bluuebunny/crossref_metadata_2025_split huggingface dataset:
A SIRPα‐Fc fusion protein enhances the antitumor effect of oncolytic adenovirus against ovarian cancer
Authors: Huang Yao , Lv Sai‐qun , Liu Pin‐yi , Ye Zhen‐long , Yang Huan , Li Lin‐fang , Zhu Hai‐li , Wang Ying , Cui Lian‐zhen , Jiang Du‐qing , Hao Fang‐yuan , Xu Hui‐min , Jin Hua‐jun , Qian Qi‐jun 
Published: January 2020

Oncolytic viruses armed with therapeutic transgenes of interest show great potential in cancer immunotherapy. Here, a novel oncolytic adenovirus carrying a signal regulatory protein‐α (SIRPα)‐IgG1 Fc fusion gene (termed SG635‐SF) was constructed, which could block the CD47 ‘don't eat me’ signal of cancer cells. A strong promoter sequence (CCAU) was chosen to control the expression of the SF fusion protein, and a 5/35 chimeric fiber was utilized to enhance the efficiency of infection. As a result, SG635‐SF was found to specifically proliferate in hTERT‐positive cancer cells and largely increased the abundance of the SF gene. The SF fusion protein was effectively detected, and CD47 was successfully blocked in SK‐OV3 and HO8910 ovarian cancer cells expressing high levels of CD47. Although the ability to induce cell cycle arrest and cell death was comparable to that of the control empty SG635 oncolytic adenovirus in vitro, the antitumor effect of SG635‐SF was significantly superior to that of SG635 in vivo. Furthermore, CD47 was largely blocked and macrophage infiltration distinctly increased in xenograft tissues of SK‐OV3 cells but not in those of CD47‐negative HepG2 cells, indicating that the enhanced antitumor effect of SG635‐SF was CD47‐dependent. Collectively, these findings highlight a potent antitumor effect of SG635‐SF in the treatment of CD47‐positive cancers.
Adaptive estimator‐based formation maneuvering control of nonholonomic mobile robots
Authors: Zou Ying , Wen Changyun , Guan Mingyang 
Published: January 2020

SummaryIn this paper, the formation maneuvering control problem for a group of nonholonomic mobile robots with the objective of having a desired formation shape described by distances between pairs of robots and an overall maneuvering velocity is studied. The desired maneuvering velocity, which can be constant or time‐varying, is only known to a set of agents. A control scheme consisting of an adaptive estimator and a modified gradient control law is proposed to solve this problem. The adaptive estimator is designed to estimate the desired maneuvering velocity in either constant or time‐varying situation. Utilizing the estimated velocity, a modified gradient control law is designed based on the nonholonomic kinematic model so that the objective is achieved. Local asymptotic convergence of the overall system is guaranteed by choosing appropriate control parameters. The effectiveness of the proposed control scheme is demonstrated through simulation results.
Polymyxin B‐Polysaccharide Polyion Nanocomplex with Improved Biocompatibility and Unaffected Antibacterial Activity for Acute Lung Infection Management
Authors: Chai Mengying , Gao Yifan , Liu Jun , Deng Yongyan , Hu Dengfeng , Jin Qiao , Ji Jian 
Published: January 2020

AbstractThe decade‐old antibiotic, polymyxin B (PMB), is regarded as the last line defense against gram‐negative “superbug.” However, the serious nephrotoxicity and neurotoxicity strongly obstruct further application of this highly effective antibiotic. Herein, a charge switchable polyion nanocomplex exhibiting pH‐sensitive property is proposed to deliver PMB which is expected to improve the biosafety of PMB on the premise of retaining excellent antibacterial activity. The polyion nanocomplex is prepared through electrostatic interaction of positively charged PMB and negatively charged 2,3‐dimethyl maleic anhydride (DA) grafted chitoligosaccharide (CS). The negative charge of CS‐DA will convert to positive due to the hydrolysis of amide bonds in acidic infectious environment, leading to the disassembly of CS‐DA/PMB nanocomplex and release of PMB. CS‐DA/PMB nanocomplex does not show significant toxicity to mammalian cells while retaining excellent bactericidal capability equivalent to free PMB. The nephrotoxicity and neurotoxicity of CS‐DA/PMB dramatically decrease compared to free PMB. Moreover, CS‐DA/PMB nanocomplex exhibits superior bactericidal activity against Pseudomonas aeruginosa in an acute lung infection mouse model. The pH‐sensitive polyion nanocomplexes may provide a new way to reduce the side effects of highly toxic antibiotics without reducing their intrinsic antibacterial activity, which is the key factor to achieve extensive in vivo clinical applications.
Factors driving olfactory loss in patients with chronic rhinosinusitis: a case control study
Authors: Schlosser Rodney J. , Smith Timothy L. , Mace Jess C. , Alt Jeremiah , Beswick Daniel M. , Mattos Jose L. , Payne Spencer , Ramakrishnan Vijay R. , Soler Zachary M 
Published: January 2020

BackgroundOlfactory dysfunction (OD) in chronic rhinosinusitis (CRS) is common. It is likely that numerous factors such as sex, race, age, allergies, asthma, smoking, and other comorbidities play a role in CRS‐related OD. In order to determine which aspects of OD are due solely to CRS and which are associated with other confounders, control populations are needed to allow appropriate risk assessments.MethodsProspective, multi‐institutional enrollment of patients with CRS and control subjects without CRS was performed. Demographic information, comorbidities, and olfactory testing (Sniffin’ Sticks) of threshold (T), discrimination (D), and identification (I) scores (TDI) was collected.ResultsA total of 224 patients with CRS and 164 control subjects were enrolled. Olfaction was worse in CRS patients compared to controls (mean ± standard deviation (SD) TDI = 22.4 ± 9.5 vs 28.8 ± 7.0, respectively, p < 0.001). Only 27% of CRS patients were normosmic compared to 49% of controls (p < 0.001). When stratifying by nasal polyp (NP) status, CRSwNP patients had significant impairments in TDI, T, D, and I compared to controls with mean differences of 11.2, 3.3, 3.5, and 4.4 points, respectively (all p < 0.001). In contrast, CRSsNP patients only had impaired T when compared to controls with a mean difference of 2.2 points (p < 0.001). Multivariate modeling of TDI scoring showed that OD was driven by polyps, asthma, diabetes, and age. CRSsNP was not independently associated with worse TDI scores.ConclusionOD in CRS patients is multifactorial. Independent drivers appear to be polyp status, asthma, diabetes, and age. OD in patients with CRSsNP is similar to controls with the exception of impaired thresholds.
Developing a cancer‐specific trigger tool to identify treatment‐related adverse events using administrative data
Authors: Weingart Saul N. , Nelson Jason , Koethe Benjamin , Yaghi Omar , Dunning Stephan , Feldman Albert , Kent David M. , Lipitz‐Snyderman Allison 
Published: January 2020

AbstractBackgroundAs there are few validated tools to identify treatment‐related adverse events across cancer care settings, we sought to develop oncology‐specific “triggers” to flag potential adverse events among cancer patients using claims data.Methods322 887 adult patients undergoing an initial course of cancer‐directed therapy for breast, colorectal, lung, or prostate cancer from 2008 to 2014 were drawn from a large commercial claims database. We defined 16 oncology‐specific triggers using diagnosis and procedure codes. To distinguish treatment‐related complications from comorbidities, we required a logical and temporal relationship between a treatment and the associated trigger. We tabulated the prevalence of triggers by cancer type and metastatic status during 1‐year of follow‐up, and examined cancer trigger risk factors.ResultsCancer‐specific trigger events affected 19% of patients over the initial treatment year. The trigger burden varied by disease and metastatic status, from 6% of patients with nonmetastatic prostate cancer to 41% and 50% of those with metastatic colorectal and lung cancers, respectively. The most prevalent triggers were abnormal serum bicarbonate, blood transfusion, non‐contrast chest CT scan following radiation therapy, and hypoxemia. Among patients with metastatic disease, 10% had one trigger event and 29% had two or more. Triggers were more common among older patients, women, non‐whites, patients with low family incomes, and those without a college education.ConclusionsOncology‐specific triggers offer a promising method for identifying potential patient safety events among patients across cancer care settings.
Interdisciplinary identification of the skeletal remains of Catherine Roberts‐Davies, The first Welsh settler death in Patagonia, Argentina in 1865
Authors: Dahinten Silvia , Otero Julieta Gómez , Suby Jorge , Coronato Fernando , Vullo Carlos 
Published: January 2020

AbstractIn 1995, an almost complete human skeleton was found in Punta Cuevas, in the southern coast of Puerto Madryn, Chubut, Argentina. The burial traits and the associated objects suggested the skeleton might belong to Mrs. Catherine Roberts‐Davies, a middle‐aged woman who was the first dead person among the first group of 163 Welsh settlers that set sail on May 28, 1865, from Liverpool to Bahía Nueva, in Argentinian Patagonia. The aim of this paper is to present the interdisciplinary studies conducted between 1995 and 2016 in order to identify these remains and to explore the possible causes of death. The age at death of the skeleton was estimated between 25 and 40 years old and sexed as female. The analyses of mtDNA haplogroup resulted in K2a, which is highly frequent in European populations. An ascendant maternal genealogy of Mrs. Roberts‐Davies was reconstructed, based on documentary sources. After this genealogical research, a living descendant, who currently lives in Wales, was found. An mtDNA analysis of control region 16024‐576 was compared among samples taken from the unknown skeleton and the descendant. The results confirmed that the skeleton found in Punta Cuevas belongs to Mrs. Catherine Roberts‐Davies. With respect to the cause of death, according to two historical medical reports, Mrs. Roberts‐Davies died from “black fever” (i.e., visceral leishmaniasis) or scurvy. Skeletal evidence suggests that she could have suffered from scurvy as a consequence of the harsh conditions of living during the trip from Liverpool and the first days after the arrival to Patagonia.
An effective surface modification of UHMWPE fiber for improving the interfacial adhesion of epoxy resin composites
Authors: Wang Shicheng , Ma Jinyang , Feng Xia , Cheng Jinxue , Ma Xiao , Zhao Yiping , Chen Li 
Published: January 2020

AbstractUltra high molecular weight polyethylene (UHMWPE) fiber composite was reinforced by coating a functional layer on the surface of the UHMWPE fiber to improve interfacial adhesion between the fiber and the resin matrix. In this work, tannic acid (TA)‐Na+ composite modified UHMWPE fiber was used to improve moisture wettability and adhesion between the fiber and the resin. This approach had the advantages of being green, sustainable, lossless, low‐cost, and industrialized. The surface characteristics of UHMWPE fiber were investigated by Fourier transform infrared spectroscopy, X‐ray photoelectron spectroscopy, and scanning electron microscopy. The results show that the TA coating can improve the surface roughness, wettability, and adhesion of UHMWPE fiber, thereby improving the interface properties between fiber and resin. The tensile strength of interfacial shear strength and macro‐composites of TA coating UHMWPE fiber increased by 43.3% and 28%, respectively.
Misleading signals in joint schemes for the mean vector and covariance matrix
Authors: Cabral Morais Manuel , Schmid Wolfgang , Ferreira Ramos Patrícia , Lazariv Taras , Pacheco António 
Published: January 2020

AbstractIn multivariate statistical process control, it is recommendable to run two individual charts: one for the process mean vector and another one for the covariance matrix. The resulting joint scheme provides a way to satisfy Shewhart's dictum that proper process control implies monitoring both process location and spread.The multivariate quality characteristic is deemed to be out of control whenever a signal is triggered by either individual chart of the joint scheme. Consequently, a shift in the mean vector can be misinterpreted as a shift in the covariance matrix and vice versa. Compelling results are provided to give the quality control practitioner an idea of how joint schemes for the mean vector and covariance matrix are prone to trigger misleading signals that will likely lead to a incorrect diagnostic of which parameter has changed.
Scattering of compact oscillons
Authors: Hahne F. M. , Klimas P. , Streibel J. S. , Zakrzewski W. J. 
Published: January 2020

Abstract

We study various aspects of the scattering of generalized compact oscillons in the signum-Gordon model in (1+1) dimensions. Using covariance of the model we construct traveling oscillons and study their interactions and the dependence of these interactions on the oscillons’ initial velocities and their relative phases. The scattering processes transform the two incoming oscillons into two outgoing ones and lead to the generation of extra oscillons which appear in the form of jet-like cascades. Such cascades vanish for some values of free parameters and the scattering processes, even though our model is non-integrable, resemble typical scattering processes normally observed for integrable or quasi-integrable models.
Occasionally, in the intermediate stage of the process, we have seen the emission of shock waves and we have noticed that, in general, outgoing oscillons have been more involved in their emission than the initial ones i.e. they have a border in the form of curved worldlines.
The results of our studies of the scattering of oscillons suggest that the radiation of the signum-Gordon model has a fractal-like nature.
There is more to memory than recollection and familiarity
Authors: Kihlstrom John F. 
Published: January 2020

Abstract
Theoretical models of memory retrieval have focused on processes of recollection and familiarity. Research suggests that there are still other processes involved in memory reconstruction, leading to experiences of knowing and inferring the past. Understanding these experiences, and the cognitive processes that give rise to them, seems likely to further expand our understanding of the neural substrates of memory.
Two processes are not necessary to understand memory deficits
Authors: Osth Adam F. , Dunn John C. , Heathcote Andrew , Ratcliff Roger 
Published: January 2020

Abstract
Bastin et al. propose a dual-process model to understand memory deficits. However, results from state-trace analysis have suggested a single underlying variable in behavioral and neural data. We advocate the usage of unidimensional models that are supported by data and have been successful in understanding memory deficits and in linking to neural data.
The integrative memory model is detailed, but skimps on false memories and development
Authors: Bodner Glen E. , Bernstein Daniel M. 
Published: January 2020

Abstract
The integrative memory model combines five core memory systems with an attributional system. We agree with Bastin et al. that this melding is the most novel aspect of the model. But we await further evidence that the model's substantial complexity informs our understanding of false memories or of the development of recollection and familiarity.
Global matching and fluency attribution in familiarity assessment
Authors: Yang Haopei , Köhler Stefan 
Published: January 2020

Abstract
In the integrative memory model proposed by Bastin et al., familiarity is thought to arise from attribution of fluency signals. We suggest that, from a computational and anatomical perspective, this conceptualization converges with a global-matching account of familiarity assessment. We also argue that consideration of global matching and evidence accumulation in decision making could help further our understanding of the proposed attribution system.
Cutting out the middleman: Separating attributional biases from memory deficits
Authors: Wang Wei-Chun 
Published: January 2020

Abstract
Bastin and colleagues present an integrative model of how recollection- and familiarity-based memories are represented in the brain. While they emphasize the role of attribution mechanisms in shaping memory retrieval, prior work examining implicit memory suggests that memory deficits may be better understood by separating attributional biases from the underlying memory traces.
Impacts of Binning Methods on High‐Latitude Electrodynamic Forcing: Static Versus Boundary‐Oriented Binning Methods
Authors: Zhu Qingyu , Deng Yue , Richmond Arthur , Maute Astrid , Chen Yun‐Ju , Hairston Marc , Kilcommons Liam , Knipp Delores , Redmon Robert , Mitchell Elizabeth 
Published: January 2020

AbstractAn outstanding issue in the general circulation model simulations for Earth's upper atmosphere is the inaccurate estimation of Joule heating, which could be associated with the inaccuracy of empirical models for high‐latitude electrodynamic forcing. The binning methods used to develop those empirical models may contribute to the inaccuracy. Traditionally, data are binned through a static binning approach by using fixed geomagnetic coordinates, in which the dynamic nature of the forcing is not considered and therefore the forcing patterns may be significantly smeared. To avoid the smoothing issue, data can be binned according to some physically important boundaries in the high‐latitude forcing, that is, through a boundary‐oriented binning approach. In this study, we have investigated the sensitivity of high‐latitude forcing patterns to the binning methods by applying both static and boundary‐oriented binning approaches to the electron precipitation and electric potential data from the Defense Meteorological Satellite Program satellites. For this initial study, we have focused on the moderately strong and dominantly southward interplanetary magnetic field conditions. As compared with the static binning results, the boundary‐oriented binning approach can provide a more confined and intense electron precipitation pattern. In addition, the magnitudes of the electric potential and electric field in the boundary‐oriented binning results increase near the convection reversal boundary, leading to a ~11% enhancement of the cross polar cap potential. The forcing patterns obtained from both binning approaches are used to drive the Global Ionosphere and Thermosphere Model to assess the impacts on Joule heating by using different binning patterns. It is found that the hemispheric‐integrated Joule heating in the simulation driven by the boundary‐oriented binning patterns is 18% higher than that driven by the static binning patterns.
The Upper Mantle Structure of Northwestern Canada From Teleseismic Body Wave Tomography
Authors: Estève C. , Audet P. , Schaeffer A.J. , Schutt D. , Aster R.C. , Cubley J. 
Published: January 2020

AbstractThe Northern Canadian Cordillera (NCC) is an actively deforming orogenic belt in northwestern Canada. Geochemical and geophysical data show that the NCC is underlain by a thin and hot lithosphere, in contrast with the adjacent cold and thick cratonic lithosphere to the east. This juxtaposition of cold/hot and thick/thin lithosphere across a narrow transition zone has important implications for regional geodynamics. The recent deployment of USArray Transportable Array and other seismic stations across Alaska, USA, and northwestern Canada allows us to image lithosphere and upper mantle three‐dimensional seismic velocity structure at significantly improved resolution. Our model reveals a broad high‐velocity anomaly across northern Yukon and Northwest Territories, which is interpreted as buried cratonic lithosphere and which we refer to as the Mackenzie craton. Another prominent high‐velocity anomaly is imaged beneath northeastern British Columbia and is interpreted to indicate cratonic lithosphere beneath the Northern Rocky Mountains. These two mechanically strong lithospheric blocks, also suggested by regional magnetic data, are interpreted to buttress the ends of the Mackenzie Mountains fold and thrust belt, guiding intervening cordilleran mantle flow toward the Canadian Shield and controlling the arcuate geometry of the Mackenzie Mountains fold and thrust belt. Both
and
wave models also reveal the signature of a northward dipping, subducting Wrangell slab across the southern region of the Alaska/Yukon border. Strong
and
wave velocity contrasts across the Tintina Fault suggest that it is a lithosphere‐scale shear zone that extends into the upper mantle beneath the NCC and demarcates distinct regions of lithospheric mantle.
Increased Dissolved Organic Carbon Concentrations in Peat‐Fed UK Water Supplies Under Future Climate and Sulfate Deposition Scenarios
Authors: Xu J. , Morris P. J. , Liu J. , Ledesma J. L. J. , Holden J. 
Published: January 2020

AbstractPeatlands are globally‐important terrestrial carbon stores as well as regional sources of potable water supply. Water draining from peatlands is rich in dissolved organic carbon (DOC), which can be problematic for water treatment. However, it is unclear how future climate and sulfate deposition changes may impact DOC in peatland‐derived potable water. The United Kingdom (UK) is a global hotspot that consumes 79% of all potable water derived directly from peatlands. Here, a physically‐based hydrological model and a biogeochemical organic carbon model were used to predict discharge and DOC concentration in nine hotspots of peatland‐derived potable water use in the UK under a range of 21st century climate and sulfate deposition scenarios. These nine catchments supply 72% of all peatland‐derived water consumed in the UK and 57% of the global total, equivalent to the total domestic consumption of over 14 million people. Our simulations indicate that annual discharges will decrease and that mean annual DOC concentrations will increase under all future scenarios (by as much as 53.4% annually for the highest emissions scenario) in all catchments. Large increases (by as much as a factor of 1.6) in DOC concentration in the 2090s over the baseline period are projected for autumn and winter, seasons when DOC concentrations are already high in the baseline datasets such that water treatment works often reach their capacity to cope. The total DOC flux is largely insensitive to future climate change because the projected increase in DOC concentration is mostly counterbalanced by the projected decrease in discharge.
A Data Censoring Approach for Predictive Error Modeling of Flow in Ephemeral Rivers
Authors: Wang Quan J. , Bennett James C. , Robertson David E. , Li Ming 
Published: January 2020

AbstractFlow simulations of ephemeral rivers are often highly uncertain. Therefore, error models that can reliably quantify predictive uncertainty are particularly important. Existing error models are incapable of producing predictive distributions that contain >50% zeros, making them unsuitable for use in highly ephemeral rivers. We propose a new method to produce reliable predictions in highly ephemeral rivers. The method uses data censoring of observed and simulated flow to estimate model parameters by maximum likelihood. Predictive uncertainty is conditioned on the simulation in such a way that it can generate >50% zeros. Our method allows the setting of a censoring threshold above zero. Many conceptual hydrological models can only approach, but never equal, zero. For these hydrological models, we show that setting a censoring threshold slightly above zero is required to produce reliable predictive distributions in highly ephemeral catchments. Our new method allows reliable predictions to be generated even in highly ephemeral catchments.