bluuebunny/crossref_metadata_2025_split huggingface dataset:
Connectedness among stocks and tail risk: Evidence from China
Authors: Hu Zhijun , Sun Ping‐Wen 
Published: July 2020

AbstractApplying the market tail risk measure proposed by Kelly and Jiang in the China's A‐shares market, we find that the monthly market tail risk significantly and negatively predicts the monthly industrial output growth rate up to 1 year. In addition, from July 2007 to June 2019, we find that stocks with a higher tail risk outperform stocks with a lower tail risk by 0.62% (0.30% after risk adjustment) per month. Using the institutional holding weight within an industry and correlations in return on assets as proxies for the connectedness among stocks associated with firm fundamentals, and treating the sentiment risk and correlations in the three factor risk‐adjusted residuals as proxies for the connectedness among stocks associated with investor sentiment, we further show that the connectedness among stocks significantly affects individual stocks' tail risk and tail risk premium. Moreover, our findings show that the connectedness components of tail risk associated both with firm fundamentals and with investor sentiment can significantly and positively predict stock returns. Our finding suggests that the connectedness among stocks provides an important channel through which firm fundamentals and investor sentiment influence the tail risk premium in the China's A‐shares market.
Prediabetes and long‐term outcomes in patients with three‐vessel coronary artery disease: A large single‐center cohort study
Authors: Yuan Deshan , Zhang Ce , Jia Sida , Jiang Lin , Xu Lianjun , Zhang Yin , Xu Jingjing , Xu Bo , Hui Rutai , Gao Runlin , Gao Zhan , Song Lei , Yuan Jinqing 
Published: July 2020

AbstractAims/IntroductionWhether detection of prediabetes by routinely testing hemoglobin A1c and fasting plasma glucose in three‐vessel disease patients could identify individuals at high risk of future cardiovascular disease events remains unclear. This study evaluated the relationship between different glycemic status and clinical outcomes in this specific population.Materials and MethodsThis study included 8,891 Chinese patients with three‐vessel disease. Patients were categorized according to their glycemic status (normoglycemia [NG], n = 3,195; prediabetes, n = 1,978; diabetes mellitus, n = 3,718).ResultsThe median follow‐up time was 7.5 years, during which 1,354 deaths and 2,340 major adverse cardiac and cerebrovascular events occurred. Compared with the NG group, patients in the prediabetes and diabetes mellitus groups had more comorbidities. After adjusting for confounders, the diabetes mellitus group had a higher risk of all‐cause death (hazard ratio [HR] 1.36, 95% confidence interval [CI] 1.20–1.53; P < 0.001), cardiac death (HR 1.35, 95% CI 1.14–1.61; P = 0.001) and major adverse cardiac and cerebrovascular events (HR 1.22, 95% CI 1.11–1.34; P < 0.001) compared with the NG group, whereas the prediabetes and NG groups had no significant difference. The diabetes mellitus group also had a higher risk of stroke compared with the NG group (HR 1.22, 95% CI 1.02–1.46; P = 0.031).ConclusionsIn the context of three‐vessel disease, prediabetes patients have comparable long‐term outcomes in terms of major adverse cardiac and cerebrovascular events, cardiac death and all‐cause death to those with NG. Routine screening of glycemic metabolism based on hemoglobin A1c and fasting plasma glucose might be valuable to identify individuals with diabetes mellitus who are at high risk of future cardiovascular disease events and individuals with prediabetes who are at high risk of progressing to diabetes mellitus.
Bilateral atrophy of the extensor digitorum brevis muscle might be a useful sign for diagnosing diabetic polyneuropathy in Japanese men who do not sit in the traditional “seiza” style
Authors: Kishimoto Shohei , Sasaki Hideyuki , Kurisu Seigo , Ogawa Kenichi , Matsuno Shohei , Furuta Hiroto , Arita Mikio , Naka Keigo , Nanjo Kishio , Akamizu Takashi 
Published: July 2020

AbstractAims/IntroductionAs the extensor digitorum brevis muscle is a small muscle in the most distal part of the legs, its atrophy (EDBA) might reflect symmetric polyneuropathy (SPN). We aimed to clarify the EDBA‐related factors and the usefulness of bilateral EDBA detection for diagnosing SPN, especially diabetic SPN (DSPN).Materials and MethodsIn 1,893 participants from the Japanese general population (investigation I) and 133 established diabetes patients (investigation II), relationships between EDBA and various factors including the traditional sitting style called “seiza’” (kneeling and sitting on one’s heels) were investigated. Analyses were carried out by univariate and multivariate analysis, and SPN or DSPN was diagnosed by the criteria of “Probable DSPN” of the Toronto Consensus. The validity of EDBA detection for diagnosing SPN/DSPN was also evaluated.ResultsInvestigation I: EDBA was more prevalent in women than men (44% vs 20%). Significant EDBA‐related factors were aging and seiza habit regardless of sex. Male‐specific EDBA‐related factors were SPN and known diabetes. In men without seiza habit, EDBA was significantly associated with SPN regardless of diabetes, so EDBA seemed to be a useful sign for diagnosing SPN/DSPN. Investigation II: In men, DSPN was more prevalent in the EDBA group than the non‐EDBA group (71% vs 33%). Sensitivity, specificity, positive predictive value and kappa coefficient of EDBA detection for diagnosing DSPN were 44, 87, 67% and 0.323, showing fair agreement.ConclusionsEDBA detection might be a useful method to screen for distal symmetric polyneuropathy, such as DSPN in men, although the exclusion of individuals with seiza habit is necessary to improve accuracy.
Analysis of intermittent infrared drying using heat recovery with a novel control methodology
Authors: Dolgun Ekin Can , Karaca Gülşah , Aktaş Mustafa , Kılıç Faruk 
Published: July 2020

AbstractDrying is one of the most energy consuming process. By using automatic control systems in the industry, a higher quality and energy efficient drying is achieved. There are two main periods in drying process, the constant rate period and the falling rate period. In the falling rate period, it becomes difficult to evaporate water from the product, and this results in high specific energy consumption values and low energy efficiency values. In this study, apple slices were dried in an intermittent infrared dryer with two new developed drying methodologies as a solution to this problem (Model 2 and 3). An Arduino based automatic control system was used for Model 2 and Model 3. Developed models were compared with conventional experiments (Model 1). With Model 2, a constant drying rate was achieved independently of the moisture content. With Model 3, 57% shorter drying time compared to Model 2 and 16% less energy consumption compared to Model 1 was provided. Also using of the Model 3 the energy efficiency increased as 50% and the specific energy consumption decreased as 48% compared to Model 1. This study offers a solution with high efficiency in industrial usage.Practical ApplicationsConventional dryers have low energy efficiency and high specific energy consumption. With two novel drying methodologies developed within the scope of this study, a reduction of 16% in energy consumption and increase of 50% in energy efficiency were observed as an alternative to conventional drying. In addition, a constant drying rate was achieved independently of the moisture content. These drying methodologies offer an applicable solution for drying process with high energy efficiency in industrial food drying systems. Thus, it is foreseen to decrease the energy consumption and increase the efficiency in the drying industry, which constitutes a large part of the industrial energy consumption.
Anti‐Müllerian hormone and antral follicle count differ in their ability to predict cumulative treatment outcomes of the first complete ovarian stimulation cycle in patients from POSEIDON groups 3 and 4
Authors: Liu Luxin , Zhou Canquan 
Published: July 2020

AbstractAimTo explore the ability of anti‐Müllerian hormone and antral follicle count to predict cumulative live birth and clinical pregnancy in the first complete ovarian stimulation cycle among patients from POSEIDON (Patient‐Oriented Strategies Encompassing IndividualizeD Oocyte Number) groups 3–4.MethodsA single‐center retrospective study was conducted on 260 patients in POSEIDON groups 3–4 (antral follicle count <5 and/or anti‐Müllerian hormone <1.2 ng/mL) who first underwent complete in vitro fertilization/intracytoplasmic sperm injection cycles between January 2016 and June 2018. The main outcomes were cumulative live birth rate and cumulative clinical pregnancy rate.ResultsOf 260 patients, 113 (43.5%) achieved clinical pregnancy and 82 (31.5%) achieved live birth in their first complete ovarian stimulation cycles. With multivariate regression analysis, age and antral follicle count were significantly correlated with cumulative clinical pregnancy, whereas age and anti‐Müllerian hormone were significantly associated with cumulative live birth. Receiver operating characteristic curve analysis demonstrated that age had the highest accuracy for the prediction of cumulative treatment outcomes. The optimal cut‐off value of age was 40.5 and that of antral follicle count was 2.5 for predicting cumulative clinical pregnancy. The optimal cut‐off value of age was 36.5 and that of anti‐Müllerian hormone was 0.725 for predicting cumulative live birth.ConclusionOur findings indicate that anti‐Müllerian hormone is a better predictor of cumulative live birth than antral follicle count, independent of age, in the first complete ovarian stimulation cycle of in vitro fertilization/intracytoplasmic sperm injection among patients in POSEIDON groups 3–4.
Deliberative control in audiovisual sociolinguistic perception*
Authors: Campbell‐Kibler Kathryn 
Published: July 2020

AbstractCognitive models of sociolinguistics must support a wide range of goal‐oriented behavior (e.g. Eckert, 2000a) without suggesting unrealistic levels of deliberative control on the part of speakers. The current study investigates the limits of deliberative control in audiovisual face‐voice perception. Perceivers evaluated co‐present recorded speech and static face pictures, rating the stimuli on the scales ‘accented’ and ‘good‐looking’ in one of three conditions: as a combined voice and face; evaluating the face while ignoring the voice; and evaluating the voice while ignoring the face. Perceivers' ability to ignore social information from a face or voice upon instruction are taken as indicative of deliberative control in social evaluation. The results suggest that deliberative control and evaluative relevance both play a role in perception, but that available social information is difficult to ignore completely. They further suggest an asymmetry making voices more difficult to ignore than static faces and support a model of sociolinguistic perception and evaluation as a function of multiple competing processes under varying degrees of deliberative control.
Acquired factor V inhibitors after allogeneic hematopoietic stem cell transplantation in a dog
Authors: Masciana Joseph , Peterson Nathan , Chretin John 
Published: July 2020

AbstractObjectiveDescribe the clinical course and management of a dog that underwent hematopoietic stem cell transplantation (HSCT) for treatment of B‐cell lymphoma and developed acquired circulating factor V (FV) inhibitors.Case SummaryAn 8‐year‐old male castrated Briard dog diagnosed with lymphoma (IVb, B‐cell) presented for allogeneic HSCT. Despite multiple platelet, fresh frozen plasma, and red blood cell transfusions prolonged recovery and clinical bleeding occurred. Circulating acquired FV inhibitors were identified and hemorrhage subsequently was managed by immunosuppression. The dog was discharged when clinical resolution of bleeding was achieved.New or Unique Information ProvidedThis case report describes a dog undergoing curative intent treatment for lymphoma, and subsequently acquiring factor inhibition, and was successfully managed. Specific coagulation screening to assess for coagulation factor deficiencies or inhibitors is essential in the diagnosis and treatment of patients with refractory bleeding or only transient response to blood transfusion.
Utility of radiographic measurements to predict echocardiographic left heart enlargement in dogs with preclinical myxomatous mitral valve disease
Authors: Poad Megan H. , Manzi Timothy J. , Oyama Mark A. , Gelzer Anna R. 
Published: July 2020

AbstractBackgroundEvaluation of left heart size helps determine disease severity in dogs with myxomatous mitral valve disease (MMVD).Hypothesis/ObjectivesDetermine the ability of radiographic vertebral heart size (VHS) and vertebral left atrial size (VLAS) to predict LHEECHOin dogs with preclinical MMVD.AnimalsSeventy client‐owned dogs with MMVD and no historical or present clinical or radiographic evidence of congestive heart failure (CHF).MethodsRetrospective cross‐sectional study of dogs with same‐day echocardiography and thoracic radiography. Receiver‐operating characteristic (ROC) curves were used to assess the ability of VHS, VLAS, and VHS + VLAS to discern dogs with and without LHEECHO, and clinically relevant cutpoints for these radiographic measurements were selected.ResultsThe ability of VHS and VHS + VLAS to predict LHEECHOwas moderate (area under the curve [AUC]VHS= 0.851; 95% CI, 0.762‐0.941; AUCVHS + VLAS= 0.865; 0.783‐0.947), and performance of VLAS and VHS + VLAS was not different from that of VHS alone. A VHS cutpoint of >10.8 had sensitivity = 91.1% (76.3%‐98.1%) and specificity = 69.4% (51.9%‐83.7%) for predicting LHEECHO. A cutpoint of >11.7 had sensitivity = 32.4% (17.4%‐50.5%) and specificity = 97.2% (85.5%‐99.9%) for predicting LHEECHO. Thirty (43%) of the 70 dogs had a VHS value of 10.9 to 11.7.Conclusions and Clinical ImportanceVertebral heart size >11.7 identified dogs with LHEECHOand VHS ≤ 10.8 excluded dogs with LHEECHO. A large percentage of dogs had VHS values intermediate to these cutpoints.
Therapeutic interventions to restore microcirculatory perfusion following experimental hemorrhagic shock and fluid resuscitation: A systematic review
Authors: van Leeuwen Anoek L. I. , Dekker Nicole A. M. , Jansma Elise P. , Boer Christa , van den Brom Charissa E. 
Published: July 2020

AbstractObjectiveMicrocirculatory perfusion disturbances following hemorrhagic shock and fluid resuscitation contribute to multiple organ dysfunction and mortality. Standard fluid resuscitation is insufficient to restore microcirculatory perfusion; however, additional therapies are lacking. We conducted a systematic search to provide an overview of potential non‐fluid‐based therapeutic interventions to restore microcirculatory perfusion following hemorrhagic shock.MethodsA structured search of PubMed, EMBASE, and Cochrane Library was performed in March 2020. Animal studies needed to report at least one parameter of microcirculatory flow (perfusion, red blood cell velocity, functional capillary density).ResultsThe search identified 1269 records of which 48 fulfilled all eligibility criteria. In total, 62 drugs were tested of which 29 were able to restore microcirculatory perfusion. Particularly, complement inhibitors (75% of drugs tested successfully restored blood flow), endothelial barrier modulators (100% successful), antioxidants (66% successful), drugs targeting cell metabolism (83% successful), and sex hormones (75% successful) restored microcirculatory perfusion. Other drugs consisted of attenuation of inflammation (100% not successful), vasoactive agents (68% not successful), and steroid hormones (75% not successful).ConclusionImproving mitochondrial function, inhibition of complement inhibition, and reducing microvascular leakage via restoration of endothelial barrier function seem beneficial to restore microcirculatory perfusion following hemorrhagic shock and fluid resuscitation.
Raloxifene Prevents Early Periprosthetic Bone Loss for Postmenopausal Women after Uncemented Total Hip Arthroplasty: A Randomized Placebo‐Controlled Clinical Trial
Authors: Gong Long , Zhang Yao‐yao , Yang Na , Qian Huan‐juan , Zhang Ling‐kun , Tan Ming‐sheng 
Published: July 2020

ObjectiveTo examine the results of raloxifene for prevention of periprosthetic bone loss around the femoral stem in patients undergoing total hip arthroplasty (THA).MethodsBetween January 2015 and May 2017, 240 female patients between 55 and 80 years underwent primary THA and were randomly allocated to receive 60 mg raloxifene hydrochloride per day (treatment group, TG, n = 120) or placebo (control group, CG, n = 120) orally at bedtime using computer‐generated randomization sequence generation. Baseline data, the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), women's quality of life (QoL) score, bone mineral density (BMD) around the prosthesis, and adverse events were compared between the two groups. The measuring range of BMD around the prosthesis was divided into seven regions of interest (ROI). The sample size was calculated to detect a mean difference in BMD of 0.15 g/cm2 with a standard deviation (SD) of 0.3. The error was set at 0.05 and the power level at 90% with additional compensation for a possible dropout rate of 20%.ResultsA total of 240 participants in the study up to 24 months after THA. There were no significant differences in the mean BMD of all the zones between groups before surgery (all P > 0.05). However, there were significant differences in the BMD of Gruen zones 4 and 7 between groups at 6 months postoperatively (both P < 0.05); there were significant differences in Gruen zones 1, 4, 6, and 7 at 12 months postoperatively (all P < 0.01); there were significant differences in Gruen zones 1, 2, 4, 6, and 7 at 24 months postoperatively (all P < 0.001). Patients taking raloxifene reported higher QoL scores, with better improvement in BMD in all areas except in zones 3 and 5 compared with the control group. There were no significant differences in WOMAC pain (P = 0.4045), WOMAC function (P = 0.4456) and women's QoL scores (P = 0.5983) between groups before surgery. However, WOMAC pain, WOMAC function and women's QoL score in the treatment group were significantly better at all time points (all P < 0.05). Patients in the treatment group showed no increased adverse events, including cardiac events, stroke, venous thromboembolism, and gynecological cancer (all P > 0.05), but did show decreased odds of breast cancer in comparison with those using a placebo (P = 0.0437).ConclusionRaloxifene can help inhibit bone loss around the prosthesis and improve the QoL of postmenopausal women after THA with no increased adverse events, and can even decrease the odds of breast cancer.
Are we underestimating overweight and obesity prevalence in children?
Authors: Laurent Jennifer S. , Tompkins Connie L. , Cioffredi Leigh‐Anne , Wollenburg Emelia , Smith Denise , Fontaine Elisabeth 
Published: July 2020

AbstractObjectiveTo objectively determine the prevalence of overweight and obesity in elementary school children in two rural counties in Vermont prior to implementing a community‐based intervention.MethodsSchool‐based objective measures of body mass index (BMI) were obtained from 1,688 public school children in first, third, and fifth grades in two Northern Vermont counties in the Fall of 2017.ResultsForty‐one percentage of elementary school children were either overweight or obese, nearly double the estimated Vermont prevalence rate of 22.2%. Schools located in more rural areas showed higher levels of overweight and obesity in children than schools in less rural areas in these northern counties (p < .005).ConclusionsIndirect and self‐reported measures of BMI may be underestimating the true prevalence of overweight and obesity particularly in more rural communities.Policy implicationsData presented here in which children were measured directly by trained study staff demonstrate that the prevalence of obesity among children in elementary school is alarmingly high. Accurate, ongoing BMI measurement surveillance is one tool to better understand both the current trends in childhood overweight and obesity and the effect of community and state interventions.
Can vasohibin‐1, an endothelium‐derived angiogenesis inhibitor, be a marker of endothelial dysfunction in hemodialysis patients?
Authors: Altunoren Orcun , Kerkutluoglu Murat , Sarısık Feyza Nur , Akkus Gulsum , Seyithanoglu Muhammed , Doganer Adem , Tutuncu Sezal Didem , Cagrı Aykan Ahmet , Eren Necmi , Erken Ertugrul , Gungor Ozkan 
Published: July 2020

AbstractBackgroundEndothelial dysfunction (ED) is associated with high cardiovascular disease burden in hemodialysis (HD) patients. Vasohibin‐1, an endothelium‐derived angiogenesis inhibitor, is essential for endothelial cell survival, therefore it may be a promising marker of ED. We aimed to investigate whether vasohibin‐1 levels are associated with ED markers in HD patients.MethodsFifty HD patients and 30 healthy controls were included in the study. As markers of ED, endothelium‐dependent flow‐mediated dilatation (FMD), carotid intima‐media thickness (CIMT), and pulse wave velocity (PWV) were examined. Serum vasohibin‐1 levels were measured with ELISA.ResultsSerum vasohibin‐1 levels were low (387.7 ± 115.7 vs 450.1 ± 140.1 P = .02), FMDs' were impaired (6.65 ± 2.50 vs 10.95 ± 2.86 P < .001), PWV (7.92 ± 1.964 vs 6.79 ± 0.96 P = .01) and CIMT (0.95 ± 0.20 vs 0.60 ± 0.11 P < .001) were increased in HD patients compared to healthy controls. In regression analysis, vasohibin‐1 levels were not related with FMD, PWV, or CIMT.ConclusionsHemodialysis patients have low serum vasohibin‐1 levels but serum levels of vasohibin‐1 did not show any significant relationship with FMD, PWV, and CIMT in HD patients. Since vasohibin‐1 acts via paracrine pathways, serum levels may be insufficient to explain the relationship between vasohibin and ED. Local vasohibin‐1 activity on tissue level may be more important instead of circulating levels.
Ideological rupturing
Authors: Head James Christopher 
Published: July 2020

AbstractSeeking to rectify the asocial nature of conventional social psychological investigation, some researchers and scholars have sought ways to better understand what is shared in everyday thinking and have, accordingly, focused their attention on the notion of ideology. Although this vein of scholarship has reclaimed the social domain, it has not thoroughly accounted for the way that ideologies can be imposed, and as such, does not adequately address the concept in a way that honors its origin and development. In this paper, I articulate a conceptual framework that can be used to underpin research on momentary ideological impositions in relation to people's negotiation of imposed value orientations—moments that can be described as instances of ideological rupturing. After situating this articulation in relation to the work of other ideology‐focused psychologists, I introduce a recent enactment of educational policy as an illustrative case of ideological rupturing. In so doing, I present a narrative approach that is grounded in dialogic activity as an ideal way to investigate instances of ideological rupturing.