bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is Emergence Time Related to Emergence Agitation in Pediatric Patients?
Authors: pattaravit ngamjit , Karnjanawanichku Orarat , Siripruekpong Sirikarn , Kovitwanawong Nalinee , Reungchira-Urai Rongrong , Leeratiwong Jaranya 
Published: June 2020

Abstract
Background: Emergence agitation is one of the unpleasant symptoms after general anesthesia, especially in pediatric patients. This study was designed to evaluate the correlation between emergence time and emergence agitation. The predictors associated with emergence agitation and behavioral changes in children was also determined as specific outcomes.Methods: This prospective cohort study was conducted in children undergoing anesthesia between 3 to 12 years. The preoperative unit nurse evaluated the child's baseline behaviors preoperatively. From pre to post anesthesia period, nurse anesthetist recorded anesthetic management data and clinical emergence time. Meanwhile, the investigator team recorded the Processed-EEG emergence time. At the Post-Anesthetic Care Unit (PACU), the well trained PACU nurse evaluated clinical emergence time and emergence symptoms. For the behavioral symptoms, the investigator team evaluated any changes by telephone interview at postoperative days 1, 3, and 7. Statistical significance was set at p <0.05. Results: Ninety-one pediatric patients were enrolled in the study. Preoperative baseline behaviors were not related to emergence agitation or behavioral changes. There were correlations between clinical emergence time and the incidences of emergence agitation and postoperative separation anxiety. There was no relationship found between processed-EEG emergence time and the incidence of emergence agitation. Multivariate logistic regression analysis showed the significant predictors (ASA physical status, clinical emergence time, and pain) to predict Emergence agitation. (AUC=0.92, sensitivity = 0.89, specificity 0.81). Separation anxiety was significantly higher at postoperative days 1,3 and 7 in the children with emergence agitation (p-values = 0.020, 0.020, and 0.017, respectively).Conclusion: Clinical emergence time significantly related to emergence agitation and postoperative separation anxiety.Trial registration: ClinicalTrials.gov Identifier: NCT03358069. Registered 18 January 2017 - Retrospectively registered, https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S0007IOW&selectaction=Edit&uid=U0001FGB&ts=2&cx=-7ofx36
Introduction and geographic disparity of consultation-liaison psychiatry in Japan: Retrospective analysis of data from the Japanese National Inpatient database.
Authors: Shinjo Daisuke , Tachimori Hisateru , Maruyama-Sakurai Keiko , Fujimori Kenji , Inoue Norihiko , Fushimi Kiyohide 
Published: June 2020

Abstract
Background: Consultation-liaison psychiatry (CLP)—professional psychiatric care provided to coordinate with surgical or medical treatment of inpatients with psychiatric disorders—was included in universal health coverage in Japan in 2012. Despite evidence of benefits of CLP, basic data and geographic distribution information regarding CLP at the national level remain unclear. This study aimed to identify the clinical features and geographic disparity of CLP provided in Japan.Methods: We retrospectively analyzed anonymized data retrieved from the Japanese administrative inpatient database regarding inpatients who were provided CLP between April 2012 and March 2017. Demographic characteristics were summarized and geographic disparity by prefecture was visualized for fiscal years 2012 and 2016; we also summarized the data with descriptive statistics according to region. Results: Data from a total of 46,171 patients who received 138,866 CLP services were included. Results revealed more patients aged 75–84 years received CLPs than any other age group (29.7%) and the overall male/female ratio was 53:47 in 2016. In 2012 and 2016, 24.2% and 30.7% of CLP patients, respectively, were transferred to other hospitals; 9.7% and 8.8%, respectively, discharged due to the death. CLP services were provided in 14 prefectures in 2012 and 33 by 2016; 14 prefectures had no available CLP services.Conclusions: Our study clarified the characteristics of patients in Japan who received CLPs and the geographic disparity in CLP services. Although five years had passed since CLP was introduced, the results imply wide availability of CLP nationally. The analysis data provided may inform future policies to improve CLP services.
Circular Ribonucleic Acid Expression Profiles Differ Between the Plasma of Participants&nbsp;with Latent Autoimmune Diabetes in Adults and Healthy Individuals
Authors: Ning Lili , Yan Yan , Fu Xiying , Cheng Yan , Li Mo , Zhang Xiujuan , Shen Hong , Yang Maoguang , Wang Lijuan , Cai Hanqing 
Published: June 2020

Abstract
Background: To investigate the characteristic expression of circular RNAs (circRNA) in the peripheral blood of individuals with latent autoimmune diabetes in adults (LADA) and healthy individuals(NG) to identify dysregulated circRNAs that could be used to differentiate between LADA and healthy individuals. Results: A total of 992 differentially expressed circRNAs were detected in the Group LA vs Group NG:209 circRNAs were significantly upregulated and 783 circRNAs downregulated.These circRNAs distributed on all chromosomes, including the sex chromosomes, and most of the differentially expressed circRNAs were derived from exons. Two circRNAs were identified as the most distinctive differentially expressed targets, hsa_circ_0097425 and newly-discovered circRNA-hsa_circ_62540520. We used qRT-PCR to verify the differentially expressed circRNAs, both circRNAs were statistically significant (p <0.05). Further studies have found that the two circRNAs may be associated with metabolic syndrome , inflammation and cell cycle.Conclusion: We determined that differentially expressed circRNAs could be used as new biomarkers for distinguishing LADA from healthy individuals. Further investigations may illustrate the partial pathogenesis of diabetes mellitus.Trial registration: ChiCTR, ChiCTR1900020644. Registered 11 January 2019, http://www.chictr.org.cn/showproj.aspx?proj=30591
Clinicopathological Characteristics of Chinese Patients with Multiple Myeloma with Pleural Effusion: A Large Cohort Study
Authors: Li Qiu-yu , Zhang Tao , Zhang Zhen-hao , Ding Yan-ling , Zhu Hong 
Published: June 2020

Abstract
Background: Multiple myeloma (MM) is a hematologic malignancy of plasma cell origin. Multiple myeloma with pleural effusion (PE) is not uncommon. The existing literature on MM with PE in China and abroad is limited to case reports. Thus, it is necessary to investigate the characteristics of MM with PE and the associated prognosis to achieve early recognition and treatment.Method: Patients diagnosed with MM from January 2000 to December 2019 at Peking University Third Hospitals were assessed retrospectively. We summarized and analyzed the clinical manifestations, laboratory examinations, diagnosis and prognoses of patients by using clinical data and a literature review.Result: A total of 490 patients with MM were included. 272 patients (55.5%) had PE. Confirmed by pathology, there were 45 myelomatous pleural effusion (MPE) patients and 28 non-MPE patients. The total protein, albumin, calcium and complement C3 levels were lower and the β2-MG levels were higher in the PE group than in the non-PE group (P <0.05). Low total protein and low albumin levels were independent risk factors for PE. The levels of nucleated cells, total protein, LDH, and ADA were higher in the MPE group than the non-MPE group (P <0.05). There were no significant differences in the specific gravity or the levels of protein, glucose and CEA. Multivariate regression analysis suggested that low LDH levels and high levels of nucleated cell counts, total protein and ADA in PE were independent risk factors for MPE.Conclusions: PE is a complication of MM, and it is likely to be malignant. Low serum total protein and albumin levels are independent risk factors for MM with PE. Hypocomplement C3emia (activation of the complement bypass pathway) may affect the formation of PE in patients with MM. High nucleated cell counts, total protein and ADA levels as well as low LDH levels in PE were independent risk factors for MPE.
Dexamethasone promotes IL-4-induced alternative activation at PPARγ point, instead of upstream STAT6 in BV2 microglial cells
Authors: Chen Zongfeng , Zhang Liang , Xue Xin , Liu Peng , Yin Xiang , Xiang Yu , Liu Mingyong , Zhao Jianhua 
Published: June 2020

Abstract
Background

Microglia are innate immune effector cells in the central nervous system and play an extremely important role in the physiological processes of the central nervous system. When microglia are activated, there are two polarization states, M1 and M2 phenotype. Dexamethasone is a glucocorticoid widely used in clinical practice, which pharmacological effects are mainly anti-inflammatory, anti-toxic. However, whether Dexamethasone affects polarization state of microglia is unknown. In this study, we investigate the effect of Dexamethasone on IL-4-induced alternative activation in murine BV-2 microglial cells.
Methods

BV-2 cells were incubated with Dexamethasone alone, IL-4 alone, or the combination of Dexamethasone and IL-4. Western blot and immunofluorescence were performed to detect protein levels of alternative activation markers arginase 1 (Arg1), found in inflammatory zone 1 (FIZZ1). Moreover, we investigated the effects of Dexamethasone on IL-4 induced activation of signal transducer and activators of transcription 6 (STAT6) and peroxisome proliferator-activated receptor-gamma (PPARγ).
Results

Dexamethasone promoted IL-4 induced microglia alternative activation by increasing the expression of Arg1 and FIZZ1. Dexamethasone also enhanced the expression of PPARγ. These effects were reversed by RU486 (a Dexamethasone antagonist). Further, the effects of Dexamethasone and IL-4 on Arg1 and FIZZ1 were blocked by the application of GW9662 (a PPARγ antagonist).
Conclusions

Our studies confirm that Dexamethasone promotes IL-4 induced alternative activation via STAT6/PPARγ signaling pathways in microglia. At the same time, it was confirmed that Dexamethasone acts on PPARγ instead of STAT6. These findings support that Dexamethasone has a therapeutic potential for neuroinflammatory diseases via alternative activation.
Quantile regression forests to identify determinants of stroke: implications for neighborhoods with high prevalence
Authors: Hu Liangyuan , Ji Jiayi , Li Yan , Liu Bian 
Published: June 2020

Abstract
Background : Stroke exerts a massive burden on the U.S. health and economy. Place-based evidence is increasingly recognized as a critical part of stroke management but identifying the key determinants of stroke and the underlying effect mechanisms at the neighborhood level is a topic that has been treated sparingly in the literature. We aim to fill in the research gaps. We develop and apply analytical approaches to address two challenges. First, domain expertise on drivers of neighborhood-level stroke outcomes is limited. Second, commonly used linear regression methods may provide incomplete and biased conclusions.Methods: We created a new neighborhood health data set at census tract level by pooling information from multiple sources. We developed and applied a machine learning based quantile regression method to uncover crucial neighborhood characteristics for neighborhood stroke outcomes among vulnerable neighborhoods burdened with high prevalence of stroke. Results: Neighborhoods with a larger share of non-Hispanic blacks, older adults or people with insufficient sleep tended to have a higher prevalence of stroke, whereas neighborhoods with a higher socio-economic status in terms of income and education had a lower prevalence of stroke. The effects of five major determinants varied geographically and were significantly stronger among neighborhoods with high prevalence of stroke. Conclusions: Highly flexible machine learning identifies true drivers of neighborhood cardiovascular health outcomes from wide-ranging information in an agnostic and reproducible way. The identified major determinants and the effect mechanisms can provide important avenues for prioritizing and allocating resources to develop optimal community-level interventions for stroke prevention.
Transcriptome analysis in the shell gland of laying hens affecting eggshell qualities
Authors: Yang Xinyue , Zhao Fuping , Han Qiqi , Dong Yuanyang , Lei Jiaqi , Yang Chen , Guo Yuming , Ito Koichi , Zhang Bingkun 
Published: June 2020

Abstract
Background

Eggshell plays an important role in protecting against physical damage and microorganic invasion. It is subject to quality loss with increasing hen age, and fragile eggshells result in huge economic losses to the poultry industry. Therefore, improving eggshell quality is particularly important. However, little is known about the potential molecular mechanisms regulating eggshell quality in chickens.
Methods

In this study, we aimed to compare differential expression of long non-coding RNAs (lncRNAs) and mRNAs between old and young laying hens to identify related candidate genes for chicken shell gland development by the method of high-throughput RNA sequencing (RNA-seq).
Results

In total, we detected 176 and 383 differentially expressed (DE) lncRNAs and mRNAs, respectively. Moreover, functional annotation analysis based on the Gene Ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) databases revealed that DE-lncRNAs and DE-mRNAs were significantly enriched in “phosphate-containing compound metabolic process”, “mitochondrial proton-transporting ATP synthase complex”, “inorganic anion transport”, and other terms related to eggshell calcification and cuticularization. Through integrated analysis, we found that some important genes such as FGF14, COL25A1, GPX8, and GRXCR1 and their corresponding lncRNAs were expressed differentially between two groups, and the results of quantitative real-time polymerase chain reaction (qPCR) among these genes were also in excellent agreement with the sequencing data. In addition, our research indicates that FGF14, COL25A1, GPX8, and the members of the SLC family may be key genes that affect eggshell quality in hens.
Conclusions

This study provides a catalog of lncRNAs and mRNAs of the laying hen eggshell gland and will contribute to a fuller understanding of the molecular mechanisms of the function of the shell gland in poultry. Our findings will provide a valuable reference for the development of breeding programs aimed at breeding excellent poultry with high eggshell quality or regulating dietary nutrient levels to improve eggshell quality.
The optical coherence tomography angiography manifestation of strabismus amblyopia with eccentric fixation
Authors: Ren Hongxing , Cheng Jing , Qin Aijiao , Shi Minghua 
Published: June 2020

Abstract
BackgroundTo explore the application value of optical coherence tomography angiography (OCTA) in patients with strabismus amblyopia accompanied by eccentric fixation.MethodsThe following data were collected from patients with strabismus amblyopia accompanied by eccentric fixation: best corrected visual acuity (BCVA); spherical equivalent (SE) and deviation angle; eccentric fixation distance using OCTA system software tools, with µm as the unit of measurement of the distance between the retinal fixed point and the macular fovea; macular fovea vessel length density (VLD); perfusion density (PD); foveal avascular zone (FAZ) area; and perimeter and circularity of the superficial retinal vascular plexus. The entry criteria were as follows: OCTA scanning quality and signal strength of 8 or above (range 0 to 10).ResultsData from a total of 34 patients were collected: 17 patients with strabismus amblyopia with eccentric fixation were included in the experimental group, and 17 patients without strabismus with central fixation were included in the control group. The average deviation angle of the experimental group was 26.71 ± 25.88 prism dioptres (PD), the amblyopic eye BCVA was 0.24 ± 0.22, the SE was 4.35 ± 2.98 D, the stereoscopic median was 800", the eccentric fixation distance was 632.18 ± 310.62 µm, the macular fovea retinal thickness was 207.82 ± 17.79 µm, the VLD of the superficial retinal vascular plexus was 7.31 ± 3.84 mm− 1, the PD was 0.16 ± 0.08, the FAZ area was 0.28 ± 0.17 mm2, the FAZ perimeter was 2.05 ± 0.56 mm, and the FAZ circularity was 0.67 ± 0.06. These results showed statistically significant differences in the SE and BCVA compared with the lateral eye and the control group, but there were no statistically significant differences in the macular fovea retinal thickness, VLD, PD, or FAZ. The eccentric fixation of amblyopic eyes was directly related to the deviation angle, and the regression formula was as follows: the eccentric fixation distance of amblyopic eyes = 8.319 × the deviation angle + 410.002 (F = 13.878, P = 0.002 < 0.01).ConclusionThe eccentric fixation distance of strabismus amblyopia with eccentric fixation is related to the deviation angle; the greater the deviation angle is, the greater the distance of eccentric fixation.Trial registrationChinese Clinical Trial Registry, ChiCTR1900022830. Registered 27 April 2019, http://www.chictr.org.cn/
Use Of Psychoactive Substances And Sociodemographics Characteristics In A Hospitalized Population With Mental Disorders In A Mid-Income Country
Authors: CARMONA-HUERTA JAIME , Obeso Santiago Castiello-de , Aguirre-Ramírez Andrea , Pérez-Muñoz Sara , Cardona-Müller David , Grover-Páez Fernando , Iñiguez-Carvajal Bertha , Aldana-López Jesus Alejandro , Itzaman-Jiménez Israel , Medina-Dávalos Rafael 
Published: June 2020

Abstract
Introduction:

The use of psychoactive substances in patients diagnosed with mental illness is an increasing public health problem; the purpose of this work was to carry out a study to identify the most prevalent psychoactive drug abuse patterns in hospitalized patients in a psychiatric hospital, to estimate the severity of substance abuse, as well as to determine the factors associated with drug consumption using multivariate statistical modeling.
Methods

An analytical, retrospective study was carried out through the review of patient records discharged during 2018. Sociodemographic data, diagnoses, clinical follow-up information, clinimetric score of the alcohol consumption, Tobacco and Substances Detection Test (ASSIST 2.0) were obtained as well as the toxicological profile results.
Results

A representative sample of 268 participants was obtained, 61.6% men and 38.4% women, 86.6% unemployed, 67.9% single, with an average age of 36 years and 8 years of schooling. The most frequent diagnoses were Schizophrenia (42%), Substance-Induced Psychotic Disorder (22%), and Bipolar Disorder (17.9%). The most frequent substances detected in urine toxicology test were: Cannabis 21.8% (n = 45) and methamphetamines 10.7% (n = 22). The substances with the most frequent consumption in the last 3 months were tobacco, ethanol, cannabis, and methamphetamines. The highest score in the severity of consumption were methamphetamines and cannabis. The most important predictors for ethanol consumption were tobacco and cannabis abuse, for cannabis abuse were schooling years and ethanol consumption, and for methamphetamine consumption, the most important predictors were cocaine and cannabis abuse.
Conclusions

Young, male, unemployed subjects, with lower educational level, a psychiatric condition, and psychoactive consumption represent an identifiable "sociodemographic phenotype" that has an increased risk of requiring hospital services on a more recurrent basis and that could represent a burden to the health system. Methamphetamines abuse continues to increase and is becoming a significant mental health and public health issue. Cannabis and methamphetamine use are more severe and have more serious repercussions in terms of psychiatric morbidity. Correct public policies must be designed to intervene in this population.
A Study of Relationship Between Maternal Vitamin D Status&nbsp;and Mode of Delivery in a Tertiary Care Military Hospital
Authors: Dhillon Gurpreet Kaur , Singh Suneeta , Dhillon Harpreet Singh , Sasidharan Shibu 
Published: June 2020

Abstract
Background: Vitamin D deficiency has been shown to be related to multiple adverse pregnancy related outcomes. An observational study was undertaken to study the relationship between maternal serum vitamin D levels during peripartum period and outcome in the form of mode of delivery.Methods: This study was done in a tertiary care centre on 569 patients to study the relationship between maternal serum vitamin D levels and mode of delivery categorized into vaginal delivery (VD), (including assisted delivery) and Lower Segment Cesarean Section (LSCS). The primary objective of this project was to assess the vitamin D levels in maternal serum and to study its relationship, if any, with mode of delivery. Results: A total of 569 samples of maternal and neonatal serum were analyzed for serum 25(OH)D levels. 464 (81.54%) mothers had Vitamin D sufficient (VDS) levels ≥30ng/ml and 105 (18.45%) had vitamin D deficient (VDD) levels <30ng/ml. Out of total 569 newborns; LSCS and spontaneous Vaginal Delivery were 152 (26.71%) and 417 (73.28%) respectively. The incidence of LSCS was 19.61% in the vitamin D sufficient group as compared to 58.09% in the vitamin D deficient group (p<0.0005). The mean cord blood 25(OH) D levels of the neonates born by vaginal delivery was 14.05ng/ml (SD 3.86, range 8.2-27) whereas those born by LSCS was 12.11 ng/ml (SD 3.18, range 7.9-22), which was significantly lower (p<0.00000042).Conclusion: The rates of Cesarean section deliveries was 2.96 times higher in mothers who had deficient Vitamin D levels. Also the levels of mean cord blood vitamin D was higher in vaginally delivered newborns.
The Impact of Involvement of Father's with Preterm Newborns on their Paternal-Infant Bonding and Self-Efficacy: non-randomized clinical trial
Authors: Mirlashari Jila , Holsti Liisa , Ranjbar Hadi , Sanjari Mahnaz , Morovati Fatemeh , Ameri Zahra Daneshvar 
Published: June 2020

Abstract
Background: Premature birth and postpartum hospitalization can hurt the father-newborn bonding and fathers’ self-efficacy in the care of the newborn. This study was conducted to investigate the effect of the involvement of fathers with premature newborns on paternal-infant bonding and self-efficacy based on developmental care principles.Methods: This was a non-randomized clinical trial. Eighty fathers of hospitalized newborns in the neonatal intensive care unit were selected by convenience sampling method and divided into two groups ( 1 ). The intervention comprised training developmental care to fathers through simulations and then at the bedside of the newborn and the active involvement of fathers in the care of premature newborns admitted to the NICU. Pre-and post-intervention outcomes (after four weeks) were collected using Mother to Infant Bonding Scale and Perceived Maternal Parenting Self-Efficacy tool. Differences between groups were analyzed using independent t-test, paired t-test, repeated measures ANOVA.Results: The mean bonding score reduced by 2.3 ± 2.17 in the control group and 5.27 ± 2. 57 in the intervention group. A lower score represents a better bonding (f (1.78) = 9.19, p = 0.003). The self-efficacy score increased in both groups however, it was significantly higher in intervention group. In the intervention group increased by 8.85 ± 5.046, and in the control group, it increased by 1.27± 3.31, (f (1.78) = 21.88, p <0.001).Conclusions: Developmental care by fathers training and involvement in care can improve the father -infant bonding and increase the paternal self-efficacy for the care of the high risk newborn.Trial registration: Iranian Registry of Clinical Trials: IRCT20171010036690N1, 2018-01-31.