bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 3 mm Chemical Exploration of Small Organics in Class I YSOs
Authors: Gal Romane Le , Öberg Karin I. , Huang Jane , Law Charles J. , Ménard François , Lefloch Bertrand , Vastel Charlotte , Lopez-Sepulcre Ana , Favre Cécile , Bianchi Eleonora , Ceccarelli Cecilia 
Published: July 2020

Abstract
There is mounting evidence that the composition and structure of planetary systems are intimately linked to their birth environments. During the past decade, several spectral surveys probed the chemistry of the earliest stages of star formation and late planet-forming disks. However, very little is known about the chemistry of intermediate protostellar stages, i.e., class I young stellar objects (YSOs), where planet formation may have already begun. We present here the first results of a 3 mm spectral survey performed with the IRAM 30 m telescope to investigate the chemistry of a sample of seven class I YSOs located in the Taurus star-forming region. These sources were selected to embrace the wide diversity identified for low-mass protostellar envelope and disk systems. We present detections and upper limits of 13 small (N
atoms ≤ 3) C, N, O, and S carriers—namely, CO, HCO+, HCN, HNC, CN, N2H+, C2H, CS, SO, HCS+, C2S, SO2, and OCS—and some of their D, 13C, 15N, 18O, 17O, and 34S isotopologues. Together, these species provide constraints on gas-phase C/N/O ratios, D and 15N fractionation, source temperature, and UV exposure, as well as the overall S chemistry. We find substantial evidence of chemical differentiation among our source sample, some of which can be traced back to class I physical parameters, such as the disk-to-envelope mass ratio (proxy for class I evolutionary stage), source luminosity, and UV field strength. Overall, these first results allow us to start investigating the astrochemistry of class I objects; however, interferometric observations are needed to differentiate envelope versus disk chemistry.
A Global Nonhydrostatic Atmospheric Model with a Mass- and Energy-conserving Vertically Implicit Correction (VIC) Scheme
Authors: Ge 葛華 Huazhi 志 , Li Cheng , Zhang Xi , Lee Dongwook 
Published: July 2020

Abstract
Global nonhydrostatic atmospheric models are becoming increasingly important for studying the climates of planets and exoplanets. However, such models suffer from computational difficulties due to the large aspect ratio between the horizontal and vertical directions. To overcome this problem, we developed a global model using a vertically implicit correction (VIC) scheme in which the integration time step is no longer limited by the vertical propagation of acoustic waves. We proved that our model, based on the Athena++ framework and its extension for planetary atmospheres—SNAP (Simulating Nonhydrostatic Atmospheres on Planets), rigorously conserves mass and energy in finite-volume simulations. We found that traditional numerical stabilizers such as hyperviscosity and divergence damping are not needed when using the VIC scheme, which greatly simplifies the numerical implementation and improves stability. We present simulation results ranging from 1D linear waves to 3D global circulations with and without the VIC scheme. These tests demonstrate that our formulation correctly tracks local turbulent motions, produces Kelvin–Helmholtz instability, and generates a super-rotating jet on hot Jupiters. Employing this VIC scheme improves the computational efficiency of global simulations by more than two orders of magnitude compared to an explicit model and facilitates the capability of simulating a wide range of planetary atmospheres both regionally and globally.
A Mid-infrared Flare in the Active Galaxy MCG-02-04-026: Dust Echo of a Nuclear Transient Event
Authors: Sun Luming , Jiang Ning , Wang Tinggui , Zhou Hongyan , Dou Liming , Yang Chenwei , Pan Xiang , Sheng Zhenfeng , Zhong Zhihao , Yan Lin , Li Ge 
Published: July 2020

Abstract
We report the discovery of a mid-infrared (MIR) flare using Wide field Infrared Survey Explorer data in the center of the nearby Seyfert 1.9 galaxy MCG-02-04-026. The MIR flare began in the first half of 2014, peaked around the end of 2015, and faded in 2017. During these years, energy of more than 7 × 1050 erg was released in the infrared, and the flare’s MIR color was generally turning red. We detected neither optical nor ultraviolet (UV) variation corresponding to the MIR flare based on available data. We explained the MIR flare using a dust echo model in which the radiative transfer is involved. The MIR flare can be well explained as thermal reradiation from dust heated by UV–optical photons of a primary nuclear transient event. Although the transient event was not seen directly owing to dust obscuration, we can infer that it may produce a total energy of at least ∼1051 erg, most of which was released in less than ∼3 yr. The nature of the transient event could be a stellar tidal disruption event by the central supermassive black hole (SMBH), or a sudden enhancement of the existing accretion flow onto the SMBH, or a supernova that was particularly bright.
Mapping Outflowing Gas in the Fermi Bubbles: A UV Absorption Survey of the Galactic Nuclear Wind*
Authors: Ashley Trisha , Fox Andrew J. , Jenkins Edward B. , Wakker Bart P. , Bordoloi Rongmon , Lockman Felix J. , Savage Blair D. , Karim Tanveer 
Published: July 2020

Abstract
Using new ultraviolet (UV) spectra of five background quasars from the Cosmic Origins Spectrograph on the Hubble Space Telescope, we analyze the low-latitude (

) regions of the Fermi Bubbles, the giant gamma-ray-emitting lobes at the Galactic Center. We combine these data with previous UV and atomic hydrogen (H i) data sets to build a comprehensive picture of the kinematics and metal column densities of the cool outflowing clouds entrained in the Fermi Bubbles. We find that the number of UV absorption components per sight line decreases as a function of increasing latitude, suggesting that the outflowing clouds become less common with increasing latitude. The Fermi Bubble H i clouds are accelerated up to b ∼ 7°, whereas when we model the UV Fermi Bubbles clouds’ deprojected flow velocities, we find that they are flat or even accelerating with distance from the Galactic center. This trend, which holds in both the northern and southern hemispheres, indicates that the nuclear outflow accelerates clouds throughout the Fermi Bubbles or has an acceleration phase followed by a coasting phase. Finally, we note the existence of several blueshifted high-velocity clouds at latitudes exceeding ∼30°, whose velocities cannot be explained by gas clouds confined to the inside of the gamma-ray-defined Fermi Bubbles. These anomalous-velocity clouds are likely in front of the Fermi Bubbles and could be remnants from past nuclear outflows. Overall, these observations form a valuable set of empirical data on the properties of cool gas in nuclear winds from star-forming galaxies.
Semianalytic Expressions for the Isolation and Coupling of Mixed Modes
Authors: Ong 王 J. M. Joel 加冕 , Basu Sarbani 
Published: July 2020

Abstract
In the oscillation spectra of giant stars, nonradial modes may be seen to undergo avoided crossings, which produce a characteristic “mode bumping” of the otherwise uniform asymptotic p- and g-mode patterns in their respective echelle diagrams. Avoided crossings evolve very quickly relative to typical observational errors and are therefore extremely useful in determining precise ages of stars, particularly in subgiants. This phenomenon is caused by coupling between modes in the p- and g-mode cavities that are near resonance with each other. Most theoretical analyses of the coupling between these mode cavities rely on the Jeffreys–Wentzel–Kramers–Brillouin approach, which is strictly speaking inapplicable to the low-order g modes observed in subgiants or the low-order p modes seen in very evolved red giants. We present both a nonasymptotic prescription for isolating the two mode cavities, as well as a perturbative (and also nonasymptotic) description of the coupling between them, which we show to hold good for the low-order g and p modes in these physical situations. Finally, we discuss how these results may be applied to modeling subgiant stars and determining their global properties from oscillation frequencies. We also make our code for all of these computations publicly available.
Low Water Outgassing from (24) Themis and (65) Cybele: 3.1 μm Near-IR Spectral Implications
Authors: O’Rourke L. , Müller T. G. , Biver N. , Bockelée-Morvan D. , Hasegawa S. , Valtchanov I. , Küppers M. , Fornasier S. , Campins H. , Fujiwara H. , Teyssier D. , Lim T. 
Published: July 2020

Abstract
Asteroids (24) Themis and (65) Cybele have an absorption feature at 3.1 μm reported to be directly linked to surface water ice. We searched for water vapor escaping from these asteroids with the Herschel Space Observatory Heterodyne Instrument for the Far Infrared. While no H2O line emission was detected, we obtain sensitive 3σ water production rate upper limits of Q(H2O) < 4.1 × 1026 molecules s−1 for Themis and Q(H2O) < 7.6 × 1026 molecules s−1 for Cybele. Using a thermophysical model, we merge data from the Subaru/Cooled Mid-Infrared Camera and Spectrometer and the Herschel/Spectral and Photometric Imaging Receiver with the contents of a multi-observatory database to derive new radiometric properties for these two asteroids. For Themis, we find a thermal inertia

J m−2 s−1/2 K−1, a diameter

km, and a geometric V-band albedo p

V
= 0.07 ± 0.01. For Cybele, we obtain a thermal inertia

J m−2 s−1/2 K−1, a diameter 282 ± 9 km, and an albedo p

V
= 0.042 ± 0.005. Using all inputs, we estimate that water ice intimately mixed with the asteroids’ dark surface material would cover <0.0017% (for Themis) and <0.0033% (for Cybele) of their surfaces, while an areal mixture with very clean ice (Bond albedo 0.8 for Themis and 0.7 for Cybele) would cover <2.2% (for Themis) and <1.5% (for Cybele) of their surfaces. While surface (and subsurface) water ice may exist in small localized amounts on both asteroids, it is not the reason for the observed 3.1 μm absorption feature.
Extended Point-spread Functions for Deep Astronomical Imaging Surveys
Authors: Baena-Gallé Roberto , Infante-Sainz Raúl , Akhlaghi Mohammad , Trujillo Ignacio , Knapen Johan H. 
Published: July 2020

Abstract
The low surface brightness (LSB) universe is one of the last frontiers in observational astronomy. However, uncovering the information contained in ultra-deep imaging is technically challenging. In this contribution, we present one of the fundamental tools of LSB astronomers: correcting for the extended Point-Spread Function (PSF), which is critical to characterize the LSB properties of astronomical images. We show how to build the extended PSF (approximately 5′ in radius), in 5 bands (grizY), of one of the most important modern deep surveys: the Hyper-Suprime Camera (HSC) one on the 8.2 m Subaru telescope. These PSFs have been obtained by sampling individual point-like sources at different brightness. The techniques used here can be applied to the next generation of deep astronomical imaging surveys as the LSST.
HPLC MS/MS method development for the quantitative determination of verapamil hydrochloride from Caco-2 cell monolayers
Authors: Logoyda Liliya , Herasymiuk Maksym , Popovych Dariya , Pidruchna Svitlana , Hlushok Vitaliy , Herasymiuk Nazar , Zarivna Nadiya 
Published: July 2020

Aim. An understanding of the role that transporters, in particular P-glycoprotein (P-gp), can play in the absorption, distribution, metabolism and excretion (ADME) of candidate drugs, and an assessment of how these processes might impact on toxicity and the potential for drug-drug interactions in the clinic, is required to support drug development and registration. It is therefore necessary to validate preclinical assays for the in vitro evaluation of candidate drugs as substrates or inhibitors of human P-gp. 2. A simple, rapid HPLC MS/MS method was developed for determination of verapamil hydrochloride from confluent Caco-2 monolayers and from aqueous solution.
Materials and methods. Chromatography was achieved on Discovery C18, 50 × 2.1 mm, 5 μm column. Samples were chromatographed in a gradient mode (eluent A (acetonitrile – water – formic acid, 5 : 95 : 0.1 v/v), eluent B (acetonitrile – formic acid, 100 : 0.1 v/v)). The initial content of the eluent B is 0%, which increases linearly by 1.0 min to 100% and to 1.01 min returns to the initial 0%. The mobile phase was delivered at a flow rate of 0.4 mL/min into the mass spectrometer ESI chamber. The sample volume was 5 μl.
Results. Under these conditions, verapamil hydrochloride was eluted at 1.08 min. A linear response function was established at 1 – 100 ng/mL. The regression equation for the analysis was Y = 0.0162x + 0.00391 with coefficient of correction (R2) = 0.9992. According to the Caco-2 test results, verapamil showed low permeability. It should be noted that the recovery value for verapamil hydrochloride is 102.69%. The within-run coefficients of variation ranged between 0.336% and 0.617% for verapamil. The within-run percentages of nominal concentrations ranged between 98.82% and 100.62% for verapamil. The between-run coefficients of variation ranged between 0.334% and 0.612% for verapamil. The between-run percentages of nominal concentrations ranged between 98.97% and 101.76% for verapamil. The assay values on both the occasions (intra- and inter-day) were found to be within the accepted limits.
Conclusion. From results of analysis, it can be concluded that developed method is simple and rapid for determination of verapamil hydrochloride from confluent Caco-2 monolayers and from aqueous solution. Acquired results demonstrate that proposed strategy can be effortlessly and advantageously applied for examination of verapamil hydrochloride from Caco-2 cell monolayers.
Gestalt-thérapeute, clown praticien, installé à l’île de Groix (Morbihan)
Authors: Devinat François 
Published: July 2020

L’auteur est parti en retraite sur un îlot breton dénué de tout « psy ». Le praticien Gestaltiste qu’il reste s’interroge : va-t-il reprendre du service pour rompre l’isolement des îliens ou bien se vouer à contempler l’infinitude de l’océan ? Entre les deux, son cœur balance. Il a apporté ici toute sa bibliothèque de « psy », son cabinet est installé. Se jeter à l’eau, oui. Mais dans quelle posture et vers quel horizon ? Sur l’ajustement créateur et une posture à inventer, une méditation poétique et forte.
Une histoire d’amour et de musique
Authors: Gassin Marie-Laure 
Published: July 2020

Mue par la Gestalt dès l’université, curieuse insatiable, je la compare avec les autres thérapeutiques. Une grande partie de mon existence fut assidue à rechercher les ressorts de la thérapie. Avec le recul, je porte un regard englobant sur le paysage thérapeutique, à partir d’autres théories, comme de mon expérience vécue. Ce texte « tricote » trois brins : des questions de posture et méthode, des observations, des retours sur mon parcours. Soit une fugue pour thérapie bien tempérée, une histoire d’amour avec les séductions du début puis les déceptions, et les retrouvailles d’une longue relation.
Parents' Involvement in the Education of their Children with Autism: Related Research and its Results
Authors: Chaidi Irene , Drigas Athanasios 
Published: July 2020

Parents' active participation in the diagnostic and therapeutic process of children with developmental disorders is considered by experts to be an important factor in the long-term struggle to educate people with autism. According to relevant bibliographical references, the benefits of parental education have been proven for decades.
Researchers [1], [2] underline the positive outcomes of parent behavior training programs for children with developmental disabilities.
Surveys conducted to date show that results show parents can implement the strategies they have recently learned and are generally very pleased with parent's education programs. However, findings related to children's communication and socioemotional skills, parent-child interactions were unclear [3].
Adoptive T Cell Therapy with IL-12–Preconditioned Low-Avidity T Cells Prevents Exhaustion and Results in Enhanced T Cell Activation, Enhanced Tumor Clearance, and Decreased Risk for Autoimmunity
Authors: Tucker Christopher G. , Mitchell Jason S. , Martinov Tijana , Burbach Brandon J. , Beura Lalit K. , Wilson Joseph C. , Dwyer Alexander J. , Singh Lovejot M. , Mescher Matthew F. , Fife Brian T. 
Published: July 2020

Abstract
Optimal ex vivo expansion protocols of tumor-specific T cells followed by adoptive cell therapy must yield T cells able to home to tumors and effectively kill them. Our previous study demonstrated ex vivo activation in the presence of IL-12–induced optimal CD8+ T cell expansion and melanoma regression; however, adverse side effects, including autoimmunity, can occur. This may be due to transfer of high-avidity self-specific T cells. In this study, we compared mouse low- and high-avidity T cells targeting the tumor Ag tyrosinase-related protein 2 (TRP2). Not surprisingly, high-avidity T cells provide superior tumor control, yet low-avidity T cells can promote tumor regression. The addition of IL-12 during in vitro expansion boosts low-avidity T cell responsiveness, tumor regression, and prevents T cell exhaustion. In this study, we demonstrate that IL-12–primed T cells are resistant to PD-1/PD-L1–mediated suppression and retain effector function. Importantly, IL-12 preconditioning prevented exhaustion as LAG-3, PD-1, and TOX were decreased while simultaneously increasing KLRG1. Using intravital imaging, we also determined that high-avidity T cells have sustained contacts with intratumoral dendritic cells and tumor targets compared with low-avidity T cells. However, with Ag overexpression, this defect is overcome, and low-avidity T cells control tumor growth. Taken together, these data illustrate that low-avidity T cells can be therapeutically beneficial if cocultured with IL-12 cytokine during in vitro expansion and highly effective in vivo if Ag is not limiting. Clinically, low-avidity T cells provide a safer alternative to high-avidity, TCR-engineered T cells, as IL-12–primed, low-avidity T cells cause less autoimmune vitiligo.
Risk Assessment and Practice of Occupational Safety among Food Handlers in Lamingo, Jos North Local Government Area of Plateau State.
Authors: Tagurum YO , Miner CA , Daboer JC , Eze HC , John SA , Luka N , Chingle MP , Chirdan OO 
Published: July 2020

Background: Food handlers are people who work in a food facility and perform duties that involve the preparation, storage or serving the food. Due to the activities involved in cooking, they are exposed to various hazards. Little is known about knowledge and practice of occupational safety among food handlers in Jos, Plateau state
Methods: A cross sectional study was conducted in February 2017 among 73 food handlers. Quantitative data was collected on knowledge, risk assessment and occupational safety practices among the food handlers. Data was analysed using Epi Info 3.5.4.
Results: Only 13.7% of the respondents were found to have good level of knowledge of occupational safety and health, while more than half (60.3%) of the respondents were found to work in high risk environment, with 16.4% in low risk environment. There was a poor level of practice of occupational safety among 60.3% of the respondents. Respondents agreed that efforts towards occupational safety such as resource commitment, continuous safety training, availability of safety materials in different languages, comfortable work environment and facilities with regular maintenance as well as safety policy enforcement would improve occupational safety practices
Conclusion: This study revealed that majority of food handlers in Lamingo, Jos worked in high risk environment and in spite of this; there was a low level of knowledge and practice of occupational safety among them. Therefore, there is the need to improve work place safety and knowledge of occupational safety among food handlers. This can be achieved by conducting regular educational programmes and workshops about the importance of safety at work, and teaching the food handlers that occupational safety is also their responsibility, not just their employers alone.
EFFICACY OF PATRAPINDA SWEDA AND MATRA BASTI (COMBINED THERAPY) IN THE MANAGEMENT OF SANDHIVATA (OSTEO ARTHRITIS)
Authors: Ramadas Patil Rupali 
Published: July 2020

According to WHO Sandhivata is the second commonest musculoskeletal problem in the world after backache. The present clinical trial was conducted to evaluate the efficacy of Ptrapinda Sweda and Matra Basti (combined Chikitsa) in the management of Sandhivata.
Total 30 patients were selected for clinical trial. All the 30 patients were treated with Patrpinda Sweda for first 8 days and Vatanashak tail Matra basti for next 8 days. Results were assessed according to a standard grading system for Shool, Graha, Sparshasahatva and Shotha. Functional impairment was assessed by observing walking time. There was complete relief of Shool in 36.6%, Sparshasahatva in 43.3% and Graha in 43%. Significant improvement was observed in Shotha and in walking time. Marked improvement was observed in Shool in 40%, Sparshasahatva in 33.3% and Graha in 40%.
Hence it is concluded from the study that the combination of Patrpinda sweda and Matra Basti is a reliable management of Sandhivata, which should be repeated at least 6 monthly to maintain the symptomless state.
Padrões urbanos facilitadores da recarga de aquíferos
Authors: Da Nóbrega Oliveira Aline , Koide Sergio , Leite Costa Maria Elisa , De Lima Bezerra Maria do Carmo 
Published: July 2020

A forma de ocupação do solo nas cidades, proveniente de padrões urbanisitcos que não dialogam com o meio físico tem sido responsáveis por impactos no ciclo hidrológico devido a excessiva impermeabilização que contribui para diminuição da infiltração das águas e aumento de seu escoamento superficial.Nesse contexto, destaca-se a importância da análise e definição de metodologias de desenho urbnao que promovam padrões urbanos sensiveis a água. O presente trabalho estuda os fundamentos conceituais que explicam o funcionamento do ciclo hidrólógico para identificar padrões urbanos que reduzam o escomento superfical e os impactos sobre o meio fisico e construido nas cidades. Como método se uiliza :(i)Simulação do comportamento do escoamento superficial em área de pré urbanização;(ii) simulações realizadas em uma parcela urbana com projeto de loteamento com modelo tradicional adontando um padrão de urbanismo disperso;e (iii) simulação da mesma fração utilizando padrões urbanísticos sensiveis à águas previamente estudados; Como resultado se obteve, que o escoamento superficial é bastante reduzido com proposta de urbanismo sensivel à agua confirmando a relação entre o desenho urbano e sua capacidade de garantir recarga de aquíferos.