bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vivo anti‐hypertensive effect of peptides from egg white and its molecular mechanism with ACE
Authors: Yu Zhipeng , Wang Li , Wu Sijia , Zhao Wenzhu , Ding Long , Liu Jingbo 
Published: August 2020

SummaryPrevious work has demonstrated that peptides QIGLF and RVPSL exhibited in vitro ACE inhibitory activity. This study was aimed to evaluate the in vivo anti‐hypertensive effects of peptides RVPSL and QIGLF using animal experiments, and clarify the molecular mechanisms of interaction between ACE and peptides by molecular docking. In this work, the systolic blood pressure (SBP) of SHRs treated with QIGLF and RVPSL decreased by 48 ± 6 and 46 ± 6 mmHg, respectively. Docking results revealed that QIGLF and RVPSL established interactions with three main actives that of ACE, that is, S1 (Ala 354), S2 (Gln 281, His 513, Tyr 520 and Lys 511) and S1’ (Glu 162). These interactions can prevent ACE from binding to substrate and competitive inhibition. The in vivo anti‐hypertensive effect of QIGLF and RVPSL was consistent with their in vitro ACE inhibitory activity. QIGLF and RVPSL have potential to be a healthy functional food with anti‐hypertensive effects.
Danshen (Salvia miltiorrhiza) restricts MD2/TLR4‐MyD88 complex formation and signalling in acute myocardial infarction‐induced heart failure
Authors: Wang Xiaoping , Guo Dongqing , Li Weili , Zhang Qian , Jiang Yanyan , Wang Qiyan , Li Chun , Qiu Qi , Wang Yong 
Published: August 2020

AbstractHeart failure (HF) represents a major public health burden. Inflammation has been shown to be a critical factor in the progression of HF, regardless of the aetiology. Disappointingly, the majority of clinical trials targeting aspects of inflammation in patients with HF have been largely negative. Many clinical researches demonstrate that danshen has a good efficacy on HF, and however, whether danshen exerts anti‐inflammatory effects against HF remains unclear. In our study, the employment of a water extracted and alcohol precipitated of danshen extract attenuated cardiac dysfunction and inflammation response in acute myocardial infarction‐induced HF rats. Transcriptome technique and validation results revealed that TLR4 signalling pathway was involved in the anti‐inflammation effects of danshen. In vitro, danshen reduced the release of inflammatory mediators in LPS‐stimulated RAW264.7 macrophage cells. Besides, the LPS‐stimulated macrophage conditioned media was applied to induce cardiac H9C2 cells injury, which could be attenuated by danshen. Furtherly, knock‐down and overexpression of TLR4 were utilized to confirm that danshen ameliorated inflammatory injury via MyD88‐dependent TLR4‐TRAF6‐NF‐κB signalling pathway in cardiomyocytes. Furthermore, by utilizing co‐immunoprecipitation, danshen was proved to suppress MD2/TLR4 complex formation and MyD88 recruitment. In conclusion, our results demonstrated that danshen ameliorates inflammatory injury by controlling MD2/TLR4‐MyD88 complex formation and TLR4‐TRAF6‐NF‐κB signalling pathway in acute myocardial infarction‐induced HF.
Why did the invasive walking catfish cross the road? Terrestrial chemoreception described for the first time in a fish
Authors: Bressman Noah R. , Hill Jeffrey E. , Ashley‐Ross Miriam A. 
Published: August 2020

AbstractClarias batrachus (walking catfish) is an invasive species in Florida, renowned for its air‐breathing and terrestrial locomotor capabilities. However, it is unknown how this species orients in terrestrial environments. Furthermore, while anecdotal life history information is widespread for this species in its nonnative range, little of this information exists in the literature. The goals of this study were to identify sensory modalities that C. batrachus use to orient on land, and to describe the natural history of this species in its nonnative range. Fish (n = 150) were collected from around Ruskin, FL, and housed in a greenhouse, where experiments took place. Individual catfish were placed in the center of a terrestrial arena and were exposed to nine treatments: two controls, L‐alanine, quinine, allyl isothiocynate, sucrose, volatile hydrogen sulphide, pond water and aluminium foil. These fish exhibited significantly positive chemotaxis toward alanine and pond water, and negative chemotaxis away from volatile hydrogen sulphide, suggesting chemoreception – both through direct contact and through the air – is important to their terrestrial orientation. Additionally, 88 people from Florida wildlife‐related Facebook groups who have personal observations of C. batrachus on land were interviewed for information regarding their terrestrial natural history. These data were combined with observations from 38 YouTube videos. C. batrachus appear to emerge most frequently during or just after heavy summer rains, particularly from stormwater drains in urban areas, where they may feed on terrestrial invertebrates. By better understanding the full life history of C. batrachus, we can improve management of this species.
Mobility Action Group: Using Quality Improvement Methods to Create a Culture of Hospital Mobility
Authors: Lorgunpai Songprod Jonathan , Finke Bruce , Burrows Isaac , Brown Cynthia J. , Rubin Fred H. , Wierman Heidi R. , Heisey Susan J. , Gartaganis Sarah , Ling Shari M. , Press Matthew , Inouye Sharon K. 
Published: August 2020

Background/ObjectivesTo describe the Mobility Action Group (MACT), an innovative process to enhance implementation of hospital mobility programs and create a culture of mobility in acute care.DesignContinuous quality improvement intervention with episodic data review.SettingInpatient units including medical, surgical, and intensive care settings.ParticipantsA total of 42 hospitals of varying sizes across the United States.InterventionsThe MACT and Change Package were developed to provide a conceptual framework, road map, and step‐by‐step guide to enable mobility teams to implement mobility programs successfully and meet their mobilization goals. Participants were encouraged to select two to three change tactics to pursue during the first action cycle and select and implement additional tactics in subsequent cycles. Nine learning sessions were held via webinar from April 27, 2017, to October 5, 2017, during which faculty provided brief presentations, facilitation, and group discussion.MeasurementsImplementation of programs, walks per day, use of bed and chair alarms, and participant satisfaction.ResultsSuccessful implementation of mobility programs was achieved at most (76%) sites. The proportion of patients who received at least three walks per day increased from 9% to 19%. The proportion of patients who were placed on a bed or chair alarm decreased from 36% to 20%. On average, 69% of participants reported they were “strongly satisfied” with the learning sessions. Most participants found the Change Package (58%) and Toolkit (63%) “very helpful.” Since the conclusion of the active initiative, the Change Package has been downloaded 1,200 times. Of those who downloaded it, 48% utilized it to establish a mobility program, and 58% used it at their organization at least once a month.ConclusionThe MACT and Change Package provides an innovative approach emphasizing systemwide change that can help catalyze a culture of mobility in hospitals across the nation, improving the quality of care for hospitalized older adults. J Am Geriatr Soc 68:2373–2381, 2020.
Isobutylamido thiazolyl resorcinol for prevention of UVB‐induced hyperpigmentation
Authors: Vachiramon Vasanop , Kositkuljorn Chaninan , Leerunyakul Kanchana , Chanprapaph Kumutnart 
Published: August 2020

AbstractBackgroundIsobutylamido thiazolyl resorcinol (ITR, Thiamidol®) has been proposed as a potent tyrosinase inhibitor. A formulation containing ITR has recently shown promising efficacy for the treatment of some hyperpigmentary conditions.ObjectivesThis study aimed to evaluate the efficacy and safety of ITR in the prevention of ultraviolet (UV)‐induced hyperpigmentation in human skin.Materials and MethodsWe performed a randomized, single‐blinded, pilot study in 30 healthy participants. One arm was randomly assigned to receive an ITR‐containing product for three weeks. Three hyperpigmented spots were induced by UVB irradiation on both arms after 3 weeks of ITR application. Outcome evaluations included measuring mean lightness index (*L) obtained by colorimeter, hyperpigmentation scores by visual analog scale (VAS), and adverse effects.ResultsBoth experimental sides showed no significant difference in terms of skin lightening after ITR application. However, the ITR‐treated sides showed a statistically significant lower mean lightness index compared to control after an induction with UVB. In addition, the ITR‐treated sides had an earlier improvement and resumed the normal skin color after 3 weeks post‐UVB induction. A clinical evaluation by a blinded nontreating physician and subjects was more favorable on the ITR‐treated side than the control side (P < .05). No significant side effect was noted.ConclusionsITR is an effective agent in the prevention of pigmentary change from UVB irradiation and may serve as a promising agent for preventing other hyperpigmentary conditions.
Biophysical characteristics of dandruff‐affected scalp categorized on the basis of sebum levels
Authors: Yoon Ji‐Seon , Shim Jiyong , Lim Jun‐Man , Park Sun Gyoo 
Published: August 2020

AbstractBackgroundVarious sebum levels can be detected in dandruff‐affected scalps. However, few studies have compared the biophysical characteristics of dandruff scalps categorized based on sebum levels.AimsTo investigate and compare the biophysical characteristics of dandruff‐affected scalps categorized based on sebum levels.MethodsFifty‐four Korean women with dandruff and 30 healthy Korean women underwent physiological measurements, including evaluation of sebum and hydration levels, pH, and transepidermal water loss (TEWL) in the scalp. The levels of the biomarkers of interleukin‐8 (IL‐8) and kallikrein 5 (KLK5) and corneodesmosomes were investigated in the stratum corneum (SC) of the scalp.ResultsDandruff was categorized as dry (low‐sebum, n = 25) or oily (high‐sebum, n = 29) based on a sebum cutoff level of 97.82 μg/cm2. Both dry and oily dandruff‐affected scalps showed significantly decreased hydration levels and increased pH and TEWL compared with healthy subjects, with hydration levels being lower in dry dandruff‐affected scalps. IL‐8 expression was significantly increased in the oily dandruff‐affected scalp. In addition, both dry and oily dandruff‐affected scalps showed significantly increased KLK5 levels in the SC, with the levels being higher in oily dandruff‐affected scalps. Altered distribution of corneodesmosomes, present on the entire surface area of the corneocytes, was notable in oily dandruff‐affected scalps.ConclusionThe biophysical characteristics of the two types of dandruff represent the influence of different characteristics, including hydration levels, expression of IL‐8 and KLK5, and corneodesmosome distribution. Thus, strategies to reduce dandruff levels should differ according to sebum levels.
Ultrasound assessment of tissue integration of the crosslinked hyaluronic acid filler VYC‐25L in facial lower‐third aesthetic treatment: A prospective multicenter study
Authors: Urdiales‐Gálvez Fernando , Barres‐Caballer Jordán , Carrasco‐Sánchez Sara 
Published: August 2020

AbstractBackgroundDermal fillers have become an integral part of any aesthetic physician's intervention.AimsTo assess, by means of ultrasounds, the tissue integration of the hyaluronic acid (HA) dermal filler VYC‐25L in chin and jaw.MethodsProspective, noncomparative, open‐label, and multicenter study conducted on healthy subjects, with age comprised between 30 and 60 years old, who attended to the clinic to perform a facial rejuvenation treatment of the lower third of the face. VYC‐25L was injected using a 27G needle (supraperiosteal bolus, from 0.2 to 0.3 mL per bolus) in the chin and with canula (retrograde threads, from 0.4 to 0.6 mL) in the jaw. Ultrasound examinations (UE) were performed at each study center by the same experienced observer at baseline, immediately after injection, 48 hours, and 30 days after treatment.ResultsThirty patients (10 per center) were included in the study. At baseline, UE found a characteristic heterogeneous pattern of subcutaneous cellular tissue, with alternation of soft anechoic and hyperechoic images. The UE, performed immediately after treatment, showed a poorly defined globular ultrasound pattern, with anechoic images indicative of liquid content. Forty‐eight hours after treatment, UE are still showing a globular pattern, with well‐defined anechoic areas. Thirty days after treatment, a thickening of the subcutaneous cellular tissue was observed in all the evaluated zones, with a total integration of the HA into the tissue.ConclusionVYC‐25L might represent a significant advance in volumization/restoration of the lower face. Its biointegration was total at day 30 and practically complete at 48 hours of treatment.
Nurses’ role in health promotion and prevention: A critical interpretive synthesis
Authors: Iriarte‐Roteta Andrea , Lopez‐Dicastillo Olga , Mujika Agurtzane , Ruiz‐Zaldibar Cayetana , Hernantes Naia , Bermejo‐Martins Elena , Pumar‐Méndez María J. 
Published: August 2020

AbstractBackgroundRole confusion is hampering the development of nurses' capacity for health promotion and prevention. Addressing this requires discussion to reach agreement among nurses, managers, co‐workers, professional associations, academics and organisations about the nursing activities in this field. Forming a sound basis for this discussion is essential.Aims and objectivesTo provide a description of the state of nursing health promotion and prevention practice expressed in terms of activities classifiable under the Ottawa Charter and to reveal the misalignments between this portrayal and the ideal one proposed by the Ottawa Charter.MethodsA critical interpretive synthesis was conducted between December 2018 and May 2019. The PubMed, CINAHL, Scopus, PsychINFO, Web of Science and Dialnet databases were searched. Sixty‐two papers were identified. The relevant data were extracted using a pro‐forma, and the reviewers performed an integrative synthesis. The ENTREQ reporting guidelines were used for this review.ResultsThirty synthetic constructs were developed into the following synthesising arguments: (a) addressing individuals' lifestyles versus developing their personal skills; (b) focusing on environmental hazards versus creating supportive environments; (c) action on families versus strengthening communities; (d) promoting community partnerships versus strengthening community action; and (e) influencing policies versus building healthy public policy.ConclusionsThere are notable misalignments between nurses' current practice in health promotion and prevention and the Ottawa Charter's actions and strategies. This may be explained by the nurses' lack of understanding of health promotion and prevention and political will, research methodological flaws, the predominance of a biomedical perspective within organisations and the lack of organisational prioritisation for health promotion and prevention.
A cross‐sectional study of mental health status and self‐psychological adjustment in nurses who supported Wuhan for fighting against the COVID‐19
Authors: Chen Huijuan , Sun Libing , Du Zhe , Zhao Liting , Wang Ling 
Published: August 2020

AbstractAims and objectivesTo evaluate the mental health status, stressors and self‐adjustment of nurses in isolation wards at different periods in Wuhan, China.BackgroundMental health issues easily occurred among the frontline medical workers of a major epidemic. However, the stressors and psychological adjustments experienced by nurses have not been well described. This is crucial to improving clinical quality and nursing safety and ensuring nurses’ physical and psychological health.MethodsWe performed a cross‐sectional prospective study using the Self Reporting Questionnaire‐20, stressor and self‐adjustment questionnaire administered to frontline nurses in Wuhan at two time points: after they had worked in isolation wards for 7–10 days (T1) and 2 months (T2). This paper complies with the STROBE reporting guideline for cross‐sectional studies.ResultsT1 has 92 respondents, and T2 has 86. The positive rates of mental health problems were 26.09% and 9.30%, respectively, showing significantly different in the two periods. The main factors influenced mental health were self‐perceived stress and only child status. The most common stressors were as follows: a large infected population, high infectivity; concerned about family's health status; high mortality if not treated in time (T1); and long duration of the epidemic, separate from family for a long time (T2). In terms of self‐adjustment, 97.83%(T1)/88.04%(T2) of nurses thought it was necessary, but 9(T1) /5(T2) chose to avoid addressing it, and 8(T1) /5(T2) utilised a professional psychological counselling hotline.ConclusionsMental health problems among frontline nurses fighting COVID‐19 need special attention, so administrators should offer timely counselling and strengthen effective psychosocial support to improve their mental resilience.Relevance to clinical practiceThis study surveyed the mental problems and self‐adjustment status among nurses working Wuhan during the outbreak of COVID‐19, to provide administrators with a scientific basis to effectively intervene.
Community Eligibility Provision and School Meal Participation among Student Subgroups
Authors: Tan May Lynn , Laraia Barbara , Madsen Kristine A. , Johnson Rucker C. , Ritchie Lorrene 
Published: August 2020

ABSTRACTBACKGROUNDThe National School Lunch and Breakfast Programs help to reduce food insecurity and improve nutrition. The Community Eligibility Provision (CEP) enables high‐poverty schools to offer breakfast and lunch at no cost to all students. This study examines associations between CEP and participation among students eligible for free or reduced‐price meals (“FRPM”), possibly eligible (“near‐cutoff”), or ineligible (“full‐price”).METHODSUsing data from the 2013‐2015 Healthy Communities Study, we compared school breakfast and lunch participation between 842 students in K‐8 at 80 CEP schools and 1463 students at 118 schools without CEP. Cross‐sectional difference‐in‐difference (DID) models compared meal participation among near‐cutoff and full‐price groups to that in the FRPM group.RESULTSOverall, FRPM students had high participation in school lunch and breakfast at both types of schools. In adjusted DID models, lunch participation among near‐cutoff students was 12 points higher in CEP versus comparison schools (p < .05). Among full‐price students, breakfast participation was 20 points higher and lunch participation 19 points higher in CEP than comparison schools (p < .001).CONCLUSIONSCommunity Eligibility Provision improves access to school breakfast and lunch in high‐poverty schools, particularly for students who are near or above the cutoff for FRPM eligibility.
Defining just‐about‐right concentration for doenjang soup appealing to Korean consumers
Authors: Chon Seo‐yeong , Kim Mina K. 
Published: August 2020

AbstractDoenjang refers to a traditional food ingredient in Korea, commonly consumed as a soup (jjigae). The objective of this study was to define the just‐about‐right (JAR) concentration of doenjang soup that appealed to Korean consumers. Doenjang soup recipes were standardized, and the various concentrations of doenjang paste in soup were selected as 5, 7.5, 10, and 12.5%. Physiochemical analysis of doenjang soups with different concentrations was conducted, which was followed by a consumer acceptance test using students at Jeonbuk National University (N = 91). Increased salinity and °Brix were observed as the doenjang paste concentration increased (p < .05). Overall liking score also increased with increasing concentrations of doenjang paste in the soup (p < .05), whereas 5% doenjang paste concentration received the lowest overall liking scores (4.07 on a 9‐point hedonic scale), which corresponded to 0.93% salinity. When 5% doenjang paste was applied to the soup, consumers perceived that it contained fewer ingredients (p < .05). A JAR saltiness score revealed that 7.5% concentration of doenjang paste in soup was perceived to have JAR saltiness by consumers.Practical applicationsDoenjang is a widely accepted fermented food ingredient in Korea. However, cooking methods using doenjang have not yet been standardized. This study reports the just‐about‐right (JAR) concentration of doenjang paste in a soup (jjigae‐type). Findings from this study can aid sensory and food scientists in the field to design proper sample serving protocols of doenjang jjigae and specialists in culinary arts to develop and optimize recipes using doenjang in a manner that appeals to consumers.
Stigma Toward Persons with Intellectual Disability in South America: A Narrative Review
Authors: Tenorio Marcela , Donoso Javiera , Ali Afia , Hassiotis Angela 
Published: August 2020

AbstractPeople with intellectual disability (ID) form one of the most underserved/stigmatized groups in society. Published data have documented stigma toward this population group in different countries. However, this phenomenon has received scant attention in South American countries. The aim of this work is to conduct a systematic search of published and gray literature in the area of stigma toward persons with ID within the 12 countries of the region to explore expression of stigma toward people with ID in the region. Systematic research of published data and gray literature, based on a previous published protocol, was run in this work. The search strategy included terms related to IDs being combined with stigma, prejudice, attitudes and stereotypes, and with the names of all the South American countries. Due to the known relationship between ID and Autism Spectrum Disorder, this term was included in the search. The search was conducted in English, Spanish, and Portuguese. A narrative approach to results is presented. Available information is organized by stakeholder groups, including persons with ID, families, caregivers, and mental health workers. The quality of the studies was analyzed based on the Mixed Method Appraisal Tool Version 2018, and results are variable. The results of the narrative review are indicative of the limited scientific study of stigma toward people with ID in South American countries and the clear sense that people with ID living in those countries report experience of stigmatizing attitudes. Future research, at population level, is needed in the region to ensure improvements in the quality of life and in the civil participation of people with ID.