bluuebunny/crossref_metadata_2025_split huggingface dataset:
Noise cancellation of white pulsed light with pulse-to-pulse observation of probe and reference pulses in spectral pump/probe measurement
Authors: Seto Keisuke , Kobayashi Takayoshi , Tokunaga Eiji 
Published: December 2020

Abstract
In pump/probe spectroscopy employing supercontinuum (SC) probe light (Pr), multi-wavelength information is provided at the same time. The SC probe generated by a photonic crystal fiber is advantageous owing to the broad spectrum and synchronized timings of the SC Pr pulse and pump pulse. However, SC light accompanies formidable wavelength dependent noise due to the various contributions of generation mechanisms. We previously developed two noise cancellation methodologies suitable for multiwavelength measurements with SC light, that is, phase detection noise cancellation (PDNC) and time division noise cancellation (TDNC), where the pulse timings for Pr and reference (Rf) are time-shifted and detected by a single photodiode (PD) after passing through the common optical system, providing an identical spectral dispersion to conserve the wavelength-dependent noise correlation. In PDNC, Pr and Rf are discriminated based on the pulse repetition phase, and the Pr is then divided by Rf, whereas in TDNC they are distinguished by the detection time, and Rf is subtracted from Pr. However, a shot noise limited performance with high-power input has yet to be realized. In this study, the deterioration mechanisms for PDNC and TDNC are investigated. The nonlinear effect of the photodetector was found to have a non-negligible impact on the phase noise and intensity noise correlation between Pr and Rf. Adequate decay of the photocurrent of Pr at the detection of the Rf optical pulse is effective for avoiding nonlinearity and maintaining the noise correlation of Pr and Rf for the best noise cancellation. Based on this fact, a near-shot-noise-limited performance is demonstrated by the TDNC, where the Rf optical pulse is incident on the PD after sufficient relaxation of the Pr photocurrent. In addition, the coincidence of the timing of Pr and Rf for the noise subtraction was found to be essential for wideband noise cancellation.
Solving Klein’s paradox
Authors: Wang Huai-Yu 
Published: December 2020

Abstract
We figure out the famous Klein’s paradox arising from the reflection problem when a Dirac particle encounters a step potential with infinite width. The key is to piecewise solve Dirac equation in such a way that in the region where the particle’s energy E is greater (less) than the potential V, the solution of the positive (negative) energy branch is adopted. In the case of Klein–Gordon equation with a piecewise constant potential, the equation is decoupled to positive and negative energy equations, and reflection problem is solved in the same way. Both infinitely and finitely wide potentials are considered. The reflection coefficient never exceeds 1. The results are applied to discuss the transmissions of particles with no mass or with very small mass.
Sigmoidal inflation
Authors: Díaz E , Meza-Aldama O 
Published: December 2020

Abstract
In this paper we present a new cosmological inflationary model which is constructed using the Ivanov-Salopek-Bond method with a logistic generating function. We derive the inflationary observables as well as the duration and temperature of the subsequent reheating epoch of our model exactly, with no need to recur to the slow roll approximation. The obtained scalar spectral index and tensor-to-scalar ratio of perturbations fall comfortably within the range of the measurements presented by the Planck collaboration. On the other hand, for the reheating era, our model predicts a relatively small number of e-folds and thus high temperatures, still within range of Planck’s bounds. We then consider a generalization of our model that we refer to as Bernoulli-like functions and examine different scenarios that are encompassed within this generalization.
Relationships between coworking spaces and CO2 emissions in work-related commuting: first empirical insights for the case of Switzerland with regard to urban-rural differences
Authors: Ohnmacht Timo , Z’Rotz Jana , Dang Lisa 
Published: December 2020

Abstract
Today in transport policy it is assumed that new forms of work are producing falls in greenhouse gas (GHG) emissions from work-related commuting. So far, research on the effects of teleworking generally report positive environmental outcomes. However, no study has so far compared and contrasted the greenhouse gas (GHG) mitigation potential of the new phenomenon of coworking spaces with regard to urban-rural differences. Our results based on a representative sample of Swiss coworkers indicate that CO2 emissions from commuting for work are significantly lower for urban coworking spaces (350 kilograms/year) than for rural coworking spaces (940 kilograms/year). If coworkers only would have worked in their coworking spaces, there would be a 10% reduction in CO2 emissions of their commutes. Overall, our results indicate that coworking spaces, especially in urban areas, have the potential to support Switzerland’s commitment to reduce greenhouse gas (GHG) emissions in the transport sector in line with the Paris Climate Agreement.
Meta-analysis: Higher Plant Richness Supports Higher Pollinator Richness Across Many Land Use Types
Authors: Kral-O’Brien Katherine C , O’Brien Peter L , Hovick Torre J , Harmon Jason P 
Published: December 2020

AbstractGlobal biodiversity declines are attributed to many factors, including landscape fragmentation and vegetation homogenization. These patterns may be exacerbated by the intensification of management in agroecosystems, as management to meet the increasing demand for food, fuel, and fiber often comes at the cost of biodiversity and subsequent ecosystem functions and services. Conserving biodiversity will be necessary to create sustainable agroecosystems capable of optimizing both production and services such as pollination. We conducted a meta-analysis with 109 studies to examine the relationship between plant species richness and pollinator species richness to determine whether higher plant species richness supports higher pollinator species richness, especially in areas prone to biodiversity losses. We found most groups of insect pollinators, including bees, butterflies, flies, moths, and wasps, responded positively to increasing plant species richness, irrespective of location or land use, suggesting the capacity to increase pollinator richness through management strategies that increase plant species richness. However, we found pollinators in manipulated studies did not consistently respond to increasing plant species richness despite the overall positive relationships in observational and experimental studies, highlighting the importance of plant selection when making management decisions aiming to improve pollinator richness. Additional studies in regions such as Africa and South America will help fill in latitudinal gradients and provide greater coverage necessary to refine patterns. Increasing plant species richness through management changes or restorations will likely increase pollinator richness and be beneficial in agroecosystems to support biodiversity.
The effectiveness and cost-effectiveness of assistive technology and telecare for independent living in dementia: a randomised controlled trial
Authors: Howard Robert , Gathercole Rebecca , Bradley Rosie , Harper Emma , Davis Lucy , Pank Lynn , Lam Natalie , Talbot Emma , Hooper Emma , Winson Rachel , Scutt Bethany , Ordonez Montano Victoria , Nunn Samantha , Lavelle Grace , Bateman Andrew , Bentham Peter , Burns Alistair , Dunk Barbara , Forsyth Kirsty , Fox Chris , Poland Fiona , Leroi Iracema , Newman Stanton , O’Brien John , Henderson Catherine , Knapp Martin , Woolham John , Gray Richard 
Published: December 2020

Abstract

Objectives
The use of assistive technology and telecare (ATT) has been promoted to manage risks associated with independent living in people with dementia but with little evidence for effectiveness.

Methods
Participants were randomly assigned to receive an ATT assessment followed by installation of all appropriate ATT devices or limited control of appropriate ATT. The primary outcomes were time to institutionalisation and cost-effectiveness. Key secondary outcomes were number of incidents involving risks to safety, burden and stress in family caregivers and quality of life.

Results
Participants were assigned to receive full ATT (248 participants) or the limited control (247 participants). After adjusting for baseline imbalance of activities of daily living score, HR for median pre-institutionalisation survival was 0.84; 95% CI, 0.63 to 1.12; P = 0.20. There were no significant differences between arms in health and social care (mean -£909; 95% CI, -£5,336 to £3,345, P = 0.678) and societal costs (mean -£3,545; 95% CI, -£13,914 to £6,581, P = 0.499). ATT group members had reduced participant-rated quality-adjusted life years (QALYs) at 104 weeks (mean − 0.105; 95% CI, −0.204 to −0.007, P = 0.037) but did not differ in QALYs derived from proxy-reported EQ-5D.

Discussion
Fidelity of the intervention was low in terms of matching ATT assessment, recommendations and installation. This, however, reflects current practice within adult social care in England.

Conclusions
Time living independently outside a care home was not significantly longer in participants who received full ATT and ATT was not cost-effective. Participants with full ATT attained fewer QALYs based on participant-reported EQ-5D than controls at 104 weeks.
Hypertension in Chronic Kidney Disease (CKD): Diagnosis, Classification, and Therapeutic Targets
Authors: Georgianos Panagiotis I , Agarwal Rajiv 
Published: December 2020

Abstract
Blood pressure (BP) in the office is often recorded without standardization of the technique of measurement. When office BP measurement is performed with a research-grade methodology, it can inform better therapeutic decisions. The reference-standard method of ambulatory BP monitoring (ABPM) together with the assessment of BP in the office enables the identification of white-coat and masked hypertension, facilitating the stratification of cardiorenal risk. Compared with general population, the prevalence of resistant hypertension is 2- to 3-fold higher among patients with chronic kidney disease (CKD). The use of ABPM is mandatory in order to exclude the white-coat effect, a common cause of pseudoresistance, and confirm the diagnosis of true-resistant hypertension. After the premature termination of Systolic Blood Pressure Intervention Trial due to an impressive cardioprotective benefit of intensive BP-lowering, the 2017 American Heart Association/American College of Cardiology guideline reappraised the definition of hypertension and recommended a tighter BP target of &lt;130/80 mm Hg for the majority of adults with a high cardiovascular risk profile, inclusive of patients with CKD. However, the benefit/risk ratio of intensive BP-lowering in particular subsets of patients with CKD (i.e., those with diabetes or more advanced CKD) continues to be debated. We explore the controversial issue of BP targets in CKD, providing a critical evaluation of the available clinical-trial evidence and guideline recommendations. We argue that the systolic BP target in CKD, if BP is measured correctly, should be &lt;120 mm Hg.
C-Reactive Protein and Incident Hypertension in Black and White Americans in the REasons for Geographic And Racial Differences in Stroke (REGARDS) Cohort Study
Authors: Plante Timothy B , Long D Leann , Guo Boyi , Howard George , Carson April P , Howard Virginia J , Judd Suzanne E , Jenny Nancy Swords , Zakai Neil A , Cushman Mary 
Published: December 2020

Abstract

Background
More inflammation is associated with greater risk incident hypertension, and Black United States (US) adults have excess burden of hypertension. We investigated whether increased inflammation as quantified by higher C-reactive protein (CRP) explains the excess incidence in hypertension experienced by Black US adults.

Methods
We included 6,548 Black and White REasons for Geographic and Racial Differences in Stroke (REGARDS) participants without hypertension at baseline (2003–2007) who attended a second visit (2013–2016). Sex-stratified risk ratios (RRs) for incident hypertension at the second exam in Black compared to White individuals were estimated using Poisson regression adjusted for groups of factors known to partially explain the Black–White differences in incident hypertension. We calculated the percent mediation by CRP of the racial difference in hypertension.

Results
Baseline CRP was higher in Black participants. The Black–White RR for incident hypertension in the minimally adjusted model was 1.33 (95% confidence interval 1.22, 1.44) for males and 1.15 (1.04, 1.27) for females. CRP mediated 6.6% (95% confidence interval 2.7, 11.3%) of this association in females and 19.7% (9.8, 33.2%) in males. In females, CRP no longer mediated the Black–White RR in a model including waist circumference and body mass index, while in males the Black–White difference was fully attenuated in models including income, education and dietary patterns.

Conclusions
Elevated CRP attenuated a portion of the unadjusted excess risk of hypertension in Black adults, but this excess risk was attenuated when controlling for measures of obesity in females and diet and socioeconomic factors in males. Inflammation related to these risk factors might explain part of the Black–White disparity in hypertension.
The fine-grainedness of poetry: A new argument against the received view
Authors: Glavaničová Daniela , Kosterec Miloš 
Published: December 2020

Abstract
This paper formulates a new argument against the received view in the philosophy of poetry. The received view consists of three tenets: the unity of poetic form and poetic content; the impossibility of paraphrasing and translating poetry; and the hyperintensionality of poetry. We will explore the same detour via direct quotation that has been used by proponents of the received view. We will argue that the hyperintensionality and unity of quotation do not guarantee its untranslatability, and thus that the inference of untranslatability from hyperintensionality and unity is not universally valid. As a consequence, the claim that poetry cannot be translated is left without much support, since it relies on the same kind of inference. However, this does not mean that poetry is translatable; it means only that if it is not translatable, this is due to something other than the combination of hyperintensionality and unity.
Physiological costs and age constraints of a sexual ornament: an experimental study in a wild bird
Authors: McQueen Alexandra , Delhey Kaspar , Szecsenyi Beatrice , Crino Ondi L , Roast Michael J , Peters Anne 
Published: December 2020

Abstract
Sexual ornaments are often considered honest signals of quality because potential costs or constraints prevent their display by low-quality individuals. Testing for potential physiological costs of ornaments is difficult, as this requires experimentally forcing individuals to produce and display elaborate ornaments. We use this approach to test whether a sexually selected trait is physiologically costly to male superb fairy-wrens (Malurus cyaneus). Male fairy-wrens molt from brown to blue breeding plumage at different times of the year, and females strongly prefer the few males that are blue early, during winter. We used short-acting testosterone implants to stimulate males to produce “early-blue” plumage and assessed costs during and after molt using a panel of physiological indices. Testosterone-implanted, T-males molted in winter and produced blue plumage 6 weeks before control-implanted, C-males. T-males molted while in lower body condition, tended to have lower fat reserves, and were more likely to be parasitized by lice. However, we detected no negative effects on immune function, blood parasites, exposure to stressors, or survival. Juvenile males never naturally display early-blue plumage, but we found no evidence for increased costs paid by juvenile T-males. Instead, juvenile T-males molted later than adult T-males, suggesting that age presents an absolute constraint on ornament exaggeration that cannot be fully overcome by testosterone treatment. Together, these small costs and large, age-related constraints may enforce signal honesty, and explain female preference for early-blue males.
Aerial attack strategies of hawks hunting bats, and the adaptive benefits of swarming
Authors: Brighton Caroline H , Zusi Lillias , McGowan Kathryn A , Kinniry Morgan , Kloepper Laura N , Taylor Graham K 
Published: December 2020

Abstract
Aggregation can reduce an individual’s predation risk, by decreasing predator hunting efficiency or displacing predation onto others. Here, we explore how the behaviors of predator and prey influence catch success and predation risk in Swainson’s hawks Buteo swainsoni attacking swarming Brazilian free-tailed bats Tadarida brasiliensis on emergence. Lone bats including stragglers have a high relative risk of predation, representing ~5% of the catch but ~0.2% of the population. Attacks on the column were no less successful than attacks on lone bats, so hunting efficiency is not decreased by group vigilance or confusion. Instead, lone bats were attacked disproportionately often, representing ~10% of all attacks. Swarming therefore displaces the burden of predation onto bats outside the column—whether as isolated wanderers not benefitting from dilution through attack abatement, or as peripheral stragglers suffering marginal predation and possible selfish herd effects. In contrast, the hawks’ catch success depended only on the attack maneuvers that they employed, with the odds of success being more than trebled in attacks involving a high-speed stoop or rolling grab. Most attacks involved one of these two maneuvers, which therefore represent alternative rather than complementary tactics. Hence, whereas a bat’s survival depends on maintaining column formation, a hawk’s success does not depend on attacking lone bats—even though their tendency to do so is sufficient to explain the adaptive benefits of their prey’s aggregation behavior. A hawk’s success instead depends on the flight maneuvers it deploys, including the high-speed stoop that is characteristic of many raptors.
Swarming bats emerging from a massive desert roost reduce their predation risk by maintaining tight column formation, because the hawks that predate them attack peripheral stragglers and isolated wanderers disproportionately. Whereas a bat’s predation risk depends on maintaining its position within the column, the catch success of a hawk depends on how it maneuvers itself to attack, and is maximized by executing a high-speed dive or rolling grab maneuver.
VINYL: Variant prIoritizatioN bY survivaL analysis
Authors: Chiara Matteo , Mandreoli Pietro , Tangaro Marco Antonio , D’Erchia Anna Maria , Sorrentino Sandro , Forleo Cinzia , Horner David S , Zambelli Federico , Pesole Graziano 
Published: December 2020

Abstract

Motivation
Clinical applications of genome re-sequencing technologies typically generate large amounts of data that need to be carefully annotated and interpreted to identify genetic variants potentially associated with pathological conditions. In this context, accurate and reproducible methods for the functional annotation and prioritization of genetic variants are of fundamental importance.

Results
In this article, we present VINYL, a flexible and fully automated system for the functional annotation and prioritization of genetic variants. Extensive analyses of both real and simulated datasets suggest that VINYL can identify clinically relevant genetic variants in a more accurate manner compared to equivalent state of the art methods, allowing a more rapid and effective prioritization of genetic variants in different experimental settings. As such we believe that VINYL can establish itself as a valuable tool to assist healthcare operators and researchers in clinical genomics investigations.

Availability and implementation
VINYL is available at http://beaconlab.it/VINYL and https://github.com/matteo14c/VINYL.

Supplementary information
Supplementary data are available at Bioinformatics online.
Jagged Ends of Urinary Cell-Free DNA: Characterization and Feasibility Assessment in Bladder Cancer Detection
Authors: Zhou Ze , Cheng Suk Hang , Ding Spencer C , Heung Macy M S , Xie Tingting , Cheng Timothy H T , Lam W K Jacky , Peng Wenlei , Teoh Jeremy Y C , Chiu Peter K F , Ng Chi-Fai , Jiang Peiyong , Chan K C Allen , Chiu Rossa W K , Lo Y M Dennis 
Published: December 2020

AbstractBackgroundDouble-stranded DNA in plasma is known to carry single-stranded ends, called jagged ends. Plasma DNA jagged ends are biomarkers for pathophysiologic states such as pregnancy and cancer. It remains unknown whether urinary cell-free DNA (cfDNA) molecules have jagged ends.MethodsJagged ends of cfDNA were detected by incorporating unmethylated cytosines during a DNA end-repair process, followed by bisulfite sequencing. Incorporation of unmethylated cytosines during the repair of the jagged ends lowered the apparent methylation levels measured by bisulfite sequencing and were used to calculate a jagged end index. This approach is called jagged end analysis by sequencing.ResultsThe jagged end index of urinary cfDNA was higher than that of plasma DNA. The jagged end index profile of plasma DNA displayed several strongly oscillating major peaks at intervals of approximately 165 bp (i.e., nucleosome size) and weakly oscillating minor peaks with periodicities of approximately 10 bp. In contrast, the urinary DNA jagged end index profile showed weakly oscillating major peaks but strongly oscillating minor peaks. The jagged end index was generally higher in nucleosomal linker DNA regions. Patients with bladder cancer (n = 46) had lower jagged end indexed of urinary DNA than participants without bladder cancer (n = 39). The area under the curve for differentiating between patients with and without bladder cancer was 0.83.ConclusionsJagged ends represent a property of urinary cfDNA. The generation of jagged ends might be related to nucleosomal structures, with enrichment in linker DNA regions. Jagged ends of urinary DNA could potentially serve as a new biomarker for bladder cancer detection.
An exceptionally giant left atrial myxoma: a case report and literature review
Authors: Al-Zamkan Bassil Khalil , Hashem Anas Mohamad , Alaaeldin Samir Ahmed , Abdel Aziz Mohamed 
Published: December 2020

Abstract

Background
Cardiac myxomas are considered the most common benign heart tumours. The clinical manifestations mainly depend on the size of the tumour. They usually vary from asymptomatic, mild non-specific symptoms, to severe obstructive cardiac and systemic findings. We describe herein a significantly large left atrial myxoma in a patient misdiagnosed with respiratory asthma.

Case summary
A 54-year-old lady, was diagnosed previously with asthma, presented with a history of dyspnoea on exertion, palpitations, and mild peripheral oedema. Chest X-ray suggested pulmonary congestion. Due to high suspicion of cardiac issues, transthoracic echocardiography was done revealing giant left atrial mass. Consequently, the mass was approached and excised surgically through the inverted T biatrial incision. Grossly, the mass measured 10 × 8 × 6 cm, and it had a smooth surface and was filled with gelatinous material. The histopathology confirmed benign myxoma without malignant features.

Discussion
Our article mainly focuses on the diagnostic challenges of a patient with atrial myxoma. The major discrepancy between the tumour size and the severity of the patient’s symptoms should draw physicians’ attention to consider atrial myxoma over a long list of differentials, in order to take immediate action to reduce the mortality and improve the overall prognosis.