bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tibiopedal and distal femoral retrograde vascular access for challenging chronic total occlusions: predictors for technical success, and complication rates in a large single-center cohort
Authors: Grözinger Gerd , Hallecker Jan , Grosse Ulrich , Syha Roland , Ketelsen Dominik , Brechtel Klaus , Lescan Mario , Nikolaou Konstantin , Artzner Christoph 
Published: July 2020

Abstract
Objective
To evaluate the safety and effectiveness of tibiopedal and distal femoral access for retrograde crossing of chronic total occlusion (CTO) in Rutherford stage III to VI peripheral arterial occlusive disease, and to determine factors that correlate with technical success.

Material and methods
One hundred seventy-one consecutive patients were included in this retrospective study. Rutherford stages were III, IV, and V/VI in 24%, 8%, and 67% of patients. Inclusion criteria were CTO at the superficial femoral (SFA), popliteal (PA), and/or below-the-knee (BTK) level, and a failed antegrade treatment followed by a distal retrograde approach. The numbers of occluded vascular levels (OVL), lesion length, degree of calcification, technical success rate, complications, and clinical outcome were noted.

Results
OVL were 1 in 72%, 2 in 20%, and 3 in 8% of patients. CTOs were longer than 20 cm in 45.6% of cases and showed severe calcifications in 50.3%. Target vessels for distal access were the distal SFA/PA in 17% and BTK in 83%. The overall technical success rate was 82%. Severe calcification decreased technical success (p = 0.01) despite lesion length and Rutherford stage. Clinical outcome improved in 123/152 patients with a significant increase of the median ABI (N = 158) from 0.53 (interquartile range 0.39 to 0.61) to 0.85 (0.59 to 1.03; p < 0.001). Complications were reported in 7.6% cases with 2.3% related to the distal vascular access.

Conclusion
The tibiopedal and distal femoral retrograde access presents a safe and effective treatment option of CTOs at the thigh and/or BTK after a failed antegrade attempt improving clinical outcome. Technical success decreased with lesion’s degree of calcification.

Key Points
• Safety and effectiveness of the tibiopedal and distal femoral access for retrograde crossing of chronic total occlusion.
• Target lesion’s degree of calcification decreases technical success.
• Complications related to the distal vascular access were rare.
Efficient image dataset classification difficulty estimation for predicting deep-learning accuracy
Authors: Scheidegger Florian , Istrate Roxana , Mariani Giovanni , Benini Luca , Bekas Costas , Malossi Cristiano 
Published: July 2020

AbstractIn the deep-learning community, new algorithms are published at a very fast pace. Therefore, solving an image classification problem for new datasets becomes a challenging task, as it requires to re-evaluate published algorithms and their different configurations in order to find a close to optimal classifier. To facilitate this process, before biasing our decision toward a class of neural networks or running an expensive search over the network space, we propose to estimate the classification difficulty of the dataset. Our method computes a single number that characterizes the dataset difficulty$$97\times $$97×faster than training state-of-the-art networks. The proposed method can be used in combination with network topology and hyper-parameter search optimizers to efficiently drive the search toward promising neural network configurations.
The influence of fish consumption on serum n-3 polyunsaturated fatty acid (PUFA) concentrations in women of childbearing age: a randomised controlled trial (the iFish Study)
Authors: Conway Marie C. , McSorley Emeir M. , Mulhern Maria S. , Spence Toni , Wijngaarden Edwin van , Watson Gene E. , Wahlberg Karin , Pineda Daniela , Broberg Karin , Hyland Barry W. , Cobice Diego F. , Strain J. J. , Yeates Alison J. 
Published: July 2020

Abstract
Purpose
Long-chain polyunsaturated fatty acids (LCPUFA) can be synthesised endogenously from linoleic acid (LA) and α-linolenic acid (ALA) in a pathway involving the fatty acid desaturase (FADS) genes. Endogenous synthesis is inefficient; therefore, dietary intake of preformed LCPUFA from their richest source of fish is preferred. This study investigated the effect of fish consumption on PUFA concentrations in women of childbearing age while stratifying by FADS genotype. The influence of fish consumption on lipid profile, and markers of inflammation and oxidative stress was also examined.

Methods
Healthy women (n = 49) provided a buccal swab which was analysed for FADS2 genotype (rs3834458; T/deletion). Participants were stratified according to genotype and randomised to an intervention group to receive either no fish (n = 18), 1 portion (n = 14) or 2 portions (n = 17) (140 g per portion) of fish per week for a period of 8 weeks. Serum PUFA was analysed at baseline and post-intervention. Lipid profile, and markers of inflammation and oxidative stress were also analysed.

Results
Participants consuming 2 portions of fish per week had significantly higher concentrations of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and total n-3 PUFA, and a lower n-6:n-3 ratio compared to those in the no fish or 1 portion per week group (all p < 0.05). Fish consumption did not have a significant effect on biomarkers of oxidative stress, inflammation and lipid profile in the current study.

Conclusion
Consumption of 2 portions of fish per week has beneficial effects on biological n-3 PUFA concentrations in women of childbearing age; however, no effects on oxidative stress, inflammation or lipid profile were observed. This trial was registered at www.clinicaltrials.gov (NCT03765580), registered December 2018.
Psychological consequences of COVID-19 pandemic in Italian MS patients: signs of resilience?
Authors: Capuano Rocco , Altieri Manuela , Bisecco Alvino , d’Ambrosio Alessandro , Docimo Renato , Buonanno Daniela , Matrone Federica , Giuliano Federica , Tedeschi Gioacchino , Santangelo Gabriella , Gallo Antonio 
Published: July 2020

Abstract
Background
Anxiety, depression and reduction of quality of life (QoL) are common in people with multiple sclerosis (pwMS). Fear of getting sick from COVID-19, government’s lockdown and the imposed social distancing might have had an impact on psychological distress and QoL.

Objectives
The aim of our study was to investigate anxiety, depression and QoL changes in pwMS during SARS-CoV-2 outbreak and lockdown in Italy.

Methods
67 pwMS with a previous (less than 6 months) neuropsychological evaluation before SARS-CoV-2 outbreak (T0) were re-evaluated at the time of the outbreak and lockdown in Italy (T1). They underwent a clinical and neurological evaluation and completed the State-Trait Anxiety Inventory (STAI-Y1), the Beck Depression Inventory second edition (BDI-II), and Multiple Sclerosis Quality of Life-54 (MsQoL-54) at T0 and T1. Benjamini–Hochberg procedure was applied to control the false discovery rate.

Results
BDI-II and STAI-Y1 scores did not change between T0 and T1. At T1, MsQoL-54 scores were higher on the satisfaction with sexual life and the social function subscales, and lower on the limitation due to emotional problems subscale.

Conclusions
This is the first study that evaluated mood and QoL levels before and during the lockdown due to COVID-19 pandemic in pwMS. No worsening of anxiety and depression levels was found. Contrariwise some improvements were noted on QoL, the most reliable regarding the sexual satisfaction and the social function.
Transepithelial corneal cross-linking assisted by two continuous cycles of iontophoresis for progressive keratoconus in adults: retrospective 5-year analysis
Authors: Wu Huping , Luo Shunrong , Fang Xie , Shang Xumin , Xie Zhiwen , Xiao Xianwen , Lin Zhirong , Liu Zuguo 
Published: July 2020

Abstract
Purpose
The aim of this study is to compare the long-term effects of transepithelial corneal crosslinking with two continuous cycles of iontophoresis (EI-CXL) and conventional corneal crosslinking (C-CXL) in adults with progressive keratoconus.

Methods
A retrospective analysis was conducted in adults who underwent C-CXL or EI-CXL between 2013 and 2015. Visual acuity, corneal tomography, anterior segment optical coherence tomography, in vivo corneal confocal microscopy (IVCM), and endothelial cell count (ECC) were performed preoperatively and 5 years postoperatively.

Results
Sixty-eight patients with a mean age of (24.3 ± 3.8) years were included, 34 for each group. After CXL, UCVA or BCVA remained stable, while the spherical diopter, cylinder diopter, spherical equivalent, and Kmax significantly decreased at 1, 2, and 3 years in both groups than baseline (P < 0.05). No significant differences were found in any refractive or tomographic parameters as well as the minimal corneal thickness between groups during follow-up. At 5 years, Kmax was slightly higher in EI-CXL group (58.16 ± 6.28) than that of C-CXL group (57.46 ± 4.98). At 3 and 5 years, the minimal corneal thickness in C-CXL group was still significantly lower than baseline (P < 0.05). IVCM demonstrated the demarcation zone at a mean depth of (302.0 ± 41.7) μm after C-CXL, and at (251.2 ± 28.1) μm after EI-CXL (P < 0.001). Keratocyte repopulation was detectable at all follow-up timepoint in both groups. Postoperative complications including progression were recorded in 6 patients (11.7%) after C-CXL and 3 patients (8.8%) after EI-CXL. ECC remained stable in both groups.

Conclusion
EI-CXL showed approximate efficacy with C-CXL in stabilizing progressive keratoconus in adults. EI-CXL has the potential to be a preferable transepithelial protocol.
Elevation of phosphate levels impairs skeletal myoblast differentiation
Authors: Raimann Adalbert , Dangl Alexander , Javanmardi Alireza , Greber-Platzer Susanne , Egerbacher Monika , Pietschmann Peter , Haeusler Gabriele 
Published: July 2020

AbstractHyperphosphatemic conditions such as chronic kidney disease are associated with severe muscle wasting and impaired life quality. While regeneration of muscle tissue is known to be reliant on recruitment of myogenic progenitor cells, the effects of elevated phosphate loads on this process have not been investigated in detail so far. This study aims to clarify the direct effects of hyperphosphatemic conditions on skeletal myoblast differentiation in a murine in vitro model. C2C12 murine muscle progenitor cells were supplemented with phosphate concentrations resembling moderate to severe hyperphosphatemia (1.4–2.9 mmol/l). Phosphate-induced effects were quantified by RT-PCR and immunoblotting. Immunohistochemistry was performed to count nuclear positive cells under treatment. Cell viability and metabolic activity were assessed by XTT and BrdU incorporation assays. Inorganic phosphate directly induced ERK-phosphorylation in pre-differentiated C2C12 myoblast cells. While phosphate concentrations resembling the upper normal range significantly reduced Myogenin expression (− 22.5%, p = 0.015), severe hyperphosphatemic conditions further impaired differentiation (Myogenin − 61.0%, p < 0.0001; MyoD − 51.0%; p < 0.0001). Analogue effects were found on the protein level (Myogenin − 42.0%, p = 0.004; MyoD − 25.7%, p = 0.002). ERK inhibition strongly attenuated phosphate-induced effects on Myogenin expression (p = 0.002). Metabolic activity was unaffected by the treatments. Our data point to a phosphate-induced inhibition of myoblast differentiation without effects on cell viability. Serum phosphate levels as low as the upper normal serum range significantly impaired marker gene expression in vitro. Investigation of cellular effects of hyperphosphatemia may help to better define serum cutoffs and modify existing treatment approaches of phosphate binders, especially in patients at risk of sarcopenia.
Lower semicontinuity and relaxation of nonlocal $$L^\infty $$-functionals
Authors: Kreisbeck Carolin , Zappale Elvira 
Published: July 2020

AbstractWe study variational problems involving nonlocal supremal functionals$$\begin{aligned} L^\infty (\Omega ;{\mathbb {R}}^m) \ni u\mapsto \mathrm{ess sup}_{(x,y)\in \Omega \times \Omega } W(u(x), u(y)), \end{aligned}$$L∞(Ω;Rm)∋u↦esssup(x,y)∈Ω×ΩW(u(x),u(y)),where$$\Omega \subset \mathbb {R}^n$$Ω⊂Rnis a bounded, open set and$$W:\mathbb {R}^m\times \mathbb {R}^m\rightarrow \mathbb {R}$$W:Rm×Rm→Ris a suitable function. Motivated by existence theory via the direct method, we identify a necessary and sufficient condition for$$L^\infty $$L∞-weak$$^*$$∗lower semicontinuity of these functionals, namely, separate level convexity of a symmetrized and suitably diagonalized version of the supremands. More generally, we show that the supremal structure of the functionals is preserved during the process of relaxation. The analogous statement in the related context of double-integral functionals was recently shown to be false. Our proof relies substantially on the connection between supremal and indicator functionals. This allows us to recast the relaxation problem into characterizing weak$$^*$$∗closures of a class of nonlocal inclusions, which is of independent interest. To illustrate the theory, we determine explicit relaxation formulas for examples of functionals with different multi-well supremands.
An andesitic sill complex in the Southern Permian Basin: volcanogenetic model and stratigraphic implications
Authors: Luthardt Ludwig , Breitkreuz Christoph , Schneider Joerg W. , Gaitzsch Birgit , Brink Judith , Stanek Klaus Peter , Linnemann Ulf , Hofmann Mandy , Ehling Bodo-Carlo 
Published: July 2020

AbstractSubvolcanic intrusions are highly variable in shape and structure, and occur in nearly all parts of the upper crust, as a result of extensive volcanic activity. Processes of subvolcanics interacting with the host rock are insufficiently understood, as they are rarely exposed. In the southernmost part of the Flechtingen-Altmark Subprovince, (sub)volcanic rocks of the Flechtingen Volcanic Complex (FVC) are exposed in several quarries. It is built up of silicic tuffs, ignimbrites and lava flows, but also of intermediate lavas and extended sill sheets. Additionally, major granitic intrusions exposed by drillings are associated with the FVC. In the Mammendorf quarry, a sill intruded in between lithified turbiditic series of early Carboniferous (Visean–Serphukovian) age at the base, and widely consolidated volcanoclastic deposits of late Carboniferous (late Pennsylvanian) age at the top. Various magma-host rock interactions were found indicating brittle and ductile deformation patterns occurring at the basal contact, and secondary fluidal mixing predominantly occurring at the top contact, most probably caused by fluids accompanying the intruding magma. We present an extended volcanogenetic model for the FVC. Volcanic activity initiated at 302 ± 3 Ma with fallout deposits represented by mostly re-deposited silicic ashfall deposits of the Flechtingen Formation, and cumulated in depositing major ignimbrite series, most likely forming a caldera. Later, the sills intruded at the rheological boundary of the lithified Mississippian turbiditic series and the partly consolidated volcanoclastic series. Finally, major granitic intrusions emplaced in the basement rocks at around 298 ± 4 Ma. The study contributes to clarify stratigraphic constraints of late Carboniferous to early Permian continental deposits and sheds light on stratigraphy of significant late Paleozoic volcanic deposits of the Flechtingen-Altmark Subprovince in the Southern Permian Basin.
COVID-19 and Economic Growth: Does Good Government Performance Pay Off?
Authors: König Michael , Winkler Adalbert 
Published: July 2020

AbstractThe coronavirus pandemic led to substantial revisions of 2020 GDP growth projections. We analyse whether and to what extent the quality of government policies in handling the health aspects of the crisis influence cross-country differences in the economic impact of the pandemic as projected by the OECD, the IMF and the World Bank. We measure policy quality by a recently published Economist Intelligence Unit index and a COVID-19 Misery index combining the stringency of government-imposed distancing measures with the COVID-19 fatality rate. Moreover, we control for international spillovers captured by trade openness and export exposure to tourism. Results for most specifications show that good government performance pays off as the respective countries record less severe revisions of growth forecasts. Only in a few cases, our findings suggest that the pandemic’s global effect might be so strong that actions by individual governments do not affect cross-country differences of growth revisions. Finally, there is broad evidence supporting the view that a country’s exposure to the global economy influences its growth outlook relative to other countries.
Detection of early cartilage degeneration in the tibiotalar joint using 3 T gagCEST imaging: a feasibility study
Authors: Abrar Daniel B. , Schleich Christoph , Radke Karl Ludger , Frenken Miriam , Stabinska Julia , Ljimani Alexandra , Wittsack Hans-Jörg , Antoch Gerald , Bittersohl Bernd , Hesper Tobias , Nebelung Sven , Müller-Lutz Anja 
Published: July 2020

Abstract
Objective
To establish and optimize a stable 3 Tesla (T) glycosaminoglycan chemical exchange saturation transfer (gagCEST) imaging protocol for assessing the articular cartilage of the tibiotalar joint in healthy volunteers and patients after a sustained injury to the ankle.

Methods
Using Bloch–McConnell simulations, we optimized the sequence protocol for a 3 T MRI scanner for maximum gagCEST effect size within a clinically feasible time frame of less than 07:30 min. This protocol was then used to analyze the gagCEST effect of the articular cartilage of the tibiotalar joint of 17 healthy volunteers and five patients with osteochondral lesions of the talus following ankle trauma. Reproducibility was tested with the intraclass correlation coefficient.

Results
The mean magnetization transfer ratio asymmetry (MTRasym), i.e., the gagCEST effect size, was significantly lower in patients than in healthy volunteers (0.34 ± 1.9% vs. 1.49 ± 0.11%; p < 0.001 [linear mixed model]). Intra- and inter-rater reproducibility was excellent with an average measure intraclass correlation coefficient (ICC) of 0.97 and a single measure ICC of 0.91 (p < 0.01).

Discussion
In this feasibility study, pre-morphological tibiotalar joint cartilage damage was quantitatively assessable on the basis of the optimized 3 T gagCEST imaging protocol that allowed stable quantification gagCEST effect sizes across a wide range of health and disease in clinically feasible acquisition times.
Effects of Shinrin-Yoku (Forest Bathing) and Nature Therapy on Mental Health: a Systematic Review and Meta-analysis
Authors: Kotera Yasuhiro , Richardson Miles , Sheffield David 
Published: July 2020

AbstractShinrin-yoku, immersing oneself in nature using one’s senses, has been receiving increased attention internationally. While most of the existing studies have focused on physical health, this systematic review and meta-analysis examined the mental health impacts of shinrin-yoku, using the PRISMA guidelines (PROSPERO registry: BLINDED). Of 497 articles retrieved on databases including PubMed/MEDLINE, PsycINFO, Science Direct and Google Scholar, twenty met the inclusion criteria. All studies were conducted in Asia and Europe, and used a variety of different bathing approaches (e.g. breathing, walking, yoga). While noting a need for more rigorous research and extensive follow-up assessments, the findings indicate that shinrin-yoku can be effective in reducing mental health symptoms in the short term, particularly anxiety. More careful examination of shinrin-yoku practices is needed; longer follow-up with participants from a range of countries along with greater examination of potential mechanisms is needed for shinrin-yoku to be accepted into mainstream interventions.
Umbilical Cord Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis: an Original Study
Authors: Barczewska Monika , Maksymowicz Stanisław , Zdolińska-Malinowska Izabela , Siwek Tomasz , Grudniak Mariusz 
Published: July 2020

Abstract
Objective
Amyotrophic lateral sclerosis (ALS) is still incurable. Although different therapies can affect the health and survival of patients. Our aim is to evaluate the effect of umbilical mesenchymal stem cells administrated intrathecally to patients with amyotrophic lateral sclerosis on disability development and survival.

Methods
This case-control study involved 67 patients treated with Wharton’s jelly mesenchymal stem cells (WJ-MSC). The treated patients were paired with 67 reference patients from the PRO-ACT database which contains patient records from 23 ALS clinical studies (phase 2/3). Patients in the treatment and reference groups were fully matched in terms of race, sex, onset of symptoms (bulbar/spinal), FT9 disease stage at the beginning of therapy and concomitant amyotrophic lateral sclerosis medications. Progression rates prior to treatment varied within a range of ± 0.5 points. All patients received three intrathecal injections of Wharton’s jelly-derived mesenchymal stem cells every two months at a dose of 30 × 106 cells. Patients were assessed using the ALSFRS-R scale. Survival times were followed-up until March 2020.

Results
Median survival time increased two-fold in all groups. In terms of progression, three response types measured in ALSFRS-R were observed: decreased progression rate (n = 21, 31.3%), no change in progression rate (n = 33, 49.3%) and increased progression rate (n = 13, 19.4%). Risk-benefit ratios were favorable in all groups. No serious adverse drug reactions were observed.

Interpretation
Wharton’s jelly-derived mesenchymal stem cells therapy is safe and effective in some ALS patients, regardless of the clinical features and demographic factors excluding sex. The female sex and a good therapeutic response to the first administration are significant predictors of efficacy following further administrations.
Wind Erosion Climate Change in Northern China During 1981–2016
Authors: Zhang Feng , Wang Jing’ai , Zou Xueyong , Mao Rui , Gong Daoyi , Feng Xingya 
Published: July 2020

AbstractWind erosion is largely controlled by climate conditions. In this study, we examined the influences of changes in wind speed, soil wetness, snow cover, and vegetation cover related to climate change on wind erosion in northern China during 1981–2016. We used the wind erosion force, defined as wind factor in the Revised Wind Erosion Equation Model, to describe the effect of wind speed on wind erosion. The results show that wind erosion force presented a long-term decreasing trend in the southern Northwest, northern Northwest, and eastern northern China during 1981–2016. In the Gobi Desert, the wind erosion force presented for 1981–1992 a decreasing trend, for 1992–2012 an increasing trend, and thereafter a weakly decreasing trend. In comparison to wind speed, soil wetness and snow cover had weaker influences on wind erosion in northern China, while vegetation cover played a significant role in the decrease of wind erosion in the eastern northern China during 1982–2015.