bluuebunny/crossref_metadata_2025_split huggingface dataset:
A prospective journey of the peripherally inserted central catheter service, at a tertiary paediatric centre in Western Australia
Authors: Hauser Neil D. , Chen Yu‐Ping , von Ungern‐Sternberg Britta S. 
Published: December 2019

BackgroundTo document the evolution of the Peripherally Inserted Central Catheter service at Princess Margaret Hospital, now Perth Children's Hospital.MethodsBetween January 2012 and June 2013 patients referred to Anaesthesia for a Peripherally Inserted Central Catheter were prospectively followed up. A repeat audit was conducted between January 2015 and June 2016, following the introduction of a number of measures aimed at improving the service.ResultsAudit 1: A total of 200 Peripherally Inserted Central Catheter insertions were attempted in 138 patients. Successful placement occurred in 86% of cases (172/200). The median age of patients was 7.71 years (range 0‐20). The percentage of Peripherally Inserted Central Catheters remaining in situ for the predicted duration was 49/172 (28.5%). Complications were documented in 78/172 (45.4%) of cases.Audit 2: A total of 310 Peripherally Inserted Central Catheter placements were attempted in 244 patients. Successful insertion rate was 95.5% (296/ 310). The median age of patients was 5.3 years (range 0.0‐18.72). The percentage remaining in situ for the predicted duration was 145/296 (49%). Complications were documented in 67/296 (22.6%) of cases.ConclusionThe evolution of the Peripherally Inserted Central Catheter service at our free standing Tertiary Paediatric Hospital is well documented following these 2 audits. The introduction of a dedicated Anaesthesia led Peripherally Inserted Central Catheter service at our centre has resulted in improved insertion success rates and a reduction in complications.
No benefit from flexible titration above minimum licensed dose in prescribing antidepressants for major depression: systematic review
Authors: Furukawa T. A. , Salanti G. , Cowen P. J. , Leucht S. , Cipriani A. 
Published: December 2019

BackgroundIn fixed‐dose antidepressant trials, the lower range of the licensed dose achieves the optimal balance between efficacy and tolerability. Whether flexible upward titration while side‐effects permit provides additional benefits is unknown.MethodsWe did a systematic review of placebo‐controlled randomized trials that examined selective serotonin reuptake inhibitors (SSRIs), venlafaxine or mirtazapine in the acute treatment of major depression. Our primary outcome was response, defined as 50% or greater reduction in depression severity. Secondary outcomes included drop‐outs due to adverse effects and drop‐outs for any reason. We conducted random‐effects meta‐analyses to calculate the ratios of odds ratios (RORs) between trials comparing the flexible dose titrating above the minimum licensed dose against placebo and those comparing the fixed minimum licensed dose against placebo.ResultsWe included 123 published and unpublished randomized controlled trials (29 420 participants). There was no evidence supporting efficacy of the flexible dosing over the fixed low dose of SSRIs (ROR 0.96, 95% CI: 0.73 to 1.25), venlafaxine (1.24, 0.96 to 1.60) or mirtazapine (0.77, 0.33 to 1.78). No important differences were noted for tolerability or for any subgroup analyses except the superior efficacy of venlafaxine flexible dosing between 75 and 150 mg over the fixed 75 mg (1.30, 1.02 to 1.65).ConclusionThere was no evidence to support added value in terms of efficacy, tolerability or acceptability of flexibly titrating up the dosage over the minimum licensed dose of SSRIs or mirtazapine. For venlafaxine, increased efficacy can be expected by flexibly titrating up to 150 mg.
Monetary policy and efficiency in over‐the‐counter financial trade
Authors: Geromichalos Athanasios , Jung Kuk Mo 
Published: December 2019

AbstractWe develop a monetary model that incorporates over‐the‐counter (OTC) asset trade. After agents have made their money holding decisions, they receive an idiosyncratic shock that affects their valuation for consumption and, hence, for the unique liquid asset, namely money. Subsequently, agents can choose whether they want to enter the OTC market in order to sell assets and thus boost their liquidity or to buy assets and thus provide liquidity to other agents. In our model, inflation affects not only the money holding decisions of agents, as is standard in monetary theory, but also the entry decision of these agents in the financial market. We use our framework to study the effect of inflation on welfare, asset prices and OTC trade volume. In contrast to most monetary models, which predict a negative relationship between inflation and welfare, we find that inflation can be welfare improving within a certain range, because it mitigates a search externality that agents impose on one another when they make their OTC market entry decision. Also, an increase in the holding cost of money will lead to a decrease in asset prices, a regularity that is well documented in the data and often considered anomalous.
Computer‐aided drug design of small molecule inhibitors of the ERCC1‐XPF protein–protein interaction
Authors: Gentile Francesco , Elmenoufy Ahmed H. , Ciniero Gloria , Jay David , Karimi‐Busheri Feridoun , Barakat Khaled H. , Weinfeld Michael , West Frederick G. , Tuszynski Jack A. 
Published: December 2019

AbstractThe heterodimer of DNA excision repair protein ERCC‐1 and DNA repair endonuclease XPF (ERCC1‐XPF) is a 5′–3′ structure‐specific endonuclease essential for the nucleotide excision repair (NER) pathway, and it is also involved in other DNA repair pathways. In cancer cells, ERCC1‐XPF plays a central role in repairing DNA damage induced by chemotherapeutics including platinum‐based and cross‐linking agents; thus, its inhibition is a promising strategy to enhance the effect of these therapies. In this study, we rationally modified the structure of F06, a small molecule inhibitor of the ERCC1‐XPF interaction (Molecular Pharmacology, 84, 2013 and 12), to improve its binding to the target. We followed a multi‐step computational approach to investigate potential modification sites of F06, rationally design and rank a library of analogues, and identify candidates for chemical synthesis and in vitro testing. Our top compound, B5, showed an improved half‐maximum inhibitory concentration (IC50) value of 0.49 µM for the inhibition of ERCC1‐XPF endonuclease activit, and lays the foundation for further testing and optimization. Also, the computational approach reported here can be used to develop DNA repair inhibitors targeting the ERCC1‐XPF complex.
Epiregulin promotes trophoblast epithelial–mesenchymal transition through poFUT1 and O‐fucosylation by poFUT1 on uPA
Authors: Cui Xinyuan , Wang Hao , Li Yaqi , Chen Tianhong , Liu Shuai , Yan Qiu 
Published: December 2019

AbstractObjectivesThe transformation of cytotrophoblasts into mesenchymal‐like extravillous trophoblasts is necessary for successful embryo implantation, and the inadequate transformation may cause abortion. Epiregulin, which is a new growth factor, plays important roles in the reproductive processes. The glycosylation of many proteins in reproduction processes is critical. Protein O‐fucosyltransferase 1 (poFUT1) is the key enzyme for the biosynthesis of O‐fucosylation on the specific glycoproteins. Urokinase‐type plasminogen activator (uPA) contains O‐fucosylated domain on Thr18. However, the functions of epiregulin and poFUT1 in the trophoblast epithelial–mesenchymal transition (EMT) process, the regulatory mechanism of epiregulin on poFUT1 and the resulting O‐fucosylated uPA remain unclear.Materials and methodsWe employed ELISA and Western blot to detect serum levels of epiregulin and poFUT1 from non‐pregnancy women, pregnancy women and abortion patients. Using two trophoblast cell lines and a mouse pregnancy model, we investigated the underlying mechanisms of epiregulin and poFUT1 in trophoblast EMT process.ResultsSerum levels of epiregulin and poFUT1 were higher in pregnant women compared with non‐pregnant women, and their levels were significantly decreased in abortion patients compared with pregnant women. The results showed that epiregulin upregulated poFUT1 expression and increased O‐fucosylation on uPA, which further activated the PI3K/Akt signalling pathway, facilitating EMT behaviour of trophoblast cells and embryo implantation in the mouse pregnant model.ConclusionsLevel of epiregulin and poFUT1 is lower in abortion patients than early pregnancy women. Epiregulin promotes trophoblast EMT through O‐fucosylation on uPA catalysed by poFUT1. Epiregulin and poFUT1 may be suggested as the potential diagnostic biomarkers and useful treatment targets for abortion.
Musical prediction error responses similarly reduced by predictive uncertainty in musicians and non‐musicians
Authors: Quiroga‐Martinez David R. , C. Hansen Niels , Højlund Andreas , Pearce Marcus , Brattico Elvira , Vuust Peter 
Published: December 2019

AbstractAuditory prediction error responses elicited by surprising sounds can be reliably recorded with musical stimuli that are more complex and realistic than those typically employed in EEG or MEG oddball paradigms. However, these responses are reduced as the predictive uncertainty of the stimuli increases. In this study, we investigate whether this effect is modulated by musical expertise. Magnetic mismatch negativity (MMNm) responses were recorded from 26 musicians and 24 non‐musicians while they listened to low‐ and high‐uncertainty melodic sequences in a musical multi‐feature paradigm that included pitch, slide, intensity and timbre deviants. When compared to non‐musicians, musically trained participants had significantly larger pitch and slide MMNm responses. However, both groups showed comparable reductions in pitch and slide MMNm amplitudes in the high‐uncertainty condition compared with the low‐uncertainty condition. In a separate, behavioural deviance detection experiment, musicians were more accurate and confident about their responses than non‐musicians, but deviance detection in both groups was similarly affected by the uncertainty of the melodies. In both experiments, the interaction between uncertainty and expertise was not significant, suggesting that the effect is comparable in both groups. Consequently, our results replicate the modulatory effect of predictive uncertainty on prediction error; show that it is present across different types of listeners; and suggest that expertise‐related and stimulus‐driven modulations of predictive precision are dissociable and independent.
Formation criterion for binary metal diboride solid solutions established through combinatorial methods
Authors: Wen Tongqi , Ye Beilin , Liu Honghua , Ning Shanshan , Wang Cai‐Zhuang , Chu Yanhui 
Published: December 2019

AbstractEstablishing the formation criterion is urgent for accelerating the discovery and design of solid‐solution materials with desirable properties. The previously reported formation criterion mainly focused on solid‐solution alloys, while the formation criterion was rarely established in solid‐solution ceramics. To solve this problem, herein, we take a class of solid‐solution ceramics, namely binary metal diboride ((MxN1‐x)B2) solid solutions, as a prototype. Through combinatorial methods including high‐throughput molten salt syntheses and high‐throughput first‐principles calculations combined with the machine learning approach, the correlation between influential factors, including atomic size difference (δ), mixing enthalpy at 0 K and 0 Pa (), doping condition (φ), and valence electron concentration (VEC), and the formation ability of (MxN1‐x)B2 solid solutions was first studied systematically, and then their formation criterion was well established. The results showed that the influential degree of the aforementioned four factors on the formation ability of (MxN1‐x)B2 solid solutions could be described as follows: δ > > φ > VEC. In addition, a newly proposed parameter, β, could well reflect the formation ability of (MxN1‐x)B2 solid solutions: when β > 0, the single‐phase (MxN1‐x)B2 solid solutions could be successfully synthesized in our work and vice versa. This study may provide a theoretical guidance in the discovery and design of various solid‐solution ceramics, such as the metal borides, carbides, nitrides, etc, with desirable properties.
Highly permeable Al2O3 microfiltration membranes with holey interior structure achieved through sacrificial C particles
Authors: Zhang Zhixiao , Ng Tze Chiang Albert , Gu Qilin , Zhang Lei , He Zeming , Lyu Zhiyang , Zhang Xiaorong , Wang Weimin , Ng How Yong , Wang John 
Published: December 2019

AbstractAlumina (Al2O3) microfiltration membranes with holey interior structure exhibit the combined desirable properties of both superior permeability and good retention performance. These membranes are purposely made to consist of a holey intermediate layer with a thickness in the range 12.9‐15.5 μm and a top filtration layer of very thin thickness in the range 1.8‐2.8 μm, fabricated by cosintering with sacrificial carbon (C) particles. The holey structure in the intermediate layer, which can be well controlled by regulating the amount of C particles added to Al2O3 particles, contains plenty of holes of 1‐5 μm in size, thereby possessing much reduced water flow resistance. The thin top filtration layer, which contains uniformly distributed nanopores of 90‐100 nm in size, functions as the selective layer, thereby ensuring a good retention performance. At the C particle content of 30 wt. %, the Al2O3 membrane with holey interior structure demonstrates a super‐high pure water flux (3358 Lm‐2h‐1), which is almost twice that of the membrane without holey interior structure (1697 Lm‐2h‐1), while the mechanical strength and retention performance are well maintained.
Suppression of nitridation of yttria‐doped zirconia during flash sintering
Authors: Kurachi Tsuyoshi , Yamashita Yudai , Tokunaga Tomoharu , Yoshida Hidehiro , Yamamoto Takahisa 
Published: December 2019

AbstractThe effect of direct current (DC) and alternating current (AC) on nitridation of 3 mol% Y2O3‐doped ZrO2 (3YSZ) after keeping in a flash state for 1 hour was investigated. The inside of the DC‐flashed compact was confirmed to exhibit blacking. Scanning transmission electron microscopy, electron energy loss spectroscopy, and X‐ray diffraction analysis revealed that zirconium nitrides formed in the blackened area. In contrast, a uniformly densified compact without blackening was obtained by AC fields. No zirconium nitrides formed in the compacts exposed to AC fields even when the flash state was maintained for 1 hour. Therefore, AC fields are effective to suppress nitridation of 3YSZ during flash sintering.
Comparative phylogeography of three host sea anemones in the Indo‐Pacific
Authors: Emms Madeleine A. , Saenz‐Agudelo Pablo , Giles Emily C. , Gatins Remy , Nanninga Gerrit B. , Scott Anna , Hobbs Jean‐Paul A. , Frisch Ashley J. , Mills Suzanne C. , Beldade Ricardo , Berumen Michael L. 
Published: December 2019

AbstractAimThe mutualistic relationship between anemones and anemonefishes is one of the most iconic examples of symbiosis. However, while anemonefishes have been extensively studied in terms of genetic connectivity, such information is lacking entirely for host sea anemones. Here, we provide the first information on the broad‐scale population structure and phylogeographical patterns of three species of host sea anemone, Heteractis magnifica, Stichodactyla mertensii and Entacmaea quadricolor. We evaluate if there is concordance in genetic structure across several distinct biogeographical areas within the Indo‐Pacific region and to what extent the observed patterns may concur with those found for anemonefishes.LocationIndo‐Pacific, including the Red Sea.TaxonHeteractis magnifica, S. mertensii and E. quadricolorMethodsMicrosatellite markers and a combination of statistical methods including Bayesian clustering, isolation by distance (IBD), analysis of molecular variance (AMOVA) and principal components analysis (PCA) were used to determine population structure. The congruence among distance matrices (CADM) method was used to assess similarity in spatial genetic patterns among species.ResultsSignificant population structure was identified in the three host anemone species. Each species is likely composed of at least two genetic clusters corresponding to two biogeographical regions, the Red Sea and the rest of the Indo‐Pacific. Two of the three anemone species seem to be experiencing admixture where the two main clusters overlap (the Maldives). IBD analyses in the Red Sea revealed differences in gene flow among species, suggesting more limited dispersal potential for E. quadricolor than for S. mertensii and H. magnifica. Clonality is documented in S. mertensii for the first time.Main conclusionsThis research documents the genetic population structure for three ecologically important host sea anemones across the Indo‐Pacific and provides valuable insights regarding their biogeography and evolution. Specifically, we found high levels of genetic divergence between populations across different biogeographical regions, suggesting different evolutionary lineages within species. At the same time, common geographical overlap of population structures suggests similar evolutionary histories among all three species. Interestingly, the observed patterns are congruent to some extent with structure reported for several anemonefish species, reflecting their close ecological association.
Highlights of the 2019 Japanese Society of Hypertension Guidelines and perspectives on the management of Asian hypertensive patients
Authors: Hoshide Satoshi , Kario Kazuomi , Tomitani Naoko , Kabutoya Tomoyuki , Chia Yook‐Chin , Park Sungha , Shin Jinho , Turana Yuda , Tay Jam Chin , Buranakitjaroen Peera , Chen Chen‐Huan , Nailes Jennifer , Minh Huynh Van , Siddique Saulat , Sison Jorge , Soenarta Arieska Ann , Sogunuru Guru Prasad , Sukonthasarn Apichard , Teo Boon Wee , Verma Narsingh , Zhang Yuqing , Wang Tzung‐Dau , Wang Ji‐Guang 
Published: December 2019

AbstractUnlike other international guidelines but in accord with the earlier Japanese Society of Hypertension (JSH) guidelines, the 2019 JSH guidelines (“JSH 2019”) continue to emphasize the importance of out‐of‐office blood pressure (BP) measurements obtained with a home BP device. Another unique characteristic of JSH 2019 is that it sets clinical questions about the management of hypertension that are based on systematic reviews of updated evidence. JSH 2019 states that individuals with office BP < 140/90 mm Hg do not have normal BP. The final decisions regarding the diagnosis and treatment of hypertension should be performed based on out‐of‐office BP values together with office BP measurements. For hypertensive adults with comorbidities, the office BP goal is usually <130/80 mm Hg and the home BP goal is <125/75 mm Hg. Recommendations of JSH 2019 would be valuable for not only Japanese hypertensive patients but also Asian hypertensive patients, who share the same features including higher incidence of stroke compared with that of myocardial infarction and a steeper blood pressure‐vascular event relationship.
Asian management of hypertension: Current status, home blood pressure, and specific concerns in Singapore
Authors: Tay Jam Chin , Teo Boon Wee 
Published: December 2019

AbstractDespite reductions in hypertension prevalence and improvements in control rates in recent years, almost one‐third of all deaths in Singapore are due to cardiovascular disease and that proportion is growing. Ischemic heart disease is the most common cause of cardiovascular death, ahead of stroke. Local data suggest that awareness and support for home blood pressure monitoring (HBPM) is good, but there are reservations about the accuracy of HBPM devices and physicians cited a lack of time and resources to educate patients about HBPM. In addition, there was a knowledge gap around use of HBPM for evaluating treatment response. This is consistent with the emphasis of using HBPM for the diagnosis, rather than monitoring, of hypertension in the Singapore hypertension guidelines. In the absence of specific HBPM thresholds and targets, it is suggested that HOPE Asia Network consensus documents provide the most locally relevant guidance of the use of HBPM. Calcium channel blockers and angiotensin receptor blockers are the most commonly used antihypertensive agents in Singapore, and monotherapy was relatively uncommon (24%) of patients. Overall, more needs to be done in detecting and managing hypertension in Singapore to address rates of cardiovascular disease and cardiovascular disease mortality. Use of HBPM needs to be encouraged to improve adherence to treatment and optimize BP targets according to Asian perspectives and data.
Chemical‐based resistance of Brassica oleracea and Rorippa dubia in response to Spodoptera litura attack
Authors: Pham Anh‐Tuan , Hwang Shaw‐Yhi 
Published: December 2019

AbstractA plant's chemical‐based resistance against insects can be characterized by an accumulation of phytochemicals that can severely harm or deter the generalist and non‐adapted specialist insects. In the absence of an herbivore threat, plants maintain a basic concentration of defensive compounds as a constitutive resistance mechanism. On the other hand, plants are capable of sharply increasing their production of defensive compounds as induced defence in response to herbivore attacks. In this study, we highlight the role of chemical‐based defence by comparing the constitutive and herbivore‐induced resistances of cauliflower (Brassica oleracea var. botrytis L.) and yellow cress (Rorippa dubia (Persoon)) with respect to time‐dependent changes of phytochemicals that directly influence the performance of the generalist herbivore insect, Spodoptera litura (Fabricius) (Lepidoptera: Noctuidae). The results of the study showed that both plant species were able to switch, albeit different degrees, between constitutive and induced resistances to combat herbivore attack. Brassica oleracea amassed lesser defensive compounds of constitutive resistance (trypsin inhibitor, polyphenol oxidase and sinigrin) than R. dubia. This led to a higher relative growth rate (RGR) of the S. litura larvae fed on cauliflower than in those fed on yellow cress. Brassica oleracea also demonstrated a lower induced response capability than R. dubia in its production of allelochemicals in herbivore‐induced resistances. This was shown by the decrease of the RGR of larvae fed on induced foliage of the cauliflower compared to those fed on yellow cress. These results of the study proved and added to the belief that modern crop variety is not only lower in constitutive resistance but also weaker in induced resistance capability against herbivores, which is likely to be an effect of domestication even Rorippa and Brassica are relatively far from each other in Brassicaceae phylogeny.