bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular Docking of Ipalbidine into Human Cyclooxygenase-2 Protein Crystal Structures
Authors: Egwolf Bernhard , Espiritu Josh David M. 
Published: June 2020

Abstract
Cyclooxygenase-2 (COX-2) is an enzyme responsible for the production of the prostaglandins, lipid molecules related to pain, inflammation, etc. Ipalbidine is a compound extracted from the crushed seeds isolated from Ipomea Alba L. (Moon Flower), which is a herbaceous vine usually found in tropical and subtropical areas in the world. The strength of the binding between a biomolecule and a ligand (drug or inhibitor) can be expressed in terms of binding affinity. When performing molecular docking, the binding affinity of a ligand bound to a receptor, in this case Ipalbidine bound to COX-2 structures, can be acquired. The seven currently available human COX-2 structures from the Protein Data Bank have been downloaded and prepared for molecular docking. Four programs have been used for the study: Autodock Tools, Autodock Vina, Visual Molecular Dynamics, and Chimera. After preparation, the binding affinities of the original bound ligands within the respective COX-2 structures were calculated. Next, the binding affinities of Ipalbidine and the seven crystal structures of COX-2 were acquired using molecular docking. The results show that Ipalbidine has a slightly lower binding affinity to the COX-2 structures compared to the original bound ligands, except for one. However, the rigid COX-2 crystal structures used in this study are optimized to accommodate the original bound ligands, not lpalbidine. In other words, the docking results for lpalbidine are expected to systematically underestimate binding affinities.
Molecular docking of modified ipalbidine ligands into human cyclooxygenase-2 protein crystal structures
Authors: Egwolf Bernhard , Gumawid Jeidrick Maxy A. 
Published: June 2020

Abstract
With many negative side-effects of nonsteroidal anti-inflammatory drugs such as gastrointestinal problems and the withdrawal of most selective COX-2 inhibitors from the market due to its increased risk of heart disease, there is a demand for an alternative analgesic (pain reliever) with less adverse side-effects. Nowadays, molecular docking is a major computational tool for drug development and drug design. This study focuses on the modification of potential analgesic ipalbidine in order to optimize its binding affinity to seven human COX-2 structures using Autodock Vina as a docking tool. Two different modified ligands were successfully enclosed in the COX-2 protein structure and were able to bind to the binding site. Based on the obtained binding affinities, it was found that by increasing the amount of hydrogen atoms on the ligand by converting the carbon double bond into a single bond, the binding affinity was reduced due to the hydrophobicity of the binding site liners. The second change was ipalbidine with inverted chirality. Inverted chirality showed higher binding affinities across the board, implying improved efficacy and bond strength. However, a change in the chirality of a drug may alter the selectivity or effect of the drug as a whole, and therefore clinical trials may be required to identify possible side-effects that may arise.
The Effect of Workplace Design on Employee Engagement, Collaborative Capability, and on Perceived Work Performance in Coworking Spaces
Authors: Paje Roma C. , Boco Lalaine B. , Gloria Joseph Christian A. , Go Hannah Angelica R. 
Published: June 2020

Abstract
Coworking spaces phenomenon is rapidly growing across the countries of North America, Europe, and Asia. Owing to its functional work environment, it offers co-workers a collaborative atmosphere that makes them more involved at work. The research study aims to describe the causal relationship of workplace design to perceived work performance through the mediating roles of employee engagement and collaborative capability with the use of Structural Equation Modeling (SEM).The total of 350 co-workers aged 18-60 years old, from 27 different co-working spaces in Metro Manila, Philippines participated in the study. The findings of this research revealed that workplace design has no direct effect on perceived work performance; however, perceived work performance improves when coworkers are more engaged and have better collaborative capability. Nonetheless, the rest of the hypothesized premises were affirmed in the result of this study. This paper can help the HR managers and the business centers to create a more flexible and constructive workplace setting for their employees. Further, the results can be used as a basis for the fundamental shift of the traditional workspace into a new creative workplace.
An assessment of the reliability and accessibility of an Airport Transit Network at the Ninoy Aquino International Airport: A case study on UBE Express
Authors: Quinito Freddie A. , Agustin Patricia Lhea S. , Alde Marieanne Korrine C. , Dela Cruz Kamila Niecel A. , Lacanlale Rachel Camille R. , Mondejar Catherine C. , Viola Aarika Karla C. 
Published: June 2020

Abstract
In the Philippines, the worsening traffic condition urged passengers arriving at the Ninoy Aquino Interna tional Airport (NAJA) to utilize taxis or transport network vehicles (TNVs) to reach their destinations despite the expensive rates. The study aimed to determine the reliability and accessibility level of UBE Express as an airport transit network. In this study, a mixed method design was used, while Likert-scale based survey questionnaires and structured interview guides were used to gather information from 100 Filipino respondent-passengers, Ai1freight 21, Inc. and inter-organizational partners respectively. The data were statistically treated using count analysis, weighted mean, and Spearman rank correlation. Based on the respondents’ assessment, UBE Express’ comfortable seats and people with disability (PWD) and senior citizen friendly features were regarded as most important components. Conversely, on-board emergency and weather information as well as different payment modes appeared to be the least important features. The study findings revealed that there was a significant relationship between reliability and accessibility. In conclusion, UBE Express is perceived to be a reliable and accessible airport transit network that can alleviate the traffic congestion in the metro.
The Factor of Availability Facilities at Home and Compulsive Internet Use among Primary School Students
Authors: Kaur Nikita , Ahmad Yasmin 
Published: June 2020

Abstract
This study was conducted with the aim to identify the relationship availability facilities at home with compulsive Internet use among primary school student in Taiping Perak. This study use quantitative method. The questionnaire were distributed to 2 primary school and involve 100 primary school student in Taiping Perak as a sample in this study. The findings of this study indicates that there is a positive relationship between the availability of facilities at home and compulsive Internet use among primary school students.
The Relationship between Socializing Activity and Compulsive Internet Use among Students in Primary School
Authors: Kaur Nikita , Ahmad Yasmin 
Published: June 2020

Abstract
This study was conducted with the aim to identify the relationship between socializing activities factor with compulsive Internet use among primary school student in Taiping Perak. This study use quantitative method. The questionnaire were distributed to 2 primary school and involve 100 primary school student in Taiping Perak as a sample in this study. The findings of this study indicates that there are high degree of positive relationship between socializing activity with compulsive Internet use.
The Development of A Mandarin Learning Mobile Application for Beginners
Authors: Xin Ang Wan , Idrus Syed Zulkarnain Syed , Ali Wan Nor Ashiqin Wan , Ishak Noormaizatul Akmar , Mustafa Wan Azani , Jamlos Mohd Aminudin , Wahab Mohd Helmy Abd 
Published: June 2020

Abstract
In the 21st century, Mandarin is spreading around globally and slowly competing with English. Many Mandarin learning applications, which focus on reading, speaking and listening, but not writing had emerged on market following the trend. Hence, there are Mandarin learners who can speak and read in Mandarin, but not in writing the words according to the correct sequence. This study is to develop a Mandarin learning application, which can increase the Mandarin proficiency of the beginners. This study helps the learners to understand the correct pronunciation and writing steps of Chinese characters. This application is effective in increasing the Mandarin proficiency of non-Mandarin speakers. Further research can be done by adding gaming elements to make the application more appealing and more interesting to use.
Prediction Medical Problem of Elderly People by Using Machine Learning Technique
Authors: Tongkaw A , Tongkaw S 
Published: June 2020

Abstract
This paper describes the machine learning technique for classification and prediction of the possibility of medical problem occur of elder people by using sklearn in Python. The research chose 16 attributes out of 23 attributes. Overall 353 samples can be classified and divided into category 0, no medical condition, 166 samples, and category 1, have medical condition, 187 samples. The root node is level of education. It can be classified with number of cigarettes per day and have exercise or not. An accuracy value after remove attribute hobby is about 67.80%, considered as good accuracy with the real data. The graph for represent the decision tree results draw by using pydotplus. This work can improve for future work by find out more parameters or other algorithm such as neural network for improving the accuracy.
Burst capacity due to corrosion acting at radial orientation of pipeline
Authors: Idris N N , Mustaffa Z , Ismil N N A 
Published: June 2020

Abstract
Carbon steel pipeline is known as the safest method to transfer a large volume of oil and gas from sources to the consumers. Carbon steel has higher tendency to fail after long time because of major hazard such as corrosion. Corrosion develops at both sides of pipeline wall; internally and externally thus the strength and integrity are affected caused by such metal deterioration. This paper emphasizes on defects interaction between external and internal walls in the radial orientation towards failure burst pressure. To date, there are no standards, codes or guidelines on radial corrosion defect to explain such behaviour. Seven types of corrosion arrangement retrieved from literature were modelled in finite element software for a pipeline in the grade API 5L X42. Von Mises distribution curve was plotted to determine the pipeline pressure limit at different corrosion arrangement. The maximum radial interaction with the lowest failure pressure was determined from the values obtained.
A New Designs of Microstrip Wi-Fi-shape Nanoantenna & Microstrip Wi-Fi-shape Slot Nanoantenna at THz region
Authors: Ali Bassam Raoof Mohammed , Alyasiri Abdulkadhum Jaafar , Ali Faris Mohammed 
Published: June 2020

Abstract
The Evolution of Terahertz technology led to focus of Scientists and Researchers on this technology field. Terahertz region lies between optics frequency range and electronics, so THz frequencies are lowest frequencies make the free space conventional optics enable still be utilized before microwave components adopt. In this paper, CST studio suite 2018 simulator is utilized to simulate and design a new Microstrip Wi-Fi-shape Nanoantenna (MWNA) & Microstrip Wi-Fi-shape Slot Nanoantenna (MWSNA). Reflection coefficient (S11), Directivity, Gain and Bandwidth are computed. The results that achieved working at Terahertz frequencies in Nano size. The Bandwidth of MWNA design and the MWSNA design working in the range of (103.3-110.3 THz) and (124.5 -127.8 THz) respectively. The Microstrip nanoantenna that utilized consist of three layers, Patch made from Gold, Substrate layer that utilized Silicon and Ground plane layer made from Gold. So the applications of these bands of THz frequencies work at visible region and near infrared (IR).
The Growth Morphology and Yield of Grey Oyster Mushrooms (Pleurotus sajor-caju) Subjected to Different Durations of Ultrasonic Sound Treatment
Authors: Ibrahim Roshita , Yie Ooi Kar , Mazidi Mazlin Nur Iman Bt. Hasnoel 
Published: June 2020

Abstract
Grey oyster mushroom (Pleurotus sajor-caju) is a type of edible mushroom that suitable to be cultivated in Malaysia. There is an increasing demand in the market due to its high nutritional values. In this study, effects of different durations of ultrasonic treatment on the growth morphology, yield enhancement and quality of mushrooms were investigated. Four different durations of ultrasonic treatment had been applied on the mushroom bags which were 1.5, 3.0, 4.5 and 6.0 minutes and 0 minutes act as control. The results showed that all ultrasonic treated bags had shorter time for mycelium to fill-up the mushroom bags as compared to control. Ultrasonic treated bags was observed could promote and activate the pinhead emergence and fruiting bodies formation. Besides, all ultrasonic treated bags also showed higher yield and better quality in terms of the largest pileus diameter of mushrooms as compared to control. For the color of mushrooms, there was no significant different (P>0.05) observed in L* values. However, treatment of 1.5 minutes had the highest a* (redness) and b* (yellowness) values. Different durations of ultrasonic treatment did not showed any significant different in texture and moisture content of mushrooms. In summary, 1.5 minutes was the best treatment duration as it took the shortest time for different growth stages with the greatest yield of mushrooms.
Comparative Evaluation of Malaysian HCM 2011 and US HCM 2010: Ramp Merging Expressway
Authors: Adnan Muhammad Akram , Rani Mohamad Saharol Nizam Abdul , Sulaiman Norliana , Zainuddin Nur Izzah , Besar Tuan Badrol Hisham Tuan 
Published: June 2020

Abstract
It is important for traffic engineers in Malaysia to comply with the relevant and appropriate standards and manuals to determine the performance of highway facilities that will provide accurate result reflecting the existing operation of highways. This paper provides the comparative study in performance evaluation of ramp segment between Malaysia Highway Capacity Manual 2011 (MHCM 2011) and US Highway Capacity Manual 2010 (USHCM 2010). The study was conducted by analyzing data collected, obtained by using Trax Apollyon Automatic Traffic Counter at Km 12, Grand Sepadu Expressway, Selangor. The evaluation of performance for ramp segment was measured by density.. Both densities measured using MHCM 2011 and USHCM 2010 were statistically compared with empirical data provided and the accuracy of both manual was calculated by using the root mean square error (RMSE) for each manual. Correspondingly,RMSE for MHCM 2011 showed lower value which was at 2.44 compared to 2.70 for USHCM 2010. Results showed that MHCM 2011 was more accurate in measuring the density for the ramp section as it has lower value.
Evaluation of Charging Profile of Lead Acid Battery used in Electrical Scooter
Authors: Ab Halim M F Mohd , Annuar K A M , Harun M H , Anuar N F , Abid M A’Azam Mohd , Zainuddin M A 
Published: June 2020

Abstract
This paper discusses about the charging profile of a lead acid battery used in electrical scooter. Lead acid battery is a robust and widely used in small electric vehicle because of its price tag. It can be considered to be one of the mature battery in the market thus the charger too. Each lead acid battery from different manufacturer possess different characteristic hence not all charger is suitable for any lead acid battery. The experiment was conducted to determine the charging profile of a 12 V cells lead acid battery connected in series to make 48V battery source. The charging current and voltage were logged and analysed for 3 charge rate. The measurement design of experiment is presented in detail as well. The experiment was repeated for at least four times. As the charging rate increase, the time taken for the charging process to complete became shorter. Nevertheless, we saw that the full battery capacity reduced at faster rate for a higher charger rate. The charging profile of the battery are also validated by the single-cell 12V battery to prove the series and parallel charging significance.
Finishing Line Evaluation of Bracket product FWD RR Spring BT 1702 by Applying 8 Steps 7 Tools Method Toyota Production (Case Study: PT BA)
Authors: Kholil Muhammad , Hanum Bethriza , Hendri  , Almahdy Indra 
Published: June 2020

Abstract
PT Bakrie Autoparts is a company which runs in foundry and mainly produces cast iron such as wheel hub, brake drum, disc rotor and flywheel. The major problem encountered by this plant is the slow delivery to consumers because the finishing process takes too long time along with the increasing demand while there is no significant improvement. This research focuses on the mapping of the hindrances and problems in the finishing line of Bracket FWD RR Spring BT 1702, how much the actual output is, what causes the problem, and what improvement can be done to remove or reduce the hindrances. The method used is 8 Step 7 Tools Toyota Production System. Time measurement result and Output Standardd calculation is based on finishing line cycle time 142 seconds per pcs and output Standardd 25 pcs per hour. After applying the method of 8 Step 7 Tools Toyota Production System, cycle time line finishing can be reduced to 66 seconds and the output Standardd to 53 pcs per hour. The output line finishing improvement reaches 112% faster than the previous one. Besides that, the improvement makes a better perfomance Standardd in the finishing process of Bracket FWD RR Spring BT 1702 so the product is in better quality and it ensures the operators’s work safety.
Teaching and Learning Based on IR 4.0: Readiness of Attitude among Polytechnics Lecturers
Authors: Lai C S , Chundra U , Lee M F 
Published: June 2020

Abstract
The Industrial Revolution 4.0 (IR 4.0) not only changed the landscape of the industry sector, but also brought significant changes to the education sector, especially for higher education. These changes include changes in pedagogy, skills, and technology related to education. However, the question arises whether the lecturers at Higher Education Institutions, such as polytechnics, are ready to apply IR 4.0 elements in their teaching process. Therefore, this study was conducted to examine the level of readiness of polytechnic lecturers towards teaching and learning process based on IR 4.0 from attitudes aspects and to study the gender differences in the measured aspect. Survey technique was used as the research design in which 222 lecturers from three polytechnics in the State of Johor were chosen as respondents for the study. A set of questionnaire was used to obtain survey data from respondents. The gathered date were analyzed by using descriptive and inferential statistics. The findings show that the readiness of lecturers in the aspect of attitudes is at a moderate level. In addition, the findings also reveal that there is a significant difference in attitude readiness between male lecturers and female lecturers. In conclusion, the responsible party should take appropriate action to improve the attitude of polytechnic lecturers so that they are better prepared to apply the IR 4.0 elements in the teaching process and subsequently produce quality graduates and meet the needs of the industry.
Effect of etching time on characterizations of porous silicon passivated by a nano-silver layer
Authors: Raypah Muna E. , Ahmed Naser M. , Samsuri S.A.M , Mahmud Shahrom 
Published: June 2020

Abstract
Porous silicon (PS) is a candidate for silicon-based optoelectronic applications. This paper presents the effect of etching time on the properties of PS deposited by a nano-thin film of a silver layer (10 nm Ag/PS) using radio frequency (RF)-sputtering technique at room temperature (RT). The PS was prepared by electrochemical etching (ECE) method for n-type (111) Si in an electrolyte solution containing hydrofluoric acid (HF) and ethanol (C2H6O) at a volume ratio of 1:4 with a direct current of 10 mA for different etching duration (30, 45, and 60 min). Structural, surface, and optical characterizations of the samples were carried out by using field emission scanning electron microscopy (FESEM), energy dispersive X-rays (EDX), X-ray diffraction (XRD), UV–Vis spectrophotometer, and photoluminescence (PL) spectroscopy. The results show that the sample prepared for 30 min demonstrated enhancement in the PL and reflectivity spectra compared to other samples which indicate a higher etching rate and a thinner wall between the pores on the surface over a larger exposed area was obtained.
Quality Improvement Using Six Sigma Method and Cost Evaluation in NFA2XSY-T 3x150 MM2 Products at PT. XYZ
Authors: Saragih Johnson , StellaSantoso  
Published: June 2020

Abstract
An electric cable is a medium that is in the form of a conductor and insulator to deliver electric current from the area of origin to the destination. The quality of a cable is very much determined by the medium of transmission, the delivery material can be copper or aluminum. PT XYZ Tbk is one of the companies engaged in the electrical cable that produces bare conductors. One type of product produced by PT XYZ Tbk is medium voltage cable.
Medium voltage cable is a type of cable that can deliver electricity to 35 kV. But among various types of medium voltage cables, NFA2XSY-T products have the highest fail rate among other types of medium voltage cable, which makes the frequency of rework and repair of these products higher. Based on historical data for three months, from June to August 2018, it is 21%, while the company’s target is 1%. Therefore, in this study a quality improvement was carried out to minimize the level of defects with the six sigma method with the Define Measure Analyze step. Improve Control.
In the Define stage, it is done by identifying the type of defect, step Measure evaluates the stability of the process and identifies the quality costs associated with defects that occur, in the Analize stage, by analyzing the causes of the dominant defect, in the Improve phase, improvements are made by making standard operating procedures, then at the control stage, it is attempted to compare between DPMO and Sigma Level before and after implementation. Based on data processing obtained DPMO of 77,585, and Sigma Level of 2.9, with total quality costs of Rp. 21,260,413 / day, after implementation DPMO was obtained at 55,556 and Sigma level of 3.9 with a total cost of Rp. 14,049,757 / day