bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor exosomal RNPEP promotes lung metastasis of liver cancer via inducing cancer‐associated fibroblast activation
Authors: Chen Yuankun , Pan Gaofeng , Yang Yijun , Wu Haifeng , Weng Minhua , Wu Qiuping , Gao Yufeng , Li Wenting 
Published: December 2024

AbstractCancer‐associated fibroblasts (CAFs) are essential players in the tumor microenvironment (TME) due to their roles in facilitating tumor progression and metastasis. It is worth noting that the high‐metastatic hepatocellular carcinoma (HCC) cell‐derived exosomes have exhibited the ability to transform normal fibroblasts into CAFs, which further fosters the lung metastasis of low‐metastatic HCC cells. Yet, the mechanisms underlying this tumor exosome‐induced metastatic niche formation are poorly explored. In this study, the secreted protein arginyl aminopeptidase (RNPEP) was highly expressed in the plasma of patients with HCC. In addition, high‐metastatic HCC cells showed augmented RNPEP expression levels in their exosomes. These exosomes induced obvious CAF‐like properties in the human fibroblast cell line MRC‐5, as evidenced by the increased CAF marker expression, and enhanced migratory ability. More strikingly, the secretions from high‐metastatic tumor exosome‐educated MRC‐5 cells increased tumor stemness and promoted epithelial–mesenchymal transition (EMT) in MHCC‐97L cells, a low‐metastatic HCC cell line. However, the knockdown of RNPEP in exosomes from high‐metastatic HCC cells abated the changes described above. Animal studies in vivo highlighted the pro‐tumor and pro‐metastatic effects of exosomal RNPEP on MHCC‐97L cells by inducing CAF activation. Furthermore, tumor‐derived exosomal RNPEP induced the activation of NF‐κB signaling in MRC‐5 cells, a critical pathway associated with CAF activation. Collectively, these results provide novel insight into tumor‐derived exosomal RNPEP for its crosstalk with CAFs during HCC lung metastasis.
Use of Freestyle Libre 2.0 in children with type 1 diabetes mellitus and elevated HbA1c: Extension phase results after a 12‐week randomized controlled trial
Authors: Zhou Yongwen , Wheeler Benjamin J. , Boucsein Alisa , Styles Sara E. , Chamberlain Bronte , Michaels Venus R. , Crockett Hamish R. , Lala Anita , Cunningham Vicki , Wiltshire Esko J. , Serlachius Anna S. , Jefferies Craig 
Published: December 2024

AbstractAimTo investigate extension phase outcomes with intermittently scanned continuous glucose monitoring (isCGM 2.0) in children with type 1 diabetes mellitus (T1DM) and elevated HbA1c (7.5–12.2% [58–110 mmol/mol]).MethodsOne hundred children with T1DM aged 4–13 years were initially in a 12‐week randomised controlled trial (RCT) comparing glycaemic outcomes with isCGM 2.0 (intervention group, n = 49) with self‐monitored blood glucose (Control group, n = 51). After the 12‐week RCT both groups were offered an extension phase with isCGM 2.0 for another 12 weeks. HbA1c, CGM metrics, psychological outcomes and device utilization attitudes were measured.ResultsAfter the initial 12‐week RCT, 66 participants completed this 12‐week extension: 36/49 (73%) and 30/51 (58.8%) from the isCGM/isCGM and Control/isCGM groups, respectively. In the isCGM/isCGM group, time below range 70 mg/dL (3.9 mmol/L) (TBR70) reduced from 10.7 ± 11.3% at baseline to 2.8 ± 2.8% and 2.1 ± 2.4% at 12 and 24 weeks, respectively (p < 0.01 for both 12 and 24 weeks). Glucose test frequency increased from 4.7 (2.7) at baseline to 10.7 (4.6) and 9.2 (4.7) at 12 and 24 weeks, respectively (p < 0.01 for both 12 and 24 weeks). The Control/isCGM group decreased TBR70 from 10.7 ± 7.4% at 12 weeks to 2.9 ± 2.8% at 24 weeks and increased daily glucose test frequency from 3.2 (1.6) to 10.7 (5.4) from 12 to 24 weeks (both p < 0.01). However, HbA1c and time in range (TIR) were non‐significant at 24 weeks in both groups.ConclusionsExtension phase outcomes with intermittently scanned continuous glucose monitoring (isCGM 2.0) in children with T1DM and elevated HbA1c showed a sustained reduction in hypoglycaemia and increased testing frequency at 24 weeks.
Differentiating the Role of Growth Language Mindsets in Feedback‐Seeking Behaviour in L2 Writing through Perspective‐Taking: A Mixed‐Method Study
Authors: Xu Jian , Wang Yabing , Peng Bo 
Published: December 2024

ABSTRACTThe differential impact of growth language mindsets on second or foreign (L2) writing feedback‐seeking behaviour (FSB) is an important yet underexplored area of research. How perspective‐taking, a less‐researched construct in L2 writing, directly predicts FSB or mediates the paths between growth language mindsets and FSB remains unknown, either. Therefore, the present mixed‐method study seeks to explore the impacts of growth language mindsets—specifically related to intelligence, aptitude and age sensitivity—perspective‐taking on FSB, and particularly examines whether perspective‐taking mediates the relationship between growth language mindsets and FSB. A battery of questionnaires were administered to 571 Chinese learners of English at the tertiary level, of whom six L2 learners were interviewed. Quantitative results showed that growth mindsets on language aptitude and age sensitivity as well as perspective‐taking positively predicted both feedback monitoring and feedback inquiry; growth mindsets on language intelligence only predicted feedback inquiry. Perspective‐taking mediated the relationship between growth mindsets on language aptitude and both feedback monitoring and feedback inquiry. The qualitative findings highlighted the influences of growth language mindsets and perspective‐taking on FSB, with the latter moderated by learning goals and types of writing tasks. This study provides implications for improving L2 learners' growth language mindsets and perspective‐taking abilities.
Media coverage and the cost of equity capital around the world
Authors: Gao Xin , Li Donghui , Xing Lu , Xu Weidong 
Published: December 2024

AbstractUsing a sample of 38 countries, our study is the first to show on a global scale that the relation between media coverage and implied cost of equity capital (ICOC) is negative and both statistically and economically significant. On average, a one‐unit increase in media coverage (approximately two news articles) leads to a 0.38% decrease in ICOC. This effect hinges on the degree of press freedom in the reporting country and the credibility of specific media outlets. The effect is more pronounced in countries with less developed capital markets but greater US media penetration. Furthermore, firms with higher information asymmetry or weaker corporate governance experience a stronger impact of media coverage on ICOC. Positive news coverage encourages firms to invest more and use less debt, while negative news coverage has opposite influences. Finally, the release of media news is associated with reduced option‐implied volatility.
Nutrition, Chewing Ability and Quality of Life in Older Adults With Implant Overdentures: A Prospective Clinical Study
Authors: Küçük Ceren , Sabuncular Güleren , Bayram Ferit , Aktaç Şule , Evren Buket , Güneş Fatma Esra 
Published: December 2024

ABSTRACTObjectivesTo evaluate the changes in nutritional status, chewing ability and oral health‐related quality of life in edentulous individuals who have initially been rehabilitated with immediate complete dentures (CD) which are then transformed to implant‐supported overdentures (IOD) after a period of osseointegration.BackgroundCompared to those with conventional dentures, individuals with IODs exhibit improved patient‐reported outcomes, chewing capacity and biting force. While prior research highlights differences in nutritional markers between these groups, there is limited investigation into intra‐individual changes in nutritional status, chewing ability and oral health‐related quality of life during the transition from CDs to IODs.Materials and MethodsEdentulous individuals aged 50 years or older and needing oral rehabilitation with IODs were eligible for this prospective study. The primary outcome measure was the nutritional status as measured by the Mini Nutritional Assessment (MNA). The Oral Health Impact Profile (OHIP‐14) questionnaire and chewing ability questionnaire represented secondary outcome measures. These measures were assessed at baseline (T0), 3‐month follow‐up after application of the CD (T1), and 3‐ and 6‐month follow‐up after the CD had been transformed to IOD (T2 and T3). Statistical analyses used repeated measures ANOVA or the Friedman test for OHIP‐14 and MNA scores, with logistic regression used for malnutrition risk.ResultsThirty‐five participants were included in the final analysis. MNA scores significantly worsened from the baseline to the 3‐month follow‐up after the application of the CD. There was no significant change in nutritional status between baseline and the IOD 3‐ and 6‐month follow‐up appointment. IODs led to significant improvements in the OHIP total score at both the 3‐ and 6‐month follow‐ups (p < 0.001, W = 0.60) with a strong effect size. Difficulty in chewing decreased significantly, affecting 91.4% of participants at baseline, which reduced to 51.4% (18/35) by the 6th month.ConclusionImplant‐supported overdentures do not influence nutritional status, but they improve chewing ability and oral–health related quality of life in older adults.
Modeling the Influence of Coastal Site Characteristics on PFAS in Situ Remediation
Authors: Carey Grant R. , Danko Anthony , Pham Anh Le‐Tuan , Soderberg Keir , Hoagland Beth , Sleep Brent 
Published: December 2024

AbstractThe potential performance of a hypothetical colloidal‐activated carbon (CAC) in situ remedy for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) in groundwater in coastal zones was evaluated using estimated hydrogeologic and geochemical parameters for a coastal site in the United States. With these parameters, a reactive transport model (ISR‐MT3DMS) was used to assess the effects of tidal fluctuations and near‐shore geochemistry on CAC performance. The average near‐shore ionic strength of 84 mM at the site was conservatively estimated to result in an increase in the adsorption of PFOA to CAC by about 50% relative to non‐coastal sites with ionic strength <10 mM. The modeling also confirmed the hypothesis that tidally induced groundwater flow reversals near the shore would result in the accumulation of PFOA at the downgradient edge of the CAC zone. Slow desorption of PFOA from this downgradient CAC boundary may sustain downgradient plume concentrations above a strict cleanup criterion (e.g., USEPA MCL of 0.004 μg/L), for decades; however, there was still a large PFOA mass flux reduction (>99.9%) achieved after several decades at the shore. CAC longevity was substantially greater for PFOS with a similar source concentration; however, the higher PFOS distribution coefficient (Kd) in soil downgradient from the CAC zone resulted in substantially longer flushing times. It is recommended that short‐term remedial action objectives for CAC remedies at coastal sites be based on mass flux reduction targets over a period of several decades, given the demonstrated challenges in trying to achieve very low cleanup criteria downgradient of a CAC zone in the short term.
Involving Patients in Hospital‐Based Health Technology Assessment of Innovative Medical Devices: Adapting to a Specific Local Context and Lessons Learned From the Assessment of an Ex Vivo Perfusion System of Human Donor Hearts
Authors: Atfeh Jamal , Guerre Pascale , Berkesse Alexandre , Thual Gwenaëlle , Pozzi Matteo , Huot Laure 
Published: December 2024

ABSTRACTIntroductionA demand from the cardiac surgery and heart transplantation department of a French (Lyon) university hospital to adopt an ex‐vivo perfusion system of human donor hearts was a chance to actively involve patients in our hospital‐based health technology assessment (HB‐HTA) process.Material and MethodsWe selected an existing framework for patient involvement in HB‐HTA and involved patients at two stages of the HB‐HTA process: evaluation and dissemination. Firstly, we conducted a consultation‐oriented workshop to gather patient perspectives on the introduction of the technology in our hospital, based on their significant experience of healthcare. Secondly, we organized an information‐oriented workshop to communicate the HB‐HTA results to the patients consulted, after the decision had been taken.ResultsWe modified the framework for patient involvement to suit the local decision‐making context, the HB‐HTA methodology, and the type of technologies assessed in our institution. Patients perceived the ex‐vivo perfusion system as a promising technology to facilitate access to heart transplantation. They emphasized the importance of a tailored information provided to patients about the potential use of the technology in their healthcare trajectories, and suggested involvement of patients to facilitate its implementation in hospitals.DiscussionModifying existing frameworks for patient involvement to fit specific local contexts should be encouraged, and has to address the need of timely information for decision‐makers and patient recruitment issues. Decision to incorporate patient perspectives and experiences should be made on a project‐by‐project basis, and focus on innovative medical devices with expected significant impact on patient quality of life. Effective and transparent communication and prospective feedbacks from HB‐HTA producers to patients are essential for a successful process.Patient or Public ContributionThree patients with a lived experience of heart transplantation, or another transplant procedure, or more broadly procedures involving innovative medical devices (specialists) and two patients recruited for societal issues and legitimacy of a collective voice were involved (generalists).
Side Effects of Psychotropic Medications Experienced by a Community Sample of People Living With Severe and Persistent Mental Illness
Authors: Collins Jack C. , Wheeler Amanda J. , McMillan Sara S. , Hu Jie , El‐Den Sarira , Roennfeldt Helena , O'Reilly Claire L. 
Published: December 2024

ABSTRACTBackgroundPsychotropic medications are a common treatment modality for people living with severe and persistent mental illness (SPMI). While effective in reducing relapse and hospitalisation, psychotropic medications cause numerous side effects, varying in nature and severity. Identification and management of side effects is crucial in the ongoing management of SPMI.ObjectiveTo characterise the side effects of psychotropic medications, experienced by a sample of consumers living with SPMI, using a validated tool.Setting and ParticipantsConsumers with SPMI living in the community were recruited from all 25 community pharmacies across four Australian regions, which were allocated to the intervention arm of the Bridging the Gap between Physical and Mental Illness (PharMIbridge) randomised controlled trial (RCT).Main Outcome MeasuresResponses to the My Medicines & Me Questionnaire (M3Q).ResultsConsumers (n = 156) most frequently reported side effects in the categories of sleep‐related side effects (80.8%, n = 126), mood‐related side effects (75.6%, n = 118) and weight and appetite changes (60.3%, n = 107). Daytime somnolence was the most reported individual side effect (68.6%, n = 107). Mood‐related side effects were ranked as the most bothersome, followed by sleep‐related side effects and weight and appetite changes. More than one‐quarter (29.5%, n = 46) of consumers reported choosing not to take their medications due to side effects. Consumers more frequently told family and friends about the side effects rather than healthcare professionals.ConclusionsAn overwhelming majority of consumers experienced at least one side effect attributed to their psychotropic medication, with many experiencing multiple. These findings highlight the critical need to regularly engage with consumers to discuss, identify and manage side effects to treatment burden, reduce risk of non‐adherence and improve their treatment experience.Patient or Public ContributionThe PharMIbridge RCT included a training programme and intervention service that was co‐designed and co‐delivered with people with lived experience of mental illness. The research team, expert advisory panel and mentors who supported the delivery and implementation of the training and intervention included participants who have lived experience of mental illness or caring for someone with mental illness.Trial RegistrationANZCTR12620000577910.
Thrombin Generation Assay to Support Hematologists in the Era of New Hemophilia Therapies
Authors: Josset Laurie , Rezigue Hamdi , Dargaud Yesim 
Published: December 2024

ABSTRACTHematology laboratories have traditionally monitored hemophilia replacement therapy by measuring coagulation factors before and after infusion. However, new drugs that do not rely on the replacement of the deficient factor require new approaches to laboratory monitoring, as factor VIII (FVIII) or factor IX (FIX) assays are no longer adequate. Non‐factor therapies come in many different forms, that have one thing in common: they all increase thrombin generation. Their main adverse effect is thrombosis which may occur when too much thrombin is formed. This is the perfect mirror image of anticoagulant treatment, which always diminishes the amount of thrombin formed and has bleeding as its main adverse effect. Thrombin‐forming capacity is decreased in congenital bleeding disorders and increased in prothrombotic conditions, indicating it governs bleeding and thrombosis. Therefore, the thrombin generation assay (TGA) is a logical tool for monitoring non‐factor therapies, offering a comprehensive assessment of hemostatic balance. TGA identifies patients with severe bleeding, helps to optimize bypassing therapy, and detects hypercoagulability, making it ideal for guiding and monitoring hemophilia treatment with non‐factor therapies. It also assesses the efficacy and safety of combined therapies, including non‐factor therapies with bypassing agents or FVIII/FIX concentrates. The purpose of this paper is to review the current state of knowledge regarding the use of TGA to monitor novel hemophilia therapies. It will address controversies, limitations, and knowledge gaps related to the integration of TGA into personalized medicine in routine clinical practice.
Do Unexpected Earnings of Industry Leaders Affect the Discretionary Reporting Behavior of Followers? Evidence From China
Authors: Cong Huiyun , Li Dan , Li Xiao , Xie Yuan , Yuan Chun 
Published: December 2024

ABSTRACTThis study examines how the unexpected earnings of industry leaders influence the discretionary reporting behavior of industry followers. Chinese firms are required to disclose their annual earnings announcement (EA) dates before the fiscal year ends. Leveraging this unique setting, we demonstrate that followers delay their EAs in response to earnings surprises reported by industry leaders. This effect is more pronounced for followers who face lower costs of delaying (i.e., those with weak corporate governance and who face no penalties for delaying EAs) and those who receive greater benefits from delaying (i.e., those in more competitive industries and in industries where leaders meet or beat market expectations). We also find that, compared with other followers, those that delay EAs are more likely to engage in last‐minute earnings management by reducing their effective tax rates. Furthermore, our findings suggest that when industry leaders report good news, followers who delay EAs are more likely to do the same. However, we find no positive market reaction to these delayed EAs. Overall, this study provides new evidence that industry leaders’ earnings surprises significantly impact their followers’ decisions about discretionary financial reporting, including the delay of EAs and last‐minute earnings management.
The theragnostic advances of exosomes in managing leukaemia
Authors: Ghosh Subhrojyoti , Dey Anuvab , Chakrabarti Aneshwa , Bhuniya Tiyasa , Indu Neelparna , Hait Anirban , Chowdhury Ankita , Paul Aritra , Mahajan Atharva A. , Papadakis Marios , Alexiou Athanasios , Jha Saurabh Kumar 
Published: December 2024

AbstractLeukaemia, a group of haematological malignancies, presents ongoing diagnosis, prognosis, and treatment challenges. A major obstacle in treating this disease is the development of drug resistance. Overcoming drug resistance poses a significant barrier to effective leukaemia treatment. The emergence of exosome research has unveiled new insights into the probable theragnostic implementations in leukaemia. Various research has exhibited the diagnostic possibilities of exosomes in identifying leukaemia‐specific biomarkers, including genetic mutations and fusion transcripts. Additionally, exosomes have been implicated in disease progression and treatment response, rendering them appealing targets for therapeutics. Exosomes, originating from diverse cell types, are instrumental in intercellular communication as they participate in the functional transportation of molecules like proteins, nucleic acids and lipids across space. Exosomes have a dual role in immune regulation, mediating immune suppression and modulating anti‐leukaemia immune responses. Interestingly, exosomes can even act as drug transport vehicles. This review delves into the intricate process of exosome biogenesis, shedding light on their formation and release from donor cells. The key mechanisms engaged in exosome biogenesis, for instance, the endosomal sorting complexes required for transport (ESCRT) machinery and ESCRT‐independent pathways, are thoroughly discussed. Looking ahead, future approaches that leverage innovative technologies hold the promise of revolutionizing disease management and improving patient outcomes.
Matching Versus Raffles as a Fund‐Raising Device
Authors: Pecorino Paul 
Published: December 2024

ABSTRACTMatching is a commonly used fund‐raising tactic, whereby small donors have their donation to a charity matched via a fund established by large donors. I developed a model in which a single large donor decides whether to establish a matching fund or contribute to the public good via the voluntary contributions mechanism (VCM). The credibility of the matching fund is an endogenous component of the model. For a match to be credible, the organizer must have a credible promise not to top up the contributions of the small donors. If the number of small donors is sufficiently large, there always exists a matching fund that is both credible and leads to a Pareto improvement relative to the VCM. When the matching fund needs to satisfy an endogenous credibility constraint, all of the outcomes that are eliminated due to this constraint are outcomes under which small donors are worse off relative to the VCM. The matching fund is also compared with a raffle mechanism. As the number of small donors grows large, public good provision under the two mechanisms converges. However, the matching function outperforms the raffle when there is a finite number of small donors.