bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical modification of melphalan as a key to improving treatment of haematological malignancies
Authors: Gajek Arkadiusz , Poczta Anastazja , Łukawska Małgorzata , Cecuda- Adamczewska Violetta , Tobiasz Joanna , Marczak Agnieszka 
Published: March 2020

AbstractChemical modification of known, effective drugs is one method to improve chemotherapy. Thus, the object of this study was to generate melphalan derivatives with improved cytotoxic activity in human cancer cells (RPMI8226, HL60 and THP1). Several melphalan derivatives were synthesised, modified in their two important functional groups. Nine analogues were tested, including melphalan compounds modified: only at the amino group, by replacing the amine with an amidine group containing a morpholine ring (MOR-MEL) or with an amidino group and dipropyl chain (DIPR-MEL); only at the carboxyl group to form methyl and ethyl esters of melphalan (EM-MEL, EE-MEL); and in a similar manner at both functional groups (EM-MOR-MEL, EE-MOR-MEL, EM-DIPR-MEL, EE-DIPR-MEL). Melphalan derivatives were evaluated for cytotoxicity (resazurin viability assay), genotoxicity (comet assay) and the ability to induce apoptosis (terminal deoxynucleotidyl transferase dUTP nick end labelling, TUNEL, phosphatidylserine externalisation, chromatin condensation, activity of caspases 3/7, 8 and 9 and intracellular concentration of calcium ions) in comparison with the parent drug. Almost all derivatives, with the exception of MOR-MEL and DIPR-MEL, were found to be more toxic than melphalan in all cell lines evaluated. Treatment of cultures with the derivatives generated a significant higher level of DNA breaks compared to those treated with melphalan, especially after longer incubation times. In addition, all the melphalan derivatives demonstrated a high apoptosis-inducing ability in acute monocytic and promyelocytic leukemia cells. This study showed that the mechanism of action of the tested compounds differed depending on the cell line, and allowed the selection of the most active compounds for further, more detailed investigations.
Comparison of Quantitative light-induced fluorescence-digital (QLF-D) images and images of disclosed plaque for planimetric quantification of dental plaque in multibracket appliance patients
Authors: Klaus Katharina , Glanz Tabea , Glanz Alexander Georg , Ganss Carolina , Ruf Sabine 
Published: March 2020

AbstractThe purpose of the present cross-sectional clinical study was to check the ability of plaque detection and quantification by QLF-D against conventional digital photographs of disclosed plaque in multibracket appliance (MB) patients. 20 patients were included according to the following criteria: (1) upper and lower jaw treated by MB appliance, (2) patients being 16 years of age or older, (3) all central and lateral incisors as well as canines in situ, (4) absence of developmental defects, carious lesions, surface fillings, prosthetic restorations or recessions greater than 1/3 of root length in central/lateral incisors and canines as well as (5) declaration of consent. QLF-D and conventional photographs were analyzed planimetrically regarding plaque coverage on buccal and oral surfaces of central/lateral incisors and canines. The conventional photographs of stained plaque served as gold standard. On average, in QLF-D pictures 20.7% ± 17.4 of the tooth surfaces were covered with plaque, while the conventional photographs of disclosed plaque presented a mean plaque-covered area of 36.2% ± 23.5. The Bland-Altman plot for both imaging modalities showed a very large inconsistent scattering with both negative and positive deviations. The method discrepancy increased with increasing plaque coverage, thus indicating a systematic method error. On average, the deviation of the methods from the optimal line of accordance was −15.5%. In patients wearing MB appliances, there was no clinical significant agreement regarding the plaque-covered tooth surface depicted by QLF-D respectively conventional images of disclosed plaque. Due to the large method discrepancy, QLF-D is currently not reliable for precise plaque quantification in MB patients.
Development of an intelligent CAD system for mass detection in mammographic images
Authors: Andreadis Theofilos , Emmanouilidis Christodoulos , Goumas Stefanos , Koulouriotis Dimitrios 
Published: March 2020

Mammography is a very useful tool to diagnose breast cancer in early stages when it is easier to treat. There are two types of evidence that radiologists look for in a mammogram, calcifications and the existence of masses. In this study, an intelligent computer‐aided diagnosis system is proposed for the detection of masses in mammographic images regardless of their nature. The proposed method uses a combination of extended maxima transformations, having different threshold values, in order to find suitable internal and external markers for a marker‐based watershed segmentation. After segmentation, a two‐stage classifier is used to distinguish the masses better from the healthy breast tissue. A feature vector based mainly on contrast and texture features is calculated and two alternative approaches, a Bayesian classifier and a support vector machine (SVM) with Gaussian kernel function, are implemented for further reduction of the false positive areas. The system was evaluated using the data from two online databases. Specifically, 73 mammographic images from the new curated breast imaging subset of digital database for screening mammography (CBIS‐DDSM) database and all the mammographic images that contain masses from the mini‐mammographic image analysis society (MIAS) database were used. The overall sensitivity, in both datasets, was near 80% when the Bayesian classifier was used and above 85% when the SVM was applied.
Inflection point in the power spectrum of stellar brightness variations
Authors: Amazo-Gómez E. M. , Shapiro A. I. , Solanki S. K. , Krivova N. A. , Kopp G. , Reinhold T. , Oshagh M. , Reiners A. 
Published: March 2020

Context. Young and active stars generally have regular, almost sinusoidal, patterns of variability attributed to their rotation, while the majority of older and less active stars, including the Sun, have more complex and non-regular light curves, which do not have clear rotational-modulation signals. Consequently, the rotation periods have been successfully determined only for a small fraction of the Sun-like stars (mainly the active ones) observed by transit-based planet-hunting missions, such as CoRoT, Kepler, and TESS. This suggests that only a small fraction of such systems have been properly identified as solar-like analogues.
Aims. We aim to apply a new method of determining rotation periods of low-activity stars, such as the Sun. The method is based on calculating the gradient of the power spectrum (GPS) of stellar brightness variations and identifying a tell-tale inflection point in the spectrum. The rotation frequency is then proportional to the frequency of that inflection point. In this paper, we compare this GPS method to already-available photometric records of the Sun.
Methods. We applied GPS, auto-correlation functions, Lomb-Scargle periodograms, and wavelet analyses to the total solar irradiance (TSI) time series obtained from the Total Irradiance Monitor on the Solar Radiation and Climate Experiment and the Variability of solar IRradiance and Gravity Oscillations experiment on the SOlar and Heliospheric Observatory missions. We analysed the performance of all methods at various levels of solar activity.
Results. We show that the GPS method returns accurate values of solar rotation independently of the level of solar activity. In particular, it performs well during periods of high solar activity, when TSI variability displays an irregular pattern, and other methods fail. Furthermore, we show that the GPS and light curve skewness can give constraints on facular and spot contributions to brightness variability.
Conclusions. Our results suggest that the GPS method can successfully determine the rotational periods of stars with both regular and non-regular light curves.
Comparison of the shape and temporal evolution of even and odd solar cycles
Authors: Takalo Jouni , Mursula Kalevi 
Published: March 2020

Aims. We study the difference in the shape of solar cycles for even and odd cycles using the Wolf sunspot numbers and group sunspot numbers of solar cycles 1−23. We furthermore analyse the data of sunspot area sizes for even and odd cycles SC12−SC23 and sunspot group data for even and odd cycles SC8−SC23 to compare the temporal evolution of even and odd cycles.
Methods. We applied the principal component analysis (PCA) to sunspot cycle data and studied the first two components, which describe the average cycle shape and cycle asymmetry. We used a distribution analysis to analyse the temporal evolution of the even and odd cycles and determined the skewness and kurtosis for even and odd cycles of sunspot group data.
Results. The PCA confirms the existence of the Gnevyshev gap (GG) for solar cycles at about 40% from the start of the cycle. The temporal evolution of sunspot area data for even cycles shows that the GG exists at least at the 95% confidence level for all sizes of sunspots. On the other hand, the GG is shorter and statistically insignificant for the odd cycles of aerial sunspot data. Furthermore, the analysis of sunspot area sizes for even and odd cycles of SC12−SC23 shows that the greatest difference is at 4.2−4.6 years, where even cycles have a far smaller total area than odd cycles. The average area of the individual sunspots of even cycles is also smaller in this interval. The statistical analysis of the temporal evolution shows that northern sunspot groups maximise earlier than southern groups for even cycles, but are concurrent for odd cycles. Furthermore, the temporal distributions of odd cycles are slightly more leptokurtic than distributions of even cycles. The skewnesses are 0.37 and 0.49 and the kurtoses 2.79 and 2.94 for even and odd cycles, respectively. The correlation coefficient between skewness and kurtosis for even cycles is 0.69, and for odd cycles, it is 0.90.
Conclusions. The separate PCAs for even and odd sunspot cycles show that odd cycles are more inhomogeneous than even cycles, especially in GSN data. Even cycles, however, have two anomalous cycles: SC4 and SC6. The variation in the shape of the early sunspot cycles suggests that there are too few and/or inaccurate measurements before SC8. According to the analysis of the sunspot area size data, the GG is more distinct in even than odd cycles. This may be partly due to sunspot groups maximizing earlier in the northern than in the southern hemisphere for even cycles. We also present another Waldmeier-type rule, that is, we find a correlation between skewness and kurtosis of the sunspot group cycles.
Lipschitz continuity of the eigenfunctions on optimal sets for functionals with variable coefficients
Authors: Trey Baptiste 
Published: March 2020

This paper is dedicated to the spectral optimization problemmin{λ1(Ω)+⋯+λk(Ω)+Λ|Ω| : Ω⊂Dquasi-open}whereD⊂ ℝdis a bounded open set and 0 <λ1(Ω) ≤⋯ ≤λk(Ω) are the firstkeigenvalues onΩof an operator in divergence form with Dirichlet boundary condition and Hölder continuous coefficients. We prove that the firstkeigenfunctions on an optimal set for this problem are locally Lipschtiz continuous inDand, as a consequence, that the optimal sets are open sets. We also prove the Lipschitz continuity of vector-valued functions that are almost-minimizers of a two-phase functional with variable coefficients.
Concerns of Pregnant Women in “Prenatal
Screening/Diagnosis” Practice and Termination of
Pregnancy
Authors: Kasnakoglu Berna Tari , Cakar Mehmet , Okem Zeynep Guldem , Tanacan Atakan , Fadiloglu Erdem , Orgul Gokcen , Beksac Mehmet Sinan 
Published: March 2020

Abstract
Objective To investigate the reasons for decision-making and concerns of
patients in the field of prenatal screening, invasive prenatal diagnostic
testing (IPDT), and termination of pregnancy (TOP).
Study Design This questionnaire-based study consisted of 107 pregnant
women who were referred for prenatal screening to the Hacettepe University
Hospital. The questionnaire given to patients was prepared from scratch since
there is no standard set of questions measuring patients’ feelings and
concerns regarding prenatal screening/diagnosis, IPDT, and TOP.
Results Our questionnaire results showed that it is possible to classify
decision-making factors into 6 groups: psychological, social, fear,
religious/faith, support, and trust. The majority of patients were
undecided (48.6%) about IPDT if prenatal screening test results were
risky. Only 23.4% of patients were willing to accept IPDT. On the other
hand, 55.1% of patients were not willing to undergo TOP if the fetal
karyotyping results were abnormal. Religious factors seem to be important in
refusing IPDT and TOP.
Conclusion Physicians should re-evaluate their practice in the field of
prenatal screening and diagnosis in light of the high refusal rates of IPDT and
TOP. Understanding factors influencing womenʼs decision-making processes
provides insight for service providers to help women at high risk of having
foetal anomalies to make better-informed choices.
Nomogram to predict lymph node metastasis in patients with early gastric cancer: a useful clinical tool to reduce gastrectomy after endoscopic resection
Authors: Kim Su Mi , Min Byung-Hoon , Ahn Joong Hyun , Jung Sin-Ho , An Ji Yeong , Choi Min Gew , Sohn Tae Sung , Bae Jae Moon , Kim Sung , Lee Hyuk , Lee Jun Haeng , Kim Young Woo , Ryu Keun Won , Kim Jae J. , Lee Jun Ho 
Published: March 2020

Abstract
Background The indications for endoscopic dissection have been expanded to improve the quality of life of patients with early gastric cancer (EGC). This study aimed to develop a nomogram to predict the status of lymph node metastasis with the aim of avoiding unnecessary gastrectomies.
Methods We reviewed the clinicopathological data of 10 579 patients who underwent curative resection for EGC. The nomogram was developed by multivariate analysis and was evaluated by external validation. Overall, disease-free and recurrence-free survival were compared between the gastrectomy group of 6641 patients and the endoscopic dissection group of 999 patients to show the efficacy of the nomogram.
Results Multivariate analyses revealed that age, tumor size, lymphatic invasion, depth of invasion, and histologic differentiation were all significant prognostic factors for lymph node metastasis. The nomogram had good discriminatory performance, with a concordance index of 0.846. This was supported by the external validation point of 0.813. For patients with low risk of lymph node metastasis on the nomogram (≤ 3 % of the provisional value in this study), the endoscopic dissection and gastrectomy groups had comparable rates of overall (P = 0.32), disease-free (P = 0.47), and recurrence-free (P = 0.09) survival.
Conclusions We developed and validated a nomogram that predicts the risk of lymph node metastasis in EGC based on a large database. This precision nomogram is useful to avoid unnecessary gastrectomy after endoscopic dissection, which may ultimately improve the quality of life of patients with EGC.
The Use of Intraosseous Screw for Upper Molar Distalization: A Case Report
Authors: Polat-Özsoy Ömür 
Published: March 2020

ABSTRACTThe use of implants has made a major change in orthodontic treatment mechanics. They have replaced conventional unaesthetic and compliance dependent extraoral appliances with well accepted intraoral mechanics. Implants can be used in molar and canine distalization, intrusion and in extraoral force applications. In the present case report, treatment of a case using an intermaxillary fixation screw (IMF) will be presented. The treatment results will be evaluated using pretreatment, post distalization and post treatment cephalometric radiographs and dental casts. (Eur J Dent 2008;2:115-121)
Temporal Changes in Fibrinolysis following Injury
Authors: Moore Hunter B. , Moore Ernest E. 
Published: March 2020

AbstractTrauma patients present to the emergency department with a spectrum of fibrinolytic activity. This wide variance in fibrinolysis activity is a complex multifactorial process impacted by the degree of hemorrhagic shock and the amount of tissue injury the individual sustains. The fibrinolytic activity of the trauma patient at presentation to the hospital has prognostic and therapeutic implications. Those patients with high fibrinolytic activity (hyperfibrinolysis) are at risk of mortality from hemorrhage, whereas those patients with low fibrinolytic activity (shutdown or hypofibrinolysis) are at an increased risk of delayed mortality from traumatic brain injury or organ failure. These phenotypes of fibrinolysis acutely following injury change with resuscitation, and the majority of trauma patients will transition to a fibrinolytic resistant state several hours after injury. The mechanism for this near-global transition to this acquired fibrinolysis appears to be related to the generation of plasminogen activator inhibitor-1 in the liver. Those patients who do not recover from this fibrinolytic state 24 hours after injury have a poor prognosis. The purpose of this article is to review the different states of fibrinolytic activity following injury and how they change over time following resuscitation and in the intensive care unit.
Changes in Coagulation following Brain Injury
Authors: Maegele Marc , Aversa John , Marsee Mathew K. , McCauley Ross , Chitta Swetha Hanuma , Vyakaranam Sudhir , Walsh Mark 
Published: March 2020

AbstractTraumatic brain injury (TBI) is a worldwide public health concern due to increasing mortality, affecting around 10 million patients per year. A wide variety of clinical presentations are a function of the magnitude of injury and the anatomical perturbation of the brain parenchyma, supporting structures, and cerebral vasculature, with subsequent alteration of the blood–brain barrier. These disturbances correspond with the evolution of intracerebral hemorrhage and clinical outcomes. The associated hemostatic alterations associated with TBI are caused by the disruption of the delicate balance between bleeding and thrombosis formation, which can exacerbate initial injury. TBI-associated coagulopathy is a function of a cross-talk between coagulation and inflammation, with varying influences on the immunomodulation and regulation of coagulation that occur on platelets and the endothelium of injured TBI patients. In addition to the severity of initial injury, the following factors modulate the hemocoagulative response to TBI: time from the onset of injury to treatment, age, gender, catecholamine secretion, platelet dysfunction, endotheliopathy, premorbid anticoagulation, fibrinolysis, tissue factor, and activated protein C contribution. All these entities are intertwined and influence the pathologic evolution of TBI. These factors have implications for therapeutic options such as the choice of blood components for transfusion and hemostatic agents such as tranexamic acid. Monitoring hemostatic changes of TBI patients requires an understanding of these interactions between immunology and coagulation, which can be discerned by point-of-care viscoelastic testing with specific limitations. This review considers the implications of these interrelated influences on the evaluation of coagulopathy in TBI.
Trauma-Induced Coagulopathy in Children
Authors: Lucisano Amelia C. , Leeper Christine M. , Gaines Barbara A. 
Published: March 2020

AbstractTrauma-induced coagulopathy (TIC) is well documented in injured children. However, many important features of pediatric hemostasis are still in development in early childhood and may impact TIC. Certain pediatric subgroups are at a higher risk. Traumatic brain injury, which occurs with a higher rate in children, and physical child abuse are known risk factors for TIC that deserve special consideration. Resuscitation of a pediatric trauma patient follows many of the same goals as in the injured adult trauma, although some key aspects of pediatric resuscitation require ongoing investigation. Venous thromboembolism occurs with higher rates in certain high-risk groups of pediatric trauma patients, although overall it is considerably less frequent in children as compared with adults.
The effects of telicity, dynamicity and punctuality in L2 acquisition of Spanish Preterit and Imperfect
Authors: Quintana Hernández Lucía 
Published: March 2020

Abstract
The aim of this work is to investigate the use of Spanish Preterit and Imperfect by English speaking learners of L2 Spanish following the Lexical Aspect Hypothesis (Andersen & Shirai, 1996; Díaz, Bel, & Bekiou, 2008; Domínguez, Tracy-Ventura, Arche, Mitchell, & Miles, 2013; González, 2003, 2013; Montrul & Slabakova, 2002). The article studies how aspectual features bias Preterit and Imperfect in initial, intermediate and advanced learners. The results, based on an approximate binomial distribution analysis, confirm that Preterit is the preferred past, which supports L1 transfer (Salaberry & Shirai, 2002). The results also verify that Preterit is biased by dynamicity and punctuality at all levels. Telicity effects come into play in intermediate levels, while punctuality effects are reinforced in advanced levels. Stativity influences the use of Imperfect in intermediate level, which reveals that there are differences in the bias effect regarding proficiency level.
Speaker’s stance and subjectivity in the epistemic modal and evidential use of the Spanishimperfectoin journalistic texts
Authors: Böhm Verónica 
Published: March 2020

AbstractThis study contributes to the analysis of the epistemic modal and evidential use of the Spanishimperfectowith regard to the speaker’s stance and subjectively (rather than grammatically) motivated decision to use the Spanishimperfectoas an evidential strategy in journalistic texts: The speaker uses the Spanishimperfectoto express or tell a state of affairs from his perspective as a ‘narrator’, implying that he is not the author of such information and referring to third sources without mentioning it. The corpus data were obtained from theCorpus de la Real Academia Española(CREA) from the section ‘written journalistic texts’ of the standard Iberian Spanish to guarantee the authenticity of examples and avoid any case of misunderstanding it as a variety of Spanish.
Task and L1 effects
Authors: González Paz , Diaubalick Tim 
Published: March 2020

Abstract
Research on tense-aspect phenomena has shown that the type of experimental task can affect the performance of L2 learners. This pilot study on the understudied language combination Dutch-Spanish investigates this issue by focusing on the interaction between known affecting variables (inherent aspect; L1 effects) and different tasks (multiple-choice, fill-in-the-blanks, free production). First findings show that, indeed, both task type and L1 have an influence on the outcome. Generally, Dutch learners seem to prefer the Imperfect over the Preterit. This stands in contrast to previous research but can be explained by the imperfective features of the Dutch Simple Past with which the learners associate the L2 forms. Whereas this L1 effect is not visible in the multiple-choice task where the choice is forced, it manifests itself in tasks where students can choose freely between forms they know. Especially in the free production task, the L1 effect interacts with a high individual variability.