bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of immune-related endoplasmic reticulum stress genes in sepsis-induced cardiomyopathy: Novel insights from bioinformatics analysis
Authors: Zhen Wan-Jing , Zhang Yan , Fu Wei-Dong , Fu Xiao-Lei , Yan Xin 
Published: December 2024

Background
The current study aims to elucidate the key molecular mechanisms linked to endoplasmic reticulum stress (ERS) in the pathogenesis of sepsis-induced cardiomyopathy (SIC) and offer innovative therapeutic targets for SIC.

Methods
The study downloaded dataset GSE79962 from the Gene Expression Omnibus database and acquired the ERS-related gene set from GeneCards. It utilized weighted gene co-expression network analysis (WGCNA) and conducted differential expression analysis to identify key modules and genes associated with SIC. The SIC hub genes were determined by the intersection of WGCNA-based hubs, DEGs, and ERS-related genes, followed by protein-protein interaction (PPI) network construction. Enrichment analyses, encompassing GO, KEGG, GSEA, and GSVA, were performed to elucidate potential biological pathways. The CIBERSORT algorithm was employed to analyze immune infiltration patterns. Diagnostic and prognostic models were developed to assess the clinical significance of hub genes in SIC. Additionally, in vivo experiments were conducted to validate the expression of hub genes.

Results
Differential analysis revealed 1031 differentially expressed genes (DEGs), while WGCNA identified a hub module with 1327 key genes. Subsequently, 13 hub genes were pinpointed by intersecting with ERS-related genes. NOX4, PDHB, SCP2, ACTC1, DLAT, EDN1, and NSDHL emerged as hub ERS-related genes through the protein-protein interaction network, with their diagnostic values confirmed via ROC curves. Diagnostic models incorporating five genes (NOX4, PDHB, ACTC1, DLAT, NSDHL) were validated using the LASSO algorithm, highlighting only the prognostic significance of serum PDHB levels in predicting the survival of septic patients. Additionally, decreased PDHB mRNA and protein expression levels were observed in the cardiac tissue of septic mice compared to control mice.

Conclusions
This study elucidated the interplay between metabolism and the immune microenvironment in SIC, providing fresh perspectives on the investigation of potential SIC pathogenesis. PDHB emerged as a significant biomarker of SIC, with implications on its progression through the regulation of ERS and metabolism.
Nursing Home Admission and Home Care Initiation After Acute Aortic Dissection: A Nationwide Registry-Based Cohort Study
Authors: Pedersen Maria Weinkouff , Oksjoki Riina , Møller Jacob Eifer , Gundlund Anna , Fosbøl Emil , Nielsen Dorte Guldbrand , Køber Lars , Andersen Mikkel Porsborg , Torp-Pedersen Christian , Søgaard Peter , Andersen Niels Holmark , Kragholm Kristian 
Published: December 2024

Abstract

Background:
Little is known about long-term outcomes beyond survival following acute aortic dissection. The aim of this research was to evaluate rates of home care initiation and nursing home admission during the first year after discharge and to assess factors associated with these needs.

Methods:
All patients in Denmark with a first-time diagnosis of acute aortic dissection type A or B between 2006 and 2015 were identified using national registries. Patients discharged alive without nursing home or home care use before aortic dissection were included, along with age-matched and sex-matched population controls without aortic dissection (at a ratio of 1:5). Cause-specific multivariable Cox regression was used to derive adjusted hazard ratios.

Results:
The study population comprised 1093 patients and 5465 control individuals with a median (IQR) age of 64 (55-71) years; 70.6% were men. During their hospital stay, 2.7% of patients were registered with a first-time diagnosis of stroke, 7.1% with heart failure, and 2.2% with acute kidney failure; 5.9% of patients needed first-time dialysis. During the first year after discharge, 0.8% of patients who had had aortic dissection were admitted to a nursing home, 7.8% started home care, and 5.9% died. Among controls, these rates were 0.2%, 1.2%, and 1.2%, respectively. Patients who had had aortic dissection had significantly increased risk of initiating home care (hazard ratio, 7.47 [95% CI, 5.38-18.37]; P < .001) and of being admitted to a nursing home (hazard ratio, 4.28 [95% CI, 1.73-10.59]; P = .001). Initiation of home care and nursing home admission were related to advanced age, female sex, preexisting comorbidities, in-hospital complications, and conservative management of type A aortic dissection.

Conclusion:
Only a small proportion of patients who survived an aortic dissection needed home care or nursing home admission after hospital discharge.
Codling moth management by low doses of sugars on the Royal Gala variety
Authors: Tiffrent Abdelkader , Lombarkia Nadia 
Published: December 2024

Codling mo th (CM) is a key pest in apple orchards in Algeria. Its control is difficult because of its ability to develop resistance to pesticides. Besides, concern about the safety of these pesticides for human health and the environment has led to regulatory actions that have reduced the availability of these products to growers. Thus, the use of eco-friendly alternative methods is encouraged. In this context, foliar spraying using fructose (100 ppm) and glucose (100 ppm) against CM larval stages on the Royal Gala variety, compared to the control and insecticide (Deltamethrin), was assessed in an orchard located in Beni Fedhala province (Batna-Algeria). The obtained results confirmed that the spraying of glucose and fructose increased the percentage of healthy fruits at harvest, the percentages of healthy fallen fruits and the total healthy fruits. Further, the number of diapausing larvae in corrugated cardboard banding was reduced. In addition, our study shows that the number of chrysalis was significantly lower and different from the number of male and female larvae, which are identical.
Combined effects of deficit irrigation and biochar application on seed yield and its components in three different sesame varieties grown in sandy soil conditions
Authors: Abdelsatar Mohamed Ali , Emam Mohamed A. , Elareny Ibrahim. M. , HASSONA Mohamed M. , El-Demardash Ibthal S. 
Published: December 2024

To answer the question, "Is biochar application considered an effective tool for mitigating the negative impacts of water stress on sesame production?" So, two experiments were conducted at the Ismailia Agricultural Research Station in Egypt during summer 2022 and 2023. For each irrigation regime, the experiment was conducted in a randomized complete block design using a split-plot arrangement with three replications. The main plots received biochar application rates, while sub-plots planted sesame varieties. The study found that deficit irrigation combined with biochar application significantly improved seed yield and its components in all three sesame varieties. The combination of deficit irrigation with biochar application was found to be a sustainable approach for improving sesame production in sandy soil conditions. Furthermore, biochar application had proven its ability to mitigate the negative effects of deficit irrigation, resulting in higher seed yields.
Health implications of racial differences in serum growth differentiation factor levels among men with obesity
Authors: Bathina Siresha , Lopez Virginia Fuenmayor , Prado Mia , Ballato Elliot , Colleluori Georgia , Tetlay Maryam , Villareal Dennis T , Mediwala Sanjay , Chen Rui , Qualls Clifford , Armamento‐Villareal Reina 
Published: December 2024

AbstractGrowth differentiation factor (GDF15) has been considered a biomarker and recently a hormonal driver for diseases in different populations. However, the role of GDF15 as a biomarker of health outcomes in obese men from different racial/ethnic background has not been evaluated. The objective of this study was to investigate the racial/ethnic differences on the relationship between GDF15 and markers of glucometabolic status, hormonal profile, body composition and bone mineral density (BMD) in obese men. One hundred ninety‐three obese men from diverse racial/ethnic backgrounds were enrolled. BMD and body composition were measured by dual energy X‐ray absorptiometry. Serum GDF15, osteocalcin, C‐terminal telopeptide, sclerostin, adiponectin, leptin, estradiol, testosterone, follicle‐stimulating hormone, luteinizing hormone, 25‐hydroxyvitamin D, lipid profile, and hemoglobin A1C (A1C) were measured. Non‐African Americans (NAA) had significantly higher GDF15 level than African Americans (AA). Level was also higher in patients with type 2 diabetes (T2DM). In both the groups GDF15 correlated with A1C and lean mass. However. GDF15 correlated with body fat, LDL total cholesterol and femoral neck BMD only in NAA and with appendicular lean mass only in AA. Ethnicity, total cholesterol and T2DM were found to be independent predictors of GDF15. We conclude that GDF15 may influence glucometabolic status, body composition and bone parameters which may affect cardiovascular risk and osteoporosis between races.
Trim13‐induced ubiquitination of RPS27A inhibits the progression of lung cancer by depending on the inactivation of NF‐κB signaling pathway
Authors: Li Lailing , Zhou Hui , Cui Yayun , Xu Ke 
Published: December 2024

AbstractLung cancer (LC) is the leading cause of cancer‐related death worldwide. Recent studies have shown that tripartite motif 13 (TRIM13) play important regulatory roles in the progression of different tumors. In this study, we focused on the role of TRIM13 in LC tumorigenesis and its underlying molecular mechanisms. The study demonstrated TRIM13 was identified as a novel tumor suppressor gene of LC and its overexpression suppressed LC progression in vitro and in vivo. Mechanistically, TRIM13 interacted with RPS27A, increasing RPS27A ubiquitination and degradation. Furthermore, RPS27A overexpression reversed the inhibitory effect of TRIM13 overexpression on LC progression. By binding to RPS27A and encouraging its ubiquitination and degradation, TRIM13 hindered LC advancement. We also found that RPS27A overexpression reversed the inhibitory effect of TRIM13 overexpression on NF‐κB signaling, thereby further promoting the proliferation and metastasis of LC cell lines. Therefore, targeting the TRIM13/RPS27A/NF‐κB signaling axis may be a promising target for LC treatment.
Lexical patterns in Hungarian vowel harmony
Authors: Rácz Péter , Rebrus Péter 
Published: December 2024

Abstract
Hungarian shows variable front vowel harmony, particularly in suffixed back vowel + [ɛ] nouns. The study aims to address two main research questions: (1) To what extent does stem-level information (similarity across stems) predict suffix variation for back vowel + [ɛ] stems in Hungarian corpus data? (2) Do suffixes themselves predict suffix variation beyond the stem-level information? We draw on a dataset of 200 noun stems, 4,501 suffixed forms and 4 × 106 tokens, based on the New Hungarian Webcorpus, and use a K-Nearest Neighbours learner and a hierarchical generalised linear model to address these questions. We find that the majority of back vowel + [ɛ] stems show variable vowel harmony, that this depends on stem similarity and that similarity effects are amplified by vowel-initial suffixes. This points to a model of Hungarian vowel harmony in which stem- and suffix-level information are lexically specified.
Demystifying multiple sclerosis diagnosis using interpretable and understandable artificial intelligence
Authors: Chadaga Krishnaraj , Khanna Varada Vivek , Prabhu Srikanth , Sampathila Niranjana , Chadaga Rajagopala , Palkar Anisha 
Published: December 2024

Abstract
Multiple sclerosis (MS) is a dangerous illness that strikes the central nervous system. The body’s immune system attacks myelin (an entity above the nerves) and impairs brain-to-body communication. To date, it is not possible to cure MS. However, symptoms can be managed, and treatments can be provided if the disease is diagnosed early. Hence, supervised machine learning (ML) algorithms and several hyperparameter tuning techniques, including Bayesian optimization, have been utilized in this study to predict MS in patients. Descriptive and inferential statistical analysis has been conducted before training the classifiers. The most essential markers were chosen using a technique called mutual information. Among the search techniques, the Bayesian optimization search technique prevailed to be pre-eminent, with an accuracy of 89%. To comprehend the diagnosis generated by the ML classifiers, four techniques of explainable artificial intelligence were utilized. According to them, the crucial attributes are periventricular magnetic resonance imaging (MRI), infratentorial MRI, oligoclonal bands, spinal cord MRI, breastfeeding, varicella disease, and initial symptoms. The models could be deployed in various medical facilities to detect MS in patients. The doctors could also use this framework to get a second opinion regarding the diagnosis.
Phase characterisation in minerals and metals using an SEM-EDS based automated mineralogy system
Authors: Kostryzhev Andrii , Murphy Timothy 
Published: December 2024

Abstract
Advanced Mineral Identification and Characterisation System (AMICS) is based on energy dispersive X-ray spectroscopy (EDS) utilised in a scanning electron microscope (SEM). A specially designed software controls the sample positioning inside the microscope chamber, EDS spectra acquisition and analysis, phase identification, and results visualisation in the form of maps, graphs and tables. Characterisation can be conducted automatically for up to 28 mounted samples in a Hitachi SU3900 SEM with or without coating. Many options exist for an experienced researcher to influence the analysis process: (i) extract a spectrum for each acquisition point and determine chemical composition at this point, (ii) visualise mineral maps for each phase or a group of phases to characterise their interactions, (iii) determine the particle geometry-chemistry relationship, (iv) conduct statistical analysis of EDS spectra, define presence of solute elements, and visualise distribution of particles with a particular chemical composition, (v) manually develop the spectra database for unknown phases and solid solutions. This paper briefly outlines the AMICS software features and selected results for phase characterisation in minerals, metal alloys, and nanoparticle mixtures (MOFs and ZIFs). The influence of data acquisition methodology on accuracy and depth of characterisation is discussed.
UM CONVITE AO BRINCAR
Authors: Florêncio Samara Queiroz do Nascimento , Vasconcelos Josiane Barbosa de , Araújo Júnior Isnaldo Florêncio 
Published: December 2024

Este texto é uma resenha crítica do livro ‘Educação Física pela Pedagogia da Corporeidade: um convite ao brincar’, de autoria de Pierre Normando Gomes-da-Silva, autor que vem abordando a Educação Física por meio da linguagem pragmática e ontológica e que teoriza a Pedagogia da Corporeidade como um método de ensino e de pesquisa, que pode ser aplicado na educação e na saúde. O livro é um convite para que os professores leitores o acompanhem na brincadeira de ensinar, de modo mais leve, divertido, sistemático, crítico e criativo, enfim, mais inteligente e saudável.
IMPRESSOS ESCOLARES E A RELIGIÃO CATÓLICA
Authors: Lopez Gomes Cristian , Do Valle Pereira Assis Jacira Helena 
Published: December 2024

Este artigo tem como objetivo apresentar resultados de uma revisão sistemática no campo da História da Educação, referente a impressos escolares e sua vinculação com a religião católica. Na produção científica levantada, foram analisados os referenciais teóricos adotados, o enfoque dado e as regiões do país que abordavam essa temática. Na presente investigação, optou-se pela utilização do software de revisão sistemática Sumarize. Os resultados sinalizam que os referenciais mais mobilizados foram vinculados à História Cultural, e há forte presença dos conteúdos informados por uma perspectiva católica nos impressos escolares, sendo que essa concentração é maior na região sul do país.
PARA QUAL ESCOLA VOCÊ DEVE ENVIAR OS SEUS FILHOS? AUF WELCHE SCHULE SIE IHRE KINDER SCHICKEN SOLLTEN?
Authors: Peter da Fonseca Maria Angela , Callegaro Tambara Elomar Antonio 
Published: December 2024

O objetivo deste artigo é mapear comportamentos doutrinários, ideológicos, e pedagógicos presentes na cultura escolar de duas Deutsche Schulen (Escolas Alemãs) urbanas, instituições escolares localizadas nas cidades de Pelotas, Brasil e Buenos Aires, Argentina (1900-1930). As fontes principais são Relatórios de Jubileus Comemorativos das duas instituições. Trata-se de pesquisa bibliográfica, documental e qualitativa que utiliza os referenciais teóricos-epistemológicos da História Cultural e História Conectada. Cultura escolar e tradições étnicas com vistas à continuidade do Deutschtum mesclaram-se sincronicamente ao cotidiano de alunos teuto-brasileiros e teuto-argentinos no início do século XX.
An Electrically Evoked Compound Action Potential Marker for Local Spiral Ganglion Neuron Degeneration: The Failure Index
Authors: Konerding Wiebke , Arenberg Julie , Sznabel Dorota , Kral Andrej , Baumhoff Peter 
Published: December 2024

Spiral ganglion neuron (SGN) degeneration is a candidate factor for reduced hearing outcomes in cochlear implant (CI) users. However, there is no procedure available to identify CI contacts close to focal SGN degeneration in human patients. In an animal model, we assessed the impact of focal SGN degeneration on electrical responsiveness and derived an electrophysiological marker for the presence, location, and size of such lesions. We introduced cochlear microlesions in 13 guinea pigs (six female) and recorded electrically evoked compound action potentials (eCAP) after 8–12 d. These were compared with recordings from controls (
N
= 8) and acutely lesioned cochleae (
N
= 12). We stimulated via 6-contact CIs in monopolar configuration with symmetric, biphasic pulses of alternating polarity. We histologically assessed the lesion and its relative position to the CI contacts. The lesions (230–850 µm) significantly elevated thresholds and reduced amplitudes. The effect was found at stimulation distances of 3.5 mm from the lesion. A novel eCAP marker, Failure Index (FI: maximal input/output ratio), was significantly elevated in the presence of degenerated SGN. It indicates the failure to efficiently transduce the stimulation current into neural activation (N1P1 amplitude). The FI showed classification accuracies of 80% and identified contacts closest to the lesion in ∼80% of cases within ±700 µm (∼electrode spacing) from the lesion site and was correlated with the lesion size. Thus, the FI is a clinically relevant, noninvasive marker that is suitable for clinical datasets without a priori knowledge on lesions, when combined with the statistical method of median splitting.
Die neuen Eignungsanforderungen an Leitungsorgane und Inhaber von Schlüsselfunktionen nach dem Bankenpaket
Authors: Nemeczek Heinrich 
Published: December 2024

Zusammenfassung
Mit dem Bankenpaket wurden die Eignungsanforderungen für Mitglieder des Leitungsorgans weiter konkretisiert und für Inhaber von Schlüsselfunktionen gesetzlich begründet. Der europäische Gesetzgeber wollte damit die gegenwärtig „fragmentierte Regulierungslandschaft“ weiter eindämmen. Die Auswirkungen bleiben jedoch für das deutsche Aufsichtsrecht verhältnismäßig überschaubar. Relevant werden diese insbesondere in der Erstreckung der Eignungsanforderungen auf zugelassene (gemischte) Finanzholdinggesellschaften sowie auf Inhaber von Schlüsselfunktionen.
Anlageverhalten und Kundenprofile im Vergleich: Unterschiede zwischen Sparkassen, Genossenschaftsbanken und Großbanken
Authors: Becker Martin G. , Walter Andreas 
Published: December 2024

Zusammenfassung
Traditionell unterhalten Haushalte in Deutschland eine Hausbankbeziehung zu einer Filialbank, die einer der drei Gruppen der Universalbanken angehört: einer Sparkasse, einer Genossenschaftsbank oder einer Großbank. Diese Studie zielt darauf ab, erstmals die strukturellen Unterschiede in der Kundenbasis und im Anlageverhalten zwischen den drei Bankengruppen systematisch zu dokumentieren. Ein besonderes Augenmerk liegt auf der Frage, ob Kunden von Sparkassen und Genossenschaftsbanken im Vergleich zu Großbankkunden konservativer investieren und einen größeren Anteil ihres Finanzvermögens in Bankeinlagen halten. Darüber hinaus wird untersucht, ob die Zugehörigkeit zu einer bestimmten Bankengruppe einen signifikanten Einfluss auf die Aktienmarktpartizipation und das generelle Anlageverhalten besitzt oder ob diese Abweichungen durch Unterschiede in der Kundenstruktur zwischen den Instituten erklärt werden können.
Roman stamped bricks from Brigetio from the 1927–1929 excavations of István Paulovics
Authors: Dobosi Linda , Szabadváry Tamás 
Published: December 2024

AbstractModern topographical research in and around the legionary fortress of Brigetio (Komárom/Szőny, Hungary) started in the 1920s motivated by the desire to stop the centuries-long archaeological lootings at the site and to prevent further loss of archaeological data caused by the uncontrolled removal and selling of artefacts. The excavations led by István Paulovics between 1927 and 1929 touched upon the northern surrounding wall of the castra, a short section of the via decumana south of the fortress and parts of the late Roman cemeteries southeast of the fortress. During the excavation 67 stamped bricks and tiles were collected and taken to the Hungarian National Museum. Forty-five of them were mentioned in the 1933 brick stamp corpus of J. Szilágyi, but 22 have never been published. The significance of the material is twofold. On the one hand it yielded a wide array of Valentinian tile stamps, for example the stamps of Lupicinus tribunus, Terentianus tribunus, Caris tribunus, Verianus tribunus, Corta Vicen, Quadriburgium, and Vincentia. On the other hand, 27 of the 43 legio I Adiutrix stamps (the garrison of Brigetio between the early second and early fifth centuries AD) came from late Roman archaeological contexts, which means that some of the types of the otherwise undatable legio I Adiutrix stamps can now be dated with reasonable probability to the fourth century.
Norico-Pannonian winged brooches from Brigetio
Authors: Sáró Csilla 
Published: December 2024

AbstractThis paper aims to present twenty-one Norico-Pannonian winged brooches from Brigetio. It focuses on their typological details, distribution areas, and chronology. Wearing habits can also be investigated based on burials and tombstone depictions. This paper also contributes to the manufacturing process and workshops of the variants from Brigetio.