bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preprocedural computed tomography before cardiac implanted electronic device lead extraction: Indication, technique, and approach to interpretation
Authors: Lewis Robert K. , Ehieli Wendy L. , Hegland Donald D. , Pokorney Sean D. , Chalian Hamid , Iranmanesh Reggy , Hurwitz Koweek Lynne M. , Piccini Jonathan P. 
Published: January 2020

AbstractCardiac implantable electronic devices (CIEDs) frequently need to be extracted due to infection, hardware failure, and other causes. The extraction of the CIED is typically performed using percutaneous methods. While these procedures are mostly performed without incident there is a small risk of significant complications. Dedicated imaging pre‐CEID removal to include the central veins and heart with multidetector computed tomography (MDCT) can be utilized to evaluate the lead course and termination, the integrity of the central veins and cardiac chambers, and identify potential complications that may alter the lead extraction procedure as well as reimplantation of subsequent leads. Indications for preprocedural imaging, the technique of dedicated preprocedural lead extraction MDCT, and the approach to the interpretation of the images is discussed in this review.
Role of inducibility and its dynamic change in the outcome of catheter ablation of atrial fibrillation: a single center prospective study
Authors: Darma Angeliki , Daneschnejad Sait S. , Gaspar Thomas , Huo Yan , Wetzel Ulrike , Dagres Nikolaos , Husser Daniela , Sommer Philipp , Piorkowski Christopher , Bollmann Andreas , Hindricks Gerhard , Arya Arash 
Published: January 2020

AbstractBackgroundThe role of atrial arrhythmia inducibility as an endpoint of catheter ablation of atrial fibrillation (AF) has been a controversial subject in many studies. Our goal is to evaluate the significance of inducibility, the impact of multiple sites or protocols of stimulation or the change in inducibility status in a prospective study including patients with AF undergoing first catheter ablation.MethodsWe studied 170 consecutive patients with AF (62.9% paroxysmal) undergoing catheter ablation. All patients underwent two separate stimulation protocols before and after the ablation from the coronary sinus ostium and the left atrial appendage: burst pacing at 300, 250, 200 milliseconds (or until refractoriness) for 10 seconds and ramp decrementing from 300 to 200 milliseconds in increments of 10 milliseconds every three beats for 10 seconds. Inducibility was defined as any sustained AF or organized atrial tachycardia (AT) lasting >30 seconds.ResultsWe had AF/AT inducibility in 55 patients at baseline compared to 36 following ablation. After a mean of 41, 3 months follow‐up, 115 patients were free of AF. Inducibility before or after the ablation or change in inducibility status did not influence AF recurrence. There were no significant differences regarding paroxysmal or persistent patients with AF.ConclusionsNon‐inducibility of atrial arrhythmia or change in inducibility status following pulmonary vein (PV) isolation and substrate modification are not associated with long‐term freedom from recurrent arrhythmia. Therefore, the use of induction of an endpoint in AF ablation is limited.
Optimization of the porcine liver enzymatic hydrolysis conditions
Authors: Maluf José U. , Fiorese Mônica L. , Maestre Keiti L. , Dos Passos Fernanda R. , Finkler Joana K. , Fleck Jessica F. , Borba Carlos E. 
Published: January 2020

AbstractWorldwide porcine slaughterhouses produce significant amounts of by‐products, such as porcine liver, daily. Even though the liver presents a very restricted market demand when raw, this product is composed of an exceptional nutritional content, with emphasis on protein, being, therefore, characterized as a potential raw material to produce protein hydrolysates. This article aimed to study the production of protein hydrolysate using the commercial enzymes Alcalase 2.4L™ and Novo Pro‐D™. For the development of this research, a central composite rotatable design with 4 axial points was applied for each enzyme. The factors evaluated were protein/water and enzyme/substrate ratios. The best hydrolysis results indicate average percentages of hydrolysis degree of 27.5% for both enzymes. The presence of low‐molecular‐weight peptides was also evidenced by the electrophoresis technique. It is, therefore, concluded that there is positive viability for the use of hydrolyzed porcine liver in differentiated food applications with an aggregate market value.Practical ApplicationsAt present, the worldwide growing dissemination of food scarcity has become a stimulus for the food industry to rethink the efficient use of raw materials to avoid waste and maximize the use of existing nutritional resources. A potential way of exploiting the nutritional value of the protein by‐products with no commercial applications is their transformation into protein hydrolysates by means of enzymatic processes. Protein hydrolysates have been in focus in the scientific community with industrial applications as beneficial products to the ingesting body, for acting as either nutraceuticals or functional bioactive foods. Commercialization of this type of product has become a growing market niche. Thus, this research, which presents an investigation regarding the conditions of the porcine liver hydrolysis, fits within current issues, with innovative potential of obtainment of bioactive peptides from by‐products.
The impacts of water and ethanolic extracts of propolis on vacuum packaged sardine fillets inoculated with Morganella psychrotolerans during chilly storage
Authors: Yazgan Hatice , Burgut Aykut , Durmus Mustafa , Kosker Ali Rıza 
Published: January 2020

AbstractThe impacts of water and ethanolic extracts of propolis at a dose of 0.4 or 0.8% on vacuum packaged sardine fillets inoculated with Morganella psychrotolerans DSM 17886 during storage at 3 ± 1°C for 15 days were investigated. All fish groups were inoculated with M. psychrotolerans (108 cfu/ml) at a rate of 1%. Sensory, colorimetric, chemical analysis (total volatile basic nitrogen, thiobarbituric acid, peroxide values, and free fatty acids), pH value, and microbiological analysis (viable mesophilic and psychrophilic bacteria, coliform, and lactic acid bacteria count) were carried out. An enhance in L* values was found in the group treated with 0.8% ethanolic extracts of propolis on the seventh day of the storage. Application of propolis extract on fish fillets significantly inhibited bacterial growth during storage and extended shelf life of sardine for 4 and 6 days by the use of water extract and for 8 days by the use of ethanolic extract at doses of 0.4 and 0.8%, respectively. The result of the study revealed that application of propolis extracts, mainly ethanolic propolis extracts on sardine fillets resulted in lower lipid oxidation and bacterial growth, therefore, could be natural food additive for preservation of fish fillets.
The Euro Area Bond Free Float and the Implications for QE
Authors: BLATTNER TOBIAS S. , JOYCE MICHAEL A. S. 
Published: January 2020

AbstractThis paper examines how shocks to government bond duration risk held by price‐sensitive investors affect the euro area term structure of interest rates and the wider macroeconomy. We construct a new measure of the bond “free float,” which adjusts total debt for foreign official holdings and weights by residual maturity. Using a small macrofinance Bayesian Vector Autoregression (VAR) model, we estimate that the first round of asset purchases under the European Central Bank's (ECB) public sector purchase program reduced euro area 10‐year bond yields by around 30 bps in 2015. The positive impact on the output gap and inflation in 2016 was about 0.2 and 0.3 ppt, respectively.
Identifying possible risk factors for cesarean scar pregnancy based on a retrospective study of 291 cases
Authors: Zhou XianYi , Li Hua , Fu XiaoDong 
Published: January 2020

AbstractAimCesarean scar pregnancy (CSP) is a rare but life‐threatening type of ectopic pregnancy. This study's aim is to investigate the clinical characteristics and possible risk factors for cesarean scar pregnancy.MethodsA clinically randomized, unpaired and retrospective case–control study was implemented. A study group of 291 CSP patients and a control group of 317 full‐term pregnant women with a history of cesarean section (CS) were recruited in our hospital from May 2013 to October 2018. Their demographic characteristics and medical and obstetric history were collected.ResultsOnly symptoms suggestive of an impending abortion, such as vaginal bleeding with or without abdominal pain, were identified as the clinical characteristics of CSP. Maternal age older than 35 years, gravidity higher than 3 (especially gravidity higher than 5), more than two induced abortions (especially more than five abortions), an interval of less than 5 years (especially less than 2 years) between the current pregnancy and the last CS, history of CS performed in a rural hospital, history of induced abortions after CS and retroposition of the uterus were possible independent risk factors for CSP.ConclusionCSP is a result of a combination of multiple factors associated with CS. There are no unique early clinical features of CSP. As a unique type of ectopic pregnancy, early diagnosis, early termination and early clearance should be the treatment principles. Further research is needed to evaluate the relationship between the cesarean scar defect and CSP in the future.
Effect of Denture Cleansing Solutions on the Retention of Locator Attachments Over Time
Authors: Ayyıldız Simel , Şahin Cem , Emir Faruk , Ersu Bahadır 
Published: January 2020

AbstractPurposeTo evaluate and compare the alterations in retention of three Locator attachments after immersion in various denture cleansers at defined time intervals.Materials and MethodsTwo implants were embedded in an acrylic block. Pink, blue, and clear Locator attachments (n = 10 for each subgroup) were immersed into three different cleansing solutions (Corega, Protefix and NaOCl) and tap water (control) at different time intervals that simulate 1 (T1), 6 (T2), and 12 (T3) months of clinical use. Universal testing machine set at a crosshead speed of 50 mm/min was used for pull‐out tests. After the immersion procedure, the peak force to dislodgement was recorded to demonstrate the changes in retention of Locator attachments. Data were analyzed using repeated‐measures ANOVA followed by Tukey's Honestly Significant Difference (HSD) tests (α = .05).ResultsAll denture cleansing solutions affected the retentive values of all Locator attachments at defined time intervals (F = 4.299, p = 0.001). NaOCl affected all groups significantly after 12‐month immersion time (p = 0.001). The least retention loss at all subgroups was observed in Corega for clear Locator attachments (106.17 ± 5.21 N). The difference in retention values for pink attachments were not statistically significant for tap water, Protefix and Corega immersion at all time intervals (p > 0.05). Following NaOCl (blue; 33.31 ± 4.72 N, clear; 52.3 ± 8.5 N), tap water decreased the retention value of blue (41.14 ± 3.93 N) and clear (76.72 ± 8.42 N) Locator attachments at T3. Corega caused the least retention loss to clear attachments at T1 (106.17 ± 3.55 N).ConclusionThe retention of Locator attachments decreases over time after exposure to various denture cleansing solutions. As NaOCl significantly decreased the retentive values of all attachments, patients must be informed about that disadvantage. Also, tap water remarkably decreased retentive ability of all attachments. Periodic addition of an effervescent tablet into tap water may be recommended to patients that wear implant retained overdentures with Locator attachments.
Endogenous lipoid pneumonia associated with pulmonary neoplasia in three dogs
Authors: Pérez‐Accino J. , Liuti T. , Pecceu E. , Cazzini P. 
Published: January 2020

Endogenous lipoid pneumonia is a poorly characterised condition in veterinary medicine, particularly in dogs, but it is well recognised in association with lung neoplasia in humans. This case series describes three unique cases of endogenous lipoid pneumonia associated with lung neoplasia, including clinical, imaging, cytological findings and outcome. Clinical presentation and imaging lesions can appear non‐specific and may be obscured by neoplastic infiltrate and so diagnosis requires cytology or histopathology. Awareness of endogenous lipoid pneumonia in dogs with pulmonary neoplasia has an impact on staging and monitoring, treatment of clinical signs and quality of life and also aids appropriate use of antimicrobials.
The impact of social jetlag and chronotype on attention, inhibition and decision making in healthy adults
Authors: McGowan Niall M. , Uzoni Adriana , Faltraco Frank , Thome Johannes , Coogan Andrew N. 
Published: January 2020

AbstractSleep and circadian clock disruption are associated with neuropsychiatric disorders, such as attention deficit hyperactivity disorder, but the impact on neurocognitive performance is unclear. We assessed whether chronotype and everyday circadian misalignment manifested as social jetlag were associated with inter‐individual neurocognitive performance across domains of attention, inhibitory control and decision making. One hundred and eighty‐eight healthy young adults were assessed for sleep and circadian properties and performed two neurocognitive tasks, the Continuous Performance Test and the Iowa Gambling Task. Social jetlag was associated with significantly faster and less variable reaction times and commission errors on the Continuous Performance Test. Poorer subjective sleep quality was associated with poorer decision making on the Iowa Gambling Task. No effects were present for polymorphisms in the circadian clock genes CLOCK and PER3. We conclude that circadian disruption shaped by everyday environmental factors may impact on attentional/inhibitory performance but not on a measure of risky decision making.
Aniridia with PAX6 mutations and narcolepsy
Authors: Berntsson Shala Ghaderi , Kristoffersson Anna , Daniilidou Makrina , Dahl Niklas , Ekström Curt , Semnic Robert , Markström Agneta , Niemelä Valter , Partinen Markku , Hallböök Finn , Landtblom Anne‐Marie 
Published: January 2020

AbstractPAX6 gene mutations cause a variety of eye and central nervous system (CNS) abnormalities. Aniridia is often accompanied by CNS abnormalities such as pineal gland atrophy or hypoplasia, leading to disturbed circadian rhythm and sleep disorders. Less is known on the coincidence of narcolepsy in this patient group. We aimed to find out whether the circadian rhythm or sleep–wake structure was affected in patients with aniridia. Four members of a family segregating with congenital aniridia in two generations were included in the study. The patients were subjected to genetic testing for a PAX6 mutation, multiple sleep latency test, whole‐brain magnetic resonance imaging (MRI), hypocretin‐1 in cerebrospinal fluid, and Human Leukocyte Antigen DQ beta1*06:02. All four members were heterozygous for the pathogenic c.959‐1G>A mutation in the PAX6 gene. Sleep disturbance was observed in all family members. The index patient was diagnosed with narcolepsy. MRI showed a hypoplastic pineal gland in all members. We describe the first case of a patient with PAX6 haploinsufficiency, aniridia and pineal gland hypoplasia diagnosed with narcolepsy type‐1, suggesting a complex sleep disorder pathogenesis.
Encounters between children's nurses and culturally diverse parents in primary health care
Authors: Belintxon Maider , Dogra Nisha , McGee Paula , Pumar‐Mendez Maria Jesus , Lopez‐Dicastillo Olga 
Published: January 2020

AbstractThe objective of this study was to analyze the healthcare encounters between nurses and parents of different cultural backgrounds in primary health care. An ethnographic study was carried out using participant observations in health centers and interviews with nurses. Data were analyzed using thematic content analysis and constant comparative method. Four main themes were identified when nurses met parents of other cultural backgrounds: lack of mutual understanding, electronic records hamper the interaction, lack of professionals' cultural awareness and skills, and nurses establish superficial or distant relationships. The concepts of ethnocentrism and cultural imposition are behind these findings, hampering the provision of culturally competent care in primary health services. There were difficulties in obtaining and registering culturally related aspects that influence children's health and development. This was due to e‐records, language barriers, and the lack of cultural awareness and skills in health professionals making the encounters difficult for both nurses and parents. These findings show that there is a clear threat for health equity and safety in primary care if encounters between nurses and parents do not improve to enable nursing care to be tailored to any individual family needs.
A Case for Moral History – Universality and Change in Ethics after Wittgenstein
Authors: Hämäläinen Nora 
Published: January 2020

AbstractIn this paper, I raise the question of how the tradition of ethics after Wittgenstein tends to neglect the historicity of morality, in a way which is not representative of the complexity of Wittgenstein’s own thinking. I analyse a tendency towards one‐sidedness in the preferred diet of philosophical examples, where focus lies on recognition of, and ethical attentiveness to, a fellow person or creature. Although these examples play an important role in their own right, the overuse of such examples, along with a certain notion of “philosophical grammar”, detracts from a historically sensitive investigation of our ethical forms of life.
Dementia palliative care in the acute psychiatric hospital: A feasibility study
Authors: Gentry Melanie T. , Clark Matthew M. , Ryan Susan M. , Rummans Teresa A. , Lapid Maria I. 
Published: January 2020

AbstractPurposeWe explored the feasibility of a clinical pathway to identify hospitalized patients with dementia who would benefit from a palliative intervention.Design and MethodsConsecutive geropsychiatric admissions were screened for terminal dementia to be randomized to a palliative consultation vs usual care.FindingsA total of 43 of the 188 patients (23%) had dementia; however, dementia stages were severe but not terminal. The pathway was not feasible because of the lack of the target population in the inpatient setting for the intervention.Practice ImplicationsNew clinical pathways are needed to identify patients with dementia who would benefit from palliative care.
District nurses’ views on and experiences with a telemedicine educational programme in palliative care
Authors: Bauer Eithne Hayes , Bollig Georg , Dieperink Karin B. 
Published: January 2020

BackgroundMedical advancements, limited resources and shifting demographics have increased the number of patients with palliative care needs in primary care. To address educational needs, the specialised palliative care team of South Jutland, Denmark, created a telemedicine educational programme in palliative care to empower district nurses.AimThe study aimed to explore district nurses’ views on and experiences with a telemedicine educational programme in palliative care.Research methodsA qualitative explorative study based on interpretive description was conducted. Data collection consisted of four focus group interviews with district nurses from three municipalities, supplemented by participant observations and a focus group interview with teachers from the specialised palliative care team. Data were analysed using predominately inductive thematic analysis.ResultsDistrict nurses (n = 15) who participated in the programme and members of the specialised palliative care team (n = 6) who taught the programme were included. Analysis revealed the following advantages: reaffirming and updating existing knowledge, reduced professional isolation and creation of a forum to promote knowledge dissemination. A disadvantage was limited interaction between teachers and district nurses, questioning suitability for teaching complex palliative care. Initial technical problems affected motivation to participate. Organisational support differed between participating municipalities resulting in varying degrees of programme integration. Despite advantages of IT‐expert‐led sessions, key‐nurse‐led sessions in smaller groups proved more beneficial, suggesting a combination of IT support and key‐nurse management to maximise benefits.ConclusionThe use of an inter‐professional telemedicine educational programme to teach palliative care to district nurses is beneficial. However, programmes should be designed for interactivity and address varying educational needs. Key‐nurse roles require managerial and IT support to optimise knowledge dissemination. Further research on implementation of telemedicine education in palliative care is needed.
Optimal Mini Segway Control Using Non-Minimum Phase Sample and Hold Input
Authors: Wang Yingxu , Zhu Guoming G. 
Published: January 2020

Abstract
Our early work shows the reduction of feasible sampling period when sample and hold inputs (SHI) are used to convert a continuous-time non-minimum phase (NMP) system to a discrete-time minimum phase (MP) system, comparing to conventional zero-order hold. Consequently, high-gain discrete-time controllers can be designed and used to improve continuous-time NMP system performance since the resulting discrete-time system is MP. This paper demonstrates the performance improvements of a mini Segway robot through experiments utilizing a dual-loop control architecture. An inner-loop continuous-time controller stabilizes the mini Segway robot and the outer-loop discrete-time controller, designed based on the discrete-time MP system, is used to improve the overall system performance. Experimental results show that the mini Segway cart oscillation magnitudes are significantly reduced and its stability is also improved. This study also confirms the feasibility of implementing the SHI into a low cost microcontroller such as Arduino. That is, the additional computational load of SHIs is minimal.
Adolescents with chronic disease and social media: a cross-sectional study
Authors: De Nardi Laura , Trombetta Andrea , Ghirardo Sergio , Genovese Maria Rita Lucia , Barbi Egidio , Taucar Valentina 
Published: January 2020

ObjectiveThis study aims to explore the attitude of adolescents with chronic diseases toward social media exposure, focusing in particular on Facebook.DesignCross-sectional study.SettingAn anonymous semistructured survey was distributed to an Italian hospital-based cohort of adolescents with chronic disease to explore the role of Facebook in their daily life.PatientsWe recruited 212 adolescents (aged between 13 and 24 years) with a diagnosis of inflammatory bowel disease, coeliac disease, diabetes mellitus type 1 and cystic fibrosis.ResultsTwo hundred and seven of the 212 (97.6%) expressed the need of sharing their illness experience with friends, 201 out of 212 (94.8%) usually searched information on the internet to find new therapies and to discover their prognosis. One hundred and forty-nine out of 212 adolescents (70.3%) perceived dependence on their parents as the most negative aspect of having a chronic disease, and 200 out of 212 (94.3%) were looking for friends with the same disease on Facebook. Two hundred and ten out of 212 (99.1%) did not want their doctors or nurse on their social media platforms. During the active disease periods, the time spent with social media increased from an average of 5 to 11 hours.ConclusionsThis descriptive analysis focused on the Facebook impact on chronic disease perception among affected adolescents. It showed that they used to spend an increased amount of time on this platform during disease flare-up and highlighted their wish of keeping doctors and nurses away from their social dimension.