bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimally invasive versus open right hepatectomy: Comparative study with propensity score matching analysis
Authors: Duarte Vinicius Campos , Coelho Fabricio , Valverde Alain , Danoussou Divia , Kruger Jaime , Zuber Kevin , Fonseca Gilton , Jeismann Vagner , Herman Paulo , Lupinacci Renato 
Published: September 2020

Abstract
Background: Minimally invasive liver resections (MILRs) have been increasingly performed in recent years. However, the majority of MILRs are actually minor or limited resections of peripheral lesions. Due to the technical complexity major hepatectomies remain challenging for minimally invasive surgery. The aim of this study was to compare the short and long-term outcomes of patients undergoing minimally invasive right hepatectomies (MIRHs) with contemporary patients undergoing open right hepatectomies (ORHs). Methods: Consecutive patients submitted to anatomic right hepatectomies between January 2013 and December 2018 in two tertiary referral centers were studied. Study groups were compared on an intention-to-treat basis after propensity score matching (PSM). Overall survival (OS) analyses were performed for the entire cohort and specific etiologies subgroups. \Results: During study period 178 right hepatectomies were performed. After matching, 37 patients were included in MIRH group and 60 in ORH group. The groups were homogenous for all baseline characteristics. MIRHs had significant lower blood loss (400 ml vs. 500 ml, P=0.01), lower rate of minor complications (13.5% vs. 35%, P=0.03) and larger resection margins (10 mm vs. 5 mm, P=0.03) when compared to ORHs. Additionally, a non-significant decrease in hospital stay (ORH 9 days vs. MIRH 7 days, P=0.09) was observed. No differences regarding the use of Pringle’s maneuver, operative time, major complications or perioperative mortality were observed. OS was similar between the groups (P=0.13). Similarly, no difference in OS was found in subgroups of patients with primary liver tumors (P=0.09) and liver metastasis (P=0.80). \Conclusions: MIRHs are feasible and safe. Minimally invasive approach is associated with less blood loss, a significant reduction in minor perioperative complications, and did not negatively affect long-term outcomes.
Improvement of Near-field Tsunami Forecasting Method Using Ocean Bottom Pressure Sensor Network (S-net)
Authors: Tanioka Yuichiro 
Published: September 2020

Abstract
Since the installation of a dense cabled observation network around the Japan Trench (S-net) by the Japanese government that includes 150 sensors, several tsunami forecasting methods that use the data collected from the ocean floor sensors were developed. One of such methods is the tsunami forecasting method which assimilates the data without any information of earthquakes. The tsunami forecasting method based on the assimilation of the ocean-bottom pressure data near the source area was developed by Tanioka in 2018. However, the method is too simple to be used for an actual station distribution of S-net. To overcome its limitation, we developed an interpolation method to generate the appropriate data at the equally spaced positions for the assimilation from the data observed at sensors in S-net. The method was numerically tested for two large underthrust fault models, a giant earthquake (Mw8.8) and the Nemuro-oki earthquake (Mw8.0) models. Those fault models off Hokkaido in Japan are expected to be ruptured in the future. The weighted interpolation method, in which weights of data are inversely proportional to the square of the distance, showed good results for the tsunami forecast method with the data assimilation. Furthermore, results indicated that the method is applicable to the actual observed data at the S-net stations. The only limitation of the weighted interpolation method is that the computed tsunami wavelengths tend to be longer than the actual tsunamis wavelength.
Efficacy of closed reduction for developmental dysplasia of the hip: midterm outcomes and risk factors associated with treatment failure and avascular necrosis
Authors: Zhang Ge , Li Ming , Qu Xiangyang , Cao Yujiang , Liu Xing , Luo Cong , Zhang Yuan 
Published: September 2020

Abstract
Background: The purpose of this study was to evaluate the efficacy after closed reduction (CR) in the treatment of developmental dysplasia of the hip (DDH) and to investigate risk factors associated with CR failure and avascular necrosis (AVN) occurrence in follow-ups. Mehtods: The study retrospectively included 110 patients and 138 hips with DDH diagnosis that underwent closed reduction between February 2012 and November 2015 in our single tertiary medical institution. The failure rate of CR and the underlying risk factors were evaluated. Meanwhile, the incidence of AVN and the related risk factors among the successful CR cases were assessed.Results: The overall failure rate of DDH treated by CR in present study was 31.16% (43/138). Risk factors for the CR failure was older age at the time of CR (≥18.35 month), large medical interval before CR (≥35.35 millimeters), and severer dislocation of the affected hip (IDHI grade III and IV). The incidence of AVN was 8.33% (6/72) in the patients with successful CR at last follow-up. No significant risk factors had been established in present study that associated with the AVN occurrence.Conclusions: For the treatment of DDH with CR, patients with younger age might achieve better outcomes, early diagnosis and early treatment might be the key point in the DDH treatment.
The strategies of perioperative management in orthopedic department during the pandemic of COVID-19
Authors: Zeng Hui , Li Guoqing , Weng Jian , Xiong Ao , Xu Chang , Yang Yifei , Wang Deli 
Published: September 2020

Abstract
Background: Coronavirus disease 2019 (COVID-19) broken out and spread rapidly nationwide at the beginning of 2020, which has brought huge impacts to people and work. The current situation of prevention and control is severe and urge guidance for clinicians, especially for medical systems. In the hope of providing a reference and recommendation for the prevention and control of the COVID-19, we carried out research to improve the quality of patients care and prevention during this epidemic.Methods: All of the staff were trained rapidly to master personal protection in our department. We reviewed the patients’ discharged records who underwent surgery in our department during January 1st to March 1st in 2019 and January 1st to March 1st in 2020. The managements of the surgery patients and flow charts were described and analyzed. Post-operation outcomes of the patients including duration, complications, surgical site infection (SSI), system infection, re-operation, and mortality. Both chi-squared test and Student’s t-test were performed to determine the relationship between the two periods in term of post-operation outcomes.Results: Descriptive statistics analysis revealed that demographic of the patients between the two periods is similar. We had been benefited from the strict flow charts, smart robot and protection equipment in management of perioperative for orthopedic patients. With the help of the strict flow charts and smart equipment, post-operation outcomes of the patients revealed that the rates of the complications and re-operation had been reduced significantly (p＜0.05), while duration of operation, SSI and system infection had no significantly difference between two periods (p＞0.05). No patient and staff caught COVID-19 infection or mortality during the epidemic. Conclusions: Our study indicated that medical quality and efficiency were affected little with the help of strategies described above during the epidemic, which could be a reference tool for medical staff in routine clinical practice for admission of patients around the world. What’s more, the provided strategies, which may evolve over time, could be used as empirical guidance and reference for orthopedic peers to get through the pandemic and ensure the normal operation of the hospital.
Detection and prevalence of depression among adult type 2 diabetes mellitus patients attending non-communicable diseases clinics in Lilongwe, Malawi
Authors: Udedi Michael , Pence Brian W. , Stewart Robert C. , Muula Adamson S. 
Published: September 2020

Abstract
Background Depression is associated with chronic physical illnesses and negatively affects health outcomes. However, it often goes undiagnosed and untreated. We investigated the prevalence of depression among adult type 2 diabetes mellitus (T2DM) patients attending non-communicable diseases (NCD) clinics in Lilongwe, Malawi, and estimated the level of routine detection by NCD clinicians. This study set out to determine the prevalence of major depression and its detection among adult type 2 diabetes mellitus (T2DM) patients attending NCD clinics in Lilongwe, Malawi. Methods In a cross-sectional study design, 323 T2DM patients aged ≥18 years were screened for depression with the Patient Health Questionnare-9 (PHQ-9) followed by diagnostic assessment with the Structured Clinical Interview for DSM-IV (SCID). We analysed the association between presence of major depression and sociodemographic factors using logistic regression. Results Three quarters of the participants (76%) were females. The participants’ ages ranged from 21-79 years. Of the 323 participants, 58 (18%) met criteria for DSM-IV major depression. None of the cases of major depression had been identified by the NCD clinicians. Major depression was found not to be significantly associated with any of the sociodemographic factors.Conclusions We found that depression is common among NCD clinic attendees with T2DM in Malawi,, and poorly detected by NCD clinicians. Given the high prevalence and challenges in clinical identification, integration of depression screening with a standardized validated tool should be a high priority so as to link patients to appropriate services.
SIRT6 Promotes Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells Through Activating Notch Signaling via Antagonizing DNMT1
Authors: Jia Bo , Chen Jun , Wang Qin , Sun Xiang , Han JiuSong , Guastaldi Fernando , Xiang ShiJian , He Yan , Ye Qingsong 
Published: September 2020

Abstract
Background: Adipose-derived stem cells (ADSCs) are increasingly accepted as one of ideal seed cells for regenerative medicine for its potential to differentiate into multiple cell types, including osteogenic lineages. Sirtuin proteins 6 (SIRT6) is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase and plays important roles in a variety of biological processes, including cell differentiation.Methods: Alkaline phosphatase (ALP) activity, ALP staining, and Alizarin Red Staining was performed to explore the roles of SIRT6 in the osteogenic differentiation of ADSCs. Western blot , RT-qPCR,Luciferase reporter assay and Co-Immunoprecipitation assay were applied to confirm the relationship between of Sirt6, DNA methyltransferases (DNMTs) and NOTCHs.Results: SIRT6 leads to increased alkaline phosphatase (ALP) activity, enhanced mineralization and upregulated expression of osteogenic-related genes of human adipose-derived mesenchymal stem cells (hADSCs) in vitro and in vivo. Further mechanistic studies showed that SIRT6 regulated osteogenic differentiation of hADSCs depending on its deacetylase activity. SIRT6 selectively prevents abnormal DNA methylation of NOTCH1, NOTCH2 in hADSCs by antagonizing DNMT1. DNMT1 expression was suppressed in SIRT6 overexpression hADSCs, and knockdown partially rescued abnormal DNA methylation of NOTCH1 and NOTCH2, leading to the increased capable of osteogenic differentiation. Conculsions: SIRT6 promotes the osteogenic differentiation of hADSCs.The SIRT6 protein suppresses DNMT level via physical interaction with the DNMT1 protein, deacetylating and destabilizing DNMT1 protein,leading the activation of NOTCH1 and NOTCH2.
Stable Bagging Feature Selection on Medical Data
Authors: Alelyani Salem 
Published: September 2020

Abstract
In the medical field, distinguishing genes that are relevant to a specific disease, let's say colon cancer, is crucial to finding a cure and understanding its causes and subsequent complications. Usually, medical datasets are comprised of immensely complex dimensions with considerably small sample size. Thus, for domain experts, such as biologists, the task of identifying these genes have become a very challenging one, to say the least. Feature selection is a technique that aims to select these genes, or features in machine learning field with respect to the disease. However, learning from a medical dataset to identify relevant features suffers from the curse-of-dimensionality. Due to a large number of features with a small sample size, the selection usually returns a different subset each time a new sample is introduced into the dataset. This selection instability is intrinsically related to data variance. We assume that reducing data variance improves selection stability. In this paper, we propose an ensemble approach based on the bagging technique to improve feature selection stability in medical datasets via data variance reduction. We conducted an experiment using four microarray datasets each of which suffers from high dimensionality and relatively small sample size. On each dataset, we applied five well-known feature selection algorithms to select varying number of features. The results of the selection stability and accuracy show the improvement in terms of both the stability and the accuracy with the bagging technique.
A review of clinical profile, complications and antibiotic susceptibility pattern of extensively drug-resistant (XDR) Salmonella Typhi isolates in children in Karachi.
Authors: Shahid Saba , Mahesar Marvi , Ghouri Nida , Noreen Saba 
Published: September 2020

Abstract
Background: Enteric fever is a systemic infection, which can be caused by Salmonella enterica; Typhi and Paratyphi A. Over time, Salmonella Typhi has developed resistance to antibiotics resulting in the emergence of extensively drug-resistant (XDR) enteric fever. WHO estimated 5274 cases of XDR Enteric fever in Karachi from November 2016 to December 2019. This study aims to determine clinical course, complications and outcomes of XDR enteric fever among the pediatric population coming to Indus HospitalMethods: A retrospective chart review of pediatric patients (aged one month to 15 years) seen in Indus Hospital between July 2017 to December 2018 was conducted. A pre-designed data abstraction form was used to record detailed information about seasonality and distribution of cases, demographic details, signs and symptoms, clinical course, treatment, complications and outcomes of the cases treated for XDR Enteric feverResults: Six hundred and eighty children were included in the study. The median (IQR) age of the patients was 5 (2-8) years. More than half (n=391, 57.5%) of the patients were males. Most common clinical manifestations included fever, vomiting and diarrhea, noted in 680 (100%), 242 (35%) and 174 (25%) patients. Outcomes of 270 (39.7%) patients were recorded. Others were lost to follow up [351 (51.6%)], referred out [52 (7.6%)] or left against medical advice [7 (1%)]. 266 (39.1%) patients were cured, and four children (0.6%) expired. Seventy-eight patients (82%) and 15 patients (16.3%) got cured on Azithromycin and Meropenem alone while 157 on a combination of drugs.Conclusion: Our review indicated that children under five years of age were affected more with XDR Enteric fever. Meropenem and Azithromycin, either alone or in combination were the most effective antibiotics for treating XDR Enteric fever in children coming to Indus hospital
Size and temperature effects on dielectric breakdown of ferroelectric films
Authors: Tong Sheng 
Published: September 2020

Abstract
The paper introduces a model of dielectric breakdown strength. The model integrated thermal breakdown and defect models, representing the relationship between the electric field of ferroelectric films and dimensional parameters and operating temperature. This model is verified with experimental results of the lead lanthanum zirconate titanate (PLZT) films of various film thickness (d = 0.8 – 3 mm), electrode area (A = 0.0020 – 25 mm2) tested under a range of operating temperature (T = 300 – 400 K) with satisfying fitting results. Also learned is a relationship that the recoverable electric energy density is directly proportional to the square of breakdown electric field. This relationship is found viable in predicting the electric energy density in terms of variables of d, A, and T for the PLZT films.
Congenital myasthenic syndrome due to compound heterozygous mutations in the GFPT1 gene
Authors: Jiang Yanfang , Liu Siwen , Wang Chunyan , Yu Yan , Zhang Peng , Yu Xuefan 
Published: September 2020

Abstract
Congenital myasthenic syndrome (CMS) is a heterogeneous group of hereditary neuromuscular disorders associated with neuromuscular junction (NMJ) dysfunction. Here, we report the genetic variants and clinical follow-up of one individual suffering from CMS. The proband presented with limb weakness, and symptoms worsened after limb activities. In addition, decreases in muscle action potential were observed with repetitive nerve stimulation. Thus, myasthenia gravis was initially suspected, but the patient did not experience drooping eyelids or blurred vision. Trio whole exome sequencing was performed for the proband and his parents. We found two different heterozygous missense variants (c.331C>T; p.Arg111Cys and c.1428G>C; p.Lys476Asn) in the gene encoding glutamine-fructose-6-phosphate transaminase 1 (GFPT1) in this patient with autosomal recessive CMS, of which one was novel. The new c.1428G>C; p.Lys476Asn variant has not been previously reported, and has not been recorded in the ClinVar dataset or the gnomAD global population dataset. The phenotypes （proximal muscle weakness and fatigue while ocular and facial involvement is only minimal，limb-girdle weakness and fatigue.，beneficial and sustained response to acetylcholinesterase inhibitor treatment）of the proband were consistent with those previously reported for CMS. Our study provides important information for the diagnosis and treatment of patients with CMS.
Numerical Simulation of Coal Wall Cutting and Lump Coal Formation in a Fully Mechanized Mining Face
Authors: Yuan Yong , Wang Shengzhi , Wang Wenmiao , Zhu Cheng 
Published: September 2020

Abstract
It is difficult to accurately calculate the lump coal rate in a fully mechanized mining face. Therefore, a numerical simulation of the coal wall cutting process, which revealed the crack expansion, development, evolution in the coal body and the corresponding lump coal formation mechanism, was performed in PFC2D. Moreover, a correlation was established between the cutting force and lump coal formation, and a statistical analysis method was proposed to determine the lump coal rate. The following conclusions were drawn from the results. (1) Based on a soft ball model, a coal wall cutting model was established. By setting the roller parameters based on linear bonding and simulating the roller cutting process of the coal body, the coal wall cutting process was effectively simulated, and accurate lump coal rate statistics were provided. (2) Under the cutting stress, the coal body in the working face underwent three stages—microfracture generation, fracture expansion, and fracture penetration—to form lump coal, in which the fracture direction was orthogonal to the cutting pressure chain. Within a certain range from the roller, as the cutting depth of the roller increased, the number of new fractures in the coal body first increased and then stabilized. (3) Under the cutting stress, the fractured coal body was locally compressed, thereby forming a compact core. The formation and destruction of the compact core caused fluctuations in the cutting force. The fluctuation amplitude was positively related to the coal mass. (4) Because the simulation did not consider secondary damage in the coal, the simulated lump coal rate was larger than the actual lump coal rate in the working face; this deviation was mainly concentrated in large lump coal with a diameter greater than 300 mm.
Pyrrolnitrin Biosynthesis From Rhizospheric Serratia Spp. With Antifungal Activity and Binding Interactions of PrnF With Ligands
Authors: Pawar Shraddha P. , Chaudhari Ambalal B. 
Published: September 2020

Abstract
Pyrrolnitrin (PRN) from rhizobacteria displays a key role in biocontrol of phytopathogenic fungi in rhizospheric soil. Therefore, different rhizospheric soils were investigated for the prevalence of PRN producer in minimal salt (MS) medium containing tryptophan (0.2 M NaCl; pH 8) using three successive enrichments. Of 12% isolates, only five bacterial strains had shown PRN secretion, screened with Thin Layer Chromatography (Rf 0.8) and antifungal activity (27 mm) against phytopathogen. The phenetic and 16S rRNA sequence revealed the close affiliation of isolates (KMB, M-2, M-11, TW3, and TO2) to Stenotrophomonas rhizophila (KY800458), Enterobacter spp. (KY800455), Brevibacillus parabrevis (KY800454), Serratia marcescens (KY800456) and Serratia nemtodiphila (KY800457). Purified compound from isolates was characterised using UV, IR, HPLC, LCMS and GCMS as PRN. However, BLASTn hit of prn gene sequences from both Serratia species showed 99% similarity with NADPH dependent FMN reductase component (prnF). The homology protein model of prnF was developed from translated sequence of S. marcescens TW3 with chromate reductase of Escherichia coli K-12. Docking with FMN and NADPH was performed. The study demonstrated the possible role of prnF NADPH dependent FMN reductases in prnD for supply of reduced flavin in rhizobacterial strain of Serratia spp. which may pave a way to understand PRN production.
WITHDRAWN: A Novel Circular RNA hsa_circ_20403 Predicts Poor Prognosis and Promotes Progression in Osteosarcoma
Authors: Li Rui , Zhang Renzan , Liu Zhengpeng , Zhang Yilong 
Published: September 2020

Abstract
Objective Osteosarcoma (OS) is the most frequent bone cancer in humans. Growing evidence suggests that circular RNAs (circRNAs) exert essential roles in regulating cancer initiation and metastasis. Some research were used Illumina HiSeq to screens differentially expressed of circRNAs in OS and found that hsa_circ_20403 is highly expressed in OS. Methods In this study, we investigated the clinical application value and biological function of hsa_circ_20403 in OS. We were performed to verified the biological functions by CCK-8, flow cytometry, and transwell experiments. Results We found that the expression of circ_20403 is enhanced in both OS tissue specimens and cells. In addition, its expression is closely related to clinic opathological characteristics and prognosis. More importantly, circ_20403 was overexpressed and knocked down in OS cells. We found that circ_20403 can promote cell proliferation, migration and invasion, which can regulate the proportion of G1 and S phase cells. Conclusion Taken together, our study for the first time revealed hsa_circ_20403 as a carcinogen to promote the progression of OS. Our study suggested that hsa_circ_20403 can be used to predict the prognosis of OS and it might be a potential target for OS therapy.