bluuebunny/crossref_metadata_2025_split huggingface dataset:
Searching for obscured AGN in z ∼ 2 submillimetre galaxies
Authors: Chen H. , Garrett M. A. , Chi S. , Thomson A. P. , Barthel P. D. , Alexander D. M. , Muxlow T. W. B. , Beswick R. J. , Radcliffe J. F. , Wrigley N. H. , Guidetti D. , Bondi M. , Prandoni I. , Smail I. , McHardy I. , Argo M. K. 
Published: April 2020

Aims. Submillimetre-selected galaxies (SMGs) at high redshift (z ∼ 2) are potential host galaxies of active galactic nuclei (AGN). If the local Universe is a good guide, ∼50% of the obscured AGN amongst the SMG population could be missed even in the deepest X-ray surveys. Radio observations are insensitive to obscuration; therefore, very long baseline interferometry (VLBI) can be used as a tool to identify AGN in obscured systems. A well-established upper limit to the brightness temperature of 105 K exists in star-forming systems, thus VLBI observations can distinguish AGN from star-forming systems via brightness temperature measurements.
Methods. We present 1.6 GHz European VLBI Network (EVN) observations of four SMGs (with measured redshifts) to search for evidence of compact radio components associated with AGN cores. For two of the sources, e-MERLIN images are also presented.
Results. Out of the four SMGs observed, we detect one source, J123555.14, that has an integrated EVN flux density of 201 ± 15.2 μJy, corresponding to a brightness temperature of 5.2 ± 0.7 × 105 K. We therefore identify that the radio emission from J123555.14 is associated with an AGN. We do not detect compact radio emission from a possible AGN in the remaining sources (J123600.10, J131225.73, and J163650.43). In the case of J131225.73, this is particularly surprising, and the data suggest that this may be an extended, jet-dominated AGN that is resolved by VLBI. Since the morphology of the faint radio source population is still largely unknown at these scales, it is possible that with a ∼10 mas resolution, VLBI misses (or resolves) many radio AGN extended on kiloparsec scales.
Living on the edge: Rossby wave instability and HFQPOs in black hole binaries
Authors: Varniere P. , Vincent F. H. , Casse F. 
Published: April 2020

Context. The Rossby wave instability (RWI) has been proposed to explain the origin of the high-frequency quasi-periodic oscillations observed in the X-ray emission of astrophysical systems harbouring black holes. Recent numerical computations have proven that the RWI does exist in a general relativistic context and that its presence is associated with a time-variable X-ray emission from the disc.
Aims. Using our new Numerical Observatory of Violent Accreting system, NOVAs, we explore the way the RWI impacts an accretion disc orbiting a spinning black hole under realistic astrophysical conditions. Our aim is to study the impact of the presence of the RWI in the very inner part of the accretion disc on known observables and explore some possibly new ones.
Methods. We present the first full general relativistic hydrodynamical simulations of the RWI occurring at the last stable orbit of an accretion disc orbiting around a Kerr black-hole. Those simulations, coupled with a full general relativistic ray-tracing, have allowed us to directly compare our simulations with the observables we obtained from the X-ray emission of the disc.
Results. Our study shows, for the first time, that the RWI naturally arises near the inner edge of an accretion disc whenever it gets close to its last stable orbit, as predicted analytically. From there, we show that not only does the RWI create a visible timing feature but it also impacts the energy spectrum of the source, which exhibits a high energy extension due to the presence of hot vortices generated by the RWI in the disc. Our study also shows that systems with the RWI present at the inner edge of the disc only exhibit similar behavior to systems in which HFQPOs have been detected.
Second Opinions before Surgery Have the Potential to Reduce Costs – An Exploratory Analysis
Authors: Weyerstraß Jan , Prediger Barbara , Neugebauer Edmund , Pieper Dawid 
Published: April 2020

Abstract
Aim In this study cost data of patientʼs first and second opinion of a German second opinion program of patients with orthopedic indications are raised and compared.
Methods Anonymized patient data were used from a second opinion program gathered in the period from 2013 to 2015. Costs of the first and second opinion were raised using DRG, the EBM catalog, the remuneration agreement on physical therapy and the price of drugs. In order to increase transferability, initial therapy recommendation and second opinion were compared in a cost analysis to determine a theoretical savings potential.
Results A total of 170 consecutive patients with orthopedic indication and first and second opinion were analyzed in this study. Only one out of three initial therapy recommendations was confirmed by the second opinion. In the second opinion, physiotherapy and pain therapy were often suggested for indications which received a surgery referral by the initial therapy recommendation. In scenario 1 (average resource use), the costs of the first therapy recommendation in median was 5020.96 € (IQR = 961.71 – 7342.66), the second opinion was 322.07 € (IQR = 146.39 – 1341.32). In median, the operation costs of the initial therapy recommendation were equal to 156.12 physiotherapeutic sessions and 26.02 N3 packs Ibuprofen 800.
Conclusion Therapy costs for the initial therapy recommendation are clearly exceeding the therapy costs of the second opinion. This assumes a potential to reduce therapy costs with the use of a second opinion. This study lays the foundation to carry out further conclusive analyses concerning this matter.
Clinical and Cytogenomic Characterization of De Novo 11p14.3-p15.5 Duplication Associated with 18q23 Deletion in an Egyptian Female Infant
Authors: Afifi Hanan H. , El-Kamah Ghada Y. , Kamel Alaa K. , Abd Allah Sally G. , Hammad Sayda , Sayed-Ahmed Mohammed M. , Hussein Shymaa H. , Mohamed Amal M. 
Published: April 2020

AbstractPaternal microduplication of 11p14.3-p15.5 causes the clinical manifestations of Beckwith–Wiedemann syndrome (BWS), while microdeletion of 18q23-ter is clinically characterized by short stature, congenital malformations, and developmental delay. We describe a 15-month-old girl presenting with protruding tongue, dysmorphic facial features, moderate developmental delay, umbilical hernia, hypotonia, mild-to-moderate pulmonary hypertension, small patent ductus arteriosus, and mild ventricular septal hypertrophy. Brain magnetic resonance imaging showed mild atrophic changes. Chromosomal analysis revealed 46, XX, add(18)(q23). Fluorescence in situ hybridization using subtelomere 18q and whole chromosome painting 18 showed subtelomere deletion in 18q, and the add segment was not derived from chromosome 18. Microarray-based comparative genomic hybridization detected a 22 Mb duplication of chromosome 11p15.5p14.3 and a 3.7 Mb deletion of chromosome 18q23. The phenotype of the chromosomal rearrangements is probably resulted from a combination of dosage-sensitive genes. Our patient had clinical manifestations of both 18q deletion and BWS.
A Study on Knowledge and Practice on Maternal Bed sharing Among Mothers in A Selected Hospital at Mangalore
Authors: Nongkynrih Rikynti , Cutinho Savitha Pramilda , D'almeida Victoria 
Published: April 2020

AbstractA non-experimental descriptive correlative research design was used to assess the knowledge and practice of 100 mothers whose babies are within 0-3 ½ months of age regarding maternal bed sharing. The sample was recruited by purposive sampling technique. A structured knowledge questionnaire and a self report practice checklist were used to collect the data. The finding in the current study reveals that 50% of the mothers had an average knowledge and 46% had poor knowledge whereas 4% had very good knowledge on maternal bed sharing and the mean on safe practice (14.42) is more than that of unsafe practice (12.52) which shows that the mothers were following safe practices. There was no significant association of knowledge and practice of mothers with selected demographic variables; however there is an association on practice of maternal bed sharing with educational status and number of children. The results showed that although the mothers had an average knowledge regarding maternal bed sharing but their practices were safe. Mothers with good knowledge can bring down the Sudden Infant death rate.
Prevalence of voice disorders in the Department of Speech- Language Pathology of a tertiary care hospital of Mangaluru: A retrospective study of 11 years
Authors: Dodderi Thejaswi , Philip Nikita Elsa , Mutum Kalpana 
Published: April 2020

Abstract
Background: Voice disorder is now considered a 'public health concern'. Epidemiological studies of yesteryears performed in the West disseminate the importance of prevention and early identification of the change in voice. In India 'Vocology' or study of voice production is slowly emerging with specific attention to vocal health and voice care. Aim of the study: The present study implemented a retrospective observational design to identify prevalence of voice disorders in a tertiary care hospital.
Method: The Diagnostic register of Department of Audiology and Speech-Language Pathology of a semi-urban hospital was accessed from January 1st 2007 till January 31st 2018. Patients diagnosed with a voice disorder, in-isolation and/or in conjunction to a medical condition, were tabulated. The data was tallied under the following categories: type of voice disorder; nature of voice disorder; age of onset; gender and perceptual features.
Results: Results of the study suggested 21.4% prevalence of voice disorder. In addition the study also noted maximum prevalence of vocal nodule; adult male subjects exhibited a higher rate of vocal fold pathology and increased prevalence of perceptually hoarse voice.
Conclusion: The data from the study accounts voice problems to be on higher side with vocal fold hyper-function disorder topping the chart.
A Study on Contributing Factors of Nurses Migration to Overseas among the Staff Nurses Working In Selected Hospital at Mangalore
Authors: Philip Harit , P. Bindhu P , Babu Aswathi , Cutinha Elveera , Joseph Jeena , Vas Jasmine Sarita 
Published: April 2020

AbstractNurses are the backbone of the health care sector. They have a vital role in the patient care as well as in the maintenance of standards in their profession. A significant shortage exists in India where nurses are migrating to other countries due to various reasons. This is important globally because countries with the lowest nursing and health care workforce capacities have the poorest health outcomes. Objective: To find the contributing factors for nurses migration to overseas among the staff nurses' Materials and Methods: A descriptive approach was adopted for this study. The study was conducted in Father Muller Medical College Hospital at Mangaluru. The study sample was 103 staff nurses'. A baseline proforma and a checklist were used to collect the data to assess the contributing factors of nurses' migration to overseas. The subjects were selected by using convenient random sampling technique. Results: The data in the present study revealed that, staff nurses 71.84% were between the age group of 21-25 years. Most (88.35%) of the subjects were females. Majorities (82.53%) of the subjects were single. 90.30% of the subjects belong to Christian religion and rest of them belongs to Hindu religion. Proportionately (67.97%) of the subjects who participated were had the qualification of B.Sc (N). Quiet a more number of staff Nurses' (78.64%) was having the work experience between 1- 3 years. The data from the checklist of contributing factors revealed that the majority (95.14%) of them said that less salary in India is the major contributing factor for migration. The second reason given by the subjects was better employment opportunity (92.23%). The third most reason indicated by the subject was the opportunity to improve the professional skill and practice in abroad (92.21%). The marriage as a contributing factor to migrate was least by only (25.24%). The next least was additional payment for extra hours (45.63%). Interpretation and conclusion: After conducting the study the result showed that, The main contributing factors of nurses migration are less salary in India (95.14%), Better employment opportunities in abroad (92.23%) and the opportunity to improve the professional skill and practice in abroad (92.21%). Also we found that there is no specific contributing factor rather they had variety of contributing factors which influences the nurses for migration.
A Correlational Study to Assess The Job Adjustment and Service Attitude of Male Nurses Working in Private Hospitals of Udupi and Mangalore Districts, Karnataka.
Authors: N. Geo Sebastia , George Mariamma V ,   Shalini
Published: April 2020

Abstract
Purpose of the study : The purpose of the study was to examine the effect of job adjustment on service attitude of male nurses.
Background of the problem : The shortage and turnover of nurses is a critical problem worldwide. Many people view nursing as a woman's profession; men have three major gender barriers in the nursing education process such as social isolation, refusal to address individual learning needs and the lack of acknowledgement of men in nursing profession.
Methods : A correlational design was adopted. Data were collected from a total of 146 male nurses from Udupi and Mangalore districts, Karnataka in 2013.
Findings : Majority of the male nurses 90(60.80%) were between the age group of 20-25years. Out of the 146 subjects 67(43.30%) of them were with the educational qualification of BSc Nursing, 64(42.20%) of them were with GNM qualification, and 15(10.10%) were with PB BSc Nursing. Most 60(40%) of them were with clinical experience of 6 months to one year. Majority 72(48.6%) of them were working in intensive care unit. There was a strong, positive, statistically significant relationship between job adjustment and service attitude(r=0.563, p<0.00), inferring that service attitude is dependent on job adjustment.
Conclusion : : The findings show that there was significant relationship between job adjustment and service attitude among male nurses.
Whole Exome Sequencing Provides the Correct Diagnosis in a Case of Osteopathia Striata with Cranial Sclerosis: Case Report of a Novel Frameshift Mutation in AMER1
Authors: García-Aznar José María , Ramírez Noelia , De Uña David , Santiago Elisa , Monserrat Lorenzo 
Published: April 2020

AbstractThe diagnosis of rare diseases with multisystem manifestations can constitute a difficult process that delays the determination of the underlying cause. Whole exome sequencing (WES) provides a suitable option to examine multiple target genes associated with several disorders that display common features. In this study, we report the case of a female patient suspected of having Sotos syndrome. Screening for the initially selected genes, considering Sotos syndrome and Sotos-like disorders, did not identify any pathogenic variants that could explain the phenotype. The extended analysis, which considered all genes in the exome associated with features consistent with those shown by the studied patient, revealed a novel frameshift variant in the AMER1 gene, responsible for osteopathia striata with cranial sclerosis. WES analysis and an updated revision of previously reported disease-causing mutations, proved useful to reach an accurate diagnosis and guide further examination to identify critical abnormalities.
Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism
Authors: Yu Di , Liu Yang , Zhou Yiqiang , Ruiz-Rodado Victor , Larion Mioara , Xu Guowang , Yang Chunzhang 
Published: April 2020

Significance
IDH1 mutation is a common genetic abnormality in human malignancies, whereas selective therapeutics for IDH1-mutated malignancies remain unavailable. Our present study reveals that IDH1-mutated cancer cells exhibit addiction to Nrf2-governed antioxidative pathways. Blockade of Nrf2 transcriptional activity achieved synergistic lethality with a neomorphic IDH1 mutation. We also showed that triptolide serves as a potent Nrf2 inhibitor, which inhibited Nrf2 transcriptional activity and led to apoptotic changes in IDH1-mutated cells via redox catastrophe. We believe that our findings highlight the broad scope and significance of Nrf2 blockade as a therapeutic strategy and provide an actionable strategy for IDH1-mutated malignancies.
Exosomes derived from neural progenitor cells preserve photoreceptors during retinal degeneration by inactivating microglia
Authors: Bian Baishijiao , Zhao Congjian , He Xiangyu , Gong Yu , Ren Chunge , Ge Lingling , Zeng Yuxiao , Li Qiyou , Chen Min , Weng Chuanhuang , He Juncai , Fang Yajie , Xu Haiwei , Yin Zheng Qin 
Published: April 2020

ABSTRACTRetinal degeneration (RD) is one of the most common causes of visual impairment and blindness and is characterized by progressive degeneration of photoreceptors. Transplantation of neural stem/progenitor cells (NPCs) is a promising treatment for RD, although the mechanisms underlying the efficacy remain unclear. Accumulated evidence supports the notion that paracrine effects of transplanted stem cells is likely the major approach to rescuing early degeneration, rather than cell replacement. NPC‐derived exosomes (NPC‐exos), a type of extracellular vesicles (EVs) released from NPCs, are thought to carry functional molecules to recipient cells and play therapeutic roles. In present study, we found that grafted human NPCs (hNPCs) secreted EVs and exosomes in the subretinal space (SRS) of RCS rats, an RD model. And direct administration of mouse neural progenitor cell‐derived exosomes (mNPC‐exos) delayed photoreceptor degeneration, preserved visual function, prevented thinning of the outer nuclear layer (ONL), and decreased apoptosis of photoreceptors in RCS rats. Mechanistically, mNPC‐exos were specifically internalized by retinal microglia and suppressed their activation in vitro and in vivo. RNA sequencing and miRNA profiling revealed a set of 17 miRNAs contained in mNPC‐exos that markedly inhibited inflammatory signal pathways by targeting TNF‐α, IL‐1β, and COX‐2 in activated microglia. The exosomes derived from hNPC (hNPC‐exos) contained similar miRNAs to mNPC‐exos that inhibited microglial activation. We demonstrated that NPC‐exos markedly suppressed microglial activation to protect photoreceptors from apoptosis, suggesting that NPC‐exos and their contents may be the mechanism of stem cell therapy for treating RD.
First data from the CUPID-Mo neutrinoless double beta decay experiment
Authors: Schmidt B. 
Published: April 2020

Abstract
The CUPID-Mo experiment is searching for neutrinoless double beta decay in 100Mo, evaluating the technology of cryogenic scintillating Li2
100MoO4 detectors for CUPID (CUORE Upgrade with Particle ID). CUPID-Mo detectors feature background suppression using a dual-readout scheme with Li2MoO4 crystals complemented by Ge bolometers for light detection. The detection of both heat and scintillation light signals allows the efficient discrimination of α from γ&β events. In this proceedings, we discuss results from the first 2 months of data taking in spring 2019. In addition to an excellent bolometric performance of 6.7 keV (FWHM) at 2615 keV and an β separation of better than 99.9% for all detectors, we report on bulk radiopurity for Th and U. Finally, we interpret the accumulated physics data in terms of a limit of

T

1
/
2

0
v

> 3 × 1023 yr for 100Mo and discuss the sensitivity of CUPID-Mo until the expected end of physics data taking in early 2020.
Air pollution lowers high skill public sector worker productivity in China
Authors: Kahn Matthew E , Li Pei 
Published: April 2020

Abstract
China’s urbanites continue to be exposed to high levels of air pollution. Such pollution exposure raises mortality risk, lowers the day-to-day sentiment of the population and lowers outdoor worker productivity. Using a unique set of data for Chinese judges, we document that local air pollution also lowers the productivity of high skilled government officials who work indoors. Our new evidence on the effects of air pollution highlights both the challenge that pollution poses for quality of life and workforce productivity and indicates that the Chinese urban elites gain co-benefits when their cities burn less fossil fuel.
Cyclic voltammetry, photocatalytic and antimicrobial comparative studies of fabrication Fe3O4 and Fe3O4/PAN nanofibers
Authors: Mogomotsi Ranku N , Akinola Stephen S , Emeka Elemike E , Fayemi Omolola E 
Published: April 2020

Abstract
This study reports the properties of green mediated synthesized iron oxides nanoparticles (Fe3O4 NPs) from peel extracts of pomegranate plant and its polyacrylonitrile/iron oxide composite nanofibers (Fe3O4/PAN). The following were used to characterize the synthesized nanoparticles and its polymer nanofibers; FT-IR, UV-Visible spectroscopy, scanning electron microscope SEM, TEM and cyclic voltammetry. The antimicrobial activities of synthesized nanoparticles were investigated against selected bacterial pathogens. For the plant extract, FTIR revealed OH characteristics peaks at 3271 cm−1 and 1600 cm−1 while the absorption peaks at 577 and 430 cm1 showed successful reduction of the precursor to Fe3O4 nanoparticles. The SEM images showed a spherical morphology of Fe3O4 and that of the composite with entrapped Fe3O4 into the PAN nanofibers. Photocatalytic process showed that the synthesized Fe3O4 nanoparticles has degradation efficiency of 71.36% and the nanofibers exhibited efficiency of 22.68% towards methylene blue (MB) dye. However, further kinetic analysis of the degradation process put Fe3O4/PAN nanofibers (NF) at a better correlation coefficient of 0.9239 than the Fe3O4 nanoparticles. Electrochemical studies using cyclic voltammetry showed that PAN functionalized with Fe3O4 is more electroactive as compared to the other electrodes studied. The anodic peak potential at 599 mV also confirmed the presence of Fe3O4 in the nanocomposite Fe3O4/PAN. The antimicrobial studies revealed that as the concentration of the green mediated Fe3O4 nanoparticle increases in the composite Fe3O4/PAN an excellent antimicrobial activity against selected pathogens were observed, showing Fe3O4 nanoparticles potentials to control pathogens of public health significance.
OpenBioLink: a benchmarking framework for large-scale biomedical link prediction
Authors: Breit Anna , Ott Simon , Agibetov Asan , Samwald Matthias 
Published: April 2020

Abstract

Summary
Recently, novel machine-learning algorithms have shown potential for predicting undiscovered links in biomedical knowledge networks. However, dedicated benchmarks for measuring algorithmic progress have not yet emerged. With OpenBioLink, we introduce a large-scale, high-quality and highly challenging biomedical link prediction benchmark to transparently and reproducibly evaluate such algorithms. Furthermore, we present preliminary baseline evaluation results.

Availability and implementation
Source code and data are openly available at https://github.com/OpenBioLink/OpenBioLink.

Supplementary information
Supplementary data are available at Bioinformatics online.