bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fuentes judiciales para la historia de la Provincia del Paraguay, siglos XVII y XVIII.
Authors: Caballero Campos Herib 
Published: October 2020

Este artículo realiza un análisis heurístico de la Sección Civil y Judicial del Archivo Nacional de Asunción y como la documentación puede ser útil para comprender las dinámicas familiares, sociales, económicas y religiosas en una provincia situada en los confines de los dominios hispanos. El Archivo Nacional de Asunción remonta su origen a fines del siglo XVI por disposición del gobernador Hernando Arias de Saavedra. Originalmente los documentos que conforman la sección provienen de los juzgados de 1er y 2do voto del Cabildo de Asunción. Se procederá a analizar la documentación en los dos siglos más completos de la misma que son los siglos XVII y XVIII. Se determinará la tipología documental, el objeto entre otros aspectos que ayuden a caracterizar los expedientes que integran dicha colección.
This article makes an heuristic analysis of the Civil and Judiciary Section of the National Archive of Asunción and how the documentation can be useful for the comprehension of the dynamics in the families, society, economics and religious aspects in the province located in the bounds of the Hispanic possessions. The National Archive of Asunción was originated in the late 16th century after a provision of the governor Hernando Arias de Saavedra. Originally the files that made up the section come from the 1st and 2nd courts of the Asunción City Council. The text will proceed to an analysis in the two more complete centuries of the same of the documentation, which were the 17th and 18th centuries. It will be to determine a documentary typology, as well as the object between other aspects that could help characterize the files that are part of this collection.
El estudio de la minería colonial Altoandina desde las fuentes fiscales, siglos XVII y XVIII.
Authors: Gavira Márquez María Concepción 
Published: October 2020

Este trabajo pretende reflexionar sobre las fuentes que abordamos los investigadores para el estudio de la historia de la minería colonial, analizando los aportes y las limitaciones de las distintas fuentes, así como la incorporación de nuevas preguntas que han permitido ampliar el conocimiento de esta importante actividad en la América colonial. Nos vamos a centrar en las fuentes fiscales, especialmente en los libros contables de las Cajas Reales, los cuales nos ofrecen muchas posibilidades, aunque también hablaremos de las limitaciones a la hora de tomar esta información como concluyente sin someterla a un riguroso análisis y sin completar el estudio con otro tipo de documentación.
This work aims to ponder the sources used by researchers to study colonial mining. Analyzing its contributions and limits, and also, the appearance of new questions which have enabled the increasing of knowledge about this important activity in colonial America. We will focus on fiscal sources, especially on accounting books of the Cajas Reales, which offer us many possibilities, although we will also talk about the limitations when thinking of this information as conclusive, without subjecting it to a stringent analysis, and without completing the study with other source of documentation.
Conflicting phylogenetic signals in plastomes of the tribe Laureae (Lauraceae)
Authors: Xiao Tian-Wen , Xu Yong , Jin Lu , Liu Tong-Jian , Yan Hai-Fei , Ge Xue-Jun 
Published: October 2020

Background
Gene tree discordance is common in phylogenetic analyses. Many phylogenetic studies have excluded non-coding regions of the plastome without evaluating their impact on tree topology. In general, plastid loci have often been treated as a single unit, and tree discordance among these loci has seldom been examined. Using samples of Laureae (Lauraceae) plastomes, we explored plastome variation among the tribe, examined the influence of non-coding regions on tree topology, and quantified intra-plastome conflict.

Results
We found that the plastomes of Laureae have low inter-specific variation and are highly similar in structure, size, and gene content. Laureae was divided into three groups, subclades I, II and III. The inclusion of non-coding regions changed the phylogenetic relationship among the three subclades. Topologies based on coding and non-coding regions were largely congruent except for the relationship among subclades I, II and III. By measuring the distribution of phylogenetic signal across loci that supported different topologies, we found that nine loci (two coding regions, two introns and five intergenic spacers) played a critical role at the contentious node.

Conclusions
Our results suggest that subclade III and subclade II are successively sister to subclade I. Conflicting phylogenetic signals exist between coding and non-coding regions of Laureae plastomes. Our study highlights the importance of evaluating the influence of non-coding regions on tree topology and emphasizes the necessity of examining discordance among different plastid loci in phylogenetic studies.
Colonization of novel algal habitats by juveniles of a marine tube-dwelling amphipod
Authors: Bueno Marilia , Machado Glauco B.O. , Leite Fosca P.P. 
Published: October 2020

Background
Dispersal is an important process affecting population dynamics and connectivity. For marine direct developers, both adults and juveniles may disperse. Although the distribution of juveniles can be initially constrained by their mothers’ choice, they may be able to leave the parental habitat and colonize other habitats. We investigated the effect of habitat quality, patch size and presence of conspecific adults on the colonization of novel habitats by juveniles of the tube-dwelling amphipod Cymadusa filosa associated with the macroalgal host Sargassum filipendula.

Methods
We tested the factors listed above on the colonization of juveniles by manipulating natural and artificial plants in both the field and laboratory.

Results
In the laboratory, juveniles selected high-quality habitats (i.e., natural alga), where both food and shelter are provided, when low-quality resources (i.e., artificial alga) were also available. In contrast, habitat quality and algal patch size did not affect the colonization by juveniles in the field. Finally, the presence of conspecific adults did not affect the colonization of juveniles under laboratory condition but had a weak effect in the field experiment. Our results suggest that C. filosa juveniles can select and colonize novel habitats, and that such process can be partially affected by habitat quality, but not by patch size. Also, the presence of conspecifics may affect the colonization by juveniles. Successful colonization by this specific developmental stage under different scenarios indicates that juveniles may act as a dispersal agent in this species.
IL35 predicts prognosis in gastric cancer and is associated with angiogenesis by altering TIMP1, PAI1 and IGFBP1
Authors: Li Xiao , Niu Nan , Sun Jing , Mou Yiping , He Xujun , Mei Linhang 
Published: October 2020

Tumor angiogenesis is required for tumor growth and metastasis. Interleukin‐35 (IL35), a member of the IL12 family, is a dimer composed of IL12A and EBV‐induced gene 3（EBI3）. Elevated plasma IL35 levels have been reported to be associated with the occurrence and development of tumors. However, the role of IL35 in the angiogenesis of gastric cancer (GC) is still unclear. Here, we report that expression of IL35 is correlated with higher microvessel density, distant metastasis and poor prognosis in GC. Moreover, in vitro tube formation assays were performed to show that IL35 may contribute to the tube formation abilities of human umbilical vein endothelial cells. IL12A was observed to be the dominant subunit in promotion of tube formation. IL12A also inhibited expression of tissue inhibitor of metalloproteinase 1 and enhanced expression of plasminogen activator inhibitor 1 and insulin‐like growth factor‐binding protein 1 in a GC cell line. In conclusion, our data suggest that IL35 is involved in angiogenesis and is associated with poor prognosis for GC.
High‐Performance Near‐Infrared Photodetectors Based on Surface‐Doped InSe
Authors: Jang Hanbyeol , Seok Yongwook , Choi YiTaek , Cho Sang‐Hoo , Watanabe Kenji , Taniguchi Takashi , Lee Kayoung 
Published: October 2020

Abstract2D InSe is one of the semimetal chalcogenides that has been recently given attention thanks to its excellent electrical properties, such as high mobility near 1000 cm2 V−1 s−1 and moderate band gap of ≈1.26 eV suitable for IR detection. Here, high‐performance visible to near‐infrared (470–980 nm wavelength (λ)) photodetectors using surface‐doped InSe as a channel and few‐layer graphenes (FLG) as electrodes are reported, where the InSe top region is relatively p‐doped using AuCl3. The surface‐doped InSe photodetectors show outstanding performance, achieving a photoresponsivity (R) of ≈19 300 A W−1 and a detectivity (D*) of ≈3 × 1013 Jones at λ = 470 nm, and R of ≈7870 A W−1 and D* of ≈1.5 × 1013 Jones at λ = 980 nm, superior to previously reported 2D material‐based IR photodetectors operating without an applied gate bias. Surface doping using AuCl3 renders a band bending at the junction between the InSe surface and the top FLG contact, which facilitates electron‐hole pair separation and immediate photodetection. Multiple doped or undoped InSe photodetectors with different device structures are investigated, providing insight into the photodetection mechanism and optimizing performance. Encapsulation with hexagonal boron nitride dielectric also allows for 3‐month stability.
Single‐Material OECT‐Based Flexible Complementary Circuits Featuring Polyaniline in Both Conducting Channels
Authors: Travaglini Lorenzo , Micolich Adam P. , Cazorla Claudio , Zeglio Erica , Lauto Antonio , Mawad Damia 
Published: October 2020

AbstractThe organic electrochemical transistor (OECT) with a conjugated polymer as the active material is the elementary unit of organic bioelectronic devices. Improved functionalities, such as low power consumption, can be achieved by building complementary circuits featuring two or more OECTs. Complementary circuits commonly combine both p‐ and n‐type transistors to reduce power draw. While p‐type OECTs are readily available, n‐type OECTs are less common mainly due to poor stability of the n‐type active channel material in aqueous electrolyte. Here, a complementary circuit is made using a pair of OECTs having polyaniline (PANI) as the channel material in both transistors. PANI, with a finite electrochemical window accessible at voltages lower than 1 V, exhibits a peak in current versus gate voltage when used as an active channel in an OECT. The current peak has two slopes, one n‐like and one p‐like, which correspond to different electrochemical regimes of the same underlying conjugated polymer. The electrochemistry enables the design of a complementary circuit using only PANI as the channel material. The PANI‐based circuit is shown to have excellent performance with gain of ≈7 and is transferred on a flexible biocompatible chitosan substrate with demonstrated operation in aqueous electrolyte.
Protein Arginine Methyltransferase PRMT5 Regulates Fatty Acid Metabolism and Lipid Droplet Biogenesis in White Adipose Tissues
Authors: Jia Zhihao , Yue Feng , Chen Xiyue , Narayanan Naagarajan , Qiu Jiamin , Syed Sabriya A. , Imbalzano Anthony N. , Deng Meng , Yu Peng , Hu Changdeng , Kuang Shihuan 
Published: October 2020

AbstractThe protein arginine methyltransferase 5 (PRMT5) is an emerging regulator of cancer and stem cells including adipogenic progenitors. Here, a new physiological role of PRMT5 in adipocytes and systemic metabolism is reported. Conditional knockout mice were generated to ablate the Prmt5 gene specifically in adipocytes (Prmt5AKO). The Prmt5AKO mice exhibit sex‐ and depot‐dependent progressive lipodystrophy that is more pronounced in females and in visceral (than subcutaneous) white fat. The lipodystrophy and associated energy imbalance, hyperlipidemia, hepatic steatosis, glucose intolerance, and insulin resistance are exacerbated by high‐fat‐diet. Mechanistically, Prmt5 methylates and releases the transcription elongation factor SPT5 from Berardinelli‐Seip congenital lipodystrophy 2 (Bscl2, encoding Seipin) promoter, and Prmt5AKO disrupts Seipin‐mediated lipid droplet biogenesis. Prmt5 also methylates Sterol Regulatory Element‐Binding Transcription Factor 1a (SREBP1a) and promotes lipogenic gene expression, and Prmt5AKO suppresses SREBP1a‐dependent fatty acid metabolic pathways in adipocytes. Thus, PRMT5 plays a critical role in regulating lipid metabolism and lipid droplet biogenesis in adipocytes.
Impact of spleen size and splenectomy on outcomes of allogeneic hematopoietic cell transplantation for myelofibrosis: A retrospective analysis by the chronic malignancies working party on behalf of European society for blood and marrow transplantation (EBMT)
Authors: Polverelli Nicola , Mauff Katya , Kröger Nicolaus , Robin Marie , Beelen Dietrich , Beauvais David , Chevallier Patrice , Mohty Mohamad , Passweg Jakob , Rubio Marie Thérèse , Maertens Johan , Finke Jürgen , Bornhäuser Martin , Vrhovac Radovan , Helbig Grzegorz , Mear Jean‐Baptiste , Castagna Luca , Reményi Péter , Angelucci Emanuele , Karakasis Dimitrios , Rifòn Jose , Sirait Tiarlan , Russo Domenico , de Wreede Liesbeth , Czerw Tomasz , Hernández‐Boluda Juan Carlos , Hayden Patrick , McLornan Donal , Yakoub‐Agha Ibrahim 
Published: October 2020

AbstractThe role of spleen size and splenectomy for the prediction of post‐allogeneic hematopoietic stem cell transplant (allo‐HCT) outcome in myelofibrosis remains under debate. In EBMT registry, we identified a cohort of 1195 myelofibrosis patients transplanted between 2000‐2017 after either fludarabine‐busulfan or fludarabine‐melphalan regimens. Overall, splenectomy was performed in 202 (16.9%) patients and its use decreased over time (28.3% in 2000‐2009 vs 14.1% in 2010‐2017 period). By multivariate analysis, splenectomy was associated with less NRM (HR 0.64, 95% CI 0.44‐0.93, P = .018) but increased risk of relapse (HR 1.43, 95% CI 1.01‐2.02, P = .042), with no significant impact on OS (HR 0.86, 95% CI 0.67‐1.12, P = .274). However, in subset analysis comparing the impact of splenectomy vs specific spleen sizes, for patients with progressive disease, an improved survival was seen in splenectomised subjects compared to those patients with a palpable spleen length ≥ 15 cm (HR 0.44, 95% CI 0.28‐0.69, P < .001), caused by a significant reduction in NRM (HR 0.26, 95% CI 0.14‐0.49, P < .001), without significantly increased relapse risk (HR 1.47, 95% CI 0.87‐2.49, P = .147). Overall, despite the possible biases typical of retrospective cohorts, this study highlights the potential detrimental effect of massive splenomegaly in transplant outcome and supports the role of splenectomy for myelofibrosis patients with progressive disease and large splenomegaly.
Elucidation of the Chemical Role of the Pyroclastic Materials on the State of Conservation of Mural Paintings from Pompeii
Authors: Pérez‐Diez Silvia , Fernández‐Menéndez Luis Javier , Morillas Héctor , Martellone Alberta , De Nigris Bruno , Osanna Massimo , Bordel Nerea , Caruso Francesco , Madariaga Juan Manuel , Maguregui Maite 
Published: October 2020

AbstractPyroclastic strata have always been thought to protect the archaeological remains of the Vesuvian area (Italy), hence allowing their conservation throughout the centuries. In this work, we demonstrate that they constitute a potential threat for the conservation state of the mural paintings of Pompeii. The ions that could be leached from them and the ion‐rich groundwater coming from the volcanic soil/rocks may contribute to salt crystallisation. Thermodynamic modelling not only allowed to predict which salts can precipitate from such leaching events but also assisted the identification of additional sources of sulfates and alkali metals to explain the formation of the sulfates identified in efflorescences from the mural paintings of Pompeii. For the future, fluorine, mainly related to a volcanic origin, can be proposed as a marker to monitor the extent of the impact in the mural paintings of Pompeii in situ.
15N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields
Authors: Salnikov Oleg G. , Chukanov Nikita V. , Svyatova Alexandra , Trofimov Ivan A. , Kabir Mohammad S. H. , Gelovani Juri G. , Kovtunov Kirill V. , Koptyug Igor V. , Chekmenev Eduard Y. 
Published: October 2020

AbstractNimorazole belongs to the imidazole‐based family of antibiotics to fight against anaerobic bacteria. Moreover, nimorazole is now in Phase 3 clinical trial in Europe for potential use as a hypoxia radiosensitizer for treatment of head and neck cancers. We envision the use of [15N3]nimorazole as a theragnostic hypoxia contrast agent that can be potentially deployed in the next‐generation MRI‐LINAC systems. Herein, we report the first steps to create long‐lasting (for tens of minutes) hyperpolarized state on three 15N sites of [15N3]nimorazole with T1 of up to ca. 6 minutes. The nuclear spin polarization was boosted by ca. 67000‐fold at 1.4 T (corresponding to P15N of 3.2 %) by 15N−15N spin‐relayed SABRE‐SHEATH hyperpolarization technique, relying on simultaneous exchange of [15N3]nimorazole and parahydrogen on polarization transfer Ir‐IMes catalyst. The presented results pave the way to efficient spin‐relayed SABRE‐SHEATH hyperpolarization of a wide range of imidazole‐based antibiotics and chemotherapeutics.
A Genetic Code Expansion‐Derived Molecular Beacon for the Detection of Intracellular Amyloid‐β Peptide Generation
Authors: Sappakhaw Khomkrit , Jantarug Krittapas , Slavoff Sarah A. , Israsena Nipan , Uttamapinant Chayasith 
Published: October 2020

AbstractPolypeptides generated from proteolytic processing of protein precursors, or proteolytic proteoforms, play an important role in diverse biological functions and diseases. However, their often‐small size and intricate post‐translational biogenesis preclude the use of simple genetic tagging in their cellular studies. Herein, we develop a labeling strategy for this class of proteoforms, based on residue‐specific genetic code expansion labeling with a molecular beacon design. We demonstrate the utility of such a design by creating a molecular beacon reporter to detect amyloid‐β peptides, known to be involved in the pathogenesis of Alzheimer's disease, as they are produced from amyloid precursor protein (APP) along the endocytic pathway of living cells.
Dinuclear Triple‐Stranded Helicates Composed of Tetradentate Ligands with Aluminum(III) Chromophores: Optical Resolution and Multi‐color Circularly Polarized Luminescence Properties
Authors: Ono Toshikazu , Ishihama Kohei , Taema Ai , Harada Takunori , Furusho Kiyonao , Hasegawa Masashi , Nojima Yuki , Abe Masaaki , Hisaeda Yoshio 
Published: October 2020

AbstractNew chiroptical chromophores, dinuclear triple‐stranded helicates, composed of tetradentate ligands with aluminum(III) ions, are described. These are synthesized in two steps using inexpensive pyrrole derivatives, hydrazine, and aluminum chloride. These molecular architectures (ALPHY) show multi‐color (cyan, yellow, and orange) photoluminescence in solution and in the solid‐state, which depends on the substituents of the ligands. The photoluminescence quantum yields of helicates were up to 54 %. The right‐handed (P) and left‐handed (M) helicates are so stable that they do not undergo racemization in some solvents and are mirror images according to circular dichroism and circularly polarized luminescence (CPL) with an absolute luminescence dissymmetry factor (glum) of up to the 10−3 order. Mixing the different helicates produces white‐light emission with CPL characters. This study offers a glimpse into the potential applications of chromophores with diverse photophysical properties.
Discovery of Key TIPS‐Naphthalene for Efficient Visible‐to‐UV Photon Upconversion under Sunlight and Room Light**
Authors: Harada Naoyuki , Sasaki Yoichi , Hosoyamada Masanori , Kimizuka Nobuo , Yanai Nobuhiro 
Published: October 2020

AbstractWhile many studies have been done on triplet–triplet annihilation‐based photon upconversion (TTA‐UC) to produce visible light with high efficiency, the efficient TTA‐UC from visible to UV light, despite its importance for a variety of solar and indoor applications, remains a challenging task. Here, we report the highest visible‐to‐UV TTA‐UC efficiency of 20.5 % based on the discovery of an excellent UV emitter, 1,4‐bis((triisopropylsilyl)ethynyl)naphthalene (TIPS‐Nph). TIPS‐Nph is an acceptor with desirable features of high fluorescence quantum yield and high singlet generation efficiency by TTA. TIPS‐Nph has a low enough triplet energy level to be sensitized by Ir(C6)2(acac), a superior donor that does not quench UV emission. The combination of TIPS‐Nph and Ir(C6)2(acac) realizes the efficient UV light production even with weak light sources such as an AM 1.5 solar simulator and room LEDs.
A novel approach to spinal anaesthesia to avoid aerosol‐generating procedures in a patient with COVID‐19 presenting for laser prostate surgery
Authors: Oon Z. , Ha C. 
Published: October 2020

SummaryGeneral anaesthesia involves aerosol‐generating procedures which, in the context of the coronavirus 2019 (COVID‐19) pandemic, increases the risk of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) transmission from patients to staff. This risk can be minimised by performing spinal or regional anaesthesia instead of general anaesthesia where possible. We report the successful management of a patient utilising spinal anaesthesia in a patient with COVID‐19 undergoing urgent holmium laser enucleation of prostate for symptomatic benign prostatic hyperplasia. A combination of bupivacaine, diamorphine and midazolam was administered intrathecally which provided adequate anaesthesia despite the prolonged surgical duration. Nebulised lidocaine was also given to prevent coughing during the procedure. This report demonstrates that it is possible and safe to use spinal anaesthesia to perform prolonged surgical procedures that are normally conducted under general anaesthesia using a combination of intrathecal adjuncts to facilitate effective block duration. In addition, the novel use of nebulised lidocaine for its antitussive effects in a patient with COVID‐19 is highlighted.
Glass bubble reinforced polyurethane foams with high mechanical strength for cryogenic temperature insulation
Authors: Kim Jeong‐Dae , Kim Jeong‐Hyeon , Ahn Jae‐Hyeok , Lee Jae‐Myung 
Published: October 2020

AbstractIn this study, glass bubble (GB) is added to polyurethane (PU) foams at different weight ratios—0, 0.25, 0.5, 0.75, and 1 wt% —to investigate the changes in the mechanical and thermal properties of the foam. By conducting several tests and measurements, the density, cell morphology, compressive strength, and thermal conductivity of the foam are studied. In particular, the effect of GB additives is examined by conducting compression tests at various temperatures (−163, −100, −40, and 20°C). Scanning electron microscopy and X‐ray microscope reveal that the foams exhibit higher stability below 0.5 wt%, which improves the thermal performance. On the other hand, the compressive strength of the foams increases for all weight ratios of GB, and it increases sharply at 0.75 wt%. In addition, the chemical interactions and the dispersion of additives in the PU matrix are investigated through Fourier transform infrared and X‐ray diffractions analysis. It is found that the synthesis of PU foams with GB nanoparticles is an efficient method for improving the mechanical properties and insulation performance of the foam for LNG insulation technology.