bluuebunny/crossref_metadata_2025_split huggingface dataset:
The examination of Van Gogh’s chrome yellow pigments in ‘Field with Irises near Arles’ using quantitative SEM–WDX
Authors: Geldof Muriel , van der Werf Inez Dorothé , Haswell Ralph 
Published: December 2019

Abstract
In this paper we present the results of quantitative measurements on the pigment chrome yellow (PbCr1−xSxO4 with 0 ≤ x ≤ 0.8) using scanning electron microscopy-wavelength dispersive X-ray analysis (SEM–WDX). Traditionally, Optical Microscopy (OM) in combination with scanning electron microscopy-energy dispersive X-ray analysis (SEM–EDX) is used for the identification of many pigments in paint cross-sections based on their particle characteristics and elemental composition. However, in the case of chrome yellow, the lead (Pb) and sulphur (S) peaks overlap, which makes quantitative analysis unreliable. SEM–WDX does not suffer from this problem and we have demonstrated that this technique can distinguish different types of chrome yellow based on the quantification of the sulphur-content of the pigment. This identification can be performed on paint cross-sections, allowing for distinction between chrome yellows in different paint layers. In addition, our study showed that the different types of chrome yellow can still be identified even in low concentrations. Van Gogh made wide use of different hues of chrome yellow. Using this method, we have identified the types of chrome yellow he used in Field with Irises near Arles, which we have been able to correlate with the information in his letters. Raman spectroscopy of the same samples confirmed the SEM–WDX results, but evidenced a higher sensitivity of the latter technique in revealing small amounts of sulphur-rich PbCr1−xSxO4 in mixtures with PbCrO4. SEM–WDX is also more accurate, because it allows the lead(II) sulphate fraction to be determined within 1 mol% absolute, whereas with Raman spectroscopy only relatively broad ranges can be defined. The on-going research of Van Gogh’s paintings as part of a cataloguing project—a collaboration between the Van Gogh Museum, the Cultural Heritage Agency of the Netherlands and Shell—opens the way for a comprehensive comparison of the chrome yellows used by Van Gogh using SEM–WDX.
Investigation on geothermal binary-flashing cycle employing zeotropic mixtures as working fluids
Authors: Wang Lingbao , Bu Xianbiao , Li Huashan 
Published: December 2019

AbstractThe binary-flashing cycle (BFC) is supposed to be a promising technology for geothermal recovery due to the full use of geofluid. For further performance improvement, the potential of using mixtures of a hydrocarbon and a retardant in the BFC system is investigated. R245fa is selected as a retardant and blended with R600 to form zeotropic mixtures. With the thermal efficiency (ηth), exergy efficiency (ηex), net power output per ton geofluid (PRW), and exergy destruction rate (Ed) as evaluation indexes, the flowsheet modeling and optimization are conducted to explore the optimal compositions and operating parameters. It is revealed the optimal mass fraction of R600/R245fa is 0.44/0.56, at which the flammability of R600 is suppressed, the global warming potential (GWP) of R245fa is reduced. The maximum ηex and PRW are higher than those of component fluids. The maximum Ed occurs in the heat exchanger, which should be optimized. The recommended generation pressures are 1200–1430, 1240–1480, 1220–1460, and 1170–1420 kPa, respectively, for R600 mass fraction of 0.2, 0.4, 0.6, and 0.8. In addition, the flashing temperature is also optimized. Although the mixtures do not always yield superior performance, it is still beneficial to apply the mixtures to the BFC system through systematic consideration of safety and environmental friendliness.
Translational applications of photopolymerizable hydrogels for cartilage repair
Authors: Meng Weikun , Gao Liang , Venkatesan Jagadeesh K. , Wang Guanglin , Madry Henning , Cucchiarini Magali 
Published: December 2019

AbstractBackgroundArticular cartilage lesions generated by trauma or osteoarthritis are the most common causes of pain and disability in patients.AbstractThe development of photopolymerizable hydrogels has allowed for significant advances in cartilage repair procedures. Such three-dimensional (3D) networks of polymers that carry large amounts of water can be created to resemble the physical characteristics of the articular cartilage and be delivered into ill-defined cartilage defects as a liquid solution prior to polymerization in vivo for perfect fit with the surrounding native tissue. These hydrogels offer an adapted environment to encapsulate and propagate regenerative cells in 3D cultures for cartilage repair. Among them, mesenchymal stem cells and chondrocytes may represent the most adapted sources for implantation. They also represent platforms to deliver therapeutic, biologically active factors that promote 3D cell differentiation and maintenance for in vivo repair.ConclusionThis review presents the benefits of photopolymerization of hydrogels and describes the photoinitiators and materials in current use for enhanced cartilage repair.
Methane and Inflammation - A Review (Fight Fire with Fire)
Authors: Poles Marietta Zita , Juhász László , Boros Mihály 
Published: December 2019

AbstractMammalian methanogenesis is regarded as an indicator of carbohydrate fermentation by anaerobic gastrointestinal flora. Once generated by microbes or released by a non-bacterial process, methane is generally considered to be biologically inactive. However, recent studies have provided evidence for methane bioactivity in various in vivo settings. The administration of methane either in gas form or solutions has been shown to have anti-inflammatory and neuroprotective effects in an array of experimental conditions, such as ischemia/reperfusion, endotoxemia and sepsis. It has also been demonstrated that exogenous methane influences the key regulatory mechanisms and cellular signalling pathways involved in oxidative and nitrosative stress responses. This review offers an insight into the latest findings on the multi-faceted organ protective activity of exogenous methane treatments with special emphasis on its versatile effects demonstrated in sepsis models.
Man or machine? Prospective comparison of the version 2018 EASL, LI-RADS criteria and a radiomics model to diagnose hepatocellular carcinoma
Authors: Jiang Hanyu , Liu Xijiao , Chen Jie , Wei Yi , Lee Jeong Min , Cao Likun , Wu Yuanan , Duan Ting , Li Xin , Ma Ling , Song Bin 
Published: December 2019

AbstractBackgroundThe Liver Imaging Reporting and Data System (LI-RADS) and European Association for the Study of the Liver (EASL) criteria are widely used for diagnosing hepatocellular carcinoma (HCC). Radiomics allows further quantitative tumor heterogeneity profiling. This study aimed to compare the diagnostic accuracies of the version 2018 (v2018) EASL, LI-RADS criteria and radiomics models for HCC in high-risk patients.MethodsEthical approval by the institutional review board and informed consent were obtained for this study. From July 2015 to September 2018, consecutive high-risk patients were enrolled in our tertiary care hospital and underwent gadoxetic acid-enhanced magnetic resonance (MR) imaging and subsequent hepatic surgery. We constructed a multi-sequence-based three-dimensional whole-tumor radiomics signature by least absolute shrinkage and selection operator model and multivariate logistic regression analysis. The diagnostic accuracies of the radiomics signature was validated in an independent cohort and compared with the EASL and LI-RADS criteria reviewed by two independent radiologists.ResultsTwo hundred twenty-nine pathologically confirmed nodules (173 HCCs, mean size: 5.74 ± 3.17 cm) in 211 patients were included. Among them, 201 patients (95%) were infected with hepatitis B virus (HBV). The sensitivity and specificity were 73 and 71% for the radiomics signature, 91 and 71% for the EASL criteria, and 86 and 82% for the LI-RADS criteria, respectively. The areas under the receiver operating characteristic curves (AUCs) of the radiomics signature (0.810), LI-RADS (0.841) and EASL criteria (0.811) were comparable.ConclusionsIn HBV-predominant high-risk patients, the multi-sequence-based MR radiomics signature, v2018 EASL and LI-RADS criteria demonstrated comparable overall accuracies for HCC.
Sustaining collaborative preschool partnerships and the challenges of educating the whole child
Authors: Alverson Ryan , Ginn Laken , Gilbert Jaesook 
Published: December 2019

Abstract
Introduction
Our study examined whole-child preschool programming from a policy perspective. We suggest that whole-child wellness must include sustainable approaches that are systematic and holistic approaches for educating children. The Preschool Partnership Grant was a means of funding preschool districts, who successfully applied for the grant across our state to initiate, continue, and sustain quality programming with their respective local preschool partners. Funding also enabled districts to increase access to quality programming while fostering kindergarten readiness in participating children.

Case description
We conducted a case study by analyzing data provided by district Preschool Partnership Grantees. Data included quantitative measures of district and partner preschools and open-ended items describing professional development opportunities, holistic interventions, and effective preschool activities afforded by grant funding.

Results
Grant recipients (n = 79) reported that they engaged in a number of different public and private partnerships. They reported being able to serve more children due to grant funding, and gave a variety of reasons for serving more children, with improved collaboration being the most reported reason. District grantees also indicated increased consultation, intervention services, and professional development opportunities through grant funding. Finally, they reported on key challenges they faced during the grant period.

Discussion and evaluation
Data suggested that school districts recognized the importance of collaboration, trust, and relationship building among districts, partners, and families. Descriptive data indicated the importance of sustaining quality programming during the grant period. Districts also clearly voiced their appreciation of the importance of relationships and collaboration among key stakeholders who touched the lives of children enrolled in the grantee districts.

Conclusions
Our study suggests that early childhood policy should enable systematic and sustainable partnerships that approach preschool programming from a holistic perspective.
Policy levers to promote cultural competence in early childhood programs in the USA: recommendations from system specialists
Authors: Porterfield Mary L. , Scott-Little Catherine 
Published: December 2019

AbstractThe purpose of the study was to investigate ways in which early childhood systems that rate and license child care programs, known as Quality Rating and Improvement Systems (QRISs), might incorporate requirements related to cultural competence into the system, including incentives, supports, and rewards for programs that foster cultural competence of the early care and education (ECE) workforce. The study employed a focus group design to consider the research problem from the vantage point of key informants such as coaches and other system staff who routinely support ECE programs to meet system requirements and to engage in quality improvement work. Three focus groups were convened, with a total ofN = 28 participants. The meetings were audio-recorded, transcribed, and analyzed using the constant comparative method. Emergent themes were noted and grouped into four categories: QRIS requirements; system alignment; ECE progrm administrator training; and ECE teacher training and technical assistance. Focus group members advocated for incorporation of system-level requirements related to cultural competence as well as program supports to ensure that ECE providers could succeed in meeting new requirements. Policy recommendations to support cultural competence development in the ECE workforce and to embed cultural competence in ECE systems are discussed.
Induction of labor and early-onset Sepsis guidelines: impact on NICU admissions in Erie County, NY
Authors: Dumpa Vikramaditya , Avulakunta Indira , Shelton James , Yu Taechin , Lakshminrusimha Satyan 
Published: December 2019

Abstract
Background
Elective delivery prior to term gestation is associated with adverse neonatal outcomes. The impact of American College of Obstetricians and Gynecologists (ACOG) guidelines recommending against induction of labor (IOL) < 39 weeks’ postmenstrual age (PMA) on the frequency of early-term births and NICU admissions in Erie County, NY was evaluated in this study.

Methods
This is a population-based retrospective comparison of all live births and NICU admissions in Erie County, NY between pre-and post-ACOG IOL guideline epochs (2005–2008 vs. 2011–2014). Information on early-term, full/late/post-term births and NICU admissions was obtained. A detailed chart analysis of indications for admission to the Regional Perinatal Center was performed.

Results
During the 2005–2008 epoch, early-term births constituted 27% (11,968/44,617) of live births. The NICU admission rate was higher for early-term births (1134/11968 = 9.5%) compared to full/late/post-term (1493/27541 = 5.4%).
In the 2011–2014 epoch, early-term births decreased to 23% (10,286/44,575) of live births. However, NICU admissions for early-term (1072/10286 = 10.4%) and full/late/post-term births (1892/29508 = 6.4%) did not decrease partly due to asymptomatic infants exposed to maternal chorioamnionitis admitted for empiric antibiotic therapy as per revised early-onset sepsis guidelines.

Conclusions
ACOG recommendations against elective IOL or cesarean delivery < 39 weeks PMA were rapidly translated to clinical practice and decreased early-term births in Erie County, NY. This decrease did not translate to reduced NICU admissions partly due to increased NICU admissions for empiric antibiotic therapy.
Incarcerated sigmoid colon cancer in an inguinal hernia sac associated with an abdominal wall abscess: a case report
Authors: Mizuno Hironori , Nagai Hidemasa , Maeda Shingo , Miyake Hideo , Yoshioka Yuichiro , Yuasa Norihiro 
Published: December 2019

Abstract
Background
An inguinal hernia is a common disease; however, a malignant tumor within the inguinal hernia sac is rare, and perforated colon cancer in the hernia sac is extremely rare.

Case presentation
A 73-year-old man presented to our hospital with high fever and painful bulging of the lower abdomen. Computed tomography showed air-containing fluid in the abdominal wall, as well as localized wall thickness of the sigmoid colon in the left groin. An emergency operation revealed a huge subcutaneous abscess and a hard mass of the sigmoid colon within an indirect inguinal hernia sac. Sigmoidectomy and hernia repair using the Marcy method were performed. Lymph node dissection was performed through a transrectal abdominal incision. Histopathological examination of the resected specimen revealed moderately differentiated adenocarcinoma invading the serosal layer with lymph node metastasis.

Conclusions
Incarcerated inguinal hernia with perforated colon cancer is rare; an emergent operation should accordingly be performed based on infection control, oncological principles, and secure hernia repair.
Enhancing the value of accelerometer-assessed physical activity: meaningful visual comparisons of data-driven translational accelerometer metrics
Authors: Rowlands Alex V. , Dawkins Nathan P. , Maylor Ben , Edwardson Charlotte L. , Fairclough Stuart J. , Davies Melanie J. , Harrington Deirdre M. , Khunti Kamlesh , Yates Tom 
Published: December 2019

AbstractThe lack of consensus on meaningful and interpretable physical activity outcomes from accelerometer data hampers comparison across studies. Cut-point analyses are simple to apply and easy to interpret but can lead to results that are not comparable. We propose that the optimal accelerometer metrics for data analysis are not the same as the optimal metrics for translation. Ideally, analytical metrics are precise continuous variables that cover the intensity spectrum, while translational metrics facilitate meaningful, public-health messages and can be described in terms of activities (e.g. brisk walking) or intensity (e.g. moderate-to-vigorous physical activity). Two analytical metrics that capture the volume and intensity of the 24-h activity profile are average acceleration (volume) and intensity gradient (intensity distribution). These allow investigation of independent, additive and interactive associations of volume and intensity of activity with health; however, they are not immediately interpretable. The MX metrics, the acceleration above which the most active X minutes are accumulated, are translational metrics that can be interpreted in terms of indicative activities. Using a range of MX metrics illustrates the intensity gradient and average acceleration (i.e. 24-h activity profile). The M120, M60, M30, M15 and M5 illustrate the most active accumulated minutes of the day, the M1/3DAY the most active accumulated 8 h of the day. We demonstrate how radar plots of MX metrics can be used to interpret and translate results from between- and within-group comparisons, provide information on meeting guidelines, assess individual activity profiles relative to percentiles and compare activity profiles between domains and/or time periods.
Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering
Authors: Chen Cen , Bai Xue , Ding Yahui , Lee In-Seop 
Published: December 2019

Abstract
Recently, electrical stimulation as a physical stimulus draws lots of attention. It shows great potential in disease treatment, wound healing, and mechanism study because of significant experimental performance. Electrical stimulation can activate many intracellular signaling pathways, and influence intracellular microenvironment, as a result, affect cell migration, cell proliferation, and cell differentiation. Electrical stimulation is using in tissue engineering as a novel type of tool in regeneration medicine. Besides, with the advantages of biocompatible conductive materials coming into view, the combination of electrical stimulation with suitable tissue engineered scaffolds can well combine the benefits of both and is ideal for the field of regenerative medicine. In this review, we summarize the various materials and latest technologies to deliver electrical stimulation. The influences of electrical stimulation on cell alignment, migration and its underlying mechanisms are discussed. Then the effect of electrical stimulation on cell proliferation and differentiation are also discussed.
Impact of risk management strategies on the credit risk faced by commercial banks of Balochistan
Authors: Rehman Zia Ur , Muhammad Noor , Sarwar Bilal , Raz Muhammad Asif 
Published: December 2019

AbstractThis study aims to identify risk management strategies undertaken by the commercial banks of Balochistan, Pakistan, to mitigate or eliminate credit risk. The findings of the study are significant as commercial banks will understand the effectiveness of various risk management strategies and may apply them for minimizing credit risk. This explanatory study analyses the opinions of the employees of selected commercial banks about which strategies are useful for mitigating credit risk. Quantitative data was collected from 250 employees of commercial banks to perform multiple regression analyses, which were used for the analysis. The results identified four areas of impact on credit risk management (CRM): corporate governance exerts the greatest impact, followed by diversification, which plays a significant role, hedging and, finally, the bank’s Capital Adequacy Ratio. This study highlights these four risk management strategies, which are critical for commercial banks to resolve their credit risk.
Genomic and human papillomavirus profiling of an oral cancer cohort identifies TP53 as a predictor of overall survival
Authors: Mundi Neil , Prokopec Stephenie D. , Ghasemi Farhad , Warner Andrew , Patel Krupal , MacNeil Danielle , Howlett Christopher , Stecho William , Plantinga Paul , Pinto Nicole , Ruicci Kara M. , Khan Mohammed Imran , Han Myung Woul , Yoo John , Fung Kevin , Sahovaler Axel , Palma David A. , Winquist Eric , Mymryk Joe S. , Barrett John W. , Boutros Paul C. , Nichols Anthony C. 
Published: December 2019

Abtract
Background
The genomic landscape of head and neck cancer has been reported through The Cancer Genome Atlas project. We attempt to determine if high-risk human papillomavirus (HPV) or frequently mutated genes are correlated with survival in an oral cancer cohort.

Methods
Patient demographic data along with data from final pathology was collected. Tumor DNA was analyzed using a custom Illumina targeted sequencing panel. Five high-risk HPV types were tested by qPCR. Statistical analyses were used to identify associations between patient outcome and mutational status.

Results
High-risk HPV types were identified in 7% of cases; HPV status was not associated with survival. Mutations were identified in TP53, TERT promoter, & PIK3CA. Mutations in TP53 were significantly associated with poorer overall survival on multi-variate analysis (p = 0.03).

Conclusions
Mutations in TP53 were associated with poor patient survival. Expanding our sample size may identify further predictors of outcome to direct customized cancer care.
DNA barcoding of different Triticum species
Authors: Osman Samira A. , Ramadan Walaa A. 
Published: December 2019

AbstractBackgroundThe genusTriticumL. includes diploid, tetraploid, and hexaploid species. DNA barcoding is a new method to identify plant taxa by using short sequences of DNA and within a short time. In this investigation, we determined a phylogenetic analysis of 20 differentTriticumspecies by partial chloroplast Maturase encoding gene (matK).Materials and methodsTwenty accessions of differentTriticumspecies diploid, tetraploid, and hexaploid were obtained from different countries. Genomic DNA was isolated from young leaves of studied samples and then used as a template for PCR reaction. PCR products were checked by electrophoresis, purified, sequenced, and submitted in the GenBank nucleotide sequence database, the nucleotide sequence was translated into an amino acid sequence. The nucleotide and amino acid sequences were aligned with Clustal W multiple sequence alignment programs to obtain the phylogenetic tree depending on two statistical data analysis such as bootstrapping and pairwise distance from both nucleotide and amino acid sequences.ResultsThe phylogenetic tree obtained from both nucleotide and amino acid sequences divided the 20Triticumspecies into two groups, A and B.Group Arepresented the diploidTriticumspecies. Group B was divided into two subgroup, I and II. Subgroup I represented the hexaploidTriticumspecies and subgroup II represented the tetraploid species.ConclusionThematKgene sequence has a critical role in discriminating the closely relatedTriticumspecies. So these sequences could be used as a DNA barcode for detecting the evolutionary history ofTriticumspecies.