bluuebunny/crossref_metadata_2025_split huggingface dataset:
eCLIPs bifurcation remodeling system for treatment of wide neck bifurcation aneurysms with extremely low dome-to-neck and aspect ratios: a multicenter experience
Authors: De Vries Joost , Boogaarts Hieronymus D , Sørensen Leif , Holtmannspoetter Markus , Benndorf Goetz , Turowski Bernd , Bohner Georg , Derakhshani Shahram , Navasa Chema , van Zwam Wim H , Söderman Michael , Rautio Riitta , Mathys Christian , Riina Howard , Marotta Thomas R 
Published: August 2020

BackgroundWide necked bifurcation aneurysms (WNBA) are among the most difficult aneurysms to treat. Very low dome-to-neck (DTN) and aspect ratios provide an even greater challenge in the management of WNBAs. We present the safety and efficacy profile for endovascular clip system (eCLIPs) device in the treatment of this subset of WNBAs with very unfavorable morphologies.MethodsIn our case series, 24 patients treated at 12 international centers were taken from a larger prospective voluntary post-marketing registry of 65 patients treated with the eCLIPs device and coiling. Those who had WNBAs at either the carotid or basilar terminus with a DTN ratio <1.6 and aspect ratio <1.2 were included. Radiologic and clinical outcomes were assessed immediately after the procedure and at the latest follow-up.ResultsThe eCLIPs device was successfully deployed in 23 cases (96%). One patient (4.2%) died due to guidewire perforation distal to the implant site. No other complications were documented. After a mean follow-up of 15.8 months (range 3–40 months), good radiologic outcomes (modified Raymond–Roy classification (MRRC) scores of 1 or 2) were documented in 20 of 21 patients (95%) with follow-up data. The lone patient with an MRRC score of 3 showed coiled compaction after incomplete neck coverage with the device.ConclusionOur series of patients with aneurysms having adverse DTN and aspect ratios demonstrated that the eCLIPs device has a safety and efficacy profile comparable with currently available devices in the treatment of WNBAs.
The professional and personal impact of the coronavirus pandemic on US neurointerventional practices: a nationwide survey
Authors: Fargen Kyle M , Leslie-Mazwi Thabele M , Klucznik Richard P , Wolfe Stacey Q , Brown Patrick , Ansari Sameer A , Dabus Guilherme , Spiotta Alejandro M , Mokin Maxim , Hassan Ameer E , Liebeskind David , Welch Babu G , Siddiqui Adnan H , Hirsch Joshua A 
Published: August 2020

BackgroundLittle is currently known about the effects of the coronavirus (COVID-19) pandemic on neurointerventional (NI) procedural volumes or its toll on physician wellness.MethodsA 37-question online survey was designed and distributed to physician members of three NI physician organizations.ResultsA total of 151 individual survey responses were obtained. Reduced mechanical thrombectomy procedures compared with pre-pandemic were observed with 32% reporting a greater than 50% reduction in thrombectomy volumes. In concert with most (76%) reporting at least a 25% reduction in non-mechanical thrombectomy urgent NI procedures and a nearly unanimous (96%) cessation of non-urgent elective cases, 68% of physicians reported dramatic reductions (>50%) in overall NI procedural volume compared with pre-pandemic. Increased door-to-puncture times were reported by 79%. COVID-19-positive infections occurred in 1% of physician respondents: an additional 8% quarantined for suspected infection. Sixty-six percent of respondents reported increased career stress, 56% increased personal life/family stress, and 35% increased career burnout. Stress was significantly increased in physicians with COVID-positive family members (P<0.05).ConclusionsThis is the first study designed to understand the effects of the COVID-19 pandemic on NI physician practices, case volumes, compensation, personal/family stresses, and work-related burnout. Future studies examining these factors following the resumption of elective cases and relaxing of social distancing measures will be necessary to better understand these phenomena.
Adult outcomes after preterm birth
Authors: Prior Emily , Modi Neena 
Published: August 2020

AbstractExtremely preterm birth reflects global disruption of the third trimester environment. Young adults born preterm have an adverse cardiovascular and metabolic health profile, together with molecular evidence of accelerated ageing and a reduced life expectancy. The underlying mechanism for these observations is unknown. This review summarises recent evidence of the lifetime effects of preterm birth and highlights the risks survivors face.
Prevalence and factors associated with advanced care directives in a motor neuron disease multidisciplinary clinic in Australia
Authors: Phua Chun Seng , Ng Aloysius , Brooks Christopher , Harrington Zinta , Vedam Hima , Huynh Thang , Seccombe Desi , Aouad Patrick , Cordato Dennis 
Published: August 2020

ABSTRACT

Objectives
Motor neuron disease (MND) is a neurodegenerative disorder leading to functional decline and death. Multidisciplinary MND clinics provide an integrated approach to management and facilitate discussion on advanced care directives (ACDs). The study objectives are to analyse (1) the prevalence of ACD in our MND clinic, (2) the relationship between ACD and patient demographics and (3) the relationship between ACD decision-making and variables such as NIV, PEG, hospital admissions and location of death.

Methods
Using clinic records, all patients who attended the MND clinic in Liverpool Hospital between November 2014 and November 2019 were analysed. Data include MND subtypes, symptom onset to time of diagnosis, time of diagnosis to death, location and reason of death. ACD prevalence, non-invasive ventilation (NIV) and percutaneous endoscopic gastrostomy (PEG) requirements were analysed.

Results
There were 78 patients; M:F=1:1. 44 (56%) patients were limb onset, 28 (36%) bulbar onset, 4 primary lateral sclerosis and 2 flail limb syndrome presentations. 27% patients completed ACDs, while 32% patients declined ACDs. Patients born in Australia or in a majority English-speaking country were more likely to complete ACDs compared to those born in a non-English-speaking country. There was no significant correlation between ACD completion and age, gender, MND subtype, symptom duration, NIV, PEG feeding, location of death.

Conclusion
One-quarter of patients completed ACDs. ACDs did not correlate with patient age, gender, MND subtype and symptom duration or decision-making regarding NIV, PEG feeding or location of death. Further studies are needed to address factors influencing patients’ decisions regarding ACDs.
Physiological and functional responses of water-cooled versus traditional radiofrequency ablation of peripheral nerves in rats
Authors: Zachariah Christa , Mayeux Jacques , Alas Guillermo , Adesina Sherry , Mistretta Olivia Christine , Ward Patricia Jill , Chen Antonia , English Arthur William , Washington Alencia V 
Published: August 2020

Background and objectives
Several clinical studies have focused on assessing the effectiveness of different radiofrequency ablation (RFA) modalities in pain management. While a direct head-to-head clinical study is needed, results from independent studies suggest that water-cooled RFA (CRFA) may result in longer lasting pain relief than traditional RFA (TRFA). The primary purpose of this study was, therefore, to investigate in a preclinical model, head-to-head differences between the two RFA technologies.

Methods
RFA was performed in a rat sciatic nerve model (n=66) in two groups: (1) TRFA or (2) CRFA. The surgeon was not blinded to the treatment; however, all the physiological endpoints were assessed in a blinded fashion which include histological, MRI, and nerve function assessment via electromyography.

Results
The energy delivered by the generator for CRFA was significantly higher compared with TRFA. Histological staining of nerves harvested immediately following CRFA exhibited extended length and multiple zones of thermal damage compared with TRFA-treated nerves. MRI scans across 4 weeks following treatment showed edematous/inflammatory zones present for longer times following CRFA. Finally, there was greater attenuation and prolonged loss of nerve function measured via electromyography in the CRFA group.

Conclusions
This study shows that CRFA has greater energy output, as well as more pronounced structural and functional changes elicited on the peripheral nerves compared with TRFA. While these preclinical data will need to be confirmed with a large clinical randomized controlled trial, we are encouraged by the direction that they may have set for those trials.
Doubly charmed multibaryon systems
Authors: Garcilazo H. , Valcarce A. 
Published: August 2020

AbstractWe study two- and three-baryon systems with two units of charm looking for possible bound states or resonances. All two-baryon interactions are consistently derived from a constituent quark model tuned in the light-flavor hadron phenomenology: spectra and interactions. The presence of the heavy quarks makes the two-body interactions simpler than in the light-flavor sector. Our results show a narrow two-body resonance with quantum numbers$$(I,J^P)=(0,0^+)$$(I,JP)=(0,0+). It is located 6.2 MeV below the$$\Sigma _c\Sigma _c$$ΣcΣcthreshold and has a width of 4.7 MeV. The foregoing two-body state contributes to generate a$$N \Sigma _c\Sigma _c$$NΣcΣcresonance with quantum numbers$$(I,J^P)=(1/2,1/2^+)$$(I,JP)=(1/2,1/2+)and a separation energy of 0.2 MeV.
Non-well-founded Proof Theory of Transitive Closure Logic
Authors: Cohen Liron , Rowe Reuben N. S. 
Published: August 2020

Supporting inductive reasoning is an essential component is any framework of use in computer science. To do so, the logical framework must extend that of first-order logic. Transitive closure logic is a known extension of first-order logic that is particularly straightforward to automate. While other extensions of first-order logic with inductive definitions are
a priori
parametrized by a set of inductive definitions, the addition of a single transitive closure operator has the advantage of uniformly capturing all finitary inductive definitions. To further improve the reasoning techniques for transitive closure logic, we here present an
infinitary
proof system for it, which is an
infinite descent
–style counterpart to the existing (explicit induction) proof system for the logic. We show that the infinitary system is complete for the standard semantics and subsumes the explicit system. Moreover, the uniformity of the transitive closure operator allows semantically meaningful complete restrictions to be defined using simple syntactic criteria. Consequently, the restriction to regular infinitary (i.e.,
cyclic
) proofs provides the basis for an effective system for automating inductive reasoning.
Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity In Vitro and In Vivo
Authors: Ohol Yamini M. , Sun Michael T. , Cutler Gene , Leger Paul R. , Hu Dennis X. , Biannic Berenger , Rana Payal , Cho Cynthia , Jacobson Scott , Wong Steve T. , Sanchez Jerick , Shah Niket , Pookot Deepa , Abraham Betty , Young Kyle , Suthram Silpa , Marshall Lisa A. , Bradford Delia , Kozon Nathan , Han Xinping , Okano Akinori , Maung Jack , Colas Christophe , Schwarz Jacob , Wustrow David , Brockstedt Dirk G. , Kassner Paul D. 
Published: August 2020

Abstract
The deubiquitinase USP7 regulates the levels of multiple proteins with roles in cancer progression and immune response. Thus, USP7 inhibition may decrease oncogene function, increase tumor suppressor function, and sensitize tumors to DNA-damaging agents. We have discovered a novel chemical series that potently and selectively inhibits USP7 in biochemical and cellular assays. Our inhibitors reduce the viability of multiple TP53 wild-type cell lines, including several hematologic cancer and MYCN-amplified neuroblastoma cell lines, as well as a subset of TP53-mutant cell lines in vitro. Our work suggests that USP7 inhibitors upregulate transcription of genes normally silenced by the epigenetic repressor complex, polycomb repressive complex 2 (PRC2), and potentiate the activity of PIM and PI3K inhibitors as well as DNA-damaging agents. Furthermore, oral administration of USP7 inhibitors inhibits MM.1S (multiple myeloma; TP53 wild type) and H526 (small cell lung cancer; TP53 mutant) tumor growth in vivo. Our work confirms that USP7 is a promising, pharmacologically tractable target for the treatment of cancer.
Abstract A021: Multilevel approaches to breast cancer disparities in the United States: An integrative review
Authors: Hohl Sarah D. , Thompson Beti , Molina Yamile , Paskett Electra D. 
Published: August 2020

Abstract
Background: Breast cancer is the most common cancer diagnosed among women and the leading cause of cancer death among women worldwide. Since 1990, breast cancer incidence has remained stable and mortality has decreased 2% per year in the U.S. However, ethnic minority and socioeconomically disadvantaged women have not experienced these gains in breast cancer outcomes. Understanding shared factors at different levels across disparities may be helpful for improving the well-being of multiple marginalized populations in the U.S. as well as potentially in other countries.
Methods: We conducted an integrative, qualitative review of the literature from 2008-2018 to describe the burden of breast cancer and multilevel interventions to address disparities among three unique, underserved groups in the U.S. We searched Google Scholar and PubMed as well as county, state, and national public health databases and summarized the relevant literature.
Results: African Americans in Chicago, non-Latina White women in Appalachia, and Latinas in the Yakima Valley of Washington State represent three subgroups in the U.S. who suffer disproportionately from breast cancer, including late-stage diagnoses, aggressive subtypes, and poor survival. These characteristics are influenced by biologic, individual, social, and societal factors including gene expression, fear and fatalism, poverty and neighborhood, and access to care. Multilevel interventions across the three geographic areas have included patient navigation and community health workers to bolster education and enhance health care access, support groups, and political advocacy.
Conclusion: African Americans in Chicago, non-Latina White women in Appalachia, and Latinas in the Yakima Valley of Washington State share disproportionate exposure to a myriad of social determinants of health that contribute to lower rates of breast cancer detection and treatment as well as poorer survival. Concerted efforts that address these factors are needed to ensure that all women have access to equitable screening, detection, treatment, and survivorship resources.
Citation Format: Sarah D. Hohl, Beti Thompson, Yamile Molina, Electra D. Paskett. Multilevel approaches to breast cancer disparities in the United States: An integrative review [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr A021.
Abstract B037: The role of HIV status in health-related quality of life in gay and bisexual prostate cancer survivors: Findings from the Restore study
Authors: Polter Elizabeth J. , Wheldon Christopher W. , Kohli Nidhi , Rosser B. R. S. 
Published: August 2020

Abstract
Objective: Prostate cancer is the most common invasive cancer in gay and bisexual men. Despite the unique sexual and urinary concerns of this group, nearly all studies of prostate cancer rehabilitation post-treatment have focused on heterosexual men. Older gay and bisexual men, the generation most likely to experience prostate cancer, also have high prevalence of human immunodeficiency virus (HIV), which is associated with lower quality of life. Research has indicated that people with HIV may experience health disparities in cancer treatment, but to our knowledge, this is the first quantitative study of the association between HIV status and health-related quality of life (HRQOL) in gay and bisexual men with prostate cancer.
Methods: Data from the Restore study, a cross-sectional online survey of gay and bisexual men treated for prostate cancer and residing in the United States or Canada, were used to examine this association. The Expanded Prostate Cancer Index Composite (EPIC) was used to assess function and bother in four domains: urinary, sexual, bowel, and hormone. Overall physical and mental HRQOL was assessed utilizing the SF-12 Health Survey. Multivariate analysis of variance (MANOVA) was used to evaluate the association between HIV status and HRQOL scores. Models were adjusted for age, race, treatment (prostatectomy, radiation, or advanced treatment), relationship status (partnered/married versus single/dating/widowed/divorced), preferred role in sex, and number of comorbidities.
Results: Of 193 participants, 24 (12.4%) reported an HIV diagnosis, including 3 diagnosed after their prostate cancer treatment. The cohort was 89 percent white, with mean age 63.4 years. After adjustment for demographic and treatment characteristics, HIV-positive status was associated with lower scores on the EPIC urinary (RD: -10.8, 95% CI: -19.5 to -2.2) and sexual (RD: -10.3, 95% CI: -20.2 to -0.4) domains. Although there were no statistically significant associations found in the other domains, HIV-positive participants reported lower outcomes in all domains except the SF-12 mental domain (RD: 0.3, 95% CI: -5.0 to 5.6).
Conclusion: Our findings, though imprecise, provide evidence that HIV status may be associated with poorer HRQOL in gay and bisexual prostate cancer survivors.
Citation Format: Elizabeth J. Polter, Christopher W. Wheldon, Nidhi Kohli, B. R. S. Rosser. The role of HIV status in health-related quality of life in gay and bisexual prostate cancer survivors: Findings from the Restore study [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr B037.
Abstract B048: Understanding the molecular basis of ER (+) breast cancer among racial groups: Metabolic and proteomic profiling
Authors: Santaliz-Casiano Ashlie M. , Madak-Erdogan Zeynep 
Published: August 2020

Abstract
Breast cancer (BC) mortality for African-American (AA) women in the U.S. is 40% higher than that for non-Hispanic white (Caucasian) women, even though these racial groups have the same incidence rate. The racial disparities might be attributed to socioeconomic status differences; however, they might as well be due to genetic and other nongenetic factors. In our preliminary studies, we found that several angiogenic factors were differentially increased in serum from African-American women with breast cancer risk. We hypothesize that these factors are drivers of inherent biologic differences of increased angiogenesis and tumor aggressiveness and that the serum composition will affect the production of angiogenic factors from breast cancer cells. We expect that we will identify a common and different set of molecules that might impact angiogenic pathways in cell lines derived from African-American and Caucasian women through metabolic and proteomic profiling. These findings will enable us to understand the molecular mechanism behind breast cancer disparities, indicating that serum composition and particular metabolites or proteins specific to African American are affecting breast cancer, therefore giving us a better understanding in order to bridge the racial disparities gap between breast cancer patients and their outcomes.
Citation Format: Ashlie M. Santaliz-Casiano, Zeynep Madak-Erdogan. Understanding the molecular basis of ER (+) breast cancer among racial groups: Metabolic and proteomic profiling [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr B048.
Abstract B053: Expression of alternative mRNA splicing variant MBD2_v2 promotes triple-negative breast cancer tumor initiation and is associated with body mass index
Authors: Teslow Emily A. , Mitrea Cristina , Bao Bin , Mohammad Ramzi M. , Polin Lisa A. , Dyson Greg , Purrington Kristen S. , Bollig-Fischer Aliccia 
Published: August 2020

Abstract
According to epidemiologic research, obesity is a risk factor for triple-negative breast cancer (TNBC). The underlying molecular biology remains unknown. We reasoned that obesity-induced chronic inflammation, reactive oxygen species (ROS) being central, serves as the general link to TNBC. We are the first to report that expression of the epigenetic reader methyl-CpG-binding domain protein 2 mRNA variant MBD2_v2 in TNBC cell cultures depends on ROS and is necessary to maintain and promote expansion of cancer stem cell-like cells (CSCs). The relevance of CSCs is that they are a subpopulation of cancer cells recognized as the source of malignant tumor initiation, and they give rise to drug resistance and metastatic recurrence. We also previously reported evidence that MBD2_v2 expression underlies TNBC resistance to EGFR inhibitor drugs. Now, having used a diet-induced obesity (DIO) mouse model that mimics human obesity, we report that MBD2_v2 and serine/arginine-rich mRNA splicing factor 2 (SRSF2) levels were increased in tumors that formed more frequently in DIO mice relative to lean controls. To more directly test if increased MBD2_v2 drives increased tumor initiation capacity, we stably modified MBD2_v2 or SRSF2 expression in TNBC cells prior to inoculation. MBD2_v2 overexpression increased tumor initiation while SRSF2 knockdown, resulting in decreased MBD2_v2 expression, attenuated tumor formation. In addition, our analysis of TNBC patient tumors revealed a significant positive association for MBD2_v2 expression and body mass index (BMI). African American (AA) women are 1.7 times more often obese relative to European American women, and a TNBC driver mechanism fueled by obesity-coupled inflammation could underlie the higher incidence of TNBC among AA women.
Citation Format: Emily A. Teslow, Cristina Mitrea, Bin Bao, Ramzi M. Mohammad, Lisa A. Polin, Greg Dyson, Kristen S. Purrington, Aliccia Bollig-Fischer. Expression of alternative mRNA splicing variant MBD2_v2 promotes triple-negative breast cancer tumor initiation and is associated with body mass index [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr B053.