bluuebunny/crossref_metadata_2025_split huggingface dataset:
PTFE as a toughness modifier of high‐performance PEI/PBT blends: Morphology control during melt processing
Authors: Vásquez‐Rendón Mauricio , Álvarez‐Láinez Mónica Lucía 
Published: October 2020

High‐performance PEI/PBT blends are brittle because of phase distribution and blends densification. New morphologies developed by adding PTFE to PEI matrix during melt processing favor the toughness improvement of PEI/PBT blends. Ternary PEI/PBT/PTFE processability is not compromised by PTFE addition, and miscibility study by modulated differential scanning calorimetry and harmonic mean method shows that PTFE does not interfere with PEI and PBT interaction. Dual‐phase and spore‐like morphologies are formed for both PEI/PBT and PEI/PBT/PTFE blends, and they strongly influenced their mechanical performance. Although tensile strength of ternary blends does not decrease by PTFE addition, elongation at break deteriorates for blends with PEI concentrations <70 wt%. Nevertheless, blends with 80 wt% increase their ductility, and a synergic effect is observed in impact resistance results. PTFE acts as an impact modifier of PEI/PBT blends due to its distribution in the PEI matrix as debonded spheres and nanoparticles well‐embedded in PEI matrix.Highlights
Step‐by‐step melt processing enhances PTFE powders spheroidization
Complete wetting of PTFE in PEI matrix
PTFE do not interfere in partial miscibility of PEI/PBT blends
Nanosized PTFE droplets inhibits PEI densification
PTFE improves elongation at break and toughness of PEI/PBT blends
Clinical utilization of blinatumomab and inotuzumab immunotherapy in children with relapsed or refractory B‐acute lymphoblastic leukemia
Authors: Contreras Cristina F. , Higham Christine S. , Behnert Astrid , Kim Kailyn , Stieglitz Elliot , Tasian Sarah K. 
Published: October 2020

AbstractBackgroundThe treatment paradigm for patients with relapsed/refractory B‐cell acute lymphoblastic leukemia (rrALL) has been revolutionized given recent clinical trials demonstrating remarkable success of immunotherapies and leading to drug approvals by United States and European agencies. We report experience with commercial blinatumomab and inotuzumab use at two North American pediatric oncology centers in children and adolescents/young adults with B‐ALL.ProcedurePatients 0‐25 years old treated with the CD19 × CD3 bispecific T cell‐engaging antibody blinatumomab and/or the CD22 antibody‐drug conjugate inotuzumab from January 1, 2010, to June 1, 2018, were eligible. Disease status included relapsed B‐ALL in second or greater relapse, primary chemotherapy‐refractory B‐ALL, or B‐ALL complicated by severe infection precluding delivery of conventional chemotherapy.ResultsWe identified 27 patients who received blinatumomab and/or inotuzumab outside of clinical trials during the study period. Four of the 13 patients (31%) with relapsed disease achieved minimal residual disease (MRD)‐negative remission, and five patients (39%) underwent hematopoietic stem cell transplant (HSCT). In the 12 patients with primary chemorefractory B‐ALL treated with immunotherapy, 11 (92%) achieved MRD‐negative remission as assessed by flow cytometry; 10 patients (83%) underwent subsequent HSCT. Two patients with B‐ALL in MRD‐negative remission received blinatumomab due to severe infection and remained in remission after chemotherapy continuation.ConclusionsBlinatumomab and inotuzumab can induce deep remissions in patients with rrALL and facilitate subsequent HSCT or other cellular therapies. Blinatumomab can also serve as an effective bridging therapy during severe infection. The optimal timing, choice of immunotherapeutic agent(s), and duration of responses require further investigation via larger‐scale clinical trials.
A novel hybrid polyurethane composites with ZnO particles and sheath palm residues: Synergistic effect
Authors: Zanini Noelle C. , de Souza Alana G. , Barbosa Rennan F. S. , Rosa Derval S. , Mulinari Daniella R. 
Published: October 2020

AbstractTechnological advances related to the development of new sustainable materials have driven the search for composites containing green fillers. Polyurethane (PU) composites with natural fibers have stood out; however, these materials have limited mechanical and thermal properties. This study developed hybrid PU composites filled with ZnO and palm sheath residues and evaluated the fiber loading (0, 5, 10, 15, and 20 wt%) on morphological, chemical, thermal, crystalline, and mechanical properties. Microscopic and scanning electron microscopy images showed that ZnO promoted homogeneous and isotropic cell structures. Sheath palm residues were well dispersed throughout the PU matrix and increased the foam's density and further decreased the cell sizes due to limited expansion caused by the fibers that altered nucleation and growth mechanisms. Strong hydrogen bonds formed between the fillers and the PU matrix resulted in a new network that improved thermal resistance. Also, crystallinity enhanced PU chains' organization due to filler incorporation, and these changes on the PU matrix increased impact resistance. The best results were obtained for the hybrid PU composite with 20 wt% of palm fiber. The properties improvements show the reinforcements' character in PU foams with environmentally friendly materials.
New prescription of antihyperglycemic agents among patients with diabetes in Germany: Moderate concordance between health insurance data and self‐reports
Authors: Brüne Manuela , Andrich Silke , Haastert Burkhard , Kaltheuner Matthias , Icks Andrea 
Published: October 2020

AbstractPurposeTo analyze the concordance of new prescription of antihyperglycemic agents between two data sources: patients' self‐reports and statutory health insurance (SHI) data among patients with diabetes.MethodsWithin a cross‐sectional study, 494 patients with diabetes were interviewed if and which new prescriptions of diabetes medication they received within the last 3 or 6 months. SHI data for 12 months were linked to cover these periods. For the agreement measurement, SHI data was set as reference, and kappa, positive predictive value (PPV), and sensitivity were calculated for single Anatomical Therapeutic Chemical (ATC) codes and cumulated code groups.ResultsThe number of new prescriptions within 3 or 6 months was low, with 5.5% (n = 27) for Metformin/self‐report being the highest. Contingency tables were unbalanced and showed large numbers in the no/no‐cells. Regarding non‐agreement, we found new prescriptions slightly more often in SHI data only than in self‐reports only, with insulin and metformin representing an exception. Agreement results were moderate with large confidence intervals (CI). The values for cumulated “all drugs in diabetes” were: kappa = 0.58 (95% CI: 0.51‐0.65), PPV = 62.0 (53.4‐70.2), sensitivity = 55.6 (47.3‐63.6).ConclusionsPatients reported a low number of new prescriptions within the last 3 or 6 months. In general we found moderate agreement and in case of non‐agreement that self‐report no/SHI yes was slightly more frequent than vice versa. These results were based on small case numbers, but could nevertheless be considered when collecting self‐reported information on the prescription of antihyperglycemic agents.
Characterization of Telehealth Use in Veterans With Spinal Cord Injuries and Disorders
Authors: Hatch Maya N. , Martinez Rachael N. , Etingen Bella , Cotner Bridget , Hogan Timothy P. , Wickremasinghe Itala M. , Sippel Jennifer , Smith Bridget M. 
Published: October 2020

BackgroundIndividuals with spinal cord injuries and disorders (SCI/D) require frequent interdisciplinary health care to address impairments in mobility, autonomic function, and secondary complications. Telehealth has the capacity to substantially transform health care delivery and improve care by increasing access and communication. However, relatively little is known about telehealth use in this specific population. Here we attempt to fill part of this gap.ObjectiveTo investigate the frequency and characteristics associated with telehealth use in Veterans with SCI/D.DesignCross‐sectional, descriptive project.SettingVeterans Health Administration (VHA) facilities.ParticipantsA total of 15 028 Veterans living with SCI/D who received services from the VHA SCI/D System of Care.InterventionNot applicable.Outcome MeasuresFrequency and characteristics associated with VHA telehealth utilization.ResultsOf the 15 028 Veterans with SCI/D included in the evaluation, 17% used some form of telehealth in VHA Fiscal Year (FY)2017. Veterans older than 65 years of age had lower odds (odds ratio [OR] = 0.88, P < .05, confidence interval [CI] 0.80‐0.98) of using telehealth. Being Caucasian (OR = 1.29, P < .01, CI 1.09‐1.52), living in rural areas (OR = 1.16, P < .01, CI 1.05‐1.28), living greater distances away from the VHA (P < .01 for all distances), and being in priority group 8, meaning that Veterans have higher copayment requirements (OR = 1.46, P < .001, CI 1.19‐1.81), were all significantly associated with greater odds of telehealth use. The most frequent types of telehealth used were real‐time clinical video and store‐and‐forward between a provider and patient within the same hub network.ConclusionThere are opportunities to increase telehealth adoption in the SCI/D arena. The findings from this project highlight which Veterans are currently using telehealth services, as well as gaps regarding telehealth adoption in this population.
Triphilic pentablock copolymers with perfluoroalkyl segment in central position
Authors: Heinz Daniel , Meister Annette , Hussain Hazrat , Busse Karsten , Kressler Jörg 
Published: October 2020

AbstractAdding perfluoroalkyl (PF) segments to amphiphilic copolymers yields triphilic copolymers with new application profiles. Usually, PF segments are attached as terminal blocks via Cu(I) catalyzed azide‐alkyne cycloaddition (CuAAC). The purpose of the current study is to design new triphilic architectures with a PF segment in central position. The PF segment bearing bifunctional atom transfer radical polymerization (ATRP) initiator is employed for the fabrication of triphilic poly(propylene oxide)‐b‐poly(glycerol monomethacrylate)‐b‐PF‐b‐poly(glycerol monomethacrylate)‐b‐poly(propylene oxide) PPO‐b‐PGMA‐b‐PF‐b‐PGMA‐b‐PPO pentablock copolymers by a combined ATRP and CuAAC reaction approach. Differential scanning calorimetry indicates the PF‐initiator to undergo a solid–solid phase transition at 63°C before the final crystal melting at 95°C. This is further corroborated by polarized optical microscopy and X‐ray diffraction studies. The PF‐initiator could successfully polymerize solketal methacrylate (SMA) under typical ATRP conditions producing well‐defined Br‐PSMA‐b‐PF‐b‐PSMA‐Br triblock copolymers that are then converted into PPO‐b‐PSMA‐b‐PF‐b‐PSMA‐b‐PPO pentablock copolymer via CuAAC reaction. Subsequently, acid hydrolysis of the PSMA blocks afforded water soluble well‐defined triphilic pentablock copolymers PPO‐b‐PGMA‐b‐PF‐b‐PGMA‐b‐PPO with fluorophilic central segment, hydrophilic middle blocks, and lipophilic outer blocks. The triphilic block copolymers could self‐assemble, depending upon the preparatory protocol, into spherical and filament‐like phase‐separated nanostructures as revealed by transmission electron microscopy.
Proteome Analyses Reveal S100A11, S100P, and RBM25 Are Tumor Biomarkers in Colorectal Cancer
Authors: Guo Ai‐Jun , Wang Feng‐Jie , Ji Qiang , Geng Hui‐Wu , Yan Xu , Wang Lin‐Qi , Tie Wei‐Wei , Liu Xiao‐Ying , Thorne Rick F. , Liu Gang , Xu A‐Man 
Published: October 2020

PurposeThe prognosis for colorectal cancer (CRC) patients is drastically impacted by the presence of lymph node or liver metastases at diagnosis or resection. On this basis it is sought to identify novel proteins as biomarkers and determinants of CRC metastasis.Experimental DesignProteomic analyses are undertaken using primary tissues from ten Chinese CRC patients presenting with or without liver metastases and immunohistochemistry used to validate selected proteins in an independent patient cohort.ResultsComparing CRC against paired normal adjacent tissues identifies 1559 differentially expressed proteins (DEPs) with 974 upregulated and 585 downregulated proteins, respectively. The highest number of DEPs is selectively associated with metastatic tumors (519 upregulated and 267 downregulated proteins, respectively) with a smaller number of unique DEPs identified only in non‐metastatic CRC cases (116 upregulated and 29 downregulated proteins, respectively). The remaining DEPs are commonly expressed in both non‐metastatic and metastatic tumors. The upregulation of three representative DEPs (S100A11, S100P, and RBM25) is confirmed using immunohistochemistry against 154 CRC tissues embedded in a tissue microarray.Conclusions and Clinical RelevanceThe data reveal both previously identified CRC biomarkers along with novel candidates which provide a ready resource of DEPs in CRC for further investigation.
Anomaly identification with few labeled data in the distillation process based on semisupervised ladder networks
Authors: Li Chuankun , Xu Wei , Zhao Dongfeng , Yuan Zhuang , Shi Jihao , Wang Chunli 
Published: October 2020

AbstractHigh repeatability of similar information but a lack of typical fault features, in the monitoring data of distillation processes for continuous production, leads to a small proportion of data with labels. Therefore, the requirement for a large number of labeled samples in conventional deep learning models cannot be met, resulting in significant performance degradation in their anomaly identification. In this paper, an intelligent anomaly identification method for small samples is proposed, based on semisupervised deep learning. Specifically, on the basis of a deep denoising autoencoder (DAE), semisupervised ladder networks (SSLN) is constructed to use a large number of unlabeled, process data to assist the supervised learning process, thus improving the performance of the anomaly identification model. In order to construct the optimum SSLN model, the influences of parameters such as the number of deep network layers, the proportion of labeled samples, and the noise intensity on identification accuracy are analyzed while making the information flow in the network more efficient. Experimental results of anomaly identification in the depropanization distillation process show that compared with the conventional multilayer perception (MLP) and convolutional neural network (CNN)‐DAE models, the proposed method can obtain a higher diagnostic accuracy in the case with limited labeled process data.
Development of a loop‐mediated isothermal amplification method for the rapid detection of Venturia carpophila on peach
Authors: Zhou Yang , Fan Fei , Wang Li , Chaisiri Chingchai , Yin Liang‐Fen , Yin Wei‐Xiao , Luo Chao‐Xi 
Published: October 2020

AbstractBACKGROUNDPeach scab, caused by Venturia carpophila, can significantly reduce both the yield and quality of peach fruit. It is difficult to distinguish peach scab from other peach diseases such as black spot and bacterial spot. An efficient assay is needed to identify V. carpophila in order to develop scientific management strategies.RESULTSA set of loop‐mediated isothermal amplification (LAMP) primers was designed based on the internal transcribed spacer (rDNA‐ITS) sequence to detect V. carpophila. Compared with the conventional polymerase chain reaction (PCR) method, the LAMP method not only exhibited higher sensitivity and specificity in the detection of V. carpophila, but also required simpler equipment and less operational time. The minimum detectable concentration of V. carpophila genomic DNA with the LAMP method was 56.6 fg μl–1, which was 100 times lower than with the conventional PCR method. When eight fungal species including V. carpophila (23 isolates from 14 provinces) and one bacterial species were used with LAMP detection, only V. carpophila showed a color change, from brown to yellowish green, and ladder‐like bands in electrophoresis, indicating successful amplification. Moreover, when crude DNAs of peach fruit samples were used in LAMP detection, amplification was observed only from diseased fruits, and not from healthy fruits and the negative control.CONCLUSIONThe LAMP assay shows simplicity, rapidity, high sensitivity and specificity, and will be useful in distinguishing scab caused by Venturia carpophila from other diseases with similar symptoms. © 2020 Society of Chemical Industry
IRMOF‐8: Theoretical evaluation of aluminum doping on hydrogen, methane, and hydrogen sulfide adsorption
Authors: Rodrigues Nailton Martins , Lisboa Dutra José Diogo , Martins João B. L. , Freire Ricardo Oliveira 
Published: October 2020

AbstractThe use of porous materials, aimed at increasing gas storage capacity at lower pressures, exploits physical adsorption and is an emerging strategy that is being widely investigated. In this scope, porous materials such as metal organic frameworks (MOFs) are a viable alternative, where structural modifications can enhance the properties of these materials and improve the degree of adsorption for a given gas. In this work, we evaluated the adsorption of methane, hydrogen, and hydrogen sulfide gases on pure isoreticular MOF (IRMOF)‐8 and aluminum‐doped IRMOF‐8 using density functional theory Perdew‐Burke‐Ernzerhof/DZVP and semiempirical AM1, PM3, PM6, PM6‐DH+, PM6‐DH2, PM6‐D3, and PM7 methods. Adsorption isotherms were calculated by means of Grand Canonical Monte Carlo simulations. It was found that doping did not provide a significant increase in the amount of adsorbed methane and hydrogen gases. Conversely, doping led to a considerable increase for hydrogen sulfide capture.
Extremal graphs on geometric‐arithmetic index of tetracyclic chemical graphs
Authors: Balachandran Selvaraj , Deng Hanyuan , Elumalai Suresh , Mansour Toufik 
Published: October 2020

AbstractThe main concern of this article is to present the complete classification of tetracyclic (chemical) graphs and establishing some extremal results with respect to the geometric‐arithmetic index, defined by , where dx denotes the degree of a vertex x in G. In addition, we characterize the extremal graphs of the first and second maximum values of geometric‐arithmetic index of n‐vertex (n ≥ 9) tetracyclic (chemical) graphs.
Generalized quantum similarity index: An application to pseudoharmonic oscillator with isospectral potentials in 3D
Authors: Ghosh Piu , Nath Debraj 
Published: October 2020

AbstractExact solutions of a pseudoharmonic oscillator and a family of isospectral potentials are investigated in spherical coordinates. The entropic moment, generalized quantum similarity index, and some quantum information measures are investigated analytically and numerically for two density functions of two quantum systems with same energy and one quantum system with different energies. Analytical results are compared for 19 selected molecules and verified by some physical and artificial values of the spectroscopic parameters.
Strategies to support teachers' professional development regarding sense‐making in context‐based science curricula
Authors: Dolfing Ria , Prins Gjalt T. , Bulte Astrid M. W. , Pilot Albert , Vermunt Jan D. 
Published: October 2020

AbstractThe aim of this study is to develop more understanding about strategies to support teachers' professional development in curriculum innovations, in which pedagogy and content change simultaneously compared to the conventional curriculum. A pre‐existing framework, including strategies for professional development, was adapted, implemented, and evaluated from the perspective of teachers' sense‐making in teaching context‐based science curricula. This framework guides the design of activities that support teachers' development in three new aspects of teaching context‐based science units: setting a context in class, performing a new teaching role, and teaching new content. In a case study, six teachers in secondary education participated in a professional development program based on the adapted framework. A qualitative inner‐case analysis was conducted to describe teachers' sense‐making during the program, in terms of the categories “assimilation,” “accommodation,” “toleration,” and “distantiation.” Results showed that teachers participating in the professional development program successfully assimilated and accommodated all three aspects; however, the process of teachers' sense‐making of the new content followed a different path compared to the processes of the other aspects. The relation between these results and the adapted framework are discussed to retrieve strategies for planning professional development programs to support teachers in curriculum innovations.
Thermal damage and its controlling methods of high‐speed railway steam‐cured concrete: A review
Authors: Xiang Yu , Long Guangcheng , Xie Youjun , Zheng Keren , He Zhimin , Ma Kunlin , Zeng Xiaohui , Wang Meng 
Published: October 2020

AbstractThe steam curing technology is worldwide applied in the production of concrete prefabricated components, including the production of track slab and girder used for the high‐speed railway in China. However, the steam curing process at elevated temperature will often generate the heat damage on concrete and thus degrade the long‐term performance of the steam‐cured concrete prefabricated components. It is very important to deeply understand the mechanism of heat damage and thus to find effective method reducing or avoiding the damage of steam curing on concrete. The main purpose of this paper is to systematically classify the types of thermal damages on concrete during the steam curing and its mechanism. The influences of main factors on three thermal damages such as the unrecoverable expansion deformation, the surface layer defect, and the embrittlement of the steam‐cured concrete are discussed in detail. The controlling methods of thermal damages including optimization of the steam curing regime and mixing proportions, the addition of supplementary additives, the self‐healing technology, and other curing technology are compared and summarized based on the literatures. Finally, suggestions for future research are proposed in order to effectively reduce or even avoid the thermal damage of the steam‐cured concrete. And also, some new technology for developing the green and high performance early strength concrete with low CO2 emission are presented.
A rediscovered work of Karel B. Presl and other sins of his youth
Authors: Del Guacchio Emanuele , Caputo Paolo 
Published: October 2020

AbstractThe authors announce the rediscovery at the Library of the Botanical Garden of Naples of a document by Karel B. Presl about the flora of Sicily (southern Italy), i.e., (the possible proofs of) the first issue of the Prodromus to his Flora Sicula, after 200 years from its preparation. This document, for reasons unknown, was not widely distributed to scientific institutions and, therefore, cannot be considered as published; in addition, it has been neglected until now, so that it is missing from Presl's bibliography. In spite of this, various botanists of the 19th century refer to this work for protologues. The booklet is bound together with the well‐known first volume of Presl's Flora Sicula, and lacks a title page; consequently, direct information about title, date and possible place of publication are not available. Nevertheless, analyzing other contributions by the same scholar and also biographic and bibliographic information, the authors reconstruct the chronology of the booklet and formulate hypotheses on its origin and about the possible reasons for the choice of not publishing it. The Prodromus is also compared to other Presl publications on the Sicilian flora, often poorly known or forgotten, and especially to his dissertation. Three appendices report a list of the taxa present in these early works by Presl, and various nomenclatural notes.