bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physiochemical and Microbiological Quality of Lightly Processed Salmon (Salmo salar L.) Stored Under Modified Atmosphere
Authors: Abel Nanna , Rotabakk Bjørn Tore , Rustad Turid , Ahlsen Vidar B. , Lerfall Jørgen 
Published: November 2019

AbstractLow‐temperature cooking, such as sous vide, has become a favored method for processing seafood. For this method to be applicable for retail products, combinations with other processing steps are needed to keep the products safe and durable while maintaining high quality. The present experiments were designed to investigate the influence of low‐temperature treatment (40, 50, or 60 °C) in combination with various packaging technologies (modified atmosphere [MA] or soluble gas stabilization [SGS]) on both the microbial growth and the physiochemical quality. Salmon loins were either kept natural or inoculated with Listeria innocua prior to drying (16 to 18 hr) in either 100% CO2 (SGS) or atmospheric air (MA packaging). All samples were sous vide treated, repackaged in MA, and stored at 4 °C for 24 days. The results showed shelf life to be significantly improved with the implementation of SGS, by prolonging the lag‐phase and slowing the growth rate of both naturally occurring and inoculated bacteria. Variations in packaging technology did not significantly influence any of the tested quality parameters, including drip loss, surface color, and texture. Growing consumer demand for lightly processed seafood products makes Listeria spp. an increasing problem. The present experiment, however, has shown that it is possible to lower processing temperatures to as little as 40 or 50 °C and still obtain inhibition of Listeria, but with improved chemical quality compared to traditional processing.
Exploring the relationship between body mass index, mental health and outcomes of a regional physiotherapy‐led post‐arthroplasty review clinic
Authors: Carney Sheena , Parker Carol , Schoo Adrian , Isaac Vivian , Kapakoulakis Theo 
Published: November 2019

AbstractObjectiveTo determine whether 12‐month hip and knee outcomes of a regional arthroplasty clinic were comparable to results from metropolitan‐based clinics, and to explore a possible relationship between body mass index and depression to identify groups at risk of not achieving optimal outcomes.DesignA prospective observational study.SettingA regional physiotherapy‐led post‐arthroplasty review clinic.ParticipantsPatients after hip or knee replacement.InterventionsPatients underwent either total hip or total knee joint arthroplasty.Main outcome measuresSF‐12 Health Survey, Oxford Hip/Knee Scale, 10‐minute walk test, knee range of motion, body mass index and the Hospital Anxiety and Depression Scale.ResultsPhysical outcomes were comparable to those reported by metropolitan‐based clinics. People with a high body mass index showed most improvement in the severity of depression compared to those with a lower body mass index.ConclusionIt is important to consider the long‐term effects of obesity on arthroplasty outcomes.
Variations in pulmonary fissural anatomy: a medicolegal autopsy study of 256 cases
Authors: Bostanci Korkut , Ozyurtkan Mehmet Oguzhan , Polat Mehmet Oguz , Batirel Hasan , Lacin Tunc , Yuksel Mustafa , Stamenovic Davor 
Published: November 2019

AbstractBackgroundWe aimed to document the anatomical variations of pulmonary fissures found during routine forensic autopsies.MethodsA total of 256 pairs of lungs were investigated. Presence of any variant and accessory fissures was noted.ResultsSeventy‐seven percent of the lungs had anatomical variations. In about 2/3 of the cases, oblique fissures were incomplete on both sides. The horizontal fissure was incomplete in 68.4%, and absent in 4.3% of the lungs. Twelve left lungs (4.7%) had a horizontal fissure. Accessory fissures were observed in 35 lungs (13.7%). Azygos lobe variations were detected in 1.7% of the lungs. A superior accessory fissure was present in 6.2% and 2% of right and left lungs, respectively.ConclusionThis and previous similar studies demonstrate the existence of several different anatomical fissural variations in the lungs. Clinicians, radiologists and surgeons should keep these in mind to better evaluate and treat their patients.
GATA2 deficiency and haematopoietic stem cell transplantation: challenges for the clinical practitioner
Authors: Bogaert Delfien J. , Laureys Genevieve , Naesens Leslie , Mazure Dominiek , De Bruyne Marieke , Hsu Amy P. , Bordon Victoria , Wouters Erik , Tavernier Simon J. , Lambrecht Bart N. , De Baere Elfride , Haerynck Filomeen , Kerre Tessa 
Published: November 2019

SummaryGATA2 deficiency, first described in 2011, is a bone marrow failure disorder resulting in a complex haematological and immunodeficiency syndrome characterised by cytopenias, severe infections, myelodysplasia and leukaemia. The only curative treatment is allogeneic haematopoietic stem cell transplantation (HSCT). Although knowledge on this syndrome has greatly expanded, in clinical practice many challenges remain. In particular, guidelines on optimal donor and stem cell source and conditioning regimens regarding HSCT are lacking. Additionally, genetic analysis of GATA2 is technically cumbersome and could easily result in false‐negative results. With this report, we wish to raise awareness of these pitfalls amongst physicians dealing with haematological malignancies and primary immunodeficiencies.
Ice‐margin retreat and grounding‐zone dynamics during initial deglaciation of the Storfjordrenna Ice Stream, western Barents Sea
Authors: Shackleton Calvin S. , Winsborrow Monica C. M. , Andreassen Karin , Lucchi Renata G. , Bjarnadóttir Lilja R. 
Published: November 2019

Processes occurring at the grounding zone of marine terminating ice streams are crucial to marginal stability, influencing ice discharge over the grounding‐line, and thereby regulating ice‐sheet mass balance. We present new marine geophysical data sets over a ~30×40 km area from a former ice‐stream grounding zone in Storfjordrenna, a large cross‐shelf trough in the western Barents Sea, south of Svalbard. Mapped ice‐marginal landforms on the outer shelf include a large accumulation of grounding‐zone deposits and a diverse population of iceberg ploughmarks. Published minimum ages of deglaciation in this region indicate that the deposits relate to the deglaciation of the Late Weichselian Storfjordrenna Ice Stream, a major outlet of the Barents Sea–Svalbard Ice Sheet. Sea‐floor geomorphology records initial ice‐stream retreat from the continental shelf break, and subsequent stabilization of the ice margin in outer‐Storfjordrenna. Clustering of distinct iceberg ploughmark sets suggests locally diverse controls on iceberg calving, producing multi‐keeled, tabular icebergs at the southern sector of the former ice margin, and deep‐drafted, single‐keeled icebergs in the northern sector. Retreat of the palaeo‐ice stream from the continental shelf break was characterized by ice‐margin break‐up via large calving events, evidenced by intensive iceberg scouring on the outer shelf. The retreating ice margin stabilized in outer‐Storfjordrenna, where the southern tip of Spitsbergen and underlying bedrock ridges provide lateral and basal pinning points. Ice‐proximal fans on the western flank of the grounding‐zone deposits document subglacial meltwater conduit and meltwater plume activity at the ice margin during deglaciation. Along the length of the former ice margin, key environmental parameters probably impacted ice‐margin stability and grounding‐zone deposition, and should be taken into consideration when reconstructing recent changes or predicting future changes to the margins of modern ice streams.
Development and characterization of a 99mTc‐labeled Neuropeptide Y short analog with potential application in breast cancer imaging
Authors: Cardoso María Elena , Tejería Emilia , Rey Ríos Ana María , Terán Mariella 
Published: November 2019

AbstractThe aim of this work was to develop and evaluate a 99mTc‐labeled neuropeptide Y derivative with affinity toward Y1‐receptor. The selected amino acid sequence included nine amino acids derived from the C‐terminal portion of the NPY complemented with the addition of one cysteine‐mercaptoacetic acid moiety to bind the radiometal. Labeling was achieved through the preparation of a 3 + 1 nitrido complex. Physicochemical evaluation, cell uptake, internalization and externalization studies, and competitive assays were performed. Biodistribution experiments were carried out in normal and tumor‐bearing mice. A single product with radiochemical purity >90% and high stability was obtained. In vitro analysis showed specific cellular uptake, IC50 of 73.2 nM, and a high internalization rate (80%). Biodistribution studies showed low blood and renal uptake and combined hepatobiliary and urinary elimination. Preliminary studies in mice bearing induced breast tumors rendered promising uptake values.
Self‐reported oral health at baseline of the Canadian Longitudinal Study on Aging
Authors: Bassim Carol W. , MacEntee Michael I. , Nazmul Sohel , Bedard Chloe , Liu Siying , Ma Jinhui , Griffith Lauren E. , Raina Parminder 
Published: November 2019

AbstractObjectivesTo compare the prevalence of poor self‐reported oral health (SROH) and dental service‐use in a representative sample of Canadian residents, and to identify associations between SROH and psychosocial determinants of health at baseline of the Canadian Longitudinal Study on Aging.MethodsData from baseline interviews from 2010 to 2015 involving 93% of 51 388 adults (n = 47 761) were weighted to compare the prevalence of oral health characteristics adjusted for age, sex, socioeconomics, general health and residence. SROH was assessed as ‘excellent’, ‘very good’, ‘good’, ‘fair’ or ‘poor’, and dichotomized as ‘fair/poor’ and ‘good/very good/excellent’. Multivariable logistic regression was used to assess the association of fair/poor oral health with psychosocial determinants of health.ResultsMost participants reported ‘good/very good/excellent’ oral health (92.5%), natural teeth (92.0%) and dental service‐use in the previous year (79.6%), yet over 10% had discomfort when eating. Reports of ‘fair/poor’ oral health were significantly more frequent among participants who had dental concerns, had low socioeconomic status, smoked tobacco or reported poor general health. Dental service‐use and tooth loss differed by province. The odds of poor/fair SROH were high (odds ratio ≥1.5) among participants who avoided foods, did not use dental services frequently, had low incomes, smoked tobacco, were depressed, felt unhealthy or had multiple chronic conditions, but by neither sex or age. There were no interprovincial differences.ConclusionsMost Canadian residents feel in good oral health and use dental services. Oral health inequality is evident between different socioeconomic groups and between healthy and unhealthy people. SROH is strongly associated with socioeconomic and general health status but not with place of residence. However, there were substantial differences in reports of tooth loss and dental service‐use across provinces.
Relationship between self‐rated pain and peri‐implant clinical, radiographic and whole salivary inflammatory markers among patients with and without peri‐implantitis
Authors: Abduljabbar Tariq , Vohra Fahim , Ullah Anhar , Alhamoudi Nawaf , Khan Junad , Javed Fawad 
Published: November 2019

AbstractBackgroundThere are no studies that have evaluated the correlation between self‐rated pain, peri‐implant clinical and radiographic parameters (plaque index [PI], bleeding on probing [BOP], probing depth [PD], and crestal bone loss [CBL]) and whole salivary interleukin (IL)‐1β, IL‐6, and tumor necrosis factor‐alpha (TNF‐α) levels among patients with and without peri‐implantitis.PurposeThe objective was to evaluate the correlation between self‐evaluated pain, peri‐implant clinical and radiographic parameters and whole salivary IL‐1β, IL‐6, and TNF‐α levels among patients with and without peri‐implantitis.Materials and MethodsIncluded in this study were patients with and without peri‐implantitis. Data regarding age, gender, duration of implants in function, and self‐perceived pain were recorded using a question. Self‐rated pain was assessed using the numeric pain rating scale. Peri‐implant PD, PI, BOP, and CBL were recorded and samples of unstimulated whole saliva samples were obtained. Whole salivary IL‐1β, IL‐6, and TNF‐α were measured. Sample‐size was approximated and group comparisons were completed.P‐values <.05 were regarded as statistically significant.ResultsForty‐six male individuals (21 with and 25 without peri‐implantitis) were included. The mean age of individuals with and without PiD was 53.71 ± 5.45 and 50.92 ± 6.26 years, respectively. The mean self‐rated pain score in patients with and without PiD was 3 ± 2 and zero, respectively. There was no significant difference in the SFR among patients with and without peri‐implantitis. Levels of IL‐1β (P < .01), IL‐6 (P < .01), and TNF‐α (P < .01) were significantly elevated in subjects with than without peri‐implantitis. Regression analysis‐based results reflected no significant association between increasing self‐rated pain and whole salivary IL‐1β, IL‐6, and TNF‐α levels.ConclusionProinflammatory cytokines (IL‐1β, IL‐6, and TNF‐α) are more often expressed in the UWS of patients with than without peri‐implantitis. However, the correlation between self‐rated pain and whole salivary proinflammatory cytokine profile in patients with peri‐implantitis remains unclear.
Ecosystem indices to support global biodiversity conservation
Authors: Rowland Jessica A. , Bland Lucie M. , Keith David A. , Juffe‐Bignoli Diego , Burgman Mark A. , Etter Andres , Ferrer‐Paris José Rafael , Miller Rebecca M. , Skowno Andrew L. , Nicholson Emily 
Published: November 2019

AbstractGovernments have committed to global targets to slow biodiversity loss and sustain ecosystem services. Biodiversity state indicators that measure progress toward these targets mostly focus on species, while indicators synthesizing ecosystem change are largely lacking. We fill this gap with three indices quantifying past and projected changes in ecosystems using data from the International Union for Conservation of Nature (IUCN) Red List of Ecosystems. Our indices quantify changes in risk of ecosystem collapse, ecosystem area and ecological processes, and capture variation in underlying patterns among ecosystems. We apply the indices to three case studies of regional and national assessments (American/Caribbean forests, terrestrial ecosystems of Colombia, and terrestrial ecosystems of South Africa) to illustrate the indices’ complementarity and versatility in revealing patterns of interest for users across sectors. Our indices have the potential to fill the recognized need for ecosystem indicators to inform conservation targets, guide policy, and prioritize management actions.
Seizure freedom improves health‐related quality of life after epilepsy surgery in children
Authors: Jain Puneet , Smith Mary Lou , Speechley Kathy , Ferro Mark , Connolly Mary , Ramachandrannair Rajesh , Almubarak Salah , Andrade Andrea , Widjaja Elysa ,   Pepsqol Study Team
Published: November 2019

AimTo determine whether epilepsy surgery improved health‐related quality of life (HRQoL) and whether seizure freedom after surgery mediated the improvement in HRQoL.MethodThis multicenter cohort study compared HRQoL after epilepsy surgery to pharmacological management in children with drug‐resistant epilepsy (DRE). HRQoL was measured using the Quality of Life in Childhood Epilepsy (QOLCE) questionnaire at baseline and 1‐year follow‐up. The mediator between treatment type and HRQoL was seizure freedom.ResultsTwo hundred and thirty‐seven patients were recruited (surgery group: n=147 [92 males, 45 females]; pharmacological group: n=90 [53 males, 37 females]). Mean age at seizure onset was 6 years (SD 4y 4mo) in the surgical group and 6 years 1 month (SD 4y) in the pharmacological group. The odds ratio of seizure freedom was higher for the surgery versus pharmacological group (β=4.24 [95% confidence interval {CI}: 2.26–7.93], p<0.001). Surgery had no direct effect on total QOLCE score at 1‐year (β=0.24 [95% CI –2.04 to 2.51], p=0.839) compared to pharmacological management, but had an indirect effect on total QOLCE that was mediated by seizure freedom (β=0.92 [95% CI 0.19–1.65], p=0.013), adjusting for baseline total QOLCE score. Surgery had a direct effect on improving social function (p=0.043), and an indirect effect on improving physical function (p=0.016), cognition (p=0.042), social function (p=0.012) and behavior (p=0.032), mediated by seizure freedom.InterpretationGreater seizure freedom achieved through epilepsy surgery mediated the improvement in HRQoL compared to pharmacological management in children with DRE.What this paper adds

Seizure freedom is higher after pediatric epilepsy surgery compared to pharmacologically managed epilepsy.

Surgery indirectly improves health‐related quality of life (HRQoL) mediated by seizure freedom compared to pharmacological management.

Surgery has a direct effect on improving social function relative to pharmacological management.

Baseline HRQoL was an important predictor of HRQoL after treatment.
Foreseeing the future of mutualistic communities beyond collapse
Authors: Lever J. Jelle , van de Leemput Ingrid A. , Weinans Els , Quax Rick , Dakos Vasilis , van Nes Egbert H. , Bascompte Jordi , Scheffer Marten 
Published: November 2019

AbstractChanging conditions may lead to sudden shifts in the state of ecosystems when critical thresholds are passed. Some well‐studied drivers of such transitions lead to predictable outcomes such as a turbid lake or a degraded landscape. Many ecosystems are, however, complex systems of many interacting species. While detecting upcoming transitions in such systems is challenging, predicting what comes after a critical transition is terra incognita altogether. The problem is that complex ecosystems may shift to many different, alternative states. Whether an impending transition has minor, positive or catastrophic effects is thus unclear. Some systems may, however, behave more predictably than others. The dynamics of mutualistic communities can be expected to be relatively simple, because delayed negative feedbacks leading to oscillatory or other complex dynamics are weak. Here, we address the question of whether this relative simplicity allows us to foresee a community's future state. As a case study, we use a model of a bipartite mutualistic network and show that a network's post‐transition state is indicated by the way in which a system recovers from minor disturbances. Similar results obtained with a unipartite model of facilitation suggest that our results are of relevance to a wide range of mutualistic systems.
Exploring Processes in Day‐to‐Day Parent–Adolescent Conflict and Angry Mood: Evidence for Circular Causality
Authors: LoBraico Emily J. , Brinberg Miriam , Ram Nilam , Fosco Gregory M. 
Published: November 2019

Parent–adolescent conflict has been studied both as a precursor of long‐term macrolevel developmental risks and as an outcome of microlevel, moment‐to‐moment interaction patterns. However, the family‐level processes underlying the maintenance or regulation of conflict in daily life are largely overlooked. A meso‐level understanding of parent–adolescent conflict offers important practical insights that have direct implications for interventions. The present study explores day‐to‐day reciprocal processes and carryover in parents’ and adolescents’ experiences of anger and conflict. Daily diary data provided by parent–adolescent dyads (N = 151) from two‐caregiver households (adolescents: 61.59% female, mean age = 14.60 years) over 21 days were examined using a multivariate Poisson multilevel model to evaluate the circular causality principle in parents’ and adolescents’ daily conflict and anger. Findings offer empirical support for the theory, suggesting that parents’ and adolescents’ anger and conflict exist together in a feedback loop wherein conflict is both a consequence of past anger and also an antecedent of future anger, both within and across persons. Increased understanding of the daily interaction patterns and maintenance of parent–adolescent conflict can guide more informed, targeted, and well‐timed interventions intended to ameliorate the consequences of problematic parent–adolescent conflict sequences.
Associations between accelerometry measured physical activity and sedentary time and the metabolic syndrome: A meta‐analysis of more than 6000 children and adolescents
Authors: Renninger Marius , Hansen Bjørge H. , Steene‐Johannessen Jostein , Kriemler Susi , Froberg Karsten , Northstone Kate , Sardinha Luis , Anderssen Sigmund A. , Andersen Lars B. , Ekelund Ulf ,   On behalf of the International Children's Accelerometry Database (ICAD) Collaborators
Published: November 2019

SummaryBackgroundMetabolic syndrome is increasingly prevalent in the pediatric population. To prevent an early onset, knowledge about its association with modifiable lifestyle factors is needed.ObjectivesTo estimate the prevalence of the metabolic syndrome and examine its cross‐sectional associations with physical activity and sedentary time.MethodsParticipants were 6009 children and adolescents from 8 studies of the International Children's Accelerometry Database. Physical activity and sedentary time were measured by accelerometer. Metabolic syndrome was defined based on International Diabetes Federation criteria. Logistic regression models adjusted for sex, age and monitor wear time were used to examine the associations between physical activity, sedentary time and the metabolic syndrome in each study and effect estimates were combined using random‐effects meta‐analysis.ResultsThe overall prevalence of the metabolic syndrome was 2.9%. In crude models, a 10 min increase in moderate‐to‐vigorous intensity physical activity and vigorous‐intensity physical activity were inversely associated with the metabolic syndrome [OR 0.88, 95% CI 0.82‐0.94, OR 0.80, 95% CI 0.70‐0.92]. One hour increase in sedentary time was positively associated with the metabolic syndrome [OR 1.28, 95% CI 1.13‐1.45]. After adjustment for sedentary time, the association between moderate‐to‐vigorous‐intensity physical activity and the metabolic syndrome remained significant [OR 0.91, 95% CI 0.84‐0.99]. Sedentary time was not associated with the metabolic syndrome after adjustment for moderate‐to‐vigorous intensity physical activity [OR 1.14 95% CI 0.96‐1.36].ConclusionsPhysical activity of at least moderate intensity but not sedentary time is independently associated with the metabolic syndrome.
Whole parasite vaccines for the asexual blood stages of Plasmodium
Authors: Good Michael F. , Stanisic Danielle I. 
Published: November 2019

AbstractAfter many decades of research, an effective vaccine for malaria is still not available. Most research efforts have focused on identifying a key target antigen and then using powerful adjuvants to generate specific antibodies that can block parasites from entering host cells (hepatocytes, red blood cells). However, the inability to generate sufficiently potent antibody responses has led to significant disappointment with current vaccine programs. An additional challenge for sub‐unit vaccines is that key vaccine antigens are highly polymorphic. These challenges have spurred radically different approaches to malaria vaccine development. Many of these involve the use of “whole parasites”—either extracted from mosquitoes or cultured. With these, every parasite molecule for that particular strain is included in the vaccine. This strategy is showing great promise following several clinical trials with irradiated sporozoites. However, a whole‐parasite approach to a blood stage vaccine has not advanced as quickly. This article outlines the history, the different approaches that are being taken and the challenges associated with whole parasite blood stage vaccines and discusses recent exciting developments as these vaccines now move into the clinic.