bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Convection Representation and Model Resolution on Diurnal Precipitation Cycle Over the Indian Monsoon Region: Toward a Convection‐Permitting Regional Climate Simulation
Authors: Konduru Rakesh Teja , Takahashi Hiroshi G. 
Published: July 2020

AbstractThis study investigated the reproducibility of rainfall characteristics of the Indian summer monsoon using a regional climate model (RCM), focusing on the convection representation and model horizontal grid resolution. To understand the importance of convection representation and model horizontal grid resolution, the study employed the Weather Research and Forecasting model WRFv3.8.1 as the RCM. Two series of experiments, that is, cumulus parameterization on/off (CON/COFF), were performed for the monsoon with three different spatial resolutions. Three contrasting monsoon years were selected for the simulations. The simulated rainfalls were evaluated with the India Meteorological Department data set and Tropical Rainfall Measurement Mission 3B42 Version 7. The results revealed that COFF captured fundamental aspects of the rainfall characteristics, such as diurnal cycle, rainfall intensity, and rainfall frequency. Over central India, in COFF, the diurnal precipitation peaks were simulated in afternoon/evening in close agreement with the observations. However, the diurnal precipitation peak in CON appeared 3–6 hr earlier than the observations. The diurnal precipitation variation was more associated with the horizontal grid resolution of the numerical model than representation of convection. Additionally, COFF could simulate diurnally propagating rainfall systems over the Bay of Bengal. Over the Indian land area, COFF simulated less‐frequent intense precipitation systems, whereas CON simulated more‐frequent widespread weak precipitation. This study demonstrated that convection representation is very important for simulation of diurnal rainfall systems over the Indian monsoon region, although refinement of model horizontal grid resolution is required over mountainous regions, where precipitation is closely related to orography.
Ocean‐Only FAFMIP: Understanding Regional Patterns of Ocean Heat Content and Dynamic Sea Level Change
Authors: Todd Alexander , Zanna Laure , Couldrey Matthew , Gregory Jonathan , Wu Quran , Church John A. , Farneti Riccardo , Navarro‐Labastida René , Lyu Kewei , Saenko Oleg , Yang Duo , Zhang Xuebin 
Published: July 2020

AbstractThere is large uncertainty in the future regional sea level change under anthropogenic climate change. Our study presents and uses a novel design of ocean general circulation model (OGCM) experiments to investigate the ocean's response to surface buoyancy and momentum flux perturbations without atmosphere‐ocean feedbacks (e.g., without surface restoring or bulk formulae), as part of the Flux‐Anomaly‐Forced Model Intercomparison Project (FAFMIP). In an ensemble of OGCMs forced with identical surface flux perturbations, simulated dynamic sea level (DSL) and ocean heat content (OHC) change demonstrate considerable disagreement. In the North Atlantic, the disagreement in DSL and OHC change between models is mainly due to differences in the residual (resolved and eddy) circulation change, with a large spread in the Atlantic meridional overturning circulation (AMOC) weakening (20–50%). In the western North Pacific, OHC change is similar among the OGCM ensemble, but the contributing physical processes differ. For the Southern Ocean, isopycnal and diapycnal mixing change dominate the spread in OHC change. In addition, a component of the atmosphere‐ocean feedbacks are quantified by comparing coupled, atmosphere‐ocean GCM (AOGCM) and OGCM FAFMIP experiments with consistent ocean models. We find that there is 10% more AMOC weakening in AOGCMs relative to OGCMs, since the extratropical North Atlantic SST cooling due to heat redistribution amplifies the surface heat flux perturbation. This component of the atmosphere‐ocean feedbacks enhances the pattern of North Atlantic OHC and DSL change, with relatively stronger increases and decreases in the tropics and extratropics, respectively.
MSS/1: Single‐Station and Single‐Event Marsquake Inversion
Authors: Drilleau Mélanie , Beucler Éric , Lognonné Philippe , Panning Mark P. , Knapmeyer‐Endrun Brigitte , Banerdt W. Bruce , Beghein Caroline , Ceylan Savas , van Driel Martin , Joshi Rakshit , Kawamura Taichi , Khan Amir , Menina Sabrina , Rivoldini Attilio , Samuel Henri , Stähler Simon , Xu Haotian , Bonnin Mickaël , Clinton John , Giardini Domenico , Kenda Balthasar , Lekic Vedran , Mocquet Antoine , Murdoch Naomi , Schimmel Martin , Smrekar Suzanne E. , Stutzmann Éléonore , Tauzin Benoit , Tharimena Saikiran 
Published: July 2020

AbstractSEIS, the seismometer of the InSight mission, which landed on Mars on 26 November 2018, is monitoring the seismic activity of the planet. The goal of the Mars Structure Service (MSS) is to provide, as a mission product, the first average 1‐D velocity model of Mars from the recorded InSight data. Prior to the mission, methodologies have been developed and tested to allow the location of the seismic events and estimation of the radial structure, using surface waves and body waves arrival times, and receiver functions. The paper describes these validation tests and compares the performance of the different algorithms to constrain the velocity model below the InSight station and estimate the 1‐D average model over the great circle path between source and receiver. These tests were performed in the frame of a blind test, during which synthetic data were inverted. In order to propagate the data uncertainties on the output model distribution, Bayesian inversion techniques are mainly used. The limitations and strengths of the methods are assessed. The results show the potential of the MSS approach to retrieve the structure of the crust and underlying mantle. However, at this time, large quakes with clear surface waves have not yet been recorded by SEIS, which makes the estimation of the 1‐D average seismic velocity model challenging. Additional locatable events, especially at large epicentral distances, and development of new techniques to fully investigate the data, will ultimately provide more constraints on the crust and mantle of Mars.
Lateral Velocity Gradients in the African Lower Mantle Inferred From Slowness Space Observations of Multipathing
Authors: Ward Jamie , Nowacki Andy , Rost Sebastian 
Published: July 2020

AbstractLarge low‐velocity provinces (LLVPs) are hypothesized to be purely thermal features or possess some chemical heterogeneity but which exactly remains ambiguous. Regional seismology studies typically use travel time residuals and multipathing identification in the waveforms to infer properties of LLVPs. These studies have not fully analyzed all available information such as measuring the direction and inclination of the arrivals. These measurements would provide more constraints of LLVP properties such as the boundary velocity gradient and help determine their nature. Here, we use array seismology to measure backazimuth (direction) and horizontal slowness (inclination) of arriving waves to identify structures causing multipathing and wavefield perturbation. Following this, we use full‐wavefield forward modeling to estimate the gradients required to produce the observed multipathing. We use SKS and SKKS data from 83 events sampling the African LLVP, which has been extensively studied providing a good comparison to our observations. We find evidence for structures at heights of up to 600 km above the core‐mantle boundary causing multipathing and wavefield perturbation. Forward modeling shows gradients of up to 0.7% δVs per 100 km (0.0005 km s−1 km−1) can produce multipathing with similar backazimuth and horizontal slowness to our observations. This is an order of magnitude lower than the previous strongest estimates of −3% δVs per 50 km (0.0044 km s−1 km−1). As this is lower than that predicted for both thermal and thermochemical structures, lateral velocity gradients capable of producing multipathing are not necessarily evidence for a thermochemical nature.
Photon‐Stimulated Desorption of MgS as a Potential Source of Sulfur in Mercury's Exosphere
Authors: Schaible Micah J. , Sarantos Menelaos , Anzures Brendan A. , Parman Stephen W. , Orlando Thomas M. 
Published: July 2020

AbstractMercury has a relatively high sulfur content on its surface, and a signal consistent with ionized atomic sulfur (S+) was observed by the fast ion plasma spectrometer (FIPS) instrument on the MESSENGER spacecraft. To help confirm this assignment and to better constrain the sources of exospheric sulfur at Mercury, 193 nm photon‐stimulated desorption (PSD) of neutral sulfur atoms (S0) from MgS substrates was studied using resonance‐enhanced multiphoton ionization (REMPI) spectroscopy and time‐of‐flight (TOF) mass spectrometry. Though the PSD process is inherently nonthermal, the measured velocities of ejected S0 were fit using flux‐weighted Maxwellian distributions with translation energies <E> expressed as translational “temperatures” Ttrans = <E>/μkB. A bimodal distribution consisting of both thermal (Ttrans = 300 K) and suprathermal (Ttrans > 1,000 K) components in roughly a 2:1 ratio was found to best fit the data. The PSD cross‐section was measured to be approximately 4 × 10−22 cm2 and, together with the velocity distributions, was used to calculate the PSD source rate of S0 into the exosphere of Mercury. Exosphere simulations using the calculated rates demonstrate that PSD is likely the primary source of S0 in Mercury's exosphere at low (<1,000 km) altitudes.
Introduction to the Special Issue: Exploration of the Activity of Asteroid (101955) Bennu
Authors: Hergenrother C. W. , Adam C. D. , Chesley S. R. , Lauretta D. S. 
Published: July 2020

AbstractNear‐Earth asteroid (101955) Bennu is an active asteroid experiencing mass loss. The activity manifests itself in the form of ejection events emitting up to hundreds of millimeter‐ to centimeter‐scale particles. The Origins, Spectral Interpretation, Resource Identification, and Security‐Regolith Explorer spacecraft monitored particle activity for a 10‐month period that included Bennu's perihelion and aphelion. Novel and classical methods were utilized to detect the particles and characterize their orbital and physical properties. Roughly 30% of the observed particle mass escaped to heliocentric orbit. A majority of particles fell back onto the surface of Bennu after ejection, with the longest‐lived particle surviving for 6 days on a temporary orbit. Particle ejection events appear to preferentially take place in the afternoon and evening and from low latitudes, although they can occur at any time or latitude. The reaccumulation of material is biased toward low latitudes resulting in the possible in‐fill of craters and growth of Bennu's equatorial bulge. Of the potential mechanisms behind this activity that were investigated in focused studies, meteoroid impacts, thermal fracturing, and ricochet—but not water ice sublimation—were found to be consistent with observations. While phyllosilicate dehydration was not investigated with a focused study, it remains a possible mechanism. These mechanisms are not unique to Bennu, suggesting that many near‐Earth asteroids may exhibit activity that has gone undetected thus far. Spacecraft missions with wide‐field imagers are encouraged to further characterize this phenomenon.
Photonic Floquet topological insulators in a fractal lattice
Authors: Yang Zhaoju , Lustig Eran , Lumer Yaakov , Segev Mordechai 
Published: July 2020

AbstractWe present Floquet fractal topological insulators: photonic topological insulators in a fractal-dimensional lattice consisting of helical waveguides. The helical modulation induces an artificial gauge field and leads to a trivial-to-topological phase transition. The quasi-energy spectrum shows the existence of topological edge states corresponding to real-space Chern number 1. We study the propagation of light along the outer edges of the fractal lattice and find that wavepackets move along the edges without penetrating into the bulk or backscattering even in the presence of disorder. In a similar vein, we find that the inner edges of the fractal lattice also exhibit robust transport when the fractal is of sufficiently high generation. Finally, we find topological edge states that span the circumference of a hybrid half-fractal, half-honeycomb lattice, passing from the edge of the honeycomb lattice to the edge of the fractal structure virtually without scattering, despite the transition from two dimensions to a fractal dimension. Our system offers a realizable experimental platform to study topological fractals and provides new directions for exploring topological physics.
Radiogenomics for predicting p53 status, PD-L1 expression, and prognosis with machine learning in pancreatic cancer
Authors: Iwatate Yosuke , Hoshino Isamu , Yokota Hajime , Ishige Fumitaka , Itami Makiko , Mori Yasukuni , Chiba Satoshi , Arimitsu Hidehito , Yanagibashi Hiroo , Nagase Hiroki , Takayama Wataru 
Published: July 2020

Abstract
Background
Radiogenomics is an emerging field that integrates “Radiomics” and “Genomics”. In the current study, we aimed to predict the genetic information of pancreatic tumours in a simple, inexpensive, and non-invasive manner, using cancer imaging analysis and radiogenomics. We focused on p53 mutations, which are highly implicated in pancreatic ductal adenocarcinoma (PDAC), and PD-L1, a biomarker for immune checkpoint inhibitor-based therapies.

Methods
Overall, 107 patients diagnosed with PDAC were retrospectively examined. The relationship between p53 mutations as well as PD-L1 abnormal expression and clinicopathological factors was investigated using immunohistochemistry. Imaging features (IFs) were extracted from CT scans and were used to create prediction models of p53 and PD-L1 status.

Results
We found that p53 and PD-L1 are significant independent prognostic factors (P = 0.008, 0.013, respectively). The area under the curve for p53 and PD-L1 predictive models was 0.795 and 0.683, respectively. Radiogenomics-predicted p53 mutations were significantly associated with poor prognosis (P = 0.015), whereas the predicted abnormal expression of PD-L1 was not significant (P = 0.096).

Conclusions
Radiogenomics could predict p53 mutations and in turn the prognosis of PDAC patients. Hence, prediction of genetic information using radiogenomic analysis may aid in the development of precision medicine.
Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma
Authors: Chen Yu-Pei , Yin Jian-Hua , Li Wen-Fei , Li Han-Jie , Chen Dong-Ping , Zhang Cui-Juan , Lv Jia-Wei , Wang Ya-Qin , Li Xiao-Min , Li Jun-Yan , Zhang Pan-Pan , Li Ying-Qin , He Qing-Mei , Yang Xiao-Jing , Lei Yuan , Tang Ling-Long , Zhou Guan-Qun , Mao Yan-Ping , Wei Chen , Xiong Ke-Xu , Zhang Hong-Bo , Zhu Shi-Da , Hou Yong , Sun Ying , Dean Michael , Amit Ido , Wu Kui , Kuang Dong-Ming , Li Gui-Bo , Liu Na , Ma Jun 
Published: July 2020

AbstractNasopharyngeal carcinoma (NPC) is an aggressive malignancy with extremely skewed ethnic and geographic distributions. Increasing evidence indicates that targeting the tumor microenvironment (TME) represents a promising therapeutic approach in NPC, highlighting an urgent need to deepen the understanding of the complex NPC TME. Here, we generated single-cell transcriptome profiles for 7581 malignant cells and 40,285 immune cells from fifteen primary NPC tumors and one normal sample. We revealed malignant signatures capturing intratumoral transcriptional heterogeneity and predicting aggressiveness of malignant cells. Diverse immune cell subtypes were identified, including novel subtypes such as CLEC9A+ dendritic cells (DCs). We further revealed transcriptional regulators underlying immune cell diversity, and cell–cell interaction analyses highlighted promising immunotherapeutic targets in NPC. Moreover, we established the immune subtype-specific signatures, and demonstrated that the signatures of macrophages, plasmacytoid dendritic cells (pDCs), CLEC9A+ DCs, natural killer (NK) cells, and plasma cells were significantly associated with improved survival outcomes in NPC. Taken together, our findings represent a unique resource providing in-depth insights into the cellular heterogeneity of NPC TME and highlight potential biomarkers for anticancer treatment and risk stratification, laying a new foundation for precision therapies in NPC.
Comparative analysis of cell lineage differentiation during hepatogenesis in humans and mice at the single-cell transcriptome level
Authors: Wang Xin , Yang Li , Wang Yan-Chun , Xu Zi-Ran , Feng Ye , Zhang Jing , Wang Yi , Xu Cheng-Ran 
Published: July 2020

AbstractDuring embryogenesis, the liver is the site of hepatogenesis and hematopoiesis and contains many cell lineages derived from the endoderm and mesoderm. However, the characteristics and developmental programs of many of these cell lineages remain unclear, especially in humans. Here, we performed single-cell RNA sequencing of whole human and mouse fetal livers throughout development. We identified four cell lineage families of endoderm-derived, erythroid, non-erythroid hematopoietic, and mesoderm-derived non-hematopoietic cells, and defined the developmental pathways of the major cell lineage families. In both humans and mice, we identified novel markers of hepatic lineages and an ID3+subpopulation of hepatoblasts as well as verified that hepatoblast differentiation follows the “default-directed” model. Additionally, we found that human but not mouse fetal hepatocytes display heterogeneity associated with expression of metabolism-related genes. We described the developmental process of erythroid progenitor cells during human and mouse hematopoiesis. Moreover, despite the general conservation of cell differentiation programs between species, we observed different cell lineage compositions during hematopoiesis in the human and mouse fetal livers. Taken together, these results reveal the dynamic cell landscape of fetal liver development and illustrate the similarities and differences in liver development between species, providing an extensive resource for inducing various liver cell lineages in vitro.
The emergence of magnetic ordering at complex oxide interfaces tuned by defects
Authors: Park D.-S. , Rata A. D. , Maznichenko I. V. , Ostanin S. , Gan Y. L. , Agrestini S. , Rees G. J. , Walker M. , Li J. , Herrero-Martin J. , Singh G. , Luo Z. , Bhatnagar A. , Chen Y. Z. , Tileli V. , Muralt P. , Kalaboukhov A. , Mertig I. , Dörr K. , Ernst A. , Pryds N. 
Published: July 2020

AbstractComplex oxides show extreme sensitivity to structural distortions and defects, and the intricate balance of competing interactions which emerge at atomically defined interfaces may give rise to unexpected physics. In the interfaces of non-magnetic complex oxides, one of the most intriguing properties is the emergence of magnetism which is sensitive to chemical defects. Particularly, it is unclear which defects are responsible for the emergent magnetic interfaces. Here, we show direct and clear experimental evidence, supported by theoretical explanation, that the B-site cation stoichiometry is crucial for the creation and control of magnetism at the interface between non-magnetic ABO3-perovskite oxides, LaAlO3 and SrTiO3. We find that consecutive defect formation, driven by atomic charge compensation, establishes the formation of robust perpendicular magnetic moments at the interface. Our observations propose a route to tune these emerging magnetoelectric structures, which are strongly coupled at the polar-nonpolar complex oxide interfaces.
Mutations in COMP cause familial carpal tunnel syndrome
Authors: Li Chunyu , Wang Ni , Schäffer Alejandro A. , Liu Xilin , Zhao Zhuo , Elliott Gene , Garrett Lisa , Choi Nga Ting , Wang Yueshu , Wang Yufa , Wang Cheng , Wang Jin , Chan Danny , Su Peiqiang , Cui Shusen , Yang Yingzi , Gao Bo 
Published: July 2020

AbstractCarpal tunnel syndrome (CTS) is the most common peripheral nerve entrapment syndrome, affecting a large proportion of the general population. Genetic susceptibility has been implicated in CTS, but the causative genes remain elusive. Here, we report the identification of two mutations in cartilage oligomeric matrix protein (COMP) that segregate with CTS in two large families with or without multiple epiphyseal dysplasia (MED). Both mutations impair the secretion of COMP by tenocytes, but the mutation associated with MED also perturbs its secretion in chondrocytes. Further functional characterization of the CTS-specific mutation reveals similar histological and molecular changes of tendons/ligaments in patients’ biopsies and the mouse models. The mutant COMP fails to oligomerize properly and is trapped in the ER, resulting in ER stress-induced unfolded protein response and cell death, leading to inflammation, progressive fibrosis and cell composition change in tendons/ligaments. The extracellular matrix (ECM) organization is also altered. Our studies uncover a previously unrecognized mechanism in CTS pathogenesis.
Observation of the geometric phase effect in the H+HD→H2+D reaction below the conical intersection
Authors: Yuan Daofu , Huang Yin , Chen Wentao , Zhao Hailin , Yu Shengrui , Luo Chang , Tan Yuxin , Wang Siwen , Wang Xingan , Sun Zhigang , Yang Xueming 
Published: July 2020

AbstractIt has long been known that there is a conical intersection (CI) between the ground and first excited electronic state in the H3 system. Its associated geometric phase (GP) effect has been theoretically predicted to exist below the CI since a long time. However, the experimental evidence has not been established yet and its dynamical origin is waiting to be elucidated. Here we report a combined crossed molecular beam and quantum reactive scattering dynamics study of the H+HD → H2+D reaction at 2.28 eV, which is well below the CI. The GP effect is clearly identified by the observation of distinct oscillations in the differential cross section around the forward direction. Quantum dynamics theory reveals that the GP effect arises from the phase alteration of a small part of the wave function, which corresponds to an unusual roaming-like abstraction pathway, as revealed by quasi-classical trajectory calculations.
Future changes in the trading of virtual water
Authors: Graham Neal T. , Hejazi Mohamad I. , Kim Son H. , Davies Evan G. R. , Edmonds James A. , Miralles-Wilhelm Fernando 
Published: July 2020

AbstractWater stressed regions rely heavily on the import of water-intensive goods to offset insufficient food production driven by socioeconomic and environmental factors. The water embedded in these traded commodities, virtual water, has received increasing interest in the scientific community. However, comprehensive future projections of virtual water trading remain absent. Here we show, for the first time, changes over the 21st century in the amount of various water types required to meet international agricultural demands. Accounting for evolution in socioeconomic and climatic conditions, we estimate future interregional virtual water trading and find trading of renewable water sources may triple by 2100 while nonrenewable groundwater trading may at least double. Basins in North America, and the La Plata and Nile Rivers are found to contribute extensively to virtual water exports, while much of Africa, India, and the Middle East relies heavily on virtual water imports by the end of the century.