bluuebunny/crossref_metadata_2025_split huggingface dataset:
Students’ entrepreneurial competence formation approaches in the human health background Studying
Authors: Kabatska O. 
Published: August 2020

The article presents the students‘ entrepreneurial competence formation approaches of higher education. The importance of students acquiring health-preserving competence in the process of education at V. N. Karazin Kharkiv National University. Educational and professional programs –―Secondary education (Biology and human health)‖ and ―Secondary education (Human health)‖ were analyzed in order to identify the specifics of the formation of health competence.
The value of the foundations of the students‘ entrepreneurial competence formation who master the knowledge, skills and abilities in the basics of health for their implementation in professional activities, taking into account the requirements of Ukraine as a European state.
According to the results of the study of scientific research, it has been revealed that the students‘ entrepreneurial competence formation is paid attention only in the process of education of future specialists in international economic relations, business, etc. It has been established that the study of the basics of entrepreneurial activity of students is aimed at the formation of their competencies for work in positions of managers, employees in government agencies and institutions, and so on.
It was also investigated that the students‘ entrepreneurial competence formation who study the basics of health is possible if they study interdisciplinary disciplines on relevant topics, due to their own choice in this area and even in a distance format. It has been noted that the Center for e-learning of V. N. Karazin Kharkiv National University provides distance education for students and anyone wishing to gain knowledge in various fields. It was also revealed that teachers under the guidance of employees of this center create distance e-courses in the Moodle system, pass the appropriate certification of their intellectual work and manage the student education via the Internet in a comfortable environment for all participants in the educational process.
As a result, it is noted that the preparation of highly qualified specialists, possessing the health and entrepreneurial competencies will ensure the preservation and strengthening the health of the population of Ukraine, promote the best realization of acquired knowledge, skills and abilities of students even in difficult conditions of future professional self-realization.
REFRACTORY FUNGAL VAGINITIS TREATED BY TOPICAL AMPHOTERICIN B. Review
Authors: Falah Hasan Obayes AL-Khikani  
Published: August 2020

Vaginitis is a common problem for women regarding a worldwide health challenge with many side effects. Vaginitis is among the most visiting to gynecology clinics. About 75% of all reproductive women had at least one fungal vaginitis infection in their life, and more than 40% will have two or more than two. Candida spp is the most prevalent in fungal vaginitis, while reports for unusual fungi were observed as mucor spp.
Amphotericin B (AmB) belongs to the polyene group has a wide spectrum in vitro and in vivo antifungal activity. All of the known available formulas of AmB are administrated via intravenous injection to treat severe systemic fungal infections, while the development of the topical formula of AmB is still under preliminary development including topical vaginal AmB.
Due to the revealing of antimicrobial-resistant fungi in recent years, this study explains the role of topical AmB in treating refractory fungi vaginitis that may not a response to other drugs reported in many cases that may help researchers to develop new effective formula of AmB regarding fungal vaginitis.
CHANGES OF COGNITIVE FUNCTION IN PATIENTS WITH HYPERTENSION WITH CONCOMITANT DIABETES MELLITUS TYPE 2
Authors: Netiazhenko V.Z. , Malchevska T.I. , Plenova O.N. , Potaskalova V.S. , Taranchuk V.V. 
Published: August 2020

Relevance. Till now there is no clear clinical trial understanding of the relationship between hypertension (AH) and the patient's cognitive function.
Objective: the investigation of changes in cognitive function in patients with hypertension with concomitant type 2 diabetes mellitus (DM2).
Materials and methods. 215 people were examined: Group I (n = 131) – stage II hypertensive disease (HD); Group II (n = 46) – HD, combined with diabetes mellitus2; Group III, control (n = 38) – without a diagnosis of HD and diabetes mellitus2. All examined blood pressure (BP), echocardiogram. Clinical complaints, anamnestic data, and neuropsychiatric testing data were used to diagnose moderate cognitive impairment (MCI). Used modified diagnostic criteria J. Touchon, R. Petersen. To assess cognitive function used: Short scale of assessment of mental state (Mini-Mental State Examination - MMSE); Frontal Assessment Battery (FAB); clock drawing test; test for literal and categorical associations; Schulte tables; the Global Deterioration Scale (GDS) and the Clinical Dementia Rating (CDR).
Result. In patients with HD, the most significant risk factors for moderate cognitive impairment are hypercholesterolemia and overweight (with OR 1.8), obesity (OR 1.6), the presence of concomitant diabetes mellitus2, which, especially in overweight, significantly impairs cognitive function ( OR 2.56). Deterioration of cognitive function correlates with the duration of HD, cholesterol levels. Concomitant diabetes mellitus2 in patients with HD creates a statistically significant additional negative effect on the results of cognitive function. In patients with HD with a distorted daily blood pressure profile, the neurodynamic component of cognitive function is first of all affected - conceptualization, repetition, the reaction of choice. The relationship between cognitive function and daily monitoring of blood pressure often have a U-shaped relationship, where the maximum indicators of cognitive function are at the level of the optimal recommended blood pressure figures (130-139 mm Hg for SBP, and 75-85 mm Hg for DBP, and the daily index within 10%).
Conclusions. There is a dependence on changes in cognitive function on the presence of risk factors and signs of subclinical damage to target organs. The nonlinear U-shaped character of the relationship between the average daily, average night, and average daily blood pressure and the results of screening tests and scales for assessing cognitive function are shown.
EARLY COMPLEX REHABILITATION TREATMENT OF PATIENTS WITH FRACTURE OF DISTAL METAEPIPHYSIS OF THE RADIUS
Authors: Rushai A.K. , Bogdanova L.V. , Klymovytskyy F.V. , Lisunov S.V. 
Published: August 2020

Relevance. Fractures of the distal metaepiphysis of the radial bone among all fractures range from 11% to 30%. Unsatisfactory results of treatment in patients over 70 years old are found in 44% of cases. Timely and adequate rehabilitation treatment is important for obtaining good results in the treatment of such patients.
Objective: to improve the results of the treatment of patients with fractures of the distal metaepiphysis of the radial bone based on early comprehensive individual rehabilitation treatment.
Materials and methods. 97 patients with displaced fractures of the distal metaepiphysis of the radius were observed. Among them, 67 are women (69.1%), over 50 years old – 64 (66%). Used conservative treatment with a sparing technique of one-stage reduction. Upon completion of the correction, according to the indications, measures were prescribed for the prevention of neurodystrophic syndrome, depending on the likelihood of its development (according to the temperature gradient of the fingers of the extremities) in the form of drug therapy. Massage, kinesiotherapy, and physiotherapy began on the second day. The pain intensity was determined using a visual analog scale. The nature of pain was determined by the DN4 questionnaire (questionnaire for the diagnosis of neuropathic pain). For subjective unified assessment of hand function in the long term after a hand injury, I used a specific questionnaire DASH (Disability of the Arm, Shoulder and Hand Outcome Measure) – a questionnaire of outcomes and disability of the hand and hand.
Results. Rehabilitation treatment at admission and at the early outpatient stage was complex, individual, taking into account the periods of illness. The debris correction was painless, low-traumatic, rational fixing bandages were used. The volume of drug therapy was determined by the value of the temperature gradient of the fingers.
Conclusion. The proposed method for the rehabilitation of patients with fractures of the distal metaepiphysis of the radius is highly effective: good and satisfactory (according to the DASH scale) results were obtained in 97.8% of cases, unsatisfactory – in 2.2%.
FORENSIC MEDICAL AND LEGAL ASPECTS OF THE PROVISION OF MEDICAL CARE IN OBSTETRICS AND GYNECOLOGY
Authors: Pletenetska A.O. 
Published: August 2020

Relevance. Sometimes statistics on medical errors are hushed up, and information about individual incidents becomes known thanks to the media.
Objective: to identify the most common obstetric-gynecological profile defects and their causes by analyzing the data of the State Statistics Service on maternal and infant mortality during pregnancy, childbirth, and the postpartum period and compare it with the forensic analysis of obstetric-gynecological profile medical care.
Materials and methods. 625 cases were analyzed according to the State Statistics Service on maternal and infant mortality during pregnancy, childbirth and the postpartum period, court sentences in criminal cases under Articles 139 and 140 of the Criminal Code of Ukraine, according to the Unified State Register of Court Decisions of Ukraine since 2009 in 2019, as well as data from forensic medical examination commissions on “medicinal matters” for 2013-2019 performed by the State Institution “Main Bureau of Forensic Medical Examination of the Ministry of Health of Ukraine”, including cases of previous departmental audits by the commissions of the Health Administration. The data obtained were subjected to statistical processing by standard methods of descriptive statistics.
Results. In these 255 examinations, defects in the provision of medical care were found by expert commissions in 186 cases, which amounted to 72.9%. Moreover, of these "defective cases", 62.9% (117 cases) were in a direct causal relationship with an unfavorable outcome; 35.5% (6 cases) - in some deficiencies that did not have a causal relationship with the onset of fetal death. In 3 cases of examinations in gynecology, there were contradictions in the entries in the medical documentation, they did not allow assessing the quality of medical care and the relationship with the consequences. At the pre-hospital stage (in the clinic), defects were allowed in 65.5%, and at the hospital - in 72.8%. In the presence of departmental inspections in 23%, there was a complete coincidence of the results of the conclusions of the commissions of the bureau of forensic medical examination and medical examination, and only in cases of significant defects in direct causal connection with the consequences. At the same time, when analyzing 53 court sentences according to the register of court decisions, it turned out that 13 of them related to the obstetric and gynecological profile, and 12 of them were indictment. In all cases, the source of evidence in cases was exclusively the “Expert Conclusions”.
Conclusions. It was found that forensic medical examinations for the provision of obstetric and gynecological medical care occupy a leading place in the overall structure of commission examinations in “medical matters”, in the vast majority of examinations, defects in the provision of medical care were found that were in direct causal connection with an unfavorable outcome.
DIAGNOSIS OF ALCOHOL INTOXICATION IN VICTIMS OF EMERGENCIES
Authors: Babkina О.P. , Matyukhin D.О. , Ushko I.А. 
Published: August 2020

Relevance. In the case of death from injury, the question of whether the victim was intoxicated and to what extent, as the presence of alcohol intoxication could have affected the thanatogenesis of death is important. A reliable method of determining the concentration of ethanol in the body is its study in the blood, urine, and cerebrospinal fluid. But in extreme conditions, in large-scale disasters, during military conflicts, there may be difficulties in the selection, storage, transportation, and research of biological fluids. Therefore, the search for reliable non-invasive rapid methods is relevant.
The objective is the development of a set of criteria for improving the accuracy of detecting the presence of ethanol and determining its amount in deaths due to trauma in emergencies by non-invasive rapid methods.
Materials and methods. Review of scientific publications in international electronic scientometric databases PubMed, Embase, and Scopus by keywords. Search depth - 10 years (2008-2018). Comparison of literature data with the results of own research on the possibility of diagnosing alcohol intoxication to detect the presence and determination of ethanol in biological fluids (saliva, blood, urine) of persons who died and died in emergencies by indicative and evidentiary methods.
Results. The possibility of using the non-invasive express method (indicator test strips) as a guide to detecting the presence and quantification of ethanol in the saliva of deaths and deaths from injuries in emergencies, conflicts, in the absence of the necessary conditions for blood storage and urine (lack of power supply, the impossibility of freezing objects, storage, destruction of objects during transportation, etc.) was described. It is proved that the average result of the quantitative content of ethanol in blood and urine, found in the evidence-based method of research (gas-liquid chromatography), coincides and confirms the result obtained by us in conducting a non-invasive rapid method using indicator test strips. In the course of the conducted researches, the conformity concerning objectivity and correctness of detection of the presence and quantitative content of ethyl alcohol with the use of indicator test strips which is confirmed by researches of blood, urine by evidential methods (gas-liquid chromatography) is proved.
Conclusion. A non-invasive rapid method (indicator test strips) can be used as a guide to detect the presence of ethyl alcohol and determine its quantitative content in the saliva of the dead and deceased, with subsequent confirmation by evidence-based methods of research (gas-liquid chromatography) of blood, urine.
INDOMETHACIN & SARS-COV-2: PROSPECTS FOR CLINICAL MANAGEMENT OF THE INFLAMMATORY STATE. Review
Authors: Kodidala S.R. , Sorout J. , Jayachandra S. , Narapogu V. 
Published: August 2020

Actuality. Severe acute respiratory syndrome- (SARS) is a pandemic (called as SARS-CoV-2 or COVID-19), severely affected by transmission and fatal disease caused by unknown coronavirus family of RNA virus (SARS-COV). The phenotype can range from asymptomatic to fulminate cytokine storm which leads to multiorgan failure resulting in death. Still, the world is eagerly waiting for antiviral drugs to stop the coronavirus infection. Previous studies found that indomethacin had the ability to inhibit the RNA and DNA virus replication. Objectives. Discuss the possibility of clinical treatment of inflammation caused by SARS-COV-2 with indomethacin. Materials and methods. Analysis of scientific publications in the international electronic scientometric database PubMed by keywords for the period 1991-2020. Comparison with clinical cases. Results. Interleukins, Interferons, and metabolites formed by the enzyme cyclooxygenase (COX 1/COX 2) are active against some RNA viruses. Experts have divided the SARS infection into three phases (phase-1, 2, 3) based on the severity of the infection. In phase-3 there was “cytokine storm” due to exuberant inflammation observed which can damage organs and even fatal. We investigated the effect of indomethacin on the COX inhibitor on coronavirus replication and cytokine storm in reducing the hyperinflammatory state. Indomethacin is a potent inhibitor of SARS CoV-2. Conclusion. Indomethacin can be considered safe and effective for the prevention and treatment of coronavirus infection also antiviral activity.
Observación de la ficción televisiva en ocho países iberoamericanos
Authors: Orozco Gómez Guillermo , Vassallo de Lopes María Immacolata 
Published: August 2020

En este texto se reportan comparativa e históricamente los resultados de la observación de la programación televisiva de ficción en ocho países iberoamericanos durante 2008. Se aprecian cambios significativos en la producción, en la transmisión y en la recepción de los diversificados formatos que presenta este género televisivo. La telenovela sigue siendo el formato más popular entre las audiencias, el que llena el prime timenacional y sirve, a la vez, de escaparate a una creciente naturalización de la publicidad y la política.
Diversification of Making Chicken Meatballs with Sweet Potato Substitution (Ipomoea batatas L) by Different Concentrations
Authors: Aprita Ika Rezvani , Irhami Irhami , Anwar Chairil , Salima Reza 
Published: August 2020

ABSTRACTMeatballs are food products in the form of spheres obtained from a mixture of livestock meat (meat content not less than 50% of the total mixture) with the process of meat grinding, doung making, meatballs making and meatballs printing. The purpose of this study was to determine how the effect yellow sweet potato addition improved the quality of meatballs chicken. This study used a Completely Randomized Design (CRD) with three levels of yellow sweet potato 65, 75 and 85% and six replications. The results showed that the addition of yellow sweet potato significantly influenced the value of beta-carotene and flavor. Meatballs with the addition of 65% yellow sweet potato based on organoleptic test obtained the best quality based on color ie 3.25 (acceptance level rather like), taste 3.43 (acceptance level rather like), texture 3.20 (acceptance level rather like) and at the concentration of 75% obtained the best quality only at the aroma that is 3.2 (acceptance level rather like).
Time-dependent variations in urine volume and serum creatinine levels during post-operative hospital stay period after renal transplantation: experience in a tertiary care hospital of Bangladesh
Authors: Khoda Mohammad Mehfuz E , Rahim Muhammad Abdur , Shimu Ishrat Jahan , Hossain Md Golzar , Sharif Ahmed , Mansur Md Abul 
Published: August 2020

Background: Kidney transplantation is the preferred treatment for end stage kidney disease (ESKD). Early post kidney transplant urine volume may correlate with favorable allograft survival. The aim of the present study was to examine the potential changes in urine volume with serum creatinine during post-operative hospital stay period after renal transplantation.
Methods: We retrospectively reviewed the medical records of patients who had undergone kidney transplantation at Bangladesh Institute of Research and Rehabilitation of Diabetes, Endocrine and Metabolic Disorders (BIRDEM) General Hospital, Dhaka, Bangladesh between November 2004 and February 2019. Total patients were 133. Twenty four hour urine volume and serum creatinine levels were measured on day 1, day 5 and day 10 after operation. Correlation was performed by using Pearson correlation test.
Results: The mean age of the renal allograft recipients was 36.7±10.3 years with male to female ratio of 2.7:1. The mean 24 hours urine volume on Day 1, Day 5 and Day 10 were 8990±5377 ml, 4860±2074 ml and 4485±1722 ml respectively and serum creatinine levels were 3.5±1.5 mg/dl, 1.6±1.2 mg/dl and 1.5±1.3 mg/dl respectively. Negative correlation were found between the Day 1, Day 5 and Day 10 serum creatinine and the urine volume (r=0.366, 0.507, 0.365 respectively) with significant p values (<0.01) in each group.
Conclusion: Although urine volume showed considerable variation in early post renal transplantation, it stabilized by the course of time, which was also negatively correlated with the serum creatinine levels.
Birdem Med J 2020; 10(3): 149-151
A comparative study on clinical features and outcomes of acute pancreatitis between diabetic and non-diabetic hospitalized patients
Authors: Hossain Mostaque , Hosen Zubaer , Kabir Isabela , Karim Md Rezaul , Rahim Muhammad Abdur , Uddin Khwaja Nazim 
Published: August 2020

Background: Pancreatitis is a serious disorder of pancreas. This study was designed to investigate the clinical features and outcomes of the hospitalized patients with acute pancreatitis (AP) with or without diabetic mellitus (DM).
Methods: A total of 90 adult hospitalized patients with AP diagnosed in three different tertiary hospitals were evaluated for inclusion in prospective study on clinical, laboratory and outcome parameters. After exclusion according to exclusion criteria, 68 patients were enrolled finally, and out of 68 patients 34 were diabetic with AP from BIRDEM and 34 AP patients were non-diabetic from Dhaka Medical College and BSMMU.
Results: The major clinical features, laboratory markers were significantly (p<0.05) higher whereas serum albumin levels was significantly (p<0.05) lower in diabetic AP group as compared to the non-diabetic AP group. DM was associated with severe form of AP compared to the non-diabetic group (p<0.05).
Conclusions: The results of the present study suggest that DM increases the disease severity of AP. Therefore, clinicians should pay more attention in the treatment and management of acute pancreatitis if the patients have DM.
Birdem Med J 2020; 10(3): 172-181
Clinical and laboratory profile of dengue fever in hospitalized children in a tertiary care hospital in Bangladesh
Authors: Khan Shareen , Baki Md Abdul , Ahmed Tasnima , Mollah Md Abid Hossain 
Published: August 2020

Background: Dengue is a major health problem affecting Bangladesh. The number of cases have increased over the last few years with a large number of population being children. However data regarding dengue among children is limited. The objectives of this study were to see the clinical and laboratory profile of dengue fever (DF) in children and their outcome.
Methods: This cross - sectional study was carried out in the department of Paediatrics, BIRDEM General Hospital 2 from June 2018 to August 2019. Three hundred and ten confirmed dengue cases were enrolled in the study. Their clinical profile and laboratory findings including haemoglobin (Hb%), haematocrit (Hct), total count of white blood cells (TC), differential count of white blood cells ( DC), platelet count (PC), serum alanine aminotransferase ( S. ALT), serum aspartate aminotransaminase (S. AST), prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (APTT) were documented. Comparison was made between the clinical and laboratory profile with severity of dengue.
Results: One hundred and ninety eight (63.9%) had dengue fever, 58(18.7%) had dengue haemorrhagic fever (DHF I, II) and 54 ( 17.4 %) had dengue shock syndrome ( DHF III and IV). All the patients had fever, vomiting was present in 40%, ascites and skin rash in 21 %, pleural effusion 20%, abdominal pain 14% and 12.2% came with shock.Thrombocytopenia, raised hct, raised liver enzymes and abnormal coagulation profile were more common in dengue haemorrhagic fever when compared to patients with dengue fever.
Conclusion: Gastrointestinal features like vomiting, ascites ,abdonminal pain were common presentations. Thrombocytopenia, raised hct, raised liver enzymes, abnormal coagulation profile were more common in dengue haemorrhagic fever.
Birdem Med J 2020; 10(3): 200-203