bluuebunny/crossref_metadata_2025_split huggingface dataset:
A non-contact system for the assessment of hand motor tasks in people with Parkinson’s disease
Authors: Monteiro Oliveira Fábio Henrique , Fernandes da Cunha Daniel , Gomes Rabelo Amanda , David Luiz Luiza Maire , Fraga Vieira Marcus , Alves Pereira Adriano , de Oliveira Andrade Adriano 
Published: January 2021

AbstractClinical diagnosis of Parkinson’s disease (PD) motor symptoms remains a problem. Most of the current studies focus on objective evaluations to make the evaluation more reliable. Most of these systems are based on the use of inertial and electromyographic sensors that require contact with the body part being assessed. Contact sensors restrict natural movement, may be uncomfortable and may require preparation of the body, which may cause irritation. As an alternative to contact sensors for the study of hand motor tasks performed by subjects with and without PD, electrical potential sensing technology is used in this research. A custom hardware has been designed to enable data collection by hand movement. A micro-machine system validated the developed system, and a relationship model was established between hand displacement and non-contact capacitive (NCC) sensor response. An experiment was conducted, including 57 subjects, 30 with PD (experimental group) and 27 healthy control group, followed by an analysis of statistical features extracted from the instantaneous mean frequency (IMNF) of NCC sensor. These results were compared with those obtained from gyroscope signals that are considered in the field to be the gold standard. As a result, NCC responses were correlated linearly with hand displacement (R2 = 0.7692 and $${\text{R}}_{\text{adj}}^{2}$$

R

adj

2

= 0.7631). The statistical evaluation of IMNF features showed, that both, contact and non-contact sensors, were able to discriminate movement patterns of the control group from the experimental one. The results confirm statistical similarity between features extracted from NCC and gyroscope signals.
Tool wear analysis in milling of locomotives wheels
Authors: Pacheco P. A. P. , Esteves Júnior R. C. , Mendes T. J. P. , Meireles B. , Formigon I. 
Published: January 2021

AbstractThe present work aims to evaluate the tool wear during the milling process of locomotives wheels—class C. A digital microscope is used to identify both the wear and the damage. The wear or damage, when propagated, can compromise the wheel roughness, which has a significant economic importance to railroad maintenance. A system for image capture composed of an ISM-PM200S INSIZE Digital Microscope and the ISM-Pro software is used to measure the flank wear. Firstly, milling process is applied with different numbers of passes. The results showed that, after flank wear, the most common wear is the thermal crack. It is also possible to observe the appearance of chipping and fracture as a consequence of the combination of thermal and mechanical cracks in the same insert. The inserts are more damaged in the raceway, due to the hardening of this region during its use. Inserts in the frieze region also showed higher values of wear, justified by the conditions of the railway. The highest values observed are around 0.1 mm. It is possible to notice that some inserts showed other damages, such as breaks and chipping, even before reaching the end of life due to wear.
Degradation of high energetic material hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) by a microbial consortium using response surface methodological approach
Authors: Sharma Kirty , Sharma Praveen , Celin S. Mary , Rai Pramod Kumar , Sangwan Pritam 
Published: January 2021

AbstractSoil and water get polluted with hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) during its manufacturing, storage and use for civil and military purposes. RDX has toxic effects on living and non-living environment and is a recalcitrant compound. Therefore, the remediation of this compound is necessary. Microbial degradation of RDX can be a suitable and sustainable option to reduce its deleterious impact on the environment. Therefore, the optimization for degradation of energetic munition compound RDX employing the consortium of native bacterial species, isolated from an actual contaminated site, was performed. The experiment was planned with three independent variables (initial RDX concentration, inoculum size of microbes, and duration of the experiment) and three dependent variables (percentage removal of RDX, optical density, and nitrite release). Both independent and dependent variables were analyzed by the response surface methodology (RSM) using the Box–Behnken design. The statistical analysis using analysis of variance (ANOVA) depicted a high regression coefficient, R2 = 0.9881 with the statistically significant p-value fitted into a quadratic regression model for percentage removal of RDX. Results showed an initial RDX concentration of 40 mg/L, inoculation size 6 mL and a time duration of 12 days was optimal for the reduction of RDX up to 80.4%.
On the optimum operating temperature for steam floods
Authors: Lawal Kazeem A. , Olamigoke Olugbenga 
Published: January 2021

AbstractThe technical, environmental and economic performances of a steam flood are partly influenced by the operating temperature (pressure). However, the definition and procedure for determining the optimum operating temperature are still debatable. Employing a combination of analytic modelling and numerical simulations, this paper investigates the existence (or otherwise) of an optimum injection temperature Topt for saturated-steam floods. Considering the maximization of productivity and thermal efficiency as objective, an analytic procedure, which explores the effects of temperature on injectivity, total steam enthalpy, oil viscosity and relative permeabilities, shows that the operating temperature (pressure) of a steam flood should not exceed 515 K (3.5 MPa). A simple closed-form expression is proposed for Topt as a function of basic rock and fluid properties. For an example three-dimensional reservoir model comprising an 8-m oil shale unit sandwiched between two sandy units each 15 m thick, numerical simulations show sensitivity to temperature (and viscosity effect) in the range 350–450 K, but becomes increasingly insensitive in the band 500–650 K. It is established that ~500–550 K is the optimum band when the optimization objective is to maximize both discounted oil recovery and cumulative oil-steam ratio. These results agree with an optimum injection temperature of ~501 K estimated from the proposed analytical model in this case. Therefore, based on the results of the analytical model, thermal simulations and other considerations, it is concluded that the optimum steam-injection temperature is project and system specific. The insights gained should find relevance in the design and management of steam floods, as well as other steam-based recovery processes.
The potential use of lightweight cellular concrete in pavement application: a review
Authors: Ni Frank Mi-Way , Oyeyi Abimbola Grace , Tighe Susan 
Published: January 2021

AbstractProtecting the pavement subgrade to increase the service life of road pavements is an aspect currently being explored. Several alternative pavement subbase materials are being considered, including Lightweight Cellular Concrete (LCC). Due to its lower weight, LCC incorporating industrial by-product, making it sustainable, and ease of use amongst other benefits, is seen as a potential candidate. This paper reports reviewing the potential application of LCC within the pavement structure with a specific application as a subbase. It examines the various properties such as modulus of elasticity, compressive and tensile strength, Water absorption, and freeze-thaw resistance necessary for pavement application. It also assesses its use in the field in Canada considering the design methods utilized. Some limitations and gaps for LCC application in pavements are also established and recommendations on how to further its use and performance. This review concludes that LCC possesses potential as a pavement subbase alternative; however, other mechanical properties like LCC’s fatigue life is essential. A comparative field study is also recommended to monitor actual performance and various factors on performance.
Experimental study of base stabilization with fibrillated fiber
Authors: Chen Dar-Hao , Rew Younho , Tapase Anand Bajarang , Crockford William 
Published: January 2021

AbstractPotential benefits in applying polypropylene fiber to stabilize expansive soils and cement treated bases is already been reported in previous studies. So a critical need exists to incorporate the use of fiber into the Texas Department of Transportation’s (TxDOT’s) Guidelines for Modification and Stabilization of Soils and Base for Use in Pavement Structures. The present paper discusses the results collected from the first experimental test section on FM897 in the TxDOT Paris District. Three 500-ft (152.4m) test sections were constructed with 2 percent cement on FM897 in February 2020 in the north bound lane loaded truck direction which includes a new sandstone base, full depth reclamation (FDR), and control. However, only the new sandstone base and FDR sections were built with fiber. In this project, two types of fibers were used —(a) fibrillated fiber Fibermesh300, and (b) macro-synthetic fiber Enduro 600. The surface and base layers from the new sandstone base section were removed and used for the edge widening area of the FDR and control sections. Based on the laboratory tests, the optimum fiber contents were found to be 0.6 percent and 0.4 percent for a new sandstone base and FDR, respectively. The laboratory Unconfine Compression Strength (UCS) results showed significant improvements (<112.36 percent) when fibers were added to the sandstone base. To have better control, fiber and cement were manually distributed, following the US Army Corps of Engineers’ recommendations. Becaus e of unexpected construction equipment failure that caused compaction delays of approximately 5 hours, cement was in contact with moisture for approximately 5 hours before compaction. UCS results showed an approximate 55 percent reduction when there was a 5-hour delay from the time water was introduced (resulting in the start of the hydration process) until the time of compaction. It indicated that there are detrimental effects on UCS if there is delay on compaction. There were significant reductions on the normalized W1 deflections at 5 months after construction. In particular, the FDR and new sandstone base sections (with fiber) experienced over 52 percent reduction as compared to 1 week after construction FWD data. Furthermore, the averaged W1 deflections were lower than before construction for both FDR and new sandstone base sections (with fiber). This indicates that there were rapid increases in structural capacity and significant strength developed in the fiber sections between 1 week and 5 months. Further research is needed to explain the mechanism and phenomena.
Recent advances in characterizing the “bee” structures and asphaltene particles in asphalt binders
Authors: Wang Yuhong , Zhao Kecheng , Li Fangjin , Gao Qi , Lai King Wai Chiu 
Published: January 2021

AbstractThe microscopic surface features of asphalt binders are extensively reported in existing literature, but relatively fewer studies are performed on the morphology of asphaltene microstructures and cross-examination between the surface features and asphaltenes. This paper reports the findings of investigating six types of asphalt binders at the nanoscale, assisted with atomic force microscopy (AFM) and scanning transmission electron microscopy (STEM). The surface features of the asphalt binders were examined by using AFM before and after being repetitively peeled by a tape. Variations in infrared (IR) absorbance at the wavenumber around 1700 cm−1, which corresponds to ketones, were examined by using an infrared s-SNOM instrument (scattering-type scanning near-field optical microscope). Thin films of asphalt binders were examined by using STEM, and separate asphaltene particles were cross-examined by using both STEM and AFM. In addition, connections between the microstructures and binder’s physicochemical properties were evaluated. The use of both microscopy techniques provide comprehensive and complementary information on the microscopic nature of asphalt binders. It was found that the dynamic viscosities of asphalt binders are predominantly determined by the zero shear viscosity of the corresponding maltenes and asphaltene content. Limited samples also suggest that the unique bee structures are likely related to the growth of asphaltene content during asphalt binder aging process, but more asphalt binders from different crude sources are needed to verify this finding.
Durability assessment of open-graded friction course using a sustainable polymer
Authors: Al-Busaltan Shakir , Al-Yasari Rand , Al-Jawad Ola , Saghafi Behrooz 
Published: January 2021

AbstractOpen-graded friction course (OGFC) asphalt mixture, usually used to construct porous pavements, represents one of the materials supporting low-impact development (LID) philosophy due to its use of coarse aggregate gradation. Using such mixtures brings several benefits related to safety, environment and economy. Alas, coarse, open-graded skeleton of OGFC mixtures is prone to failure, particularly raveling and stripping. Continuous traffic loading and the environmental impacts give hand in hand to further increase the potential for failure, hence higher pavement maintenance and rehabilitation costs. Application of different types of modifiers has proved effective in mitigating failure potential. The most common modifiers are polymers, fibers and anti-stripping agents. Aiming at minimizing the costs and maximizing the lifespan while considering sustainability, the study was to investigate the effect of using a recycled stabilizing material as an asphalt modifier on the performance of OGFC asphalt mixtures. Recycled Low-Density Polyethylene (R-LDP) was adopted in this investigation. Changes in mixture air void, porosity, draindown, permeability, rut depth, moisture damage and abrasion loss were observed to evaluate the effect. Compared with unmodified asphalt samples, R-LDP modification increased mixture air void, porosity and permeability by 15%, 10% and at least 40%, respectively. Also, it noticeably contributed to reducing rut depth, moisture damage and abrasion loss (both unaged and aged) by 31%, 20% and at least 40%, respectively. More significantly, it almost eliminated the draindown problem. Incorporating R-LDP proved effective in upgrading OGFC mixture properties to an acceptable level required by most specifications.
Development of a 4.75 mm asphalt mixture design for Implementation in Louisiana DOTD Specifications
Authors: Salari Saman , Cooper Samuel , Mohammad Louay N. , Barghabany Peyman 
Published: January 2021

AbstractThe Louisiana Department of Transportation and Development (DOTD) and other state agencies are continuously looking for techniques to reduce roadway maintenance and construction costs. A common consideration is to introduce asphalt mixtures with a smaller nominal maximum aggregate size (NMAS) for utilization in roadways. In a previous study, DOTD concluded that mixtures with a 4.75 mm NMAS provided acceptable performance as a surface layer. Excessive stockpiles of unused smaller aggregates can result in an economically competitive source to be consi dered for asphalt mixtures. The DOTD developed mixtures with four aggregate types and two binder types. A comprehensive evaluation of performance was conducted through volumetric and mechanistic testing. Performance testing consisted of the Loaded Wheel Tracking (LWT) test to determine rutting resistance, Semi-Circular Bend (SCB) test to evaluate intermediate temperature cracking resistance, and dynamic modulus (E*) to ascertain the stiffness at intermediate temperatures. As expected, asphalt binder grade, aggregate type and mixture composition affected the performance of mixtures evaluated. Gravel mixtures were susceptible to cracking, while limestone mixtures were susceptible to rutting. An economic analysis was conducted to determine the viability of 4.75 mm mixtures. The cost per ton of 4.75 mm mixtures in Louisiana was higher than conventional 12.5 mm mixtures. However, when considering the lift thickness of potential overlays, the 4.75 mm aggregate mixtures became more viable. Further, a life-cycle analysis of a designed pavement using AASHTO Pavement-ME was performed to compare the lifetime durability of the 4.75 mm NMAS mixtures to a conventional 12.5 mm mixture.
An Asian nostalgia?
Authors: Mitter Rana 
Published: January 2021

AbstractSearching for common themes, this afterword questions the meaning and experience of nostalgia in Asia today. The collected essays show the important roles that conflict, trauma, and the need to create a new modernity shape, and are shaped by notions of nostalgia through much of Asia. Perhaps more so than in Europe, nostalgia in Asia seems very national. The case studies in this collection are excellent examples of how nostalgic longings are deployed to enhance national power, as well as a demonstration of the enduring influence of the nation-state over individual imagination across the region.
A tough trade-off? The asymmetrical impact of populist radical right inclusion on satisfaction with democracy and government
Authors: Harteveld Eelco , Kokkonen Andrej , Linde Jonas , Dahlberg Stefan 
Published: January 2021

AbstractPopulist radical right (PRR) parties are increasingly included in coalition governments across Western Europe. How does such inclusion affect satisfaction with democracy (SWD) in these societies? While some citizens will feel democracy has grown more responsive, others will abhor the inclusion of such controversial parties. Using data from the European Social Survey (2002–2018) and panel data from the Netherlands, we investigate how nativists’ and non-nativists’ SWD depends on mainstream parties’ strategies towards PRR parties. We show that the effect is asymmetrical: at moments of inclusion nativists become substantially more satisfied with democracy, while such satisfaction among non-nativists decreases less or not at all. This pattern, which we attribute to Easton’s ‘reservoir of goodwill’, that is, a buffer of political support generated by a track-record of good performance and responsiveness, can account for the seemingly contradictory increase in SWD in many Western European countries in times of populism.
Phospholipid dynamics in ex vivo lung cancer and normal lung explants
Authors: Lesko Julia , Triebl Alexander , Stacher-Priehse Elvira , Fink-Neuböck Nicole , Lindenmann Jörg , Smolle-Jüttner Freyja-Maria , Köfeler Harald C. , Hrzenjak Andelko , Olschewski Horst , Leithner Katharina 
Published: January 2021

AbstractIn cancer cells, metabolic pathways are reprogrammed to promote cell proliferation and growth. While the rewiring of central biosynthetic pathways is being extensively studied, the dynamics of phospholipids in cancer cells are still poorly understood. In our study, we sought to evaluate de novo biosynthesis of glycerophospholipids (GPLs) in ex vivo lung cancer explants and corresponding normal lung tissue from six patients by utilizing a stable isotopic labeling approach. Incorporation of fully 13C-labeled glucose into the backbone of phosphatidylethanolamine (PE), phosphatidylcholine (PC), and phosphatidylinositol (PI) was analyzed by liquid chromatography/mass spectrometry. Lung cancer tissue showed significantly elevated isotopic enrichment within the glycerol backbone of PE, normalized to its incorporation into PI, compared to that in normal lung tissue; however, the size of the PE pool normalized to the size of the PI pool was smaller in tumor tissue. These findings indicate enhanced PE turnover in lung cancer tissue. Elevated biosynthesis of PE in lung cancer tissue was supported by enhanced expression of the PE biosynthesis genes ETNK2 and EPT1 and decreased expression of the PC and PI biosynthesis genes CHPT1 and CDS2, respectively, in different subtypes of lung cancer in publicly available datasets. Our study demonstrates that incorporation of glucose-derived carbons into the glycerol backbone of GPLs can be monitored to study phospholipid dynamics in tumor explants and shows that PE turnover is elevated in lung cancer tissue compared to normal lung tissue.
A new precision medicine initiative at the dawn of exascale computing
Authors: Nussinov Ruth , Jang Hyunbum , Nir Guy , Tsai Chung-Jung , Cheng Feixiong 
Published: January 2021

AbstractWhich signaling pathway and protein to select to mitigate the patient’s expected drug resistance? The number of possibilities facing the physician is massive, and the drug combination should fit the patient status. Here, we briefly review current approaches and data and map an innovative patient-specific strategy to forecast drug resistance targets that centers on parallel (or redundant) proliferation pathways in specialized cells. It considers the availability of each protein in each pathway in the specific cell, its activating mutations, and the chromatin accessibility of its encoding gene. The construction of the resulting Proliferation Pathway Network Atlas will harness the emerging exascale computing and advanced artificial intelligence (AI) methods for therapeutic development. Merging the resulting set of targets, pathways, and proteins, with current strategies will augment the choice for the attending physicians to thwart resistance.
Microbial niche differentiation explains nitrite oxidation in marine oxygen minimum zones
Authors: Sun Xin , Frey Claudia , Garcia-Robledo Emilio , Jayakumar Amal , Ward Bess B 
Published: January 2021

Abstract
Nitrite is a pivotal component of the marine nitrogen cycle. The fate of nitrite determines the loss or retention of fixed nitrogen, an essential nutrient for all organisms. Loss occurs via anaerobic nitrite reduction to gases during denitrification and anammox, while retention occurs via nitrite oxidation to nitrate. Nitrite oxidation is usually represented in biogeochemical models by one kinetic parameter and one oxygen threshold, below which nitrite oxidation is set to zero. Here we find that the responses of nitrite oxidation to nitrite and oxygen concentrations vary along a redox gradient in a Pacific Ocean oxygen minimum zone, indicating niche differentiation of nitrite-oxidizing assemblages. Notably, we observe the full inhibition of nitrite oxidation by oxygen addition and nitrite oxidation coupled with nitrogen loss in the absence of oxygen consumption in samples collected from anoxic waters. Nitrite-oxidizing bacteria, including novel clades with high relative abundance in anoxic depths, were also detected in the same samples. Mechanisms corresponding to niche differentiation of nitrite-oxidizing bacteria across the redox gradient are considered. Implementing these mechanisms in biogeochemical models has a significant effect on the estimated fixed nitrogen budget.