bluuebunny/crossref_metadata_2025_split huggingface dataset:
The unaccomplished mission of reducing mortality in patients on kidney replacement therapy
Authors: Ortiz Alberto 
Published: October 2020

Abstract
Six years ago, a comprehensive review by the EURECA-m working group of the ERA-EDTA thoroughly addressed the drivers of mortality in patients with end-stage kidney disease. Not unexpectedly, the key global driver of early death in these patients was the lack of access to kidney replacement therapy. However, and contrary to the expectations of non-nephrologists, mortality was still high when kidney replacement therapy was provided. This was due to excess cardiovascular and non-cardiovascular mortality, and the need to further characterize correctable risk factors and eventually test the impact of correcting them was emphasized. In this issue of ckj, seven reports address risk factors for death in non-dialysis chronic kidney disease (CKD), dialysis and kidney transplant patients. They characterize irreversible (e.g. sex; age; genetic variants of the KL gene encoding the anti-ageing protein Klotho) and reversible (obesity; mineral and bone disorder parameters; anti-depressant drugs, especially those that increase the QT; amputation; public health investments) factors associated with mortality of CKD patients on or off kidney replacement therapy.
Network medicine in Cardiovascular Research
Authors: Lee Laurel Y , Pandey Arvind K , Maron Bradley A , Loscalzo Joseph 
Published: October 2020

Abstract
The ability to generate multi-omics data coupled with deeply characterizing the clinical phenotype of individual patients promises to improve understanding of complex cardiovascular pathobiology. There remains an important disconnection between the magnitude and granularity of these data and our ability to improve phenotype–genotype correlations for complex cardiovascular diseases. This shortcoming may be due to limitations associated with traditional reductionist analytical methods, which tend to emphasize a single molecular event in the pathogenesis of diseases more aptly characterized by crosstalk between overlapping molecular pathways. Network medicine is a rapidly growing discipline that considers diseases as the consequences of perturbed interactions between multiple interconnected biological components. This powerful integrative approach has enabled a number of important discoveries in complex disease mechanisms. In this review, we introduce the basic concepts of network medicine and highlight specific examples by which this approach has accelerated cardiovascular research. We also review how network medicine is well-positioned to promote rational drug design for patients with cardiovascular diseases, with particular emphasis on advancing precision medicine.
The Benefits of Omnivory for Reproduction and Life History of a Specialized Aphid Predator,Hippodamia convergens(Coleoptera: Coccinellidae)
Authors: Stowe Hannah E , Michaud J P , Kim Tania 
Published: October 2020

AbstractThe convergent lady beetle, Hippodamia convergens Guerin-Meneville, is a specialized predator of cereal aphids on the High Plains, completing its first generation each year in winter wheat, the resulting adults dispersing into summer crops and producing additional generations, contingent on the availability of aphids. In the present study, we tested the collective value of supplementary plant resources (sugars, pollen, and seedling wheat leaves), and small amounts of alternative prey, eggs of Ephestia kuehniella (Zeller) (Lepidoptera: Pyralidae), all provided together, for improving beetle life history and reproductive success even when suitable prey, Schizaphis graminum (Rondani) (Hemiptera: Aphididae), were provided ad libitum. Although a monotypic diet of S. graminum yielded slightly faster larval development and heavier adults than the omnivorous diet, preoviposition periods were extended and 21-d fecundities greatly reduced when this diet was continued through adult life, largely due to fewer oviposition days, although egg fertility was unaffected. The results highlight the critical importance of plant-derived resources even when suitable prey are not limiting. However, monotypic diet beetles that diapaused for 21 d in the presence of supplementary plant resources, plus moth eggs, achieved the same reproductive success as those reared on the omnivorous diet, with or without diapause, demonstrating that access to these resources post-emergence was sufficient to compensate for their absence during development. The diapause treatment itself had no impact on the fitness of beetles reared on the omnivorous diet, likely because neither its duration, nor the caloric restriction imposed, were sufficient to diminish reproductive effort.
Fake Reviews
Authors: Glazer Jacob , Herrera Helios , Perry Motty 
Published: October 2020

Abstract
We propose a model of product reviews in which some are genuine and some are fake in order to shed light on the value of information provided on platforms like TripAdvisor, Yelp, etc. In every period, a review is posted which is either genuine or fake. We characterise the equilibrium of the dynamic model and prove that it is unique. In equilibrium, valuable learning takes place in every period. Fake reviews, however, do slow down the learning process. It is established that any attempt by the platform to manipulate the reviews is counterproductive.
Vegetarians, fish, poultry, and meat-eaters: who has higher risk of cardiovascular disease incidence and mortality? A prospective study from UK Biobank
Authors: Petermann-Rocha Fanny , Parra-Soto Solange , Gray Stuart , Anderson Jana , Welsh Paul , Gill Jason , Sattar Naveed , Ho Frederick K , Celis-Morales Carlos , Pell Jill P 
Published: October 2020

AbstractAims To compare the incidence and mortality risk for cardiovascular diseases (CVD) [CVD and also ischaemic heart disease (IHD), myocardial infarction (MI), stroke, and heart failure (HF)] among people with different types of diets—including vegetarians, fish eaters, fish and poultry eaters, and meat-eaters—using data from UK Biobank.Methods and results A total of 422 791 participants (55.4% women) were included in this prospective analysis. Using data from a food frequency questionnaire, four types of diets were derived. Associations between types of diets and health outcomes were investigated using Cox proportional hazard models. Meat-eaters comprised 94.7% of the cohort and were more likely to be obese than other diet groups. After a median follow-up of 8.5 years, fish eaters, compared with meat-eaters, had lower risks of incident CVD {hazard ratios (HR): 0.93 [95% confidence intervals (CI): 0.88–0.97]}, IHD [HR: 0.79 (95% CI: 0.70–0.88)], MI [HR: 0.70 (95% CI: 0.56–0.88)], stroke [HR: 0.79 (95% CI: 0.63–0.98)] and HF [HR: 0.78 (95% CI: 0.63–0.97)], after adjusting for confounders. Vegetarians had lower risk of CVD incidence [HR: 0.91 (95% CI: 0.86–0.96)] relative to meat-eaters. In contrast, the risk of adverse outcomes was not different in fish and poultry eaters compared with meat-eaters. No associations were identified between types of diets and CVD mortality.Conclusion Eating fish rather than meat or poultry was associated with a lower risk of a range of adverse cardiovascular outcomes. Vegetarianism was only associated with a lower risk of CVD incidence.
Measuring the quality of cancer care in the Barwon South Western region, Victoria, Australia
Authors: Matheson L M , Pitson G , Yap C H , Singh M , Collins I , Campbell P , Patrick A , Rogers M J 
Published: October 2020

Abstract

Objective
The implementation of clinical quality indicators for monitoring cancer care in regional, rural and remote areas.

Design
Retrospective data from a population-based Clinical Quality Registry for lung, colorectal and breast cancers.

Setting
All major health services in the Barwon South Western region, Victoria, Australia.

Participants
All patients who were diagnosed with cancer and who presented to a health service.

Intervention(s)
Clinical subgroups to review variations.

Main Outcome Measures(s)
Clinical quality indicators for lung, colorectal and breast cancers.

Results
Clinical indicators included the following: discussion at multidisciplinary meetings, the timeliness of care provided and the type of care for different stages of the disease and survival outcomes. Many of the derived clinical indicator targets were reached. However, variations led to an improvement in the tumour stage being recorded in the medical record; an improved awareness of the need for adjuvant chemotherapy for colorectal cancer; a reduction in time to treatment for lung cancer and a reduced time to surgery for breast cancer, and the 30-day mortality post-treatment for all of the tumour streams was highlighted.

Conclusions
Clinical quality indicators allow for valuable insights into patterns of care. These indicators are easily reproduced and may be of use to other cancer centres and health services.
Optimizing aminoglycoside selection for KPC-producing Klebsiella pneumoniae with the aminoglycoside-modifying enzyme (AME) gene aac(6’)-Ib
Authors: Butler David A , Rana Amisha P , Krapp Fiorella , Patel Shitalben R , Huang Yanqin , Ozer Egon A , Hauser Alan R , Bulman Zackery P 
Published: October 2020

Abstract

Objectives
KPC-producing Klebsiella pneumoniae (KPC-Kp) isolates commonly co-harbour the aminoglycoside-modifying enzyme (AME) gene aac(6’)-Ib, which encodes an AME that can confer resistance to some of the commercially available aminoglycosides. We sought to determine the influence of AAC(6’)-Ib in KPC-Kp on the pharmacodynamic activity of aminoglycosides.

Methods
Six KPC-Kp clinical isolates, three with and three without aac(6’)-Ib, were analysed. Using these isolates, the bacterial killing of amikacin, gentamicin and tobramycin was assessed in static time–kill experiments. The pharmacodynamic activity of the aminoglycosides was then assessed in a dynamic one-compartment infection model over 72 h using simulated human pharmacokinetics of once-daily dosing with amikacin (15 mg/kg), gentamicin (5 mg/kg) and tobramycin (5 mg/kg).

Results
At clinically relevant aminoglycoside concentrations in time–kill experiments and the dynamic one-compartment model, gentamicin was more active than amikacin or tobramycin against the isolates harbouring aac(6’)-Ib. Amikacin, gentamicin and tobramycin all showed progressively reduced bacterial killing with exposure to repeated doses against most isolates in the dynamic one-compartment model. MIC values were generally not a good predictor of gentamicin pharmacodynamic activity against KPC-Kp, but were more reliable for amikacin and tobramycin.

Conclusions
Gentamicin may be preferred over amikacin or tobramycin for treatment of KPC-Kp infections. However, gentamicin MICs are not a consistent predictor of its pharmacodynamic activity and unexpected treatment failures are possible.
Persistent inequitable design and implementation of patient portals for users at the margins
Authors: Goedhart Nicole S , Zuiderent-Jerak Teun , Woudstra Joey , Broerse Jacqueline E W , Betten Afke Wieke , Dedding Christine 
Published: October 2020

Abstract

Objective
Diane Forsythe and other feminist scholars have long shown how system builders’ tacit assumptions lead to the systematic erasure of certain users from the design process. In spite of this phenomena being known in the health informatics literature for decades, recent research shows how patient portals and electronic patients health records continue to reproduce health inequalities in Western societies. To better understand this discrepancy between scholarly awareness of such inequities and mainstream design, this study unravels the (conceptual) assumptions and practices of designers and others responsible for portal implementation in the Netherlands and how citizens living in vulnerable circumstances are included in this process.

Materials and methods
We conducted semistructured interviews (n = 24) and questionnaires (n = 14) with portal designers, health professionals, and policy advisors.

Results
In daily design practices, equity is seen as an “end-of-the-pipeline” concern. Respondents identify health care professionals rather than patients as their main users. If patients are included in the design, this generally entails patients in privileged positions. The needs of citizens living in vulnerable circumstances are not prioritized in design processes. Developers legitimize their focus with reference to the innovation-theoretical approach of the Diffusion of Innovations.

Discussion and conclusion
Although feminist scholars have developed important understandings of the exclusion of citizens living in vulnerable circumstances from portal design, other academic efforts have profoundly shaped daily practices of portal development. Diane Forsythe would likely have taken up this discrepancy as a challenge by finding ways to translate these insights into mainstream systems design.
Patient-centered care and the electronic health record: exploring functionality and gaps
Authors: Butler Jorie M , Gibson Bryan , Lewis Lacey , Reiber Gayle , Kramer Heidi , Rupper Rand , Herout Jennifer , Long Brenna , Massaro David , Nebeker Jonathan 
Published: October 2020

Abstract

Objective
Healthcare systems have adopted electronic health records (EHRs) to support clinical care. Providing patient-centered care (PCC) is a goal of many healthcare systems. In this study, we sought to explore how existing EHR systems support PCC; defined as understanding the patient as a whole person, building relational connections between the clinician and patient, and supporting patients in health self-management.

Materials and Methods
We assessed availability of EHR functions consistent with providing PCC including patient goals and preferences, integrated care plans, and contextual and patient-generated data. We surveyed and then interviewed technical representatives and expert clinical users of 6 leading EHR systems. Questions focused on the availability of specific data and functions related to PCC (for technical representatives) and the clinical usefulness of PCC functions (for clinicians) in their EHR.

Results
Technical representatives (n = 6) reported that patient communication preferences, personalized indications for medications, and end of life preferences were functions implemented across 6 systems. Clinician users (n = 10) reported moderate usefulness of PCC functions (medians of 2–4 on a 5-pointy -35t scale), suggesting the potential for improvement across systems. Interviews revealed that clinicians do not have a shared conception of PCC. In many cases, data needed to deliver PCC was available in the EHR only in unstructured form. Data systems and functionality to support PCC are under development in these EHRs.

Discussion and Conclusion
There are current gaps in PCC functionality in EHRs and opportunities to support the practice of PCC through EHR redesign.
Genetic association among feeding behavior, feed efficiency, and growth traits in growing indicine cattle
Authors: Benfica Lorena Ferreira , Sakamoto Leandro Sannomiya , Magalhães Ana Fabrícia Braga , de Oliveira Matheus Henrique Vargas , de Albuquerque Lúcia Galvão , Cavalheiro Roberto , Branco Renata Helena , Cyrillo Joslaine Noely dos Santos Goncalves , Mercadante Maria Eugênia Zerlotti 
Published: October 2020

Abstract
This study aimed to estimate genetic parameters, including genomic data, for feeding behavior, feed efficiency, and growth traits in Nellore cattle. The following feeding behavior traits were studied (861 animals with records): time spent at the feed bunk (TF), duration of one feeding event (FD), frequency of visits to the bunk (FF), feeding rate (FR), and dry matter intake (DMI) per visit (DMIv). The feed efficiency traits (1,543 animals with records) included residual feed intake (RFI), residual weight gain (RWG), and feed conversion (FC). The growth traits studied were average daily gain (ADG, n = 1,543 animals) and selection (postweaning) weight (WSel, n = 9,549 animals). The (co)variance components were estimated by the maximum restricted likelihood method, fitting animal models that did (single-step genomic best linear unbiased prediction) or did not include (best linear unbiased prediction) genomic information in two-trait analyses. The direct responses to selection were calculated for the feed efficiency traits, ADG, and WSel, as well as the correlated responses in feed efficiency and growth by direct selection for shorter TF. The estimated heritabilities were 0.51 ± 0.06, 0.35 ± 0.06, 0.27 ± 0.07, 0.34 ± 0.06, and 0.33 ± 0.06 for TF, FD, FF, FR, and DMIv, respectively. In general, TF and FD showed positive genetic correlations with all feed efficiency traits (RFI, RWG, and FC), ADG, DMI, and WSel. Additionally, TF showed high and positive genetic and phenotypic correlations with RFI (0.71 ± 0.10 and 0.46 ± 0.02, respectively) and DMI (0.56 ± 0.09 and 0.48 ± 0.03), and medium to weak genetic correlations with growth (0.32 ± 0.11 with ADG and 0.14 ± 0.09 with WSel). The results suggest that TF is a strong indicator trait of feed efficiency, which exhibits high heritability and a weak positive genetic correlation with growth. In a context of a selection index, the inclusion of TF to select animals for shorter TF may accelerate the genetic gain in feed efficiency by reducing RFI but with zero or slightly negative genetic gain in growth traits.
Visualization of endogenous nuclear F-actin in mouse embryos reveals abnormal actin assembly after somatic cell nuclear transfer
Authors: Shindo Taiki , Ihashi Shunya , Sakamoto Yuko , Okuno Tomomi , Tomikawa Junko , Miyamoto Kei 
Published: October 2020

Abstract
Actin in the nucleus, referred to as nuclear actin, is involved in a variety of nuclear events. Nuclear actin is present as a globular (G-actin) and filamentous form (F-actin), and dynamic assembly/disassembly of nuclear actin profoundly affects nuclear functions. However, it is still challenging to observe endogenous nuclear F-actin. Here, we present a condition to visualize endogenous nuclear F-actin of mouse zygotes using different fixation methods. Zygotes fixed with paraformaldehyde and treated with fluorescently conjugated phalloidin show both short and long actin filaments in their pronuclei. Short nuclear actin filaments are characteristic of phalloidin staining, rather than the consequence of severing actin filaments by the fixation process, since long nuclear actin filaments probed with the nuclear actin chromobody are not disassembled into short filaments after fixation with paraformaldehyde. Furthermore, we find that nuclear actin assembly is impaired after somatic cell nuclear transfer (SCNT), suggesting abnormal nucleoskeleton structures in SCNT embryos. Taken together, our presented method for visualizing nuclear F-actin with phalloidin can be used to observe the states of nuclear actin assembly, and revealed improper reprogramming of actin nucleoskeleton structures in cloned mouse embryos.
Vacuum Steam Treatment Effectiveness for Eradication of the Thousand Cankers Disease Vector and Pathogen in Logs From Diseased Walnut Trees
Authors: Juzwik Jennifer , Yang Anna , Heller Sarah , Moore Melanie , Chen Zhangjing , White Marshall , Wantuch Holly , Ginzel Matthew , Mack Ron 
Published: October 2020

Abstract
Logs of high-value eastern black walnut (Juglans nigra L.) are commonly exported from the United States for production of veneer and lumber. Veneer logs are not debarked to minimize degradation of wood quality and reduce moisture loss. Thousand cankers disease (TCD) is caused by the walnut twig beetle (Pityophthorus juglandis Blackman) and the fungal pathogen, Geosmithia morbida M. Kolarik, E. Freeland, C. Utley and N. Tisserat sp. nov., which colonize the inner bark of Juglans species. Effective eradication of these organisms by heat or chemical fumigation treatment is required for walnut logs prior to export. Because vacuum steam is an effective and efficient means of heating round wood, its use in eliminating the TCD causal agents was evaluated using Juglans logs (12- to 44-cm small end diameter and 1.7- to 1.9-m length) from TCD-symptomatic trees in Oregon and Washington State. Five replicate trials with three logs per load were conducted in a portable vacuum chamber to test two treatment schedules: 60°C for 60 min and 56°C for 30 min. Complete elimination of P. juglandis and G. morbida was achieved when using a minimum of 56°C at 5-cm targeted depth from bottom of bark furrow into the sapwood and held for 30 min. Treatment cycle time ranged from 298 to 576 min depending on log diameter and initial log temperature. Artificial inoculation of J. nigra trees with G. morbida within the TCD range in Pennsylvania was minimally successful in producing adequately colonized logs for experimental trials.
Generation-Dependent Functional and Numerical Responses of a Naturally Fungus-Infected Colony ofHabrobracon hebetor(Hymenoptera: Braconidae) Reared onEphestia kuehniella(Lepidoptera: Pyralidae) in Iran
Authors: Badran Fatima , Fathipour Yaghoub , Bagheri Abdoolnabi , Attaran Mohammadreza , Reddy Gadi V P 
Published: October 2020

AbstractThe functional and numerical responses of Habrobracon hebetor (Say) were assessed over 30 sequential generations (G) on different densities (2, 4, 8, 16, 32, 64, and 128 fifth-instar larvae) of the Mediterranean flour moth, Ephestia kuehniella (Zeller). Seven tested generations (G2inf, G4inf, G6inf, G8inf, G10inf, G15inf, and G30inf) had already been naturally infected by a fungus species, whereas only the second generation (G2) had the colonies of both infected (G2inf) and uninfected (G2uninf) individuals. All infected generations, as well as the uninfected generation, showed a Type III functional response. A high variation was found in the handling times (Th) of the parasitoid through 30 sequential generations, and G10inf had the longest handling time. The shortest handling time and the maximum estimated attack rate (T/Th) were observed in G2inf. No significant difference in terms of the number of parasitized hosts was found among all infected generations, as well as between G2inf and G2uninf. Although the handling times in G2inf and G2uninf were close to each other, the attack coefficient of G2uninf was more than that of G2inf. The attack coefficient and handling time of infected generations increased from G2inf to G10inf and then decreased in the higher generations. The most plausible parameters of functional response of infected generations were observed in Ginf. A negative relationship between eggs laid and host densities was observed in the infected generations (G2inf, G4inf, G6inf, G8inf, and G10inf). G2uninf and, among infected generations, Ginf were the best generations for practical utilization in inundative release programs.