bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peer Mentors for People with Advanced Cancer: Lessons Learnt from Recruiting and Training Peer Mentors for a Feasibility Randomized Controlled Trial
Authors: Walshe Catherine , Roberts Diane , Calman Lynn , Appleton Lynda , Croft Robert , Perez Algorta Guillermo , Skevington Suzanne , Lloyd-Williams Mari , Grande Gunn 
Published: January 2020

AbstractPeer mentors may offer distinctive forms of support to people with advanced cancer. Whilst peer mentor programmes are known, little is understood about recruiting and training peer mentors to support those with advanced cancer. The purpose of this study is to determine the feasibility of recruiting and training peer mentors for a novel peer mentor intervention to promote well-being in people with advanced cancer. Feasibility study testing proactive introduction to a trained peer mentor for 12 weeks in the context of a randomized controlled two-arm trial and nested qualitative process evaluation was used. Peer mentors have/had cancer, recruited via an open call. Two-day training included a new bespoke module on coping with cancer. Descriptive recruitment and training data were captured, supplemented by qualitative interviews, analysed thematically. Forty-eight people expressed interest, mostly female (69%), with breast cancer (32%), and recruited via social media (49%). Twelve people completed training, with attrition often due to availability or mentors’ own health; many had advanced cancer themselves. They wanted to ‘give something back’, but also formed supportive bonds with fellow mentors. It is feasible to recruit and train people with lived experience of cancer to be peer mentors, but those with particular characteristics may predominate. Broad social media based recruitment may have merit in widening the pool of potential peer mentors.
Advancing health equity through CTSA programs: Opportunities for interaction between health equity, dissemination and implementation, and translational science
Authors: Yousefi Nooraie Reza , Kwan Bethany M. , Cohn Elizabeth , AuYoung Mona , Clarke Roberts Megan , Adsul Prajakta , Shelton Rachel C. 
Published: January 2020

AbstractDissemination and implementation (D&I) science is dedicated to studying how to effectively translate and apply research in real-world contexts. There has been increasing interest in health equity within the D&I field to ensure the equitable implementation of evidence-based programs/practices across a range of diverse populations and settings. At the same time, health equity researchers recognize the potential of D&I science to promote the more widespread dissemination, implementation, and sustainment of evidence-based interventions to address health inequities. The National Center for Accelerating Clinical and Translational Science Clinical and Translational Science Award (CTSA) Program has been a champion for community engagement and translational scholarship in its mission to improve individual and population health. The overall CTSA infrastructure and resources within and among CTSA hubs are well-equipped to facilitate a health equity focus to D&I across the phases of translational research. This paper proposes a framework that demonstrates the interaction and opportunities between health equity and D&I science and highlights how CTSAs can support and facilitate wider efforts in translational research with a focus on equitable D&I.
Timely interventions: Temporality and peacebuilding
Authors: Christie Ryerson , Algar-Faria Gilberto 
Published: January 2020

AbstractWhile there has been a long engagement with the impact of time on peacebuilding policies and practice, this engagement has to date focused predominately on issues of short- versus long-term initiatives, and of waning donor support for such initiatives. More recently, the critical peacebuilding turn has focused attention on the politics of the everyday as being essential to emancipatory endeavours enacted through localisation. Yet despite this, time itself has not been the subject of analysis, and the politics of time have not been integrated into the study of peacebuilding. This article, drawing both on historical institutionalist and on critical international studies analyses of temporality, provides a framework for analysing the impacts of time on the potential to achieve emancipatory peace. Drawing on extensive fieldwork in Bosnia and Herzegovina and in Cambodia, this article asserts that a focus on Policy Time, Liberal Political Time, and Intergenerational Time highlights how peacebuilding initiatives are framed by disparate timescapes that limit the visibility of local chronopolitics, and that this in turn restricts local empowerment and resistances.
Understanding unmet health-care need among older Ghanaians: a gendered analysis
Authors: Kuuire Vincent Z. , Tenkorang Eric Y. , Amegbor Prince M. , Rosenberg Mark 
Published: January 2020

AbstractHealth insurance schemes are important for bridging gaps in health-care needs between the rich and poor, especially in contexts where poverty is higher among seniors (persons aged 65 years and above). In this study we examined (a) gender-based predictors of unmet health-care need among seniors and (b) whether access was influenced by wealth status (measured by income quintiles). Gender-specific negative log–log regression models were fitted to data from the Study on Global Ageing and Health to examine associations between unmet health-care need and health insurance status controlling for theoretically relevant covariates. Insurance status was an important determinant of men and women's unmet health-care need but the relationship was moderated by income quintile for women and not men. While occupation was important for men, religion, marital status and income quintile were significantly associated with women's unmet health-care need. Based on the observed gender differences, we recommend the implementation of programmes aimed at improving the economic situation of older people, particularly women.
Moral Distress among Disaster Responders: What is it?
Authors: Gustavsson Martina E. , Arnberg Filip K. , Juth Niklas , von Schreeb Johan 
Published: January 2020

AbstractIntroduction:Current research of moral distress is mainly derived from challenges within high-resource health care settings, and there is lack of clarity among the different definitions. Disaster responders are prone to a range of moral challenges during the work, which may give rise to moral distress. Further, organizations have considered increased drop-out rates and sick leaves among disaster responders as consequences of moral distress. Therefore, initiatives have been taken to address and understand the impacts of moral distress and its consequences for responders. Since there is unclarity among the different definitions, a first step is to understand the concept of moral distress and its interlinkages within the literature related to disaster responders.Hypothesis/Problem:To examine how disaster responders are affected by moral challenges, systematic knowledge is needed about the concepts related to moral distress. This paper aims to elucidate how the concept of moral distress in disaster response is defined and explained in the literature.Methods:The paper opted to systematically map the existing literature through the methods of a scoping review. The searches derived documents which were screened regarding specific inclusion criteria. The included 16 documents were analyzed and collated according to their definitions of moral distress or according to their descriptions of moral distress.Results:The paper provides clarity among the different concepts and definitions of moral distress within disaster response. Several concepts exist that describe the outcomes of morally challenging situations, centering on situations when individuals are prevented from acting in accordance with their moral values. Their specific differences suggest that to achieve greater clarity in future work, moral stress and moral distress should be distinguished.Conclusion:Based on the findings, a conceptual model of the development of moral distress was developed, which displays a manifestation of moral distress with the interplay between the responder and the context. The overview of the different concepts in this model can facilitate future research and be used to illuminate how the concepts are interrelated.
Transfer learning for Turkish named entity recognition on noisy text
Authors: Kağan Akkaya Emre , Can Burcu 
Published: January 2020

AbstractIn this article, we investigate using deep neural networks with different word representation techniques for named entity recognition (NER) on Turkish noisy text. We argue that valuable latent features for NER can, in fact, be learned without using any hand-crafted features and/or domain-specific resources such as gazetteers and lexicons. In this regard, we utilize character-level, character n-gram-level, morpheme-level, and orthographic character-level word representations. Since noisy data with NER annotation are scarce for Turkish, we introduce a transfer learning model in order to learn infrequent entity types as an extension to the Bi-LSTM-CRF architecture by incorporating an additional conditional random field (CRF) layer that is trained on a larger (but formal) text and a noisy text simultaneously. This allows us to learn from both formal and informal/noisy text, thus improving the performance of our model further for rarely seen entity types. We experimented on Turkish as a morphologically rich language and English as a relatively morphologically poor language. We obtained an entity-level F1 score of 67.39% on Turkish noisy data and 45.30% on English noisy data, which outperforms the current state-of-art models on noisy text. The English scores are lower compared to Turkish scores because of the intense sparsity in the data introduced by the user writing styles. The results prove that using subword information significantly contributes to learning latent features for morphologically rich languages.
Are cover crop mixtures better at suppressing weeds than cover crop monocultures?
Authors: Smith Richard G. , Warren Nicholas D. , Cordeau Stéphane 
Published: January 2020

AbstractCover crops are increasingly being used for weed management, and planting them as diverse mixtures has become an increasingly popular strategy for their implementation. While ecological theory suggests that cover crop mixtures should be more weed suppressive than cover crop monocultures, few experiments have explicitly tested this for more than a single temporal niche. We assessed the effects of cover crop mixtures (5- or 6-species and 14-species mixtures) and monocultures on weed abundance (weed biomass) and weed suppression at the time of cover crop termination. Separate experiments were conducted in Madbury, NH, from 2014 to 2017 for each of three temporal cover-cropping niches: summer (spring planting–summer termination), fall (summer planting–fall termination), and spring (fall planting–subsequent spring termination). Regardless of temporal niche, mixtures were never more weed suppressive than the most weed-suppressive cover crop grown as a monoculture, and the more diverse mixture (14 species) never outperformed the less diverse mixture. Mean weed-suppression levels of the best-performing monocultures in each temporal niche ranged from 97% to 98% for buckwheat (Fagopyrum esculentum Moench) in the summer niche and forage radish (Raphanus sativus L. var. niger J. Kern.) in the fall niche, and 83% to 100% for triticale (×Triticosecale Wittm. ex A. Camus [Secale × Triticum]) in the winter–spring niche. In comparison, weed-suppression levels for the mixtures ranged from 66% to 97%, 70% to 90%, and 67% to 99% in the summer, fall, and spring niches, respectively. Stability of weed suppression, measured as the coefficient of variation, was two to six times greater in the best-performing monoculture compared with the most stable mixture, depending on the temporal niche. Results of this study suggest that when weed suppression is the sole objective, farmers are more likely to achieve better results planting the most weed-suppressive cover crop as a monoculture than a mixture.
Once Again on Preliminary Reference Earth Model
Authors: Guliyev H. H. , Javanshir R. J. 
Published: January 2020

AbstractWe studied the isotropic ball using data of Preliminary Reference Earth Model (PREM). It is shown that such a ball should be either destructed or gone into a more stable equilibrium state with uneven distributed deformation under thermobaric condition of the inner core. Body elastic waves with real velocities cannot propagate in it. This manuscript is devoted to study the situation from the standpoint of nonlinear geomechanics. A number of necessary principles of Mechanics of Deformable Solid Body (MDSB) is given at the beginning of the analysis. A brief review of the published latest experimental work is performed. It is established that proper attention to the role of the MDSB principles in micro‐scale (nano) experiments of the physical level has not been given. Deformation properties of solid bodies are emphasized in microscale and macroscale. Application of linear acoustoelasticity and extrapolation of Birch's linear law of the inner core and use of an idea on variability of elasticity moduli with the increase of pressure and temperature have contributed to obtained pseudo data for the geological medium of the Earth's core instead of linear data on the physicomechanical properties. It is proposed that parallel to elimination of the indicated disadvantages, collection, processing and interpretation should be performed using nonclassically linearized approach. This set of necessary actions is offered as the “key” of geomechanical analysis. The proper application will allow conducting similar analysis concerning other solid‐state structures of the Earth.
Studying Sequences of Initial Breakdown Pulses in Cloud‐to‐Ground Lightning Flashes
Authors: Karunarathne Nilmini , Marshall Thomas C. , Karunarathne Sumedhe , Stolzenburg Maribeth 
Published: January 2020

AbstractThe properties of the first 5–12 classic initial breakdown pulses (IBPs) of three cloud‐to‐ground (CG) lightning flashes were determined using a modified transmission line model. As part of the modeling, the current with respect to time of each IBP was determined from the measured electric field changes at multiple sites using three theoretical methods called Hilbert transform, Hertzian dipole, and matrix inversion. In the transmission line modeling the length of each IBP was estimated from high‐speed video data of the IBPs. The modeling provided the following properties of the larger classic IBPs in each flash: peak current, velocity, total charge, charge moment, radiated power, and total energy dissipated for successive IB pulses in three developing lightning flashes. For the main initial leader channel in the three CG flashes (and for one long branch), IBP peak current was largest for the first or second classic IBP and declined mostly monotonically with successive IBPs. For the same channels, IBP current velocity was smallest for the first classic IBP and increased mostly monotonically with successive IBPs. The smallest velocities were (2.0, 2.5, 2.5, 3.0) × 107 m/s, respectively, while the largest velocities were (9.2, 12.2, 11.5, 12.0) × 107 m/s, respectively. These data support earlier hypotheses that it is the classic IB pulses during initial leader of normal negative CG flashes that change the nonconductive air into an ionized path that is sufficiently long and conductive to start the stepped leader.
Intelligent control of mode-locked femtosecond pulses by time-stretch-assisted real-time spectral analysis
Authors: Pu Guoqing , Yi Lilin , Zhang Li , Luo Chao , Li Zhaohui , Hu Weisheng 
Published: January 2020

AbstractMode-locked fiber lasers based on nonlinear polarization evolution can generate femtosecond pulses with different pulse widths and rich spectral distributions for versatile applications through polarization tuning. However, a precise and repeatable location of a specific pulsation regime is extremely challenging. Here, by using fast spectral analysis based on a time-stretched dispersion Fourier transform as the spectral discrimination criterion, along with an intelligent polarization search algorithm, for the first time, we achieved real-time control of the spectral width and shape of mode-locked femtosecond pulses; the spectral width can be tuned from 10 to 40 nm with a resolution of ~1.47 nm, and the spectral shape can be programmed to be hyperbolic secant or triangular. Furthermore, we reveal the complex, repeatable transition dynamics of the spectrum broadening of femtosecond pulses, including five middle phases, which provides deep insight into ultrashort pulse formation that cannot be observed with traditional mode-locked lasers.
Characterization of a sponge microbiome using an integrative genome-centric approach
Authors: Engelberts J Pamela , Robbins Steven J , de Goeij Jasper M , Aranda Manuel , Bell Sara C , Webster Nicole S 
Published: January 2020

Abstract
Marine sponges often host diverse and species-specific communities of microorganisms that are critical for host health. Previous functional genomic investigations of the sponge microbiome have focused primarily on specific symbiont lineages, which frequently make up only a small fraction of the overall community. Here, we undertook genome-centric analysis of the symbiont community in the model species Ircinia ramosa and analyzed 259 unique, high-quality metagenome-assembled genomes (MAGs) that comprised 74% of the I. ramosa microbiome. Addition of these MAGs to genome trees containing all publicly available microbial sponge symbionts increased phylogenetic diversity by 32% within the archaea and 41% within the bacteria. Metabolic reconstruction of the MAGs showed extensive redundancy across taxa for pathways involved in carbon fixation, B-vitamin synthesis, taurine metabolism, sulfite oxidation, and most steps of nitrogen metabolism. Through the acquisition of all major taxa present within the I. ramosa microbiome, we were able to analyze the functional potential of a sponge-associated microbial community in unprecedented detail. Critical functions, such as carbon fixation, which had previously only been assigned to a restricted set of sponge-associated organisms, were actually spread across diverse symbiont taxa, whereas other essential pathways, such as ammonia oxidation, were confined to specific keystone taxa.
Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation
Authors: Farhat Diana , Léon Sophie , Ghayad Sandra E. , Gadot Nicolas , Icard Philippe , Le Romancer Muriel , Hussein Nader , Lincet Hubert 
Published: January 2020

AbstractBackgroundBreast cancer is the second most common cancer in the world. Despite advances in therapies, the mechanisms of resistance remain the underlying cause of morbidity and mortality. Lipoic acid (LA) is an antioxidant and essential cofactor in oxidative metabolism. Its potential therapeutic effects have been well documented, but its mechanisms of action (MOA) are not fully understood.MethodsThe aim of this study is to validate the inhibitory LA effect on the proliferation of various breast cancer cell lines and to investigate the MOA that may be involved in this process. We tested LA effects by ex vivo studies on fresh human mammary tumour samples.ResultsWe demonstrate that LA inhibits the proliferation and Akt and ERK signalling pathways of several breast cancer cells. While searching for upstream dysregulations, we discovered the loss of expression of IGF-1R upon exposure to LA. This decrease is due to the downregulation of the convertase, furin, which is implicated in the maturation of IGF-1R. Moreover, ex vivo studies on human tumour samples showed that LA significantly decreases the expression of the proliferation marker Ki67.ConclusionLA exerts its anti-proliferative effect by inhibiting the maturation of IGF-1R via the downregulation of furin.
Synergistic anti-methicillin-resistant Staphylococcus aureus (MRSA) activity and absolute stereochemistry of 7,8-dideoxygriseorhodin C
Authors: Miller Bailey W. , Torres Joshua P. , Tun Jortan O. , Flores Malem S. , Forteza Imelda , Rosenberg Gary , Haygood Margo G. , Schmidt Eric W. , Concepcion Gisela P. 
Published: January 2020

AbstractThe emergence of antibiotic resistance necessitates not only the identification of new compounds with antimicrobial properties, but also new strategies and combination therapies to circumvent this growing problem. Here, we report synergistic activity against methicillin-resistant Staphylococcus aureus (MRSA) of the β-lactam antibiotic oxacillin combined with 7,8-dideoxygriseorhodin C in vitro. Ongoing efforts to identify antibiotics from marine mollusk-associated bacteria resulted in the isolation of 7,8-dideoxygriseorhodin C from a Streptomyces sp. strain cultivated from a marine gastropod tissue homogenate. Despite the long history of 7,8-dideoxygriseorhodin C in the literature, the absolute configuration has never been previously reported. A comparison of measured and calculated ECD spectra resolved the configuration of the spiroketal carbon C6, and 2D ROESY NMR spectroscopy established the absolute configuration as 6s,6aS. The compound is selective against Gram-positive bacteria including MRSA and Enterococcus faecium with an MIC range of 0.125–0.5 μg ml−1. Moreover, the compound synergizes with oxacillin against MRSA as observed in the antimicrobial microdilution and time-kill assays. Simultaneous treatment of the compound with oxacillin resulted in an approximately tenfold decrease in MIC with a combination index of <0.5, indicating synergistic anti-MRSA activity.
Eukaryotic transcription factors can track and control their target genes using DNA antennas
Authors: Castellanos Milagros , Mothi Nivin , Muñoz Victor 
Published: January 2020

AbstractEukaryotic transcription factors (TF) function by binding to short 6-10 bp DNA recognition sites located near their target genes, which are scattered through vast genomes. Such process surmounts enormous specificity, efficiency and celerity challenges using a molecular mechanism that remains poorly understood. Combining biophysical experiments, theory and bioinformatics, we dissect the interplay between the DNA-binding domain of Engrailed, a Drosophila TF, and the regulatory regions of its target genes. We find that Engrailed binding affinity is strongly amplified by the DNA regions flanking the recognition site, which contain long tracts of degenerate recognition-site repeats. Such DNA organization operates as an antenna that attracts TF molecules in a promiscuous exchange among myriads of intermediate affinity binding sites. The antenna ensures a local TF supply, enables gene tracking and fine control of the target site’s basal occupancy. This mechanism illuminates puzzling gene expression data and suggests novel engineering strategies to control gene expression.