bluuebunny/crossref_metadata_2025_split huggingface dataset:
A hybridizable discontinuous Galerkin phase‐field model for brittle fracture with adaptive refinement
Authors: Muixí Alba , Rodríguez‐Ferran Antonio , Fernández‐Méndez Sonia 
Published: October 2019

SummaryIn this paper, we propose an adaptive refinement strategy for phase‐field models of brittle fracture, which is based on a novel hybridizable discontinuous Galerkin (HDG) formulation of the problem. The adaptive procedure considers standard elements and only one type of h‐refined elements, dynamically located along the propagating cracks. Thanks to the weak imposition of interelement continuity in HDG methods, and in contrast with other existing adaptive approaches, hanging nodes or special transition elements are not needed, which simplifies the implementation. Various numerical experiments, including one branching test, show the accuracy, robustness, and applicability of the presented approach to quasistatic phase‐field simulations.
Proteomic Research of Molecular Defects in Globozoospermia
Authors: Ferrero Simone , Barra Fabio 
Published: October 2019

AbstractGlobozoospermia is a form of teratozoospermia characterized by round‐headed spermatozoa and lack of acrosome. These spermatozoa cannot penetrate the zona pellucida of the oocyte, resulting in unsuccessful fertilization and infertility. When intracytoplasmic sperm injection is performed, the fertilization rate tends to be low. Until now, the causes of this disorder remain to be elucidated; however, mutations of some genes segregating on an autosomal recessive mode have been associated with this infertile condition. DPY19L2 (dpy‐19‐like 2 [Caenorhabditis elegans]) codes for a transmembrane protein expressed predominantly in spermatids, with specific localization limited to the internal nuclear membrane. Genetic defects in the DPY19L2 gene have been demonstrated the most frequent genetic cause of globozoospermia; however, intracellular molecular pathways related to its encoded protein are largely unknown. In this issue of Proteomics Clinical Applications, Guo and co‐workers investigate the proteome of gloobozoospermic spermatozoa. The authors identified 491 proteins that are differentially expressed in globozoospermia (370 are upregulated and 121 are downregulated in DPY19L2‐deficient globozoospermic sperm). Notably, the molecular defects identified by the authors are closely related to biological processes involved in acrosome formation, chromatin composition, sperm‐egg binding, and fertilization.
Structural stability and evolution of terbium‐doped silicon clusters and influence of 4f → 5d electronic transition mechanism on magnetism and appearance of photoelectron spectroscopy for TbSin0/− (n = 6‐18) clusters
Authors: Gu Yansong , Yang Jucai , Cheng Lin 
Published: October 2019

AbstractThe global minimal structures of terbium‐doped Si clusters and their anions TbSi
n0/− (n = 6‐18) are confirmed by employing the ABCluster unbiased global search technique combined with a B2PLYP double‐hybrid density functional and comparing consistency of simulated and experimental photoelectron spectroscopy (PES). The results demonstrated that structural evolution patterns for neutral clusters prefer Tb‐substitutional to Tb‐encapsulated configuration starting from n = 16. While for the corresponding anionic clusters, the growth pattern adopts Tb‐linked structures to encapsulated motif. The Natural Population Analysis revealed that the 4f electrons of Tb atom in TbSi
n0/− (n = 6‐18) clusters participate in bonding. The way to participate in bonding is one 4f electron transition to 5d orbital ([Xe]6s24f9 → [Xe]6s24f85d1), which significantly affects the cluster's magnetism and appearance of PES. The total magnetic moments of neutral TbSi
n and the corresponding anions maintain at 7 μB and 6 μB, respectively, which are larger than that of an isolated Tb atom. The HOMO‐LUMO energy gap, relative stability, and chemical bonding analysis demonstrated that superatomic TbSi16− cluster is a magic cluster with fine thermodynamic and moderate chemical stability.
High‐Performance Inverted Planar Perovskite Solar Cells Enhanced by Thickness Tuning of New Dopant‐Free Hole Transporting Layer
Authors: Lai Xue , Du Mengzhen , Meng Fei , Li Gongqiang , Li Wenhui , Kyaw Aung Ko Ko , Wen Yaping , Liu Chungen , Ma Haibo , Zhang Ren , Fan Dongyu , Guo Xiao , Wang Yunhao , Ji Hongru , Wang Kai , Sun Xiao Wei , Wang Jianpu , Huang Wei 
Published: October 2019

AbstractA new hole transporting material (HTM) named DMZ is synthesized and employed as a dopant‐free HTM in inverted planar perovskite solar cells (PSCs). Systematic studies demonstrate that the thickness of the hole transporting layer can effectively enhance the morphology and crystallinity of the perovskite layer, leading to low series resistance and less defects in the crystal. As a result, the champion power conversion efficiency (PCE) of 18.61% with JSC = 22.62 mA cm−2, VOC = 1.02 V, and FF = 81.05% (an average one is 17.62%) is achieved with a thickness of ≈13 nm of DMZ (2 mg mL−1) under standard global AM 1.5 illumination, which is ≈1.5 times higher than that of devices based on poly(3,4‐ethylenedioxythiophene)/poly(styrene sulfonic acid) (PEDOT:PSS). More importantly, the devices based on DMZ exhibit a much better stability (90% of maximum PCE retained after more than 556 h in air (relative humidity ≈ 45%–50%) without any encapsulation) than that of devices based on PEDOT:PSS (only 36% of initial PCE retained after 77 h in same conditions). Therefore, the cost‐effective and facile material named DMZ offers an appealing alternative to PEDOT:PSS or polytriarylamine for highly efficient and stable inverted planar PSCs.
Sensitivity analysis of the failure time of reinforcement concrete frame under postearthquake fire loading
Authors: Moradi Majid , Tavakoli Hamidreza , AbdollahZade GholamReza 
Published: October 2019

AbstractToday, many scholars have drawn attention to consecutive events such as postearthquake fire (PEF). PEF is one of the rare occurrences that leads to many consequences. The resistance of structure against external loads is important for structure and earthquake engineers. The duration of structures' resistance against fire in damaged structures due to earthquake can be different from intact ones. Many parameters have an effect on the resistance of structures. This paper deals with the importance of design parameters and loading for the resistance of reinforced concrete frames during PEF loading. Three methods of Monte Carlo, Tornado diagram, and first‐order second moment have been used to analysis based on random variables. The first failure time in the reinforcement concrete frame (RC) is considered as the strength of the reinforced concrete frame to PEF load. The results depicted that among design parameters, yield stress of rebar is the most significant parameter for the resistance of reinforced concrete frames. Among the loading parameters, the intensity of the seismic load is the most important parameter. The sensitivity of the failure time of members in RC frame shows that during the low intensity of earthquakes, the cover of concrete is the main design parameter after yield strength of rebar. As the intensity of seismic loads increases, the effect of concretes' cover on the resistance of structures against fire decreases. The sensitivity of the failure time to intensity of seismic load is higher between Sa = 0.3 g to Sa = 0.8 g. Also, results show the sensitivity of the design variable decreases by increasing the intensity of the seismic load.
M5 branes and theta functions
Authors: Haghighat Babak , Sun Rui 
Published: October 2019

Abstract
We propose quantum states for Little String Theories (LSTs) arising from M5 branes probing A- and D-type singularities. This extends Witten’s picture of M5 brane partition functions as theta functions to this more general setup. Compactifying the world-volume of the five-branes on a two-torus, we find that the corresponding theta functions are sections of line bundles over complex 4-tori. This formalism allows us to derive Seiberg-Witten curves for the resulting four-dimensional theories. Along the way, we prove a duality for LSTs observed by Iqbal, Hohenegger and Rey.
The accuracy and accessibility of cited evidence: a study examining mental health policy documents
Authors: Hui Aika , Rains Luke Sheridan , Todd Anita , Boaz Annette , Johnson Sonia 
Published: October 2019

AbstractPurposeEvidence-based policy making is increasingly being advocated by governments and scholars. To show that policies are informed by evidence, policy-related documents that cite external sources should ideally provide direct access to, and accurately represent, the referenced source and the evidence it provides. Our aim was to find a way to systematically assess the prevalence of referencing accuracy and accessibility issues in referenced statements selected from a sample of mental health-related policy documents.Method236 referenced statements were selected from 10 mental health-related policy documents published between 2013 and 2018. Policy documents were chosen as the focus of this investigation because of their relative accessibility and impact on clinical practice. Statements were rated against their referenced sources in terms of the (i) content accuracy in relation to the information provided by the referenced source and (ii) degree of accessibility of the source and the required evidence from the references provided.ResultsOf the 236 statements, 141 (59.7%) accurately represented the referenced source, 45 (19.1%) contained major errors and 50 (21.2%) contained minor errors in accuracy. For accessibility, 126 (53.4%) directly referenced primary sources of evidence that supported the claims made, 36 (15.3%) contained indirect references, 18 (7.6%) provided ‘dead-end’ references, and 11 (4.7%) references were completely inaccessible.ConclusionsWith only slightly over half of all statements assessed providing fully accessible references and accurately representing the referenced source, these components of referencing quality deserve further attention if evidence-informed policy goals are to be achieved. The rating framework used in the current study proved to be a simple and straightforward method to assess these components and can provide a baseline against which interventions can be designed to improve referencing quality.
Twenty common errors in the diagnosis and treatment of periprosthetic joint infection
Authors: Li Cheng , Renz Nora , Trampuz Andrej , Ojeda-Thies Cristina 
Published: October 2019

AbstractBackgroundMisconceptions and errors in the management of periprosthetic joint infection (PJI) can compromise the treatment success. The goal of this paper is to systematically describe twenty common mistakes in the diagnosis and management of PJI, to help surgeons avoid these pitfalls.Materials and methodsCommon diagnostic and treatment errors are described, analyzed and interpreted.ResultsDiagnostic errors include the use of serum inflammatory biomarkers (such as C-reactive protein) to rule out PJI, incomplete evaluation of joint aspirate, and suboptimal microbiological procedures (such as using swabs or collection of insufficient number of periprosthetic samples). Further errors are missing possible sources of distant infection in hematogenous PJI or overreliance on suboptimal diagnostic criteria which can hinder or delay the diagnosis of PJI or mislabel infections as aseptic failure. Insufficient surgical treatment or inadequate antibiotic treatment are further reasons for treatment failure and emergence of antimicrobial resistance. Finally, wrong surgical indication, both underdebridement and overdebridement or failure to individualize treatment can jeopardize surgical results.ConclusionMultidisciplinary teamwork with infectious disease specialists and microbiologists in collaboration with orthopedic surgeons have a synergistic effect on the management of PJI. An awareness of the possible pitfalls can improve diagnosis and treatment results.
EBV-associated lymphoproliferative disorder involving the gastrointestinal tract which mimic IBD in immunocompetent patients: case reports and literature review
Authors: Zhou Yanhua , Zhang Yanlin , Zhao Haiying , Cui Xuan , Wei Yongqiu , Wu Yongdong , Zhang Shutian , Zong Ye 
Published: October 2019

Abstract

Introduction
Epstein-Barr virus (EBV)–associated lymphoproliferative diseases (LPD) with digestive tract involvement in immunocompetent patients is rather rare. Since the symptoms of EBV-associated LPD involving the gastrointestinal tract in immunocompetent patients are similar to those of inflammatory bowel disease (IBD), most patients are initially misdiagnosed.

Case presentation
In this paper, we present two cases of EBV-associated T cell LPD involving the colon in immunocompetent patients and review the relevant literature.

Conclusion
EBV serological testing may help in detecting this disease, and our findings suggest that histopathological evidence of EBV, such as the Epstein-Barr encoding region, is very important to establish the diagnosis.
Views of nursing staff on computerized dementia screening
Authors: Zygouris Stelios , Gkioka Mara , Moraitou Despoina , Teichmann Birgit , Tsiatsos Thrasyvoulos , Papagianopoulos Sotirios , Tsolaki Magda 
Published: October 2019

Abstract

Background
Cognitive disorders such as dementia are common among older adults admitted to general hospitals. They can complicate treatment leading to longer hospitalization and worse outcomes. They often remain underdiagnosed as the busy routine of the hospital does not enable efficient screening and available screening instruments are not suitable for the hospital environment. Computerized cognitive testing (CCT) has been proposed as an efficient screening method as it can be employed by nonspecialists, such as nurses while featuring automatic scoring and interpretation of results.

Objective
This study validated a newly developed questionnaire for measuring the attitudes of Greek nurses towards computerized dementia screening.

Material and methods
The questionnaire was validated in a sample of 212 undergraduate psychology students and subsequently administered to a sample of 19 nurses working in a general hospital. Reliability of the questionnaire was calculated using Cronbach’s alpha (= 0.762). Factor analysis revealed the existence of a single factor (acceptability-feasibility) that accounted for 33.73% of variance with an eigenvalue of 3.036.

Results
The total score of all the items loading on the single factor (acceptability-feasibility) was calculated. Scores ranged between 10 and 40 with the average score for the validation group being 29.33 (SD = 4.89) and the average score for the nurses’ group being 29.50 (SD = 3.20).

Discussion
The questionnaire has acceptable reliability. Results indicate that acceptability-feasibility is high in both groups and there were no statistically significant differences between the two groups.
Targeting the delivery of dietary plant bioactives to those who would benefit most: from science to practical applications
Authors: de Roos Baukje , Aura Anna-Marja , Bronze Maria , Cassidy Aedin , Conesa María-Teresa Garcia , Gibney Eileen R. , Greyling Arno , Kaput Jim , Kerem Zohar , Knežević Nada , Kroon Paul , Landberg Rikard , Manach Claudine , Milenkovic Dragan , Rodriguez-Mateos Ana , Tomás-Barberán Francisco A. , van de Wiele Tom , Morand Christine 
Published: October 2019

AbstractBackgroundA healthy diet and optimal lifestyle choices are amongst the most important actions for the prevention of cardiometabolic diseases. Despite this, it appears difficult to convince consumers to select more nutritious foods. Furthermore, the development and production of healthier foods do not always lead to economic profits for the agro-food sector. Most dietary recommendations for the general population represent a “one-size-fits-all approach” which does not necessarily ensure that everyone has adequate exposure to health-promoting constituents of foods. Indeed, we now know that individuals show a high variability in responses when exposed to specific nutrients, foods, or diets.PurposeThis review aims to highlight our current understanding of inter-individual variability in response to dietary bioactives, based on the integration of findings of the COST Action POSITIVe. We also evaluate opportunities for translation of scientific knowledge on inter-individual variability in response to dietary bioactives, once it becomes available, into practical applications for stakeholders, such as the agro-food industry. The potential impact from such applications will form an important impetus for the food industry to develop and market new high quality and healthy foods for specific groups of consumers in the future. This may contribute to a decrease in the burden of diet-related chronic diseases.
Future prospects for dissecting
inter-individual variability in the absorption, distribution and elimination of plant
bioactives of relevance for cardiometabolic endpoints
Authors: Landberg Rikard , Manach Claudine , Kerckhof Frederiek-Maarten , Minihane Anne-Marie , Saleh Rasha Noureldin M. , De Roos Baukje , Tomas-Barberan Francisco , Morand Christine , Van de Wiele Tom 
Published: October 2019

Abstract

Purpose
The health-promoting potential of food-derived plant bioactive
compounds is evident but not always consistent across studies. Large
inter-individual variability may originate from differences in digestion,
absorption, distribution, metabolism and excretion (ADME). ADME can be modulated
by age, sex, dietary habits, microbiome composition, genetic variation, drug
exposure and many other factors. Within the recent COST Action POSITIVe,
large-scale literature surveys were undertaken to identify the reasons and
extent of inter-individual variability in ADME of selected plant bioactive
compounds of importance to cardiometabolic health. The aim of the present review
is to summarize the findings and suggest a framework for future studies designed
to investigate the etiology of inter-individual variability in plant bioactive
ADME and bioefficacy.

Results
Few studies have reported individual data on the ADME of bioactive
compounds and on determinants such as age, diet, lifestyle, health status and
medication, thereby limiting a mechanistic understanding of the main drivers of
variation in ADME processes observed across individuals. Metabolomics represent
crucial techniques to decipher inter-individual variability and to stratify
individuals according to metabotypes reflecting the intrinsic capacity to absorb
and metabolize bioactive compounds.

Conclusion
A methodological framework was developed to decipher how the
contribution from genetic variants or microbiome variants to ADME of bioactive
compounds can be predicted. Future study design should include (1) a larger
number of study participants, (2) individual and full profiling of all possible
determinants of internal exposure, (3) the presentation of individual ADME data
and (4) incorporation of omics platforms, such as genomics, microbiomics and
metabolomics in ADME and efficacy studies.
Effect of food-related behavioral activation therapy on food intake and the environmental impact of the diet: results from the MooDFOOD prevention trial
Authors: Grasso Alessandra C. , Olthof Margreet R. , van Dooren Corné , Roca Miquel , Gili Margalida , Visser Marjolein , Cabout Mieke , Bot Mariska , Penninx Brenda W. J. H. , van Grootheest Gerard , Kohls Elisabeth , Hegerl Ulrich , Owens Matthew , Watkins Ed , Brouwer Ingeborg A. ,   the MooDFOOD Prevention Trial Investigators, Visser Marjolein , Brouwer Ingeborg A. , Cabout Mieke , Penninx Brenda , Bot Mariska , Paans Nadine , Thesing Carisha , Gibson-Smith Deborah , Horsfall Melany , Weiss Lena , Watkins Ed , Owens Matthew , Romijn Amy , Bunce Hannah , Winfield Owain , Roca Miquel , Gili Margarita , Tortella Miquel , Covas Clara Homar , Forteza Margalida Vives , Gracia Adoración Castro , Pérez-Ara Maria Angeles , Reig José Luis , Hegerl Ulrich , Kohls Elisabeth , Hoesel Jana , Dogan Ezgi , Baldofski Sabrina , Mauche Nicole , Penninx Brenda , van Grootheest Gerard , Verkerk Bep 
Published: October 2019

Abstract
Purpose
Food-based dietary guidelines are proposed to not only improve diet quality, but to also reduce the environmental impact of diets. The aim of our study was to investigate whether food-related behavioral activation therapy (F-BA) applying Mediterranean-style dietary guidelines altered food intake and the environmental impact of the diet in overweight adults with subsyndromal symptoms of depression.

Methods
In total 744 adults who either received the F-BA intervention (F-BA group) or no intervention (control group) for 12 months were included in this analysis. Food intake data were collected through a food frequency questionnaire at baseline and after 6 and 12 months. Greenhouse gas emissions (GHGE), land use (LU), and fossil energy use (FEU) estimates from life-cycle assessments and a weighted score of the three (pReCiPe score) were used to estimate the environmental impact of each individual diet at each timepoint.

Results
The F-BA group reported increased intakes of vegetables (19.7 g/day; 95% CI 7.8–31.6), fruit (23.0 g/day; 9.4–36.6), fish (7.6 g/day; 4.6–10.6), pulses/legumes (4.0 g/day; 1.6–6.5) and whole grains (12.7 g/day; 8.0–17.5), and decreased intake of sweets/extras (− 6.8 g/day; − 10.9 to − 2.8) relative to control group. This effect on food intake resulted in no change in GHGE, LU, and pReCiPe score, but a relative increase in FEU by 1.6 MJ/day (0.8, 2.4).

Conclusions
A shift towards a healthier Mediterranean-style diet does not necessarily result in a diet with reduced environmental impact in a real-life setting.

Trial registration
ClinicalTrials.gov. Number of identification: NCT02529423. August 2015.
Quantitative trait loci for starch-corrected chip color after harvest, cold storage and after reconditioning mapped in diploid potato
Authors: Sołtys-Kalina Dorota , Szajko Katarzyna , Wasilewicz-Flis Iwona , Mańkowski Dariusz , Marczewski Waldemar , Śliwka Jadwiga 
Published: October 2019

AbstractThe objective of this study was to map the quantitative trait loci (QTLs) for chip color after harvest (AH), cold storage (CS) and after reconditioning (RC) in diploid potato and compare them with QTLs for starch-corrected chip color. Chip color traits AH, CS, and RC significantly correlated with tuber starch content (TSC). To limit the effect of starch content, the chip color was corrected for TSC. The QTLs for chip color (AH, CS, and RC) and the starch-corrected chip color determined with the starch content after harvest (SCAH), after cold storage (SCCS) and after reconditioning (SCRC) were compared to assess the extent of the effect of starch and the location of genetic factors underlying this effect on chip color. We detected QTLs for the AH, CS, RC and starch-corrected traits on ten potato chromosomes, confirming the polygenic nature of the traits. The QTLs with the strongest effects were detected on chromosomes I (AH, 0 cM, 11.5% of variance explained), IV (CS, 43.9 cM, 12.7%) and I (RC, 49.7 cM, 14.1%). When starch correction was applied, the QTLs with the strongest effects were revealed on chromosomes VIII (SCAH, 39.3 cM, 10.8% of variance explained), XI (SCCS, 79.5 cM, 10.9%) and IV (SCRC, 43.9 cM, 10.8%). Applying the starch correction changed the landscape of QTLs for chip color, as some QTLs became statistically insignificant, shifted or were refined, and new QTLs were detected for SCAH. The QTLs on chromosomes I and IV were significant for all traits with and without starch correction.