bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detachment of Porites cylindrica nubbins by herbivorous fishes
Authors: Quimpo Timothy J. R. , Cabaitan Patrick C. , Hoey Andrew S. 
Published: November 2019

A form of active restoration for coral assemblages involves culturing coral nubbins at nursery sites before transplantation to recipient reefs. Incidental grazing and/or directed predation by local fish assemblages are major sources of dislodgement and mortality for coral nubbins in nurseries. However, the rate of coral nubbin detachment, how this varies across fish taxa, and whether nubbin size affects rates of detachment warrant further investigation. We used field and aquaria experiments to examine the effect of incidental grazing and predation on the detachment of Porites cylindrica nubbins of different sizes (0.5, 1, 2, 3, 4, and 5 cm height). Short‐term (6 hours) exposure of nubbins to local fish assemblages at Lucero Reef, northwestern Philippines, caused higher detachment (1.93% ± 0.53 SE) compared to caged controls (0.16% ± 0.16 SE), with no detectable effect of nubbin size. To identify the impact of individual fish species, nubbins were exposed to one of four locally abundant herbivorous and corallivorous fish species in aquaria for 8 hours. Nubbin detachment was greater when exposed to Chlorurus spilurus (1.20–36.2%) and Siganus fuscescens (0.00–15.0%) than Chaetodon lunulatus (0.00–4.00%) and Chaetodon kleinii (0.00–1.20%), with the smallest nubbins (0.5 cm) being the most vulnerable. Our results suggest that incidental grazing by herbivorous fishes, especially parrotfishes, may potentially be an important source of detachment and likely mortality of nubbins. Optimizing coral nursery protocols should consider potential trade‐offs between excluding grazing fishes and the accumulation of algal material on caging structures to minimize nubbin mortality and improve coral restoration success.
A novel nonsense mutation found in the CD177 gene of Thai individuals with the HNA‐2 null phenotype
Authors: Siriphanthong Kanokpol , Petvises Sawang , Thanongsaksrikul Jeeraphong , Intharanut Kamphon , Nathalang Oytip 
Published: November 2019

SummaryObjectivesThe aim of this study is to explore the molecular basis and to develop a simple sequence‐specific primer polymerase chain reaction (PCR‐SSP) technique for screening genotypes associated with the human neutrophil antigen‐2 (HNA‐2) null phenotype among Thai blood donors.BackgroundSingle‐nucleotide polymorphisms (SNPs) c.787A>T of the CD177 gene is well known to be primarily demonstrated as a genetic determinant for HNA‐2 deficiency.MethodsThe SNPs in the CD177 gene (exons 7 and 9) of 49 Thai blood donors with the known percentage of CD177 expression by flow cytometry including 48 HNA‐2 positive and 1 HNA‐2 null individuals were identified by long‐range PCR amplification and sequencing. Moreover, screening for the c.1254G>A mutation was developed using an in‐house PCR‐SSP technique and tested among 771 unrelated donor samples.ResultsA HNA‐2 null sample from the first cohort was heterozygous for c.787A/T and homozygous for c.1291G/G, namely, a 787A‐1291G/787T‐1291G (AG/TG) genotype. Interestingly, we could identify SNP c.1254G>A (rs188387562, p. Trp418Ter) that caused a nonsense mutation of the CD177 gene in exon 9. This individual might have the 787A‐1254A‐1291G/787T‐1254G‐1291G genotype. From the second cohort (771 unrelated donors), the 1254GG homozygote was the most common (96.37%), followed by the 1254GA heterozygote (3.50%) and 1254AA homozygote (0.13%). Blood samples of two individuals with 787AT‐1254GA‐1291GG and 787AA‐1254AA‐1291GG genotypes were tested and the HNA‐2 antigen expressions were 0.03% and 0.16% in rank.ConclusionsThe c.787A>T is a primary genetic hallmark to determine the HNA‐2 null phenotype. Additional screening of the novel c.1254G>A in combination with c.787A>T is a suitable, convenient and effective diagnosis among Thais.
Active cooling temperature required to achieve therapeutic hypothermia correlates with short‐term outcome in neonatal hypoxic‐ischaemic encephalopathy
Authors: Mietzsch Ulrike , Radhakrishnan Rupa , Boyle Frances A. , Juul Sandra , Wood Thomas R. 
Published: November 2019

Key points
Hypoxic‐ischaemic encephalopathy (HIE) affects 2–4/1000 live term births. Treatment with therapeutic hypothermia (TH) improves the long‐term neurodevelopmental outcome of neonates with moderate to severe HIE. However, early prediction of outcome still remains challenging, and no reliable and easily obtainable biomarker has been identified to date.
Neonates with HIE display impaired thermoregulation, resulting in spontaneous hypothermia. The degree of cooling required to achieve TH may therefore act as a biomarker of injury severity.
The present study demonstrates a correlation between servo‐controlled mattress temperature during TH and short‐term outcome. Neonates with an unfavourable outcome require less cooling to maintain a core temperature between 33 and 34°C during TH compared to neonates with a favourable outcome. The degree of impaired temperature regulation was strongly associated with a high magnetic resonance imaging injury score and death.
Cooling device output temperature is a potential and easily obtainable early physiological biomarker of outcome in infants with HIE undergoing TH.
AbstractNeonatal hypoxic‐ischaemic encephalopathy (HIE) is a leading cause of death and disability in children. Therapeutic hypothermia (TH) at 33.5°C for 72 h is the only therapy to date shown to improve outcome in moderate to severe HIE; however, assessment of severity and prediction of outcome remains challenging. Infants with HIE display significant physiological perturbations, including spontaneous hypothermia. We hypothesized that neonates with more severe brain injury on magnetic resonance imaging (MRI) would exhibit a greater degree of spontaneous hypothermia, and thus require less active cooling to attain TH. Twenty‐eight neonates with moderate or severe HIE treated with TH were included in the present study. MRI images obtained on day of life 4–7 were scored according to standardized injury criteria. Unfavourable outcome was defined as death or significant grey matter injury on MRI according to a previously validated scoring system. A significantly higher cooling device output temperature was seen in infants with an unfavourable outcome. All neonates who required the mattress to provide a temperature ≥32°C to maintain their core body temperature at 33.5°C had a high likelihood of unfavourable outcome (likelihood ratio = 14.4). By contrast, infants who never required a device output temperature ≥32°C had a low likelihood of an unfavourable outcome (likelihood ratio = 0.07, P < 0.001). Infants with significant grey matter injury on MRI require less active cooling to maintain target temperature during TH. The cooling device output temperature has the potential to be an easily accessible physiological biomarker and predictor of injury and mortality in neonates with moderate or severe HIE.
Effects of field-applied fungicides, grain moisture, and time on deoxynivalenol during postharvest storage of winter wheat grain
Authors: Bolanos-Carriel Carlos , Wegulo Stephen N. , Hallen-Adams Heather , Baenziger P. Stephen , Eskridge Kent M. , Funnell-Harris Deanna , McMaster Niki , Schmale David G. 
Published: November 2019

Fusarium head blight, caused mainly by Fusarium graminearum Schwabe, results in major losses in wheat. In two separate field experiments, spikes of winter wheat cultivars ‘Overland’ (moderately resistant) and ‘Overley’ (susceptible) were sprayed at anthesis with the triazole fungicide Prosaro (prothioconazole + tebuconazole) or the strobilurin fungicide Headline (pyraclostrobin) or not sprayed. Following harvest, deoxynivalenol (DON) concentrations were monitored during 120 d of grain storage at 10 °C, 40% relative humidity, and 10%, 16%, or 20% grain moisture. In ‘Overland’, DON decreased significantly at P = 0.05 from an average of 3.6 to 3.0 μg g−1 in the check and decreased from 2.7 to 2.2 μg g−1 in the Prosaro treatment. DON did not significantly decrease (4.4–4.1 μg g−1) in the Headline treatment. DON concentrations did not differ between 16% (3.1 μg g−1) and 20% (3.0 μg g−1) grain moisture. In ‘Overley’, DON increased significantly from 3.1 to 3.6 μg g−1 in the check and from 2.9 to 3.5 μg g−1 in the Headline treatment, but remained the same at 2.2 μg g−1 in the Prosaro treatment. DON concentrations were not different between 16% (3.2 μg g−1) and 20% (3.1 μg g−1) grain moisture but were significantly lower (2.7 μg g−1) at 10% grain moisture. These results indicate that the effects of fungicides applied at anthesis in the field can impact DON concentrations through grain storage. Triazoles are recommended over strobilurins to achieve this extended postharvest protection from DON, and grain moisture during storage should be below the maximum safe level of 13.5% at 10 °C.
Topological insulators and the Kane–Mele invariant: Obstruction and localization theory
Authors: Bunk Severin , Szabo Richard J. 
Published: November 2019

We present homotopy theoretic and geometric interpretations of the Kane–Mele invariant for gapped fermionic quantum systems in three dimensions with time-reversal symmetry. We show that the invariant is related to a certain 4-equivalence which lends it an interpretation as an obstruction to a block decomposition of the sewing matrix up to non-equivariant homotopy. We prove a Mayer–Vietoris Theorem for manifolds with [Formula: see text]-actions which intertwines Real and [Formula: see text]-equivariant de Rham cohomology groups, and apply it to derive a new localization formula for the Kane–Mele invariant. This provides a unified cohomological explanation for the equivalence between the discrete Pfaffian formula and the known local geometric computations of the index for periodic lattice systems. We build on the relation between the Kane–Mele invariant and the theory of bundle gerbes with [Formula: see text]-actions to obtain geometric refinements of this obstruction and localization technique. In the preliminary part we review the Freed–Moore theory of band insulators on Galilean spacetimes with emphasis on geometric constructions, and present a bottom-up approach to time-reversal symmetric topological phases.
Quarter mode rectangular cavity-based perfect metamaterial absorber in the terahertz region
Authors: Lu Xiaojie , Xiao Zhongyin , Chen Mingming 
Published: November 2019

In this work, we present the analysis and design of a perfect metamaterial absorber (MA) based on quarter mode rectangular cavity in the terahertz region. This structure is consisted of a metal plate where three different size quarter mode rectangular cavities are vertically placed on. Based on rectangular-cavity-theory, a formula is proposed to calculate the resonant frequency, which provides a guidance for designing MAs of such type. In terms of normal incidence, the simulated results show that the MA has three resonance points on 4.1301 THz, 4.6051 THz and 5.1088 THz, respectively, which is in good agreement with the calculated results. Furthermore, we present the distribution of E-field in the cavity and use the standing wave theory to explain the physical mechanism of the perfect absorption. These results verify the application of resonant cavities in the field of MA.
Toward the Unification of Physics and Number Theory
Authors: Irwin Klee 
Published: November 2019

This paper introduces the notion of simplex-integers and shows how, in contrast to digital numbers, they are the most powerful numerical symbols that implicitly express the information of an integer and its set theoretic substructure. A geometric analogue to the primality test is introduced: when [Formula: see text] is prime, it divides [Formula: see text] for all [Formula: see text]. The geometric form provokes a novel hypothesis about the distribution of prime-simplexes that, if solved, may lead to a proof of the Riemann hypothesis. Specifically, if a geometric algorithm predicting the number of prime simplexes within any bound [Formula: see text]-simplex or associated [Formula: see text] lattice is discovered, a deep understanding of the error factor of the prime number theorem would be realized — the error factor corresponding to the distribution of the non-trivial zeta zeros, which might be the mysterious link between physics and the Riemann hypothesis [D. Schumayer and D. A. W. Hutchinson, Colloquium: Physics of the Riemann hypothesis, Rev. Mod. Phys. 83 (2011) 307]. It suggests how quantum gravity and particle physicists might benefit from a simplex-integer-based quasicrystal code formalism. An argument is put forth that the unifying idea between number theory and physics is code theory, where reality is information theoretic and 3-simplex integers form physically realistic aperiodic dynamic patterns from which space, time and particles emerge from the evolution of the code syntax.
Illiberals and Autocrats Unite to Craft a New World Media Order
Authors: Dorsey James M. 
Published: November 2019

Underlying global efforts to counter fake news, psychological warfare and manipulation of public opinion is a far more fundamental battle: the global campaign by civilizationalists, illiberals, autocrats and authoritarians to create a new world media order that would reject freedom of the press and reduce the fourth estate to scribes and propaganda outlets. The effort appears to have no limits. Its methods range from seeking to reshape international standards defining freedom of expression and the media; the launch and/or strengthening of government-controlled global, regional, national and local media in markets around the world; government acquisition of stakes in privately-owned media; advertising in independent media dependent on advertising revenue; funding of think-tanks; demonization; coercion; repression; and even assassination. The effort to create a new media world order is closely linked to attempts to a battle between liberals and non-liberals over concepts of human rights, the roll-out of massive Chinese surveillance systems in China and beyond and a contest between the United States and China for dominance of the future of technology. The stakes in these multiple battles could not be higher. They range from basic human and minority rights to issues of transparency, accountability and privacy, human rights, the role of the fourth estate as an independent check on power, freedom of expression and safeguards for human and physical dignity. The battles are being waged in an environment in which a critical mass of world leaders appears to have an unspoken consensus on the principles of governance that should shape a new world order. Men like Xi Jinping, Vladimir Putin, Recep Tayyip Erdoğan, Victor Orbán, Benjamin Netanyahu, Mohammed bin Salman, Mohammed bin Zayed, Narendra Modi, Rodrigo Duterte, Jair Bolsonaro, Win Myint and Donald J. Trump have all to varying degrees diluted the concepts of human rights and undermined freedom of the press. If anything, it is this tacit understanding among the world’s foremost leaders that in shaping a new world order constitutes the greatest threat to liberal values.
Infallible or Final?: Revisiting the Legitimacy of the International Court of Justice as the “Invisible” International Supreme Court
Authors: Nucup Neil B. 
Published: November 2019

Abstract
With the anarchic multiplication of international courts and tribunals, and the concomitant possibility for jurisdictional and decisional conflicts among them to occur, treating the International Court of Justice as the “invisible” international supreme court seems an attractive solution. After all, it is the principal judicial organ of the United Nations and the only court with universal general jurisdiction. Revisiting this proposal, the article argues that the World Court suffers not only from political (extrinsic) constraints, but also from institutional (intrinsic) limitations, thereby endangering its sociological and normative legitimacy. Nonetheless, this does not mean rectifying them for the purpose of enabling it to discharge its envisioned role as the international supreme court. Rather the problem is not so much improving the World Court, but understanding the merits of maintaining the status quo, that is, a decentralised judiciary.
International Court of Justice: The Role of Consent in the Context of Judicial Propriety Deconstructed in Light of Chagos Archipelago
Authors: Polonskaya Ksenia 
Published: November 2019

Abstract
This article examines the notion of consent as an element of judicial propriety as defined by the International Court of Justice (ICJ) in the context of its advisory function. The article situates the issue of judicial propriety within a broader conversation on the Court’s normative outlooks in international law, and examines the most recent advisory opinion on the Chagos Archipelago to understand how the Court itself views its role in international law. The article concludes that the Court’s advisory opinions do not provide much clarity as to the circumstances in which a lack of consent will become a compelling enough reason to justify a refusal to give an advisory opinion. The Court appears to ritually recite consent as a relevant element in its assessment of judicial propriety, however, it continues to limit such relevance.
(Not) Proving the Public Good: Scientific Evidence and the Margin of Appreciation
Authors: Burke Ciarán , Molitorisová Alexandra 
Published: November 2019

Abstract
The article offers a critical look at the complex relationship between the European Court of Human Rights (ECtHR) and policy-supportive (scientific) evidence. In particular, due to now commonplace, evidence-based policy-making of national governments, the Court is effectively supplemented with various statistics and studies and tasked with reviewing policy measures aiming to improve the public good. This article investigates the ECtHR’s use and interpretation of policy-supportive evidence in the proportionality analysis, and how this affects the margin of appreciation. The recent case of Dubská and Krejzová concerning the ban on home births, which the article explores in detail, is illustrative in this regard. Although the Court appears to review scientific evidence substantively, an increased proliferation of statistics and studies may bring about controversy in relation to legal cases, without having a conclusive impact upon the outcome of a dispute.
Empagliflozin, a sodium glucose co-transporter-2 inhibitor, alleviates atrial remodeling and improves mitochondrial function in high-fat diet/streptozotocin-induced diabetic rats
Authors: Shao Qingmiao , Meng Lei , Lee Sharen , Tse Gary , Gong Mengqi , Zhang Zhiwei , Zhao Jichao , Zhao Yungang , Li Guangping , Liu Tong 
Published: November 2019

Abstract
Background
Diabetes mellitus is an important risk factor for atrial fibrillation (AF) development. Sodium–glucose co-transporter-2 (SGLT-2) inhibitors are used for the treatment of type 2 diabetes mellitus (T2DM). Their cardioprotective effects have been reported but whether they prevent AF in T2DM patients are less well-explored. We tested the hypothesis that the SGLT-2 inhibitor, empagliflozin, can prevent atrial remodeling in a diabetic rat model.

Methods
High-fat diet and low-dose streptozotocin (STZ) treatment were used to induce T2DM. A total of 96 rats were randomized into the following four groups: (i) control (ii) T2DM, (iii) low-dose empagliflozin (10 mg/kg/day)/T2DM; and (iv) high-dose empagliflozin (30 mg/kg/day)/T2DM by the intragastric route for 8 weeks.

Results
Compared with the control group, left atrial diameter, interstitial fibrosis and the incidence of AF inducibility were significantly increased in the DM group. Moreover, atrial mitochondrial respiratory function, mitochondrial membrane potential, and mitochondrial biogenesis were impaired. Empagliflozin treatment significantly prevented the development of these abnormalities in DM rats, likely via the peroxisome proliferator-activated receptor-c coactivator 1α (PGC-1α)/nuclear respiratory factor-1 (NRF-1)/mitochondrial transcription factor A (Tfam) signaling pathway.

Conclusions
Empagliflozin can ameliorate atrial structural and electrical remodeling as well as improve mitochondrial function and mitochondrial biogenesis in T2DM, hence may be potentially used in the prevention of T2DM-related atrial fibrillation.
The effects of daily meteorological perturbation on pregnancy outcome: follow-up of a cohort of young women undergoing IVF treatment
Authors: Zhao Mingpeng , Zhang Haoyang , Waters Tarah H. B. , Chung Jacqueline Pui Wah , Li Tin Chiu , Chan David Yiu Leung 
Published: November 2019

Abstract
Background
Human reproduction follows a seasonal pattern with respect to spontaneous conception, a phenomenon wherein the effect of meteorological fluctuations might not be unique. However, the effect of seasonal variations on patients who underwent in vitro fertilization (IVF) treatment is unclear. We aimed to evaluate the effects of meteorological variation on the pregnancy rate in a cohort undergoing IVF treatment by performing multivariable analyses.

Methods
We conducted a cohort study in a sub-tropical region with prominent seasonal variations (2005–2016). Women aged < 35 years who were treated with a long ovarian stimulation protocol and underwent fresh embryo transfer (ER) were included. Data on gonadotropin administration (CYCL), oocyte retrieval (OR), ER, and pregnancy outcomes were prospectively recorded. For each patient, the daily average of meteorological data (temperature, humidity, sunlight duration, solar radiation) was recorded from the date of CYCL to ER. Multiple logistic regression analysis adjusted for age, fertilization method, year of the cycle, gonadotropin dose, and transferred embryo grade was performed to determine the relationship between the meteorological parameters and clinical pregnancy. Patients with one successful cycle and one failed cycle were subtracted for a case-control subgroup analysis through mixed effect logistics regressions. Time-series analysis of data in the epidemic level was conducted using the distributed lag linear and non-linear models (DLNMs).

Results
There were 1029 fresh cycles in 860 women (mean age 31.9 ± 2.0 years). Higher mean temperature from CYCL to OR (adjusted odds ratio [aOR] 1.04; 95% confidence interval [CI] 1.01–1.07, P = 0.01) increased the odds of pregnancy, while OR to ER did not show any statistical significance. Compared to that in winter, the odds of becoming pregnant were higher during higher temperature seasons, summer and autumn (aOR 1.47, 95%CI 0.97–2.23, P = 0.07 (marginally significant) and aOR 1.73, 95%CI 1.12–2.68, P = 0.02, respectively). Humidity, sunlight duration, and solar radiation had no effect on the outcome. The subgroup analysis confirmed this finding. The time-series analysis revealed a positive association between temperature and relative risk for pregnancy.

Conclusions
In IVF treatment, the ambient temperature variation alters the pregnancy rates; this aspect must be considered when obtaining patient consent for assisted conception.