bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiences and perceptions of referrals to a community-based physical activity program from cancer survivors: A qualitative exploration
Authors: Faro Jamie M , Mattocks Kristin M , Mourao Dalton , Nagawa Catherine S , Lemon Stephenie C , Wang Bo , Cutrona Sarah L , Sadasivam Rajani S 
Published: December 2020

Abstract
Background
Physical activity rates in cancer survivors continue to be low despite the known benefits and availability of evidence-based programs. LIVESTRONG at the Y is a national community-based physical activity program offered cost-free to cancer survivors, though is underutilized. We explored perceptions and experiences of staff and participating survivors to better understand program awareness, referrals and participation.
Methods
LIVESTRONG at the Y program staff [directors (n = 16), instructors (n = 4)] and survivors (n = 8) from 8 United States YMCAs took part in 30-minute semi-structured phone interviews. Interviews were digitally recorded, transcribed, and evaluated using a thematic analysis approach.
Results and Discussion
Program staff themes included: 1) Program awareness should be further developed for both the general public and medical providers; 2) Strong relationships with medical providers increased program referrals; 3) Electronic referral systems between providers and LIVESTRONG would help to streamline the referral process; and 4) Bi-directional communication between program staff and medical providers is key to providing patient progress updates. Survivor themes included: 1) Survivors trust their medical team and the information they provide about physical activity; 2) Providers need to incorporate an action plan and referrals for survivors to be active once treatments are completed; and 3) Personal experiences of those who participated in LIVESTRONG resonate with survivors and increase participation.
Conclusions
LIVESTRONG staff reported the need for an integrated electronic referral system and bi-directional communication with providers about participant progress. Survivors want physical activity education, electronic referrals and follow-up from their healthcare team, coupled with peer support from other survivors. Cancer care provider knowledge and electronic referrals during and after treatment may expedite and increase participation in this community-based program.
Newborn Screening for Inherited Metabolic Diseases Using Tandem Mass Spectrometry in China: outcome and cost-utility analysis
Authors: Zhao Zixuan , Chen Chi , Sun Xueshan , ZHOU Duo , Huang Xinwen , Dong Hengjin 
Published: December 2020

Abstract
BackgroundFew studies in China have focused on economic evaluation of newborn screening(NBS) for inherited metabolic diseases (IMDs) by tandem mass spectrometry (MS/MS). This study assessed the total costs, benefits, benefit-cost ratio(BCR), cost-utility ratio(CUR) and incremental cost-utility ratio(ICUR) of NBS using MS/MS compared to non-screening group for the first time.MethodsThis study was conducted as a retrospective piece. Newborns who underwent MS/MS screening for IMDs from 2009 to 2018 were included. All records were extracted from a screening management system in NBS Center of Zhejiang province. All costs, including indirect cost, were discounted at a rate of 5% for the whole life-time. The putative benefit of clinical outcomes related to early-diagnosis through screening was assumed as improvements in quality of life and potential life expectancy in screening group.ResultsOf the 3,040,815 newborns screened, 26,297(0.86%) newborns were suspected positive after first-round screening and called back to take another MS/MS screening. 25,670(97.62%) of them followed the latter procedures and finally 735(2.86%) cases were diagnosed through gene sequence analysis. The most frequent cause of IMD was amino acid diseases(n=276), in most cases fatty acid oxidation disorders (n=248), followed by organic acidemias (n=211). The difference of QALYs ranged from 0.78-15.4. The CUR was CNY¥86,155.80/QALY in screening group and CNY¥303,9517.32/QALY in non-screening group. The ICUR was CNY¥-795,686.47/QALY, and the BCR was 1:8.11.ConclusionsNBS using MS/MS can be considered as cost-effective. Nationwide promotion of NBS using MS/MS deserves priority consideration and sufficient publicity.
Novel Wideband Circularly Polarized DRA With Squint-free Radiation Characteristics
Authors: Abedian Mohammad , Khalily Mohsen , Singh Vikrant , Xiao Pei , Tafazolli Rahim , Kishk Ahmed 
Published: December 2020

Abstract
A new single-fed circularly polarized dielectric resonator antenna (CP-DRA) without beam squint is presented. The DRA comprises of an S-shaped dielectric resonator (SDR) with a metalized edge and two rectangular dielectric resonator (RDRs) blocks. A horizontal-section is applied as an extension of the SDR, and a vertical-section is placed in parallel to the metallic edge. A vertical coaxial probe is used to excite the SDR and the vertical RDR blocks through an S-shaped metal element and a small rectangular metal strip, respectively. The two added RDRs that form an L-shaped DR improve the radiation characteristics and compensate for the beam squint errors. A wideband CP performance is achieved due to the excitation of several orthogonal modes such as TEx d11, TEy 1d1, TEz 121, TEy 112, TEx 131, and TEy 311. The experimental results demonstrate an impedance bandwidth of approximately 66:8% (3:71-7:45 GHz) and a 3-dB axial-ratio (AR) bandwidth of about 54:8% (3:72-6:53 GHz) with a stable broadside beam achieving a measured peak gain of about 4:64dBi. Furthermore, a 100% correction in beam squint value from q = 41° to q = 0° with respect to the antenna boresight is achieved.
MiR-96-5p relieves neuropathic pain by targeting ZEB1
Authors: Wang Fang , Wang Li 
Published: December 2020

Abstract
BackgroundMicroRNAs (miRNAs) gradually attracts researchers’ attention in regulating the development of neuropathic pain, and many miRNAs have been reported that were able to alleviate neuropathic pain. Meantime, neuroinflammations promote the process of neuropathic pain. MiR‐96‐5p was associated with many pathological diseases, including many kinds of cancers. However, we knew little about the biological function of miR‐96‐5p in the regulation of neuropathic pain development. Hence, we focused our study on the biological function of miR‐96‐5p in neuropathic pain.ResultsAs the result, a decrease of miR‐96‐5p expression was observed in CCI rats model. Meanwhile, the overexpression of miR-96-5p resulted in inhibition of inflammation‐correlated biomarkers of IL‐6, IL‐1β and Cox-2. In addition, we predicted the zinc finger E‐box binding homeobox 1 (ZEB1) was one target of miR‐96‐5p, with a conserved interaction site at 3′‐untranslated region of ZEB1. Furthermore, we observed the increased expression of ZEB1 in CCI rats at both of transcriptional and translational level and miR‐96‐5p could regulate that negatively. And overexpressing ZEB1 would disrupt the miR-96-5p inducing alleviation of neuropathic pain, along with IL‐6, IL‐1β and Cox-2 up-regulated. ConclusionsOur study demonstrated that miR‐96‐5p could relieve neuropathic pain by targeting ZEB1 in vivo.
MiR-4448&nbsp;Is Involved in Deltamethrin Resistance by Targeting CYP4H31&nbsp;in Culex Pipiens Pallens
Authors: Li Xixi , Hu Shengli , Yin Haitao , Zhang Hongbo , Zhou Dan , Sun Yan , Ma Lei , Shen Bo , Zhu Changliang 
Published: December 2020

Abstract
Background: Mosquitoes are vectors of serious diseases affecting human health. Unfortunately, mosquitoes have developed deltamethrin resistance because of its long-term overuse, representing a major challenge to mosquito control. Understanding the molecular regulatory mechanisms of resistance is vital to control mosquitoes. MicroRNAs (miRNAs) are short non‑coding RNAs that have been demonstrated as important regulators of gene expression across a wide variety of organisms, which might function in mosquito deltamethrin resistance. Methods: In the present study, we used quantitative real-time reverse transcription PCR to measure miR-4448 and CYP4H31 (encoding a cytochrome P450) expression levels. The regulatory functions of miR-4448 and CYP4H31 were assessed using Dual-Luciferase reporter assays. Then, oral feeding, RNA interference, and the American Centers for Disease Control and Prevention bottle bioassay were used to determine miR‑4448’s association with deltamethrin resistance by targeting CYP4H31 in vivo. A Cell Counting Kit-8 (CCK-8) was also used to detect the viability of pIB/V5-His-CYP4H31-transfected C6/36 cells after deltamethrin treatment in vitro. Results: MiR-4448 was downregulated in the deltamethrin-resistant strain (DR-strain), whereas CYP4H31 was downregulated in deltamethrin-susceptible strain. negatively regulated CYP4H31 expression was downregulated by miR-4448 recognizing and binding to its 3' untranslated region. Functional verification experiments showed that miR-4448 overexpression resulted in lower expression of CYP4H31. The mortality of miR-4448 mimic-injected DR-strain mosquitoes was higher than that of the controls. CCK-8 assays showed that CYP4H31 decreased cellular resistance to deltamethrin in vitro and the mortality of the DR-strain increased when CYP4H31 was knocked down CYP4H31 in vivo. Conclusions: In mosquitoes, miR-4448 participates in deltamethrin resistance by targeting CYP4H31. The results of the present study increase our understanding of deltamethrin resistance mechanisms.
White Matter Hyperintensities in Autopsy-Confirmed Frontotemporal Lobar Degeneration and Alzheimer's Disease
Authors: Desmarais Philippe , Gao Andrew , Keith Julia , Lanctôt Krista , Rogaeva Ekaterina , Ramirez Joel , Herrmann Nathan , Stuss Donald T. , Black Sandra E. , Masellis Mario 
Published: December 2020

Abstract
BackgroundWe aimed to systematically describe the burden and distribution of white matter hyperintensities (WMH) and investigate correlations with neuropsychiatric symptoms in pathologically proven Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD).MethodsAutopsy-confirmed cases were identified from the Sunnybrook Dementia Study, including 15 cases of AD and 58 cases of FTLD (22 FTLD-TDP cases; 10 FTLD-Tau [Pick's] cases; 11 FTLD-Tau Corticobasal Degeneration cases; and 15 FTLD-Tau Progressive Supranuclear Palsy cases). Data analyses included ANCOVA to compare the burden of WMH on antemortem brain MRI between groups and adjusted linear regression models to identify associations between WMH burden and neuropsychiatric symptoms. ResultsBurden and regional distribution of WMH differed significantly between neuropathological groups (F5,77 = 2.67, P’ = 0.029), with the FTLD-TDP group having the highest mean volume globally (8,031.50 ± 8,889.15 mm3) and in frontal regions (4,897.45 ± 6,163.22 mm3). The AD group had the highest mean volume in occipital regions (468.25 ± 420.04 mm3). Total score on the Neuropsychiatric Inventory correlated with bilateral frontal WMH volume (β = 0.330, P = 0.006), depression correlated with bilateral occipital WMH volume (β = 0.401, P < 0.001), and apathy correlated with bilateral frontal WMH volume (β = 0.311, P = 0.009), all corrected for the false discovery rate. ConclusionsThese findings suggest that WMH are associated with neuropsychiatric manifestations in AD and FTLD and that WMH burden and regional distribution in neurodegenerative disorders differ according to the underlying neuropathological processes.
Baseline Cognition Is the Best Predictor of 4-year Cognitive Change in Cognitively Intact Older Adults
Authors: Schaeverbeke Jolien , Gabel Silvy , Luckett Emma , Meersmans Karen , De Meyer Steffi , Adamczuk Katarzyna , Nelissen Natalie , Goovaerts Valerie , Radwan Ahmed , Sunaert Stefan , Dupont Patrick , Laere Koen Van , Vandenberghe Rik 
Published: December 2020

Abstract
BackgroundWe examined in cognitively intact older adults the relative weight of cognitive, genetic, structural and amyloid brain imaging variables for predicting cognitive change over a 4-year time course. MethodsHundred-eighty community-recruited cognitively intact older adults (mean age 68 years, range 52-80 years, 81 women) belonging to the Flemish Prevent Alzheimer's Disease KU Leuven (F-PACK) longitudinal observational cohort underwent a baseline evaluation consisting of detailed cognitive assessment, structural MRI and 18F-flutemetamol PET. At inclusion, subjects were stratified based on Apolipoprotein E (APOE) epsilon4 and Brain Derived Neurotrophic Factor (BDNF) val66met polymorphism according to a factorial design. At inclusion, 15% were amyloid PET positive (Centiloid > 23.4). All subjects underwent 2-yearly follow-up of cognitive performance for a 4-year time period. Baseline cognitive scores were analysed using factor analysis. The slope of cognitive change over time was modelled using latent growth curve analysis. Using correlation analysis, hierarchical regression and mediation analysis, we examined the effect of demographic (age, sex, education) and genetic variables, baseline cognition, MRI volumetric (both voxelwise and region-based) as well as amyloid imaging measures on the longitudinal slope of cognitive change. ResultsA base model of age and sex explained 18% of variance in episodic memory decline. This increased to 41.6\% by adding baseline episodic memory scores. Adding amyloid load or volumetric measures explained only a negligible additional amount of variance (increase to 42.2%). A mediation analysis indicated that the effect of age on episodic memory scores was partly direct and partly mediated via hippocampal volume. Amyloid load did not play a significant role as mediator between age, hippocampal volume and episodic memory decline. ConclusionIn cognitively intact older adults, the strongest baseline predictor of subsequent episodic memory decline was the baseline episodic memory score. When this score was included, only very limited explanatory power was added by brain volume or amyloid load measures. The data warn against classifications that are purely biomarker-based and highlight the value of baseline cognitive performance levels in predictive models.
A Smartphone Ocular Alignment Measurement App in School Screening for Strabismus
Authors: Cheng Wenbo , Lynn Marissa H. , Pundlik Shrinivas , Almeida Cheryl , Luo Gang , Houston Kevin 
Published: December 2020

Abstract
Background: Strabismus is the leading risk factor for amblyopia, which should be early detected for minimized visual impairment. However, traditional school screening for strabismus can be challenged due to several factors, most notably training, mobility and cost. The purpose of our study is to evaluate the feasibility of using a smartphone application in school vision screening for detection of strabismus.Methods: The beta smartphone application, EyeTurn, can measure ocular misalignment by computerized Hirschberg test. The application was used by a school nurse in a routine vision screening for 133 elementary school children. All app measurements were reviewed by an ophthalmologist to assess the rate of successful measurement and were flagged for in-person verification with prism alternating cover test (PACT) using a 2.4Δ threshold (root mean squared error of the app). A receiver operating characteristic (ROC) curve was used to determine the best sensitivity and specificity for an 8Δ threshold (recommended by AAPOS) with the PACT measurement as ground truth.Results: The nurse obtained at least one successful app measurement for 93% of children (125/133). 40 were flagged for PACT, of which 6 were confirmed to have strabismus, including 4 exotropia (10△, 10△, 14△ and 18△), 1 constant esotropia (25△) and 1 accommodative esotropia (14△). Based on the ROC curve, the optimum threshold for the app to detect strabismus was determined to be 3.0△, with the best sensitivity (83.0%), specificity (76.5%). With this threshold the app would have missed one child with accommodative esotriopia, whereas conventional screening missed 3 cases of intermittent extropia.Conclusions: Results support feasibility of use of the app by personnel without professional training in routine school screenings to improve detection of strabismus.
Effect of 150 kHz Electromagnetic Radiation on the Development of Polycystic Ovaries Induced by Estradiol Valerate in Sprague Dawley Rats.
Authors: Mohammed Stephanie , Sundaram Venkatesan , Zyuzikov Nikolay 
Published: December 2020

Abstract
Background: Polycystic ovary syndrome (PCOS) is the most common complex endocrine disorder affecting approximately 2-20% of reproductive aged females. Tumour Treating Fields (100-300 kHz) is a recent innovative, non-invasive therapeutic approach to cancer therapy. This frequency as an alternative therapy for the management of polycystic ovaries has not yet been explored.Objectives: To explore the effect of full-body exposure of 150 kHz Electromagnetic Radiation (EMR), on the development of polycystic ovaries in an estradiol valerate-induced PCOs rats’ model.Method: Twenty-one female adult rats were divided into three groups (n=7 each): control, Estradiol Valerate (EV) and EV + EMR groups. The EV + EMR group was subjected to full body exposure at 150 kHz EMR continuously for eight consecutive weeks. Estradiol valerate was administered orally to induce polycystic ovaries in EV and EV+EMR groups. Body and ovarian weights were recorded and analysed. The regularity of the estrous cycle was assessed in all three groups. The histological study of ovarian tissue was carried out by haematoxylin and eosin staining. The serum concentration levels of Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH) and testosterone were measured using the ELISA method.Results: The body and ovary weights did not differ significantly between the EV and EV + EMR groups. The estrous cycle was found to be irregular in both the EV and EV + EMR groups. Ovarian histology revealed near normal morphology with little or no degenerative and morphological changes in developing follicles in the exposed group. Histometrical analysis showed an increased number of developing follicles and a significant reduction in the number and size of follicular cysts (p < 0.05) in the EV+EMR group. Hormonal analysis revealed no significant difference in the testosterone and FSH levels between the EV+EMR and EV groups. However, the LH, LH/FSH ratio decreased significantly in the EV+EMR group compares to the EV group.Conclusion: The 150 kHz EMR appear to have little or no degenerative and morphological changes in the developing follicles, an increased number of typical developing follicles and a significant reduction in the number and size of the follicular cysts (p < 0.05).Subject Classification codes: Electromagnetic Radiation, Polycystic Ovary
Health Related Quality of Life and Psychological Parameters in Different Polycystic Ovary Syndrome Phenotypes: A Comparative Cross-Sectional Study
Authors: Bahadori Fatemeh , Sadatmahalleh shahideh Jahanian , Mirzaei Negin 
Published: December 2020

Abstract
Background: Polycystic ovary syndrome (PCOS) is associated with high levels of phsychological implications and detriments to quality of life (QoL). The aim of this study was to assess the quality of life (QoL), health related quality of life (HRQoL), depression, and anxiety in Iranian women with different PCOS phenotypes.Methods: The observational, cross-sectional study was carried out on 239 PCOS women PCOS which had been classified on the basis of Rotterdam criteria into four categories. Then they were classified into four groups according to the Rotterdam criteria: A (n=77), B (n=38), C (n=68), and D (n=56).Results: No significant differences were observed between the four PCOS phenotypes for anxiety, depression and QoL, likewise, HRQoL domains related to infertiliy, weight and emotional problems (P>0.05). Phenotypes A and B had worse HRQoL related to hirsutism (13.98±5.22, 14.13±6.23, P<0.001), also no significant differences were observed between them for HRQoL’s domains. While the score of acne in phenotype D (19.60±5.12, P=0.003) and menstrual score in phenotype C were significantly higher compare with the other PCOS groups (16.82±3.87, P<0.001). Conclusion: Presenting similar psychological profile in all phenotypes unveils the importance of pychological well-being screening, even in milder reproductive phenotypes.
A Comparison of the Analgesic Efficacy of Serratus Anterior Plane Block Vs Paravertebral Nerve Block for Video-assisted Thoracic Surgery: a Randomized Controlled Trial
Authors: Zhang Yi , Fu Ze , Fang Te , Wang Kexin , Liu Zimeng , Li Hongqing , Jiang Wenwen , Cao Xuezhao 
Published: December 2020

Abstract
Background: Patients who undergo video-assisted thoracic surgery (VATS) that impair the integrity of the chest wall frequently experience moderate to severe postoperative pain. Serratus anterior plane block (SAPB) is a relatively novel technique that can block the lateral cutaneous branches of the intercostal nerves as well as the long thoracic nerve. Methods: Our study aimed to evaluate the analgesic efficiency of deep serratus plane block (DSPB) and superficial serratus anterior plane block (SSPB) as well as paravertebral nerve block (PVB) in the patients undergoing VATS. A total of 74 patients aged from 20-80 undergoing VATS were randomized to receive either DSPB or SSPB as well as PVB. Ultrasound (US) guided DSPB or SSPB as well as PVB with 20ml 0.5% ropivacaine was performed preoperatively to the patients according to their groups. All patients were provided with patient-controlled intravenous analgesia (PCIA) for postoperative analgesia. The primary outcomes were the levels of postoperative pain at rest and on coughing evaluated by visual analog scale (VAS), intraoperative and postoperative opioids consumption. The secondary outcomes included PCIA pressed times, side effects and satisfaction of analgesia, duration of nerve block, intraoperative hemodynamic changes and vasoactive drug dosage. Results: No significant differences of VAS score were found in the three groups at each time points. During operation, PVB reduced consumption of opioids (27.23±5.10mg) compared to DSPB (31.20±3.80mg) and SSPB (32.61±5.28mg) (p<0.05). The effective pressed times of PCIA in SSPB group (0.18±0.65) was significantly lower compared to PVB group (1.09±1.50) (p=0.009) at postoperative 12h. Accordingly, SSPB group reduced the dosage of PCIA (26.55±4.72ml) than PVB group (31.45±7.60ml) (p=0.046). Time consuming of PVB procedure was longer (11.14±1.66min) than DSPB (5.68±1.10min) and SSPB (4.77±1.04min) (p<0.001, respectively). PVB group was associated with more intraoperative atropine consumption (0.14±0.24mg) than DSPB group (0mg) (P=0.043). Conclusion: DSPB and SSPB are easy to perform and can serve as a promising alternative technique to PVB that may offer comparable analgesic effectiveness and a better side-effect profile for patients who undergoing VATS. Trial registration: This study was registered to Chinese Clinical Trials Registry on July 20, 2019. (Registration No: ChiCTR1900024678)