bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tolcapone Treatment for Cognitive and Behavioral Symptoms in Behavioral Variant Frontotemporal Dementia: A Placebo-Controlled Crossover Study
Authors: Fremont Rachel , Manoochehri Masood , Armstrong Nicole M. , Mattay Venkata S. , Apud Jose A. , Tierney Mary C. , Devanand D.P. , Gazes Yunglin , Habeck Christian , Wassermann Eric M. , Grafman Jordan , Huey Edward D. 
Published: May 2020

Background: There are currently no disease-targeted treatments for cognitive or behavioral symptoms in patients with behavioral variant frontotemporal dementia (bvFTD). Objective: To determine the effect of tolcapone, a specific inhibitor of Catechol-O-Methyltransferase (COMT), in patients with bvFTD. Methods: In this randomized, double-blind, placebo-controlled, cross-over study at two study sites, we examined the effect of tolcapone on 28 adult outpatients with bvFTD. The primary outcome was reaction time on the N-back cognitive test. As an imaging outcome, we examined differences in the resting blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) signal intensity between subjects on placebo versus tolcapone performing the N-back test. Secondary outcomes included measures of cognitive performance and behavioral disturbance using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), Neuropsychiatric Inventory-Questionnaire (NPI-Q), and Clinical Global Impressions scale (CGI). Results: Tolcapone was well tolerated and no patients dropped out. The most frequent treatment-related adverse event during tolcapone treatment was elevated liver enzymes (21%). There were no significant differences between tolcapone treatment and placebo in the primary or imaging outcomes. However, there were significant differences between RBANS total scores ( p < 0.01), NPI-Q total scores ( p = 0.04), and CGI total scores ( p = 0.035) between treatment conditions which were driven by differences between baseline and tolcapone conditions. Further, there was a trend toward significance between tolcapone and placebo on the CGI ( p = 0.078). Conclusions: Further study of COMT inhibition and related approaches with longer duration of treatment and larger sample sizes in frontotemporal lobar degeneration-spectrum disorders may be warranted.
Treat-to-Target urate-lowering therapy in primary gout patients: A real-world retrospective study at a dedicated gout clinic in China
Authors: Bai Xue-Shan , Wang Ming , Zhao Xiao-Dong , Cui Ling-Ling , He Yu-Wei , Wang Can , Li Xin-De , Qu Xiao-Jie , Sun Ming-Shu , Li Chang-Gui 
Published: May 2020

BACKGROUND: Gout is the most common inflammatory arthritis affecting 1.1% of the population in mainland China with a higher prevalence in coastal areas. OBJECTIVE: The purpose of the study was to investigate the clinical outcomes following urate-lowering therapy (ULT) in a real-world group study of primary gout patients in China. METHODS: Electronic medical records of all the gout patients (n= 1588) that visited the Clinical Medical Center of Gout of the Affiliated Hospital of Qingdao University from September 2016 to February 2018 were analyzed in this study. The patients were treated with a standard treat-to-target (T2T) ULT strategy according to the 2016 EULAR Guidelines. Clinical data were collected in the first visit and one-month (defined as the baseline of ULT), 7-month, and 13-month follow-ups were completed. RESULTS: Amongst the patients in the study, 92.70% accepted ULT and 82.93% completed ULT for 3 months, 63.54% for 6 months, and 40.49% (n= 643) for 12 months. Further analysis of the 643 patients included the following data: the sUA level reduced at month 7 and reduced further at month 13. The gout flares, patient global pain visual analogue score, and health assessment questionnaire score improved at month 7 but did not improve further at month 13, and the index tophus size did not
Linguistic Data Model for Natural Languages and Artificial Intelligence. Part 4. Language
Authors: Polyakov O. M. 
Published: May 2020

Introduction. The paper continues a series of publications on linguistics of relations (hereinafter R–linguistics) and is devoted to questions of the formation of a language from a linguistic model of the world. Moreover, the language is considered in its most general form, without taking into account the grammatical component. This allows you to focus on the general problems of language formation. Namely, this allows us to show why language adequately reflects the model of the world and what are the features of the transition from model to language. This new approach to language is relevant in connection with the formation of an understanding of the common core in all natural languages, as well as in connection with the needs for the formation of artificial intelligence subsystems of interaction with humans.Methodology and sources. Research methods consist in the formulation and proof of theorems about language spaces and their properties. The materials of the paper and the given proofs are based on the previously stated ideas about linguistic spaces and their decompositions into signs.Results and discussion. The paper shows how, in the most general form, the formation of language structures takes place. Namely, why does language adequately reflect the linguistic model, and what is the difference between linguistic and language spaces? The concepts of an open and closed form of the language are formulated, as well as the law of form. Examples of open and closed forms of the language are shown. It is shown that the formation of the language allows you to compensate for the lack of real signs in the surrounding world while maintaining the prognostic properties of the model.Conclusion. Any natural language is a reflection of the human world model. Moreover, all natural languages are similar in terms of the principles of forming the core of the language (language space). Language spaces standardize the models of the world by equalizing real and fictional signs of categories. In addition, the transition to language simplifies some of the problems of pattern recognition and opens the way to the logic of natural language.
The Concept “Semantic Invariant" as a Cognitive Term
Authors: Pesina S. A. 
Published: May 2020

Introduction. The purpose of the paper is to prove the semantic integrity of the meanings of polysemous words based on the use of the concepts “semantic network“ and “lexical invariant“. The relevance of this study lies in the lack of sufficient support of semantic integrity of lexemes, since there are contradictory linguistic data in favor of the so-called list theory of word representation in the mental lexicon. We put forward the hypothesis of network structuring of word meanings based on the “lexical invariant“, understood as a set of dominant basic semantic components, which underlie contextual meanings in one of their configurations. We pointed out the characteristic features and advantages of the network model of polysemous words as an open system capable of building an unlimited number of connections. The study is also concerned with the determination of the way the meanings are mapped in the semantic space of the lexicon by means of revealing the content of the semantic structures of the polysemous words.Methodology and sources. The paper presents an empirical invariant-component method of analyzing a polysemous word “key“.Results and discussion. The main results of the study indicate that there are numerous interconnected semantic networks of polysemous words in the lexicon. They function as multi-level configurations of meanings, which are cemented by dominant invariant meanings. Invariant meanings are eventually formed as a result of multiple use of all metaphorical meanings clusters, which allow native speakers to effectively navigate in the surrounding language environment.Conclusion. The results of our study have proved the idea that native speakers do not need detailed information (numerous semantic components) to interpret this or that meaning. The number of components they use in everyday communication is limited but sufficient for general understanding of the words and texts contents. The research results enabled us to draw a conclusion that in order to preserve the semantic integrity of a word structure, the number of meanings must remain within the limits of the invariant semantic components. The invariant lexical components form clusters of integral and differential types that combined in different configurations form a word desired meaning.
A Study of Chinese Piano Works from the Perspective of Ethnomusicology
Authors: Bi Huan 
Published: May 2020

Chinese piano works are closely related to folk music. In piano education, Chinese piano works should be analyzed from the perspective of ethnomusicology to guide the students to accurately understand and feel the characteristics and charm of national music culture. This paper probes into the unique national cultural characteristics, national musical styles and musical aesthetic characteristics of Chinese piano works.
Peran Public Relations Dalam Membangun Reputasi Perguruan Tinggi
Authors: Yulista Yera 
Published: May 2020

The development of higher education institutions in Indonesia indicates the increasing meaning of education in the community so that the existence of educational institutions becomes the target for stakeholders, especially students / prospective students. In general, to maintain the existing stakeholders clearly requires the establishment of a good reputation in the community. One of the parties that can help higher education institutions in building the reputation of higher education is the presence of public relations. PR represents the institution in implementing the communication program to be a bridge between the organizations represented by the university stakeholders.
Abstrak
Perkembangan lembaga pendidikan tinggi di Indonesia menandakan semakin meningkatnya arti pendidikan di tengah masyarakat sehingga keberadaan lembaga pendidikan menjadi incaran bagi stakehoder khususnya mahasiswa/ calon mahasiswa. Secara umum untuk mempertahankan stakeholder yang ada jelas memerlukan pembentukan reputasi yang baik ditengah masyarakat.Salah satu pihak yang dapat membantu lembaga pendidikan tinggi dalam membangun reputasi perguruan tinggi adalah dengan kehadiran public relations. PR mewakili lembaga dalam melaksanakan program komunikasi untuk menjadi jembatan penghubung antara organisasi yang diwakili dengan stakeholder perguruan tinggi.
Revisión: Genes de radio resistencia en cáncer cérvico-uterino localmente avanzado
Authors: Vallín Delgado Eder , Alatriste Martínez Sara , Rosas Cabral Alejandro 
Published: May 2020

La radioterapia constituye la piedra angular del tratamiento del cáncer cérvico-uterino (CaCu) avanzado. Actualmente, el consenso mundial del tratamiento estándar, de las etapas localmente avanzadas de esta neoplasia, es la asociación de radioterapia concomitante con la quimioterapia basada en platino. Se ha demostrado que la expresión de algunos genes dentro de las poblaciones celulares del CaCu contribuye a la falta de respuesta al tratamiento con quimio-radioterapia, en pacientes con similares factores de riesgo al momento del diagnóstico. A este grupo de genes se les ha denominado genes de radio-resistencia o quimio-resistencia. Dentro de estos genes destacan los relacionados con la promoción del crecimiento celular indiferenciado, el escape a los puntos de restricción del ciclo celular y los relacionados con alteraciones de la apoptosis. Los genes que mayor interés han despertado hasta el momento como potenciales marcadores de radio-resistencia son: Bcl-2, Lgals, iASPP, Np73, XCRR5, HIF-1α, IGF1, IGF-1R, Bak LDHA, y EIF4A1. Sin embargo, dentro de estos mecanismos también interfieren otros genes capaces de generar radio-sensibilidad como los son el RBP1 y el ALDH1. Este último, particularmente, es capaz de generar quimio-resistencia. En el presente trabajo realizamos una revisión de la evidencia disponible hasta el momento en la literatura, para conocer los mecanismos a través de los cuales actúan estos genes y cómo los mismos pudieran ser marcadores que ayuden a planear una correcta estrategia terapéutica y, de esta manera, mejorar el pronóstico de las pacientes con CaCu.
Palabras clave: Cáncer cervico-uterino, radioterapia, radio-resistencia, XCRR5, HIF-1α, IGF1, IGF-1R, Bak, LDHA, EIF4A1, RBP1, ALDH1
The Prehospital Ambulance Stroke Test Vs. The Cincinnati Prehospital Stroke Scale: A Diagnostic Accuracy Study
Authors: Karimi Somayeh , Motamed Hassan , Aliniagerdroudbari Ehsan , Babaniamansour Sepideh , Jami Arman , Baratloo Alireza 
Published: May 2020

Introduction Immediate diagnosis of stroke is crucial in reducing its morbidity and mortality rate. There are various pre-hospital assessment tools, such as the Prehospital Ambulance Stroke Test (PreHAST) and the Cincinnati Prehospital Stroke Scale (CPSS) used to identify stroke early in the chain of care. The aim of this study is to compare the accuracy of PreHAST with CPSS in diagnosing stroke. Methods In this diagnostic accuracy study patients with suspicion of stroke were included in this study. In CPSS, the criterion used to indicate stroke are facial droop, speech and arm drift. In PreHAST it is eye position, visual field, facial palsy, right and left arms paresis, right and left legs paresis, sensory and speech. After data collection, sensitivity and specificity were calculated using standard formulae. Different cut-off points for the best diagnostic accuracy were examined in both CPSS and PreHAST. Results In this study, 883 patients were investigated. The results demonstrated that in CPSS, the highest specificity and sensitivity was for facial droop (84.9%) and arm drift (82.7%); and in PreHAST it was eye position (99.6%) and facial palsy (49.2%). The best predictor of stroke in CPSS with highest sensitivity (78.5%) and specificity (66%) was a cut-off point of 1.5 (AUC: 0.744) (p<0.01(. In PreHAST, the highest sensitivity (68.4%) was a cut-off point of 2.5 and the highest specificity (90.2%) was a cut-off point of 5.5 (AUC: 0.775) (p<0.01). Conclusion Both PreHAST and CPSS are useful screening tools in the pre-hospital diagnosis of stroke. In addition to high sensitivity, these tests provide a grading system in which higher cut-off points lead to higher specificity.
Coronavirus e ambiente: una sfida per il pianeta e per la salute
Authors: Magnaghi Cristiano , Brioni Elena , Leopaldi Donato , Pegoraro Marisa , Vezzoli Giuseppe , Manunta Paolo , Parisotto Maria Teresa 
Published: May 2020

In late December 2019, some patients were hospitalized with an initial diagnosis of pneumonia of unknown etiology. These patients were epidemiologically linked to a wholesale market of seafood, wild animals and meat located in Wuhan, Hubei province, China. Acute respiratory disease caused by a new Coronavirus SARS-CoV-2, formerly known as 2019-nCoV, afterwards as Coronavirus disease 2019 (COVID-19), spread throughout China and received the attention of the entire world. Analysis of the genomic sequence of COVID-19 showed 88% of identity with two bat-derived severe acute respiratory syndrome-like Coronaviruses. Illegal and sustainable wildlife trade is the second largest direct threat to species after habitat destruction. Each year, hundreds of millions of plants and animals are captured or collected in the wild to be sold as food, pets, medicines, ornaments and for a variety of other reasons. Even the climate crisis could offer dangerous scenarios in addition to another fundamental chapter of the environmental pillar which is the one concerning air quality. There is a solid scientific literature which correlates the incidence of viral infection cases with concentrations of atmospheric particulate matter (e.g. PM10 and PM2.5). Despite the current regulations, which limit the levels of certain atmospheric pollutants, there are still numerous negative health effects deriving from exposure to these agents. However, it can be said that chronic air pollution, such as peaks of concentration of fine dust and other pollutants, acts as a pejorative factor in cases of epidemics. (GCND_planet)
Peran Penting Lembaga Pangan dan Generasi Milenial di Era Industri 4.0 dalam Mendukung Ketahanan Pangan Nasional
Authors: Utomo Bachtiar 
Published: May 2020

Kebijakan pangan di Indonesia tidak dapat dilepaskan dari peran Perum BULOG sebagai lembaga pangan pemerintah. Pengelolaan pangan nasional saat ini menghadapi permasalahan, diantaranya penggunaan teknologi pertanian yang masih sederhana, kondisi sumber daya manusia di bidang pertanian yang masih terbatas, alih fungsi lahan pertanian serta keterbatasan infrastruktur dan sarana penunjang, serta rendahnya sinergitas sektor hulu dan hilir yang menyebabkan pengelolaan pertanian menjadi kurang efektif, efisien, dan ekonomis. Makalah ini bertujuan untuk (i) menganalisis permasalahan dalam pengelolaan pangan di Indonesia; (ii) menelaah peran dan upaya Perum BULOG sebagai lembaga pangan Pemerintah; serta (iii) menelaah peran generasi milenial dalam mendukung ketahanan pangan nasional di era industri 4.0. Hasil analisis menunjukkan bahwa permasalahan di sektor pertanian yang harus dihadapi dan diatasi, yaitu pengelolaan on farm dan off farm yang masih minim teknologi; kuantitas dan kualitas SDM yang masih rendah; permasalahan distribusi yang membebani cost structure untuk setiap produk; alih fungsi lahan; keterbatasan infrastruktur, suprastruktur, dan fasilitas yang masih belum memadai; serta integrasi dari hulu ke hilir yang masih belum terjalin dengan baik. Kebijakan pangan yang diterapkan oleh Pemerintah perlu dipandang secara menyeluruh lintas kementerian/lembaga dan tidak dipandang secara sektoral. Peran generasi milenial dalam pengembangan sektor pertanian di era revolusi industri 4.0 menuntut SDM yang paham untuk mengoperasikan sistem teknologi informasi yang canggih yang serba digital. Untuk itu peran generasi milenial diharapkan menjadi penggerak industri pertanian 4.0 karena generasi milenial dianggap fasih dalam mengadopsi teknologi digital yang canggih dan memiliki kreativitas untuk mengembangkan berbagai inovasi dibidang pertanian melalui aplikasi teknologi digital.
Marked improvement in reliability of 150 °C processed IGZO thin-film transistors by applying hydrogenated IGZO as a channel material
Authors: Koretomo Daichi , Hamada Shuhei , Mori Marin , Magari Yusaku , Furuta Mamoru 
Published: May 2020

Abstract
A marked improvement in the reliability of a high-mobility In–Ga–Zn–O (IGZO) thin-film transistor (TFT) is presented after 150 °C annealing by applying hydrogenated IGZO (IGZO:H) as a channel. To enhance field-effect mobility (μ
FE), the atomic ratio of In:Ga:Zn was chosen to be 6:2:1. The IGZO:H TFT exhibited a μ
FE of 18.9 cm2 V−1 s−1 without hysteresis. Moreover, the reliability of the IGZO:H TFT significantly improved after 150 °C annealing as compared with that of a conventional IGZO TFT. Thus, the use of IGZO:H is an effective method of improving both the electrical properties and reliability of TFTs for flexible electronics.
Faktor Risiko Air Bone Gap Pada Otitis Media Supuratif Kronik
Authors: Inardi Yoke Kurniawan , Widodo Pujo , Naftali Zulfikar , Yusmawan Willy 
Published: May 2020

Latar belakang : Kehilangan pendengaran merupakan komplikasi otitis media kronik (OMSK) yang paling sering, jenis kehilangan pendengaran yang tersering adalah tuli konduktif, yang disebabkan oleh adanya air bone gap (ABG), ABG pada pasien OMSK mempunyai variasi yang berbeda-beda dan karakter yang khas berdasarkan faktor risiko.
Tujuan : Menganalisis hubungan faktor risiko dengan ABG pada penderita OMSK.
Metode : Penelitian desain observational analitik retrospektif di RSUP Dr Kariadi Semarang pada bulan September 2018 - Januari 2019. Data diambil dari rekam medis. jumlah sampel ditentukan sebanyak 100. Analisis data dengan uji chi-square.
Hasil : Jenis kelamin laki-laki 46 orang, wanita 54 orang, rerata usia 32 tahun. Status osikula, lama sakit, kolesteatom, luas perforasi membran telinga berhubungan terhadap ABG (p <0,05).
Kesimpulan : Faktor risiko (status osikula, lama sakit, kolesteatom, perforasi membran timpani) berhubungan dengan air bone gap pada penderita OMSK.
Kata kunci : Air bone gap, faktor risiko, otitis media supuratif kronik.

Background: Hearing loss is the most frequent complication of chronic otitis media (CSOM), hearing loss is usually caused by conductive deafness caused by the presence of an air bone gap (ABG). ABG in CSOM patients has different variations and distinctive characters based on the factors.
Objective: To analyze the relationship of risk factors ABG in CSOM patients.
Methods: Observational analytic study with a retrospective observational analytic design at Dr. Kariadi Hospital Semarang in September 2018 - January 2019. Subjects were 100 patients. Data retrieval is done based on medical records about history taking, physical examination and investigation. Data were analyzed by Chi-square test.
Results: A total male 46 and female. Avarage age 32 years. Oscular status, duration of illness, cholesteatom, area of ??ear membrane perforation associated with ABG (p <0.05).
Conclusion: Risk factors (osicular status, duration of illness, cholesteatom, tympanic membrane perforation) associated with air bone gap in CSOM patients.
Keywords: Chronic supurative otitis media, air bone gap, risk factors
Serial Case : Unilateral Dan Trilateral Retinoblastoma
Authors: HIsbulloh Hisbulloh , Hendara Farah 
Published: May 2020

LATAR BELAKANG
Retinoblastoma adalah tumor intraocular pada anak. Insidensi diperkirakan 1 dalam 15.000 pada 34.000 kelahiran. Retinoblastoma trilateral merupakan kombinasi yang jarang dari unilateral atau bilateral retinoblastoma dengan neoplasma intrakranial neuroblastik, biasanya ditemukan di daerah pineal atau daerah suprasellar. Dalam kasus retinoblastoma trilateral , prognosisnya buruk dengan tingkat kelangsugan hidup antara 9 sampai 13 bulan setelah diagnosis.
LAPORAN KASUS
Kasus 1, anak laki-laki berusia 1 tahun dengan keluhan leukokoria mata kanan, proptosis, kemerahan, kelopak mata bengkak dan juga memiliki riwayat perdarahan di mata kanan. Pemeriksaan CT scan menunjukkan lesi padat dengan kalsifikasi pada aspek posterior mata kiri (AP 1,32 x LL 1,72 x CC 0,7 cm). Kontras CT mata kanan menunjukkan massa jaringan lunak dengan kalsifikasi (AP 3,57 x LL 3,1 x CC 3,1 cm), meluas ke retrobulbar, saraf optik menebal dan massa parasellar yang enhance(AP 2,6 x LL 2,5 x CC 2,2 cm)
Kasus 2, anak laki-laki berusia 2 tahun dengan keluhan mata kanan tampak plak putih yang semakin melebar. Pada pemeriksaan CT scan menunjukan lesi pada inhomogen irregular disertai kalsifikasi pada intra bulbus occuli kanan.

PEMBAHASAN
Retinoblastoma bisa terjadi baik unilateral bilateral, trilateral maupun quadrilateral. Pada kasus ini, pemeriksaan radiologi berperan untuk mendeteksi adanya tumor baik intra ocular maupun ekstra ocular. Diagnosis yang cepat dan tepat dengan menggunakan neuroimaging disertai penatalaksanaan yang agresif dapat menurunkan mortalitas pada pasien dengan retinoblastoma dan tumor intracranial.
KESIMPULAN
Diagnosis awal dan pengobatan terbukti penting dalam mengatasi perluasan tumor dan metastasis intracranial yang kemungkinan menyebabkan kematian. CT scan dan MRI sangat penting untuk diagnosis awal, perluasan, staging, rencana pengobatan dan follow up pasien retinoblastoma.
Kata kunci : retinoblastoma, unilateral, trilateral, CT scan