bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on Teaching Reform of Civil Engineering Construction Course under the Background of New Engineering
Authors: Pan Chonggen , Chen Keyu , Shen Xinyuan 
Published: July 2020

Abstract
“New Engineering” is an engineering education reform carried out in China under the background of a new round of industrial technology revolution, which puts forward higher requirements for students’ engineering practical ability and innovative thinking. Civil engineering construction course is one of the important required modules for civil engineering majors, which has the characteristics of complex course content, lack of connection between chapters, and less practical knowledge. The traditional teaching model cannot effectively adapt to the curriculum, leading students to lack of practical ability, interest and other problems. Starting with the educational concept of “New Engineering”, this paper analyzes the problems in the current teaching process of civil engineering construction course, and puts forward the corresponding teaching reform measures to provide reference.
Research on traffic organization improvement scheme of highway opposite side weaving area based on VISSIM simulation
Authors: Hao S Y , Zhao N L , Wu K M , Li J H , Jiao C W 
Published: July 2020

Abstract
Under the premise of configuration and length limitation, how to optimize the weaving area based on the existing basic conditions of the road is an important issue. In this paper, a case study of one interchange was presented to explore a traffic organization improvement scheme in opposite side weaving area with limited length. Based on VISSIM simulation, the traffic operation of the current scheme and the improvement scheme in the weaving area were analysed in the coming years. The results showed that before the “Forward 4” with a small flow, there was no significant comparison between the parameters of the current scheme and the improvement scheme. However, after “Forward 4” under the impact of large traffic flow, the section volume in the weaving area increased by 10%-26%, the running speed increased by 2.1-2.6 times, the number of vehicle lane changes decreased by 43-58%. Compared with the current scheme, the traffic efficiency of the improvement scheme was significantly improved. The research results could provide guidance and reference for this study case and similar projects.
Modernity Expression of Traditional Regional Elements of Yunyang in The Context of Urban Renewal
Authors: Liu Sijia 
Published: July 2020

Abstract
In recent years, with the rapid development of China’s urbanization, the newly built buildings increasingly ignore the traditional regional elements. Yunyang, as an immigrant city, has experienced the impact and integration of multiple cultures in history, and has unique cultural deposits and spiritual connotations. In order to inherit the traditional regional culture, it is necessary to find a new way to express the traditional regional elements in modern architecture. This paper attempts to analyse the existing practices in Yunyang and the whole country and find out the new methods of modernity expression of traditional regional elements in architecture.
Analysis and Research on the Temporal and Spatial Changes of Land Use in Zhaozhou County Based on Geo-information TUPU
Authors: chong Du , yueyang Liu , xianfeng Guo , chenglong Xu 
Published: July 2020

Abstract
Geo-information maps use simple language and graphics to express complex geographical phenomena, and provide an effective means for spatial analysis of land use. This article uses Landsat 8 OLI in Zhaozhou County in 2013 and 2020 as the main data source, with the support of RS and GIS technology to process the land use data in Zhaozhou County, conduct spatial analysis and explore its temporal and spatial changes. The results show that: from the current land use map, Zhaozhou County is dominated by cultivated land, from the analysis of the land use change TUPU, we can see that grassland and unused land are increasing, and the mainly transfer map is from cultivated land to unused land and cultivated land →grassland with a transfer area of 354.22km2; the largest new grassland area was from 2013 to 2010, mainly from the transfer of cultivated land, forestland and construction land. Overall, the land use pattern tended to be stable from 2013 to 2020.
2D Hydraulic modelling of the main urban area of Chongqing, Part 2: model validation and application
Authors: Ge Hua , Deng Chunyan 
Published: July 2020

Abstract
The main urban area of Chongqing reach is located at the fluctuating backwater area of the Three Gorges reservoi. The operation of the reservoir has a significant impact on the erosion and deposition of this reach, not only the total amount and scope, but also the period in one year. In this paper, a two-dimensional hydraulic mathematical model was built in order to simulate the sediment deposition in this reach. The calibration was carried out by using some series of field data to provide the accurate parameters, such as roughness, sediment capacity. And values of roughness, coefficient and index of sediment carrying capacity, saturation coefficient of deposition and erosion are suggested after the calibration.
Research on Planning and Layout of Electric Vehicle Public Charging Piles in Historical and Cultural Street Based on Big Data
Authors: Zou Han , Xiong Yue , Hu Xiao 
Published: July 2020

Abstract
Nowadays, with the development and popularization of electric vehicles, electric vehicle charging pile has become an important green infrastructure in cities. The optimization of the layout of charging piles in the urban area has drawn the attention of more and more research groups. However, only a few of them concerned the distribution of piles in the historical distinct. In this paper, we proposed to use big data tools to obtain parking and electric parking space information, such as the parking lots, on-street parking spaces and plazas. We tried to transform them with the charging function. we also proposed a “P + W” mode, which takes advantage of the present parking lots and street parking area. We wanted to optimize the current layout and offer a new layout plan for further research and application.
Research on ideological security of college students based on GA-BP algorithm
Authors: Haiming Chen , Yang Cao , Xiwei Feng , Liqun Zhang 
Published: July 2020

Abstract
In order to evaluate the degree of ideological security of college students scientifically, a prediction model of ideological security of college students based on BP neural network optimized by genetic algorithm is proposed. The entropy method is used to determine the index weight and initial prediction results of the security model prediction. The genetic algorithm is used to optimize the weight and threshold of the BP neural network model, and an ideological and ideological security evaluation model for college students is constructed. The experimental results show that compared with the BP algorithm model, the average error of the improved GA-BP algorithm model is reduced by 12.11%, reaching 0.245%. It shows that the improved GA-BP model can predict the ideological security of college students.
Research on fused sorting based on logical regression in news recommendation system
Authors: Lijie Xing , Xiwei Feng , Haiming Chen , Ying Wang , Yue Zhang 
Published: July 2020

Abstract
A fusion sorting model based on logical regression is used to solve the problem of information overload in the news recommendation system and meet the personalized needs of users. First, the fusion sorting model is trained based on the article data and user data, and the original candidate news set is obtained by multi-channel recall method. Then the original candidate set is filtered by the fusion sorting model, and the recommendation list is generated. Finally, the experiment is carried out based on the Wuli News Recommendation System. Under the evaluation indexes of precision, recall and ILS, the fusion sorting model adopted significantly improves the recommendation ability of the system, and achieves the goal of making multiple single recommendation strategies make up for each other’s shortcomings.
Research on Coordinated Charging Control Strategy Load Optimization of Electric Vehicles in Residential Area
Authors: Wang Yingqiu , Zhang Jian , Li Lei , Zhang Jing , Liu Weidong , Li Dan , Liu Zhibin , Liu Yajing 
Published: July 2020

Abstract
For the power utilization load encountered in the construction of electric vehicles (EVs) charging facilities in residential area, the coordinated charging control strategy for EV charging loads is studied. Based on the utilization electric load model, EV model, and distribution network information model of the residential area during the EV user using, the minimizing the fluctuation of the EV users charging cost, utilization power load and EV charging load is established. It is verified by an EV coordinated charging residential area, the sliding recursive algorithm employed can realize peak-load shifting, which can effectively reduce the effect of EV charging peak load and move the power peak to the second half of the night.
Analysis on the application of media technology in museum exhibition
Authors: Yumei Han 
Published: July 2020

Abstract
Multimedia technology is now widely used in museum display and exhibition, which promotes the museum’s knowledge and interest. This paper introduces the application of multimedia technology in display and exhibition, and points out that in display and exhibition, we should also take a rational attitude towards the application of multimedia technology, and the selection of multimedia technology should be based on different exhibition types and exhibition themes.
On the construction of virtual museum
Authors: Yumei Han 
Published: July 2020

Abstract
The combination of virtual reality technology and museum is feasible and inevitable. Virtual reality technology can make effective use of digital resources and generate strong immersion interaction, which is perfectly consistent with the characteristics of modern social museum, and promotes the birth of virtual museum. There are certain principles and problems in the construction of virtual museum. These problems can be solved through personnel training, capital investment and institutional innovation.
1.3-µm passively mode-locked quantum dot lasers epitaxially grown on silicon: gain properties and optical feedback stabilization
Authors: Dong Bozhang , de Labriolle Xavier C , Liu Songtao , Dumont Mario , Huang Heming , Duan Jianan , Norman Justin C , Bowers John E , Grillot Frédéric 
Published: July 2020

Abstract
This work reports on an investigation of the optical feedback in an InAs/InGaAs passively mode-locked quantum dot (QD) laser epitaxially grown on silicon. Under the stably-resonant optical feedback condition, experiments demonstrate that the radio-frequency linewidth is narrowed whatever the bias voltage applied on the saturable absorber (SA) is; on the other hand, the effective linewidth enhancement factor of the device increases with the reverse bias voltage on the SA, hence it is observed that such an increase influences the mode-locking dynamic and the stability of device under optical feedback. This work gives insights for stabilizing epitaxial QD mode-locked lasers on silicon which is meaningful for their applications in future large-scale silicon electronic and photonic applications requiring low power consumption as well as for high-speed photonic analog-to-digital conversion, intrachip/interchip optical clock distribution and recovery.
Financial Strain and Suicide Attempts in a Nationally Representative Sample of US Adults
Authors: Elbogen Eric B , Lanier Megan , Montgomery Ann Elizabeth , Strickland Susan , Wagner H Ryan , Tsai Jack 
Published: July 2020

Abstract
Although research has identified many suicide risk factors, the relationship between financial strain and suicide has received less attention. Using data representative of the US adult population (n = 34,653) from wave 1 (2001–2002) and wave 2 (2004–2005) of the National Epidemiologic Survey on Alcohol and Related Conditions, we investigated the association between financial strain—financial debt/crisis, unemployment, past homelessness, and lower income—and subsequent suicide attempts and suicidal ideation. Multivariable logistic regression controlling for demographic and clinical covariates showed that cumulative financial strain was predictive of suicide attempts between waves 1 and 2 (odds ratio (OR) = 1.53, 95% confidence interval (CI): 1.32, 1.77). Wave 1 financial debt/crisis (OR = 1.58, 95% CI: 1.06, 2.34), unemployment (OR = 1.52, 95% CI: 1.10, 2.10), past homelessness (OR = 1.50, 95% CI: 1.03, 2.17), and lower income (OR = 1.51, 95% CI: 1.01, 2.25) were each associated with subsequent suicide attempts. Respondents endorsing these 4 financial-strain variables had 20 times higher predicted probability of attempting suicide compared with respondents endorsing none of these variables. Analyses yielded similar results examining suicidal ideation. Financial strain accumulated from multiple sources (debt, housing instability, unemployment, and low income) should be considered for optimal assessment, management, and prevention of suicide.
Do Inpatient Antimicrobial Stewardship Programs Help Us in the Battle Against Antimicrobial Resistance?
Authors: Tartof Sara Y , Chen Lie Hong , Tian Yun , Wei Rong , Im Theresa , Yu Kalvin , Rieg Gunter , Bider-Canfield Zoe , Wong Frances , Takhar Harpreet S , Qian Lei 
Published: July 2020

Abstract

Background
Antibiotic stewardship programs (ASPs) have demonstrated success at reducing costs, yet there is limited quality evidence of their effectiveness in reducing infections of high-profile drug-resistant organisms.

Methods
This retrospective, cohort study included all Kaiser Permanente Southern California (KPSC) members aged ≥18 years hospitalized in 9 KPSC hospitals from 1 January 2008 to 31 December 2016. We measured the impact of staggered ASP implementation on consumption of 18 ASP-targeted antibiotics using generalized linear mixed-effects models. We used multivariable generalized linear mixed-effects models to estimate the adjusted effect of an ASP on rates of infection with drug-resistant organisms. Analyses were adjusted for confounding by time, cluster effects, and patient- and hospital-level characteristics.

Results
We included 765 111 hospitalizations (288 257 pre-ASP, 476 854 post-ASP). By defined daily dose, we found a 6.1% (−7.5% to −4.7%) overall decrease antibiotic use post-ASP; by days of therapy, we detected a 4.3% (−5.4% to −3.1%) decrease in overall use of antibiotics. The number of prescriptions increased post-ASP (1.04 [1.03–1.05]). In adjusted analyses, we detected an overall increase in vancomycin-resistant enterococci infections post-ASP (1.37 [1.10–1.69]). We did not detect a change in the rates of extended-spectrum beta-lactamase, carbapenem-resistant Enterobacteriaceae, and multidrug-resistant Pseudomonas aeruginosa infections post-ASP.

Conclusions
ASPs with successful reductions in consumption of targeted antibiotics may not see changes in infection rates with antibiotic-resistant organisms in the 2 to 6 years post-implementation. There are likely differing timescales for reversion to susceptibility across organisms and antibiotics, and unintended consequences from compensatory prescribing may occur.
Mitochondrial DNA Damage and Brain Aging in Human Immunodeficiency Virus
Authors: Roca-Bayerri Carla , Robertson Fiona , Pyle Angela , Hudson Gavin , Payne Brendan A I 
Published: July 2020

Abstract

Background
Neurocognitive impairment (NCI) remains common in people living with human immunodeficiency virus (PLWH), despite suppressive antiretroviral therapy (ART), but the reasons remain incompletely understood. Mitochondrial dysfunction is a hallmark of aging and of neurodegenerative diseases. We hypothesized that human immunodeficiency virus (HIV) or ART may lead to mitochondrial abnormalities in the brain, thus contributing to NCI.

Methods
We studied postmortem frozen brain samples from 52 PLWH and 40 HIV-negative controls. Cellular mitochondrial DNA (mtDNA) content and levels of large-scale mtDNA deletions were measured by real-time polymerase chain reaction. Heteroplasmic mtDNA point mutations were quantified by deep sequencing (Illumina). Neurocognitive data were taken within 48 months antemortem.

Results
We observed a decrease in mtDNA content, an increase in the mtDNA “common deletion,” and an increase in mtDNA point mutations with age (all P &lt; .05). Each of these changes was exacerbated in HIV-positive cases compared with HIV-negative controls (all P &lt; .05). ART exposures, including nucleoside analogue reverse transcriptase inhibitors, were not associated with changes in mtDNA. The number of mtDNA point mutations was associated with low CD4/CD8 ratio (P = .04) and with NCI (global T-score, P = .007).

Conclusions
In people with predominantly advanced HIV infection, there is exacerbation of age-associated mtDNA damage. This change is driven by HIV per se rather than by ART toxicity and may contribute to NCI. These data suggest that mitochondrial dysfunction may be a mediator of adverse aging phenotypes in PLWH.
Often forgotten, transport modality to dialysis may be life-saving
Authors: Fernandez-Prado Raul , Gonzalez-Parra Emilio , Ortiz Alberto 
Published: July 2020

AbstractHaemodialysis patients commute to the dialysis facility thrice weekly, for a total of six trips per week. While nephrologists may think that how patients do this is up to them and their insurance companies, there is growing evidence that providing advice on how to commute to dialysis is part of an integrated care plan for dialysis patients. In this issue of Clinical Kidney Journal, two reports emphasize the importance of transport modality on dialysis patient well-being and even survival. Rincon et al. report on the epidemiology and clinical spectrum of coronavirus disease 2019 (COVID-19) in a Spanish haemodialysis unit. A key source of infection was related to access to healthcare or elderly care facilities. Indeed, healthcare transportation with future symptomatic [odds ratio (OR) = 3.33] or asymptomatic (OR = 4.73) COVID-19 patients increased the risk of infection. Working with transport providers to minimize cross-infection between patients during transport was one of the measures taken to stop disease transmission. Lessons learned from COVID-19 may also apply to influenza and other infections. In the second report, Yazawa et al. describe an association between transport modality to the dialysis facility and health-related quality of life (QOL) among haemodialysis patients in the Japanese Dialysis Outcomes and Practice Patterns study. These reports emphasize the need for nephrologists to understand how patients are transported to dialysis and how transport modality may be optimized to promote QOL and decrease potentially life-threatening complications.
Serum uromodulin is inversely associated with biomarkers of subclinical inflammation in the population-based KORA F4 study
Authors: Then Cornelia , Herder Christian , Then Holger , Thorand Barbara , Huth Cornelia , Heier Margit , Meisinger Christa , Peters Annette , Koenig Wolfgang , Rathmann Wolfgang , Roden Michael , Stumvoll Michael , Maalmi Haifa , Meitinger Thomas , Lechner Andreas , Scherberich Jürgen , Seissler Jochen 
Published: July 2020

Abstract

Background
Uromodulin is a kidney-specific glycoprotein synthesized in tubular cells of Henle’s loop exerting nephroprotective and immunomodulatory functions in the urinary tract. A small amount of uromodulin is also released into the systemic circulation, where its physiological role is unknown. Serum uromodulin (sUmod) has been associated with metabolic risk factors and with cardiovascular events and mortality, where these associations were partly stronger in men than in women. In this study, we investigated the associations of sUmod with biomarkers of subclinical inflammation in a population-based sample of women and men.

Methods
Associations of sUmod with 10 biomarkers of subclinical inflammation were assessed in 1065 participants of the Cooperative Health Research in the Region of Augsburg (KORA) F4 study aged 62–81 years using linear regression models adjusted for sex, age, body mass index, estimated glomerular filtration rate and diabetes. Analyses were performed in the total study sample and stratified by sex.

Results
sUmod was inversely associated with white blood cell count, high-sensitive C-reactive protein, interleukin (IL)-6, tumour necrosis factor-α, myeloperoxidase, superoxide dismutase-3, IL-1 receptor antagonist and IL-22 after multivariable adjustment and correction for multiple testing (P &lt; 0.001 for each observation). There was a trend towards a stronger association of sUmod with pro-inflammatory markers in men than in women, with a significant P for sex interaction (&lt;0.001) regarding the relation of sUmod with IL-6.

Conclusions
sUmod was inversely associated with biomarkers of subclinical inflammation in older participants of the KORA F4 study. The association of sUmod with IL-6 differed between women and men. Future research should focus on whether the immunomodulatory properties of sUmod are one explanation for the association of sUmod with cardiovascular outcomes and mortality.
NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli
Authors: Linna-Kuosmanen Suvi , Tomas Bosch Vanesa , Moreau Pierre R , Bouvy-Liivrand Maria , Niskanen Henri , Kansanen Emilia , Kivelä Annukka , Hartikainen Juha , Hippeläinen Mikko , Kokki Hannu , Tavi Pasi , Levonen Anna-Liisa , Kaikkonen Minna U 
Published: July 2020

Abstract

Aims
Oxidized phospholipids and microRNAs (miRNAs) are increasingly recognized to play a role in endothelial dysfunction driving atherosclerosis. NRF2 transcription factor is one of the key mediators of the effects of oxidized phospholipids, but the gene regulatory mechanisms underlying the process remain obscure. Here, we investigated the genome-wide effects of oxidized phospholipids on transcriptional gene regulation in human umbilical vein endothelial cells and aortic endothelial cells with a special focus on miRNAs.

Methods and results
We integrated data from HiC, ChIP-seq, ATAC-seq, GRO-seq, miRNA-seq, and RNA-seq to provide deeper understanding of the transcriptional mechanisms driven by NRF2 in response to oxidized phospholipids. We demonstrate that presence of NRF2 motif and its binding is more prominent in the vicinity of up-regulated transcripts and transcriptional initiation represents the most likely mechanism of action. We further identified NRF2 as a novel regulator of over 100 endothelial pri-miRNAs. Among these, we characterize two hub miRNAs miR-21-5p and miR-100-5p and demonstrate their opposing roles on mTOR, VEGFA, HIF1A, and MYC expressions. Finally, we provide evidence that the levels of miR-21-5p and miR-100-5p in exosomes are increased upon senescence and exhibit a trend to correlate with the severity of coronary artery disease.

Conclusion
Altogether, our analysis provides an integrative view into the regulation of transcription and miRNA function that could mediate the proatherogenic effects of oxidized phospholipids in endothelial cells.