bluuebunny/crossref_metadata_2025_split huggingface dataset:
mHealth and wearable technology should replace motor diaries to track motor fluctuations in Parkinson’s disease
Authors: Erb M. Kelley , Karlin Daniel R. , Ho Bryan K. , Thomas Kevin C. , Parisi Federico , Vergara-Diaz Gloria P. , Daneault Jean-Francois , Wacnik Paul W. , Zhang Hao , Kangarloo Tairmae , Demanuele Charmaine , Brooks Chris R. , Detheridge Craig N. , Shaafi Kabiri Nina , Bhangu Jaspreet S. , Bonato Paolo 
Published: January 2020

AbstractAccurately monitoring motor and non-motor symptoms as well as complications in people with Parkinson’s disease (PD) is a major challenge, both during clinical management and when conducting clinical trials investigating new treatments. A variety of strategies have been relied upon including questionnaires, motor diaries, and the serial administration of structured clinical exams like part III of the MDS-UPDRS. To evaluate the potential use of mobile and wearable technologies in clinical trials of new pharmacotherapies targeting PD symptoms, we carried out a project (project BlueSky) encompassing four clinical studies, in which 60 healthy volunteers (aged 23–69; 33 females) and 95 people with PD (aged 42–80; 37 females; years since diagnosis 1–24 years; Hoehn and Yahr 1–3) participated and were monitored in either a laboratory environment, a simulated apartment, or at home and in the community. In this paper, we investigated (i) the utility and reliability of self-reports for describing motor fluctuations; (ii) the agreement between participants and clinical raters on the presence of motor complications; (iii) the ability of video raters to accurately assess motor symptoms, and (iv) the dynamics of tremor, dyskinesia, and bradykinesia as they evolve over the medication cycle. Future papers will explore methods for estimating symptom severity based on sensor data. We found that 38% of participants who were asked to complete an electronic motor diary at home missed ~25% of total possible entries and otherwise made entries with an average delay of >4 h. During clinical evaluations by PD specialists, self-reports of dyskinesia were marked by ~35% false negatives and 15% false positives. Compared with live evaluation, the video evaluation of part III of the MDS-UPDRS significantly underestimated the subtle features of tremor and extremity bradykinesia, suggesting that these aspects of the disease may be underappreciated during remote assessments. On the other hand, live and video raters agreed on aspects of postural instability and gait. Our results highlight the significant opportunity for objective, high-resolution, continuous monitoring afforded by wearable technology to improve upon the monitoring of PD symptoms.
Fingerprints of a second order critical line in developing neural networks
Authors: Kanders Karlis , Lee Hyungsub , Hong Nari , Nam Yoonkey , Stoop Ruedi 
Published: January 2020

AbstractPatterns of biological activity with properties similar to critical states of statistical mechanics have received much attention, as they were mostly seen as indicators of computational optimality. Commonly, a single regime around an isolated critical point is expected. Our experimental data and our network simulations of developing neural cultures indicate the possibility of transitions between different critical regimes. In the latter, the addition of further fundamental neurophysiological principles to the standard neurodynamics branching model generates steeper power laws that have been observed in various experiments. Our analysis exhibits two populations of neurons, each composed of inhibitory and excitatory sites, that have distinct dynamical and topological properties. This generates a line of second order critical points, similar to what is known from the thermodynamics of two-component alloys. An analysis of two major critical regimes found in the experiments suggests that different critical regimes may express distinct computational roles.
Changes in mammalian copper homeostasis during microbial infection
Authors: Culbertson Edward M , Khan Aslam A , Muchenditsi Abigael , Lutsenko Svetlana , Sullivan David J , Petris Michael J , Cormack Brendan P , Culotta Valeria C 
Published: January 2020

Abstract
Animals carefully control homeostasis of Cu, a metal that is both potentially toxic and an essential nutrient. During infection, various shifts in Cu homeostasis can ensue. In mice infected with Candida albicans, serum Cu progressively rises and at late stages of infection, liver Cu rises, while kidney Cu declines. The basis for these changes in Cu homeostasis was poorly understood. We report here that the progressive rise in serum Cu is attributable to liver production of the multicopper oxidase ceruloplasmin (Cp). Through studies using Cp−/− mice, we find this elevated Cp helps recover serum Fe levels at late stages of infection, consistent with a role for Cp in loading transferrin with Fe. Cp also accounts for the elevation in liver Cu seen during infection, but not for the fluctuations in kidney Cu. The Cu exporting ATPase ATP7B is one candidate for kidney Cu control, but we find no change in the pattern of kidney Cu loss during infection of Atp7b−/− mice, implying alternative mechanisms. To test whether fungal infiltration of kidney tissue was required for kidney Cu loss, we explored other paradigms of infection. Infection with the intravascular malaria parasite Plasmodium berghei caused a rise in serum Cu and decrease in kidney Cu similar to that seen with C. albicans. Thus, dynamics in kidney Cu homeostasis appear to be a common feature among vastly different infection paradigms. The implications for such Cu homeostasis control in immunity are discussed.
RCAN1.4 mediates high glucose-induced matrix production by stimulating mitochondrial fission in mesangial cells
Authors: Chen Hong-Min , Dai Jia-Jia , Zhu Rui , Sang Xue-Yu , Peng Fang-Fang , Yu Hong , Zhang Bai-Fang 
Published: January 2020

Abstract
High glucose (HG)-induced mitochondrial dynamic changes and oxidative damage are closely related to the development and progression of diabetic kidney disease (DKD). Recent studies suggest that regulators of calcineurin 1 (RCAN1) is involved in the regulation of mitochondrial function in different cell types, so we investigate the role of RCAN1 in mitochondrial dynamics under HG ambience in rat glomerular mesangial cells (MCs). MCs subjected to HG exhibited an isoform-specific up-regulation of RCAN1.4 at both mRNA and protein levels. RCAN1.4 overexpression induced translocation of Dynamin related protein 1 (Drp1) to mitochondria, mitochondrial fragmentation and depolarization, accompanied by increased matrix production under normal glucose and HG ambience. In contrast, decreasing the expression of RCAN1.4 by siRNA inhibited HG-induced mitochondrial fragmentation and matrix protein up-regulation. Moreover, both mitochondrial fission inhibitor Mdivi-1 and Drp1 shRNA prevented RCAN1.4-induced fibronectin up-regulation, suggesting that RCAN1.4-induced matrix production is dependent on its modulation of mitochondrial fission. Although HG-induced RCAN1.4 up-regulation was achieved by activating calcineurin, RCAN1.4-mediated mitochondrial fragmentation and matrix production is independent of calcineurin activity. These results provide the first evidence for the HG-induced RCAN1.4 up-regulation involving increased mitochondrial fragmentation, leading to matrix protein up-regulation.
Efficacy and safety of Chinese patent medicine (Jinlong capsule) in the treatment of advanced hepatocellular carcinoma: a meta-analysis
Authors: Xu He , Wei Wenjie , Y. Mu , Dong Chengwei 
Published: January 2020

Abstract
Jinlong capsule (JLC), a type of herbal medicine, is considered to be a promising adjuvant therapy for hepatocellular carcinoma (HC). Although an analysis of the published literature has been performed, the exact effects and safety of JLC are yet to be systematically investigated. Therefore, a wide-ranging systematic search of electronic databases to draw conclusions was performed. Data from 29 trials, including 2488 patients with advanced HC, were analyzed. The results indicated that, compared with conventional treatment alone, the combination of conventional treatment and JLC markedly improved overall patient response (odds ratio (OR) 2.06 [95% confidence interval (CI) 1.71–2.49]; P&lt;0.00001), disease control rate (DCR) (OR 2.17 [95% CI 1.74–2.71]; P&lt;0.00001) and quality of life (QoL) (OR 2.71 [95% CI 2.05–3.58]; P&lt;0.00001), and significantly prolonged 6- (P=0.01), 12- (P&lt;0.00001), 24- (P=0.001) and 36-month (P&lt;0.0001) overall survival (OS) rates. The immune function of patients was also significantly enhanced after combined conventional therapy and JLC treatment, indicated by clearly increased percentages of CD3+ (P&lt;0.0001), CD4+ (P&lt;0.00001) and natural killer (NK) cells (P=0.0003), and CD4+/CD8+ ratio (P&lt;0.00001). The incidence of leukopenia (P&lt;0.00001), hepatotoxicity (P=0.005), and myelosuppression (P=0.0007) was lower in HC patients injected with JLC, whereas other adverse events did not differ significantly between the two groups (P&gt;0.05). In summary, results of this meta-analysis suggest that the combination of conventional treatment and JLC is more effective for the treatment of HC than conventional treatment alone.
Translation elongation factor 1A2 is encoded by one of four closely related eef1a genes and is dispensable for survival in zebrafish
Authors: Idigo Nwamaka J. , Soares Dinesh C. , Abbott Catherine M. 
Published: January 2020

Abstract
Zebrafish are valuable model organisms for the study of human single-gene disorders: they are genetically manipulable, their development is well understood, and mutant lines with measurable, disease-appropriate phenotypic abnormalities can be used for high throughput drug screening approaches. However, gene duplication events in zebrafish can result in redundancy of gene function, masking loss-of-function phenotypes and thus confounding this approach to disease modelling. Furthermore, recent studies have yielded contrasting results depending on whether specific genes are targeted using genome editing to make mutant lines, or whether morpholinos are used (morphants). De novo missense mutations in the human gene EEF1A2, encoding a tissue-specific translation elongation factor, cause severe neurodevelopmental disorders; there is a real need for a model system to study these disorders and we wanted to explore the possibility of a zebrafish model. We identified four eef1a genes and examined their developmental and tissue-specific expression patterns: eef1a1l1 is first to be expressed while eef1a2 is only detected later during development. We then determined the effects of introducing null mutations into translation elongation factor 1A2 (eEF1A2) in zebrafish using CRISPR/Cas9 gene editing, in order to compare the results with previously described morphants, and with severe neurodegenerative lethal phenotype of eEF1A2-null mice. In contrast with both earlier analyses in zebrafish using morpholinos and with the mouse eEF1A2-null mice, disruption of the eef1a2 gene in zebrafish is compatible with normal lifespan. The resulting lines, however, may provide a valuable platform for studying the effects of expression of mutant human eEF1A2 mRNA.
Understanding the atmospheric properties and chemical composition of the ultra-hot Jupiter HAT-P-7b
Authors: Molaverdikhani K. , Helling Ch. , Lew B. W. P. , MacDonald R. J. , Samra D. , Iro N. , Woitke P. , Parmentier V. 
Published: January 2020

Aims. The atmospheres of ultra-hot Jupiters (UHJs) are commonly considered to be at thermochemical equilibrium. We aim to provide disequilibrium chemistry maps for a global understanding of the chemistry in the atmosphere of HAT-P-7b and assess the importance of disequilibrium chemistry on UHJs.
Methods. We applied a hierarchical modeling approach using 97 1D atmospheric profiles from a 3D general circulation model of HAT-P-7b. For each atmospheric 1D profile, we evaluated our kinetic cloud formation model consistently with the local gas-phase composition in chemical equilibrium. This served as input to study the quenching of dominating CHNO-binding molecules. We evaluated quenching results from a zeroth-order approximation in comparison to a kinetic gas-phase approach.
Results. We find that the zeroth-order approach of estimating quenching points agrees well with the full gas-kinetic modeling results. However, it underestimates the quenching levels by about one order of magnitude at high temperatures. Chemical disequilibrium has the greatest effect on the nightside and morning abundance of species such as H, H2O, CH4, CO2, HCN, and all CnHm molecules; heavier CnHm molecules are more affected by disequilibrium processes. The CO abundance, however, is affected only marginally. While dayside abundances also notably change, those around the evening terminator of HAT-P-7b are the least affected by disequilibrium processes. The latter finding may partially explain the consistency of observed transmission spectra of UHJs with atmospheres in thermochemical equilibrium. Photochemistry only negligibly affects molecular abundances and quenching levels.
Conclusions. In general, the quenching points of the atmosphere of HAT-P-7b are at much lower pressures than in the cooler hot-jupiters. We propose several avenues to determining the effect of disequilibrium processes on UHJs that are in general based on abundance and opacity measurements at different local times. It remains a challenge to completely disentangle this from the chemical effects of clouds and that of a primordial nonsolar abundance.
Beurteilung und Nutzung der 2016 reformierten Psychotherapierichtlinie
Authors: Bangeow Petjo , Rapp Michael A. 
Published: January 2020

Zusammenfassung
Ziel der Studie Dieser Artikel untersucht, inwiefern Aspekte der 2016 reformierten Psychotherapierichtlinie aus Sicht der drei Richtlinienverfahren für die praktische Arbeit unterschiedlich bewertet und genutzt werden.
Methodik Eine Onlineumfrage wurde unter vertragsärztlich tätigen PsychotherapeutInnen (n = 987) durchgeführt. Die Fragen bezogen sich auf die unterschiedlichen Neuerungen in der Psychotherapierichtlinie.
Ergebnisse Signifikante Unterschiede wurden u. a. in der Nutzung der erweiterten Befugnisse sowie in der Abrechnung bestimmter Leistungen deutlich. Die Gruppen unterschieden sich auch in der Beantragung von Behandlungskontingenten.
Schlussfolgerung Es scheint sinnvoll, Elemente der Richtlinienreform aus der Sicht des bevorzugten Behandlungsverfahrens zu evaluieren. Jene Aspekte scheinen bedeutsam, die sich auf die unmittelbare Arbeit mit den PatientInnen beziehen.
Wer nimmt sich das Leben? Ergebnisse einer psychologischen Autopsiestudie im Allgäu basierend auf Polizeiakten
Authors: Brieger Peter , Kaps Beatrix , Lohmann Frank , Kammerlander Beatrix , Hamann Johannes 
Published: January 2020

Zusammenfassung
Ziel der Studie Erhebung von Suizidmotiven, Risikofaktoren und Ansatzpunkten für Prävention.
Methodik Psychologische Autopsiestudie basierend auf Akten der Kriminalpolizei Kempten 2001 bis 2009.
Ergebnisse Die meisten der 626 Suizidenten zeigten bekannte Risikofaktoren für Suizide. Häufig waren negative Lebensereignisse im Vorfeld und Ankündigungen des Suizids.
Schlussfolgerung Die Suizide sind Ergebnis eines Zusammenspiels psychopathologischer und psychosozialer Faktoren. Suizidprävention muss auf die bessere Erkennung von Suizidankündigungen zielen und klare Konzepte der spezifischen Krisenversorgung vorhalten.
Simultaneous Bilateral Total Knee Arthroplasty Becomes Safer after Institution of Optimal Perioperative Management: A Longitudinal Cohort Study
Authors: Chen Shih-Hao , Chen Jen-Yuh , Wong Tze-Hong , Buechel Frederick , Wu Meng-Huang 
Published: January 2020

AbstractSimultaneous bilateral total knee arthroplasty (SBTKA) increases the rates of procedure-related complications and mortality compared with unilateral TKA. There are no well-defined guidelines for selecting patients to avoid mortality and proposing an upgrade treatment to decrease complication rates. This study aimed to evaluate whether optimal perioperative management could improve the safety of SBTKA. From 2005 to 2017, 1,166 cases of SBTKA were identified from 14,209 TKA procedures. We retrospectively examined the SBTKA patients' demographics, comorbidity profiles, procedure-related complications, and perioperative management during two time periods. Optimal perioperative workup for managing SBTKA significantly decreased the incidences of major complication from 6.2 to 2.4% (p = 0.001) and minor complications from 28.9 to 21.5% (p = 0.004) during period I and period II, respectively. The efficiency of less tourniquet use along with intraarticular tranexamic acid injection was demonstrated by the decreases of hemoglobin (Hb) change in the first 2 days after surgery (p = 0.005) and blood transfusion requirement (p = 0.035) during the SBTKA. Furthermore, the less tourniquet use group had less thigh pain (visual analog scale decreased from 6.0 to 4.2, p = 0.003), shorter duration of hospital stay (decreased from 7.8 to 7.1, p < 0.001), and lower coagulation time (decrease from 3.5 to 2.9, p < 0.001) than the routine tourniquet use group. Patient's screening must be performed carefully for cardiopulmonary compromise in patients aged >80 years and with an American Society of Anesthesiologists score of 3. Additionally, hospitalists should consider developing methods for the eligibility, testing, and perioperative monitoring of patients who undergo SBTKA with the aim of avoiding complications and improving outcomes.
Rhythmic variability in Spanish/English bilinguals in
California
Authors: Robles-Puente Sergio 
Published: January 2020

Abstract
In this study two techniques were used to analyze the linguistic
rhythm of Mexican Spanish/English bilinguals in Los Angeles (California):
(i)-nPVI, consisting of measurements of durations of successive pairs of vowels,
and (ii)-voicing ratios, consisting of a function that calculates the voiced and
voiceless portions of the signal. The speech of forty-nine participants in five
groups was examined: (G1)-twelve native speakers of English, (G2)-eight Mexican
Sp/Eng adult bilinguals who have been in L.A. since childhood, (G3)-eleven
Mexican Sp/Eng young bilinguals descendants of immigrants and born in L.A.,
(G4)-seven Mexican Sp/Eng adult bilinguals who moved to L.A. as adults and
(G5)-eleven native speakers of Spanish who have stayed in L.A. for a short
period of time. Both methodologies indicate that G1 and G2 show English-like
rhythm in both languages while G4 and G5 present Spanish-like rhythm. G3
accommodates rhythm depending on the language. Results reveal how rhythm can
suffer attrition and transfer processes depending on the age or length of
exposure to the L2. The study also highlights the unique linguistic situation of
Los Angeles where members of the Mexican community have different levels of
exposure to the Spanish and English languages.
Franz Kern
Authors: Osborne Timothy 
Published: January 2020

An examination of Franz Kern’s main works (1883a, 1883b, 1884, 1886, 1888) quickly reveals that his concept of
sentence structure is closely similar to many modern analyses in the
tradition of dependency grammar (DG). Kern took the finite
verb as the sentence root and positioned the subject and object phrases as
equi-level dependents of the verb in a like manner. In so doing, he was
rejecting the binary subject-predicate division associated with the works of
some of his contemporaries, most notably, Reed and Kellogg (1876). The aspect of Kern’s understanding of
sentence structure that is particularly valuable in tracing the development
of dependency syntax was his use of sentence diagrams. Kern produced
numerous diagrams that are similar to the stemmas Tesnière used
approximately 60 years later. Thus, Kern’s works on sentence structure stand
as a particularly clear manifestation of dependency syntax long before
dependency grammar became associated primarily with Tesnière’s efforts
(1953, 1959). Interestingly, Tesnière did not cite Kern.
This situation raises a basic question about whether Tesnière knew about
Kern’s works at all, or whether he was indirectly influenced by Kern through
the ideas of other German grammarians following in a tradition that Kern had
helped establish many decades earlier.
Negotiating the intersections between dark tourism and pilgrimage.
Authors: Korstanje M. E. , Olsen D. H. 
Published: January 2020

Abstract

This chapter discusses some of the interconnections between dark tourism and pilgrimage/religious travel within the following four themes: (1) dark tourism and pilgrimage as heritage; (2) dark tourism and pilgrimage as a mechanism of resilience; (3) dark tourism and pilgrimage as a mediator between the self and death; and (4) critical approaches to dark tourism and pilgrimage.
Im(possible) dark tourism in Bulgaria.
Authors: Mileva S. 
Published: January 2020

Abstract

This chapter explores the (im)possibility of developing dark tourism as a tourism niche market in Bulgaria. In particular, it looks at the complex political and historical development of the country and focuses on the sensitive nature of death and Bulgaria's dark history as it relates to the approach of the Bulgarian Orthodox Church to death and sites of death; the role of communism in the formation of Bulgarian identity; and how Bulgarians today handle their 'difficult heritage' from the socialist/communist period.
Martyrdom and dark tourism in Carthage, Illinois.
Authors: Esplin S. C. , Olsen D. H. 
Published: January 2020

Abstract

This chapter examines how Carthage Jail, the martyrdom site of Joseph Smith, founder of the Church of Jesus Christ of Latter-day Saints, has evolved from a site of tragedy to a site of healing and religious co-operation. As a case study in dark tourism formation, this chapter examines how the Church has transformed the jail, the scene of the faith's greatest suffering, into a pilgrimage destination focusing on triumph rather than tragedy.
Designing experiences at holocaust memorial sites.
Authors: Ward P. , Hill B. 
Published: January 2020

Abstract

After situating Holocaust tourism in the context of dark tourism, principles of experience design are explained and discussed, including the progression of economic value, the Four Realms of Experience, and THEME. Examples are given from specific Holocaust tourism sites to further illustrate how the principles are used in practice, and suggestions for improving the dark Holocaust tourism experience are also discussed.
Bilateral key comparison of INMETRO and INTI humidity standards in the dew/frost-point temperature range from -30 °C to +60 °C (SIM.T-K6.7)
Authors: Brionizio Julio D , Skabar Javier G 
Published: January 2020

The aim of this paper is to describe a bilateral comparison carried out by the hygrometry laboratories of the National Metrological Institutes of Brazil and Argentina, INMETRO and INTI, respectively. The comparison, registered as a bilateral key comparison of the Inter American Metrology System (SIM) as SIM.T-K6.7 - INMETRO/INTI, was performed in the range from -30 °C to 60 °C of dew/frost-point temperatures. This paper presents the facilities of the laboratories, the measurement procedures, the uncertainty analysis, the compatibility of the measurement results (by means of the normalised error and by the degree of equivalence) and the degree of equivalence for the dew-point temperatures 1 °C and 20 °C between INTI and the CCT-K6 key comparison reference value by means of a previous comparison between INMETRO and the National Institute of Standards and Technology (NIST).

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCT, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).