bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cluster of Vacuolated Spinous Keratinocytes: A Clue to Cornoid Lamellation and a Case of Porokeratosis Disseminata
Authors: Keller Lauren P. , Halim Kareem , Abedi Syed M. , Liu Wentao , Gottesman Silvija P. 
Published: January 2020

Abstract:
Cornoid lamella is a definitive diagnostic feature of porokeratosis, a disorder of keratinization that has various different clinical presentations. A tiered column of parakeratosis and a diminished granular layer with dyskeratotic keratinocytes at the column base are all useful and known features of cornoid lamellation. We have found a cluster of vacuolated spinous cells to be a reliable fourth feature of cornoid lamellation and a feature when present alone to be a reliable sign of impending cornoid lamellation on deeper sections. Furthermore, we present a novel clinical phenotype of disseminated papular porokeratosis with effective clinical response to combination of phototherapy, oral and topical retinoids, and topical vitamin D derivative, which too contained all 4 features of cornoid lamellation.
Incidence of New Neuropsychiatric Disorder Diagnoses Following Traumatic Brain Injury
Authors: Albrecht Jennifer S. , Abariga Samuel A. , Rao Vani , Wickwire Emerson M. 
Published: January 2020

Background:
Neuropsychiatric disturbances (NPDs) are common following traumatic brain injury (TBI) and associated with poor recovery. Prior estimates of NPD following TBI failed to account for preexisting NPDs or potential confounding.

Methods:
We estimated the risk of anxiety, posttraumatic stress disorder (PTSD), bipolar disorder, and alcohol and substance dependence disorder diagnoses associated with TBI using administrative claims data from a large insurer in the United States, 2008-2014. We calculated rates of new NPD diagnoses during the 12 months before and 24 months after TBI and estimated the risk of NPD following TBI using a difference-in-difference approach and adjusting for confounders.

Results:
Before the TBI occurred, rates of NPD diagnoses were more than double in the TBI cohort (n = 207 354) relative to the no-TBI cohort (n = 414 708). TBI was associated with an increased risk of anxiety (rate ratio [RtR] = 1.08; 95% confidence interval [CI], 1.05-1.12) and PTSD (RtR = 1.41; 95% CI, 1.24-1.60) diagnoses. Rates of alcohol (RtR = 0.32; 95% CI, 0.30-0.34) and substance use disorder (RtR = 0.57; 95% CI, 0.55-0.59) diagnoses decreased following TBI.

Conclusions:
In this large national study, rates of NPD were much higher among individuals with TBI than those in a non-TBI cohort, even before the TBI took place. TBI was associated with an increased risk of anxiety and PTSD diagnoses. Results from this study also suggest that individuals who sustain TBI have increased contact with the healthcare system during the months prior to injury, providing a window for intervention, especially for individuals diagnosed with alcohol dependence disorder.
A Clinical Trial Investigating Telehealth and In-Person Social Communication Skills Training for People With Traumatic Brain Injury: Participant-Reported Communication Outcomes
Authors: Rietdijk Rachael , Power Emma , Attard Michelle , Heard Robert , Togher Leanne 
Published: January 2020

Objective:
To investigate the efficacy of telehealth-based and in-person social communication skills training (TBIconneCT) for people with moderate to severe traumatic brain injury (TBI) based on outcomes reported by the survivor and a close communication partner.

Setting:
Australia. Two telehealth dyads were located outside Australia.

Participants:
Adults (n = 51) at least 6 months after moderate-severe TBI with social communication skills deficits, and their usual communication partners (family members, friends, or paid carers).

Design:
Partially randomized controlled trial, with a telehealth intervention group, in-person intervention group, and a historical control group.

Main Measures:
La Trobe Communication Questionnaire (LCQ) (total score, and number of items with perceived positive change). Both self- and other-reports.

Results:
Trained participants had significantly more items with perceived positive change than did historical controls. A medium effect size in the sample was observed for improvements in total score reported by trained communication partners after treatment. Comparisons between telehealth and in-person groups found medium to large effect sizes in the sample, favoring the telehealth group on some LCQ variables.

Conclusions:
Whether delivered via telehealth or in-person, social communication skills training led to perceived positive change in communication skills. It was unexpected that outcomes for the telehealth group were better than for the in-person group on some variables.
Influence of Prior and Intercurrent Brain Injury on 5-Year Outcome Trajectories After Moderate to Severe Traumatic Brain Injury
Authors: Rabinowitz Amanda R. , Chervoneva Inna , Hart Tessa , O'Neil-Pirozzi Therese M. , Bogner Jennifer , Dams-O'Connor Kristen , Brown Allen W. , Johnson-Greene Doug 
Published: January 2020

Objective:
To characterize the influence of additional (both prior and subsequent) traumatic brain injuries (TBIs) on recovery after a moderate to severe index TBI.

Setting:
Traumatic Brain Injury Model Systems centers.

Participants:
Persons with moderate to severe TBI (N = 5054) enrolled in the TBI Model Systems National Database with complete outcome data for the outcomes of interest at 1-, 2-, and 5-year follow-up.

Design:
Secondary analysis of a prospective longitudinal data set.

Main Measures:
Prior and intercurrent TBI from the Ohio State University TBI Identification Method (OSU TBI-ID), Disability Rating Scale (DRS), and Functional Independence Measure (FIM).

Results:
Prior moderate-severe TBIs significantly predicted overall level of functioning on the DRS, FIM Cognitive, and FIM Motor for participants with less severe index injuries. Moderate-severe intercurrent TBIs (TBIs subsequent to the index injury) were predictive of poorer functioning for both Index Severity groups, reflected in higher mean scores on the DRS in participants with less severe index injuries and lower mean Cognitive FIM in participants with more severe index injuries.

Conclusion:
Multiple brain injuries, particularly those of moderate or greater severity, have a significantly greater impact on patients' level of functioning compared with a single injury, but not the rate or shape of recovery.
Comparative Effectiveness of Microprocessor-Controlled and Carbon-Fiber Energy-Storing-and-Returning Prosthetic Feet in Persons with Unilateral Transtibial Amputation: Patient-Reported Outcome Measures
Authors: Kaluf Brian , Duncan Ashley , Bridges William 
Published: January 2020

ABSTRACT

Introduction
Microprocessor ankles (MPAs) have recently been developed for persons with lower-limb amputation to overcome known limitations of fixed-ankle energy-storing-and-returning (ESAR) feet. This study aimed to examine differences in patient-reported balance, mobility, socket comfort, and preference between an ESAR foot and an MPA in persons with unilateral transtibial amputation (UTA).

Materials and Methods
Twenty-three participants with UTA enrolled in an institutional review board–approved, randomized crossover protocol with ESAR (Pacifica LP) and microprocessor-ankle configurations (Kinnex, Freedom Innovations) and a 4-week accommodation period. The outcome measures collected included Activities Specific Balance Confidence Scale (ABC), Prosthesis Evaluation Questionnaire–Mobility Subscale (PEQ-MS), and Prosthetic Limb User Survey of Mobility (PLUS-M). Participants were asked to rate Socket Comfort Score (SCS) while ascending and descending a 15° sloped ramp. Finally, ankle-foot preference and aspects liked and disliked about each configuration were recorded.

Results
Significant improvements were seen with the MPA in patient-reported mobility in the community (PEQ-MS, ρ = 0.0465) and socket comfort walking and standing on slopes (SCS, ρ < 0.001). Differences in balance confidence (ABC) did not reach a level of significance, whereas improvement in perceived mobility with a prosthesis approached a level of significance (PLUS-M, ρ = 0.102). When asked, 81% of participants preferred the MPA over the ESAR foot. Participants reported positively about the reduced weight of the ESAR foot, whereas they frequently reported that the MPA was better on slopes and uneven terrain.

Conclusions
The 30° range of motion in the MPA can allow greater mobility when ambulating on typical environmental barriers (e.g., uneven terrain, ramps, and stairs) and allow patients to stand and walk on slopes with less socket discomfort. Most participants preferred the MPA. Frequently reported positive and negative aspects of both systems may be useful for patient consultation regarding ankle-foot technology. This study represents the largest known investigation of MPAs, and the results provide evidence of benefits from MPAs over ESAR feet in persons with UTA.
Assessment of media reportage of monkeypox in southern Nigeria
Authors: Wogu Joseph Oluchukwu , Chukwu Christiana Ogeri , Orekyeh Emeka S.S. , Nwankiti Chukwuemeka Ononuju , Okoye-Ugwu Stella 
Published: January 2020

Abstract
Monkeypox is a zoonotic viral disease. Media campaigns are planned to create awareness about the disease. This is because mass media is often the leading source of information and mobilization during important health issues or crisis. The main objective of this study was to assess the media coverage of monkeypox outbreak in Nigeria.
The study adopted a cross-sectional survey of residents in Southern Nigeria. A total of 600 respondents were sampled for this study through a multi-stage cluster random sampling technique. Research assistants helped in collecting data from respondents through structured questionnaire. The data collected was analyzed using percentages, mean score, and univariate analysis of variance (ANOVA).
Respondents had little or no knowledge of monkeypox virus, its nature, mode of transmission, and prevention mechanism (2.30 ± .918, P
= .000). Respondents stated that they learnt about the virus through friends and social institutions instead of media (4.44 ± .945, P
= .006). Media failed to create effective and comprehensive awareness campaigns to mobilize the public (1.86 ± 1.196, P
= .001), while inappropriate and insufficient media programs and lack of funds were blamed for media ineffectiveness (4.18 ± 1.352, P
= .004).
The outbreak of monkeypox virus is a public health concern in Nigeria. Media campaigns are planned to raise awareness about the disease; however, these campaigns have not demonstrated effectiveness in changing people's health behavior toward monkeypox. Media, health professionals, and government should synergize to promote a consistent health policy for the control and prevention of monkeypox virus.
A long-term retrospective study on sporadic Burkitt lymphoma in chinese population
Authors: Yang Xiaoyun , Huang Qianru , Li An , Chen Yuan , Xu Wei , Li Jianyong , Wang Yaping , Fang Yongjun 
Published: January 2020

Abstract
Burkitt lymphoma (BL), an aggressive malignancy, brings a prognosis varying among children, adolescents, and adults. Most of previous retrospective studies of BL focused on a part of population. This study aimed to find the leading prognostic factors in BL among patients of different age groups. World Health Organization classification of lymphoid neoplasms in 2008 and revision in 2016 were used as diagnostic criteria for BL. We compared the laboratory results and clinical manifestations in 2 age groups by Kaplan–Meier survival analysis. Our study strongly indicated that age >14 years and lactate dehydrogenase >570 U/L were 2 powerful prognostic factors for BL. The results indicated that poor prognosis may be for the poor tolerance and low dose of drugs in adolescents and adults.
Epidemiology of low-energy wrist, hip, and spine fractures in Chinese populations 50 years or older
Authors: Zhu Yanbin , Xing Xin , Liu Song , Chen Wei , Zhang Xiaolin , Zhang Yingze 
Published: January 2020

Abstract
The aim of the study was to investigate the incidence of low-energy fracture of wrist, hip, and spine and the related risk factors in Chinese populations 50 years or older.
This study was a part of the Chinese National Fracture Survey (CNFS) carried out in 8 Chinese provinces in 2015. Data on 154,099 Chinese men and women 50 years or older were extracted from the CNFS database for calculations and analyses. Low-energy fracture was defined as fracture caused by slip, trip, or falls from standing height.
A total of 247 patients sustained low-energy fractures in 2014, indicating the incidence rate was 160.3/100,000 person-years, with 120.0 [95% confidence interval (CI), 95.5–144.5] and 213.1(95% CI, 180.7–245.6)/100,000 person-years in men and women, respectively. In men, advanced age, alcohol consumption, residence at second floor or above without elevator, sleep duration <7 h/day, and history of past fracture were identified to be significant risk factors for low-energy fractures. In women, advanced age, living in east region, higher latitude zone (40°N –49.9°N), alcohol consumption, more births, sleep duration <7 h/day, and history of past fracture were identified as significant risk factors. Supplementation of calcium or vitamin D or both was identified to be associated with reduced risk of fracture in women (odds ratio, 0.38; 95% CI, 0.20–0.75), but not in men.
These epidemiologic data on low-energy fractures provided updated clinical evidence base for national healthcare planning and preventive efforts in China. Corresponding interventions such as decreasing alcohol consumption and sleep improvement should clearly be implemented. For women, especially those with more births and past history of fracture, routine screening of osteoporosis, and intensive nourishment since menopause should be advocated.
Ultrasound-guided percutaneous injection of Pseudomonas aeruginosa-mannose sensitive hemagglutinin for treatment of chyle fistula following neck dissection
Authors: Chen Qiang , Chen Yanling , Su Anping , Ma Yu , Yu Boyang , Zou Xiuhe , Peng Dongmei , Zhu Jingqiang 
Published: January 2020

Abstract

Rationale:
Chyle fistula is a rare but troublesome complication of neck dissection. Topical application of Pseudomonas aeruginosa-mannose sensitive hemagglutinin (PA-MSHA) injection has been reported as a novel, viable, and effective approach in the treatment of chyle fistula following neck dissection. However, there have been no reports regarding the treatment of chyle fistula using ultrasound (US)-guided percutaneous injection of PA-MSHA.

Patient concerns:
We describe 2 patients with thyroid cancer who developed chyle fistula following neck dissection, which remained unresolved despite the use of conservative treatment.

Diagnoses:
Both the patients were diagnosed with chyle fistula by laboratory testing, which showed that drainage fluid triglyceride concentration was >100 mg/dL.

Interventions:
When conservative treatment failed, a 2 mL undiluted PA-MSHA preparation was percutaneously injected at the effusion site of the left supraclavicular area under US guidance with aseptic technique. Concomitantly, the drainage tube was clamped for at least 30 minutes.

Outcomes:
Chyle fistula in both patients were successfully resolved with this technique within 2 or 4 days, without notable side effects.

Lessons:
US-guided percutaneous injection of PA-MSHA is a simple and effective method to treat chyle fistula following neck dissection, which may serve as a useful addition to the medical treatment for cervical chyle fistula.
Association between interleukin-10 -1082A/G polymorphism and risk of ischemic stroke
Authors: Zuo Shuang , Zheng Tingting , Li Haishan 
Published: January 2020

Abstract
The Interleukin-10 -1082A/G polymorphism has been indicated to be correlated with ischemic stroke susceptibility, but the results of studies are still debatable. Thus, a meta-analysis was carried out.
Databases including PubMed, Embase, and CNKI were searched. Data were extracted and odds ratios (OR) with 95% confidence intervals (CI) were calculated.
12 case-control studies with 2722 cases and 2405 controls were included in this meta-analysis. IL-10 -1082A/G polymorphism may decrease the risk of ischemic stroke (G vs A: OR = 0.72, 95% CI: 0.59–0.87; GG vs AA: OR = 0.59, 95% CI:0.48–0.74; AG vs AA: OR = 0.69, 95% CI: 0.51–0.93; GG+AG vs AA: OR = 0.65, 95% CI: 0.50–0.84; GG vs AG+AA: OR = 0.71, 95% CI: 0.55–0.93). Meanwhile, similar results were also observed in matched studies, hospital-based subgroup, Asians, and large sample-size studies.
In conclusion, this meta-analysis suggested that the IL-10 -1082A/G polymorphism contributes to decreased ischemic stroke risk. Further large-scale and well-designed studies are still needed to confirm the results of our meta-analysis.
Busting the myth of extended blastocyst culture until Day 7
Authors: Alteri Alessandra , Corti Laura , Cermisoni Greta Chiara , Papaleo Enrico , Viganò Paola , Noventa Marco 
Published: January 2020

Abstract

Background:
The prolonged culture of embryos to the blastocyst stage represents an increasing procedure in Assisted Reproductive Technology (ART) laboratories. Generally, only blastocysts developing on Day 5 and Day 6 are considered suitable embryos for transfer, cryopreservation or biopsy while embryos developed at a slower rate after Day 6 are routinely discarded. However, also blastocysts developing on Day 7 can be viable and result in a healthy live birth. Unfortunately, data regarding the clinical outcomes of Day 7 blastocysts compared to blastocysts developing on Day 5 or Day 6 are controversial. In this systematic review and aggregate data meta-analysis, we aim to evaluate the real reproductive potential of delayed blastocysts on Day 7 in frozen cycles.

Methods:
We will include all studies, with no restriction regarding the study design (randomized and observational trials, including cohort and case-control), investigating the clinical success of blastocysts developed on Day 7 compared to Day 5 and Day 6 blastocysts. The primary outcomes are the clinical pregnancy rate (CPR) and ongoing pregnancy rate (OPR) following frozen-thawed embryo transfer (Day 7 vs Day 6, and Day 5); secondary outcomes are: live birth rate (LBR) following frozen-thawed embryo transfer, euploid rate and survival rate of thawed blastocyst. Two reviewers independently will judge the methodological quality of studies included in the meta-analysis using the criteria reported in the Cochrane Handbook for Systematic Reviews of Interventions or the Newcastle-Ottawa Scale according to the design of the trials. The meta-analysis will be performed using random effects models and heterogeneity will be assessed using Higgins I2 value. Summary estimate of the proportion of each outcome will be expressed as pooled proportion with 95% confidence interval (CI). The effect of the day on each outcome will be evaluated using a multilevel mixed-effects model with a moderator (the day). The effect will be expressed as odds ratio (OR) with 95% confidence interval (CI). A P value less than .05 will be considered statistically significant.

Ethics and dissemination:
This is a systematic review not requiring an ethical approval. Findings derived from this systematic review and meta-analysis will be published in a peer-reviewed journal.
A randomized controlled trial study protocol for Xiao-Qing-Long decoction in the treatment of refractory asthma
Authors: Yang Hongjing , Zhang Chuantao , Gan Wenfan , Chen Jun , Wu Jianying , Xiao Wei , Yang Yang , Zhao Keni , Sun Zengtao , Xie Xiaohong , Huang Qingsong 
Published: January 2020

Abstract

Introduction:
People with refractory asthma (RA) often seek help from Chinese medicine due to dissatisfaction with conventional treatments. External cold and internal fluid syndrome is the most common type of asthma and the Chinese herbal medicine formula Xiao-Qing-Long (XQL) decoction is commonly prescribed for patients with asthma with this syndrome. However, there is no direct evidence to support the efficacy and safety of XQL decoction for RA treatment and its potential mechanism is still unclear.

Methods:
We propose a double-blind, placebo-controlled, randomized superiority trial. After a 2-week run-in period, 112 eligible participants will be recruited and randomly allocated to an experimental group or control group in a 1:1 ratio. Patients in the experimental group will take XQL decoction, while patients in the control group will receive a matched placebo. Symbicort Turbuhaler and Montelukast sodium tablets will be provided as the basic treatment for the 2 groups. All participants will receive 4 weeks of treatment and 12 weeks of follow-up. The primary outcome is the mean change in the asthma control test score from the baseline to 4 weeks posttreatment. The secondary outcomes include quality of life, lung function, curative effect of traditional Chinese medicine, and rescue medication used. This trial will also include analyses of the associations between intestinal microbiota and RA treatment. Any side effects of the treatment will be recorded.

Discussion:
The results of this trial will provide consolidated evidence of the effect of XQL decoction for RA and the potential mechanism by which XQL decoction acts, which will inform treatment options for patients with RA.
A meta-analysis evaluating the relationship between B-type Raf kinase mutation and cervical lymphatic metastasis in papillary thyroid cancer
Authors: Ma Hongzhi , Wang Ru , Fang Jugao , Zhong Qi , Chen Xiao , Hou Lizhen , Feng Ling , Chen Xiaohong , Huang Zhigang , Zhao Huanhu 
Published: January 2020

AbstractBackground:B-type Raf kinase (BRAF) mutation is proved to be a critical predictive factor in papillary thyroid cancer (PTC) with aggressive characteristics. However, the association between BRAF mutation and cervical lymphatic metastasis in PTC is controversial.Methods:We searched papers on the study of BRAF mutation and cervical lymphatic metastasis in PTC patients through PubMed, Web of Science, Embase, and Cochranelibrary. The BRAF (+) cases, BRAF (–) cases, and cervical lymphphatic metastatic cases in both BRAF (+) and BRAF (–) groups were collected. After Quality assessment, statistical Analysis (funnel plot and Harbord evaluation, Random-effect model, heterogeneity, subgroup analysis, sensitivity analysis, and metacum analysis) were done by the Review Manager (RevMan) 5.3 and stata14 statistical software.Results:There were 78 cross-section studies which met our inclusion criteria. And all of them had no selection bias, publication bias, or any other bias. A significant association existed between BRAF mutation and cervical lymph node metastasis (LNM) (odds ratio [OR] = 1.63; 95% confidence interval [CI]: 1.44–1.84;P < .05). Overall, 46 studies were conducted among East Asians. Twenty four articles had provided the data of central lymph node metastasis (CLNM), 11 articles with the data of lateral lymph node metastasis (LLNM), and classic/conventional PTC (CPTC) was analyzed in 10 studies. Subgroup analyses were performed based on ethnicity, metastatic site, and subtype of PTC. Significant association between BRAF (+) mutation and cervical LNM were indicated in East Asians (OR = 1.73; 95% CI: 1.49–2.02;P < .05), in non-East Asians (OR = 1.57; 95% CI: 1.26–1.96;P < .05), and in CLNM (OR = 1.80; 95% CI: 1.56–2.07;P < .05). While no significant association was found in LLNM (OR = 1.37; 95% CI: 0.76–2.48;P = .29 > .05) and in CPTC (OR = 1.32; 95% CI: 0.97–1.80;P = .08 > .05). We did not find any other major changes when sensitivity analysis was performed. The metacum analysis showed no significant association existed before 2012. While a significant association began to exist between BRAF mutation and LNM from 2012, and this association became stable from 2017.Conclusions:We consider that a significant association exists between BRAF mutation and cervical LNM. Further meta-analysis on subgroup may reveal some valuable factors between BRAF gene mutation and LNM. And we do not recommend that BRAF (+) as the biomarker for LNM in PTC.