bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medical care in armed conflict: Perpetrator discourse in historical perspective
Authors: McLean Duncan 
Published: February 2020

AbstractAlthough the Geneva Conventions have been successively revised since 1864, norms regarding the protection of medical care have been frequently disregarded. Despite current claims of international humanitarian law in crisis, comparing historic levels of violations with contemporary incidents is quantitatively challenging. Reviewing past reactions and justifications used by perpetrators of attacks on medical care can, however, be revealing. Based on a series of emblematic cases, qualitative analysis of perpetrator discourse can contribute to a better understanding of why the protection of medical care in armed conflict continues to be problematic to this day, notably through the rationales given for attacks, which have remained remarkably consistent over time.
Heritability of Curve Patterns in Oral Glucose Tolerance Test
Authors: Dalgård Christine , Möller Soren , Kyvik Kirsten O. 
Published: February 2020

AbstractType 2 diabetes, which is caused by both genetic and environmental factors, may be diagnosed using the oral glucose tolerance test (OGTT). Recent studies demonstrated specific patterns in glucose curves during OGTT associated with cardiometabolic risk profiles. As the relative contribution of genetic and environmental influences on glucose curve patterns is unknown, we aimed to investigate the heritability of these patterns. We studied twins from the Danish GEMINAKAR cohort aged 18–67 years and free from diabetes at baseline during 1997–2000; glucose concentrations were measured three times during a 2-h OGTT. Heterogeneity of the glucose response during OGTT was examined with latent class mixed-effects models, evaluating goodness of fit by Bayes information criterion. The genetic influence on curve patterns was estimated using quantitative genetic modeling based on linear structural equations. Overall, 1455 twins (41% monozygotic) had valid glucose concentrations measured from the OGTT, and four latent classes with different glucose response patterns were identified. Statistical modeling demonstrated genetic influence for belonging to a specific class or not, with heritability estimated to be between 45% and 67%. During ∼12 years of follow-up, the four classes were each associated with different incidence of type 2 diabetes. Hence, glucose response curve patterns associated with type 2 diabetes risk appear to be moderately to highly heritable.
The Cauchy 5 Small, Low‐Volume Lunar Shield Volcano: Evidence for Volatile Exsolution‐Eruption Patterns and Type 1/Type 2 Hybrid Irregular Mare Patch Formation
Authors: Qiao Le , Head James W. , Wilson Lionel , Ling Zongcheng 
Published: February 2020

AbstractThe lunar shield volcano Cauchy 5, sitting at the low diameter‐height‐volume end of the population, is the only known example containing two different types of Irregular Mare Patches (IMPs) in very close association: (1) the pit crater interior Type 1 IMP composed of bleb‐like mounds surrounded by a hummocky and blocky floor unit and (2) Type 2 IMPs, small, often optically immature pits less than ~5 m deep, located on the generally block‐deficient shield flanks. A four‐phase lunar magma ascent/eruption model predicts that during a relatively brief eruption, low magma rise rates maximize volatile exsolution in lava filling the pit crater. Bubble‐rich magmas overtop the pit crater and form extremely vesicular flows on the shield flanks. Exposure of the flanking flows to vacuum produces a fragmental layer of exploded glassy bubble walls. Subsequent second boiling upon cooling of the flanking flow interiors releases additional volatiles which migrate and collect, forming magmatic foams and gas pockets. As magma rise rates slow, trapped gas and magmatic foam build up below the cooling pit crater floor. Magmatic foams are extruded to form Type 1 IMP deposits. Type 2 IMPs on the flanks are interpreted to be due primarily to subsequent impacts causing collapse of the flow surface layer into the extremely vesicle‐ and void‐rich flow interior. Anomalously young pit crater floor/shield flank crater retention ages compared with surrounding maria ages may be due to effects of Cauchy 5 substrate characteristics (extreme micro‐ and macroporosity, foamy nature, and glassy auto‐regolith) on superposed crater formation and retention.
Simulating the Reiner Gamma Swirl: The Long‐Term Effect of Solar Wind Standoff
Authors: Deca J. , Hemingway D. J. , Divin A. , Lue C. , Poppe A. R. , Garrick‐Bethell I. , Lembège B. , Horányi M. 
Published: February 2020

AbstractThe Reiner Gamma swirl is a prime location to investigate the lunar albedo patterns and their colocation with magnetic anomalies. The precise relationship between impinging plasma and the swirl, and, in particular, how these interactions vary over the course of a lunar day, remains an open issue. Here we use a fully kinetic particle‐in‐cell code, coupled with a magnetic field model based on orbital‐altitude observations, and simulate the interaction with the Reiner Gamma anomaly for all plasma regimes the region is exposed to along a typical orbit, including different solar wind incidence angles and the Moon's crossing through the terrestrial magnetosphere. Consistent with the hypothesis that swirls form as a result of plasma interactions with near‐surface magnetic fields, we show that the energy flux profile produces a pattern similar to Reiner Gamma's alternating bright and darkly colored bands, but only when integrating over the full lunar orbit. We additionally show that including He
as a self‐consistent plasma species improves the match.
Mare Deposits Identification and Feature Analysis in Mare Australe Based on CE‐2 CELMS Data
Authors: Meng Z.G. , Chen S.B. , Zheng Y.C. , Cheng W.M. , Zhu Y.Q. , Cai Z.C. , Zhang Y.Z. , Cao W. , Hou L.L. 
Published: February 2020

AbstractThe microwave signal has the penetration capability, which provides a potential chance to improve understanding of the mare deposits and the formation process of Mare Australe, a complex, extensive, and poorly understood region on the Moon. In this paper, the Chang'E‐2 microwave radiometer (CELMS) data were selected and processed to evaluate the microwave thermal emission features of the mare deposits in Mare Australe. After comparison, the dTB map at 3.0 GHz is employed. The results are as follows. (a) The possible cryptomare is much more extensive in Australe region than that identified with optical data. (b) The basaltic volcanism is re‐understood as three major episodes. (c) The high dTB anomaly is interpreted as the location of the vent areas in the mare patches. (d) The K‐means algorithm was first used to process the CELMS data, and the identified linear and ring structures indicate some important information about the formation processes of Mare Australe. These special findings will be of fundamental significance to better understand the basaltic volcanism and the evolution of the lunar surface.
Seasonal Subsurface Thaw Dynamics of an Aufeis Feature Inferred From Geophysical Methods
Authors: Terry Neil , Grunewald Elliot , Briggs Martin , Gooseff Michael , Huryn Alexander D. , Kass M. Andy , Tape Ken D. , Hendrickson Patrick , Lane John W. 
Published: February 2020

AbstractAufeis are sheets of ice unique to cold regions that originate from repeated flooding and freezing events during the winter. They have hydrological importance associated with summer flows and winter insulation, but little is known about the seasonal dynamics of the unfrozen sediment layer beneath them. This layer may support perennial groundwater flow in regions with otherwise continuous permafrost. For this study, ground penetrating radar (GPR) were collected in September 2016 (maximum thaw) and April 2017 (maximum frozen) at the Kuparuk aufeis field on the North Slope of Alaska. Supporting surface nuclear magnetic resonance data were collected during the maximum frozen campaign. These point‐in‐time geophysical data sets were augmented by continuous subsurface temperature data and periodic Structure‐from‐Motion digital elevation models collected seasonally. GPR and difference digital elevation model data showed up to 6 m of ice over the sediment surface. Below the ice, GPR and nuclear magnetic resonance identified regions of permafrost and regions of seasonally frozen sediment (i.e., the active layer) underlain by a substantial lateral talik that reached >13‐m thickness. The seasonally frozen cobble layer above the talik was typically 3‐ to 5‐m thick, with freezing apparently enabled by relatively high thermal diffusivity of the overlying ice and rock cobbles. The large talik suggests that year‐round groundwater flow and coupled heat transport occurs beneath much of the feature. Highly permeable alluvial material and discrete zones of apparent groundwater upwelling indicated by geophysical and ground temperature data allows direct connection between the aufeis and the talik below.
Simple-to-use nomogram for evaluating the incident risk of moderate-to-severe LEAD in adults with type 2 diabetes: A cross-sectional study in a Chinese population
Authors: Zhao Xin , Zhang Xiaomei , Ran Xingwu , Xu Zhangrong , Ji Linong 
Published: February 2020

AbstractThis study aimed to analyze the clinical characteristics of lower extremity atherosclerotic disease (LEAD) in Chinese adult type 2 diabetes (T2D) patients, and also explored the risk factors for LEAD and developed simple-to-use nomograms for LEAD and lesion degree in these patients. We retrospectively studied 4422 patients (male = 2084; female = 2338) with T2D who were ≥50. Based on lower extremity arterial ultrasound findings, we divided the patients into three groups: normal, mild, and moderate-to-severe group. The factors related to LEAD in patients with T2D were analyzed by logistic regression analysis. The risk factors for moderate-to-severe LEAD included: high HbA1c (OR = 1.07 95% CI 1.02–1.13), diabetic peripheral neuropathy (OR = 1.93 95% CI 1.57–2.37), and diabetic retinopathy (OR = 1.26 95%CI 1.01–1.57). The overall areas under the receiver operating characteristic curves for the nomograms for predicting the risks of LEAD and moderate-to-severe LEAD in adult T2D patients were 0.793 (95%CI 0.720, 0.824) and 0.736 (95%CI 0.678, 0.795), respectively. The developed nomograms are simple to use and enable preliminary visual prediction of the risk and degree of LEAD in Chinese T2D patients over 50 years. The nomograms are accurate to a certain degree and provide a clinical basis for predicting the occurrence and progression of LEAD.
Improved Gait Parameters After Orthotic Treatment in Children with Infantile Tibia Vara
Authors: Alsancak Serap , Guner Senem , Kınık Hakan 
Published: February 2020

AbstractThe aim of this study was to investigate the modification of gait kinematics before and after orthotic treatment in patients with ITV. Vicon instrumented gait analysis was performed on three patients with ITV, pre and post treatment. Orthoses were applied a total of eighteen participants with ITV who were 25–38 months. 34 extremities were treated and radiographic evidence evaluated before and after orthotic treatment. Treatment duration for orthotic treatment ranged between 11 and 41 (25.9 ± 10.0) months. Only three patients were evaluated in gait analysis due to application difficulties. Three patients kinematic and kinetic instrumented gait analysis were found flatfoot, varus and internal rotation of the foot, hip flexion and external rotation. Study were reported an improvement in gait kinematics after orthotic treatment, in patients with ITV.
Extending the Spectrum of Dysgraphia: A Data Driven Strategy to Estimate Handwriting Quality
Authors: Asselborn Thibault , Chapatte Mateo , Dillenbourg Pierre 
Published: February 2020

AbstractThis paper proposes new ways to assess handwriting, a critical skill in any child’s school journey. Traditionally, a pen and paper test called the BHK test (Concise Evaluation Scale for Children’s Handwriting) is used to assess children’s handwriting in French-speaking countries. Any child with a BHK score above a certain threshold is diagnosed as ‘dysgraphic’, meaning that they are then eligible for financial coverage for therapeutic support. We previously developed a version of the BHK for tablet computers which provides rich data on the dynamics of writing (acceleration, pressure, and so forth). The underlying model was trained on dysgraphic and non-dysgraphic children. In this contribution, we deviate from the original BHK for three reasons. First, in this instance, we are interested not in a binary output but rather a scale of handwriting difficulties, from the lightest cases to the most severe. Therefore, we wish to compute how far a child’s score is from the average score of children of the same age and gender. Second, our model analyses dynamic features that are not accessible on paper; hence, the BHK is useful in this instance. Using the PCA (Principal Component Analysis) reduced the set of 53 handwriting features to three dimensions that are independent of the BHK. Nonetheless, we double-checked that, when clustering our data set along any of these three axes, we accurately detected dysgraphic children. Third, dysgraphia is an umbrella concept that embraces a broad variety of handwriting difficulties. Two children with the same global score can have totally different types of handwriting difficulties. For instance, one child could apply uneven pen pressure while another one could have trouble controlling their writing speed. Our new test not only provides a global score, but it also includes four specific score for kinematics, pressure, pen tilt and static features (letter shape). Replacing a global score with a more detailed profile enables the selection of remediation games that are very specific to each profile.
Specific memory B cell response in humans upon infection with highly pathogenic H7N7 avian influenza virus
Authors: Westerhuis Brenda , ten Hulscher Hinke , Jacobi Ronald , van Beek Josine , Koopmans Marion , Rimmelzwaan Guus , Meijer Adam , van Binnendijk Rob 
Published: February 2020

AbstractH7 avian influenza viruses represent a major public health concern, and worldwide outbreaks raise the risk of a potential pandemic. Understanding the memory B cell response to avian (H7) influenza virus infection in humans could provide insights in the potential key to human infection risks. We investigated an epizootic of the highly pathogenic A(H7N7) in the Netherlands, which in 2003 led to infection of 89 persons and one fatal case. Subtype-specificity of antibodies were determined for confirmed H7N7 infected individuals (cases) (n = 19), contacts of these cases (n = 21) and a comparison group controls (n = 16), by microarray, using recombinant hemagglutinin (HA)1 proteins. The frequency and specificity of memory B cells was determined by detecting subtype-specific antibodies in the culture supernatants from in vitro stimulated oligoclonal B cell cultures, from peripheral blood of cases and controls. All cases (100%) had high antibody titers specific for A(H7N7)2003 (GMT > 100), whereas H7-HA1 antigen binding was detected in 29% of contacts and 31% of controls, suggesting that some of the H7 reactivity stems from cross reactive antibodies. To unravel homotypic and heterotypic responses, the frequency and specificity of memory B cells were determined in 2 cases. Ten of 123 HA1 reactive clones isolated from the cases bound to only H7- HA1, whereas 5 bound both H7 and other HA1 antigens. We recovered at least four different epitopal reactivities, though none of the H7 reactive antibodies were able to neutralize H7 infections in vitro. Our study serologically confirms the infection with H7 avian influenza viruses, and shows that H7 infection triggers a mixture of strain -specific and cross-reactive antibodies.
Optically tunable terahertz chiral metasurface based on multi-layered graphene
Authors: Masyukov Maxim , Vozianova Anna , Grebenchukov Alexander , Gubaidullina Kseniya , Zaitsev Anton , Khodzitsky Mikhail 
Published: February 2020

AbstractActive manipulation of the polarization states at terahertz frequencies is crucially helpful for polarization-sensitive spectroscopy, having significant applications such as non-contact Hall measurements, vibrational circular dichroism measurements and anisotropy imaging. The weakness of polarization manipulation provided by natural materials can be overcomed by chiral metamaterials. Chiral metamaterials have a huge potential to achieve the necessary polarization effects, hence they provide the basis for applications such as ultracompact polarization components. Terahertz chiral metamaterials that allow dynamic polarization modulation of terahertz waves are of great practical interest and still challenging. Here, we show that terahertz metasurface based on the four conjugated “petal” resonators integrated with multi-layered graphene (MLG) can enable dynamically tunable chiroptical response using optical pumping. In particular, a change of ellipticity angle of 20° is observed around 0.76 THz under optical pumping by a 980 nm continuous wave (CW) laser. Furthermore, using temporal coupled-mode theory, our study also reveals that the chiroptical response of the proposed multi-layered graphene-based metasurface is strongly dependent on the influence of optical pumping on the loss parameters of resonance modes, leading to actively controllable polarization states of the transmitted terahertz waves. The present work paves the way for the realization of fundamental terahertz components capable for active polarization manipulation.
Association between Dietary Quality and Prediabetes based on the Diet Balance Index
Authors: He Dingliu , Qiao Yanan , Xiong Suting , Liu Siyuan , Ke Chaofu , Shen Yueping 
Published: February 2020

AbstractDietary quality is an important factor influencing prediabetes, but few studies have applied the Chinese Diet Balance Index (DBI-16) to evaluate the dietary quality of individuals with prediabetes and explore the associations between dietary quality and prediabetes. In our study, the lower-bound score, higher-bound score and diet quality distance, were respectively calculated to assess dietary quality based on each food group. Logistic regression was used to calculate the odds ratio (OR) and 95% confidence interval (95%CI) of unfavorable dietary quality leading to prediabetes in every subgroup. The results were shown that individuals with prediabetes had excessive intake in the categories of cereals, salt and inadequate intake in vegetables, fish and diet variety than participants without prediabetes (all P < 0.01). Unfavourable dietary quality was significantly associated with an increased risk of prediabetes (OR: 1.45, 95%CI: 1.29–1.63), especially among the subjects who lived in rural areas (OR: 1.63, 95%CI: 1.25–1.76), those who had abdominal obesity (OR: 1.58, 95%CI: 1.36–1.85), those who smoked (OR: 1.58, 95%CI: 1.30–1.93), those who consumed alcohol (OR: 1.57, 95%CI: 1.28–1.93) and those who did not drink tea (OR: 1.64, 95%CI: 1.42–1.88). In Conclusion, unfavourable dietary quality was significantly associated with an increased risk of prediabetes.
T-13 and T-26, the novel taxanes with improved oral bioavailability in rats
Authors: Jing Yun-Rong , Zhou Wei , Wang Xiang-Yang 
Published: February 2020

AbstractIn an attempt to improve the oral bioavailability of taxanes, a series of new analogues were synthesized and tested in a panel of human tumor cell lines and cellular permeability assays. Compounds T-13 and T-26 showed potent cytotoxicity and exhibited the highest permeability, so they were selected for pharmacokinetic studies. Here, pharmacokinetics of T-13 and T-26 were studied after intravenous injection (5 mg/kg) and oral administration (60 mg/kg) in male Sprague-Dawley (S.D.) rats, respectively. Plasma concentrations were characterized using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The oral bioavailability of T-13 and T-26 was determined to be 10.71% and 65.79%, respectively. Compounds T-13 and T-26 were both poor substrates of P-glycoprotein (P-gp), and they had a much higher bioavailability than paclitaxel, especially T-26. T-26 with good oral bioavailability represented a potential candidate for potent antitumor activity given oral administration.
Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns
Authors: Ma Duo , Bronk Lawrence , Kerr Matthew , Sobieski Mary , Chen Mei , Geng Changran , Yiu Joycelyn , Wang Xiaochun , Sahoo Narayan , Cao Wenhua , Zhang Xiaodong , Stephan Clifford , Mohan Radhe , Grosshans David R. , Guan Fada 
Published: February 2020

AbstractIn current treatment plans of intensity-modulated proton therapy, high-energy beams are usually assigned larger weights than low-energy beams. Using this form of beam delivery strategy cannot effectively use the biological advantages of low-energy and high-linear energy transfer (LET) protons present within the Bragg peak. However, the planning optimizer can be adjusted to alter the intensity of each beamlet, thus maintaining an identical target dose while increasing the weights of low-energy beams to elevate the LET therein. The objective of this study was to experimentally validate the enhanced biological effects using a novel beam delivery strategy with elevated LET. We used Monte Carlo and optimization algorithms to generate two different intensity-modulation patterns, namely to form a downslope and a flat dose field in the target. We spatially mapped the biological effects using high-content automated assays by employing an upgraded biophysical system with improved accuracy and precision of collected data. In vitro results in cancer cells show that using two opposed downslope fields results in a more biologically effective dose, which may have the clinical potential to increase the therapeutic index of proton therapy.
Investigating cone photoreceptor development using patient-derived NRL null retinal organoids
Authors: Kallman Alyssa , Capowski Elizabeth E. , Wang Jie , Kaushik Aniruddha M. , Jansen Alex D. , Edwards Kimberly L. , Chen Liben , Berlinicke Cynthia A. , Joseph Phillips M. , Pierce Eric A. , Qian Jiang , Wang Tza-Huei , Gamm David M. , Zack Donald J. 
Published: February 2020

AbstractPhotoreceptor loss is a leading cause of blindness, but mechanisms underlying photoreceptor degeneration are not well understood. Treatment strategies would benefit from improved understanding of gene-expression patterns directing photoreceptor development, as many genes are implicated in both development and degeneration. Neural retina leucine zipper (NRL) is critical for rod photoreceptor genesis and degeneration, with NRL mutations known to cause enhanced S-cone syndrome and retinitis pigmentosa. While murine Nrl loss has been characterized, studies of human NRL can identify important insights for human retinal development and disease. We utilized iPSC organoid models of retinal development to molecularly define developmental alterations in a human model of NRL loss. Consistent with the function of NRL in rod fate specification, human retinal organoids lacking NRL develop S-opsin dominant photoreceptor populations. We report generation of two distinct S-opsin expressing populations in NRL null retinal organoids and identify MEF2C as a candidate regulator of cone development.