bluuebunny/crossref_metadata_2025_split huggingface dataset:
The confluence of knowledge management and management control systems: A conceptual framework
Authors: Asiaei Kaveh , Bontis Nick , Zakaria Zarina 
Published: February 2020

PurposeThis study seeks to synthesize theories from the knowledge‐based view (KBV) of the firm and management control systems (MCS) to explore how organizations leverage MCS in order to support their knowledge management (KM) agenda.Design/methodology/approachThe core premise of the “fit‐as‐mediation” view holds that knowledge factors may trigger positive changes in the design and usage of certain organizational mechanisms. This, in turn, can expedite information processing and thereby deliver more value to organizations.FindingsDrawing upon the KBV of the firm and Simons' levers of control framework, the conceptual model of the study shows that the usage of particular organizational control systems, that is, the balanced use of MSC, can play a role in translating KM into improved performance. More precisely, the model indicates how KM is indirectly related to organizational performance through the mediating influence of the balanced use of MCS.Practical implicationsThe paper may provoke practical courses of action by highlighting the importance of using a balanced and comprehensive MCS in order to support KM strategies and initiatives.Originality/valueBased on a unique synthesis of the KBV and the fit‐as‐mediation notion of contingency view, this study provides new insights into the association between KM and organizational performance. This is the first study that introduces a mediating effect of the balanced use of MCS between KM and organizational performance.
Outcomes and Predictive Value of Post‐adjuvant Therapy PET/CT for Locally Advanced Oral Squamous Cell Carcinoma
Authors: Qian David C. , Magliocca Kelly R. , Aiken Ashley H. , Baugnon Kristen L. , Brandon David C. , Stokes William A. , McDonald Mark W. , Patel Mihir R. , Baddour Harry M. , Kaka Azeem S. , Steuer Conor E. , Saba Nabil F. , Shin Dong M. , Beitler Jonathan J. 
Published: February 2020

Objectives/HypothesisFor locally advanced oral squamous cell carcinoma (OSCC) treated by surgery and adjuvant therapy, consensus has yet to be reached on whether the optimal time to initiate surveillance positron emission tomography/computed tomography (PET/CT) scan is before or after adjuvant therapy. In this study, we characterize the utility of PET/CT scans obtained 3 months after adjuvant therapy.Study DesignPET/CT scans were obtained for 220 patients with stage III, IVA, or IVB OSCC who underwent resection followed by adjuvant radiotherapy or chemoradiotherapy.MethodsUsing the Neck Imaging Reporting and Data System, PET/CT scans were dichotomized as suspicious (primary or neck category ≥3, or distant lesion present) versus nonsuspicious. We then computed differences in locoregional progression, distant progression, and overall survival; positive predictive value (PPV), negative predictive value (NPV), sensitivity, and specificity; and success rate of salvage.ResultsSixty‐seven patients (30%) had suspicious PET/CT scans, which were significantly associated with local failure (hazard ratio [HR] 14.0, 95% confidence interval [CI] 7.3–26.6), distant failure (HR 18.4, 95% CI 9.6–35.3), and poorer overall survival (HR 9.5, 95% CI 5.0–17.9). Overall PPV, locoregional PPV, NPV, sensitivity, and specificity were 85%, 79%, 73%, 58%, and 92%, respectively. Among those with biopsy‐confirmed progression, 37 patients (65%) underwent salvage therapy; four (11%) were without evidence of disease at last follow‐up.ConclusionsFor locally advanced OSCC, PET/CT scan 3 months after adjuvant therapy is strongly predictive of disease recurrence and survival, demonstrating improved performance over postoperative imaging in previous studies. Following a suspicious post‐adjuvant therapy PET/CT scan, cure of locoregional recurrence is possible but unlikely.Level of Evidence4 Laryngoscope, 2020
Stoichiometric constraints on phytoplankton resource use efficiency in monocultures and mixtures
Authors: Frank Franziska , Danger Michael , Hillebrand Helmut , Striebel Maren 
Published: February 2020

AbstractA central concept for understanding the mechanisms linking diversity and primary production or more general, ecosystem functioning, is resource use efficiency (RUE). It quantifies the amount of biomass production over time relative to unit resource supplied, that is, represents a quota of matter use efficiency. Given anthropogenic alterations of biogeochemical cycles, the consequent changes in supply rate and especially supply ratio of nutrients will change. Using four species of freshwater phytoplankton, and their mixture, we asked how the RUE for nitrogen and phosphorus depends on the stoichiometry of resource supply and how this differs between single species and their mixture. We conducted a factorial laboratory experiment spanning 25 different nutrient supply treatments with differing absolute and relative nitrogen (N) and phosphorus (P) concentrations. N and P supply increased biomass production and decreased C : nutrient ratios and RUE for the respective nutrient, but always significantly affected by the supply of the respective other nutrient. Biomass peaked at molar N : P supply ratios above the Redfield ratio (18–22). Species tended to respond similarly to the resource gradients. Consequently, mixtures outperformed the component species only during early growth responses, but not regarding maximum biomass and RUE. Bioassays performed at the end of the main experiment revealed predominance of N‐limitation, but again strongly depending on the interaction between both nutrient gradients. Our study suggests that stoichiometric constraints of resource incorporation and RUE need to be accounted for when studying the response of phytoplankton to natural and anthropogenic variation in resource availability.
Shallow coral reef free ocean carbon enrichment: Novel in situ flumes to manipulate pCO2 on shallow tropical coral reef communities
Authors: Srednick Griffin , Bergman Jessica L. , Doo Steve S. , Hawthorn Myron , Ferree Jeffrey , Rojas Roberto , Arias Rogelio , Edmunds Peter J. , Carpenter Robert C. 
Published: February 2020

AbstractGiven the severe implications of climate change and ocean acidification (OA) for marine ecosystems, there is an urgent need to quantify ecosystem function in present‐day conditions to determine the impacts of future changes in environmental conditions. For tropical coral reefs that are acutely threatened by these effects, the metabolism of benthic communities provides several metrics suitable for this purpose, but the application of infrastructure to manipulate conditions and measure community responses is not fully realized. To date, most studies of the effects of OA on coral reefs have been conducted ex situ, and while greater ecological relevance can be achieved through free ocean carbon enrichment (FOCE) experiments on undisturbed areas of reef, such approaches have been deterred by technical challenges (e.g., spatial scale and duration, stable maintenance of conditions). In this study, we describe novel experimental infrastructure called shallow coral reef (SCoRe) FOCE to overcome these challenges and present data from a proof of concept application in Mo'orea, French Polynesia. Our objectives were to (1) implement an autonomous system that could be deployed kilometers from shore, (2) regulate the chemical (pCO2) and physical properties of seawater over undisturbed, shallow (∼2–5‐m depth) coral reef over multiple weeks, and (3) measure the metabolic response of the coral community to the treatment conditions. We describe the design, function, and application of the SCoRe FOCE, and present data demonstrating its efficacy. This infrastructure has great potential for advancing ecologically relevant studies of the effects of changing environmental conditions on coral reefs.
Diffusion model comparison identifies distinct tumor sub‐regions and tracks treatment response
Authors: McHugh Damien J. , Lipowska‐Bhalla Grazyna , Babur Muhammad , Watson Yvonne , Peset Isabel , Mistry Hitesh B. , Hubbard Cristinacce Penny L. , Naish Josephine H. , Honeychurch Jamie , Williams Kaye J. , O'Connor James P. B. , Parker Geoffrey J. M. 
Published: February 2020

PurposeMRI biomarkers of tumor response to treatment are typically obtained from parameters derived from a model applied to pre‐treatment and post‐treatment data. However, as tumors are spatially and temporally heterogeneous, different models may be necessary in different tumor regions, and model suitability may change over time. This work evaluates how the suitability of two diffusion‐weighted (DW) MRI models varies spatially within tumors at the voxel level and in response to radiotherapy, potentially allowing inference of qualitatively different tumor microenvironments.MethodsDW‐MRI data were acquired in CT26 subcutaneous allografts before and after radiotherapy. Restricted and time‐independent diffusion models were compared, with regions well‐described by the former hypothesized to reflect cellular tissue, and those well‐described by the latter expected to reflect necrosis or oedema. Technical and biological validation of the percentage of tissue described by the restricted diffusion microstructural model (termed %MM) was performed through simulations and histological comparison.ResultsSpatial and radiotherapy‐related variation in model suitability was observed. %MM decreased from a mean of 64% at baseline to 44% 6 days post‐radiotherapy in the treated group. %MM correlated negatively with the percentage of necrosis from histology, but overestimated it due to noise. Within MM regions, microstructural parameters were sensitive to radiotherapy‐induced changes.ConclusionsThere is spatial and radiotherapy‐related variation in different models’ suitability for describing diffusion in tumor tissue, suggesting the presence of different and changing tumor sub‐regions. The biological and technical validation of the proposed %MM cancer imaging biomarker suggests it correlates with, but overestimates, the percentage of necrosis.
Terms of engagement: Facebook and Twitter use among nonprofit human service organizations
Authors: Campbell David A. , Lambright Kristina T. 
Published: February 2020

AbstractThis study uses Lovejoy and Saxton's (2012) hierarchy of engagement to analyze how nonprofit human service organizations use Facebook and Twitter to engage stakeholders. Their framework has not been applied to this nonprofit subgroup, and most previous scholarship on this topic focuses on just one platform. We also contribute by drawing on organizational theory to better understand variation in the modes of engagement organizations emphasize. Based on our analysis, we add new subcategories to the hierarchy of engagement. In addition, we find that compared to other nonprofit subgroups examined in previous research, the organizations in our sample placed a greater emphasis on using social media messages to ask stakeholders to take action. We report only modest variations in how organizations were using Facebook and Twitter. Finally, according to our results, resource dependence and stewardship theories help explain the modes of engagement organizations prioritize.
Perspectives of older patients on the qualities which define a “good family nurse”: A qualitative study
Authors: Marcinowicz Ludmila , Taranta Ewa 
Published: February 2020

AbstractAimTo explore what the term “good family nurse” means to older patients.DesignA descriptive qualitative study design was used, and a purposive sampling method was adopted.MethodsSemi‐structured interviews were conducted with 21 patients aged 65 years and older who were receiving primary care in Bialystok (Poland). The interviews were recorded and then transcribed in verbatim. The data were analysed using content analysis. Data were collected between February 2017 and December 2018.ResultsWe identified six main categories of qualities that define a “good family nurse”. These are as follows: (a) personal traits and attributes (sex and individual characteristics and behaviours not directly related to nursing); (b) providing care (caring attitude and patient support); (c) communicating with the patient (the ability to listen and inform the patient); (d) professional competence (knowledge, professional experience and good technical skills); (e) ethical attitude (respect, patience and vocation); and (f) availability (the frequency and duration of home visits, organization of the doctor's appointments).
Shedding Light Onto the Nature of Iron Decorated Graphene and Graphite Oxide Nanohybrids for CO2 Conversion at Atmospheric Pressure
Authors: Owen Rhodri E. , Cortezon‐Tamarit Fernando , Calatayud David G. , Evans Enid A. , Mitchell Samuel I. J. , Mao Boyang , Palomares Francisco J. , Mitchels John , Plucinski Pawel , Mattia Davide , Jones Matthew D. , Pascu Sofia I. 
Published: February 2020

AbstractWe report on the design and testing of new graphite and graphene oxide‐based extended π‐conjugated synthetic scaffolds for applications in sustainable chemistry transformations. Nanoparticle‐functionalised carbonaceous catalysts for new Fischer Tropsch and Reverse GasWater Shift (RGWS) transformations were prepared: functional graphene oxides emerged from graphite powders via an adapted Hummer's method and subsequently impregnated with uniform‐sized nanoparticles. Then the resulting nanomaterials were imaged by TEM, SEM, EDX, AFM and characterised by IR, XPS and Raman spectroscopies prior to incorporation of Pd(II) promoters and further microscopic and spectroscopic analysis. Newly synthesised 2D and 3D layered nanostructures incorporating carbon‐supported iron oxide nanoparticulate pre‐catalysts were tested, upon hydrogen reduction in situ, for the conversion of CO2 to CO as well as for the selective formation of CH4 and longer chain hydrocarbons. The reduction reaction was also carried out and the catalytic species isolated and fully characterised. The catalytic activity of a graphene oxide‐supported iron oxide pre‐catalyst converted CO2 into hydrocarbons at different temperatures (305, 335, 370 and 405 °C), and its activity compared well with that of the analogues supported on graphite oxide, the 3‐dimensional material precursor to the graphene oxide. Investigation into the use of graphene oxide as a framework for catalysis showed that it has promising activity with respect to reverse gas water shift (RWGS) reaction of CO2 to CO, even at the low levels of catalyst used and under the rather mild conditions employed at atmospheric pressure. Whilst the γ‐Fe2O3 decorated graphene oxide‐based pre‐catalyst displays fairly constant activity up to 405 °C, it was found by GC‐MS analysis to be unstable with respect to decomposition at higher temperatures. The addition of palladium as a promoter increased the activity of the iron functionalised graphite oxide in the RWGS. The activity of graphene oxide supported catalysts was found to be enhanced with respect to that of iron‐functionalised graphite oxide with, or without palladium as a promoter, and comparable to that of Fe@carbon nanotube‐based systems tested under analogous conditions. These results display a significant step forward for the catalytic activity estimations for the iron functionalised and rapidly processable and scalable graphene oxide. The hereby investigated phenomena are of particular relevance for the understanding of the intimate surface morphologies and the potential role of non‐covalent interactions in the iron oxide‐graphene oxide networks, which could inform the design of nano‐materials with performance in future sustainable catalysis applications.
Robust global controller design for discrete‐time descriptor systems with multiple time‐varying delays
Authors: Mobayen Saleh , Bayat Farhad , Omidvar Hossein , Fekih Afef 
Published: February 2020

SummaryDescriptor systems are ubiquitous in many complex practical systems including spacecraft, electrical networks, economic systems, robotic, vibrational, and structural systems. Time delays are ubiquitous in those complex systems. If not addressed properly at the control design stage, they will result in singularities such as oscillation, instability, degraded performance. This article proposes a novel linear matrix inequality (LMI)‐based global sliding mode control (GSMC) approach for uncertain discrete‐time descriptor systems with multiple time‐varying delays. Strict LMI conditions are established based on free‐weighting matrices and the Lyapunov‐Krasovskii functional to guarantee admissible closed‐loop dynamics, that is, regular, causal, and stable. The sufficient condition for the asymptotic stability of the sliding mode dynamics is obtained based on the Lyapunov stability theorem and LMI constraint. The GSMC approach is then formulated based on a global sliding surface to ensure robust performance of the closed‐loop system against parametric uncertainties and time delays, while eliminating the reaching phase. The global sliding surface ensures robust performance without the need for a reaching phase, thus establishing sliding around the surface right from the beginning and reducing the control effort. The effectiveness and validity of the proposed approach is assessed using a numerical example.
Developmental Trajectories of Phonological Information Processing in Upper Elementary Students With Reading or Spelling Disabilities
Authors: Schmidt Claudia , Brandenburg Janin , Busch Jenny , Büttner Gerhard , Grube Dietmar , Mähler Claudia , Hasselhorn Marcus 
Published: February 2020

AbstractDeficits in phonological information processing in upper elementary students with specific learning disabilities in reading or spelling may increase, decrease, or remain stable over time. The authors examined the development of phonological processing longitudinally in 209 students (109 with learning disabilities and 100 typically achieving; n = 127 boys) in Germany, from grade 3 to grade 5 (ages 8–11; mean age at recruitment = 8 years 6.78 months, SD = 5.39 months). Latent change score models revealed that the development of rapid automatized naming was best described as a decreasing deficit, whereas a persistent deficit in phonological awareness was observed. Differences between students with and without learning disabilities regarding the phonological loop increased over time. Further, there were no developmental differences as a function of reading versus spelling deficits. Theoretical and practical implications are discussed.
Phosphodiesterase inhibitors roflumilast and vardenafil prevent sleep deprivation‐induced deficits in spatial pattern separation
Authors: Heckman Pim R. A. , Roig Kuhn Femke , Raven Frank , Bolsius Youri G. , Prickaerts Jos , Meerlo Peter , Havekes Robbert 
Published: February 2020

AbstractSleep deprivation (SD) is known to impair hippocampus‐dependent memory processes, in part by stimulating the phosphodiesterase (PDE) activity. In the present study, we assessed in mice whether SD also affects spatial pattern separation, a cognitive process that specifically requires the dentate gyrus (DG) subregion of the hippocampus. Adult male mice were trained in an object pattern separation (OPS) task in the middle of the light phase and then tested 24 hr thereafter. In total, we conducted three studies using the OPS task. In the first study, we validated the occurrence of pattern separation and tested the effects of SD. We found that 6 hr of SD during the first half of the light phase directly preceding the test trial impaired the spatial pattern separation performance. As a next step, we assessed in two consecutive studies whether the observed SD‐induced performance deficits could be prevented by the systemic application of two different PDE inhibitors that are approved for human use. Both the PDE4 inhibitor roflumilast and PDE5 inhibitor vardenafil successfully prevented SD‐induced deficits in spatial pattern separation. As a result, these PDE inhibitors have clinical potential for the prevention of memory deficits associated with loss of sleep.
Generation Y in der Chirurgie – der Konkurrenzkampf um Talente in Zeiten des Nachwuchsmangels
Authors: Schneider Kristian Nikolaus , Masthoff Max , Gosheger Georg , Schopow Nikolas , Theil Jan Christoph , Marschall Bernhard , Zehrfeld Jürgen 
Published: February 2020

ZusammenfassungHintergrundChirurgische Fachdisziplinen kämpfen mit einem kritischen und sich zuspitzenden Nachwuchsproblem. Potenzielle Berufsanfänger zählen zur Generation Y, die Chefärzte und Personalabteilungen regelmäßig vor große Herausforderungen stellt. Ziel dieser Arbeit ist die Analyse verschiedener Maßnahmen der Personalakquise unter Berücksichtigung erhobener Motivationsfaktoren junger Medizinstudenten.Material und MethodenUmfrage unter Medizinstudenten des 1. und 9. Fachsemesters (FS) einer medizinischen Fakultät zu individuellen Motivationsfaktoren, der angestrebten Facharztweiterbildung und der gesammelten Berufserfahrung in der Chirurgie.ErgebnisseErgebnisse von 179 der 269 befragten Medizinstudenten (66,5 %) konnten ausgewertet werden. Das Interesse an einer chirurgischen Facharztweiterbildung ist im 1. FS hoch (21 %) – fällt jedoch bis zum 9. FS deutlich ab (13 %;p = 0,23). Medizinstudenten, die im 9. FS „Aufstieg und Anerkennung“ gegenüber „flexible Arbeitszeiten“ präferieren, zeigen ein signifikant höheres Interesse an einer chirurgischen Weiterbildung (p = 0,022). Erworbene chirurgische Berufserfahrung wird mit einer durchschnittlichen Schulnote von 2+ bewertet.SchlussfolgerungDas hohe Grundinteresse an einer chirurgischen Facharztweiterbildung zu Studienbeginn ist ein Wettbewerbsvorteil der Chirurgie. Die vielfältigen Rekrutierungsanstrengungen setzen jedoch oft erst gegen Ende des Studiums an. Zur langfristigen Nachwuchsbindung haben sich insbesondere frühzeitige Programme mit „Hands-on“-Charakter im chirurgischen Kernarbeitsbereich – dem Operationssaal – als erfolgreich erwiesen.
A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes
Authors:   Mouse Phenome Database Team, Kollmus Heike , Fuchs Helmut , Lengger Christoph , Haselimashhadi Hamed , Bogue Molly A. , Östereicher Manuela A. , Horsch Marion , Adler Thure , Aguilar-Pimentel Juan Antonio , Amarie Oana Veronica , Becker Lore , Beckers Johannes , Calzada-Wack Julia , Garrett Lillian , Hans Wolfgang , Hölter Sabine M. , Klein-Rodewald Tanja , Maier Holger , Mayer-Kuckuk Philipp , Miller Gregor , Moreth Kristin , Neff Frauke , Rathkolb Birgit , Rácz Ildikó , Rozman Jan , Spielmann Nadine , Treise Irina , Busch Dirk , Graw Jochen , Klopstock Thomas , Wolf Eckhard , Wurst Wolfgang , Yildirim Ali Önder , Mason Jeremy , Torres Arturo , Balling Rudi , Mehaan Terry , Gailus-Durner Valerie , Schughart Klaus , Hrabě de Angelis Martin 
Published: February 2020

AbstractThe collaborative cross (CC) is a large panel of mouse-inbred lines derived from eight founder strains (NOD/ShiLtJ, NZO/HILtJ, A/J, C57BL/6J, 129S1/SvImJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ). Here, we performed a comprehensive and comparative phenotyping screening to identify phenotypic differences and similarities between the eight founder strains. In total, more than 300 parameters including allergy, behavior, cardiovascular, clinical blood chemistry, dysmorphology, bone and cartilage, energy metabolism, eye and vision, immunology, lung function, neurology, nociception, and pathology were analyzed; in most traits from sixteen females and sixteen males. We identified over 270 parameters that were significantly different between strains. This study highlights the value of the founder and CC strains for phenotype-genotype associations of many genetic traits that are highly relevant to human diseases. All data described here are publicly available from the mouse phenome database for analyses and downloads.