bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model-Based Inference and Classification of Immunologic Control Mechanisms from TKI Cessation and Dose Reduction in Patients with CML
Authors: Hähnel Tom , Baldow Christoph , Guilhot Joëlle , Guilhot François , Saussele Susanne , Mustjoki Satu , Jilg Stefanie , Jost Philipp J. , Dulucq Stephanie , Mahon François-Xavier , Roeder Ingo , Fassoni Artur C. , Glauche Ingmar 
Published: February 2020

Abstract

Recent clinical findings in patients with chronic myeloid leukemia (CML) suggest that the risk of molecular recurrence after stopping tyrosine kinase inhibitor (TKI) treatment substantially depends on an individual's leukemia-specific immune response. However, it is still not possible to prospectively identify patients that will remain in treatment-free remission (TFR). Here, we used an ordinary differential equation model for CML, which explicitly includes an antileukemic immunologic effect, and applied it to 21 patients with CML for whom BCR-ABL1/ABL1 time courses had been quantified before and after TKI cessation. Immunologic control was conceptually necessary to explain TFR as observed in about half of the patients. Fitting the model simulations to data, we identified patient-specific parameters and classified patients into three different groups according to their predicted immune system configuration (“immunologic landscapes”). While one class of patients required complete CML eradication to achieve TFR, other patients were able to control residual leukemia levels after treatment cessation. Among them were a third class of patients that maintained TFR only if an optimal balance between leukemia abundance and immunologic activation was achieved before treatment cessation. Model simulations further suggested that changes in the BCR-ABL1 dynamics resulting from TKI dose reduction convey information about the patient-specific immune system and allow prediction of outcome after treatment cessation. This inference of individual immunologic configurations based on treatment alterations can also be applied to other cancer types in which the endogenous immune system supports maintenance therapy, long-term disease control, or even cure.

Significance:
This mathematical modeling approach provides strong evidence that different immunologic configurations in patients with CML determine their response to therapy cessation and that dose reductions can help to prospectively infer different risk groups.
See related commentary by Triche Jr, p. 2083
On the Relationship between the African Easterly Jet, Saharan Mineral Dust Aerosols, and West African Precipitation
Authors: Bercos-Hickey Emily , Nathan Terrence R. , Chen Shu-Hua 
Published: February 2020

AbstractThe relationship between the African easterly jet (AEJ), Saharan mineral dust (SMD) aerosols, and West African precipitation (WAP) is examined using European Centre for Medium-Range Weather Forecasts interim reanalysis (ERA-Interim) data, the NASA Modern-Era Retrospective Analysis for Research and Applications, version 2 (MERRA-2), and the NASA Tropical Rainfall Measuring Mission (TRMM) Multisatellite Precipitation Analysis (TMPA) for July–September 1998–2017. The spatial orientation and structure of AEJs in different SMD–WAP environments are compared. In dustier years, the AEJ is farther east and stronger, rotates clockwise, and has larger zonal and vertical shears. In wetter years, the AEJ is farther north, has a shorter zonal extent, and has larger meridional shear. These changes to the AEJ are a response to the combined effects of the SMD and WAP on the thermal field, which is confirmed through sensitivity tests carried out with the Weather Research and Forecasting Model coupled to an interactive dust model.
Identifying the Sources of Continental Summertime Temperature Variance Using a Diagnostic Model of Land–Atmosphere Interactions
Authors: Zeppetello L. R. Vargas , Tétreault-Pinard Étienne , Battisti D. S. , Baker M. B. 
Published: February 2020

AbstractClimate models show that soil moisture and its subseasonal fluctuations have important impacts on the surface latent heat flux, thus regulating surface temperature variations. Using correlations between monthly anomalies in net absorbed radiative fluxes, precipitation, 2-m air temperature, and soil moisture in the ERA-Interim reanalysis and the HadCM3 climate model, we develop a linear diagnostic model to quantify the major effects of land–atmosphere interactions on summertime surface temperature variability. The spatial patterns in 2-m air temperature and soil moisture variance from the diagnostic model are consistent with those from the products from which it was derived, although the diagnostic model generally underpredicts soil moisture variance. We use the diagnostic model to quantify the impact of soil moisture, shortwave radiation, and precipitation anomalies on temperature variance in wet and dry regions. Consistent with other studies, we find that fluctuations in soil moisture amplify temperature variance in dry regions through their impact on latent heat flux, whereas in wet regions temperature variability is muted because of high mean evapotranspiration rates afforded by plentiful surface soil moisture. We demonstrate how the diagnostic model can be used to identify sources of temperature variance bias in climate models.
On the Emergence of the Atlantic Multidecadal SST Signal: A Key Role of the Mixed Layer Depth Variability Driven by North Atlantic Oscillation
Authors: Yamamoto Ayako , Tatebe Hiroaki , Nonaka Masami 
Published: February 2020

AbstractDespite its wide-ranging potential impacts, the exact cause of the Atlantic multidecadal oscillation/variability (AMO/AMV) is far from settled. While the emergence of the AMO sea surface temperature (SST) pattern has been conventionally attributed to the ocean heat transport, a recent study showed that the atmospheric stochastic forcing is sufficient. In this study, we resolve this conundrum by partitioning the multidecadal SST tendency into a part caused by surface heat fluxes and another by ocean dynamics, using a preindustrial control simulation of a state-of-the-art coupled climate model. In the model, horizontal ocean heat advection primarily acts to warm the subpolar SST as in previous studies; however, when the vertical component is also considered, the ocean dynamics overall acts to cool the region. Alternatively, the heat flux term is primarily responsible for the subpolar North Atlantic SST warming, although the associated surface heat flux anomalies are upward as observed. Further decomposition of the heat flux term reveals that it is the mixed layer depth (MLD) deepening that makes the ocean less susceptible for cooling, thus leading to relative warming by increasing the ocean heat capacity. This role of the MLD variability in the AMO signature had not been addressed in previous studies. The MLD variability is primarily induced by the anomalous salinity transport by the Gulf Stream modulated by the multidecadal North Atlantic Oscillation, with turbulent fluxes playing a secondary role. Thus, depending on how we interpret the MLD variability, our results support the two previously suggested frameworks, yet slightly modifying the previous notions.
Evaluation of the Grell–Freitas Convective Scheme in the Hurricane Weather Research and Forecasting (HWRF) Model
Authors: Biswas Mrinal K. , Zhang Jun A. , Grell Evelyn , Kalina Evan , Newman Kathryn , Bernardet Ligia , Carson Laurie , Frimel James , Grell Georg 
Published: February 2020

Abstract
The Developmental Testbed Center (DTC) tested two convective parameterization schemes in the Hurricane Weather Research and Forecasting (HWRF) Model and compared them in terms of performance of forecasting tropical cyclones (TCs). Several TC forecasts were conducted with the scale-aware Simplified Arakawa Schubert (SAS) and Grell–Freitas (GF) convective schemes over the Atlantic basin. For this sample of over 100 cases, the storm track and intensity forecasts were superior for the GF scheme compared to SAS. A case study showed improved storm structure for GF when compared with radar observations. The GF run had increased inflow in the boundary layer, which resulted in higher angular momentum. An angular momentum budget analysis shows that the difference in the contribution of the eddy transport to the total angular momentum tendency is small between the two forecasts. The main difference is in the mean transport term, especially in the boundary layer. The temperature tendencies indicate higher contribution from the microphysics and cumulus heating above the boundary layer in the GF run. A temperature budget analysis indicated that both the temperature advection and diabatic heating were the dominant terms and they were larger near the storm center in the GF run than in the SAS run. The above results support the superior performance of the GF scheme for TC intensity forecast.
Effect of Laryngeal Suspension and Upper Esophageal Sphincter Myotomy for Severe Dysphagia Due to Brainstem Disease
Authors: Shibata Seiko , Kagaya Hitoshi , Ozeki Yasunori , Saitoh Eiichi , Aoyagi Yoichiro , Iwata Yoshihiro , Sakurai Kazuo 
Published: February 2020

Objectives: Surgical procedure is considered in patients with severe dysphagia when conservative treatment fails. This study aimed to evaluate laryngeal suspension (LS) and upper esophageal sphincter (UES) myotomy for treating severe dysphagia due to brain disease. Methods: Fourteen patients underwent LS and UES myotomy, with a median follow-up of 5 years and 6 months when conservative treatment failed. The penetration-aspiration scale (PAS), the Dysphagia Severity Scale (DSS), the Eating Status Scale (ESS), and diet contents were evaluated just before surgery, at discharge, and at the last follow-up. Results: Preoperative intake was tube feeding in all patients. The patients learned the extended head and flexed neck posture to open the esophageal inlet. PAS, DSS and ESS scores, and diet contents were significantly improved at discharge compared with before surgery, and were maintained until the last follow-up. Eight patients had pneumonia during their hospital stay, and five had pneumonia between discharge and at the last follow-up. Age was significantly, negatively correlated with DSS and ESS at the last follow-up. Conclusion: Although LS and UES myotomy require a long inpatient rehabilitation and the risk of pneumonia after surgery is high, the outcome is favorable and the effects last for a long time.
Using a 4K-3D Exoscope for Upper Airway Stimulation Surgery: Proof-of-Concept
Authors: Patel Vijay A. , Goyal Neerav 
Published: February 2020

Objective: Demonstrate the potential of the 4K-3D exoscope during upper airway stimulation surgery (UAS). Methods: A proof-of-concept study was performed to evaluate the feasibility of the exoscope during three consecutive UAS. Results: The exoscope was employed during UAS including cuff electrode and sensing lead placement. Three cases were successfully completed without adverse perioperative event; mean operative time was 200 minutes (range 188-218 minutes) with a successive reduction in operative time. Conclusion: This experience demonstrates the potential viability of the exoscope for UAS; it is a safe, innovative, and effective alternative or adjunct to existing visualization modalities. Notable advantages include improved ergonomics, unobstructed surgical field access, wide depth of field visualization, and short learning curve. Future technological enhancements could allow the exoscope to become a promising next-generation tool in the armamentarium of the contemporary sleep surgeon.
Age- and Sex-Related Differences in Nonfatal Dog Bite Injuries Among Persons Aged 0-19 Treated in Hospital Emergency Departments, United States, 2001-2017
Authors: Basco Adelaide Newman , McCormack Emma Reiss , Basco William T. 
Published: February 2020

Objective: No studies using national data have evaluated changes in nonfatal dog bite injuries among children, adolescents, and young adults during the past 2 decades. We examined estimates of annual nonfatal dog bite injuries among persons aged 0-19 treated in US emergency departments (EDs) from 2001 through 2017. Methods: We examined data from the Web-based Injury Statistics Query and Reporting System to compare estimates of the annual rates of nonfatal dog bite injuries in EDs among all persons aged 0-19, by age group (0-4, 5-9, 10-14, and 15-19), and by sex. We determined significance by comparing 95% confidence intervals (CIs), and we standardized rate calculations to the year 2000 population. Results: During 2001-2017, an estimated 2 406 109 (95% CI, 2 102 643-2 709 573) persons aged 0-19 were treated in EDs for nonfatal dog bite injuries (age-adjusted rate of 173.1 per 100 000 persons aged 0-19). The estimated number of nonfatal dog bite injuries declined significantly, from 181 090 (95% CI, 158 315-203 864) in 2001 to 118 800 (95% CI, 97 933-139 667) in 2017. The highest rate was among children aged 5-9. Male children, adolescents, and young adults were significantly more likely than female children, adolescents, and young adults to be treated in the ED for nonfatal dog bite injuries, driven by male–female differences in children and adolescents aged 5-14. Conclusions: Although the estimated number of nonfatal dog bite injuries among persons aged 0-19 declined significantly in the past 2 decades, additional regulatory and educational efforts specific to age and sex may lead to further reductions in nonfatal dog bite injuries.
Employed Vocational Rehabilitation Applicants with Visual Disabilities: Factors Associated with Timely Service Delivery
Authors: Crudden Adele , Sui Zhen , Lund Emily 
Published: February 2020

Introduction: Employed applicants for vocational rehabilitation need timely services to improve the likelihood of their successful job retention or career advancement. Little research exists that examines timeliness of services among employed applicants, particularly for applicants with visual disabilities. This study investigated time from vocational rehabilitation application to a signed Individualized Plan for Emplolyment (IPE) for employed applicants with visual disabilities. Method: The sample of 5,096 competitively employed vocational rehabilitation applicants from the FY2015 RSA-911 report was combined with survey responses from 51 vocational rehabilitation agencies about services to persons with visual disabilities. Multilevel modeling was used to examine effects of state-level and individual-level characteristics and cross-level interactions on the length of waiting time from vocational rehabilitation application to signed IPE. Results: The time from application to IPE was shorter for employed applicants with visual disabilities who received services from separate vocational rehabilitation agencies compared to that of combined vocational rehabilitation agencies. Employed vocational rehabilitation applicants with visual disabilities waited longer if they were younger, non-White, or received disability benefits. Official job-retention policies in state vocational rehabilitation agencies appeared to reduce the delay of IPE implementation for persons with secondary disabilities, for applicants who received disability benefits, and for persons who worked more hours per week. Discussion: Additional research to determine how vocational rehabilitation can provide services to employed persons as soon as possible after application is indicated, particularly for persons applying to combined agencies. Implications for practitioners: Vocational rehabilitation providers should explore ways to expedite service delivery, particularly for persons who are younger, non-White, or receiving disability benefits. Implementing official vocational rehabilitation policies for addressing job-retention and career-advancement cases may be one avenue to expedite services to some employed applicants.
An Exploratory Study of General Self-Efficacy and Employment in Adults with Retinitis Pigmentosa
Authors: Zapata Mercedes A. 
Published: February 2020

Introduction: In this study, the author examined the association between general self-efficacy (GSE) and employment status in working-age adults with retinitis pigmentosa (RP; N = 183). The author further examined the associations between employment status and factors that were previously found to be linked to employment outcomes in individuals with visual impairments: educational attainment, mobility tool use (i.e., use of dog guide or cane), ability to drive, age, gender, and age at onset of visual impairment. Methods: Multiple logistic regression was used to analyze cross-sectional data collected online in 2015. Results: Findings indicated that individuals with RP who have a bachelor’s degree or higher had significantly higher odds of being employed ( p < .01) and that individuals with RP who use a cane or dog guide had significantly lower odds of being employed ( p < .01). Although not statistically significant, findings further indicated that individuals with RP who have higher GSE had higher odds of being employed ( p = .07) and that individuals who are able to drive had 130% higher odds of being employed ( p = .06). Discussion: Results demonstrated an association between GSE and employment status, after controlling for factors that were previously linked to employment outcomes in individuals with visual impairment. Implications for practitioners: Self-efficacy is an alterable cognitive construct and may be the target of interventions to increase employment outcomes for adults with RP or other eye conditions.
Overview of Vocational Rehabilitation Data about People with Visual Impairments: Demographics, Services, and Long-Run Labor Market Trends
Authors: Clapp Christopher M. , Pepper John V. , Schmidt Robert , Stern Steven 
Published: February 2020

Introduction: This study describes the characteristics of, services received by, and labor market outcomes of applicants with visual impairments to three state vocational rehabilitation programs. Our objective is to both document cross-state variation in vocational rehabilitation clientele and services and provide new insights on the longitudinal labor market outcomes of clients with visual impairments (i.e., blindness or low vision). This analysis is a first step in assessing the returns to vocational rehabilitation services for this population. Methods: We first created a unique longitudinal data set by matching administrative records on applicants who are visually impaired in state fiscal year 2007 from three vocational rehabilitation agencies to 8 years of employment data from state Unemployment Insurance programs. Using these data, we examined cross-state variation in the descriptive statistics for important client explanatory variables and vocational rehabilitation service categories. We then compared the long-term labor market outcomes of clients receiving services (treated) to untreated individuals. Results: We documented two important findings. First, there were substantial differences in client characteristics, services provided, and costs across the three states. Second, the long-run labor market analysis was consistent with vocational rehabilitation services having no employment effect but a positive earnings effect. Discussion: Labor market results indicate vocational rehabilitation services provided persistent earnings benefits. Yet the substantial cross-state heterogeneity suggests these labor market results might not be generalizable and should be interpreted with caution. We explain what was missing from this analysis and why the results should not be thought of as causal. Implications for Practitioners: This article gives practitioners a sense of a unique new data set on vocational rehabilitation and labor market variables for applicants with visual impairments. We highlight the importance of cross-state variation and linking vocational rehabilitation data to long-term employment measures. The question of how best to inform the efficacy of different vocational rehabilitation strategies for clients with visual impairments is left for future researchers to consider.
What is rehabilitation? An empirical investigation leading to an evidence-based description
Authors: Wade Derick T 
Published: February 2020

Background: There is no agreement about or understanding of what rehabilitation is; those who pay for it, those who provide it, and those who receive it all have different interpretations. Furthermore, within each group, there will be a variety of opinions. Definitions based on authority or on theory also vary and do not give a clear description of what someone buying, providing, or receiving rehabilitation can actually expect. Method: This editorial extracts information from systematic reviews that find rehabilitation to be effective, to discover the key features and to develop an empirical definition. Findings: The evidence shows that rehabilitation may benefit any person with a long-lasting disability, arising from any cause, may do so at any stage of the illness, at any age, and may be delivered in any setting. Effective rehabilitation depends on an expert multidisciplinary team, working within the biopsychosocial model of illness and working collaboratively towards agreed goals. The effective general interventions include exercise, practice of tasks, education of and self-management by the patient, and psychosocial support. In addition, a huge range of other interventions may be needed, making rehabilitation an extremely complex process; specific actions must be tailored to the needs, goals, and wishes of the individual patient, but the consequences of any action are unpredictable and may not even be those anticipated. Conclusion: Effective rehabilitation is a person-centred process, with treatment tailored to the individual patient’s needs and, importantly, personalized monitoring of changes associated with intervention, with further changes in goals and actions if needed.
Comparative study of the Ambu® AuraOnce™ laryngeal mask and endotracheal intubation in anesthesia airway management during neurosurgery
Authors: Zhang Qiaoyun , Sun Yongxing , Wang Baoguo , Wang Shuangyan , Mu Feng , Zhang Yunxin 
Published: February 2020

Objective To investigate the feasibility and efficacy of the Ambu® AuraOnce™ laryngeal mask (LMA) compared with endotracheal intubation (ETI) during supratentorial tumor resection in the right lateral decubitus position. Methods This was a randomized controlled trial of LMA compared with ETI in patients who were scheduled to undergo supratentorial tumor resection in the right lateral decubitus position. The patients were randomized to the LMA (n = 40) and ETI groups (n = 40). The hemodynamic parameters (primary outcome) and mechanical ventilation parameters, anesthetic dose, and complications as well as quality of anesthesia recovery (secondary outcomes) were compared. Results Patients in the LMA group exhibited lower mean arterial pressure (MAP) and heart rate (HR) compared with ETI. Nine and two patients received esmolol during intubation and extubation, respectively. The airway pressure (AP) in the LMA group was higher compared with the ETI group 60 minutes after the start of surgery. Compared with the ETI group, the sufentanil dose was lower by 24% and the anesthesia recovery rate was better in the LMA group. Conclusions LMA can improve hemodynamic stability in patients undergoing supratentorial tumor resection in the right lateral decubitus position. If there is a clinical need and no contraindication, LMA could replace ETI.