bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digitalization as a catalyst for social sustainability in supply chains: an ISM-fuzzy MICMAC and DEMATEL approach
Authors: Öztürk Cihat 
Published: February 2025

Abstract
This study explores the transformative role of digitalization in enhancing social sustainability within supply chains. Social sustainability, a critical dimension alongside economic and environmental sustainability, aims to balance environmental health and financial stability by improving the quality of life within supply chain networks. Digital technologies introduced by Industry 4.0 and further developed by Industry 5.0 have significantly impacted various aspects of social sustainability. We investigate the interactions and significance of social sustainability enablers influenced by these technologies. Key enablers include worker well-being support, skills development, and equitable educational opportunities. To perform this analysis, we employ the ISM-Fuzzy MICMAC (Matrice d’Impacts Croisés Multiplication Appliquée à un Classement) and DEMATEL (Decision Making Trial and Evaluation Laboratory) methods, which are widely recognized in the literature for their effectiveness. Our findings provide a strategic roadmap for supply chain stakeholders by highlighting the complex relationships between digitalization and social sustainability enablers. We identify key enablers such as digital inclusion, privacy, digital skills, visibility, innovative business design, decision-making, education, and capacity building to achieve a more human-centered and sustainable supply chain. The results clearly reveal the relationships among these enablers, forming a hierarchical structure that underscores their interactions. Additionally, this study contributes to the existing literature by addressing the often-overlooked social dimension of sustainability, offering practical insights for policymakers and business leaders on leveraging digital technologies for sustainable development.
Molecular Chimera in Cancer Drug Discovery: Beyond Antibody Therapy, Designing Grafted Stable Peptides Targeting Cancer
Authors: Chowdhury Arpan , Shrestha Prajesh , Jois Seetharama D. 
Published: February 2025

Abstract

Background
Several cancer therapies are being developed, and given the variability of different cancer types, the goal of these therapies is to remove the invasive tumor from the body, kill the cancer cells, or else retard the growth. These include chemotherapeutic agents and targeted therapy using small molecules and antibodies. However, antibodies can generate an immune response upon repeated administration, and producing antibodies could be expensive.

Purpose
The purpose of this review is to describe different therapeutic approaches utilized for cancer therapy, the current therapeutic approaches, and their limitations. As a novel strategy to combat cancer, designing new stable peptide scaffolds such as cyclotides and sunflower trypsin inhibitors (SFTI) is described.

Results
Stable peptides that can target proteins can be used as therapeutic agents. Here, we review the utilization and amalgamation of plant-based peptides with biological epitopes in designing molecules called “Molecular Chimeras” using a grafted peptide strategy. These cyclic peptides can bind to target receptors or modulate protein-protein interactions as they bind with high affinity and selectivity. Grafted peptides also possess better serum stability owing to the head-to-tail cyclization and other structural modifications.

Conclusion
Stable cyclic peptides outweigh the other biologicals in terms of stability and manufacturing process. Peptides and peptidomimetics can be used as therapeutic agents, and these molecules provide alternatives for biologicals and small molecule inhibitors as drugs.
T-type calcium channels regulate medulloblastoma and can be targeted for therapy
Authors: Dube Collin J. , Lai Michelle , Zhang Ying , Saha Shekhar , Yener Ulas , Hanif Farina , Hudson Kadie , Gibert Myron K. , Marcinkiewicz Pawel , Sun Yunan , Vegiraju Tanvika , Xu Esther , Sorot Aditya , Gallagher Rosa I. , Wulfkuhle Julia D. , Vernon Ashley , Dell’Olio Lily , Anbu Rajitha , Mulcahy Elizabeth , Kefas Benjamin , Guessous Fadila , Petricoin Emanuel F. , Abounader Roger 
Published: February 2025

Abstract

Purpose
The goal of this study was to investigate the role and therapeutic targeting of T-type calcium channels in medulloblastoma, a common and deadly pediatric brain tumor that arises in the cerebellum.

Methods
T-type calcium channel expression was assessed in publicly available bulk and single cell RNA-seq datasets. The effects of T-type calcium channel blocker mibefradil on cell growth, death and invasion were assessed with cell counting, alamar blue, trypan blue and transwell assays. Proteomic-based drug target and signaling pathway mapping was performed with Reverse Phase Protein Arrays (RPPA). Co-expression modules of single cell RNA-seq data were generated using high dimensional weighted gene co-expression network analysis (hdWGCNA). Orthotopic xenografts were used for therapeutic studies with the T-Type calcium channel blocker mibefradil.

Results
T-type calcium channels were upregulated in more than 30% of medulloblastoma tumors and patients with high expression associated with a worse prognosis. T-type calcium channels had variable expression across all the subgroups of medulloblastoma at the bulk RNA-seq and single-cell RNA-seq level. Mibefradil treatment or siRNA mediated silencing of T-type calcium channels inhibited tumor cell growth, viability and invasion. RPPA-based protein/phosphoprotein signal pathway activation mapping of T-type calcium channel inhibition and single cell hdWGCNA identified altered cancer signaling pathways. Oral administration of mibefradil inhibited medulloblastoma xenograft growth and prolonged animal survival.

Conclusion
Our results represent a first comprehensive multi-omic characterization of T-type calcium channels in medulloblastoma and provide preclinical data for repurposing mibefradil as a treatment strategy for these relatively common pediatric brain tumors.
Optimizing flexibility in power systems by maximizing the region of manageable uncertainties
Authors: Zingler Aron , Fliscounakis Stéphane , Panciatici Patrick , Mitsos Alexander 
Published: February 2025

Abstract
Motivated by the increasing need to hedge against load and generation uncertainty in the operation of power grids, we propose flexibility maximization during operation. We consider flexibility explicitly as the amount of uncertainty that can be handled while still ensuring nominal grid operation in the worst case. We apply the proposed flexibility optimization in the context of a DC flow approximation. By using a corresponding parameterization, we can find the maximal range of uncertainty and a range for the manageable power transfer between two parts of a network subject to uncertainty. We formulate the corresponding optimization problem as an (existence-constrained) semi-infinite optimization problem and specialize an existing algorithm for its solution.
Recovery trajectories after a serious injury or illness: a longitudinal evaluation of health-related quality of life in an Australian cohort
Authors: Afoakwah Clifford , Kuwornu Paul , Koomson Isaac , Brain David , Xia Qing , McPhail Steven , Vallmuur Kirsten 
Published: February 2025

Abstract

Purpose
Serious injuries or illnesses impose a significant burden on the affected individuals. This study examined the long-term recovery of health-related quality of life (HRQoL) after a serious injury or illness and quantified the economic costs attributable to the quality-adjusted life-years (QALYs) lost to serious injury or illness.

Methods
Data were sourced from the Household, Income and Labour Dynamics in Australia (HILDA) database. The propensity score matching-difference-in-differences (PSM-DiD) method was used to explore the recovery of HRQoL over a six-year follow-up period. HRQoL was measured by the short-form six-dimension utility index, physical health, and mental health.

Results
We found that those who suffered any serious injuries or illnesses had a decline of 0.020 in QALYs during the year of event, reducing further until a trough of 0.032 by the third year and thereafter began to recover. Further analyses revealed that although serious injuries or illnesses had a significantly greater loss in physical health, the loss in mental health persisted over a longer period. Finally, the economic cost associated with the lost in QALYs due to serious injuries or illnesses was estimated at $685 per person during the year of event and increased to a peak of $1,250 per person by the end of the third-year post-exposure.

Conclusion
Our findings highlight that follow-up care designed to mitigate the impacts of a serious injury or illness on people’s HRQoL should consider cost-effective strategies that are long-lasting and support those affected throughout at least, the first three years of their injuries or illnesses.
Keetia magassoubiana sp. nov. (Rubiaceae - Vanguerieae), a threatened evergreen forest climber and an updated key to Keetia in West Africa
Authors: Cheek Martin , Yasuda Shigeo , Jongkind Carel C. H. , Bowden-Pickstock Joel 
Published: February 2025

Summary

Keetia magassoubiana Cheek, an evergreen rainforest climber, is described and illustrated from the Republic of Guinea, Sierra Leone, Liberia and Ivory Coast. Previously indicated as being close to, but different from, K. tenuiflora (Hiern) Bridson, it differs in the glossy, black, glabrous, epidermis of the distal stem internodes; the first internode rarely with very sparse, red adpressed hairs (vs epidermis pale white-brown, with dense, pale yellow, spreading hairs); abaxial leaf surfaces with domed domatia with a central aperture (vs domatia absent or obscure); secondary stem leaf bases acute (vs obtuse to truncate); bracts forming a laciniate sheath on the distal peduncle (vs two opposite triangular bracts) and the pyrene surface honeycombed with pits (vs entire). The species was earlier included within Canthium multiflorum (Schum. & Thonn.) Hiern, now K. multiflora (Schum. & Thonn.) Bridson, in the Flora of West Tropical Africa, second edition. An updated key is presented to the 16 species of the genus from West Africa. Keetia magassoubiana is provisionally assessed using the IUCN standard as Endangered [EN B1ab(iii)] due to only five of the recorded 14 locations having extant forest habitat, and because of ongoing threats of habitat clearance, mainly for agriculture but also for mining.
Remarks of Optical Fibers and Devices for Microfluidic Sensing: Preparation and Processing
Authors: Zhang Xiaotong , Yuan Tingting 
Published: February 2025

Abstract
With the gradual maturity of the microfluidic technology, the integration of the microfluidic chip technology and optofluidic methods in microstructured optical fibers (MOFs) has gradually formed a highly attractive new research direction. In this paper, we summarize our recent work focusing on the microfluidic sensing technology based on microhole fibers. The design and fabrication of such microfluidic fibers, device processing and fabrication techniques based on microfluidic fibers, and surface modification and coating methods for fibers are systematically introduced. Finally, several typical cases combining the optical fiber and microfluidic substance detection are presented.
New sufficient conditions for p-valent functions
Authors: Güney Hatun Özlem , Sümer Sevtap , Owa Shigeyoshi 
Published: February 2025

Abstract
Let

$$\mathcal {A}_{p}$$

A
p

be the class of functions f(z) of the form

$$ f(z)=z^{p}+a_{p+1}z^{p+1}+a_{p+2}z^{p+2}+\cdots , (p\in \mathbb {N}=\{1,2,3,\ldots \}) $$

f

(
z
)

=

z
p

+

a

p
+
1

z

p
+
1

+

a

p
+
2

z

p
+
2

+
⋯
,

(
p
∈
N
=

{
1
,
2
,
3
,
…
}

)

that are analytic in the open unit disc

$$\mathbb {U}=\big \{ z\in \mathbb {C}: |z| <1\big \}$$

U
=

{

z
∈
C
:
|
z
|
<
1

}

. For

$$f(z)\in \mathcal {A}_{p}$$

f

(
z
)

∈

A
p

, Nunokawa considered some conditions such that f(z) is

$$p-$$

p
-

valent in

$$\mathbb {U}$$

U

. Applying the results by Nunokawa, we discuss some interesting properties for functions

$$f(z)\in \mathcal {A}_{p}$$

f

(
z
)

∈

A
p

. Also, we give some examples for our results.
What predicts environmental stewardship (climate intentions) and beliefs about climate change in Ghana: religion (faith) or science?
Authors: Agyei De-Graft Nana , Dzokoto Vivian Afi , Ameko Stephen Kwame , Anum Adote 
Published: February 2025

Abstract
We investigated the predictive role of religious and scientific beliefs on climate attitudes among 286 participants from two communities in southern Ghana. Using structural equation modeling, we examined whether specific religious variables (intrinsic religious orientation, extrinsic religious orientation, and religious conviction) and science variables (interest in gaining science and technology knowledge and belief in science’s benefit to humankind) predicted climate beliefs and intentions (measured as environmental stewardship). Our results indicated that intrinsic religious orientation and religious conviction significantly predicted climate beliefs but not climate intentions. Extrinsic religious orientation did not predict climate beliefs but had an inverse effect on climate intentions. Additionally, interest in science and technology knowledge, as well as the belief that science is beneficial to humankind, was positively related to climate beliefs but not climate intentions. These findings contribute to our understanding of the influence of religious and scientific beliefs on climate attitudes, highlighting the need for nuanced approaches to addressing climate change in Ghana.
Dissipative MHD bio-convective flow of radiative Jeffery nanofluid through a vertical permeable cone
Authors: Mkhatshwa M. P. 
Published: February 2025

Abstract
Thermal limitations of Jeffrey fluids restrict their broader industrial applications. To address this drawback, nanofluids with superior thermal properties have been introduced, though instability due to nanoparticles remains a challenge. The incorporation of motile microorganisms mitigates this issue by enhancing thermal conductivity and mass transport, stabilizing the suspension. This study investigates the magnetized bio-convective flow of a radiative Jeffrey nanofluid with motile microorganisms over a vertical permeable cone embedded in porous media, considering viscous dissipation under uniform heat and nanoparticle flux conditions. By introducing appropriate dimensionless variables, the model equations have been transitioned into non-dimensional partial differential equations and then solved using the overlapping grid-based multi-domain spectral collocation method. The numerical results for flow profiles and engineering-relevant quantities are analyzed for various flow parameters. Key findings reveal that the Deborah number, magnetic field strength, suction intensity, and porous media accelerate fluid flow, while radiative heat flux improves thermal distribution and the rate of heat conveyance. Also, intense random motion of nanoparticles and active movement of motile microbes contribute to increasing the nanoparticle mass transfer rate and density number of motile microbes.
BMI1s interact with condensin complexes to regulate chromatin 3D structure and gene expression in Arabidopsis
Authors: Luo Lingxiao , Yang Minqi , Zhou Yue 
Published: February 2025

Abstract
The accurate chromatin states are essential for maintaining genome integrity and ensuring the normal transcription of genes. Polycomb group (PcG) proteins regulate chromatin states not only by modifying the chromatin, but also by influencing the chromatin three-dimensional (3D) structure. The core components of Polycomb repressive complex 1 (PRC1), B LYMPHOMA MOLONEY MURINE LEUKEMIA VIRUS INSERTION REGION 1 HOMOLOG 1A/B/C (BMI1s), have been reported to maintain the compartment domains (CDs) generally, but the mechanism by which they function remains elusive. Here, we reveal that condensin complexes, whose function are related to chromatin or chromosome, can interact with BMI1s. Removal of condensin I or II also leads to global impairment of CDs. The significantly impaired CDs in bmi1a/b/c and condensin mutants are basically the same and the CDs co-regulated by BMI1s and condensin complexes have higher strength in the wild-type (WT, Col-0) plant, indicating that BMI1s and condensin complexes cooperate to maintain CDs. This regulatory function is parallel to the function of histone modifications deposited by PcG in maintaining CDs, since removal of either condensin I or II does not obviously disrupt the genome-wide level of H3K27me3 and H2AK121ub. Moreover, we discovered that BMI1s and condensin complexes jointly influence the expression of a portion of genes to enable normal plant growth and may maintain the genome integrity under stress conditions. Thus, our work proides a perspective for the gene expression and epigenetic regulatory mechanism of PRC1, in Arabidopsis, in addition to histone modifications.
Do not treat ghosts: anti-methicillin-resistant Staphylococcus aureus (MRSA) therapy in osteomyelitis without identified MRSA
Authors: Varughese Jincy , Halfman Annie , Crotty Matthew , Alexander Julie , Hunter Leigh , Hupert Mark , Dominguez Edward 
Published: February 2025

Abstract

Objective:
To compare the clinical outcomes of patients with lower limb osteomyelitis (LLOM) and negative methicillin-resistant Staphylococcus aureus (MRSA) cultures treated with anti-MRSA therapy (AMT) versus those treated with no-anti-MRSA therapy (NAMT).

Design:
Retrospective cohort study.

Patients:
Hospitalized adult (≥18 yr of age) patients admitted to multiple tertiary referral centers in a single healthcare system between April 1, 2017 and April 1, 2023, with LLOM and planned intravenous antibiotics for at least four weeks.

Methods:
Electronic medical records were queried for demographic information, admission dates, treatment strategies, imaging and culture results, and discharge diagnoses. Descriptive statistics measured baseline characteristics, imaging, and culture results.

Results:
Out of 473 patients, 64 met the inclusion criteria and 409 were excluded. Of the 64 patients, 26 (40%) had AMT and 38 (59%) had NAMT. A larger but statistically insignificant portion of patients in the NAMT cohort failed therapy (23% AMT vs 32% NAMT, P = 0.325). However, hospital readmission for LLOM within 180 days of antibiotic completion (46.2% vs 47%, P = 0.92), hospital length of stay (median (IQR): 6 (5–9) d vs 7 (5–12.5) d, P = 0.285), incidence of new renal replacement therapy initiation (0% vs 2.6%, P = 0.594), creatinine kinase levels (0 vs 2.6%, P = 0.594), and drug-induced immune thrombocytopenia (0% vs 5.3% P = 0.349) were comparable between the two cohorts.

Conclusions:
Treatment failure rates and adverse events did not differ significantly among patients with LLOM treated with AMT or NAMT. Further investigation of determinants of clinical failures in LLOM may help optimize overall treatment.
The role of carbonate equilibrium in scale formation of calcium carbonate in a power plant open recirculating system
Authors: Kuznietsov Pavlo , Biedunkova Olha 
Published: February 2025

Abstract
The principal function of an open recirculating system (ORS) is to remove heat from power plant equipment. In particular, the presence of scale on the internal surfaces of ORS heat exchange equipment can reduce heat transfer efficiency, which leads to increased energy consumption and operating costs. The purpose of this article is to investigate the process of calcium carbonate (CaCO3) precipitation formation in terms of the components of the carbonate system and parameters affecting the shift of carbonate equilibrium in an ORS. An appraisal model was used to represent the processes occurring during the operation of an ORS. In this study, it is demonstrated that water heating in ORS condensers leads to the excretion of carbon dioxide (CO2) from the water, while cooling in the cooling towers results in CO2 uptake by the water. These processes significantly influence the state of carbonate equilibrium within the ORS. The study used the results of chemical control of the make-up and cooling water at the ORS Rivne Nuclear Power Plant (RNPP) for 2022. Furthermore, the dependencies of changes in the components of the carbonate system on the pH levels of the make-up (pH 7.51–9.52) and cooling (pH 8.21–9.53) water were revealed, and changes in the cycles of concentration (CоC), total hardness (TH), total dissolved solids (TSD), and total alkalinity (TA) were estimated. Taking into account the obtained correlation dependencies, in general, it was found that the lower the CoC levels, the lower the TA reduction value, and it is possible to increase or decrease the cooling water pH levels, which is determined by the initial state of carbonate equilibrium of make-up water. These findings enable the prediction and control of CaCO3 scale formation through continuous monitoring of water chemistry, making the process more efficient, reliable, and sustainable. The results emphasize the importance of data-driven modeling for optimizing water treatment and reducing operational costs in power plants by reducing CaCO3 scale formation.
Having a monk in the family and all-cause mortality: a seven-year prospective cohort study
Authors: Zhou Liqiong , Chen Yuan , Ge Erhao , Zhang Aijie , Zhang Yasi , Du Juan , Mace Ruth , Zhan Yiqiang 
Published: February 2025

Abstract

Religious celibate monks at the household level possibly reduce all-cause mortality risk among non-monk older Tibetans. This study aims to investigate the association between having a celibate monk in a family and the all-cause mortality of non-monk household members in a Tibetan population. Baseline interviews were conducted for 713 agropastoral Amdo Tibetans aged ≥50 years residing in the eastern Tibetan Plateau from 2016 to 2017. The Cox mixed-effects regression model was used to estimate the association between having a celibate monk in a household and the mortality risk of other non-monk household members. Potential confounders included age, sex, household size, educational attainment, household wealth (measured as the number of yaks), marital status, and annual expenditure. During a median follow-up of 7 years, 54 deaths were identified. The results showed that people living in households with celibate monks had a lower risk of all-cause mortality (hazard ratio: 0.31, 95% confidence interval: 0.14, 0.67) as compared with those living in households without celibate monks. The results remained robust after controlling for confounders, suggesting that religious celibate monks at the household level were associated with lower all-cause mortality among non-monk older household members.
Explosion and Reasoning
Authors: Sgaravatti Daniele 
Published: February 2025

Abstract
The paper responds to two recent versions of the argument against ex contradictione quodlibet (the principle that says that a contradiction entails any proposition, also known as ‘explosion’) based on the normative role of logic for reasoning. Both versions of the argument I am concerned with assume that a subject has defeasible reasons to believe any logical consequence of her beliefs. After showing this assumption to be more controversial than it might seem, I argue that even if it is true, and assuming ex contradictione quodlibet, no absurdity follows about what reasons the subject with inconsistent beliefs has. There is an independent explanation of the fact that a subject with inconsistent beliefs is not in a position to rationally infer anything. The reasons that derive from the inconsistency, if there are any, are a of peculiar kind, which I call inert reasons.