bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parathyroidectomy is Safe in Elderly Patients: A National Surgical Quality Improvement Program Study
Authors: Khokar Amna M. , Kuchta Kristine M. , Moo‐Young Tricia A. , Winchester David J. , Prinz Richard A. 
Published: November 2019

AbstractBackgroundWith increasing age, the incidence of hyperparathyroidism is increased. This study evaluates parathyroidectomy outcomes in elderly patients.MethodsPrimary hyperparathyroidism patients having parathyroidectomy as listed in the 2005–2017 ACS‐NSQIP database were separated by age: ≤60, 61–79 and ≥80. Outcomes included complications, 30‐day mortality, return to the OR, operating times, and hospital length of stay (LOS). Multivariable logistic regression was used to compare patients 61–79 and ≥80 to those ≤60. Patients ≤60 and ≥80 were propensity score matched using gender, race, BMI, smoking status, steroid use, modified frailty index (mFI), ASA class, procedure, setting, anesthesia, and wound class. Morbidity and mortality were compared to ACS‐NSQIP database patients having elective inguinal hernia repair.ResultsOf 47,701 patients: 22,220 were ≤60, 22,683 were 61–79, and 2798 were ≥80. Patients ≥80 had more complications (2.3% vs. 1.5% for 61–79 and 1.0% for ≤60, p < 0.01), LOS > 1 day (10.3% vs. 5.8% and 6.7%, p < 0.01), and mortality (0.21% vs. 0.11% and 0.03%, p < 0.01). On multivariable analysis of the overall population, older age, male gender, steroid use, high mFI, outpatient procedure, and general anesthesia increased the risk of complications. On propensity score matched analysis, there was no difference in complications (1.5% vs. 2.2%, p = 0.06) or mortality (0.04% vs. 0.23%, p = 0.12) between patients ≤60 and ≥80. Parathyroidectomy morbidity and mortality was lower than that for elective inguinal hernia repair in patients ≥80 (2.3% vs. 10% and 0.21% vs. 1.1%, p < 0.01).ConclusionsParathyroidectomy is a safe operation, offering lower morbidity and mortality than elective hernia repair in all age groups including octogenarians.
Assessment of two different HER2 scoring systems and clinical relevance for colorectal cancer
Authors: Liu Furong , Ren Chao , Jin Ying , Xi Shaoyan , He Caiyun , Wang Fang , Wang Zixian , Xu Rui-hua , Wang Feng 
Published: November 2019

Abstract
Although the positivity of human epidermal growth factor receptor 2 (HER2) is low in colorectal cancer (CRC), anti-HER2 is becoming a new target therapy in metastatic colorectal cancer (mCRC). However, assessment of the HER2 scoring system was still not established in CRC. The purpose of our study was to evaluate HER2 status and its correlation with clinicopathological characteristics and survival according to the HER2 diagnostic criteria for gastroesophageal adenocarcinoma (GEA criteria) and the HERACLES diagnostic criteria (HERACLES criteria) in a large cohort of Chinese CRC patients. The HER2 positivity was 2.9% (43/1490) and 2.6% (39/1490) in CRCs based on the GEA criteria and the HERACLES criteria, and 3.7% (9/243) in mCRC according to both criteria. HER2 status was associated with primary tumor location (P = 0.037), regional lymph node metastasis (P = 0.035), and TNM stage (P = 0.022) in CRCs based on the HERACLES criteria. No such association was found based on the GEA criteria. Furthermore, HER2 positive only presented in patients with RAS gene wild type (P = 0.001). Significant difference was only observed between the HER2-positive and HER2-negative groups in terms of disease-free survival for stage II-III CRCs (P = 0.048) according to the HERACLES criteria, but not based on the GEA criteria. Our findings suggest that the frequency of HER2 overexpression or amplification was low in Chinese CRC patients, and provide a rationale for further evaluation of HER2 in CRC based on the HERACLES criteria and the HER2 diagnostic criteria for gastroesophageal adenocarcinoma.
Improvement of daily precipitation estimations using PRISM with inverse-distance weighting
Authors: Jeong Ha-Gyu , Ahn Joong-Bae , Lee Joonlee , Shim Kyo-Moon , Jung Myung-Pyo 
Published: November 2019

Abstract
Improved daily precipitation estimations were attempted using the parameter-elevation regressions on a parameter-elevation regression on independent slopes model (PRISM) with inverse-distance weighting (IDW) and a precipitation-masking algorithm for precipitation areas. The PRISM (PRISM_ORG) suffers two overestimation problems when the daily precipitation is estimated: overestimation of the precipitation intensity in mountainous regions and overestimation of the local precipitation areas. In order to solve the problem of overestimating the precipitation intensity, we used the IDW technique that employs the same input stations as those used in the PRISM regression (PRISM_IDW). A precipitation-masking algorithm that selectively masks the precipitation estimation grid points was additionally applied to the PRISM_IDW results (PRISM_MSK). For 6 months from March to August 2012, daily precipitation data were produced in a horizontal resolution of 1 km based on the above two experiments and PRISM_ORG. Afterwards, each experiment was evaluated for improvements. The monthly root mean squared errors (RMSEs) of PRISM_IDW and PRISM_MSK were reduced by 0.83 mm/day and 0.86 mm/day, respectively, compared to PRISM_ORG.
Perineal rectosigmoidectomy for rectal prolapse—the preferred procedure for the unfit elderly patient? 10 years experience from a UK tertiary centre
Authors: Alwahid M. , Knight S. R. , Wadhawan H. , Campbell K. L. , Ziyaie D. , Koch S. M. P. 
Published: November 2019

Abstract

Background
Rectal prolapse is a disease presentation with a prevalence of about 1%, mainly affecting older women. It usually presents with symptoms of rectal mass, rectal bleeding, fecal incontinence or constipation, with patients frequently feeling socially isolated as a result. Perineal rectosigmoidectomy is associated with lesser morbidity and mortality than the abdominal procedure, but with a much higher recurrence rate. Therefore, this technique is mainly suitable for the frail elderly patient. Specific outcomes in an elderly population have been described in only a few studies. We evaluated the morbidity, mortality, recurrence rate and functional results after this procedure related to age.

Methods
All patients who underwent a perineal rectosigmoidectomy over a 10-year period in two tertiary referral centers were included in the study. American Society of Anesthesiology (ASA) grade, pre- and postoperative symptoms, pathology-reported post-fixation specimen length, length of in-patient stay, 30-day morbidity/mortality, and recurrence were measured.

Results
A total of 45 patients underwent a perineal rectosigmoidectomy. Forty-three (95%) were female, with a median age of 82.0 years (IQR 70.5–86.5), ASA grade III and median follow-up of 20 months (range 8.5–45.5 months). Half of the cohort was over 80 years old. Significant symptomatic relief was achieved, predominantly the resolution of rectal mass (8.9% vs. 60.0% preoperatively), fecal incontinence (15.6% vs. 46.7%) and constipation (4.4% vs. 26.7%). The median length of stay was 6 days, while morbidity occurred in 14 patients (31.1%) and recurrence occurred in 6 patients (13%). There were no deaths within 30 days of the procedure and outcomes were comparable in the < 80 and ≥ 80 age group.

Conclusions
Perineal rectosigmoidectomy is safe for older patients with greater comorbidities resulting in good functional results and is associated with low morbidity and mortality.
Occupational Animal Contact in Southern and Central Vietnam
Authors:   the VIZIONS consortium, Tu Nguyen Thi Kha , Tue Ngo Tri , Vapalahti Olli , Virtala Anna-Maija K. , Van Tan Le , Rabaa Maia A. , Carrique-Mas Juan , Thwaites Guy E. , Baker Stephen 
Published: November 2019

Abstract
Despite the global zoonotic disease burden, the underlying exposures that drive zoonotic disease emergence are not understood. Here, we aimed to assess exposures to potential sources of zoonotic disease and investigate the demographics, attitudes, and behavior of individuals with sustained occupational animal contact in Vietnam. We recruited 581 animal workers (animal-raising farmers, slaughterers, animal health workers, and rat traders) and their families in southern and central Vietnam into a cohort. Cohort members were followed for 3 years and interviewed annually regarding (1) demography and attitudes regarding zoonotic disease, (2) medical history, (3) specific exposures to potential zoonotic infection sources, and (4) socioeconomic status. Interview information over the 3 years was combined and analyzed as cross-sectional data. Of the 297 cohort members interviewed, the majority (79.8%; 237/297) reported raising livestock; almost all (99.6%; 236/237) reported being routinely exposed to domestic animals, and more than a quarter (28.7%; 68/237) were exposed to exotic animals. Overall, 70% (208/297) reported slaughtering exotic animals; almost all (99.5%; 207/208) reported consuming such animals. The consumption of raw blood and meat was common (24.6%; 73/297 and 37%; 110/297, respectively). Over half (58.6%; 174/297) reported recent occupational animal-induced injuries that caused bleeding; the use of personal protective equipment (PPE) was limited. Our work demonstrates that individuals working with animals in Vietnam are exposed to a wide range of species, and there are limited procedures for reducing potential zoonotic disease exposures. We advocate better education, improved animal security, and enforced legislation of PPE for those with occupational animal exposure in Vietnam.
Performative Compliance and the State–Corporate Structuring of Neglect in a Residential Care Home for Older People
Authors: Greener Joe 
Published: November 2019

AbstractThe abuse and neglect of older people in care homes is widespread across England, but current causative explanations are limited and frequently fail to highlight the economic and political factors underpinning poor care. Informed by social harm and state–corporate crime perspectives, this study uses ethnographic data gathered through a nine-month period of working in an older person’s residential care home to show how neglect is embedded in working routines. Three aspects of care are interrogated to reveal the embedded nature of harm in the home; all reveal the rift between official, regulatory rules and informal working practices shaped by material constraints of the labor process. This article explores the role of regulatory regimes in actively legitimizing sectors, such as the residential care industry, even in the face of routine violence, by bureaucratically ensuring the appearance of compliance with formal rules. While the harms of contemporary institutionalized care for older people have its roots in material conditions, performative compliance through regulation guarantees that these injurious outcomes are concealed. This article contends that malpractice (and harm) can be explained with reference to conjoint state–corporate relationships and practices.
Natriuretic peptide system expression in murine and human submandibular salivary glands: a study of the spatial localisation of ANB, BNP, CNP and their receptors
Authors: Ahmed Araz , Gulino Alessandro , Amayo Simita , Arancio Walter , Florena Ada Maria , Belmonte Beatrice , Jurjus Abdo , Leone Angelo , Miletich Isabelle 
Published: November 2019

AbstractThe natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy murine and human submandibular salivary glands (SMGs). We show CNP is the dominant NP in mouse and human SMG and is expressed together with NP receptors in ducts, autonomic nerves and the microvasculature of the gland, suggesting CNP autocrine signalling may take place in some of these glandular structures. These data suggest the NP system may control salivary gland function during homeostasis through the regulation of electrolyte re-absorption, neural stimulation and/or blood vessel wall contraction/relaxation. We also show abnormal expression of NPRA in the stroma of a subset of human SMGs resected from patients diagnosed with oral squamous cell carcinoma (OSCC) of non-salivary gland origin. This finding warrants further research to investigate a possible correlation between early OSCC invasion and NPRA overexpression.
Iconoclasm and Imagination: Gaston Bachelard’s Philosophy of Technoscience
Authors: Zwart Hub 
Published: November 2019

AbstractGaston Bachelard (1884–1962) occupies a unique position in the history of European thinking. As a philosopher of science, he developed a profound interest in genres of the imagination, notably poetry and novels. While emphatically acknowledging the strength, precision and reliability of scientific knowledge compared to every-day experience, he saw literary phantasies as important supplementary sources of insight. Although he significantly influenced authors such as Lacan, Althusser, Foucault and others, while some of his key concepts (“epistemological rupture,” “epistemological obstacle,” “technoscience”) are still widely used, his oeuvre tends to be overlooked. And yet, as I will argue, Bachelard’s extended series of books opens up an intriguing perspective on contemporary science. First, I will point to a remarkable duality that runs through Bachelard’s oeuvre. His philosophy of science consists of two sub-oeuvres: a psychoanalysis of technoscience, complemented by a poetics of elementary imagination. I will point out how these two branches deal with complementary themes: technoscientific artefacts and literary fictions, two realms of human experience separated by an epistemological rupture. Whereas Bachelard’s work initially entails a panegyric in praise of scientific practice, he becomes increasingly intrigued by the imaginary and its basic images (“archetypes”), such as the Mother Earth archetype.
Psychotropic Medication Prescribing for Neuropsychiatric Comorbidities in Individuals Diagnosed with Autism Spectrum Disorder (ASD) in the UK
Authors: Alfageh Basmah H. , Man Kenneth K. C. , Besag Frank M. C. , Alhawassi Tariq M. , Wong Ian C. K. , Brauer Ruth 
Published: November 2019

Abstract
Autism spectrum disorder (ASD) is a lifelong disorder. In the UK, risperidone is the only psychotropic medication approved for the management of the behavioural symptoms that may accompany autism. This is a population-based study aimed to provide an evaluation of the changing trend in the incidence and prevalence of ASD and to analyse the pattern of psychotropic medication prescribing in the UK. 20,194 patients with ASD were identified. The prevalence increased 3.3-fold from 0.109 per 100 persons in 2009 to 0.355 per 100 persons in 2016. Approximately one-third of the identified cohort was prescribed at least one psychotropic medication. Although the medications approved to manage the symptoms of ASD are limited, the prescribing of such medications is increasing.
A model for roughness statistics of heterogeneous fibrous materials
Authors: Sampson William W. , Wang Di 
Published: November 2019

AbstractWe present a theory giving the standard roughness metrics $$R_{\mathrm{a}}$$Raand $$R_{\mathrm{q}}$$Rqof stochastic fibrous materials in terms of their porosity and the thickness of the constituent fibres. Our treatment shows also that $$R_{\mathrm{a}}$$Raand $$R_{\mathrm{q}}$$Rqare linearly dependent on each other with gradient depending on the skewness of the surface depth profile. Comparison of our theory with experiments on laboratory-formed paper samples and with data from the literature for industrially manufactured paper and carbon fibre nonwovens for use in fuel cells is excellent. The theory has applicability to generic families of stochastic fibrous materials and has relevance, for example, to printing of devices on paper.
Frankfurt cases and the Newcomb Problem
Authors: Ahmed Arif 
Published: November 2019

Abstract
A standard argument for one-boxing in Newcomb’s Problem is ‘Why Ain’cha Rich?’, which emphasizes that one-boxers typically make a million dollars compared to the thousand dollars that two-boxers can expect. A standard reply is the ‘opportunity defence’: the two-boxers who made a thousand never had an opportunity to make more. The paper argues that the opportunity defence is unavailable to anyone who grants that in another case—a Frankfurt case—the agent is deprived of opportunities in the way that advocates of Frankfurt cases typically claim.
Keto microbiota: A powerful contributor to host disease recovery
Authors: Cabrera-Mulero Amanda , Tinahones Alberto , Bandera Borja , Moreno-Indias Isabel , Macías-González Manuel , Tinahones Francisco J. 
Published: November 2019

AbstractGut microbiota (GM) is a key contributor to host metabolism and physiology. Data generated on comparing diseased and healthy subjects have reported changes in the GM profile between both health states, suggesting certain bacterial composition could be involved in pathogenesis. Moreover, studies reported that reshaping of GM could contribute actively to disease recovery. Interestingly, ketogenic diets (KD) have emerged recently as new economic dietotherapeutic strategy to combat a myriad of diseases (refractory epilepsy, obesity, cancer, neurodegenerative diseases…). KD, understood in a broad sense, refers to whatever dietetic approximation, which causes physiological ketosis. Therefore, high fat-low carbs diets, fasting periods or caloric restriction constitute different strategies to produce an increase of main ketones bodies, acetoacetate and β-hydroxybutyrate, in blood. Involved biological mechanisms in ketotherapeutic effects are still to be unravelled. However, it has been pointed out that GM remodelling by KD, from now on “keto microbiota”, may play a crucial role in patient response to KD treatment. In fact, germ-free animals were resistant to ketotherapeutic effects; reinforcing keto microbiota may be a powerful contributor to host disease recovery. In this review, we will comment the influence of gut microbiota on host, as well as, therapeutic potential of ketogenic diets and keto microbiota to restore health status. Current progress and limitations will be argued too. In spite of few studies have defined applicability and mechanisms of KD, in the light of results, keto microbiota might be a new useful therapeutic agent.
Heated and Salted Below Porous Convection with Generalized Temperature and Solute Boundary Conditions
Authors: Straughan Brian 
Published: November 2019

Abstract
We address the problem of initiation of convective motion in the case of a fluid saturated porous layer, containing a salt in solution, which is heated and salted below. We amplify the very interesting recent results of Nield and Kuznetsov and examine in detail a whole range of temperature and salt boundary conditions allowing for a combination of prescribed heat flux and temperature. The behaviour of the transition from stationary to oscillatory convection is examined in detail as the boundary conditions vary from prescribed temperature and salt concentration toward those of prescribed heat flux and salt flux.
Impact of MgO and K2O on Slag-Nickel Matte Equilibria
Authors: Sukhomlinov Dmitry , Virtanen Olli , Latostenmaa Petri , Jokilaakso Ari , Taskinen Pekka 
Published: November 2019

Abstract
Slag chemistry of the direct nickel matte smelting was studied in typical industrial high-grade nickel matte smelting conditions at 1400 °C and 0.1 atm pSO2. The experimental technique used involved equilibration, quenching and direct elemental phase composition analysis by Electron Probe X-ray Microanalysis. Magnesia and potassia, a typical gangue constituent of sulfidic nickel concentrates and a common impurity of industrial grade silica flux (sand), respectively, were adopted as slag modifiers in concentrations typical to industrial operations. Their effects on oxidation degree of the nickel-copper-iron matte and equilibrium concentrations of Ni and Cu in the slag were studied as a function of oxygen partial pressure. Solubility of silica in the slag increased significantly with additions of MgO and K2O in the constrained case studied, at silica saturation. Equilibrium concentrations of Ni and Cu in the slag containing MgO and K2O were about a quarter lower compared to the pure iron silicate slag, in the entire oxygen partial pressure range studied.
Classification of Simple Modules of the Ore Extension $$K[X][Y; f\frac{d}{dX}]$$
Authors: Bavula V. V. 
Published: November 2019

AbstractFor the algebras$$\Lambda $$Λin the title of the paper, a classification of simple modules is given, an explicit description of the prime and completely prime spectra is obtained, the global and the Krull dimensions of$$\Lambda $$Λare computed.
Gray Matter Changes in Parkinson’s and Alzheimer’s Disease and Relation to Cognition
Authors: Krajcovicova Lenka , Klobusiakova Patricia , Rektorova Irena 
Published: November 2019

Abstract

Purpose of Review
We summarize structural (s)MRI findings of gray matter (GM) atrophy related to cognitive impairment in Alzheimer’s disease (AD) and Parkinson’s disease (PD) in light of new analytical approaches and recent longitudinal studies results.

Recent Findings
The hippocampus-to-cortex ratio seems to be the best sMRI biomarker to discriminate between various AD subtypes, following the spatial distribution of tau pathology, and predict rate of cognitive decline. PD is clinically far more variable than AD, with heterogeneous underlying brain pathology. Novel multivariate approaches have been used to describe patterns of early subcortical and cortical changes that relate to more malignant courses of PD.

Summary
New emerging analytical approaches that combine structural MRI data with clinical and other biomarker outcomes hold promise for detecting specific GM changes in the early stages of PD and preclinical AD that may predict mild cognitive impairment and dementia conversion.
Angular dependence of nanoparticle generation in the matrix assembly cluster source
Authors: Spadaro Maria Chiara , Zhao Junlei , Terry William D. , Liu Jian , Yin Feng , Djurabekova Flyura , Palmer Richard E. 
Published: November 2019

Abstract
The matrix assembly cluster source (MACS) represents a bridge between conventional instruments for cluster beam deposition (CBD) and the level of industrial production. The method is based on Ar+ ion sputtering of a pre-condensed Ar-M matrix (where M, is typically a metal such as Ag). Each Ar+ ion produces a collision cascade and thus the formation of metal clusters is in the matrix, which are then sputtered out. Here we present an experimental and computational investigation of the cluster emission process, specifically its dependence on the Ar+ ion angle of incidence and the cluster emission angle. We find the incidence angle strongly influences the emerging cluster flux, which is assigned to the spatial location of the deposited primary ion energy relative to the cluster into the matrix. We also found an approximately constant angle between the incident ion beam and the peak in the emitted cluster distribution, with value between 99° and 109°.