bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Postprandial Very-low-density Lipoprotein in the Development of Atrial Remodeling in Metabolic Syndrome
Authors: Lee Hsiang-Chun , Shin Shyi-Jang , Huang Jih-Kai , Lin Yu-Hsun , Ke Liang-Yin , Jiang He-Jiun , Tsai Wei-Chung , Chao Min-Fang , Lin Yi-Hsiung 
Published: June 2020

Abstract
Background:Negatively charged very-low-density lipoprotein (VLDL-χ) in metabolic syndrome (MetS) patients exerts cytotoxic effects on endothelial cells and atrial myocytes. Atrial cardiomyopathy, manifested by atrial remodeling with a dilated diameter, contributes to atrial fibrillation pathogenesis and predicts atrial fibrillation development. The correlation of VLDL-χ with atrial remodeling is unknown. This study investigated the association between VLDL-χ and left atrial dilatation. Methods: We evaluated 87 MetS and 80 non-MetS individuals between 23 and 74 years old (50.6% men) without overt cardiovascular diseases. Blood samples were collected while fasting and postprandially (at 0.5, 1, 2, and 4 hours after a unified meal). VLDL was isolated by ultracentrifugation; the percentile concentration of VLDL-χ (%) was determined by ultra-performance liquid chromatography. The correlations of left atrial diameter (LAD) with variables including VLDL-χ, LDL-C, HDL-C, triglycerides, glucose, and blood pressure, were analyzed by multiple linear regression models. A hierarchical linear model was conducted to test the independencies of each variable’s correlation with LAD. Results: The mean LAD was 3.4 ± 0.5 cm in non-MetS subjects and 3.9 ± 0.5 cm in MetS patients (P< 0.01). None of the fasting lipid profiles were associated with LAD. VLDL-χ, BMI, waist circumference, hip circumference, and blood pressure were positively correlated with LAD (all P<0.05) after adjustment for age and sex. We observedsignificant interactions between VLDL-χ and blood pressure, waist circumference, and hip circumference. When adjusted for obesity- and blood pressure-related variables, 2-hour postprandial VLDL-χ (mean 1.30 ± 0.61%) showed a positive correlation with LAD in MetS patients. Each 1% VLDL-χ increase was estimated to increase LAD by 0.62 cm. Conclusions: Postprandial VLDL-χ is associated with atrial remodeling. VLDL-χ is a novel biomarker for atrial cardiomyopathy in MetS patients and may be a therapeutic target. Trial registration: ISRCTN 69295295. Retrospectively registered 9 June 2020.
Scour depth in confluences considering tributary flow, bank slope, and post-confluence conditions
Authors: Khosravinia Payam , Malekpour Amir , Nikpour Mohammad Reza , Hosseinzadeh Dalir Ali 
Published: June 2020

Abstract
In this paper, scouring in confluences was experimentally studied considering the effects of bank slope angle (θ) of the main channel, discharge ratio (Qr) of tributary channel and densimetric Froude number (Frg3) of the post-confluence channel. The experiments were conducted using a constant confluence angle (α) equal to 90° and various bank slope angles of 45°, 60°, 75° and 90°. Applying different Qr and Frg3, the maximum effect of θ on scour depth was observed when the minor Qr was used in the tributary channel. The mildest bank slope angle caused the minimum scour depth for any given Frg3. Generally, the experiment using θ = 45° and Qr = 0.194 showed the best performance and reduced the maximum scour depth by 46%. Considering two obtained empirical relationships, it was concluded that the effect of θ on the height of the point bar is more than its effect on the scour depth. Finally, Frg3 and θ demonstrated their greatest influences on dimensionless scour depth (dse/y3) and dimensionless height of point bar (Hse/B3), respectively.
Extracts of Leaves of Six Locally Available Plants from Bagmati Province of Nepal as Potent Inhibitors of Alpha-amylase, Lipase, Tyrosinase, Elastase, and Cholinesterases
Authors: Pandey Bishnu P. , Pradhan Suman P. , Adhikari Kapil , Joshi Prayon , Malla Sudeshna 
Published: June 2020

Background:
Medicinal plants and their products are gaining global popularity due to
their several health benefits. However, the biological activities of the vast majority of medicinal plant
species have not been explored yet. In this study, we evaluated the enzyme inhibitory potential of six
medicinal plant species involved in digestion, skin-related problems, and neurological problems.

Methods:
The 80% methanol extracts of leaves of six locally available plants from the Bagmati province
of Nepal were analyzed for their flavonoids content, phenolics content, antioxidant activity, and
enzymes inhibitory potential. Antioxidant activity was analyzed by the DPPH assay. Alpha-amylase
inhibition was carried out by the DNSA method. Lipase, tyrosinase, elastase, acetylcholinesterase,
and butyrylcholinesterase inhibitions were analyzed by using p-NPB, L-DOPA, AAAPVN,
acetylthiocholine, and butyrylthiocholine as a respective substrate.

Results:
Among the analyzed plants species, Artocarpus heterophyllus displayed highest α-amylase
(IC50=6.28 ± 0.01 μg/mL), lipase (IC50= 475.14 ± 3.17 μg/mL), elastase (IC50= 72.75 ± 3.41 μg/mL)
and acetylcholinesterase (IC50= 68.66 ± 1.71 μg/mL) inhibition, whereas, Actinidia deliciosa displayed
highest tyrosinase inhibition (IC50=139.87 ± 0.72 μg/mL) and butyrylcholinesterase inhibition
(IC50= 18.32 ± 0.44 μg/mL). Furthermore, Jasminum humile showed no inhibitory tendencies against
elastase and Lygodium japonicum showed no inhibition towards lipase and elastase at the given concentration
range.

Conclusions:
Our study revealed that A. deliciosa and A. heterophyllus are the potential source of α-
amylase, lipase, elastase, acetylcholinesterase, and butyrylcholinesterase inhibitors. Based on our
findings, we concluded that the analyzed plant species are of great scientific interest to the pharmaceutical,
cosmetics, and food industries.
Remifentanil with or without Propofol as Anesthesia Agents for Trans-Vaginal Ultrasonography Oocyte Retrieval (TUGOR) on Pregnancy and Anesthesia Outcomes: A Randomized Controlled Trial
Authors: Atashkhoei Simin , Pouya Khadijeh , Hakimi Parvin , Zakeri Raana , Soltanzadeh Nasrin , Hatami-Marandi Pouya 
Published: June 2020

Background:
Transvaginal Ultrasound-Guided Oocyte Retrieval (TUGOR) is a painful
procedure, which often requires the application of anesthesia agents. There is a controversy in the
literature about the effects of administrated anesthetics for TUGOR on patients & pregnancy outcomes.

Objective:
The current study aimed to compare the effects of remifentanil with or without propofol,
administrated for TUGOR, on pregnancy and anesthesia outcomes.

Method:
In a double-blind randomized controlled trial, 180 candidates of TUGOR, aged 18-40
years old, were included in the study. All study women received midazolam 0.03 mg/kg and
remifentanil 1 ug/kg as anesthesia induction; Later on, they were randomly assigned in two equalsize
groups in terms of anesthesia maintenance, as the intervention group received remifentanil
infusion 0.25 μg/kg/min and the control group received remifentanil infusion 1ug/kg/min with propofol
50-150 ug/kg/min. Hemodynamic symptoms, operation outcomes, including the side effects,
and pregnancy outcomes, were compared between the study groups. The study is registered with the
Iranian Clinical Trials Registry, number IRCT201611177013N15.

Results:
Although the hemodynamic symptoms showed significantly better ranges in the remifentanil
group, however, the study groups were not significantly different in durations of operation,
anesthesia, and recovery. However, the anesthesia side effects during and after the operation were
not significantly different between the groups; they were more common in control one. The reproductive
outcomes (numbers of collected oocytes, fertilized oocytes and transferred embryos, pregnancy
rates) showed better but non-significant ranges in the remifentanil group.

Conclusion:
Using remifentanil alone in comparison to remifentanil & propofol in the TUGOR
procedure can be achieved better pregnancy outcomes without imposing the side effects of propofol;
therefore, it is not recommended to use propofol as an anesthesia agent for a TUGOR procedure.
A Review on the Use of Reversal Agents of Direct Oral Anticogulant Drugs in Case of Gastrointestinal Bleeding
Authors: Ojetti Veronica , Saviano Angela , Brigida Mattia , Saviano Luisa , Migneco Alessio , Franceschi Francesco 
Published: June 2020

Background:
Major bleeding is a life-threatening condition and a medical emergency
with high mortality risk. It is often the complication of anticoagulant’s intake. Anticoagulants are
commonly used for the prevention and treatment of thrombotic events. The standard therapy with
vitamin K antagonist (warfarin) has been frequently replaced by direct oral anticoagulants (DOACs).
The latter agents (rivaroxaban, apixaban, edoxaban, dabigatran, and betrixaban) showed better
efficacy and safety compared to standard warfarin treatment and they are recommended for the reduction
of ischemic stroke. Literature data reported a high risk of gastrointestinal bleeding with
DOACs, in particular with dabigatran and rivaroxaban. In case of life-threatening gastrointestinal
bleeding, these patients could benefit from the use of reversal agents.

Methods:
We performed an electronic search on PUBMED of the literature concerning reversal
agents for DOACs and gastrointestinal bleeding in the Emergency Department from 2004 to 2020.

Aim:
This review summarizes the current evidence about three reversal agents idarucizumab, andexanet
alfa and ciraparantag, and the use of the first two in the emergency setting in patients with
active major bleeding or who need urgent surgery which physicians indicate for a better management
approach in order to increase patient’s safety.

Conclusion:
Although these agents have been marketed for five years (idarucizumab) and two
years (andexanet alfa) respectively, and despite guidelines considering antidotes as first-line agents
in treating life-threatening hemorrhage when available, these antidotes seem to gain access very
slowly in the clinical practice. Cost, logistical aspects and need for plasma level determination of
DOAC for an accurate therapeutic use probably have an impact on this phenomenon.. An expert
multidisciplinary bleeding team should be established so as to implement international guidelines
based on local resources and organization.
Management of Pleural Effusions in the Emergency Department
Authors: Congedo Maria Teresa , Ferretti Gian Maria , Nachira Dania , Pennisi Mariano Alberto 
Published: June 2020

Background:In symptomatic patients, admitted in emergency department for acute chest pain and dyspnea, who require an urgent treatment, a rapid diagnosis and prompt management of massive pleural effusion or hemothorax can be lifesaving.Aims:The aim of this review was to summarize the current diagnostic and therapeutic approaches for the management of the main types of pleural effusions that physicians can have in an emergency department setting.Methods:Current literature about the topic was reviewed and critically reported, adding the experience of the authors in the management of pleural effusions in emergency settings.Results:The paper analyzed the main types of pleural effusions that physicians can have to treat. It illustrated the diagnostic steps by the principal radiological instruments, with a particular emphasis to the role of ultrasonography, in facilitating diagnosis and guiding invasive procedures. Then, the principal procedures, like thoracentesis and insertion of small and large bore chest drains, are indicated and illustrated according to the characteristics and the amount of the effusion and patient clinical conditions.Conclusion:The emergency physician must have a systematic approach that allows rapid recognition, clinical cause identification and definitive management of potential urgent pleural effusions.
Multi-label Learning for the Diagnosis of Cancer and Identification of Novel Biomarkers with High-throughput Omics
Authors: Liu Shicai , Tang Hailin , Liu Hongde , Wang Jinke 
Published: June 2020

Background:
The advancement of bioinformatics and machine learning has facilitated the
diagnosis of cancer and the discovery of omics-based biomarkers.

Objective:
Our study employed a novel data-driven approach to classifying the normal samples and
different types of gastrointestinal cancer samples, to find potential biomarkers for effective diagnosis
and prognosis assessment of gastrointestinal cancer patients.

Methods:
Different feature selection methods were used, and the diagnostic performance of the proposed
biosignatures was benchmarked using support vector machine (SVM) and random forest (RF)
models.

Results:
All models showed satisfactory performance in which Multilabel-RF appeared to be the best.
The accuracy of the Multilabel-RF based model was 83.12%, with precision, recall, F1, and Hamming-
Loss of 79.70%, 68.31%, 0.7357 and 0.1688, respectively. Moreover, proposed biomarker signatures
were highly associated with multifaceted hallmarks in cancer. Functional enrichment analysis and impact
of the biomarker candidates in the prognosis of the patients were also examined.

Conclusion:
We successfully introduced a solid workflow based on multi-label learning with High-
Throughput Omics for diagnosis of cancer and identification of novel biomarkers. Novel transcriptome
biosignatures that may improve the diagnostic accuracy in gastrointestinal cancer are introduced for
further validations in various clinical settings.
Competitive Biosorption of Pb(II) and Cu(II) by Functionalised Micropogonias undulates Scales
Authors: Ighalo Joshua O. , Tijani Ibrahim O. , Ajala Oluwaseun J. , Ayandele Fisayo O. , Eletta Omodele A.A. , Adeniyi Adewale G. 
Published: June 2020

Background:
Modified bio-based adsorbents from plant sources can be used for
pollution remediation by adsorption due to their low cost and availability in large quantities.

Objective:
In this study, the competitive biosorption of Pb(II) and Cu(II) by Micropogonias
undulates functionalised fish scales (FFS) was conducted. The functionalisation was done by
wet impregnation with Fe2+.

Method:
The biosorbent was characterised by Fourier Transform Infrared Spectroscopy
(FT-IR), Scanning Electron Microscopy with Energy-Dispersive X-ray Spectroscopy (SEMEDS)
and Branueur-Emmett-Teller (BET) analyses.

Results:
The major constituents in the FFS were calcium and phosphorus from the collagen
and apatite on the scales. Optimum removal efficiency for both metals was >99% at 10 g/l
dosage. It was observed that the Langmuir isotherm model and the pseudo second order kinetics
model were the best fit for the experimental data. The monolayer adsorption capacity
of FFS for Pb(II) and Cu(II) was observed to be 96.15 mg/g and 100 mg/g, respectively.

Conclusion:
The study revealed that the competitive biosorption of heavy metals can be
achieved (at a good adsorption capacity) using functionalised Micropogonias undulates fish
scales.
Peran pendidikan kearsipan dalam menghidupkan arsip dan kehidupan sosial
Authors: Bramantya Arif Rahman 
Published: June 2020

Introduction. The establishment of archival science study programs at the undergraduate (including archival applied) level leads to efforts to develop archival education and fulfillment of the needs of professional archivists. This paper discusses the importance of established and strong archival education by implementing more effective competency standards.
Data Collection Method. The method used in this research was literature study with qualitative approach.
Data Analysis. The data was analyzed by using a descriptive-analytic approach.
Results and Discussion. The establishment of the archiavl study programs will have great impacts on the quality of the graduates. The establishment also affected the scientific development of archival science, with the fact that the number of archival science study programs is limited. The non-standard curriculum by each study program also needs to be further professionally discussed.
Conclusion. Competency standards in professional archivist development must ensure the clear objectives and tailored competency to support the archival science. Finally, archival education is to form humans’ characteristics to solve social problems in society, particularly the field of archival education.
Perkembangan publikasi internasional bidang pemantauan radiasi tahun 2011-2019 melalui basisdata Scopus
Authors: Noeraida Noeraida 
Published: June 2020

Introduction. Researchers and engineers at the National Nuclear Energy Agency need data to map research progress in the field of radiation monitoring. The purpose of the study was to find out the development of productive publications, researchers, institutions, countries, and journals that were widely cited, knowledge mapping, researcher collaboration, and Indonesian researcher publications in the field of radiation monitoring.
Data collection method. Using the bibliometric analysis method, with a quantitative approach, population data from Scopus in 2011-2019, and mapping visualized using VOSviewer.
Analysis Data. Analysis of the data used is evaluative descriptive.
Results and discussions. The results of the study found the growth of publications increased by an average of 274 titles per year, comparison of publications with citing articles was 1: 3. Productive researcher, widely cited and popular Onda Y. from the University of Tsukuba, Japan, the productive institutions of the Japan Atomic Energy Agency, Japan and the most cited are the University of Tsukuba, Japan; productive and many countries become Japan's reference. The journal that mostly publishes research in the field of radiation citation monitoring is the Journal of Environmental Radioactivity, a document that is widely cited is written by Halliburton of Cleveland State University USA. Key knowledge mapping related to radiation monitoring are reactor accidents and nuclear power plants. Researchers in the field of radiation monitoring in Indonesia are inadequate, 50% are written by BATAN researchers, others collaborate with institutions from within and outside the country.
Conclusions. Based on the results of the study shows Japan dominates as a country that has the most developing, productive and popular publications for researchers, institutions and countries as well as being a reference for other researchers in the world. The accident at Fukushima was a good experience, evaluation, knowledge and research for Japan.
Implementasi Personal Assistant Library Service (PALS) dalam meningkatkan layanan referensi di perpustakaan perguruan tinggi
Authors: Febriyanto Febriyanto , Tamara Adriani Salim  
Published: June 2020

Introduction. The academic library in the Pancoran area have user-oriented reference services by creating services called Personal Assistant Library Service (PALS). This paper discusses the reference services at Pancoran University which aims to describe the implementation of PALS at Universitas Pancoran as an effort to improve the academic library.
Method. The method uses case study with qualitative approach. Techniques of collecting data through interviews conducted on librarians who work in the library.
Results and Discussions. The findings of the strategy undertaken in an effort to improve reference services at the Pancoran University library can be done in a personal way by forming PALS services. In the case of Pancoran University, these efforts are reflected in the collection support provided for new services, reassessing the competencies needed for services and seeing the challenges that exist in its implementation.
Conclusion. The improvement of college library services through PALS is an alternative that can be used by other university libraries even though the application at Pancoran University has not been maximized. PALS focuses on the needs of college library users with high ability needs and different subjects with personal handling.
Larry V. Larrichio. La construcción multicultural de una economía colonial: Cambio demográfico y organización del trabajo en el Valle medio del Cauca siglo XVIII. Pereira: Editorial Universidad Tecnológica de Pereira, 2018
Authors: López García Edwin Mauricio 
Published: June 2020

El trabajo del profesor Larry Larrichio se constituye en una ventana que permite explorar un periodo histórico de la colonia, que a nivel regional no ha sido revisado a mayor profundidad, pues los historiadores profesionales o académicos del Centro Occidente Colombiano, han tenido en la mira otras etapas históricas, que mayoritariamente se han decantado por estudiar el origen del proceso de subyugación y dominio de los españoles sobre los grupos indígenas conocido como “La Conquista” y, el proceso de poblamiento y fundación de localidades ocurrido desde inicios del siglo XIX hasta principios del XX, el cual se ha denominado como “Colonización Antioqueña”. De esta forma, esta obra entrelaza y sirve como puente entre la conquista española y la colonización antioqueña, puntos focales que dentro de la historiografía regional han sido los dos procesos sociales del pasado, sobre los cuales se ha construido una visión histórica regional que revela la preocupación por entender dos momentos originarios y fundacionales del Centro Occidente colombiano, pero que se ha desentendido por obtener una comprensión diacrónica del pasado.
Ricardo D. Salvatore, Paisanos itinerantes. Orden estatal y experiencia subalterna en Buenos Aires durante la era de Rosas. Ciudad Autónoma de Buenos Aires, Prometeo, 2018, Historia Argentina, 538 páginas
Authors: Pose Lucía 
Published: June 2020

Revisión del libro Paisanos itinerantes. Orden estatal y experiencia subalterna en Buenos Aires durante la era de Rosas por Ricardo D. Salvatore
Marcelino Viera, Modernidad sublimada. Escritura y política en el Río de la Plata. Madrid-Frankfurt, Iberoamericana-Vervuert, 2019, Nexos y Diferencias. Estudios de la Cultura de América Latina, 352 páginas
Authors: Venturini Corbellini Joaquin 
Published: June 2020

Revisión del libro Modernidad sublimada. Escritura y política en el Río de la Plata por Marcelino Viera
reforma laboral española según los diarios argentinos
Authors: Coscia Vanesa , Russo Raffaele 
Published: June 2020

En este artículo se analiza cómo los principales diarios de Argentina (Clarín y La Nación) representaron la reforma laboral española de 2012 y, en particular, las nociones de flexibilización y precarización laboral. En el contexto global actual, donde se han sancionado recientemente reformas laborales o se debaten nuevos cambios: Italia y Francia en Europa; México, Brasil y Argentina en América Latina, resulta interesante analizar, a la luz del caso español, cuáles son los énfasis noticiosos y sentidos privilegiados por los grandes medios, respecto del trabajo, los sindicatos y los derechos laborales.
Dampak penghasilan istri pada kepuasan pernikahan dewasa
Authors: Rumondor Pingkan C. B. , Paramita Greta Vidya , Francis Nangoi Priscilla , Geni Putri Lenggo 
Published: June 2020

Penelitian ini ditujukan untuk melihat dampak dari penghasilan istri terhadap kepuasan pernikahan. Kepuasan pernikahan dideinisikan sebagai pengalaman subjektif individu terhadap pernikahan dan komponen-komponen dalam pernikahan. Pengukuran kepuasan pernikahan menggunakan skala Kepuasan Pernikahan Pasangan Urban yang dikonstruk oleh peneliti. Bentuk akhir dari skala ini terdiri dari 38 butir soal yang mengukur kepuasan individu dalam dimensi komunikasi, keseimbangan pembagian peran, kesepakatan, keterbukaan, keintiman, keintiman sosial dalam relasi, seksualitas, inansial, dan spiritualitas. Hasil analisis menunjukkan bahwa alat ukur ini reliabel (?= 0.967) dan memiliki korelasi dengan penilaian subjektif mengenai kepuasan pernikahan secara keseluruhan (r = 0.293, p < 0.05). Hasil penelitian ini didapatkan bahwa tidak terdapat perbedaan kepuasan pernikahan dewasa muda bila ditinjau dari tingkat penghasilan istri (p > 0.05).