bluuebunny/crossref_metadata_2025_split huggingface dataset:
Naturalistic outcomes for a day‐hospital programme in a mixed diagnostic sample of adolescents with eating disorders
Authors: Reilly Erin E. , Rockwell Roxanne E. , Ramirez Ana L. , Anderson Leslie K. , Brown Tiffany A. , Wierenga Christina E. , Kaye Walter H. 
Published: January 2020

AbstractDespite initial data suggesting positive treatment outcomes for adolescent eating disorder day‐hospital programmes (DHPs), existing studies have included limited follow‐up, small samples, and a focus on restricting‐type eating disorders. To address these gaps, we explored naturalistic outcomes for an adolescent eating disorders DHP. Adolescent participants (N = 265) completed measurements at treatment admission, discharge (n = 170), and various lengths of follow‐up (n = 126; Mfollow up = 278.87 days). Results from multilevel models indicated significant increases in body weight for the anorexia nervosa group throughout treatment and maintenance of increased body weight from discharge to follow‐up. In bulimic spectrum disorders, binge eating and purging significantly decreased from intake to discharge and did not change from discharge to follow‐up. Across the entire sample, eating disorder symptoms decreased from intake to discharge and did not change from discharge to follow‐up. Further, anxiety and depression decreased over the course of treatment and continued to decrease over the follow‐up period. The current investigation represents the first study to explore longitudinal DHP outcomes within adolescent bulimic spectrum eating disorders. Our findings also highlight many challenges inherent in conducting naturalistic research; it is critical that the field continue to develop solutions to the barriers inherent in conducting longitudinal research on eating disorder treatment.
Computation of storage power and energy to stabilize a wind‐and‐solar‐only Australian National Electricity Market grid
Authors: Boretti Alberto , Nayfeh Jamal , Al‐Kouz Wael 
Published: January 2020

AbstractThe Australian NEM grid data is a unique example worldwide. No other country supplies high frequency (5‐minutes‐sampling‐interval) data of power generation by all the facilities connected to a grid. The NEM grid has power demands between 18 and 36 GW, on average 27 GW. Presently, wind energy nominal capacity is 6.7 GW, solar energy nominal capacity is 11.4 GW storage power and energy is negligible. Capacity factors are about 0.33 for wind, and about 0.125 for solar (0.27 facilities, 0.10 rooftop). Wind and solar capacities must be increased to 53.2 and 90.5 GW (growth factor 7.94) to cover the NEM grid demand. Minimum storage power needed is more than 45 GW net, while the net storable energy is computed as 3500 GW h. The nominal power and energy are much more than that, depending on the specific technology adopted, as storage only works at a fraction of the nominal power during charge and discharge, and only a fraction of the nominal capacity, with round‐trip efficiencies everything but unity. While the trend is to move towards more solar rooftop, this not the case, as it further increases variability and needs larger storage.
Impact of Hydroponic Oxygen Control in Sulfide Toxicity to Early Life Stages of Wild Rice (Zizania palustris)
Authors: Fort Douglas J. , Mathis Michael B. , Anderson Kurt , Beranek Rob 
Published: January 2020

Abstract
Low-headspace oxygen was used in the hydroponic design to evaluate the toxicity of sulfide to wild rice (Zizania palustris). Oxygen levels in the headspace gas phase were maintained at &lt;0.005 atm. The results indicated that mesocotyl emergence was the most sensitive endpoint (≥3.1 mg/L sulfide and 0.8 mg/L iron [Fe]). At 2.8 mg Fe/L, ≥7.8 mg/L sulfide was required to reduce emergence, shoot weight, and shoot length. Overall, the results were similar to those of previous studies in which atmospheric oxygen was maintained in the headspace gas phase, demonstrating that the oxygen level in the headspace gas phase during mesocotyl emergence and early growth was not a significant factor in sulfide tolerance. Environ Toxicol Chem 2020;39:659–666. © 2020 SETAC
Measurement of ultra‐fast signal progression related to face processing by 7T fMRI
Authors: Choi Uk‐Su , Sung Yul‐Wan , Ogawa Seiji 
Published: January 2020

AbstractGiven that the brain is a dynamic system, the temporal characteristics of brain function are important. Previous functional magnetic resonance imaging (fMRI) studies have attempted to overcome the limitations of temporal resolution to investigate dynamic states of brain activity. However, finding an fMRI method with sufficient temporal resolution to keep up with the progress of neuronal signals in the brain is challenging. This study aimed to detect between‐hemisphere signal progression, occurring on a timescale of tens of milliseconds, in the ventral brain regions involved in face processing. To this end, we devised an inter‐stimulus interval (ISI) stimulation scheme and used a 7T MRI system to obtain fMRI signals with a high signal‐to‐noise ratio. We conducted two experiments: one to measure signal suppression depending on the ISI and another to measure the relationship between the amount of suppression and the ISI. These two experiments enabled us to measure the signal transfer time from a brain region in the ventral visual stream to its counterpart in the opposite hemisphere through the corpus callosum. These findings demonstrate the feasibility of using fMRI to measure ultra‐fast signals (tens of milliseconds) and could facilitate the elucidation of further aspects of dynamic brain function.
Tractostorm: The what, why, and how of tractography dissection reproducibility
Authors: Rheault Francois , De Benedictis Alessandro , Daducci Alessandro , Maffei Chiara , Tax Chantal M. W. , Romascano David , Caverzasi Eduardo , Morency Felix C. , Corrivetti Francesco , Pestilli Franco , Girard Gabriel , Theaud Guillaume , Zemmoura Ilyess , Hau Janice , Glavin Kelly , Jordan Kesshi M. , Pomiecko Kristofer , Chamberland Maxime , Barakovic Muhamed , Goyette Nil , Poulin Philippe , Chenot Quentin , Panesar Sandip S. , Sarubbo Silvio , Petit Laurent , Descoteaux Maxime 
Published: January 2020

AbstractInvestigative studies of white matter (WM) brain structures using diffusion MRI (dMRI) tractography frequently require manual WM bundle segmentation, often called “virtual dissection.” Human errors and personal decisions make these manual segmentations hard to reproduce, which have not yet been quantified by the dMRI community. It is our opinion that if the field of dMRI tractography wants to be taken seriously as a widespread clinical tool, it is imperative to harmonize WM bundle segmentations and develop protocols aimed to be used in clinical settings. The EADC‐ADNI Harmonized Hippocampal Protocol achieved such standardization through a series of steps that must be reproduced for every WM bundle. This article is an observation of the problematic. A specific bundle segmentation protocol was used in order to provide a real‐life example, but the contribution of this article is to discuss the need for reproducibility and standardized protocol, as for any measurement tool. This study required the participation of 11 experts and 13 nonexperts in neuroanatomy and “virtual dissection” across various laboratories and hospitals. Intra‐rater agreement (Dice score) was approximately 0.77, while inter‐rater was approximately 0.65. The protocol provided to participants was not necessarily optimal, but its design mimics, in essence, what will be required in future protocols. Reporting tractometry results such as average fractional anisotropy, volume or streamline count of a particular bundle without a sufficient reproducibility score could make the analysis and interpretations more difficult. Coordinated efforts by the diffusion MRI tractography community are needed to quantify and account for reproducibility of WM bundle extraction protocols in this era of open and collaborative science.
Liver Diseases in the Perinatal Period: Interactions Between Mother and Infant
Authors: Ibrahim Samar H. , Jonas Maureen M. , Taylor Sarah A. , Gutierrez Sanchez Luz Helena , Wolf Jaqueline L. , Sundaram Shikha S. 
Published: January 2020

Liver diseases affecting the mother and infant dyad may present in the perinatal period from 20 weeks of gestation to 28 days of life. This review will focus on the current approach to neonatal acute liver failure and the progress made in the diagnosis and management of gestational alloimmune liver disease. It will highlight mother‐to‐child transmission of viral hepatitis, both management and public health implications. Emerging concepts implicating maternal obesity and nutrition in the development of a rapidly progressive nonalcoholic steatohepatitis phenotype in the offspring will be discussed. Finally, the presentation and management of acute fatty liver of pregnancy and intrahepatic cholestasis of pregnancy, and their impact on the fetus, will be reviewed.
Genomic Characterization of Cholangiocarcinoma in Primary Sclerosing Cholangitis Reveals Therapeutic Opportunities
Authors: Goeppert Benjamin , Folseraas Trine , Roessler Stephanie , Kloor Matthias , Volckmar Anna‐Lena , Endris Volker , Buchhalter Ivo , Stenzinger Albrecht , Grzyb Krzysztof , Grimsrud Marit M. , Gornicka Barbara , von Seth Erik , Reynolds Gary M. , Franke Andre , Gotthardt Daniel N. , Mehrabi Arianeb , Cheung Angela , Verheij Joanne , Arola Johanna , Mäkisalo Heikki , Eide Tor J. , Weidemann Sören , Cheville John C. , Mazza Giuseppe , Hirschfield Gideon M. , Ponsioen Cyriel Y. , Bergquist Annika , Milkiewicz Piotr , Lazaridis Konstantinos N. , Schramm Christoph , Manns Michael P. , Färkkilä Martti , Vogel Arndt ,   International PSC Study Group, Boberg Kirsten M. , Schirmacher Peter , Karlsen Tom H. 
Published: January 2020

Background and Aims
Lifetime risk of biliary tract cancer (BTC) in primary sclerosing cholangitis (PSC) may exceed 20%, and BTC is currently the leading cause of death in patients with PSC. To open new avenues for management, we aimed to delineate clinically relevant genomic and pathological features of a large panel of PSC‐associated BTC (PSC‐BTC).

Approach and Results
We analyzed formalin‐fixed, paraffin‐embedded tumor tissue from 186 patients with PSC‐BTC from 11 centers in eight countries with all anatomical locations included. We performed tumor DNA sequencing at 42 clinically relevant genetic loci to detect mutations, translocations, and copy number variations, along with histomorphological and immunohistochemical characterization. Regardless of the anatomical localization, PSC‐BTC exhibited a uniform molecular and histological characteristic similar to extrahepatic cholangiocarcinoma. We detected a high frequency of genomic alterations typical of extrahepatic cholangiocarcinoma, such as TP53 (35.5%), KRAS (28.0%), CDKN2A (14.5%), and SMAD4 (11.3%), as well as potentially druggable mutations (e.g., HER2/ERBB2). We found a high frequency of nontypical/nonductal histomorphological subtypes (55.2%) and of the usually rare BTC precursor lesion, intraductal papillary neoplasia (18.3%).

Conclusions
Genomic alterations in PSC‐BTC include a significant number of putative actionable therapeutic targets. Notably, PSC‐BTC shows a distinct extrahepatic morpho‐molecular phenotype, independent of the anatomical location of the tumor. These findings advance our understanding of PSC‐associated cholangiocarcinogenesis and provide strong incentives for clinical trials to test genome‐based personalized treatment strategies in PSC‐BTC.
Changing health workforce attitudes to promote improved physical health in mental health service users: Keeping our Staff in Mind (KoSiM)
Authors: Rosenbaum Simon , Ward Philip B. , Baldeo Rishi , Fibbins Hamish , Jarman Rebecca , Lederman Oscar , Perram Amy , Poole Josephine , Rossimel Elisa , Smith Gabriella , Teasdale Scott , Wade Tammy , Watkins Andrew , White Annette , Pearce David , Curtis Jackie 
Published: January 2020

AbstractIssue addressedPeople living with mental illness die on average 15 years earlier than the general population, primarily due to preventable and premature cardiovascular disease. Lifestyle interventions can be effective in reducing cardiovascular risk, yet mental health services do not routinely provide targeted lifestyle interventions. Exposing mental health staff to lifestyle interventions prior to targeting patients may be critical to changing culture and improving patient outcomes. This study aimed to improve the physical health of mental health staff through a targeted lifestyle intervention.MethodsA pragmatic single‐arm intervention study was conducted in a public mental health service, including inpatient and community settings, in Sydney, Australia. Participants in this study were n = 212 clinical and non‐clinical staff. A five‐session individualised lifestyle intervention (delivered over 5 weeks) incorporating physical activity and nutritional counselling was delivered by multidisciplinary teams. Participants were assessed at baseline, following the intervention, and at follow‐up (mean = 16.7 weeks). The primary outcome was the barriers, attitudes, knowledge and confidence regarding screening, promoting and intervening to improve physical health outcomes of patients (M‐BACK questionnaire). Secondary outcomes included anthropometric measures, cardiorespiratory fitness, sedentary time and nutritional intake. Repeated measures ANCOVAs were performed.ResultsA total of 212 staff (79% female) participated in this study. M‐BACK total score significantly increased from baseline to follow‐up (P < .001). Waist circumference, sedentary time and total energy intake all significantly decreased (all P's < .001) and cardiorespiratory fitness significantly increased (P < .001).ConclusionA brief lifestyle intervention for staff of a public mental health service may increase the capability of the participants to improve their own physical health.So what?Improving staff health may be an important strategy in improving the uptake and/or the effectiveness of lifestyle interventions targeting mental health service users.
Numerical solution of the onset of Buoyancy‐driven nanofluid convective motion in an anisotropic porous medium layer with variable gravity and internal heating
Authors: Yadav Dhananjay 
Published: January 2020

AbstractThe onset of buoyancy‐driven convective motion in a nanofluid saturated anisotropic porous medium layer is examined numerically in the occurrence of uniform internal heat source under the variable gravity field. Three kinds of gravity force variation functions: (a) G(z) = −z (linear), (b) G(z) = −z2 (parabolic), and (c) G(z) = −z3 (cubic) are considered. Wide‐range governing parameters impacts are inspected on the beginning of convective motion under the zero nanoparticle flux situation at the boundaries using the higher term Galerkin technique. It is established that the thermal anisotropy parameter η and the gravity variation parameter λ delay the arrival of convective motion, while the mechanical anisotropy parameter ξ, the internal heating parameter Hs, the nanoparticle Rayleigh‐Darcy number Rnp, the modified diffusivity ratio NAnf, and the modified nanofluid Lewis number Lenf rapid the start of convective motion. The size of the convective cells reduces on raising the internal heating parameter Hs, while the gravity variation parameter λ, the mechanical anisotropy parameter ξ, the thermal anisotropy parameter η, the nanoparticle Rayleigh‐Darcy number Rnp, the modified diffusivity ratio NAnf, and the modified nanofluid Lewis number Lenf amplify the dimension of the convective cells. It is also detected that the arrangement is more unstable for case (c), while it is more stable for case (a).
Comparison of the accuracy and reliability of the AmniSure, AMNIOQUICK, and AL‐SENSE tests for early diagnosis of premature rupture of membranes
Authors: Elçi Erkan , Güneş Elçi Gülhan , Sayan Sena 
Published: January 2020

AbstractObjectiveTo compare the accuracy and reliability of the AmniSure, AMNIOQUICK, and AL‐SENSE tests with conventional tests to diagnose suspected premature rupture of membranes (PROM).MethodsA prospective cohort study of 60 pregnant women at 25–36 weeks of pregnancy with suspected PROM was conducted between January and April 2015. AmniSure (Qiagen Sciences LLC, Germantown, MD, USA), AMNIOQUICK (BIOSYNEX, Strasbourg, France), and AL‐SENSE (Common Sense Ltd, Caesarea, Israel) tests were performed after conventional tests (ultrasonography, pooling, nitrazine, and fern tests) and women were followed‐up for 7 days. Sensitivity, specificity, and diagnostic accuracy, among others, were assessed and compared.ResultsFor women with a confirmed diagnosis of PROM, the sensitivity and specificity of conventional tests were 93.7% and 100.0%, respectively; diagnostic accuracy was 98.3%. Sensitivity, specificity, and diagnostic accuracy were all 100.0% for AmniSure. Sensitivity, specificity, and diagnostic accuracy for AMNIOQUICK were 75.0%, 97.7%, and 91.6%, respectively. Sensitivity, specificity, and diagnostic accuracy were 75.0%, 86.3%, 83.3%, respectively, for the AL‐SENSE pad test.ConclusionThe AmniSure test was most sensitive and specific for diagnosing PROM compared with the other tests and is reliable and usable.
Changes in perinatal outcomes after implementation of IADPSG criteria for screening and diagnosis of gestational diabetes mellitus: A national survey
Authors: Lucovnik Miha , Steblovnik Lili , Verdenik Ivan , Premru‐Srsen Tanja , Tomazic Marjeta , Tul Natasa 
Published: January 2020

AbstractObjectiveTo compare perinatal outcomes before and after implementation of the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria for testing of gestational diabetes mellitus (GDM).MethodsA national, perinatal, registry‐based cohort study of prospectively collected data was conducted. Patients with diabetes type 1 or 2 were excluded. Outcomes of 135 786 pregnancies before (January 1, 2004 to May 31, 2010) and 140 524 after (June 1, 2011 to December 31, 2017) the introduction of IADPSG criteria were compared using Student t test and χ2 test (P<0.05 was significant). Multivariable logistic regression was used to compare outcomes controlling for potential confounders.ResultsPrevalence of GDM increased from 2.6% to 9.7% (adjusted odds ratio 3.92; 95% confidence interval 3.78–4.08). Incidence of large‐for‐gestational age (LGA), macrosomia (birth weight >4500 g), Erb's palsy, and hypertensive disorders in pregnancy decreased despite increasing maternal age and pre‐pregnancy obesity. Rates of cesarean delivery increased in both GDM and non‐GDM groups, with a less pronounced increase in GDM mothers. Incidence of small‐for‐gestational age (SGA) increased in GDM but not in non‐GDM group.ConclusionImplementation of IADPSG criteria in a country with a relatively low prevalence of GDM did not result in higher rates of cesarean delivery and was associated with reductions in LGA and hypertensive disorders in pregnancy.
Challenges for Autonomous Vehicles (AVs) Engineering: Safety Validation of Functional Performance Limitations
Authors: Koné Tchoya Florence , Bonjour Eric , Levrat Eric , Mayer Frédérique , Géronimi Stéphane 
Published: January 2020

ABSTRACTAVs engineering cannot limit itself to the classical safety validation issue, which ensures the vehicle's functional safety. It faces a new safety validation challenge, in the functional performace guarantee of these new vehicle types. This paper presents some validation issue reflections and concludes with some important questions.
Evaluation of Systems Contractor's Ability to Deliver a Solution to Offer During an Engineer‐To‐Order Bidding Process
Authors: Sylla Abdourahim , Vareilles Elise , Coudert Thierry , Aldanondo Michel , Geneste Laurent 
Published: January 2020

ABSTRACTTo increase their business volume and remain competitive, systems contractors must propose competitive and feasible solutions to customers. However, Engineer‐To‐Order industrial situations become challenged by the lack of relevant information. This article, to help companies to overcome this problem, presents two confidence indicators, their evaluation methods, and a way to use them during a design process. These indicators allow evaluating a company's future ability to offer a solution during a bidding process.
In vitro and in vivo metabolic stability of various fragrance materials and insect repellent in rainbow trout (Oncorhynchus mykiss)
Authors: Weeks John , Guiney Patrick , Johanning Karla 
Published: January 2020

AbstractCommercial fragrances consist of several thousand natural and synthetic substances formulated in complex combinations. These ingredients are frequently blended at very low concentrations but they are typically lipophilic and a few of them (e.g., synthetic musks) have been detected in aquatic systems, albeit at low concentrations. Few fragrances have guideline in vivo data on bioaccumulation, so in silico modeling has been widely used to estimate bioconcentration factors (BCFs). This study used in vitro metabolism assays with trout S9 cell fractions and cryopreserved hepatocytes to improve estimates of fish BCFs and to test published methods for extrapolating in vitro metabolic rate data to whole fish and corresponding BCFs. These estimates for several chemicals were compared with new in vivo bioconcentration measurements and previously published data on fragrances and the insect repellent, DEET. In total, 17 (20 including isomers) fragrance chemicals (abalyn, amberwood, amboryl acetate, bisabolene, cedroxide, coniferan, elemol, givescone, maritima, precyclemone B, polysantol, sandela, sanjinol, santalex, timberol and vernaldehyde) and DEET were metabolized at various rates. Only three materials tested did not appear to undergo enzymatic degradation (caryophyllene oxide, galaxolide and ketone patchouli). Even relatively slow rates of metabolism had a large influence on bioconcentration estimates. This work adds valuable information to the evolving body of work supporting the use of in vitro determinations of hepatic clearance to improve modeled predictions of bioaccumulation. It can also be used directly to help prioritize testing of potential bioaccumulative chemicals or serve as a more economical method for screening these chemicals.
Development of antibacterial, ciprofloxacin‐eluting biodegradable coatings on Ti6Al7Nb implants to prevent peri‐implant infections
Authors: Jaworska Joanna , Jelonek Katarzyna , Jaworska‐Kik Marzena , Musiał‐Kulik Monika , Marcinkowski Andrzej , Szewczenko Janusz , Kajzer Wojciech , Pastusiak Małgorzata , Kasperczyk Janusz 
Published: January 2020

AbstractVarious types of biodegradable polymers containing lactide, glycolide, caprolactone, and trimethylene carbonate units have been used to obtain ciprofloxacin (CFX)‐enriched coatings developed on the Ti6Al7Nb alloy, intended for short‐term therapy. In the first step, the surface of the Ti6Al7Nb alloy was modified, mostly according to sandblasting and anodic oxidation to obtain the TiO2 layer. Anodizing can be an effective method for preparing TiO2 coatings with osteoconductive properties. The polymer containing CFX molecules was deposited on the modified alloy, and Polymer + CFX/TiO
2/Ti6Al7Nb systems were developed. CFX‐enriched coatings adhered well to the surface of the previously modified alloy. Polymer layers maintain the topography of the alloy due to the development of the surface during the sandblasting method. As polymers intended for the study possess degradation ability, they are capable of releasing the incorporated drug. Antibacterial activity of CFX‐enriched coatings was examined to verify the functionality of designed Polymer + CFX/TiO
2/Ti6Al7Nb systems, and the bactericidal effect was confirmed for all cases. The presented study is an extension of previous, initial research and creates an overview of polyester or polyestercarbonate CFX‐eluting coatings.