bluuebunny/crossref_metadata_2025_split huggingface dataset:
P088 Ulcerative Colitis Related Colorectal Cancer Admissions—Insights From National Cancer Database
Authors: Seril Darren , Senatore Frank , Bhurwal Abhishek 
Published: December 2019

BACKGROUND:
Ulcerative colitis is associated with higher risk of colorectal cancer. Crude annual incidence of colorectal is estimated around 0.06-0.16%. However, there is relative paucity of colorectal cancer related admissions in Ulcerative colitis on a national level. As such, we set out to determine the proportion of CRC-related hospital admissions in Ulcerative colitis along with outcomes over the last five years.

METHODS:
This was a retrospective study utilizing the 2008-2014 National Inpatient Database Cohort for all principal discharges of Colorectal cancer in patients utilizing ICD 9 CM codes. Primary outcomes were the trends of colorectal cancer related admissions and trends in surgery related to colorectal cancer in patients with Ulcerative Colitis. Secondary outcomes were mortality, impact on healthcare utilization in terms of length of stay. These were then adjusted for confounders utilizing multivariate and Poisson regression analysis. All statistics were performed utilizing STATA software.

RESULTS:
A total of 564,372 patients were admitted to a hospital with a principal diagnosis of CRC and captured by the NIS database. Out of these, 0.25% (1,459) of these admissions were related to UC. Although the number of hospitalized CRC patients decreased from 2010 to 2014 (114,038 to 110,475; P value = 0.002), the proportion of discharges with Ulcerative colitis related CRC have not changed significantly (0.25% in 2010 to 0.29% in 2014; P > 0.05). There was a similar trend for colorectal surgeries performed during the time period (overall 0.32%). There was significant difference in CRC related admissions with UC as compared to general population. UC related CRC was noticed in younger patients (61.31 years vs 67.17 years; P < 0.001). UC related CRC admissions were more likely males (60% vs 52%; P = 0.002). There has been no significant difference in ethnicity or regional admissions. UC related CRC was less likely to be associated with liver metastasis (4.65% vs 12.6%, P < 0.001) and lung metastasis (3.4% vs 3.8%; P = 0.001). CRC related admissions with UC were more likely to undergo colorectal surgery during the admission (75% vs 60%, P < 0.001). Similarly, the mortality in UC related CRC is significantly lower as compared to general population (0.65% vs 2.34%; P < 0.001). The healthcare utilization in terms of length of stay has been similar in both the cohorts.

CONCLUSION(S):
There was a steady decrease in the number of hospitalized patients with colorectal cancer during the last several years, primarily attributable to a decrease in the older than 50 years age patients with colorectal cancer patients. This indirectly relates to the impact of colon cancer screening in the population above 50 years of age. However, UC related with CRC admissions have not witnessed the same decline over the last five years. Low frequency of liver and lung metastases indirectly indicate impact of surveillance in identifying cancer in early stage.
P089 Secukinumab Induced Ulcerative Colitis in a Patient With Psoriatic Arthritis: A Novel Approach to Refractory Cases
Authors: Sethi Vikas , Jacobs Adam , Sethi Ashwani 
Published: December 2019

INTRODUCTION:
Secukinumab is an anti-IL 17A monoclonal antibody currently used to treat psoriasis, ankylosing spondylitis, and psoriatic arthritis. It may induce inflammation in the GI tract causing exacerbation of IBD and rarely causing IBD de novo. This phenomenon itself is seldom documented with only a handful of case reports in the US and overseas. The few cases of psoriatic arthritis and Secukinumab- induced UC were managed successfully with infliximab. However, there have been no case reports managing patients refractory to TNF-alpha inhibitors. This case illustrates an alternative therapy for management of Secukinumab- induced UC who have previously failed anti-TNF treatment for psoriatic arthritis.

CASE DESCRIPTION:
A 52-year-old female with a past history of psoriatic arthritis on Secukinumab presented with one-month history of bloody diarrhea. Colonoscopy showed diffuse ulcerative colitis (UC) from hepatic flexure to rectum. Biopsies showed crypt abscesses consistent with inflammatory bowel disease (IBD) along with a positive serum p-ANCA. The patient had no prior history of ulcerative colitis with a negative screening colonoscopy 2 years ago. Stool studies were negative for infection and biopsies were negative for CMV colitis. CT Scan of Abdomen and Pelvis showed no small intestinal disease. This patient had failed prior treatment for her psoriatic arthritis with Etanercept, Leflunomide, Adalimumab and Methotrexate. Secukinumab was discontinued and the patient was started on prednisone 40 mg po daily along with mesalamine 4.8 gm po daily. She improved and was discharged home. Later, she was started on Tofacitinib 10mg po bid to treat both psoriatic arthritis and ulcerative colitis to allow prednisone taper. The patient continued to improve with resolution of the bloody diarrhea along with symptomatic and objective improvement of her psoriatic arthritis.

DISCUSSION:
There have been case reports of Ulcerative Colitis developing in patients being treated with Secukinumab for psoriatic arthritis and Ankylosing Spondylitis. During phase three clinical trials of Secukinumab, only two patients, 0.058% of the subject population, on Secukinumab developed new onset IBD. In case reports of Secukinumab induced- UC, patients were successfully treated with the monoclonal TNF-alpha antibody, infliximab. However, in this case, the patient had already failed prior therapy with a monoclonal TNF-alpha antibody, Adalimumab, and a soluble TNF decoy receptor, Etanercept. Given her resistance to multiple forms of TNF-alpha inhibition, she was started on Tofacitinib, an inhibitor of JAK1 and JAK2 kinase, approved for both psoriatic arthritis and ulcerative colitis. There are no documented case reports treating both these conditions that are refractory to other biologics. In this subset of rare patients, this case illustrates a novel approach of using Tofacitinib in achieving therapeutic response for both psoriatic arthritis and ulcerative colitis.
P106 Description of Outcomes of Inflammatory Bowel Disease Patients With Granuloma on Histology: A Single-Center Experience
Authors: Wehbe Hisham , Hosni Mohamad , Tamim Hani , Hashash Jana , Binion David 
Published: December 2019

BACKGROUND:
It has been suggested that the presence of granulomas on histologic tissue of patients with Crohn’s disease (CD) is associated with a more aggressive disease phenotype. We sought to investigate the outcomes of patients who had granulomas identified on their tissue histology.

METHODS:
This was a retrospective chart review for all inflammatory bowel disease patients who had the word ‘granuloma’ listed on their pathology report, whether from an endoscopic procedure (EGD or colonoscopy) or surgical intestinal resection specimen. We searched reports between 1997 and 2018. All patients who had a gastrointestinal granuloma were identified. Demographic, clinical, and histologic information were obtained from the medical records of these patients.

RESULTS:
A total of 41 CD patients were found to have a granuloma identified on their pathology specimen; 8 were found on a surgical resection specimen while 33 were found on endoscopic biopsies. Of the 41 patients, 53.7% were males, 41.7% were smokers, and the average age at CD diagnosis of these patients was 32 ± 15 years. The most common site for granuloma detection was the ileum accounting for 23 cases (56%). A total of 13 patients had granulomas present in more than one site/location (31.7%). The median C-reactive protein within 2 weeks of colonoscopy was 16.5 mg/L; IQR 2.9-58 (normal <2.5 mg/L), median erythrocyte sedimentation rate was 25 mm/hr; IQR 15-45 (normal 17.5 mm/hr), and median hemoglobin was 12g/dL; IQR 10.3-13.6 (normal 12.5g/dL). Of the 41 CD patients with granulomas, 42.5% were on a biologic agent, 41% on an immunomodulatory drug, and 20% had received a steroid at any time for their disease. Moreover, 24.3% had stricturing disease, 15.2% had a history of an intra-abdominal abscess, and 13.9% had a history of peri-anal disease. A total of 32.5% of granuloma CD patients had an intestinal resection and 34% had a CD related hospitalization.

CONCLUSION(S):
We suspect that granuloma patients have a more aggressive disease course. The results demonstrate that CD patients with granulomas have higher levels of inflammatory markers and lower hemoglobin. The rates of hospitalizations and need for intestinal resection approached a third of patients with granulomas.
P107 Evolution of Imaging in the Preoperative Assessment of Patients Undergoing Ileal Pouch Surgery
Authors: Wood Trevor , Zaghiyan Karen , Lightner Amy , Fleshner Phillip 
Published: December 2019

BACKGROUND:
Ileal pouch-anal anastomosis (IPAA) is the standard operative approach for ulcerative colitis (UC) or inflammatory bowel disease unclassified (IBDu) patients with medical refractory disease or dysplasia. Pouchitis or denovo Crohn’s disease are frequent adverse outcomes. The presence of small bowel (SB) mucosal inflammation before surgery might be an important predictor of these outcomes after surgery. Although small bowel follow through (SBFT) with barium has been the traditional imaging modality, cross sectional imaging using CT enterography (CTE) or MR enterography (MRE) have become increasingly utilized for preoperative SB assessment. The aim of this study was to assess changes in the utilization of SBFT versus CTE/MRE in UC and IBDu patients undergoing IPAA.

METHODS:
Prospectively generated clinical profiles on consecutive UC and IBDu patients undergoing IPAA between November 2006 and August 2019 were reviewed. Patients were classified into 2 groups: Group A (2006-2012) and Group B (2013-2019). Each patient was evaluated for preoperative SB imaging within their respective group. Baseline demographics were compared between groups. Imaging modalities included SBFT, CTE, MRE or ‘no imaging’.

RESULTS:
The study cohort of 354 patients had a mean age of 37.3 years (SD 17.1) years and included 50% males. Group A included 196 (55%) patients and Group B included 158 (45%) patients. Groups were comparable in terms of age, gender, and indication for surgery. Patients in Group A had a significantly longer disease duration (115 vs 85 months, P = 0.01) and greater number of IBDU patients (37% vs 22%, P < 0.01) versus UC patients (64% vs 77%, P < 0.01). When comparing imaging modalities, there was a significantly higher use of SBFT in Group A (44% vs 4%, P < 0.01), significantly higher use of CTE and MRE in Group B (11% vs 27%, P < 0.01 and 7% vs 40%, P < 0.01, respectively), and no difference in ‘no imaging’ between the two groups (32% vs 29%, P = 0.56).

CONCLUSION(S):
Cross sectional imaging using CTE or MRE has become the preferred modality of preoperative SB imaging in UC and IBDu patients undergoing IPAA.
P110 Using Wearable Devices to Predict Length of Stay For IBD Patients After Bowel Surgery
Authors: Yi Yangtian , Sossenheimer Philip , Rai Victoria , El Jurdi Katia , Rubin David 
Published: December 2019

BACKGROUND:
Understanding the factors that contribute to a prolonged length of stay (LOS) for IBD patients after bowel surgery is essential to improving the quality of care provided to these patients. Early ambulation and sleep are important for post-operative recovery (1,2). We used activity and sleep data collected from a wearable biosensor to predict LOS for IBD patients undergoing bowel surgery.

METHODS:
We conducted a prospective study of IBD patients undergoing bowel surgery. Patients were provided a Fitbit (Charge or Alta HR, San Francisco, CA) and asked to download and install a proprietary smart phone application (Litmus Health, Austin, TX) for collection of step and sleep data. We also collected sociodemographic and clinical data via review of all patients’ medical records. Associations were assessed using Pearson’s correlation coefficient (r).

RESULTS:
Our final sample included 22 patients (17 CD, 5 UC), 4 of whom were excluded from analysis of sleep data only. At time of surgery, mean age was 40.6 years, and the mean BMI was 27.33 kg/m2. The median LOS was 5 days (IQR, 4-6.75 days). Compliance wearing Fitbit was 81.5% for step data collection and 64.1% for sleep data collection. There was a significant increase in step count from post-operative day 1 (POD1) to POD5 (r = 0.33, P = 0.015). Between POD1 and POD5, an additional POD was associated with a 421-step increase in step count. However, Pearson’s correlation analysis failed to reveal significant associations of sleep duration and sleep efficiency with post-operative days (P > 0.05). Furthermore, mean daily steps, mean sleep duration, or mean sleep efficiency was not significantly associated with post-operative LOS (r = -0.14, P = 0.52; r = 0.22, P = 0.37; r = -0.12, P = 0.64 respectively). However, a longer sleep duration on POD5 was associated with a longer LOS (r = 0.87, P = 0.026), while a higher sleep efficiency on POD5 was associated with a shorter LOS (r = -0.88, P = 0.019). Moreover, a more positive change in sleep duration from POD4-5 was associated with a longer LOS (r = 0.95, P = 0.003), whereas a more positive change in sleep efficiency from POD4-5 was associated with a shorter LOS (r = -0.92, P = 0.011).

CONCLUSION(S):
This is the first study to characterize associations of physical activity and sleep quality with LOS for IBD patients after bowel surgery. We found a significant increase in step count from POD1 to POD5. We also demonstrated that longer sleep duration or lower sleep efficiency on POD5 was associated with a longer LOS. More positive change in sleep duration or more negative change in sleep efficiency from POD4-5 was associated with a longer LOS. We plan to conduct an interventional study to assess the effect of physical activity and sleep quality on LOS for IBD patients after bowel surgery.
Agronomic traits of dual-purpose wheat with different plant architectures under defoliation strategies
Authors: Rodolfo Giselle Regina , Souza Clovis Arruda , Stefen Deivid Luiz Vieira , Sbrissia André Fischer 
Published: December 2019

Crop-livestock system implies in the balance of appropriate animal foraging, minimizing effects on grain production on the same crop season. This study aims to assess canopy heights (20 and 30 cm) and cuts number (no cut, 1, 2 and 3 cuts) effects on wheat productivity and bromatological composition of forage, and grain yield of BRS Umbu and BRS Tarumã cultivars. Regardless cuts number and cultivars, 30 cm provided higher forage productivity (1032 and 1348 kg DM ha-1) than 20 cm (554 and 909 kg DM ha-1), for BRS Umbu and Tarumã, respectively, in average crop seasons. For both cultivars and crop seasons, mean values of 26% crude protein, 55% neutral detergent fiber and 26% acid detergent fiber were obtained. At 20 cm no difference in grain yield was observed as a function of cuts number with 3780 kg ha-1 for BRS Umbu, in average crop seasons and 4306 kg ha-1 in 2014, for BRS Tarumã. However, at 30 cm, the grain yield was penalized at least in 30% as a result only third cut. These results indicate that wheat as dual-purpose can be employed in southern Brazil in grazing systems in forage shortage times and then produce grains without yield penalties as a function to the management used.
Compatibility of Heterorhabditis amazonensis MC01 (Nematoda: rhabditida) with fertilizers and soil conditioners
Authors: Andaló Vanessa , Rocha Fernando da Silva , Faria Lucas Silva de 
Published: December 2019

Entomopathogenic nematodes are natural enemies of insect pests present in the soil; however, the intensive use of agricultural inputs can affect the action of these organisms. The objective of this study was to evaluate the effects of exposure of the nematode Heterorhabditis amazonensis MC01 to soil fertilizers containing different active ingredient, verifying their influence in the viability, infectivity and nematode production in Tenebrio molitor L. larvae. Nine products were tested, including fertilizers and soil conditioners, using the adapted IOBC/WPRS protocol. The infective juveniles were exposed to the highest concentration recommended by the manufacturer of each product for a period of 48 h. After this period, the viability, infectivity and production were evaluated and the values of mortality, infectivity reduction, production reduction and insecticide effect were obtained in order to classify the products according to IOBC criteria. In this way, the nematode H. amazonensis MC01 was compatible with most of the products under the tested conditions, so could be present in the soil at the same time. However, the product Nutriterge® Formula 3 was considered slightly harmful and Nem out® considered harmful. However, further field tests should be performed with these products to prove the deleterious effect on the nematode tested.
Utilization of Rice Husk Cellulose as a Magnetic Nanoparticle Biocomposite Fiber Source for the Absorption of Manganese (Mn2+) Ions in Peat Water
Authors: Effendi Emil Zacky , Hariady Yudhi Christian , Salaahuddin Muhammad Daffa , Irawan Chairul , Nata Iryanti Fatyasari 
Published: December 2019

Rice husk (RH) is an agricultural waste that contains cellulose. Rice husk fiber (RHF) can be used as a source of fiber in the manufacture of magnetic nanoparticle biocomposite. The purpose of this study is to synthesize and characterize magnetic nanoparticle biocomposite used as an adsorbent and evaluate its performance on the adsorption of Mn2+ ions and Total Suspended Solid (TSS) in peat water. Rice husk fiber was delignified to eliminate lignin levels. Furthermore, the biocomposite was made through the solvothermal method with and without the addition of hexanediamine. The products produced are two types of adsorbents, namely magnetic nanoparticle biocomposite with an amino group (RHB-MH) and rice husk fiber biocomposite without an amino group (RHB-M). These biocomposites were used to adsorb Mn2+ ions in peat water. Evaluations were carried out at pH 5, 6, 7, and 8 with an optimum adsorption time of 60 minutes. The solutions at the time of adsorption were evaluated to determine the optimum conditions of the adsorption process carried out. The observation of magnetic nanoparticle biocomposite based on the analysis of Scanning Electron Microscopy (SEM) shows magnetic nanoparticles formed on the surface of rice husk fiber with a diameter of 30-50 nm. X-Ray Diffraction (XRD) analysis showed that the delignification of rice husk increased Crystallinity Index (CrI) by 64.98% and reduced silica content by 78%. Fourier Transform Infra-Red (FT-IR) spectrometer show absorption peak at 570 cm-1 for Fe-O bonds and Fe3O4 peak around 1627 cm−1, indicating the presence of N-H bending. The optimum condition for Mn2+ adsorption was achieved at pH 5 and 60-minutes duration with an adsorption capacity of 54.7 mg/g and 190.78 mg/g for RHB-M and RHB-MH. The TSS reduction achieved the effectiveness of 60.2% and 90.3% for BSP-M and BSP-MH, respectively.
Antibacterial Activity and Mechanism of Action of Methanol Extract from Kasturi Mango Fruit (Mangifera casturi) on Caries-Causing Bacterium Streptococcus mutans
Authors: Suhendar Usep , Fathurrahman Muhammad , Sogandi Sogandi 
Published: December 2019

One of the problems frequently found in the oral cavity is dental caries caused by Streptococcus mutans. Thus far, dental caries is treated using antibiotics. However, the bacterium is known to be resistant to many antibiotics; hence, another alternative is needed. An alternative option is found in the Kasturi mango (Mangifera casturi). This study aims to identify the bioactive compounds of Kasturi mango and find out the mechanism of its action in inhibiting the growth of Streptococcus mutans. Kasturi mangoes were macerated using 96% methanol, then the phytochemical compounds were identified qualitatively. Antibacterial activity testing was carried out using the agar diffusion method, and bioactive compounds were identified using GCMS. The results showed that the methanol extract of Kasturi mango contains alkaloids, flavonoids, phenolics, terpenoids, and saponins. In 1 gr/mL of the methanol extract of Kasturi mango fruit has an inhibitory activity against the growth of Streptococcus mutans with a zone of inhibition of ± 10 mm and MIC (minimum inhibitory concentration) value of 25% extract. The inhibitory action is suspected to be through a mechanism where holes in the bacterial cell membrane are made. This can be seen from the results of SEM (scanning electron microscope) images showing that cell leakage or lysis has occurred. This research also, for the first time, revealed the types of bioactive compounds from the methanol extracts of Kasturi mango (Mangifera casturi) consisting of 18 compounds with the most abundance is 5-Hydroxymethylfurfural compounds, Octadecenoic acid, n-Hexadecanoic acid, Phenyl 4-methyl-1-piperidine carboxylate, and Methyl linolenate.
Use of Microwave Radiation for Activating Carbon from Rice Husk Using ZnCl2 Activator
Authors: Arnelli Arnelli , Putri Ulya Hanifah Henrika , Cholis Fandi Nasrun , Astuti Yayuk 
Published: December 2019

Activated carbon is one of the most commonly used adsorbents in a variety of separation processes because it is inexpensive, and also the design and principal of application are quite simple. The ability of activated carbon as an adsorbent is related to its large surface area and pore volume, varying pore structure, and diverse surface reactivity. The use of microwave radiation can further improve the efficiency of activated carbon adsorption. Micro-waves can affect the pore texture and surface of the activated carbon, but rarely do both practitioners and researchers control these variables influencing the relationship between features and performance of biomass-based activated carbon as an adsorbent at the time of manufacture from the initial stage (carbonation) to carbon application active (e.g., adsorption of heavy metals, surfactants, and organic molecules). This study aims to synthesize activated carbon from rice husk, which has the efficiency and capacity of adsorption of heavy metals such as Pb and activator organic molecules used is ZnCl2 30% and microwave radiation. This research has succeeded in making activated carbon using the ZnCl2 activator and microwave radiation. The time and power of microwave radiation that provides the highest efficiency in the carbon activation process for Pb ion adsorbate, were 7 minutes and 800 W. For phenol adsorbate was 5 minutes at 800 W. The highest efficiency time and concentration of adsorption for Pb ion adsorbate were 40 minutes at 60 ppm while for phenol adsorbate were 5 hours at 100 ppm. The adsorption efficiency for Pb cation adsorbate was 99.57%. While for phenol adsorbate is 81.05%. Characterization with FTIR, SEM-EDX, and SAA showed a C-Cl bond, the pores were visible, and an increased surface area of activated carbon was 36.9 times the surface area of carbon and the pores formed were mesoporous.
Aufwand und Komplexität der Trendbeobachtung
Authors: Georgy Ursula 
Published: December 2019

Abstract
Für Bibliotheken wird es immer relevanter, sich auch technischen Trends zuzuwenden, da sie in den meisten Fällen die Basis für neue Dienstleistungen sind. Es gibt eine Reihe von Quellen, um Trends zu ermitteln, doch erfordert Trendbeobachtung auch die inhaltliche Erschließung der (technischen) Inhalte / Details. Für Bibliotheken stellt dies in den meisten Fällen eine große Herausforderung dar. Der Beitrag zeigt erste Ansätze für eine mögliche Vorgehensweise auf und nennt auch den zeitlichen Aufwand.