bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic recombination and diversity of sapovirus in pediatric patients with acute gastroenteritis in Thailand, 2010–2018
Authors: Kumthip Kattareeya , Khamrin Pattara , Ushijima Hiroshi , Chen Limin , Li Shilin , Maneekarn Niwat 
Published: February 2020

Background
Human sapovirus (SaV) is an etiologic agent of acute gastroenteritis (AGE) in all age groups worldwide. Genetic recombination of SaV has been reported from many countries. So far, none of SaV recombinant strain has been reported from Thailand. This study examined the genetic recombination and genotype diversity of SaV in children hospitalized with AGE in Chiang Mai, Thailand.

Methods
Stool samples were collected from children suffering from diarrhea who admitted to the hospitals in Chiang Mai, Thailand between 2010 and 2018. SaV was detected by RT-PCR and the polymerase and capsid gene sequences were analysed.

Results
From a total of 3,057 samples tested, 50 (1.6%) were positive for SaV. Among positive samples, SaV genotype GI.1 was the most predominant genotype (40%; 20/50), followed by GII.1 and GII.5 (each of 16%; 8/50), GI.2 (14%; 7/50), GIV.1 (4%; 2/50), and GI.5 (2%; 1/50). In addition, 4 SaV recombinant strains of GII.1/GII.4 were identified in this study (8%; 4/50).

Conclusions
The data revealed the genetic diversity of SaV circulating in children with AGE in Chiang Mai, Thailand during 2010 to 2018 and the intragenogroup SaV recombinant strains were reported for the first time in Thailand.
Status and Distribution of Indian Peafowl (Pavo cristatus) in the South Coimbatore, Tamilnadu, India
Authors: Yogeshwari M. , Varunprasath K. 
Published: February 2020

The Indian Peafowls (Pavo crisatus) is Least Concern (LC) category on Red list and Schedule I species as per Wildlife Protection Act (1972) in India. Indian Peafowl (Pavo crisatus) population status and distribution was studied in South Coimbatore district especially in Polllachi area from August 2017 to January 2018. The study carried out in 13 villages in South Coimbatore including Nchavelampalayam, Chandrapuram, Kollupalayam, Chellampalayam, Marampudungigoundanur, Athanaripalayam, Kotturmalayandipattinam, Vallakundapuram, Vedasanthur, Kanchampalayam, Sangampalayam, Angalankuruchi, Paramadaiyur Village etc. From the present study, 405 direct sighting consists of 1283 Peafowls in 13 villages were recorded. Based on the Group wise of Peafowls showed that Mixed group(MIG) contain 50.37% followed by Male female group(MFG) stand for 40.74%, Female chick group(FCG) contains 4.19%, Female group(FG) with the percentage of 3.95%, and Male group(MG) which constitute of 0.74% were recorded. Based on Peafowls classification, Females Peafowls consist of 59.85% followed by 17.77% of Peacock, 13.09% Peafowls chicks, 9.27% sub adults Peafowls were observed. According to the Peafowls habitat, the study area categorized into mixed forest (MFL) habitat, Agricultural Land (AL) and Coconut farmland (CFL). Maximum of Peafowls observed in Coconut farmland (CFL) comprised of 44.33% followed by the mixed forest land (MFL) habitat consists of 36.20% and very low in Agricultural Land (AL) 19.45% of Peafowls were occupied. As a result of habitat thrashing, absence of predation and easy accessibility of food, climate change influence of Peafowls interested in countryside villages.
The feasibility of using exoskeletal‐assisted walking with epidural stimulation: a case report study
Authors: Gorgey Ashraf S. , Gill Satinder , Holman Matthew E. , Davis John C. , Atri Roozbeh , Bai Ou , Goetz Lance , Lester Denise L. , Trainer Robert , Lavis Timothy D. 
Published: February 2020

AbstractSpinal cord epidural stimulation (SCES) exhibits a rehabilitation potential of restoring locomotion in individuals with spinal cord injury (SCI). However, this is linked to an intensive rehabilitation locomotion approach, which is impractical to apply among a large clinical SCI population. We, hereby, propose a rehabilitation approach of using SCES to enhance motor control during exoskeletal‐assisted walking (EAW). After 24 sessions (12 weeks) of EAW swing assistance decreased from 100% to 35% in a person with C7 complete SCI. This was accompanied by 573 unassisted steps (50% of the total number of steps). Electromyographic pattern improved during EAW, reflecting the subject’s ability to rhythmically activate paralyzed muscles. Rate perceived exertion increased during EAW with SCES compared to stepping without SCES. These preliminary findings suggest that using SCES with EAW may be a feasible rehabilitation approach for persons with SCI.
New phenotype of DCTN1‐related spectrum: early‐onset dHMN plus congenital foot deformity
Authors: Tian Wo‐Tu , Liu Li‐Hua , Zhou Hai‐Yan , Zhang Chao , Zhan Fei‐Xia , Zhu Ze‐Yu , Chen Sheng‐Di , Luan Xing‐Hua , Cao Li 
Published: February 2020

AbstractObjectiveTo describe the clinical and genetic features of two patients with different phenotypes due to various Dynactin 1 (DCTN1) gene mutations and further explore the phenotype–genotype relationship.MethodsPatient 1 is a 23‐year‐old man with congenital foot deformity and life‐long distal muscle weakness and atrophy. Patient 2 is a 48‐year‐old woman with adult‐onset progressive weakness, lower limbs atrophy, and pyramid bundle signs. Electrophysiology test showed normal nerve conduction velocity of both patients and neurogenic changes in needle electromyography. Open sural nerve biopsy for Patient 1 showed slight loss of myelinated nerve fibers. Both patients were performed with whole‐exome sequencing followed by functional study of identified variants.ResultsTwo mutations in DCTN1 gene were identified in Patient 1 (c.626dupC) and Patient 2 (c.3823C>T), respectively. In vitro, the wild type mostly located in cytoplasm and colocalized with α‐tubulin. However, c.626dupC tended to be trapped into nuclear and the c.3823C>T formed cytoplasmic aggregates, both losing colocalization with α‐tubulin. Western blotting showed a truncated mutant with less molecular weight of c.626dupC was expressed.InterpretationWe identify two novel DCTN1 mutations causing different phenotypes: (1) early‐onset distal hereditary motor neuropathy plus congenital foot malformation and (2) amyotrophic lateral sclerosis, respectively. We provide the initial evidence that foot developmental deficiency probably arises from subcellular localizing abnormality of Dynactin 1, revealing DCTN1‐related spectrum is still expanding.
Recent Advances in Host–Guest Self‐Assembled Cyclodextrin Carriers: Implications for Responsive Drug Delivery and Biomedical Engineering
Authors: Wankar Jitendra , Kotla Niranjan G. , Gera Sonia , Rasala Swetha , Pandit Abhay , Rochev Yury A. 
Published: February 2020

AbstractThis Review is an overview of the unique characteristics of cyclodextrin in forming an inclusion complex via host–guest noncovalent interactions. The modification of cyclodextrin advances its application as a pharmaceutical solubilizer, fabrication of functional molecular machines such as polyrotaxane, polypseudorotaxane, and polycatenanes and grafting of cyclodextrin with different linear, branched chain polymers. The different stimuli‐based supramolecular assemblies involving cyclodextrin as a key mediator with linked triggering responses on payload release is highlighted. In addition, the applications of cyclodextrin in diagnostic imaging and medical devices is briefly demonstrated. Cyclodextrin is a relatively low cost, biocompatible, biodegradable, and highly explored material with low toxicity for drug formulation, drug delivery, and wide varieties of other biomedical applications such as those in medical devices fabrication, biosensor, tissue engineering, and bio‐imaging. The toxicological profile of cyclodextrin is well established and safe for human consumption in food and medicine.
Dual Passivation of Perovskite Defects for Light‐Emitting Diodes with External Quantum Efficiency Exceeding 20%
Authors: Fang Zhibin , Chen Wenjing , Shi Yongliang , Zhao Jin , Chu Shenglong , Zhang Ji , Xiao Zhengguo 
Published: February 2020

AbstractSolution‐processed metal halide perovskites (MHPs) have attracted much attention for applications in light‐emitting diodes (LEDs) due to their wide color gamut, high color purity, tunable emission wavelength, balanced electron/hole transportation, etc. Although MHPs are very tolerant to defects, the defects in solution‐processed perovskite LEDs (PeLEDs) still cause severe nonradiative recombination and device instability. Here, molecular design of additives for dual passivation of both lead and halide defects in perovskites is reported. A bi‐functional additive, 4‐fluorophenylmethylammonium‐trifluoroacetate (FPMATFA), is synthesized by using a simple solution process. The TFA anions and FPMA cations can bond with undercoordinated lead and halide ions, respectively, resulting in dual passivation of both lead and halide defects. In addition, the bulky FPMA group can constrain the grain growth of 3D perovskite, enhancing electron–hole capture rates and radiative recombination rates. As a result, high‐performance PeLEDs with a peak external quantum efficiency reaching 20.9% and emission wavelength at 694 nm are achieved using formamidinium‐cesium lead iodide‐bromide (FA0.33Cs0.67Pb(I0.7Br0.3)3). Furthermore, the operational lifetime of PeLEDs is also greatly improved due to the low trap density in the perovskite film.
Chiral Reaction Field with Thermally Invertible Helical Sense that Controls the Helicities of Conjugated Polymers
Authors: Akagi Kazuo , Yamashita Tomohiro , Horie Keita , Goh Munju , Yamamoto Masaharu 
Published: February 2020

AbstractA chiral reaction field with thermally invertible helical sense enables control of the helicity of the reaction product, which is a central challenge in asymmetric synthesis that has yet to be overcome. A novel chiral compound comprising two types of chiral moieties with opposite helicities and temperature dependences is synthesized; this compound is added as a chiral dopant to a mixture of nematic liquid crystals to prepare a chiral nematic liquid crystal (N*‐LC). The N*‐LC containing the chiral dopant exhibits thermally invertible helicity to yield left‐ and right‐handed helical senses at low and high temperatures, respectively. Interfacial polymerization of acetylene is achieved in the N*‐LC by modulating the temperature. Helical polyacetylenes (H‐PAs) that are synthesized at low (−12 °C) and high (28 °C) temperature show right‐ and left‐handedness, respectively, in terms of the fibrils, fibril bundles, and spiral morphology. In addition, the helical sense of H‐PA is opposite that of the N*‐LC because of the peculiar polymerization mechanism for acetylene in the N*‐LC. The current N*‐LC is the first chiral reaction field that has not only the thermally invertible helical sense but also the chemical functions and stability needed to serve as the medium for polymer reactions.
Maximizing Friction by Passive Jamming
Authors: Tramsen Halvor T. , Filippov Alexander E. , Gorb Stanislav N. , Heepe Lars 
Published: February 2020

AbstractMany solutions for getting grip on varying substrates exist in nature and in technical applications, but they fail on substrate geometries they are not specifically designed for. A novel passive load‐dependent system is developed that creates high friction forces on a large variety of substrates: the granular media friction pad. With an elastic membrane encasing granular media, it reversibly undergoes the jamming transition only by varying the normal load. Here, the friction performance on different substrates is shown and the underlying physical mechanisms in a numerical simulation are investigated.
Bioinspired Helical Triboelectric Nanogenerators for Energy Conversion of Motion
Authors: Li Xiucheng , Mu Jiliang , He Jian , Fan Xueming , Zhang Qiyuan , Hou Xiaojuan , Geng Wenping , Zhang Wendong , Chou Xiujian 
Published: February 2020

AbstractCollecting energy from body movements to supply power for equipment is an important method to rapidly develop wearable intelligent equipment. This method places high requirements, such as being lightweight and stable, on a nanogenerator. Herein, a bioinspired helical triboelectric nanogenerator (BH‐TENG) that realizes energy acquisition through the intensity and frequency of body movement is designed based on the helical structure of DNA. The helical structure facilitates more contact areas and provides increased stability to complete the power generation process than the simple structure with planar electrodes and functional layers in the same volume. It is found that when the frequency is 4 Hz and the impact load is 50 N, the output current reaches 17 µA and the voltage reaches 300 V with a charge transfer capacity of 371 nC. When the BH‐TENG is fitted in the sole of a shoe, it can light 120 LEDs when a subject is walking. After simple rectification output and capacitance matching, the BH‐TENG is verified to work independently and stably for 20 min to provide power for small digital thermometer. The above experiments show the advantages of the BH‐TENG in acquiring body motion energy.
Dual‐Tunable Structural Colors from Liquid‐Infused Aerogels
Authors: Wang Zhen , Zou Weizhi , Zhao Han , Guo Jing , Qian Zhenchao , Li Rui , Ouyang Liangqi , Li Xiaofeng , Dong Haixia , Zhao Ning , Xu Jian 
Published: February 2020

AbstractHerein, dual‐tunable structural colors generated from liquid‐infused, robust silsesquioxane aerogels due to the specific light scattering by the aerogel skeleton in liquids with matching refractive indices, are reported. The colors are tunable by changing the temperature and the composition of the liquid that roots from the coherence between the colors and the refractive index of the infused liquid. The finding provides new insights and tools for constructing structural colors and light management. It also opens applications of stimuli‐responsive smart windows, displays, and sensors. Taking advantage of the penetrable light of selected wavelength, the 3D structures of aerogel skeletons are reconstructed by an optical method, which provides a facile alternative approach to characterizing aerogel structure and will be instrumental to the understanding of the relationship between skeleton structure and mechanical property of porous 3D structures.
Scalable Synthesis of Green Fluorescent Carbon Dot Powders with Unprecedented Efficiency
Authors: Wei Jian‐Yong , Lou Qing , Zang Jin‐Hao , Liu Zhi‐Yu , Ye Yang‐Li , Shen Cheng‐Long , Zhao Wen‐Bo , Dong Lin , Shan Chong‐Xin 
Published: February 2020

AbstractIt still remains a challenge to synthesize solid‐state carbon dots (CDs) with high emission efficiency; a hurdle that has hindered the application of CDs in many fields. In this work, efficient fluorescent CDs have been prepared through a one‐step microwave‐assisted heating method. Experimental data show strong green emissions produced from the CD powders (CDPs), carrying an unprecedented 75.9% quantum yield due to both spatial confinement and defect reduction with the introduction of NaOH. Likewise, CDPs prepared in tens of grams at 3 min time intervals also achieve high production yields at ≈69.8%. Specifically, for white light‐emitting devices (WLEDs) with color coordinates of 0.366 and 0.366, when fabricated by coating CDPs with commercial red‐emitting phosphors on blue‐emitting LED chips, it is found that the luminous efficiency reached 52.3 lm W−1. Besides, the WLEDs exhibit a high color rendering index of 93.5 and show great color chromatic stability even at a driving current of 200 mA.
Improving Gender Participation in Agricultural Technology Adoption in Asia: From Rhetoric to Practical Action
Authors: Rola‐Rubzen Maria Fay , Paris Thelma , Hawkins Jacob , Sapkota Bibek 
Published: February 2020

AbstractNew and improved agricultural technologies can transform lives, particularly the lives of smallholder farm households in Asia who are highly dependent on agriculture. However, there are large gender disparities in the adoption of such technologies. Many barriers exist in achieving gender equity in access to and adoption of agricultural technologies, from sociocultural norms and deeply rooted beliefs about gender roles to lack of agency and lack of resources to implement policies. Notwithstanding these barriers, the case for promoting gender‐inclusive adoption of technology is strong. In this paper, we outline the rationale for improving women's adoption of agricultural technology and discuss the pitfalls of failing to include women in the technology‐adoption agenda. We then explore the policy implications and suggest various strategies that promote gender‐equitable outcomes and that can be used to mainstream gender in agricultural technology adoption efforts to convert policy statements to practical and effective actions.
Congenital heart defects in Noonan syndrome: Diagnosis, management, and treatment
Authors: Linglart Léa , Gelb Bruce D. 
Published: February 2020

AbstractNoonan syndrome is a pleomorphic genetic disorder, in which a high percentage of affected individuals have cardiovascular involvement, most prevalently various forms of congenital heart disease (i.e., pulmonary valve stenosis, septal defects, left‐sided lesions, and complex forms with multiple anomalies). Care includes attentiveness to several comorbidities, some directly impacting cardiac management (bleeding diatheses and lymphatic anomalies). More than 50% of patients with Noonan syndrome harbor PTPN11 pathogenic variation, which results in hyperactivation of RAS/mitogen‐activated protein kinase signaling. Several other disease genes with similar biological effects have been uncovered for NS and phenotypically related disorders, collectively called the RASopathies. Molecular diagnosis with gene resequencing panels is now widely available, but phenotype variability and in some cases, subtlety, continues to make identification of Noonan syndrome difficult. Until genetic testing becomes universal for patients with congenital heart disease, alertness to Noonan syndrome's broad clinical presentations remains crucial. Genotype–phenotype associations for Noonan syndrome enable better prognostication for affected patients when a molecular diagnosis is established. We still lack Noonan syndrome‐specific treatment; however, newly developed anticancer RAS pathway inhibitors could fill that gap if safety and efficacy can be established for indications such as pulmonary valve stenosis.
Inverted papilloma is associated with greater radiographic inflammatory disease than other sinonasal malignancy
Authors: Papagiannopoulos Peter , Tong Ching Lick , Kuan Edward C. , Tajudeen Bobby A. , Yver Christina M. , Kohanski Michael A. , Cohen Noam A. , Kennedy David W. , Palmer James N. , Adappa Nithin D. 
Published: February 2020

BackgroundThe pathogenesis of inverted papilloma (IP) has not been fully elucidated. However, chronic paranasal sinus inflammation has been anecdotally observed in sites distant from tumor obstruction in IP patients, suggesting an association between inflammation and IP tumorigenesis. This study assesses the association between sinonasal inflammation found in IP and compares this to the level of inflammation observed in other sinonasal tumors.MethodsA retrospective chart review was performed identifying patients with unilateral IP. Pertinent clinical data was obtained and comparative analysis of preoperative computed tomography (CT) imaging and histopathology was performed. A sample of unilateral, sinonasal, non‐IP and non–squamous cell tumors was used as the control. The Lund‐Mackay scoring system was used to assess radiologic sinonasal inflammation both ipsilateral and contralateral to the tumor.ResultsSeventy‐one patients were included; 58.9% of patients with IP had evidence of contralateral sinusitis at the time of presentation. In the control group, 26.7% had evidence of contralateral inflammation. When comparing contralateral sinus inflammation between the 2 study groups, the IP patients had significantly higher Lund‐Mackay scores than the control group (1.9 vs 0.26, p < 0.001). When comparing ipsilateral sinus inflammation, no significant difference was found in Lund‐Mackay scores (5.44 vs 4.00, p < 0.184).ConclusionIn this study, unilateral IPs were associated with a higher level of contralateral sinonasal inflammation when compared to control. This suggests that IP may be associated with inflammation that is independent of obstruction by the tumor. Further studies are needed to better understand the temporal relationship between chronic inflammation and tumorigenesis.
Stereoinvertive C–C Bond Formation at the Boron‐Bound Stereogenic Centers through Copper‐Bipyridine‐Catalyzed Intramolecular Coupling of α‐Aminobenzylboronic Esters
Authors: Yoshinaga Yukako , Yamamoto Takeshi , Suginome Michinori 
Published: February 2020

AbstractEnantiospecific intramolecular Suzuki–Miyaura‐type coupling with α‐(2‐halobenzoylamino)benzylboronic esters to give 3‐substituted isoindolinones is achieved by using copper catalysts with 2,2′‐bipyridine‐based achiral ligands. Enantioenriched α‐aminobenzylboron reactants bearing a hydrogen atom at the boron‐bound stereogenic carbons undergo stereoinvertive coupling in the presence of a 6‐phenyl‐2,2′‐bipyridine ligand with high enantiospecificity. α‐Aminobenzylboronates bearing fully substituted boron‐bound stereogenic centers also gave the 3,3‐disubstituted isoindolinones with stereospecific stereochemical inversion in the presence of simple 2,2′‐bipyridine as a ligand.
Planar AIEgens with Enhanced Solid‐State Luminescence and ROS Generation for Multidrug‐Resistant Bacteria Treatment
Authors: Ni Jen‐Shyang , Min Tianliang , Li Yaxi , Zha Menglei , Zhang Pengfei , Ho Chun Loong , Li Kai 
Published: February 2020

AbstractPlanar luminogens have encountered difficulties in overcoming intrinsic aggregation‐caused emission quenching by intermolecular π‐π stacking interactions. Although excited‐state double‐bond reorganization (ESDBR) can guide us on designing planar aggregation‐induced emission (AIE) luminogens (AIEgens), its mechanism has yet been elucidated. Major challenges in the field include methods to efficiently restrict ESDBR and enhance AIE performance without using bulky substituents (e.g., tetraphenylethylene and triphenylamine). In this study, we rationally developed fluoro‐substituent AIEgens with stronger intermolecular H‐bonding interaction for restricted molecular motions and increased crystal density, leading to decreased nonradiative decay rate by one order of magnitude. The adjusted ESDBR properties also show a corresponding response to variation in viscosity. Furthermore, their aggregation‐induced reactive oxygen species (ROS) generations have been discovered. The application of such planar AIEgen in treating multidrug‐resistant bacteria has been demonstrated in a mouse model. The relationship between ROS generation and distinct E/Z‐configurational stacking behaviors have been further understood, providing a design principle for synthesizing planar AIEgen‐based photosensitizers.