bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurocognitive and Psychiatric Markers for Addiction: Common vs. Specific Endophenotypes for Heroin and Amphetamine Dependence
Authors: Long Elizabeth C. , Kaneva Radka , Vasilev Georgi , Moeller F. Gerard , Vassileva Jasmin 
Published: January 2020

Background:
The differential utility of neurocognitive impulsivity and externalizing/
internalizing traits as putative endophenotypes for dependence on heroin vs. amphetamine is unclear.

Objective:
This exploratory study aims to determine: (1) whether neurocognitive impulsivity dimensions
and externalizing/internalizing traits are correlated between siblings discordant for heroin and amphetamine
dependence; and (2) which of these associations are common across substances and which are substance-
specific.

Methods:
Pearson correlations between individuals with ‘pure’ heroin and amphetamine dependence and
their unaffected biological siblings (n = 37 heroin sibling pairs; n = 30 amphetamine sibling pairs) were
run on 10 neurocognitive measures, 6 externalizing measures, and 5 internalizing measures. Sibling pair
effects were further examined using regression.

Results:
Siblings discordant for heroin dependence were significantly correlated on delay aversion on the
Cambridge Gambling Task, risk-taking on the Balloon Analogue Risk Task, sensation seeking, and hopelessness.
Siblings discordant for amphetamine dependence were significantly correlated on the quality of
decision-making on the Cambridge Gambling Task, discriminability on the Immediate Memory Task,
commission errors on the Go/No Go Task, trait impulsivity, ADHD and anxiety sensitivity.

Conclusion:
Dimensions of impulsivity and externalizing/internalizing traits appear to aggregate among
siblings discordant for substance dependence. Risk-taking propensity, sensation seeking and hopelessness
were specific for heroin sibling pairs. Motor/action impulsivity, trait impulsivity, and anxiety sensitivity
were specific to amphetamine sibling pairs. Decisional/choice impulsivity was common across both heroin
and amphetamine sibling pairs. These findings provide preliminary evidence for the utility of neurocognitive
impulsivity and externalizing/ internalizing traits as candidate endophenotypes for substance
dependence in general and for substance-specific dependencies.
Herbal Medicine for Glioblastoma: Current and Future Prospects
Authors: Khan Imran , Mahfooz Sadaf , Hatiboglu Mustafa A. 
Published: January 2020

Background:
Glioblastoma is one of the most aggressive and devastating tumours of
the central nervous system with short survival time. Glioblastoma usually shows fast cell proliferation
and invasion of normal brain tissue causing poor prognosis. The present standard of care in
patients with glioblastoma includes surgery followed by radiotherapy and temozolomide (TMZ)
based chemotherapy. Unfortunately, these approaches are not sufficient to lead a favorable prognosis
and survival rates. As the current approaches do not provide a long-term benefit in those patients,
new alternative treatments including natural compounds, have drawn attention. Due to their
natural origin, they are associated with minimum cellular toxicity towards normal cells and it has
become one of the most attractive approaches to treat tumours by natural compounds or phytochemicals.

Objective:
In the present review, the role of natural compounds or phytochemicals in the treatment
of glioblastoma describing their efficacy on various aspects of glioblastoma pathophysiology such
as cell proliferation, apoptosis, cell cycle regulation, cellular signaling pathways, chemoresistance
and their role in combinatorial therapeutic approaches was described.

Methods:
Peer-reviewed literature was extracted using Pubmed, EMBASE Ovid and Google
Scholar to be reviewed in the present article.

Conclusion:
Preclinical data available in the literature suggest that phytochemicals hold immense
potential to be translated into treatment modalities. However, further clinical studies with conclusive
results are required to implement phytochemicals in treatment modalities.
Mitigating Perspectives of Asiatic Acid in the Renal Derangements of Streptozotocin-Nicotinamide Induced Diabetic Rats
Authors: Kalidhindi Swapna , Uddandrao Veera Venkata Sathibabu , Sasikumar Vadivukkarasi , Raveendran Nivedha , Ganapathy Saravanan 
Published: January 2020

Background:The present study was conducted to evaluate the mitigating effects of Asiatic Acid (AA), on the changes in carbohydrate metabolism, insulin signaling molecules and renal function markers in Streptozotocin (STZ)-Nicotinamide (NAD) induced diabetic rats.Methods:AA (20 mg/kg BW) was supplemented orally to the diabetic rats for 42 days. The levels of plasma glucose, Hemoglobin (Hb), glycosylated hemoglobin (HbA1c) insulin and renal function markers, carbohydrate metabolic enzymes in the kidney and insulin signaling molecules in skeletal muscle were measured.Results:The administration of AA elicited a significant decrease in the levels of plasma glucose, insulin resistance, HbA1c, urea, uric acid, creatinine, glycogen, glycogen synthase, glucose-6- phosphatase, and fructose-1,6-bisphosphatase and a significant increase of body weight development, insulin, Hb, hexokinase, and glycogen phosphorylase and mRNA expressions of insulin signaling molecule like insulin receptor 1, insulin receptor 2 and glucose transporter-4 in the STZ-NAD induced diabetic rats. Further, the protective effect of AA was evidenced by its histological annotation of the kidney tissues.Conclusion:Hence, this study concluded that AA can protect against renal dysfunction by attenuating carbohydrate metabolic disorder and subsequently enhances glucose utilization and renal function in STZ-NAD-induced diabetic rats.
The Role of Leukotrienes Inhibitors in the Management of Chronic Inflammatory Diseases
Authors: Meshram Deepak , Bhardwaj Khushbo , Rathod Charulata , Mahady Gail B. , Soni Kapil K. 
Published: January 2020

Background:
Leukotrienes are powerful mediators of inflammation and interact with specific
receptors in target cell membrane to initiate an inflammatory response. Thus, Leukotrienes (LTs)
are considered to be potent mediators of inflammatory diseases including allergic rhinitis, inflammatory
bowel disease and asthma. Leukotriene B4 and the series of cysteinyl leukotrienes (C4, D4, and E4) are
metabolites of arachidonic acid metabolism that cause inflammation. The cysteinyl LTs are known to
increase vascular permeability, bronco-constriction and mucus secretion.

Objectives:
To review the published data for leukotriene inhibitors of plant origin and the recent patents
for leukotriene inhibitors, as well as their role in the management of inflammatory diseases.

Methods:
Published data for leukotrienes antagonists of plant origin were searched from 1938 to 2019,
without language restrictions using relevant keywords in both free text and Medical Subject Headings
(MeSH terms) format. Literature and patent searches in the field of leukotriene inhibitors were carried
out by using numerous scientific databases including Science Direct, PubMed, MEDLINE, Google
Patents, US Patents, US Patent Applications, Abstract of Japan, German Patents, European Patents,
WIPO and NAPRALERT. Finally, data from these information resources were analyzed and reported
in the present study.

Results:
Currently, numerous anti-histaminic medicines are available including chloropheneremine,
brompheniramine, cetirizine, and clementine. Furthermore, specific leukotriene antagonists from allopathic
medicines are also available including zileuton, montelukast, pranlukast and zafirlukast and are
considered effective and safe medicines as compared to the first generation medicines. The present
study reports leukotrienes antagonistic agents of natural products and certain recent patents that could
be an alternative medicine in the management of inflammation in respiratory diseases.

Conclusion:
The present study highlights recent updates on the pharmacology and patents on leukotriene
antagonists in the management of inflammation respiratory diseases.
Mesenchymal Stem Cell-Mediated Immuno-Modulatory and Anti- Inflammatory Mechanisms in Immune and Allergic Disorders
Authors: Gugjoo Mudasir B. , Hussain Shahid , Amarpal  , Shah Riaz A. , Dhama Kuldeep 
Published: January 2020

Background:
Mesenchymal Stem Cells (MSCs) are present in almost all the tissues of the
body and act as the backbone of the internal tissue homeostasis. Among their various characteristic
features, immuno-modulatory and/ anti-inflammatory properties play an important role in therapeutics.

Objective:
The current topic focuses on the characterization and immuno-modulatory and/ antiinflammatory
properties of MSCs. To present and discuss the current status of MSCs immunomodulatory
properties.

Methods:
Available literature on MSCs properties and patents have been detailed, critically interpreted,
and discussed based upon available literature. The main focus has been on their characteristic immunomodulatory
and anti-inflammatory properties though some of the basic characterization markers have
also been detailed. The databases searched for the literature include PubMed, Med Line, PubMed Central,
Science Direct and a few other scientific databases.

Results:
MSCs are present in a very limited concentration in the tissues, and as such their culture expansion
becomes imperative. MSCs immuno-modulatory and anti-inflammatory roles are achieved
through direct cell-cell contact and / by the release of certain factors. Such properties are controlled by
micro-environment upon which currently very limited control can be exerted. Besides, further insights
in the xeno-protein free culture media as against the fetal bovine serum is required.

Conclusions:
MSCs have been well-isolated, cultured and characterized from numerous tissues of the
body. The majority of the studies have shown MSCs as immuno-compromised with immunomodulatory
and / or anti-inflammatory properties except some of the latest studies that have failed to achieve
the desired results and thus, demand further research. Further research is required in the area to translate
the results into clinical application.
The Factors of the Holistic Health Status of Thai Elders in the 21st Century
Authors: Ruchiwit Manyat , Phanphairoj Kanjanee , Sumneangsanor Tipsuda , Mamom Jinpitcha 
Published: January 2020

Background:
Holistic health is important for life, perhaps especially for elders. Focus
should not only be placed on illness or the physical part of their lives, but the person as a whole
should also be considered, emphasizing the connection of their mind, body, and the environment.

Objective:
The aims of this research were to study the factors of the Holistic Health Status (HHS)
of the Thai elderly in the 21st century, and to predict the factors affecting the development of HHS
from 3 aspects; physical health status, mental and emotional health status, and the social and environmental
health status.

Method:
The data were collected from 928 Thai elderly aged 60 and over in the central part of
Thailand. The research instrument was a questionnaire whose reliability was confirmed using a
Cronbach alpha coefficient of .904. Multiple regression analysis was used for predicting the factors
of HHS.

Results:
The results indicated that stress, increased age, gender, and social participation can predict
the HHS of Thai elders, and stress can predict each of the 3 aspects. Therefore, stress prevention
activities are very important for enhancing the HHS of Thai elders.

Conclusion:
The findings of this research can be used to improve the quality of life of elders in the
21st century.
Electrospun Cellulose Acetate Nanofiber Morphology and Property Derived from CaCl2-Formic Acid Solvent System
Authors: Liu Zhi , Xu Ningli , Ke Huizhen , Zhou Lei 
Published: January 2020

Background:
Electrospun Cellulose Acetate (CA) nanofibrous membrane can be used in
many areas such as biomedicine, water treatment. However, due to the strong hydrogen-bond interaction,
the rare solvent can dissolve the CA and the resulting CA nanofibrous membranes always show
bad morphology and poor performance.

Aims:
To research the effect of CaCl2-Formic acid (CaCl2-FA) solvent system on the morphology and
structure of CA nanofibrous membrane.

Methods:
CA nanofibrous membrane was fabricated with a two-step dissolution method using the first
step of CaCl2-FA solvent system followed by the second step of FA solvent solely. Subsequently, the
CA nanofibrous membrane morphology and structure property were systematically investigated.

Results and Conclusion:
The results show that the CaCl2-FA can dissolve the CA efficiently. Additionally,
the regenerated CA nanofibers are well-formed under all the CA concentrations with controlling
fiber diameter ranging from 224.9 ± 38.6 nm to 367.8 ± 80.4 nm. The results suggest that this
two-step dissolution method can be an effective and alternative approach to dissolve CA and regenerate
CA nanofibrous membrane.
Novel Scaffolds for Leishmania infantum Trypanothione Reductase Inhibitors Derived from Brazilian Natural Products Biodiversity
Authors: da Paixão Vinícius Guimarães , da Rocha Pita Samuel Silva 
Published: January 2020

Background:Leishmania infantum causes the most lethal form of Leishmaniasis: Visceral leishmaniasis. Current therapy for this disease is related to the development of drug-resistant species and toxicity. Trypanothione Reductase (LiTR), a validated target for the drug discovery process, is involved with parasites' thiol-redox metabolism.Objective:In this study, through Virtual Screening employing two distinct Natural Products Brazilian databases, we aimed to identify novel inhibitor scaffolds against LiTR.Results:Thus, the “top 10” LiTR-ligand energies have been selected and their interaction profiles into LiTR sites through the AuPosSOM server have been verified. Finally, Pred-hERG, Aggregator Advisor, FAF-DRUGS, pkCSM and DataWarrior were employed and their results allowed us to evaluate, respectively, the cardiotoxicity, aggregation capacity, presence of false-positive compounds (PAINS) and their toxicities.Conclusion:Three molecules that overcame the in silico pharmacokinetic analysis and have a good interaction with LiTR, were chosen to use in vitro assays hoping that our computational results reported here would aid the development of new anti-leishmanial compounds.
ÖZ YETERLİK VE GERİBİLDİRİM ARASINDAKİ İLİŞKİ: FEN ALANLARI ÖĞRETMEN ADAYLARI ÜZERİNE BİR ARAŞTIRMA
Authors: Akkuzu Güven Nalan , Uyulgan Melis Arzu 
Published: January 2020

Bu çalışma öğretmen adaylarının
öz yeterlik inançları ile geribildirim arasındaki ilişkiyi tespit etmeyi ve
oluşabilecek davranış değişikliğini anlayabilmede öz yeterlik inançlarının
geribildirim türü, sıklığı, ders deneyim saati gibi çeşitli değişkenlerle olan
ilişkilerini belirlemeyi amaçlamaktadır. Araştırmanın örneklemini, bir devlet
üniversitesinin 2014-2015 ve 2015-2016 öğretim yılları Bahar dönemlerinde
Matematik ve Fen Bilimleri Eğitimi Bölümü’nde Fizik, Kimya ve Biyoloji Eğitimi
Anabilim Dalları'nda öğrenim gören son sınıf öğretmen adayları (N=102)
oluşturmaktadır. Araştırmada kullanılan veri toplama araçları kişisel bilgi
formu, Fen Alanları (Fizik, Kimya,
Biyoloji) Öğretimi Öz yeterlik İnanç Ölçeği ve Geribildirim Ölçeği’dir. Verilerin analizinde ortalama, standart sapma, ANOVA,
korelasyon analizleri kullanılmıştır. Araştırma sonuçları; öğretmen
adaylarının fen alanları öğretimi öz yeterlikleri bakımından yüksek düzeyde öz
yeterlik inancına sahip olduklarını ortaya koymaktadır. Geribildirim ölçeğinde
ise mesleki gelişim boyutunda yüksek puanların ortaya çıkması geribildirimin
öğretmen adaylarının mesleki yeterliliklerini ve performanslarını
değerlendirmede önem taşıdığını göstermektedir.
Ayrıca, öğretmen adaylarının öz yeterlik puanları geribildirim türü,
sıklığı ve ders deneyim saatlerindeki değişimlerde anlamlı fark göstermektedir.
ÜNİVERSİTE ÖĞRENCİLERİNİN BENLİK AYRIMLAŞMASI, ÖZGECİLİK, İÇ-DIŞ KONTROL ODAĞI VE POZİTİF-NEGATİF DUYGU DÜZEYLERİ ARASINDAKİ İLİŞKİLERİN İNCELENMESİ
Authors: Mert Abdullah , Kahraman Meliha 
Published: January 2020

Bu çalışmada, üniversite öğrencilerinin
benlik ayrımlaşması, özgecilik, iç-dış kontrol odağı ve pozitif-negatif duygu
düzeyleri arasındaki ilişkilerin incelenmesi amaçlanmaktadır. Araştırmanın örneklemi,
2018-2019 eğitim-öğretim yılında, Uşak Üniversitesi, Eğitim Fakültesi’nin
çeşitli bölümlerinde öğrenim görmekte olan ve araştırmaya gönüllü olarak
katılmayı kabul eden 196’sı kız (%61,8), 121’i erkek (%38,2) olmak toplam 317
üniversite öğrencisinden oluşmaktadır. Katılımcıların benlik ayrımlaşması düzeylerini
ölçmek amacıyla “Benlik Ayrımlaşması Ölçeği” (BAÖ), kontrol odağını belirlemek
amacıyla “Rotter’in İç-Dış Kontrol Odağı Ölçeği (RİDKOÖ), özgecilik düzeylerini
ölçmek amacıyla “Özgecilik Ölçeği” (ÖÖ)
ve pozitif ve negatif duyguyu ölçmek amacıyla “Pozitif ve Negatif Duygu
Ölçeği” (PNDÖ) kullanılmıştır. Bağımsız değişkenlerin benlik ayrımlaşmasını açıklama
düzeyini belirlemek amacıyla aşamalı regresyon analizi yapılmıştır. Özgeciliğin
ve pozitif ve negatif duyguların tüm boyutları birlikte alt boyutlarının
birlikte benlik farklılaşmasını istatistiksel olarak anlamlı şekilde yordadığı
görülmüştür. Üniversite öğrencilerinin iç ve dış kontrol odağının şans ve
kişiler arası dış kontrol alt boyutu dışında benliğe ilişkin farklılaşmada bir
etkisinin olmadığını tespit edilmiştir. Elde edilen bulgular, alan yazın kapsamında
tartışılmış ve çeşitli önerilerde bulunulmuştur.
Online EFL Assignments and Success
Authors: Yalçın Ahmet , Şevik Mustafa 
Published: January 2020

Giving homework is a common practice at all levels of education, yet its
impact as a pedagogical tool on the learning process is still a matter of
debate. The past decade has seen the rapid development of web-based tools
created for educational purposes. In parallel with these developments,
researchers and educators have begun to show an increased interest in online
homework systems in recent years in order to evaluate learning and to overcome
the drawbacks of pen-and-paper homework. This study aims to investigate the
effects of online English as a Foreign Language (EFL) assignments on student
success in a university vocational
school context. Participants of this experimental study were 49 first-grade
students studying at Burdur Mehmet Akif Ersoy University (MAKU) Gölhisar
Vocational School (GVS). Of these students, 28 constituted the experimental
group and 21 constituted the control group. The study was conducted in the
spring term of the 2016-2017 academic year for a 12-week period. At the
beginning of the study, a pre-test was applied to both groups. Next, five
weekly assignments were given for the experimental group via Edmodo and for the
control group as pen-and-paper homework. The effect of the assignments on
student success was determined by comparing the two groups’ pre-test and
post-test results using quantitative methods. The findings revealed that
assignments whether online or pen-and-paper increased students' success significantly.
Moreover, the success improvement of the students who did online assignments
was about double that of the students who were responsible for doing
pen-and-paper assignments. The study concluded with suggestions that EFL
teachers should give assignments in university vocational schools and that
these assignments should be given as online since they are more effective on
student success.
Street Design and Human Behaviour Factors towards a Safe Urban Environment for Women
Authors: Abdul Rahman Norhafizah , Ali Maimon , Ghani Izham 
Published: January 2020

Integrating women safety in the urban street environment is critical in creating good quality living to improve living standard. This paper discusses women’s needs and characteristics of urban streets that can affect women’s behaviour. The objectives of this paper are to identify the characters of urban environment in making streets safe for women and establishing the characteristics of safe urban street environment for women. This study is conducted using mixed methodology to identify the relationship between urban street design and women’s behaviour. This paper will contribute towards safe urban street design with an excellent urban environment and dynamic economic activities. Keywords: women safety; urban design; safe cities; behavioural study eISSN: 2398-4295 © 2019. The Authors. Published for AMER, ABRA & cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI:http://dx.doi.org/10.21834/ajbes.v4i17.184
The Most-Cited Authors Who Published Papers in JMIR mHealth and uHealth Using the Authorship-Weighted Scheme: Bibliometric Analysis
Authors: Kan Wei-Chih , Chou Willy , Chien Tsair-Wei , Yeh Yu-Tsen , Chou Po-Hsin 
Published: January 2020

Background
Many previous papers have investigated most-cited articles or most productive authors in academics, but few have studied most-cited authors. Two challenges are faced in doing so, one of which is that some different authors will have the same name in the bibliometric data, and the second is that coauthors’ contributions are different in the article byline. No study has dealt with the matter of duplicate names in bibliometric data. Although betweenness centrality (BC) is one of the most popular degrees of density in social network analysis (SNA), few have applied the BC algorithm to interpret a network’s characteristics. A quantitative scheme must be used for calculating weighted author credits and then applying the metrics in comparison.

Objective
This study aimed to apply the BC algorithm to examine possible identical names in a network and report the most-cited authors for a journal related to international mobile health (mHealth) research.

Methods
We obtained 676 abstracts from Medline based on the keywords “JMIR mHealth and uHealth” (Journal) on June 30, 2018. The author names, countries/areas, and author-defined keywords were recorded. The BCs were then calculated for the following: (1) the most-cited authors displayed on Google Maps; (2) the geographical distribution of countries/areas for the first author; and (3) the keywords dispersed by BC and related to article topics in comparison on citation indices. Pajek software was used to yield the BC for each entity (or node). Bibliometric indices, including h-, g-, and x-indexes, the mean of core articles on g(Ag)=sum (citations on g-core/publications on g-core), and author impact factor (AIF), were applied.

Results
We found that the most-cited author was Sherif M Badawy (from the United States), who had published six articles on JMIR mHealth and uHealth with high bibliometric indices (h=3; AIF=8.47; x=4.68; Ag=5.26). We also found that the two countries with the highest BC were the United States and the United Kingdom and that the two keyword clusters of mHealth and telemedicine earned the highest indices in comparison to other counterparts. All visual representations were successfully displayed on Google Maps.

Conclusions
The most cited authors were selected using the authorship-weighted scheme (AWS), and the keywords of mHealth and telemedicine were more highly cited than other counterparts. The results on Google Maps are novel and unique as knowledge concept maps for understanding the feature of a journal. The research approaches used in this study (ie, BC and AWS) can be applied to other bibliometric analyses in the future.