bluuebunny/crossref_metadata_2025_split huggingface dataset:
German recommendations for physical activity and physical activity promotion in adults with noncommunicable diseases
Authors: Geidl Wolfgang , Abu-Omar Karim , Weege Mayra , Messing Sven , Pfeifer Klaus 
Published: February 2020

Abstract
Background
Existing physical activity guidelines predominantly focus on healthy age-stratified target groups. The objective of this study was to develop evidence-based recommendations for physical activity (PA) and PA promotion for German adults (18–65 years) with noncommunicable diseases (NCDs).

Methods
The PA recommendations were developed based on existing PA recommendations. In phase 1, systematic literature searches were conducted for current PA recommendations for seven chronic conditions (osteoarthrosis of the hip and knee, chronic obstructive pulmonary disease, stable ischemic heart disease, stroke, clinical depression, and chronic non-specific back pain). In phase 2, the PA recommendations were evaluated on the basis of 28 quality criteria, and high-quality recommendations were analysed. In phase 3, PA recommendations for seven chronic conditions were deducted and then synthesised to generate generic German PA recommendations for adults with NCDs. In relation to the recommendations for PA promotion, a systematic literature review was conducted on papers that reviewed the efficacy/effectiveness of interventions for PA promotion in adults with NCDs.

Results
The German recommendations for physical activity state that adults with NCDs should, over the course of a week, do at least 150 min of moderate-intensity aerobic PA, or 75 min of vigorous-intensity aerobic PA, or a combination of both. Furthermore, muscle-strengthening activities should be performed at least twice a week. The promotion of PA among adults with NCDs should be theory-based, specifically target PA behaviour, and be tailored to the respective target group. In this context, and as an intervention method, exercise referral schemes are one of the more promising methods of promoting PA in adults with NCDs.

Conclusion
The development of evidence-based recommendations for PA and PA promotion is an important step in terms of the initiation and implementation of actions for PA-related health promotion in Germany. The German recommendations for PA and PA promotion inform adults affected by NCDs and health professionals on how much PA would be optimal for adults with NCDs. Additionally, the recommendations provide professionals entrusted in PA promotion the best strategies and interventions to raise low PA levels in adults with NCDs. The formulation of specific PA recommendations for adults with NCDs and their combination with recommendations on PA promotion is a unique characteristic of the German recommendations.
Poor clinical outcome in metastatic melanoma is associated with a microRNA-modulated immunosuppressive tumor microenvironment
Authors: Jorge Natasha A. N. , Cruz Jéssica G. V. , Pretti Marco Antônio M. , Bonamino Martín H. , Possik Patricia A. , Boroni Mariana 
Published: February 2020

Abstract
Background
Interaction between malignant cells and immune cells that reside within the tumor microenvironment (TME) modulate different aspects of tumor development and progression. Recent works showed the importance of miRNA-containing extracellular vesicles in this crosstalk.

Methods
Interested in understanding the interplay between melanoma and immune-related TME cells, we characterized the TCGA’s metastatic melanoma samples according to their tumor microenvironment profiles, HLA-I neoepitopes, transcriptome profile and classified them into three groups. Moreover, we combined our results with melanoma single-cell gene expression and public miRNA data to better characterize the regulatory network of circulating miRNAs and their targets related to immune evasion and microenvironment response.

Results
The group associated with a worse prognosis showed phenotypic characteristics that favor immune evasion, including a strong signature of suppressor cells and less stable neoantigen:HLA-I complexes. Conversely, the group with better prognosis was marked by enrichment in lymphocyte and MHC signatures. By analyzing publicly available melanoma single-cell RNA and microvesicle microRNAs sequencing data we identified circulating microRNAs potentially involved in the crosstalk between tumor and TME cells. Candidate miRNA/target gene pairs with previously reported roles in tumor progression and immune escape mechanisms were further investigated and demonstrated to impact patient’s overall survival not only in melanoma but across different tumor types.

Conclusion
Our results underscore the impact of tumor-microenvironment interactions on disease outcomes and reveal potential non-invasive biomarkers of prognosis and treatment response.
MicroRNA 876-5p modulates EV-A71 replication through downregulation of host antiviral factors
Authors: Xu Peng , Xu Hwa , Cheng Hsu Sheng , Chan Han-Hsiang , Wang Robert Y. L. 
Published: February 2020

Abstract
Background
Human enterovirus 71 (EV-A71) is a non-enveloped virus that has a single stranded positive sense RNA genome. In a previous study, we showed that miR-876-5p upregulation was observed in the serum of patients with severe EV-A71 infection. Micro-876-5p (miR-876-5p) is a circulating miRNA that can be identified to modulate EV-A71 infections through both in vitro and in vivo studies. However, the regulatory mechanisms that involve miR-876-5p in the EV-A71 infection cycle remain unclear.

Methods
We demonstrated that miR-876-5p facilitated EV-A71 replication and expression by overexpression and knocking-down of miR-876-5p through the transfection of miR-876-5p plasmid and miR-876-5p inhibitor. Although miR-876-5p suppressed CREB5 expression, luciferase reporter assay confirmed this. We also evaluated the role of miR-876-5p in the EV-A71 infection cycle by CREB5 mediated by transfection with an anti-miR-876-5P inhibitor or in combination with an si-CREB5 plasmid.

Results
MicroR-876-5p was upregulated in EV-A71-infected neuroblastoma cells. Overexpression of miR-876-5p or knockdown of cyclic-AMP responsive element binding protein 5 (CREB5) promoted EV-A71 replication. The downregulation of miR-876-5p inhibited the accumulation of viral RNA and the production of viral proteins. Interestingly, CREB5 overexpression also suppressed EV-A71 replication. Our in vitro studies reveal that miR-876-5p directly targets CREB5. Finally, downregulation of CREB5 protein abated the inhibitory effect of anti-miR-876-5p and induced inhibitory effect of EV-A71 replication.

Conclusions
Our results suggest that intracellular miR-876-5p promotes EV-A71 replication indirectly by targeting the host CREB5 protein.
Posterior parietal cortex mediates fear renewal in a novel context
Authors: Joo Bitna , Koo Ja Wook , Lee Sukwon 
Published: February 2020

AbstractThe return of fear following extinction therapy is an important issue associated with the treatment of many fear-related disorders. Fear renewal is a suitable model, with which context-dependent modulation of the fear response can be examined. In this model, any context outside of an extinction context (e.g., novel or familiar contexts) could evoke relapse of the fear response. However, brain regions associated with context-dependent modulation are not fully understood. The posterior parietal cortex (PPC) is considered a center for integrating multisensory information and making decisions. To study its role in the contextual modulation of fear relapse, we reversibly inactivated the PPC in mice before they were exposed to various contexts after extinction training. When muscimol was infused into the PPC, fear renewal was impaired in a novel context, but not in a familiar context. Fear relapses were blocked during optogenetic inhibition of the PPC, only when animals were placed in a novel context. We propose that the neural activity of the PPC is necessary for the relapse of a precise response to an extinguished conditioned stimulus in a novel context.
The infant gut microbiome as a microbial organ influencing host well-being
Authors: Turroni Francesca , Milani Christian , Duranti Sabrina , Lugli Gabriele Andrea , Bernasconi Sergio , Margolles Abelardo , Di Pierro Francesco , van Sinderen Douwe , Ventura Marco 
Published: February 2020

AbstractInitial establishment of the human gut microbiota is generally believed to occur immediately following birth, involving key gut commensals such as bifidobacteria that are acquired from the mother. The subsequent development of this early gut microbiota is driven and modulated by specific dietary compounds present in human milk that support selective colonization. This represents a very intriguing example of host-microbe co-evolution, where both partners are believed to benefit. In recent years, various publications have focused on dissecting microbial infant gut communities and their interaction with their human host, being a determining factor in host physiology and metabolic activities. Such studies have highlighted a reduction of microbial diversity and/or an aberrant microbiota composition, sometimes referred to as dysbiosis, which may manifest itself during the early stage of life, i.e., in infants, or later stages of life. There are growing experimental data that may explain how the early human gut microbiota affects risk factors related to adult health conditions. This concept has fueled the development of various nutritional strategies, many of which are based on probiotics and/or prebiotics, to shape the infant microbiota. In this review, we will present the current state of the art regarding the infant gut microbiota and the role of key commensal microorganisms like bifidobacteria in the establishment of the first microbial communities in the human gut.
A novel technique for retrospective genetic analysis of the response to vaccination or infection using cell-free DNA from archived sheep serum and plasma
Authors: Hanks Eve , Todd Helen , Palarea-Albaladejo Javier , McNeilly Tom N. , Britton Collette , Ballingall Keith T. 
Published: February 2020

AbstractGenetic variation is associated with differences in disease resistance and susceptibility among individuals within a population. To date, molecular genetic analyses of host responses have relied on extraction of genomic DNA from whole blood or tissue samples. However, such samples are not routinely collected during large-scale field studies. We demonstrate that cell-free genomic DNA (cfDNA) may be extracted and amplified from archived plasma samples, allowing retrospective analysis of host genetic diversity. This technique was also applicable to archived serum samples up to 35 years old and to different ruminant species. As proof of concept, we used this cfDNA approach to genotype the major histocompatibility complex (MHC) class IIDRB1locus of 224 Merino sheep which had participated in field trials of a commercialHaemonchus contortusvaccine, Barbervax®, in Australia. This identified a total of 51 differentDRB1alleles and their relative frequencies. This is the first study to examine host MHC diversity using DNA extracted from archived plasma samples, an approach that may be applied to retrospective analyses of genetic diversity and responses to vaccination or infection across different species and populations.
Hypothalamic lipoma and growth hormone deficiency
Authors: Rochtus Anne , Vinckx Joseph , de Zegher Francis 
Published: February 2020

AbstractBackgroundIntracranial lipomas are rare, congenital lesions, most often located at the midline. Most hypothalamic lipomas are asymptomatic, but some cases have been associated with precocious puberty, hypothermia, headache and/or obesity.Case presentationA 7-year-old boy was referred for short stature and proved to be partially growth-hormone deficient. Magnetic resonance imaging (MRI) revealed a lipoma in the paramedian hypothalamus. Growth hormone treatment resulted in swift and uncomplicated catch-up growth.ConclusionsThe present case appears to be the first to link hypothalamic lipoma to GH deficiency. The neuro-endocrine pathophysiology underpinning this link remains to be explored.
Energy-efficient offloading decision-making for mobile edge computing in vehicular networks
Authors: Huang Xiaoge , Xu Ke , Lai Chenbin , Chen Qianbin , Zhang Jie 
Published: February 2020

AbstractDriven by the explosion transmission and computation requirement in 5G vehicular networks, mobile edge computing (MEC) attracts more attention than centralized cloud computing. The advantage of MEC is to provide a large amount of computation and storage resources to the edge of networks so as to offload computation-intensive and delay-sensitive applications from vehicle terminals. However, according to the mobility of vehicle terminals and the time varying traffic load, the optimal task offloading decisions is crucial. In this paper, we consider the uplink transmission from vehicles to road side units in the vehicular network. A dynamic task offloading decision for flexible subtasks is proposed to minimize the utility, which includes energy consumption and packet drop rate. Furthermore, a computation resource allocation scheme is introduced to allocate the computation resources of MEC server due to the differences in the computation intensity and the transmission queue of each vehicle. Consequently, a Lyapunov-based dynamic offloading decision algorithm is proposed, which combines the dynamic task offloading decision and computation resource allocation, to minimize the utility function while ensuring the stability of the queue. Finally, simulation results demonstrate that the proposed algorithm could achieve a significant improvement in the utility of vehicular networks compared with comparison algorithms.
Introduction to the special issue
Authors: Finlay Andrea , Binswanger Ingrid , Timko Christine 
Published: February 2020

AbstractThis special issue of Addiction Science & Clinical Practice, “Addiction treatment access and utilization among criminal justice involved populations”, presents a series of articles on substance use disorder treatment access and utilization by people who have contact with the criminal justice system (e.g., jails, prisons, and courts). Despite the high prevalence of substance use disorders among people who experience these settings, evidence-based treatment for substance use disorders may be unavailable and/or care may be fragmented during transitions between settings. Articles in this special issue address several gaps in the literature and present a conceptual model of opioid overdose risk, the results of a randomized controlled trial to increase treatment uptake and retention during and after incarceration, descriptions of barriers to treatment after release from incarceration, and data from nationally representative surveys of substance use disorders and treatment use among people who have been involved in the criminal justice system. Importantly, the voices of people with lived experience in the criminal justice system were incorporated in two manuscripts. Together these articles advance our understanding of how to improve care coordination and expansion of services across systems and organizations to prevent overdose, improve treatment utilization, and ultimately, improve health outcomes among criminal justice involved populations in the United States who have substance use disorders or use substances.
Anti-adipogenic effects of viscothionin in 3T3-L1 adipocytes and high fat diet induced obesity mice
Authors: Kim Sokho , Ahn Seo-Hyun , Park Jong-Heum , Park Chan Hum , Sin Yu Su , Shin Gee-Wook , Kwon Jungkee 
Published: February 2020

AbstractViscum album subsp. Coloratum, also known as Korean mistletoe, is a traditional herb that has more recently been used for the treatment of nervine, hypertensive and cardiovascular diseases. Therefore, this study was undertaken to access the anti-obesity effect of Korean mistletoe-derived polypeptide viscothionin using 3T3-L1 adipocytes in vitro and in vivo mouse experimental model. Viscothionin (up to 5 μM) was used to treat mouse 3T3-L1 pre-adipocytes during adipocyte differentiation. Adipocyte differentiation in 3T3-L1 cells was confirmed by Oil Red O staining. Obesity was induced by a high-fat diet (HFD) in C57BL/6J mice, followed by oral administration of viscothionin (up to 10 mg/kg) for 3 weeks. As a result, viscothionin (5 μM) inhibited differentiation of adipocyte cells and attenuated accumulation of intracellular lipids through activation of 5′-adenosine monophosphate-activated protein kinase (AMPK), by down-regulating phosphorylation in AKT and glycogen synthase kinase 3β (GSK3β). Treatment of viscothionin also decreased the levels of sterol regulatory element binding protein-1 (SREBP-1) and its target gene, fatty acid synthase (FAS). Moreover, viscothionin (10 mg/kg) significantly suppressed body weight and fat content, and improved serum lipid concentration, compared with the standard drug simvastatin (10 mg/kg), a well-known anti-obesity agent. The present study suggests, that viscothionin exerts anti-adipogenic effect through the activation of AMPK and has potential to prevent HFD-induced obesity.
Correction to: Dimensions within 24 weight history indices and their association with inpatient treatment outcome in adults with anorexia nervosa: analysis of routine data
Authors: Hessler Johannes Baltasar , Schlegl Sandra , Greetfeld Martin , Voderholzer Ulrich 
Published: February 2020

In the publication of this article [1], there is an error with an abbreviation.The last sentence of the results paragraph in the abstract reads as follows: “While measures of WE related more to weight gain and general ED Psychopathology, indices including lowest weight were stronger predictors of changes in slimness ideal and inappropriate compensatory behaviors.” Instead of WE (weight elevation), however, the abbreviation should say WS (weight suppression). This has now been included in this correction article.
Mobile phone app Vs bucket test as a subjective visual vertical test: A validation study
Authors: Dai Tianyang , Kurien George , Lin Vincent YW 
Published: February 2020

Background The SVV tests the ability of a person to perceive the gravitational vertical. A tilt in SVV indicates vestibular imbalance in the roll plane, and thus injuries to the utricle or its connecting nerves. A validated bedside method (et, al., 2009, 72(19):1689–1692, Neurol, Zwergal) is the bucket method, in which the subject estimates the true vertical by attempting to properly align a straight line visible on the bottom of a bucket that is rotated at random by the examiner. In our study, the subjects need to align the plumb line on the Visual Vertical iOS app to the vertical direction. Methods Measurements of the SVV were made in 22 healthy subjects (16 females and 6 males). Each subject conducted 10 iterations of bucket test and 10 iterations of iOS app test. The reliability and validity of the iOS app was analyzed by SPSS21. Results Cronbach's α for the plumb line method was 0.976, and the iOS app was 0.978. Statistical comparison of SVV values measured by the iOS app and the bucket method showed no significant difference in distribution (Mann Whitney U test U = 0.944). Conclusion The Visual Vertical iOS app is an effective and accessible substitute to the plumb line for the measurement of the validated bucket test.
Analyzing rater severity in a freshman composition course using many facet Rasch measurement
Authors: Erguvan Inan Deniz , Aksu Dunya Beyza 
Published: February 2020

AbstractThis study examined the rater severity of instructors using a multi-trait rubric in a freshman composition course offered in a private university in Kuwait. Use of standardized multi-trait rubrics is a recent development in this course and student feedback and anchor papers provided by instructors for each essay exam necessitated the assessment of rater effects, including severity/leniency and restriction of range in ratings among instructors. Data were collected from three instructors teaching the same course in Summer 2019, who rated the first midterm exam essays of their students and shared the scores with the researcher. Also, two students from each class were randomly selected and a total of six papers were marked by all instructors for anchoring purposes. Many-facet Rasch model (MFRM) was employed for data analysis. The results showed that although the raters used the rubric consistently during scoring across all examinees and tasks, they differed in their degree of leniency and severity, and tended to assign scores of 70 and 80 more frequently than the other scores. The study shows that composition instructors may differ in their rating behavior and this may cause dissatisfaction, creating a sense of unfairness among the students of severe instructors. The findings of this study are expected to help writing departments to monitor their inter-rater reliability and consistency in their ratings. The most practical way to achieve this is by organizing rater training workshops.
Seismicity induced during the development of the Rittershoffen geothermal field, France
Authors: Maurer Vincent , Gaucher Emmanuel , Grunberg Marc , Koepke Rike , Pestourie Romain , Cuenot Nicolas 
Published: February 2020

AbstractThe development of the Rittershoffen deep geothermal field (Alsace, Upper Rhine Graben) between 2012 and 2014 induced unfelt seismicity with a local magnitude of less than 1.6. This seismicity occurred during two types of operations: (1) mud losses in the Muschelkalk formation during the drilling of both wells of the doublet and (2) thermal and hydraulic stimulations of the GRT-1 well. Seismicity was also observed 4 days after the main hydraulic stimulation, although no specific operation was performed. During chemical stimulation, however, no induced seismicity was detected. In the context of all field development operations and their injection parameters (flow rates, overpressures, volumes), we detail the occurrence or lack of seismicity, its magnitude distribution and its spatial distribution. The observations suggest the presence of the rock stress memory effect (Kaiser effect) of the geothermal reservoir as well as uncritically stressed zones connected to the GRT-1 well and/or rock cohesion. A reduction of the seismic rate concurrent with an increase of injectivity was noticed as well as the reactivation of a couple of faults, including the Rittershoffen fault, which was targeted by the wells. These results are derived from the homogeneous and consistent catalogue of more than 1300 local earthquakes that is provided. This reference catalogue is based on a standard detection method, whose output was manually verified and improved. The given absolute locations have been computed in a calibrated, geologically realistic 3D velocity model. Our work builds on previous analyses addressing the seismicity induced by the GRT-1 hydraulic stimulation and places the results into a historical context, thus considering the full dynamics of the observed phenomena. This paper also complements existing descriptions of the hydrothermal characteristics of the deep reservoir by providing insights separate from the wells.