bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antihelical Auricular Reconstruction With Adipoperichondrial Turnover Flap and Full-thickness Skin Graft
Authors: Baek Sang Oon , Kim Jae Won , Rha Eun Young 
Published: December 2020

Abstract
Reconstruction of the antihelical area can be challenging because the cartilage can be easily exposed due to the thin overlying soft tissue, and it has a lack of tissue mobility. Skin graft can be hesitant to perform in antihelical defects where the bare cartilage is exposed.
A 70-year-old male with squamous cell carcinoma of the antihelix of the left ear was referred to our department for surgical excision. Wide excision with tumor-free margins resulted in a defect of 2.0 × 1.0 cm with exposed bare cartilage. The authors covered the defect using adipoperichondrial turnover flap from cephalic portion of the earlobe followed by full thickness skin graft. The skin graft took well with no complication. Aesthetic result was satisfactory with no auricular deformity.
This adipoperichondrial turnover flap is simple, easy, can be performed in one stage, and produces good esthetic results with no disfiguration of the ear shape.
Dominance of the Leptoprosopic Face and Mesorrhine Nose Types: Does Stature and Facial Types Matter in Northern Nigerian Adults?
Authors: Obaje Sunday Godwin , Ibegbu Austine Oseloka 
Published: December 2020

Introduction:
World scientists are using facial morphometry as a reconstructive option in the treatment of patients and ethnic differentiations. Hence, the authors aimed to study the naso-facial dimensions of northern population in Nigeria.

Materials and Methods:
About 500 subjects (Igede, n = 260 and Idoma, n = 240) were recruited from schools in the Benue-Plateau valley in 2014–2015 academic session. Notable parameters measured using vernier caliper were upper facial length, lower facial length, total facial indices, nasal length, nasal width, and nasal indices. Also, stature was measured to the nearest centimeters with stadiometer.

Result:
Taller Idoma males than Igede males (169.25 ± 8.92, 167.13 ± 8.99), and taller Igede females than Idoma females (164.57 ± 8.77, 163.45 ± 8.94). The mean facial indices of Idoma subjects showed 97.89 ± 8.53 and 97.82 ± 8.11 with nasal indices of 77.77 ± 7.34 and 80.42 ± 7.53, whereas Igede subjects showed 96.88 ± 8.61: 97.83 ± 8.36 with nasal indices of 75.59 ± 7.45 and 77.55 ± 0.21. Both ethnic groups showed dominance of the leptoprosopic face type and mesorrhine nose type. All R2 values appeared to be above 0.5% (P < 0.05), where Igede males and females were 0.72, 0.71: 0.82, 0.81, and 0.69, 0.65 and 0.72, 0.73 for stature with total facial indices, and nasal indices respectively.

Conclusions:
Facial and nasal types serve as good predictors of stature, important for dimorphic and ethnic classifications in time of forensic needs.
Neurological Disorders associated with COVID-19 Hospital Admissions : Experience of a Single Tertiary Healthcare Centre
Authors: Dhillon Permesh Singh , Dineen Robert A. , Morris Haley , Tanasescu Radu , Nikfekr Esmaeil , Evans Jonathan , Constantinescu Cris S. , Hosseini Akram A. 
Published: December 2020

AbstractBackgroundEarly reports have detailed a range of neurological symptoms in patients with the SARS-CoV-2 infection. However, there is a lack of detailed description and incidence of the neurological disorders amongst hospitalized COVID-19 patients. We describe a range of neurological disorders (other than non-specific neurological symptoms), including their clinical, radiological and laboratory findings, encountered in our cohort of COVID-19 patients admitted to a large tertiary institution.MethodsWe reviewed our prospectively collated database of all adult Neurology referrals, Neurology and Stroke admissions and Neurological multi-disciplinary team meetings for all hospitalized patients with suspected or proven COVID-19 from 17 March 2020 to 31 August 2020.ResultsTwenty-nine of 1243 COVID-19 inpatients (2.3%) presented with COVID-19-related neurological disorders. The mean age was 68.9 +/- 13.5(SD) years, age range of 34-97 years, and there were 16 males. 22 patients had confirmed, 5 were probable and 2 had suspected COVID-19 infection according to the WHO case classification. Eight patients (27%) required critical care admission. Neurological symptoms at presentation included acute confusion and delirium, seizures, and new focal neurological deficits. Based on the pre-defined neurological phenotype, COVID-19 patients were grouped into four main categories. 16 patients had cerebrovascular events (13 with acute ischaemic stroke and 3 had haemorrhagic features), 7 patients were found to have inflammatory, non-inflammatory and autoimmune encephalopathy (including 2 with known Multiple Sclerosis), whilst disorders of movement and peripheral nervous system were diagnosed in 3 patients each.ConclusionAlthough the exact prevalence and aetiology remain unclear, new onset of neurological disorders, in addition to anosmia, is non-sporadic during the acute COVID-19-infection. Longitudinal follow-up of these patients is required to determine the clinical and functional outcome, treatment response and long-term effects of the SARS-CoV-2 infection.
AYUSH medicine as add-on therapy for mild category COVID-19; an open label randomised, controlled clinical trial
Authors: Rao Anusha , Ranganatha R , Vikneswaran G , Sagar C , Mathu R , Sherin M , sigamani Alben , Reddy M. Ravi Kumar 
Published: December 2020

AbstractBackgroundAYUSH formulations have a potential role in symptomatic treatment, preventing disease progression and improving quality of life in COVID-19 patients.ObjectiveTo study the effect of AYUSH formulation (Kabasura Kudineer tablets, Shakti drops and Turmeric plus) as an add-on treatment in patients with mild COVID - 19MethodologySingle centre, two arms, open labelled randomized controlled trial with a total of 30 patients (15 in the intervention arm and 15 in the standard care arm). Intervention arm received a combination of 3 AYUSH formulation along with the standard of care treatment for 21 days. All patients were followed for 28 days. Symptom severity (using Modified Jackson scale), negative conversion of SARS-CoV-2 RNA (using RTPCR) and quality of life (WHOWOL BREF questionnaire) was assessed.ResultsFifteen patients (93.8%) in the intervention group and twelve patients (92.3%) in the standard care arm had complete resolution of symptoms (P value= 0.36). Negative conversion for SARS-CoV-2 was seen in thirteen patients (92.9%) in intervention arm and eleven patients (100%) in standard care arm at day 28 (P value = 0.56). There was no difference in the quality of life scores between the 2 groups.ConclusionThe use of Ayush interventions as add-on therapy did not negatively impact the clinical outcomes in COVID-19. This trial confirmed the safety and tolerability of Kabasura Kudineer tablets, Shakti drops and Turmeric plus tablets when used use among mild to moderate symptom category, of COVID-19. There were no serious adverse events in the treated group. There was no clinical progression of disease from baseline status and all trial participants recovered fully by day 28. A longer follow up and a larger sample size is recommended for future definitive trials with this alternative medicine (AYUSH) combination.
Management of the Covid-19 Health Crisis: A Survey in Swiss Hospital Pharmacies
Authors: Schumacher Laurence , Dhif Yassine , Bonnabry Pascal , Widmer Nicolas 
Published: December 2020

ABSTRACTBackgroundThe COVID-19 pandemic has put a lot of strain on health systems since 2020. A review of the Swiss hospital pharmacies responses during the first wave was performed to improve the quality of the pharmaceutical management of future health crises.MethodsAn electronic survey was sent to all head of hospital pharmacies in Switzerland. The questionnaire was organized into eleven clusters of questions and covered many topics regarding the management of the first wave of COVID-19. Data collection was conducted from May to June, 2020.ResultsAnalyses were performed with 43 responses (66%) out of 65 questionnaires sent (at least one answer per questionnaire). 41% (17/41) of pharmacies had existing standard operating procedures or pandemic plans and 95% of them (39/41) created a steering committee to manage the crisis. 67% (29/43) created new activities to respond to the specific needs of the crisis. 67% (26/39) created new drug lists for: COVID-19-specific treatments (85% of pharmacies; 22/26), sedatives (81%; 21/26), anaesthetics (77%; 20/26) and antibiotics (73%; 19/26). Drug availability in COVID-19 wards was managed by increasing existing stocks (54% of pharmacies; 22/41) and creating extra storage space (51%; 21/41). Two drugs generated the most concern about shortages: propofol (49% of pharmacies; 19/39) and midazolam (44%; 17/39). Remdesivir stocks even ran out in 26% of pharmacies (10/39). Specific new documents were drafted to respond to medical needs with regards to drug administration (28% of pharmacies; 12/43), drug preparation (28%; 12/43) and treatment choices (23%; 10/43).ConclusionsSwiss hospital pharmacies encountered many challenges related to the COVID-19 crisis and had to find solutions quickly, effectively and safely. The survey highlights the key role played by Hospital Pharmacy’s in many aspects during the pandemic by providing logistical and clinical support to medical and care teams. The lessons and experiences outlined could be used to improve the quality of the preparation for similar future events.KEY POINTS▸The COVID-19 pandemic generated unprecedented global demand for specific drugs, hand sanitizer solution, and other therapeutic products, particularly in critical care settings, highlighting the essential role of hospital pharmacists in such crises.▸Key COVID-19 responses at the hospital pharmacy level included staff flexibility with regards to changes in roles and procedures, communication, teamwork and solidarity, and the need to prepare business continuity plans and management dashboards ▸ Managing and facing complex pandemic response reveals the importance of involving hospital pharmacists in pandemic response steering committees at many levels. The lived experiences during the pandemic could have been reviewed and evaluated to raise awareness and guide future policy responses for when the next crisis occurs.
Multimodal Data Acquisition at SARS-CoV-2 Drive Through Screening Centers: Setup Description and Experiences in Saarland, Germany
Authors: Flotho Philipp , Bhamborae Mayur J. , Grün Tobias , Trenado Carlos , Thinnes David , Limbach Dominik , Strauss Daniel J. 
Published: December 2020

AbstractSARS-CoV-2 drive through screening centers (DTSC) have been implemented worldwide as a fast and secure way of mass screening. We use DTSCs as a platform for the acquisition of multimodal datasets that are needed for the development of remote screening methods. Our acquisition setup consists of an array of thermal, infrared and RGB cameras as well as microphones and we apply methods from computer vision and computer audition for the contactless estimation of physiological parameters. We have recorded a multimodal dataset of DTSC participants in Germany for the development of remote screening methods and symptom identification. Acquisition in the early stages of a pandemic and in regions with high infection rates can facilitate and speed up the identification of infection specific symptoms and large scale data acquisition at DTSC is possible without disturbing the flow of operation.
Declining HIV incidence in sub-Saharan Africa: a systematic review and meta-analysis of empiric data
Authors: Joshi Keya , Lessler Justin , Olawore Oluwasolape , Loevinsohn Gideon , Bushey Sophrena , Tobian Aaron A.R. , Grabowski M. Kate 
Published: December 2020

ABSTRACTBackgroundUNAIDS models suggest HIV incidence is declining in sub-Saharan Africa; however, it is unclear whether modeled trends are supported by empirical evidence.MethodsWe conducted a systematic review and meta-analysis of adult HIV incidence data from sub-Saharan Africa by searching Embase, Scopus, PubMed, and OVID databases and technical reports published between January 1, 2010 and July 23, 2019. We included studies that directly measured incidence from blood samples. Incidence data were abstracted according to population risk group, geographic location, sex, intervention arm, and calendar period. Weighted regression models were used to assess incidence trends across general population studies by sex. We also identified studies reporting ≥3 incidence measurements since 2010 and assessed trends within them.Findings292 studies met inclusion criteria. Most studies were conducted in South Africa (n=102), Uganda (n=46), and Kenya (n=41); there were 27 countries with no published incidence data, most in western and central Africa. Across general population studies, average annual incidence declines since 2010 were 0.16/1000 person-years (95%CI:0.06-0.26;p=0.004) among men and 0.16/1000 person-years (95%CI: −0.01-0.33;p=0.060) among women in eastern Africa, and 0.25/1000 person-years (95%CI:0.17-034;p<0.0001) among men and 0.42/1000 person-years (95%CI:0.23-0.62;p=0.0002) among women in southern Africa. In 9/10 studies with multiple measurements, incidence declined over time. Incidence was typically higher in women than men (median ratio=1.45, IQR: 1.12-1.83) with increasing sex disparity over time.InterpretationEmpirical incidence data show the rate of new HIV infections is declining in eastern and southern Africa. However, recent incidence data are non-existent or very limited for many countries, particularly in western and central Africa.FundingNational Institute of Allergy and Infectious Diseases
The impact of the COVID-19 pandemic on college students’ health and financial stability in New York City: Findings from a population-based sample of City University of New York (CUNY) students
Authors: Jones Heidi E. , Manze Meredith , Ngo Victoria , Lamberson Patricia , Freudenberg Nicholas 
Published: December 2020

AbstractUnderstanding the effect of the coronavirus disease 2019 (COVID-19) pandemic on students’ health and financial stability is important to establish effective interventions to mitigate these effects, which may have long-term consequences on their health and wellbeing. Public universities in urban centers represent a substantial proportion of college students in the United States. We implemented a cross-sectional population-based online survey of 2,282 students in a large, public university in New York City in April 2020. We created weights to account for non-response and used Poisson regression with robust standard errors to estimate adjusted prevalence ratios (aPR) for factors associated with mental health outcomes. Students experienced high rates of anxiety/depression and financial instability due to the pandemic. Half of the students reported anxiety/depression (54.5%) and an increased need for mental health services (49.0%) as a result of the COVID-19 pandemic. The majority (81.1%) reported loss of household income, and half (49.8%) reported worries about losing housing. High levels of food (aPR=1.4, 95% CI 1.2, 1.6) and housing (aPR=1.3, 95% CI 1.2, 1.4) insecurity were the strongest predictors of anxiety/depression. Household and personal experiences with possible COVID-19 symptoms were also associated with anxiety/depression or the need for increased mental health services. Addressing student needs at public urban universities requires an integrated holistic approach that targets urgent mental health and economic needs related to the impact of COVID-19. Students who become infected need mental health services as well as health monitoring.
Multivariate Analysis Of Histopathological And Immunohistochemical Prognostic Factors In Endometrial Carcinoma. A Retrospective Pilot Study Of An Italian Regional Referral Center
Authors: Paudice Michele , Scaglione Giulia , Biatta Chiara Maria , Barra Fabio , Riva Marianna , Spina Bruno , Gaggero Gabriele , Fulcheri Ezio , Ferrero Simone , Vellone Valerio Gaetano ,   Gyn DMT
Published: December 2020

AbstractBackgroundto investigate endometrial carcinoma prognostic value of some histopathological and immunohistochemical factors, fairly easily accessible in every routinely pathology lab set.Methodswe considered patients affected by endometrial carcinoma with available clinical and radiological follow-up data after radical hysterectomy (S. Martino Polyclinic Hospital, Genoa, Italy, period 1/1/2013 - 1/7/2016). We analyzed the following histopathological items: histotype, stage (FIGO), type of infiltration (infiltrative/espansive), desmoplasia, intratumoral necrosis, tumor infiltrating lymphocytes and lymph vascular spaces invasion. Moreover, each case has been investigated with a panel of immunohistochemistry including estrogen receptor α, progesteron receptor, Ki67, p53, β-catenin, e-cadherin, bcl-2 and cyclin D1. Primary endpoints were disease free survival and overall survival.Resultsout of 99 cases eligible for our purpose, we found 69 low-grade endometrioid, 8 high-grade endometrioid and 22 other high-grade endometrial carcinomas. Disease free survival multivariate analysis showed a strong significant correlation between poor prognosis and advanced stage (p=0.0042). Advanced stage (p=0.0003) and presence of desmoplasia (p=0.04) resulted significantly correlated to a worse prognosis in overall survival multivariate analysis. In univariate model, the non-endometrioid histotype was significantly correlated with an unfavorable prognosis when compared to the endometriod type. Same for progesteron receptor low expression.Conclusionthe multivariate analysis confirmed the central prognostic role of stage in endometrial carcinoma. Moreover, other immunohistochemical markers in univariate analysis, have confirmed their easily reproducible usefulness, well integrating the recent TGCA molecular classification.
Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcome
Authors: Roberts Ivayla , Muelas Marina Wright , Taylor Joseph M. , Davison Andrew S. , Xu Yun , Grixti Justine M. , Gotts Nigel , Sorokin Anatolii , Goodacre Royston , Kell Douglas B. 
Published: December 2020

AbstractThe diagnosis of COVID-19 is normally based on the qualitative detection of viral nucleic acid sequences. Properties of the host response are not measured but are key in determining outcome. Although metabolic profiles are well suited to capture host state, most metabolomics studies are either underpowered, measure only a restricted subset of metabolites, compare infected individuals against uninfected control cohorts that are not suitably matched, or do not provide a compact predictive model.Here we provide a well-powered, untargeted metabolomics assessment of 120 COVID-19 patient samples acquired at hospital admission. The study aims to predict the patient’s infection severity (i.e., mild or severe) and potential outcome (i.e., discharged or deceased).High resolution untargeted LC-MS/MS analysis was performed on patient serum using both positive and negative ionization modes. A subset of 20 intermediary metabolites predictive of severity or outcome were selected based on univariate statistical significance and a multiple predictor Bayesian logistic regression model was created. The predictors were selected for their relevant biological function and include cytosine and ureidopropionate (indirectly reflecting viral load), kynurenine (reflecting host inflammatory response), and multiple short chain acylcarnitines (energy metabolism) among others.Currently, this approach predicts outcome and severity with a Monte Carlo cross validated area under the ROC curve of 0.792 (SD 0.09) and 0.793 (SD 0.08), respectively. A blind validation study on an additional 90 patients predicted outcome and severity at ROC AUC of 0.83 (CI 0.74 – 0.91) and 0.76 (CI 0.67 – 0.86). Prognostic tests based on the markers discussed in this paper could allow improvement in the planning of COVID-19 patient treatment.
GOLIATH regulates LDLR availability and plasma LDL cholesterol levels
Authors: Clifford Bethan L. , Jarrett Kelsey E. , Cheng Joan , Cheng Angela , Seldin Marcus , Morand Pauline , Lee Richard , Baldan Angel , de Aguiar Vallim Thomas Q. , Tarling Elizabeth J. 
Published: December 2020

AbstractIncreasing the availability of hepatic low-density lipoprotein receptors (LDLR) remains a major clinical target for reducing circulating plasma LDL cholesterol (LDL-C) levels. Here, we identify the molecular mechanism underlying genome-wide significant associations in theGOLIATHlocus with plasma LDL-C levels. We demonstrate that GOLIATH is an E3 ubiquitin ligase that ubiquitinates the LDL Receptor resulting in redistribution away from the plasma membrane. Overexpression of GOLIATH decreases hepatic LDLR and increases plasma LDL-C levels. Silencing ofGoliathusing antisense oligonucleotides, germline deletion, or AAV-CRISPRin vivostrategies increases hepatic LDLR abundance and availability, thus decreasing plasma LDL-C.In vitroubiquitination assays demonstrate RING-dependent regulation of LDLR abundance at the plasma membrane. Our studies identify GOLIATH as a novel post-translational regulator of LDL-C levels via modulation of LDLR availability, which is likely important for understanding the complex regulation of hepatic LDLR.
A novelRLIM/RNF12variant disrupts protein stability and function to cause severe Tonne-Kalscheuer syndrome
Authors: Bustos Francisco , Espejo-Serrano Carmen , Segarra-Fas Anna , Eaton Alison J. , Kernohan Kristin D. , Wilson Meredith J. , Riley Lisa G. , Findlay Greg M. 
Published: December 2020

ABSTRACTTonne-Kalscheuer syndrome (TOKAS) is an X-linked intellectual disability syndrome associated with variable clinical features including craniofacial abnormalities, hypogenitalism and diaphragmatic hernia. TOKAS is caused exclusively by variants in the gene encoding the E3 ubiquitin ligase geneRLIM, also known as. Here we report identification of a novelRLIMmissense variant, c.1262A>G p.(Tyr421Cys) adjacent to the regulatory basic region, which causes a severe form of TOKAS resulting in perinatal lethality by diaphragmatic hernia. Inheritance and X-chromosome inactivation patterns implicateRLIMp.(Tyr421Cys) as the likely pathogenic variant in the affected individual and within the kindred. We show that the RLIM p.(Tyr421Cys) variant disrupts both expression and function of the protein in an embryonic stem cell model. RLIM p.(Tyr421Cys) is correctly localised to the nucleus, but is readily degraded by the proteasome. The RLIM p.(Tyr421Cys) variant also displays significantly impaired E3 ubiquitin ligase activity, which interferes with RLIM function inXistlong-non-coding RNA induction that initiates imprinted X-chromosome inactivation. Our data uncover a highly disruptive missense variant inRLIMthat causes a severe form of TOKAS, thereby expanding our understanding of the molecular and phenotypic spectrum of disease severity.