bluuebunny/crossref_metadata_2025_split huggingface dataset:
Addition of Androgen-Deprivation Therapy or Brachytherapy Boost to External Beam Radiotherapy for Localized Prostate Cancer: A Network Meta-Analysis of Randomized Trials
Authors: Jackson William C. , Hartman Holly E. , Dess Robert T. , Birer Sam R. , Soni Payal D. , Hearn Jason W.D. , Reichert Zachary R. , Kishan Amar U. , Mahal Brandon A. , Zumsteg Zachary S. , Efstathiou Jason A. , Kaffenberger Samuel , Morgan Todd M. , Mehra Rohit , Showalter Timothy N. , Krauss Daniel A. , Nguyen Paul L. , Schipper Matthew J. , Feng Felix Y. , Sandler Howard M. , Hoskin Peter J. , Roach Mack , Spratt Daniel E. 
Published: May 2020

PURPOSE In men with localized prostate cancer, the addition of androgen-deprivation therapy (ADT) or a brachytherapy boost (BT) to external beam radiotherapy (EBRT) have been shown to improve various oncologic end points. Practice patterns indicate that those who receive BT are significantly less likely to receive ADT, and thus we sought to perform a network meta-analysis to compare the predicted outcomes of a randomized trial of EBRT plus ADT versus EBRT plus BT. MATERIALS AND METHODS A systematic review identified published randomized trials comparing EBRT with or without ADT, or EBRT (with or without ADT) with or without BT, that reported on overall survival (OS). Standard fixed-effects meta-analyses were performed for each comparison, and a meta-regression was conducted to adjust for use and duration of ADT. Network meta-analyses were performed to compare EBRT plus ADT versus EBRT plus BT. Bayesian analyses were also performed, and a rank was assigned to each treatment after Markov Chain Monte Carlo analyses to create a surface under the cumulative ranking curve. RESULTS Six trials compared EBRT with or without ADT (n = 4,663), and 3 compared EBRT with or without BT (n = 718). The addition of ADT to EBRT improved OS (hazard ratio [HR], 0.71 [95% CI, 0.62 to 0.81]), whereas the addition of BT did not significantly improve OS (HR, 1.03 [95% CI, 0.78 to 1.36]). In a network meta-analysis, EBRT plus ADT had improved OS compared with EBRT plus BT (HR, 0.68 [95% CI, 0.52 to 0.89]). Bayesian modeling demonstrated an 88% probability that EBRT plus ADT resulted in superior OS compared with EBRT plus BT. CONCLUSION Our findings suggest that current practice patterns of omitting ADT with EBRT plus BT may result in inferior OS compared with EBRT plus ADT in men with intermediate- and high-risk prostate cancer. ADT for these men should remain a critical component of treatment regardless of radiotherapy delivery method until randomized evidence demonstrates otherwise.
Higher TSH Is Not Associated With Thyroid Cancer Risk in the Presence of Thyroid Autoimmunity
Authors: Paparodis Rodis D , Bantouna Dimitra , Karvounis Evangelos , Imam Shahnawaz , Jaume Juan Carlos 
Published: May 2020

Abstract

Background
Higher-but-within-normal thyrotropin (thyroid-stimulating hormone, TSH) is associated with higher risk for differentiated thyroid cancer (DTC) in surgical series. Our recent clinical observations suggest that this is not the case in the presence of autoimmune thyroid disease (AITD). We designed the present study to clarify this controversy.

Methods
We analyzed our prospectively collected database of patients referred for thyroid surgery at 2 tertiary care referral centers in Greece and the United States. We collected data for preoperative TSH, postoperative pathology, and thyroid peroxidase (TPO) antibodies titers. Subjects were subdivided into 2 groups, those with AITD (i.e., lymphocytic thyroiditis) and non-AITD. We excluded subjects with Graves disease, abnormal TSH (&lt; 0.40 or &gt; 4.50 mIU/mL), or recent use of levothyroxine. We compared the serum TSH among different groups using the Mann-Whitney test.

Results
A total of 3973 subjects were screened; 1357 met exclusion criteria. After all exclusions, data from 1731 non-AITD subjects and 329 AITD subjects were included in the analysis. AITD subjects had higher TSH than non-AITD subjects (2.09 vs 1.48; P &lt; 0.0001). TSH values were higher in DTC compared with benign histology only in non-AITD subjects (1.65 vs 1.40; P &lt; 0.0001). Progressively higher TSH was associated with higher incidence of DTC only in non-AITD subjects (P &lt; 0.0001). In AITD subjects, TSH was similar between groups with or without DTC (2.02 vs 2.14; P = 0.21).

Conclusions
TSH concentrations are not associated with the risk of developing DTC in the presence of thyroid autoimmunity, even though this seems to be the case for all other patients.
Efficient genome editing by CRISPR-Mb3Cas12a in mice
Authors: Wang Zhuqing , Wang Yue , Wang Shawn , Gorzalski Andrew J. , McSwiggin Hayden , Yu Tian , Castaneda-Garcia Kimberly , Prince Brian , Wang Hetan , Zheng Huili , Yan Wei 
Published: May 2020

ABSTRACT
As an alternative and complementary approach to Cas9-based genome editing, Cas12a has not been widely used in mammalian cells largely due to its strict requirement for the TTTV protospacer adjacent motif (PAM) sequence. Here, we report that Mb3Cas12a (Moraxella bovoculi AAX11_00205) can efficiently edit the mouse genome based on the TTV PAM sequence with minimal numbers of large on-target deletions or insertions. When TTTV PAM sequence-targeting CRISPR (cr)RNAs of 23 nt spacers are used, &gt;70% of the founders obtained are edited. Moreover, the use of Mb3Cas12a tagged to monomeric streptavidin (mSA) in conjunction with biotinylated DNA donor template leads to high knock-in efficiency in two-cell mouse embryos, with 40% of founders obtained containing the desired knock-in sequences.
The flipside of the TOR coin – TORC2 and plasma membrane homeostasis at a glance
Authors: Riggi Margot , Kusmider Beata , Loewith Robbie 
Published: May 2020

ABSTRACT
Target of rapamycin (TOR) is a serine/threonine protein kinase conserved in most eukaryote organisms. TOR assembles into two multiprotein complexes (TORC1 and TORC2), which function as regulators of cellular growth and homeostasis by serving as direct transducers of extracellular biotic and abiotic signals, and, through their participation in intrinsic feedback loops, respectively. TORC1, the better-studied complex, is mainly involved in cell volume homeostasis through regulating accumulation of proteins and other macromolecules, while the functions of the lesser-studied TORC2 are only now starting to emerge. In this Cell Science at a Glance article and accompanying poster, we aim to highlight recent advances in our understanding of TORC2 signalling, particularly those derived from studies in yeast wherein TORC2 has emerged as a major regulator of cell surface homeostasis.
Metformin improves FOXP3 mRNA expression through suppression of interferon gamma levels in pristane-induced murine models of lupus
Authors: Sumantri Stevent , Hatta Mochammad , Natzir Rosdiana , Rasyid Haerani , Rengganis Iris , Massi Muhammad Nasrum , Islam Andi Asadul , Lawrence Gatot , Patellongi Ilhamjaya , Benyamin Andi Fachruddin 
Published: May 2020

Background: A recent study has indicated the potential of metformin therapy for lupus in animal models, but there has been no study evaluating the effect on pristane-induced lupus. This study aims to evaluate the effect of intraperitoneal versus oral metformin on interferon (IFN)-γ levels and FOXP3 mRNA expression on pristane-induced female BALB/c mice. Methods: In total, 31 female BALB/c mice, aged 6 weeks, were intraperitoneally induced with 0.5 ml of pristane (2,6,10,14-tetramethylpentadecane). After 120 days, the mice were grouped and treated with various treatments: normal saline 100 mcl, oral metformin 100mg/kgBW, or intraperitoneal metformin 100mg/kgBW. After 60 days of treatment, all treatment groups were sacrificed, and kidney specimens prepared and stained using hematoxylin and esosin. Results: IFNγ levels of saline controls vs. oral metformin group was 309.39 vs. 292.83 pg/mL (mean difference 16.56 pg/mL; 95% CI 0.74-32.37; p=0.042), and saline control vs. intraperitoneal metformin group was 309.39 vs. 266.90 pg/mL (mean difference 42.49 pg/mL; 95% CI 29.24-55.73 pg/mL; p<0.004). FOXP3 mRNA expression changes in saline controls vs. oral metformin group was 6.90 vs. 7.79-fold change (mean difference -0.89-fold change; 95% CI -1.68-(-0.11); p=0.03) and in saline controls vs. intraperitoneal metformin group was 6.90 vs. 9.02-fold change (mean difference -2.12-fold change; 95% CI -2.99-(-1.25); p=<0.001). Correlation analysis of FOXP3 mRNA expression and IFNγ level changes revealed a Pearson correlation of -0.785 (p=0.001) and R2 value of 0.616 (p=0.001). Conclusion: Metformin is a potential new therapy to reduce the levels of IFNγ and increase FOXP3 mRNA expression in mice models of systemic lupus erythematosus. Intraperitoneal metformin, i.e intravenous administration in human, could provide a novel route of administration to improve the effect of metformin for lupus patients.
School closure in response to epidemic outbreaks: Systems-based logic model of downstream impacts
Authors: Kneale Dylan , O'Mara-Eves Alison , Rees Rebecca , Thomas James 
Published: May 2020

Background:School closures have been a recommended non-pharmaceutical intervention in pandemic response owing to the potential to reduce transmission of infection between children, school staff and those that they contact. However, given the many roles that schools play in society, closure for any extended period is likely to have additional impacts. Literature reviews of research exploring school closure to date have focused upon epidemiological effects; there is an unmet need for research that considers the multiplicity of potential impacts of school closures.Methods:We used systematic searching, coding and synthesis techniques to develop a systems-based logic model. We included literature related to school closure planned in response to epidemics large and small, spanning the 1918-19 ‘flu pandemic through to the emerging literature on the 2019 novel coronavirus. We used over 170 research studies and a number of policy documents to inform our model.Results:The model organises the concepts used by authors into seven higher level domains: children’s health and wellbeing, children’s education, impacts on teachers and other school staff, the school organisation, considerations for parents and families, public health considerations, and broader economic impacts. The model also collates ideas about potential moderating factors and ethical considerations. While dependent upon the nature of epidemics experienced to date, we aim for the model to provide a starting point for theorising about school closures in general, and as part of a wider system that is influenced by contextual and population factors.Conclusions:The model highlights that the impacts of school closures are much broader than those related solely to health, and demonstrates that there is a need for further concerted work in this area. The publication of this logic model should help to frame future research in this area and aid decision-makers when considering future school closure policy and possible mitigation strategies.
Integrated Navigation Models of a Mobile Fodder-Pushing Robot Based on a Standardized Cow Husbandry Environment
Authors: Yang Shenghui , Liang Shenghao , Zheng Yongjun , Tan Yu , Xiao Zhang , Li Baosheng , Liu Xingxing 
Published: May 2020

HighlighIntegrated navigation models for a two-wheel robot were specifically developed for a semi-enclosed environment.A combination of Kalman filter and fuzzy control system was developed with mathematical models.Real-time pose estimate and adjustment of perturbances due to feeding cows and fodder resistance were achieved.Abstract. As part of welfare feeding, standardized feeding is commonly used for cows in confined operations. Due to the strict facility requirements, smart mobile robots have been specifically developed to address these semi-enclosed environments. Their navigation is based on electromagnetic sensors with magnetic tapes, which does not easily allow route changes and other abilities afforded by the newer integrated sensors and Global Navigation Satellite System (GNSS) guidance packages available on large agricultural machinery in outdoor environments. This article proposes a system of integrated navigation using multiple sensors, which was used for a two-wheel-drive robot operating in the standardized environment of a cow husbandry facility. The developed system combined incremental encoders, ultrasonic sensors, and a gyroscope to determine parameters such as course angle and covered distance. A fuzzy self-adaption Kalman filter was applied to integrate these parameters and estimate the robot pose, so that the robot could achieve real-time course adjustment during operation. Experimental trials indicated that the real-world route was highly consistent with the set route. Moreover, the cross-track error was =0.10 m at a travel velocity of 0.2 m s-1, indicating that perturbances due to feeding cows and fodder resistance had little interference on the movement of the robot, and the models were robust and accurate. This novel integrated sensing system with a fuzzy self-adaption Kalman filter and derived models was able to guide real-time robot operations in a modern cow husbandry environment without the need for magnetic tapes. Keywords: Kalman filter, Integrated navigation, Motion models, Pose estimate, Welfare feeding.
Characterization and Detection of Leaf Photosynthetic Response to Citrus Huanglongbing from Cool to Hot Seasons in Two Orchards
Authors: Weng Haiyong , Zeng Yibing , Cen Haiyan , He Mubin , Meng Youqing , Liu Yu , Wan Liang , Xu Haixia , Li Hongye , Fang Hui , He Yong 
Published: May 2020

HighlightsAn abnormal accumulation of sucrose and glucose was found in HLB-infected leaves, and it presented a similar pattern in different orchards from cool to hot seasons.A decreasing value of the actual quantum yield of PSII (FPSII) in HLB-infected leaves was mainly related to an increase of non-regulated energy quenching (FNO) due to the irreversible damage of PSII.Chlorophyll fluorescence imaging combined with a random forest was able to identify HLB at the asymptomatic stage.Abstract Citrus Huanglongbing (HLB) poses a serious threat to citrus production. This research aimed to explore chlorophyll fluorescence imaging for characterizing the photosynthetic response to HLB-infected citrus leaves in different orchards and seasons. Chlorophyll fluorescence images of citrus leaves were acquired with an in-house chlorophyll fluorescence imaging system. It was found that sucrose and glucose accumulated earlier than starch in HLB-infected leaves, and a similar carbohydrate metabolic pattern was observed in HLB-infected leaves grown in different orchards from cool to hot seasons. The pathogen damaged the thylakoid structure of chloroplasts with a higher value of Fo. It decreased photosynthetic activity of the host by reducing the number of active photosynthetic centers and the maximum quantum yield of PSII (Fv/Fm) with lower values of Fv/Fo and Fv/Fm. Additionally, the pathogen modified the allocation of excitation energy in citrus leaves by reducing the actual quantum yield of PSII (FPSII) due to an increase of non-regulated energy quenching (FNO), which indicated irreversible PSII damage before symptom development. Moreover, photosynthetic signatures combined with the random forest method were able to identify HLB in the asymptomatic stage with an overall accuracy of 91.8%. These results demonstrated the potential of chlorophyll fluorescence imaging for evaluating the photosynthetic response to HLB as well as disease diagnosis. Keywords: Carbohydrate metabolism, Chlorophyll fluorescence imaging, Citrus Huanglongbing, Photosynthetic efficiency, Random forest model.
Purification and Identification of Antioxidant Peptides from Hydrolysates of Large Yellow Croaker (Pseudosciaena crocea) Scales
Authors: Chen Wenwei , Hong Yao , Jia Zhenbao , Huang Guangrong 
Published: May 2020

HighlightsThree antioxidant peptides were efficiently obtained from large yellow croaker scales.The molecular weights of the three peptides were 879.4, 952.5, and 1070.4 Da, respectively.The large yellow croaker scales’ hydrolysates are a good source of natural antioxidants.Abstract. The scales of large yellow croaker () are typically discarded as waste during processing. In this study, three peptides with high antioxidant properties were purified from the scales via ultrafiltration and column chromatography. Through matrix-assisted laser desorption ionization/time-of-flight mass spectrometry, the sequences of the three peptides were identified as Gln-Arg-Pro-Pro-Glu-Pro-Arg (M1N4-1, 879.4 Da), Glu-Lys-Val-Trp-Lys-Tyr-Cys-Asp (M1N4-2, 1070.4 Da), and Val-Gly-Leu-Pro-Gly-Leu-Ser-Gly-Pro-Val-Gly (M2N2-1, 952.5 Da). The antioxidant activity of the peptides was directly determined through 1-diphenyl-2-picrylhydrazyl scavenging assay. Results suggested that large yellow croaker scales are a good source of natural antioxidants. Keywords: Antioxidant peptide, Hydrolysis, Pseudosciaena crocea, Scale.
Research on terahertz transmission characteristics of nonpolar liquid based on frequency-domain spectroscopy
Authors: Guo Su-jie , Ruan Cun-jun , Kong De-yin , Dai Jun , Zhang Yan , He Wen-long 
Published: May 2020

In our research, terahertz frequency-domain spectroscopy based on continuous-wave and coherent detection, which offers advantages of frequency selectivity and much higher frequency resolution, is used to acquire the optical parameter of nonpolar liquid samples in a polytetrafluoroethylene (PTFE) rectangle cell. The transfer matrix method is raised to remove the oscillation generated by the Fabry–Perot interferometer caused by the cell wall; thereby, dielectric constants of liquids can be extracted successfully. The refractive index of the nonpolar liquid samples cyclohexane (

C

6

H

12

)

and

n

-Hexane (

C

6

H

14

) are obtained within the frequency range of 400–1600 GHz. The processed results of cyclohexane and n-Hexane in our method are basically stable with a refractive index of about 1.42 and 1.37, respectively, which agrees well with the experimental results using other methods previously.
RESÚMENES DE TESIS: MAESTRÍA EN DIDÁCTICA DE LAS CIENCIAS EXPERIMENTALES
Authors: Collins Pablo Agustín 
Published: May 2020

Los contenidos actitudinales en la trama formativa de los residentes del Profesorado de Biología y su implementación en las prácticas áulicasMónica Francisca Eceiza - monicaeceiza@hotmail.comDirector: Dr. Aníbal BarLugar de realización: Villa Ángela, ChacoFecha de defensa: 30 de mayo de 2018

Incidencia del uso de un entorno tecnológico presencial-virtual en los procesos de enseñanza y aprendizaje. Desarrollo de una experiencia en el Profesorado de BiologíaMaría Rosa Venezia - veneziamariarosa@gmail.comDirectora: Dra. Ana Patricia FabroCo-Directora: Dra. María del Rosario de la RiestraLugar de realización: ISPI No 9028 “Ntra. Sra. del Huerto”. Nivel Superior. Profesorado para la Educación Secundaria en Biología. Rosa-rio. Provincia de Santa Fe. ArgentinaFecha de defensa: 28 de marzo de 2018
PEMIMPIN RUMAH TANGGA DALAM TAFSIR (Kaji Ulang Pendapat Feminis dengan Metode Ta’wīl)
Authors: Dedi Syarial 
Published: May 2020

This paper aims to explain the opinion of some traditionalist Muslim scholars who refute feminist opinions of verse 34 of an-Nisā’ about household leaders. This study takes the form of a library with the content analysis method. Utilizing qawāʿid al-lughawi'ah (linguistic rules) like the ta'wīl method which is inherited uṣūliyyīn (Islamic law expert, scholars such as Rasyīd Riḍā ‘Alī aṣ-Ṣābūnī, and aṭ-Ṭabāṭabāʿī argued that men are more superior than women in some aspect such as intellectual. Therefore, it is men who have a duty to become the leader. Tulisan ini menjelaskan tentang pendapat beberapa sarjana Muslim tradisional yang menolak pendapat kaum feminist tentang kesejajaran laki-laki dan perempuan dalam menafsirkan surat Nisā’ ayat 34. Dengan menggunakan data literer dan analisis isi, tulisan ini menunjukkan bahwa beberapa sarjana Muslim Rasyīd Riḍā ‘Alī aṣ-Ṣābūnī, and aṭ-Ṭabāṭabāʿī berpendapat bahwa laki-laki berbeda dengan perempuan. Laki-laki mempunyai kemampuan intelektual lebih dibandingkan dengan perempuan. Oleh karena itu, maka kepemimpinan ada di punggung laki-laki.
THE EFFECT OF ANGER MANAGEMENT TRAINING TOWARD AGGRESSIVE BEHAVIOR IN ADOLESCENTS
Authors: Farisandy Ellyana Dwi , Hartini Nurul 
Published: May 2020

The purpose of this study is to examine the effect of anger management training on adolescent aggression behavior. This study uses a quasi-experimental method, with one group pretest-posttest design. The treatment is only given to one group. The population of this study is 15 male neglected and street adolescences. The subjects of this study were six male adolescences (Mage = 14 years old, SD =.75), with highly aggressive behavior. Aggression behavior is measured using the CBCL (Child Behavior Checklist). The adolescence who have scores above the threshold line are then involved in this study. Data were collected before and after the intervention using the Aggression Questionnaire (AQ) (29 items, α = .917). As a treatment, a nine-session of anger management training was conducted. The data was analyzed with the Wilcoxon signed-rank test, and the result shows that there is a significant difference knowledge before and after training (p = .028, p <.05). Posttest scores were better than pretest scores. It can be concluded that anger management training can be considered as a good program in increasing knowledge about aggression and procedure in reducing aggressive behavior.
Laboratory predictors of death from coronavirus disease 2019 (COVID-19) in the area of Valcamonica, Italy
Authors: Bonetti Graziella , Manelli Filippo , Patroni Andrea , Bettinardi Alessandra , Borrelli Gianluca , Fiordalisi Gianfranco , Marino Antonio , Menolfi Annamaria , Saggini Sara , Volpi Roberta , Anesi Adriano , Lippi Giuseppe 
Published: May 2020

Abstract

Background
Comprehensive information has been published on laboratory tests which may predict worse outcome in Asian populations with coronavirus disease 2019 (COVID-19). The aim of this study is to describe laboratory findings in a group of Italian COVID-19 patients in the area of Valcamonica, and correlate abnormalities with disease severity.

Methods
The final study population consisted of 144 patients diagnosed with COVID-19 (70 who died during hospital stay and 74 who survived and could be discharged) between March 1 and 30, 2020, in Valcamonica Hospital. Demographical, clinical and laboratory data were collected upon hospital admission and were then correlated with outcome (i.e. in-hospital death vs. discharge).

Results
Compared to patients who could be finally discharged, those who died during hospital stay displayed significantly higher values of serum glucose, aspartate aminotransferase (AST), creatine kinase (CK), lactate dehydrogenase (LDH), urea, creatinine, high-sensitivity cardiac troponin I (hscTnI), prothrombin time/international normalized ratio (PT/INR), activated partial thromboplastin time (APTT), D-dimer, C reactive protein (CRP), ferritin and leukocytes (especially neutrophils), whilst values of albumin, hemoglobin and lymphocytes were significantly decreased. In multiple regression analysis, LDH, CRP, neutrophils, lymphocytes, albumin, APTT and age remained significant predictors of in-hospital death. A regression model incorporating these variables explained 80% of overall variance of in-hospital death.

Conclusions
The most important laboratory abnormalities described here in a subset of European COVID-19 patients residing in Valcamonica are highly predictive of in-hospital death and may be useful for guiding risk assessment and clinical decision-making.