bluuebunny/crossref_metadata_2025_split huggingface dataset:
ApproXON: Heuristic Approximation to the E-Field-Threshold for Deep Brain Stimulation Volume-of-Tissue-Activated Estimation
Authors: Proverbio Daniele , Husch Andreas 
Published: December 2019

AbstractThis paper introduces a heuristic approximation of the e-field threshold used for volume-of-tissue-activated computation in deep brain stimulation. Pulse width and axon diameter are used as predictors. An open source implementation in MATLAB is provided together with an integration in the open LeadDBS deep brain stimulation research toolbox.
LEARNING AND INTERPRETING THE GENE REGULATORY GRAMMAR IN A DEEP LEARNING FRAMEWORK
Authors: Chen Ling , Capra John A. 
Published: December 2019

AbstractDeep neural networks (DNNs) have achieved state-of-the-art performance in identifying gene regulatory sequences, but they have provided limited insight into the biology of regulatory elements due to the difficulty of interpreting the complex features they learn. Several models of how combinatorial binding of transcription factors, i.e. the regulatory grammar, drives enhancer activity have been proposed, ranging from the flexible TF billboard model to the stringent enhanceosome model. However, there is limited knowledge of the prevalence of these (or other) sequence architectures across enhancers. Here we perform several hypothesis-driven analyses to explore the ability of DNNs to learn the regulatory grammar of enhancers. We created a synthetic dataset based on existing hypotheses about combinatorial transcription factor binding site (TFBS) patterns, including homotypic clusters, heterotypic clusters, and enhanceosomes, from real TF binding motifs from diverse TF families. We then trained deep residual neural networks (ResNets) to model the sequences under a range of scenarios that reflect real-world multi-label regulatory sequence prediction tasks. We developed a gradient-based unsupervised clustering method to extract the patterns learned by the ResNet models. We demonstrated that simulated regulatory grammars are best learned in the penultimate layer of the ResNets, and the proposed method can accurately retrieve the regulatory grammar even when there is heterogeneity in the enhancer categories and a large fraction of TFBS outside of the regulatory grammar. However, we also identify common scenarios where ResNets fail to learn simulated regulatory grammars. Our results provide a framework for interpreting the regulatory rules learned by ResNets, and they demonstrate that the ability and efficiency of ResNets in learning the regulatory grammar highly depends on the nature of the prediction task.
Maternal Obesity and Western-style Diet Impair Fetal and Juvenile Offspring Skeletal Muscle Insulin-Stimulated Glucose Transport in Nonhuman Primates
Authors: Campodonico-Burnett William , Hetrick Byron , Wesolowski Stephanie R. , Schenk Simon , Takahashi Diana L. , Dean Tyler A. , Sullivan Elinor L. , Kievit Paul , Gannon Maureen , Aagaard Kjersti , Friedman Jacob E. , McCurdy Carrie E. 
Published: December 2019

AbstractInfants born to mothers with obesity have a greater risk for childhood obesity and metabolic diseases; however, the underlying biological mechanisms remain poorly understood. We used a nonhuman primate model to investigate whether maternal obesity combined with a western-style diet (WSD) impairs offspring muscle insulin action. Briefly, adult females were fed a control (CON) or WSD prior to and during pregnancy and lactation. Offspring were weaned to a CON or WSD. Muscle glucose uptake and insulin signaling were measuredex vivoin fetal and juvenile offspring.In vivosignaling was evaluated before and after an intravenous insulin bolus just prior to weaning. We find that fetal muscle exposed to maternal WSD had reduced insulin-stimulated glucose uptake and impaired insulin signaling. In juvenile offspring, insulin-stimulated glucose uptake was similarly reduced by both maternal and post-weaning WSD. Analysis of insulin signaling activation revealed distinct changes between fetal and post-weaning WSD exposure. We conclude that maternal WSD leads to a persistent decrease in insulin-stimulated glucose uptake in juvenile offspring even in the absence of increased offspring adiposity or markers of systemic insulin resistance. Switching offspring to a healthy diet did not ameliorate the effects of maternal WSD suggesting earlier interventions may be necessary.
Effect of storage on retinol content and total antioxidant capacity of human milk
Authors: Chaves Jaísa Oliveira , Fernandes Angelica Maria de Freitas , Parreiras Paola Machado , Breguez Gustavo Silveira , Passos Maria Cristina , da Cunha Luciana Rodrigues , Menezes Camila Carvalho 
Published: December 2019

Purpose
The purpose of this paper is to evaluate the effect of different times and freezing temperatures on the antioxidant activity of raw human milk (HM) and the impact of light by different packaging on retinol level and the antioxidant activity of pasteurized HM.

Design/methodology/approach
Donor milks were homogenized to form the pool of the experimental study characterized by the evaluation of the effects of time (0, 2, 4, 8 and 15 days) freezing temperatures (−3°C, −8°C and −18°C) and the interference of the type of packaging on the antioxidant activity and retinol levels of HM.

Findings
The existing studies do not reveal the real impact of HM storage conditions adopted by human milk banks (HMB) in Brazil on their compounds, mainly in relation to the effects of temperature and freezing time and the incidence of light on retinol levels and antioxidant activity. In view of the already documented importance of these compounds for the growth, development and health of children, it is extremely important to assess their stability according to the procedures adopted by the banks. It has been observed in this study that lower freezing temperatures (−18°C) further preserve the antioxidant activity. It was found that the amber and transparent vials wrapped with aluminum foil allowed for greater retinol stability of HM, with values of 2.501±0.757 µmol/L and 4.991±0.825 µmol/L, respectively. On the contrary, there was no significant influence on antioxidant activity.

Originality/value
It is suggested that HMB store milk at lower temperatures and use glass jars that block the passage of light.
Effects of perceived brand authenticity in health functional food consumers
Authors: Lee Jisun , Chung Lana 
Published: December 2019

PurposeThe purpose of this paper is to empirically analyze how brand authenticity (BA) as perceived by consumers who take health functional foods (HFF) strengthen the brand relationship quality (BRQ) and positively affects brand loyalty.Design/methodology/approachThe five sub-dimensions of BA perceived by HFF consumers, elicited through a focus group interview, were conceptualized as a second-order reflective construct. To identify the influences of the sub-dimensions of BA on each construct of the BRQ and the influence on brand loyalty though mediating BRQ, an empirical analysis was done using partial least squares-based structural equation modeling.FindingsAll the sub-dimensions of BA positively affect each of the BRQ s (brand satisfaction, brand trust and brand commitment) excepting product authenticity on brand commitment, and originality on brand trust. The impact of BA positively affects brand loyalty by mediating brand relationship qualities.Originality/valueIt is found that BA is an important antecedent for forming BRQ with consumers in the HFF industry, in which building trust with consumers is important. BA is an important factor in brand management of HFF.
House price estimation using an eigenvector spatial filtering approach
Authors: McCord Michael James , McCord John , Davis Peadar Thomas , Haran Martin , Bidanset Paul 
Published: December 2019

PurposeNumerous geo-statistical methods have been developed to analyse the spatial dimension and composition of house prices. Despite these advances, spatial filtering remains an under-researched approach within house price studies. This paper aims to examine the spatial distribution of house prices using an eigenvector spatial filtering (ESF) procedure, to analyse the local variation and spatial heterogeneity.Design/methodology/approachUsing 2,664 sale transactions over the one year period Q3 2017 to Q3 2018, an eigenvector spatial filtering approach is applied to evaluate spatial patterns within the Belfast housing market. This method consists of using geographical coordinates to specify eigenvectors across geographic distance to determine a set of spatial filters. These convey spatial structures representative of different spatial scales and units. The filters are incorporated as predictors into regression analyses to alleviate spatial autocorrelation. This approach is intuitive, given that detection of autocorrelation in specific filters and within the regression residuals can be markers for exclusion or inclusion criteria.FindingsThe findings show both robust and effective estimator consistency and limited spatial dependency – culminating in accurately specified hedonic pricing models. The findings show that the spatial component alone explains 14.6 per cent of the variation in property value, whereas 77.6 per cent of the variation could be attributed to an interaction between the structural characteristics and the local market geography expressed by the filters. This methodological step reduced short-scale spatial dependency and residual autocorrelation resulting in increased model stability and reduced misspecification error.Originality/valueEigenvector-based spatial filtering is a less known but suitable statistical protocol that can be used to analyse house price patterns taking into account spatial autocorrelation at varying (different) spatial scales. This approach arguably provides a more insightful analysis of house prices by removing spatial autocorrelation both objectively and subjectively to produce reliable, yet understandable, regression models, which do not suffer from traditional challenges of serial dependence or spatial mis-specification. This approach offers property researchers and policymakers an intuitive but comprehensible approach for producing accurate price estimation models, which can be readily interpreted.
The sustainability of outcomes in temporary co-production
Authors: Jaspers Sylke , Steen Trui 
Published: December 2019

Purpose
The temporary use of vacant spaces as a format to co-produce public services is becoming popular. Research addressing the question of whether the public outcomes created in temporary co-production lead to sustainable results is lacking. The purpose of this paper is to explore the potential sustainability of public outcomes created through temporary co-production.

Design/methodology/approach
The paper builds on the literature on creating sustainable outcomes in policy making and on co-production to design a theoretical framework that captures the sustainable co-production of public outcomes. Attention is directed to problem solving and capacity building, and to addressing the needs of society today and being responsive to the needs of tomorrow. A study of 8 temporary initiatives set in a large city in Flanders and 35 in-depth interviews with public servants, project coordinators and citizen co-producers provide empirical data for this exploratory study of the creation of sustainable outcomes in temporary co-production.

Findings
The data indicate that lasting collaborations, institutionalized (flexible) processes and empowered citizens support the creation of sustainable results from temporary co-production.

Originality/value
The paper bridges the literature on policy capacity, the co-production of public services and value creation. By doing so, the paper sheds light on the temporary use of vacant spaces as a way to effectively create outcomes. In addition, the paper addresses the paradox of temporary co-production and the creation of lasting outcomes. Finally, the framework presented offers a tool for analysts and practitioners to take into account various conditions for co-production to create lasting effects.
Self-deception, emotional neglect and workplace victimization
Authors: Dash Sanket Sunand , Jena Lalatendu Kesari 
Published: December 2019

PurposeThe purpose of this paper is to define workplace victimization as any behavior that impairs employees’ basic psychological needs and explores the mutually interactive association between trait self-deception; emotional neglect, especially by supervisors, and workplace victimization.Design/methodology/approachWorkplace victimization is identified as a pervasive problem in organization. This paper zeroes in on self-deception and emotional neglect as two possible antecedents of workplace victimization, explores the genesis of the two concepts and analyzes their conceptual relationship with each other and with workplace victimization. Based on the conceptual analysis, it identifies the lack of intentionality as a common element in both constructs and identifies a set of possible frameworks linking self-deception, emotional neglect and workplace victimization for future research.FindingsThis paper explores four possible frameworks to model the expected association while advocating for investigation of these given models to check whether one has considerable expository success than other by either connecting or disassociating these two constructs.Research limitations/implicationsThe amount of linkage between self-deception and emotional neglect at workplace is worth investigating, and this research paper presents several possible models that might help to focus and organize the future workplace investigations.Practical implicationsThe current paper postulates that supervisors’ and subordinates’ ability to display appropriate leadership and follower behavior and interaction will be impaired if they are high in trait self-deception and have been the victim or perpetrators of emotional neglect.Originality/valueIn the workplace, self-deceptive individuals display behaviors such as conscientiousness, resilience, optimism and competitiveness that are considered characteristics of good employees and, hence, are more likely to be promoted to supervisory positions, where emotional neglect of others such as subordinates becomes more pertinent.
The effects of organizational culture and commitment on employee innovation: evidence from Vietnam’s IT industry
Authors: Nguyen Vinh The , Siengthai Sununta , Swierczek Fredric , Bamel Umesh Kumar 
Published: December 2019

PurposeThis paper aims to analyze the relationship between organizational culture (measured by mission, involvement, consistency, adaptability and well-being), employee organizational commitment and employee innovation in the Vietnamese IT industry.Design/methodology/approachThis is a quantitative research using perceptual scale questionnaire survey developed based on the literature review and in-depth expert interviews. A total of 319 IT professionals working in Vietnam participated in the survey. The data were analyzed using multiple regression analysis.FindingsThe results suggest that overall organizational culture and organizational commitment are positively and significantly related to employee innovation. A closer look reveals that out of the organizational culture’s five dimensions, mission, adaptability and well-being are found specifically and significantly related to employee innovation.Research limitations/implicationsThe study used a cross-sectional survey where case studies of longitudinal study may add more insight. Further, the Denison organizational culture survey instrument might be subjective. Finally, there may be also some moderating or mediating effects that are not taken into account in this study.Practical implicationsThe enhancement of adaptability, well-being, mission and commitment can increase employee innovation in the IT industry.Originality/valueThis paper contributes to the literature and practice by demonstrating the relationship between corporate culture and organizational commitment on employee innovation in a developing country (i.e. Vietnam).
Using hybrid modelling to simulate and analyse strategies
Authors: Gu Yunfei , Kunc Martin 
Published: December 2019

PurposeThis paper aims to explore the applicability and strengths of proposing the three-paradigm hybrid simulation (HS) approach to developing and analysing strategies. The objective of the modelling effort is to conceptually illustrate its use in strategic planning by combining with the threat-opportunity-weakness-strength (TOWS) matrix, which builds a bridge between strategic management with the operations research community. The authors also aim to introduce a modelling framework to help model designers to apply HS to their own business issues.Design/methodology/approachThe paper presents a process to develop a HS model associated with the development of strategies using the TOWS matrix.FindingsAfter developing the model and testing four strategies, the best option for the supermarket to increase market share and sales is implementing the strength–opportunity strategy, which involves online shopping to adapt to the digital world.Research limitations/implicationsFirst, some modelling assumptions are used to simplify the development process, but they need further validation. Second, the real data collection is limited. Third, the personal learning edition of the simulation software is not a comprehensive version and has some limitations.Practical implicationsThe hybrid model and the scenario planning introduced, in this study, could allow decision makers to rehearse the potential strategy before actual implementation. The framework is easy to implement to other business and industry.Originality/valueThis study links HS with strategic management, which has not been performed previously and evaluates the capability of HS in strategic planning. The functionality of the modelling platform has been tested for simulating a completely dynamic system.
Innocent source of humanity
Authors: Goosseff Kyrill 
Published: December 2019

Purpose
To identify the Transcendental Essence of Humanity, the purpose of this paper is to describe in brief what kind of research became possible when the theory of, e.g. autopoiesis, Husserl’s Transcendental Consciousness and the theory of Rhodes and Thame came together to form a “transcendental” interview methodology.

Design/methodology/approach
Critical conceptual implications are drawn to form a new research method to explore a de-subjectified inner domain and to search for a possible common essence of humanity.

Findings
A Transcendental Emotional Reference was found practically alien to contemporary perspectives. Still, the reference governs the emotional structure of human experience. This different perspective answers basic questions of morality, organization theory and leadership.

Research limitations/implications
The findings of the new research open a new and transparent perspective answering Grey’s question: “What is it to be human?” (Grey, p. 47, 2014.) A perspective shedding new light on the humanities. A research limitation is the number of respondents. Still, being transcendental the findings are theoretically valid for all.

Originality/value
The paper is based on a unique research enabling 32+ (ongoing research) respondents to explore their own and universally shared Transcendental domain.
Bringing the individual into the co-creation of value
Authors: Ranjan Kumar Rakesh , Read Stuart 
Published: December 2019

Purpose
Despite the increasing prominence of value co-creation (VCC) in extant research, the area of customer co-creation is in its infancy and many aspects are not well-understood. This paper aims to important work from the individual psychology literature with the concept of VCC and offers empirical evidence to untested theoretical claims regarding the role of the individual in VCC.

Design/methodology/approach
The investigation begins with reviews of the literature of individual psychology and VCC to compare the concepts they use to explain the role of the individual in co-creation. The results of the theoretical development are empirically derived using a multiple vignette-based study to examine relationships between individual characteristics and the activity of VCC.

Findings
The authors find a positive effect of a customer’s prosocial orientation, perspective taking and involvement on VCC. However, a customer’s extraversion does not affect the degree of VCC. The desire-to-participate mediates these relationships.

Research limitations/implications
This study offers a foundation for some of the central claims about VCC and encourages a precise understanding of the impact of individual customer psychology in value co-creation with firms. Implications for the service-dominant logic of marketing and core work in psychology are discussed.

Practical implications
Managers seeking to design co-creative ecosystems need to know about the individuals they are co-creating with. In this research, the authors clearly exemplify how managers can use in practice a theoretical understanding of individuals to better direct the activity of VCC.

Originality/value
This paper provides both new theoretical knowledge from the parallel literature review and exciting empirical results from the authors’ investigation into phenomenological claims regarding VCC.
Fruit and vegetable intake and odds of pediatric migraine
Authors: Ariyanfar Shadi , Razeghi Jahromi Soodeh , Rezaeimanesh Nasim , Togha Mansoureh , Ghorbani Zeinab , Khadem Ebrahim , Ghanaatgar Milad , Noormohammadi Morvarid , Torkan Zahra 
Published: December 2019

Purpose
Diet is recognized as a possible potential factor in migraine pathogenesis. Limited evidence exists on the effect of diet on pediatric migraine, so this paper aims to investigate the association between fruit and vegetable consumption and odds of migraine in children.

Design/methodology/approach
The authors conducted a case-control study in tertiary Sina hospital, Tehran, Iran. A hundred children with migraine as case group and 190 sex-matched healthy controls were included in this study. Definite diagnosis of migraine was based on 2018 international classification of headache disorder 3 (ICHD3) criteria. Demographic and anthropometric characteristics were collected. Common dietary intake of participants was obtained using a validated semi-quantitative food frequency questionnaire.

Findings
Children in the migraine group had significantly higher BMI and age compared with the control group (p-value = <0.01). After adjustment for age, gender, BMI and total energy intake, a significant association between higher intake of vegetables in second tertile (OR: 0.47; CI: 0.24-0.92), fruits in third tertile (OR: 0.31; CI:0.14-0.69) and fiber in fourth quartile (OR:0.28; CI:0.095-0.85) was obtained. Controlling for all confounders in Model 3, the odds of migraine, decreased by 50 per cent and 70 per cent as the consumption of vegetables and fruits increased, in the second tertile of vegetables (p-value = 0.04) and the third tertile of fruits (p-value = <0.01).

Originality/value
The findings confirm a plausible protective role of dietary fruits and vegetables against the risk of migraine in children, which can be attributed to the probable effect of dietary fiber.