bluuebunny/crossref_metadata_2025_split huggingface dataset:
Possible Enhancement of Photodynamic Therapy (PDT) Colorectal Cancer Treatment when Combined with Cannabidiol
Authors: Nkune Nkune W. , Kruger Cherie A. , Abrahamse Heidi 
Published: April 2020

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Colorectal cancer (CRC) has a high mortality rate and is one of the most difficult diseases to manage due to tumour resistance and metastasis. The treatment of choice for CRC is reliant on the phase and time of diagnosis. Despite several conventional treatments available to treat CRC (surgical excision, chemo-, radiation- and immune-therapy), resistance is a major challenge, especially if it has metastasized. Additionally, these treatments often cause unwanted adverse side effects and so it remains imperative to investigate, alternative combination therapies.
Photodynamic Therapy (PDT) is a promising treatment modality for the primary treatment of CRC, since it is non-invasive, has few side effects and selectively damages only cancerous tissues, leaving adjacent healthy structures intact. PDT involves three fundamentals: a Photosensitizer (PS) drug localized in tumour tissues, oxygen and light. Upon PS excitation using a specific wavelength of light, an energy transfer cascade occurs, that ultimately yields cytotoxic species, which in turn induces cell death. Cannabidiol (CBD) is a cannabinoid compound derived from the Cannabis sativa plant, which is found to exert anticancer effects on CRC through different pathways, inducing apoptosis and so inhibits tumour metastasis and secondary spread.
This review paper highlights current conventional treatment modalities for CRC and their limitations, as well as discusses the necessitation for further investigation into unconventional active nanoparticle targeting PDT treatments for enhanced primary CRC treatment. This can be administered in combination with CBD, to prevent CRC secondary spread and so enhance the synergistic efficacy of CRC treatment outcomes, with less side effects.
Fluid Administration in Emergency Room Limited by Lung Ultrasound in Patients with Sepsis: Protocol for a Prospective Phase II Multicenter Randomized Controlled Trial
Authors: Mohamed Mouhand F H , Malewicz Nathalie M , Zehry Hanan Ibrahim , Hussain Dina A Monim , Barouh Judah Leão , Cançado Adriana V , Silva Jeancarllo Sousa , Suwileh Salah , Carvajal Jose Retamal 
Published: April 2020

Background
Sepsis remains a major health challenge with high mortality. Adequate volume administration is fundamental for a successful outcome. However, individual fluid needs differ between patients due to varying degrees of systemic vasodilation, circulatory flow maldistribution, and increased vascular permeability. The current fluid resuscitation practice has been questioned. Fluid overload is associated with higher mortality in sepsis. A sign of fluid overload is extravascular lung water, seen as B lines in lung ultrasound. B lines correlate inversely with oxygenation (measured by a ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen ie, PaO2/FiO2). Thus, B lines seen by bedside ultrasound may have a role in guiding fluid therapy.

Objective
We aim to evaluate if fluid administration guided by lung ultrasound in patients with sepsis in emergency departments will lead to better oxygenation and patient outcomes than those in the standard therapy.

Methods
A phase II, multicenter, randomized, open-label, parallel-group, superiority trial will be performed. Patients will be recruited at emergency departments of the participating centers. A total of 340 patients will be randomly allocated to the intervention or standard-of-care group (30mL/kg). The intervention group will receive ultrasound-guided intravenous fluid until 3 B lines appear. The primary outcome will be oxygenation (measured as PaO2/FiO2 ratio) at 48 hours after starting intravenous fluid administration. Secondary outcomes will be patients’ outcome parameters, including oxygenation after 15 mL/kg fluid at 6, 12, 24, and 48 hours; sepsis progress through Sequential Organ Failure Assessment (SOFA) scores; pulmonary edema evaluation; and 30-day mortality.

Results
The trial will be conducted in accordance with the Declaration of Helsinki. Institutional review board approval will be sought after the participating sites are selected. The protocol will be registered once the institutional review board approval is granted. The trial duration is expected to be 1.5-2.5 years. The study is planned to be performed from 2021 to 2022, with enrollment starting in 2021. First results are expected in 2022. Informed written consent will be obtained before the patient’s enrollment in the study. An interim analysis and data monitoring will ensure the patient safety. The results will be published in a peer-reviewed journal and discussed at international conferences.

Conclusions
This is a protocol for a randomized control trial that aims to evaluate the role of bedside ultrasound in guiding fluid therapy in patients with sepsis via B lines evaluation.

International Registered Report Identifier (IRRID)
PRR1-10.2196/15997
Detecting and Filtering Immune-Related Adverse Events Signal Based on Text Mining and Observational Health Data Sciences and Informatics Common Data Model: Framework Development Study
Authors: Yu Yue , Ruddy Kathryn , Mansfield Aaron , Zong Nansu , Wen Andrew , Tsuji Shintaro , Huang Ming , Liu Hongfang , Shah Nilay , Jiang Guoqian 
Published: April 2020

Background
Immune checkpoint inhibitors are associated with unique immune-related adverse events (irAEs). As most of the immune checkpoint inhibitors are new to the market, it is important to conduct studies using real-world data sources to investigate their safety profiles.

Objective
The aim of the study was to develop a framework for signal detection and filtration of novel irAEs for 6 Food and Drug Administration–approved immune checkpoint inhibitors.

Methods
In our framework, we first used the Food and Drug Administration’s Adverse Event Reporting System (FAERS) standardized in an Observational Health Data Sciences and Informatics (OHDSI) common data model (CDM) to collect immune checkpoint inhibitor-related event data and conducted irAE signal detection. OHDSI CDM is a standard-driven data model that focuses on transforming different databases into a common format and standardizing medical terms to a common representation. We then filtered those already known irAEs from drug labels and literature by using a customized text-mining pipeline based on clinical text analysis and knowledge extraction system with Medical Dictionary for Regulatory Activities (MedDRA) as a dictionary. Finally, we classified the irAE detection results into three different categories to discover potentially new irAE signals.

Results
By our text-mining pipeline, 490 irAE terms were identified from drug labels, and 918 terms were identified from the literature. In addition, of the 94 positive signals detected using CDM-based FAERS, 53 signals (56%) were labeled signals, 10 (11%) were unlabeled published signals, and 31 (33%) were potentially new signals.

Conclusions
We demonstrated that our approach is effective for irAE signal detection and filtration. Moreover, our CDM-based framework could facilitate adverse drug events detection and filtration toward the goal of next-generation pharmacovigilance that seamlessly integrates electronic health record data for improved signal detection.
Penerapan Military Confi dence Building Measures dalam Menjaga Ketahanan Nasional Indonesia di Ruang Siber
Authors: Chotimah Hidayat Chusnul , Iswardhana Muhammad Ridha , Pratiwi Tiffany Setyo 
Published: April 2020

ABSTRACT This research discussedimplementation of military confidence building in responding various threats that may arised in Indonesian cyber sovereignty. This study used qualitative approach with data collection through literature study and in-depth interviews namely Director for International Security and Disarmament Ministry of Foreign Affairs of The Republic of Indonesia, Deputy of Protection National Cyber and Crypto Agency of the Republic of Indonesia (BSSN), and Ministry of Communications and Informatics of the Republic of Indonesia. The results showed that implementation of military confidence building to upheld national resilence in cyberspace consisted of three aspects, namely the exchange of information and communication, transparency and verification, and military restraint in the field of cyber.ABSTRAK Penelitian ini membahas penerapan military confidence building dalam merespon berbagai ancaman yang mungkin timbul di ranah kedaulatan siber Indonesia.Pendekatan yang digunakan dalam penelitian ini yaitu melalui pendekatan kualitatif dengan teknik pengumpulan data melalui studi pustaka dan wawancara mendalam dengan Direktorat Jenderal Kerja Sama Multilateral Kementerian Luar Negeri Republik Indonesia sub bagian Direktorat Keamanan Internasional dan Perlucutan Senjata Kementerian Luar Negeri, Badan Siber dan Sandi Negara (BSSN) Deputi Bidang Proteksi dan Kementerian Komunikasi dan Informatika Republik Indonesia.Hasil penelitian menunjukkan bahwa penerapan military confidence building untuk menegakkan ketahanan nasional di ruang siber dilakukan melalui tiga aspek yaitu pertukaran informasi dan komunikasi, transparansi dan verifikasi, dan pembatasan militer (military restraint) di bidang siber.
Diversity and Distribution of Herpetofauna in Banyu Nibo Waterfall Ecotourism Region, Nglanggeran, Gunung Kidul, Special Region of Yogyakarta
Authors: Saputro Alfonsus Toribio Eko , Boscha Elika , Nainggolan Ananto Puradi , Yudha Donan Satria , Eprilurahman Rury 
Published: April 2020

Banyu Nibo Waterfall is located near Nglanggeran, Gunung Kidul that well known for its eco-tourism development. The geographical and ecosystem condition could be providing unique habitat for herpetofauna. Herpetofauna has important role in the ecosystem as food chain components and even as environment bioindicator.The aim of this research is to asses the herpetofauna diversity in Banyu Nibo Waterfall as preliminary biodiversity data. The research was conducted using VES (Visual Encounter Survey) assisted by 500 meters transect line. As a result, 15 species were found, mainly distributed on area with tree coverage.
THE SIGNIFICANCE OF CHILDREN’S FOLK DANCES ACCOMPANIED BY SINGING IN THE PROCESS OF MUSIC TRADITION CONSERVATION AND FOSTERING
Authors: Stojadinović Aleksandar 
Published: April 2020

The crucial point this thesis is trying to answer is what concrete and practical possibilities there are nowadays in contemporary music culture teaching in the lower classes of primary school in order to implement and use children’s folk dances accompanied by singing, as well as what the aims, tasks and procedures are in the process of conservation and fostering of this form of national tradition. A teacher as a leader of the whole teaching process should tend to provoke joy, willingness and wish in his/her pupils to learn and practice children’s folk dances accompanied by singing, which can have an important impact on establishing a positive attitude to the values of traditional culture and art.
STRATEGY FOR EFFECTIVE MEASUREMENT OF HAND TRANSMITTED VIBRATION AT THE WORKPLACE
Authors: Golubović-Bugarski Valentina , Todic Mladen , Vranjes Biljana 
Published: April 2020

This paper shows the stages in the evaluation of vibration exposure and they involve the following steps: identification of a series of discrete operations which make up the subject’s normal working pattern, selection of operations to be measured, organization and duration of the measurement, estimation of daily vibration exposure time, measurement equipment, location and attachment of the accelerometers, measurement of vibration magnitude, sources of uncertainty in vibration measurement, calculation of daily vibration exposure. In addition, one example of the calculation of daily vibration exposure of workers employed in the “DalCin” d.o.o. Company has been presented here.
Corrigendum QUALITATIVE ANALYSIS OF GLASS FIBRE FILTER AND RESPIRABLE FOAM USING X-RAY FLUORESCENCE
Authors: Živković Nenad 
Published: April 2020

CorrigendumThompson Faraday Ediagbonya1, S.A. Uzoekwe2, H. Ayedun1QUALITATIVE ANALYSIS OF GLASS FIBRE FILTER AND RESPIRABLE FOAM USING X-RAY FLUORESCENCE 1Chemical Sciences, Ondo State University of Science and Technology, Okitipupa, Nigeria2Chemical Sciences Department, Federal University Utuoke, Bayelsa, Nigeria FACTA UNIVERSITATIS, Series Working and Living Environmental Protection Vol. 13, No 3, 2016, pp. 215 -223, DOI: 10.22190/FUWLEP1603215E The Editor-in-Chief has been informed that in the article ‘Qualitative Analysis of Glass Fibre Filter and Respirable Foam Using X-Ray Fluorescence’, FACTA UNIVERSITATIS, Series Working and Living Environmental Protection Vol. 13, No 3, 2016, pp. 215-223, DOI: 10.22190/FUWLEP1603215E, co-author’s names - S.A. Uzoekwe, H. Ayedun - have been omitted. After further discussion with the corresponding author, the Editor-in-Chief has decided to publish a corrigendum for this article. Link to the corrected article - DOI: 10.22190/FUWLEP1603215E
¿Cómo entender información especializada del COVID-19?
Authors: Catalá Rosa María , Palacios-Arreola Isabel , Martínez Vázquez Ana 
Published: April 2020

<p class="p1">Esta hoja didáctica acompaña al artículo titulado <em>El origen de COVID-19: lo que se sabe, lo que se supone y (muy poquito) sobre las teorías de complot.<span class="Apple-converted-space"> </span></em> La idea es conducir a los estudiantes en la lectura, haciendo uso de palabras y conceptos que pueden reconocer o que podemos hacer que recuerden. Los alumnos y las alumnas harán modelos sencillos que les permitirán entender parte de la información.</p>
Comprensión didáctica del currículo como espacio público
Authors: Fernández Betsi 
Published: April 2020

El presente estudio, referido a la dinámica curricular del siglo XXI en la Universidad Pedagógica Experimental Libertador (UPEL), en Venezuela, tiene como propósito generar criterios para la comprensión didáctica y contextual del currículo como espacio público en la institución como contribución con la gestión integral del proceso formativo de los ciudadanos, profesionales e investigadores y la distribución del poder en la construcción del diseño curricular de la carrera docente y áreas afines con sentido social, cultural, histórico y ético. Los propósitos específicos han sido: (a) comprender el conocimiento curricular como producción intelectual condicionada por el contexto social y el momento histórico que vive la UPEL, (b) describir el proceso de legitimación del discurso curricular al concebir el currículo como espacio público, desde el debate de las ideas y los valores contextuales presentes en la UPEL. La investigación está enmarcada en el paradigma naturalista, bajo un enfoque cualitativo, en una modalidad de investigación de campo, descriptiva y documental. Se emplean como técnicas la entrevista y el análisis de contenido y como instrumentos el guion de entrevistas y la matriz de análisis de contenido. Los resultados se analizan cualitativamente, aplicando la triangulación de fuentes para generar los criterios orientadores de la comprensión didáctica y contextual del currículo como espacio público, producto de la investigación.
Agentes educadores y estereotipos sobre masculinidad: reflexiones para la formación de identidades masculinas alternativas.
Authors: Arias Chamorro Juan José , Navarro Verjel Kathy Alejandra , Ortega Garnica Laura Daniela 
Published: April 2020

Antecedentes. Estudios preliminares relacionados con el patriarcado, la hegemonía, las masculinidades alternativas y los contextos socializadores de representaciones acerca de lo masculino fortalecen el propósito de la revisión teórica planteada. Objetivo. Analizar la construcción de la masculinidad en relación con la socialización de los diferentes agentes educadores. Métodos. Se ha llevado a cabo una revisión sistemática de 50 documentos que abordan el tema “Masculinidad”. Resultados. Se presentan la construcción de la masculinidad de acuerdo a la existencia de modelos tradicionales o nuevos, así mismo de los espacios relacionales que socializan y reproducen el deber ser de hombres y mujeres, en esencia la familia, la escuela/colegio y la universidad. Conclusión. Se infiere que la masculinidad y su construcción se conceptualiza desde la hegemonía y la alternatividad, siendo los agentes educadores transmisores culturales de lo que debe significar la masculinidad.
The other side of fieldwork: experiences and challenges of conducting research in the border area of Rwanda/eastern Congo
Authors: Begley Larissa 
Published: April 2020

This paper will explore various experiences and challenges that have occurred during my ongoing fieldwork. Beginning in March 2008 and continuing until October, fieldwork for this research has taken place in the border region of Rwanda and the eastern Democratic Republic of the Congo (DRC), specifically in the cities of Cyangugu and Gisenyi, Rwanda, and to a lesser extent Goma and Bukavu, DRC. Most anthropologists in the field will experience feelings of isolation and loneliness. However, the current conditions of this region, which remains a conflict zone under tight government control, add another dimension. This has contributed to further feelings of isolation, frustration, fear, distrust, insecurity, and with no clear way to seek support for both the informants and the anthropologist. This paper will address these challenges and the ways that they impact on the research process itself, as well as the effects they have on the anthropologist.
PERKEMBANGAN OBJEK WISATA DI KABUPATEN LIMA PULUH KOTA
Authors: Roli M , Aziz Ahyuni , Syahar Fitriana 
Published: April 2020

Penelitian ini membahas tentang perkembangan objek wisata di Kabupaten Lima Puluh Kota. Tujuan penelitian ini untuk melihat perkembangan objek wisata di Kabupaten Lima Puluh Kota sesuai dengan Teori Butler tahun 1980 dari Model Tourism Area Life Cycle ( TALC)
Jenis penelitian ini adalah penelitian deskriptif dengan menggunakan metode kuantitatif. Sampel penelitian ini adalah objek wisata andalan Kabupaten Lima Puluh Kota yaitu Objek Wisata Lembah Harau, Objek Wisata Batang Tabik, Objek Wisata Pusako Rumah Gadang, dan Objek Wisata Kapalo Banda. Jenis analisi data yang digunakan adalah analisis data sekunder (ADS) dan Scoring Model dari Gunn dan Model TALC sebagai alat ukur dalam penelitian yaitu perkembangan objek wisata ditahap Eksplorasi (exploration), Tahap keterlibatan (involvemento), Tahap Pengembangan (development), Tahap Konsolidasi (Consolidation), Tahap kestabilan (stagnation), Tahap penurunan kualitas (decline), dan Tahap peremajaan kembali (rejuvenate). Data yang diolah yaitu data sekunder yang didapatkan dari Dinas Pariwisata, Pemuda dan Olahraga, Dinas Pekerjaan Umum, dan Badan Pusat Statistik Kabupaten Lima Puluh Kota.
Hasil temuan peneliti diperoleh: 1) Tahap perkembangan objek wisata ditinjau dari aspek jumlah kunjungan dan sarana prasarana yaitu a) Objek Wisata Lembah Harau berada di Tahap Kestabilan (Stagnation), b) Objek Wisata Batang Tabik berada pada Tahap Konsolidasi (Consolidation), c) Objek Wisata Pusako Rumah Gadang berada pada Tahap Penurunan Kualitas ( Decline), d) Objek Wisata Kapalo Banda berada pada Tahap Keterlibatan (Involvement). 2) Jumlah kunjungan wisatawan dari tahun 2007 sampai 2014 terbanyak terjadi di Objek Wisata Lembah Harau 1.023.617 jiwa dan perkembangan sarana prasarana dengan skor 4,8, Objek Wisata Kapalo Banda 499.612 jiwa dan perkembangan sarana prasarana dengan skor 2,2, Objek Wisata Batang Tabik 447.096 jiwa dan perkembangan sarana prasarana dengan skor 3,2 , Objek Wisata Pusako Rumah Gadang 9.708 dan perkembangan sarana prasarana dengan skor 4. Dapat disimpulkan perkembangan objek wisata di Kabupaten Lima Puluh Kota masih butuh perhatian khusus seperti kegiatan pemberdayaan SDM yang berkualis agar pengelolaan terlaksana dengan baik serta pemeliharaan sarana prasarana agar objek wisata tersebut dapat berkontribusi terhadap pembangunan daerah Kabupaten Lima Puluh Kota, baik bagi pemerintah maupun masyarakat
IDENTIFIKASI FISIK BUMI UNTUK MEMETAKAN SUMBER – SUMBER BELAJAR BERBASIS LINGKUNGAN DI KABUPATEN TANAH DATAR
Authors: Putra Gerry Oktaviano , Anwar Syafri , Hermon Dedi 
Published: April 2020

Penelitian ini bertujuan untuk memperoleh data tentang Identifikasi Fisik Bumi untuk Memetakan Sumber – Sumber Belajar Berbasis Lingkungan di Kabupaten Tanah Datar. Jenis Penelitian adalah deskriptif dengan metode kualitatif. Penelitian dilakukan di lingkungan dan SMAN/MAN di daerah Kabupaten Tanah Datar. Sampel dalam penelitian adalah fisik muka bumi yang ada di Kabupaten Tanah Datar. Sampel diambil secara purposive sampling. Teknik pengumpulan data dengan observasi. Teknik analisis data dengan menggunakan Google Earth dan ArcGIS.
Hasil penelitian menunjukkan bahwa Di Kabupaten Tanah Datar terdapat beragam jenis dan persebaran fisik muka bumi yang dapat dijadikan sumber belajar yang berbasis lingkungan diantaranya (1) Sungai (Batang Anai, Batang Selo, Batang Sinamar, Batang Ombilin, dan Batang Sumpur). (2) Danau (Danau Singkarak). (3) Gunung (Marapi, Singgalang, dan Sago). (4) Gua (Ngalau Pangean). (5) Telaga (Telaga Koto Baru, Kayu Tanduak, Aia Taganang). (6) Air Terjun (Lembah Anai). 2. Berdasarakan pemetaan, kondisi fisik di Kabupaten Tanah Datar layak di jadikan sumber belajar, karena kriteria pemilihan sumber belajar dan aspek lainnya mendukung untuk menjadikan sumber belajar mata pelajaran geografi SMA/MA kelas X SK (Menganalisis unsur-unsur Geosfer) KD 3.1 (menganalisis dinamika & kecenderungan perubahan litosfer dan pedosfer serta dampaknya terhadap kehidupan di muka bumi) dan 3.3 (Menganalisis hidrosfer dan dampaknya terhadap kehidupan di muka bumi)
ANALISIS PERTUMBUHAN PENDUDUK TERHADAP PERUBAHAN PENGGUNAAN LAHAN DI KOTA BUKITTINGGI
Authors: Mariya Sri 
Published: April 2020

Bukitinggi city is the most populous city in West Sumatra, experiencing an increase in population from year to year, the limitations of urban space that causes pressure on urban space. Such as the occurrence of land conversion for the physical construction of the city, such as: settlement, trade and services, and others. Based on this research, the aim of this study is to obtain information, discuss and analyze (1) population growth of Bukittinggi City in 2000-2010, (2) to identify land use change of Bukitinggi city in 2000-2010, and (3) to identify the characteristics of change Land use due to population growth and how the utilization of Bukitinggi City space.
The type of research used is descriptive research with secondary data analysis method with the support of Geographic Information System (GIS). The data used are population data of Bukittinggi City 10 years (2000-2010), Land Use Map of Bukit Tinggi City (2000 and 2010), and Map of RTRW Kota Bukitinggi 2010 as final analysis.
The results showed that: (1) the population growth of Bukittinggi City in 2000-2010 was 0.02 or 2% which indicated an increase in population. The dominant factor that affects is migration (residents coming). The most populous urban village is Sapiran 12orang / km2 which is the center of TNI and Polri dormitory, while the urban village is Puhun Pintu Kabun with density of 2 person / km2, (2) land use change in settlement, rice field, mixed or moorland, Services. The largest expansion occurred from mixed or cultivated gardens of 1.75 km2. Other changes occurred in the settlement of 0.06 km2 and trade and services 0.14 km2. (3) Characteristics of land use change due to population growth in relation to spatial use dominated by mixed or mooring farms into 6.89% (174.6 ha) settlements, rice fields became 0.25% (6.4 ha) settlements, and rice fields became Mixed garden 0.55% (14 ha). Linkages to the use of space is the study of green space: Park City, Village Pintu Kabun and Bukit Apit there is development of settlements as the development of the area towards the north which needs to be done policy priorities.