bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating ErbB3/HER3 Levels are Associated with Increased Risk of Hypertension With Overweight: A Cross-Sectional Study
Authors: Zhu Lijun , Fang Zhengmei , Jin Yuelong , Chang Weiwei , Huang Mengyun , Chen Yan , Yao Yingshui 
Published: October 2020

Abstract
Background: Hypertension and overweight are both independent risk factors for cardiovascular disease，and being overweight can more likely to develop high blood pressure. Recent research has shown that ErbB3/HER3 played a considerable role in the development of cardiovascular disease. However, ErbB3 levels effects in the hypertensive overweight patients are unknown. This study aimed to assess the association between ErbB3 levels and hypertension with overweight in Chinese population.Methods: 128 Chinese adults aged 33-79 years, both sexes, underwent evaluation of height and weight, blood pressure, biochemical indicators and ErbB3 levels. Plasma ErbB3 levels was assessed by the Enzyme-linked immunosorbent assay (ELISA), and body mass index (BMI) was calculated as body weight divided by height squared. Participants were allocated in three groups according to blood pressure and BMI: healthy control group (CNT; n = 31; normotensive and nonoverweight), hypertension group (HT; n = 33; hypertension and nonoverweight) and hypertension with overweight group (HTO; n = 64; hypertension and overweight). A 2-tailed P<0.05 was defined to be statistically significant.Results: The difference in mean of ErbB3 levels in three groups was not significant, but had a linear decrease in males, in CNT (1.13±0.36), HT (1.03±0.36) and HTO (0.84±0.26) ng/ml, with P was 0.007. In drinking population, the ErbB3 was significantly reduced in the HTO group as compared with the CNT and HT groups (0.76±0.23 versus 1.18±0.37 and 1.20±0.30, respectively). ErbB3 levels was negatively correlated with DBP in males(r=-0.293, P=0.012), in smoking populations (r=-0.47, P=0.004) and drinking populations (r=-0.387, P=0.008). Besides, BMI in males and in drinking populations and UA in males presented negatively correlations with ErbB3 (p＜0.05). The multivariate conditional logistic regression showed that plasma ErbB3 levels was associated with reduced risk for HTO in males (OR 0.054; 95% CI: 0.007-0.412) and drink group(OR 0.002; 95% CI: 0.000-0.101).Conclusions：The apparent association between lower ErbB3 levels and overweight hypertensive patients suggested that ErbB3 may contribute to the pathogenesis to hypertension with overweight, with BMI, gender, and drinking all potentially modulating the process.
Crosslinkable poloxamer in-situ gel as a submucosal cushion for endoscopic submucosal dissection
Authors: Gao Yuan , Huang Chao , Chen Jiyuan , Tai Zongguang , Li Yan , Gao Shen , Wan Xinjian 
Published: October 2020

Abstract
Hypertonic saline solution is used for endoscopic submucosal dissection (ESD) as a submucosal fluid cushion (SFC). However, short duration time and side effects like perforation and bleeding have limited the application of SFC. Here, an in-situ gel crosslinked acrylate/thiol Poloxamer 407 (PA-PSH) was used as an SFC for ESD to avoid perforation, and the feasibility and safety of the PA-PSH for ESD was evaluated in vitro and in vivo. PA-PSH thermal injection led to a longer-lasting elevation with clearer margins as compared with glycerol, with a high mucosal elevation induced by thiol-ene crosslinked acrylate Poloxamer 407 (PA) and thiol-capped Poloxamer 407 (PSH) in physiological conditions. ESD was achieved precisely without obvious adverse effects and tissue damage. The PA-PSH in-situ gel provides an excellent submucosal injection system, which has great potential to improve the ESD technique.
Association of Overall Screen Time and Outdoor Activity with Emotional and Behavioral Health Problems
Authors: Tao Fangbiao , Zhang Yi , Wu Xiaoyan , Wang Qianling , Zong Qiao , Wang Renjie , Li Tingting 
Published: October 2020

Abstract
BackgroundPsychological problems among children and adolescents have become a public health issue. This study aimed to investigate associations between screen time (ST), outdoor activity (OA), and emotional and behavioral health problems (EBHPs) among South Chinese children and adolescents.MethodsA total of 30,188 boys and girls from 14 elementary and junior high schools on six streets in Shenzhen were included in this study. EBHPs were measured with the strengths and difficulties questionnaire; OA and ST data were obtained through self-reporting. Descriptive analyses, chi-square tests, and logistic regressions were performed using SPSS 23.0.ResultsIn our study, 42.4% students had insufficient OA, 24.2% students had excessive ST, the abnormal prevalence of emotional symptoms, conduct problems, peer problems, hyperactivity problems, prosocial behavior, and total difficulties scales were 18.5%, 6.9%, 6.4%, 13.1%, 10.7% and 8.8%. There were significant associations between ST/OA, independent and addictive interaction, and EBHPs among children and adolescents. Participants with high exposure to ST were more likely to have EBHPs than those with low exposure; participants with low exposure to OA were also more likely to have EBHPs than those with high exposure. The interactive associations of ST and OA on EBHPs were stronger than those of ST or OA individually.ConclusionsOur results show positive associations between ST, OA, and EBHPs. They indicate that interventions should be considered for decreasing ST and increasing OA in children and adolescents.
Renal tumors: Age spectrum and histological distribution across childhood
Authors: Liu Tingting , Al-Kzayer Lika’a Fasih Y. , Nakazawa Yozo , chen lei 
Published: October 2020

Abstract
BackgroundThe objective of this study was to identify the relationship between the histopathological distribution of renal tumors and the age parameter across childhood period and to compare that with the available literature.MethodsA total of 193 pediatric patients with renal tumors were classified into 5 groups as embryo, infant, early childhood, childhood, and adolescent. Age distribution, pathological types and clinical characteristics were summarized. ResultsAmong the 193 patients, 95.8% presented with malignant tumors, and 4.2% showed benign tumors. The prevalence of Wilms’ tumor (WT( and non-WT, were 63.7% and 36.3%, respectively. Non-WT patients included clear cell sarcoma of the kidney (CCSK), followed by rhabdoid tumor of the kidney (RTK), congenital mesoblastic nephroma (CMN), cystic partially differentiated nephroblastoma (CPDN), and renal cell carcinoma (RCC). Early childhood (89/193, 46.2%) was the most common period of onset, followed by infant (73/193, 37.9%), childhood (19/193, 9.8%), embryo (8/193, 4.1%) and adolescent (4/193, 2.0%). WT predominantly occurred in infant and early childhood and decreased among older age group. Non-WT occurred various period of onset and rather common during embryo. 10.9% of patients were asymptomatic at the time of diagnosis and that was significantly observed in non-WT (P=0.04). ConclusionsAge of onset is a highly significant factor for pediatric renal tumors. Relationship between age spectrum and pathological characteristics influences distinguishing the histopathological distribution of WT and non-WT.
Genome-centric Portrait of the Microbes’ Cellulolytic Competency
Authors: Wang Yubo , Li Liguan , Xia Yu , Ju Feng , Zhang Tong 
Published: October 2020

Abstract
Background: Neither the abundance of the exo/endoglucanase GH modules nor the taxonomy affiliation is informative enough in inferring whether a genome is of a potential cellulolytic microbe or not. By interpreting the complete genomes of 2642 microbe strains whose phenotypes have been well documented, we are trying to reveal a more reliable genotype and phenotype correlation on the specific function niche of cellulose hydrolysis.Results: By incorporating into the annotation approach an automatic recognition of the potential synergy machineries, a more reliable prediction on the corresponding microbes’ cellulolytic competency could be achieved. The potential cellulose hydrolyzing microbes could be categorized into 5 groups according to the varying synergy machineries among the carbohydrate active modules/genes annotated. Results of the analysis on the 2642 genomes revealed that some cellulosome gene clusters were in lack of the surface layer homology module (SLH) and microbe strains annotated with such cellulosome gene clusters were not certainly cellulolytic. Hypothesized in this study was that cellulosome-independent genes harboring both the SLH module (mediate the attachment of the enzymes to the host microbe’s cell surface) and the cellulose-binding carbohydrate binding module (mediate the attachment of the enzymes to the cellulose substrate) were likely an alternative gene apparatus initiating the formation of the cellulose-enzyme-microbe (CEM) complexes; and their role is important especially for the cellulolytic anaerobes without cellulosome gene clusters. Conclusions: In the genome-centric prediction on the corresponding microbes’ cellulolytic activity, recognition of the synergy machineries that include but are not limited to the cellulosome gene clusters is equally important as the annotation of the individual carbohydrate active modules or genes. This is the first time that a pipeline was developed for an automatic recognition of the synergy among the carbohydrate active units annotated. With promising resolution and reliability, this pipeline should be a good add to the bioinformatic tools for the genome-centric interpretations on the specific function niche of cellulose hydrolysis.
Machine learning radiomics for predicting recurrence risk in patients with early-stage invasive breast cancer
Authors: Yao Herui , Yu Yunfang , Ren Wei , He Zifan , Chen Yongjian , Tan Yujie , Liu Jingwen , Li Anlin , Lu Nian , Ouyang Jie , Yang Yaping , Chen Kai , Li Chenchen , Ma Mudi , Li Xiaohong , Zhang Rong , Wu Zhuo , Su Fengxi Su , Hu Qiugen , Xie Chuan-Miao , Song Erwei 
Published: October 2020

Abstract
There are no satisfying approaches to identify high- and low-risk recurrence patients with early-stage breast cancer in current clinical practice. Patients might be overtreated or undertreated due to the inaccurate prediction of recurrence risk. Herein, machine learning magnetic resonance imaging radiomic-based signature that integrates the intratumoral and peritumoral radiomic signatures, and clinicopathological characteristics was developed to classify high- and low-risk recurrence patients and predict recurrence within multicentre cohorts. The radiomic-clinical signature could also discriminate high- from low-risk recurrence patients among different breast cancer molecular subtype, and HR+/Her2-, T1N0M0 stage patients. Furthermore, it was observed that the neoadjuvant chemotherapy improved survival in high-risk Luminal subtype patients compared with the adjuvant chemotherapy. The survival-associated radiomic features also showed the correlation with the immune microenvironment. The radiomic-clinical signature presented the feasibility of predicting recurrence risk and assisting clinical decision-making in early-stage invasive breast cancer patients.
Thermal state and evolving geodynamic regimes of the Meso- to Neoarchean North China Craton
Authors: Sun Guozheng , Liu Shuwen , Cawood Peter , Tang Ming , Hunen Jeroen van , Gao Lei , Hu Yalu , Hu Fangyang 
Published: October 2020

Abstract
Constraining the thickness and geothermal gradient of Archean continental crust are crucial to understanding geodynamic regimes of the early Earth. Archean crust-sourced tonalitic–trondhjemitic–granodioritic gneisses are ideal lithologies for reconstructing the thermal state of early continental crust. Integrating experimental results with petrochemical data from the Eastern Block of the North China Craton allows us to establish temporal–spatial variations in thickness, geothermal gradient and basal heat flow across the block, which we relate to cooling mantle potential temperature and resultant geodynamical regime change from plume dominated in the late Mesoarchean (~2.9 Ga) to plate tectonics with hot subduction in the early to late Neoarchean (~2.7–2.5 Ga). The initiation of plate tectonics might have played an important role in the rapid cooling of the mantle, and thickening and strengthening of the lithosphere, which in turn prompted stabilization of the cratonic lithosphere at the end of Archean.
Control of mammalian brain ageing by the unfolded protein response transcription factor XBP1
Authors: Cabral-Miranda Felipe , Tamburini Giovanni , Martinez Gabriela , Medinas Danilo , Gerakis Yannis , Miedema Tim , Duran-Aniotz Claudia , Ardiles Alvaro , Ibaceta-Gonzalez Cristobal Ibaceta , Sabusap Carleen , Bermedo Francisca , Adamson Stuart , Vitangcol Kaitlyn , Huerta Hernan , Zhang Xu , Nakamura Tomohiro , Sardi Pablo , Lipton Stuart , Kennedy Brian , Matus Julio , Palacios Adrian , Plate Lars , Henriquez Juan Pablo , Hetz Claudio 
Published: October 2020

Abstract
Brain ageing is the main risk factor to develop dementia and neurodegenerative diseases, associated with a decay in the buffering capacity of the proteostasis network. We investigated the significance of the unfolded protein response (UPR), a major signaling pathway to cope with ER stress, to the functional deterioration of the brain during aging. Genetic disruption of the ER stress sensor IRE1α accelerated cognitive and motor decline during ageing. Exogenous bolstering of the UPR by overexpressing an active form of the UPR transcription factor XBP1 restored synaptic and cognitive function, in addition to reducing cell senescence. Proteomic profiling of hippocampal tissue indicated that XBP1s expression attenuated age-related alterations to synaptic function and pathways linked to neurodegenerative diseases. Overall, our results demonstrate that strategies to manipulate the UPR in mammals may sustain healthy brain
ageing.
Keeping up with the Joneses: the Relevance of Duesenberry’s Relative Income Hypothesis in Ethiopia
Authors: Bisset Tazeb , Tenaw Dagmawe 
Published: October 2020

Abstract
Although it was mysteriously neglected and displaced by the mainstream consumption theories, the Duesenberry’s relative income hypothesis seems quite relevant to the modern societies where individuals are increasingly obsessed with their social status. Accordingly, this study aims to investigate the relevance of Duesenberry’s demonstration and ratchet effects in Ethiopia using a quarterly data from 1999/2000Q1-2018/19Q4. To this end, two specifications of relative income hypothesis are estimated using Autoregressive Distributed Lag (ARDL) regression model. The results confirm a backward-J shaped demonstration effect. This implies that an increase in relative income induces a steeper reduction in Average Propensity to consume (APC) at lower income groups (the demonstration effect is stronger for lower income households). The results also support the ratchet effect, indicating the importance of past consumption habits for current consumption decisions. In resolving the consumption puzzle, the presence of demonstration and ratchet effects reflects a stable APC in the long-run. Hence, consumption-related policies should be carefully designed as polices aimed at boosting aggregate demand can motivate low income households to gallop into wasteful competition so as to ‘keep up with the Joneses’—the relative riches.
Reconfigurable Multifunctional Ambipolar Polymer Transistors with Improved Switching-off Capability Upon Non-Uniformly Distributed Compensation Potential
Authors: Wei Peng , Wang Xudong , Li Xianglong , Qiao Nan , Han Songyu , Zhang Peng , Deng Yunfeng , Zhang Wei , Bu Laju , Lu Guanghao 
Published: October 2020

Abstract
Ambipolar field-effect transistors allowing both holes and electrons transport can work in different states, which are attractive for simplifying the device manufactures and miniaturizing the integrated circuits. However, conventional ambipolar transistors intrinsically suffer from poor switching-off capability because the gate electrode is not able to simultaneously deplete holes and electrons across the entire transport channel. Here, we show that the switching-off capability of polymer ambipolar transistor is largely improved by up to 3 orders, through introducing non-uniformly distributed compensation potentials along the channel to synchronically tune the charge transport at different channel locations. Non-uniformly gate-stressed conjugated-polymer@insulator blend film induces non-uniformly trapped charges in the insulators, which consequently generates non-uniform compensation electrical field imposed in the conjugated-polymers. Both n-type and p-type operations with high mobility (2.2 and 0.8 cm2s-1V-1 respectively) and high on/off ratio (105) are obtained in the same device, and the device states are reversibly switchable, which provides a new strategy for three-level non-volatile memories and artificial synapses.
Application of 3D printing and framework internal fixation technology for high complex rib fractures
Authors: Zhou Xuetao , Zhang Dongsheng , Xie Zexin , Yang Yang , Chen Menghui , Liang Zheng , Zhang Guoliang , Li Shujun 
Published: October 2020

Abstract
Objective: To explore the clinical effect of 3D printing combined with framework internal fixation technology on the minimally invasive internal fixation of high complex rib fractures.Methods: Total 16 patients with high complex rib fractures were included in the study. Before the procedure, the 3D rib model was reconstructed based on the thin-layer chest CT scan. According to the 3D model, the rib locking plate was pre-shaped, and the preoperative planning were made including the direction of the locking plate, the location of each nail hole and the length of the screw. During the operation, the locking plate was inserted from the sternum to the outermost fracture lines of ribs with screws at both ends. In addition, the locking plate was used as the frame to sequentially reduce the middle fracture segment and fix with screws or steel wires. Chest x-rays or chest CT scans after surgery were used to assess the ribs recovery. All patients were routinely given non-steroidal anti-inflammatory drugs (NSAIDS) for analgesia, and the pain level was evaluated using numerical rating scale (NRS). Results: The preoperative planning according to the 3D printed rib model was accurate. The reduction and fixation of each fracture segment were successfully completed through the framework internal fixation technology. No cases of surgical death, and postoperative chest pain was significantly alleviated. Five to ten months follow up demonstrated neither loosening of screws, nor displacement of fixtures among patients. The lungs of each patients were clear and in good shape.Conclusion: The application of 3D printing combined with framework internal fixation technology to the high complex rib fractures is beneficial for restoring the inherent shape of the thoracic cage, which can realize the accurate and individualized treatment as well as reduces the operation difficulty.
Immune Effective Score As A Predictor Of Response To Neoadjuvant Trastuzumab Therapy And A Prognostic Indicator For HER2-positive Breast Cancer
Authors: Wu Xueying , Zhang Chenyang , Xiong Jing-wei , Zhang Henghui 
Published: October 2020

Abstract
Background: HER2-positive breast cancer (BC) is a highly aggressive phenotype and accounts for 15–20% of all BC cases. The role of the host immune features in predictive response to anti-HER2 therapies and prognosis in BC is already suggested. We aimed to develop a predictive and prognostic model and examine its relevance to the clinical outcomes of patients with HER2-positive BC.Methods: Based on the single-sample gene set enrichment analysis (ssGSEA) scores of the signatures related to neoadjuvant trastuzumab therapy response, an immune effective score (IES) was constructed using principal component analysis algorithms. A bioinformatic analysis using 4 independent cohorts (GSE66305, n=88; GSE130786, n=110; TCGA, n=123; METABRIC, n=236) established associations between IES and clinical outcomes.Results: Genes associated with neoadjuvant trastuzumab therapy response enriched in pathways related to antitumor immune activities, including T cell receptor signaling pathway, Natural killer cell-mediated cytotoxicity and NF−kappa B signaling pathway. IES was demonstrated to be a predictive biomarker to neoadjuvant trastuzumab therapy benefits (GSE66305: area under the curve (AUC) = 0.804; GSE130786: AUC = 0.704). In addition, IES was identified as an independent prognostic factor for overall survival (OS) in the TCGA cohort (P = 0.036, hazard ratio (HR): 0.66, 95% confidence interval (CI): 0.449–0.97) and METABRIC cohort (P = 0.037, HR: 0.9, 95% CI: 0.81–0.99).Conclusions: The IES has a predictive value for response to neoadjuvant trastuzumab therapy and independent prognostic value for HER2-positive breast cancer.
A Three-Gene Prognostic Signature Based on Circular RNA-Associated Competing Endogenous RNA Network for Patients with Lung Adenocarcinoma
Authors: Wang Xuelong , Zhou Bin , Xia Yuxin , Zuo Jianxin , Liu Yanchao , Bi Xin , Luo Xiong , Zhang Chengwei 
Published: October 2020

Abstract
Background: Evidence is increasingly indicating that circular RNAs (circRNAs) are closely involved in tumorigenesis and cancer progression. However, functions of circRNAs in lung adenocarcinoma (LUAD) are still unknown. It is necessary to investigate the regulatory mechanism of circRNAs based on competing endogenous RNA (ceRNA) network in LUAD procession and further construct a prognostic signature for predicting overall survival of LUAD patients.Methods: Differentially expressed circRNAs (DEcircRNAs), differentially expressed miRNAs (DEmiRNAs) and differentially expressed mRNAs (DEmRNAs) were selected to construct the ceRNA network based on TargetScan prediction tool and Pearson correlation coefficient. Functional and pathway enrichment analysis were performed using DAVID database. A PPI network was constructed and then visualized by Cytoscape software. Finally, we constructed a prognostic signature for LUAD patients using LASSO method and assessed the prognostic performance in the validation cohort.Results: A total of 38 DEcircRNAs, 56 DEmiRNAs, and 960 DEmRNAs were identifed. Based on the interactions predicted by TargetScan, we constructed a circRNA-associated ceRNA network including 11 DEcircRNAs, 8 DEmiRNAs and 49 DEmRNAs. GO and KEGG pathway analysis indicated that the circRNA-associated ceRNA network might be involved in regulation of GTPase activity and endothelial cell differentiation. After removing the discrete points, a PPI network containing 12 DEmRNAs was constructed. Univariate cox regression analysis showed that three DEmRNAs were significantly associated with overall survival. Therefore, we constructed a three-gene prognostic signature for LUAD patients using LASSO method. By applying the signature, patients in the training cohort could be categorized into high-risk or low-risk subgroup with significant survival difference (HR: 1.62, 95% CI: 1.12-2.35, log-rank p = 0.009). The prognostic performance was confirmed in an independent GEO cohort (HR: 2.59, 95% CI: 1.32-5.10, log-rank p = 0.004). Multivariate cox regression analysis proved that the three-gene signature was an independent prognostic factor for LUAD.Conclusions: Our findings provided a deeper understanding of the circRNA-associated ceRNA regulatory mechanism in LUAD pathogenesis and constructed a prognostic signature that could be a useful guide for personalized treatment of LUAD patients.