bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rare cause of upper gastrointestinal bleeding
Authors: Arroyo Argüelles JM , de Vicente Ortega A , Romero Moreno S , Frutos Muñoz L , Tercero Lozano M 
Published: December 2020

Resumen

Presentamos el caso de un varón que ingresa por hemorragia digestiva alta secundaria a un leiomiosarcoma retroperitoneal que infiltra duodeno.
Giant abdominal mass dependent on jejunum
Authors: Díaz Alcázar MM , Martín-Lagos Maldonado A , García Robles A 
Published: December 2020

Resumen

Mujer de 69 años que consulta por distensión abdominal de dos meses de evolución. Se realiza ecografía abdominal con hallazgo de una masa abdominal. Se completa el estudio con tomografía computarizada abdominal, observando una masa heterogénea de 26 cm de diámetro mayor, y que debido a su gran tamaño provoca el desplazamiento todas las estructuras abdominales. Se realiza exéresis de tumoración dependiente del yeyuno. El estudio histológico confirma que se trata de un leiomiosarcoma.

A pesar de que el intestino delgado abarca el 75% de la longitud total del intestino y el 90% de la superficie mucosa intestinal total, solo el 2% de los tumores malignos del tracto gastrointestinal afectan al intestino delgado, y de ellos, los leiomiosarcomas representan menos del 15%. El diagnóstico puede ser complejo, ya que produce síntomas leves e inespecíficos y el crecimiento es lento. Se trata de un tumor agresivo, por lo que el tratamiento de elección es la resección quirúrgica.
Von meyenburg complexes: an unusual discovery which was accidental
Authors: López González J , Hallouch S , Jordan Madrid TM , Campos Serrano N , Calvo Bernal MM 
Published: December 2020

Resumen

La enfermedad de los complejos von Meyenburg o microhamartomasis biliar múltiple (MBM) es una malformación biliar benigna, por la cual se forman múltiples estructuras quísticas dilatadas en la vía biliar rodeadas de un estroma fibroso. Habitualmente su diagnóstico es casual en pacientes asintomáticos.
Russian Network literature: typology and poetics
Authors: Гаджиев А.А. 
Published: December 2020

Публикуемый материал представляет собой раздел учебного пособия проф. А.А. Гаджиева «Русская сетевая литература: контекст, история, типология, поэтика [Электронный ресурс]: учебное пособие / А. Гаджиев. — Электрон. дан. и прогр. (5 Мб). — Саратов: Ай Пи Ар Медиа, 2019. — 87 с.». В нем, в свою очередь, изложено содержание спецкурса, предусматривающего изучение историко-литературного контекста, основных этапов развития, творческих особенностей и социально-правовых аспектов русской сетевой литературы.
The published material is a section of the textbook by Prof. A.A. Hajiyev «Russian network literature: context, history, typology, poetics» [Electronic resource]: textbook / A. Hajiyev. — Electron. Dan. and progr. (5 MB). — Saratov: IPR Media, 2019. — 87 p.
It outlines the content of the special course that provides for the study of the historical and literary context, the main stages of development, creative features and social and legal aspects of Russian network literature.
Cooperation between Russian secondary schools and confessional Muslim organizations in the Volga region, North Caucasus, Tyumen and Ulyanovsk regions in educational work and teaching of the «Fundamentals of religious culture and secular ethics»
Authors: Яшина О.Н. , Акказиев Р.Я. 
Published: December 2020

Авторы кратко освещают аспекты взаимоотношений между светскими школами и мусульманскими организациями в воспитательной и образовательной работе в некоторых регионах Российской Федерации, дают рекомендации по организации данной работы для московских педагогов, преподающих «Основы исламской культуры».
The authors write about aspects of the relationship between secular schools and Muslim organizations in educational work in some regions of the Russian Federation, and give recommendations on the organization of this work for Moscow teachers teaching «Fundamentals of Islamic Culture».
«Mega mendung»: an ornamental motif of Cirebon batik, Indonesia
Authors: Магдалена С. , Нур Т. 
Published: December 2020

Индонезийский батик (ручная роспись по ткани) в 2009 г. был признан ЮНЕСКО шедевром нематериального наследия человечества. Насчитывается множество видов и стилей батика, со своей техникой, орнаментальным набором, цветовой гаммой. Батик нередко служит не только символом культуры, но и этнорегиональным маркером, определяющим идентичность народов Индонезии. Один из центров производства батика, — город Чиребон, «врата Центральной Явы», разделяющий центр острова и его западную часть. Самый известный орнаментальный мотив чиребонского батика — мега мендунг, или небесно-облачный орнамент, в котором чувствуется мощное влияние китайской культуры. В китайской мифологии небо — символ божественности, свободы и величия. Мотив мега мендунг представляет собой многослойное небо. Традиционно в нем семь уровней (слоев), представленных различными цветами: от светлых и ярких до темных. Излюбленная цветовая гамма мега мендунг — синий и темно-красный. Ассоциирующиеся с мужественностью и динамизмом эти цвета отражают характер жителей побережья (Чиребон расположен на берегу Яванского моря) — это открытые, активные, легко приспосабливающиеся, веселые и счастливые люди.
Indonesian batik (hand painting on fabric) was recognized by UNESCO as a masterpiece of the intangible heritage of humanity in 2009. There are many types and styles of batik, with its own technique, ornamental set, and color scheme. Batik often serves not only as a cultural symbol, but also as an ethnoregional marker that defines the identity of Indonesian peoples. One of the centers of batik production is the city of Cirebon, the «gate of Central Java», that separates the center of the island from its western part. The most famous ornamental motif of Cirebon batik is the mega mendung, or sky-cloud ornament, which has a strong influence of Chinese culture. In Chinese mythology, the sky is a symbol of divinity, freedom, and greatness. The mega mendung motif represents a multi-layered sky. Traditionally, it has seven levels (layers), represented by different colors: from light and bright to dark. The favorite colors of a mega mendung are blue and dark red. Associated with masculinity and dynamism, these colors reflect the character of the coastal inhabitants (Cirebon is located on the coast of the Java sea) — they are open, active, adaptable, fun and happy people.
Main-sequence Scatter is Real: The Joint Dependence of Galaxy Clustering on Star Formation and Stellar Mass
Authors: Berti Angela M. , Coil Alison L. , Hearin Andrew P. , Behroozi Peter S. 
Published: December 2020

Abstract
We present new measurements of the clustering of stellar-mass-complete samples of ∼40,000 SDSS galaxies at z ∼ 0.03 as a joint function of stellar mass and specific star formation rate (sSFR). Our results confirm what Coil et al. find at z ∼ 0.7: galaxy clustering is a stronger function of sSFR at fixed stellar mass than of stellar mass at fixed sSFR. We also find that galaxies above the star-forming main sequence (SFMS) with higher sSFR are less clustered than galaxies below the SFMS with lower sSFR, at a given stellar mass. A similar trend is present for quiescent galaxies. This confirms that main-sequence scatter, and scatter within the quiescent sequence, is physically connected to the large-scale cosmic density field. We compare the resulting galaxy bias versus sSFR, and relative bias versus sSFR ratio, for different galaxy samples across 0 < z < 1.2 to mock galaxy catalogs based on the empirical galaxy evolution model of Behroozi et al. This model fits PRIMUS and DEEP2 clustering data well at intermediate redshift, but agreement with SDSS is not as strong. We show that increasing the correlation between galaxy SFR and halo accretion rate at z ∼ 0 in the model substantially improves agreement with SDSS data. Mock catalogs suggest that central galaxies contribute substantially to the dependence of clustering on sSFR at a given stellar mass and that the signal is not simply an effect of satellite galaxy fraction differences with sSFR. Our results are highly constraining for galaxy evolution models and show that the stellar-to-halo mass relation depends on sSFR.
Monte Carlo Applications for Partially Polarized Inverse External-Compton Scattering (MAPPIES). I. Description of the Code and First Results
Authors: Dreyer Lenté , Böttcher Markus 
Published: December 2020

Abstract
The radiation mechanisms responsible for the multiwavelength emission from relativistic jet sources are poorly understood. The modeling of the spectral energy distributions and light curves alone is not adequate to distinguish between existing models. Polarization in the X-ray and γ-ray regime of these sources may provide new and unique information about the jet physics and radiation mechanisms. Several upcoming projects will be able to deliver polarimetric measurements of the brightest X-ray sources, including active galactic nuclei jets and γ-ray bursts. This article describes the development of a new Monte Carlo code—MAPPIES (Monte Carlo Applications for Partially Polarized Inverse External-Compton Scattering)—for polarization-dependent Compton scattering in relativistic jet sources. Generic results for Compton polarization in the Thomson and Klein–Nishina regimes are presented.
Excitation of Spin–Orbit Misalignments in Stellar Binaries with Circumbinary Disks: Application to DI Herculis
Authors: Anderson Kassandra R. , Lai Dong 
Published: December 2020

Abstract
The large spin–orbit misalignments in the DI Herculis stellar binary system have resolved the decades-long puzzle of the anomalously slow apsidal precession rate, but raise new questions regarding the origin of the obliquities. This paper investigates obliquity evolution in stellar binaries hosting modestly inclined circumbinary disks. As the disk and binary axes undergo mutual precession, each oblate star experiences a torque from its companion star, so that the spin and orbital axes undergo mutual precession. As the disk loses mass through a combination of winds and accretion, the system may be captured into a high-obliquity Cassini state (a spin–orbit resonance). The final obliquity depends on the details of the disk dispersal. We construct a simple disk model to emulate disk dispersal due to viscous accretion and photoevaporation, and identify the necessary disk properties for producing the observed obliquities in DI Herculis. The disk must be massive (at least 10% of the binary mass). If accretion onto the binary is suppressed, the observed high stellar obliquities are reproduced with a binary–disk inclination of ∼5°–10°, but if substantial accretion occurs, the inclination must be larger, ∼20°–30°. If moderate accretion occurs, initially the disk must lose its mass slowly, but eventually lose its remaining mass abruptly, analogous to the observed two-timescale behavior for disks around T-Tauri stars. The spin feedback on the binary orbit causes the binary–disk inclination to decay as the obliquity evolves, a feature that is absent from the standard Cassini state treatment.
Absolute Monocyte and Platelet Counts May Provide Additional Prognostic Information in Primary Gastric Diffuse Large B-cell Lymphoma Patients Treated with Rituximab and CHOP
Authors: Spassov Branimir , Vassileva Donka , Nikolov Svetoslav , Ganeva Penka , Balatzenko Gueorgui , Guenova Margarita 
Published: December 2020

Introduction: Primary gastric diffuse large B cell lymphoma (PG-DLBCL) is the most common histological subtype of primary gastric lymphoma. The standard of care of PG-DLBCL patients is the combination rituximab-based immunochemotherapy (R-CHOP). Re-cently, different host-related factors have been shown to have significant prognostic significance in non-Hodgkin lymphoma. However, data regarding their prognostic contribution to PG-DLBCL are limited.&nbsp;
Aim: To assess the prognostic impact of a panel of simple, cost-effective laboratory variables which are easy to apply in routine labora-tory use for R-CHOP-treated PG-DLBCL patients in an attempt to identify those among them that are high-risk category.
Materials and methods: We retrospectively assessed the possible prognostic impact of different laboratory markers in 42 R-CHOP treated PG-DLBCL patients treated between 2004 and 2014 and followed at a single institution.
Results: The estimated 5-year overall (OS) and progression-free survival (PFS) of the whole group were 80.9% and 78%, respectively. The absolute monocyte and platelet counts in univariate analysis predicted PFS and OS when analyzed as continuous and dichotomized variables. On multivariate analysis performed with factors included in the stage-modified International Prognostic Index (m-IPI), the absolute monocyte and platelet counts remained independent predictors of PFS and OS. Therefore, the absolute monocyte and platelet counts were combined to generate a prognostic index that identified patients with an especially poor overall survival.&nbsp;
Conclusions: This prognostic index was independent of the m-IPI and could provide additional prognostic information for better stratification of these patients.
Waiting for Godot: A Cross Sectional Survey Based Analysis of the Hydroxychloroquine Prophylaxis Strategy against Covid-19 in India
Authors: Moni Merlin , Madathil Thushara , Palabatla Rahul , Balachandran Sabarish , Edathadathil Fabia , Gutjahr Georg , Madathil Sai B. , Pai Rajesh , Beena KV , Jayant Aveek , Sathyapalan Dipu T. 
Published: December 2020

Background India currently has the second largest burden of infections due to COVID-19. Health Care Worker (HCW) shortages are endemic to Indian healthcare. It should therefore be a huge priority to protect this precious resource as a critical component of the systemic response to this pandemic. Advisories from the Indian Council of Medical Research (ICMR) have focused on using hydroxychloroquine prophylaxis against COVID-19 in at risk HCW. This prophylaxis strategy has no evidence. In further jeopardy there appear to insubstantial attempts to build this evidence as well. In this connection, we commissioned a survey within our Institution to estimate the penetration of hydroxychloroquine (HCQ) use and use this to statistically model the impact of current ongoing studies in India. We also briefly review the literature on HCQ prophylaxis for COVID-19. Design and methods A structured survey designed using RedCAP application was disseminated among healthcare professionals employed at an academic referral tertiary care centre via online social media platforms. The survey was kept open for the entire month of June 2020. The survey was additionally used to statistically model the size of studies required to comprehensively address the efficacy of HCQ in this setting. Results 522 responses were received, of which 4 were incomplete. The ICMR strategy of 4 or more doses of HCQ was complete only in 15% of HCW in our survey. The majority of respondents were doctors (238, 46%). Amongst all category of responders, only 12% (n=63) received the full course. A majority of those who initiated the chemoprophylaxis with HCQ turned out to be medical professionals (59/63) with neither nurse nor other categories of healthcare workers accessing the medication. The respondents of our institutional survey did not report any life-threatening side effects. Presuming efficacy as per ICMR modelling for new registry trial on the lines of the published case control study, equal allocation between cases and controls and assuming a RR of 1.3.6, the power of such a study would be very low for n=2000 for event rates from 2.5-12.5%. Conclusion We report the low penetration of HCQ chemoprophylaxis among the healthcare workers of our institution. We highlight the inherent drawbacks in the study design of current national COVID related trial based on the statistical modelling of our survey results and published literature, and thereby emphasis the need of evidence-based strategies contributing to research policy at national level.
Treating acute myeloid leukemia among children with down syndrome
Authors: Kapoor Rajan , Mohan Karthik Ram , Roy Shuvendu , Pramanik Suman Kumar , Khera Sanjeev , Simalti A K 
Published: December 2020

Abstract
Background: Down Syndrome (DS) children with acute myeloid leukemia (AML) have unique differences in clinical features, epidemiologic nature, and biologic patterns of disease compared with AML in children without DS. Aims and Objective: AML in DS children should be considered distinct disorder from AML in Non DS population and treatment needs to be customized for this population. In this retrospective study spanning from 2014 to 2019 we present our experience of managing leukemia in children with DS. Materials and Methods: From 2014 and 2019, 72 children aged below 18 years were managed at our institute with acute myeloid leukemia (AML). Out of these 72 children with AML, 7 children were with DS which was confirmed by karyotyping. Majority of these children had M7 while M2 and M4 subtypes were seen in one child each. On conventional karyotyping in addition to trisomy 21 additional cytogenetic abnormalities were seen in 4 patients. Two children had trisomy 8. One child had deletion of 11 chromosomes and one had translocation between 8 and 21 chromosomes. Results: All 7 children were administered intensive chemotherapy with curative intent after informed parental consent. All 7 children achieved complete remission. Four out of 7 children had complications related to severe neutropenia. Conclusion: All patients of DS with AML should be offered chemotherapy with curative intent. Endeavour should be to give less aggressive chemotherapy protocol to bring down treatment related mortality.
Case Report on Autoimmune Hemolytic Anemia: A Mask of Malignancy!
Authors: Sampagar Abhilasha , Patil Neha Giridhar , Bartakke Sandip , Shrividya S 
Published: December 2020

AbstractA 10-year-old boy with autoimmune hemolytic anemia (AIHA) was treated at a local setup with repeated blood transfusions and steroids considering an idiopathic etiology. After 7 months of unresponsiveness, the child started developing recurrent fever with night sweats and pain in the abdomen which was diagnosed as tuberculosis on account of granulomatous necrotizing lesion on computed tomography (CT)-guided lymph node biopsy and treated for the same. Four months later, when the child presented to our center in anemic heart failure, work-up with positron emission tomography-CT and excisional biopsy of mesenteric lymph node led to the diagnosis of advanced Hodgkin's lymphoma with B symptoms. AIHA in pediatric age group, unlike in adults, is usually secondary. Our report stresses on a thorough evaluation of AIHA as it can mask a malignancy for a long duration and alter its course if treated with steroids, making the patient resistant to further chemotherapy.
Patient-Reported Shoulder Morbidity and Fatigue among Breast Cancer Survivors: An Insight from a Tertiary Care Cancer Hospital
Authors: Basu Abhishek , Mondal Janmenjoy , Swetha Bhukya , Chakrabarty Shinjini , Ghosh Debjit , Gangopadhyay Subhendu , Mandal Bidyut 
Published: December 2020

Abstract
Context: Breast cancer is the most common cancer in Indian women with an annual mortality of around 87,000. Treatment for breast carcinoma may lead to swelling of the ipsilateral arm, shoulder stiffness, arm pain, and cancer-related fatigue. Very few centers in India have reported the arm and shoulder morbidity treated in their hospitals. Aims: The aim was to evaluate the predictive factors of arm and shoulder morbidity and fatigue among breast cancer survivors. Settings and Design: This was a retrospective analysis based on a prospectively maintained database. Materials and Methods: Early and locally advanced cases of breast cancer patients were screened for the study during 2015–2018. Eligible participants were invited to fill up the predetermined questionnaire, and their demographic and treatment-related information was accrued from a file archive. Follow-up period was estimated from the date of tissue diagnosis to last contact/time of interview. Results: Shoulder stiffness was the most common complaint followed by arm numbness. Obesity and diabetes played a crucial role in most of the morbidities and fatigue. The median fatigue score was 34, and the median time of appearance of lymphedema was 13 months. Modified radical mastectomy and radiotherapy to axilla were statistically significantly (P = 0.04 and 0.01, respectively) associated with greater shoulder stiffness and arm swelling. Conclusions: Obesity, diabetes, type of surgery, the extent of axillary dissection, and radiation plan are the major predictive factors of arm and shoulder morbidity. Further prospective validation is necessary for future breast cancer survivorship programs.
Antibody Drug Conjugates
Authors: Bala Stalin , Prasad Siva K 
Published: December 2020

AbstractAntibody drug conjugates (ADCs) are chemically engineered drugs consisting of monoclonal antibody (mAb) and cytotoxic compound attached chemically by a linker. Upon attachment to a specific target antigen, ADC enters into the cell and payload is released, which finally leads to cell killing. Payloads are broadly divided into tubulin-disrupting agents and DNA-damaging agents. Most of the current ADCs utilize humanized mAbs, and fully human mAbs are under investigation. ADC development process is accelerated by better designing and bio-engineering methods.