bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validierung des Düsseldorfer Screeningtools: ein traitbasierter Ansatz zur Erfassung der psychischen Belastung von Krebspatienten
Authors: Sisolefsky Franziska , Rana Madiha , Rana Majeed , Herzberg Philipp Y. 
Published: December 2020

Zusammenfassung
Hintergrund
Screening von psychischen Belastungen während einer Krebserkrankung ist notwendig, um gezielt die Patienten herauszufiltern, die psychologische Unterstützung benötigen. Derzeit geschieht dies überwiegend über die Abfrage akuter Probleme. Stabile interne und externe Risikofaktoren und präventiv wirkende Merkmale bleiben weitestgehend unberücksichtigt. Das neu entwickelte Düsseldorfer Screeningtool (DST) erfasst psychische Belastung mithilfe stabiler Traits, unter Berücksichtigung der sozialen Unterstützung und des Krankheitsverarbeitungsstils. Zielsetzung ist eine Validierung des DST anhand des Distress-Thermometers (DT) sowie der Psychoonkologischen Basisdokumentation (PO-Bado).

Methodik
Untersucht wurden 126 Patienten mit Plattenepithelkarzinomen im Bereich Hals und Kopf. Zur Festlegung des Cut-Off-Wertes wurden ROC Kurven (Receiver-Operating-Characteristics) berechnet. Als Maß für die Güte werden Area under Curve Werte (AUC) angegeben. Sensitivität und Spezifität wurden für den jeweils als Goldstandard genutzten Fragebogen festgelegt.

Ergebnisse
Die Diskriminationsfähigkeit des DST ist sowohl im Vergleich mit dem DT als auch mit der PO-Bado mit AUC-Werten von 0,62 bis 0,80 als gut zu bewerten. Bei einem Cut-Off-Wert des DT von 5 kann eine Sensitivität von 84,2 % bei gleichzeitiger Spezifität von 37,0 % angegeben werden. Im Vergleich zur PO-Bado kann ein Sensitivitätswert von 92,9 % bei gleichzeitiger Spezifität von 43,6 % angegeben werden.

Schlussfolgerung
Die Ergebnisse zeigen, dass auch ein traitbasierter Ansatz zur Erfassung von psychischer Belastung zielführend und sicher die Belastungssituation von Krebspatienten aufzeigen kann, sodass sich hier ein neuer Ansatz des Screenings in der Psychoonkologie herauskristallisiert hat.
Prognostic implications of dual tracer PET/CT: PSMA ligand and [18F]FDG PET/CT in patients undergoing [177Lu]PSMA radioligand therapy
Authors: Michalski Kerstin , Ruf Juri , Goetz Christian , Seitz Anna Katharina , Buck Andreas K. , Lapa Constantin , Hartrampf Philipp E. 
Published: December 2020

Abstract
Background
Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) with 177Lu-labeled PSMA ligands has achieved remarkable results in advanced disease stages of metastatic castration-resistant prostate cancer (mCRPC). However, not all patients benefit from this therapy. Different treatment responses could be explained by tumor heterogeneity triggered by progression and the number of prior treatments. PSMA-negative lesions can be missed on PSMA ligand PET/CT, which subsequently results in an underestimation of tumor burden. Conversely, high FDG uptake may also be an indicator of tumor aggressiveness and thus a poor prognostic marker for response to RLT and overall survival (OS). The aim of this analysis was to investigate the prognostic value of combined PSMA ligand PET/CT and [18F]fluorodeoxyglucose (FDG) PET/CT for outcome prediction in patients undergoing RLT.

Materials and methods
This bicentric analysis included 54 patients with mCRPC who underwent both FDG and PSMA ligand PET/CT imaging before RLT. In all patients, the pattern of PSMA ligand and FDG uptake was visually assessed. Patients with at least one FDG-positive, but PSMA-negative (FDG+/PSMA−) lesions were compared to patients without any FDG+/PSMA− lesions. A log-rank analysis was used to assess the difference in OS between subgroups.

Results
Median OS was 11 ± 1.8 months (95% CI 7.4–14.6). A significantly lower OS (p < 0.001) was found in patients with at least one FDG+/PSMA− lesion at baseline PET/CTs (n = 18) with a median OS of 6.0 ± 0.5 months (95% CI: 5.0–7.0 months). In comparison, patients without any FDG+/PSMA− lesions (n = 36) had a median OS of 16.0 ± 2.5 months (95% CI: 11.2–20.8 months).

Conclusion
FDG+/PSMA− lesions are a negative predictor of overall survival in patients with mCRPC undergoing RLT. However, it remains to be determined if patients with FDG+/PSMA− lesions should be excluded from PSMA RLT.
Dimensionality Reduction of Complex Metastable Systems via Kernel Embeddings of Transition Manifolds
Authors: Bittracher Andreas , Klus Stefan , Hamzi Boumediene , Koltai Péter , Schütte Christof 
Published: December 2020

AbstractWe present a novel kernel-based machine learning algorithm for identifying the low-dimensional geometry of the effective dynamics of high-dimensional multiscale stochastic systems. Recently, the authors developed a mathematical framework for the computation of optimal reaction coordinates of such systems that is based on learning a parameterization of a low-dimensional transition manifold in a certain function space. In this article, we enhance this approach by embedding and learning this transition manifold in a reproducing kernel Hilbert space, exploiting the favorable properties of kernel embeddings. Under mild assumptions on the kernel, the manifold structure is shown to be preserved under the embedding, and distortion bounds can be derived. This leads to a more robust and more efficient algorithm compared to the previous parameterization approaches.
Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Acute Coronary Syndrome: Implications for Platelet Reactivity?
Authors: Tscharre Maximilian , Wadowski Patricia P. , Weikert Constantin , Pultar Joseph , Eichelberger Beate , Panzer Simon , Gremmel Thomas 
Published: December 2020

Abstract
Background
In patients with acute coronary syndrome (ACS), angiotensin-converting enzyme (ACE) inhibitors are preferred over angiotensin receptor blockers (ARBs). However, in a recent pilot study, treatment with ACE inhibitors was associated with increased platelet reactivity compared to ARBs. Therefore, we sought to investigate the impact of renin-angiotensin-aldosterone system (RAAS) blockade with ACE inhibitors and ARBs on platelet aggregation in patients with ACS undergoing percutaneous coronary intervention.

Methods
On-treatment residual platelet reactivity in response to arachidonic acid (AA), adenosine diphosphate (ADP), SFLLRN, AYPGKF, and collagen was assessed by multiple electrode aggregometry (MEA) in 197 ACS patients on dual antiplatelet therapy (DAPT) with aspirin and either prasugrel or ticagrelor.

Results
One hundred sixty-five (83.7%) patients were treated with ACE inhibitors, 32 (16.3%) with ARBs. On-treatment residual AA- and ADP-inducible platelet reactivity was significantly higher in patients with ACE inhibitors (both p < 0.05). Likewise, SFLLRN was significantly higher in patients with ACE inhibitors (p = 0.036) and there was a trend for higher AYPGKF- and collagen-inducible platelet reactivity (p = 0.053 and p = 0.082). The incidence of high on-treatment residual platelet reactivity AA was significantly higher in patients with ACE inhibitors (52 [31.5%] vs. 3 [9.4%] patients; p = 0.019).

Conclusion
ACE inhibitors are associated with increased on-treatment residual platelet reactivity in ACS patients with potent DAPT. Further clinical trials are needed to elucidate the role of RAAS blockade with ACE inhibitors and ARBs in ACS patients treated according to current standards.
Be Prepared! How Pre-lab Modules Affect Students’ Understanding of Gene Mapping
Authors: Haagsman Marjolein E. , Koster Margot C. , Boonstra Johannes , Scager Karin 
Published: December 2020

AbstractLab activities are characteristic of life science education. In the current study, we investigate whether pre-lab modules can improve students’ understanding of the theories and experimental procedures associated with lab activities. Such effects were studied in context of an expository lab on gene mapping in biology undergraduate education. An experimental group of 126 students had access to an online pre-lab module to prepare for the lab activity; a control group of 90 students did not have access to this pre-lab module. The data revealed that students who studied the pre-lab module had a better understanding of the gene mapping theory, at the onset of the class, when compared with the control group. Additionally, these students appeared to ask fewer questions on what needed to be done in the lab, suggesting more awareness of the experimental procedure. Further, students who studied the online pre-lab module showed greater understanding of the theory in their lab reports. These findings suggest that students’ understanding of background theory and its relation to practice can readily be improved by enriching existing expository labs with pre-lab modules that contain information and questions on the complex conceptual information relevant to the lab experiment.
Focused Extracorporeal Shockwave Therapy in Physical Medicine and Rehabilitation
Authors: Crevenna Richard , Mickel Michael , Schuhfried Othmar , Gesslbauer Christina , Zdravkovic Andrej , Keilani Mohammad 
Published: December 2020

Abstract
Purpose of Review
Focused extracorporeal shockwave therapy (fESWT) is a physical treatment modality developed over the last 25 years for musculoskeletal indications. It has many indications in the field of physical medicine and rehabilitation (PM&R) and is effective, time-efficient, and cost-efficient. This review focuses on basics and on clinical indications as well as on significant trends in fESWT.

Recent Findings
In PM&R, stimulation of healing processes in tendons, surrounding tissue, and bones via mechanotransduction seems to be a relevant biological effect. The International Society for Medical Shockwave Treatment (ISMST) describes different types of indications (such as approved standard indications—in accordance with most scientific evidence—like calcifying tendinopathy of the shoulder, plantar fasciitis lateral epicondylopathy of the elbow, greater trochanter pain syndrome, patellar tendinopathy, Achilles tendinopathy and bone non-union, common empirically tested clinical uses, exceptional or expert indications, and experimental indications).

Summary
fESWT is a relevant treatment option in PM&R and regenerative medicine. In recent years, historical paradigms (for example, application in cancer patients) have changed and new indications (such as nerve regeneration, myofascial trapezius syndrome, low back pain, dermatosclerosis, and lymphedema) are supported. Future translational research should focus on establishing actual exceptional indications and experimental indications for clinical routine.
Predicting Operative Outcomes in Patients with Liver Disease: Albumin-Bilirubin Score vs Model for End-Stage Liver Disease-Sodium Score
Authors: Taylor George A. , Fagenson Alexander M. , Kuo Lindsay E. , Pitt Henry A. , Lau Kwan N. 
Published: December 2020

BACKGROUND:
The albumin-bilirubin score (ALBI) has recently been shown to have increased accuracy in predicting post-hepatectomy liver failure and mortality compared with the Model for End-Stage Liver Disease (MELD). However, the use of ALBI as a predictor of postoperative mortality for other surgical procedures has not been analyzed. The aim of this study was to measure the predictive power of ALBI compared with MELD-sodium (MELD-Na) across a wide range of surgical procedures.

STUDY DESIGN:
Patients undergoing cardiac, pulmonary, esophageal, gastric, gallbladder, pancreatic, splenic, appendix, colorectal, adrenal, renal, hernia, and aortic operations were identified in the 2015-2018 American College of Surgeons NSQIP database. Patients with missing laboratory data were excluded. Univariable analysis and receiver operator characteristic curves were performed for 30-day mortality and morbidity. Areas under the curves were calculated to validate and compare the predictive abilities of ALBI and MELD-Na.

RESULTS:
Of 258,658 patients, the distribution of ALBI grades 1, 2, 3 were 51%, 42%, and 7%, respectively. Median MELD-Na was 7.50 (interquartile range 6.43 to 9.43). Overall 30-day mortality rate was 2.7% and overall morbidity was 28.6%. Increasing ALBI grade was significantly associated with mortality (ALBI grade 2: odds ratio [OR] 5.24; p < 0.001; ALBI grade 3: OR 25.6; p < 0.001) and morbidity (ALBI grade 2: OR 2.15; p < 0.001; ALBI grade 3: OR 6.12; p < 0.001). On receiver operator characteristic analysis, ALBI outperformed MELD-Na with increased accuracy in several operations.

CONCLUSIONS:
ALBI score predicts mortality and morbidity across a wide spectrum of surgical procedures. When compared with MELD-Na, ALBI more accurately predicts outcomes in patients undergoing pulmonary, elective colorectal, and adrenal operations.
Novel Interdisciplinary Approach to GERD: Concomitant Laparoscopic Hiatal Hernia Repair with Transoral Incisionless Fundoplication
Authors: Choi Alyssa Y. , Roccato Mary Kathryn , Samarasena Jason B. , Kolb Jennifer M. , Lee David P. , Lee Robert H. , Daly Shaun , Hinojosa Marcelo W. , Smith Brian R. , Nguyen Ninh T. , Chang Kenneth J. 
Published: December 2020

BACKGROUND:
Transoral incisionless fundoplication (TIF) is an endoscopic alternative for the treatment of GERD. However, TIF does not address the hiatal hernia (HH). We present a novel approach with a laparoscopic HH repair followed by same-session TIF, coined concomitant transoral incisionless fundoplication (cTIF). The aim of this study was to assess the efficacy, safety, and feasibility of cTIF in a collaborative approach between Gastroenterology and surgery.

STUDY DESIGN:
Patients with confirmed GERD and >2 cm HH who underwent cTIF between 2018 and 2020 were included. Symptoms were assessed using the Reflux Disease Questionnaire, GERD Health-Related Quality of Life Index, and the Reflux Symptom Index pre and post cTIF. One-way ANOVA and paired samples t-test were used for statistical analysis.

RESULTS:
Sixty patients underwent cTIF (53% were men, mean age was 59.3 years) with 100% technical success. Mean ± SD HH measurement on endoscopy was 2.9 ± 1.5 cm. Scores on Reflux Disease Questionnaire for symptom frequency and symptom severity improved significantly from before to 6 months after cTIF (17.4 to 4.72; p < 0.01 and 16.7 to 4.56; p < 0.05, respectively). According to the GERD Health-Related Quality of Life Index, significant decreases were seen post cTIF in heartburn (23.26 to 7.37; p < 0.01) and regurgitation (14.26 to 0; p = 0.05). Reflux Symptom Index similarly decreased after cTIF (17.7 to 8.1 post cTIF; p < 0.01). Mean DeMeester score decreased from 43.7 to 4.9 and acid exposure time decreased from 12.7% to 1.28% post cTIF (p = 0.06).

CONCLUSIONS:
We present a novel multidisciplinary approach to GERD using a combined endoscopic and surgical approach with close collaboration between Gastroenterology and surgery. Our results suggest that cTIF is safe and effective in reducing reflux symptoms in a large spectrum of GERD patients.
Impact of the COVID-19 Pandemic on Lung Cancer Screening Program and Subsequent Lung Cancer
Authors: Van Haren Robert M. , Delman Aaron M. , Turner Kevin M. , Waits Brandy , Hemingway Mona , Shah Shimul A. , Starnes Sandra L. 
Published: December 2020

BACKGROUND:
Low-dose CT (LDCT) screening reduces lung cancer mortality by at least 20%. The COVID-19 pandemic required an unprecedented shutdown in our institutional LDCT program. The purpose of this study was to examine the impact of COVID-19 on lung cancer screening and subsequent cancer diagnosis.

STUDY DESIGN:
We analyzed our prospective institutional LDCT screening database, which began in 2012. In all, 2,153 patients have participated. Monthly mean number of LDCTs were compared between baseline (January 2017 to February 2020) and COVID-19 periods (March 2020 to July 2020).

RESULTS:
LDCT was suspended on March 13, 2020 and 818 screening visits were cancelled. Phased reopening began on May 5, 2020 and full opening on June 1, 2020. Total monthly mean ± SD LDCTs (146 ± 31 vs 39 ± 40; p < 0.01) and new patient monthly LDCTs (56 ± 14 vs 15 ± 17; p < 0.01) were significantly decreased during the COVID-19 period. New patient monthly LDCTs have remained low despite resuming full operations. Three- and 6-month interval follow-up LDCTs were prioritized and were significantly increased compared with baseline (11 ± 4 vs 30 ± 4; p < 0.01). The “no-show” rate was significantly increased from baseline (15% vs 40%; p < 0.04). Most concerning, the percentage of patients with lung nodules suspicious for malignancy (Lung-RADS 4) were significantly increased after screenings resumed (8% vs 29%; p < 0.01).

CONCLUSIONS:
COVID-19 caused significant disruption in lung cancer screening, leading to a decrease in new patients screened and an increased proportion of nodules suspicious for malignancy once screening resumed. Using lung cancer and the LDCT screening program as a model, this early analysis showed the unrecognized consequences related to the pandemic for screening programs and cancer care.
A mediated model of the effect of organizational culture on the intentions to engage in change-supportive behaviors: insights from the theory of planned behavior
Authors: Ahmad Ahmad Bayiz , Butt Atif Saleem , Chen Dingxiang , Liu Bangcheng 
Published: December 2020

AbstractThis study positions perceived organizational culture's (OC) as an important internal contextual factor that influences employee reactions to change. Drawing on the theory of planned behavior (TPB) and organization theory research, we analyze the mechanisms through which employee perceptions of OC generate its effect on employee responses to organizational change. Data from a field study of 171 employees in Kurdistan Region of Iraq's public school teachers showed that employee perceptions of developmental culture were positively and directly related to their change-supportive intentions (CSIs) and, as suggested by the TPB, its effects are simultaneously mediated by change-related attitude (CRA), subjective norm and perceived behavioral control. However, our findings demonstrated that hierarchical culture was only indirectly related to employee CSIs; this relationship was mediated only by CRA and subjective norm. This study is important because it broadens the remit of OC's role as change agent and provides valuable insight into how OC influences employee responses to change efforts in public organizations.
Family planning communication through mass media and health workers for promoting maternal health care utilization in Nigeria
Authors: Yaya Sanni , Bishwajit Ghose 
Published: December 2020

AbstractStudies have demonstrated that health communication programmes, through community health workers or mass media, are a key strategy to promote awareness and uptake of essential maternal health services. This study investigated whether or not family planning communication through mass media and health workers has any association with maternal health care utilization uptake in Nigeria. Cross-sectional data were extracted from the 2003–13 Nigeria Demographic and Health Surveys. The study sample comprised 41,938 women aged 15–49 years who had a live birth during the 5 years preceding the survey. Outcome variables were adequacy of antenatal care visits and place of delivery. Receiving family planning messages from the radio, TV, newspapers, a family planning worker or during a health facility visit were considered as possible sources of exposure to family planning information. Radio (32.6%) was the most commonly reported source of family planning information, followed by TV (17.5%) and newspapers (6.1%). Less than one-tenth of respondents were visited by family planning workers (9.5%) and about one-third visited a health facility during the previous 12 months (30.3%). Those who reported receiving family planning information from the three types of mass media and who had contact with a family planning worker and/or health facility were more likely to have at least eight antenatal care contacts (odds ratio for TV use=1.172, 95% CI=1.058–1.297) and deliver at a health facility (odds ratio for TV use=1.544, 95% CI=1.350–1.766). These findings indicate that family planning communication through mass media and health workers could potentially improve the utilization of antenatal and health facility delivery services in Nigeria.
Surgical and functional outcomes of two types of transcutaneous bone conduction implants
Authors: Scotta G , Allam A , Dimitriadis P A , Wright K , Yardley M , Ray J 
Published: December 2020

AbstractObjectiveThis study aimed to evaluate surgical and functional outcomes, in a tertiary referral centre, of two different types of semi-implantable transcutaneous bone conduction devices.MethodThis study involved prospective data collection and review of patients implanted between November 2014 and December 2016. Glasgow Hearing Aid Inventory (Glasgow Hearing Aid Benefit Profile or Glasgow Hearing Aid Difference Profile) and Client Oriented Scale of Improvement were completed where appropriate. Surgical and audiological outcomes were recorded in the surgical notes.ResultsGlasgow Hearing Aid Difference Profile and Glasgow Hearing Aid Benefit Profile showed similar mean score in the active and the passive transcutaneous bone conduction devices. Client Oriented Scale of Improvement showed improvements in listening situations. Post-operative speech reception threshold showed better mean threshold in the active transcutaneous bone conduction devices group when compared with the passive transcutaneous bone conduction devices group. No device failures or surgical complications existed in either group, with the surgical time being less in the passive transcutaneous bone conduction devices group.ConclusionBoth devices are reliable semi-implantable transcutaneous bone conduction devices with excellent surgical and functional outcomes and patient satisfaction. Overall surgical time was much less in the passive transcutaneous bone conduction devices group with no necessity for pre-planning. This is much easier to remove with the possibility of conversion to other devices in the manufacturer’s portfolio and wide-ranging wireless accessories. Further studies are needed to assess the longer-term results in a bigger population.
Motion Adaptation Based on Learning the Manifold of Task and Dynamic Movement Primitive Parameters
Authors: Cohen Yosef , Bar-Shira Or , Berman Sigal 
Published: December 2020

SUMMARYDynamic movement primitives (DMP) are motion building blocks suitable for real-world tasks. We suggest a methodology for learning the manifold of task and DMP parameters, which facilitates runtime adaptation to changes in task requirements while ensuring predictable and robust performance. For efficient learning, the parameter space is analyzed using principal component analysis and locally linear embedding. Two manifold learning methods: kernel estimation and deep neural networks, are investigated for a ball throwing task in simulation and in a physical environment. Low runtime estimation errors are obtained for both learning methods, with an advantage to kernel estimation when data sets are small.