bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased expression of immune checkpoint programmed cell death protein‐1 (PD‐1) on T cell subsets of bone marrow aspirates in patients with B‐Lymphoblastic leukemia, especially in relapse and at diagnosis
Authors: Park Sang Hyuk , You Eunkyoung , Park Chan‐Jeoung , Cho Young‐Uk , Jang Seongsoo , Im Ho‐Joon , Seo Jong‐Jin , Park Han‐Seung , Lee Jung‐Hee 
Published: April 2020

AbstractBackgroundWe analyzed expression profiles of immune checkpoint receptors on T cell subsets and ligands on leukemic blasts in patients with B‐lymphoblastic leukemia (B‐ALL).MethodsTotal 149 bone marrow (BM) samples obtained from 65 B‐ALL patients with four different clinical status (41 at diagnosis, 54 in complete remission [CR], 34 in persistence, and 20 in relapse), and 32 BM control samples were prospectively enrolled. Expression of immune checkpoint receptor (programmed cell death protein‐1 [PD‐1]) on T cell subsets and ligands (PD‐L1, PD‐L2) on leukemic blasts was evaluated by flow cytometry, and was compared between patient subgroups.ResultsRelapsed patients demonstrated highest PD‐1 expression proportion and intensity on CD3+CD4+ T cells with statistical significance when compared to patients in persistence/CR/BM controls (p = .027/<.001/<.001 and .012/.001/<.001, respectively). Newly diagnosed patients showed significantly lower PD‐1 expression proportion on CD3+CD4+ T cells than relapsed patients (p < .001), but their intensity was not significantly different. Relapsed patients showed significantly higher PD‐1 expression proportion and intensity on CD3+CD8+ T cells than patients in CR/BM controls (p = .022/.045 and .049/.005, respectively), but PD‐1 expression status on them were not significantly different between relapsed and newly diagnosed patients. PD‐L1/L2 expression on leukemic blasts was not significantly different between patient subgroups.ConclusionsIn BM aspirates from B‐ALL patients, PD‐1 expression on T‐cell subsets is increased at diagnosis, and to a greater extent, at relapse. These data suggest the potential usefulness of PD‐1 blockade in the treatment of B‐ALL, particularly at relapse.
Role of Lectin-like Oxidized LDL Receptor-1 and Syncytiotrophoblast Extracellular Vesicles in the Vascular Reactivity of Mouse Uterine Arteries During Pregnancy
Authors: Spaans Floor , Quon Anita , Kirschenman Raven , Morton Jude S. , Sawamura Tatsuya , Tannetta Dionne S. , Sargent Ian L. , Davidge Sandra T. 
Published: April 2020

AbstractVascular complications in pregnancy (e.g. preeclampsia) are a major source of maternal and foetal morbidity and mortality, and may be due to excessive release of placental syncytiotrophoblast-derived extracellular vesicles (STBEVs) into the maternal circulation. Increased activity of the multi-ligand scavenger receptor Lectin-like Oxidized LDL Receptor-1 (LOX-1) is associated with vascular dysfunction, and LOX-1 has been shown to interact with angiotensin II receptor type 1 (AT1). We hypothesized that STBEVs contribute to vascular dysfunction via LOX-1 and AT1 receptors during pregnancy. Uterine arteries from late pregnant wildtype and LOX-1 overexpressing mice were incubated overnight with or without STBEVs and vascular function was assessed using wire myography. STBEV-incubation decreased angiotensin II responsiveness only in wildtype mice, which coincided with decreased AT1 contribution and expression. Thus, STBEVs reduced angiotensin II responsiveness in normal pregnancy, but not in conditions of increased LOX-1 expression, suggesting that STBEVs (via LOX-1) play a role in normal adaptations to pregnancy. Oxidized LDL (a LOX-1 ligand) increased angiotensin II-induced vasoconstriction in STBEV-incubated arteries from both mouse strains, suggesting that the LOX-1 pathway may be involved in complicated pregnancies with elevated STBEVs and oxidized LDL levels (such as preeclampsia). These data increase our understanding of vascular complications during pregnancy.
Pilot study of a newly developed eLearning tool to teach CT and PET/CT in radiology and nuclear medicine
Authors: Heinzel Alexander , Marienhagen Jörg , Yekta-Michael Sareh Said , Mottaghy Felix M. , Krzemien Jennifer , Lemos Martin 
Published: April 2020

Abstract
Aim To test the usability and user experience of a newly self-developed eLearning tool to teach PET/CT and CT to undergraduate medical students.
Methods The eLearning tool permits to display PET and CT DICOM images web-based. It contains a healthy subject with anatomical annotations and a clinical case study. The usability and user experience of the eLearning tool was evaluated in undergraduate medical students of the medical faculty of the RWTH Aachen. We applied a survey based on different already existing and validated questionnaires such as System Usability Scale (SUS) and User Experience Questionnaire (UEQ-S) as well as specific questions regarding the eLearning tool.
Results 38 volunteers (9 males) participated in our study. Applying the SUS resulted in a mean of 82.24, and a median of 83.75. This positive evaluation is supported by the results of the UEQ-S that were 2.2 with regard to the pragmatic quality, 2.3 with regard to hedonic quality and 2.3 for overall quality indicating a very positive evaluation. In the free-text answers, students emphasised easy and intuitive use of the eLearning tool that was additionally described as interesting and exciting. The students also positively mentioned the case study and the possibility of practice-based learning. Negative aspects were mainly problems with synchronisation of the PET and CT images.
Conclusion The positive evaluation is encouraging and form a foundation for further development of the eLearning module. It may be the basis for the implementation of a sustainable blended learning concept in the nuclear medicine curriculum.
The Pransky interview: Dr. Matanya Horowitz, founder and CEO of AMP robotics
Authors: Pransky Joanne 
Published: April 2020

Purpose
This paper is a “Q&A interview” conducted by Joanne Pransky of Industrial Robot Journal as a method to impart the combined technological, business and personal experience of a prominent, robotic industry PhD-turned entrepreneur regarding his pioneering efforts of bringing technological inventions to market. The paper aims to discuss these issues.

Design/methodology/approach
The interviewee is Dr Matanya Horowitz, Founder and CEO of AMP Robotics, an industrial artificial intelligence (AI) and Robotics Company that automates the identification, sorting and processing of complex waste streams to extract maximum value for their customers. Horowitz discusses how he came to found this groundbreaking company and created disruptive innovations.

Findings
Horowitz earned four bachelor degrees in electrical engineering, computer science, applied mathematics and economics, as well as a master’s degree in electrical engineering, all from the University of Colorado. He also holds a PhD in control and dynamical systems from the California Institute of Technology with publications and research in control theory, AI, robotic path planning and computer vision. Shortly after finishing his PhD, he founded Louisville, Colorado-based AMP Robotics in 2014 with the mission of changing the fundamental economics of recycling. In the Fall of 2019, AMP raised $16m in Series A funding, led by Sequoia Capital.

Originality/value
Horowitz developed and commercialized AMP’s breakthrough AI platform, AMP Neuron™ and robotics system, AMP Cortex™, which automates high-speed identification, sorting, picking and processing of material streams. Horowitz was individually recognized as Waste360’s “2019 Innovator of the Year” in addition to being named in their “40 under 40” list. AMP has received numerous awards and gained international recognition, including The Circulars 2018 Award for “Circular Economy Top Tech Disruptor” at the World Economic Forum in Davos, and the NWRA’s (National Waste and Recycling Association) “2017 Innovator of the Year” award.
Consociationalism under examination: Is consociationalism the optimal multiculturalist approach for Turkey?
Authors: Kolçak Hakan 
Published: April 2020

AbstractSome scholars maintain that the Republic of Turkey should construct a consociational model to manage its ethno‐cultural diversity. This article suggests consociationalism is not the optimal multiculturalist approach for Turkey, where there is some degree of interethnic moderation between ethnic Kurds and Turks at the grassroots level. In the presence of this mass‐based moderation, a consociational formula is unlikely to provide Turkish political leaders with political incentives that urge them to cooperate and enter into consociational power‐sharing arrangements with their Kurdish counterparts. This renders consociational power‐sharing arrangements difficult to promote or enforce in Turkey. In the absence of such incentives, any multicultural reform of the consociational formula would not be sustainable in Turkey. There would simply not be enough popular support for such reforms. There are some electoral strategies that offer both majority and minority leaders political incentives to move toward the moderate middle, form interethnic coalitions, foster interculturalism, and increase the number of intercultural citizens. These strategies are offered by centripetalism, another multiculturalist approach to managing ethno‐cultural diversity.
Helicobacter pylori
and Neutrophils: Sialic Acid-Dependent Binding to Various Isolated Glycoconjugates
Authors: Miller-Podraza Halina , Bergström Jörgen , Teneberg Susann , Milh Maan Abul , Longard Marianne , Olsson Britt-Marie , Uggla Lotta , Karlsson Karl-Anders 
Published: April 2020

ABSTRACT

Helicobacter pylori
has been shown to agglutinate erythrocytes in a sialic acid-dependent manner. However, very few studies have examined relevant target cells in the human stomach. Neutrophils are required for the onset of gastritis, and the inflammatory reaction may be induced on contact between bacteria and neutrophils. In the present work, glycolipids and glycoproteins were isolated from neutrophils and were studied for binding by overlay with radiolabeled bacteria on thin-layer chromatograms and on membrane blots. There was a complex pattern of binding bands. The only practical binding activity found was sialic acid dependent, since treatment of glycoconjugates with neuraminidase or mild periodate eliminated binding. As shown before for binding to erythrocytes and other glycoconjugates, bacterial cells grown on agar bound to many glycoconjugates, while growth in broth resulted in bacteria that would bind only to polyglycosylceramides, which are highly heterogeneous and branched poly-
N
-acetyllactosamine-containing glycolipids. Approximately seven positive bands were found for glycoproteins, and the traditional ganglioside fraction showed a complex, slow-moving interval with very strong sialic-acid-dependent binding, probably explained by Fuc substitutions on GlcNAc.
Role of Keratinocyte Injury in Adherence ofStreptococcus pyogenes
Authors: Darmstadt Gary L. , Mentele Laurel , Fleckman Philip , Rubens Craig E. 
Published: April 2020

ABSTRACTKeratinocytes injured acutely by UVB light or lipopolysaccharide were used to test the hypothesis that keratinocyte injury promotes bacterial adherence and the development of group A streptococcal skin infections. Injury did not affect adherence to undifferentiated and differentiated keratinocytes, but keratinocyte differentiation promoted adherence four- to fivefold.
THE RESULTS OF IMPLEMENTATION OF THE UNIFIED STATE QUALIFICATION EXAMINATION OF PHARMACY STUDENTS AT DNIPROPETROVSK MEDICAL ACADEMY
Authors: Potapova T. M. , Sliesarchuk V. Yu. , Podpletnia O. A. , Lohvynenko N. V. 
Published: April 2020

The article analyzes the results of the Unified State Qualification Examination (USQE) implementation in order to assess the pharmacy students’ education level during the Krok-1 licensed integrated examination and to compare these results with the national indicators.
Considering that for the first time in 2019 a new qualitative assessment method of students’ knowledge has been introduced in Ukraine, both Ukrainian and foreign third year pharmacy students have had the USQ examination at Dnipropetrovsk Medical Academy (DMA), which included two components: Krok-1 licensed integrated examination and professional English. The analysis of the obtained results has revealed some shortcomings of the student training program and drawn an attention to the solution to these problematic issues.
This comprehensive assessment of the pharmacy students’ profile knowledge allows us to identify the training programs’ shortcomings and provides an opportunity to increase the effectiveness of study at the academy in order to integrate Ukrainian specialists in the world medicine.
Pesquisa sobre Criatividade em Contabilidade Gerencial: Visão Geral e Oportunidades de Pesquisa no Contexto Brasileiro
Authors: Aguiar, Doutor Andson Braga de , Suave Ricardo 
Published: April 2020

Criatividade representa fonte de vantagem competitiva para organizações e, por esse motivo, tem sido tema amplamente pesquisado em psicologia e administração (Speckbacher, 2017). Apesar da importância do tema, a ênfase predominante da pesquisa em contabilidade gerencial tem sido em examinar efeitos de sistemas de controle gerencial sobre desempenho dos indivíduos em tarefas rotineiras, ou seja, tarefas programáveis e repetítiveis (Brüggen, Feichter & Williamson, 2018). Apenas recentemente, a pesquisa em contabilidade gerencial começa a se preocupar com o efeito de controles gerenciais no desempenho em tarefas criativas as quais são de mais difícil previsibilidade e são não repetítiveis (Shields, 2015). No contexto brasileiro, em particular, estudos em contabilidade gerencial com ênfase em criatividade ainda são inexistentes. A importância em se entender o papel de controles gerenciais para estimular criatividade no ambiente de trabalho é permitir que sistemas de controle gerencial sejam desenhados de modo apropriado ao nível de criatividade desejado pelas organizações.
O propósito deste editorial é oferecer uma visão geral da pesquisa sobre criatividade em contabilidade gerencial e discutir oportunidades para pesquisas futuras no contexto brasileiro. Em particular, pretende-se abordar às seguintes questões: Como criatividade tem sido definida e operacionalizada na pesquisa em contabilidade gerencial? Controle e criatividade representam objetivos conflitantes? Quais controles gerenciais são examinados para explicar criatividade? Quais oportunidades de pesquisa existem sobre o tema no Brasil? A discussão em torno dessas questões é feita a partir de pesquisadores que têm dedicado particular atenção ao tema de criatividade, tais como, Michael Williamson, Isabela Grabner e Gerhard Speckbacher, em contabilidade gerencial, e Teresa Amabile e Robert Eisenberger, em psicologia e gestão.
Nontypeable Haemophilus influenzae isolates from the lower respiratory tract in Western Sichuan, China: MIC value of ofloxacin and Mutation characteristics of Quinolones Resistance determining region gene
Authors: Xiaolei Wang , Jiang Xie , YuanBiao Guo , ZhuJun Shao , BingQing Zhu , HuiMin Guo , LiLi Yang , HuaWei Liu , ZhanHao Wang , Jun Hu , LuFei Huang 
Published: April 2020

Abstract
Background: Fluoroquinolones are one of the most widely used antibiotics in the treatment of respiratory tract infections, and the mechanism of resistance to fluoroquinolones is considered to be related to the amino acid substitution of gyrA, gyrB, parC, and parE, the Quinolone Resistance-Determining Regions (QRDRs) of DNA cyclase type II topoisomerase and IV topoisomerase. The purpose of this study was to explore the molecular mechanism of quinolone resistance of Nontypeable Haemophilus influenzae(NTHi ) isolates and analyze the mutation law of the QRDRs gene. Results: MIC value of ofloxacin of 280 NTHi isolates from lower respiratory tract secretions in children group during 2003~2004 and in whole age group during 2013~2014 in Western Sichuan, China were monitored and the amino acid sequences of gyrA, gyrB, parC and parE gene in QRDRs were detected. The resistance rate of ofloxacin in adult group was 1.92% (n=52), while the NTHi strains with ofloxacin MIC value≥0.5 showed an upward trend in all age groups. No ofloxacin-resistant strains were found in 57 NTHi strains isolated from the children patient. Four amino acid substitutions were found in GyrA genes, four in GyrB, three in parC and nine in parE genes. The results showed that different amino acid replacement patterns of the gyrA , gyrB, parC and parE gene had different effects on ofloxacin MIC values. Conclusions: Ser-84-leu and asp-88-tyr/asn mutation of the gyrA, ser-84-lys/ile and ser -133-ala mutations of the parC and ala-400-val variation of the gyrB were the main factors leading to the increase of MIC value of ofloxacin of NTHi strains in Western Sichuan, China. It can be predicted that with the increase of quinolones exposure, the susceptibility of isolates from children to quinolones will be further reduced.
Experimental Investigation of the Influence of Chlorhexidine Gel on the Implant-Abutment-Connection
Authors: Mandlbauer Lisa , Alevizakos Vasilios , Othman Ahmed , Stoetzer Marcus , See Constantin von 
Published: April 2020

Abstract
Background The aim of this study was to determine the effect of chlorhexidine gel on removal torque of abutment prosthesis screws in vitro. Methods 60 implants (BEGO Semados ® S/RI 4.1, BEGO Implant Systems GmbH & Co. KG, Bremen, Germany) were embedded in acrylic resin for study set-up. The abutments (S/RI 4.1 SUB-TEC WI, BEGO Implant Systems GmbH & Co. KG, Bremen, Germany) were fixed with prothesis screws with 25 Ncm on the implants and were loaded for 10.000 cycles with 250N in a static material testing machine. The implemented study consisted of three groups (n=20). Group 1 (control group) were loaded under dry conditions. Group 2 was filled with a saliva substitute only (Sialin-Sigma solution, Sigmapharm Arzneimittel GmbH, Vienna, Austria), group 3 was filled with a saliva substitute and additional with chlorhexidine gel (Chlorhexamed 1% GEL, GlaxoSmithKline Consumer Healthcare GmbH & Co. KG, München, Germany). Statistical analysis was performed using ANOVA (significance level p<0.05). Results The control group showed the smallest range of removal torque (19.85 Ncm ± 1.42 Ncm) while group 2 showed 20.32 Ncm ± 2.61 Ncm and in group 3 was 19.74 Ncm ± 2.96 Ncm. No significant differences between the three groups were evaluated. Conclusions Within the limits of this in-vitro study, it can be concluded that the application of chlorhexidine gel did not show any significant effect on the removal torque on abutment screws after loading.
Clinical characteristics and laboratory indicator analysis of 69 COVID-19 pneumonia patients in Suzhou, China
Authors: Wang Yi , Yao Lin , Zhang Jian-Ping , Tang Pei-Jun , Ye Zhi-Jian , Shen Xing-Hua , Xu Jun-Chi , Wu Mei-Ying , Yu Xin 
Published: April 2020

Abstract
Background Sudden exacerbations and respiratory failure are major causes for the death of severe COVID-19 pneumonia patient and but now the detection and treatment of severe patients is still lack. Methods A retrospective analysis is conducted on 69 collected cases, which are about 69 patients with COVID-19 pneumonia who were admitted to the Suzhou Fifth People’s Hospital from January 1, 2020 to February 8, 2020. Their epidemiological, clinical and imaging characteristics as well as laboratory data of the 69 patients were analyzed. Results The study found fibrinogen increased in 45 (65.2%) patients and when the fibrinogen takes a critical value of 4.805 g/L, the sensitivity and specificity, helping distinguish general and severe classification, are 100% and 14%, respectively, which are significantly better than lymphocyte and myoglobin. Chest CT images indicate that the cumulative number of lung lobes in severe patients were significantly higher than that in general patients (P＜0.05) and the cumulative number of lung lobes in the lesions was negatively correlated with lymphocyte, and positively correlated with myoglobin and fibrinogen. Our study also found that there is no obvious effect of hormone therapy in severe patients with COVID-19. Conclusions Based on the retrospective analysis, the fibrinogen were found increased in severe patients and were better than lymphocyte and myoglobin in respect of distinguishing general and severe patients. And the study also suggested hormone treatment has no significant effect on COVID-19.
Clinical characteristics of COVID-19 in Fujian Province: a multicenter retrospective study
Authors: Wang Sijiao , Chen Zhisheng , Lin Yijian , Lin Li , Lin Qunying , Fang Sufang , Shi Yonghong , Zhuang Xibin , Ye Yuming , Wang Ting , Zhang Hongying , shao Changzhou 
Published: April 2020

Abstract
Background The coronavirus disease 2019 (COVID-19) has spread worldwide, leading to thousands of deaths. We aim to describe the epidemiological and clinical characteristics of patients with coronavirus disease 2019 (COVID-19) in Fujian province, China. Methods In this retrospective, multi-center study, we collected and analysed 165 patients of COVID-19 confirmed by real time PCR of nasopharyngeal swab specimens in five tertiary hospitals of Fujian province, China from Jan 22 to Feb 16, 2020. The final date of follow-up was February 21, 2020. Results Of the 165 hospitalized patients with COVID-19, 101 patients had relation with Wuhan within two weeks. Symptoms at illness onset mainly were fever (76.4%), cough (60%) and expectoration (38.2%). On admission, the severity of most patients were classified as mild or common and lymphopenia (33.9%), hypoxemia (15.2%), elevated and bilateral pneumonia (83.6%) was observed. Patients older than 65 years had significantly high frequency of hypertension, diabetes, severe classification, lymphopenia and hypoxemia than those younger than 65 years. Age correlated negatively with lymphocyte count and oxygenation index on admission while positively with duration from exposure to the time of negative RT-PCR. At the end of follow-up, 80 patients were discharged and one died. The median hospital stay was 17 days. Conclusions Patients with COVID-19 were mostly non-severe cases in Fujian province and older patients (>65 years) were more likely to have lymphopenia and hypoxemia, and to progress as severe cases of COVID-19 than those younger than 65.
An O(n3) time algorithm for the maximum weight b-matching problem on bipartite graphs
Authors: Rajabi-Alni Fatemeh , Bagheri Alireza , Minaei-Bidgoli Behrouz 
Published: April 2020

Abstract
Background: A matching between two sets A and B assigns some elements of A to some elements of B. Finding the similarity between two sets of elements by advantage of the matching is widely used in computational biology for example in the contexts of genome-wide and sequencing association studies. Frequently, the capacities of the elements are limited. That is, the number of the elements that can be matched to each element should not exceed a given number. Results: We use bipartite graphs to model relationships between pairs of objects. Given an undirected bipartite graph G = (A∪B,E), the b-matching of G matches each vertex v in A (resp. B) to at least 1 and at most b(v) vertices in B (resp. A), where b(v) denotes the capacity of v. We propose the ﬁrst O(n3) time algorithm for ﬁnding the maximum weight b-matching of G, where |A|+|B| = O(n). Conclusions: The b-matching has been studied widely for the bipartite graphs with integer weight edges. But our algorithm is the ﬁrst algorithm for the maximum (respectively minimum) b-matching problem with non positive real (respectively non negative real) edge weights.