bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reorientasi Pendidikan Pesantren (Telaah Atas Tujuan Pendidikan Islam Di Pondok Pesantren Al-Islam Joresan Mlarak Ponorogo)
Authors: Arkam Rohmad 
Published: February 2020

In the middle current education system competition, pesantren as institute of eldest education that stills to withstand up to now indeed has to be realised that pesantren's orientation that at only region keagamaan( tafaqquh fi al at n ) no longer is equal to. Therefore pesantren shall proactive and give room for fix and education system update pesantren, so collegiate pesantren can become of change's agent in the middle mansyarakat is productive, egaliter, and openended to social changed reality, without trasedentalnya's point loss. This research included descriptive research, study is case at pesantren Al's cabin Joresan Mlarak Ponorogo's Islam. In data collecting, writer utilizes to methodic interview, observation, and documentation as tech as its data collecting. tech that is chosen in analisis data is data reduction, data display and conclusion or verification take. Of research result is found, that (1 ) rorientasi's Backgrounds Islam education that done by pesantren Al's cabin Islam, menunjukan that pesantren Al's cabin Islam unawaring to challenge of social change, involve self in social change and makes her as center as that social change alone (2 ) education developmental Aims Islamic at pesantren Al's cabin Islam Joresan Mlarak Ponorogo is correspond to new modernist Model which is method which get effort to understand mendasar's teaching and point that consists in al Qur ’ an and al Sunnah al Shahihah with mengikut attaches and regard classic moslem intellectual treasury (3 ) reorientation Form at pesantren Al's cabin Islam is developmental curriculum, development evaluates and institute.
Pendidikan Karakter Berbasis Local Wisdom (studi kasus di TK Islam PAS Munqidzatun Nasyi’ah Desa Wilangan Kecamatan Sambit Kabupaten Ponorogo)
Authors: Fatoni Tamrin 
Published: February 2020

Developing powerful communications technology has created unlimited free communication. The negative impact of this phenomenon is when a culture that is not good from the outside is swallowed out by children who are still young. As a result, it will easily experience cultural dislocation. One of the legacies of local wisdom that are not interested in the midst of the community is the Javanese dolanan song. Therefore all efforts must be sought from the very beginning. These efforts can be done through various ways, including habituation of children to play and sing songs (songs) dolanan Javanese, which actually contains a lot of character values.
This study included a descriptive study, a case study at PAS Munqidzatun Nasyi'ah Wilangan Islamic Kindergarten. This study aims to describe; 1. Describe the form of character education in PAS Munqidzatun Nasyi'ah Wilangan Islamic Kindergarten. 2. Describe the strategy for implementing character education in PAS Munqidzatun Nasyi'ah Wilangan Islamic Kindergarten. 3. Describe the results of character education in PAS Munqidzatun Nasyi'ah Wilangan Islamic Kindergarten. This research includes field research using a qualitative approach. In collecting data, the author uses the method of interviews, observation, and documentation as a data collection technique. The technique chosen in data analysis is data reduction, data display and conclusions or verification.
From this study it can be seen that: 1. the form of character education in PAS Islamic Kindergarten Munqidzatun Nasyi'ah Wilangan is a local widom-based character education (local wisdom) in the form of Javanese dolanan songs. There are three dolanan songs used for character planting, namely Sluku-sluku Bathok, gundul-gundul Pachol and Menthok-menthok. 2. The strategy for the implementation of character education in PAS Islamic Kindergarten Munqidzatun Nasyi'ah Wilangan is to use reflective methods. This can be proven by giving an explanation of moral values ​​to students, after the song is finished the song is sung both in class before the core lesson begins or while playing outside the classroom. 3. The results of character education at PAS Islam Munqidzatun Nasyi'ah Wilangan Kindergarten have fulfilled the values ​​of the basic characters, namely: a. Respectful and polite character through greeting each other and shaking hands. b. This character of independence and responsibility can be seen from throwing garbage in its place.
INOVASI KURIKULUM: STUDI KASUS DI MADRASAH ALIYAH AL-ISLAM JORESAN MLARAK PONOROGO
Authors: Sholihah Abdah Munfaridatus 
Published: February 2020

The curriculum is one component that is crucial in an education system, because the curriculum is a tool to achieve educational goals and at the same time as a guide in the implementation of teaching at all types and levels of education. Thus the curriculum is always dynamic in order to better adapt to various developments that occur. Every educator must understand the development of the curriculum, because it is the most important pedagogical formulation in the educational context, and the curriculum will illustrate how the work done helps students develop their potential in the form of physical, intellectual, emotional, and social, religious.
To uncover the curriculum innovations carried out at MA Al-Islam Joresan Mlarak Ponorogo, the author will examine how the curriculum innovations implemented at MA Al-Islam Joresan before and after the implementation of the full day school program and how the impact of curriculum innovation on educational outcomes and student self-development at MA Al-Islam Joresan? And researchers apply the type of qualitative research methods, and data collection techniques include in-depth interviews, observation and documentation. Then the data analysis technique used in this study uses the concept given by Miles & Huberman. From the results of the study it was found that the curriculum innovation at Joresan Aliyah Al-Islam Madrasah was carried out in two stages, the first was curriculum innovation before the implementation of the full day school classroom program. The first phase was implemented in 1984, while the second innovation was carried out in 2010 by implementing a full day class program. The impact of curriculum innovation in Madrasah Aliyah Al-Islam Joresan is very influential on student learning outcomes and self-development of full day class students.
Математична модель скручування валу трансмісії повнопривідних тягово-транспортних засобів при русі з блокованим приводом
Authors: Потапов М. , Молодан А. , Полянський О. 
Published: February 2020

Стаття присвячена проблемі скручування вала трансмісії автомобілів, що мають блокований привід переднього і заднього (задніх ведучих мостів, відбувається перерозподіл через трансмісію гальмівних моментів між колесами відповідно до припадає на них нормальним навантаженням і коефіцієнтом зчеплення з дорогою. Зазначене явище супроводжується додатковою завантаженістю елементів ходової частини, їх зносом і, як наслідок, додатковими втратами потужності двигуна і витратою палива. Крім того, при русі тягово-транспортних засобів (ТТС) по криволінійній траєкторії кінематична невідповідність обумовлюється ще й тим, що його осі повинні одночасно проходити різні шляхи, тоді як, будучи з блокованими, вони прагнуть рухатися з однаковими поступальними швидкостями.
Отримано вираз, що показує характер розвитку коливань в трансмісії повнопривідного ТТС. Знайдено рішення отриманого рівняння з урахуванням початкових і граничних умов параметрів трансмісії і коліс. Отримано графік зміни енергії крутильних коливань в трансмісії автомобіля при максимально можливій різниці радіусів коліс. Обчислена енергія коливань при різних законах зміни моменту опору руху ТТС.
Доведено, що зміна закону моменту опору руху не впливає на коливання трансмісії. Розрахунки на моделі показали, що при зміні радіусів коліс в 30 разів і більше призводить до помітних коливань у трансмісії, що неможливо при експлуатації автомобіля. Отримані теоретичні результати, пов'язані з вивченням динаміки трансмісії, дозволяють зробити висновок про те, що необхідно встановити фактори, що впливають на додаткові втрати палива в автомобілі при його експлуатації в повнопривідному режимі.
Особливості визначення оптимального плану використання флотів БПЛА заданого радіусу дії для моніторингу об’єктів на території атомних станцій
Authors: Фесенко Г. 
Published: February 2020

Запропоновано алгоритм визначення оптимальної сукупності флотів БПЛА угруповання для моніторингу заданих точок на території 30-кілометрової зони Запорізької АЕС для різних критеріїв оптимізації. Показана можливість застосування запропонованого алгоритму для визначення оптимального плану використання угруповання з 6 флотів БПЛА для моніторингу 10 постів контролю автоматизованої системи контролю радіаційної обстановки Запорізької АЕС. Зони спостереження для кожного з флотів БПЛА сформовано відповідно до радіусу їх дії. Показано, що радіус дії кожного флоту визначається з урахуванням часового ресурсу батареї та швидкості БПЛА, відстані між стартовою позицію та постом контролю, а також часу моніторингу. Розглянуто два варіанти комплектування флотів БПЛА. В першому випадку всі флоти укомплектовані БПЛА DJI MAVIC AIR. У другому варіанті комплектування у складі третього флоту використано БПЛА Parrot Bebop-Pro Thermal. У якості критеріїв оптимізації обрано загальну кількість флотів для виконання моніторингу (основний критерій), та сумарний час виконання угрупованням флотів БПЛА моніторингу постів контролю. У якості методу оптимізації використано метод послідовник поступок. Показано, що для запропонованих вихідних даних заміна БПЛА Parrot Bebop-Pro Thermal на БПЛА DJI MAVIC AIR у третьому флоті дозволяє зменшити як кількість залучених для моніторингу флотів (з чотирьох до 2 одиниць), так і сумарний час виконання угрупованням флотів моніторингу (на 33,2 хвилини). Отримані результати доцільно використовувати для обґрунтування складу флотів БПЛА та їх розміщення під час виконання ними завдань щодо моніторингу елементів інфраструктури потенційно небезпечних об’єктів.
SZ Scaling Relations of Galaxy Groups and Clusters Near the North Ecliptic Pole
Authors: Pratt Cameron T. , Bregman Joel N. 
Published: February 2020

Abstract
Sunyaev–Zel’dovich (SZ) scaling relations have been used to test the self-similar prediction for massive galaxy clusters, but little attention has been given to individual galaxy groups. We investigate the scaling relations of galaxy groups and clusters near the North Ecliptic Pole using X-ray and SZ observations. This region of the sky is where both the ROSAT and Planck satellites achieved their deepest observations, permitting the investigation of lower mass systems. Our sample consists of 62 X-ray detected groups and clusters, spanning a mass range of

and redshifts of 0.03 ≲ z ≲ 0.82. We extract the total SZ flux from unresolved Planck data and estimate the fraction of the SZ flux within R
500 assuming two different pressure profiles. The SZ scaling relations were derived using a Bayesian technique that accounts for censored data. We find a power law slope of

for the Y
SZ–M
500 relation that is consistent with the self-similar prediction of 5/3. The slope of

for the

relation is in agreement with other observational studies but not the self-similar prediction of 5/4, and the

relation lies below the 1:1 relation when the slope is fixed to unity. The determined scaling relations are dependent on the selected pressure profile, so resolved data are needed to determine the effects of active galactic nucleus feedback. In addition, we find a number of potential cluster candidates in the Planck Compton maps that were not identified in our X-ray sample.
Analysis of Treatment Option for Synchronous Liver Metastases and Colon Rectal Cancer
Authors: Coco Danilo , Leanza Silvana 
Published: February 2020

Colorectal or bowel cancer is one of the major causes of cancer worldwide. Research has shown that 15 to 20% colorectal cancer patients are also diagnosed with synchronous liver metastases (LM) at presentation and about one third eventually develop liver lesions (Leporrier, Maurel, Chiche, Bara, Segol, and Launoy, 2006; Manfredi, Lepage, Hatem, Coatmeur, Faivre, and Bouvier, 2006). Management of cases with colorectal cancer comorbid with liver metastases is more complex (Schmoll, Van Cutsem, Stein, Valentini, Glimelius, Haustermans et al., 2012; Bismuth, Castaing, and Traynor, 1988). This highlights the need for suggesting the need for effective treatment while optimizing timing during surgical and medical treatment of primary plus metastatic disease. According to Fong, Fortner, Sun, Brennan, and Blumgart, 1999), such patients cases are likely to present with severe cancer biology and thereby less likely to be long-term survivors.
Séquence ERC : comment améliorer l’utilisation des méthodes de dimensionnement de la compensation écologique  ?
Authors: Mechin Agnès , Pioch Sylvain 
Published: February 2020

L’insuffisance des connaissances, d’outils et de méthodologies partagés est identifiée comme l’une des causes de la faiblesse de l’application en France de la séquence «  Eviter, Réduire, Compenser  » (ERC) les impacts négatifs résiduels significatifs causés par les projets d’aménagement, plans ou programmes, sur la nature. Cela concerne notamment les méthodes pour évaluer l’atteinte de l’objectif d’absence de perte nette (MAPN). Cet article traite de la question de l’opérationnalité du point de vue des utilisateurs des méthodes c’est-à-dire, des acteurs des territoires concernés par la mise en application de la séquence ERC. Nous analysons la dimension opérationnelle de ces méthodes en nous appuyant sur un cadre théorique original défini par l’ergonomie. La définition de l’opérationnalité proposée dans ces travaux est basée sur trois composantes qui sont l’utilité, l’utilisabilité et l’acceptabilité socio-organisationnelle. Nous associons à ces trois composantes quinze critères déterminés à partir de la bibliographie de référence et de nos enquêtes auprès des acteurs de terrain. Le premier résultat de ces travaux est de démontrer qu’environ la moitié des critères déterminant une bonne prise en compte de la dimension opérationnelle des MAPN ne sont pas considérés par les concepteurs. À ce stade, elle peut s’avérer utile pour guider la conception, se doter d’un vocabulaire commun et ne pas négliger des points peu pris en compte ou simplement «  oubliés  » jusque-là dans la conception des MAPN en France.
Suppression of lncRNA-MALAT1 activity ameliorates femoral head necrosis by modulating mTOR signaling
Authors: Ma Luyao , Gao Jian 
Published: February 2020

IntroductionAvascular necrosis of the femoral head (ANFH) is one of the most complicated bone disorders; management remains challenging. We evaluated the effect of lncRNA-MALAT1 suppression on ANFH rats.Material and methodsDexamethasone was injected intravenously at 0.5 mg/kg daily for 30 days to induce ANFH; an lncRNA-MALAT1 inhibitor group received the inhibitor for the entire 30 days. LncRNA-MALAT1 suppression was evaluated by measuring blood hexosamine and hydroxyproline levels, and that of circulating endothelial progenitor cells (EPCs). Changes in femoral head bone ultrastructure were assessed via transmission electron microscopy and magnetic resonance imaging (MRI). We used reverse transcription polymerase chain reaction (RT-PCR) and Western blotting to measure gene and protein expression levels in femoral head tissue.ResultsThe blood hexosamine level rose and that of hydroxyproline fell in the LncRNA-MALAT1 inhibitor group compared to the ANFH group. LncRNA-MALAT1 suppression increased the level of circulating EPCs. Ultrastructural changes in the femoral bone head were alleviated by the lncRNA-MALAT1 inhibitor. LncRNA-MALAT1 suppression lowered the levels of AMPK, mTOR, and Beclin-1 in rat tissue homogenates.ConclusionsLncRNA-MALAT1 suppression attenuated dexamethasone-induced femoral head necrosis by regulating AMPK/mTOR/Beclin-1 signaling.
Ginsenoside Rh2 inhibits thyroid cancer cell migration and proliferation via activation of miR-524-5p
Authors: Jiang Shan , Yan Jiqi , Chen Xingsheng , Xie Qingji , Lin Wei , Lin Ting , Li Qinyu 
Published: February 2020

IntroductionThyroid cancer is an important disease that threatens the health of humans. Ginsenoside Rh2 is known as an anticancer molecule; however, its function in thyroid cancer cells has not been reported. In the present study, we identified that Rh2 treatment of the thyroid cancer cell line K1 inhibited cell migration and proliferation.Material and methodsWe determined the Rh2 function in thyroid cancer cell lines. By RT-PCR, expression of miR-524-5p and related genes were determined. The cell phenotype including cell migration and proliferation were detected after serials treatment. The relevant protein level were checked by Western blot.ResultsInterestingly, we observed that miR-524-5p, a type of miRNA, had lower expression in the thyroid cancer cell lines TPC-1, K1, and NPA than in the normal thyroid cell line Nthyri3-1. Additionally, Rh2 treatment induced miR-524-5p expression. Further examination using overexpression of miR-524-5p identified that the miR-524-5p mimic inhibited cell migration and proliferation of the K1 line. Similar to Rh2-treated cells, the miR-524-5p mimic-expressing cells had increased E-cadherin and reduced vimentin levels compared to the control cells. Next, we examined the relationship between Rh2 and miR-524-5p with respect to thyroid cell migration and proliferation. Treatment with Rh2 and miR-524-5p inhibitor suppressed Rh2 action on K1 thyroid cell migration and proliferation, and the rates were similar to those in control cells, suggesting that Rh2 might induce miR-524-5p expression to inhibit thyroid cancer cell migration and proliferation.ConclusionsOur analyses identified Rh2 and miR-524-5p action on thyroid cancer cell migration and proliferation as well as the linkage between Rh2 and miR-524-5p in thyroid cancer cell development.
Mechanisms underlying the improvement of preeclampsia through salvianolic acid B-regulated miRNA-155/CXCR4
Authors: Zhang Chuanlian , Han Xue , Wang Xiaoxue 
Published: February 2020

IntroductionThe aim of this study was to evaluate the effects and mechanisms of salvianolic acid B (Sal B) in preeclampsia treatment by in vivo and in vitro study.Material and methodsRats were randomly divided into 5 groups. In order to establish the model of preeclampsia, endotoxin was administered to the rats in the Sal B intervention and model groups. The systolic blood pressure (SBP) of the tail artery and urine protein concentration were observed at different points, the miRNA-155 and CXCR4 gene expression levels by RT-PCR and the CXCR4 and p-AKT protein expression by WB assay. Using HTR8/SVneo to explain the mechanisms; evaluating the miRNA-155 and CXCR4 mRNA expression by RT-PCR assay, measuring the cell invasion and migration by transwell and wound healing assay in different groups; evaluating the CXCR4 and p-AKT protein expression by WB assay and p-AKT nucleation volume by cellular immunofluorescence were evaluated.ResultsCompared with the normal group, the systolic blood pressure and urine protein were significantly increased in the model group (p < 0.05), serum NO concentration was significantly down-regulated (all p < 0.05), CXCR4 and miRNA-155 mRNA expression was significantly different and CXCR4 and p-AKT protein expression was significantly suppressed (all p < 0.05). With Sal B supplement, the SBP, urine protein and NO concentration were significantly improved with dose-dependent (all p < 0.05). In the cell experiment, the cell invasion and migration ability were significantly improved with Sal B supplement (both p < 0.05). However, with miRNA-155 transfection, the cell invasion and migration ability were suppressed with Sal B treatment (both p < 0.05).ConclusionsSal B improved preeclampsia via regulation of miRNA-155/CXCR4 in the in vitro and vivo study.
Role of Hybrid Operating Room: Present and Future
Authors: Qize Yuan Evan , Sze Hang Ng Calvin 
Published: February 2020

With the dramatic progress of medical imaging modalities and growing needs for high-resolution intraoperative imaging in minimally invasive surgery, hybrid operative room (OR) has been developed as a powerful tool for different surgical scenarios. Under the guidance of high-definition cone beam CT (CBCT), an electromagnetic navigation bronchoscopy (ENB)-based marker implantation and subsequent localization of the pulmonary nodules can be implemented within a hybrid OR. Furthermore, the unparalleled real-time imaging capabilities and the ability to perform multiple tasks within the hybrid OR can facilitate image-guided single-port video-assisted thoracic surgery (iSPVATS), increasing the precision and improving outcomes of the procedure. With the help of a hybrid theatre, catheter-based thermal ablation can provide a safer and less invasive treatment option for select patient groups with early-stage non-small cell lung carcinomas (NSCLC) or metastases. In the future, the combination of hybrid operating room and other inspiring innovative techniques, such as robotic bronchoscopy, 3D-printing, natural orifice transluminal endoscopic surgery (NOTES) lung surgery could lead to a paradigm shift in the way thoracic surgery is conducted.
The detection of trans gene fragments of hEPO in gene doping model mice by Taqman qPCR assay
Authors: Aoki Kai , Sugasawa Takehito , Yanazawa Kouki , Watanabe Koichi , Takemasa Tohru , Takeuchi Yoshinori , Aita Yuichi , Yahagi Naoya , Yoshida Yasuko , Kuji Tomoaki , Sekine Nanami , Takeuchi Kaoru , Ueda Haruna , Kawakami Yasushi , Takekoshi Kazuhiro 
Published: February 2020

Background
With the rapid progress of genetic engineering and gene therapy methods, the World Anti-Doping Agency has raised concerns regarding gene doping, which is prohibited in sports. However, there is no standard method available for detecting transgenes delivered by injection of naked plasmids. Here, we developed a detection method for detecting transgenes delivered by injection of naked plasmids in a mouse model that mimics gene doping.

Methods
Whole blood from the tail tip and one piece of stool were used as pre-samples of injection. Next, a plasmid vector containing the human erythropoietin (hEPO) gene was injected into mice through intravenous (IV), intraperitoneal (IP), or local muscular (IM) injection. At 1, 2, 3, 6, 12, 24, and 48 h after injection, approximately 50 µL whole blood was collected from the tail tip. One piece of stool was collected at 6, 12, 24, and 48 h. From each sample, total DNA was extracted and transgene fragments were analyzed by Taqman quantitative PCR (qPCR) and SYBR green qPCR.

Results
In whole blood DNA samples evaluated by Taqman qPCR, the transgene fragments were detected at all time points in the IP sample and at 1, 2, 3, 6, and 12 h in the IV and IM samples. In the stool-DNA samples, the transgene fragments were detected at 6, 12, 24, and 48 h in the IV and IM samples by Taqman qPCR. In the analysis by SYBR green qPCR, the transgene fragments were detected at some time point in both specimens; however, many non-specific amplicons were detected.

Conclusions
These results indicate that transgene fragments evaluated after each injection method of naked plasmids were detected in whole-blood and stool DNA samples. These findings may facilitate the development of methods for detecting gene doping.