commune, will lead to the outline of new directions, of national specificity, to which a large number of artists from all generations joined, considering their action as a mission and a patriotic duty of honor, of an exceptional significance in finding a path conducive to the further development of French art.
4. The Place of Visual Art in the Development of Critical Dimensions of Thinking
Authors: Assante Gabriela Monica 
Published: May 2020

Abstract
The present study aims to describe the ways in which art education impacts community life through art products. The sample consists of 32 teachers/creators in various fields of work such as fine arts, composition, literature, musical interpretation, choreography and acting. Categorical content analysis is used for data analysis. The highest-ranking emerging theme is related to the means of educational intervention in the community through art. Artistic education leads to empowerment and emancipation by provoking people to think differently while the exposure to artistic creations has a therapeutic effect and contributes to identifying new ways of action. Artists in the role of teachers feel a responsibility both for the educational process and also for the emotional message that their creative product transmits to the audience.
5. Quality Aspects of Product Design in Artistic Education
Authors: Bajçinovci Bard , Bajçinovci Uliks , Rexha Elena , Bajçinovci Bujar 
Published: May 2020

Abstract
The University of Prishtina “Hasan Prishtina” is the biggest higher education institution in Kosovo, which ever since its foundation has held the main burden of education and the development of the Kosovar society. If in the past the University of Prishtina was not only a hearth of knowledge, but also an icon of Kosova’s high education, now its mission is to offer stable and qualitative education to the new generation, functioning as an asset for the development and the strengthening of the Kosovar society. Currently, the UP is the biggest higher education institution in the Kosovo, with 42.006 students, above 1.000 academic staff members and around 350 administrative staff members, accommodated in 14 Academic Units. The research conducted in this paper reflects quality aspects in artistic education for sustainable product design, especially in art, architecture, creativity and innovation in academia curricula. The research methods consist of empirical observation in academia, direct observation of teaching methods, and promoting contemporary interactive teaching methods. To perceive a clearer research data, exploring was made within: The department of Architecture, Department of Anthropology-Archeology, The faculty of Arts in the University of Prishtina, also with UBT - Higher Education Institution in Kosovo, in the context of the possibilities for the improvement of the curricula’s, within actual and accredited academic frameworks. Research concludes that new teaching strategies must involve a new closeness, a brand new and more refining holistic system, as a response to less functional academic curriculums.
7. The Burke’s Pentad Heuristic: Potentiality for Creative Idea Generation in Graphic Communication Design
Authors: Ebigbagha Sylvester Zifegha 
Published: May 2020

Abstract
The Burke’s Pentad (Act, Agent, Agency, Scene and Purpose) is a creative idea generation guide for dramatism (or dramatistic framework). Its utilization to probe, often engenders a process of stochastic combination, whereby a vista of multiple ideational variations emerge in one’s mind, from which an appropriate subset could be selected and implemented. This usually affords inspiration, creative flow and energy that are pivotal for success in drama as much as in visual communication. However, there is prevalent unawareness of the potentials of the Pentad model as a veritable structure to creating innovative ideas in art and design. Therefore, this paper focused on the potentiality of the Pentad for creating and or analyzing ideas on form generation for pedagogical, practical, or theoretical purpose in graphic communication design. Towards this end, a triangulation of methods: critical-historical-analytic examination, artistic exploration, and content analysis are employed. The paper introduced the reader to the need for a strategy to generate new ideas, stimulate creative thinking, and enhance self-motivation in visual expression for structural and human development. Furthermore, it highlighted the processes of creativity, and form generation for material culture development. Also, the paper discussed the Pentad and its utilization for generating new ideas in art/design. It was found that the Pentad is indispensable in generating ideas for creating, interpreting and teaching visual form. The paper ended with the need for visual communicators to be acquainted by use of the Pentad for creative ideas to generate product with satisfactory outcomes.
6. Early Musical Education as a Premise for the Development of the Child’s Upright Personality
Authors: Cosumov Marina 
Published: May 2020

Abstract
A person upright development is essentially connected to communication, and music is the language with the highest degree of communication, is the purest and deepest language, able to express the hidden, the essential, the spiritual. Musical education, achieved in all forms, contexts, periods, etc. under the mark of the upright development of human personality, means “wisdom, balance, love, inner light, harmony, “feeling”, etc.”. [I. Gagim]. Childhood, for this purpose, remains the fundamental stage for the subsequent development and initiation of the child in the “real” world, constituting at the same time, the foundation for his/her human “ becoming”.
8. Training of Artistic Skills of the Music Teacher
Authors: Morari Marina 
Published: May 2020

Abstract
Human capital represents for Moldova the basic resource for long-term development. The quality of human resources is largely ensured by the education system. The lack of a systemic approach to changes in education is identified in the National Development Strategy “Moldova 2030” as a causal factor in guaranteeing quality education for all. Artificial separation of training (teaching of academic content) from education is still ongoing. In the context of sustainable development, current topics are taught rather mechanically than practiced. Extensively new and often optional curricula are added, instead of integrating these topics into core disciplines and used as a basis for reviewing barriers between disciplines and applied strategies, so that they become more interactive and more targeted. towards the development of transversal competences.
There are imperative models / projects of education oriented towards the attainment of the transdisciplinary and transversal competences, oriented towards a graduate endowed with transdisciplinary competences, formed through the prism of all the studied school disciplines and that allow him the active participation in the social and economic life. Promoting curricular approaches through one-day cross-disciplinary activities (recommended in the national curriculum) requires the extension of the competence of the teachers in the field of interdisciplinary learning. Required: collaborative planning (between teachers from different disciplines / curricular areas / domains), models of educational approach that use Science, Technology, Engineering, Arts and Mathematics (STEAM) as access points for guidance in the learning process, in the context of real life, through transdisciplinarity.
In the article are: (a) described the practices of integrating the arts in STEAM education in the USA, (b) identified the prospects for integrating the school disciplines in the curricular arts area into the STEAM education in the primary education level in the Republic of Moldova. STEAM education is an innovative initiative in learning, which supports the development and practice of the skills of students and young people of the century. XXI, considered one of the main trends in world education, practiced in the US and over 10 countries in the EU. The integration of STEAM education models into the Moldovan education system (starting with early education and primary education) can contribute to the effective implementation of educational policies through the regulatory function (targeted by the teleological component) and the strategic function targeted by the content and process components.
12. The Purpose of Empathy Formation and its Role in the Development of Modern Teachers from Primary Classes
Authors: Postolache Iulia 
Published: May 2020

Abstract
The development of empathy is directly depended on the possibility of knowing the roles, establishing relationships, feeling emotions in different social situations. The functions of empathy allow an effective communication between teachers and students, strengthening mutual trust by analyzing their actions in the process of discussion. However, all these noted, can be achieved in the process of communication between the speaker and the listener, the teacher and the student. Empathy is characteristic to teachers who are able to think about their friend, not to be selfish. Empathetic teachers can feel what others feel, identify their emotions, help others to solve problems and imagine themselves in someone’s situation. Empathetic teachers try to be in somebody’s coat and realize what students would feel in certain situations. Empathy can be felt all the time and it’s necessary to modern people, because everybody needs to accept himself and to respect others.
Are “fair” wages quantitatively important for business cycle fluctuations in Bulgaria?
Authors: Vasilev Aleksandar 
Published: May 2020

Abstract
We introduce “fair” wages in a general-equilibrium model where worker’s effort is unobservable and investigate whether such a mechanism can quantitatively account for the degree of real wage rigidity in the Bulgarian labor markets, as documented in Lozev, Vladova, and Paskaleva (2011) and Paskaleva (2016). In contrast to Danthine and Kurmann (2004), we internalize the effect that past wages have on the current effort level. We calibrate the model to Bulgarian data (1999-2016), and quantify the effect of technological shocks on hours and wages in the theoretical setup. Overall, the calibrated model with “fair” wages performs poorly when it comes to the relative volatilities of labor market variables. This is because aggregate labor market conditions, as proxied by the employment rate and past aggregate wages, turn out not to be quantitatively important for business cycles in Bulgaria.
The clinical impacts of early using glutamine/arginine enriched high protein density formula at trophic dose in intolerant enteral nutrition cachectic hypoalbuminemic hospitalized patients
Authors: Al-Shebli Hussien , Al-Shayyab Sameer , Younes Moh’d Nour Bani , Badwan Sinan , Obeidat Mohammed , Alshawabkeh Amani , Almanaseer Areej , Fannoun Razan 
Published: May 2020

Abstract

Background. We sought to evaluate the clinical impacts of the early administration of trophic doses of a glutamine/arginine enriched enteral nutrition formula (ENF) with a high protein density to cachectic hypoalbuminemic hospitalized patients intolerant to enteral nutrition.

Methods. A retrospective analysis was conducted using the nutritional and non-nutritional data of patients admitted to our institution from April 2017 through August 2019. Patients who died or were discharged before completing ≥1 weeks of hospital admission, or those whose data could not be obtained were excluded. Among other variables, percent changes in serum albumin levels (%∆ALB), C – reactive protein (CRP) and their ratios were expressed as Mean ± SD using the Independent Samples T-test, while categorical variables were expressed as numbers with percentages by using χ2 test. Two tested groups were determined based on the use of ENF: Group I received trophic doses of ENF, while Group II received no enteral nutrition.

Results. The overall hospital length of stay (LOS) and overall 28-day hospital mortality were significantly lower in Group I when compared with Group II with Means ± SDs of (11.32 ± 2.19 days vs 23.49 ± 4.33 days) and (13.13% vs. 28.16%), respectively. Also, significantly higher (%∆ALB) for Group I compared with group II (43.48% ± 7.89% vs. 33.45% ± 6.18%), respectively was observed.

Conclusion. In malnourished hypoalbuminemic patients suffering from feeding intolerance, early trophic administration of glutamine/arginine enriched high protein density ENF was well tolerated and may be associated with increased plasma albumin levels, reduced LOS, and overall 28-day mortality, and hence may be considered in such patients.
Hydrocarbon-Generating Potential of Eocene Source Rocks in the Abakaliki Fold Belt, Nigeria / Potencial za nastanek oglikovodikov v eocenskih izvornih kamninah nariva Abakaliki
Authors: Oluwajana O.A. , Opatola A.O. , Ogbe O.B. , Johnson T.D. 
Published: May 2020

Abstract
Subsurface information on source rock potential of the Eocene shale unit of the Abakaliki Fold Belt is limited and has not been widely discussed. The total organic carbon (TOC) content and results of rock-eval pyrolysis for nine shale samples, as well as the one-dimensional (1D) geochemical model, from an exploration well in the Abakaliki Fold Belt were used to evaluate the source rock potentials and timing of hydrocarbon generation of Lower Eocene source rocks. The TOC content values of all the samples exceeded the minimum threshold value of 0.5 wt.% required for potential source rocks. A pseudo-Van Krevelen plot for the shale samples indicated Type II–III organic matter capable of generating gaseous hydrocarbon at thermally mature subsurface levels. The 1D burial model suggests that the Eocene source rock is capable of generating oil and gas at the present time. The modelled transformation ratio trend indicates that a fair amount of hydrocarbon has been expelled from the source rocks. The results of this study indicate that the Eocene source units may have charged the overlying thin Eocene sand bodies of the Abakaliki Fold Belt.
Cardiotoxicity - the first cause of morbidity and mortality in pediatric patients survivors of acute lymphoblastic leukemia
Authors: Radu Letitia Elena , Sfetea Roxana Corina , Arion Constantin Virgiliu , Colita Anca 
Published: May 2020

Abstract
Acute lymphoblastic leukemia is the most common hematological malignancy at pediatric age. Cardiotoxicity holds the first place among the causes of morbidity and mortality in these patients. Anthracyclines are cytostatic drugs frequently associated with cardiotoxicity. Early diagnosis of cardiac impairment during the treatment of pediatric patients is extremely important, both for modulating future chemotherapy and for administering cardioprotective agents. Long term monitoring after chemotherapy helps to identify the risk of late cardiotoxicity among cancer survivors. There are several biomarkers, already in use or still under study, which may represent an operator-independent alternative for echocardiography in the diagnosis of cardiotoxicity. In case of cardiac damage, the clinician has options for treating or limiting the progression, either with the use of already approved agents, such as Dexrazoxane, or by administrating other cardioprotective drugs. International experts are still attempting to establish the best algorithm for early detection of cardiotoxicity, as well as the most efficient treatment plan in case of already existing myocardial damage in these patients. We present a review on treatment-related cardiotoxicity, including mechanisms of development, useful biomarkers and treatment options, after carefully analyzing specialty literature.
Implications of visfatin genetic variants in the metabolic profile of the Romanian pediatric population
Authors: Vasilache Simona Loredana , Mărginean Cristina Oana , Boaghi Anastasia , Pop Raluca-Monica , Banescu Claudia , Moldovan Valeriu G , Hutanu Adina , Duicu Carmen , Pascanu Ionela Maria 
Published: May 2020

Abstract

Background: Conflictual results regarding the relationship between plasmatic level of visfatin and obesity could be explained by the influence of the gene variants involved in the synthesis or action of these hormones.

Objectives: The present study examined the potential implication of single nucleotide polymorphisms (SNPs) of nicotinamide phosphoribosyltransferase (NAMPT) gene that encodes visfatin, in obesity, in a Romanian pediatric population.

Method: A case-control study was conducted on a group of 213 children, divided into two: the case group - 130 overweight and obese children with BMI >1 SD, and the control group - 83 children with normal BMI. The variables analyzed were age, sex, anthropometric parameters, body composition based on bioimpedance analysis, lipid profile, visfatin and insulin plasmatic levels, rs4730153 and rs2302559 visfatin SNPs.

Results: Significant associations were not found between rs4730153 and rs2302559 visfatin SNPs and obesity. Regarding lipid metabolism, there are statistically significant differences between triglyceride levels according to NAMPT rs2302559 genotypes (p=0.045), with heterozygous genotype having the highest level of triglycerides, and also between cholesterol levels according to NAMPT rs4730153 genotypes (p=0.030), with carriers of heterozygote genotype having the highest level of cholesterol. There is a statistically significant difference between the studied parameters in the investigated groups, regarding cholesterol, in carrier of wild-type genotype of NAMPT rs2302559 (p=0.040) and carrier of wild-type genotype of NAMPT rs4730153 (p=0.036). We observed no association of NAMPT rs4730153 and rs2302559 with visfatin levels in the studied groups. Visfatin level was lower in the case group and was correlated with weight (p=0.042), abdominal circumference (p=0.010), waist to height ratio (p=0.040), but not with the elements of the metabolic profile.

Conclusion: NAMPT rs2302559 and rs4730153 polymorphisms do not seem to have a major impact in the development of obesity in children, however there may be an association with lipid profile, but further studies are needed..
Multiplex ligation-dependent probe amplification – a short overview
Authors: Moldovan Valeriu , Moldovan Elena 
Published: May 2020

Abstract
Multiplex Ligation-dependent Probe Amplification is a technique proposed for the detection of deletions or duplications that may lead to copy number variations in genomic DNA, mainly due to its higher resolution, and shorter overall diagnosis time, when compared with techniques traditionally used, namely karyotyping, fluorescence in situ hybridization, and array comparative genomic hybridization. Multiplex Ligation-dependent Probe Amplification is a fast (about 2 days), useful and cost-effective technique, being suitable for the diagnosis of hereditary conditions caused by complete or partial gene deletions or duplications, as these conditions are either more difficult or impossible to be diagnosed by other techniques, such as PCR, Real-Time PCR, or sequencing (Sanger or Next Generation). Due to its numerous advantages over conventional cytogenetic analysis techniques, Multiplex Ligation-dependent Probe Amplification could be used in the near future as the main technique for the molecular investigation of genetic conditions caused by copy number variations, in both rare and complex genetic disorders.