bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ganghuo Kanggan Decoction in Influenza: Integrating Network Pharmacology and In Vivo Pharmacological Evaluation
Authors: Lai Yanni , Zhang Qiong , Long Haishan , Han Tiantian , Li Geng , Zhan Shaofeng , Li Yiwei , Li Zonghui , Jiang Yong , Liu Xiaohong 
Published: December 2020

Background:Ganghuo Kanggan decoction (GHKGD) is a clinical experience prescription used for the treatment of viral pneumonia in the Lingnan area of China, and its clinical effect is remarkable. However, the mechanism of GHKGD in influenza is still unclear.Objective:To predict the active components and signaling pathway of GHKGD and to explore its therapeutic mechanism in influenza and to verified itin vivousing network pharmacology.Methods:The potential active components and therapeutic targets of GHKGD in the treatment of influenza were hypothesized through a series of network pharmacological strategies, including compound screening, target prediction and pathway enrichment analysis. Based on the target network and enrichment results, a mouse model of influenza A virus (IAV) infection was established to evaluate the therapeutic effect of GHKGD on influenza and to verify the possible molecular mechanism predicted by network pharmacology.Results:A total of 116 candidate active compounds and 17 potential targets were identified. The results of the potential target enrichment analysis suggested GHKGD may involve the RLR signaling pathway to reduce inflammation in the lungs.In vivoexperiments showed that GHKGD had a protective effect on pneumonia caused by IAV-infected mice. Compared with the untreated group, the weight loss in the GHKGD group in the BALB/c mice decreased, and the inflammatory pathological changes in lung tissue were reduced (p&lt; 0.05). The expression of NP protein and the virus titers in lung were significantly decreased (p&lt; 0.05). The protein expression of RIG-I, NF-kB, and STAT1 and the level of MAVS and IRF3/7 mRNA were remarkably inhibited in GHKGD group (p&lt; 0.05). After the treatment with GHKGD, the level of Th1 cytokines (IFN-γ, TNF-α, IL-2) was increased, while the expression of Th2 (IL-5, IL4) cytokines was reduced (p&lt; 0.05).Conclusion:Through a network pharmacology strategy andin vivoexperiments, the multi-target and multi-component pharmacological characteristics of GHKGD in the treatment of influenza were revealed, and regulation of the RLR signaling pathway during the anti-influenza process was confirmed. This study provides a theoretical basis for the research and development of new drugs from GHKGD.
Stress Reduction Techniques for Health Care Providers Dealing With Severe Coronavirus Infections (SARS, MERS, and COVID-19): A Rapid Review
Authors: Callus Edward , Bassola Barbara , Fiolo Valentina , Bertoldo Enrico G. , Pagliuca Silvana , Lusignani Maura 
Published: December 2020

ObjectiveA rapid review was conducted to identify the most effective stress reduction techniques for health care providers dealing with patients infected with severe coronavirus (SARS, MERS, and COVID-19).MethodsPubMed, PsychInfo, Embase, and CINAHL databases were searched to identify relevant studies. Searches were restricted by date (2000 until present). All empirical quantitative and qualitative studies in which relaxation techniques of various types implemented on health care providers caring for patients during severe coronavirus pandemics and articles that consider the implementation of mental health care services considered to be pertinent, such as commentaries, were included.ResultsFourteen studies met the selection criteria, most of which were recommendations. Only one study described a digital intervention, and user satisfaction was measured. In the recommendations, both organizational and individual self-care interventions were suggested.ConclusionsFurther research is necessary to establish tailor-made effective stress reduction interventions for this population, during these challenging and particular times.
Executive Dysfunction Associated With the Primary Psychopathic Features of Borderline Personality Disorder
Authors: López-Villatoro José M. , Diaz-Marsá Marina , Mellor-Marsá Blanca , De la Vega Irene , Carrasco José L. 
Published: December 2020

Purpose: The aim of the present study is to investigate whether the presence of psychopathic features in BPD is related to dysfunction in executive functions and other neuropsychological functions in these patients.Methods: 82 patients diagnosed with borderline personality disorder and 54 control subjects were studied through clinical and neuropsychological evaluation protocols and the Levenson Psychopathy Inventory.Results: BPD patients showed significantly higher scores on both primary (F1) and secondary (F2) global rates of psychopathy, than controls. The results for these patients also showed a statistically significant association between high scores in primary psychopathy and deficits in executive functions. However, no associations were found between the scores of secondary psychopathy and executive dysfunction.Conclusion: Primary psychopathic features present in patients with BPD are associated with patterns of executive dysfunction. It would therefore be interesting to investigate the role of cognitive rehabilitation in the empathy dysfunctions within these disorders.
Targeted encouragement of GP consultations for possible cancer symptoms: a randomised controlled trial
Authors: Laake Jean-Pierre , Vulkan Daniel , Quaife Samantha L , Hamilton William T , Martins Tanimola , Waller Jo , Parmar Dharmishta , Sasieni Peter , Duffy Stephen W 
Published: December 2020

BackgroundFor some common cancers, survival is lower in the UK than in comparable high-income countries.AimTo assess the effectiveness of a targeted postal intervention (to promote awareness of cancer symptoms and earlier help seeking) on patient consultation rates.Design and settingA two-arm randomised controlled trial was carried out on patients aged 50–84 years registered at 23 general practices in rural and urban areas of Greater London, Greater Manchester, and the North East of England.MethodPatients who had not had a consultation at their general practice in the previous 12 months and had at least two other risk factors for late presentation with cancer were randomised to intervention and control arms. The intervention consisted of a posted letter and leaflet. Primary outcome was the number of consultations at the practice with patients randomised to each arm in the 6 months subsequent to posting the intervention. All patients with outcome data were included in the intention-to-treat analyses.ResultsIn total, 1513 patients were individually randomised to the intervention (n= 783) and control (n= 730) arms between Nov 2016 — May 2017; outcome data were available for 749 and 705 patients, respectively, with a statistically significantly higher rate of consultation in the intervention arm compared with the control arm: 436 versus 335 consultations (relative risk 1.40, 95% confidence interval = 1.11 to 1.77,P= 0.004). There was, however, no difference in the numbers of patients consulting.ConclusionTargeted interventions of this nature can change behaviour; there is a need to develop interventions that can be more effective at engaging patients with primary care. This study demonstrates that targeted interventions promoting both awareness of possible cancer symptoms and earlier health seeking, can change behaviour. There is a need to develop and test interventions that can be more effective at engaging the most at-risk patients.
Predicting the risk of prostate cancer in asymptomatic men: a cohort study to develop and validate a novel algorithm
Authors: Hippisley-Cox Julia , Coupland Carol 
Published: December 2020

BackgroundDiagnosis of prostate cancer at an early stage can potentially identify tumours when intervention may improve treatment options and survival.AimTo develop and validate an equation to predict absolute risk of prostate cancer in asymptomatic men with prostate specific antigen (PSA) tests in primary care.Design and settingCohort study using data from English general practices, held in the QResearch database.MethodRoutine data were collected from 1098 QResearch English general practices linked to mortality, hospital, and cancer records for model development. Two separate sets of practices were used for validation. In total, there were 844 455 men aged 25–84 years with PSA tests recorded who were free of prostate cancer at baseline in the derivation cohort; the validation cohorts comprised 292 084 and 316 583 men. The primary outcome was incident prostate cancer. Cox proportional hazards models were used to derive 10-year risk equations. Measures of performance were determined in both validation cohorts.ResultsThere were 40 821 incident cases of prostate cancer in the derivation cohort. The risk equation included PSA level, age, deprivation, ethnicity, smoking status, serious mental illness, diabetes, BMI, and family history of prostate cancer. The risk equation explained 70.4% (95% CI = 69.2 to 71.6) of the variation in time to diagnosis of prostate cancer (R2) (D statistic 3.15, 95% CI = 3.06 to 3.25; Harrell’s C-index 0.917, 95% CI = 0.915 to 0.919). Two-step approach had higher sensitivity than a fixed PSA threshold at identifying prostate cancer cases (identifying 68.2% versus 43.9% of cases), high-grade cancers (49.2% versus 40.3%), and deaths (67.0% versus 31.5%).ConclusionThe risk equation provided valid measures of absolute risk and had higher sensitivity for incident prostate cancer, high-grade cancers, and prostate cancer mortality than a simple approach based on age and PSA threshold.
Natural history of non-bullous impetigo: a systematic review of time to resolution or improvement without antibiotic treatment
Authors: Hoffmann Tammy C , Peiris Ruwani , Glasziou Paul , Cleo Gina , Mar Chris Del 
Published: December 2020

BackgroundNon-bullous impetigo is typically treated with antibiotics. However, the duration of symptoms without their use has not been established, which hampers informed decision making about antibiotic use.AimTo determine the natural history of non-bullous impetigo.Design and settingSystematic review.MethodThe authors searched PubMed up to January 2020, as well as reference lists of articles identified in the search. Eligible studies involved participants with impetigo in either the placebo group of randomised trials, or in single-group prognostic studies that did not use antibiotics and measured time to resolution or improvement. A modified version of a risk of bias assessment for prognostic studies was used. Outcomes were percentage of participants who had either symptom resolution, symptom improvement, or failed to improve at any timepoint. Adverse event data were also extracted.ResultsSeven randomised trials (557 placebo group participants) were identified. At about 7 days, the percentage of participants classified as resolved ranged from 13% to 74% across the studies, whereas the percentage classified as ‘failure to improve’ ranged from 16% to 41%. The rate of adverse effects was low. Incomplete reporting of some details limited assessment of risk of bias.ConclusionAlthough some uncertainty around the natural history of non-bullous impetigo remains, symptoms resolve in some patients by about 7 days without using antibiotics, with about one-quarter of patients not improving. Immediate antibiotic use may not be mandatory, and discussions with patients should include the expected course of untreated impetigo and careful consideration of the benefits and harms of antibiotic use.
Maternal depression and non-specific health complaints in the offspring: a cross-sectional study in Danish primary care
Authors: Lyngsøe Bente Kjær , Rytter Dorte , Munk-Olsen Trine , Vestergaard Claus Høstrup , Christensen Kaj Sparle , Bech Bodil Hammer 
Published: December 2020

BackgroundMaternal depression has been linked to adverse outcomes in the offspring. Existing literature is mainly based on parental reports, which can be an unreliable source when the parent has depression.AimTo explore if maternal depression was associated with daily health complaints and low self-assessed health (SAH) in the offspring.Design and settingParticipants were 45 727 children from the Danish National Birth Cohort recruited between 1996 and 2002. At 11-year follow-up, mothers and their children were invited to complete a questionnaire. Maternal depression was categorised into: no depression, first-time treatment, continued treatment, post-treatment, and relapse.MethodBinomial regression was used to estimate the adjusted prevalence proportion ratio (aPPR) of frequent health complaints and low SAH in children of mothers with depression compared to children of mothers without depression.ResultsThe prevalence of any daily health complaint was 11.4%, daily somatic complaints 4.1%, daily mental complaints 8.9%, both daily mental and somatic complaints 1.5%, and low SAH 5.3%. Children of mothers with depression (any category) were more likely to report a daily health complaint: first-time treatment aPPR 1.35 (95% confidence interval [CI] = 0.96 to 1.85), continued treatment aPPR 1.59 (95% CI = 1.37 to 1.85), post-treatment aPPR 1.30 (95% CI = 1.20 to 1.41), and relapse aPPR 1.56 (95% CI = 1.35 to 1.79). Children of mothers with depression were also more likely to report low SAH: first-time treatment aPPR 1.58 (95% CI = 0.99 to 2.54), continued treatment aPPR 1.86 (95% CI = 1.51 to 2.28), post-treatment aPPR 1.34 (95% CI = 1.19 to 1.50), and relapse aPPR 1.56 (95% CI = 1.26 to 1.93). Girls had a higher prevalence of mental and somatic health complaints and more often reported low SAH compared to boys.ConclusionTreatment of maternal depression was associated with higher prevalence of daily health complaints and low SAH in the offspring at age 11 years. The association was strongest for children of mothers with continued depression or relapse.
Korelasi Nilai HbA1c dengan Kadar Kolesterol Total pada Pasien Diabetes Mellitus Tipe 2
Authors: Susilo Ayu Sabrina , Zulfian Zulfian , Artini Ika 
Published: December 2020

Latar Belakang: Diabetes mellitus (DM) merupakan penyakit metabolik kronik akibat sel β pankreas mengalami penurunan produksi insulin, atau tubuh mengalami inefektifitas insulin. Berdasarkan data IDF jumlah penderita DM di Indonesia dari 9,1 juta jiwa pada tahun 2014 diperkirakan akan terus meningkat pada tahun 2035 dengan jumlah 14,1 juta jiwa. Dengan data tersebut peringkat ke-5 penderita DM di dunia diduduki oleh Indonesia. Tujuan: Untuk mengetahui korelasi antara nilai HbA1c dengan kadar kolesterol total pada pasien DM tipe 2 di Rumah Sakit Pertamina Bintang Amin Bandar Lampung tahun 2019. Metode Penelitian: Jenis Penelitian ini adalah analitik korelatif dengan metode cross sectional menggunakan purposive sampling sebanyak 48 sampel pasien DM tipe 2 yang memenuhi kriteria inkulsi. Pengambilan data dimulai pada bulan Januari-Februari 2020. Data yang digunakan yaitu data sekunder berupa rekam medik. Data dievaluasi dengan uji Spearman. Hasil Penelitian: Didapatkan sampel penelitian berjumlah 48 pasien DM tipe 2 dengan nilai HbA1c ≥9% yaitu sebanyak 30 pasien (62,5%), untuk nilai HbA1c <9% yaitu sebanyak 18 pasien (37,5%) dan kadar kolesterol total ≥200mg/dl yaitu sebanyak 29 pasien (60,4%), untuk kadar kolesterol total <200mg/dl yaitu sebanyak 19 pasien (39,6%). Hasil korelasi Spearman didapatkan nilai p=0,030 dan nilai r=+0,314, karena nilai p=0,030 <0,05 sehingga dapat dinyatakan Ha diterima dan Ho dinyatakan ditolak atau terdapat korelasi yang bermakna, dengan r=0,314 dapat diartikan kekuatan korelasi sedang positif antara nilai HbA1c dengan kadar kolesterol total pada pasien DM tipe 2.Kesimpulan: Terdapat korelasi yang bermakna antara Nilai HbA1c dengan kadar kolesterol total pada pasien DM tipe 2 dengan p-value= 0,030.
Penentuan Tata Letak Gudang Sparepart Non Genuine Pada Bengkel Mobil di Surabaya dengan Metode Dedicated Storage
Authors: Kelvin  , Pram Eliyah Yuliana  , Sri Rahayu  
Published: December 2020

Abstrak—Gudang merupakan tempat kegiatan yang berhubungan dengan penyimpanan barang. Manajemen gudang yang baik tentunya akan membantu mempercepat proses keluar dan masuk barang. Permasalahan yang dihadapi sebuah bengkel mobil resmi yang berada di Surabaya adalah tidak adanya manajemen penataan gudang yang baik, khususnya pada gudang sparepart non genuine. Sparetpart dengan jumlah lebih dari 90 jenis part tidak tertata dengan baik, sehingga mengakibatkan pencarian sparepart yang dibutuhkan menjadi sulit karena lokasi barang yang tidak terdeteksi. Untuk mengatasi permasalahan tersebut, perlu dilakukan perbaikan tata letak gudang dengan menggunakan metode yang sesuai. Salah satu metode yang dapat diterapkan adalah metode Dedicated storage. Metode ini menentukan lokasi yang tetap untuk setiap jenis barang berdasarkan jumlah dan jarak perpindahannya. Sehingga setiap barang nantinya akan memiliki lokasi yang pasti dan jarak ditempuh setiap barang akan menjadi lebih pendek. Data yang diperlukan dalam analisis ini adalah data jenis barang, volume barang, jumlah keluar dan masuk barang, jarak perpindahan barang. Dari hasil analisis pada gudang sparepart non genuine didapatkan 2 kelompok jenis barang yang ditata, yaitu jenis sparepart berupa cairan / basah, dan jenis sparepart kering. Dari 2 kelompok jenis sparepart tersebut dibagi ke dalam 6 (enam) lokasi penyimpanan yang baru dengan 5 (lima) rak memuat barang bersifat basah dan 1 (satu) rak etalase memuat barang bersifat kering. Hasil perhitungan jarak perpindahan sparepart dengan penataan lokasi yang baru didapatkan sebesar 12.942,2 meter perbulan, dimana angka ini berkurang sebanyak 24% dari 17.047,6 meter perbulan sebelum dilakukan perbaikan.
The Photospheric Temperatures of Betelgeuse during the Great Dimming of 2019/2020: No New Dust Required
Authors: Harper Graham M. , Guinan Edward F. , Wasatonic Richard , Ryde Nils 
Published: December 2020

Abstract
The processes that shape the extended atmospheres of red supergiants, heat their chromospheres, create molecular reservoirs, drive mass loss, and create dust remain poorly understood. Betelgeuse’s V-band “Great Dimming” event of 2019 September/2020 February and its subsequent rapid brightening provides a rare opportunity to study these phenomena. Two different explanations have emerged to explain the dimming; new dust appeared in our line of sight attenuating the photospheric light, or a large portion of the photosphere had cooled. Here we present five years of Wing three-filter (A, B, and C band) TiO and near-IR photometry obtained at the Wasatonic Observatory. These reveal that parts of the photosphere had a mean effective temperature (T
eff) significantly lower than that found by Levesque & Massey. Synthetic photometry from MARCS-model photospheres and spectra reveal that the V band, TiO index, and C-band photometry, and previously reported 4000–6800 Å spectra can be quantitatively reproduced if there are multiple photospheric components, as hinted at by Very Large Telescope (VLT)-SPHERE images in Montargès et al. If the cooler component has ΔT
eff ≥ 250 K cooler than 3650 K, then no new dust is required to explain the available empirical constraints. A coincidence of the dominant short- (∼430 days) and long-period (∼5.8 yr) V-band variations occurred near the time of deep minimum (Guinan et al. 2019a). This is in tandem with the strong correlation of V mag and photospheric radial velocities, recently reported by Dupree et al. (2020b). These suggest that the cooling of a large fraction of the visible star has a dynamic origin related to the photospheric motions, perhaps arising from pulsation or large-scale convective motions.
L’urbanisation rurale en Chine : transformations sociales et effets d’aubaine économiques. Le cas de la cité universitaire Daxuecheng dans la périphérie de la métropole cantonaise
Authors: Guibert Christophe , Taunay Benjamin 
Published: December 2020

En quoi l’urbanisation rurale en Chine transforme-t-elle l’espace physique et structure-t-elle l’espace social ? Cette question fondamentale, en période d’importantes mutations de la société chinoise, est ici proposée à l’aune d’un cas singulier. La cité universitaire Daxuecheng , dans la proche banlieue de Canton sur l’île de Xiao Guwei , terrain convoqué dans ce travail, a été soumise à d’importantes transformations en un « temps court » à la suite de l’impulsion volontariste des politiques d’État. Cet ordonnancement rapide – une décennie – permet de justifier l’analyse selon laquelle en un même espace physique cohabitent ou se superposent des populations aux usages du lieu et aux caractéristiques sociales très différenciés.
Global attractors, exponential attractors and determining modes for the three dimensional Kelvin-Voigt fluids with "fading memory"
Authors: Mohan Manil T. 
Published: December 2020

<p style='text-indent:20px;'>The three-dimensional viscoelastic fluid flow equations, arising from the motion of Kelvin-Voigt (Kelvin-Voight) fluids in bounded domains is considered in this work. We investigate the long-term dynamics of such viscoelastic fluid flow equations with "fading memory" (non-autonomous). We first establish the existence of an absorbing ball in appropriate spaces for the semigroup defined for the Kelvin-Voigt fluid flow equations of order one with "fading memory" (transformed autonomous coupled system). Then, we prove that the semigroup is asymptotically compact, and hence we establish the existence of a global attractor for the semigroup. We provide estimates for the number of determining modes for both asymptotic as well as for trajectories on the global attractor. Once the differentiability of the semigroup with respect to initial	data is established, we show that the global attractor has finite Hausdorff as well as	fractal dimensions. We also show the existence of an exponential attractor for the semigroup associated with the transformed (equivalent) autonomous Kelvin-Voigt fluid flow equations with "fading memory". Finally, we show that the semigroup has Ladyzhenskaya's squeezing property and hence is quasi-stable, which also implies the existence of global as well as exponential attractor having finite fractal dimension.</p>
SELF-ADAPTING FAÇADE SYSTEMS: EXPERIMENTATION REGARDING THE EXPLOITATION OF THERMAL DILATION
Authors: Petriccione Livio , Fulchir Fabio , Chinellato Francesco 
Published: December 2020

ABSTRACTAn original and innovative solar device orientation system is illustrated, together with the results of research and experimentation. The system proposed uses only the force generated by natural thermal dilation, without the help of motors, computerized devices or external energy sources, thus overcoming some critical aspects of the self-adaptive type of building envelopes used up until now. In the course of the research a mathematical model was developed to correlate the variation of the environmental temperature with the consequent expansion of the dilating elements of the system. The results of the tests carried out confirmed an excellent correspondence between the theoretical results and the experimentation. The state of the art of the research has all its theoretical aspects defined and some partial prototypes created. It is planned to build some complete prototypes with the realistic prospect of productive development.
Photography, painting, and prints in Ladakh and Zangskar. Intermediality and transmediality
Authors: Linrothe Rob 
Published: December 2020

The central thesis of this essay is that one of the most important aspects of the pioneering use of photographic portraits of teachers in the late 19th and early 20th century in Western Himalayan Buddhist contexts is its ongoing visual relationship to and with pre-photographic media, including sculpture, printing, and especially painting. Evidence shows that the most common compositions for early portrait photographs drew closely on earlier templates already well-established by painting and sculpture.