bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of short-course antibiotics on the antimicrobial resistance profile of colonizing gut bacteria in the ICU
Authors: Munck Christian , Sheth Ravi , Cuaresma Edward , Stump Stephania , Weidler Jessica , Zachariah Philip , Chong David , Uhlemann Anne-Catrin , Abrams Julian , Wang Harris , Freedberg Daniel E 
Published: November 2019

Abstract
Background: The need for early antibiotics in the intensive care unit (ICU) is often balanced against the goal of antibiotic stewardship. We sought to determine how short-course antibiotics in the ICU affect the antimicrobial resistance phenotype and genotype of colonizing gut bacteria. Results: Deep rectal swabs were performed on 48 adults at the time of ICU admission and 72 hours later, including patients who did and did not receive antibiotics. To determine resistance phenotype, rectal swabs were cultured for MRSA and VRE; in addition, Gram-negative isolates were cultured against relevant antibiotics. To determine resistance genotype, quantitative PCR was performed for 87 established resistance genes. Within-individual changes in antimicrobial resistance were calculated based on culture and qPCR results and correlated with exposure to relevant antibiotics (e.g., β-lactam exposure and changes in β-lactam resistance). Of 48 ICU patients, 41 (85%) received antibiotics. Overall, there was no increase in the antimicrobial resistance profile of colonizing gut bacteria during the 72 hour study period. There was also no increase in antimicrobial resistance after stratification by receipt of antibiotics (i.e., no increase in β-lactam, vancomycin, or macrolide resistance regardless of whether patients received those same antibiotics). This was true for both culture and PCR. Antimicrobial resistance pattern at ICU admission strongly predicted resistance pattern after 72 hours. Conclusions. Short-course ICU antibiotics made little difference in the antimicrobial resistance pattern of colonizing gut bacteria over 72 hours in the ICU. This provides improved understanding of the dynamics of antimicrobial resistance in the ICU and some reassurance that short-course antibiotics may not adversely impact the stewardship goal of reducing antimicrobial resistance.
Circular RNA SMARCA5 correlates with favorable clinical tumor features and prognosis, and increases chemotherapy sensitivity in intrahepatic cholangiocarcinoma
Authors: Qi Lu , Tao Fang 
Published: November 2019

Abstract
Background This present study aimed to investigate the correlation of circular RNA SMARCA5 (circ-SMARCA5) with clinicopathological features and overall survival (OS), and the effect of circ-SMARCA5 on cell proliferation and chemotherapy sensitivity to cisplatin/gemcitabine in intrahepatic cholangiocarcinoma (ICC).Methods Totally 92 primary ICC patients who underwent resection were recruited, and their tumor tissues, adjacent tissues were collected for circ-SMARCA5 detection. The effect of circ-SMARCA5 on cell proliferation and chemotherapy sensitivity was detected after circ-SMARCA5 overexpression plasmids transfection into TFK-1 and HuH-28 ICC cells.Results Circ-SMARCA5 expression was reduced in ICC tumor tissues compared to adjacent tissues. Tumor circ-SMARCA5 high expression was negatively associated with Eastern Cooperative Oncology Group performance score, T stage, N stage, TNM stage and abnormal CA199 status. Furthermore, OS was increased in patients with tumor circ-SMARCA5 high expression compared with those with low expression, and further multivariate Cox’s regression demonstrated that tumor circ-SMARCA5 high expression was an independent predictive factor for longer OS. In TFK-1 and HuH-28 ICC cells, circ-SMARCA5 upregulation decreased cell proliferation, reduced relative cell viability in cisplatin-treated as well as gemcitabine-treated cells, and also decreased inhibitory concentration by 50% value (IC50) of cisplatin and gemcitabine.Conclusions The correlation of circ-SMARCA5 with favorable clinical tumor features, survival profile, and its promoting effect on chemotherapy sensitivity imply its potential as a valuable biomarker in monitoring disease progression and prognosis of ICC.
Number of children and the prevalence of later-life major depression and insomnia in women and men: findings from a cross-sectional study of 0.5 million Chinese adults.
Authors: Wang Hanyu , Chen Minne , Xin Tong , Tang Kun 
Published: November 2019

Abstract
Pregnancy and parenthood have been associated with physical and mental health. Previous literature concerning the impacts of parity on mental health was inconsistent and lack epidemiolocal evidence. China, with growing mental health problems and changing fertility patterns, faces unique challenges. This study aims to examine the relationship between parity and the prevalence of major depression and insomnia among men and women in the Chinese population. Methods Baseline data from a Chinese population-based study of 512,891 adults (59.01% women) from 10 areas, aged 30-79 were analyzed. Number of children were based on self-report by the participants. Major depression (MD) was assessed using the Composite International Diagnostic Inventory. Insomnia symptoms were accessed by questionnaire comparable to that used in Diagnostic and Statistical Manual of Mental Disorders. Logistic regression was used to assess the relationship between MD/Insomnia and number of children, after stratifications and adjustments. Results For women, each additional child was associated with a 9% decreased odds of MD (OR: 0.91, 95%CI: 0.88-0.96), with the associations significant for those who lived in urban areas (OR: 0.76, 95%CI: 0.70-0.83), or had a lower education (OR: 0.90, 95%CI: 0.85-0.94), or had lower household income (OR: 0.89, 95%CI: 0.85-0.94), or had ever used alcohol (OR: 0.89, 95%CI: 0.84-0.93). The association between per additional children and MD was not significant in men (OR: 1.02, 95%CI: 0.97-1.07) but a decreased odds of MD with per additional child was found in men who lived in urban areas (OR: 0.81, 95%CI: 0.71-0.96). For women, each additional child was associated with a 4% decreased odds of insomnia (OR: 0.96, 95%CI: 0.95-0.96). Each additional child was also associated with a 2% decreased odds of insomnia in men (OR: 0.98, 95%CI: 0.97-1.00). Conclusions MD and insomnia was associated with number of children, particularly in women and the association was mediated by socioeconomic and lifestyle factors. Future mental health public health programs should address parity and sex differences when designing interventions.
The trends in global, regional, and national incidence of pneumoconiosis caused by different etiologies: an analysis from the Global Burden of Disease Study 2017
Authors: Shi Peng , Xing Xiaoyue , Xi Shuhua , Jing Hongmei , Yuan Jiamei , Fu Zhushan , Zhao Hanqing 
Published: November 2019

Abstract
Pneumoconiosis has the potential to cause progressive and permanent physical disability. And continues to be one of major public health concern across the world. However, our literature searches identified a scarcity of data about global prevalence of pneumoconiosis. Accurate data on the incidence of pneumoconiosis is critical for health resource planning and health policy development. We therefore aimed to determine the pattern of pneumoconiosis incidence and temporal trends. Methods: Annual incident cases and age standardized incidence rates on pneumoconiosis etiology between 1990-2017 were collected from the Global Burden of Disease Study 2017. We calculate the average annual percentage changes of age standardized incidence rates by sex, region, and etiology to determine incidence trends of pneumoconiosis. Results: Globally, the number of pneumoconiosis cases increased 66.0% from 36,186 in 1990 to 60,055 in 2017. The overall age standardized incidence rate decreased by an average 0.6% (95% CI: 0.5%, 0.6%) per year in the same period. The age standardized incidence rate of silicosis, asbestosis, and other pneumoconiosis decreased between 1990 and 2017. The corresponding average annual percentage changes were -0.8%, -0.9%, and -0.5%, respectively. The age standardized incidence rate of asbestosis displayed an increasing trend. At the same time, we also found a significant negative association was found between average annual percentage changes and socio-demographic indexs when the socio-demographic index above 0.7. Conclusions: Pneumoconiosis remains a major occupational health illnesses in the world. Incidence patterns of pneumoconiosis caused by different etiologies were heterogeneous across regions and countries. We observed an unfavorable trend that asbestosis was predominant in countries with a high socio-demographic index, though we have attained great achievements in silicosis and coal workers’ pneumoconiosis prevention. The information in this study suggests that some countries should establish more targeted and specific strategies to forestall the increase in pneumoconiosis.
CYP3A4 and CYP11A1 Variants are Risk Factors for Ischemic Stroke: a Case Control Study
Authors: Gao Ning , Tang Hong , Gao Ling , Tu Guolong , Luo Han , Xia Ying 
Published: November 2019

Abstract
Background This study aimed to investigate the roles of CYP3A4 and CYP11A1 variants in ischemic stroke (IS) susceptibility among the Han Chinese population. Methods 477 patients with IS and 493 healthy controls were enrolled. Seven single-nucleotide polymorphisms (SNPs) of CYP3A4 and CYP11A1 were genotyped by Agena MassARRAY. Odds ratio (OR) and 95% confidence intervals (CI) were calculated by logistic regression adjusted for age and gender. Results We found that CYP3A4 rs3735451 (OR = 0.81, p = 0.039) and rs4646440 (OR = 0.72, p = 0.021) polymorphisms decreased the risk of IS. CYP3A4 rs4646440 (OR = 0.74, p = 0.038) and CYP11A1 rs12912592 (OR = 1.58, p = 0.034) polymorphisms were correlated with IS risk in males. CYP3A4 rs3735451 (OR = 0.63, p = 0.031) and rs4646440 (OR = 0.57, p = 0.012) possibly weaken the IS susceptibility at age > 61 years. Besides, CYP3A4 rs4646437 (OR = 0.59, p = 0.029), CYP11A1 rs12912592 (OR = 1.84, p = 0.017) and rs28681535 (OR = 0.66, p = 0.038) were associated with IS risk at age ≤ 61 years. CYP11A1 rs28681535 TT genotype was higher high-density lipoprotein cholesterol level than the GT and GG genotype (p = 0.027). Conclusions Our findings indicated that rs3735451, rs4646440, rs4646437 in CYP3A4 and rs28681535 in CYP11A1 might be protective factors for IS, while CYP11A1 rs12912592 polymorphism be a risk factor for IS in Chinese Han population.
Nano-soldiers Ameliorate Silibinin Delivery: A Review Study
Authors: Ashrafizadeh Milad , Ahmadi Zahra , Mohammadinejad Reza , Farkhondeh Tahereh , Samarghandian Saeed 
Published: November 2019

:Flavonoids are a large group of naturally occurring compounds, which are of interest due to their great pharmacological effects and health-promoting impacts. These properties have led to their extensive application in a variety of pathological conditions, particularly cancer. Flavonoids are used in large quantities in a human's daily diet and a high amount of flavonoids are found in the intestine after oral usage. However, flavonoid concentrations in tissue/plasma are low because of their low bioavailability, the leading to the low efficacy of flavonoids in different clinical disorders. For this reason, nanotechnology application for delivering flavonoids to tumor sites has recently received significant attention. Silibinin is a key member of flavonoids and a bioactive component of silymarin, which is widely isolated from Silybum marianum. This plant-derived chemical has a number of valuable biological and therapeutic activities such as antioxidant, anti-inflammatory, neuroprotective, anti-tumor, hepatoprotective, cardioprotective and anti-diabetic. These beneficial effects have been demonstrated in in vivo and in vitro experiments. However, it seems that silibinin has a variety of limitations and poor bioavailability is the most important factor restricting its wide application. Hence, there have been attempts to improve the bioavailability of silibinin and it has been suggested that nano-soldiers are potential candidates for this aim. In the present review, we describe the different drug delivery systems for improving the bioavailability of silibinin.
Tingkat kesiapan Perpustakaan Universitas Gadjah Mada dalam penerapan summon discovery service
Authors: Isthuufia Ulfaa 
Published: November 2019

Introduction. The information retrieval service continues to experience growth form of a card catalog into a computer-based catalog (OPAC), and became discovery. The purpose of this study to determine the level of readiness of UGM Library in the application of summon discovery service.Data Collection Method. This paper used survey with a quantitative approach. Analysis Data. The data was analyzed by statistical descriptive and hypothesis testing using SPSS software.Results and Discussions. The results showed of the organizational readiness of 2.55, which categorized “ready”The level of readiness of organizational resources obtained the score 2.54 and categorised “ready”.Conclusions.. In the variable organization, the highest indicator was organizational culture followed by the organizational structure and management support. In terms of organization Resources, human resources were the highest followed by ICT, and financial resources.
THE IMPROVING STUDENTS’ INTEREST BY USING PUPPET MEDIA at SMALB-C TUTWURI HANDAYANI CIMAHI
Authors: Ardiah Vina Ilmi Na'fiul , Andrianty Astry 
Published: November 2019

Education is the main thing for children to gain knowledge in school. In learning English, children with special needs has difficulty in learning. From this analysis, the writers do some research on children who have special needs to creasing their interest, enterprising and easy in learning English at SMALB-C Tutuwuri Handayani Cimahi. Researcher hope, in this research is able to remind people’s awarness and the government to children with special needs in providing education. Because, they have the same rights in education. The reseacher was conducted entitle “The Improving Students’ Interest by Using Puppet Media”. This research, the use puppet media as one of the tools teaching to increase students’ interest and improve their vocabulary in learning English. The use of puppet as media with technique matching the puppet with the word. The reseacher took in class X and XI, in class X there are 2 students and class XI there are 3 students, so we combine there are 5 students. This study used an oral test, obervation checklist and interview for collecting data. Researcher have found the results of the research and observations of the students. The result of the students 75% improve their interst, improved their writing 65 %, improved their speaking 60%, improve their vocabulary and speech 65%, recognize matching puppet process 70%, participate in class 35%. From the observation above, the researcher is conviced that the use of puppet as one of media can increase the students’ interest and vocabulary in learning English.
USING SONG TO IMPROVE VOCABULARY MASTERY FOR ELEMENTARY SCHOOL
Authors: Ramadini Amelia , Halimah Siti 
Published: November 2019

The purpose of this reseach is to know how the use song to improve the students’ vocabulary mastery in learning English for elementary school students. The population of this research is SD Lebak Gede it consist thirty student. To analyzed the data the research using SPSS versi 17.0. The test of normality is feris step to know the data is normality distributed. Kolmogorov-smirnov test was used in this research, it can be seen the significant of Kolmogorov-smirnov from pretest was 0.36 and posttest was 0.30 is higher than 0.50. It means that the data is normality distributed. The t-observed of pretest is 21.921 and t-observed of posttest was 56.550. The degree of freedom (df) 29 is 1.691. It means that t-observed of this research is higher than the t-table. The significance (2-tailed) of the data was 0.000 is lower than 0.05. It menas that the data of pretest and posttest is significant. Minimum score pretest was 30 and the maximum score pretest was 80, and the minimum score of posttest was 70 and maximum of posttest was 100. The mean of pretest score 54.60 and the mean of posttest was 81.07. The standard deviation of pretest was 13.642 and standar deviation of posttest was 7.852. It means, the data was improvement. Found that teaching vocabulary mastery using song for elementary school is effective. Keywords: Teaching Vocabulary, Using Song
COMPARING SNOWBALL THROWING TECHNIQUE WITH SCIENTIFIC APPROACH IN IMPROVING SPEAKING SKILL
Authors: Wardani Bestari Retno , Rachman Aulia , Satriani Intan 
Published: November 2019

This research purpose is to analyse the capability of students’ speaking improvement through Snowball Throwing Technique. The research method applied in this research is quantitative method with a quasi-experimental design. This research had been conducted at SMP Wiyata Bakti Cimahi. The sample for this research took 30 students from each class, that is class 8C selected become the experiment class that used Snowball Throwing Technique and class 8A selected become the control class that used the Scientific Approach. The research result concluded that: (1) the students’ speaking capability through Snowball Throwing Technique is better than Scientific Approach and (2) the students’ speaking capability improvement through Snowball Throwing Technique is better than Scientific Approach.Keywords: Speaking, Snowball Throwing Technique, Scientific Approach, Quasi-experiment
IMPROVING STUDENTS' READING COMPREHENSION OF RECOUNT TEXT BY USING THINK-PAIR-SHARE (TPS) TECHNIQUE
Authors: Vidya Radhita , Nuraini Annisa 
Published: November 2019

The aims of this research is to improve reading comprehension of the eighth-grade students using think-pair-share technique. The researchers applying this technique is to make students actively learn in classthrough pair discussions and sharing information with their friends. The researchers used a classroom action research (CAR) method, this research has been carried out in three cycles to achieve students improvement in reading comprehension. The mean scores of students in the first cycle is 57.60, in the second cycle is 64.67, and in the third cycle is 77.20. The mean scores of the three cycles prove that the think-pair-share technique has succeeded in improving students' reading comprehension of recount text. Keywords: Think-Pair-Share, Reading comprehension ,Recount text.
THE USE OF CONJUNCTION: ELABORATION IN DONALD TRUMP’S SPEECH
Authors: Setimaji Febru , Abdulah Teguh , Haryudin Acep 
Published: November 2019

Abstract Speaking is kind of communication that human needs to give same understanding of mind and works. The term of ‘speech’ has meaning to give some explanation from speaker to audience with many intention from the speaker based on their speech. The speech of Donald Trump at his first state on the january 2018 giving some explanation about the condition in USA today. This research giving the information about the use of conjunction: elaboration in Donald trump speech. The research goal to give some explanation about the types of conjunction and the meaning inside of it. This research used qualitative with the method have been used by the writers is textual analysis method as supported by Frey, et al. The analysis of data show us the precentage of subtype of conjunction: elaboration that Donald trump’s use at his speech are Expository 60%, Exemplifying 8%, Corrective 8%, Particularizing 8%, Resumptive 8%, Verifactive 8%. Donald Trump used appositive so often rather than using clarification on his speech. It means he is less doing clarification to have understanding between him and the audience
NUMBERED-HEAD TOGETHER IN TEACHING READING NARRATIVE
Authors: Ramadhanty Anisa , Ruyani Yayan , Syahrizal Trisnendri 
Published: November 2019

Reading comprehension is needed by students in order to have a good reading skill. In this journal, the researchers are trying to examine the implementation of NHT technique in improving students’ reading comprehension of narrative text. Quantitative used as the research method with pre-experimental research design. There are three stages in conducting pre-experimental design. First, students are given pre-test to measure their knowledge. Second, students are given the treatment and last, students are given posttest after using NHT technique. In conducting the data, the researchers spend seven times consisted of pretest, posttest, and five times treatments. As the result, the mean score of pre-test is 43.58. After implementing NHT technique in every meeting, reading comprehension of students had been getting better, it can be seen in average of the mean score of post-test became 62.45. It can be concluded that NHT technique can improve students’ reading comprehension.Keywords: Numbered-head together, Students’ reading comprehension
(Retracted) The Development of Learning Resources to Avoid Violence Acts on Children
Authors: Gunadi Andi Ahmad 
Published: November 2019

Violence in children is a physical act of aggression by parents who can cause trauma and even bring death to children. Purpose of research: 1. knowing the appropriate role of parenting; 2. knowing the acts of violence on children; 3. knowing the source of learning to avoid acts of violence on children. Research method used qualitative description, data collection: observation and interview in the form of discussion. The result of research: Parenting role consists of authoritarian, democratic, authoritative, and permissive. Violence occurs in children in the form of physical, psychological, and economic violence. Learning resources that can be utilized in an effort to avoid acts of violence in children can be made based on material elements or messages, people, and materials.
Application and Evaluation of Performance Quality of Hose-Reel Irrigation Machine
Authors: Jobbágy Ján , Michlian Norbert , Dačanin Peter , Rigó Ivan 
Published: November 2019

Abstract
Considering the global tendency in water saving, this research is focused on practical measurements of even distribution of water. The performance quality is determined by values of coefficients of distribution uniformity and non-uniformity given in percentages. Objects of investigation were belt irrigators with varying input conditions (seven pieces). Testing of hose-reel irrigators took place in Southern and Western Slovakia. Tests were carried out during irrigation of selected agricultural crops (potatoes, vegetables); in these areas, rainwater vessels were distributed at a spacing of 1 or 2 m, perpendicular to the direction of movement of the bracket or tripod with a gun sprinkler. The input conditions, such as machine specifications and weather conditions, were monitored and evaluated for all variants. The data were also analysed along with the linear model through statistical analysis software – one-way analysis of variance ANOVA. Considering the results, it is possible to conclude that there were recorded statistically significant differences for uniformity coefficients, depending not only on the site but also on the specific evaluation methodology (P > 0.05). If the input conditions (site, type of irrigator, sprinkler) were changed, the effect of dependence was demonstrated to a much greater extent (P <0.05, F = 7.08> Fcrit
). The results of the non-uniformity coefficients confirmed the statistically significant differences not only in the sample sets of coefficients but also in the selection sets of conditions.