bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability, measurement error and minimum detectable change in mobility measures: a cohort study of community-dwelling adults aged 50 years and over in Ireland
Authors: Donoghue Orna A , Savva George M , Börsch-Supan Axel , Kenny Rose Anne 
Published: November 2019

ObjectiveTo estimate the effects of repeat assessments, rater and time of day on mobility measures and to estimate their variation between and within participants in a population-based sample of Irish adults aged ≥50 years.DesignTest–retest study in a population representative sample.SettingAcademic health assessment centre of The Irish Longitudinal Study on Ageing (TILDA).Participants128 community-dwelling adults from the Survey for Health, Ageing and Retirement in Europe (SHARE) Ireland study who agreed to take part in the SHARE-Ireland/TILDA collaboration.InterventionsNot applicable.Outcome measuresParticipants performed timed up-and-go (TUG), repeated chair stands (RCS) and walking speed tests administered by one of two raters. Repeat assessments were conducted 1–4 months later. Participants were randomised with respect to a change in time (morning, afternoon) and whether the rater was changed between assessments. Within and between-participant variance for each measure was estimated using mixed-effects models. Intraclass correlation (ICC), SE of measurement and minimum detectable change (MDC) were reported.ResultsAverage performance did not vary between baseline and repeat assessments in any test, except RCS. The rater significantly affected performance on all tests except one, but time of day did not. Reliability varied from ICC=0.66 (RCS) to ICC=0.88 (usual gait speed). MDC was 2.08 s for TUG, 4.52 s for RCS and ranged from 19.49 to 34.73 cm/s for walking speed tests. There was no evidence for lower reliability of gait parameters with increasing time between assessments.ConclusionsReliability varied for each test when measurements are obtained over 1–4 months with most variation due to rater effects. Usual and motor dual task gait speed demonstrated highest reliability.
Hospital-based cohort study to determine the association between home-time and disability after stroke by age, sex, stroke type and study year in Canada
Authors: Yu Amy Ying Xin , Fang Jiming , Porter Joan , Austin Peter C , Smith Eric E , Kapral Moira K 
Published: November 2019

ObjectiveHome-time is an emerging patient-centred stroke outcome metric, but it is not well described in the population. We aimed to determine the association between 90-day home-time and global disability after stroke. We hypothesised that longer home-time would be associated with less disability.DesignHospital-based cohort study of patients with ischaemic stroke or intracerebral haemorrhage admitted to an acute care hospital between 1 April 2002 and 31 March 2013.SettingAll regional stroke centres and a simple random sample of patients from all other hospitals across the province of Ontario, Canada.ParticipantsWe included 39 417 adult patients (84% ischaemic, 16% haemorrhage), 53% male, with a median age of 74 years. We excluded non-residents of Ontario, patients without a valid health insurance number, patients discharged against medical advice or those who failed to return from a pass, patients living in a long-term care centre at baseline and stroke events occurring in-hospital.Primary outcome measureAssociation between 90-day home-time, defined as the number of days spent at home in the first 90 days after stroke, obtained using linked administrative data and modified Rankin Scale score at discharge.ResultsCompared with people with no disability, those with minimal disability had less home-time (adjusted rate ratio (aRR) 0.96, 95% CI 0.93 to 0.98) and those with the most severe disability had the least home-time (aRR 0.05, 95% CI 0.04 to 0.05). We found no clinically relevant modification by stroke type, sex or study year. However, for a given level of disability, older patients experienced less home-time compared with younger patients.ConclusionsOur results provide content validity for home-time to be used to monitor stroke outcomes in large populations or to study temporal trends. Older patients experience less home-time for a given level of disability, suggesting the need for stratification by age.
Time intervals experienced between first symptom recognition and pathologic diagnosis of breast cancer in Addis Ababa, Ethiopia: a cross-sectional study
Authors: Gebremariam Alem , Addissie Adamu , Worku Alemayehu , Assefa Mathewos , Pace Lydia E , Kantelhardt Eva Johanna , Jemal Ahmedin 
Published: November 2019

ObjectivesThis study aimed to estimate the magnitude of patient and diagnostic delays and associated factors among women with breast cancer in Addis Ababa.DesignThis is a cross-sectional study.Settings and participantsAll women newly diagnosed with breast cancer in seven major healthcare facilities in Addis Ababa (n=441) were included in the study.Main outcomes and measuresPatient interval (time from recognition of first symptom to medical consultation) and diagnostic interval (time from first consultation to diagnosis). Patient intervals >90 days and diagnostic intervals >30 days were considered delays, and associated factors were determined using multivariable Poisson regressions with robust variance.ResultsThirty-six percent (95% CI [31.1%, 40.3%]) of the patients had patient intervals of >90 days, and 69% (95% CI [64.6%, 73.3%]) of the patients had diagnostic intervals of >30 days. Diagnostic interval exceeded 1 year for 18% of patients. Ninety-five percent of the patients detected the first symptoms of breast cancer by themselves, with breast lump (78.0%) as the most common first symptom. Only 8.0% were concerned about cancer initially, with most attributing their symptoms to other factors. In the multivariable analysis, using traditional medicine before consultation was significantly associated with increased prevalence of patient delay (adjusted prevalence ratio (PR) = 2.13, 95% CI [1.68, 2.71]). First consultation at health centres (adjusted PR = 1.19, 95% CI [1.02, 1.39]) and visiting ≥4 facilities (adjusted PR = 1.24, 95% CI [1.10, 1.40]) were associated with higher prevalence of diagnostic delay. However, progression of symptoms before consultation (adjusted PR = 0.73, 95% CI [0.60, 0.90]) was associated with decreased prevalence of diagnostic delay.ConclusionsPatients with breast cancer in Addis Ababa have prolonged patient and diagnostic intervals. These underscore the need for public health programme to increase knowledge about breast cancer symptoms and the importance of early presentation and early diagnosis among the general public and healthcare providers.
Examining satisfaction of older adult patients and their caregivers following traumatic injury: a cross-sectional study of three level I trauma centres
Authors: Vogel Rebecca , McGraw Constance , Orlando Alessandro , Bourg Pamela , Dreiman Chester , Peck Laura , Tanner Allen , Lynch Neal , Bar-Or David 
Published: November 2019

ObjectiveTo explore satisfaction of care received by older adult patients and their primary caregivers following traumatic injury.DesignProspective, cross-sectional study using the FAMCARE (Family Satisfaction with Advanced Cancer Care Scale) satisfaction surveys prior to discharge.SettingThree level I trauma centres in Colorado from November 2016 to December 2017.ParticipantsTrauma patients ≥55 years old and their primary caregivers.Outcome measuresOverall mean (SD) satisfaction, satisfaction <80% vs ≥80%, and mean satisfaction by survey conceptual structures.ResultsOf the 319 patients and 336 caregivers included, the overall mean (SD) patient satisfaction was 81.7% (15.0%) and for caregivers was 83.6% (13.4%). The area with the highest mean for patient and caregiver satisfaction was psychosocial care (85.4% and 86.9%, respectively). Information giving was the lowest for patients (80.4%) and caregivers (80.9%). When individual items were examined, patients were significantly more satisfied with ‘availability of nurses to answer questions’ (84.5 (15.3) vs 87.4 (14.8), p=0.02) and significantly less satisfied with ‘speed with which symptoms were treated’ (80.6 (17.9) vs 84.0 (17.0), p=0.03) compared with caregivers. Patients with a history of smoking (least squares mean difference: −0.096 (−0.18 to –0.07), p<0.001) and hospital discharge destination to an outside facility of care (adjusted OR: 1.6 (1.0 to 2.4), p=0.048) were identified as independent predictors of lower overall satisfaction in generalised linear and logistic models, respectively.ConclusionsOur data suggest that patients’ medical history was driving both patient and caregiver satisfaction. Patient characteristics and expectations need to be considered when tailoring healthcare interventions.
Interventions for pregnant women who use tobacco and other substances: a systematic review protocol
Authors: Jackson Melissa A , Baker Amanda L , McCarter Kristen L , Brown Amanda L , Gould Gillian S , Dunlop Adrian J 
Published: November 2019

IntroductionThe prevalence of tobacco smoking in pregnancy remains elevated in some disadvantaged populations of women. One group is those who use alcohol and/or other psychoactive substances during pregnancy, with tobacco use prevalence estimates ranging from 71% to 95%. Although effective evidence-based cessation treatments exist, few women with co-occurring substance use problems successfully stop smoking during pregnancy. There is limited information about treatments that specifically target this group and a summary of the available research is required to assist and enhance the development of innovative cessation interventions. This article describes a protocol for a comprehensive review of studies that have trialled behavioural and/or pharmacological tobacco cessation interventions in populations of pregnant women who are nicotine dependent and use alcohol and/or other psychoactive substances.Methods and analysisThe review will undertake literature searches in MEDLINE, PsycINFO, CINAHL, EMBASE and ProQuest databases, as well as the grey literature. Studies of any design methodology will be included if they describe changes to tobacco smoking behaviours in quantitative terms. No restriction on year of publication or published language will apply. Participants include pregnant women of any age, who smoke tobacco, who are seeking or having treatment, or in post-treatment recovery for the use of psychoactive substances. Interventions are any psychological, behavioural or pharmacological treatments used to treat tobacco use. Outcome measures are any that quantitatively report abstinence or reductions in participant tobacco consumption. Key details and tobacco-related outcomes from included studies will be extracted and tabulated before being narratively synthesised. The systematic review protocol has been developed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines.Ethics and disseminationEthics approval is not required. Findings will be disseminated via peer-reviewed literature, conference presentations, media and social media.PROSPERO registration numberCRD42018108777
Immunohistochemistry for the detection of BRCA1 and BRCA2 proteins in patients with ovarian cancer: a systematic review
Authors: Teixeira Lorena Alves , Candido dos Reis Francisco Jose 
Published: November 2019

BackgroundLoss of function in either breast cancer type 1 susceptibility protein (BRCA1) or breast cancer type 2 susceptibility protein (BRCA2) is a major risk factor for epithelial ovarian cancer (EOC) development. BRCA1 or BRCA2 deficiencies are associated with short-term prognosis and might have importance for the treatment of women with the disease. However, the screening of all possible mechanisms of dysfunction is expensive, time-consuming and difficult to apply in clinical practice. On the other hand, immunohistochemistry (IHC) is a simple and reliable method to access the expression of several proteins in tumour tissues.Materials and methodsThis systematic review aims to evaluate the current usage of IHC to detect BRCA1 and BRCA2 deficiencies in EOC. We searched and evaluated all primary literature on the use of IHC for evaluating BRCA1 and BRCA2 proteins expression in EOC. The main concepts for the search were: ovarian neoplasms, IHC, BRCA1 and BRCA2.ResultsForty-four studies from 925 unique titles were included. A total of 4206 tumour samples were evaluated for BRCA1 and 1041 for BRCA2 expression. Twelve BRCA1 primary antibodies were used in 41 studies, and the most common was the MS110 clone (75.6%). Seven BRCA2 primary antibodies were used in ten studies. Using the cut-off of 10%, 47.0% of EOCs are associated with loss of BRCA1 and 34.5% with the loss of BRCA2 expression.ConclusionIHC was effective to detect loss of BRCA1 protein expression in EOC; however, data on BRCA2 expression were heterogeneous and difficult to interpret.
From what we know to what we do: enhancing absorptive capacity in translational health research
Authors: Currie Graeme , Kiefer Tina , Spyridonidis Dimitrios 
Published: November 2019

BackgroundGlobally, evidence about what works is slow to translate into frontline healthcare delivery. As a response, government policy has focused on translational health initiatives, such as the National Institute for Health Research funded Applied Research Collaborations in England. Concepts from organisation science prove useful to support such translational initiatives. We critique the application of two organisation science concepts linked to the broad domain of what is commonly termed ‘knowledge mobilisation’ in healthcare settings, specifically ‘knowledge brokers’ and ‘absorptive capacity’, to provide lessons for leaders of translational initiatives.ResultsThe presence of knowledge brokers to ‘move from what we know to what we do’ in healthcare delivery appears necessary but insufficient to have a system level effect. To embed knowledge brokers in the wider healthcare system so they draw on various sources of evidence to discharge their role with greatest effect, we encourage leaders of translational health research initiatives to take account of the concept of absorptive capacity (ACAP) from the organisation science literature. Leaders should focus on enhancing ACAP though development of ‘co-ordination capabilities’. Such co-ordination capability should aim not just to acquire different types of evidence, but to ensure that all types of evidence are used to develop, implement and scale up healthcare delivery that best benefits patients. Specific co-ordination capabilities that support translation of evidence are: clinician involvement in research and its implementation; patient and public involvement in research and its implementation; business intelligence structures and processes at organisational and system level.ConclusionAttention to the dimensions and antecedents of ACAP, alongside the implementation of the knowledge brokering solution, in translational health research initiatives, is likely to better ensure the latter’s success.
Capillary facilitation of skeletal muscle function in health and disease
Authors: Parise Gianni , Murrant Coral L. , Cocks Matthew , Snijders Tim , Baum Oliver , Plyley Michael J. 
Published: November 2019

Skeletal muscle is highly vascularized, with perfusion being tightly regulated to meet wide-ranging metabolic demands. For decades, the capillary supply has been explored mainly in terms of evaluating the capillary numbers and their function in the supply of oxygen and substrates and the removal of metabolic byproducts. This review will focus on recent discoveries concerning the role played by capillaries in facilitating other aspects of cell regulation and maintenance, in health and disease, as well as alterations during the aging process. Novelty Capillaries play a central role in the coordination of the vascular response that controls blood flow during contraction and the cellular responses to which they feed into. Nitric oxide is an important regulatory compound within the cardiovascular system, and a significant contributor to skeletal muscle capillary angiogenesis and vasodilatory response to agonists. The microvascular network between muscle fibres may play a critical role in the distribution of signalling factors necessary for optimal muscle satellite cell function.
Parton showers and matching uncertainties in top quark pair production with Herwig 7
Authors: Cormier Kyle , Plätzer Simon , Reuschle Christian , Richardson Peter , Webster Stephen 
Published: November 2019

Abstract
We evaluate the theoretical uncertainties in next-to-leading order plus parton shower predictions for top quark pair production and decay in hadronic collisions. Our work is carried out using the Herwig 7 event generator and presents an in-depth study of variations in matching schemes with two systematically different shower algorithms, the traditional angular-ordered and alternative dipole shower. We also present all of the required extensions of the Herwig dipole shower algorithm to properly take into account quark mass effects, as well as its ability to perform top quark decays. The predictions are compared at parton level as well as to Large Hadron Collider data, including in the boosted regime. We find that the regions where predictions with a non-top-quark-specific tune differ drastically from data are plagued by large uncertainties which are consistent between our two shower and matching algorithms.
On non-perturbative unitarity in gravitational scattering
Authors: Sachs Ivo , Tran Tung 
Published: November 2019

Abstract
We argue that the tree-level graviton-scalar scattering in the Regge limit is unitarized by non-perturbative effects within General Relativity alone, that is without resorting to any extension thereof. At Planckian energy the back reaction of the incoming graviton on the background geometry produces a non-perturbative plane wave which softens the UV-behavior in turn. Our amplitude interpolates between the perturbative graviton-scalar scattering at low energy and scattering on a classical plane wave in the Regge limit that is bounded for all values of s.
A way of decoupling gravitational sources in pure Lovelock gravity
Authors: Estrada Milko 
Published: November 2019

Abstract
We provide an algorithm that shows how to decouple gravitational sources in pure Lovelock gravity. This method allows to obtain several new and known analytic solutions of physical interest in scenarios with extra dimensions and with presence of higher curvature terms. Furthermore, using our method, it is shown that applying the minimal geometric deformation to the Anti de Sitter space time it is possible to obtain regular black hole solutions.
The Geological Survey of Denmark and Greenland (GEUS): from classical geological services to long-term environmental monitoring programmes, energy transformation and advice on political sensitive topics
Authors: Christiansen Flemming G. , Larsen Flemming 
Published: November 2019

Abstract
The Geological Survey of Denmark and Greenland (GEUS) has a long history and over the years there has been a strong focus on traditional survey work such as geological mapping, research and advice to authorities on questions related to geological and natural resources. Many of the services provided are continuing in the years to come but modern, complex society engenders new questions, where decisions must be based on the best available knowledge, and geological surveys are key players to provide this knowledge to governments. In the new millennium, GEUS has entered into a number of long-term environmental monitoring programmes and several political sensitive projects. Key examples described include groundwater monitoring, assessment of the risk of pesticide leaching to the groundwater, disposal of low-radioactive waste, Carbon Capture and Storage the Continental Shelf Project of the Kingdom of Denmark, monitoring of the Greenland Inland Ice, and other activities on the ice shield. It is expected that GEUS will be involved in even more such studies in the coming years and that the modernization of classical studies will continue. The revised strategy of GEUS to be launched in 2020 will be focused on the institutions input to meet the United Nations sustainable goals.
Geology for society in 2058: some down-to-earth perspectives
Authors: Smelror Morten 
Published: November 2019

Abstract

Social development and rapid growth in the world's population has followed a remarkable technological development the past hundred years. Revolutions in agriculture and industry, medical innovations and new production technologies, have led to an increased standard of living for a larger part of the Earth's population. Megatrends for future developments are lining up and predictions for the next 40 years are numerous. Most ideas about our future societies imply new and innovative geo-scientific achievements. Towards 2058, we will have virtually surveyed and mapped every corner of the Earth. We will have detailed 3D images of the urbanized areas, and 4D models to assist to make reliable forecasts in a world of increased pressure on the natural resources and changing ecosystems. By 2058 the Green Stone Age is established, and we will use all elements in the periodic system and more rare minerals to support new materials and technological solutions. The major energy supplies will be CO
2
free. The agriculture will be more efficient, distribution and consumption of food will be more rational, and we will harvest from more marine food chains than today. More than 70% of the people on Earth will live in megacities and urban areas. Our cities will become smarter and greener, cars and public transport will be self-driving and autonomous tools using artificial intelligence to automate functions previously performed by humans. Substantial resources will be used to repair damaged ecosystems, and most important, we will use materials and products that have fewer negative consequences for the environment. The 17 UN goals for sustainable development are guidelines into the future, and geological surveys should serve as key instruments in the transformation into smarter and more sustainable societies. We are already on our way providing critical minerals for low carbon energy solutions, marine knowledge for blue growth, plans for green and smarter cities, and advanced digitalization for public services, as shown by examples in this present paper.
The changing role of geological surveys in Malaysia
Authors: Abdullah Azizi Shahar Effendi , Ling Nan-Ley , Sia Say-Gee , Ismail Brendawati 
Published: November 2019

Abstract
Geological survey was first set up in Malaysia in 1903 mainly to facilitate tin mining activities that were started in the 1820s. Nevertheless, upon merging with the Department of Mines to form the Department of Mineral and Geoscience Malaysia (JMG), and also in order to meet the changing national needs, the new department has become increasingly relevant to a wide range of important national issues that help improve the well-being of society and contribute to the socio-economic development, an aspect that this paper describes. The changing role of the department is well reflected by the department being listed as a member of more than 57 technical committees in the country in the field of land-use planning, groundwater-resources management and mitigation of hazards. As we advance into the future, the department needs to ensure it is capable of rendering a more holistic service covering a wider spectrum of geological and geoscience activities to cater for the ever-increasing demands from society, industries, stakeholders and the government. For that reason, the Geological Survey Act, 1974 is being revised to beef up and provide the necessary jurisdiction in line with the duties, responsibilities and roles played by the JMG.