bluuebunny/crossref_metadata_2025_split huggingface dataset:
Left atrial appendage (LAA) electrical isolation by Maze‐like catheter substrate modification in presence of LAA‐occluder device: A case report
Authors: Zanchi Simone , Bianchini Lorenzo , Bordignon Stefano , Bologna Fabrizio , Tohoku Shota , Chen Shaojie , Chun Julian K. R. , Schmidt Boris 
Published: July 2020

AbstractMaze‐like linear substrate modification in atrial fibrillation patients nonresponders to pulmonary vein isolation represents a feasible technique to gain left atrial appendage electrical isolation even in the presence of a Watchman occluder device.
Collapsing focal segmental sclerosis in an HIV‐negative patient
Authors: Padala Sandeep Anand , Birkelo Bethany , Mohammed Azeem , Kapoor Rajan , Mulloy Laura , Rawla Prashanth 
Published: July 2020

AbstractCollapsing focal segmental glomerulosclerosis (FSGS) is classically seen in HIV‐infected patients and carries a dismal prognosis. It can also occur in HIV‐negative patients in which case, early aggressive treatment with glucocorticoids may be helpful with improvement in both proteinuria and renal function.
Crop rotation, irrigation system, and irrigation rate on cotton yield in southwestern Georgia
Authors: Sorensen Ronald B. , Lamb Marshall C. , Butts Christopher L. 
Published: July 2020

AbstractLong‐term yield data would be useful for determining crop rotation, irrigation system selection, and irrigation rate for maximum production and economic sustainability. Research was conducted at the USDA–ARS National Peanut Research Laboratory's Multi‐crop Irrigation Research Farm in Shellman, GA (84°36″ W, 30°44″ N), on a Greenville fine sandy loam (a fine, kaolinitic, thermic Rhodic Kandiudult) soil with 0–2% slope. This long‐term study (2001–2013) compared three irrigation systems, three cotton (Gossypium hirsutum L.) crop rotations, and various irrigation rates on cotton lint yield and quality factors. Irrigation systems were sprinkler, subsurface drip (SSDI), and shallow subsurface drip (S3DI) irrigation compared with a dryland control. Irrigation rates were 100, 66, 50, 33, and 0% of estimated water use. Crop rotations were (a) cotton–corn (Zea mays L.)–peanut (Arachis hypogaea L.), (b) cotton–cotton–peanut; and (c) cotton–peanut–cotton. There was no difference in cotton yield by crop rotation. Sprinkler and S3DI systems had greater lint yield than the SSDI system at the 100% irrigation level when averaged across all years and rotations. Lint yield tended to be lower in high rainfall years without respect to irrigation system. Irrigation increased lint yield by an average 10% when rainfall was less than average. All fiber quality factors were within acceptable ranges without any value discounts across years, rotation, or irrigation system. Irrigation system selection should not be based entirely on long‐term yield information but also on field size, system installation cost, irrigation system controls, and crop management.
New Reactivity Patterns in 3H‐Phosphaallene Chemistry [Aryl‐P=C=C(H)‐tBu]: Hydroboration of the C=C Bond, Deprotonation and Trimerisation
Authors: Tendyck Jonas C. , Hepp Alexander , Würthwein Ernst‐Ulrich , Uhl Werner 
Published: July 2020

Abstract3H‐Phosphaallenes, R−P=C=C(H)C−R’ (3), are accessible in a multigram scale on a new and facile route and show a fascinating chemical reactivity. BH3(SMe2) and 3 a (R=Mes*, R’=tBu) afforded by hydroboration of the C=C bonds of two phosphaallene molecules an unprecedented borane (7) with the B atom bound to two P=C double bonds. This compound represents a new FLP based on a B and two P atoms. The increased Lewis acidity of the B atom led to a different reaction course upon treatment of 3 a with H2B‐C6F5(SMe2). Hydroboration of a C=C bond of a first phosphaallene is followed in a typical FLP reaction by the coordination of a second phosphaallene molecule via B−C and P−B bond formation to yield a BP2C2 heterocycle (8). Its B−P bond is short and the B‐bound P atom has a planar surrounding. Treatment of 3 a with tBuLi resulted in deprotonation of the β‐C atom of the phosphaallene (9). The Li atom is bound to the P atom as demonstrated by crystal structure determination, quantum chemical calculations and reactions with HCl, Cl‐SiMe3 or Cl‐PtBu2. The thermally unstable phosphaallene Ph−P=C=C(H)‐tBu gave a unique trimeric secondary product by P−P, P−C and C−C bond formation. It contains a P2C4 heterocycle and was isolated as a W(CO)4 complex with two P atoms coordinated to W (15).
Long‐Range LMCT Coupling in EuIII Coordination Polymers for an Effective Molecular Luminescent Thermometer**
Authors: Kitagawa Yuichi , Kumagai Marina , Ferreira da Rosa Pedro Paulo , Fushimi Koji , Hasegawa Yasuchika 
Published: July 2020

AbstractA design for an effective molecular luminescent thermometer based on long‐range electronic coupling in lanthanide coordination polymers is proposed. The coordination polymers are composed of lanthanide ions EuIII and GdIII, three anionic ligands (hexafluoroacetylacetonate), and a chrysene‐based phosphine oxide bridges (6,12‐bis(diphenylphosphoryl)chrysene). The zig‐zag orientation of the single polymer chains induces the formation of packed coordination structures containing multiple sites for CH‐F intermolecular interactions, resulting in thermal stability above 350 °C. The electronic coupling is controlled by changing the concentration of the GdIII ion in the EuIII‐GdIII polymer. The emission quantum yield and the maximum relative temperature sensitivity (Sm) of emission lifetimes for the EuIII‐GdIII polymer (Eu:Gd=1:1, Φtot=52 %, Sm=3.73 % K−1) were higher than those for the pure EuIII coordination polymer (Φtot=36 %, Sm=2.70 % K−1), respectively. Enhanced temperature sensing properties are caused by control of long‐range electronic coupling based on phosphine oxide with chrysene framework.
Exo‐Cyclization: Intermolecular Methylene Transfer Sequence in Au‐Catalyzed Reactions of O‐Homopropargylic Oximes
Authors: Nakamura Itaru , Hirayama Arinobu , Gima Shinya , Terada Masahiro 
Published: July 2020

AbstractThe Au‐catalyzed reactions of O‐homopropaylic oximes afforded the 3‐alkenylated isoxazolines in good to high yields. The mechanistic studies suggest that the reaction proceeds through an exo‐cyclization followed by intermolecular methylene group transfer. In addition, oligomeric species of the starting material were observed in the reaction mixture by mass spectra, supporting our proposed mechanism, which proceeds through a repeated intermolecular C−C bond forming process.
Phospholipid Cyclosporine Prodrugs Targeted at Inflammatory Bowel Disease (IBD) Treatment: Design, Synthesis, and in Vitro Validation
Authors: Manda Jagadeesh Nagendra , Markovic Milica , Zimmermann Ellen M. , Ben‐Shabat Shimon , Dahan Arik , Aponick Aaron 
Published: July 2020

AbstractNovel phospholipid (PL)‐cyclosporine conjugates were prepared and studied as potential prodrugs for inflammatory bowel disease (IBD). Our approach relies on phospholipase A2 (PLA2), which is overexpressed in the inflamed intestinal tissues, as the prodrug activator to potentially release cyclosporine at the site of inflammation. PL‐cyclosporine prodrug conjugates with methylene linkers of various lengths between the sn‐2 position of the PL and cyclosporine were synthesized and evaluated for in vitro activation. Surprisingly, despite previous work indicating that conjugates with six methylene linkers between the lipid and drug would suffer rapid enzymatic hydrolysis, with cyclosporine this was not observed. However, compounds with longer linkers (n=10, 12 methylene units) display complete release of the drug by PLA2‐catalyzed hydrolysis, thus demonstrating the importance and profound impact of structural fine‐tuning. This study represents a proof‐of‐concept for our hypothesis and a first step towards a truly targeted IBD treatment with cyclosporine that could be administered throughout the GI tract.
Design of a reversible structure for memory in quantum‐dot cellular automata
Authors: Salimzadeh Fereshteh , Heikalabad Saeed Rasouli , Gharehchopogh Farhad Soleimanian 
Published: July 2020

SummaryComplementary metal oxide semiconductor (CMOS) technology has limitations in reducing the area and size of circuits. The disadvantages of this technology include high power consumption and temperature problems. Quantum‐dot cellular automata (QCA) is a new technology that can overcome these shortcomings. Reversible logic is technology used to reduce the power loss in QCA. QCA can be used to design memories that require high operating speed. In this paper, we propose a structure for the reversible memory in QCA. The proposed structure utilizes three‐layer technology, which has a significant impact on circuit size reduction. The proposed structure for the reversible memory has 63% improvement in cell number, a 75% improvement in area occupancy, and a 60% reduction in delay compared to the previous best structure.
A new approach for service migration in cloud‐based e‐commerce using an optimization algorithm
Authors: Huang Lixia , Abnoosian Karlo 
Published: July 2020

SummaryService‐oriented architecture (SOA) has a crucial role in backing productive cloud services. Also, the vast spread of the theoretical notion of diverse businesses (like e‐commerce) into the actual use has been recently applied by cloud computing. The service functionality could be affected by overfilling of the network traffic because of the broadly dispersed nature of e‐commerce in clouds—a key challenge for immediate jobs. Throughout the last decade, a vast range of applications or large‐scale operators has increasingly attracted to migrate the services in clouds. An effective method for accessing the applications throughout standard business hours is continually moving virtual machine containers from one data center to another. Now, with the commonness of cloud computing, many applications have been moved to the cloud fully/partly. It can be handled through the migration of cloud services to diverse platforms in a way that minimizes the communication cost of e‐commerce. As this issue has an NP‐hard nature, in the present article, we present an automatic smart service migration outline through the ant colony optimization (ACO) algorithm on cloud‐oriented e‐commerce. In the presented model, we use the ACO algorithm to take the finest (near‐optimal) service migration decisions. Based on the obtained results, the proposed technique has the optimal number of migrations compared to the existing models.
Impact of co‐channel interference on performance of dual‐hop wireless ad hoc networks over α−μ fading channels
Authors: Jwaifel Arwa M. J. , Ghareeb Ibrahim , Shaltaf Samir 
Published: July 2020

SummaryIn this work, we investigate the performance of a dual‐hop cooperative network over α−μ fading channels with the presence of co‐channel interference (CCI) at both the relay and destination nodes. Amplify‐and‐forward (AF) relaying is considered in the relay node. The upper bound of the signal‐to‐interference‐plus‐noise ratio (SINR) of the dual‐hop relay link is used to determine the system performance. The probability density function (PDF) and the cumulative distribution function (CDF) of the upper bound of the SINR are analyzed. The system performance is determined in terms of the outage and error probabilities. Numerical results are used to present the performance analysis of the system.
Generation of Pecam1 endothelial specific dual reporter mouse model
Authors: Hu Donghua , Zhang Lu , Yang Fan , Chen Fuxue , Li Deqiang , Cai Chen‐Leng 
Published: July 2020

SummaryEndothelial cells are specialized epithelium lining the interior surface of vessels and play fundamental roles in angiogenesis, vascular permeability, and immune response. To identify endothelial cells in vivo, we constructed a Pecam1nlacZ‐H2B‐GFP/+ knock‐in mouse model in which the endothelial cells are labeled by nuclear LacZ (nlacZ) expression. When Pecam1nlacZ‐H2B‐GFP/+ mice are bred with germline Cre deleter mice, Pecam1H2B‐GFP/+ line is created with native nuclear GFP (H2B‐GFP) expression in the endothelium of various organs. This dual reporter mouse provides us with a powerful genetic tool for definitive identification of endothelial cells and monitoring this important cell population throughout development, homeostasis, and disease conditions in mammals.
Exploration of heat and momentum transfer in turbulent mode during the precooling process of fruit
Authors: Nalbandi Habibeh , Seiiedlou Sadegh 
Published: July 2020

AbstractDeveloping a simulator is a prevalent method for the study of any process in which various phenomena occur simultaneously, such as the precooling process; it is also necessary in package designing. During the precooling process of fruit and in the case of large packages at high airflow rates, the flow regime inside the packages is turbulent, which is in most studies assumed to be a laminar flow that causes low prediction accuracy. In the present study, a mathematical model consisting of heat and momentum transfer in the case of a transient and a k‐ɛ turbulence model, respectively, was developed in the precooling process of fruits. Two packages and two airflow rates were used to validate the model. The results demonstrate that the turbulence‐model‐based simulation of the precooling was carried out with a lower element number, within a shorter time, and with a satisfactory accuracy (R2 > .93866 & RMSE < 0.62). The model could predict the air movement between the fruit and consequently the heat transfer between the air and fruit. The simulator could be utilized to package designing and predicting the precooling time at the industrial scale to prevent the over‐cooling of fruits and reduce energy consumption. Based on the results, the precooling of apples in the commercial package was conducted in both experimental and simulation methods with high heterogeneity lasting 268 and 520 min at airflow rates of 0.5 and 1.5 L s−1 kg−1p, respectively. By using the developed simulator, the new package was designed for apple through which the cooling time and heterogeneity decreased 48% and 35%, respectively, as compared with those obtained in the commercial package.
Digenic inheritance of MSH6 and MUTYH variants in familial colorectal cancer
Authors: Schubert Stephanie A. , Ruano Dina , Tiersma Yvonne , Drost Mark , de Wind Niels , Nielsen Maartje , van Hest Liselotte P. , Morreau Hans , de Miranda Noel F. C. C. , van Wezel Tom 
Published: July 2020

AbstractWe describe a family severely affected by colorectal cancer (CRC) where whole‐exome sequencing identified the coinheritance of the germline variants encoding MSH6 p.Thr1100Met and MUTYH p.Tyr179Cys in, at least, three CRC patients diagnosed before 60 years of age. Digenic inheritance of monoallelic MSH6 variants of uncertain significance and MUTYH variants has been suggested to predispose to Lynch syndrome‐associated cancers; however, cosegregation with disease in the familial setting has not yet been established. The identification of individuals carrying multiple potential cancer risk variants is expected to rise with the increased application of whole‐genome sequencing and large multigene panel testing in clinical genetic counseling of familial cancer patients. Here we demonstrate the coinheritance of monoallelic variants in MSH6 and MUTYH consistent with cosegregation with CRC, further supporting a role for digenic inheritance in cancer predisposition.
Access to preventive care services and stage at diagnosis in head and neck cancer
Authors: Farquhar Douglas R. , Lenze Nicholas R. , Masood Maheer M. , Divaris Kimon , Tasoulas Jason , Blumberg Jeffrey , Lumley Catherine , Patel Samip , Hackman Trevor , Weissler Mark C. , Yarbrough Wendell , Zanation Adam M. , Olshan Andrew F. 
Published: July 2020

AbstractBackgroundDecreased access to preventive care services has been proposed as a mechanism for the association between low socioeconomic status (SES) and advanced stage at diagnosis in patients with head and neck squamous cell carcinoma (HNSCC).MethodsRetrospective analysis of patients diagnosed with HNSCC in North Carolina between 2002 and 2006.ResultsA total of 1108 patients with HNSCC were included in the study. In the multivariable analysis, use of annual routine dental services (OR 0.7, 95% CI 0.5‐0.9) and colonoscopy in the past 10 years (OR 0.7, 95% CI 0.5‐0.9) were associated with lower odds of advanced T stage at diagnosis. Having no insurance (OR 1.8, 95% CI 1.1‐2.9), an income <$20 000 (OR 1.6 95% CI 1.03‐2.6), and >10 pack‐years tobacco use (OR 1.5, 95% CI 1.04‐2.2) were associated with advanced T stage at diagnosis.ConclusionUse of preventive care services and SES independently predict stage at diagnosis in HNSCC.
Chiral α‐Amino Acid‐Based NMR Solvating Agents
Authors: Nemes Anikó , Csóka Tamás , Béni Szabolcs , Garádi Zsófia , Szabó Dénes , Rábai József 
Published: July 2020

AbstractFour new chiral α‐(nonafluoro‐tert‐butoxy)carboxylic acids were synthesized from naturally occurring α‐amino acids (alanine, valine, leucine and isoleucine, respectively), and tested in 1H‐ and 19F‐NMR experiments as chiral NMR shift reagents. The NMR studies were carried out at room temperature, using CDCl3 and C6D6 as solvents, and (RS)‐α‐phenylethylamine and (RS)‐α‐(1‐naphthyl)ethylamine as racemic model compounds. To demonstrate the applicability of the reagents, the racemic drugs ketamine and prasugrel were also tested.
What is the normal range of obstetric shock index in the immediate postpartum period in a low‐resource setting?
Authors: Nwafor Johnbosco I. , Obi Chuka N. , Onuorah Olisah E. , Onwe Blessing I. , Ibo Chukwunenye C. , Onuchukwu Victor U. 
Published: July 2020

AbstractObjectiveTo determine the normal range of shock index (SI), blood pressure (BP), mean arterial pressure (MAP) and heart rate (HR) among postpartum women in a low‐resource setting.MethodsIn a prospective cohort study, vital signs were recorded 1 hour after delivery among postpartum women with normal blood loss who delivered in Abakaliki, Nigeria, from April to July 2019.ResultsAmong 225 women, the median (95% reference range) was 120 (100–155.8), 70 (60–94), and 90 (66.5–116.6) mm Hg for systolic BP, diastolic BP, and MAP, respectively; 82 (65–102) bpm for HR; and 0.69 (0.48–0.89) for SI. The upper SI limit of 0.89 supported the current value of 0.9 as the upper limit; however, the lower SI limit of 0.48 corresponded to the current lower limit for a non‐obstetric population (0.5). The SI of more than half of the study women (n=126; 56.0%) was within the normal range for non‐obstetric women (0.5–0.7).ConclusionAlthough hemodynamic changes in pregnancy widen the SI range, 56.0% of women maintained SI within the non‐obstetric reference range. In low‐resource settings, the current normal obstetric SI range of 0.7–0.9 should be revised to 0.5–0.9 to accommodate this lower threshold.
Are high levels of religiosity inconsistent with a high valuation of science? Evidence from the United States, China and Iran
Authors: Payir Ayse , Davoodi Telli , Cui Kelly Yixin , Clegg Jennifer M. , Harris Paul L. , Corriveau Kathleen 
Published: July 2020

We asked whether high levels of religiosity are inconsistent with a high valuation of science. We explored this possibility in three countries that diverge markedly in the relation between the state and religion. Parents in the United States (n = 126), China (n = 234) and Iran (n = 77) completed a survey about their personal and parental stance towards science. The relation between religiosity and the valuation of science varied sharply by country. In the U.S. sample, greater religiosity was associated with a lower valuation of science. A similar but weaker negative relation was found in the Chinese sample. Parents in the Iranian sample, by contrast, valued science highly, despite high levels of religiosity. Given the small size of our United States and Iranian samples, and the non‐probabilistic nature of our samples in general, we caution readers not to generalise our findings beyond the current samples. Despite this caveat, these findings qualify the assumption that religiosity is inconsistent with the valuation of science and highlight the role of sociocultural context in shaping adults' perception of the relation between religion and science.
Reforms in the irrigation sector of India
Authors: Vohra K. , Franklin M.L. 
Published: July 2020

AbstractIndia has taken up an ambitious goal to double the average income of agricultural households from 2015 to 2022. This mammoth task requiring a sharp accelerated annual growth of over 10% would have to harness all possible sources of growth within as well as outside the agricultural sector and will need strong inclusive measures in the irrigation sector such as water productivity, participatory irrigation management, water conservation, agricultural productivity, etc.Improper water management at the farm level leads to inefficient use of water and inequitable distribution with the tail‐end farmer often not getting water. Though an irrigation potential of 112 Mha (million hectares) has been created against an ultimate potential of 140 Mha, the utilization is only 93 Mha. Moreover, efficiency of water use in irrigation in India is about 30% to 40%. Emphasis now has to shift to resourceful management of water to meet the food grain demand of 450 million tonnes (MT) by 2050 against the present food grain production of 278 MT.This paper highlights the various steps taken by the Government of India, various state governments, non‐governmental organizations, etc. in reforming the irrigation sector of the country.
Front Cover: Implantable self‐aligning fiber‐optic optomechanical devices for in vivo intraocular pressure‐sensing in artificial cornea
Authors: Hui Pui‐Chuen , Shtyrkova Katia , Zhou Chengxin , Chen Xiaoniao , Chodosh James , Dohlman Claes H. , Paschalis Eleftherios I. 
Published: July 2020

AbstractThis work addresses an unmet clinical need, that of glaucoma monitoring through intraocular pressure (IOP) interrogation in patients with artificial corneas (keratoprost hesis). We demonstrate direct integration of a low‐drift, fiber‐optic Fabry‐Perot pressure sensor embedded in the keratoprosthesis via rapid, non‐contact micromagnetic fiber alignment. IOP interrogation is achieved by using white‐light interferometry, which provides sub‐mmHg IOP sensitivity.Further details can be found in the article by Pui‐Chuen Hui, Katia Shtyrkova, Chengxin Zhou, et al. (e202000031).
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