bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photochemical Transformations with Iodine Azide after Release from an Ion‐Exchange Resin
Authors: Kösel Teresa , Schulz Göran , Dräger Gerald , Kirschning Andreas 
Published: March 2020

AbstractThis report discloses the photochemical homolytic cleavage of iodine azide after its formation following release from polymer‐bound bisazido iodate(I) anions. A series of radical reactions are reported including the 1,2‐functionlization of alkenes and the unprecedented chemoselective oxidation of secondary alcohols in the presence of primary alcohols.
A novel bidentate ligand containing oxime, hydrazone and indole moieties and its BF2+ bridged transition metal complexes and their efficiency against prostate and breast cancer cells
Authors: Babahan Ilknur , Özmen Ali , Aksel Mehran , Bilgin Mehmet Dincer , Gumusada Rukiye , Gunay Muhammet Emin , Eyduran Fatih 
Published: March 2020

AbstractIn this study, a novel bidentate ligand containing oxime, hydrazone, and indole moieties and its BF2+‐bridged transition metal complexes [Ni(II), Cu(II), and Co(II)] were synthesized and their cytotoxic activities against prostate and breast cancer cells were investigated. The vic‐dioxime ligand bearing indole–hydrazone side groups was synthesized by reacting antiglyoximehydrazine (GH2) with 3‐methoxy indole. The ligand forms mononuclear complexes with a metal‐to‐ligand ratio of 1:2 with M = Co(II)(H2O)2, Ni(II), and Cu(II). These metal complexes were then reacted with BF3(C2H5)2O to obtain BF2+‐bridged transition metal complexes. The Co(II) complex of the ligand is proposed to be octahedral with water molecules as axial ligands, whereas the Ni(II) and Cu(II) complexes are proposed to be square planar. Spectral studies showed that the ligand bonded to the metal ion in a neutral bidentate fashion through the azomethine nitrogen atom and the imine oxime group. Structural assignments are supported by a combination of 1H nuclear magnetic resonance (NMR), 13C NMR, Fourier‐transform infrared, LC/MS, elemental analyses, and magnetic susceptibility testing. For determining the cytotoxic effects of the novel anticancer products, cancer cells were cultured. The antiproliferative effects were determined using the MCF‐7 breast cancer and PC‐3 prostate cancer cell lines. The antiproliferative effects of the products were analyzed and their apoptotic or necrotic effects were determined with the Hoechst/propidium iodide double staining method in both cancer cell lines. Paclitaxel was used as the positive control (1 μm). The results indicated that the newly synthesized compounds are effective on both cell lines between concentrations of 5 and 40 μm and show their effects by apoptotic mechanisms. Besides, these products were found to be more effective on the MCF‐7 cell line. The cytotoxic efficiency of the newly synthesized products was more than that of paclitaxel (depending on concentration), which is a chemotherapeutic agent used in cancer therapy.
Comparing the performance of low‐grade nickel ore and limestone for treatment of synthetic acid mine drainage
Authors: Turingan Casey Oliver A. , Fabella Divina Joyce A. , Sadol Kim Ahmed N. , Beltran Arnel B. , Alorro Richard D. , Orbecido Aileen H. 
Published: March 2020

AbstractGoethite is a dominant component of nickel laterite ores, which is capable of adsorbing metal ions in water. The potential of the unused low‐grade nickel ore (LGO) to treat synthetic acid mine drainage (AMD) was investigated. LGO characterization identified the presence of goethite (α‐FeOOH), calcium oxide (CaO), and manganese aluminum oxide. The performance of LGO for AMD treatment was evaluated using jar test and compared with limestone. At 0.5 ml AMD/g media, LGO increased the pH of AMD to 5.36 while limestone completely neutralized it. LGO removed more than 99% of Al and Fe, 94% of Ni, and 93% of sulfates compared to a 70% sulfate removal using limestone. The lower sulfate removal may be due to the armouring of the limestone surface. Furthermore, a batch test was conducted using both LGO and limestone as layered treatment media in an oxic and anoxic setup. Effluent pH remained constant while conductivity and TDS stabilize at 2,000 μS/cm and 1,000 ppm, respectively. Both setups achieved 99% removal of Fe and Al, ~90% Ni removal, and between 70% and 80% sulfate removal. These results indicate that LGO is a possible alternative material to be used for heavy metal adsorption for AMD treatment.
Stratified microbial structure and activity within anode biofilm during electrochemically assisted brewery wastewater treatment
Authors: Mai Qijun , Yang Guiqin , Cao Jiayao , Zhang Xia , Zhuang Li 
Published: March 2020

AbstractIn a bioelectrochemical system (BES), microbial community of anode biofilm is crucial to BES performance. In this study, the stratified pattern of community structure and activity of an anode‐respiring biofilm in a BES fueled with brewery wastewater was investigated over time. The anode biofilm exhibited a superior performance in the removal of ethanol to that of an open‐circuit system. The electrical current density reached a high level of 0.55mA/cm2 with a Coulombic efficiency of 71.4%, but decreased to 0.18mA/cm2 in the late stage of operation. A mature biofilm developed a more active outer layer covering a less active inner core, although the activities of the outer and inner layers of biofilm were similar in the early stage. More Geobacter spp., typical exoelectrogens, were enriched in the outer layer than in the inner layer of biofilm in the early stage, while more Geobacter spp. were distributed in the inner layer than in the outer layer in the late stage. The inactive and Geobacter‐occupied inner layer of biofilm might be responsible for the decreased electricity generation from wastewater in the late stage of operation. This study provides better understanding of the effect of anode biofilm structure on BES performance.
The relationship between sexual activity and sexual attitudes among breast cancer survivors in China
Authors: Yan Rui , Yu Jinming , Tanimoto Tetsuya , Ozaki Akihhiko , Lu Xinyuan , Che Beibei , Zhang Yaxuan , Chen Panzhen , Wang Jiwei 
Published: March 2020

AbstractPurposeLess is known about sexual attitudes of breast cancer survivors (BCSs) and its association with sexual activity and sexual dissatisfaction.MethodsWe investigated the proportion of sexual activity and sexual dissatisfaction in a cross‐sectional study among 341 Chinese BCSs aged 30‐75 years old, and we described their association with sexual attitudes, as well as socio‐demographic characteristics, physical health conditions, and mental health problems.ResultsOnly 83 (24.3%) individuals reported sexual activity in the past year. More than 50% of BCSs considered that sexual activity had adverse impact on their disease recovery. The sexual attitudes such as “sexual activity may impede disease recovery” (adjusted odds ratio [AOR] = 0.51; 95% confidence interval, 95% CI: 0.30‐0.88), “sexual activity may cause cancer recurrence or metastasizes” (AOR = 0.51; 95% CI: 0.30‐0.87), and “their partner fear contracting cancer by sexuality” (AOR = 0.47; 95% CI: 0.23‐0.98) were significantly associated with decreased likelihood of reporting sexual activity in the past year. Although 201 (58.9%) BCSs reported that breast cancer decreased the frequency of their sexual activity, only 37 (10.9%) had ever discussed sexuality with a doctor to seek advice.ConclusionsMost Chinese BCSs were sexually inactive. The sexual misconceptions about cancer were great barriers of sexual activity. Professional sexual education and consultation may be regarded as easy and effective intervention measures to correct BCSs' misguided sexual attitudes, and finally improving the overall sexual health for BCSs.
Metabolites from Two Dominant Thermophilic Fungal Species Thermomyces lanuginosus and Scytalidium thermophilum
Authors: Yang Xiao‐Yu , Zhang Jun‐Xian , Ding Qiu‐Yan , He Zi‐Cong , Zhu Chun‐Yan , Zhang Ke‐Qin , Niu Xue‐Mei 
Published: March 2020

AbstractThermomyces lanuginosus and Scytalidium thermophilum are among the most ubiquitous thermophilic fungi in compost and soil. Chemical study on these two prevalent strains collected from Yunnan led to isolation of 23 metabolites, including one new metabolite, therlanubutanolide, and 15 known compounds, isolated from the YGP culture broth of Thermomyces lanuginosus and 7 known compounds isolated from Scytalidium thermophilum, respectively. Therlanubutanolide shared the quite similar features of the same carbon skeleton and saturation as natural hexadecanoic acids. This was the first reported discovery of such a lactone as natural occurring metabolite. All the compounds were reported for the first time from thermophilic fungi. Among them, N‐[(2S,3R,4E,8E)‐1,3‐dihydroxy‐9‐methyloctadeca‐4,8‐dien‐2‐yl]acetamide was for the first time reported to be a naturally occurring metabolite and its NMR data was first provided in this study. A type of PKS‐derived metabolites, three 3,4‐dihydronaphthalen‐1(2H)‐ones, which were widely found in plant pathogenic fungi as phytotoxins and reported to have antimicrobial activity, were obtained from both dominant thermophilic fungi. The frequent occurrence of such PKS phytotoxins in these two thermophilic fungi might suggest particular ecological interest.
Ubiquitin carboxy‐terminal hydrolase L1 – physiology and pathology
Authors: Matuszczak Ewa , Tylicka Marzena , Komarowska Marta Diana , Debek Wojciech , Hermanowicz Adam 
Published: March 2020

AbstractUbiquitin C‐terminal hydrolase 1 (UCHL1) is an enzyme unique for its multiple activity – both ligase and hydrolase. UCHL1 was first identified as an abundant protein found in the brain and testes, however its expression is not limited to the neuronal compartment. UCHL1 is also highly expressed in carcinomas of various tissue origins, including those from brain, lung, breast, kidney, colon, prostate, pancreas and mesenchymal tissues. Loss‐of‐function studies and an inhibitor for UCHL1 confirmed the importance of UCHL1 for cancer therapy. So far biological significance of UCHL1 was described in the following processes: spermatogenesis, oncogenesis, angiogenesis, cell proliferation and differentiation in skeletal muscle, inflammation, tissue injury, neuronal injury and neurodegeneration.
Mechanistic Investigation of Photochemical Reactions by Mass Spectrometry
Authors: Zelenka Jan , Roithová Jana 
Published: March 2020

AbstractThis Minireview highlights the application of electrospray ionization mass spectrometry (ESI‐MS) to investigating photochemical reactions. We show possible approaches to on‐line ESI‐MS monitoring of photocatalytic reactions and give examples of the characterization of short‐lived photochemical intermediates by ion spectroscopy. The minireview also exemplifies in‐depth mass spectrometric studies of photoisomerization reactions and photofragmentation reactions. Apart from mechanistic studies, the coupling of photochemistry and mass spectrometry is a powerful approach to studying structure and properties of biomolecules. We show several examples focused on investigation of intrinsic properties of model biomolecules.
Novel volumetric analysis for stent expansion after drug‐eluting stent implantation: An optical coherence tomography study
Authors: Katsura Aritomo , Minami Yoshiyasu , Kato Ayami , Muramatsu Yusuke , Sato Toshimitsu , Hashimoto Takuya , Meguro Kentaro , Shimohama Takao , Ako Junya 
Published: March 2020

AbstractObjectivesTo assess the clinical significance of a novel optical coherence tomography (OCT)‐derived volumetric parameter of stent expansion by comparing it with the conventional parameters in real‐world practice.BackgroundThe clinical significance of novel parameters in real‐world practice including longer and smaller stents remains to be elucidated.MethodsA total of 226 de novo lesion treated with drug‐eluting stents in 208 consecutive patients were enrolled. Stent expansion was retrospectively assessed on the final OCT images after stent implantation. The novel parameter was the minimum expansion index (MEI) calculated using a novel algorithm that yields the ideal lumen area in each frame by taking into account vessel tapering. The device‐oriented clinical end point (DoCE) included cardiac death, target vessel‐related myocardial infarction, ischemia‐driven target lesion revascularization.ResultsThe MEI in the lesions with a DoCE (n = 22) at 2 years and cases without a DoCE (n = 204) was 64.3 ± 12.0% and 78.5 ± 14.6%, respectively (p < .001). In the receiver operating characteristic curve analyses, the areas under the curve for the MEI (0.787; p < .001) were larger than that for %stent expansion (0.718; p = .001) and minimum stent area (0.664; p = .004) in predicting the DoCE. The best cutoff of MEI for predicting the DoCE was 74.0.ConclusionsThe novel MEI was better than the conventional %stent expansion and minimum stent area for predicting DoCE.
Surface Assembling of Highly Interconnected and Vertically Aligned Porous Nanosheets of Gd−CoB on TiO2 Nanoflowers for Durable Methanol oxidation Reaction
Authors: ul Haq Tanveer , Bicer Yusuf , Munir Akhtar , Mansour Said A. , Haik Yousef 
Published: March 2020

AbstractBeing a green and carbon‐neutral technology, direct methanol fuel cell (DMFC) has attracted much attention while endowing highest mass energy density at low operating temperature. However, the multistep and multielectron process of methanol oxidation reaction (MOR) taking place at the anodic side in DMFC is an energy intense process. In addition, the in situ generated CO can severely deteriorate the catalytic efficiency of electrode material, which can be, however, realized to develop a competent catalytic module. Here, we present a first report on a highly interconnected and facile growth of vertically aligned Gd doped CoB assembled on the surface of rationally developed TiO2 nanoflower (NFs) for MOR. Initially, we developed the TiO2 NFs as support followed by cathodic deposition of Gd−CoO to create an electronic contact with underlying support. After then, finally treated with NaBH4 to further modify the surface of overall hybrid material, characterized with various techniques (UPS, XPS, XRD, SEM, TEM, Raman, and BET analyzer). During electrocatalysis, Gd−CoB@TiO2 was found highly efficient with inherently low charge transfer resistance (Rct) and ability to generate highest current density (400 mA/cm2) with negligible loss in activity even after long term stability (20 h) while using highly concentrated methanol. Meanwhile, the surface modification with B, extended and highly interconnected nature of amorphous and promisingly mesoporous nanosheets in 3D manner further ameliorate the available surface for catalysis. In comparison with analogues samples and literature, it is anticipated that Gd could modify the electronic structure of overall hybrid in such way to energize the redox couple of Co+2/+3 in Gd−CoB against the CO poisoning effect. Further, the XPS and Raman analysis before and after catalysis also indicates that in‐situ generated oxide/hydroxide formation with high inherent polarizability weaken the C−O−H bond of methanol and thus facilitate the dynamic release of involved intermediates.
Extracellular Matrix Proteins Involved in Alzheimer's Disease
Authors: Ma Jun , Ma Chao , Li Jingjing , Sun Yao , Ye Fangfu , Liu Kai , Zhang Hongjie 
Published: March 2020

AbstractAlzheimer's disease (AD) is one of the most common neurodegenerative diseases and characterized by cognitive and memory impairments. Emerging evidence suggests that the extracellular matrix (ECM) in the brain plays an important role in the etiology of AD. It has been detected that the levels of ECM proteins have changed in the brains of AD patients and animal models. Some ECM components, for example, elastin and heparan sulfate proteoglycans, are considered to promote the upregulation of extracellular amyloid‐beta (Aβ) proteins. In addition, collagen VI and laminin are shown to have interactions with Aβ peptides, which might lead to the clearance of those peptides. Thus, ECM proteins are involved in both amyloidosis and neuroprotection in the AD process. However, the molecular mechanism of neuronal ECM proteins on the pathophysiology of AD remains elusive. More investigation of ECM proteins with AD pathogenesis is needed, and this may lead to novel therapeutic strategies and biomarkers for AD.
Investigation of reaction condition effects on photocatalytic methane production over P25‐TiO2/Pt with CO2 and H2O gas. Applied and mechanistic implications
Authors: Molins Francesc , Küpper Karsten , Schweers Elke 
Published: March 2020

AbstractThe photocatalytic activity of P25 TiO2 with 0.36 % (w/w) Pt co‐catalyst towards the formation of methane, in the presence of CO2 and H2O vapor, is investigated in a flow photoreactor under varying reaction conditions of temperature, water molar fraction in the dosed gas and residence time. Within the range of parameters studied, H2O molar fraction is found to be the most sensitive parameter, and its increase leads to larger production rates as well as to a significant slow down of photocatalytic activity loss. This observed activation with water content is in contrast to the effect known in neat P25 and it occurs in a regime of very large adsorbed H2O to CO2 excess, and can be understood in the context of hole extraction being much slower than electron extraction. These results also constrain the possible interpretation of the nature of the photocatalyst deactivation processes.
A Cerium Hexacyanoferrate (III) Nanoparticle‐modified Carbon Paste Electrode: Voltammetric Characterization and Behavior in the Presence of Dopamine
Authors: de Oliveira Denys Ribeiro , Fernandes Daniela Silvestrini , do Carmo Devaney Ribeiro 
Published: March 2020

AbstractThis study describes a fast and simple methodology for the preparation of Cerium (III) Hexacyanoferrate (II) (CeHCF) nanoparticles (NPs). The NPs were characterized by fourier transform infrared (FTIR), x‐ray diffraction (XRD), scanning electron microscopy (SEM) and cyclic voltammetry (CV). The CeHCF cyclic voltammogram indicate a well‐defined redox pair assigned as Fe2+/Fe3+ in the presence of cerium (III), with a formal potential of Eθ′=0.29 V (v=100 mV s−1, KNO3; 1.0 mol/L, pH 7.0). The carbon paste electrode modified with CeHCF (CeHCF‐CPE) was applied to the catalytic electrooxidation of dopamine applying Differential Pulse Voltammetry (DPV). DPV showed linear response at two concentration ranges, from 9.0×10−7 to 8.0×10−6 and 9.0×10−6 to 1.0×10−4 mol/L, with an LOD of 1.9×10−7 and 1.0×10−5 mol/L, respectively. The CeHCF‐CPE exhibited selectivity against substances commonly found in biological samples, with redox potentials close to that of dopamine, such as urea and ascorbic acid (AA). Subsequently the CeHCF‐CPE was successfully applied to the detection of dopamine in simulated urine samples, with recovery percentages ranging between 99 and 103%.
Biological activity of cerium dioxide nanoparticles
Authors: Sarnatskaya Veronika , Shlapa Yuliia , Yushko Larysa , Shton Irina , Solopan Sergii , Ostrovska Galyna , Kalachniuk Liliia , Negelia Anatolii , Garmanchuk Liudmyla , Prokopenko Igor , Khudenko Natalya , Maslenny Vitaly , Bubnovskaya Larysa , Belous Anatolii , Nikolaev Vladimir 
Published: March 2020

AbstractCerium dioxide nanoparticles (CeO2NPs) with a high value of ζ‐potential (≥30 mV) have been synthesized in reverse microemulsions and they are able to form the high‐stable aqueous suspension without any additional stabilizers. It has been shown that the interaction of such CeO2 NPs with transport proteins, such as BSA, affects their molecular conformation and biochemical activity. The observed changes in the UV‐absorbance spectrum and intrinsic fluorescence quenching of BSA molecule are indicative of the occurrence of structural changes caused by binding with the surface of CeO2NPs. Low affinity between BSA and CeO2 NPs has been confirmed by differential scanning calorimetry (DSC). Moreover, CeO2NPs can act as regenerative free‐radical scavengers, and their antioxidant activity depends on the concentration. The positive charge of CeO2NPs can be attributed to their low toxicity toward human malignant lymphocytes MT‐4 and breast cancer cells MCF‐7 however, the morphofunctional features of MCF‐7 cells interacting with CeO2NPs are indicative of the decrease in oncogenicity.
LncRNA H19 gene rs2839698 polymorphism is associated with a decreased risk of colorectal cancer in a Chinese Han population: A case‐control study
Authors: Yu Bingqu , Chen Jiayuan , Hou Chenfeng , Zhang Lei , Jia Jie 
Published: March 2020

AbstractBackgroundLong non‐coding RNA (lncRNA) H19 is involved in the carcinogenesis, progression, and metastasis of colorectal cancer (CRC). Recently, a few studies explored the relationship between lncRNA H19 gene rs2839698 polymorphism and CRC risk, but with conflicting findings.Materials and methodsA case‐control study with 315 CRC cases and 441 controls was designed in a Chinese population. Genotyping was performed using PCR‐RFLP.ResultsIt was found rs2839698 polymorphism was associated with a decreased risk of CRC (AA vs GG: OR, 0.73; 95% CI, 0.54‐0.98; P = .037; A vs G: OR, 0.78; 95% CI, 0.63‐0.96; P = .021). Stratified analyses indicated this positive association was also significant in the non‐smokers (AA vs GG: OR, 0.49; 95% CI, 0.25‐0.93; P = .029), non‐drinkers, those aged ≥ 60 years, and overweight individuals (BMI ≥ 24). In addition, rs2839698 polymorphism was also related to the lymph node metastasis (AA vs GG: OR, 0.43; 95% CI, 0.21‐0.88; P = .019) and tumor size (AA vs GG: OR, 0.42; 95% CI, 0.20‐0.88; P = .020) for patients with CRC.ConclusionTo sum up, the lncRNA H19 gene rs2839698 polymorphism decreases the risk of CRC in Chinese individuals, especially among the non‐smokers, non‐drinkers, individuals aged ≥ 60 years, and overweight individuals (BMI ≥ 24). Thus, the lncRNA H19 gene rs2839698 polymorphism might be an important biomarker and diagnostic marker for predicting the susceptibility to CRC in Chinese Han population.