bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal relationship between power and design-driving loads for wind turbine rotors using 1-D models
Authors: Loenbaek Kenneth , Bak Christian , Madsen Jens I. , Dam Bjarke 
Published: January 2020

Abstract. We investigate the optimal relationship between the aerodynamic power, thrust loading and size of a wind turbine rotor when its design is constrained by a static aerodynamic load. Based on 1-D axial momentum theory, the captured power P̃ for a uniformly loaded rotor can be expressed in terms of the rotor radius R and the rotor thrust coefficient CT. Common types of static design-driving load constraints (DDLCs), e.g., limits on the permissible root-bending moment or tip deflection, may be generalized into a form that also depends on CT and R. The developed model is based on simple relations and makes explorations of overall parameters possible in the early stage of the rotor design process. Using these relationships to maximize P̃ subject to a DDLC shows that operating the rotor at the Betz limit (maximum CP) does not lead to the highest power capture. Rather, it is possible to improve performance with a larger rotor radius and lower CT without violating the DDLC. As an example, a rotor design driven by a tip-deflection constraint may achieve 1.9 % extra power capture P̃ compared to the baseline (Betz limit) rotor. This method is extended to the optimization of rotors with respect to annual energy production (AEP), in which the thrust characteristics CT(V) need to be determined together with R. This results in a much higher relative potential for improvement since the constraint limit can be met over a larger range of wind speeds. For example, a relative gain in AEP of +5.7 % is possible for a rotor design constrained by tip deflections, compared to a rotor designed for optimal CP. The optimal solution for AEP leads to a thrust curve with three distinct operational regimes and so-called thrust clipping.
Posttraumatic Healing inCaesar's Things
Authors: Kim Sharon 
Published: January 2020

AbstractCaesar's Things, the unpublished religious novel by Zelda Fitzgerald, is considered a product of her mental disorder, yet it is rarely analyzed with the tools available through psychoanalytic theory. The often-remarked incoherence of the text becomes more legible when read in terms of psychological trauma instead of the vague idea of madness. At the literal center of the novel in chapter 4 are traces of an unrepresented trauma, which doubles and is screened by an explicitly described trauma in chapter 1, and whose repercussions affect the main character Janno throughout the novel. The narrative form itself exhibits features associated with posttraumatic experience, such as the centrality of death, the splitting of the self, the distortion of temporality, and the shattering of witness seen in failures of memory and language. Yet far from merely recording psychosis, the narrative frame consciously establishes a stabilizing architecture for these posttraumatic traits, adapting a clear structure derived from biblical motifs and decentering the psychiatrists represented in the manuscript. In Caesar's Things, Zelda Fitzgerald represents an unresolved wound to the psyche but indicates hope of healing in a future redemption.
Note on the regulation of veterinary medical devices in the EU: A review of the current situation and its impact on animal health and safety
Authors: Potockova H , Kusnierik P , Dohnal J 
Published: January 2020

AbstractMedical devices form a large heterogeneous group of products ranging from simple tools to medical testing and implants, the safety and efficacy of which are strictly regulated in all developed countries. Thanks to the health and cost benefits, medical devices have also found their way into veterinary medicine but, surprisingly, the regulation of these products is far less complex or, in some cases, missing altogether. Given the complexity and potential hazards of certain veterinary devices, the current state of affairs may lead to health and safety risks, both for animals and personnel involved. This review is the first to systematically map the current situation in the EU, revealing health and safety risks in practice for both animals and personnel involved and discussing them in a broader context. Only six out of the EU's 28 member states (Belgium, Croatia, Czech Republic, Germany, Hungary, and Slovakia) were found to have at least a degree of regulation of veterinary devices. As a result, a single product may be regulated as a veterinary medicinal product, a veterinary medical device or not be regulated at all, depending on the particular EU member state in question. As things stand, veterinary medicine makes use of all kinds of medical devices, including human products, regardless of their regulatory status and (pre-market) control. However, the use of such devices may influence the health and well-being of animals. Several measures are therefore suggested to attain the required levels of safety and efficacy surveillance for veterinary medical devices without creating excessive administration.
Bocángel’s Silva «El Retrato»: A Textual Trojan Horse? / La Silva «El Retrato», de Bocángel: ¿un caballo de Troya?
Authors: Mercado Leticia 
Published: January 2020

ABSTRACT: Gabriel Bocángel’s silva «El retrato» (c. 1638) is a textual Trojan horse in the war for poetic patronage in the early modern Spanish court. Written on the wedding of the poet’s cousin to Juan de Cetina, secretary to the Admiral of Castile, the poem is a verbal portrait of the bride that undermines not only the tradition of the descriptio puellae, but also the Count-Duke of Olivares’s power. As a panegyric of the latter’s enemy, the text employs the botanical images of the laurel and the ivy, exploiting the full sense of their symbolic meaning. As an appeal for the patronage of poetry and letters at court and an exercise in «self-fashioning» (Greenblatt), the text makes the lovers’ and the poet’s pursuits parallel to the «siege» of Daphne; the poet, as a new Apollo, sings and weaves a complex poetic fabric in which different tensions are ultimately resolved in the image of the Admiral’s laurelcrowned brow, to which both the couple’s and the poet’s ambitions aspire.
KEYWORDS
Bocángel; Patronage; Silva; Olivares; Baroque; Emblems.
RESUMEN: La silva «El retrato» (c. 1638) de Gabriel Bocángel es un caballo de Troya en la guerra por el patronazgo poético en el contexto de la corte española del siglo XVII. Escrita con motivo de la boda de la prima del poeta con Juan de Cetina, secretario del Almirante de Castilla, el poema es un retrato verbal de la novia que socava no sólo la tradición de la descriptio puellae, sino el poder del Conde-Duque de Olivares, enemigo acérrimo del Almirante. Como panegírico de este último, el texto emplea las imágenes botánicas del laurel y la hiedra explotando el pleno sentido de su significado emblemático y simbólico. Como petición de patronazgo de la poesía y las letras en la corte y como ejercicio de «self-fashioning» (Greenblatt), el texto pone en paralelo los objetivos de los amantes y del poeta con el acoso a Dafne; como nuevo Apolo, el poeta canta tejiendo un complejo tapiz en el que distintas tensiones se resuelven finalmente en la imagen de la frente del Almirante, coronada de laureles, a la que aspiran por igual las ambiciones de los amantes y del propio poeta.
The preferable ways of decision-making in IT teams
Authors: Krawczyk-Bryłka Beata , Krawczyk Henryk 
Published: January 2020

Software development team collaboration requires various decisions regarding essential aspects of a project’s progress. General and particular decision-making models are considered, and their main aspects such as team types, problem solving categories, and decision-making ways are analysed. The research concerns representative groups of IT specialists and their preferences in decision-making are investigated. Four possible cases were tested: hierarchical choice (by leader) team members' choice (team consensus or voting) and external expert impact. It allows one to show some differences in behaviors of traditional and virtual teams.
LINC00844 promotes proliferation and migration of hepatocellular carcinoma by regulating NDRG1 expression
Authors: Zhou Wei , Huang Kang , Zhang Qiuyan , Ye Shaojun , Zhong Zibiao , Zeng Cheng , Peng Guizhu , Li Ling , Ye Qifa 
Published: January 2020

Background
Aberrant expression of long noncoding RNAs are implicated in the pathogenesis of human malignancies. LINC00844 expression is dramatically downregulated in prostate cancer, and functional studies have revealed the association between the aberrant expression of LINC00844 and prostate cancer cell invasion and metastasis. However, the function and mechanism of action of LINC00844 in the pathogenesis of hepatocellular carcinoma (HCC) are poorly understood.

Methods
LINC00844 and N-Myc downstream-regulated 1 (NDRG1) expression in HCC tissues and cell lines was detected with real-time quantitative polymerase chain reaction (RT-qPCR) and western blot analysis. Correlations between LINC00844 expression level and clinicopathological features were investigated using the original data from The Cancer Genome Atlas (TCGA) database. HepG2 and HCCLM9 cell lines were transfected with Lv-LIN00844 virus to obtain LINC00844-overexpressing cell lines. Cell proliferation and cell invasion and migration were examined with the cell counting kit-8 (CCK-8) and transwell assay, respectively. Furthermore, the correlation between LINC00844 and NDRG1 expression was analysed using Pearson’s correlation analysis.

Results
LINC00844 expression was significantly downregulatedin HCC tissues and cell lines, and a statistical correlation was detected between low LINC00844 expression and sex (Female), advanced American Joint Committee on Cancer (AJCC) stage (III + IV), histological grade (G3 + G4), and vascular invasion (Micro and Macro). In vitro experiments showed that LINC00844 overexpression significantly repressed the proliferation, migration, and invasion of HCC cells. NDRG1 expression was higher in HCC tissues and LINC00844 could partly inhibit the expression of NDRG1.
Outreach to Promote Management of Cardiovascular Risk in Primary Care Among Patients With Rheumatoid Arthritis Seen in Rheumatology Practice
Authors: Persell Stephen D. , Lee Ji Young , Lipiszko Dawid , Peprah Yaw A. , Ruderman Eric M. , Schachter Michael , Majka Darcy S. 
Published: January 2020

ObjectiveRheumatoid arthritis (RA) confers a 1.5‐ to 2.0‐fold increased risk of cardiovascular disease (CVD). A prior multifaceted quality improvement approach to improving CVD preventive care increased CVD risk factor assessments, but there was no significant effect on the management of risk factors. We tested the impact of adding a proactive outreach strategy promoting primary care treatment of CVD risk factors among patients with RA through their rheumatology practice.MethodsThrough electronic health record searches, we identified patients with RA who were potential candidates for hypertension treatment initiation or intensification, statin therapy, or a smoking‐cessation intervention. A nonclinician care manager contacted patients by phone and mail on behalf of the rheumatologists, provided information about the identified risk factor(s), recommend follow‐up with primary care physicians (PCPs), sent correspondence to PCPs, and followed up with patients to see what actions had been taken. We measured preventive cardiology quality indicators and compared preintervention and intervention time periods using interrupted time series methods.ResultsDuring the 6‐month intervention period, the proportion of patients prescribed at least moderate‐intensity statin treatment for primary prevention rose from 18.4% to 23.8%. The rate of increase was 1.06% greater per month than during the preceding period (P < 0.001). Rates of increase in hypertension diagnosis and control improved more rapidly during this phase (P < 0.001 for each) and reversed preceding negative trends.ConclusionImplementing proactive nonclinician outreach to encourage primary care–based treatment of CVD risk factors was associated with increases in statin prescribing and in hypertension diagnosis and control. Smoking was not affected.
Highly Efficient and Color‐Stable Thermally Activated Delayed Fluorescence White Light‐Emitting Diodes Featured with Single‐Doped Single Emissive Layers
Authors: Ding Dongxue , Wang Zicheng , Li Chenyu , Zhang Jing , Duan Chunbo , Wei Ying , Xu Hui 
Published: January 2020

AbstractDespite their merits of environmental friendliness, low cost, and large‐scale production, thermally activated delayed fluorescence (TADF) based white organic light‐emitting diodes (WOLEDs) for daily lighting applications still face the formidable challenges of structural simplification and controllable exciton allocation. Here, the state‐of‐the‐art full‐TADF WOLEDs with features of the single‐doped single emissive layers (EMLs) and ultrasimple trilayer structure are demonstrated. The EMLs are binary systems as yellow TADF emitter (4CzTPNBu) doped blue TADF matrix (ptBCzPO2TPTZ) with the large steric hindrance and mismatched frontier molecular orbital energy levels to effectively restrain excessive blue‐to‐yellow triplet exciton transfer and host‐dopant interaction induced triplet quenching. Simultaneously, Förster resonance energy transfer is utilized to optimize exciton allocation for the balance of blue and yellow emissions, giving rise to the photoluminescence quantum yield beyond 90%. Consequently, these single‐doped EMLs endow their cool white, pure white, and warm white diodes with the high‐quality and ultrastable white light and the 100% exciton utilization efficiencies through the extremely simple structures, making them competent for the diverse daily lighting applications.
Contrasting environmental factors drive local adaptation at opposite ends of an environmental gradient in the yellow monkeyflower (Mimulus guttatus)
Authors: Popovic Damian , Lowry David B. 
Published: January 2020

PremiseIdentifying the environmental factors responsible for natural selection across different habitats is crucial for understanding the process of local adaptation in plants. Despite its importance, few studies have successfully isolated the environmental factors driving local adaptation in nature. In this study, we evaluated the agents of selection responsible for local adaptation of the monkeyflower Mimulus guttatus to California's coastal and inland habitats.MethodsWe implemented a manipulative reciprocal transplant experiment at coastal and inland sites, where we excluded aboveground stressors in an effort to elucidate their role in the evolution of local adaptation.ResultsExcluding aboveground stressors, most likely a combination of salt spray and herbivory, completely rescued inland annual plant fitness when transplanted to coastal habitat. The exclosures in inland habitat provided a benefit to the performance of coastal perennial plants. However, the exclosures are unlikely to provide much fitness benefit to the coastal plants at the inland site because of their general inability to flower in time to escape from the summer drought.ConclusionsOur study demonstrates that a distinct set of selective agents (aboveground vs. belowground) are responsible for local adaptation at opposite ends of an environmental gradient.
Solid‐State Emissive Aroyl‐S,N‐Ketene Acetals with Tunable Aggregation‐Induced Emission Characteristics
Authors: Biesen Lukas , Nirmalananthan‐Budau Nithiya , Hoffmann Katrin , Resch‐Genger Ute , Müller Thomas J. J. 
Published: January 2020

AbstractN‐Benzyl aroyl‐S,N‐ketene acetals can be readily synthesized by condensation of aroyl chlorides and N‐benzyl 2‐methyl benzothiazolium salts in good to excellent yields, yielding a library of 35 chromophores with bright solid‐state emission and aggregation‐induced emission characteristics. Varying the substituent from electron‐donating to electron‐withdrawing enables the tuning of the solid‐state emission color from deep blue to red.
Assessing the distribution pattern of otters in four rivers of the Indian Himalayan biodiversity hotspot
Authors: Gupta Nishikant , Tiwari Varun , Everard Mark , Savage Melissa , Hussain Syed Ainul , Chadwick Michael A. , Johnson Jeyaraj Antony , Nawab Asghar , Belwal Vinod K. 
Published: January 2020

Abstract

The Eurasian otter (Lutra lutra), smooth‐coated otter (Lutrogale perspicillata), and Asian small‐clawed otter (Aonyx cinereus) have all been reported previously from the Indian state of Uttarakhand. However, little information is available about their current distribution in a mountainous region that is subject to increasing human‐induced stressors (such as hydropower plants, pollution, sand and boulder mining, destructive fishing techniques, poaching).
Owing to important roles played by these otters in structuring riverine food webs (particularly taking account of their roles as top carnivores), it is critical that they receive suitable protection in the face of projected temperature rise, change in precipitation patterns, and associated river flows in this Himalayan biodiversity hotspot. This study assesses otter distribution in four rivers of Uttarakhand as a basis for informing future conservation actions.
Field surveys were conducted (October 2018–January 2019) in reaches of the Kosi, Ramganga, Khoh, and Song rivers, supported by semi‐structured interviews (N = 379) conducted with members of local communities to collect qualitative data on views and perceptions of otter species. In addition, community‐based otter awareness camps were organized for local youths (N = 105), adults (N = 115), and schoolchildren (N = 256 covering 10 schools).
Habitat suitability maps were created using remote‐sensing data, survey findings, and a geographic information system to provide information about priority reaches of river to be targeted for future conservation efforts.
This study provides critical interdisciplinary baseline information to guide decision‐makers towards developing a targeted, otter‐specific conservation programme for this important Himalayan biodiversity hotspot.
The otter conservation education programmes conducted during this study resulted in a proposal to set up a community‐based conservation initiative to monitor and report otter sightings from the area, potentially representing a way forward for achieving simultaneous otter conservation and associated ecosystem benefits for local communities.
Identify potential clinical significance of long noncoding RNA forkhead box P4 antisense RNA 1 in patients with early stage pancreatic ductal adenocarcinoma
Authors: Liu Xiao‐Guang , Xu Hao , Chen Ming , Tan Xiao‐Yu , Chen Xiao‐Feng , Yang Yong‐Guang , Lin Man‐Zhou , Liu Guo‐Hua , Liang Xiao‐Lu , Qian Yi‐Bin , Yuan Guo‐Jia , Chen Min‐Qiang , Li Wen‐Tao , Miao Hui‐Lai , Li Ming‐Yi , Liao Xi‐Wen , Dai Wei , Chen Nian‐Ping 
Published: January 2020

AbstractPrevious studies have shown that forkhead box P4 antisense RNA 1 (FOXP4‐AS1) is dysregulated in tumor tissues and can serve as a prognostic indicator for multiple cancers. However, the clinical significance of FOXP4‐AS1 in pancreatic ductal adenocarcinoma (PDAC) remains unclear. The goal of this study is to recognize the possible clinical significance of long noncoding RNA FOXP4‐AS1 in patients with early stage PDAC. A total of 112 patients from The Cancer Genome Atlas (TCGA) PDAC cohort, receiving RNA sequencing, were involved in the study. Survival analysis, functional mechanism, and potential small molecule drugs of target therapy of FOXP4‐AS1 were performed in this study. Survival analysis in TCGA PDAC cohort suggested that patients with high FOXP4‐AS1 expression had significantly augmented possibility of death than in PDAC patients with lower FOXP4‐AS1 expression (adjusted P = .008; adjusted HR = 2.143, 95% CI = 1.221‐3.760). In this study, a genome‐wide RNA sequencing dataset was used to identify 927 genes co‐expressing with FOXP4‐AS1 in PDAC tumor tissues. A total of 676 differentially expressed genes were identified between different FOXP4‐AS1 expression groups. Functional enrichment analysis of these genes and gene set enrichment analysis for PDAC genome‐wide RNA sequencing dataset was done. We have found that FOXP4‐AS1 may function in PDAC by participating in biological processes and pathways including oxidative phosphorylation, tricarboxylic acid cycle, classical tumor‐related pathways such as NF‐kappaB as well as Janus kinase/signal transducers in addition to activators of transcription, cell proliferation, and adhesion. In addition, we also screened two potential targeted therapeutic small molecule drugs (dimenhydrinate and metanephrine) for FOXP4‐AS1 in PDAC. In conclusion, our present study demonstrated that higher expression of FOXP4‐AS1 in PDAC tumor tissues were related with an inferior medical outcome. Through multiple genome‐wide approaches, we identified the potential molecular mechanisms of FOXP4‐AS1 in PDAC and two targeted therapeutic drugs for it.
Composition of cometary particles collected during two periods of the Rosetta mission: multivariate evaluation of mass spectral data
Authors: Varmuza Kurt , Filzmoser Peter , Fray Nicolas , Cottin Hervé , Merouane Sihane , Stenzel Oliver , Paquette John , Kissel Jochen , Briois Christelle , Baklouti Donia , Bardyn Anaïs , Siljeström Sandra , Silén Johan , Hilchenbach Martin 
Published: January 2020

AbstractThe instrument COSIMA (COmetary Secondary Ion Mass Analyzer) onboard of the European Space Agency mission Rosetta collected and analyzed dust particles in the neighborhood of comet 67P/Churyumov‐Gerasimenko. The chemical composition of the particle surfaces was characterized by time‐of‐flight secondary ion mass spectrometry. A set of 2213 spectra has been selected, and relative abundances for CH‐containing positive ions as well as positive elemental ions define a set of multivariate data with nine variables. Evaluation by complementary chemometric techniques shows different compositions of sample groups collected during two periods of the mission. The first period was August to November 2014 (far from the Sun); the second period was January 2015 to February 2016 (nearer to the Sun). The applied data evaluation methods consider the compositional nature of the mass spectral data and comprise robust principal component analysis as well as classification with discriminant partial least squares regression, k‐nearest neighbor search, and random forest decision trees. The results indicate a high importance of the relative abundances of the secondary ions C+ and Fe+ for the group separation and demonstrate an enhanced content of carbon‐containing substances in samples collected in the period with smaller distances to the Sun.
Row spacing and seeding rate effect on soybean seed yield in North Dakota
Authors: Schmitz Peder K. , Stanley Jordan D. , Kandel Hans 
Published: January 2020

AbstractNorth Dakota soybean [Glycine max (L.) Merr.] seeding rate and row spacing varies across the state due to climate factors. Eight soybean seeding rates (starting at 80,000 and increasing by 20,000 live seeds ac−1 increments) and row spacing (12 and 24 inches) were evaluated in 15 environments in 2017–2018 to quantify established plant densities, seed yield, and plant loss occurring during the season. Planting at a 12‐inch row spacing yielded 2.7 bu ac−1 greater than 24‐inch row spacing and provided $33 ac−1 greater net profit on average. Following plant establishment, 6.6% in‐season plant loss occurred on average. Using 180,000 to 200,000 live seed ac−1 had higher yields than seeding rates of 120,000 or less. Maximum net partial profit based on seeding rate was 80,800, 105,300, and 167,500 live seed ac−1 for seed costs of $57.80, $50.80, and $33, respectively, for 140,000 seeds. North Dakota's current recommendation of 150,000 established plants ac−1 is in the range to optimize yield but will likely not optimize profit based on seed costs and current market values. North Dakota farmers are recommended to use 12‐inch row spacing instead of 24 inches.