bluuebunny/crossref_metadata_2025_split huggingface dataset:
Australians with intellectual disability share their experiences of retirement from mainstream employment
Authors: Brotherton Michelle , Stancliffe Roger J. , Wilson Nathan J. , O'Loughlin Kate 
Published: February 2020

AbstractBackgroundAs part of a larger study exploring the transition to retirement for people with intellectual disability from a working life in mainstream employment, this paper reports on retirement from the perspective of those who have already retired.MethodSemi‐structured interviews were undertaken with five Australian retirees with intellectual disability. Data were analysed using grounded theory methodology. Employment service records provided background information on participants' employment and supports.ResultsRetirement occurred as the solution to ongoing problems primarily related to health. Retirement decisions were made in conjunction with family and support staff, with participants reporting varying levels of self‐determination in the process, and mixed feelings about their retirement. None of the participants were participating in mainstream community groups in retirement.ConclusionsThere is a need for retirement preparation for this emerging population to support self‐determination in retirement‐related decisions including individualized training to facilitate independent participation in mainstream social activities in retirement.
Hyperlipidemia inhibits the protective effect of lisinopril after myocardial infarction via activation of dendritic cells
Authors: Ma Yuanji , Ma Leilei , Ma Jiaqi , Wu Runda , Zou Yunzeng , Ge Junbo 
Published: February 2020

AbstractTo investigate the prevention of cardiac remodelling and inflammatory immune response after myocardial infarction (MI) via ACEI regulating dendritic cells (DCs), we explored whether the protective effect of ACEI was repressed under hyperlipidemic environment. In vivo, the survival rate and left ventricular function of the mice were recorded on day 7 after MI. Tissue samples of the myocardium, spleen, bone marrow and peripheral blood were assessed for Ang II concentration, inflammatory cytokines and DCs expression. In vitro, DCs were treated with ox‐LDL + Ang II, simulating the internal environment of MI in ApoE−/− mice to explore the mechanism involved in the DCs maturation and inflammation. Under hyperlipidemic circumstances, we found that the cardioprotective effect of ACEI was attenuated through regulating DCs maturation and inflammation after MI, affecting survival rate and left ventricular function. Effects of lisinopril on the release of spleen‐derived DCs and myocardial infiltration were also reduced under hyperlipidemic conditions. In vitro, immune maturation and inflammation of DCs were further induced by ox‐LDL on the basis of Ang II treatment, as indicated by the upregulation of CD83, CD86, and the expressions of cytokines and chemokines. Furthermore, ox‐LDL could activate TLR4‐MyD88 signalling pathway, promoting IRAK‐4 and NF‐κB. The present study demonstrated that ACEI reduced the recruitment of DCs to the infarct site, leading to a higher survival rate and improved function. However, this effect was inhibited under hyperlipidemic environment. TLR4‐MyD88 signalling pathway may be responsible for the molecular mechanism involved in the immune maturation and inflammation of DCs induced by ox‐LDL.
Effect of dietary supplementation of whey powder and Bacillus subtilis on growth performance, gut and hepatic function, and muscle antioxidant capacity of Japanese quail
Authors: Jazi Vahid , Farahi Majid , Khajali Fariborz , Abousaad Shaymma , Ferket Peter , Assadi Soumeh Elham 
Published: February 2020

AbstractThis experiment was conducted to evaluate the effects of dietary supplementation of whey powder (WP), Bacillus subtilis (BAS), and their combination (MIX) on growth performance, intestinal morphology, caecal microflora, hepatic gene expression, blood metabolites, and skeletal muscle antioxidant capacity in Japanese quails. A total of 400 one‐day‐old Japanese quails were randomly distributed to 20‐floor pens (4 dietary treatments, 5 replications per treatment, 20 birds per pen). The birds were fed a basal diet (control, CON) or the basal diet supplemented with 40 g/kg WP, 1 g/kg BAS probiotic or 40 g/kg WP plus 1 g/kg BAS probiotic for five weeks. Feed intake was not affected by the treatments at any stage of the trial. However, the WP, BAS, and MIX feed had better weight gain and feed conversion ratio compared to the CON during the entire production period (day 1–35; p < .05). Feeding the WP, BAS, and MIX diets caused no significant difference in morphometric measures in the duodenum, jejunum, and ileum other than the villus height to crypt depth ratio in the ileum (p < .05). The expression of insulin‐like growth factor‐1 (IGF‐1) and growth hormone genes was highly upregulated in the liver of the birds fed the MIX diet (p < .05). Feeding birds with the diets containing WP, BAS, and MIX increased the population of caecal lactic acid bacteria and reduced serum cholesterol concentration compared to the CON diet (p < .05). Likewise, the tested feed additives increased superoxide dismutase and glutathione peroxidase enzyme activities in the thigh muscle (p < .05). No synergistic effect was found between WP and BAS in studied parameters other than IGF‐1 gene expression. Improved growth performance of Japanese quails by feeding the WP, BAS, and the MIX feed could be linked to improved absorptive capacity of the small intestine as well as over‐expression of anabolic growth factors. In conclusion, WP with or without BAS could be considered as a beneficial dietary supplement to enhance productive performance, gut functionality, and antioxidant capacity of Japanese quail.
The effect of radiation exposure on the electrical conductivity of LDPE + x vol.%TlInSe2
Authors: Gojayev E. M. , Osmanova S. S. , Damirov A. H. , Safarova S. I. 
Published: February 2020

The paper presents results of studying temperature dependences of the specific volume resistance of nonirradiated and irradiated [Formula: see text]-rays with a different dose of [Formula: see text] vol.%TlInSe2 composites in the temperature range 300–380 K. The technique for modifying the structure of composites with semiconductor filler was carried out on a [Formula: see text]Co-type MPX [Formula: see text]-25 M isotope [Formula: see text]-emitter at a temperature of 300 K in vacuum ampoules at doses of [Formula: see text]–[Formula: see text] Gy. The electrical properties of the composites were studied before and after irradiation with [Formula: see text]-rays. Samples were prepared by mechanically mixing the filler [Formula: see text] powder with a low density polyethylene powder until obtaining a uniform mixture. The mixture is kept for 5 min at the melting temperature of the polymer under a pressure of 5 MPa. At the same temperature, by pressing a homogeneous mixture, the pressure rises to 15 MPa, at this pressure the sample is held for another 5 min, and then quickly cooled in water. The specific volume resistivity of the composites was measured using a DC bridge of the P-4053 type with additional measuring electrodes. Samples before testing are aged for 24 h at a temperature of [Formula: see text]C and a relative humidity of [Formula: see text]%. It was revealed that with an increase in the volume content [Formula: see text], the specific volume of resistivity of composites decreases. Under the action of [Formula: see text]-radiation and a change in the filler content, the magnitude and nature of [Formula: see text] dependence changes, and this allows to manage the physical parameters of studied composites by varying the filler content and [Formula: see text]-radiation dose.
Postpartum Involution and Cancer: An Opportunity for Targeted Breast Cancer Prevention and Treatments?
Authors: Borges Virginia F. , Lyons Traci R. , Germain Doris , Schedin Pepper 
Published: February 2020

Abstract
Childbirth at any age confers a transient increased risk for breast cancer in the first decade postpartum and this window of adverse effect extends over two decades in women with late-age first childbirth (&gt;35 years of age). Crossover to the protective effect of pregnancy is dependent on age at first pregnancy, with young mothers receiving the most benefit. Furthermore, breast cancer diagnosis during the 5- to 10-year postpartum window associates with high risk for subsequent metastatic disease. Notably, lactation has been shown to be protective against breast cancer incidence overall, with varying degrees of protection by race, multiparity, and lifetime duration of lactation. An effect for lactation on breast cancer outcome after diagnosis has not been described. We discuss the most recent data and mechanistic insights underlying these epidemiologic findings. Postpartum involution of the breast has been identified as a key mediator of the increased risk for metastasis in women diagnosed within 5–10 years of a completed pregnancy. During breast involution, immune avoidance, increased lymphatic network, extracellular matrix remodeling, and increased seeding to the liver and lymph node work as interconnected pathways, leading to the adverse effect of a postpartum diagnosis. We al discuss a novel mechanism underlying the protective effect of breastfeeding. Collectively, these mechanistic insights offer potential therapeutic avenues for the prevention and/or improved treatment of postpartum breast cancer.
Personality and attitudes towards people with mental disorders: Preliminary studies results
Authors: Wolska Aleksandra , Malina Alicja 
Published: February 2020

Background: The subject of psychological research all over the world is to understand the factors conditioning relationships between healthy people and people with mental disorders. Authors analysing attitudes towards people with mental disorders emphasize the importance of two types of determinants: personality factors and demographic and social variables. Aim: The aim of the research was to determine the interdependencies between personality traits and attitudes towards people with mental disorders, taking into account the moderating role of social distance and demographic and environmental variables. Method: Polish version of Community Attitudes towards Mental Illness (CAMI) – Kwestionariusz Postaw (KP) was used to measure attitudes towards people with mental disorders. Personality traits were measured using the NEO-Five-Factor Inventory (FFI) Personality Inventory by Costa and McCrae–Polish Adaptation, and the polish version of the Social Distance Scale was used to measure the declared social distance. In all, 204 people participated in the research: 133 women and 71 men, aged 18–65 years, living in the Kuyavian-Pomeranian and Greater Poland voivodeships. Results: The results showed that there is a relationship between personality traits: neuroticism, extraversion, openness to experience and agreeableness and an attitude towards people with mental disorders. Social distance, as the proposed moderator, did not significantly change the relationship between the variables. Conclusion: The results of the research have confirmed the important role of personality factors for attitudes, what should be remembered to exploration of presented phenomenon.
Open Surgical Excision Versus Endoscopic Radiofrequency Ablation for Piriform Fossa Fistula
Authors: Pu Shilei , Li Wanpeng , Xu Hongming , Zhao Liming , Liu Xiaojun , Li Xiaoyan 
Published: February 2020

Objectives: The purpose of this study is to explore the curative effect of open surgical excision and endoscopic radiofrequency ablation (RA) in the treatment of piriform fossa fistula (PSF). Methods: Retrospective study of 80 cases of PSF in the Department of Otolaryngology-Head and Neck Surgery, Shanghai Children’s Hospital, from June 2009 to June 2017. Results: In this series, there were 43 males and 37 females, and the mean age was 5.2 years (17 days to 12 years). Surgical excision was performed for 62 patients. Radiofrequency ablation was performed for 18 patients. Six cases of postoperative temporary hoarseness occurred, and the hoarseness rates were not significantly different between the excision and RA groups (6.4% vs 11.1%, respectively, P = .88). Two cases of temporary neck abscess occurred in the RA group. After the mean follow-up period of 3.1 years (1-8 years), no recurrence was found between the excision and RA groups. Conclusions: The curative effect of excision and RA for PSF is not significantly different; each of the 2 methods has its advantages and disadvantages. However, RA for PSF has the merit of being minimally invasive, easy to operate, and safe; this procedure seems to be more suitable in the clinic.
Impact of delayed systemic heparinization on postoperative bleeding and thromboembolism during post-cardiotomy extracorporeal membrane oxygenation in neonates
Authors: von Stumm Maria , Subbotina Irina , Biermann Daniel , Gottschalk Urda , Mueller Goetz , Kozlik-Feldmann Rainer , Reichenspurner Hermann , Riso Arlindo , Sachweh Joerg S 
Published: February 2020

Introduction: Veno-arterial extracorporeal membrane oxygenation is well-established for pediatric patients with post-cardiotomy heart failure. However, extracorporeal membrane oxygenation support is associated with major complications, that is, hemorrhage and thromboembolism. We seek to report our experience with delayed systemic heparinization during neonatal cardiac extracorporeal membrane oxygenation and its impact on bleeding and thromboembolism. Methods: We retrospectively identified 15 consecutive neonates who were placed on extracorporeal membrane oxygenation after congenital heart surgery during a period of 3 years (2015-2017). Our anticoagulation protocol consisted of full heparin reversal by protamine after switching from cardiopulmonary bypass to extracorporeal membrane oxygenation (target activated clotting time: 120 ± 20 seconds). Administration of systemic heparinization was delayed until postoperative drainage volume declined to <1 mL/kg/h. Primary study endpoints were thromboembolism, bleeding, and requirement of blood products on extracorporeal membrane oxygenation. Results: Our cohort (mean age: 13 ± 2.6 days; mean weight: 3.1 ± 0.3 kg; 66.7% male) required post-cardiotomy extracorporeal membrane oxygenation with a mean support time of 4.5 ± 2.2 days. Systemic heparinization was delayed averagely for 18.1 ± 9.3 hours. No thromboembolic events were observed on extracorporeal membrane oxygenation or after weaning. Relevant surgical site bleeding occurred in two patients (13.3%) requiring re-thoracotomy on the first postoperative day. Analysis of transfusion volumes revealed 24.5 ± 21.9 mL/kg/d mean packed red blood cells, 9.6 ± 7.1 mL/kg/d mean fresh frozen plasma, and 7.5 ± 5.7 mL/kg/d mean platelets. In-hospital survival was 86.6% (n = 13). Conclusion: In this retrospective analysis, the results of delayed systemic heparinization in neonatal post-cardiotomy extracorporeal membrane oxygenation could lead one to conclude that this routine is safe and favorable with low risk for thromboembolic events, reduced postoperative hemorrhage, and reduced blood product utilization.
Group-based music intervention in Parkinson’s disease – findings from a mixed-methods study
Authors: Pohl Petra , Wressle Ewa , Lundin Fredrik , Enthoven Paul , Dizdar Nil 
Published: February 2020

Objective: To evaluate a group-based music intervention in patients with Parkinson’s disease. Design: Parallel group randomized controlled trial with qualitative triangulation. Setting: Neurorehabilitation in primary care. Subjects: Forty-six patients with Parkinson’s disease were randomized into intervention group ( n = 26), which received training with the music-based intervention, and control group ( n = 20) without training. Interventions: The intervention was delivered twice weekly for 12 weeks. Main measures: Primary outcome was Timed-Up-and-Go subtracting serial 7’s (dual-task ability). Secondary outcomes were cognition, balance, concerns about falling, freezing of gait, and quality of life. All outcomes were evaluated at baseline, post-intervention, and three months post-intervention. Focus groups and individual interviews were conducted with the intervention group and with the delivering physiotherapists. Results: No between-group differences were observed for dual-task ability. Between-group differences were observed for Falls Efficacy Scale (mean difference (MD) = 6.5 points; 95% confidence interval (CI) = 3.0 to 10.0, P = 0.001) and for Parkinson Disease Questionnaire-39 items (MD = 8.3; 95% CI = 2.7 to 13.8, P = 0.005) when compared to the control group post-intervention, but these were not maintained at three months post-intervention. Three themes were derived from the interviews: Expectations versus Results, Perspectives on Treatment Contents, and Key Factors for Success. Conclusion: Patient-reported outcomes and interviews suggest that the group-based music intervention adds value to mood, alertness, and quality of life in patients with Parkinson’s disease. The study does not support the efficacy in producing immediate or lasting gains in dual-tasking, cognition, balance, or freezing of gait.
Resilience and lifestyle-related factors as predictors for health-related quality of life among early adolescents: a cross-sectional study
Authors: Bottolfs Marthe , Støa Eva Maria , Reinboth Michael Sæther , Svendsen Martin Veel , Schmidt Sabrina Krogh , Oellingrath Inger Margaret , Bratland-Sanda Solfrid 
Published: February 2020

Objective To examine whether lifestyle-related factors and resilience predict health-related quality of life (HRQoL) in a sample of early adolescents. Methods A total of 611 eighth grade pupils (response rate: 79%) participated in this cross-sectional study. The variables measured were physical activity (accelerometer), cardiorespiratory fitness (Andersen test) and a questionnaire assessing dietary habits, sleep disturbance, resilience (Resilience Scale for Adolescents) and HRQoL (KIDSCREEN-27). Results A total of 36% of the sample met the official recommendations of 60 minutes of daily physical activity. Univariate analysis identified physical activity, dietary habits, sleep disturbances, body mass index (BMI), cardiorespiratory fitness and resilience, but not sedentary time, as predictors of HRQoL. Multivariate regression analysis identified resilience as a positive predictor (β 0.18 to 0.27) of all HRQoL domains and sleep disturbance as a negative predictor (β −0.65 to −0.24) of four HRQoL domains. BMI (β = −0.27) and cardiorespiratory fitness (β = 0.021) were predictors of the HRQoL domain physical well-being. Adherence to dietary recommendations was both a positive and a negative predictor of HRQoL (β −0.45 to 0.59). Conclusion Resilience and sleep disturbances were the main predictors of HRQoL.
Association between thyroid hormone parameters during early pregnancy and gestational hypertension: a prospective cohort study
Authors: Lai Hua , Zhan Zheng-Yu , Liu Huai 
Published: February 2020

Objective Thyroid dysfunction may play a role in the development of gestational hypertension. However, this relationship remains unclear. This study was performed to evaluate the association between thyroid hormone parameters during early pregnancy and gestational hypertension. Methods Women with singleton pregnancies were recruited into this prospective cohort study at 9 to 13 gestational weeks, and their serum thyroid-stimulating hormone, free thyroxine, and free triiodothyronine concentrations were measured using electrochemiluminescence immunoassays. In total, 1226 participants were included in the final analysis. Results Of the 1226 participants, 81 subsequently developed gestational hypertension (overall incidence of 6.6%). Compared with women with euthyroidism, both pregnant women with hypothyroidism and those with subclinical hypothyroidism had an increased risk of gestational hypertension (adjusted odds ratio [OR], 3.61; 95% confidence interval [CI], 1.52–8.57 and OR, 2.24; 95% CI, 1.06–4.72, respectively). When the thyroid-stimulating hormone and free thyroxine concentrations were analyzed by quintiles, the women in the highest thyroid-stimulating hormone quintile had a higher risk of gestational hypertension (adjusted OR, 4.22; 95% CI, 1.78–9.05) than the women in the middle quintile. Conclusion Our results suggest that hypothyroidism, subclinical hypothyroidism, and a high thyroid-stimulating hormone concentration during early pregnancy are risk factors for gestational hypertension.
Outcomes of Multidetector Computed Tomography Pulmonary Angiography in Pregnant and Postpartum Women With Suspected Pulmonary Embolism
Authors: Sun Simon , Diaconescu Marius , Zhe Tian , Mesurolle Benoit , Semionov Alexandre 
Published: February 2020

Purpose: Verify whether there is a difference in likelihood of developing pulmonary embolism (PE) between pregnant women, nonpregnant women of reproductive age, and postpartum (up to 6 weeks) women, by comparing their outcomes on computed tomography pulmonary angiography (CTPA) done for suspicion of PE. Materials and Methods: Retrospective cohort study of 1463 CTPA done for suspicion of PE in females of reproductive age (18-40 years), nonpregnant, pregnant (antepartum), and postpartum, from 2 tertiary-care academic hospitals between October 2006 and September 2015. Primary outcome was diagnosis of PE on imaging. Additional assessment was made of technical adequacy of the studies and method of delivery for the postpartum cohort (vaginal vs caesarean birth). Twenty-nine technically nondiagnostic studies were excluded. The effect of any potential variable on PE status was tested using univariate logistic regression. Subgroup analysis was performed after excluding patients with independent risk factors for PE. Results: The rate of CTPA positive for PE was less among pregnant patients compared to early postpartum and nonpregnant women of similar age, 2.9% vs 11.5% and 10.3%, respectively. Pregnancy was associated with statistically significant decreased odds ratio of developing a PE on CTPA, 0.23 (0.09-0.89), P value = .004. After excluding patients with additional independent risk factors for PE, there was no statistically significant odds ratio association between presence of PE on CTPA and pregnancy 0.41 (0.13-1.34), P value = .14. Conclusion: Rate of CTPA positive for PE in pregnant women was lower than in nonpregnant and early postpartum women. Pregnancy was statistically significantly less likely to be associated with positive PE on a CTPA study. The common perception that pregnancy (antepartum state) is associated with an increased risk of PE may require a thorough critical reappraisal.
Steatohepatitis due to FOLFIRINOX regimen in adjuvant pancreas cancer treatment mimicking liver metastasis
Authors: Bozkurt Duman Berna , Çil Timuçin 
Published: February 2020

Introduction The combination of fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) is more toxic than gemcitabine, but it is a safe regimen with manageable toxicities. Case report We report a case with steatohepatitis mimicking liver metastasis as toxicity that was not seen in study patient population. Management and outcome: In the adjuvant statement with FOLFIRINOX due to biopsy, we give the same regimen by excluding metastasis. Discussion The adverse events of drugs are important predictive factor for treatment management, as important as efficacy. Especially the new lesion and metastasis is the most important factor for changing treatment. The clinicians must be careful about adverse events of regimens. Conclusion FOLFIRINOX regimen is the most important combination in pancreas cancer adjuvant setting. This case shows us the different presentation of usual adverse event.