bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D printed CT-based abdominal structure mannequin for enabling research
Authors: Anwari Vahid , Lai Ashley , Ursani Ali , Rego Karina , Karasfi Behruz , Sajja Shailaja , Paul Narinder 
Published: February 2020

AbstractAn anthropomorphic phantom is a radiologically accurate, tissue realistic model of the human body that can be used for research into innovative imaging and interventional techniques, education simulation and calibration of medical imaging equipment. Currently available CT phantoms are appropriate tools for calibration of medical imaging equipment but have major disadvantages for research and educational simulation. They are expensive, lacking the realistic appearance and characteristics of anatomical organs when visualized during X-ray based image scanning. In addition, CT phantoms are not modular hence users are not able to remove specific organs from inside the phantom for research or training purposes. 3D printing technology has evolved and can be used to print anatomically accurate abdominal organs for a modular anthropomorphic mannequin to address limitations of existing phantoms. In this study, CT images from a clinical patient were used to 3D print the following organ shells: liver, kidneys, spleen, and large and small intestines. In addition, fatty tissue was made using modelling beeswax and musculature was modeled using liquid urethane rubber to match the radiological density of real tissue in CT Hounsfield Units at 120kVp. Similarly, all 3D printed organ shells were filled with an agar-based solution to mimic the radiological density of real tissue in CT Hounsfield Units at 120kVp. The mannequin has scope for applications in various aspects of medical imaging and education, allowing us to address key areas of clinical importance without the need for scanning patients.
Chinese practices of The Initiative on Promoting Inter-ethnic Unity and Common Progress
Authors: Sui Qing , Li Zhongxie , Sun Shuyi , Li Shiqiang , Chen Danhong 
Published: February 2020

AbstractThe work of Initiative on Promoting Inter-ethnic Unity and Common Progress (hereinafter referred to as “The Initiative Work”) originated from long-term historical practice and is a significant measure for China to promote inter-ethnic unity and progress. This article sorts out the development process of The Initiative Work in China, introduces the progress of its demonstration regions and units, elaborates the practices of The Initiative Work in the following aspects: consolidation of the top-level design, improvement of the quality and coverage, publicity of the national policies, cultivation of the demonstration models, management by the laws, and strengthening theoretical studies. This article also analyzes the shortcomings and challenges faced by the current work.
New mHealth application software based on myofunctional therapy applied to sleep-disordered breathing in non-compliant subjects
Authors: O’Connor Reina Carlos , Plaza Guillermo , Ignacio-Garcia Jose Maria , Baptista Jardin Peter , Garcia-Iriarte Maria Teresa , Casado-Morente Juan Carlos , De Vicente Gonzalez Eugenio , Rodriguez-Reina Agustin 
Published: February 2020

Abstract
Background
Myofunctional therapy (MT) is a therapeutic option with demonstrated efficacy for treating sleep-disordered breathing. We assessed the clinical application of a newly developed m-Health App, which aimed to allow patients with OSAHS (obstructive sleep apnea/hypopnea syndrome) to perform oropharyngeal exercises only by interacting with their smartphone without no other devices.

Methods
We offered to treat the OSAHS of 20 patients with the App for 90 sessions. Inclusion criteria were adult patients diagnosed with OSAHS who rejected, or could not tolerate or afford treatment for their OSAHS with other modalities. The App was used by 15 patients, while 5 were noncompliant and then were used as a control group. Polygraphy was performed at the beginning of the study, and after 90 sessions in the App group or after 3 months in the control group. Data for adherence to treatment, sex, body mass index (BMI), age, O2MIN (oxygen minimal saturation) and apnea–hypopnea index (AHI) were collected for both groups.

Results
15 (75%) patients showed adherence to the treatment as measured as performing the exercises daily 5 days a week. In patients who performed the exercises, AHI decreased from 25.78 ± 12.6 to 14.1 ± 7,7 (p = 0.002), Epworth changed from 18,2 ± 1,98 to 14,2 ± 7,7(p = 0,002) and (O2MIN) changed from 84,87 ± 7.02 to 89,27 ± 3,77 (p = 0.0189). In the control group, there was no significant change.

Conclusions
To our knowledge, this is the first study reported where a mHealth App based on MT could be by itself a therapeutic option in selected patients with OSAHS.
Variation in gut bacterial composition is associated with Haemonchus contortus parasite infection of sheep
Authors: Mamun Md. Abdullah Al , Sandeman Mark , Rayment Phil , Brook-Carter Phillip , Scholes Emily , Kasinadhuni Naga , Piedrafita David , Greenhill Andrew R. 
Published: February 2020

AbstractBackgroundOne of the greatest impediments to global small ruminant production is infection with the gastrointestinal parasite,Haemonchus contortus. In recent years there has been considerable interest in the gut microbiota and its impact on health. Relatively little is known about interactions between the gut microbiota and gastrointestinal tract pathogens in sheep. Thus, this study was undertaken to investigate the link between the faecal microbiota of sheep, as a sample representing the gastrointestinal microbiota, and infection withH. contortus.ResultsSheep (n = 28) were experimentally inoculated with 14,000H. contortusinfective larvae. Faecal samples were collected 4 weeks prior to and 4 weeks after infection. Microbial analyses were conducted using automated ribosomal intergenic spacer analysis (ARISA) and 16S rRNA gene sequencing. A comparison of pre-infection microbiota to post-infection microbiota was conducted. A high parasite burden associated with a relatively large change in community composition, including significant (p ≤ 0.001) differences in the relative abundances of Firmicutes and Bacteroidetes following infection. In comparison, low parasite burden associated with a smaller change in community composition, with the relative abundances of the most abundant phyla remaining stable. Interestingly, differences were observed in pre-infection faecal microbiota in sheep that went on to develop a high burden ofH. contortusinfection (n = 5) to sheep that developed a low burden of infection (n = 5). Differences observed at the community level and also at the taxa level, where significant (p ≤ 0.001) in relative abundance of Bacteroidetes (higher in high parasite burden sheep) and Firmicutes (lower in high parasite burden sheep).ConclusionsThis study reveals associations between faecal microbiota and high or lowH. contortusinfection in sheep. Further investigation is warranted to investigate causality and the impact of microbiome manipulation.
RAMAN AND ATR-FTIR SPECTROSCOPY TOWARDS CLASSIFICATION OF WET BLUE BOVINE LEATHER USING RATIOMETRIC AND CHEMOMETRIC ANALYSIS
Authors: Mehta Megha , Naffa Rafea , Maidment Catherine , Holmes Geoff , Waterland Mark 
Published: February 2020

Abstract
There is a substantial loss of value in bovine leather every year due to a leather quality defect known as “looseness”. Data show that 7% of domestic hide production is affected to some degree, with a loss of $35 m in export returns. This investigation is devoted to gaining a better understanding of tight and loose wet blue leather based on vibrational spectroscopy observations of its structural variations caused by physical and chemical changes that also affect the tensile and tear strength. Several regions from the wet blue leather were selected for analysis. Samples of wet blue bovine leather were collected and studied in the sliced form using Raman spectroscopy (using 532 nm excitation laser) and Attenuated Total Reflectance - Fourier Transform InfraRed (ATR-FTIR) spectroscopy. The purpose of this study was to use ATR-FTIR and Raman spectra to classify distal axilla (DA) and official sampling position (OSP) leather samples and then employ univariate or multivariate analysis or both. For univariate analysis, the 1448 cm− 1 (CH2 deformation) band and the 1669 cm− 1 (Amide I) band were used for evaluating the lipid-to-protein ratio from OSP and DA Raman and IR spectra as indicators of leather quality. Curve-fitting by the sums-of-Gaussians method was used to calculate the peak area ratios of 1448 and 1669 cm− 1 band. The ratio values obtained for DA and OSP are 0.57 ± 0.099, 0.73 ± 0.063 for Raman and 0.40 ± 0.06 and 0.50 ± 0.09 for ATR-FTIR. The results provide significant insight into how these regions can be classified. Further, to identify the spectral changes in the secondary structures of collagen, the Amide I region (1600–1700 cm− 1) was investigated and curve-fitted-area ratios were calculated. The 1648:1681 cm− 1 (non-reducing: reducing collagen types) band area ratios were used for Raman and 1632:1650 cm− 1 (triple helix: α-like helix collagen) for IR. The ratios show a significant difference between the two classes. To support this qualitative analysis, logistic regression was performed on the univariate data to classify the samples quantitatively into one of the two groups. Accuracy for Raman data was 90% and for ATR-FTIR data 100%. Both Raman and ATR-FTIR complemented each other very well in differentiating the two groups. As a comparison, and to reconfirm the classification, multivariate analysis was performed using Principal Component Analysis (PCA) and Linear Discriminant Analysis (LDA). The results obtained indicate good classification between the two leather groups based on protein and lipid content. Principal component score 2 (PC2) distinguishes OSP and DA by symmetrically grouping samples at positive and negative extremes. The study demonstrates an excellent model for wider research on vibrational spectroscopy for early and rapid diagnosis of leather quality.

Graphical abstract
A new genus and species of foliicolous lichen in a new family of Strigulales (Ascomycota: Dothideomycetes) reveals remarkable class-level homoplasy
Authors: Jiang Shu Hua , Hawksworth David L. , Lücking Robert , Wei Jiang Chun 
Published: February 2020

AbstractPhylogenetic analysis of some foliicolous lichens collected in Hainan Province, China, revealed a new lineage morphologically similar to Porina but phylogenetically related to Strigulaceae (Dothideomycetes), differing from the latter in ascus type. The monospecific genus Tenuitholiascus gen. nov. is introduced for the single species, T. porinoides sp. nov., which is placed in the new, monogeneric family Tenuitholiascaceae, sister to Strigulaceae in Strigulales. The new taxon closely resembles the genus Porina in external morphology and ascospore type, as well as the thin-walled asci and unbranched paraphyses. Yet, it is entirely unrelated to the latter, which belongs in class Lecanoromycetes in the order Gyalectales.
Assisted reproductive technology and the risk of gestational diabetes mellitus: a systematic review and meta-analysis
Authors: Mohammadi Maryam , Khedmati Morasae Esmaeil , Maroufizadeh Saman , Almasi-Hashiani Amir , Navid Behnaz , Amini Payam , Omani-Samani Reza , Alizadeh Ahad 
Published: February 2020

Abstract
Background
The use of assisted reproductive technology (ART) is increasing worldwide, and observational studies have indicated that women who conceived by ART have an increased risk of pregnancy complications including gestational diabetes mellitus (GDM). We aimed to determine the risk of GDM among women who conceived with ART by systematic review and meta-analysis.

Main text
A systematic literature search was conducted in ISI Web of Knowledge, MEDLINE, Scopus, and Embase through May 2017 for English-language articles using a list of keywords. All studies comparing GDM in women conceived by ART and those who conceived spontaneously were included. Data extraction was performed by two authors independently and discrepancies were resolved by discussion. In total, 48 studies with 91,487 pregnancies conceived through ART and 2,525,234 spontaneously conceived met the inclusion criteria. There was evidence of substantial heterogeneity among these studies (P < 0.001, I2 = 98.6%). Random effects meta-analysis showed a significant increase in GDM among those who conceived by ART compared with those who conceived spontaneously (pooled relative risk = 1.51, 95% confidence interval = 1.18–1.93). Visual inspection of the funnel plot did not reveal any publication bias, which was supported by Egger’s test and Begg’s test.

Conclusion
The findings of this systematic review indicate that the use of ART treatment is associated with a 1.51-fold increase in GDM. Women need to be counselled carefully before undergoing ART treatment about the possibility and risk of GDM.
Influence of chronotype on daily mood fluctuations: pilot study in patients with depression
Authors: Brückmann Konstantin F. , Hennig Jürgen , Müller Matthias J. , Fockenberg Stanislava , Schmidt Anne-Marthe , Cabanel Nicole , Kundermann Bernd 
Published: February 2020

Summary
Depression risk is associated with a late chronotype pattern often described as an ‘evening chronotype’. Fluctuations in mood over consecutive days have not yet been measured according to chronotype in in-patients with depression. A total of 30 in-patients with depression and 32 healthy controls matched for gender and age completed a chronotype questionnaire and twice-daily ratings on mood for 10 consecutive days (registered in the German Clinical Trials Register: DRKS00010215). The in-patients had Saturdays and Sundays as hospital-leave days. The relationship between chronotype and daily mood was mediated by the weekday–weekend schedule with higher levels of negative affect in the evening-chronotype patient subgroup at weekends. Results are discussed with respect to a probably advantageous standardised clinical setting with early morning routines, especially for patients with evening chronotypes.
Staff training in positive behaviour support for behaviour that challenges in people with intellectual disability: cost-utility analysis of a cluster randomised controlled trial
Authors: Hunter Rachael Maree , Vickerstaff Victoria , Poppe Michaela , Strydom Andre , King Michael , Hall Ian , Crabtree Jason , Omar Rumana , Cooper Vivien , Biswas Asit , Hassiotis Angela 
Published: February 2020

Background
Behaviour that challenges in people with intellectual disability is associated with higher healthcare, social care and societal costs. Although behavioural therapies are widely used, there is limited evidence regarding the cost and quality-adjusted life-years (QALYs).

Aims
We aimed to assess the incremental cost per QALY gained of therapist training in positive behaviour support (PBS) and treatment as usual (TAU) compared with TAU using data from a cluster randomised controlled trial (Clinical Trials.gov registration: NCT01680276).

Method
We conducted a cost-utility analysis (cost per QALY gained) of 23 teams randomised to PBS or TAU, with a total of 246 participants followed up over 36 months. The primary analysis was from a healthcare cost perspective with a secondary analysis from a societal cost perspective.

Results
Over 36 months the intervention resulted in an additional 0.175 QALYs (discounted and adjusted 95% CI −0.068 to 0.418). The total cost of training in and delivery of PBS is £1598 per participant plus an additional cost of healthcare of £399 (discounted and adjusted 95% CI −603 to 1724). From a healthcare cost perspective there is an 85% probability that the intervention is cost-effective compared with TAU at a £30 000 willingness to pay for a QALY threshold.

Conclusions
There was a high probability that training in PBS is cost-effective as the cost of training and delivery of PBS is balanced out by modest improvements in quality of life. However, staff training in PBS is not supported given we found no evidence for clinical effectiveness.
Role of Hospice Care at the End of Life for People With Cancer
Authors: Currow David C. , Agar Meera R. , Phillips Jane L. 
Published: February 2020

Patient-defined factors that are important at the end of life include being physically independent for as long as possible, good symptom control, and spending quality time with friends and family. Hospice care adds to the quality of care and these patient-centered priorities for people with cancer and their families in the last weeks and days of life. Evidence from large observational studies demonstrate that hospice care can improve outcomes directly and support better and more appropriate health care use for people in the last stages of cancer. Team-based community hospice care has measurable benefits for patients, their family caregivers, and health services. In addition to improved symptom control for patients and a greater likelihood of time spent at home, caregiver outcomes are better when hospice care is accessed: informational needs are better met, and caregivers have an improved ability to move on with life after the patient’s death compared with people who did not have access to these services. Hospice care continues to evolve as its reach expands and the needs of patients continue to broaden. This is reflected in the transition from hospice being based on excellence in nursing to teams with a broad range of health professionals to meet the complex and changing needs of patients and their families. Additional integration of cancer services with hospice care will help to provide more seamless care for patients and supporting family caregivers during their caregiving and after the death of the patient.
Impact of Merit-Based Immigration Policies on Brain Drain From Low- and Middle-Income Countries
Authors: El Saghir Nagi S. , Anderson Benjamin O. , Gralow Julie , Lopes Gilberto , Shulman Lawrence N. , Moukadem Hiba A. , Yu Peter Paul , Hortobagyi Gabriel 
Published: February 2020

PURPOSE Brain drain is the migration of educated and skilled individuals from a less developed region or country to a more economically established one. The Trump administration proposed a merit-based immigration plan. This article addresses its potential impact on health care delivery in low- and middle-income countries (LMICs) and their preparedness to deal with it. MATERIALS AND METHODS Data on immigration policies, numbers of international medical graduates practicing in high-income countries (HICs), various scientific exchange methods, and efforts for capacity building in LMICs. RESULTS Talented individuals seek to advance their knowledge and skills, and may stay in HICs because of greater rewards and opportunities. HICs also rely on immigrant international medical graduates to supplement their physician workforces. CONCLUSION Ambitious individuals from LMICs need and should have opportunities to advance their education and training in more advanced countries. LMICs should increase their educational efforts, research capabilities, infrastructures, and living conditions to better serve their own populations and reduce their brain drain phenomenon.
Pre-operative CT localization for patients with subsolid opacities expecting video-assisted thoracoscopic surgery—single center experience of fluorescent iodized emulsion and hook-wire localization technique
Authors: Li Allen , Chan S , Thung KH 
Published: February 2020

Objective:
To describe our clinical experience of using combination of fluorescent iodized emulsion, indocyanine green & lipiodol, and hook-wire in pre-operative CT localization of patients with subsolid lung lesions prior to video-assisted thoracoscopic surgery (VATS).

Methods:
A retrospective review between June 2018 and July 2019 of consecutive Chinese patients whom underwent VATS for subsolid lung lesions with pre-operative CT localization done with combination of fluorescent iodized emulsion and hook-wire technique in a tertiary hospital (Tuen Mun Hospital, Hong Kong SAR). The duration and complications related to the localization procedure were recorded The clinical records, operative findings and pathology reports were retrieved from the hospital electronic clinical management system.

Results:
Combination fluorescent iodized emulsion with hook-wire enabled accurate localization and resection of all subsolid lung lesions in VATS. No major complications were reported.

Conclusion:
Combination of fluorescent iodized emulsion and hook-wire placement under CT guidance is a simple, safe and cost- effective procedure that enabled accurate localization and resection of subsolid nodule in VATS.

Advances in knowledge:
VATS has been the mainstay for indeterminate pulmonary nodules for diagnostic and/or curative purpose. The main problem that surgeons may encounter during operation is the difficulty in locating the target lesion particularly for subsolid lesions. Many pre-operative localization methods have been developed in this regard. With the novel technique that we described, we were able to overcome disadvantages of most described methods.
Diversity and distribution of fish fauna of upstream and downstream areas at Koto Panjang Reservoir, Riau Province, Indonesia
Authors: Aryani Netti , Suharman Indra , Azrita Azrita , Syandri Hafrijal , Mardiah Ainul 
Published: February 2020

Background: The capture fishery sectors in the river and reservoir play an important role in the Indonesian economy through increased income and diversification of livelihoods. The present study was conducted to ascertain fish diversity and their distribution pattern in the upstream and downstream areas of Koto Panjang Reservoir, Riau Province-Indonesia. Methods: Fish samples were collected for a period of 12 months using a variety of fish nets at four sites; Koto Mesjid (KM) and Batu Bersurat (BB), located in the upstream area of Koto Panjang Reservoir and Rantau Berangin (RB) and Kuok (KK), located in the downstream area of Koto Panjang Reservoir. Data obtained were analyzed using standard taxonomic keys based on morphometric characters. Results: A total of 44 species belonging 19 families and 33 genera were recorded in the study area. Alpha diversity indices showed that fish diversity in this area was quite high (Shannon’s index = 2.10 and Simpson-D = 0.21) and evenness was low (evenness H/S =0.19). The ﬁsh in KM and BB sites (upstream) were from eight and 11 families, respectively. In RB and KK sites (downstream), fish were from 16 and 15 families, respectively. In KM, BB, RB and KK sites, the dominant family was Cyprinidae, comprising 33.45%, 50.95%, 43.04% and 39.35% of all fish caught at each site, respectively. Exotic species, especially Nile tilapia, were 20.15%, 14.11%, 5.62%, and 5.34%, respectively. Some differences were also noted between the upstream and downstream reservoirs, with a slight increase in exotic species in the upstream reservoir over the study period (from 11.39% vs. 34.66%), corresponding to decrease of native species (from 88.61% vs. 65.34%). Conclusions: The diversity and distribution of fish fauna were varied in upstream and downstream areas of Koto Panjang Reservoir. The exotic species were found to be dominant in the upstream reservoir areas.