bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the antitumor role of B cells in patients with non-small cell lung cancer.
Authors: Bruno Tullia C. 
Published: November 2019

75 Background: The focus of immunotherapy has been on CD8 and CD4 tumor infiltrating lymphocytes (TILs), however, tumor infiltrating B cells (TIL-Bs) have been reported in tertiary lymphoid structures (TLS) with CD4 TILs, and both TIL-Bs and TLS correlate with NSCLC patient survival. While TIL-Bs have been identified in NSCLC patients, their function in the tumor microenvironment has been understudied with no focus on their role as antigen presenting cells (APCs) and their influence on CD8 and CD4 TILs. We hypothesize that TIL-Bs help generate potent, long-term immune responses against cancer by presenting tumor antigens to CD4 TILs. Methods: We used freshly isolated B cells from NSCLC patient tumor and tumor adjacent tissue to determine TIL-B function. We generated a specific in vitro antigen presentation assay to determine APC function and immunoregulation by TIL-Bs, and we correlated our findings with tumor-free survival. Results: We observed that the total number of B cells at the site of the tumor versus the tumor-adjacent tissue was increased compared to other immune subsets. Further, we observed three types of CD4 TIL responses when TIL-Bs presented autologous tumor antigens. There were activated responder CD4 TILs that proliferated when combined with TIL-Bs alone, which indicates stimulation with endogenous tumor antigens. There were antigen-associated responders that required exogenous autologous tumor lysate to elicit a CD4 TIL response, and there were patient CD4 TILs that did not respond to antigen presentation by TIL-Bs. Within the activated and antigen-associated responders, the TIL-B phenotype influenced the CD4 TIL phenotype; if the TIL-Bs were activated (CD69+CD27+CD21+), the CD4 TILs were T helper (anti-tumor) CD4 T cells and if the TIL-Bs were exhausted (CD69-CD27-CD21-), the CD4 TILs were T regulatory cells (pro-tumor). These data suggest that TIL-Bs influence the phenotype and function of CD4 TILs in NSCLC patient tumors. Conclusions: In conclusion, determining if TIL-Bs are activated or exhausted in NSCLC patients will determine the extent of their anti-tumor function in cancer. Ultimately, results from this study will help predict how to target TIL-B functions in future immunotherapies for NSCLC patients.
Model-based meta-analysis of safety for immune checkpoint inhibitor combinations and monotherapy.
Authors: Abdallah Kald , Shulgin Boris , Peskov Kirill , Kosinsky Yuri , Vergara-Silva Andrea , Helmlinger Gabriel , Chu Lulu , Masson Eric 
Published: November 2019

89 Background: Immune checkpoint inhibitors (ICIs) have shown efficacy across multiple cancer types; however, ICIs are also associated with immune-mediated (im) adverse events (AEs) especially when used in combination. Methods: Published safety data from 35 melanoma and non-small cell lung cancer clinical trials was normalized for drug exposure using drug concentrations at 50% inhibition (IC50). Pharmacokinetic models from FDA, EMEA, and our own model were used to compare AEs across 4 ICIs: anti-PD-1 (nivolumab, pembrolizumab) and anti-CTLA-4 (ipilumumab, tremelimumab). Data was analyzed by ICI target and organ class (ie, GI, skin, liver, lung, and endocrine). To test dependence of AE rate (%) on drug dose dependence (DD) we calculated mean AE rates for low and high halves of the dose range, and used Pearson’s χ2-squared test for statistical significance (SS) ( p< 0.05). Results: We found AEs to be DD for anti-CTLA-4 monotherapies and anti-CTLA-4 + anti-PD-1 combinations, whereas DD was not SS for anti-PD-1 monotherapies (Table). For anti-CTLA-4 drugs DD was SS for GI, hepatic, skin, and endocrine AEs. In combination, there was DD upon anti-CTLA-4, but data were insufficient to confirm SS. For PD-1 drugs there was no significant DD found. Conclusions: For anti-PD-1 therapy, no DD for Grade 3/4 AEs was found across organ classes. However, for anti-CTLA-4 therapies, DD was SS for GI, skin, hepatic, and endocrine im AEs. Although not all data were sufficient to confirm SS, dose intensity of anti-CTLA-4 may be an important determinant of AEs, when co-administered with anti-PD-1. [Table: see text]
Cross-Cultural Validity Study of a Medical Education Leadership Competencies Instrument in Latin American Physicians: A Multinational Study
Authors: Mano Max S. , Gomes Rafaela , Werutsky Gustavo , Barrios Carlos H. , Marta Gustavo Nader , Villarreal-Garza Cynthia , Frasson Antonio Luiz , Sternberg Cinthya , Clara Renan , Simon Sergio D. , Çitaku Fadil , Waldrop Marianne , Violato Claudio , Zillioux Don , Khan Yawar Hayat 
Published: November 2019

PURPOSE Physicians rarely receive formal training in leadership skills. Çitaku and colleagues have identified a set of leadership competencies (LCs) providing validity evidence in North American (NA) and European Union (EU) medical education institutions. We aim to apply this same survey to a sample of Latin American (LA) medical leaders from the oncology community and related areas, compare the results with those of the previous survey, and perform subgroup analyses within the LA cohort. METHODS The survey was sent to nearly 8,000 physicians of participating professional organizations. In addition to the 63 questions, we also collected data on the type of institution, country, specialty, sex, age, years of experience in oncology, and leadership position. RESULTS The 217 LA respondents placed the highest value on task management competencies (91.37% reported these as important or very important v 87.0% of NA/EU respondents; P < .0001), followed by self-management (87.45% of LA respondents v 87.55% of NA/EU respondents; P = not significant [NS]), social responsibility (86.83% of LA respondents v 87.48% of NA/EU respondents; P = NS), innovation (86.69% of LA respondents v 85.31% of NA/EU respondents; P = NS), and leading others (83.31% of LA respondents v 84.71% of NA/EU respondents; P = NS). Social responsibility, which was first in importance in the NA/EU survey, was only third in the LA survey. Subgroup analyses showed significant variations in the ratings of specific LCs within the LA population. CONCLUSION LCs valued by LA leaders somewhat differ from those valued by their NA and EU counterparts, implying that cultural aspects might influence the perception of desired LCs. We also detected variations in the responses within the LA population. Our data indicate that current physician leadership training programs should be tailored to suit specific needs and cultural aspects of each region. Further validity studies of this instrument with other samples and cultures are warranted.
Reproductive Injustice and the Politics of Trans Future in France
Authors: Fiorilli Olivia 
Published: November 2019

Abstract
This article tackles the issue of trans futures through a critical discussion of trans reproductive injustice in France. Most notably, it focuses on one of its many facets: the cisnormative administration of publicly funded gamete cryo-preservation. For a long time trans people in France have been excluded from the possibility of banking their gametes. Only recently the situation is starting to change, but the right of all trans people to cryo-preserve their gametes is far from being fully recognized. The first part of the article traces the genealogy of the exclusion of trans people from gamete cryo-preservation by offering some historical background of the necropolitical governance of trans reproduction in France. The second part explores in detail a public controversy over trans gamete cryo-preservation that emerged in 2013. Through a close reading of this controversy, the article tackles the discursive and material underpinnings of this cisnormative regulation of gamete cryo-preservation.
“I Sexually Identify as an Attack Helicopter”
Authors: Shalloe Harper 
Published: November 2019

Abstract
This article jumps off and theorizes out from the viral meme “I Sexually Identify as an Attack Helicopter” to think trans as a cut across diagrams of control and counterinsurgency. Terming the set of digital and discursive technologies for capturing the threat of trans potentiality the “biopolitics of identification,” it traces spectral appearances of trans as a contrivance for violence through lived and imagined scenes of surveillance and security.
Frequencies of gastrointestinal parasites among students of primary school in Al Kalakla Locality, Khartoum State, Sudan: a cross-sectional study
Authors: Abdalazim Hassan Hala , Abd Alla Ahmed Bakheet , Elfaki Tayseer Elamin Mohamed , Saad Mohammed Baha Eldin Ahmed 
Published: November 2019

Background:Intestinal parasite spread in tropical countries is especially common among primary school students. This study aimed to determine the frequencies of the intestinal parasite in Alkalakla locality, Khartoum state.Methods:This study was conducted in school students in Al-kalakla locality in Khartoum state from period between 20th December 2016 to 5th May 2017. Stool samples were collected from 134 randomly selected students, of whom 67 were males and 67 were females. All samples were examined using the wet preparation technique, formal ether concentration technique and saturated sugar floatation technique.Results:The frequency of intestinal parasites was 35.5% overall in the students examined; females were more affected than males (38.8% and 32.8%, respectively). The more affected age groups were 12-14 years followed by 9-11 and 6-8 years old (53.8%, 36.3% and 26.4% respectively). The least frequent intestinal parasite wasTaeniaspp. (1.5%) followed byGiardia lamblia(3.7%),Schistosoma mansoniandAscaris lumbricoides(5.2% each),Entamoeba coli(7.5%),Hymenolepis nana(10.4%), andEntamoeba histolytica(16.4%). In total, 20.9% were infected with single parasite while 14.9% were infected with more than one parasite. The frequency of parasite by formal ether concentration method was 35.8 %, by wet preparation method was 17.9 % and by the saturated sugar flotation method was 16.4%.Conclusion:Our data showed that intestinal parasites were common in school students; however, females were more affected than males and the 12-14-years age group was the most affected age group. The formal ether concentration method was the best method for detecting of intestinal parasite.
Relationship and career challenges faced by people infected with HIV in Malaysia
Authors: Tuan Abdullah Tuan Norbalkish , Mat Min Ruhani , Hossain Mosharaf , Abdullah Siti Salina 
Published: November 2019

Background: This study was completed at two general hospitals in Malaysia that provide treatment for HIV patients. The aim of the study was to explore the experiences of people infected with HIV (PIWH) and how they cope with HIV. Methods: This qualitative study was based on a social constructivist and grounded theory approach. A total of 12 PIWH were selected by purposive sampling, all of whom participated in semi-structured and audio-recorded interviews, which were supported with non-participant observations and diary entries on three occasions for each participant. The interviews and diaries were transcribed and analysed using the grounded theory approach, which was assisted by utilizing NVIVO-8 to identify the themes related to the experiences of the participants. Results: PIWH experienced challenges related to their career and relationships with family and others. These challenges led to difficulties in gaining employment and career development, as well as feelings of denial, being uncomfortable, rejection, and labelling. They found that their lives were totally and dramatically changed after being tested positive for HIV. Conclusions: Among PIWH, HIV impacted relationships with significant others and career development. The absence of support and acceptance from significant others affected the ability of PIWH to cope with their daily challenges. The results of this study have implications for policymakers in terms of gaining sufficient knowledge and awareness to provide prevention programmes for HIV/AIDS.
Mental health of Warsaw middle school students. Mokotow Study 2004–2016
Authors: Bobrowski Krzysztof , Ostaszewski Krzysztof , Pisarska Agnieszka 
Published: November 2019

Cel pracyCelem było oszacowanie rozpowszechnienia zaburzeń zdrowia psychicznego w części populacji młodzieży ..................................oraz określenie trendów w latach 2004 – 2016.MetodaPowtarzane co cztery lata badania przekrojowe obejmowały uczniów trzecich klas gimnazjalnych, ............................... Stosowano losowy dobór klas do próby z poprawką na dobór klastrowy. Audytoryjne badania ankietowe prowadzono w trakcie lekcji szkolnych. Wskaźniki opisywały problemy: 1/ internalizacyjne (symptomy depresji wg skróconej skali CES-D oraz inne zaburzenia emocjonalne, wg subiektywnej oceny badanych); 2/ eksternalizacyjne – współwystępowanie dwóch spośród trzech typów zachowań (nadużywanie substancji psychoaktywnych, sprawstwo przemocy, wykroczenia); 3/ mieszane.WynikiW 2016 roku 42% młodzieży przejawiało symptomy zaburzeń zdrowia psychicznego. Problemy te częściej dotykały dziewcząt (48%) niż chłopców (36%). W latach 2008 – 2016 istotnie wzrósł odsetek młodzieży z problemami internalizacyjnymi. Przyczynił się do tego wzrost rozpowszechnienia symptomów depresji. Jednocześnie odnotowano znaczący spadek odsetka młodzieży z problemami eksternalizacyjnymi. Było to pochodną ograniczenia nadużywania substancji psychoaktywnych oraz ograniczenia sprawstwa przemocy.WnioskiNarastanie problemów internalizacyjnych, ryzyka depresji wśród nastolatków oraz rozpowszechnienia innych problemów emocjonalnych, sugeruje pilną potrzebę opracowania lub adaptacji skutecznych programów profilaktycznych oraz poszerzenia dostępności oferty pomocy psychologicznej i psychiatrycznej dla młodzieży.
Parodontoprotective action of oral applications of soy isoflavons in rats after orthodontic operation on the background of experimental diabetes mellitus
Authors: Azari Mohammed Ali Mehrdad , Morozov A. L. 
Published: November 2019

Background. To determine the periodontoprotective effect of soy isoflavones in rats after orthodontic surgery on the background of diabetes mellitus.Methods. In rats, type 1 diabetes was reproduced with aloxane (intraperitoneally at a dose of 100 mg / kg once). From day 12, rats were fitted with orthodontic springs. One of these groups of rats received oral gel applications with soy isoflavones from the first day of the experiment at a dose of 0.5 ml daily for 34 days. The activity of elastase, catalase, urease, lysozyme and the content of malondialdehyde (MDA) were determined in the gum. In the alveolar process of the lower jaw, the activity of alkaline (alkaline phosphatase) and acid (APH) phosphatases, the content of calcium and protein were determined. The antioxidant-prooxidant index (API) was calculated by the ratio of catalase activity and MDA content, the degree of dysbiosis was calculated by the ratio of the relative activities of urease and lysozyme, the mineralizing index (MI) was calculated by the ratio of alkaline phosphatase and APH activity, and the degree of mineralization (DM) was calculated by the ratio of calcium and protein.Results. In rats with diabetes mellitus, the level of elastase, MDA, urease and the degree of dysbiosis increased with a decrease in the API index and lysozyme activity. Orthodontic surgery showed a certain tendency to normalize these parameters, while the application of a gel containing soy isoflavones completely normalized all indicators. In the bone tissue of periodontium in rats with diabetes mellitus, the activity of alkaline phosphatase and MI decreased, but the activity of APH increased. Orthodontic surgery significantly increased the activity of alkaline phosphatase, slightly changing the activity of APH and the index of API. Application of the gel with isoflavones completely normalized the activity of phosphatases, MI and significantly increased the degree of mineralization of bone tissue.Conclusion. Rats with type 1 diabetes develop periodontitis. Orthodontic surgery does not exacerbate the pathological condition, showing even a slight tendency to normalize. Oral applications of a gel containing soy isoflavones have a periodontoprotective effect, normalizing all biochemical parameters of the gums and bone periodontal tissue.
2019 Topical Meeting on Optical Interference Coatings: Manufacturing Problem Contest [invited]
Authors: Poitras Daniel , Li Li , Jacobson Michael R. , Cooksey Catherine C. 
Published: November 2019

For the seventh Manufacturing Problem Contest, participants were
challenged to fabricate an optical filter with transmittance specified
for

s

-polarization at two incident angles:
10° and 50° from 400 nm to 1100 nm. The problem required that
contestants be equally versed in the design, deposition, and
measurement of optical filters in order to achieve good results. Eight
teams from five different countries participated in the contest using
various deposition techniques. The fabricated filters had a total
thickness between 8.2 µm and 17.6 µm and a total number of layers from
74 to 255, which were deposited onto one or both sides of the
substrate. The performances of the filters were measured by two
independent laboratories. The evaluation results were presented at the
Topical Meeting on Optical Interference Coatings conference held in
Santa Ana Pueblo, New Mexico, in June 2019.
Recognizing voice and redistributing power: Community theatre with refugees and asylum seekers in Leeds
Authors: Berelson Keziah , Cook Tamsin 
Published: November 2019

Abstract
This article analyses the experience of creating Women of Power (2018) with a diverse group of refugees and asylum seekers in Leeds. Using the normative framework of a dialogic continuum of micro and macro dramaturgies to guide the analysis, the risks and tensions present in several forms of theatre facilitation are considered. The article examines the complexities of critical reflection and language in relation to creating theatre and draws on Nancy Fraser's analysis of social injustice to consider the position of the facilitator when working with migrant populations. The article contends that an effective way to create an engaging aesthetic and to work as 'redistributors' of privilege may be to offer sustainable, dramatic and pragmatic structures for participants to add their voices to.
The Foreigner – Unknown Unlabelled Unexpected
Authors: Viora Angela 
Published: November 2019

Abstract
The open-ended durational performance The Foreigner is a personal response to the migration question currently involving Europe, Africa and the Middle East. The work explores and questions notions of identity and territoriality, reality and virtuality, through the anonymity and vulnerability of the artist, and the active participation of the audience in the performance process. The artist's body worked as a mirror that reflected personal ideas, constructs, and emotions of the visitors, who experience and interpret the image of The Foreigner according to their personal histories and past experiences. The result is a multiplicity of perspectives on migration and beyond.
STUDI TENTANG JENIS KRUSTASEA YANG HIDUP DI KARANG BATU DAN PERANANNYA DALAM EKOSISTEM TERUMBU KARANG
Authors: Pratiwi Rianta 
Published: November 2019

STUDIES ON CRUSTACEANS SPECIES LIVING IN THE CORAL REEF AND THEIR ROLE IN ECOSYSTEM. Crustaceans are one of the most specis invertebrates in coral reefs, comprising approximately 20 % of all invertebrate species. This taxa often found clearly living in coral communities. The order Decapoda is the most common crustaceans observed the coral reefs due to their relatively large size and having bright colours. In addition, decapods contribute in the environmental balance and having important roles in coral reef ecosystem such as defending live coral from predators and helping growth of corals.
Boundary Regularity for p-Harmonic Functions and Solutions of Obstacle Problems on Unbounded Sets in Metric Spaces
Authors: Björn Anders , Hansevi Daniel 
Published: November 2019

Abstract
The theory of boundary regularity for p-harmonic functions is extended to unbounded open sets in complete metric spaces with a doubling measure supporting a p-Poincaré inequality, 1 < p < ∞. The barrier classification of regular boundary points is established, and it is shown that regularity is a local property of the boundary. We also obtain boundary regularity results for solutions of the obstacle problem on open sets, and characterize regularity further in several other ways.
Complex interpolation of the predual of Morrey spaces over measure spaces
Authors: Burenkov Victor I. , Hakim Denny I. , Nakai Eiichi , Sawano Yoshihiro , Sobukawa Takuya , Tararykova Tamara V. 
Published: November 2019

Abstract
We prove that block spaces
defined on

ℝ
n

{\mathbb{R}^{n}}

with an arbitrary Radon measure, which are known to be the preduals of Morrey spaces,
are closed under the first and the second complex interpolation method.
The proof of our main theorem uses the duality theorem in the complex interpolation method,
the complex interpolation of certain closed subspaces of Morrey spaces, a characterization of the preduals of block spaces, and
some formulas related to the Calderón product.
A version of Hake’s theorem for Kurzweil–Henstock integral in terms of variational measure
Authors: Skvortsov Valentin , Tulone Francesco 
Published: November 2019

Abstract
We introduce the notion of variational measure with respect to a derivation basis in a topological measure space and consider a Kurzweil–Henstock-type integral related to this basis. We prove a version of Hake’s theorem in terms of a variational measure.
Ageing of Zirconia Dedicated to Dental Prostheses for Bruxers Part 2: Influence of Heat Treatment for Surface Morphology, Phase Composition and Mechanical Properties
Authors: Nakonieczny Damian S. , Sambok Agata , Antonowicz Magdalena , Basiaga Marcin , Paszenda Zbigniew K. , Krawczyk Cezary , Ziębowicz Bogusław , Lemcke Hubert , Kałużyński Piotr 
Published: November 2019

Abstract
Purpose: This part of the study focuses on the influence of zirconia heat treatment for surface morphology, phase composition and mechanical properties
Methods: Zirconia samples was prepared with ISO 13356:2013 and ISO 14704:2008 recommendations. X-ray diffraction, observations (SEM) and (AFM), microhardness (Olivera & Phara method), and static bending test (4PBT) were taken.
Results: characterization of YSZ and high temperature heat treatment has clearly shown that the aging process influences the change in phase composition of the material, significantly worsening the topography. In turn, re-treatment of the high temperature made after the artificial aging process results in reverse transformation of the desired tetragonal phase, but does not affect the improvement of surface morphology.
Conclusions: The research made it possible to assess the negative impact of the zirconium oxide aging simulation process. Because of the failure to achieve the intended results, it was also proved that the high-temperature re-processing was not appropriate.