bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bicycle Tourism as a Sustainable Tourism Alternative in Two Rural Areas of Santo Domingo in Ecuador
Authors: Patricio Galarza Pucha Jairo , Yoarnelys Vasallo-Villalonga 
Published: December 2024

Objective: This study aims to identify the profile of cycle tourists visiting the rural areas of San Gabriel de Baba and Julio Moreno, located in Santo Domingo de los Tsáchilas, Ecuador.

Theoretical Framework: Sustainable tourism is defined as an activity that considers economic, social, and environmental factors to ensure the satisfaction of both users and host communities.

Method: A descriptive method was employed, applying surveys to four study groups with differentiated questionnaires, revealing heterogeneous variability in the responses.

Results and Discussion: The results show that these rural areas significantly contribute to sustainable tourism through bicycle usage. However, respondents highlighted the need to improve road signage and safety for cyclists. This aligns with previous studies in Latin America that emphasize the lack of resources in rural areas for infrastructure and the promotion of sustainable tourism.

Research Implications: A lack of precise information is observed, which hinders the development of effective marketing strategies for cycle tourism ventures in these areas. The research is considered preliminary due to the limited information available on tourism in the areas studied and the absence of prior analyses characterizing cycle tourists.

Originality/Value: In this regard, the descriptive approach adopted allows for the proposal of tools to promote cycle tourism and improve conditions for local communities, thus enhancing the development of economically viable and environmentally responsible tourism.
Adoption of Circular Economy in Sustainable Agriculture Practices in Magelang District: Influence on Productivity and Farmer Welfare
Authors: Prasetyo Andreas Yogi , Yudhanto Wildan , Nurlina Nila , Rosyidah Hani , Indrayati Lyna Lestari 
Published: December 2024

Objective: The objective of this study is to investigate the adoption of circular economy principles in sustainable agriculture practices in Magelang district, focusing on their impact on agricultural productivity and farmer welfare, with the aim of assessing how circular economy practices contribute to sustainable agriculture by improving resource efficiency, enhancing productivity, and promoting farmer welfare in Magelang district.

Theoretical Framework: The theoretical framework of this study is grounded in the priciples of the circular economy, which emphasize maximizing resource efficiency, minimizing waste, and fostering environmental regeneration. In agriculture, these principles align with sustainable practices by promoting the reuse of organic materials, efficient resource management, and the reduction of chemical inputs to maintain soil fertility and ecosystem balance. By integrating circular economy principles with sustainable agricultural practices, this framework aims to enhance productivity, reduce costs, and improve farmers’ welfare while ensuring long-term environmental resilience.

Method: Using a quantitative approach that includes surveys of 100 farmers and in-depth interviews, this research evaluates the implementation of CE principles, such as composting organic waste, rainwater harvesting, and crop rotation.

Results and Discussion: The findings indicate that approximately 60% of farmers have adopted at least one CE practice, leading to a productivity increase of up to 25% compared to conventional methods. Additionally, CE adoption has proven to improve income stability and farmer welfare. However, barriers such as limited access to technology and funding reduce broader adoption of sustainable practices.

Research Implications: This study recommends government and institutional support through training, technology access, and financial incentives to accelerate CE adoption. It provides actionable reccomendations for policymakers and stakeholders to support the broader adoption of circular economy practices in agriculture.

Originality/Value: The originality of this research lies in its focus on the adoption of circular economy principles within the specific context of sustainable agriculture in Magelang District, an area with unique agricultural challenges and potential. This research combines empirical data on productivity and welfare impacts with qualitative insights into local adoption barriers and drivers. By integrating these aspects, the study provides a novel perspective on implementing sustainable agricultural practices tailored to the region’s socioeconomic and environmental conditions.
Diksi Dan Gaya Bahasa pada Naskah Pidato Presiden Soekarno
Authors: Hardianto Musa , Widayati Wahyu , Sucipto Sucipto 
Published: December 2024

Dalam penelitian ini, peneliti menganalisis diksi dan gaya bahasa pada pidato Presiden Soekarno. Tujuan dari penelitian ini adalah untuk mendeskripsikan penggunaan diksi dan gaya bahasa pada pidato Presiden Soekarno. Penelitian ini bersifat deskriptif kualitatif. Metode yang digunakan adalah analisis isi. Sumber data berupa dokumen berupa pidato Presiden Soekarno. , yaitu: (1) reduksi data; (2) penyajian data; (3) menarik kesimpulan. Hasil yang didapat adalah jenis diksi dan gaya bahasa yang terjadi dalam pidato Presiden Soekarno. Pilihan kata-kata dan gaya bahasa dalam iklan kampanye digunakan untuk menarik pendengar / simpati masyarakat untuk mewujudkan gagasan kebangsaan. Dalam penelitian ini, diksi yang paling banyak digunakan adalah kata abstrak dan kata konkret. Ini karena dalam pidato Presiden Soekarno banyak yang mengungkapkan program, visi, misi berupa gagasan atau gagasan yang menjadi indikator kata abstrak Sedangkan penggunaan kata-kata konkret terjadi karena dalam teks pidato juga menyampaikan fakta-fakta di bentuk benda yang diamati. Gaya bahasa yang terkandung dalam naskah pidato berdasarkan pilihan kata meliputi gaya bahasa formal, gaya bahasa tidak resmi, dan gaya percakapan bahasa. Gaya bahasa berbasis nada mencakup gaya sederhana, gaya mulia dan kuat.Kata kunci: Kamus, Gaya Bahasa, naskah pidato
Detection of transmembrane protein 100 in breast cancer: Correlation with malignant progression and chemosensitivity
Authors: Liu Xiao , Zhang Guiqian , Zhao Ling 
Published: December 2024

Objective:
With increased incidence, breast cancer has become the most common malignant tumor in women. Transmembrane protein 100 (TMEM100) is a key factor affecting the progression of malignant tumors. The aim of the study is to examine the molecular mechanism of TMEM100 in malignant progression.

Material and Methods:
TMEM100 expression was analyzed by Western blot, immunohistochemistry, and real-time quantitative polymerase chain reaction. Cell migration and invasiveness after transfection with TMEM100 were investigated by Transwell assay. 5-ethynyl-2-deoxyuridine staining and cell colony-formation assay were utilized to the exploration of cell proliferation. Flow cytometry was adopted to detect whether TMEM100 affected the effect of Docetaxel on cell apoptosis. The effects of TMEM100 on the Ras-extracellular signal-regulated kinase (RAS/ERK) pathway were explored by Western blot assay.

Results:
Downregulated TMEM100 expression was in breast cancer tissues (P < 0.01). TMEM100 overexpression hindered the invasion (P < 0.01), migration (P < 0.01), and proliferation (P < 0.01) of breast cancer cells. Chemotherapy sensitivity of breast cancer cells to docetaxel was enhanced by TMEM100 (P < 0.01). TMEM100 inhibited Ras expression and ERK1/2 phosphorylation (P < 0.01). Furthermore, ERK agonist TertButylhydroquinone neutralized the effects of TMEM100 (P < 0.01).

Conclusion:
TMEM100 blocked malignant progression of breast cancer and enhanced docetaxel chemosensitivity by suppressing RAS/ERK pathway. These data manifested that regulation of TMEM100 expression may affect the progression of breast cancer, and its prognostic value and mechanism deserve further investigation.
Deciphering the synergistic role of tyrosyl-tRNA synthetase 1 and yes-associated protein 1: Catalysts of malignant progression in hepatocellular carcinoma
Authors: Zhou Lifang , Zhang Xin , Zhang Chongyang , Wang Yu , Zhang Jiaju , Wang Yunxia , Sui Yongbo 
Published: December 2024

Objective:
Hepatocellular carcinoma (HCC) represents a severe and aggressive malignancy with a poor prognosis, characterized by high incidences of illness and death, making it a critical issue for global health. Tyrosyl-tRNA synthetase 1 (YARS1) is known to be upregulated across various cancers and is considerably linked to tumorigenesis. However, the detailed functions and molecular mechanisms of YARS1 in HCC remain unclear. This research explores the expression of YARS1 in HCC and its role in promoting tumor progression through the yes-associated protein 1 (YAP1) pathway.

Material and Methods:
The potential role and diagnostic significance of YARS1 and YAP1 in HCC were analyzed using relevant datasets. Subsequently, we constructed HCC cell lines with stable knockdown or overexpression of YARS1. In vitro, we used Cell Counting Kit-8 and colony formation assays to examine cell proliferation, terminal deoxynucleotidyl transferase dUTP nick end labeling assays to detect apoptosis, and Transwell migration and invasion assays to assess cell metastasis. Western blotting was employed to analyze the molecular mechanisms. Finally, we developed a lung metastasis model for HCC to assess the impact of YARS1 and YAP1 on tumor spread in a living organism, as well as their interrelationship.

Results:
The findings revealed a notable increase in YARS1 expression in HCC tumors, associated with a worse prognosis. In vitro, YARS1 overexpression significantly increased HCC cell proliferation and metastasis when reducing apoptosis (P < 0.001). In addition, YARS1 overexpression accelerated HCC growth in vivo. Further experiments demonstrated that silencing YAP1 effectively reversed the effects of YARS1 on HCC cell invasion (P < 0.01), apoptosis inhibition (P < 0.01), and metastasis (P < 0.001).

Conclusion:
In summary, this research reveals that YARS1 enhances the malignant progression of HCC through the activation of the YAP1 signaling pathway. Elevated levels of YARS1 in HCC are strongly linked to poor prognosis, indicating that YARS1 might serve as a new therapeutic target for HCC. Future studies should investigate additional mechanisms of YARS1 in HCC and create targeted therapies to improve outcomes for HCC patients.
Soluble Urokinase Plasminogen Activated Receptor in Type 2 Diabetes Mellitus Patients Undergoing Coronary Artery Bypass Grafting: A Prospective Interventional Cohort Study
Authors: Prakash Mohit , Mujahid Omer Mohammed , Choudhury Minati 
Published: December 2024

Objectives:
Elevated levels of soluble urokinase plasminogen activator receptor (suPAR) increase mortality in various systemic diseases. This has been shown amply in recent literature. The primary aim of the study was to investigate that whether this increase in suPAR levels have same results in type 2 diabetes mellitus (T2DM) patients undergoing coronary artery bypass grafting (CABG). We also aimed to observe the duration of mechanical ventilation and length of stay in the intensive care unit in these patients as our secondary aim.

Materials and Methods:
Blood samples of adult patients having T2DM admitted for elective on-pump CABG surgery were collected after induction of anesthesia before skin incision (T1) and 48 h post-cardiopulmonary bypass (CPB) (T2) from the year 2022 to 2023. The study was conducted on 196 patients of either sex of age at least 18 years with T2DM with the American Society of Anesthesiologists status III to IV. Patients were randomly divided into 2 groups with alternative allocation. Patients of the study group (n = 96) were measured suPAR, high-sensitivity C-reactive protein (hsCRP), and blood sugar, while patients of the control group (n = 100) were measured hsCRP and blood sugar only. Threshold suPAR levels for predicting mortality in the immediate post-operative period were assessed through receiver operating characteristic curves and optimal values decided using Youden’s Index.

Results:
There was a significant rise in suPAR and hs-CRP levels before the start of surgery and 48 h post-CPB (P < 0.001).

Conclusion:
In patients with T2DM undergoing on-pump CABG, increased pre-bypass, and especially 48-h post-CPB, levels of suPAR and hsCRP predict more mortality.
КСИЛОТОМИЧЕСКАЯ ХАРАКТЕРИСТИКА СПИРЕИ ЗВЕРОБОЙНОЛИСТНОЙ - SPIRAEA HYPERICIFOLIA L. (ROSACEAE) ИЗ ИТУМКАЛИНСКОЙ АРИДНОЙ КОТЛОВИНЫ
Authors: Умаров М.У. , Чавчавадзе Е.С. , Сизоненко О.Ю. , Волкова С.Б. 
Published: December 2024

Изучены анатомические характеристики древесины 10 особей спиреи зверобойнолистной - Spiraea hypericifolia L. (сем. Rosaceae) из Итумкалинской аридной котловины (Восточный Кавказ). Отмечены её структурные особенности, количественные параметры и изменчивость гистологических элементов. По степени изменчивости в пределах образца древесины выделены три группы признаков - с низким (12 признаков из 18), средним (4) и очень высоким (2) уровнем варьирования. Изменчивость большинства признаков (за исключением плотности сосудов, объема многорядных лучей, суммарного объема лучевой ткани и объема порозности древесины) в переделах одного местообитания выше, нежели внутри образца древесины. Многовариантность проявления количественных признаков, способность их варьирования, наряду со сложившимся набором качественных ксилотомических признаков, расширяя экологическую амплитуду вида, позволяют ему поселяться в различных биотопах аридной котловины.
Anatomical characteristics of wood of 10 individuals of Spiraeahypericifolium - Spiraea hypericifolia L. were studied. (Rosaceae) from the Itumkalinsky arid basin (Eastern Caucasus). Marked by its structural features and quantitative parameters and the variability of the histological elements. According to the degree of variability within the wood sample, three groups of characteristics are identified - with a low (12 out of 18 features), medium (4) and very high (2) level of variation. The variability of most features (with the exception of vascular density, multi-row ray volume, total ray tissue volume, and wood porosity volume) in one habitat is higher than within a wood sample. The multivariance of quantitative traits, their ability to vary, along with the existing set of qualitative xylotomic traits, expanding the ecological amplitude of the species, allow it to settle in various biotopes of the arid basin.
ГОРНЫЕ ЛАНДШАФТЫ ВОСТОЧНОГО КАВКАЗА: СОВРЕМЕННОЕ СОСТОЯНИЕ И ПЕРСПЕКТИВЫ ОСВОЕНИЯ (НА ПРИМЕРЕ ЧЕЧЕНСКОЙ РЕСПУБЛИКИ)
Authors: Гуня А.Н. , Петрушина М.Н. , Колбовский Е.Ю. , Гайрабеков У.Т. , Петров Л.А. , Эльмурзаев Р.С. , Серитханов С.М. 
Published: December 2024

В работе представлены результаты VI Северо-Кавказской комплексной экспедиции 2019 г., охватившей горные районы Чеченской Республики (в частности Галанчожский, ЧантыАргунский, Шаро-Аргунский и Макажойский участки). Показано, что горные территории республики, в особенности среднегорно-высокогорные, являются наименее изученными с точки зрения их ресурсного потенциала. Основная цель очередной экспедиции - изучение ландшафтной структуры и оценка ресурсного потенциала среднегорно-высокогорных территорий Чеченской Республики для обоснования перспективных ареалов и осей освоения. В ходе экспедиции собран эмпирический материал, представляющий основу для создания ландшафтных карт и схем ландшафтного планирования исследуемой территории, оценки риска склоновых процессов в ареалах перспективного освоения и состояния культурно-ландшафтных элементов, а также который послужит основой при разработке практических рекомендаций по реосвоению ареалов традиционного расселения чеченцев. Полученные результаты исследования могут быть также использованы при реализации программы социально-экономического развития Чеченской Республики и выработке рекомендаций по эффективному освоению горных территорий республики, учитывающих важность охраны природных и культурных ландшафтов.
The paper presents the results of the VI North Caucasus integrated expedition in 2019, which covered the mountainous regions of the Chechen Republic (in particular, the Galanchozhsky, ChantyArgunsky, Sharo-Argunsky and Makazhoysky sections). It is shown that the mountainous territories of the Republic, especially the mid-mountain and high-mountain ones, are the least studied in terms of their resource potential. The main goal of the next expedition is to study the landscape structure and assess the resource potential of the mid-mountain and high-altitude territories of the Chechen Republic in order to substantiate promising areas and axes of development. During the expedition, empirical material was collected, which is the basis for creating landscape maps and landscape planning schemes of the studied territory, assessing the risk of slope processes in areas of prospective development and the state of cultural and landscape elements, and which will serve as a basis for developing practical recommendations for re-development of areas of traditional settlement of Chechens. The obtained research results can also be used in the implementation of the program of socio-economic development of the Chechen Republic and the development of recommendations for the effective development of mountain territories of the Republic, taking into account the importance of protecting natural and cultural landscapes.
ОЦЕНКА ПОДВЕРЖЕННОСТИ ТЕРРИТОРИЙ РЕСПУБЛИКИ ИНГУШЕТИЯ И ЧЕЧЕНСКОЙ РЕСПУБЛИКИ ОПАСНЫМ ПРИРОДНЫМ ПРОЦЕССАМ
Authors: Кюль Е.В. 
Published: December 2024

Дана комплексная численная оценка распространения основных типов опасных процессов (снежные лавины, сели, оползни, обвалы и осыпи) на исследуемой территории. Оценка проводится картографическим методом на основе разработанной автором методики. На первом этапе оценивается изученность территории по проблеме исследований, на втором - освоенность (по типу землепользования), на третьем - собственно подверженность, т. е. степень проявления опасных процессов.
A comprehensive numerical assessment of the distribution of the main types of dangerous processes (snow avalanches, mudslides, landslides and scree) in the study area is given. The assessment is carried out using a cartographic method based on the methodology developed by the author. At the first stage, the knowledge of the territory in the study of the problem is evaluated, at the second-development (land use), at the third-the actual impact, i. e. the degree of development of dangerous processes.
РОСТ СТРЕКОЗ (ODONATA) НА ПРЕИМАГИНАЛЬНЫХ СТАДИЯХ
Authors: Козьминов С.Г. , Кетенчиев Х.А. , Хуранова Р.М. , Шантукова Ж.Г. 
Published: December 2024

Построение математических моделей служит изучению и прогнозированию роста личинок стрекоз. Для моделирования роста из комплекса морфологических и линейных параметров использовалась длина тела. По длине тела на каждой стадии, методом наименьших квадратов, получены две аппроксимирующие функции (модели): линейная (модель №1) и параболическая (модель №2), описывающие рост стрекоз на преимагинальной стадии. Выявлено, что модель №1 более точна для личинок младших стадий, а модель №2 - старших стадий. Данные модели позволяют с высокой степенью достоверности определить стадию развития.
The construction of mathematical models serves to study and predict the growth of dragonfly larvae. To model growth from a complex of morphological and linear parameters, body length was used. By the length of the body at each stage, using the least squares method, two approximating functions (models) were obtained: linear (model №1) and parabolic (model №2), which describe the growth of dragonflies at the preimaginal stage. It was revealed that model 1 is more accurate for the larvae of the younger stages, and model 2 - of the older stages. These models allow a high degree of certainty to determine the stage of development.
СОСТАВ И СТРУКТУРА ДОМИНАНТНЫХ КОМПЛЕКСОВ ЖУКОВ ЖУЖЕЛИЦ В УРБОЦЕНОЗАХ (НА ПРИМЕРЕ ГРОЗНОГО)
Authors: Автаева Т.А. 
Published: December 2024

Приводятся результаты многолетних исследований путей формирования карабидофауны Грозного. Дается оценка состава и структуры доминантных комплексов жужелиц на участках с разной степенью антропогенного воздействия. Видовой состав карабидофауны Грозного включает 99 видов. Приводится данные по количественным и качественным показателям биоразнообразия урбанизированных территорий. В статье сделан расчет индексов доминирования, которые позволяют оценить доминирование и биоразнообразие изученных территорий. Полученные данные могут быть использованы в биомониторинге городской среды.
The results of many years of research on the formation of the carabidofauna of Grozny are presented. The composition and structure of dominant complexes of ground beetles in areas with varying degrees of anthropogenic impact are estimated. The species composition of the carabidofauna of Grozny includes 99 species. Data on quantitative and qualitative indicators of the biodiversity of urbanized territories are presented. The article calculates the dominance indices, which allow us to assess the dominance and biodiversity of the studied territories. The obtained data can be used in biomonitoring of the urban environment.
ВОЗДЕЙСТВИЕ НЕФТИ И НЕФТЕПРОДУКТОВ НА ГЕОЛОГИЧЕСКУЮ СРЕДУ И РЕКОМЕНДАЦИИ ПО МИНИМИЗАЦИИ ТЕХНОГЕНЕЗА
Authors: Гайрабеков У.Т. , Усманов А.Х. 
Published: December 2024

В статье отмечено, что в процессе хранения нефти и нефтепродуктов в наземных и подземных нефтехранилищах происходит испарение паров углеводородов и утечка нефтепродуктов из технологического оборудования нефтяного комплекса, что приводит к загрязнению окружающей среды. Проведён анализ воздействия объектов хранения нефти и нефтепродуктов на отдельные компоненты природной среды. Дана оценка загрязнения геологической среды г. Грозного в результате длительного воздействия нефтепромышленного комплекса. Предложены мероприятия по минимизации техногенного воздействия на подземные воды и очистке геологической среды г. Грозного от остаточного загрязнения.
The article notes that during the storage of oil and oil products in surface and underground oil storage facilities, hydrocarbon vapors evaporate and oil products leak from the processing equipment of the oil complex, which leads to environmental pollution. The analysis of the impact of storage facilities for oil and oil products on individual components of the natural environment has been carried out. An assessment of the pollution of the geological environment of Grozny as a result of the long-term impact of the oil industry complex is given. Measures are proposed to minimize the technogenic impact on groundwater and clean up the geological environment of Grozny from residual pollution.