bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple Autoimmune Syndrome: An Unusual Combination of Autoimmune Disorders
Authors: Sarfaraz Sabahat , Anis Sabiha 
Published: June 2020

Background:
Autoimmune diseases are multifactorial with environmental and heritable
factors. Autoimmunity reflects an altered immune status, therefore the presence of more than one
disorder is not uncommon. The coexistence of three or more autoimmune diseases in a patient constitutes
multiple autoimmune syndrome (MAS). This is an interesting case of a middle-aged female
who had celiac disease, primary biliary cholangitis, autoimmune hepatitis and evolving CREST
(Calcinosis, Rhaynaud’s phenomenon, Esophageal dysmotility, Sclerodactyly and Telangiectasia)
syndrome.

Case Report:
Fifty years old female patient presented with generalized fatigue, fever, weight loss,
vertigo and constipation. She was a diagnosed case of celiac disease, and responded well to glutenfree
diet. Family history was unremarkable for any autoimmune disorder. Laboratory workup
showed normal complete blood counts, markedly elevated transaminases and alkaline phosphates.
Her antinuclear antibodies (ANA) test was strongly positive (>1:320) and showed an anti-centromere
pattern. Anti-extractable nuclear antibody(ENA) assay showed anti-mitochondrial and anti-
CENP B antibodies. Liver biopsy revealed overlap syndrome (primary biliary cholangitis and autoimmune
hepatitis).

:
This patient had celiac disease, primary biliary cholangitis and autoimmune hepatitis. Extensive immunological
workup unexpectedly revealed the presence of anti-centromere protein B (anti-CENP
B) antibodies which are strongly associated with CREST syndrome. Clinical re-evaluation of the
patient gave clues of the evolving CREST syndrome. This case report highlights the importance of
adequate immunological investigations in conjunction with clinical information for adequate patient
management to achieve favorable consequences in the future.

Conclusion:
Patients suffering from an autoimmune disease need special attention as multiple immune-
mediated disorders may be present simultaneously or sequentially during the course of the
disease process. MAS patients are at a higher risk of acquiring infections and tumor development
due to prolonged use of immunosuppressants. These patients need close surveillance for the development
of another autoimmune disease, so as to control the current disease and to prevent future
complications. This case report emphasizes the importance of a multidisciplinary team approach including
an immunologist who may facilitate a better understanding of disorders related to the breakdown
of immune tolerance.
Mining the Proteome of Streptococcus mutans for Putative Drug Targets
Authors: Marimuthu Shakti Chandra Vadhana , Ravinarayanan Haribalaganesh , Rosy Joseph Christina , Sundar Krishnan 
Published: June 2020

Background:
Dental caries is the most common and one of the prevalent diseases in the world. Streptococcus
mutans is one of the major oral pathogen that causes dental caries by forming biofilm on dental tissues, degrading dental
enamel and consequent cavitation in the tissue. In vitro selection of drug targets is a laborious and expensive process and
therefore computational methods are preferable for target identification at initial stage.

Objective:
The present research aims to find new drug targets in S. mutans by using subtractive proteomics analysis which
implements various bioinformatics tools and databases.

Methods:
The proteome of S. mutans UA159 was mined for novel drug targets using computational tools and databases
such as: CD-HIT, BLASTP, DEG, KAAS and CELL2GO.

Results:
Out of 1953 proteins of S. mutans UA159, proteins that are non-redundant, non-homologous to human and nonessential to the pathogen were eliminated. Around 178 proteins already available in drug target repositories were also eliminated. Possible functions and subcellular localization of 32 uncharacterized proteins were predicted. Substantially 13 proteins were identified as novel drug targets in S. mutans UA159 that can be targeted by various drugs against dental caries.

Conclusion:
This study will effectuate the development of novel therapeutic agents against dental carries and other Streptococcal infections.
Between Street Demonstrations and Ballot Box: Tenure Rights, Elections, and Social Movements among the Urban Poor in Jakarta
Authors: Amalinda Savirani  , Guntoro  
Published: June 2020

This article investigates the political participation of urban poor through the People's Network of Urban Poor (Jaringan Rakyat Miskin Kota, JRMK) in Jakarta's 2017 gubernatorial election. It also traces the material aspects of this movement, particularly the issues emphasised by the movement: settlement rights, tenure rights, and livelihood rights. Settlement rights reflect a complex system of agrarian laws in Indonesia, and urban development plans in Jakarta, all of which have been shaped by the contestation of economic and political interests. Tenure and livelihood rights for the urban poor, are heavily steeped in history, with constant threat of forced eviction, As a result the three rights became increasingly tangible and movement became ever more urgent. This article argues that the materiality of social movements influences the urban poor movement political strategies. In this case, the movement created a "political contract" with the candidate who ultimately emerged victorious in the election; owing to the complexity of land and settlement issues, electoral politics offered the most promising strategy. However, movements with different types of 'materiality' could employ other approaches.
A Mechanized Proof of a Textbook Type Unification Algorithm
Authors: Rauber Du Bois André , Ribeiro Rodrigo , Amaro Maycon 
Published: June 2020

Unification is the core of type inference algorithms for modern functional programming languages, like Haskell and SML. As a first step towards a formalization of a type inference algorithm for such programming languages, we present a formalization in Coq of a type unification algorithm that follows classic algorithms presented in programming language textbooks. We also report on the use of such formalization to build a correct type inference algorithm for the simply typed λ-calculus.
Validación de un instrumento para medir satisfacción de usuarios en instituciones educativas del sector privado: ciudad de Xalapa-Enríquez (México)
Authors: Montero-Mora Judith Guadalupe , Cantón-Croda Rosa María 
Published: June 2020

RESUMEN:

La satisfacción del cliente es un tema de gran importancia para toda organización que desee lograr una ventaja competitiva, ya que los clientes satisfechos serán fieles a la empresa. Las instituciones educativas no son ajenas a esta realidad. En el contexto empresarial, existen diferentes instrumentos para medir satisfacción de clientes, algunos de uso mundial, que se han adaptado al contexto educativo, como las escalas SERVQUAL y SERVPERF. Existen instrumentos diseñados específicamente para medir la satisfacción de usuarios de instituciones de educación enfocados sólo en universidades públicas y privadas, donde el entrevistado es el usuario directo (estudiante). El objetivo del trabajo fue desarrollar y validar un instrumento para medir satisfacción de usuarios de instituciones educativas del sector privado, aplicable a usuarios indirectos: padres de familia de estudiantes en niveles básicos, a usuarios directos: estudiantes en bachillerato, nivel superior (licenciatura y posgrado) y a capacitación para el trabajo. El diseño y la validación del instrumento se realizaron aplicando el método Delphi en dos rondas, con la participación de 12 expertos. El instrumento final se aplicó a una muestra piloto de 50 usuarios; con esta muestra se validó utilizando el Alfa de Cronbach y se obtuvo un valor de 0,98. El resultado fue un instrumento con 24 ítems, 22 en una escala diferencial semántico con valores de 1 a 7 y dos preguntas abiertas. Se considera que este instrumento es un recurso apropiado que aporta elementos para la planeación de la estrategia de negocio a quienes toman decisiones en el sector educativo privado.
Autonomía universitaria y libertad de cátedra en tiempos de cambio
Authors: Campos-Céspedes Jensy , Solano-Gutiérrez Walter 
Published: June 2020

Se ofrece una discusión sobre los conceptos de autonomía universitaria y la libertad de cátedra, a la luz de su necesaria reconceptualización en las actuales sociedades, caracterizadas por la obsolescencia del conocimiento y la desconfiguración de los grandes relatos que estructuraban los discursos y quehaceres de las instituciones universitarias de antaño. La virtualización, la emergencia de la figura de prosumidores y el desarrollo de las tecnologías de la información y la comunicación, entre otros avances, demanda una reconfiguración de las instituciones universitarias en cuanto a lo que tradicionalmente se ha concebido como libertad de cátedra y autonomía universitaria.
METHODS OF INDIVIDUAL TRAINING OF ENGINEERING PERSONNEL IN THE CONDITIONS OF DIGITALIZATION OF EDUCATION
Authors: Попов Андрей Иванович , Майстренко Наталья Владимировна , Букин Александр Александрович 
Published: June 2020

Проанализированы различные формы освоения образовательной профессиональной программы, показана востребованность обучения по индивидуальному учебному плану и исследованы особенности контингента обучающихся. Обоснована важность развития универсальных компетенций и выделены ключевые из них в контексте подготовки к инновационной деятельности. Сформулированы психолого-педагогические условия эффективной подготовки технических специалистов по заочной форме. Описан организационный механизм индивидуализации обучения в цифровом пространстве на основе компетентностного профиля.Various forms of mastering the educational professional program are analyzed, the advantages and disadvantages of self-education in the digital space and distance learning are considered. The article shows the demand for training according to an individual curriculum and examines the features of the contingent of students that cause the problem of developing a special methodology for their individual training for activities in the conditions of the emerging innovative economy. The author substantiates the importance of developing universal competencies, including a cluster of creative professional competencies, readiness to work in conditions of psychological stress, digital literacy, mathematical analytical thinking, and spiritual and moral qualities. Psychological and pedagogical conditions for effective training of technical specialists by correspondence are formulated, which assume consideration of the needs of participants in the educational process, cognitive abilities and competence profile. It is proposed to use impulse educational technologies, adaptive management of the process of students’ development and intensification of independent work in the digital space. Special attention is paid to the need to strengthen education in order to prepare for engineering creativity. It is advisable to design a personal educational track with the help of a tutor. The organizational mechanism of individualization of training in the digital space based on the competence profile is described. At the first level of individualization, an individual plan is developed. At the second level, on the basis of a digital competence profile, students’ educational activities are managed during the semester. The organization of individual training of technical specialists in correspondence form with the maximum use of the potential of digitalization of education will improve the quality of education and provide an advanced level of formation of the competencies demanded by the customer, to achieve a more complete satisfaction of students with the educational services provided.
Can discounts expand local and digital currency awareness of individuals depending on their characteristics?
Authors: Ključnikov Aleksandr , Civelek Mehmet , Vozňáková Iveta , Krajčík Vladimír 
Published: June 2020

Research background: Because of enabling a greater amount of money circulation and addressing the needs of individuals in specific regions, local and digital currencies have become more important for local economic and sustainable development, especially in last decade. However, their awareness by potential users have become one of major constraints to their extensive usage. In this regard, discount have been used to increase the awareness of individuals.
Purpose of the article: As discount is used as an effective promotional tool. This study pays regard to this indicator and aims to investigate whether the discount rate is positively associated with local and digital currency awareness of potential users. Moreover, this research also includes job positions and age of the respondents into the analyses due to potential existence of differences in the awareness of people regarding their characteristics.
Methods: The research employs a questionnaire survey and acquires data from 407 workers of a local business in Cieszyn Silesia region of the Czech Republic. The researchers run Binary Logistic Regression analyses in IBM SPSS Software to examine the relationship between these specified variables.
Findings & Value added: The research substantiates the fact that potential users who demand more discount rates are more likely to be aware of local and digital currencies. Moreover, potential users who work in lower job positions and demand more discounts are more acquainted with these currencies. Although the existence of a relationship between age and local currency awareness is not proved, older people who demand discounts with higher percentages are more informed about digital currencies than younger individuals. Higher elasticity in discount demand, mutual interactions and relations, such as social media and internet usage of potential users, might be the reasons of these results. This study makes significant contributions to the literature by confirming the significance of individuals? ages and occupational statuses in the awareness of local and digital currencies and the positive relationship between their discount propensity and awareness.
Sözleşmeli Tarımsal Üretim: DİTAP Modeli
Authors: PAKDEMİRLİ Bekir 
Published: June 2020

Amaç: Küçük ölçekli çiftçilerin modern tedarik zincirlerine katılımı, yoksulluğun azaltılması ve kırsal ekonomik kalkınma açısından oldukça önemlidir. Sözleşmeli üretim, çiftçilerin üretim risklerini azaltma, girdilere ve teknolojilere yapılan yatırımları artırma ve böylece daha yüksek verimlilik ve gelire erişme potansiyeli ile piyasa başarısızlıklarına kurumsal bir yanıt olarak ortaya çıkmıştır. Bu çalışmanın amacı sözleşmeli üretimi tanımlamak, dünyada ve Türkiye'de tarihsel gelişim sürecini betimlemek, başarılı örnekleri tanıtmak ve Tarım ve Orman Bakanlığı tarafından kurulan DİTAP platformu sözleşmeli üretim modelini irdelemektir.Tasarım/metodoloji/yaklaşım: Bu çalışmada literatürde yer alan önemli çalışmalardan hareketle öncelikle sözleşmeli üretime yönelik kavramsal bir analiz yapılmıştır. Bu kapsamda sözleşmeli üretim kavramı açıklanmış, tarihsel gelişimi ortaya konulmuş ve dünyada ve Türkiye'de sözleşmeli üretimin mevcut durumu incelenmiştir. Son olarak, Tarım ve Orman Bakanlığının kurmuş olduğu sözleşmeli üretim platformunun yapısı, işleyişi ve kırsal kalkınmaya olan katkısı irdelenmiştir.Bulgular: Tarihsel gelişim süreci ve dünya ekonomilerindeki mevcut durum incelendiğinde sözleşmeli üretimin kırsal ekonomik kalkınmaya destek olduğu, Türkiye'nin sözleşmeli üretim potansiyelinin yüksek olduğu, bu kapsamda DİTAP'ın ülkemiz tarım politikalarını destekleyecek önemli bir platform olduğu belirlenmiştir. Özgünlük/değer: Bu çalışma sözleşmeli üretimin özellikle gelişmekte olan ülkelerde kırsal kalkınma için önemli bir araç olduğunu göstermesi ve Türkiye uygulamasını irdelemesi açısından değerlidir.
Analisis Tanggung Jawab Pegadaian Syariah Palu Plaza Terhadap Barang Jaminan yang Hilang dan Rusak
Authors: Malarangan Hilal , Irfan Irfan , Haekal Ahmad , Istiqamah Rabaniyah 
Published: June 2020

Tulisan ini membahas tanggung jawab pengadaian syariah terhadap barang jaminan yang hilang dan rusak. Pokok permasalahan adalah bagaimana bentuk tanggung jawab pegadaian syariah apabila barang jaminan yang dititipkan nasabah mengalami kehilangan dan kerusakan. Apakah bentuk tanggung jawab pegadaian syariah sudah sesuai dengan tinjauan ekonomi Islam. Penelitian ini menggunakan metode kualitatif, dengan mengumpulkan data-data melalui, observasi, interview (wawancara), kemudian dari dokumen-dokumen. Penulis menggunakan teknik analisis data dengan menggunakan teknik pengumpulan data yang digunakan adalah analisis, dan pengecekan keabsahan data. Hasil penelitian ini menunjukan bahwa tanggung jawab yang diberikan oleh pegadaian syariah Palu Plaza telah sesuai dengan ketentuan ekonomi Islam, yaitu melakukan upaya ansitipasi terhadap barang jaminan nasabah dan memberikan ganti rugi kepada nasabah yang mengalami kehilangan atau kecurian barang jaminannya dengan cara mengganti dengan uang atau mengantinya dengan barang yang sama sesuai dengan kesepakatan bersama antara nasabah dan pihak pegadaian. Ansitipasi yang dilakukan oleh pihak pegadaian syariah selain dari tempat penyimpanan yang dijaga dengan ketat. Pegadaian Syariah juga mengansuransikan barang jaminan tersebut.
Analisis Faktor-Faktor Yang Mempengaruhi Keputusan Nasabah Dalam Memilih Produk Gadai Emas Menurut Perspektif Ekonomi Islam
Authors: Bachmid Sofyan , Musyawarah Indah , Hidayah Noor Riefma , Pratamasyari Dede Arseyani 
Published: June 2020

Penelitian ini bertujuan untuk mengetahui pengaruh nilai taksir, biaya ijarah dan pelayanan terhadap keputusan nasabah memilih produk gadai emas di Bank Syariah Mandiri Cabang Palu secara simultan dan parsial. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif. Penentuan sampel menggunakan teknik non probability sampling dengan metode accidental sampling dan berdasarkan rumus slovin ditentukan jumlah sampel sebanyak 82 orang. Teknik pengumpulan data menggunakan observasi, kuisioner, wawancara dan dokumentasi. Teknik uji dan analisis data meliputi uji validitas, uji reliabilitas, uji asumsi klasik, uji regresi linier berganda dengan uji F dan uji T serta koefisien determinasi dengan menggunakan SPSS 16 for windows. Hasil yang diproleh dari penelitian ini menunjukkan bahwa faktor nilai taksir, biaya ijarah dan pelayanan berpengaruh secara signifikan terhadap keputusan nasabah memilih produk gadai emas dengan nilai F hitung sebesar 10.146 > F tabel 2,72 dengan nilai sig sebesar 0,000. Nilai taksir tidak memiliki pengaruh yang signifikan dikarenakan F hitung 1,764 < F tabel 1,994 dengan sig 0.082 > 0.05 dengan besar pengaruh sebesar 17,7 %, biaya ijrah memberikan pengaruh yang signifikan dengan nilai F hitung 2,705 > F tabel 1,994 dengan sig 0.008 < 0.05 dengan besar pengaruh sebesar 27,1%, dan pelayanan sangat berpengaruh sangat signifikan dengan nilai F hitung 4,558 > F tabel 1,994 dengan sig 0.000 < 0.05 dengan besar pengaruh 44,2%, dengan koefisien determinasi sebesar 28,1% dan 71,9% dipengaruhi oleh variabel lain tidak diteliti dalam penelitianini. Melalui penelitian ini diharapkan bank tetap mempertahankan dan meningkatkan pelayanan dan biaya ijarah serta diharapkan agar bank lebih memperhatikan nilai taksir agar nasabah lebih mengetahui nilai taksir emas beredar pada saat itu.
KARAKTERISTIK PEWARNA ALAMI DARI EKSTRAK KULIT BUAH JERUK MANDARIN (Citrus reticulata) PADA PERBANDINGAN PELARUT ETANOL DAN KLOROFORM
Authors: Saraswati Sagung Ayu Bulan Julia , Wrasiati Luh Putu , Wartini Ni Made 
Published: June 2020

Orange fruit who be the superior commodity is known as a fruit who rich of its vitamin C. One kind of orange who really liked by the society is Mandarin Orange (Citrus reticulata) that comes from China. The aims of this research were to know the effect of ethanol and chloroform solvent ratio to the characteristic of the natural colorant from Mandarin orange peel extract and determine the best ethanol and chloroform solvent ratio which produced Mandarin orange peel extract as natural colorant. Experimental design in this research used Randomized Block Design by using the comparison of ethanol and chloroform solvents that consist of 6 levels, there are: ethanol : chloroform (0:10); ethanol : chloroform (2:8); ethanol : chloroform (4:6); ethanol : chloroform (6:4); ethanol : chloroform (8:2); ethanol : chloroform (10:0). The treatment was repeated as many as 3 repetitions then obtained 18 units of the experiment. The data were analyzed by variance and if the treatment had a effect on the variable then continued with Duncan test. The result showed that ethanol and chloroform solvent ratio had significant effect on the yield, the total carotenoids content, the level of brightness (L*), the level of redness (a*), the level of yellowness (b*) of Mandarin orange peel extract. Based on the results of index effectiveness test used five expert, the ethanol and chloroform solvent ratio of 0 :10 produced the best characteristic of Mandarin orange peel extract with the yield 4.83 ± 0.22f (%), the total carotenoids content 3.56 ± 0.20a (%), the level of brightness (L*) 31.34 ± 0.63d, the level of redness (a*) 28.39 ± 0.69a, and the level of yellowness (b*) 34.52 ± 0.18a.
Keywords : Citrus reticulata, extraction, ethanol, chloroform, natural colorant
KARAKTERISTIK ENKAPSULAT PEWARNA FUNGSIONAL DARI EKSTRAK SELADA LAUT (Ulva lactuca L) PADA PERLAKUAN PERBANDINGAN GELATIN DAN MALTODEKSTRIN
Authors: Fridayana I Wayan Eko , Wrasiati Luh Putu , Ganda Putra G.P 
Published: June 2020

Sea lettuce can be used as a functional green dye because it contains chlorophyll. Chlorophyll compounds as green coloring are obtained by extraction and stored in the form of encapsulation powder. This study has two purpose, there are to knowing the effect of the gelatin-maltodextrin encapsulant ratio on the encapsulates charagcteristics of sea lettuce functional coloring extract and determine the encapsulates comparison treatment of the best gelatin-maltodextrins in producing the characteritic encapsulates extract of sea lettuce functional coloring. Experiments in this study using a Randomized Single Factor Group with treatment ratio of gelatin and maltodextrin consisting of 9 levels, namely (1:0), (1:1), (1:1,5), (1:2), (1:2,5), (1:3), (1:3,5), (1:4), and (0:1). The results showed that the ratio of gelatin-maltodextrin was highly significant (P<0.01) on yield, total chlorophyll content, solubility, brightness level, significantly (P<0.05) on the level of redness (a*), yellowish level (b*) and no effect (P>0.05) on water content. The treatment of gelatin-maltodextrin 1:2,5 ratio is the best treatment to produce encapsulate sea lettuce extract with yield of 10.38%, water content of 8.61%, total chlorophyll content of 20.59 ppm, solubility of 0.80%, brightness level (L*) 45.21, redness level (a*) 1.68 and yellowish level (b*) 13.88.
Keywords :Sea lettuce extract, gelatin, maltodextrin, encapsulation.