bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of Anterior Uveitis in Patients with Axial Spondyloarthritis Treated with Anti-TNF or Anti-IL17A: A Systematic Review, A Pairwise and Network Meta-Analysis of Randomized Controlled Trials
Authors: Roche Damien , Badard Martin , Boyer Laurent , Lafforgue Pierre , Pham Thao 
Published: November 2020

Abstract
Background: Anterior uveitis (AU) is the most frequent extra-articular feature of axial spondyloarthritis (axSpA). We aimed to assess and compare the incidence of AU in axSpA patients treated with anti-TNF or anti-IL17A. Methods: We systematically reviewed PubMed, EMBase and Cochrane from inception to May 3, 2020, and searched for placebo-controlled and head-to-head randomized controlled trials (RCTs) assessing anti-TNF monoclonal antibodies (mAb) or soluble receptor fusion protein or anti-IL17A in patients with axSpA according to ASAS criteria and reporting safety data on AU. Data were extracted following a predefined protocol. We did pairwise and network meta-analyses for the primary outcome of AU flares (relapse or de novo) incidence and estimated summary odds ratios (ORs). We assessed the quality of evidence using the Cochrane risk-of-bias 2.0 tool. We ranked treatments according to their effectiveness in preventing AU flare using the P-score.Results: We identified 752 citations and included 33 RCTs, comprising 4544 treated patients (anti-TNF mAb: 2101, etanercept [ETN]: 699, anti-IL17A: 1744) and 2497 placebo-receiving patients. Incidence of uveitis was lower with anti-TNF mAb versus placebo (OR = 0.46; CI95% [0.24; 0.90]) and versus anti-IL17A (OR = 0.34; CI95% [0.12; 0.92]. According to the P-score, the ranking from the most to the least preventive treatment of uveitis flare was as follows: anti-TNF mAb, ETN, placebo, anti-IL17A. Conclusion: In RCTs assessing anti-TNF and anti-IL17A in axSpA, incident uveitis are rare events. However, this network meta-analysis demonstrates that anti-TNF mAb are associated with a lower incidence of uveitis compared to placebo and anti-IL17A.
Giant cells in temporal artery biopsies are associated with a reduced risk of large vessel involvement in patients with giant cell arteritis : a retrospective cohort study
Authors: Naderi Nazanin , Mohammad Aladdin , Wadström Karin , Willim Minna , Nilsson Jan-Åke , Turesson Carl 
Published: November 2020

Abstract
Background: Giant cell arteritis (GCA) is a systemic disease with extensive vascular involvement. There is limited and conflicting information on the relation between patient characteristics at diagnosis and future disease phenotypes. We aimed to investigate predictors of time dependent large vessel involvement (LVI) in a population-based cohort of patients with GCA. Methods: GCA patients with positive temporal artery biopsies (TAB) between 1997and 2010 were identified through a regional pathology register. A structured review of histopathology reports and relevant imaging studies was performed. Cases with LVI through July 2016 were identified. Patients were followed to first LVI, death, migration from the area or July 29, 2016. Event free survival by clinical and histopathologic features was estimated using the Kaplan-Meier method. Potential predictors of LVI were examined using Cox regression models.Results: A total of 274 patients were included. The mean age at GCA diagnosis was 75.7 years. Fifty-one patients (19 %) had documented LVI during the follow-up, corresponding to an incidence rate of 2.4/100 person-years. The median time from GCA diagnosis to the diagnosis of LVI was 4.5 years (interquartile range 0.6-7.4). Thirty-four patients had aortic involvement (67% of those with LVI; 12% of all GCA cases). Survival free of LVI was longer in patients with giant cells in the TAB (75th percentile 14.0 vs 6.7 years; p=0.014). In age-adjusted analysis, the presence of giant cells in the TAB was associated with reduced risk of LVI (hazard ratio 0.48; 95 % confidence interval 0.27-0.86). Conclusions: The negative association with giant cells in the TAB suggests that patients with LVI constitute a subset of GCA with particular disease mechanisms. This underlines the heterogeneity of GCA, which should be further explored in prospective studies.
Mitotic spindle organizing protein 2A (MZT2A) promotes NSCLC cell viability and invasion by upregulating galectin-3-binding protein (LGALS3BP), increases AKT phosphorylation via the MOZART2 domain and predicts poor NSCLC prognosis
Authors: Wang Huanxi , Jiang Xizi , Cheng Yu , Hu Yujiao , Zhang Yao , Su Hongbo , Zou Zifang , Wang Qiongzi , Ren Hongjiu , Liu Zongang , Zhang Jiameng , Qiu Xueshan 
Published: November 2020

Abstract
Background: Mitotic spindle organizing protein 2A (MZT2A) is localized at the centrosome and regulates microtubule nucleation activity in cells. This study assessed the role of MZT2A in non-small cell lung cancer (NSCLC). Methods: Differential MZT2A expression was bioinformatically assessed using the Cancer Genome Atlas database, Gene Expression Profiling Interactive Analysis database, and Kaplan-Meier survival data to determine the association between MZT2A expression and NSCLC prognosis. Furthermore, NSCLC tissue specimens from 132 patients were evaluated with immunohistochemistry. MZT2A was overexpressed or knocked down in NSCLC cells using cDNA and siRNA, respectively. The cells were subjected to various assays and treated with the selective Akt inhibitor LY294002 or co-transfected with galectin-3-binding protein (LGALS3BP) siRNA. Result: The levels of MZT2A mRNA and protein were upregulated in NSCLC lesions and MTZ2A expression was associated with larger tumor size, lymph node metastasis, and advanced TNM stages for NSCLC as well as poor NSCLC prognosis. MZT2A protein was also highly expressed in NSCLC cells compared to the expression in normal bronchial cells. MZT2A expression promoted NSCLC cell viability and invasion, whereas MTZ2A siRNA had the opposite effects on NSCLC cells in vitro. At the protein level, MZT2A induced Akt phosphorylation, promoting NSCLC proliferation and invasion (but the selective Akt inhibitor blocked these effects) through the upregulation of LGALS3BP via the MTZ2A MOZART2 domain, whereas LGALS3BP siRNA suppressed MTZ2A activity in NSCLC cells.Conclusions: MZT2A exhibits oncogenic activity by activating LGALS3BP and Akt in NSCLC. Future studies will assess MTZ2A as a biomarker to predict NSCLC prognosis or as a target to control NSCLC progression.
Deep Learning for Locally Advanced Nasopharyngeal Carcinoma Prognostication Based on Pre- and Post-treatment MRI
Authors: Li Song , Deng Yu-Qin , Hua Hong-Li , Li Sheng-Lan , Chen Xi-Xiang , Xie Bao-Jun , Zhu Zhiling , Liu Ruoyun , Huang Jin , Tao Ze-Zhang 
Published: November 2020

Abstract
Background: Although it has been reported by several studies that using AI to predict the prognosis of nasopharyngeal carcinoma (NPC) based on magnetic resonance (MR) image, the information around the tumor was not valued and the post-treatment MR images were ignored. Herein we aimed to predict the prognosis of advanced NPC (stage Ⅲ-Ⅳa) using pre- and post-treatment MR images based on deep learning (DL).Methods: A total of 206 patients with primary NPC who were diagnosed and treated at the Renmin Hospital of Wuhan University between June 2012 and January 2018 were retrospectively selected. A rectangular region of interest (ROI), which included the tumor area, surrounding tissues and organs, was delineated on each pre- and post-treatment MR image. Two InceptionResnetV2-based transfer learning models, named pre-model and post-model, were trained with the Pre-dataset and the Post-dataset, respectively. In addition, an ensemble learning model based on the pre-model and post-models was trained. The three established models were evaluated by receiver operating characteristic (ROC) analysis, confusion matrix, and Harrell’s concordance indices (C-index) after the model test. High-risk-related heat maps were developed according to the DL models.Results: The pre-model, post-model, and ensemble models displayed a C-index of 0.717 (95% CI: 0.639 to 0.795), 0.811 (95% CI: 0.745–0.877), 0.830 (95% CI: 0.767–0.893), and AUC of 0.745 (95% CI: 0.592–0.897), 0.820 (95% CI: 0.687–0.953), and 0.841 (95% CI: 0.715–0.968) for the test cohort, respectively. In comparison with the models, the post-model performance was better than the pre-model, which indicated the importance of post-treatment images for prognosis prediction. All three DL models performed better than the TNM staging system. The captured features presented on heat maps showed that the areas around the tumor and lymph nodes were related to the prognosis of the tumor.Conclusions: The three established DL models based on pre- and post-treatment MR images have a better performance than TNM staging. Post-treatment MR images are of great significance for prognosis prediction and could contribute to clinical decision-making.
Maternal Experience of Intermittent Kangaroo Mother Care for Late Preterm Infants: A Mixed-Methods Study in Four Postnatal Wards in China
Authors: Zhang Bo , Yue Jieya , Duan Zhiying , Zhao Yingxi , Williams Sarah , Huang Limin , Zhang Xiaoqin , Wu Wenli , Zhang Lin , Liu Jun , Zhao Gengli 
Published: November 2020

Abstract
Objective: To describe how mothers of late preterm infants experienced provision of intermittent kangaroo mother care (KMC) on four postnatal wards in different hospitals in China under a pilot KMC project.Methods: We used a concurrent mixed-methods approach incorporating quantitative and qualitative data. We collected quantitative data covering delivery and maternal experience of and attitude to KMC from 752 mothers who provided KMC to their late preterm newborns on the postnatal wards of four hospitals in different provinces of China. We gathered data from hospital records and maternal questionnaires. Qualitative data was collected from ten semi-structured interviews with nurses, obstetricians, and mothers from two of the participating postnatal wards. We used descriptive analysis for quantitative data and general inductive analysis for qualitative data.Results: Most mothers had not heard of KMC before being introduced to it on the postnatal ward. On average, mothers and newborns stayed on postnatal wards for 3.6 days: during their stay mothers provided an average of 3.5 KMC sessions, an average of 1.1 sessions a day. Each KMC session lasted an average of 68 minutes though there was much variation in length. Common reasons given for discontinuing a KMC session included restroom use, infant crying, and perceived time limitations. Some mothers would have preferred to provide KMC for longer periods of time and nurses encouraged this. Most mothers experienced no difficulty providing KMC, received support from family and medical staff and intended to continue KMC post discharge.Conclusion: In order to improve maternal experience of KMC it is recommended that awareness raising of KMC be included in antenatal care and after birth, longer periods of KMC provision be encouraged, greater privacy be provided for mothers providing KMC on postnatal wards and family members be encouraged to support KMC.
The Lived Experiences of Pregnant Women During COVID-19 Pandemic: A Descriptive Phenomenological Study
Authors: Mortazavi Forough , Ghardashi Fatemeh 
Published: November 2020

Abstract
BackgroundWith the onset of the COVID-19 epidemic, pregnancy and childbirth for women are taking place in unusual circumstances. We explored the lived experiences of pregnant women during the COVID-19 pandemic to better understand their experience of pregnancy so that better support could be provided.MethodsWe used a descriptive phenomenological approach to understand the lived experience of pregnant women in COVID-19 pandemic. We collected data using a purposive sampling method through in-depth interviews in cyberspace with a semi-structured questionnaire. We used Colaizzi’s seven-step content analysis method to analyze the research data with the help of MAXQDA software version 2020.ResultsWe conducted this descriptive phenomenology study on 19 pregnant women in a period between the 10th to the 20th of May, 2020. The participating women were already pregnant when the first signs of the epidemic appeared in the country and at the time of the interview. We acquired four themes including disruption of the tranquility and regular routines of daily life, new challenges caused by the epidemic, resilience and strength in facing the crisis, and adaptation with new conditions.ConclusionsThe psychological condition of women has deteriorated during the COVID-19 epidemic. The general mobilization the health system is necessary for alleviating pregnant women's difficulties in situations like the COVID-19 epidemic. Planning to establish virtual training classes, virtual counseling, and creating a safe and supportive community environment are among the most effective ways to enhance the peace and tranquility of pregnant women.
Hepatitis B Virus Antibody as Potential Biomarker to Predict the Effect of Rituximab in Diffuse Large B-cell Lymphoma Patients
Authors: Hu Shunfeng , Chen Na , Lu Kang , Zhen Changqing , Sui Xiaohui , Fang Xiaosheng , Li Ying , Zhou Xiangxiang , Wang Xin 
Published: November 2020

Abstract
Background: Diffuse large B-cell lymphoma (DLBCL) has been correlated with virus infection and immunity status. Hepatitis B virus (HBV) infection is a significant public health problem around the world, especially in China. Previous research regarding the association of non-Hodgkin lymphoma (NHL) and HBV mostly focused on HBV antigen and HBV DNA. This study aimed to evaluate the relationship between HBV antibody and clinical prognosis in DLBCL. Methods: We retrospectively investigated the clinical characteristics of 190 newly diagnosed and untreated DLBCL patients and did a follow-up study. Results: Compared with HBeAb- patients, HBeAb+ patients displayed unique clinical features, such as more advanced disease stage (p=0.031) and higher International Prognostic Index (IPI) score (p=0.015). HBV antibody-negative patients had better therapeutic efficiency than positive patients (p<0.05). The media progression-free survival (PFS) and overall survival (OS) of HBV antibody-positive group were shorter than the negative group, respectively (p<0.05). Furthermore, we found positive association between CD21 and HBsAb (p=0.06) and their synergistic effect for prognostic predication. Interestingly, the effect of Rituximab in prognostic improvement was more significant in HBV antibody-positive group than negative group. Univariate analysis showed that HBV antibody status was independent risk factor for prognosis of DLBCL patients. Conclusions: Taken together, our investigations identified for the first time the close association between HBV antibody and clinical prognosis and Rituximab responses in DLBCL patients. These findings indicate the novel association between HBV infection and DLBCL prognosis, provide potential biomarker to predict the effect of Rituximab, and offer novel insights into the role of immune response to HBV infection in DLBCL progression.
LncRNA NORAD promotes the progression of myocardial infarction by targeting miR-22-3p/PTEN axis
Authors: Li Chunxia , Zhang Lihui , Bu Xingpeng , Chu Guofang , Zhao Xiaofang , Liu Yaru 
Published: November 2020

Abstract
Increasing evidences have demonstrated that lncRNAs are closely associated with the progression of acute myocardial infarction (AMI). Although lncRNA NORAD has been reported to be highly expressed in MI patients, its specific function remains unclear. Here, we found that downregulation of NORAD efficiently attenuated heart damage in an AMI rat model. Meanwhile, silencing of NORAD also inhibited hypoxia/re-oxygenation (H/R)-treated mouse cardiomyocyte cell line HL-1 cells. Further, bioinformatics analysis revealed that NORAD might act as a ceRNA of miR-22-3p, and PTEN was a potential target of miR-22-3p. Then luciferase reporter assay was performed to confirm that NORAD could upregulate PTEN by directly sponging miR-22-3p. Meanwhile, miR-22-3p inhibitor significantly reversed si-NORAD induced inhibitory effect on the apoptosis of H/R-treated HL-1 cells, and overexpression of PTEN could obviously reverse miR-22-3p mimics induced inhibitory effect on the apoptosis of H/R-treated HL-1 cells. Meanwhile, miR-22-3p mimics significantly reversed OE-NORAD (overexpression of NORAD) induced expression of p-AKT and p-mTOR. In a word, our results suggested lncRNA NORAD might promote the progression of myocardial infarction by promoting PTEN/AKT/mTOR signaling pathway through directly sponging miR-22-3p, suggesting that NORAD might be a potential target for AMI treatment.
Covid-19 Pandemic Impact on Maternal and Child Health Services Access in Nampula, Mozambique: A Mixed Methods Research.
Authors: Pires Paulo das Neves , Macaringue Cynthia , Abdirazak Ahmed , Mucufo Jaibo , Mupueleque Martins , Siemens Ronald , Belo Celso 
Published: November 2020

Abstract
BackgroundThe Covid-19 pandemic limited access to health services in most countries, impacting negatively global health. Last March 2020 in Mozambique, a public state of emergency restrained people’s movements, reduced public services, and launched a national information campaign. The Alert Community for a Prepared Hospital implementation research, has been promoting access to maternal and child health care, at Marrere General Hospital and Marrere Health Centre, in Natikiri, Nampula, the city with the third highest incidence of Covid-19 in Mozambique. Our research aimed to assess the impact of Covid-19 on access to maternal and children health services in Nampula and estimate Alert Community for a Prepared Hospital project sustainability.MethodsMixed-methods research, descriptive, cross-sectional, and retrospective, using review of patient visits documentation, comparing March to May 2019 to same months in 2020, and interviews with health professionals, traditional birth attendants and patients. We involved two health centres and two hospitals. The two Marrere centres were Alert Community for a Prepared Hospital intervention centres, and the other two were control centres, compared using KrushKall Wallis, One-way Anova, mean and standard deviation tests.ResultsComparing 2019 maternal health services indicators with those from 2020, the intervention area had decreases of 28% in family planning visits, 26% in women in first ante-natal visits in the first trimester, and a 74% increase in home deliveries, all without statistical significance. The decrease in hospital maternity deliveries (4%) was statistically significant (p=0.046). The non-intervention area showed a decrease in women in first ante-natal visits in the first trimester (12%). Concerning child health, the intervention area had a 20% reduction in children presenting for vaccination and an 18% in children completely vaccinated, comparable to a reduction of 16% in the non-intervention area. Interviews revealed that most health professionals, traditional birth attendants and patients, have adequate knowledge about Covid-19. ConclusionOur results demonstrate negative collateral effects of Covid-19 on maternal and child health access and a deficient health information system in Mozambique. The Government’s media campaign promoting access to preventive health services, is not achieving its aim. The Alert Community project will need further research, to assess lasting effect on reducing the negative effects of Covid-19 on sexual and reproductive health.Trial registrationThis study was not registered in any data base.
Measuring equity of access to health services in practice: test and application of existing measuring tools in eye health outreach camps in rural Malawi
Authors: Trotignon Guillaume , Jones Iain , Ali Shaneez Saeed , Mugwang’a Ziporah , Engels Thomas , Bechange Stevens , Kamwendo Effie , Schmidt Elena , Adera Tesfaye Haileselassie 
Published: November 2020

Abstract
Introduction: Equity in the access and use of health services is critical if countries are to make progress towards universal health coverage and address the systematic exclusion of the most vulnerable groups. The purpose of this study was to test the feasibility of existing wealth measurement tools and functional disability questions to assess if the Co-ordinated Approach To Community Health programme implemented by Sightsavers was successful in reaching the poorest population and people living with disabilities in Kasungu district, Malawi. Methods: Between April and September 2017, data on socio-economic status, household characteristics and functional disability were collected from patients attending at eye camps in Kasungu district, Malawi. Using asset-based tools to measure household wealth (EquityTool© and Simple Poverty Scorecard©) and the Washington Group Short Set of Questions, individuals were categorised by wealth quintiles, poverty status, and functional disability status and then compared to relevant representative national household surveys. A follow-up household survey was conducted to check the validity of self-reported household characteristics at eye camps. Results: A total of 1,358 individuals participated in the study. The study shows that self-reported data on household characteristics and assets are reliable and can be collected in clinical settings (instead of relying on direct observations of assets). Individuals attending outreach camps were poorer in terms of relative wealth and absolute poverty rates compared to the rest of the population in Kasungu. It was estimated that 9% of the participants belonged to the poorest quintile compared to 4% for the population in Kasungu (DHS 2015-2016). The ultra-poverty rate was also lower among respondents (13%) compared to 15% for Kasungu district (IHS 2017). The functional disability rate was 27.5% for study participants, and statistically higher than the general population (5.6%, SENTIF 2017). Conclusions: Our study shows that existing tools can be reliably used, and combined, if based on recent population data, to assess equity of access to health services for vulnerable groups of the population. The findings suggest that the programme was successful in reaching the poorest people of the Kasungu district population as well as those with disabilities through outreach camps. However, it is essential to use sub-national data (district or regional level) from recent surveys for the purpose of benchmarking in order to produce accurate results.
A critical transcription factor NF-κB as a cancer therapeutic target and its inhibitors as cancer treatment options
Authors: Suhail Mohd , Tarique Mohammad , Muhammad Naoshad , Naz Huma , Hafeez Abdul , Zughaibi Torki A. , Kamal Mohammad Amjad , Rehan Mohd 
Published: November 2020

:
Nuclear Factor-κappa B (NF-κB) is a family of critical transcription factors of inflammatory pathway and plays
an imperative role in the progression of various cancers such as breast, lung, liver, pancreatic, prostate and multiple types of
lymphoma. NF-κB develops an inherent relationship between inflammation and cancer. It is a crucial factor which controls
the ability of malignant and pre-neoplastic cells to prevent programmed cell death-based tumor-surveillance channels. Due
to its high significance in the onset and progression of various cancers, it has become an excellent target for cancer therapy.
The emerging targeted therapies provide a lot of hope, whereby a single protein or generally the target enzyme is completely
blocked. Several natural compounds have shown anticancer and anti-inflammatory activities by inhibiting NF-κB pathway
in various cancer types. About 750 natural and synthetic inhibitors of the NF-κB have been reported. These inhibitors include microbial and viral proteins, small RNA/DNA, antioxidants, small molecules, peptides, and engineered constitutively
active polypeptides, all of which may inhibit canonical and alternative NF-κB pathways. Thus, blocking or targeting the NFκB-signaling pathways by using natural and synthetic compounds could be a potential mechanism to cure the NF-κB induced tumors.