bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current status of imaging diagnosis in the transplanted kidney. A review of the literature with a special focus on contrast-enhanced ultrasonography
Authors: Badulescu Maria Ramona , Socaciu Mihai Adrian , Moisoiu Tudor , Andries Alexandra , Iacob Gheorghiță , Badea Radu 
Published: March 2020

Objectives. Ultrasonographic scanning is currently the most widespread imaging diagnostic procedure. The method provides real-time morphological, vascular and elastographic information in a non-invasive manner. In recent years, harmonic vascular examination has become accessible using intravenous contrast agents. In urological pathology, this procedure is used in the detection and evaluation of vascular and ischemic complications, in the classification of complex cysts according to the Bosniak system, also in the renal lesions with uncertain etiology and in acute pyelonephritis for the detection of abscesses. The contrast agent (SonoVue) is angiospecific and can be used in patients transplanted immediately after surgery without adverse effects or impaired renal function. Thus, it is desirable to be used in the nephrological pathology of the renal graft and to develop diagnostic models based on the evaluation of renal microvascularization, as well as the quantitative data resulting from the graphical representation of the specific parameters. The purpose of this review is to evaluate the current state of the literature regarding the place and role of contrast substance ultrasound in the early diagnosis of acute renal graft dysfunction and to make a differential diagnosis of this pathological entity.
Method. This review quantifies the role of contrast ultrasound in the diagnosis of acute complications of the renal graft. The research was conducted based on the databases PubMed, MedScape, Cochrane , according to the search criteria such as contrast-enhanced ultrasound + kidney transplant, "time intensity curves" + "kidney transplant”, filtered for the period 2004-2018.
Results. In the nephrological pathology of the renal graft, contrast-enhanced ultrasound is a valuable tool, superior to Doppler ultrasound in predicting the evolution of the renal graft, identifying very small early defects in renal microvascularization. A number of studies succeeded in identifying acute graft dysfunction, some of which establish its etiology - humoral rejection versus acute tubular necrosis. On the other hand, the contrast-enhanced ultrasound parameters do not have the ability to distinguish between cellular and humoral rejection.
Conclusions. If, at present, the histopathological examination is the only one that can differentiate with certainty the cause of acute renal graft dysfunction, we consider that contrast-enhanced ultrasound, as a non-invasive imaging technique, opens a favorable perspective for increasing the survival of the renal graft and decreasing the complications in the renal transplant. The combination of other ultrasound techniques, together with contrast-enhanced ultrasound, could lead to the development of new diagnostic models.
First phytochemical study and biological activity of the leaves ethanolic extract from Cissus spinosa Cambess
Authors: Sinhorin Adilson Paulo , Godoy Bruna Serpa de Almeida , Sinhorin Valéria Dornelles Gindri , Castoldi Lindsey , Sugui Marina Mariko , Bicudo Rogério de Campos 
Published: March 2020

AIMS: The objective of this study was to identify the phytochemical profile and to evaluate the biological effects of the crude ethanolic extract (EE) and the ethanolic fraction (EF) of leaves of the species Cissus spinosa Cambess, after oxidative stress induced by cyclophosphamide (CP) in mice.METHODS: Phytochemical profile was performed detecting functional groups and, analysis of total flavonoids and phenols concentration, as well as the antiradical activity in EE and EF. The phytochemical characterization was done for the identification of flavonoids present in the leaves of the plant. In the biochemical tests, hematological parameters, glucose and total cholesterol dosages in plasma, enzymatic and non-enzymatic antioxidants and lipid damage marker were evaluated in different tissues (liver, kidney and heart), besides genotoxic and immunological analyzes. The animals received 15 days of treatment, via gavage, with EE (50 mg kg-1) or EF (50 mg kg-1) and on the 15th day, an intraperitoneal injection of CP (100 mg kg-1) or saline (0.9%). After 24 h the last treatment, the animals were anesthetized for blood withdrawal, sacrificed and removal of the organs.RESULTS: In the phytochemical analyzes, the presence of alkaloids, flavonoids and phenols was identified, the latter presented a higher concentration for EF. Eight flavonoids were identified - Rutin, Quercetin-3-β-D-glucoside, Quercitrin, Taxifolin, Quercetin, Canferol, Luteolin and Apigenin. In the biochemical analyzes, in general, EE showed a better antioxidant action against oxidative damages, hypoglycemic and antitilipemic action when comparing with EF, probably due to the synergism caused by flavonoids. It was observed the reduction and an increase of micronucleated polychromatic erythrocytes, due to the action of antioxidant compounds and alkaloids present in the plant, also considering the question of the seasonal period that directly interferes in the production of these compounds. In the immunological analysis, the extracts did not stimulate the spontaneous production of oxygen peroxide (H2O2) and nitric oxide (NO•). CONCLUSIONS: Other studies, such as the variation of the chemical composition of the plant by local seasonality, hypoglycemic and antilipemic action, should be carried out to better delineate the biological action present in this plant.
A comparison of reactivation experiences following vaporization and intramuscular injection (IM) of synthetic 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting
Authors: Uthaug Malin V. , Lancelotta R. , Ortiz Bernal A. M. , Davis A. K. , Ramaekers Johannes G. 
Published: March 2020

AbstractBackgroundPrevious research suggests a therapeutic potential of5-methoxy-N,N-dimethyltryptamine(5-MeO-DMT). However, online anecdotal reports have described a phenomenon following cessation of the acute effects of 5-MeO-DMT use which has been termedreactivation(i.e., re-experiencing [“flashback”]). To date, no research has investigated whether different routes of administration may confer different reactivation rates, effects and experiences.AimsWe aimed to assess whether intramuscular injection (IM) and vaporization of 5-MeO-DMT conferred different reactivation rates, changes in satisfaction with life as well as ratings of the experience with ego dissolution and the mystical.MethodsUsing internet-based advertisements, 27 respondents (Mage= 32. SE = 1.43; males = 18; North America = 19) completed an online-based survey.ResultsOf the 14 participants in the IM group, 3 (21%) reported reactivations; in contrast, of the 13 participants in the vaporization group, 9 (69%) reported reactivations. Redosing (more than 1 dose) occurred more frequently in the vaporization group (N= 8) (1–6 times with 3–35 mg of 5-MeO-DMT), relative to the IM group (N= 2) (1–5 times with 5–10 mg of 5-MeO-DMT). All participants in the IM group experienced release of physical tension, compared to 8 participants in the vaporization group. Participants in the IM group reported longer time of onset of acute effects (between 1 and 3 [N= 6] and 4–6 min [N= 6]), relative to the vaporization group where the majority (N= 11) reported a rapid onset of 1–50 s.ConclusionFindings suggest that compared to vaporization, the IM route of administering 5-MeO-DMT is associated with lower and less doses, lower frequencies of reporting reactivation, a higher frequency of physical tension release, and a slower onset of acute effects.
Free vibration of FG sandwich plates partially supported by elastic foundation using a quasi-3D finite element formulation
Authors: Ich Le Cong , Nam Pham Vu , Kien Nguyen Dinh 
Published: March 2020

Free vibration of functionally graded (FG) sandwich plates partially supported by a Pasternak elastic foundation is studied. The plates consist of three layers, namely a pure ceramic hardcore and two functionally graded skin layers. The effective material properties of the skin layers are considered to vary in the plate thickness by a power gradation law, and they are estimated by Mori--Tanaka scheme. The quasi-3D shear deformation theory, which takes the thickness stretching effect into account, is adopted to formulate a finite element formulation for computing vibration characteristics. The accuracy of the derived formulation is confirmed through a comparison study. The numerical result reveals that the foundation supporting area plays an important role on the vibration behavior of the plates, and the effect of the layer thickness ratio on the frequencies is governed by the supporting area. A parametric study is carried out to highlight the effects of material distribution, layer thickness ratio, foundation stiffness and area of the foundation support on the frequencies and mode shapes of the plates. The influence of the side-to-thickness ratio on the frequencies of the plates is also examined and discussed.
Research Program: Modeling of Motor Abilities Development and Teaching of Schoolchildren
Authors: Ivashchenko Olha 
Published: March 2020

The purpose of this study was to find methodological approaches to the development of a research program in modeling the process of teaching physical exercises, motor abilities development and pedagogical control in schoolchildren’s physical education.
Materials and methods. The total number of schoolchildren involved in the experiment was: 6-10 years old – 465 (240 boys and 225 girls); 11-13 years old – 430 schoolchildren (205 boys and 225 girls); 14-16 years old – 221 schoolchildren (122 boys and 99 girls). To achieve the purpose set, the following research methods were used: modeling, systems approach, methods of theoretical analysis and generalization; pedagogical testing, methods of recording the respiratory system state, observation and pedagogical experiment; methods of mathematical analysis (logistic and asymptotic functions); mathematical methods of planning multifactorial experiments. Factor, discriminant, and regression analyses were performed.
Results. The research program of modeling schoolchildren’s physical education includes the development of factor, discriminant, and regression models to obtain new information for planning and managing the processes of teaching physical exercises, motor abilities development, and pedagogical control in schoolchildren’s physical education.
Conclusions. Modeling is an effective tool for studying the regularities of motor training and for developing physical education programs for children and adolescents. In the program of modeling schoolchildren’s physical education, initial data, study object, research methods must meet the following conditions: parametrical description (formulation of tasks, consideration of physical components, analysis of coefficients); initial data (information potential, reliability, accuracy, quantity); methods (similarity, accuracy, implementation time, coincidence with control criteria).
Motor Skills Development: Optimization of Teaching Boys Aged 15 Press Headstand and Handstand
Authors: Khudolii Oleg , Kapkan Olena , Harkusha Sergii , Marchenko Svitlana , Veremeenko Viktoriia 
Published: March 2020

The study objective was to substantiate the modes of alternation of physical exercises and rest intervals when teaching series of tasks aimed at motor skills development in boys aged 15 years.
Materials and methods. The participants in the study were 40 boys aged 15. The children and their parents were fully informed about all the features of the study and gave their consent to participate in the experiment. To achieve the objective set, the following research methods were used: study and analysis of scientific and methodological literature; pedagogical observation, timing of training tasks; pedagogical experiment, methods of mathematical statistics, methods of mathematical experiment planning. During training, the method of algorithmic instructions was used.
Results. The study found that the effectiveness of mastering series of training tasks depends on a mode of alternation of exercises and rest intervals. The results of analysis of variance and regression models show that the optimal mode of performing series of training tasks is within the range of 6-12 exercise repetitions with rest intervals of 60-120 sesonds. In the proposed matrix of factorial design, the selected step of factor variation is sufficient to study the impact of different modes of physical exercises on the effectiveness of teaching children and adolescents.
Conclusions. The best options for teaching series of tasks to boys aged 15 during physical education classes are the following: series 1 – 12 repetitions, rest interval of 60–120 s; series 2 – 12 repetitions, rest interval of 120 s; series 3 – 12 repetitions, rest interval of 120 s; series 4 – 12 repetitions, rest interval of 120 s; series 5 – 12 repetitions, rest interval of 60 s; series 6 – 12 repetitions, rest interval of 60 s.
Peculiarities of Motor Fitness Dynamics of 5th-6th Grade Students During a School Year
Authors: Tkachenko Mykyta 
Published: March 2020

The study purpose was to determine the impact of physical education classes on the dynamics of motor fitness of 5th-6th grade students.
Materials and methods. The study participants were 17 5th grade boys and 17 6th grade boys. The study used the following methods: analysis of scientific and methodological literature, pedagogical testing and methods of mathematical statistics for processing the study results. Thematic planning of educational work was carried out based on the updated physical education curriculum for 5th-9th grades of general educational institutions.
Results. There are statistically significant changes in the 5th grade boys’ results of educational standards: Test 2 “Shuttle run 4×9 m (sec)” and Test 4 “Standing long jump (cm)” (p < 0.05). The results in Test 2 improve by 6.2 %, in Test 4 by 7.1 %. There are statistically significant changes in the 6th grade boys’ results of educational standards: Test 2 “Shuttle run 4×9 m (sec)” (p < 0.1) and Test 4 “Standing long jump (cm)” (p < 0.05). The results in Test 2 improve by 4.4 %, in Test 4 by 12.9 %.
Conclusions. Discriminant analysis revealed that by the multivariate mean the boys’ motor fitness at the beginning and end of the school year is classified as two different states. This indicates a positive impact of physical education classes on the dynamics of motor fitness of 5th and 6th grade boys.The level of schoolchildren’s motor fitness depends on coordination and speed-strength training carried out during physical education classes.
El treball cooperatiu
Authors: Oller Freixa Montserrat 
Published: March 2020

Ressenya del llibre: Gavaldà, Antoni (coord.), Josep M. Pons-Altés, Víctor Grau, Joan Callarisa, Jacint Torrents (2016) El treball cooperatiu. Una estratègia per ensenyar des de les ciències socials, Tarragona: Publicacions URV i Publicacions de la UVic-Eumogràfic.
Spatiotemporal Seismotectonic Implications for the Izu–Bonin–Mariana Subduction Zone from b-Values
Authors: Gui Zhou , Bai Yongliang , Wang Zhenjie , Dong Dongdong , Wu Shiguo , Li Tongfei 
Published: March 2020

AbstractStudies on the physical properties of the entire Izu–Bonin–Mariana (IBM) subduction zone contribute to comprehensive seismotectonic understanding and earthquake potential assessment, especially given previous controversial conclusions. Determining seismic b-value is a method that has been used for other regions and is adopted here to study the spatiotemporal variations along the IBM system. Based on the frequency–magnitude distribution relation log10(N)=a−bM, b-values are mapped within the subduction zone using earthquakes with Mw≥2 after 2005. The b-value anomalies in cross sections indicate detailed seismotectonic characteristics against the regional geological background. The common characteristics from north to south: (1) regional high b-values at shallow depths in the overriding are associated with relatively low temperatures in thermal model, the bottom half of which correspond with highly serpentinized mantle wedge; and (2) low b-values at intermediate depths are associated with high temperatures along the primarily heated hydrated slab. In the Izu–Bonin segment, low b-values around the slab deflection at deep depths respond to stress buildup and shearing instability of metastable olivine in primarily heated hydrated slabs. In the Mariana segment, high b-values beneath the volcanic region at depths from the surface to 50 km and between 50 and 100 km are associated with extension and volcanism and the melting region, respectively. Temporal b-value variations indicate regional changes before and after large events for further seismic risk analysis. Stress drops of large intermediate and deep earthquakes are negligible to local stress state in strong flexure of the incoming slab. The rupture zone around the Pagan region at an approximate depth of 200 km and the region around the rifting–spreading transition in the northern Mariana trough at depths between 180 and 350 km are areas for potential large earthquakes.
Exploring the Antecedents of Safety Performance for Malaysian Construction Industry: A Conceptual Framework
Authors: Chowdhury Mohammad Fazley Hossain , Ahmad Rusli bin 
Published: March 2020

This conceptual paper intends to present as a proposition of a framework to understand the antecedents of safety performance behaviors. The elements of performance which refer to the tangible behaviors exhibited by individuals at work, safety participation and safety compliance, are crucial in maintaining safe workplace for construction industry. This article illustrates potential antecedents in determining safety performance behaviors as effect of safety leadership attributes and safety climate components based on the Wu et al. (2008) model and current literature in this field. The article contributes to a better understanding of safety situation in the construction industry through the relationships among safety leadership behaviors, safety climate components and safety performance behaviors. This paper ends with a suggestion of the conceptual framework to study the antecedents of safety performance in the context of Malaysian construction industries.
An Analysis of Trade Specialization in Bangladesh, 1996-2011
Authors: Sikdar Md. Mehedi Hasan 
Published: March 2020

Trade specialization has been studied extensively, and many researchers try to explain the patterns of the specialization and different factors that determine it. By using the Revealed Symmetric Comparative Advantage Index and the Galtonian Regression Technique, this study tries to determine the industries with trade specialization and analyze the transformation of the pattern of trade specialization in Bangladesh in the period 1996-2011 to show how the export and import specialization of industries changed and to what extent the pattern of trade specialization in Bangladesh has been transformed during the last sixteen years. Empirical analysis showed that the export of Bangladesh consists mainly of the garment industry, and Bangladesh import products largely belong to the category of commodities for further production and the support of the exporting sector. From the Galtonian regression analysis of export and import specialization, it has been found that the level of export diversification is very low, relatively stable which is confirmed by the low mobility effect. Bangladesh’s export specialization pattern is highly concentrated only in apparel products over the whole study period, and all other sectors contribute with a significantly smaller amount in total export share, but import is more diversified. For the development of the country, it is necessary to diversify its export basket.
Institutional Leadership or Institutional Overreach?
Authors: Chong Daniel LING Tien 
Published: March 2020

The institutions of international arbitration have played an increasingly active role in arbitral governance. The claim that they merely provide administrative services no longer holds water. With the ability to amend institutional rules, update practice guidelines, and revise institutional practices, they wield the power to efficiently effect change – a power that no other actor in international arbitration comes close to having.
However, it has been said that in their quest to lead change, some institutions have overstepped their mandate and overreached their powers. Based on a variety of primary and secondary sources, this article examines the situations in which institutions have overridden the parties’ agreement for the number of arbitrators appointed in cases of expedited proceedings. Thereafter, it seeks to analyze whether institutions, in a bid to push progress have overstepped their authority.
A retrospective study of adverse drug reactions in a tertiary care center
Authors: L. Ankitha , H. Ramesh 
Published: March 2020

Background: Adverse drug reactions (ADRs) are a major concern in clinical practice. Reporting of ADRs either through health care professionals or the patients themselves is of utmost importance to give an accurate estimate of the prevalence, severity and preventability of ADRs. Present study was conducted to evaluate the prevalence of adverse drug reactions in a tertiary care hospital in Hubballi, Karnataka, India.Methods: This was a retrospective observational study, extending over 6 months (May 2019 to October 2019). A total of 124 cases comprising patients of either sex and age group ranging from 1month to 72 years were studied. The data was collected using CDSCO ADR reporting form. “Naranjo’s Assessment Scale” was used for causality assessment and severity assessment was done in accordance with “Hartwig and Siegel scale”.Results: The study showed majority of ADRs were from General Medicine department and affected skin and appendages (59%). Skin rashes 44 (31.7%) were found to be the most commonly reported ADRs most of them were with antimicrobials 67 (54%). After causality assessment 83 (66.9%) of the cases were classified as probable and 41 (33.1%) were classified as possible. Majority of serious ADRs were not preventable in our study.Conclusions: ADRs are a major cause of morbidity worldwide. Frequency of ADRs can be reduced by careful follow up and a robust hospital-based pharmacovigilance setup. Measures to improve detection and reporting of adverse drug reactions by all health care professionals is recommended.