bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN PREMI, PENDAPATAN INVESTASI DAN SURPLUS UNDERWRITTING PADA KEUNTUNGAN PT. ASURANSI JASINDO TAKAFUL
Authors: Satata Elsha Dwi Angganis , Septiarini Dina Fitrisia 
Published: November 2020

ABSTRAKAsuransi syariah merupakan salah satu upaya untuk saling melindungi dan saling membantu antar beberapa pihak melalui investasi pada aset dan atau tabarru yang memberikan pola pengembalian untuk menghadapi risiko tertentu melalui suatu kontrak yang sesuai dengan prinsip syariah. Salah satu kegiatan utama perusahaan baik asuransi konvensional maupun syariah adalah penjaminan emisi. Penelitian ini bertujuan untuk mengetahui pengaruh variabel premi, pengembalian investasi dan dana penjaminan surplus tabarru terhadap laba PT Asuransi Takaful Jasindo baik secara parsial maupun simultan. Penelitian ini menggunakan pendekatan kuantitatif dengan menggunakan data sekunder berupa laporan keuangan PT Asuransi Takaful Jasindo periode 2011-2014. Penelitian ini menggunakan taraf signifikansi 5%. Hasil regresi dalam penelitian ini menunjukkan bahwa variabel premi berpengaruh signifikan terhadap laba asuransi, sedangkan variabel hasil investasi dan surplus dana penjaminan tabarru tidak berpengaruh signifikan terhadap laba asuransi syariah.Kata Kunci: Jasindo Takaful, Premi, Pendaptan Investasi, Surplus Underwriting Tabarru', Laba Asuransi ABSTRACTIslamic insurance is one of the efforts to protect each other and mutual help among several parties through investment in assets and or tabarru which provide pattern returns to face certain risks through a contract in accordance with Islamic principles. One of the main activities of the company both conventional and Islamic insurance is underwriting. This study aims to determine the effect of variable premium, return on investment and underwriting surplus funds tabarru to profits Jasindo PT Asuransi Takaful insurance either partially or simultaneously. This study uses a quantitative approach using secondary data such as financial statements of PT Asuransi Takaful Jasindo period 2011-2014. This study used a significance level of 5%. The regression results in this study indicate that the variable premium significantly affects insurance profit, while the variable investment returns and underwriting surplus funds tabarru not significantly affect on earnings Islamic insurance.Keyword: Jasindo Takaful, Premiums, Return on Investment, Underwriting Surplus Tabarru', Profit Insurance
Interferon Inducible Porcine 2′, 5′-oligoadenylate Synthetase-Like Protein Limits Porcine Reproductive and Respiratory Syndrome Virus Infection via the MDA5-Mediated Interferon-Signaling Pathway
Authors: Zhao Mengmeng , Kong Weili , Kang Yinfeng , Li Huawei 
Published: November 2020

Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) is a constant threat to the swine industry worldwide. Currently approved vaccines against PRRSV are losing effectiveness, as new viral strains are often refractory to conventional treatments. Thus, there is an urgent need to find new therapeutic targets to develop novel antiviral drugs. 2′, 5′-oligoadenylate synthetase-like (OASL) protein has antiviral activity, but this has not been demonstrated for PRRSV and the mechanism is not well elucidated. In this study expression of porcine OASL (pOASL) in porcine alveolar macrophages (PAMs) induced by interferon (IFN) -β stimulation and PRRSV infection was examined by real-time polymerase chain reaction (RT-PCR). Exogenous expression and knockdown of pOASL were used to indicate the role of pOASL in the PRRSV replication cycle. The type I IFN signaling pathway was evaluated after pOASL overexpression. Results showed the expression of pOASL in PAMs was significantly increased by IFN-β stimulation or PRRSV infection. pOASL specific small interfering RNA (siRNA) promoted PRRSV replication, whereas exogenous expression of pOASL inhibited infection of PRRSV. The anti-PRRSV activity was lost after knockdown of the Melanoma differentiation-associated protein 5 (MDA5) RNA sensor. Taken together, pOASL inhibits PRRSV infection via the activation of MDA5.
High Prevalence Of Alphaherpes Virus 2 (HSV-2) Positivity In Prisons From Midwest Brazil: A Cross-Sectional Study
Authors: Almeida Nathália Alves Araujo de , Lima Lyana Rodrigues Pinto , Puga Marco Antonio Moreira , Croda Julio , Horta Marco Aurelio , Motta-Castro Ana Rita Coimbra , Paula Vanessa Salete de 
Published: November 2020

Abstract
Background: The Herpes simplex virus type 2, currently classified as Human alphaherpesvirus 2 (HSV-2) is the main cause of genital herpes, one of the most prevalent sexually transmitted infections (STIs) in the world. STIs are one of the major public health problems in prisons due to the behaviors of prisoners and the factors that increase the risk of transmission. The present study aimed to estimate the prevalence and risk factors associated with HSV-2 infection at 12 prisons in Mato Grosso of Sul, Brazil. Results: We tested 872 serum samples (732 males and 140 females) for anti-HSV-2 IgG and anti-HSV-2 IgM. The overall HSV-2 IgG prevalence was 43.1%, and the prevalence was greater in males than females (32.1% vs. 11%). The prevalence of HSV-2 in females were 3.4 times more than in males in adjusted model. Among the 184 samples HSV-2 IgG tested for IgM anti HSV-2, 46% were positive. The prevalence of HSV-2 positivity was much greater than reported in the general population of Brazil and in other prison populations worldwide. The multivariable model adjusted, indicated significant and independent associations of HSV-2 IgG positivity with female sex, age older than 29 to 39 years, unmarried status, history of STI, no previous incarceration, being incarcerated with more than 26 others, presence of genital discharge, previous homosexual intercourse, HIV-positivity, and no use/occasional use of condoms during sexual intercourse. Conclusions: This is the first study that evaluated HSV-2 in a prison population in Brazil. These data provide important information needed to implement procedures that better prevent and control of STIs in prison populations.
Psychometric Properties of an English Short Version of the Trier Inventory for Chronic Stress
Authors: Petrowski Katja , Braehler Elmaer , Schmalbach Bjarne , Hinz Andreas , Bastianon Christina , Ritz Thomas 
Published: November 2020

Abstract
Background: Although a variety of instruments are available that capture stress experience, the assessment of chronic stress has been hindered by the lack of economical screening instruments. Recently, an English-language version of the Trier Inventory for Chronic Stress (TICS-EN) consisting of 57 items according to a systemic-requirement-resource model of health in nine subdomains of the chronic stress experience has been introduced.Methods: We constructed a new 9-item short version of the TICS covering all nine subdomains and evaluated it in two samples (total N=685). We then used confirmatory factor analysis to check factorial validity.Results: This version showed a highly satisfactory model fit, was invariant across participant gender, demonstrated a very high correlation with the original TICS (r=.94), and showed a moderate correlation (r=.58) with a measure of perceived stress in the past month.Conclusions: Therefore, this theoretically driven instrument can be recommended as a short version of the TICS in English language.
Association between response to triptans and response to erenumab: real-life data
Authors: Frattale Ilaria , Caponnetto Valeria , Casalena Alfonsina , Assetta Maurizio , Maddestra Maurizio , Marzoli Fabio , Affaitati Giannapia , Giamberardino Maria Adele , Viola Stefano , Gabriele Amleto , Pistoia Francesca , Cerone Davide , Marini Carmine , Sacco Simona , Ornello Raffaele 
Published: November 2020

Abstract
Background. Triptans and erenumab are both migraine-specific agents acting on the calcitonin gene-related peptide pathway. Therefore, response to triptans might be associated with response to erenumab. Main body. In our study, consecutive patients referring to the Headache Centers of the Abruzzo region from January 2019 to March 2020 and treated with erenumab were interviewed about past use and efficacy of triptans. Triptan users were classified as ‘triptan responders’ if they were headache-free 2 hours after treating ≥3 migraine attacks with ≥1 triptan. We considered patients as ‘erenumab responders’, if they had a ≥50% mean reduction in monthly migraine days between the 4th and the 6th month from treatment start compared with baseline. Of 91 triptan users, 73 (80.2%) were triptan responders and 58 (63.7%) were erenumab responders. The odds ratio of being erenumab responder was 3.64 (95% CI, 1.25-10.64) for triptan users as compared to non-users. (P=0.014). Besides, starting erenumab improved triptan response in both erenumab responders and non-responders. Conclusions. Our data of an association between response to triptans and response to erenumab can be useful for patient advice and to improve the understanding of migraine pathophysiology and treatment.
Magnetism-induced topological transition in EuAs3
Authors: Cheng Erjian , Xia Wei , Xu Jie , Wang Chengwei , Xi Chuanying , Xu Shaowen , Peets Darren , Wang Linshu , Su Hao , Pi Li , Ren Wei , Wang Xia , Yu Na , Chen Yulin , Zhao Weiwei , Liu Zhongkai , Guo Yanfeng , Li Shiyan 
Published: November 2020

Abstract
The nature of the interaction between magnetism and topology in magnetic topological semimetals remains mysterious, but may be expected to lead to a variety of novel physics. We present ab initio band calculations, electrical transport and angle-resolved photoemission spectroscopy (ARPES) measurements on the magnetic semimetal EuAs3, demonstrating a magnetism-induced topological transition from a topological nodal-line semimetal in the paramagnetic or the spin-polarized state to a topological massive Dirac metal in the antiferromagnetic (AFM) ground state at low temperature, featuring a pair of massive Dirac points, inverted bands and topological surface states on the (010) surface. Shubnikov-de Haas (SdH) oscillations in the AFM state identify nonzero Berry phase and a negative longitudinal magnetoresistance (n-LMR) induced by the chiral anomaly, confirming the topological nature predicted by band calculations. When magnetic moments are fully polarized by an external magnetic field, an unsaturated and extremely large magnetoresistance (XMR) of ∼ 2×105 % at 1.8 K and 28.3 T is observed, likely arising from topological protection. Consistent with band calculations for the spin-polarized state, four new bands in quantum oscillations different from those in the AFM state are discerned, of which two are topologically protected. Nodal-line structures at the Y point in the Brillouin zone (BZ) are proposed in both the spin-polarized and paramagnetic states, and the latter is proven by ARPES. Moreover, a temperature-induced Lifshitz transition accompanied by the emergence of a new band below 3 K is revealed. These results indicate that magnetic EuAs3 provides a rich platform to explore exotic physics arising from the interaction of magnetism with topology.
Factors Influencing Post-ICU Psychological Distress in Family Members of Critically Ill Patients: A Linear Mixed-Effects Model
Authors: Naef Rahel , Felten Stefanie van , Ernst Jutta 
Published: November 2020

Abstract
Background: Adverse responses to critical illness, such as symptoms of depression, anxiety or posttraumatic stress, are relatively common among family members. The role of risk factors, however, remains insufficiently understood, but may be important to target those family members most in need for support. We therefore examined the association of patient-, family member- and care-related factors with post-ICU psychological distress in family members in a general population of critical ill patients.Methods: We conducted a prospective, single-centre observational study in a twelve-bed surgical ICU in a 900-bed University Hospital in Switzerland. Participants were family members of patients treated in ICU who completed the Family Satisfaction in ICU-24 Survey, the Hospital Anxiety Depression Scale, Impact of Event Scale-Revised-6, and a demographic form within the first three months of their close other’s ICU stay. Data were analysed using linear mixed-effects models, with depression, anxiety, and posttraumatic stress as outcome measures. Results: A total of 214 family members (53% return rate) returned a completed questionnaire. We found that higher levels of satisfaction were significantly associated with lower levels of depression, anxiety and posttraumatic stress. There was no statistically significant association between family member characteristics and any measure of psychological distress. Among the included patient characteristics, younger patient age was associated with higher levels of depression and anxiety, and patient death was associated with higher levels of depression and posttraumatic stress.Conclusions: Our results suggest that satisfaction with ICU care is strongly associated with family well-being post-ICU. Family members of younger patients and of those who die seem to be most at risk for psychological distress, requiring specific support, whereas family member characteristics may have less relevance.
Pilot study protocol for determining differences in quantitative and functional aspects of dendritic cell subsets in early onset pre-eclampsia patients- a feasibility study for identification of biomarker(s) and immunotherapeutic target(s)
Authors: Sundararajan Aarthi , Vora Kranti , Natesan Senthilkumar 
Published: November 2020

Abstract
Background: Pre-eclampsia (PE) is a pregnancy associated pro-inflammatory disorder. The only known treatment is to deliver the placenta and fetus. PE is clinically identified by hypertension and proteinuria post-20th week of gestation. Early onset pre-eclampsia (EOPE), a severe form of PE is defined as when the clinical symptoms are observed before 34 weeks of gestation. There are no definite biomarkers available for early diagnosis of EOPE. Human dendritic cell (DC) subsets (CD1c+, CD141+ myeloid DCs and plasmacytoid DCs) are intricately involved with the process of inflammation and are significantly altered (quantitatively and functionally) in several proinflammatory disorders. These changes offer value for monitoring DC subsets as potential biomarker(s) and as targets for immunotherapeutic treatment. DC subsets play a critical role in normal pregnancy by mediating efficient migration and invasion of trophoblasts and maintaining anti-inflammatory environment of immunotolerance. In contrast, the status of DC subsets in the proinflammatory microenvironment of EOPE pregnancy requires thorough evaluation. In this direction, the designed study protocol aims to understand how DC subsets are altered (quantitatively and functionally) in EOPE patients, compared to normal pregnant women. Methods: Study protocol is designed to determine changes in the profile of DC subsets in the blood and decidua of EOPE patients by multiparametric flow cytometry approach. Normal pregnant women are included as controls.Discussion: Human DC subsets are altered both quantitatively and functionally in the pro-inflammatory microenvironment. EOPE is a pro-inflammatory disorder and changes in the composition and function of DC subsets in these patients, compared to normal pregnant women is unclear. In this study, the blood sample-based analysis will determine the feasibility for identification of DC subsets associated novel immune biomarkers for early diagnosis of EOPE. In addition, changes in the profile of DC subsets in the decidua of EOPE patients will determine the feasibility for developing novel immunotherapeutic strategies targeting distinct DC subsets or their products for the treatment of EOPE. Overall, the current study protocol and findings will help develop future large scale, prospective design clinical trials focussing on formulating strategies for early diagnosis and treatment of EOPE among pregnant women.
Machine Learning Models for Breast Lesions Based on Ultrasound Imaging Features: A Observational Study
Authors: Tan Yao , Huo Ling , Wang Shu , Geng Cuizhi , Li Yi , Ma XiangJun , Wang Bin , He YingJian , Yao Chen , Ouyang Tao 
Published: November 2020

Abstract
Background: The accuracy of breast cancer (BC) screening based on conventional ultrasound imaging examination largely depends on the experience of clinicians. Further, the effectiveness of BC screening and diagnosis in primary hospitals need to be improved. This study aimed to establish and evaluate the usefulness of a simple, practical, and easy-to-promote machine learning model based on ultrasound imaging features for diagnosing BC.Methods: Logistic regression, random forest, extra trees, support vector, multilayer perceptron, and XG boost models were developed. The modeling data set was divided into a training set and test set in a 75%:25% ratio, and these were used to establish the models and test their performance, respectively. The validation data set of primary hospitals was used for external validation of the model. The area under the receiver operating characteristic curve (AUC) was used as the main evaluation index, and pathological biopsy was used as the gold standard for evaluating each model. Diagnostic capability was also compared with those of clinicians. Results: Among the six models, the logistic model showed superior capability, with an AUC of 0.771 and 0.906 in the test and validation sets, respectively, and Brier scores of 0.18 and 0.165. The AUC of the logistic model in tertiary class A hospitals and primary hospitals was 0.875 and 0.921, respectively. The AUCs of the clinician diagnosis and the logistic model were 0.913 and 0.906. Their AUCs in the tertiary class A hospitals were 0.890 and 0.875, respectively, and were 0.924 and 0.921 in primary hospitals, respectively. Conclusions: The logistic regression model has better overall performance in primary hospitals, and the logistic regression model can be further extended to the basic level. A more balanced clinical prediction model can be further established on the premise of improving accuracy to assist clinicians in decision making and improve diagnosis.Trial Registration: http://www.clinicaltrials.gov. ClinicalTrials.gov ID: NCT03080623.
Food Poisoning and Care-Seeking Behavior - Cases of Students from the City of Mohammedia in Morocco - Prospective Study
Authors: Lamine Hasna , ouanouche Elhassan , Soulaymani Abdelmajid , Khadmaoui Abderrazzak: 
Published: November 2020

Abstract
Background: Food poisoning is a problem that affects public health. It is unveiling opens an opportunity for action to identify and avoid the problem. The main objective of this study is to analyze the environmental factors that influence the obligation to consult a doctor or not following food poisoning.Methods: The study was conducted, following a prospective survey, on a sample of 408 students chosen at random from six schools of urban origin in the city of Mohammedia in Morocco.Results: 33.6% of the students confirmed having consulted the doctor against 66.4% after food poisoning. In the same way, we found that 16.2% (n = 66) of the students who declared poisoning following the consumption of an offending food were hospitalized. In addition, only 13.6% of intoxicated carried out analyzes were requested by the consultant doctor. 59.3% of the drugs prescribed by doctors are anti-infectious followed by gastro-entero-hepatology 15.4% and 12.3% are analgesics.Conclusions: Overall, this study confirms that food poisoning is very frequent among students in Morocco, so parents should be educated about the danger of food poisoning in their children, by presenting them to a doctor immediately after contamination to avoid complications.
Ethyl Acetate Extracts of Bushen-Yizhi Formula Attenuates Aging-Induced Dementia through Suppressing NLRP3 Inflammasome Activation in SAMP8 Mice
Authors: Su Shi-Jie , Cai Wei-Wu , Liu Hao-Fei , Zhang Shi-Jie , Wang Qi , Liu Si-Jun 
Published: November 2020

Abstract
Background: Similar features indicated common regulators between aging and aging-induced dementia, which demonstrated profound correlations with each other. However, the mechanism remains unclear. Bushen-Yizhi Formula(BSYZ-F) has been used for managing dementia in the clinic for hundreds of years. In this study, we aimed to further explore the mechanism of athyl acetate extracts of BSYZ-F(BSYZ-E) attenuates aging-induced dementia in Senescence-Accelerated Mouse Prone 8 (SAMP8) mice.Methods: As an age-related model, SAMP8 mice have been assigned to receive the corresponding interventions in this study. The Morris water maze was used to evaluate the learning and memory ability in SAMP8 mice. The marker level of oxidative stress(ROS and SOD) and nitrosative stress(NO and iNOS) were measured using commercial kits. The quantification of inflammation-related proteins (NLRP3, ASC, Caspase-1, IL-1β, and IL-18) and related apoptotic proteins (Bax, Bcl-2, Caspase-3, and Cleaved-Caspase-3) in hippocampal tissue were measured using Western blot.Results: In behavioral, the Morris Water Maze test demonstrated BSYZ-E alleviated the cognitive impairments in SAMP8 mice. Mechanism studies indicated that BSYZ-E increased the vitality of SOD, declined the validity of NO, iNOS, and MDA in SAMP8 mice. Besides, BSYZ-E relieved neuronal apoptosis by regulating the expression of related apoptotic proteins (Bax, Bcl-2, Caspase-3, and Cleaved-Caspase-3) and inhibited NLRP3 inflammasome activation by inflammation-related proteins (NLRP3, ASC, Caspase-1, IL-1β, and IL-18) in SAMP8 mice. Conclusions: These results suggested that BSYZ-E attenuates aging-induced dementia by suppressing the activation of NLRP3 inflammasome in SAMP8 mice.
Allogeneic Red Blood Cell Transfusion Rate and Risk Factors in Elderly Patients with Femoral Neck Fracture after Hemiarthroplasty
Authors: Yue Rui , Yang Minghui , Deng Xiaohui , Zhang Ping 
Published: November 2020

Abstract
Objective: To determine the rate and risk factors of allogeneic red blood cell transfusions (ABT) in elderly patients with femoral neck fracture (FNF) after hemiarthroplasty (HA). Methods: We conducted a study on elderly patients (≥65 years old) who were admitted to the geriatric trauma orthopedics ward of Beijing Jishuitan Hospital for HA treatment from March 2018 to February 2019 due to FNF. The perioperative data were collected retrospectively, and univariate and multivariate stepwise logistic regression analysis were performed to determine the postoperative ABT rate and its risk factors. Results: 445 patients were included in the study, of which 177 (39.8%) received ABT after surgery. Multivariate stepwise logistic regression analysis showed that preoperative low hemoglobin (Hb), high intraoperative blood loss (IBL), advanced age, and low body mass index (BMI) are independent risk factors of ABT after HA in elderly FNF patients. Conclusion: ABT after HA is a common phenomenon in elderly patients with FNF. Their postoperative ABT needs are related to preoperative low Hb, high IBL, advanced age, and low BMI. Therefore, ABT can be reduced from the above aspects.