bluuebunny/crossref_metadata_2025_split huggingface dataset:
Voltage‐mode PAM4 driver with differential ternary R‐2R DAC architecture
Authors: Lim B. , Kim D. , Yoo C. 
Published: February 2020

A voltage‐mode pulse‐amplitude modulation 4 (PAM4) driver with differential ternary R‐2R DAC architecture is described. The differential ternary R‐2R DAC provides three voltage levels with one R‐2R branch, whereas the conventional one provides only two. Therefore, much less R‐2R branches are required for a given number of output voltage levels. One of the three voltage levels is realised by simply short circuiting a differential input pair, saving power consumption. Implemented in 65 nm CMOS technology, the voltage‐mode PAM4 driver occupies 0.073 mm2 active silicon area and consumes 1.97 mW/Gbit/s from 1.0 V supply at 10 Gbit/s.
Erkrankungen der Tränendrüse
Authors: Schittkowski Michael P. , Storch Marcus W. 
Published: February 2020

ZusammenfassungIn der augenärztlichen Praxis sind pathologische Veränderungen der Tränendrüse(n) selten anzutreffen. Es überrascht daher nicht, dass sie in augenärztlichen Standardwerken häufig nicht im Detail dargestellt sind. Anliegen dieses Artikels ist es, kompakt notwendiges Basiswissen zusammenzustellen und den Bogen zu wichtigen aktuellen Publikationen zu spannen, um dem Leser nach der Lektüre eine umfassende Kenntnis für die tägliche Praxis zu vermitteln.
Mind the Gap – Forschung und Praxis im Dialog
Authors: Köllner Volker 
Published: February 2020

Liebe Kolleginnen und Kollegen,im Namen unserer beiden Fachgesellschaften DGPM und DKPM sowie des Berliner Kongressteams1 möchte ich Sie sehr herzlich zum Deutschen Kongress für Psychosomatische Medizin und Psychotherapie 2020 einladen.
Substitutionsbehandlung opioidabhängiger Menschen in der medizinischen Rehabilitation
Authors: Funke Wilma , Kuhlmann Thomas , Backmund Markus , Bischof Gallus , Lange Nikolaus , Preuss Ulrich , Rumpf Hans-Jürgen , Rüther Tobias , Thomasius Rainer , Batra Anil 
Published: February 2020

ZusammenfassungDie Opioidsubstitution ist mittlerweile eine etablierte medizinische Maßnahme zur Behandlung opiatabhängiger Menschen. Fast 80 000 Menschen in Deutschland erhalten damit bessere medizinische und psychosoziale Lebensbedingungen.Ungeachtet dessen ist eine Opioidabstinenz das erklärte langfristige Ziel der Behandlung, was allerdings für viele Betroffene nicht herstellbar ist. Unter Substitution ist allerdings der Zugang zu rehabilitativen Leistungen unseres medizinischen Systems erschwert. Um auch diesen Personen eine Chancengleichheit zu ermöglichen, hat der Dachverband der Suchtfachgesellschaft (DSG) ein Positionspapier erarbeitet.Im Konsens der beteiligten Fachgesellschaften wird gefordert, Zugangsschwellen für abstinenzorientierte Angebote im ambulanten, teilstationären und stationären Setting zu senken, reguläre Behandlungsangebote unter durchgehender Substitution ohne eingangs formuliertes Abstinenzziel und Zugangsmöglichkeiten für eine allgemeinmedizinische Rehabilitation auch für Patienten in Substitutionsbehandlungen zu schaffen und stabil substituierten Menschen mit zusätzlichen psychischen Beeinträchtigungen einen leichteren Zugang zu ambulanten, teilstationären und stationären psychotherapeutischen Behandlung zu ermöglichen.
Trichothecenes from an Endophytic Fungus Alternaria sp. sb23
Authors: Gao Ying , Zhou Jia , Ruan Hanli 
Published: February 2020

AbstractThree new (alterchothecenes A – C, 1 –3) and 3 known (4 –6) trichothecenes, along with 9 known compounds (7 –15), were isolated from the culture of Alternaria sp. sb23, an endophytic fungus separated from the root of Schisandra sphenanthera Rehd. et Wils. Their structures were elucidated by spectroscopic analyses, and the absolute configurations of 1–3 were determined through comparison of the experimental electronic circular dichroism (ECD) spectra and optical rotations with similar analogues. In vitro cytotoxicity tests of compounds 1–6 against human HT-29 colon carcinoma and human MCF-7 breast cancer cell lines indicated that 4–6 exhibited significant cytotoxic effects, with IC50 values ranging from 0.89 to 9.38 µM. And the potential of compounds 1–6 as tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) sensitizers in HT-29 cells was evaluated. The results revealed that combination treatment of TRAIL with compounds 1–6 synergistically decreased cell viability compared with the sole treatment with those compounds.
Iron Catalysis in Target Synthesis
Authors: DaBell Peter , Thomas Stephen P. 
Published: February 2020

The use of iron-catalysed organic transformations in the total syntheses of natural products has increased significantly. Iron-catalysed cross-coupling reactions are now widely applied in total syntheses and many other transformations, such as alkene functionalisation, oxidation, and cyclisation. The development of these processes, as well as many examples of their use in target synthesis, is presented here.1	Introduction2	Cross-Coupling Reactions3	Functionalisation of Unactivated Alkenes4	Carbocyclisation Reactions5	Oxidations6	Further Examples7	Conclusions
Perceptions of Clinical Decision-Making Skills among Saudi Nursing Students: A Comparative Study
Authors: AL-Dossary Reem Nassar , Dorgham Sherien Ragab Abdelsamed , Maniago Jestoni Dulva 
Published: February 2020

Abstract
Introduction As complexities in healthcare and medical technology increase, nursing students and newly graduated nurses may often feel less confident and have fewer skills in decision-making than experienced nurses.
Objective The main purpose of this article is to explore nurses’ perceptions of their clinical decision-making skills.
Materials and Methods A comparative, cross-sectional design was used to conduct a study at a college of nursing in the Eastern Province of Saudi Arabia. The sample consisted of students (n = 139) enrolled in bridging (n = 72) and undergraduate (basic; n = 67) programs.
Results Highly statistically significant differences were revealed between students in the bridging program and those in the undergraduate program. Those in the bridging program showed higher mean and median values than did undergraduate students, demonstrating better decision-making skills.
Conclusion Students in the bridging program have better decision-making skills compared with students in the baccalaureate program.
Comparison of Peripheral Arterial Blood Pressure in Individuals with and without Forward Head Posture
Authors: Kadu Dipti Vilas , Shetye Jaimala V. , Mehta Amita 
Published: February 2020

Abstract
Introduction Cervical spine is closely approximated with neurovascular structures. Therefore, misalignment of cervical spine so commonly seen today may lead to altered blood pressure (BP). There could be a relationship between head neck posture as measured by craniovertebral angle and peripheral arterial BP.
Aim The aim of this study is to compare peripheral arterial BP in individuals with and without forward head posture (FHP).
Study Design This is a comparative, prospective, observational study in healthy population.
Subjects and Methods A total of 150 students were selected randomly and screened so that there were equal and desired number of subjects in the two groups (64 in each group) for this comparative, prospective, observational study. Three readings of BP were taken in sitting position on brachial artery at interval of 2 to 3 minutes. One standard image was taken in lateral view used for measuring craniovertebral angle with “MB ruler software.” Craniovertebral angle, systolic blood pressure (SBP), and diastolic blood pressure (DBP) of the two groups were compared.
Results The aim of the study was to compare peripheral arterial BP in individuals with and without FHP. The mean SBP and DBP of both the groups were within the normal range as was expected because the subjects were young students with no clinical symptoms. However, it was seen that the mean SBP was significantly higher in subjects with FHP than in subjects without FHP (p = 0.0009).
Conclusion Peripheral arterial BP in individuals with FHP is statistically significantly higher than in individuals without FHP.
HRI London 2019: 10 Years of Excellence in Homeopathy Research
Authors: Roberts E. Rachel , Mosley Angelina J. , Tournier Alexander L. 
Published: February 2020

AbstractThe Homeopathy Research Institute's (HRI's) 4th International Research Conference took place in the heart of London from 14 to 16 June 2019. With 352 attendees from 38 countries, this was HRI's largest and most international conference to date. HRI London 2019 will be remembered for the highest quality scientific programme so far, combined with a vibrant, positive atmosphere throughout, making it the perfect way to celebrate HRI's 10th Anniversary. Here we summarise the science presented during the intense 2.5-day programme.
The Successful Usage of the DICOM Images Exchange System (ePACS) in the Czech Republic
Authors: Bruthans Jan 
Published: February 2020

Abstract
Background The picture archiving and communication system (PACS) has already replaced classic hard copy film technology. With new functions of PACS under consideration, attention turns to the sharing of medical images between different institutions. The Czech Republic is one of the few countries using a nation-wide medical images exchange system known as ePACS. It is based on dedicated hardware and one central router, although theoretical models tend to prefer cloud-based sharing.
Objective Despite its simple design and lack of advanced features, this system has successively evolved into a widely used tool. The aim of this article is to offer an overview of its use and functions and to show that even a simple system can be widely used.
Methods Using data from the producer of ePACS (the ICZ company) and from other sources, the system was described and data about its performance have been obtained.
Results Every acute-care hospital (140) and about a quarter of outpatient facilities (105) in the Czech Republic are now equipped with ePACS and are therefore able to share medical images. The number of studies transmitted rises every year, from 12,000 in 2008 to more than 640,000 in 2018, which is approximately 4% of all studies produced. The system was primarily designed and is used to share images between acute-care hospitals but a very special usage has also evolved, as it is employed in a teleradiology service with private enterprises too.
Conclusion ePACS is expanding in the Czech Republic despite having only limited functions and despite its principle that simply copies a classic workflow when sending studies on Compact Discs. Although other systems for image sharing might be more advanced, ePACS brings to the Czech health care system the capability to exchange medical images on a national level.
Extramedullary Guide Alignment Is not Affected by Obesity in Primary Total Knee Arthroplasty
Authors: Compton Jocelyn , Owens Jessell , Otero Jesse , Noiseux Nicolas , Brown Timothy 
Published: February 2020

AbstractCoronal alignment of the tibial implant correlates with survivorship of total knee arthroplasty (TKA), especially in obese patients. The purpose of this study was to determine if obesity affects coronal plane alignment of the tibial component when utilizing standard extramedullary tibial guide instrumentation during primary TKA. A retrospective review from June 2017 to February 2018 identified 142 patients (162 primary TKAs). There were 88 patients (100 knees) with body mass index (BMI) < 35 kg/m2 and 54 patients (62 knees) with BMI ≥ 35.0 kg/m2. The cohorts did not differ in age (p = 0.37), gender (p = 0.61), or Charlson's comorbidity index (p = 0.54). Four independent reviewers measured the angle between the base of the tibial component and the mechanical axis of the tibia on the anteroposterior view of long-leg film at first postoperative clinic visit. Outliers were defined as patients with greater than 5 degrees of varus or valgus alignment (n = 0). Reoperations and complications were recorded to 90 days postoperatively. There was no significant difference in mean tibial coronal alignment between the two groups (control alignment 90.8 ± 1.2 degree versus obese alignment 90.8 ± 1.2 degree, p = 0.91). There was no difference in varus versus valgus alignment (p = 0.19). There was no difference in the number of outliers (two in each group, p = 0.73). There was no difference in rate of reoperation (p = 1.0) or complication (p = 0.51). Obesity did not affect coronal plane alignment of the tibial component when using an extramedullary guide during primary TKA in our population.
Perfective marking conditioned by transitivity status in Western Mande
Authors: Idiatov Dmitry 
Published: February 2020

AbstractThis paper provides a diachronic construction-based explanation of the differential perfective marking conditioned by transitivity status in Western Mande languages, using the Greater Manding group as an exemplar case. This typologically unusual phenomenon has previously been erroneously cast in terms of case alignment, either synchronically (in terms of bidirectional case markers) or historically (in terms of an earlier split-ergative stage). The central insight of my explanation is that the Positive Perfective constructions of the Western Mande languages are multiple-source constructions. The in-depth reconstruction of these constructions presented in the paper provides a theoretically significant illustration of a pattern of repeated emergence of constructional competition in a particular semantic domain, which is subsequently resolved through constructional specialization and merger, resulting in multiple-source constructions and a typologically unusual pattern of differential TAM and polarity marking.
Is a difficult task literally heavy?
Authors: Tonković Mirjana , Brdar Mario , Despot Kristina Š. 
Published: February 2020

Abstract
The conceptualization of abstract concepts is very often metaphorical, meaning that we think and talk about abstract concepts in terms of other, usually more concrete experiences. Recent research suggests that many abstract concepts are linked to bodily sensations. In two experiments, we tested a hypothesis about weight as an embodiment of difficulty. We hypothesized that participants wearing a heavy backpack would judge a psychomotor task to be more difficult than participants wearing an empty backpack. We also hypothesized that manipulation of psychomotor task difficulty would affect judgement of backpack heaviness. In line with our hypothesis, the results demonstrated that participants wearing a heavy backpack judged the task to be more difficult. The results of Experiment 2 demonstrated that, regardless of task difficulty, there was no difference in weight judgement when backpack weight was estimated on a 7-point scale. However, we found a difference in the judgement of backpack weight when participants were asked to express it in kilograms, where weight was judged to be lower by participants doing the easy task than by those doing the difficult task.
Spanish in the 2016 U.S. presidential election
Authors: Kirschen Bryan 
Published: February 2020

Abstract
This study analyzes discourse in and about Spanish by presidential hopefuls and their prospective running mates
leading up to the 2016 United States presidential election. I utilize Irvine and Gal’s
(2000) framework of semiotic processes to reveal how Democratic and Republican politicians implement iconization,
fractal recursivity, and erasure in order to appeal to their respective bases. Further, I demonstrate how discourse in and about
Spanish may be considered marked to one party and unmarked to another. Analysis is based on a 70-item corpus consisting of
broadcasted and printed media, as well as content promulgated over social media during this election cycle. In analyzing key
discursive moments that focus on “language”, I address national ideologies as well as latinidad and its
appropriation. As such, this study contributes to an understanding of the role of Spanish and the Latino electorate within the
United States.
“Madrit nos roba”
Authors: Blas Arroyo José Luis 
Published: February 2020

Resumen
A partir de una muestra compuesta por dieciséis políticos que tuvieron un destacado protagonismo en el reciente
procés soberanista catalán, en el artículo se examinan las realizaciones de la consonante /d/ en posición final de
palabra, y en particular, la variante vernácula más próxima a los hábitos articulatorios del catalán, [−t]. Tras el análisis de la
covariación con diversos factores lingüísticos, socioestilísticos e ideolectales a través de diversos modelos de regresión
logística, del estudio se desprende que, junto a una notable variación individual, existe una fuerte asociación con el origen
social de los políticos, pero todavía más con su orientación ideológica en torno al nacionalismo. Este hecho, junto a la no
relevancia de otros condicionantes estructurales y no estructurales, así como algunos datos de estudios previos, da cuenta del
carácter agentivo de la variación en ciertos contextos como el discurso político, y del potencial que para ello tiene el contacto
de lenguas.
Are the systems the same?
Authors: Kanwit Matthew , Pisabarro Sarrió Silvia 
Published: February 2020

AbstractAlthough two languages in contact may contain similar structures, superficial structural similarities may abscond important differences. The comparative method critically determines whether the languages differ in relative rates of variant use, the significance of independent variables, constraint rankings, and ordering within factor groups (Poplack & Tagliamonte 2001). The study explored intensifier (i.e., degree modifier) variation between Spanishmuyandbienand Catalanmoltandben“very”, as based on 84 sets of responses from bilinguals on a 24-item contextualized preference task (40 in Catalan, 44 in Spanish). Results indicated significantly higher selection ofmuyin Spanish thanmoltin Catalan. Moreover, independent variables played a greater role in Spanish, with adjective quality, animacy, and verb type all predicting intensifier selection, whereas in Catalan only adjective quality was predictive. The study provided the first variationist analysis of Catalan intensification, while also revealing key systemic differences between the two languages despite surface similarities.
Use of a Canadian Population-Based Surveillance Cohort to Test Relationships Between Shift Work and Breast, Ovarian, and Prostate Cancer
Authors: Harris M Anne , MacLeod Jill , Kim Joanne , Pahwa Manisha , Tjepkema Michael , Peters Paul , Demers Paul A 
Published: February 2020

Abstract

Objectives
Shift work with circadian disruption is a suspected human carcinogen. Additional population-representative human studies are needed and large population-based linkage cohorts have been explored as an option for surveillance shift work and cancer risk. This study uses a surveillance linkage cohort and job-exposure matrix to test relationships.

Methods
We estimated associations between shift work and breast, ovarian, and prostate cancer using the population-based Canadian Census Health and Environment Cohort (CanCHEC), linking the 1991 Canadian census to national cancer registry and mortality databases. Prevalence estimates from population labour survey data were used to estimate and assign probability of night, rotating, or evening shifts by occupation and industry. Cohort members were assigned to high (&gt;50%), medium (&gt;25 to 50%), low (&gt;5 to 25%), or no (&lt;5%) probability of exposure categories. Cox proportional hazards modelling was used to estimate associations between shift work exposure and incidence of prostate cancer in men and ovarian and breast cancer in women.

Results
The cohort included 1 098 935 men and 939 520 women. Hazard ratios (HRs) indicated null or inverse relationships comparing high probability to no exposure for prostate cancer: HR = 0.96, 95% confidence interval (CI) = 0.91–1.02; breast cancer: HR = 0.94, 95% CI = 0.90–0.99; and ovarian cancer: HR = 0.99, 95% CI = 0.87–1.13.

Conclusions
This study showed inverse and null associations between shift work exposure and incidence of prostate, breast, or ovarian cancer. However, we explore limitations of a surveillance cohort, including a possible healthy worker survivor effect and the possibility that this relationship may require the nuanced exposure detail in primary collection studies to be measurable.
Methplotlib: analysis of modified nucleotides from nanopore sequencing
Authors: De Coster Wouter , Stovner Endre Bakken , Strazisar Mojca 
Published: February 2020

Abstract

Summary
Modified nucleotides play a crucial role in gene expression regulation. Here, we describe methplotlib, a tool developed for the visualization of modified nucleotides detected from Oxford Nanopore Technologies sequencing platforms, together with additional scripts for statistical analysis of allele-specific modification within-subjects and differential modification frequency across subjects.

Availability and implementation
The methplotlib command-line tool is written in Python3, is compatible with Linux, Mac OS and the MS Windows 10 Subsystem for Linux and released under the MIT license. The source code can be found at https://github.com/wdecoster/methplotlib and can be installed from PyPI and bioconda. Our repository includes test data, and the tool is continuously tested at travis-ci.com.

Supplementary information
Supplementary data are available at Bioinformatics online.
BionoiNet: ligand-binding site classification with off-the-shelf deep neural network
Authors: Shi Wentao , Lemoine Jeffrey M , Shawky Abd-El-Monsif A , Singha Manali , Pu Limeng , Yang Shuangyan , Ramanujam J , Brylinski Michal 
Published: February 2020

AbstractMotivationFast and accurate classification of ligand-binding sites in proteins with respect to the class of binding molecules is invaluable not only to the automatic functional annotation of large datasets of protein structures but also to projects in protein evolution, protein engineering and drug development. Deep learning techniques, which have already been successfully applied to address challenging problems across various fields, are inherently suitable to classify ligand-binding pockets. Our goal is to demonstrate that off-the-shelf deep learning models can be employed with minimum development effort to recognize nucleotide- and heme-binding sites with a comparable accuracy to highly specialized, voxel-based methods.ResultsWe developed BionoiNet, a new deep learning-based framework implementing a popular ResNet model for image classification. BionoiNet first transforms the molecular structures of ligand-binding sites to 2D Voronoi diagrams, which are then used as the input to a pretrained convolutional neural network classifier. The ResNet model generalizes well to unseen data achieving the accuracy of 85.6% for nucleotide- and 91.3% for heme-binding pockets. BionoiNet also computes significance scores of pocket atoms, called BionoiScores, to provide meaningful insights into their interactions with ligand molecules. BionoiNet is a lightweight alternative to computationally expensive 3D architectures.Availability and implementationBionoiNet is implemented in Python with the source code freely available at: https://github.com/CSBG-LSU/BionoiNet.Supplementary informationSupplementary data are available at Bioinformatics online.