bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modifiable risk factors related to burnout levels in the medical workplace in Taiwan: cross-sectional study
Authors: Lin Yu-Li , Chen Cing-Hua , Chu Wei-Min , Hu Sung-Yuan , Liou Yi-Sheng , Yang Yi-Chien , Tsan Yu-Tse 
Published: November 2019

ObjectivesTo detect the combined effects of lifestyle factors on work-related burnout (WB) and to analyse the impact of the number of weekend catch-up sleep hours on burnout risk in a medical workplace.DesignCross-sectional study.SettingHospital-based survey in Taiwan.ParticipantsIn total, 2746 participants completed the hospital’s Overload Health Control System questionnaire for the period from the first day of January 2016 to the end of December 2016, with a response rate of 70.5%. The voluntary participants included 358 physicians, 1406 nurses, 367 medical technicians and 615 administrative staff.Primary and secondary outcome measuresAll factors that correlated significantly with WB were entered into a multinomial logistic regression after adjustment for other factors. The dose–response relationship of combined lifestyle factors and catch-up sleep hours associated with WB was explored by logistic regression.ResultsAbnormal meal time (adjusted OR 2.41, 95% CI 1.85 to 3.15), frequently eating out (adjusted OR 1.49, 95% CI 1.12 to 1.97), lack of sleep (adjusted OR 5.13, 95% CI 3.94 to 6.69), no exercise (adjusted OR 1.41, 95% CI 1.10 to 1.81) and >40 work hours (adjusted OR 2.72, 95% CI 2.08–3.57) were independently associated with WB (for high level compared with low level). As the number of risk factors increased (1–5), so did the proportion of high severity of WB (adjusted OR 1.39, 95% CI 0.45 to 4.27, to adjusted OR 32.98, 95% CI 10.78 to 100.87). For those with more than 7 hours’ sleep on workdays, weekend catch-up sleep (≤0/>0 and ≤2/>2 hours) was found to be related to an increase of burnout risk (adjusted OR 4.91, 95% CI 2.24 to 10.75/adjusted OR 4.94, 95% CI 2.54 to 9.63/adjusted OR 6.74, 95% CI 2.94 to 15.46).ConclusionWB in the medical workplace was affected by five unhealthy lifestyle factors, and combinations of these factors were associated with greater severity of WB. Weekend catch-up sleep was correlated with lower burnout risk in those with a short workday sleep duration (less than 7 hours). Clinicians should pay particular attention to medical staff with short sleep duration without weekend catch-up sleep.
Improving the geographical precision of rural chronic disease surveillance by using emergency claims data: a cross-sectional comparison of survey versus claims data in Sullivan County, New York
Authors: Lee David C , Feldman Justin M , Osorio Marcela , Koziatek Christian A , Nguyen Michael V , Nagappan Ashwini , Shim Christopher J , Vinson Andrew J , Thorpe Lorna E , McGraw Nancy A 
Published: November 2019

ObjectivesSome of the most pressing health problems are found in rural America. However, the surveillance needed to track and prevent disease in these regions is lacking. Our objective was to perform a comprehensive health survey of a single rural county to assess the validity of using emergency claims data to estimate rural disease prevalence at a sub-county level.DesignWe performed a cross-sectional study of chronic disease prevalence estimates using emergency department (ED) claims data versus mailed health surveys designed to capture a substantial proportion of residents in New York’s rural Sullivan County.SettingSullivan County, a rural county ranked second-to-last for health outcomes in New York State.ParticipantsAdult residents of Sullivan County aged 25 years and older who responded to the health survey in 2017–2018 or had at least one ED visit in 2011–2015.Outcome measuresWe compared age and gender-adjusted prevalence of hypertension, hyperlipidaemia, diabetes, cancer, asthma and chronic obstructive pulmonary disease/emphysema among nine sub-county areas.ResultsOur county-wide mailed survey obtained 6675 completed responses for a response rate of 30.4%. This sample represented more than 12% of the estimated 53 020 adults in Sullivan County. Using emergency claims data, we identified 34 576 adults from Sullivan County who visited an ED at least once during 2011–2015. At a sub-county level, prevalence estimates from mailed surveys and emergency claims data correlated especially well for diabetes (r=0.90) and asthma (r=0.85). Other conditions were not well correlated (range: 0.23–0.46). Using emergency claims data, we created more geographically detailed maps of disease prevalence using geocoded addresses.ConclusionsFor select conditions, emergency claims data may be useful for tracking disease prevalence in rural areas and providing more geographically detailed estimates. For rural regions lacking robust health surveillance, emergency claims data can inform how to geographically target efforts to prevent chronic disease.
Effects of e-aid cognitive behavioural therapy for insomnia (eCBTI) to prevent the transition from episodic insomnia to persistent insomnia: study protocol for a randomised controlled trial
Authors: Yang Yuan , Luo Xian , Paudel Dhirendra , Zhang Jihui , Li Shirley Xin , Zhang Bin 
Published: November 2019

IntroductionPrevious evidence suggested that online self-guided sleep intervention is efficacious in improving treatment outcomes in patients with persistent insomnia. However, research on online sleep interventions targeting episodic insomnia has been scarce. This study aims to evaluate the effectiveness of brief e-aid cognitive behavioural therapy for insomnia (eCBTI) in preventing transition from episodic insomnia to persistent insomnia.Methods and analysisThis is a pragmatic two-arm multicentre, randomised controlled trial comparing eCBTI with treatment as usual (TAU) in outpatients. Two hundred patients with episodic insomnia (as defined by DSM-5) will be recruited. Patients will be randomly assigned to receive 1 week eCBTI via a Smartphone application, or to receive TAU. Treatment effects will be assessed at 1 week and 3 months after intervention. The primary outcome of the study, whether the eCBTI program is sufficient in preventing transition from short-term to persistent insomnia, is measured by the Insomnia Severity Index. Secondary outcome measurements include the Dysfunctional Beliefs and Attitudes about Sleep Scale, Ford Insomnia Response to Stress Test, Sleep Hygiene and Practices Scale, Pre-sleep Arousal Scale and Epworth Sleepiness Scale. Additionally, the Hospital Anxiety and Depression Scale and the Short-Form 12-Item Health Survey will be used for measurement of mood symptoms and quality of life.Ethics and disseminationEthical approval for the study has been obtained from the Ethics Committee of Southern Medical University (reference number: NFEC-2017–131). The results of the investigation will be published in scientific papers. The data from the investigation will be made available online if necessary.Trial registrationNCT03302455 (clinicaltrials.gov). Date of registration: October 5, 2017.
Prediction modelling of 1-year outcomes to a personalized lifestyle intervention for Canadians with metabolic syndrome
Authors: Lowry Dana E. , Feng Zeny , Jeejeebhoy Khursheed , Dhaliwal Rupinder , Brauer Paula , Royall Dawna , Tremblay Angelo , Klein Doug , Mutch David M. 
Published: November 2019

Metabolic syndrome (MetS) comprises a cluster of risk factors that includes central obesity, hypertension, dyslipidemia, and impaired glucose homeostasis. Although lifestyle interventions reduce MetS risk, not everyone responds to the same extent. The primary objective of this study was to identify variables that could predict 1-year changes in MetS risk in individuals participating in the Canadian Health Advanced by Nutrition and Graded Exercise (CHANGE) program. Participants were allocated into training (n = 157) and test (n = 29) datasets by availability of genetic data. A linear mixed-effect model revealed that age, medication, fasting glucose, triglycerides, high-density lipoprotein cholesterol, waist circumference, systolic blood pressure, and fibre intake were associated with continuous MetS (cMetS) score across all time points. Multiple linear regressions were then used to build 2 prediction models using 1-year cMetS score as the outcome variable. Model 1 included only baseline variables and was 38% accurate for predicting cMetS score. Model 2 included both baseline variables and the 3-month change in cMetS score and was 86% accurate. As a secondary objective, we also examined if we could build a model to predict a person’s categorical response bin (i.e., positive responder, nonresponder, or adverse responder) at 1 year using the same variables. We found 72% concordance between predicted and observed outcomes. These various prediction models need to be further tested in independent cohorts but provide a potentially promising new tool to project patient outcomes during lifestyle interventions for MetS. Novelty Short-term changes in cMetS score improve prediction model performance compared with only baseline variables. Predictive models could potentially facilitate clinical decision-making for personalized treatment plans.
High-energy resummation in heavy-quark pair hadroproduction
Authors: Bolognino A. D. , Celiberto Francesco Giovanni , Fucilla M. , Ivanov D. Yu. , Papa A. 
Published: November 2019

AbstractThe inclusive hadroproduction of two heavy quarks, featuring a large separation in rapidity, is proposed as a novel probe channel of the Balitsky–Fadin–Kuraev–Lipatov (BFKL) approach. In a theoretical setup which includes full resummation of leading logarithms in the center-of-mass energy and partial resummation of the next-to-leading ones, predictions for the cross section and azimuthal coefficients are presented for kinematic configurations typical of current and possible future experimental analyses at the LHC.
Well-order as a construction principle for physical theories
Authors: Schust Peter 
Published: November 2019

AbstractPhysics has up to now missed to express in mathematical terms the fundamental idea of events of a path in time and space uniquely succeeding one another. An appropriate mathematical concept that reflects this idea is a well-ordered set. In such a set every subset has a least element. Thus every element of a well-ordered set has as its definite successor the least element of the subset of all elements larger than itself. This is apparently contradictory to the densely ordered real number lines which conventionally constitute the coordinate axes in any representation of time and space and in which between any two numbers exists always another number. In this article it is shown how decomposing this disaccord in favour of well-ordered sets causes spacetime to be discontinuous.
Bounds on the signed total Roman 2-domination in graphs
Authors: Khoeilar R. , Shahbazi L. , Sheikholeslami S. M. , Shao Zehui 
Published: November 2019

Let [Formula: see text] be an integer and [Formula: see text] be a simple and finite graph with vertex set [Formula: see text]. A signed total Roman [Formula: see text]-dominating function (STR[Formula: see text]DF) on a graph [Formula: see text] is a function [Formula: see text] such that (i) every vertex [Formula: see text] with [Formula: see text] is adjacent to at least one vertex [Formula: see text] with [Formula: see text] and (ii) [Formula: see text] holds for any vertex [Formula: see text]. The weight of an STR[Formula: see text]DF [Formula: see text] is [Formula: see text] and the minimum weight of an STR[Formula: see text]DF is the signed total Roman [Formula: see text]-domination number [Formula: see text] of [Formula: see text]. In this paper, we establish some sharp bounds on the signed total Roman 2-domination number.
Live Birth Rate After Transfer of Fresh or Frozen Poor Quality Day-3 Embryos Only
Authors: Vuong Lan N. , Pham Toan D. , Huynh Bao G. , Nguyen Quynh N. , Ho Tuong M. , Norman Robert J. , Mol Ben W. 
Published: November 2019

Background: Embryo quality is an important predictor of successful outcome in in vitro fertilization (IVF). However, current knowledge on the live birth rate after transfer of poor quality embryos is limited. This study investigated the live birth rate after transfer of only poor quality day-3 embryos in women undergoing IVF. Methods: This retrospective study included 153 couples who underwent IVF at IVFMD, My Duc Hospital, Ho Chi Minh City, Vietnam between June 2014 and January 2017 and had only poor quality day-3 embryos available for fresh (n [Formula: see text] 102) or frozen (n [Formula: see text] 51) transfer. The control group included patients who had transfer of one good embryo (n [Formula: see text] 64). Embryos were rated using the Istanbul criteria. Results: In the poor quality embryo group, the mean number of oocytes retrieved and number of embryos were 7.5 ± 4.4 and 1.8 ± 0.9, respectively. Mean number of embryos transferred was 1.6 ± 0.5 in the fresh transfer group and 2.0 ± 0.2 in the freeze-only group. Live births did occur after transfer of poor quality embryos, but the implantation, clinical pregnancy and live birth rates were significantly lower than after fresh or frozen transfer of a single good quality embryo (9.5 vs. 26.6%, p < 0.001; 13.7 vs. 26.6%, p < 0.001; and 7.2 vs. 18.8%, p [Formula: see text] 0.02, respectively). Conclusions: Live birth was achieved after transfer of only poor quality embryos in women undergoing IVF. This suggests that transfer of poor quality embryos could be an option when higher grade embryos are not available, after the chances of live birth have been discussed with the patient.
Integrating Simulation and Numerical Analysis in the Evaluation of Generalized Stochastic Petri Nets
Authors: Zimmermann Armin , Hotz Thomas 
Published: November 2019

The standard existing performance evaluation methods for discrete-state stochastic models such as Petri nets either generate the reachability graph followed by a numerical solution of equations or use some variant of simulation. Both methods have characteristic advantages and disadvantages depending on the size of the reachability graph and type of performance measure.
This article proposes a hybrid performance evaluation algorithm for the steady-state solution of Generalized Stochastic Petri Nets that integrates elements of both methods. It automatically adapts its behavior depending on the available size of main memory and number of model states. As such, the algorithm unifies simulation and numerical analysis in a joint framework. It is proved to result in an unbiased estimator whose variance tends to zero with increasing simulation time.
The article extends earlier results with an algorithm variant that starts with a small maximum number of particles and increases them during the run to increase the efficiency in cases that are rapidly solved by regular simulation. The algorithm’s applicability is demonstrated through case studies, including an example where it outperforms the standard methods.
Exploiting Bank Conflict-based Side-channel Timing Leakage of GPUs
Authors: Jiang Zhen Hang , Fei Yunsi , Kaeli David 
Published: November 2019

To prevent information leakage during program execution, modern software cryptographic implementations target constant-time function, where the number of instructions executed remains the same when program inputs change. However, the underlying microarchitecture behaves differently when processing different data inputs, impacting the execution time of the same instructions. These differences in execution time can covertly leak confidential information through a timing channel.
Given the recent reports of covert channels present on commercial microprocessors, a number of microarchitectural features on CPUs have been re-examined from a timing leakage perspective. Unfortunately, a similar microarchitectural evaluation of the potential attack surfaces on GPUs has not been adequately performed. Several prior work has considered a timing channel based on the behavior of a GPU’s coalescing unit. In this article, we identify a second finer-grained microarchitectural timing channel, related to the banking structure of the GPU’s Shared Memory. By considering the timing channel caused by Shared Memory bank conflicts, we have developed a differential timing attack that can compromise table-based cryptographic algorithms. We implement our timing attack on an Nvidia Kepler K40 GPU and successfully recover the complete 128-bit encryption key of an Advanced Encryption Standard (AES) GPU implementation using 900,000 timing samples. We also evaluate the scalability of our attack method by attacking an implementation of the AES encryption algorithm that fully occupies the compute resources of the GPU. We extend our timing analysis onto other Nvidia architectures: Maxwell, Pascal, Volta, and Turing GPUs. We also discuss countermeasures and experiment with a novel multi-key implementation, evaluating its resistance to our side-channel timing attack and its associated performance overhead.
Urine α-fetoprotein and orosomucoid 1 as biomarkers of hepatitis B virus-associated hepatocellular carcinoma
Authors: Zhan Zhu , Guan Yalan , Mew Kenley , Zeng Weiqiong , Peng Mingli , Hu Peng , Yang Yixuan , Lu Yi , Ren Hong 
Published: November 2019

Hepatocellular carcinoma (HCC) is the sixth common malignant tumor worldwide, but current efficient and convenient screening methods remain lacking. This study aimed to discover a diagnostic or a screening biomarker from the urine of hepatitis B virus (HBV)-related HCC patients. We used iTRAQ coupled with mass spectrometry to identify candidate urinary proteins in a discovery cohort ( n = 40). The selected proteins were confirmed using ELISA in a validation cohort ( n = 140). Diagnostic performance of the selected proteins was assessed using receiver operating characteristic (ROC) and qualitative diagnostic analysis. A total of 96 differentially expressed proteins were identified. Urinary α-fetoprotein (u-AFP) and orosomucoid 1 (u-ORM1) were selected as target proteins by bioinformatics analysis and were significantly higher in HCC than in non-HCC patients, as validated by Western blot analysis and ELISA. u-AFP had a strong correlation with serum AFP-L3 (Pearson’s r = 0.944, P < 0.0001), indicating that u-AFP may be derived from circulating blood. The area under the curve (AUC) of u-AFP was 0.795 with a sensitivity of 62.5% and a specificity of 95.4%, which showed no significantly difference with serum AFP (se-AFP). The AUC was 0.864 as u-AFP and u-ORM1 were combined, and they performed much better than u-AFP or u-ORM1 alone. Qualitative diagnostic analysis showed that the positive predictive value of u-AFP was 90.1% and the diagnostic sensitivity of parallel combination of u-AFP and u-ORM1 was 85.1%. Taken together, AFP and ORM1 in the urine may be used as a diagnostic or screening biomarker of HCC, and studies on large samples are needed to validate the result. NEW & NOTEWORTHY This study provides a novel way to find biomarkers of hepatocellular carcinoma (HCC) and a new perspective of α-fetoprotein clinical application. The urine reagent strips may be helpful in high epidemic areas of HCC and in low-resource settings.
Expression Patterns of Xenobiotic-Metabolizing Enzymes in Tumor and Adjacent Normal Mucosa Tissues among Patients with Colorectal Cancer: The ColoCare Study
Authors: Beyerle Jolantha , Holowatyj Andreana N. , Haffa Mariam , Frei Eva , Gigic Biljana , Schrotz-King Petra , Boehm Juergen , Habermann Nina , Stiborova Marie , Scherer Dominique , Kölsch Torsten , Skender Stephanie , Becker Nikolaus , Herpel Esther , Schneider Martin , Ulrich Alexis , Schirmacher Peter , Chang-Claude Jenny , Brenner Hermann , Hoffmeister Michael , Haug Ulrike , Owen Robert W. , Ulrich Cornelia M. 
Published: November 2019

AbstractBackground:Xenobiotic-metabolizing enzymes (XME) play a critical role in the activation and detoxification of several carcinogens. However, the role of XMEs in colorectal carcinogenesis is unclear.Methods:We investigated the expression of XMEs in human colorectal tissues among patients with stage I–IV colorectal cancer (n = 71) from the ColoCare Study. Transcriptomic profiling using paired colorectal tumor and adjacent normal mucosa tissues of XMEs (GSTM1, GSTA1, UGT1A8, UGT1A10, CYP3A4, CYP2C9, GSTP1, and CYP2W1) by RNA microarray was compared using Wilcoxon rank-sum tests. We assessed associations between clinicopathologic, dietary, and lifestyle factors and XME expression with linear regression models.Results:GSTM1, GSTA1, UGT1A8, UGT1A10, and CYP3A4 were all statistically significantly downregulated in colorectal tumor relative to normal mucosa tissues (all P ≤ 0.03). Women had significantly higher expression of GSTM1 in normal tissues compared with men (β = 0.37, P = 0.02). By tumor site, CYP2C9 expression was lower in normal mucosa among patients with rectal cancer versus colon cancer cases (β = −0.21, P = 0.0005). Smokers demonstrated higher CYP2C9 expression levels in normal mucosa (β = 0.17, P = 0.02) when compared with nonsmokers. Individuals who used NSAIDs had higher GSTP1 tumor expression compared with non-NSAID users (β = 0.17, P = 0.03). Higher consumption of cooked vegetables (&gt;1×/week) was associated with higher CYP3A4 expression in colorectal tumor tissues (β = 0.14, P = 0.007).Conclusions:XMEs have lower expression in colorectal tumor relative to normal mucosa tissues and may modify colorectal carcinogenesis via associations with clinicopathologic, lifestyle, and dietary factors.Impact:Better understanding into the role of drug-metabolizing enzymes in colorectal cancer may reveal biological differences that contribute to cancer development, as well as treatment response, leading to clinical implications in colorectal cancer prevention and management.