bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Consumer Awareness and Perceptions of Canastra Minas Artisanal Cheese: Text Highlighting as a Useful Approach
Authors: Rodrigues Jéssica F. , Siman Ingrid B. , Oliveira Lorena E. A. , Barcelos Alessandra F. , Bresciani Laura L. V. , Pimentel Tatiana C. , Silva Ramon , Freitas Monica Q. , Filho Elson Rogério T. , Esmerino Erick A. , Cruz Adriano G. , Amorim Katiúcia A. 
Published: February 2025

ABSTRACTThis study used text highlighting (TH) and online questionnaires to assess awareness and perceptions of Canastra cheese safety and quality and their impact on purchase decisions. A total of 100 participants performed the TH method in sensory analysis booths, where they read a text about Canastra cheese and used colored pens to highlight terms they liked or disliked. After completing the task, participants responded to attitudinal questions using Likert scales. An online questionnaire was distributed to another 100 Canastra cheese consumers to assess their perceptions of food safety and product quality. The results revealed a positive perception with high participant engagement, though consumer awareness could be improved. Women gave higher credibility on certification and legislation statements. Safety perception significantly influenced purchase intention, with state certification seals having the most significant impact. Canastra cheese has the potential to establish itself as a high‐quality and safe cheese. However, increasing consumer awareness, enhancing legislation, and implementing effective communication strategies are essential to promote and recognize it and similar artisanal products.
Economic and Social Impacts of Olive Quick Decline Syndrome: Analysing Data From the Italian Farm Accountancy Network
Authors: Calderoni Federica , Petrontino Alessandro , Frem Michel , Fucilli Vincenzo , Bozzo Francesco 
Published: February 2025

ABSTRACTThe rapid spread of Xylella fastidiosa subsp. pauca (Xfp) in the Salento area (Apulia region, southern Italy) has caused extensive socio‐economic damage to the olive oil supply chain. This research evaluates the impact of the ‘Xfp treatment’ on selected economic and social variables using a counterfactual approach. We applied propensity score matching and the difference‐in‐difference estimator to a sample of Italian Farm Accountancy Data Network panel olive‐growing farms. The study compared the outcomes of farms affected by the Xfp invasion before (2008–2012) and after (2017–2021), with a control group unaffected by Xfp. The results showed that the socio‐economic performance of Salento's olive‐growing farms is lower than unaffected farms outside the region but comparable to similarly affected farms. Regarding the economic impact of Xfp, the Gross Operating Margin had an Average Treatment Effect on the Treated of around −€837 per hectare, indicating a reduction in profitability, amounting to a total loss of €132 million across the infected area. Social indicators also showed the effects of Xfp, evident in the reduction of total working hours and work units employed on Salento olive farms. The decrease was −7 h/ha, resulting in a total loss of 1,050,000 h across the entire infected area in Apulia (approximately 150,000 ha). These findings have policy implications, because they can assist policymakers in establishing a compensation budget for Apulian olive growers affected by Xfp. Identifying fair compensation is crucial for providing financial and technical support to help farmers convert their crops or adopt alternative agricultural practices.
Revisiting the black shale depositional enigma: Transport processes and contrasting sediment sources in a heterolithic basin fill – Bowland Basin, England
Authors: Li Sen , Wignall Paul B. , Peakall Jeff , Cui Jingwei , Sun Yadong 
Published: February 2025

ABSTRACTFactors that control the accumulation of organic‐rich shales are keenly debated and include basin redox variations, sediment provenance and diverse depositional processes. The relative importance of hemipelagic settling versus sediment gravity flows has been especially contentious in recent years. This study examines the Bowland Shale, a thick succession of organic‐rich mudrock with subsidiary facies, from the late Mississippian Bowland Basin of northern England that records a broad range of depositional processes. Interbedded amongst the mudrocks are several elongate, calciturbidite fans ca 10 km in length, sourced from a small carbonate platform to the south‐east of the basin, whilst a turbidite body of siliciclastic sand entered the basin from the east. An intrabasinal high in the north‐west of the basin deflected the progradation of the turbidite sandstones and was likely also responsible for the reflection of the carbonate‐carrying sediment gravity flows generating combined flow structures in the calciturbidite fans. Abundant, fine calcareous detritus was also sourced from the south‐east, forming an apron of calcareous mudstone delivered by low‐strength debris flows. Interbedded amongst these diverse facies types, the Bowland Shale primarily consists of hemipelagic, organic‐rich shale with a fabric consisting of compacted clay lenses (0.05–0.4 mm in width), hemipelagic components (including larval shells of bivalves, goniatites and syngenetic framboids) and organic filaments (marine snow). The lenses are interpreted to be faecal pellets formed above the redoxcline before settling to the seabed. An alternative idea, that has gained much traction in mudrock studies, is that the clay lenses are transported intraclasts and that black shales are substantially the product of deposition from traction currents sourced from adjacent basin margins. This idea is problematic because it fails to address why basinal shales have a euxinic geochemical signature rather than recording the well‐oxygenated conditions of the purported source area.
Increasing use of CAR‐T therapy occurs in conjunction with decreasing stem cell transplants with stable resource usage over a 6‐year period: Resource utilization implications
Authors: Chandrasekar Aswath P. , DiGuardo Margret A. , Winters Jeffrey L. , Greiner Carl W. , Dingli David , Alkhateeb Hassan B. , Jacob Eapen K. 
Published: February 2025

AbstractBackgroundSince FDA approval in 2017, CAR‐T therapy has seen rapid clinical adoption. Shifting clinical trends have emerged with increasing utilization of CAR‐T therapies and a downward trend in HSCTs. Given the overlapping resources required for the manufacture and storage of these products, we sought to examine trends over a 6‐year period.MethodsThe apheresis patient database and Lab database were reviewed to compile a list of patients that underwent either CAR‐T or HSCT (autologous) collections, and/or received CAR‐T or autologous HSCT infusions between January 1, 2018 and December 12, 2023. This was further examined by year and disease group.ResultsThe total number of patients collecting for CAR‐T increased from 52 in 2018 to 150 in 2023 (slope = 21.97; p = .0013), accompanied by a decrease in the number of patients collecting for HSCT, from 425 in 2018 to 341 in 2023 (slope = −21.2; p = .0177). Neither total number (calculated as number of HSCT + CAR‐T) of patients collected (mean 476 + 20.4 per year), nor collection procedures (mean 972 ± 75.8 per year) changed significantly over the 6‐year period. The total number of CAR‐T infusions increased from 24 in 2018 to 111 in 2023 (slope = 17.7; p = .004), with a decrease in auto‐HSCT from 400 to 289 (slope = −28.7; p = .008). The overall number of infusions (calculated as number of HSCT + CAR‐T) did not change significantly (slope = −10.9; p = .13) over the 6‐year period.DiscussionOur findings confirm the increasing adoption of CAR‐T therapy occurring alongside a decreasing stem‐cell transplants, with stable overall resource utilization.
Motor and functional characteristics in school-age survivors of congenital diaphragmatic hernia: a cross-sectional observational study
Authors: Mitsumatsu Takamasa , Ito Yuji , Muramatsu Yukako , Sato Yoshiaki , Ito Tadashi , Narahara Sho , Miura Ryosuke , Yamamoto Hiroyuki , Ito Miharu , Shiraki Anna , Nakata Tomohiko , Kotani Tomomi , Natsume Jun , Hayakawa Masahiro , Takahashi Yoshiyuki , Kidokoro Hiroyuki 
Published: February 2025

BackgroundChildren born with congenital diaphragmatic hernia (CDH) are at risk of poor developmental outcomes. This study aimed to clarify the motor and functional characteristics of school-age CDH survivors and identify perinatal factors associated with motor function deficits.MethodsMotor function was comprehensively assessed in CDH survivors aged 6–10 years (CDH group, n=24) and in age- and sex-matched controls (n=72). Assessments included physical activity time, grip strength, the five times sit-to-stand test, one-leg standing time, 6 min walking distance and gait ability using a three-dimensional gait analysis. In the CDH group, correlations between perinatal factors and motor function outcomes were analysed.ResultsIn the CDH group, all children had isolated CDH. Three were extracorporeal membrane oxygenation (ECMO) treated and 21 were non-ECMO treated. The CDH group exhibited shorter stature, lower weight and reduced physical activity time than the controls. They also showed significantly lower grip strength, longer five times sit-to-stand test time, shorter one-leg standing time and decreased 6 min walking distance. No significant differences were found between the two groups regarding walking speed, step length or Gait Deviation Index. Within the CDH group, a higher observed-to-expected lung area-to-head circumference ratio (o/e LHR) was positively correlated with better grip strength.ConclusionsSchool-age survivors of CDH are at risk of impaired motor function. Particularly, grip strength measurement is crucial for those born with a low o/e LHR. Implementing follow-up and intervention programmes focused on improving limb muscle strength, balance, and endurance, and promoting adequate physical activity may enhance motor function.
Targeting malaria in high-risk populations in low endemic regions in northern Namibia: a quasi-experimental controlled trial to reduce malaria in seasonal agricultural workers and cattle herders
Authors: Smith Jennifer L , Ntuku Henry , Rerolle Francois , Burke Ashley Morgan , Mwema Tabeth , Turcios Keirstinne , Uusiku Petrina , Haikali Justine Kulla , Lifasi Michael , Smith-Gueye Cara , Vajda Elodie , Jacobson Jerry O , Greenhouse Bryan , Gosling Roly , Bennett Adam , Mumbengegwi Davis R 
Published: February 2025

BackgroundAgricultural worksites are rarely targeted by malaria control programmes, yet may play a role in maintaining local transmission due to workers’ high mobility, low intervention coverage and occupational exposures.MethodsA quasi-experimental controlled intervention study was carried out in farming and cattle herding populations in northern Namibia to evaluate the impact of a targeted malaria intervention package. Eight health facility catchment areas in Zambezi and Ohangwena Regions were randomised to an intervention arm and eligible individuals within worksites in intervention areas received targeted drug administration with artemether-lumefantrine, mop-up indoor residual spraying and long-lasting insecticidal nets, combined with distribution of topical repellent in Zambezi Region. Impact on malaria outcomes and intervention coverage was evaluated over a single transmission season using pre-intervention and post-intervention cross-sectional surveys in a random subset of worksites and community incidence from passively detected cases. Entomological collections and residual efficacy assays on canvas and tarpaulin were conducted.ResultsDelivery of a single intervention round was associated with a reduction in the prevalence of malaria (OR 0.24, 95% CI 0.1 to 0.5; risk difference (RD) −6.0%, 95% CI −9.4 to –2.8). Coverage of at least one intervention increased (RD 51.6%, 95% CI 44.4 to 58.2) among the target population in intervention compared with control areas. This effect was largely driven by results in Zambezi Region, which also observed a decline in community incidence (−1.29 cases/1000 person-weeks, 95% CI −2.2 to –0.3). Residual efficacy of pirimiphos-methyl (Actellic) on tarpaulin and canvas was high at 24hours but declined to 44.6% at 4 months.ConclusionThe study shows that targeted delivery of malaria interventions to cattle herders and agricultural workers at worksites has potential to impact local transmission. Findings highlight the need for further research on the role of key populations inPlasmodium falciparumtransmission in Namibia.Trial registration numberNCT04094727.
Effective coverage for reproductive, maternal, neonatal and newborn health: an analysis of geographical and socioeconomic inequalities in 39 low- and middle-income countries
Authors: Marthias Tiara , Anindya Kanya , Saputri Nurmala Selly , Putri Likke Prawidya , Atun Rifat , Lee John Tayu 
Published: February 2025

BackgroundInadequate access to quality maternal and child health services leads to poor health outcomes for millions of women, particularly in low- and middle-income countries (LMICs). This study aims to explore the effective coverage of reproductive, maternal, neonatal and newborn health (RMNCH) services and examines socioeconomic and rural and urban disparities in 39 LMICs.MethodsUsing Demographic and Health Surveys (DHS) data, the research assesses RMNCH service quality by applying an effective coverage framework, which measures service contact, crude coverage, quality-adjusted coverage and user adherence-adjusted coverage. We applied weighted analyses to investigate the rural–urban differences in service coverage based on countries’ Human Development Index (HDI) levels as well as crude coverage and socioeconomic levels.FindingsUrban areas generally exhibit better effective coverage across all RMNCH services compared with rural areas, with significant disparities in antenatal, childbirth and postnatal care. For instance, 85% (95% CI=85–86%) of urban women received skilled birth attendance compared with 64% (95% CI=64–65%) in rural areas. High-HDI countries show smaller rural–urban gaps in service coverage than low-HDI countries. Socioeconomic inequalities are more pronounced in rural areas, particularly in services that require higher quality and adherence to standards. Socioeconomic disparities are significant in LMICs with lower HDI and are more evident in harder-to-achieve quality indicators, such as user adherence to recommended practices or treatment. For example, in medium-HDI countries, the relative inequality index (RII) for antenatal care user adherence coverage is 3.6 (95% CI=3.4–3.8) in rural areas compared with 1.9 (95% CI=1.8–2.1) in urban areas.InterpretationThe research underscores the need for targeted interventions and policies to address these disparities. The evidence supports the need for a shift from focusing solely on access to care to improve the quality of care to address rural–urban and socioeconomic inequalities in RMNCH outcomes.
Acceptance and commitment therapy for mild traumatic brain injury (ACTion-mTBI): a quasiexperimental feasibility study
Authors: Faulkner Josh , Prouty Devin , Devlin Lucy , Appleton Damien , Roche Maree , Below Karen , Moffat John , Snell Deborah , Williams Matt N , Barker-Collo Suzanne , Theadom Alice 
Published: February 2025

ObjectivesThis study aimed to determine the feasibility of recruiting, implementing and delivering an acceptance and commitment therapy (ACT) intervention for mild traumatic brain injury (mTBI) (ACTion-mTBI) within a multidisciplinary outpatient mTBI rehabilitation services. The study also aimed to conduct a preliminary investigation of group differences between ACTion-mTBI and an equivalent cognitive behavioural therapy (CBT) intervention on various outcome measures and psychological treatment targets.DesignA two-arm quasiexperimental feasibility study.SettingFive mTBI rehabilitation clinics throughout New Zealand.InterventionPsychologists working in mTBI rehabilitation clinics throughout New Zealand were trained to deliver ACTion-mTBI or CBT. Eligible participants were assigned to either of these interventions based on the psychologist available at the clinic they were referred to. ACTion-mTBI is a five sessions intervention that incorporates all six components of the ACT model. The CBT intervention is an equivalent intervention and incorporating all four components of the CBT model. Both interventions are adapted for an mTBI context.Primary outcome measuresThe primary outcomes were related to the feasibility of ACTion-mTBI. This included recruitment, retention and treatment adherence of participants, study procedure and fidelity of treatment delivery.Secondary outcome measuresTo explore group differences between ACTion-mTBI and CBT on functional disability, postconcussion symptoms, mental health, valued living and psychological flexibility.ResultsThe intervention proved feasible to implement with community-based mTBI rehabilitation services. Attrition rates were comparable between the two psychological interventions and fidelity to the treatments was high. At post-treatment, when covarying pretreatment scores, ACTion-mTBI had a significantly greater improvement in functional disability than CBT (moderate effect). ACTion-mTBI also had a significantly greater reduction in postconcussion symptoms, anxiety and stress. Promisingly, significant improvements in psychological flexibility was also found post-treatment. There were no group differences on depressive symptoms and valued living.ConclusionWe conclude that a full clinical trial of ACTion-mTBI for individuals with mTBI is feasible and warranted.Trial registration numberACTRN1262100059482.
Therapy response prediction of focal cortex stimulation based on clinical parameters: a multicentre, non-interventional study protocol
Authors: Kalousios Sotirios , Hesser Jürgen , Dümpelmann Matthias , Baumgartner Christoph , Hamer Hajo M , Hirsch Martin , Imbach Lukas , Kaufmann Elisabeth , Kegele Josua , Knake Susanne , Leonhardt Georg , Mayer Thomas , Mertens Ann , Pataraia Ekaterina , von Podewils Felix , Quesada Carlos M , Steinhoff Bernhard J , Surges Rainer , Voges Berthold R , Wagner Jan , Weber Yvonne G , Wehner Tim , Winter Yaroslav , Schulze-Bonhage Andreas 
Published: February 2025

IntroductionA novel focal cortex stimulation (FCS) device has recently received approval in Europe for patients with focal drug-resistant epilepsy (DRE). After 6 months of stimulation, 17 of 32 patients achieved ≥50% reduction in seizure frequency compared with their prestimulation baseline (responders). Currently, there is no established method for predicting FCS treatment response prior to implantation.Methods and analysisThis is an ongoing combined retrospective-prospective non-interventional multicentre study. Clinical data of up to 100 patients treated with FCS are collected across 20 collaborating epilepsy centres in four European countries. The key outcome parameters, seizure frequency and severity, are measured along with metrics on cognition, mood and quality of life, both pre-electrode and postelectrode implantation. The data are complemented by demographics, medical history and information on antiseizure medication and FCS treatment parameters during the stimulation period. In addition to clinical data, MRI and electroencephalography registrations are used to gain insights into spatial and electrophysiological aspects of FCS. Multivariate statistical and machine learning analyses are employed to identify key predictive biomarkers associated with patient outcomes (responders vs non-responders). The primary goal is to improve counselling for DRE patients by identifying promising candidates for FCS treatment.Ethics and disseminationThis study has received approval from the ethics committee of the University of Freiburg, Germany (23–1540 S1; 23–1183_1-S1-retro). The same approval is applicable for all participating centres in Germany as part of a multicentre study. Ghent University Hospital, Belgium, has received approval for participation in the retrospective arm from their local ethics committee(ONZ-2024-0168). The final approvals for the participating Swiss and Austrian sites are still pending. The results will be made available to the public through peer-reviewed journals and conference presentations.
Association between calcium and vitamin D supplementation and increased risk of kidney stone formation in patients with osteoporosis in Southwest China: a cross-sectional study
Authors: Shi Lingfeng , Bao Yinyin , Deng Xiang , Xu Xiaoli , Hu Jiongyu 
Published: February 2025

ObjectivesThis cross-sectional study aims to evaluate the association between calcium and vitamin D supplementation for osteoporosis treatment and the development of kidney stones while investigating the impact of urinary calcium excretion on kidney stone risk among patients receiving this supplementation treatment.DesignThe study involved collecting data from 204 Chinese Han patients aged 50–89 with osteoporosis in the southwest region of China. These patients had been on daily doses of 600 mg of calcium carbonate and 0.5 µg alfacalcidol for at least 1 year. The study employed univariate analysis and multivariable logistic regression to identify risk factors for kidney stones, with independent t-tests used to compare differences between groups.SettingData were collected from patients in the southwest region of China, covering the period from July 2019 to December 2023.ParticipantsThe study included 204 patients with osteoporosis, all of whom had been receiving the specified calcium and vitamin D supplements for the duration of the study.ResultsThe study found that a history of recurrent kidney stones was an independent risk factor for the development of kidney stones. Patients with kidney stones who had a history of recurrent stones exhibited significantly higher levels of 24-hour urinary calcium excretion (1.00±0.62 vs 0.57±0.54, p=0.026) compared with those without such a history.ConclusionsThe results suggest that a history of recurrent kidney stones independently increases the risk of kidney stones in patients undergoing calcium and vitamin D supplementation for osteoporosis, likely due to increased urinary calcium excretion.