bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the Italian version of the Revised Prenatal Coping Inventory (NuPCI) and its correlations with Pregnancy-Specific Stress.
Authors: Penengo Chiara , Colli Chiara , Garzitto Marco , Driul Lorenza , Cesco Maddalena , Balestrieri Matteo 
Published: August 2020

Abstract
Background: Pregnancy is a period of happiness but also of physical and psychological changes that can lead to distress. Functional coping strategies can reduce the pregnancy specific-stress. This study aimed to assess the psychometric properties of the Revised Prenatal Coping Inventory (NuPCI) in an Italian sample and to investigate how coping strategies were associated with pregnancy-specific stress.Methods: In this cross-sectional study, low-risk pregnant women (N=211) were assessed with NuPCI, NuPDQ (Revised-Prenatal Distress Questionnaire), Brief-COPE (Coping Orientation to the Problems Experienced), and STAI (State-Trait Anxiety Inventory). The reliability of NuPCI was evaluated by assessing its internal consistency and factor structure (with a Confirmatory Factor Analysis, CFA). The concurrent validity between NuPCI and Brief-COPE and NuPDQ and STAI was investigated. Lastly, the relationship between NuPCI and NuPDQ was analyzed, as well as the ability of these scales to predict Apgar score at birth.Results: Internal consistency of NuPCI scales was good for Planning-Preparation (ɑC=0.84) and Spiritual-Positive Coping (ɑC=0.81) scales, acceptable for Avoidance (ɑC=0.76) scale. Moreover, the original three-factor structure was confirmed using a Confirmatory Factor Analysis with 29 of the 32 items (χ2374=618.06; RMSEA=0.056, 95% confidence interval: [0.048, 0.063]); CFI=0.920; and TLI=0.913). Statistically significant correlations between NuPCI scales and Brief-COPE subscales ranged between r=+0.217 and r=+0.624; also, NuPDQ score was positively correlated with STAI scales (State scale: r=+0.539; Trait scale: r=+0.462). Concurrent validity was confirmed reporting that NuPDQ score was predicted by NuPCI scores (R2=0.423, p<0.001), positively by Avoidance (β=+0.572) and Planning-Preparation (β=+0.215) and negatively by Spiritual-Positive Coping (β=-0.132). Finally, considering the stress, the effect of the Avoidance and Spiritual-Positive Coping scores respectively in decreasing (+155%) and increasing (+16%) the Apgar score became stronger.Conclusions: Italian NuPCI has sound psychometric properties and it is a useful coping measure. NuPDQ showed also a good validity. Our results may suggest a significant role for coping strategies, particularly in modulating the condition of the newborn at birth.
Association of alanine transaminase to aspartate aminotransferase ratio and incident diabetes in Chinese adults: a second retrospective cohort study
Authors: Liang Zhilin , Hu Haofei , Wang Xunxun , Chen Xianxiong , Liu Zhigang , Zhang Min 
Published: August 2020

Abstract
Background : Previous studies have indicated that serum alanine aminotransferase ( ALT ) level, serum aspartate aminotransferase ( AST ) level or ALT/AST ratio may be bound up with diabetes. But the association of ALT/AST ratio and incident diabetes in Chinese adults have not been elaborated yet. The main objective of the present study was to analyze whether ALT/AST ratio was an independent risk factor which attached to the risk of incident diabetes in Chinese adults. Methods: From 2010 to 2016, 685,277 Chinese adults who received a health check in Rich Healthcare Group including all medical records, and the present article was a second retrospective cohort analysis based on above population. As the target independent variable, ALT/AST ratio was measured at baseline while the dependent variable, incident diabetes appeared during follow-up. We used Cox proportional hazard regression models to analyze the prognostic value of ALT/AST on the risk of incident diabetes. Results: ALT/AST demonstrated undeniable correlation with incident diabetes (HR=2.535, 95%CI: 2.190 to 2.934, P <0.00001). The association between ALT/AST and incident diabetes is only linear. The cumulative incidence (95% CI) rate of incident diabetes in total participants, ALT/AST quartile 1, 2, 3, and 4 was 2.112 (2.016-2.208), 0.992 (.0.857-1.127), 1.430 (1.274-1.586), 2.396 (2.192-2.600) and 3.559 (3.314-3.803), separately. The population with age (30 to <40 years), BMI (<24kg/m2) and SBP (<140mmHg) was found to be the stronger association in subgroup analysis. Conclusion: In Chinese adults, ALT/AST ratio is an independent risk factor for incident diabetes .
Retrospective cohort study on radial head arthroplasty comparing long-term outcomes between valgus type injury and fracture dislocation
Authors: Chen Alvin Chao-Yu , Weng Chun-Jui , Chiu Chih-Hao , Chang Shih-Sheng , Cheng Chun-Ying , Chan Yi-Sheng 
Published: August 2020

Abstract
Background: Radial head arthroplasty (RHA) has been commonly adopted for irreparable radial head fractures while little information is addressed on valgus type injury. The purpose of this study is to report long-term outcomes and radiographic analysis in RHA for valgus type injury with comparison to fracture dislocation injury.Methods: A retrospective cohort study was conducted in patients receiving unilateral RHA with loose-fit, modular metal prosthesis for irreparable radial head fractures between 2004 and 2012. Totally, 33 patients with a mean follow up of nine years (range, 7 to 15 years) were enrolled and divided into two groups including 14 valgus injuries and 19 fracture-dislocations. Demographics of the patients, injury details, clinical and radiographic outcomes, and correlation analysis were investigated and compared between two groups.Results: In patient demographics, significant difference was noted in sex distribution, lateral collateral ligament involvement and time from injury to RHA between two groups. No patient underwent subsequent removal or revision of prosthesis. Good to excellent results according to Mayo Elbow Performance Score (MEPS) was achieved in 13 and 14 patients in group A and B respectively. Final motion range and Disabilities of the Arm, Shoulder, and Hand score was significantly better in valgus injury group. Radiographic analysis demonstrated fewer patients in valgus injury group presented periprosthetic osteolysis with weak to moderate negative correlation between radiolucency score and MEPS.Conclusions: With an average of nine years follow-up, RHA using loose-fit, modular metal prosthesis achieves encouraging outcomes for both valgus injury and fracture dislocation. In valgus type injury, better motion range, lower disability score and lower incidence of periprosthetic osteolysis is noted while correlation analysis of radiolucency score suggests extended, long-term investigation.
A Genetic Predictive Model for Precision Treatment of Diffuse Large B-cell Lymphoma with Early Progression
Authors: Ma Jialin , Yan Zheng , Zhang Jiuyang , Zhou Wenping , Yao Zhihua , Wang Haiying , Chu Junfeng , Yao Shuna , Zhao Shuang , Zhang Peipei , Xu Yuanlin , Xia Qingxin , Ma Jie , Wei Bing , Yang Shujun , Liu Kangdong , Guo Yongjun , liu yanyan 
Published: August 2020

Abstract
Background: Early progression after the first-line R-CHOP treatment leads to a very dismal outcome and necessitates alternative treatment for patients with diffuse large B-cell lymphoma (DLBCL). This study aimed to develop a genetic predictive model for early progression and evaluate its potential in advancing alternative treatment. Methods: Thirty-two hotspot driver genes were examined in 145 DLBCL patients and 5 DLBCL cell lines using next-generation sequencing. The association of clinical features, cell-of-origin, double expression, positive p53 protein, and gene alterations with early progression was analyzed, and the genetic predictive model was developed based on the related independent variables and assessed by the area under receiver operating characteristic. The potential of novel treatment based on the modeling was investigated in in vitro DLBCL cell lines and in vivo xenograft mouse models. Results: The frequency of CD79B (42.86% vs 9.38%, p = 0.000) and PIM1 mutations (38.78% vs 17.71%, p = 0.005) showed a significant increase in patients with early progression. CD79B and PIM1 mutations were associated with complex genetic events, double expression, non-GCB subtype, advance stage and unfavorable prognosis. A powerful genetic predictive model (AUROC = 0.771, 95% CI: 0.689-0.853) incorporating lactate dehydrogenase levels (OR = 2.990, p = 0.018), CD79B mutations (OR = 5.970, p = 0.001), and PIM1 mutations (OR = 3.021, p = 0.026) was created and verified in the other cohort. This modeling for early progression outperformed the prediction accuracy of conventional International Prognostic Index, and new molecular subtypes of MCD and Cluster 5. CD79B and PIM1 mutations indicated a better response to inhibitors of BTK (ibrutinib) and pan-PIM kinase (AZD 1208) through repressing activated oncogenic signaling. Since the two inhibitors failed to decrease BCL2 level, BCL2 inhibitor (venetoclax) was added and demonstrated to enhance their apoptosis-inducing activity in mutant cells with double expression. Conclusions: The genetic predictive model provides a robust tool to identify early progression and determine precision treatment. These findings warrant the development of optimal alternative treatment in clinical trials.
Associations of physical performance and physical activity with mental well-being in middle-aged women
Authors: Bondarev Dmitriy , Sipilä Sarianna , Finni Taija , Kujala Urho M. , Aukee Pauliina , Kovanen Vuokko , Laakkonen Eija , Kokko Katja 
Published: August 2020

Abstract
Purpose
To investigate the associations of physical performance with positive and negative dimensions of mental well-being in middle-aged women and to explore the role of physical activity (PA) in these associations.
Methods
Women aged 47–55 (n = 909) participated in measurements of physical performance (handgrip force, knee extension force, vertical jumping height, maximal walking speed, and six-minute walking distance). Both mental well-being (the Centre for Epidemiologic Studies Depression Scale, the International Positive and Negative Affect Schedule Short Form and the Satisfaction with Life Scale) and PA were self-reported. Associations between variables were analysed using multivariate linear regression modelling adjusted for body height, fat mass, menopausal status and symptoms, marital status, parity, employment status, self-reported mental disorders, and use of psycholeptics and psychoanaleptics. PA was then entered into a separate model to explore its role in the associations.
Results
In the adjusted models, significant positive associations of six-minute walking distance with positive affectivity (B = 0.12, p = 0.002) and life satisfaction (B = 0.15, p = 0.033) were observed. No significant associations were observed between physical performance and depressive symptoms or negative affectivity. PA was positively associated with positive affectivity and life satisfaction and negatively with depressive symptoms across all the physical performance predictors.
Conclusion
Of the physical performance measures, six-minute walking distance was associated with positive mental well-being independently of PA level. In addition to PA, aerobic component of physical performance is especially beneficial for positive mental well-being in middle-aged women.
Effect of Local Steroid Injection for Acute Anterior Talofibular Ligament Partial Tear: A Randomized Trial
Authors: Liu Chung-Ting , Yang Ten-Fang , Chen Wei-Cheng 
Published: August 2020

Abstract
Background: The symptoms of acute ankle anterior talofibular ligament (ATFL) partial tear includes pain, swelling, and range of motion limitation. Local steroid injection can provide strong anti-inflammatory effect. The aim of the study is to evaluate the effectiveness and complications of local steroid injection for acute ATFL partial tear in short term.Materials and Methods:This is a prospective randomized study. Forty patients with acute isolated ATFL partial tear diagnosed by sonography were equally separated into two groups. The steroid group received 1cc Diprospan local injection whereas the control group received 1cc normal saline injection. We used sonography to check the tendon rupture status before injection, 6 weeks and 12 weeks after injection. We also used American Orthopaedic Foot & Ankle Society (AOFAS) score and Pain Visual Analogue Scale (VAS) score to evaluate the function and pain before injection, 1 week, 3 weeks, 6 weeks, and 12 weeks after injection. Student t test was used to compare the statistically significant difference between groups.Result:There was no deteriorating of ATFL tear found by sonography in both groups until 12 weeks. The average AOFAS score was higher than 80 after 1 weeks in steroid group while the score was higher than 80 after 3 weeks in control group. AOFAS score was significantly higher in steroid group for the first 3 weeks after injection (p = 3.2x10-7 and 0.022, at 1 week and 3 weeks respectively), but there was no significant difference between groups afterward. VAS score was significant higher in steroid group only in the first week (p = 0.0073) and there was no significant difference between groups afterward Conclusion:Steroid local injection can safely shorten the period of functional disability and relieve pain for acute ATFL partial tear in short term.Trial registration:ChiCTR, ChiCTR2000029629, registered 07 February 2020http://www.chictr.org.cn/showproj.aspx?proj=49198
Enhanced Tolerance to Drought Stress Resulting from Caragana Korshinskii CkWRKY33 in Transgenic Arabidopsis Thaliana
Authors: Li Zhen , Liang Fengping , Zhang Tianbao , Fu Na , Pei Xinwu , Long Yan 
Published: August 2020

Abstract
Background: It is well known that WRKY transcription factors play important roles in plant growth and development, defense regulation and stress responses.Results: In this study, a WRKY transcription factor, WRKY33, was cloned from Caragana korshinskii. A sequence structure analysis showed that it belonged to the Group-I type. Subcellular localization experiments in tobacco epidermal cells showed the presence of CkWRKY33 in the nucleus. Additionally, CkWRKY33 was overexpressed in Arabidopsis thaliana. A phenotypic investigation revealed that compared with wild-type plants CkWRKY33-overexpressing transgenic plants had higher survival rates, as well as relative water, soluble sugar, proline and peroxidase contents, but lower malondialdehyde contents, following a drought stress treatment. Conclusions: This suggested that the overexpression of CkWRKY33 led to an enhanced drought-stress tolerance in transgenic A. thaliana. Thus, CkWRKY33 may act as a positive regulator involved in the drought-stress responses in Caragana korshinskii.
The Morphology of Patella changed significantly after Soft Tissue Correction for children with Recurrent Patella Dislocation
Authors: Niu Jinghui , Qi Qi , Hao Kuo , Lin Wei , Piao Kang , Wang Fei 
Published: August 2020

Abstract
Background: Although morphological improvement of femoral trochlea has been investigated in children with patella dislocation after surgery, whether the patellar shape changed under the same condition is still unknown. The purpose of the study was to investigate the changes of patella morphology in transverse plane following surgical correction of recurrent patella dislocation in children.Methods: A total of 22 patients with a mean age of 9.9 years (7 to 12) were included. All had unilateral recurrent patella dislocation. The knees with recurrent patella dislocation were treated with medial patellar retinaculum plasty and defined as the study group. The contralateral knees with no symptom of patellar instability were considered as the control group. All patients were treated between October 2014 and August 2018. Axial CT (Computed Tomography) scans were undertaken in all patients to assess the patella morphological characteristics on a particular axial image preoperatively and at the final follow-up.Results: There are not significant differences about patellar transverse diameter, thickness and Wiberg angle between study group and control group before surgery and at the last follow-up respectively ( The mean follow-up period: 28.0 ± 3.3 months). However, before surgery, the Wiberg-index in the study group (0.74 ± 0.06) is significantly different from that in the control group (0.64 ± 0.04). At the last follow-up, the Wiberg-index in the study group (0.67 ± 0.05) and the control group (0.65 ± 0.04) are not significantly different. Also, in the study group, the Wiberg-index at the last follow-up is significantly lower than that before surgery (P ＜ 0.05). The Wiberg-index in the control group is not significantly different before surgery and at the last follow-up. Conclusion: The patella morphology can change significantly after surgical procedures in children (before epiphyseal closure) with patellar recurrent dislocation
Effect of Vitamin C on mortality of critically ill patients with severe pneumonia in intensive care unit
Authors: Mahmoodpoor Ata , Shadvar Kamran , Sanaie Sarvin , Hadipoor Mir Reza , Pourmoghaddam Mohammad Ata , saghaleini seied hadi 
Published: August 2020

Abstract
Background: Critically ill patients are frequently suffering from vitamin C deficiency. Previous studies showed that high doses of vitamin C administration had conflicting results on clinical outcomes in patients with severe sepsis, burns and trauma. Because of high incidence and morbidity/mortality with severe pneumonia, we aimed to investigate the effect of administration of high dose vitamin C in critically ill patients with severe pneumonia.Methods: Eighty critically ill patients with pneumonia were enrolled in this randomized double blinded clinical trial. Patients with CURB-65 score >3, one major criteria, or ≥3 minor criteria were considered as severe pneumonia. Patients were randomly assigned to intervention or placebo groups receiving standard treatment plus 60 mg/kg/day vitamin C as continuous infusion or normal saline in the same volume correspondingly for 96 hours. Serum levels of vitamin C were noted at baseline and 48 hours after vitamin C administration. Duration of mechanical ventilation, ICU length of stay, PaO2/FiO2 and mortality rate were noted for all patients till the 28th day. Any complications related to vitamin C administration were recorded. (IRCT registration number: IRCT20190312043030N1 , Registration date: 2019-08-26, seied hadi saghaleini).Results: Duration of mechanical ventilation and vasopressor use were significantly lower in intervention group (p: <0.001 and 0.003, respectively). Baseline levels of vitamin C in both groups did not have significant difference but its levels increased in intervention group and decreased in control group during the study period. Mortality rate insignificantly decreased in intervention group (p: 0.17). Three patients showed hypotension and tachycardia during the administration of vitamin C which was self-limited with decreasing the dose of vitamin C.Conclusion: Our results showed that the intravenous administration of a relatively high dose of vitamin C to critically ill patients with severe pneumonia was safe and could decrease the inflammation, mechanical ventilation duration and vasopressor use without any significant effect on mortality.
Vagus Nerve Stimulation Ameliorates L-NAME-induced Preeclampsia-like Symptoms in Rats Through Inhibition of the Inflammatory Response
Authors: Zheng Linmei , Tang Rong , Shi Lei , Zhong Mei , Zhou Zhongyi 
Published: August 2020

Abstract
Background Preeclampsia is characterized by an excessive inflammatory response. Recent studies have shown that vagus nerve stimulation (VNS) has anti-inflammatory properties in vivo. This study aims to investigate whether VNS is safe for use during pregnancy and to explore the therapeutic potential and underlying mechanisms of VNS in PE. Methods Pregnant Sprague-Dawley rats were randomly chosen to receive N-nitro-L-arginine methyl ester (L-NAME)-containing water (preeclampsia-like mouse model) or saline (normal pregnancy control) daily at gestational days 14.5-20.5. VNS and the α7nAChR antagonist methyllycaconitine citrate (MLA, 1 mg/kg/d) were given daily at the same time.Results VNS decreased the high systolic blood pressure and urinary protein observed in the PE rats. In addition, VNS mitigated abnormal pregnancy outcomes. Moreover, VNS alleviated the inflammatory response by decreasing the levels of inflammatory cytokines. VNS significantly increased the expression of α7nAChR and attenuated the activation of NF-κB p65 in the placenta.Discussion Our findings indicate that maternal VNS treatment is safe during pregnancy and has a protective effect in a pregnant rat model of preeclampsia induced by L-NAME.
Effect of Intrapartum Fever Associated With Epidural Analgesia on Short-Term Maternal and Neonatal Outcomes in Nulliparous Women: A Case Control Study
Authors: Zeng Huiqian , Lin Baohua , Zhang Huizhu , Guo Kaimin , He Ping , Lai Yumian 
Published: August 2020

Abstract
BackgroundThe effects of intrapartum fever associated with epidural analgesia in nulliparous women on the short-term maternal and neonatal outcomes are not well understood.Methods We included 2076 nulliparous women who received regular obstetric examination and gave birth at Guangzhou Women and Children’s Medical Center from January 1, 2020 to June 30, 2020. All cases were singleton full-term pregnancies, and all foetuses were in cephalic presentation. We allocated 817 women with temperature >38℃ during labour into the fever group and 1259 women with temperature ≤38℃ during labour to the non-fever group. The short-term maternal and neonatal outcomes in the two groups were compared. Results in the fever group, 8.3% of pregnant women converted to caesarean delivery. The conversion rate in the non-fever group was 5.2% (p = 0.004). The rates of mild neonatal asphyxia, severe neonatal asphyxia, and neonatal hospitalisation in the fever group were higher than those in the non-fever group (χ2 = 12.070, 6.325, and 6.821, respectively, all P<0.05). The 1194 pregnant women in the fever group who had vaginal deliveries spent 756.46 ± 256.43 minutes in the first stage of labour and 65.74 ± 47.63 minutes in the second stage, significantly longer than the 749 women who had vaginal deliveries in the non-fever group (P<0.001, P=0.001). The assisted delivery rate for vaginal delivery in the fever group was 49.0%, significantly higher than that in the non-fever group (2=49.738, P<0.001). The rates of mild neonatal asphyxia, severe neonatal asphyxia, neonatal acidosis, and neonatal hospitalisation with vaginal delivery in the fever group were higher than those in the non-fever group (2=15.375, 6.597, 22.265, and 7.322, respectively, and p<0.001, 0.010, <0.001, and 0.007, respectively).Conclusions Epidural analgesia-associated intrapartum fever in nulliparous women increased the rates of short-term adverse maternal and neonatal outcomes, indicating that efforts are needed to prevent incidence of intrapartum fever due to administration of epidural analgesia.