bluuebunny/crossref_metadata_2025_split huggingface dataset:
The predictive value of diaphragm ultrasound for weaning outcomes in critically ill children
Authors: Xue Yang , Zhang Zhen , Sheng Chu-Qiao , Li Yu-Mei , Jia Fei-Yong 
Published: November 2019

Abstract
Background: Multiple studies have shown that diaphragmatic ultrasound can better predict the outcome of weaning in adults. However, there are few studies focusing on children, leading to a lack of sufficient clinical evidence for the application of diaphragmatic ultrasound in children. The purpose of this study was to investigate the predictive value of diaphragm ultrasound for weaning outcomes in critically ill children.
Methods: The study included 50 cases whose mechanical ventilation (MV) time was >48 h, and all eligibles were divided into either the weaning success group (n = 39) or the weaning failure group (n = 11). Diaphragm thickness, diaphragmatic excursion (DE), and diaphragmatic thickening fraction (DTF) were measured in the zone of apposition. The maximum inspiratory pressure (PImax) was also recorded.
Results: The ventilatory treatment time (P = 0.002) and length of PICU stay (P = 0.013) in the weaning failure group was longer than the success group. Cut-off values of diaphragmatic measures associated with successful weaning were ≥21% for DTF with a sensitivity of 0.82 and a specificity of 0.81, whereas it was ≥0.86 cm H2O/kg for PImax with a sensitivity of 0.51 and a specificity of 0.82. The linear correlation analysis showed that DTF had a significant positive correlation with PImax in children (P = 0.003).
Conclusions: Diaphragm ultrasound has potential value in predicting the weaning outcome of critically ill children. DTF and PImax presented better performance than other diaphragmatic parameters. However, DE has limited value in predicting weaning outcomes of children with MV.
Molecular cytogenetics of valuable Arctic and sub-Arctic pasture grass species from the Aveneae/Poeae tribe complex (Poaceae)
Authors: Amosova Alexandra V. , Zoshchuk Svyatoslav A. , Rodionov Alexander V. , Ghukasyan Lilit , Samatadze Tatiana E. , Punina Elizaveta O. , Loskutov Igor G. , Yurkevich Olga Yu. , Muravenko Olga V. 
Published: November 2019

Abstract
Grasslands in the Arctic tundra undergo irreversible degradation due to climatic changes and also over-exploitation and depletion of scarce resources. Comprehensive investigations of cytogenomic structures of valuable Arctic and sub-Arctic grassland species is essential for clarifying their genetic peculiarities and phylogenetic relationships, and also successful developing new forage grass cultivars with high levels of adaptation, stable productivity and longevity. We performed molecular cytogenetic characterization of insufficiently studied pasture grass species (Poaceae) from related genera representing two neighboring clades: 1) Deschampsia and Holcus; 2) Alopecurus, Arctagrostis and Beckmannia, which are the primary fodder resources in the Arctic tundra.
Didelphis albiventris: an overview of an unprecedented transcriptome sequencing of the white-eared opossum
Authors: Santos Íria Gabriela Dias dos , Mendes Tiago Antônio de Oliveira , Silva Gerluza Aparecida Borges , Reis Amanda Maria Sena , Vitorello Cláudia Barros Monteiro , Schaker Patrícia Dayane Carvalho , Herai Roberto Hirochi , Fabotti André Brait Carneiro , Coutinho Luiz Lehmann , Jorge Erika C 
Published: November 2019

Abstract
BackgroundThe white-eared opossum (Didelphis albiventris) is widely distributed throughout Brazil and South America. It has been used as an animal model for studying different scientific questions ranging from the restoration of degraded green areas to medical aspects of Chagas disease, leishmaniasis and resistance against snake venom. As a marsupial, D. albiventris can also contribute to the understanding of the molecular mechanisms that govern the different stages of organogenesis. Opossum joeys are born after only 13 days, and the final stages of organogenesis occur when the neonates are inside the pouch, depending on lactation. As neither the genome of this opossum species nor its transcriptome has been completely sequenced, the use of D. albiventris as an animal model is limited. In this work, we sequenced the D. albiventris transcriptome by RNA-seq to obtain the first catalogue of differentially expressed (DE) genes and gene ontology (GO) annotations during the neonatal stages of marsupial development.ResultsThe D. albiventris transcriptome was obtained from whole neonates harvested at birth (P0), at five days of age (P5) and at ten days of age (P10). The de novo assembly of these transcripts generated 85,338 transcripts. Approximately 30% of these transcripts could be mapped against the amino acid sequences of M. domestica, the evolutionarily closest relative of D. albiventris to be sequenced thus far. Among the expressed transcripts, 2,077 were found to be DE between P0 and P5, 13,780 between P0 and P10, and 1,453 between P5 and P10. The enriched GO terms were mainly related to the immune system, blood tissue development and differentiation, vision, hearing, digestion, the CNS and limb development.ConclusionsThe elucidation of opossum transcriptomes provides an out-group for better understanding the distinct characteristics associated with the evolution of mammalian species. This study provides the first transcriptome sequences and catalogue of genes for a marsupial species at different neonatal stages, allowing the study of the mechanisms involved in organogenesis.
The efficacy of iCBT added to treatment as usual for alcohol dependent patients in Primary Care: study protocol for a randomized controlled trial.
Authors: Hyland Karin , Hammarberg Anders , Hedman-Lagerlöf Erik , Johansson Magnus , Andreasson Sven 
Published: November 2019

Abstract
Introduction

Alcohol dependence is a common disorder with a continuum regarding severity. Most alcohol dependent persons have a moderate level of dependence and live under socially orderly conditions. Treatment seeking in this group is low, mainly due to stigma and because treatment options are seen as unappealing. Alcohol is a relevant topic to discuss in many primary care (PC) consultations and PC is less stigmatizing to visit compared to addiction care units for people with alcohol problems. General practitioners (GP) hesitate to engage in treating alcohol problems due to time constraints and lack of knowledge. Screening and brief interventions are effective for high consumers but there are few studies on dependence.

Methods

This is a two-group, parallel, randomized controlled trial (RCT). The aim is to study whether an Internet based Cognitive Behavioral Treatment (iCBT) when added to treatment as usual (TAU) is more effective than TAU only for alcohol dependence in PC. 260 adults with alcohol dependence will be included. Participants are randomized to iCBT and TAU or TAU only. The primary study outcome is alcohol consumption in grams per week and heavy drinking days. Secondary outcomes include alcohol related problem severity, number of diagnostic criteria for alcohol dependence, depression and anxiety symptoms, health related quality of life and biochemical markers for high consumption and liver pathology. Data will be analyzed using mixed-effect models.

Discussion

Internet based interventions are attractive to and have been shown to reach people with alcohol problems. Yet there are no studies investigating the efficacy of internet treatment of alcohol dependence in PC. In this study we hypothesize that iCBT when added to TAU will improve treatment outcome for alcohol dependence in PC, compared to TAU only. If effective, iCBT can be distributed to the public to a low cost for a stakeholder and has the opportunity to reduce both short term and long-term public health costs.
Trial registration: ISRCTN69957414. Retrospectively registered 07/06/2018. http://www.isrctn.com/ISRCTN69957414
Utilization of dental services and associated factors among preschool children in China
Authors: Gao Xiaoli , Ding Min , Xu Mengru , Wu Huijing , Zhang Chunzi , Wang Xing , Feng Xiping , Tai Baojun , Hu Deyu , Lin Huancai , Wang Bo , Zheng Shuguo , Liu Xuenan , Rong Wensheng , Wang Weijian , Wang Chunxiao , Si Yan 
Published: November 2019

Abstract
Background: This study sought to evaluate dental utilization among 3-,4-, and 5-year-old children in China and to use Andersen’s behavioural model to explore influencing factors, thereby providing a reference for future policy making.
Methods: This study is a cross-sectional study. Data of 40,305 children aged 3-5 years were extracted from the Fourth National Oral Health Survey, which was performed from August 2015 to December 2016.Patient data were collected using a questionnaire, whichwas answered by the child’s parents, and clinical data were collected during a clinical examination. Stratification and survey weighting were incorporated into the complex survey design. Descriptive statistics, bivariate correlations and hierarchicallogistic regression results were then analysed to find the factors associated with oral health service utilization.
Results : The oral health service utilization prevalenceduring the prior 12 months were 9.5% (95%CI: 8.1%-11.1%) among 3-year-old children, 12.1% (95%CI: 10.8%-13.5%) among 4-year-old children, and 17.5% (95%CI: 15.6%-19.4%) among 5-year-old children. “No dental diseases” (71.3%) and “dental disease was not severe” (12.4%) were the principal reasons why children had not attended a dental visit in the past 12 months. The children whose parents had a bachelor’s degree or higher(OR: 2.29, 95%CI: 1.97-2.67, p <0.001), a better oral health attitude ranging from 5 to 8(OR: 1.64, 95%CI: 1.43-1.89, p <0.001), annual per capital income more than 25,000RMB (OR: 1.40, 95%CI: 1.18-1.65, p <0.001),think their child have worse or bad oral health(OR: 3.54, 95%CI: 2.84-4.40, p <0.001), and children who often have toothaches (OR: 9.72 , 95%CI: 7.81-12.09, p <0.001) were more likely to go to the dentist in the past year.
Conclusion: The prevalenceof dental service utilization was relatively low among preschool children. It is necessary to strengthen oral health education for parents and children, thereby improving oral health knowledge as well as attitude, and promoting dental utilization.
A non-randomized chlinical trial The effect of pelvic floor exercises at home and electrical stimulation plus biofeedback in hospital in management of stress urinary incontinence of primiparas in short-term postpartum period
Authors: Tang Fei , Zhao Yun , Sun Guo-qiang , Lin Ying , Tang Wan 
Published: November 2019

Abstract
Background To investigate the effect of pelvic floor exercises at home and electrical stimulation plus biofeedback in hospital in management of stress urinary incontinence (SUI) primiparas in short-term postpartum period. Methods A total of 150 SUI primiparas at postpartum 6-8 weeks were interviewed. According to participants’ willingness and necessary coordination, the subjects were divided into 2 groups including the treatment group (n=69) and the control group (n=81). The treatment group received at-home pelvic floor muscle training(PFMT) every day and in-hospital electrical stimulation plus biofeedback therapy twice a week for consecutive 5 weeks (from 6-8 postpartum weeks to 11-13 postpartum weeks). The control group was not given pelvic floor exercise at home or in hospital. The PFM strength in the two groups was measured by specially trained personnel using digital palpation (Modified Oxford scale:0-5 grade) and surface electromyography(sEMG) in 6-8 postpartum weeks and in 11-13 postpartum weeks. For statistical analysis, t -test,Chi-square analysis and Wilcoxon test were carried out. Results The recovery rate of SUI in the treatment group was 63.8% (44/69), which was higher than that in the control group (12.3%,10/81) ( p <0.05). In the treatment group, the PFM strength was higher after PFMT than that before PFMT no matter measured by digital palpation or by sEMG ( p <0.05); but in the control group, it had no change at postpartum 6-8 weeks and at postpartum about 12 weeks ( p >0.05). Conclusion: The combination treatment of at-home PFM training and in-hospital electrical stimulation plus biofeedback PFM therapy is an effective method to manage SUI and improve PFM strength in short-time postpartum.
"SLOW": an effective strategy for treating suspected gastroesophageal reflux cough
Authors: Ding Meiling , Wang Guangqiang , Wu Liqun , Liu Baoyi , Zhang Wei , Song Xiaojie 
Published: November 2019

Abstract
Background Patients with gastroesophageal reflux cough were always given drugs treatment to relieve symptoms. But most of these patients were found to have unhealty diatery habits. To develop a new strategy to assist drugs therapy, the study was conducted. Objective To explore the clinical significance of “SLOW” strategy in the treatment of suspected gastroesophageal reflux cough. Methods A prospective study was conducted to select 122 patients diagnosed with chronic cough and suspected with gastroesophageal reflux cough who were admitted to Qilu hospital of Shandong University (Qingdao) from January 2015 to December 2017. Patients were randomly divided into experimental group (n=72) and control group (n=50). The experimental group was given omeprazole 20mg bid po + domperidone 10mg tid po + “SLOW” strategy, while the control group was only given omeprazole 20mg bid po + domperidone 10mg tid po. Hsu cough scoring system was used to analyze and evaluate the efficacy after 4 weeks of treatment. Results Among the 72 patients in the experimental group, 56 were effective (77.8 %), of which 44 cases were completely alleviated (61.1 %). Of the 50 control group patients, 27 were effective (54.0 %), of which 19 were in complete remission (38.0 %). The Hsu cough score showed a significant decrease in the scores of the experimental group, which was statistically significant compared with that of the control group (P<0.05). Conclusion The “SLOW” strategy, as a supplement to drug therapy, can increase the efficiency of treatment and significantly reduce the Hsu cough score.
Transcultural validation of the Return-to-Work Self-Efficacy Scale in Korean patients with work-related injuries
Authors: Lee Jeong-Eun , Yoo Su Bin , leigh Ja-ho 
Published: November 2019

Abstract
Background : This study aimed to develop a Korean-language version of the RTWSE-19 through a forward and backward translation process and to investigate the validity of the Return-to-Work Self-Efficacy Scale specifically for Asian workers with work-related injuries.Methods : Participants were 202 injured workers who had filed a claim accepted by the workers’ compensation system following a work-related musculoskeletal injury. Among participants, 88.1% were male, 54.5% were over 45 years, 45.5% had an occupation in manufacturing, and 54.5% were craft or machine operator and assemblers. Results : Using exploratory factor analysis, three factors with 17 items were identified: (i) meeting job demands, (ii) modifying job tasks, and (iii) communicating needs to others. Removal of two item in modifying job tasks domain resulted in an increased reliability. The Korean version of the RTWSE-17 showed reasonable model fit (CFI = .963; TLI = .943; RMSEA = .068; SRMR = 0.029), satisfactory reliability (r = 0.925), no floor and ceiling effect, and construct validity.Conclusions : The scale was found to possess good psychometric properties and could address different injury types ranging from fractures to amputations involved in sub-acute and rehabilitation phases in a Korean context. The results from this study provide practitioners and researchers with insight into return to work after rehabilitation in Asian clinical and workplace setting.
Experiences, views and needs of first-time fathers in pregnancy related care: a qualitative study in south-east Nigeria.
Authors: Onyeze-Joe Chiemeka , Godin Isabelle 
Published: November 2019

Abstract
Background Given the importance of paternal involvement in maternal care, there is need to prepare first-time fathers to actively participate in pregnancy and childbirth in Nigeria. This study explores the experiences and needs of first-time fathers and the influence of these on their involvement during pregnancy and childbirth in Nigeria. Methods Semi structured interviews were conducted with 50 men recruited from workplaces, health centers, and markets in rural and urban settings in south-east Nigeria. Using an interview guide, questions were asked to explore the needs of first-time fathers and understand how their needs influenced their involvement during pregnancy and childbirth. Data was transcribed and analysed using thematic content analysis. Results Six major themes were identified pertaining to the experiences and needs of male partners experiencing pregnancy and childbirth for the first time. Inexperience, cultural beliefs and perception of gender norms influenced the most the support male partners were able to give to their spouses and the support received from their social support networks. Two main needs were identified: the need to be informed and the need to know about the cost of care in health settings. The male partners revealed how the information obtained during this crucial time impacted their choices and decisions. Conclusion Male partners experiences revealed the influence of gender norms, beliefs, and social support on male partner involvement in pregnancy and childbirth. First time fathers need more information and attention and this study presents insights into what local health settings can do to ensure their informational needs are met. Keywords: male involvement, first-time fathers, pregnancy, Nigeria
Different transcriptional response between susceptible and resistant common carp (Cyprinus carpio) fish hints on the mechanism of CyHV-3 disease resistance
Authors: Tadmor-Levi Roni , Doron-Faigenboim Adi , Marcos-Haddad Jenny , Petit Jules , Hulata Gideon , Forlenza Maria , Wiegertjes Geert F. , David Lior 
Published: November 2019

Abstract
Background Infectious disease outbreaks form major setbacks to aquaculture production and to further development of this important sector. Cyprinid herpes virus-3 (CyHV-3) is a dsDNA virus widely hampering production of common carp ( Cyprinus carpio ), one of the most farmed fish species worldwide. Genetically disease resistant strains are highly sought after as a sustainable solution to this problem. To study the genetic basis and cellular pathways underlying disease resistance, RNA-Seq was used to characterize transcriptional responses of susceptible and resistant fish at day 4 after CyHV-3 infection.Results In susceptible fish, over four times more differentially expressed genes were up-regulated between day 0 and 4 compared to resistant fish. Susceptible and resistant fish responded distinctively to infection as only 55 (9%) of the up-regulated genes were shared by these fish types. Susceptible fish elicited earlier a typical anti-viral response, involving interferon and interferon responsive genes. Moreover, chemokine profiles indicated different cellular immunity responses. A comparative phylogenetic approach assisted in gene copies annotation pointing to different orthologous copies common to bony-fishes and even carp-specific paralogs that were differentially regulated and contributed to the different response of these fish types. Susceptible fish up-regulated more ccl19 chemokines, which attract T-cells and macrophages, the anti-viral role of which is established, whereas resistant fish up-regulated more cxcl8/il8 chemokines, which attract neutrophils, the antiviral role of which is unfamiliar.Conclusions Taken together, by pointing out transcriptional differences between susceptible and resistant fish in response to infection, this study unraveled possible genes and pathways that take part in disease resistance mechanisms in fish and thus, enhances our understanding of fish immunogenetics and supports the development of sustainable and safe aquaculture.
The first molecular detection of Canine herpesvirus-1 in reproductive specimens of adult dogs in Iran
Authors: Rezaei Mahdieh , Jajarmi Maziar , Alizadeh Ramin , Khalili Mohammad , Babaei Homayoon 
Published: November 2019

Abstract
Background Canine herpesvirus-1 (CHV-1) is recognized to be enzootic in the dog population with a widespread distribution. This pathogen leads to a lethal generalized illness in newborn puppies and is associated with reproductive disorders. CHV-1 should be considered as an important pathogen of neonatal death and infertility; so, it appears to pose a threat for breeding kennels. Although serologic data point to the circulation of CHV-1 among dogs of Iran, not definitive diagnosis has been conducted based on the molecular assay. So, this research was done to detect the prevalence of CHV-1 in dogs of Kerman. In this study, the presence of CHV-1 in vaginal specimens and biopsies of the uterus of dogs referring to the Veterinary Hospital of Shahid Bahonar University of Kerman was determined. Samples were collected and evaluated using real-time PCR.Results Viral DNA was detected in 21 samples from a total of 140 (15%) collected samples which were related to 14 uterine samples (20%) and 7 (10%) vaginal specimens. The association of this virus with age, breed, housing, pregnancy and reproductive disorders was not significant.Conclusions This study is the first molecular detection of CHV-1 in reproductive samples of dogs in Iran. Considering the significant prevalence of this virus, it is necessary to carry out management measures in controlling and preventing this disease. Tracing CHV-1 requires further research on this virus in dogs of this region.
Dilatation of the Cystic Duct Confluence in Laparoscopic Common Bile Duct Exploration and stone extraction for Patients with Secondary Choledocholithiasis
Authors: Yang Xiao-Bin , Xu An-Shu , Li Jian-Gang , Xu Yong-Ping , Xu De-Song , Fu Chao-Chun , Deng Da-Bo , Li Jie , Zhang Ma-Zhong 
Published: November 2019

Abstract
The advent of endoscopic and laporoscopic techniques changed surgery in many regards. A number of options exist in the management of cholelithiasis and secondary choledocholithiasis. Among them, laparoscopic common bile duct (CBD) exploration with the choledocotomy followed by laparoscopic cholecystectomy (LC) has gained popularity. However, efforts should be made for minimally invasive or non-invasive to the CBD. For this purpose, we modified the surgical modality by laparoscopic transcystic approach with dilatation of the cystic duct confluence in CBD exploration (LTD-CBDE). The aim of this work was to assess the feasibility, safety and effectivity of LTD-CBDE based on our preliminary experience.