bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experience with ponatinib in paediatric patients with leukaemia
Authors: Rossoff Jenna , Huynh Van , Rau Rachel E. , Macy Margaret E. , Sulis Maria L. , Schultz Kirk R. , Burke Michael J. , Athale Uma , O'Brien Maureen M. , Gregory John J. , van der Sluis Inge M. , Keller Frank G. , Zwaan Christian M. , Suttorp Meinolf , Hijiya Nobuko 
Published: January 2020

SummaryPonatinib has proven to be effective in adults with Philadelphia chromosome‐positive leukaemias, but data in paediatrics are scarce. Among paediatric patients with chronic myeloid leukaemia (n = 9) or acute lymphoblastic leukaemia (n = 12) treated with varying doses of ponatinib in 13 centres, 71% showed a decrease in disease burden after a median of three months. Ponatinib was well tolerated, with grade 3 toxicities occurring in 29% of patients. Toxicities were similar to those reported in adults, with the exception of arterial thrombotic events, which were not observed. Ponatinib has a favourable safety profile in this paediatric cohort, but dose‐finding studies are needed.
Modifiable lifestyle behaviours impact the health‐related quality of life of bladder cancer survivors
Authors: Chung Jiil , Kulkarni Girish S. , Bender Jackie , Breau Rodney H. , Guttman David , Maganti Manjula , Matthew Andrew , Morash Robin , Papadakos Janet , Jones Jennifer M. 
Published: January 2020

ObjectiveTo examine health behaviours in bladder cancer survivors including physical activity (PA), body mass index, diet quality, smoking and alcohol consumption, and to explore their relationship with health‐related quality of life (HRQoL).Subjects/Patients and MethodsCross‐sectional questionnaire packages were distributed to bladder cancer survivors (muscle‐invasive bladder cancer [MIBC] and non‐muscle‐invasive bladder cancer [NMIBC]) aged >18 years, and proficient in English. Lifestyle behaviours were measured using established measures/questions, and reported using descriptive statistics. HRQoL was assessed using the validated Bladder Utility Symptom Scale, and its association with lifestyle behaviours was evaluated using analysis of covariance (ancova) and multivariate regression analyses.ResultsA total of 586 participants completed the questionnaire (52% response rate). The mean (SD) age was 67.3 (10.2) years, and 68% were male. PA guidelines were met by 20% (n = 117) and 22.7% (n = 133) met dietary guidelines. In all, 60.9% (n = 357) were overweight/obese, and the vast majority met alcohol recommendations (n = 521, 92.5%) and were current non‐smokers (n = 535, 91.0%). Health behaviours did not differ between MIBC and NMIBC, and cancer treatment stages. Sufficient PA, healthy diet, and non‐smoking were significantly associated with HRQoL, and the number of health behaviours participants engaged in was positively associated with HRQoL (P < 0.001).ConclusionBladder cancer survivors are not meeting guidelines for important lifestyle behaviours that may improve their overall HRQoL. Future research should investigate the impact of behavioural and educational interventions for health behaviours on HRQoL in this population.
Exploring patients’ experience and perception of being diagnosed with bladder cancer: a mixed‐methods approach
Authors: Tan Wei Shen , Teo Chin Hai , Chan Delcos , Ang Kar Mun , Heinrich Malgorzata , Feber Andrew , Sarpong Rachael , Williams Norman , Brew‐Graves Chris , Ng Chirk Jenn , Kelly John ,   DETECT II trial collaborators
Published: January 2020

ObjectiveTo determine patient experience and perception following a diagnosis of non‐muscle‐invasive bladder cancer (NMIBC).Patient and methodsPatients were part of a prospective multicentre observational study recruiting patients with NMIBC for a urine biomarker study (DETECT II; ClinicalTrials.gov: NCT02781428). A mixed‐methods approach comprising: (i) the Brief Illness Perception Questionnaire (Brief‐IPQ) and (ii) semi‐structured interviews to explore patients’ experience of having haematuria, and initial and subsequent experience with a NMIBC diagnosis. Both assessments were completed at 6 months after NMIBC diagnosis.ResultsA total of 213 patients completed the Brief‐IPQ. Patients felt that they had minimal symptoms (median [interquartile range, IQR] score 2 [0–5]) and were not particularly affected emotionally (median [IQR] score 3 [1–6]) with a minimal effect to their daily life (median [IQR] score 2 [0–5]). However, they remained concerned about their cancer diagnosis (median [IQR] score 5 [3–8]) and felt that they had no personal control over the cancer (median [IQR] score 2 [2–5]) and believed that their illness would affect them for some time (median [IQR] score 6 [3–10]). A significant association with a lower personal control of the disease (P < 0.05) and a poorer understanding of the management of NMIBC (P < 0.05) was seen in patients aged >70 years. Many patients were uncertain about the cause of bladder cancer. Qualitative analysis found that at initial presentation of haematuria, most patients were not aware of the risk of bladder cancer. Patients were most anxious and psychologically affected between the interval of cystoscopy diagnosis and transurethral resection of bladder tumour (TURBT). Following TURBT, most patients were positive about their cancer prognosis.ConclusionPatients with NMIBC have a poor perception of disease control and believe that their disease will continue over a prolonged period of time. This is particularly more pertinent in the elderly. Patients are most psychologically affected during the interval between cancer diagnosis following cystoscopy and TURBT. Health awareness about bladder cancer remained poor with a significant number of patients unaware of the causes of bladder cancer. Psychological support and prompt TURBT following bladder cancer diagnosis would help improve the mental health of patients with NMIBC.
Cathelicidin‐related antimicrobial peptide protects against ischaemia reperfusion‐induced acute kidney injury in mice
Authors: Pan Li‐Long , Liang Wenjie , Ren Zhengnan , Li Chunqing , Chen Yong , Niu Wenying , Fang Xin , Liu Yanyan , Zhang Ming , Diana Julien , Agerberth Birgitta , Sun Jia 
Published: January 2020

Background and PurposeDespite recent advances in understanding its pathophysiology, treatment of acute kidney injury (AKI) remains a major unmet medical need, and novel therapeutic strategies are needed. Cathelicidin‐related antimicrobial peptide (CRAMP) with immunomodulatory properties has an emerging role in various disease contexts. Here, we aimed to investigate the role of CRAMP and its underlying mechanisms in AKI.Experimental ApproachThe human homologue LL‐37 and CRAMP were measured in blood samples of AKI patients and in experimental AKI mice respectively. Experimental AKI was induced in wild‐type and CRAMP‐deficient (Cnlp−/−) mice by ischaemia/reperfusion (I/R). Therapeutic evaluation of CRAMP was performed with exogenous CRAMP (5 mg·kg−1, i.p.) treatment.Key ResultsCathelicidin expression was inversely related to clinical signs in patients and down‐regulated in renal I/R‐induced injury in mice. Cnlp−/− mice exhibited exacerbated I/R‐induced renal dysfunction, aggravated inflammatory responses and apoptosis. Moreover, over‐activation of the NLRP3 inflammasome in Cnlp−/− mice was associated with I/R‐induced renal injury. Exogenous CRAMP treatment markedly attenuated I/R‐induced renal dysfunction, inflammatory response and apoptosis, correlated with modulation of immune cell infiltration and phenotype. Consistent with Cnlp−/− mouse data, CRAMP administration suppressed renal I/R‐induced NLRP3 inflammasome activation, and its renal protective effects were mimicked by a specific NLRP3 inhibitor CY‐09. The reno‐protective and NLRP3 inhibitory effects of CRAMP required the EGF receptor.Conclusion and ImplicationsOur results suggest that CRAMP acts as a novel immunomodulatory mediator of AKI and modulation of CRAMP may represent a potential therapeutic strategy.
Basement‐controlled deformation of sedimentary sequences, Anadarko Shelf, Oklahoma
Authors: Kolawole Folarin , Simpson Turko Molly , Carpenter Brett M. 
Published: January 2020

AbstractStructures rooted in the crystalline basement frequently control the deformation of the host bedrock and the overlying sedimentary sequences. Here, we elucidate the structure of the c. 2‐km deep Precambrian granitic basement in the Anadarko Shelf, Oklahoma, and how the propagation of basement faults deformed the sedimentary cover. Although the basin is foreland in origin, the gently dipping shelf sequences experienced transpressional deformation in the Late Palaeozoic. We analyse a 3‐D seismic reflection data set and basement penetrating well data in an area of 824 km2. We observe: (a) pervasive deformation of the basement by basement‐bounded interconnected mafic sills, and a system of subvertical discontinuity planes (interpreted as faults) of which some penetrate the overlying sedimentary cover; (b) three large (>10 km‐long) through‐going faults, with relatively small (<100 m) vertical separation (Vsep) of the deformed stratigraphic surfaces; (c) upward propagation of the large faults characterized by faulted‐blocks near the basement, and faulted‐monoclines in the deeper sedimentary units that transition into open monoclinal flexures up‐section; (d) cumulative along‐fault deformation of the stratigraphy exhibits systematic trends that varies with offset accrual; (e) two styles of Vsep—Depth distribution which include a unidirectional decrease of Vsep from the basement through the cover rocks (Style‐1) and a bidirectional decrease of Vsep from a deep sedimentary unit towards the basement and shallower sequences (Style‐2). We find that the basement‐driven propagation (Style‐1) shows greater efficiency of driving the fault deformation to shallower depths compared to the intrasedimentary‐driven fault nucleation and propagation (Style‐2). Our study demonstrates an evolution of cumulative Vsep trends with offset accrual on the faults, and the partial inheritance of the heterogeneous intra‐basement deformation by the sedimentary cover. This contribution provides important insight into the upward propagation of basement‐driven faulting associated with structural inheritance in contractional sedimentary basins.
Neonatal jaundice and developmental impairment among infants in Kilifi, Kenya
Authors: Magai Dorcas N. , Mwaniki Michael , Abubakar Amina , Mohammed Shebe , Gordon Anne L. , Kalu Raphael , Mwangi Paul , Koot Hans M. , Newton Charles R. 
Published: January 2020

AbstractBackgroundNeonatal jaundice (NNJ) is common in sub‐Saharan Africa (SSA), and it is associated with sepsis. Despite the high incidence, little has been documented about developmental impairments associated with NNJ in SSA. In particular, it is not clear if sepsis is associated with greater impairment following NNJ.MethodsWe followed up 169 participants aged 12 months (57 cases and 112 controls) within the Kilifi Health Demographic Surveillance System. The diagnosis of NNJ was based on clinical laboratory measurement of total serum bilirubin on admission, whereas the developmental outcomes were assessed using the Developmental Milestones Checklist and Kilifi Development Inventory.ResultsThere were significant differences between the cases and controls in all developmental domains. Cases scored lower in language functioning (mean [M] = 6.5, standard deviation [SD] = 4.3 vs. M = 8.9, SD = 4.6; p < .001); psychomotor functioning (Mdn = 23, interquartile range [IQR] = 17–34 vs. Mdn = 31.0, IQR = 22.0–44.0; Mann–Whitney U = 4,122, p = .002); and socio‐emotional functioning ([Mdn = 30.0, IQR = 27.0–33.0 vs. Mdn = 34.0, IQR = 30.0–37.0], Mann–Whitney U = 4,289, p < .001). There was no evidence of association between sepsis and psychomotor (rpb = −.2, p = .214), language (rpb = −.1, p = .510), and socio‐emotional functioning (rpb = .0, p = .916). Significant and medium to large portions of the variance (34–64%) in the developmental outcomes among children who survived NNJ were associated with home birth, low maternal education, and feeding problems during the first days of life.ConclusionsNNJ is associated with developmental impairments in the early childhood years; however, NNJ associated with sepsis does not lead to more severe impairment. Prenatal and postnatal care services are needed to reduce the negative impact of NNJ for children from low resourced settings.
Patterns of Risk and Protective Factors Among Alaska Children: Association With Maternal and Child Well‐Being
Authors: Austin Anna E. , Gottfredson Nisha C. , Halpern Carolyn T. , Zolotor Adam J. , Marshall Stephen W. , Parrish Jared W. , Shanahan Meghan E. 
Published: January 2020

This study used population‐representative data to examine associations of risk and protective factor patterns among Alaska Native/American Indian (AN/AI; N = 592) and non‐Native (N = 1,018) children with maternal and child outcomes at age 3 years. Among AN/AI children, a high risk/moderate protection class was associated with child developmental risk and mothers being less likely to feel comfortable asking for help or knowing where to go for parenting information compared to a low socioeconomic status/high protection class. Among non‐Native children, a moderate risk/high protection class was associated with child developmental risk and mothers being less likely to feel comfortable asking for help compared to a low risk/high protection class. Results provide insight on the intersection of risk and protective factors among Alaska families.
Identifying conservation priorities in a defaunated tropical biodiversity hotspot
Authors: Tilker Andrew , Abrams Jesse F. , Nguyen An , Hörig Lisa , Axtner Jan , Louvrier Julie , Rawson Benjamin M. , Nguyen Hoa Anh Quang , Guegan Francois , Nguyen Thanh Van , Le Minh , Sollmann Rahel , Wilting Andreas 
Published: January 2020

AbstractAimUnsustainable hunting is leading to widespread defaunation across the tropics. To mitigate against this threat with limited conservation resources, stakeholders must make decisions on where to focus anti‐poaching activities. Identifying priority areas in a robust way allows decision‐makers to target areas of conservation importance, therefore maximizing the impact of conservation interventions.LocationAnnamite mountains, Vietnam and Laos.MethodsWe conducted systematic landscape‐scale surveys across five study sites (four protected areas, one unprotected area) using camera‐trapping and leech‐derived environmental DNA. We analysed detections within a Bayesian multispecies occupancy framework to evaluate species responses to environmental and anthropogenic influences. Species responses were then used to predict occurrence to unsampled regions. We used predicted species richness maps and occurrence of endemic species to identify areas of conservation importance for targeted conservation interventions.ResultsAnalyses showed that habitat‐based covariates were uninformative. Our final model therefore incorporated three anthropogenic covariates as well as elevation, which reflects both ecological and anthropogenic factors. Conservation‐priority species tended to found in areas that are more remote now or have been less accessible in the past, and at higher elevations. Predicted species richness was low and broadly similar across the sites, but slightly higher in the more remote site. Occupancy of the three endemic species showed a similar trend.Main conclusionIdentifying spatial patterns of biodiversity in heavily defaunated landscapes may require novel methodological and analytical approaches. Our results indicate that to build robust prediction maps it is beneficial to sample over large spatial scales, use multiple detection methods to increase detections for rare species, include anthropogenic covariates that capture different aspects of hunting pressure and analyse data within a Bayesian multispecies framework. Our models further suggest that more remote areas should be prioritized for anti‐poaching efforts to prevent the loss of rare and endemic species.
Effects of Argentine ants (Hymenoptera: Formicidae) on myrmecophilous lycaenid butterfly, Narathura bazalus (Lepidoptera: Lycaenidae), in western Japan
Authors: Ikenaga Nobuhiro , Touyama Yoshifumi , Kameyama Takeshi , Ito Fuminori 
Published: January 2020

AbstractEffects of the invasive Argentine ant, Linepithema humile (Mayr), on a myrmecophilous butterfly, Narathura bazalus (Hewiston), were investigated in the field in western Japan. Larvae of N. bazalus were attended by workers of Argentine ants in invaded parks and of ten native and one cosmopolitan ant species in uninvaded parks. The abundance of eggs and larvae were not significantly different between invaded and uninvaded parks. Pupal weight and parasitized ratio by tachinid flies were also not different between the two types of parks. These results indicate that the role of Argentine ants for the butterfly might be almost equivalent to the native ants.
Remembrance–Toward Righteousness and Reparations
Authors: Carruthers Iva E. 
Published: January 2020

AbstractThis article explores “remembrance” as the first part of a planned three‐part paper titled “Remembrance, Righteousness and Reparations,” intended as a conceptual framework and spirit guide of accompaniment for the World Council of Churches’ pilgrimage of healing, justice, and peace. This first part focuses on remembrance to counter the dis‐membering, trauma, and woundedness inflicted by systems of acts of White supremacy, racism, patriarchy, and male privilege. Parts two and three of this paper offer righteousness and reparations as additional conceptual frameworks and spirit guides: righteousness to recentre and deepen our understanding of justice in a world fraught with human suffering, violence, and evil; and reparations to covenant and bind a process of truth‐telling, reckoning, and reconciliation in the face of the consequences and legacies of the transatlantic slave trade system upon people of African descent.
New regulatory mechanism‐based inhibitors of aspartate transcarbamoylase for potential anticancer drug development
Authors: Lei Zhen , Wang Biying , Lu Zhifang , Wang Nan , Tan Hongwei , Zheng Jimin , Jia Zongchao 
Published: January 2020

Aspartate transcarbamoylase (ATCase) is a key enzyme which regulates and catalyzes the second step of de novo pyrimidine synthesis in all organisms. Escherichia coli ATCase is a prototypic enzyme regulated by both product feedback and substrate cooperativity, whereas human ATCase is a potential anticancer target. Through structural and biochemical analyses, we revealed that R167/130's loop region in ATCase serves as a gatekeeper for the active site, playing a new and unappreciated regulatory role in the catalytic cycle of ATCase. Based on virtual compound screening simultaneously targeting the new regulatory region and active site of human ATCase, two compounds were identified to exhibit strong inhibition of ATCase activity, proliferation of multiple cancer cell lines, and growth of xenograft tumors. Our work has not only revealed a previously unknown regulatory region of ATCase that helps uncover the catalytic and regulatory mechanism of ATCase, but also successfully guided the identification of new ATCase inhibitors for anticancer drug development using a dual‐targeting strategy.DatabaseStructure data are available in Protein Data Bank under the accession numbers: 6KJ7 (G166P ecATCase), 6KJ8 (G166P ecATCase‐holo), 6KJ9 (G128/130A ecATCase), and 6KJA (G128/130A ecATCase‐holo).
The effects of season, sex, age and weather on population‐level variation in the timing of activity in Eurasian Blue TitsCyanistes caeruleus
Authors: Schlicht Lotte , Kempenaers Bart 
Published: January 2020

All birds sleep and many do so in a specific location, the roost. Thus, every day each individual needs to decide when to go to (enter) and leave the roosting place. This determines the timing of activity, a trait shaped by both natural and sexual selection. Despite its importance in a variety of contexts, including foraging, predation, mating success and parental care, variation in the timing of activity has rarely been studied. Here, we describe this variation in a population of Eurasian Blue TitsCyanistes caeruleusroosting in nestboxes using data collected over 7 years. We investigate seasonal changes in the start and end of activity and assess to what extent these parameters are sex‐ and age‐specific and affected by weather. We show that the start of activity is relatively constant in relation to sunrise during winter but undergoes drastic changes during the breeding season. The end of activity is markedly later relative to sunset in mid‐winter and is also strongly influenced by breeding behaviour. Females generally start their activity later and end it earlier than males. The duration of daily activity is shorter during periods of rain and longer when temperatures are relatively high for the time of year.
PANEL DATA HEDONICS: ROSEN'S FIRST STAGE AS A “SUFFICIENT STATISTIC”
Authors: Banzhaf H. Spencer 
Published: January 2020

AbstractTraditional cross‐sectional estimates of hedonic price functions can recover marginal willingness to pay for characteristics, but face endogeneity problems for estimating nonmarginal welfare measures. This article shows that when panel data on household demands are available, one can construct a second‐order approximation to nonmarginal welfare measures using only the first‐stage marginal prices. With repeated cross sections of product prices, the measure can be set identified or, under a single‐crossing restriction, point identified. Bounds also can be constructed when there are mobility costs. Finally, a variant remains valid when individual preferences shift over time.
Pressure‐induced anomalous behavior of thaumasite crystal
Authors: Moon Juhyuk , Kim Seungchan , Bae Sungchul , Clark Simon Martin 
Published: January 2020

AbstractThis work investigated the structural responses of thaumasite crystal, an important phase to understand the structural integrity of concrete‐based structures, using synchrotron‐based X‐ray diffraction and first‐principles calculations. The 100 peak was immediately diffused upon the contact of pressure‐transmitting medium, but regenerated under subsequent pressurization. Under high pressure, it showed complex nonlinear responses; lattice parameters a and b became stiffer first (between 1.06 and 2.32 GPa) then lattice parameter c became significantly incompressible (beyond 2.32 GPa). The densification of hydrogen bond network in the channels surrounded by calcium silicate columns and the interaction between the network and the medium caused the first nonlinear response and completely weakened the periodicity of lattice parameters a and b (beyond 5.37 GPa). However, this amorphization phenomenon did not leave a permanent damage on the crystal, leading to the reshaping of the weakened crystallinity upon the release of pressure. Simulation results further elucidated the compressive mechanism of thaumasite crystal. It confirmed that deformation due to pressure mainly took place in the channel space, thus strengthening the hydrogen bonds. It also suggested a potential symmetry breaking of hexagonal structure that makes the stiffness characteristics of the crystal highly anisotropic under pressure.