bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aktuelle Therapiekonzepte und Ergebnisse für Kinder mit
Spinaler Muskelatrophie und
Wirbelsäulendeformität
Authors: Lorenz Heiko M. , Braunschweig Lena , Hecker Marina M. , Badwan Batoul , Tsaknakis Konstantinos , Hell Anna K. 
Published: June 2020

Zusammenfassung
Hintergrund Kinder mit Spinaler Muskelatrophie (SMA) Typ I und II
entwickeln fast immer eine progrediente Wirbelsäulendeformität,
welche nach Einführung der intrathekalen Injektionstherapie mit
Nusinersen durch die damit verbundenen Schwierigkeiten bei der Punktion in den
letzten Monaten in den Fokus gerückt sind.
Ziel der Arbeit Die vorliegende Untersuchung untersucht die Ergebnisse
einer neuartigen operativen Therapie zur Wirbelsäulenkorrektur bei SMA
Kindern im Vergleich zu unbehandelten SMA Jugendlichen.
Methoden In einer prospektiven Studie wurden 30 SMA Kinder (Gruppe I) mit
von extern auszufahrenden magnetischen Implantaten versorgt, welche parallel zur
Wirbelsäule implantiert wurden. Im Wachstumsverlauf wurden die
Implantate ambulant alle drei Monate distrahiert. Diesem Kollektiv wurden 15 SMA
Jugendliche (Gruppe II) mit unbehandelten Deformitäten
gegenübergestellt.
Ergebnisse Gruppe I war bei Implantation durchschnittlich 7,6 Jahre alt
und wurde 41 Monate nachuntersucht. Der Skoliosekrümmungswinkel konnte
von 62 auf 25° (59%; p<0,001) und der Beckenschiefstand
von 15 auf 4° (73%; p<0,001) reduziert werden. Im
Gegensatz dazu hatte Gruppe II (Alter 13,7 Jahre) eine Skoliose von 101°
und einen Beckenschiefstand von 22°. In Gruppe I konnten die erzielten
Korrekturen im Untersuchungszeitraum gehalten werden.
Schlussfolgerung Bei SMA Kindern konnte durch die vorgestellte
Operationstechnik eine signifikante Skoliosereduktion und Verbesserung des
Beckenschiefstandes erreichen und im Verlauf gehalten werden im Vergleich zu
unbehandelten Jugendlichen. Gerade auch in Hinblick auf die intrathekale
Injektionstherapie mit Nusinersen zur SMA Behandlung ist die Notwendigkeit einer
Wirbelsäule ohne starke Deformierung gegeben.
Ein 15-jähriger Fußballer mit Urtikaria, Fieber, Arthritis und Myositis
Authors: Dressler Frank 
Published: June 2020

ZUSAMMENFASSUNGBerichtet wird von einem 15-Jährigen mit winterlicher Urtikaria, Fieberschüben, Arthritiden und Myositis, bei dem differenzialdiagnostisch an eine septische Arthritis, eine Kälteurtikaria und eine Autoimmunmyositis gedacht werden musste. Unter der Therapie einer systemischen juvenilen idiopathischen Arthritis mit Anakinra trat eine initiale dramatische Verschlechterung mit beginnendem akutem Nierenversagen und Kreislaufschwäche bei Makrophagenaktivierungssyndrom auf 4. Es kam unter Methylprednisolon-Pulsen unter fortgesetzter Interleukin-1-Blockade zur klinischen und paraklinischen Besserung. 18 Monate nach Beginn der Therapie konnte diese wieder beendet werden ohne bisherige Verschlechterung 5. Der Patient wird regelmäßig nachbeobachtet.
Ernährung adipöser kritisch kranker Intensivpatienten unter besonderer Beachtung der Proteindosierung
Authors: Kreymann Karl Georg 
Published: June 2020

ZusammenfassungDie Ernährung adipöser Intensivpatienten ist nach wie vor ein kontrovers diskutiertes Thema. Selbst die neuesten Leitlinien geben widersprüchliche, zum Teil auf unphysiologischen Annahmen basierende Empfehlungen. Wenn auch die meisten ein hypokalorisches Ernährungskonzept mit viel Protein befürworten, so findet sich dennoch keine Übereinstimmung, was das Ausmaß der Energiereduktion und die Proteindosierung betrifft. Wir setzen dem ein einfaches Konzept einer progressiven Hypoalimentation entgegen, das auf einer Definition des Normgewichts beruht, sowie einer Proteinzufuhr, die auf einer Schätzung der Körpermagermasse basiert. Ein Vergleich mit den herkömmlichen Vorgehensweisen belegt den physiologischeren Ansatz dieser neuen Empfehlung.
High microsatellite instability (MSI-H) is associated with distinct clinical and molecular characteristics and an improved survival in early Colon cancer (CC); real world data from the AIO molecular registry Colopredict Plus
Authors: Noepel-Duennebacke Stefanie , Juette Hendrik , Reinacher-Schick Anke , Tannapfel Andrea , Feder Inke Sabine , Kluxen Larissa , Basara Nadezda , Hiller Wolfgang , Herzog Torsten , Klaassen-Mielke Renate , Mueller Lothar , Senkal Metin , Engel Lars , Teschendorf Christian , Trenn Guido , Verdoodt Berlinda , Wolters Heiner , Uhl Waldemar 
Published: June 2020

AbstractColorectal cancer is one of the leading malignancies and still accounts for almost 25 000 deaths in Germany each year. Although there is accumulating data on the molecular basis, treatment and clinical outcome of patients within clinical trials evidence from the real-world setting is mostly lacking. We started the molecular registry trial Colopredict Plus in 2013 to collect clinical and molecular data from a real-world cohort of patients with early colon cancer stage II and III in 70 German colon cancer centers focusing on the prognostic impact of high microsatellite instability. In this interim report, we characterize a clinical cohort of 2615 patients, of whom 1787 tissue probes were analyzed. Microsatellite status was assessed using immunhistochemistry and fragment length analysis, with a concordance of 91.4 %. These established histopathological methods are sensitive and cost-effective. The median age was 72 years, significantly higher compared to clinical trial populations, with a median Charlson Comorbidity Index of 3. The stage-dependent incidence of microsatellite instability was 23.7 % and was associated with female gender, BRAF-mutation, UICC stage II and localization in the right colon. Survival calculated in disease free, relapse free and overall survival significantly differed between MSI-H and MSS, in favor of MSI-H patients. Multivariate age-adjusted analyses of relapse-free survival, disease-free survival, and overall survival highlighted microsatellite instability as a robust and positive prognostic marker for early colon cancer independent of age.
Palliativmedizin und Musiktherapie – ein Erfahrungsbericht
Authors: Walter Jana-Christin , Friesecke Iris 
Published: June 2020

ZusammenfassungDer Einsatz künstlerischer Therapien in der Palliativmedizin wird im Operationen- und Prozedurenschlüssel (OPS-Katalog), der die Grundlage für die Leistungsabrechnung der deutschen Krankenhäuser bildet, gefordert. Auf dieser Grundlage wird die Musiktherapie in palliativen Settings eingesetzt. Sowohl für die Palliativmedizin als auch die Musiktherapie gibt es zahlreiche Definitionen, und zunehmend finden sich auch Forschungsprojekte zu diesem kombinierten Thema. In dieser Veröffentlichung geht es jedoch nicht nur darum, beide Themengebiete bzw. ihre Kombination zusammenfassend strukturiert darzustellen, sondern maßgeblich darum, Ihnen als Leser bzw. Leserin einen Einblick zu ermöglichen, der vielleicht zu einer Erfahrung werden kann: eine Erfahrung, die zeigt, wie es gelingen kann, einem Patienten das Gefühl eines Sich-getragen-Wissens oder des Gut-aufgehoben-Seins zu vermitteln und dadurch zu einer verbesserten Lebensqualität beizutragen.
Zur Geschichte der Balintbewegung*
Authors: Kielhorn Rita 
Published: June 2020

ZusammenfassungBalints Wirken in Budapest, Berlin, London und im Engadin (CH) sowie die
Entwicklung der Balintbewegung werden kurz vorgestellt. Es wird gezeigt, wie
von einer eher zufälligen, freiwilligen Suche einzelner
Ärzte nach Hilfe bei der Behandlung von Patienten die Balintgruppe
zu einer anerkannten Methode im Rahmen der organisierten Fort- und
Weiterbildung für Fachärzte verschiedener Gebiete geworden
ist. Die Sensibilisierung für die Arzt-Patienten-Interaktion
über Balintgruppen und deren Wirksamkeit für das Verstehen
von Patienten aus fremden Kulturkreisen wird durch Fallbeispiele aus eigener
Praxis verdeutlicht. Die Autorin plädiert für die weiterhin
unteilbare Verantwortung des Arztes bei Diagnostik und Therapie des kranken
Menschen in seiner biopsychosozialen Einheit.
Homöopathie in der Kinderpalliativmedizin
Authors: Grasser Monika 
Published: June 2020

ZusammenfassungIn den letzten Jahren wurden viele Hilfsangebote und neue Strukturen zur Unterstützung von Palliativpatienten geschaffen. Auch in der Betreuung von schwerst und palliativ erkrankten Kindern und Jugendlichen werden viele, dem Alter der Patienten angepasste Angebote gemacht. Viele Familien suchen in diesen speziellen Situationen zusätzlich Unterstützung durch komplementäre Therapieverfahren. Hier kann die Homöopathie eine begleitende Therapie mit Hilfe der für den individuellen Patienten jeweils passenden homöopathischen Arznei anbieten, um die Krankheitssymptome des Kindes zu lindern und seine Lebensqualität zu verbessern. Die Grundzüge der Homöopathie werden dargestellt und die praktische homöopathische Betreuung und Begleitung bei 2 Kindern mit schweren angeborenen Erkrankungen wird geschildert.
Update kontagiöse Erkrankungen und internationaler Flugverkehr
Authors: Siedenburg Jörg 
Published: June 2020

ZUSAMMENFASSUNGKontagiöse Erkrankungen können durch den Luftverkehr verbreitet werden. Umgekehrt können Epidemien und Pandemien sowie die Reaktion darauf erhebliche Auswirkungen auf den Luftverkehr und seine wirtschaftlichen Grundlagen haben. Gesetzliche Regelungen auf nationaler und internationaler Basis, insbesondere die International Health Regulations (IHR), sollen die Verbreitung kontagiöser Erkrankungen über den internationalen Verkehr verhindern. Durch verschiedene Maßnahmen sollen Flugreisen von Infizierten verhindert werden. Das Übertragungsrisiko von Infektionskrankheiten an Bord ist minimal. Aus medizinischen Gründen und aufgrund der internationalen Rechtslage verbietet sich jedoch ein Lufttransport infektiöser Passagiere. Screeningverfahren sollen einen solchen verhindern. Bei Auftreten von Krankheitsfällen an Bord werden umfangreiche Maßnahmen eingeleitet, um die Ansteckung weiterer Passagiere zu verhindern. Für den Lufttransport infektiöser Patienten steht derzeit noch keine Standardlösung zur Verfügung.
“En Caul” Cesarean Delivery for Extremely Premature Fetuses: Surgical Technique and Anesthetic Options
Authors: Murakoshi Takeshi 
Published: June 2020

AbstractThe risks and technical difficulties at the cesarean delivery for extremely premature infant under 1,000g are as follows: (1) a premature infant is very weak for pressure of uterine wall or human hands, (2) skin of infant is really premature and weak, (3) uterine wall is thick and difficult to incise at lower segment of uterus, (4) classical vertical incision or reverse T-shape incision are at risk for future uterine rupture, and (5) at the timing of rupture of membrane, uterine wall may contract drastically and the infant is trapped the uterine wall, so called “hug-me-tight-uterus”.To resolve the problems, we use the technique of “En Caul” cesarean delivery with nitroglycerin. Intravenous injection of nitroglycerin just before uterine incision made the rapid and sufficient relaxation of uterine muscle. After getting adequate uterine relaxation, U- or J-shaped incision is made to lower segment of the uterus; however, we never incise the membrane before the infant was delivered. The baby is delivered with wrapped amniotic fluid and the membrane, which protect the infant against the pressure of uterine wall or surgeon’s hands. The infant is gently handled to neonatologist by “En Caul” with the placenta. Neonatologist can make the membrane ruptured and resuscitation. Own blood transfusion can be made through the umbilical cord and placenta, if the infant was anemic or hypovolemic.
Transitioning a Practice to Robotic Total Knee Arthroplasty Is Correlated with Favorable Short-Term Clinical Outcomes—A Single Surgeon Experience
Authors: King Connor A. , Jordan Mark , Bradley Alexander T. , Wlodarski Caroline , Tauchen Alexander , Puri Lalit 
Published: June 2020

Abstract
Background This study sought to evaluate the patient experience and short-term clinical outcomes associated with the hospital stay of patients who underwent robotic arm-assisted total knee arthroplasty (TKA). These results were compared with a cohort of patients who underwent TKA without robotic assistance performed by the same surgeon prior to the introduction of this technology.
Materials and Methods A cohort of consecutive patients undergoing primary TKA for the diagnosis of osteoarthritis by a single fellowship trained orthopaedic surgeon over a 39-month period was identified. Patients who underwent TKA during the year that this surgeon transitioned his entire knee arthroplasty practice to robotic assistance were excluded to eliminate selection bias and control for the learning curve. All patients received the same prosthesis and postoperative pain protocol. Patients that required intubation for failed spinal anesthetic were excluded. A final population of 492 TKAs was identified. Of these, 290 underwent TKA without robotic assistance and 202 underwent robotic arm-assisted TKA. Patient demographic characteristics and short-term clinical data were analyzed.
Results Robotic arm-assisted TKA was associated with shorter length of stay (2.3 vs. 2.6 days, p < 0.001), a 50% reduction in morphine milligram equivalent utilization (from 214 to 103, p < 0.001), and a mean increase in procedure time of 9.3 minutes (p < 0.001). There was one superficial infection in the nonrobotic cohort and there were no deep postoperative infections in either cohort. There were no manipulations under anesthesia in the robotic cohort while there were six in the nonrobotic cohort. Additionally, there were no significant differences in emergency department visits, readmissions, or return to the operating room.
Conclusion This analysis corroborates existing literature suggesting that robotic arm-assisted TKA can be correlated with improved short-term clinical outcomes. This study reports on a single surgeon's experience with regard to analgesic requirements, length of stay, pain scores, and procedure time following a complete transition to robotic arm-assisted TKA. These results underscore the importance of continued evaluation of clinical outcomes as robotic arthroplasty technology continues to grow.
Update in the Treatment of Retinopathy of Prematurity
Authors: Bancalari Aldo , Schade Ricardo 
Published: June 2020

Retinopathy of prematurity (ROP) is an alteration in the development of the immature retina vascularization that frequently occurs in premature infants and is one of the leading causes of childhood blindness worldwide. In threshold stage retinopathy, laser photocoagulation is the standard treatment, particularly in those located in zone II. However, this therapy destroys parts of the retina and can lead to significant eye complications later in life. For this reason, in the last few years, antivascular endothelial growth factor agents are being used as monotherapy or as coadjuvant with laser, especially in retinopathy located in zone I. More recently, the administration of oral propranolol has been used as prevention and/or treatment of prethreshold retinopathy with encouraging results. This review provides an overview of the current evidence on newer treatment strategies for ROP.
Key Points
Mechanical Ventilation in Pregnancy Due to COVID-19: A Cohort of Three Cases
Authors: Lucarelli Elizabeth , Behn Claudia , Lashley Susan , Smok Dorothy , Benito Carlos , Oyelese Yinka 
Published: June 2020

We describe our experience with three pregnant women with novel coronavirus disease 2019 (COVID-19) who required mechanical ventilation. Recent data suggest a mortality of 88% in nonpregnant patients with COVID-19 who require intubation and mechanical ventilation. The three women we report were intubated and mechanically ventilated during pregnancy due to respiratory failure and pneumonia resulting from COVID-19. After several days of ventilation, all three were successfully weaned off mechanical ventilation and extubated, and are continuing their pregnancies with no demonstrable adverse effects. Our experience suggests that the mortality in pregnant women with COVID-19 requiring mechanical ventilation is not necessarily as high as in nonpregnant patients with COVID-19.
Key Points
E2F1 sumoylation as a protective cellular mechanism in oxidative stress response
Authors: Graves Joshua D. , Lee Yu-Ju , Liu Kang , Li Gang , Lin Fang-Tsyr , Lin Weei-Chin 
Published: June 2020

Significance
Cells need to cope with oxidative stress caused by oxygen free radicals from mitochondrial oxidative phosphorylation. We identify a role for E2F1 to halt cell cycle progression for cell survival upon oxidative stress. Oxidative stress induces sumoylation of E2F1, primarily at lysine 266, which specifically modulates E2F1 transcriptional activity to enhance cell cycle arrest for cell survival. Furthermore, we identify SENP3 as an E2F1-interacting partner and a desumoylating enzyme for E2F1. Oxidative stress inhibits the interaction between E2F1 and SENP3, and leads to accumulation of sumoylated E2F1. These data demonstrate that sumoylation of E2F1 is important for cell cycle arrest to provide cells the opportunity to cope with oxidative stress and survive.
Split coordination in English
Authors: Taylor Ann , Pintzuk Susan 
Published: June 2020

Abstract
In this article we provide a practical demonstration of how syntactically annotated corpora (treebanks), particularly the English
Historical Parsed Corpora Series, can be used to investigate research questions with a diachronic depth and synchronic breadth
that would not otherwise be possible. The phenomenon under investigation is split coordination, in which two parts of a conjoined
constituent appear separated in the clause (e.g., and this is where my aunt lives and my
uncle
). It affects every type of coordinated constituent (subject/object DPs, predicate and attributive ADJPs,
ADVPs, PPs and DP objects of P) in Old English (OE); and it, or a superficially similar construction, occurs continuously
throughout the attested period from approximately 800 to the present day. Despite its synchronic range and diachronic persistence,
split coordination has received surprisingly little attention in the diachronic literature, with the exception of Perez Lorido’s (2009) limited study of split subjects in eight OE texts. Its modern
counterpart is most frequently analysed as Bare Argument Ellipsis (BAE). Although the OE and Present-Day English constructions
appear superficially similar, we show that not all of the OE data is amenable to a BAE analysis. We bring to bear different types
of evidence (structural, discourse/performance effects, rate of change, etc.) to argue that split coordination in fact represents
two different constructions, one of which remains stable over time while the other is lost in the post-Middle English
period.
Non-configurationality in diachrony
Authors: Ponti Edoardo Maria , Luraghi Silvia 
Published: June 2020

Abstract
Non-configurationality is a linguistic property associated with free word order, discontinuous constituents, including NPs, and
null anaphora of referential arguments. Quantitative metrics, based both on local networks (syntactic trees and word order within
sentences) and on global networks (incorporating the relations within a whole treebank into a shared graph), can reveal
correlations among these features. Using treebanks we focus on diachronic varieties of Ancient Greek and Latin, in which
non-configurationality tapered off over time, leading to the largely configurational nature of the Romance languages and of Modern
Greek. A property of global networks (density of their spectra around zero eigenvalues) measuring the regularity in word order is
shown to be strengthened from classical to late varieties. Discontinuous NPs are traced by counting the words creating
non-projectivity in dependency trees: these drop dramatically in late varieties. Finally, developments in the use of null
referential direct objects are gauged by assessing the percentage of third-person personal pronouns among verb objects. All three
features turn out to change over time due to the decay of non-configurationality. Evaluation of the strength of their pairwise
correlation shows that null direct objects and discontinuous NPs are deeply intertwined.
Spoken Latin behind written texts
Authors: Korkiakangas Timo 
Published: June 2020

Abstract
This study uses treebanking to investigate how spoken language infiltrated legal Latin in early medieval Italy. The documents used
are always formulaic, but they also always contain a ‘free’ part where the case in question is described in free prose. This paper
uses this difference to measure how ten linguistic features, representative of the evolution that took place between Classical and
Late Latin, are distributed between the formulaic and free parts. Some variants are attested equally often in both parts of the
documents, while perceptually or conceptually salient variants appear to be preserved in their conservative form mainly in the
formulaic parts.
The continuum of identities in immigrant students’ narratives in Greece
Authors: Archakis Argiris 
Published: June 2020

AbstractOur study draws on the interaction between the micro-level of individual discursive choices and the macro-level of discourses. Having at our disposal narratives by immigrant students in Greece, we highlight the continuum of identities observed. For the investigation of immigrant students’ identity construction in their narratives, we mainly employ an enriched version of Bamberg’s model (1997) on narrative analysis. This model includes the micro-levels of narrative world and narrative interaction in the context of which narrators position themselves towards the discourses of the macro-level – in our data, towards the discourse of Greek national homogenization. We distinguish among three types of identities forming a continuum from legitimization to resistance with in between hybrid stages. Our analysis shows that, despite the catalytic effect of the Greek national homogenizing discourse on the construction of immigrant students’ identities, some students find ways to resist it.
Establishment of a cell-free translation system from rice callus extracts
Authors: Suzuki Kakeru , Inoue Haruka , Matsuoka Satoshi , Tero Ryugo , Hirano-Iwata Ayumi , Tozawa Yuzuru 
Published: June 2020

Abstract
Eukaryotic in vitro translation systems require large numbers of protein and RNA components and thereby rely on the use of cell extracts. Here we established a new in vitro translation system based on rice callus extract (RCE). We confirmed that RCE maintains its initial activity even after five freeze-thaw cycles and that the optimum temperature for translation is around 20°C. We demonstrated that the RCE system allows the synthesis of hERG, a large membrane protein, in the presence of liposomes. We also showed that the introduction of a bicistronic mRNA based on 2A peptide to RCE allowed the production of two distinct proteins from a single mRNA. Our new method thus facilitates laboratory-scale production of cell extracts, making it a useful tool for the in vitro synthesis of proteins for biochemical studies.