bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural Modification Orientated Multifunctional AIE Fluorescence Probes: Organelles Imaging and Effective Photosensitizer for Photodynamic Therapy
Authors: Chen Kongqi , Zhang Rongyuan , Wang Zhiming , Zhang Weijie , Tang Ben Zhong 
Published: November 2019

AbstractLuminogens with aggregation‐induced emission feature (AIEgens) are highly demanded because of its excellent performance in fluorescent bioprobes. In this work, three AIEgens based on tetraphenylethylene isoquinolinium (TPE‐IQ) derivatives by introducing different electron donor and sterically hindered groups to replace the phenyl ring of the isoquinolinium core are prepared in a one‐pot reaction with a high yield and characterized systematically. By the analysis of photophysical properties and theoretical calculations, the structure‐property relationships among them become clear. Although they all inherit AIE feature as expected, these similar structural AIEgens present different organelle‐targets, which is attributed to their different cellular uptake way and energy barrier to cell membrane by detailed experiments. In addition, these TPE‐IQ‐based AIEgens are potential candidates for photodynamic therapy originating from their activities of generating reactive oxygen species under visible light irradiation.
Copper‐Catalyzed Domino Cyclization/Thiocyanation of Unactivated Olefins: Access to SCN‐Containing Pyrazolines
Authors: Meng Fei , Zhang Honglin , He Han , Xu Ning , Fang Qin , Guo Kang , Cao Shujun , Shi Yun , Zhu Yingguang 
Published: November 2019

AbstractA mild and highly efficient Cu‐catalyzed cascade cyclization/thiocyanation of unactivated alkenes bearing hydrazones has been developed. A broad range of SCN‐substituted pyrazolines have been readily obtained in good to excellent yields with commercially available and very cheap Cu(acac)2 and NH4SCN. This present method provides a rapid, facile, and practical access to valuable pyrazolines with the important SCN functionality, and it is amenable to the gram scale.magnified image
Resistance Drift Suppression Utilizing GeTe/Sb2Te3 Superlattice‐Like Phase‐Change Materials
Authors: Zhou Lingjun , Yang Zhe , Wang Xiaojie , Qian Hang , Xu Ming , Cheng Xiaomin , Tong Hao , Miao Xiangshui 
Published: November 2019

AbstractResistance drift is one of the key challenges in phase‐change memory, especially in multilevel storage applications. Although many efforts have been proposed to reduce the probability error caused by resistance drift, the most effective method to suppress resistance drift is by material design. Since resistance drift in amorphous materials comes from changes in the distributions of defects and tail states that are caused by spontaneous structural relaxation, it is possible to suppress resistance drift by confine defect relaxation. A superlattice‐like structure is used to construct relatively controllable interfaces different from those inherent in amorphous chalcogenide for the regulation of resistance drift. By adjusting structural parameters, amorphous GeTe/Sb2Te3 achieves a very low resistance drift. A low‐field electrical transport test based on a trapping band model shows that a change in the structural parameters directly affects the transport process in GeTe/Sb2Te3 such that the resistance drift is suppressed. X‐ray photoelectron spectroscopy characterization reveals that defects at interfaces in superlattice‐like GeTe/Sb2Te3 vary with the structural parameters. Compared with traditional doping and other methods, the interfacial structure introduces controllable defects and provides another strategy for the design of multilevel data storage.
Ionic Liquid Gating Control of Spin Wave Resonance in La0.7Sr0.3MnO3 Thin Film
Authors: Zhao Shishun , Hou Weixiao , Zhou Ziyao , Li Yaojin , Zhu Mingmin , Li Haobo , Li Chunlei , Hu Zhongqiang , Yu Pu , Liu Ming 
Published: November 2019

AbstractMagnonics or spin waves have the potential to serve as the carrier for future information communication. A controllable spin wave resonance (SWR) device is demonstrated in a Au/[DEME]+[TFSI]−/LSMO/STO capacitor heterostructure, which could be regulated by ionic liquid gating (ILG) method. The SWR critical angle φC, excitation position to perform uniform precession, is shifted in a reversible manner (thus recording “off” and “on”) with +1.5 V gating voltage (Vg), measured by quantitative angular dependent electron spin resonance (ESR) spectroscopy. Based on the modified Puszkarski's surface inhomogeneity model, the ILG control SWR at low Vg (Vg < 1.5 V) can be explained by a charge‐doping‐induced effective surface magnetic anisotropy change. Applying a higher Vg (Vg > 1.5 V) enhances the surface mode SWR and gradually diminishes the body mode SWR. Oxygen vacancies generate at higher Vg (Vg > 1.5 V) resulting in the modulation of superexchange between the Mn ions, evidenced by X‐ray photoelectron spectroscopy and secondary ion mass spectroscopy characterization. This ILG control SWR presents a solution for energy efficient and low‐voltage control of magnonics and spin wave devices.
Amalgamation in action: Participant perspectives on the Armidale regional council merger process
Authors: Wallace Andrea , Dollery Brian , Thi Thanh Tran Carolyn-Dung 
Published: November 2019

AbstractUnder itsFit for the Futurereform programme, in May 2016 the New South Wales (NSW) government forcibly merged a number of municipalities, including the Armidale Dumaresq Council and the Guyra Shire Council in the New England region of northern NSW. Whilst scholarly attention has focused on the likely impact of municipal mergers on council performance at the system‐wide level (Bell, Dollery & Drew 2016; Economic Papers: A journal of applied economics and policy, 35, 99), much less effort has been devoted to the analysis of the perspectives of council managers and employees involved in forced consolidation. In order to address this gap in the literature, in this paper we present a case study of compulsory council consolidation of the Armidale and Guyra councils based on interviews with senior managers as well as a survey of council workers.
Homoleptic Ti[ONO]2 type complexes of amino‐acid‐tethered phenolato Schiff‐base ligands: Synthesis, characterization, time‐resolved fluorescence spectroscopy, and cytotoxicity against ovarian and colon cancer cells
Authors: Shpilt Zohar , Manne Rajesh , Rohman Mostofa Ataur , Mitra Sivaprasad , Tiekink Edward R.T. , Basu Baul Tushar S. , Tshuva Edit Y. 
Published: November 2019

Six homoleptic Ti (IV) compounds of dianionic tridentate ONO Schiff base ligands with various substitutions were prepared from chiral amino acids, 2‐hydroxybenzaldehyde, which were generated in situ, and Ti (OiPr)4. The compounds were spectroscopically characterized and the molecular geometries of five complexes were established by X‐ray crystallography; for two structures, two independent molecules compose the asymmetric units. The di‐anionic, tridentate ligands coordinate the titanium centers via the carboxylate‐O‐, imine‐N‐ and phenoxide‐O atoms to form five‐ and six‐membered chelate rings. The molecules are based on a trans‐N2O4 donor with each carboxylate‐O atom trans to a phenoxide‐O atom. For the smallest derivative with Me substitution, racemization occurs during repeated recrystallization. Photophysical profiles of the titanium compounds in the solid phase and in solution are discussed. Marked cytotoxicities were recorded toward human ovarian A2780 and colon HT‐29 cancer cells with IC50 values ranging between 23 ± 2 and 103 ± 3 μM. Comparative hydrolytic stability of the complexes were studied by NMR in 10% D2O solutions which provided t1/2 values of up to 15 ± 2 hr.
Polymer nanocarriers for MicroRNA delivery
Authors: Kapadia Chintan H. , Luo Benjamin , Dang Megan N. , Irvin‐Choy N'Dea , Valcourt Danielle M. , Day Emily S. 
Published: November 2019

ABSTRACTAbnormal expression of microRNAs (miRNAs), which are highlyconserved noncoding RNAs that regulate the expression of various genes post transcriptionally to control cellular functions, has been associated with the development of many diseases. In some cases, disease‐promoting miRNAs are upregulated, while in other instances disease‐suppressive miRNAs are downregulated. To alleviate this imbalanced miRNA expression, either antagomiRs or miRNA mimics can be delivered to cells to inhibit or promote miRNA expression, respectively. Unfortunately, the clinical translation of bare antagomiRs and miRNA mimics has been challenging because nucleic acids are susceptible to nuclease degradation, display unfavorable pharmacokinetics, and cannot passively enter cells. This review emphasizes the challenges associated with miRNA mimic delivery and then discusses the design and implementation of polymer nanocarriers to overcome these challenges. Preclinical efforts are summarized, and a forward‐looking perspective on the future clinical translation of polymer nanomaterials as miRNA delivery vehicles is provided. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48651.
Taxonomic status, biological notes, and conservation of the longhorned pygmy devil ray Mobula eregoodoo (Cantor, 1849)
Authors: Notarbartolo di Sciara Giuseppe , Adnet Sylvain , Bennett Mike , Broadhurst Matt K. , Fernando Daniel , Jabado Rima W. , Laglbauer Betty J.L. , Stevens Guy 
Published: November 2019

Abstract

The longhorned pygmy devil ray Mobula eregoodoo (Cantor, 1849), formerly known as Mobula eregoodootenkee (Bleeker, 1859), is a small mobulid with a disc reaching a maximum width of 1.3 m, widely ranging in tropical and subtropical latitudes across the Indian Ocean, the Indo‐Pacific region, and the western Pacific Ocean.
A recently emerged opportunity to examine several (n = 47) M. eregoodoo specimens bycaught in bather protection gillnets off New South Wales, Australia, together with new information assembled from other areas of its range, now allows for a redescription of the species, which was incompletely described in the past because of a paucity of specimens.
Based on the morphometric, morphological, ecological, and behavioural elements presented here, corroborated by recent genetic investigations, we argue that M. eregoodoo (Cantor, 1849) is a valid species, distinct from shorthorned pygmy devil ray Mobula kuhlii (Müller & Henle, 1841). These findings are contrary to a recent revision of Mobula, where it was assessed as a synonym of M. kuhlii.
The accuracy of taxonomic assessments underpins the effectiveness of species conservation, particularly when direct exploitation or bycatch in various fisheries needs to be managed for sustainability. Failing to recognize that two similar‐looking species are distinct, such as M. eregoodoo and M. kuhlii, creates uncertainties that could result in mismanagement and underestimating local and global threats of extinction.
Direct Metal‐Free Chemical Vapor Deposition of Graphene Films on Insulating Substrates for Micro‐Supercapacitors with High Volumetric Capacitance
Authors: Wuttke Michael , Liu Zhaoyang , Lu Hao , Narita Akimitsu , Müllen Klaus 
Published: November 2019

AbstractInvited for this month's cover picture is the group of Prof. Dr. Klaus Müllen. The cover picture shows the direct metal‐free chemical vapor deposition of graphene films on insulating substrates and their integration into high‐volumetric capacitive micro‐supercapacitors. Read the full text of the Article at 10.1002/batt.201900087
Photophysical and structural aspects of perylene‐doped 2‐naphthol luminophors: Green emission by exciplex formation
Authors: Mane K.G. , Nagore P.B. , Pujari S.R. 
Published: November 2019

AbstractSeveral perylene (Pery)‐doped 2‐naphthol (2‐NP) (Pery/2‐NP) luminophors were prepared using conventional solid‐state reaction techniques. Energy transfer in the excited state was examined using fluorescence spectroscopy and cyclic voltammetry. Fluorescence studies revealed exciplex formation by Pery in the form of structureless and broad spectra at higher concentrations with monomer quenching of 2‐NP; a broad green emission was observed in the range 500–650 nm, peaking at 575 nm. Structural properties and thermal stability were analyzed using X‐ray diffraction, scanning electron microscopy and TGA‐differential scanning calorimetry. Highest occupied molecular orbital and lowest unoccupied molecular orbital energy levels were observed in the range 5.56–5.61 eV and 2.79–2.81 eV, respectively with a 2.77–2.82 eV band gap. The present study reveals these to be probable candidates for hole‐transporting materials suitable in optoelectronics.
Treatment of advanced gallbladder cancer: A SEER‐based study
Authors: Mao Weipu , Deng Fang , Wang Dongyan , Gao Li , Shi Xiuquan 
Published: November 2019

AbstractPurposeThe treatment of advanced gallbladder cancer (GBC) remains controversial. Therefore, the purpose of this study was to explore treatment choices for advanced GBC.MethodsWe identified four different treatments from the surveillance, epidemiology, and end results (SEER) database: surgery, chemotherapy (CT), surgery and chemotherapy (Surgery + CT), and no surgery/no chemotherapy (No surgery/No CT). Kaplan‐Meier method and Cox proportional hazards regression method were used to determine the risk factors for overall survival (OS) and cancer‐specific survival (CSS). In addition, patients in AJCC stages III and IV stage were matched with 1:1 propensity score matching (PSM) for diagnosis age, race, marital status, histological type, tumor grade, and treatment pattern to decrease the possibility of selection bias.ResultsA total of 288 AJCC stage III patients and 4239 AJCC stage IV patients with advanced GBC were identified from the SEER database between 2004 and 2015. Treatment pattern was an independent risk factor for patients with advanced GBC. For all patient, AJCC stage III patients and AJCC stage IV patients, “Surgery + CT” treatment minimized the OS and CSS in advanced GBC patients. In addition, after the PSM analysis, the “Surgery + CT” treatment still significantly decreased patient OS and CSS.Conclusions“Surgery + CT” treatment can provide survival benefits for patients with advanced GBC. In addition, “Surgery + CT” treatment was not fully utilized and may further improve the survival rate of GBC patients.
Impact of high on‐treatment platelet reactivity on outcomes following PCI in patients on hemodialysis: An ADAPT‐DES substudy
Authors: Rubin Geoffrey A. , Kirtane Ajay J. , Chen Shmuel , Redfors Björn , Weisz Giora , Baber Usman , Zhang Yiran , Stuckey Thomas D. , Witzenbichler Bernhard , Rinaldi Michael J. , Neumann Franz‐Josef , Metzger D. Christopher , Henry Timothy D. , Cox David A. , Duffy Peter L. , Brodie Bruce R. , Mazzaferri Ernest L. , Mehran Roxana , Ali Ziad A. , Ben‐Yehuda Ori , Stone Gregg W. 
Published: November 2019

AbstractOBJECTIVESWe sought to compare clinical outcomes after percutaneous coronary intervention (PCI) in patients on versus not on hemodialysis (HD) and examine whether high on‐treatment platelet reactivity (HPR) further impacts outcomes among patients on HD.BACKGROUNDBoth chronic kidney disease (CKD) and HPR are predictors of major adverse cardiac events (MACE) after PCI.METHODSTwo‐year outcomes of patients from the prospective, multicenter ADAPT‐DES study (N = 8,582) were analyzed according to HD status at enrollment. All patients underwent platelet function testing with the VerifyNow assay; HPR on clopidogrel was defined as P2Y12 reaction units (PRU) >208.RESULTSCompared with non‐HD patients, patients on HD (n = 85) had significantly higher baseline PRU (median 254 vs. 188, p = .001) and more frequently had HPR (61.7% vs. 42.5%, p < .001). HD was associated with increased 2‐year rates of MACE (death, myocardial infarction (MI) or definite stent thrombosis (ST); 23.4% vs. 10.7%, p < .001). HD was also strongly associated with 2‐year overall mortality, cardiac death, MI, target vessel revascularization, major bleeding, stroke and ST. Following adjustment for HPR and other covariates, HD was independently associated with overall mortality, MI, ST, and major bleeding at 2 years. The relationship between HD status and 2‐year MACE was consistent in patients with and without HPR (Pinteraction = .78).CONCLUSIONSNearly two‐thirds of patients on HD exhibited HPR on clopidogrel, and both HD and HPR were independently associated with 2‐year adverse outcomes after DES implantation. However, the deleterious impact of HD on clinical outcomes was present in both patients with and without HPR.
Recurrent soft tissue inflammation, necrotizing fascitis or Sweet syndrome, diagnostic dilemma
Authors: Anand Ankit , Gentile Teresa , Kato Hiroshi , Wang Qun 
Published: November 2019

AbstractNecrotizing Sweet syndrome is a recently described entity that can pose significant challenges for management. Although necrotizing fasciitis can be rapidly fatal in the absence of prompt surgical management, necrotizing Sweet syndrome may actually be worsened by any surgical intervention. Authors want to emphasize and increase awareness of this rare presentation.
Measuring cardiopulmonary complications of carfilzomib treatment and associated risk factors using the SEER‐Medicare database
Authors: Fakhri Bita , Fiala Mark A. , Shah Nina , Vij Ravi , Wildes Tanya M. 
Published: November 2019

BackgroundCarfilzomib improves survival in patients with recurrent myeloma. Given the strict eligibility criteria in clinical trials, the actual frequency of cardiac adverse events (CAEs) and pulmonary adverse events (PAEs) and the risk factors associated with these AEs in the general population need to be established.MethodsThe authors extracted myeloma cases in the Surveillance, Epidemiology, and End Results (SEER)–Medicare linked database from 2000 through 2013 and corresponding claims through 2014. They then identified patients who received carfilzomib during their disease course. Subsequently, the International Classification of Diseases, Ninth Revision (ICD‐9) was used to identify all the codes for CAEs, PAEs, and respiratory infections associated with carfilzomib use. Preexisting diagnoses corresponding to the CAEs and PAEs of interest were excluded to distinguish toxicity from comorbidity. Multivariate Cox regression was performed to determine those variables independently associated with the development of CAEs and PAEs.ResultsOf the 635 patients analyzed, the median age was 72 years (range, 36‐94 years); 55% of the patients were male and 79% were white. The median duration of carfilzomib treatment was 58 days (range, 1‐716 days). Overall, approximately 66% of the patients had codes for either CAEs or PAEs. In terms of CAEs, approximately 22% of patients developed hypertension, 15% developed peripheral edema, and 14% experienced heart failure. With regard to PAEs, approximately 28% of patients developed dyspnea, 15% developed cough, and 15% developed pneumonia. Only chronic obstructive pulmonary disease (COPD) was found to be independently associated with the development of CAEs. Patients with preexisting COPD were found to have a 40% increase in their hazard of developing CAEs (adjusted hazard ratio, 1.40; 95% CI, 1.03‐1.90).ConclusionsIn older adults with myeloma who are undergoing treatment with carfilzomib, new cardiac and pulmonary diagnoses were common. Patients with preexisting COPD were found to be at an increased risk of developing CAEs.
Histamine and histidine decarboxylase in the olfactory system and brain of the common cuttlefish Sepia officinalis (Linnaeus, 1758)
Authors: Scaros Alexia T. , Andouche Aude , Baratte Sébastien , Croll Roger P. 
Published: November 2019

AbstractCephalopods are radically different from any other invertebrate. Their molluscan heritage, innovative nervous system, and specialized behaviors create a unique blend of characteristics that are sometimes reminiscent of vertebrate features. For example, despite differences in the organization and development of their nervous systems, both vertebrates and cephalopods use many of the same neurotransmitters. One neurotransmitter, histamine (HA), has been well studied in both vertebrates and invertebrates, including molluscs. While HA was previously suggested to be present in the cephalopod central nervous system (CNS), Scaros, Croll, and Baratte only recently described the localization of HA in the olfactory system of the cuttlefish Sepia officinalis. Here, we describe the location of HA using an anti‐HA antibody and a probe for histidine decarboxylase (HDC), a synthetic enzyme for HA. We extended previous descriptions of HA in the olfactory organ, nerve, and lobe, and describe HDC staining in the same regions. We found HDC‐positive cell populations throughout the CNS, including the optic gland and the peduncle, optic, dorso‐lateral, basal, subvertical, frontal, magnocellular, and buccal lobes. The distribution of HA in the olfactory system of S. officinalis is similar to the presence of HA in the chemosensory organs of gastropods but is different than the sensory systems in vertebrates or arthropods. However, HA's widespread abundance throughout the rest of the CNS of Sepia is a similarity shared with gastropods, vertebrates, and arthropods. Its widespread use with differing functions across Animalia provokes questions regarding the evolutionary history and adaptability of HA as a transmitter.
Afferent connections of the thalamic nucleus reuniens in the mouse
Authors: Scheel Niklas , Wulff Peer , de Mooij‐van Malsen Johanne G. 
Published: November 2019

AbstractThe nucleus reuniens (RE) is part of the midline thalamus and one of the major sources of thalamic inputs to the hippocampal formation and the medial prefrontal cortex. However, it not only sends strong efferents to these areas but is also heavily innervated by both brain regions. Based on its connectivity and supported by functional studies the RE has been suggested to represent a major hub in reciprocal hippocampal–prefrontal communication. Indeed, inactivation studies have demonstrated that this nucleus is particularly important for cognitive behaviors which depend on prefrontal–hippocampal communication, such as working memory or memory consolidation. However, besides its central role in mediating hippocampal–prefrontal communication, the RE is target of a multitude of other cortical and subcortical afferents, which likely modulate its function. So far, however, studies that have systematically investigated the afferents of the RE have only been performed in rats. Because of the unique role of the mouse as a genetically accessible model system for mammalian brain circuit analysis we have mapped the afferent connectivity of the mouse RE using retrograde Fluoro‐Gold tracing. Comparison with similar data from rats indicated a very high level of similarity in prefrontal and hippocampal afferents but some differences in afferent connectivity with other brain regions. In particular, our results suggest interspecies differences regarding the integration of the RE in circuits of fear, aversion, and defense.
Hierarchical Roofline analysis for GPUs: Accelerating performance optimization for the NERSC‐9 Perlmutter system
Authors: Yang Charlene , Kurth Thorsten , Williams Samuel 
Published: November 2019

SummaryThe Roofline performance model provides an intuitive and insightful approach to identifying performance bottlenecks and guiding performance optimization. In preparation for the next‐generation supercomputer Perlmutter at NERSC, this paper presents a methodology to construct a hierarchical Roofline on NVIDIA GPUs and extends it to support reduced precision and Tensor Cores. The hierarchical Roofline incorporates L1, L2, device memory, and system memory bandwidths into one single figure, and it offers more profound insights into performance analysis than the traditional DRAM‐only Roofline. We use our Roofline methodology to analyze three proxy applications: GPP from BerkeleyGW, HPGMG from AMReX, and conv2d from TensorFlow. In doing so, we demonstrate the ability of our methodology to readily understand various aspects of performance and performance bottlenecks on NVIDIA GPUs and motivate code optimizations.