bluuebunny/crossref_metadata_2025_split huggingface dataset:
On Performance Improvement Of Reversible Data Hiding With Contrast Enhancement
Authors: Chen Haishan , Yuan Junying , Hong Wien , Ni Jiangqun , Chen Tung-Shou 
Published: June 2020

AbstractReversible data hiding (RDH) with contrast enhancement (RDH-CE) is a special type of RDH in improving the subjective visual perception by enhancing the image contrast during the process of data embedding. In RDH-CE, data hiding is achieved via pairwise histogram expansion, and the embedding rate can be increased by performing multiple cycles of histogram expansions. However, when embedding rate gets high, human visible image degradation is observed. Previous work designed an upper bound of the embedding level for RDH-CE, which effectively avoids image over-sharping but offers limited embedding capacity. In this paper, a better tunable bound is designed to enhance the embedding capacity of RDH-CE by exploiting the characteristics of histogram distribution. Furthermore, the objective distortion introduced by histogram pre-shifting is minimized when the embedding level is no more than the upper bound, and the human visible degradation is minimized when the embedding level exceeds the limitation of the proposed upper bound. Experimental results validate that the proposed method provides appropriate upper bound of the embedding level, increases the effective embedding capacity and offers better image contrast.
Endothelium-restricted endothelin-1 overexpression in type 1 diabetes worsens atherosclerosis and immune cell infiltration via NOX1
Authors: Ouerd Sofiane , Idris-Khodja Noureddine , Trindade Michelle , Ferreira Nathanne S , Berillo Olga , Coelho Suellen C , Neves Mario F , Jandeleit-Dahm Karin A , Paradis Pierre , Schiffrin Ernesto L 
Published: June 2020

Abstract

Aims
NADPH oxidase (NOX) 1 but not NOX4-dependent oxidative stress plays a role in diabetic vascular disease, including atherosclerosis. Endothelin (ET)-1 has been implicated in diabetes-induced vascular complications. We showed that crossing mice overexpressing human ET-1 selectively in endothelium (eET-1) with apolipoprotein E knockout (Apoe−/−) mice enhanced high-fat diet-induced atherosclerosis in part by increasing oxidative stress. We tested the hypothesis that ET-1 overexpression in the endothelium would worsen atherosclerosis in type 1 diabetes through a mechanism involving NOX1 but not NOX4.

Methods and results
Six-week-old male Apoe−/− and eET-1/Apoe−/− mice with or without Nox1 (Nox1−/y) or Nox4 knockout (Nox4−/−) were injected intraperitoneally with either vehicle or streptozotocin (55 mg/kg/day) for 5 days to induce type 1 diabetes and were studied 14 weeks later. ET-1 overexpression increased 2.5-fold and five-fold the atherosclerotic lesion area in the aortic sinus and arch of diabetic Apoe−/− mice, respectively. Deletion of Nox1 reduced aortic arch plaque size by 60%; in contrast, Nox4 knockout increased lesion size by 1.5-fold. ET-1 overexpression decreased aortic sinus and arch plaque alpha smooth muscle cell content by ∼35% and ∼50%, respectively, which was blunted by Nox1 but not Nox4 knockout. Reactive oxygen species production was increased two-fold in aortic arch perivascular fat of diabetic eET-1/Apoe−/− and eET-1/Apoe−/−/Nox4−/− mice but not eET-1/Apoe−/−/Nox1y/− mice. ET-1 overexpression enhanced monocyte/macrophage and CD3+ T-cell infiltration ∼2.7-fold in the aortic arch perivascular fat of diabetic Apoe−/− mice. Both Nox1 and Nox4 knockout blunted CD3+ T-cell infiltration whereas only Nox1 knockout prevented the monocyte/macrophage infiltration in diabetic eET-1/Apoe−/− mice.

Conclusion
Endothelium ET-1 overexpression enhances the progression of atherosclerosis in type 1 diabetes, perivascular oxidative stress, and inflammation through NOX1.
A Multiscale Characterization of Two Tropical Embiopteran Species: Nano- and Microscale Features of Silk, Silk-Spinning Behavior, and Environmental Correlates of their Distributions
Authors: Shenoy Samantha , Ing Keilyn , Barber Richard P , Rooks Edward C , Edgerly Janice S 
Published: June 2020

Abstract
Embioptera display the unique ability to spin silk with their front feet to create protective domiciles. Their body form is remarkably uniform throughout the order, perhaps because they all live within the tight confines of silken tubes. This study contributes to an understanding of the ecology of Embioptera, an order that is rarely studied in the field. We conducted a census to quantify the habitats of two species with overlapping distributions on the tropical island of Trinidad in a search for characteristics that might explain their distinct ecologies. One species, Antipaluria urichi (Saussure) (Embioptera: Clothodidae), lives in larger colonies with more expansive silk in habitats throughout the island, especially in the rainforest of the Northern Range Mountains. The other, Pararhagadochir trinitatis (Saussure) (Embioptera: Scelembiidae), was found only in lowland locations. We quantified silk-spinning behavior and productivity of the two species and found that A. urichi spins thicker silk sheets per individual and emphasizes spin-steps that function to create a domicile that is more expansive than that produced by P. trinitatis. Their silks also interact differently when exposed to water: the smaller-diameter silk fibers of P. trinitatis form more continuous films on the surface of the domicile after being wetted and dried than that seen in A. urichi silk. This tendency gives P. trinitatis silk a shiny appearance in the field compared to the more cloth-like silk of A. urichi. How these silks function in the field and if the differences are partially responsible for the distinct distributions of the two species remain to be determined.
J-Mart: aortic valve replacement with Florida sleeve aortic root reconstruction
Authors: Jeng Eric I , Martin Tomas D 
Published: June 2020

Abstract
We highlight a technique combining an aortic valve replacement with the Florida sleeve repair. The patient is a 68-year-old man who had a 48-mm aortic root aneurysm and a 57-mm ascending aorta, presenting with symptomatic tri-leaflet severe aortic valve stenosis. He underwent a hemiarch, aortic valve replacement and Florida sleeve aortic root reconstruction. The patient recovered uneventfully and is now, at over 1 year postoperation, without evidence of recurrent aortic pathology.
Catheter-based treatment of the dissected ascending aorta: a systematic review
Authors: Wang Changtian , von Segesser Ludwig Karl , Maisano Francesco , Ferrari Enrico 
Published: June 2020

Summary

OBJECTIVES

Type A aortic dissection requires immediate surgical repair. Despite improvements in surgery and anaesthesia, there is still a considerable risk when high-risk patients are concerned. Less invasive endovascular treatments are under evaluation. We investigated the current status of catheter-based treatment for type A aortic dissection with the entry tear located in the ascending aorta.

METHODS
A PubMed search was supplemented by searching through bibliographies and key articles. Demographics, risk score, stent graft detail, access route, mortality, cause of death, complications, reinterventions and follow-up data were extracted and analysed.

RESULTS
Thirty-one articles (7 retrospective reports; 24 case reports/series) were included in the study. In total, 104 patients (mean age 71 ± 14 years) received endovascular treatment for acute (63) or chronic (41) type A dissection. A history of a major cardiac or aortic operation was present in 29 patients. The mean EuroSCORE II was 30 ± 20 in 4 reports. A total of 114 stent grafts were implanted: ‘off-the-shelf’, 65/114; custom made, 12/114; and modified, 7/114. Hospital complications included intraprocedural conversion to open surgery (2/104), stroke (2/104), coronary stenting (2/104), early endoleak (9/104) and repeat aortic endovascular treatment for endoleak (5/104). Hospital mortality was 10% (intraoperative death 2/104). Mean duration of follow-up time was 21 ± 21 months (range 1–81 months); follow-up data were available for 86 patients: 10 patients died of non-aortic-related causes; reintervention for aortic disease (endovascular repair or open surgery) was performed in 8 patients.

CONCLUSIONS
Catheter-based ascending aorta repair for type A aortic dissection with the entry tear in the ascending aorta can be considered in carefully selected high-risk patients. Further analysis and specifically designed devices are required.
Recommendations for participation in competitive sport in adolescent and adult athletes with Congenital Heart Disease (CHD): position statement of the Sports Cardiology & Exercise Section of the European Association of Preventive Cardiology (EAPC), the European Society of Cardiology (ESC) Working Group on Adult Congenital Heart Disease and the Sports Cardiology, Physical Activity and Prevention Working Group of the Association for European Paediatric and Congenital Cardiology (AEPC)
Authors: Budts Werner , Pieles Guido E , Roos-Hesselink Jolien W , Sanz de la Garza Maria , D’Ascenzi Flavio , Giannakoulas George , Müller Jan , Oberhoffer Renate , Ehringer-Schetitska Doris , Herceg-Cavrak Vesna , Gabriel Harald , Corrado Domenico , van Buuren Frank , Niebauer Josef , Börjesson Mats , Caselli Stefano , Fritsch Peter , Pelliccia Antonio , Heidbuchel Hein , Sharma Sanjay , Stuart A Graham , Papadakis Michael 
Published: June 2020

AbstractImproved clinical care has led to an increase in the number of adults with congenital heart disease (CHD) engaging in leisure time and competitive sports activities. Although the benefits of exercise in patients with CHD are well established, there is a low but appreciable risk of exercise-related complications. Published exercise recommendations for individuals with CHD are predominantly centred on anatomic lesions, hampering an individualized approach to exercise advice in this heterogeneous population. This document presents an update of the recommendations for competitive sports participation in athletes with cardiovascular disease published by the Sports Cardiology & Exercise section of the European Association of Preventive Cardiology (EAPC) in 2005. It introduces an approach which is based on the assessment of haemodynamic, electrophysiological and functional parameters, rather than anatomic lesions. The recommendations provide a comprehensive assessment algorithm which allows for patient-specific assessment and risk stratification of athletes with CHD who wish to participate in competitive sports.
Assessment of causality of natriuretic peptides and atrial fibrillation and heart failure: a Mendelian randomization study in the FINRISK cohort
Authors: Geelhoed Bastiaan , Börschel Christin S , Niiranen Teemu , Palosaari Tarja , Havulinna Aki S , Fouodo Césaire J K , Scheinhardt Markus O , Blankenberg Stefan , Jousilahti Pekka , Kuulasmaa Kari , Zeller Tanja , Salomaa Veikko , Schnabel Renate B 
Published: June 2020

Abstract

Aims
Natriuretic peptides are extensively studied biomarkers for atrial fibrillation (AF) and heart failure (HF). Their role in the pathogenesis of both diseases is not entirely understood and previous studies several single-nucleotide polymorphisms (SNPs) at the NPPA-NPPB locus associated with natriuretic peptides have been identified. We investigated the causal relationship between natriuretic peptides and AF as well as HF using a Mendelian randomization approach.

Methods and results
N-terminal pro B-type natriuretic peptide (NT-proBNP) (N = 6669), B-type natriuretic peptide (BNP) (N = 6674), and mid-regional pro atrial natriuretic peptide (MR-proANP) (N = 6813) were measured in the FINRISK 1997 cohort. N = 30 common SNPs related to NT-proBNP, BNP, and MR-proANP were selected from studies. We performed six Mendelian randomizations for all three natriuretic peptide biomarkers and for both outcomes, AF and HF, separately. Polygenic risk scores (PRSs) based on multiple SNPs were used as genetic instrumental variable in Mendelian randomizations. Polygenic risk scores were significantly associated with the three natriuretic peptides. Polygenic risk scores were not significantly associated with incident AF nor HF. Most cardiovascular risk factors showed significant confounding percentages, but no association with PRS. A causal relation except for small causal betas is unlikely.

Conclusion
In our Mendelian randomization approach, we confirmed an association between common genetic variation at the NPPA-NPPB locus and natriuretic peptides. A strong causal relationship between natriuretic peptides and incidence of AF as well as HF at the community-level was ruled out. Therapeutic approaches targeting natriuretic peptides will therefore very likely work through indirect mechanisms.
Replication of 15 loci involved in human plasma protein N-glycosylation in 4802 samples from four cohorts
Authors: Sharapov Sodbo Zh , Shadrina Alexandra S , Tsepilov Yakov A , Elgaeva Elizaveta E , Tiys Evgeny S , Feoktistova Sofya G , Zaytseva Olga O , Vuckovic Frano , Cuadrat Rafael , Jäger Susanne , Wittenbecher Clemens , Karssen Lennart C , Timofeeva Maria , Tillin Therese , Trbojević-Akmačić Irena , Štambuk Tamara , Rudman Najda , Krištić Jasminka , Šimunović Jelena , Momčilović Ana , Vilaj Marija , Jurić Julija , Slana Anita , Gudelj Ivan , Klarić Thomas , Puljak Livia , Skelin Andrea , Kadić Antonia Jeličić , Van Zundert Jan , Chaturvedi Nishi , Campbell Harry , Dunlop Malcolm , Farrington Susan M , Doherty Margaret , Dagostino Concetta , Gieger Christian , Allegri Massimo , Williams Frances , Schulze Matthias B , Lauc Gordan , Aulchenko Yurii S 
Published: June 2020

Abstract
Human protein glycosylation is a complex process, and its in vivo regulation is poorly understood. Changes in glycosylation patterns are associated with many human diseases and conditions. Understanding the biological determinants of protein glycome provides a basis for future diagnostic and therapeutic applications. Genome-wide association studies (GWAS) allow to study biology via a hypothesis-free search of loci and genetic variants associated with a trait of interest. Sixteen loci were identified by three previous GWAS of human plasma proteome N-glycosylation. However, the possibility that some of these loci are false positives needs to be eliminated by replication studies, which have been limited so far. Here, we use the largest set of samples so far (4802 individuals) to replicate the previously identified loci. For all but one locus, the expected replication power exceeded 95%. Of the 16 loci reported previously, 15 were replicated in our study. For the remaining locus (near the KREMEN1 gene), the replication power was low, and hence, replication results were inconclusive. The very high replication rate highlights the general robustness of the GWAS findings as well as the high standards adopted by the community that studies genetic regulation of protein glycosylation. The 15 replicated loci present a good target for further functional studies. Among these, eight loci contain genes encoding glycosyltransferases: MGAT5, B3GAT1, FUT8, FUT6, ST6GAL1, B4GALT1, ST3GAL4 and MGAT3. The remaining seven loci offer starting points for further functional follow-up investigation into molecules and mechanisms that regulate human protein N-glycosylation in vivo.
Evaluation of Crohn’s Disease Activity: Development of an Ultrasound Score in a Multicenter Study
Authors: Ripollés Tomás , Poza Joaquín , Suarez Ferrer Cristina , Martínez-Pérez María J , Martín-Algíbez Ana , de las Heras Paez Berta 
Published: June 2020

Abstract

Objective
Our goal in this multicentric prospective study was 2-fold: first, to test the diagnostic accuracy of ultrasound, color Doppler imaging (CDI), and contrast-enhanced ultrasound (CEUS) in identifying disease activity in patients with Crohn’s disease (CD) compared with endoscopy as the reference standard; and, second, to construct a sonographic score that allows disease activity to be detected.

Materials and methods
Seventy-two patients with CD from 3 hospitals underwent within a 30-day period both colonoscopy and ultrasound (US), including mural thickness, CDI, and CEUS, prospectively as part of clinical care. A multivariate analysis was carried out to assess the influence of each of the ultrasound variables in predicting endoscopic activity. We then developed a predictive ultrasound score for disease activity, and a receiver operating characteristic (ROC) curve was constructed to determine the area under the ROC curve (AUC) and the best cut-off score value to discriminate between active and inactive disease.

Results
Sonographic findings that were independent predictors of the presence of active disease at endoscopy were wall thickness, color grade, and contrast parameters. A score based on those variables showed high accuracy in predicting active disease, with an area under the ROC curve of 0.972. A simpler index, without contrast parameters, also showed high accuracy in detecting disease activity (AUC, 0.923).

Conclusion
A score based on wall thickness, color Doppler grade, and contrast parameters showed high accuracy in predicting active disease. A score without including the use of contrast agent had practically similar results and is easier to use in monitoring response to treatment.
Association of Dietary Fatty Acid Intake With the Development of Ulcerative Colitis: A Multicenter Case-Control Study in Japan
Authors: Kobayashi Yumie , Ohfuji Satoko , Kondo Kyoko , Fukushima Wakaba , Sasaki Satoshi , Kamata Noriko , Yamagami Hirokazu , Fujiwara Yasuhiro , Suzuki Yasuo , Hirota Yoshio ,   Japanese Case-Control Study Group for Ulcerative Colitis, Iizuka Masahiro , Kohgo Yutaka , Inaba Yuhei , Hisabe Takashi , Matsui Toshiyuki , Futami Kitaro , Hanai Hiroyuki , Ishiguro Yoh , Tanaka Shinji , Ueno Yoshitaka , Watanabe Kenji , Ikeuchi Hiroki , Fujita Hiroshi , Tsubouchi Hirohito , Okazaki Kazuichi , Yoshioka Kazuhiko , Inoue Nagamu , Hibi Toshifumi , Kobayashi Kiyonori , Yokoyama Kaoru , Yamasaki Hiroshi , Mitsuyama Keiichi , Naito Yuji , Chiba Tsutomu , Nakase Hiroshi , Kusunoki Masato , Inatsu Haruhiko , Yamamoto Shojiro , Fujii Hisao , Hokari Ryota , Miura Soichiro , Sugimura Kazuhito , Iijima Hideki , Motoya Satoshi , Andoh Akira , Fujiyama Yoshihide , Ishihara Shunji , Kudo Shin-Ei , Ogata Noriyuki , Yoshimura Naoki , Watanabe Toshiaki , Ohtsuka Kazuo , Watanabe Mamoru , Kameoka Shingo , Itabashi Michio , Funayama Yuji , Kinjo Fukunori , Kitano Atsuo , Nakajima Atsushi , Takahashi Hirokazu , Higurashi Takuma , Sugita Akira 
Published: June 2020

Abstract

Background
Dietary fatty acids can affect chronic intestinal inflammation and have been reported to be associated with the development of ulcerative colitis (UC), mainly in Europe and the United States. The association of dietary intake of fatty acids and the risk for UC was investigated in Japan, where dietary habits lead to lower meat and higher fish consumption than in Western countries.

Methods
A multicenter case-control study of 83 newly diagnosed patients with UC and 128 age- and sex-matched control patients in the hospital was conducted from 2008 to 2014. Dietary fatty acid intake in the preceding 1 month and 1 year were examined using a self-administered diet history questionnaire that was developed for Japanese people.

Results
About 92% of patients had experienced the first symptoms of UC within the preceding 11 months. Regarding dietary habits in the preceding year, the risk for UC was significantly decreased in patients who consumed n-6/n-3 polyunsaturated fatty acids at a ratio of ≥5.2 (odds ratio [OR] = 0.26; 95% confidence interval [CI], 0.10-0.68). Conversely, an increased risk for UC was observed in the highest tertiles of consumption of docosahexaenoic acid (OR = 7.22; 95% CI, 2.09-24.95), eicosapentaenoic acid (OR = 6.91; 95% CI, 1.88-25.44), and docosapentaenoic acid (OR = 4.83; 95% CI, 1.56-14.95).

Conclusions
The ratio of n-6/n-3 polyunsaturated fatty acid intake was associated with a decreased risk for UC development. However, high intakes of docosahexaenoic acid, eicosapentaenoic acid, and docosapentaenoic acid may increase the risk for UC development.
Assessing the Morphological Impacts of Ammonoid Shell Shape through Systematic Shape Variation
Authors: Hebdon Nicholas , Ritterbush Kathleen , Choi YunJi 
Published: June 2020

Synopsis
A substantial body of research has been accumulated around ammonoids over several decades. A core aspect of this research has been attempting to infer their life mode from analysis of the morphology of their shells and the drag they incur as that shell is pushed through the water. Tools such as Westermann Morphospace have been developed to investigate and scaffold hypotheses about the results of these investigations. We use computational fluid dynamics to simulate fluid flow around a suite of 24 theoretical ammonoid morphologies to interrogate systematic variations within this space. Our findings uphold some of the long-standing expectations of drag behavior; conch inflation has the greatest influence over ammonoid drag. However, we also find that other long-standing assumptions, such as oxyconic ammonoids being the best swimmers, are subject to substantial variation and nuance resulting from their morphology that is not accounted for through simple drag assessment.
From catching up to industrial leadership: towards an integrated market-technology perspective. An application of semantic patent-to-patent similarity in the wind and EV sector
Authors: Hain Daniel S , Jurowetzki Roman , Konda Primoz , Oehler Lars 
Published: June 2020

AbstractStudies on catching up and industrial leadership have often used market-related variables to evaluate the catch-up trajectories of latecomer countries and firms. In this study, we aim to enhance our understanding of these concepts by presenting an integrated market-technology framework. Using natural language processing techniques allows us to go beyond patent numbers and analyze patent novelty and impact as well as technological changes over time. In empirical case studies on wind energy and electric vehicles in China, Japan, and South Korea, we compare and identify country and sector-specific catch-up trajectories and potential catch-up traps.
Genetic population structure and tools for the management of European sprat (Sprattus sprattus)
Authors: McKeown Niall J , Carpi Piera , Silva Joana F , Healey Amy J E , Shaw Paul W , van der Kooij Jeroen 
Published: June 2020

AbstractThis study used RAD-seq-derived SNPs to explore population connectivity, local adaptation, and individual assignment in European sprat (Sprattus sprattus) and inform the alignment of management units with biological processes. FST, clustering, and outlier analyses support a genetically cohesive population spanning the Celtic Sea-English Channel-North Sea-Kattegat (NE Atlantic) region. The lack of structure among the NE Atlantic samples indicates connectivity across current management boundaries. However, the assumption of demographic panmixia is cautioned against unless verified by a multidisciplinary approach. The data confirm high genetic divergence of a Baltic population (average FST vs. NE Atlantic samples = 0.051) with signatures compatible with local adaptation in the form of outlier loci, some of which are shown to occur within exonic regions. The outliers permit diagnostic assignment of individuals between the NE Atlantic and Baltic populations and thus represent a “reduced panel” of markers for monitoring a potential mixed stock fishery within the western Baltic. Overall, this study provides information that may help refine spatial management boundaries of sprat and resources for genetic-assisted management.