bluuebunny/crossref_metadata_2025_split huggingface dataset:
HER-2, Hormone Receptors, and clinicopathologic characteristics in Uruguayan breast cancer patients
Authors: Delgado L. B. , Fresco R. , Santander G. , Aguiar S. , Camejo N. , Ferrero L. , González V. , Heinzen S. , Martinez A. , Sabini G. 
Published: August 2020

e22202 Background: Few Latin-American studies and none Uruguayan study have evaluated HER-2, estrogen receptor (ER) and progesterone receptor (PR) in breast cancer (BC). The purpose of the study was to investigate the frequency of these markers and the relationship between them and with clinicopathologic features in Uruguayan BC patients (pts). Methods: We retrospectively reviewed clinical records from pts who underwent curative surgery for stage I-III invasive BC at the Oncology Units of 4 institutions in Montevideo between march 2006 and march 2008. We obtained the following data: age, TNM, ER/PR status by immunohistochemistry (IHC) and HER2 status by IHC and FISH in HER2 IHC 2+. Fisher's exact test was used to analyze the data. Results: 427 pts were included. Median age was 60 years-old (range: 24–93 y), postmenopausal 75%, stages: I 33%, II 42%, III 23%, unknown 2%. ER/PR status was known in 94,6% of cases: ER+/PR+ 66,1%, ER+/PR- 11,1%, ER-/PR+ 3,5%, ER-/PR- 19,3%. HER2 status was known in 47% (199/427) of cases, being positive (IHC 3+ or FISH+) in 13.6%. Triple negative tumors were found in 32 of 199 pts (16%). HER2 was positive in 8% of pts with ER+ and/or PR+ tumors, and in 18% of pts with ER-PR- disease (p=0.08). We did not find a significant association between axillary lymph node status and HER2 status. Besides, triple negative BC did not correlate with axillary lymph node status. When analized by menopausal status, the frequency of triple negative pts was 14% in the premenopausal group and 4% in the postmenopausal group (p=0.005). In addition, the rate of triple negative BC was 0% in pts with histologic grade 1 and 10% in pts with histologic grade 2–3 (p = 0.0005). Conclusions: Our data from Uruguayan pts show a lower prevalence of HER2 positive but a similar prevalence of ER+ and PR+ operable BC than the prevalence reported in most American and European studies. In accordance with previous reports, triple negative BC correlated with younger age and higher histologic grade. No significant financial relationships to disclose.
A prospective, randomized trial of chemotherapy with or without the low molecular weight heparin (LMWH) enoxaparin in patients (pts) with advanced pancreatic cancer (APC): Results of the CONKO 004 trial
Authors: Riess H. , Pelzer U. , Deutschinoff G. , Opitz B. , Stauch M. , Reitzig P. , Hahnfeld S. , Hilbig A. , Stieler J. , Oettle H. 
Published: August 2020

LBA4506 The full, final text of this abstract will be available in Part II of the 2009 ASCO Annual Meeting Proceedings, distributed onsite at the Meeting on May 30, 2009, and as a supplement to the June 20, 2009, issue of the Journal of Clinical Oncology. No significant financial relationships to disclose.
Carboplatin plus paclitaxel versus carboplatin plus stealth liposomal doxorubicin in patients with advanced ovarian cancer (AOC): Final results of the MITO-2 randomized multicenter trial
Authors: Pignata S. , Scambia G. , Savarese A. , Sorio R. , Breda E. , Ferrandina G. , Gebbia V. , Musso P. , Gallo C. , Perrone F. 
Published: August 2020

LBA5508 The full, final text of this abstract will be available in Part II of the 2009 ASCO Annual Meeting Proceedings, distributed onsite at the Meeting on May 30, 2009, and as a supplement to the June 20, 2009, issue of the Journal of Clinical Oncology. No significant financial relationships to disclose.
Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes
Authors: Flinn Michael A. , Otten Cécile , Brandt Zachary J. , Bostrom Jonathan R. , Kenarsary Aria , Wan Tina C. , Auchampach John A. , Abdelilah-Seyfried Salim , O'Meara Caitlin C. , Link Brian A. 
Published: August 2020

ABSTRACT
The Hippo-Yap pathway regulates multiple cellular processes in response to mechanical and other stimuli. In Drosophila, the polarity protein Lethal (2) giant larvae [L(2)gl], negatively regulates Hippo-mediated transcriptional output. However, in vertebrates, little is known about its homolog Llgl1. Here, we define a novel role for vertebrate Llgl1 in regulating Yap stability in cardiomyocytes, which impacts heart development. In contrast to the role of Drosophila L(2)gl, Llgl1 depletion in cultured rat cardiomyocytes decreased Yap protein levels and blunted target gene transcription without affecting Yap transcript abundance. Llgl1 depletion in zebrafish resulted in larger and dysmorphic cardiomyocytes, pericardial effusion, impaired blood flow and aberrant valvulogenesis. Cardiomyocyte Yap protein levels were decreased in llgl1 morphants, whereas Notch, which is regulated by hemodynamic forces and participates in valvulogenesis, was more broadly activated. Consistent with the role of Llgl1 in regulating Yap stability, cardiomyocyte-specific overexpression of Yap in Llgl1-depleted embryos ameliorated pericardial effusion and restored blood flow velocity. Altogether, our data reveal that vertebrate Llgl1 is crucial for Yap stability in cardiomyocytes and its absence impairs cardiac development.
REal-time Assessment of Community Transmission (REACT) of SARS-CoV-2 virus: Study protocol
Authors: Riley Steven , Atchison Christina , Ashby Deborah , Donnelly Christl A. , Barclay Wendy , Cooke Graham S. , Ward Helen , Darzi Ara , Elliott Paul ,   REACT study group
Published: August 2020

Background: England, UK has one of the highest rates of confirmed COVID-19 mortality globally. Until recently, testing for the SARS-CoV-2 virus focused mainly on healthcare and care home settings. As such, there is far less understanding of community transmission. Protocol: The REal-time Assessment of Community Transmission (REACT) programme is a major programme of home testing for COVID-19 to track progress of the infection in the community. REACT-1 involves cross-sectional surveys of viral detection (virological swab for RT-PCR) tests in repeated samples of 100,000 to 150,000 randomly selected individuals across England. This examines how widely the virus has spread and how many people are currently infected. The age range is 5 years and above. Individuals are sampled from the England NHS patient list. REACT-2 is a series of five sub-studies towards establishing the seroprevalence of antibodies to SARS-CoV-2 in England as an indicator of historical infection. The main study (study 5) uses the same design and sampling approach as REACT-1 using a self-administered lateral flow immunoassay (LFIA) test for IgG antibodies in repeated samples of 100,000 to 200,000 adults aged 18 years and above. To inform study 5, studies 1-4 evaluate performance characteristics of SARS-CoV-2 LFIAs (study 1) and different aspects of feasibility, usability and application of LFIAs for home-based testing in different populations (studies 2-4). Ethics and dissemination: The study has ethical approval. Results are reported using STROBE guidelines and disseminated through reports to public health bodies, presentations at scientific meetings and open access publications. Conclusions: This study provides robust estimates of the prevalence of both virus (RT-PCR, REACT-1) and seroprevalence (antibody, REACT-2) in the general population in England. We also explore acceptability and usability of LFIAs for self-administered testing for SARS-CoV-2 antibody in a home-based setting, not done before at such scale in the general population.
KEADILAN TERHADAP DOKTER PADA KASUS PENGGUNAAN OBAT YANG BELUM TERDAFTAR DI BPOM REPUBLIK INDONESIA
Authors: Masputra M Hendra Cordova , Setiyono Joko , Irawati Irawati 
Published: August 2020

Penggunaan obat ataupun krim yang diberikan oleh dokter klinik kecantikan tidak lepas dari supervisi berasal Badan Pengawas Obat dan Makanan (BPOM). Tidak jarang Dokter ternyata tidak mengetahui bahwa obat yang diberikan belum tercatat pada BPOM. Penelitian ini bertujuan menganalisis Keadilan dalam pemberian pidana terhadap dokter terkait penggunaan obat yang belum terdaftar di BPOM. Metode Penelitian menggunakan metode yuridis normatif dengan bahan hukum sekunder. Hasil penelitian menunjukkan Putusan terhadap terdakwa dinyatakan bersalah karena menggunakan obat-obatan yang belum terdaftar di BPOM, karena ketidaktahuan terhadap obat digunakan belum terdaftar di BPOM. Kesimpulan penelitian ini adalah kasus dalam Putusan Nomor 2008 K/Pid.Sus/2016, secara legal memang bersalah, namun. Seharusnya hakim dapat mempertimbangkan tindakan untuk dapat memberikan keringanan terhadap Dr. Trifena terhadap ketidaktahuannya. Sebagai Aparat penegak hukum menjadi salah satu lembaga yang sangat penting dalam menegakkan hukum yang ada. Berjalannya suatu keadilan dan kepastian hukum di dalam pengadilan tergantung pada setiap keputusan dari hakim.
AKOMODASI PEMBERANTASAN TINDAK PIDANA PERDAGANGAN ORANG DALAM ASPEK HUKUM INTERNASIONAL DAN NASIONAL
Authors: Sitania Lourensy Varina , Suponyono Eko 
Published: August 2020

Human Trafficking atau perdagangan orang merupakan kejahatan yang menjadi sorotan dunia dan terorganisir, dengan adanya kemajuan teknologi informasi, komunikasi dan transportasi yang memberikan akses kepada kejahatan tersebut menjadi terstruktur dan sistematis. Tujuan penulisan ini adalah ini untuk melihat tindakan yang telah dilakukan negara Indonesia dalam memberantas tindak pidana perdagangan orang sejalan dengan pengakomodasian ketentuan protokol palermo tahun 2000. Dilihat pada bagaimana korban diberikan perlindungan dan mengetahui sanksi aturan hukum yang diratifikasikan ke dalam hukum nasional memiliki kekuatan hukum yang mengandung efek jerah terhadap pelaku kejahatan, dalam hal pelaksanaan penegakan hukum. Metode penelitian menggunakan pendekatan hukum normatif dengan pendekatan perundang-undangan dan pendekatan komparatif, dimana melihat ketentuan hukum dalam pencegahan permasalahan dan dari kaijan bahan hukum maupun artikel yang membahas tentang pemberantasan perdagangan manusia. Hasil dari penelitian ini adalah Human Trafficking telah menjadi kejahatan yang berkembang dimana dalam hal pencegahan tindak pidana yang menjadi kekuatan bagi negara untuk memerangi kejahatan tersebut.Hasil dari penelitian ini adalah Pengakomodasian Protokol Palermo dalam Peraturan Perundang-undangan Tindak Pidana Perdagangan Orang di Indonesia, yang dikeluarkan oleh bangsa-bangsa dan negara yang memerangi adanya perdagangan orang dalam memberikan sanksi terhadap pelaku dan memberikan perlindungan terhadap korban kejahatan dalam memberikan kesejahteraan bagi bangsa dan negara.
Solid Concentration Effect for Solvent Extraction Process of Oily Contaminated Soil
Authors: Fitriyani Lely , Karadena Edwan , Sukandar Sukandar 
Published: August 2020

Solvent extraction has been used as a method to wash oil content of oily contaminated soil in industry for years. Some solvents and temperature ranges has been chosen to increase the oil recovery rate of extraction process, however only few studies reported that it has been able to reach remaining Total Petroleum Hydrocarbon (TPH) less than 0.5% in less than 30 minutes. During the experiments, acetone and toluene chosen to extract oil content from contaminated soil by using solvent extraction process. Temperature selected were between 24°C up to 70°C. Mixing apparatus which has been utilized was centrifugation machine with 1000 rpm (1570 g) operational speed. Duration of treatment process was 10 minutes with some variations of solid to solvent ratio. During the experiments, it was observed that by using toluene and acetone as solvents, the optimum Total Petroleum Hydrocarbon (TPH) removal obtained at temperature 50°C. In the other hand, optimum solid to solvent ratio toluene ratio was 1:6. As a solvent acetone observed capable to reduce TPH content until below 0.5% as threshold limit for TPH of contaminated soil regulated by environmental regulation in Indonesia. During the experiments it was also observed the dependency of solid concentration (Cs) with dissociation coefficient (KD). In the other hand, heavy metal at the remaining extracted soil after soil washing was observed available in safe concentration to be discharged to the environment base on regulation in Indonesia. Keywords: solvent extraction, soil washing, contaminated soil, TPH, centrifugation, oil sludge, acetone, toluene, solid treatment.
The Genesis of General Relativity: Interaction between Einstein’s, Abraham’s and Nordström’s Research Programmes
Authors: Nugayev Rinat M. 
Published: August 2020

AbstractThe arguments are exhibited in favour of the necessity to modify the history of the genesis and advancement of general relativity (GR). I demonstrate that the dynamic creation of GR had been continually governed by internal tensions between two research traditions, that of special relativity and Newton’s gravity. The encounter of the traditions and their interpenetration entailed construction of the hybrid domain at first with an irregular set of theoretical models. Step by step, on eliminating the contradictions between the models contrived, the hybrid set was put into order. It is contended that the main reason of the GR victory over the rival programmes of Abraham and Nordström was a synthetic character of Einstein’s programme. Einstein had put forward as a basic synthetic principle the principle of equivalence that radically differed from that of rival approaches by its open, flexible and contra-ontological character.
Evaluating at Three Scales the Hydraulic Conductivity in an Unconfined and Stratified Alluvial Aquifer
Authors: Chapuis Robert P. 
Published: August 2020

Abstract
The values of hydraulic conductivity (K) were evaluated at three scales in a stratified alluvial aquifer. The small scale is that of hundreds of soil samples for which K was estimated using predictive methods. A first estimate assumed that each sample was homogeneous. A second estimate proceeded with the modal decomposition for the grain-size distribution curve: this quantified the existing and visually confirmed stratification before predicting K. The medium scale is that of hundreds of variable-head (slug) permeability tests in monitoring wells. The large scale is that of 16 pumping tests in steady-state conditions. The aquifer heterogeneity was quantified with the K values distribution curves for small and medium scales and their modal decompositions. The large data sets provided an excellent opportunity to check the lognormal assumption for the K distributions. Large-scale K values were predicted from the small-scale K distribution with assumed stratification and also from medium-scale K distribution: these predicted values were found to be equal to the mean K value of pumping tests. Therefore, if the grain-size distributions are correctly interpreted and the field permeability tests are correctly performed and interpreted, the distribution curves for the small-scale and medium-scale K values explain the large-scale K values of pumping tests, and there is no need to invoke any scale effect.
El concepto de cultura en los fundadores de la filosofía latinoamericana
Authors: Nakajima Bernardo 
Published: August 2020

El objetivo de este trabajo es tratar sobre el concepto la cultura en la generación conocida como los patriarcas o fundadores del pensamiento filosófico latinoamericano. Luego de establecer la relación entre la cultura la filosofía, y de justificar el recurso a los fundadores para tratar sobre el concepto de cultura, intentaré describir las características más importantes de la filosofía de algunos filósofos de esta generación, como Alejandro Korn, Carlos Vaz Ferreira, Alejandro Deústua, Enrique Molina y Antonio Caso, y señalar las principales ideas en torno al concepto de cultura, y su relación con la identidad latinoamericana.
An Uninfected Preterm Newborn Inadvertently Fed SARS-CoV-2–Positive Breast Milk
Authors: Lugli Licia , Bedetti Luca , Lucaccioni Laura , Gennari William , Leone Chiara , Ancora Gina , Berardi Alberto 
Published: August 2020

There are increasing concerns regarding coronavirus disease, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Approaches to breastfeeding and the management of neonates born to pauci-symptomatic mothers with coronavirus disease vary worldwide, although some scientific societies across Europe and the United States have emphasized the benefits of breastfeeding, even with expressed breast milk. Because SARS-CoV-2 has been, thus far, only exceptionally detected in breast milk, the risk of disease transmission has remained hypothetical.
We herein report the case of a healthy preterm newborn who was inadvertently fed SARS-CoV-2–positive breast milk. Two different samples, collected with and without strict hygiene precautions, were both confirmed to be SARS-CoV-2 positive. However, the newborn was not infected, supporting the protective role of breast milk. Furthermore, in this report, we highlight the difficulties in the practical management of a neonate whose breastfeeding mother was confirmed as positive for SARS-CoV-2 after delivery.
Inventario de Salud Mental – 5 (MHI-5) en adolescentes peruanos: estudio preliminar de validación
Authors: Merino-Soto Cesar , Cuba-Canales Yvette , Rojas-Aquiño Lucía 
Published: August 2020

Objetivo Dada la ausencia evidente de validaciones que repliquen la estructura interna del Inventario de Salud Mental –5(MHI-5) en adolescentes peruanos, el presente estudio realiza una evaluación preliminar de las propiedades psicométricas del MHI-5, específicamente de su estructura interna.Métodos La muestra fue de 75 estudiantes de ambos sexos de una institución educativa privada de nivel secundario del distrito de Casma (Lima, Perú). El análisis se realizó mediante la aplicación de un enfoque confirmatorio de análisis factorial dentro el modelamiento de ecuaciones estructurales.Resultados Se obtuvo que una sola dimensión significativa es viable para interpretar sus puntajes, pero el ajuste mejoró sustancialmente cuando de introdujo un factor que representó el efecto del fraseo negativo de dos ítems. Por otro lado, la consistencia interna fue mayor a 0,70, considerada como satisfactoria dada su brevedad.Conclusiones Se concluye que el MHI-5 mantiene la unidimensionalidad esencial, pero se requiere introducir el posible efecto del método debido al contenido de alguno de sus ítems. La confiabilidad de consistencia fue aceptable para propósitos de tamizaje. Se discuten los siguientes pasos para acumular más evidencias de validez, sugiriéndose desarrollar una versión más abreviada sin los ítems problemáticos, para reducir el potencial sesgo de respuesta.
Terapias biológicas del cáncer: un enfoque a favor de la accesibilidad
Authors: Aranda Monica Beatriz , Sabalette Karina B. 
Published: August 2020

Los anticuerpos monoclonales son una poderosa herramienta para el diagnóstico de laboratorio y un instrumento cada vez más utilizado en el tratamiento de diversas enfermedades, siendo uno de los grupos más importantes de drogas en el tratamiento del cáncer. La revolución en el mundo de los anticuerpos ocurre en 1975 cuando Milstein y Köhler desarrollan la técnica de las hibridomas en Cambridge.Objetivo Hacer una revisión del uso de anticuerpos monoclonales en medicina y, en particular, en el tratamiento del cáncer. Se busca aportar una visión generalizada del concepto de anticuerpo monoclonal para explicar su aplicabilidad terapéutica y abordar un enfoque económico y sociosanitario de la obtención y acceso a las nuevas terapias.Método En la caracterización del fenómeno de investigación se empleó el estudio descriptivo, de recolección de datos documental y la correlación entre las distintas fuentes.Discusión Son aún elevados los costos tanto para el paciente como para los sistemas de salud pública, y se ha de optimizar la valoración costo-efectividad de modo que la rentabilidad y el acceso a tiempo para los pacientes puedan ser compatibles. Se deja abierto el reto del desarrollo de nuevos mAbs dirigidos a nuevas dianas, mejorar el perfil de seguridad, evitando o reduciendo las reacciones adversas inmunes y conseguir el abaratamiento del coste de producción mediante mejoras en la biotecnología.
Communication Skills And Empathy Levels: The Case Of Health Department Students
Authors: ALPARSLAN Özgür , ALPARSLAN Ahmet 
Published: August 2020

Abstract:

Background/Aims:This study was carried out in cross-sectional and analytical type to
evaluate empathic tendency and communication skills in nursing and midwifery
students. Methods:

The sampling of the study consisted of 574 students. An information
form, the Communication Skills Assessment Scale, and the Empathic
Tendency Scale were used to collect the study data.

Results:The
mean score for empathic tendency was found to be 70.0±8.7, while it was
102.7±9.9 for Communication Skills Assessment Scale. The relationship between
the scores related to the two scales was determined to be positively significant
(p &lt;0.05). The demographic variables (age, gender, marital status) were
observed to have no effect on the mean scores for empathic tendency and Communication
Skills Assessment Scale (p&gt;0.05). No significant difference was found
between the scores obtained from the scales by the midwifery and nursing
students (p&gt; 0.05). There was no significant difference between the mean Empathic
Tendency Scale scores and years of nursing students (p&gt; 0.05). On the other
hand, the difference between the scale scores in both scales for students who
were satisfied, partly satisfied, and not satisfied with their profession was
significant (p &lt;0.01).Conclusions:

In conclusion, the empathic tendency and communication skill scores of
the students were found to be at a moderate level.
Does Anxiety Affect The Anesthesia Type Chosen By Cesarean Section Patients ?
Authors: TAPAR Hakan 
Published: August 2020

AbstractAim:The maternal anxiety associated with cesarean delivery is important issue. We aimed to assess whether the preoperative anxiety level of obstetric patients undergoing an elective caesarean sectionhas an effect on their decision regarding the choice of anesthesia.Methods:This study included 138 patients who were scheduled for electivecesarean section.The anesthesia type was chosen by patients. Patients were divided into two groups according to their choice: general anesthesia group (n=63) and spinal anesthesia group (n=75).Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI) and Pain Catastrophizing Scale (PCS) questionnaires were completed to measure participants’ psychological state. Patients were then assessed preoperatively, and demographic information was recorded.Results:The BAI and PCS scores were significantly higher in the general anesthesia group according to the spinal anesthesia group (p&lt;0.05). There was no difference between the two groups according to BDI (p&gt;0.05).Conclusion:The anxiety score was highin patients who chose to undergo general anesthesia.It was concluded that anxiety-related measures (during preoperative and postoperative period) should be considered in patients who prefer general anesthesia.