bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cannabidiol induces osteoblast differentiation via angiopoietin1 and p38 MAPK
Authors: Kang Mi‐Ae , Lee Jongsung , Park See‐Hyoung 
Published: July 2020

AbstractIn this study, we report the potential of cannabidiol, one of the major cannabis constituents, for enhancing osteoblastic differentiation in U2OS and MG‐63 cells. Cannabidiol increased the expression of Angiopoietin1 and the enzyme activity of alkaline phosphatase in U2OS and MG‐63. Invasion and migration assay results indicated that the cell mobility was activated by cannabidiol in U2OS and MG‐63. Western blotting analysis showed that the expression of tight junction related proteins such as Claudin1, Claudin4, Occuludin1, and ZO1 was increased by cannabidiol in U2OS and MG‐63. Alizarin Red S staining analysis showed that calcium deposition and mineralization was enhanced by cannabidiol in U2OS and MG‐63. Western blotting analysis indicated that the expression of osteoblast differentiation related proteins such as distal‐less homeobox 5, bone sialoprotein, osteocalcin, type I collagen, Runt‐related transcription factor 2 (RUNX2), osterix (OSX), and alkaline phosphatase was time dependently upregulated by cannabidiol in U2OS and MG‐63. Mechanistically, cannabidiol‐regulated osteoblastic differentiation in U2OS and MG‐63 by strengthen the protein‐protein interaction among RUNX2, OSX, or the phosphorylated p38 mitogen‐activated protein kinase (MAPK). In conclusion, cannabidiol increased Angiopoietin1 expression and p38 MAPK activation for osteoblastic differentiation in U2OS and MG‐63 suggesting that cannabidiol might provide a novel therapeutic option for the bone regeneration.
The multifaceted role of PARP1 in RNA biogenesis
Authors: Eleazer Rebekah , Fondufe‐Mittendorf Yvonne N. 
Published: July 2020

AbstractPoly(ADP‐ribose) polymerases (PARPs) are abundant nuclear proteins that synthesize ADP ribose polymers (pADPr) and catalyze the addition of (p)ADPr to target biomolecules. PARP1, the most abundant and well‐studied PARP, is a multifunctional enzyme that participates in numerous critical cellular processes. A considerable amount of PARP research has focused on PARP1's role in DNA damage. However, an increasing body of evidence outlines more routine roles for PARP and PARylation in nearly every step of RNA biogenesis and metabolism. PARP1's involvement in these RNA processes is pleiotropic and has been ascribed to PARP1's unique flexible domain structures. PARP1 domains are modular self‐arranged enabling it to recognize structurally diverse substrates and to act simultaneously through multiple discrete mechanisms. These mechanisms include direct PARP1‐protein binding, PARP1‐nucleic acid binding, covalent PARylation of target molecules, covalent autoPARylation, and induction of noncovalent interactions with PAR molecules. A combination of these mechanisms has been implicated in PARP1's context‐specific regulation of RNA biogenesis and metabolism. We examine the mechanisms of PARP1 regulation in transcription initiation, elongation and termination, co‐transcriptional splicing, RNA export, and post‐transcriptional RNA processing. Finally, we consider promising new investigative avenues for PARP1 involvement in these processes with an emphasis on PARP1 regulation of subcellular condensates.This article is categorized under:
RNA Processing > Splicing Regulation/Alternative Splicing
Factors determining the surface oil concentration of encapsulated lipid particles: impact of the emulsion oil droplet size
Authors: Linke Annika , Weiss Jochen , Kohlus Reinhard 
Published: July 2020

AbstractMicroencapsulation of oxidation sensitive oils aims to separate lipids from the environmental oxygen by embedding oil droplets in a solid matrix, which builds a physical barrier. Some oil droplets are not fully incorporated and are in contact with the powder surface generating surface oil. It is proposed that the probability of oil droplets being in contact with the particle surface increases with the oil droplet size. The aim of the study is to investigate the impact of the oil droplet size on the encapsulation efficiency (EE). Two sets of feed emulsions differing in the applied homogenization pressure and in the protein to oil ratio were spray dried using a pilot plant spray dryer. The oil droplet size of the emulsion was determined by static light scattering (SLS). In addition, nuclear magnetic resonance (NMR) was used to measure the d3,2 of oil droplets in the emulsion and in the powder before and after surface oil removal. Encapsulates were analyzed regarding aw, moisture content, particle size, oil load and EE. The oil droplet size in the emulsion decreased with increasing protein to oil ratio as well as with the homogenization pressure. Large oil droplets and in particular droplet clusters resulted in more non-encapsulated oil. The experimentally determined EE was in accordance with the theoretical one, calculated based on the droplet and particle diameter. For emulsions with a diameter > 1 µm, the d3,2 decreased in the powder and further by removing the surface oil, which was related to the deformation of oil droplets contributing to the non-encapsulated oil.
Exploring contrast-enhanced MRI findings of the clinically non-inflamed symptomatic pediatric wrist
Authors: Verkuil Floris , van Gulik E. Charlotte , Nusman Charlotte M. , Barendregt Anouk M. , Nassar-Sheikh Rashid Amara , Schonenberg-Meinema Dieneke , Dolman Koert M. , Maas Mario , Kuijpers Taco W. , van den Berg J. Merlijn , Hemke Robert 
Published: July 2020

Abstract
Background
Knowledge of the synovial and tenosynovial appearance of the clinically non-arthritic symptomatic juvenile wrist using contrast-enhanced magnetic resonance imaging (MRI) is sparse.

Objectives
To analyze contrast-enhanced MRI findings of the clinically non-inflamed symptomatic pediatric wrist, focusing on the enhancing synovial and tenosynovial membrane. To evaluate the coexistent presence of (teno)synovial enhancement, joint fluid, bony depressions and medullary changes suggestive of bone marrow edema.

Materials and methods
We included 20 children (15 girls; age range: 7.5–17.6 years) who underwent contrast-enhanced MRI of the wrist, based on initial clinical indication, and eventually turned out to be unaffected by arthritic or orthopedic disorders. Various imaging characteristics of the synovium, tenosynovium, joint fluid, bone tissue and bone marrow were evaluated using existing MRI scoring systems.

Results
In 3/20 (15%) children, mild or moderate-severe synovial enhancement was observed and 2/20 (10%) children showed mild tenosynovial enhancement/thickening. Joint fluid (11/20 children; 55%), bony depressions (20/20 children; 100%) and medullary changes suggestive of bone marrow edema (6/20; 30%) were found in a substantial percentage of children. The most frequently observed combination of coexisting imaging characteristics was bony depressions with ≥2 mm joint fluid, which was found in 7/20 (35%) children. Simultaneous presence of synovial and tenosynovial enhancement/thickening, bony depressions and medullary changes suggestive of bone marrow edema was observed in one child.

Conclusion
Several juvenile idiopathic arthritis-relevant MRI characteristics can be observed in the clinically non-inflamed symptomatic pediatric wrist.
Impact of lordotic cages in the restoration of spinopelvic parameters after dorsal lumbar interbody fusion: a retrospective case control study
Authors: Oikonomidis Stavros , Heck Vincent , Bantle Sonja , Scheyerer Max Joseph , Hofstetter Christoph , Budde Stefan , Eysel Peer , Bredow Jan 
Published: July 2020

Abstract
Purpose
Aim of this study was to compare the reconstruction of radiological sagittal spinopelvic parameters between lordotic (10°) and normal cages (0°) after dorsal lumbar spondylodesis.

Methods
This retrospective monocentric study included patients who received dorsal lumbar spondylodesis between January 2014 and December 2018. Inclusion criteria were degenerative lumbar diseases and mono- or bi-segmental fusions in the middle and lower lumbar region. Exclusion criteria were long-distance fusions (3 segments and more) and infectious and tumour-related diseases. The sagittal spinopelvine parameters (lumbar lordosis, segmental lordosis, sacral slope, pelvic incidence, and pelvic tilt) were measured pre- and post-operatively by two examiners at two different times. The patients were divided into 2 groups (group 1: lordotic cage, group 2: normal cage).

Results
One hundred thirty-eight patients (77 female, 61 male) with an average age of 66.6 ± 11.2 years (min.: 26, max.: 90) were included in the study based on the inclusion criteria. Ninety-two patients (66.7%) received 0° cages and 46 (33.3%) lordotic cages (10°). Segmental lordosis was increased by 4.2° on average in group 1 and by 6.5° in group 2 (p = 0.074). Average lumbar lordosis was increased by 2.1° in group 1 and by 0.6° in group 2 (p = 0.378). There was no significant difference in the correction of sagittal spinopelvic parameters. Inter- and inter-class reliability was between 0.887 and 0.956.

Conclusion
According to the results of our study, no advantages regarding sagittal radiological parameters for the implantation of a lordotic cage could be demonstrated.
Development and validation of a classification algorithm to diagnose and differentiate spontaneous episodic vertigo syndromes: results from the DizzyReg patient registry
Authors: Groezinger Michael , Huppert Doreen , Strobl Ralf , Grill Eva 
Published: July 2020

Abstract
Background
Spontaneous episodic vertigo syndromes, namely vestibular migraine (VM) and Menière’s disease (MD), are difficult to differentiate, even for an experienced clinician. In the presence of complex diagnostic information, automated systems can support human decision making. Recent developments in machine learning might facilitate bedside diagnosis of VM and MD.

Methods
Data of this study originate from the prospective patient registry of the German Centre for Vertigo and Balance Disorders, a specialized tertiary treatment center at the University Hospital Munich. The classification task was to differentiate cases of VM, MD from other vestibular disease entities. Deep Neural Networks (DNN) and Boosted Decision Trees (BDT) were used for classification.

Results
A total of 1357 patients were included (mean age 52.9, SD 15.9, 54.7% female), 9.9% with MD and 15.6% with VM. DNN models yielded an accuracy of 98.4 ± 0.5%, a precision of 96.3 ± 3.9%, and a sensitivity of 85.4 ± 3.9% for VM, and an accuracy of 98.0 ± 1.0%, a precision of 90.4 ± 6.2% and a sensitivity of 89.9 ± 4.6% for MD. BDT yielded an accuracy of 84.5 ± 0.5%, precision of 51.8 ± 6.1%, sensitivity of 16.9 ± 1.7% for VM, and an accuracy of 93.3 ± 0.7%, precision 76.0 ± 6.7%, sensitivity 41.7 ± 2.9% for MD.

Conclusion
The correct diagnosis of spontaneous episodic vestibular syndromes is challenging in clinical practice. Modern machine learning methods might be the basis for developing systems that assist practitioners and clinicians in their daily treatment decisions.
Tools for the construction and analysis of systems
Authors: Beyer Dirk , Huisman Marieke 
Published: July 2020

AbstractIn order to develop reliable software and systems, we depend on practical techniques for the construction and analysis of such software and systems. This special issue of Software Tools for Technology Transfer presents various tool-supported techniques that can help with the construction and analysis of such reliable software and systems. The papers in this special issue are extended versions of selected conference papers from the proceedings of the 24th International Conference on Tools and Algorithms for the Construction and Analysis of Systems (TACAS 2018).
Facile low-temperature synthesis of nickel oxide by an internal combustion reaction for applications in electrochromic devices
Authors: Lupo Christian , Eberheim Florian , Schlettwein Derck 
Published: July 2020

Abstract
Electrochromic nickel oxide ion storage anodes compatible to tungsten oxide as cathode layer are prepared by a combustion reaction with urea as fuel and nickel nitrate as oxidizer at temperatures not higher than 230 °C to stay well within the temperature range in which thermally sensitive intercalated tungsten oxide layers are still stable. The precursors for nickel oxide are well available materials and the preparation of the layers can be performed at low energy input by spin-coating onto the substrate and moderate heating on a hot-plate. Ethanol and acetone where used as solvents and reveal large differences in the resulting film morphologies, electric and electrochromic characteristics. Cyclic voltammetry measurements in contact to lithium perchlorate (LiClO4) in propylene carbonate show remarkable colouration efficiencies at 550 nm of 47 cm2 C−1 for NiO prepared from ethanol solution and 92 cm2 C−1 for NiO prepared from acetone solution, which are, to the best of our knowledge, among the highest reported values for Li+-intercalation into NiO prepared at moderate substrate temperature reported so far.

Graphic abstract
Modelling Online Gaming Metacognitions: The Role of Time Spent Gaming in Predicting Problematic Internet Use
Authors: Caselli Gabriele , Marino Claudia , Spada Marcantonio M. 
Published: July 2020

AbstractIn recent years there have been growing concerns about problematic Internet use (PIU) as potential mental health problem. Among the many activities available on the Internet, the time spent gaming appears one of the most frequent risk factors in developing PIU. The aim of the current study was to model the relationship between negative affect, metacognitions about online gaming, frequency of online gaming and PIU. A total of 326 Italian gamers (mean age = 27 years, SD = 5.65 years; 93.3% males) participated in the study. The pattern of relationships specified by the theoretical model was examined through path analysis. Results showed that negative affect was directly associated with all other variables. Specifically, positive, strong and direct associations were found between negative affect and both positive and negative metacognitions about online gaming. Moreover, negative metacognitions about online gaming were strongly linked to PIU. Overall, the theoretical model was supported showing that metacognitions about online gaming may play a role in the association between time spent on online gaming to a broader pattern of PIU. Results are discussed within the context of the metacognitive model of psychopathology and clinical implications based on this model are outlined.
Note on Crystallization for Alternating Particle Chains
Authors: Bétermin Laurent , Knüpfer Hans , Nolte Florian 
Published: July 2020

AbstractWe investigate one-dimensional periodic chains of alternate type of particles interacting through mirror symmetric potentials. The optimality of the equidistant configuration at fixed density—also called crystallization—is shown in various settings. In particular, we prove the crystallization at any scale for neutral and non-neutral systems with inverse power laws interactions, including the three-dimensional Coulomb potential. We also show the minimality of the equidistant configuration at high density for systems involving inverse power laws and repulsion at the origin. Furthermore, we derive a necessary condition for crystallization at high density based on the positivity of the Fourier transform of the interaction potentials sum.
Evaluating gender equality effects in research and innovation systems
Authors: Bührer Susanne , Kalpazidou Schmidt Evanthia , Palmén Rachel , Reidl Sybille 
Published: July 2020

AbstractDespite the fact that the topic of “women in research and innovation” has been on the agenda for decades and numerous measures have been implemented at both national and supranational levels to improve gender equality in research and innovation systems, it is still unclear which measures and under which conditions these measures are most effective. Even less research has been carried out on the effects of better representation of women in terms of research and innovation. This paper is based on the application of an innovative evaluation framework, which encompasses complexity and theory of change approaches and aims at exploring the link between interventions and their subsequent effects to two case studies. We discuss two major German flagship programmes aiming at increasing the participation of female researchers in the science system, the “Women Professorship Programme” and the “Pact for Research and Innovation”. Through the two programmes, we tested and validated the evaluation framework and its indicators. As part of the validation process, a theory of change has been developed for each of the programmes. The theory-based evaluation approach helped not only to identify gender equality impacts but also broader effects on research and innovation that might have otherwise remained undetected. We studied the effects of the two programmes on the number of women in leadership positions and analysed whether an increase in the proportion of women leaders influences publication patterns. Although linear linkages are challenging to establish due to the complexity of the process, the findings suggest that the flagship programmes have contributed not only to higher shares of women researchers but also to improved female publication and citation rates. There are clear benefits for Germany in terms of scientific results from the increased proportion of female researchers in research and innovation.
Investigation on air quality of specific indoor environments—spa salons located in Gdynia, Poland
Authors: Pytel Klaudia , Marcinkowska Renata , Zabiegała Bożena 
Published: July 2020

AbstractDue to excessive application of essential oils and scented products in spa salons during aromatherapy and massage sessions, the elevated concentration of total volatile organic compounds (TVOCs), particularly terpenes, which are known as secondary organic aerosol (SOA) precursors, is expected there. This study was aimed at determination of VOCs with a particular regard to terpenes in air samples collected in selected spa salons located in Northern Poland. Active air sampling was conducted before and after treatments. Samples were analyzed with the use of thermal desorption gas chromatography coupled with flame-ionization detector (TD-GC-FID) and mass spectrometer (TD-GC-MS). Obtained results allowed to characterize chemical composition of indoor air of spa salons and also to relate the dependence between applied essential oil and indoor air chemical composition. It has been proved that (i) spa salons are characterized by TVOC concentrations exceeding recommended values of 300–400 μg m−3 in most of examined cases, reaching up to several thousand of micrograms per cubic meter, (ii) TVOC concentration is strictly related to salon characteristics and carried out treatments, (iii) terpenes constitute a significant part of TVOCs present in spa indoor air, from 22 up to 86%, (iv) most commonly investigated terpenes in the literature (d-limonene, α-pinene, camphene, and linalool) were also determined at the highest concentration levels in this study and (v) VOC chemical composition is strictly dependent on the type of applied essential oils. On the basis of obtained results, it may be stated that extensive application of essential oils rich in terpenes can significantly alter indoor air chemistry of spa salons, thereby influencing health and well-being of employees working there.
Examining the Relationship Between Digital Transformation and Work Quality: Substitution Potential and Work Exposure in Gender-Specific Occupations
Authors: Dengler Katharina , Tisch Anita 
Published: July 2020

AbstractComputers can substitute for many tasks currently performed by humans and are likely to change occupations in the near future. However, it is not likely that entire occupations will disappear. In this context, little attention has been paid to possible impacts of digital transformation on aspects of work quality. It would be desirable for changes to ease occupations with high work exposure. In this article, we assume that digital technologies may replace physically demanding jobs mainly performed by men, but not psychosocially demanding jobs mainly performed by women. Thus, the question arises whether social inequality between men and women may increase in the course of digital transformation. Using large-scale administrative and survey data from Germany, we analyse the relationship between digital transformation and work exposure for male- and female-dominated occupations. We measure the degree of digital transformation by occupation-specific substitution potential, that is the extent to which occupational tasks can be replaced by computers or computer-controlled machines. The results imply that digital technologies could relieve men of physically demanding jobs. However, we cannot find any evidence that digital technologies have already caused employment to decline in occupations with physical work exposure.
The Fate of Mud Nourishment in Response to Short-Term Wind Forcing
Authors: Schulz Kirstin , Klingbeil Knut , Morys Claudia , Gerkema Theo 
Published: July 2020

AbstractIn this study, results from a realistic 3D hydrodynamic and sediment transport model, applied to a channel in the Dutch Wadden Sea, are analyzed in order to assess the effect of short-term wind forcing, the impact of fresh water effects, and the variability induced by the spring-neap cycle on the transport of suspended sediment. In the investigated region, a pilot study for sediment nourishment, the so-called Mud Motor, is executed. This project aims for the beneficial re-use of dredged harbor sediments through the disposal of these sediments at a location where natural currents are expected to transport them toward a nearby salt marsh area. The model results presented in this study advance the understanding of the driving forces that determine sediment transport in shallow, near-coastal zones, and can help to improve the design of the Mud Motor. In the investigated channel, which is oriented parallel to the coastline, tidal asymmetries generally drive a transport of sediment in flood direction. It was found that already moderate winds along the channel axis reverse (wind in ebb direction), or greatly enhance this transport, up to an export of sediment over the adjacent water shed (wind in flood direction). The most beneficial wind conditions (moderate westerly winds) can cause an accumulation of more than 90% of the initial 200 tons sediment pool on the intertidal area; during less favorable conditions (northeasterly winds), less than a third of the dumped sediment is transported onto the mudflat. On-shore winds induce a transport toward the coast. Surprisingly, sediment pathways are only sensitive to the exact disposal location in the channel during wind conditions that counteract the tidally driven transport, and freshwater effects play no significant role for the dispersal of sediment.