bluuebunny/crossref_metadata_2025_split huggingface dataset:
Creating and sustaining collaborative multi-institutional industry site visit programs: a toolkit
Authors: Collins Tammy R.L. , Hoff Kiri , Starback Molly , Brandt Patrick D. , Holmquist Christopher E. , Layton Rebekah L. 
Published: November 2020

Background: As more early career scientists enter into diverse career pathways, visiting local companies or organizations can support their exploration of these paths. As an efficient way to facilitate this, we developed a collaborative regional site visit program: the Enhancing Local Industry Transitions through Exploration (ELITE) Consortium. Consortium members arrange half-day visits to local industry sites, thus providing companies and trainees the opportunity to meet and identify potential professional and career opportunities. Three different training institutions worked cooperatively in the development and maintenance of the program. The ELITE Consortium was developed with eight phased steps; guidelines and operating procedures were created for each of these steps and are provided along with sample materials for institutions interested in building similar programs. Methods: Prior to fully developing the program, trainee interests were evaluated via questionnaire. During program implementation and thereafter, program directors tracked attendance and collected career outcome data from publicly available sources to identify first job positions after training. Regression analyses and chi-squared analyses were used to examine site visit matches and career outcome data. Results: Analyses suggest a positive impact of site visits on postdoctoral and graduate trainees’ career outcomes at companies or institutions that match a similar sector (e.g., for-profit) and type (e.g., biotech, pharmaceutical, contract research organization). Despite a small sample size, evidence suggests an especially positive impact on trainees who organize site visits to companies compared with those who simply participate. Conclusions: The ELITE Consortium was successful in helping trainees explore and identify a multitude of career paths. Trainees attained employment either directly or in related companies and institutions visited by ELITE participants. The joint, three-institution, flexible nature of the ELITE Consortium positively impacts the program’s sustainability and reach. The toolkit provided here will help other institutions to replicate and adapt the program with minimal effort.
A tool for assessing the climate change mitigation and health impacts of environmental policies: the Cities Rapid Assessment Framework for Transformation (CRAFT)
Authors: Symonds Phil , Milner James , Mohajeri Nahid , Aplin Juliette , Hale Joanna , J Lloyd Simon , Fremont Henry , Younkin Sam , Shrubsole Clive , Robertson Lawrie , Taylor Jonathon , Zimmermann Nici , Wilkinson Paul , Davies Mike 
Published: November 2020

Background: A growing number of cities, including Greater London, have set ambitious targets, including detailed policies and implementation plans, to reach global goals on sustainability, health, and climate change. Here we present a tool for a rapid assessment of the magnitude of impact of specific policy initiatives to reach these targets. The decision-support tool simultaneously quantifies the environmental and health impacts of specified selected policies. Methods: The ‘Cities Rapid Assessment Framework for Transformation (CRAFT)’ tool was applied to Greater London. CRAFT quantifies the effects of ten environmental policies on changes in (1) greenhouse gas (GHG) emissions, (2) exposures to environmental hazards, (3) travel-related physical activity, and (4) mortality (the number of attributable deaths avoided in one typical year). Publicly available data and epidemiological evidence were used to make rapid quantitative estimates of these effects based on proportional reductions in GHG emissions and environmental exposures from current baseline levels and to compute the mortality impacts. Results: The CRAFT tool estimates that, of roughly 50,000 annual deaths in Greater London, the modelled hazards (PM2.5 (from indoor and outdoor sources), outdoor NO2, indoor radon, cold, overheating) and low travel-related physical activity are responsible for approximately 10,000 premature environment-related deaths. Implementing the selected polices could reduce the annual mortality number by about 20% (~1,900 deaths) by 2050. The majority of these deaths (1,700) may be avoided through increased uptake in active travel. Thus, out of ten environmental policies, the ‘active travel’ policy provides the greatest health benefit. Also, implementing the ten policies results in a GHG reduction of around 90%. Conclusions: The CRAFT tool quantifies the effects of city policies on reducing GHG emissions, decreasing environmental health hazards, and improving public health. The tool has potential value for policy makers through providing quantitative estimates of health impacts to support and prioritise policy options.
A quantitative CT parameter for the assessment of pulmonary oedema in patients with acute respiratory distress syndrome
Authors: Leiser Patrick , Kirschning Thomas , Weiß Christel , Hagmann Michael , Schoettler Jochen , Centner Franz-Simon , Haubenreisser Holger , Riffel Philipp , Janssen Sonja , Henzler Claudia , Henzler Thomas , Schoenberg Stefan , Overhoff Daniel 
Published: November 2020

Objectives
The aim of this study was to establish quantitative CT (qCT) parameters for pathophysiological understanding and clinical use in patients with acute respiratory distress syndrome (ARDS). The most promising parameter is introduced.

Materials and methods
28 intubated patients with ARDS obtained a conventional CT scan in end-expiratory breathhold within the first 48 hours after admission to intensive care unit (ICU). Following manual segmentation, 137 volume- and lung weight-associated qCT parameters were correlated with 71 clinical parameters such as blood gases, applied ventilation pressures, pulse contour cardiac output measurements and established status and prognosis scores (SOFA, SAPS II).

Results
Of all examined qCT parameters, excess lung weight (ELW), i.e. the difference between a patient’s current lung weight and the virtual lung weight of a healthy person at the same height, displayed the most significant results.
ELW correlated significantly with the amount of inflated lung tissue [%] (p<0.0001; r = -0.66) and was closely associated with the amount of extravascular lung water (EVLW) (p<0.0001; r = 0.72). More substantially than the oxygenation index (PaO2/FiO2) or any other clinical parameter it correlated with the patients’ mean SOFA- (p<0.0001, r = 0.69) and SAPS II-Score (p = 0.0005, r = 0.62). Patients who did not survive intensive care treatment displayed higher values of ELW in the initial CT scans.

Conclusions
ELW could serve as a non-invasive method to quantify the amount of pulmonary oedema. It might serve as an early radiological marker of severity in patients with ARDS.
A lumbális gerinc lokális stabilizátorainak vizsgálata és kezelése nem specifikus derékfájdalom esetén
Authors: Kasza Blanka Bernadett , Domján, Dr. Andrea 
Published: November 2020

Bevezetés és célkitűzés: A nem specifikus derékfájdalom hátterében a gerinc lokális stabilizáló izomzatának – mint a Musculus transversus abdominis (TrA) és a multifidi (MF) – funkciózavara áll. Vizsgálatunkban felmértük a lokális stabilizátorok szelektív feszítési képességét és fejleszthetőségét derékfájdalommal küzdő betegek körében.
Módszerek: Tíz önkéntest vizsgáltunk (7 nő, 3 férfi, átlagéletkor: 25,1 ± 1év). A deréktáji panaszokat az Oswestry-kérdőívvel, Roland–Morris-indexszel, és Quebec Back Pain Disability kérdőívvel, illetve Visual Analóg Skálával mértük fel. A szelektív feszítés vizsgálata és tanítása során felületes EMG-vel és ultrahanggal kontrolláltuk a TrA és az MF működését. Vizsgáltuk a testtömegközéppont kitérését, amelyet NeuroCom Basic Balance Masterrel rögzítettünk, a tréningprogram előtt és után.
Eredmények: Alanyaink a derékfájdalomra vonatkozó kérdőív eredményei alapján a közepes károsodás kategóriájába tartoztak, a tréningprogramot megelőzően nem voltak képesek a TrA és az MF szelektív megfeszítésére. A kontrollált feszítés elsajátítása és gyakorlása után képesek voltak a lokális stabilizátorokat szelektíven megfeszíteni, a statikus egyensúlyi paramétereik javultak, fájdalmuk csökkent.
Következtetés: Kutatásunk eredményei alátámasztották, hogy a TrA és az MF szelektív feszítése egy jól elsajátítható módszer, továbbá, hogy a szelektív feszítésük tanítása és gyakorlása – a többi lokális stabilizáló izom funkciójának helyreállítása mellett – a nem specifikus derékfájdalmak terápiájának alapját képezi.
Az ápolási dokumentáció hatékony alkalmazásának aspektusai
Authors: Oláh Mónika 
Published: November 2020

Bevezetés
Az ápolási dokumentáció vezetése az egyik legfontosabb önálló ápolói kompetencia, hiszen a dokumentáció egy olyan információforrás, ami visszajelzést ad az ápolók munkájáról és annak minőségéről is. Egy strukturálisan és tartalmát tekintve jól összeállított ápolási dokumentáció illeszkedik a dokumentációt alkalmazó területek specifikumaihoz, ápolási gyakorlatához, ami nélkülözhetetlen a személyre szabott és biztonságos betegellátás megvalósulásához.
Célkitűzés
Jelen közlemény célja az ápolási dokumentáció hatékony alkalmazását befolyásoló tényezők ismertetése.
Módszer
Szakirodalmi áttekintés során ismertetésre kerülnek az ápolási dokumentációval kapcsolatos irányelvek és útmutatások, továbbá azon hibák, amelyek a dokumentáció vezetése során leggyakrabban előfordulnak.
Következtetés
Hazai vonatkozásban az ápolási dokumentáció kutatása -jelentősége ellenére- nem kap kellő prioritást. Az ápolóképzésben és az ápolási gyakorlatban végbemenő változások szükségessé teszik az ápolási dokumentáció korszerűsítését is.
Does Size Really Matter?
Authors: Coelho-Prabhu Nayantara , Kane Sunanda 
Published: November 2020

Abstract
Ileocolonoscopy remains the mainstay of objective disease assessment in Crohn's Disease, and various validated indices are used to grade severity of the disease. The most commonly used indices are the Simple Endoscopic Score for Crohn's Disease (including the size of ulcers) and the Crohn's Disease Endoscopic Index of Severity (including the depth of ulcers). These measurements are highly subjective, especially the depth of an ulcer, and are based solely on the discretion of the endoscopist coupled with the imaging capabilities of the colonoscope and adequacy of the bowel prep. Narula et al. undertook a post hoc analysis of baseline predictors of endoscopic remission (ER) at week 26 in a subset (172 of 508) of moderate-severe Crohn's disease patients participating in the SONIC trial. The authors found no significant differences in the odds of achieving ER when comparing overall or segmental severe inflammation (high Simple Endoscopic Score for Crohn's Disease [>16 overall or >3 per segment] or Crohn's Disease Endoscopic Index of Severity [>12 overall or >3 per segment] scores) with moderate inflammation. The number of affected segments involved also did not impact the likelihood of achieving week 26 ER. The authors then found a potentially synergistic effect with large and deep ulcers in the ileum and rectum. The optimal time to assess whether ulcers ultimately heal or not is unknown, but waiting longer than 26 weeks may negate any lead time bias regarding ulcer size. Therefore, similar to many areas of life, it is likely that size ultimately does not matter, but instead location, location, and location.
Grow Local Manufacturing along US/Mexico Border Region for an Integrated Supply Chain in the Post–COVID-19 Era
Authors: Li Jianzhi 
Published: November 2020

Abstract
The current coronavirus disease pandemic, plus the strong movement of manufacturing reshoring, provide a unique opportunity for many US regions to grow local manufacturers. This technical note attempts to review the current situation and trend in US manufacturing. We then discuss challenges and necessary steps, such as asset mapping, required to grow local suppliers. Suggestions are then made to support growing local suppliers along the US/Mexico border region.
Brave new world an update on COVID-19 pandemic – A review
Authors: Gadó K. , Domján Gy. , Nagy Z.Z. 
Published: November 2020

AbstractEpidemics and pandemics have happened throughout the history of mankind. Before the end of the 20th century, scientific progress successfully eradicated several of the pathogens. While no one has to be afraid of smallpox anymore, there are some new pathogens that have never caused human disease before. Coronaviruses are a family of enveloped RNA viruses. In the 21st century, three of them have caused serious pandemics, including severe acute respiratory syndrome in 2002 and Middle East Respiratory Syndrome in 2012. In 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the coronavirus disease-19 (COVID-19) pandemic, which has destroyed hundreds of thousands of lives and continues to rage.
The Society’s Perception of Maddoa’ Ceremony in Enrekang South Sulawesi
Authors: Musyarif M. , Shaleh Muh. , Ahdar A. , Nirwana N. 
Published: November 2020

Maddoa’ is a traditional ceremony for society after conducting harvest rice in Enrekang South Sulawesi. It is an expression of joy and gratitude towards God Almighty for the success of farming. It has many values in social, cultural and religious lives and provides benefits for people’s life. This research discusses the process of carrying the traditional ceremony and the perception of society toward Maddoa’ in Kaju Bulo Village, Enrekang Regency, South Sulawesi. This research employs qualitative method with anthropology, sociology, and the phenomenology of religious approach. Thus, the data collected through observation, interview, and documentation. The result showed that Maddoa’ is held in the month of Muharram every Friday. It is held with other ceremonies of Mappadendang, Mappasosso, and eating together on the last day. The Maddoa’ gives various perception from society in Kaju Bulo village, Enrekang Regency, South Sulawesi. The Maddoa’ contained many values that must be preserved by the next generation. The values were friendship, unity, cooperation, and solidarity.
The Effect of Muslim Religiosity and Innovation Capability on Firm Survival: A Study on Small Enterprises During the Covid-19 Pandemic
Authors: Utomo Humam Santosa 
Published: November 2020

<p>This research aimed to examine and analyze the effect of Muslim religiosity and innovation capability on firm survival. Also, this research investigated the moderation role of environmental uncertainty on the effect of Muslim religiosity and innovation capability on firm survival. The study was conducted during the covid-19 pandemic. The analysis unit of this research was the owners of processed food small enterprises fostered by the regional government of Bantul Regency, Yogyakarta. The number of respondents involved in this research was 120 Muslim entrepreneurs. Data were collected using closed questionnaires distributed online, than processed using SEM-WarpPLS. The results showed that the Muslim religiosity and innovation capability significantly affected firm survival. Environmental uncertainty significantly weakened the effect of innovation capability on firm survival. However, environmental uncertainty insignificantly weakened the effect of Muslim religiosity on firm survival. These research results indicate the importance of religious formation for small entrepreneurs in this crisis time. Innovation is also important in increasing the firm survival of small companies during the covid-19 pandemic. </p>
The Effect Digitalization Zakat Payment Against Potential of Zakat Acceptance in National Amil Zakat Agency
Authors: Utami Pertiwi , Suryanto Tulus , Nasor M. , Ghofur Ruslan Abdul 
Published: November 2020

<p>The purpose of this study was to determine the effect of digitalization zakat payments on the potential for zakat acceptance at the BAZNAS Jakarta center. The originality of this research lies in the digitalization analysis of zakat payments to increase the potential for receiving BAZNAS center based on sharia economic approaches, and digital technology theory. The research method used is associative quantitative using a simple linear regression analysis technique with a sample size of 170 respondents selected based on purposive sampling technique. From the results of data analysis using SPSS 19.0, an R-value of 74.8% was obtained, which means that the relationship between the digitalization of zakat payments and the potential for receiving zakat at the BAZNAS is strong. The findings show that the digitalization variable of zakat payment or zakat payment (X) influences the potential for zakat receipt (Y) of 55.9%, and the remaining 40.1% is influenced by other factors not considered. Based on the results of deepening between the theory and practice of digital zakat revealed that the challenges in efforts to increase the potential for digital zakat acceptance in Indonesia are internet access which is still weak and uneven in Indonesian territory, building an 'attachment' relationship between <em>mustahi</em><em>q</em><em>, muzzaki</em> and BAZNAS, and the application of principles of sharia in the management of zakat. Therefore, the research explains the strategies that can be done to answer the challenges of digital zakat.</p><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><span style="vertical-align: inherit;"><br /></span></span></span></span>
The Critical Role of Aromatic-Aromatic Drug-Polymer Interactions to Provide Nanomedicines Containing Chloroquine: A Simple Proposal to Provide High Encapsulation, High Stability, and Prolonged Drug Release
Authors: Villamizar-Sarmiento María Gabriela , Moreno-Villoslada Ignacio , Oyarzun-Ampuero Felipe 
Published: November 2020

Abstract
Background: Chloroquine (CQ) is a drug commonly used to treat malaria. CQ has also gained interest for the treatment of other chronic diseases such as arthritis, lupus, cancer, diabetes, atherosclerosis, and dermatomyositis, among others. Since CQ is hydrophilic and low molecular-weight, attractive interactions with polymers in aqueous medium are weaker than with water, so that low encapsulation together with uncontrolled and fast release is observed. Importantly, a long-term administration of CQ is suggested, thus the development of formulations with controlled and prolonged release is desirable. Results: Here we propose the use of aromatic interactions between the cationic CQ and the FDA approved polymer poly(sodium 4-styrenesulfonate) (PSS) for the formation and stabilization of nanoparticles (NPs). The strategy consists on the simple mixture of two aqueous solutions containing the oppositelly charged molecules. UV-vis and NMR spectroscopy evidence intimate aromatic-aromatic interactions between CQ and PSS. CQ/PSS molar ratios from 0.2 to 0.5 allow obtaining NPs with spherical shape, size in the range of 170-410 nm, zeta potential from -18 to -45 mV, and particles number in the range of 0.9 - 6.6 x 1010 NPs/mL. Selected NPs (CQ/PSS molar ratio 0.4) are stable to wide variations in ionic strength (0-200 mM), pH (2-10) and temperature (20-50 °C). In addition, CQ/polymer 0.4 was also tested but with the absence of the aromatic group in the polymer, and providing smaller (70 nm), lower-concentrated (6.1 x 109 NPs/mL), and unstable particles, confirming the key role of the aromatic group. Furthermore, CQ/PSS NPs are stable during months and can be converted to a reconstitutable powder. Importantly, the selected NPs (CQ/PSS 0.4) show full drug association efficiency (100 %), very high drug loading (49 %), very high yield (89 %), and evidencing a drug entrapment/release governed by kinetic associations (≈99 %). Finally, release studies evidence a controlled and prolonged delivery. Conclusions: Considering the potential uses of CQ for chronic diseases, and the simplicity and efficiency of our proposal, it could be considered as a valuable alternative to developed nanomedicines. In addition, this strategy could be used for other drugs and polymers showing similar characteristics to CQ and PSS.
A m6A-related lncRNA Signature as a Novel Prognostic Factor for Gastric Cancer
Authors: Wang Haixu , Meng Qingkai , Ma Bin 
Published: November 2020

Abstract
Background: N6-methyladenosine (m6A)isa common form of mRNA modification regulated by m6A RNA methylation regulators. However, studies have not explored the role of m6A-related lncRNA in gastric cancer (GC). This study aimed atexploring biological and prognostic roles of m6A-related lncRNA in GC. Methods: We identified 800 m6A-related lncRNAs through correlation analysis of 13 main m6A RNA methylation regulators and all lncRNAs expressed in GC. We further categorized patients into train group and testing group equally. Results: A total of 11 m6A-related lncRNA signature associated with prognosis of GC were identified through univariate cox regression analysis and LASSO analysis which was validated using the testing dataset and complete dataset, respectively. More deaths and shorter survival time were reported for patients in the high-risk group compared to low-risk group. lncRNA signature is an independent prognosis predictor as shown by cox regression analysis of the complete dataset. Moreover, genes involved in base excision repair were highly expressed in patients in the high-risk group as shown by gene set enrichment analysis (GSEA) result whereas ECM receptor interaction and focal adhesion pathway were enriched in low-risk group. A nomogram on independent factors showed clinical net benefit asan overall survival predictor of GC. In addition, we identified four subgroups of GC patients with significant differences in overall survival (OS).Subgroup C1 and C2 responded well to immunotherapy, compared to subgroup C3 and C4. Conclusions: m6A-related lncRNA signature and four molecular subgroups provide information on the underlying molecular mechanism of GC and provide for a basis for development ofpersonalized therapy.
A Novel Two-Level Rate Control Algorithm Based on Visual Attention for 360-Degree Video for Versatile Video Coding Standard
Authors: Roodaki Hoda 
Published: November 2020

Abstract
360-degree video is providing users with an interactive experience to explore the scenes freely. But, because only a small portion of the entire video, called viewport, is watched at every point in time, transmitting the entire video is bandwidth-consuming. Since, the perceptual quality of such video mainly depends on the quality of the viewport, more bandwidth should be assigned to these important parts of the scene. Hence, understanding how people observe and explore 360-degree content is essential. In this paper, we propose a new Two-level rate control algorithm which tries to allocate more bits for encoding the viewport parts of a 360-degree video. The head and eye movements of the observers is used to investigate the visual attention of people to detect the viewports. Then, a Coding Tree Unit (CTU) level rate assignment approach is proposed to assign a proper number of bits to each CTU of the viewport and non-viewport parts. It is assumed that higher motion complexity results in higher bitrates of the encoded video. So, we propose to assign the proper number of bits to each CTU according to its motion complexity. Another novel part of our proposed approach is proposing a new metric to parameterize the motion complexity of each CTU using the high-order motion models in Versatile Video Coding (VVC) standard. Experimental results show that our proposed rate control, on average, achieves 58.27% reduction in bitrate in the Bjøntegaard-Bitrate scales, compared to the standard VCC standard. Furthermore, the proposed scheme provides a significantly better subjective viewing quality compared to the-state-of-the-art methods.