bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence-based practice work file - A learning strategy for occupational therapy students during clinical placements: a descriptive cross-sectional study
Authors: Johnson Susanne , Bruset Else Britt , Hjelle Kari Margrete , Mongs Malin , Sveen Unni 
Published: March 2020

Abstract
Background

Healthcare professionals and students are expected to work according to evidence-based practice (EBP). The EBP work file, an online learning tool that covers all steps in the EBP process, is an approach to teaching and learning EBP. The aim of this study was to examine possible differences in occupational therapy students’ self-reported attitude, skills, use and implementation of EBP during their second-year clinical placement by comparing students who applied the EBP work file with students who did not use it.

Methods

A descriptive, cross-sectional comparative study was conducted. The sample comprised three cohorts (1, 2 and 3) of second-year occupational therapy students from Western Norway University of Applied Sciences and two cohorts (4 and 5) from Oslo Metropolitan University. Five cohorts in total took part in the study (n = 126 students). The students answered two questionnaires (“EBP Beliefs Scale” and “EBP Implementation Scale”) after completing their second-year clinical placement. The analysis was based on descriptive statistics and calculation of the frequencies, percentages, means and standard deviations of all participating students’ scores on the two questionnaires. ANOVA with Bonferroni correction was conducted to analyse differences between the mean totals of the questionnaires.

Results

The response rate was 57.3%. The average scores were 56.8 on the EBP Beliefs Scale and 15.8 on the EBP Implementation Scale. Students from cohort 5 (who had extra instruction and assignments via the EBP work file) had statistically lower scores than students form cohort 1 on the Implementation Scale. These students believed that EBP results in the best clinical care for patients, but they lacked confidence in their ability to use EBP.

Conclusions

Additional EBP work-file assignments were insufficient to support students in the implementation of EBP during clinical placements. It is important to teach students EBP skills and to demonstrate how they can use this competency in their work with patients. Including clinical instructors in EBP teaching and learning seems essential.
Natural history of gastroesophageal reflux in infancy: new data from a prospective cohort.
Authors: Chotard Marlene Curien- , Jantchou Prévost 
Published: March 2020

Abstract
Objective Gastroesophageal reflux (GER) is common in infants. Gastroesophageal reflux disease (GERD) is defined as GER leading to troublesome symptoms that affect daily functioning and/or complications. This study aimed at determining the prevalence and progression of GER and GERD in a cohort of healthy term infants from birth to 12 months old. Methods We conducted a prospective cohort study including all full-term living neonates born at Besançon Teaching Hospital, France. Exclusion criteria were: congenital anomaly. Parents completed a clinical report form and the Infant Gastroesophageal Reflux Questionnaire Revised (I-GERQ-R) at 1, 3, 6, 10, and 12 months of age. GER was defined as score ≥1 to the first question with I-GERQ-R score < 16 ; and GERD as score ≥1 to the first question with I-GERQ-R score ≥ 16. Regurgitation was based on the answer to the first question of the I-GERQ-R as anything coming out of the mouth daily. Findings 157/347 births were included (83 boys). The prevalence of regurgitation at least once a day was 45.7% overall. In total: 72%, 69%, 56%, 18% and 13% of infants regurgitated at least once a day at 1, 3, 6, 10, and 12 months of age, respectively. Physiological GER affected 53%, 59%, 51%, 16%, and 12% of infants; GERD, 19%, 9%, 5%, 2%, and 2%, respectively. Two risk factors were identified: family history of GER and exposure to passive smoking. Treatment included dietary modification (14%) and pharmacotherapy (5%). Conclusion Physiological GER peaked at 3 months, GERD at 1 month. Most cases resolved on their own. GER and GERD are very common in the infant’s population and parents should be reassured/educated regarding symptoms, warning signs, and generally favorable prognosis. I-GERQ-R is useful to the clinical screening and follow up for GER and GERD.
Transcriptome sequencing and iTRAQ of different rice cultivars provide insight into molecular mechanisms of cold-tolerance response in japonica rice
Authors: Jia Yan , Liu Hualong , Qu Zhaojun , Wang Jin , Wang Xinpeng , Wang Zhuoqian , Yang Liang , Zhang Dong , Zou Detang , Zhao Hongwei 
Published: March 2020

AbstractBackground: Rice ( Oryza sativa L.), one of the most important crops cultivated in both tropical and temperate regions, has a high sensitivity to cold stress. Chilling stress limits N uptake and nitrogen metabolism in rice. To identify the genes and pathways involved in cold tolerance, specifically within the nitrogen metabolism pathway, we compared gene and protein expression differences between a cold-tolerant cultivar, Dongnong428 (DN), and a cold-sensitive cultivar, Songjing10 (SJ). Results: Using isobaric tags for relative or absolute quantification (iTRAQ) with high-throughput mRNA sequencing (RNA-seq) techniques, we identified 5,549 genes and 450 proteins in DN and 6,145 genes and 790 proteins in SJ, that were differentially expressed during low water temperature (T w ) treatment. There were 354 transcription factor (TF) genes (212 down, 142 up), and 366 TF genes (220 down, 146 up), including 47 gene families, differentially expressed in the DN under control (CKDN) vs. DN under low-T w (D15DN) and CKSJ vs. D15SJ, respectively. Genes related to rice cold-related biosynthesis pathways, particularly the mitogen-activated protein kinase (MAPK) signaling pathway, zeatin biosynthesis, and plant hormone signal transduction pathways, were significantly differentially expressed in both rice cultivars. Differentially expressed proteins (DEPs) related to rice cold-related biosynthesis pathways and particularly glutathione metabolism were significantly differentially expressed in both rice cultivars. Transcriptome and proteome analysis of the nitrogen metabolism pathways showed that major genes and proteins that participated in γ-aminobutyric acid (GABA) and glutamine synthesis were downregulated. Conclusion: Under cold stress conditions during reproductive growth, genes and proteins related to the biosynthesis pathways of cold stress were significantly differentially expressed in DN and SJ. The present study confirmed the known cold stress-associated genes and identified a number of putative new cold-responsive genes. We also found that translational regulation under cold stress plays an important role in cold-tolerant DN. Low-T w treatments affected N uptake and N metabolism in rice, and promoted Glu metabolism, and the synthesis of ornithine and proline in cold-sensitive SJ.
Protection of L1 nerve roots by pre-relieve tension in parallel endplate osteotomy for severe rigid thoracolumbar spine deformity
Authors: Liao Hang , Miao Houguang , Xie Peng , Wang Yueyue , Li Ningdao , Zheng Guizhou , Li Xuedong , Du Shixin 
Published: March 2020

Abstract
Background: This is a retrospective study of the use of parallel endplate osteotomy (PEO) for correction of severe rigid thoracolumbar spine deformity.
Methods : From July 2016 to January 2019, 12 patients with severe rigid thoracolumbar spine deformity underwent PEO on T12 or L1 vertebrae were studied.
Results : Following PEO at T12 or L1, the mean kyphosis and scoliosis correction rates reached 77.0 ± 8.9% and 75.5 ± 8.0%, respectively and the intraoperative estimated blood loss was 1950 ± 1050 mL, and the mean operative time was 6.98 ± 4.02 h. The SF-36 scores of physical function, role-physical, bodily pain, general health, vitality, social function, role-emotional and mental health changed from 63 ± 28, 50 ± 25, 50 ± 30, 34 ± 19, 53 ± 28, 45 ± 30, 30 ± 36 and 54 ± 18 at baseline to 83 ± 18, 69 ± 19, 72 ± 12, 66 ± 21, 75 ± 15, 72 ± 22, 66 ± 34 and 76 ± 12 at one year postoperatively , 83 ± 8, 68 ± 32, 83 ± 17, 73 ± 17, 82 ± 18, 76 ± 26, 70 ± 37 and 88 ± 12 at 18 months postoperatively, 86 ± 6, 83 ± 33, 90 ± 16, 81 ± 16, 89 ± 14, 88 ± 25, 83 ± 17 and 94 ± 10 at 24 months postoperatively, respectively (P < 0.01). Three patients had symptoms of L1 nerve root injury, as reflected by lower limb weakness and inner thigh numbness on knee extension and hip flexion, which was further confirmed by electromyography.
Conclusions : PEO is easier to operate, and the spinal cord and nerve root are under direct vision and can effectively and safely correct severe rigid thoracolumbar spine deformity with satisfactory clinical results. However, it is important to identify, separate and protect L1 nerve roots during surgery in cases where patients have symptoms of back pain, muscle weakness and leg numbness on the convex side after surgery.
Key words: Thoracolumbar deformity, Nerve roots injury, L1 nerve roots, Parallel endplate osteotomy
Psychometric Evaluation of Persian Version of the Prenatal Health Behavior Scale
Authors: ghiasvand malihe , Ozgoli Giti , kariman Nourossadat 
Published: March 2020

Abstract
Background: The precise measurement of health promoting and health impairing behavior requires a reliable scale that is specifically designed for the Prenatal behavior. The purpose of the present study was to translate and psychometrically evaluate the Prenatal Health Behavior Scale (PHBS) in Iran.
Methods: The present descriptive study was conducted in 2018. The original version was in English, and was then translated into Persian after obtaining permission from scale designer and using Backward-Forward translation.The final Persian version included 240 pregnant mothers who were selected using random cluster sampling from hospitals affiliated to Shahid Beheshti University of Medical Sciences in Tehran. The factor analysis methods (exploratory and confirmatory), Pearson correlation, and Cronbach's alpha coefficient by SPSSV19 and LISRELV8.80 were used to analyze research findings.
Results: Content validity and face validity were assessed by survey of 10 experts and 20 pregnant mothers.In general, the CVI was 94%.The confirmatory factor analysis indicated that all factor loadings were appropriate and significant in the initial model. Furthermore, coefficient alpha was 0.932 for prenatal health promoting behavior and 0.935 for Health-impairing behaviors. The values were acceptable and indicated the high validity of tool in the Iranian sample.

Conclusion: The research findings indicated that the Prenatal Health Behavior Scale (PHBS) had acceptable psychometric properties among Iranian pregnant women and could be used as a valid scale for assessing prenatal health behavior in Iran.
Gene networks and expression quantitative trait loci associated with platinum-based chemotherapy response in high-grade serous ovarian cancer
Authors: Choi Jihoon , Topouza Danai G. , Tarnouskaya Anastasiya , Nesdoly Sean , Koti Madhuri , Duan Qingling 
Published: March 2020

Abstract
Background A major impediment in the treatment of ovarian cancer is the relapse of platinum-resistant tumors, which occurs in approximately 25% of patients. A better understanding of the biological mechanisms underlying platinum-based chemotherapy response will improve treatment efficacy through genetic testing and novel therapies. Methods Using data from high-grade serous ovarian carcinoma (HGSOC) patients in the Cancer Genome Atlas (TCGA), we classified those who remained progression-free for 12 months following platinum-based chemotherapy as “chemo-sensitive” (N=160) and those who had recurrence within six months as “chemo-resistant” (N=110). Univariate and multivariate analysis of expression microarrays identified a differentially expressed gene and co-expression gene networks associated with chemotherapy response. Moreover, we integrated genomics data to determine expression quantitative trait loci (eQTL). Results Differential expression of the Valosin-containing protein ( VCP ) gene and five co-expression gene networks were significantly associated with chemotherapy response in HGSOC. VCP and the most significant co-expression network module contribute to protein processing in the endoplasmic reticulum, which has been implicated in chemotherapy response. Both univariate and multivariate findings were successfully replicated in an independent ovarian cancer cohort. Furthermore, we identified 192 cis-eQTLs associated with the expression of genes in the co-expression networks and 4 cis-eQTLs associated with BRCA2 expression. Conclusion This study implicates both known and novel genes as well as biological processes underlying response to platinum-based chemotherapy among HGSOC patients.
Diagnostic Test Accuracy of New Generation Tympanic Thermometry in Children under different cutoffs: A Systematic Review and Meta-analysis
Authors: Shi Dan , Zhang Liyuan , Li Haixia 
Published: March 2020

Abstract
Purposes: To identify and quantify studies reporting the diagnostic accuracy of the new generation of infrared tympanic thermometer (IRTT) in children and to compare the sensitivity and specificity of IRTT under different cutoffs and give the optimal cutoff. Methods: Articles were derived from a systematic search in PubMed, Web of Science Core Collection, and Embase, and were assessed for internal validity by the Quality Assessment of Diagnostic Accuracy Studies-2　（QUADAS-Ⅱ）. The figure of risk of bias was created by Review Manager 5.3 and data were synthesized by MetaDisc 1.4. Results: Nineteen diagnostic studies, involving 4,639 pediatric patients, were included. The cut-offs varied from 37.0℃ to 38.0℃ among these studies. The cut-off 37.8℃ was with the highest sROC AUC (0.97) and Youden Index (0.83) and was deemed to be the optimal cutoff. Conclusion: The optimal cutoff for infrared tympanic thermometers is 37.8℃. New Generation Tympanic Thermometry is with high diagnostic accuracy in pediatric patients and can be an alternative for fever screening in children.
Association between NAFLD and risk of prevalent chronic kidney disease: Why there is a difference between East and West?
Authors: Zhang Min , Lin Su , Wang Mingfang , Huang Jiaofeng , Liu Shiying , Wu Sumei , Zhang Haoyang , Wu Zimu , Liu Wenyue , Zhang Dongchu , Hao Chuanming , Zhu Yueyong , Zheng Minghua , Wang Xiaozhong 
Published: March 2020

Abstract
Backgrounds: There is a discrepancy between west and east on the relationship between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). This study aimed to find out the possible reason for this and to clarify the association between NAFLD and CKD by analyzing two population-based datasets from the US and China.
Methods: Two health examination datasets from China and the US were used. CKD was defined as an estimated glomerular filtration rate (eGFR) < 60ml/min/1.73m 2 or and/or abnormal albuminuria and/or overt proteinuria. Binary logistic regression was used to examine the association between NAFLD and CKD.
Results: A total of 60965 participants were analyzed, including 11844 from the US and 51229 from China. The prevalence of NAFLD was 27.12% in the Chinese population and 36.08% in the US population (p<0.001). The proportions of CKD and late stage CKD (stages 3-5) were higher in the US population than the Chinese one. NAFLD was independently associated with an increased risk of CKD in Chinese population, whereas in the US population, the NAFLD was not an independent risk factor of CKD. In subgroup analyses which excluded late stages CKD (stages 3-5), the risks of mild renal function decline became consistent: NAFLD was associated with early stages of CKD but not the late stages of CKD in both populations.
Conclusion: NAFLD increased the risk of early stages of CKD in both Chinese and the US population. The conflicting results reported by previous studies might result from the different proportion of late stages of CKD.
Clinical, Functional and Radiographic Outcomes of Primary Total Hip Arthroplasty between Direct Anterior Approach and Posterior Approach: a Systematic Review and Meta-analysis
Authors: Peng Linbo , Zeng Yi , Wu Yuangang , Zeng Junfeng , Liu Yuan , Shen Bin 
Published: March 2020

Abstract
Background: The purpose of this systematic review and meta-analysis was to compare the direct anterior approach and posterior approach for primary total hip arthroplasty in terms of the clinical, functional and radiographic outcomes.

Methods: We searched the PubMed and EMBASE databases and Cochrane Library from their inception to November 1, 2019. We searched for previously published articles and meta-analyses of randomized controlled trials.

Results: A total of 7 randomized controlled trials with 600 participants met the inclusion criteria. Among these patients, 301 and 299 were included in the DAA and PA groups, respectively. The DAA was associated with a longer surgery by a mean duration of 13.74 min (95% CI 6.88 to 20.61, p < 0.0001, I 2 =93%). The postoperative early functional outcomes were significantly better in the DAA group than in the PA group, such as the Visual Analogue Scale (VAS) score at 1 day postoperatively (MD=-0.65, 95% CI -0.91 to -0.38, p < 0.00001, I 2 =0%), VAS score at 2 days postoperatively (MD=-0.67, 95% CI -1.34 to -0.01, p =0.05, I 2 =88%) and Harris Hip Score (HHS) at 6 weeks postoperatively (MD=6.05, 95% CI 1.14 to 10.95, p =0.02, I 2 =52%). There was no significant difference between the DAA and PA groups in the length of the incision, hospital length of stay (LOS), blood loss, transfusion rates or complication rates. We found no significant difference between the two groups regarding late functional outcomes, such as the VAS score at 12 months postoperatively or the HHS scores at 3, 6, and 12 months postoperatively. A significant difference in the radiographic outcomes was not detected.

Conclusions: The DAA requires a longer surgery time than does the PA in primary total hip arthroplasty. The DAA yields better early functional recovery than does the PA. There was no significant difference between the two groups in terms of other clinical, complication-related, late functional or radiographic outcomes. The evidence on the superiority of the DAA is insufficient and needs to be studied further.
The predictive value of lncRNA MIR31HG expression on clinical outcomes in patients with solid malignant tumors
Authors: Tu Chao , Ren Xiaolei , He Jieyu , Li Shuangqing , Qi Lin , Duan Zhixi , Wang Wanchun , Li Zhihong 
Published: March 2020

Abstract
Background Emerging studies have explored the prognostic value of MIR31HG in cancers, but its role remains elusive. Herein, we aimed to summarize the prognostic potential of MIR31HG in this study. Methods Several databases were searched for literature retrieval on Dec 5, 2019. Overall and subgroup analyses were conducted to measure the relationship between MIR31HG expression and clinical outcomes. Moreover, GEPIA was applied for validation of prognostic value of MIR31HG in tumor patients in TCGA dataset. Results Overall, seventeen studies with 2,573 patients were enrolled. Compared to counterparts, those patients with high MIR31HG expression tended to have shorter RFS. Notably, MIR31HG overexpression predicted unfavorable OS in lung cancer. By contrast, gastrointestinal cancer patients with elevated MIR31HG expression predicted better OS and disease-free survival. Additionally, MIR31HG overexpression was significantly associated with worse clinicopathological features including advanced tumor stage and LNM in lung cancer, but favorable clinical characteristics in gastrointestinal cancer. Moreover, the positive association between MIR31HG and OS in lung cancer was further confirmed in TCGA dataset. Conclusion Overexpression of MIR31HG suggested remarkable association with poor prognosis in terms of OS, tumor stage, and LNM in lung cancer, but favorable prognosis in gastrointestinal cancer. Therefore, MIR31HG may serve as a promising prognostic biomarker in multiple cancers.
Diabetes Mellitus Accelerates Progression of Osteoarthritis in Streptozotocin-induced Diabetic Mice by Deteriorating Bone Microarchitecture, Bone Mineral Composition and Bone Strength of Subchondral Bone
Authors: Wang Hua-Jun , Giambini Hugo , Liu You-Jie , Chen Ji-Wen , Wang Qiu-Shi , Hou Hui-ge , Luo Si-Min , Chen Jun-Yuan , Zhuang Teng-Feng , Chen Yuan-Feng , Wu Ting-Ting , Zha Zhen-gang , Zheng Xiaofei 
Published: March 2020

Abstract
The authors have withdrawn this preprint from Research Square
Does electronic consent improve the logistics and uptake of hpv vaccination in adolescent girls? A mixed methods theory informed evaluation of an intervention
Authors: Chantler Tracey , Pringle Ellen , Bell Sadie , Cooper Rosie , Edmundson Emily , Nielsen Heidi , Roberts Sheila , Edelstein Michael , Jack Sandra Mounier 
Published: March 2020

Abstract
The authors have withdrawn this preprint from Research Square
Leishmania infantum and Dirofilaria immitis infections in Italy, 2009-2019: changing distribution patterns
Authors: Mendoza-Roldan Jairo , Benelli Giovanni , Panarese Rossella , Iatta Roberta , Furlanello Tommaso , Beugnet Frederic , Zatelli Andrea , Otranto Domenico 
Published: March 2020

Abstract
Background: For long time, canine leishmaniosis (CanL) was considered endemic in the southern, central, and insular regions of Italy, whereas heartworm disease (HW) by Dirofilaria immitis in the northern region and in the swampy Po valley. Following the reports of new foci of both diseases, in this study we update the distribution patterns and occurrence of new foci of CanL and HW discussing the main drivers for the changes in the epidemiology of these two important zoonotic canine vector-borne diseases. Methods: Based on the statistical analyses of serological assays (n=90,633) on L. infantum exposure and D. immitisinfection performed by reference diagnostic centres in Italy over a ten-year period (2009–2019), the distribution patterns of both pathogens were herein presented along with the occurrence of new foci. Results: Results highlighted the changing distribution patterns of L. infantum vs D. immitis infection in Italy. CanL is now endemic also in the northern regions and HW has endemic foci in central and southern regions and islands.Significant differences in L. infantum exposure and HW infection prevalence among the study macroareas were detected. The overall prevalence of L. infantum exposure was 28.2% in southern Italy and Islands, 29.6% in central Italy and 21.6% in northern Italy and that of HW of 2.83% in northern Italy, 7.75% in central Italy and 4.97% in southern Italy and islands. HW prevalence significantly varied over years (χ2=108.401, d.f.=10, p<0.0001), gradually increasing from 0.77% in 2009 to 8.47% in 2016-2017. Conclusions: The new epidemiological scenarios have been discussed according to a range of factors (e.g. environmental modifications, occurrence of competent insect vectors, transportation of infected animals to non-endemic areas, chemoprophylaxis or vector preventative measures), which may affect the current distribution. Overall, results advocate for epidemiological surveillance programs, more focussed preventative and control measures even in areas where few or none cases of both diseases have been diagnosed.