bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of PrEP eligibility and uptake among at-risk MSM participating in a HIV-1 vaccine feasibility cohort in coastal Kenya
Authors: Wahome Elizabeth , Graham Susan , Thiong’o Alexander , Chirro Oscar , Mohamed Khamisi , Gichuru Evans , Mwambi John , Price Matt , Sanders Eduard J. 
Published: March 2020

Introduction: Pre-exposure prophylaxis (PrEP) is provided free of costs to at-risk populations in Kenya, including men who have sex with men (MSM), but anal intercourse is not an eligibility criterion. We set out to determine PrEP eligibility, uptake and predictors of PrEP uptake among MSM enrolled in an HIV-1 vaccine feasibility cohort in coastal Kenya. Methods: We compared the number of MSM identified as eligible for PrEP from June-December 2017 by Kenyan Ministry of Health (MoH) criteria, which do not include reported anal intercourse, to those identified as eligible by a published MSM cohort-derived HIV-1 risk score (CDHRS). We determined PrEP uptake and assessed factors associated with uptake at first offer among eligible MSM followed up monthly. Results: Out of 167 MSM assessed for PrEP eligibility, 118 (70.7%) were identified by both MoH and CDHRS eligibility criteria; 33 (19.8%) by CDHRS alone, 11 (6.6%) by MoH criteria alone, and 5 (3.0%) by neither criterion. Of the men identified by CDHRS alone, the majority (24 or 72.7%) reported receptive anal intercourse (RAI). Of the 162 MSM eligible for PrEP, 113 (69.7%) accepted PrEP at first offer. Acceptance of PrEP was higher for men reporting RAI (adjusted prevalence ratio [aPR], 1.4; 95% confidence interval [CI], 1.0–1.9), having paid for sex (aPR, 1.3; 95% CI, 1.1–1.6) and group sex (aPR, 1.4; 95% CI, 1.1–1.8), after adjustment for sociodemographic factors. Conclusions: Assessing PrEP eligibility using the CDHRS identified 20% more at-risk MSM for PrEP initiation than when Kenyan MoH criteria were used. Approximately 70% of eligible men accepted PrEP at first offer, suggesting that PrEP is acceptable among at-risk MSM. MSM reporting RAI, group sex, or paying for sex were more likely to accept PrEP. Incorporating RAI into MoH PrEP eligibility criteria would enhance the impact of PrEP programming in Kenya.
Increased severity of anaemia is associated with 30-day complications following total joint replacement
Authors: Gu Alex , Malahias Michael-Alexander , Selemon Nicolas A. , Wei Chapman , Gerhard Eleanor F. , Cohen Jordan S. , Fassihi Safa C. , Stake Seth , Bernstein Sophie L. , Chen Aaron Z. , Sculco Thomas P. , Cross Michael B. , Liu Jiabin , Ast Michael P. , Sculco Peter K. 
Published: March 2020

Aims The aim of this study was to determine the impact of the severity of anaemia on postoperative complications following total hip arthroplasty (THA) and total knee arthroplasty (TKA). Methods A retrospective cohort study was conducted using the American College of Surgeons National Quality Improvement Program (ACS-NSQIP) database. All patients who underwent primary TKA or THA between January 2012 and December 2017 were identified and stratified based upon hematocrit level. In this analysis, we defined anaemia as packed cell volume (Hct) < 36% for women and < 39% for men, and further stratified anaemia as mild anaemia (Hct 33% to 36% for women, Hct 33% to 39% for men), and moderate to severe (Hct < 33% for both men and women). Univariate and multivariate analyses were used to evaluate the incidence of multiple adverse events within 30 days of arthroplasty. Results Following adjustment, patients in the THA cohort with moderate to severe anaemia had an increased odds of 6.194 (95% confidence interval (CI) 5.679 to 6.756; p < 0.001) for developing any postoperative complication. Following adjustment, patients in the TKA cohort with moderate to severe anaemia had an increased odds of 5.186 (95% CI 4.811 to 5.590; p < 0.001) for developing any postoperative complication. Among both cohorts, as severity increased, there was an increased risk of postoperative complications. Conclusion Preoperative anaemia is a risk factor for complications following primary arthroplasty. There is a significant relationship between the severity of anaemia and the odds of postoperative complications. Patients who had moderate to severe anaemia were at increased risk of developing postoperative complications relative to patients with mild anaemia. When considering elective primary THA or TKA in a moderately or severely anaemic patient, surgeons should strongly consider correcting anaemia prior to surgery if possible. Cite this article: Bone Joint J 2020;102-B(4):485–494.
Patellofemoral arthroplasty is cheaper and more effective in the short term than total knee arthroplasty for isolated patellofemoral osteoarthritis: cost-effectiveness analysis based on a randomized trial
Authors: Fredborg Charlotte , Odgaard Anders , Sørensen Jan 
Published: March 2020

Aims The aim is to assess the cost-effectiveness of patellofemoral arthroplasty (PFA) in comparison with total knee arthroplasty (TKA) for the treatment of isolated patellofemoral osteoarthritis (OA) based on prospectively collected data on health outcomes and resource use from a blinded, randomized, clinical trial. Methods A total of 100 patients with isolated patellofemoral osteoarthritis were randomized to receive either PFA or TKA by experienced knee surgeons trained in using both implants. Patients completed patient-reported outcomes including EuroQol five-dimension questionnaire (EQ-5D) and 6-Item Short-Form Health Survey questionnaire (SF-6D) before the procedure. The scores were completed again after six weeks, three, six, and nine months, and again after one- and two-year post-surgery and yearly henceforth. Time-weighted outcome measures were constructed. Cost data were obtained from clinical registrations and patient-reported questionnaires. Incremental gain in health outcomes (quality-adjusted life-years (QALYs)) and incremental costs were compared for the two groups of patients. Net monetary benefit was calculated assuming a threshold value of €10,000, €35,000, and €50,000 per QALY and used to test the statistical uncertainty and central assumptions about outcomes and costs. Results The PFA group had an incremental 12 month EQ-5D gain of 0.056 (95% confidence interval (CI) 0.01 to 0.10) and an incremental 12 month cost of minus €328 (95% CI 836 to 180). PFA therefore dominates TKA by providing better and cheaper outcomes than TKA. The net monetary benefit of PFA was €887 (95% CI 324 to 1450) with the €10,000 threshold, and it was consistently positive when different measures of outcomes and different cost assumptions were used. Conclusion This study provides robust evidence that PFA from a one-year hospital management perspective is cheaper and provides better outcomes than TKA when applied to patients with isolated patellofemoral osteoarthritis and performed by experienced knee surgeons. Cite this article: Bone Joint J 2020;102-B(4):449–457.
The effect of anterior cruciate ligament resection on knee biomechanics
Authors: Kayani Babar , Konan Sujith , Ahmed Syed S , Chang Justin S , Ayuob Atif , Haddad Fares S 
Published: March 2020

Aims The objectives of this study were to assess the effect of anterior cruciate ligament (ACL) resection on flexion-extension gaps, mediolateral soft tissue laxity, maximum knee extension, and limb alignment during primary total knee arthroplasty (TKA). Methods This prospective study included 140 patients with symptomatic knee osteoarthritis undergoing primary robotic-arm assisted TKA. All operative procedures were performed by a single surgeon using a standard medial parapatellar approach. Optical motion capture technology with fixed femoral and tibial registration pins was used to assess study outcomes pre- and post-ACL resection with knee extension and 90° knee flexion. This study included 76 males (54.3%) and 64 females (45.7%) with a mean age of 64.1 years (SD 6.8) at time of surgery. Mean preoperative hip-knee-ankle deformity was 6.1° varus (SD 4.6° varus). Results ACL resection increased the mean extension gap significantly more than the flexion gap in the medial (mean 1.2 mm (SD 1.0) versus mean 0.2 mm (SD 0.7) respectively; p < 0.001) and lateral (mean 1.1 mm (SD 0.9) versus mean 0.2 mm (SD 0.6) respectively; p < 0.001) compartments. The mean gap differences following ACL resection did not create any significant mediolateral soft tissue laxity in extension (gap difference: mean 0.1 mm (SD 2.4); p = 0.89) or flexion (gap difference: mean 0.2 mm (SD 3.1); p = 0.40). ACL resection did not significantly affect maximum knee extension (change in maximum knee extension = mean 0.2° (SD 0.7°); p = 0.23) or fixed flexion deformity (mean 4.2° (SD 3.2°) pre-ACL release versus mean 3.9° (SD 3.7°) post-ACL release; p = 0.61). ACL resection did not significantly affect overall limb alignment (change in alignment = mean 0.2° valgus (SD 1.0° valgus; p = 0.11). Conclusion ACL resection creates flexion-extension mismatch by increasing the extension gap more than the flexion gap. However, gap differences following ACL resection do not create any mediolateral soft tissue laxity in extension or flexion. ACL resection does not affect maximum knee extension or overall limb alignment. Cite this article: Bone Joint J 2020;102-B(4):442–448.
Complications following surgery for adolescent idiopathic scoliosis over a 13-year period
Authors: Kwan Kenny Y. H. , Koh Hui Y. , Blanke Kathleen M. , Cheung Kenneth M. C. 
Published: March 2020

Aims The purpose of this study was to evaluate the incidence and analyze the trends of surgeon-reported complications following surgery for adolescent idiopathic scoliosis (AIS) over a 13-year period from the Scoliosis Research Society (SRS) Morbidity and Mortality database. Methods All patients with AIS between ten and 18 years of age, entered into the SRS Morbidity and Mortality database between 2004 and 2016, were analyzed. All perioperative complications were evaluated for correlations with associated factors. Complication trends were analyzed by comparing the cohorts between 2004 to 2007 and 2013 to 2016. Results Between 2004 and 2016, a total of 84,320 patients were entered into the database. There were 1,268 patients associated with complications, giving an overall complication rate of 1.5%. Death occurred in 12 patients (0.014%). The three most commonly reported complications were surgical site infection (SSI) (441 patients; 0.52%), new neurological deficit (293; 0.35%), and implant-related complications (172; 0.20%). There was a statistically significant but weak correlation between the occurrence of a SSI and the magnitude of the primary curve ( r = 0.227; p < 0.001), and blood loss in surgery ( r = 0.111; p = 0.038), while the occurrence of a new neurological deficit was correlated statistically significantly but weakly with age at surgery ( r = 0.147; p = 0.004) and magnitude of the primary curve ( r = 0.258; p < 0.001). The overall complication rate decreased from 4.95% during 2004 to 2007 to 0.98% during 2013 to 2016 (p = 0.023). Conclusion An overall complication rate of 1.5% was found in our series after surgery for AIS, with a reduction of complication rates found in the second period of the analysis. Cite this article: Bone Joint J 2020;102-B(4):519–523.
Dental tooth decay profile in an institutionalized elder population of Northern Portugal
Authors: Gavinha Sandra Maria , Melo Paulo Ribeiro , Costa Liliana Gavinha , Monteiro Patrícia Manarte , Manso Maria Conceição 
Published: March 2020

Objectives: the purpose of this study was to assess the dental tooth decay profile of an elderly population from Northern Portugal. Material and Methods: this is a descriptive, cross-sectional study where a questionnaire, intended to assess the institutionalized elders oral health condition, was applied with the purpose of quantifying certain oral conditions. Tooth decay was assessed using the DMFT Index for the crown’s tooth and the individual radicular caries index (RCIi) for the root’s condition assessment. Univariate analysis and multivariable logistical regressions were performed (p < 0.05) using the IBM© SPSS© Statistics vs.19.0. Results: three hundred and seventy-two elderly participants were assessed with an average age of 78.8 years, of which 260 were women (69.9%). Of the sample 30.4% had no literacy and 18.3% were dependent on their daily oral hygiene care, 30.9% (95%CI:26.2%-35.6%) were edentulous and 84.9% (95%CI:81.3%-88.5%) had less than 20 teeth. The average number of teeth was 8.9 (±8.7) and the DMFT was 25.6 (± 7.3). The RCIi for men was 44.3% (± 30.4%) and 39.4% (± 31.2%) for women. Using multivariate logistical regression model the outcome RCIi?20% was shown to be significantly and positively associated with the use of removable partial dentures (metal partial dentures: OR=5.348 (95%CI:1.176-24,329; p = 0.030) as well as with daily tooth brushing (no toothbrushing: OR = 2.802 (95%CI:1.445-5.433); p = 0.002). Conclusion: the prevalence of tooth decay in this elder institutionalized population of Northern Portugal is high, mostly due to bad oral hygiene habits associated to the use of metal removable partial dentures. Institutionalized elderly need protocols tailored to their oral health needs and integrated efforts in the institutions are needed to effectively answer the demands related to the elderly cognitive and motor skills (ageing deterioration) decline of physiological functions.KEYWORDSElderly; Oral health; Prosthesis; Root caries.
Anisotropic problems with unbalanced growth
Authors: Alsaedi Ahmed , Ahmad Bashir 
Published: March 2020

Abstract
The main purpose of this paper is to study a general class of (p, q)-type eigenvalues problems with lack of compactness. The reaction is a convex-concave nonlinearity described by power-type terms. Our main result establishes a complete description of all situations that can occur. We prove the existence of a critical positive value λ
* such that the following properties hold: (i) the problem does not have any entire solution in the case of low perturbations (that is, if 0 < λ < λ
*); (ii) there is at least one solution if λ = λ
*; and (iii) the problem has at least two entire solutions in the case of high perturbations (that is, if λ > λ
*). The proof combines variational methods, analytic tools, and monotonicity arguments.
The Adjunction Inequality for Weyl-Harmonic Maps
Authors: Ream Robert 
Published: March 2020

AbstractIn this paper we study an analog of minimal surfaces called Weyl-minimal surfaces in conformal manifolds with a Weyl connection (M4, c, D). We show that there is an Eells-Salamon type correspondence between nonvertical 𝒥-holomorphic curves in the weightless twistor space and branched Weyl-minimal surfaces. When (M, c, J) is conformally almost-Hermitian, there is a canonical Weyl connection. We show that for the canonical Weyl connection, branched Weyl-minimal surfaces satisfy the adjunction inequality\chi \left( {{T_f}\sum } \right) + \chi \left( {{N_f}\sum } \right) \le \pm {c_1}\left( {f*{T^{\left( {1,0} \right)}}M} \right).The ±J-holomorphic curves are automatically Weyl-minimal and satisfy the corresponding equality. These results generalize results of Eells-Salamon and Webster for minimal surfaces in Kähler 4-manifolds as well as their extension to almost-Kähler 4-manifolds by Chen-Tian, Ville, and Ma.
Statistical Modelling and Optimisation of the Biosorption of Cd(II) and Pb(II) onto Dead Biomass of Pseudomonas Aeruginosa
Authors: Ighalo Joshua O. , Adeniyi Adewale George 
Published: March 2020

Abstract
Dead biomass of micro-organisms can be used as biosorbents for the mitigation of heavy metal pollution in the aqueous environment. The aim of this study was to statistically model and optimise the sorption of Cd(II) and Pb(II) by dead biomass of Pseudomonas aeruginosa and to study the interactions between operating conditions. Statistically significant models were obtained for Cd(II) and Pb(II) sorption. The standard deviation for the Cd(II) and Pb(II) models were 0.86 and 1.54 while the coefficient of determination (R2) were 0.9978 and 0.9928 respectively. For both models, the adjusted R2 was in good agreement with the predicted R2 as the difference was less than 0.2. Numerical optimisation revealed that optimum Cd(II) removal of 88.6 % can be achieved at 1.172 ppm initial metal concentration, pH of 8.85, temperature of 43.72 °C, agitation time of 125.96 minutes and dead cell mass of 114.8 mg. Also, an optimum Pb(II) removal of 100 % can be achieved at 1.936 ppm initial metal concentration, pH of 6.88, temperature of 37.24 °C, agitation time of 130.57 minutes and dead cell mass of 122.85 mg. The study has revealed that at careful selected operational parameters, dead biomass of Pseudomonas aeruginosa can be valorised for the removal of heavy metals in aqueous media.
Design of Compact Highpass Filter for 5G mm-wave Applications Using Complementary Split Ring Resonator
Authors: Ramanujam Parthasarathy , Ramesh Venkatesan P. G. , Arumugam Chandrasekar , Ponusamy Manimaran 
Published: March 2020

AbstractThis article presents a design of highpass filter (HPF) for millimeter-wave (mm-wave) applications using a square complementary split-ring resonator (SCSRR). A miniaturized size HPF filter is obtained by overlapping the Right-Hand (RH) and Left-Hand material. The arrangement of inter-digital parallel coupled capacitor and SCSRR offers low insertion loss, high selectivity with a sharp roll-off factor over a wide bandwidth of 15.9 GHz (from 34.1 to 50 GHz). Generally, SCSRR offers narrow passband/stopband however this prototype has a passband over a wide range of frequency. The proposed HPF has an appreciable agreement between simulated and fabricated results. Further, the filter is realized in the equivalent circuit model and their electrical elements functions are also discussed. This prototype has a cut-off frequency (fc) of 34.1 GHz with a maximum passband insertion loss of 1.45 dB. The fabricated area of the filter is 0.16λg × 0.09λg × λg and where λg is the guided wavelength at cutoff frequency fc.
Effect of growth stress and interlocked grain on splitting of seven different hybrid clones ofEucalyptus grandis×Eucalyptus urophyllawood
Authors: Nistal França Frederico José , Filgueira Amorim França Tâmara Suely , Vidaurre Graziela Baptista 
Published: March 2020

AbstractTrees with high levels of growth stress begin to show log end splits (LES) immediately after harvesting, usually reaching its maximum end split in a week, and these tensions also create splits during lumber manufacturing. Interlocked grain is another characteristic that impacts the properties of eucalyptus wood. The aim of this study was to evaluate the effect of growth stress and interlocked grain patterns on log end splitting of seven different hybrid clones ofEucalyptus grandis × Eucalyptus urophyllaplanted in Brazil. The growth stress indicator (GSI) was measured in standing trees before harvesting. Splits were measured on logs in three different stages, and interlocked grain from wood blocks was obtained across the center of the cross-section. The results showed that LES occurred as soon as the trees were harvested; however, for better selection of clones, LES should be evaluated after a week of harvesting. There were statistically significant correlations for GSI with LES. Clones that presented higher values of interlocked grain tended to develop lower values of GSI and LES. Using GSI and interlocked grain measurements, it was possible to select the most indicated eucalyptus clones for lumber production.
Vemurafenib downmodulates aggressiveness mediators of colorectal cancer (CRC): Low Molecular Weight Protein Tyrosine Phosphatase (LMWPTP), Protein Tyrosine Phosphatase 1B (PTP1B) and Transforming Growth Factor β (TGFβ)
Authors: Cordeiro Helon Guimarães , de Sousa Faria Alessandra Valéria , Ferreira-Halder Carmen Veríssima 
Published: March 2020

Abstract
Colorectal Cancer (CRC) therapy confronts challenges as chemoresistance and side effects. Therefore, drugs with antitumor properties that downmodulate aggressiveness mediators are required. Studies have shown the relevance of Low Molecular Weight Protein Tyrosine Phosphatase (LMWPTP), Protein Tyrosine Phosphatase 1B (PTP1B), and Transforming Growth Factor β (TGFβ) in mediating proliferation, chemoresistance, and metastasis. In this study, we aimed to investigate the responsiveness of colorectal cancer lines (HT29 and HCT116) towards Vemurafenib and whether this treatment could modulate these aggressiveness mediators. Cytotoxicity Assays (MTT and Trypan Exclusion Test) were performed to evaluate the viability of HT29 and HCT116 cells treated with Vemurafenib. Western blotting was performed to analyze the amount and/or the activity of mediators (LMWPTP, PTP1B, TGFβ, SMAD3), and the immunoprecipitation was performed to evaluate LMWPTP activity. This study brought up novel aspects of Vemurafenib action in colorectal cancer, which can decrease the activity of protein tyrosine phosphatases (LMWPTP and PTP1B) and the TGFβ pathway, making them important in the CRC aggressiveness. By downmodulating colorectal cancer hallmarks, Vemurafenib appears as an interesting candidate for CRC therapeutic protocols.
Lifetime Cost of Living and Effective Prices: Theory and Evidence for Germany
Authors: Tödter Karl-Heinz , Ziebarth Gerhard 
Published: March 2020

AbstractWe develop and analyze an intertemporal cost of living index (ICOLI), also referred to as lifetime cost of living or cost of life index. The ICOLI is a geometric weighted average of effective prices, derived from constrained consumer utility maximization. Effective prices are both, money valued marginal utilities of the final unit consumed, and present values of prices for future consumption. Using the concept of duration, we derive analytical elasticities of the ICOLI with respect to consumer prices and interest rates and show their impact on lifetime welfare of consumers. We also provide empirical evidence for Germany, compute an ex post time series of the ICOLI, and gauge the welfare effects of low interest rate scenarios. We find that the financial repression policy of the ECB since 2010 contributed to substantial losses in the purchasing power of money and led to lasting welfare losses for consumers in Germany, in particular for the cohorts of young consumers. The ICOLI complements conventional price and inflation statistics and could serve as a valuable information tool for monetary policy.