bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and radiological features of immune checkpoint inhibitor-related pneumonitis in lung cancer and non-lung cancers
Authors: Nobashi Tomomi W , Nishimoto Yuko , Kawata Yujiro , Yutani Hidetaka , Nakamura Masaki , Tsuji Yuichi , Yoshida Atsushi , Sugimoto Akihiko , Yamamoto Takayuki , Alam Israt S , Noma Satoshi 
Published: August 2020

Objective:To investigate the clinical and radiological features of immune checkpoint inhibitor-related pneumonitis (ICI-P), a rare but serious pulmonary complication of cancer immunotherapy and to evaluate key differences between lung cancer (LC) and non-LC patients.Methods:247 patients (LC, n = 151) treated with ICI for malignancies were retrospectively screened in a single institute. The number of patients, history of other immune-related adverse events (irAE), the onset, serum KL-6 levels, and chest CT features (types of pneumonitis, symmetry, laterality, location) were recorded for the ICI-P population and compared for LC and non-LC groups.Results:ICI-P was identified in 26 patients in total (LC, n = 19; non-LC, n = 7). The incidence of other irAE was significantly higher in ICI-P group (63%) compared with patients without ICI-P (34%) (p = 0.0056). An earlier onset of ICI-P was recorded in LC (78 days) compared to non-LC patients (186 days) (p = 0.0034). Serum KL-6 was significantly elevated only in the non-LC group when ICI-P was noticed (p = 0.029). Major CT findings of ICI-P, irrespective of primary disease, were organizing pneumonia pattern and ground glass opacities. LC patients commonly exhibited consolidation and traction bronchiectasis and were prone to asymmetrical shadows (p < 0.001). Non-LC patients were more likely to exhibit symmetrical infiltrations. A small fraction of both groups experienced relapse or moving patterns of ICI-P.Conclusion:ICI-P patients more often experienced other irAE prior to the development of ICI-P. The characteristics of ICI-P can differ in terms of the onset, KL-6 reliability, and chest CT findings between LC and non-LC patients.Advances in knowledge:In ICI-P patients, a history of other irAE can be more frequently observed. Differences in disease onset and radiological patterns between LC and non-LC patients might be helpful to make a diagnosis of ICI-P; however, longitudinal observation of chest CT scans is advised to observe the pneumonitis activity irrespective of cancer types.
Um novo modelo para as escolas de administração
Authors: Wood JR. Thomaz , Caldas Miguel P. , De Souza Renato José 
Published: August 2020

Para responder às demandas sociais atuais, as escolas de Administração devem retomar seu ideário original, romper com o modelo anacrônico vigente, com silos de pesquisa e ensino, e adotar um modelo fundado na gestão e disseminação do conhecimento.
O poder da ação
Authors: Azevedo Lia 
Published: August 2020

Há tempos se fala em empoderamento da mulher, promoção da diversidade, inclusão de pessoas com deficiência. Chegou a hora de encerrar a era do discurso e iniciar a da ação. Assim, de fato, veremos os ponteiros se movimentarem para termos maisrepresentatividade e uma sociedade mais justa.
Hora de mudar
Authors: Wilner Adriana , Dos Santos Aline Lilian 
Published: August 2020

Trabalhar em grandes empresas ou empreender? A dúvida, comum entre muitos estudantes quando terminam a faculdade, também ficou martelando a cabeça de Dennis Wang. Graduado em Administração Pública pela Escola de Administração de Empresas de São Paulo, da Fundação Getulio Vargas (FGV EAESP), em 2005, ele conseguiu resolver o dilema fazendo ambos. Depois de ganhar experiência nos bancos ABN Amro, BNP Paribas e Merrill Lynch, entrou no mundo das startups, ocupando posições como co-chief executive officer (coCEO) da Easy Taxi, vice-presidente de operações do Nubank, entre outras.Foi num primeiro período sabático que conseguiu fazer essa transição de grandes instituições financeiras para o mundo do empreendedorismo. “Tive que tomar esse risco para mudar”, diz. Agora, Dennis entra em um segundo intervalo na carreira, o que, para ele, é uma oportunidade de se autoconhecer e estar mais atento às oportunidades. Nesta entrevista à GV-executivo, o ex-aluno da EAESP fala sobre as mudanças na carreira e como vê as startups de tecnologia hoje.
Effect of rehabilitation training on an elderly population with mild to moderate hearing loss: study protocol for a randomised clinical trial
Authors: Rasouli Fard Parisa , Jarollahi Farnoush , Sameni Seyyed Jalal , Kamali Mohammad 
Published: August 2020

Background: Age-related hearing loss (presbycusis) is a form of hearing loss in over 60-year-olds and has a negative impact on quality of life. The pathophysiology of presbycusis is multifactorial and is predominately characterised with a loss of speech perception in noise. In the cochlea, auditory filters decompose broadband sound into a series of narrowband output signals, which contains two kinds of temporal information: slow changes in overall amplitude envelope (ENV) and faster variations in temporal fine structure (TFS). TFS is important for recognition of target speech in noise. The main aim of the study is to evaluate the effect of TFS rehabilitation training in participants over the age of 60 years with mild to moderate hearing loss. Methods: A randomised clinical trial conduct on 30 participants with mild (loss of 20-39dB) to moderate (40-69dB) hearing loss, aged between 60 and 75 years old. Participants with conductive hearing loss, abnormal middle ear pathology and central nerve system disease were excluded. Participants were randomly selected to an intervention and control group with a 1:1 ratio. Rehabilitation for the intervention Group are 30-minute sessions three times a week for a total five weeks of vowel consonant vowel words that are used to eliminate ENV and keep only TFS. Word in noise test, binaural TFS test, and Speech, Spatial and Qualities of Hearing Scale scores are performed at the beginning and end of study to evaluate the effect of rehabilitation training. Conclusion: Life expectancy in the elderly has improved, leading to an increased prevalence of age-related diseases including presbycusis. A literature review highlighted that TFS damage is permanent; however, in this study we will attempt to prove that TFS training may lead to speech in noise perception restored. Trial registration: Registry of Clinical Trials, IRCT2019625044006N1 (7th August 2019).
Light source for comfortable lighting and trapping pests in tea gardens based on solar-like lighting
Authors: Chen Yi-Di , Wang Jia-Chen , Zhang Jing-Hui , Cao Guan-Ying 
Published: August 2020

A large amount of tea is produced every year. Tea is often harmed by pests during the cultivation process, causing great economic damage. In this paper, we simulated a kind of light source for comfortable lighting and trapping pests based on solar-like lighting. We investigated three combinations of white LEDs and monochromatic LEDs for solar-like trapping light. The optimal combination of white LEDs and monochromatic LEDs was determined by the production cost and the spectral phototaxis ratio. We used TracePro for the trapping light mixing design. The results show that the combination of the cold white LED and six kinds of monochromatic LEDs is the best for trapping pests. A light source for comfortable lighting and trapping pests based on solar-like lighting with the color temperature of 7285 k, color coordinates of (0.3052, 0.3031), and color rendering index of 70 is obtained. The trapping light can not only be used as functional lighting but can also be applied to reduce the use of pesticides and improve the quality of tea.
Radiation-resistant flatness-shaped spectrum erbium-doped photonic crystal fiber source employing multiple self-compensating methods
Authors: Suo Xinxin , Yu Haicheng , Li Jing , Liu Yuanyuan , Wu Xudong 
Published: August 2020

A novel scheme of radiation-resistant flatness-shaped spectrum erbium-doped photonic crystal fiber source (EDPCFS) employing multiple self-compensating methods is proposed. We first develop a sort of radiation-resistant highly erbium-doped photonic crystal fiber (EDPCF) with the cutoff wavelength of 520 nm, which ensures that the pump light and most energy of the green light from upconversion of

E
r

3
+

could participate in photo-annealing to reduce the radiation-induced background attenuation (RIBA) of the EDPCFS under radiation environment. To minimize the spectrum variation from radiation-induced active band attenuation (RIABA), the original spectrum is optimized employing an improved double pumped backward (DPB) configuration. With a gain flattening filter and closed-loop feedback control technology, a radiation-resistant EDPCFS with a linewidth larger than 41 nm is achieved, and it experimentally demonstrates a significantly improved mean-wavelength stability of 0.42 ppm/krad with the output power attenuation of 0.09 dB under

γ

-irradiation of 200 krad. The novel radiation-resistant EDPCFS proposed is quite feasible for strategic interferometric fiber-optic gyroscopes (IFOGs) working in high-dose radiation environment.
Miniature all-fiber force sensor
Authors: Pevec Simon , Donlagic Denis 
Published: August 2020

A miniature all-fiber Fabry–Perot sensor for measurement of force is presented in this Letter. The sensor consists of a thin silica diaphragm created at the tip of the fiber. The central part of the diaphragm is extended into a silica pole, which is ended with a round-shaped probe or a sensing cylinder apt for asserting measured force. The entire sensor is made of silica glass and has a cylindrical shape with a length of about 800 µm and a diameter of about 105 µm. Force sensing resolution of about 0.6 µN was demonstrated experimentally while providing an unambiguous sensor measurement range of about 0.6 mN. The sensor is shown for measurements of surface tension of liquids and biological samples examination.
THE NEED FOR KNOWLEDGE AND USE OF VACCINES FOR THE MAINTENANCE OF GLOBAL HEALTH AND DEVELOPMENT OF COUNTRIES
Authors: Ribeiro Maria Natália Alves , Coelho José Leonardo Gomes , Veras Helenicy Nogueira Holanda , Sampaio Juliana Ribeiro Francelino , Saraiva Emanuela Machado Silva , Santana Willma José de 
Published: August 2020

Gulobalization promotes changes throughout the world scenario, some not very positive, such as the ease of spreading infectious diseases that threaten global health among different places, which calls for the use of immunization means -see vaccines- so that countries can develop, maintaining health security. The aim of this commentary is to analyze the historical relationship between world well-being and vaccine production. The methodology used was based on studies related to the theme, from 2014-2020, in the languages Portuguese, English and Spanish. The following descriptors were used: vaccines, globalization and health, immunization. This comment is expected to briefly describe the types of vaccines and their importance for maintaining global well-being. Keywords: vaccines, globalization and health, immunization, global health.
Interactions between adsorbents and adsorbates in aqueous solutions
Authors: Wu Zhijian , Ye Xiushen , Liu Haining , Zhang Huifang , Liu Zhong , Guo Min , Li Quan , Li Jun 
Published: August 2020

Abstract
Adsorption is one of the most widely used processes in physicochemical operations. To design an adsorbent for a specific adsorbate, it is important to understand the interactions between adsorbents and adsorbates, which are very important for both adsorption capacity and selectivity. Electrostatic interactions, hydrogen bonding, hydrophobic interactions, complexation, and precipitation are comprehensively discussed. Adjusting solution pH and ionic strength is an effective method to improve the adsorption, especially when electrostatic and hydrophobic interactions are main interactions. With the increase in ionic strength, the hydrophobic interactions between adsorbents and adsorbates increase, while the electrostatic interactions decrease.
Real-time in-situ 1H NMR of reactions in peptide solution: preaggregation of amyloid-β fragments prior to fibril formation
Authors: Okamura Emiko , Aki Kenzo 
Published: August 2020

Abstract
In-situ analytical methods are essential for the reliable observation of peptide reactions without perturbation of the system. In this work, a real-time in-situ NMR analysis was performed to gain insight into the initial stage of the aggregation of amyloid-beta (Aβ) 8–25 monomers, S8GY10EVHHQKLVFF20AEDVG25, in solution prior to the fibril formation. NMR chemical shift and intensity changes in combination with the CD spectra revealed no changes in Aβ secondary structure, but the presence of soluble, oligomeric intermediates followed by the appearance of insoluble and non-structured aggregates before β-fibril formation. Molecular views of intermediates and aggregation mechanisms were proposed in comparison with NMR spectral changes in wild-type Aβ 8–25 and its two mutants, A21G and E22G. The mutation of just one amino acid modified the aggregation properties of Aβ 8–25; it slowed or accelerated the fibril formation by controlling the progress of conversion from monomer to aggregate via a soluble, small oligomer.
Decomposition Moisture—The Hidden Reactive Constituent in Coal
Authors: Riley John T. , Marsh Mason , Darling Adam 
Published: August 2020

Abstract
When coals are heated to temperatures of 200°C–250°C, moisture from the decomposition of organic materials, such as humic acids, is driven off. This moisture is decomposition moisture. Very little information is known about decomposition moisture, and there are no known examples of the quantification of this type of moisture in coal. The amount of decomposition moisture in coal is assumed to be relatively small. Recent studies involving the rapid drying of coal have shown that moisture that evolves around 200°C plays a significant role in the determination of the volatile matter yields of most ranks of coal. It is assumed that this moisture is decomposition moisture. A series of experiments were performed to study this moisture, including how to identify and quantify it. Analytical techniques including thermogravimetric analysis, derivative thermogravimetry, and carbon and hydrogen analysis were employed in the study. All these techniques were needed to quantify the decomposition moisture evolved from various ranks of coal. The decomposition moisture in the coals studied ranged from 0.03 to 2.07 %.
177Lu-DOTATATE therapy in metastatic/inoperable pheochromocytoma-paraganglioma
Authors: Jaiswal Sanjeet Kumar , Sarathi Vijaya , Memon Saba Samad , Garg Robin , Malhotra Gaurav , Verma Priyanka , Shah Ravikumar , Sehemby Manjeet Kaur , Patil Virendra A , Jadhav Swati , Lila Anurag Ranjan , Shah Nalini S , Bandgar Tushar R 
Published: August 2020

Introduction:
177Lu-DOTATATE-based peptide receptor radionuclide therapy (PRRT) is a promising therapy for metastatic and/or inoperable pheochromocytoma and paraganglioma (PPGL). We aim to evaluate the efficacy and safety of and identify predictors of response to 177Lu-DOTATATE therapy in metastatic and/or inoperable PPGL.

Methods:
This retrospective study involved 15 patients of metastatic or unresectable PPGL, who received 177Lu-DOTATATE PRRT therapy. Clinical, biochemical (plasma-free normetanephrine), and radiological (anatomical and functional) responses were compared before and after the last therapy.

Results:
A total of 15 patients (4 PCC, 4 sPGL, 5 HNPGL, 1 PCC + sPGL, 1 HNPGL + sPGL) were included. The median duration of follow up was 27 (range: 11–62) months from the start of PRRT. Based on the RECIST (1.1) criteria, progressive disease was seen in three (20%), stable disease in eight (53%), partial response in one (7%), and minor response in three (20%) and controlled disease in 12 (80%). On linear regression analysis the presence of PGL (P= 0.044) and baseline SUVmax >21 (P < 0.0001) were significant positive predictors of early response to PRRT. Encouraging safety profiles were noted with no long term nephrotoxicity and hematotoxicity.

Conclusion:
177Lu-DOTATATE therapy is an effective and safe modality of treatment for patients with metastatic/inoperable PPGL. Although it is not prudent to withhold PRRT in metastatic PPGL with baseline SUVmax < 21, baseline SUVmax >21 can be used to predict early response to PRRT.
A Nested Association Mapping Panel in Arabidopsis thaliana for Mapping and Characterizing Genetic Architecture
Authors: Brock Marcus T , Rubin Matthew J , DellaPenna Dean , Weinig Cynthia 
Published: August 2020

Abstract
Linkage and association mapping populations are crucial public resources that facilitate the characterization of trait genetic architecture in natural and agricultural systems. We define a large nested association mapping panel (NAM) from 14 publicly available recombinant inbred line populations (RILs) of Arabidopsis thaliana, which share a common recurrent parent (Col-0). Using a genotype-by-sequencing approach (GBS), we identified single nucleotide polymorphisms (SNPs; range 563-1525 per population) and subsequently built updated linkage maps in each of the 14 RIL sets. Simulations in individual RIL populations indicate that our GBS markers have improved power to detect small effect QTL and enhanced resolution of QTL support intervals in comparison to original linkage maps. Using these robust linkage maps, we imputed a common set of publicly available parental SNPs into each RIL linkage map, generating overlapping markers across all populations. Though ultimately depending on allele frequencies at causal loci, simulations of the NAM panel suggest that surveying between 4 to 7 of the 14 RIL populations provides high resolution of the genetic architecture of complex traits, relative to a single mapping population.
IDENTIFIKASI SISTEM INSENTIF PENGELOLAAN SUMBERDAYA DI LAGUNA SEGARA ANAKAN
Authors: Suryawati Siti Hajar , Soetarto Endriatmo , Adrianto Luky , Purnomo Agus Heri 
Published: August 2020

Beberapa hasil penelitian menunjukkan bahwa telah terjadi degradasi lingkungan di laguna Segara Anakan Dibutuhkan upaya menahan laju degradasi laguna dan mempersiapkan masyarakat untuk merespon kondisi tersebut. Berbagai ebijakan telah diambil untuk merespon degradasi tersebut seperti pembuatan infrastruktur dan fasilitas dari pemantapan pengelolaan sumberdaya dan program rehabilitasi lingkungan. Terdapat dua kriteria penting untuk memilih suatu implementasi kebijakan dan program, yaitu efektivitas dan efisiensi. Kajian ini mengukur pembiayaan untuk berbagai pilihan kebijakan dengan menggunakan metode survey yang dilaksanakan pada bulan April - May 2010. Kajian ini menggunakan data yang dikumpulkan dari tokoh kunci yang telah ditentukan sesuai tujuan kajian untuk menggambarkan kelompok masyarakat yang memanfaatkan sumberdaya di laguna Segara Anakan. Jumlah total responden adalah 41, yang terdiri dari 25 orang nelayan, 5 orang petani, 5 orang pembudidaya tambak, 2 orang pedagang, dan 2 orang penderes. Sejumlah pertanyaan diajukan untuk mendapatkan informasi tentang jenis insentif, seperti insentif hak kepemilikan, insentif mata pencaharian, insentif pasar, dan insentif fiskal. Hasil kajian menunjukkan bahwa insentif yang tidak langsung seperti pengerukan laguna, budidaya kepiting atau upah untuk yang mau melakukan penanaman mangrove pada lahan tambaknya merepresentasikan pilihan tepat dari pandangan alternatif pengembangan mata pencaharian dari sisi keefektifan pengelolaan lingkungan. Title: Identification of Incentive System of the Resources Management in Segara Anakan Lagoon Several previous research results indicated environmental degradation at the Segara Anakan Lagoon. There is a need to slow down degradation rate of the lagoon and preparing the community to response it. Some policies were implemented to response degradation such as developing infrastructures and facilities and rehabilitation programs. There are two important criteria for setting policies, namely effectiveness and efficiency. This research is to asses costs pertinent to various policy options based on a survey method that was conducted in April- May 2010. This research used data from selected key respondents through purposive sampling to represent clusters of community dwelling at lagoon. Forty-one respondents were selected consisting of 25 fishers, 5 farmers, 5 brackish water pond operators, 2 middlemen, and 2 palm sap tappers. Research questions include information on various kinds of incentives, such as property right incentive, livelihood incentive, market incentive, and fiscal incentive. Research results showed that indirect incentives such as lagoon dredging, crab seedling or salary for those who have willingness to plant mangrove in brackish ponds represented good options from the perspective of alternative livelihood development as well as the effectiveness of environmental management.
STRATEGI PENGELOLAAN SUMBERDAYA PERIKANAN PELAGIS SECARA TERPADU DAN BERKELANJUTAN DI PERAIRAN TELUK TOMINI
Authors: Syahrul Syahrul 
Published: August 2020

Penelitian ini bertujuan untuk melihat potensi, tingkat pemanfaatan, status keberlanjutan sumberdaya perikanan pelagis di Teluk Tomini. Penelitian dilakukan dengan menggunakan metode survei. Pengambilan sampel dilakukan secara cluster random sampling sebanyak 86 orang. Metode analisis data dilakukan secara deskriptif dan kuantitatif. Analisis data yang digunakan yaitu produksi surplus dari Schaefer dan Fox dan analisis keberlanjutan sumber daya perikanan pelagis. Hasil analisis menunjukkan bahwa potensi lestari sumber daya perikanan pelagis di Teluk Tomini sebesar 93.071,21 ton/tahun (model Schaefer) dan 104.044,04 ton/tahun (model Fox) dengan tingkat pemanfaatan tahun 2002-2011 masih di bawah potensi lestari. Dimensi etika, hukum dan regulasi kurang mendukung keberlanjutan sumber daya perikanan pelagis. Peraturan belum memadai dalam pengelolaan terpadu perairan Teluk Tomini. Pengelolaan sumberdaya perikanan pelagis di perairan Teluk Tomini memerlukan pembentukan kawasan terpadu. Title: Strategy of Integrated and Sustainable Pelagic Fishery Resource Management at Tomini Bay The purpose of the study is to observe potention, degree of utilization, status of pelagic fishery resource sustainability at Tomini Bay. The research employs survey method. Sampling is done by random cluster sampling amounted 86 people. Data analysis method uses descriptive and quantitatif method. Data analysis apllies surplus production from Schaefer and Fox, pelagic fishery resource sustainability analysis.Analysis of the study shows that sustainable potention of pelagic fishery resource at Tomini Bay amount 93.071,21 tons/year (Schaefer model), and 104.044,04 tons/year (Fox model) with degree of utilization in2022-2011 is under sustainable potention. Ethical dimension, law and regulation are less supporting the sustainabiliy of pelagic fihsery resource. Regulation in integrated management of Tomini Bay waters isinadequately. It is necessary to establish integrated area of pelagic fishery resource management at Tomini Bay
Bioaccumulation of mercury in clams (Meretrix lyrata) cultured atthe Bach Dang estuary: a recommendation for safe daily dosage consumption of clams in Vietnam
Authors: Sinh Le Xuan , Huong Mai 
Published: August 2020

This study assessed the level of mercury (THg) and methylmercury (MeHg) in seawater and clams (Meretrix lyrata) during all four seasons (July 2010 to May 2011) at the Dong Bai intertidal area in the Bach Dang estuary. The results showed that total mercury and methyl mercuryconcentrations of the water were under the allowable limit. Total mercury and methylmercury concentration for clams ranged from 12.5-87.9 ng/g dw and 1.1-24.6 ng/g dw, respectively. The highest bioaccumulation factor (BAF) of Meretrix lyrata was 303.2 for mercury and 165,000 for methylmercury. The recommended safe dosage for daily clam consumption depends on the season. Over a one-year period, mercury contamination in clams harvested in the Bach Dang estuary ranged from 1.4 to 38.1 g/kg bw. It is not recommended to consume too many clams in March or April.