bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consumption smoothing, risk sharing and financial integration
Authors: Donadelli Michael , Gufler Ivan 
Published: June 2020

AbstractTheories indicate that financial integration should allow economies to better share risk and thus improve consumption smoothing. We construct two widely used price‐based measures of financial integration (i.e., the standard correlation and the adjustedR‐squared) and test whether consumption volatility declines as international equity markets become more integrated. Pooled and panel estimates for three different groups of countries (i.e., G7, G20 and EU) provide no significant evidence of improved consumption smoothing as financial integration rises. This evidence is supported by a battery of robustness checks and holds over time. Taken together, our results suggest that convergence in international equity prices does not necessarily represent the channel through which risk‐sharing opportunities arise or consumption smoothing improves.
Outcome after surgical management of canine insulinoma in 49 cases
Authors: Cleland Nicholas Trevor , Morton John , Delisser Peter James 
Published: June 2020

AbstractCanine insulinoma has historically been associated with a poor prognosis; however, prolonged survival times have recently been reported. Prognostic indicators that are available preoperatively are of limited predictive accuracy, and consensus on post‐operative treatment recommendations is lacking. The objectives of this study were to describe outcomes in dogs with insulinoma treated surgically, and to assess whether selected potential risk factors are strongly associated with outcomes after surgery. Medical records of two institutions were searched for dogs with insulinoma that were treated surgically. Forty‐nine dogs were included. Thirty‐nine dogs (80%) had immediate resolution of hypoglycaemia and 10 (20%) remained persistently hypoglycaemic postoperatively. The median survival time (MST) for all dogs was 561 days. The MST for dogs that had resolution of hypoglycaemia was 746 days. The median of the overall euglycaemic time (times from surgery to first detection of hypoglycaemia at any time point after surgery) for all dogs was 424 days. Forty‐four percent of those that had resolution of hypoglycaemia experienced recurrence of hypoglycaemia by 2 years postoperatively. Pathological stage was a predictor of persistent post‐operative hypoglycaemia which, in turn, was a predictor of survival time. These results show that dogs with insulinoma can have prolonged survival, and that pathological stage is a predictor of outcome.
A Generative Approach for Scheduling Multi-Robot Cooperative Three-Dimensional Printing
Authors: Poudel Laxmi , Zhou Wenchao , Sha Zhenghui 
Published: June 2020

Abstract
Cooperative 3D printing (C3DP) is a novel approach to additive manufacturing, where multiple printhead-carrying mobile robots work cooperatively to print the desired part. The core of C3DP is the chunk-based printing strategy in which the desired part is first split into smaller chunks and then the chunks are assigned to individual robots to print and bond. These robots will work simultaneously in a scheduled sequence to print the entire part. Although promising, C3DP lacks a generative approach that enables automatic chunking and scheduling. In this study, we aim to develop a generative approach that can automatically generate different print schedules for a chunked object by exploring a larger solution space that is often beyond the capability of human cognition. The generative approach contains (1) a random generator of diverse print schedules based on an adjacency matrix that represents a directed dependency tree structure of chunks; (2) a set of geometric constraints against which the randomly generated schedules will be checked for validation, and (3) a printing time evaluator for comparing the performance of all valid schedules. We demonstrate the efficacy of the generative approach using two case studies: a large simple rectangular bar and a miniature folding sport utility vehicle (SUV) with more complicated geometry. This study demonstrates that the generative approach can generate a large number of different print schedules for collision-free C3DP, which cannot be explored solely using human heuristics. This generative approach lays the foundation for building the optimization approach of C3DP scheduling.
Treatment Planning Optimization in Irreversible Electroporation for Complete Ablation of Variously Sized Cervical Tumors: A Numerical Study
Authors: Ding Lujia , Moser Michael , Luo Yigang , Zhang Wenjun , Zhang Bing 
Published: June 2020

Abstract
Irreversible electroporation (IRE), a relatively new energy-based tumor ablation technology, has shown itself in the last decade to be able to safely ablate tumors with favorable clinical outcomes, yet little work has been done on optimizing the IRE protocol to variously sized tumors. Incomplete tumor ablation has been shown to be the main reason leading to the local recurrence and thus treatment failure. The goal of this study was to develop a general optimization approach to optimize the IRE protocol for cervical tumors in different sizes, while minimizing the damage to normal tissues. This kind of approach can lay a foundation for future personalized treatment of IRE. First, a statistical IRE cervical tumor death model was built using previous data in our group. Then, a multi-objective optimization problem model was built, in which the decision variables are five IRE-setting parameters, namely, the pulse strength (U), the length of active tip (H), the number of pulses delivered in one round between a pair of electrodes (A), the distance between electrodes (D), and the number of electrodes (N). The domains of the decision variables were determined based on the clinical experience. Finally, the problem model was solved by using nondominated sorting genetic algorithms II (NSGA-II) algorithm to give respective optimal protocol for three sizes of cervical tumors. Every protocol was assessed by the evaluation criterion established in the study to show the efficacy in a more straightforward way. The results of the study demonstrate this approach can theoretically provide the optimal IRE protocol for different sizes of tumors and may be generalizable to other types, sizes, and locations of tumors.
To Stream or Not to Stream? A Case of Social Media Management Within a Professional Sport Organization
Authors: Wymer Sarah , Naraine Michael L. , Thompson Ashleigh-Jane , Martin Andy J. 
Published: June 2020

This is a fictional case based on the actual management of a social media strategy that occurred in a professional sport organization in Queensland, Australia. The intention of the case is to explore a range of social media management themes such as live streaming, audience reach, fan engagement, and decision making as they apply to a sport organization. The case primarily focuses on social media live streaming (specifically Facebook Live) and aims to provide an understanding of live video posts in comparison with other post types (i.e., photo, video, text, and links). The case develops within the theoretical frameworks of relationship marketing, fan engagement, and social media, and is suitable for students learning about sport marketing, sport sponsorship, promotion and public relations, and other communication courses in sport management. Specifically, students are tasked with developing a range of potential strategies to support the lead character, Michael Battersby, in implementing live streaming within a social media strategy.
The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design
Authors: Dimairo Munyaradzi , Pallmann Philip , Wason James , Todd Susan , Jaki Thomas , Julious Steven A , Mander Adrian P , Weir Christopher J , Koenig Franz , Walton Marc K , Nicholl Jon P , Coates Elizabeth , Biggs Katie , Hamasaki Toshimitsu , Proschan Michael A , Scott John A , Ando Yuki , Hind Daniel , Altman Douglas G 
Published: June 2020

AbstractAdaptive designs (ADs) allow pre-planned changes to an ongoing trial without compromising the validity of conclusions and it is essential to distinguish pre-planned from unplanned changes that may also occur. The reporting of ADs in randomised trials is inconsistent and needs improving. Incompletely reported AD randomised trials are difficult to reproduce and are hard to interpret and synthesise. This consequently hampers their ability to inform practice as well as future research and contributes to research waste. Better transparency and adequate reporting will enable the potential benefits of ADs to be realised.This extension to the Consolidated Standards Of Reporting Trials (CONSORT) 2010 statement was developed to enhance the reporting of randomised AD clinical trials. We developed an Adaptive designs CONSORT Extension (ACE) guideline through a two-stage Delphi process with input from multidisciplinary key stakeholders in clinical trials research in the public and private sectors from 21 countries, followed by a consensus meeting. Members of the CONSORT Group were involved during the development process.The paper presents the ACE checklists for AD randomised trial reports and abstracts, as well as an explanation with examples to aid the application of the guideline. The ACE checklist comprises seven new items, nine modified items, six unchanged items for which additional explanatory text clarifies further considerations for ADs, and 20 unchanged items not requiring further explanatory text. The ACE abstract checklist has one new item, one modified item, one unchanged item with additional explanatory text for ADs, and 15 unchanged items not requiring further explanatory text.The intention is to enhance transparency and improve reporting of AD randomised trials to improve the interpretability of their results and reproducibility of their methods, results and inference. We also hope indirectly to facilitate the much-needed knowledge transfer of innovative trial designs to maximise their potential benefits.
Prospective evaluation of improving fluoroquinolone exposure using centralised therapeutic drug monitoring (TDM) in patients with tuberculosis (PERFECT): a study protocol of a prospective multicentre cohort study
Authors: van den Elsen Simone HJ , Sturkenboom Marieke GG , Akkerman Onno , Barkane Linda , Bruchfeld Judith , Eather Geoffrey , Heysell Scott K , Hurevich Henadz , Kuksa Liga , Kunst Heinke , Kuhlin Johanna , Manika Katerina , Moschos Charalampos , Mpagama Stellah G , Muñoz Torrico Marcela , Skrahina Alena , Sotgiu Giovanni , Tadolini Marina , Tiberi Simon , Volpato Francesca , van der Werf Tjip S , Wilson Malcolm R , Zúñiga Joaquin , Touw Daan J , Migliori Giovanni B , Alffenaar Jan-Willem 
Published: June 2020

IntroductionGlobal multidrug-resistant tuberculosis (MDR-TB) treatment success rates remain suboptimal. Highly active WHO group A drugs moxifloxacin and levofloxacin show intraindividual and interindividual pharmacokinetic variability which can cause low drug exposure. Therefore, therapeutic drug monitoring (TDM) of fluoroquinolones is recommended to personalise the drug dosage, aiming to prevent the development of drug resistance and optimise treatment. However, TDM is considered laborious and expensive, and the clinical benefit in MDR-TB has not been extensively studied. This observational multicentre study aims to determine the feasibility of centralised TDM and to investigate the impact of fluoroquinolone TDM on sputum conversion rates in patients with MDR-TB compared with historical controls.Methods and analysisPatients aged 18 years or older with sputum smear and culture-positive pulmonary MDR-TB will be eligible for inclusion. Patients receiving TDM using a limited sampling strategy (t=0 and t=5 hours) will be matched to historical controls without TDM in a 1:2 ratio. Sample analysis and dosing advice will be performed in a centralised laboratory. Centralised TDM will be considered feasible if >80% of the dosing recommendations are returned within 7 days after sampling and 100% within 14 days. The number of patients who are sputum smear and culture-negative after 2 months of treatment will be determined in the prospective TDM group and will be compared with the control group without TDM to determine the impact of TDM.Ethics and disseminationEthical clearance was obtained by the ethical review committees of the 10 participating hospitals according to local procedures or is pending (online supplementary file 1). Patients will be included after obtaining written informed consent. We aim to publish the study results in a peer-reviewed journal.Trial registration numberClinicalTrials.gov Registry (NCT03409315).
Preoperative opioid use and complications following total joint replacement: a protocol for a systematic review and meta-analysis
Authors: Shadbolt Cade , Gould Daniel , Camacho Ximena , Knight Josh , Rele Siddharth , Thuraisingam Sharmala , Zhang Yuting , Dowsey Michelle M , Choong Peter FM 
Published: June 2020

IntroductionMounting evidence now indicates that preoperative opioid use is associated with an array of complications following total joint replacement (TJR). However, evidence of these risks remains fragmented. A comprehensive and well-integrated understanding of this body of evidence is necessary to appropriately inform treatment decisions, the allocation of limited healthcare resources, and the direction of future clinical research. The proposed systematic review and meta-analysis aims to identify and synthesise the available evidence of an association between opioid use prior to TJR and postoperative complications, categorised by complication type.Methods and analysisWe will search MEDLINE, EMBASE, CINAHL, PsycINFO, and Web of Science from inception to April 2020. Observational and experimental studies that compare preoperative opioid users who have undergone elective TJR to opioid naïve TJR patients will be included. The primary outcomes will be postoperative complications, which will be categorised as either mortality, morbidity, or joint-related complications. The secondary outcomes will be persistent postoperative opioid use, readmission, and length of stay. Individual study quality will be assessed using the relevant NIH–NHLBI study quality assessment tools. Findings will be reported in narrative and tabular form, and, where possible, odds ratios (dichotomous outcomes) or standardised mean differences (continuous outcomes) will be reported with 95% confidence intervals. Where appropriate, random effect meta-analyses will be conducted for each outcome, and heterogeneity will be quantified using the I2 statistic and Cochran’s Q test. This study will be reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Meta-analyses Of Observational Studies in Epidemiology (MOOSE) guidelines.Ethics and disseminationEthics approval will not be required as no primary or private data are being collected. Findings will be disseminated through peer-reviewed publication and presentation at academic conferences.PROSPERO registration numberCRD42020153047.
Sacroiliac joint injections with the guidance of three-dimensional cone beam computed tomography (3D-CBCT) and fluoroscopy fusion
Authors: Oren Nisa Cem , Ali Saad , Mok James , Lu Zheng Feng , Lee Seon-Kyu 
Published: June 2020

BackgroundWe describe our diagnostic sacroiliac joint (SIJ) injection technique under the guidance of three-dimensional cone beam computed tomography (3D-CBCT) fused with real-time fluoroscopy.MethodsA retrospective review of 17 patients (mean age 55.4 (range 40–74) years) who received a total of 23 diagnostic SIJ injections between March 2016 and November 2017 were performed. Pre- and post-procedure pain scores were reviewed from the medical records and then these findings were correlated with which patients were and were not diagnosed with SIJ pain by clinical management. The final diagnosis of SIJ-related pain was made in cases with at least 50% symptomatic improvement following SIJ-specific pain treatments.ResultsSome 87% (n=20/23) of injections achieved more than 50% pain relief after the diagnostic SIJ injection. The final diagnosis of the target SIJ-related pain after follow-up and management was found in 90% (n=18/20) of cases. There were two cases with positive tests diagnosed as non-SIJ pain including one with the diagnosis of femuroacetabular impingement and one with pain related to loosening of knee hardware. The sensitivity, specificity, positive predictive value, and negative predicative value of diagnostic SIJ injections were 100%, 60%, 89%, and 100%, respectively, with a 40% false-positive rate. There were no procedure-related complications.Conclusion3D-CBCT fused with real-time fluoroscopy for SIJ injection is accurate and safe.
Catheter fragment embolism in a dog
Authors: Porato Mathilde , Marolf Vincent , Etienne Anne‐Laure 
Published: June 2020

Catheter fragment embolism is a potential complication of peripheral venous catheterisation. A three‐year‐old male dachshund was treated for a tibial fracture. The anaesthesia, orthopaedic procedure and hospitalisation recovery were uneventful. At the time of venous catheter removal, its breakage was noticed. A catheter tip embolisation was suspected and confirmed in the cephalic vein with radiography and ultrasound. A tourniquet was immediately applied proximally to the elbow. It prevented the catheter tip from further migration and central embolisation. A longitudinal venotomy of the cephalic vein allowed the removal of the fragment. Stitches were removed 10 days later and clinical examination was normal.
Continuum extrapolation of Ward identities in $${{\mathcal {N}}=1}$$ supersymmetric SU(3) Yang–Mills theory
Authors: Ali Sajid , Bergner Georg , Gerber Henning , Montvay Istvan , Münster Gernot , Piemonte Stefano , Scior Philipp 
Published: June 2020

AbstractIn $${\mathcal {N}}=1$$N=1 supersymmetric Yang–Mills theory, regularised on a space-time lattice, in addition to the breaking by the gluino mass term, supersymmetry is broken explicitly by the lattice regulator. In addition to the parameter tuning in the theory, the supersymmetric Ward identities can be used as a tool to investigate lattice artefacts as well as to check whether supersymmetry can be recovered in the chiral and continuum limits. In this paper we present the numerical results of an analysis of the supersymmetric Ward identities for our available gauge ensembles at different values of the inverse gauge coupling $$\beta $$β and of the hopping parameter $$\kappa $$κ. The results clearly indicate that the lattice artefacts vanish in the continuum limit, confirming the restoration of supersymmetry.
SEARCH STRATEGIES FOR ORIENTAL BEAUTY: THREE CASES OF LG HOUSEHOLD AND HEALTHCARE
Authors: KIM JONG-SEOK 
Published: June 2020

This study examines the construction of each search strategy that combines search space, depth and network into innovation. It approaches a search as a problem-discovery process, which occurs during all phases of a problem-solving process. It selects three cases of LG Household and Healthcare’s product and process innovation, which typically occur in the cosmetics industry, where many cosmetic firms have conducted problem discoveries of oriental knowledge for product and process innovation. Knowledge of oriental medicine and fermentation are called, as oriental knowledge is traditionally rooted in Asian culture and practices. Through a qualitative multiple-case study, this study identifies the different combinations of the three components in each search strategy — in terms of core competences. It notices that searches in each innovation are conducted during all phases of each problem-solving process rather than being confined to the initial stage of problem-solving activities. Through discussions of each component, this study reveals that despite the importance of ambidexterity in a search, the value system and absorptive capacity can take an important role in an effective search by properly recognising and evaluating the value of knowledge and turning it into a problem. Secondly, the search depth influences the innovation proceedings and links different pieces of knowledge. Lastly, a search network can facilitate problem discoveries, reduce the risk and uncertainty of each problem formulation and lead to competence building, even though it can be subject to partner availability and strategic compatibility issues.
Bovine Arch and Stroke Laterality
Authors: Matakas Jason D. , Gold Menachem M. , Sterman Jonathan , Haramati Linda B. , Allen Michael T. , Labovitz Daniel , Slasky Shira E. 
Published: June 2020

Background
Left‐hemispheric strokes are more frequent and often have a worse outcome than their right‐hemispheric counterparts. This study aimed to evaluate whether cardioembolic stroke laterality is affected by anatomical characteristics of the aortic arch. We hypothesized that laterality varies between patients with bovine versus standard arch.

Methods and Results

We retrospectively identified 1598 acute cardioembolic strokes in patients with atrial fibrillation from our institutional stroke database (2009–2017). Inclusion criteria were acute anterior circulation ischemic infarct and availability of both arch and brain imaging (magnetic resonance imaging or computed tomography). Alternative causes of stroke and anomalous arch were excluded. Imaging was reviewed for stroke characterization and laterality and arch branching pattern. Bovine arch denotes a common origin of the brachiocephalic trunk and left common carotid artery. Strokes were classified as bilateral (left or right). Univariate analysis was performed using chi‐square tests. The final cohort comprised 615 patients, mean age 77 years (
SD
11.8 years) with 376 women (61%) and 33% white, 30% black, and the remainder mixed/Hispanic. Standard arch (n=424) stroke distribution was left 43.6% (185), right 45.1% (191), and bilateral 11.3% (48). Bovine arch (n=191) stroke distribution was left 51.3% (98), right 35.6% (68), and bilateral 13.1% (25). Bovine arches were associated with more left‐sided strokes compared with standard arches (
P
=0.018). There was an association between black race and bovine arch (
P
=0.0001).

Conclusions
Bovine aortic arch configuration is associated with left hemispheric laterality of cardioembolic stroke. This study enriches the understanding that arch anatomy influences stroke laterality and highlights the need for further research into the causative hemodynamic factors.