bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of failed therapy evaluations in radioembolization of primary and secondary liver cancers
Authors: Masthoff Max , Schindler Philipp , Harders Fabian , Heindel Walter , Wilms Christian , Schmidt Hartmut H. , Pascher Andreas , Stegger Lars , Rahbar Kambiz , Köhler Michael , Wildgruber Moritz 
Published: November 2020

Abstract
Purpose
To analyze patients’ characteristics and reasons for not performing planned transarterial radioembolization (TARE) in liver cancer after 99mTc-labeled macroaggregated albumin (99mTc-MAA) evaluation.

Methods
In this retrospective single-center cohort, all patients undergoing 99mTc-MAA evaluation prior to planned TARE for primary or secondary liver cancer between 2009 and 2018 were analyzed. Patients were assigned to either “TARE” or “no TARE” group. Patients’ characteristics, arising reasons for not performing the planned TARE treatment as well as predictive factors for occurrence of these causes were analyzed.

Results
436 patients [male = 248, female = 188, median age 62 (23–88) years] with 99mTc-MAA evaluation prior to planned TARE of primary or secondary liver cancer were included in this study. 148 patients (33.9%) did not receive planned TARE. Patients with a hepatic tumor burden > 50%, no liver cirrhosis, no previous therapies and a higher bilirubin were significantly more frequent in “no TARE” compared to “TARE” group. Main reasons for not performing TARE were extrahepatic tracer accumulation (n = 70, 40.5%), non-target accumulation of 99mTc-MAA (n = 27, 15.6%) or a hepatopulmonary shunt fraction of more than 20% (n = 23, 13.3%). Independent preprocedural parameters for not performing planned TARE were elevated bilirubin (p = 0.021) and creatinine (p = 0.018) and lower MELD score (p = 0.031).

Conclusion
A substantial number of patients are precluded from TARE following 99mTc-MAA evaluation, which is, therefore, implicitly needed to determine contraindications to TARE and should not be refrained from in pretreatment process. However, a preceding careful patient selection is needed especially in patients with high hepatic tumor burden and alteration in lab parameters.
Can search result summaries enhance the web search efficiency and experiences of the visually impaired users?
Authors: Aqle Aboubakr , Al-Thani Dena , Jaoua Ali 
Published: November 2020

AbstractThere are limited studies that are addressing the challenges of visually impaired (VI) users when viewing search results on a search engine interface by using a screen reader. This study investigates the effect of providing an overview of search results to VI users. We present a novel interactive search engine interface called InteractSE to support VI users during the results exploration stage in order to improve their interactive experience and web search efficiency. An overview of the search results is generated using an unsupervised machine learning approach to present the discovered concepts via a formal concept analysis that is domain-independent. These concepts are arranged in a multi-level tree following a hierarchical order and covering all retrieved documents that share maximal features. The InteractSE interface was evaluated by 16 legally blind users and compared with the Google search engine interface for complex search tasks. The evaluation results were obtained based on both quantitative (as task completion time) and qualitative (as participants’ feedback) measures. These results are promising and indicate that InteractSE enhances the search efficiency and consequently advances user experience. Our observations and analysis of the user interactions and feedback yielded design suggestions to support VI users when exploring and interacting with search results.
Using a multi-stakeholder approach to increase value for traditional agroforestry systems: the case of baobab (Adansonia digitata L.) in Kilifi, Kenya
Authors: Meinhold Kathrin , Darr Dietrich 
Published: November 2020

AbstractThe baobab tree (Adansonia digitata L.) is an integral component of many dryland farming systems in sub-Sahara Africa. Such traditional agroforestry systems can foster a variety of benefits; besides positive livelihood implications baobab can particularly address food security objectives due to its highly nutritious fruits. However, many bottlenecks persist inhibiting the broader potential of indigenous trees in farming systems and their increased utilisation and commercialisation. We suggest that traditional farming systems with baobab trees can be advanced by stimulating the emergence of local markets for baobab products while promoting businesses and innovations aimed at meeting the arising market demand. Increasing the perceived value of local agroforestry products in combination with facilitating additional commercialisation pathways will in turn lead to food security and livelihood benefits. Using a multi-stakeholder approach such considerations were put into practice in Kilifi, Kenya, by initiating a community-based enterprise development producing high-quality baobab powder and oil. Initial results demonstrate behavioural changes, an improved practical knowhow with regard to baobab management and utilisation, and an increased consumption of baobab, which may already contribute to food security objectives. Baobab is increasingly seen as a valuable resource as opposed to ‘food for the poor’ and a tree possessed by evil spirits. This may lay the groundwork for further value addition activities and enterprise development in the communities. With baobab being a common, yet so far underutilised feature of local farming systems in Kilifi, activities based on its increasing commercialisation can be complementary and easily integrable to prevailing livelihood strategies.
Knock out of sHSP genes determines some modifications in the probiotic attitude of Lactiplantibacillus plantarum
Authors: Longo Angela , Russo Pasquale , Capozzi Vittorio , Spano Giuseppe , Fiocco Daniela 
Published: November 2020

Abstract
Objective
We investigated whether the knock out of small heat shock protein (sHSP) genes (hsp1, hsp2 and hsp3) impact on probiotic features of Lactiplantibacillus plantarum WCFS1, aiming to find specific microbial effectors involved in microbe-host interplay.

Results
The probiotic properties of L. plantarum WCFS1 wild type, hsp1, hsp2 and hsp3 mutant clones were evaluated and compared through in vitro trials. Oro-gastro-intestinal assays pointed to significantly lower survival for hsp1 and hsp2 mutants under stomach-like conditions, and for hsp3 mutant under intestinal stress. Adhesion to human enterocyte-like cells was similar for all clones, though the hsp2 mutant exhibited higher adhesiveness. L. plantarum cells attenuated the transcriptional induction of pro-inflammatory cytokines on lipopolysaccharide-treated human macrophages, with some exception for the hsp1 mutant. Intriguingly, this clone also induced a higher IL10/IL12 ratio, which is assumed to indicate the anti-inflammatory potential of probiotics.

Conclusions
sHSP genes deletion determined some differences in gut stress resistance, cellular adhesion and immuno-modulation, also implying effects on in vivo interaction with the host. HSP1 might contribute to immunomodulatory mechanisms, though additional experiments are necessary to test this feature.
Exploring Violent Cosmologies From a “Radical Interactionist” Approach
Authors: Ceretti Adolfo , Natali Lorenzo 
Published: November 2020

AbstractThis article advances a theoretical perspective on violent crime, using interviews with male prisoners in Italy who had perpetrated violence. By drawing on Athens’ (1992, 1997, 2007, 2017) “radical interactionism,” we propose the concept of “violent cosmology” in order to counter linear explanations of cause and effect. In an effort to complement narrative criminologists’ contributions, we seek to recognize and understand the dimensions of meaning that are accessed by social actors when they prepare and carry out a violent act, exploring the psycho-social processes that animate violent social experiences from the perspectives of perpetrators. Specifically, we suggest that a “radical interactionist” approach, in dialogue with narrative criminology, can help (1) illuminate the sources of perpetrators’ narratives; (2) explore the interplay between individuals and social structures; and (3) investigate ambiguities in the narratives of violent actors. Finally, we examine how enhancing the reflexivity of violent actors and recognizing the specificity and integrity of their lives and social experiences is a necessary precondition for understanding violent crime.
Universal Design of ICT for Emergency Management from Stakeholders’ Perspective
Authors: Gjøsæter Terje , Radianti Jaziar , Chen Weiqin 
Published: November 2020

AbstractWhile Universal Design principles have been adopted in many areas to ensure that products and services are usable for the broadest possible diversity of users, there is still an open area when it comes to the emergency management domain. This article aims at providing a systematic overview of the current state of the emerging research field of Universal Design of Information and Communication Technology (ICT) for Emergency Management, and to highlight high-impact research opportunities to ensure that the increasing introduction of ICT in Emergency Management can contribute to removing barriers instead of adding more barriers, in particular for the elderly and people with disabilities. A systematic review on relevant literature on Universal Design, ICT and Emergency Management between 2008 and 2020 was employed using predefined frameworks, to answer the following questions: (1) Who are the target audiences (stakeholders) in research on Universal Design of ICT in Emergency Management in the different categories of Emergency Management ICT tools, and to what degree is Human-Centred Design and Universal Design taken into account? (2) What are the most important challenges and gaps in research on Universal Design of ICT in Emergency Management? We identify a set of gaps in the literature, indicating that there are some challenges where Universal Design is still limitedly addressed in technology development. We also derive promising future research topics based on areas that are missing in the literature.
Identifying Areas of Overlap and Distinction in Early Lexical Profiles of Children with Autism Spectrum Disorder, Late Talkers, and Typical Talkers
Authors: Jiménez Eva , Haebig Eileen , Hills Thomas T. 
Published: November 2020

Abstract This study compares the lexical composition of 118 children with autism spectrum disorder (ASD) aged 12 to 84 months with 4626 vocabulary-matched typically developing toddlers with and without language delay, aged 8 to 30 months. Children with ASD and late talkers showed a weaker noun bias. Additionally, differences were identified in the proportion of nouns and verbs, and in the semantic categories of animals, toys, household items and vehicles. Most differences appear to reflect the extent of the age differences between the groups. However, children with ASD produced fewer high-social verbs than typical talkers and late talkers, a difference that might be associated with ASD features. In sum, our findings identified areas of overlap and distinction across the developing lexical profiles.
Serving Rural Veterans with Disabilities: A National Survey of Centers for Independent Living
Authors: Hale-Gallardo Jennifer , Kreider Consuelo M. , Ni Yuxin , Semeah Luz M. , Ahonle Zaccheus J. , Cowper-Ripley Diane C. , Mburu Sharon , Delisle Anthony T. , Jia Huanguang 
Published: November 2020

AbstractThis study comprises a systematic national examination of how Centers for Independent Living can and do support Veteran consumers, especially those living in rural communities. This research provides contextualized understanding of rural Veteran needs for community-based services and resources available through Centers for Independent Living. A survey was administered to the leadership of 383 Centers for Independent Living throughout the United States, the majority of which have rural catchment areas and serve rural Veterans through both main and satellite offices. Descriptive univariate analysis was used to describe responses. Study respondents represented a total of 39 states, with 20% of respondents reporting that their consumers were 100% rural and only 3% entirely urban. Services and supports from Centers for Independent Living provided to rural Veterans most frequently included housing, transportation, and peer support. Approximately half of all Centers for Independent Living reported tracking the status of their Veteran consumers.
Modeling of Chemical Reaction Systems with Detailed Balance Using Gradient Structures
Authors: Maas Jan , Mielke Alexander 
Published: November 2020

AbstractWe consider various modeling levels for spatially homogeneous chemical reaction systems, namely the chemical master equation, the chemical Langevin dynamics, and the reaction-rate equation. Throughout we restrict our study to the case where the microscopic system satisfies the detailed-balance condition. The latter allows us to enrich the systems with a gradient structure, i.e. the evolution is given by a gradient-flow equation. We present the arising links between the associated gradient structures that are driven by the relative entropy of the detailed-balance steady state. The limit of large volumes is studied in the sense of evolutionary$$\Gamma $$Γ-convergence of gradient flows. Moreover, we use the gradient structures to derive hybrid models for coupling different modeling levels.
Online vs. offline course evaluation revisited: testing the invariance of a course evaluation questionnaire using a multigroup confirmatory factor analysis framework
Authors: Laupper Ellen , Balzer Lars , Berger Jean-Louis 
Published: November 2020

AbstractSurvey-based formats of assessing teaching quality in higher education are widely used and will likely continue to be used by higher education institutions around the world as various global trends contributing to their widespread use further evolve. Although the use of mobile devices for course evaluation continues to grow, there remain some unresolved aspects of the classic paper and web-based modes of evaluation. In the current study, the multigroup confirmatory factor analysis approach (MGCFA), an accepted methodological approach in general mixed-method survey research, was chosen to address some of the methodological issues when comparing these two evaluation modes. By randomly assigning one of the two modes to 33 continuing training courses at a Swiss higher education institution, this study tested whether the two different modes of assessing teaching quality yield the same results. The practical implications for course evaluation practice in institutions of higher education as well as the implications and limitations of the chosen methodological approach are discussed.
Non-potable Water Quality Assessment Methodology for Water Conservation in Arid Climates
Authors: Seguela Geraldine , Littlewood J. R. , Karani G. 
Published: November 2020

Abstract
This paper documents a non-potable water (NPW) quality assessment methodology for a decentralized non-potable water system in Abu Dhabi (AD), capital city of the United Arab Emirates (UAE), which is dominated by sandy and salty soil, high temperature, and humidity. The context is a medical facility case study (MFCS) in AD, which includes a landscape 50% as large as its building footprint. The project identified the need to investigate the impact of air handling unit (AHU) air conditioning (A/C) condensate water (CW) quality on soil health and building hydraulic systems. The aim of the research was to measure the impact of using recycled on-site NPW sources in a MFCS in AD, to alleviate the use of desalinated potable water and reduce associated energy consumption, operation cost, and greenhouse gas emissions for landscape irrigation (LI) and water feature (WF) use. CW has been tested in 2016 and in 2017 and analysed against local authority’s parameter limits to establish suitability for LI and WF use. The findings are that in AD CW classification and characterization is a gap in knowledge whereby salinity and toxicity concentration limits should be addressed by the local authority because CW has an impact on soil infiltration rate due its low dissolved salt content as evidenced by the water test results. The recommendations for this paper are to develop a sustainable water conservation and reuse (SWC) strategy forming the basis for a water protocol by the competent authority for regional medical facility including a methodology for assessing on-site NPW quality for outdoor reuse to reduce soil infiltration problems and consequently conserve water and associated energy. The next steps are to confirm if the MFCS soil infiltration rate is affected by the CW or other factors, and to test additional NPW types.
Predicting Violence in Merseyside: a Network-Based Approach Using No Demographic Information
Authors: Campana Paolo , Giovannetti Andrea 
Published: November 2020

Abstract
Purpose
We explore how we can best predict violent attacks with injury using a limited set of information on (a) previous violence, (b) previous knife and weapon carrying, and (c) violence-related behaviour of known associates, without analysing any demographic characteristics.

Data
Our initial data set consists of 63,022 individuals involved in 375,599 events that police recorded in Merseyside (UK) from 1 January 2015 to 18 October 2018.

Methods
We split our data into two periods: T1 (initial 2 years) and T2 (the remaining period). We predict “violence with injury” at time T2 as defined by Merseyside Police using the following individual-level predictors at time T1: violence with injury; involvement in a knife incident and involvement in a weapon incident. Furthermore, we relied on social network analysis to reconstruct the network of associates at time T1 (co-offending network) for those individuals who have committed violence at T2, and built three additional network-based predictors (associates’ violence; associates’ knife incident; associates’ weapon incident). Finally, we tackled the issue of predicting violence (a) through a series of robust logistic regression models using a bootstrapping method and (b) through a specificity/sensitivity analysis.

Findings
We found that 7720 individuals committed violence with injury at T2. Of those, 2004 were also present at T1 (27.7%) and co-offended with a total of 7202 individuals.
Regression models suggest that previous violence at time T1 is the strongest predictor of future violence (with an increase in odds never smaller than 123%), knife incidents and weapon incidents at the individual level have some predictive power (but only when no information on previous violence is considered), and the behaviour of one’s associates matters. Prior association with a violent individual and prior association with a knife-flagged individual were the two strongest network predictors, with a slightly stronger effect for knife flags. The best performing regressors are (a) individual past violence (36% of future violence cases correctly identified); (b) associates’ past violence (25%); and (c) associates’ knife involvement (14%). All regressors are characterised by a very high level of specificity in predicting who will not commit violence (80% or more).

Conclusions
Network-based indicators add to the explanation of future violence, especially prior association with a knife-flagged individual and association with a violent individual. Information about the knife involvement of associates appears to be more informative than a subject’s own prior knife involvement.
Pseudo-dimension of quantum circuits
Authors: Caro Matthias C. , Datta Ishaun 
Published: November 2020

AbstractWe characterize the expressive power of quantum circuits with the pseudo-dimension, a measure of complexity for probabilistic concept classes. We prove pseudo-dimension bounds on the output probability distributions of quantum circuits; the upper bounds are polynomial in circuit depth and number of gates. Using these bounds, we exhibit a class of circuit output states out of which at least one has exponential gate complexity of state preparation, and moreover demonstrate that quantum circuits of known polynomial size and depth are PAC-learnable.
Smart specialization strategies—insights gained from a unique European policy experiment on innovation and industrial policy design
Authors: Foray Dominique , Eichler Martin , Keller Michael 
Published: November 2020

AbstractThis paper aims to develop a coherent vision and detailed methodology of the policy approach that is evoked by the term “smart specialisation strategy” (S3), and to explore and elaborate the requirements and implications in terms of design and implementation that are consistent with that policy concept. As such, the paper addresses the issue of designing an innovation policy whose goal is the creation and development of networks of innovators in order to generate some desired structural changes within the framework of a regional economy.
A new approach to inferring basal drag and ice rheology in ice streams, with applications to West Antarctic Ice Streams
Authors: Ranganathan Meghana , Minchew Brent , Meyer Colin R. , Gudmundsson G. Hilmar 
Published: November 2020

AbstractDrag at the bed and along the lateral margins are the primary forces resisting flow in outlet glaciers. Simultaneously inferring these parameters is challenging since basal drag and ice viscosity are coupled in the momentum balance, which governs ice flow. We test the ability of adjoint-based inverse methods to infer the slipperiness coefficient in a power-law sliding law and the flow-rate parameter in the constitutive relation for ice using a regularization scheme that includes coefficients weighted by surface strain rates. Using synthetic data with spatial variations in basal drag and ice rheology comparable to those in West Antarctic Ice Streams, we show that this approach allows for more accurate inferences. We apply this method to Bindschadler and MacAyeal Ice Streams in West Antarctica. Our results show relatively soft ice in the shear margins and spatially varying basal drag, with an increase in drag with distance upstream of the grounding line punctuated by localized areas of relatively high drag. We interpret soft ice to reflect a combination of heating through viscous dissipation and changes in the crystalline structure. These results suggest that adjoint-based inverse methods can provide inferences of basal drag and ice rheology when regularization is informed by strain rates.
Chiral smoothings of knots
Authors: Livingston Charles 
Published: November 2020

AbstractCan smoothing a single crossing in a diagram for a knot convert it into a diagram of the knot's mirror image? Zeković found such a smoothing for the torus knot T(2, 5), and Moore–Vazquez proved that such smoothings do not exist for other torus knots T(2, m) with m odd and square free. The existence of such a smoothing implies that K # K bounds a Mobius band in B4. We use Casson–Gordon theory to provide new obstructions to the existence of such chiral smoothings. In particular, we remove the constraint that m be square free in the Moore–Vazquez theorem, with the exception of m = 9, which remains an open case. Heegaard Floer theory provides further obstructions; these do not give new information in the case of torus knots of the form T(2, m), but they do provide strong constraints for other families of torus knots. A more general question asks, for each pair of knots K and J, what is the minimum number of smoothings that are required to convert a diagram of K into one for J. The methods presented here can be applied to provide lower bounds on this number.