bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hamsun’s “mal du siècle”
Authors: Conner Tom 
Published: December 2020

My paper expands on several conference themes, specifically “geographical places” and “boundaries,” and will explore the elasticity and intertextual implications of both terms as they apply to national literatures and writers, as well as their porous nature in literary studies (including theory, history, and criticism, according to René Wellek’s classic and still widely accepted triptych of literary studies [Wellek x]). Specifically, I will examine the resonance of the Romantic malaise known in France as “le mal du siècle” and how it might inform a reading of Knut Hamsun’s novel Pan (1894) and shed light on the more than eccentric behavior of its main character, Lieutenant Glahn. The French Romantic writer Chateaubriand (1768-1848), whose slender novel René (1802), with which “le mal du siècle” is most closely associated, represents the epitome of the Romantic hero, who evidently had not drawn his last breath when Hamsun published Pan almost one century later. Upon a closer reading of the two novels, there is more than enough to warrant a comparison. Glahn and René are archetypes of a similar malady afflicting overly sensitive, generally upper-class young men of a nervous and indeed neurotic
disposition.
Assessment of Rapid SARS-CoV-2 Testing with Lateral Flow Immunoassay among Asymptomatic Healthcare Workers in Makati Medical Center
Authors: Benjamin Cherry Lois M. , Ng Jan Patrick O. , Sunga Elija Haziel B. , Sy Darleen M. , Javier Saturnino P. , Uy Milagros , Caoili Janice , Pastores John , Ocampo Arnold , Salvador Artemio , Bodegon R. N. Bernadette 
Published: December 2020

Aims: Corona Virus Disease-19 (COVID-19) is a global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While the gold standard for diagnosis is still reverse transcription Polymerase Chain Reaction (RT-PCR), it is not readily available. Serologic testing is considered to be a faster method of identifying individuals who may have been exposed and developed antibodies against SARS-CoV-2.
Methodology: This was an ambirectional observational study aimed to determine the prevalence of exposure to COVID-19 infection among asymptomatic healthcare workers in Makati Medical Center, a tertiary hospital in the Philippines, using rapid antibody testing (lateral flow immunoassay) in May 2020.
Results: A total of 1557 asymptomatic healthcare workers were included in the study. Majority belonged to the paramedical group (52%). Twenty (1.3%) healthcare workers were IgM positive while 17 (1.1%) tested positive for IgG. Three healthcare workers (0.2%) tested positive for both antibodies. Participants with history of being quarantined who tested positive for either IgM or IgG were significantly higher compared to those who tested negative for both antibodies (55%, 33.3%, 41.2% vs 28.5%, p = 0.036). Those with diabetes had 6.8 times higher risk of being IgM positive and IgG negative (p=0.001). In addition, those with diabetes were more likely (13.6 times) to be positive in both tests (p=0.034).
Conclusion: There was a low prevalence (2.6%) of COVID-19 infection among healthcare workers of Makati Medical Center. Among those with positive serologic test, diabetes mellitus, history of exposure and history of quarantine were risk factors associated with COVID-19 infection.
Conventional Ginger Candy on Premenstural Syndrome among Adolescent Girls
Authors: Bhuvaneswari G. , Gnanamalar S. , Jeevarathinam M. , Devi S.Gayathri 
Published: December 2020

Background: Premenstrual condition is one of the most well-known issues in ladies at their regenerative age. Premenstrual disorder is a condition that influences the feelings, wellbeing, and conduct during specific days of the feminine cycle before her menses. Almost 80% of ladies report at least one manifestation that doesn't generously influence every day functioning, as per the American Family Doctor. In this aspect the current examination was led with the expection to decide the impact of regular ginger candy on premenstrual disorder among young ladies.
Methods: Quasi experimental research design was adopted with 60 samples who met the inclusion criteria. Samples were selected by e purposive sampling technique. Pre-test was conducted by using Numerical pain rating scale and HRQoL scale Questionnaire data was collected. Conventional ginger candy was administered to adolescent girls with routine daily diet. Posttest was conducted after 8 weeks with the same tool. Data were analyzed using SPSS. The Results: The study findings revealed that the severity of Premenstrual pain was reduced compared to before the intervention. HRQoL also improve routine Conventional ginger candy supplementation was effective in reducing the Premenstrual syndrome at the level of p>0.001 in the after the post test.
Conclusion: Conventional ginger candy supplementation is cost effective and easily available, thereby finding can relieve premenstrual pain and associated symptoms, and improve the quality of life among adolescent girls.
Characteristics of the first‐mode vertical vibration of buildings based on earthquake observation records
Authors: Kinoshita Takuya , Nakamura Naohiro , Kashima Toshihide 
Published: December 2020

AbstractThis study focuses on the first‐modal natural periods and damping ratios of buildings in the vertical direction. An auto regression and exogenous (ARX) model is used to identify each vertical natural period and damping ratio. The targets comprise over 3,000 earthquake observation records for 18 buildings comprising reinforced concrete, steel and reinforced concrete, and steel structures. The identified values are summarized for each structural type, and their characteristics are discussed in view of the input amplitude and height of the buildings, compared to the natural period and damping ratio in the horizontal direction. Based on the results, a simple estimation equation is provided for the first‐mode vertical natural period.
A Visible Light and Iron‐mediated Carbocationic Route to Polysubstituted 1‐Halonaphthalenes by Benzannulation using Allylbenzenes and Polyhalomethanes
Authors: Roslan Irwan Iskandar , Zhang Hongwei , Ng Kian‐Hong , Jaenicke Stephan , Chuah Gaik‐Khuan 
Published: December 2020

AbstractA wide array of polysubstituted 1‐bromo and chloronaphthalenes are obtained from coupling of allylbenzenes and polyhalomethanes. The reaction is mediated by iron metal under visible light irradiation and proceeds via a Kharasch addition intermediate followed by intramolecular FeIII mediated Friedel‐Crafts alkylation, with the formation of two Csp2−Csp2 bonds in the process. This method gives easy access to 1‐halonaphthalenes with substituent(s) at C‐5 to C‐8 that are otherwise hard to synthesize.magnified image
Synthesis of Allylboronates via Zweifel‐type Deprotonative Olefination
Authors: Xu Nuo , Xu Jianeng , Zhu Qing , Liu Chao 
Published: December 2020

AbstractA method for the synthesis of allylboronates via Zweifel‐type deprotonative olefination was demonstrated. Tetrasubstituted vinylboronates were used as the substrates. NCS (N‐chlorosuccinimide) was used as a bifunctional additive, electrophile and base. This method exhibited a different elimination strategy in Zweifel type transformation to afford allylboronates. The homo‐alcohols and alkenes were stereoselective synthesized from the obtained allylboronates, demonstrating the synthetic value of this methodology.magnified image
Ferric Heme Superoxide Reductive Transformations to Ferric Heme (Hydro)Peroxide Species: Spectroscopic Characterization and Thermodynamic Implications for H‐Atom Transfer (HAT)
Authors: Kim Hyun , Rogler Patrick J. , Sharma Savita K. , Schaefer Andrew W. , Solomon Edward I. , Karlin Kenneth D. 
Published: December 2020

AbstractA new end‐on low‐spin ferric heme peroxide, [(PIm)FeIII−(O22−)]− (PIm‐P), and subsequently formed hydroperoxide species, [(PIm)FeIII−(OOH)] (PIm‐HP) are generated utilizing the iron‐porphyrinate PIm with its tethered axial base imidazolyl group. Measured thermodynamic parameters, the ferric heme superoxide [(PIm)FeIII−(O2⋅−)] (PIm‐S) reduction potential (E°′) and the PIm‐HP pKa value, lead to the finding of the OO−H bond‐dissociation free energy (BDFE) of PIm‐HP as 69.5 kcal mol−1 using a thermodynamic square scheme and Bordwell relationship. The results are validated by the observed oxidizing ability of PIm‐S via hydrogen‐atom transfer (HAT) compared to that of the F8 superoxide complex, [(F8)FeIII−(O2.−)] (S) (F8=tetrakis(2,6‐difluorophenyl)porphyrinate, without an internally appended axial base imidazolyl), as determined from reactivity comparison of superoxide complexes PIm‐S and S with the hydroxylamine (O‐H) substrates TEMPO‐H and ABNO‐H.
Single‐Molecule Conductance of 1,4‐Azaborine Derivatives as Models of BN‐doped PAHs
Authors: Palomino‐Ruiz Lucía , Rodríguez‐González Sandra , Fallaque Joel G. , Márquez Irene R. , Agraït Nicolás , Díaz Cristina , Leary Edmund , Cuerva Juan M. , Campaña Araceli G. , Martín Fernando , Millán Alba , González M. Teresa 
Published: December 2020

AbstractThe single‐molecule conductance of a series of BN‐acene‐like derivatives has been measured by using scanning tunneling break‐junction techniques. A strategic design of the target molecules has allowed us to include azaborine units in positions that unambiguously ensure electron transport through both heteroatoms, which is relevant for the development of customized BN‐doped nanographenes. We show that the conductance of the anthracene azaborine derivative is comparable to that of the pristine all‐carbon anthracene compound. Notably, this heteroatom substitution has also allowed us to perform similar measurements on the corresponding pentacene‐like compound, which is found to have a similar conductance, thus evidencing that B–N doping could also be used to stabilize and characterize larger acenes for molecular electronics applications. Our conclusions are supported by state‐of‐the‐art transport calculations.
A solvent‐resistance OTS/PDA/O‐PASS composite membrane for water‐in‐oil emulsions separation
Authors: Yang Faming , Xiong Chen , Lian Yingfu , Wang Xiaojun , Wei Zhimei , Long Shengru , Zhang Gang , Yang Jie 
Published: December 2020

AbstractWater‐in‐oil emulsions separation plays a critical role in industrial wastewater treatment. Membrane technology has attracted much interest in water‐in‐oil emulsions separation field for its excellent separation performance and facile processing method. However, versatile membrane with better solvent‐resistance is still absent in chemical industry. In this work, oxidized polyarylene sulfide sulfone (O‐PASS) membrane was severed as substrate, on which a hydrophobicity surface was built via coating of octadecyltrichlorosilane (OTS). And polydopamine (PDA) layer was employed and acted as connector between OTS and O‐PASS membrane due to its abundant active hydroxyl group. The maximum water contact angle was 132.6° indicating good hydrophobicity of the membrane. Finally, the OTS/PDA/O‐PASS composite membranes showed good separation performance for corrosive emulsions: the rejection and flux were 93.0% and 10.0 L/m2h for water‐in‐dichloromethane emulsions, and the rejection and flux were 92.3% and 34.6 L/m2h for water‐in‐n‐hexane emulsions. The OTS/PDA/O‐PASS composite membrane is a new candidate membrane for water‐in‐oil emulsions separation. In addition, the superior performance of the composite membrane under harsh environment conditions ensures its usefulness in resistance aggressive solvent.
Genetic aberrations in Chinese pancreatic cancer patients and their association with anatomic location and disease outcomes
Authors: Lu Junliang , Yu Ruoying , Liu Rui , Liang Xiaolong , Sun Jian , Zhang Hui , Wu Huanwen , Zhang Zhiwen , Shao Yang W. , Guo Junchao , Liang Zhiyong 
Published: December 2020

AbstractObjectivesPancreatic cancer (PC) is one of the most lethal malignancies with an increasing death rate over the years. We performed targeted sequencing and survival analyses on 90 Chinese pancreatic cancer patients, hoping to identify genomic biomarkers associated with clinical outcomes and therapeutic options.MethodGenomic DNA was extracted from formalin‐fixed paraffin‐embedded (FFPE) tissue specimens of 90 pancreatic cancer patients and sequenced. The associations with clinicopathological factors were analyzed.ResultHigh prevalence of driver mutations in KRAS, TP53, CDKN2A, SMAD4, and ARID1A genes were found. Most mutated genes in PC belonged to cell cycle and DNA damage repair pathways. Tumors that arise from the pancreas’ body and tail (BT tumors) displayed a higher ratio of mutated KRAS and TP53 than those that arise from the pancreas’ head and neck (HN tumors), who showed less diverse KRAS subtypes. Patients with a KRAS p.G12R mutated tumor tended to have a prolonged disease‐free survival (DFS) and overall survival (OS) than other KRAS subtypes. Those with an altered ARID1A gene and more than two mutated driver genes tended to have a shorter DFS and OS.ConclusionHN and BT tumors of the pancreas displayed different mutational profiles, which had prognostic significances and indicated different potential therapeutic options.
Cold‐Resistant Nitrogen/Sulfur Dual‐Doped Graphene Fiber Supercapacitors with Solar–Thermal Energy Conversion Effect
Authors: Zhao Tianyu , Yang Dongzhi , Xu Ting , Zhang Ming , Zhang Shiyi , Qin Liyuan , Yu Zhong‐Zhen 
Published: December 2020

AbstractAlthough graphene fiber‐based supercapacitors are promising for wearable electronic devices, the low energy density of electrodes and poor cold resistance of aqueous electrolytes limit their wide application in cold environments. Herein, porous nitrogen/sulfur dual‐doped graphene fibers (NS‐GFs) are synthesized by hydrothermal self‐assembly followed by thermal annealing, exhibiting an excellent capacitive performance of 401 F cm−3 at 400 mA cm−3 because of the synergistic effect of heteroatom dual‐doping. The assembled symmetric all‐solid‐state supercapacitor with polyvinyl alcohol/H2SO4/graphene oxide gel electrolyte exhibits a high capacitance of 221 F cm−3 and a high energy density of 7.7 mWh cm−3 at 80 mA cm−3. Interestingly, solar–thermal energy conversion of the electrolyte with 0.1 wt % graphene oxide extends the operating temperature range of the supercapacitor to 0 °C. Furthermore, the photocatalysis effect of the dual‐doped heteroatoms increases the capacitance of NS‐GFs. At an ambient temperature of 0 °C, the capacitance increases from 0 to 182 F cm−3 under 1 sun irradiation because of the excellent solar light absorption and efficient solar–thermal energy conversion of graphene oxide, preventing the aqueous electrolyte from freezing. The flexible supercapacitor exhibits a long cycle life, good bending resistance, reliable scalability, and ability to power visual electronics, showing great potential for outdoor electronics in cold environments.
A General Approach to Intermolecular Olefin Hydroacylation through Light‐Induced HAT Initiation: An Efficient Synthesis of Long‐Chain Aliphatic Ketones and Functionalized Fatty Acids
Authors: Paul Subhasis , Guin Joyram 
Published: December 2020

AbstractHerein, an operationally simple, environmentally benign and effective method for intermolecular radical hydroacylation of unactivated substrates by employing photo‐induced hydrogen atom transfer (HAT) initiation is described. The use of commercially available and inexpensive photoinitiators (Ph2CO and NHPI) makes the process attractive. The olefin hydroacylation protocol applies to a wide array of substrates bearing numerous functional groups and many complex structural units. The reaction proves to be scalable (up to 5 g). Different functionalized fatty acids, petrochemicals and naturally occurring alkanes can be synthesized with this protocol. A radical chain mechanism is implicated in the process.
An efficient pipeline for ancient DNA mapping and recovery of endogenous ancient DNA from whole‐genome sequencing data
Authors: Xu Wenhao , Lin Yu , Zhao Keliang , Li Haimeng , Tian Yinping , Ngatia Jacob Njaramba , Ma Yue , Sahu Sunil Kumar , Guo Huabing , Guo Xiaosen , Xu Yan Chun , Liu Huan , Kristiansen Karsten , Lan Tianming , Zhou Xinying 
Published: December 2020

AbstractAncient DNA research has developed rapidly over the past few decades due to improvements in PCR and next‐generation sequencing (NGS) technologies, but challenges still exist. One major challenge in relation to ancient DNA research is to recover genuine endogenous ancient DNA sequences from raw sequencing data. This is often difficult due to degradation of ancient DNA and high levels of contamination, especially homologous contamination that has extremely similar genetic background with that of the real ancient DNA. In this study, we collected whole‐genome sequencing (WGS) data from 6 ancient samples to compare different mapping algorithms. To further explore more effective methods to separate endogenous DNA from homologous contaminations, we attempted to recover reads based on ancient DNA specific characteristics of deamination, depurination, and DNA fragmentation with different parameters. We propose a quick and improved pipeline for separating endogenous ancient DNA while simultaneously decreasing homologous contaminations to very low proportions. Our goal in this research was to develop useful recommendations for ancient DNA mapping and for separation of endogenous DNA to facilitate future studies of ancient DNA.
Left ventricular dysfunction in atrial fibrillation and heart failure risk
Authors: Kuo Jen‐Yuan , Chang Sheng‐Hsiung , Sung Kuo‐Tzu , Chi Po‐Ching , Liao Jo‐Nan , Chao Tze‐Fan , Su Cheng‐Huang , Yeh Hung‐I , Hung Chung‐Lieh 
Published: December 2020

AbstractAimsThis study aimed to investigate the functional correlate, clinical relevance, and prognostic implications of novel left ventricular (LV) deformations in patients with atrial fibrillation (AF).Methods and resultsLV deformational indices, including peak global longitudinal strain (GLS), systolic strain rates (SRs), and early diastolic strain rates (SRe) were measured in a large‐scale AF population. We related such measures to key clinical heart failure (HF) markers, conventional echocardiographic ventricular parameters, and clinical outcomes. Among 1483 subjects with newly diagnosed AF (mean age, 71.6 ± 12.4 years; 55.5% male), worsened GLS (mean, − 12.6 ± 3.9%) and strain rates (SRs and SRe: mean, − 0.86 ± 0.27 and 1.25 ± 0.41 1/s, respectively) by our three‐beat measures were independently correlated with higher C‐reactive protein, N‐terminal pro‐B‐type natriuretic peptide, higher E/e′, more impaired LV ejection fraction (LVEF < 50%), lower estimated glomerular filtration rate, permanent AF, and prevalent HF (all P < 0.05). LV deformations by three‐beat analysis well correlated with the respective results of traditional methods. Abnormal GLS (>− 14.7%) was common in our cohort (67.8%) despite an averaged preserved LVEF (58.4 ± 14.2%), with worse GLS and SRe being associated with higher composite HF re‐admissions/death during the 2.9 year follow‐up (inter‐quartile range, 1.6–4.1 years) in multivariate models incorporating key LV indices (LVEF, LV mass index, and E/e′) (all P < 0.001). Sensitivity analysis by excluding those with regional wall motion abnormality showed broadly similar findings. An improved risk reclassification was observed when GLS and SRe were separately added to the LVEF. Comparison of the AF cohort with a fully matched independent non‐AF cohort at the same baseline LVEF level showed a substantially lower GLS [− 13.2 ± 3.8% (AF) vs. 18.1 ± 3.2% (non‐AF)] and higher clinical events rate (hazard ratio, 1.41 [95% confidence interval, 1.14–1.75]; log‐rank P = 0.002) in the AF cohort.ConclusionsImpaired LV function defined by myocardial deformation was common in patients with AF and provides independent prognostic values over conventional measures with improved risk prediction. Our data highlight the need for implementing cardiac deformations in daily practice for patients with AF.
Improved 30 day heart failure rehospitalization prediction through the addition of device‐measured parameters
Authors: Brown Jason R. , Alonso Alvaro , Mazimba Sula , Warman Eduardo N. , Bilchick Kenneth C. 
Published: December 2020

AbstractAimsThis study aimed to improve in‐person clinical evaluation on the day of heart failure (HF) hospitalization discharge by adding device‐measured parameters to predict 30 day HF rehospitalization risk in cardiac resynchronization therapy‐defibrillator (CRT‐D) patients.Methods and resultsIn a cohort of Medicare patients with CRT‐Ds, the independent prognostic value of four device‐measured parameters was assessed relative to typical clinical parameters associated with rehospitalization risk. Medicare registry, claims, and Medtronic CareLink® Network data for these patients were analysed using logistic regression modelling and net reclassification methods. Among 1563 CRT‐D patients, 411 patients had 607 HF hospitalization events during a median 6.3 years of follow‐up. Compared with clinical variables alone, impedance measurements resulted in a 28% improvement between the predicted probabilities of having vs. not having a 30 day HF rehospitalization (relative integrated discrimination improvement = 0.28) and a net 42% improvement in the classification of 30 day HF rehospitalization events and non‐events after an index HF hospitalization (net reclassification index = 0.42; 95% CI: 0.10, 0.74).ConclusionsIn CRT patients, intrathoracic impedance measurements improve prediction of 30 day HF rehospitalization over clinical characteristics alone. The present study provides supportive data for the routine evaluation of intrathoracic impedance prior to discharge in patient with CRT devices. Furthermore, the models developed in this study could be used to design interventions to improve compliance with Medicare reimbursement guidelines regarding 30 day HF rehospitalization.
HAMLET a human milk protein‐lipid complex induces a pro‐inflammatory phenotype of myeloid cells
Authors: Vansarla Goutham , Håkansson Anders P , Bergenfelz Caroline 
Published: December 2020

AbstractHAMLET is a protein‐lipid complex with a specific and broad bactericidal and tumoricidal activity, that lacks cytotoxic activity against healthy cells. In this study, we show that HAMLET also has general immune‐stimulatory effects on primary human monocyte‐derived dendritic cells and macrophages (Mo‐DC and Mo‐M) and murine RAW264.7 macrophages. HAMLET, but not its components alpha‐lactalbumin or oleic acid, induces mature CD14low/–CD83+ Mo‐DC and M1‐like CD14+CD86++ Mo‐M surface phenotypes. Concomitantly, inflammatory mediators, including IL‐2, IL‐6, IL‐10, IL‐12 and MIP‐1α, were released in the supernatant of HAMLET‐stimulated cells, indicating a mainly pro‐inflammatory phenotype. The HAMLET‐induced phenotype was mediated by calcium, NFκB and p38 MAPK signaling in Mo‐DCs and calcium, NFκB and ERK signaling in Mo‐M as inhibitors of these pathways almost completely blocked the induction of mature Mo‐DCs and M1‐like Mo‐M. Compared to unstimulated Mo‐DCs, HAMLET‐stimulated Mo‐DCs were more potent in inducing T cell proliferation and HAMLET‐stimulated macrophages were more efficient in phagocytosis of Streptococcus pneumoniae in vitro. This indicates a functionally activated phenotype of HAMLET‐stimulated DCs and macrophages. Combined, we propose that HAMLET has a two‐fold anti‐bacterial activity; one inducing direct cytotoxic activity, the other indirectly mediating elimination of bacteria by activation of immune cells of the myeloid lineage.