bluuebunny/crossref_metadata_2025_split huggingface dataset:
A heuristic model for collaborative practice – Part 2: An elaboration of theoretical perspectives and strategies in community mental health and substance abuse care
Authors: Sundet Rolf , Kim Hesook Suzie , Karlsson Bengt , Borg Marit , Sælør Knut Tore , Ness Ottar 
Published: May 2020

Abstract
Background Various models for collaborative practice in mental health care incorporating the perspectives of service-user participation and collaboration in the care have been developed. However, the emphasis in these practice models has not been on identifying specific features of “how” collaboration and service-user participation can occur and be nurtured. This suggests a need for a collaborative practice model that specifies essential strategies operationalizing the tenets of service-user participation and collaboration applicable in mental health and substance abuse (MHSA) care. Methods A double helix approach of coalescing theoretical ideas and empirical findings to develop a practice model that is applicable in MHSA practice. A theoretical analysis is carried out to identify the critical, foundational elements for collaborative practice in MHSA practice, and has identified the philosophical-theoretical orientations of Habermas’ theory of communicative action, Bakhtin’s dialogicality, and the philosophy of personhood as the foundational features of collaboration. This base is juxtaposed with the results of a qualitative meta-analysis of 18 empirical articles on collaboration in MHSA to advance a collaborative practice model specifically in the domain of service user/professional collaboration. Results “The collaborative, dialogue-based clinical practice model” (CDCP Model) for community mental health care is proposed, within the structure of four main components. The first specifies the framework for practice that includes person-centered care, recovery-orientation, and a pluralistic orientation and the second identifies the domains of collaboration as service user/professional collaboration, inter-professional collaboration, and service sector collaboration. The third identifies self-understanding, mutual understanding, and shared decision-making as the essential principles of collaboration. The fourth specifies interactive-dialogic processes, negotiated-participatory engagement processes, and negotiated-supportive processes as the essential strategies of collaboration applicable in service user/professional collaboration which were extracted in the empirical work. An illustration of the CDCP Model in a clinical case is given.Conclusions The CDCP Model presented fills the gap that exists in the field of community MHSA practice regarding how to operationalize systematically the tenets of person-centeredness, recovery-oriented, and pluralism-oriented practice in terms of user/professional collaboration.
Machine Learning model to predict the number of cases contaminated by COVID-19.
Authors: Erraissi Allae , Azouazi Mohamed , Belangour Abdessamad , Banane Mouad 
Published: May 2020

Abstract
Introduction:
This paper presents a dedicated machine learning model to predict the number of cases infected by the Corona Virus; the case of Morocco was chosen to validate this study.
Case description:
Completely realized in Spark ML with the 'Scala' language and tested for a certain number of algorithms generated on datasets coming from dedicated sources to gather Covid19 data in the world.
Discussion and Evaluation:
The results show the possibility of achieving better scores prediction after using the proposed method. We tested our model on the case of China and the results were relevant.
Conclusion
The proposed Machine Learning model can be applied to data from any country in the world. We have applied it in this paper to the case of Morocco and China. We are sending this work to the world to help them fight this 2019 Corona Virus pandemic.
Ephedra alata extracts exhibits anti-obesity, anti-hyperlipidaemic, anti-hyperglycemia, anti-antipyretic and analgesic effects through the inhibition of lipase, α-amylase and inflammation
Authors: Tiss Mohamed , Souiy Zoubeida , Boujbiha Mohamed , Achour Lotfi , Hamden Khaled 
Published: May 2020

Abstract
In this present study, phytochemical screening, anti-obesity, anti- antipyretic and analgesic effect of Ephedra alata (EA) extracts were evaluated. Results of this study showed that the methanol EA extract (MEAE) had a stronger inhibition activity on key enzyme related to obesity as lipase (IC50 = 1.296 mg/ml) as compared to water and ethyl acetate extracts ( with IC50 = 1.639 and 1.897 respectively). Also results revealed that ethyl acetate extract depicted high activity toward key enzyme related to hyperglycemia as α-amylase (IC50 = 0.284 mg/mL) while water and methanol extracts showed good to moderate inhibitory activity (IC50 = 1,525 and 1,103 mg/ml respectively). In HFFD rats, the administration of MEAE at 200 mg/kg inhibited key enzyme related to fat digestion and absorption as lipase in the intestine, pancreas and serum by 53, 40 and 53% respectively,which leads to decrease in body weight by 20% and also modulation of lipid profile. In addition, the administration of MEAE to HFFD-rats exerts an inhibitory effect on α-amylase activity in the intestine, pancreas and serum by 43, 26 and 46% respectively and this leads to decrease in blood glucose level by 35%. Also, MEAE exert antipyretic and analgesic activities. This study demonstrates for the first time that MEAE are efficient in preventing obesity and hyperglycemia and liver toxicity. This data generated during study shows antipyretic and analgesic activities of MEAE.
Improvements in French Risk Stratification Score were Correlated with Reductions in Mean Pulmonary Artery Pressure in Pulmonary Arterial Hypertension: A Subanalysis of the Japan Pulmonary Hypertension Registry (JAPHR)
Authors: Tamura Yuichi , Kumamaru Hiraku , Abe Kohtaro , Satoh Toru , Miyata Hiroaki , Ogawa Aiko , Tanabe Nobuhiro , Hatano Masaru , Yao Atsushi , Tsujino Ichizo , Fukuda Keiichi , Kimura Hiroshi , Kuwana Masataka , Matsubara Hiromi , Tatsumi Koichiro 
Published: May 2020

Abstract
Background Since there was no previous report, we analyzed the relationship between French Risk Stratification parameters in pulmonary arterial hypertension (PAH) and mean pulmonary arterial pressures (mPAP) using Japan PH Registry (JAPHR) national-wide cohort.Methods We enrolled 108 patients with PAH from JAPHR from previous reported cohort and analyzed the relations between French Risk Stratification scores and hemodynamic improvements.Results The ratio meeting 0 to 4 French Risk Stratification score was 21.3%, 31.5%, 32.4%, 13.0%, and 1.9% at baseline, and 6.5%, 23.2%, 33.3%, 23.2%, 13.9% at follow-up, respectively. The improvements in the number of criteria met were associated both with mPAP at follow-up (p = 0.03) and with the improvements in mPAP (p < 0.001).Conclusion The improvements in French Risk Stratification may become a marker of improved hemodynamics including mPAP.
Prediction and identification of immune genes related to the prognosis of patients with colon adenocarcinoma and its mechanisms
Authors: Chen Sihan , GD Cao , wei Wu , Yida Lu , Xiaobo He , Lei Yang , Ke Chen , Chen Bo , Xiong MaoMing 
Published: May 2020

Abstract
Background
Colon adenocarcinoma(COAD) is a type of gastrointestinal tumor with a high degree of malignancy, and its immunotherapy method has been stagnant. Recently, with the development of network databases and the development of bioinformatics tools, we can analyze the data in the current database to find out which genes may be the target of immunotherapy for COAD.
Methods
We use various codes and packages in R language to analyze the downloaded data, construct a riskScore model of immune genes and clinical data, and use Cox regression analysis to explore the clinical relationship between riskScore and COAD.
Results
We found that seven immune genes associated with the survival prognosis of COAD were related to the construction of a riskScore model. And Cox regression analysis found that there was clinical significance and statistical significance between the riskScore model and clinical data of COAD. Some traditional immune microenvironment cells also increase their cell content with the increase of riskScore.
Conclusions
We found 7 immune genes (SLC10A2, CXCL3, IGHV5-51, INHBA, STC1, UCN, and OXTR) that affect the clinical prognosis of COAD patients and can construct a riskScore model. It may be a target for future COAD immunotherapy.
Clinical efficacy of intersphincteric resection for low rectal cancer compared with abdominoperineal resection: a single-center retrospective study
Authors: Peng Baifu , Wu Zixin , He Zijian , Li Guanwei , Cao Jie , Li Wanglin 
Published: May 2020

Abstract
Purpose

In recent years, intersphincteric resection (ISR) has been increasingly used to replace abdominoperineal resection (APR) for low rectal cancer. This study was to compare the clinical efficacy of ISR and APR.
Methods

Between 2012 and 2018, 74 consecutive patients with low rectal cancer underwent ISR and APR in our medical centre. The outcomes were retrospectively studied and compared.
Results

A total of 43 patients underwent ISR and 31 underwent APR were included in the study. No significant differences were found between two groups in gender, age, BMI and ASA score. ISR group showed shorter operative time (P = 0.02) and less blood loss (P = 0.001). Hospital stays, time to soft diet, and postoperative thirty-day complications were not significantly different between the two groups. As for the long-term outcomes, the survival and recurrence rate were similar between two groups. Moreover, LARS score and Wexner score showed the anal function after ISR was generally satisfactory.
Conclusion

This study suggested that ISR may provide a feasible alternative to APR, with superior short-term outcomes, similar oncological outcomes and satisfactory postoperative anal function.
An outbreak of intestinal schistosomiasis in primary school children living along the shoreline of Lake Malawi, Mangochi District, Malawi
Authors: Kayuni Sekeleghe , O’Ferrall Angus M. , Baxter Hamish , Hesketh Josie , Mainga Bright , Lally David , Al-Harbi Mohammad H. , LaCourse E. James , Juziwelo Lazarus , Musaya Janelisa , Makaula Peter , Stothard John Russell 
Published: May 2020

Abstract
Background: Intestinal schistosomiasis was not considered endemic in Lake Malawi until November 2017 when populations of Biomphalaria pfeifferi were first reported; in May 2018, emergence of intestinal schistosomiasis was confirmed subsequently. This emergence was in spite of ongoing urogenital schistosomiasis control by preventive chemotherapy. In our current investigation, we ascertain if intestinal schistosomiasis is transitioning from emergence to outbreak, to judge whether stepped-up control interventions are needed.Methods: During May 2019, three cross-sectional surveys of primary school children for schistosomiasis were conducted using a combination of rapid diagnostic tests, parasitological examinations and applied morbidity-markers; 1) schistosomiasis dynamics were assessed at Samama (n=80) and Mchoka (n=80) schools, where Schistosoma mansoni was first reported, 2) occurrence of S. mansoni was investigated at two non-sampled schools, MOET (Mangochi Orphan Education and Training) (n=60) and Koche (n=60) schools, where B. pfeifferi was nearby, and 3) rapid mapping of schistosomiasis, and B. pfeifferi, conducted across a further 8 shoreline schools (n=240). Results: In total, 520 children from 12 lakeshore primary schools were examined, mean prevalence of S. mansoni by urine CCA-dipsticks was 31.5% [95% CI 27.5 – 35.5], with clear associations with faecal occult blood and ova-patent intestinal schistosomiasis. Infection prevalence significantly increased at Samama (RR=1.7 [95% CI 1.4 – 2.2]) and Mchoka (RR= 2.7 [95% CI 1.7 – 4.3]) schools, was confirmed at MOET (18.3%) and Koche (35.0%) schools, and across rapid mapping schools ranged from 10.0% to 56.7%. Several populations of B. pfeifferi were confirmed, with two new locations on the eastern shoreline encountered. Mean prevalence of urogenital schistosomiasis was 24.0% [95% CI 20.3 – 27.7]. Conclusions: When taken as a whole, we notify that intestinal schistosomiasis, once considered non-endemic in Lake Malawi, is now transitioning from emergence to outbreak. We recommend stepped-up preventive chemotherapy, with increased community-access to treatments, alongside renewed efforts in appropriate environmental control.
Electroacupuncture ameliorates motor dysfunction via inhibiting p66Shc-mediated oxidative stress and endoplasmic reticulum stress in rats with spinal cord injury
Authors: Zhao Fusheng , Wu Geng , Wu Yang , Bai Yunlong , Qiu Yongjia , Lei Wen , Guan Yanzhong 
Published: May 2020

Abstract
Background: Spinal cord injury (SCI) is a severe neurological disorder for which there is currently no effective treatment. Electroacupuncture (EA) is a means of combining traditional acupuncture with modern electrotherapy, which has been widely used and verified to have neuroprotective effects. The aim of this study was to evaluate the effects of EA treatment on the repair of SCI and to investigate the possible mechanisms. Methods: Rats were randomly divided into sham, sham+EA, SCI and SCI+EA four groups after SCI model was established. Rat motor function was assessed by the Basso, Beattie and Bresnahan locomotor rating scale, inclined plane test and footprint analysis. Histological alterations were examined with hematoxylin-eosin and Nissl staining. Oxidative stress was evaluated by measuring reactive oxygen species (ROS), glutathione (GSH), total antioxidant capacity (T-AOC), 3-nitrotyrosine (3-NT), as well as 4-hydroxynonenal (4-HNE) levels. The expression of p66Shc and endoplasmic reticulum stress (ERS) were detected to explore the involved mechanisms.Results: EA treatment significantly improved motor functional recovery, reduced spinal cord lesion cavity and neuronal chromatolysis after SCI. Meanwhile, EA treatment alleviated oxidative stress, as indicated by suppression of ROS production, increase in GSH and T-AOC levels and reduction of 3-NT and 4-HNE expression. Further, EA stimulation markedly eliminated the aberrant increase of p66Shc due to SCI in rats. More notably, EA treatment also attenuated ERS via down-regulation of glucose-regulated protein 78, activating transcription factor 4, C/EBP homologous protein, X-box binding protein 1 and activating transcription factor 6 expression in rat spinal cord tissues after SCI. Conclusions: These findings suggest that EA is a potential strategy for treatment of SCI, and the mechanism might be, at least in part, associated with mitigation of p66Shc-mediated oxidative stress and ERS in rats.
The effect of ophthalmic surgery on quality of life, depression, and anxiety disorders in visually impaired adults, National Eye Center, Kaduna, Nigeria.
Authors: Babalola Obafemi , Alhassan Mahmoud B , Nuhu Folorunsho T. 
Published: May 2020

Abstract
Introduction: Visual impairment caused severe disability in 2.2 billion people globally in 2010. This disability, which interacts with the physical, social, or attitudinal environment, spans across the lifecycle, and is associated with psychological distress and poor quality of life. This study aimed at describing the effect of surgery on blindness, QoL, anxiety and depressive disorders.Methods A one arm pre – post study was conducted among systematically-selected visually impaired adults (> 18 years) requiring surgery at the National Eye Centre (NEC), Nigeria. Trained research assistants used a pre-tested semi-structured questionnaire to interview participants at pre – and 10–12 week’s post-surgery. The visual function was measured with presenting visual acuity. Presence of psychological distress was defined by a scores ≥ 8 on the Hospital Anxiety and Depression scale (HADs), and confirmed the presence of anxiety, and depression using Mini International Neuropsychiatric Interview (MINI) questionnaire. The World Health Organization Quality of Life-Bref questionnaire was used to assess the quality of life. Descriptive analysis for frequency and proportions was carried out while Chi square McNemar test used to detect the effect of surgery on blindness, anxiety, depression and QoL. Statistically significant was set at p Value < 0.05.Results Of the 180 respondents, males accounted for 56.7%, and 72.2% had Cataract. Pre-surgical psychological distress, anxiety and depression were 38.9%, 25.6%, and 30.0%, respectively. Pre-surgery, a third had poor QoL on social relationship domain of WHOQoL-Bref. Ophthalmic surgery significantly improved blindness, anxiety, and social relationship QoL. No significant effect on depression.Conclusions Ophthalmic surgery influences social relationships QoL, and anxiety. It however has no effect on depression. Apart from surgical interventions, holistic care of vision impairment should involve mental care to improve QoL.
Is Erythropoietin Combining with Therapeutic Hypothermia an Efficient and Safe Therapy in Neonatal Hypoxic Ischemic Encephalopathy: A Prospective and Randomized Clinical Trial
Authors: Zou Liang-yan , Huang Bing-xue , Zhang Peng , Cheng Guo-qiang , Lu Chun-mei , Sun Jin-qiao , Zhou Wen-hao , Wang Lai-shuan 
Published: May 2020

Abstract
BackgroundTo evaluate the efficacy and safety of erythropoietin (Epo) combined with therapeutic hypothermia (TH) in neonatal hypoxic-ischemic encephalopathy (HIE).MethodsA total of 78 term infants with HIE were assigned randomly to receive Epo (n = 40) or placebo (n = 38). All infants received TH. Blood samples before TH, after TH and after Epo/placebo were collected for measuring TH associated adverse events, Epo associated factors and potential neural biomarkers. Basal ganglia/ watershed (BG/W) scoring system was used to assess brain injury in MRI. Neurodevelopmental evaluations were performed at 18 months by using BayleyScales of Infant Development II (Bayley II).ResultsEpo-treated group tend to have lower serum creatine kinase (CK) concentration (114 vs 202, P = .04) and higher serum K+, Mg2+ concentration (5.0 vs 4.5, P = .03; 1.0 vs 0.9, P = .02) than control group after intervention. Brain MRI was performed in 65 (83%) neonatal. Totally brain injury score was in even distribution between two groups (median, 0 vs 0, P = .61), but injury region in cortex plus basal nuclei comparing with in basal nuclei solely was less common in the Epo than in the control group (21% vs 31%, P = .046). Only forty patients (40/78, 51%) succeeded in achieving 18-month follow up data. The totally adverse outcomes were trend to decline in the Epo group (35% vs 60%, P = .21). No adverse events were ascribed to Epo treatment.ConclusionsThe combination of Epo and TH is proved to be feasible, safe and potential effective.Trial registration: ChiCTR-TRC-14004532, date of registration: April 18th, 2014.
Prognostic Values and Prospective Pathway Signaling of miR-30a in Ovarian Cancer: A Study Based on Gene Expression Omnibus and Bioinformatics Analysis
Authors: Lu Weijia , Wu Yunyu , Lu CanXiong , Zhu Ting , Ren ZhongLu , Yu Zhiwu 
Published: May 2020

Abstract
Objective

MicroRNAs (MiRNAs) is considered to play an important role in the occurrence and development of ovarian cancer(OC). Although miRNAs has been widely recognized in ovarian cancer, the role of hsa-miR-30a-5p (miR-30a) in OC has not been fully elucidated.
Methods

Through the analysis of public data sets in Gene Expression Omnibus (GEO) database and literature review, the significance of miR-30a expression in OC is evaluated. Three mRNA datasets of OC and normal ovarian tissue, GSE14407, GSE18520 and GSE36668, were downloaded from GEO to find the differentially expressed gene (DEG). Then the target genes of hsa-miR-30a-5p were predicted by miRWALK3.0 and TargetScan. Then, the gene overlap between DEG and the predicted target genes of miR-30a in OC was analyzed by Gene Ontology (GO) enrichment analysis. Protein-protein interaction (PPI) network was constructed by STRING and Cytoscape, and the effect of HUB gene on the prognosis of OC was analyzed.
Results

A common pattern of up-regulation of miR-30a in OC was found. A total of 225 DEG, were identified, both OC-related and miR-30a-related. Many DEG are enriched in the interactions of intracellular matrix tissue, ion binding and biological process regulation. Among the 10 major Hub genes analyzed by PPI, five Hub genes were significantly related to the overall poor survival of OC patients, in which the low expression of ESR1 ,MAPK10, Tp53 and the high expression of YKT ,NSF were related to poor prognosis of OC.
SCA7 mice recapitulate CNS, PNS and retina pathologies and show a transcriptional signature of Purkinje cell dysfunction prevailing in SCA1 and SCA2 mice.
Authors: NIEWIADOMSKA-CIMICKA Anna , Doussau Frédéric , Perot Jean-Baptiste , Roux Michel J , Keime Céline , Hache Antoine , Piguet Françoise , Novati Ariana , Weber Chantal , Yalcin Binnaz , Meziane Hamid , Champy Marie-France , Grandgirard Erwan , Karam Alice , Messaddeq Nadia , Eisenmann Aurélie , Brouillet Emmanuel , Nguyen Hoa Huu Phuc , Flament Julien , Isope Philippe , Trottier Yvon 
Published: May 2020

Abstract
Background

Background: Spinocerebellar ataxia type 7 (SCA7) is primarily characterized by progressive cerebellar degeneration with major alteration of Purkinje cells (PC) due to polyglutamine expansion in ATXN7, a subunit of SAGA transcriptional co-regulator complex. Additional neural tissues are affected and contribute to diverse symptoms. Current animal models were insufficient to recapitulate the broad spectrum of SCA7 pathology and the mechanisms of PC degeneration remain poorly explored.

Methods:

To delineate spatio-temporal features of SCA7, we performed a longitudinal characterization of a new knock-in mice line expressing ATXN7 with 140 glutamines (SCA7 140Q/5Q ) using a battery of analyses including motor tests, brain and retina imaging, morphometry, electrophysiology, electron microscopy and immunohistochemistry of disease tissues. We also determined the cerebellar transcriptome and cell-type specific gene deregulation.

Results:

Here we describe the first SCA7 knock-in mice that combine most cardinal features of SCA7, including retinal, cerebellar, cerebral and peripheral nerves pathologies, which account for progressive impairment of behavior, motor and vision functions. MRI and brain morphometry reveal atrophy of grey and white matter of specific cerebral regions, while peripheral nerves and photoreceptors show functional and morphological alterations. We show that cerebellar pathology is characterized by gene deregulation in all cerebellar cell types and alterations of SAGA-dependent epigenetic marks. Intranuclear accumulation of mutant ATXN7 and gene downregulation precede the onset of PC pacemaker dysfunction. Interestingly, PC show loss of expression of 83 PC-specific genes coding for ion channels, receptors and signaling proteins involved in pacemaker function and long-term depression, which are causal factors of many type of ataxias. Comparison of cerebellar transcriptome with other SCAs reveals a subset of 67 PC-specific genes downregulated in SCA1, SCA2 and SCA7, providing a common signature of early PC dysfunction.

Conclusions: The SCA7 140Q/5Q mice represent a promising model for the investigation of different aspects of SCA7 pathogenesis, and offers opportunities for translational development of therapeutic strategies by targeting the brain, retina, peripheral nerve or whole body. Our results also provide insight into converging mechanisms of PC degeneration in polyglutamine SCAs and point out molecular targets for therapeutic development w hich may prove beneficial for several SCAs.