bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of an interactive shirt for self-directed motor learning
Authors: Kim Eung Tae , Kim Sungmin 
Published: January 2020

PurposeThe purpose of this paper is to develop a framework for an interactive clothing that offers a self-directed learning environment in which learners can practice exercises in a time and cost-efficient manner.Design/methodology/approachTo verify the validity of the framework, an interactive shirt has been developed that can help its wearer practicing certain motor skills in a self-directed manner. This shirt enables the wearer to set reference body postures and to compare current posture with them and can notify whether its wearer repeats them correctly or not through vibrotactile feedback.FindingsThe interactive shirt prototype developed in this study will offer an environment in which learners can practice exercises in a time and cost-efficient manner.Originality/valueThe smart garment framework developed in this study consists of sensor-actuator module, switch device and control software. As this framework is easily scalable, it is expected that it can be used for various smart garment projects where an interaction between the garment and its wearer is needed.
Antibacterial potential of Nidus vespae built by invasive alien hornet, Vespa velutina nigrithorax, against food‐borne pathogenic bacteria
Authors: Kim Jaewon , Kim Minyoul , Lee Mijeong , Lee Yeon‐Jung , Kim Hak‐Ryul , Nam Ju‐Ock , Choi Moon Bo , Hahn Dongyup 
Published: January 2020

AbstractThe yellow‐legged hornet, Vespa velutina nigrithorax, is an invasive social wasp found in temperate regions and is recognized as a hazardous insect, as it often attacks humans and honeybees. Nidus vespae (nests of social wasps) are traditionally used as a medicinal ingredient; thus, V. v. nigrithorax may be useful as a biological resource. Extracts of Nidus vespae built by V. v. nigrithorax were examined for their antibacterial activity screening against six food‐borne pathogenic bacteria, and the ethyl acetate and butanol layer of the extract exhibited inhibitory activity against the pathogenic bacteria. We determined the antibacterial activity of Nidus vespae built by V. v. nigrithorax for the first time.
Cancer and changes in facial appearance: A meta‐ethnography of qualitative studies
Authors: Thompson Andrew R. , Sewards Iona , Baker Sarah R. 
Published: January 2020

IntroductionLiving with an altered facial appearance as a result of treatment for cancer requires considerable psychological adjustment. As such it is essential that health care professionals understand the lived experience of people affected. This systematic review provides a meta‐ethnography of studies that have explored the experience of changed facial appearance as a result of cancer.MethodsA search of four databases (Web of Science, CINAHL, PsycInfo, and Scopus) took place using terms relating to qualitative research, cancer, and changed facial appearance. Thirteen studies were identified, appraised, and included in the synthesis. The findings and interpretations within the studies were subject to meta‐ethnography procedures so as to elicit novel cross‐cutting themes.FindingsThe experience of changed facial appearance after cancer was clustered into three contexts. In the context of the disease, subthemes were the primacy of survival, the changing relationship with the disease, and the impact of the care team on the experience of changed appearance. In the context of the social world, subthemes were positive reactions, negative reactions, and coping strategies. In the context of the self, subthemes were the self under attack, self‐to‐self relating, the self in the world, and rebuilding the self.ConclusionsThe findings indicate that health care professionals must conduct holistic assessments, so as to fully recognize and where necessary address the impact upon self. The meta‐ethnography shows that the experience of facial appearance change following cancer is complex and requires awareness of a number of theoretical areas including identity construction, social support, stigmatization, and the specific literature on visible difference.
Statement of contribution

What is already known on this subject?

Changed facial appearance after cancer can cause significant social difficulties and impact on the sense of self.

The experience of managing the specific dual challenges of cancer and altered facial appearance is not clearly understood.

Recent studies that have focused specifically on the experience of changes in appearance after cancer have been limited in scope and transferability.

What does this study add?

To our knowledge, this is the first meta‐ethnography to bring together the literature on the impact of altered facial appearance following cancer.

Patients may feel unable to talk about appearance with health care professionals because it is seen as a frivolous issue.

Clinicians should facilitate open, person‐centred opportunities for patients to discuss the impact of changed appearance and where necessary facilitate access to support.
N‐locking stabilization of covalent helical peptides: Application to Bfl‐1 antagonists
Authors: Baggio Carlo , Udompholkul Parima , Gambini Luca , Jossart Jennifer , Salem Ahmed F. , Håkansson Maria , Perry J. Jefferson P. , Pellecchia Maurizio 
Published: January 2020

AbstractRecently, it was reported that tetrapeptides cyclized via lactam bond between the amino terminus and a glutamic residue in position 4 (termed here N‐lock) can nucleate helix formation in longer peptides. We applied such strategy to derive N‐locked covalent BH3 peptides that were designed to selectively target the anti‐apoptotic protein Bfl‐1. The resulting agents were soluble in aqueous buffer and displayed a remarkable (low nanomolar) affinity for Bfl‐1 and cellular activity. The crystal structure of the complex between such N‐locked covalent peptide and Bfl‐1 provided insights on the geometry of the N‐locking strategy and of the covalent bond between the agent and Bfl‐1.
Evidence for bradykinin release in chronic spontaneous urticaria
Authors: Hofman Zonne L.M. , van den Elzen Mignon T. , Kuijpers Jeffrey , de Maat Steven , Hack C. Erik , Knulst André C. , Röckmann Heike , Maas Coen 
Published: January 2020

AbstractBackgroundChronic spontaneous urticaria (CSU) is characterized by recurrent itchy weals and/or angioedema and is believed to be driven by mast cell activation. It was shown that excessive mast cell activation during anaphylaxis initiates contact activation, resulting in bradykinin release. Evidence for bradykinin release was never demonstrated in CSU.ObjectiveTo study biomarkers of bradykinin release in CSU.MethodsPlasma samples of CSU patients were collected during routine visits at the outpatient clinic. Cleaved high molecular weight kininogen (cHK) was used as a biomarker for bradykinin release. cHK, factor XIIa‐C1‐inhibitor (FXIIa‐C1‐INH), kallikrein‐C1‐INH, plasmin‐antiplasmin (PAP) complexes and soluble urokinase‐type plasminogen activator receptor (suPAR) levels were determined by ELISA. Clinical data and data on tryptase levels were collected from medical records. cHK levels were compared to previously determined levels in hereditary angioedema (HAE).ResultsOne hundred seventeen samples from 88 CSU patients and 28 samples from healthy controls were analysed. Median cHK level in CSU was 9.1% (range: 1.4%‐21.5%), significantly increased compared to healthy controls (median 6.0% range: 0%‐19.9%; P = .0005) and comparable to HAE (n = 46, median 10.3%, range 0%‐44.3%, P > .9999). cHK levels normalized in patients during disease remission (median 6.5% range 1.5%‐20.8%) but were not dependent on the presence of angioedema, acute angioedema attacks or response to antihistamines. Surprisingly, cHK levels were inversely correlated to serum tryptase (r = −0.65 P = .0137). C1‐INH complexes and suPAR levels were not elevated in patients compared to healthy controls. PAP‐complex levels in patients were elevated compared to healthy controls but there was no correlation between PAP‐complex and cHK levels.ConclusionscHK levels are elevated in symptomatic CSU patients compared to healthy controls, indicating increased bradykinin production. Increased cHK levels are not limited to patients with angioedema.Clinical relevanceIf elevated bradykinin generation has clinical implications in the pathology of CSU is open to debate.
A study comparing the clinical and hormonal profile of late onset and persistent acne in adult females
Authors: Sardana Kabir , Bansal Prekshi , Sharma Lokesh K. , Garga Umesh C. , Vats Gauri 
Published: January 2020

AbstractBackgroundAdult acne has been classified into two major subtypes: “persistent acne” and “late onset acne”. A surrogate marker of hyperandrogenism (HA) in adult female acne is the presence of clinical signs of HA and biochemical hyperandrogenemia. We compared the clinical and hormonal profiles of the two acne subtypes and evaluated the likely source of androgen excess – ovarian or adrenal.MethodsFemale acne patients 25 years of age and older were evaluated for clinical HA. Hormonal assessment included total testosterone (TT), sex hormone binding globulin (SHBG), free androgen index (FAI), anti‐Mullerian hormone (AMH), 17‐hydroxyprogesterone (17‐OHP), dehydroepiandrosterone sulfate (DHEAS), follicle stimulating hormone (FSH), luteinizing hormone (LH), thyroid stimulating hormone (TSH), and prolactin. DHEAS and 17‐OHP represented adrenal androgens and AMH indicated ovarian reserve.ResultsOf 120 cases, clinical HA was seen in 71.67% while biochemical hyperandrogenemia was detected in only 18.33% of patients. Though late onset was more common in adult acne patients (56.6%), the persistent acne subgroup (43.33%) had a younger age at onset, a past history of adolescent acne (51.92%), truncal predilection (44.23%), polycystic ovary syndrome (PCOS) (44.23%), significant presence of irregular menses (40.38%) and hirsutism (57.69%), and increased TT (13.46%), 17‐OHP (76.92%), AMH (44.23%), and increased LH/FSH (15.38%) ratio. PCOS was seen more in the persistent acne patients with clinical HA and increased 17‐OHP levels.ConclusionPersistent acne patients had marked clinical HA, PCOS, and hormonal abnormalities necessitating an endocrinological evaluation. As a corollary, this subgroup would benefit from antiandrogen therapy.
Does obesity impact the outcome of severely burned patients?
Authors: Pauzenberger Reinhard , Radtke Christine , Ederer Ines A. , Hacker Stefan , Waldmann Anna , Sternat Nikolaus , Franke Isabella , Thury Alexander , Harpain Lucie , Stievano Simona 
Published: January 2020

AbstractAlthough obesity appears to be an important predictor of mortality and morbidity, little data about the impact of body mass index (BMI) on the outcome of severely burned patients are available. Patients admitted to the General Hospital Vienna between 1994 and 2014, who underwent surgery because of burn injuries, were enrolled in this study. BMI was used to divide patients into five groups: BMI 18.5 to 24.9, 25 to 29.9, 30 to 34.9, 35 to 39.9, and > 40. The groups were compared in terms of difference of mortality and morbidity. Of 460 patients, 34.3% (n = 158) died. Mortality rates were the lowest in patients with obesity class III and the highest in patients with BMI 35 to 39.9 (BMI 18.5‐24.9: 30.5%, BMI 25‐29.9: 31.5%, BMI 30‐34.9: 41.3%, BMI 35‐39.9: 55.5%, BMI > 40: 30%; P = .031). BMI was not found to be an independent risk factor when corrected with age, percent total body surface area burned, full‐thickness burns, and inhalation injury. No significant differences in length of stay, inhalation trauma, pneumonia, wound infection, sepsis, and invasive ventilation were observed. BMI as an independent risk factor for severely burned patients could not be confirmed via multivariate analysis.
Airway management for neonates requiring ex utero intrapartum treatment (EXIT)
Authors: Mohammad Shazia , Olutoye Olutoyin A. 
Published: January 2020

AbstractIn utero congenital malformations in the fetus can occasionally lead to an obstructed airway at birth accompanied by hypoxic injury or peripartum demise, without intervention. Ex utero intrapartum treatment (EXIT) may help reduce morbidity and mortality associated with challenging airways by providing extra time on uteroplacental circulation to secure the airway. Meticulous preparation and planning are crucial for this procedure. Many different types of congenital malformations can result in a difficult airway, but there is no correlation between specific malformations and a required type of airway intervention. Based on our experience and literature review, an airway process flow diagram has been created to help assist teams in decision‐making for airway intervention in a neonate during the EXIT procedure. The management of the airway in this scenario involves additional unique considerations that accompany handling a partially delivered newborn in the uterine environment. Extensive preparation and team rehearsal are essential to the success of this procedure.
No evidence of calorie‐related modulation of N2 in food‐related Go/No‐Go training: A preregistered ERP study
Authors: Aulbach Matthias Burkard , Harjunen Ville Johannes , Spapé Michiel , Knittle Keegan , Haukkala Ari , Ravaja Niklas 
Published: January 2020

AbstractGo/No‐Go tasks, which require participants to inhibit automatic responses to images of palatable foods, have shown diagnostic value in quantifying food‐related impulses. Moreover, they have shown potential for training to control impulsive eating. To test the hypothesis that training modulates early neural markers of response inhibition, the current study investigated how the N2 event‐related brain potential to high‐ and low‐calorie food images changes along Go‐/No‐Go training and how the N2 is related to later eating behavior. 50 healthy adults, (mBMI = 23.01) first completed a food Go/No‐Go task in which high‐ and low‐calorie food images were accompanied by Go‐and No‐Go‐cues with equal frequency. Participants then completed a training block in which high‐calorie foods were predominantly paired with a No‐Go cue and the low‐calorie foods with a Go cue, followed by a block with reversed coupling (order of the training blocks counterbalanced between participants). After each training, there was a snacking opportunity during which calorie intake was measured. Against our preregistered hypotheses, the N2‐amplitudes were not significantly affected by the calorie‐content and there was no training‐related modulation in the N2. In addition , food intake was not influenced by the preceding training blocks and the N2 amplitude did not predict the food intake. Our study suggests that the link between N2 obtained in a food‐related Go/No‐Go task and impulse control is not clear‐cut and may be limited to specific task characteristics. The results are of high importance as they question the previously assumed mechanism of Go/No‐Go training in food‐related inhibitory control.
Conflicts of interest in dialysis: A barrier to policy reforms
Authors: Glickman Aaron , Lin Eugene , Berns Jeffrey S. 
Published: January 2020

AbstractConflicts of interest involving physicians are commonplace in the US, occurring across many different specialties and subspecialties in a variety of clinical settings. In nephrology, two important scenarios in which conflicts of interest arise are dialysis facility joint venture (JV) arrangements and financial participation in End‐stage Kidney Disease Seamless Care Organizations (ESCOs). Whether conflicts of interest occurring in either of these settings influence decision‐making or patient care outcomes is not known due to a lack of transparent, publicly available information, and opportunities to conduct independent study. We discuss possible benefits and risks of nephrologist's financial participation in JVs and ESCOs and possible mechanisms for disclosure and reporting of such arrangements as well as risk mitigation.
A Case for Using Hierarchical Linear Modeling in Exercise Science Research
Authors: Mitchell Sid , Loovis E. Michael , Butterfield Stephen A. 
Published: January 2020

Analyzing data in the exercise sciences can be challenging when trying to account for physical changes brought about by maturation (e.g., growth in height, weight, heart/lung capacity, muscle-to-fat ratio). In this paper, we present an argument for using hierarchical linear modeling (HLM) as an approach to analyzing physical performance data. Using an applied example from Butterfield, Lehnhard, Lee, and Coladarci, we will show why HLM is an appropriate analysis technique and provide other examples of where HLM will be beneficial.
Appearance and Persistence of Antibodies Against Different Virus Components After Regular Measles Infections
Authors: Norrby Erling , Gollmar Ylva 
Published: January 2020

Different measles virus-specific antibody activities in acute, early (11 to 40 days after rash) and late (4 to 20 years postinfection) convalescent sera and gamma globulin were determined. Early immunoglobulin G antibodies gave a poor neutralization, which was increased 10- to 60-fold by addition of anti-gamma globulin.
There was a high degree of correlation between titers of hemolysis-inhibiting (HLI) and hemagglutinating-inhibiting (HI) antibodies. However, in one out of fifteen late convalescent sera an HLI antibody titer of 640 in the presence of titer of only 20 in HI tests with Tween 80—either-treated antigen was found. Similar findings were made with sera from two patients with multiple sclerosis included in a parallel study. A somewhat higher titer of HI antibodies was demonstrable in these three sera when untreated material was used as antigen. These findings are interpreted in the following way. Antibodies against the hemagglutinin can block not only virus-specific agglutination but also lysis of red cells. In contrast, antibodies against the hemolysin, besides blocking the biological activity of this component, carry only a slight HI activity. This HI activity can be detected only by use of antigen preparations containing hemagglutinin-associated hemolysin.

Complement-fixation (CF) and immunodiffusion tests (the latter were carried out with antigen preparations treated with 0.25% sodium dodecyl sulfate) demonstrated that, in almost all cases, antibodies against nucleocapsid structures dominated quantitatively among antibodies appearing in connection with and persisting after regular measles infections. Generally, only low titers of antibodies reacting with purified small particle hemagglutinin (HA; 10 to 14
S
) or additional structural or nonstructural components were identified in CF and immunodiffusion tests.
PRODUCTION OF VIBRIO EL TOR TOXIN IN A LIQUID MEDIUM
Authors: Watanabe Yoshikazu , Felsenfeld Oscar 
Published: January 2020

Watanabe, Yoshikazu(U. S. Army Medical Center, Japan),and Oscar Felsenfeld. Production of vibrio El Tor toxin in a liquid medium. J. Bacteriol.82:43–47. 1961.—High toxin titers (as measured by mouth lethality and hemolytic activity) were obtained from culture supernatants of strains of El Tor vibrio isolated from patients in Indonesia. Cultivation of the organism in vitro revealed that the concentration of ferrous ion in the medium was critical for the production of maximal yields of toxin.Toxins produced under appropriate conditions were antigenic in rabbits and produced antibodies capable of neutralizing both the hemolytic and lethal actions in multiple proportion. Suggestive evidence has been obtained that the hemolytic and lethal toxins may be separate molecules.
The measurement of the $$H\rightarrow \tau \tau $$ signal strength in the future $$e^{+}e^{-}$$ Higgs factories
Authors: Yu Dan , Ruan Manqi , Boudry Vincent , Videau Henri , Brient Jean-Claude , Wu Zhigang , Ouyang Qun , Xu Yue , Chen Xin 
Published: January 2020

AbstractThe Circular Electron Positron Collider and the International Linear Collider are two electron-positron Higgs factories. They are designed to operate at a center-of-mass energy of 240 and 250 GeV and accumulate 5.6 and 2 $$ab^{-1}$$ab-1 of integrated luminosity. This paper estimates their performance on the $$H \rightarrow \tau ^{+}\tau ^{-}$$H→τ+τ- benchmark measurement. Using the full simulation analysis, the CEPC is expected to measure the signal strength to a relative accuracy of 0.8%. Extrapolating to the ILC setup, we conclude the ILC can reach a relative accuracy of 1.1% or 1.2%, corresponding to two benchmark beam polarization setups. The physics requirement on the mass resolution of the Higgs boson with hadronic decay final states is also discussed, showing that the CEPC baseline design and reconstruction fulfill the accuracy requirement of the $$H\rightarrow \tau ^{+}\tau ^{-}$$H→τ+τ- signal strength.
Anisotropic generalization of isotropic models via hypergeometric equation
Authors: Nasheeha R. N. , Thirukkanesh S. , Ragel F. C. 
Published: January 2020

AbstractWe study Einstein’s field equations to describe static spherically symmetric relativistic compact objects with anisotropic matter distribution, and generate two classes of exact solutions by choosing a generalized form for one of the gravitational potentials and a particular form for the measure of anisotropy. This is achieved by transforming the Einstein’s field equation to a hypergeometric equation. The generated models generalize the isotropic models of Durgapal–Bannerji, Tikekar and Vaidya–Tikekar. The physical viability of the model is examined and compared with observational results of strange star candidates.
A Corte Joanina no Rio de Janeiro
Authors: Viana Junior Fernando Santa Clara 
Published: January 2020

Este trabalho objetiva discutir a emergência de novos hábitos alimentares na capital fluminense, expressos pelos classificados do primeiro impresso brasileiro, a Gazeta do Rio de Janeiro, entre os anos de 1808-1821. Por meio do método de análise proposto pela pesquisadora Laurence Bardin, na obra Análise de Conteúdo (1977), buscamos identificar e apontar a emersão de produtos, bens e serviços nos classificados do impresso que sejam caros ao cotidiano alimentar das elites à época. Em paralelo a esta análise, contextualizaremos os feitos ligados ao Rei e seu séquito no período de estada da corte lusa no Brasil, rastreando alguns caminhos relacionados às modificações nas sensibilidades alimentares no período. Assim, ingredientes estrangeiros, louças importadas, produtos a la europeia, cozinheiros d’além-mar, negras escravizadas treinadas em cozinha e outros enunciados que se relacionem com a alimentação são parte do arsenal de análise. Outro viés de observação relaciona-se com a oferta de dados produtos, o custo e os sentidos atribuídos a eles frente à sociedade de grosso trato local.
O recorte repousa no período em que a corte lusa esteve no Rio de Janeiro, entre os anos de 1808 e 1821. Tal escolha está ligada diretamente à emergência de novos padrões de convivência, ao choque entre os padrões que já faziam parte da sociedade aristocrata brasileira e à emergência de hábitos criados em decorrência deste contato. Assim, conhecer os produtos alimentares anunciados nos classificados do impresso é possibilitar à História revisitar uma parte do passado e descortinar mais um possível olhar sobre o período.
O jornal foi fundado, junto à Imprensa Régia, em 13 de maio de 1808. Suas edições eram publicadas duas vezes por semana, às quartas e aos sábados, contando ainda com edições extraordinárias. Além do cotidiano local, o jornal versava sobre as decisões administrativas reais e o cenário internacional; nos classificados, tratava da venda, da compra e da oferta de um sem-fim de produtos e serviços, caros ao contexto do período. Este foi um dos vieses que subsidiaram a construção de um séquito local nos moldes do Antigo Regime à brasileira, para sustentar uma condução que se configurava e que ganhava novas dinâmicas à época.