bluuebunny/crossref_metadata_2025_split huggingface dataset:
Common Site of Urinary Calculi in Kidney, Ureter and Urinary Bladder Region: Jos Experience
Authors: Danjem Samuel Moses , AJ Salaam , Yunusa HO Kolade- , SI Shuaibu 
Published: October 2019

Objective: To determine the common location of calculus along the urinary tract using CT scan.
Methods: This cross sectional study was conducted using CT from November 2016 to September 2018, in a tertiary hospital in Jos, Nigeria. The CT images acquired from this period were evaluated and 50 patients were positive for urolithiasis. The data was subjected to statistical analysis based on age, gender and calculus location.
Results: Out of the 50 patients with calculi, 34 were males and 16 were females with a male to female ratio of 2.13:1. 137 urinary calculi were documented in which 90 were in males and 47 in the female patients. Highest occurrence of calculi was seen in age group 31-40 years (34.0%). 112(82%) were renal stones, 12(9%) were ureteric stones, 8(6%) were found in pelvi-ureteric junction (PUJ), 3(2%) were in the vesico-ureteric junction (VUJ), 2(1%) were in the urinary bladder and none in the urethra.
Conclusion: Kidney stones are the most common followed by the ureter, the pelvi-ureteric junction, the vesico-ureteric junction and the bladder.
Analisis Faktor Persepsi Nasabah Bank Konvensional dan Switching Barriers Ke Bank Syariah
Authors: Slamet Slamet , Munir Misbahul , Hasan Irmayanti 
Published: October 2019

This research is to identify and analyze the factors of conventional bank customers' perception in Pondok Pesantren community in using Islamic banking services and identify and analyze switching barriers factors to become sharia bank customers for the Pondok Pesantren community. The paradigm in this research uses quantitative research with a CFA approach. The results showed that the factors that become conventional bank customers' perceptions in using Islamic banking for the Islamic boarding school community are comprised of three perceptions, namely customer perception variables consisting of a cognitive dimension, affective, and connectively. This means that respondents already have a dominant perception of the Islamic banking system. This is indicated by that they have an understanding and knowledge of the existence and sharia banking system in Indonesia, although some of them use conventional banking services. There are several factors causing switching barriers to become customers of Islamic banks in the Pondok Pesantren community, from the loading factor value it is known that the dimension of value congruency is the dominant dimension in forming switching barriers variables in conventional banks.
ANADOLU SAHASINA AİT TÜRKÇE İLK KUR’AN TERCÜMELERİ ÜZERİNE BİR BİBLİYOGRAFYA DENEMESİ
Authors: YILDIRIM İbrahim Kemal 
Published: October 2019

Türklerin İslâmiyet’i kabulüyle birlikte İslâmi eserler de
Türk dili sahasındaki yerini almaya başlamıştır. Bu eserler sırasıyla; Kutadgu Bilig, Divân-ı Lügati’t Türk,
Atabetü’l Hakayık, Divân-ı Hikmet’tir. Bunun yanı sıra Tefsirler, Sûre
tefsirleri ve Satırarası tercümelerden oluşan Kur’an tercümeleri de bu
eserlerdendir. Dinî içerikli, didaktik olması ve dönemin özelliklerini yansıtması
açısından bu eserler oldukça önem taşımaktadır. Satırarası kelime kelime
tercüme olan Kur’an tercümeleri söz varlığı açısından da oldukça önemlidir. İlk
örnekleri Karahanlı-Harezm Türkçesi ile yapılan bu tercümelere XIV. yüzyıldan itibaren
Anadolu sahasında Eski Anadolu Türkçesi ile yapılan tercümeler de eklenmiştir.
Doğu sahasında yapılan Kur’an tercümeleri ile kıyasladığımızda Anadolu
sahasında yapılan tercümeler sayıca fazladır. Bu eserlerin birçoğunun müellifi
ve müstensihi bilinirken birçoğununki de bilinmemektedir. Tercümeler üzerine
birçok akademik çalışma bulunmasına rağmen hâla üzerine çalışma yapılmamış
olanlar da mevcuttur. Bu makalede Anadolu sahasına ait ilk Türkçe Kur’an
tercümeleri üzerine yurt içi ve yurt dışında yapılan çalışmalar ana hatlarıyla değerlendirilecek ve
bir bibliyografya denemesi yapılacaktır.
Avaliação do crescimento inicial das mudas de Tabebuia serratifolia (Ipê Amarelo) sob diferentes regimes hídricos.
Authors: Silva Marcos Cardoso , Maciel Danilo , Coelho Maria Cristina Bueno , Giongo Marcos , Pereira José Fernando , Dos Santos André Ferreira 
Published: October 2019

Este trabalho teve como objetivo avaliar o crescimento inicial das mudas de Tabebuia serratifolia (ipê amarelo) sob diferentes regimes hídricos, de forma a encontrar o que melhor se adapta para a espécie em fase inicial de crescimento. Foram utilizados os seguintes equipamentos para a mensuração das variáveis dendrométricas sendo elas: paquímetro digital para medir DAC (Diâmetro Altura do Colo) e régua milimétrica para medir a altura das mudas. O delineamento utilizado foi DIC (Delineamento Inteiramente Casualizado) onde realizou-se 6 repetições com 5 tratamento num total de 30 indivíduos, submetidas a diversos estresse hídrico, e uma testemunha. Concluiu-se que as sementes de Ipê Amarelo apresentam capacidade de adaptação ao estresse hídrico moderado, apresentando potencial para ser utilizada com sucesso em algumas fases da recuperação de áreas degradadas; contudo, o déficit hídrico severo pode afetar o início da germinação e atrasar seu desenvolvimento.
Management of Non-Muscle-invasive Bladder Cancer: Quality of Clinical Practice Guidelines and Variations in Recommendations
Authors: Zhang Jing , Wang Yunyun , Weng Hong , Wang Danqi , Han Fei , Huang Qiao , Deng Tong , Wang xinghuan , Jin Yinghui 
Published: October 2019

Abstract
Background: Bladder cancer (BC) has become a major worldwide public health issue, especially non-muscle-invasive bladder cancer (NMIBC). A flood of related clinical practice guidelines (CPGs) have emerged; however, the quality and recommendations of the guidelines are controversial. We aimed to appraise the quality of the CPGs for NMIBC within the past 5 years and compare the similarities and differences between recommendations for therapies.
Methods: A systematic search to identify CPGs for NMIBC was performed using electronic databases (including PubMed, Embase, Web of Science), guideline development organizations, and professional societies from January 12, 2014 to January 12, 2019. The Appraisal of Guidelines Research & Evaluation (AGREE) II instrument was used to evaluate the quality of the guidelines. Intraclass correlation coefficient (ICC) analysis was performed to assess the overall agreement among reviewers.
Results: Nine CPGs were included. The overall agreement among reviewers was excellent. The interquartile range (IQR) of scores for each domain were as follows: scope and purpose 69.44% (35.42%, 85.42%); stakeholder involvement 41.67% (30.56%, 75.00%); rigour of development 48.96% (27.08%, 65.63%); clarity and presentation 80.56% (75.00%, 86.11%); applicability 34.38% (22.92%, 40.63%) and editorial independence 70.83% (35.42%, 85.42%). The NICE, AUA, EAU and CRHA/CPAM clinical practice guidelines consistently scored well in most domains.
It was generally accepted that the transurethral resection of bladder tumour (TURBT) and intravesical chemotherapy should be performed in the management of bladder cancer. The application of chemotherapy was highly controversial in high risk NMIBC. The courses of BCG maintenance were similar and included 3 years of therapy at full maintenance doses.
Conclusions: The quality of NMIBC guidelines within the past 5 years varied, especially regarding stakeholders, rigour and applicability. Despite many similarities, the recommendations had some inconsistencies in the details.
Regulation of the mTERT telomerase catalytic subunit by the c-Abl tyrosine kinase in mouse granulosa cells
Authors: Yaba Aylin , Agus Sami , Yildirim Ecem , Erdogan Cihan S. , Yilmaz Bayram 
Published: October 2019

Abstract
Background: Oocyte and granulosa cells (GCs) have bidirectional communication and GCs play an important role in folliculogenesis and proliferation of GCs is very important for the development of ovulatory follicle. DNA double-strand breaks activate c-Abl protein tyrosine kinase and c-Abl has a functional role in repairment of DNA and control of telomere. In this study, we hypothesized that c-Abl has a regulative role on mTERT in mouse ovarian granulosa cells (GCs) and we aimed to detect c-Abl and mTERT interaction in mouse primary culture of GCs.
Results: We showed c-Abl and mTERT immunolocalization in vivo and in vitro mouse GCs. c-Abl and mTERT were constitutively expressed in mouse granulosa cells and c-Abl presented more intense expression in granulosa cells than mTERT expression. The interaction of the c-Abl-mTERT is supported by the exhibition that c-Abl siRNA knockdown cells show decreased mTERT expression. We also present an interaction between c-Abl and mTERT by immunoprecipitation. In addition, our results indicated that the down-regulation of c-Abl was also accompanied by reduced expression of proliferating cell nuclear antigen (PCNA) in GCs.
Conclusions: We suggest that mTERT may associate with the c-Abl in mouse GCs and the interactions between c-Abl and mTERT suggest a role for c-Abl in the regulation of telomerase function and proliferation in mouse granulosa cells during folliculogenesis.
Staff expectations for the implementation of an electronic health record system: A qualitative study using Normalisation Process Theory
Authors: Mccrorie Carolyn , Benn Jonathan , Johnson Owen , Scantlebury Arabella 
Published: October 2019

Abstract
Background
Global evidence suggests a range of benefits for introducing electronic health record (EHR) systems to improve patient care. However, implementing EHR within healthcare organisations is complex and in the United Kingdom (UK), uptake has been slow. More research is needed to explore factors influencing successful implementation. This study explored staff expectations for change and outcome following procurement of a commercial EHR system by a large academic acute NHS hospital in the UK.
Methods
Qualitative interviews were conducted with 14 members of hospital staff who represented a variety of user groups across different specialities within the hospital. The four components of Normalisation Process Theory (Coherence, Cognitive participation, Collective action and Reflexive monitoring) provided a theoretical framework to interpret and report study findings.
Results
Health professionals had a common understanding for the rationale for EHR implementation (Coherence). There was variation in willingness to engage with and invest time into EHR (Cognitive participation) at an individual, professional and organisational level. Collective action (whether staff feel able to use the EHR) was influenced by context and perceived user-involvement in EHR design and planning of the implementation strategy. When appraising EHR (Reflexive monitoring), staff anticipated short and long-term benefits. Staff perceived that quality and safety of patient care would be improved with EHR implementation, but that these benefits may not be immediate. Some staff perceived that use of the system may negatively impact patient care. The findings indicate that preparedness for EHR use could mitigate perceived threats to the quality and safety of care.
Conclusions
Health professionals looked forward to reaping the benefits from EHR use. Variations in level of engagement suggest early components of the implementation strategy were effective, and that more work was needed to involve users in preparing them for use. A clearer understanding as to how staff groups and services differentially interact with the EHR as they go about their daily work was required. The findings may inform other hospitals and healthcare systems on actions that can be taken prior to EHR implementation to reduce concerns for quality and safety of patient care and improve the chance of successful implementation.
A novel electrochemical aptasensor for fumonisin B1 determination using DNA and exonuclease-I as signal amplification strategy
Authors: Wei Min , Zhao Fei , Feng Shuo , Jin Huali 
Published: October 2019

Abstract
In this work, using DNA and exonuclease-I (Exo-I) as signal amplification strategy, a novel and facile electrochemical aptasensor was constructed for fumonisin B1 (FB1) detection. The G-rich complementary DNA (cDNA) was immobilized onto the electrode surface. Then, aptamer of FB1 was hybridized with cDNA to form double-stranded DNA. In the absence of FB1, double-stranded DNA and G-rich cDNA on the electrode surface promoted effectively methylene blue (MB) enrichment and amplified the initial electrochemical response. In the presence of FB1, the combination of aptamer and FB1 led to the release of aptamer from the electrode surface and the expose of 3' end of single-stranded cDNA. When Exo-I was added onto the electrode surface, the single-stranded cDNA was degraded in the 3’-5’ direction. The decrease of double-stranded DNA and G-rich cDNA resulted in the less access of MB to the electrode surface, which decreased the electrochemical signal. The experimental conditions including incubation time of FB1, the amount of Exo-I and incubation time of Exo-I were optimized. Under the optimal conditions, the linear relationship between the change of peak current and the logarithmic concentration of FB1 was observed in the range of 1.0×10-3-1000ng·mL−1 with a low limit of detection of 0.15 pg·mL−1. The experimental results showed that the prepared aptasensor had acceptable specificity, reproducibility, repeatability and stability. Therefore, this proposed aptasensor has a potential application in the food safety detection.
Magnetic Resonance Enterography, Colonoscopy, and Fecal Calprotectin correlate in colonic Crohn’s Disease
Authors: Somwaru Alexander S. , Khanijow Vikesh , Katabathina Venkat S. 
Published: October 2019

Abstract
ABSTRACT
Background: Fecal calprotectin (FCP), magnetic resonance enterography (MRE), and colonoscopy are complementary biometric tests that are used to assess patients with Crohn’s Disease (CD). While prior studies have evaluated the association between combinations of these tests, no study has established a correlation between all three: FCP, MRE, and colonoscopy. We prospectively investigated if there is correlation between these three tests, which may result in improved clinical outcomes that can then be used to streamline patient monitoring and treatment modification.
Methods: 156 patients with colonic CD were prospectively examined between March 2017 and December 2018. FCP levels, MRE, and colonoscopy were assessed in parallel on all 156 patients. Clinical CD activity was measured with the Crohn’s Disease Activity Index (CDAI). CD activity with FCP was measured with a quantitative immunoassay. CD activity on MRE was measured with the Magnetic Resonance Index of Activity (MaRIA). CD activity on colonoscopy was measured with the Crohn’s Disease Endoscopic Index of Severity (CDEIS).
Results: 112 patients (72%) had active disease (Crohn’s Disease Activity Index > 150) and 44 patients (28%) were in clinical remission disease (Crohn’s Disease Activity Index < 150). FCP levels, MaRIA, and CDEIS are highly correlated with positive and significant Pearson and Spearman coefficients, respectively (P < 0.0001), in univariate analyses. Regression analysis (multivariate analyses) demonstrates significant, positive correlation between FCP and MaRIA (r = 1.07, P < 0.0001) and between FCP and CDEIS (r = 0.71, P = 0.03), and between
MaRIA and CDEIS (r = 0.63, P = 0.01).
Conclusions: FCP levels significantly correlate with the degree of active inflammation in patients with colonic Crohn’s Disease. Improved clinical results may be achieved by using a biometric strategy that incorporates FCP, colonoscopy, and MRE together. This strategy may in-turn be used in the future to streamline monitoring disease activity and adjustment of therapy to improve long term patient outcomes.
Effect of Calcium on the Interaction of Acinetobacter baumannii with Human Respiratory Epithelial Cells
Authors: Chen Yi , Shao Tingjun , Fang Sanhua , Pan Ping , Jiang Jiahui , Cheng Tongtong , Wan Haitong , Yu Daojun 
Published: October 2019

Abstract
Background: Investigating the factors that influence Acinetobacter baumannii (Ab) adhesion/invasion of host cells is important to understand its pathogenicity. Metal cations have been shown to play an important role in regulating the biofilm formation and increasing the virulence of Ab; however, the effect of calcium on host-bacterial interaction has yet to be clarified. Here, the dynamic process of the interaction between Ab and human respiratory epithelial cells and the effect of calcium on host-bacterial interaction were explored using the technologies of microscopic imaging, quantitative PCR and real time cellular analysis (RTCA).
Results: The concentration of calcium, multiplicity of infection and co-culture time were demonstrated to have effects on host-bacterial interaction. A unique "double peak" phenomenon changed to a sharp "single peak" phenomenon during the process of Ab infection under the effect of calcium were determined based on the time-dependent cell response profiles. Moreover, calcium can increase Ab adhesion/invasion of epithelial cells by regulating the expression of Ab-related genes ( ompA , bfmRS , abaI ).
Conclusions: Effective control of calcium concentrations can provide new ideas for the prevention and treatment of multi-drug resistant Ab.
Effects of low glycemic index/high-fat, high-calorie diet compared to the high-fat, high-calorie diet on glycemic control, lipid profile, and inflammatory markers in children and adolescence with cystic fibrosis: A study protocol for a randomized double-blind controlled clinical trial
Authors: Gorji Zahra , Modaresi Mohammadreza , Yekanni-Nejad Saeed , Mahmoudi Maryam 
Published: October 2019

Abstract
Background: Inflammation plays an important role in pathogenesis of cystic fibrosis, and diet is considered as an effective factor in controlling inflammation. Low glycemic index diet seems to be effective for improving glycemic control and reducing the inflammation and lipid profile. Hence, this study was planned to compare the effects of a low glycemic index/high fat, high calorie diet with the high fat, high calorie diet on glycemic status, lipid profile, and inflammatory markers in patients with cystic fibrosis. Methods: A total of 60 children and adolescence with cystic fibrosis will be randomized to receive a high fat, high calorie diet (n=30) or low glycemic index/high fat, high calorie diet (n=30) with similar calorie and macronutrients composition, for three months. Patients in high fat, high calorie diet arm will be able to use all sources of carbohydrates with different glycaemic indices; while those in another arm will be received their carbohydrate from low glycemic index sources. Before and after the intervention, serum levels of lipid profile (triglyceride, total cholesterol, HDL cholesterol, LDL cholesterol), insulin, glucose, HbA1c, the homeostasis model assessment-estimated insulin resistance index, and some inflammatory markers (IL-6, IL-10, IL-17A, and IFNγ) will be measured. Discussion: To our knowledge, this study will be the first to examine the effects of a low glycemic index/high fat, high calorie diet compared to the high fat, high calorie diet in cystic fibrosis patients. The findings of this study might provide evidence to improve the nutritional status and immune system as well as to prevent the disease complications in these patients.
Efficacy of high dose versus low dose vitamin D supplementation on serum levels of inflammatory factors and mortality rate in severe traumatic brain injury patients: study protocol for a randomized placebo-controlled trial
Authors: Arabi Seyed Mostafa , Sedaghat Alireza , Ehsaei Mohammadreza , Safarian Mohammad , Ranjbar Golnaz , Rezaee Hamid , Rezvani Reza , Tabesh Hamed , Norouzy Abdolreza 
Published: October 2019

Abstract
Background Traumatic Brain Injury (TBI) is the most common trauma worldwide and is a leading cause of injury-related death and disability. Inflammation is a major problem among TBL patients which is in association with severity of illness and mortality in brain trauma patients, especially in subdural hemorrhage and epidural hemorrhage cases. A high percentage of adults admitted to the intensive care unit with critical conditions are diagnosed with vitamin D-deficiency, this deficiency may induce impaired immune responses and increase the risk of infections. Vitamin D intervention has been shown to modulate pro- and anti-inflammatory cytokines in non-critically ill patients, but to date, there is no substantial data on the effectiveness of vitamin D for the improvement of immune function in traumatic brain injury patients.Methods/design A randomized clinical trial (RCT) will be performed on 74 Iranian adults 18-65 years old with brain trauma, and will be treated daily by vitamin D supplements (100000 IU oral drop) or a similar placebo (1000 IU) for 5 days.Discussion If this randomized clinical trial elucidates reduction in inflammatory cytokines, it would provide the evidence for multi-central clinical trials to evaluate the efficacy of vitamin D supplementation in neuro -critically ill patients. Since vitamin D supplements are inexpensive and safe, this clinical trial could have the potential to improve clinical outcomes in traumatic brain injury patients through reduction of inflammation and infection associated morbidity and mortality rates.
Development and validation of a risk-prediction nomogram for chronic low back pain using a national health examination survey
Authors: Park Jiwon , Kim Jung-Taek , Park Sang-Min , Kwon Ohsang , Kim Hyoungmin , Kim Ho-Joong , Yeom Jin S. , Chang Bong-Soon 
Published: October 2019

Abstract
Background Several prognostic factors for chronic low back pain (CLBP) have been reported. However, there is no study regarding the prediction of CLBP development in general population, using a risk prediction model. Based on this background, the aims of this study were: (1) to develop and validate a risk prediction model for CLBP (chronic low back pain) development in the general population, and (2) to create a nomogram which can help a person at risk of developing CLBP to receive appropriate counseling on risk modification.Methods Data on CLBP development, demographics, socioeconomic history, and comorbid health condition of participants were obtained through a nationally representative health examination and survey from 2007 to 2009. Prediction models for CLBP development were derived for health survey on a random sample of 80% of the data and were validated in the remaining 20%. After developing the risk prediction model for CLBP development, this model was incorporated into a nomogram.Results Data for 17,038 participants were finally analyzed, including 2,693 with CLBP and 14,345 without. The finally selected risk factors included age, gender, occupation, education level, mid-intensity physical activity, depressive symptom, and comorbidities. This model had good predictive performance in the validation dataset (concordance statistic = 0.7569, Hosmer-Lemeshow chi-square statistic = 12.10, p =.278). The findings indicated no significant differences between the observed probability and predicted probability according to our model.Conclusions The risk prediction model, presented by a nomogram, which is a score-based prediction system, could be incorporated into the clinical setting. Thus, our prediction model with a nomogram can help a person at risk of developing CLBP to receive appropriate counseling on risk modification from primary physicians.