bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morbidity and mortality in carriers of the cystic fibrosis mutationCFTRPhe508del in the general population
Authors: Çolak Yunus , Nordestgaard Børge G. , Afzal Shoaib 
Published: May 2020

Cystic fibrosis (CF) is caused by autosomal-recessive inheritance of a dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR), up to 90% due to Phe508del mutation in theCFTRgene. We tested the hypothesis thatCFTRPhe508del carriers have increased morbidity and mortalityversusnon-carriers in the general population.We genotyped 108 035 randomly selected white Danish individuals from the Copenhagen General Population Study (aged from 20–100 years) forCFTRPhe508del mutation (rs113993960). Risk of chronic bronchitis and airflow limitation was assessed cross-sectionally. Overall survival and risk of bronchiectasis, lung cancer, pneumonia, chronic rhinosinusitis, airway bleeding, spontaneous pneumothorax, respiratory failure, acute and chronic pancreatitis, liver cirrhosis, ileus, gastric and colorectal cancer, and male infertility were assessed prospectively during up to 15 years of follow-up (median: 9 years). A single individual was excluded due to homozygosity forCFTRPhe508del and known CF. No other individuals had diagnosed CF at baseline examination or during follow-up.Among the resulting 108 034 individuals, 105 176 (97%) were non-carriers and 2858 (3%) were carriers (i.e.were heterozygous forCFTRPhe508del). Overall survival was similar between carriers and non-carriers. Compared to non-carriers and with multivariable adjustment, carriers had an odds ratio (OR) of 1.31 (95% CI 1.16–1.48) for chronic bronchitis, a hazard ratio (HR) of 1.88 (95% CI 1.03–3.45) for bronchiectasis and 1.52 (95% CI 1.12–2.08) for lung cancer. Carriers did not differ from non-carriers concerning lung function or any other morbidity outcomes as mentioned above.In the general population, carriers ofCFTRPhe508del have a normal lifespan but an increased risk of chronic bronchitis (1.3-fold), bronchiectasis (1.9-fold) and lung cancer (1.5-fold).
A case report of one vasovagal syncope patient with third-degree atrioventricular block caused by SCN5A gene mutation and literature review
Authors: Gao Lu , Yu Xia , Li Hongxia , Yuan Yue 
Published: May 2020

Abstract
Background
Vasovagal syncope (VVS) is common in children and significantly affects their quality of life. To our knowledge, this the first case report of SCN5A gene mutation associated with VVS and third-degree atrioventricular block (atrioventricular block, AVB), which could help pediatricians aware that VVS is not always a benign condition and help to identify VVS children at the risk of sudden death.

Case presentation
A twelve-year-old male child was admitted to Beijing Children’s Hospital of Capital Medical University for chest tightness for 9 days and syncope in July 2018. The child was diagnosed as VVS with third-degree AVB after complete investagations. A heterozygous mutation in the exon coding region of the SCN5A gene, C. 5851G > T (coding region 5551 nucleotide changed from G to T), was detected in the peripheral blood of the child. Electrophysiological examination and modified vagal ganglion radiofrequency ablation were performed in the child. The ECG playback was normal on the second day after operation. Holter showed no abnormality and no chest tightness or syncope occurred after 3 months and 1 year follow-up.

Conclusions
Our case report firstly reported that SCN5A mutation contributed to the pathogenesis of VVS with third-degree AVB. Vagal ganglion modified ablation have obtained good therapeutic effect. Gene analysis was of great value to the accurate diagnosis and treatment of VVS children.
HE4 overexpression decreases pancreatic cancer Capan-1 cell sensitivity to paclitaxel via cell cycle regulation
Authors: Guo Fengbiao , Li Jinping , Qi Yaozhi , Hou Jianqing , Chen Haibin , Jiang Shi-Wen 
Published: May 2020

Abstract
Background
Paclitaxel is a first-line chemotherapy drug for pancreatic, ovarian, endometrial cancers and other malignancies. However, its efficacy is often compromised by decreased cell sensitivity or the development of resistance. Human epididymis protein 4 (HE4) is highly expressed in gynecologic and pancreatic cancer tissues, and its serum levels are used for patient triage and assistant diagnosis of gynecologic cancers. Previous studies have shown that HE4 overexpression could promote cancer cell proliferation and the growth of tumor xenografts, which suggests its potential involvement in cancer chemosensitivity.

Methods
Two pancreatic cancer cell lines, Capan-1 and Suit-2, were transiently transfected with an HE4 overexpression plasmid, and transfected cells were treated with paclitaxel. S-phase cells were labeled using BrdU, and cell positivity rates were determined by counting BrdU-positive cells. Following HE4 overexpression and/or drug treatment, a western blotting analysis was performed to determine the protein alterations of PCNA and p21, two important cell cycle regulators.

Results
HE4 overexpression not only promoted the proliferation of the Capan-1 pancreatic cells, but also significantly decreased cell sensitivity to paclitaxel. Results from western blotting showed that paclitaxel inhibited cell proliferation by decreasing the expression of PCNA and increasing the expression of p21. Data analysis indicated interactive actions between HE4 function and paclitaxel effects, both converging to cell cycle regulation.

Conclusion
These findings suggest that HE4 could be a potential therapeutic target for the sensitization of pancreatic cancer cells to paclitaxel treatment. HE4 expression levels may be used to predict the sensitivity of pancreatic cancer patients to paclitaxel.
Challenges and burden of the Coronavirus 2019 (COVID-19) pandemic for child and adolescent mental health: a narrative review to highlight clinical and research needs in the acute phase and the long return to normality
Authors: Fegert Jörg M. , Vitiello Benedetto , Plener Paul L. , Clemens Vera 
Published: May 2020

AbstractBackgroundThe coronavirus disease 2019 (COVID-19) is profoundly affecting life around the globe. Isolation, contact restrictions and economic shutdown impose a complete change to the psychosocial environment in affected countries. These measures have the potential to threaten the mental health of children and adolescents significantly. Even though the current crisis can bring with it opportunities for personal growth and family cohesion, disadvantages may outweigh these benefits. Anxiety, lack of peer contact and reduced opportunities for stress regulation are main concerns. Another main threat is an increased risk for parental mental illness, domestic violence and child maltreatment. Especially for children and adolescents with special needs or disadvantages, such as disabilities, trauma experiences, already existing mental health problems, migrant background and low socioeconomic status, this may be a particularly challenging time. To maintain regular and emergency child and adolescent psychiatric treatment during the pandemic is a major challenge but is necessary for limiting long-term consequences for the mental health of children and adolescents. Urgent research questions comprise understanding the mental health effects of social distancing and economic pressure, identifying risk and resilience factors, and preventing long-term consequences, including—but not restricted to—child maltreatment. The efficacy of telepsychiatry is another highly relevant issue is to evaluate the efficacy of telehealth and perfect its applications to child and adolescent psychiatry.ConclusionThere are numerous mental health threats associated with the current pandemic and subsequent restrictions. Child and adolescent psychiatrists must ensure continuity of care during all phases of the pandemic. COVID-19-associated mental health risks will disproportionately hit children and adolescents who are already disadvantaged and marginalized. Research is needed to assess the implications of policies enacted to contain the pandemic on mental health of children and adolescents, and to estimate the risk/benefit ratio of measures such as home schooling, in order to be better prepared for future developments.
Ultrasound measurement of optic nerve sheath diameter pre- and post-lumbar puncture
Authors: Schott Christopher K. , Hirzallah Mohammad I. , Heyman Rock , Lesky Daniel N. , Brant Emily B. , Callaway Clifton W. 
Published: May 2020

Abstract
Background
To test the hypothesis that optic nerve sheath diameter (ONSD) correlates with real-time changes in intracranial pressure, we performed ultrasound measurements of the ONSD in ambulatory patients undergoing elective lumbar puncture (LP). We conducted a prospective cohort study, including adult patients undergoing LP in a non-emergent setting. We measured ONSD perpendicular to the optic nerve at 3 mm behind the globe in both eyes in the traverse and sagittal planes, with the patient supine. The primary outcome was change in ONSD from pre-LP to post-LP. We calculated association of opening and closing LP pressures with changes in the pre- and post-LP ONSD measurements.

Results
The mean patient age was 49.0 years (SD = 37–61, range 19–67) with 21 females (72.4%) and 26 (89.7%) white American (not Hispanic or Latino). The average opening pressure and closing pressures were 20.4 cm and 13.5 cm with a difference of 6.9 cm, (95% CI 3.9–10.0 cm). Pressures between the participants with baseline ONSD measurement > 5 mm (average opening pressure = 21.3 cm) to those < 5 mm (20.2 cm) differed by 1.1 cm (95% CI − 5.7 to 8.0). Linear regression revealed no association between the sagittal, transverse, average, and change in ONSD measurements with the observed LP opening pressure, change in LP pressure, or volume of cerebral spinal fluid (CSF) drained.

Conclusions
In this study of ambulatory patients undergoing rapid decreases in ICP via elective LP, we detected no acute changes in ultrasonographic measurement of the ONSD.
Geometry of color perception. Part 1: structures and metrics of a homogeneous color space
Authors: Provenzi Edoardo 
Published: May 2020

AbstractThis is the first half of a two-part paper dealing with the geometry of color perception. Here we analyze in detail the seminal 1974 work by H.L. Resnikoff, who showed that there are only two possible geometric structures and Riemannian metrics on the perceived color space$\mathcal{P} $Pcompatible with the set of Schrödinger’s axioms completed with the hypothesis of homogeneity. We recast Resnikoff’s model into a more modern colorimetric setting, provide a much simpler proof of the main result of the original paper, and motivate the need of psychophysical experiments to confute or confirm the linearity of background transformations, which act transitively on$\mathcal{P} $P. Finally, we show that the Riemannian metrics singled out by Resnikoff through an axiom on invariance under background transformations are not compatible with the crispening effect, thus motivating the need of further research about perceptual color metrics.
Determinants of gross domestic savings in Uganda: an autoregressive distributed lag (ARDL) approach to cointegration
Authors: Nagawa Vivian , Wasswa Francis , Bbaale Edward 
Published: May 2020

AbstractIn Uganda’s development aspiration “VISION 2040”, Uganda aspires to transform its society from a peasant to a modern and prosperous middle-income country by 2040, with per capita income of USD 9, 567. To attain the vision, savings as a percentage of GDP should be over 35%. Notwithstanding such a high commitment, GDS as a percentage of GDP has remained below the desired target, standing at 16.5% in 2017. This paper investigated the determinants of Gross Domestic Savings (GDS) in Uganda for the period 1980–2017. The theoretical framework is based on the life-cycle/permanent-income hypothesis. Augmented Dickey Fuller and Phillips–Perron tests were utilized to test for the stationarity of the time series variables in the model. To test for both the short-run and long-run relationships among GDS and the independent variables, the ARDL bounds testing approach was adopted. The observational results indicate that in the long run, Gross Domestic Product growth rate (GDPg), Foreign Domestic Investments (FDI) and Broad money (M2) have positive and statistically significant effects on GDS, while Current Account Balance (CAB) and Gross National Expenditure (GNE) have negative impacts on savings. Deposit Interest Rate (DIR) was observed to be a statistically unimportant determinant of GDS in Uganda. In the short run, CAB has a positive and statistically significant impact on GDS while GDPg and DIR have a negative and statistically significant impact on GDS. The paper recommends increasing net exports through implementation of the industrial and export strategy espoused in the national development plan 2. In addition, the government should ensure a predictable economic environment to act as an assurance to the foreign investors that their investments will yield profits.
Binary image description using frequent itemsets
Authors: Aznag Khalid , Datsi Toufik , El oirrak Ahmed , El bachari Essaid 
Published: May 2020

AbstractIn this paper, a novel method for binary image comparison is presented. We suppose that the image is a set of transactions and items. The proposed method applies along rows and columns of an image; this image is represented by all frequent itemset. Firstly, the rows of the image are considered as transactions and the columns of the image are considered as items. Secondly, we considered rows as items and columns as transactions. Besides, we also apply our technique to color image; firstly we segment the image and each segmented region is considered as a binary image. The proposed method is tested on the MPEG7 database and compared with the moment’s method to show its efficiency.
Turnitin peer feedback: controversial vs. non-controversial essays
Authors: Alharbi Mohammed Abdullah , Al-Hoorie Ali H. 
Published: May 2020

AbstractAlthough an important goal of learner peer feedback is promoting critical thinking, little attention has been paid to the nature of the topic, particularly whether it is controversial. In this article, we report on a study where 52 English majors were asked to comment on essays written by their peers using the PeerMark module of Turnitin. Half of the essays were about controversial topics in the Saudi society (e.g., women driving and banning cigarettes), whereas the other half were less controversial (e.g., importance of sleep and respecting parents). Our results showed that the participants provided significantly more critical, global comments on controversial essays. At the same time, this increase in global comments did not come at the expense of local, language-related comments—in that the participants did not provide significantly fewer language comments on controversial essays. The participants also reported favorable attitudes toward this task due to the convenience and anonymity of online feedback, thus allowing them to express their opinions more freely on controversial topics. We therefore concluded that utilizing an online platform that permits double-blind peer review on controversial essays seems to have to the potential to stimulate critical thinking among language learners.
Endobronchial ultrasound guided Echo Tip Ultra HD 22G needle versus Echo Tip Pro Core HD 22G needle in diagnosis of mediastinal lesions
Authors: Hussein Sabah Ahmed , Shalaby Alaa Eldein Omar , Kamel Khaled Mahmoud , Hareedy Amal Ahmad , Abdelhameed Hoda Mohamed Mahmoud 
Published: May 2020

Abstract
Background
Convex probe endobronchial ultrasound is a minimally invasive technique used for performing real-time transbronchial needle aspiration of enlarged hilar and mediastinal lymph nodes and could be used for diagnosing proximal peribronchial lesions. Although computed tomography, magnetic resonant imaging, and positron emission tomography/computed tomography have relatively high sensitivity for mediastinal evaluation, pathology is the gold standard. This study compared between Echo Tip Ultra HD-EBUS 22G needle and Echo Tip ProCore HD-EBUS 22G needle in diagnosis of mediastinal lesions using convex probe endobronchial ultrasound.

Results
Twenty-four patients with mediastinal lesions were included. Convex probe endobronchial ultrasound-guided transbronchial needle aspiration using both Echo Tip Ultra HD 22G and Echo Tip ProCore HD 22G needles was done to all patients with no peripheral lymph node enlargement. CP-EBUS TBNA had diagnostic accuracy 50%, sensitivity 47.6%, and specificity 100% in diagnosis of mediastinal lesions. The Echo Tip Ultra HD needle had diagnostic accuracy 40.9%, sensitivity 38%, and specificity 100% compared to the Echo Tip ProCore HD needle which had diagnostic accuracy 31.8%, sensitivity 82.5%, and specificity 100%. The difference between both needles was statistically insignificant. The Echo Tip Ultra 22G HD needle had more representative cellularity (82%) compared to the Echo Tip ProCore 22G HD needle (45%) with a significant difference between both needles (p value = 0.001).

Conclusion
Both needles can be used equally in sampling mediastinal lesions. This study supports that Echo Tip Ultra HD and Echo Tip ProCore HD needles can be used equally in sampling of mediastinal lesions and supports ultrasound screening of enlarged supraclavicular and cervical lymph nodes before performing EBUS-TBNA in patients with mediastinal lesions.
Production and Characteristics of Biomass for Arundo donax, Pennisetum purpureum, and P. purpureum × P. glaucum in a Short-Rotation Crop System in Humid Tropical Conditions in Costa Rica
Authors: Salazar-Zeledón Estephanía , Gaitán-Alvarez Johana , Moya Róger 
Published: May 2020

HighlightsArundo donax, Pennisetum purpureum, and P. purpureum × P. glaucum planted at 103 plants ha-1 were studied.Biomass production and energy characteristics were evaluated at 12, 18, 24, and 30 months.The production of dry biomass varied between 2.52 and 39.25 Mg ha-1.The biomass quality and production of Arundo donax were different from those of Pennisetum ssp.Abstract.The high global demand for fossil fuels has led to the search for alternative sources of renewable energy, such as the production of biomass from short-rotation crops (SRC). This study evaluated three grass species (, , and × ) in SRC systems planted at 103 plants ha-1 in humid tropical conditions in Costa Rica, considering biomass production, moisture content, and energy and chemical properties at four harvest ages (12, 18, 24, and 30 months). The results showed that the height of all species varied between 0.9 and 3.5 m at the different harvests, while the production of dry biomass varied between 2.52 and 39.25 Mg ha-1. As for their chemical properties, the ash content varied between 5.9% and 10.2%, volatile matter varied between 73.3% and 81.9%, and net calorific value varied between 15.86 and 18.94 MJ kg-1. In the three species, the production of biomass was greater at the 12-month and 18-month harvests; at later harvests, biomass production began to decrease, leading to increased moisture and ash contents, lower volatile matter, and lower calorific value. The biomass quality and production of were different from those of . Keywords: Bioenergy, Energetic potential, Forage, Pastures, Short-rotation plantations, Tropical species.
A Case Study on the Relevance of the Journal Impact Factor
Authors: Fox Garey A. , Fox Amanda K. , Guertault Lucie 
Published: May 2020

HighlightsPublication profiles of seven highly published authors were analyzed from Google Scholar profiles.Journal impact factor (JIF) not strongly correlated to citations in the first two years after publication.Significant correlation between the number of citations in the first two years and total citations to an article.More important to submit manuscripts to journals with appropriate readership than the highest JIF.Abstract. In today’s world of research publishing, authors are typically encouraged to submit manuscripts to journals with the highest possible journal impact factor (JIF). This approach inherently assumes that the higher the JIF, the more likely the article will be cited. However, calls to move away from the JIF are becoming more common. This study analyzes the publication profiles of seven authors who are members of the Natural Resources and Environmental Systems (NRES) community of the American Society of Agricultural and Biological Engineers (ASABE) and who frequently publish in ASABE journals. This study hypothesized that statistically significant correlations existed between the JIF and the (1) total number of citations, (2) number of citations per year, and/or (3) number of citations in the first two years after publication. Based on 999 articles published by these seven authors from 1982 to 2018, statistically significant but fairly low to moderate correlations were observed between the JIF and the total citations, citations per year, and citations in the first two years after publication. The greatest correlation was observed between the number of citations that an article received in the first two years after publication and the number of citations per year (or the total number of citations). Therefore, ensuring an appropriate readership to generate short-term citations was more important than the JIF. When compared to high-JIF journals, there were statistically fewer citations per year and fewer citations in the first two years after publication for articles published in ASABE journals. While ASABE journal articles possess high citation longevity (i.e., cited half-life), efforts to immediately improve short-term metrics should focus on attracting high-quality research and improving article visibility. To extrapolate these findings to a wider community, future research should investigate these correlations for researchers in other ASABE technical communities and at various career stages. Keywords: Citations, Journal citation factor, Journal impact factor, Peer review, Research impact.
Treatment of Rare and Aggressive Pancreatic Carcinosarcoma
Authors: Quinn Patrick L. , Ohioma Donald , Jones Anja M.K. , Ahlawat Sushil K. , Chokshi Ravi J. 
Published: May 2020

ABSTRACT
A 42-year-old African American woman presented with 4 days of worsening midepigastric pain that radiated to her back. Computed tomography confirmed a diagnosis of acute pancreatitis and revealed a mass within the distal body and tail of the pancreas. After an endoscopic ultrasound with fine-needle aspiration yielding atypical cells suspicious for adenocarcinoma, the patient underwent an en bloc resection of the intra-abdominal mass with subtotal pancreatectomy, splenectomy, left colectomy, and left partial adrenalectomy. Histopathologic examination findings, in addition to immunohistochemical staining, revealed a diagnosis of pancreatic carcinosarcoma. Postoperatively, the patient has undergone 20 cycles of chemotherapy and has been transitioned to comfort measures at 16 months postoperatively because of progressive disease.
Endoscopic Management of Ganglioneuroma in the Stomach
Authors: Ghoneim Sara , Shah Aun , Han Karam , Cai Dan , Sandhu Dalbir 
Published: May 2020

ABSTRACT
Ganglioneuromas are rare benign tumors of neuroblastic origin that can occur anywhere along the sympathetic chain. They are rarely found in the gastrointestinal tract and can appear as solitary polypoid lesions or diffuse as part of a familial syndrome. They are often asymptomatic but may present with nonspecific symptoms depending on their anatomic location. They have no special endoscopic appearance and are diagnosed by histology and immunohistochemistry staining. We present a case of solitary gastric ganglioneuroma treated successfully with endoscopic resection.