bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluación del ensayo enhaced estradiol (eE2) en el analizador Atellica IM 1600 de Siemens
Authors: Macias-Muñoz Laura , Filella Xavier , Augé Josep Maria , Hanzu Felicia A. , Morales-Ruiz Manuel , Bedini Josep Lluis , Jiménez Wladimiro , Casals Gregori 
Published: March 2020

Resumen

Introducción
El estradiol en suero (E2) se emplea para el diagnóstico y/o seguimiento de una amplia variedad de patologías. El objeto del presente estudio es evaluar el ensayo enhanced estradiol (eE2) de Siemens en el sistema Atellica IM 1600 (Siemens Healthineers) y llevar a cabo una comparación de muestras con el analizador Advia Centaur XP (Siemens Healthineers).

Métodos
Los coeficientes de variación (CV) intradía e interdía se evaluaron utilizando pools de muestras séricas y materiales de control de calidad. El límite de cuantificación se determinó mediante el empleo de seis muestras de suero con concentraciones decrecientes de E2. La linealidad fue evaluada a través del análisis de dos muestras diferentes de suero. La exactitud se determinó midiendo tres materiales de referencia certificados. Comparamos los sistemas Atellica y Centaur XP con el método de regresión de Passing–Bablok y el gráfico de Bland–Altman utilizando 119 muestras de suero con concentraciones de entre 45 y 10.059 pmol/L.

Resultados
La imprecisión intradía e interdía fue <6,6%. La exactitud fue <6,0% en todos los valores de E2 evaluados excepto para la concentración de 114 pmol/L (22%). El análisis del límite de cuantificación resultó en una imprecisión interdía <20%. Se observó una alta correlación entre los valores de dilución de E2 observados y esperados (r=0,99), con un porcentaje de recuperación que oscila entre el 77 y el 93%. El estudio comparativo mostró un buen nivel de concordancia, sin hallarse un sesgo significativo.

Conclusiones
Este estudio indica que el ensayo eE2 tiene una imprecisión y una exactitud aceptables, mostrando una buena correlación con el sistema Centaur XP.
Protection Zones in Periodic-Parabolic Problems
Authors: López-Gómez Julián 
Published: March 2020

Abstract
This paper characterizes whether or not

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≡

lim

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↑
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+

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)

,
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,

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\Sigma_{\infty}\equiv\lim_{\lambda\uparrow\infty}\sigma[\mathcal{P}+\lambda m(% x,t),\mathfrak{B},Q_{T}]

is finite, where

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0

{m\gneq 0}

is T-periodic and

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⁢

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+

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{\sigma[\mathcal{P}+\lambda m(x,t),\mathfrak{B},Q_{T}]}

stands for the principal eigenvalue of the parabolic operator

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+

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⁢
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,
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, on

∂
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×

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. Then this result is applied to discuss the nature of the territorial refuges in periodic competitive environments.
Put Dialectics into the Machine: Protection against Automatic-decision-making through a Deeper Understanding of Contestability by Design
Authors: Sarra Claudio 
Published: March 2020

Abstract
This paper endorses the idea that the right to contest provided for by art. 22, § 3 GDPR, actually is the apex of a progressive set of tools the data subject has at his disposal to cope with automatic decisions and it should work as an architectural principle to create contestable systems. But in order to achieve that important role, it cannot be reduce to the right of human intervention, also provided for by art.22, § 3, nor to a generic opposition to the outcome of the automatic processing. Thus, drawing from a thorough analysis of the relationships among the rights included in art. 22, § 3 GDPR as well as from the juridical proper meaning of “contestatio”, it is concluded that the right to contest has its own proper nature as a hybrid substantial-processual right that is able to give concrete shape to all the other rights indicated in art. 22, § 3, included the much discussed right to explanation.
Ultrasensitive graphene position-sensitive detector induced by synergistic effects of charge injection and interfacial gating
Authors: Wang Wenhui , Du Ruxia , Sun Litao , Chen Wei , Lu Junpeng , Ni Zhenhua 
Published: March 2020

Abstract
Position-sensitive detectors (PSDs) are essential components to the realization of displacement and vibration detection, optical remote control, robot vision, etc. The light sensitivity of PSDs is a crucial parameter, which determines the operating range or detection accuracy of the measurement systems. Here, we devise an ultrasensitive PSD based on graphene/Si hybrid structure by using the synergistic effect of charge injection and interfacial gating. Photogenerated carriers in Si are separated by the built-in electric field at the surface. Holes diffuse laterally in inversion layer and then inject into graphene to form photoresponse. Meanwhile, the electrons in bulk Si that move to the area under graphene cause a gating effect, thus introducing a high gain. With the benefit of synergistic effect, the detection limit power of our device can be pushed to pW level, which is reduced by two orders of magnitude compared to previously reported graphene based PSD. Furthermore, even for infrared light of 1064 nm, the PSD still retains position sensitivity to 1 nW weak light, as well as fast response speed at the μs level. This work provides the potential of graphene as a promising material for ultraweak light position sensitive detection.
Machine Learning Techniques for Classifying the Mutagenic Origins of Point Mutations
Authors: Zhu Yicheng , Ong Cheng Soon , Huttley Gavin A 
Published: March 2020

Abstract
Mutations contribute significantly to developing diversity in biological capabilities. Mutagenesis is an adaptive feature of normal development, e.g. generating diversity in immune cells...
There is increasing interest in developing diagnostics that discriminate individual mutagenic mechanisms in a range of applications that include identifying population-specific mutagenesis and resolving distinct mutation signatures in cancer samples. Analyses for these applications assume that mutagenic mechanisms have a distinct relationship with neighboring bases that allows them to be distinguished. Direct support for this assumption is limited to a small number of simple cases, e.g., CpG hypermutability. We have evaluated whether the mechanistic origin of a point mutation can be resolved using only sequence context for a more complicated case. We contrasted single nucleotide variants originating from the multitude of mutagenic processes that normally operate in the mouse germline with those induced by the potent mutagen N-ethyl-N-nitrosourea (ENU). The considerable overlap in the mutation spectra of these two samples make this a challenging problem. Employing a new, robust log-linear modeling method, we demonstrate that neighboring bases contain information regarding point mutation direction that differs between the ENU-induced and spontaneous mutation variant classes. A logistic regression classifier exhibited strong performance at discriminating between the different mutation classes. Concordance between the feature set of the best classifier and information content analyses suggest our results can be generalized to other mutation classification problems. We conclude that machine learning can be used to build a practical classification tool to identify the mutation mechanism for individual genetic variants. Software implementing our approach is freely available under an open-source license.
Perioperative Transfusions and Venous Thromboembolism
Authors: Goel Ruchika , Josephson Cassandra D. , Patel Eshan U. , Petersen Molly R. , Makhani Sarah , Frank Steven M. , Ness Paul M. , Bloch Evan M. , Gehrie Eric A. , Lokhandwala Parvez M. , Nellis Marianne M. , Karam Oliver , Shaz Beth H. , Patel Ravi M. , Tobian Aaron A.R. 
Published: March 2020

BACKGROUND AND OBJECTIVES:Annual incidence of venous thromboembolism (VTE) including postoperative VTE in hospitalized children is rising significantly. A growing body of evidence supports the role of red blood cells (RBCs) in pathologic thrombosis. In this study, we examined the association of perioperative RBC transfusion with postoperative VTE in pediatric patients.METHODS:The pediatric databases of the American College of Surgeons’ National Surgical Quality Improvement Project from 2012 to 2017 were used. Multivariable logistic regression was used to examine the association between perioperative RBC transfusion status and the development of new or progressive VTE within 30 days of surgery. The analyses were age stratified, as follows: neonates (≤28 days), infants (&gt;28 days and &lt;1 year), and children (≥1 year).RESULTS:In this study, we included 20 492 neonates, 79 744 infants, and 382 862 children. Postoperative development of VTE was reported in 99 (0.48%) neonates, 147 (0.2%) infants, and 374 (0.1%) children. In all age groups, development of VTE was significantly more common among patients with a perioperative RBC transfusion than patients without a perioperative RBC transfusion (neonates: adjusted odds ratio [aOR] = 4.1, 95% confidence interval [CI] = 2.5–6.7; infants: aOR = 2.4, 95% CI = 1.7–3.6; children: aOR = 2.2, 95% CI = 1.7–2.9). Among children who received an intra- or postoperative transfusion, the weight-based volume of RBCs (mL/kg) transfused was associated with postoperative VTE in a dose-dependent manner: second tertile (odds ratio = 2.3, 95% CI = 1.3–4.1) and third tertile (odds ratio = 4.1, 95% CI = 2.3–7.4) versus first tertile.CONCLUSIONS:Perioperative RBC transfusions are independently associated with development of new or progressive postoperative VTE in children, infants, and neonates. These findings need further validation in prospective studies and emphasize the need for evidence-based perioperative pediatric blood transfusion decisions.
Expression of gene encoding flavonol synthase isolating from trung du xanh tea <i>(Camellia sinensis </i> var. <i> macrophylla) </i> in <i> E. coli </i>
Authors: Yen Hoang Thi Thu , Lan Vu Thi , Thu Hue Huynh Thi 
Published: March 2020

Common flavonols in plants including quercetin, kaempferol and myricetin are synthesized from dihydroflavonols (dihydroquercetin-DHQ, dihydrokaempferol-DHK and dihydromyricetin-DHM) by flavonol synthase (FLS). In tea, FLS has been shown to metabolize dihydroquercetin to quercetin. The FLS gene was cloned and sequenced from the cultivated tea (Camellia sinensis var. macrophylla) in Thai Nguyen province. In this study, we presented the results of optimizing and designing an expression vector for recombinant FLS (recombinant FLS-rFLS). The FLS gene was ligated completely to the pET32a (+) vector, then expressed in E. coli Rosetta1 and Rosetta2 strain. Using 1mM IPTG to induce the expression of rFLS at 37oC, rFLS was obtained with 52.83 kDa in size and existed predominantly as insoluble form. E. coli Rosetta1 pET32a (+)_FLSproduces rFLS in the soluble fraction than E. coli Rosetta2 pET32a (+)_FLS. Next, E. coli Rosetta1 pET32a (+)_FLSwas optimized for expression at temperatures of 30oC, 23oC and 16oC (24 and 48 hours). After being induced for expression with 1mM IPTG in 48 hours and cultured at 16oC, E. coli Rosetta1 strain containing pET32a (+) FLS produced the largest amount of rFLS in the soluble form.
Effect of Information Technology on Social Movements: A case study of Arab countries
Authors: Gul Yasmeen 
Published: March 2020

Social networking websites are: face book, twitter, beebo, orkut etc. The fact is that this technological advancement is changing the urban sociology drastically. Its effects range from personal friendships to political movements.
The demonstrations in Iran were mainly organised through face book and twitter. They had a major role in the overthrow of Tunisian president. There are wide spread protests in Egypt also. People of Egypt were demanding the end of Hosni Mubarak's regime and Egyptian government has banned both face book and twitter because people were demanding that president Hosni Mubarak should resign.
These websites don't start any movement but people who start movements use them to contact public. Previously it was difficult to arrange demonstrations and political parties had to announce in advance, which gave the government the chance to put a ban or just block the area where demonstration was to be held but now what they do is they just announce it one hour before the actual time and the government has no time to control it, that is why these websites have made political demonstrations more effective.
On the personal level they have made it easier to maintain contact with your friends but the level of close friendships is reduced. Previously we used to have few friends and one or two were very close friends but now we have hundreds of friends but no one is close. Besides dedicating more time to online activities means we have less time to actually go out and meet friends. This phenomenon is very common in the developed world. It is a major change and we still don't know where this change is leading.
The other aspect of technological advancement is that now knowledge is not restricted. Everybody and anybody can learn whatever they want all they need is an internet connection. The fact is nobody can close the internet. So internet in effect is the new super power in the world. America is not the super power internet is because America cannot close the internet but internet can close America.
The Impact of HR Policies over the Financial Soundness of Commercial Banks: A Study on Dhaka Bank Limited
Authors: Rahman Benazir , Islam Yeasmin , Ahmad Fahmida 
Published: March 2020

Presently Human Resources (HR) Management has become one of the burning topics in our corporate world to operate overall activities of the organizations smoothly to ensure financial stability and banking industry is not an exception. Banking is one of the most significant sectors of the world economy and especially in a developing country like Bangladesh. Bank employees are the representative of the bank as it is a service-oriented organization, and they are providing banking services to the clients. The more customers’ retention will lead to more revenue as well as financial profit. The banks are now more concern about their employee’s development to make sure the highest productivity of their employees. The paper shows the importance of efficiency and effectiveness of HR policies to upward financial profit and sustainable growth of the bank. Dhaka Bank Limited (DBL) has taken as a sample bank among all the private commercial banks in Bangladesh to conduct the study. The study includes both descriptive as well as quantitative analysis like showing performance by using financial ratios and the impact of HR costs over the profitability. Sample survey has done among the DBL employees to collect data for the study. The study discloses that the banks are investing the huge amount of fund to develop HR strategies and to motivate employees so that the employee turnover will reduce and productivity will increase which leads to better performance to make sure financial profitability and growth. Usually to maintain all rules and regulation of HR, the banks have to expense more but its conveying long-term productive effect on business growth. It also creates a competitive advantage of the bank to compete with others bank. This study may be helpful for banks regarding dealing with profitability and HR strategies.
Exploration of the Historical and Cultural Aspects of “Yuanchangbu” in Chinese Classical Dance
Authors: Xu Xiang 
Published: March 2020

The main purpose of this paper is to explore and analyze the unknown Chinese emotions hidden behind the movement “Yuanchangbu,” and to find out the meaning behind it from a cultural and historical viewpoint. We will rediscover some of the silences in history and restore the psychology, emotion and movement of Chinese classical dance. Therefore, this paper will, firstly, set “Yuanchangbu” as a clue through which to explore how the movement in daily life developed into the movement of Chinese classical dance.
Furthermore, due to the impact of ancient Chinese foot binding culture on the formation of “Yuanchangbu”, this paper, based on research of the movement, will also explore the era of foot binding. We will understand the changing progress of Chinese men and women’s lifestyle from the era of the natural-foot to foot binding. And at this moment trigger further thought on the culture and style of Chinese traditional dance by the “foot-binding culture.”
Dieta jako czynnik ryzyka choroby Alzheimera
Authors: Stępkowski Dariusz , Studnicki Marcin , Woźniak Grażyna , Dębski Konrad 
Published: March 2020

Chroniczne spożywanie niezdrowej diety jest jedną z przyczyn chorób cywilizacyjnych i wpływa znacząco na średnią długość życia społeczeństw. Wpływ diety na zdrowie jest niezwykle skomplikowany ze względu na chemiczną różnorodność jej składu. Dieta dostarcza ponad 26 tysięcy składników i jeszcze większej liczby ich metabolitów. Wśród tej różnorodności można wydzielić trzy makroskładniki: białka, węglowodany oraz tłuszcze dostarczające energii. Według najnowszych koncepcji wpływu makroskładników w diecie na funkcjonowanie organizmu człowieka, na zdrowie człowieka oddziałują także wzajemne proporcje makroskładników, a nie jedynie ich bezwzględne ilości. W artykule prezentujemy krótkie omówienie badań własnych dotyczących wpływu diety na zapadalność na chorobę Alzheimera. Nasze wyniki uzyskane metodami statystycznymi konfrontujemy z wiedzą zawartą w literaturze biochemicznej i epidemiologicznej tego tematu.
Enredados con la sierra. Las plantas en las estrategias sostenibles de sobrevivencia del grupo indígena Guarijío/Makurawe de Sonora, México
Authors: Bañuelos Flores Noemi , Salido-Araiza Patricia L. 
Published: March 2020

Los Guarijío/Makurawe de Sonora representan uno de los pueblos indígenas más olvidados en el noroeste de México. El presente trabajo analiza desde una perspectiva etnobotánica la importancia que para este grupo indígena guardan los recursos vegetales, a partir del examen de sus distintas formas de aprovechamiento. La metodología utilizada se apoyó en la aplicación de entrevistas personales a profundidad, observación directa y participativa así como talleres comunitarios. Las personas de mayor edad, amas de casa, trabajadores del campo, artesanos, curanderos, rezandero, promotor cultural bilingüe y el gobernador del pueblo, fueron actores claves en la búsqueda de información. Algunos resultados revelan que los Guarijío personifican un ejemplo de sobrevivencia con base en las formas de uso de su patrimonio biocultural. Los saberes indígenas respecto a los recursos vegetales, representan las raíces desde donde debe plantearse cualquier propuesta de desarrollo sostenible que busque mejorar las condiciones de bienestar de este pueblo.
Risk Reduction Interventions for Human Papillomavirus in Rural Maryland
Authors: Jafari S. Dale G. , Appel Susan J. , Shorter D. Gail 
Published: March 2020

BackgroundHuman papillomavirus (HPV) is largely vaccine preventable. The Healthy People 2020 target goal for vaccine administration is 80%. Current United States (U. S.) rates are far lower primarily because of vaccine hesitancy and lack of provider recommendation.ObjectiveImplement a risk reduction initiative to increase HPV vaccine rates in females aged 12–26 in five rural counties in Maryland.MethodsA convenience sample from a rural community screened an HPV documentary movie, Questionnaire responses pre- and postscreening were surveyed for impact on vaccine readiness. Postscreening focus group comments were analyzed for common themes. Females aged 12–26 from a University Medical Group Women's Health Center located in rural Maryland were targeted. Chart review of immunization records 90 days pre- and postprovider vaccine recommendation demonstrated impact.ResultsPublic awareness events have the potential to impact HPV vaccine hesitancy, but this research did not achieve statistical significance. Direct provider to patient recommendations resulted in a 15% increase in HPV immunizations.ConclusionsEducation of vaccine-eligible individuals should be undertaken.Implications for NursingProviders who recommend administration of the vaccine significantly increase immunization rates.
Analysis Strategies for Rabies Prevention and Control in China
Authors: Li Jia , Shi Leitai , Wang Yunpeng , Cao Shouchun 
Published: March 2020

Objective To analyze the current epidemiological characteristics of rabies in China, grasp the law of epidemic changes, and provide scientific basis for rabies prevention and control strategies in China. Methods The data of human rabies prevention and control in China were systematically collected, combined with the genetic sequences of rabies virus street virus epidemic strains in various provinces of China, and statistical and molecular biological methods were used for statistics and analysis. Results The number of rabies cases and deaths in China has decreased year by year. At present, the main method of human rabies transmission in China is dog injury. Post-exposure treatment showed an increase in the rate of self-treatment, a decline in the overall immunity rate of the vaccine, and an increase in the rate of passive immunity. Human rabies vaccines are currently available to meet vaccination needs. In addition, the immune rates of dogs and cats did not change significantly. The rabies street virus strains in China are mainly divided into 6 species including China Ⅰ-China Ⅵ. Conclusion In terms of infrastructure, it is still necessary to increase the number of primary clinics, improve the professional capabilities of medical staff, and strengthen publicity and education on rabies prevention and treatment. In the areas with high incidence of cases, vaccines similar to street strain should be selected for immunization of human and animal.
Relative position of the central hole after EVO-ICL implantation for moderate to high myopia
Authors: He Xiaojian , niu lingling , Miao Huamao , zhao feng , Zhou Xingtao 
Published: March 2020

Abstract
Background: This study aimed to evaluate the relative position of the central hole (C H ) of EVO Implantable Collamer Lens (EVO-ICL), the pupil center (C P ), and the corneal center (C C ) after implantation of EVO-ICLs for moderate to high myopia.
Methods: Eighty-nine eyes of forty-seven patients with moderate to high myopia were evaluated. The mean preoperative spherical equivalent (SE) was -12.58 ± 4.13D. A routine postoperative follow-up was performed within 1~12 months. Positions of the C H of EVO-ICLs, the C P and the C C were recorded using a slit lamp anterior segment photography system, and their relative distances were calculated with the Visio image analysis software.
Results: All surgeries were performed safely, and no complications were observed in follow-ups 4.3 ± 4.82 months after surgery. At the last follow-up, the safety index (postoperative CDVA/preoperative CDVA) was 1.23 ± 0.48, and the efficacy index (postoperative UDVA/preoperative CDVA) was 1.08 ± 0.31. The C H in 85 eyes (95.51%) was superior to the C C , with 47.19% (42/89) on the temporal side and 48.31% (43/89) on the nasal side. The C H in 84 eyes (94.38%) was located on the temporal side of the C P , with 56.18% (50/89) superior and 38.2% (34/89) inferior to the C P . The C P of eighty-five eyes (95.51%) was superior on the nasal side of the C C . On the defined x-axis, the average distance from the C H to C C was significantly shorter than the average distance from the C P to C C ( p < 0.001).
Conclusions: An imperfect mismatch between the central hole of EVO-ICLs and the pupil center does not necessarily indicate ICL dislocation. Compared to the pupil center, the position of the central hole of EVO-ICL is closer to the corneal center.