bluuebunny/crossref_metadata_2025_split huggingface dataset:
Responsiveness of human bronchial fibroblasts and epithelial cells from asthmatic and non-asthmatic donors to the transforming growth factor-β1 in epithelial-mesenchymal trophic unit model
Authors: Paw Milena , Wnuk Dawid , Jakieła Bogdan , Bochenek Grażyna , Sładek Krzysztof , Madeja Zbigniew , Michalik Marta 
Published: December 2020

Abstract
Background: The asthma-related airway wall remodeling is associated i.a. with a damage of bronchial epithelium and subepithelial fibrosis. Functional interactions between human bronchial epithelial cells and human bronchial fibroblasts are known as the epithelial-mesenchymal trophic unit (EMTU) and are necessary for a proper functioning of lung tissue. However, a high concentration of the transforming growth factor-β1 (TGF-β1) in the asthmatic bronchi drives the structural disintegrity of epithelium with the epithelial-to-mesenchymal transition (EMT) of the bronchial epithelial cells, and of subepithelial fibrosis with the fibroblast-to-myofibroblast transition (FMT) of the bronchial fibroblasts. Since previous reports indicate different intrinsic properties of the human bronchial epithelial cells and human bronchial fibroblasts which affect their EMT/FMT potential beetween cells derived from asthmatic and non-asthmatic patients, cultured separatelly in vitro, we were interested to see whether corresponding effects could be obtained in a co-culture of the bronchial epithelial cells and bronchial fibroblasts. In this study, we investigate the effects of the TGF-β1 on the EMT markers of the bronchial epithelial cells cultured in the air-liquid-interface and effectiveness of FMT in the bronchial fibroblast populations in the EMTU models. Results: Our results show that the asthmatic co-cultures are more sensitive to the TGF-β1 than the non-asthmatic ones, which is associated with a higher potential of the asthmatic bronchial cells for a profibrotic response, analogously to be observed in “2D” cultures. They also indicate a noticeable impact of human bronchial epithelial cells on the TGF-β1-induced FMT, stronger in the asthmatic bronchial fibroblast populations in comparison to the non-asthmatic ones. Moreover, our results show the protective effects of fibroblasts on the structure of the TGF-β1–exposed mucociliary differentiated bronchial epithelial cells and their EMT potential.Conclusions: Our data are the first to demonstrate a protective effect of the human bronchial fibroblasts on the properties of the human bronchial epithelial cells, which suggests that intrinsic properties of not only epithelium but also subepithelial fibroblasts affect a proper condition and function of the EMTU in both normal and asthmatic individuals.
Surgical excision of complex lipoma from the foot: a case report&nbsp;
Authors: Uddin Akram , Flanagan George , Reilly Ian 
Published: December 2020

Abstract
Background: Soft tissue malignant tumours of the foot and ankle are rare. Diagnostic imaging and interventional biopsy are vital to establish the nature and grading of a suspicious tumour prior to surgical intervention. The purpose of the study is to provide an account on how a symptomatic mass to the plantar aspect of the foot warranted a referral to a sarcoma centre, highlighting the importance of having urgent access to diagnostic imaging and a pathway to refer suspected cases to specialist centres.Method: A single patient with a symptomatic soft tissue tumour of the plantar foot was referred from our service to the regional sarcoma centre. It was considered to be benign and therefore open surgical resection was performed under local anaesthesia by our team, and the lesion sent for histopathological examination.Results: Histopathological analysis identified the excised mass as a lipoma to show no atypia or necrosis and mature adipose tissue with fibrous bands. At 2 years postoperatively there was no recurrence and the patient presented an asymptomatic foot. Favourable patient reported outcomes measures were observed.Conclusion: United Kingdom (UK) Guidelines suggest that all soft tissue masses of suspicious nature, greater than 50mm, deep seated irrespective of size, or fast growing should be referred to a sarcoma unit prior to surgical management. European guidance identifies a threshold of 15mm for a mass in the foot. Patients presenting with red flag symptoms irrespective of size of mass should be referred to a sarcoma centre. Advanced imaging and multidisciplinary input to enable appropriate surgical planning is recommended for these soft tissue tumours that present to the foot and ankle surgeon. Level of evidence: V case study.
REPRESENTATION OF ROMA IN LITHUANIAN ONLINE MEDIA: 15MIN.LT AND LRYTAS.LT CASE STUDIES
Authors: Sutkutė Rūta 
Published: December 2020

This study focuses on how Roma communities are represented in the Lithuanian online media. The aim is to answer the question of how news about the Roma is embedded in the broader practices of neoliberalism and racist discourses. Representation of the Roma in the media is inseparable from constructivism, power and influence. Roma communities have little opportunity to make their voices heard in society, i.e., their voice is not heard or represented in the media. Political representation of the Roma is particularly important due to the weak opportunities to participate in the formulation and decision-making of certain political decisions, both in the national and international context. It is assumed, that the negative and even stereotypical portrayal of the Roma in the media encourages a negative public attitude towards this ethnic group and has an impact on the (in)successful integration of the Roma into society. The aim of the research is to find out how Roma are represented on the online news portals 15min.lt and Lrytas.lt and to reveal how stereotypes are formed in relation with this national minority. The following tasks are used to reveal the aim of the work: to present the history of the Roma and the problems of their identity, to analyze the concept of Romaphobia, to present the theory of social constructivism and the role of the media in shaping social reality; to perform a qualitative analysis of the content of the news portals 15min.lt and Lrytas.lt: comparing how Roma perceptions are formed on these news portals and how different groups of actors contribute to constructing and maintaining stereotypes in the media/society. The qualitative analysis of the content revealed that the information, provided in the media, aims to portray the Roma as a threat to public security and to the local population, who experience socio-economic exclusion, who have different values and are reluctant to integrate. However, Roma are not given the right to self-representation because the unilateral narrative of the event dominates and the audience for which the report is addressed is too homogeneous. Manifestations of Romaphobia are observed in the news portals' discourse. It can be assumed, that this creates a negative value orientation for readers, as Roma is perceived as an “undesirable” ethnic group in Lithuania. However, the Roma themselves do not have effective means to make heard their “voice” and participate in public life in order to challenge the dominant negative images
Remotely observed variations of reservoir low concentration chromophoric dissolved organic matter and its response to upstream hydrological and meteorological conditions using Sentinel-2 imagery and Gradient Boosting Regression Tree
Authors: Zhang Zeliang , Zhu Weining , Chen Jiang , Cheng Qian 
Published: December 2020

AbstractFreshwater lakes are facing increasingly serious water quality problems. Remote sensing techniques are effective tools for monitoring spatiotemporal information of chromophoric dissolved organic matter (CDOM), a biochemical indicator for water quality. In this study, the Gradient Boosting Regression Tree (GBRT) model and Sentinel-2A/B imagery were combined to estimate low CDOM concentrations (0.003 m−1 &lt; aCDOM(440) &lt;1.787 m−1) in Xin'anjiang Reservoir, an important drinking water resource in Zhejiang Province, China, providing the CDOM distributions and dynamics with high spatial (10 m) and temporal (5 day) resolutions. The possible environmental factors that may affect CDOM spatiotemporal patterns and dynamics were analyzed using Sentinel-2 image-observed data in 2018. Results showed that CDOM in the reservoir exhibited a clear increased gradient from its transition and lacustrine zones to the riverine zones, indicating that the rivers carried a substantial load of organic matter to the lake. The precipitation may increase CDOM concentrations but it has a delayed effect, while it may also shortly decrease CDOM concentrations due to the rainwater dilution. We also found that the correlations between CDOM and water temperature, air pressure, and wind speed were very low, indicating that these factors may not have significant impacts on CDOM variations in the reservoir. This study demonstrated that the GBRT model and Sentinel-2 imagery have the potential to accurately monitor CDOM spatiotemporal variations in reservoirs with low CDOM concentrations, which advances our understanding on the relations between the dissolved organic matter and its coupling environmental factors in river-reservoir systems.
Research on water resources dispatch model based on improved genetic algorithm – water resources dispatch model
Authors: Fu Haoran , Li Huahui 
Published: December 2020

Abstract
According to the research on reservoir water resources scheduling and distribution, the aim is to balance the water supply and demand in each period, and consider the total water supply and the annual external water withdrawal of the reservoir in each period as water rights. The decision-making variables are provided for the water supply of the reservoir in this paper, so that water demand of the water-receiving area can be better met to alleviate the water shortage at various stages and realize the effective use of water resources. Moreover, through the constraints of reservoir operation rules and other constraints, a mathematical model is established for optimal operation of water resources in the reservoir system. Meanwhile, optimized genetic algorithms are applied to solve the model according to the characteristics of the model. After simulation tests, compared with the traditional linear binary algorithm used in the reservoir, the improved genetic algorithm studied in the paper improves the accuracy of data calculation and data convergence, which proves that the research results of the paper provide theoretical and practical significance for improving the level of reservoir water resources management and solving the problem of optimal water resources scheduling.
Analysis capital budgeting investment projects substation 150 kV for tires company
Authors: Setyawan Andi , Hasbullah Hasbullah 
Published: December 2020

The electricity consumption continues to increase, including in Indonesia, where the average electricity consumption rises 6.86% per year. In line with the ever-increasing production needs of companies needing more electrical energy during these electrical disturbances often occur due to power shortage. Therefore, the company proposes the investment of the construction of substations 150kv Expected to improve the reliability of electrical energy supply. This research conducted to analyze the value of investment carried by tire companies using historical data and company forecasts using the technical method of economics to analyze its finances. Based on the calculation result with the Payback period (PP) and Discounted Payback Period generates 5.35 years and 6.24 years. Meanwhile, in the calculation of net present value (NPV) obtained favorable results in the 6th year of Rp 40,944,770,640.32, using an interest rate of 5%. In the calculation of the internal rate of return (IRR), the result of 5.5% concluded that the project return is higher than the minimum attractive rate of return (MARR) of the company by 5.17% of the Bank Indonesia interest rate. Then based on the sensitivity analysis gained that the lower the interest rate on this project, then the faster the return on the investment, and vice versa. The overall analysis of the scenario stated that the investment is worthy of running because it brings profit directly to the company.
“But it’s All Clear: Most Poles and Germans Are Enemies of Russia”: Western Russian Intellectuals on the Polish Issue (Late 19th – early 20th Centuries)
Authors: Timiryaev Denis O. 
Published: December 2020

The article is devoted to the analysis of the publicism on the Polish issue of the three West Russian intellectuals – M.O. Koyalovich, A.S. Budilovich and P.A. Kulakovsky. Publicists expressed their views on all the aspects of the Polish question: the reasons for the division of the Polish-Lithuanian Commonwealth, the debates on the historical and cultural affiliation of the Western Province, granting of autonomy to the Kingdom of Poland, assessment of the experience of solving the Polish question by Austria-Hungary and Germany, participation of the Poles in the First Russian Revolution of 1905–1907. The publicists were convinced that the fall of Poland was the natural result of its historical development, and Russia was not at fault for the Polish destiny. The territories of former Old Russian principalities, incorporated into the Empire, were part of the Russian and not the Polish world. They believed that the Poles had no rights to Western Russia. At the same time, they draw the society’s attention to the existence of the Russian-Polish conflict in the region and its topicality. Publicists argued that Poland’s autonomy would only lead to another Polish rebellion. According to them, Polish autonomy in Galicia demonstrated the true attitude towards the Russian people. A similar situation would be in the Western Province if the Poles could actively pursued the polonization of the Eastern Slavs in the region. Budilovich and Kulakovsky were convinced that the revolution of 1905–1907 was only an instrument of the Poles in achieving their cherished goal – the restoration of the Commonwealth within the borders of 1772.
“Our Cause” in the North-West Region: J.I. Fudel’s Views (1889–1892)
Authors: Vinyukova Nadezhda V. 
Published: December 2020

The article examines the views of the Orthodox priest I.I. Fudel on the position and goals of the Orthodox Church in the North-Western region and on the confessional policy of the Russian Empire in that region. The position of father Joseph, who served in Bialystok for several years, correlates with the opinion of major figures in the public debate on that issue – A.A. Vladimirov, I.P. Kornilov, M.N. Katkov, K.N. Leontiev, – and Slavophil idea. Special attention is paid to the polemics of Fudel and Vladimirov in the «Russian review» journal. The author shows that the idea of «our cause» for father Joseph was precisely the Orthodox mission, which, in turn, would have led to natural, voluntary assimilation of local population. Putting the «religious» above the «national» and «governmental», distinguishing the interests, goals and means of the state and the Church, Fudel did not deny the role of the state principles in the establishment of Orthodoxy in the region, which he saw primarily as imperative of government funding of various Church institutions.
Beneficio tributario de donaciones realizadas a universidades e institutos profesionales en Chile
Authors: Pinto Perry Germán Rodolfo 
Published: December 2020

La presente investigación evaluará la mayor o menor liquidez de recursos monetarios que la aplicación de la disposición contenida en el artículo 69 de la Ley 18.681 les genera a los contribuyentes del Impuesto a la Renta de Primera Categoría que realizan donaciones a universidades e institutos profesionales. Esta disposición legal, que es calificada como un “beneficio tributario”, otorga un crédito del 50% del monto donado y considera el otro 50% como gasto aceptado siempre que cumpla con los requisitos del número 7 del artículo 31 de la Ley sobre Impuestos a la Renta. El objetivo principal es determinar el efecto de dicho beneficio en el flujo y reflexionar sobre la efectividad de los recursos generados en la Operación Renta del Año Tributario 2018.
Se realizó una investigación cualitativa que examinó los articulados pertinentes de la ley ya señalada a través de un proceso de microsimulación tributaria que analizó información pública de contribuyentes que realizaron donaciones y permitió ilustrar la carga tributaria que obtuvieron. Posteriormente, se realizó un análisis numérico que arrojó el resultado de aplicar la mecánica de esta disposición tributaria a las operaciones estudiadas, para luego analizar las cifras generales que el Servicio de Impuestos Internos informó de las declaraciones de la Operación Renta del Año Tributario 2018.
Se obtuvo como resultado que MM$ 12.750 fue el flujo neto social, entendido como el total de recursos que se aplicaron a instituciones de educación superior como donaciones (apreciación cualitativa). También se determinó que la disposición en estudio no es un beneficio sino un “premio” que el legislador otorga a los contribuyentes que realizan donaciones por motivaciones altruistas.
Sala de espera como espaço de promoção da saúde
Authors: Dervanoski Alicia , Pontel Bruna , Deboni Luana , Bordignon Micheli , Nicaretta Ricardo Jose , Boufleuer Teresinha Rita , Castro Thaina Fernanda de 
Published: December 2020

Introdução: A promoção de saúde consolida-se como um processo de empoderamento dos usuários, no qual estimula-se a capacitação, participação e aprendizagem, resultando em autonomia e qualidade de vida¹. A sala de espera nas Unidades Básicas de Saúde (UBS), percebido como lugar e tempo ocioso, torna-se um espaço para ações de saúde coletiva, possibilitando um cuidado humanizado e integral, em sintonia com princípios e diretrizes do Sistema Único de Saúde (SUS) de integralidade, universalidade, equidade, descentralização e a participação da população². O Programa de Educação pelo Trabalho para a Saúde (PET-Saúde), do Ministério da Saúde, contribui nessa direção ao integrar profissionais da Rede de Atenção e a Universidade nas ações de promoção da saúde. A abordagem em sala de espera emerge como uma efetiva estratégia em saúde, que potencializa a troca de conhecimentos, estimula o fortalecimento dos vínculos com a comunidade, além de auxiliar na identificação das necessidades específicas da população³. Objetivo: Relatar a experiência de um grupo do PET-Saúde em abordagens de sala de espera como mecanismo de promoção de saúde, sob ótica da interprofissionalidade. Metodologia: As atividades foram desenvolvidas por um grupo do PET-Saúde na UBS do bairro Saic, município de Chapecó-SC. As abordagens em sala de espera foram desenvolvidas no ano de 2019, relacionadas às campanhas “Setembro Amarelo”, em prevenção ao suicídio, e “Outubro Rosa”, na prevenção ao câncer de mama. As ações interprofissionais envolveram profissionais, docentes e acadêmicos dos cursos de graduação em Educação Física, Fisioterapia, Medicina, Odontologia, Nutrição e Farmácia. Resultados: Em sintonia com os objetivos propostos pelo PET-Saúde, os participantes trabalharam em equipe, de forma interprofissional, cooperativa e colaborativa, planejando e inovando em intervenções em saúde, possibilitando um cuidado integral e articulado aos usuários. As ações na sala de espera incluíram diálogos, troca de conhecimentos e informações com a comunidade, apresentando folders referentes às temáticas do suicídio e câncer de mama disponibilizados pelo município e outros produzidos pelas acadêmicas. Um espaço, originalmente ocioso, tornou-se uma potência para a promoção da saúde. Considerações Finais: A vivência na sala de espera ampliou conceitos de humanização e integralidade na atenção primária em saúde. Percebeu-se que muitos usuários têm necessidades de informações sobre os cuidados na sua saúde, e o diálogo possibilitou acolhimento e troca de informações e experiências sobre assuntos delicados e nem sempre confortáveis de serem falados, como câncer e suicídio. O uso do espaço da sala de espera serviu para a disseminação de informações educativas em saúde, visando a efetividade da integração entre ensino-serviço-comunidade.
Palavras-chave: Educação Interprofissional. Saúde Pública. Promoção da Saúde. Integralidade em Saúde.
O processo de implantação do mapa inteligente virtual no território de abrangência no centro de saúde da família EFAPI, situado no município de Chapecó-SC
Authors: Martiori Sabrina Mara , Kepler Laura Carolina , Frozza Analú , Dalben Bernardo da Veiga , Fistarol Geile , Lunelli Lilian Marin , Dutra Altamir Trevisan , Berlt Suzana Ines 
Published: December 2020

Introdução: A gestão em saúde, de forma participativa, pode ser realizada por meio da confecção de mapas para identificação das necessidades de saúde da comunidade. Neste contexto, o mapa inteligente virtual - (MIV) é uma estratégia criativa que possibilita planejar e compreender o território de forma mais eficiente. Objetivo: Reconhecer o território de abrangência do Centro de Saúde da Família (CSF) - EFAPI, através da confecção de um MIV. Metodologia: Este estudo trata-se de um relato de experiência da confecção de um MIV, realizado pelo grupo PET Interprofissionalidade. A confecção do MIV foi realizada no período de maio e junho de 2019. O grupo manteve contato as Agentes Comunitárias de Saúde (ACS), e a população, realizando reconhecimento do território. A coleta dos dados realizou-se no sistema eletrônico próprio da Secretaria Municipal de Saúde de Chapecó - WinSaúde e a confecção do mapa pela plataforma google maps, registrando em tempo real as informações que foram disponibilizadas pelas equipes do CSF. Resultados: As informações que constaram no MIV retrataram o perfil epidemiológico da comunidade como: número de pacientes com comorbidades crônicas (hipertensos, diabéticos e acamados), número de crianças menores de 2 anos, gestantes, áreas de vulnerabilidade social, focos de mosquito da dengue, locais como escolas e centros comunitários localizados no território. Considerações Finais: A produção do MIV proporcionou exercitar o trabalho efetivo em grupo através de estratégias de territorialização em saúde e obter uma visão holística e humanitária da comunidade. Ao final da confecção do MIV os estudantes destacaram a disponibilidade e a qualidade do trabalho das ACS, auxiliando e organizando as micro áreas para potencializar a prevenção e promoção da saúde. Além de desenvolver estratégias de intervenção voltadas ao auxílio da população junto ao CSF e ainda poder oferecer maior atenção a população com às suas particularidades. Como existe variação nos dados das condições e necessidades de saúde, é importante que o MIV seja atualizado constantemente, assim possibilitará gerar relatórios de saúde ou levantamentos do comportamento populacional de saúde com dados mais precisos.
Palavras-chave: Centro de Saúde. Gestão em Saúde. Agentes Comunitárias da Saúde.