bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-wide identification, phylogeny, and expression profiling of RWP-RK gene family under low nitrogen and nodulation in Arabidopsis and legumes
Authors: Wu Zhihua , Liu Hong , Huang Wen , Yi Lisha , Qin Erdai , Li Yarui , Wang Jing , Qin Rui 
Published: January 2020

Abstract
Background Nitrogen, as a constituent of amino acids and nucleic acids, is an essential macronutrient for all living organisms. The nitrogen-fixation clade (NFC) is a clade, consisting of Fabales, Fagales, Cucurbitales, and Rosales, where all nodulating plants have been originated. The plant-specific RWP-RK family of transcription factors are involved in nitrate responses and play specific roles in nodule inception. In the present study, by investigation of RWP-RKs at genome-wide level and comparative coexpression networks, the roles of RWP-RKs involved in nitrate response and nodulation were analyzed to reveal evolution of RWP-RKs and a possible relationship between nitrogen signaling and nodulation.Results Here, we systematically investigated 292 RWP-RKs from 26 species of legumes and non-legumes of NFC by whole-genomic analysis and characterized their evolutionary relationships, protein motifs, and gene structures. We compared RWP-RK networks from Arabidopsis thaliana under N-starvation and N-supplementation conditions, as well as transcriptome atlases from Phaseolus vulgaris and Glycine max . This revealed that N starvation, which is essential for nodulation, alters the connectivity of RWP-RKs to other genes, including symbiosis-related genes. Meanwhile, appropriately low concentrations of nitrates stimulate nodulation by regulating RWP-RK expression in P. vulgaris .Conclusions Our comparative evolutionary analysis of RWP-RKs between A. thaliana and legumes revealed the evolutionary features and the relationship between the nitrate signaling pathway in a model organism and nodulation in legumes.
Quantitative Estimation of Forearm Strength and Associated Muscle Fatigue on the Screw Driving Task
Authors: Hsiao Chih-Kun , Tu Yuan-Kun , Tsai Yi-Jung , Yang Chun-Yuh , Lu Chih-Wei 
Published: January 2020

Abstract
Background: Upper extremity musculoskeletal disorders are highly prevalent work-related injuries. The problem is commonly related to tasks that involve forceful exertion and repetitive motion. This study investigated forearm muscular strength and fatigue when performing a screw driving task using the screw driving model.Methods: Ten male and two female adults participated in this study. The pre- and post-fatigue maximum handgrip, driving torque, push force, insertion rate of the screws and corresponding electromyographic responses were measured to assess the muscle strength loss and fatigue of the forearm when driving screws. Results: After screwing, the maximal grip force, maximal driving torque, and maximal push force losses were approximately 32%, 24% and 27%, respectively. The percentage force loss of grip force and driving torque in the brachioradialis and extensor carpi ulnaris was greater than those of the biceps brachii. The percentage of maximum driving torque and push force decreased significantly on the eighth screw compared with the first screw. The insertion rate decreased linearly with the number of inserted screws; however, a significant decrease in the insertion rate of the fourth screw was observed. Conclusion: Muscle fatigue may occur in subjects who are inserting more than four screws. More muscle force loss and a higher risk of fatigue occurred in the brachioradialis and extensor carpi ulnaris. The results of this study can be used to assess the risk of forearm injury and potential for muscle fatigue due to exposure to repetitive driving tasks. Keywords: muscle fatigue, maximum isometric forces, driving torque
Formulation of integrated water resources management (IWRM) plan at district level: a case study from Bundelkhand region of India
Authors: Goyal V. C. , Garg Anuradha , Patil Jyoti P. , Thomas T. 
Published: January 2020

Abstract
Integrated water resources management (IWRM) is being implemented all over the world, considering its wide area of applications and flexible spatial scale. Scientists have found IWRM useful in an Indian context also where a coordinated development of water and land resources is sought as part of complete economic, social and environmental welfare. The paper presents the concepts of ‘Local IWRM’ planning applied to water conservation and management in a case study of Ur river watershed in Tikamgarh district of Madhya Pradesh (India). The Plan considers effective utilization of land, water and other available natural resources, linked to the vulnerabilities and livelihood opportunities in the geographical area. The IWRM Plan, designed in three sections – (1) water management, (2) land management, and (3) livelihood management – provides specific suggestions on the activities under these three themes as useful inputs to the District Irrigation Plan (DIP) of the Government. The proposed IWRM Plan intends to promote the component of water demand management in district level planning and is envisioned to be an ‘implementable’ planning document for district level government. Acceptability of the IWRM plan is potentially enhanced as the plan was developed through a participatory process, wherein all relevant stakeholders were consulted at different stages of development.
The Structural Role of Gangliosides: Insights from X-ray Scattering on Model Membranes
Authors: Andreev Konstantin 
Published: January 2020

Background:Gangliosides are an essential component of eukaryotic plasma membranes implicated in multiple physiological processes. Little is known about molecular mechanisms underlying the distribution and functions of membrane gangliosides. The overwhelmingly complex organization of glycocalyx impedes the structural analysis on cell surface and the interplay between the lipid components. Advanced X-ray analytical tools applicable to studying biological interfaces call for the simplistic models that mimic ganglioside-enriched cellular membranes.Objective:To summarize the mechanistic evidences of ganglioside interactions with lipid environment and biologically active ligands using high-resolution synchrotron X-ray scattering.Methods:A comprehensive review of studies published over the last decade was done to discuss recent accomplishments and future trends.Results:Langmuir monolayers represent an adequate model system to assess the effect of gangliosides on membrane structure. Grazing incidence X-ray diffraction reveals a condensation effect by gangliosides on zwitterionic phospholipids with the cooperative packing of sialo- and phosphate groups. In turn, the arrangement of negatively charged lipids in ganglioside mixture remains unchanged due to the stretched conformation of carbohydrate moieties. Upon interaction with biological ligands, such as cholera toxin and galectins, the ganglioside redistribution within the ordered regions of monolayer follows distinct mechanistic patterns. The cholera toxin pentamer attached to the oligosaccharide core induces local transition from oblique to the hexagonal lattice resulting in phase coexistence. The incorporation of the A subunit responsible for endocytosis is further promoted by the acidic environment characteristic for endosomal space. X-ray reflectivity shows in-plane orientation of galectin dimers with the spatial mismatch between the lectin binding sites and ganglioside carbohydrates to perturb ceramide alkyl chains. Recent data also demonstrate sialic acid groups to be potential targets for novel peptide mimicking anticancer therapeutics.Conclusion:Coupled with surface X-ray scattering, the membrane mimetic approach allows for better understanding the biological role of gangliosides and their potential applications.
New Inhibition Detection Method to Evaluate the Human Salivary Alphaamylase Activity of Some Drugs, Molecular Docking, and SAR Studies
Authors: Samira Nia , Khedidja Benarous , Manel Lakaas , Israa Sadeki , Mohamed Yousfi 
Published: January 2020

Background:
For the first time, the investigation of six anti-inflammatory drugs and six
antihistaminic drugs for inhibitory activities against alpha-amylase has been evaluated using a new
inhibition detection method in order to find new treatments for some diseases caused by α-amylase.

Objective:
The first part of this work was devoted to the evaluation of the inhibition activity of these
drugs on salivary α-amylase in vitro. Then to study the nature of interactions and structure-activity
relationship, using the Autodockvina program for molecular docking.

Materials and Methods:
The evaluation of the inhibitory activity of our drugs is achieved using a
new method that has proved its sensitivity, quickness, and effectiveness.

Results :
The results of this study show that betamethasone and loratadine are potent α-amylase inhibitors
with IC50 values 0.7mg/ml and 1.03 mg/ml, respectively compared to acarbose with IC50=5.6
μg/ml.

Conclusion:
The results showed that the loratadine and the betamethasone have a strong potential to
inhibit the alpha-amylase.
Mobile Apps to Support Caregiver-Resident Communication in Long-Term Care: Systematic Search and Content Analysis
Authors: Wilson Rozanne , Cochrane Diana , Mihailidis Alex , Small Jeff 
Published: January 2020

Background
In long-term residential care (LTRC), caregivers’ attempts to provide person-centered care can be challenging when assisting residents living with a communication disorder (eg, aphasia) and/or a language-cultural barrier. Mobile communication technology, which includes smartphones and tablets and their software apps, offers an innovative solution for preventing and overcoming communication breakdowns during activities of daily living. There is a need to better understand the availability, relevance, and stability of commercially available communication apps (cApps) that could support person-centered care in the LTRC setting.

Objective
This study aimed to (1) systematically identify and evaluate commercially available cApps that could support person-centered communication (PCC) in LTRC and (2) examine the stability of cApps over 2 years.

Methods
We conducted systematic searches of the Canadian App Store (iPhone Operating System platform) in 2015 and 2017 using predefined search terms. cApps that met the study’s inclusion criteria underwent content review and quality assessment.

Results
Although the 2015 searches identified 519 unique apps, only 27 cApps were eligible for evaluation. The 2015 review identified 2 augmentative and alternative cApps and 2 translation apps as most appropriate for LTRC. Despite a 205% increase (from 199 to 607) in the number of augmentative and alternative communication and translation apps assessed for eligibility in the 2017 review, the top recommended cApps showed suitability for LTRC and marketplace stability.

Conclusions
The recommended existing cApps included some PCC features and demonstrated marketplace longevity. However, cApps that focus on the inclusion of more PCC features may be better suited for use in LTRC, which warrants future development. Furthermore, cApp content and quality would improve by including research evidence and experiential knowledge (eg, nurses and health care aides) to inform app development. cApps offer care staff a tool that could promote social participation and person-centered care.

International Registered Report Identifier (IRRID)
RR2-10.2196/10.2196/17136
O (ab)uso da palavra fascimo: a recepção de Tropa de Elite
Authors: Caldas Pedro 
Published: January 2020

Este ensaio considera a recepção do filme Tropa de elite, de José Padilha. O filme suscitou uma acalorado debate na imprensa brasileira, que em parte o acusou de fascista, enquanto seus defensores argumentaram que se tratava de um retrato realista da corrupção policial e degradação social no Rio de Janeiro. Meu principal objetivo é, então, analisar como a palavra “fascista” foi (ab)usada por ambos os lados.
Embora não defenda a idéia de que o filme de Padilha seja fascista, posto que não se enquadra em nenhuma definição de uma obra de arte fascista, sugerirei também que ele não é um mero quadro formado por meio da perspectiva de um policial, uma vez que contém procedimentos e técnicas naturalistas. Neste sentido, Tropa de elite é ainda mais problemático do que sua alegada apologia fascista.
PERUBAHAN STRUKTUR DAN ARRANSEMEN MUSIK GAMAD DI KOTA PADANG
Authors: Fikri Ioqo Alhamra , Ardipal Ardipal 
Published: January 2020

AbstrakMusik Gamad merupakan sebuah kesenian khas dari kota Padang yang mana pada dasarnya secara musikologi kesenian ini masih tergolong dalam klasifikasi musik melayu namun memiliki keunikan tersendiri dikarenakan pantun-pantun yang menjadi syair lagu dinyanyikan dalam bahasa Minangkabau dan juga bersifat spontan.kesenian ini juga merupakan sebuah bentuk akulturasi dari beberapa budaya masyarakat yang ada di kota padang pada era perkembanganya hingga pada saat ini.dilatar belakangi oleh kedatangan bangsa portugis dengan budaya musik barat dengan cepat menjadi daya tarik bagi bumi putra dalam konsep bermain musik sehingga pada sebelumnya pantun hanya dinyanyikan oleh vokal dengan iringan gendang tradisional kemudian bertambah dengan alat musik seperti akordeon,biola dan gitar.musik gamad pun dengan cepat menjadi sebuah kesenain yang populer di kota padang,namun dengan seiring perkembangan zaman dan pergeseran nilai-nilai sosial yang terjadi dalam masyarakat kota padang turut mempengaruhi kesenian ini sehingga terjadilah perubahan struktur dan bentuk dalam arransemen musik gamad di kota Padang. Kata Kunci: gamad, struktur, bentuk, arransemen.AbstractGamad music is a distinctive art from the city of Padang, which is basically a musical artistry is still classified in the Malay music classification but has its own uniqueness because the poems are poetry sung in the Minangkabau language and are also spontaneous. This art is also a form acculturation of several cultural communities in the city of Padang in the era of its development until today. The background of the arrival of the Portuguese with Western music culture quickly became an attraction for the son of the earth in the concept of playing music so that in the past pantun was only sung by vocals with accompaniment traditional drum and then increased with musical instruments such as accordions, violins and guitars. Gamad music also quickly became a popular game in the city of Padang, but with the development of the times and the shifting of social values that occur in the city of Padang society also influence to this art so that there was a change in structure and shape in the gamad music arrangement in the city of Padang.Keywords: gamad, structure, shape, arrangement.
THE EFFECT OF AEROBIC EXERCISE TO THE WEIGHT REDUCTION OF CIVIL SERVANTS WHICH HAVE OVERWEIGHT IN THE EDUCATION OFFICE OF NORTH SUMATERA
Authors: Surbakti Sabar , Nella Dika 
Published: January 2020

The purpose of this study was to determine whether there was an effect of aerobic exercise on weight loss of Civil Servants who are overweight in the Education Office of North Sumatra. This study used an experimental method which was giving treatment to the sample. The treatment given was in the form of aerobic exercise where the study was lasted for 6 weeks. This study used a pre-test and post-test one group design research design. The population in this study was the State Civil Apparatus in the Education Office of North Sumatra, the PMPTK (Development of Education Quality and Education Personnel Quality) totaling 30 people, 16 women and 14 min, then the research sample was determined by means of a proportional sampling which was sampling using some criteria. Based on these criteria a sample of 10 people was obtained. To test the hypothesis needed research data was obtained through research instruments. The instrument / research used a weight and height scale, the data analysis technique used the t-test statistic with a significance level of 0.05. From the results of the analysis data obtained weight loss with an average of 3.58 with a t-value of 13.6 ~> at Db 9 with a confidence level of 0.05 t-table value was 1.83. T-count t-table (13,671,83), then Ho was rejected and Ha was accepted. Then it was concluded that aerobic exercise gave a significant effect on weight loss in the State Civil Apparatus which was overweight in the Education Office of North Sumatra.
The Relevance of Project-Based Lecture in Industrial Revolution 4.0 : Meta – Synthesis Study
Authors: Rokhmawan Tristan , Wulandari Badriyah 
Published: January 2020

The researchers conducted a meta-synthesis study of the concept of project-based lectures and the concepts of the development of the IR 4.0 era. The main goal of this study was to examine a rational relationship or relevance between the application of project-based lectures and the development of the educational paradigm in the Industiral Revolution (IR) 4.0 era. The result showed that the seventh project-based lecture features can realize the educational context in the IR 4.0 era. The result Meta-Synthesis in two concepts found seven relevances, namely: 1) Real study and essential supporting in freedom learning, broader learning context 2) Bureaucratic learning, relevant life to support freedom learning. 3) Learning inquiry based on investigative, complex to support students’ independence in learning. 4) Meaningful, social, and collaborative learning to support learning resources and good cooperation in learning. 5) Real-work learning and remember the process, supporting the contextuality and meaningful learning process. 6) Authentic learning and interdisciplinary, supporting the breadth and flexibility in developing knowledge accordance with the world developments. 7) Collaborative learning teachers, supporting of learning partnerships.
Keywords: Project-Based Lectures, Industrial Revolution 4.0, Meta-Sythesis Study
Two cases of symptomatic common carotid artery occlusion treated by carotid endarterectomy with L-shaped ministernotomy
Authors: Ogawa Shotaro , Ohgaki Fukutaro , Mizuta Ryosuke , Furuta Yasuyuki , Fujitani Shigeta , Fujimoto So , Ota Takahiro 
Published: January 2020

Background:
Common carotid artery occlusion (CCAO) is rare. Symptomatic lesions are resistant to medical treatment and revascularization are often required, but there is no consensus on the treatment of CCAO. In this paper, two cases of symptomatic CCAO treated by carotid endarterectomy (CEA) with L-shaped ministernotomy, in which the lesions extended to the beginning part of the CCA, are reported.

Case Description:
Case 1 involved a 74-year-old man who presented with transient left limb numbness and an abnormal right visual field. Cerebrovascular angiography showed that the right CCA was occluded immediately after its origin and blood was supplied from the posterior circulation. CEA was performed with an L-shaped ministernotomy that allowed exposure of the CCA origin with minimal invasion. There were no complications associated with the sternal incision and he was discharged with a modified Rankin Scale (mRS) score of 0. Case 2 involved a 70-year-old man who presented with left half-blindness. Magnetic resonance imaging showed infarction in the right posterior cerebral artery region and neck echo showed CCA pseudo occlusion just before the carotid bulb. A new infarction in the right middle cerebral artery region developed during hospitalization. CEA with partial sternotomy was performed. The patient was rehabilitated with no deterioration of neurological findings and transferred with an mRS score of 3.

Conclusion:
There were no complications resulting from partial sternotomy in the two cases presented. CEA with partial sternotomy could be an effective treatment option for CCAO in which the internal carotid artery is patent and thrombus extends to the proximal CCA.
Tratamiento quirúrgico de las fracturas laterales de clavícula. Un nuevo concepto
Authors: Del Gordo-D'Amato Roberto Joaquín , Acuña-Pinilla José , Torres-Carrillo Efrén Camilo 
Published: January 2020

Introducción: El tercio lateral de la clavícula resulta el segundo de mayor afectación, después del tercio medio en patología fracturaria y el tratamiento de estas lesiones día a día migra hacia el tratamiento quirúrgico en razón a que la mayoría resultan con grandes desplazamientos. Objetivo: Determinar si la reducción abierta y fijación interna de las fracturas de clavícula con placas de extensión lateral representan una alterativa en el tratamiento para este tipo de lesiones.Metodología: Se presenta un estudio de cohorte prospectivo, en el cual 36 pacientes fueron intervenidos quirúrgicamente por fracturas laterales de clavícula en el periodo comprendido entre abril de 2011 y septiembre de 2012, mediante reducción abierta y fijación interna con placa anatómica bloqueada con extensión lateral (LCP) para clavícula. De los treinta y seis pacientes intervenidos, fueron realizados seguimientos completos aplicando la escala análoga visual de dolor (VAS) y la escala funcional de Constant, a las seis semanas, tres meses, seis meses y al año posoperatorio.Resultados: Se pudo mostrar que hubo cambios progresivos en la mejora del dolor y funcionalidad en cada uno de los periodos de seguimiento a partir de la sexta semana posoperatoria con evidencia significativa (p<0.001) y sin cambios en la calificación del dolor entre el sexto mes y el año de seguimiento (p= 0.083).Conclusiones: Se puede concluir que la reducción abierta y fijación interna de las fracturas de clavícula con placas de extensión lateral representan una excelente alternativa de tratamiento para este tipo de lesiones, con pronta y completa recuperación funcional y baja probabilidad de complicaciones. [Del Gordo RJ, Acuña J, Torres E. Tratamiento quirúrgico de las fracturas laterales de clavícula. Un nuevo concepto. MedUNAB 2015; 17(2):91-98]
Adultos jóvenes: población en riesgo para iniciar el consumo de tabaco
Authors: Vásquez Pinto Luis Enrique 
Published: January 2020

El fumar tabaco es la principal causa de mortalidad prevenible en el mundo. Se estima que para el año 2030 el consumo de tabaco será la causa de 8 millones de muertes anualmente; el 80% de estas ocurrirán en países en desarrollo como Colombia (1). Según datos de la Organización Mundial de la Salud, el 25% de los adolescentes tiene su primer contacto con el cigarrillo durante el colegio, y de estos un 20% desarrollarán dependencia a la nicotina (2-5). El aumento en la tasa de fumadores en los últimos años se encuentra en relación con el aumento del consumo en la población adolescente y adulta joven, lo cual probablemente esté en relación con lo promovido por las empresas tabacaleras quienes han cambiado su población de enfoque hacia los jóvenes (6). En nuestro país, la Encuesta Mundial de Tabaquismo que se llevó a cabo en las principales ciudades del país, mostró una prevalencia del 29.8% de fumadores en estudiantes de secundaria (4). Sin embargo, según estos datos se puede inferir que existe un amplio porcentaje de población adulta joven, principalmente entre la edad de 17-21 años conocido como la adolescencia tardía (7), que se encuentra terminando secundaria e iniciando estudios universitarios o vida laboral y quienes aún persisten en riesgo de adquirir el hábito de fumar; por lo tanto la implementación de políticas sanitarias preventivas que apunten a esta población son necesarias en nuestro país y a nivel mundial. Esta carta al editor tiene como finalidad generar conciencia y alertar sobre la importancia del impacto del consumo de tabaco en la población universitaria o de adultos jóvenes, así como de los factores que están asociados a este proceso mencionando experiencias y evidencia local.