bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal investment, body condition and calf growth in humpback whales
Authors: van Aswegen Martin , Szabo Andy , Currie Jens J. , Stack Stephanie H. , Evans Lewis , Straley Janice , Neilson Janet , Gabriele Christine , Cates Kelly , Steel Debbie , Bejder Lars 
Published: December 2024

AbstractGiven recent declines in North Pacific humpback whale (Megaptera novaeangliae) reproductive output and calf survival, there is additional urgency to better understand how mother–calf pairs allocate energy resources across their migratory cycle. Here, unoccupied aerial system (UAS; or drone) photogrammetry was used to quantify the body size and condition (BC) of humpback whales on their Hawaiʻi (HI) breeding and Southeast Alaska (SEAK) feeding grounds. Between 2018 and 2022, we collected 2410 measurements of 1659 individuals. Rates of change in body volume (BV) and length (BL) were quantified using 803 repeat measurements of 275 individuals. On average, HI mothers lost 0.106 m3 or 96.84 kg day−1 while fasting, equivalent to 2641 MJ day−1 or 830 kg of krill and 424 kg of Pacific herring daily. HI calf BV and BL increased by 0.035 m3 and 2.6 cm day−1, respectively. In SEAK, maternal BV increased by 0.015 m3 or 14.54 kg day−1 (367 MJ day−1), while calf BV and BL increased by 0.039 m3 and 0.93 cm day−1, respectively. Maternal investment in calf growth correlated with both female BL and BC, with larger females producing larger, faster‐growing calves. Finally, using 330 measurements from 156 females, we quantified differences in BC increase over four feeding seasons. Lactating females exhibited an average BC increase of 6.10%, half that of unclassified females (13.51%) and six times lower than pregnant females (37%). These findings represent novel insights into the life history of humpback whales across their migratory cycle, providing key baseline data for bioenergetic models elucidating the effects of anthropogenic disturbance and rapidly changing ocean ecosystems.
imageKey points
On average, Hawaiʻi (HI) mothers lost 0.106 m3 or 96.84 kg day−1, equivalent to 2641 MJ day−1. Over a 60 day period, this corresponded to an estimated mean energetic cost of 158 GJ, or ≈50 tons of krill or ≈25 tons of Pacific herring, surpassing the total energetic cost of gestation estimated for humpback whales of similar length.
In Southeast Alaska (SEAK), maternal body volume (BV) increased by just 0.015 m3 or 14.54 kg day−1 (367 MJ day−1). Further, SEAK lactating females showed the slowest rates of growth in body width and condition over a 150 day period compared to non‐lactating females.
Maternal investment in calf growth correlated with both maternal length and body condition, with larger females producing larger, faster‐growing calves. In HI, however, the ratio between maternal BV lost and calf BV gained (conversion efficiency) was relatively low compared to other mammals.
Systems-Based Approach to Predicting Thermal Barrier Coating Delamination Due to CMAS Infiltration
Authors: Teglas Matei , Bojdo Nicholas , Elms Jacob , Pawley Alison , Covey-Crump Stephen , Jones Merren 
Published: December 2024

Abstract
Calcium-magnesium alumino-silicate (CMAS) infiltration and attack are difficult to simulate at real-world rates. To better understand the sensitivity of the process to engine operating parameters and CMAS chemical composition, a systems-based reduced order infiltration model that incorporates combustion gas properties, TBC microstructural properties, thermal barrier coating (TBC) heat transfer properties, and CMAS physical properties was developed. The aim was to predict the time to delamination for aircraft engines operating in non-benign environments. The penetration depths reached by a synthetic four-element CMAS mixture within a clean TBC were calculated by finite difference method. Engine operating conditions and TBC top coat types were varied to study the effects on the penetration depths and times. A larger difference between operating temperature and cold shock temperature was found to increase the risk of Mode I delamination. An increase in engine operating temperature had little effect on the critical penetration depth, but significantly influenced the actual penetration depth and time. An increase in electron beam - physical vapor deposition (EB-PVD) TBC taper angle resulted in a decrease in the critical penetration depths, suggesting a greater risk of Mode I delamination. The time taken to reach the actual penetration depth increased with operating time, until the TBC was consumed, at which point penetration time decreased with operating temperature due to lower melt viscosity.
The Effect of PTFE Content on Tribological Properties of Polyoxymethylene Composites
Authors: Li Xinmin , Nie Laishi , Hung Wing San Tony , Wu Yonglong , Qiu Zhengjie 
Published: December 2024

Abstract
Polyoxymethylene (POM) and its composites with excellent mechanical properties are often used as alternative materials in gear transmission design. This paper considers the practical application scenario of POM gears, using a pin-on-disk tribometer to simulate the Hertzian contact and sliding part of gear mesh. The effects of polytetrafluoroethylene (PTFE) content (0%, 5%, 10%, and 15%), maximum contact pressure (40 MPa and 60 MPa), sliding speed (0.1 m/s and 0.5 m/s), and ambient temperature (room temperature and 70 °C) on the tribological properties of POM composites under self-mated contact are investigated. The results show that the tribological properties of the composites tend to improve with the increase of PTFE content under the two ambient temperature conditions, reaching the optimum at 15% PTFE content. However, the addition of PTFE does not improve the tribological properties of the composites under the most severe conditions of 70 °C and a pressure–velocity (PV) value of 30 MPa m/s. At two ambient temperatures, pure POM and its composites exhibit the lowest friction coefficient at a PV value of 6 MPa m/s and the smallest specific wear-rate at a PV value of 20 MPa m/s. The friction coefficient of composites decreases with an increase in ambient temperature from room temperature to 70 °C at a sliding speed of 0.1 m/s but increases at a sliding speed of 0.5 m/s. Analysis of variance (ANOVA) results indicate that all factors are significant, except for temperature which does not have a significant effect on the friction coefficient. Additionally, this paper analyzes the wear mechanisms of composites.
Multiple dimensions of neurological injury in a liver transplant recipient with cryptococcal meningitis
Authors: Shoham Shmuel , Thapaliya Sabin , Avery Robin , Baddley John , Dioverti Veronica , Durand Christine , Gurakar Ahmet , Karaba Andrew , Kates Olivia , Maragakis Nicholas , Permpalung Nitipong , Werbel William , Casadevall Arturo 
Published: December 2024

ABSTRACT

Background

Meningitis due to
Cryptococcus neoformans
continues to cause substantial morbidity and mortality in victims of this infection. Worldwide, immunosuppression due to uncontrolled HIV disease is the main risk factor. In the United States, however, a substantial percentage of cryptococcal meningitis cases occur in people with non-HIV immune compromising conditions such as solid organ transplantation. Neurological damage in cryptococcal meningitis can be caused by direct fungal-induced injury, as a consequence of elevated intracranial pressure, and by immune-mediated injury. An understanding of these pathophysiological processes and an appreciation for the roles of specific treatments to address them are necessary for optimal care of patients with cryptococcal meningitis.

Case Summary
In this report, we present a case of cryptococcal meningitis in a liver transplant recipient whose disease manifestations were due to (i) fungal invasion, (ii) elevated intracranial pressure, and (iii) an over-exuberant immune response that blossomed soon after reduction of immunosuppression and clearance of cerebrospinal fluid culture.

Conclusion
This patient’s course exemplifies the multidimensional nature of neurological injury in cryptococcal meningitis and the diverse treatment strategies required to address the infection and complications.

IMPORTANCE
An understanding of the pathophysiological processes that cause neurological damage in cryptococcal meningitis is critical for optimal management of patients with this infection. This case highlights three such processes so that they can be quickly diagnosed and treated before irreversible damage occurs.
Disseminated
Magnusiomyces clavatus
(
Geotrichum clavatum
) infection following allogenic stem cell transplantation: a case report
Authors: Alzahrani Rahmah S. , Vinh Donald C. , Rajda Ewa , Popradi Gizelle , Dufresne Philippe J. , Cheng Matthew P. 
Published: December 2024

ABSTRACT

Background

Magnusiomyces clavatus
(formerly
Geotrichum clavatum/Saprochaete clavata
) is a yeast with a filamentous form, as well as an uncommon, yet emerging opportunistic pathogen. It occurs primarily in patients experiencing prolonged neutropenia, and there is limited evidence available to guide antifungal agent selection and treatment decisions.

Case Summary

We present a case of disseminated infection caused by
M. clavatus
in a patient with myelofibrosis following allogeneic hematopoietic stem cell transplantation. The patient was treated with voriconazole, as well as liposomal amphotericin B, along with granulocyte transfusion. The patient died from persistent fungemia, refractory septic shock, and multiorgan failure 20 days after the infection was first diagnosed.

Conclusion
We subsequently discuss the epidemiological, clinical, and therapeutic features of this severe fungal infection and present a review of currently available literature.
Draft genome of halophilic
Salinicoccus roseus
H15 isolated from desert rock varnish in Ma'an, Jordan
Authors: Alnaimat Sulaiman M. , Abushattal Saqr , Dmour Saif M. 
Published: December 2024

ABSTRACT

Here, we report the draft genome sequence of
Salinicoccus roseus
H15, isolated from desert rock varnish in Ma'an, Jordan. The genome size is 2,457,773 bp with a GC content of 49.31 mol%. The genome includes 3,064 genes and 135 carbohydrate-active enzymes, demonstrating adaptations for survival in extreme environments.
Primary Esophageal Rhabdomyosarcoma: An Exceptionally Rare Cause of Pediatric Dysphagia
Authors: Ataollahi Maryam , Mashhadiagha Amirali , Karbasian Fereshteh , Moshfeghinia Reza , Arabpour Javad , Geramizadeh Bita 
Published: December 2024

Background: Esophageal embryonal rhabdomyosarcoma (ERMS), a rare pediatric cancer, mimicked achalasia in a case involving dysphagia and vomiting. Diagnosis and chemotherapy necessitate careful monitoring due to potential complications.Case presentation: A 12‐year‐old girl with no prior medical history presented with progressive dysphagia and vomiting. Initial diagnosis suggested achalasia, but further evaluation revealed a large mediastinal mass causing esophageal compression. Biopsies confirmed primary ERMS of the esophagus with metastases. Despite chemotherapy, she developed complications, including neutropenic enterocolitis and posterior reversible encephalopathy syndrome (PRES). Unfortunately, she succumbed to neutropenic sepsis.Conclusion: In this case study, we presented our experience regarding the clinical course of this disease, treatment strategy, and prognosis, in addition to the limited previous information in the literature.
Evaluation of microRNA‐10a and microRNA‐210 as Biomarkers in Sepsis Patients With Acute Kidney Injury
Authors: Susianti Hani , Sutrisnani Catur Suci , Santosa I.P. Adi , Febrianto Wahyu , Kusdjianto Amanda Yuanita , Kuwoyo Kevin Putro , Riyu Elita 
Published: December 2024

Background: Sepsis‐associated acute kidney injury (AKI) is a condition that increases in‐hospital mortality and the risk of progression to CKD. The current method of detecting AKI, which relies on increased serum creatinine levels or a decrease in urine output, has low sensitivity. Early diagnosis and appropriate intervention in AKI can lead to improved patient outcomes. Several low molecular weight proteins and microRNAs detected in AKI are considered early biomarkers of AKI, such as miR‐10a‐5p and miR‐210‐3p.Method: A cross‐sectional study was conducted among 62 participants, consisting of 26 sepsis patients with AKI, 26 sepsis patients without AKI, and 10 healthy controls. AKI was determined according to KDIGO criteria. MicroRNA expression was analyzed using reverse transcription quantitative polymerase chain reaction (RT‐qPCR). Statistical analysis was obtained using the Kruskal–Wallis test, Spearman’s correlation coefficient, and ROC curve analysis.Result: The median miR‐10a‐5p expression of the healthy controls versus sepsis with AKI versus sepsis without AKI groups was 10.38 (5.50–33.82) versus 10.32 (3.32–31.53) versus 9.76 (0.32–97.36), while the median miR‐210‐3p expression was 0.20 (0.03–0.41) versus 0.38 (0.04–1.24) versus 0.29 (0.06–1.67), respectively, with p = 0.721 for miR‐10a‐5p and p = 0.013 for miR‐210‐3 p. A significant increase in miR‐210‐3p expression was found in the sepsis with AKI compared to the healthy controls (p = 0.013) and sepsis without AKI (p = 0.034). miR‐210‐3p significantly correlated with creatinine and urea serum level (p < 0.05); miR‐10a‐5p did not have a significant correlation. The sensitivity and specificity of miR‐10a‐5p were 61.5% and 47.2%, and miR‐210‐3p were 84.6% and 63.9% for determining AKI.Conclusion: The study’s findings revealed a significant increase in miR‐210‐3p expression in sepsis patients with AKI, indicating its potential as a promising biomarker for determining AKI. This discovery demonstrates that the diagnostic performance of miR‐210‐3p surpasses that of miR‐10a‐5p, providing a more accurate biomarker for diagnosing AKI in sepsis patients.
Predisposition Footprints in the Somatic Genome of Wilms Tumors
Authors: Treger Taryn D. , Wegert Jenny , Wenger Anna , Coorens Tim H.H. , Al-Saadi Reem , Kemps Paul G. , Kennedy Jonathan , Parks Conor , Anderson Nathaniel D. , Hodder Angus , Letunovska Aleksandra , Jung Hyunchul , Ogbonnah Toochi , Trinh Mi K. , Lee-Six Henry , Morcrette Guillaume , van den Heuvel-Eibrink Marry M. , Drost Jarno , van Boxtel Ruben , Bertrums Eline J.M. , Goemans Bianca F. , Antoniou Evangelia , Reinhardt Dirk , Streitenberger Heike , Ziegler Barbara , Bartram Jack , Hutchinson John C. , Vujanic Gordan M. , Vokuhl Christian , Chowdhury Tanzina , Furtwängler Rhoikos , Graf Norbert , Pritchard-Jones Kathy , Gessler Manfred , Behjati Sam 
Published: December 2024

Abstract
Approximately 10% of children with cancer harbor a mutation in a predisposition gene. In children with the kidney cancer Wilms tumor, the prevalence is as high as 30%. Certain predispositions are associated with defined histological and clinical features, suggesting differences in tumorigenesis. To investigate this, we assembled a cohort of 137 children with Wilms tumor, of whom 71 had a pathogenic germline or mosaic variant. We examined 237 neoplasms (including two secondary leukemias), utilizing whole-genome sequencing, RNA sequencing, and genome-wide methylation, validating our findings in an independent cohort. Tumor development differed in children harboring a predisposition, depending on the variant gene and its developmental timing. Differences pervaded the repertoire of driver events, including high-risk mutations, the clonal architecture of normal kidneys, and the relatedness of neoplasms from the same individual. Our findings indicate that predisposition may preordain Wilms tumorigenesis, suggesting a variant-specific approach to managing children merits consideration.
Significance: Tumors that arise in children with a cancer predisposition may develop through the same mutational pathways as sporadic tumors. We examined this question in the childhood kidney cancer, Wilms tumor. We found that certain predispositions dictate the genetic development of tumors, with clinical implications for these children.
See related commentary by Brzezinski and Malkin, p. 258
The C5a/C5aR1 Axis Promotes Migration of Tolerogenic Dendritic Cells to Lymph Nodes, Impairing the Anticancer Immune Response
Authors: Senent Yaiza , Remírez Ana , Repáraz David , Llopiz Diana , Celias Daiana P. , Sainz Cristina , Entrialgo-Cadierno Rodrigo , Suarez Lucia , Rouzaut Ana , Alignani Diego , Tavira Beatriz , Lambris John D. , Woodruff Trent M. , de Andrea Carlos E. , Ruffell Brian , Sarobe Pablo , Ajona Daniel , Pio Ruben 
Published: December 2024

Abstract
The precise mechanisms by which the complement system contributes to the establishment of an immunosuppressive tumor microenvironment and promotes tumor progression remain unclear. In this study, we investigated the expression and function of complement C5a receptor 1 (C5aR1) in human and mouse cancer-associated dendritic cells (DC). First, we observed an overexpression of C5aR1 in tumor-infiltrating DCs, compared with DCs from the blood or spleen. C5aR1 expression was restricted to type 2 conventional DCs and monocyte-derived DCs, which displayed a tolerogenic phenotype capable of inhibiting T-cell activation and promoting tumor growth. C5aR1 engagement in DCs drove their migration from tumors to tumor-draining lymph nodes, where C5a levels were higher. We used this knowledge to optimize an anticancer therapy aimed at enhancing DC activity. In three syngeneic tumor models, C5aR1 inhibition significantly enhanced the efficacy of poly I:C, a Toll-like receptor 3 agonist, in combination with PD-1/PD-L1 blockade. The contribution of C5aR1 inhibition to the antitumor activity of the combination treatment relied on type 1 conventional DCs and antigen-specific CD8+ T cells, required lymphocyte egress from secondary lymphoid organs, and was associated with an increase in IFNγ signaling. In conclusion, our study highlights the importance of the C5a/C5aR1 axis in the biology of cancer-associated DCs and provides compelling evidence for the therapeutic potential of modulating the complement system to enhance DC-mediated immune responses against tumors.
Dynamics of Immune Reconstitution and Impact on Outcomes across CAR-T Cell Products in Large B-cell Lymphoma
Authors: Luan Danny , DeWolf Susan , Fei Teng , Raj Sandeep , Shah Gunjan L. , Lareau Caleb A. , Alhomoud Mohammad , Salles Gilles , Rivas-Delgado Alfredo , Rejeski Kai , Park Jae H. , Luttwak Efrat , Luna de Abia Alejandro , Corona Magdalena , Ntrivalas Evangelos , Cassanello Giulio , Gomez-Llobell Marina , Parascondola Allison , Scordo Michael , Hsu Katharine C. , Palomba M. Lia , Perales Miguel-Angel , Shouval Roni 
Published: December 2024

Abstract
Patients treated with chimeric antigen receptor T-cell (CAR-T) therapy are subject to profound immunosuppression. Dynamics of immune reconstitution (IR) and impacts of IR on outcomes following infusion across CAR-T products are not well understood. In this study, we profiled IR in 263 patients with relapsed/refractory large B-cell lymphoma receiving CAR-T therapy (axicabtagene ciloleucel 44.9%, lisocabtagene maraleucel 30.4%, and tisagenlecleucel 24.7%). Following infusion, patients remain persistently immunosuppressed, with 48.1% having CD4+ T-cell counts &lt;200/µL and the median CD3-CD19+ B-cell counts remaining zero through 1 year after CAR-T therapy. IR differences exist by product, with the fastest CD4+ T-cell recovery seen for tisagenlecleucel, driven primarily by more rapid recovery of the CD4+CCR7−CD45RA− effector memory subset. NK cell, but not CD4+ T cell, recovery is significantly associated with favorable progression-free (HR, 0.65; 95% confidence interval, 0.48–0.88) and overall survival (HR, 0.64; 95% confidence interval, 0.44–0.92) and inversely correlated with inflammatory markers measured at the time of infusion.

Significance:
This study reveals differences in IR patterns after CAR-T therapy in patients with large B-cell lymphoma, with early NK cell recovery emerging as a key predictor of survival. These findings provide potential future avenues of research for improving patient outcomes and tailoring post-therapy management strategies to mitigate relapse risk.
Sex Differences in Cardiovascular-Kidney-Metabolic Syndrome: 30-Year US Trends and Mortality Risks—Brief Report
Authors: Ji Hongwei , Sabanayagam Charumathi , Matsushita Kunihiro , Cheng Ching-Yu , Rim Tyler Hyungtaek , Sheng Bin , Li Huating , Tham Yih-Chung , Cheng Susan , Wong Tien-Yin 
Published: December 2024

BACKGROUND:
The American Heart Association recently published guidelines on how to clinically identify and categorize individuals with cardiovascular-kidney-metabolic (CKM) syndrome. The extent to which CKM syndrome prevalence and prognosis differ by sex remains unknown. This study aimed to examine the impact of sex on trends in prevalence over 30 years and the long-term prognosis of CKM syndrome in the United States.

METHODS:
We analyzed nationally representative National Health and Nutrition Examination Survey 1988 to 2018 data collected from 33 868 US adults (aged ≥20 years) who were under surveillance for all-cause mortality through December 31, 2019. We examined the sex-specific prevalence of CKM syndrome and sex-specific CKM associations with all-cause mortality.

RESULTS:

Of the 33 868 adults studied, the mean±SD age was 48.4±18.3 years with 52% women and 56% non-White. Overall prevalence of CKM syndrome increased steadily from 1988 to 2018 in both sexes, with a larger temporal rise in prevalent stage 3 CKM seen for men (from 18.9% to 22.4%) compared with women (from 13.9% to 15.2%). Over a median follow-up of 13.3 years, there were 8745 deaths. In the multivariable Cox regression analysis, worsening CKM severity was associated with all-cause mortality (
P
<0.001 for both sexes), with greater magnitudes of risk seen in women (hazards ratio, 1.24–3.33) compared with men (hazards ratio, 0.85–2.60) across all stages (likelihood ratio test χ
2
, 19.0;
P
interaction
<0.001); results were similar for cardiovascular mortality (likelihood ratio test χ
2
, 22.3;
P
interaction
<0.001).

CONCLUSIONS:
Women, compared with men, exhibited a lower prevalence of CKM stage 3 but experienced excess mortality risk across the spectrum of multisystem CKM dysfunction. These findings underscore the importance of identifying mechanisms underlying joint cardiovascular, kidney, and metabolic system pathophysiology to close a potentially widening sex disparities gap in multiorgan disease risk.
Applied Systems Aesthetics: Jack Burnham and Contemporary Video Game Art
Authors: Evans Chaz 
Published: December 2024

Abstract
This paper reviews different attempts to recuperate Jack Burnham’s theoretical framework of systems aesthetics, using software as a metaphor for understanding the neo-avant-garde. Rather than recuperate Burnham’s theory to deepen our understanding of post-formalist art of the 20th century, the author suggests applying the systems aesthetics approach to contemporary video game art. This proposal moves Burnham’s metaphorical analysis of software to a material application that can integrate video game artworks with other art traditions. The author argues that video game art is a cogent cultural context for understanding systems aesthetics in the 21st century and that taking up the systems aesthetics approach is critically important for applying arthistorical work to techno-political matters.