bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal blood metal concentrations and whole blood DNA methylation during pregnancy in the Early Autism Risk Longitudinal Investigation (EARLI)
Authors: Aung Max T. , Bakulski Kelly M. , Feinberg Jason I. , Dou John F. , Meeker John D. , Mukherjee Bhramar , Loch-Caruso Rita , Ladd-Acosta Christine , Volk Heather E. , Croen Lisa A. , Hertz-Picciotto Irva , Newschaffer Craig J. , Fallin M. Daniele 
Published: May 2020

AbstractBackgroundMetals exposures have important health effects in pregnancy. The maternal epigenome may be responsive to these exposures. We tested whether metals are associated with concurrent differential maternal whole blood DNA methylation.MethodsIn the Early Autism Risk Longitudinal Investigation (EARLI) cohort, we measured first or second trimester maternal blood metals concentrations (cadmium, lead, mercury, manganese, and selenium) in 215 participants using inductively coupled plasma mass spectrometry. DNA methylation in maternal whole blood was measured in the same specimens on the Illumina 450K array (201 participants). A subset sample of 97 women had both measures available for analysis, all of whom did not report smoking during pregnancy. Linear regression was used to test for site-specific associations between individual metals and DNA methylation, adjusting for cell type composition and confounding variables. Discovery gene ontology analysis was conducted on the top 1,000 sites associated with each metal to elucidate downstream pathways.ResultsIn multiple linear regression, we observed hypermethylation at 11 DNA methylation sites associated with lead (FDR q-value <0.1), near the genes CYP24A1, ASCL2, FAT1, SNX31, NKX6-2, LRC4C, BMP7, HOXC11, PCDH7, ZSCAN18, and VIPR2. Lead associated sites were enriched (FDR q-value <0.1) for the pathways cell adhesion, nervous system development, and calcium ion binding. Manganese was associated with hypermethylation at four DNA methylation sites (FDR q-value <0.1), one of which was near the gene ARID2. Manganese associated sites were enriched for cellular metabolism pathways (FDR q-value<0.1). Effect estimates for DNA methylation sites associated (p<0.05) with cadmium, lead, and manganese were highly correlated (Pearson ρ >0.86).DiscussionSingle DNA methylation sites associated with lead and manganese may be potential biomarkers of exposure or implicate downstream gene pathways. Future studies should replicate our findings to characterize potential toxicological mechanisms of trace metals through the maternal epigenome.
Non-pharmaceutical behavioural measures for droplet-borne biological hazards prevention: Health-EDRM for COVID-19 (SARS-CoV-2) Pandemic
Authors: Chan Emily Ying Yang , Shahzada Tayyab Salim , Sham Tiffany Sze Tung , Dubois Caroline , Huang Zhe , Liu Sida , Ying-en Ho Janice , KC Hung Kevin , On Kwok Kin , Kayano Ryoma , Shaw Rajib 
Published: May 2020

AbstractIntroductionNon-pharmaceutical interventions to facilitate response to the COVID-19 pandemic, a disease caused by novel coronavirus SARS-CoV-2, are urgently needed. Using the WHO health emergency and disaster risk management (health-EDRM) framework, behavioural measures for droplet-borne communicable disease, with their enabling and limiting factors at various implementation levels were evaluated.Sources of dataKeyword search was conducted in PubMed, Google Scholar, Embase, Medline, Science Direct, WHO and CDC online publication database. Using OCEBM as review criteria, 105 English-language articles, with ten bottom-up, non-pharmaceutical prevention measures, published between January 2000 and May 2020 were identified and examined.Areas of AgreementEvidence-guided behavioural measures against COVID-19 transmission for global at-risk communities are identified.Area of ConcernStrong evidence-based systematic behavioural studies for COVID-19 prevention are lacking.Growing pointsVery limited research publications are available for non-pharmaceutical interventions to facilitate pandemic response.Areas timely for researchResearch with strong implementation feasibility that targets resource-poor settings with low baseline Health-EDRM capacity is urgently need.
COVID 19: An SEIR model predicting disease progression and healthcare outcomes for Pakistan
Authors: Ahmad Khan Ejaz , Umar Maida , Khalid Maryam 
Published: May 2020

AbstractBackgroundRecent pandemic of the Noval Coronal Virus (COVID 19) has claimed more than 200,000 lives and about 3.8 million infected worldwide. Countries are being gradually exposed to its devastating threat without being properly prepared and with inadequate response. COVID 19’s first two cases were reported in Pakistan on February 26, 2020. We present a model depicting progression of epidemiology curve for Pakistan with and without interventions in view of its health system’ response capacity in near future.MethodologyWe used a modified compartmental epidemiological SEIR model to describe the outbreak of COVID-19 in Pakistan including the possibility of asymptomatic infection and presymptomatic transmission. The behavior of the dynamic model is determined by a set of clinical parameters and transmission rate.ResultsWe estimated that in the absence of a set of proven interventions, the total susceptible population would be 43.24 million, exposed individuals would be almost 32 million, asymptomatic cases would be 13.13 million, mildly infected 30.64 million, severely infected slightly more than 6 million and critical cases would be around 967,000 in number. By that time, almost 760,000 fatalities of infected critical would have taken place. Comparing with the healthcare capacity of Pakistan, if we could “flatten the curve” to a level below the dashed grey line, the healthcare system will be capable of managing the cases with ideal healthcare facilities, where the grey line representing the healthcare capacity of Pakistan. With the intervention in place, the number of symptomatic infected individuals is expected to be almost 20 million.ConclusionWe consider the impact of intervention and control measures on the spread of COVID-19 with 30% reduction in transmission from mild cases in case a set of interventions are judiciously in place to mitigate its impact.
Uncoupling of DNA replication and centrosome duplication cycles is a primary cause of haploid instability in mammalian somatic cells
Authors: Yoshizawa Koya , Yaguchi Kan , Uehara Ryota 
Published: May 2020

AbstractMammalian haploid somatic cells are unstable and prone to diploidize, but the cause of haploid instability remains largely unknown. Previously, we found that mammalian haploid somatic cells suffer chronic centrosome loss stemming from the uncoupling of DNA replication and centrosome duplication cycles. However, the lack of methodology to restore the coupling between DNA replication and centrosome duplication has precluded us from investigating the potential contribution of the haploidy-linked centrosome loss to haploid instability. In this study, we developed an experimental method that allows the re-coupling of DNA and centrosome cycles through the chronic extension of the G1/S phase without compromising cell proliferation using thymidine treatment/release cycles. Chronic extension of G1/S restored normal mitotic centrosome number and mitotic control, substantially improving the stability of the haploid state in HAP1 cells. Stabilization of the haploid state was compromised when cdk2 was inhibited during the extended G1/S, or when early G1 was chronically extended instead of G1/S, showing that the coupling of DNA and centrosome cycles rather than a general extension of the cell cycle is required for haploid stability. Our data indicate the chronic centriole loss arising from the uncoupling of centrosome and DNA cycles as a direct cause of genome instability in haploid somatic cells, and also demonstrate the feasibility of modulation of haploid stability through artificial coordination between DNA and centrosome cycles in mammalian somatic cells.
Genome-Wide Characterization of DNase I-Hypersensitive Sites and Cold Response Regulatory Landscapes in Grasses
Authors: Han Jinlei , Wang Pengxi , Wang Qiongli , Lin Qingfang , Chen Zhiyong , Yu Guangrun , Miao Chenyong , Dao Yihang , Wu Ruoxi , Schnable James C. , Tang Haibao , Wang Kai 
Published: May 2020

Abstract
Deep sequencing of DNase-I treated chromatin (DNase-seq) can be used to identify DNase I-hypersensitive sites (DHSs) and facilitates genome-scale mining of de novo cis-regulatory DNA elements. Here, we adapted DNase-seq to generate genome-wide maps of DHSs using control and cold-treated leaf, stem, and root tissues of three widely studied grass species: Brachypodium distachyon, foxtail millet (Setaria italica), and sorghum (Sorghum bicolor). Functional validation demonstrated that 12 of 15 DHSs drove reporter gene expression in transiently transgenic B. distachyon protoplasts. DHSs under both normal and cold treatment substantially differed among tissues and species. Intriguingly, the putative DHS-derived transcription factors (TFs) are largely colocated among tissues and species and include 17 ubiquitous motifs covering all grass taxa and all tissues examined in this study. This feature allowed us to reconstruct a regulatory network that responds to cold stress. Ethylene-responsive TFs SHINE3, ERF2, and ERF9 occurred frequently in cold feedback loops in the tissues examined, pointing to their possible roles in the regulatory network. Overall, we provide experimental annotation of 322,713 DHSs and 93 derived cold-response TF binding motifs in multiple grasses, which could serve as a valuable resource for elucidating the transcriptional networks that function in the cold-stress response and other physiological processes.
Moderation effect of competence of knowledge and innovation: case of Bali
Authors: Usman Irwan , Maupa Haris , Idrus Muhammad , Haerani Siti , Nurjanna Nurjanna 
Published: May 2020

PurposeThis paper examines how market orientation and competence of knowledge reinforce the innovation and in turn improve the business performance.Design/methodology/approachThis research applied research design with quantitative approach based on positivism philosophy, that is, research aimed to test the theory and data which is general to produce findings that are special through hypothesis test. This study was supplemented by field studies as a necessary source of data in the form of trends, attitudes, opinions, perceptions of owners, managers or senior employees of SMEs in the textile industry in Bali, related to the variables used in this study.Findings(1) Market orientation influences business performance, (2) competence of knowledge moderates the influence of market orientation on business performance, (3) innovation moderates the influence of market orientation on business performance.Originality/value(1) Novelty of this research is developing the concept of competence of knowledge associated with business performance in which this relationship has not yet been expressed. (2) Building the concept of innovation development of small-scale industry based on the market orientation. (3) Developing the concept of innovative development of small and medium enterprises of textile industry based on competence of knowledge. (4) Investigating the concept of market orientation and competence of knowledge in an integrated and holistic way to strengthen the innovation and business performance of SMEs of the textile industry in Bali.
Change-efficacy: the glue that connects organizational change with employees’ actions
Authors: Budhiraja Sunil 
Published: May 2020

Purpose
The article presents and discusses the concept of employee change-efficacy as an outcome of a series of interactions between employees and their respective line managers.

Design/methodology/approach
The article draws from the extant literature on change-efficacy and builds a procedural framework for achieving change-efficacy based upon the author’s independent viewpoint.

Findings
Most organizations are struggling with change resistance and they are investing in employee readiness to change without following a practical topology. The article prescribes a sequence of steps and a practical guide which integrates the efforts of line managers with employees to strengthen employees’ change-efficacy.

Research implications
The article contributes to the scarce literature on change-efficacy and indicates a framework which can be tested empirically by researchers.

Originality/value
The author introduces change-efficacy as the most important investment for employee readiness for change and suggests how organizations should channelize their change management efforts to successfully implement change.
A Chebyshev convex method for mid-frequency analysis of built-up structures with large convex uncertainties
Authors: Qin Wu , Yin Hui , Yu D.J. , Shangguan Wen-Bin 
Published: May 2020

Purpose
This paper aims to develop an efficient numerical method for mid-frequency analysis of built-up structures with large convex uncertainties.

Design/methodology/approach
Based on the Chebyshev polynomial approximation technique, a Chebyshev convex method (CCM) combined with the hybrid finite element/statistical energy analysis (FE-SEA) framework is proposed to fulfil the purpose. In CCM, the Chebyshev polynomials for approximating the response functions of built-up structures are constructed over the uncertain domain by using the marginal intervals of convex parameters; the bounds of the response functions are calculated by applying the convex Monte–Carlo simulation to the approximate functions. A relative improvement method is introduced to evaluate the truncated order of CCM.

Findings
CCM has an advantage in accuracy over CPM when the considered order is the same. Furthermore, it is readily to consider the CCM with the higher order terms of the Chebyshev polynomials for handling the larger convex parametric uncertainty, and the truncated order can be effectively evaluated by the relative improvement method.

Originality/value
The proposed CCM combined with FE-SEA is the first endeavor to efficiently handling large convex uncertainty in mid-frequency vibro-acoustic analysis of built-up structures. It also has the potential to serve as a powerful tool for other kinds of system analysis when large convex uncertainty is involved.
Reimagining proactive strategic planning toward patient-centered care: processes and outcomes in a medical school's department of family and community medicine
Authors: Aultman Julie , Kingsbury Diana , Baughman Kristin , Fischbein Rebecca , Boltri John M. 
Published: May 2020

PurposeA detailed strategic planning process is presented that entails several beneficial and effective strategies and goals for interdisciplinary academic, clinical and/or service departments. This strategic planning process emerged due to the need to adapt to organizational and structural changes within an institution of higher medical education.Design/methodology/approachA strategic planning framework was developed, along with an inclusive process that used an appreciative inquiry methodology, to examine past and present strengths and potentials in a diverse, interdisciplinary family and community medicine department.FindingsThe success of this strategic plan and relevant approaches is evidenced by the development of a community medicine course, student-run free clinic to meet the needs of underserved patients, an increase in primary care research and increase in student choice of family medicine as specialty choice.Research limitations/implicationsThe described strategic planning process serves as an illustration of the benefits and limitations of identified approaches and outcomes useful for other departments and organizations undertaking similar efforts.Originality/valueThe integration of multiple goals and a shared vision in a strategic planning process leads to successful program development and meeting the needs of future healthcare professionals and the patients and communities they serve. The authors have provided a model for such success.
Harmonious workplace climate and employee altruistic behavior: from social exchange perspective
Authors: Bui Hong T.M. , Liu Gordon , Ko Wai Wai , Curtis Amy 
Published: May 2020

PurposeDrawing on the social exchange perspective, the authors explore the roles of satisfaction over material rewards, perceived organizational politics and career ambition in the relationship between harmonious workplace climate and employee altruistic behavior in the context of British public sector.Design/methodology/approachThe authors employed SPSS software to estimate ordinary least squares models to test their hypotheses by analyzing data from 161 supervisor–employee dyads from a UK local government.FindingsSatisfaction over material rewards mediates the relationship between harmonious workplace climate and employee altruistic behavior. Both perceived organizational politics and career ambition moderate the mediated effect of harmonious workplace climate on employee altruistic behavior via satisfaction over material rewards.Originality/valueThis study advances the social exchange theory by showing that the norm of reciprocity (e.g. harmonious workplace climate in this study) may not be the only key driver of exchange for altruistic behavior among public sector workers. Still, it can be mediated by satisfaction with pay and promotion opportunities and may be conditional upon individuals' career ambition or their perceptions of organizational politics.
Working women with disabilities: evidence from the Jordanian public sector
Authors: Ababneh Raed Ismail , AlShaik Aseel 
Published: May 2020

Purpose
This study aims to identify the level of human resource management difficulties (job suitability, training and development, motivation and performance appraisal) women employees with disabilities face in the Jordanian public sector, the satisfaction of the availability of the work facilities, difficulties they face when interacting with supervisors and colleagues as well as with clients at work.

Design/methodology/approach
A descriptive analytical approach has been used through designing a questionnaire aimed to examine the study dimensions. A random convenient sample of 306 women with disabilities was chosen. Data were analyzed using SPSS software.

Findings
Analysis revealed that the overall level of human resource management difficulties in the Jordanian public sector as perceived by women with disabilities was moderate (mean = 3). The participants reported a moderate level of assessment (mean = 2.80) about the availability of the work facilities. In addition, they showed a moderate level of satisfaction about both the treatment they receive from supervisors and colleagues as well as from clients with mean values of 2.85 and 2.91, respectively. The participants with physical disability and who hold administrative jobs reported higher level of difficulties of human resources management. Data showed that about 82% of women with disabilities were hired based on a social/humanitarian base instead of merit system.

Practical implications
This study has a significant practical contribution in providing information that will help policy makers and human resource managers to identify job-related difficulties and develop policies and programs to alleviate them to provide a better work environment to integrate employees with disabilities.

Originality/value
This study has a crucial value in filling the knowledge gap in examining the work-life of persons with disabilities in Jordan and in the Arab world.
Assessing the feasibility of blockchain technology in industries: evidence from Turkey
Authors: Erol Ismail , Ar Ilker Murat , Ozdemir Ali Ihsan , Peker Iskender , Asgary Ali , Medeni Ihsan Tolga , Medeni Tunc 
Published: May 2020

PurposeThe objective of this study is to assess quantitatively how feasible blockchain is for various industries, such as logistics and supply chain, health, energy, finance, automotive, pharmaceutical and agriculture and food using a comprehensive list of indicators.Design/methodology/approachA decision aid was applied to the problem of identifying the feasibility of blockchain in Turkish industries. To this end, first, a set of indicators was identified. Then, the fuzzy AHP and fuzzy TOPSIS were utilized to assess the feasibility comparatively using the data gathered from a group of experts. Finally, a scenario analysis was conducted to ensure the consistency of our evaluation.FindingsThe findings of this study suggest that comparatively, logistics and supply chain, finance and health industries are the most feasible industries for blockchain. This study further suggests that blockchain is the least feasible for the automotive industry compared to the rest of the identified industries.Research limitations/implicationsIt is cumbersome to find out the respondents who have sufficient knowledge of both blockchain and the identified industries. Even if we took the utmost care in identifying the right respondents, we limited our search to the biggest industrial hubs of Turkey.Practical implicationsThe findings of this research may help various decision-makers employed in governments, conglomerates, software and consulting firms and national research institutions make more informed decisions and allocate their resources more effectively.Originality/valueTo this date, the current studies have solely investigated possible research opportunities in blockchain and demonstrated several blockchain applications in stand-alone cases. To the best of our knowledge, however, no single study exists that evaluates the feasibility of blockchain comparatively and holistically among a group of industries using various indicators.
Mapping post-diagnostic dementia care in England: an e-survey
Authors: Frost Rachael , Walters Kate , Wilcock Jane , Robinson Louise , Harrison Dening Karen , Knapp Martin , Allan Louise , Rait Greta 
Published: May 2020

PurposePost-diagnostic dementia care is often fragmented in the United Kingdom, with great variation in provision. Recent policies suggest moving towards better community-based care for dementia; however, little is known on how this care is delivered. This study aimed to map the post-diagnostic dementia support provided in England a decade after the introduction of a National Dementia Strategy.Design/methodology/approachA mixed-methods e-survey (open Nov 2018–Mar 2019) of dementia commissioners in England recruited through mailing lists of relevant organisations was conducted. The authors descriptively summarised quantitative data and carried out thematic analysis of open-ended survey responses.Findings52 completed responses were received, which covered 82 commissioning bodies, with representation from each region in England. Respondents reported great variation in the types of services provided. Information, caregiver assessments and dementia navigation were commonly reported and usually delivered by the voluntary sector or local authorities. Integrated pathways of care were seen as important to avoid overlap or gaps in service coverage. Despite an increasingly diverse population, few areas reported providing dementia health services specifically for BME populations. Over half of providers planned to change services further within five years.Practical implicationsThere is a need for greater availability of and consistency in services in post-diagnostic dementia care across England.Originality/valuePost-diagnostic dementia care remains fragmented and provided by a wide range of providers in England.