bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ephemeris Refinement of the Exoplanet Candidate around the White Dwarf WD1856+534
Authors: Mallonn Matthias 
Published: December 2020

Abstract
The exoplanet candidate around the white dwarf WD 1856+534 is of special interest for exoplanet atmosphere characterization because of its very cool temperature and potentially large spectral signal in transmission spectroscopy. Here we present ground-based transit follow-up to verify the transit depth and refine the orbital ephemeris allowing for a more accurate scheduling of future transit observations. Our new ephemeris provides transit time predictions with an uncertainty of less than 30 s until the year 2030.
SIVIM Deciduous Forests – Database of deciduous forests from the Iberian Peninsula
Authors: Campos Juan Antonio , Mercadé Arnau , Font Xavier 
Published: December 2020

“SIVIM Deciduous Forests” is a thematic database established in 2015, focused on forest vegetation from the Iberian Peninsula and southern France. It was registered in the Global Index of Vegetation Databases (GIVD ID: EU-00-023) in January 2016. All types of temperate and submediterranean non-riparian deciduous forests of the phytosociological classes Carpino-Fagetea sylvaticae, Quercetea pubescentis and Quercetea robori-petraeae (formerly combined in the class Querco-Fagetea) are represented in the database. Currently, it contains 6,642 published vegetation plots of beech, birch, ash, lime and other deciduous mixed forests, as well as forests dominated by different species of deciduous and marcescent oaks, 100% of them classified at association level. Data are stored in TURBOVEG format, and are available upon request from the international vegetation-plot databases EVA and sPlot in semi-restricted regime. The relevés have also been included in SIVIM database, and thus they are freely available online. However, in SIVIM Deciduous Forests geolocation accuracy has been improved and the taxonomy and syntaxonomy unified. Plot size is available for 73% of the relevés, of which 82% are between 100 and 400 m2. Plant taxonomy is standardized to Flora iberica. During the last four years, data of SIVIM Deciduous Forests were requested via EVA and sPlot for different projects, and have been used for several studies with various objectives, from floristic, vegetation and habitat-related topics to macroecological studies, and from local to global scales.
Abbreviations: EVA = European Vegetation Archive; GIVD = Global Index of Vegetation-Plot Databases; SIVIM = Iberian and Macaronesian Vegetation Information System.
Encontros e (des)encontros entre a Educação Física e a creche: análises sobre ações do Pibid
Authors: Heydt Heinen Eduarda , Eger de Souza Marcos Aurélio , Silva José Ricardo 
Published: December 2020

O presente texto é um estudo de revisão do tipo estado da arte que busca na produção acadêmica relatos de experiências que contemplem ações da Educação Física aliada ao Programa Institucional de Bolsas de Iniciação à Docência (Pibid) na creche. Para tanto, alocamos a investigação na faixa temporal que compreende o início do PIBID, 2007 até o ano de 2019. Como banco de dados, optou-se pelas seguintes plataformas on line Scientific Electronic Library Online (SciELO), Literatura Latina-Americana e do Caribe em Ciências da Saúde (LILACS) e o Catálogo de teses e dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). O resultado demonstra escassa produção sobre o tema derivado de um histórico (des)encontro entre a Educação Física e a Educação Infantil e, consequentemente do edital do Pibid. Com o intuito de contribuir com o debate, relatamos nossa experiência de encontro entre a Educação Física e o Pibid na creche. Em nossas conclusões, defendemos a atuação do professor de Educação Física na creche desde que em consonância com as concepções de desenvolvimento integral e o Pibid enquanto política pública de formação inicial e continuada de docentes como forma de superar concepções pragmáticas e mecânicas de atuação deste profissional na Educação Infantil.
ANGKA KEJAHATAN DAN REAKSI SISTEM PERADILAN PIDANA DI MASA PANDEMI COVID-19
Authors: Harkrisnowo Harkristuti 
Published: December 2020

Masa pandemi yang datang tiba-tiba telah menyebabkan disrupsi luar biasa pada kehidupan manusia di seluruh dunia. Tulisan ini mencoba membahas dampaknya pada kejahatan yang terjadi, baik dari angka maupun sebarannya. Dengan menggunakan data dari media dan laporan lembaga resmi, akan didiskusikan dampak pandemi pada jenis, frekuensi, durasi dan sebaran kejahatan. Analisis terhadap data kejahatan menunjukkan bahwa tidak dapat ditentukan adanya trend yang pasti tentang ada tidaknya terjadi kenaikan atau penurunan angka kejahatan secara konstan. Sejumlah variabel yang diduga memiliki korelasi dengan angka kejahatan adalah karakteristik wilayah, demografi, serta ketegasan dan konsistensi dalam pelaksanaan kebijakan. Kondisi luar biasa ini dihadapi oleh sistem peradilan pidana yang juga tidak mungkin menjalankan fungsinya dengan business as usual. Terobosan-terobosan yang diambil oleh lembaga penanggung jawab sistem peradilan pidana untuk menghadapi permasalahan ini juga akan dibahas.
Rights and Wrongs in Scholarly Understanding of the Topic of North Africa and the Holocaust
Authors: Michman Dan 
Published: December 2020

Abstract
The Holocaust and its impact are by now a vast interdisciplinary field of research that is carried out across the globe. Recently, growing attention has been paid to the fate of North African Jewry during the Holocaust period. The volume under review, based on papers from a 2015 conference on this subject at UCLA, raises some essential questions regarding the history and present state of research in this field. The review closely and critically examines the various chapters, which from the perspective of scholarly quality range from excellent to frustrating. This article elaborates on essential issues from the perspective of the broader field of Holocaust historiography: conceptualization of “the Holocaust” and what is part of it and what is not; the evolution of Holocaust historiography in general and as relating to North Africa; and knowledge by scholars in this field of the broader picture of the Holocaust, especially the evolution of anti-Jewish policies. The conclusion is that research has to be done with an awareness of the multifacetedness of the Holocaust and without simplistic generalizations and trivializations.
Når skolens børn evaluerer sig selv
Authors: Berg Mathias Sune , Kaas Lise Aagaard , Grumløse Sine Penthin 
Published: December 2020

I overensstemmelse med ideen om livslang læring forventes skolebørn i stigende grad at vurdere, hvad de har lært. Karakteristisk for disse selvevalueringspraksisser er, at de ikke kun knytter sig til børnenes faglige kompetencer. De går ofte også tæt på børnenes mere personlige forhold. Derudover er evaluering en del af den skolepolitiske dagsorden, hvor læreren er forpligtet på at dokumentere elevernes læring.
I denne artikel går vi tæt på undervisningen og præsenterer eksempler på evalueringspraksisser, der skaber vidt forskellige deltagelsesmuligheder for børnene. Der er fokus på aktiviteter, hvor børnene skal vurdere, hvad de har lært, gennem brug af evalueringsværktøjer som portfolio og læringsplatforme. Vi diskuterer den udspændthed, som læreren befinder sig i mellem på den ene side at efterleve politiske krav om evaluering og på den anden side at praktisere evaluering, der kan udvikle undervisningen og styrke børnenes trivsel og læring samtidig med hensynet til børnenes behov og forudsætninger.
Educación crítica de las artes visuales en estudiantes de diseño gráfico. Relaciones de aprendizaje en torno a la cultura visual
Authors: Delgado Hishochy , Torres Yasselle Angela , Alonso Maylín 
Published: December 2020

La dimensión crítica en los procesos de enseñanza y aprendizaje universitarios constituye un estadio superior del intelecto y la moral en los educadores y educando. Encuentra su base teórica, epistemológica y metodológica en las capacidades reconstructivas y autónomas del sujeto libre que piensa y crea. En esta investigación pretendemos abordar –desde las experiencias como docentes e investigadores- el andamiaje contextual que sitúa al discurso crítico como una necesidad educativa en estudiantes de Diseño Gráfico. Realizaremos un análisis de los componentes curriculares que intervienen en las decisiones para conformar un aparato crítico hacia el objeto artístico visual y responder a la pregunta ¿qué sentido tienen la educación crítica y su discurso sobre Artes Visuales en estudiantes de Diseño Gráfico? Para ello, proponemos repensar las nociones de crítica, en contextos diversos por los que transita la cultura visual en aras de una educación más compleja, a través de relatos que cuentan las intimidades de las artes visuales.
Més enllà de l’escalfament global: Oceans estressats globalment a l’antropocè
Authors: Pelejero Carles , Calvo Eva 
Published: December 2020

La petjada de les activitats humanes sobre el planeta és tan profunda que molts científics ja suggereixen que hem entrat en una nova època geològica, l’antropocè. D’entre aquestes activitats, les que venen acompanyades de grans emissions de diòxid de carboni (CO2) afecten d’una manera global tot el planeta i, sobretot, els oceans. Aquests, a banda d’escalfar-se, es tornen progressivament més àcids i menys oxigenats. En aquest article discutim l’abast d’aquests estressos globals sobre els oceans després de contextualitzar aquest desorbitat augment antropogènic de CO2 i de veure com es distribueix. Acabem amb una discussió sobre possibilitats de mitigació a través dels oceans mateixos, tot recalcant la necessitat imperiosa i urgent d’atacar el problema, sobretot durant aquesta dècada que hem començat.
Policy Brief: Ending Open Defecation in Nigeria
Authors: Okuku Mary Obidiya 
Published: December 2020

The purpose of this paper is to present a policy brief on ending open defecation in Nigeria. The briefing notes the burden of open defecation (OD) in Nigeria, its causes, the impact of OD practices, successes achieved so far, as well as the failures encountered and offers recommendations to end the practice in order to achieve the sustainable development goal (SDG) 6.2 of ending open defecation globally by 2030 as proposed by the United Nations.
Key Recommendations:

Strong Political Will to uphold and implement policies on sanitation
Building more latrines
Establishing monitoring team
Capacity building
Sustainable job creation
Improved communication strategy
Platelet‐derived extracellular vesicles are increased in sera of Alzheimer's disease patients, as revealed by Tim4‐based assays
Authors: Odaka Haruki , Hiemori Keiko , Shimoda Asako , Akiyoshi Kazunari , Tateno Hiroaki 
Published: December 2020

Alzheimer's disease (AD) is the most common form of dementia, characterized by the accumulation of β‐amyloid plaques and the formation of neurofibrillary tangles. Extracellular vesicles (EVs) are small vesicles surrounded by a lipid bilayer membrane, which may be involved in the progression of AD. Glycans are essential building blocks of EVs, and we hypothesized that EV glycans may reflect pathological conditions of various diseases. Here, we performed glycan profiling of EVs prepared from sera of three AD patients (APs) compared to three healthy donors (HDs) using lectin microarray. Distinct glycan profiles were observed. Mannose‐binding lectins exhibited significantly higher signals for AP‐derived EVs than HD‐derived EVs. Lectin blotting using mannose‐binding lectin (rPALa) showed a single protein band at ~ 80 kDa exclusively in AP‐derived EVs. LC‐MS/MS analysis identified a protein band precipitated by rPALa as CD61, a marker of platelet‐derived exosomes (P‐Exo). Sandwich assays using Tim4 with specificity for phosphatidylserine on EVs and antibodies against P‐Exo markers (CD61, CD41, CD63, and CD9) revealed that P‐Exo is significantly elevated in sera of APs (n = 16) relative to age‐ and sex‐matched HDs (n = 16). Tim4‐αCD63 showed the highest value for the area under the curve (0.957) for discriminating APs from HDs, which should lead to a better understanding of AD pathology and may facilitate the development of a novel diagnostic method for AD.
Potent Trivalent Inhibitors of Thrombin through Hybridization of Salivary Sulfopeptides from Hematophagous Arthropods
Authors: Agten Stijn M. , Watson Emma E. , Ripoll‐Rozada Jorge , Dowman Luke J. , Wu Mike C. L. , Alwis Imala , Jackson Shaun P. , Pereira Pedro José Barbosa , Payne Richard J. 
Published: December 2020

AbstractBlood feeding arthropods, such as leeches, ticks, flies and mosquitoes, provide a privileged source of peptidic anticoagulant molecules. These primarily operate through inhibition of the central coagulation protease thrombin by binding to the active site and either exosite I or exosite II. Herein, we describe the rational design of a novel class of trivalent thrombin inhibitors that simultaneously block both exosites as well as the active site. These engineered hybrids were synthesized using tandem diselenide‐selenoester ligation (DSL) and native chemical ligation (NCL) reactions in one‐pot. The most potent trivalent inhibitors possessed femtomolar inhibition constants against α‐thrombin and were selective over related coagulation proteases. A lead hybrid inhibitor possessed potent anticoagulant activity, blockade of both thrombin generation and platelet aggregation in vitro and efficacy in a murine thrombosis model at 1 mg kg−1. The rational engineering approach described here lays the foundation for the development of potent and selective inhibitors for a range of other enzymatic targets that possess multiple sites for the disruption of protein–protein interactions, in addition to an active site.
Programme and school predictors of mentoring relationship quality and the role of mentors' satisfaction in volunteer retention
Authors: Aresi Giovanni , Pozzi Maura , Marta Elena 
Published: December 2020

AbstractThe quality of the mentor–mentee relationship is considered the key mechanism of change in mentoring programmes, and volunteer mentor retention is crucial to improving delivery and outcomes. Combining theoretical frameworks on mentoring programmes and volunteerism, this study aimed to examine: (a) programme and school predictors of mentoring relationship closeness and (b) the relations between mentor‐reported relationship closeness, satisfaction with the relationship as a measure of subjective evaluations of their work and expressed intention to continue mentoring in the future. Volunteer mentors (N = 103, mean age = 65 years, 75% female) from a school‐based mentoring programme in Italy completed a survey. Results of path analyses revealed that relationship closeness was associated in a positive manner with perceptions of the adequacy of the mentoring session setting, and programme support, but not teacher support. In addition, mentors' satisfaction partially mediated the connection between relationship closeness and intention to remain in the programme. Implications for practice are discussed. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
Relapsed plasmablastic lymphoma in a HIV‐negative patient: Pushing the envelope
Authors: Kathrotiya Manthan , Radhakrishnan Vivek S , Bhave Saurabh J , Kumar Jeevan , Roychowdhury Mita , Arun Indu , Das Jayanta , Chandy Mammen , Nair Reena 
Published: December 2020

AbstractThis case emphasizes that, with the availability of novel immunotherapy agents (Daratumumab), and repurposed use of bortezomib, a patient with HIV‐negative relapsed PBL can be treated successfully and consolidated with an allogeneic haploidentical hematopoietic cell transplantation.
Patterns of richness across forest beetle communities—A methodological comparison of observed and estimated species numbers
Authors: Haack Nora , Grimm‐Seyfarth Annegret , Schlegel Martin , Wirth Christian , Bernhard Detlef , Brunk Ingo , Henle Klaus 
Published: December 2020

Abstract

Species richness is a frequently used measure of biodiversity. The compilation of a complete species list is an often unattainable goal. Estimators of species richness have been developed to overcome this problem. While the use of these estimators is becoming increasingly popular, working with the observed number of species is still common practice.

To assess whether patterns of beetle communities based on observed numbers may be compared among each other, we compared patterns from observed and estimated numbers of species for beetle communities in the canopy of the Leipzig floodplain forest. These patterns were species richness and the number of shared species among three tree species and two canopy strata.

We tested the applicability of the asymptotic Chao1 estimator and the estimate provided by the nonasymptotic rarefaction–extrapolation method for all tree species and both upper canopy and lower canopy. In the majority of cases, the ranking patterns of species richness for host tree species and strata were the same for the observed and estimated number of species. The ranking patterns of the number of species shared among host tree species and strata, however, were significantly different between observed and estimated values.

Our results indicate that the observed number of species under‐represents species richness and the number of shared species. However, ranking comparisons of published patterns based on the number of observed species may be acceptable for species richness but likely not reliable for the number of shared species. Further studies are needed to corroborate this conclusion. We encourage to use estimators and to provide open access to data to allow comparative assessments.
Placement of edge server based on task overhead in mobile edge computing environment
Authors: Li Bo , Hou Peng , Wu Hao , Qian Rongrong , Ding Hongwei 
Published: December 2020

SummaryMobile edge computing (MEC) deployed cloud computing resources (such as storage and computing power) to the edge of wireless access networks to better meet the development of 5G communication and computing‐intensive applications. As the first step of MEC architecture deployment, the placement of the edge server (ES) is the foundation and key, and its location affects the user experience and system performance. In this article, we study the placement of ESs in the heterogeneous networks and express it as an optimization problem. Weighing the response delay and energy consumption as the task overhead, and place the ESs on the optimal access point (AP). An adaptive clustering algorithm MTO based on AP suitability evaluation is proposed to solve the optimal solution, which minimizes the task overhead of computing tasks. Extensive experimental simulations evaluate the performance of the algorithm, and the results show that the MTO algorithm is superior to other representative methods.
Neutrophils and Visceral Leishmaniasis: Impact on innate immune response and cross‐talks with macrophages and dendritic cells
Authors: Kupani Manu , Pandey Rajeev K. , Mehrotra Sanjana 
Published: December 2020

AbstractNeutrophils with their array of microbicidal activities are the first innate immune cells to guard against infection. They are also most crucial for the host's initial defense against Leishmania parasites which cause clinically diverse diseases ranging from self‐healing cutaneous leishmaniasis (CL) to a more severe visceral form, visceral leishmaniasis (VL). Neutrophils are recruited in large numbers at the infection site after bite of sandfly, which is the vector for the disease. The initial interaction of neutrophils with the parasites may modulate the subsequent innate and adaptive immune responses and hence affect the disease outcome. The purpose of this review is to comprehensively appraise the role of neutrophils during the early stages of Leishmania infection with a focus on the visceral form of the disease. In the past decade, new insights regarding the role of neutrophils in VL have surfaced which have been extensively elaborated in the present review. In addition, since much of the information regarding neutrophil–Leishmania early interaction has accumulated through studies on mouse models of CL, these studies are also revisited. We begin by reviewing the factors which drive the recruitment of neutrophils at the site of injection by the sandfly. We then discuss the studies delineating the molecular mechanisms involved in the uptake of the Leishmania parasite by neutrophils and how the parasite subverts their microbicidal functions. In the end, the interaction of infected neutrophils with macrophages and dendritic cells is summarized.
Impact of failure rates, lot definitions and scheduling of upstream processes on the productivity of continuous integrated bioprocesses
Authors: Satzer Peter , Komuczki Daniel , Pappenreiter Magdalena , Cataldo Alessandro Luigi , Sissolak Bernhard , Jungbauer Alois 
Published: December 2020

AbstractBACKGROUNDThe failure rates and the scheduling of bioprocesses have a substantial impact on process performance and economics but are often overlooked and neglected. Integrated continuous biomanufacturing is more flexible in respect to scheduling and the impact of failures can be reduced by appropriate scheduling and lot definitions.RESULTSIn this work, we used a Monte Carlo approach on an integrated continuous biomanufacturing process with varying daily failure rates in the upstream and scheduling scenarios for seed fermentation (N‐1 stage) to quantify the impact on the actual productive uptime of the integrated process. The optimum targeted production time in the continuous upstream ranges between 45 and 90 days depending on the daily failure rate and the lot definition used for the process. We showed that a minimal flexibility for planning of the seed fermentation is necessary to harvest the full potential of integrated continuous biomanufacturing. A comparison with batch manufacturing in the upstream processing showed a higher productive uptime for continuous biomanufacturing regardless of daily failure rates. Computation of productive uptime for different lot definitions showed that a daily lot definition only shows a loss of 3% to a maximum of 5% productivity, depending on the daily failure rate, compared to a real‐time release approach.CONCLUSIONSWith this study, we provide a decision‐making tool for the scheduling of upstream processes and implementation of integrated continuous biomanufacturing taking failure into account, showing the extent to which planning of flexibility and batch definitions influence the productivity of continuous integrated bioprocesses. © 2020 The Authors. Journal of Chemical Technology & Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.