bluuebunny/crossref_metadata_2025_split huggingface dataset:
CORRELATED BEHAVIOR IN LIMIT ORDER CANCELLATIONS, COMOVEMENT IN ASSET RETURNS, AND COMMONALITY IN LIQUIDITY
Authors: Egginton Jared , Watson Ethan D. 
Published: November 2019

AbstractWe examine whether there is common behavior in limit order cancellation activity, that is, commonality in cancellation activity, on U.S. exchanges. We then examine whether this commonality in cancellation activity is associated with increased levels of return comovement and commonality in liquidity. We document strong evidence of limit order traders exhibiting exchange, industry, marketwide, and stock‐level commonality with regard to cancellation activity, which is consistent with limit order traders exhibiting correlated trading behavior. We also find that this correlated behavior in cancellation activity is associated with increased levels of return comovement and commonality in liquidity.
Distraction using virtual reality for children during intravenous injections in an emergency department: A randomised trial
Authors: Chen Yen‐Ju , Cheng Su‐Fen , Lee Pi‐Chang , Lai Chi‐Hsiu , Hou I‐Ching , Chen Chi‐Wen 
Published: November 2019

AbstractAim and objectivesTo determine whether the virtual reality as a distracting intervention could reduce pain and fear in school‐age children receiving intravenous injections at an emergency department.BackgroundAn intravenous injection is the most common invasive procedure that paediatric patients encounter in emergency department. School‐age children seldom show their fear or discomfort during the procedure which may be ignored.DesignA randomised controlled trial was conducted from December 2017–May 2018 and performed according to the CONSORT guidelines.MethodsOne hundred and thirty‐six children aged 7–12 years were randomly allocated to receive either a routine intravenous injection procedure or one with an immersive virtual reality experience. Children were asked to rate their pain and fear along with their caregivers and nurses on the Wong–Baker FACES Pain Rating Scale and Children's Fear Scale, respectively. The time required for successful intravenous insertion was also assessed in the emergency department. Clinical trial registration was done (ClinicalTrials.gov.: NCT04081935).ResultsPain and fear scores were significantly lower in the virtual reality group, as were the children's ratings as perceived by their caregivers and nurses. The children's ratings of pain and fear were positively correlated with the caregivers’ ratings and the nurses' ratings as well. The time required for successful intravenous insertion was significantly lower in the virtual reality group.ConclusionVisual reality intervention can effectively reduce the pain and fear during intravenous procedure in school‐age children in emergency department.Relevance to clinical practiceThe results of this study indicate the feasible clinical value of virtual reality interventions during the administration of intravenous injections in school‐age children in emergency departments.
Nurses' evidence‐based practice knowledge, attitudes and implementation: A cross‐sectional study
Authors: Alqahtani Naji , Oh Kyeung M. , Kitsantas Panagiota , Rodan Margaret 
Published: November 2019

AbstractAim and ObjectivesTo examine the influence of staff nurses’ individual factors on knowledge, attitudes and implementation of evidence‐based practice in Saudi Arabia and to identify facilitators and barriers to evidence‐based practice implementation.BackgroundEvidence‐based practice has been considered as a key for healthcare quality measure. The literature, however, shows that nurses worldwide are not implementing evidence‐based practice as expected and recommended by governing agencies. In Saudi Arabia, evidence‐based practice implementation has not been addressed sufficiently.DesignA cross‐sectional, correlational design was used. We have complied with the guidelines of STROBE Checklist in presenting this research. A convenience sample of staff nurses (n = 227) was selected from four hospitals in Riyadh, Saudi Arabia. The survey questions included the Evidence‐based Practice Questionnaire and individual factors. Data were analysed using multiple linear regression models.ResultsAttitudes towards evidence‐based practice had the highest mean followed by evidence‐based practice knowledge and implementation means. Evidence‐based practice training and research involvement were associated with knowledge in the bivariate and multivariate analyses. None of the individual factors were associated with attitudes. However, knowledge was associated with attitudes. Knowledge and attitudes influenced evidence‐based practice implementation positively. Unexpectedly, receiving evidence‐based practice training made it more difficult for nurses to participate in evidence‐based practice implementation process. We found that attitudes partially mediated the relationship between knowledge and evidence‐based practice implementation.ConclusionNurses in Saudi Arabia are willing to be involved in the evidence‐based practice process. However, nurses identified that they need to improve their knowledge and skills in order to be active participants in the process.Relevance to clinical practiceOrganisations and nursing leadership may benefit from developing a comprehensive strategy to promote staff nurses’ involvement in the evidence‐based practice process through providing continuing education and mentoring programmes about evidence‐based practice.
Development of an on-line Raman spectral analytical method for monitoring and endpoint determination of the Cornu Caprae Hircus hydrolysis process
Authors: Yan Xu , Li Wenlong , Zhang Xiaoli , Liu Shaoyong , Qu Haibin 
Published: November 2019

Abstract

Objectives
Cornu Caprae Hircus (goat horn, GH), a medicinal animal horn, is frequently used in traditional Chinese medicine, and hydrolysis is one of the most important processes for GH pretreatment in pharmaceutical manufacturing. In this study, on-line Raman spectroscopy was applied to monitor the GH hydrolysis process by the development of partial least squares (PLS) calibration models for different groups of amino acids.

Methods
Three steps were considered in model development. In the first step, design of experiments (DOE)-based preprocessing method selection was conducted. In the second step, the optimal spectral co-addition number was determined. In the third step, sample selection or reconstruction methods based on hierarchical clustering analysis (HCA) were used to extract or reconstruct representative calibration sets from the pool of hydrolysis process samples and investigated for their ability to improve model performance.

Key findings
This study has shown the feasibility of using on-line Raman spectral analysis for monitoring the GH hydrolysis process based on the designed measurement system and appropriate model development steps.

Conclusions
The proposed Raman-based calibration models are expected to be used in GH hydrolysis process monitoring, leading to more rapid material information acquisition, deeper process understanding, more accurate endpoint determination and thus better product quality consistency.
Effects of IGFBP-3 and GalNAc-T14 on proliferation and cell cycle of glioblastoma cells and its mechanism
Authors: Yang Jiao , Hu Yuhua , Wu Jianliang , Kong Shiqi 
Published: November 2019

Abstract

Objective
The purpose of this study was to determine the effects of IGFBP-3 and GalNAc-T14 on the proliferation and cell cycle of glioblastoma cells and to explore the mechanisms of action.

Methods
U87MG and U251MG glioblastoma cells were treated with recombinant human IGFBP-3 (rhIGFBP-3). Furthermore, IGFBP-3-overexpressed cells and cells co-overexpressing IGFBP-3 and GalNAc-T14 were constructed by transfection. Cell viability, cell colony formation ability, cell cycle and protein expression were determined by MTT assay, colony formation assay, flow cytometry and Western blotting, respectively.

Key findings
Both rhIGFBP-3 treatment and overexpression of IGFBP-3 induced the proliferation, colony formation, and G1/S phase transformation of U87MG and U251MG cells. In addition, the expression of cyclinE, CDK2 and p-ERK1/2 proteins was up-regulated in the cells. In cells co-overexpressing, IGFBP-3 and GalNAc-T14, cell proliferation, colony formation and G1/S phase transformation were inhibited, and the expression of CyclinE, CDK2 and p-ERK1/2 was significantly down-regulated, when compared with IGFBP-3-overexpressed cells.

Conclusions
IGFBP-3 can promote the proliferation, colony formation and G1/S phase transformation of U87MG and U251MG cells, which may be related to the activation of ERK signalling pathway and the up-regulation of cyclinE and CDK2 proteins. Furthermore, our study demonstrated that GalNAc-T14 can inhibit the functions of IGFBP-3.
A botanical drug composed of three herbal materials attenuates the sensorimotor gating deficit and cognitive impairment induced by MK-801 in mice
Authors: Koo Bokyung , Bae Ho Jung , Goo Nayeon , Kim Jaehoon , Kim Jihyun , Cai Mudan , Jung In Ho , Cho Kyungnam , Jung Seo Yun , Chang Suk Woo , Jang Dae Sik , Ryu Jong Hoon 
Published: November 2019

Abstract

Objectives
A botanical drug derived from the ethanolic extract composed of Clematis chinensis Osbeck (Ranunculaceae), Trichosanthes kirilowii Maximowicz (Cucurbitaceae) and Prunella vulgaris Linné (Lamiaceae) has been used to ameliorate rheumatoid arthritis as an ethical drug in Korea. In our study, we investigated the effect of this herbal complex extract (HCE) on schizophrenia-like behaviours induced by MK-801.

Methods
HCE (30, 100 or 300 mg/kg, p.o) was orally administered to male ICR mice to a schizophrenia-like animal model induced by MK-801. We conducted an acoustic startle response task, an open-field task, a novel object recognition task and a social novelty preference task.

Key findings
We found that a single administration of HCE (100 or 300 mg/kg) ameliorated MK-801-induced abnormal behaviours including sensorimotor gating deficits and social or object recognition memory deficits. In addition, MK-801-induced increases in phosphorylated Akt and GSK-3β expression levels in the prefrontal cortex were reversed by HCE (30, 100 or 300 mg/kg).

Conclusions
These results imply that HCE ameliorates MK-801-induced dysfunctions in prepulse inhibition, social interactions and cognitive function, partly by regulating the Akt and GSK-3β signalling pathways.
Semistatic and sparse variance‐optimal hedging
Authors: Di Tella Paolo , Haubold Martin , Keller‐Ressel Martin 
Published: November 2019

AbstractWe consider the problem of hedging a contingent claim with a “semistatic” strategy composed of a dynamic position in one asset and static (buy‐and‐hold) positions in other assets. We give general representations of the optimal strategy and the hedging error under the criterion of variance optimality and provide tractable formulas using Fourier integration in case of the Heston model. We also consider the problem of optimally selecting a sparse semistatic hedging strategy, i.e., a strategy that only uses a small subset of available hedging assets and discuss parallels to the variable‐selection problem in linear regression. The methods developed are illustrated in an extended numerical example where we compute a sparse semistatic hedge for a variance swap using European options as static hedging assets.
Inter‐facility transfers for advanced critical care services: Impacts on rural families
Authors: Burns Margie , Petrucka Pammla 
Published: November 2019

AbstractAims and ObjectivesThe aim of this article is to provide an integrative review of rural family members' experiences of a relative's inter‐facility transfer to an urban tertiary care centre for advanced critical care services.BackgroundAlthough there is an increasing awareness of the negative consequences of a relative's critical illness for family members, there has been limited research conducted on the impacts of this experience for families of patients in rural settings who require an inter‐facility transfer for advanced services.Search strategyThe search strategy for this review was framed by the study purpose, research question, and a conceptual structure of key constructs. Databases and reference lists were electronically and manually searched.Inclusion and exclusion criteriaArticles were included if they were research articles, available in English, and focused on family members' experiences of inter‐facility transfer during critical illness. Articles focusing on critical care transfers within a single urban setting, elective transfers undertaken for patient or family preference, transfers not associated with critical illness, and systematic or scoping reviews were excluded.ConclusionStress and anxiety are central to the rural family members' experience of this phenomenon. These constructs are influenced by modifiable factors, including the actions of health care providers, the financial burden associated with the transfer, the family members' physical proximity to the patient, and their access to information and support networks. Further research is required to explore potential short‐ and long‐term consequences of this experience and the experience of family members who are left behind and to develop and test interventions to support families.Relevance to clinical practiceThis review highlights the concern that health care providers frequently misunderstand the needs of family members who are experiencing this phenomenon. Through a better understanding of this phenomenon, health care providers will be better positioned to effectively support these individuals during this unique experience.
Comparative spatial lipidomics analysis reveals cellular lipid remodelling in different developmental zones of barley roots in response to salinity
Authors: Sarabia Lenin D. , Boughton Berin A. , Rupasinghe Thusitha , Callahan Damien L. , Hill Camilla B. , Roessner Ute 
Published: November 2019

AbstractSalinity‐induced metabolic, ionic, and transcript modifications in plants have routinely been studied using whole plant tissues, which do not provide information on spatial tissue responses. The aim of this study was to assess the changes in the lipid profiles in a spatial manner and to quantify the changes in the elemental composition in roots of seedlings of four barley cultivars before and after a short‐term salt stress. We used a combination of liquid chromatography–tandem mass spectrometry, inductively coupled plasma mass spectrometry, matrix‐assisted laser desorption/ionization mass spectrometry imaging, and reverse transcription – quantitative real time polymerase chain reaction platforms to examine the molecular signatures of lipids, ions, and transcripts in three anatomically different seminal root tissues before and after salt stress. We found significant changes to the levels of major lipid classes including a decrease in the levels of lysoglycerophospholipids, ceramides, and hexosylceramides and an increase in the levels of glycerophospholipids, hydroxylated ceramides, and hexosylceramides. Our results revealed that modifications to lipid and transcript profiles in plant roots in response to a short‐term salt stress may involve recycling of major lipid species, such as phosphatidylcholine, via resynthesis from glycerophosphocholine.
A NAC‐type transcription factor confers aluminium resistance by regulating cell wall‐associated receptor kinase 1 and cell wall pectin
Authors: Lou He Qiang , Fan Wei , Jin Jian Feng , Xu Jia Meng , Chen Wei Wei , Yang Jian Li , Zheng Shao Jian 
Published: November 2019

AbstractTranscriptional regulation is important for plants to respond to toxic effects of aluminium (Al). However, our current knowledge to these events is confined to a few transcription factors. Here, we functionally characterized a rice bean (Vigna umbellata) NAC‐type transcription factor, VuNAR1, in terms of Al stress response. We demonstrated that rice bean VuNAR1 is a nuclear‐localized transcriptional activator, whose expression was specifically upregulated by Al in roots but not in shoot. VuNAR1 overexpressing Arabidopsis plants exhibit improved Al resistance via Al exclusion. However, VuNAR1‐mediated Al exclusion is independent of the function of known Al‐resistant genes. Comparative transcriptomic analysis revealed that VuNAR1 specifically regulates the expression of genes associated with protein phosphorylation and cell wall modification in Arabidopsis. Transient expression assay demonstrated the direct transcriptional activation of cell wall‐associated receptor kinase 1 (WAK1) by VuNAR1. Moreover, yeast one‐hybrid assays and MEME motif searches identified a new VuNAR1‐specific binding motif in the promoter of WAK1. Compared with wild‐type Arabidopsis plants, VuNAR1 overexpressing plants have higher WAK1 expression and less pectin content. Taken together, our results suggest that VuNAR1 regulates Al resistance by regulating cell wall pectin metabolism via directly binding to the promoter of WAK1 and induce its expression.
Functional evaluation of the various calculation methods for precompression stress
Authors: De Pue Jan , Di Emidio Gemmina , Bezuijen Adam , Cornelis Wim M. 
Published: November 2019

AbstractPrecompression stress (σp) is commonly used as an indicator for the load carrying capacity of a soil and its stress history. Several calculation methods have been proposed to determine σp, but they have proven to be not interchangeable. The aim of this study was to perform a functional evaluation of seven existing methods to test which method would be most recommended to assess soil strength in cultivated fields. This was achieved by investigating the relation of the obtained σp of undisturbed soil samples to other soil properties and stress history. Additionally, the robustness of the methods was evaluated by checking their sensitivity to perturbation of the measured strains. The two most commonly used methods, the Casagrande method and Gompertz model fit method, were found to be the least suitable to calculate σp. These methods lack robustness and do not yield a significant relation with the relevant soil properties or stress history. Better results were obtained with Intersecting linear regressions or at the inflection point of a fourth‐degree polynomial.
Maternal sepsis update: current management and controversies
Authors: Greer Orene , Shah Nishel Mohan , Johnson Mark R 
Published: November 2019

Key content

Sepsis is a leading cause of maternal morbidity and mortality, globally and in the UK.

In pregnancy and the puerperium, women may be more susceptible to rapid deterioration of illness following an infection.

Sepsis has a complex pathophysiology and the immunological and cardiovascular adaptations of normal pregnancy may have an adverse impact on the maternal response to infection. Furthermore, physiological changes of pregnancy, which mimic those of sepsis, often delay recognition and optimal management.

‘Bedside’ identification of pathogens and their antibiotic resistance patterns may help to improve clinical outcomes.

Recent updates in sepsis management, areas of controversy and the importance of translational research and clinical trials for pregnancy and the puerperium are discussed.

Learning objectives

To highlight the difficulties of diagnosing sepsis in pregnancy.

To highlight recent updates, new definitions and controversies of current sepsis management.

To highlight the potential for research to develop novel biomarkers and therapeutic agents specific to the pregnant woman.

Ethical issues

Sepsis research involving new technologies differentially benefits high‐income countries compared with low‐/middle‐income countries despite the greatest burden of maternal sepsis being in the latter.

With the current rapid evolution of omic technology platforms, greater affordability will provide greater accessibility.
PEATmoss (Physcomitrella Expression Atlas Tool): a unified gene expression atlas for the model plant Physcomitrella patens
Authors: Fernandez‐Pozo Noe , Haas Fabian B. , Meyberg Rabea , Ullrich Kristian K. , Hiss Manuel , Perroud Pierre‐François , Hanke Sebastian , Kratz Viktor , Powell Adrian F. , Vesty Eleanor F. , Daum Christopher G. , Zane Matthew , Lipzen Anna , Sreedasyam Avinash , Grimwood Jane , Coates Juliet C. , Barry Kerrie , Schmutz Jeremy , Mueller Lukas A. , Rensing Stefan A. 
Published: November 2019

SummaryPhyscomitrella patens is a bryophyte model plant that is often used to study plant evolution and development. Its resources are of great importance for comparative genomics and evo‐devo approaches. However, expression data from Physcomitrella patens were so far generated using different gene annotation versions and three different platforms: CombiMatrix and NimbleGen expression microarrays and RNA sequencing. The currently available P. patens expression data are distributed across three tools with different visualization methods to access the data. Here, we introduce an interactive expression atlas, Physcomitrella Expression Atlas Tool (PEATmoss), that unifies publicly available expression data for P. patens and provides multiple visualization methods to query the data in a single web‐based tool. Moreover, PEATmoss includes 35 expression experiments not previously available in any other expression atlas. To facilitate gene expression queries across different gene annotation versions, and to access P. patens annotations and related resources, a lookup database and web tool linked to PEATmoss was implemented. PEATmoss can be accessed at https://peatmoss.online.uni-marburg.de
Association between perceived psychological stress and cognitive decline in aging: a systematic review protocol
Authors: de Souza-Talarico Juliana Nery , Benavente Sonia Betzabeth Ticona , Alves Andrea Regiani , de Motta Maia Flávia Oliveira , Costa Ana Lúcia Siqueira 
Published: November 2019

Review question/objective
: The objective of this review is to identify, appraise and synthesize the best available evidence on the association between perceived psychological stress and cognitive decline in aging.
Modeling of 3D Rock Porous Media by Combining X-Ray CT and Markov Chain Monte Carlo
Authors: Lin Wei , Li Xizhe , Yang Zhengming , Xiong Shengchun , Luo Yutian , Zhao Xinli 
Published: November 2019

Abstract
Rocks contain multi-scale pore structures, with dimensions ranging from nano- to sample-scale, the inherent tradeoff between imaging resolution and sample size limits the simultaneous characterization of macro-pores and micro-pores using single-resolution imaging. Here, we developed a new hybrid digital rock modeling approach to cope with this open challenge. We first used micron-CT to construct the 3D macro-pore digital rock of tight sandstone, then performed high-resolution SEM on the three orthogonal surfaces of sandstone sample, thus reconstructed the 3D micro-pore digital rock by Markov chain Monte Carlo (MCMC) method; finally, we superimposed the macro-pore and micro-pore digital rocks to achieve the integrated digital rock. Maximal ball algorithm was used to extract pore-network parameters of digital rocks, and numerical simulations were completed with Lattice-Boltzmann method (LBM). The results indicate that the integrated digital rock has anisotropy and good connectivity comparable with the real rock, and porosity, pore-throat parameters and intrinsic permeability from simulations agree well with the values acquired from experiments. In addition, the proposed approach improves the accuracy and scale of digital rock modeling and can deal with heterogeneous porous media with multi-scale pore-throat system.