bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pervasive lesion segregation shapes cancer genome evolution
Authors: Aitken Sarah J. , Anderson Craig J. , Connor Frances , Pich Oriol , Sundaram Vasavi , Feig Christine , Rayner Tim F. , Lukk Margus , Aitken Stuart , Luft Juliet , Kentepozidou Elissavet , Arnedo-Pac Claudia , Beentjes Sjoerd , Davies Susan E. , Drews Ruben M. , Ewing Ailith , Kaiser Vera B. , Khamseh Ava , López-Arribillaga Erika , Redmond Aisling M. , Santoyo-Lopez Javier , Sentís Inés , Talmane Lana , Yates Andrew D. , Semple Colin A. , López-Bigas Núria , Flicek Paul , Odom Duncan T. , Taylor Martin S. 
Published: December 2019

SummaryCancers arise through the acquisition of oncogenic mutations and grow through clonal expansion1, 2. Here we reveal that most mutagenic DNA lesions are not resolved as mutations within a single cell-cycle. Instead, DNA lesions segregate unrepaired into daughter cells for multiple cell generations, resulting in the chromosome-scale phasing of subsequent mutations. We characterise this process in mutagen-induced mouse liver tumours and show that DNA replication across persisting lesions can generate multiple alternative alleles in successive cell divisions, thereby increasing both multi-allelic and combinatorial genetic diversity. The phasing of lesions enables the accurate measurement of strand biased repair processes, the quantification of oncogenic selection, and the fine mapping of sister chromatid exchange events. Finally, we demonstrate that lesion segregation is a unifying property of exogenous mutagens, including UV light and chemotherapy agents in human cells and tumours, which has profound implications for the evolution and adaptation of cancer genomes.
Longitudinal ComBat: A Method for Harmonizing Longitudinal Multi-scanner Imaging Data
Authors: Beer Joanne C. , Tustison Nicholas J. , Cook Philip A. , Davatzikos Christos , Sheline Yvette I. , Shinohara Russell T. , Linn Kristin A. ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: December 2019

AbstractWhile aggregation of neuroimaging datasets from multiple sites and scanners can yield increased statistical power, it also presents challenges due to systematic scanner effects. This unwanted technical variability can introduce noise and bias into estimation of biological variability of interest. We propose a method for harmonizing longitudinal multi-scanner imaging data based on ComBat, a method originally developed for genomics and later adapted to cross-sectional neuroimaging data. Using longitudinal cortical thickness measurements from 663 participants in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) study, we demonstrate the presence of additive and multiplicative scanner effects in various brain regions. We compare estimates of the association between diagnosis and change in cortical thickness over time using three versions of the ADNI data: unharmonized data, data harmonized using cross-sectional ComBat, and data harmonized using longitudinal ComBat. In simulation studies, we show that longitudinal ComBat is more powerful for detecting longitudinal change than cross-sectional ComBat and controls the type I error rate better than unharmonized data with scanner included as a covariate. The proposed method would be useful for other types of longitudinal data requiring harmonization, such as genomic data, or neuroimaging studies of neurodevelopment, psychiatric disorders, or other neurological diseases.
A mutant of the phototoxic protein KillerRed that does not form DsRed-like chromophore
Authors: Gorbachev Dmitry A. , Sarkisyan Karen S. 
Published: December 2019

AbstractWe report a mutant of the phototoxic fluorescent protein KillerRed protein with fluorescence in the green part of the spectrum. The mutant variant carries mutations I64L, D114G, and T115S and does not form a DsRed-like chromophore. The protein can be used as a template to create new genetically encodable photosensitizers that are spectrally different from KillerRed.
SODA: Multi-locus species delimitation using quartet frequencies
Authors: Rabiee Maryam , Mirarab Siavash 
Published: December 2019

AbstractMotivationSpecies delimitation, the process of deciding how to group a set of organisms into units called species, is one of the most challenging problems in evolutionary computational biology. While many methods exist for species delimitation, most based on the coalescent theory, few are scalable to very large datasets and methods that scale tend to be not accurate. Species delimitation is closely related to species tree inference from discordant gene trees, a problem that has enjoyed rapid advances in recent years.ResultsIn this paper, we build on the accuracy and scalability of recent quartet-based methods for species tree estimation and propose a new method called SODA for species delimitation. SODA relies heavily on a recently developed method for testing zero branch length in species trees. In extensive simulations, we show that SODA can easily scale to very large datasets while maintaining high accuracy.AvailabilityThe code and data presented here are available onhttps://github.com/maryamrabiee/SODAContactsmirarab@ucsd.edu
Cell motion-coordinated fibrillar assembly of soluble collagen I to promote MDCK cell branching formation
Authors: Wang Jiajia , Guo Jia , Che Bo , Ouyang Mingxing , Deng Linhong 
Published: December 2019

AbstractExtracellular Matrix (ECM) assembly and remodeling are critical physiological events in vivo, and abnormal ECM assembly or remodeling is related to pathological conditions such as osteoarthritis, fibrosis, cancers, and genetic diseases. ECM assembly/remodeling driven by cells represents more physiological processes. Collagen I (COL) is very abundant in tissues, which assembly/remodeling is mediated by biochemical and mechanical factors. How cells regulate COL assembly biomechanically still remains to be well understood. Here we used fluorescent COL in the medium to study how cells assembled ECM which represents more physiological structures. The results showed that MDCK cells actively recruited COL from the medium and helped assemble the fibers, which in turn facilitated cell branching morphogenesis, both displaying high spatial associations and mutual dependency. Inhibition of cellular contraction force by ROCK and Myosin II inhibitors attenuated but did not block the COL fiber formation, while cell motion showed high consistency with the fiber assembly. Under ROCK or Myosin II inhibition, further analysis indicated high correlation between local cell movement and COL fiber strength as quantified from different regions of the same groups. Blocking cell motion by actin cytoskeleton disruption completely inhibited the fiber formation. These suggest that cell motion coordinated COL fiber assembly from the medium, possibly through generated strain on deposited COL to facilitate the fiber growth.
Transformational leadership, proactive personality and service performance
Authors: Yang Chunjiang , Chen Yashuo , Zhao Xinyuan (Roy) , Hua Nan 
Published: December 2019

PurposeThis paper aims to examine the impacts of transformational leadership and employee proactive personality on service performance, the mediation role of organizational embeddedness and the synergies of transformational leadership and proactive personality within the proposed framework.Design/methodology/approachData was collected following a time-lagged research approach. The study sample included 218 frontline employees and their supervisors from ten carefully selected five-star hotels in China. Structural equation modeling was employed for the data analysis.FindingsTransformational leadership and proactive personality had positive effects on task performance and contextual performance via organizational embeddedness. The interactive influences of transformational leadership and proactive personality on task performance and contextual performance were found significant and negative.Originality/valueTransformational leaders and proactive employees have been shown to exert a strong influence on excellent service performance, with organizational embeddedness playing a critical role.
Perceived contract violation and job satisfaction
Authors: De Clercq Dirk , Haq Inam Ul , Azeem Muhammad Umer 
Published: December 2019

PurposeThis paper aims to investigate how employees’ perceptions of psychological contract violation or sense of organizational betrayal, might diminish their job satisfaction, as well as how their access to two critical personal resources – emotion regulation skills and work-related self-efficacy – might buffer this negative relationship.Design/methodology/approachTwo-wave survey data came from employees of Pakistani-based organizations.FindingsPerceived contract violation reduces job satisfaction, but the effect is weaker at higher levels of emotion regulation skills and work-related self-efficacy.Practical implicationsFor organizations, these results show that the frustrations that come with a sense of organizational betrayal can be contained more easily to the extent that their employees can draw from relevant personal resources.Originality/valueThis investigation provides a more complete understanding of when perceived contract violation will deplete employees’ emotional resources, in the form of feelings of happiness about their job situation. A sense of organizational betrayal is less likely to escalate into reduced job satisfaction when employees can control their negative emotions and feel confident about their work-related competencies.
Analysis on micro-motion of cylinder block based on elasto-hydrodynamic lubrication
Authors: Jiang Jihai , Yan Wei-Peng , Li Ge-Qiang 
Published: December 2019

Purpose
The purpose of this paper is to analyze the micro-motion of the cylinder block.

Design/methodology/approach
Based on the elasto-hydrodynamic lubrication, a numerical model for the cylinder block/valve plate interface is proposed, with consideration of the elastic deformations, the pressure-viscosity effect and asperity contacts. The influence-function method is applied to calculating the actual deformations of the cylinder block and the valve plate. The asperity contact model simplified from Greenwood assumption is introduced into the numerical model. Furthermore, the relationship between the micro-motion and the operating condition, the sealing belt width is discussed, respectively.

Findings
The results show an increase in the discharge pressure causes the tilt state and the vibrating motion getting worse, which can be eased by improving the rotational speed, the sealing belt width and the ratio of external and internal sealing belt width.

Originality/value
The proposed research can provide a theoretical reference for the optimizing design of cylinder block/valve plate pair.
Accounting for family and business overlaps
Authors: Quinn Martin , Hiebl Martin , Mazzotta Romilda , Veltri Stefania 
Published: December 2019

Purpose
This paper aims to draw on a family business perspective to explore the historic accounting records of an Italian liquorice juice business. The applicability of the three-circle model of family business systems to such an historic context is examined.

Design/methodology/approach
Using archival records, the Cassa accounting book of the business is studied. Its transactions are examined to distinguish family and business items over the period from 1875 to 1920.

Findings
Through an analysis of the accounting records, the family, ownership and business systems are shown to overlap more than typically expected in a contemporary setting.

Originality/value
Contemporary literature suggests the three-circle model of a family business is relatively static, but it has not been applied to an historic context. This study suggests that the model can be applied in historic studies, but it is not static over time with its elements needing refinement.
What factors determine reviewer credibility?
Authors: Sharma Himanshu , Aggarwal Anu G. 
Published: December 2019

Purpose
The experiential nature of travel and tourism services has popularized the importance of electronic word-of-mouth (EWOM) among potential customers. EWOM has a significant influence on hotel booking intention of customers as they tend to trust EWOM more than the messages spread by marketers. Amid abundant reviews available online, it becomes difficult for travelers to identify the most significant ones. This questions the credibility of reviewers as various online businesses allow reviewers to post their feedback using nickname or email address rather than using real name, photo or other personal information. Therefore, this study aims to determine the factors leading to reviewer credibility.

Design/methodology/approach
The paper proposes an econometric model to determine the variables that affect the reviewer’s credibility in the hospitality and tourism sector. The proposed model uses quantifiable variables of reviewers and reviews to estimate reviewer credibility, defined in terms of proportion of number of helpful votes received by a reviewer to the number of total reviews written by him. This covers both aspects of source credibility i.e. trustworthiness and expertness. The authors have used the data set of TripAdvisor.com to validate the models.

Findings
Regression analysis significantly validated the econometric models proposed here. To check the predictive efficiency of the models, predictive modeling using five commonly used classifiers such as random forest (RF), linear discriminant analysis, k-nearest neighbor, decision tree and support vector machine is performed. RF gave the best accuracy for the overall model.

Practical implications
The findings of this research paper suggest various implications for hoteliers and managers to help retain credible reviewers in the online travel community. This will help them to achieve long term relationships with the clients and increase their trust in the brand.

Originality/value
To the best of authors’ knowledge, this study performs an econometric modeling approach to find determinants of reviewer credibility, not conducted in previous studies. Moreover, the study contracts from earlier works by considering it to be an endogenous variable, rather than an exogenous one.
An international review of arts inclusion policies: lessons for Hong Kong
Authors: Cheung Alvin , Yu Charlotte , Li Queenie , So Helen 
Published: December 2019

Purpose
The purpose of this paper is to review and compare the implementation of “arts inclusion” policies (AIPs) by 14 different public administrative systems around the world. It aims to provide a consolidated source which informs further studies in this field, and to develop a framework to compare AIPs at a global level.

Design/methodology/approach
Using “arts inclusion policy” as the search term, academic journals from a wide spectrum of fields were reviewed. A data set was extracted from the Compendium of Cultural Policies and Trends’ online database which provided real-time information of national cultural policies. Another data set is from the United Nations’ Inequality-adjusted Human Development Index, as the geographic scope of the review – largely focussing on UK, US, Australian, Scandinavian and Asian contexts. Using existing policy-making literature as benchmark, the authors designed and applied a comparative framework dedicated to AIPs which focussed on “policy-making structures” as the main ground of comparison.

Findings
An important finding is that the policy development and implementation of AIPs often underscore inter-sectoral involvement in many public administrations in this study. With policy leadership and financial incentives pivotal to effective AIPs, central governments should take a more concerted leadership role to include AIPs in national inter-sectoral policies, encourage evidence-based research, expand funding and advocate the recognition of the impacts of arts inclusion. It is concluded that AIPs in western countries remain more developed in targeted scopes and programme diversity compared to those of Asian countries and regions. Continued studies in this field are encouraged.

Originality/value
This review is the first of its kind to include a number of Asian and western countries within its research scope, allowing it to offer a more holistic outlook on the development and implementation of AIPs in different countries and regions. A common critique with all relevant existing literature was usually their lack of concrete comparative grounds, and the present study’s all-encompassing review of literature from across different levels and sectors of respective public administrative systems contribute to a unique and comprehensive perspective in the arts and health discourse.
Saudi neomercantilism in the oil price war
Authors: Mahdi Ahmed Samir 
Published: December 2019

Purpose
The so-called “oil price war” of 2014-2016 took place between several main global oil producers; OPEC (led by Saudi Arabia), Russia and the newcomer; American tight oil or fracking oil. These oil producers were competing against each other over market shares in the global oil market, by maintaining their high oil production rates, even if this led to a decline in oil prices and a reduction in revenues from oil sales. As energy politics need more coverage in International Political Economy (IPE) theory, this paper aims to argue that Saudi Arabia's policies during the oil price war of 2014-2016 reflected a policy of neomercantilism, which is the IPE equivalent of the school of realism in International Relations (IR).

Design/methodology/approach
This paper tests for neomercantilism by testing three of its main definitional components. The first definitional component is that the state, as the political authority, intervenes in the economic decisions. The second component is the primacy of the state interests over business corporate profits, or the primacy of political and security considerations over short-term economic and corporate profit considerations. The third is the zero-sum or relative gains nature of dealings between states. Afterwards, this paper tests for neomercantilism in the Saudi policy by examining how each of these definitional components is reflected in the Saudi policy during the oil price war.

Findings
As energy politics need more coverage in International Political Economy (IPE) theory, this paper argues that Saudi Arabia's policies during the oil price war of 2014-2016 reflected a policy of neomercantilism, which is the IPE equivalent of the school of realism in International Relations (IR).

Originality/value
As energy politics need more coverage in International Political Economy (IPE) theory, this paper argues that Saudi Arabia's policies during the oil price war of 2014-2016 reflected a policy of neomercantilism, which is the IPE equivalent of the school of realism in International Relations (IR).
Fused deposition modelling interfacial and interlayer bonding in PLA post-processed parts
Authors: Valerga Puerta Ana P. , Fernandez-Vidal S.R. , Batista Moises , Girot F. 
Published: December 2019

Purpose
This paper aims to study the interfacial and interlayer bonding of Polylactic acid parts manufactured by fused deposition modelling. Different layer thicknesses are analysed in the manufacture of these pieces and the lack of material associated with this parameter is verified. The influence of the immersion of these parts in different solvents is also studied, as they are increasingly used in the improvement of the surface finish. Tomography results are also obtained in which the increase in density of the parts subjected to these treatments is demonstrated.

Design/methodology/approach
The material used in this study is a 1.75-mm diameter polylactic acid (PLA) filament from fused filament fusion world. Monolayer and multilayer samples have been manufactured. The manufactured parts were subjected to solvent immersion for a period of 60 s. The solvents used are chloroform (CHCl3), dichloromethane (CH2Cl2), tetrahydrofuran (C4H8O) and ethyl acetate (C4H8O2). The pieces were then dried for 48 h. The interior of the samples was evaluated by two techniques: microscopy and tomography.

Findings
With this study, it has been observed that the thickness of the layer affects the porosity interfacial to a greater extent than in the interlayer, causing the increase in porosity as this thickness is increased.The impact of different chemical treatments (immersions in different solvents) on the internal quality of the parts has been evaluated. All the solvents analysed soften the surface as they cause the softening of the material and its possible redistribution. In the interior, however, they affect in a lighter way. The retention of solvents in the porosity of the pieces is also checked, especially pronounced in the areas close to the surface. Finally, changes are observed in the density of the pieces, related to the partial crystallization of the samples.

Originality/value
All that has been studied shows that the application of chemical post-processes not only affects the surface texture of the parts, or the less studied mechanical properties, but also affects the interfacial union of the parts in a very different way. This is the first study carried out on this aspect with polylactic acid (PLA) and post-processing methods.
Salt reduction in film‐ripened, semihard Edam cheese
Authors: Hoffmann Wolfgang , Luzzi Giuseppina , Steffens Marco , Clawin‐Rädecker Ingrid , Franz Charles M A P , Fritsche Jan 
Published: December 2019

As a potential measure to improve public health, this study aimed to reduce the sodium (Na) content of film‐ripened, semihard Edam cheese to ≤0.4 g Na/100 g (≤1 g NaCl/100 g), while retaining typical quality and safety characteristics. For this, mineral salt substitutions containing potassium (K) were compared with simple NaCl reduction in brine, alongside an adjustment of starter cultures in an effort to enhance taste. Desired Na and K values were achieved, and microbial quality was not compromised in Na‐reduced Edam after six weeks of ripening. However, all Na‐reduced cheeses tasted bitter and were therefore organoleptically unsatisfactory.
Management of immune checkpoint inhibitor‐related dermatologic adverse events
Authors: Si Xiaoyan , He Chunxia , Zhang Li , Liu Xiaowei , Li Yue , Wang Hanping , Guo Xiaoxiao , Zhou Jiaxin , Duan Lian , Wang Mengzhao , Zhang Li 
Published: December 2019

AbstractImmune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. The unique spectrum of immune‐related adverse events (IrAEs) may occur during treatment. Dermatologic toxicities appear to be one of the most prevalent immunotherapy‐related adverse events. The most common symptoms are maculopapular rash and pruritus. Serious dermatologic toxicities including Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reactions with eosinophilia and systemic symptoms are rare. In this review, we summarize guidelines of management of immunotherapy‐related toxicities, case reports, and proposed treatment recommendation.