bluuebunny/crossref_metadata_2025_split huggingface dataset:
Montreal Cognitive Assessment (MoCA) Performance and Domain-Specific Index Scores in Amnestic Versus Aphasic Dementia
Authors: Wood Jessica L. , Weintraub Sandra , Coventry Christina , Xu Jiahui , Zhang Hui , Rogalski Emily , Mesulam Marek-Marsel , Gefen Tamar 
Published: May 2020

ABSTRACTObjective:The Montreal Cognitive Assessment (MoCA) is a popular and simple-to-administer screening instrument to detect cognitive impairment. The MoCA generates a total score and six domain-specific index scores: (1) Memory, (2) Executive Functioning, (3) Attention, (4) Language, (5) Visuospatial, and (6) Orientation. It is unclear whether these MoCA scores can differentiate between distinct clinical dementia syndromes. This study compared MoCA Index scores between amnestic dementia of the Alzheimer’s type (DAT) and primary progressive aphasia (PPA), a language-based dementia.Method:Baseline MoCA data were analyzed from 33 DAT, 37 PPA, and 83 cognitively normal individuals enrolled in the Clinical Core of the Northwestern Alzheimer’s Disease Center. A one-way analysis of covariance adjusted for age was used to compare MoCA scores among groups. A logistic regression model was implemented to observe individual likelihood of group affiliation based on MoCA Index scores.Results:The mean MoCA total score was significantly higher in controls compared to both patient groups (p < .001) but did not differ between DAT and PPA groups. However, in accordance with salient clinical features commonly observed in DAT versus PPA, Memory and Orientation Index scores were lowest in the DAT group (p < .001), whereas Language and Attention Index scores were lowest in the PPA group (p < .001). Multivariate logistic regression analysis showed that the individual effects of Memory (p = .001), Language (p = .002), and Orientation (p = .025) Indices were significant.Conclusions:MoCA Index scores can help differentiate among distinct cognitive syndromes, suggesting it may be a useful brief screening tool to detect domain-specific cognitive impairment.
Feather-shaped super wideband MIMO antenna
Authors: Singhal Sarthak 
Published: May 2020

AbstractTwo configurations of a modified feather-shaped antenna element are proposed for super wideband (SWB) multiple-input multiple-output (MIMO) applications. The antenna element geometry comprises of a circular slot-loaded feather-shaped radiator and rectangular notch-loaded quarter elliptical coplanar waveguide ground plane. An operating bandwidth of 4.4–51.5 GHz with inter-port isolation, S21 ≥ 15 dB for spatial diversity configuration, and 3.8–51.5 GHz with S21 ≥ 15 dB in pattern diversity configuration are achieved. The footprints of the antenna configurations are 17 × 33 and 31 × 31 mm2. Both configurations exhibited an envelope correlation coefficient of <−20 dB. The proposed MIMO configurations are fabricated and experimentally validated. The designed antenna configurations are SWB and compact.
Musings on Visscher et al. (2006)
Authors: Visscher Peter M. 
Published: May 2020

AbstractThe classical twin design relies on a number of strong number of assumptions in order to yield unbiased estimates of heritability. This includes the equal environments assumption — that monozygotic and dizygotic twins experience similar degrees of environmental similarity — an assumption that is likely to be violated in practice for many traits of interest. An alternative method of estimating heritability that does not suffer from many of these limitations is to model trait similarity between sibling pairs as a function of their empirical genome-wide identity by descent sharing, estimated from genetic markers. In this review, I recount the story behind Nick Martin’s and my development of this method, our first attempts at applying it in a human population and more recent studies using the original and related methods to estimate trait heritability.
Evolution of High‐Speed Jets and Plasmoids Downstream of the Quasi‐Perpendicular Bow Shock
Authors: Goncharov O. , Gunell H. , Hamrin M. , Chong S. 
Published: May 2020

AbstractPlasma structures with enhanced dynamic pressure, density, or speed are often observed in Earth's magnetosheath. We present a statistical study of these structures, known as jets and fast plasmoids, in the magnetosheath, downstream of both the quasi‐perpendicular and quasi‐parallel bow shocks. Using measurements from the four Magnetospheric Multiscale (MMS) spacecraft and OMNI solar wind data from 2015–2017, we present observations of jets during different upstream conditions and in the wide range of distances from the bow shock. Jets observed downstream of the quasi‐parallel bow shock are seen to propagate deeper and faster into the magnetosheath and on toward the magnetopause. We estimate the shape of the structures by treating the leading edge as a shock surface, and the result is that the jets are elongated in the direction of propagation but also that they expand more quickly in the perpendicular direction as they propagate through the magnetosheath.
First Observations of Magnetosonic Waves With Nonlinear Harmonics
Authors: Huang S. Y. , Deng D. , Yuan Z. G. , Jiang K. , Li J. X. , Deng X. H. , Yu X. D. , He L. H. , Wei Y. Y. , Xu S. B. 
Published: May 2020

AbstractMagnetosonic waves, with the frequency between proton cyclotron frequency and lower hybrid frequency, mainly occur near the Earth's magnetic equatorial plane and play an important role in the magnetospheric dynamics. In this paper, we report unusual magnetosonic waves with nonlinear harmonics observed by Magnetospheric Multiscale mission in the magnetotail. These magnetosonic waves have multiband enhanced electromagnetic power spectral densities (Bw/B0 up to 1/45) with the frequency from below to above the lower hybrid frequency and are quasi‐perpendicular propagating and linearly polarized. The frequency of the fundamental band is much higher than the proton cyclotron frequency fci (i.e., ~35 fci). We identified these emissions as high‐frequency magnetosonic waves with nonlinear harmonics. These are the first observations of such high‐frequency magnetosonic waves with the frequencies of harmonics higher than the lower hybrid frequency in the Earth's magnetosphere to the best of our knowledge. Given the absence of ring distributions for the protons and the easy coupling between compressed mode and its electromagnetic term, we propose that these nonlinear harmonic structures of the observed magnetosonic waves are likely generated by the nonlinear wave‐wave coupling among electromagnetic terms of the fundamental and higher harmonic waves.
A Hybrid Model for Fast and Probabilistic Urban Pluvial Flood Prediction
Authors: Li Xiaohan , Willems Patrick 
Published: May 2020

AbstractUrban flooding is highly uncertain, so the use of probabilistic approaches in early flood warning is encouraged. While well‐established 1‐D/2‐D hydrodynamic sewer models do exist, their deterministic nature and long computational time undermine their applicability for real‐time urban flood nowcasting. Aiming at meeting the needs of fast and probabilistic flood modeling, a new hybrid modeling method integrating a suite of lumped hydrological models and logistic regression is proposed. The lumped models are configured using graph theory techniques, based on the sewer system's topology and characteristics, to account for the spatial heterogeneity and physical processes and properties. The logistic regression models are calibrated to lumped models' results and Yes/No flooding information. Due to its conceptual and data‐driven nature, the hybrid model makes fast probabilistic flood predictions at manhole locations. In two case studies, the results showed that when incorporating most dominant physical processes and properties in the model setup, the hybrid model can achieve up to 86% accuracy for flood warnings issued at 50% probability, with 96% computation saving, compared with a traditional 1‐D hydrodynamic model. When such a detailed model is in place, the hybrid model is set up easily, but the accuracy could be further increased when historical flooding observations are considered.
Reactivation of an Intraplate Fault by Mine‐Blasting Events: Implications to Regional Seismic Hazard in Western Canada
Authors: Dokht Ramin M. H. , Smith Brindley , Kao Honn , Visser Ryan , Hutchinson Jesse 
Published: May 2020

AbstractMining activities are well known for being able to induce local seismicity but have not yet been shown to cause earthquakes over large distances. We analyze a particular group of seismic events recorded from 2014 to 2016 in north‐central British Columbia (BC) that appear to be triggered by the activities at the Mount Milligan Mine. The spatial distribution of the studied events follows a NW‐SE linear trend, with distances up to approximately 100 km from the mining site. To distinguish mining blasts from blasting‐related and natural events, we adopt a multivariate decision tree based on each event's origin time, distance from the mine, and the pseudo‐spectral acceleration ratios of the three‐component waveforms. The calculated dynamic strains from blasts place a distance limit of 20 km for dynamic triggering. However, accounting for the estimated epicentral uncertainty and temporal distribution of the earthquakes' origin times support the existence of blasting‐triggered events at larger distances (up to ∼50 km) from the mine, suggesting that a previously unmapped fault segment is close to critical state and may have been reactivated. The inferred fault segment aligns remarkably well with the southern extent of the Rocky Mountain Trench and may impose a significant hazard to nearby communities if the entire fault segment of about 150 km‐long ruptures.
Improved metabolomic data-based prediction of depressive symptoms using nonlinear machine learning with feature selection
Authors: Takahashi Yuta , Ueki Masao , Yamada Makoto , Tamiya Gen , Motoike Ikuko N. , Saigusa Daisuke , Sakurai Miyuki , Nagami Fuji , Ogishima Soichi , Koshiba Seizo , Kinoshita Kengo , Yamamoto Masayuki , Tomita Hiroaki 
Published: May 2020

AbstractTo solve major limitations in algorithms for the metabolite-based prediction of psychiatric phenotypes, a novel prediction model for depressive symptoms based on nonlinear feature selection machine learning, the Hilbert–Schmidt independence criterion least absolute shrinkage and selection operator (HSIC Lasso) algorithm, was developed and applied to a metabolomic dataset with the largest sample size to date. In total, 897 population-based subjects were recruited from the communities affected by the Great East Japan Earthquake; 306 metabolite features (37 metabolites identified by nuclear magnetic resonance measurements and 269 characterized metabolites based on the intensities from mass spectrometry) were utilized to build prediction models for depressive symptoms as evaluated by the Center for Epidemiologic Studies-Depression Scale (CES-D). The nested fivefold cross-validation was used for developing and evaluating the prediction models. The HSIC Lasso-based prediction model showed better predictive power than the other prediction models, including Lasso, support vector machine, partial least squares, random forest, and neural network.l-leucine, 3-hydroxyisobutyrate, and gamma-linolenyl carnitine frequently contributed to the prediction. We have demonstrated that the HSIC Lasso-based prediction model integrating nonlinear feature selection showed improved predictive power for depressive symptoms based on metabolome data as well as on risk metabolites based on nonlinear statistics in the Japanese population. Further studies should use HSIC Lasso-based prediction models with different ethnicities to investigate the generality of each risk metabolite for predicting depressive symptoms.
Neoadjuvant modified FOLFIRINOX followed by postoperative gemcitabine in borderline resectable pancreatic adenocarcinoma: a Phase 2 study for clinical and biomarker analysis
Authors: Yoo Changhoon , Lee Sang Soo , Song Ki Byung , Jeong Jae Ho , Hyung Jaewon , Park Do Hyun , Song Tae Jun , Seo Dong Wan , Lee Sung Koo , Kim Myung-Hwan , Lee Seung Soo , Kim Jin Hee , Jin Hyung-seung , Park Jin-hong , Hwang Dae Wook , Lee Jae Hoon , Lee Woohyung , Chang Heung-Moon , Kim Kyu-pyo , Ryoo Baek-Yeol , Kim Song Cheol 
Published: May 2020

Abstract
Background
Patients with borderline resectable pancreatic cancer (BRPC) have poor prognosis with upfront surgery.

Methods
This was a single-arm Phase 2 trial for clinical and biomarker analysis. The primary endpoint is 1-year progression-free survival (PFS) rate. Patients received 8 cycles of neoadjuvant modified (m) FOLFIRINOX. Up to 6 cycles of gemcitabine were given for patients who underwent surgery. Plasma immune cell subsets were measured for analysing correlations with overall survival (OS).

Results
Between May 2016 and March 2018, 44 chemotherapy- and radiotherapy-naïve patients with BRPC were included. With neoadjuvant mFOLFIRINOX, the objective response rate was 34.1%, and curative-intent surgery was done in 27 (61.4%) patients. With a median follow-up duration of 20.6 months (95% confidence interval [CI], 19.7–21.6 months), the median PFS and OS were 12.2 months (95% CI, 8.9–15.5 months) and 24.7 months (95% CI, 12.6–36.9), respectively. The 1-year PFS rate was 52.3% (95% CI, 37.6–67.0%). Higher CD14+ monocyte (quartile 4 vs 1–3) and lower CD69+ γδ T cell (γδ TCR+/CD69+) levels (quartiles 1–3 vs 4) were significantly associated with poor OS (p = 0.045 and p = 0.043, respectively).

Conclusions
Neoadjuvant mFOLFIRINOX followed by postoperative gemcitabine were feasible and effective in BRPC patients. Monocyte and γδ T cells may have prognostic implications for patients with pancreatic cancer. ClinicalTrials.gov identifier: NCT02749136.
Dynamics of apomictic and sexual reproduction during primary succession on a glacier forefield in the Swiss Alps
Authors: Sailer Christian , Stöcklin Jürg , Grossniklaus Ueli 
Published: May 2020

AbstractApomixis, the asexual reproduction through seeds, is thought to provide reproductive assurance when ploidy is not even and/or when population density is low. Therefore, apomicts are expected to be more abundant, and the frequency of apomictic offspring higher, at early stages of primary succession when mates are rare. To test this hypothesis, we sampled facultative apomictic Hieracium pilosella L. along the successional gradient on a glacier forefield and determined their ploidy, the level of apomixis in their offspring, and the genetic diversity of the entire meta-population and within subpopulations. We found that apomixis is more common in odd- and aneuploid cytotypes, which are more frequent at early stages of primary succession. However, apomixis was uncommon at all successional stages and sexual hexaploids were dominating throughout. Reproductive assurance was reflected in the higher fertility of all odd-ploid apomictic plants (3×, 5×) by avoiding meiosis, illustrating that apomixis provides an escape from sterility, as proposed by Darlington. Odd-ploid plants are supposedly better colonizers (Baker’s law), which is supported by their higher occurrence close to the glacier snout. Independent of succession, we found gene flow between apomicts and sexuals, which allows for the continuous creation of new apomictic and sexual genotypes. We conclude that apomixis in H. pilosella does indeed provide an escape from sterility, and therefore reproductive assurance, in aneuploid cytotypes. We further propose that apomixis preserves beneficial combinations of unlinked alleles in every generation for as long as apomictic genotypes persist in the population.
Elevated plasma oxytocin levels and higher satisfaction with life in young oral contraceptive users
Authors: Garforth Benjamin , Degnbol Helle , Terris Elizabeth T. , Zak Paul J. , Winterdahl Michael 
Published: May 2020

AbstractOral contraception (OC) is used by approximately fifty-five million women in the USA alone and is listed as an essential medicine by the World Health Organisation. Altered mood is a common reason for OC cessation. Here we investigate the effects of OC on hormones that are linked to mood. We obtained blood samples from 185 young women (average age 21.2) in two cohorts and tested the effects of OC on plasma levels of oxytocin, adrenocorticotropic hormone (ACTH), estradiol, progesterone and testosterone. We related plasma hormone levels with self-reported measures of mood, well-being and depression. OC-users in both cohorts showed elevated basal oxytocin, lower ACTH, estradiol, progesterone and testosterone compared with non-OC users. Satisfaction With Life Score (SWLS) was higher in OC -users compared to non-OC users, with no differences in the Beck Depression Score (BDI) and Positive And Negative Affect Schedule (PANES). In conclusion, our data show alterations in hormone levels and SWLS in response to OC.
Continuously-tunable light–matter coupling in optical microcavities with 2D semiconductors
Authors: Wall Franziska , Mey Oliver , Schneider Lorenz Maximilian , Rahimi-Iman Arash 
Published: May 2020

AbstractA theoretical variation between the two distinct light–matter coupling regimes, namely weak and strong coupling, becomes uniquely feasible in open optical Fabry—Pérot microcavities with low mode volume, as discussed here. In combination with monolayers of transition-metal dichalcogenides (TMDCs) such as WS2, which exhibits a large exciton oscillator strength and binding energy, the room-temperature observation of hybrid bosonic quasiparticles, referred to as exciton–polaritons and characterized by a Rabi splitting, comes into reach. In this context, our simulations using the transfer-matrix method show how to tailor and alter the coupling strength actively by varying the relative field strength at the excitons’ position – exploiting a tunable cavity length, a transparent PMMA spacer layer and angle-dependencies of optical resonances. Continuously tunable coupling for future experiments is hereby proposed, capable of real-time adjustable Rabi splitting as well as switching between the two coupling regimes. Being nearly independent of the chosen material, the suggested structure could also be used in the context of light–matter-coupling experiments with quantum dots, molecules or quantum wells. While the adjustable polariton energy levels could be utilized for polariton-chemistry or optical sensing, cavities that allow working at the exceptional point promise the exploration of topological properties of that point.
Genomic profiling of antimicrobial resistance genes in clinical isolates of Salmonella Typhi from patients infected with Typhoid fever in India
Authors: Katiyar Amit , Sharma Priyanka , Dahiya Sushila , Singh Harpreet , Kapil Arti , Kaur Punit 
Published: May 2020

AbstractThe development of multidrug resistance in Salmonella enterica serovar Typhi currently forms a major roadblock for the treatment of enteric fever. This poses a major health problem in endemic regions and extends to travellers returning from developing countries. The appearance of fluoroquinolone non-susceptible strains has resulted in use of ceftriaxone as drug of choice with azithromycin being recommended for uncomplicated cases of typhoid fever. A recent sporadic instance of decreased susceptibility to the latest drug regime has necessitated a detailed analysis of antimicrobial resistance genes and possible relationships with their phenotypes to facilitate selection of future treatment regimes. Whole genome sequencing (WGS) was conducted for 133 clinical isolates from typhoid patients. Sequence output files were processed for pan-genome analysis and prediction of antimicrobial resistance genes. The WGS analyses disclosed the existence of fluoroquinolone resistance conferring mutations in gyrA, gyrB, parC and parE genes of all strains. Acquired resistance determining mechanisms observed included catA1 genes for chloramphenicol resistance, dfrA7, dfrA15, sul1 and sul2 for trimethoprim-sulfamethoxazole and blaTEM-116/blaTEM-1B genes for amoxicillin. No resistance determinants were found for ceftriaxone and cefixime. The genotypes were further correlated with their respective phenotypes for chloramphenicol, ampicillin, co-trimoxazole, ciprofloxacin and ceftriaxone. A high correlation was observed between genotypes and phenotypes in isolates of S. Typhi. The pan-genome analysis revealed that core genes were enriched in metabolic functions and accessory genes were majorly implicated in pathogenesis and antimicrobial resistance. The pan-genome of S. Typhi appears to be closed (Bpan  =  0.09) as analysed by Heap’s law. Simpson’s diversity index of 0.51 showed a lower level of genetic diversity among isolates of S. Typhi. Overall, this study augments the present knowledge that WGS can help predict resistance genotypes and eventual correlation with phenotypes, enabling the chance to spot AMR determinants for fast diagnosis and prioritize antibiotic use directly from sequence.
Aphid-infested beans divert ant attendance from the rosy apple aphid in apple-bean intercropping
Authors: Pålsson Joakim , Porcel Mario , Hansen Mette Frimodt , Offenberg Joachim , Nardin Tiziana , Larcher Roberto , Tasin Marco 
Published: May 2020

AbstractEcological intensification of cropping systems aims at restoring multi-functionality while supporting current productivity levels. Intercropping is a form of ecological intensification involving ecological processes beneficial to farmers that do not take place in monocultures. Thus, it represents a practical approach to decrease the use of synthetic inputs such as insecticides in cultivated systems. Whereas insecticide reduction via intercropping-facilitated suppression of aphids is reported in literature, the majority of published studies focussed on herbaceous crops. Thus, the effect of intercropping on aphid populations of cultivated trees remains largely unaddressed. In this study we hypothesized that intercropping a specific companion plant within perennial crops would divert ant attendance from an aphid attacking the crop to another aphid feeding on the newly introduced plant, reducing aphid damage on the crop. We tested our hypothesis in the system of apple (Malus domesticaBorkhausen), the rosy apple aphid (Dysaphis plantagineaPasserini) and the black garden ant (Lasius nigerL.). Bean plants (Vicia faba) with the black bean aphid (Aphis fabaeScopoli) were intercropped within apple trees inoculated withD. plantaginea. We measured ant attendance, aphid development and survival as well as honeydew composition on both plant species through semi-field and field experiments. The majority of ants chose to attendA. fabaeoverD. plantagineain the semi-field experiment with potted plants. In the orchard, a larger majority of scouts were scored onA. fabaeoverD. plantaginea. A higher number ofD. plantagineacolonies remained active in the apple control, whilst they were almost eradicated by intercropping. Although chemical analyses of honeydew disclosed differences in the carbohydrate and amino acid profiles between aphid species, the difference in honeydew composition did not explain the preference forA. fabae. Ants did not discriminate between the two honeydew mimics both in laboratory and field bioassays. Our results showed the potential of intercropping apple trees with beans as a method to reduce ant attendance and thus colony survival. We propose that intercropping represents a bottom-up approach towards ecological intensification of perennial crops. Together with other ecosystem-based measures such as habitat management, intercropping should be considered when planning ecosystem redesign to increase biological control of pests.