bluuebunny/crossref_metadata_2025_split huggingface dataset:
WHO speaks for autism?: Nonprofit organizations, stakeholder activists and the ethics of representation
Authors: Stones Emily 
Published: February 2025

Research methodology
This case analyzed a mix of publicly accessible primary and secondary sources ranging from blog posts to academic articles. Taken together, the case study shows the reoccurring arguments made by self-advocates.
Most of the videos and speeches mentioned in this case study are available online, and students can read/watch them in addition to reading the details presented here.

Case overview/synopsis
Autism Speaks entered the nonprofit scene in 2005 and rapidly became a powerful organization that raised substantial funds, collaborated with influential people and shaped public discourse on autism. However, from the beginning, the organization faced considerable criticism from self-advocates within the autism community who argued that the organization’s negative, medicalized narratives of autism undermined the neurodiversity movement’s goals of acceptance and inclusion. Tensions intensified over the next decade, with grassroots activists and disability rights organizations like the Autistic Self Advocacy Network demanding the inclusion of more autistic perspectives in the organization’s leadership and decision-making processes. The Autism Speaks controversy represents a powerful case study on how nonprofits should ethically represent their beneficiaries, collaborate with the community and engage with activist stakeholders.

Complexity academic level
This case study was designed for graduate or undergraduate students studying organizational ethics, nonprofit management or nonprofit funding and development.
A crossroads between greener pastures and local loyalty: Scott Baker’s decision on the future location of 5 Generation Bakers
Authors: Allen Samuel , Murrell Audrey J. , Jones Ray , Misic Luka 
Published: February 2025

Research methodology
This case study draws on secondary sources, which are cited in the case and included in the “References and Other Supporting Materials” section of the teaching note, as well as a semi-structured interview with the case’s protagonist to accurately portray the context, considerations and competing interests necessary for students to make an evidence-based recommendation about 5 Generation Bakers’ future. The case protagonist (Scott Baker) gave the author team written permission to use identifying information from the interview. As such, the authors made no attempt to disguise any names or facts pertaining to this case. As a descriptive incident, it illustrates widely used theoretical concepts and models. The case provides students the opportunity to identify theoretical concepts and practical management strategies moving forward in academic and management settings. No AI was used in writing either the case or teaching notes.

Case overview/synopsis
Scott Baker, owner of 5 Generation Bakers in McKees Rocks, PA, found himself in a difficult position in October 2015. Needing to find a new facility to expand his bakery business and meet the needs of the modern bakery industry, Scott was on his way to a meeting with officials from Cranberry Township promising a sleek, modern facility in an area with lower taxes and promising access to transportation. This tempting offer came at a cost: uprooting his loyal employees and abandoning McKees Rocks after several decades of his family operating a bakery there. On that October day, a twist emerged – the newly vacant lot of a recently closed Bottom Dollar store offered a chance to expand locally. Now, the family business owner had to decide: pursue the new facility in Cranberry, or revitalize his business and stay local. This case is widely applicable but is most directly relevant to modules related to ethics, corporate social responsibility, family business dynamics and stakeholder management analysis in management and leadership courses.

Complexity academic level
This case is most applicable to business students at the undergraduate or graduate level in entrepreneurship, business strategy, ethics, or related fields. The case is particularly relevant for modules in decision-making, corporate social responsibility, stakeholder management and family business dynamics.
Crafting empowerment through Madhubani painting: the journey of rural women artisans
Authors: Singh Neha , Kaur Kulvinder , Moid Sana , Rehman Anis Ur , Rushdi Naela Jamal 
Published: February 2025

PurposeThis study aims to unveil the realities of Madhubani painting women artisans in the Mithila region of Bihar. It delves into the theory of capitalism concerning women artisans and their challenges and explores potential avenues for empowerment.Design/methodology/approachUtilizing an interpretative qualitative technique, the research focused on Madhubani Painting Women Artisans of Bihar. Semi-structured face-to-face interviews were conducted, and the resulting data were analysed using thematic analysis.FindingsThe findings revealed 22 sub-themes grouped into five themes. The first three themes are based on the theory of capitalism, including human, social and economic capital related to Madhubani painting women artisans. The following two themes included challenges faced by women artisans and notable opportunities within an emerging market.Research limitations/implicationsThe geographical focus, reliance on qualitative data, limited stakeholder perspectives and short timeframe may restrict the generalizability, breadth of insights and long-term impact assessment, highlighting the need for broader future research.Practical implicationsThis research implies that there is a need to enhance digital skills, boost IT infrastructure and continuous support from the government to empower rural women artisans, fostering economic growth, entrepreneurship and cultural preservation in the handicraft sector.Originality/valueThis research contributes to the limited body of knowledge regarding the experiences of women artisans, shedding light on the unique themes and subthemes. The study underscores the significance of preserving traditional art forms and cultural heritage while striving for improved economic empowerment and social inclusion.
Assessment of mechanical and microstructural properties of concrete using titanium dioxide with recycled and virgin aggregates
Authors: Khungar Hariom P. , Kondraivendhan B. , Parmar Nilesh R. 
Published: February 2025

Purpose
The construction industry’s pursuit of sustainable and high-performance materials has led to the exploration of alternative aggregates and innovative additives. This paper investigates the combined influence of recycled aggregates (RA) and nano TiO2 particles on M20 and M30 concretes, addressing ecological concerns and seeking to improve material properties. RA, sourced from construction and demolition waste, presents a sustainable solution to alleviate the environmental impact associated with traditional virgin aggregates (VA). However, challenges related to the mechanical strength and durability often hinder the widespread use of RA in concrete. This study aims to bridge this gap by exploring the reinforcing potential of nano TiO2 particles.

Design/methodology/approach
Nanomaterial such as TiO2 is known for its photocatalytic properties and reinforcement capabilities and has emerged as a promising additive in construction materials. The investigation herein involves the incorporation of nano TiO2 at percentages of 0.5% and 1% in both VA- and RA-based M20 and M30 concretes. Comprehensive series of tests on mechanical, durability and microstructural properties are conducted for each concrete mix.

Findings
Results unequivocally indicate that the addition of TiO2 significantly improves the properties of concrete, with RA-based concrete exhibiting performance comparable to that of VA-based counterparts. This breakthrough suggests a viable application of RA with TiO2 in construction projects, promoting sustainability without compromising performance. Following experimental analyses, linear regression and multiple linear regression analyses are used to establish predictive equations correlating interfacial transition zone (ITZ) thickness with TiO2 percentage, compressive strength, tensile strength, flexural strength and chloride penetration.

Originality/value
These equations serve as valuable tools for predicting ITZ thickness in future concrete formulations based on specified parameter quantities, thereby contributing to informed decision-making in sustainable construction practices. The findings of this study have the potential to contribute to the improvement of environmentally conscious construction methods while also improving the performance and durability of concrete structures.
Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases
Authors: Zhang Tianli , Toyomoto Touya , Sawa Tomohiro , Akaike Takaaki , Matsunaga Tetsuro 
Published: February 2025

ABSTRACTSupersulfides are molecular species characterized by catenated sulfur moieties, including low‐molecular‐weight and protein‐bound supersulfides. Emerging evidence suggests that these molecules, abundantly present in diverse organisms, play essential roles far beyond their chemical properties, such as functions in energy metabolism, protein stabilization, and antiviral defense. Recent studies highlight their regulatory effects on pattern‐recognition receptors (PRRs) and associated signaling pathways–such as nucleotide oligomerization domain‐like receptor signaling, toll‐like receptor signaling, and type I interferon receptor signaling–critical for innate immunity and inflammatory responses. Dysregulation of these pathways is implicated in a heterogeneous group of autoinflammatory diseases, including inflammasomopathies, relopathies, and type I interferonopathies, respectively. Notably, both endogenous and synthetic supersulfide donors have recently shown promising inhibitory effects on PRR signaling, offering their potential as targeted therapies for managing autoinflammatory conditions. This review summarizes the fundamental biology of supersulfides and typical autoinflammatory diseases, focusing on their roles in innate immune and inflammatory responses, while exploring their therapeutic potential in these diseases.
From politics to economics: The investigation of the determinants of local administrative hierarchy in the Tang–Song transition
Authors: Li Nan , Cai Heqi 
Published: February 2025

AbstractThis study collects original data to examine the determinants of classification criteria of county hierarchy and its rank variations during the Tang–Song period. The results reveal that the county hierarchy was affected by both economic and political situations, with more emphasis on politics in Tang and economics in Song. By comparing the county ranks through two dynasties, we find that political factors influenced rank elevation mainly near the capital while economic factors emerged as the primary driver of rank increases in southern regions, reflecting the economic center southward shift during the Tang–Song Transition.
A morphological identification key to the mosquito disease vectors of the Pacific
Authors: Gyawali Narayan , Russell Tanya L. , Burkot Thomas R. , Devine Gregor J. 
Published: February 2025

AbstractAn identification guide is provided for female adults of the mosquito groups, complexes or species that can be morphologically differentiated and that are likely to transmit arboviruses (e.g., dengue, Zika, chikungunya, Ross River and Japanese encephalitis) or parasites (e.g., Plasmodium spp. and Wuchereria bancrofti) in the Pacific Islands, countries and territories. This dichotomous key is adapted, with permissions, from a variety of text and image sources to facilitate the identification of disease vectors by individuals with limited taxonomic training including Pacific island country Vector Surveillance and Environmental Health officers, other public health officials and students.
Thoracic Cancer Exercise Services in Australia: A Point‐Prevalence Survey
Authors: Bowman Amy , Denehy Linda , Edbrooke Lara 
Published: February 2025

ABSTRACTBackgroundCancer guidelines recommend pre‐ and rehabilitation; however, current research shows these services are not well integrated into clinical practice. To date, there has been no prospective audit of Australian lung cancer exercise services or the people accessing these services. The aim of this study was to describe the exercise pre‐ and rehabilitation services available to people with thoracic cancer and the characteristics of people with thoracic cancer attending these services in Australia.MethodsProspective, observational, multicenter, 5‐day, point‐prevalence study. Australian healthcare services likely to provide exercise services to people with thoracic cancer were contacted to participate. Conduct and reporting followed the CROSS guidelines.ResultsA total of 397 services were contacted, and 203 responded (51%). Overall, 67% (n = 137) accepted thoracic cancer referrals, and 107 (78%) completed the survey. Most exercise services were targeted at respiratory disease (58%, n = 60) compared with 31% cancer‐specific (n = 33) and 5% lung cancer‐specific (n = 5). A total of 73 patients with thoracic cancer attended programs across 41 sites (38%). Mean (SD) age was 68.5 (9.7) years. Overall, 4% of patients (n = 3) were culturally and linguistically diverse, and none identified as Aboriginal or Torres Strait Islander. A total of 19 outcomes were used in 51 combinations to assess participants (n = 70), and 12 exercise interventions were delivered in 45 combinations (n = 67).ConclusionsOne‐third of responding exercise programs did not offer exercise services to people with thoracic cancer. Almost two‐thirds of services that accept referrals did not have a thoracic cancer patient attend their service. High heterogeneity in outcome measures and exercise interventions was observed.
Marginal Indication for Thoracoscopic Surgery for Neonatal Bochdalek Hernia: “Anchor‐Shaped Closure” Technique for the Patient's Own Residual Diaphragm Using a Loop Needle Device
Authors: Kedoin Chihiro , Sugita Koshiro , Harumatsu Toshio , Tabata Yumiko , Iwamoto Yumiko , Ogata Masato , Takada Lynne , Nagano Ayaka , Tsuruno Yudai , Murakami Masakazu , Yano Keisuke , Onishi Shun , Kawano Takafumi , Ieiri Satoshi 
Published: February 2025

ABSTRACTIntroductionSurgical procedures to avoid using artificial materials require ongoing discussion. We herein report a case of thoracoscopic repair for congenital diaphragmatic hernia (CDH) via anchor‐shaped closure with the patient's own residual diaphragm using a loop needle device.Patient and Surgical TechniqueA 2‐day‐old boy prenatally diagnosed with CDH underwent thoracoscopic repair after his respiratory and circulatory conditions had stabilized. The defect was a typical Bochdalek CDH, approximately 2.5 × 4 cm. The herniated organs of the thoracic cavity were the stomach, small intestine, colon, spleen, and left kidney. After these organs had been gently returned to the abdominal cavity under artificial pneumothorax, the medial side of the defect was closed in the anterior and posterior directions with six stitches of Loeder's knot using 3–0 non‐absorbable sutures. However, the lateral third of the defect was relatively large and difficult to close in the anterior and posterior directions. We therefore opted for closure by fixing the diaphragm to the chest wall and driving five external costal sutures using a loop needle device. The diaphragmatic defect was thus closed in an “anchor‐shaped” fashion using the patient's own residual diaphragm. This technique allows artificial membranes to be avoided in infants.DiscussionConsidering the possibility of recurrence and complications, the indications for our procedure are limited; however, we believe that there are cases in which this procedure can provide a cure. Our proposed technique may be effective in closing relatively large diaphragmatic defects.
Comparison of Post‐Radical Cystectomy Renal Function and Ileal Conduit‐Related Complications Between Extracorporeal and Robot‐Assisted Intracorporeal Urinary Diversion: A Single‐Center Experience
Authors: Miyake Makito , Nishimura Nobutaka , Oda Yuki , Miyamoto Tatsuki , Tomizawa Mitsuru , Shimizu Takuto , Owari Takuya , Iida Kota , Ohnishi Kenta , Hori Shunta , Morizawa Yosuke , Gotoh Daisuke , Nakai Yasushi , Inoue Takeshi , Anai Satoshi , Tanaka Nobumichi , Fujimoto Kiyohide 
Published: February 2025

ABSTRACTIntroductionLimited evidence exists regarding differences in post‐operative renal function and ileal conduit‐related complications, including ureteroenteric anastomotic stricture (UAS) and parastomal hernia (PH), between radical cystectomy (RC) with extracorporeal urinary diversion (ECUD) and robot‐assisted RC with intracorporeal UD (ICUD).MethodsWe retrospectively collected the baseline and post‐RC follow‐up data from 179 patients receiving RC with ileal conduit UD (152 ECUD and 27 ICUD). The estimated glomerular filtration rate (eGFR, mL/min/1.73 m2) and occurrence of UAS and PH were post‐operatively monitored. Chronic kidney disease (CKD) stages were determined based on eGFR level. UD‐related complications were evaluated using the Clavien‐Dindo system. Time‐course changes in eGFR level and CKD‐related survival rates were compared in both the original and propensity score‐matched cohorts.ResultsAlthough the original ECUD group had higher eGFR levels (median, 60.9 vs. 52.1), comparison of the adjusted cohorts revealed no significant difference at any time points, CKD upstaging‐free survival, and CKD stage 3b‐free survival. Out of 179 patients, three (1.7%), eight (4.5%), and 14 (7.8%) experienced grade I, II, and IIIa UAS, respectively. Thirteen (7.3%) developed PH during follow‐up. No significant differences were observed in UAS rates (p = 0.38), PH rates (p = 0.69), CKD upstaging‐free survival, and CKD stage 3b‐free survival between two groups.ConclusionNo significant difference was observed in post‐operative renal function and UD‐related complication rates among the different types of surgery in patients undergoing RC in our institute. Further research is needed to determine the optimal surgical approach for each patient to minimize risks of CKD upstaging, UAS, and PH.
Exploring the Out‐Group Homogeneity Effect Among Arab Children in Israel: The Roles of Religion, Contact, and Group Identification
Authors: Essa Francine , Rakoczy Hannes , Diesendruck Gil 
Published: February 2025

ABSTRACTThe out‐group homogeneity effect has been found to contribute to adults' inter‐group biases. Three studies examined whether 5‐ and 8‐year‐old Arab (i.e., minority) children in Israel also manifest this effect (March 2017–January 2020). Arab children from different religious affiliations and social environments (N = 272, 54% females) were asked to choose either a homogeneous or a heterogeneous sample of group members to infer if a given property (biological or psychological) was true of a whole group: either the participant's in‐group (Arabs) or out‐group (Jews). Overall, differently from Jewish (i.e., majority) Israeli children, Arab children did not exhibit the out‐group homogeneity effect. Nevertheless, there were indications that religious affiliation, social environment, and group identification affected children's responses.
Intrahepatic Cholestasis of Pregnancy: A Single‐Centre Whole‐Exome Sequencing Study in a Maltese Cohort
Authors: Spiteri Dorianne , Grech Laura , Savona‐Ventura Charles , Pace Nikolai Paul 
Published: February 2025

ABSTRACTIntrahepatic cholestasis of pregnancy (ICP) has a multifactorial pathophysiology involving genetic, endocrine, and environmental factors. It is associated with maternal distress and adverse foetal outcomes. The monogenic aetiology of ICP remains unexplored in the Maltese population. We apply whole exome sequencing in 20 unrelated index cases to assess the molecular spectrum of variants in genes linked to bile acid transport. We shortlisted five unique heterozygous variants. Three ABCB4 variants, including a novel likely pathogenic stop‐gain variant were detected. Three genealogically unrelated cases carried an ABCB4 p.Asn510Ser variant, suggestive of a founder through shared haplotype analysis. This study provides preliminary insight into the monogenic aetiology of ICP from an unstudied population. It expands the spectrum of genetic variants associated with ICP and provides evidence for a founder effect in the Maltese population.
Astaxanthin Inhibits Ferroptosis of Hippocampal Neurons in Kainic Acid‐Induced Epileptic Mice by Activating the Nrf2/GPX4 Signaling Pathway
Authors: Chen Shihao , Zhao Linqian , Jin Xing , Liu Qichang , Xiao Yuqing , Xu Huiqin 
Published: February 2025

ABSTRACTBackgroundEpilepsy, a prevalent neurological disorder, is distinguished by episodic abnormal discharges of neurons within the brain, resulting in transient brain dysfunction. Prior research has identified a novel form of cell death termed ferroptosis, which is intricately linked to the initiation and progression of epilepsy. It has been demonstrated that astaxanthin (AST) can inhibit ferroptosis by enhancing the activity of nuclear factor erythroid 2‐related factor 2 (Nrf2), thereby providing cytoprotection. Therefore, this study aims to investigate whether AST can alleviate neuronal ferroptosis in epilepsy by activating the Nrf2/GPX4 pathway, thereby exerting a neuroprotective effect.MethodsBy constructing a kainic acid (KA)‐induced epilepsy mouse model and a KA‐induced HT22 cell model, we employed behavioral testing, Western blot analysis, quantitative real‐time reverse transcription qRT‐PCR, ferroptosis‐related assay kits, immunofluorescence staining, and other methods. These methodologies were utilized to investigate the protective effects and underlying mechanisms of AST on ferroptosis in KA‐induced epileptic mice and HT22 neurons.ResultsOur results demonstrate that AST pretreatment alleviates KA‐induced epileptic behaviors and cognitive impairments in mice and mitigates ferroptosis indicators such as lipid peroxidation and mitochondrial morphological alterations. This neuroprotective effect appears to be mediated by the activation of the Nrf2/GPX4 signaling axis. In vitro studies further revealed that AST confers neuroprotection against KA‐induced HT22 neuronal cell death, an effect that is abrogated by an Nrf2 inhibitor. Hence, the neuroprotective properties of AST are significantly associated with the modulation of the Nrf2‐mediated ferroptosis pathway, as corroborated by bioinformatics analyses.ConclusionThe AST effectively inhibits neuronal ferroptosis in both in vivo and in vitro epilepsy models via the Nrf2/GPX4 pathway. This finding suggests that AST holds promise as a potential therapeutic agent for the treatment of epilepsy.