bluuebunny/crossref_metadata_2025_split huggingface dataset:
PRODUCTIVITY INDICATORS OF THE DAILY STAY BED FUND IN THE RUSSIAN FEDERATION
Authors: Mel'nikov Yuriy , Bant'eva M. , Smyshlyaev A. 
Published: September 2020

The process of reducing round-the-clock bed fund with simultaneous development of hospital-replacing technologies, namely daily stay hospitals, has been going on in the Russian Federation, for more than twenty-five years, a similar trend has been observed in recent decades in most developed countries of the world.
From 2010 to 2018 provision of the population with beds of daily stay hospitals in the Russian Federation moderately increased from 15.4 per 10,000 to 17.0 (an increase of 10.7%). Hospitalization rate of the population in daily stay hospitals in the country increased from 41.9 per 1,000 population in 2010 to 56.3 in 2018 (an increase of 34.5%). At the same time, the average bed occupancy per year in daily stay hospitals for the study period decreased from 311 days to
301 days (the decrease was 3.1%). The average length of stay in daily hospitals bed decreased from 11.4 to 10.1 days (the decrease was 11.7%).
The positive dynamics of most of the studied indicators testifies to the development of the network of daily stay hospitals in the Russian Federation, the negative point is the reduction of average bed occupancy per year, what may indicate a decrease of the intensity of use of the bed fund of daily stay hospitals in the country.
Using Learning Management System to Promote Self-regulated Learning in a Flipped Classroom
Authors: Onodipe Grace , Keengwe Jared , Cottrell-Yongye Adrienne 
Published: September 2020

The inherent structure of the flipped classroom (FC) supports a learning environment that promotes students’ self-regulated learning. In this paper, we focus on how a Learning Management System (LMS), in this case BrightSpace D2L, plays a key role in supporting all aspects of the FC. We discuss how: Pre-class assignments suggest that students give their learning some forethought and planning accordingly; frequent formative assessment and feedback permits students to monitor their progress in the classroom; students control their choices for studying the resources they use; and how students have ample opportunities to reflect on their work regularly. Further, we explore how learning logs (a form of reflective writing), with the LMS journaling and Dropbox features are used to keep track of students’ journal entries as well as demonstrate how professors use the LMS to motivate and encourage students to develop self-regulated learning. Qualitative analysis of students writing are provided to reveal gains in self-regulation.
La celda sumergida: ciudad del simulacro y antípodas de la Modernidad
Authors: Silva Liévano Edilson 
Published: September 2020

Este artículo presenta un análisis sobre la novela La celda sumergida (2003) del escritor colombiano Julio Paredes, siguiendo los pasos que traza el argumento de la obra. El autor se empeña en dilucidar sobre la configuración cronotópica presente en la novela y en la condición del sujeto en ciudades del primer mundo (Nueva York) en contraste con ciudades del tercer mundo (Bogotá). Desde el punto de vista del personaje, el diálogo entre estas dos ciudades le permite demostrar cómo las dos ciudades evidencian problemas sustanciales de la Modernidad. La situación del héroe en el mundo, su individualización, la fuga sistemática para evadir el mundo exterior le permite al autor de este artículo descubrir un héroe con matices románticas,un sujeto escindido,escéptico y reflexivo frente al mundo bárbaro de la ciudad contemporánea.
El perenne enfrentamiento entre intimidad y conciencia en Rosas Artificiales de Gabriel García Márquez
Authors: Flórez Óscar 
Published: September 2020

Este documento es parte de un proyecto de investigación más amplio patrocinado por la Universidad de Canberra sobre el tema general de análisis e interpretación de historias literarias cortas. Uno de los elementos clave en la interpretación de una historia se define en la manera como el autor estructura su argumento. El acercamiento sobre cómo desarrollar el tema del cuento depende en gran medida sobre cómo el escritor estructura la acción de la historia.Esta forma es el resultado de un proceso de concentración que no permite disipación o extensión y en el cual los elementos realmente significativos se están perfeccionando. Debido a este proceso de concentración de tiempo, narrativa y ajuste, el autor logra encapsular sin retrasos o distracciones una acción simple o un acontecimiento cuyo argumento tiene bastante intensidad para ser tomado como una síntesis significativa. Debido a su longitud, un cuento implica una estructura, cuya característica esencial debe ser de forma significativa y autónoma.
Lenguaje, identidad y conflicto
Authors: Atencia Lucía 
Published: September 2020

El lenguaje es el arma más poderosa que posee el ser humano para entablar contactos de interlocución y hacerse partícipe de una sociedad, con la cual comparte, desde el código lingüístico, hasta las posibilidades de establecer, desde la cotidianidad, arquetipos, modos de vida e imaginarios con los cuales identificarse. Sin embargo, en un mundo permeado por la fuerza contundente que imprimen los medios masivos de comunicación y la reflexión posmoderna de la libertad frente a la emancipación, el lenguaje, materia prima de la comunicación, puede terminar convertido en un arma que, en lugar de ser un elemento que propenda a la identidad sostenida en el respeto por la multiculturalidad y el plurilingüismo, abra una brecha que cause una ruptura entre individuo con la comunidad en la que se integra al mismo tiempo con otros sistemas sociales.
Types of audit quality research: their advantages and disadvantages
Authors: Vaicekauskas Darius 
Published: September 2020

There is no single common definition of audit quality. Audit quality depends upon the observer, as well as on methods used in order to evaluate it. Considering that audit quality is usually an object under the investigation of three groups of stakeholders - external users, preparers and supervision authorities – three types of audit quality researches can be determined.
In accordance to laws applicable in different countries, auditors and audit firms are usually periodically inspected by professional competent inspectors. The inspectors assess whether the firms and auditors do not infringe the provisions of auditing standards, national auditing laws, as well as how they manage internal resources and policies to provide high quality auditing services. These inspections could be performed only on legal basis by legally affirmed inspectors and their findings usually reach other stakeholders only if outrage deficiencies are detected. This lead to high quality assessments costs for other stakeholders to evaluate audit quality this way.
In order to reduce quality assessment costs, external users apply audit quality surrogate researches – they employ various surrogates, which in their opinion, are closely tied with the audit quality (probability that auditors will detect deficiencies and will react properly) and assess whether these surrogates are applicable to particular audit firm. Surrogates such as audit firm size, auditor’s tenure, non-audit services provided to audit clients are often employed. Although these researches may be informative and interesting to various analytics and scientists, the lack of particular necessary information and difficult mathematical-statistical models reduce the quantity of such researches.
Due to audit clients' direct interaction with their auditors, clients do not rely on surrogates – they evaluate audit quality on their own perceptions. Usually these perceptions are based on various attributes of an audit firm (size, brand, reputation) and audit team (empathy, communication, responsiveness). That kind of research does not focus on defining audit quality, it is more leaning towards the attributes, existence of which in engagements causes clients' perceptions of audit as of good quality.
Literature analysis shows that due to increasing interest in an audit quality subject, various different types of audit quality researches will arise in the future.
Catheter-Associated Urinary Tract Infection Reduction in a Pediatric Safety Engagement Network
Authors: Foster Charles B. , Ackerman Kathy , Hupertz Vera , Mustin Laurie , Sanders Joann , Sisson Patricia , Wenthe Rachel E. 
Published: September 2020

BACKGROUND:
Catheter-associated urinary tract infections (CAUTIs) are a leading cause of health care–associated infection. Catheter insertion bundles (IBs) and maintenance bundles (MBs) have been developed to prevent CAUTIs but have not been extensively validated for use in pediatric populations. We report the CAUTI prevention efforts of a large network of children’s hospitals.

METHODS:
Children’s hospitals joined the Children’s Hospitals’ Solutions for Patient Safety engagement network from 2011 to 2017, using an open start time engagement approach, and elected to participate in CAUTI prevention efforts, with 26 submitting data initially and 128 at the end. CAUTI prevention recommendations were first released in May 2012, and IBs and MBs were released in May 2014. Hospitals reported on CAUTIs, patient-days, and urinary catheter-line days and tracked reliability to each bundle. For the network, run charts or control charts were used to plot CAUTI rates, urinary catheter use, and reliability to each bundle component.

RESULTS:
After the introduction of the pediatric CAUTI IBs and MBs, CAUTI rates across the network decreased 61.6%, from 2.55 to 0.98 infections per 1000 catheter-line days. Centerline shifts occurred both before and after the 2015 Centers for Disease Control and Prevention CAUTI definition change. Urinary catheter use rates did not decline during the intervention period. Network reliability to the IBs and MBs increased to 95.4% and 86.9%, respectively.

CONCLUSIONS:
IBs and MBs aimed at preventing CAUTIs were introduced across a large network of children’s hospitals. Across the network, the rate of urinary tract infections among hospitalized children with indwelling urinary catheters decreased 61.6%.
A de novo GABRB2 variant associated with myoclonic status epilepticus and rhythmic high‐amplitude delta with superimposed (poly) spikes (RHADS)
Authors: Nishikawa Aiko , Otani Yui , Ito Susumu , Nagata Satoru , Shiota Mutsuki , Takanashi Jun‐ichi , Nakashima Mitsuko , Saitsu Hirotomo , Matsumoto Naomichi , Oguni Hirokazu 
Published: September 2020

AbstractWe report a child who developed myoclonic status epilepticus (MSE) at four months of age, associated with rhythmic high‐amplitude delta and superimposed (poly) spikes (RHADS), harbouring a GABRB2 (β2 subunit of the GABA A receptor) variant. The patient was treated under a presumptive diagnosis of neonatal‐onset alpers syndrome (AS) and underwent targeted sequence analysis for POLG1 (polymerase gamma 1) and subsequent whole‐exome sequence analysis (WES). The patient is currently a 10‐year, eight‐month‐old boy, suffering from daily MSE associated with RHADS and severe global developmental delay from early infancy. Although POLG1 mutation was negative, WES revealed a de novo missense variant of GABRB2 (NM_021911.2: c.784G>T, p.[Val262Phe]). Based on a review of case series with GABRB2 variants, we found that five of the 18 cases shared the clinical and EEG characteristics associated with our patient. In summary, this de novo GABRB2 variant was associated with an AS phenotype, characterized by treatment‐resistant MSE and RHADS, and may represent an alternative aetiology for neonatal‐onset AS without POLG1 mutation [Published with video sequence].
Testing blood and CSF in people with epilepsy: a practical guide
Authors: Sutton Fiona , Barca Diana , Komoltsev Ilia , Craiu Dana , Guekht Alla , von Oertzen Tim , Cock Hannah R. 
Published: September 2020

AbstractLaboratory investigations, whilst not essential to the diagnosis of seizures or of epilepsy, can be fundamental to determining the cause and guiding management. Over 50% of first seizures have an acute symptomatic cause, including a range of metabolic, toxic or infectious cause. The same triggers can precipitate status epilepticus, either de novo or as part of a deterioration in control in individuals with established epilepsy. Some, such as hypoglycaemia or severe hyponatraemia, can be fatal without prompt identification and treatment. Failure to identify seizures associated with recreational drug or alcohol misuse can lead to inappropriate AED treatment, as well as a missed opportunity for more appropriate intervention. In individuals with established epilepsy on treatment, some laboratory monitoring is desirable at least occasionally, in particular, in relation to bone health, as well as in situations where changes in AED clearance or metabolism are likely (extremes of age, pregnancy, comorbid disorders of renal or hepatic function). For any clinician managing people with epilepsy, awareness of the commoner derangements associated with individual AEDs is essential to guide practice. In this article, we review indications for tests on blood, urine and/or cerebrospinal fluid in patients presenting with new‐onset seizures and status epilepticus and in people with established epilepsy presenting acutely or as part of planned monitoring. Important, but rare, neurometabolic and genetic disorders associated with epilepsy are also mentioned.
Oprawa artystyczna proklamacji królów hiszpańskich Filipa V i Ferdynanda VI w Cusco (1702, 1747)
Authors: Kubiak Ewa 
Published: September 2020

Artykuł został poświęcony uroczystościom proklamacji królewskiej Filipa V i Ferdynanda VI w Cusco (Peru), które odbyły się 8 stycznia 1702 r. i 23 września 1747 r. Rekonstrukcja świąt była możliwa dzięki trzem źródłom: kronice miasta napisanej w połowie XVIII w. przez Diego de Esquivela y Navię oraz dwóm drukom okazjonalnym zawierającym opisy uroczystości, autorstwa Pedro José de Bermúdeza (1702) i José Antonio Santandera (1748). W artykule została przeanalizowana oprawa artystyczna związana z uroczystościami, a także w pewnym zakresie odtworzono wygląd architektury okazjonalnej wraz ze zdobiącym ją malarstwem. Program ikonograficzny w czasie proklamacji Ferdynanda VI odzwierciedlał społeczny i polityczny kontekst uroczystości, która stanowiła manifestację dążeń emancypacyjnych miasta, opierających się na podkreślaniu starożytności Cusco i jego bogatej tradycji imperialnej w okresie przedhiszpańskim.
Proteome analysis of lysine 2-hydroxyisobutyrylation in the peripheral blood of systemic lupus erythematosus patients
Authors: Zhou Xianqing , Lin Hua , Zhang Ruohan , Sui Weiguo , Zhang Yue , Chen Jiejing , Xue Wen , Yan Qiang , Li Chunhong , Xu Huixuan , Huang Shaoying , Dai Werer , Tang Donge , Dai Yong 
Published: September 2020

Abstract
Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple organs, the pathogenic mechanism is related to many factors, but the specific pathogenic mechanism has not been clarified yet. Protein lysine modifications play important roles in gene regulation, transcription, metabolism and other biological processes. The lysine 2-hydroxyisobutyrylation(K hib ) histone mark has recently been discovered as a novel protein modification. In this study, patients in the active SLE group were examined (N=8), while the control group was healthy (N=20).Utilizing antibody-based affinity enrichment and nano-HPLC/MS/MS analyses of K hib peptides, we identified 156 upregulated proteins(fold change>1.5),124 downregulated proteins(fold change<1/1.5), including 220 K hib sites that were upregulated and 187 K hib sites that were downregulated. Our data demonstrate that proteins with K hib sites were localized in the cytoplasm. Functional enrichment analysis revealed that proteins with K hib sites are broadly involved in a wide range of biological processes, cellular components and molecular functions. The 03010 Ribosome pathways may exert important influence on the SLE pathogenic mechanism, according to a KEGG analysis. The functional analysis of K hib is of value for important future investigations of SLE pathogenesis.
Non-severe immunosuppression might be associated with a lower risk of moderate-severe acute respiratory distress syndrome in COVID-19.
Authors: Monreal Enric , Maza Susana Sainz de la , Gullón Pedro , Natera-Villalba Elena , Chico-García Juan Luis , Beltrán-Corbellini Álvaro , Martínez-Sanz Javier , García-Barragán Nuria , Buisán Javier , Toledano Rafael , Alonso-Canovas Araceli , Pérez-Torre Paula , Matute-Lozano María Consuelo , López-Sendón Jose Luis , García-Ribas Guillermo , Corral Íñigo , Fortún Jesús , Montero-Errasquín Beatriz , Manzano Luis , Máiz-Carro Luis , Costa-Frossard Lucienne , Masjuan Jaime 
Published: September 2020

Abstract
BACKGROUND: Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that has spread rapidly worldwide. The role of immunosuppression among COVID-19 patients has not been elucidated and management may be challenging. OBJECTIVE: To assess differences in severe outcomes of hospitalized patients with COVID-19 according to immune system state. DESIGN: Retrospective single-center observational study with confirmed COVID-19 patients admitted to Hospital Universitario Ramón y Cajal from March 18, 2020 to April 04, 2020. The final date of follow-up was April 09, 2020.PARTICIPANTS: Confirmed COVID-19 patients. MAIN MEASURES: The primary endpoint was development of moderate-severe acute respiratory distress syndrome (ARDS). Time to moderate-severe ARDS, the need for mechanical or non-invasive ventilation (MV/NIV), death, and a composite of death or MV/NIV were secondary endpoints. KEY RESULTS: Of 138 patients included, 27 (19.6%) were immunosuppressed (IS), with 95 (68.8%) male patients and a median (Q1, Q3) age of 68 (54–78) years. Among the baseline characteristics, no relevant or significant differences were observed between IS and non-immunosuppressed (non-IS) patients, detecting a non-severe immunosupression among IS. A significantly lower proportion of IS patients (22.2% [95%CI, 9.8–43.0%]) compared to non-IS patients (49.5% [95%CI, 40.2–58.9%]) developed moderate-severe ARDS, in both unadjusted (OR 0.29 [95%CI, 0.11–0.76], p=0.014) and adjusted (aOR 0.16 [95%CI, 0.05–0.55], p=0.004) analyses. After stratifying by pathologies, only IS autoimmune diseases remained significant (aOR 0.12 [95%CI, 0.03–0.57], p=0.007). Non-significant trends toward a longer time to moderate or severe ARDS, a lower need for MV/NIV, and a lower risk of death or MV/NIV were detected in IS. CONCLUSIONS: In our cohort of COVID-19 patients, non-severe immunosuppression was associated with a lower risk of moderate-severe ARDS, especially among AD. This suggests a potential protective effect from a hypothesized host hyper-inflammatory response and warrants reconsideration of management of IS patients.
Determinants of Utero-vaginal prolapse in Western Ethiopia
Authors: Firdisa Gamachis , Tilahun Temesgen , Kejela Gemechu 
Published: September 2020

Abstract
Background: Uterovaginal prolapse is a significant public health concern in developing countries like Ethiopia where access to health care is limited. It significantly affects women’s health and productivity. Thus, it is very important to identify determinant factors and take preventive actions. Methods: A hospital-based unmatched case-control study was conducted on 86 cases and 258 controls who attended gynecologic outpatient departments in Nekemte town, from May 1 to July 30/2019. Cases were women with grade II, III & IV uterovaginal prolapse while controls were women free from uterovaginal prolapse but with other gynecologic diseases. Data were collected using pretested interviewer-administered structured questionnaires and measurements on height and weight were taken to calculate the body mass index of women. Data were entered using Epi Data version 3.1 and analysis was carried out by SPSS version 24.0. Descriptive, bivariate, and multivariable logistic regressions were performed. The adjusted odds ratio with a 95% confidence interval was used and statistical significance was declared at p<0.05. Results: This study revealed, age ≥40 years (AOR=10.49; 95%CI: 4.03, 27.35), duration of labor ≥24 hours (AOR=8.32; 95%CI: 3.58, 19.33), instrumental delivery (AOR=7.40; 95%CI: 1.21, 45.28), non- utilization of family planning (AOR=3.14; 95%CI: 1.32, 7.47) and underweight (BMI <18.5 kg/m2) 5.30 (AOR=5.30; 95%CI: 1.83, 15.33) were determinants of utero vaginal prolapse. Conclusion: Age ≥ 40 years, prolonged labor, instrumental delivery, non-utilization of family planning, and underweight were identified as determinant factors of uterovaginal prolapse. Thus, family planning service utilization and appropriate and timely obstetric care are advisable.
Nrf2 protects against seawater drowning-induced acute lung injury via inhibiting ferroptosis
Authors: Qiu Yu-bao , Wan Bin-bin , Liu Gang , Wu Ya-xian , Chen Dan , Lu Mu-dan , Chen Jun-liang , Yu Ren-qiang , Chen Dao-zhen , Pang Qing-feng 
Published: September 2020

Abstract
Background: Ferroptosis is a new type of nonapoptotic cell death model that was closely related to reactive oxygen species (ROS) accumulation. Seawater drowning-induced acute lung injury (ALI) which is caused by severe oxidative stress injury, has been a major cause of accidental death worldwide. The latest evidences indicate nuclear factor (erythroid-derived 2)-like 2 (Nrf2) suppress ferroptosis and maintain cellular redox balance. Here, we test the hypothesis that activation of Nrf2 pathway attenuates seawater drowning-induced ALI via inhibiting ferroptosis.Methods: we performed studies using Nrf2-specific agonist (dimethyl fumarate), Nrf2 inhibitor (ML385), Nrf2-knockout mice and ferroptosis inhibitor (Ferrostatin-1) to investigate the potential roles of Nrf2 on seawater drowning-induced ALI and the underlying mechanisms.Results: Our data shows that Nrf2 activator dimethyl fumarate could increase cell viability, reduced the levels of intracellular ROS and lipid ROS, prevented glutathione depletion and lipid peroxide accumulation, increased FTH1 and GPX4 mRNA expression, and maintained mitochondrial membrane potential in MLE-12 cells. However, ML385 promoted cell death and lipid ROS production in MLE-12 cells. Furthermore, the lung injury became more aggravated in the Nrf2-knockout mice than that in WT mice after seawater drowning.Conclusions: These results suggested that Nrf2 can inhibit ferroptosis and therefore alleviate ALI induced by seawater drowning. The effectiveness of ferroptosis inhibition by Nrf2 provides a novel therapeutic target for seawater drowning-induced ALI.