bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 3-year Longitudinal Study of the Effects of Physical Activity and Sedentary Behaviors on Childhood Obesity in China: The Childhood Obesity Study in China Mega-Cities
Authors: Sun Xiaomin , Zhao Bingtong , Liu Jin , Wang Yun , Xu Fei , Wang Youfa , Xue Hong 
Published: June 2020

Abstract
Objectives: Examine school children’s physical activity (PA) and sedentary behaviors (SB) during 2015-2017 and study their effects on children’s weight status and their relevant gender differences in China. Methods: This open cohort study included students from 5 major cities (Beijing, Shanghai, Xi’an, Nanjing, and Chengdu) across China. Data were collected from students in 2015, 2016, and 2017 (n = 5,535) and from their parents and school personnel. Children’s weight, height, and waist circumference were measured. SB and PA factors were evaluated using questionnaires. Mixed effects models examined the relationship between weight status and PA/SB-associated factors using this longitudinal data. Results: These children had high rates of obesity (12.4%, 95% CI 11.6%-13.3%) and central obesity (28.1%, 95% CI 26.9%-29.3%) during 2015-2017. Boys were more likely to be obese (16.5% vs. 8.4%) and central obese (36.3% vs. 19.8%) and spent more time in screen viewing than girls (hours/week ± SD: 2015, 1.8 ± 2.5 vs. 1.5 ± 2.0; 2016, 2.0 ± 2.4 vs. 1.8 ± 2.5; 2017, 1.7 ± 2.3vs. 1.4 ± 2.1 hours/week). Those who walked ＜ 5 minutes on their average daily walk to school were more likely to be obese (OR: 1.96, 95% CI 1.03-3.73) than those who spent ≥ 15 minutes on walking to school. When stratified by gender, this higher risk was only observed in girls (OR: 3.01, 95% CI 1.09-8.35). Children who spent more time in screen viewing were more likely to be obese (OR: 1.13, 95% CI 1.06-1.21) and have central obesity (OR: 1.05, 95% CI 1.02-1.09). The association for obesity was consistent in boys and girls (boys, OR: 1.15, 95% CI 1.05-1.25; girls, OR: 1.12, 95% CI 1.00-1.24). Conclusions: More screen time and less active time were risk factors for developing obesity in urban Chinese children. The associations varied by gender.
Identification of an autophagy-related gene expression prognostic model in endometrial carcinoma patients
Authors: Jiang Pinping , Sun Wei , Shen Ningmei , Wang Qiang , Wang Shouyu , Fu Shilong 
Published: June 2020

Abstract
Background

Autophagy, as a lysosomal degradation pathway, has been reported to be involved in various pathologies, including cancer. However, the expression profiles of autophagy-related genes (ARGs) in endometrial cancer (EC) remain poorly understood.
Methods

In this study, we analyzed the expression of MRGs using The Cancer Genome Atlas (TCGA) data to screen differentially expressed MRGs (DE-MRGs) significantly correlated to EC patients’ prognosis. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of DE-MRGs were investigated. LASSO algorithm and Cox regression analysis were performed to select MRGs closely related to EC patients’ outcomes. A prognostic signature was developed and the efficacy were validated in part of and the entire TCGA EC cohort. Moreover, we developed a comprehensive nomogram including the risk model and clinical features to predict EC patients' survival probability.
Results

Ninety-four ARGs significantly dysregulated in EC samples compared with the normal control samples. Functional enrichment analysis showed these differentially expressed ARGs (DE-ARGs) were highly enriched in apoptosis, P53 signaling pathway, and various cancer development. Among the 94 DE-ARGs, we subsequently screen out four-ARGs closely related to EC patients outcomes, which are ERBB2, PTEN, TP73 and ARSA. Based on the expression and coefficiency of 4 DE-ARGs, we developed a prognostic signature and further validated its efficacy in part of and the entire TCGA EC cohort. The four ARGs signature was independent of other clinical features, and was proved to effectively distinguish high- or low-risk EC patients and predicted patients' OS accurately. Moreover, the nomogram showed the excellent consistency between the prediction and actual observation in terms of patients' 3- and 5-year survival rates.
Conclusions

It was suggested that the ARG prognostic model and the comprehensive nomogram may guide the precise outcome prediction and rational therapy in clinical practice.
Development and validation of a questionnaire to assess facilitators and barriers to physical activity for patients with rheumatoid arthritis, axial spondyloarthritis or psoriatic arthritis
Authors: DAVERGNE Thomas , Moe Rikke H , Fautrel Bruno , Gossec Laure 
Published: June 2020

Abstract
Objectives: The objective was to develop and validate a self-administered questionnaire to identify in people with Inflammatory arthritis (IA) Facilitators And Barriers to Physical activity (PA): the IFAB questionnaire. Methods: The development of the questionnaire included a systematic review of barriers and facilitators to PA to identify key themes, face validity assessment by 11 experts and cognitive debriefing with 14 patients. The psychometric properties of the questionnaire were assessed by convergent validity (Spearman correlation) against the modified Health Assessment Questionnaire (mHAQ), the Fear-Avoidance Beliefs Questionnaire subscale for PA and the Tampa Scale for Kinesiophobia, internal consistency (Cronbach α) in 63 IA patients with rheumatoid arthritis (RA), axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA). Reliability and feasibility were assessed in 32 IA patients. Results: The questionnaire comprises 10 items: 4 assessing either barriers or facilitators, 3 assessing barriers and 3 assessing facilitators. The items are related to: psychological status (N=6), social support (N=2), disease (N=1), environmental factors (N=1). In the validation study of 63 patients: 26 RA, 24 axSpA, 13 PsA; mean age 52.8 (standard deviation 16.5) years, mean disease duration 12.5 (12.3) years, 53% women. The questionnaire was correlated (r=0.24) with mHAQ. Internal consistency (Cronbach α 0.69) and reliability (interclass coefficient 0.79 [95% confidence interval 0.59; 0.88]) were satisfactory, as was feasibility (missing data 12%, mean completion time <5 minutes).Conclusion: The questionnaire allows the assessment of barriers and facilitators to PA in patients with IA. This questionnaire may guide targeted interventions to increase levels of PA in these patients.
The lncRNA-MALAT1/miR-126-5p Axis Promotes Growth and Metastasis of Gastric Cancer through Regulation of VEGFA
Authors: Hu Zhi-Li , Hu Yang-zhi , Li Qing , Liao Tian-you , Jiang Hai-ping 
Published: June 2020

Abstract
Background: It has been reported that reduction of miR-126 can promote the progression of gastric cancer (GC). However, the regulation of miR-126 in GC is still unclear. This study aims to explore the correlation between lncRNA MALAT1 and miR-126 in gastric cancer and disclose the underlying mechanisms.Methods: We analyzed the correlation of MALAT1 levels and clinical features by analysis of bioinformatic data and human samples. Then we down-regulate the expression of MALAT1 in AGS cells and examined the characteristics of cell proliferation, cycle, apoptosis, migration, invasion, and the effect on miR-126 as well as VEGFA and signaling pathway. In addition, we demonstrated the role of MALAT1/miR-126 axis in GC with dual-luciferase reporter gene assay and treatment of miR-126 inhibitor.Results: The expression of MALAT1 was higher in cancer tissues than para-cancer tissues. In addition, high MALAT1 level suggested greater malignancy and poorer prognosis. Down-regulating the expression of MALAT1 in AGS cells inhibited cell proliferation, migration, and invasion by targeting VEGFA, which is consistent with up-regulation of miR-126. According to dual-luciferase reporter gene assay and treatment of miR-126 inhibitor, we demonstrated that MALAT1 down-regulated miR-126 in GC, which leads to the up-regulation of VEGFA and activation of mTOR signaling pathway.Conclusions: MALAT1/miR-126 axis promotes growth and metastasis of gastric cancer through regulation of VEGFA via mTOR signaling pathway.Fund This article is supported by Science and Technology Funding Project of Hunan Province, China (No.2017SK4010)
Exploring the Effect of Problem Based Facilitatory Teaching Approach on Motivation to Learn in Nursing Education: A Quasi-Experimental Study of Nurse Students in Tanzania
Authors: Millanzi Walter Cleophace , Kibusi Stephen M. 
Published: June 2020

Abstract
Background: Currently, there has been a progressive shortage of not only the number of frontline healthcare providers but also a decline in the quality of nursing care. Reports about unethical and illegal practices, under standard care and malpractices are not uncommon around the globe. There is a growing concern to rethink the approaches on how nurses are prepared, explore, and test novel approaches for delivering the nursing curricula. This study tested the effect of Problem Based Facilitatory Teaching Approach on motivation to learn among nursing students in Tanzania, higher learning institutions. Methods: A pre-post test controlled quasi-experimental study of purposively selected 401 participants was conducted between February and June 2018. The Auditing Inventory developed by the researcher measured FPBE and Questionnaire titled Motivation to Learn Strategies in Nursing was adopted to measure the motivation to learn, respectively. Statistical Product for Service Solutions software program version 23 was use to perform analysis. Descriptive analysis was performed to analyze sociodemographic. The t-tests were performed to determine mean score differences of the levels of motivation to learn between groups. Regression analysis was performed to determine the association between variables. This study was not a clinical randomized controlled trial and thus it has not been identified in the title and no summary of trial design, methods, results, and conclusion. Results: Findings revealed that 65.8% of the study participants were males. The post-test results on Intrinsic motivation to learn indicated higher mean scores changes (p<0.01). Participants in an intervention group were 1.720 (AOR) times more likely to develop intrinsic motivation to learn than the control group (p<0.05). Moreover, FPBE was less times likely to enhance Extrinsic motivation to learn (AOR = 0.676, p>0.05) and Amotivation (AOR = 0.538, p>0.05) in learning among nurse students respectively respectively. Conclusion: FPBE had a positive effect on the intrinsic motivation to learn than conventional teaching pedagogy. Thus, FPBE has the potential to positively change the spectrum of nursing competency and quality of care. Recommendations were given based on the findings.
Surface Deformation Evolution in the Pearl River Delta Between 2006 and 2011 Estimated from the ALOS1/PALSAR
Authors: Li Genger , Feng Guangcai , Xiong Zhiqiang , Liu Qi , Xie Rongan , Zhu Xiaoling , Luo Shuran 
Published: June 2020

Abstract
This study monitors the land subsidence of the whole Pearl River Delta (PRD) (area: ~40,000 km2) in China using the ALOS1/PALSAR data (2006-2011) and the SBAS-InSAR method. We also analyze the relationship between the subsidence and the coastline change, river distribution, geological survey data as well as the geomorphology data. The results show that (1) the land subsidence with the average velocity of 50 mm/year occurred in the low elevation area in the front part of the delta and the coastal area; (2) the areas along rivers also suffered from surface subsidence, due to the fragile geological structure and frequent human interference; (3) the geological evolution is the intrinsic factor of the surface subsidence in the PRD, but human interference (reclamation, ground water extraction and urban construction) extend the subsiding area and accelerate the subsiding rate. This study would provide technique supports for the surface deformation and disaster warning in delta regions.
High Trophinin‑Associated Protein Expression and Its Role in Prognosis of Pancreatic Cancer
Authors: Wang Ruobing , Jiao Yan , Li Yanqing , Wang Yueyuan , Li Yang , Hua Fang , Liu Yahui 
Published: June 2020

Abstract
Background: Trophinin‑associated protein (TROAP) was known as the tastin, which originally recognized as a cytosolic protein involved in embryo implantation. Increasing studies have revealed that high expression of TROAP is related with poor outcomes in cancers. However, there have been few studies on the correlation of TROAP and pancreatic cancer. This study aimed to explore the prognostic significance of TROAP in pancreatic cancer by mining the data collected from The Cancer Genome Atlas (TCGA) dataset. Methods: Clinical information and the RNA expression data were obtained from the TCGA dataset. The correlations between clinical information and TROAP mRNA expression were performed by chi-square and Fisher exact tests. Univariate Cox analyses were used to filter the potential prognostic factors. The correlations between TROAP expression and clinical characteristics of patients with pancreatic cancer were confirmed by multivariate Cox analyses.Results: Analysis of tumor data showed that high expression of TROAP was correlated with poor outcomes in pancreatic cancer patients. Univariate and multivariate Cox analyses demonstrated that TROAP mRNA expression played an important role in shorting overall survival (OS) and relapse-free survival (RFS), which might serve as the useful biomarker and prognostic factor for pancreatic cancer. Conclusions: TROAP was an independent risk factor for pancreatic cancer. TROAP has the potential to be a biomarker, especially in predicting prognosis.
Impact of intratumor heterogeneity on diffusion-weighted MRI as a prognostic indicator in lower rectal cancer
Authors: Kudou Michihiro , Nakanishi Masayoshi , Kuriu Yoshiaki , Arita Tomohiro , Shimizu Hiroki , Kiuchi Jun , Kosuga Toshiyuki , Konishi Hirotaka , Shiozaki Atsush , Kubota Takeshi , Fujiwara Hitoshi , Okamoto Kazuma , Goto Mariko , Yamada Kei , Otsuji Eigo 
Published: June 2020

Abstract
Background

Diffusion-weighed MRI (DWI) has the potential to reveal intra-tumor pathological heterogeneity consisting of the stroma. The present study investigated the value of intra-tumor heterogeneity evaluated by DWI for predicting the survival of patients with lower rectal cancer (LRC).
Methods

A total of 172 LRC patients underwent radical surgery between 2009 and 2017. Patients with T1 tumors, distant metastasis, and no pre-operative MRI were excluded. Fifty-eight cases were targeted. Intra-tumor heterogeneity on DWI was quantified by an image analysis (MRI heterogeneous score of DWI: mrHSD). All enrolled cases were divided into two groups (high and low groups) according to median mrHSD.
Results

Median mrHSD was 0.457 (0.170–0.823), with a higher score indicating a more heterogeneous pattern on DWI. The frequency of a clinical diagnosis of lymph node metastasis and extramural vascular invasion was higher in the high group. Three-year overall survival (OS) and relapse-free survival (RFS) rates were significantly higher in the low group than in the high group (OS: 100% vs 84.6%, p = 0.012; RFS: 85.9% vs 55.6%, p = 0.027). A univariate analysis of RFS showed that the RFS rates of poorly differentiated LRC, a positive circumferential resection margin on MRI, and high mrHSD were worse (p = 0.097, 0.086, and 0.049). A multivariate analysis revealed that high mrHSD tended to be an independent factor for predicting post-operative recurrence (HR: 2.836, p = 0.060).
Conclusion

The quantitative evaluation of intratumor heterogeneity on DWI has potential as an imaging biomarker for predicting post-operative recurrence.
A Feasibility Study of an Intervention for Structured Preparation Before Detoxification in Alcohol Dependence: the SPADe Trial Results
Authors: KOUIMTSIDIS Christos , Houghton Ben , Gage Heather , Notley Caitlin , Maskrey Vivienne , Clark Allan , Holland Richard , Lingford-Hughes Anne Anne , Punukollu Bhaskar Bhaskar , Touray Morro Morro , Duka Theodora 
Published: June 2020

Abstract
BackgroundIndividuals who are ‘moderately’ or ‘severely’ dependent consume alcohol at levels that are likely to have a severe impact on their own health and mortality, the health and behaviours of others (family members), and to have economic and social implications. Treatment guidelines suggest that treatment needs to be planned with medically assisted withdrawal (also referred to as detoxification), and aftercare support. Treatment outcomes are poor with low proportions engaging in after care and high relapse rates. An approach of structured preparation before alcohol detoxification (SPADe) put emphasis on introducing lifestyle changes, development of coping strategies for cravings, stress and emotions as well as introducing changes to the immediate family and social environment in advance of alcohol cessation. Such a pre-habilitation paradigm compliments the established treatment approach. The key research question was: can we design a large scale, randomised controlled trial (RCT) that will answer whether such an approach is more effective than usual care in helping individuals to maintain longer periods of alcohol abstinence?MethodsThis is a pragmatic, parallel, two-arm, feasibility RCT comparing the clinical and cost-effectiveness of SPADe and usual care against usual care only in maintaining alcohol abstinence in adults with alcohol dependence receiving care in two community services in London. The trial follows the guidelines of phase 2 of the Medical Research Council (MRC) for complex interventions. ResultsWe were able to recruit 48/50 participants during a period of 9 months. Retention in the trial was 75%. Treatment compliance was overall 44%. Data completion for the primary outcome was 65%, 50% and 63% at 3, 6 and 12 months respectively. The intervention group had more days abstinent in the previous 90 days at the 12 months (n=54.5) versus control (n=41.5). DiscussionThe results of this feasibility trial indicate that with the appropriate modifications, a full multi centred trial would be possible to test the effectiveness and cost-effectiveness of a pre- habilitation approach such as the SPADe group intervention in addition to usual care against usual care only.Trial RegistrationName of registry: ISRCTN; Trial Registration Number: 14621127; Date of Registration: 22/02/2017; URL of trial registry record: http://www.isrctn.com/ISRCTN14621127
Marker assisted development and characterization of non-GM herbicide tolerant Near Isogenic Lines of a mega Basmati rice variety, “Pusa Basmati 1121”
Authors: Grover Nitasha , Kumar Aruna , Yadav Ashutosh Kumar , S. Gopala Krishnan , Ellur Ranjith Kumar , Bhowmick Prolay Kumar , Vinod K.K. , Bollinedi Haritha , Nagarajan M. , Viswanthan C. , Sevanthi Amitha Mithra V. , Singh Nagendra Kumar , Mohapatra Trilochan , Singh Ashok Kumar 
Published: June 2020

Abstract
Background
Direct-seeded rice (DSR) is a potential technology for sustainable rice farming as it saves water and labor. However, higher incidence of weed under DSR limits productivity. Therefore, there is a need to develop herbicide tolerant (HT) rice varieties.
Results
We used marker assisted backcross breeding (MABB) to transfer a mutant allele of Acetohydroxy acid synthase (AHAS) gene, which confers tolerance to imidazolinone group of herbicides from the donor parent (DP) “Robin” into the genetic background of an elite popular Basmati rice variety Pusa Basmati 1121 (PB 1121). Foreground selection was done using the AHAS gene linked Simple Sequence Repeat (SSR) marker RM6844 and background selection was performed using 112 genome-wide SSR markers polymorphic between PB 1121 and Robin. Phenotypic selection for agronomic, Basmati grain and cooking quality traits in each generation was carried out to improve the recovery of recurrent parent phenome (RPP). Finally, a set of 12 BC4F4 near isogenic lines (NILs), with recurrent parent genome (RPG) recovery ranging from 98.66 to 99.55% were developed and evaluated. PB 1121-HT NILs namely 1979-14-7-33-99-10, 1979-14-7-33-99-15 and 1979-14-7-33-99-66 were found superior to PB 1121 in yield with comparable grain and cooking quality traits and herbicide tolerance similar to Robin.
Conclusion
Overall, the present study reports successful development of non-GM HT NILs in the genetic background of popular Basmati rice variety PB 1121 by introgression of mutated AHAS allele. This is the first report of the development of HT rice in India. Superior NILs are being evaluated in the national Basmati trials, the release of which is likely to provide a viable option for the adoption of DSR technology in Basmati rice cultivation.
Forecasting the Stability of COVID-19 on Indian Dataset with Prophet Logistic Growth Model&nbsp;
Authors: Phutela Nishtha , Bakshi Arushi G , Gupta Sunil , Gabrani Goldie 
Published: June 2020

Abstract
Recently COVID-2019, a highly infectious disease has been declared as Pandemic by WHO, and since then the researchers all over the world are making attempts to predict the likely progression of this pandemic using various mathematical models. In this paper, we are using logistic growth model to find out the stability of this pandemic and Prophet Model to forecast the total number of confirmed cases that would be caused by COVID-19 in India.
Investigating the Role of Environmental Transmission in COVID-19 Dynamics: A Mathematical Model Based Study
Authors: ELmojtaba Ibrahim M. , Al-Musalhi Fatma , Al-Ghassani Asma , Al-Salti Nasser 
Published: June 2020

Abstract
A mathematical model with environmental transmission has been proposed and analyzed to investigate its role in the transmission dynamics of the ongoing COVID-19 outbreak. Two expressions for the basic reproduction number R0 have been analytically derived using the next generation matrix method. The two expressions composed of a combination of two terms related to human to human and environment to human transmissions. The value of R0 has been calculated using estimated parameters corresponding to two datasets. Sensitivity analysis of the reproduction number to the corresponding model parameters has been carried out. Existence and stability analysis of disease free and endemic equilibrium points have been presented in relation with the obtained expressions of R0. Numerical simulations to demonstrate the effect of some model parameters related to environmental transmission on the disease transmission dynamics have been carried out and the results have been demonstrated graphically.
The covid-19 pandemic in Low- and Middle-Income Countries, who carries the burden? Review of mass media and publications from six countries
Authors: Chackalackal Dhia Joseph , Al-Aghbari Ahmed Asa'ad , Jang Su Yeon , Ramirez Tatiana Rivera , Vincent Jose , Joshi Anand , Banjara Megha Raj , Asaga Peter , Sanchez Rocio Cardenas , Carrillo Maria Angelica , Villa Juan Manuel , Monsalve Sonia Diaz , Kroeger Axel 
Published: June 2020

Abstract
Rich countries used in the Covid-19 pandemic lockdown and physical distancing policies for transmission control. However, are these measures also suitable in countries with a fragile economy resting mainly on the informal sector? The impact of lockdown measures in disadvantaged population strata in six Low- and Middle-Income Countries (LMICs) was reviewed using i) systematic review of 17 published papers and ii) review of 90 media reports. Those who most suffered from the lockdown were migrants, workers in the informal sector (which is huge), small businesses, slum dwellers, women and elderly revealing the social, cultural and economic inequalities of societies. Financial and food support for the poor was inadequate and sometimes mismanaged. In the better organized societies, the resilience was stronger (South Korea, Kerala/India) but also here the poor had to suffer most. It is strongly recommended that outbreak response strategies should particularly focus on the poor and vulnerable population.