bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery of a Lyα blob photo-ionised by a super-cluster of massive stars associated with a z = 3.49 galaxy
Authors: Zarattini S. , Rodríguez-Espinosa J. M. , Muñoz-Tuñón C. , Mas-Hesse J. M. , Arrabal Haro P. 
Published: December 2024

Aims. We report the discovery and characterisation of a Lyman α (Lyα) blob close to a galaxy at redshift z = 3.49. We present the analysis we performed to check whether the companion galaxy could be the source of the ionised photons responsible for the Lyα emission from the blob.
Methods. We used images obtained from the 10.4 m Gran Telescopio Canarias (GTC) telescope that are part of the Survey of High-z Absorption Red and Dead Sources (SHARDS) project. The blob is only visible in the F551W17 filter, centred around the Lyα line at the redshift of the galaxy. We measured the luminosity of the blob with a two-step procedure. Here, we start with a description of the radial surface-brightness (SB) profile of the galaxy, using a Sérsic function. We then removed this model from the SB profile of the blob and measured the luminosity of the blob alone. We also estimated the Lyα continuum of the galaxy using an Advanced Camera for Surveys (ACS) image from the Hubble Space Telescope (HST) in the F606W filter, which is wider than the SHARDS one and centred at about the same wavelength. In this image, the galaxy is visible, but the blob is not detected, since its Lyα emission is diluted in the larger wavelength range of the F606W filter.
Results. We find that the Lyα luminosity of the blob is 1.0 × 1043 erg s−1, in agreement with other Lyα blobs reported in the literature. The luminosity of the galaxy in the same filter is 2.9 × 1042 erg s−1. The luminosity within the HST/ACS image that we used to estimate the Lyα continuum emission is Lcont = 1.1 × 1043 erg s−1. With these values, we have been able to estimate the Lyα equivalent width (EW), found to be 111 Å (rest-frame). This value is in good agreement with the literature and suggests that a super-cluster of massive (1 − 2 × 107 M⊙) and young (2 − 4 Myr) stars could be responsible for the ionisation of the blob. We also used two other methods to estimate the luminosity of the galaxy and the blob to assess the robustness of our results. We find a reasonable agreement that supports our conclusions. It is worth noting that the Lyα blob is spatially decoupled from the galaxy by 3 GTC/SHARDS pixels, corresponding to 5.7 kpc at the redshift of the objects. This misalignment could suggest the presence of an ionised cone of material escaping from the galaxy, as found in nearby galaxies such as M 82.
4FGL J1544.2−2554: A new spider pulsar candidate
Authors: Karpova A. V. , Zharikov S. V. , Zyuzin D. A. , Kirichenko A. Yu. , Shibanov Yu. A. , Márquez I. F. 
Published: December 2024

Context. Spider pulsars are millisecond pulsars in tight binary systems in which a low-mass companion star is heated and ablated by the pulsar wind. Observations of these objects allow one to study stellar evolution with the formation of millisecond pulsars and the physics of superdense matter in neutron stars. However, spiders are rare due to difficulties related to their discovery when using typical radio search techniques. The Fermiγ-ray source 4FGL J1544.2−2554 was recently proposed as a pulsar candidate, and its likely X-ray and optical counterparts, with the galactic coordinates l ≈ 344.​​°76, b ≈ 22.​​°59 and the magnitude G ≈ 20.6, were found using the eROSITA and Gaia surveys.
Aims. Our goals are to study whether the source is a new spider pulsar and to estimate its fundamental parameters.
Methods. We performed the first optical time series multi-band photometry of the object. We used the Lomb-Scargle periodogram to search for its brightness periodicity and fitted its light curves with a model of direct heating of the binary companion by the pulsar wind.
Results. The source shows a strong brightness variability with a period of ≈2.724 h and an amplitude of ≳2.5 mag, and its light curves have a single broad peak per period. These features are typical for spider pulsars. The curves are well fitted by the direct heating model, resulting in an orbit inclination of the presumed spider system of ≈83°, a companion mass of ≈0.1 M⊙, ‘day-side’ and ‘night-side’ temperatures of ≈7200 K and ≈3000 K, a Roche lobe filling factor of ≈0.65, and a distance of ≈2.1 kpc.
Conclusions. Our findings suggest that 4FGL J1544.2−2554 is a spider pulsar. This result encourages the search for pulsar millisecond pulsations in radio and γ-rays to confirm its nature.
CARMENES input catalogue of M dwarfs
Authors: Cifuentes C. , Caballero J. A. , González-Payo J. , Amado P. J. , Béjar V. J. S. , Burgasser A. J. , Cortés-Contreras M. , Lodieu N. , Montes D. , Quirrenbach A. , Reiners A. , Ribas I. , Sanz-Forcada J. , Seifert W. , Zapatero Osorio M. R. 
Published: December 2024

Context. Multiplicity studies greatly benefit from focusing on M dwarfs because they are often paired in a variety of configurations with both stellar and substellar objects, including exoplanets.
Aims. We aim to address the observed multiplicity of M dwarfs by conducting a systematic analysis using the latest available astropho-tometric data.
Methods. For every star in a sample of 2214 M dwarfs from the CARMENES catalogue, we investigated the existence of resolved and unresolved physical companions in the literature and in all-sky surveys, especially in Gaia DR3 data products. We covered a very wide range of separations, from known spectroscopic binaries in tight arrangements (~0.01 au) to remarkably separated ultra-wide pairs (~105 au).
Results. We identified 835 M dwarfs in 720 multiple systems, predominantly binaries. Thus, we propose 327 new binary candidates based on Gaia data. If these candidates are finally confirmed, we expect the multiplicity fraction of M dwarfs to be 40.3−2.0+2.1%. When only considering the systems already identified, the multiplicity fraction is reduced to 27.8−1.8+1.9%. This result is in line with most of the values published in the literature. We also identified M-dwarf multiple systems with FGK, white dwarf, ultra-cool dwarf, and exoplanet companions, as well as those in young stellar kinematic groups. We studied their physical separations, orbital periods, binding energies, and mass ratios.
Conclusions. We argue that based on reliable astrometric data and spectroscopic investigations from the literature (even when considering detection biases), the multiplicity fraction of M dwarfs could still be significantly underestimated. This calls for further high-resolution follow-up studies to validate these findings.
Messung von Einstellungen zur Versorgungsforschung von
Vertreter:innen deutscher Rehabilitationseinrichtungen: Die REHA-KNOWS
Studie
Authors: Fichtner Urs Alexander , Wimmesberger Nicole , Sehlbrede Matthias , Farin-Glattacker Erik 
Published: December 2024

Zusammenfassung
Ziel Die REHA-KNOWS-Studie exploriert die Wahrnehmung von
Praxisvertreter:innen südwestdeutscher Rehabilitationseinrichtungen hinsichtlich
(Versorgungs-)Forschung und zeigt Nutzen und Barrieren im Wissenstransfer aus
Sicht der Praxis auf. Hierfür wurde ein Instrument mit 12 5-stufigen Items
entwickelt, das in dieser Arbeit explorativ untersucht wird. Das Instrument
umfasst Aussagen über Nutzen, Aufwand und Mehrwert von Reha-Forschungsprojekten
sowie über Rahmenbedingungen in den Einrichtungen. Von März bis Mai 2023 wurden
Daten von Verterter:innen aus 206 Reha-Einrichtungen in Baden-Württemberg und im
Saarland mithilfe eines Online-Fragebogens gesammelt.
Methodik Es erfolgte eine deskriptive Analyse der
Verteilungseigenschaften. Weiterhin wurde eine explorative Faktorenanalyse
mittels Parallelanalyse nach Horn sowie Veliciers Minimum Average Partial zur
Bestimmung der zugrundeliegenden Faktorstruktur und Eindimensionalität
durchgeführt. Außerdem wurden Mann-Whitney-U-Tests berechnet zur Ermittlung von
Unterschieden in den Antworten zwischen den Vertreter:innen aus den Bereichen
Medizin, Pflege und Therapie und Personal mit administrativen und
Managementaufgaben.
Ergebnisse Insgesamt wies das Instrument wenige fehlende Werte bei einer
akzeptablen Streuung und geringer Itemschwierigkeit auf. Boden- und
Deckeneffekte waren vernachlässigbar gering, traten aber bei drei Items auf.
Unterschiede im Antwortverhalten zwischen den Berufsgruppen ergaben sich
deskriptiv für die Items 2, 10 und 12. Diese waren jedoch unter Berücksichtigung
von multiplem Testen nicht signifikant. Vier Items wurden aufgrund schlechter
Eignung aus der Faktorenanalyse ausgeschlossen, die dann eine einfaktorielle
Lösung mit 31% Varianzaufklärung ergab. Der Fit für das Gesamtmodell zur Prüfung
der Eindimensionalität ist als unbefriedigend einzustufen. Der identifizierte
Faktor lässt sich als „Einstellung gegenüber dem Nutzen von Forschung für die
Praxis” beschreiben. Die Antworten auf die offene Frage nach den bisherigen
Erfahrungen mit Forschungsaktivitäten geben Hinweise darauf, dass weitere Items
generiert werden sollten, die das Kosten-Nutzen-Verhältnis mit Schwerpunkt auf
die monetäre Vergütung des anfallenden (Personal-)Aufwands abdecken sollten.
Schlussfolgerung Das neu entwickelte Instrument setzt einen Grundstein zur
systematischen Erfassung von Einstellungen von Vertreter:innen von
Reha-Einrichtungen gegenüber (Versorgungs-)Forschung. Es bedarf weiterer
Studien, um das Messinstrument zum Erheben dieser komplexen Thematik zu
verbessern.
Berufliche Teilhabe nach medizinischer Rehabilitation aufgrund
psychischer Erkrankungen: Repräsentative Analysen auf Basis der
Routinedaten der Deutschen Rentenversicherung
Authors: Streibelt Marco , Matthies Claudia , Zollmann Pia 
Published: December 2024

Zusammenfassung
Ziel der Studie Die besondere Relevanz psychischer Störungen für
Gesellschaft und Wirtschaft zeigt sich in der Betrachtung der beruflichen
Teilhabe. Das Ziel unserer Studie ist, basierend auf repräsentativen
Routinedaten der Rentenversicherung, die Gruppe der Rehabilitand*innen einer
psychosomatischen Rehabilitation aus dem Jahr 2017 anhand ausgewählter Merkmale
zu beschreiben, die Return to Work (RTW)-Quoten sowie die individuellen Verläufe
nach der Rehabilitation zu betrachten und mögliche Einflussfaktoren zu
identifizieren.
Methodik Berufliche Teilhabe wurde sowohl über eine monatliche
Zustandsvariable bis 24 Monate nach der Rehabilitation als auch als Quote aller
Personen, die nach 12 oder 24 Monaten im Erhebungsmonat und den 3 vorhergehenden
Monaten sozialversicherungspflichtig beschäftigt waren, operationalisiert. Für
die Analyse der Einflussfaktoren auf stabile berufliche Teilhabe wurden multiple
logistische Regressionsmodelle mit schrittweisem Einschluss, getrennt für die
Quoten nach 12 und 24 Monaten, kalkuliert.
Ergebnisse Insgesamt wurden 122 623 Datensätze in die Analyse einbezogen
(darunter Depressive Episode (DE): n=28 497, 23,2%, Rezidivierende depressive
Störungen (RD): n=42 573, 34,7%; Reaktionen auf schwere Belastungen und
Anpassungsstörungen (BR): n=19 122, 15,6%; Angststörungen (AS): n=9716, 7,9% und
Somatoforme Störungen (SO): n=8564, 7,0%). Das Durchschnittsalter lag bei 50
Jahren, 64% waren weiblich. Es zeigten sich unterschiedliche Verläufe je nach
Indikation, mit stabilen Beschäftigungsquoten nach 12 Monaten von 69% bei der
Gruppe BR; 62% DE; 61% SE; 57% RD bis zu 52% SO. Einflussfaktoren auf stabile
Beschäftigung nach einem Jahr waren die Dauer der Arbeitsunfähigkeit im Jahr vor
der Rehabilitation, die Existenz eines Beschäftigungsverhältnisses, sowie ein
hohes Einkommen.
Schlussfolgerung Da sich die relevanten Veränderungen in den ersten 6
Monaten nach der Rehabilitation zeigten, sollten weitere
Unterstützungsleistungen von Menschen mit psychischen Erkrankungen nach einer
medizinischen Rehabilitation möglichst früh nach dieser ansetzen.
A Survey of 251 Facial Paralysis Patients to Assess Their Educational Preparedness and Symptom Management after Treatment of Vestibular Schwannoma
Authors: Barkhoudarian Garni , Sivakumar Walavan , Voelker Courtney J. , Gowrinathan Shanthi , Sharma Akanksha , Li Hsin-Fang , Kochhar Amit 
Published: December 2024

Abstract
Objective The aim of this study was to evaluate how patients with vestibular schwannoma (VS) were prepared for facial paralysis (FP).
Study Design This study comprised an online survey of members of the Acoustic Neuroma Association of America who had FP.
Methods A 28-question survey gathering information on the patient experience related to management of FP was created. Associations between treatment setting and presence of FP were analyzed using SAS Enterprise Guide 8.4. Significance was considered at p-values < 0.05 in a univariate and multivariable model.
Results A total of 251 subjects with VS and FP responded. A total of 14% presented with FP, 70% were diagnosed with VS at least 6 months prior to treatment, and 61% were treated at academic centers. A total of 28% felt prepared for life with FP and 42% were confident their medical team understood management. Less than 30% of respondents received educational materials. After developing FP, speech and swallow difficulty and anxiety were common, but few respondents were referred for expert management. Subjects at academic centers were more often referred to specialists in the same location. Those with preoperative FP felt their medical teams better prepared them for it, had fewer complaints of difficulty speaking, and were happier with their recovery.
Conclusion Significant gaps in preparation and management of FP were identified. Preoperative FP led to improved perception of care; however, the delivery was similar to those without it. Studies of surgeons who manage VS are needed to better understand how they prepare patients for the emotional and physical sequelae of FP.
Outcomes in Neonates Receiving Therapeutic Hypothermia and Extracorporeal Membrane Oxygenation versus Extracorporeal Membrane Oxygenation Alone
Authors: Cicalese Erin , Seltzer Bryn H.S. , Fisher Jason C. , Verma Sourabh 
Published: December 2024

Objective This study aimed to examine survival and outcomes in neonates who received therapeutic hypothermia (TH) for neonatal encephalopathy (NE) and extracorporeal membrane oxygenation (ECMO) versus ECMO alone.
Study Design This is a retrospective review of Extracorporeal Life Support Organization (ELSO) Registry data from 2007 to 2017 for neonates undergoing ECMO and TH for NE (TH/ECMO) or ECMO alone. Primary outcomes were ECMO survival and survival to discharge. Secondary outcomes were complications while on ECMO. Statistical analysis was performed using Fisher's exact and Mann–Whitney U tests. Multivariate regression was performed to identify predictors of ECMO survival.
Results Of 3,672 neonates, 215 (6%) received TH/ECMO, while 3,457 (94%) received ECMO alone. There was no significant difference in ECMO survival (92 vs. 92%, p = 0.70) or survival to discharge (87 vs. 85%, p = 0.43) between groups. TH/ECMO group had higher hemorrhagic (29 vs. 20%, p < 0.01), neurologic (24% vs. 12%, p < 0.01), and metabolic (28 vs. 15%, p < 0.01) complications. Multivariate regression identified higher gestational age, absence of inotropes during ECMO, and lack of neurologic, pulmonary, or hemorrhagic complications as independent predictors of ECMO survival.
Conclusion Neonates undergoing ECMO and TH for NE had survival rates comparable to those receiving ECMO alone. These findings suggest that ECMO can be considered for neonates with NE undergoing TH who meet the criteria for ECMO.
Key Points
Visible-Light-Induced Acridinium-Catalyzed Acylation of Isoquinolines with Aldehydes via HAT
Authors: Singh Praveen P. , Singh Satya Prakash , Mishra Mangla , Tivari Shraddha , Singh Pravin K. , Srivastava Vishal 
Published: December 2024

AbstractA novel synthetic method utilizes visible light to promote acridinium-catalyzed acylation of substituted isoquinoline via aldehydes in an air atmosphere at room temperature is reported. This method involves the formation of C–C bonds to synthesize the desired product with an excellent yield. This organophotoredox-catalyzed, transition-metal-free synthetic process provides the target compounds in an immensely sustainable manner despite tolerating a broad range of functional groups.
Synthesis of Silyl Heterocycles Using Transborylation
Authors: Willcox Dominic R. 
Published: December 2024

AbstractSilicon has been proposed as a nonclassical bioisostere to carbon in a ‘silicon-switch’ approach, however, the synthesis of complex molecules containing silyl heterocycles is still a significant challenge in preparing ‘silicon-switch’ molecules. Transborylation, the σ-bond metathesis between two boron species, has been utilized for the synthesis of complex molecules, in an orthogonal approach to transition-metal catalysis. Here, the use of transborylation catalysis for the synthesis of structurally diverse silyl heterocycles is highlighted.1	Introduction2	Transborylation in Catalysis3	Silyl Heterocycles4	Synthesis of Silyl Heterocycles Using Transborylation5	Conclusions and Outlook
A Free-Radical Decarboxylative Coupling of Cinnamic Acids with Acetonitrile
Authors: Shang Xiao-Jie , Liu Zhong-Quan , Chu Run , Luo Rui , Zhang Yanjiang 
Published: December 2024

AbstractA copper-catalyzed decarboxylative coupling of cinnamic acids with acetonitrile was developed. By using the free-radical hydrogen-atom-transfer strategy to activate the C–H bond in acetonitrile, a series of nitrile compounds were successfully synthesized. This method uses the common solvent acetonitrile as a source of a nitrile group for introduction into organic molecules, avoiding the use of highly toxic nitriles in conventional nitrile compound syntheses.
Synthesis, Characterization, and In Vitro and In Silico Biological Evaluation of Novel Polyphenols Bearing a Quinazolin-4(3H)-one Ring as Promising Anti-Prostate-Cancer Agents
Authors: Şenol Halil , Tokalı Feyzi Sinan , Çağman Zeynep , Çakır Furkan 
Published: December 2024

AbstractIn this study, 12 novel polyphenols containing the quinazolin-4(3H)-one ring were synthesized and characterized using 1H/13C NMR and HRMS analyses, yielding the target compounds in excellent yields (88–96%). Biological evaluation revealed significant cytotoxic activity against PC3 prostate cancer and 3T3 fibroblast cell lines, with compounds 2,2′-(propane-1,3-diyl)bis-3-(2,4-dihydroxybenzylideneamino)quinazolin-4(3H)-one (5) and 2,2′-(propane-1,3-diyl)bis-3-(2,3,4-trihydroxybenzylideneamino)quinazolin-4(3H)-one (6) demonstrating the highest anticancer potential. Compound 6 exhibited the highest selectivity (IC50 = 5.72 µM, SI = 68), outperforming the reference drug, doxorubicin. In silico studies, including molecular docking and dynamics simulations, showed strong binding affinities for mTOR, P110α, and PARP1, particularly for compound 6. Key interactions, such as hydrogen bonds and π-π stacking, contributed to the stability of the 6–mTOR complex. These results highlight compounds 5 and 6 as promising candidates for prostate cancer therapy, with compound 6 showing superior selectivity and interaction profiles, providing the groundwork for further preclinical development.
Enzymatic Peroxidation in the Chemoenzymatic Synthesis of 13-Oxoverruculogen
Authors: Ting Chi P. , Singh Brandon 
Published: December 2024

AbstractVerruculogens are fumitremorgin alkaloids that contain an eight-membered endoperoxide ring. Due to their unusual structure and bioactivity, there has been much interest in these natural products since their discovery over forty years ago. Similarly, interest in their biosynthesis resulted in the discovery of verruculogen synthase (FtmOx1) that catalyzes endoperoxide formation in these natural products. Herein, we describe our work in this area through the chemoenzymatic synthesis of 13-oxoverruculogen by endoperoxidation of a substrate analogue using FtmOx1.1	Introduction2	Pentacyclic Ring Formation3	Promiscuous Enzymatic Peroxidation4	Conclusion
C–H Functionalization of Quinoxalines
Authors: Laru Sudip , Ghosh Sumit , Hajra Alakananda 
Published: December 2024

AbstractAs a powerful tool in modern organic synthesis, C–H functionalization offers an elegant shortcut to molecular complexity, enabling direct bond transformations without any pre-functionalization. In this connection, the C–H functionalization of quinoxalines offers a direct and efficient approach to modify the quinoxaline scaffold, a key structural motif in biologically active compounds and materials. This personal account describes the methodologies developed by our group for the C–H activation and functionalization of quinoxaline compounds.1	Introduction2	Difluoroalkylamidation3	ortho C–H Alkylation4	ortho C–H Amination5	Conclusion
Impact of Systemic Lupus Erythematosus on Conception: Insights into Infertility, Fertility Preservation, Assisted Reproductive Technology, and Pregnancy Outcomes
Authors: Moyer Amanda , Edens Cuoghi 
Published: December 2024

AbstractMany individuals with systemic lupus erythematosus (SLE) face significant challenges manifesting their family planning goals due to numerous factors, including disease-related complications, treatment-induced effects, immunological factors, self-imposed limitations, and the socioeconomic impacts of having a chronic disease. Instances of unexplained infertility are also prevalent. Encouragingly, advancements in treatment modalities, risk factor management, specialized training within the medical community, and enhanced patient/provider education have contributed to an increase in successful pregnancies among SLE patients, fostering a safer, more promising reproductive landscape. However, despite advances, individuals with SLE continue to struggle with the complexities of family building. This review explores infertility and pregnancy outcomes in SLE, fertility preservation, the role of assisted reproductive technology, and considerations for tailoring these approaches to SLE patients.
Management of Febrile Infants Under 3 Months of Age with SARS-CoV-2 Infection in the Emergency Department
Authors: Diego Patricia , Seguí Aina , Trenchs Victoria , Luaces Carles , Hernández-Bou Susanna 
Published: December 2024

Abstract
Objective Febrile infants with a proven viral infection are at lower risk for a potentially serious bacterial infection (SBI). Our objective is to describe the management of young febrile infants with COVID-19 in the emergency department.
Methods Febrile infants <3 months with a positive PCR (polymerase chain reaction) test for SARS-CoV-2 between March 2020 and October 2022 were included in a cross-sectional study. The indication for complementary tests, hospital admission and antibiotic therapy was analyzed. We performed a global analysis and by age subgroups (<29 d and ≥29 d).
Results A total of 172 patients were included in the study, out of which 32 (18.6%) were <29 days old. Bacterial cultures were performed on 160 patients (93%), with urine cultures being the most frequently requested (151 patients; 87.8%). Overall, 39 infants (22.7%) were hospitalized, and 17 infants (9.9%) received antibiotics. In the subgroup analysis, patients <29 days had performed more frequently urine culture (100 vs. 85%; p = 0.015), blood culture (96.9 vs. 43.6%; p < 0.001), and cerebrospinal fluid culture (18.8 vs. 1.4%; p < 0.001). They also had a higher admission rate (68.8 vs. 12.1%; p < 0.001) and antibiotic prescription (21.9 vs. 7.1%; p = 0.02). SBI was identified in 10 patients (9 with urinary infections and 1 with bacteremia), while no invasive bacterial infection (IBI) was diagnosed in patients aged ≥29 days.
Conclusions The identification of SARS-CoV-2 led to less aggressive management in a significant number of cases compared with usual practice. The low prevalence of IBI would support its inclusion in the management algorithms for febrile infants, especially in patients aged ≥29 days. The nonnegligible prevalence of urinary infection would make it necessary to maintain its screening.