bluuebunny/crossref_metadata_2025_split huggingface dataset:
After Initial Retrieval Practice, More Retrieval Produces Better Retention Than More Study in the Word Learning of Children With Developmental Language Disorder
Authors: Leonard Laurence B. , Deevy Patricia , Karpicke Jeffrey D. , Christ Sharon L. , Kueser Justin B. 
Published: July 2020

Purpose
Children with developmental language disorder (DLD) often have difficulty with word learning. Recent studies have shown that incorporating retrieval practice provides a significant benefit to this learning. However, we have not yet discovered the best balance between the amount of retrieval and the amount of study (hearing the word in the presence of the referent) that is provided. In this investigation, we compared a word learning procedure using more retrieval and less study with a procedure that used more study and less retrieval.

Method
Participants were 13 children with DLD and 13 same-age peers with typical language development (TD). Both groups ranged in age from 4 to 6 years. The children learned two sets of novel words, with each set taught in two sessions. During an initial criterion period, the children had the opportunity to retrieve all of the words. Following this period, the words were either retrieved without further study or studied without additional retrieval. Recall and recognition testing immediately followed the second learning session and was repeated 1 week later. Testing assessed the children's retention of both the word forms and their meanings.

Results
Better recall both immediately after learning and after 1 week was seen for the more retrieval/less study condition. This was seen for both groups of children for word form recall and for children with DLD for meaning. Group differences were not found.

Conclusion
This study served as a stringent test of the benefits of retrieval to children's word learning. Continued retrieval after initial retrieval practice appeared to be helpful even when further study was discontinued and when the comparison study condition had also provided retrieval practice in the initial stages. Further refinement of retrieval procedures might lead to the development of useful clinical tools to promote word learning.
Open Universe survey of Swift-XRT GRB fields: Flux-limited sample of HBL blazars
Authors: Giommi P. , Chang Y. L. , Turriziani S. , Glauch T. , Leto C. , Verrecchia F. , Padovani P. , Penacchioni A. V. , Arneodo F. , Barres de Almeida U. , Brandt C. H. , Capalbi M. , Civitarese O. , D’Elia V. , Di Giovanni A. , De Angelis M. , Del Rio Vera J. , Di Pippo S. , Middei R. , Perri M. , Pollock A. M. T. , Puccetti S. , Ricard N. , Ruffini R. , Sahakyan N. 
Published: July 2020

Aims. The sample of serendipitous sources detected in all Swift-XRT images pointing at gamma ray bursts (GRBs) constitutes the largest existing medium-deep survey of the X-ray sky. To build such dataset we analysed all Swift X-ray images centred on GRBs and observed over a period of 15 years using automatic tools that do not require any expertise in X-ray astronomy. Besides presenting a new large X-ray survey and a complete sample of blazars, this work aims to be a step in the direction of achieving the ultimate goal of the Open Universe Initiative, which is to enable non-expert people to benefit fully from space science data, possibly extending the potential for scientific discovery, which is currently confined within a small number of highly specialised teams, to a much larger population.
Methods. We used the Swift_deepsky Docker container encapsulated pipeline to build the largest existing flux-limited and unbiased sample of serendipitous X-ray sources. Swift_deepsky runs on any laptop or desktop computer with a modern operating system. The tool automatically downloads the data and the calibration files from the archives, runs the official Swift analysis software, and produces a number of results including images, the list of detected sources, X-ray fluxes, spectral energy distribution data, and spectral slope estimations.
Results. We used our source list to build the LogN-LogS of extra-galactic sources, which perfectly matches that estimated by other satellites. Combining our survey with multi-frequency data, we selected a complete radio-flux-density-limited sample of high energy peaked blazars (HBL). The LogN-LogS built with this data set confirms that previous samples are incomplete below ∼20 mJy.
KMT-2018-BLG-0748Lb: sub-Saturn microlensing planet orbiting an ultracool host
Authors: Han Cheongho , Shin In-Gu , Jung Youn Kil , Kim Doeon , Yee Jennifer C. , Albrow Michael D. , Chung Sun-Ju , Gould Andrew , Hwang Kyu-Ha , Lee Chung-Uk , Ryu Yoon-Hyun , Shvartzvald Yossi , Zang Weicheng , Cha Sang-Mok , Kim Dong-Jin , Kim Hyoun-Woo , Kim Seung-Lee , Lee Dong-Joo , Lee Yongseok , Park Byeong-Gon , Pogge Richard W. 
Published: July 2020

Aims. We announce the discovery of a microlensing planetary system, in which a sub-Saturn planet is orbiting an ultracool dwarf host.
Methods. We detected the planetary system by analyzing the short-timescale (tE ~ 4.4 days) lensing event KMT-2018-BLG-0748. The central part of the light curve exhibits asymmetry due to negative deviations in the rising side and positive deviations in the falling side.
Results. We find that the deviations are explained by a binary-lens model with a mass ratio between the lens components of q ~ 2 × 10−3. The short event timescale, together with the small angular Einstein radius, θE ~ 0.11 mas, indicate that the mass of the planet host is very small. The Bayesian analysis conducted under the assumption that the planet frequency is independent of the host mass indicates that the mass of the planet is Mp = 0.18−0.10+0.29 MJ, and the mass of the host, Mh = 0.087−0.047+0.138 M⊙, is near the star–brown dwarf boundary, but the estimated host mass is sensitive to this assumption about the planet hosting probability. High-resolution follow-up observations would lead to revealing the nature of the planet host.
Der Einsatz von Leih- und Zeitarbeit in der Pflege –
steigende Kosten, fehlende soziale und fachliche Akzeptanz, ausbleibende
Einarbeitung und Kurzeinweisung
Authors: Krebs Stephanie , Hasseler Martina , Lietz Anna Larina 
Published: July 2020

Zusammenfassung
Ziel der Studie Der Einsatz von Fremdpersonal in deutschen
Krankenhäusern sowie dem Bereich der Langzeitpflege wird auf
differenzierte Art und Weise diskutiert und wahrgenommen. Sowohl in politischen
Debatten als auch in Forderungen von Arbeitgeberverbänden, werden
vornehmlich betriebswirtschaftliche Argumente benannt. Doch
darüberhinausgehend ist es entscheidend, die Sichtweise der eigentlich
Betroffenen nicht zu vernachlässigen. Ziel dieser Arbeit ist es daher,
die Perspektive verschiedener Berufsgruppen aus deutschen Krankenhäusern
bezüglich des Einsatzes von Fremdpersonal aufzuzeigen.
Methodik Die beschriebenen empirischen Ergebnisse basieren auf elf
teilstrukturierten Interviews, welche nach der qualitativen Inhaltsanalyse nach
Mayring ausgewertet wurden. Die Gruppe der Befragten setzt sich aus Vertretern
der Pflege, der betrieblichen Mitarbeitendenvertretung und der
Personalverwaltung zusammen.
Ergebnisse Berufsgruppenübergreifend werden sowohl Aspekte der
betriebswirtschaftlichen als auch der sozialen und fachlichen Ebene benannt,
welche bei der Zusammenarbeit und dem Einsatz von Fremdpersonal im
stationären Bereich des deutschen Gesundheitswesens
berücksichtigt werden sollten.
Schlussfolgerung Neben den entstehenden zusätzlichen Kosten
stellen die fachliche und soziale Akzeptanz sowie eine damit verbundene
Einarbeitung des Fremdpersonals entscheidende Aspekte in der Diskussion
bezüglich des Einsatzes von Fremdpersonal dar.
Usefulness of epinephrine-added injection solution to reduce procedure time for gastric endoscopic submucosal dissection
Authors: Inoue Shuntaro , Uedo Noriya , Tabuchi Takahiro , Nakagawa Kentaro , Ohmori Masayasu , Iwagami Hiroyoshi , Matsuno Kenshi , Iwatsubo Taro , Nakahira Hiroko , Matsuura Noriko , Shichijo Satoki , Maekawa Akira , Kanesaka Takashi , Takeuchi Yoji , Higashino Koji , Ishihara Ryu 
Published: July 2020

Abstract
Background and study aims Epinephrine-added submucosal injection solution is used to facilitate hemostasis of non-variceal upper gastrointestinal bleeding and to prevent delayed bleeding of large pedunculated colorectal lesions. However, its benefit in gastric endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) is unclear. The effectiveness of epinephrine-added injection solution for outcomes of gastric ESD was examined using propensity score matching analysis.
Patients and methods A total of 1,599 patients with solitary EGC (83 with non-epinephrine-added solution and 1,516 with epinephrine-added solution) between 2011 and 2018 were enrolled. Propensity scores were calculated to balance the distribution of baseline characteristics: age, sex, tumor location, specimen size, presence of ulcer scar, tumor depth, histological tumor type, and operators’ experience, and 1:3 matching was performed. En bloc resection rate, mean procedure time, delayed bleeding rate, and perforation rate were compared between the non-epinephrine (n = 79) and epinephrine (n = 237) groups.
Results Mean procedure time was significantly shorter in the epinephrine group than in the non-epinephrine group (60 vs. 78 min, P < 0.001). No significant difference was found in the rate of en bloc resection (both 99 %), incidence of delayed bleeding (both 6 %), or perforation (0 vs. 0.8 %) between the two groups. In multiple linear regression analysis, use of epinephrine-added solution was independently associated with short procedure time (P < 0.001) after adjustment for other covariates.
Conclusion The results suggest that epinephrine-added injection solution is useful for reduction of gastric ESD procedure time, warranting validation in a randomized controlled trial.
Integrative structural, functional, and transcriptomic analyses of sex-biased brain organization in humans
Authors: Liu Siyuan , Seidlitz Jakob , Blumenthal Jonathan D. , Clasen Liv S. , Raznahan Armin 
Published: July 2020

Significance
Sex differences in brain organization are theoretically important for our understanding of sex differences in human cognition and behavior. However, neurobiological sex differences have been easier to characterize in mice than in humans. Recent murine work has revealed a highly reproducible spatial patterning of gray matter volume (GMV) sex differences that is centered on systems for socioreproductive behavior and correlated with regional expression of sex chromosome genes. We integrate neuroimaging and transcriptomic data to establish that these same characteristics also apply to GMV sex differences in humans. These findings establish conserved aspects of sex-biased brain development in humans and mice, and update our understanding of the consistency, candidate causes, and potential functional corollaries of sex-biased brain anatomy in humans.
Link-usage asymmetry and collective patterns emerging from rich-club organization of complex networks
Authors: Moretti Paolo , Hütt Marc-Thorsten 
Published: July 2020

Significance
How classical spatiotemporal patterns can be detected and studied in networks is an open question of relevance to brain dynamics, epidemic diseases, and information spreading. Our work fills this conceptual gap, highlighting how propagation patterns in networks with highly connected hubs can be identified by recording local asymmetries in excitation phenomena and predicted by quantifying local orientations with respect to the major emitter hubs. Remarkably, we find that excitations in an undirected graph may travel across a link preferentially in one direction, despite the stochastic nature of the dynamics. Our results pave the way for advances in network controllability, performance tuning, and failure prediction.
Biocement stabilization of an experimental-scale artificial slope and the reformation of iron-rich crusts
Authors: Levett Alan , Gagen Emma J. , Zhao Yitian , Vasconcelos Paulo M. , Southam Gordon 
Published: July 2020

Significance
Successful mine remediation is often the missing link in the circular and sustainable model for metal mining. Here, we provide compelling evidence that promoting the biogeochemical cycling of iron can be used to stabilize and remediate mine surfaces using crushed mine waste products. These microbially stabilized iron-rich crusts provide a surface similar to premining conditions that can be used to revegetate iron mine waste using the naturally rare plant species associated with these environments. Reformation of these iron-rich crusts will help to restore hydraulic function to degraded land sites and may provide an approach to reduce on the onset of acid mine drainage in sulphide-rich wastes.
Reproductive outcomes predicted by phase imaging with computational specificity of spermatozoon ultrastructure
Authors: Kandel Mikhail E. , Rubessa Marcello , He Yuchen R. , Schreiber Sierra , Meyers Sasha , Matter Naves Luciana , Sermersheim Molly K. , Sell G. Scott , Szewczyk Michael J. , Sobh Nahil , Wheeler Matthew B. , Popescu Gabriel 
Published: July 2020

Significance
The high incidence of human male factor infertility suggests a need for examining new ways of evaluating sperm cells. We present an approach that combines label-free imaging and artificial intelligence to obtain nondestructive markers for reproductive outcomes. Our phase-imaging system reveals nanoscale morphological details from unlabeled cells. Deep learning, on the other hand, provides a structural specificity map segmenting with high accuracy the head, midpiece, and tail. Using these binary masks applied to the quantitative phase images, we measure precisely the dry-mass content of each component. Remarkably, we found that the dry-mass ratios represent intrinsic markers with predictive power for zygote cleavage and blastocyst development.
Allosteric deactivation of PIFs and EIN3 by microproteins in light control of plant development
Authors: Wu Qingqing , Kuang Kunyan , Lyu Mohan , Zhao Yan , Li Yue , Li Jing , Pan Ying , Shi Hui , Zhong Shangwei 
Published: July 2020

Significance
How plants respond and adjust their growth to cope with environmental changes is a long-standing question in biology. By studying the initial dark-to-light transition, we reveal that a microprotein-imposed suppression of protein activity is adopted by plants to achieve rapid switch from skotomorphogenic to photomorphogenic programs. Microproteins are essential bioactive regulators in animals. A large number of microproteins are predicted in plants, but very few of them are functionally characterized. We identified two microproteins that are tissue-specifically stimulated by light and directly disrupt the oligomerization of key transcription factors in light signaling. This microprotein-directed allosteric deactivation can be utilized to develop versatile tools for posttranslational regulation of target proteins in molecular breeding.
Autonomics: In search of a foundation for next-generation autonomous systems
Authors: Harel David , Marron Assaf , Sifakis Joseph 
Published: July 2020

Significance
Autonomous systems are replacing humans in a variety of tasks, and in the years to come, such systems will become central and crucial to human life. They will include vehicles of all kinds, medical and industrial robots, agricultural and manufacturing facilities, traffic management systems, and much more. While many organizations strive to develop the next generation of trustworthy, cost-effective autonomous systems, a major gap exists between the challenges in developing these and the state of the art. There is a crucial need for a common scientific and engineering foundation for developing these systems, which we term “autonomics.” We believe that such a foundation will dramatically accelerate the deployment and acceptance of high-quality autonomous systems, for the benefit of human society.
Lipid sponge droplets as programmable synthetic organelles
Authors: Bhattacharya Ahanjit , Niederholtmeyer Henrike , Podolsky Kira A. , Bhattacharya Rupak , Song Jing-Jin , Brea Roberto J. , Tsai Chu-Hsien , Sinha Sunil K. , Devaraj Neal K. 
Published: July 2020

Significance
Organelles spatially and temporally orchestrate biochemical reactions in a cell to a degree of precision that is still unattainable in synthetic reaction systems. Additionally, organelles such as the endoplasmic reticulum (ER) contain highly interconnected and dense membrane networks that provide large reaction spaces for both transmembrane and soluble enzymes. We present lipid sponge droplets to emulate the functions of organelles such as the ER. We demonstrate that lipid sponge droplets can be programmed to internally concentrate specific proteins, to host and accelerate biochemical transformations, and to rapidly and reversibly sequester and release proteins to control enzymatic reactions. The self-assembled and programmable nature of lipid sponge droplets will facilitate the integration of complex functions for bottom-up synthetic biology.
Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA
Authors: Simonetti Francesco R. , White Jennifer A. , Tumiotto Camille , Ritter Kristen D. , Cai Mian , Gandhi Rajesh T. , Deeks Steven G. , Howell Bonnie J. , Montaner Luis J. , Blankson Joel N. , Martin Albine , Laird Gregory M. , Siliciano Robert F. , Mellors John W. , Siliciano Janet D. 
Published: July 2020

Significance
Despite clinically effective antiretroviral therapy (ART), replication-competent HIV-1 persists as latent proviral DNA capable of rekindling viral replication when ART is stopped. To cure the infection, therapies are being developed to eliminate latent HIV-1. Accurate assays for intact or rebound-competent HIV-1 are important to this effort. We previously developed the intact proviral DNA assay (IPDA) as a more accurate and scalable assay for intact HIV-1 proviruses. Here we present IPDA analysis in a diverse cohort of 400 ART-treated individuals. We confirm that intact proviruses, although vastly outnumbered by defective proviruses, are present at significantly higher frequencies than previously detected by viral outgrowth assays. We also show that IPDA amplicon signal issues, observed in 6.3% of samples, result from sequence polymorphisms.
Bidirectional titration of yeast gene expression using a pooled CRISPR guide RNA approach
Authors: Bowman Emily K. , Deaner Matthew , Cheng Jan-Fang , Evans Robert , Oberortner Ernst , Yoshikuni Yasuo , Alper Hal S. 
Published: July 2020

Significance
Traditional genetic modulation approaches are typically restricted to binary perturbations, single-sided titrations (either graded up- or down-regulation), or individual gene expression modulation. Here, we utilize a library approach that is able to simultaneously modulate gene expression in a metabolism-wide manner. This library, when coupled with next-generation sequencing, allows for the identification of gene perturbations that would have been missed by classic approaches. For the examples tested, this library identified targets that improved growth on alternative carbon sources as well as improved production of betaxanthins.
Phosphoprotein-based biomarkers as predictors for cancer therapy
Authors: Carter Angela M. , Tan Chunfeng , Pozo Karine , Telange Rahul , Molinaro Roberto , Guo Ailan , De Rosa Enrica , Martinez Jonathan O. , Zhang Shanrong , Kumar Nilesh , Takahashi Masaya , Wiederhold Thorsten , Ghayee Hans K. , Oltmann Sarah C. , Pacak Karel , Woltering Eugene A. , Hatanpaa Kimmo J. , Nwariaku Fiemu E. , Grubbs Elizabeth G. , Gill Anthony J. , Robinson Bruce , Gillardon Frank , Reddy Sushanth , Jaskula-Sztul Renata , Mobley James A. , Mukhtar M. Shahid , Tasciotti Ennio , Chen Herbert , Bibb James A. 
Published: July 2020

Significance
This study validates a path toward personalized medicine that utilizes a survey of the effective signaling state of tumors via posttranslational modification analysis as a diagnostic alternative to direct examination of genetic mutations. Here, this approach is utilized to identify biomarkers for Cdk5-driven tumors. The same approach could be adapted to identify markers of other tumor drivers. As the number of cancer types in which Cdk5 is implicated is rising and as drugs with the potential to selectively target Cdk5 are moved toward the clinic, the translational potential of this diagnostic–therapeutic coupled system will be broad.
Nanoparticles presenting clusters of CD4 expose a universal vulnerability of HIV-1 by mimicking target cells
Authors: Hoffmann Magnus A. G. , Bar-On Yotam , Yang Zhi , Gristick Harry B. , Gnanapragasam Priyanthi N. P. , Vielmetter Jost , Nussenzweig Michel C. , Bjorkman Pamela J. 
Published: July 2020

Significance
The ability of HIV-1 to rapidly develop resistance against various therapeutics remains a roadblock to finding a cure. Here we propose that nanoparticle-based therapeutics that mimic HIV-1 target cells by presenting clusters of CD4, the HIV-1 receptor, could prevent effective viral escape. We show that CD4 multimerization on the nanoparticle dramatically enhanced the neutralization potency and breadth compared with conventional CD4-based reagents that present only one or two copies of CD4. The CD4 nanoparticles neutralized a range of diverse HIV-1 strains, including patient isolates resistant to multiple broadly neutralizing antibodies. This work describes a new therapeutic direction that exploits the need of HIV-1 to bind CD4 on target cells, thus warranting further investigation for the potential development of a cure.
Incremental structure building of preverbal PPs in Dutch
Authors: Coopmans Cas W. , Schoenmakers Gert-Jan 
Published: July 2020

Abstract
Incremental comprehension of head-final constructions can reveal structural attachment preferences for ambiguous
phrases. This study investigates how temporarily ambiguous PPs are processed in Dutch verb-final constructions. In De
aannemer heeft op het dakterras bespaard/gewerkt ‘The contractor has on the roof terrace saved/worked’, the PP is
locally ambiguous between attachment as argument and as adjunct. This ambiguity is resolved by the sentence-final verb. In a
self-paced reading task, we manipulated the argument/adjunct status of the PP, and its position relative to the verb. While we
found no reading-time differences between argument and adjunct PPs, we did find that transitive verbs, for which the PP is an
argument, were read more slowly than intransitive verbs, for which the PP is an adjunct. We suggest that Dutch parsers have a
preference for adjunct attachment of preverbal PPs, and discuss our findings in terms of incremental parsing models that aim to
minimize costly reanalysis.
Morphological processing in nominalizations
Authors: Lipzig Emma van , Creemers Ava , Don Jan 
Published: July 2020

AbstractA major debate in psycholinguistics concerns the representation of morphological structure in the mental lexicon. We report the results of an auditory primed lexical decision experiment in which we tested whether verbs prime their nominalizations in Dutch. We find morphological priming effects with regular nominalizations (schorsen‘suspend’ →schorsing‘suspension’) as well as with irregular nominalizations (schieten‘shoot’ →schot‘shot’). On this basis, we claim that, despite the lack of phonological identity between stem and derivation in the case of irregular nominalizations, the morphological relation between the two forms, suffices to evoke a priming effect. However, an alternative explanation, according to which the semantic relation in combination with the phonological overlap accounts for the priming effect, cannot be excluded.