bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Italian arm of the PREPARE study: an international project to evaluate and license a maternal vaccine against group B streptococcus
Authors:   the Prepare Network, Berardi Alberto , Cassetti Tiziana , Creti Roberta , Vocale Caterina , Ambretti Simone , Sarti Mario , Facchinetti Fabio , Cose Stephen , Heath Paul , Le Doare Kirsty 
Published: October 2020

Abstract

Background
Group B streptococcus (GBS) is a leading cause of sepsis, pneumonia and meningitis in infants, with long term neurodevelopmental sequelae. GBS may be associated with poor pregnancy outcomes, including spontaneous abortion, stillbirth and preterm birth. Intrapartum antibiotic prophylaxis (IAP) is currently the only way to prevent early-onset disease (presenting at 0 to 6 days of life), although it has no impact on the disease presenting over 6 days of life and its implementation is challenging in resource poor countries. A maternal vaccine against GBS could reduce all GBS manifestations as well as improve pregnancy outcomes, even in low-income countries.

Main body
The term “PREPARE” designates an international project aimed at developing a maternal vaccination platform to test vaccines against neonatal GBS infections by maternal immunization. It is a non-profit, multi-center, interventional and experimental study (promoted by the St George University of London. [UK]) with the aim of developing a maternal vaccination platform, determining pregnancy outcomes, and defining the extent of GBS infections in children and mothers in Africa. PREPARE also aims to estimate the protective serocorrelates against the main GBS serotypes that cause diseases in Europe and Africa and to conduct two trials on candidate GBS vaccines.
PREPARE consists of 6 work packages. In four European countries (Italy, UK, Netherlands, France) the recruitment of cases and controls will start in 2020 and will end in 2022. The Italian PREPARE network includes 41 centers. The Italian network aims to collect: GBS isolates from infants with invasive disease, maternal and neonatal sera (cases); cord sera and GBS strains from colonized mothers whose infants do not develop GBS infection (controls).

Short conclusion
PREPARE will contribute information on protective serocorrelates against the main GBS serotypes that cause diseases in Europe and Africa. The vaccine that will be tested by the PREPARE study could be an effective strategy to prevent GBS disease.
The association of mental disorders with perceived social support, and the role of marital status: results from a national cross-sectional survey
Authors: Vaingankar Janhavi Ajit , Abdin Edimansyah , Chong Siow Ann , Shafie Saleha , Sambasivam Rajeswari , Zhang Yun Jue , Chang Sherilyn , Chua Boon Yiang , Shahwan Shazana , Jeyagurunathan Anitha , Kwok Kian Woon , Subramaniam Mythily 
Published: October 2020

AbstractBackgroundThis study investigated whether (i) mental disorders were associated with perceived social support and its subcomponents, (ii) current marital status was related to perceived social support, and (iii) ‘Married’ status influenced the relationship between mental state and perceived social support.MethodsData from a cross-sectional national survey comprising 6126 respondents were used. Lifetime diagnosis for five mental disorders was assessed with a structured questionnaire. Perceived social support was measured with the Multidimensional Scale of Perceived Social Support (MSPSS) that provides Global and subscale scores for Significant Other, Family and Friends. Multiple linear regression analyses were conducted to address the research questions with MSPSS score as the dependent variable. Structural equation modeling (SEM) was performed to test mediation by marital status.ResultsAll mental disorders included in the study, except alcohol use disorder (AUD), were significantly and negatively associated with Global MSPSS scores. After controlling for sociodemographic factors and chronic physical illness, major depressive disorder (β = - 0.299, 95% CI: -0.484 – -0.113,p = 002) and having any of the five mental disorders (β = - 0.133, 95% CI: -0.254 – -0.012,p = 032) were negatively associated with support from Significant Other, while support from Family and Friends was lower among all disorders, except AUD. Being married was positively associated with perceived social support in people with and without mental disorders. Results of the SEM partially support mediation by mental state - perceived social support relationship by ‘Married’ status.ConclusionHaving mental disorders was associated with lower perceived social support. Being married has potential to influence this relationship.
Affine-transformation invariant clustering models
Authors: Huang Hsin-Hsiung , Yang Jie 
Published: October 2020

AbstractWe develop a cluster process which is invariant with respect to unknown affine transformations of the feature space without knowing the number of clusters in advance. Specifically, our proposed method can identify clusters invariant under (I) orthogonal transformations, (II) scaling-coordinate orthogonal transformations, and (III) arbitrary nonsingular linear transformations corresponding to models I, II, and III, respectively and represent clusters with the proposed heatmap of the similarity matrix. The proposed Metropolis-Hasting algorithm leads to an irreducible and aperiodic Markov chain, which is also efficient at identifying clusters reasonably well for various applications. Both the synthetic and real data examples show that the proposed method could be widely applied in many fields, especially for finding the number of clusters and identifying clusters of samples of interest in aerial photography and genomic data.
Oocyte cryopreservation in the setting of a vascular endothelial growth factor (VEGF)-producing paraneoplastic syndrome: a case report and review of literature
Authors: Spurlin Emily , Brady Paula 
Published: October 2020

AbstractBackgroundMany reproductive aged women with new oncologic diagnoses choose to undergo emergency oocyte or embryo cryopreservation prior to initiating potentially gonadal toxic oncologic therapies. Ovarian hyperstimulation syndrome (OHSS) is a potential complication of these treatments and can be particularly dangerous in these patients due to their underlying medical illness and by delaying lifesaving oncology treatment. This case report details a multipronged approach to OHSS prevention in a patient with a paraneoplastic syndrome defined by overproduction of vascular endothelial growth factor (VEGF), which is also primarily responsible for OHSS.Case presentationA 29 year old nulligravid woman was diagnosed with a rare multisystem paraneoplastic syndrome (Polyradiculoneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder and skin changes, known as POEMS) and presented for fertility preservation consultation prior to autologous stem cell transplant. She successfully underwent oocyte cryopreservation without complications due to aggressive OHSS prophylaxis with both a dopamine agonist and aromatase inhibitor during and after stimulation and a gonadotropin releasing hormone agonist (GnRH-A) for final oocyte maturation, without delay in her subsequent oncology treatment.ConclusionsThis is the first report of a patient with POEMS undergoing controlled ovarian hyperstimulation (COH). Oocyte cryopreservation was successful and without complications due to a combination of prophylactic measures against OHSS (cabergoline, letrozole and GnRH-A trigger) and close collaboration between reproductive endocrinology and oncology. This case demonstrates the use of combined measures in targeting VEGF overproduction and OHSS risk during COH.
Time-dependent electricity pricing using variable announcement horizons
Authors: Kienscherf Philipp Artur , Collins John , Joe-Wong Carlee , Ketter Wolfgang , Sen Soumya 
Published: October 2020

AbstractIn the battle against climate change, electrification plays an increasingly large role in our society. The growing use of electricity networks requires advanced coordination mechanisms to avoid the tragedy of the commons. In this paper, we explore the effects of optimum time-dependent pricing (TDP) on supplier surplus within electricity markets, using a parameterized optimization model. Varying not only the prices themselves, but also their announcement horizon, we show how the suppliers’ optimal decision depends on risk aversion, forecasting quality, and end-user flexibility. The inclusion of procurement risk in our model shows that TDP can be beneficial for suppliers when they want to actively manage risk, even if expected profits are lower. At the same time, the shifting of end-user demand to low-cost times reduces the overall system cost, and potentially carbon emissions.
A socio-psychological modal choice approach to modelling mobility and energy demand for electric vehicles
Authors: Nguyen Khoa , Schumann René 
Published: October 2020

Abstract
The development of efficient electric vehicle (EV) charging infrastructure requires modelling of consumer demand at an appropriate level of detail. Since only limited information about real customers is available, most simulations employ a stochastic approach by combining known or estimated business features (e.g. arrival and departure time, requested amount of energy) with random variations. However, these models in many cases do not include factors that deal with the social characteristics of EV users, while others do not emphasise on the economic elements. In this work, we introduced a more detailed demand model employing a modal choice simulation framework based on Triandis’ Theory of Interpersonal Behaviour, which can be calibrated by empirical data and is capable of combining a diverse number of determinants in human decision-making. By applying this model on Switzerland mobility domain, an analysis on three of the most popular EV incentives from both supply and demand sides is provided, which aims for a better understanding of electro-mobility systems by relating its causes and effects.
Death education for children and young people in public schools
Authors: Friesen Hannah , Harrison Jennifer , Peters Melissa , Epp Donna , McPherson Nancy 
Published: October 2020

BackgroundConversations about death are often associated with fear, anxiety, avoidance and misunderstandings. Many adults feel that these discussions are inappropriate and confusing for young people. In this project, two fourth-year nursing students partnered with a local palliative care team to examine death education for children. The nursing students focused on children's understandings of death and their coping abilities, the lack of appropriate discussions about death with children, and the implementation of death education in public schools. Three online death education resources were identified and evaluated for use in public schools. This project fueled preliminary local discussions and advocacy efforts in the provision of death education for children. In the future, death education will need to be incorporated into education plans at local schools, and could be done in collaboration with the local palliative care team.
Three-dimensional deeply generated holography [Invited]
Authors: Horisaki Ryoichi , Nishizaki Yohei , Kitaguchi Katsuhisa , Saito Mamoru , Tanida Jun 
Published: October 2020

In this paper, we present a noniterative method for 3D computer-generated holography based on deep learning. A convolutional neural network is adapted for directly generating a hologram to reproduce a 3D intensity pattern in a given class. We experimentally demonstrated the proposed method with optical reproductions of multiple layers based on phase-only Fourier holography. Our method is noniterative, but it achieves a reproduction quality comparable with that of iterative methods for a given class.
Wavelength selection approach for an incoherent optical detection sensor (LiDAR)
Authors: Mudge Jason 
Published: October 2020

An energy or direct detection or time-of-flight sensor (a type of incoherent optical detection sensor) used for remote detection and ranging purposes is a useful measurement tool due to its simplicity and high performance in uncluttered environments. A sensor- or top-level design approach has been established [Appl. Opt. 59, 1939 (2020)APOPAI0003-693510.1364/AO.384135] due to the usefulness of these sensors, and with this, lower-level designs can be performed to optimize the sensor for particular applications. A critical design element of an incoherent optical detection sensor, or any active optical sensor for that matter, is the selection of a best or optimal central operational wavelength. First and foremost, a relevant metric is developed to provide an optimum wavelength. Then, a search for this wavelength is generated given a generic set of components where conditions are best suited for direct detection sensors, i.e., uncluttered environments or space-like, and finally, the search is again carried out for conditions within the Earth’s atmosphere where transmission plays a role.
El mito de Casandra en Sergio Blanco
Authors: Gini Eleni 
Published: October 2020

La presente ponencia trata el monólogo teatral Kassandra del dramaturgo y director franco-uruguayo Sergio Blanco, a fin de poner de relieve cómo, a través del mito de la Guerra de Troya y especialmente, a través del personaje de la adivina Kassandra, se creó un palimpsesto en el que se reflejan los males de la guerra, del desarraigo y del exilio. Asimismo, en dicha obra se ponen de manifiesto los temas de la libertad sexual, de la dificultad que supone vivir en un mundo en el que ser diferente se considera una maldición. En la obra de Blanco, el personaje de Kassandra aparece como una chica de compañía que va –deliberadamente– hacia la muerte, se dirige a los espectadores de todo el mundo hablando en un inglés macarrónico y narra su historia con una sinceridad aplastante, que aunque antiquísima, sigue siendo relevante hoy en día. Al desplegarse la trama, la Kassandra de Blanco evoca a sus queridos Abba y Bugs Bunny, cuya máscara lleva cuando lee las letras de su monólogo euripidiano, acrecentando así la sensación de humor amargo y desasosiego.
Kassandra se ha representado al menos 14 veces en escenarios latinoamericanos y europeos y ha sido galardonada con premios de dirección y de interpretación. Su mirada subversiva le permite compartir afinidades con los monólogos inspirados en mitos antiguos del siglo XXI, tal como fueron concebidos y representados por diversos dramaturgos de renombre internacional.
Afirmación de subjetividades de los profesores de inglés en Colombia a partir de sus discursos de resistencia
Authors: Garzón Duarte Eliana 
Published: October 2020

Este artículo tiene como objetivo presentar los resultados de una investigación llevada a cabo por un grupo de profesores de la Universidad Distrital Francisco José de Caldas, en Bogotá, Colombia. La investigación se centró en problematizar el significado de subjetividad construido por los profesores de inglés en el territorio colombiano, como respuesta al Plan Nacional de Bilingüismo —proyecto diseñado e implementado por el Ministerio de Educación Nacional desde el año 2004, en Colombia. El doble carácter de la sujeción/subjetivación, planteado por Foucault (1982), es utilizado en esta investigación para analizar el trabajo de los profesores de inglés en cuanto a las prácticas del sí y las de resistencia o contestatarias, no solo para afirmarse ellos mismos como investigadores y pensadores críticos, sino también para reclamar reconocimiento como educadores que producen un saber relevante y situado. El Análisis Histórico de Discurso, a través de procedimientos arqueológicos (Foucault, 1972), se utilizó para rastrear las prácticas discursivas y no-discursivas de los profesores de inglés. Esta metodología fue clave para develar la manera como los profesores de inglés se identifican a sí mismos, su oposición a las políticas públicas de lenguaje y cómo responden ellos a los discursos dominantes en relación a la enseñanza del inglés. Más de 100 publicaciones académicas de profesores de inglés fueron revisadas y confrontadas con discursos normalizados que circulan en los programas de gobierno, medios de prensa y documentos de expertos. Los resultados de esta investigación contribuyen al entendimiento de los profesores de inglés en relación con sus propias luchas y el papel de sus prácticas de resistencia para afirmar sus subjetividades.
Call for papers, JOVACET 4(1), 2021
Authors: Robertson Catherine 
Published: October 2020

You are invited to submit an abstract for the fifth issue of JOVACET to be published in October 2021.
Deadline for abstract submissions: Friday, 26 February 2021.
Abstracts should comprise a maximum of 700 words and be submitted in MS Word format via the journal website at www.jovacet.ac.za or emailed to Dr Catherine Robertson at cathy@tcrobertson.co.za. Should you prefer to submit a full article, please limit the number of words to 8 000, which includes the abstract and list of references. The website will provide the style guide.
Contributors may share any recent research relevant to the theme and the TVET/adult learning sector. Therefore, submissions of papers are invited that respond to this call to share recent research, its conceptual framing and its findings, with a view to identifying areas of further research for exploration. Submissions should be of high quality and follow academic research/writing conventions in the social sciences. Specifications can be found on the JOVACET website or obtained from Dr Catherine Robertson at the email address above.
We look forward to receiving your submissions!
SARS‐CoV‐2 evades immune detection in alveolar macrophages
Authors: Dalskov Louise , Møhlenberg Michelle , Thyrsted Jacob , Blay‐Cadanet Julia , Poulsen Ebbe Toftgaard , Folkersen Birgitte Holst , Skaarup Søren Helbo , Olagnier David , Reinert Line , Enghild Jan Johannes , Hoffmann Hans Jürgen , Holm Christian Kanstrup , Hartmann Rune 
Published: October 2020

AbstractRespiratory infections, like the current COVID‐19 pandemic, target epithelial cells in the respiratory tract. Alveolar macrophages (AMs) are tissue‐resident macrophages located within the lung. They play a key role in the early phases of an immune response to respiratory viruses. AMs are likely the first immune cells to encounter SARS‐CoV‐2 during an infection, and their reaction to the virus will have a profound impact on the outcome of the infection. Interferons (IFNs) are antiviral cytokines and among the first cytokines produced upon viral infection. In this study, AMs from non‐infectious donors are challenged with SARS‐CoV‐2. We demonstrate that challenged AMs are incapable of sensing SARS‐CoV‐2 and of producing an IFN response in contrast to other respiratory viruses, like influenza A virus and Sendai virus, which trigger a robust IFN response. The absence of IFN production in AMs upon challenge with SARS‐CoV‐2 could explain the initial asymptotic phase observed during COVID‐19 and argues against AMs being the sources of pro‐inflammatory cytokines later during infection.
Regional Variation in Genetic Control of Atherosclerosis in Hyperlipidemic Mice
Authors: Jones Michael B , An Alexander , Shi Lisa J , Shi Weibin 
Published: October 2020

AbstractAtherosclerosis is a polygenic disorder that often affects multiple arteries. Carotid arteries are common sites for evaluating subclinical atherosclerosis, and aortic root is the standard site for quantifying atherosclerosis in mice. We compared genetic control of atherosclerosis between the two sites in the same cohort derived from two phenotypically divergent Apoe-null (Apoe−/−) mouse strains. Female F2 mice were generated from C57BL/6 (B6) and C3H/He (C3H) Apoe−/− mice and fed 12 weeks of Western diet. Atherosclerotic lesions in carotid bifurcation and aortic root and plasma levels of fasting lipids and glucose were measured. 153 genetic markers across the genome were typed. All F2 mice developed aortic atherosclerosis, while 1/5 formed no or little carotid lesions. Genome-wide scans revealed 3 significant loci on chromosome (Chr) 1, Chr15, 6 suggestive loci for aortic atherosclerosis, 2 significant loci on Chr6, Chr12, and 6 suggestive loci for carotid atherosclerosis. Only 2 loci for aortic lesions showed colocalization with loci for carotid lesions. Carotid lesion sizes were moderately correlated with aortic lesion sizes (r = 0.303; P = 4.6E-6), but they showed slight or no association with plasma HDL, non-HDL cholesterol, triglyceride, or glucose levels among F2 mice. Bioinformatics analyses prioritized Cryge as a likely causal gene for Ath30, Cdh6 and Dnah5 as causal genes for Ath22. Our data demonstrate vascular site-specific effects of genetic factors on atherosclerosis in the same animals and highlight the need to extend studies of atherosclerosis to sites beyond aortas of mice.
A COVID–19-járvány alatti betegelégedettség egy sürgősségi betegellátó osztályon
Authors: Deák András , Fusz Katalin , Kanizsai Péter 
Published: October 2020

Absztrakt:
Bevezetés és célkitűzés: A nagy betegszám a sürgősségi
osztályokon a dolgozók megterhelését növeli, a betegelégedettséget csökkenti.
Ennek a tendenciának megállítására és javítására több módszert is bevezettünk
2019-ben. A COVID–19-járvány során a betegek a sürgősségi osztályt keresték fel
azon panaszaikkal, amelyekkel amúgy a háziorvost vagy a szakambulanciákat
keresték volna fel, továbbá a szakdolgozók több mint 15%-a a Koronavírus Ellátó
Központban dolgozott 2020. áprilisban és májusban. Célunk volt felmérni a
2019-ben bevezetett intézkedéseknek, valamint a COVID–19-járvány okozta
pluszmegterhelésnek a betegelégedettségre gyakorolt hatásait.
Módszer: Longitudinális, kvantitatív, leíró jellegű,
kérdőíves felmérést és dokumentumelemzést végeztünk a Pécsi Tudományegyetem
Klinikai Központ (PTE KK) Sürgősségi Orvostani Tanszékének Sürgősségi
Betegellátó Osztályán 2019. április 1. és 2020. május 31. között (n = 999). A
felmérés első részében 354, a második részében 645 kérdőívet elemeztünk,
valamint a dokumentumelemzés során a betegszámokat használtuk fel. Az
adatelemzéshez leíró statisztikát, kétmintás t-próbát és Mann–Whitney-tesztet
végeztünk (p<0,05). Eredmények: A felmérés első hónapjában a
páciensek és hozzátartozók 51%-a értékelte pozitívan a PTE KK Sürgősségi
Orvostani Tanszékének Sürgősségi Betegellátó Osztályát, míg novemberre ez az
arány 99%-ra emelkedett. A kommunikációs tréninget és egyéb intézkedéseket
követően pozitív irányba változott az ápolókról (Z = –2,25, p = 0,024), az
orvosokról (Z = –2,25, p = 0,024) és az osztályról (Z = –2,24, p = 0,025)
alkotott vélemény. A COVID–19-járvány alatt csökkent a betegelégedettség: a
dolgozók viselkedését (Z = –4,16, p<0,001) és a szolgáltatások minőségét (Z =
–3,88, p<0,001) is rosszabbnak ítélték. Következtetés: A
bevezetésre került intézkedéseink pozitív hatásait mérhetjük a betegelégedettség
növekedésén keresztül. Eredményeink rámutatnak arra, hogy a COVID–19-járvány
miatti dolgozói megterhelés negatívan befolyásolta a betegelégedettséget. Orv
Hetil. 2020; 161(43): 1819–1823.