bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do Shareholders Fight for Firm Value or Market Value in Emerging Markets? The Mediating Effect of Board Structure Dynamics on Dividend Policy Decision
Authors: Ofori‐Sasu Daniel , Abor Joshua Yindenaba , Quaye Sydney 
Published: December 2019

AbstractThe paper examines the mediating effect of board structure dynamics on the relationship between dividend payout and shareholders’ wealth at the firm level and market level. Panel regression models are used by applying data from 27 listed firms in Ghana between 2010 and 2017. We find that board structure dynamics have a direct effect on shareholders’ wealth at both levels. However, the results reveal new evidence that board structure dynamics play a mediating role on the relationship between dividend policy decision and shareholders’ wealth only at the market level. We find that independent directors and CEO duality significantly reduce market value of shareholders through dividend payout decision. However, independent directors and longer CEO tenure in office mediate a positive effect on the relationship between dividend policy and shareholders’ wealth at the market level. Thus, the mediating effect of board structure dynamics, particularly independent directors and CEO tenure, are important in predicting a positive relationship between dividend policy and shareholders’ wealth at the market level than at the firm level. Therefore, regulatory bodies and investors should provide strong board structure dynamics that serve as a mediating mechanism for prudent dividend policy decisions that add value to shareholders’ wealth.
Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment
Authors: Quarles Ellen , Basisty Nathan , Chiao Ying Ann , Merrihew Gennifer , Gu Haiwei , Sweetwyne Mariya T. , Fredrickson Jeanne , Nguyen Ngoc‐Han , Razumova Maria , Kooiker Kristina , Moussavi‐Harami Farid , Regnier Michael , Quarles Christopher , MacCoss Michael , Rabinovitch Peter S. 
Published: December 2019

AbstractEven in healthy aging, cardiac morbidity and mortality increase with age in both mice and humans. These effects include a decline in diastolic function, left ventricular hypertrophy, metabolic substrate shifts, and alterations in the cardiac proteome. Previous work from our laboratory indicated that short‐term (10‐week) treatment with rapamycin, an mTORC1 inhibitor, improved measures of these age‐related changes. In this report, we demonstrate that the rapamycin‐dependent improvement of diastolic function is highly persistent, while decreases in both cardiac hypertrophy and passive stiffness are substantially persistent 8 weeks after cessation of an 8‐week treatment of rapamycin in both male and female 22‐ to 24‐month‐old C57BL/6NIA mice. The proteomic and metabolomic abundance changes that occur after 8 weeks of rapamycin treatment have varying persistence after 8 further weeks without the drug. However, rapamycin did lead to a persistent increase in abundance of electron transport chain (ETC) complex components, most of which belonged to Complex I. Although ETC protein abundance and Complex I activity were each differentially affected in males and females, the ratio of Complex I activity to Complex I protein abundance was equally and persistently reduced after rapamycin treatment in both sexes. Thus, rapamycin treatment in the aged mice persistently improved diastolic function and myocardial stiffness, persistently altered the cardiac proteome in the absence of persistent metabolic changes, and led to persistent alterations in mitochondrial respiratory chain activity. These observations suggest that an optimal translational regimen for rapamycin therapy that promotes enhancement of healthspan may involve intermittent short‐term treatments.
Balancing act: modelling sustainable release numbers for translocations
Authors: Easton L. J. , Bishop P. J. , Whigham P. A. 
Published: December 2019

AbstractTranslocated populations often share demographic, environmental and genetic risks associated with relict populations. Models that predict translocation impacts on source and founder populations are therefore necessary to ensure that harvesting for release does not jeopardize either population. However, current models generally focus on maximizing the long‐term demographic viability and retention of allelic diversity in the founder population only. We therefore risk estimating a release number that is considered ‘appropriate' for maintaining viability and allelic diversity in the founder population but is in fact detrimental to the source. Our objectives were to determine a sustainable number of individuals for release that maximized the viability and allelic diversity of source and founder populations. We developed a spatially explicit individual‐based model that simulated hypothetical translocation scenarios for the threatened New Zealand frog, Leiopelma pakeka, which was restricted to Te Hoiere/Maud Island and has been heavily targeted for translocations. Source and translocated populations were simulated over 200 generations, representing 200 years across various initial population sizes from 20 to 300 frogs. To account for the potential loss of allelic diversity from the source population via harvesting, along with genetic drift and founder events typically associated with translocations, an additional set of simulations determined the probability of retaining a single diploid locus within populations with rare and common alleles. Our results showed that at least 120 frogs were required for populations to remain viable and maximize allelic retention in the long‐term, regardless of allelic diversity. However, harvesting more than 150 frogs led to ongoing or the onset of declines in the viability and allelic retention of source populations. We recommend that future translocations of L. pakeka harvest no more than 140 frogs from each of the sub‐populations on Te Hoiere/Maud Island. We also recommend the described approach to simulate hypothetical translocation scenarios for other managed species.
First year allied health student transition to a regional university
Authors: Gray Marion , Gordon Susan , O’Neill Maureen , Pearce Wendy M. 
Published: December 2019

AbstractObjectiveStudents from regional and remote backgrounds are more likely to stay and work in regional and remote locations. Health students transition and retention at university impacts the retainment of a competent rural health workforce. This study aimed to examine the perceptions of allied health students as they reflected upon their first six weeks at university and identified strategies which enhanced these experiences.DesignA cross‐sectional study. Surveys were administered to students who then completed a reflection exercise. Data were analysed using Pearson correlation coefficient and chi‐squares.SettingAn Australian regional university.ParticipantsFirst year occupational therapy, physiotherapy and speech pathology students.Main outcome measuresFactors influencing the first 6 weeks at university.ResultsOne hundred and forty‐three students participated. Homesickness was the major challenge in transitioning to university life. Subthemes identified were adjusting to being away from home, adjusting to university culture and the mature‐aged student. Specific issues included a lack of familiarity with university campuses and services, being unprepared for the workload and confusion while learning new skills.ConclusionOrientation week activities assist students transition into university and age‐appropriate and family‐friendly activities should be considered for mature‐age students. All students were found to benefit from support to address economic pressures and skill development focusing on coping with university workload. The development of regional university policy including these strategies is likely to enhance student success.
Progression of incomplete toward complete left bundle branch block: A clinical and electrocardiographic analysis
Authors: Senesael Ellie , Calle Simon , Kamoen Victor , Stroobandt Roland , De Buyzere Marc , Timmermans Frank , De Pooter Jan 
Published: December 2019

AbstractBackgroundComplete left bundle branch block (cLBBB) is associated with increased cardiovascular mortality and heart failure. On the contrary, the clinical relevance of incomplete left bundle branch block (iLBBB) is less known. This study investigated the profile and outcome of iLBBB patients and assessed the risk of progression to cLBBB.MethodsPatients diagnosed with iLBBB between July 2013 and April 2018 were retrospectively included. Subsequently, echo‐ and electrocardiographic examinations at time of iLBBB diagnosis and during follow‐up, as well as progression to non‐strict cLBBB and strict cLBBB, were evaluated.ResultsThe study enrolled 321 patients (33% female, age 74 ± 11 years). During the follow‐up of 21 (8;34) months, 33% of iLBBB patients evolved to non‐strict cLBBB and 27% to strict cLBBB. iLBBB patients who evolved to non‐strict or strict cLBBB were older, had more frequently reduced left ventricular ejection fraction, and had more often QRS notching/slurring in the lateral leads and inferior leads, compared to patients without progression to cLBBB. In multivariate analysis, only QRS notching/slurring in the lateral leads was independently associated with progression to non‐strict cLBBB (odds ratio 4.64, p < .001) and strict cLBBB (odds ratio 9.6, p < .001). iLBBB patients with QRS notching/slurring had a progression rate to non‐strict cLBBB of 52% and 49% to strict cLBBB.ConclusionAmong patients with iLBBB, up to one third of the patients progress to cLBBB within a period of 2 years. The presence of QRS notching/slurring in the lateral leads during iLBBB was the strongest predictor for progression toward cLBBB.
A case of gastric cancer after sleeve gastrectomy
Authors: Yamashita Takeshi , Tan Jeremy , Lim Eugene , Eng Alvin , Ong Hock S , Chan Weng H 
Published: December 2019

AbstractThere is concern over how to survey the remnant upper gastrointestinal tract, as well as what to do if a patient subsequently develops an upper gastrointestinal cancer following bariatric surgery. We hereby report a case of gastric cancer arising 8 years after a laparoscopic sleeve gastrectomy (LSG). The patient, a 42 year‐old woman, was diagnosed with a gastric cancer via esophagogastroduodenoscopy (EGD). As such, she underwent a laparoscopic total gastrectomy with lymphadenectomy. The final histopathology was that of a poorly differentiated adenocarcinoma with signet‐ring cells without lymph node metastases (staging pT4aN0). The background gastric mucosa displayed no Helicobacter pylori. There have only been a few reported cases of gastric cancer after sleeve gastrectomy. Nevertheless, it may be wise to consider performing EGD at regular intervals after bariatric surgery, especially in Asia. In this regard, LSG holds an advantage over Roux‐en‐Y gastric bypass with respect to the feasibility of surveillance of the remnant stomach.
Angels and devils?: How do benevolent and authoritarian leaders differ in shaping ethical climate via justice perceptions across cultures?
Authors: Gumusluoglu Lale , Karakitapoğlu‐Aygün Zahide , Hu Changya 
Published: December 2019

AbstractThe current study examines the effects of two major dimensions of Paternalistic Leadership (PL), authoritarian and benevolent leadership, on the perceived workplace ethical climate in different cultural contexts. Based on social influence and organizational justice theories, we illuminate the processes underlying the effects of these leadership styles on ethical climate by proposing perceived procedural and interactional justice as potential mediators. We also test how these mediating effects vary in three different countries: Taiwan, Turkey, and the United States. Based on a sample of 674 Taiwanese, 409 Turkish, and 479 American employees, we identified several interesting mediation and moderation results on leadership‐justice‐ethical climate paths. To our surprise, while procedural justice was an important mechanism linking benevolent leadership and ethical climate in all three countries, it mediated the relationship between authoritarian leadership and ethical climate only in Turkey. However, interactional justice was found to be a significant mediating mechanism only in the United States and for both authoritarian and benevolent leadership. In addition, cultural context moderated the PL‐justice link such that the strongest positive benevolent leadership and interactional justice relationship, as well as the strongest negative association between authoritarian leadership and both types of justice, were observed in Turkey.
Promotion of the Warburg effect is associated with poor benefit from adjuvant chemotherapy in colorectal cancer
Authors: Kitazawa Masashi , Hatta Tomohisa , Sasaki Yusuke , Fukui Kazuhiko , Ogawa Koji , Fukuda Eriko , Goshima Naoki , Okita Natsuko , Yamada Yasuhide , Nakagama Hitoshi , Natsume Tohru , Horimoto Katsuhisa 
Published: December 2019

AbstractMetabolic reprogramming, including the Warburg effect, is a hallmark of cancer. Indeed, the diversity of cancer metabolism leads to cancer heterogeneity, but accurate assessment of metabolic properties in tumors has not yet been undertaken. Here, we performed absolute quantification of the expression levels of 113 proteins related to carbohydrate metabolism and antioxidant pathways, in stage III colorectal cancer surgical specimens from 70 patients. The Warburg effect appeared in absolute protein levels between tumor and normal mucosa specimens demonstrated. Notably, the levels of proteins associated with the tricarboxylic citric acid cycle were remarkably reduced in the malignant tumors which had relapsed after surgery and treatment with 5‐fluorouracil‐based adjuvant therapy. In addition, the efficacy of 5‐fluorouracil also decreased in the cultured cancer cell lines with promotion of the Warburg effect. We further identified nine and eight important proteins, which are closely related to the Warburg effect, for relapse risk and 5‐fluorouracil benefit, respectively, using a biomarker exploration procedure. These results provide us a clue for bridging between metabolic protein expression profiles and benefit from 5‐fluorouracil adjuvant chemotherapy.
Optimization of capture–recapture monitoring of elusive species illustrated with a threatened grasshopper
Authors: Bröder Linda , Tatin Laurent , Hochkirch Axel , Schuld Andreas , Pabst Lucas , Besnard Aurélien 
Published: December 2019

AbstractInformation on population sizes and trends of threatened species is essential for their conservation, but obtaining reliable estimates can be challenging. We devised a method to improve the precision of estimates of population size obtained from capture–recapture studies for species with low capture and recapture probabilities and short seasonal activity, illustrated with population data of an elusive grasshopper (Prionotropis rhodanica). We used data from 5 capture–recapture studies to identify methodological and environmental factors affecting capture and recapture probabilities and estimates of population size. In a simulation, we used the population size and capture and recapture probability estimates obtained from the field studies to identify the minimum number of sampling occasions needed to obtain unbiased and robust estimates of population size. Based on these results we optimized the capture–recapture design, implemented it in 2 additional studies, and compared their precision with those of the nonoptimized studies. Additionally, we simulated scenarios based on thresholds of population size in criteria C and D of the International Union for Conservation of Nature (IUCN) Red List to investigate whether estimates of population size for elusive species can reliably inform red‐list assessments. Identifying parameters that affect capture and recapture probabilities (for the grasshopper time since emergence of first adults) and optimizing field protocols based on this information reduced study effort (−6% to −27% sampling occasions) and provided more precise estimates of population size (reduced coefficient of variation) compared with nonoptimized studies. Estimates of population size from the scenarios based on the IUCN thresholds were mostly unbiased and robust (only the combination of very small populations and little study effort produced unreliable estimates), suggesting capture–recapture can be considered reliable for informing red‐list assessments. Although capture–recapture remains difficult and costly for elusive species, our optimization procedure can help determine efficient protocols to increase data quality and minimize monitoring effort.
Mechanisms in fluid retention – towards a mutual concept
Authors: Mottelson Mathis N. , Lundsgaard Christoffer C. , Møller Søren 
Published: December 2019

SummaryFluid retention is a common and challenging condition in daily clinical practice. The normal fluid homoeostasis in the human body is based on accurately counter‐balanced physiological mechanisms. When compromised fluid retention occurs and is seen in pathophysiologically different conditions such as liver cirrhosis, heart and kidney failure, and in preeclampsia. These conditions may share pathophysiological mechanisms such as functional arterial underfilling, which seems to be a mutual element in cirrhosis, cardiac failure, cardiorenal and hepatorenal syndromes, and in pregnancy. However, there are also distinct differences and it is still unclear whether kidney dysfunction or arterial underfilling is the initiating factor of fluid retention or if they happen simultaneously. This review focuses on similarities and differences in water retaining conditions and points to areas where important knowledge is still needed.
A pragmatic approach for comparing species distribution models to increasing confidence in managing piping plover habitat
Authors: Maslo Brooke , Zeigler Sara L. , Drake Evan C. , Pover Todd , Plant Nathaniel G. 
Published: December 2019

AbstractConservation management often requires decision‐making without perfect knowledge of the at‐risk species or ecosystem. Species distribution models (SDMs) are useful but largely under‐utilized due to model uncertainty. We used an ensemble modeling approach of two independently derived SDMs to explicitly address common modeling impediments and directly inform conservation decision‐making for piping plovers in a heavily populated mid‐Atlantic (USA) coastal zone. We summarized previously published Bayesian network and maximum entropy models to highlight similarities and differences in structure, and we compared the relative importance of predictors used. Despite differences in analytical approach, relative importance of factors driving nest‐site selection was consistent. Models demonstrated considerable agreement when comparing a binary (suitable/unsuitable) measure of suitability. Instances of model consensus (i.e., overlapping areas of predicted piping plover nesting habitat between models) provide a stronger “signal” in model results, reducing uncertainty related to biases or errors associated with either model. We tested model accuracy using a common dataset of plover nests initiated within the focal areas between 2013 and 2015, and we examined congruency in model outputs. Nearly, 90% of all nests occurred in areas predicted suitable by at least one model, and at least 33% of the total nests were predicted in areas suitable by both. Because models predominantly agreed on what drives piping plover nest‐site selection, areas predicted suitable by a single model should not be discounted. This case study demonstrates how models can effectively inform conservation planning by explicitly identifying the management objective, presenting robust evidence to allow managers to evaluate outcomes of alternative management decisions, and clearly communicating results that address real‐world conservation problems. Our results can greatly increase the piping plover management community's ability to prioritize candidate sites for future protection, manage existing nesting habitat appropriately, and make a compelling case for conservation actions against competing land use objectives.
Gender gaps in cognitive and social‐emotional skills in early primary grades: Evidence from rural Indonesia
Authors: Nakajima Nozomi , Jung Haeil , Pradhan Menno , Hasan Amer , Kinnell Angela , Brinkman Sally 
Published: December 2019

AbstractThis paper examines the magnitude and source of gender gaps in cognitive and social‐emotional skills in early primary grades in rural Indonesia. Relative to boys, girls score more than 0.17 SD higher in tests of language and mathematics (cognitive skills) and between 0.18 and 0.27 SD higher in measures of social competence and emotional maturity (social‐emotional skills). We use Oaxaca–Blinder decomposition to investigate the extent to which gender differences in early schooling and parenting practices explain these gender gaps in skills. For cognitive skills, differences in early schooling between boys and girls explain between 9% and 11% of the gender gap whereas differences in parenting practices explain merely 3%–5% of the gender gap. This decomposition result is driven largely by children living in villages with high‐quality preschools. In contrast, for social‐emotional skills, differences in parenting styles toward boys and girls explain between 13% and 17% of the gender gap, while differences in early schooling explain only 0%–6% of the gender gap.
von Willebrand Disease and other hereditary haemostatic factor deficiencies in women with a history of postpartum haemorrhage
Authors: Majluf‐Cruz Karim , Anguiano‐Robledo Liliana , Calzada‐Mendoza Claudia C. , Hernández‐Juárez Jesús , Moreno‐Hernández Manuel , Domínguez‐Reyes Víctor Manuel , Figueroa‐Torres Anahi Guadalupe , Gomez‐Rosas Patricia , Arreola‐Diaz Rodrigo , García‐Lee María Teresa , Ricardo‐Moreno María Tania , Sosa‐Camas Rosa Elena , Garcia‐Chavez Jaime , Vela Ojeda Jorge , Isordia‐Salas Irma , Majluf‐Cruz Abraham 
Published: December 2019

AbstractIntroductionPostpartum haemorrhage (PPH) is the main cause of maternal morbidity and mortality globally, but it is far more important in non‐developed countries. PPH represents 25% of all maternal deaths worldwide. Women with von Willebrand disease (VWD) and other inherited haemorrhagic disorders are at increased risk of PPH. Our aim was to establish a probable association of severe PPH in women with a history of haemostatic abnormalities.MethodsAn observational, controlled study of adult women with a one or more episodes of severe PPH requiring treatment in an intensive care unit or >10 units of blood products during the 24‐hour period after diagnosis and their controls. The tests performed were blood cell count, blood group, renal, viral, liver function and haemostatic tests, fibrinogen, activity of the plasma factors and specific test to diagnose and classify VWD.ResultsWe included 124 women with 133 PPH events and their controls. The median age at the first event was 25.5 years old. Results were significantly different between the groups in terms of fibrinogen concentration, VWF:Ag, VWF:RCo and FVIII. A specific diagnosis was established in 69 (55.6) and 4 (3.2%) patients in the PPH group and controls, respectively. Of 61 patients with VWD, 57 had type 1, two had type 2A, and another two had type 2B.ConclusionOur results show a relationship between PPH and inherited haemostatic disorders. VWD was the most frequent diagnosis. Appropriate and opportune diagnosis before pregnancy of inherited haemostatic disorders may be important to effectively prevent and treat PPH.