bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of algorithms for evaluating performance of flood simulation models with satellite-derived flood
Authors: Surwase Tushar , Manjusree P. , Prakash Sachin , Kuntla Saikiran 
Published: July 2020

Abstract
Flood inundation simulation models are widely used for simulating severe events of flood, generating hazard maps, risk assessment, and to identify flood vulnerable locations. It is important to assess the degree of accuracy of flood model results as these results may be one of the triggering parameters considered in developing flood hazard maps, flood mitigation policies, and land using planning where multi-criteria analysis is approached. In the present study, an algorithm is developed in order to know the performance of flood models by validating it with flood footprints extracted from synthetic aperture radar (SAR) images using multi-segmentation and Otsu's thresholding technique. Evaluation of the performance of the model is based on two best fit criteria called F1 and F2. For this, HEC-RAS model is used for simulating the severe event of flood witnessed in Mahanadi River in Odisha stretching between Tikarpara and Mundali during September 2008. Three simulations were made by considering three different Manning's roughness for river and floodplain. The model gives appreciable results and best fit F1 = 0.85 and F2 = 0.74 was found for Manning's roughness 0.020.
Chemical disinfectants of COVID-19: an overview
Authors: Al-Sayah Mohammad Hussein 
Published: July 2020

Abstract
The outbreak of coronavirus (COVID-19) has led to a broad use of chemical disinfectants in order to sterilize public spaces and prevent contamination. This paper surveys the chemicals that are effective in deactivating the virus and their mode of action. It presents the different chemical classes of disinfectants and identifies the chemical features of these compounds that pertain to their biocidal activity, relevant to surface/water disinfection.
Effect of temperatures and alternating anoxic/oxic sequencing batch reactor (SBR) operating modes on extracellular polymeric substances in activated sludge
Authors: Sun Hongwei , Cai Chenjian , Chen Jixue , Liu Chunyu , Wang Guangjie , Li Xiaoqiang , Zhao Huanan 
Published: July 2020

Abstract
In order to investigate the effect of temperatures and operating modes on extracellular polymeric substances (EPS) contents, three sequencing batch reactors (SBRs) were operated at temperatures of 15, 25, and 35 °C (R15 °C, R25 °C, and R35 °C, respectively), with two SBRs operated under alternating anoxic/oxic conditions (RA/O and RO/A, respectively). Results showed that higher contents of tightly bound EPS (TB-EPS) and total EPS appeared in R15 °C, while loosely bound EPS (LB-EPS) dominated in R35 °C. In all three kinds of EPS (LB-EPS, TB-EPS and total EPS) assessed, protein was the main component in R15 °C and R25 °C, while polysaccharides dominated in R35 °C. Moreover, compared with RO/A, RA/O was favorable for the production of the three kinds of EPS. Furthermore, three kinds of EPS and their components were augmented during the nitrification process, while they declined during the denitrification process under all conditions except for R35 °C.
ATF4, DLX3, FRA1, MSX2, C/EBP-ζ, and C/EBP-α Shape the Molecular Basis of Therapeutic Effects of Zoledronic Acid in Bone Disorders
Authors: Marofi Faroogh , Choupani Jalal , Solali Saeed , Vahedi Ghasem , Hassanzadeh Ali , Gharibi Tohid , Hagh Majid F. 
Published: July 2020

Objective:
Zoledronic Acid (ZA) is one of the common treatment choices used in various boneassociated
conditions. Also, many studies have investigated the effect of ZA on Osteoblastic-Differentiation
(OSD) of Mesenchymal Stem Cells (MSCs), but its clear molecular mechanism(s) has remained to be understood.
It seems that the methylation of the promoter region of key genes might be an important factor involved
in the regulation of genes responsible for OSD. The present study aimed to evaluate the changes in the mRNA
expression and promoter methylation of central Transcription Factors (TFs) during OSD of MSCs under treatment
with ZA.

Materials and Methods:
MSCs were induced to be differentiated into the osteoblastic cell lineage using routine
protocols. MSCs received ZA during OSD and then the methylation and mRNA expression levels of target
genes were measured by Methylation Specific-quantitative Polymerase Chain Reaction (MS-qPCR) and
real-time PCR, respectively. The osteoblastic differentiation was confirmed by Alizarin Red Staining and the
related markers to this stage.

Results:
Gene expression and promoter methylation level for DLX3, FRA1, ATF4, MSX2, C/EBPζ, and
C/EBPa were up or down-regulated in both ZA-treated and untreated cells during the osteodifferentiation process
on days 0 to 21. ATF4, DLX3, and FRA1 genes were significantly up-regulated during the OSD processes,
while the result for MSX2, C/EBPζ, and C/EBPa was reverse. On the other hand, ATF4 and DLX3 methylation
levels gradually reduced in both ZA-treated and untreated cells during the osteodifferentiation process on days 0
to 21, while the pattern was increasing for MSX2 and C/EBPa. The methylation pattern of C/EBPζ was upward
in untreated groups while it had a downward pattern in ZA-treated groups at the same scheduled time. The result
for FRA1 was not significant in both groups at the same scheduled time (days 0-21).

Conclusion:
The results indicated that promoter-hypomethylation of ATF4, DLX3, and FRA1 genes might be
one of the mechanism(s) controlling their gene expression. Moreover, we found that promoter-hypermethylation
led to the down-regulation of MSX2, C/EBP-ζ and C/EBP-α. The results implicate that ATF4, DLX3 and FRA1
may act as inducers of OSD while MSX2, C/EBP-ζ and C/EBP-α could act as the inhibitor ones. We also determined
that promoter-methylation is an important process in the regulation of OSD. However, yet there was no
significant difference in the promoter-methylation level of selected TFs in ZA-treated and control cells, a methylation-
independent pathway might be involved in the regulation of target genes during OSD of MSCs.
Interaction of a Vanadyl Schiff Base Complex with DNA and BSA: A Combination of Experimental and Computational Studies
Authors: Aliabad Hamid B. , Mohamadi Maryam , Falahati-Pour Soudeh K. , Hajizadeh Mohammad R. , Abdollahdokht Danial , Nematollahi Mohammad H. , Mahmoodi Mehdi 
Published: July 2020

Background and Purpose:Cancer is the primary cause of death in the world. Vanadium (IV) is a metal ion complex which has been proposed as a suitable candidate for cancer treatment. In this study, the interaction of the oxido-vanadium (IV) complex [VOL(bipy)] with salmon sperm DNA and Bovine Serum Albumin (BSA) was investigated through experimental and computational approaches. With the results of this experimental study, the mechanism and parameters related to the interaction of [VOL(bipy)] with DNA and BSA were determined.Materials and Methods:The kinetic interaction of DNA and BSA with [VOL(bipy)] was determined using absorption titration and fluorescence quenching, respectively. Moreover, the possible interactions were calculated by molecular docking prediction using the available software.Results:The binding constant (Kb) of the complex-DNA interaction was calculated to be 2.34×104 M-1, indicating a relatively strong interaction between the complex and DNA. It was found that the V(IV) complex interacted with DNA through the groove binding mode followed by partial intercalation into the DNA helix. The Kb values obtained for [VOL(bipy)]-BSA interaction were in the range of 1.07×103-5.82×104 M-1. The V(IV) complex was found to prefer the domain I binding pocket of BSA with the ΔGb value of -7.52 kcal/mol.Conclusion:Both experimental and computational analyses confirmed the interaction of the vanadium complex with DNA and BSA. The moderate affinity of [VOL(bipy)] for BSA indicates that this protein is a good candidate for transferring the complex.
QSAR Modeling, Molecular Docking and Molecular Dynamics Simulations Studies of Lysine-Specific Demethylase 1 (LSD1) Inhibitors as Anticancer Agents
Authors: Abdizadeh Rahman , Heidarian Esfandiar , Hadizadeh Farzin , Abdizadeh Tooba 
Published: July 2020

Background:
Background: Histone Lysine Demetylases1 (LSD1) is a promising medication to treat cancer, which
plays a crucial role in epigenetic modulation of gene expression. Inhibition of LSD1with small molecules has
emerged as a vital mechanism to treat cancer.

Objective:
In the present research, molecular modeling investigations, such as CoMFA, CoMFA-RF, CoMSIA and
HQSAR, molecular docking and Molecular Dynamics (MD) simulations were carried out on some
tranylcypromine derivatives as LSD1 inhibitors.

Methods:
The QSAR models were carried out on a series of Tranylcypromine derivatives as data set via the
SYBYL-X2.1.1 program. Molecular docking and MD simulations were carried out by the MOE software and the
SYBYL program, respectively. The internal and external predictability performances related to the generated
models for these LSD1 inhibitors were justified by evaluating cross-validated correlation coefficient (q2), noncross-
validated correlation coefficient (r2ncv) and predicted correlation coefficient (r2pred) of the training and test set
molecules, respectively.

Results:
The CoMFA (q2, 0.670; r2ncv, 0.930; r2pred, 0.968), CoMFA-RF (q2, 0.694; r2ncr, 0.926; r2pred, 0.927),
CoMSIA (q2, 0.834; r2ncv, 0.956; r2pred, 0.958) and HQSAR models (q2, 0.854; r2ncv, 0.900; r2pred, 0.728) for training
as well as the test set of LSD1 inhibition resulted in significant findings.

Conclusion:
These QSAR models were found to be perfect and strong with better predictability. Contour maps of
all models were generated and it was proven by molecular docking studies and molecular dynamics simulation that
the hydrophobic, electrostatic and hydrogen bonding fields are crucial in these models for improving the binding
affinity and determining the structure-activity relationship. These theoretical results are possibly beneficial to
design new strong LSD1 inhibitors with enhanced activity to treat cancer.
Surveillance of Noncommunicable Disease Epidemic Through the Integrated Noncommunicable Disease Collaborative Management System: Feasibility Pilot Study Conducted in the City of Ningbo, China
Authors: Li Sixuan , Zhang Liang , Liu Shiwei , Hubbard Richard , Li Hui 
Published: July 2020

Background
Noncommunicable diseases (NCDs) have become the main public health concern worldwide. With rapid economic development and changes in lifestyles, the burden of NCDs in China is increasing dramatically every year. Monitoring is a critical measure for NCDs control and prevention. However, because of the lack of regional representativeness, unsatisfactory data quality, and inefficient data sharing and utilization, the existing surveillance systems and surveys in China cannot track the status and transition of NCDs epidemic.

Objective
To efficaciously track NCDs epidemic in China, this pilot program conducted in Ningbo city by the Chinese Center for Disease Control and Prevention (CDC) aimed to develop an innovative model for NCDs surveillance and management: the integrated noncommunicable disease collaborative management system (NCDCMS).

Methods
This Ningbo model was designed and developed through a 3-level (county/district, municipal, and provincial levels) direct reporting system based on the regional health information platform. The uniform data standards and interface specifications were established to connect different platforms and conduct data exchanges. The performance of the system was evaluated based on the 9 attributes of surveillance system evaluation framework recommended by the US CDC.

Results
NCDCMS allows automatic NCDs data exchanging and sharing via a 3-level public health data exchange platform in China. It currently covers 201 medical institutions throughout the city. Compared with previous systems, automatic popping up of the report card, automatic patient information extraction, and real-time data exchange process have highly improved the simplicity and timeliness of the system. The data quality meets the requirements to monitor the incidence trend of NCDs accurately, and the comprehensive data types obtained from the database (ie, directly from the 3-level platform on the data warehouse) also provide a useful information to conduct scientific studies. So far, 98.1% (201/205) of medical institutions across Ningbo having been involved in data exchanges with the model. Evaluations of the system performance showed that NCDCMS has high levels of simplicity, data quality, acceptability, representativeness, and timeliness.

Conclusions
NCDCMS completely reshaped the process of NCD surveillance reporting and had unique advantages, which include reducing the work burden of different stakeholders by data sharing and exchange, eliminating unnecessary redundancies, reducing the amount of underreporting, and structuring population-based cohorts. The Ningbo model will be gradually promoted elsewhere following this success of the pilot project, and is expected to be a milestone in NCDs surveillance, control, and prevention in China.
Implementing Web-Based Therapy in Routine Mental Health Care: Systematic Review of Health Professionals’ Perspectives
Authors: Davies Fiona , Shepherd Heather L , Beatty Lisa , Clark Brodie , Butow Phyllis , Shaw Joanne 
Published: July 2020

Background
Web-based therapies hold great promise to increase accessibility and reduce costs of delivering mental health care; however, uptake in routine settings has been low.

Objective
Our objective in this review was to summarize what is known about health care professionals’ perceptions of the barriers to and facilitators of the implementation of web-based psychological treatments in routine care of adults in health care settings.

Methods
We searched 5 major databases (MEDLINE, EMBASE, PsycINFO, CINAHL, and the Cochrane Library) for qualitative, quantitative, or mixed-methods studies exploring health professionals’ views on computer- or internet-based psychological treatment programs. We coded included articles for risk of bias and extracted data using a prepiloted extraction sheet.

Results
We identified 29 eligible articles: 14 qualitative, 11 quantitative, and 4 mixed methods. We identified the following themes: patient factors, health professional factors, the therapeutic relationship, therapy factors, organizational and system factors, and models of care. Health professionals supported web-based therapies only for patients with relatively straightforward, low-risk diagnoses, strong motivation and engagement, high computer literacy and access, and low need for tailored content. They perceived flexibility with timing and location as advantages of web-based therapy, but preferred blended therapy to facilitate rapport and allow active monitoring and follow-up of patients. They emphasized the need for targeted training and organizational support to manage changed workflows. Health professionals were concerned about the confidentiality and security of client data for web-based programs, suggesting that clear and transparent protocols need to be in place to reassure health professionals before they will be willing to refer.

Conclusions
Without health professionals’ support, many people will not access web-based therapies. To increase uptake, it is important to ensure that health professionals receive education, familiarization, and training to support them in incorporating web-based therapies into their practice, and to design systems that support health professionals in this new way of working with patients and addressing their concerns.

Trial Registration
PROSPERO CRD42018100869; https://tinyurl.com/y5vaoqsk
Managing COVID-19 With a Clinical Decision Support Tool in a Community Health Network: Algorithm Development and Validation
Authors: McRae Michael P , Dapkins Isaac P , Sharif Iman , Anderman Judd , Fenyo David , Sinokrot Odai , Kang Stella K , Christodoulides Nicolaos J , Vurmaz Deniz , Simmons Glennon W , Alcorn Timothy M , Daoura Marco J , Gisburne Stu , Zar David , McDevitt John T 
Published: July 2020

Background
The coronavirus disease (COVID-19) pandemic has resulted in significant morbidity and mortality; large numbers of patients require intensive care, which is placing strain on health care systems worldwide. There is an urgent need for a COVID-19 disease severity assessment that can assist in patient triage and resource allocation for patients at risk for severe disease.

Objective
The goal of this study was to develop, validate, and scale a clinical decision support system and mobile app to assist in COVID-19 severity assessment, management, and care.

Methods
Model training data from 701 patients with COVID-19 were collected across practices within the Family Health Centers network at New York University Langone Health. A two-tiered model was developed. Tier 1 uses easily available, nonlaboratory data to help determine whether biomarker-based testing and/or hospitalization is necessary. Tier 2 predicts the probability of mortality using biomarker measurements (C-reactive protein, procalcitonin, D-dimer) and age. Both the Tier 1 and Tier 2 models were validated using two external datasets from hospitals in Wuhan, China, comprising 160 and 375 patients, respectively.

Results
All biomarkers were measured at significantly higher levels in patients who died vs those who were not hospitalized or discharged (P<.001). The Tier 1 and Tier 2 internal validations had areas under the curve (AUCs) of 0.79 (95% CI 0.74-0.84) and 0.95 (95% CI 0.92-0.98), respectively. The Tier 1 and Tier 2 external validations had AUCs of 0.79 (95% CI 0.74-0.84) and 0.97 (95% CI 0.95-0.99), respectively.

Conclusions
Our results demonstrate the validity of the clinical decision support system and mobile app, which are now ready to assist health care providers in making evidence-based decisions when managing COVID-19 patient care. The deployment of these new capabilities has potential for immediate impact in community clinics and sites, where application of these tools could lead to improvements in patient outcomes and cost containment.
International Political Communication in The Context of Digitalization of World Development
Authors: Belozerov V. K. 
Published: July 2020

The article is dedicated to exploring the phenomenon of international political communication, changing in the context of world development digitalization. The logic of comprehension and sequence of material presentation stem from a number of circumstances. Firstly, the modern socio- political practice of responding to digitalization is characterized by fragmentation, discreteness and incompleteness. Nevertheless, digitalization is a real phenomenon that has a political dimension, and its manifestations, consequences and exposure perspectives need scientific understanding. Furthermore, the very international political communication remains understudied. The research on communication processes is focused mainly on the domestic sphere. Consequently, the content and direction of changes in the sphere of international political communication under the influence of digitalization are not fully evaluated by the scientific community.The methodological basis of the research is the theory of political communication and realism. The disclosure of the stated topic required the use of structural and functional analysis, document analysis, comparative analysis, and performance analysis. The author derives the definition of international political communication. Based on the study of specialized literature and available examples from practice, problem clusters of international political communication are being identified and characterized, some measures of response to digitalization are being proposed. In order to assess and understand the prospects for responding to the digitalization of international political communication, attention is paid to the study and comparison of the doctrinal documents of Russia, the USA, Germany and Austria. It is substantiated that changes in the practice of international political communication in the context of digitalization will increase.
Kreativitas dalam Pendidikan Musik
Authors: Hidayatullah Riyan 
Published: July 2020

Musik merupakan hasil dari pemikiran dan proses kreatif. Karya musik diciptakan melalui ide-ide baru kepada penikmatnya. Dalam konteks pendidikan musik, kreativitas merupakan alat untuk mencapai tujuan pembelajaran musik. Strategi pembelajaran didasaran pada pemikiran untuk memancing peserta didik menumbuhkan ide-ide (divergen) dan mencari solusi (konvergen). Artikel ini mempersepsikan kreativitas sebagai sebuah alat berpikir dalam konteks pendidikan musik. Literature review digunakan sebagai metode untuk melakukan identifikasi mendalam dan kritis terhadap penelitian sebelumnya
(Aveyard, 2014). Kreativitas memberikan nilai pada kualitas pembelajaran musik melalui aktivitas berpikir yang dinamis. Mengaransemen, berimprovisasi dalam materi musik tertentu (seperti jazz), dan secara teratur mempraktikkan sight-reading adalah pola belajar yang berlandaskan kreativitas. Musik dapat dilibatkan dalam proses pembelajaran untuk membangkitkan gairah dalam belajar musik
(lihat: Ritter & Ferguson, 2017)
Składniki pokarmowe w ziarnie pszenżyta ozimego w zależności od zmianowania i technologii produkcji
Authors: JAŚKIEWICZ BOGUSŁAWA , PANASIEWICZ KATARZYNA 
Published: July 2020

Pszenżyto jest cennym zbożem paszowym o wysokiej wartości odżywczej ziarna. Celem badań było określenie wpływu zróżnicowanego udziału zbóż w strukturze zasiewów, w warunkach różnej technologii, na zawartość składników pokarmowych w ziarnie wybranych trzech odmian pszenżyta ozimego. W warunkach monokultury zbożowej ziarno pszenżyta zawierało więcej węglowodanów i włókna surowego, natomiast przy 75-procentowym udziale zbóż w strukturze zasiewów – białka ogółem, tłuszczu i popiołu surowego. Przy intensywnej technologii produkcji stwierdzono w ziarnie pszenżyta więcej białka ogółem i węglowodanów, natomiast mniej tłuszczu surowego. Zawartość popiołu i włókna surowego nie zależała od technologii produkcji. Ziarno odmian ‘Fredro’ i ‘Alekto’ średnio z lat 2012/2013, 2014/2015 i 2015/2016 zawierało podobną ilość węglowodanów, mniej ich było w ziarnie odmiany ‘Cerber’, u której jednocześnie było najwięcej popiołu surowego. Zawartość włókna surowego w ziarnie była niższa u odmian ‘Cerber’ i ‘Fredro’ niż u odmiany ‘Alekto’. Opady wpłynęły na koncentrację zawartości węglowodanów i popiołu w ziarnie pszenżyta ozimego. Przy mniejszej sumie opadów i wyższej średniej temperaturze miesięcznej otrzymano wyższą zawartość białka ogólnego, tłuszczu surowego i włókna surowego w ziarnie.