bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a Nowcasting Capability for X‐Class Solar Flares Using VLF Radiowave Propagation Changes.
Authors: George Harriet E. , Rodger Craig J. , Clilverd Mark A. , Cresswell‐Moorcock Kathy , Brundell James B. , Thomson Neil R. 
Published: December 2019

AbstractA technique for analyzing very low frequency (VLF) radiowave signals is investigated in order to achieve rapid, real‐time detection of large solar flares, through the monitoring of changes in VLF radio signal propagation conditions. The reliability of the use of VLF phase and amplitude perturbations to determine the X‐ray fluxes involved during 10 large solar flare events (>X1) is examined. Linear regression analysis of signals from the NPM transmitter in Hawaii, received at Arrival Heights, Scott Base, Antarctica, over the years 2011–2015 shows that VLF phase perturbations during large solar flares have a 1.5–3 times lower mean square error when modeling the long wavelength X‐ray fluxes than the equivalent short wavelength fluxes. The use of VLF amplitude observations to determine long or short wavelength X‐ray flux levels have a 4–10 times higher mean square error than when using VLF phase. Normalized linear regression analysis identifies VLF phase as the most important parameter in the regression, followed by solar zenith angle at the midpoint of the propagation path, then the initial solar X‐ray flux level (from 5 min before the impact of the solar flare), with F10.7 cm flux from the day beforehand providing the least important contribution. Transmitter phase measurements are more difficult to undertake than amplitude. However, networks of VLF receivers already exist which include the high quality phase capability required for such a nowcasting product. Such narrowband VLF data can be a redundant source of flare monitoring if satellite data is not available.
The Value of Subseasonal Hydrometeorological Forecasts to Hydropower Operations: How Much Does Preprocessing Matter?
Authors: Anghileri D. , Monhart S. , Zhou C. , Bogner K. , Castelletti A. , Burlando P. , Zappa M. 
Published: December 2019

AbstractThe quality of the forecasts, that is, the accuracy in predicting the observed streamflow, affects the decisions that can be taken thus determining the success or failure of hydropower operations, that is, the so‐called forecast value. Although preprocessing techniques can be employed to improve forecast quality, the corresponding improvement in forecast value to hydropower is not straightforward to anticipate because of the complex relationship between quality and value, which depends on the hydrometeorological regime and water system features. The objective of this paper is to demonstrate the value to hydropower reservoir operations of preprocessed (i.e., bias corrected and downscaled) subseasonal forecasts and to compare the forecast quality and value across and within seasons. We use the forecast ensembles provided by the European Center for Medium‐Range Weather Forecasts (ECMWF). We assess forecast quality in terms of bias, Continuous Ranked Probability Score (CRPS), and Continuous Ranked Probability Skill Score (CRPSS), and forecast value in terms of mean revenue and avoided unproductive spill. We consider daily subseasonal hydrometeorological forecasts covering lead times up to 1 month and a quantile mapping technique to preprocess the hydrometeorological forecasts. Forecasts are then used in a rolling horizon set up to optimize hydropower operations of the Verzasca hydropower system in the Alps (CH). Results show that preprocessing is essential to improve both forecast quality and value. Although hydropower reservoir operations benefit from considering forecasts all the yearlong, the relationship between forecast quality and value is complex and strongly depends on the metrics used to assess forecast quality and value and on the season.
The MS-lincRNA landscape reveals a novel lincRNA BCLIN25 that contributes to tumorigenesis by upregulating ERBB2 expression via epigenetic modification and RNA–RNA interactions in breast cancer
Authors: Xu Shouping , Liu Hongbo , Wan Lin , Zhang Weijia , Wang Qin , Zhang Shumei , Shang Shipeng , Zhang Yan , Pang Da 
Published: December 2019

AbstractThe landscape of molecular subtype-specific long intergenic noncoding RNAs (MS-lincRNAs) in breast cancer has not been elucidated. No study has investigated the biological function of BCLIN25, serving as a novel HER2 subtype-specific lincRNA, in human disease, especially in malignancy. Moreover, the mechanism of BCLIN25 in the regulation of ERBB2 expression remains unknown. Our present study aimed to investigate the role and underlying mechanism of BCLIN25 in the regulation of ERBB2 expression. The transcriptional landscape across five subtypes of breast cancer was investigated using RNA sequencing. Integrative transcriptomic analysis was performed to identify the landscape of novel lincRNAs. Next, WEKA was used to identify lincRNA-based subtype classification and MS-lincRNAs for breast cancer. The MS-lincRNAs were validated in 250 breast cancer samples in our cohort and datasets from The Cancer Genome Atlas and Gene Expression Omnibus. Furthermore, BCLIN25 was selected, and its role in tumorigenesis was examined in vitro and in vivo. Finally, the mechanism by which BCLIN25 regulates ERBB2 expression was investigated in detail. A total of 715 novel lincRNAs were differentially expressed across five breast cancer subtypes. Next, lincRNA-based subtype classifications and MS-lincRNAs were identified and validated using our breast cancer samples and public datasets. BCLIN25 was found to contribute to tumorigenesis in vitro and in vivo. Mechanistically, BCLIN25 was shown to increase the expression of ERBB2 by enhancing promoter CpG methylation of miR-125b, leading to miR-125b downregulation. In turn, ERBB2 mRNA degradation was found to be abolished due to decreased binding of miR-125b to the 3’-untranslated region (UTR) of ERBB2. These findings reveal the role of novel lincRNAs in breast cancer and provide a comprehensive landscape of breast cancer MS-lincRNAs, which may complement the current molecular classification system in breast cancer.
Imagery of internal structure and destabilization features of active volcano by 3D high resolution airborne electromagnetism
Authors: Dumont Marc , Peltier Aline , Roblin Else , Reninger Pierre-Alexandre. , Barde-Cabusson Stéphanie , Finizola Anthony , Ferrazzini Valérie 
Published: December 2019

AbstractPresent-day volcano imaging and monitoring relies primarily on ground surface and satellite remote sensing observations. The overall understanding of the volcanic edifice and its dynamics is thus limited by surface investigation, spatial resolution and penetration depth of the ground methods, but also by human and material resources, and harsh environments. Here, we show for the first time that an airborne electromagnetic survey provides a 3D global resistivity model of an active volcano. The high-resolution survey acquired at the Piton de la Fournaise volcano on La Réunion Island, Indian Ocean, shows unprecedented details of the internal structure of the edifice, highlighting the upwelling hydrothermal system below the craters, magma intrusion pathways and inherited faults. Together with surface monitoring, such airborne imagery have a high potential to better characterize volcano internal structure and magmatic processes, and therefore to better anticipate catastrophic events such as phreato-magmatic eruptions or volcano destabilizations.
Multicaloric effect in a multiferroic composite of Gd5(Si,Ge)4 microparticles embedded into a ferroelectric PVDF matrix
Authors: Andrade V. M. , Amirov A. , Yusupov D. , Pimentel B. , Barroca N. , Pires A. L. , Belo J. H. , Pereira A. M. , Valente M. A. , Araújo J. P. , Reis M. S. 
Published: December 2019

AbstractThe coupling between electric, magnetic and elastic features in multiferroic materials is an emerging field in materials science, with important applications on alternative solid-state cooling technologies, energy harvesting and sensors/actuators. In this direction, we developed a thorough investigation of a multiferroic composite, comprising magnetocaloric/magnetostrictive Gd$${}_{5}$$

5

Si$${}_{2.4}$$

2.4

Ge$${}_{1.6}$$

1.6

microparticles blended into a piezo- and pyroelectric poly(vinylidene) fluoride (PVDF) matrix. Using a simple solvent casting technique, the formation and stabilization of PVDF electroactive phases are improved when the filler content increases from 2 to 12 weight fraction (wt.%). This effect greatly contributes to the magnetoelectric (ME) coupling, with the ME coefficient $${\alpha }_{ME}$$

α

M
E

increasing from 0.3 V/cm.Oe to 2.2 V/cm.Oe, by increasing the amount of magnetic material. In addition, magnetic measurements revealed that the ME-coupling has influenced the magnetocaloric effect via a contribution from the electroactive polymer and hence leading to a multicaloric effect. These results contribute to the development of multifunctional systems for novel technologies.
Investigating Ammonium By-product Removal for Ureolytic Bio-cementation Using Meter-scale Experiments
Authors: Lee Minyong , Gomez Michael G. , San Pablo Alexandra C. M. , Kolbus Colin M. , Graddy Charles M. R. , DeJong Jason T. , Nelson Douglas C. 
Published: December 2019

AbstractMicrobially Induced Calcite Precipitation (MICP), or bio-cementation, is a promising bio-mediated technology that can improve the engineering properties of soils through the precipitation of calcium carbonate. Despite significant advances in the technology, concerns regarding the fate of produced NH4+ by-products have remained largely unaddressed. In this study, five 3.7-meter long soil columns each containing one of three different soils were improved using ureolytic bio-cementation, and post-treatment NH4+ by-product removal was investigated during the application of 525 L of a high pH and high ionic strength rinse solution. During rinsing, reductions in aqueous NH4+ were observed in all columns from initial concentrations between ≈100 mM to 500 mM to final values between ≈0.3 mM and 20 mM with higher NH4+ concentrations observed at distances furthest from the injection well. In addition, soil Vs measurements completed during rinse injections suggested that no significant changes in cementation integrity occurred during NH4+ removal. After rinsing and a 12 hour stop flow period, all column solutions achieved cumulative NH4+ removals exceeding 97.9%. Soil samples collected following rinsing, however, contained significant sorbed NH4+ masses that appeared to have a near linear relationship with surrounding aqueous NH4+ concentrations. While these results suggest that NH4+ can be successfully removed from bio-cemented soils, acceptable limits for NH4+ aqueous concentrations and sorbed NH4+ masses will likely be governed by site-specific requirements and may require further investigation and refinement of the developed techniques.
Physiologic intestinal 18F-FDG uptake is associated with alteration of gut microbiota and proinflammatory cytokine levels in breast cancer
Authors: Yoon Hai-Jeon , Kim Han-Na , Bang Ji-In , Lim Woosung , Moon Byung In , Paik Nam Sun , Kim Bom Sahn , Kim Hyung-Lae 
Published: December 2019

AbstractThe clinical significance of physiologic Fluorine-18-fluorodeoxyglucose (18F-FDG) intestinal uptake (IU) based on the predicted link with gut microbiota dysbiosis and inflammatory cytokine production was investigated in a cohort of breast cancer patients. A total of 114 patients were visually classified into the lower or higher IU group. The maximum and mean standardized uptake values of total bowel (TB SUVmax and TB SUVmean) were measured. The gut microbial abundance of the Citrobacter genus of the Enterobacteriaceae family showed a significant positive correlation with TB SUVmax and TB SUVmean (q = 0.021 and q = 0.010). The unclassified Ruminococcaceae showed a significant negative correlation with TB SUVmax (q = 0.010). The level of tumor necrosis factor alpha (TNF-α) was significantly increased in the high IU group (p = 0.017). The TNF-α levels showed a significant positive correlation with TB SUVmax (rho = 0.220 and p = 0.018) and TB SUVmean (rho = 0.250 and p = 0.007). Therefore, our findings suggest that the physiologic intestinal uptake may reflect subclinical inflammation and differences in the composition of the gut microbiome in breast cancer patients.
Early life cognitive development trajectories and intelligence quotient in middle childhood and early adolescence in rural western China
Authors: Zhu Zhonghai , Chang Suying , Cheng Yue , Qi Qi , Li Shaoru , Elhoumed Mohamed , Yan Hong , Dibley Michael J. , Fawzi Wafaie W. , Zeng Lingxia , Sudfeld Christopher R. 
Published: December 2019

AbstractThe relationship of cognitive developmental trajectories during the dynamic first years with later life development outcomes remains unclear in low- and middle-income countries. 1388 Children born to women who participated in a randomized trial of antenatal micronutrient supplementation in rural China were prospectively followed. Cognitive development was assessed six times between 3 and 30 months of age using Bayley Scales of Infant Development, and then in mid-childhood (7–9 years) and early adolescence (10–12 years) using Wechsler Intelligence Scale for Children. We identified four distinct infant cognitive development trajectory subgroups using group-based trajectory modeling: (i) consistently above average, (ii) consistently average, (iii) started below average and then improved, and (iv) started below average and then declined. LBW infants (<2500 g) were 10.60 times (95% CI 3.57, 31.49) more likely to be in the trajectory group that started below average and then declined, while each grade increase in maternal education decreased the risk of being in this group by 73% (95% CI 54%, 84%). Infants who performed consistently above average had 8.02 (95% CI 1.46, 14.59) points higher IQ in adolescence versus the declining trajectory group. These findings suggest that interventions to improve early child development trajectories may produce long-term human capital benefits.
Cyanide produced with ethylene by ACS and its incomplete detoxification by β-CAS in mango inflorescence leads to malformation
Authors: Ansari Mohammad Wahid , Kaushik Shail , Bains Gurdeep , Tula Suresh , Joshi Bhavana , Rani Varsha , Wattal Ratnum Kaul , Rakwal Randeep , Shukla Alok , Pant Ramesh Chandra , Tuteja Renu , Tuteja Narendra 
Published: December 2019

AbstractMalformation of mango inflorescences (MMI) disease causes severe economic losses worldwide. Present research investigates the underlying causes of MMI. Results revealed significantly higher levels of cyanide, a by-product of ethylene biosynthesis, in malformed inflorescences (MI) of mango cultivars. There was a significant rise inACStranscripts, ACS enzyme activity and cyanide and ethylene levels in MI as compared to healthy inflorescences (HI). Significant differences in levels of methionine, phosphate, S-adenosyl-L-methionine, S-adenosyl-L-homocysteine, ascorbate and glutathione, and activities of dehydroascorbate reductase and glutathione reductase were seen in MI over HI. Further, a lower expression of β-cyanoalanine synthase (β-CAS) transcript was associated with decreased cellular β-CAS activity in MI, indicating accumulation of unmetabolized cyanide. TEM studies showed increased gum-resinosis and necrotic cell organelles, which might be attributed to unmetabolized cyanide. In field trials, increased malformed-necrotic-inflorescence (MNI) by spraying ethrel and decreased MNI by treating with ethylene inhibitors (silver and cobalt ions) further confirmed the involvement of cyanide in MMI. Implying a role for cyanide in MMI at the physiological and molecular level, this study will contribute to better understanding of the etiology of mango inflorescence malformation, and also help manipulate mango varieties genetically for resistance to malformation.
MSC Transplantation Improves Lacrimal Gland Regeneration after Surgically Induced Dry Eye Disease in Mice
Authors: Dietrich Jana , Ott Lolita , Roth Mathias , Witt Joana , Geerling Gerd , Mertsch Sonja , Schrader Stefan 
Published: December 2019

AbstractDry eye disease (DED) is a multifactorial disease characterized by a disrupted tear film homeostasis and inflammation leading to visual impairments and pain in patients. Aqueous-deficient dry eye (ADDE) causes the most severe progressions and depends mainly on the loss of functional lacrimal gland (LG) tissue. Despite a high prevalence, therapies remain palliative. Therefore, it is of great interest to develop new approaches to curatively treat ADDE. Mesenchymal stem/stromal cells (MSC) have been shown to induce tissue regeneration and cease inflammation. Moreover, an increasing amount of MSC was found in the regenerating LG of mice. Therefore, this study investigated the therapeutic effect of MSC transplantation on damaged LGs using duct ligation induced ADDE in mice. Due to the transplantation of sex-mismatched and eGFP-expressing MSC, MSC could be identified and detected until day 21. MSC transplantation significantly improved LG regeneration, as the amount of vital acinar structures was significantly increased above the intrinsic regeneration capacity of control. Additionally, MSC transplantation modulated the immune reaction as macrophage infiltration was delayed and TNFα expression decreased, accompanied by an increased IL-6 expression. Thus, the application of MSC appears to be a promising therapeutic approach to induce LG regeneration in patients suffering from severe DED/ADDE.
Microfluidic synthesis of methyl jasmonate-loaded PLGA nanocarriers as a new strategy to improve natural defenses in Vitis vinifera
Authors: Chronopoulou Laura , Donati Livia , Bramosanti Marco , Rosciani Roberta , Palocci Cleofe , Pasqua Gabriella , Valletta Alessio 
Published: December 2019

AbstractThe objective of the present work was to synthesize biopolymeric nanoparticles (NPs) entrapping the resistance-inductor methyl jasmonate (MeJA) to be employed as a novel and alternative strategy in integrated pest management. NPs were prepared by using a continuous flow microfluidic reactor that allows to precisely control some features that are crucial for applications such as size, polydispersion, morphology and reproducibility. Poly(lactic-co-glycolic acid) (PLGA), a biopolymer largely studied for its use in biological applications, was chosen for the production of NPs entrapping MeJA, a biotic endogenous elicitor able to trigger plant’s defense responses. The effect of different fluid-dynamic conditions, PLGA molecular weight and concentration on NP properties (dimensions, polydispersion, morphology, stability) was evaluated. DLS and SEM were employed to characterize the obtained NPs. MeJA-loaded PLGA NPs ranging from 40 to 70 nm were administered to Vitis vinifera cell cultures, in order to evaluate the biological response in terms of stilbene biosynthesis. HPLC investigations showed a faster response when the elicitor was administered by PLGA NPs in comparison with free MeJA. This result demonstrates that the encapsulation in PLGA NPs significantly promotes MeJA cell uptake and the activation of MeJA-induced responses.
Chlamydia trachomatis serovars in urogenital and ocular samples collected 2014–2017 from Austrian patients
Authors: Lesiak-Markowicz Iwona , Schötta Anna-Margarita , Stockinger Hannes , Stanek Gerold , Markowicz Mateusz 
Published: December 2019

AbstractInfection of humans with Chlamydia trachomatis, a bacterial pathogen with a unique intracellular replication cycle, may cause a variety of clinical manifestations. These are linked to various serovars of the pathogen; trachoma to serovars A-C, oculogenital infections to serovars D-K, and lymphogranuloma venereum to serovars L1-L3. Nineteen serovars are known as human pathogens. The aim of the study was to determine the serovars of 401 C. trachomatis DNA positive extracts from original clinical specimens of patients in Austria including cervical and urethral swabs, urine, genital secretions and conjunctival swabs - collected from 2014 to 2017. Sequence analysis of the omp1 gene, encoding major outer-membrane protein was performed on each sample. In 50.1% of samples serovar E was identified and serovars F, D/Da and G/Ga were found in 16.2%, 9.7% and 9.0%, respectively. Remaining serovars were J (6.0%), K (4.7%), H (2.7%), B/Ba (1.0%), and I/Ia (0.5%). In 19 patients follow up samples could be tested. The majority of C. trachomatis serovars were associated with urogenital tract infections (D-K), however, one of them – serovar B/Ba - is linked to both, ocular and genital tract infection.
A novel application of hematite precipitation for high effective separation of Fe from Nd-Fe-B scrap
Authors: Lin Xue , Qu Zhan , Chen Yu , Jin Ruinan , Su Ting , Yu Yang , Zhu Suiyi , Huo Mingxin , Peng Juwei , Wang Zhaofeng 
Published: December 2019

AbstractRare earths, e.g. neodymium (Nd), praseodymium (Pr) and dysprosium (Dy), are abundant in the rare earth sintered magnet scrap (Nd-Fe-B scrap), but their recycling is tedious and costly due to the high content of impurity Fe. Herein, a novel approach was developed to effectively recycle rare earths from the scrap via an integrated acid dissolution and hematite precipitation method. The scrap contained 63.4% Fe, 21.6% Nd, 8.1% Pr and 3.9% Dy. It was dissolved in nitric, hydrochloric and sulfuric acids, separately. Nearly all impurity Fe in the scrap was converted to Fe3+ in nitric acid but was converted to Fe2+ in hydrochloric and sulfuric acids. After hydrothermal treatment, the rare earths in the three acids were almost unchanged. From nitric acid, 77.6% of total Fe was removed, but total Fe was not from the hydrochloric and sulfuric acids. By adding glucose, the removal of total Fe was further increased to 99.7% in nitric acid, and 97% of rare earths remained. The major mechanism underlying total Fe removal in nitric acid was the hydrolysis of Fe3+ into hematite, which was promoted by the consumption of nitrate during glucose oxidation. This method effectively recycled rare metals from the waste Nd-Fe-B scrap and showed great potential for industrial application.
Labour sharing promotes coexistence in atrazine degrading bacterial communities
Authors: Billet Loren , Devers Marion , Rouard Nadine , Martin-Laurent Fabrice , Spor Aymé 
Published: December 2019

AbstractMicrobial communities are pivotal in the biodegradation of xenobiotics including pesticides. In the case of atrazine, multiple studies have shown that its degradation involved a consortia rather than a single species, but little is known about how interdependency between the species composing the consortium is set up. The Black Queen Hypothesis (BQH) formalized theoretically the conditions leading to the evolution of dependency between species: members of the community called ‘helpers’ provide publicly common goods obtained from the costly degradation of a compound, while others called ‘beneficiaries’ take advantage of the public goods, but lose access to the primary resource through adaptive degrading gene loss. Here, we test whether liquid media supplemented with the herbicide atrazine could support coexistence of bacterial species through BQH mechanisms. We observed the establishment of dependencies between species through atrazine degrading gene loss. Labour sharing between members of the consortium led to coexistence of multiple species on a single resource and improved atrazine degradation potential. Until now, pesticide degradation has not been approached from an evolutionary perspective under the BQH framework. We provide here an evolutionary explanation that might invite researchers to consider microbial consortia, rather than single isolated species, as an optimal strategy for isolation of xenobiotics degraders.