bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of p53-R249S on the Suppression of Hepatocellular Carcinoma Cells Survival Induced by Podophyllum Derivatives
Authors: Chen Huan , Zhang Mingyang , Wang Ziping , Li Lingqi , Li Qiqi , Wang Huai 
Published: February 2020

Background:
Hepatocellular Carcinoma (HCC), the second leading cause of cancer-related mortality
with over half a million new cases diagnosed annually in the world, accounts for nearly 70% of cancer deaths in
parts of Asia and Africa. Podophyllum, one of the important members of the lignane class of natural products
derived from plants in Podophyllum peltatum L., has been shown to suppress tumor growth in various cancers.
However, the effects of Podophyllum compounds on HCC and the mechanisms for its tumor-suppressive function
remain unknown.

Methods:
A molecular docking study was employed to the analysis of the interaction between compounds and
their targeted proteins. Cell proliferation was measured by MTT assay. Western blot analysis was used to evaluate
protein expression. qRT-PCR was performed to assess RNA expression.

Results:
Molecular docking analysis was consistent with the beneficial effect of fluorine atom substituent in the
3-position of 2-aminopyridine in our previous study. Also, P-3F and D-3F displayed the most potent cytotoxicities
against PLC/PRF/5 with p53-R249S and weakest inhibition of L02 (normal liver cell) growth. However,
these derivatives had no effect on the suppression of HepG2 (wild-type p53) and Hep3B (p53-null) proliferation
significantly. Further study showed that both compounds increase γ-H2AX expression in PLC/PRF/5 cell, along
with repression of the c-Myc activation, purportedly by induction of p53 level and transcriptional activation.

Conclusion:
The results suggested that podophyllum derivatives containing fluorine atom in the 3-position of 2-
aminopyridine could inhibit the growth of HCC harboring p53-R249S by restoring the activity of p53 with decreasing
the level of c-Myc.
Factors Affecting Sustainability Performance during the Construction Stage in Building Projects-Consultants’ Perspective
Authors: Tayeh Bassam A. , Abu Aisheh Yazan I. , Abuzuhri Ibrahim O. 
Published: February 2020

Background:
The construction industry significantly contributes towards enriching human inhabitation within the built environment. However, the industry generates one-third of the world’s carbon emissions per annum (a major contributor to climate change). In response, a sustainable construction development agenda has been propagated by governments worldwide.

Objective:
This research investigates the factors affecting sustainability performance during the construction stage of building projects in the Gaza Strip from consultants’ viewpoint.

Methods:
A questionnaire was distributed to 35 consultants, and 31 completed questionnaires were returned, representing a response rate of 88.57%. A total of 55 variables were considered in this study and listed within three thematic factor groups, namely, economic, social and environmental factors. Data collected were analysed using factor analysis and relative important index within the Statistical Package for the Social Sciences (v22).

Results:
Results indicated that the most influential factors are i) Economic: professional fees of engineers and consultants, energy cost and use of full equipment capacity; ii) Social: availability of knowledge and skills in the labour force, increased burden on infrastructure as a result of the use and depletion of natural resources and public awareness; and iii) Environmental: environmental regulations, pollution generation and waste generation.

Conclusion:
Lack of awareness about economic and social sustainability was found due to the traditional definition of environmental
sustainability and the upper and indirect super-vision of consultants to the construction stage.
Content Analysis of Apps for Growth Monitoring and Growth Hormone Treatment: Systematic Search in the Android App Store
Authors: Fernandez-Luque Luis , Labarta José I , Palmer Ella , Koledova Ekaterina 
Published: February 2020

Background
The use of mobile apps for health is growing. This rapid growth in the number of health apps can make it hard to assess their quality and features. The increased demand for and availability of mobile health apps highlights the importance of regular publication of reviews to identify potential areas of unmet needs and concern. The focus of this review is mobile apps for monitoring growth for health care professionals, caregivers, and patients. Monitoring growth as a part of healthy physical development is important across different periods of childhood and adolescence.

Objective
The goal of this content analysis is to map and understand the types of apps that currently exist that are related to growth monitoring and growth hormone treatment.

Methods
A semiautomated search was undertaken using the app search engine 42Matters, complemented by a manual search for growth apps using the web search tool of Google Play (Android App Store). Apps were rated on their relevance to growth monitoring and categorized by independent raters.

Results
In total, 76 apps were rated relevant to growth monitoring or growth hormone treatment. The level of agreement was measured for the semiautomated search and was very high (Κ=0.97). The target audience for 87% of the apps (66/76) was patients and relatives, followed by health care professionals (11%; 8/76) and both (3%; 2/76). Apps in the category “growth tracking tools for children and babies” were retrieved most often (46%; 35/76) followed by “general baby care apps” (32%; 24/76), “nonpharmacological solutions for growth” (12%; 9/76) and “growth hormone–related” (11%; 8/76). Overall, 19/76 apps (25%) tracked a precise location.

Conclusions
This study mapped the type of apps currently available for growth monitoring or growth hormone treatment that can be used as a foundation for more detailed evaluations of app quality. The popularity of care apps for children and growth monitoring apps should provide a great channel for potential intervention in childhood health in the future.
Text Message Behavioral Intervention for Teens on Eating, Physical Activity and Social Wellbeing (TEXTBITES): Protocol for a Randomized Controlled Trial
Authors: Partridge Stephanie R , Raeside Rebecca , Singleton Anna C , Hyun Karice , Latham Zoe , Grunseit Alicia , Steinbeck Katharine , Chow Clara , Redfern Julie 
Published: February 2020

Background
Obesity is among the most significant health challenges facing today’s adolescents. Weight gain during adolescence is related to cardiovascular disease, type 2 diabetes, and some cancers in later life. Presently, adolescents living in Australia have limited access to age-appropriate obesity prevention services.

Objective
This study aims to investigate whether a two-way text message program, with optional telephone health counseling, improves body mass index (BMI) z score and lifestyle outcomes in adolescents who are overweight.

Methods
This study will be a single-blind randomized controlled trial (N=150) comparing a two-way text message intervention, with optional telephone health counseling, to usual care in adolescents (13-18 years old, inclusive) who are overweight (recruited from a pediatric weight management clinic and the broader community in Sydney, Australia). The intervention group will receive a six-month text message program, which consists of two-way, semipersonalized, lifestyle-focused text messages (four messages/week) in addition to usual care. The control group will be assigned to receive usual care. The study also includes a follow-up at 12-months. The primary outcome is a change in BMI z score at six months. Secondary outcomes are changes in waist-to-height ratio, diet, physical and sedentary activity levels, sleep quality, quality of life, self-esteem, self-efficacy, social support, and eating disorder and depression symptoms. Also, we will examine acceptability, utility, and engagement with the program through a study-specific process evaluation questionnaire, semi-structured telephone interviews, and an analysis of health counselor communication logs. The analyses will be performed by the intention-to-treat principle to assess differences between intervention and control groups.

Results
The study opened for recruitment in December 2019. Data collection is expected to be completed by December 2021, and the results for the primary outcome are expected to be published in early 2022.

Conclusions
This study will test the effectiveness of an interactive two-way text message program compared to usual care in improving BMI z score and lifestyle outcomes in adolescents with overweight. This interactive, innovative, and scalable project also aims to inform future practice and community initiatives to promote obesity prevention behaviors for adolescents.

Trial Registration
Australia New Zealand Clinical Trials Registry (ANZCTR) ACTRN12619000389101; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=377158&amp;isReview=true

International Registered Report Identifier (IRRID)
DERR1-10.2196/16481
Effectiveness of Electronic Health Interventions in Improving Treatment Adherence for Adults With Obstructive Sleep Apnea: Meta-Analytic Review
Authors: Aardoom Jiska Joëlle , Loheide-Niesmann Lisa , Ossebaard Hans C , Riper Heleen 
Published: February 2020

Background
Poor adherence to continuous positive airway pressure (CPAP) treatment by adults with obstructive sleep apnea (OSA) is a common issue. Strategies delivered by means of information and communication technologies (ie, electronic health [eHealth]) can address treatment adherence through patient education, real-time monitoring of apnea symptoms and CPAP adherence in daily life, self-management, and early identification and subsequent intervention when device or treatment problems arise. However, the effectiveness of available eHealth technologies in improving CPAP adherence has not yet been systematically studied.

Objective
This meta-analytic review was designed to investigate the effectiveness of a broad range of eHealth interventions in improving CPAP treatment adherence.

Methods
We conducted a systematic literature search of the databases of Cochrane Library, PsycINFO, PubMed, and Embase to identify relevant randomized controlled trials in adult OSA populations. The risk of bias in included studies was examined using seven items of the Cochrane Collaboration risk-of-bias tool. The meta-analysis was conducted with comprehensive meta-analysis software that computed differences in mean postintervention adherence (MD), which was defined as the average number of nightly hours of CPAP use.

Results
The meta-analysis ultimately included 18 studies (N=5429 adults with OSA) comprising 22 comparisons between experimental and control conditions. Postintervention data were assessed at 1 to 6 months after baseline, depending on the length of the experimental intervention. eHealth interventions increased the average nightly use of CPAP in hours as compared with care as usual (MD=0.54, 95% CI 0.29-0.79). Subgroup analyses did not reveal significant differences in effects between studies that used eHealth as an add-on or as a replacement to care as usual (P=.95), between studies that assessed stand-alone eHealth and blended strategies combining eHealth with face-to-face care (P=.23), or between studies of fully automated interventions and guided eHealth interventions (P=.83). Evidence for the long-term follow-up effectiveness of eHealth adherence interventions remains undecided owing to a scarcity of available studies and their mixed results.

Conclusions
eHealth interventions for adults with OSA can improve adherence to CPAP in the initial months after the start of treatment, increasing the mean nightly duration of use by about half an hour. Uncertainty still exists regarding the timing, duration, intensity, and specific types of eHealth interventions that could be most effectively implemented by health care providers.
Pengaruh intensi, pengalaman menggunakan internet, kondisi pemfasilitasan, dan undang undang informasi & transaksi elektronik No. 11/2008 terhadap cybercrime
Authors: Anwar Achmad Syaiful Hidayat 
Published: February 2020

The aims of this research is to test the influence of intension, experience using the internet, facilitating conditions and undang-undang Informasi & Transaksi Elektronik (ITE) No. 11/2008 on cybercrime. This research uses survey methods. Cluster sampling and purposive sampling method are used to determine research sample. The respondents are internet users who use the internet at warnet and are located in Yogya- karta, Surabaya and Malang. Some 300 questionnaires have been distributed and received back. A total of 291 questionnaires revealed to be analyzed by using multiple regression analysis. Based on the analysis results can be concluded that intention, experience using the Internet, facilitating conditions and UU ITE No. 11/2008 positively influence the occurrence of cybercrime. For further research, it is advisable to increase research variables also affect the occurrence of cybercrime, among others, and increase the number of samples. It aims to obtain research results more representative so that results can be generalized. Keywords: cybercrime, internet, UU ITE No. 11/2008
Panduan bagi Penulis
Authors: Jurnal Admin 
Published: February 2020

A. Jenis Kontribusi 1. JRAK memublikasikan tulisan dalam bentuk artikel konseptual (conceptual paper) dan/atau artikel hasil penelitian (research paper) yang termasuk dalam bidang ilmu Akuntansi dan Keuangan. Objek kajian tulisan dapat meliputi tema-tema tentang kewirausahaan, sektor publik, keuangan syari’ah, knowledge management, dan intellectual capital.2. Naskah belum pernah dipublikasikan dan/atau tidak sedang didaftarkan untuk dipublikan pada publikasi lain.3. Semua naskah akan direview oleh dua orang mitra bestari dengan standar penilaian yang telah ditentukan.4. Ketika naskah dinyatakan diterima, maka penulis diminta untuk mengirim surat pernyataan keaslian/non-plagiarism. B. Ketentuan Umum 1. Naskah ditulis dalam bahasa Indonesia atau bahasa Inggris2. Naskah ditulis dengan program MS. Word dan disimpan dalam format “word for windows” dalam satu kolom dengan spasi ganda (double space).3. Seluruh halaman dalam naskah harus diberi nomor halaman di bagian bawah kanan, dimulai dari nomor 1. Ukuran kertas yang digunakan adalah A4 dengan margin 3.0 cm untuk semua sisi.4. Jenis font yang digunakan adalah “Times New Roman” 12pt.5. Panjang naskah tidak lebih dari 16-18 halaman, dan tidak diperkenankan mencantumkan lampiran.6. Semua tabel dan gambar diketik dalam halaman yang sama dalam naskah dan diberi nomor sesuai urutan kemunculannya serta diberi judul yang sesuai.7. Penggunaan istilah asing harus mengacu pada standar yang telah ditetapkan (gunakan GLOSARIUM). 8. Naskah dikirim lewat email (dalam bentuk attachment file) dan/atau lewat pos (dalam bentuk CD dan hard copy). C. Struktur Naskah Secara umum, naskah harus disusun dalam urutan sebagai berikut: Judul; Abstract; Pendahuluan; Metode; Hasil dan Pembahasan; Simpulan; ucapan terima kasih (pilihan); dan Daftar Pustaka. Sub judul harus ditulis dengan huruf besar dan tebal (bold capital) dan diletakkan di tengah-tengah halaman.
MANAGEMENT CAPABILITY TO PRODUCE QUALITY EARNING
Authors: Edi Edi , Yopie Santi 
Published: February 2020

This research aims at analyze the effects of management ability to earning quality that is measured by restatement, earning persistence, and accrual quality. The objective of this research is to examine how far the capabilities of firm’s management can make earning for the firm to become more qualified The research populations were taking from the non-financial reports of companies listed in Indonesia Stock Exchange in the period 2008 until 2016. The sample used for this research are 248 firm or 1.240 observation data which was using purposive sampling method. This research uses panel regression method to analyze the effect of independent variables on the dependent variable. The observation data are analyzed and processed using Statistical Package for the Social Sciences (SPSS) and Eviews 7th version. The result indicates that management ability, independent directors and the total number of directors significant to earning quality that is measured by earning restatement, earning persistence and accrual quality in Indonesia Stock Exchange.
ANALISIS PERBEDAAN PERSEPSI BUSINESS BRAND LINTAS GENERASI PADA ANGKATAN VIII “FAMILY BUSINESS UNIVERSITAS CIPUTRA”
Authors: Padmalia Metta 
Published: February 2020

Penelitian bertujuan untuk menganalisis perbedaan persepsi tiga dimensi family business brand (family firm identity, family firm image, dan family firm reputation) antara incumbent-keluarga, incumbent-non-keluarga, dan generasi penerus. Penelitian berikut diharapkan dapat memberikan pemahaman terkait bagaimana tiga subsistem yang berbeda dalam suatu bisnis keluarga memiliki pemahaman terhadap family business brand. Apabila terdapat peredaan persepsi maka akan diusulkan strategi yang tepat agar operasional perusahaan dapat lancer dan terjadi peningkatan nilai merek perusahaan tersebut. Populasi dalam penelitian ini adalah seluruh pemilik bisnis keluarga dari kelompok Family Business Universitas Ciputra angkatan VIII, penentuan sampel dilakukan berdasarkan purposive random sampling dengan kriteria tertentu.Metode penelitian yang digunakan adalah uji beda nyata One Way ANOVA yang dioperasikan menggunakan program IBM SPSS Statistics 23. Hasil analisis menunjukkan bahwa terdapat perbedaan yang signifikan di antara ketiga kategori responden pada dimensi family firm identity dan family firm reputation. Sedangkan pada family firm image tidak terdapat perbedaan yang signifikan di antara ketiga kategori responden.
EFEKTIFITAS FREE FLOAT DALAM MENDONGKRAK LIKUIDITAS BURSA EFEK INDONESIA
Authors: Fitriani Deuis , Iqbal Syaiful , Andayani Wuryan 
Published: February 2020

This study aims to investigate the effect of free float toward market liquidity of Indonesia Stock Exchange, as effectiveness evidence in the implementation of regulation Number: Kep-0001/BEI/01-2014. This study involves a number of control variables consist of stock price, firm size, stock return, price to book value, earnings per share, and price to earnings ratio. They have determined the market liquidity simultanuosly. An analysis was carried out on the archival data sourced from idx.co.id which covering manufacturer companies that have been recorded in the period of 2014-2018. The result shows that free float has a positive influence to the liquidity of the Indonesia Stock Exchange (BEI). Free float’s contribution has been occured together with all of the control variables. This result confirms that information about free float is one thing that is taken into consideration in deciding capital market investment, and becomes empirical evidence of the effectiveness of the stated regulation above. Penelitian ini bertujuan untuk menginvestigasi pengaruh free float terhadap likuiditas pasar di Bursa Efek Indonesia, sebagai bukti efektifitas regulasi/peraturan Nomor: Kep-0001/BEI/01-2014. Penelitian ini melibatkan sejumlah variabel kendali yang secara bersama-sama menentukan likuiditas pasar, yaitu stock price, firm size, stock return, price to book value, earning per share, dan price to earnings ratio. Analisis dilakukan terhadap data arsif yang bersumber dari idx.co.id meliputi perusahaan manufaktur yang tercatat pada periode 2014-2018. Hasil penelitian menunjukkan bahwa free float mempunyai pengaruh positif terhadap likuiditas pasar Bursa Efek Indonesia (BEI). Kontribusi free float terjadi secara bersama-sama dengan seluruh variabel kendali. Hasil ini menegaskan bahwa informasi tentang free float merupakan satu hal yang menjadi pertimbangan dalam keputusan investasi pasar modal, dan sekaligus menjadi bukti empiris efektifitas regulasi tersebut di atas.
NATURALISME-TEISTIK ABU BAKAR ALRAZI
Authors: Isfaroh Isfaroh 
Published: February 2020

This study aims to look at the construction of Abu Bakar Alrazi's theological theistic naturalism.This study used the historical approach of biographical reconstruction, to understand and explore one's personality by looking at his socio-cultural and intellectual background. This study found, first, as a scientist Alrazi used theistic reasoning of naturalism because of the socio-religious conditions in its time experienced truth manipulation and limited potential, religious communities were prohibited for rational speculation on religion, because they were considered sacred and established. According to Alrazi, this is the reason why the truth becomes silent and its nature is very closed. Second, Razi is a pure rationalism, makes reason as proof of God's existence, because through reason he can think about the problems of life.This study contributes to the development of new thoughts on scientific and Islamic discourse in Indonesia, particularly in the field of Islamic philosophy.
The Consequences of Accounting Failure for Innovation: A Multi-Level Analysis
Authors: Hess Megan F. , Hess Andrew M. 
Published: February 2020

SYNOPSIS
In this study, we investigate the relation between accounting failure and innovation at multiple levels in an organization by developing and testing a model for how top executives and functional managers might change their risk preferences and their innovation investments in response to public disclosures of financial misconduct. At the firm level, we find that accounting failures reduce subsequent investments in R&D, as predicted by a threat rigidity (“play it safe”) psychological response among top executives. At the project level, accounting failures have the opposite effect, resulting in an increase in the number of exploratory projects, as predicted by a failure trap (“swing for the fences”) psychological response among functional managers. Unpacking this relation at multiple levels of analysis helps us to understand the complex ways in which financial misconduct shapes a firm's innovation activities and appreciate the far-reaching consequences of accounting failure.
PENERAPAN BENTUK MEDIASI PENAL DENGAN PENDEKATAN KEADILAN RESTORATIF DALAM SISTEM PERADILAN PIDANA ANAK
Authors: Ulfatun Nisa Candra , Putra Jaya Nyoman Serikat 
Published: February 2020

Sistem peradilan pidana anakwajib menggunakan pendekatan keadilan restoratif dengan melalui diversi. Diversi dalam penyelesaian perkara anak adalah proses peradilan pidana yang dialihkan ke proses di luar peradilan pidana. Jurnal ini difokuskan pada bentuk penerapan mediasi penal sekaligus pembatasan pemberlakuannya dalam sistem peradilan pidana anak yang diatur dalam Undang-Undang Nomor 11 Tahun 2012 Tentang Sistem Peradilan Pidana Anak. Metode pendekatan yang digunakan adalah yuridis normatif, dengan spesifikasi penelitian deskriptif. Hasil penelitian ini adalahbahwa sistem peradilan pidana anak mengandung pengertian bentuk mediasi penal, dengan dua pendekatan yakni victim offender mediationdan restorative conferencing yangmeliputi family group conference.Kata Kunci:mediasi penal, keadilan restoratif, diversi.