bluuebunny/crossref_metadata_2025_split huggingface dataset:
EL DESARROLLO DE LA CONCIENCIA PRÁGMÁTICA EN NIÑOS CON SÍNDROME DE ASPERGER
Authors: Muñoz-Burillo Lorena , Cascales-Martínez Antonia 
Published: August 2020

La conciencia pragmática es la conciencia sobre qué formas del lenguaje son apropiadas al contexto de comunicación, siendo una habilidad para darse cuenta de que uno como hablante u otras personas hacen un uso apropiado o no del lenguaje. En este caso, se analizan las perspectivas del propio niño con asperger, la familia y el terapeuta del propio niño en cuestión sobre la conciencia pragmática que tienen los niños Asperger. Para ello, elaboramos un Cuestionario de Conciencia Pragmática (CCP), compuesto por 30 ítems, el cual contestaron: 8 niños diagnosticados con SA, 7 madres y 1 padre de dichos niños y las 2 terapeutas que trabajan con ellos. El objetivo propuesto de este trabajo ha sido comparar las perspectivas de la conciencia pragmática de los alumnos con Asperger, según ellos mismos, sus familias y los terapeutas a partir del CCP. Por un lado, comparando la media de las respuestas en cada uno de los ítems pragmáticos en función de cada bloque y por otro lado, aplicando un análisis comparativo de las 3 perspectivas del CCP. Los resultados revelaron una estructura tridimensional para el CCP y las categorías se agruparon en torno a tres dimensiones pragmáticas: enunciativa, textual e interactiva.El presente trabajo constituye una pequeña aproximación al análisis del comportamiento comunicativo (verbal y no verbal) de niños con SA.
INVESTIGACIÓN EN UNIVERSIDADES DE BOGOTÁ SOBRE EL CONOCIMIENTO Y DESTREZA DE LOS FUTUROS CREADORES DE CONTENIDO DIGITAL PARA LA CONSTRUCCIÓN DE FORMATOS DE ANUNCIO EN FACEBOOK
Authors: Parra-Mayorga Ricardo Andrés 
Published: August 2020

Esta investigación tiene como propósito en primera instancia, identificar cuáles son los formatos de anuncio permitidos por la plataforma social Facebook para generar interacción con las audiencias, posteriormente, evaluar el conocimiento y la destreza que tienen los estudiantes de últimos semestres en las carreras de Publicidad, Comunicación Social y Diseño Gráfico en Bogotá, para desarrollar dichos formatos de anuncio de mensajes en Facebook. Finalmente, gracias a los resultados obtenidos, evidenciar oportunidades que permita a los creadores de contenidos, adquirir habilidades de comunicación para plataformas sociales.Para el cumplimiento de este objetivo, se desarrolló un ejercicio de investigación a modo de diagnóstico exploratorio, bajo una metodología de recolección de datos cualitativa y cuantitativa, donde los participantes debían proponer una serie de contenidos en Facebook para una marca real. Dentro de los resultados se evidenció la necesidad de profundizar en temáticas como el conocimiento de los formatos e identificación de herramientas para la construcción de mensajes multimedia en Facebook que le permita a los creadores de contenidos, mejorar sus capacidades de transmisión de mensajes en la plataforma social de estudio. Esta investigación busca aportar al campo de la innovación tecnológica desde la perspectiva académica, donde se hace necesario dotar a los futuros creadores de contenidos, de herramientas que les permita ser profesionales competitivos en el área publicitaria-digital.
Differentiation of a Contractile, Ureter-Like Tissue, from Embryonic Stem Cell–Derived Ureteric Bud and Ex Fetu Mesenchyme
Authors: Sallam May , Palakkan Anwar A. , Mills Christopher G. , Tarnick Julia , Elhendawi Mona , Marson Lorna , Davies Jamie A. 
Published: August 2020

Significance Statement
There is intense interest in engineering new kidneys from embryonic stem cells and induced pluripotent stem cells as research models, and perhaps eventually for clinical transplant. Although protocols exist for producing renal organoids from stem cells, these organoids lack an essential component, the ureter. The authors describe the production of ureter-like tissue consisting of embryonic stem cell–derived ureteric buds that organize ex fetu mesenchyme around it to form smooth muscle layers. These muscles spontaneously contract with a periodicity that is a little slower than that of peristalsis in natural ureters. This work represents a step toward developing organoids with a ureter, although inducing the tissue to elongate into a tube and connect it to the kidney is a remaining challenge.

Background
There is intense interest in replacing kidneys from stem cells. It is now possible to produce, from embryonic or induced pluripotent stem cells, kidney organoids that represent immature kidneys and display some physiologic functions. However, current techniques have not yet resulted in renal tissue with a ureter, which would be needed for engineered kidneys to be clinically useful.

Methods
We used a published sequence of growth factors and drugs to induce mouse embryonic stem cells to differentiate into ureteric bud tissue. We characterized isolated engineered ureteric buds differentiated from embryonic stem cells in three-dimensional culture and grafted them into ex fetu mouse kidney rudiments.

Results
Engineered ureteric buds branched in three-dimensional culture and expressed Hoxb7, a transcription factor that is part of a developmental regulatory system and a ureteric bud marker. When grafted into the cortex of ex fetu kidney rudiments, engineered ureteric buds branched and induced nephron formation; when grafted into peri-Wolffian mesenchyme, still attached to a kidney rudiment or in isolation, they did not branch but instead differentiated into multilayer ureter-like epithelia displaying robust expression of the urothelial marker uroplakin. This engineered ureteric bud tissue also organized the mesenchyme into smooth muscle that spontaneously contracted, with a period a little slower than that of natural ureteric peristalsis.

Conclusions
Mouse embryonic stem cells can be differentiated into ureteric bud cells. Grafting those UB-like structures into peri-Wolffian mesenchyme of cultured kidney rudiments can induce production of urothelium and organize the mesenchyme to produce rhythmically contracting smooth muscle layers. This development may represent a significant step toward the goal of renal regeneration.
Efficacy of Rituximab and Plasma Exchange in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis with Severe Kidney Disease
Authors: Casal Moura Marta , Irazabal Maria V. , Eirin Alfonso , Zand Ladan , Sethi Sanjeev , Borah Bijan J. , Winters Jeffrey L. , Moriarty James P. , Cartin-Ceba Rodrigo , Berti Alvise , Baqir Misbah , Thompson Gwen E. , Makol Ashima , Warrington Kenneth J. , Thao Viengneesee , Specks Ulrich , Fervenza Fernando C. 
Published: August 2020

Significance Statement
Efficacy of rituximab (RTX) in ANCA-associated vasculitis (AAV) in patients with severe renal involvement (eGFR<30 ml/min per 1.73 m2) has not been addressed in clinical trials. This observational study did not find statistically significant differences between RTX and cyclophosphamide (CYC) for remission-induction therapy or any apparent benefit from the addition of plasma exchange (PLEX) to standard remission-induction therapy for patients with AAV and severe renal involvement. Although our analyses suggest that the benefits and risks of these therapeutic choices (RTX versus CYC with and without PLEX) are balanced, a randomized, controlled trial is needed to confirm these findings.

Background
Treatment of patients with ANCA-associated vasculitis (AAV) and severe renal involvement is not established. We describe outcomes in response to rituximab (RTX) versus cyclophosphamide (CYC) and plasma exchange (PLEX).

Methods
A retrospective cohort study of MPO- or PR3-ANCA–positive patients with AAV (MPA and GPA) and severe kidney disease (eGFR <30 ml/min per 1.73 m2). Remission, relapse, ESKD and death after remission-induction with CYC or RTX, with or without the use of PLEX, were compared.

Results
Of 467 patients with active renal involvement, 251 had severe kidney disease. Patients received CYC (n=161) or RTX (n=64) for remission-induction, and 51 were also treated with PLEX. Predictors for ESKD and/or death at 18 months were eGFR <15 ml/min per 1.73 m2 at diagnosis (IRR 3.09 [95% CI 1.49 to 6.40], P=0.002), renal recovery (IRR 0.27 [95% CI 0.12 to 0.64], P=0.003) and renal remission at 6 months (IRR 0.40 [95% CI 0.18 to 0.90], P=0.027). RTX was comparable to CYC in remission-induction (BVAS/WG=0) at 6 months (IRR 1.37 [95% CI 0.91 to 2.08], P=0.132). Addition of PLEX showed no benefit on remission-induction at 6 months (IRR 0.73 [95% CI 0.44 to 1.22], P=0.230), the rate of ESKD and/or death at 18 months (IRR 1.05 [95% CI 0.51 to 2.18], P=0.891), progression to ESKD (IRR 1.06 [95% CI 0.50 to 2.25], P=0.887), and survival at 24 months (IRR 0.54 [95% CI 0.16 to 1.85], P=0.330).

Conclusions
The apparent benefits and risks of using CYC or RTX for the treatment of patients with AAV and severe kidney disease are balanced. The addition of PLEX to standard remission-induction therapy showed no benefit in our cohort. A randomized controlled trial is the only satisfactory means to evaluate efficacy of remission-induction treatments in AAV with severe renal involvement.
El uso del Antiguo Testamento en el nuevo: Diagnóstico y prescripción sobre el debate actual
Authors: Graf Maiorov Roy 
Published: August 2020

El uso del Antiguo Testamento en el Nuevo ha sido objeto de estudio y debate debido a las implicancias hermenéuticas quedicho uso reviste para el intérprete contemporáneo. Un grupo de eruditos bíblicos sostiene que el Nuevo Testamento hace referencia al antiguo siempre en un sentido literal, llano o atenido al contexto original. Otros en cambio, sostienen que el Nuevo Testamento hace uso de textos del Antiguo reinterpretándolos en un sentido diferente a su intención original; se asume que éstos son sacados fuera de su contexto o se les atribuye un significado adicional que no es evidente en los textos mismos. En este debate juega un papel importante el concepto de sensus plenior, que ha sido interpretado de diversas formas. el presente artículo hace un “diagnóstico” del estado actual del debate en sus diversos matices a través de una revisión de la literatura en relación al mismo, a la vez que propone algunas “prescripciones” que puedan conducir la discusión por una senda más productiva.
Effect of the consumption of a food based on fruits and natural additives in patients with cardiovascular risk
Authors: FRANCO LONDOÑO Maria Camila , ISAZA Adrián , POSADA Gladys , MALDONADO CELIS Maria Elena 
Published: August 2020

Background: cardiovascular diseases (CVD), a group of disorders of the heart and blood vessels are the main cause of morbidity and mortality worldwide. Strategies for its prevention have been proposed,
such as modifying life habits, including increasing the consumption of fruits and vegetables associated with the decrease in the probability of suffering CVD. Objective: to evaluate the effects of a base compote of guava (Psidium guajava) and passion fruit (Passiflora ligularis) on blood pressure and metabolic and inflammatory biomarkers in hypertensive type two diabetic patients. Methods: food characterization test (microbiological, proximal, sensorial, antioxidant activity and total phenols). The compote was administered for 21 days to 8 adults (30 to 65 years old); glycaemia, blood pressure, inflammatory markers, and BMI and waist circumference before and after the intervention were measured. Results: the sensory test showed: 66% acceptance and all attributes a value >3, indicating that it was well evaluated. The microbiological aspects comply with the safety for human consumption and nutritionally it stands out that the contribution of carbohydrates (12.3%) is adequate for these patients. The hydrophilic ORAC value was 98.570 μmol ET/g sample. In the patients at the end of the study, a statistically significant decrease in systolic blood pressure was observed (127 mmHg, p 0.041) and the pro-inflammatory markers TNFα, IL-1β and IL6 (31.9 pg/mL, p 0.012, 31.9 pg/mL, p 0.012, and 3.5 pg/mL, p 0.017 respectively) and glycaemia increase (157.5 mg/dL, p 0.036). Conclusions: the medium-term consumption of a compote based on guava, passion fruit, cinnamon and flaxseed oil improves systolic blood pressure and the proinflammatory markers TNFα, IL-1β and IL6 in diabetic and hypertensive patients.
OPTIMIZATION OF ULTRASOUND ASSISTED EXTRACTION OF POLYPHENOLS IN COCOA BEANS
Authors: Fajardo Daza Jonny Ariel , Herrera Ruales Frank Carlos , Ibarra Cabrera Carol Andrea 
Published: August 2020

Background: The determination of polyphenols in cocoa beans allows the establishing of antioxidant properties of great benefit to this product. Objectives: Optimization of the ultrasound-assisted extraction method to determine the content of polyphenols in cocoa beans. Methods: Two experiments design stages were carried out to optimize the ultrasound-assisted extraction process of polyphenols from the cocoa bean. In the first experiment design stage, the adequate extraction solvent was determined; for this purpose, five types of solvents were evaluated through a completely random design unrestricted (CRD). In the second experiment stage, a central composite design 22 + star point (with two central points) was used, which was evaluated using the response surface methodology to determine the influence of the temperature, time, and solute / solvent ratio. Results: The experiment found that acetone: water: acetic acid (70: 29.5: 0.5) mixture, leads to a greater amount of total extracted phenols measured for the Folin-Ciocalteu method. Analysis of variance (ANOVA) found that six significant effects that influence the response variable (total phenols extracted). The main effects were of the three factors and three of their interactions. Conclusions: After the optimizing said factors, an optimal point was found: 39.3 °C oftemperature, 74.5 minutes, and 22.8 mL of solvent per gram of cocoa sample.
FAKTOR YANG MEMPENGARUHI STRATEGI BERTAHAN HIDUP PEREMPUAN PULAU DI DESA GEDUGAN, PULAU GILIGENTING, KABUPATEN SUMENEP
Authors: Wardani Ismi Aulil 
Published: August 2020

<p>Pendapatan adalah salah satu faktor yang mempengaruhi perempuan Pulau untuk melakukan strategi bertahan hidup. Tidak hanya itu, masih ada faktor lainnya yang mempengaruhi. Faktor-faktor tersebut terkumpul dalam modal aset rumah tangga, dimana masing-masing saling terkait dan ada pula faktor yang paling mendominasi diantara lainnya. Penelitian ini bertujuan untuk mengidentifikasi dan menganalisis faktor-faktor yang mempengaruhi strategi bertahan hidup yang ada di Desa Gedugan Pulau Giligenting dan menganalisis hubungan faktor-faktor yang mempengaruhi dengan strategi bertahan hidup perempuan pulau . Metode yang digunakan adalah analisis kuantitatif dengan menyebarkan kuisioner (<em>skala likert</em>), observasi dan wawancara. Metode pengambilan sampling yang digunakan adalah <em>random sampling </em>dengan <em>slovin. </em>Variabel yang digunakan dalam penelitian ini adalah modal finansial, modal sosial, modal alam, modal fisik dan modal manusia, sedangkan metode analisis yang digunakan adalah analisis faktor dan analisis regresi linear berganda. Hasil penelitian menunjukkan bahwa faktor yang paling mendominasi dan paling berpengaruh tehadap strategi bertahan hidup Perempuan Pulau adalah modal finansial.</p><p> </p><p><em>I</em><em>ncome is one of the factors that influence Island women to carry out a survival strategy. Not only that, there are still other factors that influence. These factors are collected in household asset capital, each of which is interrelated and there is also a factor that is most dominating among others. This study aims to identify and analyze the factors that influence the survival strategy in Gedugan Village, Giligenting Island and analyze the relationship between the factors that influence the survival strategy of island women. The method used is quantitative analysis by distributing questionnaires (Likert scale), observation and interviews. The sampling method used was random sampling with Slovin. The variables used in this study are financial capital, social capital, natural capital, physical capital and human capital, while the analytical method used is factor analysis and multiple linear regression analysis. The results showed that the most dominant and most influential factor on the survival strategy of Pulau Perempuan was financial capital.</em></p>
INOVASI MODEL BIOINDUSTRI BERBASIS SAGU SPESIFIK LOKASI DI PAPUA
Authors: Beding Petrus Alexander , Lewaherilla Niki 
Published: August 2020

<p align="justify"><strong><em>Abstrack :</em></strong> <em>The Sago Bioindustry Agriculture Model produces food raw materials in the form of flour, and sago sugar food ingredients and the use of sago waste into organic fertilizer. The results of the business analysis show that sago starch, sago sugar and fertilizer products provide benefits for increasing farmers' income and are feasible to be developed each with a business feasibility level of R / C sago flour R / C (2.44) efficiency level for venture capital 40 , 8%; sago sugar R / C value of 2.81 with an efficiency level of 22.6% and sago waste organic fertilizer value of R / C 1.3 with a level of business capital efficiency of 76%. The purpose of this research is to disseminate location-specific sago bioindustry technology innovation models in accordance with the SOP of quality sago flour production, sago-based food processing, and utilization of waste for fertilizer</em>.</p><p align="justify"><strong> </strong></p><p align="justify"><strong>Abstrak</strong><strong><em>:</em></strong> Model Pertanian Bioindustri sagu menghasilkan produk bahan baku pangan berupa tepung, dan bahan pangan gula sagu serta pemanfaatan limbah sagu menjadi pupuk organik. Adapun tujuan dari penelitian ini adalah untuk mendiseminasikan model inovasi teknologi bioindustri sagu spesifik lokasi sesuai dengan SOP produksi tepung sagu bermutu, pengolahan pangan berbasis sagu, dan pemanfaatan limbah untuk pupuk.<strong> </strong>Hasil analisis usaha menunjukan bahwa produk tepung sagu, gula sagu dan pupuk memberikan nilai manfaat bagi peningkatan pendapatan petani dan layak untuk dikembangkan masing-masing dengan tingkat kelayakan usaha R/C tepung sagu R/C (2,44) tingkat efisensi terhadap modal usaha 40,8%; gula sagu nilai R/C 2,81 dengan tingkat efisiensi 22,6% dan pupuk organik limbah sagu nilai R/C 1,3 dengan tingkat efisiensi modal usaha sebesar 76%. </p>
ANALISIS PENDAPATAN AGROINDUSTRI GULA KELAPA DI KECAMATAN TEMPULING KABUPATEN INDRAGIRI HILIR
Authors: Wibowo Dhany , Maharani Evy , Eliza Eliza 
Published: August 2020

<p align="justify"><strong><em>Abstract</em></strong><strong><em>: </em></strong><em>Indragiri Hilir districtis is one of the main coconut-producer districts with a total production of up to 359,397 tons in Riau Province. This study aims to analyze the profit of coconut sugar agro-industry producer. The study was conducted in Karya Tunas Jaya village, Tempuling sub-district, Indragiri Hilir district. This location was chosen due to this village has a lot of hybrid coconut plantations and which are still active in processing downstream coconut sugar industry. This research was conducted for 6 months. To answer the research objectives used income analysis and return to cost ratio. The results showed that to produce a coconut sugar had to go through a long process, starting from collecting raw materials to molding and cooling coconut sugar. The average total processing cost of coconut sugar producer </em><em>was</em><em> Rp. 3,960,040.86/month and coconut sugar agro-industry producer profit </em><em>was</em><em> Rp. 4,845,866.67. Furthermore, the R/C ratio index of palm sugar agro-industry producer was 1.23 with an average profit of Rp. 885,825.80.</em><em></em></p><p align="justify"> </p><p align="justify"><strong>Abstrak</strong><strong>: </strong>Kabupaten Indragiri Hilir termasuk kabupaten penghasil kelapa peringkat pertama dengan jumlah produksi mencapai 359.397 ton di Provinsi Riau (BPS Provinsi Riau, 2018). Penelitian ini bertujuan untuk menganalisis keuntungan pengrajin agroindustri gula kelapa. Penelitian dilakukan di Kecamatan Tempuling Kabupaten Indragiri Hilir dan dipilih Desa Karya Tunas Jaya. Pemilihan lokasi ini dilakukan dengan sengaja dengan pertimbangan bahwa di lokasi ini merupakan desa yang banyak terdapat perkebunan kelapa hibrida dan yang masih aktif dalam pengolahan industri hilir gula kelapa. Penlitian ini dilakukan selama 6 bulan. Untuk menjawab tujuan penelitian digunakan analisis keuntungan dan efisiensis usaha agroindustri gula kelapa. Hasil penelitian menunjukan untuk menghasilkan gula kelapa harus melalui proses yang panjang, proses tersebut mulai dari pengumpulan bahan baku sampai pencetakan dan pendinginan gula kelapa. Rata-rata total biaya pengolahan pengrajin gula kelapa sebesar Rp. 3.960.040,86/bulan dan diperoleh keuntungan pengrajin agroindustri gula kelapa Rp. 4.845.866,67. Selanjutnya indeks rasio R/C pelaku usaha agroindustri gula kelapa sebesar 1,23 dengan rata rata keuntungan sebesar Rp 885.825,80. </p>
TEKNOLOGI EKSISTING USAHA TERNAK SAPI KELOMPOK TANI KARYA BERSAMA PADA PENDAMPINGAN PENGEMBANGAN KAWASAN PETERNAKAN KABUPATEN JAYAPURA
Authors: Beding Petrus Alexander , Tiro Batseba M.W. , Dominanto Ghalih P 
Published: August 2020

<p class="pre" align="justify"><strong><em><span>Abstract:</span></em></strong><em><span> </span></em><em><span>Jayapura is one of </span></em><em><span>regencie</span></em><em><span>s in Papua which is designated as development of breeding area of beef cattle commodities. This study aims to present data and information </span></em><em><span>about </span></em><em><span>the profile of beef cattle farms in the Karya Bersama Farmer Group, Namblong </span></em><em><span>d</span></em><em><span>istrict, Jayapura </span></em><em><span>regency </span></em><em><span>as the location for assisting the development of breeding area of beef cattle commodities. Data collection were conducted by survey and interview to 24 farme</span></em><em><span>rs</span></em><em><span> at Kelompok Tani Karya Bersama that strengthened by F</span></em><em><span>ocus </span></em><em><span>G</span></em><em><span>roup </span></em><em><span>D</span></em><em><span>iscussion</span></em><em><span>. The demonstration plot was carried out by introducing forage processing technology into silage and fermented straw as well as additional feed (bran) and observing the level of livestock reproduction. The results showed that the level of productivity of cattle is still relatively low, where calving interval is long (18-24 months), high S/C value (2 - 4), low birth weight (15-18 kg) and changes in body weight 0.1-0.2 kg/head/day. However, the assistance of technology can improve the productivity of cattle. </span></em><em></em></p><p class="pre" align="justify"> </p><p align="justify"><strong>Abstrak: </strong>Kabupaten Jayapura merupakan salah satu kabupaten di Papua yang ditetapkan sebagai pengembangan kawasan peternakan komoditas sapi potong. Kajian ini bertujuan untuk menyajikan data dan informasi mengenai profil usaha ternak sapi sapi potong pada kelompok tani Karya Bersama, Distrik Namblong, Kabupaten Jayapura sebagai lokasi pendampingan pengembangan kawasan peternakan komoditas sapi potong. Metode pengumpulan data dilakukan melalui survei dan wawancara langsung menggunakan kuisioner semi-struktur terhadap 24 responden peternak pada kelompok tani Karya Bersama dan dipertajam dengan <em>Focus Group Discussion</em> (FGD). Kegiatan demplot dilakukan dengan mengintroduksi teknologi pengolahan hijauan menjadi silase dan jerami fermentasi serta pakan tambahan (dedak) dan dilakukan pengamatan terhadap tingkat reproduksi ternak. Hasil kajian menunjukkan tingkat produktivitas ternak sapi masih tergolong rendah, dimana calving interval cukup panjang (18 – 24 bulan), nilai S/C tinggi (2 - 4), bobot lahir rendah (15 – 18 kg) serta perubahan bobot badan induk 0,1-0,2 kg/ekor/hari. Namun dengan adanya pendampingan teknologi dapat memperbaiki kinerja produktivitas ternak sapi. </p>