bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fibroblast growth factor 10 is a negative regulator of postnatal neurogenesis in the mouse hypothalamus
Authors: Goodman Timothy , Nayar Stuart G. , Clare Shaun , Mikolajczak Marta , Rice Ritva , Mansour Suzanne , Bellusci Saverio , Hajihosseini Mohammad K. 
Published: July 2020

ABSTRACT
New neurons are generated in the postnatal rodent hypothalamus, with a subset of tanycytes in the third ventricular (3V) wall serving as neural stem/progenitor cells. However, the precise stem cell niche organization, the intermediate steps and the endogenous regulators of postnatal hypothalamic neurogenesis remain elusive. Quantitative lineage-tracing in vivo revealed that conditional deletion of fibroblast growth factor 10 (Fgf10) from Fgf10-expressing β-tanycytes at postnatal days (P)4-5 results in the generation of significantly more parenchymal cells by P28, composed mostly of ventromedial and dorsomedial neurons and some glial cells, which persist into adulthood. A closer scrutiny in vivo and ex vivo revealed that the 3V wall is not static and is amenable to cell movements. Furthermore, normally β-tanycytes give rise to parenchymal cells via an intermediate population of α-tanycytes with transient amplifying cell characteristics. Loss of Fgf10 temporarily attenuates the amplification of β-tanycytes but also appears to delay the exit of their α-tanycyte descendants from the germinal 3V wall. Our findings suggest that transience of cells through the α-tanycyte domain is a key feature, and Fgf10 is a negative regulator of postnatal hypothalamic neurogenesis.
Disc-associated proteins mediate the unusual hyperstability of the ventral disc in Giardia lamblia
Authors: Nosala Christopher , Hagen Kari D. , Hilton Nicholas , Chase Tiffany M. , Jones Kelci , Loudermilk Rita , Nguyen Kristofer , Dawson Scott C. 
Published: July 2020

ABSTRACT
Giardia lamblia, a widespread parasitic protozoan, attaches to the host gastrointestinal epithelium by using the ventral disc, a complex microtubule (MT) organelle. The ‘cup-like’ disc is formed by a spiral MT array that scaffolds numerous disc-associated proteins (DAPs) and higher-order protein complexes. In interphase, the disc is hyperstable and has limited MT dynamics; however, it remains unclear how DAPs confer these properties. To investigate mechanisms of hyperstability, we confirmed the disc-specific localization of over 50 new DAPs identified by using both a disc proteome and an ongoing GFP localization screen. DAPs localize to specific disc regions and many lack similarity to known proteins. By screening 14 CRISPRi-mediated DAP knockdown (KD) strains for defects in hyperstability and MT dynamics, we identified two strains – DAP5188KD and DAP6751KD –with discs that dissociate following high-salt fractionation. Discs in the DAP5188KD strain were also sensitive to treatment with the MT-polymerization inhibitor nocodazole. Thus, we confirm here that at least two of the 87 known DAPs confer hyperstable properties to the disc MTs, and we anticipate that other DAPs contribute to disc MT stability, nucleation and assembly.
Pseudohyphal growth in Saccharomyces cerevisiae involves protein kinase-regulated lipid flippases
Authors: Frøsig Merethe Mørch , Costa Sara Rute , Liesche Johannes , Østerberg Jeppe Thulin , Hanisch Susanne , Nintemann Sebastian , Sørensen Helle , Palmgren Michael , Pomorski Thomas Günther , López-Marqués Rosa L. 
Published: July 2020

ABSTRACT
Lipid flippases of the P4 ATPase family establish phospholipid asymmetry in eukaryotic cell membranes and are involved in many essential cellular processes. The yeast Saccharomyces cerevisiae contains five P4 ATPases, among which Dnf3p is poorly characterized. Here, we demonstrate that Dnf3p is a flippase that catalyzes translocation of major glycerophospholipids, including phosphatidylserine, towards the cytosolic membrane leaflet. Deletion of the genes encoding Dnf3p and the distantly related P4 ATPases Dnf1p and Dnf2p results in yeast mutants with aberrant formation of pseudohyphae, suggesting that the Dnf1p–Dnf3p proteins have partly redundant functions in the control of this specialized form of polarized growth. Furthermore, as previously demonstrated for Dnf1 and Dnf2p, the phospholipid flipping activity of Dnf3p is positively regulated by flippase kinase 1 (Fpk1p) and Fpk2p. Phylogenetic analyses demonstrate that Dnf3p belongs to a subfamily of P4 ATPases specific for fungi and are likely to represent a hallmark of fungal evolution.
Water-Phase Synthesis of Ultrathin Au Nanowires with a Two-Dimensional Parallel Array Structure
Authors: Miyajima Naoya , Wang Yung-Chen , Nakagawa Makoto , Kurata Hiroki , Imura Yoshiro , Wang Ke-Hsuan , Kawai Takeshi 
Published: July 2020

Abstract
Ultrathin Au nanowires (NWs) with a diameter below 2 nm have attracted considerable attention as a promising one-dimensional nanomaterial. However, they are practically synthesized in organic solvents. Here, for the first time, we report the synthesis of ultrathin Au NWs with ∼1.7 nm diameter in water using a water-soluble long-chain amidoamine derivative (C18AA) as a key compound. The resultant Au NWs were naturally dispersible in water, which is an environment-friendly solvent. We also demonstrate that the formation of the Au NWs is based on oriented-attachment growth mechanism, and that the presence of Cl− ion facilitates its effective elongation over a length of a few µm. Further, cryogenic transmission electron microscopy (cryo-TEM) of the aqueous dispersion revealed that the Au NWs self-assembled into a bundle structure with two-dimensional parallel arrays in water.
Customer Supercharging in Experience-Centric Channels
Authors: Bell David R. , Gallino Santiago , Moreno Antonio 
Published: July 2020

We conjecture that for online retailers, experience-centric offline store formats do not simply expand market coverage, but rather, serve to significantly amplify future positive customer behaviors, both online and offline. We term this phenomenon “supercharging” and test our thesis using data from a digital-first men’s apparel retailer and a pioneer of the so-called zero inventory store (ZIS) format—a small-footprint, experience-centric retail location that carries no inventory for immediate fulfillment, but fulfils orders via e-commerce. Using a risk-set matching approach, we calibrate our estimates on customers who are “treated,” that is, have a ZIS experience, and matched with identical customers who shop online only. We find that after the ZIS experience, customers spend more, shop at a higher velocity, and are less likely to return items. The positive impact on returns is doubly virtuous as it is more pronounced for more tactile, higher-priced items, thus mitigating a key pain point of online retail. Furthermore, the ZIS shopping experience aids product discovery and brand attachment, causing sales to become more diffuse over a larger number of categories. Finally, we demonstrate that our results are robust to self-selection and potentially confounding effects of unobservable factors on the matched pairs of customers. Implications for retailing practice, including for legacy, offline-first retailers, are discussed. This paper was accepted by Victor Martínez-de-Albéniz, operations management.
Relationship between World Assumptions and Resilience in Psychological Counsellors: The Mediating Role of Self-Orientations
Authors: Erden-Cinar Seval 
Published: July 2020

<p style="text-align:justify">The purpose of the study was to examine the mediating role of self-orientations in the relationship between resilience and world assumptions of psychological counsellors. A total of 321 psychological counsellors, were recruited and 211 of them were women and 110 of them were men. The ages of the participants ranged from 23 to 52. The Brief Resilience Scale, World Assumptions Scale, and Balanced Integration-Differentiation (BID) Scale were used as data collection tools. In the analysis of the data, descriptive statistics, Pearson Correlation Coefficient, as well as the Bootstrap method was used to analyze the mediation effects. The findings showed that the assumptions of benevolence, randomness, self-worth, and justice and self-orientation were positively related to psychological resilience. Results of the mediation analysis revealed that self-developmental and interrelational orientations had mediation effects on relationships between world assumptions and resilience as in the proposed model. Findings for the model tested in the study were discussed with the literature and the implications were given to field experts, researchers, and psychological counsellors.</p>
8 × 8 SOA-based optical switch with zero fiber-to-fiber insertion loss
Authors: Mojaver Hassan Rahbardar , Tolstikhin Valery , Gargallo Bernardo , Baños Rocio , Domenech David , Lo Jessica , Kumar Dhiraj , Leong Kin-Wai , Liboiron-Ladouceur Odile 
Published: July 2020

The design, fabrication, and characterization of an

8

×

8

lossless optical switch, based on semiconductor optical amplifier (SOA) gates, is reported. It comprises three stages of

2

×

2

switches into an

8

×

8

Banyan switch, for a total of 48 SOAs. Three SOAs on each optical path provide gain to compensate for on-chip and fiber coupling loss, thereby making the optical switch lossless. All 64 optical paths demonstrate error-free 10 Gbps NRZ PRBS-31 transmission with at least 30 dB signal-to-noise ratio and less than 0.9 dB power penalty.
High sensitivity demodulation of a reflective interferometer-based optical current sensor using an optoelectronic oscillator
Authors: Wang Muguang , Zhang Naihan , Huang Xiaodi , Yin Bin , Mu Hongqian , Han Mengyao , Chen Desheng 
Published: July 2020

A novel, to the best of our knowledge, interrogation scheme based on an optoelectronic oscillator (OEO) with high sensitivity and high speed response for a fiber optical current sensor utilizing a reflective interferometer is proposed and experimentally demonstrated. Due to the Faraday effect, a magneto-optic phase shift induced by current variation is generated between two orthogonal light waves. The polarization-dependent properties of the Mach–Zehnder modulator are used to convert the magneto-optic phase shift into the phase difference between the optical carrier and sideband, which is then mapped to the oscillating frequency shift by closing an OEO loop. A high current sensitivity of 152.5 kHz/A with a range of 0–2.5 A is obtained in the experiment.
Perubahan Garis Pantai di Perairan Muara Sungai Musi Hubunganya dengan Sedimentasi
Authors: Barus Beta Susanto , Ningsih Ellis Nurjuliasti , Melki Melki 
Published: July 2020

Musi Estuary is strongly influenced by various land activities such as plantations, industry, agriculture and others. These activities have a negative effect on the condition of these waters, one of which is sedimentation. Sedimentation is an important factor that must be considered during development such as port construction and reclamation. This study aims to analyzed the dynamics of shoreline changes in the Musi Estuary, South Sumatra associated with sediment characteristics and sedimentation rates in the area. This research was carried out by installing a sediment trap for 14 days. Trapped sediments were taken once a week and calculated the volume and rate of sediment accumulation. The results showed that the dominant sedimentary characteristics in Musi Estuary were dominated by clay and mud with sediment accumulation rates ranging from 86,63-97,97 mg/cm2/day. The results of the dynamics of shoreline changes in the form of abrasion at stations 2, 3, 4, 5 and 6 and sedimentation at Station 1. The highest land change by abrasion was found at station 6 with land changes ± 129, 83 meters in 5 years and land changes by sedimentation at station 1 with a reduction in land ± 13.31 meters in 5 years. Muara Sungai Musi merupakan perairan muara yang sangat dipengaruhi oleh berbagai aktivitas daratan seperti perkebunan, industri, pertanian dan lain-lain. Aktivitas tersebut memberikan efek negatif terhadap kondisi perairan tersebut, salah satunya adalah sedimentasi. Sedimentasi menjadi faktor penting yang harus diperhatikan pada saat melakukan pembangunan seperti pembangunan pelabuhan dan reklamasi. Penelitian ini bertujuan untuk menganalisis dinamika perubahan garis pantai di Perairan Muara Musi, Sumatera Selatan dikaitkan dengan karakteristik sedimen dan laju sedimentasi di daerah tersebut. Penelitian ini dilakukan pada bulan November 2019 dan pengambilan sampel dilakukan dengan memasang sedimen trap selama 14 hari. Sedimen yang terperangkap diambil seminggu sekali dan dihitung volume dan laju akumulasi sedimen. Hasil penelitian menunjukkan bahwa karakteristik sedimen yang dominan di Muara Musi didominasi oleh tanah liat dan lumpur dengan tingkat akumulasi sedimen berkisar antara 86,63-97,97 mg/cm2/hari. Hasil dinamika perubahan garis pantai dalam bentuk abrasi di stasiun 2, 3, 4, 5 dan 6 dan sedimentasi di stasiun 1. Perubahan lahan oleh abrasi tertinggi ditemukan di stasiun 6 dengan perubahan lahan ±129,83 meter dalam 5 tahun dan perubahan lahan oleh sedimentasi di stasiun 1 dengan pengurangan lahan ±13,31 meter dalam 5 tahun.
Dampak Lingkungan dan Kesehatan Pemanfaatan Limbah Cat Sebagai Produk Material Bangunan
Authors: Citra Ari Dina Permana , Iswandari Hargianti Dini 
Published: July 2020

Limbah cat yang tidak mempunyai nilai ekonomis dan memerlukan biaya untuk pengolahannya, dapat dimanfaatkan sebagai bahan baku menjadi produk yang berguna. Limbah cat digunakan sebagai bahan baku campuran pembuatan produk bata beton (paving block) agar dapat mencegah dampak negative lingkungan. Penelitian yang dilakukan bertujuan untuk mengkaji dampak lingkungan dan kesehatan dari limbah cat dan pemanfaatannya sebagai campuran bata beton. Dampak lingkungan sebagai ekotoksisitas dan dampak kesehatan berupa toksisitas dihitung menggunakan perangkat kajian daur hidup LCA (Life Cycle Assessment) pada variasi kadar limbah cat sebesar 1,2,3,4 dan 5% pada bata beton. Hasil kajian menunjukkan penurunan potensi dampak lingkungan dan kesehatan produk bata beton dibandingkan limbah cat padat. Ekotoksisitas limbah cat terendah pada media tanah dan tertinggi pada media perairan air tawar. Toksisitas pada manusia jauh lebih tinggi dibanding pada media lingkungan, dipakai sebagai dasar penanganan limbah cat. Pemanfaatan limbah cat sebagai bahan baku campuran bata beton dapat mengurangi ekotoksisitas dan toksisitas secara signifikan, dapat digunakan sebagai model pengelolaan limbah. Paint waste that has no economic value and requires a cost for its processing can be used as raw material to become a useful product. Waste paint is used as a raw material for the manufacture of concrete brick products (paving blocks) in order to prevent negative environmental impacts. The research carried out aims to assess the environmental and health impacts of paint waste and its use as a concrete brick mixture. Environmental impacts as ecotoxicity and health impacts in the form of toxicity are calculated using the LCA (Life Cycle Assessment) life cycle assessment tool on the variation of paint waste content of 1,2,3,4 and 5% in concrete bricks. The results of the study show a decrease in the potential environmental and health impacts of concrete brick products compared to solid paint waste. The lowest paint waste ecotoxicity in soil media and highest in freshwater waters media. Toxicity in humans is much higher than in environmental media, used as a basis for handling paint waste. The use of paint waste as raw material for concrete brick mix can significantly reduce the ecotoxicity and toxicity, it can be used as a waste management model.
What does translanguaging-for-equity really involve? An interactional analysis of a 9th grade English class
Authors: Mendoza Anna 
Published: July 2020

Abstract
While much research on translanguaging is in bilingual and heritage language classrooms, it is under-researched in K-12 English-medium education. To better understand translanguaging in this context, this study applied interactional sociolinguistics, including analytical categories adapted from Conversation-for-Learning (Kasper and Kim, 2015; Kim, 2019), to a ninth grade English class in Honolulu with students from diverse linguistic backgrounds. The study examined interactional sequences as students did literary analysis of novels and poetry over 13 weeks. These sequences involved appropriation of others’ lexical phrases, collaborative word searches, miscommunication repair, and knowledge checks. Translanguaging, when it occurred, indicated joint meaning-making across linguistic asymmetries, and was not only a means of thinking aloud using an integrated language repertoire, but a form of helping peers as students signaled to each other to adopt language, teach them something, or work through a problem together, creating opportunities to learn. These findings suggest that equity hinges not only on allowing students to learn using their whole linguistic repertoires but on social and ethical dispositions made apparent through interactional analyses.
The special atom space and Haar wavelets in higher dimensions
Authors: Kwessi Eddy , de Souza Geraldo , Djitte Ngalla , Ndiaye Mariama 
Published: July 2020

AbstractIn this note, we will revisit the special atom space introduced in the early 1980s by Geraldo De Souza and Richard O’Neil. In their introductory work and in later additions, the space was mostly studied on the real line. Interesting properties and connections to spaces such as Orlicz, Lipschitz, Lebesgue, and Lorentz spaces made these spaces ripe for exploration in higher dimensions. In this article, we extend this definition to the plane and space and show that almost all the interesting properties such as their Banach structure, Hölder’s-type inequalities, and duality are preserved. In particular, dual spaces of special atom spaces are natural extension of Lipschitz and generalized Lipschitz spaces of functions in higher dimensions. We make the point that this extension could allow for the study of a wide range of problems including a connection that leads to what seems to be a new definition of Haar functions, Haar wavelets, and wavelets on the plane and on the space.
The potential for learning within hospital learning communities: the interplay between nursing practice and education to support research ability
Authors: Heemskerk Wendy M. , Warning Talitha D. , Brus Frank , Snoeren Miranda M. W. C. 
Published: July 2020

Abstract

Objectives
Nurses must contribute to the development of professional practice and thereby improve quality of care by using their research abilities. Therefore, learning communities comprised of nurses, students and teachers were created in a hospital.

Methods
A qualitative descriptive methodology was used. Three learning communities were purposefully selected, and members were asked open-ended questions about their learning and activities in multiple data collection sessions. Data were analyzed by means of an inductive process.

Results
Both individually and collectively, members learned about research in general, research terminology and methods. They learned about asking questions and critical thinking, and, specifically through collective learning, they learned about the differences between education practices. Activities were carried out primarily to continue personal learning.

Conclusions
Learning within the learning communities was mainly research-oriented and therefore potentially suitable for enhancing research ability. Implications are offered to support the formulation of community activities.
Transience and Tunnel Esperanto: A study of multilingualism, work and relationship-building on a tunnel mining project
Authors: Kraft Kamilla 
Published: July 2020

AbstractThis paper investigates multilingualism as language and communication discourses and practices in a Copenhagen metro tunnel construction project. This project is characterized by transience: continual time-space changes of work organization and staff relations combined. In this scenario, a highly international and multilingual staff composition puts focus on language and communication. Based on interviews with managers and workers from one of the project’s contractors, as well as observations of daily work in the tunnels, the analysis demonstrates participants’ discursive constructions oflanguageandcommunication, sometimes linking these concepts to work, sometimes to relationship-building. I argue that these constructions are closely interlinked with the workplace’s transient status and conditions, and draw out how they have empowering as well as exploitative implications for the workers.
Designing and validation of a yoga-based module for obesity with metabolic comorbidities
Authors: Chobe Meenakshi P. , Nanjundaiah Ramesh Mavathur , Chobe Shivaji 
Published: July 2020

Abstract

Objectives
Obesity is a condition of increased adipose tissue in the body, which is commonly associated with various comorbidities like diabetes, hypertension, arthritis, back pain, and many others. Yoga modules have been designed and validated for obesity; however, we couldn't find any specific module for metabolic syndrome, a condition which includes obesity, diabetes mellitus type 2 and/or hypertension together. Keeping this in view, our study aimed to develop and validate a specific generic yoga-based intervention module for metabolic syndrome patients.

Materials and methods
A yoga module was designed based on traditional and contemporary yoga literature as well as published studies. We derived the yoga practices for the module, from these yoga texts and research evidence were already available. The yoga module was sent to 40 yoga experts for their validation.

Results
Twenty-two experts gave their opinion on the usefulness of a yoga module for patients with metabolic syndrome with some suggestions. Of these experts, 73% were males, and 27% were females. Yoga therapy practices with content validity ratio (CVR) >0.08 were included in the final module. In total, 86% (31 of 36 items) of the items in the initial module were retained.

Conclusion
A specific yoga-based module for metabolic syndrome was designed and validated by experts. Further studies are needed to confirm the efficacy and clinical utility of the module.
Additional clinical validation is suggested.
Free space optics communication system design using iterative optimization
Authors: Lema Gebrehiwet Gebrekrstos 
Published: July 2020

Abstract
Free Space Optics (FSO) communication provides attractive bandwidth enhancement with unlicensed bands worldwide spectrum. However, the link capacity and availability are the major concern in the different atmospheric conditions. The reliability of the link is highly dependent on weather conditions that attenuate the signal strength. Hence, this study focuses to mitigate the weather and geographic effects using iterative optimization on FSO communication. The optimization maximizes the visibility distance while guaranteeing the reliability by minimizing the Bit Error Rate (BER). The wireless optical communication system is designed for the data rate of 10 Gbps. The performance of the proposed wireless optical communication is compared against the literature in terms of visibility distance, quality factor, BER, and Eye diagram at different atmospheric conditions. The simulation results have shown that the proposed work has achieved better performance.