bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-oxidant activity of methanolic extract of aquatic flowering plant Nymphaea capensis leaf
Authors: Alam Mohammad , Biozid Md. Shahrear , Faruk Md. , Abeden Md. Jainul , Ferdous Khandoker Usran , Nitul Iffat Ara , Islam Md. Rafikul 
Published: April 2020

Abstract
Background: Nymphaea capensis is an aquatic flowering plant which is included in the family of Nymphaeaceae. Literature review on the plants of Nymphaeaceae family exhibited significant medicinal activities. Therefore, the objective of the present study is to evaluate possible anti-oxidant activity of crude methanol extract of N. capensis leaf.Method: In antioxidant study, methanolic plant extract was evaluated for 1,1-diphenyl,2-picrylhydrazyl (DPPH) and reducing power capacity. Moreover, total phenolic and total flavonoid content of plant extracts were determined and expressed in mg of gallic acid equivalent per gram of dry sample (mg GAE/g dry weight).Result: In the DPPH free radical scavenging assay, methanol extract showed concentration dependent inhibition of the free radicals. IC50 of Ascorbic acid was 14.84 µg/ml whereas N. capensis was 130.94 µg/ml. In case of reducing capacity, at conc. 62.5, 125, 250, 500, 1000 ug/ml, the absorbances of Ascorbic acid were 0.65, 1.12, 1.45, 1.78 and 1.89 respectively. In case of N. capensis, the absorbances were 0.46, 0.75, 1.04, 1.27 and 1.50 respectively. The extract displayed a concentration dependent increase in reducing power. In the case of total phenolic content, the methanol extract of N. capensis contained a considerable amount of phenolic contents which was 215±7 of GAE/g. In the case of total flavonoid content, methanol extract of N. capensis contained significant amount of flavonoid contents which was 184.75±6.78 of GAE/g.
A plausible path to contain the spread of 2019 Novel Coronavirus; a computational analysis prompts to the use of ACE2 receptor blockers
Authors: Whitman Christopher 
Published: April 2020

Abstract
Starting December 30th, 2019, a virus spread from Wuhan, in the Hubei Province of China. The virus had soon been recognized as part of the Coronavirus and temporarily named 2019 Novel Coronavirus. The dramatic increase of infections led to the death of over 400 people, by Feb 4th, 2020. By this day the virus had already crossed into 27 countries. March 11th, 2020 the World Health Organization declared the Novel Coronavirus a pandemic, pointing to over 118,000 cases of infections in over 110 countries. This public health threat drove the international community to real-time sharing of the genetic sequences isolated from the viruses. We used these freely accessible genetic data, while leveraging bioinformatic tools, with the intent to explore possible contributions to address this threat. Angiotensin-converting Enzyme 2 Inhibition has been proven to be a valuable strategy address the spread of SARS. After proving remarkable genetic similarities between SARS and the 2019 Novel Coronavirus, we computationally built the first known ex-novo model of the 2019 Novel Coronavirus Spike Glycoprotein entirely generated from its aminoacidic sequence, using I-TASEER. We then assessed the 2019 Novel Coronavirus interaction with the human Angiotensin-converting Enzyme 2. This research prompts at the potential use of Angiotensin- converting Enzyme 2 receptors blockers, as both clinical and prophylaxis measures to contain the spread of 2019 Novel Coronavirus.
In silico synergistic drug repurposing for combating novel coronavirus (COVID-19) outbreaks
Authors: Kim Minjee , Kim Young Bong 
Published: April 2020

Abstract
As the number of novel coronavirus (COVID-19) cases continues to rise, there is a global need for rapid drug development. In this study, we propose a systems pharmacology approach to reposition FDA-approved drug candidates for coronavirus, identify targets and suggest a synergistic drug combination using network pharmacology. We collected 67 genes associated with coronavirus, performed an enrichment analysis to obtain coronavirus-associated disease- pathway and constructed protein-protein interaction (PPI) network based on 67 genes. Total 37 significant disease-pathways were retrieved, and associated FDA-approved drugs were listed for drug repurposing candidates. Our PPI network showed 51 targets from 67 genes and identified IL6 and TNF as potential targets for coronavirus. From the FDA drug list, we selected four drugs that are experimentally used or studied for coronavirus to construct two- drug combinations. From six drug-drug networks, we identified hydroxychloroquine + ribavirin combination had the highest number of overlapping targets (IL6, IL2, IL10, CASP3, IFNA1) from PPI network target list, suggesting a potent synergistic drug combination for coronavirus. With the aim to support the rapid drug development, we suggest a new approach using systems-level drug repurposing for COVID-19 treatment.
Coronary microvascular obstruction (the no-reflow phenomenon) during percutaneous coronary interventions in patients with myocardial infarction
Authors: Frolov A. , Pochinka I. , Shahov B. , Sharabrin E. , Kuzymichev K. 
Published: April 2020

Coronary microvascular obstruction (the no-reflow phenomenon) after percutaneous coronary interventions in diagnosed with myocardial infarction has a significant negative impact on both the short-term and long-term prognosis. The mechanisms underlying this disorder are heterogeneous and complex, and as such it is difficult to devise effective treatments and/or to predict specific outcomes. Modern therapeutic approaches have indirect cardioprotective effects and certainly reduce the risk of no-reflow. However, attempts to create a drug or method that fundamentally improve the prognosis in patients with coronary microvascular obstruction have been unsuccessful. Thus, the problem of myocardial reperfusion damage has not been solved and further study will be necessary to provide support for the search for new therapeutic modalities. The purpose of this review is to provide an analysis of relevant literature that focuses on the aetiology, pathogenesis, diagnosis, prognosis and treatment of the coronary microvascular obstruction during and after percutaneous coronary interventions in patients diagnosed with myocardial infarction. We searched using the Medline (PubMed), RSCI (eLIBRARY), Embase and Google Scholar databases for all relevant literature pertaining to this subject.Received 13 January 2020. Accepted 11 February 2020.Funding: The study did not have sponsorship. Conflict of interest: Authors declare no conflict of interest.
Usability of Wearable Devices to Remotely Monitor Sleep Patterns Among Patients With Ischemic Heart Disease: Observational Study
Authors: Fortunato Michael , Adusumalli Srinath , Chokshi Neel , Harrison Joseph , Rareshide Charles , Patel Mitesh 
Published: April 2020

Background
There is growing interest in using wearable devices to remotely monitor patient behaviors. However, there has been little evaluation of how often these technologies are used to monitor sleep patterns over longer term periods, particularly among more high-risk patients.

Objective
The goal of the research was to evaluate the proportion of time that patients with ischemic heart disease used wearable devices to monitor their sleep and identify differences in characteristics of patients with higher versus lower use.

Methods
We evaluated wearable device data from a previously conducted clinical trial testing the use of wearable devices with personalized goal-setting and financial incentives. Patients with ischemic heart disease established a sleep baseline and were then followed for 24 weeks. The proportion of days that sleep data was collected was compared over the 24 weeks and by study arm. Characteristics of patients were compared to groups with high, low, or no sleep data.

Results
The sample comprised 99 patients with ischemic heart disease, among which 79% (78/99) used the wearable device to track their sleep. During the 6-month trial, sleep data were collected on 60% (10,024/16,632) of patient-days. These rates declined over time from 77% (4292/5544) in months 1 and 2 to 58% (3188/5544) in months 3 and 4 to 46% (2544/5544) in months 5 and 6. Sleep data were collected at higher rates among the intervention group compared with control (67% vs 55%, P<.001). In the main intervention period (months 3 and 4), patients with higher rates of sleep data were on average older (P=.03), had a history of smoking (P=.007), and had higher rates of commercial health insurance (P=.03).

Conclusions
Among patients with ischemic heart disease in a physical activity trial, a high proportion used wearable devices to track their sleep; however, rates declined over time. Future research should consider larger evaluations coupled with behavioral interventions.

Trial Registration
ClinicalTrials.gov NCT02531022; https://clinicaltrials.gov/ct2/show/NCT02531022
ESTUDO E TRABALHO NA EXPANSÃO DO ENSINO SUPERIOR NOTURNO: antigas dificuldades, novos enfrentamentos
Authors: Conceição Lourranny Santos Paixão da , Soares David Gonçalves 
Published: April 2020

Resenha do livro:CARVALHO, Gisele Francisca da Silva; DIAS, Rafaela Kelsen; SILVA, Rhuan Jonathan (Org.). A Tensa Relação entre o Trabalho e o Estudo no Brasil: os desafios enfrentados pelos estudantes do ensino técnico e superior noturno. São João del-Rei: EDIPET/IF SUDESTE, 2018.
Fenomena Penggunaan E-Wallet di Kalangan Pengusaha Warung Makan di Perkantoran Jakarta
Authors: Rudyanta Timotius 
Published: April 2020

Di Indonesia mulai bermunculan layanan keuangan berbasis digital, salah satunya adalah E-wallet. Go-Pay merupakan dompet virtual untuk menyimpan Go-Jek credit yang bisa digunakan untuk membayar transaksi. Go-Pay telah memperluas jangkauan hingga ke usaha mikro, kecil dan menengah di Indonesia. Fenomena ini menunjukkan adanya suatu perubahan dalam media pembayaran yang terjadi pada masa lampau dan masa kini. Hal ini karena adanya perubahan jaman, semua ingin lebih mudah seiring dengan majunya teknologi. Peneliti menggunakan teori Phenomology of Perception untuk mengungkapkan fenomena dengan cara melihat keterikatan antara individu tidak bisa dipisahkan karena individu melakukan interaksi. Peneliti menggunakan metode kualitatif karena ingin memahami fenomena scan QR code yang terjadi dengan menggunakan pemikiran Merleau Ponty. Unit analisisnya adalah persiapan pedagang UMKM dalam menghadapi fenomena pembayaran melalui scan QR code Go-Pay. Peneliti melakukan wawancara terhadap lima pemilik dan karyawan warung makan. Peneliti juga melakukan observasi atas hasil wawancara. Kesimpulan penelitian, banyak pedagang UMKM yang belum memahami fenomena Go-Pay ini disbanding dengan yang paham fenomena ini. Hal ini karena kurangnya perhatian dari Go-Pay dalam menjelaskan kegunaan dari scan QR Go-Pay kepada pedagang UMKM. Banyak pedagang UMKM yang mengikuti pedagang lainnya tanpa memahami kegunaan scan QR Go-Pay.
Strategi Komunikasi Pemasaran Novel Dilan: Dia adalah Dilanku tahun 1990
Authors: Musacarlos Petrus Finsensio , Hartanti Lisa Esti Puji 
Published: April 2020

Dalam berbagai usaha bisnis baik yang menghasilkan barang maupun jasa, peran pemasaran sangatlah penting karena merupakan salah satu faktor kunci keberhasilan bisnis. Novel Dilan: Dia adalah Dilanku tahun 1990, merupakan produk best seller di Indonesia yang dihasilkan dari strategi komunikasi pemasaran. Komunikasi pemasaran berperan penting dalam proses pembentukan persepsi konsumen dan membentuk perubahan perilaku konsumen sehingga terjadi tindakan pembelian terhadap sebuah produk yang dipasarkan. Tujuan penelitian ini adalah untuk menganalisis strategi komunikasi pemasaran yang dilakukan oleh penerbit Mizan terhadap novel Dilan: Dia adalah Dilanku tahun 1990. Penelitian ini menggunakan metode penelitian kualitatif dengan proses pengumpulan data yaitu dengan teknik wawancara, observasi, dan mengumpulkan data kepustakaan. Kemudian dijabarkan secara deskriptif dan dianalisis menggunakan teori strategi komunikasi pemasaran menurut Smith & Zook (2011) yang meliputi analisis situasi, tujuan, strategi, taktik, pelaksanaan, dan kontrol. Hasil penelitian ini adalah; strategi komunikasi pemasaran terhadap sebuah produk harus disusun dengan baik dan teliti, agar tujuan dan rencana atau strategi komunikasi pemasaran yang ingin dicapai dapat berhasil.
Lobby, neointitucionalismo e o processo decisório brasileiro
Authors: Graciano Monyele Camargo , Santos Leandro De Lima , Almeida Luiz Manoel de Moraes Camargo 
Published: April 2020

O presente artigo tem como escopo contribuir com a discussão a respeito das instituições informais no contexto brasileiro e também investigar o lobby como um modelo desse tipo de instituição no processo de tomada de decisão política, a partir da tipologia de Helmke e Levitsky. As instituições informais são concebidas como regras socialmente compartilhadas, não divulgadas por meios oficiais e são criadas e disseminadas marginalmente dos instrumentos formais, nesse sentido, a hipótese deste trabalho é que o lobby, concebido como uma atividade organizada voltada para a defesa de interesses específicos pode ser considerado um modelo de instituição informal. Para verificar tal hipótese, a metodologia empregada nesta pesquisa contou como uma abordagem qualitativa valendo-se de uma revisão bibliográfica acerca da temática proposta. Percebeu-se ao concluir a pesquisa, que o lobby é uma instituição informal, que dentre da tipologia proposta se enquadra como uma “instituição informal acomodada”.
Arts Day
Authors: Howard Natasha 
Published: April 2020

Healthcare staff wellbeing is linked to patient outcomes. Arts programmes have been shown to improve physical and emotional wellbeing in hospital staff. Starting in 2016 NELFT has delivered an annual one day creative arts festival known as Arts Day. Attendees self-rated their wellbeing on arrival, as they left and as part of a longer term follow up survey. There was an increase in the average self-rated wellbeing score after each Arts Day. The long term follow-up surveys show that attendees felt valued and enjoyed meeting up with colleagues. There is limited evidence of the long term impact of Arts Day. Less than 5% of NELFT staff have been released to attend the events. Future success will depend on integration with the wider wellbeing agenda and modifications to reach more staff.
Контроль якості електричних міжз’єднань гнучких структур
Authors: Невлюдов І.Ш. , Демська Н.П. , Разумов-Фризюк Є.А. , Новоселов С.П. 
Published: April 2020

Предметом статті є з’єднувач гнучких шлейфів для міжмодульних електричних з’єднань. Метою є представлення результатів експериментальних досліджень параметрів запропонованої конструкції з’єднувача гнучких комутаційних шлейфів при впливі динамічних навантажень, а також якості електричних з’єднань. Завдання: аналіз конструкційних особливостей основних типів з’єднувачів та причин виникнення відмов, експериментальне підтвердження теоретичних досліджень виконаних на попередніх етапах роботи та визначення експлуатаційних характеристик з’єднувача гнучких шлейфів для міжмодульних електричних з’єднань, проведення експерименту для отримання набору статистичних даних оцінки якості конструкції з’єднувача гнучких шлейфів. Використовуваними методами є: методи планування експерименту та обробки експериментальних даних. Отримані такі результати. Для поєднання двох шлейфів запропоновано нову конструкцію з’єднувача, яка дозволяє швидко та точно виконувати процес підмикання і гарантує якісне електричне з’єднання між контактами лінії зв’язку. В залежності від форми рисунку кришки можна досягти різних властивостей поєднання та якості з’єднання. Визначено вплив форми поверхні кришки з’єднувача на зусилля, що необхідне для механічного роз’єднання двох шлейфів в різні сторони. Визначено значення перехідного опору між контактами шлейфів. Висновки. Наукова новизна отриманих результатів полягає в наступному. Розроблений стенд для дослідження якості електричних міжз’єднань гнучких структур та методика проведення експериментальних досліджень дозволили експериментально довести якість запропонованої конструкції плаского з’єднувача гнучких шлейфів. Виходячи з отриманих результатів була визначена форма притискаючої кришки з’єднувача. Відповідно до результатів експерименту, кришка повинна мати шість або сім зубців. Встановлено, що максимальне зусилля, яке витримує з’єднувач, становить 1,3–1,4Н. Також показано, що перехідний опір в контактах з’єднувача становить максимум 0,2–0,3Ом. Експеримент показав надійність та стабільність параметрів при прикладенні механічних впливів та збереження протягом всіє другої стадії роботи з’єднувача, поки шлейф не зривається та не починає “ковзати” відносно нерухомого елементу конструкції.
Medicina de precisión en sepsis: utilidad de los biomarcadores en pacientes biomarcadores en pacientes críticamente enfermos
Authors: Molano Franco Daniel , Gómez Duque Mario , Beltrán Edgar , Villabón González Mario , Robayo Valbuena Ivan Felipe , Franco Luis Felipe , Cárdenas Colmenares Jorge Alberto , Estupiñán Monsalve Álvaro , Sánchez Vanegas Guillermo , Arévalo Rodriguez Ingrid , Zamora Romero Javier 
Published: April 2020

Durante años la evolución del cuidado intensivo ha intentado ofrecer una atención basada en protocolos y paquetes de manejo agrupados por patologías y cuadro sindromáticos. Aunque se logró disminuir la mortalidad en diferentes patologías (sepsis y síndromes coronario agudo y de distrés respiratorio agudo), no se han resuelto por completo los problemas clínicos, en especial el diagnóstico y el manejo. Una nueva opción ha surgido en el horizonte denominada “medicina de precisión”, entendida como estrategia de prevención y tratamiento que tiene en cuenta la variabilidad individual. La sepsis es un síndrome con múltiples aristas en cuanto al fenotipo y genotipo, cuyo diagnóstico temprano es relevante para los desenlaces clínicos. Hasta el momento el enfoque principal ha sido la identificación de un germen etiológico para diferenciarla del síndrome de respuesta inflamatoria sistémica (SIRS). En los últimos años el paradigma en enfermedades infecciosas ha cambiado debido a estudios que demuestran como la respuesta inmunitaria del paciente séptico tiene un papel clave en el desarrollo de la enfermedad, con implicaciones en el diagnóstico, pronóstico y tratamiento, que podrían ayudar a cambiar el abordaje en los próximos años gracias a una estrategia basada en medicina de precisión. Hoy los aislamientos microbiológicos y los cultivos siguen siendo el estándar de referencia con varias desventajas como el tiempo para obtener resultados, sobre todo en infecciones por gérmenes resistentes u hongos, que pueden retrasar el inicio de la terapia antimicrobiana. Como alternativa se ha planteado el uso de biomarcadores en sepsis que siendo productos de la respuesta inflamatoria del individuo ante la infección, son útiles para el diagnóstico y pronóstico primordialmente en los críticamente enfermos. Decidimos realizar esta revisión narrativa acerca de la utilidad de los biomarcadores en pacientes con sepsis críticamente enfermos, para enfocarlos en un modelo de medicina personalizada.
MBSE-Entwicklungsfähigkeit für Digitale Zwillinge
Authors: Zimmermann Thomas C. , Masuhr Christian , Stark Rainer 
Published: April 2020

Kurzfassung
Das Konzept des Digital Twins nutzt Modelle über die Entwicklung und Absicherung hinaus auch für Betriebsoptimierungen. Modellbasiertes Systems Engineering (MBSE) ermöglicht eine durchgängige Systemmodellierung mit offenen Schnittstellen für die Systementwicklung. Dieser Beitrag stellt an einem beispielhaften IoT-Pumpensystem Schnittstellenerweiterungen vor, um MBSE für eine durchgängige Modellierung, von der Entwicklung über den Betrieb bis End-of-Life, nutzen zu können. Die gewonnenen Informationen können zurückgeführt und für zukünftige Produktneuentwicklungen genutzt werden.
Digitaler Zwilling für die Produktionstechnik – auf die Nutzung kommt es an
Authors: Mewes Jürgen , Justus Andrej 
Published: April 2020

Kurzfassung
Die Inbetriebnahme vor Ort ist stets ein zentraler Punkt bei der Entwicklung von Maschinen und Anlagen. Mit WinMOD-Systemplattform von Mewes & Partner GmbH werden Bedingungen geschaffen, Maschinen und Anlagen so zu virtualisieren, dass sie mit realen Automatisierungssystemen in Betrieb genommen werden können. Die gesamte Technik und Technologie lassen sich somit auf einer Plattform abbilden.
Mit flexibler Architektur zum Digital Twin
Authors: Müller Andreas 
Published: April 2020

Kurzfassung
Der Digital Twin soll Unternehmen über Closed-Loop-Zugriffe wertvolle Einblicke in allen Phasen des Lifecycles geben. Dadurch lassen sich in sämtlichen Bereichen, von der Entwicklung bis zur Wartung, erhebliche Einsparungen erzielen und neue Geschäftsmodelle etablieren. In der Praxis scheitern jedoch viele entsprechende Initiativen, weil keine Aktualisierungen von Metadatenmodellen erfolgen. Die Ursache dafür ist häufig eine schlecht integrierte PLM-Software. Gefragt sind deshalb Lösungen, die komplett selbst anpassbar sind und einen durchgehenden Blick auf sämtliche Daten liefern.
Digitaler Zwilling und Produktion 4.0
Authors: Himstedt Steffen 
Published: April 2020

Kurzfassung
Der Digitale Zwilling ist einer der am häufigsten benutzten Begriffe im Umfeld Industrie 4.0 und digitaler Transformation. Fragt man jedoch nach, was unter dem Digitalen Zwilling eigentlich zu verstehen ist, erhält man unterschiedliche Antworten. Der Bezug auf das 3-D-Modell des Produkts ist dabei das vorherrschende Beispiel, darauf aufbauend dann Anwendungen der virtuellen oder erweiterten Realität für Instandhaltung und Service. Dabei liegen, wie bei einem Eisberg, 90 Prozent der Daten und Prozesse, die einen Digitalen Zwilling repräsentieren, häufig nicht im Blick der Beteiligten. Wie sieht also eine ganzheitliche Perspektive über Wertschöpfungsstufen und Systemgrenzen hinweg aus?
Digital Twin für maximale Cyber Security
Authors: Krüger Jens 
Published: April 2020

Kurzfassung
Die Digitalisierung in der Automobilindustrie macht Cyber Security bei Fahrzeug-Software-Updates zum Fokusthema – internationale Regulierungsgremien arbeiten dazu gerade Sicherheitsrichtlinien aus. Für Fahrzeughersteller bedeutet das, dass sie schnellstmöglich Prozesse und Systeme gemäß den neuen Cyber-Security-Vorgaben etablieren müssen. „Digital Twin Computing“ kann hier wesentlich unterstützen. Die neue Initiative aus Japan ist mehr als das, was gemeinhin unter einem Digitalen Zwilling verstanden wird.
Digital Twin und PLM als Teil der Unternehmensstrategie
Authors: Sieg Olaf , Völl Christian 
Published: April 2020

Kurzfassung
Der Digital Twin ist auf der Agenda der produzierenden Industrieunternehmen längst vorhanden. Dennoch stecken Implementierungsprojekte dazu immer noch in den Anfängen. Dieser Beitrag diskutiert den Zusammenhang zwischen PLM und dem Digital Twin als zentrale Informationsquelle im Unternehmen.
Viel mehr als ein 3D-Modell
Authors: Lindermayr Jochen 
Published: April 2020

Kurzfassung
Schnell verfügbare und hochwertige Daten sind ein Schlüsselelement für digitale Abbilder von Objekten. Das Fraunhofer-Institut für Produktionstechnik und Automatisierung IPA hat deshalb Verfahren und Softwaretechnologien entwickelt, die das Modellieren und Erkennen von beliebigen Objekten in 3D in sehr kurzer Zeit und die Analyse ihrer Informationen wie Stammdaten, Farben und Struktur ermöglichen. Jetzt bringt das Institut die Technologien in das große KI-Forschungsprojekt „Knowledge4Retail“ ein.