bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge, attitude and practice regarding COVID-19 among healthcare workers in Chitwan, Nepal
Authors: Nepal Richa , Sapkota Kalyan , Adhikari Kalidas , Paudel Pramod , Adhikari Bhojraj , Paudyal Nabin , Sapkota Kiran , Nepal Rhishikesh 
Published: May 2020

Abstract
Background

COVID-19 is a viral respiratory disease that was recently recognized in humans. The number of COVID-19 cases has been gradually increasing in Nepal. The objective of this study was to evaluate knowledge, attitude and practice regarding COVID-19 among healthcare workers in Chitwan, one of the districts located in central Nepal.
Methods

It was a cross-sectional study conducted among healthcare workers from various health institutions located in Chitwan district of Nepal. A self-reported questionnaire was circulated online. Bivariate analyses were done using Spearman’s correlation coefficient, Pearson’s chi square test, and student’s t test as appropriate, whereas multivariate analyses were done using linear regression models.
Results

A total of 353 responses were analyzed, out of which 47% were nurses, 28.9% were doctors, 11.6% were health assistants, 2% were certified medical assistants, and the remaining 10.5% were categorized as others. The majorities were females (58.9%), were in the age group of 16–29 years (67.1%) and had work experience of less than 5 years (62%). The majority of healthcare workers obtained good to moderate knowledge and practice scores (n = 82.15%, 83.57%, respectively) and had positive attitude scores (n = 90.93%). Mean score values were 21.65 ± 4.71 out of 33 in knowledge section, 8.07 ± 1.49 out of 13 in attitude section and 13.89 ± 5.33 out of 20 in practice section. Mean knowledge and practice scores were significantly associated with job descriptions of healthcare workers (p value – 0.000, 0.007, respectively) with highest mean knowledge scores among doctors (23.70 ± 4.48) and highest mean practice scores among health assistants (15.10 ± 3.61). Higher practice scores (ß = 0.626) and infection prevention training (ß = 1.467) were significantly associated with higher knowledge scores; higher knowledge (ß = 1.366) and higher practice scores (ß = 0.110) were significantly associated with higher attitude scores; and higher knowledge scores (ß = 0.308) and higher attitude scores (ß = 0.265) were significantly associated with higher practice scores.
Conclusion

The majority of healthcare workers from Chitwan, Nepal, had good to moderate knowledge and practice scores and had a positive attitude toward COVID-19. There was a significant association between knowledge, attitude and practice scores regarding COVID-19 among healthcare workers.
A comparison of sleep habits and electronic media usage among Japanese children: a cross-sectional study
Authors: Horiuchi Fumie , Oka Yasunori , Kawabe Kentaro , Ueno Shu-ichi 
Published: May 2020

Abstract
Background Children are increasingly exposed to electronic media, which can potentially influence sleep habits. Few studies have investigated how children’s life patterns affect their sleep habits and electronic media usage. This study aimed to elucidate differences in sleep habits and electronic media usage among 18-month and 42-month old children attending nursery schools or kindergartens or staying at home.Methods We included 183 18-month-old children (boys, n = 93; girls, n = 90) and 215 42-month-old children (boys, n = 104; girls, n = 111) who underwent health check-ups. Data concerning sleep habits and electronic media usage time were obtained by caregivers and compared using the chi-square test, Mann–Whitney U-test, and Bonferroni–Dunn post hoc analysis.Results At 18 months old, children attending nursery school had significantly earlier wake times on weekdays and shorter sleep duration on weekends than children staying at home, although there were no significant differences in electronic media usage. There were no significant differences in sleep duration among 42-month-old children attending nursery schools, kindergartens, or staying at home; however, children attending kindergarten demonstrated a higher use of portable and home video games.Conclusion Different life patterns affected electronic media usage in preschool children, especially those attending kindergarten. Particular attention should be paid to the higher usage of electronic media devices by kindergarten-attending children, although they slept for the same amount of time as other preschool children. Future studies are required to assess the content of electronic games and the ways in which preschool children use their time.
ANÁLISE JURÍDICA DO DESENVOLVIMENTO CONSTITUCIONAL COM ENFOQUE NO POVO INDÍGENA TAPEBA
Authors: OLIVEIRA Tiê Tófoli de , MELO FILHO Renato Luís 
Published: May 2020

Atualmente o povo Tapeba encontra-se dividido em 12 aldeias, todas dentro da área demarcada pelo Relatório Circunstanciado de Identificação e Delimitação da Terra Indígena (RECID) de 2013, localizadas na região de Caucaia distrito do município de Fortaleza: Sobradinho; Ponte; Capoeira; Trilho; Jandaiguaba; Capuan, Jardim do Amor, Aldeia dos Cacos (Coité); Lagoa I; Lagoa II, Lameirão e Lagoa das Bestas. A área declarada é de 5,2 mil hectares, o que equivale a 4,31% do território total do município. De acordo com o último censo (2014), a população indígena se encontra com cerca de 6651 índios. Atualmente eles têm sua área declarada pelo estado brasileiro e aguardam a FUNAI (Fundação Nacional do Índio) fazer a licitação para executar a demarcação física da terra. Vale ressaltar que mediante a atual política do Governo Federal a FUNAI vem sofrendo constante processo de sucateamento. Neste momento o povo Tapeba aguarda a mobilização desta fundação para que o seu território seja devidamente demarcado conforme decreto nº1775/96. Processo que já dura mais de 30 anos, o que vai contra o disposto no artigo nº67 da constituição federal de 1988.
New Orodispersible Mini Tablets of Enalapril Maleate by Direct Compression for Pediatric Patients
Authors: Ortega Claudia A. , Favier Laura S. , Cianchino Valeria A. , Cifuente Diego A. 
Published: May 2020

Background:
In many countries, hypertension in the pediatric population is considered a
serious risk of mortality and morbidity. In this respect, it is central to design and develop new pharmaceutical
forms for pediatric patients with hypertension. The development of Orodispersible Mini-Tablets
(ODMTs) for pediatric use has gained importance in recent years. Therefore, regulations for developing
suitable and palatable dosage forms for pediatric patients have been established by WHO authorities.

Objective:
This study aimed to design and develop orodispersible mini tablets of enalapril maleate
(EnM ODMTs) for pediatric use.

Methods:
Five pharmaceutical formulations (A, B, C, D and E, shown in Table 1) were designed. The
effects of different co-processed excipients and active pharmaceutical ingredients at different doses
were studied. Lactose co-processed excipients selected were the following: Tablettose® 80, Microce-
Lac® 100 and StarLac®. The micromeritic properties for all the physical mixtures were examined. The
mini tablets were obtained by direct compression. Quality control parameters were determined in accordance
with US Pharmacopeia.

Results:
Three OMDTs with StarLac® showed good results of hardness, flow ability and fast disintegration.
The formulation with 0.1 mg of enalapril maleate presented the best results for the official parameters
of hardness (4.0 kp), friability (< 1%), disintegration time (28 s), drug content uniformity (103.6
%), and wetting time (23 s).

Conclusion:
The three OMDTs with StarLac® showed good quality parameters, according to official
requirements. Formulation A exhibited the best wetting time, complying with the dose recommended
for pediatric patients. This formulation could be considered eligible for being manufactured at industrial
scale.
Analysis and Validation of Differentially Expressed MicroRNAs with their Target Genes Involved in GLP-1RA Facilitated Osteogenesis
Authors: Wang Na , Li Yukun , Liu Sijing , Gao Liu , Liu Chang , Bao Xiaoxue , Xue Peng 
Published: May 2020

Background:
Recent studies revealed that the hypoglycemic hormone, glucagon-like
peptide-1 (GLP-1), acted as an important modulator in osteogenesis of bone marrow derived
mesenchymal stem cells (BMSCs).

Objectives:
The aim of this study was to identify the specific microRNA (miRNA) using
bioinformatics analysis and validate the presence of differentially expressed microRNAs with their
target genes after GLP-1 receptor agonist (GLP-1RA) administration involved in osteogenesis of
BMSCs.

Methods:
MiRNAs were extracted from BMSCs after 5 days’ treatment and sent for highthroughput
sequencing for differentially expressed (DE) miRNAs analyses. Then, the expression
of the DE miRNAs was verified by the real-time RT-PCR analyses. Target genes were predicted,
and highly enriched GOs and KEGG pathway analysis were conducted using bioinformatics
analysis. For the functional study, two of the target genes, SRY (sex determining region Y)-box 5
(SOX5) and G protein-coupled receptor 84 (GPR84), were identified.

Results:
A total of 5 miRNAs (miRNA-509-5p, miRNA-547-3p, miRNA-201-3p, miRNA-201-5p,
and miRNA-novel-272-mature) were identified and differentially expressed among groups. The
expression of miRNA-novel-272-mature was decreased during the osteogenic differentiation of
BMSCs, and GLP-1RA further decreased its expression. MiRNA-novel-272-mature might interact
with its target mRNAs to enhance osteogenesis. The lower expression of miRNA-novel-272-
mature led to an increase in SOX5 and a decrease in GPR84 mRNA expression, respectively.

Conclusions:
Taken together, these results provide further insights to the pharmacological properties of GLP-1RA
and expand our knowledge on the role of miRNAs-mRNAs regulation network in BMSCs’ differentiation.
Repurposing of Alexidine Dihydrochloride as an Apoptosis Initiator and Cell Cycle Inhibitor in Human Pancreatic Cancer
Authors: Kasikci Ezgi , Aydemir Esra , Yogurtcu Bekir M. , Sahin Fikrettin , Bayrak Omer F. 
Published: May 2020

Background:
Highly aggressive and resistant to chemotherapy, pancreatic cancers are the fourth
leading cause of cancer-related deaths in the western world. The absence of effective chemotherapeutics is leading
researchers to develop novel drugs or repurpose existing chemicals. Alexidine Dihydrochloride (AD), an
orally bioavailable bis-biguanide compound, is an apoptosis stimulating reagent. It induces mitochondrial damage
by inhibiting a mitochondrial-specific protein tyrosine phosphatase, PTPMT1. The aim of this study was to
test AD as a novel compound to induce apoptosis in a human pancreatic adenocarcinoma cell lines, Panc-1,
MIA PaCa-2, AsPC-1, and Psn-1.

Methods:
After the IC50 value of the AD was determined by cytotoxicity assay, apoptosis was observed by a
variety of methods, including the detection of early apoptosis marker Annexin V and the proteomic profile
screening by apoptosis array. Multicaspase and mitochondrial depolarization were measured, and changes in the
cell cycle were analyzed.

Results:
AD is found to initiate apoptosis by activating the intrinsic pathway and inhibit the cell cycle in pancreatic
cancer cell lines.

Conclusions:
In conclusion, considering its anti-cancer properties and bioavailability, Alexidine dihydrochloride
can be considered as a potential candidate against pancreatic adenocarcinomas.
Pre-Chemistry Concepts and Medical Therapy among Ancient Physicians through the Pre-Socratic Philosophers
Authors: Santacroce Luigi , Bottalico Lucrezia , Haxhirexha Kastriot , Topi Skender , Charitos Ioannis A. 
Published: May 2020

Background:
Chemistry as experimental science began in the seventeenth century, when it
began moving away from being one of the alchemical doctrines and toward analyzing matter and its
transformations using scientific methods. Previously, the ancient Pre-Socratic philosophy through observation
of nature was concerned with the laws that govern the natural world and the property of matter.
Later, the Hellenistic Alexandrian culture took possession of the Hermetic doctrines of the Egyptians,
mixing them with pre-Socratic thought and Gnosticism. At this historical moment, therefore,
there was a fusion of the Greek philosophical patrimony and the Hellenistic and Alexandrian influences
on medicine. The Hermetic gnosis evolved over time to become alchemy and then to usher in the
birth of chemical science. Many doctors were wandering philosophers who dealt with cosmogony to
understand the body and diseases and to discover new healing drugs for treatment, and thus they were
the first chemist therapists.

Methods:
The influence of ancient physicians through the pre-Socratic philosophy for these prochemical
theories and practice has been researched through ancient texts, so these texts have been referenced
to determine the legacy of paleo-chemicals doctrines.

Results:
The study of various texts in particular from the Pre-Socratic age and the eminent physicians
underline that, despite a different approach to the cosmogonic concepts of nature and the matter, the
medicine of that age had an important influence on chemistry as an experimental science, especially
concerning therapy with drugs.

Conclusions:
The Pre-Socratic philosophers have influenced the medical practice and guided it toward
the concept of the properties of matter for medical treatment and an understanding of the causes of
diseases.
Giemsa Staining of Some Nano-formulations on Neuroblastoma Cell Line
Authors: Nigam Kuldeep , Dang Shweta 
Published: May 2020

Background:
Nano-formulations of various drugs and natural compounds are becoming
popular day by day. A number of cosmetic, medicinal and herbal products are formulated using
nano-carriers. However, one of the concerns using these carriers is the alteration in morphology of
cell by using such particles or droplets.

Methods:
In the present work, Giemsa staining was used to study the morphological changes on
mammalian Neuro-2a cell line upon treatment with prepared capsaicin loaded nanoemulsion
(Caps-NE), baclofen loaded poly(lactic-co-glycolic acid) nanoparticles (Bcf-PLGA-NPs) and
lamotrigine loaded poly(lactic-co-glycolic acid) nanoparticles (Ltg-PLGA-NPs). Caps-NE, Bcf-
PLGA-NPs and Ltg-PLGA-NPs, along with their respective aqueous drug counterparts, were
examined for visible morphological changes at their corresponding reported maximum plasma
concentration (Cmax) and 10xCmax values.

Results:
Microscopic images showed that drug loaded nanoemulsion/nanoparticles showed
comparable cell viability and exhibited lesser cytotoxicity than the available aqueous drug forms at
both the concentrations.

Conclusion:
The prepared formulations can be used as potentially safer option as compared to
their aqueous counterparts.
Traditional Uses, Phytochemistry, Pharmacology and Anticancer Activity
of Açaí (Euterpe oleracea Mart): A Narrative Review
Authors: da Silva Marcos Antonio Custódio Neto , do Desterro Soares Brandão Nascimento Maria , de Carvalho João Ernesto 
Published: May 2020

Background:
Euterpe oleracea Mart (açaí) is traditionally used as antidiarrheal, kidney and liver infections
and as antimalarial.

Methods:
A review on Euterpe oleracea Mart was carried out in different databases, such as PubMed, Medline, Scielo,
Herbal Medicine, as well as dissertations, theses, and books.

Results:
The literature shows the anticancer potential of açaí in different e cancer models. Regarding phytochemical
composition, the literature shows greater amount of polyphenols, especially anthocyanins.

Conclusions:
The different uses of Euterpe oleracea Mart have been demonstrated by pharmacological and
phytochemical studies, with the great amount of polyphenols, found in açaí, being pointed out as the main responsible
for its anticancer activity.
Association of BMI and Sport Activity Habits With Dysmenhorea
Authors: Khotimah Khusnul , Jauzak RR Rhetno Arobiatul , Nurunniyah Siti , Maharani Oktaviana , Wahyuningsih Wahyuningsih 
Published: May 2020

<p><strong>Abstract</strong></p><p><em>Pain during menstruation or primary dysmenorrhea is the most common gynecological complaint and experienced by many women, especially in adolescence or puberty. On average more than 50% of women in each country experience primary dysmenorrhea. As many as 55% of productive age women in Indonesia experience dysmenorrhea. Although dysmenorrhea is a common complaint about adolescents, dysmenorrhea can disrupt the activities and productivity of adolescents, so that if it is not prevented or not handled properly it can result in a decrease in the quality of life and productivity of adolescents who are the next generation. Several factors that influence the incidence of dysmenorrhea are the age of the woman, age of menarche, nutritional status, stress and exercise habits. Based on these factors, Body Mass Index (BMI) and sport activity habits are factors of the healthy habits that are very useful for improving health status in general and specifically reproductive health. Knowing the relationship between Body Mass Index (BMI) and sport activity habits and the incidence of dysmenorrhea in adolescents The study was an observational study with a cross-sectional approach. All respondents numbered 142 students, experiencing menarche at a normal age. The highest frequency of menarche (mode) is at the age of 12 years as many as 50 respondents (35.2%). A respondent with a normal BMI category there are 81 respondent (57%), 44 (31%) respondent have underweight BMI category and 17 (35%) was obese. Ninety-three respondents or 69.5% have sport activity habits, 49 (34.5%) were not used to exercise. Respondents who experienced dysmenorrhea were 120 respondents (84.5%) and 22 respondents (15.5%) did not experience dysmenorrhea. BMI is not associated with dysmenorrhea incidence with P-Value = 0,07. While sport activity habits are significantly associated with dysmenorrhea in high school students with a p-value = 0.01 &lt;α (0.05), CI = 95%, and a strong Contingency Coefficient with a value of 0.621</em>.</p>
PEMANFAATAN VIDEO YOUTUBE DALAM PENINGKATAN MOTIVASI BELAJAR SISWA INSAN LITERA
Authors: Farhatunnisya Aisyah 
Published: May 2020

Abstract This research is motivated by the fact about the low motivation to learn in students and the rise of the use of YouTube among students or adolescents. This research was conducted at the clear saguling foundation, a foundation that engages in social affairs and helps the welfare of the community around the Citarum river located in Jl. Cianjur, cihampelas village, west bandung district in this foundation which is related to what is meant by human beings in litera. The cornerstone of the theory used in this study is the theory of the use of YouTube and learning motivation theory. The purpose of this study is to study the motivation of YouTube applications to increase student motivation. The method used is to use qualitative methods with descriptive methods. The technique of receiving data through participant observation and interviews. Litera human students with a total of 11 students and 11 respondents from the respondents selected five people as a research sample. litera.Abstrak Penelitian ini di latar belakangi oleh adanya fakta tentang rendahnya motivasi belajar pada siswa dan maraknya penggunaan youtube di kalangan siswa atau remaja.Penelitian ini dilakukan di yayasan bening saguling foundation yayasan yang bergerak di bidang sosial dan bertujuan untuk mensejahterakan masyarakat sekitar sungai citarum yang terletak di jl.babakan cianjur desa cihampelas kabupaten bandung barat di yayasan tersebut mempunyai sekolah yang berbasis alam yang bernama insan litera.Landasan teori yang digunakan dalam penelitian ini yaitu teori pemanfaatan youtube dan teori motivasi belajar.Tujuan dari penelitian ini yaitu untuk mengetahui pengaruh aplikasi youtube dapat meningkatkan motivasi belajar siswa.Metodeyang di gunakan yaitu dengan pendekatan kualitatif dengan metode deskriptif.Teknik pengumpulan data melalui observasi dan dan menyebarkan kuosioner kepada para partisipan yaitu siswa insan litera dengan jumlah siswa 11 orang dan dari responden sebanyak 11 orang di pilih lima orang sebagai sampel penelitianHasil dari penelitian ini yaitu dapat diketahui bahwa pemanfaatanvideo youtube dapat meningkatan motivasi belajar siswa insan litera.
Authors: Nelvarita Nelvarita BR 
Published: May 2020

ABSTRAK
Inovasi pembelajaran ini berawal dari kecemasan siswa dalam menghadapi Ujian Nasional Kelas XII IPS MAN 1 Kota Padang Panjang. Pada mata pelajaran Geografi. Inovasi ini bertujuan untuk membantu peningkatan hasil belajar Geografi dan memotifasi aktifitas belajar siswa dalam belajar dan menyelesaikan soal soal Ujian Nasional dengan menggunakan media pembelajaran MOGE 630/Monopoli Geografi. Inovasi ini dilaksanakan di kelas XII IPS MAN 1 Kota Padang Panjang. Teknik pengumpulan data dengan observasi, dokumentasi, tes dan kuis. Analisis data yang dilakukan pada penelitian ini adalah penyajian data dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa penggunaan media pembelajaran Monopoli Geografi mampu mengatasi kecemasan siswa dalam menghadapi Ujian Nasional hal ini terlihat dari hasil belajar Geografi di kelas XII IPS MAN 1 Padang Panjang.mengalami peningkatan ketuntasan belajar peserta didik dalam setiap hasil kuis, yaitu (82,46.%) Dengan menggunakan media pembelajaran MOGE 630/Monopoli Geografi siswa merasakan pembelajaran Geografi sangat seru, menyenangkan dan merasakan kasus kasus dan soal soal serta materi yang disajikan terasa ringan
Hakikat Manajemen Dakwah
Authors: Mahmud Adilah 
Published: May 2020

Abstract[English]: Da'wah in the millennial era must now include the virtual dimension and data, by developing a bi-al-oral, bi-al-hall model and hasanah want'idhah together with bi-da'wah and e-da'wah models. Because the challenges in da'wah are very wide, good Da'wah management is needed. The purpose of this study is to describe the rights of preaching management angels. This type of research is a literature study (Library Research). Da'wah management is a series of processes that run continuously in regulating or managing preaching activities to run according to plan and on target. The optimal achievement of the missionary purpose can only be realized by managing the propaganda activity. Da'wah management has 6 functions, i.e. functions as a da'wah planning which includes forecasting or prediction of future conditions and objectives or objectives; see the opportunities and relevance of the da'wah content, establish the procedures for da'wah activities, make da'wah time schedules, determine locations, and prepare funds.Abstrak[Indonesia]: Dakwah di era milenial saat ini harus mencakup dimensi maya dan data, dengan mengembangkan model dakwah bi al-lisan, bi al-hall dan mau’idhah hasanah bersama dakwah bi al-kitab dan e-dakwah. Oleh sebab tantangan dalam berdakwah sangat luas maka diperlukan manajemen dakwah yang baik. Tujuan penelitian ini adalah untuk mendeskripsikan hakaikat manajemen dakwah. Jenis penelitian ini adalah studi pustaka (Library Reseacrh). Manajemen dakwah adalah serangkaian proses yang berjalan secara berkesinambungan dalam mengatur atau memenej aktivitas dakwah agar berjalan sesuai dengan rencana dan tepat sasaran. Tercapainya tujuan dakwah secara optimal hanya dapat terwujud dengan cara memanaj aktivitas dakwah. Manajemen dakwah memiliki 6 fungsi, yaitu fungsi sebagai perencanaan dakwah yang di dalamnya mencakup forecasting atau prediksi kondisi mad’u di masa mendatang dan objectives atau tujuan; melihat peluang dan relevansi konten dakwah, menetapkan prosedur kegiatan dakwah, membuat time schedul dakwah, menentukan lokasi, dan menyiapkan dana.