bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is the Ocean Speeding Up? Ocean Surface Energy Trends
Authors: Wunsch Carl 
Published: September 2020

AbstractA recent paper by Hu et al. (https://doi.org/10.1126/sciadv.aax7727) has raised the interesting question of whether the ocean circulation has been “speeding up” in the last decades. Their result contrasts with some estimates of the lack of major trends in oceanic surface gravity waves and wind stress. In general, both the increased energy and implied power inputs of the calculated circulation correspond to a small fraction of the very noisy background values. An example is the implied power increase of about 3 × 108 W, as compared to wind energy inputs of order 1012 W. Here the problem is reexamined using a state estimate that has the virtue of being energy, mass, etc. conserving. Because it is an estimate over an entire recent 26-yr interval, it is less sensitive to the strong changes in observational data density and distribution, and it does not rely upon nonconservative “reanalyses.” The focus is on the energy lying in the surface layers of the ocean. A potential energy increase is found, but it is almost completely unavailable—arising from the increase in mean sea level. A weak increase in kinetic energy in the top layer (10 m) is confirmed, corresponding to an increase of order 1 cm s−1 yr−1 over 26 years. An estimate of kinetic energy in the full water column shows no monotonic trend, but the changes in the corresponding available potential energy are not calculated here.
Nowcasting Multicell Short-Term Intense Precipitation Using Graph Models and Random Forests
Authors: Wang Cong , Wang Ping , Wang Di , Hou Jinyi , Xue Bing 
Published: September 2020

AbstractShort-term intense precipitation (SIP; i.e., convective precipitation exceeding 20 mm h−1) nowcasting is important for urban flood warning and natural hazards management. This paper presents an algorithm for coupling automatic weather station data and single-polarization S-band radar data with a graph model and a random forest for the nowcasting of SIP. Different from the pixel-by-pixel precipitation nowcasting algorithm, this algorithm takes the convective cells as the basic units to consider their interactions and focuses on multicell convective systems. In particular, the following question could be addressed: Will a multicell convective system cause SIP events in the next hour? First, a method based on spatiotemporal superposition between cells is proposed for multicell systems identification. Then, the graph model is used to represent cell physical attributes and the spatial distribution of the entire system. For each graph model, a fusion operation is used to form a 42-dimensional graph feature vector. Finally, combined with the machine learning approaches, a random forest classifier is trained with the graph feature vector to predict the precipitation. In the experiment, this algorithm achieves a probability of detection (POD) of 79.2% and a critical success index (CSI) of 68.3% with the data between 2015 and 2016 in North China. Compared with other precipitation nowcasting algorithms, the graph model and random forest could predict SIP events more accurately and produce fewer false alarms.
The Effects of Allogeneic Blood Transfusion in Hepatic Resection
Authors: Inoue Yoshihiro , Ishii Masatsugu , Fujii Kensuke , Kitada Kazuya , Kuramoto Toru , Takano Yoshiaki , Matsuo Kentaro , Tomioka Atsushi , Yamaguchi Toshifumi , Yokohama Keisuke , Ohama Hideko , Harada Satoshi , Osumi Wataru , Tsuchimoto Yusuke , Terazawa Tetsuji , Ogura Takeshi , Masubuchi Shinsuke , Yamamoto Masashi , Imoto Akira , Asai Akira , Shirai Yasutsugu , Inoue Masaya , Fukunishi Shinya , Goto Masahiro , Higuchi Kazuhide , Uchiyama Kazuhisa 
Published: September 2020

Background Hepatectomy has a high risk of perioperative bleeding due to the underlying disease. Here, we investigated the postoperative impact of allogeneic blood transfusion during hepatectomy. Methods The surgical outcomes in 385 patients who underwent hepatic resection for hepatocellular carcinoma were retrospectively reviewed. The association of allogeneic blood transfusion with surgical outcomes and remnant liver regeneration data was analyzed. Results Eighty-six patients (24.0%) received an allogeneic blood transfusion and 272 patients (76.0%) did not. After propensity score matching, the incidence rates of postoperative complication (Clavien-Dindo grade >IIIA), posthepatectomy liver failure, and massive ascites were significantly higher for the group that received a blood transfusion than for the group that did not receive blood transfusion ( P < .001, P = .001, and <.001, respectively). Postoperative measures of total bilirubin, albumin, platelet count, prothrombin time, aspartate aminotransferase, and alanine aminotransferase were significantly more favorable in patients without blood transfusion until day 7 after surgery. There were no correlations in the remnant liver regeneration at 7 days, and 1, 2, 5, and 12 months postoperatively between the 2 groups ( P = .585, .383, .507, .261, and .430, respectively). Regarding prognosis, there was no significant difference in overall and recurrence-free survival between the 2 groups ( P = .065 and .166, respectively). Conclusion Allogeneic transfusion during hepatectomy strongly affected remnant liver function in the early postoperative period; however, this was not related to the remnant liver regeneration volume. Despite that the allogeneic transfusion resulted in poorer postoperative laboratory test results and increased postoperative complication and mortality rates, it had no effect on the long-term prognosis.
The physical health of Māori with bipolar disorder
Authors: Cunningham Ruth , Stanley James , Haitana Tracy , Pitama Suzanne , Crowe Marie , Mulder Roger , Porter Richard , Lacey Cameron 
Published: September 2020

Aims: There is very little empirical evidence about the relationship between severe mental illness and the physical health of Indigenous peoples. This paper aims to compare the physical health of Māori and non-Māori with a diagnosis of bipolar disorder in contact with NZ mental health services. Methods: A cohort of Māori and non-Māori with a current bipolar disorder diagnosis at 1 January 2010 were identified from routine mental health services data and followed up for non-psychiatric hospital admissions and deaths over the subsequent 5 years. Results: Māori with bipolar disorder had a higher level of morbidity and a higher risk of death from natural causes compared to non-Māori with the same diagnosis, indicating higher levels of physical health need. The rate of medical and surgical hospitalisation was not higher among Māori compared to non-Māori (as might be expected given increased health needs) which suggests under-treatment of physical health conditions in this group may be a factor in the observed higher risk of mortality from natural causes for Māori. Conclusion: This study provides the first indication that systemic factors which cause health inequities between Māori and non-Māori are compounded for Māori living with severe mental illness. Further exploration of other diagnostic groups and subgroups is needed to understand the best approach to reducing these inequalities.
Cognitive behavioural therapy for chronic fatigue and chronic fatigue syndrome: outcomes from a specialist clinic in the UK
Authors: Adamson James , Ali Sheila , Santhouse Alastair , Wessely Simon , Chalder Trudie 
Published: September 2020

Objectives Cognitive behavioural therapy is commonly used to treat chronic fatigue syndrome and has been shown to be effective for reducing fatigue and improving physical functioning. Most of the evidence on the effectiveness of cognitive behavioural therapy for chronic fatigue syndrome is from randomised control trials, but there are only a few studies in naturalistic treatment settings. Our aim was to examine the effectiveness of cognitive behavioural therapy for chronic fatigue syndrome in a naturalistic setting and examine what factors, if any, predicted outcome. Design Using linear mixed effects analysis, we analysed patients' self-reported symptomology over the course of treatment and at three-month follow-up. Furthermore, we explored what baseline factors were associated with improvement at follow-up. Setting Data were available for 995 patients receiving cognitive behavioural therapy for chronic fatigue syndrome at an outpatient clinic in the UK. Participants Participants were referred consecutively to a specialist unit for chronic fatigue or chronic fatigue syndrome. Main outcome measures Patients were assessed throughout their treatment using self-report measures including the Chalder Fatigue Scale, 36-item Short Form Health Survey, Hospital Anxiety and Depression Scale and Global Improvement and Satisfaction. Results Patients’ fatigue, physical functioning and social adjustment scores significantly improved over the duration of treatment with medium to large effect sizes (|d| = 0.45–0.91). Furthermore, 85% of patients self-reported that they felt an improvement in their fatigue at follow-up and 90% were satisfied with their treatment. None of the regression models convincingly predicted improvement in outcomes with the best model being (R2 = 0.137). Conclusions Patients’ fatigue, physical functioning and social adjustment all significantly improved following cognitive behavioural therapy for chronic fatigue syndrome in a naturalistic outpatient setting. These findings support the growing evidence from previous randomised control trials and suggest that cognitive behavioural therapy could be an effective treatment in routine treatment settings.
Distribution patterns of pathological venous reflux and risk factors in patients with skin changes due to primary venous disease in North India
Authors: Jain Prashant , Savlania Ajay , Behera Arunanshu , Gorsi Ujjwal 
Published: September 2020

Objectives To determine the distribution patterns of pathological venous reflux and risk factors in patients with skin changes due to primary venous disease. Methods Two hundred limbs belonging to C4, C5 & C6 classes were examined with duplex ultrasound to determine the sites of reflux. We also analyzed the correlation of risk factors with patterns and severity of disease. Results Among 200 limbs, superficial system reflux was found in 163 limbs (81.5%), deep system reflux in 10 limbs (5%) and perforator system reflux in 180 limbs (90%). The most common pattern of abnormality was combined superficial and perforator system reflux. Of all the risk factors, prolonged standing, obesity and in the female history of pregnancy preceding varicose occurrence had the highest prevalence. Conclusions In patients with primary chronic venous disease, lifestyle modification is required to avoid risk associated with obesity and prolonged standing. The higher prevalence of pathological perforator reflux in association with advanced venous disease necessitates careful treatment of this least reported pathology to achieve better treatment results.
Successful salvage via re-osseointegration of a loosened implant in a patient with transtibial amputation
Authors: Gstoettner Clemens , Salminger Stefan , Sturma Agnes , Moser Veith , Hausner Thomas , Brånemark Rickard , Aszmann Oskar C 
Published: September 2020

Case Description:
Osseointegration is a relatively new technique for prosthetic limb attachment that offers various improvements for patients with amputation and facilitates joint preservation. We present a case of implant loosening during rehabilitation in a patient with transtibial amputation that was successfully managed through a combination of measures, aiming to promote re-osseointegration of the implant.

Objectives:
Not much is known about structured management of adverse events after osseointegration. Septic or aseptic loosening is currently regarded as implant failure, prompting removal and possible re-implantation at a later stage. The objective of this case report was to evaluate the feasibility of salvaging a loosened implant.

Study Design:
Case report.

Treatment:
A novel treatment approach was employed to enable renewed osseointegration of the implant. First, the bone-implant interface was disrupted and renewed through axial rotation and distal repositioning of the implant. Afterwards, extracorporal shockwave therapy and antibiotic treatment were administered. Prosthetic rehabilitation was then started anew. Regular follow-up x-rays and clinical evaluations were conducted, including standardized outcome tests.

Outcomes:
These combined measures led to a successful re-osseointegration of the implant. In a 21-month follow-up, the patient regained a stable and secure gait pattern, using his prosthesis every day for 15 hours and scoring above average on standardized outcome measures.

Conclusion:
This represents the first report of implant salvage after failed primary osseointegration. As the associated risks of this novel treatment are very low, investigations are warranted to evaluate this approach on a larger scale.
A manikin study comparing the performance of the GlideScope®, the Airtraq® and the C-MAC® in endotracheal intubation using suction-assisted laryngoscopy airway decontamination techniques in a simulated massive haematemesis scenario by emergency doctors
Authors: Wong Ching Hin Kevin , Ko Shing , Wong Oi Fung , Ma Hing Man , Lit Chau Hung Albert , Shih Yau Ngai 
Published: September 2020

Background: The suction-assisted laryngoscopy and airway decontamination (SALAD) techniques (level 1, SALAD-1 and level 2, SALAD-2) are newly proposed airway management skills to facilitate endotracheal intubation in patients with massive haematemesis. A pilot study using GlideScope® demonstrated the superior performance of SALAD-1 technique in massive haematemesis simulation. Objectives: To compare the performance of three different video laryngoscopes (the GlideScope®, the Airtraq® and the C-MAC®) in endotracheal intubation using SALAD techniques by emergency doctors in a manikin simulating massive haematemesis. Methods: Forty-eight emergency doctors were recruited. The participants’ performance of endotracheal intubation using the GlideScope®, the Airtraq® and the C-MAC® with the conventional and the two SALAD techniques in a manikin simulating massive haematemesis was evaluated. The time for intubation, number of attempts, rate of failed intubation, amount of aspirated fluid and the subjective ease of different devices and techniques were compared. Results: The C-MAC® had shorter intubation time compared with GlideScope® when using conventional (mean intubation time: 28.48 vs 47.00 s, p = 0.018) and SALAD-1 technique (mean intubation time: 29.35 vs 43.25 s, p < 0.039). The intubation time of all three video laryngoscopes was similar in SALAD-2 technique. There was no significant difference in the number of attempts and failed intubation rate among different video laryngoscopes in using different techniques. Intubation with the C-MAC® resulted in the least mean amount of aspiration in all the conventional (35.63 mL), SALAD-1 (14.06 mL) and SALAD-2 (18.13 mL) techniques. However, the results were not significantly different from the GlideScope® and the Airtraq®. The C-MAC® was rated the most favourable video laryngoscope for the SALAD-1 technique (p < 0.001). There was no significant preference for different video laryngoscopes in using the SALAD-2 technique (p = 0.111). Conclusion: All the video laryngoscopes have similar intubation performance with the SALAD-1 and SALAD-2 techniques. The C-MAC® performed better than GlideScope® in terms of intubation time. The C-MAC® was the most favourable video laryngoscope for the SALAD-1 technique.
Development of Machine Learning Models to Validate a Medication Regimen Complexity Scoring Tool for Critically Ill Patients
Authors: Al-Mamun Mohammad A. , Brothers Todd , Newsome Andrea Sikora 
Published: September 2020

Introduction: The Medication Regimen Complexity -Intensive Care Unit (MRC-ICU) is the first tool for measuring medication regimen complexity in critically ill patients. This study tested machine learning (ML) models to investigate the relationship between medication regimen complexity and patient outcomes. Methods: This study was a single-center, retrospective observational evaluation of 130 adults admitted to the medical ICU. The MRC-ICU score was utilized to improve the inpatient model’s prediction accuracy. Three models were proposed: model I, demographic data without medication data; model II, demographic data and medication regimen complexity variables; and model III: demographic data and the MRC-ICU score. A total of 6 ML classifiers was developed: k-nearest neighbor (KNN), naïve Bayes (NB), random forest, support vector machine, neural network, and logistic classifier (LC). They were developed and tested using electronic health record data to predict inpatient mortality. Results: The results demonstrated that adding medication regimen complexity variables (model II) and the MRC-ICU score (model III) improved inpatient mortality prediction.. The LC outperformed the other classifiers (KNN and NB), with an overall accuracy of 83%, sensitivity (Se) of 87%, specificity of 67%, positive predictive value of 93%, and negative predictive value of 46%. The APACHE III score and the MRC-ICU score at the 24-hour interval were the 2 most important variables. Conclusion and Relevance: Inclusion of the MRC-ICU score improved the prediction of patient outcomes on the previously established APACHE III score. This novel, proof-of-concept methodology shows promise for future application of the MRC-ICU scoring tool for patient outcome predictions.
Association Between Device-Measured Moderate-to-Vigorous Physical Activity and Academic Performance in Adolescents
Authors: Bueno Maria Raquel de Oliveira , Zambrin Lidyane Ferreira , Panchoni Camila , Werneck André Oliveira , Fernandes Romulo Araújo , Serassuelo Hélio , Romanzini Marcelo , Ronque Enio Ricardo Vaz 
Published: September 2020

Background Although many studies found a positive association between physical activity (PA) and academic performance (AP), most did not consider important variables of school setting and students’ self-concept. Aims To analyze the association between moderate-to-vigorous PA (MVPA) and AP in adolescents, considering potential confounding variables of school setting and self-concept in adolescents. Method The final sample was composed of 394 students (186 boys) with a mean age of 11.3 ( SD = 0.8) years. The school grades were used as an indicator of AP. Measurements of body mass and stature were collected, and the body mass index was calculated and converted into z-score values. Maternal education, socioeconomic status, self-concept, and variables of the school setting were self-reported. MVPA and sedentary behavior (SB) were measured through accelerometry (GT3X and GT3X+; ActiGraph, Pensacola, Florida). Multiple linear regression was used for the association analyses, adopting p < .05. Results MVPA was inversely associated with global AP and mathematics only for girls: β = −.105 (95% CI [−0.205, −0.006]; p = .038); β = −.136 (95% CI [−0.261, −0.011]; p = .033). After adjusting for the school setting and self-concept, these significant associations disappear. Discussion MVPA was inversely associated with global AP and mathematics only for girls regardless of age, z-score body mass index, maternal education, socioeconomic status, and SB. However, after adjusting for school setting and self-concept, theses association disappear in mathematics and global AP, respectively. Conclusion The device-measured MVPA was not associated with AP after controlling for important variables (school setting and self-concept).
A mutation in CRX causing pigmented paravenous retinochoroidal atrophy
Authors: Oh Jin Kyun , Nuzbrokh Yan , Lee Winston , Lima de Carvalho Jose Ronaldo , Wang Nan Kai , Sparrow Janet R , Allikmets Rando , Tsang Stephen H 
Published: September 2020

Introduction: Mutations in the cone-rod homeobox ( CRX) gene, a known cause of inherited retinal dystrophy, are characterized by extensive phenotypic heterogeneity. We describe a novel presentation of rod-cone dystrophy (RCD) phenocopying pigmented paravenous retinochoroidal atrophy associated with a mutation in CRX. Case description: A 53-year-old man and his 48-year-old brother presented with a history of progressive vision loss and nyctalopia. Fundus examination revealed a bull’s eye lesion with chorioretinal atrophy and intraretinal pigment migration, while spectral-domain optical coherence tomography (SD-OCT) demonstrated retinal thinning with outer retinal atrophy. On short-wavelength autofluorescence (SW-AF) imaging, an atypical paravenous pattern of atrophy with a surrounding hyperautofluorescent border was observed. Full-field electroretinogram (ffERG) revealed a rod-cone pattern of dysfunction. A heterozygous pathogenic variant, c.119G>A:p.(Arg40Gln), in the CRX gene was identified in both brothers and segregated in their family. Conclusion: This case report broadens the currently known phenotypic presentations of CRX-associated retinopathy and suggests that mutations in CRX may be associated with pigmented paravenous retinochoroidal atrophy.
The application of intracavitary electrocardiogram for tip location of femoral vein catheters in chemotherapy patients with superior vena cava obstruction
Authors: Ma Mengdan , Zhang Jinghui , Hou Jianmei , Gong Zhihong , Hu Zixin , Chen Shujie , Kong Xiaoya , Shi Zhengkun 
Published: September 2020

Background: Most studies focused on the application of intracavitary electrocardiogram (IC-ECG) location in superior vena cava access catheterization, this study aimed to explore the effect of IC-ECG for tip location of femoral vein catheters in chemotherapy patients with superior vena cava obstruction (SVCO). Methods: A total of 158 patients placed catheters through superficial femoral vein from July 2016 to May 2019 were enrolled in the randomized controlled study. The patients were divided into two groups by envelope lottery method: X-ray location was used in the control group ( n = 79); IC-ECG location was used in the observation group ( n = 79). The catheters should be located at or near the inferior vena cava (IVC)-right atrium (RA) junction (above the level of diaphragm within the IVC). The general information of patients, clinical catheterization effects and catheter-related complications were compared between the groups. Results No significant differences in general information, catheter obstruction, catheter-related thrombosis, catheter exit-site bleeding and infection were found between the groups. The rate of successful insertion at the first attempt and patient satisfaction in the observation group were significantly higher than that in the control group ( p < 0.05). The time and cost of location and the incidence of catheter-related complications in the control group were 32.57 min and 140.51 Yuan and 21.5%, which were significantly higher than 6.94 min and 13.59 Yuan and 7.6% in the observation group ( p < 0.05). Conclusion IC-ECG accurately located the tip of femoral vein catheters, reduced the incidence of catheter-related complications and the time and cost of location, improved patient satisfaction.