bluuebunny/crossref_metadata_2025_split huggingface dataset:
Explorando diferentes subproductos considerados como residuos por la industria pesquera en México//Exploring different by-products considered as residues by the fishery industry in México
Authors: García-Sifuentes Celia Olivia , Scheuren-Acevedo Susana Maria , Zamorano-Apodaca Julio Cesar 
Published: April 2020

La producción y poco aprovechamiento de subproductos de los grandes centros de distribución en México causa problemas ambientales. Se exploró la composición fisicoquímica de distintos subproductos evaluando el pH, humedad, lípidos, ceniza, proteínas, nitrógeno no proteico, bases volátiles totales, hidroxiprolina y prolina en tres sitios (zonas) de muestreo durante tres meses diferentes, cada zona o sitio representó muestras diferentes, así: MM (mezcla de subproductos de diferentes especies), AT (subproductos derivados del enlatado de atún), TL (subproductos derivados del fileteo de tilapia). Se registraron diferencias en la composición química entre los tres meses de muestreo y entre los tres sitios evaluados. Los resultados mostraron que los componentes más importantes que se pueden recuperar son: proteínas, para el sitio MM, incluyendo el colágeno; lípidos y proteínas, para el sitio AT; colágeno y lípidos para el sitio TL. Los valores promedio de pH (7.89), humedad (72.75 %) y BVT (188 mg N/100 g) para el sitio MM, demuestran la necesidad de mejorar el manejo de los subproductos en ese sitio. Los subproductos de los tres sitios de muestreo mostraron ser una fuente alternativa de componentes importantes como proteínas que no son colágeno, colágeno, lípidos y cenizas, dependiendo del sitio. Sin embargo, es importante resaltar la necesidad de mejorar el manejo de los subproductos para lograr un mayor aprovechamiento.ABSTRACTThe production and under-utilization of by-products from the large distribution centers in México, promotes environmental problems. The physicochemical composition of different by-products produced by the large distribution centers throughout different months was explored evaluating pH, moisture, lipids, ash, proteins, non-protein nitrogen, total volatile bases, hydroxyproline and proline, in three places during three months, each place represented different sample, including: MM (by-products from different fish species), AT (by-products of tuna canning, and TL (tilapia by-products). There were differences in chemical composition among the three months and the evaluated places. Results showed that the most important components that could be recovered are proteins for MM, collagen, lipids and proteins for AT and collagen and lipids for TL. Average values of pH (7.89), moisture (72.75 %) and total volatile bases (188 mg N/100 g) demonstrate the need of improving the by-products management in the MM place. By-products from the three evaluated places showed be an alternative source to obtain important components including non-collagen proteins, collagen, lipids, and ash depending on the sampling place. However, it is important to highlight the need of improving the handling of by-products to achieve greater exploitation.
CORRELAÇÃO ENTRE COMPOSTOS BIOATIVOS E ATIVIDADE ANTIOXIDANTE DE POLPA DE GUAPEVA (Pouteria cf. Guardneriana Radlk)
Authors: Mariane da Silva Soares Camila , Alves Morais Romulo , Ramos da Silva Romilda , Oliveira de Aguiar Aynaran , Leonardo dos Santos André , Ibiapina Andréia , Aparecida de Souza Martins Glêndara 
Published: April 2020

A guapeva (Pouteria cf. Guardneriana Radlk) é um fruto oriundo do cerrado, pouco conhecido, mas que possui alto potencial fenolico, como carotenoides, vitamina C e comprovada atividade antioxidante, que pode contribuir no combate a doenças crônico-degenerativas, tais como câncer e diabetes. Os compostos fenolicos agem de forma antioxidante combatendo os radicais livres reagindo com DNA, RNA, proteínas e outras substâncias oxidáveis. Assim o objetivo desta pesquisa foi verificar as correlações entre os compostos bioativos da polpa de guapeva e os compostos antioxidantes utilizando a Correlação de Pears. Verificou-se que o conteúdo fenólico presente na polpa da guapeva apresentou forte correlação com vitamina C (R=0,99) e carotenóide (R=0,88), demosntrando que esses constituintes contribuem de forma expressiva no potencial fenólico do fruto, e os carotenóides totais correlacionou-se fortemente com as antocianinas e o flavonoide (R=0,97 e R=0,91). Para os resultados entre conteúdo fenólico e o método de FRAP demonstrou correlação considerada moderada (R=0,59) atestando um vínculo estreito entre os compostos fenólicos e FRAP, indicando que a capacidade antioxidante da guapeva tem associação com os seus constituintes fenólicos. Ainda assim o fruto é considerado como um alimento que possui um alto potencial antioxidante natural podendo ser incorporado na dieta humana.
ESTUDO DO PROCESSO DE SECAGEM CONVECTIVA DO PIMENTÃO (Capsicum annuum L.)
Authors: Lima Sousa Edwallas , Souza Silva Djany , Brilhante de Sousa Antonia Mayara , De Araujo Alves Renata , Gonçalves Abreu Virgínia Kelly , Fernandes Pereira Ana Lúcia 
Published: April 2020

O objetivo deste trabalho foi estudar a cinética de secagem do pimentão (Capsicum annuum L.) em estufa com circulação forçada de ar a 80 °C, através de diferentes modelos matemáticos. Para isso, foram utizados pimentões, os quais foram fatiados nas dimensões 3,0 cm de comprimento, 2,5 cm de largura e 0,5 cm de espessura. As fatias foram dispostas em bandejas perfuradas de alumínio. As equações de Lewis, Page, Logarítmica e de Henderson e Pabis foram ajustadas para os dados experimentais e o grau de ajuste foi avaliado mediante o coeficiente de determinação (R²) e erro médio relativo. De acordo com os resultados, observou-se o tempo de secagem de 420 min para peso estável na temperatura de 80 ˚C e atividade de água (Aw) de 0,676. A manutenção de um baixo valor de Aw é essencial para garantir a estabilidade microbiológica do produto. O modelo de Lewis, para a faixa de tempo de secagem entre 0 a 180 min foi o que apresentou melhor ajuste matemático à curva experimental, obtendo o maior R² e menor valor de P. Desta forma, esse modelo apresenta-se com o mais recomendado para a predição do comportamento da secagem do pimentão à 80 °C.
ASPECTOS FÍSICOS E FUNCIONAIS DE UMA UNIDADE DE ALIMENTAÇÃO E NUTRIÇÃO DE UM MUNICÍPIO MARANHENSE
Authors: Lopes Macedo Joyce , Suellenn da Silva Santos Oliveira Amanda , Costa Pereira Irislene , Da Rocha Silva Ferraz Josiane , Sousa Magalhães Assunção Magnólia  de Jesus 
Published: April 2020

RESUMO
Ao passar dos anos as Unidades de Alimentação e Nutrição (UAN) têm crescido significativamente, todavia, muitas apresentam padrões de estruturas físicas e funcionais inadequadas. A pesquisa teve por objetivo analisar a adequação da estrutura física e funcional de uma UAN em um município Maranhense. Estudo descritivo e transversal, utilizando como critério a RDC nº 275 de 2002, para determinar se as condições estruturais e funcionais encontravam-se em situações propícias à obtenção de alimentos seguros. As opções de respostas para o preenchimento do checklist foram: para conforme (C), itens não conforme (NC), para os itens não atendidos, e não se aplica (NA), aos itens observados no estabelecimento avaliado. Verificou-se algumas falhas quanto à estrutura física, aspectos como iluminação, ventilação, pisos e paredes, portas e janelas, bem como instalações elétricas, hidráulicas e de gás apresentaram-se inadequadas, em relação a estrutura funcional, observou-se condições insatisfatórias relacionadas ao destino do lixo, contudo, o controle da potabilidade de água, pragas e vetores estavam adequadas, a referida unidade possui registros, manuais, fichas técnicas e demais formas de controle para a padronização e funcionamento da UAN. Conclui-se que a unidade se encontra em condições inadequadas, indicando a necessidade de mudanças que visem à sua melhoria.
Palavras-chave: Unidade de Alimentação e Nutrição. Estrutura Física. Estrutura Funcional.
SINTOMAS DEPRESSIVOS ENTRE ESTUDANTES DE MEDICINA DE UMA UNIVERSIDADE DA REGIÃO SUL DO TOCANTINS
Authors: Lopes Marinho Vinícius , Da Silva Jeann Bruno Ferreira , Ribeiro Dias Aline 
Published: April 2020

Introdução: A Organização Mundial da Saúde estima que a depressão será considerada a doença mais comum nos próximas 3 décadas. Esse agravo já é visível entre o meio universitário, principalmente entre estudantes dos cursos de medicina das universidades brasileiras. Objetivo: Investigar a existência de sintomas depressivos em estudantes de medicina de uma Universidade da região Sul do Tocantins. Material e Métodos: trata-se de pesquisa de campo, de natureza descritiva de cunho quantitativo. Os dados são apresentados por meio de tabelas e gráficos que expressam escores absolutos em forma de percentuais. A coleta ocorreu em dias distintos do ano de 2019 nas próprias salas de aula, em intervalos cedidos pelos docentes. O instrumento utilizado foi o Inventário de Depressão de Beck-BDI. Resultados e discussão: os dados demográficos apontaram que a maioria dos estudantes, 58%, são do sexo feminino e 42% do sexo masculino. Destes, 69% não apresentam nenhum tipo de sintomatologia enquanto 31% apresentam alguma sintomatologia depressiva. 16% apresenta sintomatologia leve, 12% moderada e 3% grave. Considerações finais: A maioria dos entrevistados não apresentou sintomatologia alguma, no entanto há uma distribuição considerável que apresenta os referidos sintomas e este fato evidenciou que há necessidade de intervenção com a referida população.
Palavras-chave: Sintomas depressivos; Estudantes de medicina; Universidade
ANÁLISE DO SOLO, DA ÁGUA E DE PRODUTOS DO COTIDIANO COMO FERRAMENTA PARA O ENSINO DE ÁCIDOS E BASES
Authors: Yamaguchi Klenicy , Castro Elias Ferreira 
Published: April 2020

A química está presente no dia-a-dia e utilizar materiais conhecidos pelos discentes torna-se uma ferramenta importante para facilitar o processo de aprendizagem significativa dos discentes. O objetivo desta pesquisa foi realizar a análise o pH do solo, da água de um igarapé e de materiais comuns do cotidiano doméstico como atividade experimental do conteúdo de ácido-base para discentes do terceiro ano do ensino Médio de uma escola pública no município de Coari, Amazonas, Brasil. Para tanto, utilizou-se indicador natural de repolho roxo e indicador de papel, classificando os materiais em ácido, base e neutros. A atividade realizada teve a participação e interesse dos discentes, sendo uma alternativa simples e de baixo custo para explicar o conteúdo de ácido-base nas aulas de química, tornando o aprendizado mais significativo.
Geospatial Mapping of Orthopaedic Surgeons Age 60 and Over and Confirmed Cases of COVID-19
Authors: Jella Tarun K. , Acuña Alexander J. , Samuel Linsen T. , Jella Taral K. , Mroz Thomas E. , Kamath Atul F. 
Published: April 2020

Background:
Although elective surgical procedures in the United States have been suspended because of the coronavirus disease 2019 (COVID-19) pandemic, orthopaedic surgeons are being recruited to serve patients with COVID-19 in addition to providing orthopaedic acute care. Older individuals are deemed to be at higher risk for poor outcomes with COVID-19. Although previous studies have shown a high proportion of older providers nationwide across medical specialties, we are not aware of any previous study that has analyzed the age distribution among the orthopaedic workforce. Therefore, the purposes of the present study were (1) to determine the geographic distribution of U.S. orthopaedic surgeons by age, (2) to compare the distribution with other surgical specialties, and (3) to compare this distribution with the spread of COVID-19.

Methods:
Demographic statistics from the most recent State Physician Workforce Data Reports published by the Association of American Medical Colleges were extracted to identify the 2018 statewide proportion of practicing orthopaedic surgeons ≥60 years of age as well as age-related demographic data for all surgical specialties. Geospatial data on the distribution of COVID-19 cases were obtained from the Environmental Systems Research Institute. State boundary files were taken from the U.S. Census Bureau. Orthopaedic workforce age data were utilized to group states into quintiles.

Results:
States with the highest quintile of orthopaedic surgeons ≥60 years of age included states most severely affected by COVID-19: New York, New Jersey, California, and Florida. For all states, the median number of providers ≥60 years of age was 105.5 (interquartile range [IQR], 45.5 to 182.5). The median proportion of orthopaedic surgeons ≥60 years of age was higher than that of all other surgical subspecialties, apart from thoracic surgery.

Conclusions:
To our knowledge, the present report provides the first age-focused view of the orthopaedic workforce during the COVID-19 pandemic. States in the highest quintile of orthopaedic surgeons ≥60 years old are also among the most overwhelmed by COVID-19. As important orthopaedic acute care continues in addition to COVID-19 frontline service, special considerations may be needed for at-risk staff. Appropriate health system measures and workforce-management strategies should protect the subset of those who are most potentially vulnerable.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Telemedicine in the Era of COVID-19
Authors: Tanaka Miho J. , Oh Luke S. , Martin Scott D. , Berkson Eric M. 
Published: April 2020

Abstract:

Update
This article was updated on September 18, 2020, because of a previous error. On page 3, the legend for Figure 2 that had read “External rotation of the hip can be measured by having the patient sit in a chair facing the camera and rotating the hip with the knee bent at 90°” now reads “Rotation of the hip can be measured by having the patient sit in a chair facing the camera and rotating the hip with the knee bent at 90°.”
An erratum has been published: J Bone Joint Surg Am. 2020 Oct 21;102(20):e121.
With the onset of the COVID-19 pandemic, the shifting of clinical care to telemedicine visits has been hastened. Because of current limitations in resources, many elective surgeons have been forced to venture into utilizing telemedicine, in which the standards for orthopaedic examinations have not previously been fully developed. We report our experience with protocols and methods to standardize these visits to maximize the benefit and efficiency of the virtual orthopaedic examination. At the time of scheduling, patients are asked to prepare for their virtual visit and are given a checklist. In addition to confirming audiovisual capabilities prior to the visit, patients are given specific instructions on camera positioning, body positioning, setting, and attire to improve the efficiency of the visit. During the examination, digital tools can be utilized as needed. In the setting of outpatient injury evaluations, a systematic virtual examination can aid in triaging and managing common musculoskeletal conditions. With the rapid incorporation of telehealth visits, as well as the unknown future with regard to the pandemic, the utilization and capabilities of telemedicine will continue to expand. Future directions include the development of validated, modified examination techniques and new technology that will allow for improved interactive physical examinations, as we rapidly move forward into the realm of telemedicine due to unexpected necessity.
Endovascular Balloon Occlusion: An Adjunct to Hemostasis for Above-Knee Amputation After Recalcitrant Chronic Prosthetic Joint Infection of Knee in a Morbidly Obese Patient
Authors: Kahan Joseph , Orion Kristine , Ibe Izuchukwu , Leslie Michael 
Published: April 2020

Case:
A 72-year-old morbidly obese nonambulatory woman with bilateral chronically infected revision knee prostheses and incompetent extensor mechanisms who uses a wheelchair had limited functionality and presented with recalcitrant chronic infection with multiple hospitalizations. The patient underwent staged bilateral above-knee amputations. The first procedure caused extensive morbidity secondary to poor vascular control. For the second surgery, collaboration with vascular surgery was used to achieve endovascular control of the external iliac artery with improved postoperative course.

Conclusions:
Endovascular balloon occlusion may be an effective adjunct to customary hemostasis modalities during above-knee amputations in morbidly obese patients.
Oncogenic miR-20b-5p contributes malignant behavior via bidirectionally regulating CCND1 and E2F1 in breast cancer stem cells
Authors: xia liqin , li feng , qiu jun , feng zhongming , xu zihan , chen zhengtang , Sun Jian-Guo 
Published: April 2020

Abstract
Background Breast cancer is the leading cause of cancer mortality in women worldwide. Therefore, it is of great significance to identify the biological mechanism of tumorigenesis and explore the development of breast cancer to achieve a better prognosis for individuals suffering from breast cancer. MicroRNAs (miRNAs) have become a hot topic in cancer research, but the underlying mechanism remains unclear.Methods The miRNA profile between breast cancer stem cells (BCSCs, CD44+CD24−/low) and control MCF-7 breast cancer cells was obtained in a previous study. Based on biological analysis, miR-20b-5p was hypothesized to be a key factor due to the malignant behavior of BCSCs. Then, agomir-20b-5p and antagomir-20b-5p were transfected into MCF-7 and T47D breast cancer cells to detect cell migration, wound healing and proliferation, and lentivirus vectors silencing or overexpressing miR-20b-5p were transfected into T47D-CSCs to detect proliferation and apoptosis. The effect of miR-20b-5p on xenograft growth was investigated in vivo by transfection of a lentivirus overexpression vector in T47D cells. The target genes were predicted by the online programs picTar, miRanda and TargetScan and verified by dual luciferase assay, and changes in protein expression were detected by western blot.Results miR-20b-5p had the highest degree in both the miRNA-gene network and miRNA-GO network to regulate BCSCs. Overexpression of miR-20b-5p significantly promoted the migration and wound healing ability of MCF-7 cells and T47D cells compared with the control (P < 0.05). In addition, miR-20b-5p facilitated the proliferation of MCF-7 cells and T47D-CSCs (P < 0.05) and inhibited the apoptosis of T47D-CSCs (P < 0.05). Moreover, miR-20b-5p promoted xenograft growth compared with the control group (P < 0.05). Accordingly, potential targets of both CCND1 and E2F1 were predicted by bioinformatics analysis. miR-20b-5p directly targeted both CCND1 and E2F1 in a dual luciferase assay, while antagomir-20b-5p downregulated the protein levels of CCND1 and E2F1.Conclusions Oncogenic miR-20b-5p was confirmed to promote the malignant behavior of breast cancer cells and stem cells. The underlying mechanism lies in miR-20b-5p overall enhanced both CCND1 and E2F1 targets via bidirectional regulation probably involving direct downregulation and indirect upregulation.
Current issues in protocol registration for systematic review and meta-analysis studies: a survey of global researchers
Authors: Tawfik Gehad Mohamed , Giang Hoang Thi Nam , Ghozy Sherief , Altibi Ahmed M. , Kandil Hend , Le Huu-Hoai , Eid Peter Samuel , Radwan Ibrahim , Makram Omar Mohamed , Hien Tong Thi Thu , Sherif Mahmoud , Hossain As-Saba , Thang Tai Luu Lam , Puljak Livia , Salem Hosni , Numair Tarek , Moji Kazuhiko , Huy Nguyen Tien 
Published: April 2020

Abstract
Background Although protocol registration of systematic reviews/meta-analysis (SR/MA) is still not mandatory, authors are strongly suggested to publish their SR/MA protocols prior to submitting their manuscripts for publication as recommended by the Cochrane guidelines for conducting SR/MAs. We aimed to assess awareness, obstacles, and opinions of SR/MA authors about the protocol registration process.Methods A cross-sectional survey study included all authors who published SR/MAs during the period from 2010 to 2016 were contacted for participation in our survey study. They were identified through the literature search of SR/MAs in Scopus database. Upon receiving their approval to join our study, an online questionnaire was sent via e-mail to each participant.Results A total of 270 authors' responses were complete and were included in the final analysis. Our results showed that PROSPERO was the most commonly used database for protocol registration (71.3%). The registration-to-acceptance interval in PROSPERO was less than one month (99.1%). Almost half of the authors (44.2%) did not register their protocols prior to publishing their SR/MAs and their lack of knowledge of its importance was the most commonly reported reason (44.9%). A significant proportion of respondents (37.4%) believed that people would steal their ideas from protocol databases, while only 5.3% reported that their SR/MA had been stolen. However, the majority (72.9%) of participants agreed that protocol registries have a role in preventing unnecessary duplication of reviews. Finally, 37.4% of participants agreed that SR/MA protocol registration should be mandatory.Conclusion Lack of knowledge about SR/MA protocol registration process seems to be the primary reason for not registering such protocols. Therefore, interventions for increasing awareness about the benefits of protocol registration among researchers would be welcome.
Current Methods For Development Of Rapid Reviews About Diagnostic Tests: An International Survey
Authors: Arevalo-Rodriguez Ingrid , Steingart Karen R. , Tricco Andrea C. , Nussbaumer-Streit Barbara , Kaunelis David , Alonso-Coello Pablo , Baxter Susan , Bossuyt Patrick M. , Emparanza José Ignacio , Zamora Javier 
Published: April 2020

Abstract
BACKGROUND Rapid reviews (RRs) have emerged as an efficient alternative to time-consuming systematic reviews—they can help meet the demand for accelerated evidence synthesis to inform decision-making in healthcare. The synthesis of diagnostic evidence has important methodological challenges. Here, we performed an international survey to identify the current practice of producing RRs for diagnostic tests.METHODS We developed and administered an online survey inviting institutions that perform RRs of diagnostic tests from all over the world.RESULTS All participants (N = 25) reported the implementation of one or more methods to define the scope of the RR; however, only one strategy (defining a structured question) was used by ≥ 90% of participants. All participants used at least one methodological shortcut including the use of a previous review as a starting point (92%) and the use of limits on the search (96%). Parallelization and automation of review tasks were not extensively used (48% and 20%, respectively).CONCLUSION Our survey indicates a greater use of shortcuts and limits for conducting diagnostic test RRs versus the results of a recent scoping review analyzing published RRs. Several shortcuts are used without knowing how their implementation affects the results of the evidence synthesis in the setting of diagnostic test reviews. Thus, a structured evaluation of the challenges and implications of the adoption of these RR methods is warranted.