bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome
Authors: Okur Mustafa N. , Mao Beatrice , Kimura Risako , Haraczy Scott , Fitzgerald Tracy , Edwards-Hollingsworth Kamren , Tian Jane , Osmani Wasif , Croteau Deborah L. , Kelley Matthew W. , Bohr Vilhelm A. 
Published: January 2020

AbstractAge-related hearing loss (ARHL) is one of the most common disorders affecting elderly individuals. There is an urgent need for effective preventive measures for ARHL because none are currently available. Cockayne syndrome (CS) is a premature aging disease that presents with progressive hearing loss at a young age, but is otherwise similar to ARHL. There are two human genetic complementation groups of CS, A and B. While the clinical phenotypes in patients are similar, the proteins have very diverse functions, and insight into their convergence is of great interest. Here, we use mouse models for CS (CSA−/− and CSBm/m) that recapitulate the hearing loss in human CS patients. We previously showed that NAD+, a key metabolite with various essential functions, is reduced in CS and associated with multiple CS phenotypes. In this study, we report that NAD+ levels are reduced in the cochlea of CSBm/m mice and that short-term treatment (10 days) with the NAD+ precursor nicotinamide riboside (NR), prevents hearing loss, restores outer hair cell loss, and improves cochlear health in CSBm/m mice. Similar, but more modest effects were observed in CSA−/− mice. Remarkably, we observed a reduction in synaptic ribbon counts in the presynaptic zones of inner hair cells in both CSA−/− and CSBm/m mice, pointing to a converging mechanism for cochlear defects in CS. Ribbon synapses facilitate rapid and sustained synaptic transmission over long periods of time. Ribeye, a core protein of synaptic ribbons, possesses an NAD(H) binding pocket which regulates its activity. Intriguingly, NAD+ supplementation rescues reduced synaptic ribbon formation in both CSA−/− and CSBm/m mutant cochleae. These findings provide valuable insight into the mechanism of CS- and ARHL-associated hearing loss, and suggest a possible intervention.
Dementia in long-term Parkinson’s disease patients: a multicentre retrospective study
Authors: Szeto Jennifer Y. Y. , Walton Courtney C. , Rizos Alexandra , Martinez-Martin Pablo , Halliday Glenda M. , Naismith Sharon L. , Chaudhuri K. Ray , Lewis Simon J. G. 
Published: January 2020

AbstractWhile several studies have investigated the clinical progression of cognitive decline in Parkinson’s disease (PD) patients, there has been a paucity of data on specifically evaluating PD patients with a disease duration of over 20 years. This study retrospectively investigated the frequency of dementia in PD (PDD) patients with a disease duration of over 20 years assessed in research clinics across the UK and Australia. Data from 2327 PD patients meeting the United Kingdom Parkinson’s Disease Society Brain Bank Criteria was pooled. A diagnosis of probable PDD was made according to the Movement Disorder Society Level 1 criteria. Thirty-six participants had a disease duration of at least 20 years. Of the 36 patients, only 7 (19%) were classified as probable PDD. Compared to PD patients without dementia, those with dementia had lower levels of educational attainment and exhibited more severe motor features. Additionally, 34 out of the 36 patients (94%) exhibited a non-tremor dominant phenotype. No significant differences in age, age onset, disease duration, dopaminergic medication use, and sex distribution were observed between PD patients with and without dementia. Findings from the present study suggest that the prevalence of dementia in long-term PD patients may be lower than anticipated and suggest that the trajectory of cognitive decline in PD patients can be different. These findings highlight the need to investigate factors that might affect the outcome of cognitive decline in long-term PD patients, which may lead to the determination of potential modulating factors in the development of dementia in these patients.
Trust and acceptance of a virtual psychiatric interview between embodied conversational agents and outpatients
Authors: Philip Pierre , Dupuy Lucile , Auriacombe Marc , Serre Fushia , de Sevin Etienne , Sauteraud Alain , Micoulaud-Franchi Jean-Arthur 
Published: January 2020

AbstractVirtual agents have demonstrated their ability to conduct clinical interviews. However, the factors influencing patients’ engagement with these agents have not yet been assessed. The objective of this study is to assess in outpatients the trust and acceptance of virtual agents performing medical interviews and to explore their influence on outpatients’ engagement. In all, 318 outpatients were enroled. The agent was perceived as trustworthy and well accepted by the patients, confirming the good engagement of patients in the interaction. Older and less-educated patients accepted the virtual medical agent (VMA) more than younger and well-educated ones. Credibility of the agent appeared to main dimension, enabling engaged and non-engaged outpatients to be classified. Our results show a high rate of engagement with the virtual agent that was mainly related to high trust and acceptance of the agent. These results open new paths for the future use of VMAs in medicine.
Long-term multi-frequency maser observations of the intermediate-mass young stellar object G107.298+5.639
Authors: Olech M. , Szymczak M. , Wolak P. , Gérard E. , Bartkiewicz A. 
Published: January 2020

Context. Periodic flares of maser emission are thought to be induced either by variations of the seed photon flux in young binary systems or the pump rate regulated by stellar and accretion luminosities.
Aims. We seek to study the variability of four maser transitions of three different species in G107.298+5.639 to constrain the dominant mechanism of periodic flares.
Methods. Light curves of the 6.7 GHz methanol and 22.2 GHz water vapour maser were obtained with the Torun 32 m radio telescope over 39 and 34 cycles, respectively. The target was also monitored at the 1.6 GHz hydroxyl transitions with the Nançay radio telescope over 13 cycles. All these maser lines were imaged using VLBI arrays.
Results. The study confirms alternating flares of the methanol and water masers with a period of 34.4 d and reveals the synchronised behaviour of the methanol and hydroxyl masers in this source. The observed spatial distribution of the methanol maser cloudlets and the measured time delays of the flares of individual features imply a ring-like structure of radius 240 au and thickness 30 au. Internal proper motions indicate that the velocity of methanol cloudlets is dominated by a disc-wind component of about 5 km s−1. The methanol emission detected during only one VLBI observation is located in a region about 550 au from a central star, which also exhibits OH maser flares. The erratic appearance of methanol features can be related to a powering object of relatively low luminosity which, during some variability cycles, can excite molecules only in the nearest part of the disc. A careful analysis of the maser and infrared light curves reveal a strong correlation between the 6.7 GHz line and the infrared flux densities supporting a radiative pumping of the maser.
Conclusions. The synchronised behaviour of the hydroxyl 1665/1667 MHz and 6.7 GHz methanol transitions indicates a common pumping mechanism for the periodic flares of G107.298+5.639.
„CrystalClean“ – Ein deutschsprachiges Manual zur qualifizierten Entgiftungs- und Motivationsbehandlung bei „Crystal Meth“-Abhängigkeit – Durchführbarkeit und Akzeptanz
Authors: Groß Cornelius , Schützwohl Matthias , Mayer-Pelinski René , Hasler Helena , Kirchner Tobias , Scheck Anna , Behrendt Silke , Smolka Michael N. , Zimmermann Ulrich , Lee Nicole K. , Pilhatsch Maximilian 
Published: January 2020

Zusammenfassung
Einleitung Methamphetaminkonsum hat sich im Südosten Deutschlands zu einer flächendeckenden Problematik ausgeweitet. Gleichzeitig fehlen deutschsprachige, standardisierte Therapiemanuale in der Versorgungslandschaft.
Methodik Evaluation von Prozessvariablen eines neuen Manuals für die qualifizierte Entgiftungs- und Motivationsbehandlung der Methamphetaminabhängigkeit. Hierzu wurden 31 Patienten1 (Durchschnittsalter 29 Jahre, 11 weiblich) über 3 Monate regelmäßig untersucht.
Ergebnisse Akzeptanz sowie Durchführbarkeit im stationären Alltag wurden positiv bewertet. Häufung von Abbrüchen bei Übergang in ambulantes Setting.
Schlussfolgerung Das Manual wirkt der Versorgungslücke entgegen. Durchführbarkeit im klinischen Setting ließe sich durch Straffung der Module und höhere Therapiefrequenz verbessern.
Comparison of Lumbar Kinematics with a History of Low Back Pain During Baseball Hitting
Authors: Oshikawa Tomoki , Kaneoka Koji , Morimoto Yasuhiro , Akuzawa Hiroshi 
Published: January 2020

AbstractThe purpose of this study was to examine the influence of a history of low back pain (LBP) on pelvic and lumbar kinematics during baseball hitting. Twenty collegiate male baseball players (age, 21±1 years; height, 172.8±4.7 cm; weight, 72.7±6.2 kg; baseball experience, 13±1 years) performed 5 bat swings. Participants were categorized into the LBP group (n=10) or control group (n=10) based on having experienced lumbar spine pain due to bat swing that lasted more than 24 h within the last 12 months. Three-dimensional kinematic data of the pelvis and lumbar spine during bat swing were measured. Two-way ANOVAs were used to compare pelvic and lumbar kinematics throughout the bat swing between groups, and independent t-tests were used to compare the other outcomes between groups. There was a significant main effect between groups in lumbar flexion angle throughout the bat swing (p=0.047). The mean lumbar flexion angle of the LBP group throughout the bat swing was less than that of the control group. Additionally, the peak angular velocity of lumbar flexion of the LBP group was significantly faster than that of control group (p=0.047). These results can be helpful for longitudinal studies that identify the risk factors of LBP due to bat swing.
Konkretistische Denkstörungen als Indikator der Akuität bei Schizophrenieerkrankungen
Authors: Brackmann Nathalie , Lau Steffen , Habermeyer Elmar , Weiss James 
Published: January 2020

ZusammenfassungFormale Denkstörungen, insbesondere konkretistische, sind ein charakteristisches Merkmal schizophrener Psychosen, welche das Verständnis von idiomatischen Redewendungen, Metaphern und Sprichwörtern im Alltag erschweren oder verunmöglichen. Um die Assoziation zwischen dem Ausmaß des Konkretismusʼ und dem Schweregrad der schizophrenen Erkrankung zu untersuchen, absolvierten 28 Personen mit Schizophrenie nebst der kognitiven Leistungsdiagnostik einen Screening-Sprichwort-Test. Unsere Befunde zeigten einen Zusammenhang zwischen Akuität der schizophrenen Erkrankung und dem Ausmaß des Konkretismusʼ. Der mögliche Mehrgewinn einer Berücksichtigung dieses Befundes bei der Behandlung betroffener Personen wird diskutiert.
Surgical Options and Approaches for Lower Gastrointestinal Bleeding: When do we operate and what do we do?
Authors: Greco Laura , Zhang Jeanette , Ross Howard 
Published: January 2020

AbstractLower gastrointestinal bleeding (LGIB) is a common entity encountered by the surgeon. Though most LGIB stops on its own, familiarity with the diagnoses and their treatments is critical to optimal patient care. Even in 2016, surgery may be required. Advances in imaging have led to an enhanced ability to localize bleeding. Newer anticoagulants have developed which provide ease of use to the patient, but challenges to caregivers when bleeding arises.
Facial Clinimetric Evaluation Scale and Synkinesis Assessment Questionnaire Translation into Brazilian Portuguese: A Validation Study
Authors: Tavares-Brito Joana , Fonseca Anna Carolina de Oliveira , Torres Rodolfo Prado , van Veen Martinus M. , Greene Jacqueline , Salomone Raquel , Bahmad Jr Fayez , Hadlock Tessa , Bento Ricardo Ferreira 
Published: January 2020

Abstract
Introduction Facial nerve palsy results in both functional disability and psychological morbidity. There are several well-established grading scales to quantify the quality of life of these patients.
Objective Translate and validate the Facial Clinimetric Evaluation (FaCE) scale and Synkinesis Assessment Questionnaire (SAQ) to Brazilian Portuguese.
Methods This study adopted a forward-backward translation method and performed cross-cultural adaptation. A pilot study was conducted to correct any confusing language and to evaluate content validity. A validation study was then performed. Internal consistency of the Brazilian Portuguese version of the FaCE and SAQ items was evaluated by Cronbach’s alpha coefficient. Construct validity was assessed by Spearman’s Rank Correlation Coefficient between FaCE and SAQ scores to eFACE, House-Brackmann, Short Form 12 (SF-12) and Facial Disability Index (FDI) (sub)scores.
Results A total of 90 patients were included. Cronbach’s alpha for total domain scored 0.881 for FaCE and 0.809 for SAQ. FaCE total score correlation to eFACE total and House-Brackmann showed Spearman’s r value of 0.537 and −0.538, respectively (p < 0.001). SAQ correlation to eFACE synkinesis subdomain was −0.449 (p < 0.001). No correlation was found between SAQ and HB score. FaCE total score correlations were of 0.301 and 0.547 for SF-12 PCS and MCS, respectively (p < 0.001). Correlation between FaCE total and FDI Physical and Social/well-being functions were 0.498 and 0.567 (p < 0.001).
Conclusion Brazilian Portuguese FaCE scale and SAQ versions achieved high validity and reliability in the present study. These translated instruments demonstrated good psychometric properties, being proper to use in clinical practice in Brazil and with Brazilian Portuguese speakers.
Pseudohypoaldosteronism Type 1 Newborn Patient with a Novel Mutation in SCNN1B
Authors: Seyhanli Muhammed , Ilhan Ozkan , Gumus Evren , Bor Meltem , Karaca Meryem 
Published: January 2020

AbstractPseudohypoaldosteronism is a rare disease characterized by resistance to aldosterone-targeted organs, hyponatremia, hyperkalemia, metabolic acidosis, and severe salt loss in hyperaldosteronism. Homozygous mutations in SCNN1A, SCNN1B, and SCNN1G genes were found to be responsible for the etiology. About 80 cases with molecular basis have been reported to date. In this case, a newborn patient admitted to our neonatal intensive care unit due to feeding problems was examined. The parents of the patient had a consanguineous marriage, and they had lost their three sons due to hyperkalemia. Since she had hyponatremia and hyperkalemia, congenital adrenal hyperplasia was primarily considered. Although the initial evaluation was made in this direction, the patient was diagnosed as pseudohypoaldosteronism type 1 with the findings obtained during the process such as dehydration, cortisol levels, adrenocorticotropic hormone levels, and negative CYP21A2 analysis result. This clinical diagnosis was confirmed by the novel homozygous frame-shift variant c.1245_1246insC (p.N416Qfs*35) in SCNN1B shown by gene analysis. In this report, we seek to emphasize that aldosterone deficiency should be one of the first diagnoses to be considered in neonatal patients with hyponatremia, hyperkalemia, metabolic acidosis, and dehydration.
Dialysis in Pregnancy: Role of the Underlying Cause of Renal Failure on Peripartum Outcomes
Authors: Hoffman Mallory , Sibai Baha 
Published: January 2020

Abstract
Objective Pregnancy on dialysis is rare and few studies in this population exist. Currently, pregnancy outcomes are thought to be related to dialysis intensity. We hypothesize women requiring dialysis due to diabetes or lupus will have worse pregnancy outcomes compared with other indications for dialysis.
Study Design All women receiving dialysis during pregnancy from 2012 to 2016 in a single health system were identified. Differences in perinatal outcomes among those with renal failure caused by diabetes or lupus and with other causes were evaluated.
Results Sixteen women were identified, seven with diabetes or lupus causing renal failure; the remaining nine women had hypertension, focal segmental glomerular sclerosis, polycystic kidney disease, congenital hypoplastic kidneys, or neurogenic bladder. The rates of composite maternal morbidity were similar among the two groups. Composite neonatal morbidity was higher in those with renal failure caused by diabetes or lupus compared with other causes (100% vs. 29%, p = 0.028).
Conclusion Despite similar dialysis intensity, the composite neonatal morbidity was higher in women with renal failure caused by diabetes or lupus compared with other etiologies. Our findings suggest that pregnancy outcome in women receiving dialysis is dependent on both the intensity of dialysis as well as the etiology of renal failure.
A Novel Endoscopic Forehead Lift Technique for Patients with Upper Facial Wrinkles: Morphometric Evaluation and Patient-Reported Outcome using FACE-Q Scales
Authors: Wang Guanhuier , Tao Liyuan , Xie Hongbin 
Published: January 2020

AbstractChinese patients more frequently complain of forehead wrinkles than eyebrow and upper eyelid ptosis. Besides the commonly used brow-lifting technique, a novel technique to satisfy the demands of Chinese patients is needed. In this article, we introduce our novel endoscopic forehead lift procedure and analyze the morphometric evaluation and patient-reported outcomes. From January 2010 to January 2017, 171 Chinese patients underwent endoscopic forehead lift in which two parallel incisions were made on the frontalis muscle to relieve forehead wrinkles. Biopsy forceps were used to bite off the glabella muscles to relieve wrinkles between the eyebrows. Lifting devices were not used. Morphometric evaluations of eyebrow locations were performed, and the vertical distance of the upper eyebrows was measured post- and preoperatively to evaluate the elevation range. FACE-Q scales were sent to patients who were still being followed-up. A total of 46 patients underwent the morphometric evaluation, which suggested that the eyebrows were elevated effectively. At 12 to 36 months postoperatively, the median post-/preoperative ratio was 118.4, 112.5, and 111.8% in the medial, middle, and lateral eyebrows, respectively. In the same patients, at 37 to 84 months postoperatively, the median post-/preoperative ratio was 116.6, 112.2, and 108.9% in the medial, middle, and lateral eyebrows, respectively. Sixty-five patients completed the FACE-Q scales, demonstrating high satisfaction levels with the forehead and eyebrow, outcome, and decisions, with a median score of 100 for each. Postoperative appraisal revealed that the lines in the forehead and between the eyebrows had a good outcome with scores of 86 and 93, respectively. The median number of years younger that patients thought they appeared was 7. The most frequent self-claimed recovery symptom was temporary forehead skin numbness (83.1%) followed by a receding hairline (46.2%). Our endoscopic forehead lift procedure was effective in relieving forehead and glabella wrinkles and lifting the eyebrows. This was a level of evidence III study.
Adolescents’ perceptions of family social status correlate with health and life chances: A twin difference longitudinal cohort study
Authors: Rivenbark Joshua , Arseneault Louise , Caspi Avshalom , Danese Andrea , Fisher Helen L. , Moffitt Terrie E. , Rasmussen Line J. H. , Russell Michael A. , Odgers Candice L. 
Published: January 2020

Significance
Despite growing up in the same family, siblings do not always see their family’s social standing identically. Eighteen-year-old twins who rated their family as having higher social standing, compared with their cotwin’s rating, had fewer difficulties negotiating the transition to adulthood: they were less likely to be convicted of a crime, not in education, employment, or training, and had fewer mental health problems. The same pattern of findings was not seen earlier in adolescence when the twins were aged 12 y. By late adolescence, young people’s beliefs about where their family was located in a hierarchical social system signaled how well they were doing, irrespective of their families’ access to objective financial resources and their earlier psychological vulnerabilities.
Specialized stellate cells offer a privileged route for rapid water flux in
Drosophila
renal tubule
Authors: Cabrero Pablo , Terhzaz Selim , Dornan Anthony J. , Ghimire Saurav , Holmes Heather L. , Turin Daniel R. , Romero Michael F. , Davies Shireen A. , Dow Julian A. T. 
Published: January 2020

Significance
The tiny insect renal (Malpighian) tubule can transport fluid at unparalleled speed, suggesting unique specializations. Here we show that strategic allocation of major intrinsic proteins (MIPs) to specific cells within the tubule allows the separation of metabolically intense active cation transport from passive chloride and water conductance. This specialized renal architecture is general to at least many higher insects, providing a clue to the unique success of the class Insecta in colonizing an extraordinary range of ecological niches.
De l’histoire de la traduction en Serbie : la science médiévale et la création des terminologies
Authors: Vinaver Nadežda 
Published: January 2020

Abstrait
Dans la communication sur les terminologies médiévales et les sciences respectives est examiné un recueil de
textes médicaux serbes du Moyen âge (XIIe–XVe siècles), intitulé le Code médical du Chilandar, retrouvé en 1952
dans la bibliothèque du monastère serbe Chilandar au mont Athos (en Grèce), et il est comparé à la tradition médicale et
pharmacologique en latin des grandes écoles médiévales occidentales. Dans le cadre des oppositions entre les langues et cultures,
on verra qu’on ne peut indiquer les référents des expressions sans connaître le monde duquel ces référents sont prélevés.
Exploring the emotional problems and mental health needs of elementary school children using cochlear implants or hearing aids in the Islas Canarias
Authors: Alegre de la Rosa Olga María , Villar Angulo Luis Miguel 
Published: January 2020

Purpose:
The study aimed to investigate whether emotional and behavioral strengths and difficulties differ between children with cochlear implants (CIs) or hearing aids (HAs), to correlate the outcomes of children on four psychological instruments, and to identify new socio-demographic and linguistic predictors of emotional and behavioral strengths and difficulties in children. A battery of psychological instruments (SDQ, ITPA, Peabody, and Raven’s) was administered to children in two provinces of the Canary Islands, Spain.

Method:
The study involved 187 children with CIs, 113 children with HAs, 176 parents, and 300 schoolteachers.

Results:
Rating disagreements were found between children, parents, and schoolteachers in terms of their SDQ ratings. Total SDQ score correlated weakly with other total ITPA subtests, and the final Peabody and Raven’s outcomes. Six socio-demographic and linguistic factors significantly predicted children’s overall strengths and difficulties.

Conclusion:
Findings have consequences for implementing instructional systems for children who are in need of personal and educational support.