bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human Factors-basierte Arbeitsgestaltung in Cyber-Physischen Produktionssystemen
Authors: Stern Hendrik , Freitag Michael 
Published: June 2020

Kurzfassung
Die Einführung Cyber-Physischer Produktionssysteme (CPPS) verursacht einen Wandel der Arbeit und erfordert daher aktualisierte Gestaltungsregeln für Benutzerschnittstellen innerhalb der Arbeitssysteme. Der vorliegende Beitrag stellt eine Methode zu deren Bestimmung auf Basis von Human Factors-Forschungstechniken vor. Im Rahmen einer Anwendung der Methode wurden Studien durchgeführt, die die Effekte verschiedener Gestaltungsansätze sowohl auf die Arbeitsleistung als auch auf das Arbeitsempfinden quantifizieren und so die Ableitung von Gestaltungsregeln ermöglichen.
Prozessuale Grundtypen für eine hybride Produktentwicklung
Authors: Riesener Michael , Dölle Christian , Ays Johanna , Schuh Günther 
Published: June 2020

Kurzfassung
Produzierende Unternehmen sehen sich gegenwärtig mit volatilen Anforderungen konfrontiert. Eine Möglichkeit, der resultierenden Unsicherheit zu begegnen, ist die Implementierung von iterativen Entwicklungszyklen in der Produktentwicklung. Seit einiger Zeit werden daher insbesondere agile Prozessmodelle in Wissenschaft und Praxis diskutiert. Da die Einführung agiler Modelle nicht für jedes Entwicklungsprojekt gleichermaßen geeignet ist, zeichnet sich ein Trend hin zu hybriden Prozessen ab. Der Beitrag leitet drei prozessuale Grundtypen für eine hybride Produktentwicklung her.
Modulare Ladungsträger für den Kleinteiletransport
Authors: Sliwinski Martin , Raabe Corin Manuel , Braun Philipp , Hinckeldeyn Johannes , Kreutzfeldt Jochen 
Published: June 2020

Kurzfassung
In diesem Beitrag wird ein modulares Ladungsträgerkonzept für den manuellen Kleinteiletransport vorgestellt. Mehrere unabhängig voneinander einsetzbare Module können dabei gekoppelt werden und so einen äußerst flexiblen und individuellen Ladungsträgerverbund bilden. Hierdurch lässt sich die Kapazität dem Transportvolumen anpassen und ein vielfältiges Teilespektrum transportieren. Dies reduziert den Bedarf an Logistikflächen und führt zu schlankeren Prozessen.
Cardboard Engineering 4.0 – IIoT für jedermann?
Authors: Aufleger Max , Schneider Markus 
Published: June 2020

Kurzfassung
Der Beitrag befasst sich mit der Bewältigung der Einstiegshürden in die IIoT durch den Einsatz von kostengünstiger Hardware an einem Beispiel in der taktischen Logistikplanung. Das Ausgangsszenario ist eine Endmontage U-Zelle, in der Sensorik prototypisch verbaut wird, um Daten zur Auswertung für die Logistikplanung zu erheben. Das Ergebnis ist ein Proof-of-Concept für ein erweiterbares IIoT-System, auf dessen Basis industrielle Hardware beschafft werden kann.
Flexibilisierung des Änderungsmanagements
Authors: Sippl Fabian , Haghi Sajedeh , Wagner Sarah , Reinhart Gunther 
Published: June 2020

Kurzfassung
In einer turbulenten Umwelt ist das effiziente und effektive Management von Änderungen, sowohl am Produkt als auch in der Produktion, ein Schlüsselfaktor für den Erfolg produzierender Unternehmen. In der Vergangenheit präsentierten bereits mehrere wissenschaftliche Arbeiten Vorgehen zum strukturierten Umgang mit Änderungen. Die bisherigen Ansätze beschreiben das Vorgehen jedoch oftmals auf hohem Abstraktionsniveau und bieten wenig Potenzial zur änderungsspezifischen Anpassung. Um Unternehmen bei der effizienten und individuellen Anwendung der entwickelten Ansätze zu unterstützen, zielt dieser Beitrag darauf ab, eine praxisnahe Methode zur Flexibilisierung des Änderungsmanagementprozesses zu beschreiben. Dies geschieht mithilfe eines Process-Tailoring-Ansatzes auf Grundlage der Charakterisierung von Änderungen.
Auslegung der Auftragsabwicklungsstrategie
Authors: Heuer Tammo , Tatjana Maier Janine , Seitz Melissa , Schmidt Matthias , Nyhuis Peter 
Published: June 2020

Kurzfassung
Die Wahl der Auftragsabwicklungsstrategie beeinflusst wirtschaftliche und logistische Zielgrößen und hat somit weitreichende Auswirkungen auf die Wettbewerbsfähigkeit von Unternehmen. Bestehende Ansätze zu deren Festlegung erfordern meist ein ausgeprägtes Know-how sowie einen hohen Aufwand. In diesem Beitrag wird daher ein Konzept zur Entwicklung eines Modells zur Entscheidungsunterstützung vorgestellt. Dieses soll dem Anwender aufwandsarm eine nachvollziehbare, quantitative Bewertung der Auftragsabwicklungsstrategie je Produkt bzw. Produktgruppe liefern.
Plasma Neurofilament Light: A Marker of Neurodegeneration in Mild Behavioral Impairment
Authors: Naude James P. , Gill Sascha , Hu Sophie , McGirr Alexander , Forkert Nils D. , Monchi Oury , Stys Peter K. , Smith Eric E. , Ismail Zahinoor ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: June 2020

Background: Assessing neuropsychiatric symptoms (NPS) in older adults is important for determining dementia risk. Mild behavioral impairment (MBI) is an at-risk state for cognitive decline and dementia, characterized by emergent NPS in later life. MBI has significantly higher dementia incidence than late life psychiatric conditions. However, its utility as a proxy for neurodegeneration has not been demonstrated. Plasma neurofilament light (NfL) is a validated biomarker of axonal damage, and has been shown to associate with hallmarks of neurodegeneration. Objective: The purpose of this investigation was to identify associations between NfL rate of change and the presence of MBI symptomatology. Methods: We evaluated the association of MBI with changes in NfL in a cohort ( n = 584; MBI + n = 190, MBI– n = 394) of non-demented participants from the Alzheimer’s Disease Neuroimaging Initiative. MBI was determined by transforming Neuropsychiatric Inventory Questionnaire items using a published algorithm. Change in NfL was calculated over 2 years. Results: Time*MBI status was the only significant interaction to predict change in NfL concentrations ( F(1,574) = 4.59, p = 0.032), even after controlling for age, mild cognitive impairment, and demographics. Analyses reclassifying 64 participants with new onset MBI over 2 years similarly demonstrated greater increases in NfL ( F(1,574) = 5.82, p = 0.016). Conclusion: These findings suggest MBI is a clinical proxy of early phase neurodegeneration with putative utility in identifying those at dementia risk. MBI can be used as a case ascertainment approach to capture those at high risk for cognitive decline and dementia, and is an important construct for clinicians dealing with cognitive and neuropsychiatric symptomatology in older adults.
Gait Disturbances are Associated with Increased Cognitive Impairment and Cerebrospinal Fluid Tau Levels in a Memory Clinic Cohort
Authors: Muurling Marijn , Rhodius-Meester Hanneke F.M. , Pärkkä Juha , van Gils Mark , Frederiksen Kristian S. , Bruun Marie , Hasselbalch Steen G. , Soininen Hilkka , Herukka Sanna-Kaisa , Hallikainen Merja , Teunissen Charlotte E. , Visser Pieter Jelle , Scheltens Philip , van der Flier Wiesje M. , Mattila Jussi , Lötjönen Jyrki , de Boer Casper 
Published: June 2020

Background: Gait analysis with accelerometers is a relatively inexpensive and easy to use method to potentially support clinical diagnoses of Alzheimer’s disease and other dementias. It is not clear, however, which gait features are most informative and how these measures relate to Alzheimer’s disease pathology. Objective: In this study, we tested if calculated features of gait 1) differ between cognitively normal subjects (CN), mild cognitive impairment (MCI) patients, and dementia patients, 2) are correlated with cerebrospinal fluid (CSF) biomarkers related to Alzheimer’s disease, and 3) predict cognitive decline. Methods: Gait was measured using tri-axial accelerometers attached to the fifth lumbar vertebra (L5) in 58 CN, 58 MCI, and 26 dementia participants, while performing a walk and dual task. Ten gait features were calculated from the vertical L5 accelerations, following principal component analysis clustered in four domains, namely pace, rhythm, time variability, and length variability. Cognitive decline over time was measured using MMSE, and CSF biomarkers were available in a sub-group. Results: Linear mixed models showed that dementia patients had lower pace scores than MCI patients and CN subjects ( p < 0.05). In addition, we found associations between the rhythm domain and CSF-tau, especially in the dual task. Gait was not associated with CSF Aβ42 levels and cognitive decline over time as measured with the MMSE. Conclusion: These findings suggest that gait — particularly measures related to pace and rhythm — are altered in dementia and have a direct link with measures of neurodegeneration.
Numerical simulation of three dimensional flow in Yazidang Reservoir based on image processing
Authors: Huang Lingxiao , Qiao Qiao , Zheng Lanxiang , Liu Libo , Zhao Wenjuan , Jing Hefang , Li Chunguang 
Published: June 2020

In order to study the water flow movement of the Yazidang Reservoir, this paper generates the initial terrain for the researched water area with the image stitching technology and image edge detection technology, establishes a 3D k - ɛ mathematical model, solves the equations discretely by FVM and SIMPLEC algorithms, studies the numerical simulation of the water flow movement of the reservoir under four working conditions, and analyzes the flow field on the surface and at the bottom of the reservoir. The results show the improved terrain pre-processing accuracy and efficiency of the researched water area and the rationality of the water flow field and rate simulation results, which means that the established 3D turbulence mathematical model can be applied to the numerical simulation of the reservoirs similar to the Yazidang Reservoir. The numerical simulation of 3D turbulence in Yazidang Reservoir provides a theoretical basis and practical application value for the numerical simulation of similar reservoirs.
La importancia de la inversión de riesgo corporativo para superar el valle de la muerte en la transferencia tecnológica universitaria
Authors: Alunni Andrea 
Published: June 2020

Actualmente en un ecosistema clásico de innovación, las oficinas de transferencia tecnológica (TTOs, por sus siglas en inglés) de la universidad estarían buscando aumentar las inversiones del sector privado (i.e. Corporaciones de los varios sectores industriales tales como el farmacéutico, digital, manufacturero, etc.) para avanzar las actividades de investigación basadas en la propiedad intelectual (PI) hacia el mercado. Del otro lado, las Corporaciones también estarían buscando oportunidades de inversión en nuevas empresas (startups) que coincidan con sus actividades de estrategia corporativa basadas en la innovación. Esto parece ofrecer la combinación perfecta para una colaboración universidad–industria exitosa. Sin embargo, al observar los impulsores que motivan esta relación, es posible distinguir que las universidades y las corporaciones tienen sea diferentes perspectivas sobre temas comunes que afectan su relación. Estas diferencias se hacen evidentes, por ejemplo, cuando a un proyecto universitario de investigación se le agota la subvención del gobierno y el investigador aún no ha alcanzado obtener financiación externa de inversores privados para convertirla en una startup. Sin esta inversión externa, el recorrido de la investigación universitaria hacia el mercado para transformarse en producto o servicio social y económicamente útil, pero que aún no es comercialmente viable, puede detenerse. A esta falta de fondos en el desarrollo de un proyecto se le llama “valle de la muerte” y representa el tema central de la discusión de este capítulo.
Temozolomide in glioblastoma treatment: 15-year clinical experience and analysis of its efficacy
Authors: Glavatskyi O.Ya. , Zemskova O.V. , Khmelnytskyi H.V. , Kardash K.A. , Shuba I.M. , Stuley V.A. 
Published: June 2020

Summary. Aim: To analyze retrospectively the efficacy of temozolomide (TMZ) in various treatment regimens in glioblastoma patients accounting for varying parameters of their treatment. Materials and Methods: 302 glioblastoma patients were treated at the State Institution “Romodanov Institute of Neurosurgery of the National Academy of Medical Sciences of Ukraine” from 2003 through 2017. All the patients were surgically treated. In 205 patients, the surgery was followed by adjuvant radiotherapy (RT) with concomitant TMZ (RT + TMZ group). In 97 patients, the surgery was followed by adjuvant RT only (RT group). Kaplan — Meier survival analysis with log-rank test and Cox proportional hazards regression analysis were used for comparing overall survival (OS) and recurrence-free survival (RFS) depending on the age and gender of the patients, the extent of tumor resection, the chemotherapy intensity and the type of RT. Results: In RT + TMZ group as a whole, OS median was 20.7 months vs 10.8 months in RT group (р < 0.0001). The RFS was 14.8 months vs 7.9 months, correspondingly (р < 0.0001).The survival did not depend on the age, gender or localization of the tumor. On the contrary, the intensity of CTX (the number of TMZ cycles in adjuvant mode), the extent of tumor resection, and the type of RT were among the factors affecting significantly OS and RFS. The improvement in OS and RFS with increasing number of the maintenance TMZ courses was more significant in the patients aged below 60. The use of stereotactic conformal mode for RT provides an advantage in the survival over the conventional RT in RT + TMZ group. Conclusions: The combination of concomitant and adjuvant maintenance CTX with TMZ was the most effective CTX regimen affecting positively OS and RFS.
Inhibition of USP1, a new partner of Bcr-Abl, results in decrease of Bcr-Abl level in K562 cells
Authors: Antonenko S.V. , Telegeev G.D. 
Published: June 2020

Summary. Aim: To analyze interaction of ubiquitin specific peptidase 1 (USP1) with Bcr-Abl and to assess the relation between USP1 functional activity and Bcr-Abl expression in K562 chronic myeloid leukemia cells. Materials and Methods: The interaction between USP1 and Bcr-Abl in K562 cells was analyzed by co-immunoprecipitation, Western blot analysis, and confocal microscopy. Results: A direct interaction between Bcr-Abl oncoprotein and USP1 protein in K562 cells was established by co-immunoprecipitation. Immunofluorescence analysis and confocal microscopy revealed that Bcr-Abl/USP1 protein complex is formed in the cell nucleus. The inhibition of USP1 protein activity by ML323 reduced the level of Bcr-Abl oncoprotein in K562 cells. Conclusions: USP1 protein has been identified as a new protein partner of Bcr-Abl oncoprotein in chronic myeloid leukemia. The relationship between the functional activity of USP1 protein and the level of Bcr-Abl oncoprotein has been demonstrated, suggesting that the targeted inhibition of USP1 activity could be a challenging approach for reducing Bcr-Abl expression.
FACTORS THAT HAVE PROGNOSTIC VALUES IN THE MANAGEMENT OF NASOPHARYNGEAL CARCINOMA PATIENTS
Authors: Kangga Chandra , Utama Denny Satria 
Published: June 2020

Introduction: The survival rate of Nasopharyngeal carcinoma (NPC) patients is influenced by several prognostic factors, Such aspatient factors, tumor factors and therapeutic interventions carried out as well as the quality of care. Tumor factors in the form of spread of local invasion, regional lymphatic involvementand metastasis that is reflected in the TNM stage (Tumor, Nodule and Metastatic) are the most important prognostic factors of NPC.
Objective: To determine the Prognostic factors that effectedsurvival rate of nasopharyngeal carcinoma patients.
Material and methods: Analytic observational studywith particular design of survival analysis. Data was taken from medical records and then performed survival analysis on the studiedfactors. Sample of this studywas all patients who were first diagnosed NPC From January 2013 until December 2013 and meetinclusion and exclusion criteria is52 patients.
Results:From 52 patients in the fifth year, 50% died and 50% survive. Survival was worse in the 30-39 year age group (30.8%), male sex (47.2%), Stage IV (44.4%), T4 size (40%), N1 size (23,1%), Distant metastases (40%), WHO type III (48.5%), chemoradiation (48.9%). In multivariate analysis, it was found that the variables that most influenced the survival of NPC patients based on p <0.05 and based on hazard ratio strength were T-size, N-size categories and Metastasis with 95% CI.
Conclusion: Prognostic factors that affect the survival of NPC patients in RSUP. Dr. Mohammad Hoesin Palembang is a category of size T, N, and Metastasis.
LA MODERNIDAD DOMÉSTICA EN EL SECTOR NORTE DE LA CIUDAD DE CUENCA: IDENTIFICACIÓN Y DOCUMENTACIÓN, EJEMPLOS, TIPOS Y VARIACIONES
Authors: Minchala-Leon Marco Antonio , Sinchi-Toral Iván Paúl 
Published: June 2020

Se parte de la hipótesis de que la arquitectura doméstica del sector norte de la ciudad de Cuenca, representa un ejemplo de modernidad en el contexto local. Por esta razón, la investigación, en convenio con el Instituto Nacional de Patrimonio Cultural (INPC), se centró en descubrir este grado de modernidad, desde un muestreo de 11 manzanas que sintetiza la serie de planes de ordenamiento del sector norte en Cuenca. La metodología fue el análisis visual y fotográfico, con el que se identificaron y valoraron 33 viviendas, según los atributos modernos de equilibrio, equivalencia y clasificación; de cuyas variaciones se identificaron tres tipos arquitectónicos residenciales.Palabras clave: Modernidad, equilibrio, equivalencia, clasificación, catálogo, atributos de la forma moderna, casa moderna cuencana.
AbstractThere is the assumption that domestic architecture within the northern area of Cuenca-Ecuador represents high-qualified examples of modernity in its local context. That is why, this research, in agreement with the National Ecuadorean Institute of Cultural Heritage (INPC), was focused on finding out its modernity degree. A sampling of 11 blocks within the northern area summarized its spatial planning. Its methodology consisted on a visual and photographic analysis, in which 33 houses were identified and assessed, according to modern formal criteria of equilibrium, equivalence and classification; from its variations three architectural typologies were identified.
Keywords: Modernity, equilibrium, equivalence, classification, catalog, attributes of modern form, modern Ecuadorian dwelling.
Persistence of ryegrass, tall fescue and cocksfoot following sequential annual sowings: pasture yield, composition and density in 3 establishment years under sheep grazing in Canterbury
Authors: Maxwell Thomas M R , Edwards Grant R , Cosgrove Gerald P 
Published: June 2020

A long-term pasture persistence trial, consisting of repeated annual sowings, commenced in Canterbury in 2015 and is planned to continue until 2024. Preliminary results of the first 3 years sowings are reported. Each annual sowing used the same randomised block design of eight perennial ryegrass cultivars, one tall fescue and one cocksfoot cultivar, replicated four times. Grasses were drilled into a cultivated seedbed in autumn, with white clover broadcast-sown, then rolled with a Cambridge roller. Except for one 3-week spell in spring and in autumn to accumulate herbage to measure DM yield, botanical composition, morphology and sward density, plots were continuously stocked with sheep to maintain a 3-8 cm sward height from late-August to late-May. Results from the first 12 months following each of the three annual sowings (2015, 2016 and 2017) indicate establishment year had a greater influence on DM yield, botanical composition, grass leaf and stem proportions, and basal cover than did grass species or cultivar. Accumulating data from successive annual sowings and continued monitoring of each will help identify the long-term effect and difference between establishment years, as well as grass persistence traits for inclusion in the Forage Value Index ranking of perennial ryegrass cultivars.
A field survey of soil pH and extractable aluminium in the Ashburton Lakes Catchment, Canterbury, New Zealand.
Authors: Whitley Amy E , Almond Peter C , Moir Jim L , Giona Bucci Monica , Nelson Josh , Moot Derrick J 
Published: June 2020

Soil extractable aluminium (Al) concentrations have a strong impact on the establishment, growthand persistence of pasture legumes. A survey of 21 soil profiles in the Ashburton Lakes catchmentwas conducted to determine the key factors driving extractable Al concentrations. The mean Al (0.02 MCaCl2) concentration was 7.8 mg/kg with the highest values in the top 50 cm of the soil profile. However,there was considerable variation among sites. Landform age, rainfall and depth were all important variables forextractable Al (but R2 was low), while landform type was not. The highest Al concentrations in the 20 cm depthzone were found at the wettest sites in the catchment where rainfall was ≥ 1266 mm and where pH was lowest.Farmers in this catchment could use this knowledge to determine which areas of their farms are most susceptible to elevated Al concentrations and at what depth. This would assist in determining which areas could be targeted for development and which are unsuitable.
Natural history features of the high-country and drylands of the South Island, New Zealand
Authors: Lee William G 
Published: June 2020

The high-country and dryland zone of the South Island of New Zealand includes the Southern Alpsand eastern mountains and basins. Formed by post-Pliocene tectonic, glacial and alluvial processes, theseareas contain a range of landforms across extreme climatic gradients. Diverse habitats support plantsand animals which have a distinctive and long natural history. New Zealand’s short (c. 700 years) historyof human land use has been highly disruptive for indigenous biodiversity. We have misunderstood theeco-evolutionary vulnerabilities of the native biota, the extent of environmental limits, and the impacts ofintroduced weeds and pests. Recent large-scale capture of water and addition of nutrients for agriculture areexcluding indigenous biodiversity in many ecosystems. Predicted climate change and competition for waterresources will exacerbate agricultural impacts, but the remaining indigenous biodiversity can be resilient ifrepresentative areas are protected.
Agricultural intensification, ownership, and landscape change in the Mackenzie Basin
Authors: Brower Ann , Sprague Rowan , Vernotte Marion , McNair Hamish 
Published: June 2020

This article investigates the role of shifting land ownership in landscape change in New Zealand’s Mackenzie Basin. It was hypothesised that ownership patterns influence landscape transformation; and changes in ownership lead to landscape changes. Satellite imagery was used to trace recent landscape changes quantifying a change from brown extensive pastoralism to green irrigated pasture. It was concluded that the change in land ownership following land reform allowed for about half of this agricultural intensification since 2003. Aggregating intensification on new freehold land with that on current pastoral lease changes the story; Crown decisions about disposition or intensification of Crown land account for two-thirds of intensification since 2003. Hence, if current trends in the Mackenzie are to change, the Crown must examine its decision patterns. Change in some form seems likely. The results presented speak to who has the power to make change. The choice and the power reside somewhere in the space between the Commissioner of Crown Lands and the Minister of Land Information.