bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction of Clinical Biobanks and the Medical Ethics
Authors: Yu Meng , Yan Qingyu , Zhang Chi , Wu Feixiang , Du Chen , Song Weihua 
Published: July 2020

<p>Nowadays, various types and forms of clinical biobanks have been gradually established worldwide, which have become one of the important components and research platforms of life science and related disease researches in the medical system. This article mainly introduces the construction, management and operation of clinical biobanks, and discusses the medical ethics faced by it.</p>
An An assessment of the impact of educational interventions on hand hygiene compliance
Authors: Husband Carla , McMillan Abbie , Sweeney Lauren 
Published: July 2020

PICO question
In small animal veterinary professions, does implementation of an educational intervention, when compared to no intervention, improve hand hygiene compliance?

Clinical bottom line
Category of research question
Treatment
The number and type of study designs reviewed
Three papers were critically appraised. They were all prospective observational cohort studies
Strength of evidence
Weak
Outcomes reported
Two out of the three papers did not find educational implementation to have a statistically significant positive effect on hand hygiene compliance (HHC) in small animal veterinary professionals
Conclusion
The veterinary evidence reviewed does not provide strong justification for the use of education in the improvement of HHC in small animal practice. This contrasts with extensive human evidence which supports the use of educational interventions (Helder et al., 2010). However, a limited veterinary knowledge base in the field of HH, combined with the flawed methodologies of the appraised literature, suggests that this finding is not representative of the effect education could have on HHC.
The conclusion drawn from the evidence assessed within this Knowledge Summary is that educational interventions are not significantly linked to an improvement in HHC within a small animal veterinary setting. When considering the volume of human evidence which supports education as a tool to improve HHC, the authors suggest this Knowledge Summary should be repeated in the future when additional veterinary evidence is available to reassess the conclusion drawn

How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision-making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
LINGUISTICS POLITENESS MARKERS IN AUSTRALIAN EMBASSY IN INDONESIA’S SOCIAL MEDIA
Authors: Hamidah Hamidah , Anwar Miftahulkhairah , Rohman Saifur 
Published: July 2020

ABSTRACT:
This article analyzes the types of politeness markers on the social media of Australian Embassy in Indonesia. This research used descriptive qualitative method with content analysis techniques. Data sources taken from Instagram and Facebook which retrieval during 2017. The data was selected based on educational and cultural themed. This reaserch found that there were 55 politeness markers included in 15 forms, there are semoga, kamu bisa, apakah, selamat, bentuk sapaan hormat, ayo atau yuk, bentuk sapaan akrab, sangat dianjurkan, asyik ya, tak sabar, tahukah kamu, sebaiknya, bagaimana, sukses untuk studinya, kami mendoakan yang terbaik, and kami ingin mengucapkan selamat.
Keywords: politeness; politeness markers; Australian Embassy in Indonesia’s Social Media
PENGEMBANGAN PENDIDIKAN ISLAM MELALUI PEMBELAJARAN EFEKTIF SEKOLAH DASAR ISLAM TERPADU
Authors: Sabiq Fairuz 
Published: July 2020

<p align="center">Pendidikan Islam memainkan peranan yang sangat penting dalam membentuk generasi yang siap menghadapi era globalisasi yang penuh dengan tantangan. Pendidikan Islam harus mampu menyelengarakan proses pembekalan pengetahuan, penanaman nilai, pembentukan sikap dan karakter, pengembangan bakat, kemampuan dan keterampilan, menumbuhkembangkan potensi akal, jasmani dan rohani yang optimal, seimbang dan sesuai dengan tuntutan zaman. Namun pada kenyataanya, pendidikan Islam khususnya di Indonesia telah berjalan dalam lorong krisis yang panjang. Pendidikan Islam telah kehilangan pijakan filosofisnya yang hakiki, yang kemudian berdampak pada tidak jelasnya arah dan tujuan yang hendak dicapai. Untuk menjawab permasalahan tersebut, munculah gagasan Pendidikan Islam Terpadu; sebuah model pendidikan yang didesain dengan segala keterpaduan dari berbagai sisi dan aspek pendidikan yang meliputi visi, misi, kurikulum, pendidik, suasana pembelajaran dan lain sebagainya. Sekolah Islam Terpadu sebagai bentuk satuan pendidikan memiliki peran yang strategis dalam membentuk, membangun, membina dan mengarahkan siswa menjadi manusia yang seutuhnya, manusia yang berkarakter dan berkepribadian yang positif, memahami diri sendiri, terampil dan mampu berkerja sama dengan orang lain. Salah satunya adalah SD Islam Terpadu Hidayah Klaten yang menerapkan konsep rabbaniyah, integratif, stimulatif, fasilitatif, inovatif, dan motivatif dalam kurikulumnya.</p>
THE ACTUALIZATION OF INTEGRATIVE THEMATIC LEARNING IN MADRASAH IBTIDAIYAH (MI) THROUGH ARIAS LEARNING MODEL
Authors: Hadi Nur 
Published: July 2020

<p align="center"><em>This paper aims to describe how to actualize integrative thematic learning that takes place in Madrasah Ibtidaiyah (MI) where during this time the educator sometimes still confused how to do the step, what strategy should be used, what model should be chosen in doing the learning process. A thing that must be done by educators for integrative thematic learning can be implemented properly one of them is by using ARIAS learning model. The ARIAS learning model is able to make integrative thematic learning work well. Because the learning model ARIAS is a learning system characterized by a systematic learning environment, meaningful and simple, able to provide comfort learners follow the learning activities, able to develop students' reasoning ability, able to acquire and mastery of new material, able to foster self-confidence learners, able to grow interest and attention of learners, able to cultivate a sense of pride and satisfaction of learners in following the learning.</em></p><p> </p>
Telemental Health and US Rural–Urban Differences in Specialty Mental Health Use, 2010–2017
Authors: Patel Sadiq Y. , Huskamp Haiden A. , Busch Alisa B. , Mehrotra Ateev 
Published: July 2020

Objectives. To examine whether growing use of telemental health (TMH) has reduced the rural–urban gap in specialty mental health care use in the United States. Methods. Using 2010–2017 Medicare data, we analyzed trends in the rural–urban difference in rates of specialty visits (in-person and TMH). Results. Among rural beneficiaries diagnosed with schizophrenia or bipolar disorder, TMH use grew by 425% over the 8 years and, in higher-use rural areas, accounted for one quarter of all specialty mental health visits in 2017. Among patients with schizophrenia or bipolar disorder, TMH visits differentially grew in rural areas by 0.14 visits from 2010 to 2017. This growth partially offset the 0.42-visit differential decline in in-person visits in rural areas. In net, the gap between rural and urban patients in specialty visits was larger by 2017. Conclusions. TMH has improved access to specialty care in rural areas, particularly for individuals diagnosed with schizophrenia or bipolar disorder. While growth in TMH use has been insufficient to eliminate the overall rural–urban difference in specialty care use, this difference may have been larger if not for TMH. Public Health Implications. Targeted policy to extend TMH to underserved areas may help offset declines in in-person specialty care.
Immigration Status and Disparities in the Treatment of Cardiovascular Disease Risk Factors in the Hispanic Community Health Study/Study of Latinos (Visit 2, 2014–2017)
Authors: Guadamuz Jenny S. , Durazo-Arvizu Ramon A. , Daviglus Martha L. , Perreira Krista M. , Calip Gregory S. , Nutescu Edith A. , Gallo Linda C. , Castaneda Sheila F. , Gonzalez Franklyn , Qato Dima M. 
Published: July 2020

Objectives. To estimate treatment rates of high cholesterol, hypertension, and diabetes among Hispanic/Latino immigrants by immigration status (i.e., naturalized citizens, documented immigrants, or undocumented immigrants). Methods. We performed a cross-sectional analyses of the Hispanic Community Health Study/Study of Latinos (visit 2, 2014–2017). We restricted our analysis to Hispanic/Latino immigrants with high cholesterol (n = 3974), hypertension (n = 3353), or diabetes (n = 2406); treatment was defined as use of statins, antihypertensives, and antidiabetics, respectively. Results. When compared with naturalized citizens, undocumented and documented immigrants were less likely to receive treatment for high cholesterol (38.4% vs 14.1%; prevalence ratio [PR] = 0.37 [95% confidence interval [CI] = 0.27, 0.51] and 25.7%; PR = 0.67 [95% CI = 0.58, 0.76]), hypertension (77.7% vs 57.7%; PR = 0.74 [95% CI = 0.62, 0.89] and 68.1%; PR = 0.88 [95% CI = 0.82, 0.94]), and diabetes (60.3% vs. 50.4%; PR = 0.84 [95% CI = 0.68, 1.02] and 55.8%; PR = 0.93 [95% CI = 0.83, 1.03]); the latter did not reach statistical significance. Undocumented and documented immigrants had less access to health care, including insurance coverage or a usual health care provider, than naturalized citizens. Therefore, adjusting for health care access largely explained treatment disparities across immigration status. Conclusions. Preventing cardiovascular disease among Hispanic/Latino immigrants should focus on undertreatment of high cholesterol, hypertension, and diabetes by increasing health care access, especially among undocumented immigrants.
E-cigarette Tobacco Retail Licensing Laws: Variance Across US States as of January 1, 2020
Authors: Patel Minal , Donovan Emily M. , Perks Siobhan N. , Huang Darlene , Czaplicki Lauren , Akbar Maham , Gagosian Stacey , Schillo Barbara A. 
Published: July 2020

Objectives. To describe how US states and the District of Columbia regulate e-cigarette sales by examining e-cigarette–specific tobacco retail licensing (TRL) laws. Methods. We coded 25 state-level e-cigarette TRL laws (effective as of January 1, 2020) for provisions we labeled as either “core” (e.g., presence of license terms, fees, and penalties) or “descriptive” (e.g., license fee amount and term length). Results. Overall, 23 laws clearly defined a license term, 23 laws required a license fee, and 19 laws identified penalties for violations that included both license suspension and revocation. Fees widely ranged ($5–$1000 annually), and 8 laws did not explicitly direct fees toward TRL administration or enforcement. No law required that retailers comply with all local, state, and federal tobacco or e-cigarette laws. Conclusions. Most laws contained core TRL provisions. Several laws, however, had minimal license fees and did not direct fees toward administration or enforcement. As youth e-cigarette use increases, more states should consider establishing e-cigarette TRL laws or incorporating provisions into existing TRL laws.
Infertility Treatment in France, 2008–2017: A Challenge of Growing Treatment Needs at Older Ages
Authors: Ben Messaoud Khaoula , Bouyer Jean , de La Rochebrochard Elise 
Published: July 2020

Objectives. To measure trends in infertility treatment use between 2008 and 2017 in France using data from the national health insurance system. Methods. Between 2008 and 2017, we observed a representative national sample of nearly 1% of all women aged 20 to 49 years who were affiliated with the main health insurance scheme in France (more than 100 000 women observed each year). We exhaustively recorded all health care reimbursed to these women. Results. Among women aged 20 to 49 years, 1.25% were treated for infertility each year. Logistic regression analysis showed a significant interaction between age and year of treatment use (P < .001). Over the decade, infertility treatment use increased by 23.9% among women aged 34 years or older, whereas among women younger than 34 years there was a nonsignificant variation. Conclusions. Women aged 34 years or older were increasingly treated for infertility between 2008 and 2017. Public Health Implications. Treatment efficiency decreases strongly with a woman’s age, presenting a challenge for medical infertility care.
PEMBUATAN PUPUK ORGANIK SEBAGAI UPAYA PENGURANGAN KETERGANTUNGAN PETANI TERHADAP PUPUK KIMIA DI DUSUN SIDOWAYAH, DESA CANDIMULYO, KECAMATAN DOLOPO, KABUPATEN MADIUN
Authors: Marwantika Asna Istya 
Published: July 2020

Pupuk organik menjadi salah satu pilihan para petani untuk mengembalikan produktivitas tanah dan meningkatkan hasil produksi pertaniannya. Setelah selama ini petani di Dusun Sidowayah, Desa Candimulyo, Kecamatan Dolopo, Kabupaten Madiun lebih banyak menggunakan pupuk kimia untuk pertanian. Faktor kemudahan memperoleh barang dan menggunakan pupuk kimia memang menjadi faktor utama pemakaian pupuk kimia. Varian Urea, ZA sudah terbukti dan dirasakan mujarab dalam meningkatkan produksi pertanian, baik itu untuk tanaman padi maupun jagung. Tetapi dibalik itu tentunya ada beberapa bahaya pupuk kimia seperti penggunaan yang berkepanjangan justru akan merusak unsur kesuburan tanah, dan juga hasil pertaniannya mengandung zat kimia, kemudian bisa mengendap dan menyebabkan penyakit di tubuh manusia jika dikonsumsi secara terus menerus. Bahaya akan penggunaan pupuk kimia ini rupanya mulai direspon oleh masyarakat dusun Sidowayah setelah melihat aset dengan metode Asset Based Community Development ditemukan aset berupa kotoran sapi dan kotoran kambing yang diolah menjadi pupuk organik.
Social participation is an important health behaviour for health and quality of life among chronically ill older Chinese people
Authors: Feng Zeyun , Cramm Jane Murray , Nieboer Anna Petra 
Published: July 2020

Abstract
Background: Health behaviours (physical activity, maintenance of a healthy diet and not smoking) are known to be beneficial to the health and well-being of chronically ill people. With China's ageing population and increased prevalence of people with chronic diseases, the improvement of unhealthy behaviours in this population has become crucial. Although recent studies have highlighted the importance of social participation for health and quality of life (QoL) among older people, no study to date has included social participation along with more traditional health behaviours. Therefore, this study aimed to identify associations of multiple health behaviours (social participation, physical activity, maintenance of a healthy diet and not smoking) with health and QoL outcomes (including cognitive and physical function) among chronically ill older adults in China.Methods: For this nationally representative cross-sectional study, wave 1 data from the World Health Organization’s Study on global AGEing and adult health (China) were examined. In total, 6,629 community-dwelling older adults (mean age, 64.9 years) with at least one chronic disease were included. Multivariate linear regression analyses were used to evaluate associations of health behaviours with health and QoL outcomes while controlling for background characteristics.Results: Greater social participation was associated with better QoL [β = 0.127, standard error (SE) = 0.002, p < 0.001], cognitive function (β = 0.154, SE = 0.033, p < 0.001) and physical function (β = –0.102, SE = 0.008, p < 0.001). Physical activity was associated with better QoL (β = 0.091, SE = 0.015, p < 0.001) and physical function (β = –0.155, SE = 0.062, p < 0.001). Sufficient fruit and vegetable consumption was associated with better QoL (β = 0.087, SE = 0.015, p < 0.001).Conclusions: Our findings suggest that social participation is an important health behaviour for quality of life and cognitive function among chronically ill older people in China. Health promotion programmes should expand their focus to include social participation as a health behaviour, in addition to physical activity, maintenance of a healthy diet and not smoking.
Therapeutic Effect of Dual CAR-T Targeting PDL1 and MUC16 Antigens on Ovarian Cancer Cells in Mice
Authors: Li Tong , Wang Jiandong 
Published: July 2020

Abstract
Background: More favorable treatment against epithelial ovarian cancer (EOC) is urgently needed because of its insidious nature at an early stage and a low rate of five-year survival. The current primary treatment, extensive surgery combined with chemotherapy, exhibits limited benefits for improving prognosis. Chimeric antigen receptor T (CAR-T) cell technology as novel immunotherapy has made breakthrough progress in the treatment of hematologic malignancies, and there were also benefits shown in a partial solid tumor in previous research. Therefore, CAR-T cell technology may be a promising candidate as an immunotherapeutic tool against EOC. However, there are some weaknesses in targeting one antigen from the previous preclinical assay, such as on-target off-tumor cytotoxicity. The dual-target CAR-T cell may be a better choice.Methods: We constructed tandem PD1-antiMUC16 dual-CAR, PD1 single-CAR, and anti-MUC16 single-CAR fragments by PCR and genetic engineering, followed by preparing CAR-T cells via lentiviral infection. The expression of CAR molecules on single and dual CAR-T cells was detected by flow cytometry. The killing capacity and activation of CAR-T cells were measured by cytotoxic assays and cytokines release assays in vitro. The therapeutic capacity of CAR-T cells was assessed by tumor-bearing mice model assay in vivo.Results: We successfully constructed CARs lentiviral expression vectors and obtained single and dual CAR-T cells. CAR-T cells demonstrated robust killing capacity against OVCAR-3 cells in vitro. Meanwhile, CAR-T cells released plenty of cytokines such as interleukin-2(IL-2), interferon-γ (IFN-γ) and tumor necrosis factor-α(TNF-α). CAR-T cells showed a therapeutic benefit against OVCAR-3 tumor-bearing mice and significantly prolonged the survival time. Dual CAR-T cells were shown to be two to four times more efficacious than single CAR-T cells in terms of survival time. Conclusion: Although exhibiting a similar ability as single CAR-T cells against OVCAR-3 cells in vitro, dual CAR-T cells demonstrated enhanced killing capacity against OVCAR-3 cells as compared to single CAR-T cells in vivo and significantly prolonged the survival time of tumor-bearing mice. PD1-antiMUC16 CAR-T cells showed more potent antitumor activity than single CAR-T cells in vivo. The present experimental data may support further research work that will have the potential to lead to clinical studies.
Diversity patterns of soil microbial communities in the Sophora flavescens rhizosphere in response to continuous monocropping
Authors: Lei Haiying , Liu Ake , Zhao Qingsong , Hou Qinwen , Guo Jia , Wang Zhijun 
Published: July 2020

Abstract
Background: Continuous monocropping can affect the physicochemical and biological characteristics of cultivated soil. Sophora flavescens is a valuable herbal medicine and sensitive to continuous monocropping. Currently, diversity patterns of soil microbial communities in soil continuous monocropping with S. flavescens have not been extensively elucidated. Results: In this study, comparative 16S rDNA and internal transcribed spacer (ITS) MiSeq sequencing analyses were used to examine the taxonomic community structure and microbial diversity in nonrhizosphere soil (CK) and rhizosphere soils (SCC, TCC, and FCC) sampled from fields that had undergone two, three, and five years of continuous monocropping, respectively. Among the microbial communities, a decreased abundance of Acidobacteria and increased abundances of Proteobacteria and Bacteroidetes were found with the increase in monocropping years of S. flavescens . As the continuous monocropping time increased, the diversity of the bacterial community decreased, but that of fungi increased. Redundancy analysis also showed that among the properties of the rhizosphere soil, the available phosphorus, organic matter, total nitrogen, and sucrase had the greatest impacts on the diversity of the rhizosphere microbial community. Moreover, a biomarker for S. flavescens soil was also identified using the most differentially abundant bacteria and fungi in soil samples. Conclusions: Our study indicates that long-term monocropping exerted great impacts on microbial community distributions and soil physicochemical properties. The relationship between microbial community and physicochemical properties of rhizosphere soil would help clarify the side effects of continuous S. flavescens monocropping. Our study may aid in uncovering the theoretical basis underlying obstacles to continuous monocropping and provide better guidance for crop production.
Clinical characteristics, treatment and outcome of adnexal torsion in pregnant women: a retrospective study
Authors: Wang Yong-xue , Deng Shan 
Published: July 2020

Abstract
Background: Adnexal torsion during pregnancy is a gynecological emergency. Delayed diagnosis and treatment can cause ovarian necrosis and fetal loss. This study assessed the clinical characteristics, treatment and outcomes of adnexal torsion in pregnant women.Methods: A retrospective study was conducted at a tertiary center between January 2008 and January 2018. Eighty-two pregnant women with surgically confirmed adnexal torsion were included. The clinical characteristics, ultrasound data, surgical interventions and pregnancy outcomes were analyzed.Results: The median age of the patients was 28 (range, 18-38) years. The median gestational age was 11 (range, 6-31) weeks: 53 (64.6%) were in the first trimester, 21 (25.6%) were in the second trimester, and 8 (9.8%) were in the third trimester. The most common symptoms and signs were sudden pelvic pain (100%) and adnexal or pelvic masses (97.6%), followed by nausea and vomiting (61%). The Doppler blood flow signal disappeared in 62.5% of the patients. Sixty-three (76.8%) patients underwent laparoscopy, and 29 (24.2%) underwent laparotomy. The median gestational age in patients undergoing laparotomy was higher than that in those undergoing laparoscopy (26 weeks vs 10 weeks, p<0.001). Fifty-three (64.6%) patients underwent conservative surgery, with 48 detorsions and cystectomies, 2 detorsions and cyst fenestrations, 1 detorsion only and 2 salpingectomies only. Twenty-nine (25.4%) patients underwent unilateral salpingo-oophorectomy. There were no cases of postoperative thrombosis, spontaneous abortion or recurrence during the same pregnancy. Seven patients underwent simultaneous artificial abortion. One patient experienced intrauterine fetal death, and 74 patients had live births.Conclusion: Surgical intervention was required as soon as possible. Laparoscopic conservative surgery is safe and may be appropriate to preserve ovarian function.