bluuebunny/crossref_metadata_2025_split huggingface dataset:
Matching theory as enabler of efficient spectrum management in 5G networks
Authors: Tsirakis Christos , Lopez‐Aguilera Elena , Agapiou George , Varoutas Dimitris 
Published: October 2019

AbstractThis paper analyzes the spectrum trading problem in virtualized fifth generation networks to enhance the network performance with respect to the spectrum utilization. The problem is modeled as a many‐to‐many matching game with utility‐based preferences and determines the matching between mobile network operators and mobile virtual network operators. The two proposed versions of utility functions for each set aim at maximizing the satisfaction of both sets with conflicting interests and improving the overall spectrum efficiency. In the simulation evaluation, the proposed scheme is compared with three different schemes in terms of the system utility, individual, and pair matching satisfaction. We also investigate the scalability aspects, the strategy plan impact on the matching performance of our proposed scheme, and at the same time, we attempt to make appropriate assumptions closer to reality. Our proposed scheme shows much better performance than the other schemes achieving a quite high level of satisfaction for the matching result on both sets.
The anaphase‐promoting complex: A key mitotic regulator associated with somatic mutations occurring in cancer
Authors: Melloy Patricia G. 
Published: October 2019

AbstractThe anaphase‐promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that helps control chromosome separation and exit from mitosis in many different kinds of organisms, including yeast, flies, worms, and humans. This review represents a new perspective on the connection between APC/C subunit mutations and cancer. The complex nature of APC/C and limited mutation analysis of its subunits has made it difficult to determine the relationship of each subunit to cancer. In this work, cancer genomic data were examined to identify APC/C subunits with a greater than 5% alteration frequency in 11 representative cancers using the cBioPortal database. Using the Genetic Determinants of Cancer Patient Survival database, APC/C subunits were also studied and found to be significantly associated with poor patient prognosis in several cases. In comparing these two kinds of cancer genomics data to published large‐scale genomic analyses looking for cancer driver genes, ANAPC1 and ANAPC3/CDC27 stood out as being represented in all three types of analyses. Seven other subunits were found to be associated both with >5% alteration frequency in certain cancers and being associated with an effect on cancer patient prognosis. The aim of this review is to provide new approaches for investigators conducting in vivo studies of APC/C subunits and cancer progression. In turn, a better understanding of these APC/C subunits and their role in different cancers will help scientists design drugs that are more precisely targeted to certain cancers, using APC/C mutation status as a biomarker.
Serum levels of glial cell line‐derived neurotrophic factor and multiple neurotransmitters: In relation to cognitive performance in Parkinson's disease with mild cognitive impairment
Authors: Liu Yi , Tong Shuyan , Ding Li , Liu Na , Gao Dianshuai 
Published: October 2019

ObjectivesMild cognitive impairment is a common non‐motor feature of Parkinson's disease, termed PD‐MCI. But there is a scarcity of data on the role of glial cell line‐derived neurotrophic factor (GDNF) and neurotransmitters in pathogenesis of PD‐MCI. The aim of this project was to detect the serum levels of GDNF and multiple neurotranmitters and explore their relationships with cognitive performance in PD‐MCI patients.MethodsNeuropsychological testing was administered to PD patients and healthy controls to investigate different domains of cognitive function. Serum levels of GDNF and four cognition‐related neurotransmitters including Dopamine metabolites Homovanillic acid (HVA), acetylcholine (Ach), γ‐aminobutyric acid (GABA) and 5‐hydroxytryptamine (5‐HT) were detected by enzyme‐linked immunosorbent assay and liquid chromatography‐electrospray ionization tandem mass spectrometry analysis respectively.ResultsThe more serious cognitive impairment of PD, the lower levels of GDNF, HVA and 5‐HT. In PD‐MCI patients, the levels of GDNF, HVA, Ach, 5‐HT, and GABA had a significant positive correlation with Digit span backward test (DSB‐T) scores and negative correlation with the scores of Trail Making Test A (TMT‐A) and Trail Making Test B (TMT‐B) respectively. Effect size analysis showed that GDNF and GDNF*Ach have a significant effect on DSB‐T, TMT‐A and TMT‐B respectively; GDNF*HVA, GDNF*5‐HT and GDNF*GABA play important part in Auditory Verbal Learning Test separately.ConclusionsSerum GDNF may be involved in the impairment of attention, memory and executive function of PD‐MCI patients, by acting alone or in conjunction with neurotransmitters (HVA, 5‐HT, GABA, and Ach).
Passive perceptual learning modulates motor inhibitory control in superior frontal regions
Authors: Friedrich Julia , Beste Christian 
Published: October 2019

AbstractResponse inhibition is of vital importance in the context of controlling inappropriate responses. The role of perceptual processes during inhibitory control has attracted increased interest. Yet, we are far from an understanding of the mechanisms. One candidate mechanism by which perceptual processes may affect response inhibition refers to “gain control” that is closely linked to the signal‐to‐noise ratio of incoming information. A means to modulate the signal‐to‐noise ratio and gain control mechanisms is perceptual learning. In the current study, we examine the impact of perceptual learning (i.e., passive repetitive sensory stimulation) on response inhibition combining EEG signal decomposition with source localization analyses. A tactile GO/NOGO paradigm was conducted to measure action restraint as one subcomponent of response inhibition. We show that passive perceptual learning modulates response inhibition processes. In particular, perceptual learning attenuates the detrimental effect of response automation during inhibitory control. Temporally decomposed EEG data show that stimulus‐related and not response selection processes during conflict monitoring are linked to these effects. The superior and middle frontal gyrus (BA6), as well as the motor cortex (BA4), are associated with the effects of perceptual learning on response inhibition. Reliable neurophysiological effects were not evident on the basis of standard ERPs, which has important methodological implications for perceptual learning research. The results detail how lower level sensory plasticity protocols affect higher‐order cognitive control functions in frontal cortical structures.
Saturated areas through the lens: 2. Spatio‐temporal variability of streamflow generation and its relationship with surface saturation
Authors: Antonelli Marta , Glaser Barbara , Teuling Adriaan J. , Klaus Julian , Pfister Laurent 
Published: October 2019

AbstractInvestigating the spatio‐temporal variability of streamflow generation is fundamental to interpret the hydrological and biochemical functioning of catchments. In humid temperate environments, streamflow generation is often linked to the occurrence of near stream surface saturated areas, which mediate hydrological connectivity between hillslopes and streams. In this second contribution of a series of two papers, we used salt dilution gauging to investigate the spatio‐temporal variability of streamflow in different subcatchments and for different reaches in the Weierbach catchment (0.42 km2) and explored the topographical controls on streamflow variability. Moreover, we mapped stream network expansion and contraction dynamics. Finally, we combined the information on the spatio‐temporal variability of streamflow with the characterization of riparian surface saturation dynamics of seven different areas within the catchment (mapped with thermal infrared imagery, as presented in our first manuscript). We found heterogeneities in the streamflow contribution from different portions of the catchment. Although the size of the contributing area could explain differences in subcatchments' and reaches' net discharge, no clear topographic controls could be found when considering the area‐normalized discharge. This suggests that some local conditions exert control on the variability of specific discharge (e.g., local bedrock characteristics and occurrence of perennial springs). Stream network dynamics were found not to be very responsive to changes in catchment's discharge (i.e., total active stream length vs. stream outlet discharge relationship could be described through a power law function with exponent = 0.0195). On the contrary, surface saturation dynamics were found to be in agreement with the level of streamflow contribution from the correspondent reach in some of the investigated riparian areas. This study represents an example of how the combination of different techniques can be used to characterize the internal heterogeneity of the catchment and thus improve our understanding of how hydrological connectivity is established and streamflow is generated.
Application of GRACE to the estimation of groundwater storage change in a data‐poor region: A case study of Ngadda catchment in the Lake Chad Basin
Authors: Skaskevych Alla , Lee Jejung , Jung Hahn Chul , Bolten John , David John L. , Policelli Frederick S. , Goni Ibrahim B. , Favreau Guillaume , San Soma , Ichoku Charles M. 
Published: October 2019

AbstractThe present study is to explore the feasibility of GRACE‐based estimation of a groundwater storage change in a data‐poor region using a case study of the Ngadda catchment in the Lake Chad Basin. Although the Ngadda catchment has only one set of in situ time series data of groundwater from 2006 to 2009 and a limited number of groundwater measurements in 2005 and 2009, GRACE‐based groundwater storage change can be evaluated against the in situ groundwater measurements combined with specific yield data. The cross‐correlation analysis in the Ngadda catchment shows that maximum rainfall reached in July and August, whereas both the maximum total water storage anomaly and the maximum groundwater storage anomaly occurred 2months later. Whereas the mean annual amplitude of total water storage anomaly is about 17cm from both the average total water storage anomaly from three mascon products and the one from three spherical harmonic products, the mean annual amplitude of soil moisture storage anomaly is substantially varied from 5.58cm for CLM to about 14cm for NOAH and Mosaic. The goodness‐of‐fit tests show that CLM soil moisture produces the closest estimation of groundwater storage anomaly to the in situ groundwater measurements. The present study shows that GRACE‐based estimation for groundwater storage anomaly can be a cost‐effective and alternative tool to observe how groundwater changes in a basin scale under the limitation of modelling and in situ data availability.
Hepatitis B surface antigen reduction as a result of switching from long‐term entecavir administration to tenofovir
Authors: Tamaki Nobuharu , Kurosaki Masayuki , Kirino Sakura , Yamashita Koji , Osawa Leona , Sekiguchi Shuhei , Hayakawa Yuka , Wang Wan , Okada Mao , Higuchi Mayu , Takaura Kenta , Maeyashiki Chiaki , Kaneko Shun , Yasui Yutaka , Tsuchiya Kaoru , Nakanishi Hiroyuki , Itakura Jun , Takahashi Yuka , Enomoto Nobuyuki , Izumi Namiki 
Published: October 2019

Background and AimLoss of hepatitis B surface antigen (HBsAg) is an important goal in the treatment of chronic hepatitis B. We investigated whether switching from long‐term entecavir (ETV) administration to tenofovir (TFV) (tenofovir alafenamide [TAF] or tenofovir disoproxil fumarate [TDF]) could contribute to the reduction of HBsAg levels.MethodsThe degree of HBsAg reduction by 48 weeks in 30 patients following switching from ETV to TFV was compared with results from 147 patients who continued ETV as a control.ResultsTFV group switched to TFV after mean 6.79 years of ETV administration. HBV‐DNA levels remained below 1.0 log IU/mL in all cases in both groups during 48 weeks. Median HBsAg reduction at 48 weeks was 0.075 (−0.05 to 0.38) log/IU/mL in the TFV switch group, and 0.070 (−0.28 to 0.50) in the ETV continuation group, which was not statistically significant (p = 0.5). In a subgroup of hepatitis B e antigen negative patients whose HBsAg had not been reduced (HBsAg reduction ≤0 log IU/mL) in the 48 weeks prior to entry into the study, HBsAg reduction was significantly higher in the TFV switch group than in the ETV continuation group (0.15 [0.07–0.135] in TFV, 0.09 [−0.14 to 0.25] log IU/mL in ETV, p = 0.04).ConclusionAlthough HBsAg reduction is equivalent with ETV continuation and switching to TFV in all patients at 48 weeks, switching from ETV to TFV could provide an alternative therapeutic strategy toward HBsAg elimination in a specific subpopulation of patients.
Interactions between an amphipathic di‐histidine peptide and a metal affinity chromatographic resin derived from a bis(tacn)butane chelating ligand
Authors: Kreher Ute , Spiccia Leone , Hearn Milton T. W. 
Published: October 2019

AbstractThe interactive behavior of an amphipathic peptide with the Cu2+, Ni2+, and Zn2+ complexes of 1,4‐bis(triazacyclonon‐1‐yl)butane), bis(tacn)but, immobilized onto Sepharose CL‐4B, has been investigated. The effects of incubation time, as well as the incubation buffer pH and ionic strength, have been examined. The binding data have been interrogated using Langmuir, Langmuir‐Freundlich, bi‐Langmuir, and Temkin isothermal models and Scatchard plots. These results confirm that this amphipathic peptide binds with relatively high capacities to the immobilized Cu2+‐ and Ni2+‐1,4‐bis(triazacyclonon‐1‐yl)butane)‐Sepharose CL‐4B sorbents via at least two discrete sites. However, the corresponding immobilized Zn2+‐sorbent had low binding capacity. Moreover, the magnitude of the binding capacities of these sorbents was dependent on the pH and ionic strength of the incubation buffer. These results are relevant to the isolation of E. coli expressed recombinant proteins that incorporate this and related amphipathic peptide tags, containing two or more histidine residues, located at the N‐ or C‐terminus of the recombinant protein, and the co‐purification of low abundance host cell proteins of diverse structure, by immobilized metal ion affinity chromatographic methods.
Typologies of Combat Exposure and Their Effects on Posttraumatic Stress Disorder and Depression Symptoms
Authors: Kelber Marija Spanovic , Smolenski Derek J. , Workman Don E. , Morgan Maria A. , Garvey Wilson Abigail L. , Campbell Marjorie S. , Evatt Daniel P. , Belsher Bradley E. 
Published: October 2019

AbstractThe present study identified distinct classes of U.S. military service members based on their combat experiences and examined mental health outcomes and longitudinal growth curves of posttraumatic stress disorder (PTSD) and depression symptoms associated with each class. Participants were 551 active duty service members who screened positive for PTSD and/or depression based on DSM‐IV‐TR criteria. All participants completed the Combat Experiences Scale at baseline as well as PTSD and depression measures at baseline and at 3‐, 6‐, and 12‐month follow‐ups. A latent class analysis identified four classes of service members based on their combat experiences: limited exposure, medical exposure, unit exposure, and personal exposure. Service members in the personal exposure class were characterized by a distinct mental health profile: They reported a higher level of PTSD symptoms at baseline and a higher prevalence of traumatic brain injury and PTSD diagnoses during the course of the study. The limited exposure class was more likely to receive diagnoses of depression and adjustment disorders. All classes except the medical exposure class demonstrated a slight decrease in PTSD and depression symptoms over time. However, participants in the limited exposure class had a larger decrease in PTSD and depression symptoms earlier in care but did not demonstrate superior long‐term symptom improvements at 12 months compared to the other groups. These results inform PTSD development models and have implications for the screening and clinical management of combat‐exposed service members.
Condition Bias of Decoy‐Harvested Light Geese During the Conservation Order
Authors: Fowler Drew N. , Webb Elisabeth B. , Vrtiska Mark P. 
Published: October 2019

ABSTRACTEvidence that decoy harvest techniques primarily remove individuals of poorer body condition is well established in short‐lived duck species; however, there is limited support for condition bias in longer‐lived waterfowl species, such as geese, where decoy harvest is considered primarily additive because of their high natural survival rates. We evaluated support for the harvest condition bias hypothesis of 2 long‐lived waterfowl species, the lesser snow goose (Anser caerulescens caerulescens) and Ross's goose (Anser rossii). We used proximate analysis to quantify lipid and protein content of lesser snow and Ross's geese collected during the Light Goose Conservation Order (LGCO) in 2015 and 2016 during spring migration in Arkansas, Missouri, Nebraska, and South Dakota, USA. In each state, LGCO participants collected birds using traditional decoy techniques and we collected birds from the general population using jump‐shooting tactics. Total body lipid content in both lesser snow and Ross's geese varied with age, region of harvest, and harvest type (decoy or jump‐shooting). On average, adult lesser snow and Ross's geese harvested over decoys had 60 g and 41 g, respectively, fewer lipids than conspecifics collected using jump‐shooting. We observed lower lipid reserves in decoy‐shot geese in all 4 states sampled despite general gains in lipid reserves as migration chronology progressed. Our data support that the harvest condition bias extends to longer‐lived waterfowl species and during a life‐history event (spring migration) in which harvest is not normally observed. In the case of overabundant light geese, the disproportionate harvest of poorer‐conditioned lesser snow and Ross's geese may serve as an additional challenge against any realized effects of harvest to reduce the population, in addition to extremely low harvest rates. © 2019 The Wildlife Society.
How to Fight Kinetics in Complex Radical Polymerization Processes: Theoretical Case Study of Poly(divinyl ether‐alt‐maleic anhydride)
Authors: Bolshchikov Boris D. , Tsvetkov Vladimir B. , Alikhanova Olga L. , Serbin Alexander V. 
Published: October 2019

AbstractProducts of free‐radical polymerization (FRP) are usually not regulated on the molecular scale, consisting of blocks obtained through the fastest kinetic scheme pathways. The side or kinetically restricted products can be a source of impurities in a complex FRP case, or possess new properties if isolated solely. FRP synthesis of poly(divinyl ether‐alt‐maleic anhydride), known as “DIVEMA”, serves as a polymerization example with such kinetic and thermodynamic complexities. Uncertainty in factors regulating polymer structure is a challenge in advancement “DIVEMA” derivatives toward medical practice. In‐depth investigation via quantum‐chemical and molecular mechanics methods unveils mechanistic aspects of polymer stereoisomerism and confirms possible isolation of thermodynamically or kinetically controlled products on a large data set. Strategies toward regulation of 5‐exo/6‐endo cycloisomerism are theorized and then studied via microkinetic modeling. Thermodynamically controlled products can be isolated utilizing lower monomer concentrations, in range of 10−3 to 10−1 m, and/or application of a complexing agent that is better to realize via solvents, capable of formation π‐ and σ‐radical complexes. Change of electrophilic monomer is proposed as an approach for designing more molecularscale adjustable copolymerization processes. Methodology, obtained results, and conclusions for “DIVEMA” can be valuable to control other FRP processes on the molecular scale, unlocking polymers with improved or new functionalities.
Enhanced mechanical and thermal properties of polyurethane‐imide foams with the addition of expended vermiculite
Authors: Xiong Weiwen , Wu Jiali , Tian Huafeng , Xiang Aimin , Wang Chaoyang , Wu Qiangxian 
Published: October 2019

AbstractPolyurethane‐imide (PUI) foams, in combination with the mechanical performance of polyurethane and flame retardancy of polyimide, were prepared by polyimide prepolymer method. Expended vermiculite (EV), with a wider layer spacing than vermiculite, was used as the filler to further enhance the mechanical and thermal properties of the PUI foams. The effect of filler content on the morphology of foams was also investigated. The results showed that the mean cell diameter of foams became smaller and the cell size distribution was more uniform at low filler content. The addition of EV resulted in a substantial increase in thermal stability. The compression strength increased from 0.024 to 0.065 MPa with an increase in EV content from 0% to 9.6%. The limited oxygen index values increased from 24% to 30.8% with an increase in filler content from 0% to 9.6%. Hence, PUI foams could significantly enlarge its application range with the addition of EV.
Improving fetal congenital heart disease screening using a checklist‐based approach
Authors: Janicki Mary B. , Fernandez Christopher G. , Wakefield Dorothy , Shepherd Jonathan P. , Figueroa Reinaldo 
Published: October 2019

AbstractTo determine if using a checklist of specific ultrasound image criteria to screen the fetal heart improves the cardiac exam completion rate, defined as the ability to classify the heart as normal or abnormal. This is a retrospective cohort study of patients with singleton pregnancies who underwent a fetal anatomy survey between 18 and 28 weeks' gestation. A checklist was used from 1 September 2015 to 31 March 2016 to categorize exams as complete‐normal, complete‐abnormal, or incomplete. Performance was compared with a 7‐month period prior to checklist introduction (1 December 2014 to 30 June 2015). Checklist utilization improved the cardiac exam completion rate by 8.9%. With the checklist, 1083 of 1202 exams (90.1%) were completed compared to 987 of 1193 (82.7%) pre‐checklist, P < .001. We did not detect a change in cases classified as abnormal and referred for echocardiography: 25 (2.1%) with the checklist and 16 (1.3%) pre‐checklist, P = .16. We did not detect more congenital heart disease (CHD), 12 (1.0%) with checklist screening, 5 (0.4%) pre‐checklist, P = .14. Critical CHD was not missed in either group. Using the checklist improved the cardiac exam completion rate. There was no change in congenital heart disease detection.