bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autologous platelet concentrates in maxillofacial regenerative therapy
Authors: Chou Tsau‐Mau , Chang Hong‐Po , Wang Jen‐Chyan 
Published: February 2020

AbstractPlatelet concentrates have emerged as innovative autologous blood products that enhance tissue healing and regeneration in regenerative therapy. A common feature of these products is their higher than baseline platelet concentration, which improves wound healing and tissue repair. Four main categories of products can be easily defined, based on their leukocyte content and fibrin architecture: pure platelet‐rich plasma, such as Cell Separator PRP or Anitua' PRGF; leukocyte‐ and platelet‐rich plasma (L‐PRP), such as PCCS or Ace PRP; pure platelet‐rich fibrin (P‐PRF), such as Fibrinet PRFM; and leukocyte‐ and platelet‐rich fibrin (L‐PRF), such as Choukroun's PRF. Two families contain significant concentrations of leukocytes: L‐PRP and L‐PRF. These four families of products have different biological signatures and mechanisms and obviously different clinical applications. An L‐PRF membrane releases growth factors and matrix proteins over a period longer than 7 days, whereas a PRP gel matrix releases and disperses its growth factors in a relatively quick download. In the near future, simple and inexpensive products such as L‐PRF are expected to have applications in oral‐maxillofacial surgery, periodontal surgery, plastic surgery, orthopedic surgery, and sports medicine. Leukocytes substantially affect the intrinsic biology and properties of platelet concentrates, not only because they enhance immune function and antibacterial potential, but also because they have essential roles in the wound healing process. Unfortunately, their impact has been almost completely neglected in the literature. Improved understanding of the effects of leukocytes in wound healing is essential for development of new clinical applications of platelet concentrates.
Spatiotemporal characteristics analysis of multifunctional cultivated land: A case‐study in Shenyang, Northeast China
Authors: Qian Fengkui , Chi Yanru , Lal Rattan 
Published: February 2020

AbstractThe configuration of multifunctional cultivated land is critical for its protection. Although studies on multifunctional cultivated land have been conducted, there is a lack of information regarding the spatiotemporal characteristics and tradeoff synergy relationship of cultivated‐land functions at the same time on a nonadministrative unit scale. The purpose of this study was to analyze the spatial distribution characteristics and the tradeoff synergy areas from the perspective of multifunctional cultivated land for efficient use of land resources to minimize the conflict between people and nature. The fuzzy optimization model and spatial autocorrelation analysis method were used to study spatial distribution characteristics and the tradeoff synergy spatial patterns, respectively. The results showed that (a) the implementation of different improvement measures for the spatial distribution characteristics of cultivated‐land functions could also accelerate the coordinated development of cultivated‐land functions, (b) multiple functions of cultivated land not only had a synergy trend in time, but they also had a heterogeneity and fluctuation in spatial distribution, providing a direction for the new development or management pattern of cultivated land, and (c) results on the multifunctional evaluation and tradeoff synergy relationship of cultivated land provided the foundation for determining the short‐board function and upgrading direction of cultivated land. At the grid scale, the evolution of functional distribution characteristics and functional relationships are helpful for decision‐makers to implement accurately farmland protection policies and formulate farmland regulation rules.
Aza‐Michael Addition Chemistry for Tuning the Phase Separation of PDMS/PEG Blend Coatings and Their Anti‐Fouling Potentials
Authors: Gu Yunjiao , Zhou Shuxue , Yang Jinlong 
Published: February 2020

AbstractFree adjustment of micro/nanophase‐separation degrees in coatings is not easily accessible, which is a big handicap in the development of phase‐separation‐related applications. Here, by utilizing the reactivity difference between two phases, a two‐step aza‐Michael addition pre‐crosslinking strategy, demonstrated by acryloxy‐terminated polydimethylsiloxane/polyethylene glycol (PEG) blend coatings, is proposed for the first time to tune microphase separation degrees, and promote compatibility of the biphasic amphiphilic polymer blends. Followed by a systematic study of the two‐step pre‐crosslinking time, surface morphologies of samples with desired phase‐separation degrees are unveiled using optical microscopy, AFM, and XPS. The wettability, and anti‐fouling properties — for example, anti‐protein and anti‐marine bacterial (Shewanella) adhesion — of these coatings are assessed. Less protein adsorption is observed on those surfaces with lower receding water contact angles. Shewanella adhesion is efficiently discouraged by the introduction of PEG segments, but the trend evolved with surface wettability and micro/nanophase structure in a complex way.
Effect of metabolosome encapsulation peptides on enzyme activity, coaggregation, incorporation, and bacterial microcompartment formation
Authors: Juodeikis Rokas , Lee Matthew J. , Mayer Matthias , Mantell Judith , Brown Ian R. , Verkade Paul , Woolfson Derek N. , Prentice Michael B. , Frank Stefanie , Warren Martin J. 
Published: February 2020

AbstractMetabolosomes, catabolic bacterial microcompartments (BMCs), are proteinaceous organelles that are associated with the breakdown of metabolites such as propanediol and ethanolamine. They are composed of an outer multicomponent protein shell that encases a specific metabolic pathway. Protein cargo found within BMCs is directed by the presence of an encapsulation peptide that appears to trigger aggregation before the formation of the outer shell. We investigated the effect of three distinct encapsulation peptides on foreign cargo in a recombinant BMC system. Our data demonstrate that these peptides cause variations in enzyme activity and protein aggregation. We observed that the level of protein aggregation generally correlates with the size of metabolosomes, while in the absence of cargo BMCs self‐assemble into smaller compartments. The results agree with a flexible model for BMC formation based around the ability of the BMC shell to associate with an aggregate formed due to the interaction of encapsulation peptides.
An Improved Model for Polyether Production from 1,3‐Propanediol
Authors: Dieu Vo Anh‐Duong , Elraghy Aly , Spence Rupert E. , McAuley Kimberley B. 
Published: February 2020

AbstractA dynamic mathematical model is developed for production of Cerenol polyether from 1,3‐propanediol in a batch reactor system. The model accounts for polycondensation reactions and side reactions in the liquid phase and for mass transfer of volatile species to the vapor. Parameters are estimated using measured liquid‐phase concentrations of monomer, oligomers, water, and end groups as well as the mass and composition of condensate collected from the overhead condenser system. The proposed model uses novel probability factors to keep the model equations relatively simple while accounting for the complex influence of superacid catalyst on reaction rates. The model is a significant advance over previous Cerenol models because it better accounts for mass‐transfer rates and for the dynamic behavior of the condenser. In addition, the proposed model accounts for the inhibitory influence of water on polycondensation kinetics due to hydration of hydroxyl ends. The model equations and parameter estimates provide a substantial improvement in fit to the data, especially for long reaction times and high catalyst levels, resulting in a 97% reduction in the value of the weighted least squared objective function compared to equations and parameters from a previous model.
Neuromuscular ultrasound for taxane peripheral neuropathy in breast cancer
Authors: Lycan Thomas W. , Hsu Fang‐Chi , Ahn Christine S. , Thomas Alexandra , Walker Francis O. , Sangueza Omar P. , Shiozawa Yusuke , Park Sun Hee , Peters Christopher M. , Romero‐Sandoval Edgar Alfonso , Melin Susan A. , Sorscher Steven , Ansley Katherine , Lesser Glenn J. , Cartwright Michael S. , Strowd Roy E. 
Published: February 2020

AbstractBackgroundOur study aim was to evaluate neuromuscular ultrasound (NMUS) for the assessment of taxane chemotherapy‐induced peripheral neuropathy (CIPN), the dose‐limiting toxicity of this agent.MethodsThis cross‐sectional study of breast cancer patients with taxane CIPN measured nerve cross‐sectional area (CSA) by NMUS and compared with healthy historical controls. Correlations were determined between CSA and symptom scale, nerve conduction studies, and intraepidermal nerve fiber density (IENFD).ResultsA total of 20 participants reported moderate CIPN symptoms at a median of 3.8 months following the last taxane dose. Sural nerve CSA was 1.2 mm2 smaller than healthy controls (P ≤ .01). Older age and time since taxane were associated with smaller sural nerve CSA. For each 1 mm2 decrease in sural nerve CSA, distal IENFD decreased by 2.1 nerve/mm (R2 0.30; P = .04).ConclusionsThese data support a sensory predominant taxane neuropathy or neuronopathy and warrant future research on longitudinal NMUS assessment of CIPN.
Analysis of moth flame optimization optimized cascade proportional‐integral‐proportional‐derivative controller with filter for automatic generation control system incorporating solar thermal power plant
Authors: Acharyulu B. V. S. , Mohanty Banaja , Hota P. K. 
Published: February 2020

SummaryIn the fast developing electric power system network, ancillary services like automatic generation control (AGC) plays a vital and significant role to ensure good quality of power supply in the system. To distribute good quality of power, a hybrid AGC system along with an efficient and intelligent controller is compelled. So, in this article, a cascaded proportional‐integral (PI)‐proportional‐derivative (PD) controller with filter (PI‐PDF) is proposed as secondary controller for AGC system. A nature inspired optimization algorithm named as moth flame optimization (MFO) algorithm is employed for simultaneous optimization of controller gains. Initially, a two‐area interconnected nonreheat thermal power system is investigated. Analysis revealed that MFO‐tuned PI controller performs better than the different optimization techniques tuned PI controller for the same system and PI‐PDF controller performs better than PI controller does. Then, the study is extended to a three‐area interconnected hybrid system with proper generation rate constraint. Area‐1 consists of solar thermal‐thermal unit; area‐2 consists of thermal‐hydro unit and area‐3 thermal‐gas unit as generating sources. Performance of PI‐PDF controller is compared with classical controllers such as PI, PID, PIDF, and PI‐PD controller without filter. Result analysis divulges that MFO‐tuned PI‐PDF controller performs better than all other controllers considered in this article. Robustness of the PI‐PDF controller is evaluated using parameter variations and random load variation.
Design of pipe diameter of polyester‐ramie nonwoven lining material for pipeline rehabilitation
Authors: Fu Lisong , Zhang Shujie , Wang Rui , Fang Shu , Li Danyang , Ma Tianshuai , Zhao Xuecheng 
Published: February 2020

AbstractIn order to solve the problems of pipe diameter of polyester‐ramie nonwoven lining material used for sewage pipelines rehabilitation, the mathematical model of pipe diameter of lining material was established by using elastic mechanics method and composite piping design. The mixing ratio, the fiber web quantification and the needle‐punched density were selected to optimize the manufacturing process of polyester‐ramie nonwoven with thermal shrinkage rate and elongations at break, the results showed that the mixing ratio was 0.7, and the fiber web quantification was 600 g/m2, and the needle‐punched density was 180 thron/cm2. Under this process, the thermal shrinkage rate is 8.72%, and the elongation at break is 83%, which is close to the theoretical value, indicating that the response surface method has practical application value. Combined with the mathematical model and the optimal condition of manufacturing process, the design extremum of pipe diameter of lining material for sewage pipelines with different pipe diameters is predicted, which provides the theoretical basis for the preparation of polyester‐ramie nonwoven composites for pipeline rehabilitation.
Influence of Water on the Recovery of Lube Oil Dewaxing Solvent Using P84 Polyimide Membrane: A Combination of Experiment and Molecular Simulation
Authors: Xin Yishuang , Yin Fengxiang 
Published: February 2020

AbstractWater in lube oil solution will affect the result of dewaxing solvent recovery by membrane. Three factors that affect the permeation of solvent molecules through P84 membrane and the interaction between water and dewaxing solvent were studied by combination of density functional theory (DFT) method, molecular dynamics (MD) and grand canonical Monte Carlo (GCMC) simulation. The results suggested that there is a stronger interaction between water and butanone than interactions between other molecules in dewaxing solvent. With the increase of water content in dewaxing solvent, the diffusion rate of dewaxing solvent to the membrane surface decreased, the number of butanone molecules adsorbed on the membrane surface increased slightly. However, both the total number of dewaxing solvent adsorbed and the diffusion rate of that in the membrane material decreased. In other words, the strong interaction between water and butanone reduces the penetration rate of dewaxing solvent through the membrane, which explains the experimental results. These results will be helpful for understanding of the membrane separation process deeply, and designing the membrane separation process.
Towards NIR‐Active Hydroxybenzazole (HBX)‐Based ESIPT Motifs: A Recent Research Trend
Authors: Mishra Virendra R. , Ghanavatkar Chaitannya W. , Sekar Nagaiyan 
Published: February 2020

AbstractIn this review, we have explored the synthetic strategies adopted for designing the hydroxybenzazoles (imidazole, oxazole, and thiazole) i. e. HBX derivatives which show emission in red and NIR region. Further, we have examined the effect of different substituents i. e. either directly attached or with extended conjugation on a phenolic ring/ phenyl ring of heterocycles to achieve a red to NIR shift in emission. Finally, we have investigated the applications and computational methodologies adopted for red to NIR emitting dyes. In the future, this review will help to design, synthesized and examine the applications of new derivatives of HBX which will show emission in red to NIR region.
Detergent‐Assisted Braking of Peptide Translocation through a Single‐Layer Molybdenum Disulfide Nanopore
Authors: Si Wei , Sun Qianyi , Chen Chang , Yu Meng , Sha Jingjie , Zhang Yin , Kan Yajing , Chen Yunfei 
Published: February 2020

AbstractProtein sequencing holds the key to unveiling protein dynamics, which is significant for molecular diagnostics and drug design. Single‐molecule sensing based on 2D nanopores is a versatile technique for realizing low‐cost and high‐throughput protein sequencing targets. However, the remaining challenge is that protein translocates rapidly through nanopores, where few current signals can be gathered for accurate protein sequencing. It is theoretically found that adding nonionic detergents to a solution can slow protein molecules by almost one order when they permeate through a 1.4 nm MoS2 nanopore that is slightly larger than the diameter of the peptide but smaller than the diameter of the protein–detergent complex. This slowdown is due to the strong interaction between the hydrophobic parts of the peptide and detergents. Although detergent molecules are added to the system, ionic current blockade levels can be observed for different residues, indicating that the nonionic detergents are excellent candidates for controlling protein translocation process but do not affect the discrimination of single amino acids. This theoretical work motivates experimental efforts in this area and paves a new way for protein manipulation that brings the nanopore technique closer to satisfying the requirement of high‐precision nanopore protein sequencing.
Constitutive activity of a G protein-coupled receptor, DRD1, contributes to human cerebral organoid formation
Authors: Wang Qinying , Dong Xiaoxu , Lu Jing , Hu Tingting , Pei Gang 
Published: February 2020

Abstract
The intricate balance of neural stem cell (NSC) amplification and neurogenesis is central to nervous system development. Dopamine D1 receptor (DRD1) is a typical G protein-coupled receptor (GPCR) mainly expressed in neurogenic area, with high constitutive activity. The receptor appears in the embryonic period before the formation of mature synaptic contacts, which indicates that dopamine receptor and its constitutive activity play crucial roles in the embryonic brain development. Here, we found that DRD1 was enriched in human NSCs. Inhibition of the receptor activity by its inverse agonists promoted human NSCs proliferation and impeded its differentiation. These results were also mimicked by genetic knockdown of DRD1, which also blocked the effects of inverse agonists, suggesting a receptor-dependent manner. More interestingly, knock-in A229T mutant with reduced DRD1 constitutive activity by CRISPR-Cas9 genome editing technology resulted into increased endogenous human NSCs proliferation. These results were well reproduced in human cerebral organoids, and inhibition of the DRD1 constitutive activity by its inverse agonists induced the expansion and folding of human cerebral organoids. The anatomic analysis uncovered that decreasing the constitutive activity of DRD1 by its inverse agonists promoted the NSCs proliferation and maintenance that led to hindered cortical neurogenesis. Further mechanistic studies revealed that the PKC-CBP pathway was involved in the regulation by DRD1. Thus, our findings indicate that the constitutive activity of DRD1 and possibly other GPCRs plays an important role in the development of human nervous system.
Discharge path observation and the statistical characteristics of discharge paths for long–air gap discharge for in‐operation wind turbines
Authors: Wen Xishan , Deng Yeqiang , Wang Yu , Lan Lei , Qu Lu , Wang Jian , Zhang Tao , Wang Huayun 
Published: February 2020

AbstractWhen a wind turbine is in normal operation, the blades are rotating, and this blade rotation may affect the process of lightning striking the wind turbine. To investigate this problem, long‐gap discharge tests are performed in this study. Moreover, a multiple physical parameter synchronous observation platform is designed for a scaled wind turbine. Long‐gap discharge tests of a static and rotary‐scaled wind turbine with blade tip‐electrode gap distances of 1 to 8 m are conducted, and the discharge paths under different gaps and wind turbine operating conditions are obtained. The characteristic parameters—arc shape upon discharge, lengths of the downward and upward leaders, blade angle at the moment of discharge, and angle of upward leader initiation—are statistically analyzed. The analysis of the aforementioned data indicates that rotation has opposite effects on the discharge characteristic parameters under short and long gap distances. According to the analysis, blade rotation reduces the space charge density of the corona discharge near the tip, which leads to an increase in the field strength near the blade tip and a decrease in the field strength away from the blade tip. Short and long gaps have different degrees of influence on discharge, which changes the difficulty of upward leader initiation at the blade tip and consequently alters the entire discharge process. The obtained results can provide a reference for the lightning protection of wind turbines.
Antiemetic prophylaxis with fosaprepitant and granisetron in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation
Authors: Cabanillas Stanchi Karin Melanie , Vek Julia , Schlegel Patrick , Rupprecht Joachim Vincent , Flaadt Tim , Weber Simone , Michaelis Sebastian , Lang Peter , Handgretinger Rupert , Döring Michaela 
Published: February 2020

Abstract
Background

Chemotherapy-induced nausea and vomiting (CINV) is a severe and distressing complication during allogeneic hematopoietic stem cell transplantation (alloHSCT). The antiemetic fosaprepitant has shown favorable results in pediatric and adult patients receiving chemotherapy. Data on fosaprepitant in children and adolescents undergoing alloHSCT are missing.

Methods
In this non-interventional observation study, 120 children and adolescents with a median age of 11.8 years undergoing alloHSCT after a moderately or highly emetogenic conditioning (MEC or HEC) were analyzed. They received an antiemetic prophylaxis with granisetron (2 × 40 µg/kg d−1) with or without fosaprepitant (4 mg/kg; single dose, max. 1 × 150 mg/kg BW), and were analyzed in the control (CG; n = 60) or fosaprepitant group (FG; n = 60). The efficacy and safety of the two antiemetic prophylaxis regimens were analyzed and compared with respect to the acute (0–24 h) and the delayed (> 24–120 h) CINV phase and > 120–240 h after MEC or HEC administration.

Results
During MEC, significantly more patients in the CG experienced vomiting during the first 0–24 h (58.6 vs. 25.0%; p = 0.0156) and during > 24–120 h (93.1% vs. 57.1%; p = 0.0020), compared with the FG. Likewise, significantly more vomiting events (269 vs. 136; p < 0.0001) were registered in the CG. During HEC, significantly more patients in the CG experienced vomiting during the first 0–24 h (32.3 vs. 9.4%; p = 0.0319) compared with the FG. Significantly more vomiting events (241 vs. 99; p < 0.0001) were registered in the CG. Laboratory and clinical adverse events were not significantly different between the two groups (p > 0.05).

Conclusions
Antiemetic prophylaxis with fosaprepitant and granisetron was well tolerated, safe, and effective in pediatric patients undergoing alloHSCT. However, larger prospective trials are necessary to evaluate these findings.
Co-cultures with integrated in situ product removal for lactate-based propionic acid production
Authors: Selder Ludwig , Sabra Wael , Jürgensen Nikolai , Lakshmanan Alagappan , Zeng An-Ping 
Published: February 2020

AbstractPropionic acid (PA) is a valuable organic acid for the food and feed industry, but no bioproduction at industrial scale exists so far. As product inhibition is a major burden for bioprocesses producing organic acids, in situ product removal (ISPR) is desirable. Here, we demonstrate a new strategy to produce PA with a co-culture coupled with ISPR using electrodialysis. Specifically, Bacillus coagulans first produces lactic acid (LA) from sugar(s) and LA is converted to PA using Veillonella criceti. Applying ISPR to the mentioned co-culture, the specific PA yield was increased from 0.35 to 0.39 g g−1 compared to no ISPR usage. Furthermore, the productivity was increased from 0.63 to 0.7 g L−1 h−1 by applying ISPR. Additionally, it was shown that co-consumption of xylose and glucose led to a higher PA productivity of 0.73 g L−1 h−1, although PA yield was only increased slightly up to 0.36 g g−1.