bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep learning to predict elevated pulmonary artery pressure in patients with suspected pulmonary hypertension using standard chest X ray
Authors: Kusunose Kenya , Hirata Yukina , Tsuji Takumasa , Kotoku Jun’ichi , Sata Masataka 
Published: November 2020

AbstractAccurate diagnosis of pulmonary hypertension (PH) is crucial to ensure that patients receive timely treatment. We hypothesized that application of artificial intelligence (AI) to the chest X-ray (CXR) could identify elevated pulmonary artery pressure (PAP) and stratify the risk of heart failure hospitalization with PH. We retrospectively enrolled a total of 900 consecutive patients with suspected PH. We trained a convolutional neural network to identify patients with elevated PAP (> 20 mmHg) as the actual value of PAP. The endpoints in this study were admission or occurrence of heart failure with elevated PAP. In an independent evaluation set for detection of elevated PAP, the area under curve (AUC) by the AI algorithm was significantly higher than the AUC by measurements of CXR images and human observers (0.71 vs. 0.60 and vs. 0.63, all p < 0.05). In patients with AI predicted PH had 2-times the risk of heart failure with PH compared with those without AI predicted PH. This preliminary work suggests that applying AI to the CXR in high risk groups has limited performance when used alone in identifying elevated PAP. We believe that this report can serve as an impetus for a future large study.
The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases
Authors: Coleman James L. J. , Ngo Tony , Smythe Rhyll E. , Cleave Andrew J. , Jones Nicole M. , Graham Robert M. , Smith Nicola J. 
Published: November 2020

AbstractGPR37L1 is an orphan G protein-coupled receptor expressed exclusively in the brain and linked to seizures, neuroprotection and cardiovascular disease. Based upon the observation that fragments of the GPR37L1 N-terminus are found in human cerebrospinal fluid, we hypothesized that GPR37L1 was subject to post-translational modification. Heterologous expression of GPR37L1-eYFP in either HEK293 or U87 glioblastoma cells yielded two cell surface species of approximately equivalent abundance, the larger of which is N-glycosylated at Asn105. The smaller species is produced by matrix metalloprotease/ADAM-mediated proteolysis (shown by the use of pharmacological inhibitors) and has a molecular weight identical to that of a mutant lacking the entire N-terminus, Δ122 GPR37L1. Serial truncation of the N-terminus prevented GPR37L1 expression except when the entire N-terminus was removed, narrowing the predicted site of N-terminal proteolysis to residues 105–122. Using yeast expressing different G protein chimeras, we found that wild type GPR37L1, but not Δ122 GPR37L1, coupled constitutively to Gpa1/Gαs and Gpa1/Gα16 chimeras, in contrast to previous studies. We tested the peptides identified in cerebrospinal fluid as well as their putative newly-generated N-terminal ‘tethered’ counterparts in both wild type and Δ122 GPR37L1 Gpa1/Gαs strains but saw no effect, suggesting that GPR37L1 does not signal in a manner akin to the protease-activated receptor family. We also saw no evidence of receptor activation or regulation by the reported GPR37L1 ligand, prosaptide/TX14A. Finally, the proteolytically processed species predominated both in vivo and ex vivo in organotypic cerebellar slice preparations, suggesting that GPR37L1 is rapidly processed to a signaling-inactive form. Our data indicate that the function of GPR37L1 in vivo is tightly regulated by metalloprotease-dependent N-terminal cleavage.
Cerebellar molecular layer interneurons are dispensable for cued and contextual fear conditioning
Authors: Marshall-Phelps Katy L. H. , Riedel Gernot , Wulff Peer , Woloszynowska-Fraser Marta 
Published: November 2020

AbstractPurkinje cells are the only output cell of the cerebellar cortex. Their spatiotemporal activity is controlled by molecular layer interneurons (MLIs) through GABAA receptor-mediated inhibition. Recently, it has been reported that the cerebellar cortex is required for consolidation of conditioned fear responses during fear memory formation. Although the relevance of MLIs during fear memory formation is currently not known, it has been shown that synapses made between MLIs and Purkinje cells exhibit long term plasticity following fear conditioning. The present study examined the role of cerebellar MLIs in the formation of fear memory using a genetically-altered mouse line (PC-∆γ2) in which GABAA receptor-mediated signaling at MLI to Purkinje cell synapses was functionally removed. We found that neither acquisition nor recall of fear memories to tone and context were altered after removal of MLI-mediated inhibition.
Low-intensity ultrasound combined with allogenic adipose-derived mesenchymal stem cells (AdMSCs) in radiation-induced skin injury treatment
Authors: Hormozi Moghaddam Zeinab , Mokhtari-Dizaji Manijhe , Nilforoshzadeh Mohammad Ali , Bakhshandeh Mohsen , Ghaffari Khaligh Sahar 
Published: November 2020

AbstractMesenchymal stem cells are mechano-sensitive cells with the potential to restore the function of damaged tissues. Low-intensity ultrasound has been increasingly considered as a bioactive therapeutic apparatus. Optimizing transplantation conditions is a critical aim for radiation-induced skin tissue injury. Therefore, the therapeutic function of adipose-derived mesenchymal stem cells to ultrasound stimulus was examined based on the mechanical index (MI). Mesenchymal stem cells were isolated from the adipose tissues of mature guinea pigs. An ultrasound system (US) was constructed with a 40 kHz frequency. The radiation-induced skin injury model was produced on the abdominal skin of guinea pigs by 60 Gy of radiation. Then, they were divided to 7 groups (n = 42): control, sham, US (MI = 0.7), AdMSCs injection, US AdMSCs (AdMSCs, under US with MI = 0.2), AdMSCs + US (AdMSCs transplantation and US with MI = 0.7) and US AdMSCs + US (combining the last two groups). The homing of stem cells was verified with fluorescence imaging. The groups were followed with serial photography, ultrasound imaging, tensiometry, and histology. The thickness of the skin was analyzed. Functional changes in skin tissue were evaluated with Young’s modulus (kPa). One-way ANOVA tests were performed to analyze differences between treatment protocols (p < 0.05). The results of Kumar’s score showed that radiation injury was significantly lower in the treatment groups of US AdMSCs and US AdMSCs + US than other groups after 14 days (p < 0.05). There was a significant difference in skin thickness between treatment groups with control, sham, and US groups after 60 Gy radiation and were closer to the thickness of healthy skin. Young’s modulus in US AdMSCs + US, US AdMSCs, and AdMSCs + US groups demonstrated a significant difference with the other groups (p < 0.05). Young’s modulus in US AdMSCs + US and US AdMSCs treatment groups were closer to Young’s modulus of the healthy skin. The histological results confirmed the improvement of acute radiation damage in the combined treatment method, especially in US AdMSCs + US and US AdMSCs groups with increasing the epithelialization and formation of collagen. An ultrasonic treatment plan based on a mechanical index of the target medium could be used to enhance stem cell therapy.
Comparison between blue-on-yellow and white-on-white perimetry in patients with branch retinal vein occlusion
Authors: Azuma Kunihiro , Inoue Tatsuya , Fujino Ryosuke , Igarashi Nozomi , Asano Shotaro , Nomura Yoko , Hashimoto Yohei , Azuma Keiko , Asaoka Ryo , Kadonosono Kazuaki , Obata Ryo 
Published: November 2020

AbstractThis study aimed to compare blue-on-yellow (B/Y) perimetry with white-on-white (W/W) perimetry in eyes with branch retinal vein occlusion (BRVO). The following measurements were performed in 29 eyes of 29 patients with resolved BRVO: W/W and B/Y perimetries using 10-2 test grid, retinal volume (RV) using optical coherence tomography (OCT), and vessel densities (VD) of the superficial capillary layer (VDs) and deep capillary layer (VDd) using OCT angiography (OCTA). First, the difference in the retinal sensitivity (RS) between BRVO-affected and unaffected areas was compared between RS_B/Y and RS_W/W in the parafoveal and extrafoveal areas. Moreover, the structure–function relationship between vessel density and RS was compared between B/Y and W/W perimetries (RS_B/Y and RS_W/W, respectively). The difference in RS between BRVO-affected and unaffected areas was significantly larger with RS_B/Y than with RS_W/W in both the parafoveal and extrafoveal areas. In the parafoveal area, VDs, VDd, and RV were significantly correlated with both RS_W/W and RS_B/Y. In contrast, in the extrafoveal area, only VDd was included in the optimal models. Our findings suggest that RS_B/Y more strongly reflects the anatomical structure and BRVO-affected area.
Genomic selection for heterobothriosis resistance concurrent with body size in the tiger pufferfish, Takifugu rubripes
Authors: Lin Zijie , Hosoya Sho , Sato Mana , Mizuno Naoki , Kobayashi Yuki , Itou Takuya , Kikuchi Kiyoshi 
Published: November 2020

AbstractParasite resistance traits in aquaculture species often have moderate heritability, indicating the potential for genetic improvements by selective breeding. However, parasite resistance is often synonymous with an undesirable negative correlation with body size. In this study, we first tested the feasibility of genomic selection (GS) on resistance to heterobothriosis, caused by the monogenean parasiteHeterobothrium okamotoi, which leads to huge economic losses in aquaculture of the tiger pufferfishTakifugu rubripes.Then, using a simulation study, we tested the possibility of simultaneous improvement of parasite resistance, assessed by parasite counts on host fish (HC), and standard length (SL). Each trait showed moderate heritability (square-root transformed HC:h2 = 0.308 ± 0.123, S.E.; SL:h2 = 0.405 ± 0.131). The predictive abilities of genomic prediction among 12 models, including genomic Best Linear Unbiased Predictor (GBLUP), Bayesian regressions, and machine learning procedures, were also moderate for both transformed HC (0.248‒0.344) and SL (0.340‒0.481). These results confirmed the feasibility of GS for this trait. Although an undesirable genetic correlation was suggested between transformed HC and SL (rg = 0.228), the simulation study suggested the desired gains index can help achieve simultaneous genetic improvements in both traits.
The influence of networks of general trust on willingness to communicate in English for Japanese people
Authors: Ito Takehiko 
Published: November 2020

AbstractThis study investigates the effect of a network of general trust on the willingness to communicate in English among Japanese people. Previous studies have shown that general trust positively affects the willingness to communicate in English for Japanese people. However, the network structure of general trust and its effects have not yet been revealed. The present study conducted a network analysis with 761 Japanese university students and 601 Japanese social survey participants, for 1362 participants total. Four variables regarding general trust positively affected the willingness to communicate in English for all participants, whereas one variable had a negative effect if each network was estimated for only university students or social survey participants. Centrality indices, such as node strength, closeness, and expected influence, revealed the centrality of several variables in the network of all participants. Bootstrapping methods showed the trustworthiness of the estimated edges and centrality indices. Contrary to the regression analysis, the network analysis can help us understand the profound effect of general trust on the willingness to communicate in a second language, which will prove useful for intervention studies.
Methamphetamine induces cardiomyopathy by Sigmar1 inhibition-dependent impairment of mitochondrial dynamics and function
Authors: Abdullah Chowdhury S. , Aishwarya Richa , Alam Shafiul , Morshed Mahboob , Remex Naznin Sultana , Nitu Sadia , Kolluru Gopi K. , Traylor James , Miriyala Sumitra , Panchatcharam Manikandan , Hartman Brandon , King Judy , Bhuiyan Mohammad Alfrad Nobel , Chandran Sunitha , Woolard Matthew D. , Yu Xiuping , Goeders Nicholas E. , Dominic Paari , Arnold Connie L. , Stokes Karen , Kevil Christopher G. , Orr A. Wayne , Bhuiyan Md. Shenuarin 
Published: November 2020

AbstractMethamphetamine-associated cardiomyopathy is the leading cause of death linked with illicit drug use. Here we show that Sigmar1 is a therapeutic target for methamphetamine-associated cardiomyopathy and defined the molecular mechanisms using autopsy samples of human hearts, and a mouse model of “binge and crash” methamphetamine administration. Sigmar1 expression is significantly decreased in the hearts of human methamphetamine users and those of “binge and crash” methamphetamine-treated mice. The hearts of methamphetamine users also show signs of cardiomyopathy, including cellular injury, fibrosis, and enlargement of the heart. In addition, mice expose to “binge and crash” methamphetamine develop cardiac hypertrophy, fibrotic remodeling, and mitochondrial dysfunction leading to contractile dysfunction. Methamphetamine treatment inhibits Sigmar1, resulting in inactivation of the cAMP response element-binding protein (CREB), decreased expression of mitochondrial fission 1 protein (FIS1), and ultimately alteration of mitochondrial dynamics and function. Therefore, Sigmar1 is a viable therapeutic agent for protection against methamphetamine-associated cardiomyopathy.
Designed DNA nanostructure grafted with erlotinib for non-small-cell lung cancer therapy
Authors: Wang Yuqi , Cheng Jin , Zhao Di , Liu Yan , Luo Tao , Zhong Yi-Fang , Mo Fangli , Kong Xiang-Yang , Song Jie 
Published: November 2020

Schematic representation of designed DNA nanostructure grafted with erlotinib and enhanced inhibition of tumor growth for non-small-cell lung cancer (NSCLC).
Remote Microphone System Use in Preschool Children With Autism Spectrum Disorder and Language Disorder in the Classroom: A Pilot Efficacy Study
Authors: Keller Mary Alice , Tharpe Anne Marie , Bodfish James 
Published: November 2020

Purpose
The present pilot study aimed to provide estimates of the feasibility and efficacy of a remote microphone (RM) system as an augmentative intervention to improve the functional listening performance of preschool children with autism spectrum disorder (ASD) and language disorder.

Method
Eight children with ASD and language disorder participated. Efficacy of the RM system was determined by evaluating participants' functional listening performance, as measured by an observational measure in RM-off and RM-on conditions. Responses were evaluated at the individual level using an alternating conditions design.

Results
Adequate feasibility was demonstrated as all participants were able to complete tasks in the RM-on condition. A subset of participants showed significant improvements in their functional listening performance in the RM-on condition, as demonstrated by visual inspection and effect sizes (nonoverlapping data points and percentage of data points exceeding the mean), indicating that there may be important sources of individual differences in responses to RM use in children with ASD.

Conclusion
The results of this pilot study provide support for future research on RM systems to target functional listening performance in children with ASD and language disorder.
Wheat yield convergence and its driving factors in countries along the Belt and Road
Authors: Zhang Xiaoheng , Wang Zhina , Qing Ping , Koemle Dieter , Yu Xiaohua 
Published: November 2020

ABSTRACT
Improving the wheat yield of countries along the Belt and Road (BR) plays a core role in ensuring global food security. However, little attention has been paid to the wheat yield variation and the determinants across these countries. This paper analyzes wheat yield convergence in countries along the BR using the club-convergence test. The empirical results show that instead of one convergence for all countries along the BR, the wheat yields are converging into three clubs. Furthermore, we investigate the impact of climate change and agricultural production technology on wheat yield convergence, and find that countries along the BR with a one degree Celsius increase in temperature are 36.5% (32.7%) more likely to converge to the high-level yield club. This may be related to the lower frequency of frost and higher photosynthetic capacity of wheat. We also find that a one kilogram increase in fertilizer application per hectare will result in a 0.4% (0.5%) higher probability of countries along the BR converging to the high-level yield club. Countries along the BR should pay more attention to coordinating production technologies and climate change to ensure food security.
Recent Developments and Future Prospects of Manufacturing of Broad Gauge Railway Sleepers Using Waste Materials in India
Authors: Kumar Bagal Dilip , Kumar Singh Sangam , Naik Bibekananda , Barua Abhishek , Jeet Siddharth , Parida Biswajit , Kumar Pattanaik Ajit 
Published: November 2020

AbstractRailways form the backbone of all economies, transporting goods, and passengers alike. Sleepers play a pivotal role in track performance and safety in rail transport. Composite sleeper is becoming a suitable alternative for replacing the existing concrete, steel and particularly timber sleeper in both mainline and heavy haul rail network. Composite sleeper technologies are already available but they have gained limited acceptance by the railway industry. A number of composite railway sleeper technologies have been developed but their applications in rail tracks are still limited. This paper discusses in brief about the materials that have been used in making sleepers in the early stages of railways and rigorously reviews the recent developments on composite sleepers and identifies the critical barriers to their widespread acceptance and applications. It has been shown that majority of the sleepers do not last till their expected design life resulting in massive replacement and repair cost. Currently the composite sleeper technologies that are available ranges from sleepers made with recycle materials starting from plastic, rubber, construction waste etc. While these recycled material based sleepers are low cost, the major challenges of using this type of sleepers are their limited strength, stiffness and dynamic properties which in most cases, are incompatible with those of traditional concrete, steel or timber sleeper. This paper rigorously reviews the recent developments on composite sleepers and identifies the critical barriers to their widespread acceptance and applications.
Compressive Strength of Mortar with Alkali Activated Fly ash and Ground Granulated Blast Furnace Slag
Authors: Panda Sagarika , Panigrahi Ramakanta , Narasimham M.L. 
Published: November 2020

Abstract
The geopolymer concrete is a new technology that replace ordinary cement concrete with cement less concrete using the different industrial by-products considered as waste to the society. These materials create a hazardous environmental condition. To overcome the same, many researchers have reported replacement of these materials with cement in concrete work. These materials do not possess much binding properties. Hence, an alkaline solution is utilized to activate the same. In the present study, the compressive strength of the geopolymer mortar prepared with Class F fly ash and ground granulated blast furnace slag in different ratios are examined. It is observed that the compressive strength achieved from elevated temperature cured samples is higher than the ambient temperature cured sample. Increase in ground granulated blast furnace slag content also increases the compressive strength parameters of the geopolymer mortar sample.
Influence of Natural Fibers as Additive on Characteristics of Stone Mastic Asphalt
Authors: Parimita Pragnya 
Published: November 2020

Abstract
The purpose of this article is to emphasize on the development of stabilized Stone Mastic Asphalt Mix for laudable and tangible pavement performance. Attempts have been made to stabilize SMA Mix using synthetic fibers which is too costly and not readily available. The concept of using natural fibers and waste materials to replace these energy intensive synthetic fibers or polymer additives is a recent development in this field. India, being an agricultural economy, produces fairly huge quantity of natural fibers such as coconut, sisal, banana, sugar cane, jute etc. The addition of these natural fibers as additives to SMA has really thrust a revolutionary change to the transport system. This research is an attempt to propose an ideal surface course for the pavement of India using natural fibers stabilized SMA that can face rough weather conditions and more loads. Analyzing the illustrated results of the comparative study on the performance of the stabilized mixtures it is inferred that additive plays a prominent role in the volumetric, mechanical and drain down characteristics of SMA. Improved Marshall Quotient and Marshall Stability value show higher rutting resistance and improved tensile strength shows better Cracking Resistance. This study brings out the importance of additives in SMA and proposes an eco-friendly alternative to Synthetic fibers.
Provision of Percolation Pits for Embankment Safety: A-State-of-Art-and-Review
Authors: Subhadarsini Swarnima , Giri Debabrata , Sekhar Das Sudhanshu 
Published: November 2020

Abstract
An embankment is a vacillating wall of earth or concrete, which directs the river or flood water to its actual target and prevents farmlands. During heavy flood, water overtops the crest and silts clog sluice gate. This creates wave and extensive silt pressure on the wall. In order to avoid such situation, it needs to diverted floodwater through a water channel to a silt trap. Silts will settle in the silt trap and clean water will lend into the injection well passing through the multilayer of injection media. The floodwater is accommodated in a specially designed storage well accompanied with percolating cloak. The cleared water columns injected into the deeper layers of semi-impervious soil strata through the non-clogging percolating screens attached to the well. This diverts the water to percolates to deeper earth strata by capillary action and helps to recharge ground water. The paper aims on deliberating different eco-friendly design and construction technique of high raise embankment. Apart from this, an attempt has been made to showcase the increasing trends in research publication and activity in the area of eco-friendly construction practices to direct and absorb water without affecting the artesian spring.