bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supplementation of lamb diets with vitamin E and rosemary extracts on meat quality parameters
Authors: Leal Leonel N , Beltrán José A , Marc Bellés  , Bello José M , den Hartog Leo A , Hendriks Wouter H , Martín‐Tereso Javier 
Published: February 2020

AbstractBACKGROUNDSupranutritional supplementation of lamb diets with α‐tocopherol is an effective method to reduce lipid oxidation and colour deterioration in meat products. However, alternative antioxidant sources have been proposed to replace the supranutritional vitamin E applications.RESULTSIndoor concentrate‐fed Rasa Aragonesa male lambs (n = 480) were supplemented with increasing levels of all‐rac‐α‐tocopheryl acetate (0.25, 0.5, 1.0 g kg−1 compound feed), rosemary extract (0.20, 0.40, or 0.80 g kg−1 compound feed), or rosemary extract embedded in a fat matrix (0.20, 0.40, or 0.80 g kg−1 compound feed) for 14 days before slaughter. The longissimus thoracis et lumborum muscle from three lambs per pen (18 lambs per treatment) were modified‐atmosphere packaged (70% O2 + 30% CO2) and maintained under retail conditions for 14 days. Supranutritional supplementation with antioxidants had no effect (P > 0.05) on average daily weight gain, feed intake, and feed efficiency. Rosemary extract supplementation (with or without fat embedment) had no effect on lipid oxidation, myoglobin forms, or colour stability parameters, regardless of the dose. All vitamin E supplementation levels significantly affected lipid oxidation, colour stability (L*, C*, and h), myoglobin forms, and meat discoloration parameters compared with non‐supplemented lambs.CONCLUSIONSThis study demonstrates that, unlike vitamin E, neither dose nor protection of the rosemary extract had an effect on lipid oxidation or meat colour stability of lambs during the 14 days of storage under retail conditions. © 2020 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Modifier genes in SCN1A‐related epilepsy syndromes
Authors: de Lange Iris M. , Mulder Flip , van 't Slot Ruben , Sonsma Anja C. M. , van Kempen Marjan J. A. , Nijman Isaac J. , Ernst Robert F. , Knoers Nine V. A. M. , Brilstra Eva H. , Koeleman Bobby P. C. 
Published: February 2020

AbstractBackgroundSCN1A is one of the most important epilepsy‐related genes, with pathogenic variants leading to a range of phenotypes with varying disease severity. Different modifying factors have been hypothesized to influence SCN1A‐related phenotypes. We investigate the presence of rare and more common variants in epilepsy‐related genes as potential modifiers of SCN1A‐related disease severity.Methods87 patients with SCN1A‐related epilepsy were investigated. Whole‐exome sequencing was performed by the Beijing Genomics Institute (BGI). Functional variants in 422 genes associated with epilepsy and/or neuronal excitability were investigated. Differences in proportions of variants between the epilepsy genes and four control gene sets were calculated, and compared to the proportions of variants in the same genes in the ExAC database.ResultsStatistically significant excesses of variants in epilepsy genes were observed in the complete cohort and in the combined group of mildly and severely affected patients, particularly for variants with minor allele frequencies of <0.05. Patients with extreme phenotypes showed much greater excesses of epilepsy gene variants than patients with intermediate phenotypes.ConclusionOur results indicate that relatively common variants in epilepsy genes, which would not necessarily be classified as pathogenic, may play a large role in modulating SCN1A phenotypes. They may modify the phenotypes of both severely and mildly affected patients. Our results may be a first step toward meaningful testing of modifier gene variants in regular diagnostics for individual patients, to provide a better estimation of disease severity for newly diagnosed patients.
A cavity expansion–based solution for interpretation of CPTu data in soils under partially drained conditions
Authors: Mo Pin‐Qiang , Gao Xin‐Wei , Yang Wenbo , Yu Hai‐Sui 
Published: February 2020

SummaryA cavity expansion–based solution is proposed in this paper for the interpretation of CPTu data under a partially drained condition. Variations of the normalized cone tip resistance, cone factor, and undrained‐drained resistance ratio are examined with different initial specific volume and overconsolidation ratio, based on the exact solutions of both undrained and drained cavity expansion in CASM, which is a unified state parameter model for clay and sand. A drainage index is proposed to represent the partially drained condition, and the critical state after expansion and stress paths of cavity expansion are therefore predicted by estimating a virtual plastic region and assuming a drainage‐index–based mapping technique. The stress paths and distributions of stresses and specific volume are investigated for different values of drainage index, which are also related to the penetration velocity with comparisons of experimental data and numerical results. The subsequent consolidation after penetration is thus predicted with the assumption of constant deviatoric stress during dissipation of the excess pore pressure. Both spherical and cylindrical consolidations are compared for dissipation around the cone tip and the probe shaft, respectively. The effects of overconsolidation ratio on the stress paths and the distributions of excess pore pressure and specific volume are then thoroughly investigated. The proposed solution and the findings would contribute to the interpretation of CPTu tests under a random drained condition, as well as the analysis of pile installation and the subsequent consolidation.
Brain activation patterns of female multiple sclerosis patients with voiding dysfunction
Authors: Khavari Rose , Chen Jessie , Boone Timothy , Karmonik Christof 
Published: February 2020

AbstractAimsWe compared brain activation patterns between female multiple sclerosis (MS) patients with voiding dysfunction (VD) and those without. We aim to expand current knowledge of supraspinal correlates of voiding initiation within a cohort of female MS patients with and without VD.Materials and MethodsTwenty‐eight ambulatory female MS patients with stable disease and lower urinary tract dysfunction were recruited for this study. Subjects were divided into group 1, without VD (n = 14), and group 2, with VD (n = 14), defined as postvoid residual urine of ≥40% of maximum cystometric capacity or need for self‐catheterization. We recorded brain activity via functional magnetic resonance imaging (fMRI) with simultaneous urodynamic testing. Average fMRI activation maps (the Student t test) were created for both groups, and areas of significant activation were identified (P < .05). A priori regions of interest (ROIs), identified by prior meta‐analysis to be involved in voiding, were selected.ResultsGroup‐averaged blood‐oxygen level‐dependent (BOLD) activation maps demonstrated significant differences between groups 1 and 2 during initiation of voiding with group 2 showing significantly lower levels of activation in all ROIs except for the left cerebellum and right cingulate gyrus. Interestingly, group 2 displayed negative BOLD signals, while group 1 displayed positive signals in the right and left pontine micturition center, right periaqueductal gray, left thalamus, and left cingulate gyrus. The activation map of group 1 was similar to healthy controls.ConclusionsOur results support the hypothesis that distinct supraspinal activation patterns exist between female MS patients with VD and those without.
Eine kurze Geschichte der Rahmenbrücken in Deutschland
Authors: Pak Daniel , Seidl Günter 
Published: February 2020

AbstractStählerne Rahmenbrücken kommen in Deutschland bereits seit Anfang des letzten Jahrhunderts zum Einsatz. Wurden die ersten stählernen Rahmen noch genietet, konnten Anfang der 1940er‐Jahre mit geschweißten, vollwandigen Zweigelenkrahmenbrücken bereits Spannweiten bis 50 m realisiert werden. Mit ihrer Schlankheit kamen sie u. a. dann zum Einsatz, wenn gestiegene Anforderungen an die Verkehrslasten einen Ersatzneubau erforderten. Waren die Lagerungsbedingungen von den zunächst errichteten Zweigelenkrahmenbrücken noch klar definiert, so erforderte der Bau von Brücken mit integralen Widerlagern die Entwicklung neuer Ansätze zur Berücksichtigung der Boden‐Bauwerk‐Interaktion. Heute sind Rahmenbrücken wegen der großen realisierbaren Spannweite, welche den Mittelpfeiler bei Autobahnüberführungen überflüssig macht, sowie ihrer geringen Lebenszykluskosten zu einer wirtschaftlichen Alternative geworden. Die hier vorgestellte kurze Geschichte der Rahmenbrücken erhebt keinen Anspruch auf Vollständigkeit, soll jedoch an ausgewählten Beispielen die Entwicklung in den letzten 100 Jahren anschaulich nachzeichnen.
Rock outcrops change infiltrability and water flow behavior in a karst soil
Authors: Zhao Zhimeng , Shen Youxin , Jiang Ruohan , Wang Qinghe 
Published: February 2020

AbstractRock outcrops are widespread across the surface of the earth, particularly in karst environments, and they play an important role in infiltration‐runoff processes by triggering preferential flow. However, the characteristics of the preferential flow network at the soil–rock interface and its influencing factors in karst areas remain poorly understood. To clarify how the emergence of outcrops on the land surface affects soil infiltrability and water flow behavior, soil hydraulic conductivity (K) measurements and dye tracing experiments were conducted in a karst area with two contrasting surface features (i.e., rock outcrop plot [RP] and non‐rock‐outcrop plot [NRP]) in Yunnan Province, Southwest China. Results showed that (i) in the immediate vicinity of rock outcrops in the RP, K values were significantly increased, and other soil properties and plants were also improved when compared with results 1 m away from outcrops and in the NRP; and (ii) in the RP, the soil–rock interface dominated the preferential flow network surrounding outcrops, and the connected conduits produced by plant roots and soil fauna were also involved in this infiltration process. Matrix flow was the dominant flow behavior in the NRP. We concluded that rock outcrops, by improving soil properties and building a well‐connected preferential flow network, can greatly change infiltrability and water flow behavior in karst soil. This implied that outcrops will facilitate quick infiltration after most rainfall events and thus reduce rain‐induced surface runoff and soil erosion, as well as increasing groundwater recharge and the water supply to nearby plants.
Model exploration using conditional visualization
Authors: Hurley Catherine B. 
Published: February 2020

AbstractIdeally, statistical parametric model fitting is followed by various summary tables which show predictor contributions, visualizations which assess model assumptions and goodness of fit, and test statistics which compare models. In contrast, modern machine‐learning fits are usually black box in nature, offer high‐performing predictions but suffer from an interpretability deficit. We examine how the paradigm of conditional visualization can be used to address this, specifically to explain predictor contributions, assess goodness of fit, and compare multiple, competing fits. We compare visualizations from techniques including trellis, condvis, visreg, lime, partial dependence, and ice plots. Our examples use random forest fits, but all techniques presented are model agnostic.This article is categorized under:
Statistical and Graphical Methods of Data Analysis > Statistical Graphics and Visualization
Statistical Learning and Exploratory Methods of the Data Sciences > Exploratory Data Analysis
Statistical Learning and Exploratory Methods of the Data Sciences > Modeling Methods
Effective Quantum Field Theory for the Thermodynamical Bethe Ansatz
Authors: Kostov Ivan 
Published: February 2020

Abstract
We construct an effective Quantum Field Theory for the wrapping effects in 1+1 dimensional models of factorised scattering. The recently developed graph-theoretical approach to TBA gives the perturbative desctiption of this QFT. For the sake of simplicity we limit ourselves to scattering matrices for a single neutral particle and no bound state poles, such as the sinh-Gordon one. On the other hand, in view of applications to AdS/CFT, we do not assume that the scattering matrix is of difference type. The effective QFT involves both bosonic and fermionic fields and possesses a symmetry which makes it one-loop exact. The corresponding path integral localises to a critical point determined by the TBA equation.
The high covalence of metal-ligand bonds as stability limiting factor: the case of Rh(IX)O4+ and Rh(IX)NO3
Authors: Domański Mateusz A. , Wolański Łukasz , Szarek Paweł , Grochala Wojciech 
Published: February 2020

AbstractRhodium, a 4d transition metal and a lighter analogue of iridium, is known to exhibit its highest VIth oxidation state in RhF6 molecule. In this report, the stability and decomposition pathways of two species containing rhodium at a potentially formal +IX oxidation state, [RhO4]+ and RhNO3, have been investigated theoretically within the framework of the relativistic two-component Hamiltonian calculations. Possible rearrangement into isomers featuring lower formal oxidation numbers has been explored. We found that both species studied are metastable with respect to elimination of O2 or NO. However, the local minima containing Rh(IX) are protected by sufficient energy barriers on the decomposition pathway, and they could in principle be prepared. The analysis of a broader set of compounds containing group 8 and 9 metals in high formal oxidation states that correspond to the group number showed that, in contrast to a standard trend, the limits of formally attainable oxidation state correlate with high level of covalent bonding character in the complexes studied.
A Deep Neural Network Model of Global Topside Electron Temperature Using Incoherent Scatter Radars and Its Application to GNSS Radio Occultation
Authors: Hu Andong , Carter Brett , Currie Julie , Norman Robert , Wu Suqin , Zhang Kefei 
Published: February 2020

AbstractThe goal of this study is to present a new model for global topside electron temperature (
) using a deep neural network (DNN) that is trained using measurements from incoherent scatter radars (ISRs). This study is also an investigation into whether this model can be used to generate the electron temperature in the topside ionosphere using GNSS ionospheric radio occultation (GNSS‐IRO) data as the input. ISR is one of the most reliable and long‐term sources to measure topside ionospheric electron density and plasma temperature information simultaneously. However, a drawback of ISR databases is the relatively poor spatial coverage due to the low number of ISR stations around the world. In contrast, GNSS‐IRO can be used to measure the global distributed electron density, but
information is not directly detected. The relationship between the electron density and the electron temperature has been investigated by many researchers, but these studies have not explicitly considered the parameters that are known to influence the electron temperature, such as solar and geomagnetic activity level, and the features of electron density profile (
,
, and scale height). This study uses a DNN technique to create a new global topside electron temperature model from three submodels that have been trained using data from three ISR stations: Arecibo (low latitude), Millstone Hill (midlatitude), and Poker Flat (high latitude). This global model is trained using electron density profile information (e.g., vertical scale height [VSH],
2, and
2) and solar and geomagnetic activity (
and
, respectively) in addition to traditional spatial and temporal variables (e.g., local time, month, and latitude) as the independent variables. After the
model is developed,
information can be generated from the GNSS‐IRO electron density profiles using a newly created
model. This model's outputs are assessed with regard to out‐of‐sample ISR data and compared to the latest International Reference Ionosphere model. It is found that the electron temperature profiles from the DNN have a root‐mean‐square deviation of 259 K in the low‐latitude region (i.e., against Arecibo data), 254 K in the midlatitude region (i.e., against Millstone Hill data), and 314 K in high‐latitude region (i.e., against Poker Flat data), and all of them are smaller than the root‐mean‐square deviation from International Reference Ionosphere. An additional comparison between the model results versus the Thermosphere‐Ionosphere‐Electrodynamics General Circulation Model outputs is also conducted. A statistical analysis of the diurnal electron temperature profiles obtained from GNSS‐IRO is shown to agree with the Thermosphere‐Ionosphere‐Electrodynamics General Circulation Model outputs. The full codes and outputs can be found at the Zenodo (10.5281/zenodo.3637617).
Modes of (FACs) Variability and Their Hemispheric Asymmetry Revealed by Inverse and Assimilative Analysis of Iridium Magnetometer Data
Authors: Shi Yining , Knipp Delores J. , Matsuo Tomoko , Kilcommons Liam , Anderson Brian 
Published: February 2020

AbstractWe determine the primary modes of field‐aligned current (FAC) variability and their hemispheric asymmetry by nonlinear regression analysis of a multiyear global data set of Iridium constellation engineering‐grade magnetometer data from the Active Magnetosphere and Planetary Electrodynamics Response Experiment program. The spatial and temporal FAC variability associated with three major categories of solar wind drivers, (1) slow flow, (2) high‐speed streams (HSS), (3) transient flow related to coronal mass ejections (CMEs), and (4) a combination of these, is characterized as empirical orthogonal functions (EOFs) and their time‐varying amplitude. For the combined solar wind category, the order of the modes of variability are strengthening/weakening of (1) EOF1—all FACs; (2) EOF2—Region 2 (R2) FACs; and (3) EOF3—dayside/nightside FACs. The first two EOFs are associated with solar wind coupling; EOF3 is associated with the ecliptic components of the interplanetary magnetic field (IMF). We also find hemispheric asymmetry in FACs. Northern Hemisphere EOFs show clearer spatial features and higher correlation coefficients with solar wind drivers. The Northern Hemisphere also shows higher correlation coefficients in all seasons except winter. We find transient flow EOFs to be better correlated with solar wind drivers such as IMF Bz and coupling functions, while HSS EOFs are better correlated with solar wind plasma parameters. CME‐related transient flow EOFs also show R2 FAC variabilities that are not found in other separate wind drivers. Application of the EOF analysis to the Iridium magnetometer data shows significant promise for greater understanding of geoeffectiveness of solar wind interactions with geospace.
Runups of Unusual Size: Rogueness and Variability of Swash
Authors: García‐Medina Gabriel , Özkan‐Haller H. Tuba , Ruggiero Peter , Holman Rob A. , Li Chuan 
Published: February 2020

AbstractThe occurrence of swash larger than those predicted by the Rayleigh distribution is examined using a phase‐resolved numerical model. Multiple realizations of spectral boundary conditions and beach configurations are considered in the analysis. Planar beaches characterized by surf similarity parameters between 0.3 and 0.6 are found to be more likely to produce unusually large swash. Maximum runup is found to correlate with the maximum infragravity (IG) wave height at the location of swash initiation, the landwardmost continuously wet point. The analysis is extended to beaches with bilinear profiles, where the foreshore slope is steeper than the shoaling slope. It is found that the still water level plays a controlling role in the magnitude of large swash. For these beaches it is found that the still water level with respect to the beach toe influences both the IG and shortwave height at swash initiation. Similar to the planar beach case, swash is found to be maximized when the sum of both IG and shortwave height is maximum; this occurs at toe depths 2–3 times the offshore significant wave height.
Clinical efficacy and safety of anti-PD-1/PD-L1 inhibitors for the treatment of advanced or metastatic cancer: a systematic review and meta-analysis
Authors: Sun Leitao , Zhang Leyin , Yu Jieru , Zhang Yinan , Pang Xi , Ma Chenghao , Shen Minhe , Ruan Shanming , Wasan Harpreet S. , Qiu Shengliang 
Published: February 2020

AbstractAnti-PD-1/PD-L1 inhibitors provide a survival advantage over conventional therapies for treatment of advanced or metastatic cancer. However, the factors determining which patients benefit the most from anti-PD-1/PD-L1 inhibitors are unknown, making treatment-related decisions difficult. We performed a systematic review and meta-analysis of acquired data to assess the efficacy and toxicity of anti-PD-1/PD-L1 inhibitors in advanced and metastatic cancer. A thorough search strategy was applied to identify randomised controlled trials (RCTs) in Pubmed, Embase, Cochrane, and major conferences. Studies meeting predefined selection criteria were selected, and two independent investigators performed data extraction; overall survival (OS), progression-free survival (PFS), and overall response rate were compared between anti-PD-1/PD-L1 inhibitors and control therapies. We calculated the pooled response rate and 95% CIs of all-grade and high-grade (≥3) adverse effects and evaluated the within-study heterogeneity using subgroup, sensitivity, and meta-regression analyses. In final, we included eligible 35 RCTs (21047 patients). The main estimated hazard ratios (HRs) for OS and PFS were 0.76 (0.71–0.82) and 0.81 (0.73–0.89) in a random-effects model. The anti-PD-1/PD-L1 inhibitor group had a significantly high risk for all-grade immune-related adverse events. Anti-PD-1/PD-L1 inhibitors were identified as a preferable treatment option for advanced or metastatic cancer patients who are male, aged < 65 years, current or former smokers, had no CNS or liver metastasis, had not EGFR mutation, and had high PD-L1 expression.
Exploring resveratrol dimers as virulence blocking agents – Attenuation of type III secretion in Yersinia pseudotuberculosis and Pseudomonas aeruginosa
Authors: Sundin Charlotta , Zetterström Caroline E. , Vo Duc Duy , Brkljača Robert , Urban Sylvia , Elofsson Mikael 
Published: February 2020

AbstractBacterial infections continue to threaten humankind and the rapid spread of antibiotic resistant bacteria is alarming. Current antibiotics target essential bacterial processes and thereby apply a strong selective pressure on pathogenic and non-pathogenic bacteria alike. One alternative strategy is to block bacterial virulence systems that are essential for the ability to cause disease but not for general bacterial viability. We have previously show that the plant natural product (-)-hopeaphenol blocks the type III secretion system (T3SS) in the Gram-negative pathogens Yersinia pseudotuberculosis and Pseudomonas aeruginosa. (-)-Hopeaphenol is a resveratrol tetramer and in the present study we explore various resveratrol dimers, including partial structures of (-)-hopeaphenol, as T3SS inhibitors. To allow rapid and efficient assessment of T3SS inhibition in P. aeruginosa, we developed a new screening method by using a green fluorescent protein reporter under the control of the ExoS promoter. Using a panel of assays we showed that compounds with a benzofuran core structure i.e. viniferifuran, dehydroampelopsin B, anigopreissin A, dehydro-δ-viniferin and resveratrol-piceatannol hybrid displayed significant to moderate activities towards the T3SS in Y. pseudotuberculosis and P. aeruginosa.