bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-throughput assessment of hemoglobin polymer in single red blood cells from sickle cell patients under controlled oxygen tension
Authors: Di Caprio Giuseppe , Schonbrun Ethan , Gonçalves Bronner P. , Valdez Jose M. , Wood David K. , Higgins John M. 
Published: November 2019

Significance
Sickle cell disease is the first “molecular disease” described more than 100 years ago. All morbidity and mortality are ultimately caused by polymerization of the variant sickle hemoglobin molecule in red blood cells (RBCs). However, despite decades of intense research, we are unable to measure the amount of hemoglobin polymer in individual RBCs with high throughput at arbitrary oxygen tension. We describe a high-throughput method to assess hemoglobin polymer at the single-cell level under controlled oxygen tension. The assay infers hemoglobin polymer fraction by measuring its effect on cellular oxygen affinity. This method provides biomarkers promising to improve management of sickle cell patients and to optimize the development and prioritization of candidate cures.
Oral ionic liquid for the treatment of diet-induced obesity
Authors: Nurunnabi Md , Ibsen Kelly N. , Tanner Eden E. L. , Mitragotri Samir 
Published: November 2019

Significance
Obesity is considered a strong factor in many chronic diseases, including heart disease, diabetes, and cancer. Along with genetics, consumption of excessive fat and cholesterol-rich food are the primary causes of obesity. We have developed an ionic liquid that interacts with fat to form micrometer-sized particles. The ionic liquid prevents the fat from penetrating through the intestinal membrane. We have observed that a regular dose of 10 μL of CAGE (equivalent to a 500-mg human dose) resulted in 12% less body weight gain compared with the rats treated with CAGE. The results from the animal studies support oral CAGE as a promising approach for treating obesity.
IATE 2
Authors: Zorrilla-Agut Paula , Fontenelle Thierry 
Published: November 2019

Abstract
The redevelopment of the European Union’s interinstitutional terminology database IATE (InterActive Terminology
for Europe) has been an opportunity to rethink the technologies, architecture and data structure of the system in order to prepare
it for future challenges, including interoperability, modularity, scalability and data exchange, among other things. This article
describes which strategies are being put in place to allow IATE data – one of the largest multilingual terminology databases in
the world – to be consumed by third-party tools, particularly computer-assisted translation environments (CATEs). The
modernisation of the application, aligning it with the latest software and systems engineering standards and technologies for the
benefit of all users and for improved data management by EU linguists, is also described.
Using open data to create the Catalan IATE e-dictionary
Authors: Vàzquez Mercè , Oliver Antoni , Casademont Elisabeth 
Published: November 2019

AbstractLinguistic resources available in the form of open data are an essential source of information for creating e-dictionaries, but access to these linguistic resources is still limited. This paper presents a method for maximising use of open access linguistic resources and integrating them into specialised e-dictionaries. The method combines automatic compilation of terminology data with the creation of specialised linguistic corpora to produce a Catalan version of the IATE (InterActive Terminology for Europe) database. The paper presents new methodological advances applied here to the production of terminological e-dictionaries, using open access linguistic resources. We observe that, as a result of this new methodology, the Catalan version of the IATE will be able to include specialised economics, law and health dictionaries. In conclusion, the new methodology presented here permits the creation of new models of specialised e-dictionaries, facilitates the compilation of terminology in any language and unifies the access format for terminology data.
EcoLexicon and by-products
Authors: León-Araúz Pilar , Reimerink Arianne , Faber Pamela 
Published: November 2019

Abstract
Reutilization and interoperability are major issues in the fields of knowledge representation and extraction, as
reflected in initiatives such as the Semantic Web and the Linked Open Data Cloud. This paper shows how terminological resources
can be integrated and reused within different types of application. EcoLexicon is a multilingual terminological knowledge base
(TKB) on environmental science that integrates conceptual, linguistic and visual information. It has led to the following
by-products: (i) the EcoLexicon English Corpus; (ii) EcoLexiCAT, a terminology-enhanced translation tool; and (iii) Manzanilla, an
image annotation tool. This paper explains EcoLexicon and its by-products, and shows how the latter exploit and enhance the data
in the TKB.
Molecular insights into the mechanism of substrate recognition of Streptomyces transglutaminases
Authors: Tokai Shota , Uraji Misugi , Hatanaka Tadashi 
Published: November 2019

ABSTRACT
The microbial TGase from Streptomyces mobaraensis has used in various food industries. However, the detailed substrate specificities of TGases from the Streptomyces species toward the natural peptides remains to be unclear. In this study, we conducted the comparison of two different TGases from Streptomyces mobaranensis (SMTG) and Streptomyces cinnamoneus (SCTG). To clarify the region associated with the characteristics of enzymes, we constructed a chimeric enzyme of CM, of which is consisted of N-terminal half of SCTG and C-terminal half of SMTG. To reveal the differences in the substrate specificity between SCTG and SMTG toward natural peptides, we investigated the time dependence of TGase activity on the productivity of cross-linking peptide with tryptic casein and lysine by using LC-MS. We identified two peptides of “VLPVPQK” and “AVPYPQR” as substrates for both of the TGases.
Blood concentrations of small extracellular vesicles are determined by a balance between abundant secretion and rapid clearance
Authors: Matsumoto Akihiro , Takahashi Yuki , Chang Hsin‐Yi , Wu Yi‐Wen , Yamamoto Aki , Ishihama Yasushi , Takakura Yoshinobu 
Published: November 2019

ABSTRACTSmall extracellular vesicles (sEVs) are important mediators of cell–cell communication with respect to diverse physiological processes. To further understand their physiological roles, understanding blood sEV homoeostasis in a quantitative manner is desired. In this study, we propose novel kinetic approaches to estimate the secretion and clearance of mouse plasma–derived sEVs (MP‐sEVs) based on the hypothesis that blood sEV concentrations are determined by a balance between the secretion and clearance of sEVs. Using our specific and sensitive sEV labelling technology, we succeeded in analysing MP‐sEV clearance from the blood after intravenous administration into mice. This revealed the rapid disappearance of MP‐sEVs with a half‐life of approximately 7 min. Moreover, the plasma sEV secretion rate, which is presently impossible to directly evaluate, was calculated as 18 μg/min in mice based on pharmacokinetic (PK) analysis. Next, macrophage‐depleted mice were prepared as a model of disrupted sEV homoeostasis with retarded sEV clearance. MP‐sEV concentrations were increased in macrophage‐depleted mice, which probably reflected a shift in the balance of secretion and clearance. Moreover, the increased MP‐sEV concentration in macrophage‐depleted mice was successfully simulated using calculated clearance rate constant, secretion rate constant and volume of distribution, suggesting the validity of our PK approaches. These results demonstrate that blood sEV concentration homoeostasis can be explained by the dynamics of rapid secretion/clearance.
Calibration simulation for stereoscopic optical systems using optical design software
Authors: Gorevoy A V , Machikhin A S , Batshev V I , Kolyuchkin V Y 
Published: November 2019

Abstract
To reconstruct three-dimensional (3D) structure of objects and measure their geometric parameters using stereoscopic imaging systems, it is necessary to implement a number of algorithms. For higher system efficiency, the choice of these algorithms and mathematical models should be taken into account at the stage of optical system design. We demonstrate the capabilities of optical design software to perform computer simulation of geometrical calibration for stereoscopic systems. The simulation allows comparison of mathematical models used for 3D reconstruction and estimation of 3D measurements errors caused by tolerances of optical elements, temperature variations and other factors. Using this technique, we analyze the design of prism-based stereoscopic system and show that the proposed ray tracing camera model considering pupil aberrations provides high measurement precision. The results of computer simulation are confirmed by experiments with the self-developed stereoscopic system.
Prospects for creating a laser nanolithography system for tasks of diffractive optics and nanophotonics
Authors: Korolkov V P , Shimansky RV , Khomutov V N , Seduhin A G , Nasyrov R K , Kiryanov V P , Kiryanov A V , Zavyalova M A 
Published: November 2019

Abstract
This paper considers the basic concepts of constructing an advanced direct laser writing nanolithographic system dedicated to a high-resolution synthesis of large-sized planar elements of diffractive optics and nanophotonics. The issues of the rational implementation of optical, mechanical and electronic units of the system are solved together with considering the functional structure for a precise computer control of the mentioned units. The proposed design of the opto-mechanical unit aims to reduce significantly the distortions of fabrication of the optical elements due to the use of a new symmetrical two-channel construction and a differential laser interferometer for the radial positioning of a focused laser beam. A complex of issues on constructing a long-working distance superresolving focusing system are also considered alongside. The complex modernization of the nanolithographic system software and hardware complex based on system-on-chip (SoC) using hybrid processors (FPGA+ARM) is considered, which will make the system more universal and portable to various IT platforms.
Tunable liquid crystal astigmatic plate
Authors: Kotova S P , Mayorova A M , Prokopova D V , Samagin S A 
Published: November 2019

AbstractWe proposed two schemes of compact tunable liquid crystal astigmatic plate. The device is a modal spatial light modulator with a specific electrodes configuration. Numerical simulations of operation of the device showed its capability to form astigmatic wave front describing by Z22and Z2-2Zernike polynomials and also by their superposition. Various modes of operation of LC device are considered. The capability of operation as a truncated axicon is shown.
Comparative simulation of spiral zone plates with a relief from silica glass and silver
Authors: Kozlova E S , Kotlyar V V 
Published: November 2019

Abstract
Comparative simulation of optical vortices generation by spiral zone plates with a relief from silver and silica glass using a frequency depended finite difference time domain method. The right circularly polarized Gaussian pulse was used as incident light. An analysis of the Umov-Poynting vector, amplitude and phase distributions in the focal plane shows was the presence of complex optical vortices with an inverse energy flow in its’ centre. Influence of the amplitude spiral zone plate relief height on energy backflow is studied. Comparison of simulation results for two types of spiral zone plate confirms the possibility of using the amplitude analogue instead of the phase zone plate since it is simpler to manufacture.
Investigation of the vortex laser beam shift relative to the optical element using high performance computer systems
Authors: Savelyev D A 
Published: November 2019

Abstract
The spatial distribution of the Gauss-Laguerre beams with circular polarization is investigated subject to the beam position relative to the element, the axicon numerical aperture and order of the vortex phase in the 3D model. Modeling of diffraction is numerically investigated by the finite difference time domain (FDTD) method using high-performance computing. It is shown that using the diffraction axicon, polarization transformations can be carried out in the near zone, which, in particular, is expressed that the number of dark bands corresponds to the m (vortex laser beam number).
Investigation of characteristics of waveguide channels system formed in PDLC with inhomogeneity of the amplitude-phase distribution of forming field
Authors: Dudnik D I , Kvasova I A , Gusachenko K O , Semkin A O , Sharangovich S N 
Published: November 2019

Abstract
This work presents the results of modeling the influence of amplitude, phase and amplitude-phase heterogeneities of the forming field on the spatial distribution of the refractive index profile and, accordingly, the mode composition of radiation capable of propagating in waveguides formed by the holographic method in the photopolymer-liquid crystalline compositions. The spatial distribution of the refractive index is found by solving the system of kinetic equations. The mode composition of the radiation is determined by solving the dispersion equation for TE-modes.
Conventional Raman and surface-enhanced Raman spectroscopy of ascitic fluid
Authors: Bratchenko L A , Bratchenko I A , Artemyev D N , Moryatov A A , Starikova J V , Tupikova E N , Platonov I A , Kozlov S V , Zakharov V P 
Published: November 2019

Abstract
The aim of this study is to analyze the spectral characteristics of ascitic fluid using Raman spectroscopy and surface-enhanced Raman spectroscopy (SERS). The utilization of SERS allows for detection the presence of ascitic fluid components that are not available for revealing when analyzed using conventional Raman spectroscopy. The potential to detect the spectral contribution of a number of pathogenic microorganisms utilizing the proposed SERS-based optical approach has been demonstrated.
Representation of shifted vortex beams of arbitrary order as a combination of nonshifted vortices
Authors: Ustinov A V 
Published: November 2019

Abstract
In this paper, we investigate the focusing of beams with a displaced vortex of arbitrary order. For these purposes, we use the following mathematical model: the beam is represented as a combination of beams having a nonshifted vortex. It is shown theoretically that an optical vortex of an arbitrary integer order m displaced within an axisymmetric beam is equivalent to the finite sum of nonshifted vortices of orders from 0 to m inclusive. If the order of the displaced vortex beam is non-integer, then the sum is replaced by an infinite series.
Numerical simulation was carried out under sharp focusing conditions in the Debye approximation. The obtained pictures of the focused displaced vortex beams, regardless of the order of the vortex and the magnitude of the displacement, have a qualitatively identical form - the shape of the Crescent. To obtain focal pictures of another type, the illuminating beam must contain an optical vortex of the opposite sign. The obtained results are relevant for multichannel communication systems based on the separation of laser beams carrying orbital angular momentum.
Refinements to the microwave waveguide material parameters measurements. Case study
Authors: Zeyde K M , Sharov V V , Malkin A I 
Published: November 2019

Abstract
This work presents the results of experimental measurements of permittivity and permeability of materials (dried pine, paraffin, acrylic resin, bitumen, polypropylene and texolite) that has a comparative values. The laboratory installation compile from waveguides 23x10 mm that provides the frequency range 8 – 12 GHz. The results processing lay not only in comparison with the existing data, but also in investigation of physical conditions that should be taken into account for waveguide experiment setup. The main aim is to establish the variation of electro physical parameters of the material measured in waveguides and in free space. Selection of reference material samples is the main part of this work.
Spectrometry of molecular interactions in clusters
Authors: Nepomnyashchaya E K 
Published: November 2019

Abstract
Molecular interactions in clusters have always been an important problem as to theoretical and experimental studies. In this paper, we describe a combination of spectrometric techniques for experimental analysis of molecular interactions and dynamics in clusters. We study different types of biological molecules (for instance, well-known albumin molecule) and metallic nanoparticles (for instance, Fe3O4) while their binding in solutions with help of laser correlation and absorption spectrometric techniques. Results of spectrometry of biomolecules interacting with metals show different degrees of association between different molecules and nanoparticles. This paper offers original data on spectrometry of such processes, which is useful both for medical and bioelectronics problems.
Analysis of diffraction efficiency of phase gratings in dependence of duty cycle and depth
Authors: Meshalkin A Yu , Podlipnov V V , Ustinov A V , Achimova E A 
Published: November 2019

Abstract
The analysis of dependence of diffraction efficiency on duty cycle and modulation depth of phase gratings with rectangular and Gaussian profile was performed by means of specially designed program. An Angular Spectrum method applied for monochromatic light propagation in far field through phase grating was used for calculation of diffraction efficiency of gratings. Diffraction efficiency maps of 0-5th diffraction orders were obtained for different grating profiles. It is shown that changing the duty cycle of grating makes it possible to tune smoothly the diffraction efficiency and to redirect the light intensity in required orders.
Experimental study of the photon structures holographic formation by Bessel-like light beams in photopolymer materials
Authors: Dolgirev V O , Dudnik D I , Semkin A O , Sharangovich S N 
Published: November 2019

Abstract
This paper presents experimental results of holographic formation of diffractive optical elements for the Gaussian light beams transformation into Bessel-like (one-dimensional and two-dimensional) in photopolymer materials using amplitude transparency (AT).
Synthesis of silicon nanowires using plasma chemical etching process for solar cell applications
Authors: Mokshin P V , Juneja S , Pavelyev V S 
Published: November 2019

Abstract
Recently, research on silicon nanowire solar cells has been developed rapidly and it is one of the very young research fields. The production of highly oriented long silicon nanowires is a challenging task. Here, in this article we report the optimization of successful synthesis of highly oriented long silicon nanowires on silicon substrates by plasma chemical etching process. The produced silicon structures were firstly examined using scanning electron microscopy (SEM). The SEM results clearly show the highly oriented nanowires on the silicon substrate. The flowing carrier gas, temperature, pressure and voltage are main parameters responsible for the formation of the silicon nanowires. The successful synthesis of silicon nanowires shows bright perspectives for further research on silicon nanostructure properties.
Study of electrical and optical properties of a new composite material based on carbon nanotubes and titanium oxide
Authors: Hussein S M R H , Gavad A M 
Published: November 2019

Abstract
In this regard, the aim of this work is to study the features of the atomic structure and to predict the electronic energy characteristics of the composite material based on carbon nanotube and ceramic particles – titanium oxide using computer simulation methods. To achieve this goal, the following tasks were solved: construction of a geometric model of the rutile nanoparticle; identification of the energy-stable configuration of the composite based on the carbon nanotube and rutile nanoparticles; determination of the electron-energy characteristics of the composite. The structure of the composite was selected so that the total energy of the composite in absolute value was less than that of the individual tube and rutile the enthalpy of the reaction of the tube and rutile becomes negative, which means that the formation of such a nanocomposite is energetically advantageous. one of the most important applications of such composite is to act as photocatalyst for some chemical reactions because of electrical characteristics and high optical absorption.
Investigation of the formation of hybrid polarized laser beams using a four-sector polarization converter
Authors: Podlipnov V V , Karpeev S V 
Published: November 2019

Abstract
The paper presents the manufacturing technology of a four-sector polarization converter for the formation of beams with different hybrid polarizations. A calcite crystal was used as a transducer, two opposite sectors of which were etched to a depth of 1970 nm. The work is demonstrated and experimental patterns of the total intensity distribution, x-components and y-components in the wavelength range of 500-800 nm for the light transmitted through the transducer and also in the focus distribution are shown. The theoretical and experimental dependence of the degree of conversion is described depending on the parameters of manufacturing the sectors of a four-sector converter. For this purpose, a tunable laser was used in the experiment. The operation of the transducer for the vortex field was simulated.
Autoregressive models of random fields on the circle
Authors: Krasheninnikov V R , Kuvayskova Yu E , Subbotin A U 
Published: November 2019

Abstract
At present, the vast majority of known image models are varieties of random fields defined on rectangular flat grids or grids of higher dimension. In some practical situations, images have a circular or radial-circular structure. For example, an image of a facies (a thin film of dried biological fluid), an eye, a biological cell, a flower, a slice of a tree trunk, etc. This circumstance requires the development of appropriate models of random fields describing images of this type. This paper proposes autoregressive models of homogeneous and inhomogeneous random fields defined on a circular spiral. The problem of correlation analysis of such models is considered. Examples of imitation of circular images are given. This paper proposes linear autoregressive models of homogeneous and inhomogeneous random fields defined on a circle. The samples of these fields are defined on a circular or spiral grid. The next field value is a linear combination of several previous values and a standard random variable. Expressions of the correlation function of these fields are given depending on the values of the autoregression parameters. A graphic representation of the correlation function on a circle and examples of simulated images are presented in the figures.
A comparative study of the optimal and interpolation methods for restoration a stationary continuous signal from discrete values
Authors: Maksimov A I , Sergeyev V V 
Published: November 2019

Abstract
In this paper, we consider the task of restoration of a continuous signal by its discrete values. We compare the optimal and interpolation restoration techniques for the continuous-discrete observation model. The expression for the root-mean-square error of the restoration of a stationary continuous signal from its discrete values is derived. For the optimal restoration case, the signal is reconstructed by the means of an optimal restoration filter. For the interpolation restoration, the signal is reconstructed with the use of linear interpolation. The results of a comparison of the root-mean-square errors of the optimal restoration and interpolation procedures with the same parameters of the input signal, additive noise, and dynamic distortion are presented.