bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of cardiovascular disease risk factors and long-term outcomes in the Saudi population: Results from the Prospective Urban Rural Epidemiology study (PURE-Saudi)
Authors: Alhabib Khalid , Batais Mohammed A , Almigbal Turky H , Alshamiri Mostafa Q , Altaradi Hani , Rangarajan Sumathy , Yusuf Salim 
Published: April 2020

Abstract
Objective We report the prevalence of unhealthy lifestyle behaviors, cardiovascular disease (CVD) risk factors, and long-term outcomes within the Saudi population, stratified by age, sex, and place of residence. Methods The Prospective Urban Rural Epidemiology (PURE) study is a global cohort study including adults of 35–70 years old in 20 countries. PURE-Saudi study participants were recruited from 19 urban and 6 rural communities randomly selected from the Central province (Riyadh and Alkharj) between February 2012 and January 2015. Clinical follow-up of major CVD events and mortality is ongoing. Results The PURE-Saudi study enrolled 2047 participants (mean age, 46.5 ± 9.12 years; 43.1% women; 24.5% rural ). Overall, 69.4% had low physical activity, 49.6% obesity, 34.4% unhealthy diet, 32.1% dyslipidemia, 30.3% hypertension, 25.1% diabetes, 12.2% were current smokers, 15.4% self-reported feeling sad, 16.9% had history of stress (several periods), 6.8% had permanent stress, 0.98% had history of stroke, 0.64% had heart failure, and 2.5% had coronary heart disease (CHD). Compared to women, men were more likely to be current smokers (21% vs. 0.45%, p<0.001), have diabetes (28.2% vs. 21.3%, p<0.001), and have history of CHD (3.2% vs. 1.6%, p=0.02); while women were more likely to be obese (58.6% vs. 42.8%, p<0.001), have central obesity (70.7% vs. 32.7%, p<0.001), self-report sadness (22.7%, vs. 9.9% p<0.001), experience stress (several periods), feel permanent stress (9.9% vs. 4.5%, p<0.001), and have low education (46.6% vs. 20.2%, p<0.001). Compared to participants in urban areas, those in rural areas had higher rates of diabetes (31.1% vs. 23.3%, p<0.001), obesity (56.6% vs. 47.3%, p<0.001), and hypertension (35.5% vs. 28.6%, p=0.004); and lower rates of unhealthy diet, self-reported sadness, stress (several periods), and permanent stress. Compared to middle- and old-age individuals, younger participants more commonly reported unhealthy diet, permanent stress, and self-reporting of being sad. Conclusion PURE-Saudi, the first population cohort study in Saudi Arabia, revealed a high prevalence of CVD risk factors in the adult Saudi population, with higher rates in rural than urban areas. National public awareness programs and multi-faceted healthcare policy changes are urgently needed to reduce the burden of CVD risk and mortality.
Prenatal Diagnosis of Shone’s Syndrome by Fetal Echocardiography
Authors: Li Zhuoyan , Wu Yurong , Chen Sun 
Published: April 2020

Abstract
Background：Shone’s syndrome is a rare complex with few data published on its prenatal diagnosis, this study aimed to compare the fetal echocardiographic features between Shone’s syndrome fetuses and coarctation of the aorta (CoA) fetuses to improve the prenatal diagnosis of Shone’s syndrome and identify the mitral valve obstruction associated with the anomaly. Methods: Retrospective study was performed. Between January 2015 to December 2019, fourteen fetuses diagnosed with Shone’s syndrome were enrolled and ten were analyzed in our final study, their clinical information and echocardiographic features were compared to normal controls (N=30) and CoA cases (N=10). The main points of identification were summarized. Results: Comparing to normal controls, the PA/AO ratio was increased in both Shone’s syndrome and CoA, but Shone’s syndrome fetuses had higher PA/AO ratio than CoA fetuses (P=0.006). RV/LV and TVC/MVC ratios were only elevated in Shone’s syndrome cases (P<0.0001, P<0.0001). Analysis revealed that the TVC/MVC ratio had the best capability in predicting Shone’s syndrome and fetuses with TVC/MVC ratio over 1.290 were more likely to have Shone’s syndrome rather than CoA. Meanwhile, the main points of identification in mitral valve obstruction included (1) restrictive opening of the mitral valve, thickened leaflets, echo-enhancement of chordae tendineae and single papillary muscle in short-axis section view; (2) decreased antegrade flow and abnormal flow pattern of mitral valve in color Doppler image. Chi-square test revealed that restrictive opening of the mitral valve and single papillary muscle were the most relevant features of mitral valve obstruction. Conclusions: There are several parameters of prenatal diagnosis of Shone’s syndrome by fetal echocardiography, including (1) echocardiographic measurements: elevated RV/LV ratio, PA/AO ratio and TVC/MVC ratio, of these, the TVC/MVC ratio has the best capability in predicting Shone’s syndrome; (2) morphologic changes in short-axis section view: restrictive opening of the mitral valve and single papillary muscle are the most relevant features of Shone’s syndrome.
Palace at Żyrowa. Transformations from the 15th to Early 20th Centuries
Authors: LEGENDZIEWICZ Andrzej , MARCINÓW Aleksandra 
Published: April 2020

Abstract
The paper presents the results of research carried out in the palace at Żyrowa. The introduction discusses the architecture of the palace, analyses source references to the site and identifies successive owners. The architectural research into technology, building material and architectural detail, as well as iconographic studies were the basis for the considerations. They gave grounds for the identification of the oldest building that dates back to the Gothic period and of the scope of the Mannerist expansion that was carried out in 1631–44 by Count Melchior Ferdinand de Gaschin. The scope of the Baroque and new-style transformations in the early 20th century is also discussed. The summary emphasizes the uniqueness of the layout which stands out from other Silesian residences in terms of size, programme and architecture.
The influence of riverbank filtration on regional water resources: a case study in the Second Songhua River catchment, China
Authors: Ye Xueyan , Cui Ruijuan , Wang Lixue , Du Xinqiang 
Published: April 2020

Abstract
Riverbank filtration (RBF) of river water recharging a groundwater system has been identified as a source of water supply that guarantees the quantity of abstracted water and reduces the cost of water treatment. This paper evaluates the safe yield of groundwater in suitable areas using a numerical model of groundwater flow and discusses the influence of RBF on the temporal variation of regional hydraulic heads, groundwater flow, river flow, and groundwater–surface water interaction (GSI) under different precipitation frequencies from 20% to 95% along the Second Songhua River in Northeast China. This study shows that the potential of RBF is enormous and that the total safe yield of groundwater abstraction was 29.56 × 104 m3/day under the precipitation frequency of 95%. The direction of regional groundwater flow was not obviously changed except within the local groundwater flow field under the maximum safe yield pumping conditions. When the precipitation frequencies are higher than 75%, the direction of the GSI might be changed, and the rate of river recharge of groundwater is enhanced. The water quantity that would be captured from the river does not threaten the safety of the river ecology. It is concluded that there were no obvious adverse impacts of the large scale of RBF on regional water resources in the Second Songhua River area.
Comprehensive Bioinformatics Analysis Identifies Tumor Microenvironment and Immune-related Genes in Small Cell Lung Cancer
Authors: Song Yongchun , Sun Yanqin , Sun Tuanhe , Tang Ruixiang 
Published: April 2020

Background:
Tumor microenvironment (TME) cells play important roles in tumor
progression. Accumulating evidence show that they can be exploited to predict the
clinical outcomes and therapeutic responses of tumor. However, the role of immune
genes of TME in small cell lung cancer (SCLC) is currently unknown.

Objective:
To determine the role of immune genes in SCLC.

Methods:
We downloaded the expression profile and clinical follow-up data of SCLC
patients from Gene Expression Omnibus (GEO), and TME infiltration profile data of
158 patients using CIBERSORT. The correlation between TME phenotypes, genomic
features, and clinicopathological features of SCLC was examined. A gene signature
was constructed based on TME genes to further evaluate the relationship between
molecular subtypes of SCLC with the prognosis and clinical features.

Results:
We identified a group of genes that are highly associated with TME. Several
immune cells in TME cells were significantly correlated with SCLC prognosis
(p<0.0001). These immune cells displayed diverse immune patterns. Three molecular
subtypes of SCLC (TMEC1-3) were identified on the basis of enrichment of immune
cell components, and these subtypes showed dissimilar prognosis profiles (p=0.03).
The subtype with the best prognosis, TMEC3, was enriched with immune activation
factors such as oncogene M0, oncogene M2, T cells follicular helper, and T cells CD8
(p<0.001). The TMEC1 subtype with the worst prognosis was enriched with T cells
CD4 naive, B cells memory and Dendritic cells activated cells (p<0.001). Further
analysis showed that the TME was significantly enriched with immune checkpoint
genes, immune genes, and immune pathway genes (p<0.01). From the gene
expression data, we identified four TME-related genes, GZMB, HAVCR2, PRF1 and
TBX2, which were significantly associated with poor prognosis in both the training
set and the validation set (p<0.05). These genes may serve as markers for monitoring
tumor responses to immune checkpoint inhibitors.

Conclusion:
This study shows that TME features may serve as markers for evaluating
response of SCLC cells to immunotherapy.
Film-Forming Nanogels: Effects of Nanocarriers and Film-Forming Gel on the Sustained Release of Curcumin
Authors: Nguyen Khanh T. , Tran Phuong H.L. , Ngo Hai V. , Tran Thao T.D. 
Published: April 2020

Background:
Although film-forming hydrogels possess the advantages of both film and hydrogel
dosage forms, certain limitations still remain.

Objective:
This study aims to investigate the use of film-forming hydrogels and the effects of nanocarriers on
the sustained release of a poorly water-soluble drug, curcumin.

Methods:
The film-forming hydrogels contained either zein or polyvinylpyrrolidone as a film former, in addition
to hydroxypropyl methylcellulose, oleic acid, ethanol and water. Curcumin was encapsulated in poly(lacticco-
glycolic acid) and gelatine nanoparticles using a sonoprecipitation method. Free drug and drug-loaded
nanoparticles were later dispersed into blank hydrogels to produce the film-forming nanogels.

Results:
The results suggested that the encapsulation of curcumin in nanoparticles could reduce the drug particle
size to less than 200nm for easier diffusion and could shield curcumin from chemical interactions that limit its
topical permeability. Curcumin was more compatible with gelatine nanoparticles than with poly(lactic-coglycolic
acid) nanoparticles, and gelatine nanoparticles, in turn, were more compatible with zein than with polyvinylpyrrolidone
film-forming nanogels. Therefore, gelatine nanoparticles in zein film-forming nanogels greatly
elevated the permeability of curcumin by over five times that afforded by gelatine nanoparticles in polyvinylpyrrolidone
film-forming nanogels.

Conclusion:
This research suggested that film-forming nanogel is a promising drug delivery system for both
improved permeability and sustained topical diffusion of the extremely hydrophobic drug curcumin depending
on the compatibility between the nanocarrier and the film-forming hydrogel.
Overview of Subsynchronous Oscillation in Grid-connected Wind Farm
Authors: Pei-Zhen Xu , Yong-Geng Lu , Xi-Min Cao 
Published: April 2020

Background:
Over the past few years, the subsynchronous oscillation (SSO) caused by
the grid-connected wind farm had a bad influence on the stable operation of the system and has now
become a bottleneck factor restricting the efficient utilization of wind power. How to mitigate and
suppress the phenomenon of SSO of wind farms has become the focus of power system research.

Methods:
This paper first analyzes the SSO of different types of wind turbines, including squirrelcage
induction generator based wind turbine (SCIG-WT), permanent magnet synchronous generator-
based wind turbine (PMSG-WT), and doubly-fed induction generator based wind turbine
(DFIG-WT). Then, the mechanisms of different types of SSO are proposed with the aim to better
understand SSO in large-scale wind integrated power systems, and the main analytical methods
suitable for studying the SSO of wind farms are summarized.

Results:
On the basis of results, using additional damping control suppression methods to solve SSO
caused by the flexible power transmission devices and the wind turbine converter is recommended.

Conclusion:
The current development direction of the SSO of large-scale wind farm grid-connected
systems is summarized and the current challenges and recommendations for future research and development
are discussed.
En torno a la existencia de una estética nietzscheana
Authors: Puelles Romero Luis 
Published: April 2020

RESUMENEstas páginas, dedicadas al libro de Luis de Santiago Guervós "Arte y poder. Arpoximación a la estética de Nietzsche" (Madrid, Trotta, 2004), tratan de indagar en las condiciones de posibilidad que permiten postular la existencia de una estética nietzscheana. Para ello, además de comentar el libro que las origina, se observa en ellas las confrontación de la aportación nietzscheana sobre lo artístico con la tradición estética kantiana.PALABRAS CLAVENIETZSCHE-ESTÉTICA-ARTEABSTRACTThis pages, dedicated to the book of Luis de Santiago Guervós "Arte y poder. Arpoximación a la estética de Nietzsche" (Madrid, Trotta, 2004), try to investigate in the conditions of posibility that permit to postulate the existence of one nietzschean aesthetic. For that, furthermore of dicuss the book that is the origin of it, we remark here the confrontation between Nietzsche´s contribution to the artistic and kantian tradition aesthetic.KEYWORDSNIETZSCHE-AESTHETICS-ART
La crítica moral y religiosa en la obra de Cyrano de Bergerac
Authors: Gómez Rodríguez Carlos 
Published: April 2020

RESUMENEl presente artículo examina el pensamiento de Savinien de Cyrano de Bergerac (1619 - 1655) tal y como se expresa en dos de sus obras fundamentales: L´autre Monde ou les états et empires de la lune (publicada en 1657, dos años después de su muerte) e Histoire comique des états et empires du Soleil (1662). En ellas expresa de forma mordaz y extremadamente crítica sus posiciones cosmológicas y filosóficas. Este componente polémico se extiende en Cyrano ya no sólo hacia una cosmología tradicionalmente aliada con el Cristianismo, sino al antropocentrismo cristiano y a importantísimos dogmas teológicos, como la cristología, la providencia o la inmortalidad del alma.PALABRAS CLAVEANTROPOCENTRISMO-PLURALIDAD DE MUNDOS-MATERIALISMO-INMORTALIDADABSTRACTThis paper examines Savinien de Cyrano de Bergerac (1619 - 1655) as they are expresed in his major Works: L´autre Monde ou les états et empires de la lune (published in 1657, two years after his death) and Histoire comique des états et empires du Soleil (1662). In these books he expreses his ideas about cosmology and philosophy with extreme criticism. This polemics but to Christian antropocentrism and to very important theological dogma such as christology, providentialism or the soul´s inmortality.KEYWORDSANTROPOCENTRISM-PLURALITY OF WORLDS-MATERIALISM-INMORTALITY
Control vertical o vacío de sentido: relevancia del concepto de mundo para la definición de la ética política. La polémica de Strauss y Voegelin con Max Webe
Authors: Franzé Javier 
Published: April 2020

RESUMENEste artículo busca abordar una cuestión que parece cobrar relevancia política en sociedades postmodernas y secularizadas: las implicaciones que para la ética política puede tener el considerar el mundo como un lugar vacío de sentido inherente o, por el contrario, como una realidad moral. Para ello se recupera la crítica que autores como Leo Strauss y Eric Voegelin, apoyados en una visión clásica de la política que reunía verdad y política, hicieron de Max Weber, cuya reflexión partía de la imposibilidad de fundamentar objetivamente los valores y, por tanto, de conciliar verdad y política. La cuestión que se abre es si una perspectiva que, como la clásica, busca reunir verdad y política, no puede resultar paradójicamente menos consistente para dar cuenta de la especificidad de la ética política que otra que, como la weberiana, da por sentado la imposibilidad de tal reunión.PALABRAS CLAVEPOLÍTICA, VERDAD, ÉTICA, VALORES, VIOLENCIA, WEBER, STRAUSS, VOEGELINABSTRACTThis article deals with an issue that seems to become relevant in postmodern and secularized societies: the implications for political ethics of considering the world as a place without any essential and inherent meaning or, on the contrary, as a moral reality. In order to do this, we recover the criticism made by authors like Leo Strauss and Eric Voegelin –based on a classical concept of politics, joining truth and politics together–of Max Weber’s point of view, starting from the impossibility of objectively founding values and thus, of reconciling truth and politics. The question that arises is, if one perspective looks to join truth and politics together, as does the classical one, it cannot be paradoxically less able to portray the particularity of political ethics than another, like the Weberian one, which supposes the impossibility of the union of truth and politics.KEY WORDSPOLITICS, TRUTH, ETHICS, VALUES, VIOLENCE, WEBER, STRAUSS, VOEGELIN.
Cultura y traducción
Authors: Martínez García Adela 
Published: April 2020

RESUMENEn este artículo vamos a tratar la complejidad de la noción de cultura. La cultura ha sido tratada por muchos movimientos y por muchos pensadores. Nos centraremos en algunos de ellos y sobre todo en García Morente. La cultura es el ámbito en que se mueve todo y de modo especial el lenguaje; el marco ineludible y el mayor reto de la traducción.PALABRAS CLAVECULTURA – CIVILIZACION – TRADUCCION ABSTRACTThe complex notion of culture is the main subject of this article. It has been studied by many movements and scholars, notably by García Morente, whose thesis on culture will be discussed. Everything, as well as language, in its own special way, comes under the scope of culture. Thus culture bound lexical items and concepts being the greatest challenge for the translator.KEYWORDSCULTURE – CIVILIZATION - TRANSLATION
Pluralismo cultural y pertenencia comunitaria (Sobre una acepción de cultura)
Authors: Toscano Méndez Manuel 
Published: April 2020

RESUMENEste trabajo se interesa por una acepción de cultura que ha cobrado una indudable importancia en los últimos timepos y que tiene que ver con la definición de identidades y delimitación de fronteras entr grupos. NUestro propósito es no tomar dicha acepción como algo obvio y para ello intentamos recuperar su historicidad refiriéndonos a la oposición entre cultura y civilización que se traza a finales del s. XVIII en Alemania. Lejos de ser un término neutro, el sesgo y las implicaciones filosóficas de cultura nos remiten a lo que Berlin ha denominado la contra-ilustración. PALABRAS CLAVECULTURA-CIVILIZACION-CONTRA-INLUSTRACION-PLURALISMOABSTRACTTHis paper focuses on one respect of cultura that has drawn an unquestionable attention lately. This has to do with the definition of identities and with the drawing of boundaries among groups. Our aim is not to consider it as self-evident. To that end, we try to retrieve its historicity by reerring to the oposition of culture and civiltiation advanced in Germany by the end of the XVIIIth century. Far from being a neutral term, the feature and the philosophic implications of culture lead us to what Berlin has called the counter-Enlightement.KEYWORDSCULTURE-CIVILITATION-COUNTER-ENLIGHTEMENT-PLURALISM
Análise da variabilidade climática do município de Garanhuns, Pernambuco – Brasil (Analysis of climate variability in the city of Garanhuns, Pernambuco - Brazil)
Authors: Barbosa Vanessa Vasconcelos , De Souza Weronica Meira , Galvíncio Josiclêda Dominicano , Costa Valéria Sandra de Oliveira 
Published: April 2020

A investigação das tendências climáticas e das possíveis mudanças do comportamento climático associado aos registros de alterações climáticas globais auxilia na redução da vulnerabilidade às oscilações do regime de precipitação. Este trabalho teve como objetivo avaliar as tendências climáticas da precipitação pluviométrica e dos índices de extremos climáticos no município de Garanhuns, Pernambuco - Brasil. Foram utilizados dados diários de precipitação no período de 1961 a 2014, fornecidos pelo Instituto Nacional de Meteorologia-INMET. Para atingir o objetivo proposto foi utilizado o software Climap para analisar a tendência da precipitação e dos índices de extremos climáticos, assim como o teste sequencial de Mann-Kendall para verificar o ano aproximado em que as tendências tiveram início. Os resultados indicaram que não houve tendências nas séries dos totais anuais e nos índices de extremos de precipitação. Porém, constatou-se uma possível alteração na série de precipitação total anual a partir de 2003, e a predominância da alta variabilidade anual da precipitação pluviométrica na região. ABSTRACT The investigation of climate trends and possible changes in climate behavior associated with records of global climate change helps in reducing vulnerability to fluctuations in precipitation regime . This study aimed to assess climate trends of rainfall and climatic extremes indices in the city of Garanhuns , Pernambuco – Brazil. Daily rainfall data were used from 1961 to 2014 , provided by the National Institute of Meteorology - INMET . To achieve purpose we used the CLIMAP software to analyze the trend in rainfall and indices of extremes climatic, as well as the sequential Mann- Kendall to check the trend. The results indicated that there was no trend in the series of indexes of extremes climatic and the total annual precipitation. However , there was a possible change in annual rainfall from 2003 , and high annual variability of rainfall in the region. Keywords: climate, rainfall, Climap.
Розвиток трудового потенціалу та потенціалу підприємства як фактори конкурентоспроможності підприємства
Authors: Чернявська Є.І. , Маслош О.В. 
Published: April 2020

Стаття присвячена аналізу трудового потенціалу та потенціалу підприємства як факторів його конкурентоспроможності. В загальному плані конкурентоспроможність підприємства – це його здатність виготовляти продукцію, що користується попитом у споживачів, і отримувати на цій підставі прибуток. Після ІІ світової війни частина традиційних корпорацій в результаті згортання економічного простору капіталу та розгортання НТП опинилася в кризовому стані. Обґрунтовано, що принципове удосконалення виробничих відносин зумовило розвиток трудового потенціалу. Нові знання, кваліфікація, партнерський характер трудових відносин перетворили робочу силу на людський капітал. Реструктуризація корпорацій, реінжиніринг бізнес процесів надави поштовх розвитку потенціалу підприємства. Економіка в цілому, корпорації – зокрема перейшли на модель інтенсивного розвитку, що поставило в практичну площину можливості забезпечувати відповідний рівень конкурентоспроможності підприємств.