bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transforming Growth Factor Beta-Activated Kinase 1–Dependent Microglial and Macrophage Responses Aggravate Long-Term Outcomes After Ischemic Stroke
Authors: Wang Rongrong , Pu Hongjian , Ye Qing , Jiang Ming , Chen Jie , Zhao Jingyan , Li Sicheng , Liu Yaan , Hu Xiaoming , Rocha Marcelo , Jadhav Ashutosh P. , Chen Jun , Shi Yejie 
Published: February 2020

Background and Purpose—
Microglia/macrophages (Mi/MΦ) can profoundly influence stroke outcomes by acquiring functionally dominant phenotypes (proinflammatory or anti-inflammatory; deleterious or salutary). Identification of the molecular mechanisms that dictate the functional status of Mi/MΦ after brain ischemia/reperfusion may reveal novel therapeutic targets for stroke. We hypothesized that activation of TAK1 (transforming growth factor beta-activated kinase 1), a key MAP3K upstream of multiple inflammation-regulating pathways, drives Mi/MΦ toward a proinflammatory phenotype and potentiates ischemia/reperfusion brain injury.

Methods—
Young adult mice were subjected to 1 hour of middle cerebral artery occlusion (MCAO) followed by reperfusion. TAK1 was targeted by tamoxifen-induced Mi/MΦ-specific knockout or administration of a selective inhibitor 5Z-7-Oxozeaenol after MCAO. Neurobehavioral deficits and long-term gray matter and white matter injury were assessed up to 35 days after MCAO. Mi/MΦ functional status and brain inflammatory profiles were assessed 3 days after MCAO by RNA-seq, flow cytometry, and immunohistochemistry.

Results—

TAK1 Mi/MΦ-specific knockout markedly ameliorated neurological deficits in the rotarod and cylinder tests for at least 35 days after MCAO. Mechanistically, RNA-seq of purified brain Mi/MΦ demonstrated that proinflammatory genes and their predicted biological functions were downregulated or inhibited in microglia and macrophages from TAK1 Mi/MΦ-specific knockout mice versus WT mice 3 days after MCAO. Consistent with the anti-inflammatory phenotype of Mi/MΦ-specific knockout, oxozeaenol treatment mitigated neuroinflammation 3 days after MCAO, manifested by less Iba1
+
/CD16
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proinflammatory Mi/MΦ and suppressed brain invasion of various peripheral immune cells. Oxozeaenol treatment beginning 2 hours after MCAO improved long-term sensorimotor and cognitive functions in the foot fault, rotarod, and water maze tests. Furthermore, Oxozeaenol promoted both gray matter and white matter integrity 35 days after MCAO.

Conclusions—
TAK1 promotes ischemia/reperfusion-induced inflammation, brain injury, and maladaptive behavior by enhancing proinflammatory and deleterious Mi/MΦ responses. Therefore, TAK1 inhibition is a promising therapy to improve long-term stroke outcomes.
Shoring Up Sappho
Authors: de Kreij Mark , Colomo Daniela , Lui Andrew 
Published: February 2020

Abstract
P.Oxy. 2288, a 2nd-century fragment containing Sappho’s Ode to Aphrodite, has an underlying layer of papyrus that has intrigued scholars for decades. X-ray tomography of the papyrus and a study of the ink under the scanning electron microscope allow us to establish that the underlying layer most likely does not contain more of Sappho’s poetry. Rather, it appears that P.Oxy. 2288 is what remains of a much-used roll of Sappho book 1, reinforced at its beginning. In order to put this case in its historical context, the second part of the article contains a new examination of the literary, documentary, and papyrological evidence for ancient repairs and reinforcements of bookrolls.
Distribution pattern and habitat shifts during ontogeny of the blue swimming crab, Portunus pelagicus (Linnaeus, 1758) (Brachyura, Portunidae)
Authors: Hisam Fazrul , Hajisamae Sukree , Ikhwanuddin Mohammed , Pradit Siriporn 
Published: February 2020

Abstract
This study determined the distribution and ontogenetic habitat shifts of Portunus pelagicus in coastal habitats in Thailand. Samples were collected by gill nets and traps, at six study sites during May 2013 and September 2014. It was found that, in the bay, the catches from both gears were significantly influenced by depth ( and ) but not by season (). For offshore, the catch was significantly influenced by season () but not by depth (). The catches of berried females in the bay and in the offshore area were not influenced either by depth, or by season (). In addition, it is proven by this study that a habitat shift during ontogeny occurs as young crabs or small-sized crabs inhabit shallow waters, and migrate to deeper water when they grow larger.
Quantitative analysis of carapace pattern polymorphism in the grapsid crab Hemigrapsus penicillatus (De Haan, 1835) (Decapoda, Varunidae)
Authors: Kim Yongsu , Bae Sangryong , Kang Changku 
Published: February 2020

Abstract
Many shore crabs exhibit juvenile colour pattern polymorphism on their carapace, which helps avoid predation through camouflage. However, colour pattern polymorphism has been described only in a limited number of species, and its quantitative descriptions are rare. Here, we studied the Asian grapsid crab Hemigrapsus penicillatus to describe its polymorphic dichromatic carapace patterns. We specifically examined how dichromatic patterns and the degree of pattern polymorphism change as size increases and whether sexual/size differences exist in carapace patterns. Our results showed that H. penicillatus exhibits polymorphic forms in both the juvenile and adult stages. Additionally, compared with males, females were more likely to exhibit dichromatic carapace patterns and had a larger light-coloured area on their carapace. Estimation of the likelihood of the carapace being light or dark coloured suggested that certain areas on the carapace are less variable than other areas. We discuss potential adaptive explanations for our results.
Crustaceans from shrimp by-catch from the southeastern Gulf of California to the southeastern Mexican Pacific: implications in their community structure and reproduction
Authors: Tirado-Ibarra Jorge de Jesus , Jimenez-Gutierrez Stephanie , Acuña-Carvajal Cristina , Muñoz-Garcia Isabel , Martinez-Perez Francisco , Rodriguez-Dominguez Guillermo , Perez-Gonzalez Raul , Jimenez-Gutierrez Laura R. 
Published: February 2020

Abstract
In tropical countries, a large number of finfish species and invertebrates are captured as by-catch, including several species of crustaceans, due to the low selectivity of the fishing methods. By-catch presents and optimal opportunity to study populations of crustaceans. Here, the goal was to determine the community structure, specifically through the size structure, as well as the average sizes at first maturity of crustacean species present in the shrimp by-catch caught aboard a fishing vessel operating in the Mexican Pacific, from Sinaloa to Guerrero, Mexico. From the 18 crustaceans found in this study, the crabs Euphylax robustus and Achelous asper were the dominant species, whereas four species were considered casual (i.e., not frequent). Interestingly, more than 40% of the organisms analysed were in the juvenile stage, and 19% were ovigerous females. The results demonstrate the negative impact of the low selectivity of shrimp trawls on the communities of species of Crustacea.
A new species of Paramacrochiron (Copepoda, Cyclopoida) parasitic on the rhizostome medusa Versuriga anadyoneme (Maas, 1903) collected from Vietnam
Authors: Ohtsuka Susumu , Ha Tran Manh , Thu Pham The 
Published: February 2020

Abstract
A new species of the cyclopoid copepod genus Paramacrochiron, P. tridentatum, which is parasitic on the rhizostome medusa, Versuriga anadyoneme (Maas, 1903), is described from Vietnam. This is the tenth species within the genus. The new species is distinguishable from other congeners by the combination of the following features: (1) female second maxillipedal segment with 3 acutely pointed processes terminally; (2) female leg 4 endopod as long as or slightly longer than exopod; (3) male maxilliped with a small, acutely pointed process at subterminal corner of the first segment and a row of relatively coarse spinules along the inner margin of the second segment. The present study most probably implies a high species diversity of Paramacrochiron in the tropical and subtropical waters of the Indo-West Pacific region.
A revision of Cylindromorphoidina: Comparative morphology, genera reassessment and description of new species (Coleoptera, Buprestidae, Agrilinae)
Authors: Migliore Letizia J. , Biffi Gabriel , Curletti Gianfranco 
Published: February 2020

Abstract
The subtribe Cylindromorphoidina Cobos, 1979, the only representative of tribe Aphanisticini in the Neotropical region, is currently composed of two genera, Eurynodes Théry, 1934 and Cylindromorphoides Kerremans, 1903. The genus Taphroceroides Hespenheide, 2007, originally proposed in Cylindromorphoidina, is currently placed in Brachyina (tribe Tracheini). A detailed morphological comparison of Taphroceroides species with members of Eurynodes and Cylindromorphoides shows similarities that strongly support their transference back to Cylindromorphoidina. A new morphological definition and classification of Cylindromorphoidina is presented along with the description of new species in the three genera: Eurynodes gemmatus sp. nov., E. capillatus sp. nov., Cylindromorphoides ferrugifrons sp. nov., Taphroceroides brunneus sp. nov., and T. brasiliensis sp. nov. Photographs and comments on the type series of previously described species are provided. New biological data and possible association of Cylindromorphoidina species with Bromeliaceae are reported. Finally, a distribution map is provided for all species of Cylindromorphoidina.
Trend Analysis of Multiple Extreme Hourly Precipitation Time Series in the Southeastern United States
Authors: Brown Vincent M. , Keim Barry D. , Black Alan W. 
Published: February 2020

AbstractAnnual trends in extreme hourly precipitation time series were examined at 50 first-order weather stations across the southeastern United States from 1960 to 2017. Results indicated that the magnitude of annual maximum 1-, 3-, 6-, 12-, and 18-h periods did not broadly change at the sites analyzed; however, the numerical value that defines a (station specific) 90th-percentile hourly accumulation significantly (p ≤ 0.05) increased at 36% (18/50) of the stations. No station had a significant decreasing trend in annual 90th-percentile hourly event magnitude. Stations in Texas observed the largest increase in annual 90th-percentile hourly event magnitude, where parameter estimates showed increases of 0.20%–0.26% per year. Annual average dry-spell duration, defined as the average number of hours between measurable precipitation events, significantly decreased at 18% (9/50) of sites analyzed. Parameter estimates from regression performed on average dry-spell-duration time series showed decreases of roughly 0.11%–0.19% per year for the stations across southern Florida. Six stations across Georgia showed significant decreasing trends in the annual maximum consecutive hourly period with measurable precipitation (duration), demonstrating that the longest precipitation events that occurred at these stations have decreased in duration since 1960.
A 30-Yr Climatology of Meteorological Conditions Associated with Lightning Days in the Interior Western United States
Authors: Kalashnikov Dmitri A. , Loikith Paul C. , Catalano Arielle J. , Waliser Duane E. , Lee Huikyo , Abatzoglou John T. 
Published: February 2020

AbstractA 30-yr climatology of lightning days and associated synoptic meteorological patterns are characterized across the interior western United States (WUS). Locally centered composite analyses show preferred synoptic meteorological patterns with positive 500-hPa geopotential height anomalies located to the northeast and negative sea level pressure anomalies to the northwest and collocated with local lightning days. Variations in preferred patterns for local lightning days are seen across the interior WUS. Areas not commonly affected by the North American monsoon system including the western Great Basin and northern Rocky Mountains show higher-amplitude anomalies of geopotential height, moisture, and midtropospheric instability patterns suggesting the importance of episodic midlatitude dynamics to lightning days in such locations. By contrast, locations closer to the core of the North American monsoon show weaker anomalies, likely reflecting the prevalence of favorable mesoscale dynamics key to lightning production during warm-season months in locations in the interior Southwest. Meteorological patterns for select locations are explored in more detail and two case studies of notably active lightning events are presented. Results from this observational analysis provide a foundation for evaluating meteorological conditions on lightning days in climate model simulations for the interior WUS.
Roles and responsibilities of behavioral science faculty in inpatient medicine
Authors: Sudano Laura E , Reitz Randall 
Published: February 2020

Objective Behavioral science faculty in family medicine residencies work on inpatient medicine teaching service settings. However, there is limited research on the roles and responsibilities that behavioral science faculty fill while working in such settings. Method Using a modified sequential explanatory study, researchers clarified the roles and responsibilities of behavioral science faculty. Participants completed a web-based survey ( N = 60) on roles and a semistructured interview ( N = 24) about the responsibilities on inpatient medicine teaching service. Results Results suggest that behavioral science faculty assume the roles of educator, patient care supporter, evaluator, mentor/advisor, and scholar/researcher and perform multiple responsibilities. Conclusions Implications for this research inform the hiring process and training for behavioral science faculty and resident education.
Physician and behavioral health provider diagnostic agreement in a general hospital setting
Authors: Lawrence Tyler J , Harsh Jennifer S , Lyden Liz 
Published: February 2020

Objective Behavioral health providers are often employed in inpatient settings. However, it is unclear if there is mental health diagnosis agreement between referring physicians and behavioral health providers. The purpose of this study is to assess for referring physician and behavioral health provider mental health diagnostic agreement in a general hospital setting. Method An analysis of 60 consecutive inpatient referrals to a behavioral health provider in a general hospital setting was conducted. The initial referral diagnosis from referring internal medicine physicians was compared with the diagnosis made by the behavioral health provider. Results Kappa statistics indicated good diagnostic agreement for substance abuse (.79), anxiety disorders (.82), adjustment disorders (.88), relational conflict (.88), and “other” (.74). There was less agreement for depressive disorders (.55). Conclusions Diagnostic agreement was good overall, suggesting that referrals to inpatient behavioral health providers are often appropriate. Results indicated that depression was underdiagnosed by physicians in the study sample. This is problematic given that depression can be successfully treated through the use of medication and psychotherapy.
Effectiveness of interventions aimed at improving the sexuality of women with multiple sclerosis: a systematic review
Authors: Esteve-Ríos Antonio , Garcia-Sanjuan Sofia , Oliver-Roig Antonio , Cabañero-Martínez María José 
Published: February 2020

Objective: To evaluate the effectiveness of interventions aimed at improving the sexuality of women with multiple sclerosis. Data sources: MEDLINE, CINAHL, PsycINFO, Web of Science, Scopus, Embase and the Cochrane Library, as well as doctoral thesis databases Teseo and ProQuest Dissertations & Theses Global and the grey literature database Opengrey were searched, last on 15 October 2019. Journals related to the topic were also consulted. The bibliographic references of the articles included were reviewed. Method: Studies were selected if they included women with multiple sclerosis in whom interventions aimed at reducing sexual dysfunction were applied. Data extraction was carried out by two independent reviewers. The Jadad scale was used to evaluate the methodological quality of the studies included. Results: In total, 12 clinical trials were selected, and 611 patients were examined. Studies were classified into six interventions: sexual therapy (4), pharmaceutical drugs (3), pelvic floor exercises (2), yoga (1), mindfulness (1) and vaginal devices (1). Most of them improved some primary outcomes of sexual dysfunction such as lubrication, arousal, desire or orgasm. Pain was the most common secondary outcome evaluated and it became better in two studies including sexual therapy and in one intervention with pelvic floor exercises. Tertiary outcomes such as anxiety or depression were rarely examined, and they improved with sexual therapy and with OnabotulinumtoxinA. Conclusion: Sexual therapy, administration of OnabotulinumtoxinA, pelvic floor muscles exercises alone or combined with electrostimulation and the use of clitoral devices could be the most recommended interventions to improve the sexuality in women with multiple sclerosis.
Pulmonary tuberculosis in a cohort of forensic autopsies: a preliminary study from Saudi Arabia
Authors: Madadin Mohammed , Menezes Ritesh G. , Al Tamimi Dalal M. , Kharoshah Magdy A. , Al Hamad Mohammad , Al-Nasser Mona , Al Madani Osama M. 
Published: February 2020

Aims The purpose of this study was to identify any cases of previously undiagnosed pulmonary tuberculosis during autopsy. Methods This prospective study investigated a cohort of deceased individuals that underwent a full external and internal postmortem examination at the Forensic Medicine Centre, Dammam, Saudi Arabia. Gross pathology, histopathology and molecular pathology were used to identify pulmonary tuberculosis in forensic autopsy samples from the lungs. Results A total of 82 cases autopsied were included in the study. The mean ± SD age of the study cohort was 35.5 ± 10.3 years (range, 20–80 years). Males ( n = 70; 85.37%) outnumbered females. The deceased were from 15 different countries. The number of Saudis was 16 (19.51%). The maximum number of non-Saudis was from India with 26 cases (31.71%). There were no cases of undiagnosed pulmonary tuberculosis detected for the first time at autopsy. Conclusions Although the prevalence of pulmonary tuberculosis in forensic autopsy cases in this preliminary study was nil, we recommend further studies to be conducted on a larger scale and in different autopsy centres throughout Saudi Arabia to get an insight into the burden of clinically undiagnosed tuberculosis in the entire country.
Efficacy of intracuff lidocaine in reducing coughing on tube: a systematic review and meta-analysis
Authors: Peng Fei , Wang Maohua , Yang Huihuang , Yang Xiaoli , Long Menghong 
Published: February 2020

Objective To investigate the efficacy of intracuff lidocaine in reducing coughing and other endotracheal tube side effects and so ensure a smooth extubation process. Method PubMed, EMBASE, and Cochrane Library databases were systematically searched for all randomised controlled trials (RCTs) published before June 30, 2019 that investigated the efficacy of intracuff lidocaine, with or without sodium bicarbonate, in reducing coughing and other complications related to endotracheal intubation. A random-effects model was used to conduct a meta-analysis to assess the relative risks (RRs) of the incidence of these intubation-related side effects. Results 11 studies involving 843 patients were included in the meta-analysis. Compared with control groups (i.e., saline or air), intracuff lidocaine groups (alkalinized or non-alkalinized) had a significantly reduced incidence of coughing on tube. Similarly, intracuff lidocaine groups were more effective than control groups in reducing the incidence of other intubation-related complications. Conclusion Intracuff alkalinized or non-alkalinized lidocaine significantly reduced coughing and other intubation-related complications during the extubation process.
The experiences of people with severe mental health conditions participating in the Occupation Matters Programme: An interpretative phenomenological analysis
Authors: Newport Alison , Clarke Channine 
Published: February 2020

Introduction The Occupation Matters Programme is an occupational therapy intervention promoting recovery in people with severe mental health conditions, adapted from the Lifestyle Redesign© approach. With the increasing demand for mental health services and the United Kingdom’s current financial position, there is reason to research the Occupation Matters Programme. Method Interpretative phenomenological analysis provided a rich account of the experience of the Occupation Matters Programme, eliciting the service user voice. Four participants participated in semi-structured interviews following session 10 and at the completion of the 20-week programme. Data analysis followed the step-by-step interpretative phenomenological analysis guidelines, enabling themes to be identified that reflected participants’ experiences. Findings Three major themes were revealed: connecting with others; experiencing an opened-up world through a temporary project and finding a place in the world through a changing sense of self. Three participants described a temporary improvement in their mental health at the halfway point, which became more permanent by the completion of the programme. Conclusions This study suggests that the Occupation Matters Programme was influential in the participants’ recovery journeys and provides evidence for Wilcock’s Doing, Being, Belonging and Becoming framework. It encourages occupational therapists to concentrate on occupation-centred practice, occupational integrity and implementing all four aspects of Wilcock’s framework.