bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of maternal nutrient restriction and day of early pregnancy on the location and abundance of neutral amino acid transporters in beef heifer utero-placental tissues
Authors: Crouse Matthew S , McLean Kyle J , Greseth Nathaniel P , Ward Alison K , Reynolds Lawrence P , Dahlen Carl R , Neville Bryan W , Borowicz Pawel P , Caton Joel S 
Published: June 2020

Abstract
We hypothesized that maternal nutrition and day of gestation would influence the abundance of the neutral amino acid transporters SLC1A1, SLC1A5, SLC7A5, SLC38A2, and SLC38A7 in heifer utero-placental tissues. Angus-cross heifers (n = 43) were estrus synchronized and bred via AI. At breeding, heifers were assigned to one of two dietary intake groups (CON = 100% of requirements to achieve 0.45 kg/d gain or restricted heifers (RES) = 60% of CON intake) and ovariohysterectomized on day 16, 34, or 50 of gestation (n = 6 to 9/d). Thus, the experimental design was a completely randomized design with a 2 × 3 factorial arrangement of treatments. Uterine cross sections were taken from the horn ipsilateral to the CL, fixed in 10% NBF, sectioned at 5 µm, and stained for transporters. For each image, the areas of fetal membrane (FM; chorioallantois), endometrium (ENDO), superficial glands (SG), deep glands (DG), and myometrium (MYO) were analyzed separately for relative intensity of fluorescence as an indicator of transporter abundance. Analysis of FM was only conducted on days 34 and 50. In ENDO, SLC7A5 was greater (P &lt; 0.01) in CON compared with RES heifers. In SG, SLC1A1 was greater (P = 0.02) in day 16 RES compared with day 16 CON and days 34 and 50 RES. In DG, SLC1A1 was greater (P = 0.02) on day 16 compared with 50 of gestation. In MYO, SLC1A1 was greater (P = 0.02) in day 50 CON compared with day 16 CON and day 50 RES. Additionally, in MYO SLC38A2 was greater (P = 0.02) in day 16 RES compared with day 16 CON and day 34 RES. In FM, SLC7A5 tended (P = 0.08) to be greater in CON vs RES. Analysis of all uterine tissues on day 16 determined that expression of SLC1A1, SLC1A5, SL38A2, and SL38A7 differed across uterine tissue type (P &lt; 0.01); however, only SLC7A5 tended (P = 0.10) to differ and be greater in CON compared with RES heifers. Analysis of all utero-placental tissues on days 34 and 50 determined that SLC1A1, SLC7A5, SLC38A2, and SLC38A7 were greater (P ≤ 0.03) in CON compared with RES heifers. Furthermore, abundance of all transporters investigated on days 34 and 50 differed across utero-placental tissue types (P &lt; 0.01). These data support our hypothesis that maternal nutrition and day of gestation influence the abundance of neutral amino acid transporters in utero-placental tissues from days 16 to 50 of gestation. Additionally, these data combined with previously published works help further elucidate nutrient supply and demands of the maternal and fetal system during early gestation in beef heifers.
Evaluation of a direct age estimation method for terminally molted male snow crab Chionoecetes opilio (Fabricius 1788) (Decapoda: Brachyura: Oregoniidae)
Authors: Rebert April L , Kruse Gordon H , Webb Joel B , Tamone Sherry L , Oxman Dion , McNeel Kevin W 
Published: June 2020

Abstract
Recent research suggests that calcified eyestalks and gastric mill ossicles (stomach teeth) can be used to estimate the age of some crustacean species. Along with annual growth of the endocuticle, bipartite bands in the hard tissue are believed to reflect annual growth patterns (similar to fish scales or otoliths) that are retained through repeated molt cycles. Similar bands are observed in the zygocardiac ossicles of the gastric mill from the snow crab (Chionoecetes opilioFabricius 1788). If these bands reflect annual growth, they may be used to estimate age, which could enhance understanding growth, mortality, recruitment, and age composition and improve fishery management. While some studies show that the number of bands correlates to other estimates of age for C. opilio, little evidence suggests that bands accumulate annually as growth increments independent of molting. Male C. opilio terminally molt at maturity, after which they can survive for seven years or more. Shell condition, i.e., degree of wear and epibionts on their exoskeleton, is used here and by other carcinologists as a proxy for age subsequent to the terminal molt. We estimated band counts and endocuticle thickness from thin sections of the zygocardiac ossicle of terminally molted male C. opilio across a range of shell conditions from a wild, fished stock. We found no differences in band counts (P = 0.41) or endocuticle thickness (P = 0.13) across varying shell conditions and size. These results do not support the hypothesis that band counts can be used to estimate the age of this species after the terminal molt.
Preference Refinement after a Budget Contraction
Authors: Ross Gretchen R , Meloy Margaret G , Carlson Kurt A 
Published: June 2020

Abstract
How does coping with a resource loss of time, space, or money change a consumer? In the current work, we argue that resource losses that give rise to budget contractions require a coping strategy that not only influences choice in the moment but also changes underlying consumer preferences. We show that the preference restructuring that occurs when coping with a budget loss also leads to stabilization of preferences. Specifically, a consumer who allocates a budget to a set of items prior to a budget contraction and allocates that same budget post-contraction when the budget is fully restored will allocate the restored budget to fewer options in the set. Coping with the contraction helps consumers prioritize what matters to them, leading to refinement of preference. This within-consumer preference refinement effect exists for budgets of time, space, and money. We identify boundary conditions (i.e., significant budget contractions and self-determined contraction allocations are necessary for prioritization to occur) and rule out non-prioritization explanations (e.g., anchoring and under-adjusting). These findings suggest that marketers should focus on capturing consumers who are dealing with budget contractions as this is one of the moments where individuals revisit and rediscover what matters most to them.
Setting priorities fairly in response to Covid-19: identifying overlapping consensus and reasonable disagreement
Authors: Wasserman David , Persad Govind , Millum Joseph 
Published: June 2020

Abstract
Proposals for allocating scarce lifesaving resources in the face of the Covid-19 pandemic have aligned in some ways and conflicted in others. This paper attempts a kind of priority setting in addressing these conflicts. In the first part, we identify points on which we do not believe that reasonable people should differ—even if they do. These are (i) the inadequacy of traditional clinical ethics to address priority-setting in a pandemic; (ii) the relevance of saving lives; (iii) the flaws of first-come, first-served allocation; (iv) the relevance of post-episode survival; (v) the difference between age and other factors that affect life-expectancy; and (vi) the need to avoid quality-of-life judgments. In the second part, we lay out some positions on which reasonable people can and do differ. These include (i) conflicts between maximizing benefits and priority to the worst off; (ii) role-based priority; and (iii) whether patients’ existing lifesaving resources should be subject to redistribution.
Prescription Psychoactive Medication Use in Adolescent Survivors of Childhood Cancer and Association With Adult Functional Outcomes
Authors: Cheung Yin Ting , Liu Wei , Brinkman Tara M , Srivastava Deokumar , Leisenring Wendy M , Howell Rebecca M , Ullrich Nicole J , Lommel Karen M , Brouwers Pim , Gibson Todd M , Robison Leslie L , Armstrong Gregory T , Krull Kevin R 
Published: June 2020

Abstract

Background
This study estimates the prevalence and identifies predictors of psychoactive medication use in adolescent survivors of childhood cancer (aged 12-18 years) and its associations with functional outcomes at young adulthood (aged 18-28 years).

Methods
This retrospective cohort study includes 5665 adolescent survivors of childhood cancer at no less than 5 years postdiagnosis (53.8% male, median age = 15 years, interquartile range [IQR] = 13-16 years) and 921 adolescent sibling controls. Parent-reported psychoactive medication use during adolescence was collected at baseline. After a median of 8 years, functional outcomes and social attainment were self-reported during adulthood (n = 3114, median age = 22 years, IQR = 20-24 years). Multivariable log-binomial models evaluated associations among risk factors, medication use, and adult outcomes.

Results
Higher prevalence of psychoactive medication use was reported in survivors compared with siblings (18.3% vs 6.6%; 2-sided P &lt; .001), with trends for increasing antidepressant and stimulant use in recent treatment eras. After adjusting for cancer treatment and baseline cognitive problems, psychoactive medication use during adolescence was associated with impaired task efficiency (relative risk [RR] = 1.20, 95% confidence interval [CI] = 1.01 to 1.43) and memory (RR = 1.27, 95% CI = 1.05 to 1.52) during adulthood. Survivors who reported continued use of medications from adolescence to adulthood demonstrated poorer emotional regulation (RR = 1.68, 95% CI = 1.24 to 2.27) and organization (RR = 1.82, 95% CI = 1.28 to 2.59) compared with nonusers. Adolescent opioid use was associated with somatization symptoms (RR = 1.72, 95% CI = 1.09 to 2.73) during adulthood, after adjusting for cancer treatment and baseline behavioral problems. They were also more likely to not complete college (RR = 1.21, 95% CI = 1.04 to 1.41) or work full-time (RR = 1.60, 95% CI = 1.23 to 2.08) compared with nonusers.

Conclusion
Use of psychoactive medication is more prevalent among adolescent survivors compared with siblings and does not normalize adult outcomes, as evidenced by poorer functional outcomes during young adulthood.
Metastatic pleural mesothelioma presenting initially as multiple gastric and colonic polyps
Authors: Alhumidi Ahmed , Alqahtani Abdulmalik 
Published: June 2020

Abstract
It is extremely rare for malignant mesothelioma to present as gastrointestinal polyps. This case report documents the presentation of malignant mesothelioma in a 72-year-old as rectal bleeding and weight loss. Endoscopically, there were multiple gastric and colonic polyps. Histopathologically, there were atypical cells in the lamina propria with benign surface epithelium. The cells tested positive for cytokeratin, calretinin and D2–40 and negative for CD45, CD117, Ber-EP4 and CEA, confirming the diagnosis of metastatic mesothelioma. A computed tomography scan of the chest showed nodular thickening of the left lower pleura that was compatible with a diagnosis of primary pleural mesothelioma. We conclude that metastatic mesothelioma can sometimes present as gastrointestinal polyps.
Centres and Peripheries: Early-Modern British Writers in a European Context
Authors: Stevenson Jane 
Published: June 2020

Abstract
The ESTC has privileged a view of Britain's early print culture focused on London, while making it hard to look at British contributions to continental print cultures. But there were readers in early-modern Britain who were acculturated elsewhere. Scots bought most of their books on the continent, preferring Latin or French to English, and published on the continent, bypassing London. In Britain as a whole, there are effectively three centres for British print culture, London, ‘Rome’ and ‘Geneva’. The Netherlands printed for the English market, notably illicit bibles with Geneva notes, and particularly successful books were often issued there in Dutch or French, while British writers in Latin fed into continental literary fashions. Take-up of English literature as such was limited, partly because the Dutch did not admire English poetics. Most of what the Dutch translated from English was political or religious. Some English protestant writers were massively successful in translation, but translation into Dutch was almost always a first step from which their work was disseminated.
Aperture shapes and the effectiveness of ground-based large and extremely large telescopes
Authors: Hakobyan Armen V 
Published: June 2020

ABSTRACT
Aperture shapes in modern large and forthcoming extremely large telescopes (ELTs), with effective light-gathering sizes more than D ∼ 10 m, differ significantly from the desirable circular one. They deliver specific point spread functions, which may also differ notably from that of the fine structure of the classical Airy pattern. The optical power of such a telescope can be changed notably compared with a circular aperture with the same area. The presence of atmospheric optical turbulence complicates the effect additionally and makes it seeing- and wavelength-dependent. So, what is the impact of a non-circular pupil on telescope exploitation? It concerns the efficiency, which is an important point, especially for instruments of such a class. In this research an attempt is made to assess the values of these changes in the context of the Keck, HDRT, GMT, TMT and ELT telescopes. Relative performance characteristics (integral contrast and signal-to-noise ratio, S/N) of the telescopes, working in the seeing-limited regime, under a range of plausible turbulence conditions, for a wide (from UV to mid-IR) spectral region are obtained. The partial role of central obscuration is assessed. The effect of adaptive optics implementation in this context is also analysed. It is shown that, for instance, maximal S/N degradation due to the non-circularity of the pupil shape can be as much as $\sim 6~{{\ \rm per\ cent}}$ (TMT) to $30~{{\ \rm per\ cent}}$ (HDRT), depending on the telescope and observational mode. The numbers are comparable with or may even substantially exceed the losses that could be caused by the other parameters (e.g. residual wave-front error, optical transmittance) relevant to the quality of the optical system.
Application of a helicity proxy to edge-on galaxies
Authors: Brandenburg Axel , Furuya Ray S 
Published: June 2020

ABSTRACTWe study the prospects of detecting magnetic helicity in galaxies by observing the dust polarization of the edge-on galaxy NGC 891. Our numerical results of mean-field dynamo calculations show that there should be a large-scale component of the rotationally invariant parity-odd B polarization that we predict to be negative in the first and third quadrants, and positive in the second and fourth quadrants. The large-scale parity-even E polarization is predicted to be negative near the axis and positive further away in the outskirts. These properties are shown to be mostly a consequence of the magnetic field being azimuthal and the polarized intensity being maximum at the centre of the galaxy and are not a signature of magnetic helicity.
Rph1 coordinates transcription of ribosomal protein genes and ribosomal RNAs to control cell growth under nutrient stress conditions
Authors: Shu Wen-Jie , Chen Runfa , Yin Zhao-Hong , Li Feng , Zhang Heng , Du Hai-Ning 
Published: June 2020

Abstract
Coordinated regulation of ribosomal RNA (rRNA) synthesis and ribosomal protein gene (RPG) transcription by eukaryotic RNA polymerases (RNAP) is a key requirement for growth control. Although evidence for balance between RNPI-dependent 35S rRNA production and RNAPII-mediated RPG transcription have been described, the molecular basis is still obscure. Here, we found that Rph1 modulates the transcription status of both rRNAs and RPGs in yeast. We show that Rph1 widely associates with RNAPI and RNAPII-transcribed genes. Deletion of RPH1 remarkably alleviates cell slow growth caused by TORC1 inhibition via derepression of rRNA and RPG transcription under nutrient stress conditions. Mechanistically, Rim15 kinase phosphorylates Rph1 upon rapamycin treatment. Phosphorylation-mimetic mutant of Rph1 exhibited more resistance to rapamycin treatment, decreased association with ribosome-related genes, and faster cell growth compared to the wild-type, indicating that Rph1 dissociation from chromatin ensures cell survival upon nutrient stress. Our results uncover the role of Rph1 in coordination of RNA polymerases-mediated transcription to control cell growth under nutrient stress conditions.
Antiviral Activity and Safety of Darunavir/Cobicistat for the Treatment of COVID-19
Authors: Chen Jun , Xia Lu , Liu Li , Xu Qingnian , Ling Yun , Huang Dan , Huang Wei , Song Shuli , Xu Shuibao , Shen Yingzhong , Lu Hongzhou 
Published: June 2020

Abstract

Background
We aimed to evaluate the antiviral activity and safety of darunavir/cobicistat (DRV/c) in treating COVID-19 patients.

Methods
In this single-center, randomized, and open-label trial, mild patients with polymerase chain reaction (PCR)–confirmed COVID-19 were enrolled in Shanghai, China. Participants were randomized to receive DRV/c for 5 days on the top of interferon alpha 2b inhaling or interferon alpha 2b inhaling alone. The primary end point was the virological clearance rate of oropharyngeal swabs at day 7 after randomization in the intention-to-treat population (clinicaltrials.gov: NCT04252274).

Results
From January 30, 2020, to February 6, 2020, a total of 30 patients were enrolled, of whom 18 (60%) were male, aged 47.2 ± 2.8 years; 63.3% (19/30) of the participants had fever, and 46.7% (14/30) had cough at enrollment. The participants were randomized (range) at 4 (2–5) days after onset of symptoms. The proportion of negative PCR results at day 7 was 46.7% (7/15) and 60.0% (9/15) in the DRV/c and control groups (P = .72), respectively. The viral clearance rate at day 3 was 20% (3/15) in both study groups, while the number increased to 26.7% (4/15) in the DRV/c group and remained 20% (3/15) in the control group at day 5. Fourteen days after randomization, 1 participant in the DRV/c group progressed to critical illness and discontinued DRV/c, while all the patients in the control group were stable (P = 1.0). The frequencies of adverse events in the 2 groups were comparable.

Conclusions
Five days of DRV/c did not increase the proportion of negative conversion vs standard of care alone, although it was well tolerated.
International cooperation during the COVID-19 pandemic
Authors: Brown Gordon , Susskind Daniel 
Published: June 2020

AbstractThis paper explores the concept of ‘global public goods’ (GPGs) in the context of the ongoing COVID-19 pandemic. It argues that many of the tasks involved in public health, and in particular those involved in the control of an infectious disease like COVID-19, ought to be treated as GPGs that can only be effectively delivered through international cooperation. It sets out what a cooperative response to the COVID-19 pandemic should look like and introduces ideas for further discussion about how it might be financed.
Urban Borderlines: Negotiating Spatial, Social, and Symbolic Boundaries in Urban Contexts
Authors: Jalili Jaleh 
Published: June 2020

AbstractSociological research has productively engaged with boundary processes in urban contexts, but few studies explore the relation between space and social and symbolic boundaries. Based on fieldwork in Tehran, Iran, and building on literature on boundary processes, I incorporate a spatial approach into the discussion of social and symbolic boundaries. The focus is on city-level public spaces that function beyond neighborhoods and draw people from outside the immediate community. This article expands the discussion of boundaries beyond particular neighborhoods by situating social relations in the broader context of the metropolitan area. In Tehran, urban developments have increased mobility in use of public spaces, particularly enabling the less privileged in the south to move more easily and use spaces in the north, resulting in a fairly mixed social landscape. Using observations, survey data, and interviews with users of public spaces, I study the related social consequences and explore how boundaries are perceived and negotiated in changing urban environments. The findings shed light on some of the processes through which social and symbolic boundaries are questioned or maintained, as spatial boundaries become more fluid, blurred, and negotiable in a more accessible city.
Plasma-induced catalysis: towards a numerical approach
Authors: Li Haijing , Toschi Federico 
Published: June 2020

A lattice Boltzmann (LB) model is developed, validated and used to study simplified plasma/flow problems in complex geometries. This approach solves a combined set of equations, namely the Navier–Stokes equations for the momentum field, the advection–diffusion and the Nernst–Planck equations for electrokinetic and the Poisson equation for the electric field. This model allows us to study the dynamical interaction of the fluid/plasma density, velocity, concentration and electric field. In this work, we discuss several test cases for our numerical model and use it to study a simplified plasma fluid flowing and reacting inside a packed bed reactor. Inside the packed bed, electric breakdown reactions take place due to the electric field, making neutral species ionize. The presence of the packed beads can help enhance the reaction efficiency by locally increasing the electric field, and the size of packed beads and the pressure drop of the packed bed do influence the outflux. Hence trade-offs exist between reaction efficiency and packing porosity, the size of packing beads and the pressure drop of the packed bed. Our model may be used as a guidance to achieve higher reaction efficiencies by optimizing the relevant parameters.This article is part of the theme issue ‘Fluid dynamics, soft matter and complex systems: recent results and new methods’.
Dynamics and fragmentation of small inextensible fibres in turbulence
Authors: Allende Sofía , Henry Christophe , Bec Jérémie 
Published: June 2020

The fragmentation of small, brittle, flexible, inextensible fibres is investigated in a fully developed, homogeneous, isotropic turbulent flow. Such small fibres spend most of their time fully stretched and their dynamics follows that of stiff rods. They can then break through tensile failure, i.e. when the tension is higher than a given threshold. Fibres bend when experiencing a strong compression. During these rare and intermittent buckling events, they can break under flexural failure, i.e. when the curvature exceeds a threshold. Fine-scale massive simulations of both the fluid flow and the fibre dynamics are performed to provide statistics on these two fragmentation processes. This gives ingredients for the development of accurate macroscopic models, namely the fragmentation rate and daughter-size distributions, which can be used to predict the time evolution of the fibre size distribution. Evidence is provided for the generic nature of turbulent fragmentation and of the resulting population dynamics. It is indeed shown that the statistics of break-up is fully determined by the probability distribution of Lagrangian fluid velocity gradients. This approach singles out that the only relevant dimensionless parameter is a local flexibility which balances flow stretching to the fibre elastic forces.
This article is part of the theme issue ‘Fluid dynamics, soft matter and complex systems: recent results and new methods’.