bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Red Queen’s Crown: an evolutionary arms race between coronaviruses and mammalian species reflected in positive selection of the ACE2 receptor among many species
Authors: Hajibabaei Mehrdad , Singer Gregory A. C. 
Published: May 2020

AbstractThe world is going through a global viral pandemic with devastating effects on human life and socioeconomic activities. This pandemic is the result of a zoonotic coronavirus, Severe Acute Respirsatory Syndrom Coronavirus 2 (SARS-CoV-2) which is believed to have originated in bats and transferred to humans possibly through an intermediate host species (Zhou et al. 2020; Coronaviridae Study Group of the International Committee on Taxonomy of Viruses 2020). The virus attacks host cells by attaching to a cell membrane surface protein receptor called ACE2 (Ge et al. 2013; Zhou et al. 2020). Given the critical role of ACE2 as a binding receptor for a number of coronaviruses, we studied the molecular evolution of ACE2 in a diverse range of mammalian species. Using ACE2 as the target protein, we wanted to specifically test the Red Queen hypothesis (Dawkins and Krebs 1979) where the parasite and host engage in an evolutionary arms race which can result in positive selection of their traits associated to their fitness and survival. Our results clearly show a phylogenetically broad evolutionary response, in the form of positive selection detected at the codon-level in ACE2. We see positive selection occurring at deep branches as well as 13 incidents at the species level. We found the strongest level of positive selection in Tasmanian devil (Sarcophilus harrisii), donkey (Equus asinus), large flying fox (Pteropus vampyrus), Weddell seal (Leptonychotes weddellii), and dog (Canis lupus familiaris). At the codon-level, we found up to 10% of ACE2 codons are impacted by positive selection in the mammalian lineages studied. This phylogenetically broad evolutionary arms race can contribute to the emergence of new strains of coronaviruses in different mammalian lineages with a potential to transfer between species given the common binding receptor ACE2. Our study provides a molecular evolutionary perspective to the current pandemic and sheds light on its evolutionary mechanisms.“Nothing in biology makes sense except in the light of evolution” (Theodosius Dobzhansky)
Construction output modelling: a systematic review
Authors: Oshodi Olalekan , Edwards David J. , lam Ka Chi , Olanipekun Ayokunle Olubunmi , Aigbavboa Clinton Ohis 
Published: May 2020

PurposeConstruction economics scholars have emphasised the importance of construction output forecasting and have called for increased investment in infrastructure projects due to the positive relationship between construction output and economic growth. However, construction output tends to fluctuate over time. Excessive changes in the volume of construction output have a negative impact upon the construction sector, such as liquidation of construction companies and job losses. Information gleaned from extant literature suggests that fluctuation in construction output is a global problem. Evidence indicates that modelling of construction output provides information for understanding the factors responsible for these changes.MethodologyAn interpretivist epistemological lens is adopted to conduct a systematic review of published studies on modelling of construction output. A thematic analysis is then presented, and the trends and gaps in current knowledge are highlighted.FindingsIt is observed that interest rate is the most common determinant of construction output. Also revealed is that very little is known about the underlying factors stimulating growth in the volume of investment in maintenance construction works. Further work is required to investigate the efficacy of using non-linear techniques for construction output modelling.OriginalityThis study provides a contemporary mapping of existing knowledge relating to construction output and provides insights into gaps in current understanding that can be explored by future researchers.
Airport project delivery within BIM-centric construction technology ecosystems
Authors: Keskin Basak , Salman Baris , Ozorhon Beliz 
Published: May 2020

PurposeThe purpose of this paper is to systematically analyse how building information modelling (BIM) transforms complex infrastructure settings (i.e. airports) around digital technologies by enhancing connectivity and collaboration between major stakeholders and construction technology solutions. The objectives include understanding each project party's perspective for BIM implementation to align their motivations and connectivity along project's supply chain network and how BIM drives construction technology ecosystem uses for a more integrative and collaborative project delivery.Design/methodology/approachThe study adopts qualitative data collection and analysis methods comprising semi-structured interviews, thematic analysis and an explanatory case study of a large-hub airport project.FindingsThe study findings show that enabling BIM implementation leads to streamlining construction technology ecosystem uses that increase connectivity within project parties' processes. Airports – as hosting high-value assets – can fast realize value of synergistic activities throughout project delivery by harnessing significant amount of siloed data created by each major party.Originality/valueThe study provides a structured analysis of how complex project settings leverage construction technology uses through their core BIM processes by highlighting multi-party approaches from an ecosystem perspective. This study also contributes to the body of knowledge and practice by presenting a transferrable and scalable approach for leveraging connected construction technology in a large-scale project involving fragmented processes managed by a large number of stakeholders.
Gender, diversity management perceptions, workplace happiness and organisational citizenship behaviour
Authors: Mousa Mohamed , Massoud Hiba K. , Ayoubi Rami M. 
Published: May 2020

PurposeThe purpose of this paper is to investigate whether females have different perceptions of diversity management and workplace happiness compared to their male colleagues. Furthermore, the paper explores whether diversity management perceptions mediate the relationship between workplace happiness and organisational citizenship behaviour.Design/methodology/approachA total of 260 questionnaires from a number of public hospitals in Egypt were analysed using both t-test and Structural Equation Modelling.FindingsWe found that female physicians perceive diversity management policies/protocols more positively than their male colleagues. Moreover, gender has no or little effect on physicians’ perceptions of workplace happiness. We also found that workplace happiness positively affects physicians’ organisational citizenship behaviour, and finally, diversity management practices can mediate the relationship between workplace happiness and physicians’ organisational citizenship behaviour.Practical implicationsWe believe that managers can raise the feeling of workplace happiness among their staff if they maintain some personal relationships with physicians, care about the physicians’ work/life balance, promote after work gatherings, initiate coffee time talks, encourage open communication practices and more.Originality/valueThe paper is based on the argument that although employees might be happy in the workplace through (engagement, job satisfaction, affective commitment), their happiness, however,will unlikely be reflected into a positive organisational citizenship behaviour towards their organisation, except (social exchange theory) they feel or perceive (equity theory) the overall practices of diversity management in that organisation positively. Thus, studying the mediating effect of perceptions towards diversity management is mainly our contribution.
The student as customer and quality in higher education
Authors: Calma Angelito , Dickson-Deane Camille 
Published: May 2020

PurposeThis paper explores some management concepts and how applying these concepts from business to higher education can be problematic, let alone incompatible, particularly in relation to measuring quality in higher education.Design/methodology/approachIt provides a conceptual understanding of the literature on quality in the higher education context. It does so by examining the literature on students as customers, customer expectations, customer satisfaction and other management theories that have been applied to higher education.FindingsIt argues that the current bases for perceiving quality such as meeting customer expectations, satisfying the customer, ensuring quality control, meeting standards and assessing the cost associated with poor quality are in disagreement with the principal aims and measures of quality in higher education.Research limitations/implicationsThis paper can certainly benefit from many other concepts in business that have been applied in higher education, which it lacks. It only focussed on a number of key and popular ideas in management theory that have been used in higher education more broadly.Practical implicationsStudent-focussed quality initiatives can be devoid of the student as customer concept. How programs, subjects and experiences are curated can be solely for the purpose of continuous improvement. Second, universities that choose to treat the student as a customer may find it beneficial to apply a relationship marketing approach to higher education. Lastly, those against the student as customer concept may focus on the long-term impact of quality initiatives such as promoting lifelong learning, building long-term relationships with alumni and employers and those that further promote academic integrity.Originality/valueSome considerations have been offered. These considerations revisit the basic notions of teaching and learning in higher education. It puts an emphasis on sidestepping the student as customer metaphor, that learning is not expressed in dollar terms, and that the quality of the student experience cannot be measured by student evaluation alone because it is felt much later in life.
Relationships between young adults’ housing tenure, elements of perceived job security and social capital in Britain
Authors: Aguda Oluwadamilola , Ebohon Obas John 
Published: May 2020

Purpose
Against the backdrop of the changing trends in tenure in the UK housing system, young adults are faced with different situations that continue to shape their housing consumption and decisions. The purpose of this paper is to investigate the relationships amongst young adults’ housing tenure, social capital and elements of perceived job security in Britain. Socio-psychological dimension of housing tenure decisions has been receiving attention by housing market analysts and practitioners seeking deeper understandings of the UK housing market dynamics, particularly in the wake of changing tastes and preferences of young people concerning housing decisions across major cities of the world.

Design/methodology/approach
A quantitative approach has been applied to the harmonised version of the British Household Panel Survey (BHPS) from 2001 to 2015.

Findings
The authors discovered that British young adults’ homeownership decisions are increasingly influenced by social capital and elements of perceived job insecurity, depending on their tenure of origin. Furthermore, this study will significantly enhance the understanding of tenure shifts amongst young adults in the UK and provide property developers, local authorities and central governments the knowledge and information to guide economic policies, urban renewal towards achieving better social cohesion and sustainable communities.

Originality/value
Very little has been done to investigate the contributions of social capital formation, for example, neighbourhood or social integration and social relations and elements of perceived job security on housing tenure transitions among British young adults. This study will further provide property developers, local authorities and central governments the knowledge and information to guide economic policies, urban renewal towards achieving better social cohesion and sustainable communities.
Determinants of international marketing strategy for emerging market multinationals
Authors: Rana Sudhir , Prashar Sanjeev , Barai Munim Kumar , Hamid Abu Bakar Abdul 
Published: May 2020

PurposeThe main objective of this study is to evolve the basis of beneficial impact assessment of international marketing strategy (IMS) for emerging market multinationals by applying construct-measurement research methodology. The purpose of this study is to link the conceptual definition and empirical indicators of the proposed integrated model with the objective on “Developing Model to Assess Benefit Impacts Generated by International Marketing”, the authors named it GAMBIT.Design/methodology/approachSelf-administered questionnaires were used to collect data from international marketing executives and senior management executives from Indian manufacturing firms using Churchill's approach (1979, 1987). Exploratory and confirmatory factor analyses and structural equation modeling (using SPSS Statistics 20.0 and AMOS) were used to develop the GAMBIT model. Various hypotheses pertaining to perfect order fulfillment and quality level were formulated.FindingsIn the order of significance, the four key influential factors for beneficial impact assessment in the multicultural global environment are as follows: sources of beneficial impacts; operational efficiency; international marketing strategic choice and beneficial outcomes.Originality/valueAlthough companies have realized the importance of assessing beneficial impacts, they often do not know how exactly the assessment should be made. Thus, the present study provides a useful tool for evaluating the totality of beneficial impacts offered by IMS.
Identification of barriers to synergistic implementation of TQM-SCM
Authors: Kaur Mandeep , Singh Kanwarpreet , Singh Doordarshi 
Published: May 2020

PurposeThe study aims at finding out major barriers for synergistic adoption of TQM-SCM in the medium- and large-scale manufacturing organizations in India. All these barriers create hurdles for the organizations as well as supply chain partners in improving their business performance. The study is a blend of theoretical and practical frameworks, which will focus on key barriers leading to interrupt the successful synergistic implementation of TQM-SCM in manufacturing organization.Design/methodology/approachFirstly, survey of 116 Indian organizations has been carried out to identify barriers that hinder successful implementation of TQM-SCM. Afterward, VIKOR approach was proposed to rank the major barriers of TQM-SCM implementation in Indian manufacturing organizations.FindingsIdentification of barriers to synergistic implementation of TQM-SCM in the manufacturing industry of India, ranking of these barriers in terms of their severity.Originality/valueThe adoption of TQM-SCM on synergistic basis is still in its early stages in India. To the authors’ knowledge, this is the first study that is designed to prioritize barriers responsible for hindering successful synergistic implementation of (TQM-SCM) in Indian manufacturing industry. Further, the results of the study will be helpful for managers in order to prepare action plans to overcome the hurdles to TQM-SCM implementation.
The influence of YouTubers on followers’ use intention
Authors: Corrêa Stela Cristina Hott , Soares João Luiz , Christino Juliana Maria Magalhães , Gosling Marlusa de Sevilha , Gonçalves Carlos Alberto 
Published: May 2020

Purpose
This study aims to investigate the relationship between the follower’s engagement with YouTubers and his/her intention of using a brand they advertise or use. Self-connection, brand love and trust are mediating variables concerning the YouTuber–follower relationship and involvement is the antecedent variable of the engagement.

Design/methodology/approach
A survey was carried out and 272 YouTubers’ followers responded. The structural model was tested by covariance-based structural equation modeling using the software R, v3.6.0.

Findings
The present study reveals that the follower’s engagement with YouTubers presents itself within cognitive, affective and behavioural aspects; it rises from the involvement the followers have with their favourite YouTuber. Engagement, enhanced by self-connection, love and trust in the YouTuber, impacts the intention of use of a brand he/she indicates or uses.

Practical implications
YouTube is a relevant channel for advertising and promoting a brand. Hence, the company should bear in mind the fact that the YouTuber appointed to represent its image must be connected to the feelings and interests of their followers as well as those of the brands to be publicised.

Originality/value
The present research proposes a novel conceptual connection to engagement, established no longer by the brand of a product or service, but by YouTubers. It aims at rendering contribution to this subject as it investigates the correlation of use intention of a brand, subject to the engagement with a human brand, herein represented by YouTubers.
Experiencing family ethnography: challenges, practicalities and reflections on practice
Authors: Nash Cathriona , O'Malley Lisa , Patterson Maurice 
Published: May 2020

Purpose
The purpose of this paper is to offer a critical reflection on the experience and challenges associated with conducting a family ethnography along with methodological guidance that generates insights for future researchers.

Design/methodology/approach
This paper uses a family ethnography as a methodological approach to investigate family consumption in context with a view towards capturing detailed consumption experiences.

Findings
A family ethnography is a valuable but challenging methodology to follow in its preparation, practice and publishing. Despite these challenges, they are surmountable with some lateral thinking to conduct methodologically and ethically sound ethnographic research.

Research limitations/implications
The method, challenges and guidance offered here can be used to make the most of ethnography as a methodological approach to family research.

Practical implications
The critical reflection of the experience and challenges of conducting a family ethnography along with the practical advice offered here may guide those considering using ethnographic research.

Originality/value
Contributions include a critical reflection on the experience and challenges of conducting a family ethnography, ethical and methodological guidelines to overcome them and operational guidelines for their use.
Biocompatible implant mimicking cartilage: A new horizon for reconstructive facial field
Authors: Biswas Biswajit Kumar , Dey Sutapa , Chakrabarty Anindya , Laha Arghya , Mandal Tapan Kumar , Karmakar Laxmikanta , Das Debajyoti 
Published: May 2020

AbstractCartilage is avascular with limited to no regenerative capacity, so its loss could be a challenge for reconstructive surgery. Current treatment options for damaged cartilage are also limited. In this aspect there is a tremendous need to develop an ideal cartilage‐mimicking biomaterial that could repair maxillofacial defects. Considering this fact in this study we have prepared twelve silicone‐based materials (using Silicone 40, 60, and 80) reinforced with hydroxyapatite, tri‐calcium phosphate, and titanium dioxide which itself has proven their efficacy in several studies and able to complement the shortcomings of using silicones. Among the mechanical properties (Young’s modulus, tensile strength, percent elongation, and hardness), hardness of Silicone‐40 showed similarities with goat ear (P > .05). Silicone peaks have been detected in FTIR. Both AFM morphology and SEM images of the samples confirmed more roughed surfaces. All the materials were nonhemolytic in hemocompatibility tests, but among the twelve materials S2, S3, S5, and S6 showed the least hemolysis. For all tested bacterial strains, adherence was lower on each material than that grown on the plain industrial silicone material which was used as a positive control. S2, S3, S5, and S6 samples were selected as the best based on mechanical characterizations, surface characterizations, in vitro hemocompatibility tests and bacterial adherence activity. So, outcomes of this present study would be promising when developing ideal cartilage‐mimicking biocomposites and their emerging applications to treat maxillofacial defects due to cartilage damage.
The simplified follicular lymphoma PRIMA‐prognostic index is useful in patients with first‐line chemo‐free rituximab‐based therapy
Authors: Kimby Eva , Lockmer Sandra , Holte Harald , Hagberg Hans , Wahlin Björn E. , Brown Peter , Østenstad Bjørn 
Published: May 2020

SummaryFollicular lymphoma (FL) is a heterogeneous disease; therefore, reliable prognostic tools are needed to plan treatment strategies. The FL International Prognostic Index (FLIPI) was developed before the rituximab era, while the PRIMA‐PI was built on rituximab chemotherapy. Our objective was to evaluate these two prognostic tools in a cohort of 291 patients with FL treated in two prospective randomised Nordic Lymphoma Group trials with rituximab ± interferon. All patients had symptomatic/progressive disease and were previously untreated. The PRIMA‐PI was prognostic for both time to treatment failure (TTF) and overall survival (OS) (log‐rank P = 0·003 and P < 0·001, respectively). The PRIMA‐PI high‐risk identified a small group of patients with a very short TTF and OS compared to the low‐risk group, with a hazard ratio (HR) of 1·90 (95% confidence interval [CI] 1·30–2·78, P = 0·001) and HR of 3·19 (95% CI 1·75–5·83, P < 0·001), respectively. The FLIPI risk groups were prognostic only for OS (log‐rank P = 0·018). The simplified PRIMA‐PI was valid in our FL cohort with first‐line rituximab‐containing chemo‐free therapy and shows an improved risk stratification compared to the FLIPI, especially in patients aged >60 years. Patients in the PRIMA‐PI high‐risk group should be considered for alternative therapies.
Prognostic utility of a geriatric nutritional risk index in combination with a comorbidity index in elderly patients with diffuse large B cell lymphoma
Authors: Lee Shin , Fujita Kei , Morishita Tetsuji , Negoro Eiju , Oiwa Kana , Tsukasaki Hikaru , Yamamura Osamu , Ueda Takanori , Yamauchi Takahiro 
Published: May 2020

AbstractReflecting the increasing risk in elderly patients with diffuse large B cell lymphoma (DLBCL), prognostic predictors other than the International Prognostic Index have attracted more attention. This study presents the first analysis of the prognostic utility of the Geriatric Nutritional Risk Index (GNRI) in combination with the Charlson Comorbidity Index (CCI) for overall survival (OS) in elderly DLBCL patients. A multicentre retrospective was conducted on a cohort of 451 patients (≥65 years). The GNRI and CCI were independent predictors in a multivariate Cox proportional hazard model. There was a nonlinear correlation between the GNRI and OS in a Cox model with restricted cubic spline. Multivariate receiver operating characteristic curves showed a significant improvement in prediction accuracy when the GNRI was added to CCI. Adding the GNRI to CCI yielded a significant category‐free net reclassification improvement (0·556; 95% CI: 0·378–0·736, P < 0·001) and integrated discrimination improvement (0·094; 95% CI: 0·067–0·122, P < 0·001). The decision curve analysis demonstrated the clinical net benefit associated with the adoption of the GNRI. The GNRI was not only a predictor of OS but also remarkably improved the prognosis prediction accuracy when incorporated with the CCI, having the ability to stratify the prognosis of elderly DLBCL patients.