bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initial clinical experience with VersaCross transseptal system for transcatheter mitral valve repair
Authors: Sayah Neila , Simon Francois , Garceau Patrick , Ducharme Anique , Basmadjian Arsene , Bouchard Denis , Pellerin Michel , Bonan Raoul , Asgar Anita W. 
Published: November 2020

AbstractObjectivesThe aim of this study is to describe the initial experience with versacross transseptal (TS) system for transseptal puncture for the transcatheter mitral valve repair using the MitraClip device.BackgroundTranseptal puncture is a key step in transcatheter mitral valve repair (MVR) and the use of the VersaCross system comprised of a sheath, a dilator and a radiofrequency wire has not been previously described.MethodsProspective single center study of consecutive patients undergoing transcatheter mitral valve repair with the MitraClip device were included. Targeted TS puncture was performed under transesophageal echocardiographic (TEE) guidance. Baseline demographics, procedural characteristics, and major adverse procedural events were collected.ResultsTwenty‐five consecutive patients underwent transseptal puncture using the VersaCross TS system. Transseptal puncture was successful in 100% of patients. The mean time for TS puncture was 3 3 ± 1.6 min with no major adverse procedural events. The mean time from insertion of the VersaCross system to insertion of the MitraClip guide catheter was 3.8 ± 3.0 minutes.ConclusionThe VersaCross TS system was successful in all patients for MitraClip procedure with no adverse procedural events and may be associated with increased procedural efficiency.
Transcatheter mitral valve thrombosis: A case report and literature review
Authors: Alarfaj Mohammad , Jain Tushina , Krepp Joseph 
Published: November 2020

AbstractTranscatheter mitral valve replacement (TMVR) is an exciting alternative therapy for complex patients with mitral valve disease. Experience with TMVR is new and there is a lot yet to discover about their durability, long‐term outcomes, and complications including mitral transcatheter heart valve (THV) thrombosis. Many factors have been speculated to increased risk of THV thrombosis. Here, we report a case of a 72‐year‐old woman who developed mitral THV thrombosis after undergoing TMVR for severe mitral regurgitation with mitral annular calcification. We reviewed 42 TMVR papers with 1,484 patients, including 60 with mitral THV thrombosis. We discussed the most common strategies used for mitral THV thromboprophylaxis and treatment.
Thyroid angiosarcoma (TAS) — A rare diagnosis not to be missed
Authors: Kehagias Dimitrios , Kostopoulou Eirini , Ravazoula Panagiota , Panagopoulos Konstantinos 
Published: November 2020

AbstractRaising awareness about primary TAS, a rare and aggressive mesenchymal tumor, is important so that early diagnosis and undelayed radical surgery along with complementary radiation are possible. Extending the existing knowledge on the course and final outcome of the disease may help identify the best treatment approach to improve survival.
Succinic semialdehyde dehydrogenase deficiency presenting with central hypothyroidism
Authors: Alghamdi Malak Ali , Alkhamis Waleed H. , Jamjoom Dima Z. , Al Khalifah Reem , Alshammari Nawaf Rahi , Alsumaili Khalid , Arold Stefan T. 
Published: November 2020

AbstractCentral hypothyroidism might be another clinical sign of SSADH deficiency which prompts urinary organic acid screening for GHB in central hypothyroidism patients. Studies on GABA and thyroid hormone interaction might be a concept of a new therapy.
Two Challenging Cases with COVID heart
Authors: Asadian Sanaz , Hosseini Leila , Maadani Mohsen , Jahanshahi Bahareh , Rezaeian Nahid 
Published: November 2020

AbstractCOVID‐19 affects the heart through various pathways. It can increase thrombotic complications that ultimately lead to myocardial infarction even in patients without a history of underlying heart disease.
Carbamazepine‐induced Stevens‐Johnson syndrome in a patient with history of methotrexate‐induced mast cell activation syndrome
Authors: Zaalouk Tamer Mohamed , Bitar Zouheir Ibrahim , Maadarani Ossama Sajeh , Elhabibi Mohamed Elsayed 
Published: November 2020

AbstractStevens‐Johnson syndrome (SJS) is serious conditions that happen as a result of infection, side effects to medications, or unknown etiology. Carbamazepine is one of the common medications that can cause SJS. Good history taking is crucial if treatment with carbamazepine is clinically indicated. We would like to alert all physicians that carbamazepine should be avoided in any patient with a previous history of drug reaction such as mast cell activation syndrome.
Pathophysiological aspects of posterior reversible encephalopathy syndrome in two peritoneal‐dialyzed children
Authors: Keller Tamara , Wille David‐Alexander , Laube Guido F. 
Published: November 2020

AbstractHypotension, blood pressure fluctuation, and endothelial impairment indicate possible additive pathophysiological aspects in the development of posterior reversible encephalopathy syndrome in children on peritoneal dialysis.
Four narrow dental implants and conventionally cast bar‐supported removable hybrid acrylic complete denture as a therapeutic modality for terminal dentition
Authors: Alfarsi Mohammed A. , Shaik Sharaz 
Published: November 2020

AbstractThe report portrays four narrow implants and cast bar‐supported removable hybrid acrylic complete dentures and other terminal dentition treatment options in the maxilla. The therapeutic module could be efficient and satisfactory to patients.
Characterization of a New Structured Packing by Computational Fluid Dynamics
Authors: Hassanvand Amin , Esmaeili-Faraj Seyyed Hamid , Moghaddam Mojtaba Saei , Moradi Rasoul 
Published: November 2020

AbstractThe novel wire gauze structured packing PACK‐1300Y with high specific surface area was characterized by computational fluid dynamics. The main features of PACK‐1300Y were investigated including the dry and wet pressure drop as well as the height equivalent to a theoretical plate (HETP). Moreover, the flow structure of this packing was described via numerical simulations. To evaluate the amount of HETP and dry and wet pressure drop, 3D computational fluid dynamic modeling with respect to the Eulerian‐Eulerian multiphase approach was applied. The average relative errors were determined between the findings achieved from computational fluid dynamic simulation and experimental findings for mass transfer efficiency and wet and dry pressure drop, respectively.
Plasma spectroscopy + chemometrics: An ideal approach for the spectrochemical analysis of iron phosphate glass samples
Authors: Devangad Praveen , V K Unnikrishnan , M. Yogesha , Kulkarni Suresh D. , Chidangil Santhosh 
Published: November 2020

AbstractThe penultimate aim of all analytical techniques is to provide best quantitative information with high sensitivity and accuracy. Such techniques then can be ideal to estimate the concentration of different species in a sample or to measure the surface concentration and so on. The preliminary step involved in quantitative analysis is evaluation of the system response for a given amount of the analyte under investigation. Different methodologies are proposed and executed for the above mentioned purpose. In this work, we have demonstrated the performance of chemometric methods to study the atomic emissions from simulated nuclear waste glasses. Five samples of iron‐phosphate glasses were synthesized by doping Cr, Sr, and Ti at various concentrations. The spectra recorded using laser‐induced breakdown spectroscopy (LIBS) system were analyzed using principal component analysis (PCA), partial least square‐discriminant analysis (PLS‐DA), and support vector machines (SVM) for the classification. As compared with the PLS‐DA, SVM provided better results for classification with accuracy of 100% on both calibration and validation sets, respectively. The quantitative analysis of glass samples is carried out using partial least square regression (PLSR) and support vector regression (SVR). The root mean squared error of prediction (RMSEP) is found to be 0.16, 0.20, and 0.08 (wt%) for Cr, Sr, and Ti using PLSR. The detailed investigation elucidates the advantages of chemometrics in handling the complex LIBS spectrum of glass samples and their significance in process control of nuclear waste, nuclear forensics, and so on.
New Luminescent Tetranuclear Lanthanide‐Based Silsesquioxane Cage‐Like Architectures
Authors: Kulakova Alena N. , Bilyachenko Alexey N. , Levitsky Mikhail M. , Khrustalev Victor N. , Shubina Elena S. , Felix Gautier , Mamontova Ekaterina , Long Jérôme , Guari Yannick , Larionova Joulia 
Published: November 2020

AbstractInvited for the cover of this issue are Alexey N. Bilyachenko, Joulia Larionova and co‐workers at the Russian Academy of Sciences, the Peoples’ Friendship University of Russia, and University of Montpellier. The image depicts lanthanide‐based cage‐like silsesquioxanes exhibiting magnetic and luminescence properties that could constitute a particularly interesting new family related to multifunctional nanomaterials. Read the full text of the article at 10.1002/chem.202003351.
Large‐Amplitude Thermal Vibration‐Coupled Valence Tautomeric Transition Observed in a Conductive One‐Dimensional Rhodium–Dioxolene Complex
Authors: Mitsumi Minoru , Komatsu Yuuki , Hashimoto Masahiro , Toriumi Koshiro , Kitagawa Yasutaka , Miyazaki Yuji , Akutsu Hiroki , Akashi Haruo 
Published: November 2020

AbstractThe exploration of dynamic molecular crystals is a fascinating theme for materials scientists owing to their fundamental science and potential application to molecular devices. Herein, a one‐dimensional (1D) rhodium‐dioxolene complex is reported that exhibits drastic changes in properties with the phase transition. X‐ray photoelectron spectroscopy (XPS) revealed that the room‐temperature (RT) phase is in a mixed‐valence state, and therefore, the drastic changes originate from the mixed‐valence state appearing in the RT phase. Another notable feature is that the mean square displacements of the rhodium atoms along the 1D chain dramatically increased in the RT phase, indicating a large‐amplitude vibration of the Rh−Rh bonds. From these results, a possible mechanism for the appearance of the mixed‐valence state in the RT phase was proposed based on the thermal electron transfer from the 1D d‐band to the semiquinonato π* orbital coupled with the large‐amplitude vibration of the Rh−Rh bonds.
Investigation of Luminescent Triplet States in Tetranuclear CuI Complexes: Thermochromism and Structural Characterization
Authors: Boden Pit , Di Martino‐Fumo Patrick , Busch Jasmin M. , Rehak Florian R. , Steiger Sophie , Fuhr Olaf , Nieger Martin , Volz Daniel , Klopper Willem , Bräse Stefan , Gerhards Markus 
Published: November 2020

AbstractTo develop new and flexible CuI containing luminescent substances, we extend our previous investigations on two metal‐centered species to four metal‐centered complexes. These complexes could be a basis for designing new organic light‐emitting diode (OLED) relevant species. Both the synthesis and in‐depth spectroscopic analysis, combined with high‐level theoretical calculations are presented on a series of tetranuclear CuI complexes with a halide containing Cu4X4 core (X=iodide, bromide or chloride) and two 2‐(diphenylphosphino)pyridine bridging ligands with a methyl group in para (4‐Me) or ortho (6‐Me) position of the pyridine ring. The structure of the electronic ground state is characterized by X‐ray diffraction, NMR, and IR spectroscopy with the support of theoretical calculations. In contrast to the para system, the complexes with ortho‐substituted bridging ligands show a remarkable and reversible temperature‐dependent dual phosphorescence. Here, we combine for the first time the luminescence thermochromism with time‐resolved FTIR spectroscopy. Thus, we receive experimental data on the structures of the two triplet states involved in the luminescence thermochromism. The transient IR spectra of the underlying triplet metal/halide‐to‐ligand charge transfer (3M/XLCT) and cluster‐centered (3CC) states were obtained and interpreted by comparison with calculated vibrational spectra. The systematic and significant dependence of the bridging halides was analyzed.
Simultaneous NOx and SO2 removal during wet flue gas desulfurization, using copper smelter slag slurry combined with yellow phorphorus
Authors: Bao Jiacheng , Xiao Helu , Li Kai , Wang Chi , Song Xin , Sun Xin , Ning Ping , Luo Yansu 
Published: November 2020

AbstractThe study of copper slag has attracted the attention of scholars from both China and around the world. But few have paid attention to its applications in the simultaneous removal of SO2 and NOx in wet flue gas desulfurization (WFGD), becasue WFGD technique is inappropriate for directly treating NOx owing to the low solubility of NO. This work aims to improve NOx removal efficiency in WFGD technology using copper slag slurry associated with the oxidation of NOx by yellow phosphorus. Different operating conditions, including dispersion of P4, solid‐liquid ratio, initial pH value of copper slag slurry, reaction temperature, oxygen content, and gas flow rate, were compared regarding the efficiency of SO2 and NOx simultaneous removal. The characterizations were carried out on the liquid and solid part of fresh and spent copper slag slurry after filtration. The results indicated that a great amount of metals ions, such as Fe3+ and Zn2+, were leached by reacting with produced acids (H2SO4, HNO3, and H3PO4), which had a liquid‐phase catalytic oxidation on SIV species (SO32−/HSO3−), leading to promotion in absorption for SO2. The copper slag played a significant role in dispersing the yellow phosphorus and promoting ozone generation, thus improving NOx removal efficiency. The reaction pathway can be divided into three parts: (a) ozone generation induced by yellow phosphorus, (b) the oxidation of NO by O3 and then dissolution in aqueous solution, and (c) the dissolution of SO2 and the liquid‐phase oxidation for SO2 through metal ions produced by the reaction between acid and copper slag.
Fast uncertainty quantification of tracer distribution in the brain interstitial fluid with multilevel and quasi Monte Carlo
Authors: Croci Matteo , Vinje Vegard , Rognes Marie E. 
Published: November 2020

AbstractEfficient uncertainty quantification algorithms are key to understand the propagation of uncertainty—from uncertain input parameters to uncertain output quantities—in high resolution mathematical models of brain physiology. Advanced Monte Carlo methods such as quasi Monte Carlo (QMC) and multilevel Monte Carlo (MLMC) have the potential to dramatically improve upon standard Monte Carlo (MC) methods, but their applicability and performance in biomedical applications is underexplored. In this paper, we design and apply QMC and MLMC methods to quantify uncertainty in a convection‐diffusion model of tracer transport within the brain. We show that QMC outperforms standard MC simulations when the number of random inputs is small. MLMC considerably outperforms both QMC and standard MC methods and should therefore be preferred for brain transport models.
Recommender‐as‐a‐service with chatbot guided domain‐science knowledge discovery in a science gateway
Authors: Vekaria Komal , Calyam Prasad , Sivarathri Sai Swathi , Wang Songjie , Zhang Yuanxun , Pandey Ashish , Chen Cong , Xu Dong , Joshi Trupti , Nair Satish 
Published: November 2020

SummaryScientists in disciplines such as neuroscience and bioinformatics are increasingly relying on science gateways for experimentation on voluminous data, as well as analysis and visualization in multiple perspectives. Though current science gateways provide easy access to computing resources, data sets and tools specific to the disciplines, scientists often use slow and tedious manual efforts to perform knowledge discovery to accomplish their research/education tasks. Recommender systems can provide expert guidance and can help them to navigate and discover relevant publications, tools, data sets, or even automate cloud resource configurations suitable for a given scientific task. To realize the potential of integration of recommenders in science gateways in order to spur research productivity, we present a novel “OnTimeRecommend” recommender system. The OnTimeRecommend comprises of several integrated recommender modules implemented as microservices that can be augmented to a science gateway in the form of a recommender‐as‐a‐service. The guidance for use of the recommender modules in a science gateway is aided by a chatbot plug‐in viz., Vidura Advisor. To validate our OnTimeRecommend, we integrate and show benefits for both novice and expert users in domain‐specific knowledge discovery within two exemplar science gateways, one in neuroscience (CyNeuro) and the other in bioinformatics (KBCommons).
Impact of Ion‐Pairing Effects on Linear and Nonlinear Photophysical Properties of Polymethine Dyes**
Authors: Pascal Simon , Chi San‐Hui , Perry Joseph W. , Andraud Chantal , Maury Olivier 
Published: November 2020

AbstractThe two‐photon absorption (2PA) and photophysics of heptamethine dyes featuring cyanine or dipolar electronic structures have been compared for the first time. The perfectly delocalized cyanine system is classically characterized by a two‐photon transition matching the vibronic component of its lower energy absorption band. The dipolar species is generated by ion‐pairing with a hard counterion in a non‐dissociating solvent and displays significant modifications oft he optical properties, including a significant hypochromic shift of absorption, weaker emission and 2PA matching the lower energy transition, thus revealing symmetry breaking within the polymethine electronic structure.
Culture of Intestinal Epithelial Cell Monolayers and Their Use in Multiplex Macromolecular Permeability Assays for In Vitro Analysis of Tight Junction Size Selectivity
Authors: Pongkorpsakol Pawin , Turner Jerrold R. , Zuo Li 
Published: November 2020

AbstractTight junctions form a selectively permeable barrier that limits paracellular flux across epithelial‐lined surfaces. Small molecules (less than ∼8 Å diameter) can traverse the junction via the size‐ and charge‐selective, high‐conductance pore pathway. In contrast, the low‐conductance leak pathway accommodates larger macromolecules (up to ∼100 Å diameter) and is not charge‐selective. Flux across the tight junction–independent, high‐conductance, non‐selective, unrestricted pathway occurs at sites of epithelial damage. Cytokines can regulate each of these pathways, but commonly used measures of barrier function cannot discriminate between tight junction regulation and epithelial damage. This article describes methods for culturing intestinal epithelial cell monolayers and assessing the impact of cytokine treatment on leak and unrestricted pathway permeabilities. © 2020 Wiley Periodicals LLC.Basic Protocol 1: Generation and culture of cell monolayers in TranswellsBasic Protocol 2: Assessment of cytokine (IFNγ and TNF) treatment effects on barrier functionSupport Protocol: Immunofluorescent staining of monolayersBasic Protocol 3: Multiplex flux assay
Dissecting the Biology of the Fungal Wheat Pathogen Zymoseptoria tritici: A Laboratory Workflow
Authors: Fagundes Wagner C. , Haueisen Janine , Stukenbrock Eva H. 
Published: November 2020

AbstractThe fungus Zymoseptoria tritici is one of the most devastating pathogens of wheat. Aside from its importance as a disease‐causing agent, this species has emerged as a powerful model system for evolutionary genetic studies of crop‐infecting fungal pathogens. Z. tritici exhibits exceptionally high levels of genetic and phenotypic diversity as well as morphological plasticity, which can make experimental studies and comparability of results obtained in different laboratories, e.g., from infection assays, challenging. Therefore, standardized experimental methods are crucial for research on Z. tritici biology and the interaction of this fungus with its wheat host. Here, we describe a suite of well‐tested and optimized protocols ranging from isolation of Z. tritici field specimens to analyses of virulence assays under controlled conditions. Several biological and technical aspects of working with Z. tritici under laboratory conditions are considered and carefully described in each protocol. © 2020 The Authors.Basic Protocol 1: Purification of Z. tritici field isolates from leaf materialBasic Protocol 2: Molecular identification of Z. tritici isolatesSupport Protocol 1: Rapid extraction of Z. tritici genomic DNASupport Protocol 2: Extraction of high‐quality Z. tritici genomic DNABasic Protocol 3: In vitro culture and long‐term storage of Z. tritici isolatesBasic Protocol 4: Analysis of Z. tritici virulence in wheatSupport Protocol 3: Preparation of Z. tritici inoculum
Depolymerization of Technical‐Grade Polyamide 66 and Polyurethane Materials through Hydrogenation
Authors: Zhou Wei , Neumann Paul , Al Batal Mona , Rominger Frank , Hashmi A. Stephen K. , Schaub Thomas 
Published: November 2020

AbstractChemical recycling provides a promising solution to utilize plastic waste. Here, a catalytic hydrogenative depolymerization of polyamide 66 (PA 66) and polyurethane (PU) was developed. The system employed Ru pincer complexes at high temperature (200 °C) in THF solution, and even technical‐grade polymers could be hydrogenated with satisfactory yields under these conditions. A comparison of the system with some known heterogeneous catalysts as well as catalyst poisoning tests supported the homogeneity of the system. These results demonstrate the potential of chemical recycling to regain building blocks for polymers and will be interesting for the further development of polymer hydrogenation.
Natural history of model organisms: The secret (group) life of Drosophila melanogaster larvae and why it matters to developmental ecology
Authors: Morimoto Juliano , Pietras Zuzanna 
Published: November 2020

Abstract

Model organisms such as Drosophila melanogaster have been key tools for advancing our fundamental and applied knowledge in biological and biomedical sciences. However, model organisms have become intertwined with the idea of controlled and stable laboratory environments, and their natural history has been overlooked.

In holometabolous insects, lack of natural history information on larval ecology has precluded major advances in the field of developmental ecology, especially in terms of manipulations of population density early in life (i.e., larval density). This is because of relativistic and to some extent, arbitrary methodologies employed to manipulate larval densities in laboratory studies. As a result, these methodologies render comparisons between species impossible, precluding our understanding of macroevolutionary responses to population densities during development that can be derived from comparative studies.

We recently proposed a new conceptual framework to address this issue, and here, we provide the first natural history investigation of Drosophila melanogaster larval density under such framework. First, we characterized the distribution of larval densities in a wild population of D. melanogaster using rotting apples as breeding substrate in a suburban area in Sweden.

Next, we compiled the commonly used methodologies for manipulating larval densities in laboratory studies from the literature and found that the majority of laboratory studies identified did not manipulate larval densities below or above the densities observed in nature, suggesting that we have yet to study true life history and physiological responses to low and high population densities during D. melanogaster development.

This is, to our knowledge, the first direct natural history account of larval density in nature for this model organism. Our study paves the way for a more integrated view of organismal biology which re‐incorporates natural history of model organisms into hypothesis‐driven research in developmental ecology.