bluuebunny/crossref_metadata_2025_split huggingface dataset:
Craniosacral therapy for chronic pain: a systematic review and meta-analysis of randomized controlled trials
Authors: Haller Heidemarie , Lauche Romy , Sundberg Tobias , Dobos Gustav , Cramer Holger 
Published: December 2019

Abstract
Objectives
To systematically assess the evidence of Craniosacral Therapy (CST) for the treatment of chronic pain.

Methods
PubMed, Central, Scopus, PsycInfo and Cinahl were searched up to August 2018. Randomized controlled trials (RCTs) assessing the effects of CST in chronic pain patients were eligible. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated for pain intensity and functional disability (primary outcomes) using Hedges’ correction for small samples. Secondary outcomes included physical/mental quality of life, global improvement, and safety. Risk of bias was assessed using the Cochrane tool.

Results
Ten RCTs of 681 patients with neck and back pain, migraine, headache, fibromyalgia, epicondylitis, and pelvic girdle pain were included. CST showed greater post intervention effects on: pain intensity (SMD = -0.32, 95%CI = [− 0.61,-0.02]) and disability (SMD = -0.58, 95%CI = [− 0.92,-0.24]) compared to treatment as usual; on pain intensity (SMD = -0.63, 95%CI = [− 0.90,-0.37]) and disability (SMD = -0.54, 95%CI = [− 0.81,-0.28]) compared to manual/non-manual sham; and on pain intensity (SMD = -0.53, 95%CI = [− 0.89,-0.16]) and disability (SMD = -0.58, 95%CI = [− 0.95,-0.21]) compared to active manual treatments. At six months, CST showed greater effects on pain intensity (SMD = -0.59, 95%CI = [− 0.99,-0.19]) and disability (SMD = -0.53, 95%CI = [− 0.87,-0.19]) versus sham. Secondary outcomes were all significantly more improved in CST patients than in other groups, except for six-month mental quality of life versus sham. Sensitivity analyses revealed robust effects of CST against most risk of bias domains. Five of the 10 RCTs reported safety data. No serious adverse events occurred. Minor adverse events were equally distributed between the groups.

Discussion
In patients with chronic pain, this meta-analysis suggests significant and robust effects of CST on pain and function lasting up to six months. More RCTs strictly following CONSORT are needed to further corroborate the effects and safety of CST on chronic pain.

Protocol registration at Prospero
CRD42018111975.
Medical graduate views on statistical learning needs for clinical practice: a comprehensive survey
Authors: MacDougall Margaret , Cameron Helen S. , Maxwell Simon R. J. 
Published: December 2019

AbstractBackgroundThis paper seeks to contribute to a reputable evidence base for required competencies across different topics in statistics and probability (statistical topics) in preparing medical graduates for clinical practice. This is in order to inform the prioritization of statistical topics within future undergraduate medical curricula, while exploring the need for preparing tomorrow’s doctors to be producers, and not merely consumers, of statistics.MethodsWe conducted a comprehensive online survey from July 2013 to August 2014 for a target group of 462 medical graduates with current or prior experience of teaching undergraduate medical students of the University of Edinburgh of whom 278 (60.2%) responded. Statistical topics were ranked by proportion of respondents who identified the practice of statistics,performing statistical procedures or calculations using appropriate data, as a required competency for medical schools to provide in preparing undergraduate medical students for clinical practice. Mixed effects analyses were used to identify potential predictors for selection of the above competency and to compare the likelihood of this selection for a range of statistical topics versus critical appraisal.ResultsEvidence was gleaned from medical graduates’ experiences of clinical practice for the need for, not only a theoretical understanding of statistics and probability but also, the ability to practice statistics. Nature of employment and statistical topic were highly significant predictors of choice of the practice of statistics as a required competency ((F = 3.777, p < 0.0005) and (F = 45.834, p < 0.0005), respectively). The most popular topic for this competency was graphical presentation of data (84.3% of respondents) in contrast to cross-over trials for the competency understanding the theory only (70.5% of respondents). Several topics were found to be more popular than critical appraisal for competency in the practice of statistics.ConclusionsThe model of medical graduates as mere consumers of statistics is oversimplified. Contrary to what has been suggested elsewhere, statistical learning opportunities in undergraduate medicine should not be restricted to development of critical appraisal skills. Indeed, our findings support development of learning opportunities for undergraduate medical students as producers of statistics across a wide range of statistical topics.
The impact of the presence of fibromyalgia on fatigue in patients with psoriatic arthritis: comparison with controls
Authors: Ulus Yasemin , Akyol Yesim , Bilgici Ayhan , Kuru Omer 
Published: December 2019

AbstractBackgroundCoexisting fibromyalgia (FM) to psoriatic arthritis (PsA) has been identified and it has been associated with more severe symptoms, impaired function, and greater disability. It was aimed to explore the effect of the presence of FM on fatigue in patients with PsA comparing with controls.MethodsFifty patients with PsA and 34 sex-age matched controls were enrolled. In patients; pain was assessed by Visual Analogue Scale, disease activity by DAS-28, enthesitis by The Leeds Enthesitis Index. Fatigue level of all participants was evaluated by Multidimensional Assessment of Fatigue. In all participants, FM was determined according to 2010 American College of Rheumatology criteria.ResultsSeventeen patients with PsA (34%) and 4 controls (11.8%) were diagnosed with FM and all of them were women. There was significant difference between the patients and controls in terms of presence of FM (p < 0.05). Patients’ fatigue scores were significantly higher than controls’ (p = 0.001). There were significant differences between the PsA patients with and without FM with regard to gender, enthesitis, DAS-28 and pain scores (p < 0.05); fatigue scores (p < 0.001). The significant effect of the presence of FM on fatigue was found by univariate analysis of variance in patients (p < 0.001).ConclusionIt was observed that FM presence and fatigue were more common in PsA patients than controls and comorbid FM had significant effect on fatigue in these patients. Physicians should be aware of the possibility of concomitant FM in patients with PsA.
Platelet/lymphocyte ratio and mean platelet volume in patients with granulomatosis with polyangiitis
Authors: Kucuk Hamit , Tecer Duygu , Goker Berna , Varan Ozkan , Babaoglu Hakan , Guven Serdar Can , Ozturk Mehmet Akif , Haznedaroglu Seminur , Tufan Abdurrahman 
Published: December 2019

AbstractBackgroundGranulomatosis with polyangiitis (GPA) is a granulomatous necrotizing vasculitis with high morbidity and mortality. Anti-neutrophil cytoplasmic antibody is a valuable diagnostic marker, however its titer lacks predictive value for the severity of organ involvement. Platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) has been regarded as a potential marker in assessing systemic inflammation. We aimed to explore the value of PLR and MPV in the assessment of disease activity and manifestations of disease in GPA.Methods56 newly diagnosed GPA patients and 53 age-sex matched healthy controls were included in this retrospective and cross-sectional study with comparative group. Complete blood count was performed with Backman Coulter automatic analyzer, erythrocyte sedimentation rate (ESR) with Westergen method and C-reactive protein (CRP) levels with nephelometry. The PLR was calculated as the ratio of platelet and lymphocyte counts.ResultCompared to control group, ESR, CRP and PLR were significantly higher and MPV significantly lower in GPA patients. In patients group, PLR was positively correlated with ESR and CRP (r = 0.39,p = 0.005 andr = 0.51,p < 0.001, respectively). MPV was negatively correlated with ESR and CRP (r = − 0.31,p = 0.028 andr = − 0.34p = 0.014, respectively). Patients with renal involvement had significantly higher PLR than patients without renal involvement (median:265.98, IQR:208.79 vs median:180.34 IQR:129.37,p = 0.02). PLR was negatively correlated with glomerular filtration rate (r = − 0.27,p = 0.009). A cut-off level of 204 for PLR had 65.6% sensitivity and 62.5 specificity to predict renal involvement.ConclusionPLR exhibit favorable diagnostic performance in predicting renal involvement in patients with GPA.
Microscopic study of zinc nanoparticles synthesised using thermosetting polymer
Authors: Tailor Giriraj , Chaudhay Jyoti , Verma Deepshikha , Kr. Sarma Bhupendra 
Published: December 2019

AbstractThe present study reports the novel synthesis of Zinc nanoparticles (Zn NPs) by thermal decomposition method and its characterisation by Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM), and X-ray Diffraction Measurements (XRD). Synthesis of Zn NPs was achieved by using thermosetting polymer and zinc salts as precursor. Zn NPs were obtained on calcination at 850 °C for 30 min. SEM study reveals that synthesized nanoparticles are spherical in shape. XRD analysis shows that the Zn NPs formed are low crystalline in nature.
Outcome Differences of Remnant- Preserving versus Non-Preserving Methods in Arthroscopic Anterior Cruciate Ligament Reconstruction: A Meta-analysis with Subgroup analysis
Authors: Won Sung Hun , Lee Byung-Il , Park Su Yeon , Min Kyung-Dae , Kim Jun-Bum , Kwon Sai-Won , Kim Yong-Beom , Seo Gi-Won , Kim Jae-Hyung , Choi Hyung-Suk 
Published: December 2019

Abstract
Purpose
To analyze differences in clinical outcomes of arthroscopic anterior cruciate ligament reconstruction between remnant-preserving and non-preserving methods.

Methods
International electronical databases PubMed, Embase, and the Cochrane central database from January 1966 to December 2017 were searched for randomized controlled trials (RCTs) and observational studies that compared differences of clinical outcomes of ACL reconstruction with and without remnant preservation. A meta-analysis of these studies was performed to compare clinical outcomes. Subgroup analyses were conducted to evaluate the role of methodological quality in primary meta-analysis estimates.

Results
Five RCTs and six observational studies were included in this meta-analysis and subgroup analysis. The remnant-preserving method in arthroscopic ACL reconstruction showed a statistically significant difference compared to the non-preserving method regarding arthrometric evaluation (side-to-side difference). Lachman test, Lysholm scores, and IKDC subjective scores showed statistically minor difference in meta-analysis, but showed no significant difference in subgroup analysis. Remained parameters including pivot shift test, IKDC grades, incidence of cyclops lesion showed no statistically differences in meta-analysis or subgroup analysis.

Conclusions
This meta-analysis with subgroup analysis showed that arthroscopic remnant-preserving ACL reconstruction provided statistically significant but limited clinical relevance in terms of arthrometric evaluation. Results of Lachman test, Lysholm scores, and IKDC subjective scores demonstrated statistically minor differences.
Longitudinal Changes in Children’s Accelerometer-derived Activity Pattern Metrics
Authors: DUNTON GENEVIEVE F. , YANG CHIH-HSIANG , ZINK JENNIFER , DZUBUR ELDIN , BELCHER BRITNI R. 
Published: December 2019

ABSTRACT

Purpose
The objective of this study was to quantify age-related changes in accelerometer-derived day-level physical activity and sedentary behavior pattern metrics (i.e., number, length, and temporal dispersion of bouts and breaks) across 3 yr of middle childhood. Differences by child sex and weekend versus weekday were examined.

Method
Children (N = 169, 54% female, 56% Hispanic; 8–12 yr old at enrollment) participated in a longitudinal study with six assessments across 3 yr. Day-level moderate-to-vigorous physical activity (MVPA; i.e., total minutes, number of short (<10 min) bouts, proportion of long (≥20 min) bouts, temporal dispersion) and sedentary behavior (i.e., total minutes, number of breaks, proportion of long (≥60 min) bouts, temporal dispersion) pattern metrics were measured using a waist-worn accelerometer (Actigraph GT3X).

Results
Random intercept multilevel linear regression models showed that age-related decreases in the number of short MVPA bouts per were steeper for girls than for boys (b = −1.28; 95% confidence interval (CI), −1.93 to −0.64; P < 0.01) and on weekend days than on weekdays (b = −1.82; 95% CI, −2.36 to −1.29; P < 0.01). The evenness of the temporal dispersion of MVPA across the day increased more on weekend days than on weekdays as children got older (b = −0.02; 95% CI, −0.02 to −0.01; P < 0.01). Girls had steeper age-related decreases in the number of sedentary breaks per day (b = −2.89; 95% CI, −3.97 to −1.73; P < 0.01) and the evenness of the temporal dispersion of sedentary behavior across the day (b ≤ 0.01; 95% CI, <0.01 to 0.01; P < 0.01) than did boys. Changes in sedentary behavior metrics did not differ between weekend days and weekdays.

Conclusion
Strategies to protect against declines in short physical activity bouts and promote sedentary breaks, especially among girls and on weekend days, could reduce cardiometabolic risks.
Three and a half years’ experience with outpatient total hip arthroplasty
Authors: Coenders Michel J. , Mathijssen Nina M. C. , Vehmeijer Stephan B. W. 
Published: December 2019

Aims The aim of this study was to report our experience at 3.5 years with outpatient total hip arthroplasty (THA). Methods In this prospective cohort study, we included all patients who were planned to receive primary THA through the anterior approach between 1 April 2014 and 1 October 2017. Patient-related data and surgical information were recorded. Patient reported outcome measures (PROMs) related to the hip and an anchor question were taken preoperatively, at six weeks, three months, and one year after surgery. All complications, readmissions, and reoperations were registered. Results Of the 647 THA patients who had surgery in this period through the anterior approach, 257 patients (39.7%) met the inclusion criteria and were scheduled for THA in an outpatient setting. Of these, 40 patients (15.6%) were admitted to the hospital, mainly because of postoperative nausea and/or dizziness. All other 217 patients were able to go home on the day of surgery. All hip-related PROMs improved significantly up to 12 months after surgery, compared with the scores before surgery. There were three readmissions and two reoperations in the outpatient cohort. There were no complications related to the outpatient THA protocol. Conclusion These study results confirm that outpatient THA can be performed safe and successfully in a selected group of patients, with satisfying results up to one year postoperatively, and without outpatient-related complications, readmissions, and reoperations. Cite this article: Bone Joint J 2020;102-B(1):82–89
Restoring the constitutional alignment with a restrictive kinematic protocol improves quantitative soft-tissue balance in total knee arthroplasty: a randomized controlled trial
Authors: MacDessi Samuel J. , Griffiths-Jones William , Chen Darren B. , Griffiths-Jones Sam , Wood Jil A. , Diwan Ashish D. , Harris Ian A. 
Published: December 2019

AimsIt is unknown whether kinematic alignment (KA) objectively improves knee balance in total knee arthroplasty (TKA), despite this being the biomechanical rationale for its use. This study aimed to determine whether restoring the constitutional alignment using a restrictive KA protocol resulted in better quantitative knee balance than mechanical alignment (MA).MethodsWe conducted a randomized superiority trial comparing patients undergoing TKA assigned to KA within a restrictive safe zone or MA. Optimal knee balance was defined as an intercompartmental pressure difference (ICPD) of 15 psi or less using a pressure sensor. The primary endpoint was the mean intraoperative ICPD at 10° of flexion prior to knee balancing. Secondary outcomes included balance at 45° and 90°, requirements for balancing procedures, and presence of tibiofemoral lift-off.ResultsA total of 63 patients (70 knees) were randomized to KA and 62 patients (68 knees) to MA. Mean ICPD at 10° flexion in the KA group was 11.7 psi (SD 13.1) compared with 32.0 psi in the MA group (SD 28.9), with a mean difference in ICPD between KA and MA of 20.3 psi (p < 0.001). Mean ICPD in the KA group was significantly lower than in the MA group at 45° and 90°, respectively (25.2 psi MA vs 14.8 psi KA, p = 0.004; 19.1 psi MA vs 11.7 psi KA, p < 0.002, respectively). Overall, participants in the KA group were more likely to achieve optimal knee balance (80% vs 35%; p < 0.001). Bone recuts to achieve knee balance were more likely to be required in the MA group (49% vs 9%; p < 0.001). More participants in the MA group had tibiofemoral lift-off (43% vs 13%; p < 0.001).ConclusionThis study provides persuasive evidence that restoring the constitutional alignment with KA in TKA results in a statistically significant improvement in quantitative knee balance, and further supports this technique as a viable alternative to MA. Cite this article: Bone Joint J. 2020;102-B(1):117–124
Prospective investigation of the relationship between dorsal tilt, carpal malalignment, and capitate shift in distal radial fractures
Authors: Dias Rachel , Johnson Nick A. , Dias Joseph J. 
Published: December 2019

Aims Carpal malalignment after a distal radial fracture occurs due to loss of volar tilt. Several studies have shown that this has an adverse influence on function. We aimed to investigate the magnitude of dorsal tilt that leads to carpal malalignment, whether reduction of dorsal tilt will correct carpal malalignment, and which measure of carpal malalignment is the most useful. Methods Radiographs of patients with a distal radial fracture were prospectively collected and reviewed. Measurements of carpal malalignment were recorded on the initial radiograph, the radiograph following reduction of the fracture, and after a further interval. Linear regression modelling was used to assess the relationship between dorsal tilt and carpal malalignment. Receiver operating characteristic (ROC) analysis was used to identify which values of dorsal tilt led to carpal malalignment. Results A total of 250 consecutive patients with 252 distal radial fractures were identified. All measures of carpal alignment were significantly associated with dorsal tilt at each timepoint. This relationship persisted after adjustment for age, sex, and the position of the wrist. Capitate shift consistently had the strongest relationship with dorsal tilt and was the only parameter that was not influenced by age or the position of the wrist. ROC curve analysis identified that abnormal capitate shift was seen with > 9° of dorsal tilt. Conclusion Carpal malalignment is related to dorsal tilt following a distal radial fracture. Reducing the fracture and improving dorsal tilt will reduce carpal malalignment. Capitate shift is easy to assess visually, unrelated to age and sex, and appears to be the most useful measure of carpal malalignment. The aim during reduction of a distal radial fracture should be to realign the capitate with the axis of the radius and prevent carpal malalignment. Cite this article: Bone Joint J 2020;102-B(1):137–143
The tragic Rasa in G. Sankara Pillai’s plays
Authors: Paniker Ayyappa 
Published: December 2019

Abstract
This article can be described as an attempt to examine whether tragedy (Duranta) can be a Rasa. The inquiry must start with the term itself: the Duranta Rasa. Such a Rasa has not so far been heard of or come across. Is there such a Rasa at all? It has not been named by anyone in the line of theorists beginning with Bharatha. These are questions that I have put myself, and the essay should not be thought to have been written after having found the answers. It is, in fact, a quest for the answers – its central object is to search rather than to reach conclusions. In fact, the whole of Sankara Pillai’s life itself was devoted to an exploration of the nature of drama – its form, its structure, its meaning, its relevance. Each play of his was a step, a stage in this inquiry. Sankara Pillai does not claim that his inquiry has borne full fruit. Nor do I for my effort.
Synthesis and Evaluation of Novel Fluorobenzimidazole Derivatives as Antibacterial and Antifungal Agents
Authors: Joshi D. , Narigara R. , Jani G. , Parikh K. 
Published: December 2019

A new class of fluorobenzimidazole derivatives (IIIa-j)was synthesized to investigate their antimicrobial potential. All the compounds were prepared by multiple step synthesis, initiating from the synthesis of 5-(difluoromethoxy)-1H-benzimidazole-2-thiol (I). The compound I was further reacted with different derivatives of 2-chloro-N-phenylacetamide (IIa-j) prepared by reacting differently substituted anilines with chloroacetylchloride and triethylamine in DMF (solvent); resulting in formation of fluorobenzimidazoles IIIa-j. The compounds IIIa-j were characterized by spectral analysis viz. 1H NMR, 13C NMR, mass spectra, elemental analysis and IR. All these compounds were screened in vitro for their antimicrobial activity against Gram-positive (S. aureus and E. faecalis) and Gram-negative bacterial (E. coli and P.aeruginosa) strains as well as fungi (A. niger and C. albicans). Some of the compounds exhibited promising results (in MIC) against Gram-negative bacterial strains.
ARMAZENAMENTO DE MEDICAMENTOS NA CENTRAL DE ABASTECIMENTO FARMACÊUTICO (CAF) DE UM MUNICÍPIO DO RIO GRANDE DO NORTE, BRASIL
Authors: Gomes George Sillas Silva , Mariz Batista Almária 
Published: December 2019

Medicamentos representam a perspectiva de resolutividade de grande parte agravos de saúde. A preservação da sua qualidade deve ser garantida desde a fabricação até a dispensação ao paciente. Nesse sentido, o presente estudo analisou o processo de armazenamento de medicamentos na Central de Abastecimento Farmacêutico do município de Currais Novos, RN, Brasil. Trata-se de um estudo transversal, de caráter descritivo-exploratório, desenvolvido no mês de maio de 2018. A coleta de dados se deu por meio da aplicação de roteiro de inspeção, elaborado com base nas Boas Práticas para Estocagem de Medicamentos e nos requisitos de armazenamento preconizados pela RDC nº 44/09, da Anvisa. Dos 16 itens avaliados, 44% apresentaram não conformidade. Itens como inexistência de procedimentos operacionais padrão, iluminação e instalações elétricas inadequadas e monitoramento de temperatura e umidade compuseram os itens em não conformidade. O sistema de armazenamento da Central de Abastecimento Farmacêutico do município de Currais Novos, RN, única responsável pelo armazenamento e pela dispensação de medicamentos do componente básico da Assistência Farmacêutica para a população de todos os bairros, necessita ser otimizado em diversos pontos, visando ao fortalecimento do ciclo da assistência farmacêutica. O farmacêutico se apresenta como profissional fundamental para liderar esse processo, para uma dispensação mais efetiva e segura para o paciente que necessita do acesso ao medicamento.
Crystal structure of bis(N′-((5-(ethoxycarbonyl)-1H-pyrrol-2-yl)methylene)-N-ethylcarbamohydrazonothioato-κ2N,O)nickel(II), C22H30N8O4S2Ni
Authors: Chen Kui-Kui , Huang Jing-Tao , Lin Long , Wu Wei-Na 
Published: December 2019

Abstract
C22H30N8O4S2Ni, monoclinic, P21/c (no. 14), a = 10.635(2) Å, b = 10.308(2) Å, c = 12.444(3) Å, β = 101.205(4)°, V = 1338.2(5) Å3, Z = 2, R
gt(F) = 0.0417, wR
ref(F
2) = 0.0937, T = 296(2) K.