bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modifications of abundances of some bacteria are associated with the severity of IgA nephropathy in Chinese population
Authors: Zhong ZhengXia , Tan JiaXing , Tan Li , Tang Yi , Qiu ZhiCheng , Pei GaiQin , Qin Wei 
Published: July 2020

Abstract
Background

Immunoglobulin A nephropathy (IgAN) is a common autoimmune glomerular disease, the classic manifestations of which are hematuria and proteinuria. The pathogenesis of IgAN has been associated with dysregulated intestinal mucosal immunity. However, whether gut microbial modifications play a part in IgAN remains unclear.
Methods

Blood and fecal samples were collected from 52 IgAN patients and 25 healthy controls (HCs). The gut microbiome was analyzed by 16S ribosomal RNA (rRNA) gene sequencing, followed by analyses of gut microbiota composition. Furthermore, the levels of galactose-deficient IgA1 (Gd-IgA1), soluble cluster of differentiation 14 (sCD14), lipopolysaccharide binding protein (LBP), intercellular adhesion molecule-1 (ICAM-1), and C-reactive protein (CRP) was quantified by enzyme-linked immunosorbent assay (ELISA).
Results

Substantial differences in gut microbiota were found between IgAN patients and HCs (P < 0.05). The abundance of pathogenic bacteria (Bacteroides and Escherichia-Shigella) was significantly higher in IgAN patients than in HCs, while that of beneficial strains (Bifidobacterium and Blautia spp.) was lower. Higher proportions of Escherichia-Shigella and lower proportions of Bifidobacterium spp. were observed in IgAN patients with a high urine RBC count (≥ 10/HP) and proteinuria (≥ 1 g/24 h) levers. Spearman’s correlation analysis was used to assess the association between gut microbiota and biomarkers in IgAN patients. The results showed that the genus Prevotella 7 was negatively correlated with Gd-IgA1, LBP, sCD14, and ICAM-1, while Bifidobacterium spp. presented a significant inverse relationship with LBP and Gd-IgA1. Additionally, Escherichia-Shigella was negatively correlated with Prevotella 7.
Conclusions

In IgAN patients, gut modifications were characterized by an increase in the numbers of pathogenic bacteria and a reduction in the levers of beneficial bacteria. Our results suggest that disturbance of the intestinal microflora might play a critical part in the severity of IgAN, and may be a potential therapeutic target.
Borderline Sign of A Rare Dedifferentiated Liposarcoma: Report of A Case
Authors: Wen Yang , Fang Songhua , Zhao Ming , He Xianglei 
Published: July 2020

Abstract
Background: Dedifferentiated liposarcoma (DDLPS) is a unique subtype of liposarcoma, which has obvious histological heterogeneity. Most of them manifested as the dedifferentiation of high-grade histological morphology, but a few could be the dedifferentiation of low-grade histological morphology, or present as some special types of histological or immunophenotypic characteristics. We describe, herein, a case of rare type of dedifferentiated liposarcoma, in which the dedifferentiated components are high-grade and low-grade coexisting with a relatively sharp transition.Case presentation: A 69-year-old woman with severe abdominal pain lasting for 1 hour presented to our hospital. Physical examination revealed a mobile large left abdominal mass, which was shown on abdominal CT and MRI as a huge retroperitoneal tumor with lipogenic component and solid nonlipogenic components. Tumor resection was performed. Gross examination of the resected specimen showed the gray yellow fatty mass and a round like solid nodule adjacent to the fatty mass, the cut surface of the nodule was gray-white or fish flesh color, and gray yellow in the nodular center. Microscopic examination demonstrated the tumor contains the well-differentiated liposarcoma (WDLPS) component and the DDLPS component. The latter was composed of coexisting high-grade and low-grade components in which multiple focal regions of a sudden transition between the high-grade and the low-grade dedifferentiated component were identified. Immunohistochemistry showed that P16, CDK4, and MDM2 were diffusely positive. The FISH analysis revealed the presence of MDM2 gene amplification in the nuclei of the atypical cells. A final diagnosis of DDLPS was rendered.Conclusion: In our case, the borderline sign between the high-grade and low-grade dedifferentiated components in the histology may indicate that there can be obvious differentiation lines in tumor dedifferentiation, which is classically and typically abrupt. Low-grade dedifferentiation may be a precursor lesion of high-grade dedifferentiation. MRI images cannot distinguish the two components.
Modifikasi Bentonit Menggunakan Surfaktan Kationik Benzalkonium Klorida
Authors: Turmiati Titik , Udaibah Wirda , Mulyatun Mulyatun 
Published: July 2020

<p>Bentonit alam yang telah dimodifikasi menjadi <em>organobentonit </em>dengan menggunakan surfaktakan kationik Benzalkonium Klorida sebagai agen penginterkalasi dengan berbagai variasi suhu. Material hasil sintesis diaplikasikan sebagai adsorben untuk penyerapan logam berat berupa ion logam Zn<sup>2+</sup>. Proses adsorpsi dilakukan dalam berbagai variasi kondisi yaitu pH dan waktu kontak. Hasil analisis XRD menunjukkan material bentonit yang telah dimodifikasi berhasil di sintesis, hal ini terlihat dari jarak antar lapis pada suhu 50˚C sebesar 15,06 Å, suhu 60˚C sebesar 16,76 Å dan suhu 70 ˚C sebesar 16,50 Å dibandingkan dengan bentonit alam sebesar 12,09 Å. Spektra FTIR menunjukkan serapan pita 2360 cm<sup>-1</sup> yaitu adanya vibrasi C-N dan 1465 cm<sup>-1 </sup>adanya vibrasi N-H. Hal ini menunjukkan adanya garam ammonium kuartener yang di pada <em>interlayer</em> bentonit. Penentuan pH optimum dan waktu kontak pada saat adsorpsi. Dari pH 4-8 menunjukkan bahwa pH optimum untuk proses adsorpsi ion logam Zn<sup>2+</sup> adalah pH 6 dengan daya adsorpsi sebesar 99,914%, sedangkan pada bentonit alam sebesar 92,94%, kemudian untuk waktu kontak adalah di 60-120 menit dengan daya adsorpsi sebesar 97,92% pada suhu sintesis 60˚C serta waktu kontak untuk bentonit alam 85,31%. Data kinetika adsorpsi menggunakan model <em>pseudo second order </em>lebih sesuai untuk menjelaskan proses adsorpsi ion logam Zn<sup>2+</sup>. Hal ini dapat disimpulkan bahwa bentonit yang telah dimodifikasi memiliki daya adsorpsi ion logam Zn<sup>2+</sup> yang lebih besar di bandingkan dengan bentonit yang belum termodifikasi.</p>
Locally tuned hybridized particle swarm optimization for the calibration of the nonlinear Muskingum flood routing model
Authors: Okkan Umut , Kirdemir Umut 
Published: July 2020

Abstract
In the literature about the parameter estimation of the nonlinear Muskingum (NL-MUSK) model, benchmark hydrographs have been subjected to various metaheuristics, and in these studies the minor improvements of the algorithms on objective functions are imposed as ‘state-of-the-art’. With the metaheuristics involving more control variables, the attempt to search global results in a restricted solution space is not actually practical. Although metaheuristics provide reasonable results compared with many derivative methods, they cannot guarantee the same global solution when they run under different initial conditions. In this study, one of the most practical of metaheuristics, the particle swarm optimization (PSO) algorithm, was chosen, and the aim was to develop its local search capability. In this context, the hybrid use of the PSO with the Levenberg–Marquardt (LM) algorithm was considered. It was detected that the hybrid PSO–LM gave stable global solutions as a result of each random experiment in the application for four different flood data. The PSO–LM, which stands out with its stable aspect, also achieved rapid convergence compared with the PSO and another hybrid variant called mutated PSO.
Reducing public exposure to common, harmful well water contaminants through targeted outreach to highly susceptible neighborhoods as a method of increasing the likelihood of testing and treatment of water from private wells
Authors: MacDonald Kristi , Tippett Mara 
Published: July 2020

Abstract
While the Safe Drinking Water Act mandates testing of public water supplies in the USA, private well owners are responsible for testing and treating their own water. A small percentage of well owners perform annual testing as recommended and many never test at all for common and potentially harmful groundwater contaminants. Finding effective ways to inform residents of the risks associated with their private well drinking water and promote the testing and treatment for common contaminants is a challenge faced by federal, state, and local agencies concerned with public health. Targeting residents whose wells are most at risk for having levels of regulated contaminants above the drinking water standard is a potential way to efficiently reach individuals. Results of this study show that individuals who receive specific letters that a contaminant in a neighbor's well had exceeded the maximum contaminant levels for one of five common well water contaminants (arsenic, radon, Gross Alpha, Escherichia coli, and nitrates) were more likely to test their well than were individuals who received a general letter about common contaminants in the region. Outreach that reports more localized, specific information on contaminants in well water results in an increased chance of testing when compared with more regional and generalized contaminant information.
A Comprehensive Review of Regulatory Requirements and Registration Process of Pharmaceutical Drug Products in CIS Countries
Authors: Pihwal Kapil , Pawar Neelam , Aamir Sheikh , Alam Mohammad Shahbaz , Rathee Vikas 
Published: July 2020

Background:
The CIS region has a potential market for India. The registration of the
drug products in CIS regions is a challenging task because these countries have no harmonized
regulatory organization. The CIS region includes 12 countries such as Russia, Kyrgyzstan,
Ukraine, Uzbekistan, Kazakhstan, Tajikistan, Turkmenistan, Armenia, Azerbaijan, Belarus, Georgia
and Moldova, which require different regulatory guidelines for medicinal product registration
as per their FDA guidelines. The different guidelines for the same region become a challenging
task for the manufacturer and exporter. The registration of the same product for different countries
of CIS is not possible with the same dossier due to the lack of their regulatory harmonization.
These countries obey their country-specific dossier format, so to target these market manufacturers
and exporters needs to submit different dossier documents for different countries. But Ukraine
and Kazakhstan have harmonization and it varies in Uzbekistan and Tajikistan. Ukraine and Kazakhstan
are also imposing strict rules and expecting USFDA level documents for approval.

Conclusion:
The overall conclusion is that harmonization in CIS is highly imbalanced, which affects
both time and cost for product registration. Harmonization is the need of the era for easy
product registration, and it will be beneficial for the manufacturer, regulator, importer, exporter,
and to access medicines of high public health value.
Identifikasi Praktik Kefarmasian Yang Sesuai Dengan Kebutuhan Pasien Dan Fasilitas Pelayanan Kesehatan
Authors: Siahaan Selma , Handayani Rini Sasanti 
Published: July 2020

The study of pharmaceutical practices in health care facilities was conducted in 2016. It aimed to identify pharmaceutical practices needed by patients and health care facilities. The study sites were in Central Java, Bali, South Kalimantan, and South Sulawesi. In each provinces, the study was conducted in one urban and one rural district areas. The sample locations were both government and private hospitals, health centers and pharmacies. The study design study was cross sectional. Data collection was carried out by in-depth interview to responsible pharmacists who did medicines management, and exit interview to patients after they received medicines services from government hospitals and primary health cares. The results showed that pharmaceutical practices needed by the health care facilities were good medicines planning andprocurement that can maintain the continuity of the availability of medicine stocks needed for patients, and the ability in managing medicines effi ciently and eff ectively. Moreover, the pharmaceutical practices needed by the communities were medicines completeness, quick services, as well as simple and complete medicines information. It is recommended that pharmacists should be trained on comprehensive medicines planning, strategy to anticipate the emptiness of medicines including lead times, and communication skills to the patients. In addition, IT supports for pharmacy services development is also needed.
Abstrak
Telah dilakukan studi mengenai praktik kefarmasian di fasilitas pelayanan kesehatan yang bertujuan mengidentifikasi pelayanan kefarmasian yang dibutuhkan pasien dan fasilitas pelayanan kesehatan. Kegiatan studi dilaksanakan di Jawa Tengah, Bali, Kalimantan Selatan, Sulawesi Selatan. Dari masing-masing propinsi di atas dipilih satu kota dan satu kabupaten. Studi dilakukan pada tahun 2016. Lokasi penelitian adalah rumah sakit pemerintah, rumah sakit swasta, puskesmas dan apotek dengan desain potong lintang. Pengumpulan data dilakukan melalui wawancara mendalam terhadap apoteker penanggung jawab/pengelola obat, dan exit interview terhadap pasien rumah sakit pemerintah dan puskesmas yang baru selesai menerima pelayanan obat. Hasil penelitian menunjukkan praktik kefarmasian yang dibutuhkan oleh fasilitas pelayanan kesehatan adalah perencanaan dan pengadaan obat yang baik yang dapat menjaga kesinambungan ketersediaan stok obat yang diperlukan bagi pelayanan ke pasien serta pengelolaan obat yang efektif dan efi sien. Praktikkefarmasian yang dibutuhkan masyarakat adalah tersedianya obat lengkap, kecepatan pelayanan, dan informasi obat yang singkat padat. Disarankan perlunya pelatihan perencanaan obat yang lebih komprehensif, kiat-kiat mengantisipasi kekosongan obat dan lamanya pengiriman, serta pelatihan cara berkomunikasi yang baik kepada pasien secara menyeluruh. Selain itu, dukungan teknologi informasi bagi pengembangan pelayanan farmasi juga dibutuhkan.
LAND CONVERSION AND THE LEVEL OF COMMUNITY SOCIAL COHESION IN THE SUB-DISTRICT OF EMPOANG DISTRICT BINAMU JENEPONTO REGENCY
Authors: Faisal Muhammad 
Published: July 2020

ABSTRACTThis research aims to find out land conversion that occurs and analyze relationship between the level social cohesion and collective action community after function of the land. The type research used is survey research, because takes samples from one population and uses questionnaire basic data collection tool. The number respondents was 74 people consisting 68 men and 6 women who were captured by convenience, incidental, and purfosively sampling techniques taken from those who had sold land and came from various RWs in Empoang subdisrict. Data analysis using SPSS for Windows 20 application. Test hypothesis using Rank Spearman statistical test. The results study found land conversion occurs because land is less productive and also form demographic adaptation and multi-form conversion. The results Spearman rank test obtained sig (2-tailed) value 0.013 which is smaller than alpha 0.05. This explains there is positive relationship between level social cohesion and level community involvement collective action, although the correlation coefficient is only 0.286 which explains the relationship between variables is weak. The variable level social cohesion increases, level of community involvement in collective action also increases even though the level increase is low due to the type relationship between the weak variables.
Tradisi Pabuncingan Jero Dong Ding di Desa Pakraman Muncan, Kecamatan Selat Kabupaten Karangasem
Authors: Wira Ida Ayu Dwidyaniti 
Published: July 2020

<p><em>Tradition </em><em>Pabuncingan Jero Dong Ding is one form of religious traditions god yadnya devoted presented to Ida Sang Hyang Widhi Wasa conducted with the purpose of applying the fertility presented to Ida Sang Hyang Widhi Wasa in his manifestation as Lingga (jero Dong) and Yoni (Jero Ding) ie aspect of God in the form Purusa-Pradana symbol of Lord Shiva and Goddess Parvati or Uma. Based on this analysis, be concluded as the following results: The process of implementation of the tradition Pabuncingan Jero Dong Ding in Pakraman Muncan divided into three stages: The process of making, the process Ngelinggihang and activities Pabuncingan Jero Dong Ding. The reason for the implementation of the tradition Jero Pabuncingan Ding Dong, in theology is to invoke presented to Ida Sang Hyang Widhi Wasa in manifestation of Lord Shiva and Goddess Uma, in the mythology is based on the belief or confidence that developed in rural communities Pakraman Muncan.</em><em></em></p>
Teologi Hindu dalam Teks Nīlacandra
Authors: Poniman Poniman 
Published: July 2020

<p>Memahami ajaran-ajaran teologis di Nusantara memiliki banyak sumber untuk<br />dipelajari, tetapi secara mendalam tentu membutuhkan konsentrasi yang komprehensif untuk mencari berbagai sumber ajaran demi kesempurnaan pemahaman itu. Namun dari hal itu, kehadiran suatu pengajaran tentu membutuhkan terjemahan khusus sesuai dengan bidang keilmuannya. Dalam hal ini, ini merujuk pada teks klasik yang masih menggunakan bahasa Jawa Kuno untuk menjadi objek analisis untuk menemukan perspektif spesifik tentang pengajaran teologi, yaitu Teks Nilacandra.</p>
Tattwa Siwa Siddhanta Indonesia dalam Teologi Hindu
Authors: Kardika I Nyoman 
Published: July 2020

<p>Shiva’s teachings which developed in Bali were Shiva Siddhanta, this teaching was the result of the acculturation of many teachings of Hinduism. Inside are found Vedic teachings, Upanishads, Dharmasastra, Darsana (especially Samkya Yoga), Puranas and Tantra. the concept of the teachings of Saiwa Siddhanta that lives and is embraced in Indonesia is slightly different from that developed in other countries, including different from those in India, because the concept of Saiwa Siddhanta which is embraced in Indonesia blends with the original beliefs of indigenous peopleIndonesia and local customs.therefore, Saiwa Siddhanta Indonesia cannot and cannot be equated with Saiwa Siddhanta in other parts<br />of the world. Nevertheless, Hindus do not deserve to distinguish or separate themselves between fellow believers, because Hinduism gives freedom to their people to be religious. The procedure for the implementation of religious life in Bali also shows a combination of elements of ancestral belief. Wariga, Rerainan (feast day) and Upakara are mostly ancestral heritage. this inheritance has thus been harmoniously aligned with the teachings of Hinduism so that it is a unified and rounded whole. Thus, Hinduism in Bali has a characteristic that is in accordance with the spiritual needs of Balinese people from ancient times to the present. in this day and age, the adhiluhung religion’s heritage needs to be maintained, cared for and perfected our understanding so that it can still fulfill the religious needs of its people.</p>
Nilai Teologis Arsitektur Tradisional Masyarakat Hindu di Bali
Authors: Subawa I Made Pasek 
Published: July 2020

<p>The traditional architecture of Hindu society in Bali is a blend of material and spiritual dimensions. The combination of these two dimensions form the energy and strength in the building that is created, so, it can give a sense of comfort and quiet in the person who occupy it. In the belief of Balinese, the people of Bali, the process of building construction is not just to build, but it is done by stages and careful planning, from the selection of good days, the selection of building materials, up to<br />the means of ceremony. The stage is implemented because the building is not only used as a residence, but also used as a place to carry out various ceremonial activities. This is what causes the traditional Balinese architecture has a spiritual value that makes the building has magical power that can make people who occupy it to be comfortable and quiet.</p>
Karang Paumahan Perspektif Ekologi Hindu
Authors: Harsananda Hari , Widyawati Anak Agung Ayu Alit 
Published: July 2020

<p>Human needs a good home and yard as a primary necessary. A long Ago, before human know the food producting method, human have habit to be a nomaden, haven’t home and always stay at the edge of the river, but with a good progression of our culture. Human start to stay and make a settlement. To make a good settlement Balinese people have a rule basic from a text called Asta Bhumi. From the the Asta Bhumi text can get the differentitation about the land, the good land and the bad land for make a Building. The example of the good land is the land who higher at the South and West, it called Paribhoga Werddhi and Manemu Labha, beside the rule about making ak settlement, Balinese people have a text to decreasing a bad factor from a good land. The text called Bhama Kretih, at the Bhama kretih text, find a method to solve bad land problem uses Upakara called Caru.</p>
Implementasi Strategi Pembelajaran Aktif dalam Pelajaran Agama Hindu
Authors: Junianti Putu Sri 
Published: July 2020

<p>On each there are teaching objectives to be achieved and for the achievement of these goals we need to convey topics in it there are concepts that should be up on the students, and for that particular approach is required as the solution problem solved, latiahan, trainer-memorized and possibly with other approaches. In a lesson that corresponds to a particular principle of curriculum material keterlaksanaan dipenggaruhi by four principal components, namely the carrier material, the Publisher materials, approaches and materials. In general the process of learning oriented activities on achieving a competency, hinting that Hindu religious educators should seoang mastered a number of capabilities regarding planning, how to organize and process implementation the learning itself. Active learning methods, positioning is one of the methods of positioning an educator to be able to dig into the potential that exists in his protégé so that participants can build creativity in the learning process. The application of active learning methods is an urgency that must be implemented by each school, this is because, the development of the educational world now demands the students become active and creative in the learning process.</p>
FILSAFAT PANCASILA DALAM PERSEPEKTIF HINDU
Authors: Kartika Ni Gusti Ayu 
Published: July 2020

<p>Pancasila is not just born, but through a very thorough planning process and reviewed by National figures through the session of the Preparatory Committee for the Preparation of Independence (BPPK). Pancasila as the foundation of the philosophy of the state of the Republic of Indonesia has the composition of five precepts which is a unity and unity and has the nature of the unity of the absolute, which is the nature of the monodualist nature as individual beings as well as social beings, and position as a personal being that stands alone and simultaneously also as a creature of God. The consequences of Pancasila as the basis of the state of Indonesia are all aspects in the administration of the state covered by the values of Pancasila which is the human nature that monodualis.</p>