bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study
Authors: Liu Zhao-Yan , Yishake Dinuerguli , Fang Ai-Ping , Zhang Dao-Ming , Liao Gong-Cheng , Tan Xu-Ying , Zhang Yao-Jun , Zhu Huilian 
Published: January 2020

Abstract
Background: Higher choline/betaine levels have been linked to lower risk of liver cancer, whereas existing data in relation to hepatocellular carcinoma (HCC) prognosis are scarce. Our objective was to examine the associations of the serum choline and betaine with HCC survival. Methods: 866 newly diagnosed HCC patients were enrolled in the Guangdong Liver Cancer Cohort. Serum choline and betaine were assessed using high-performance liquid chromatography with online electro-spray ionization tandem mass spectrometry. Liver cancer-specific survival (LCSS) and overall survival (OS) were calculated. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs). Results: Both LCSS (T3 vs. T1: HR=0.69, 95% CI: 0.51-0.94; P-trend <0.05) and OS (T3 vs. T1: HR=0.73, 95% CI: 0.54-0.99; P-trend <0.05) were better with sex-specific tertiles of serum choline levels. The associations were not significantly modified across strata of selected prognostic factors, except in the different C-reactive protein (CRP) levels, the favorable associations between serum choline and LCSS and OS were only existed among patients with CRP ≥3.0 mg/L. No significant associations were found between serum betaine levels and either LCSS or OS. Conclusions: This study revealed that higher serum choline levels were associated with better HCC survival, especially in HCC patients with systemic inflammation status. No significant associations were found between serum betaine and HCC survival. Our finding might open new prospect in understanding the benefits of choline on HCC survival. Registration: The Guangdong Liver Cancer Cohort was registered at clinicaltrials.gov as NCT 03297255.
Prevalence and associated factors of metabolic syndrome among Chinese adults and elders with multi-level generalized estimation equation models
Authors: Xu Tao , Zhu Guangjin , Han Shaomei 
Published: January 2020

Abstract
Aim: The aim of this study is to examine prevalence of MetS and associated factors among Chinese adults and elders covering a broad age range from 18 to 80 years old with multi-level generalized estimation equation models. Methods: 28,062 subjects completed all blood biochemical testing. Subjects meeting at least 3 of the 5 criteria qualify as having MetS. Multi-level generalized estimation equation model was used to examine the relationship between MetS and covariates in order to control the cluster effect of living area.Results: 65.70% of all subjects had at least one clinical feature of MetS. 2926 subjects were diagnosed as MetS and the prevalence rate was 14.03%. The prevalence rate of MetS for males (12.31%) was lower than females (15.57%). After controlling the cluster effect of living areas, many demographic and life-style characteristics were associated with MetS. Overweight (OR=1.670, 95%CI: 1.600-1.743), obese subjects (OR=2.287, 95%CI: 2.136-2.449), current drinkers (OR=1.053, 95%CI: 1.020-1.086), physical laborers (OR=1.070, 95%CI: 1.040-1.101), subjects enjoying high-salted diet (OR=1.040, 95%CI: 1.009-1.071), subjects with hyperuricemia (OR=1.264, 95%CI: 1.215-1.316), subjects with less sleep duration (OR=1.032, 95%CI: 1.009-1.055), subjects with family history of cardiovascular diseases (OR=1.065, 95%CI: 1.019-1.113) or cerebrovascular diseases (OR=1.055, 95%CI: 1.007-1.104) could increase prevalence risk of MetS. risk of MetS would increase 6.9% (OR=1.069, 95%CI: 1.053-1.085) with each 5-percent increase of PBF.Conclusion: MetS has become a serious public health challenge in China. Changes of lifestyles including high fat, alcohol drinking, high-salted diet and less sleep duration were very important to control MetS.
Synthesis of Piperidine Conjugated Dihydroquinazolin-4(1H)-ones and their Antiproliferative Activity, Molecular Docking Studies and DFT Calculations
Authors: Narasimhamurthy Kereyagalahally Honneshappa , Chandra  , Swaroop Toreshettahally Ramesh , Jagadish Swamy , Rangappa Kanchugarakoppal Subbegowda 
Published: January 2020

Background:
Xanthatin, fluoropyrimidine and thienopyrimidine, pyrazolopyrimidine,
pyrimidine carboxamides, and SKLB1002 are reported as VEGFR2 tyrosine kinase inhibitors.
Recently, many studies related to different heterocycles conjugated with dihydroquinazolinones are
known to have very good biological activities. In this study, we are intended to explore the cytotoxic
studies of piperidine conjugated dihydroquinazolinones against colorectal/colon cancer cell lines and
along with molecular docking studies and DFT calculations.

Methods:
The colorectal/colon cell lines HCT116 and A549 cell lines were treated with these
compounds and cytotoxic activities were evaluated by MTT dye uptake method. We performed
molecular modelling for compound 3d using the Auto Dock software. The binding of compound 3d
with target proteins was studied with the collection of experimentally determined PDB database.
Optimized geometry by DFT calculations was performed with B3LYP/6-31G (d) basis set.

Results:
Piperidine-conjugated dihydroquinazolinone analogues displayed anticancer activity.
Particularly, the compound 3d with electron-withdrawing substituents on a phenyl ring showed
significant cytotoxicity against HCT116 and A549 cell lines. Molecular docking studies proved that
the compound 3d has good fitting by forming hydrogen bonds with amino acid residues at the active
sites of VEGFR2. The HOMO, LUMO, their energies and UV visible spectrum were predicted using
DFT calculations.

Conclusion:
Four piperidine-conjugated dihydroquinazolinones were synthesized and evaluated
against colorectal and colon cancer cell lines. Compound 3d significantly inhibited the growth of
HCT116 and A549. Molecular docking studies displayed good fitting of compound 3d by forming
different H-bonds with the amino acid at the active sites of the VEGFR2 target. Using a theoretical
approach, we optimized HOMO and LUMO plots for the compound 3d.
Experimental Investigation of the Physical and Mechanical Properties of Cassava Starch Modified Concrete
Authors: Oluwabusayo ONI Daniel , Mwero John , Kabubo Charles 
Published: January 2020

Background:
Concrete is a widely used material in construction, which has given rise to innovations in terms of modifying some of its properties to meet desired requirements. The use of chemical admixtures is important in this regard, which has necessitated the search for new materials which can serve as a substitute.

Objective:
This research work investigates the use of Cassava Starch (CS) as an admixture for improving the physical and mechanical properties of concrete.

Methodology:
The physical and mechanical properties of concrete were studied by adding CS by weight of cement at 0.4, 0.8, 1.2, 1.6 and 2.0%, respectively. Concrete cubes and cylinders were cast and cured for a test period of 7, 14, 28, 56 and 90 days, respectively. Unreinforced beams of size 150 x 150 x 530 were cast and cured for 28 days. A total of 6 mix proportion was used, five out of which were used to examine the effect of CS on the properties of concrete.

Results:
The workability of concrete reduced as the percentage of CS increased due to its viscosity modifying properties. CS increased the initial and final setting time of concrete for every increase in percentage addition. An improvement in the compressive strength, split tensile strength, flexural strength and elastic modulus of concrete were noticed for cassava starch-modified concrete over the control for some of the mixes at all days of curing. The density of concrete was found to decrease at 1.6 and 2.0% addition of CS in concrete.

Conclusion:
From the results of this investigation, CS improved the compressive, split tensile, flexural and elastic modulus of concrete at an optimum of 0.8 percentage addition of CS. The setting time of concrete was also increased, which makes CS suitable to be used as a retarding admixture in hot weather concreting. Based on the findings of the work, CS can be considered as an admixture to be used as a substitute for retarders and viscosity modifying admixtures for improved concrete properties.
Impactos socioambientais na Amazônia Oriental: um olhar a partir da atividade siderúrgica na comunidade Piquiá de Baixo - Açailândia (MA)
Authors: Silva Lucas Ribeiro da 
Published: January 2020

Este trabalho aborda a questão do desenvolvimento econômico, buscando enfatizar a implantação de grandes projetos na Amazônia Oriental, em especial, os empreendimentos siderúrgicos, além disso, retrata os impactos decorrentes de tais iniciativas. Dessa forma, o objetivo central deste estudo é analisar o processo de implantação de siderúrgicas na cidade de Açailândia - MA e as consequências não só ambientais, como também sociais, culturais e territoriais que acabam por afetar diretamente as populações adjacentes, em especial a comunidade Piquiá de Baixo. Por se tratar de uma pesquisa de cunho qualitativo, adotou-se como estratégias metodológicas, a pesquisa bibliográfica, além da observação simples e a análise de dados levantados junto à comunidade.
Group Guidance Based on Gestalt Theory to Develop Creativity in Learning
Authors: Putri Rizki Diana 
Published: January 2020

Creativity in learning is a character that is the power of individuals to be able to complete their competence in learning. In learning, creativity makes students sensitive or aware of problems, shortages, understanding in knowledge, by gathering existing information, limiting information, or connecting (looking for) nothing, finding answers, making hypotheses, changing, and testing them. It is accepted and finally communicates the results. The purpose of this study is to get a complete picture of the learning process and group guidance using Gestalt in developing learning creativity. The research method uses literature studies. In operational terms, creativity in learning requires students to be able to reflect the abilities that are responsible for the burden, burden, and the learning process. The understanding resulting from the reflection process becomes a reference in the formulation of the problem. The results of the literature study show that group guidance with Gestalt theory can help students develop their creativity in learning. Give advice about assistance when interacting and interpersonal problems, as well as creativity assistance, implemented to support/bring up productive solutions in efforts to improve Gestalt. Gestalt-based group tutoring to develop learning creativity gathers students to find opinions about the challenges of learning, to finally find the discovery of actions that are appropriate for yourself. Group techniques that can be used are lap exercises, fantasy exercises, and homework
Biologia no PNLD 2018: o que temos de Caatinga?
Authors: Nepomuceno Izaíra Vasconcelos , Terra Bianca de Freitas 
Published: January 2020

Muitos livros didáticos ainda são carentes de informações sobre o domínio da Caatinga e reproduzem mitos quanto à sua diversidade, processos ecológicos e importância socioeconômica. Diante disso, o objetivo deste estudo foi avaliar como o Domínio Fitogeográfico da Caatinga é abordado nos livros didáticos de Biologia sugeridos pelo PNLD 2018 para o Ensino Médio. Foram analisados os 10 livros propostos pelo PNLD para a disciplina de Biologia no Ensino Médio. Para a análise, foram considerados os seguintes critérios: informações acerca do domínio, uso de imagens de fauna e flora. Foi observada uma assimetria em relação ao espaço direcionado a cada “bioma” no livro didático. Porém, a maioria dos livros caracterizou corretamente a área de ocorrência e fisionomia da vegetação, além de utilizar imagens. Ao contrário do que se pensava, foram destinadas ao estudo da Caatinga um número considerável de páginas, garantindo assim, com as informações corretas e uso de textos visuais, a ampliação do conhecimento sobre as principais características desse Domínio. Palavras-chave: Ensino Médio. Caatinga. Livro didático.
Identidade docente: representações de professores/as em narrativas ribeirinhas do Rio Quianduba em Abaetetuba-Pa
Authors: Correa Maria Francisca Ribeiro , Abreu Waldir Ferreira de , Oliveira Damião Bezerra 
Published: January 2020

O artigo apresenta os resultados da pesquisa sobre Identidade Docente: Representações de Professores/as em narrativas ribeirinhas do Rio Quianduba em Abaetetuba. O objetivo foi analisar as representações de Professores/as construídas e veiculadas na oralidade dessa comunidade, considerando a relação com a prática docente no cotidiano escolar. Adotou-se como lócus de investigação a Comunidade do Rio Quianduba no Município de Abaetetuba, Pará. As bases conceituais da pesquisa seguiram as orientações e abordagens de teóricos como Ciampa, Arroyo e Nóvoa, com os quais sustentamos as discussões e análises sobre identidade e representação; Williams é usado como referência para trabalhar a concepção de cultura enquanto meio de produção da existência. A metodologia de pesquisa pautou-se nas concepções e orientações do Materialismo Histórico Dialético com realização de Pesquisa de Campo e a utilização das narrativas orais como fonte de investigação. Palavras-chave: Identidade. Representação. Cultura.
Desenho universal para aprendizagem: reflexões sobre o desenvolvimento de aulas de Matemática
Authors: Neves Frank Presley de Lima , Peixoto Jurema Lindote Botelho 
Published: January 2020

O contexto educacional inclusivo tensiona um currículo prescritivo, de formato único, pois não tem contemplado diferenças na aprendizagem dos estudantes. Nesse sentido, é importante encontrar alternativas para a experimentação de propostas que se distanciem dessa concepção. Esse estudo teve a finalidade de analisar o desenvolvimento de aulas de matemática na abordagem curricular do Desenho Universal para a Aprendizagem (DUA) e suas implicações para a prática reflexiva do professor. Para tanto, foi desenvolvida uma pesquisa-ação no contexto de uma formação continuada, durante os horários de atividades complementares. A formação enfocou a Educação Inclusiva, a abordagem curricular do DUA, o planejamento e desenvolvimento de aulas de Matemática. Participaram da pesquisa três professores que ensinam Matemática em uma escola pública do sul da Bahia, que possuíam estudantes com deficiência em sua turma. Os dados foram produzidos no processo formativo, a partir da observação participante, registros no diário de campo e relatos escritos dos professores. Os resultados sugerem que o planejamento e o desenvolvimento de aulas baseado no DUA contribuíram para que esses profissionais repensassem sua ação docente de maneira reflexiva e buscassem estratégias de promoção para um ensino de Matemática para todos. Palavras-chave: Desenho Universal para a Aprendizagem. Currículo. Ensino de Matemática.
As experiências com o ensino e a aprendizagem de matemática dos medalhistas cegos da Olimpíada Brasileira de Matemática das escolas públicas (OBMEP)
Authors: Martins Daner Silva , Galiazzi Maria do Carmo , Lima Cleiva Aguiar de 
Published: January 2020

Este trabalho apresenta uma análise acerca das experiências escolares dos medalhistas cegos da Olimpíada Brasileira de Matemática das Escolas Públicas. A presente investigação visa compreender os processos relativos ao ensino e à aprendizagem da disciplina durante a trajetória escolar destes estudantes, a fim de contribuir com outros alunos cegos e com a formação de professores. Para tanto, foram realizadas entrevistas narrativas com os medalhistas, no intuito de escutar suas histórias acerca dos processos de ensino e aprendizagem de Matemática vivenciados durante a Educação Básica. Para analisar os elementos emergentes das referidas falas, foi adotada a Análise Textual Discursiva. As barreiras impostas pela sociedade, o reconhecimento do outro e as especificidades da cegueira a partir do (re)conhecimento de si emergiram como elementos que compõem as categorias implicadas nestas experiências. A abordagem destes temas tem o potencial de contribuir com docentes em formação para o ensino de Matemática na perspectiva inclusiva. Palavras-chave: Ensino de Matemática para Cegos. Formação de Professores de Matemática. Educação Matemática Inclusiva. Olimpíada Brasileira de Matemática das Escolas Públicas.
Ensino de Matemática para surdos: mapeamento de pesquisas sobre resolução de problemas
Authors: Pinheiro Fabrício Andrade , Muniz Salvador Cardoso Silva , Peixoto Jurema Lindote Botelho , Madruga Zulma Elizabete de Freitas 
Published: January 2020

Este artigo tem como objetivo analisar pesquisas acadêmicas que tratam da inclusão de estudantes surdos e enfocam a resolução de problemas. Para tanto foi utilizado o mapeamento na pesquisa educacional como procedimento metodológico. Foram realizadas buscas em revistas de Qualis A1 a B2, portal de teses e dissertações da CAPES, Google Acadêmico e Scielo, utilizando-se para tanto as palavras-chave ‘inclusão de surdo’, ‘inclusão e resolução de problemas’ e ‘situações problemas’. Após filtragem dos resultados, foram encontrados seis artigos que fizeram parte do corpus de análise. Os resultados mostraram que a inclusão não está ocorrendo de forma efetiva, pois o professor ainda não está preparado para atender alunos surdos e, consequentemente, ensinar Matemática para esses estudantes. Destaca-se também o número reduzido de pesquisas que tratam sobre a inclusão de surdos tendo a resolução de problemas como foco.
Palavras-chave: Ensino de Matemática. Inclusão de surdos. Resolução de problemas.
المحسنات اللفظية في سورة الرحمن (دراسة تحليلية بلاغية)
Authors: Syahran Muhammad 
Published: January 2020

تهدف هذه الأطروحة إلى معرفةالمحسنات اللفظية وأغراضها في سورة الرحمن. وأما مناهجها المستخدمة، فهي تنقسم إلى منهجين، أحدهما: منهج جمع المواد باستخدام الوسيلة المكتبية، وثانيهما: منهج تنظيم وتحليل المواد باستخدام ثلاثة مناهج، وهي: المنهج الاستقرائي، والمنهج الاستنباطي، والمنهج المقارن اللغوي والتاريخي. وأما من نتائج البحث فقد دلت على أن المحسنات اللفظية في سورة الرحمن تتكون من أربع محسنات، وهي:1) السجع المرصع في موضع واحد،2) والجناس بنوعيه المماثل والناقص في ثلاثة مواضع،3) وحسن الابتداء أو براعة الاستهلال في موضع واحد،4) وحسن الاختتام أو مسك الختام في موضع واحد، فصار مجموع هذه المحسنات اللفظية أربعة في ستة مواضع. وكذلك دلت على أن أغراض المحسنات اللفظية في سورة الرحمن تكون في أربعة أغراض، وهي: 1) الإعجاز اللغوي، 2) والإعجاز الموسيقي أو النغمي، 3) والحِكَم 4) وعلم الساعة. وكل هذه الأغراض داخلة في مسميات رحمة الله وآلآئه. ولقد شيدت -إن صح التعبير- هذه الأطروحة اللَّبِنَةَ الأساسيةَ في مشروع علمي متعاون بين الدراسات القرآنية التفسيرية والدراسات البلاغية البديعية بخصوص المحسنات اللفظية، فالمأمول من الإخوة الباحثين والدارسين أن يواصلوا بناء هذا المشروع المجيد الذي قد تشيدت بنيته المتينة، وإلا فلا أقل من دراسات تعالج تخصيص الأبواب التي لم تزل عامة أو تبيينَ الأبواب التي لم تزل مجملة في المؤلفات الإسلامية حتى تسهل الاستفادة منها وِفقَ الرغبات العلمية الكثيرة وطِبقَ الحماسات المعرفية المتنوعة.الكلمات المفتاحية: المحسنات اللفظية، سورة الرحمن، دراسة تحليلية بلاغية AbstrakTujuan artikel ini adalah untuk mengetahui al-Muhassināt al-Lafẓiyyah dan tujuan-tujuannya dalam Surah al-Rahmān. Metode yang digunakan untuk mengatur dan menganalisis data ada tiga: pendekatan induktif, pendekatan deduktif, dan metode linguistik historis komparatif. Adapun hasil penelitian telah menunjukkan bahwa al-Muhassināt al-Lafẓiyyah dalam Surah al-Rahmān terdiri dari empat Muhassināt: 1) al-Saja' al-Muraṣṣa' di satu tempat, 2) al-Jinās dengan dua jenisnya al-Mumāṡil dan al-Nāqiṣdi 3 tempat dan 3) Barā'ah al-Istihlāl, dan 4) Husnu al-Khitām, sehingga total al-Muhassināt al-Lafẓiyyah dalam Surah al-Rahmān adalah empat pada enam tempat. Hasil penelitian Ini juga menunjukkan bahwa tujuan dari al-Muhassināt al-Lafẓiyyah dalam Surah al-Rahmān ada dalam empat tujuan: 1) mukjizat linguistik, 2) mukjizat musik atau irama, 3) hikmah-hikmah 4) dan ilmu tanda-tanda kiamat. Semuanya ini termasuk dalam kategori Rahmat dan Nikmat karunia Allah swt. Diharapkan bagi saudara-saudara, para peneliti, dan cendekiawan, untuk melanjutkan proyek yang mulia ini yang telah terbangun strukturnya yang kokoh. Minimal ada studi dan kajian yang mengkhusukan bab-bab yang masih bersifat umum atau merinci pembahasan yang masih global dalam literatur Islam sehingga mudah diambil manfaatnya sesuai dengan keinginan ilmiah yang beragam dan latar belakang pengetahuan yang berbeda.
Strategi Pemetaan Kompetensi pada Seleksi Calon Penghulu di Lingkungan Kantor Wilayah Kementerian Agama Kalimantan Timur dan Kalimantan Utara
Authors: Rosliana Lia , Kusumaningrum Mayahayati , Hidayah Kemal , Arieyasmieta Wildan Lutfi 
Published: January 2020

Changes in the candidate selection process is a strategy in to improve human resources under the spirit of bureaucratic reform within the Ministry of Religious Affairs of Indonesia. The selection of position selection must pay attention to the competency mapping, as stipulated in Decree of Minister of Religion of the Republic of Indonesia Number 208 the Year 2017 concerning guidelines for adjustment/inpassing, competency test, and determination of functional needs of penghulu. This This research was a descriptive method with a qualitative approach, namely through a diagnosis from the desk research and review of the results of the competency test and core reports on the selection of prospective leaders in the Ministry of Religious Affairs of Republic Indonesia, East Kalimantan and North Kalimantan regional office. The results of the study showed that competency mapping strategies carried out in the selection of functional need of penghulu produce a profile officer that can be source information of candidate capability. This is conducted for the needs of functional development of penghulu in the future Competency mapping strategies need to be carried out continuously so that all the functional positions of penghulu can be optimally enhanced.
Keywords: Selection, Strategy, Competence Mapping, Penghulu
Abstrak
Perubahan proses seleksi calon penghulu merupakan strategi dalam memperbaiki area perubahan sumber daya manusia sesuai dengan semangat reformasi birokrasi di lingkungan Kementerian Agama Republik Indonesia. Seleksi jabatan harus memperhatikan pemetaan kompetensi, sebagaimana yang diatur dalam Keputusan Menteri Agama Republik Indonesia Nomor 208 Tahun 2017 tentang Pedoman Penyesuaian/ Inpassing, Uji Kompetensi dan Penetapan Kebutuhan Jabatan Fungsional Penghulu. Penelitian ini bersifat deskriptif dengan pendekatan metode kualitatif, yaitu melalui analisis dari desk riset dan telaah hasil laporan uji kompetensi inti dan kompetensi manajerial pada seleksi calon penghulu di Kementerian Agama Republik Indonesia Kantor Wilayah Kalimantan Timur dan Kalimantan Utara. Hasil penelitian menunjukkan bahwa strategi pemetaan kompetensi yang dilakukan dalam seleksi jabatan fungsional penghulu memberikan hasil profil pegawai yang dapat dijadikan salah satu sumber informasi kemampuan peserta seleksi. Hal ini dilakukan untuk kepentingan pengembangan kepegawaian para fungsional penghulu dimasa yang akan datang. Strategi pemetaan kompetensi perlu terus dilakukan sehingga semua jabatan fungsional penghulu ini dapat ditingkatkan kompetensinya secara optimal.
Kata Kunci: Seleksi, Strategi, Pemetaan Kompetensi, Penghulu