bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-temperature friction behavior of amorphous carbon coating in glass molding process
Authors: Li Kangsen , Xu Gang , Wen Xiaobin , Zhou Jun , Gong Feng 
Published: November 2020

AbstractIn the glass molding process, the sticking reaction and fatigue wear between the glass and mold hinder the service life and functional application of the mold at the elevated temperature. To improve the chemical inertness and anti-friction properties of the mold, an amorphous carbon coating was synthesized on the tungsten carbide-cobalt (WC–8Co) substrate by magnetron sputtering. The friction behavior between the glass and carbon coating has a significant influence on the functional protection and service life of the mold. Therefore, the glass ring compression tests were conducted to measure the friction coefficient and friction force of the contact interface between the glass and amorphous carbon coating at the high temperature. Meanwhile, the detailed characterization of the amorphous carbon coating was performed to study the microstructure evolution and surface topography of the amorphous carbon coating during glass molding process by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), Ramon spectroscopy, and atomic force microscope (AFM). The results showed that the amorphous carbon coating exhibited excellent thermal stability, but weak shear friction strength. The friction coefficient between the glass and coating depended on the temperature. Besides, the service life of the coating was governed by the friction force of the contact interface, processing conditions, and composition diffusion. This work provides a better understanding of the application of carbon coatings in the glass molding.
Risk Factors for Surgical Shunting in a Large Cohort with Ischemic Priapism
Authors: Zhao Hanson , Dallas Kai , Masterson John , Lo Eric , Houman Justin , Berdahl Carl , Pevnick Joshua , Anger Jennifer T. 
Published: November 2020

Abstract

Background
Ischemic priapism is treated with a stepwise algorithm, but some patients may benefit from immediate shunt placement.

Aim
To identify risk factors for surgical shunt placement in a large series of patients with ischemic priapism.

Methods
We identified all patients presenting to our institution with ischemic priapism from January 2010 to December 2018. Multivariable was performed to assess risk factors for surgical shunting. Receiver operating characteristic curve analysis (Youden Index) was used to assess which cutoff time for the duration of priapism was most predictive requiring shunting.

Outcomes
We assess risk factors for surgical shunting and what duration of priapism was most predictive of requiring a shunt.

Results
We identified a total of 169 ischemic priapism encounters from 143 unique patients, of which 26 (15%) encounters resulted in a surgical shunt. Patients treated with a shunt had longer priapism durations than those without (median 36 vs 10 hours, P &lt; .001). Independent predictors of a surgical shunt on multivariate logistic regression were the duration of priapism in hours (odds ratio: 1.05, 95% confidence interval: 1.02–1.10; P &lt; .001) and history of prior priapism (odds ratio: 3.15, 95% confidence interval: 1.03–9.60; P = .045). Receiver operating characteristic curve analysis using priapism duration to predict the need for shunt generated an area under curve of 0.83. A duration of 24 hours correlated to a sensitivity of 0.77 and specificity of 0.90.

Clinical Implications
These results can be used to counsel future patients and assist in the decision-making process for providers.

Strengths & Limitations
This is one of the largest series of priapism in the literature. Most (74%) of the priapism were due to intracavernosal injections so the results may not be generalizable to populations with different priapism etiologies.

Conclusion
In this study of 169 priapism encounters, we found that the priapism duration and history of prior priapism were independent predictors of surgical shunt placement. These results can aid urologists in the counseling and decision-making process of these challenging cases.
A Review of the Neurosurgical Management of Brain Metastases During Pregnancy
Authors: Proskynitopoulos Phileas J. , Lam Fred C. , Sharma Sunjay , Young Brett C. , Laviv Yosef , Kasper Ekkehard M. 
Published: November 2020

Abstract:Objective:Patients with pregnancy-associated secondary brain tumors (PASBT) are challenging to manage. Because no guidelines for the management of such patients currently exist, we performed a systematic review of the literature using PRISMA guidelines with a discussion of management from a neurosurgeon’s perspective.Method:Systematic review of the literature using PRISMA guidelines from 1999 to 2018.Results:We identified 301 studies of which 16 publications (22 patients reporting 25 pregnancies, 20 deliveries, 5 early terminations) were suitable for final analysis. The most frequent primary cancers were breast (8/22, 36.36%), skin (6/22, 27.27%), and lung (5/22, 22.73%). Four patients (18.18%) had neurosurgical procedures during their pregnancies. Five patients (22.73%) received neurosurgical resection after their pregnancies. Nine patients (40.91%) received radiation therapy and seven patients (31.82%) received chemotherapy during pregnancy while seven patients (31.82%) received chemotherapy and radiation after pregnancy. There was 1 fetal death (5%) out of 20 healthy deliveries. Five pregnancies (20%) were terminated in the first trimester due to a need for urgent neurosurgical intervention.Conclusion:Management of PASBT remains a challenging issue. Maternal and fetal risks associated with surgical resection and teratogenicity due to adjuvant therapy should be discussed in the context of a multidisciplinary team. Timing of surgery and the use of systemic chemoradiation depends on the gestational age (GA) of the fetus, extent, and control of the mother’s primary and metastatic disease. Guidelines need to be established to help neuro-oncology teams safely and effectively manage this group of patients.
Exponential polynomials with Fatou and non-escaping sets of finite Lebesgue measure
Authors: WOLFF MAREIKE 
Published: November 2020

AbstractWe give conditions ensuring that the Fatou set and the complement of the fast escaping set of an exponential polynomial f both have finite Lebesgue measure. Essentially, these conditions are designed such that

$|f(z)|\ge \exp (|z|^\alpha )$
for some

$\alpha>0$
and all z outside a set of finite Lebesgue measure.
Corruption and the impact of law enforcement: insights from a mixed-methods study in Malawi
Authors: Anders Gerhard , Kanyongolo Fidelis E. , Seim Brigitte 
Published: November 2020

ABSTRACTThe article argues that the impact of law enforcement efforts against corruption deserves more scholarly attention. Drawing on a mixed-methods study from Malawi in southern Africa, where a large-scale law enforcement operation has been investigating and prosecuting those involved in a 2013 corruption scandal known as ‘Cashgate’, the article explores the potential for corruption deterrence from the perspective of government officials in the Malawi civil service. Malawi provides a challenging environment for deterrence due to limited state capacity, weak law enforcement agencies and widespread corruption. Nonetheless, the research findings show that Malawian government officials perceive prosecutions and convictions to deter corruption, both with regards to the law enforcement response to Cashgate specifically and law enforcement efforts in general. The findings from Malawi suggest that law enforcement and criminal justice have the potential to make an important contribution to anti-corruption strategies in Africa and the Global South at large.
Mines in the End Zone: Are there Downsides to Team Performance?
Authors: Mumford Troy V. , Maynard M. Travis 
Published: November 2020

Abstract
Research on teams in organizations tends to focus on understanding the causes of team performance with a focus on how to enjoy the benefits of team success and avoid the negative consequences of team failure. This paper instead asks the question, ‘what are some of the negative consequences of team success?’ A review of the literature on teams is augmented with research from cognitive science, sociology, occupational psychology, and psychology to explore the potential negative long-term consequences of teamwork success. The general topics of groupthink, overconfidence bias, regression to the mean, role overload, and strategy calcification are reviewed while discussing the implications for future research streams and practical team management.
Race, Dehumanization, and the NFL National Anthem Protests
Authors: Utych Stephen M. 
Published: November 2020

AbstractDehumanizing language, or language used to describe human beings as non-human entities, is increasingly prevalent in political life. This dehumanization also occurs frequently in the world of sports. Sports and politics intersected notably in 2016, when Colin Kaepernick of the NFL’s San Francisco 49ers started protesting the national anthem to raise awareness about police violence against African-Americans. Kaepernick’s protests generated considerable vitriol towards him and other protesters, some of which was dehumanizing. In this study, I examine how dehumanizing language used against anthem protesters of different races influences political attitudes. Using experimental data, I find that, when a Black player protesting the national anthem is dehumanized, White citizens are considerably less supportive of the anthem protests and protesters. This effect does not persist when the dehumanized player is White.
Impact of Historical Channel Deepening on Tidal Hydraulics in the Delaware Estuary
Authors: Pareja‐Roman L. Fernando , Chant Robert J. , Sommerfield Christopher K. 
Published: November 2020

AbstractAnthropogenic modifications of estuarine morphology such as navigational channels have changed tidal dynamics in many estuaries. The implications of deepening may include shifts in tidal range, sediment transport, pollutant dispersal, and changes in flood risk, among others. Here, we use a numerical model to study how channel deepening has altered tidal elevation, currents, and energy fluxes in the Delaware, a convergent estuary on the east coast of the United States. Historical (1848) and modern (2014) depth soundings were digitized and gridded for a numerical model of the estuary. Numerical experiments indicate a doubling in tidal range, shifts in the arrival time of high water, and changes in elevation‐velocity phase. A historical increase in the upstream conveyance and transmission of energy is consistent with bigger amplitudes, swifter currents, and more progressive wave dynamics in the navigational channel. Changes in local topography were key in the modulation of tidal energy transmission upstream, especially in the tidal river.
A small natural molecule CADPE kills residual colorectal cancer cells by inhibiting key transcription factors and translation initiation factors
Authors: Zheng Guo-Wan , Tang Ming-Min , Shu Chen-Yan , Xin Wen-Xiu , Zhang Yan-Hua , Chi Bin-Bin , Shi Mu-Ran , Guo Xing , Zhang Zhi-Zhen , Lian Xiao-Yuan 
Published: November 2020

AbstractResidual disease is the major cause for colorectal cancer (CRC) relapse. Herein, we explore whether and how a natural molecule CADPE killed heterogenic populations in a panel of CRC cell lines with KRAS/BRAF mutations that are natively resistant to EGFR- or VEGFR-targeted therapy, without sparing persistent cells, a reservoir of the disease relapse. Results showed that CADPE killed the tumor bulk and residual cells in the panel of CRC cell lines, rapidly inactivated c-Myc, STAT3, and NF-κB, and then decreased the protein levels of key signaling molecules for CRC, such as β-catenin, Notch1, and the nodes of mTOR pathways; eukaryotic translation initiation factors (eIF4F); anti-apoptotic proteins (Bcl-xl, Mcl-1, and survivin); and stemness-supporting molecules (CD133, Bim-1, and VEGF). In terms of mechanism of action, concurrent downregulation of Mcl-1, Bcl-xl, and survivin was necessary for CADPE to kill CRC bulk cells, while additional depletion of CD133 and VEGF proteins was required for killing the residual CRC cells. Moreover, the disabled c-Myc, STAT3, NF-κB, and eIF4F were associated with the broadly decreased levels of anti-apoptosis proteins and pro-stemness proteins. Consistently, CADPE suppressed CRC tumor growth associated with robust apoptosis and depleted levels of c-Myc, STAT3, NF-κB, eIF4F, anti-apoptotic proteins, and pro-stemness proteins. Our findings showed the promise of CADPE for treating CRC and suggested a rational polytherapy that disables c-Myc, STAT3, NF-κB, and eIF4F for killing CRC residual disease.
Unveiling the ups and downs of miR-205 in physiology and cancer: transcriptional and post-transcriptional mechanisms
Authors: Ferrari Elena , Gandellini Paolo 
Published: November 2020

Abstract
miR-205 plays important roles in the physiology of epithelia by regulating a variety of pathways that govern differentiation and morphogenesis. Its aberrant expression is frequently found in human cancers, where it was reported to act either as tumor-suppressor or oncogene depending on the specific tumor context and target genes. miR-205 expression and function in different cell types or processes are the result of the complex balance among transcription, processing and stability of the microRNA. In this review, we summarize the principal mechanisms that regulate miR-205 expression at the transcriptional and post-transcriptional level, with particular focus on the transcriptional relationship with its host gene. Elucidating the mechanisms and factors regulating miR-205 expression in different biological contexts represents a fundamental step for a better understanding of the contribution of such pivotal microRNA to epithelial cell function in physiology and disease, and for the development of modulation strategies for future application in cancer therapy.
HAHmiR.DB: a server platform for high-altitude human miRNA–gene coregulatory networks and associated regulatory circuits
Authors: Khurana Pankaj , Gupta Apoorv , Sugadev Ragumani , Sharma Yogendra Kumar , Kumar Bhuvnesh 
Published: November 2020

AbstractAround 140 million people live in high-altitude (HA) conditions! and even a larger number visit such places for tourism, adventure-seeking or sports training. Rapid ascent to HA can cause severe damage to the body organs and may lead to many fatal disorders. During induction to HA, human body undergoes various physiological, biochemical, hematological and molecular changes to adapt to the extreme environmental conditions. Several literature references hint that gene-expression-regulation and regulatory molecules like miRNAs and transcription factors (TFs) control adaptive responses during HA stress. These biomolecules are known to interact in a complex combinatorial manner to fine-tune the gene expression and help in controlling the molecular responses during this stress and ultimately help in acclimatization. High-Altitude Human miRNA Database (HAHmiR.DB) is a unique, comprehensive and curated collection of miRNAs that have been experimentally validated to be associated with HA stress, their level of expression in different altitudes, fold change, experiment duration, biomarker association, disease and drug association, tissue-specific expression level, Gene Ontology (GO) and Kyoto Encyclopaedia of Gene and Genomes (KEGG) pathway associations. As a server platform, it also uniquely constructs and analyses interactive miRNA–TF–gene coregulatory networks and extracts regulatory circuits/feed-forward loops (FFLs). These regulatory circuits help to offer mechanistic insights into complex regulatory mechanisms during HA stress. The server can also build these regulatory networks between two and more miRNAs of the database and also identify the regulatory circuits from this network. Hence, HAHmiR.DB is the first-of-its-kind database in HA research, which is a reliable platform to explore, compare, analyse and retrieve miRNAs associated with HA stress, their coregulatory networks and FFL regulatory-circuits. HAHmiR.DB is freely accessible at http://www.hahmirdb.in
Myocardial infarction and ventricular fibrillation due to iatrogenic right coronary artery occlusion following tricuspid valve annuloplasty: a case report
Authors: Poon Shi Sum , George Joseph , Obaid Daniel , Kumar Pankaj 
Published: November 2020

Abstract

Background
Iatrogenic right coronary artery (RCA) injury is a rare complication of tricuspid valve annuloplasty. Given that surgical intervention is increasingly favoured for tricuspid regurgitation, it is of great importance to recognize potential complications following tricuspid valve surgery.

Case summary
A 72-year-old man underwent surgical mitral and tricuspid valve repair. The early post-operative course was complicated by recurrent ventricular fibrillation episodes. Due to haemodynamic instability, a re-sternotomy and another cardiopulmonary bypass run were required. The patient subsequently underwent coronary angiography study which confirmed RCA occlusion. The occluded posterior left ventricular (PLV) branch was reopened by balloon angioplasty. However, despite multiple attempts it was not possible to pass a coronary guide wire into the posterior descending artery (PDA). An intravascular ultrasound examination revealed that the ostium of the PDA was compressed by external factors leaving a narrow slit-like appearance with no accessible lumen. Subsequently, a drug-eluting stent was placed into the PLV branch. The PDA was not accessible on repeated re-canalization attempts. The patient later successfully recovered from the right ventricular myocardial infarction.

Discussion
Right coronary artery occlusion should be considered as a differential diagnosis for significant rhythm disturbances and haemodynamic instability in the peri- and post-operative period following tricuspid valve annuloplasty. A low threshold for diagnostic angiography is needed to avoid potential delay in life-saving revascularization.
Overcoming Age-Based Stereotypes to Optimize Cognitive Performance in Older Adults: A Systematic Review of Methodology and Existing Evidence
Authors: Parker Giverny J , Ownsworth Tamara , Haslam Catherine , Shum David H K 
Published: November 2020

Abstract

Background and Objectives
Age-based stereotype threat (ABST) poses serious risks for the cognitive screening of older adults. This review aimed to identify and critically appraise the methodology and existing evidence of studies investigating the use of threat-removal (TR) strategies to overcome the effects of ABST on the cognitive performance of older adults. The types of strategies, their effectiveness in optimizing cognitive performance, and factors influencing their effectiveness were examined.

Research Design and Methods
A systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PsycINFO, PubMed, Embase, Web of Science, and Scopus were searched from January 1, 1995 to November 6, 2019. Two authors independently assessed article eligibility and appraised methodological quality of eligible articles using an adaptation of the Strengthening the Reporting of Observational studies in Epidemiology guidelines. Narrative synthesis was used to summarize results.

Results
Thirty articles, reporting on 36 studies, were eligible and included. Overall, evidence for the effectiveness of TR was mixed and varied according to the explicitness of strategies and comparison conditions used. Studies examining blatant TR strategies, and those using a combination of blatant and subtle TR strategies, provided limited support for their effectiveness in overcoming ABST. However, studies evaluating subtle TR strategies provided preliminary support for their effectiveness in overcoming ABST.

Discussion and Implications
Existing studies provide limited evidence regarding the effectiveness of TR strategies in overcoming ABST due to methodological limitations. Recommendations are made for the design of future studies to differentiate the benefits of TR strategies from the detrimental effects of ABST, thus potentially informing their use in clinical practice.
TrkA mediates effect of novel KIDINS220 mutation in human brain ventriculomegaly
Authors: Jacquemin Valerie , Antoine Mathieu , Duerinckx Sarah , Massart Annick , Desir Julie , Perazzolo Camille , Cassart Marie , Thomas Dominique , Segers Valérie , Lecomte Sophie , Abramowicz Marc , Pirson Isabelle 
Published: November 2020

Abstract
Congenital hydrocephalus is a potentially devastating, highly heterogeneous condition whose genetic subset remains incompletely known. We here report a consanguineous family where three fetuses presented with brain ventriculomegaly and limb contractures and shared a very rare homozygous variant of KIDINS220, consisting of an in-frame deletion of three amino acids adjacent to the fourth transmembrane domain. Fetal brain imaging and autopsy showed major ventriculomegaly, reduced brain mass, and with no histomorphologic abnormalities. We demonstrate that the binding of KIDINS220 to TrkA is diminished by the deletion mutation. This family is the second that associates a KIDINS220 genetic variant with human ventriculomegaly and limb contractures, validating causality of the gene and indicating TrkA as a likely mediator of the phenotype.
A Legal Black Hole in the Cosmos of Virtue—The Politics of Human Rights Critique Against the World Bank
Authors: Van Den Meerssche Dimitri 
Published: November 2020

ABSTRACT
The World Bank is often portrayed by human rights scholars as a ‘legal black hole’ where the workings of international law have been suspended. In a recognizable routine of human rights activism, consistent attempts are therefore made to throw out the normative net of international law over this institutional domain. A familiar response by the institution is the assertion of its autonomous international legal status and constitutional limitations. Rather than reaffirming a specific position in this deadlocked doctrinal debate, this article enquires into the performative effects of this jousting routine between human rights activists and the World Bank. The account points to the potentially problematic political effects indirectly and unwillingly engendered by repeated enactments of these deeply engrained juridical juxtapositions. This analysis provides an innovative, relational understanding of international law with analytical value beyond the scope of this particular debate.