bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical update on managing media exposure and misinformation during COVID-19: recommendations for governments and healthcare professionals
Authors: Looi Jeffrey CL , Allison Stephen , Bastiampillai Tarun , Maguire Paul A 
Published: October 2020

Objectives: To provide a clinical update on the mechanisms of, and potential population mental health risks of, excessive media exposure and misinformation regarding the COVID-19 pandemic. To outline guidance for government, health services, psychiatrists and health professionals in managing mental health effects of COVID-19 media exposure. Conclusions: Social and traditional media businesses attract interest by reporting threats and negativity, and heavy media exposure during disasters is associated with increased depressive and post-traumatic symptoms. There are three main recommendations for mitigation of the adverse population mental health effects of excessive media exposure and misinformation. Clear, authoritative communication from governments, health authorities and health professionals is essential, combined with correction of misinformation and addressing mistrust. Specific warnings by governments, health authorities and clinicians of the potential adverse mental health consequences of excessive COVID-19 media consumption are needed. Limitation of exposure to media and disinformation regarding COVID-19 is crucial – the less, the better. Healthcare professionals can advise patients to check information once daily, and be guided by reliable public health authorities, as part of interventions for managing the mental health impact of COVID-19.
A Feasibility Study of a Volunteer Navigation Program in the Palliative Context
Authors: Duggleby Wendy , Pesut Barbara , Warner Grace , Ruiz Kathya Jovel , Nekolaichuk Cheryl , Ghosh Sunita , Hallström Lars , Fassbender Konrad , Swindle Jenny , Holroyd-Leduc Jayna , Jackman Deirdre , Woytkiw Terri 
Published: October 2020

Older persons with serious illnesses living in rural communities are an underserved population. They often live with heavy symptom burden and poor quality of life with limited access to resources. Nav-CARE (Navigation: Connecting Accessing Resourcing and Engaging) was developed to specially train and mentor volunteer navigators who help connect older persons with serious illness to the resources and information they need. Aims: This mixed methods longitudinal study evaluated Nav-CARE for feasibility, acceptability, ease of use, and satisfaction by older persons and volunteers. Methods: Nine volunteer navigators visited 23 older persons with serious illness every 3 to 4 weeks for 1 year. Data were collected from volunteer navigators, and older person participants at baseline, during the year- long implementation and post implementation. Results: Volunteer navigators and older persons reported Nav-CARE was easy to use, feasible and acceptable. The majority of older persons agreed or strongly agreed that they were satisfied with the navigation services (100%; 8/8), that navigation services were important to them (87%; 7/8), that they would recommend the program to someone else (87%; 7/8), and would participate in the program again (75%; 6/8). Similarly, volunteer navigators reported 100% (9/9) satisfaction with the program, 100% (9/9) would recommend it to others, and 67% (6/8) would participate again. Conclusions: Nav-CARE appears to be a feasible, acceptable, and satisfactory program for older persons with serious illness and volunteer navigators.
Comparative morphometry of the temporomandibular joint in brachycephalic and mesocephalic cats using multislice CT and cone beam CT
Authors: Delesalle Quentin , Lopes António M , Gawor Jerzy P , Zani Davide , Pereira Hugo M , Mestrinho Lisa A 
Published: October 2020

Objectives The purpose of this study was to analyse and compare morphometric measurements of the temporomandibular joint (TMJ) in two groups of cats with brachycephalic and mesocephalic craniofacial skull conformations using multislice CT and cone beam CT. Methods CT records of 20 cats without TMJ pathology were included in the study, and were divided into two groups according to those with mesocephalic or brachycephalic skull conformation. Width and depth of the mandibular fossa, width and height of the head of the mandible, and two different angles were measured in 40 TMJs. Results TMJ conformation differed between groups: 3/6 parameters were statistically different. Brachycephalic cats had a significantly narrower mandibular fossa, a shorter head of the mandible and a wider angle of congruence (angle 2). Conclusions and relevance The results provide morphometric measurements that can serve as a reference tool for the veterinary radiologist and surgeon when TMJ evaluation is necessary. Moreover, the study identified significant differences between the two craniofacial skull conformations.
HDMTX-based polychemotherapy including intraventricular therapy in elderly patients with primary CNS lymphoma: a single center series
Authors: Seidel Sabine , Kowalski Thomas , Margold Michelle , Baraniskin Alexander , Schroers Roland , Martus Peter , Schlegel Uwe 
Published: October 2020

Background: To investigate outcome and toxicity of high-dose systemic methotrexate (HDMTX)-based polychemotherapy and intracerebroventricular (ICV) chemotherapy via an Ommaya reservoir in elderly patients with primary central nervous system lymphoma (PCNSL). Methods: We performed a retrospective analysis on patients ⩾65 years with first diagnosis of PCNSL admitted to our center between January 2015 and December 2019. These patients were treated with a standardized chemotherapy protocol in case of absent contraindications for HDMTX-based chemotherapy. The protocol contained induction therapy with systemic rituximab, methotrexate and ifosfamide and consolidation treatment with systemic cytarabine (AraC) and ICV methotrexate, prednisolone and AraC. Results: Of a total of 46 patients seen in this period, 3 did not qualify for HDMTX. Thus, 43 patients were included in this analysis. Median age was 74 years (range 65–86), median Karnofsky performance score was 50 (range 20–90). Of the 43 patients, 32 (74.4%) completed treatment including ICV therapy. Complete remission/complete remission unconfirmed was achieved in 26 of 43 patients (60.5%), partial response (PR) in 3 (7%); 5 (11.6%) had progressive disease, and 3 (7.0%) died due to treatment-related complications; in the remaining 6 (14.0%) therapy could not be completed. Median progression free survival was 16 months (95% confidence interval 8–24 months) and median overall survival had not been reached after a median follow up of 23 months (range 1–52 months); the 75th percentile survival time was 12 months. No Ommaya reservoir infection was observed. Complications of ICV treatment were pericatheter leucencephalopathy in two patients and surgical scar dehiscence with cerebrospinal fluid leak in one patient. Conclusion: Toxicity of HDMTX plus ICV chemotherapy for elderly patients with PCNSL was manageable and outcome was excellent for patients treated with this protocol.
Influence of the Medial Malleolus Osteotomy on the Clinical Outcome of M-BMS + I/III Collagen Scaffold in Medial Talar Osteochondral Lesion (German Cartilage Register/Knorpelregister DGOU)
Authors: Gottschalk Oliver , Baumbach Sebastian Felix , Altenberger Sebastian , Körner Daniel , Aurich Matthias , Plaass Christian , Ettinger Sarah , Guenther Daniel , Becher Christoph , Hörterer Hubert , Walther Markus 
Published: October 2020

Objective Osteochondral lesions of the talus are common injuries, with one of the leading treatment options being the M-BMS (matrix-augmented bone marrow stimulation) + I/III collagen scaffold. Osteotomy of the medial malleolus is not unusual but presents the risk of malunion or irritation by hardware. The aim of the study was to analyze data from the German Cartilage Society (Knorpelregister DGOU) to evaluate the influence of medial malleolar osteotomy on clinical results of M-BMS + I/III collagen scaffold. Design The ankle module of the Cartilage Register includes a total of 718 patients, while 45 patients met the inclusion criteria. Patients were treated with an M-BMS + I/III collagen scaffold of the medial talus, 30 without and 15 with an osteotomy of the medial malleolus. The follow-up evaluations included FAAM (Foot and Ankle Ability Measure), FAOS (Foot and Ankle Outcome Score), and VAS (visual analogue scale). Results Forty-five patients (22 male, 23 female) aged between 18 and 69 years (mean: 34 years) were included in this study. Between preoperative and 12 months postoperative, we noted a significant improvement in FAAM-ADL (Activity of Daily Living) ( P = 0.004) as well as FAOS-Pain ( P = 0.001), FAOS-Stiffness ( P = 0.047), FAOS-ADL ( P = 0.002), FAOS-Sport ( P = 0.001), and FAOS Quality of Life ( P = 0.009). There was no significant difference between patients who underwent an osteotomy or not. Conclusion The results show a significant improvement in patients’ outcome scores following a M-BMS + I/III collagen scaffold. No statistical difference was noted among those undergoing medial malleolar osteotomy.
A training program for fibromyalgia management: A 5-year pilot study
Authors: Bodéré Céline , Cabon Mathilde , Woda Alain , Giroux-Metges Marie-Agnès , Bodéré Youenn , Saliou Philippe , Quinio Bertrand , Misery Laurent , Le Fur-Bonnabesse Anais 
Published: October 2020

We studied the effects of a specific cardio training program lasting 5 years on pain and quality of life in fibromyalgia patients. Method: An observational longitudinal pilot study was conducted in 138 fibromyalgia women. Fibromyalgia women recruited were asked to carry out three sessions per week, each lasting 45 min, of moderate-intensity continuous training (64%–75% Maximal Heart rate [HRmax]). During the first year, the patients progressively increased their training intensity. During the last 2 years, the patients were asked to associate moderate-intensity continuous training and high-intensity interval training (85%–90% HRmax). Pain on a visual analog scale, anxiety and depression state on the Hospital Anxiety and Depression Scale, impact of fibromyalgia on daily life using the Fibromyalgia Impact Questionnaire, heart rate and sleep quality (visual analog scale) were assessed at baseline and each year for 5 years. Results: Forty-nine patients dropped out in the first year. Depending on their training status, the remaining 89 patients were retrospectively assigned to one of the three groups: Active (moderate-intensity continuous training), Semi-Active (one or two sessions, low-intensity continuous training <60% HRmax) and Passive (non-completion of training), based on their ability to comply with the program. Alleviation of all symptoms ( p < 0.0001) was observed in the Active group. Increasing exercise intensity enhanced the effects obtained with moderate-intensity continuous training. Significant change in the Fibromyalgia Impact Questionnaire ( p < 0.0001) and depression (Hospital Anxiety and Depression Scale; p < 0.0001), and no significant decrease in pain were noted in the Semi-Active group. No effect of the training was observed in the Passive group. Conclusion: The study intervention associated with multidisciplinary care alleviated pain, anxiety and depression, and improved both quality of life and quality of sleep, in fibromyalgia patients.
Thrombocytopenia in 737 adult intensive care unit patients: A real-world study of associated factors, drugs, platelet transfusion, and clinical outcome
Authors: Zhang Man-ka , Xu Tian-qi , Zhang Xiao-jing , Rao Zhi-guo , He Xiao-xu , Wu Mei-qing , Li Zhou-ping , Liu Yin , Yang Jing-cheng , Gong Yi-fan , Tang Ming , Xue Xiao-yan 
Published: October 2020

Objective: We aimed to identify and represent factors associated with thrombocytopenia in intensive care unit, especially the pathogens and drugs related to severe and extremely thrombocytopenia. Then, we aim to compare the mortality of platelet transfusion and non-transfusion in patients with different degrees of thrombocytopenia. Methods: We identified all thrombocytopenic patients in intensive care unit by using platelet-specific values and then extracted electronic health records from our Hospital Information System. Data were statistically analyzed with t test, chi-square test, and logistic regression. Results: We found that infections (32.7%) were the most frequent cause associated with thrombocytopenia, followed by sepsis shock (3.93%) and blood loss (2.99%). Meanwhile, antifungals ( p = 0.002) and bacterial infection ( p = 0.037) were associated with severe and extremely severe thrombocytopenia. Finally, we found that the mortality of platelet transfusion and non-transfusion in patients was statistically significant for patients with platelet counts between 30 and 49/nL (χ2 = 9.719, p = 0.002). Conclusion: Infection and sepsis emerged as two primary factors associated with thrombocytopenia in intensive care unit. Meanwhile, antifungals and bacterial infection were associated with platelet counts less than 49/nL. Finally, platelet transfusion may be associated with reduced mortality in patients with platelet counts between 30 and 49/nL.
Graft Function, Albuminuria, and the Risk of Hemorrhage and Thrombosis After Kidney Transplantation
Authors: Jeong Rachel , Quinn Robert R. , Ravani Pietro , Ye Feng , Sood Manish M. , Massicotte-Azarniouch David , Tonelli Marcello , Hemmelgarn Brenda R. , Lam Ngan N. 
Published: October 2020

Background: Compared to the general population, kidney transplant recipients are at increased risk of hemorrhage and thrombosis. Whether this risk is affected by graft function and albuminuria is unknown. Objective: To determine the association between graft function and albuminuria and the risk of post-transplant hemorrhage and thrombosis. Design: Retrospective cohort study. Setting: We used linked health care databases in Alberta, Canada. Patients/sample/participants: We included adult kidney transplant recipients from 2002 to 2015 with a functioning graft at 1 year. Measurements: Estimated glomerular filtration rate (eGFR) and albuminuria measurements at 1 year post-transplant were used to categorize recipients (eGFR: ≥45 vs. <45 mL/min/1.73 m2; albuminuria: absence vs. presence). We determined the rates of post-transplant hemorrhage and venous thrombosis based on validated diagnostic and procedural codes. Methods: We determined the association between categories of eGFR and albuminuria and post-transplant hemorrhage and venous thrombosis using Poisson regression with log link. Results: Of 1284 kidney transplant recipients, 21% had an eGFR <45 mL/min/1.73 m2 and 40% had presence of albuminuria at 1 year post-transplant. Over a median follow-up of 6 years, there were 100 hemorrhages (12.6 events per 1000 person-years) and 57 venous thrombosis events (7.1 events per 1000 person-years). The age- and sex-adjusted rate of hemorrhage and thrombosis was over 2-fold higher in recipients with lower eGFR and presence of albuminuria compared to higher eGFR and no albuminuria (hemorrhage: incidence rate ratio, IRR, 2.6, 95% confidence interval [CI]: 1.5-4.4, P = .001; thrombosis: IRR, 2.3, 95% CI: 1.1-5.0, P = .046). Limitations: Complete relevant medication information, such as anticoagulants, were not available in our datasets. Due to sample size, this study was underpowered to conduct a fully adjusted analysis. Conclusion: Among kidney transplant recipients, lower eGFR and presence of albuminuria at 1 year post-transplant were associated with an over 2-fold higher risk of hemorrhage and venous thrombosis. Graft function and albuminuria at 1 year post-transplant are important prognostic factors in determining risk of post-transplant hemorrhage and venous thrombosis. Further research, including medication data, are needed to further delineate outcomes and safety. Trial registration: Not applicable (cohort study).
Importance of early treatment decisions on future income of multiple sclerosis patients
Authors: Kavaliunas Andrius , Manouchehrinia Ali , Gyllensten Hanna , Alexanderson Kristina , Hillert Jan 
Published: October 2020

Background Early initiation of disease-modifying treatment (DMT) is associated with better disability outcomes in multiple sclerosis (MS). However, little is known of how treatment decisions affect socio-economic outcomes. Objective To estimate the long-term impact of early initiation of DMT on the income of MS patients. Methods In total, 3610 MS patients were included in this register-based cohort study. We measured the association between the time to treatment and the outcome, defined as time from treatment initiation to a 95% decrease in annual earnings compared to each patient´s baseline level. Additionally, the association between time to treatment and increase of social benefits (sickness absence, disability pension) was investigated. A Cox model was adjusted for sex, onset age, education, family situation, country of birth, living area, and disability. Results MS patients initiating treatment later had a higher risk of reaching the outcome- those who started treatment after 2 years from MS onset lost 95% of their earnings sooner (HR, 1.19; 95% CI, 1.04–1.37). Furthermore, risk to receive an annual compensation of SEK 100,000 (≈EUR 10,500) was higher for the delayed treatment group. Conclusion Early treatment initiation in MS is associated with better socioeconomic outcome, adding to previous studies showing benefits regarding disability.
Axicabtagene ciloleucel for relapsed or refractory lymphoma after prior treatment with a different CD19-directed CAR T-cell therapy
Authors: Chow Victor A. , Gopal Ajay K. , Gauthier Jordan , Tseng Yolanda D. , Turtle Cameron J. , Maloney David G. , Shadman Mazyar 
Published: October 2020

Key Points
No meaningful responses were observed when axicabtagene ciloleucel was used for progression after a different CD19-directed CAR T cell. Further research is needed to understand how to sequence cell-based therapies for relapsed/refractory large B-cell lymphomas.
Successful transfer of anti–SARS-CoV-2 immunity using convalescent plasma in an MM patient with hypogammaglobulinemia and COVID-19
Authors: Luetkens Tim , Metcalf Ryan , Planelles Vicente , Zheng Yue , Larragoite Erin T. , Spivak Emily S. , Spivak Adam M. , Steinbach Mary , Blaylock Robert C. , Avila Stephanie V. , Hankey Kim G. , Martins Thomas B. , Slev Patricia R. , Mannuel Heather D. , Sajadi Mohammad , Rapoport Aaron P. , Atanackovic Djordje 
Published: October 2020

Key Points
A severely immunocompromised patient with MM and COVID19 who received a convalescent plasma product showed SARS-CoV-2 clearance. The convalescent plasma showed humoral immunity against all structural SARS-CoV-2 proteins, which was successfully transferred to the patient.
Two cases of penile strangulation: varied presentations and vastly different outcomes
Authors: Agrawal Mayank , Gite Venkat Arjun , Sankapal Prakash 
Published: October 2020

Abstract
Background
Penile strangulation by various metallic and non-metallic objects is a true urological emergency that requires prompt emergency management. The cases in this report will help in highlighting the varied presentations one can face in the emergency department. Management of such cases at times needs out-of-the-box thinking and improvised skills as resources to remove the foreign body are often scarce within the hospital.

Case presentation
We present two such cases of penile strangulation in adult patients. Both patients presented to us in the emergency department, one with a large metallic cone and another with a rubber band constricting their penises. Both the patients had hugely different grades of injuries and were managed accordingly. Both the patients required different methods to remove the constriction objects as per the need of the situation. One of the patients required total penectomy with permanent perineal urethrostomy; however, in the other case, we were able to save the penis.

Conclusion
Penile strangulation needs urgent medical attention and timely removal of the offending object. Grade of injuries and complications are directly proportional to the type of object and the duration of the strangulation. The non-metallic objects are easy to cut and remove. However, one should be aware of the challenges and the complications in managing metallic foreign bodies which at times may need out-of-the-box thinking, like use of motorized cutting tools.
Patterns of household and personal care product use by the Korean population: implications for aggregate human exposure and health risk
Authors: Han Eun Jeong , Choi KeunOh , Sim Seunghye , Choi Junyeong , Uhm Yoonhee , Kim Soonbok , Lim Eunkyung , Lee YoungJoo 
Published: October 2020

Abstract
Background
Household and personal care products (H&PCPs) are used frequently in the domestic environment. Different types of H&PCPs often contain the same chemicals and have potential for aggregate exposure. Therefore, product use patterns should be investigated to assess exposure and health risk.

Results
A nationwide survey was conducted in Korea to examine the use of 16 types of H&PCPs, to obtain data that can be used for such assessments. The initial analysis focused on identifying usage patterns, such as the frequency of use and amount of product used per application. Then, co-use in 16 product categories were analyzed. Family size, marital status and age were, respectively, recognized as the critical demographic factor for classification of the frequency of use in laundry products, cleaning products and shower products. In laundry products, cleaning products and shower products, frequent H&PCPs co-use patterns according to demographical factor were recognized. Chances of exposure of chemical ingredients to participants were investigated based on the usage of individual products. 32 chemicals among all investigated ingredients were identified to be potentially exposed to more than half of the participants, and 21 chemicals are classified above Class 4 in acute toxicity.

Conclusions
Personal preference was not observed both in the use frequency and the amount per application of H&PCPs, among all participants. Instead, household duties were found to be associated with the yearly use frequency of household care products. In addition, the yearly chemical profiles of individual consumer were obtained, and the chemicals that have multiple chances of exposure and concomitant health risk in daily life were identified. The results provide the overview of distribution of chemicals in daily life, and essential ground for aggregate exposure assessment in Korea.