bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magneto-optical properties of two-layer film systems based on Fe and Cr
Authors: Bezdidko Oleksandr , Yuriy Shkurdoda , Fedchenko Olena , Cheshko Iryna , Protsenko Serhiy 
Published: October 2020

The results of the investigation of two-layer Fe/Cr systems using the magneto-optical Kerr effect (MOKE) are presented in this paper. The samples were obtained by thermal evaporation in a vacuum with a thickness of individual layers from 2 nm to 50 nm. It was found that the presence of the Cr layer significantly affects the values of the coercivity and the Kerr angle. At a substrate temperature of 450 K, the value of the coercivity is almost half that of the same sample obtained at room temperature of the substrate. In addition, the influence of the order of deposition of layers, as well as the effect of a thin gold protective layer on the parameters measured by the Kerr method, is shown. These studies have shown that the MOKE can be used as an additional method for studying the composition of multilayer systems, granular alloys and spin-valve systems, using specific software methods.
Elastic properties and electronic structure of tetragonal KDP crystal under polishing pressures from first principles
Authors: Jia Huiling , Wang Feng , Wu Jinxiu , Tan Xin , Cao Yanan 
Published: October 2020

The elastic properties and electronic structure of tetragonal Potassium dihydrogen phosphate (KDP) under polishing pressures were investigated using the plane-wave pseudopotential method based on density functional theory. The results show that the calculated lattice constant, elastic constants and bandgap agreed well with the results of the experiments and the other calculations at ambient pressure. The elastic constants and the elastic moduli of KDP increase with increasing pressure, but Vickers hardness of KDP decreases. KDP crystal changes from brittleness to ductility beyond the pressure of 3 GPa. The anisotropy of KDP increases and the ratio of [Formula: see text]/[Formula: see text] increases with the increase of pressure. When the pressure reaches 4.5 GPa, the tetragonal KDP will undergo structural phase transition. As pressure increases, the bandgap between and O-2[Formula: see text] and P-3[Formula: see text] states increases. The interatomic distances were shortened under external pressure, and the interaction between K[Formula: see text] and the neighboring H2PO[Formula: see text] was enhanced, which leads to the increase of elastic mechanical properties.
Seismic expression of carbonate build-up karstification: karst modelling strategies and insights from synthetic seismic
Authors: Fournillon Arnaud , Fournier François , Vidal Olivier 
Published: October 2020

Abstract
Many ancient carbonate build-ups are impacted by meteoric diagenetic processes, including karstification. However, very little is known about the acoustic properties and seismic expression of karstified reservoirs. This paper investigates potential seismic expressions of karstified build-ups by means of synthetic seismic modelling. The overall stratigraphic architecture and physical properties of rock are derived from published examples of SE Asian carbonate build-ups. Various karst systems, corresponding to distinct stages of karstification of varying intensity, have been superimposed to the background facies-related acoustic model. Three-dimensional synthetic seismic cubes have been computed from the karst-bearing acoustic model and by testing various wavelet frequencies. The proposed approach allowed several types of palaeokarst to be reproduced, from dendritic karst and flank-margin caves to cave networks, in amplitude sections. However, geometrical seismic attributes, like coherency, cannot be accurately reproduced with modelling based on the available literature. In addition, the exploration of this synthetic seismic data shows that non-stratiform diagenetic bodies (i.e. leached carbonate wedges in a mixing zone) appear as stratiform even in very-high-resolution seismic. Thus, their detection and characterization require advanced techniques or prior knowledge, such as borehole data.
Effect of Prehospital Crushed Prasugrel Tablets in Patients With ST-Segment–Elevation Myocardial Infarction Planned for Primary Percutaneous Coronary Intervention
Authors: Vlachojannis Georgios J. , Wilschut Jeroen M. , Vogel Rosanne F. , Lemmert Miguel E. , Delewi Ronak , Diletti Roberto , van der Waarden Nancy W.P.L. , Nuis Rutger-Jan , Paradies Valeria , Alexopoulos Dimitrios , Zijlstra Felix , Montalescot Gilles , Angiolillo Dominick J. , Krucoff Mitchell W. , Van Mieghem Nicolas M. , Smits Pieter C. 
Published: October 2020

Background:

Early treatment with a potent oral platelet P2Y
12
inhibitor is recommended in patients presenting with ST-segment–elevation myocardial infarction scheduled to undergo primary percutaneous coronary intervention (pPCI). The impact on coronary reperfusion of crushed P2Y
12
inhibitor tablets, which lead to more prompt and potent platelet inhibition, is unknown.

Methods:
We conducted a randomized controlled, multicenter trial in the Netherlands, enrolling patients with ST-segment–elevation myocardial infarction scheduled to undergo pPCI. Patients were randomly allocated to receive in the ambulance, before transfer, a 60-mg loading dose of prasugrel either as crushed or integral tablets. The independent primary end points were thrombolysis in myocardial infarction (TIMI) 3 flow in the infarct-related artery at initial coronary angiography, and complete (≥70%) ST-segment resolution 1 hour after pPCI. The safety end points were TIMI major and Bleeding Academic Research Consortium ≥3 bleedings. Secondary end points included platelet reactivity and ischemic outcomes.

Results:

A total of 727 patients were assigned to either crushed or integral tablets of prasugrel loading dose. The median time from study treatment to wire-crossing during pPCI was 57 (47–70) minutes. The primary end point TIMI 3 flow in the infarct-related artery before pPCI occurred in 31.0% in the crushed group versus 32.7% in the integral group (odds ratio, 0.92 [95% CI, 0.65–1.30],
P
=0.64). Complete ST-segment resolution 1 hour after pPCI was present in 59.9% in the crushed group versus 57.3% in the integral group (odds ratio, 1.11 [95% CI, 0.78–1.58],
P
=0.55). Platelet reactivity at the beginning of pPCI, measured as P2Y
12
reactivity unit, differed significantly between groups (crushed, 192 [132–245] versus integral, 227 [184–254],
P
≤0.01). TIMI major and Bleeding Academic Research Consortium ≥3 bleeding occurred in 0% in the crushed group versus 0.8% in the integral group, and in 0.3% in the crushed group versus 1.1% in the integral group, respectively. There were no differences observed between groups regarding ischemic events at 30 days.

Conclusions:
Prehospital administration of crushed prasugrel tablets does not improve TIMI 3 flow in the infarct-related artery before pPCI or complete ST-segment resolution 1 h after pPCI in patients presenting with ST-segment–elevation myocardial infarction scheduled for pPCI.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03296540.
Thinking Beyond the Lockdown: On the Possibility of a Democratic Biopolitics
Authors: Sotiris Panagiotis 
Published: October 2020

Abstract
COVID-19 is not only a health emergency but also a strategic challenge for any politics of resistance, struggle and transformation. Understanding the social and political dynamics associated with morbidity and mortality and the many ‘ecologies of disease’ associated with the pandemic is necessary if we want to think beyond the limits of the lockdown strategy. It is here that the possibility of a democratic biopolitics emerges as part of a broader strategy for communism.
Global Governance and the Double Movement
Authors: Mendly Dorottya 
Published: October 2020

Abstract
This article reconstructs the evolution of global governance through time, in a perspective organized around Karl Polanyi’s double movement. Starting from present-day global governance, the article reaches back in time to understand the different socially and historically contingent layers that have constituted it as a discourse and a set of practices. It argues based on the notion that global governance is a hegemonic discourse of world politics, and claims that it is so because it has become inclusive enough to accommodate both the “movement” and the “countermovement” in its cognitive and material structures. In this order of knowledge, the “healthy functioning” of the global economy always precedes the existence of prosperous societies, and comes before maintaining harmony in the ecosystem. This order sustains the active-reactive dynamics of the double movement and limits the possibilities of change in global governance.
Evapotranspiration Climatology of Indiana Using In Situ and Remotely Sensed Products
Authors: Niyogi Dev , Jamshidi Sajad , Smith David , Kellner Olivia 
Published: October 2020

AbstractAn intercomparison of multiresolution evapotranspiration (ET) datasets with reference to ground-based measurements for the development of regional reference (ETref) and actual (ETa) evapotranspiration maps over Indiana is presented. A representative ETref equation for the state is identified by evaluating 10 years of in situ measurements (2009–19). A statewide ETref climatology is developed using the ETref equation and high-resolution surface meteorological data from the gridded surface meteorological dataset (gridMET). For ETa analyses, MODIS, Simplified Surface Energy Balance Operational dataset (SSEBop), Global Land Evaporation Amsterdam Model (GLEAM) (versions 3.3a and 3.3b), and NLDAS (Noah and VIC) datasets are evaluated using AmeriFlux data. Thirty years of rainfall data from Climate Hazards Group Infrared Precipitation with Station Data Rainfall (CHIRPS) are used with the ET datasets to develop effective precipitation fields. Results show that the standardized Penman–Monteith equation performs as the best ETref equation with median symmetric accuracy (MSA) of 0.37, Taylor’s skill score (TSC) of 0.89, and r2 = 0.83. The analysis shows that the gridMET dataset overestimates wind speed and requires adjustment before a series of statewide ETref climatology maps are generated (1990–2020). For ETa, the MODIS and GLEAM (3.3b) datasets outperform the rest, with MSA = 0.5, TSC = 0.8, and r2 = 0.8. The state ETa dataset is generated using all MODIS data from 2003 and blending the MODIS data with GLEAM (3.3b) to cover data unavailability. Using the top-performing datasets, annual ETref for Indiana is computed as 1110 mm, ETa as 708 mm, and precipitation as 1091 mm. A marginal increasing climatological trend is found for Indiana’s ETref (0.013 mm yr−1) while ETa is found to be relatively stable. The state’s water availability, defined as rainfall minus ETa, has remained positive and stable at 0.99 mm day−1 (annual magnitude of +3820 mm).
Clinical outcomes of posterior laminectomy and pedicle screw fixation for upper cervical intraspinal tumors: a case series
Authors: Chen Zhida , Yu Hui , Song Chao , Zhang Li , Wu Jin , Xiao Lili , Lin Bin 
Published: October 2020

Objective This study was performed to introduce posterior laminectomy and pedicle screw fixation for the treatment of upper cervical spinal cord tumors and investigate the curative effects. Methods Eighteen patients (11 men, 7 women) who underwent surgical treatment of an upper cervical intraspinal tumor from January 2008 to June 2013 were reviewed. Clinical parameters including age, sex, affected spinal levels, lesion location, duration and type of symptoms, and pathological features were retrospectively investigated. Results The mean operation time was 181.9 ± 25.5 minutes (range, 135–240 minutes), and the mean blood loss volume was 1038.9 ± 284.2 mL (range, 750–1530 mL). The Frankel grade, Japanese Orthopaedic Association score, and Karnofsky performance status score were significantly better postoperatively than preoperatively. The radiographic examination revealed good bone graft fusion. Two patients developed tumor recurrence, while four patients developed intraoperative or postoperative complications. Conclusions Management of upper cervical intraspinal tumors by posterior laminectomy and pedicle screw fixation can relieve compression of the cervical cord and nerve root, thoroughly remove the tumor lesion, reconstruct the stability of the upper cervical spine, and improve patients’ quality of life.
Correlation Between N-Terminal Pro-Brain Natriuretic Peptide Levels and Cardiopulmonary Exercise Testing in Patients With Pre-Capillary Pulmonary Hypertension: A Pilot Study
Authors: Aueyingsak Sahachat , Khrisanapant Wilaiwan , Kukongviriyapun Upa , Pasurivong Orapin , Ratanawatkul Pailin , Wanitpongpan Chinadol , Pussadhamma Burabha 
Published: October 2020

Background:N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiopulmonary exercise testing (CPET) are useful for severity assessment in patients with pulmonary hypertension (PH). Correlations between these tests in pre-capillary PH patients is less well studied.Methods:We studied 23 patients with pre-capillary PH: 8 with idiopathic pulmonary arterial hypertension (IPAH), 6 with systemic sclerosis-associated PAH (SSc-PAH), and 9 with chronic thromboembolic pulmonary hypertension (CTEPH). Clinical evaluation, NT-proBNP levels, six-minute walking test (6MWT), spirometry, and CPET were evaluated on the same day. Correlation between NT-proBNP levels and CPET parameters were investigated.Results:In all patients, NT-proBNP levels were significantly correlated with peak oxygen uptake (VO2) ( r = −0.47), peak oxygen pulse ( r = −0.43), peak cardiac output (CO) ( r = −0.57), peak end-tidal partial pressure of carbon dioxide (PETCO2) ( r = −0.74), ventilatory equivalent to carbon dioxide (VE/VCO2) at anaerobic threshold (AT) ( r = 0.73), and VE/VCO2slope ( r = 0.64). Significant correlations between NT-proBNP levels and peak PETCO2and VE/VCO2were found in IPAH and CTEPH subgroups, and a significant correlation between NT-proBNP levels and VO2at AT was found in the CTEPH subgroup. No significant correlation was found in the SSc-PAH subgroup.Conclusion:NT-proBNP levels were significantly correlated with CPET parameters in patients with IPAH and CTEPH subgroups, but not in SSc-PAH subgroup. A further study with larger population is required to confirm these preliminary findings.
Holistic Patient Assessment: Dermatology in Dental Practice
Authors: Chapireau David , Bashir Saqib J. , Fan Kathleen 
Published: October 2020

As part of the holistic approach to their patients, General Dental Practitioners are well placed to identify common skin lesions. Awareness and recognition of worrying lesions allow timely and appropriate referrals for further investigation and treatment. In this paper, we review benign, premalignant and malignant skin lesions, as well as genetic skin conditions. Past medical, family and social history (including sun exposure and previous cutaneous malignancy) is important. Examination includes the lesion, the skin type and the regional lymph nodes. The different common lesions are described, and the epidemiology, clinical features and treatment are discussed. Screening for skin lesions on the head and neck may be undertaken as part of overall dental care as part of the holistic examination of patients. Particularly with precancerous lesions and skin cancer, an early detection and referral from a dentist can expedite treatment and improve prognosis.
Next-generation sequencing of 35 RHD variants in 16 253 serologically D− pregnant women in the Finnish population
Authors: Tammi Silja M. , Tounsi Wajnat A. , Sainio Susanna , Kiernan Michele , Avent Neil D. , Madgett Tracey E. , Haimila Katri 
Published: October 2020

AbstractFetal RHD screening for targeted routine antenatal anti-D prophylaxis has been implemented in many countries, including Finland, since the 2010s. Comprehensive knowledge of the RHD polymorphism in the population is essential for the performance and safety of the anti-D prophylaxis program. During the first 3 years of the national screening program in Finland, over 16 000 samples from RhD− women were screened for fetal RHD; among them, 79 samples (0.5%) containing a maternal variant allele were detected. Of the detected maternal variants, 35 cases remained inconclusive using the traditional genotyping methods and required further analysis by next-generation sequencing (NGS) of the whole RHD gene to uncover the variant allele. In addition to the 13 RHD variants that have been previously reported in different populations, 8 novel variants were also detected, indicating that there is more variation of RHD in the RhD− Finnish population than has been previously known. Three of the novel alleles were identified in multiple samples; thus, they are likely specific to the original Finnish population. National screening has thus provided new information about the diversity of RHD variants in the Finnish population. The results show that NGS is a powerful method for genotyping the highly polymorphic RHD gene compared with traditional methods that rely on the detection of specific nucleotides by polymerase chain reaction amplification.
The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19
Authors: Hoiland Ryan L. , Fergusson Nicholas A. , Mitra Anish R. , Griesdale Donald E. G. , Devine Dana V. , Stukas Sophie , Cooper Jennifer , Thiara Sonny , Foster Denise , Chen Luke Y. C. , Lee Agnes Y. Y. , Conway Edward M. , Wellington Cheryl L. , Sekhon Mypinder S. 
Published: October 2020

Abstract
Studies on severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) suggest a protective effect of anti-A antibodies against viral cell entry that may hold relevance for SARS-CoV-2 infection. Therefore, we aimed to determine whether ABO blood groups are associated with different severities of COVID-19. We conducted a multicenter retrospective analysis and nested prospective observational substudy of critically ill patients with COVID-19. We collected data pertaining to age, sex, comorbidities, dates of symptom onset, hospital admission, intensive care unit (ICU) admission, mechanical ventilation, continuous renal replacement therapy (CRRT), standard laboratory parameters, and serum inflammatory cytokines. National (N = 398 671; P = .38) and provincial (n = 62 246; P = .60) ABO blood group distributions did not differ from our cohort (n = 95). A higher proportion of COVID-19 patients with blood group A or AB required mechanical ventilation (P = .02) and CRRT (P = .004) and had a longer ICU stay (P = .03) compared with patients with blood group O or B. Blood group A or AB also had an increased probability of requiring mechanical ventilation and CRRT after adjusting for age, sex, and presence of ≥1 comorbidity. Inflammatory cytokines did not differ between patients with blood group A or AB (n = 11) vs O or B (n = 14; P &gt; .10 for all cytokines). Collectively, our data indicate that critically ill COVID-19 patients with blood group A or AB are at increased risk for requiring mechanical ventilation, CRRT, and prolonged ICU admission compared with patients with blood group O or B. Further work is needed to understand the underlying mechanisms.
Algae-meditated route to cuprous oxide (Cu2O) nanoparticle: differential expression profile of MALAT1 and GAS5 LncRNAs and cytotoxic effect in human breast cancer
Authors: Taherzadeh-Soureshjani Parisa , Chehelgerdi Mohammad 
Published: October 2020

Abstract
Background
Breast cancer (BC), as the most widely recognized disease in women worldwide, represents about 30% of all cancers impacting women. This study was aimed to synthesize Cu2O nanoparticles from the cystoseira myrica algae (CM-Cu2O NPs) assess their antimicrobial activity against pathogenic bacteria and fungi. We evaluated the expression levels of lncRNAs (MALAT1 and GAS5) and apoptosis genes (p53, p27, bax, bcl2 and caspase3), their prognostic roles.

Methods
In this study, CM-Cu2O NPs synthesized by cystoseira myrica algae extraction used to evaluate its cytotoxicity and apoptotic properties on MDA-MB-231, SKBR3 and T-47D BC cell lines compared to HDF control cell line. The CM-Cu2O NPs was characterized by UV–Vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Transmission electron microscopy (TEM) and Scanning electron microscopy (SEM). The antimicrobial activity of CM-Cu2O NPs was assessed against pathogenic bacteria, staphylococcus aureus (S. aureus) PTCC 1112 bacteria as a standard gram-positive bacteria and pseudomonas aeruginosa (P. aeruginosa) PTCC 1310 as a standard gram-negative bacterium. Expression profile of MALAT1 and GAS5 lncRNAs and apoptosis genes, i.e., p27, bax, bcl2 and caspase3 genes, were calculated utilizing qRT-PCR. The changes in the expression levels were determined using the DDCT method.

Results
MALAT1 was upregulated in MDA-MB-231, SKBR3 and T-47D BC (p < 0.01), while GAS5 was downregulated in SKBR3 and T-47D cell lines tested compared with HDF control cell line (p < 0.05) was found. The results revealed that, p27, bax and caspase3 were significantly upregulated in BC cell lines as compared with normal cell line. Bcl2 expression was also significantly increased in MDA-MB-231 and T47D cell lines compared with normal cell line, but bcl2 levels were downregulated in SKBR3 cell line.

Conclusions
Our results confirm the beneficial cytotoxic effects of green-synthesized CM-Cu2O NPs on BC cell lines. This nanoparticle decreased angiogenesis and induces apoptosis, so we conclude that CM-Cu2O NPs can be used as a supplemental drug in cancer treatments. Significantly, elevated circulating lncRNAs were demonstrated to be BC specific and could differentiate BC cell lines from the normal cell lines. It was demonstrated that lncRNAs used in this study and their expression profiles can be created as biomarkers for early diagnosis and prognosis of BC. Further studies utilizing patients would give recognizable identification of lncRNAs as key players in intercellular interactions.