bluuebunny/crossref_metadata_2025_split huggingface dataset:
LArSoft and Future Framework Directions at Fermilab
Authors: Knoepfel Kyle 
Published: November 2020

The diversity of the scientific goals across HEP experiments necessitates unique bodies of software tailored for achieving particular physics results. The challenge, however, is to identify the software that must be unique, and the code that is unnecessarily duplicated, which results in wasted effort and inhibits code maintainability.
Fermilab has a history of supporting and developing software projects that are shared among HEP experiments. Fermilab’s scientific computing division currently expends effort in maintaining and developing the LArSoft toolkit, used by liquid argon TPC experiments, as well as the event-processing framework technologies used by LArSoft, CMS, DUNE, and the majority of Fermilab-hosted experiments. As computing needs for DUNE and the HL-LHC become clearer, the computing models are being rethought. Presented here are Fermilab’s plans for addressing the evolving software landscape as it relates to LArSoft and the data-processing frameworks, specifically as it relates to the DUNE experiment.
Evolution of the CERNBox platform to support the Malt project
Authors: González Labrador Hugo , Bippus Vincent Nicolas , Bukowiec Sebastian , Castro Diogo , Dellabella Sebastien , Kwiatek Michal , Lo Presti Giuseppe , Mascetti Luca , Mościcki Jakub T. , Puentes Esteban , Seweryn Piotr Jan , Smyrnakis Apostolos 
Published: November 2020

CERNBox is the CERN cloud storage hub for more than 25,000 users at CERN. It allows synchronising and sharing files on all major desktop and mobile platforms (Linux, Windows, MacOSX, Android, iOS) providing universal, ubiquitous, online- and offline access to any data stored in the CERN EOS infrastructure. CERNBox also provides integration with other CERN services for big science: visualisation tools, interactive data analysis and real-time collaborative editing.Over the last two years, CERNBox has evolved from a pure cloud sync and share platform into a collaborative service, to support new applications such as DrawIO for diagrams and organigrams sketching, OnlyOffice and Collabora Online for documents editing, and DXHTML Gantt for project management, as alternatives to traditional desktop applications. Moving to open source applications has the advantage to reduce licensing costs and enables easier integration within the CERN infrastructure. This move from commercial software to open source solutions is part of the MALT project, led by the IT department at CERN to reduce the dependencies on commercial solutions.As part of the MALT project, CERNBox is the chosen solution to replace Home directories of the Windows DFS file system. Access to storage from Windows managed devices for end-users is largely covered by synchronization clients. However, online access using standard CIFS/SMB protocol is required for shared use-cases, such as central login services (Terminal Services) and visitor desktop computers. We present recent work to introduce a set of Samba gateways running in High Availability cluster mode to enable direct access to the CERNBox backend storage (EOS).
Underwater cap-assisted endoscopic retrograde cholangiopancreatography in patients with surgically altered anatomy: a pilot study
Authors: Fugazza Alessandro , Anderloni Andrea , Paduano Danilo , Badalamenti Matteo , Maselli Roberta , Carrara Silvia , Gabbiadini Roberto , Colombo Matteo , Spadaccini Marco , Cappello Annalisa , Haber Gregory , Repici Alessandro 
Published: November 2020

Abstract

Introduction Endoscopic retrograde cholangiopancreatography (ERCP) in patients with surgically altered anatomy (SAA) is technically challenging and associated with a significant number of failures. We examined the feasibility and efficacy of a novel technique for the management of bile duct stones (BDSs), called underwater cap-assisted ERCP (u-ERCP).
Methods Between June 2019 and February 2020 all patients with SAA with jaundice or cholangitis secondary to BDSs who underwent u-ERCP were enrolled. The u-ERCP technique combines the underwater advancement of a pediatric colonoscope with a transparent cap fitted on the tip of the endoscope. We evaluated the technical success, clinical success, and adverse events associated with u-ERCP.
Results We describe the technique itself and our initial experience in six patients. A complete and successful procedure was carried out in all patients, with the occurrence of no adverse events. None of the patients needed additional treatments for recurrence of symptoms during the follow-up period.
Conclusions u-ERCP can be considered as a promising alternative for successful endoscopic management of biliary disease in patients with SAA.
Fine-needle aspiration of pancreatic cystic lesions: a randomized study with long-term follow-up comparing standard and flexible needles
Authors: Al-Haddad Mohammad , Wallace Michael B. , Brugge William , Lakhtakia Sundeep , Li Zhao-Shen , Sethi Amrita , Pleskow Douglas , Nguyen Cuong C. , Pannala Rahul , DeWitt John , Raimondo Massimo , Woodward Timothy A. , Ramchandani Mohan J. , Jin Zhendong , Xu Can , Faigel Douglas O. 
Published: November 2020

Abstract
Background Pancreatic cystic lesions (PCLs) are increasingly found on cross-sectional imaging, with the majority having a low risk for malignancy. The added value of fine-needle aspiration (FNA) in risk stratification remains unclear. We evaluated the impact of three FNA needles on diagnostic accuracy, clinical management, and the ability to accrue fluid for tumor markers.
Methods A multicenter prospective trial randomized 250 patients with PCLs ≥ 13 mm 2:1:1 to 19G Flex, 19G, and 22G needles with crossover for repeated FNA procedures. Diagnostic accuracy was established at 2-year follow-up, with the final diagnosis from surgical histopathology or consensus diagnosis by experts based sequentially on clinical presentation, imaging, and aspirate analysis in blinded review.
Results Enrolled patients (36 % symptomatic) had PCLs in the head (44 %), body (28 %), and tail (26 %). Percentage of cyst volume aspirated was 78 % (72 % – 84 %) for 19G Flex, 74 % (64 % – 84 %) for 22G, and 73 % (63 % – 83 %) for 19G (P = 0.84). Successful FNA was significantly higher for 19G Flex (89 % [82 % – 94 %]) and 22G (82 % [70 % – 90 %]) compared with 19G (75 % [63 % – 85 %]) (P = 0.02). Repeated FNA was required more frequently in head/uncinate lesions than in body and tail (P < 0.01). Diagnostic accuracy of the cyst aspirate was 84 % (73 % – 91 %) against histopathology at 2-year follow-up (n = 79), and 77 % (70 % – 83 %) against consensus diagnosis among nonsurgical cases (n = 171). Related serious adverse events occurred in 1.2 % (0.2 % – 3.5 %) of patients.
Conclusions Our study results demonstrate a statistically significant difference among the three needles in the overall success rate for aspiration, but not in the percentage of cyst volume aspirated. Flexible needles may be particularly valuable in sampling cystic PCLs in the pancreatic head/uncinate process.
ISCOs in AdS/CFT
Authors: Berenstein David , Li Ziyi , Simón Joan 
Published: November 2020

Abstract
We study stable circular orbits in spherically symmetric AdS black holes in various dimensions and their limiting innermost stable circular orbits. We provide analytic expressions for their size, angular velocity and angular momentum in a large black hole mass regime. The dual interpretation is in terms of meta-stable states not thermalising in typical thermal scales and whose existence is due to non-perturbative effects on the spatial curvature. Our calculations reproduce the binding energy known in the literature, but also include a binding energy in the radial fluctuations corresponding to near circular trajectories. We also describe how particles are placed on these orbits from integrated operators on the boundary: they tunnel inside in a way that can be computed from both complex geodesics in the black hole background and from the WKB approximation of the wave equation. We explain how these two computations are related.
Transmission-type terahertz beam splitter through all-dielectric metasurface
Authors: Li Jiu-Sheng , Zhou Chen 
Published: November 2020

Abstract
Traditional metal metasurfaces have inherent non radiative losses. In this paper, an all dielectric metasurface is proposed, which can flexibly manipulate the terahertz wave high-efficiency abnormal refraction, beam splitting and orbital angular momentum beam generation. Four kinds of elements are designed to meet the transmission phase at 0.94 THz and the phase difference is about 90°. The 2-bit coding metasurfaces are formed by periodic arrangement of these four coding units along the x-direction, and the different transmission angles can be obtained. Then two coding units with a phase difference of 180° are selected and arranged according to the requirements to achieve beam splitting effect. Finally, the coding units are arranged according to different spiral sample coding sequences to generate single and double vortex beams. It is proved that the near-field distribution and far-field scattering patterns extracted from the full wave simulation are in good agreement with the theoretical results under vertical incidence of the transverse electric-mode terahertz wave. This design provides an effective way to manipulate electromagnetic waves with high efficiency.
Promoting rebound of impinging viscoelastic droplets on heated superhydrophobic surfaces
Authors: Li Bin , Lin Shiji , Wang Yile , Yuan Quanzi , Joo Sang W , Chen Longquan 
Published: November 2020

Abstract
The rebound of impinging droplets is a defining characteristic of superhydrophobic surfaces; yet, such an intriguing interfacial phenomenon can be effectively suppressed by adding a tiny amount of flexible polymers to induce non-Newtonian viscoelastic properties. In this work, however, we demonstrate the promoting effects of surface heating on the rebound of impinging viscoelastic droplets on superhydrophobic surfaces. The underlying mechanism for the promotion is that the local heat transfer at the liquid–solid interface causes the fast evaporation of the liquid and thus the breakup of the formed viscoelastic filaments, which hinder droplet recoiling. Therefore, the lower threshold velocity for rebound increases while the upper threshold velocity for rebound suppression decreases with increasing surface temperature, resulting in a wider regime for droplet rebound in the impact phase diagram. The surface heating effect on liquid–solid interactions also leads to a nontrivial dependence of the contact time on the impact velocity and a linear decrease of the restitution coefficient with the Weber number for diverse bouncing viscoelastic droplets, which can be rationalized by coupling the interfacial force and energy analyses. We envision that these findings would be useful in technological processes requiring control the retention of viscoelastic liquids on solid surfaces.
Complex bursting dynamics of a Mathieu-van der Pol-Duffing energy harvester
Authors: Ma Xindong , Jiang Wen-an , Zhang Xiaofang , Han Xiujing , Bi Qinsheng 
Published: November 2020

Abstract
The purpose of this paper aims to explore the mechanism of several different periodic bursting patterns based on a Mathieu-van der Pol-Duffing energy harvester with parameter excitation. These bursting patterns are categorized as ‘delayed supHopf/supHopf’ bursting, ‘delayed pitchfork/pitchfork’ bursting, ‘delayed Hopf-pitchfork/Hopf-pitchfork’ bursting, ‘delayed subHopf/supHopf’ bursting and ‘delayed subHopf/fold-cycle’ bursting, respectively. Since bursting oscillations can be created when the trajectory transfers between/among different attractors, which means the amplitude of bursting oscillations may be sufficient to overcome the potential barrier of the energy harvester, and thus it would have potential application value in energy harvesting.
Thermostatistics of a
q
-deformed relativistic ideal Fermi gas
Authors: Hou Xu-Yang , Yan H , Guo Hao 
Published: November 2020

Abstract
In this paper, we formulate a q-deformed many-body theory for relativistic Fermi gas and discuss the effects of the deformation parameter q on physical properties of such systems. Since antiparticle excitations appear in the relativistic regime, a suitable treatment to the choice of deformation parameters for both fermions and antifermions must be carefully taken in order to get a consistent theory. By applying this formulation, we further study the thermostatistic properties of a q-deformed ideal relativistic Fermi gas. It can be shown that even in the noninteracting scenario, the system exhibits interesting characteristics which are significantly different from ordinary Fermi gases. Explicitly, antiparticles may become dominant due to the shift of chemical potential by the deformation parameter q. This may build a solid foundation for further studies of q-deformed relativistic interacting systems. We also apply our model to study the electron gas in a white dwarf. The effect of the deformation parameter on the Chandrasekhar limit is discussed.
Traffic-induced epidemic suppression in multiplex networks
Authors: Chen Jie , Hu Mao-Bin , Wu Yong-Hong , Li Ming 
Published: November 2020

Abstract
Multiplex networks have been proposed as an effective abstract of real complex systems, ranging from multi-modal urban transportation systems to communication systems. In this paper, we investigate a traffic-driven epidemic model in multiplex networks, and derive a theoretical approach to accurately predict the epidemic threshold of each layer. Our results show that the multiplex structure can produce different effects on the epidemic threshold of layers. Interestingly, one important finding is that the epidemic can be completely suppressed in a certain layer. This phenomenon occurs only when the connectivity of layers is very different, and the traffic flow is heterogeneously distributed over the layers. Therefore, epidemic spreading becomes quite distinct among the layers with different amounts of traffic flow. By using mean-field analysis, an explicit expression is derived to detect this traffic-induced epidemic suppression phenomenon. The accuracy of theoretical prediction is assessed in Erdős–Rényi and scale-free multiplex networks.
Dextran-coated superparamagnetic nanoparticles modified with folate for targeted drug delivery of camptothecin
Authors: Al-Musawi Sharafaldin , Albukhaty Salim , Al-Karagoly Hassan , Sulaiman Ghassan M , Jabir Majid S , Naderi-Manesh Hossein 
Published: November 2020

Abstract
Drug delivery vehicles based on magnetic nanoparticles present a promising strategy for cancer treatment, due to controlled targeted treatment, high loading efficiency, and biosafety as compared to traditional drug delivery approaches. In the present study, superparamagnetic iron oxide (Fe3O4) nanoparticles (SPIONs) were synthesised by a co-precipitation approach, stabilised with dextran (DEX), and successfully conjugated with folate (FA) for delivery of camptothecin (CPT) in prostate cancer cells. Size and other characteristics of the modified nanoparticles were measured using scanning electron microscopy (SEM), transmission electron microscopy (TEM), dynamic light scattering (DLS), and zeta-potential. The results demonstrated that the prepared FA-DEX-SPIONs were spherical in shape with an average diameter of 63.31 nm. They had anticancer activity with high CPT loading efficiency in AT3B-1cancer cells, enabling the therapeutic activity of the drug via its active delivery and release at 37 °C in phosphate and citrate buffer solutions. MTT results exhibited no cytotoxicity on rat androgen independent prostate cancer (AT3B-1) and normal human prostate (RWPE-1) cells. In conclusion, FA-DEX-SPION composite is a promising candidate that could be used for the targeted release of CPT anti-cancer drug.
Structural and mechanical properties study of CNx/MoS2 multilayer coatings obtained by sputtering
Authors: Gutiérrez-Peralta Aime M , Cruz-Valeriano Edgar , Ávila-Herrera Carlos , Flores Christian I Enríquez , Zambrano Gustavo , Morales-Hernández Jorge , Palmerin Joel Moreno , Yañez-Limón José M 
Published: November 2020

Abstract
This work documents the study of samples of CNx/MoS2 multilayer coatings, deposited by magnetron sputtering technique, using 10% and 16% of N2 concentration in the Ar/N2 gas mixture to obtain two sample sets with different nitrogen concentrations in the CNx layers. The samples were grown on Si (100) and AISI 304 steel substrates to carry out different characterizations. The microstructure of the samples was investigated by scanning electron microscopy (SEM), atomic force microscopy (AFM) and x-ray diffraction (XRD). The chemical structure and vibrational modes present in the multilayer coatings were evaluated using x-ray photoelectron spectroscopy (XPS), and Raman spectroscopy, respectively. The analysis revealed that the CNx layers are amorphous, while the MoS2 layers show a polycrystalline structure with basal planes perpendicular to the substrate surface. Finally, the mechanical properties were evaluated by nanoindentation and pin on disk tests, respectively. The results revealed that the concentration of N in the CNx layer is fundamental in determining the mechanical properties. In the test carried out in a humid environment, the samples with the lowest concentration of N in the CNx layers present lower values in the coefficient of friction.
On the wave equation with multiplicities and space-dependent irregular coefficients
Authors: Garetto Claudia 
Published: November 2020

In this paper we study the well-posedness of the Cauchy problem for a wave equation with multiplicities and space-dependent irregular coefficients. As in Garetto and Ruzhansky [Arch. Ration. Mech. Anal. 217 (2015), pp. 113–154], in order to give a meaningful notion of solution, we employ the notion of very weak solution, which construction is based on a parameter dependent regularisation of the coefficients via mollifiers. We prove that, even with distributional coefficients, a very weak solution exists for our Cauchy problem and it converges to the classical one when the coefficients are smooth. The dependence on the mollifiers of very weak solutions is investigated at the end of the paper in some instructive examples.
Can Visual Cues to Portion Size Reduce the Number of Portions of Consumed? Two Randomized Controlled Trials
Authors: Robertson Deirdre A , Lavin Ciarán , Lunn Peter D 
Published: November 2020

Abstract

Background
Since 1950, the portion size of many snack foods has more than doubled and obesity rates have tripled. Portion size determines energy intake, often unwittingly.

Purpose
This paper tests whether salient visual cues to portion size on the packaging of high fat, sugar, or salty (HFSS) snacks can reduce consumption.

Methods
Two preregistered randomized controlled trials (N = 253 and N = 674) measured consumption in a lab and the home environment. Cues were salient, labeled stripes that demarcated single portions. Participants were randomized to cue condition or control. Consumption was measured without awareness.

Results
The main preregistered effect of the visual cue was not statistically significant. There was some variation by subgroup. In Study 1, men were more likely to eat the whole can of potato chips than women but significantly reduced consumption when visual cues were on the pack. The effect size was large: the number of men eating more than the recommended portion fell by 33%. Study 2 monitored household consumption of chocolate biscuits (cookies) sent to family homes in gift packs. Again, the main effect was nonsignificant but there was significant subgroup variation. When the person receiving the biscuits was female, households were more likely to eat more than the recommended portion per person per day, but less likely when the visual cues were displayed. The gender of the eaters was not known. The effect size was again large: the number of households eating more than the recommended portion fell by 26%. Households with children were also less likely to open packs with visual cues compared to control packs. Both studies recorded significant increases in the likelihood of observing serving size information, together with confusion about what it means.

Conclusions
The studies offer some evidence that salient visual cues could play a role in tackling the high consumption of unhealthy snacks, but the effects are confined to specific subgroups and warrant further investigation.
Safety of hydroxychloroquine and darunavir or lopinavir in COVID-19 infection
Authors: Meriglier Etienne , Rivoisy Claire , Hessamfar Mojgan , Bernard Noelle , Aureau Ines , Lapoirie Joelle , Contis Anne , Sacher Frédéric , Sacristan Benjamin , Lahouati Marin , Pedeboscq Stéphane , Vandenhende Marie-Anne , Bouchet Stéphane , Bonnet Fabrice 
Published: November 2020

Abstract

Background
Combination therapy with hydroxychloroquine and darunavir/ritonavir or lopinavir/ritonavir has been suggested as an approach to improve the outcome of patients with moderate/severe COVID-19 infection.

Objectives
To examine the safety of combination therapy with hydroxychloroquine and darunavir/ritonavir or lopinavir/ritonavir.

Methods
This was an observational cohort study of patients hospitalized for COVID-19 pneumonia treated with hydroxychloroquine and darunavir/ritonavir or lopinavir/ritonavir. Clinical evaluations, electrocardiograms and the pharmacokinetics of hydroxychloroquine, darunavir and lopinavir were examined according to clinical practice and guidelines.

Results
Twenty-one patients received hydroxychloroquine with lopinavir/ritonavir (median age 68 years; 10 males) and 25 received hydroxychloroquine with darunavir/ritonavir (median age 71 years; 15 males). During treatment, eight patients (17.4%) developed ECG abnormalities. Ten patients discontinued treatment, including seven for ECG abnormalities a median of 5 (range 2–6) days after starting treatment. All ECG abnormalities reversed 1–2 days after interrupting treatment. Four patients died within 14 days. ECG abnormalities were significantly associated with age over 70 years, coexisting conditions (such as hypertension, chronic cardiovascular disease and kidney failure) and initial potential drug interactions, but not with the hydroxychloroquine concentration.

Conclusions
Of the patients with COVID-19 who received hydroxychloroquine with lopinavir or darunavir, 17% had ECG abnormalities, mainly related to age or in those with a history of cardiovascular disease.