bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Integrated Inclusion Health Service for Homeless Adults in Dublin: An Observational, Descriptive Study
Authors: Siersbaek Rikke , Lawlee Ann-Marie , Dowds Joanne , Molamphy Aoife , O’Rourke Niamh , Kennedy Una , Geary Una , Moughty Adrian , Sears Jess , Sandys Vicky , Macken Lilly , Sweeney Ann-Marie , Rooney Claire , Cheallaigh Clíona Ní 
Published: January 2020

Abstract
Background: The pilot Inclusion Health Service was a multi-component intervention designed to improve outcomes for adults experiencing homelessness accessing hospital care. The objectives of this report are to describe the development and evaluation of the Inclusion Health Service. Method: Observational study reporting on a multi-component intervention including comprehensive assessment and case management of homeless adult inpatients, case management advice to emergency department- and community-based health, and social care providers and education sessions for hospital and community-based staff. Results: The Inclusion Health Service assessed and developed a comprehensive discharge plan for 262 patients admitted to the hospital. 51 weekly interagency case management meetings took place during the one-year pilot. Additional interventions included education sessions for hospital and community-based health and social care providers; case management advice to ED and community-based health providers and provision of clothes and personal hygiene items to homeless inpatients. During the intervention, declines in the rate of ED presentations and admissions for homeless adults, compared with the prior year, were observed in the participating hospital. Lengths of stay remained the same. Conclusion: An Inclusion Health assessment and integrated discharge plan are feasible and acceptable and may have reduced the need for unscheduled healthcare.
Outcomes after the conversion of metal-on-metal hip resurfacing arthroplasty to ceramic-on-ceramic total hip arthroplasty: A retrospective observational study with a mean 10-year follow-up
Authors: Yu Weiguang , Shuai Mao , Lin Jinluan , Chen Baomin , Zhao Mingdong , Zhang Chao Xin , Chen Wenli , Han Guowei 
Published: January 2020

Abstract
Background The purpose of this retrospective study was to assess clinical outcomes following failed metal-on-metal hip resurfacing arthroplasty (MoM-HRA) revised using ceramic-on-ceramic total hip arthroplasty (CoC-THA) via the direct anterior approach (DAA).Methods Data involving 112 patients (112 hips) with failed primary MoM-HRA that was revised using CoC-THA via the DAA during 2006 - 2018 were retrospectively analysed. The mean age was 54.6 years (45–63 years). Frequent surgical indications for conversion were aseptic loosening and femoral neck fracture. The primary endpoint was the Postel-Merle d’Aubigne functional score (PMA). Secondary endpoints were the major orthopaedic complication rate and serum metal ion levels (chromium and cobalt).Results The mean follow-up time was 10 years (range, 4 - 13 years). The mean PMA improved from 9 (4-14) to 16 (13-18) (p = 0.001). Six patients had undergone a re-revision intervention. Fourteen incidents of aseptic loosening and four periprosthetic fractures were observed. A consistent decline in mean serum metal ion levels was detected [chromium decreased from 36.6 μg/L (12.5-76.5 μg/L) prior to conversion to 2.6 μg/L (0.1-13.5 μg/L) at final follow-up (p = 0.001), cobalt decreased from 37.5 μg/L (6.7-93.2 μg/L) to 2.2 μg/L (1.2-18.4 μg/L) (p =0.003)].Conclusion Failed primary MoM-HRA converted to CoC-THA using the DAA yielded acceptable clinical outcomes.
Polylactide pins can effectively fix severely comminuted and unsalvageable radial head fracture: a retrospective study of 40 patients
Authors: Guo Liang , li 睿夫 , Yang Xuhui , Yu Chao , Gui Fei 
Published: January 2020

Abstract
Background The treatment of comminuted unsalvageable radial head fracture remains controversial. Open reduction and internal fixation are hard to achieve. Common techniques include radial head resection and arthroplasty. Both methods have characteristic complications. The present study aims to demonstrate the feasibility of treating unreducible radial head fractures with absorbable polylactide pins. Methods A total of 17 patients with severely comminuted Mason type III radial head fractures were treated with open reduction and internal fixation using polylactide pins and 23 with metallic implants. Patients receiving both modalities were followed-up for a mean of 15 months (standard deviation [SD]: 2.6). Radiographic analysis was conducted 2, 30, 60 and 120 days after surgery. Measurements of range of motion (ROM), disability of arm shoulder and hands, Mayo elbow performance score and Broberg and Morrey elbow score were recorded, with treatments compared using a Mann-Whitney U test. Result All fractures healed successfully. The data shows no statistical difference between the polylactide and metallic implant groups. Complications were infrequent and did not cause disability. All patients were satisfied with the surgical outcomes. Conclusion Polylactide pins can feasibly treat severely comminuted radial head fractures which are normally considered unreducible. The outcomes were similar to those of metallic implants. This technique provides an optional treatment plan in addition to resection and arthroplasty, especially for young patients that refuse that form of treatment.
Clinical and radiographic outcomes of oblique lateral lumbar interbody fusion and minimally-invasive transforaminal lumbar interbody fusion in patients with grade-1 degenerative spondylolisthesis
Authors: He Da , He Wei , Liu Yajun , Sun Yuqing , Xing Yonggang , Lang Zhao , Tian Wei 
Published: January 2020

Abstract
Background: The most effective lumbar interbody fusion (LIF) technique for degenerative spondylolisthesis remains controversial. Methods: This is a retrospective study. This comparative analysis included consecutive patients with grade-1 degenerative spondylolisthesis who underwent oblique LIF (OLIF) or minimally-invasive transforaminal LIF (MI-TLIF) at the Department of Spine Surgery, our hospital(January 2016 to August 2017). Patient satisfaction (Japanese Orthopaedic Association score), visual analog scale (VAS) scores for back and leg pain, Oswestry disability index (ODI), radiographic outcomes including anterior/posterior disc heights (ADH/PDH), foraminal height (FH), foraminal width (FW), cage subsidence, cage retropulsion and fusion rate were assessed during a 2-year follow-up. Results: The OLIF and MI-TLIF groups comprised 36 patients (age, 52.1±7.2 years; 27 women) and 45 patients (age, 48.4±14.4 years; 24 women) respectively. Satisfaction rates at 2 years exceeded 90% in both groups. The OLIF group had less intraoperative blood loss (140±36 vs. 233±62 mL), lower back pain VAS score (2.42±0.81 vs. 3.38±0.47) and ODI score (20.47±2.53 vs. 27.31±3.71) at 3 months (with trends toward lower values at 2 years), but higher leg pain VAS scores at all postoperative time points than the MI-TLIF group (all P<0.001). ADH, PDH, FD and FW improved in both groups after surgery. At 2 years, the OLIF group had a higher rate of Bridwell grade-I fusion (100% vs. 88.9%, P=0.046) and lower incidences of cage subsidence (8.33% vs. 46.67%, P<0.001) and retropulsion (0% vs. 6.67%, P=0.046). Conclusions: In patients with grade-I spondylolisthesis, OLIF was associated with less blood loss and better improvements in some clinical(VAS for back pain and ODI) and radiologic outcomes than MI-TLIF, although patients in the OLIF group had higher leg pain VAS scores than patients in the MI-TLIF group.
Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population
Authors: Li Chuanyin , Li Yaheng , Yan Zhiling , Dai Shuying , Liu Shuyuan , Wang Xia , Wang Jun , Zhang Xinwen , Shi Li , Yao Yufeng 
Published: January 2020

Abstract
Background: antigen-processing machinery molecules play crucial roles in infectious diseases and cancers. Studies have shown that variants in endoplasmic reticulum aminopeptidase (ERAP) genes can influence the enzymatic activity of ERAP proteins and are associated with the risk of cancers. In the current study, we evaluated the influence of ERAP gene (ERAP1 and ERAP2) variants on susceptibility to cervical intraepithelial neoplasia (CIN) and cervical cancer.Methods: Six single nucleotide polymorphisms (SNPs) in ERAP1 and 5 SNPs in ERAP2 were selected and genotyped in 556 CIN patients, 1072 cervical cancer patients, and 1262 healthy control individuals. Candidate SNPs were genotyped using SNaPshot assay. And the association of these SNPs with CIN and cervical cancer was analysed.Results: the results showed that allelic and genotypic frequencies of rs26653 in ERAP1 were significantly different between cervical cancer and control groups (P=0.001 and 0.004). The allelic frequencies of rs27044 in ERAP1 and rs2287988 in ERAP2 were also significantly different between control and cervical cancer groups (P=0.003 and 0.004). Inheritance model analysis showed that genotypes at rs26618, rs26653, rs27044, and rs2287988 SNPs may be associated with the risk of cervical cancer (P=0.004, 0.001, 0.003, and 0.002). Additionally, haplotype analysis results showed that the ERAP1 haplotype, rs26618T-rs26653G-rs27044C-rs30187T-rs3734016C, was associated with a lower risk of cervical cancer (P=0.001; OR=0.804, 95%CI:0.711-0.910). The ERAP2 haplotypes rs2248374A-rs2549782G-rs2287988G-rs2548538A-rs1056893T might be the risk factor of cervical cancer (P=0.009; OR=1.592, 95%CI:1.122-2.258). Haplotype rs2248374G-rs2549782T-rs2287988A-rs2548538T-rs1056893T of ERAP2 might be associated with lower risk of cervical cancer (P=0.003; OR=0.835,95%CI:0.740-0.942). Conclusion: Our results indicated that rs26653 and rs27044 in ERAP1 and rs2287988 in ERAP2 influenced susceptibility to cervical cancer.
Effect of microwave ablation treatment against hepatic malignance on serum cytokine level.
Authors: Zhao Jing , Li Qiang , Muktiali Merlin , Ren Bingjie , Hu Yingxi , Li Dapeng , Li Zhi , Li Daoming , Xie Yufeng , Tao Min , Liang Rongrui 
Published: January 2020

Abstract
BackgroundMicrowave ablation (MWA) is widely used to treat unresectable primary and secondary malignancies of the liver, and a limited number of studies indicate that ablation can cause not only necrosis at the in situ site but also an immunoreaction of the whole body. This study aimed to investigate the effects of MWA on cytokines in patients who underwent MWA against a hepatic malignancy.MethodsPatients admitted to the Oncology Department in the First Affiliated Hospital of Soochow University between June 2015 and February 2019 were selected. Peripheral blood was collected from patients with a hepatic malignancy treated with MWA. The levels of cytokines (IL-2, IFN-γ, TNF-α, IL-12 p40, IL-12 p70, IL-4, IL-6, IL-8, IL-10, and vascular endothelial growth factor (VEGF)) were detected with a MILLIPLEX® MAP Kit. The comparison times were as follows: before ablation, 24 hours after ablation, 15 days after ablation, and 30 days after ablation. Data were analyzed using a paired sample t-test and Spearman’s correlation analysis.ResultsA total of 43 patients with hepatic malignancies were recorded. There were significant differences in IL-2, IL-12 p40, IL-12 p70, IL-1β, IL-8, and TNF-α at 24 hours after MWA. Significant increases (>2-fold vs. before ablation) were observed in IL-2, IL-1β, IL-6, IL-8, IL-10, and TNF-α after MWA. Elevated IL-2 and IL-6 levels after ablation were positively correlated with energy output during the MWA procedure.ConclusionsMWA treatment for hepatic malignancies can alter the serum levels of several cytokines and affect the tumor status.
Ethnobotany of Bajiru (Chrysobalanus Icaco L.) In a Coastal Vegetation of Southeastern Brazil
Authors: Fonseca-Kruel Viviane Stern , Neves Maria Eduarda Rodrigues , Araujo Dorothy Sue Dunn de , Prance Ghillean T. 
Published: January 2020

Abstract
Background: Chrysobalanus icaco L. (Chrysobalanaceae) is a native but not endemic shrub species from Brazil. It is known as: abajirú, ajuru, bajirú, guajurú. There are ancient reports of edible fruits and leaves used in traditional medicine, mainly by the artisanal fishing communities of the Brazilian coast. It occurs especially in the coastal sand plains, situated between the Atlantic Ocean and the rainforest. However, in the last two decades this vegetation has been suffering strong anthropic pressures, which has led to the suppression of vegetation cover. This fact has impacted both the maintenance of plants and cultural diversity associated with it. Our study aimed to investigate current ethnobotanical knowledge about bajiru, an important species for the treatment of diabetes and recognized in the artisanal fishing communities of Southeastern Brazil to support conservation actions and sustainable management plan.Methods: This study was conducted with the artisanal fishermen community, near the Restinga de Massambaba, Brazilian costal vegetation and was supported by the signature and consent of all the fishermen involved. The collection of ethnobotanical information was performed using snowball technique, seeking artisanal fishermen who hold local knowledge, conversations and informal interviews based on rapport, semi-structured interviews and free listing. The Anthropac 4.0 software was used to calculate the highest citation frequency and highest salience among the repertoire of useful species indicated in the free listing. Complementary techniques were used: free walking with local experts for information triangulation and to collect botanical material. We used the Informant Consensus Factor (ICF) and Fidelity level (FL). Results: Interviews were conducted with 42 artisanal fishermens and bajiru was a preferred and useful species of current relevance (indicated by 32 of 42 fishermen). Its leaves are still used for diabetes treatments and with representative value of the informants' consensus in the studied sample (IFC = 0.78) and the level of fidelity of this use information (FL = 1).Conclusions: In our discussion we highlight the importance of bajiru as a potential for future studies for diabetes. Should the use of bajiru increase comercially greater plans for the conservation and possible cultivation of this specie will be needed.
Two-stage total hip arthroplasty for primary advanced septic arthritis of the hip in adults: comparison of debridement versus femoral head resection with spacer implantation
Authors: Li Zhenzhong , Wei Congcong , Li Xiangke , Yao Mengxuan , Li Huijie 
Published: January 2020

Abstract
Background To compare the outcomes of debridement and antibiotic-loaded spacer implantation in primary advanced septic arthritis (SA) of the hip in adults treated with two-stage total hip arthroplasty (THA). Methods In the first stage, 9 patients were treated with debridement and 11 patients were treated with antibiotic-loaded spacer implantation. Then, THA was conducted in all patients in the second stage. Patients were evaluated based on the recurrence of infection, Harris hip score, visual analogue scale (VAS) pain score and leg-length discrepancy. Results No cases of infection, deep vein thrombosis, death, and loosening of hip prosthesis were observed during follow-up. The mean follow-up time was 29.09 ± 10.80 months in the debridement with THA group, and 28.22 ± 14.80 months in the spacer implantation with THA group. Before the THA surgery, the mean leg-length discrepancy was 2.80 ± 2.03 cm in the debridement with THA group, and 0.50 ± 0.23 cm in the spacer implantation with THA group (P < 0.05). In the latest follow-up, The Harris hip scores of patients was 90.33 ± 4.85 in the debridement with THA group and 94.36 ± 2.34 in the spacer implantation with THA group (P < 0.05), respectively. There was no statistical significant difference in VAS pain score of the hip between the two groups (P > 0.05).Conclusions Two-stage THA using antibiotic-loaded spacer implantation is an effective method for the treatment of advanced SA of the hip in adults due to it can control infection and significantly improve functional hip.
Effect of different attributes of the mimic human lumbar spine biomechanics material structure change by finite element analysis
Authors: Da-ping Qin , Zhang Xiao-gang , Son Ming , Zhang Hua , Cao Lin-zhong , Zhao Wen-tao , Zhang Hong-wei , Zhao Xi-yun , Wang Zhi-peng , Xu Shi-wei 
Published: January 2020

Abstract
Background In this study, we compared stress changes and quantity effect relationships from 3D finite element models of normal and degenerative lumbar segments. We further defined the mechanisms causing alterations in mechanical stability the control of normal and degenerative lumbar segments using traditional Chinese medicine. Objective The characteristics of the stress change and the quantity effect relationships of the three-dimensional finite element model of normal and degenerative lumbar segments were compared. The mechanism(s) leading to changes in mechanical stability and the intervention and balance between normal and degenerative lumbar segments of the traditional Chinese medicine was analyzed. Methods A 3D-FEM of degenerative lumbar segments L4~5 of the human spine was established to simulate the physiological and pathological changes of the lumbar spine in response to flexion, extension, lateral bending and torsion. The stress changes in the normal and degenerative lumbar vertebrae were assessed through external force interventions and the response to TCM. Stress in the degenerative lumbar vertebrae changed according the external load. Stress and strain were compared in the FEM model under a range of motion states. Results Components of the human lumbar vertebrae including the cortical vertebrae, cancellous bone, endplates, fibrous rings, and facet articular processes were investigated. The elastic modulus of the nerve roots and the posterior marginal structures of the vertebral body increased with lumbar degeneration. The stress distribution in the intervertebral discs were influenced by TCM, and the space in the spinal canal enlarged so that nerve root stress decreased, vertebral body stress increased, and facet processes and pedicle stress in the posterior regions exceeded those of the anterior flexion position. The internal stress of the intervertebral disc increased in the flexion compared to the extension position, gradually increasing from top to bottom. Conclusion TCM can improve and treat lumbar disc disease through its ability to regulate the mechanical environment of degenerative lumbar vertebrae. Compared to the FEM models of the lumbar vertebrae, lumbar degenerative changes could be assessed in response to alterations in the biomechanical environment. These findings provide a scientific basis for the popularization and application of TCM to prevent and treat spinal degenerative disease.
Metabolic syndrome in haemodialysis patients: Prevalence, determinants and association to cardiovascular outcomes
Authors: Delautre Arnaud , Chantrel François , Dimitrov Yves , Klein Alexandre , Imhoff Olivier , Muller Clotilde , Schauder Nicole , Hannedouche Thierry , Krummel Thierry 
Published: January 2020

Abstract
Background In the general population, the metabolic syndrome (MetS) has been identified as predictive of major adverse cardiovascular events (MACE). Waist circumference (WC), a component of the MetS criteria, is linked to visceral obesity, which in turn is correlated with MACE. However, in haemodialysis (HD) patients, the association between MetS, WC and MACE is unclear.Methods In a cross-sectional study of 1000 HD patients, we evaluated the prevalence and characterised the clinical predictors of MetS. The relationship between MetS and its components, alone or in combination, and MACE, as defined by comorbidity among coronary diseases, peripheral arteriopathy, stroke or cardiac failure, was further studied using receiver operating characteristics (ROC) curves and logistic regression.Results A total of 753 patients were included between October 2011 and April 2013. The prevalence of MetS was 68.5%. Waist circumference (> 88 cm in women, 102 cm in men) was the best predictor of MetS (sensitivity 80.2; specificity 82.3; AUC 0.80; p < 0.05). In multivariate analysis, MetS was associated with MACE (OR: 1.85; 95CI 1.24-2.75; p < 0.01), but not WC alone. There was a stronger association between the combination of abdominal obesity, hypertriglyceridaemia and low high-density lipoprotein cholesterol with MACE after exclusion of impaired fasting glucose and hypertension.ConclusionsMetS is frequent and associated with MACE in HD patients in our region and probably in other European dialysis populations. In HD patients, a new simplified definition could be proposed, in keeping with the concept of hypertriglyceridaemic waist.
Fall Inducing Movable Platform (FIMP) for Overground Trips and Slips
Authors: Er Jie Kai , Donnelly Cyril John William , Wee Seng Kwee , Ang Wei Tech 
Published: January 2020

Abstract
The study of falls and any related fall prevention/intervention device requires the recording of true falls incidence. However, true falls are rare, random and difficult to collect. Therefore, a system that can perturb falls in an ecologically valid and repeatedly manner will greatly benefit the understanding of the neuromuscular mechanisms underpinning real-world falls events. A fall inducing movable platform (FIMP) was designed to arrest and accelerate the subject's ankle to induce trip via a brake and slip via a motor respectively. A gait phase detection algorithm was also created to allow the timely activation of the fall mechanisms to induce different recovery actions. Statistical Parametric Mapping (SPM1D) and two sample t-test were used to evaluate the transparency of the platform before it was used to induce falls. Thereafter, SPM1D and one-way repeated measure ANOVA were used assess the effectiveness of FIMP in inducing realistic falls. Walking with the FIMP's fall mechanisms attached on the ankle (SW) was found to be similar to normal walking (NW), except for a slight increase in ankle flexion during the swing phase. However, the magnitude of change would be considered negligible when compared to the changes in joint angles during the trips and slips of interest. During the FIMP induced trips, the brake activates at the terminal-swing and mid-swing gait phase to induce the lowering and skipping strategies respectively. The characteristic leg lowering and the subsequent contralateral leg swing was seen in all subjects for the lowering strategy. Likewise, for skipping strategy, all subjects skipped forward on the perturbed leg. On the other hand, slip was induced by FIMP using the motor to impart unwanted forward acceleration to the ankle with the help of friction-reducing ground sliding sheets. Joints stiffening was observed during slips, and subjects adopt the \textit{surfing} strategy after the initial slip. Results indicate that FIMP can induce reliable and ecologically valid falls repeatedly under simulated experimental conditions. The usage of SPM1D with FIMP allows the creation of the first ever quantifiable trip and slip reactive kinematics comparison. Effects of fall recovery anomalies can now be easily identified.