bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Influence of Powered Prostheses on User Perspectives, Metabolics and Activity: A Randomized Crossover Trial
Authors: Kim Jay , Wensman Jeffrey , Colabianchi Natalie , Gates Deanna 
Published: November 2020

Abstract
Background: Powered prosthetic ankles provide battery-powered mechanical push-off, with the aim of reducing the metabolic demands of walking for people with transtibial amputations. The efficacy of powered ankles has been shown in active, high functioning individuals with transtibial amputation, but is less clear in other populations. Additionally, it is unclear how powered prosthetic use influences everyday physical activity and mobility.Methods: Individuals with unilateral transtibial amputations participated in a randomized clinical trial comparing their prescribed, unpowered prosthesis and the BiOM powered prosthesis. Participants’ metabolic costs and self-selected walking speeds were measured in the laboratory and daily step count, daily steps away from home, and walking speed were measured over two weeks of at-home prosthetic use. Participants also rated their perception of mobility and quality of life and provided free-form feedback. Dependent measures were compared between prostheses and the relationships between metabolic cost, perception of mobility, and characteristics of walking in daily life were explored using Pearson’s correlations.Results: Twelve people were randomly allocated to the powered prosthesis first (n = 7) or unpowered prosthesis first (n = 5) and ten completed the full study. There were no differences in metabolic costs (p = 0.585), daily step count (p = 0.995), walking speed (p ≥ 0.145), or perception of mobility between prostheses (p ≥ 0.058). Changes varied across participants, however. There were several medium- and large-sized effects for device comparisons. With the powered prosthesis, participants had decreased walking speeds in daily life (g = 0.310), increased self-reported ambulation (g = 0.682), and decreased frustration (g = 0.506). Greater preference for the powered prosthesis was moderately correlated with increased everyday walking speed (r = 0.636, p = 0.090).Conclusions: There were no universal benefits of the powered prosthesis on function in the lab or home environment. However, the effects were subject-specific, with some reporting preference for power and improved mobility, and some increasing their activity and decreasing their metabolic effort. Additionally, self-reported preferences did not often correlate with objective measures of function. This highlights the need for future clinical research to include both perception and objective measures to better inform prosthetic prescription.Trial registration: https://clinicaltrials.gov, #NCT02828982. Registered 12 July 2016, https://clinicaltrials.gov/ct2/show/NCT02828982
MicroRNA-450a/PPM1L Axis Contributes to The Malignant Phenotype of Glioma
Authors: You Jian , Chen Xiufen , Zhou Jie , Peng Lilei , Ming Yang , Liu Liang , Xu Ruxiang , Chen Ligang 
Published: November 2020

Abstract
MicroRNAs play an important role in glioma, and the function of miR-450a in glioma is unknown. We aimed to clarify the role and underlying mechanism of miR-450a in glioma. We analyzed the miR-450a expression and prognosis data of glioma patients from TCGA and CGGA databases. CCK8, colony formation, nude tumor formation, transwell and wound healing assay investigated glioma cells transfected with miR-450a inhibitor growth, invasion and migration, respectively. Bioinformatics and luciferase reporter assay were applied to predict and verify the direct target gene of miR-450a. In this study, we found that miR-450a expression was significantly higher in glioma tissues and cells than the normal tissues and cells, and there is a positive correlation between miR-450a expression and histopathological grade of gliomas. In addition, the glioma patients with high miR-450a expression exhibited poorer prognosis. Downregulation of miR-450a remarkedly suppressed glioma cells growth in vitro and vivo, and inhibited glioma cells invasion and migration. Luciferase reporter assay verified that PPMIL is a direct target of miR-450a. PPM1L silencing partially rescued miR-450a knockdown-induced suppressive effects on glioma cells. Therefore, our data demonstrated that miR-450a/PPM1L axis could mediate the malignant phenotype of glioma, which provided a feasible target for glioma therapy.
Molecular Data Reveals Rich Diversity of the Sequestrate Genus Melanogaster (Boletales, Paxillaceae) with Emphasis on the Species from China
Authors: Yan Xiang-yuan , Xu Yu-yan , Li Ting , Zhao Tao-yu , Lv Jing-chong , Fan Li 
Published: November 2020

Abstract
Malanogaster are ectomycorrhizal fungi characterized by hypogeous fruitbodies. Many ITS rDNA sequences of Malanogaster are recovered from molecular surveys of fungal communities, and remain insufficiently identified making it difficult to determine whether these sequences represent conspecific or novel taxa. In this study, the ITS sequences of Malanogaster were collected comprehensively and analyzed within ITS-based phylogenetic framework. Twenty-one distinct phylogenetic species can be distinguished based on the ITS phylogeny and a threshold of 98% ITS sequence identity, and most species of Melanogaster showed more than 98.1% intraspecific ITS identity and less than 97.9% interspecific identity. Ten species were recognized from China, but combined morphology, nine of which were described and illustrated in this manuscript, including 4 new species (M. minobovatus nov. sp., M. panzhihuaensis nov. sp., M. quercus nov. sp. and M. tomentellus nov. sp.), 1 new combination (M. obvatus comb. & stat. nov.), and 4 known species (M. broomeanus, M. shanxiensis, M. spinisporus, M. subglobisporus). Significantly amendments were added to M. spinisporus and M. subglobisporus. M. fusisporus was added a new mature specimen from type location, and the description and exquisite illustrations were provided also. The diagnostic characteristics of the genus Melanogaster and a key to the Chinese species of the genus Melanogaster were provided. A 28 Sphylogeny was also conducted to confirm the phylogenetic locations of Chinese Melanogaster species and “Alpova trappei”, consistented with ITS analysis.
No Coil® Placement in Patients Undergoing Left Hemicolectomy and Low Anterior Resection for Colorectal Cancer
Authors: Ammendola Michele , Ruggiero Michele , Talarico Carlo , Memeo Riccardo , Ammerata Giorgio , Capomolla Antonella , Filippo Rosalinda , Romano Roberto , Pallio Socrate , Navarra Giuseppe , Montemurro Severino , Currò Giuseppe 
Published: November 2020

Abstract
Background. Colorectal cancer (CRC) is the most common tumor of the gastrointestinal tract. Anastomotic leak (AL) and prolonged post-operative ileus (PPOI) are two important complications of colorectal surgery. In this observational retrospective study, we evaluated the positive effects of transanal tube No Coil® in patients with CRC undergoing low anterior resection (LAR) and left hemicolectomy (LC).Methods. Thirty-eight cases and forty controls resulted eligible for the final sample. No Coil® placement (SapiMed Spa, Alessandria, Italy) was considered an inclusion criteria for the case group No Coil® was placed immediately after the end of surgical treatment.Results. PPOI was significantly more frequent in the control group. AL was evident in 1 patient (2.6%) of cases and 3 patients of control group (7.5%). No statistical difference was found in AL occurrence between groups. POI days and AL resulted associated with hospital stay. POI days were negatively associated with No Coil placement, and positively with AL.Conclusion. With our preliminary data, we suggest that No Coil® placement can be considered as a valuable procedure assisting colorectal surgery, but further studies are required to confirm and enlarge actual evidence.
WITHDRAWN: Defining and Characterizing Task-Shifting Medical Device
Authors: Sarvestani Amir Sabet , Coulentianos Marianna Joy , Sienko Kathleen H 
Published: November 2020

Abstract
Background Task shifting could help address limited human resources available for the delivery of quality health care services in low-resource settings. However, the role of medical devices in supporting task shifting is not fully understood. This study aimed to 1) define “task-shifting medical devices” and 2) identify product characteristics to guide the design and development of task-shifting medical devices.A three-part survey questionnaire comprising open-ended, rank-ordering, and multiple-choice questions was disseminated to healthcare professionals worldwide. The survey included questions to capture stakeholders’ general understanding of and preferences for task shifting in medicine and public health, and questions to define task-shifting medical devices and identify desirable product characteristics. Results Task-shifting medical devices were defined by respondents as “devices that can be used by a less specialized health worker”. Aside from safe and effective, both essential characteristics for medical devices, easy to use was the most cited product characteristic for a task-shifting medical device. Respondents further defined “easy to use” task-shifting medical devices as simple devices that leverage digital or automated features and are supportive of data management and privacy protection good practices. Responses also emphasized the importance of task-shifting medical devices to enable local agency, such as peer-to-peer training and local maintenance. Several additional frequently mentioned attributes included low cost, contextually appropriate, maintainable, capable of using an alternative power source, easy to understand, easy to learn, reusable, and easy to manage throughout its use cycle. Conclusion This study defines and characterizes task-shifting medical devices based on healthcare professionals’ responses. Ease of use was identified as the most important characteristic that defines a task shifting medical device, in addition to safe and effective, and was strongly associated with enabling peer-to-peer training and maintainability. The findings from this study can be used to inform technology product profiles for medical devices used by lower-level cadres of healthcare workers in low-resource settings.
Forecast of Football League Sales Effect Based on BP Neural Network
Authors: Xu Zhubo , Qin Weifeng 
Published: November 2020

Abstract
Football is one of the sports that is loved by people all over the world. Its sales ability in the league should not be underestimated. Moreover, football has been developed in our country since ancient times and has a huge fan base, and fans are the main target of football league sales. Predicting the sales effect of the football league is helpful for the seller to formulate a suitable sales strategy and avoid the problem of product surplus. This article mainly introduces the prediction research of football league sales effect based on BP neural network, and intends to provide ideas and methods for predicting the sales effect of football league. This paper puts forward the basic method of the sales effect prediction of the football league and the BP neural network football league sales effect prediction method to analyze and predict the sales effect of the football league. In addition, the steps of establishing BP neural network design, building BP neural network football league sales effect prediction model and applying BP neural network football league sales effect prediction model are also proposed. The experimental results of this article show that the difference between the fitting part of the neural network model and the real value of the football league sales effect sample data is in the range of , the error percentage difference is small, and the prediction results are valid。
Unilateral Percutaneous Vertebroplasty For Osteoporotic Lumbar Compression Fractures: A Comparative Study Between Transverse Process Root-Pedicle Approach And Conventional Transpedicular Approach
Authors: Zhang Wenwu , Liu Shenpeng , Liu Xianhua , Li Xiang , Wang Le , Wan Yong 
Published: November 2020

Abstract
Purpose: Percutaneous Vertebroplasty (PVP) is a routine operation for the treatment of osteoporotic lumbar compression fracture (OLCF). Because of bilateral puncture takes a long operation time and patients receive more X-ray irradiation, more and more scholars deem that the unilateral approach should be adopted. But, with conventional transpedicular approach (CTPA), the cement may asymmetrically dispersed, so some surgeons use the transverse process root-pedicle approach (TPRPA). The objective of this study is to compare the clinical results and bone cement distribution of PVP for OLCF with unilateral TPRPA and CTPA, determine the advantages and disadvantages of the two surgical options.Patients and methods: From January 2016 to June 2019, seventy-two elderly patients who underwent unilateral PVP for single-level OLCF were retrospectively reviewed. Operation time, injection amount and distribution type of bone cement, and bone cement leakage and surgical complication were recorded. The visual analogue scale (VAS) scores and Oswestry disability index (ODI) scores were used to evaluate the clinical results. All patients were followed up for at more than 12 months and the assessment was based primarily on clinical and radiological outcomes.Results: There were significant difference in the surgical time, the volume and distribution type of bone cement between the two groups. But, there was no statistical difference in bone cement leakage. Moreover, there were no significant differences in VAS and ODI between the two groups at 2 days and 12 months after operation.Conclusion: Unilateral TPRPA and CTPA are practical and feasible methods in PVP for treatment of OLCF, with similar clinical effects. However, TPRPA has the advantages of fair distribution of bone cement and short operation time, without increasing the rate of bone cement leakage.
Teleradiology as a relevant indicator of the impact of COVID-19 pandemic management on Emergency Room activities: a nationwide worrisome survey
Authors: Vatele Jordan , Gentile Stephanie , THOMSON Vivien , DEVICTOR Bénédicte , CLOUX Marine , GIROUIN Nicolas , BRATAN Flavie , BERGEROT Jean-François , SEUX Mylène , BANASTE Nathan , TAZAROURTE Karim , GORINCOUR Guillaume 
Published: November 2020

Abstract
Objectives: To evaluate the impact of COVID-19’s lockdown on radiological examinations in Emergency Services.Methods: Retrospective, multicentre analysis of radiological examinations requested, via our teleradiology network, from 2017 to 2020 during two timeframes (calendar weeks 5 to 8 and then 12 to 15).We included CT-scans or MRIs performed for strokes, multiple traumas (body-CT, BC), cranial traumas (CTr) and acute non-traumatic abdominal pain (ANTAP). We evaluated the number and percentages of examinations performed, of those with a pathological conclusion, and of examinations involving the chest.Results: Our study included 25 centres in 2017, 29 in 2018, 43 in 2019 and 59 in 2020.From 2017 to 2019, the percentages of examinations were constant, which was also true for chest CTs. Each centre’s number of examinations, gender distribution and patient ages were unchanged.In 2020, examinations significantly decreased : suspected strokes decreased by 36% (1052 vs 675, p <0.001), BC by 62% (349 vs 134, p <0.001), CTr by 52% (1853 vs 895, p <0.001) and for ANTAP, appendicitis decreased by 38% (145 vs 90, NS) sigmoiditis by 44% (98 vs 55, NS), and renal colic by 23% (376 vs 288, NS).The number of exams per centre decreased by 13% (185.5 vs. 162.5, p <0.001) whereas the number of examinations of the "chest" region increased by 170% (1205 vs 3766, p <0.001).Conclusion: Teleradiology enabled us to monitor the impact of the COVID-19 pandemic management on emergency activities, showing a global decrease in the population's use of care
Clinical characteristics and risk factors for mortality in patients with COVID-19 and chronic obstructive pulmonary disease in Wuhan, China
Authors: Zeng Hao , Huang Weiwei , Liu Yujie , Dong Lan , Zhang Qifan , Zhao Shengmin , Xin Luowen , Huang Zhixin , Li Yalun , Tian Panwen 
Published: November 2020

Abstract
Patients with COVID-19 and COPD are at high risks. However, the risk factors for mortality in COPD patients infected COVID-19 are limited. In this retrospective study, consecutive COPD cases infected COVID-19 in East District of People's Hospital of Wuhan University from Jan 11th 2020 to Mar 28th 2020 were included. Different outcomes were compared between dead and discharged patients. Cox regression analysis was performed to explore the risk factors for death. Totally, 52 cases were included (aged 64.0-79.0 years, 39 [75.0%] males). Common symptoms on admission were cough (43, 82.6%), fever (41, 78.8%) and expectoration (21, 40.3%). Thirty-eight (73.1%) patients were discharged, and 14 (26.9%) cases were dead which mainly caused by multiple organ failure (7, 50.0%) and respiratory failure (6, 42.9%). Multivariate analysis indicated that age > 70 years (HR, 7.859, 95% CI: 1.376, 44.875; P = 0.020) and count of lymphocyte ≤ 0.8×109/L (HR, 27.429, 95% CI: 3.336, 225.530; P = 0.002) were risk factors for death. The study showed that close monitoring of the risk indexes is important for early supportive care during the management of patients with COVID-19 and COPD.
Income differences in screening, incidence, postoperative complications, and mortality of thyroid cancer in South Korea: a national population-based time trend study
Authors: Kang Hee-Yeon , Kim Ikhan , Kim Yeon-Yong , Bahk Jinwook , Khang Young-Ho 
Published: November 2020

Abstract
Background: The incidence of thyroid cancer (TC) has increased rapidly over the past few decades in Korea. This study investigated whether the TC epidemic has been driven by overdiagnosis. Methods: We calculated the TC screening rate from mid-2008 through mid-2014, and the incidence, postoperative complication, and mortality rates of TC between 2006 and 2015, using data from the Korea Community Health Survey, the National Health Insurance Database, and the cause-of-death data of Statistics Korea. Trends in age-standardized rates of all indicators were examined, along with income gaps therein. Analyses were conducted for lung cancer and stroke as negative control outcomes. Results: The incidence rate of TC increased from 46.6 per 100,000 to 115.0 per 100,000 between 2006 and 2012, and then decreased to 63.5 per 100,000 in 2015. Despite these remarkable changes in incidence, mortality did not fluctuate during the same period. High income was associated with high rates of screening, incidence, and postoperative complications, while low income showed an association with a high mortality rate. Analyses using negative control outcomes showed that high income was associated with low rates of both incidence and mortality, which contrasted with the patterns of TC. The recent decreases in TC incidence and postoperative complications, which reflect societal concerns about the overdiagnosis of TC, were more pronounced in high-income individuals than in low-income individuals. Conclusions: The time trends in income gaps in screening, incidence, postoperative complications, and mortality of TC, as well as negative control outcomes, provided corroborating evidence of TC overdiagnosis in Korea.
Moral neutralization: Nurses' evolution in unethical climate workplaces
Authors: Hakimi Hamideh , Joolaee Soodabeh , Farahani Mansoureh Ashghali , Rodney Patricia , Ranjbar Hadi 
Published: November 2020

Abstract
Introduction: Good quality of care is dependent on nurses’ strong clinical skills and moral competencies, as well. While most nurses work with high moral standards, the moral performance of some nurses in some organizations shows a deterioration in their moral sensitivity and actions. The study reported in this paper aimed to explore the experiences of nurses regarding negative changes in their moral practice.Materials and Methods: This was a qualitative study utilizing an inductive thematic analysis approach, which was conducted from February 2017 to September 2019. Twenty-five nurses participated in semi-structured interviews. Results: The main theme that emerged from our analysis was one of moral neutralization in the context of an unethical moral climate. We found five sub-themes, including: (1) feeling discouraged; (2) normalization; (3) giving up; (4) becoming a justifier; and (5) moral indifference.Conclusions: Unethical moral climates in health organizations can result in deterioration of morality in nurses which can harm both patients and health systems. Some unethical behaviors in nurses can be explained by this process.
Big data analysis of Pulmonary Embolism in Greece
Authors: Lampropoulos Ioannis Ch , Raptis Dimitrios G , Daniil Zoe , Tasoulis Sotirios K , Plagianakos Vassilis P , Malli Foteini , Gourgoulianis Konstantinos I 
Published: November 2020

Abstract
Background: Pulmonary embolism (PE) epidemiological data are unclear considering the disease prevalence in the general population. The present study aims to investigate the prevalence of PE at the Greek population and the associated trends for the years 2013-2017. Methods: Data on medical prescriptions for PE in the years 2013-2017 were provided by the Greek National Health Service Organization (EOPYY). Data on age, gender, specialty of the prescribing physician and prescription unit were provided as well. Results: The total number of medical prescriptions for PE for the study period was 101,426. Of the total prescriptions, 51% were issued by the Public Sector, while 48% by the Private Sector. In 2013 the prevalence of PE was 5.43 cases per 100,000 citizens and increased constantly until 2017 with 23.79 cases per 100,000 population. Prevalence is higher in all years studied in the age group 70-80 with 69.35 cases per 100,000 population for the year 2017 followed by the ages 80-90 (60.58/100,000) and 60-70 (56.47/100,000) for the same year. Females display higher PE prevalence than males and higher increasing trend.Conclusion: PE prevalence displays an increasing trend throughout the years while prevalence in females is higher than males and displays a higher increasing trend. Our results may be used to appropriately organize nationwide health care systems aiming at the diagnosis, treatment and prevention of PE.