bluuebunny/crossref_metadata_2025_split huggingface dataset:
miR-200a-3p predicts prognosis and inhibits bladder cancer cell proliferation by targeting STAT4
Authors: Li Ming , Li Jie , Ye Chaoyang , Wu Weiwu , Cheng Yi 
Published: December 2019

IntroductionSTAT4 is a transcriptional regulator that has been reported to have oncogenic activities in various cancers. In our study, the posttranscriptional regulatory effect of miR-200a-3p on STAT4 and the prognostic significance of miR-200a-3p and STAT4 were evaluated in bladder cancer (BCa).Material and methodsProliferation and apoptosis of BCa cell lines were monitored using CCK-8 and Annexin V-FITC assays, respectively. Gene and protein expression levels in BCa tissues and cells were detected using RT-qPCR and western blotting, respectively.ResultsSignificant downregulation of miR-200a-3p and upregulation of STAT4 were observed in BCa tissues and cells compared with the corresponding non-tumor adjacent tissues. Both STAT4 and miR-200a-3p were validated as independent prognostic indicators in sixty-nine BCa patients for predicting overall survival and disease-free survival. In vitro experimental analyses revealed that knockdown of STAT4 repressed BCa cell growth and elevated cell apoptosis. Molecular interactive analysis revealed STAT4 as a direct target of miR-200a-3p, which could suppress STAT4 protein expression by posttranscriptional repression. Cotransfection of miR-200a-3p mimics and STAT4 overexpression plasmids into BCa cells demonstrated that the antineoplastic activities of miR-200a-3p in vitro were neutralized by overexpressed STAT4.ConclusionsThe miR-200a-3p/STAT4 signaling cascade plays an important role in the progression of BCa, which provides a new promising target for targeted BCa therapies.
Manual strangulation of the uterine isthmus after placental removal to reduce blood loss during cesarean section
Authors: Cilingir Isil , Karahasanoglu Ayse , Deregozu Aysegul , Ozdemir Mucize , Yazicioglu Fehmi 
Published: December 2019

IntroductionThis study aimed to evaluate the effect of manual strangulation of the uterine isthmus on the amount of blood loss during cesarean section.Material and methodsThis is a prospective randomized controlled trial. A total of 118 participants were enrolled in the study. Manual strangulation of the uterine isthmus just after placental removal was performed during cesarean section in group I (n = 57; the strangulation group). Strangulation was not performed in group II (n = 61; the control group). Preoperative and postoperative venous blood hemoglobin, capillary hemoglobin, and absorbed blood levels during the operation were compared between the two groups.ResultsThe median age of the patients was 28.5 (19–41). The median body
mass index of the patients in the study was 27 (21–42). There were no
significant differences in the demographic characteristics of the patients
between the groups. The median difference between the preoperative and
postoperative 4–6 h capillary hemoglobin values was significantly lower in
the strangulation group (2.0 (0–9)) than in the control group (3.0 (0–8)).
The amount of absorbed blood during the operation was also significantly
lower in the strangulation group (164.5 ml (69–1310)) than in the control
group (230 ml (35–3223)).ConclusionsManual uterine strangulation of the uterine isthmus immediately after the removal of the placenta may induce a 30% decrease in blood loss during cesarean section.
Tingling hand: magnetic resonance imaging of median nerve pathologies within the carpal tunnel
Authors: Kumari Ashwini , Singh Sapna , Garg Anju , Prakash Anjali , Sural Sumit 
Published: December 2019

Compressive neuropathy of the median nerve at the level of the carpal tunnel, known as carpal tunnel syndrome, is the most common entrapment neuropathy, affecting about 0.1-1% of the general population. Magnetic resonance reliably imaged the flexor retinaculum and carpal bones and thus defined the borders of the carpal tunnel. In all cases the median nerve was seen as an ovoid structure of moderate signal intensity and was easily distinguished from the flexor tendons of the hands running in the carpal tunnel. Magnetic resonance imaging (MRI) serves as an extremely useful tool for evaluation of primary nerve pathologies and for the assessment of space-occupying lesions leading to its compression. We present a pictorial review of the MRI findings in the multitude of pathologies implicated in the causation of carpal tunnel syndrome. All the images were obtained from the Department of Radiodiagnosis in our own institution.
Assistência de enfermagem frente aos fatores de risco para infecção urinária em mulheres
Authors: Melchior Anne Arielly 
Published: December 2019

Resumo – Objetivo: identificar os fatores de risco na infecção urinária em mulheres; Descrever a assistência de enfermagem frente a infecção urinária. Metodologia: estudo do tipo exploratório, bibligráfico com análise integrativa, qualitativa da literatura disponível em bibliotecas convencionais e virtuais. Resultados: identificou-se a Infecção urinária pode ser definida como colonização bacteriana da urina, que resulta em infecção das estruturas do aparelho urinário – do rim ao meato uretral. Pode-se aparecer clinicamente de várias formas, dependendo do setor afetado do aparelho urinário e a intensidade dessas manifestações também será variável, de acordo com fatores associados. A partir da identificação dos fatores de risco, é possível analisa-los e identificar quais são os mais predisponentes ao aumento de ITUs em mulheres e como poderão ser pensadas ações de promoção à saúde por meio de práticas educativas. A qualidade da assistência de Enfermagem vem sendo discutida e compartilhada há algum tempo, especialmente, em decorrência da crescente conscientização de que ela é um requisito fundamental à sobrevivência econômica das instituições de saúde, além de ser uma responsabilidade ética, profissional e social. Uma maneira de precaução é por meio da avaliação da qualidade das práticas assistenciais pela formulação de indicadores clínicos. Considerações finais: É necessário desenvolver pesquisas clínicas sobre o tratamento de infecção urinária feito por enfermeiros, apontando o provimento de evidências científicas para o embasamento dessa prática, uma vez que essa é uma promissora área de atuação do enfermeiro.

Palavras-chave: Enfermagem, Assistência, Infecção Urinária, Fatores de risco e Mulheres.
Rhetorical Hegemony: Transactional Ontologies and the Reinvention of Material Infrastructures
Authors: Chaput Catherine , Hanan Joshua S. 
Published: December 2019

ABSTRACTThis article proposes rhetorical hegemony as a new materialist intervention into the production of alternative political economic futures. It problematizes contemporary theories of hegemony that assert affect as beyond rhetorical engagement, suggesting that these accounts fail to produce viable political economic alternatives because they use, but do not reinvent, the prevailing affective relations. Turning to and extending Foucault's middle and late work to forge a different model, the article discusses rhetorical hegemony as the entangled relationships between materiality and power. In conversation with other contemporary theories, it argues for a practice of rhetorical hegemony that materially recapacitates energetic potential and, consequently, the milieu. The article ends by outlining the rhetorical, political, and intellectual implications of this shift.
Diálogos entre a função arquivística de avaliação e a representação da informação
Authors: Schwinden Lehmkuhl Camila , Melo Mintegui Evelin , Leite da Silva Eva Cristina , Brascher Marisa 
Published: December 2019

Introdução: Partindo das possibilidades de relacionamento entre as diferentes disciplinas que trabalham com a informação, e considerando a virada informacional da Arquivística em detrimento do foco nos documentos ser transferido para a informação orgânica, novos diálogos estão sendo feitos, por exemplo, entre a Arquivística e a Organização do Conhecimento. O fazer arquivístico calcado em funções arquivísticas como descrição e classificação já têm sido trabalhadas dentro da perspectiva da Organização do Conhecimento, enquanto formas de Representação da Informação. Objetivos: Procurando demonstrar que esses diálogos se estendem para além dessas duas funções, o presente artigo busca demonstrar tal relação entre a representação da informação e a função de avaliação arquivística, procurando relacioná-la com distintas abordagens do processo de avaliação, como a norma de descrição de funções do Conselho Internacional de Arquivos (International Standard for Describing Functions) e o modelo de avaliação documental proposto por Hernandéz Oliveira e Moro Cabero (2002). Como objetivos específicos procuram-se contextualizar as áreas de Organização e Representação do Conhecimento/Informação e a Arquivística; definir a função arquivística de avaliação e algumas de suas abordagens; e identificar, a partir da referida norma e o modelo de aplicação de avaliação proposto, possíveis diálogos entre a Organização e Representação da Informação e a função arquivística de avaliação. Metodologia: A metodologia aplicada se constitui de análise bibliográfica. Resultados: Os resultado­­s se pautaram no estudo sobre o processo de avaliação na visão de autores utilizados no referencial teórico, além da análise perante a norma citada e o modelo avaliativo. Considerações: Foi possível identificar ao final da análise que há pontos de intersecção entre a avaliação arquivística e a organização e representação da informação.
Las TIC en la atención a la diversidad educativa: el caso de la Comunidad Autónoma Vasca
Authors: Ochoa-Aizpurua Aguirre Begoña , Correa-Gorospe José Miguel , Gutiérrez-Cabello Barragán Aingeru 
Published: December 2019

El propósito de este artículo es el de acercarnos a las políticas educativas que desde la Consejería de Educación del Gobierno Vasco sostienen la propuesta de impulsar el desarrollo de una escuela inclusiva. Nuestra mirada se centra en el recorrido de estas políticas a lo largo de los últimos diez años. Mediante la identificación y selección de documentos de la Consejería de Educación, de acceso público, enfocamos el análisis en el papel que se designa en las mismas a las Tecnologías de la Información y la Comunicación, en una apuesta clara por trabajar la integración social del alumnado más vulnerable en la Etapa de Educación Primaria. Dos experiencias nos sirven para poner en valor el papel que las tecnologías digitales pueden tener en la integración de los colectivos más desfavorecidos. Se puede avanzar que el resultado es paradójico, al constatarse la falta de vinculación de las tecnologías de la información y la comunicación, con la mayoría de estas iniciativas de integración social, aunque institucionalmente se reconoce su valor en muchos otros documentos institucionales.
The purpose of this article is to approach the educational policies that from the Ministry of Education of the Basque Government support the proposal to promote the development of an inclusive school. Our focus is on the path of these policies over the past ten years. Through the identification and selection of documents of the Ministry of Education, public access, we focus the analysis on the role that is designated in them to Information and Communication Technologies, in a clear commitment to work the social integration of students most vulnerable in the Primary Education Stage. Two experiences help us to value the role that digital technologies can play in the integration of the most disadvantaged groups. It is possible to advance that the result is paradoxical, when the lack of links between information and communication technologies is found, with the majority of these social integration initiatives, although their value is institutionally recognized in many other institutional documents.
Reseña del libro “Los MOOC en la crisis de la Educación Universitaria. Docencia, diseño y aprendizaje”, de Miguel Zapata Ros
Authors: Steffens Karl 
Published: December 2019

Karl Steffens reseña este libro, dice que es una colección de 16 ensayos que Miguel Zapata-Ros (2014) publicó entre 2011 y 2014 como posts y artículos sobre MOOC. En su obra, el tema de los MOOC está relacionado con la situación en la Universidad que el autor describe como una crisis. Según él, es imprescindible que cambie el paradigma de la educación superior para resolver esta crisis. Mientras que el paradigma todavía existente supone una educación basada en estándares (unidad de lugar, de situación, de edad), el nuevo paradigma propone una educación basada en logros individuales. La tecnología permite un tratamiento personalizado y provee una potente analítica de aprendizaje que se puede aplicar a los procesos de enseñanza y en el aprendizaje. Al mismo tiempo, el nuevo paradigma destaca la importancia de una pedagogía de ayuda, una teoría de aprendizaje adecuada para explicar los procesos de aprender en entornos potenciados por las tecnologías digitales, de una teoría de instrucción basada en los principios teóricos que rigen el aprendizaje y en las informaciones que nos pueden suministrar las analíticas de aprendizaje. Todas estas consideraciones constituyen el trasfondo para la discusión del papel que los MOOC están jugando en la universidad y en su desarrollo.
El libro está dirigido a profesores, tutores y estudiantes de la universidad. Les ofrece muchas informaciones sobre el tema de los MOOC, su desarrollo y el papel que juegan en la enseñanza y en el aprendizaje universitario. Muestra que es un tema que tiene una gran variedad de aspectos. Al mismo tiempo, el autor ofrece una perspectiva crítica y propone un modelo de cursos abiertos y en línea, junto con una guía para diseñar e implementar cursos de este tipo. Es un libro que une consideraciones pedagógicas como teorías de aprendizaje y de instrucción con propuestas prácticas. Es el libro, de un experto en el campo del uso de las tecnologías digitales en la educación, dedicado a la idea de que estas tecnologías deberían empoderar a los estudiantes a mejorar su aprendizaje, ayudar a los profesores a mejorar su enseñanza y facilitar la interacción intercultural entre ambos grupos.
Cooperatives and Social Capital: A Theoretically-Grounded Approach
Authors: Spognardi Andres 
Published: December 2019

Social capital is widely regarded as a collective resource with positive effects on the economic performance of cooperatives. This conclusion is based on the implicit assumption that social interactions between cooperative members would inexorably lead to the development of networks, norms and trust. This paper challenges the validity of this assumption. Conceptualizing social capital as a resource of the individual, it is argued that the interactions between cooperative members may lead to the establishment of a variety of complex social ties, some of which can negatively affect the economic performance of the organization. To illustrate this argument, the paper presents an exploratory case study of a small, manufacturing worker cooperative. Drawing on ethnographic techniques, the study identifies four organizational dynamics which are presumably affected by social capital: (1) the rule of surplus distribution; (2) the style of leadership; (3) the mechanisms of control; and (4) the criteria for recruiting and evaluating new members.
¿Podría estar contribuyendo el cooperativismo a fijar la población en el territorio de Andalucía?
Authors: Valiente Palma Lidia 
Published: December 2019

En Andalucía las zonas rurales presentan marcadas desventajas frente a las urbanas, como son la falta de infraestructura, la escasez de servicios básicos o la falta de dinámicas económicas que provocan éxodo rural, entre otras, lo que genera desequilibrios territoriales en la región. Este éxodo rural, a su vez, influye como limitador de la generación de estas dinámicas, provocando un creciente envejecimiento de la población y mermando las oportunidades de desarrollo del territorio. Ante esta problemática, las cooperativas pueden tener un papel significativo por su capacidad para fijar la población en los territorios. A partir de lo anterior, el objetivo del presente trabajo consiste en determinar si las sociedades cooperativas en Andalucía podrían estar contribuyendo a mantener la población en el territorio, sobre todo rurales, en mayor grado que las empresas mercantiles. Para ello, se realizan análisis exploratorios y de regresiones espaciales al objeto de identificar si un mayor peso de cooperativas o de empresas mercantiles , a nivel municipal, se traduce en una menor tasa de emigraciones. Entre los resultados destaca que existen indicios acerca de que el cooperativismo podría estar suponiendo una oportunidad para evitar las emigraciones de mujeres y jóvenes en los territorios rurales.
Amino acids and acylcarnitine production by Chlorella vulgaris and Chlorella sorokiniana microalgae from wastewater culture
Authors: Ballesteros-Torres Juan M. , Samaniego-Moreno Luis , Gomez-Flores Ricardo , Tamez-Guerra Reyes S. , Rodríguez-Padilla Cristina , Tamez-Guerra Patricia 
Published: December 2019

Background
Microalgae are a widely distributed group of prokaryotic and eukaryotic photosynthetic microorganisms that use a number of substances present in wastewater to produce a variety of biotechnological and nutritional biomolecules.

Methods
Production ofamino acids and acylcarnitine by Chlorella vulgaris and Chlorella sorokiniana was determined after 13 d of culture in wastewater, under various culture conditions. Wastewater was collected from “La Encantada” stream, located in Saltillo, Coahuila, Mexico. Microalgae was cultured at 23°C and natural day light, including the use of the following conditions: (1) extra light (12:12 light:dark cycles, 1,380 lumens), (2) agitation (130 rpm), and (3) both conditions, until exponential phase. Supernatant products were then analyzed by liquid chromatograph coupled to mass spectrometry. In addition, metabolomic profiles related to growing conditions were evaluated.

Results
Amino acids and acylcarnitine production by C. sorokiniana and C. vulgaris resulted in higher Ala and Leu concentrations by C. vulgaris compared with control, where control produced Gly and Pro in higher amounts compared with C. sorokiniana. Tyr, Phe, Val, and Cit were detected in lower amounts under light and shaking culture conditions. High concentrations of C0 acylcarnitines were produced by both microalgae compared with control, where C. sorokiniana production was independent of culture conditions, whereas C. vulgaris one was stimulated by shaking. C4 production was higher by C. sorokiniana compared with control. Furthermore, C4, C6DC, C14:1, C14:2, and C18:1OH production by microalga was low in all culture conditions.

Conclusion
Microalgae produced essential amino acids and nutritionally important carnitines from wastewater. In addition, C. sorokiniana biomass has higher potential as animal nutrient supplement, as compared with that of C. vulgaris.
Application of Gold Nanostructures in Biomedicine
Authors: Yu Qian , Liu Maosong , Jiang Yinhua , Li Henan , Zhang Jianming 
Published: November 2019

Abstract
Today, nanomaterials have been considered as highly promising functional materials for various applications, impacting virtually all the fields of science and technologies. Functional nanoparticles (NPs), as one of the most important nanomaterials, are playing significantly important roles in some emerging research topics, such as biomedicine and biosensing. Among numerous NPs, gold NPs (AuNPs) with diverse shapes, such as rods, shells, and cages, have attracted increasing attention due to their unique properties of biocompatibility, absorption/scattering, and facile conjugation with a large variety of biomolecules. Recent advances in synthetic chemistry render the fabrication of AuNPs with precise control over physicochemical and optical properties, which are highly desired for specific clinical or biological applications, leading to remarkable achievements in the research field of biology and medicine. In this article, we briefly summarize the preparation of the AuNPs and their most recent advances in biology and medicine.
Programmable Hierarchical Kirigami
Authors: An Ning , Domel August G. , Zhou Jinxiong , Rafsanjani Ahmad , Bertoldi Katia 
Published: November 2019

AbstractKirigami—the Japanese art of cutting paper—has recently inspired the design of highly stretchable and morphable mechanical metamaterials that can be easily realized by embedding an array of cuts into a sheet. This study focuses on thin plastic sheets perforated with a hierarchical pattern of cuts arranged to form an array of hinged squares. It is shown that by tuning the geometric parameters of this hierarchy as well as thickness and material response of the sheets not only a variety of different buckling‐induced 3D deformation patterns can be triggered, but also the stress–strain response of the surface can be effectively programmed. Finally, it is shown that when multiple hierarchical patterns are brought together to create one combined heterogeneous surface, the mechanical response can be further tuned and information can be encrypted into and read out via the applied mechanical deformation.
Wireless Monitoring Using a Stretchable and Transparent Sensor Sheet Containing Metal Nanowires
Authors: Araki Teppei , Uemura Takafumi , Yoshimoto Shusuke , Takemoto Ashuya , Noda Yuki , Izumi Shintaro , Sekitani Tsuyoshi 
Published: November 2019

AbstractMechanically and visually imperceptible sensor sheets integrated with lightweight wireless loggers are employed in ultimate flexible hybrid electronics (FHE) to reduce vital stress/nervousness and monitor natural biosignal responses. The key technologies and applications for conceptual sensor system fabrication are reported, as exemplified by the use of a stretchable sensor sheet completely conforming to an individual's body surface to realize a low‐noise wireless monitoring system (<1 µV) that can be attached to the human forehead for recording electroencephalograms. The above system can discriminate between Alzheimer's disease and the healthy state, thus offering a rapid in‐home brain diagnosis possibility. Moreover, the introduction of metal nanowires to improve the transparency of the biocompatible sensor sheet allows one to wirelessly acquire electrocorticograms of nonhuman primates and simultaneously offers optogenetic stimulation such as toward‐the‐brain–machine interface under free movement. Also discussed are effective methods of improving electrical reliability, biocompatibility, miniaturization, etc., for metal nanowire based tracks and exploring the use of an organic amplifier as an important component to realize a flexible active probe with a high signal‐to‐noise ratio. Overall, ultimate FHE technologies are demonstrated to achieve efficient closed‐loop systems for healthcare management, medical diagnostics, and preclinical studies in neuroscience and neuroengineering.