bluuebunny/crossref_metadata_2025_split huggingface dataset:
RETRACTED: Promotion of cell autophagy and apoptosis in cervical cancer by inhibition of long noncoding RNA LINC00511 via transcription factor RXRA‐regulated PLD1
Authors: Shi Yangyang , Liu Mengran , Huang Yan , Zhang Jing , Yin Ling 
Published: February 2020

AbstractAn increasing number of studies have explored the relationship of long noncoding RNAs (lncRNAs) with cervical cancer, yet the role of LINC00511 in cervical cancer still remains elusive. The current dissertation was intended to explore the effect of LINC00511 on cervical cancer development by regulating phospholipase D1 (PLD1) expression through transcription factor retinoic X receptor alpha (RXRA). Differentially expressed lncRNA and messenger RNA related to cervical cancer were screened by microarray‐based expression profiling. Cervical cancer and paracancerous tissues were harvested to determine the LINC00511 expression using reverse transcription‐quantitative polymerase chain reaction and western blot analysis. The relationship among LINC00511, PLD1 promoter activity, and RXRA were determined via RNA immunoprecipitation, chromatin immunoprecipitation, and dual‐luciferase reporter assays. Proliferation, autophagy, and apoptosis of cervical cancer cells were detected with a series of experiments. Tumor xenograft in nude mice was employed to determine the influence of LINC00511 and PLD1 on tumor formation and growth of cervical cancer in vivo. LINC00511 might influence the occurrence of cervical cancer by upregulating PLD1 expression via recruiting transcription factor RXRA. LINC00511 and PLD1 expressions were remarkably high in cervical cancer tissues and cells. LINC00511 combined with RXRA, and overexpression of LINC00511 in cervical cancer cells elevated PLD1 expression. Si‐LINC00511, si‐RXRA or si‐PLD1 triggered repression of proliferation and promotion of autophagy and apoptosis of cervical cancer cells. In vivo experiment, si‐LINC00511, or si‐PLD1 inhibited the tumorigenic ability of nude mice. Collectively, this study suggests that LINC00511 acts as an oncogenic lncRNA in cervical cancer via the promotion of transcription factor RXRA‐regulated PLD1.
Upregulated lncRNA UCA1 inhibits trophoblast cell invasion and proliferation by downregulating JAK2
Authors: Liu Jie , Luo Chengyan , Zhang Chu , Cai Qian , Lin Jihui , Zhu Tong , Huang Xiaojie 
Published: February 2020

AbstractNumerous studies have suggested that urothelial cancer‐associated 1 (UCA1) acts as a suppressor gene affecting cell proliferation and migration. However, the biological role and the potential mechanism of UCA1 in the progression of pre‐eclampsia (PE) remains unclear. The UCA1 level was markedly upregulated in PE pregnancies relative to non‐PE ones in GSE75010 and tissues. A higher body mass index (BMI), maximum systolic blood pressure (BP), and maximum diastolic BP were observed in PE pregnancies, whereas the newborn weight z‐score was lower compared with those of non‐PE pregnancies. Knockdown of UCA1 accelerated the proliferative migratory abilities and cell cycle progression, but inhibited apoptosis of HTR‐8/SVneo and JAR cells. Then, we found that Janus kinases 2 (JAK2) was negatively correlated with UCA1. In addition, JAK2 was downregulated in the placenta of PE pregnancies and was negatively regulated by UCA1. UCA1 was mainly enriched in the nucleus. Knockdown of UCA1 reduced the occupancies of the enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) and H3K27me3 on the Janus kinase 2 (JAK2) promoter regions. Finally, rescue experiments found that transfection of short‐hairpin JAK2 attenuated proliferative and migratory abilities of trophoblasts, which were partially reversed after UCA1 knockdown. In short, UCA1 is upregulated in the trophocytes of PE pregnancies and accelerates trophoblast cell invasion and proliferation by downregulating JAK2.
Resolving the mystery—How TCR transgenic mouse models shed light on the elusive case of gamma delta T cells
Authors: Hahn Anne M. , Winkler Thomas H. 
Published: February 2020

Abstract
Cutting-edge questions in αβ T cell biology were addressed by investigating a range of different genetically modified mouse models. In comparison, the γδ T cell field lacks behind on the availability of such models. Nevertheless, transgenic mouse models proved useful for the investigation of γδ T cell biology and their stepwise development in the thymus. In general, animal models and especially mouse models give access to a wide range of opportunities of modulating γδ T cells, which is unachievable in human beings. Because of their complex biology and specific tissue tropism, it is especially challenging to investigate γδ T cells in in vitro experiments since they might not reliably reflect their behavior and phenotype under physiologic conditions. This review aims to provide a comprehensive historical overview about how different transgenic mouse models contributed in regards of the understanding of γδ T cell biology, whereby a special focus is set on studies including the elusive role of the γδTCR. Furthermore, evolutionary and translational remarks are discussed under the aspect of future implications for the field. The ultimate full understanding of γδ T cells will pave the way for their usage as a powerful new tool in immunotherapy.
Synthesis of a Multifunctional Quinoxaline and Benzodithiophene Bearing Polymer and Its Electrochromic Device Applications
Authors: Yasa Mustafa , Surmeli Seher , Depci Tolga , Toppare Levent , Hacioglu Serife Ozdemir 
Published: February 2020

AbstractA quinoxaline (Qx) and benzodithiophene (BDT) comprising of random copolymers, namely poly(5‐(6‐(5‐(4,8‐bis((2‐ethylhexyl)oxy)benzo[1,2‐b:4,5‐b′]dithiophen‐2‐yl)‐4‐(2‐ethylhexyl)thiophen‐2‐yl)‐4,8‐bis ((2‐ethylhexyl)oxy)benzo[1,2‐b:4,5‐b′]dithiophen‐2‐yl)‐2,3‐bis(3,4‐bis(octyloxy)phenyl)quinoxaline) (PQBT), is synthesized via Stille polycondensation reaction. To investigate the effect of the π‐bridge on the electrochromic properties, 3‐(2‐ethylhexyl) thiophene is incorporated the between Qx and BDT moiety. The resulting random copolymer is characterized by NMR spectroscopy, gel permeation chromatography (GPC), attenuated total reflectance−Fourier‐transform infrared spectroscopy (ATR−FTIR), and scanning electron microscopy (SEM). PQBT exhibits ambipolar and multichromic characteristics and is highly soluble in common solvents. Optoelectronic studies reveal two well‐separated absorption bands having maxima at 500 and 532 nm with 1.83 eV optical band gap (Egop). PQBT exhibits orange color in the neutral state with brown, green, and blue colors in the intermediate, oxidized, and reduced states, respectively. Subsequently, a PQBT and poly‐3,4‐ethylenedioxythiophene (PEDOT)‐bearing prototype bilayer electrochromic device working between orange and blue colors is constructed and characterized.
Does ketamine ameliorate the social stress‐related bladder dysfunction in mice?
Authors: Yang Stephen Shei‐Dei , Chang Hsi‐Hsien , Chang Shang‐Jen 
Published: February 2020

AbstractAimsThe aim of this study is to investigate whether ketamine could relieve the social stress (SS)‐related bladder dysfunction in mice.Materials and MethodsThe FVB mice were randomly assigned to either undergo SS exposure for 60 minutes per day on seven consecutive days for 4 weeks (SS1) or control without SS (SS0). The SS0 were then allocated to single or no injection of ketamine (SS0K1 and SS0K0). In the group of SS1, the SS1 mice were allocated to receive single injection of saline (SS1K0), single dose (SS1K1) or five daily dose of (SS1K5) ketamine injection (25 mg/kg/day/ip) since day 22. In vivo cystometry and tissue bath wire myography were performed on day 29. Serum and urine level of brain‐derived neurotrophic factor (BDNF) were measured with enzyme‐linked immunosorbent assay.ResultsIn mice without social stress exposure, ketamine administration did not significantly affect voiding frequency (P > .05). SS1K0, SS1K1, and SS1K5 had significantly lower voiding frequency than that of control (SS1K0) (each n = 15, P < .05). Ketamine administration reversed the trend of decreased voiding frequency in SS1 mice. Stressed mice had significant higher serum level of BDNF that reduced by short‐term ketamine. Stressed mice had detrusor overactivity and impaired detrusor contractility which were not reversed by short‐term ketamine.ConclusionsSocial stress leads to elevated serum BDNF, infrequent voiding, detrusor overactivity, and impaired contractility. Short‐term administration of ketamine may improve SS‐related infrequent voiding and elevated serum BDNF level. However, ketamine did not improve SS‐related bladder dysfunction on urodynamic and myography studies.
A sequential partial information bomber‐defender shooting problem
Authors: Kalyanam Krishna , Casbeer David , Pachter Meir 
Published: February 2020

AbstractA bomber carrying homogenous weapons sequentially engages ground targets capable of retaliation. Upon reaching a target, the bomber may fire a weapon at it. If the target survives the direct fire, it can either return fire or choose to hold fire (play dead). If the former occurs, the bomber is immediately made aware that the target is alive. If no return fire is seen, the true status of the target is unknown to the bomber. After the current engagement, the bomber, if still alive, can either re‐engage the same target or move on to the next target in the sequence. The bomber seeks to maximize the expected cumulative damage it can inflict on the targets. We solve the perfect and partial information problems, where a target always fires back and sometimes fires back respectively using stochastic dynamic programming. The perfect information scenario yields an appealing threshold based bombing policy. Indeed, the marginal future reward is the threshold at which the control policy switches and furthermore, the threshold is monotonic decreasing with the number of weapons left with the bomber and monotonic nondecreasing with the number of targets left in the mission. For the partial information scenario, we show via a counterexample that the marginal future reward is not the threshold at which the control switches. In light of the negative result, we provide an appealing threshold based heuristic instead. Finally, we address the partial information game, where the target can choose to fire back and establish the Nash equilibrium strategies for a representative two target scenario.
Exploring the educational needs of nurses on children’s pain management: A descriptive qualitative study
Authors: Kusi Amponsah Abigail , Kyei‐Dompim Joana , Bam Victoria , Kyei Evans F. , Oduro Evans , Ahoto Collins K. , Axelin Anna 
Published: February 2020

AbstractAimTo explore the educational needs of nurses on children's pain management.DesignA descriptive qualitative study.MethodsIndividual and group interviews were conducted among 28 nurses and four nurse managers at four hospitals in the Ashanti region of Ghana. The recorded interviews were later transcribed verbatim and thematically analysed based on a conceptual interest in the educational needs on paediatric pain management.ResultsNurses were acquainted with pain assessment of children who can verbally communicate. They mainly used drugs in treating pain and were familiar with the use of some non‐pharmacological interventions. Notwithstanding, they desired to know more about pain assessment for children with non‐functional speech. Additionally, they were interested in learning more about both drug and nondrug pain relief methods for children. The sampled nurses and nurse managers indicated diverse preferences on the nature of the paediatric pain educational programme based on their personal choices and working dynamics.
Translating claims‐based CHA2DS2‐VaSc and HAS‐BLED to ICD‐10‐CM: Impacts of mapping strategies
Authors: Webster‐Clark Michael , Huang Ting‐Ying , Hou Laura , Toh Sengwee 
Published: February 2020

AbstractPurposeThe CHA2DS2‐VaSc and HAS‐BLED risk scores are commonly used in the studies of oral anticoagulants (OACs). The best ways to map these scores to the International Classification of Diseases, 10th Revision, Clinical Modification (ICD‐10‐CM) codes is unclear, as is how they perform in various types of OAC users. We aimed to assess the distributions of CHA2DS2‐VaSc and HAS‐BLED scores and C‐statistics for outcome prediction in the ICD‐10‐CM era using different mapping strategies.MethodsWe compared the distributions of CHA2DS2‐VaSc and HAS‐BLED scores from various mapping strategies in atrial fibrillation patients before, during, and after ICD‐10‐CM transition. We estimated the C‐statistics predicting the 90‐day risk of hospitalized stroke (for CHA2DS2‐VaSc) or hospitalized bleeding (for HAS‐BLED) in patients identified at least 6 months after the ICD‐10‐CM transition, overall and by anticoagulant type.ResultsForward‐backward mapping produced higher CHA2DS2‐VaSc and HAS‐BLED scores in the ICD‐10‐CM era compared to the ICD‐9‐CM era: the mean difference was 0.074 (95% confidence interval 0.064‐0.085) for CHA2DS2‐VaSc and 0.055 (0.048‐0.062) for HAS‐BLED. Both scores had higher C‐statistics in patients taking no OACs (0.697 [0.677‐0.717] for CHA2DS2‐VaSc; 0.719 [0.702‐0.737] for HAS‐BLED) or direct OACs (0.695 [0.654‐0.735] for CHA2DS2‐VaSc; 0.700 [0.673‐0.728] for HAS‐BLED) than those taking warfarin (0.655 [0.613‐0.697] for CHA2DS2‐VaSc; 0.663 [0.6320.695] for HAS‐BLED).ConclusionsExisting mapping strategies generally preserved the distributions of CHA2DS2‐VaSc and HAS‐BLED scores after ICD‐10‐CM transition. Both scores performed better in patients on no OACs or direct OACs than patients on warfarin.
The Aging Metabolome—Biomarkers to Hub Metabolites
Authors: Sharma Rishi , Ramanathan Arvind 
Published: February 2020

AbstractAging biology is intimately associated with dysregulated metabolism, which is one of the hallmarks of aging. Aging‐related pathways such as mTOR and AMPK, which are major targets of anti‐aging interventions including rapamcyin, metformin, and exercise, either directly regulate or intersect with metabolic pathways. In this review, numerous candidate bio‐markers of aging that have emerged using metabolomics are outlined. Metabolomics studies also reveal that not all metabolites are created equally. A set of core “hub” metabolites are emerging as central mediators of aging. The hub metabolites reviewed here are nicotinamide adenine dinucleotide, reduced nicotinamide dinucleotide phosphate, α‐ketoglutarate, and β‐hydroxybutyrate. These “hub” metabolites have signaling and epigenetic roles along with their canonical roles as co‐factors or intermediates of carbon metabolism. Together these hub metabolites suggest a central role of the TCA cycle in signaling and metabolic dysregulation associated with aging.
Design and development of self‐repairable and recyclable crosslinked poly(thiourethane‐urethane) via enhanced aliphatic disulfide chemistry
Authors: Liu Qing , Liu Yibin , Zheng Hua , Li Chunmei , Zhang Yi , Zhang Qiuyu 
Published: February 2020

AbstractThermoset polymer elastomers that are capable of autonomous repairability upon physical damage at ambient temperature are highly desirable because of their thermal and environmental resistance, outstanding mechanical toughness and stability. To aim at this goal, we demonstrated that tris(diethylamino)phosphine was initially proven as an efficient catalyst for the aliphatic disulfide exchange at mild condition. By making use of the aliphatic disulfide bond reshuffling and elasticity of polyurethane elastomers, the inherently cross‐linked polysulfide‐based poly(thiourethane‐urethane) elastomers were prepared and exhibited the ability to mend without extrinsic stimuli in the presence of phosphorus catalyst at room temperature after artificially damaged. The self‐healing efficiency via the mechanical recovery approach was investigated to be mainly dependent upon the cross‐linking density of polysulfide and hard segments chemistry, which in turns determined the molecular chain diffusion and reshuffling that was corroborated by the stress‐relaxation study. The thermoset elastomer based on asymmetric diisocynate showed a maximum self‐healing efficiency of 85.6% compared to 71.6% for the elastomer with symmetric monomer building blocks. The self‐healable polymer was confirmed to be recyclable and reprocessable through a cut‐compression processing cycle under a quite mild pressure and temperature thanks to the disulfide bond reshuffling. Meanwhile, the recycled thermoset elastomer well maintained the mechanical properties to its original material.
A variable parameters multivariate control chart for simultaneous monitoring of the process mean and variability with measurement errors
Authors: Sabahno Hamed , Castagliola Philippe , Amiri Amirhossein 
Published: February 2020

AbstractEvaluating the effect of measurement errors on either adaptive or simultaneous control charts has been a topic of interest for the researchers in the recent years. Nevertheless, the effect of measurement errors on both adaptive and simultaneous monitoring control charts has not been considered yet. In this paper, through extensive numerical studies, we evaluate the effect of measurement errors on an adaptive (variable parameters) simultaneous multivariate control chart for the mean vector and the variance‐covariance matrix of p quality characteristics assumed to follow a multivariate normal distribution. In order to do so, (a) we use eight performance measures computed using a Markov chain model, (b) we consider the effects of multiple measurements as well as the error model's parameters, and (c) we also consider the overall performance of this adaptive simultaneous chart including the chart parameters values optimization, which have never been considered so far for this scheme. At last, a real case is presented in order to illustrate the proposed scheme.
Time‐lapse monitoring of mouse embryos produced by injecting sonicated, frozen‐thawed sperm heads with high or low chromosomal integrity
Authors: Harada Yoshihisa , Kinutani Masayuki , Horiuchi Toshitaka 
Published: February 2020

AbstractPurposeTo investigate the first‐division kinetics and in vitro development of embryos produced by injecting sonicated sperm heads with high or low chromosomal integrity into oocytes.MethodsMouse spermatozoa were frozen after separating the sperm heads from the tails by sonication in an EGTA solution (EGTA group) or M2 medium (M2 group). The chromosomal integrity of sonicated mouse spermatozoa was analyzed by injecting the sperm heads into fresh mouse oocytes. The developmental potential of spermatozoa was examined by injecting the sperm heads into vitrified‐warming mouse oocytes. We used a time‐lapse monitoring system to compare the first‐division kinetics.ResultsChromosomal integrity was preserved significantly more frequently in the EGTA group (90.6%) than in the M2 group (32.7%). Blastocysts developed significantly more often in the EGTA group (80.8%) than in the M2 group (39.6%). In the M2 group, with frequent chromosome aberrations, the time between the sperm injection and first cleavage was delayed (18.4 hours), compared to the EGTA group (16.5 hours). All results of the EGTA group were similar to that of fresh epididymal spermatozoa.ConclusionThe EGTA solution for sonication maintained the integrity of sperm chromosomes. Our results revealed a relationship between sperm chromosome integrity and first‐division kinetics.
State estimation for linear hybrid systems with periodic jumps and unknown inputs
Authors: Ríos Héctor , Dávila Jorge , Teel Andrew R. 
Published: February 2020

SummaryIn order to solve the state estimation problem for linear hybrid systems with periodic jumps and unknown inputs, some hybrid observers are proposed. The proposed observers admit a Luenberger‐like structure and the synthesis is given in terms of linear matrix inequalities (LMIs). Therefore, the proposed observer designs are completely constructive and provide some input‐to‐state stability properties with respect to unknown inputs. It is worth mentioning that the structure of the hybrid observers, as well as the structure of the LMIs, depends on some observability properties of the flow and jump dynamics, respectively. Then, in order to compensate the effect of the unknown inputs, a hybrid sliding‐mode observer is added to the Luenberger‐like observer structure, providing exponential convergence to zero of the state estimation error despite certain class of unknown inputs. The existence of the hybrid observers and the unknown input hybrid observer is guaranteed if and only if the hybrid system is observable and strongly observable, respectively. Some numerical examples illustrate the feasibility of the proposed estimation approach.
A Heterostructure Coupling of Bioinspired, Adhesive Polydopamine, and Porous Prussian Blue Nanocubics as Cathode for High‐Performance Sodium‐Ion Battery
Authors: Liu Yang , He Dandan , Cheng Yingjie , Li Lin , Lu Zhansheng , Liang Rui , Fan Yangyang , Qiao Yun , Chou Shulei 
Published: February 2020

AbstractPrussian blue (PB) and its analogues are recognized as promising cathodes for rechargeable batteries intended for application in low‐cost and large‐scale electric energy storage. With respect to PB cathodes, however, their intrinsic crystal regularity, vacancies, and coordinated water will lead to low specific capacity and poor rate performance, impeding their application. Herein, nanocubic porous NaxFeFe(CN)6 coated with polydopamine (PDA) as a coupling layer to improve its electrochemical performance is reported, inspired by the excellent adhesive property of PDA. As a cathode for sodium‐ion batteries, the NaxFeFe(CN)6 electrode coupled with PDA delivers a reversible capacity of 93.8 mA h g−1 after 500 cycles at 0.2 A g−1, and a discharge capacity of 72.6 mA h g−1 at 5.0 A g−1. The sodium storage mechanism of this NaxFeFe(CN)6 coupled with PDA is revealed via in situ Raman spectroscopy. The first‐principles computational results indicate that FeII sites in PB prefer to couple with the robust PDA layer to stabilize the PB structure. Moreover, the sodium‐ion migration in the PB structure is enhanced after coating with PDA, thus improving the sodium storage properties. Both experiments and computational simulations present guidelines for the rational design of nanomaterials as electrodes for energy storage devices.
In Situ Growth of CoP3/Carbon Polyhedron/CoO/NF Nanoarrays as Binder‐Free Anode for Lithium‐Ion Batteries with Enhanced Specific Capacity
Authors: Du Yingjie , Ma Wei , Li Haibo 
Published: February 2020

AbstractAdvanced functional materials enable lithium‐ion batteries to reach high specific capacity. To achieve this goal, nickel foam (NF), as current collector, is chosen to in situ form aligned nanoarrays composed of CoP3/carbon polyhedron (CP)/CoO. The CoO nanowire acts as bridge to link NF and CoP3/CP which not only reinforces the adhesion between active material and NF but also enhances the capacity of whole electrode. Besides, CoP3 is evenly coupled with CP, which can effectively buffer the volume expansion of CoP3 during the charge/discharge process. Moreover, the novel architecture of CoP3/CP/CoO/NF is beneficial to improve the electronic conductivity. As a result, the CoP3/CP/CoO/NF anode delivers an ultrahigh specific capacity of 1715 mAh g−1 at 0.5 A g−1 which can remain at 1150 mAh g−1 after 80 cycles, demonstrating the good durability. Thus, this work develops a facile strategy to design self‐supporting electrodes for an enhanced energy storage device.