bluuebunny/crossref_metadata_2025_split huggingface dataset:
Profile of parasuicide cases attending Brits Hospital, North West Province, South Africa: a 5-year chart review
Authors: Bongongo Tombo , Nkuinika K , Nzaumvila DK , Adfolalu A , Okonta H , Govender I , Saidiya CNS 
Published: August 2020

Abstract
Background Parasuicide is referred to as an apparent attempt at suicide without the actual intention of killing oneself. Its prevalence continues to increase in the Brits/Madibeng community. The current study aimed to determine the profile of parasuicide cases attending Brits Hospital, North West Province of South Africa, from 2013 to 2018. Methods The basis of this article is a 5-year retrospective chart review of parasuicide cases attending Brits Hospital from 01 January 2013 to 01 January 2018. Brits Hospital is a 200-bed hospital serving people in the Brits/Madibeng community. Results Of the 477 parasuicide cases, the mean age was 26.6, the median 24 years with minimum and maximum ages respectively of 12 and 64 years. The majority (257; 53.88%) were between 16 and 25 years of age and comprised females (297; 62.26%), African (391; 82.84%), single people (352; 73.79%), unemployed (304; 63.7%) and those who had completed the secondary level of education, 300 (62.9%). The highest number of cases (85, 86 and 87) were registered during the odd years (2013, 2015 and 2017), while the lowest number (68, 75 and 76) during even years, i.e. 2014, 2016 and 2017. The summer months of January and February registered more cases, respectively 65 (13.63%) and 64 (13.42%). The majority of cases (430; 90.15%) represented a first attempt at suicide. Overdose of medication (300; 62.82%) was the most common method used and a relationship problem the main reason that led to the attempt. Most cases (409; 85.74%) did not have any medical or psychiatric symptoms prior to the parasuicide crisis. Conclusion This study painted a clear picture of parasuicidal cases attended at Brits Hospital, being younger between 16-25, mainly female, single, unemployed, the method used for parasuicide mostly overdose of medication and done mainly in Januaries and Februaries. Furthermore, reason for the parasuicidal attempt were relationship problem as well as unemployment. In most of the cases, it was the first attempt.
Systems Biology Unraveled the Relationship of lncRNA OIP5-AS1 with CD25 and its Co-Expression Analysis in Cancers
Authors: Dehbashi Moein , Hojati Zohreh , Motovali-bashi Majid , Cho C. S. , Shimosaka Akihiro , Ganjalikhani-Hakemi Mazdak 
Published: August 2020

Abstract
Background: Treg cells function in the immune homeostasis, these cells express high level of CD25. Even though the molecular mechanisms of CD25-mediated signaling pathways has been reported, some questions are still unclear, e.g. the relationship and function of the relative lncRNA. It is known that the CD25 expression levels are various among different cancers. Thus, we intended to dissect systems biology of a lncRNA pertained to CD25 and CD25 protein interactors-targeting miRNAs. Methods: Apart from using the available RNA-seq data, the co-expression analysis of the lncRNA pertained to some cancers was performed. Our analysis was done for protein interactors of CD25 by STRING 11.0, ShinyGO v0.60 and KEGG web servers were used for enrichment and network analysis of CD25. TargetScan 7.2, miRTargetLink Human and mirDIP were applied for determining the CD25 and CD25 interactors-targeting miRNAs. To find the lncRNA-miRNA and lncRNA-protein interactions, starBase v3.0, LncBase Predicted v.2 and SFPEL-LPI were recruited, respectively. Also, using Co-LncRNA, the co-expressed lncRNA analysis and the relative signaling pathways in some cancers including bladder, breast, head and neck, kidney, liver, lung, prostate and thyroid cancers using RNA-seq data were achieved. Results: OIP5-AS1 was shown to have the interaction with CD25 and CD25 protein interactors-targeting miRNAs. In addition, the co-expression of OIP5-AS1 in cancers and their signaling pathways was identified. Conclusions: Possibly, OIP5-AS1 can effect on CD25 expression in all relative signaling pathways of these cancers.
Verification of virtual reality to evaluate deficiencies in cognitive function among patients with schizophrenia in the remission stage: a cross-sectional study
Authors: Huang Manli , Li Shangda , Sun Bing , Lyu Hailong , Xu Weijuan , Jiao Jianping , Pan Fen , Hu Jianbo , Chen Jinkai , Chen Yaping , Yi Xu 
Published: August 2020

Abstract
Background: Schizophrenia is associated with widespread cognitive impairments. The MATRICS Consensus Cognitive Battery (MCCB) is most frequently used to assess cognitive function. However, the MCCB test can be time consuming for the clinician. Virtual reality (VR) has emerged as an adjunctive tool to overcome this limitation, which provides a new means of assessing cognitive function. Methods: The study is to explore the validity and safety of using VR technology to assess cognitive function in Han Chinese patients with schizophrenia. The virtual reality supermarket training system (VRSTS), which simulates real-life supermarkets, was used to assess cognitive function. Thirty-two patients with schizophrenia (SZs) and 25 healthy controls (HCs) received the VRSTS and MCCB assessments. A diagnosis model was created based on the outcomes of VRSTS to classify SZs and HCs by cognitive impairment. Results: Significant differences in completion time between the SZs and HCs were detected on the VRSTS. SZs spent more time completing tasks than HCs. The outcome of VRSTS was significantly correlated with the MCCB. Moreover, the diagnosis model has a sensitivity of 88.89% and a specificity of 88.89%. Conclusions: These results provide support for VR technology in the assessment of cognitive impairment in schizophrenia among Han Chinese patients.Trial registration: China Clinical Trial Registry, ChiVTR1800016121. Registered 13 May 2018, http://www.chictr.org.cn/showproj.aspx?proj=27233
The subchronic toxic effects of Mosla Chinensis Maxim in normal rats.
Authors: Lei Dan , Li Longxue , Huang Shenghong , Liu Li , Cai Pingdong , Gu Zhouyang , Shu Kun , Li Shouming , Liu Zhiyong 
Published: August 2020

Abstract
Background: The aim of this work was to study the toxic effects and target organs of Mosla Chinensis Maxim (MCM) in rats and provide theoretical basis for clinical medication.Methods: The subchronic toxicity study was conducted on 60 male and female SD rats using the fixed-dose method for the treatment group and 20 male and female SD rats for the control. At the subchronic toxicity study, the water extract of MCM with fixed-dose of 0.2g/kg/day, 2g/kg/day and 20g/kg/day was administered for 90 days intragastric, and the control group was given the same amount of distilled water. After 90 days, the general conditions of the rats were observed. Assesment on safety of the extract was conducted by a subchronic toxicity test which mainly examined alteration occured in gut flora and urine metabolism. Results: The results showed that there were no significant toxic effects observed at all doses on physical sign and reactivity and fecal property of rats in the treatment groups had no obvious difference from those in control group. The results of routine blood test showed that the number of red blood cells in the male medium dose group and the female low dose group were significantly different from those in the control group (P<0.05). The results of serum biochemical indicators test showed that MCM had influence on the indicators of liver and kidney function, but it had no toxicological significance. In terms of glucose and lipid metabolism, the LDL level of male rats was lower than that of the control group (P<0.05). Compared with the control group, GLU level of female rats in the low, medium and high dose groups was significantly increased (P<0.05), indicating that long-term administration of MCM would affect the glucose level of female rats. The results of intestinal flora diversity showed that feeding MCM for 90 days had an impact on the distribution of intestinal flora. The content of lactobacillus increased and the ratio of Firmicutes and Bacteroidetes (F/B) was also affected, but there was no significant difference. Conclusions: These findings showed that the long-term intragastric administration of the MCM is safe to use within its dose recommendation. But it could have slight affect the metabolism of uric acid by changing the composition of intestinal flora and affecting the metabolism of tryptophan.
A Quantitative Discriminant Method of Elbow Point for the Optimal Number of Clusters in Clustering Algorithm
Authors: Shi Congming , Wei Bingtao , Wei Shoulin , Wang Wen , Liu Hai , Liu Jialei 
Published: August 2020

Abstract
Clustering, as a traditional machine learning method, is still playing a significant role in data analysis. The most of clustering algorithms depend on a predetermined exact number of clusters, whereas, in practice, clusters are usually unpredictable. Although elbow method is one of the most commonly used methods to discriminate the optimal cluster number, the discriminant of the number of clusters depends on manual identification of the elbow points on the visualization curve, which will lead to the experienced analysts not being able to clearly identify the elbow point from the plotted curve when the plotted curve being fairly smooth. To solve this problem, a new elbow point discriminant method is proposed to work out a statistical metric estimating an optimal cluster number when clustering on a dataset. Firstly, the average degree of distortion obtained by Elbow method is normalized to the range of 0 to10; Secondly, the normalized results are used to calculate Cosine of intersection angles between elbow points; Thirdly, the above calculated Cosine of intersection angles and Arccosine theorem are used to compute the intersection angles between elbow points; Finally, the index of the above computed minimal intersection angles between elbow points is used as the estimated potential optimal cluster number. The experimental results based on simulated datasets and a public well-known dataset demonstrated that the estimated optimal cluster number output by our newly proposed method is better than widely used Silhouette method.
Hidden Pulmonary Arteries in Tetralogy of Fallot and Pulmonary Artery Pressure in Patients Operated with a Pulmonary Artery
Authors: Edraki Mohammadreza , Ghasemzadeh Bahram , Keshavarz Kambiz , Amirghofran Ahmadali , Mohammadi Hamid , Kheirandish Zahra , Amoozgar Hamid , Ajami Gholamhossein , Mehdizadegan Nima , Naghshzan Amir , Peiravian Farah , Cheriki Sirous , Nobahkti Mohammadjavad 
Published: August 2020

Abstract
Introduction: The absence of a pulmonary artery is a rare congenital anomaly that occurs on its own or with some congenital cardiac disorders, particularly tetralogy of Fallot (TOF), while the hidden pulmonary artery might originate from a closed ductus arteriosus (DA) that can be stented to reach the artery.Material and methods: This prospective study describes cardiac catheterization of our nine TOF patients who had the absence of the left pulmonary artery before the operation. The patients were stratified in three groups: group one, whose closed DA were found and stented successfully to the hidden pulmonary artery; group two, whose hidden pulmonary arteries were found via the pulmonary vein angiography; and group three, for whom we could not find the remnant of the DA, or our attempt to stent the DA to the hidden pulmonary artery was not successful.We also evaluated outcomes of the other surgically-corrected TOF patients who were operated with the absent left pulmonary artery.Results: The first group included patients aged 1, 24, and 30 months, whose CT angiography 6-9 months after stenting showed acceptable left pulmonary artery diameter for surgically correction, while the pulmonary vein angiography of the group two patients showed a hidden left pulmonary artery with a suitable diameter for surgical correction.However, we were unable to find or stent the DA of the group three patients, aged 12, 38, 60, and 63 months. Moreover, evaluation of the other six previously corrected patients who were operated with a right pulmonary artery revealed pulmonary artery hypertension of the entire patients.Conclusion: The concealed pulmonary artery might be found, and stenting of the closed DA to it might be performed to improve the diameter of the diminutive pulmonary artery. This procedure may allow TOF total surgical correction with two pulmonary arteries. Besides, pulmonary vein angiography can reveal the hidden pulmonary artery.
Impact of Cardiac Function Improvement on Cardiac Surgery Associated Acute Kidney Injury for Patients with Preoperative Renal Dysfunction
Authors: Xu Jiarui , Chen Xin , Lin Jing , Li Yang , Shen Bo , Jiang Wuhua , Luo Zhe , Wang Chunsheng , Ding Xiaoqiang , Teng1 Jie , Lv Wenlv 
Published: August 2020

Abstract
Background: We aim to investigate whether the postoperative cardiac function improve or not would affect the risk of cardiac surgery associated acute kidney injury (AKI) for patients with preoperative renal dysfunction. Method: Data from patients underwent cardiac surgery from April 2012 to February 2016 were collected. Renal dysfunction was defined as preoperative SCr >1.2 mg/dL (females) or >1.5 mg/dL (males). Patients were grouped as normal renal function group, renal dysfunction with chronic kidney disease (CKD group), and non CKD group. △LVEF=postoperative LVEF - preoperative LVEF. Cardiac function improved was defined as △LVEF ≥10. Patients were further divided into non CKD & cardiac function improved (non CKD+), non CKD & cardiac function not improved (non CKD-), CKD & cardiac function improved (CKD+) and CKD & cardiac function not improved (CKD-) subgroups.Results: A total of 8,661 patients were allocated as normal renal function (n=7,903), non CKD(n = 662) and CKD (n = 136) groups. Both non CKD and CKD groups had higher AKI incidence than normal function group (39.5% vs 30.0%, P < 0.001; 61.8% vs 30.0%, P<0.001), and non CKD+ group had the similar AKI incidence with normal function group (30.9% vs 30.0%, P=0.729). Multivariate logistic regression analysis revealed that non CKD-, CKD+ and CKD- were significant risk factors, whereas non CKD+ was not a significant risk factor for postoperative AKI. The SCr at discharge in non CKD+ subgroup was significantly lower than its preoperative SCr (1.4 ± 0.8 vs 1.7 ± 0.9 mg/dL, P = 0.020).Conclusions: For renal dysfunction patients with no CKD, the risk of postoperative AKI did not exist if the cardiac function improved after surgery. For CKD patients, the risk of postoperative AKI increase regardless whether the cardiac function improved or not.
IgG4-Related Disease as Mimicker of Malignancy
Authors: Zhou WanLi , Murray Timothy , Cartagena Liliana , Lim Howard , Schaeffer David F. , Slack Graham W. , Skinnider Brian F. , Lam Eric , Irvine Robert , Chung Stephen , Mattman Andre , Chang Silvia , Carruthers Mollie N. , Chen Luke Y.C. 
Published: August 2020

Abstract
Background: IgG4-related disease is an immune-mediated disease that may present as a tumefactive lesion in nearly any organ. These mass lesions often resemble malignancy both clinically and radiologically, and some patients undergo unnecessary surgical resection. We performed a retrospective single center study examining how many patients with IgG4-RD were initially believed to havemalignancy,with particular attention to those who underwent potentially avoidable surgical procedures. Methods: 63 patients with biopsy confirmed IgG4-Related Disease based on International Consensus Criteria were included. Clinical, laboratory, radiological and histological data were collected and analyzed.Results: Over 60% of patients (38/63) were initially thought to have a malignancywhen they initially presented with symptomatic IgG4-RD. The most common types of malignancy suspected were lymphoma (18/38) and pancreatic cancer (11/38). Of the 38 patients with suspected malignancy, 14 underwent an invasive intervention either to alleviate the severity of their symptoms or as treatment for their presumed malignancy.These included Whipple resection/attempted Whipple (3), nephrectomy (3), bile duct resection and reconstruction (1), removal of other abdominal/retroperitoneal masses (3), and stenting of obstructed organs (4).Conclusion: IgG4-RD should be on the differential diagnosis of patients with mass lesions, in particular those with pancreatic masses and obstructive jaundice, extensive lymphadenopathy, or retroperitoneal masses. Oncologists and other physicians involved in cancer care should be aware of the various manifestations and diagnostic approach to IgG4-RD in order to provide accurate diagnosis and minimize unnecessary invasive procedures.
Land use management and carrying capacity of Bangsri Micro Watershed, East Java, Indonesia: a baseline study
Authors: Dwiastuti Rini , Setiawan Nuri Nurlaila , Aprilia Anisa , Laili Fitrotul , Setyowati Putri Budi 
Published: August 2020

Abstract
The increase of unsustainable human activities in watershed areas gave a huge pressure, causing land degradation and reduced the river water quality. This study aimed to describe the land use management and calculate the carrying capacity as a part of natural resource management of Bangsri Micro Watershed, the upper Brantas watershed in East Java, Indonesia. Data was gathered from five villages through interviews, questionnaires, and focus group discussions with multiple stakeholders. In addition, data from the local government statistics bureau (i.e., Statistics Indonesia) was also used. From the total 2,765 ha land area, eight different land use were identified with agroforestry (970 ha) being the largest and bare land (43 ha) being the smallest. There were 17 crop patterns with 10 different commodities recorded. Based on the present land use, the total land monetary value (biocapacity) was 298 billion Indonesian Rupiah (IDR) or equal to 27,278 tonnes of rice production. From the total population of 27,645; the total annual income (i.e., ecological footprint based on the minimum wage and real household income) needed is 577-854 billion IDR (72,101-106,771 tonnes of rice), thus considered as a deficit carrying capacity value. An urgent watershed management planning is needed to reduce the environmental pressure while ensuring the fulfilment needs of the people in Bangsri Micro Watershed.
Exploration the mechanism of doxorubicin-induced Heart failure in Rats by integration of proteomics and metabolomics data
Authors: Yuan Yu , Fan Simiao , Shu Lexin , Huang Wei , Xie Lijuan , Bi Chenghao , Yu Hongxin , Wang Yuming , Li Yubo 
Published: August 2020

Abstract
Background

Heart failure is currently a worldwide systemic disease with high morbidity and mortality and is very common. At present, many studies have shown that heart failure is associated with obesity, hypertension and diabetes, but it is still unable to prevent the disease from progressing. Here, we elucidate the molecular mechanisms of doxorubicin–induced harmful effects on rat cardiac metabolism and function from a new perspective, using metabonomics and Proteomics analysis data.
Methods

The aim of this study was to use metabonomic and proteomic techniques to systematically elucidate the molecular mechanisms of doxorubicin (DOX)–induced heart failure (HF) in rat. In this study, we aimed to systematically elucidate the molecular action of Dox on rats heart and the reasons for DOX–induced the HF mechanism through the metabonomics tandem mass tag (TMT)–based quantitative proteomics approach. Rats were gavaged with DOX (3 mg/kg) for 6 weeks and the plasma metabonomics, cardiac tissue proteomics, histopathology and related proteins expression levels.
Results

A total of 278 proteins and 21 metabolites were significantly altered in rats following DOX treatments. The responsive proteins and metabolites were predominantly involved in Fatty acid metabolism, Glycolysis, glycerophospholipid metabolism, TCA cycle, Glutathione metabolism, Myocardial contraction.
Conclusions

The present study indicates the PTP1B inhibits the expression of HIF-1α by inhibiting the phosphorylation of IRS, leading to disorders of fatty acid metabolism and glycolysis, which together with the decrease of Nrf2, SOD, Cytc and AK4 proteins lead to oxidative stress, suggesting the PTP1B may serve as a potential target in the treatment of heart failure.
Renalase levels and genetic variants are associated with preeclampsia: a hospital based study in Chinese cohort
Authors: Li Xianshu , Huang Qianqian , Xu Jing 
Published: August 2020

Abstract
Background

Pre-eclampsia (PE) is a major contributor of maternal and fetal morbidity and mortality. There are many host related biomolecules that regulate the pathophysiology PE. Critical analysis of these parameters is of crucial importance as some of these may be used as prognostic/diagnostic marker of this serious ailment and can be targeted for developing therapeutic measures against the disease. The aim of the current study is to examine the role of renalse in the context PE in a Chinese cohort.
Methods

A hospital based case control study was designed to investigate role of renalase in PE. 384 Chinese women consisting of subjects with normotensive pregnancy (n = 105), women with PE (n = 121) and healthy pregnancy (n = 158) were included in the study. Serum renalse level was measured in recruited subjects by ELISA. Renalase gene polymorphisms (rs10887800, rs2576178 and rs2296545) were genotyped by PCR-RFLP.
Results

A higher level of serum renalse in healthy pregnant women compared to controls, whereas, subjects with PE demonstrated a reduced level of this enzyme. Renalse level was negatively correlated with systolic as well as diastolic blood pressure, whereas, a positive association was observed with glomerular filtration rate. Prevalence of homozygous mutant (GG) and minor allele (G) of rs10887800 and rs2576178 polymorphisms were higher in PE patients compared to normotensive pregnant women and healthy controls. Furthermore, association of G-G-C haplotype with susceptibility to PE was observed.
Conclusions

Low level of renalse may be associated with high risk of PE during pregnancy. Renalase gene polymorphisms (rs10887800 and rs2576178) are correlated with with serum renalase and associated with predisposition to development of PE in Chinese cohort.