bluuebunny/crossref_metadata_2025_split huggingface dataset:
УТОЧНЕНИЕ РЕФЕРЕНСНЫХ ИНТЕРВАЛОВ ПОКАЗАТЕЛЕЙ БИОХИМИЧЕСКОГО СОСТАВА КРОВИ У КОРОВ С УЧЁТОМ СТАДИЙ РЕПРОДУКТИВНО-ЛАКТАЦИОННОГО ЦИКЛА
Authors: Василевский Н.В. 
Published: December 2024

Необходимость уточнения референсных интервалов биохимических показателей крови связана с тем, что качественная оценка текущего физиологического статуса животного невозможна без учёта широкого спектра биохимического и клеточного состава крови. В то же время однозначная интерпретация полученных результатов исследования крови для оценки физиологического состояния лактирующих коров не всегда однозначна и зачастую ограничиваются констатацией факта невыхода этих показателей за пределы нормы. Описанные в литературе референсные диапазоны определяются на клинически здоровых животных в пределах 95%-ного доверительного интервала, при этом обычно не учитывается возможный сдвиг значений показателей к границам «нормы» у животных с субклиническими бессимптомными расстройствами, что крайне важно для ранней диагностики нарушений. Для повышения качества физиологического мониторинга в технологических группах за счёт комплексной оценки всего спектра измеряемых показателей ранее был предложен вариант использования квалиметрического анализа. Полученные результаты показали, что на распределение границ референсных интервалов биохимических показателей крови у коров оказывают фазы репродуктивно-лактационного цикла.
The need to clarify the reference intervals of biochemical blood parameters is due to the fact that a qualitative assessment of the current physiological status of an animal is impossible without taking into account a wide range of biochemical and cellular blood composition. At the same time, an unambiguous interpretation of the results of a blood test to assess the physiological state of lactating cows is not always unambiguous and is often limited to stating the fact that these indicators do not go beyond the norm. The reference ranges described in the literature are determined on clinically healthy animals within a 95% confidence interval, while a possible shift in the values of indicators to the boundaries of the “normal” in animals with subclinical asymptomatic disorders is usually not taken into account, which is extremely important for early diagnosis of disorders. To improve the quality of physiological monitoring in technological groups through a comprehensive assessment of the entire range of measured indicators, a variant of using qualimetric analysis was previously proposed. The obtained results showed that the distribution of the boundaries of the reference intervals of biochemical blood parameters in cows is influenced by the phases of the reproductive-lactation cycle.
ПРИЕМЫОПТИМИЗАЦИИУСЛОВИЙВЫРАЩИВАНИЯОЗИМОЙТВЕРДОЙПШЕНИЦЫВОРОШАЕМОЙЗОНЕДАГЕСТАНА
Authors: Магомедов Н.Р. , Магомедов Н.Н. , Абдуллаев Ж.Н. , Абдуллаев А.А. 
Published: December 2024

Представлены результаты исследований по изучению влияния различных доз минеральных удобрений и систем обработки почвы на урожайность и качество зерна нового сорта озимой твердой пшеницы Крупинка. Опыт заложен в опытной станции им. Кирова ФГБНУ ФАНЦ РД на луговокаштановой тяжелосуглинистой почве равнинной зоны Дагестана в условиях орошения. В результате проведенных исследований установлено, что максимальная урожайность озимой твердой пшеницы 5,58 т/га, в среднем за 20142019 гг., достигнута в варианте внесения повышенной дозы минеральных удобрений (N180P100) на фоне полупаровой системы обработки почвы, что на 55,1 больше, чем на контроле (без удобрений). Применение системы обработки почвы по типу поливного полупара приводило к снижению урожайности в варианте внесения повышенной дозы минеральных удобрений (N180P100) по сравнению с полупаровой системой на 0,49 т/га, или на 8,8 .
The results of studies on the effect of different doses of mineral fertilizers and tillage systems on the yield and quality of grain of a new variety of winter durum wheat Grain are presented. The experience lies in the experimental station. Kirov RUSSIAN FANZ R on meadowchestnut loamy soil of the lowland areas of Dagestan in the context of irrigation. As a result of the studies, it was found that the maximum yield of winter hard wheat 5.58 t/ha, on average for 20142019, was achieved in the variant of introduction of an increased dose of mineral fertilizers (N180P100) against the background of a semisoil treatment system, which is 55.1 more than under control ( without fertilizers). The application of the system of tillage in type of irrigation polupar led to lower yields in option of introducing high doses of mineral fertilizers (N180P100) compared with the semisteam system is 0.49 t/ha, or 8.8 .
Implementation of Inventory Checking System Using Finite State Machine in Role Playing Game
Authors: Kusuma Ahmad Fauzi Anggi Ariesta , Handayani Riska Dwi 
Published: December 2024

This study aims to implement an inventory checking system combined with Finite State Machine (FSM) in the Role Playing Game (RPG) game genre using Arnold Hendrick's Game Development Life Cycle (GDLC) development method. In RPG games, inventory management is a crucial aspect that affects the gameplay, especially in the management of quests and item crafting features. The FSM approach is used to manage state and state transitions in randomly completed quests, providing more flexible dynamics in the completion of in-game tasks. The GDLC method was chosen to ensure that system development is carried out in a structured manner, starting from planning, design, implementation, to testing. This research integrates FSM in the RPG Maker MV game engine, which allows developers to dynamically set various quest variables and optimize the item crafting process. By implementing FSM, items can be combined based on predefined state conditions, creating a more complex and interactive gameplay experience. The results of this study show that the application of FSM in the inventory checking system has a significant impact on flexibility in quest management and crafting. Quest variables that can be completed freely according to the player's choice, Overall, Finite State Machine can provide interactivity and depth of gameplay in RPGs with various quests that are tiered with each level, especially in the use of RPG Maker MV as an engine to apply various supporting variables to create flexibility in completing missions.
Pengaruh Latar Belakang Ekonomi, Pendidikan, dan Motivasi Orang Tua terhadap Prestasi Siswa SDN 02 Sukorejo Kulon
Authors: Pusporini Endang , Arifin Zainal , Surindra Bayu 
Published: December 2024

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh: 1) Status ekonomi orang tua terhadap prestasi belajar. 2) Latar belakang pendidikan orang tua terhadap prestasi belajar. 3) Motivasi orang tua terhadap prestasi belajar. 4) Status sosial ekonomi, pendidikan, dan motivasi orang tua terhadap hasil belajar anak. Kuesioner berbasis skala Likert digunakan untuk mengumpulkan data dimana teknik sampling yang digunakan yaitu sampling jenuh, yang kemudian dianalisis dengan menggunakan uji asumsi klasik, regresi linier berganda, uji hipotesis, dan koefisien determinasi pada sampel jenuh sebanyak 43 responden dengan menggunakan metode kausalitas kuantitatif. Hasil menunjukkan bahwa semua variabel berpengaruh signifikan terhadap prestasi belajar, dengan latar belakang ekonomi (sig. 0,000), pendidikan (sig. 0,024), dan motivasi belajar (sig. 0,000) masing-masing memiliki nilai signifikansi < 0,05. Secara simultan, ketiga faktor ini juga berpengaruh signifikan dengan nilai sig. 0,002. Penelitian ini tidak hanya mengevaluasi dampak masing-masing faktor secara terpisah, tetapi juga mengkaji bagaimana kombinasi ketiganya mempengaruhi prestasi belajar siswa.
Studi Potensi Air Pada Pembangkit Listrik Tenaga Air (PLTA) Tabulahan
Authors: Sabrina Dita , Faisal Zulvyah , Taufik Iqbal Muhammad , Aziz Pratiwi , Minarni Teti 
Published: December 2024

This study analyzes the potential and operational planning of the Tabulahan hydropower plant located at the Bonehau River, Periangan Village, Tabulahan District, Mamasa Regency, West Sulawesi. The project utilizes a water catchment area of 306 km² upstream of the dam and 324 km² downstream of the plant. The discharge analysis uses the Flow Duration Curve (FDC) method with the results showing adequate discharge availability. A reliable discharge of 22.80 m³/s was selected based on a reliability level of 85%-90%, with a design discharge of 8.97 m³/s for each turbine. For further planning analysis, the power generation discharge was set at Q50% (14.72 m³/second) and the river maintenance discharge (ecoflow) at Q95% (21.60 m³/second). With an installed power capacity of 10 MW, the Tabulahan hydropower plant is designed to optimize the potential of water resources with a sustainable approach.

Keywords: Reliable Discharge; Tabulahan Hydropower Plant; FDC
Abstrak: Penelitian ini menganalisis potensi dan perencanaan operasional PLTA Tabulahan yang terletak di Sungai Bonehau, Desa Periangan, Kecamatan Tabulahan, Kabupaten Mamasa, Sulawesi Barat. Proyek ini memanfaatkan daerah tangkapan air seluas 306 km² di hulu bendungan dan 324 km² di hilir rumah pembangkit. Analisis debit menggunakan metode Flow Duration Curve (FDC) dengan hasil menunjukkan ketersediaan debit yang memadai. Debit andal sebesar 22,80 m³/detik dipilih berdasarkan tingkat keandalan 85%-90%, dengan debit desain masing-masing turbin sebesar 8,97 m³/detik. Untuk analisis perencanaan lebih lanjut, debit pembangkit ditetapkan pada Q50% (14,72 m³/detik) dan debit pemeliharaan sungai (ekoflow) pada Q95% (21,60 m³/detik). Dengan kapasitas daya terpasang sebesar 10 MW, PLTA Tabulahan dirancang untuk mengoptimalkan potensi sumber daya air dengan pendekatan berkelanjutan.

Kata kunci : Debit Andal; PLTA Tabulahan; FDC
FAKTOR RESIKO KEJADIAN PENYAKIT KARDIOVASKULAR PADA PEKERJA KANTORAN DI KOTA MAKASSAR
Authors: Syahri Nur Awalia , Hakim Supartina , Halimah Andi , Lestari Virny Dwiya , Nugraha Rahmat , Mahmud Isfawati 
Published: December 2024

Penyakit Tidak Menular (PTM) merupakan prokram kerja prioritas dari Kementerian Kesehatan sejakan dengan program Transformasi Kesehatan sebab 71% jumlah kematihan disebabkan oleh PTM. Sebanyak 35% dari angka tersebut adalah disebabkan oleh penyakit kardiovaskuler. Penyebab penyakit kardiovaskular ini dapat disebabkan dari berbagai faktor resiko yang berkembang sejak usia produktif 20 – 30 tahun karena pada usia ini kita menjalankan pola hidup secara optimal namun jika terjadi penurunan kualitas pola hidup pada masa tersebut maka akan berdampak pada kondisi kesehatan di masa kedepan. Penelitian ini bertujuan untuk mengetahui dan menganalisa prevalensi dan distribusi faktor-faktor resiko penyakit kardiovaskuler pada pekerja kantor yang memiliki keterbatasan aktivitas fisik diakrenakan kesibukan pekerjaan di kantor. Penelitian ini menunjukkan sebanyak 83.33% pekerja duduk (tanpa aktivitas fisik) dengan durasi di atas 6 jam dan ditambah dengan presentasi yang tinggi terhadap riwayat hipertensi sebesar 13.33% dan mengalami kolesterol tinggi sebanyak 23.33%. Hal ini menunjukkan keterlibatan berbagai jenis faktor resiko dapat berpotensi meningkatkan kejadian penyakit kardiovaskular.
Pemeriksaan TCM (Tes Cepat Molekuler ) Pada Kontak Erat Pasien Tuberkulosis di RSUD dr H.Chasan Boesoerie
Authors: Halwatiah Halwatiah , Silviani Yusianti 
Published: December 2024

Tuberkulosis (TBC) adalah penyakit infeksi bakteri Mycobacterium tuberculosis yang bersifat kronis, dapat menyerang berbagai organ seperti paru-paru, tulang, selaput otak, selaput perut, usus, kelenjar getah bening, bahkan saluran kemih.. World Health Organization (WHO) memperkirakan TBC menyebabkan kematian sebanyak 1,4 juta orang di dunia dan sekitar 5,6 juta laki-laki, 3,2 juta perempuan sama dengan 130 kasus per 100.000 jiwa per tahun 2019. Penularan TBC umumnya terjadi melalui udara. Ketika penderita TBC aktif memercikkan lendir atau dahak saat batuk atau bersin, bakteri TBC akan ikut keluar melalui lendir tersebut dan terbawa ke udara. Tujuan penelitian ini adalah untuk mengetahui hasil pemeriksaan TCM kontak erat pada pasien Tuberkulosis paru di RSUD dr. H. Chasan Boesoirie Ternate. Penelitian ini dilakukan di RSUD. Chasan Boesorie Kota Ternate, data penelitian ini diperoleh dari data primer dengan menggunakan metode deskriftif observasional dengan desain studi Cross Sectional dengan teknik purposive sampling pada 10 pasien yang terkonfirmasi positif TBC pada TCM.dengan melakukan pemeriksaan TCM terhadap kontak erat serumah didapatkan 23 kontak dari 10 Pasien TBC. Berdasarkan hasil penelitian didapati hasil positif TBC sebanyak 4% pada pemeriksaan TCM dari 23 kontak erat pasien TBC di RSUD dr. H. Chasan Boesoirie Ternate. Ditemukan 1 orang kontak erat TBC positif menderita tuberculosis.
Kata Kunci : TBC, kontak erat serumah, pemeriksaan TCM
ВИКОРИСТАННЯ МЕТОДИКИ КОРЕКЦІЇ СЕМАНТИЧНИХ ПОЛІВ СЛІВ ДІТЕЙ ДОШКІЛЬНОГО ВІКУ ІЗ ЗАГАЛЬНИМ НЕДОРОЗВИНЕННЯМ МОВЛЕННЯ
Authors: Ткач Оксана 
Published: December 2024

Статтю присвячено опису методики корекції семантичних полів слів. Визначено її основні завдання, мовленнєвий матеріал та умови його використання. Обґрунтовано принципи поділу матеріалу на освітні напрями та уточнено цілі цього вибору, визначено критерії підбору матеріалу (тематичний принцип, лінгвістичний, морфологічний, частотний, ієрархічний та ін.). Дані принципи дали змогу сформувати опорні групи лексики для дітей старшого дошкільного віку, враховуючи їх лінгвістичний досвід та вимоги програм для дітей з тяжкими порушеннями мовлення.
Описано три основні етапи здійснення корекційної програми, їх мету та напрями роботи. Це актуалізація вже існуючих знань дитини, розширення лексичного значення за рахунок накопичення нових слів та використання семантичних зв’язків для вбудовування їх в існуючі семантичні поля. Найважливішим виявився етап гармонізації, структуризації та реполяризації семантичних полів, де створювалися умови для самостійної побудови та видозміни семантичних полів, оскільки передбачав самостійну усвідомлену роботу дітей з підбору, обробки та використання інформації, отриманої з різних джерел та галузей знань, тобто формування вміння за власним вибором чи інструкцією трансформувати вже існуючі семантичні поля.
У статті подано перелік практичних завдань, що пропонувалися дітям на різних етапах корекції для індивідуальної та групової роботи. Діти працювали з готовими графічними структурами висловлювань та динамічними моделями. Для візуалізації процесу формування семантичних полів, окрім загальноприйнятих моделей (асоціативні ланцюжки), було запропоновано проективні моделі («калинове гроно», «сонячний годинник», «асоціативний кущ» та «багатоступінчата піраміда»), які дали можливість вивчити кількісні та якісні характеристики семантичних полів.
Bone mineral density and uric acid level in postmenopausal women
Authors: Toroptsova N. V. , Dobrovolskaya O. V. , Kozyreva M. V. , Demin N. V. 
Published: December 2024

Aim: to study the association between bone mineral density (BMD) and uric acid (UA) level in postmenopausal women. Materials and methods. 263 women were examined (median age 62 [56; 67] years). A clinical examination and assessment of UA level were performed. Dual-energy X-ray absorptiometry was done to assess BMD in standard regions of interest (ROI): lumbar spine (L1-L4), femoral neck (FB) and total hip (TH) and trabecular bone score (TBS). Results. The frequency of hyperuricemia in postmenopausal women was 12.5 %, and in persons with osteoporosis (OP) – 10.1 %. UA correlated significantly with BMD and T-score in L1-L4 (r = 0.20 and r = 0.19, respectively) and TH (r = 0.18 and r = 0.16, respectively). No correlation was found between UA and TBS value (p > 0.05). Linear regression analysis adjusted for age showed a significant association between UA and BMD in all ROI (b*L1-L4 = 0.21, p = 0.001; b*FN = 0.14, p = 0.024; b*TH = 0.20, p = 0.002). In women with UA level ≥ 200 mmol/l, the BMD and T-score in all ROI were significantly higher, and the frequency of OP was lower compared with women with UA < 200 mmol/l (p < 0.05 for all comparison). Conclusion. Hyperuricemia was found in 12.5 % of postmenopausal women, and in 10.1 % of patients with OP. Significant differences in BMD, T-score, and OP frequency were found in all ROI, depending on the UA level. The mean value of TBS and the frequency of degraded bone microarchitecture did not differ depending on the UA level.
Two decades of research on Borrelia burgdorferi sensu lato in questing Ixodes ricinus ticks in Slovakia
Authors: Rusňáková Tarageľová Veronika , Derdáková Markéta , Selyemová Diana , Chvostáč Michal , Mangová Barbara , Didyk Yuliya M. , Koči Juraj , Kolenčík Stanislav , Víchová Bronislava , Peťko Branislav , Stanko Michal , Kazimírová Mária 
Published: December 2024

IntroductionIn Europe, Borrelia burgdorferi sensu lato (s.l.), the causative agent of Lyme borreliosis is transmitted by the castor bean tick, Ixodes ricinus. In the last decades, global changes affect the spread of ticks and also their bionomics. The aim of this study was summarization of a large dataset obtained during 20 years of research.MethodsThe research was carried out in 1999-2019 at 16 localities in Slovakia that were continuously monitored. In total, 17,249 questing I. ricinus ticks were tested for the presence of B. burgdorferi s.l. ResultsThe total prevalence of infected ticks was 18.8% (3,248/17,249), with 15.1% (1,557/10,302) infected nymphs and 24.3% (1,691/6,947) infected adults. Nine species of B. burgdorferi s.l. were identified. Borrelia afzelii (37.1%), B. garinii/bavariensis (24.7%), and B. valaisiana (15.4%) were the most frequent and were present at all study sites, followed by B. lusitaniae (12.6%), B. burgdorferi sensu stricto (4.1%) and B. spielmanii (1.6%). Borrelia bavariensis was confirmed only in four samples (0.1%), however, detection of this species has been performed only since 2017. Borrelia bissettii and B. kurtenbachii were both recorded in one case. The total prevalence differed significantly among four habitat types (urban, suburban, natural, agricultural). The highest infection prevalence was confirmed in natural habitat (22.0%), the lowest in urban habitat (13.2%). In addition, molecular analysis was carried out on part of the collected ticks previously morphologically identified as I. ricinus. The analysis did not confirm the occurrence of Ixodes inopinatus in Slovakia.ConclusionLong-term monitoring of the abundance and spread of ticks as well as the prevalence and genetic variability of tick-borne pathogens can reveal the impact of global climatic and socio-economic changes on different habitats, including natural foci of tick-borne pathogens.
Cross-disease transcriptomic analysis reveals DOK3 and PAPOLA as therapeutic targets for neuroinflammatory and tumorigenic processes
Authors: Wang Xingqiao , Bian Yusong , Chen Weiguang 
Published: December 2024

ObjectiveSubarachnoid hemorrhage (SAH) and tumorigenesis share numerous biological complexities; nevertheless, the specific gene expression profiles and underlying mechanisms remain poorly understood. This study aims to identify differentially expressed genes (DEGs) that could serve as biomarkers for diagnosis and prognosis.MethodsGene expression datasets (GSE122063, GSE13353, GSE161870) were analyzed using machine learning algorithms and logistic regression to identify DEGs associated with both SAH and tumorigenesis. Lasso regression and receiver operating characteristic (ROC) curve analysis were employed to evaluate the classification accuracy of these genes. Validation of critical DEGs was performed through pan-cancer analysis and experimental studies, focusing on the role of DOK3 in modulating inflammation and oxidative stress in U251MG glioblastoma and BV2 microglia cells.ResultsFifteen common DEGs were identified, with DOK3 and PAPOLA highlighted as crucial genes implicated in SAH and neurodegenerative processes. Experimental validation demonstrated that DOK3 overexpression significantly reduced pro-inflammatory cytokine levels and oxidative stress markers while enhancing antioxidant enzyme activity. Additionally, DOK3 influenced tumorigenic processes such as apoptosis, cell cycle regulation, and proliferation, effectively mitigating LPS-induced cytotoxicity and inflammation in BV2 microglial cells.ConclusionsDOK3 and PAPOLA play critical roles in both SAH and related neurodegeneration, presenting themselves as potential prognostic biomarkers and therapeutic targets. Notably, DOK3 exhibits potential as an antitumor agent with anti-inflammatory and antioxidative properties, offering therapeutic benefits for both cancer and neuroinflammatory conditions.
Effects of intermittent visual feedback on EEG characteristics during motor preparation and execution in a goal-directed task
Authors: Yu Baobao , You Yimeng , Li Yahui , Chen Jiaqi , Zhou Huilin , Wang Jun , Huang Junchen , Fan Weinv , Xu Jialin , Zuo Guokun 
Published: December 2024

IntroductionVisual feedback plays a crucial role in goal-directed tasks, facilitating movement preparation and execution by allowing individuals to adjust and optimize their movements. Enhanced movement preparation and execution help to increase neural activity in the brain. However, our understanding of the neurophysiological mechanisms underlying different types of visual feedback during task preparation and execution remains limited. Therefore, our study aims to investigate the impact of different types of visual feedback on movement-related brain activity in goal-directed tasks, in order to identify more effective forms of visual feedback in goal-directed tasks.MethodsThe electroencephalographic (EEG) data from 18 healthy subjects were collected under both continuous and intermittent visual feedback conditions during a goal-directed reaching task. We analyzed the EEG characteristics of the event-related potential (ERP), event-related synchronization/desynchronization (ERS/ERD) in all subjects during motor preparation and execution of the goal-directed reaching task.ResultsThe results showed that, the amplitude of motor-related cortical potential (MRCP) in subjects was larger in the intermittent visual feedback condition compared to the continuous visual feedback condition during motor preparation, and the amplitude was largest at the CPz electrode. Additionally, mu-ERD was more pronounced during both motor preparation and execution under intermittent visual feedback condition.DiscussionIn conclusion, intermittent visual feedback enhanced the characteristics of subject’s brain activation and cortical excitability in the time and time-frequency domains.