bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENYUSUNAN TINDAKAN PERBAIKAN SISTEM PENGENDALIAN INTERNAL PIUTANG PADA KOPERASI SIMPAN PINJAM (KSP) JRX
Authors: Fitria Warda , Zulpi Agha Ridwan 
Published: December 2024

Koperasi Simpan Pinjam (KSP) JRX yang bergerak di bidang usaha pengkreditan atau pemberian pinjaman kepada anggotanya, untuk memberikan pinjaman bagi calon debitur, salah satu risiko yang menyebabkan adalah piutang berupa piutang tak tertagih. Penelitian ini bertujuan untuk menganalisis kesenjangan pengendalian yang ada pada sistem pengendalian internal piutang Koperasi Simpan Pinjam JRX dan menyusun rekomendasi tindakan perbaikan atas kesenjangan pengendalian, serta mengimplementasikan sistem pengendalian internal piutang pada Koperasi Simpan Pinjam JRX. Jenis penelitian ini adalah penelitian kualitatif deskriptif. Sumber data dalam penelitian ini adalah data primer. Metode pengumpulan data yang digunakan adalah melalui proses dokumentasi, wawancara dan observasi. Hasil penelitian ini menunjukkan bahwa penerapan sistem pengendalian intern piutang pada komponen lingkungan pengendalian, penilaian risiko, aktivitas pengendalian, informasi dan komunikasi, dan kegiatan pemantauan telah berjalan cukup efektif. pada setiap komponen tersebut terdapat kesenjangan pengendalian yang telah teridentifikasi yang mengakibatkan munculnya kerugian piutang. Beberapa rekomendasi tindakan perbaikan diberikan kepada pihak koperasi agar koperasi dapat memperbaiki dan meningkatkan sistem pengendalian internal pada bagian piutang.
Kata kunci: Piutang, Sistem Pengendalian Internal, Celah Pengendalian
Synchronous and anti-phase drumming elicit similar prosocial behavior ratings
Authors: McWeeny Sean , Luoma Adam C. , Al-Saleem Yaseen , Trainor Laurel J. 
Published: December 2024

PurposeMusic performance facilitates prosociality across many cultures and contexts. Interestingly, the relationship between prosociality and sensorimotor synchronization (SMS) has so far primarily been demonstrated in the context of in-phase synchrony with only a few mixed results for anti-phase coordination. In anti-phase coordination, participants move at the same rate, at opposite phases, which also requires high levels of coordination and attention. This case is particularly relevant for music and prosociality, as music regularly involves naturalistic anti-phase coordination. We thus tested whether anti-phase synchronization is as effective as in-phase synchronization at eliciting prosocial behavior.MethodsDyads (N = 50 dyads) were randomly assigned to complete four trials of a drumming sensorimotor synchronization-continuation task (SCT) either alone, synchronously or in anti-phase. Before and after the drumming task, dyads completed a behavioral economics game involving trust. Additionally, a questionnaire about trust, cooperation, affect, and similarity was given after the drumming task.ResultsCooperation rates in the stag-hunt game were near ceiling (~87%) across all conditions pre-SCT, with negligible change after the drumming task. Questionnaire items were analyzed using Bayesian probit mixed effects models to account for dyadic sampling and ordinal data, and to provide evidence in favor of the null hypothesis. Models provided moderate to extremely strong evidence that the anti-phase and in-phase coordination conditions rated their affect, trust, similarity, and cooperation more strongly than dyads in the alone condition (all BF10 &gt; 3). When only comparing the anti-phase and in-phase conditions, moderate evidence in favor of the null (i.e., that phase does not affect ratings) was found for all questions (all BF10 &lt; 0.3). Descriptions of the posterior, as well as leave-one-out cross validation (LOO) results, were in general accordance with the Bayes Factor results.ConclusionEvidence indicates anti-phase drumming coordination is as effective as in-phase in increasing perceived trust, cooperation, affect, and similarity. Future analyses will examine how other characteristics of the drumming coordination, such as the lag-1 autocorrelation and variability of the inter-tap interval time-series, relate to prosocial behavior and ratings of trust and cooperation.
Surveillance of Vibrio cholerae serogroups (O1 and O139) from surface and ground water sources in the Vhembe district, Limpopo province, South Africa
Authors: Kachienga Leonard , Rikhotso Mpumelelo Casper , Traore Afsatou Ndama , Potgieter Natasha 
Published: December 2024

IntroductionVibrio cholera is increasingly emerging as a significant public health concern in developing countries. Choleragenic Vibrio cholerae O1 and O139 has reported to cause devastating disease and economic burdens in developing countries. In rural areas of the Vhembe district, most rivers and several communal boreholes are polluted as a result of sanitation issues around these water sources. The aim of this study was to determine the presence of choleragenic V. cholerae O1 and O139 in rivers and communal boreholes.MethodsThe analysis of physicochemical parameters and molecular techniques was used to establish the adaptation and detect the serogroups of V. cholerae in the water samples.Results and DiscussionThe results reported that electrical conductivities (EC) ranged between 18.78 and 154 μS/cm, with rivers such as Madandze and Mvudi recording &gt;80 μS/cm, and those of the communal boreholes were ranged between 23.4 and 295 μS/cm, which were above the acceptable South African water quality guidelines of 0–70 μS/cm for rivers and communal boreholes. The results further revealed that most of the rivers detected positive for V. cholerae, except for the Mukhase river; the downstream points of Livuvhu and Nwedi rivers and the upstream point of the Nzhelele river; and several of the communal boreholes (Mak B1, B2, Kwe B3, 4, and 6) also tested positive for the presence of V. cholerae. The toxigenic Vibrios was also reported in Mutshundudi, Tshinane rivers, the upstream of Dzindi, Madanzhe, Nwedi, and the downstream of Sambandou rivers, as well as Mak B1, B2, and Kwe3 of communal boreholes. The serogroup O1 was detected on the Mutshundudi and Tshinane rivers, while serogroup O139 was detected upstream of the Dzindi, Madanzhe, Mutshundudi, and Tshinane rivers. There was also detection of the O1 serogroup in the communal boreholes (Mak B1 and Kwe B3), while O139 was only detected in one communal borehole (Mak B2). The development of robust policies, including an integrated water and sanitation safety surveillance web tool for monitoring water resources and public health protection, is required to make sure that drinking water in rural communities is safe for consumption.
The frequent variant A57F in the GNE gene in patients from Russia has Finno-Ugric Mari origin
Authors: Subbotin Dmitrii , Ionova Sofya , Marakhonov Andrey , Saifullina Elena , Borovikov Artem , Akhmadeeva Leila , Chausova Polina , Ryzhkova Oksana , Zinchenko Rena , Kutsev Sergey , Murtazina Aysylu 
Published: December 2024

IntroductionGNE-myopathy is a distal myopathy with adult-onset and initial involvement of anterior leg compartment. A founder effect has been demonstrated for some patients from several large cohorts in different countries.MethodsIn this study, we investigated the allele frequency of the c.169_170delinsTT (p.(Ala57Phe)) variant in the GNE gene (NM_001128227.3) among different ethnic populations (Mari, Tatar, and Bashkir) and estimated the age of the mutation’s spread event.ResultsThe c.169_170delinsTT variant in the GNE gene was detected in the Mari population with an allele frequency of 0.003788 but was not found in the Tatar or Bashkir populations. The disease incidence is estimated to be 1.43 (95% CI: 0.00092–43.78) per 100,000 in the Mari population. According to our study, the estimated age of the mutation’s spread is 160.46 years (95% CI: 45.55–244.14).DiscussionBy comparing the information gathered with historical data on migration patterns in the Middle Volga region and estimating the age of the variant’s dissemination, we propose hypotheses regarding its origin and the pathways through which it spread. In the current context of increased rate of interethnic marriages, investigating the spread of common pathogenic variants from historically isolated populations is important for molecular genetic diagnosis. This approach aids in optimizing diagnostic processes and reducing the diagnostic odyssey for patients.
Intelligent vehicle obstacle avoidance strategy application supported by fuzzy control theory
Authors: Wang Qianqian , He Shaolin , Zhao Zhu 
Published: December 2024

IntroductionWith the continuous progress of the automotive industry, the safe driving of intelligent vehicles has received increasing attention. Traditional obstacle avoidance techniques are not accurate enough in dealing with fuzzy information encountered in high-speed driving. Therefore, this study aims to improve the obstacle avoidance ability of intelligent vehicles through fuzzy control theory.MethodsThe study employs fuzzy control theory to enhance the ability of intelligent vehicles to process fuzzy information, thereby improving conventional obstacle avoidance techniques. A combination of visual sensing and ultrasonic detection equipment was used to comprehensively plan the real-time obstacle avoidance routes of the intelligent vehicle.Results and DiscussionThe improved obstacle avoidance technique achieves an accuracy of 96.11%, which is better than the comparison avoidance technique. In the absence of interfering signals, the running time and overshoot were 2.4 s and 7%, respectively, again superior to the comparison technique. The experimental results show that the obstacle avoidance technique proposed in this study can improve the recognition ability of intelligent vehicles on fuzzy information, so as to improve the accuracy of obstacle recognition and provide certain guarantee for the safe driving of intelligent vehicles.
Dynamic survival prediction of end-stage kidney disease using random survival forests for competing risk analysis
Authors: Christiadi Daniel , Chai Kevin , Chuah Aaron , Loong Bronwyn , Andrews Thomas D. , Chakera Aron , Walters Giles Desmond , Jiang Simon Hee-Tang 
Published: December 2024

Background and hypothesisA static predictive model relying solely on baseline clinicopathological data cannot capture the heterogeneity in predictor trajectories observed in the progression of chronic kidney disease (CKD). To address this, we developed and validated a dynamic survival prediction model using longitudinal clinicopathological data to predict end-stage kidney disease (ESKD), with death as a competing risk.MethodsWe trained a sequence of random survival forests using a landmarking approach and optimized the model with a pre-specified prediction horizon of 5 years. The predicted cumulative incidence function (CIF) values were used to generate a personalized dynamic prediction plot.ResultsThe model was developed using baseline demographics and 13 longitudinal clinicopathological variables from 4,950 patients. Variable importance analysis for ESKD and death informed the creation of a sequence of reduced models that utilized six key variables: age, serum albumin, bicarbonate, chloride, eGFR, and hemoglobin. The models demonstrated robust predictive performance, with a median concordance index of 84.84% for ESKD and 84.1% for death. The median integrated Brier scores were 0.03 for ESKD and 0.038 for death across all landmark times. External validation with 8,729 patients confirmed these results.ConclusionWe successfully developed and validated a dynamic survival prediction model using common longitudinal clinicopathological data. This model predicts ESKD with death as a competing risk and aims to assist clinicians in dialysis planning for patients with CKD.
Genetic diversity and distinction of Enterococcus faecium and Enterococcus lactis in traditional Montenegrin brine cheeses and salamis
Authors: Daza Prieto Beatriz , Raicevic Nadja , Martinovic Aleksandra , Ladstätter Johann , Zuber Bogdanovic Ivana , Schorpp Anika , Stoeger Anna , Mach Robert L. , Ruppitsch Werner , Cabal Adriana 
Published: December 2024

IntroductionEnterococcus faecium is a widespread acid-lactic bacterium found in the environment, humans, and animal microbiota, and it also plays a role in the production of traditional food. However, the worldwide emergence of multidrug-resistant E. faecium strains represents a major public health threat and is the primary reason that the genus Enterococcus is not recommended for the Qualified Presumption of Safety (QPS) list of the European Food Safety Authority (EFSA), raising concerns about its presence in food products.MethodsIn this study, 39 E. faecium and 5 E. lactis isolates were obtained from artisanal brine cheeses and dry sausages, sourced from 21 different Montenegrin producers. The isolates were collected following the ISO 15214:1998 international method and processed for whole-genome sequencing (WGS).ResultsGenome analysis based on core genome multilocus sequence type (cgMLST) revealed a high diversity among isolates. Furthermore, the isolates carried antimicrobial resistance genes; the virulence genes acm, sgrA, and ecbA; the bacteriocin genes Enterolysin A, Enterocin A, Enterocin P, Duracin Q, Enterocin B, Bacteriocin 31, Enterocin EJ97, Sactipeptides, and Enterocin SEK4; the secondary metabolite genes T3PKS, cyclic lactone autoinducer, RiPP-like, and NRPS and a maximum of eight plasmids.ConclusionThis study highlights the need for careful monitoring of E. faecium and E. lactis strains in food to ensure they do not pose any potential risks to consumer safety.
Kaempferol restores the susceptibility of ESBLs Escherichia coli to Ceftiofur
Authors: Li Peng-Cheng , Tong Yin-Chao , Xiao Xing-Lan , Fan Yun-Peng , Ma Wu-Ren , Liu Ying-Qiu , Zhuang Shen , Qing Su-Zhu , Zhang Wei-Min 
Published: December 2024

IntroductionThe development of extended-spectrum-beta-lactamase (ESBLs) Escherichia coli (E. coli) has become a global threat to public health. An alternative strategy to alleviate this is identifying potential natural compounds to restore antibiotic activity against ESBLs E. coli. This study aimed to find a possible compound to restore ESBLs E. coli sensitivity to ceftiofur.MethodsThe synergistic effect of kaempferol and ceftiofur against ESBLs E. coli was investigated by checkerboard assays, time-kill, growth curves, and scanning electronic microscope. The impact of kaempferol with ceftiofur on the biofilm of ESBLs E. coli was evaluated by crystal violet staining and laser scanning confocal microscopy and this study also assessed the effect of kaempferol on the initial adhesion and aggregation of E. coli (SY20) by examining motility, adhesion, and surface characteristics. The RT-qPCR was used to determine the effect of kaempferol on the expression of genes related to the LuxS/AI-2 quorum sensing system in ESBLs E. coli, and the effect of kaempferol on AI-2 signaling molecules was determined by molecular docking and bioassay. The impact of kaempferol on the activity of blaCTX-M-27 protein was determined by RT-qPCR, molecular docking, and nitrofen experiments, the results were further verified by transcriptome analysis. The mouse infection model was established, and the inhibitory mechanism of kaempferol with ceftiofur on bacteria in vivo was further verified by HE staining and immunohistochemistry.Results and discussionKaempferol with ceftiofur exerts synergistic antibacterial and bactericidal effects on ESBLs E. coli by influencing β-lactamase activity, biofilm formation, and LuxS/AI-2 QS system. In vivo, kaempferol protected the small intestinal villi from the damage of ESBLs E. coli. Furthermore, kaempferol fully restores the activity of ceftiofur in animal infection models by relieving the TLR4/NF-κb pathway. In conclusion, the sensitivity of ESBLs E. coli to ceftiofur in vitro and in vivo could be enhanced by kaempferol, which showed that kaempferol may be a kind of antibiotic adjuvant.
Multi-omics analysis reveals interactions between host and microbes in Bama miniature pigs during weaning
Authors: Ma Wen , Yin Li , Hu Ying , Liu Xu , Guo Zhenghong , Zhong Bingyang , Qiu Haofeng , Li Jing 
Published: December 2024

IntroductionThere are complex interactions between host and gut microbes during weaning, many of the mechanisms are not yet fully understood. Previous research mainly focuses on commercial pigs, whereas limited information has been known about the host and gut microbe interactions in miniature pigs.MethodsTo address the issue in Bama miniature piglets that were weaned 30 days after birth, we collected samples on days 25 and 36 for metabolomics, transcriptomics, and microgenomics analysis.Results and discussionThe average daily weight gain of piglets during weaning was only 58.1% and 40.6% of that during 0-25 days and 36-60 days. Metabolomic results identified 61 significantly different metabolites (SDMs), of which, the most significantly increased and decreased SDMs after weaning were ectoine and taurocholate, respectively, indicating the occurrence of inflammation. Metagenomic analysis identified 30 significantly different microbes before and after weaning. Bacteria related to decreasing intestinal inflammation, such as Megasphaera, Alistipes and Bifidobacterium, were enriched before weaning. While bacteria related to infection such as Chlamydia, Clostridium, Clostridioides, and Blautia were enriched after weaning. The carbohydrate enzymes CBM91, CBM13, GH51_1, and GH94 increase after weaning, which may contribute to the digestion of complex plant fibers. Furthermore, we found the composition of antibiotic resistance genes (ARGs) changed during weaning. Transcriptomic analysis identified 147 significantly differentially expressed genes (DEGs). The upregulated genes after weaning were enriched in immune response categories, whereas downregulated genes were enriched in protein degradation. Combining multi-omics data, we identified significant positive correlations between gene MZB1, genera Alistipes and metabolite stachydrine, which involve anti-inflammatory functions. The reduced abundance of bacteria Dialister after weaning had strong correlations with the decreased 2-AGPE metabolite and the downregulated expression of RHBDF1 gene. Altogether, the multi-omics study reflects dietary changes and gut inflammation during weaning, highlighting complex interactions between gut microbes, host genes and metabolites.”
Postural imbalance without visual input is associated with specific neuropsychological deficits in older adults – results from the LIFE-adult study
Authors: Grill Eva , Zwergal Andreas , Saur Dorothee , Klingbeil Julian , Fricke Christopher , Schöberl Florian , Felfela Karim , Zülke Andrea , Riedel-Heller Steffi , Classen Joseph 
Published: December 2024

IntroductionModifiable risk factors play an important role in preventing dementia and reducing its progression. Regular physical activity already in midlife, which relies on intact multisensory balance control, can help to decrease the risk of dementia. However, our understanding of the relationship between postural balance and cognitive functions remains limited. The objective of our study was to investigate the association of postural balance during different sensory conditions with specific cognitive domains in older adults.MethodsParticipants were from the population-based prospective “Leipzig Research Center for Civilization Diseases” (LIFE-Adult) cohort in Leipzig, Germany. Executive, memory and processing speed functions were tested by the Consortium to Establish a Registry for Alzheimer’s disease (CERAD) plus battery. Assessment of visuospatial abilities was based on the short form of the Judgment of Line Orientation Test (JLO). Postural sway was recorded on a force plate with eyes open and closed. Romberg’s ratios were calculated for sway path and sway area as a proxy for balance without visual control and tested in generalized linear regression models with the summary scores of executive function, memory, processing speed and visuospatial function as dependent variables. All models were adjusted for sex, age, ApoE status, socioeconomic status, anamnestic stroke, and diabetes.ResultsIn total, we analyzed 460 participants with a mean age of 68.6 years, range 60 to 80, 47.6% female. A higher Romberg’s ratio for sway area was a significant indicator for impaired visuospatial abilities as measured by the dichotomized JLO (Odds Ratio = 1.42, 95% confidence interval 1.07 to 1.88). Romberg’s ratios were not significantly associated with executive functions, procedural speed or memory functions.DiscussionIt may be worthwhile to examine in the future whether inclusion of balance testing enhances the value of screening programs for cognitive impairment. Inversely, it may be appropriate to apply routine cognitive tests when balance problems are detected in older patients.
Preoperative diagnosis of primary ovarian lymphoma: a case report and a decade of insights
Authors: Liu Wei , Xu Houyun , Hu Jibo , Yu Xiping , Zhou Junjie , Hu Hongjie 
Published: December 2024

Through a comprehensive retrospective analysis of a 52-year-old woman with primary ovarian lymphoma (POL) and a review of similar cases over the past decade in the PubMed database, we gained several key insights into improving the understanding of POL among clinicians and radiologists for accurate diagnosis. POL is more prevalent among women in their 40s and usually presents with clinical manifestations of a solid mass (typically over 10 cm) and abdominal pain with B symptoms. Four imaging features show promise as indicators of potential diagnostic value in POL: the ovarian retention sign, touching ovaries, vascular floatation, and the sandwich sign. More than half of primary ovarian diffuse large B-cell lymphoma (DLBCL) cases have elevated lactate dehydrogenase (LDH) or carbohydrate antigen 125 (CA-125) levels. This comprehensive understanding of POL suggests that the combination of these four imaging features with elevated levels of CA-125 and LDH might help in the diagnosis of POL preoperatively, preventing unnecessary surgical interventions.
Infectious keratitis in Western New York: a 10-year review of patient demographics, clinical management, and treatment failure
Authors: Maretz Caroline , Atlas Jason , Shah Shalini , Sohn Michael B. , Wozniak Rachel A. F. 
Published: December 2024

BackgroundInfectious keratitis (IK) is a blinding disease and an important cause of ocular morbidity. Understanding regional trends in IK are important to understand the epidemiology and clinical outcomes of this disease.MethodsIn this 10-year retrospective review, patient characteristics including sociodemographic factors, medical history, and ocular history were collected as well as the clinical course and outcomes. This study particularly focused on these characteristics as it relates to treatment failure in IK, as defined as requiring more than 2 weeks to heal or surgical intervention, likelihood of having microbiology cultures collected, surgical intervention, and presenting disease severity.Results935 cases of IK were identified at the University of Rochester. Age (p=0.004), history of prior corneal transplant (p=0.009), severe vision loss on presentation (p&lt;0.001), large ulcer size (p=0.001), and fungal (p=0.001) or protozoan (p=0.009) infections were all significantly associated with treatment failure. Both ulcer size (p&lt;0.001) and severity of vision loss (p&lt;0.001) were associated with a higher likelihood of having microbiology cultures as well as surgical intervention. Patients’ whose home address was greater than 60 miles from the University were also more likely to present with a more severe ulcer (p&lt;0.001) and undergo a surgical intervention (p=0.05). In studying the impact of race and ethnicity, Black patients were less likely to receive corneal cultures compared to White patients (p=0.02).ConclusionsThis study defined the patient characteristics and clinical course of patients with IK over 10 years at the University of Rochester providing insight into regional trends of the patient population as well as clinical outcomes.