P1109HDX: IS IT A BETTER WAY TO DIALYSE?
Authors: Anwar Nageen , Naz Noshaba , Reynolds Anna , Chumber Ruby 
Published: June 2020

Abstract

Background and Aims
Inadequate dialysis has been linked to reduced quality of life, increased symptom burden and increased risk of cardiovascular illness in patients with chronic kidney disease. This is especially significant in long-term haemodialysis patients who have little to no residual urine output and are thus almost entirely dependent on good quality dialysis to remove toxins and fluid.
In most conventional haemodialysis modes middle molecule clearance is inadequate. This in turn plays an important part in causing multiple complications.
HDx is a new type of haemodialysis being introduced using Theranova® dialyzer. This claims to have medium cut-off membranes, functioning similar to a kidney, hence providing better clearance of middle molecules, whilst selectively preventing loss of proteins from the body.
In order to test the safety and efficacy of HDx using Theranova® we tried it in a cohort of our patients in the form of an audit.
Our primary objective was to find out the effect of HDx on quality of life.
Secondary objective was to determine whether HDx improves blood biochemistry, with a reduction in medication & transfusion needs.

Method
Thirty seven Haemodialysis patients were switched from hemodiafiltration to HDx, out of these 3 patients were transplanted, 2 patients died, 1 patient switched back and 7 patients were transferred to satellite units. Audit was continued with the remaining 24 patients.
All patients completed an Integrated Palliative Care Outcome Score (IPOS) prior to commencing on HDx and then at six months.
Blood parameters including phosphorous, calcium, haemoglobin, Ferritin and CRP were measured monthly and mean values of 6 months before and after HDx initiation were compared.
Comparison of erythropoietin, intravenous iron and packed red blood cell transfusion requirements pre and post HDx commencement were also undertaken.

Results
No obvious adverse effects were noted with use of HDx dialysis.
All patients had an improvement in overall IPOS scores after being on HDx for 6 months. Shorter post dialysis symptom recovery times were also noted.
13 patients had a decrease in their erythropoietin requirements, in 2 patients requirement remained the same, 9 patients had increase in their requirement however 3 of these patients had been requiring packed red blood cell transfusion prior to HDx commencement, no longer required transfusion.
We found an overall improvement in patients iron infusion need. 11 patients had a dose reduction, with 4 of these patients no longer requiring iron. 9 patients continued to have the same requirements. 4 patients had an increase in iron dose, but 3 of these patients previously being transfusion dependant no longer required regular transfusions.
We also noted that with use of HDx clotting risk was reduced and patients who were switched from Evodial (heparin coated dialyzer membranes) to HDx did not have increased circuit clotting.
With regards to inflammation we noted no significant changes in CRP, ferritin levels and other blood parameters.

Conclusion
Looking at our cohort of patients we concluded that HDx is safe to use with no obvious adverse effects.
It seems that use of HDx is particularly helpful in improving quality of life in dialysis patients as indicated by improvement in IPOS scores. IPOS is a validated questionnaire to measure symptoms and concerns in patients with advanced illnesses. As life quality is a major concern in dialysis patients, this outcome is of particular significance.
HDx was also helpful in reducing the overall burden of transfusions, iron and erythropoietin requirements. This is beneficial in overall patient health and cost burden.
Based on the above we found out that HDX was safe and effective in our patient cohort, however large-scale studies will be required for more conclusive evidence.