bluuebunny/crossref_metadata_2025_split huggingface dataset:
DAS SUBJEKT DER LYRIK ODER: FÜR EINE PHILOLOGIE DER DUNKELHEIT – LYRIK ALS (EIN) PARADIGMA DER MODERNE
Authors: Emmrich Thomas 
Published: October 2020

AbstractWhen Hölderlin argues in favour of modernity in the Querelle des Anciens et des Modernes, he rejects the claim that the highest form of art is tragedy and proclaims the primacy of poetry. However, Hölderlin frames a very different concept of poetry from Hegel, for instance, one of the most prominent representatives of the notion of subjectivity. For Hölderlin, poetry is not the medium of subjective self‐reassurance, but first and foremost the genre of memory, of patient endurance ‘when times are hard’ and of writing against ‘eccentric excitement’. It is through writing that he expects to achieve a revolution in future ‘modes of thought’. Hölderlin wants not only to define a poetics of genre for modernity but also to imbue it with an autonomous aesthetic profile, independent of the worn‐out language of tradition. This is why the language of modern poetry can only be one of obscuritas. This struggle for a genuinely modern mode of speaking leads to changes in the old modes, to alienation from them and, as a result, to the estrangement of recipients. Firstly, this article will reconstruct how the paradigmatic genre of modernity shifts from tragedy to poetry. Secondly, it will analyse Hölderlin's nexus between critiques of the subject and critiques of poetic language and then trace the paths that lead from it to Adorno.
The rise of Chinese foreign direct investment in the United States: Disentangling investment strategies of state‐owned and private enterprises
Authors: He Lisha , Jiang Ronghao , Bennett Mia M. 
Published: October 2020

AbstractOver the last two decades, China's outward foreign direct investment (OFDI) has expanded rapidly. The country is now the world's second‐largest source of OFDI. China is often viewed as a monolithic investor, however, without sufficient attention to the differences between investments by state‐owned enterprises (SOEs) and private enterprises (PEs). To shed light on the internal complexity and heterogeneity of Chinese OFDI, we construct a panel dataset of investments in the U.S. across the 50 states and Washington, D.C. from 2005 to 2017, which we analyze using a spatial autoregressive model. We find clear evidence that the ownership structure of Chinese firms affects investment strategy and entry mode. Statistical analysis indicates that SOEs are more likely to pursue greenfield investment motivated by market‐seeking and resource‐seeking objectives, while PEs pursue mergers and acquisitions in order to obtain strategic assets. We also detect a positive and significant relationship between the presence of Chinese overseas communities and OFDI, with the strength of the correlation depending on ownership structure. Finally, we find that Chinese OFDI is spatially dependent, meaning that investments flow to states where they are already concentrated nearby.
Self‐care training using the Tablo hemodialysis system
Authors: Plumb Troy J. , Alvarez Luis , Ross Dennis L. , Lee Joseph J. , Mulhern Jeffrey G. , Bell Jeffrey L. , Abra Graham E. , Prichard Sarah S. , Chertow Glenn M. , Aragon Michael A. 
Published: October 2020

ABSTRACTIntroductionRecently published results of the investigational device exemption (IDE) trial using the Tablo hemodialysis system confirmed its safety and efficacy for home dialysis. This manuscript reports additional data from the Tablo IDE study on the training time required to be competent in self‐care, the degree of dependence on health care workers and caregivers after training was complete, and participants' assessment of the ease‐of‐use of Tablo.MethodsWe collected data on the time required to set up concentrates and the Tablo cartridge prior to treatment initiation. We asked participants to rate system setup, treatment, and takedown on a Likert scale from 1 (very difficult) to 5 (very simple) and if they had required any assistance with any aspect of treatment over the prior 7 days. In a subgroup of 15 participants, we recorded the number of training sessions required to be deemed competent to do self‐care dialysis.FindingsEighteen men and 10 women with a mean age of 52.6 years completed the study. Thirteen had previous self‐care experience using a different dialysis system. Mean set up times for the concentrates and cartridge were 1.1 and 10.0 minutes, respectively. Participants with or without previous self‐care experience had similar set‐up times. The mean ease‐of‐use score was 4.5 or higher on a scale from 1 to 5 during the in‐home phase. Sixty‐five percent required no assistance at home and on average required fewer than four training sessions to be competent in managing their treatments. Results were similar for participants with or without previous self‐care experience.ConclusionsParticipants in the Tablo IDE trial were able to quickly learn and manage hemodialysis treatments in the home, found Tablo easy to use, and were generally independent in performing hemodialysis.
Seeking or contributing? Evidence of knowledge sharing behaviours in promoting patients’ perceived value of online health communities
Authors: Guo Cui , Zhang Zhen , Zhou Junjie , Deng Zhaohua 
Published: October 2020

AbstractBackgroundHealth knowledge, as an important resource of online health communities (OHCs), attracts users to engage in OHCs and improve the traffics within OHCs, thereby promoting the development of OHCs. Seeking and contributing health knowledge are basic activities in OHCs and are helpful for users to solve their health‐related problems, improve their health conditions and thus influence their evaluation of OHCs (ie perceived value of OHCs). However, how do patients’ health knowledge seeking and health knowledge contributing behaviours together with other factors influence their perceived value of OHCs? We still have little knowledge.ObjectiveIn order to address the above gap, we root the current study in social cognitive theory and prior related literature on health knowledge sharing in OHCs and patients’ perceived value. We treat health knowledge seeking and health knowledge contributing behaviours as behavioural factors and structural social capital as an environmental factor and explore their impacts on patients’ perceived value of OHCs.DesignWe have built a theoretical model composed of five hypotheses. We have designed a questionnaire composed of four key constructs and then collected data via an online survey.Setting and participantsWe have distributed the questionnaire in two Chinese OHCs. We obtained a sample of 352 valid responses that were completed by patients having a variety of conditions.ResultsThe empirical results indicate that health knowledge seeking and health knowledge contributing have positive impacts on patients’ perceived value of OHCs. The impact of health knowledge seeking on patients’ perceived value of OHCs is greater than the impact of health knowledge contributing. In addition, structural social capital moderates the effects of health knowledge seeking and health knowledge contributing on patients’ perceived value of OHCs. It weakens the effect of health knowledge seeking but enhances the effect of health knowledge contributing on patients’ perceived value of OHCs.ConclusionsThese findings contribute to the literature on patients’ perceived value of OHCs and on the role of structural social capital in OHCs. For OHC managers, they should provide their users more opportunities to seek or contribute health knowledge in their communities.
Antiretroviral treatment outcomes among late HIV presenters initiating treatment with integrase inhibitors or protease inhibitors
Authors: Schuettfort G , Boekenkamp L , Cabello A , Cotter AG , De Leuw P , Doctor J , Górgolas M , Hamzah L , Herrmann E , Kann G , Khaykin P , Mallon PW , Mena A , Del Palacio Tamarit M , Sabin CA , Stephan C , Wolf T , Haberl AE 
Published: October 2020

ObjectivesThe aim of the study was to investigate the efficacy and safety of first‐line antiretroviral therapy (ART) with integrase inhibitor (INI) or protease inhibitor (PI)‐based regimens in patients with low CD4 cell counts and/or an AIDS‐defining disease.MethodsWe conducted a retrospective, multicentre analysis to investigate discontinuation proportions and virological response in patients with CD4 cell counts < 200 cells/µL and/or AIDS‐defining disease when starting first‐line ART. Proportions of those discontinuing ART were compared using univariate analysis. Virological response was analysed using the Food & Drug Administration (FDA) snapshot analysis (HIV‐1 RNA < 50 HIV‐1 RNA copies/mL at week 48).ResultsTwo hundred and eighteen late presenters were included in the study: 13.8% were women and 23.8% were of non‐European ethnicity, and the mean baseline CD4 count was 91 cells/µL (standard deviation 112 cells/µL). A total of 131 late presenters started on INI‐ and 87 on PI‐based treatment. It was found that 86.1% of patients treated with INIs and 81.1% of patients treated with PIs had a viral load < 50 copies/mL at week 48; proportions of discontinuation because of adverse events were 6.1% in the INI group and 11.5% in the PI group. No significant differences in discontinuation proportions were observed at week 12 or 48 between INI‐ and PI‐based regimens (P = 0.76 and 0.52, respectively). Virological response was equally good in those receiving INIs and those receiving PIs (86.1% vs. 81.1%, respectively; P = 0.36).ConclusionsIn a European cohort of late presenters starting first‐line INI or PI‐based ART regimens, there were no significant differences in discontinuation proportions or virological response at week 48.
TESTING PASSIVE VERSUS SYMMETRIC BELIEFS IN CONTRACTING WITH EXTERNALITIES
Authors: Zhang Daiqiang 
Published: October 2020

AbstractThis article provides identification and estimation methods for a model of contracting with externalities and imperfect information. In this model, one principal offers a contract of trade quantity to each of multiple agents, and the negotiated payment for each agent is determined via Nash bargaining. Beliefs matter due to the privacy of bilateral contracting and the externalities from the dependence of each agent's payoff on all agents' trade quantities. We provide a test to determine whether passive or symmetric beliefs fit a given data set better. The empirical results suggest the relevance of adopting the correct beliefs for policy evaluations.
Genomic characteristics revealed by targeted exon sequencing of testicular germ cell tumors in Japanese men
Authors: Matsumoto Takashi , Shiota Masaki , Uchiumi Takeshi , Ueda Shohei , Tsukahara Shigehiro , Toshima Takahiro , Matsumoto Shinya , Noda Nozomi , Eto Masatoshi , Kang Dongchon 
Published: October 2020

ObjectiveTo investigate the somatic mutation profiles of testicular germ cell tumors in Japanese men.MethodsWe analyzed the somatic missense mutation profile of testicular germ cell tumors among 21 Japanese men with seminoma (n = 14), pure embryonic carcinoma (n = 3) and mixed testicular germ cell tumor (n = 4) by targeted next‐generation sequencing of 409 cancer‐related genes covering 1.23 Mb of the genome.ResultsWe identified a total of 22 missense mutations in 21 primary testicular germ cell tumor samples (0.89 mutations/Mb), of which seven mutations were confirmed to be absent from the germline. KIT:p.Asn822Tyr, KIT:p.Leu576Pro, PIK3CA:p.Glu542Lys and FBXW7:p.Arg505His were statistically and functionally potential. A total of 18 missense mutations were previously unknown in testicular germ cell tumors. PDGFRA amplification from one patient with seminoma was detected. KIT, BCR,PIK3CG, PIK3CA and PDGFRA mutations involved in aberrant signaling of the KIT–PI3K–AKT pathway was detected in 27.3% of detected mutations.ConclusionsThe present investigation identified a low mutation rate in testicular germ cell tumors among Asian patients, 18 novel mutations and PDGFRA amplification. Limitations of the present study are the small sample and missing normal DNA for some testicular germ cell tumors.
Tumor resistance mechanisms and their consequences on γδ T cell activation
Authors: Wesch Daniela , Kabelitz Dieter , Oberg Hans‐Heinrich 
Published: October 2020

AbstractHuman γδ T lymphocytes are predominated by two major subsets, defined by the variable domain of the δ chain. Both, Vδ1 and Vδ2 T cells infiltrate in tumors and have been implicated in cancer immunosurveillance. Since the localization and distribution of tumor‐infiltrating γδ T cell subsets and their impact on survival of cancer patients are not completely defined, this review summarizes the current knowledge about this issue. Different intrinsic tumor resistance mechanisms and immunosuppressive molecules of immune cells in the tumor microenvironment have been reported to negatively influence functional properties of γδ T cell subsets. Here, we focus on selected tumor resistance mechanisms including overexpression of cyclooxygenase (COX)‐2 and indolamine‐2,3‐dioxygenase (IDO)‐1/2, regulation by tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL)/TRAIL‐R4 pathway and the release of galectins. These inhibitory mechanisms play important roles in the cross‐talk of γδ T cell subsets and tumor cells, thereby influencing cytotoxicity or proliferation of γδ T cells and limiting a successful γδ T cell‐based immunotherapy. Possible future directions of a combined therapy of adoptively transferred γδ T cells together with γδ‐targeting bispecific T cell engagers and COX‐2 or IDO‐1/2 inhibitors or targeting sialoglycan‐Siglec pathways will be discussed and considered as attractive therapeutic options to overcome the immunosuppressive tumor microenvironment.
Costs of a clinical pathway with point‐of‐care testing during influenza epidemic in a Dutch hospital
Authors: Marbus Sierk D. , Lutgens Suzanne P. M. , van Gageldonk‐Lafeber Arianne B. , Hazenberg Eric H. L. C. M. , Hermans Mirjam H. A. , Suijkerbuijk Anita W. M. 
Published: October 2020

AbstractOur study aim was to determine how a new clinical pathway, including PCR‐based influenza point‐of‐care test (POCT), influences the hospitalisation costs of patients suspected of influenza presenting at the emergency department of a Dutch hospital during two consecutive influenza epidemics (2016‐2017 and 2017‐2018). Compared to mean costs per patient of €3661 in 2016‐2017, the implementation of this new clinical pathway with influenza POCT in 2017 was associated with mean costs per influenza‐positive patient of €2495 in 2017‐2018 (P = .3). Our study suggests favourable economic results regarding a new clinical pathway with influenza POCT, reflecting a more efficient care of patients suspected of influenza presenting at the emergency department.
Factors contributing to reported medication administration incidents in patients’ homes – A text mining analysis
Authors: Härkänen Marja , Franklin Bryony Dean , Murrells Trevor , Rafferty Anne Marie , Vehviläinen‐Julkunen Katri 
Published: October 2020

AbstractAimsTo describe the characteristics of medication administration (MA) incidents reported to have occurred in patients’ own homes (reporters’ profession, incident types, contributing factors, patient consequence, and most common medications involved) and to identify the connection terms related to the most common contributing factors based on free text descriptions.DesignA retrospective study using descriptive statistical analysis and text mining.MethodsMedication administration incidents (N = 19,725) reported to have occurred in patients’ homes between 2013–2018 in one district in Finland were analysed, describing the data by the reporters’ occupation, incident type, contributing factors, and patient consequence. SAS® Text Miner was used to analyse free text descriptions of the MA incidents to understand contributing factors, using concept linking.ResultsMost MA incidents were reported by practical (lower level) nurses (77.8%, N = 15,349). The most common category of harm was ‘mild harm’ (40.1%, N = 7,915) and the most common error type was omissions of drug doses (47.4%, N = 9,343). The medications most commonly described were Marevan [warfarin] (N = 2,668), insulin (N = 811), Furesis [furosemide] (N = 590), antibiotic (N = 446), and Panadol [paracetamol] (N = 416). The contributing factors most commonly reported were ‘communication and flow of information’ (25.5%, N = 5,038), ‘patient and relatives’ (22.6%, N = 4,451), ‘practices’ (9.9%, N = 1,959), ‘education and training’ (4.8%, N = 949), and ‘work environment and resources’ (3.0%, N = 598).ConclusionThere is need for effective communication and clear responsibilities between home care patients and their relatives and health providers, about MA and its challenges in home environments. Knowledge and skills relating to safe MA are also essential.ImpactThese findings about MA incidents that have occurred in patients’ homes and have been reported by home care professionals demonstrate the need for medication safety improvement in home care.
Down‐regulated HDAC3 elevates microRNA‐495‐3p to restrain epithelial‐mesenchymal transition and oncogenicity of melanoma cells via reducing TRAF5
Authors: Ma Yanbo , Duan Jincheng , Hao Xiuyan 
Published: October 2020

AbstractMicroRNAs (miRNAs) are emerging biomarkers in biological processes and the role of miR‐495‐3p has been identified in melanoma, while the detailed molecular mechanisms remain to be further explored. We aim to explore the effect of histone deacetylase 3 (HDAC3) and miR‐495‐3p on epithelial‐mesenchymal transition (EMT) and oncogenicity of melanoma cells by regulating tumour necrosis factor receptor‐associated factor 5 (TRAF5). Levels of HDAC3, miR‐495‐3p and TRAF5 in melanoma tissues and pigmented nevus tissues were determined, and the predictive roles of HDAC3 and miR‐495‐3p in prognosis of melanoma patients were measured. The melanoma cells were screened and transfected with relative oligonucleotides and plasmids, and the expression of HDAC3, miR‐495‐3p and TRAF5, and phenotypes of melanoma cells were gauged by a series of assays. The relations between HDAC3 and miR‐495‐3p, and between miR‐495‐3p and TRAF5 were confirmed. HDAC3 and TRAF5 were increased while miR‐495‐3p was decreased in melanoma cells and tissues, and the low expression of miR‐495‐3p as well as high expression of HDAC3 indicated a poor prognosis of melanoma patients. Inhibited HDAC3 elevated miR‐495‐3p to suppress EMT and oncogenicity of melanoma cells by reducing TRAF5. HDAC3 particularly bound to miR‐495‐3p and TRAF5 was the target gene of miR‐495‐3p. Our results revealed that down‐regulated HDAC3 elevates miR‐495‐3p to suppress malignant phenotypes of melanoma cells by inhibiting TRAF5, thereby repressing EMT progression of melanoma cells. This study may provide novel targets for melanoma treatment.
Exosomes mediate an epithelial‐mesenchymal transition cascade in retinal pigment epithelial cells: Implications for proliferative vitreoretinopathy
Authors: Zhang Yao , Wang Kaizhe , Pan Jiabin , Yang Shuai , Yao Haipei , Li Min , Li Hui , Lei Hetian , Jin Haiying , Wang Fang 
Published: October 2020

AbstractExosomes have recently emerged as a pivotal mediator of many physiological and pathological processes. However, the role of exosomes in proliferative vitreoretinopathy (PVR) has not been reported. In this study, we aimed to investigate the role of exosomes in PVR. Transforming growth factor beta 2 (TGFß‐2) was used to induce epithelial‐mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells, as an in vitro model of PVR. Exosomes from normal and EMTed RPE cells were extracted and identified. We incubated extracted exosomes with recipient RPE cells, and co‐cultured EMTed RPE cells and recipient RPE cells in the presence of the exosome inhibitor GW4869. Both experiments suggested that there are further EMT‐promoting effects of exosomes from EMTed RPE cells. MicroRNA sequencing was also performed to identify the miRNA profiles in exosomes from both groups. We identified 34 differentially expressed exosomal miRNAs (P <. 05). Importantly, miR‐543 was found in exosomes from EMTed RPE cells, and miR‐543‐enriched exosomes significantly induced the EMT of recipient RPE cells. Our study demonstrates that exosomal miRNA is differentially expressed in RPE cells during EMT and that these exosomal miRNAs may play pivotal roles in EMT induction. Our results highlight the importance of exosomes as cellular communicators within the microenvironment of PVR.
Peculiar blood flow profiles among placental chorionic villous vessels of an abnormally thick placenta in a case of systemic lupus erythematosus characterized using microvascular imaging
Authors: Inoue Asami , Horinouchi Takashi , Yoshizato Toshiyuki , Kojiro‐Sanada Sakiko , Kozuma Yutaka , Ushijima Kimio 
Published: October 2020

AbstractWe present a patient with systemic lupus erythematosus receiving long‐term steroid therapy, who had myometrial thinning, markedly thickened placenta, and fetal growth restriction (FGR). Blood flow profiles of the myometrium, decidua and placental villous vessels (VV) were described using superb microvascular imaging (SMI) at 35 weeks' gestation. Images showed no decidual blood flow underneath the placenta sitting on a thin myometrium and sparse VV distribution and non‐visualization of peripheral VV flow. Emergency cesarean hysterectomy was performed at 36 weeks. Histological findings showed missing decidua on the thin myometrium, which indicated placenta accreta spectrum, and massive perivillous fibrin deposition and increased numbers of syncytial knots in the placenta. We speculated that the thick placenta and peculiar VV flow profiles resulted from congestion of the intervillous space and intervillous underperfusion/low intraplacental oxygenation, respectively, resulting in FGR. Superb microvascular imaging is useful for diagnosing placenta accreta spectrum and understanding the pathophysiology of thick placenta and FGR.
Pain complications of oral implants: Is that an issue?
Authors: Conti Paulo César Rodrigues , Bonjardim Leonardo Rigoldi , Stuginski‐Barbosa Juliana , Costa Yuri Martins , Svensson Peter 
Published: October 2020

AbstractThe use of oral implants as a form of replacing missing teeth in partial or total edentulous patients is considered the gold standard in oral rehabilitation. Although considered a history of success in contemporary dentistry, surgical complications may occur, as excessive bleeding, damage to the adjacent teeth and mandibular fractures. Persistent pain and abnormal somatosensory responses after the surgery ordinary healing time are also potential problems and may lead to the development of a condition named posttraumatic trigeminal neuropathic pain (PTNP). Though relatively rare, PTNP has a profound impact on patient’s quality of life. Appropriated previous image techniques, effective anaesthetic procedures and caution during the surgical procedure and implant installation are recommended for the prevention of this condition. In case of the PTNP, different management modalities, including antidepressant and membrane stabilizer medications, as well as peripheral strategies, as the use of topical medication and the botulin toxin are presented and discussed.