bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Potential Key Genes Associated with the Pathogenesis and Prognosis of Glioblastoma Based on Integrated Bioinformatics Analysis
Authors: Tu Youbing , Zhou Sijia , Zhang Hui , Lv Jing , Ding Dengfeng , Zhang Zhongjun 
Published: April 2020

Abstract
Background: Despite striking advances in multimodality management, the low survival rate of Glioblastoma (GBM) patients has not been significantly improved and identifying novel diagnostic and prognostic biomarkers is urgently demanded. The present study aimed to identify potential key genes associated with the pathogenesis and prognosis of GBM.Methods: Differentially expressed genes between GBM and normal brain tissue samples were screened by an integrated analysis of multiple gene expression profile datasets. Key genes related to the pathogenesis and prognosis of GBM were identified by employing protein–protein interaction network and Cox proportional hazards model analyses.Results: We identified nine hub genes (TP53, FN1, EGFR, MYC, RRM2, EZH2, FOXM1, CD44 and MMP2) which might be closely associated with the pathogenesis of GBM. A prognostic gene signature consisted of RAB33B, KIAA1199, TEK, EVC, SOD2, CXCR4, hCG_40738, CHD9, GCSH, SUHW1, RPS6KA5, PDCD4, ZG16, KCNG1, DECR1, PPCS, SERPINF1, TMSB10, NAT10, HIC2, PIR and OR2W1 was constructed with a good performance in predicting overall survivals (OS).Conclusions: The findings of present study would provide certain reference for further predicting the diagnostic and prognostic biomarkers to facilitate the molecular targeting therapy of GBM.
Prognostic Value of Circulating Tumour Cells detected with the CellSearch System in Esophageal Cancer Patients: A Systematic Review and Meta-Analysis
Authors: Li Yiding , Wu Guiling , Yang Wanli , Wang Xiaoqian , Duan Lili , Niu Liaoran , Zhang Yujie , Liu Jinqiang , Hong Liu , Fan Daiming 
Published: April 2020

Abstract
Background: Esophageal carcinoma (EC) is the seventh-most prevalent tumour in the world, which is still the primary cause of tumour-related death. Identifying noteworthy biomarkers for EC is particularly significant in guiding active and effective treatment. Recently, circulating tumour cells (CTCs) in peripheral blood (PB) were intensively discussed as prognostic markers in patients with EC. However, an ongoing controversy still exists regarding the prognostic significance of CTCs determined using the CellSearch System in EC sufferers. This meta-analysis was designed to approach this topic. Methods: We systematically conducted searches using PubMed, Medline, Web of Science and the Cochrane Library for relevant studies, which were published through February 20, 2020. Using the random-effects model, our study was performed in Review Manager software, with odds ratios (ORs), risk ratios (RRs), hazard ratios (HRs) and 95% confidence intervals (CIs) as effect values. Results: In total, 7 articles were finally included in this study. For clinicopathological characteristics, the pooled results on TNM stage indicated that the III/IV group had higher incidence of CTCs compared with the I/II group (OR=1.36, 95% CI (0.68,2.71), I2=0%). Incidence of CTCs was higher among patients on T3/T4 stage (OR=2.92, 95% CI (1.31,6.51), I2=0%) and distant metastasis group (OR=5.18, 95% CI (2.38,11.25), I2=0%) compared to patients on T1/T2 stage or non-metastatic group. The pooled analysis revealed that CTC positivity detected in EC patients was correlated with poor overall survival (OS) (HR =2.83, 95% CI (1.99,4.03), I2=0%) and relapse-free survival (RFS) (HR =4.71, 95% CI (2.73,8.13), I2=0%). When pooling the estimated RR, a poor therapeutic response to chemoradiotherapy was discovered in patients with CTC positivity (RR =1.99, 95% CI (1.73,2.29), I2=60%). Conclusions: In summary, our meta-analysis demonstrated that CTCs from PB of EC patients determined using the CellSearch System are correlated with the prognosis of EC patients and might indicate a poor therapeutic response to chemotherapy in EC patients.
Time spent on provision of Antenatal Care and associated factors among public and private health facilities in Axum town, North Ethiopia: Comparative cross sectional study
Authors: Nerea Nigusse Gebremedhn , Alema Haileselasie Berhane , Tesfay Mulubirhan Tirfe 
Published: April 2020

Abstract
BackgroundIn most developing countries contact time between antenatal care attendees and providers have effects on health outcomes and quality of antenatal services. Effectiveness of focused antenatal care relies on standard time spent provisions. Hence this study evaluated the time spent & associated factors on provision of antenatal care in public and private health facilities in Axum Town, Northern Ethiopia.MethodsInstitutional based comparative cross-sectional mixed quantitative and qualitative methods were used. Data was collected through exit interviews with 456 antenatal care attendees. Qualitative data were also collected using an in-depth interview with providers. The collected data were entered using EPI info version 3.5.1 software then exported to SPSS version 21 software for analysis. Finally, multivariate logistic regression was employed to identify determinants of time spent on antenatal care provision at p-value < 0.05.ResultsMajority 378 (84.8%) of pregnant woman were served below the mean standard time in both public and private health facilities. The mean (± SD) time spent for first antenatal care provision in private was 19.7 (± 8.5) minutes, which is higher than public health facilities with mean time spent (± SD) of 13.2 (± 3.8) minutes. The mean time spent on antenatal care was significantly different in public and private health facilities. Factors that significantly affect time spent on provision of antenatal care were: type of health facilities [AOR = 2.60; 95% CI, 1.07–6.33], frequency of antenatal care visit [AOR = 3.50; 95% CI, 1.92–6.36] and language similarity with provider [AOR = 2.74; 95% CI, 1.23–6.12].ConclusionThe mean time spent for first and revisit of ANC in both health facilities was lower than the WHO standards. Type of health facilities, frequency of antenatal care visit and language similarity with provider were predictors for time spent on ANC provision. Efforts should be targeted on standard provision of antenatal care.
Parents’ health information seeking behaviour – does the child’s health status play a role?
Authors: Baumann Isabel , Jaks Rebecca , Robin Dominik , Juvalta Sibylle , Dratva Julia 
Published: April 2020

Abstract
BackgroundDigital media are increasingly abundant and being used to seek health information. To date, very little is known about parental seeking behaviour for child health information outside of English-speaking and Nordic countries. Our study “Digital parental counsellors” examines how parents search for health information in digital media, print media and among personal contacts, distinguishing between the search for information about general child health and development and child’s acute illness, and comparing information seeking behaviour by disability status of the child.MethodsA questionnaire was sent to 2573 parents (response rate: 30%) to a population-based sample of parents with children aged 0–2 years (N = 769). We developed a frequency score of use of different information sources and conducted bivariate and multivariate linear regression analyses to describe parental search behaviour and the association with child’s disability status.ResultsThe sample consists of 88% mothers (mean age: 35.7 years SD 4.33). Children’s mean age is 16 months (SD 7.1), 49% of the children are female and 6% have a disability. Parents use digital media significantly more frequently to search for information about general health and development questions than about an acute child’s illness (p < 0.001). In case of acute child’s illness, parents refer to their paediatrician, family members and other personal contacts significantly more frequently than other information sources (p < 0.001). The use of digital media and personal contacts does not significantly vary between parents with and without a disabled child, whereas the use of print media does (p < 0.02). Moreover, irrespective of disability, 45% of parents resort to the Internet prior to a paediatric visit and 27% after a visit when a visit did not answer all questions.ConclusionsDespite the high prevalence of digital media, personal contacts are still the most frequent health information resource for parents with young children. Parents combine all information resources (online, print, personal network) to improve their understanding or check the validity of information received regarding their child’s health. It is thus of utmost importance, that the increasingly accessed digital information parents search for is correct, understandable and addresses parent’s concerns.Trial registration:BASEC Req-2017-00817 (30 October 2017)
The Benefit of Advanced Age on Survival in Patients Undergoing Laparoscopic Pancreaticodoudenectomy, A Multi-Center, Comparative study-Cohort Study
Authors: Hendi Maher , Mou Yiping , Lu Chao , Zhang Bin , Xu Xiaowu , Zhang Renchao , cheng Zhouyu , Chen Ke 
Published: April 2020

Abstract
Background: Management of malignant diseases in elderly patients has become a global clinical issue because of the increased life expectancy worldwide. The advancements in surgical techniques and perioperative management have reduced age-related contraindications for LPD. Past papers have reported that elderly patients undergoing laproscopic pancreatoduodenectomy (LPD) are at an increased risk compared to non-elderly patients. The aim of this paper is to compare a single centre risk of LPD in elderly and non-elderly patients.Methods: Retrospective review (n = 237) of perisurgical outcomes in patients undergoing LPD during the months of September 2012–December 2017. Outcomes in elderly patients (aged ≥75 years) were compared with those in non-elderly patients.Results: In elderly patients, transfer to ICU was more frequent (odds ratio [OR] 6.49, P = 0.001) and mean hospital stay was lengthier (21.4 days compared with 16.6 days, （P = 0.0033) than for non-elderly patients. There was no statistically significant difference in operation time (P=0.494), estimated blood loss (P=0.0519), blood transfusion (P=0.863), decreased gastric emptying (DGE) (P=0.397), abdominal pain (P=0.454), food intake (P=0.241), time to self ambulation (P=1), reoperation (P=0.543), postoperative pancreatic fistula (POPF) grade A (P=0.454), POPF grade B (P=0.736), POPF grade C (P=0.164), hemorrhage (P=0.319), bile leakage (P=0.428), infection (P=0.259), GI bleeding (P=0.286), morbidity (P=0.272) or mortality (P=0.449) between the two groups.Conclusions: Elderly patients who underwent LPD in this study had significantly good overall survival after LPD and similar to young patients . The perioperative and long term outcomes of LPD are not worse .The Both rate of ICU admission and hospital stay increased in elderly patients undergoing LPD when compared with non-elderly ones. LPD can be performed on elderly patients with similar outcomes as younger patients; therefore Age it self should not be a contraindication to LPD for pancreatic cancer, but it suggests that elderly patients with comorbidities should be more stringently selected for surgery.
Factors influencing delivery of intersectoral actions to address infant stunting in Bogotá, Colombia – a mixed methods case study.
Authors: Botero-Tovar Natalia , Zuluaga Gina Paola Arocha , Varela Andrea Ramírez 
Published: April 2020

Abstract
Background
Intersectoral actions (ISA) are a recognized relationship between the health sector and other sectors to improve health outcomes. Although a frequent topic in public health, evidence for systematic evaluation of implementation of ISA is scarce. An intersectoral health intervention for infants under one-year-old with, and at risk of, stunting (low height-for-age) was developed by a public-private partnership in Bogotá, Colombia, during 2018 and 2019. Here we report a case study conducted in parallel to the intervention designed to assess factors that influenced implementation of the ISA.
Methods
The case study was developed using a concurrent mixed-methods design, with the qualitative component giving context to the quantitative results. The qualitative component was obtained from four workshops, three focal groups, and 17 semi-structured interviews with actors involved in the intersectoral intervention. The quantitative component was obtained with two questionnaires that evaluated perceptions on improvement and partnership functioning of the ISA.
Results
This study collected information from 122 participants. The intervention demanded intersectoral collaboration. Political will, motivated human resources, and recognition that health results from collaboration facilitated intersectoral actions. Intersectoral actions were limited by difficulties in engaging the health sector, communication challenges related to local health service decentralization, and administrative barriers.
Conclusions
Intersectoral actions have been recently discussed in the literature due to challenges on implementation, idealization, inconsistent demands, and doubts about economic outcomes. The implementation of intersectoral public health interventions can be jeopardized by a lack of coordination and management skills.
Using Behaviour Change Theories to Understand Pediatric Emergency Discharge Communication Interventions
Authors: Gallant Allyson J , Bishop Andrea , Cassidy Christine , Egar Jeanne , Curran Janet 
Published: April 2020

Abstract
Background

Interventions to improve discharge communication in emergency practice settings are inherently complex and incorporate multiple strategies aimed at patient, caregiver and healthcare provider behaviours. Behaviour change theories, including the capability-opportunity-motivation-behaviour (COM-B) model and Behaviour Change Technique Taxonomy version 1 (BCTTv1), provide consistent language for identifying and evaluating the active components of interventions. The objectives of this study were to: (1) identify common barriers and enablers to discharge communication interventions and (2) describe behaviour change techniques (BCTs) present in pediatric emergency discharge communication interventions aimed at patients, caregivers and health care providers.
Methods

We conducted a secondary analysis of 35 experimental and quasi-experimental studies included in a narrative synthesis of discharge communication interventions in pediatric emergency care. Included studies were reviewed to identify reported barriers and enablers to implementation and intervention effectiveness, which were then mapped to the COM-B model. Trained BCT coders independently coded intervention descriptions using the BCTTv1 as a coding framework. Consensus was used to resolve any discrepancies. BCTs were analyzed using descriptive statistics to determine the frequency of the 93 individual BCTs and 16 BCT categories for patient/caregiver and health care provider interventions.
Results

Barriers and enablers were identified at the patient/caregiver, health care provider, intervention and health system levels. Psychological capability was the most frequently coded COM-B component. Of the 33 studies that included BCTs, 29 interventions targeted patients or caregivers. A total of 20 different individual BCTs were identified across the interventions in the 33 studies. The number of BCTs identified in each study ranged from 1–9 BCTs, with most (n = 14, 42%) interventions containing one BCT. Reporting deficiencies were noted related to adequate details of intervention components and implementation fidelity.
Conclusions

The COM-B model and BCTTv1 proved to be useful tools to provide a foundational understanding of the common mechanisms used in pediatric discharge communication interventions. With only a fraction of the available BCTs were used in the included studies, future research is needed to explore the utility of other BCTs to address common implementation barriers and improve the effectiveness of discharge communication interventions.
The role of the General Practitioner in managing age-related hearing loss: Perspectives of General Practitioners, patients and practice staff
Authors: Bennett Rebecca Jane , Fletcher Susan , Conway Nicole , Barr Caitlin 
Published: April 2020

Abstract
Background
For people with hearing loss, the General Practitioner (GP) can play an instrumental role in early detection of hearing loss as well as guiding appropriate and timely choices for addressing hearing concerns. The aim of this study was to generate a conceptual framework for understanding the role of the GP in managing age-related hearing loss.
Methods
Concept mapping techniques were used to gather the perspectives of GPs (n = 8), adults with hearing loss (n = 22), and professionals working with GPs (n = 5), in Australia. Participants generated statements describing the role of the GP in managing age-related hearing loss, and then grouped the statements to identify key themes, via an online portal.
Results
Ninety-eight items describing the role of the GP in managing age-related hearing loss were identified across six concepts: 1) Determine - Diagnose - Discuss, 2) Ask - Assess - Act, 3) Know - Refer - Coordinate, 4) Inform - Advise - Partner, 5) Educate - Strategise - Encourage, 6) Reassure - Support - Empower.
Conclusions
The role of the GP in managing age-related hearing loss is multifaceted and requires partnership that motivates and empowers patients’ to overcome their hearing concerns. Enlisting the help of Practice Nurses, Practice Managers and local audiologists could help GPs improve their hearing loss detection and intervention rates.
Implementation of the Cardiovascular Health Awareness Program (CHAP) for adults on a waiting list for a family physician
Authors: Kaczorowski Janusz , Lussier Marie-Thérèse , Girard Magali , Beaulieu-Carbonneau Audrey 
Published: April 2020

Abstract
Background: The Cardiovascular Health Awareness Program (CHAP) was originally developed and evaluated as a community-based cardiovascular disease (CVD) prevention program in communities where access to family physicians was not a significant issue. Many Canadians now face sub-optimal access to a regular source of primary healthcare. Centralised waiting lists and prioritization based on urgency of medical need were created to address this problem. Our objective was to assess the potential benefits of offering a modified version of the CHAP program to adults on the waiting list.Methods: The implementation was conducted in Laval (Canada), targeting individuals 40 years of age or older who were registered on the waiting list (GACO) and had a priority code of 3. Participants were invited through a personalized letter to attend sessions in community health centres. The sessions were facilitated by trained volunteers and supervised by a nurse. During the sessions, participants completed CVD risk profiles, risk of type 2 diabetes questionnaire (CANRISK); had their blood pressure, height and weight as well as waist circumference measured; received targeted healthy lifestyle and patient education materials; and were referred to local programs including a medical follow-up, when required. Results: A total of 2,036 invitation letters were sent resulting in 281 (14.2%) participants attending one of 26 3-hour sessions held in 4 community health centres, assisted by 33 volunteers and supervised by a nurse. The average age of attendees was 58.1 (SD=8.2) and a majority were female (58%, n=163). Most participants were sedentary (57.3%, n=161), had low fruit and vegetable consumption (54.4%, n=153), and were overweight (38.9%, n=109) or obese (41.7%, n=117). A third of participants (34.2%, n=96) had BP ≥140/90 and 11.4% (n=32) were classified as having a very high risk for developing diabetes. Over 40% (n=117) of participants were referred to health promotion programs offered by local health authorities and 4.6% (n=13) were referred to family physicians or emergency departments (1.8%, n=5) for short-term medical assistance.Conclusions: Many Laval adults on a waiting list for a family physician would greatly benefit from having a regular source of primary healthcare to prevent, delay, and manage their cardiovascular health.
Work related factors affecting the retention of medical officers in the preventive health sector in Sri Lanka
Authors: Arnold Mahendra , Fernando Dinusha , Wickramanayake Kapila , Karunapema Palitha , Wickramatilake Sepali , Fernando Yamuna , Denawaka Chandani , Mahesh Pasyodun Koralage Buddhika , Panditharathna Sujeewa 
Published: April 2020

Abstract
Background

Human resources are the livelihood of all types of organizations. The biggest challenge that organizations are facing today is not only managing these resources but also retaining them. Preventive health sector plays a vital role in the healthcare system. Medical Officers of Health (MOH) are the Medical Officers providing preventive health services in Sri Lanka. This study was carried out to explore the factors affecting retention of Medical Officers of Health in the preventive health sector in Sri Lanka.
Methods

A descriptive cross sectional study was carried out among Medical Officers of Health in the Colombo district which has 18 MOH Offices with 64 Medical Officers. A pre-tested self-administered questionnaire was used as the study instrument. Data were analyzed using descriptive analysis, correlation and regression analysis.
Results

Regression analysis showed that all four variables; recognition, work schedule, remuneration and responsibility are positively and significantly correlated with retention of Medical Officers of Health in the preventive health sector. The variable ‘work schedule’ showed the highest impact to the retention of Medical Officers of Health.
Conclusions

In order to retain trained Medical Officers of Health in the Sri Lankan preventive health sector, health authorities should address the factors that influence retention. If policy makers fail to address these factors the preventive health services will be negative impact due to shortage of key service providers.
A single-center experience with service organization for patients with ARFID
Authors: Norris Mark , Obeid Nicole , Santos Alexandre , Valois Darcie , Isserlin Leanna , Feder Stephen , Spettigue Wendy 
Published: April 2020

Abstract
Background

To date, very little research has explored the impact that the newly articulated diagnosis Avoidant restrictive food intake disorder (ARFID) has had on feeding and eating disorder program service organization and delivery. The purpose of this paper is to provide a descriptive overview of a single-center, ARFID-specific pilot clinic that sought to better understand the specific needs of patients with ARFID and gain insight into treatment requirements.
Methods

A retrospective cohort study was completed on patients with ARFID admitted to a specialized pilot clinic within a tertiary care hospital.
Results

Over an 18 month period, a total of 31 patients were assessed, with 26 patients completing follow-up assessments. Patients presented with heterogeneous manifestations of ARFID, with treatment plans tailored to meet individual needs at assessment and over the treatment period. A multidisciplinary approach was most often administered, including a combination of administered individual therapy, family therapy, medical monitoring, and prescribed medications. Only 30% of patients were treated exclusively by therapists on the eating disorder team.
Conclusions

The experiences gained from this pilot study highlight the need for specialized resources for assessment and treatment of patients with ARFID, the importance of a multidisciplinary approach to treatment, and the necessity of utilization of ARFID-specific measures for program evaluation purposes.