bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Antiestrogen‐Bound Estrogen Receptor α Interactomes in Hormone‐Responsive Human Breast Cancer Cell Nuclei
Authors: Gigantino Valerio , Salvati Annamaria , Giurato Giorgio , Palumbo Domenico , Strianese Oriana , Rizzo Francesca , Tarallo Roberta , Nyman Tuula A. , Weisz Alessandro , Nassa Giovanni 
Published: August 2020

AbstractEstrogen receptor alpha (ERα) is a ligand‐inducible transcription factor which mediates estrogen actions in hormone‐responsive tumors and is targeted by effective anticancer therapies based on the ERα antagonist ligands, selective estrogen receptor modulators (such as Tamoxifen/TAM) or disruptors (such as Fulvestrant/ICI). Despite its importance for cancer therapy, including acquired resistance to endocrine therapy, the molecular basis of ERα response to different ligands is not fully known to date. Interaction proteomics shows great potential to identify and characterize molecular mechanisms of disease based on physical and functional protein‐protein interaction networks. Tandem affinity purification coupled to mass spectrometry is applied here for mapping in hormone‐responsive breast cancer cells nuclei, the ERα interactomes, induced by each of the two classes of antiestrogens. The results provide new insights on the molecular bases for antiestrogen‐mediated control of ERα function and reveal new potential ways to overcome endocrine therapy resistance in cancer.
Single‐step deposition of hexamethyldisiloxane surface gradient coatings with a high amplitude of water contact angles over a polyethylene foil
Authors: Malekzad Hediyeh , Gallingani Tommaso , Barletta Federica , Gherardi Matteo , Colombo Vittorio , Duday David 
Published: August 2020

AbstractOne interesting category of nano‐ and micro‐engineered surfaces is surface gradients, which allow the controlled optimization of biointerfaces at a small scale in an extended area length. Plasma coatings offer a large diversity of functionalities at the nanoscale, accompanied by high chemical stability and adhesion on a variety of substrates at ambient temperature. Atmospheric‐pressure plasma‐assisted deposition could be employed for the generation of surface gradients on thermosensitive materials. In this study, a corona plasma jet is used to deposit polydimethylsiloxane/SiO2‐like surface gradients on polyethylene foil by varying the O2 concentration in the discharge during the movement of the plasma source. We obtained, in a single‐step approach, gradient coatings along a length of ∼10 cm, with a gradual variation of both chemistry and surface energy.
Quaternary variations in the structural assembly ofN‐acetylglucosamine‐6‐phosphate deacetylase fromPasteurella multocida
Authors: Manjunath Lavanyaa , Coombes David , Davies James , Dhurandhar Mugdha , Tiwari Vikas R. , Dobson Renwick C. J. , Sowdhamini R. , Ramaswamy S. , Bose Sucharita 
Published: August 2020

AbstractN‐acetylglucosamine 6‐phosphate deacetylase (NagA) catalyzes the conversion ofN‐acetylglucosamine‐6‐phosphate to glucosamine‐6‐phosphate in amino sugar catabolism. This conversion is an essential step in the catabolism of sialic acid in several pathogenic bacteria, includingPasteurella multocida, and thus NagA is identified as a potential drug target. Here, we report the unique structural features of NagA fromP. multocida(PmNagA) resolved to 1.95 Å. PmNagA displays an altered quaternary architecture with unique interface interactions compared to its close homolog, theEscherichia coliNagA (EcNagA). We confirmed that the altered quaternary structure is not a crystallographic artifact using single particle electron cryo‐microscopy. Analysis of the determined crystal structure reveals a set of hot‐spot residues involved in novel interactions at the dimer‐dimer interface. PmNagA binds to one Zn2+ion in the active site and demonstrates kinetic parameters comparable to other bacterial homologs. Kinetic studies reveal that at high substrate concentrations (~10‐fold theKM), the tetrameric PmNagA displays hysteresis similar to its distant neighbor, the dimericStaphylococcus aureusNagA (SaNagA). Our findings provide key information on structural and functional properties of NagA inP. multocidathat could be utilized to design novel antibacterials.
Adverse pregnancy outcomes associated with first‐trimester exposure to angiotensin‐converting enzyme inhibitors or angiotensin II receptor blockers: A systematic review and meta‐analysis
Authors: Buawangpong Nida , Teekachunhatean Supanimit , Koonrungsesomboon Nut 
Published: August 2020

AbstractThis study aimed to determine the effects of prenatal exposure to angiotensin‐converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs), particularly when exposure is limited to the first trimester of pregnancy, on adverse maternal and neonatal outcomes. A systematic search was performed on four databases, that is, PubMed, Scopus, Web of Science, and Cochrane Library, to identify relevant articles published up to December 31, 2019. Included studies were limited to original investigations assessing the association between prenatal exposure to ACEIs/ARBs and adverse pregnancy outcomes. Odds ratios were used as a summary effect measure. Pooled‐effect estimates of each outcome were calculated by the random‐effects meta‐analysis. The main outcomes included overall and specific congenital malformations, low birth weight, miscarriage, elective termination of pregnancy, stillbirth, and preterm delivery. Of 19 included articles involving a total of 4 163 753 pregnant women, 13 studies reported an increased risk of, at least, one adverse pregnancy outcome in pregnant women who were exposed to ACEIs/ARBs. Meta‐analysis revealed a significant association between overall congenital malformations and first trimester‐only exposure to ACEIs/ARBs (OR = 1.94, 95% CI = 1.71‐2.21, P < .0001). Cardiovascular malformations, miscarriage, and stillbirth also provided a significant relation with ACEI/ARB exposure. In conclusion, prenatal exposure to ACEIs/ARBs in the first trimester of pregnancy was found to be associated with an increased risk of adverse pregnancy outcomes. Women of reproductive age should be aware of the potential teratogenic risks of these drugs if they become pregnant.
Relapsing polychondritis with isolated tracheal involvement and airway‐only symptoms
Authors: Wang Sheng‐Yuan , Weng Chia‐Tse , Cheng Lili , Huang Tang‐Hsiu 
Published: August 2020

AbstractRelapsing polychondritis (RP) is a rare autoimmune disorder, characterized by the inflammation of cartilaginous structures and proteoglycan‐rich tissues. Due to its rarity and the notoriously variable presentations, the diagnosis of RP could be challenging. We report an unusual case of RP with isolated tracheal involvement and very non‐specific symptoms of exertional dyspnoea and dry cough. The initial chest radiograph showed long‐segment narrowing of the trachea, and the computed tomography of the chest revealed thickened cartilaginous walls of the trachea, while the posterior membranous portion was spared. The tracheal narrowing was readily observed under bronchoscopy. The patient was treated with oral prednisolone. Although the subsequent course was transiently complicated by an episode of severePneumocystis jiroveciipneumonia with acute respiratory distress syndrome, the patient overall responded well to systemic corticosteroid therapy. No new symptoms developed during a two‐year follow‐up.
Peroxidase‐Mimetic and Fenton‐Like Activities of Molybdenum Oxide Quantum Dots
Authors: Xiao Sai Jin , Wang Li Zhi , Yuan Ming Yue , Huang Xiao Huan , Ding Jian Hua , Zhang Li 
Published: August 2020

AbstractMolybdenum oxide nanomaterials have become a popular nanomaterial while its catalysis behavior especially the bio‐catalysis property is little understood, even though molybdenum has been employed as a key cofactor in several important enzymes in biological system. On the basis of these, the Fenton and peroxidase‐like property of molybdenum oxide quantum dots (MoOx QDs) with mixed valence state was carefully investigated using tetramethylbenzidine (TMB) and methyl orange (MO) as the substrates. The results showed that MoOx QDs not only serve as a Fenton reagent, degrading MO to colorless products, but also exhibit intrinsic peroxidase‐mimetic activity, oxidizing TMB to the oxidized state oxTMB. The catalysis mechanism of MoOx QDs is that MoOx QDs can facilitate the decomposition of H2O2 and a large amount of radicals was generated, leading to MO decomposing and TMB oxidizing subsequently. Inspired by the findings, a visible method was developed for sensitive and selective detection of H2O2 and glucose, and the limit of detection for H2O2 and glucose is 7.75 μM and 8.95 μM (3σ/K), respectively. Moreover, glucose content in human serum samples was successfully determined by the proposed visible method, and the results are consistent well with those obtained by handheld glucose meter, suggesting a high accuracy of the present method.
Synthesis, In Vitro Antiplatelet Activity of 4‐Ethoxy‐isophthalamides
Authors: Zhang Zhi‐hao , Wang Xiao , Wang Chao‐qing , Liu Xiu‐jie 
Published: August 2020

AbstractWith the help of spatial quantitative structure‐activity relationships (QSAR) contour maps obtained by comparative molecular field analysis (CoMFA), a series of 4‐ethoxyisophthalamide compounds were prepared and some of them with higher activity were found. This paper continues the structural design, preparation, spectral confirmation of thirteen new 4‐ethoxyisophthalamide compounds and completes their preliminary screening of activity in response to the following inducers: adenosine diphosphate (ADP) and collagen. Among them, when ADP was used as an inducer, compounds whose activities are higher or close to picotamide, the IC50 value also were calculated and revealed that one compound 16 (IC50 : 0.26 μmol L−1) was more than three times more active than positive control drug picotamide. Meanwhile, cytotoxic effects in vitro of compound 11* and compound 16 on L929 cells were analyzed. The structure‐activity relationship showed that when electron‐withdrawing groups nitro or trifluoromethyl are introduced at the meta‐ or para‐ position of the two side chain benzene rings, it is beneficial on the whole to the improvement of antiplatelet activity.
Zinc(II) acetate Catalyzed Depolymerization of Poly(ethylene terephthalate)
Authors: Hofmann Melanie , Sundermeier Jannis , Alberti Christoph , Enthaler Stephan 
Published: August 2020

AbstractThe depolymerization of plastic waste to valuable chemicals (waste‐to‐chemicals) can be a useful implement for a resource‐efficient economy. In this regard, the selective depolymerization of end‐of‐life poly(ethylene terephthalate) (PET) via zinc(II) acetate‐catalyzed methanolysis was investigated. As low molecular weight products dimethyl terephthalate and ethylene glycol were generated. With the support of microwave heating excellent yields and selectivities were realized and a selection of daily‐used PET goods were depolymerized. The obtained chemicals can be used for the (re)polymerization to new PET. Additionally, the generated dimethyl terephthalate was used as platform chemical for the synthesis of different molecules relevant for polymerization chemistry.
Thermal Behavior of Anhydrous Ascorbic Acid 6‐Palmitate with Trace of Decomposition
Authors: Ogawa Shigesaburo , Hirase Ryuji , Ohishi Tomoyuki , Hara Setsuko , Takahashi Isao 
Published: August 2020

AbstractAscorbic acid 6‐palmitate (AsP) is an industrially utilized antioxidant and amphiphilic lipid, which forms a liquid crystalline (LC) phase. Herein, we describe the basic thermal behavior of AsP under anhydrous condition. Grazing‐incidence wide‐angle X‐ray‐diffraction (GI‐WAXD) measurements using a two‐dimensional detector (2D‐GI‐WAXD) and perpendicularly aligned AsP films, together with thermal analysis, showed that the AsP forms only a lamellar LC phase above its melting point (Tm); however, when the LC phase was cooled to facilitate annealing and recrystallization, crystals (Cr) formed with a low degree of crystallinity. Furthermore, a composite system, consisting of the Cr phase and LC phase of AsP, was obtained upon reheating. These anomalous phenomena were likely caused by trace dimerization and decomposition of AsP at a temperature just above Tm, although thermal decomposition accompanied by weight reduction occurred at a much higher temperature in the isotropic phase (IL). Thus, the basic thermal behavior of AsP, which is essential for its use, was unveiled.
Growth of Highly Active Amorphous RuCu Nanosheets on Cu Nanotubes for the Hydrogen Evolution Reaction in Wide pH Values
Authors: Cao Dong , Wang Jiayi , Xu Haoxiang , Cheng Daojian 
Published: August 2020

AbstractRational design of low‐cost, highly efficient, and stable electrocatalysts for the hydrogen evolution reaction (HER) has attracted wide attention. Herein, 3D RuCu nanocrystals (NCs) are successfully synthesized by a facile wet chemistry method, in which amorphous RuCu nanosheets are directly grown on crystalline Cu nanotubes (NTs). Importantly, the obtained 3D RuCu NCs only need 18 and 73 mV to deliver the current density of 10 mA cm−2 for HER in alkaline and neutral media, respectively. Density functional theory calculations and experiments reveal that the Ru sites on the surface of amorphous nanosheets are the highly active centers for HER. Moreover, this catalyst can expose more surface area for water splitting compared to pure nanosheets because the unique 3D structure can effectively prevent the aggregation of nanosheets. Meanwhile, the interface between amorphous nanosheets and crystalline NTs is essential to boost the HER performance because the amorphous phase with many unsaturated bonds can facilitate adsorption of reactants and crystalline Cu with superior conductivity can promote the transfer of electrons. This work provides a facile method to prepare an original 3D Ru‐based electrocatalyst with highly active HER performance in wide pH values.
Skin‐Like Stretchable Fuel Cell Based on Gold‐Nanowire‐Impregnated Porous Polymer Scaffolds
Authors: Gong Shu , Du Shengrong , Kong Jianfei , Zhai Qingfeng , Lin Fenge , Liu Siyuan , Cameron Neil R. , Cheng Wenlong 
Published: August 2020

AbstractSkin‐like energy devices can be conformally attached to the human body, which are highly desirable to power soft wearable electronics in the future. Here, a skin‐like stretchable fuel cell based on ultrathin gold nanowires (AuNWs) and polymerized high internal phase emulsions (polyHIPEs) scaffolds is demonstrated. The polyHIPEs can offer a high porosity of 80% yet with an overall thickness comparable to human skin. Upon impregnation with electronic inks containing ultrathin (2 nm in diameter) and ultrahigh aspect‐ratio (>10 000) gold nanowires, skin‐like strain‐insensitive stretchable electrodes are successfully fabricated. With such designed strain‐insensitive electrodes, a stretchable fuel cell is fabricated by using AuNWs@polyHIPEs, platinum (Pt)‐modified AuNWs@polyHIPEs, and ethanol as the anode, cathode, and fuel, respectively. The resulting epidermal fuel cell can be patterned and transferred onto skin as “tattoos” yet can offer a high power density of 280 µW cm−2 and a high durability (>90% performance retention under stretching, compression, and twisting). The results presented here demonstrate that this skin‐thin, porous, yet stretchable electrode is essentially multifunctional, simultaneously serving as a current collector, an electrocatalyst, and a fuel host, indicating potential applications to power future soft wearable 2.0 electronics for remote healthcare and soft robotics.
Prediction of pathological response to neo‐adjuvant chemoradiotherapy for oesophageal cancer using vibrational spectroscopy
Authors: Nguyen Thi N. Q. , Maguire Adrian , Mooney Catherine , Jackson Naomi , Lynam‐Lennon Niamh , Weldon Vicki , Muldoon Cian , Maguire Aoife A. , O'Toole D. , Ravi Narayanasamy , Reynolds John V. , O'Sullivan Jacintha , Meade Aidan D. 
Published: August 2020

AbstractIn oesophageal cancer (OC) neo‐adjuvant chemoradiotherapy (neoCRT) is used to debulk tumour size prior to surgery, with a complete pathological response (pCR) observed in approximately ∼30% of patients. Presently no predictive quantitative methodology exists which can predict response, in particular a pCR or major response (MR), in patients prior to therapy.Raman and Fourier transform infrared imaging were performed on OC tissue specimens acquired from 50 patients prior to therapy, to develop a computational model linking spectral data to treatment outcome. Modelling sensitivities and specificities above 85% were achieved using this approach. Parallel in‐vitro studies using an isogenic model of radioresistant OC supplied further insight into OC cell spectral response to ionising radiation where a potential spectral biomarker of radioresistance was observed at 977 cm−1.This work demonstrates that chemical imaging may provide an option for triage of patients prior to neoCRT treatment allowing more precise prescription of treatment.
Biological fixed‐film systems
Authors: Kim Eun‐Sik , Ha Jae‐Hoon , Choi Jeongdong 
Published: August 2020

AbstractThe technical papers published in 2019 regarding wastewater treatment and microbial films were classified into two categories: biofilm and biofilm reactors. The biofilm category includes biofilm formation, biofilm consortia, bacterial signals, biofouling, extracellular polymeric substances, and biofilm membrane bioreactors. The biofilm reactors category provides recent information on rotating biological contactors, fluidized‐bed biofilm reactors, integrated fixed‐film activated sludge, moving‐bed biofilm reactors, packed‐bed biofilm reactors, sequencing biofilm batch reactors, and trickling filters.
Implications of SARS‐CoV‐2 on current and future operation and management of wastewater systems
Authors: Maal‐Bared Rasha , Brisolara Kari , Munakata Naoko , Bibby Kyle , Gerba Charles , Sobsey Mark , Schaefer Scott , Swift Jay , Gary Lee , Sherchan Samendra , Babatola Akin , Bastian Robert , Olabode Lola , Reimers Robert , Rubin Albert 
Published: August 2020

AbstractWhile researchers have acknowledged the potential role of environmental scientists, engineers, and industrial hygienists during this pandemic, the role of the water utility professional is often overlooked. The wastewater sector is critical to public health protection and employs collection and treatment system workers who perform tasks with high potential for exposures to biological agents. While various technical guidances and reports have initially provided direction to the water sector, the rapidly growing body of research publications necessitates the constant review of these papers and data synthesis. This paper presents the latest findings and highlights their implications from a water and wastewater utility operation and management perspective.Practitioner points

Extrapolation from SARS‐CoV‐1 and MERS‐CoV, as well as other surrogates, has helped predicting SARS‐CoV‐2 behavior and risk management.

Data from treated wastewater effluent suggest that current processes are sufficient for SARS‐CoV‐2 control.

Scientific evidence supports the possibility of fecal–oral transmission for SARS‐CoV‐2.

Limited evidence supports the potential survival of infective SARS‐CoV‐2 on surfaces and in aerosols and the efficacy of control measures at reducing transmission.

Protective practices and PPE can protect workers from SARS‐CoV‐2 and other pathogens found in wastewater.
The defluorination of perfluorooctanoic acid by different vacuum ultraviolet systems in the solution
Authors: Li Yuanhao , Lin Qiufeng , Li Cong , Weiguo Zijian , Xu Luo , Zhang Kejia 
Published: August 2020

AbstractPerfluorooctanoic acid (PFOA) is one kind of persistent organic pollutants that is often detected in water. In recent years, the effective degradation technologies of PFOA have attracted widespread attentions. Thus, in this study, the defluorination efficiency of PFOA in different systems (i.e., ultraviolet (UV), vacuum ultraviolet (VUV), vacuum ultraviolet/persulfate (VUV/PS) and vacuum ultraviolet/residual chlorine (VUV/RC)) was evaluated. Moreover, the different impact factors (i.e., the initial concentrations of persulfate and PFOA, temperature, anions, and initial pH values) on PFOA degradation by VUV/PS system were investigated. The results showed that VUV system was more effective than UV system for PFOA defluorination. VUV system combined with persulfate would further enhance the defluorination efficiency while residual chlorine would decrease it. In VUV/PS system, the defluorination efficiency of PFOA was the best as the molar ratio of PFOA and persulfate at 1:60. Moreover, higher temperature, lower initial PFOA concentration, and acid condition were favorable for the defluorination of PFOA. Under the different influence factors, the defluorination efficiency of PFOA fitted well to the first‐order reaction kinetic model. When the temperature was range from 20°C to 40°C, the value of activation energy was 8.73 kJ/mol. Besides, the inhibition effect of three kinds of anions on PFOA defluorination followed the order: > Cl− > .Practitioner points

The defluorination efficiency of perfluorooctanoic acid (PFOA) in water by different VUV systems was compared.

VUV system is more effective than UV system for PFOA defluorination.

Persulfate will enhance the defluorination efficiency by VUV system.

Hypochlorite will decrease the defluorination efficiency by VUV system.
Identification and associated hazards of clandestine drug laboratories
Authors: Norman Keith , Ciesielski Austin L. , Wagner Jarrad R. 
Published: August 2020

AbstractThe production of illicit drugs at clandestine laboratory operations is a world‐wide problem with many associated public health hazards. This review describes many laboratory types that might be encountered by the clandestine laboratory response personnel, describing the materials and processes associated with different clandestine laboratories to aid in awareness and hazard identification. Clandestine laboratories generally create products according to market forces, including the end‐user expectations with regard to product appearance (e.g., as solid or liquid, in powder or tablet formulation) and potency. The clandestine laboratories use different materials, and processes depending on the laboratory's access to precursors, their ability to produce quantities sufficient to meet market demands, and also their ability to circumvent local, national and international laws and regulations. The information presented here is aimed at both laboratory‐based scientists and analysts who have to understand the classical methods for production, which are still used, and consider novel methods using alternative precursors. It is important to be cognizant of the emerging drugs and drug analogues, how these are considered under the law, and how they can be safely collected for analysis. Clandestine laboratory responders must consider the information presented here from the perspective of the risks associated with the drugs, precursors, waste materials and equipment. As clandestine laboratories and drug markets are constantly evolving, responders need to consistently pursue ongoing education, research, and collaboration with the constant review and assessment of the emerging drugs and precursors seized during operations and reported on regional and international forums.This article is categorized under:
Forensic Chemistry and Trace Evidence > Controlled and Emerging Drug Compounds
Toxicology > Drug Analysis
Crime Scene Investigation > Crime Scene Examination