bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of multifunctional compositions based on Rheum rhaponticum L. extracts for the elaboration of plant protection products
Authors: Gladcaia A. A. 
Published: August 2020

Relevance.Extract-based compositions, combining various types of biological activity were created and tested, to reveal the potential of genus Rheum (Polygonaceae)plants bioactive substances. The aim of the work was to determine the composition of bioactive substances in R. rhaponticum L. plants extracts and assess the possibility of their use as a means of protecting vegetable plants from powdery mildew.Materials and methods. The methods of cultivation and research of R.rhaponticum plant materials was carried out at the Institute of Genetics, Physiology and Plant Protection, Chisinau, Republic of Moldova (2012-2019). The subject of our study the bioactive substances of rhubarb roots and leaves were used. Results.The localization zones of anthracene derivatives were identified: in the main parenchyma of the secondary cortex and the parenchyma of the core rays of the rhubarb root. The amount of flavonoids and phenols in the root extract is 2 times more than in the leaf extract. To study the fungicidal and stimulating properties of rhubarb root extract in the control of powdery mildew, we conducted studies in a greenhouse on vegetable plants using artificial infection of seedlings. It was found that the chlorophyll transmittance index of leaves treated with rhubarb root extract increases until the concentration of the extract (R) reaches 1.5% (157.3 rel. units)(In the control – 119.2 rel. units). With increasing concentration of the extract to 2%, the chlorophyll index falls 1.2 times lower than the control values. The highest immunostimulating and fungicidal activity, intensifying with the addition of rhubarb leaf extract, was shown by rhubarb root extract. Its biological effectiveness was high at any intervals between treatment and infection (4 and 72 hours), and was directly proportional to concentration. Adding rhubarb leaf extract to the rhubarb root extract enhances the activity of the composition, and the risk of developing pesticide resistance among plant pathogens decreased.
THE INHIBITORY ACTIVITY OF KELAKAI LEAF EXTRACT AGAINST THE GROWTH OF Porphyromonas gingivalis ATCC® 33277™
Authors: Khotimah Destri Khusnul , Krishnawan Firdaus I Wayan Arya , Apriasari Maharani Laillyza 
Published: August 2020

ABSTRACTBackground: Chronic periodontitis is an infectious disease that causes damage on periodontal ligament and alveolar bone. The severity of periodontitis is caused by several types of bacterial species which one of them is Porphyromonas gingivalis bacteria with a prevalence of 85% in oral cavity. The extract of kelakai leaf contained antibacterial in the form of flavonoid, alkaloid, tannin, and steroid. Flavonoid consists of some chemical compounds which is one of them is quercetin. The level of quercetin in kelakai leaf is 503.56 mgQE/g. From some secondary metabolites, kelakai leaf has inhibitory power toward gram negative bacterial, Porphyromonas gingivalis. Objective: This research was intended to know the activity of inhibitory power of kelakai leaf toward Porphyromonas gingivalis bacteria. Method: This research was an experimental research consisted of 5 experimental groups that were group of kelakai leaf extract on the concentrations of 100 mh/ml, 75 mg/ml, 50mg/ml, and 25 mg/ml and the control group (0.2% chlorhexidine). Each treatment was done in 4 repetitions. The test of inhibitory power used diffusion method by measuring the inhibitory zone around the growth of Porphyromonas gingivalis on Mueller Hinton Agar media. The data were analyzed by using One Way Anova 95% and then continued with LSD. Results: Based on the LSD test, it was known that the extract of Kelakai leaf had inhibitor power activity toward Porphyromonas gingivalis. The highest inhibitory zone was on the concentration of 100 mg/ml with inhibitory zone of 14.61 mm. Conclusion: The extract of kelakai leaf had inhibitory power activity toward Porphyromonas gingivalis bacteria in vitro. Keywords: 0.2% chlorhexidine, Diffusion method, Inhibitory power, Stenochlaena palustris extract, Porphyromonas gingivalis.
TREATMENT OF CLASS I MALOCCLUSION WITH MILD CROWDING AND MIDLINE SHIFT
Authors: Triwidianto Edwin , Narmada Ida Bagus 
Published: August 2020

ABSTRACT Background: The main goal of orthodontic treatment is to obtain a normal relationship of the teeth with facial structures and it is generally accepted that orthodontic treatment will have effects on facial proportion. Nowadays, facial appearance has a big influence on someone's appearance. Aesthetic facial appearance will produce a proportional, harmonious, and youthful facial profile. Case: this case report aims to describe that non extraction orthodontic treatment in class I malocclusion with mild crowding and mildline shift is a treatment with considerable success. Case management: A 19 years old female came with a chief complaint of crowding in upper and lower jaw. Intraoral examination revealed bilateral Class I molar and canine relationship. Patient had crowding in upper and lower jaw, and midline shift in lower jaw. Extra oral findings included a flat profile with competent lips. Cephalometric analysis showed skeletal class I with orthognati maxilla and mandible. Patient was bonded with 0.022-inch MBT brackets orthodontic appliance without extraction. After 20 months of treatment, an ideal arch coordination was achieved, the patient felt confident and satisfied with the treatment outcome. Conclusion: Decision to extract a tooth has to be made, not only by considering the amount of crowding, but also the eventual influence of orthodontic tooth displacement on the soft tissue surface of the face. Keywords: Crowding, Midline shift, Non – extraction.
THE IMPORTANT ROLE OF ORAL MEDICINE SPECIALIST IN MANAGEMENT OF STEVENS-JOHNSON SYNDROME PATIENT
Authors: Fitriasari Nuri , Nurtito Eko Rotary , Nur’aeny Nanan , Wahyuni Indah Suasani 
Published: August 2020

ABSTRACTIntroduction: Stevens-Johnson Syndrome (SJS) is an acute hypersensitivity reaction that manifests on the skin, oral mucosa, ocular, gastrointestinal, genital and anal area. It is also potentially life-threatening in concern of dehydration and infection. Oral mucosal lesions due to SJS resulted in a significant decrease of patient’s quality of life. When the oral mucosa involved, the intake of nutrients and fluids is disrupted contributing to electrolyte imbalance that aggravates dehydration. Moreover, oral mucosal lesions have become an entry point for infection. Purpose: This case report describes the important role of oral medicine specialists in the management of oral mucosal lesions in SJS patient. Review: A 26-year-old female patient was referred from the Department of Dermatology and Venereology with a diagnosis of SJS et causa suspected paracetamol and/or amoxycillin. The complaints comprised of pain on the lips and oral cavity, difficulty in mouth opening, and pain when swallowing. The management for oral lesions included: history taking, external and intra oral examinations, dexamethasone mouthwash, nystatin oral suspension, and sodium chloride (NaCl) 0.9% solution. The patient showed improvement in oral mucosal lesions within 3 weeks of treatment that was provided by oral medicine specialist and medical team collaboration. Conclusion: Based on this case report, the role of oral medicine specialist is very important as part of the management team for SJS patient. Oral medicine specialist can reduce morbidity that results from oral mucosal involvement. Collaboration with oral medicine specialist since the beginning of treatment is the key to success in SJS management. Keywords: Oral medicine specialist, Oral mucosal lesion, Stevens-Johnson Syndrome.
Musik Tradisional Sampek Kalimantan Timur
Authors: Mulyati Sri Ayu 
Published: August 2020

AbstractThis study aimed to describe organologi and basic techniques of playing traditional musical instruments sampek in East Kalimantan. This study used a qualitative approach to data collection techniques used were observation and interviews. Data analysis was done by the process of categorization, preparation, systematization, and then draw conclusions. Test validation of the data used is source triangulation techniques, techniques da time. Based on this research, it is known that organologi sampek consists of seven parts, the basic techniques of playing sampek have the four stages, and how to play sampek has six stages.Keywords: traditional music, sampek, east kalimantan
Determinants of Traders’ Income at the Revitalized Vs Non-Revitalized Traditional Wet Market
Authors: Pratami Anindya Rahayu , Priyono Rakhmat , Arintoko Arintoko 
Published: August 2020

The modern market has made the wet market have to change its appearance to be able to provide competitiveness with the modern market. Therefore, in this study comparing wet markets that have been revitalized (Manis Market) and not revitalized (Pon Market) in Purwokerto. In this research, to analyze the influence of several factors such as capital, working hours and length of business on the income of traders and to analyze differences in the average income of traders in Manis Market and Pon Market. The data used in this research are primary data taken from 84 respondents from Manis Market and 55 respondents from Pon Market. The results of multiple linear regression analysis show that capital has a significant influence on the income of traders while other factors such as working hours and length of business do not significantly influence the income of traders in the Manis Market. Then the capital and duration of the business have a significant influence on the income of traders while other factors such as working hours do not significantly influence the income of traders in Pon Market. Result of Independent Sample t-test also shows that there are significant differences in the average income of traders between Manis Market and Pon Market. Thus, revitalization is still a factor that can enhance the competitiveness of traditional markets.Keywords: income, capital, working hours, length of business, and revitalization
The Piano: A Psychoanalytic Approach to Movie as A Media of Reflective Teaching
Authors: Wardani Erna 
Published: August 2020

Freud’s psychoanalytic approach has been one of the most controversial approaches to many fields of interest. Relating to education and educational psychology, this approach plays a significant role in modifying and enhancing one’s behavioral relationship among the educational elements like educators, parents, and students. Therefore, in many things, this approach has contributed a lot of inspiration in the development of education. In literary works, there seems to be a mutual fascination between psychoanalysis and literature whereas theory and approach, psychoanalysis explains literature and literature itself exploits psychoanalysis for creative purposes and works. Here, as a creative work, movie is considered literature because it can be interpreted and analyzed just like other written works of literature. As a learning instrument, movie evokes an affective domain that leads to changes in learning behavior and attitudes. Experiencing certain-themed movies can trigger particular reflective memories and reference toward events occurring on a daily basis and it can further strengthen the foundation for learning complex concepts like psychoanalysis.
EFEK PAPARAN KADMIUM (Cd) TERHADAP FUNGSI GINJAL PEKERJA BENGKEL LAS
Authors: Hernayanti Hernayanti , Santoso Slamet , Lestari Sri , Prayoga Lucky , Kamsinah Kamsinah , Rochmatino Rochmatino 
Published: August 2020

ABSTRAK
Kadmium merupakan salah satu logam berat yang bersifat nefroksik dan membahayakan kesehatan manusia, terutama pekerja bengkel las. Kadmium masuk ke dalam tubuh berikatan dengan metalotionin membentuk ikatan Cd+Mt akan terdeposit di organ ginjal dan menginduksi terbentuknya radikal bebas sehingga mengakibatkan peroksidasi lipid yang dapat merusak organ ginjal, ditandai dengan peningkatan kreatinin dan β2 mikroglobulin. Tujuan penelitian adalah untuk mengetahui efek paparan Cd terhadap fungsi ginjal pekerja bengkel las ditinjau dari parameter kreatinin dan β2 mikroglobulin (β2-M). Rancangan penelitian menggunakan rancangan kasus kontrol. Subyek penelitian terdiri dari 30 orang pekerja bengkel las di Purwokerto dengan masa kerja lebih dari 3 tahun sebagai subyek kasus dan subyek kontrol dari desa Pamijen Baturaden yang mewakili bukan pekerja bengkel las. Data dianalisis menggunakan uji t independent. Hasil penelitian menunjukkan kadar Cd darah, kreatinin darah dan β2 mikroglobulin pada subyek kasus berbeda nyata dibandingkan dengan subyek kontrol. Kadar Cd, kreatinin darah dan β2 mikroglobulin subyek kasus lebih tinggi dibandingkan subyek kontrol. Kesimpulan penelitian paparan Cd berpengaruh terhadap penurunan fungsi ginjal pekerja bengkel las yang ditandai dengan peningkatan kadar Cd darah, kreatinin dan β2-M.
HUBUNGAN TINGKAT PENGETAHUAN TENTANG KEPUTIHAN DENGAN PENANGANAN KEPUTIHAN PADA SISWI KELAS X SMK YPE SUMPIUH KABUPATEN BANYUMAS TAHUN 2018
Authors: Fitriyani Tanti , Oktanasari Wiji 
Published: August 2020

ABSTRACT
One of the clinical complaint from adolescent reproduction is leucorrhea. Leucorrhea is vagina’s liquid expenditure that not shaped blood. It is sometimes caused infection that always wet and make irritation, feel itchy and disturbance to the sufferer.
The purpose of this research is to know about relation between knowledge of leucorrhea and handling of leucorrhea in student of SMK YPE Sumpiuh 2018 grade X, Banyumas regency.
This research use analytic survey method with cross sectional approach. The subject of this research is students of SMK YPE Sumpiuh grade X. The number of students are 71 person. The analysis method of the statistic that used is chi square.
The result from this research is 42 student (59,2%) have good level of knowledge about leucorrhea. And 39 student (54,9%) can handles leucorrhea correctly.
The Conclusion of his research is there any relationship between knowledge of leucorrhea and handling of leucorrhea in class of student SMK YPE Sumpiuh grade X (c2hitung=5,722> c2tabel=3,481).
Keyword : level of knowledge, leucorrhea handling.
Bibliography : 29 ( 2005-2016)
LncRNA and transcriptomic analysis of fetal membrane reveal potential targets involved in oligohydramnios
Authors: Ou Yu-hua , Liu Yu-kun , Zhu Li-qiong , Chen Man-qi , Yi Xiao-chun , Chen Hui , Zhang Jian-ping 
Published: August 2020

Abstract
Background: The multiple causes of oligohydramnios make it challenging to study. Long noncoding RNAs (lncRNAs) are sets of RNAs that have been proven to function in multiple biological processes. The purpose of this study is to study expression level and possible role of lncRNAs in oligohydramnios.Methods: In this study, total RNA was isolated from fetal membranes resected from oligohydramnios pregnant women (OP) and normal amount of amniotic fluid pregnant women (Normal). LncRNA microarray was used to analyze the differentially expressed lncRNAs and mRNAs. Kyoto Encyclopedia of Genes and Genomes (KEGG) was used to analyze the main enrichment pathways of differentially expressed mRNAs. Real-time quantitative PCR (qPCR) was used to validate the lncRNA expression level.Results: LncRNA microarray analysis revealed that a total of 801 lncRNAs and 367 mRNAs were differentially expressed in OP; in these results, 638 lncRNAs and 189 mRNAs were upregulated, and 163 lncRNAs and 178 mRNAs were downregulated. Of the lncRNAs, 566 were intergenic lncRNAs, 351 were intronic antisense lncRNAs, and 300 were natural antisense lncRNAs. The differentially expressed lncRNAs were primarily located in chromosomes 2, 1, and 11. KEGG enrichment pathways revealed that the differentially expressed mRNAs were enriched in focal adhesion as well as in the signaling pathways of Ras, tumor necrosis factor (TNF), estrogen, and chemokine. The qPCR results confirmed that LINC00515 and RP11-388P9.2 were upregulated in OP. Furthermore, the constructed lncRNA–miRNA–mRNA regulatory network revealed tenascin R (TNR), cystic fibrosis transmembrane conductance regulator (CFTR), ATP-binding cassette sub-family A member 12 (ABCA12), and collagen 9A2 (COL9A2) as the candidate targets of LINC00515 and RP11-388P9.2.Conclusions: In summary, we revealed the profiles of lncRNA and mRNA in OP. These results might offer potential targets for biological prevention for pregnant women with oligohydramnios detected before delivery and provided a reliable basis for clinical biological treatment in OP.
Comparisons of cardiovascular dysautonomia and cognitive impairment between de novo Parkinson’s disease and de novo dementia with Lewy bodies
Authors: Oka Hisayoshi , Umehara Tadashi , Nakahara Atsuo , Matsuno Hiromasa 
Published: August 2020

Abstract
Background Cognitive impairment may be correlated with cardiovascular dysautonomia, including blood pressure (BP) dysregulation, in Parkinson’s disease (PD), but the association between these factors in dementia with Lewy bodies (DLB) is uncertain. This study aimed to clarify whether cardiovascular dysautonomia had an influence on cognitive function in Lewy body disease or not.Methods 99 patients with de novo PD (n=75) and DLB (n=24) were evaluated using the Mini-Mental State Examination (MMSE) and Frontal Assessment Battery (FAB). Cardiac 123I-metaiodobenzylguanidine (MIBG) scintigraphy, orthostatic hypotension (OH), supine hypertension (SH), postprandial hypotension (PPH), nocturnal BP fall in 24-hour ambulatory blood pressure monitoring (ABPM) and constipation were estimated. Associations of these factors with cognitive and executive dysfunction were examined. Results In DLB, MIBG uptake was reduced and OH, PPH and SH were severely disturbed, compared to PD. The nocturnal BP fall in ABPM was lower in DLB, and the failure of nocturnal BP fall in PD was associated with MMSE, after adjustment for other clinical features. FAB was significantly associated nocturnal BP fall, age and SH in PD, but no significant correlations among factors were found for DLB. Conclusion The significant association between nocturnal BP dysregulation and cognitive or executive decline in PD might be due to impaired microvascular circulation or invasion of α-synuclein in the CNS. The lack of a correlation of BP insufficiency with cognitive impairment in DLB suggests initial involvement of Lewy body pathology in the neocortex, regardless of Lewy body invasion of the autonomic nervous system.
Evaluating the Care Provision of a Community-Based Serious-Illness Care Program Via Chart Measures
Authors: Kistler Christine , Dongen Matthew Van , Ernecoff Natalie , Daaleman Timothy , Hanson Laura 
Published: August 2020

Abstract
Background: Although quality-of-care domains for home-based primary and palliative programs have been proposed, they have had limited testing in practice. Our aim was to evaluate the care provision in a community-based serious-illness care program, a combined home-based primary and palliative care model.Methods: Retrospective chart review of patients in an academic community-based serious-illness care program in central North Carolina from August 2014 to March 2016 (n=159). Chart review included demographics, health status, and operationalized measures of seven quality-of-care domains: medical assessment, care coordination, safety, quality of life, provider competency, goal attainment, and access.Results: Patients were mostly women (56%) with an average age of 70 years. Patients were multi-morbid (53% ≥3 comorbidities), functionally impaired (45% had impairment in ≥2 activities of daily living) and 32% had dementia. During the study period, 31% of patients died. Chart review found high rates assessment of functional status (97%), falls (98%), and medication safety (96%). Rates of pain assessment (70%), advance directive discussions (65%), influenza vaccination (59%), and depression assessment (54% of those with a diagnosis of depression) were lower. Cognitive barriers, spiritual needs, and behavioral issues were assessed infrequently (35%, 22%, 21%, respectively).Conclusion: This study is one of the first to operationalize and examine quality-of-care measures for a community-based serious-illness care program, an emerging model for vulnerable adults. Our operationalization should not constitute validation of these measures and revealed areas for improvement; however, the community-based serious-illness care program performed well in several key quality-of-care domains. Future work is needed to validate these measures.
Interaction Kinetics of Peptide Lipids-Mediated Gene Delivery
Authors: Zhao Yinan , Zhao Tianyi , Du Yanyan , Cao Yingnan , Xuan Yang , Chen Huiying , Zhi Defu , Guo Shutao , Zhong Fangli , Zhang Shubiao 
Published: August 2020

Abstract
Background: During the course of gene transfection, the interaction kinetics between liposomes and DNA is speculated to play very important role for blood stability, cellular uptake, DNA release and finally transfection efficiency. Results: As cationic peptide liposomes exhibited great gene transfer activities both in vitro and in vivo, two peptide lipids, containing a tri-ornithine head (LOrn3) and a mono-ornithine head (LOrn1), were chosen to further clarify the process of liposome-mediated gene delivery in this study. The results show that the electrostatically-driven binding between DNA and liposomes reached nearly 100% at equilibrium, and high affinity of LOrn3 to DNA led to fast binding rate between them. The binding process between LOrn3 and DNA conformed to the kinetics equation: y = 1.663631 × exp(-0.003427x) + 6.278163. Compared to liposome LOrn1, the liposome LOrn3/DNA lipoplex exhibited a faster and more uniform uptake in HeLa cells, as LOrn3 with a tri-ornithine peptide headgroup had a stronger interaction with the negatively charged cell membrane than LOrn1. The efficient endosomal escape of DNA from LOrn3 lipoplex was facilitated by the acidity in late endosomes, resulting in broken carbamate bonds, as well as the“proton sponge effect”of the lipid. Conclusions: The interaction kinetics is a key factor for DNA transfection efficiency. This work provided insights into peptide lipid-mediated DNA delivery that could guide the development of the next generation of delivery systems for gene therapeutics.
Evaluation of lateral flow immunochromatographic assay for diagnostic accuracy of cryptococcosis
Authors: Xie Li-Min , Lin Geng-ling , Dong Hao-Neng , Liao Ying-Xia , Liu Ye-Ling , Qin Jian-Feng , Guo Xu-Guang 
Published: August 2020

Abstract
Background: Cryptococcus is a conditional pathogenic fungus causing cryptococcosis, which is one of the most serious fungal diseases faced by humans. Lateral flow immunochromatographic assay (LFA) is successfully applied to the rapid detection of cryptococcal antigens. Methods: Studies were retrieved systematically from the Embase, PubMed, Web of Science, and Cochrane Library before July 2019. The quality of the studies was assessed by Review Manager 5.0 based on the Quality Assessment of Diagnostic Accuracy Study guidelines. The extracted data from the included studies were analyzed by Meta-DiSc 1.4. Stata 12.0 software was used to detect the publication bias. Results: A total of 15 articles with 31 fourfold tables were adopted by inclusion and exclusion criteria. The merged sensitivity and specificity in serum were 0.98 and 0.98, respectively, and those in the cerebrospinal fluid were 0.99 and 0.99, respectively. Conclusions: Compared to the urine and other samples, LFA in serum and cerebrospinal fluid is favorable evidence for the diagnosis of cryptococcosis with high specificity and sensitivity.