bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of CMTM8 polymorphisms on Lung Cancer Susceptibility in the Chinese Han Population
Authors: Wu Jiamin , Sun Yao , Xiong Zichao , Niu Fanglin , Liu Yuanwei , Li Haiyue , Liu Jianfeng , Liu Qiufang , Jin Tianbo 
Published: June 2020

Abstract
Objective: Lung cancer is the leading cause of cancer-related mortality worldwide and CMTM8 is a potential tumor suppressor gene, which is down-regulated in lung cancer. The objective of this research was to assess the association of CMTM8 genetic polymorphisms with lung cancer risk in Chinese Han population.Methods: To evaluate the correlation between CMTM8 polymorphisms and lung cancer risk, Agena MassArray platform was used for genotype determination among 509 lung cancer patients and 506 controls. Multiple genetic models, stratification analysis and haploview analysis was used by calculating odds ratio (OR) and 95% confidence intervals (CIs).Results: Significant associations were detected between CMTM8 rs6771238 and an increased lung cancer risk in codominant (adjusted OR = 1.57, 95%CI: 1.01-2.42, p = 0.044) and dominant (adjusted OR = 1.54, 95%CI: 1.01-2.36, p = 0.047)models. After gender stratification analysis,weobserved that rs6771238 was related to an increased risk of lung squamous cell carcinoma, while rs6771238 was associated with anincreased risk of lung adenocarcinoma. Rs9835916 and rs1077868 were correlated with lung cancer staging.Rs9835916 was linked to increased risk of lymph node metastasis in lung cancer patients. Conclusions: Our study firstly reported that the CMTM8 polymorphisms were a risk factors for lung cancer, which suggested the potential roles of CMTM8 in the development of lung cancerin Chinese Han population.
Visual Analytics for Network Events Classification in LAN With Deep Convolutional Neural Network
Authors: Sun Yuwei , Ochiai Hideya , Esaki Hiroshi 
Published: June 2020

Abstract
This article illustrates a method of visualizing network traffic in LAN based on the Hilbert Curve structure and the array exchange and projection, with nine types of protocols’ communication frequency information as the discriminators, the results of which we call them feature maps of network events. Several known scan cases are simulated in LANs and network traffic is collected for generating feature maps under each case. In order to solve this multi-label classification task, we adopt and train a deep convolutional neural network (DCNN), in two different network environments with feature maps as the input data, and different scan cases as the labels. We separate datasets with a ratio of 4:1 into the training dataset and the validation dataset. Then, based on the micro scores and the macro scores of the validation, we evaluate performance of the scheme, achieving macro-F-measure scores of 0.982 and 0.975, and micro-F-measure scores of 0.976 and 0.965 separately in these two LANs.
Protocol for Personal RF-EMF Exposure Measurement Studies in 5th Generation Telecommunication Networks
Authors: Velghe Maarten , Aerts Sam , Martens Luc , Joseph Wout , Thielens Arno 
Published: June 2020

Abstract
Background

The general population is exposed to Radio-Frequency Electromagnetic Fields (RF-EMFs) used by telecommunication networks. Previous studies developed methods to assess this exposure. These methods will be inadequate to accurately assess exposure in 5G technologies. This is due to the fact that 5G NR (new radio) base stations will focus actively on connected users, resulting in a high spatio-temporal variations in the RF-EMFs. This increases the measurement uncertainty in personal measurements of RF-EMF exposure. Furthermore, a user’s exposure from base stations will be dependent on the amount of data usage, adding a new component to the auto-induced exposure, which is often omitted in current studies.

Methods

The objective of this paper is to develop a general study protocol for future personal RF-EMF exposure research adapted to 5G technologies. This protocol will include the assessment of auto-induced exposure of both a user’s own devices and the networks’ base stations.

Results

To account for auto-induced exposure, an activity-based approach is introduced. In survey studies, an RF-EMF sensor is fixed on the participants’ mobile device(s). Based on the measured power density, GPS data and movement and proximity sensors, different activities can be clustered and the exposure during each activity is evaluated. In microenvironmental measurements, a trained researcher performs measurements in predefined microenvironments with a mobile device equipped with the RF-EMF sensor. The mobile device is programmed to repeat a sequence of data transmission scenarios (different amounts of uplink and downlink data transmissions). Based on simulations, the amount of exposure induced in the body when the user device is at a certain location relative to the body, can be evaluated.

Conclusion

Our protocol addresses the main challenges to personal exposure measurement introduced by 5G NR. A systematic method to evaluate a user’s auto-induced exposure is introduced.
The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolism
Authors: BLASCO H. , BESSY C. , PLANTIER L. , LEFEVRE A. , PIVER E. , BERNARD L. , MARLET J. , STEFIC K. , DE BRETAGNE I. BENZ , CANNET P. , LUMBU H. , MOREL T. , BOULARD P. , ANDRES C.R. , VOURCH P. , HERAULT O. , GUILLON A. , EMOND P. 
Published: June 2020

Abstract
BackgroundThe biological mechanisms involved in SARS-CoV-2 infection are only partially understood. Thus we explored the plasma metabolome of patients infected with SARS-CoV-2 to search for diagnostic and/or prognostic biomarkers and to improve the knowledge of metabolic disturbance in this infection.Materials and Methods We analyzed the plasma metabolome of 55 patients infected with SARS-CoV-2 and 45 controls by LC-HRMS at the time of diagnosis (D0). We first evaluated the ability to predict the diagnosis from the metabotype at D0 in an independent population. Next, we assessed the feasibility of predicting the disease evolution at the 7th and 15th day.ResultsPlasma metabolome allowed us to generate a discriminant multivariate model to predict the diagnosis of SARS-CoV-2 in an independent population (accuracy>74%, sensitivity, specificity>75%). We identified the role of the cytosine and tryptophan-nicotinamide pathways in this discrimination. However, metabolomic exploration modestly explained the disease evolution.DiscussionHere, we present the first metabolomic study in SARS-CoV-2 patients which showed a high reliable prediction of early diagnosis. We have highlighted the role of the tryptophan-nicotinamide pathway clearly linked to inflammatory signals and microbiota, and the involvement of cytosine, previously described as a coordinator of cell metabolism in SARS-CoV-2. These findings could open new therapeutic perspectives as indirect targets.
Mathematical Analysis of the Role of Detection Rate on Dynamical Spread of Ebola Virus Disease
Authors: Olajide Akanni John 
Published: June 2020

In this paper, a non-linear mathematical model of the Ebola virus disease with detection rate is proposed and analyzed. The whole population under consideration is divided into five compartments e.g. susceptible, latently infected, infected undetected, infected detected, and recovered to study the transmission dynamics of the Ebola virus disease. Based on the immunity level, susceptible individuals move to exposed class or directly to infected detected class once they come into contact with an infective. This has been incorporated through the progression rate which is slow. The equilibria of the model and the basic reproduction number R0 are computed. It is observed that the disease-free equilibrium of the model is locally asymptotically stable when R0<1. The model exhibits forward bifurcation under certain restrictions on parameters, which indicate that the model has a single endemic equilibrium for R0<1. This suggests that an accurate estimation of parameters and the level of control measures are required to reduce the infection prevalence of the Ebola virus in the endemic region and just R0<1 is enough to eliminate the disease from the population. R0 needs to be lowered much below one to confirm the global stability of the disease-free equilibrium. Numerical simulation is performed to demonstrate the analytical results. It is found that the increase in the rate of detection rate leads to a decrease in the threshold value of R0. Numerical simulations have been carried out to support the analytic results.
ANALISIS KEMAMPUAN PEMAHAMAN KONSEP MATEMATIS PESERTA DIDIK PADA MATERI TRIGONOMETRI BERDASARKAN GAYA BELAJAR
Authors: Setiana Dewi 
Published: June 2020

Tujuan dari penelitian ini adalah untuk menganalisis kemampuan pemahaman konsep peserta didik dalam pemecahan masalah ditinjau dari gaya belajar. Analisis pemahaman konsep dalam penelitian ini menggunakan kriteria dari Peraturan Dirjen Dikdasmen Depdiknas dengan Nomor 576/C/TU/2006. Penelitian ini merupakan jenis penelitian kualitatif dalam bentuk deskriptif. Subjek penelitian adalah peserta didik kelas X TMPO-2 SMK Negeri 3 Semarang yang berjumlah 36 anak. Penelitian ini menunjukkan bahwa perbedaan gaya belajar tidak secara signifikan mempengaruhi kemampuan pemahaman konsep peserta didik. Penelitian ini memberikan informasi bahwa gaya belajar visual, auditori, dan kinestetik dalam hal keterampilan memahami konsep hanya terdapat sedikit perbedaan dalam prosesnya. Hal ini dikarenakan subjek visual dan kinestetik sama-sama mampu menguasai 6 dari 7 indikator pemahaman konsep, sedangkan untuk subjek auditori mampu memahami keseluruhan indikator pemahaman konsep dalam penelitian ini. Hasil analisis disimpulkan bahwa subjek auditori memiliki kemampuan yang lebih tinggi di banding dengan subjek visual dan kinestetik.
The Proportion of Type 2 Diabetic Patients Achieving Treatment Goals and the Survey of Patients’ Attitude Towards Insulin In tiation ini Patient s with Inadequate Glycaemic Control with Oral Anti-diabetic Drugs
Authors: Bhat Shivashankara , Chowta Mukta , Chowta Nithyananda , Shastry Rajeshwari , Kamath Priyanka 
Published: June 2020

Background:
Type 2 diabetic patients often require insulin therapy for better glycaemic control.
However, many of these patients do not receive insulin or do not receive it in a timely manner.

Objective:
The study was planned to assess the proportion of type 2 diabetic patients attaining treatment
goals as per the ADA 2018 guidelines. In addition, patient’s perception of insulin therapy was assessed
and compared between insulin naïve and insulin-initiated type 2 diabetic patients.

Methods:
The study was conducted in type 2 diabetic patients. Data on their demographics, medical history,
duration of diabetes, history of diabetes related complications, the current anti-diabetic medication
received, and the most recent glycaemic parameters were all noted. Patient’s perception of insulin initiation
was recorded through a structured interview.

Results:
A total of 129 patients were included in the study. Around 76.7% patients achieved HbA1c target
(<7%). The duration of the disease is much higher in patients who did not meet the HBA1c target. A
good number of patients felt that insulin injection would be physically painful (56.5%). The majority of
the patients also felt that insulin would make their life less flexible (64.8%). Many patients have the opinion
that insulin is required for life long (73.2%). More number of patients on insulin agreed with the statement
‘Leads to good short-term outcomes as well as long-term benefits’ compared to insulin naïve patients.

Conclusion:
The results highlight that the proportion of patients achieving the recommended glycaemic
target is not satisfactory. Many patients who are inadequately controlled with oral anti-diabetic drugs
were reluctant to initiate insulin.
Spontaneous Biliary Pericardial Tamponade: A Case Report and Literature Review
Authors: Battisha Ayman , Altibi Ahmed M. , Madoukh Bader , Sheikh Omar , Sawalha Khalid , Shaikh Shakil , Al-Sadawi Mohammed 
Published: June 2020

Background:
Biliary pericardial tamponade (BPT) is a rare form of pericardial tamponade,
characterized by yellowish-greenish pericardial fluid upon pericardiocentesis. Historically,
BPT reported to occur in the setting of an associated pericardiobiliary fistula. However, BPT in the
absence of a detectable fistula is extremely rare.

Learning objective::
A biliary pericardial tamponade is a rare form of tamponade warranting a
prompt workup (e.g., MRCP or HIDA scan) for a potential fistula between the biliary system and
the pericardial space. A pericardio-biliary fistula can be iatrogenic or traumatic. People with a history
of chest wall trauma, abdominal surgery, or chest surgery are at increased risk. The use of
HIDA scanning plays a salient role in effectively surveilling for the presence of a fistula – especially
when MRCP is contraindicated.

Case Presentation:
A 75-year-old Hispanic male presenting with dyspnea and diagnosed with cardiac
tamponade is the subject of the study. Subsequent pericardiocentesis revealed biliary pericardial
fluid (bilirubin of 7.6 mg/dl). The patient underwent extensive workup to identify a potential
fistula between the hepatobiliary system and the pericardial space, which was non-revealing. The
mechanism of bile entry into the pericardial space remains to be unidentified.

Literature Review:
A total of six previously published BPT were identified: all were males, with a
mean age of 53.3 years (range: 31-73). Mortality was reported in two out of the six cases. The underlying
etiology for pericardial tamponade varied across the cases: incidental pericardio-biliary
fistula, traumatic pericardial injury, and presence of associated malignancy.

Conclusion::
Biliary pericardial tamponade is a rare form of tamponade that warrants a prompt
workup (e.g., Hepatobiliary Iminodiacetic Acid – HIDA scan) for an iatrogenic vs. traumatic pericardio-
biliary fistula. As a first case in the literature, our case exhibits a biliary tamponade in the
absence of an identifiable fistula.
Meaningfulness of Work and Employee Engagement: The Role of Affective Commitment
Authors: Kaur Prabhjot , Mittal Amit 
Published: June 2020

Background:Meaningfulness of work leads to positive job-related consequences, such as engaged, satisfied, productive, trustworthy, and devoted employees.Purpose:The main purpose of this research was to study the relationship between meaningfulness of work, employee engagement, and affective commitment. Further, this study is also examined the mediating influence of affective commitment on the relationship between meaningfulness of work and employee engagement.Methods:Researchers used a quantitative approach to collect data for the research by utilizing a cross-sectional survey design. The study included standardized scales and was conducted on 319 employees working in the service sector of Punjab and Chandigarh, India.Results:The findings of the given study confirmed a positive relationship between meaningfulness of work, employee engagement, and affective commitment.Conclusion:Moreover, affective commitment acts as a mediator on the relationship between the meaningfulness of work and employee engagement.
Nuezhenide Exerts Anti-Inflammatory Activity through the NF-κB Pathway
Authors: Wang Qin-Qin , Han Shan , Li Xin-Xing , Yuan Renyikun , Zhuo Youqiong , Chen Xinxin , Zhang Chenwei , Chen Yangling , Gao Hongwei , Zhao Li-Chun , Yang Shilin 
Published: June 2020

Background:Nuezhenide (NZD), an iridoid glycoside isolated from Ilex pubescens Hook. & Arn. var. kwangsiensis Hand.-Mazz., used as a traditional Chinese medicine for clearing Hook. & Arn. var. kwangsiensis Hand.-Mazz., used as a traditional Chinese medicine for clearing away heat and toxic materials, displays a variety of biological activities such as anti-tumor, antioxidant, and other life-protecting activities. However, a few studies involving anti-inflammatory activity and the mechanism of NZD have also been reported. In the present study, the anti-inflammatory and antioxidative effects of NZD are illustrated.Objective:This study aims to test the hypothesis that NZD suppresses LPS-induced inflammation by targeting the NF-κB pathway in RAW264.7 cells.Methods:LPS-stimulated RAW264.7 cells were employed to detect the effect of NZD on the release of cytokines by ELISA. Protein expression levels of related molecular markers were quantitated by western blot analysis. The levels of ROS, NO, and Ca2+were detected by flow cytometry. The changes in mitochondrial reactive oxygen species (ROS) and mitochondrial membrane potential (MMP) were observed and verified by fluorescence microscopy. Using immunofluorescence assay, the translocation of NF-κB/p65 from the cytoplasm into the nucleus was determined by confocal microscopy.Results:NZD exhibited anti-inflammatory activity and reduced the release of inflammatory cytokines such as nitrite, TNF-α, and IL-6. NZD suppressed the expression of the phosphorylated proteins like IKKα/β, IκBα, and p65. Besides, the flow cytometry results indicated that NZD inhibited the levels of ROS, NO, and Ca2+in LPS-stimulated RAW264.7 cells. JC-1 assay data showed that NZD reversed LPS-induced MMP loss. Furthermore, NZD suppressed LPS-induced NF-B/p65 translocation from the cytoplasm into the nucleus.Conclusions:NZD exhibits anti-inflammatory effects through the NF-κB pathway on RAW264.7 cells.
Diode Array Detection for UPLC Determination of Cinnarizine and Dimenhydrinate in their Combined Dosage Form
Authors: Lamie Nesrine T. , Monir Hany H. 
Published: June 2020

Background:
Cinnarizine is used to treat nausea and vomiting accompanied by motion
sickness. Dimenhydrinate is used in the treatment of nausea and vomiting and dizziness. The
coformulation of the two drugs showed the lowest rate of adverse effects compared to single dimenhydrinate.

Objective:
A fully validated ultra-performance liquid chromatographic method has been conducted
for the simultaneous estimation of cinnarizine (CIN) and dimenhydrinate (DIM).

Materials and Methods:
The UPLC method used Acquity Column as stationary phase and mobile
phase methanol: buffer (pH = 3.5 ± 0.05) and acetonitrile in the ratio of 50: 25: 25 at a flow rate of
0.2 mL/min. Detection was performed by DAD at 260 nm.

Results and Discussion:
Retention time was 0.71 and 1.12 min for DIM and CIN, respectively.
The linearity was found to be 1-40 μg/mL and 2-80 μg/mL for CIN and DIM; respectively.

Conclusion:
The method was appropriately used for the quantitation of both drugs in pure form,
synthetic mixtures and tablet preparation.
Exploration of Mesyl Chloride in a One Pot Conversion of Carboxylic Acids to Ketones
Authors: Mekonnen Habtamu Gelaw , Sahoo Debasis , Jana Samaresh , Maji Sanjoy Kumar 
Published: June 2020

Background:
Due to the ubiquitous nature of the ketone functionality, it is considered an
important functional group in organic chemistry. Hence, the synthesis of ketones from readily available
starting materials is an important chemical transformation in organic synthesis. Consequently, several
research efforts have been reported in the literature for the transformation of carboxylic acids to ketones
in a one-pot synthesis. However, some of the procedures have limitations, such as long reaction
times, harsh reaction conditions, and usage of expensive metal catalysts. Thus, a simple and convenient
one-pot conversion of carboxylic acids to ketones remains desirable.

Objective:
We intended to develop a simple and convenient one-pot methodology for the synthesis of
ketones from carboxylic acids. Our objective was to build up a carboxylic acid-based chemical template
where various types of organometallic reagents can interact to produce the desired ketone.

Methods:
In this procedure, a carboxylic acid was converted to a mixed anhydride using mesyl chloride
in the presence of a base. This mixed anhydride was then reacted with a suitable organometallic reagent
at -20°C to obtain the desired ketone. The reaction was performed in a one-pot fashion.

Results:
Under the optimized reaction conditions, various aromatic and heteroaromatic carboxylic acids
were converted to the corresponding ketones using organolithium and organomagnesium reagents
with short reaction times. Moderate to good yields of the desired ketones were observed in many of
these transformations.

Conclusion:
A simple and convenient one-pot method for the conversion of carboxylic acids to ketones
has been reported. Specifically, various aromatic and `heteroaromatic carboxylic acids have been converted
to the corresponding ketones in moderate to good yields. Organomagnesium and organolithium reagents
were used as nucleophiles for this reaction.
HUBUNGAN MOTIVASI, ATTITUDE, ANXIETY DAN SELF EFFICACY TERHADAP PRESTASI ATLET TENIS LAPANGAN LEVEL JUNIOR DAN SENIOR
Authors: Alim Abdul 
Published: June 2020

Tujuan penelitian ini adalah untuk mengetahui hubungan motivasi, attitude, anxiety, dan self efficacy terhadap prestasi atlet tenis lapangan dan menganalisis perbedaan hubungan antara atlet tenis lapangan pada level junior dan senior. Metode penelitian untuk mengungkapkan masalah tersebuat yaitu melalui metode penelitian deskriptif dengan desain penelitian deskriptif komparatif korelasional. Populasi dalam penelitian ini adalah atlet tenis lapangan tingkat Daerah maupun Nasional di Indonesia. Sampel penelitian ini berjumlah 133 terdiri dari 42 petenis laki-laki junior dan 21 petenis perempuan junior, 44 petenis laki-laki senior, dan 26 petenis perempuan senior. Teknik sampling yang digunakan dalam penelitian ini adalah teknik insidental sampling yang dilakukan dengan cara insidental atau kebetulan saja tidak menggunakan perencanaan tertentu. Penelitian dilakukan pada minggu kedua bulan Februari sampai minggu keempat bulan Juni. Instrumen yang digunakan pada penelitian ini adalah kuesioner. Hasil analisis data dari 133 orang petenis baik junior maupun senior menunjukkan bahwa baik motivasi, self efficacy, attitude, maupun kecemasan tidak memiliki hubungan yang signifikan dengan prestasi. RELATIONSHIP MOTIVATION, ATTITUDE, ANXIETY AND EFFICIENCY OF SELF TO THE ACHIEVEMENT OF TENNIS FIELD JUNIOR AND SENIOR LEVELS AbstractThe purpose of this study was to determine the relationship of motivation, attitude, anxiety, and self-efficacy on the achievements of field tennis athletes and analyze the differences in the relationship between field tennis athletes at the junior and senior levels. The research method to express the problem is through descriptive research method with a comparative descriptive research design. The population in this study are regional and national level tennis athletes in Indonesia. The research sample consisted of 133 consisting of 42 junior male tennis players and 21 junior female tennis players, 44 senior male tennis players, and 26 senior female tennis players. The sampling technique used in this study is incidental sampling technique which is done by incidental or coincidental by not using a particular plan. The study was conducted in the second week of February through the fourth week of June. The instrument used in this study was a questionnaire. The results of data analysis of 133 tennis players, both junior and senior, indicate that neither motivation, self efficacy, attitude, or anxiety do not have a significant relationship with achievement.