bluuebunny/crossref_metadata_2025_split huggingface dataset:
First-year college students’ weight change is influenced by their randomly assigned roommates’ BMI
Authors: van Woerden Irene , Hruschka Daniel , Brewis Alexandra , Schaefer David R. , Bruening Meg 
Published: November 2020

Background
There is ongoing debate about whether friends’ greater similarity in Body Mass Index (BMI) than non-friends is due to friend selection, shared environments, or peer influence.

Methods
First-year college students (n = 104) from a southwestern U.S. university were randomly assigned roommates during the university’s housing process, effectively removing friend selection effects. Participant BMI was measured up to four times (T1-T4) across 2015–2016. The influence of roommate baseline BMI (T1) on change in participant BMI over time (T2-T4) was analyzed using a linear mixed effects model adjusted for individual socio-demographics, linear time trends, baseline BMI, and physical clustering of students. A sensitivity analysis examining floormates was also conducted.

Results
Consistent with roommate influence, participants randomized to roommates with a higher BMI gained more weight between times T2 and T4 (β = 0.06; 95% CI = 0.02, 0.10). No shared environment effects (shared campus or floor) were found.

Conclusions
Randomly assigned roommates influenced each other's weight trajectories. This clarifies that BMI convergence can occur outside of friend selection or shared environments mechanisms.
Acacetin suppresses the electrocardiographic and arrhythmic manifestations of the J wave syndromes
Authors: Di Diego José M. , Patocskai Bence , Barajas-Martinez Hector , Borbáth Virág , Ackerman Michael J. , Burashnikov Alexander , Clatot Jérôme , Li Gui-Rong , Robinson Victoria M. , Hu Dan , Antzelevitch Charles 
Published: November 2020

BackgroundJ wave syndromes (JWS), including Brugada (BrS) and early repolarization syndromes (ERS), are associated with increased risk for life-threatening ventricular arrhythmias. Pharmacologic approaches to therapy are currently very limited. Here, we evaluate the effects of the natural flavone acacetin.MethodsThe effects of acacetin on action potential (AP) morphology and transient outward current (Ito) were first studied in isolated canine RV epicardial myocytes using whole-cell patch clamp techniques. Acacetin’s effects on transmembrane APs, unipolar electrograms and transmural ECGs were then studied in isolated coronary-perfused canine RV and LV wedge preparations as well as in whole-heart, Langendorff-perfused preparations from which we recorded a 12 lead ECG and unipolar electrograms. Using floating glass microelectrodes we also recorded transmembrane APs from the RVOT of the whole-heart model. The Itoagonist NS5806, sodium channel blocker ajmaline, calcium channel blocker verapamil or hypothermia (32°C) were used to pharmacologically mimic the genetic defects and conditions associated with JWS, thus eliciting prominent J waves and provoking VT/VF.ResultsAcacetin (5–10 μM) reduced Itodensity, AP notch and J wave area and totally suppressed the electrocardiographic and arrhythmic manifestation of both BrS and ERS, regardless of the experimental model used. In wedge and whole-heart models of JWS, increasing Itowith NS5806, decreasing INaor ICa(with ajmaline or verapamil) or hypothermia all resulted in accentuation of epicardial AP notch and ECG J waves, resulting in characteristic BrS and ERS phenotypes. Phase 2-reentrant extrasystoles originating from the RVOT triggered VT/VF. The J waves in leads V1 and V2 were never associated with a delay of RVOT activation and always coincided with the appearance of the AP notch recorded from RVOT epicardium. All repolarization defects giving rise to VT/VF in the BrS and ERS models were reversed by acacetin, resulting in total suppression of VT/VF.ConclusionsWe present experimental models of BrS and ERS capable of recapitulating all of the ECG and arrhythmic manifestations of the JWS. Our findings provide definitive support for the repolarization but not the depolarization hypothesis proposed to underlie BrS and point to acacetin as a promising new pharmacologic treatment for JWS.
The uterine pathological features associated with sentinel lymph node metastasis in endometrial carcinomas
Authors: Kang Yuna , Kim Teresa H. , Gjertson David W. , Cohen Joshua G. , Memarzadeh Sanaz , Moatamed Neda A. 
Published: November 2020

Background
In recent years, sentinel lymph node excision and ultrastaging have been performed in endometrial carcinomas to obtain information about lymph node status, avoiding unnecessary complete pelvic and paraaortic lymphadenectomy. The purpose of this retrospective study was to provide a comprehensive evaluation of the pathological features of endometrial carcinomas and their significance in association with sentinel lymph node involvement.

Methods
Patients with endometrial carcinomas, preceded by sentinel lymph node mapping, were classified into Group-I and Group-II with negative and positive involvement, respectively. The pathological features, associated with sentinel lymph node involvement, were statistically analyzed, including determination of test performance parameters.

Results
Among 70 patients who had undergone hysterectomy and sentinel lymph node excision, 61 had carcinoma and 9 had atypical hyperplasia. There were 50 patients in Group-I and 10 in Group-II. In Group-II, the significant pathological features were: 1) lower uterine segment involvement (100%), 2) an average tumor size of ≥5 CM, 3) lymphovascular invasion (50%), 4) cervical stromal invasion (40%), and 5) depth of myometrial invasion of ≥50% (50%). The incidences of these pathological features were significantly less in Group-I. Statistical analyses singled out “lower uterine segment involvement” as the most important feature.

Conclusions
We have identified five pathological features which are associated with sentinel lymph node involvement. Since lower uterine segment involvement has occurred in all cases of the Group-II cohort, we recommend FIGO and other organizations that determine staging rules should consider whether tumors that involve the lower uterine segment should be staged as higher than “1a”, if the findings in this small series are confirmed by other studies. The results of this study may guide pathologists and oncologists in the diagnostic and therapeutic approaches to management of endometrial carcinomas.
Psychosocial and socio-environmental factors associated with adolescents’ tobacco and other substance use in Bangladesh
Authors: Khan Md. Mostaured Ali , Rahman Md. Mosfequr , Jeamin Syeda S. , Mustagir Md. Golam , Haque Md. Rajwanul , Kaikobad Md. Sharif 
Published: November 2020

BackgroundTobacco, alcohol, and marijuana are the top three substances used by adolescents. The adverse health effects of these three substances are well documented in epidemiological literature, yet little is known about the substance use and associated factors among adolescents in Bangladesh. This study examines the risk factors for tobacco and other substances use among school-going adolescents in Bangladesh.MethodsWe analyzed data from the 2014 Bangladesh Global School-based Student Health Survey (GSHS) of adolescents aged 13–17 years. We used two outcome measures: tobacco use (TU) and other substance use (SU; alcohol and/or marijuana). We examined a set of reported psychosocial and socio-environmental adverse events as risk factors. Logistic regression analyses were used to identify associations.ResultsThe prevalence of TU and other SU among school-going adolescents was 9.6% and 2.3%, respectively. The likelihood of TU and other SU was higher among adolescents who reported being bullied (TU: adjusted odd ratio [AOR]: 1.93; 95% confidence interval [CI]: 1.24–3.00; and other SU: AOR: 3.43; 95% CI: 1.46–7.99) and having sexual history (TU: AOR: 19.38; 95% CI: 12.43–30.21; and other SU: AOR: 5.34; 95% CI: 2.17–13.29). Moreover, anxiety-related sleep loss was associated with adolescents’ TU (AOR: 2.41; 95% CI: 1.02–5.82) whereas the likelihood of other SU (AOR: 3.27; 95% CI: 1.14–9.44) was higher among lonely adolescents. Experience of adverse socio-environmental factors, such as parental substance use (TU: AOR: 7.81; 95% CI: 5.08–12.01), poor monitoring (TU: AOR: 1.96; 95% CI: 1.16–3.31) and poor understanding (TU: AOR: 2.22; 95% CI: 1.36–3.65), and lack of peer support (TU: AOR: 3.13; 95% CI: 1.84–5.31; and other SU: AOR: 2.45; 95% CI: 1.02–5.91), and truancy (other SU: AOR: 4.29; 95% CI: 1.81–10.12) were also positively associated with TU and/or other SU. Additionally, higher odds of tobacco use were observed among adolescents who reported 1 (AOR: 4.36 times; 95% CI: 1.34–14.24), 2 (AOR: 8.69 95% CI: 1.67–28.23), and ≥3 (AOR: 17.46; 95% CI: 6.20–49.23) adverse psychosocial experiences than who did not report any psychosocial events.ConclusionsTobacco and other substance use among school-going adolescents are prevalent in Bangladesh. Several psychosocial and socio-environmental events are associated with TU and other SU, which should be incorporated into adolescent substance use and health promotion programs.
The Volume-Outcome Effect Calls for Centralization of Care in Esophageal Adenocarcinoma: Results From a Large National Cancer Registry
Authors: Han Samuel , Kolb Jennifer M. , Hosokawa Patrick , Friedman Chloe , Fox Charlie , Scott Frank I. , Lieu Christopher H. , Vajravelu Ravy K. , McCarter Martin , Murphy Caitlin C. , Cook Michael B. , Gleisner Ana , Falk Gary W. , Katzka David A. , Wani Sachin 
Published: November 2020

INTRODUCTION:
Using the National Cancer Database, we assessed the relationship between facility overall esophageal adenocarcinoma (EAC) case volume and survival.

METHODS:
We categorized facilities into volume quintiles based on annual EAC patient volume and performed a multivariable Cox proportional hazards regression between facility patient volume and survival.

RESULTS:
In a cohort of 116,675 patients, facilities with higher vs lower (≥25 vs 1–4 cases) annual EAC patient volume demonstrated improved survival (adjusted hazard ratio: 0.80. 95% confidence interval: 0.70–0.91).

DISCUSSION:
This robust volume-outcome effect calls for centralization of care for EAC patients at high annual case volume facilities.
Pharmacogenetics to Predict Adverse Events Associated With Antidepressants
Authors: Rossow Katelyn M. , Aka Ida T. , Maxwell-Horn Angela C. , Roden Dan M. , Van Driest Sara L. 
Published: November 2020

OBJECTIVES:
To determine the association between cytochrome P450 2C19 (CYP2C19) metabolizer status and risk for escitalopram and citalopram, collectively termed (es)citalopram, and sertraline adverse events (AEs) in children.

METHODS:
In this retrospective cohort study, we used deidentified electronic health records linked to DNA. The cohort included children ≤18 years with ≥2 days of (es)citalopram or ≥7 days of sertraline exposure. The primary outcome was AEs assessed by manual chart review. CYP2C19 was genotyped for functional variants (*2, *3, *4, *6, *8, and *17), and individuals were assigned metabolizer status. Association between AEs and metabolizer status was determined by using Cox regression adjusting for age, race, ethnicity, dose, and concomitant CYP2C19-inhibiting medications.

RESULTS:
The cohort included 249 sertraline-exposed and 458 (es)citalopram-exposed children, with a median age of 14.2 years (interquartile range 11.2–16.2) and 13.4 years (interquartile range 10.1–15.9), respectively. Sertraline AEs were more common in normal metabolizers (NMs) compared to poor metabolizers (PMs) or intermediate metabolizers (IMs) (hazard ratio [HR] 1.8; 95% confidence interval [CI] 1.01–3.2; P = .047) in unadjusted analysis and after adjustment (HR 1.9; CI 1.04–3.4; P = .04). For (es)citalopram, more AEs were observed in NMs than PMs and IMs without statistically significant differences (unadjusted HR 1.6; CI 0.95-2.6; P = .08; adjusted HR 1.6; CI 0.95-2.6; P = .08).

CONCLUSIONS:
In contrast to adults, in our pediatric cohort, CYP2C19 NMs experienced increased sertraline AEs than PMs and IMs. (Es)citalopram AEs were not associated with CYP2C19 status in the primary analysis. The mechanism underlying this pediatric-specific finding is unknown but may be related to physiologic differences of adolescence. Further research is required to inform genotype-guided prescribing for these drugs in children.
Relationship between availability of basic amenities and proportion of Slum population in Maharashtra
Authors: Dr. Sakreen Hasan  
Published: November 2020

The urban centers offering diverse employment opportunities and means of livelihood are the main centers of attraction for migration. But the availability of infrastructure is low to accommodate the invariably growing population. The access to basic amenities like electricity, drinking water, toilet facility, wastewater outlet and clean fuel are critical determinants of quality of urbanization. And if it lacks, then it would facilitates the growth of slum. In this paper it being tried to capture the interdependent relationship between basic amenities and slum population residing in the class I towns in Maharashtra; largest slum populated state of India. As the slum is all about the situation or condition in which the people of medium and lower strata are living.
A detailed analysis of proportion of slum population and availability of amenities which includes good housing condition, treated tap water as the source of drinking water, electricity as the source of lightning, households having latrine and bathing facility within the premises, waste water outlet connected to closed drainage, and households availing the banking facilities. This may be a limitation of the study that only these indicators have been taken to assess the availability of amenities and to calculate the amenity index of class I towns of the state of Maharashtra.
To achieve the sustainable development goal (Sustainable cities and communities), we have to control the growth of slum population and to combat the formation of slum; we have to analyze the situation of basic infrastructure provided in urban centers. Amenities and slum population has policy implications as to reduce the slum population, provide basic amenities to the households which will improve their standard of living and ultimately lead to reduction in growth of slum and check the future slum formation.
Türk Kütüphaneciliğinin Kişisel, Kurumsal ve Entelektüel Bilgi Birikimini Derleme Çalışmaları ve Elektronik Erişim Olanakları
Authors: Toplu Mehmet 
Published: November 2020

Kişisel, kurumsal ve entelektüel bilgi birikimi, bir bilim ve/veya meslek dalının tanımlanmasında, gelişim koşullarının saptanmasında en önemli araçların başında gelmektedir. Bilginin yayımından erişimine kadar geçen sürecin her aşamasında yetkili ve sorumlu olan kütüphaneciler, aynı zamanda kendi kişisel, kurumsal ve entelektüel bilgi birikimine erişmeye olanak sağlayacak araç ve ortamları yaratmakla yükümlüdürler.
Türkiye’de bilginin erişiminde karşılaşılan birçok temel sorunun kütüphanecilik alanında da yaşandığı gözlenmektedir. Kütüphaneciler, kişisel, kurumsal ve entelektüel bilgi birikiminin erişimine olanak sağlayacak araç ve ortamları etkin bir biçimde yaratabilmiş değildir. 2006 yılında bu sorunlara çözüm üretebilmek amacıyla Üniversite ve Araştırma Kütüphanecileri Derneği (ÜNAK) öncülüğünde bir proje başlatılmıştır. Bu proje ile, Türkiye’deki kütüphanecilik alanıyla ilgili kişisel, kurumsal ve entelektüel bilgi birikimine elektronik ortamda erişim hedeflenmiş ve bu amaçla 2006 yılında “Türkiye’de Kütüphanecilikte Kim Kimdir” adlı proje elektronik ortamda uygulamaya konulmuştur. 2007 yılından itibaren “Türkiye Bilgi Merkezleri Rehberi” yine elektronik ortamda hazırlanmaya başlanmıştır. Projenin üçüncü aşamasında; kütüphanecilik alanında üretilmiş olan raporlar, bildiriler, vb. elektronik ortamda erişilebilir hale getirilmeye çalışılacaktır.
INDUSTRY 4.0 AND THE CIRCULAR ECONOMY: ARE THESE INTEGRATED OR DISJOINTED CONCEPTS? A RESEARCH AGENDA
Authors: Agudo Fabiana Liar , Gobbo Júnior José Alcides , Oliveira Gobbo Simone Cristina de 
Published: November 2020

Purpose - To analyze whether the concepts of industry 4.0 and the circular economy are integrated or disjointed, recognizing which keywords are most used in the literature regarding this relationship and the occurrence. Design/methodology/approach – A bibliometric study and keyword study were used to recognize which were the most latent actions and strategies in the study of integration. The software VOSviewer was used to study the keywords.Findings - The concepts of industry 4.0 and the circular economy can be considered interconnected, with some limitations explored in the article, along with proposed future research opportunities on the subject.Originality/value - This study contributes to business managers in the sense that it facilitates an understanding that industry 4.0 and the circular economy can be used together. The result of the keywords identifies which skills, strategies, technologies and fundamentals the company should develop to make the circular economy effective, through industry 4.0. For academic research, another study has contributed to the integration of industry 4.0 and the circular economy, which is not found very often in the literature. Keywords were also mapped, which, until now, had not been developed in existing articles on integration, in addition to proposing a framework that can be transformed and suggesting research opportunities.Keywords - Industry 4.0; Circular Economy; Integration; Sustainability; Future research.
KAJIAN PERKEMBANGAN SISTEM PETANDA PADA ARSITEKTUR DAN INTERIOR RUANG PUBLIK DI DENPASAR MENUJU DENPASAR KOTA KREATIF
Authors: Rahayu Ni Nyoman Sri , Swari Luh Gde Niti 
Published: November 2020

Abstract: The conservation of cultural heritage, especially the identity of traditional architecture in the city of Denpasar, is an effort to strengthen the architectural character of Denpasar. The uniqueness of Denpasar architecture is the peciren bebadungan while the red brick pattern. This also gives an identity to the architectural fasade of Denpasar as a creative city that is appear with local traditions and culture. The signage is one of the important architectural and interior elements and becomes the vocal point. This is due to its function which is visually in front of (building facade), which functions to provide information related to the building. The research method used is descriptive-qualitative method, with the selection of objects using purposive sampling technique. The result of the research is that the signage design does not reflect the strong character of Denpasar architecture. There are two most basic things, which become the main criteria, that was the use of the peciren bebadungan (the form of a red brick pattern arranged) in such as a unique of Denpasar architecture that is different from architecture in another regencies in Bali. The second is the use of Balinese script as a local Balinese identity. These two things are what the authors prioritize in designing, so that creative signage and local wisdom is created.Keywords: signage, local genius, public space, creative city.Abstrak: Peneguhan kembali warisan budaya khususnya jatidiri arsitektur tradisional di kota Denpasar merupakan salah satu usaha untuk memperkuat karakter arsitektur Denpasar. Keunikan arsitektur kota Denpasar yang khas (peciren bebadungan berupa pola susun maju mundur material bata merah). Hal ini pula yang memberi identitas bagi wajah arsitektur kota menuju Denpasar sebagai kota kreatif yang selaras dengan tradisi dan budaya local setempat. Sistem petanda atau signage merupakan salah satu elemen arsitektur dan interior yang penting dan menjadi titik focus pengamat dan pengguna bangunan. Hal ini dikarenakan fungsinya yang secara visual berada di muka (fasade bangunan), berfungsi memberikan informasi terkait bangunan. Metode penelitian yang digunakan adalah metode deskriptif-kualitatif, dengan pemilihan objek menggunakan teknik purposive sampling. Hasil penelitian adalah desain signage belum mencerminkan karakter arsitetur Denpasar yang kuat. Terdapat dua hal yang paling mendasar, yang menjadi kriteria utama yakni penggunaan bentuk peciren bebadungan yakni bentuk pola susun maju mundur bata merah yang disusun sedemikian rupa sebagai bentuk khas Arsitektur Denpasar yang unik dan berbeda dengan Kabupaten lainnya di Bali. Yang kedua adalah penggunaan aksara Bali sebagai identitas local Bali. Dua hal ini yang penulis utamakan dalam perancangan, sehingga tercipta signage yang kreatif dan berkearifan local. Kata Kunci: sistem petanda, kearifan local, ruang public, kota kreatif.
Building the Bridge Between Schools and Families through Assessment of Young English Language Learners
Authors: Pratt David 
Published: November 2020

Teachers of English Language Learners have a unique opportunity to connect with families through observation, documentation, and assessment of these children. Using a developmentally appropriate and asset-based approach, assessment information can be collected and shared with families to engage them in the learning process. This article provides the practical steps of using a variety of primarily formative assessment methods by which teachers of ELL's can build this vital bridge to families successfully.
Frequency of Epstein Barr virus infection among Sudanese children patients with Burkitt’s lymphoma
Authors: Muddathir Abdel Rahim Mahmoud , Elradi Wala Eldin Osman , Yousif Badreldin , Abd allah Elharam Ibrahim 
Published: November 2020

Background: Burkitt's lymphoma (BL) is a B-cell malignancy categorized in three forms endemic, sporadic, and immunodeficiency-associated variants. Epstein barr virus (EBV) is associated with BL in almost all African populations. The frequency of EBV associated with BL is unknown in Sudan. The study aimed to estimate the frequency of EBV in Sudanese patients with BL.Methods: The study was a descriptive cross-sectional study conducted between June 2014 and July 2019 in 34 paraffin-embedded tissue sections obtained from diagnosed BL patients attending Soba university hospital in Khartoum city (Sudan). Monoclonal IgG1 antibody was used to detect EPV by immunohistochemistry technique.Results: The study showed that 44.1% (15/34) of BL patients were positive for EBV, whereas 55.9% (19/34) showed negative EBV. Males, 66.7% (10/15) were more affected by the EBV infection than females, 33.3% (5/15). P value=0.014. Conclusions: Despite BL is considered a rare type of lymphoma in Sudan; the obtained results showed a lower frequency of EBV compared with other studies worldwide.