bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ta’līm Mahārah al-Istima’ li Thullāb Ghair an-Nāthiqīn bil-‘Arabiyyah fi al-Madrasah ats-Tsānawiyyah
Authors: Jubaidah Siti 
Published: December 2020

This study aims to determine how the implementation of listening learning for students who are non native speakers at the Madrasah Aliyah, and whether the factors that influence the differences in the implementation of listening learning for non-native students at the Madrasah Aliyah. This research is a qualitative descriptive study by describing the implementation of listening learning for non-native students at Madrasah Aliyah. The subjects of the study were Arabic Madrasah Aliyah teachers and students in Malang, East Java Regency. Data collection techniques in this study were interviews and observations. From this research, it is known that the implementation of listening learning for non-native speakers at Madrasah Aliyah level is divided into 3 categories, which are always applied, often applied, and sometimes applied. Each of these categories includes learning objective, material, method, media, and evaluation. Factors that influence the differences in the implementation of learning are differences in teacher creativity, material; media, evaluation; and limited facilities.
Keywords: Listening Learning; non-native students; Madrasah Aliyah
DETERMINAN EFISIENSI PERBANKAN DI INDONESIA (STUDI EMPIRIS PADA BANK UMUM SYARIAH DI INDONESIA PERIODE 2012-2018)
Authors: Wulandari Sri Farhatin , Ryandono Muh. Nafik Hadi 
Published: December 2020

ABSTRAKEfisiensi merupakan salah satu indikator penting dalam mengukur kinerja keseluruhan dari aktivitas perbankan. Penelitian ini bertujuan untuk mengetahui pengaruh variabel Capital Adequacy Ratio (CAR), Financing to Deposito Ratio (FDR), Net Interest Margin (NIM), dan Bank Size terhadap Efisiensi Bank Umum Syariah di Indonesia periode 2012-2018 yang diproksikan melalui Beban Operasional Pendapatan Operasional (BOPO). Metode yang digunakan adalah metode kuantitatif dengan teknik analisis regresi data panel menggunakan alat statistik Eviews 9.0. Data yang digunakan adalah data sekunder dengan teknik pengambilan sampel purposive sampling sehingga menghasilkan sampel sebanyak 11 Bank Umum Syariah di Indonesia. Hasil penelitian ini menunjukkan bahwa secara simultan variabel Capital Adequacy Ratio (CAR), Financing to Deposito Ratio (FDR), Net Interest Margin (NIM), dan Bank Size berpengaruh signifikan terhadap Efisiensi Bank Umum Syariah di Indonesia periode 2012-2018. Selanjutnya, secara parsial Capital Adequacy Ratio (CAR), berpengaruh negative dan signifikan, Financing to Deposito Ratio (FDR) berpengaruh positif dan signifikan, Net Interest Margin (NIM) berpengaruh positif dan tidak signifikan, dan Bank Size berpengaruh negatif dan signifikan terhadap efisiensi perbankan syariah.Kata Kunci: Efisiensi, CAR, FDR, NIM, Bank Size, Bank Syariah. ABSTRACTEfficiency is an important indicator in measuring the overall performance of banking activities. This study aimed to determine the effect of the variable Capital Adequacy Ratio (CAR), Financing to Deposit Ratio (FDR), Net Interest Margin (NIM), and Bank Size on the Efficiency of Sharia Commercial Banks in Indonesia for the period 2012-2018, proxied through Operational Income Operational Expenses (BOPO). The method used was a quantitative method with panel data regression analysis techniques using statistical tools Eviews 9.0. The data were secondary data with purposive sampling technique to produce a sample of 11 Sharia Commercial Banks in Indonesia. The results of this study showed that simultaneously the variables of Capital Adequacy Ratio (CAR), Financing to Deposit Ratio (FDR), Net Interest Margin (NIM), and Bank Size had a significant effect on the Efficiency of Islamic Commercial Banks in Indonesia for the period 2012-2018. Furthermore, partially Capital Adequacy Ratio (CAR) had a negative and significant effect, Financing to Deposit Ratio (FDR) had a positive and significant effect, Net Interest Margin (NIM) had a positive and insignificant effect, and Bank Size had a negative and significant effect on Sharia banking efficiency.Keywords: Efficiency, CAR, FDR, NIM, Bank Size, Sharia Bank.
Dampak Contract Farming terhadap Kinerja Usahatani Kopi di Lampung
Authors: Rosanti Novi , Sinaga Bonar M , Daryanto Arief , Kariyasa Ketut 
Published: December 2020

Penelitian ini bertujuan untuk menganalisis dampak contract farming terhadap kinerja usahatani kopi di Lampung. Penelitian dilakukan di Kabupaten Lampung Barat dan Tanggamus yang merupakan sentra produksi kopi di Lampung. Survei rumahtangga petani dilakukan pada bulan Mei sampai Juni 2018. Sampel pada penelitian ini berjumlah 170 responden yang terdiri dari 98 petani kontrakdan72 petani non kontrak. Penelitian ini mengestimasi dampak contract farming menggunakan teknik Propensity Score Matching (PSM). Hasil penelitian menunjukkan bahwa contract farming berdampak positif terhadap produktivitas, harga, dan pendapatan usahatani kopi. Mempromosikan dan mendorong penyebaran contract farming secara lebih luas dapat menjadi salah satu cara untuk meningkatkan produktivitas kopi nasional, daya saing dan kesejahteraan petani.
Common social determinants for overweight and obesity, and dental caries among adolescents in Northern Norway: a cross-sectional study from the Tromsø Study Fit Futures cohort.
Authors: Stangvaltaite-Mouhat Lina , Furberg Anne-Sofie , Drachev Sergei N. , Trovik Tordis A. 
Published: December 2020

Abstract
Background. Non-communicable general and oral health conditions share common risk factors. Studies investigating common social determinants as risk factors for overweight/obesity and dental caries among the same adolescents are scarce and inconclusive. Methods. This cross-sectional study included data from 464 girls and 494 boys from the population-based Tromsø study Fit Futures, which included first-year students attending upper secondary school in 2010-2011 from two municipalities in Northern Norway (1038 participants in total, 93% participation rate). Multivariable binary logistic regression analyses stratified by sex were used to investigate the association between socioeconomic position indicators (adolescent’s own study program, parents’ education and employment status) and overweight/obesity indicated by body weight and waist circumference, untreated dental caries in dentine, and when these conditions were considered simultaneously.Results. Boys enrolled in the general studies and sports programs (versus vocational) had lower odds of being overweight/obese (POR 0.42, 95% CI 0.20-0.86 and POR 0.24, 95% CI 0.08-0.73, respectively), of having high waist circumference (POR 0.39, 95% CI 0.21-0.75 and POR 0.25, 95% CI 0.10-0.64, respectively), dental caries (POR 0.57, 95% CI 0.32-0.99 and POR 0.47, 95% CI 0.22-0.98, respectively), and being simultaneously overweight/obese, having high waist circumference and dental caries (POR 0.24, 95% CI 0.07-0.81 and POR 0.11, 95% CI 0.01-0.98, respectively). Girls enrolled in the general studies program (versus vocational) had lower odds of having dental caries (POR 0.50, 95% CI 0.30-0.84). Conclusions. Adolescent’s own study program was identified to be a common social determinant for overweight/obesity and dental caries among boys. These results support the broader concept of social determinants as common risk factors for general and oral health conditions, and call for common health promotion strategies addressing these common social determinants among adolescents. However, there is a need for more studies to investigate and better understand the influence of social determinants on health conditions among adolescents.
Quality of life of university students during the COVID-19 pandemic: Assessing the level of quality of life and the associated factors after the end of movement lockdown
Authors: Abdullah Mohammad Farris Iman Leong Bin , Murad Nor Shuhada , Teoh Soo Huat , Mohamad Mohd Afifuddin 
Published: December 2020

Abstract
Purpose: Despite the significant impact of COVID-19 on mental health among university students, data on the related quality of life (QoL) are lacking in this group of the population. This study aimed to evaluate quality of life (QoL) and determine its association with various factors and social support among university students during the COVID-19 pandemic after the end of movement lockdown. Methods: This was an online, cross-sectional study recruited a total of 316 participants. Participants were administered a self-reported questionnaire to gather data on demographic, personal, clinical and psychological characteristics; the 21-item depression, anxiety and stress scale (DASS-21) to assess the severity of their depressive, anxiety and stress symptoms; the multidimensional scale of perceived social support (MSPSS) to assess the degree of social support; and the World Health Organization quality of life-BREF (WHOQoL-BREF) to assess QoL. Results: The psychological and social QoL scores were lower than the non-pandemic norms of the general population, while the physical health and environmental QoL scores were comparable. After adjusting for relevant demographic, personal, and clinical variables, religious coping; greater number of hours of online classes attended; and greater social support from family, friends and significant others were found to be significantly associated with higher QoL among the participants. Frustration because of study disruption, living in areas with a high prevalence of COVID-19 cases, and a higher severity of depressive and stress symptoms were significantly associated with lower QoL. Conclusion: COVID-19 impaired the QoL of university students even after the movement lockdown was lifted.
Genetic Analysis of Sinonasal Undifferentiated Carcinoma Discovers Recurrent SWI/SNF Alterations and a novel PGAP3-SRPK1 Fusion Gene
Authors: Neal Molly Heft , Birkeland Andrew , Bhangale Apurva , Zhai Jingyi , Kulkarni Aditi , Foltin Susan , Jewell Brittany , Ludwig Megan , Pinatti Lisa , Jiang Hui , McHugh Jonathan , Marentette Lawence , McKean Erin , Brenner J 
Published: December 2020

Abstract
Background: Sinonasal Undifferentiated Carcinoma (SNUC) is a rare and aggressive skull base tumor with poor survival and limited treatment options. To date, targeted sequencing studies have identified IDH2 and SMARCB1 as potential driver alterations, but the molecular alterations found in SMARCB1 wild type tumors are unknown.Methods: We evaluate survival outcomes in a cohort of 46 SNUC patients treated at an NCI designated cancer center and identify clinical and disease variables associated with survival on Kaplan-Meier and Cox multivariate survival analysis. We perform exome sequencing to characterize a series of SMARCB1 wild type tumors and cell line including identification of high confidence mutations, copy number alterations, microsatellite instability, and fusions. Knockdown studies using siRNA was utilized for validation of a novel PGAP3-SRPK1 gene fusion. Results: We discover recurrent aberrations to the SWI/SNF and FAT gene families. We also validate a novel PGAP3-SRPK1 gene fusion in the SNUC cell line, and show that knockdown of the fusion is negatively associated with EGFR, E2F and MYC signaling. Conclusion: Collectively, these data demonstrate recurrent alterations in the SWI/SNF and FAT gene families and discover a novel fusion gene (PGAP3-SRPK1). These data aim to improve understanding of possible driver mutations and guide future therapeutic strategies for this disease.
Insight of characteristic of mutation sequences in human cancers via an unsupervised neural network approach.
Authors: Hongchen Ji , Junjie Li , Qiong Zhang , Jingyue Yang , Fei Tian , Xiaowen Wang , Pan W. , Wang X. X. , Hongmei Zhang 
Published: December 2020

Abstract
Background: Mutation processes leave different signatures in genes. Previous studies have suggested that both the mutated and flanking bases influence somatic mutation characteristics. However, the understanding of how flanking sequences influence somatic mutation characteristics is limited.Materials and methods: We constructed a long short-term memory – self organizing map (LSTM-SOM) unsupervised neural network. By extracting mutated sequence features via LSTM and clustering similar features with SOM, somatic mutations in The Cancer Genome Atlas database were clustered according to their mutation type and flanking sequences. The relationship between MB and cancer characteristics was then analyzed. At last, we clustered the patients into different classes according to the composition of MB by K-means method, and then studied the differences in clinical features and survival between classes.Results: Ten classes of mutant sequences (named mutation blots, MBs) were obtained from 2,141,527 somatic mutations. Different features in mutation bases and flanking sequences were revealed among MBs. MB reflect both the site and pathological features of cancers. MBs were related to clinical features, including age, sex, and cancer stage. Class of MB in a given gene is associated with survival. Finally, patients were clustered into 7 classes according to MB composition. Significant differences in survival and clinical features were observed among different patient classes.Conclusions: Our study provides a novel method for analyzing the information of mutant sequences and reveals the extensive relationships among mutant sequences, clinical features, and cancer patient survival.
General synthesis of high-entropy alloy and ceramic nanoparticles in nanoseconds
Authors: Zou Zhigang , Wang Bing , Wang Cheng , Yu Xiwen , Cao Yuan , Gao Linfeng , Luo Wenjun , Wu Congping , Yao Yingfang , Lin Zhiqun 
Published: December 2020

Abstract
High-entropy materials (HEMs) including high-entropy alloys (HEAs) and high-entropy ceramics (HECs) at nanoscale have promising prospects in many fields, yet a robust synthesis strategy is lacking. Herein, we present a simple and general approach, laser scanning ablation (LSA), to synthesize a vast library of HEA and HEC nanoparticles (NPs) including alloys, sulfides, oxides, borides, nitrides, phosphides. The LSA method takes only 5 nanoseconds per pulse to ablate the corresponding NPs precursors at atmospheric temperature and pressure in alkanes. The ultra-rapid process ensures up to 9 dissimilar metallic elements combined uniformly regardless of their thermodynamic solubility. As laser pulse precisely confines energy to desired microregions, the LSA method enables HEM NPs loading on various substrates, even thermally-sensitive ones such as metals and glass. Applied as electrocatalysts for overall water splitting, HEM NPs achieved an overpotential of 185 mV @ 10mA cm-2, which was among the best activities. The LSA technique discloses a large collection of new nanostructured HEMs with unique properties and attractive functions. We believe this general strategy will provide a versatile and flexible material platform for a wild range of fields such as biology, catalysis, electronics and magnetics.
Equivalent Hazard Magnitude Scale
Authors: Wang Yi , Sebastian Antonia 
Published: December 2020

Abstract
Effective management of natural hazards requires the capability of cross-hazard evaluations. However, existing hazard magnitude scales cannot be easily adapted to evaluate sizes of events across different hazard types. Here, we propose a regression-based methodology with historical data on hazard impacts and magnitude indicators worldwide from 1900 to 2020 to derive an equivalent magnitude scale, called the Gardoni Scale after Professor Paolo Gardoni, to effectively quantify and compare sizes of events across twelve natural hazard types. Our results suggest that when compared on the Gardoni Scale, tsunami and drought disasters tend to have large magnitudes, while tornadoes are relatively small in size. We further propose hazard equivalency as a new area of research for cross-hazard evaluations of sizes and intensities of natural hazard events. Continuing efforts in this new area will strengthen guidance for resource allocation for hazard management, facilitate disaster communication, and enhance risk analysis within a multi-hazard context.
Development of an Emergency Nursing Care Competency Scale for School Nurses
Authors: Yoon Jaehee 
Published: December 2020

Abstract
Background The school nurse is a vital component of the school emergency services. Assessing School nurses’ emergency nursing care competency is essential to be sure safety and quality of care. The purpose of the study was to develop a scale for measuring school nurses’ competency.Methods This was an instrument development and validation study. The study was conducted according to the revised DeVellis scale development process coupled with the application of the International Council of Nurses’ Nursing Care Continuum Competencies Framework. Eight experts who specialize in school health and emergency care evaluated the validity of the content, while 386 school nurses evaluated the scale. The validity evaluation comprised factor analysis, analysis of control group validity according to school nurse experience differences, and analysis of criterion validity. Scale reliability was analyzed using Cronbach’s α value.Results The final scale comprises a self-reported 5-point Likert scale with 30 items, based on three factors and three sub-factors. The convergent validity of the items by factor and control group validity were both confirmed. The criterion validity was also found to be positively correlated with the Triage Competency Scale.Conclusion The scale may be used to identify factors influencing school nurses’ competency in emergency nursing care and contribute to research in competency-based education programs.
Aortic valve function post-replacement of severe aortic stenosis by transcatheter procedure versus surgery: A systematic review and metanalysis
Authors: Khalil Charbel Abi , Ignatiuk Barbara , Erdem Guliz , Chemaitelly Hiam , Barilli Fabio , El-Shazly Mohamed , Suwaidi Jassim Al , Aboulsoud Samar , Kofler Markus , Stastny Lukas , Jneid Hani , Bonaros Nikolaos 
Published: December 2020

Abstract
Transcatheter aortic valve implantation (TAVI) has shown to reduce mortality compared to surgical aortic valve replacement (sAVR). However, it is known which procedure is associated with better post-procedural valvular function. We conducted a meta-analysis of randomized clinical trials that compared TAVI to sAVR for at least 2 years. The primary outcome was post-procedural patient-prosthesis-mismatch (PPM). Secondary outcomes were post-procedural and 2-year: effective orifice area (EOA), paravalvular gradient (PVG) and moderate/severe paravalvular leak (PVL). We identified 6 trials with a total of 7022 participants with severe aortic stenosis. TAVI was associated with 37% (95% CI [0.51-0.78) mean RR reduction of post-procedural PPM, a decrease that was not affected by the surgical risk at inclusion, neither by the transcatheter heart valve system. Postprocedural changes in gradient and EOA were also in favor of TAVI as there was a pooled mean difference decrease of 0.56 (95% CI [0.73-0.38]) in gradient and an increase of 0.47 (95% CI [0.38-0.56]) in EOA. Additionally, self-expandable valves were associated with a higher decrease in gradient than balloon ones (beta= 0.38; 95% CI [0.12-0.64]). However, TAVI was associated with a higher risk of moderate/severe PVL (pooled RR: 9.54, 95% CI [5.53-16.46]). All results were sustainable at 2 years.
Real-world Comparison of StreamLightTM&nbsp;trans-PRK and Conventional PRK&nbsp;With Regard to Refractive Outcome, Wound Healing, Pain Intensity and Visual Recovery Time
Authors: Gaeckle Harald 
Published: December 2020

Abstract
PurposeTo compare clinical outcomes of single-step transepithelial photorefractive keratectomy (tPRK) and conventional photorefractive keratectomy (PRK) regarding refractive outcome, visual acuity, wound healing, pain intensity and visual recovery time.MethodsIn this prospective clinical observational study 200 eyes of 100 consecutive patients with mild to moderate myopia with or without mild astigmatism were included. One hundred eyes each were treated with StreamLightTM tPRK or conventional PRK with the WaveLight® EX500 excimer laser. Visual acuity (Decimal) was assessed preoperatively and at day 4, 7 and 6 weeks postoperatively. Wound healing (hours between surgery and complete epithelial closure) was monitored at the slit lamp. Subjective pain intensity level was evaluated by a numeric pain rating scale (0 – 15) at day 4.ResultsVisual recovery was significantly faster in the tPRK group. At days 4 and 7, the mean monocular UCDVA was significantly better in the tPRK group than in the PRK group (p < 0.001). Four days after surgery 72% of eyes in the tPRK group but no eye in the PRK had an UCDVA of 0.7 or better. At six weeks postoperatively, UCDVA of 1.0 or better was achieved in both groups. Complete epithelial wound closure was achieved significantly faster in the tPRK group (p < 0.0001) and maximum pain level within the first 4 days after surgery was significantly lower in the tPRK group (p < 0.0001). No patient had lost a line of BCDVA and no complications or adverse effects were observed.ConclusionBoth treatments offer a safe and effective correction of low to moderate myopia with and without astigmatism. However, StreamLightTM tPRK offers faster visual recovery and epithelial healing and is associated with less pain as compared to conventional PRK. It can therefore be considered a good treatment option for patients who refuse or are not eligible for Femto-LASIK, but at the same time demand a faster and more comfortable recovery time than conventional PRK can offer.
An Integrated Stress Response Pathway activates Perivascular Cancer-Associated Fibroblasts to Drive Angiogenesis and Tumor Progression
Authors: Verginadis Ioannis , Avgousti Harris , Monslow James , Skoufos Giorgos , Chinga Frank , Leli Nektaria Maria , Karagounis Ilias , Bell Brett , Salinas Carlo Salas , Li Yang , Ye Jiangbin , Scott David , Osterman Andrei , Sengupta Arjun , Weljie Aalim , Radaelli Enrico , Tobias John , Rambow Florian , Karras Panagiotis , Marine Jean-Christophe , Xu Xiaowei , Hatzigeorgiou Artemis , Ryeom Sandra , Diehl J Alan , Fuchs Serge , Pure' Ellen , Koumenis Constantinos 
Published: December 2020

Abstract
ATF4 is a major effector of the Integrated Stress Response (ISR), a homeostatic mechanism coupling cell growth and survival to bioenergetic demands. Although the pro-tumorigenic role of the ISR in a tumor cell-intrinsic manner has been established, its role in cell-extrinsic processes remains unexplored. Using novel conditional knockout ATF4 mouse models, we show that global, or fibroblast (FB)-specific loss of host ATF4 results in abnormal tumor vascularization and a pronounced tumor growth delay in syngeneic melanoma and pancreatic tumor models, a phenotype which is largely reversed by co-injection of ATF4wt/wt FBs. Single-cell tumor transcriptomics uncovered a reduction of markers associated with FB activation in a cluster of perivascular cancer-associated fibroblasts (CAF) in ATF4Δ/Δ mice. ATF4Δ/Δ FBs displayed significant defects in collagen biosynthesis and deposition and reduced ability to support angiogenesis in vitro. Mechanistically, ATF4 directly regulates the expression of the Col1a1 gene as well as the biosynthesis of glycine and proline, the major amino acids comprising collagen fibers. Analysis of human tumor samples revealed a strong correlation between ATF4 and collagen levels and between an ATF4 FB signature and expression of collagen genes. Our findings uncover a novel role of stromal ATF4 in shaping CAF functionality, a key driver of disease progression and therapy resistance.