bluuebunny/crossref_metadata_2025_split huggingface dataset:
New strategy using laparoscopic hepatectomy for an intrahepatic portal‐hepatic venous shunt with hyperammonemia (with video)
Authors: Yasuda Jungo , Shiozaki Hironori , Futagawa Yasuro , Okamoto Tomoyoshi , Ikegami Toru 
Published: December 2024

AbstractIntrahepatic portal and hepatic venous shunts have been reported in children (Takama et al. Surg Case Rep 2020;6(1):73) but are very rare in adults (Papamichail et al. Hepatobiliary Pancreat Dis Int 2016;15(3):329–333). Treatment is indicated in cases of portal hypertension or hyperammonemia. We evaluated and reported the usefulness, safety, and effectiveness of laparoscopic liver resection for this case. After performing intraoperative ultrasonography, the hilar plate was manipulated to identify the target Glissonean branch of segment 5 (G5). Bulldog forceps were then used for test clamping, which was identified by negative staining, Segment 5 was dissected and hepatic parenchymal resection was performed. The hepatic veins running within the ischemic area were dissected, and hepatic parenchymal resection, including intrahepatic portal and hepatic venous shunts, was performed. The operation time was 257 min, and she was discharged on the 8th postoperative day, with no complications. Serum ammonia levels decreased rapidly postoperatively. Laparoscopic liver resection may be effective for intrahepatic portal and hepatic venous shunts.
On not wanting to know: Some thoughts on Kazuo Ishiguro's novel Never Let Me Go
Authors: Wieland Christina 
Published: December 2024

AbstractKazuo Ishiguro's dystopian novel Never Let Me Go takes place, as the author tells us in ‘England, the late 1990s’ and follows the lives of a group of clones who had been created with the sole purpose of harvesting their organs for transplant. The novel is steeped in an atmosphere of illusion and self‐deception while remaining deeply rooted in human emotions. I argue that to some extent it represents all of us, our illusions and self‐deceptions. At another level, however, I argue that the novel is a sharp critique of a culture of narcissism and self‐interest where human beings are treated as commodities, while creating the illusion that they are special and that ‘they never had it so good’, a saying from another time when self‐deception was equally promoted. The paper concentrates on one aspect of this multilayered novel—the misrepresentation of reality and the human wish not to know about painful truths, but instead to create an illusory world. It examines this aspect of the novel in terms of the current neoliberal framework, and the culture of illusion that it promotes by ignoring the violence that underlies it. In particular, it examines how this pervasive aspect of contemporary culture affects the ability of the individual to ask questions and to pursue the truth, what Bion called ‘K.’
International licensing and quality‐enhancing technology spillover in a product cycle model
Authors: Yu Po‐yang , Beladi Hamid , Chu Hsun , Lai Ching‐chong 
Published: December 2024

AbstractThis paper examines the effects of an international quality‐enhancing technology spillover on the international industry distribution and innovation in a dynamic North‐South model. When a Southern firm receives a technology transfer from the North through international licensing, the technology spills over to other Southern firms by enhancing the quality of their products. We find that a stronger spillover effect depresses both Northern innovative R&D and Southern adaptive R&D, and thus is welfare‐impairing both for the advanced country and recipient country. The results cast doubt on the common view that regards the technology spillover as a positive externality.
Predicting fine‐scale distributions and emergent spatiotemporal patterns from temporally dynamic step selection simulations
Authors: Forrest Scott W. , Pagendam Dan , Bode Michael , Drovandi Christopher , Potts Jonathan R. , Perry Justin , Vanderduys Eric , Hoskins Andrew J. 
Published: December 2024

Understanding and predicting animal movement is fundamental to ecology and conservation management. Models that estimate and then predict animal movement and habitat selection parameters underpin diverse conservation applications, from mitigating invasive species spread to enhancing landscape connectivity. However, many predictive models overlook fine‐scale temporal dynamics within their predictions, despite animals often displaying fine‐scale behavioural variability that might significantly alter their movement, habitat selection and distribution over time. Incorporating fine‐scale temporal dynamics, such as circadian rhythms, within predictive models might reduce the averaging out of such behaviours, thereby enhancing our ability to make predictions in both the short and long term. We tested whether the inclusion of fine‐scale temporal dynamics improved both fine‐scale (hourly) and long‐term (seasonal) spatial predictions for a significant invasive species of northern Australia, the water buffalo Bubalus bubalis. Water buffalo require intensive management actions over vast, remote areas and display distinct circadian rhythms linked to habitat use. To inform management operations we generated hourly and dry season prediction maps by simulating trajectories from static and temporally dynamic step selection functions (SSFs) that were fitted to the GPS data of 13 water buffalo. We found that simulations generated from temporally dynamic models replicated the buffalo crepuscular movement patterns and dynamic habitat selection, resulting in more informative and accurate hourly predictions. Additionally, when the simulations were aggregated into long‐term predictions, the dynamic models were more accurate and better able to highlight areas of concentrated habitat use that might indicate high‐risk areas for environmental damage. Our findings emphasise the importance of incorporating fine‐scale temporal dynamics in predictive models for species with clear dynamic behavioural patterns. By integrating temporally dynamic processes into animal movement trajectories, we demonstrate an approach that can enhance conservation management strategies and deepen our understanding of ecological and behavioural patterns across multiple timescales.Keywords: circadian, fine‐scale dynamics, harmonics, landscape‐scale distributions, simulated trajectories, temporal dynamics
A Sequential Multiaxial Cycle Counting Algorithm Based on the Modified Wang–Brown Method
Authors: Zhang Shiyue , Wu Hao 
Published: December 2024

ABSTRACTRainflow algorithm is an essential and reasonable method for multiaxial fatigue damage calculation in nonproportional (NP) load histories. The modified Wang–Brown (MWB) method is proposed by Meggiolaro and Castro, which corrects the problem of neglecting the most damaging event in the Wang–Brown method. An example in the paper explains the specific process of MWB multiaxial rainflow counting. Additionally, a modified pseudocode is presented to efficiently implement loading counting, ensuring it follows the same sequence as the original load histories. Based on the count results and fatigue damage accumulation rule, a new multiaxial life prediction method is proposed. The efficiency of the proposed method is validated by reasonable correlations with the experimental data from 316L steel tubular specimens subjected to various multiaxial fatigue loadings.
Impact of short‐term ketogenic diet on sex hormones and glucose‐lipid metabolism in overweight or obese patients with polycystic ovary syndrome
Authors: Li Meng , Zhang Lisong , Li Xiaoyu , Zhao Yanzhong 
Published: December 2024

AbstractAimThis study evaluates the clinical effects of a ketogenic diet (KD) versus a traditional comprehensive intervention, including lifestyle changes and oral contraceptives, in overweight or obese polycystic ovary syndrome (PCOS) patients.MethodsA retrospective analysis of 70 overweight/obese PCOS patients (body mass index [BMI] ≥24 kg/m2) treated between December 2022 and December 2023 was conducted. The patients were categorized into two groups based on their past treatment modality: Group 1 received a KD treatment (N = 35), and Group 2 underwent comprehensive intervention (N = 35), with both treatments lasting 3 months. Changes in body weight, BMI, sex hormone levels, glucose‐lipid metabolism indicators, and liver and kidney function were compared.ResultsBoth groups experienced significant reductions in body weight and BMI after treatment (p < 0.05), with the KD group showing a greater reduction (p < 0.05). luteinizing hormone (LH), LH/follicle‐stimulating hormone (FSH), and total testosterone (TT) levels decreased significantly in both groups (p < 0.05). The KD treatment led to significant reductions in fasting blood glucose (FBG), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA‐IR), triglyceride (TG), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) (p < 0.05), while the comprehensive intervention resulted in decreased FBG and ALT, and increased high‐density lipoprotein‐cholesterol (HDL‐c) (p < 0.05). Additionally, the KD group had a greater reduction in FBG, and showed decreases in TG and AST, which remained unchanged in the comprehensive intervention group (p < 0.05).ConclusionThe short‐term KD treatment provides significant weight loss and effectively improves hormone regulation and glucose‐lipid metabolism in overweight or obese PCOS patients, offering a valuable therapeutic option for managing the condition.
Patient awareness of long‐term cardiovascular and metabolic disease risks after hypertensive disorders of pregnancy in Japan
Authors: Ushida Takafumi , Tano Sho , Matsuo Seiko , Fuma Kazuya , Imai Kenji , Kajiyama Hiroaki , Kotani Tomomi 
Published: December 2024

AbstractAimGiven the increasing recognition of the importance of postpartum follow‐up care for women with a history of hypertensive disorders of pregnancy (HDP) to mitigate their future risk of cardiovascular and metabolic diseases, here we aimed to evaluate the current status of postpartum follow‐up care in Japan and explore the challenges to its implementation.MethodsA web‐based survey was conducted using a smartphone application among postpartum women between March and May 2024 to assess their knowledge of HDP‐related future risk and postpartum follow‐up care.ResultsA total of 880 valid responses were obtained, 73 (8.3%) of which were from women with a history of HDP. Of them, 56.2% were aware of the heightened risk of cardiovascular disease and even fewer knew about the risks of metabolic syndrome (37.0%) and the preventive use of low‐dose aspirin (12.3%); in fact, 31.5% reported receiving no information about their risk or preventive measures from healthcare providers. Furthermore, 43.8% did not consult specialists or attend regular checkups after their 1‐month checkup. Among women with a history of HDP, those who received information and guidance were more likely to implement behavioral changes than those who did not.ConclusionsPatient awareness level of HDP‐related risk was low and the information provided by their healthcare professionals was insufficient, indicating that postpartum follow‐up care in Japan is not satisfactory. This study highlights the need for improved educational strategies and systematic follow‐up protocols to ensure that women are adequately informed and supported in managing their long‐term health risks.
Alpha‐1 Antitrypsin Inclusions Sequester GRP78 in a Bile Acid–Inducible Manner
Authors: Spivak Igor , Guldiken Nurdan , Usachov Valentyn , Schaap Frank , Damink Steven W.M. Olde , Bouchecareilh Marion , Lehmann Alexandra , Fu Lei , Mo Fa‐Rong , Ensari Gökce Kobazi , Hufnagel Franziska , Fromme Malin , Preisinger Christian , Strnad Pavel 
Published: December 2024

ABSTRACTBackground and AimsThe homozygous PiZ mutation (PIZZ genotype) constitutes the predominant cause of severe alpha‐1 antitrypsin (AAT) deficiency and leads to liver disease via hepatocellular AAT aggregation. We systematically analysed the composition of AAT aggregates and studied the impact of bile acids.MethodsAAT inclusions were isolated from livers of PiZ overexpressing mice and PIZZ humans via fluorescence‐activated and immunomagnetic sorting (FACS/MACS), while insoluble proteins were obtained via Triton‐X extraction. Inclusion composition was evaluated through mass‐spectrometry (MS), immunoblotting and immunostaining. Hepatocytes with versus without AAT aggregates were obtained via microdissection. Serum bile acids were assessed in 57 PIZZ subjects and 19 controls. Mice were administered 2% cholic acid (CA)–supplemented chow for 7 days.ResultsMS identified the key endoplasmic reticulum chaperone 78 kDa glucose‐regulated protein (GRP78) in FACS/MACS pulldowns. GRP78 was also enriched in insoluble fractions from PiZ mice versus wild types and detected in insoluble fractions/MACS isolates from PIZZ liver explants. In cultured cells/primary hepatocytes, PiZ overexpression was associated with increased GRP78 mRNA/protein levels. In human livers, hepatocytes with AAT aggregates had higher GRP78 levels than hepatocytes without. PIZZ subjects displayed higher serum bile acid levels than controls and the highest levels were seen in individuals with liver injury/fibrosis. In PiZ mice, CA‐mediated bile acid challenge resulted in increased liver injury and translocation of GRP78 into the aggregates.ConclusionsOur results demonstrate that GRP78 is sequestered within AAT inclusions. Bile acid accumulation, as seen in PIZZ subjects with liver disease, may promote GRP78 segregation and thereby augment liver damage.Trial Registration: NCT02929940
Additive Manufacturing of Wheat Straw Fibers for Sustainable Thermal Insulation Application
Authors: Guo Zipeng , Liang Licheng , Armstrong Jason , Ren Shenqiang , Zhou Chi 
Published: December 2024

Abstract
Thermal insulation materials reduce heat transfer and are typically made from materials like fiberglass, foam, or mineral wool, which are engineered to trap air and hinder heat conduction and convection. The traditional manufacturing processes of thermal insulation materials are often energy-intensive and result in significant greenhouse gas emissions. In the current global drive for sustainability, these energy-intensive manufacturing processes raise environmental concerns and need to be addressed. In this work, with the objective of addressing both material sustainability and manufacturing sustainability, we present an additive manufacturing strategy to fabricate biomass materials for thermal insulation applications. We propose utilizing wheat straw as a biomass feedstock for manufacturing sustainable thermal insulation. This approach captures carbon during growth and stores it within the insulation structure. In the presented work, we first demonstrate the formulation of a 3D-printable ink using chopped straw fibers. We conduct comprehensive rheological characterizations to reveal the shear-thinning properties and the printability of the straw fiber ink. Utilizing the direct ink writing (DIW) process, the straw fiber material is deposited into 3D structures. Through material characterization tests, which include microstructure, mechanical, and thermal analyses, we demonstrate the low thermal conductivity and robust mechanical properties. This paper marks the first work of 3D printing of wheat straw fibers for thermal insulation structures. The discoveries in this pilot work demonstrate the potential to leverage additive manufacturing technologies and sustainable biomass materials to create both functional and value-added wheat straw parts tailored for thermal insulation applications.
An Experimental Comparison of Methanol Combustion Strategies: Spark Ignition Versus Compression Ignition
Authors: Gandolfo John , Lawler Benjamin , Gainey Brian 
Published: December 2024

Abstract
Methanol has garnered significant attention over the past few years due to its potential as a hydrogen carrier in a future green economy. As a result, it is a leading candidate to displace fossil fuels in the transportation sector. Although recent research efforts have been directed toward adopting the fuel in compression ignition engines, methanol is an ideal fuel for light-duty high compression ratio spark ignition engines due to its fast laminar flame speed, high auto-ignition resistance, and high cooling potential. In this work, methanol was combusted in a single-cylinder spark ignition engine with a compression ratio of 14.8 and compared to E10 (regular grade gasoline – 10% ethanol, 90% ethanol by volume), E75 (75% ethanol, 25% gasoline by volume), and hydrous ethanol (92% ethanol, 8% water by mass) at 6 bar net indicated mean effective pressure (IMEPn). Methanol achieved a net fuel conversion efficiency of 42.5% compared to 41.6% with hydrous ethanol, 39.5% with E75, and 36.2% with E10. Next, the performance of the high compression ratio spark ignition engine was then compared to a methanol-fueled light-duty single-cylinder compression ignition engine. At loads of 6 bar and 10 bar IMEPn, the net fuel conversion efficiency of stoichiometric spark ignition was higher than lean mixing-controlled compression ignition by 2.6 and 3.3 percentage points, respectively. The net fuel conversion efficiency of mixing-controlled compression ignition was higher than spark ignition by 0.2 percentage points at a load of 16 bar IMEPn. The competitiveness of spark ignition with mixing-controlled compression ignition was due to the high thermodynamic penalty associated with injecting a high heat of vaporization fuel like methanol close to top dead center where heat from the working fluid is absorbed to evaporate the fuel rather than being converted to thermodynamic work. To remedy this, an advanced compression ignition strategy using premixed and partially premixed injections was demonstrated to provide the highest net fuel conversion efficiency across the tested combustion strategies by avoiding this thermodynamic penalty and taking full advantage of the lean and unthrottled nature of compression ignition.
Complete genome sequence of an
Escherichia coli
ST7366 strain harboring an extended-spectrum β-lactamase gene isolated from sewage water in Pakistan
Authors: Lee Jung Hun , Yasmin Saba , Kim Nam-Hoon , Jeong Chanyeong , Kang Byeonghyeon , Lee Gwangje , Kim Dae-Wi , Zahra Rabaab , Lee Sang Hee 
Published: December 2024

ABSTRACT

We announce the complete genome of
Escherichia coli
strain PEC1003 belonging to ST7366, isolated from sewage water in Pakistan. This strain harbored a plasmid carrying various antibiotic resistance genes, including extended-spectrum β-lactamase (ESBL),
bla
CTX-M-15
, emphasizing the management and surveillance of ESBL-producing
E. coli
in the environment of developing countries.
The Power of Poor AI: Exploring the Potential for Defiance and the Nature of Disruption
Authors: Lin Ziyao 
Published: December 2024

Abstract
This article explores the concept of “Poor AI,” drawing inspiration from Hito Steyerl’s notion of “Poor Images,” and examines the hidden digital labor within artificial intelligence (AI) development, revealing how AI systems, fueled by data collected from the digital proletariat, shape a force with the potential to disrupt established norms and challenge hierarchies. The hidden labor behind AI’s efficiency and its alignment with capitalist interests is uncovered. This investigation sheds light on the paradox of AI’s power, which simultaneously empowers and diminishes human agency, and its acceleration of inequality within the digital economy.
Sinitic Buddhist Liturgy in a Mongolian Guise: A Newly Discovered Mongolian Text Related to the Huayan Repentance Liturgy from Toyuq, Xinjiang
Authors: Xia Lidong , Huang Mengji , Wang Long 
Published: December 2024

Abstract
In 2015, a long scroll written in Uyghur-Mongolian script, along with a few fragments of a similar codicological type, was excavated at the site of Toyuq in Turfan. The Mongolian text that survives in the manuscripts is identified as part of an important Buddhist liturgical text that has come down to us in Chinese, Tangut, and Old Uyghur. This finding not only presents us for the first time with a Mongolian version of this liturgical text, but also allows us to further identify another fragmentary Mongolian manuscript acquired in Turfan in the early twentieth century that is currently housed at the Lüshun Museum in China as part of the same liturgical text. Aside from introducing the newly discovered manuscripts and explaining their archaeological context, this article also discusses the historical significance of the discovery and the new light it sheds on the history of the transmission and reception of the text.
Daoism in Sichuan: Leshan, Emeishan, and Li Xiyue’s Community in the Nineteenth Century
Authors: Valussi Elena 
Published: December 2024

Abstract
Sichuan and the surrounding region of south-west China has long been an active center of religious knowledge production, a node of religious networks that originate and/or develop within it and extend beyond it, and has given birth to important religious movements. This article attempts to uncover a part of the history of Daoism in Sichuan that has not been fully analyzed, in terms of the geographical area, the time period, the community, and the practices described. It discusses Li Xiyue 李西月 (1806–1856) an influential teacher, scholar and practitioner, and his community, the Western School of Daoism, located in the area of Leshan 樂山 and devoted to two popular gods: Zhang Sanfeng 張三丰 and Lüzu 呂祖. This article gives a comprehensive overview of this community through the description of its involvement in spirit writing and religious publishing, locating their activities in the wider constellation of communities also receiving and publishing religious scriptures in Sichuan. The article also recovers and makes more visible a different religious identity for mountains like Leshan and Emei, which have mostly been described as Buddhist, by highlighting how a Daoist community also inhabited, used, and was inspired by these places and spaces.
Diversifying Clean Hydrogen. Regulatory Barriers for a Circular Hydrogen Economy
Authors: Martín Morán Álvaro 
Published: December 2024

Abstract
As part of its pursuit of climate neutrality, the EU is promoting hydrogen as a key energy vector. Thus far, it has focused mainly on renewable hydrogen that is produced via electrolysis. There are plentiful opportunities to apply the principles of the circular economy to the production of hydrogen and, thus, to diversify the available modes of hydrogen production. However, the current regulation of hydrogen does not adhere to the principle of technological neutrality, which creates a risk of path dependency and may stifle innovation in the future.
Towards a Sustainable, Integrated, and Decarbonized Energy System in the EU: Addressing Structural Challenges Through Hydrogen System Planning
Authors: Jiménez Casanova Paola 
Published: December 2024

Abstract
The development of the hydrogen system in the EU is part of a larger strategy to transition into an integrated, sustainable, and decarbonized energy system. This article argues that two crises that the EU is facing, the first environmental and climatic and the second revolving around security of supply, are influencing the planning of the hydrogen system. These crises have increased the urgency with which the EU seeks to make the energy sector sustainable and to bolster energy security in the region. However, the implementation of the internal market for hydrogen is liable to run into several challenges. This article focuses on Hydrogen System Planning and the challenges that the EU Hydrogen Backbone may face from a regulatory perspective. The EU institutions and the Member States must confront those challenges as robustly as possible if they are to avoid hindering the development of an integrated, carbon-neutral, and sustainable hydrogen system.