bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ordered arrangement of F4TCNQ anions in three-dimensionally oriented P3HT thin films
Authors: Nagamatsu Shuichi , Pandey Shyam S. 
Published: November 2020

AbstractAn ordered arrangement of electron-accepting molecular dopant, 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (F4TCNQ), in three-dimensionally (3D) oriented poly(3-hexylthiophene) (P3HT) film was clarified. The 3D oriented P3HT thin films prepared by the friction-transfer technique were doped with F4TCNQ by dipping into an acetonitrile solution. The presence of F4TCNQ anions in the 3D oriented P3HT thin films was investigated by polarized ultraviolet/visible/near-infrared absorption spectroscopy, grazing incidence X-ray diffractometry, polarized Fourier transform infrared spectroscopy (FT-IR), and infrared p-polarized multiple-angle incidence resolution spectroscopy (pMAIRS). The F4TCNQ-doped 3D oriented P3HT films showed anisotropic properties in all characterizations. In particular, the anisotropic molecular vibrations from polarized FT-IR and pMAIRS have clearly revealed orientations of polymeric chains and molecular dopant molecules. Considering the results from several independent techniques indicated that F4TCNQ anions in the 3D oriented P3HT were orderly arranged in a 3D manner with respect to the 3D oriented P3HT such that their molecular long-axis parallel to the P3HT backbone, with in-plane molecular orientation. Additionally, the direction of the optical transition moment of the F4TCNQ anion was found to be parallel to the molecular short-axis.
PRMT1 inhibition induces differentiation of colon cancer cells
Authors: Plotnikov Alexander , Kozer Noga , Cohen Galit , Carvalho Silvia , Duberstein Shirly , Almog Ofir , Solmesky Leonardo Javier , Shurrush Khriesto A. , Babaev Ilana , Benjamin Sima , Gilad Shlomit , Kupervaser Meital , Levin Yishai , Gershovits Michael , Ben-Avraham Danny , Barr Haim Michael 
Published: November 2020

AbstractDifferentiation therapy has been recently revisited as a prospective approach in cancer therapy by targeting the aberrant growth, and repairing the differentiation and cell death programs of cancer cells. However, differentiation therapy of solid tumors is a challenging issue and progress in this field is limited. We performed High Throughput Screening (HTS) using a novel dual multiplex assay to discover compounds, which induce differentiation of human colon cancer cells. Here we show that the protein arginine methyl transferase (PRMT) type 1 inhibitor, MS023, is a potent inducer of colon cancer cell differentiation with a large therapeutic window. Differentiation changes in the highly aggressive human colon cancer cell line (HT-29) were proved by proteomic and genomic approaches. Growth of HT-29 xenograft in nude mice was significantly delayed upon MS023 treatment and immunohistochemistry of tumor indicated differentiation changes. These findings may lead to development of clinically effective anti-cancer drugs based on the mechanism of cancer cell differentiation.
Hop bitter acids containing a β-carbonyl moiety prevent inflammation-induced cognitive decline via the vagus nerve and noradrenergic system
Authors: Ano Yasuhisa , Ohya Rena , Yamazaki Takahiro , Takahashi Chika , Taniguchi Yoshimasa , Kondo Keiji , Takashima Akihiko , Uchida Kazuyuki , Nakayama Hiroyuki 
Published: November 2020

AbstractThe prevention of age-related cognitive decline and dementia is becoming a high priority because of the rapid growth of aging populations. We have previously shown that hop bitter acids such as iso-α-acids (IAAs) and matured hop bitter acids (MHBAs) activate the vagus nerve and improve memory impairment. Moreover, supplements with MHBAs were shown to improve memory retrieval in older adults. However, the underlying mechanisms have not been entirely elucidated. We aimed to investigate the effects of MHBAs and the common β-tricarbonyl moiety on memory impairment induced by the activation of microglia and the loss of the noradrenergic system. MHBAs and a model compound with β-tricarbonyl moiety were administered to LPS-inoculated mice and 5 × FAD Alzheimer’s disease (AD) model mice, following the evaluation in behavioral tests and microglial activation. To evaluate the association of noradrenaline with MHBAs effects, mice treated with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4), a noradrenergic neurotoxin that selectively damages noradrenergic projections from the locus coeruleus, were subjected to the behavioral evaluation. MHBAs reduced brain inflammation and improved LPS-induced memory impairment. A model compound possessing the β-tricarbonyl moiety improved the LPS-induced memory impairment and neuronal loss via the vagus nerve. Additionally, the protective effects of MHBAs on memory impairment were attenuated by noradrenaline depletion using DSP-4. MHBAs suppressed the activation of microglia and improved the memory impairment in 5 × FAD mice, which was also attenuated by noradrenaline depletion. Treatment with MHBAs increased cholecystokinin production from the intestinal cells. Generally, cholecystokinin activates the vagal nerve, which stimulate the noradrenergic neuron in the locus ceruleus. Taken together, our results reveal that food ingredients such as hop bitter acids with a β-tricarbonyl moiety suppress microglial activation and improve memory impairment induced by inflammation or AD pathology via the activation of the gut-brain axis and noradrenergic system. Supplements with hop bitter acids, including MHBAs, might be a novel approach for the prevention of cognitive decline and dementia.
Open-label placebos for menopausal hot flushes: a randomized controlled trial
Authors: Pan Yiqi , Meister Ramona , Löwe Bernd , Kaptchuk Ted J. , Buhling Kai J. , Nestoriuc Yvonne 
Published: November 2020

AbstractThis study investigated the efficacy of an open-label placebo (OLP) treatment for menopausal hot flushes. Women with at least five moderate or severe hot flushes per day were allocated to receive four weeks of OLP for twice a day or no-treatment. Intention-to-treat analyses included n = 100 women. In comparison to no-treatment, OLP reduced the log-transformed hot flush composite score (frequency × intensity) (mean difference in change: − 0.32, 95% CI [− 0.43; − 0.21], p < 0.001, Cohen’s d = 0.86), hot flush frequency (− 1.12 [− 1.81; − 0.43], p = 0.02, Cohen’s d = 0.51), and improved overall menopause-related quality of life (− 2.53 [− 4.17; − 0.89], p = 0.02, Cohen’s d = 0.49). Twelve (24%) (vs. three [6%]) patients had 50% lesser hot flushes. Problem rating of hot flushes and subdomains of quality of life did not improve. After four weeks, the OLP group was further divided via randomization to continue or discontinue the treatment. Benefits were maintained at week 8 (log-transformed score: − 0.04 [− 0.06; 0.14], p = 0.45). There was no difference between taking placebos for 8 or 4 weeks (log-transformed score: 0.04 [− 0.17; 0.25], p = 0.73). Results indicate that open-label placebos may be an effective, safe alternative for menopausal hot flushes.
In-plane β-Co(OH)2/Co3O4hybrid nanosheets for flexible all-solid-state thin-film supercapacitors with high electrochemical performance
Authors: Lou Shanshan , Yang Xueying , Hao Pin , Lei Fengcai , Xie Junfeng , Tang Bo 
Published: November 2020

In-plane β-Co(OH)2/Co3O4 hybrid nanosheets with porous surface and controllable composition were fabricated as efficient electrode materials for the all-solid-state thin-film supercapacitors (ASSTFSs).
The LOFAR Two-meter Sky Survey: Deep Fields Data Release 1
Authors: Kondapally R. , Best P. N. , Hardcastle M. J. , Nisbet D. , Bonato M. , Sabater J. , Duncan K. J. , McCheyne I. , Cochrane R. K. , Bowler R. A. A. , Williams W. L. , Shimwell T. W. , Tasse C. , Croston J. H. , Goyal A. , Jamrozy M. , Jarvis M. J. , Mahatma V. H. , Röttgering H. J. A. , Smith D. J. B. , Wołowska A. , Bondi M. , Brienza M. , Brown M. J. I. , Brüggen M. , Chambers K. , Garrett M. A. , Gürkan G. , Huber M. , Kunert-Bajraszewska M. , Magnier E. , Mingo B. , Mostert R. , Nikiel-Wroczyński B. , O’Sullivan S. P. , Paladino R. , Ploeckinger T. , Prandoni I. , Rosenthal M. J. , Schwarz D. J. , Shulevski A. , Wagenveld J. D. , Wang L. 
Published: November 2020

We present the source associations, cross-identifications, and multi-wavelength properties of the faint radio source population detected in the deep tier of the LOFAR Two Metre Sky Survey (LoTSS): the LoTSS Deep Fields. The first LoTSS Deep Fields data release consists of deep radio imaging at 150 MHz of the ELAIS-N1, Lockman Hole, and Boötes fields, down to RMS sensitives of around 20, 22, and 32 μJy beam−1, respectively. These fields are some of the best studied extra-galactic fields in the northern sky, with existing deep, wide-area panchromatic photometry from X-ray to infrared wavelengths, covering a total of ≈26 deg2. We first generated improved multi-wavelength catalogues in ELAIS-N1 and Lockman Hole; combined with the existing catalogue for Boötes, we present forced, matched aperture photometry for over 7.2 million sources across the three fields. We identified multi-wavelength counterparts to the radio detected sources, using a combination of the Likelihood Ratio method and visual classification, which greatly enhances the scientific potential of radio surveys and allows for the characterisation of the photometric redshifts and the physical properties of the host galaxies. The final radio-optical cross-matched catalogue consists of 81 951 radio-detected sources, with counterparts identified and multi-wavelength properties presented for 79 820 (>97%) sources. We also examine the properties of the host galaxies, and through stacking analysis find that the radio population with no identified counterpart is likely dominated by active galactic nuclei (AGN) atz~ 3−4. This dataset contains one of the largest samples of radio-selected star-forming galaxies and AGN at these depths, making it ideal for studying the history of star-formation, and the evolution of galaxies and AGN across cosmic time.
Association between Adherence with an Atypical Antipsychotic and with
Other Psychiatric Drugs in Patients with Bipolar Disorder
Authors: Bauer Michael , Glenn Tasha , Alda Martin , Grof Paul , Monteith Scott , Rasgon Natalie , Severus Emanuel , Whybrow Peter C. 
Published: November 2020

Abstract
Background Using U.S. pharmacy and medical claims, medication
adherence patterns of patients with serious mental illness suggest that
adherence to atypical antipsychotics may be related to adherence to other
prescription drugs. This study investigated whether adherence to an atypical
antipsychotic was related to adherence to other prescribed psychiatric drugs
using self-reported data from patients with bipolar disorder.
Methods Daily self-reported medication data were available from 123
patients with a diagnosis of bipolar disorder receiving treatment as usual
who took at least 1 atypical antipsychotic over a 12-week period. Patients
took a mean of 4.0±1.7 psychiatric drugs including the
antipsychotic. The adherence rate for the atypical antipsychotic was
compared to that for other psychiatric drugs to determine if the adherence
rate for the atypical antipsychotic differed from that of the other
psychiatric drug by at least ±10%.
Results Of the 123 patients, 58 (47.2%) had an adherence rate
for the atypical antipsychotic that differed from the adherence rate for at
least 1 other psychiatric drug by at least±10%, and 65
(52.8%) patients had no difference in adherence rates. The patients
with a difference took a larger total number of psychiatric drugs
(p<0.001), had a larger daily pill burden (p=0.020) and a
lower adherence rate with the atypical antipsychotic (p=0.007), and
were more likely to take an antianxiety drug (p<0.001).
Conclusion Adherence with an atypical antipsychotic was not useful for
estimating adherence to other psychiatric drugs in about half of the
patients with bipolar disorder.
Copper/GanPhos-Catalyzed 1,3-Dipolar Cycloaddition of Azo­methine Ylides: An Efficient Access to Chiral Pyrrolidine Spirocycles
Authors: Gan Zhenjie , Li Er-Qing , Li Ke , Zhang Hui 
Published: November 2020

AbstractA highly efficient copper/GanPhos-catalyzed 1,3-dipolar cyclo­addition­ of azomethine ylides is reported. This viable transformation provides a series of optically active spiro[dihydronaphthalene-2,3′-pyrrolidine]s, bearing one spiro quaternary and three tertiary stereogenic centers, in good yields and with high ee values. This protocol features high diastereo- and enantioselectivity, broad substrate scope and mild reaction conditions.
Simple Interrupted Microvascular Anastomosis: Review of Four Sutures Placement Sequences
Authors: Sullivan Brianne , Zoppo Michael , Yao Alice , Henderson Peter W. 
Published: November 2020

Abstract
Background Microsurgical anastomosis is a delicate, highly nuanced procedure that can be done in several different ways; the most basic approach to performing microsurgical anastomoses is by using simple interrupted sutures, but even within that approach, there are different sequences by which the sutures can be placed. To date, there is no review of these sequences and the advantages and disadvantages of each.
Methods A PubMed search was performed in October 2019 that sought all published descriptions of simple interrupted microsurgery techniques. Keywords included were “microvascular anastomosis,” “microvascular anastomosis technique,” “simple interrupted,” and “microsurgery.”
Results Four simple interrupted microsurgery techniques were identified: triangulation, 12 o'clock to 6 o'clock, posterior-wall-first, and 3 o'clock to 9 o'clock-side-side. Additionally, there is no uniform nomenclature that describes the techniques for simple interrupted microvascular anastomoses.
Conclusion This study identified four distinct sequences for the placement of simple interrupted sutures for microsurgical anastomosis and the advantages and disadvantages of each, and for the first time described them utilizing standardized nomenclature.
Bleeding with Apixaban and Dalteparin in Patients with Cancer-Associated Venous Thromboembolism: Results from the Caravaggio Study
Authors: Ageno Walter , Vedovati Maria Cristina , Cohen Ander , Huisman Menno , Bauersachs Rupert , Gussoni Gualberto , Becattini Cecilia , Agnelli Giancarlo 
Published: November 2020

Abstract
Background Direct oral anticoagulants are recommended for the treatment of cancer-associated thrombosis (CAT) as an alternative to low-molecular-weight heparin (LMWH), but an increased bleeding risk in patients with gastrointestinal cancer was reported. The Caravaggio study compared apixaban and dalteparin for the treatment of patients with CAT. Here we describe sites of bleeding, associated cancer sites, clinical presentation, and course of major bleeding in patients included in the Caravaggio study.
Methods The Caravaggio study was a multinational, randomized, open-label, noninferiority study. Bleeding events and the severity of major bleedings were adjudicated by a committee unaware of treatment allocation using predefined criteria; for the purpose of this analysis, data were analyzed in the safety population.
Results Major bleeding occurred in 22 of 576 patients on apixaban (3.8%) and in 23 of 579 patients on dalteparin (4.0%). The sites of major bleeding and their distribution according to the type of cancer were similar between the two treatment groups. Major bleeding occurred in nine patients with gastrointestinal cancer in each treatment group. The clinical presentation of major bleeding was severe or fatal in 6 patients on apixaban and in 5 patients on dalteparin, while the clinical course was severe in 5 patients on apixaban and in 7 patients on dalteparin.
Conclusion Apixaban is a safe alternative to LMWH for the treatment in patients with CAT. No excess in gastrointestinal bleeding was observed in patients who received apixaban, including those with gastrointestinal cancer.
A numerical stability analysis for the Einstein–Vlasov system
Authors: Günther Sebastian , Körner Jacob , Lebeda Timo , Pötzl Bastian , Rein Gerhard , Straub Christopher , Weber Jörg 
Published: November 2020

Abstract
We investigate stability issues for steady states of the spherically symmetric Einstein–Vlasov system numerically in Schwarzschild, maximal areal, and Eddington–Finkelstein coordinates. Across all coordinate systems we confirm the conjecture that the first binding energy maximum along a one-parameter family of steady states signals the onset of instability. Beyond this maximum perturbed solutions either collapse to a black hole, form heteroclinic orbits, or eventually fully disperse. Contrary to earlier research, we find that a negative binding energy does not necessarily correspond to fully dispersing solutions. We also comment on the so-called turning point principle from the viewpoint of our numerical results. The physical reliability of the latter is strengthened by obtaining consistent results in the three different coordinate systems and by the systematic use of dynamically accessible perturbations.
Examining the production of some bands of the electromagnetic spectrum using KCl
Authors: Pilakouta M , Sianoudis J , Giannouri M 
Published: November 2020

Abstract
An experimental activity for teaching the origin of some bands of the electromagnetic spectrum using only one substance is presented. The activity is proposed for undergraduate students and focuses on developing their knowledge on the origin and the specific requirements for excitation and detection of three bands of the electromagnetic spectrum, in a comparative way. In this teaching approach, gamma rays from spontaneous emission of 40K, x-rays and visible radiation emission after appropriate excitation of KCl, is detected using instruments that can be found in an undergraduate physics and chemistry laboratory. The activity which combines demonstration and student engagement is described and the results related to the examination of each band are discussed.
Improved content mastery and written communication through a lab-report assignment with peer review: an example from a quantum engineering course
Authors: Bylander Jonas , Gustafsson Magnus 
Published: November 2020

Abstract
The promotion of high-quality written communication in the disciplines is an important learning outcome in higher education. Given the time invested by students and teachers alike, it is crucial that writing assignments also promote engagement and content learning. But is it worth the time for university teachers to invest in such ‘writing-to-learn’ activityes? We find that it can be, and present an improved design for an experimental lab-report writing assignment in an English medium instruction environment, where English is an additional language. Our context is assignment development for formative assessment in master’s-level physics, but the method is broadly applicable within the science-technology-engineering-math disciplines. Our first experience with the assignment resulted in substandard lab reports, suggesting insufficient subject understanding and prompting this assignment design. We therefore focused on communicating the alignment of aims, learning objectives, instruction, assessment criteria, and feedback design, and developed simplified rubrics facilitating assessment fairness and efficiency. The revised assignment enhanced the learning of the subject matter and the writing quality over the four years of the study, indicated by clearly improved reports and relevant peer feedback comments. The learning activity also had an observable but less distinct effect on the students’ exam performance.
Floating of a long square bar: experiment vs theory
Authors: Feigel Yonatan , Fuzailov Nikita 
Published: November 2020

Abstract
We carried out an experimental study of the floating of a square bar in water and found its equilibrium orientation (tilting angle) as a function of relative density ρ
bar/ρ
water. Though the theoretical solution of this problem was given in 1963 by Reid, we provided our solution that is more transparent and less cumbersome, enabling an introductory level physics student to follow it. Our experimental method is very simple and easily reproducible in a school-level physics laboratory, and obtained data fit the theoretical results quite reasonably.
Source method for the evaluation of multipole fields
Authors: Pitombo R S , Vasconcellos M , Farina C , de Melo e Souza Reinaldo 
Published: November 2020

Abstract
The multipole expansion is an approximation technique useful whenever one wishes to obtain the electromagnetic fields far away from the sources. Here we present an alternative way to perform the multipole expansion which is more economic than usual treatments, specially in time-dependent situations. This method is based on a Taylor expansion directly on the sources (charge and current distributions), instead of the usually performed expansion on the fields. We apply this source method to calculate explicitly the complete fields of an arbitrary time dependent point magnetic dipole and point electric quadrupole.
Thin film transistors integrating CsPbBr3 quantum dots for optoelectronic memory application
Authors: Wen Jiamin , Hu Hao , Wen Guohao , Wang Shuhan , Sun Zhenhua , Ye Shuai 
Published: November 2020

Abstract
All-inorganic perovskite cesium lead bromide (CsPbBr3) quantum dots (QDs) have been used as charge storage centers in floating-gate transistors. In this work, CsPbBr3 QDs are integrated into thin film transistors to create transistor-based memory. Unlike the floating-gate transistors previously reported, the CsPbBr3 QDs are placed between the dielectric and semiconductor layer, leading to direct contact with the semiconductor layer. Characterization of the device performance reveals that the CsPbBr3 QDs exhibit a strong tendency to store holes instead of electrons. Analysis unravels that this property possibly comes from the junction formed between the CsPbBr3 QDs and the transistor’s semiconductor layer, which can facilitate hole injection from the semiconductor layer to the QDs under a negative gate bias, as well as the storage of the injected holes in the QDs. Devices using an organic semiconductor (P3HT) or two-dimensional material (graphene) consistently verify this speculation. Benefiting from the hole storage ability of the CsPbBr3 QDs, these devices show a benign non-volatile memory feature. As transistor-based memories, these devices can be programmed by electricity and erased by electricity or light illumination, rendering them as capable of optoelectronic memory application. This work offers an alternative approach for novel transistor-based optoelectronic memory.
Pionless effective field theory evaluation of nuclear polarizability in muonic deuterium
Authors: Emmons Samuel B , Ji Chen , Platter Lucas 
Published: November 2020

Abstract
We calculate the longitudinal structure function of the deuteron up through next-to-next-to-leading order in the framework of pionless effective field theory. We use these results to compute the two-photon polarizability contribution to Lamb shift in muonic deuterium, which can be utilized to extract the nuclear charge radius of the deuteron. We present analytical expressions order-by-order for the relevant transition matrix elements and the longitudinal structure function, and we give numerical results for the corresponding contributions to the Lamb shift. We also discuss the impact of relativistic and other higher-order effects. We find agreement with previous calculations and explain the accuracy of our calculation.