bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers to healthcare access for Arabic-speaking population in an English-speaking country
Authors: Al Jumaili Ali A. , Ahmed Kawther K. , Koch Dave 
Published: May 2020

Objective: To identify barriers to healthcare access, to assess the health literacy levels of the foreign-born Arabic speaking population in Iowa, USA and to measure their prevalence of seeking preventive healthcare services.
Methods: A cross-sectional study of native Arabic speaking adults involved a focus group and an anonymous paper-based survey. The focus group and the Andersen Model were used to develop the survey questionnaire. The survey participants were customers at Arabic grocery stores, worshippers at the city mosque and patients at free University Clinic. Chi-square test was used to measure the relationship between the characteristics of survey participants and preventive healthcare services. Thematic analysis was used to analyze the focus group transcript.
Results: We received 196 completed surveys. Only half of the participants were considered to have good health literacy. More than one-third of the participants had no health insurance and less than half of them visit clinics regularly for preventive measures. Two participant enabling factors (health insurance and residency years) and one need factor (having chronic disease(s)) were found to significantly influence preventive physician visits.
Conclusions: This theory-based study provides a tool that can be used in different Western countries where Arabic minority lives. Both the survey and the focus group agreed that lacking health insurance is the main barrier facing their access to healthcare services. The availability of an interpreter in the hospital is essential to help those with inadequate health literacy, particularly new arriving individuals. More free healthcare settings are needed in the county to take care of the increasing number of uninsured Arabic speaking patients.
Tendencias didácticas de algunos docentes universitarios de matemáticas
Authors: Leguizamón José Francisco , Jiménez Alfonso , Chaparro Arley Zamir 
Published: May 2020

Se presenta un análisis sobre el quehacer docente de profesores de la Licenciatura en Matemáticas de la Universidad Pedagógica y Tecnológica de Colombia, que puede considerarse como un punto de partida para mejorar las prácticas de aula. El enfoque teórico es el de modelos de clase propuesto por Porlán, complementado con el constructivismo clásico de Piaget, el enfoque sociocultural de Vygotsky y el interaccionismo de Bruner. La metodología de investigación es mixta, con alcance descriptivo. Los instrumentos de recolección de información fueron los cuestionarios y la entrevista no estructurada. Los resultados muestran que la mayoría de los docentes que participaron en el estudio: diseñan sus clases con base en objetivos operacionales; evalúan mediante la aplicación de pruebas objetivas, planteadas especialmente como guías; y consideran que el aprendizaje ocurre mediante un proceso progresivo de asimilación de concepto. De acuerdo con lo anterior, se evidencia que las características de las prácticas de los profesores se asocian con una tendencia didáctica tecnológica.
Prevalence and Factors Associated With Malnutrition in Children Aged 6-59 Months in Jubek State, South Sudan.
Authors: Iyya Martin Adelino , Grace Ndeezi , Nicolette Nabukeera Barungi , Chollong Hassan 
Published: May 2020

Abstract
Background: Rates of acute malnutrition have been consistently higher in South Sudan than any other country in sub-Saharan Africa, according to South Sudan Household Survey 2010, the prevalence of Global Acute Malnutrition in children under 5 years was 22%, Prevalence of stunting is 45% and underweight was 48%. This study sought to determine the prevalence and factors associated with malnutrition among children aged 6-59 months in Jubek state, South Sudan. Methods: This was a cross sectional analytical community based study to assess the prevalence and factors associated with malnutrition among children aged 6-59 months in Jubek state, South Sudan. Data was collected using a structured questionnaire from 396 children. Anthropometric measurements were taken and a blood sample by finger prick was removed for HIV test. The equipment which were used included: WHO recommended MUAC tape for 6months to 59 months old children, digital weighing scale (SECA) and portable Stadiometers. Results: The analysis of this study revealed that, 32.2%, 28.2% and 32.3% of children were stunted, wasted and underweight respectively. The main associated factors of stunting were age older than one year (p= 0.004), children from households who were renting their houses and children who defecate in open spaces with no latrine at their homes (p= 0.015). Underweight was associated with child’s age (p= 0.001), loss of appetite (p=<0.001), children who ate from own plate (p=0.001) and children who didn’t consume meat (p=0.007). Male genders (p=0.022), households with two or more children aged zero to five years (0.010) not consuming vitamin A rich vegetable (p=0.002), diarrheal disease within two weeks prior to interview (p=0.006) and those from households with water sources other than piped (<0.001) were also associated with wasting. Conclusion: The general objective of this study was to assess the nutritional status of children aged 6-59 months in Jubek state, South Sudan. This study showed that the levels of stunting, wasting and underweight were high, one in three children were likely to be stunted (32.1%), or wasted (28.2%) or underweight (32.3%).
Motivation of disabled athletes for sport activities: validity and reliability of the Lithuanian version of the sport motivation scale
Authors: Sabaliauskas Stanislav 
Published: May 2020

The aim of the research was to evaluate the structural validity of the Lithuanian version of the Sports Motivation Scale in the context of the disability sport. This study included 66 athletes with hearing and visual impairment (45 men and 21 women). The average age of the research participants was 26.5 ± 11.7 years, they used to participate in sport activity for 10.1 ± 7.6 years. Athletes who participated in the research were representatives of goalball, tennis, athletics, swimming, basketball and other sports. 39 athletes were prize winners in World and European championships. The participants of the research completed the questionnaire based on the Sports Motivation Scale (SMS) already adapted in Lithuania. Data were processed using Jamovi program. SMS psychometric parameters demonstrated good internal scale compatibility. In the confirmatory factor analysis, a 4-factor model suitable for data analysis (CFI – 0.881; TLI - 0.863; RMSEA - 0.0710; χ2 / df 1.439) was identified which comprised 20 SMS items. The structure of the model consisted of factors that characterize athletes' intrinsic motivation – “to discover” (1), intrinsic motivation – “to feel self-improvement” (2), extrinsic motivation – “need for social dependency” (3) and “amotivation” (4).
Detoxification-related gene expression accompanies anhydrobiosis in the foliar nematode (Aphelenchoides fragariae)
Authors: Fu Zhen , Agudelo Paula , Wells Christina E. 
Published: May 2020

Abstract
The foliar nematode (Aphelenchoides fragariae) is a quarantined pest that infects a broad range of herbaceous and woody plants. Previous work has demonstrated its remarkable ability to survive rapid and extreme desiccation, although the specific molecular mechanisms underlying its anhydrobiotic response have not been characterized. The authors used RNA sequencing and de novo transcriptome assembly to compare patterns of gene expression between hydrated and 24-hr desiccated nematodes. In total, 2,083 and 953 genes were significantly up- and downregulated, respectively, in desiccated nematodes. Of the 100 annotated genes with the largest positive fold-changes, more than one third encoded putative detoxification-related proteins. Genes encoding enzymes of Phase I and Phase II detoxification systems were among the most strongly upregulated in the transcriptome, including 35 cytochrome p450s, 23 short chain dehydrogenase/reductases, 5 glutathione-S-transferases, and 22 UDP-glucuronosyltransferases. Genes encoding heat shock proteins, unfolded protein response enzymes, and intrinsically disordered proteins were also upregulated. Anhydrobiosis in A. fragariae appears to involve both strategies to minimize protein misfolding and aggregation, and wholesale induction of the cellular detoxification machinery. These processes may be controlled in part through the activity of forkhead transcription factors similar to Caenorhabditis elegans’ daf-16, a number of which were differentially expressed under desiccation.
Description and molecular phylogeny of Mesocriconema abolafiai n. sp. (Nematoda: Criconematidae) from Iran
Authors: Karani Hossein Mirbabaei , Eskandari Ali , Ghaderi Reza , Karegar Akbar 
Published: May 2020

Abstract

Mesocriconema abolafiai n. sp. is described by morphological, morphometric, and molecular approaches. The new species is characterized by a body slightly curved with 402 to 612 μm length, 90 to 113 cuticular body annuli with smooth to irregular margins lacking of crenation with not more than one anastomoses, lip region not offset, small flattened submedian lobes, stylet robust (52.8-60.0 µm) with well-developed knobs, open vulva with simple anterior lip, straight vagina, filled spermatheca with globular sperms, presence of males, and conical-acute tail with last annulus bilobed or rounded. Discussions are made on the characterization of M. abolafiai n. sp. from the most closely related species, M. ozarkiense, and several other species having similar tail shape. Furthermore, results of phylogenetic analyses inferred from D2 to D3 expansion fragments of 28S rRNA, 18S rRNA, and ITS rRNA gene sequences revealed the phylogenetic position of the new species within representatives of Criconematidae and supported morphological justifications for considering this population from Iran as a new species in the genus Mesocriconema.
Geo-spatial distribution of fluoride in drinking water resources in Eastern Iran
Authors: Nourafrouz Nourahmad , Naghizadeh Ali , Mansouri Borhan , Biglari Hamed , Derakhshani Elham , Thakkar Vaibhav 
Published: May 2020

Abstract
The purpose of this study was to determine the fluoride concentrations in drinking water of the Khaf County in Eastern Iran. Moreover, health risk assessment of three age groups (children, teens and adults), sensitivity analysis and uncertainties in the risk estimates were carried out using Monte Carlo simulation. For this reason, drinking water in 33 villages and 5 cities of the Khaf County were collected during March to September 2018. Fluoride contents in drinking water samples were assayed by using a HACH-DR6000 spectrophotometer. Fluoride content in drinking water from urban area and rural area ranged from 0.50 to 0.91 mg L−1 and 0.24 to 2.31 mg L−1. Among the population of the 33 villages, about 17 villages, corresponding to 51%, receive ﬂuoride concentrations less than 0.5 mg L−1 (minimum allowable concentration recommended by WHO), while the population of 4 villages, corresponding to 12%, receive ﬂuoride concentrations higher than 1.5 mg L−1 (the maximum allowable concentration of fluoride in drinking water recommended by the WHO). Moreover, our findings showed that the drinking water ingestion rate, ﬂuoride concentration in water, and the fraction of skin in contact with water were the most important variable in calculating the Hazard quotient (HQ).
Pharmacophore Generation, Quantitative Structure-Activity Relationship (QSAR), and Molecular Dynamic Simulation of Newly Substituted N-(6- Chloro-3-cyano-4-phenyl-4H-chromen-2-yl)-2-(4-chloro-phenoxy)-acetamide for Anticancer Activity
Authors: Chauhan Divya , Kumar Sushil , Hashim Syed Riaz , Raj Vinit 
Published: May 2020

Objective:
The main objective of the study was to develop the Quantitative Structure-
Activity Relationship (QSAR) and pharmacophore model by using data obtained from HT-29
cells to develop potent lead molecule for the scientific community.

Materials and Methods:
Common pharmacophore model, atom-based 3D-QSAR, and molecular
dynamic (MD) simulation were carried out via computational techniques by using 4H-chromene
derivatives.

Results:
The reliable common pharmacophoric hypothesis, DHH13 was generated and 3.95 survival
value was also found. Furthermore, the statistically significant 3D-QSAR model was developed
where r2=0.52 was found by using the Partial least squares (PLS) regression method. Phase
predicted activity and Log GI50 demonstrated an important atomic position in the structure of ligands
to ascertain anti colon cancer activity. Also, MD simulation was carried out between top
rank leads targeting IL-6 that provided better binding conformational and complex stability into
the active pocket site of the target throughout the MD simulation.

Conclusion:
The outcome of this design shows that the pharmacophore model and 3D-QSAR
might be helpful for researchers in the field of medicinal chemistry to design and develop potential
anti colon cancer compounds.
A Pre-Post Study of Vitamin D Supplement Effects on Urinary Megalin: The Emerging Predictive Role of Megalin in Diabetic Nephropathy Progression
Authors: Kasabri Violet , Akour Amal , Bulatova Nailya , Suyagh Maysa , Yousef Al Motassem , Al Hawari Hussein , Al Shelleh Sameeha , Bzour Jameel , Fahmawi Hiba 
Published: May 2020

Introduction:
Megalin is a renal proximal tubular protein that reabsorbs vitamin D from
glomerular filtrates. Previous studies found significantly higher levels of urinary megalin in chronic
microvascular complications of diabetes with associated metabolic derangements. This study aimed at
testing the effect of vitamin D supplements on urinary megalin levels in diabetic nephropathy (DN)
patients with vitamin D hypovitaminosis.

Methods:
Sixty-three participants with vitamin D deficiency and diabetic nephropathy (DN) were enrolled
in the pre-post study; urinary megalin levels with various clinical parameters and serum levels of
vitamin D3 were measured and compared to the baseline at 3- and 6-month intervals.

Results:
Interestingly, a supplementation related increase in serum vitamin D3 levels at 3- and 6-
month interventions affected a constellation of ameliorations in the DN progression of clinical and
metabolic factors. There was a decrease in ACR with a concomitant decrease in urinary megalin and a
decrease in blood pressure, fasting plasma glucose (FPG), and low-density lipoprotein – cholesterol
(LDL-C) – but an increase in glomerular filtration rate (GFR). Principally, pellet urinary megalin associated
positively (p < 0.05) with vitamin D hypovitaminosis and the albumin-to-creatinine ratio (ACR)
but negatively (p < 0.05) with Ca2+ and body mass index (BMI).

Conclusion:
Vitamin D supplementation could elucidate underlying pathophysiological mechanisms
and a prognostic significance of urinary megalin association with DN, obesity/MetS-related dyslipidemia,
and hyperglycemia modification. Megalin is a putative sensitive and precise predictive marker
and an emerging therapeutic target of renal anomalies.
Antibacterial and Synergistic Effects of Aqueous and Methanol Extracts of Artemisia annua Against Multidrug-resistant Isolates of Acinetobacter
Authors: Shadifar Hanieh , Bahreini Masoumeh , Khameneh Bahman , Emami Seyed A. , Fatemi Narges , Sharifmoghadam Mohammad R. 
Published: May 2020

Background:
Acinetobacter is one of the most important pathogens that causes a high
prevalence of infection in clinical centers. Natural products are major sources of new anti-infective
agents and considered as an alternative medicine for the treatment of infectious diseases.

Objective:
This study aims to evaluate the antibacterial activity of aqueous and methanol extract of
Artemisia annua on the clinically isolated Acinetobacter and the combination of the plant extract
with amikacin and imipenem.

Methods:
The aqueous and methanol extract of the aerial parts of this plant was prepared by maceration.
Antibacterial activity was determined by the Broth microdilution method . The presence of
adeI and adeB genes in Acinetobacter isolates was investigated. The combination effects of antibiotics
were performed using the checkerboard method. The effect of plant extract on bacterial efflux
pumps was also investigated.

Results:
MIC values of the methanol extract of A. annua were from 4.46 mg/ml to 8.92 mg/ml.
The effects of the interaction of the plant extract with the amikacin and imipenem represent a significant
synergistic influence. Findings indicated that the plant extract was able to inhibit the efflux
pump remarkably.

Conclusion:
The combination of the plant extract with amikacin and imipenem can be used in the
treatment of infections caused by antibiotic-resistant Acinetobacter and probably other infectious
diseases.
Experimental and Bioinformatical Studies on Antimalarial Drug Sulfadiazine
Authors: Zelai Noha 
Published: May 2020

Background:
Several computational tools assist in predicting the chemical properties,
toxicity, solubility, and binding affinity of the drugs.

Objective:
The study aims to experimentally analyze the efficiency of the antimalarial drug “sulfadiazine”
in a higher dose in contrast to its conventional use.

Methods:
The antimalarial drug was screened, and its application was assessed on the host (mice).

Results:
The results showed that parasitemia of the infected control group was significantly higher
than the others (P<0.0001) on days 3, 5, 7, and 9. The parasitemia of the IT+4 group was significantly
lower than the parasitemia of the IT-4 group on the 15th day.

Conclusion:
It was concluded that increased potency for the antimalarials is because they are nontoxic.
Nanotechnological Improvement of Veterinary Anthelmintics
Authors: Sanabria Rodrigo 
Published: May 2020

:
Helminths infections are among the most important problems in animal health and husbandry.
Moreover, zoonotic helminths endanger rural communities, particularly in developing countries.
Helminthiasis are not only important in relation to the harmful effects of parasites; additional
issues like anthelmintic resistance spread became more important over time.

:
As new anthelmintic development takes many years and millions of dollars of investment, some
strategies are currently focused on the modification of already available drugs, in order to improve
their efficacy and overcome their limitations. In this field, nanotechnology has brought a novel approach,
showing advantages like the regulation of the drug’s delivery and kinetics, reaching of specific
targets, and possibilities to avoid the systemic spread and side effects.

:
Taking this into account, the present review aims to introduce some of the current knowledge in anthelmintic
improvement based on nanotechnology, and how researchers could benefit from this technology
in order to overcome the drugs limitations.

:
Finally, some insights into potential field applications are discussed, based on the most important
concerns of current anthelmintic therapy.
MOTOR SKILLS OF SOCCER PLAYERS AGED 16-18 IN REGARD TO COMPETITION LEVEL AND PLAYING POSITION
Authors: Momčilović Zoran , Marković Srđan , Bogavac Dragana , Milosavljević Đukić Tatjana , Bugarski Srđan 
Published: May 2020

TThe aim of this paper was to examine the differences in the motor skills of soccer players aged 16-18 years who play in different competition levels (National League and Regional League), as well as players who play in different positions in the team. The standard testing battery for the motor skills assessment of soccer players was used to evaluate the motor skills. As for the evaluation of the differences between the different playing positions, a two-factor ANOVA with the factor Competition Level (National and Regional Level) and the factor Position (forward, midfielder, side defender, central defender) was used. A two-factor ANOVA with the factor Competition Level (National and Regional Level) and the factor Age (16, 17 and 18 years of age) was used to evaluate the differences between the different quality levels. The study included 126 male soccer players 16 to 18 years of age (N16=45, N17=41, N18=40) divided into 4 positions on the team: forwards (N=37, BH=179.2±5.0, BM=70.1±6.6), midfielders (N=48, BH=177.9±6.3, BM=69.6±7.9), side defenders (N=22, BH=176.6±5.4, BM=67.5±5.7) and central defenders (N=19, BH=184.0±4.3, BM=72.3±6.6). Because of significantly different activities in the field, the goalkeeper position was excluded from this study. The results indicate that motor skills do not differentiate players of different competition levels, and that there is a gap between players aged 18 years in aerobic endurance which is the basis of success in soccer. Also, the obtained results suggest that motor skills could differentiate players at certain positions. However, it was specifically found that only alactic capabilities type of speed and agility, differentiate forwards from other positions, especially from midfielders.
Modulatory Effects of Honey on Gastric Acidity and Plasma Postprandial Bicarbonate in Wistar Rats
Authors: Apugo Uchechukwu Ifeanyichukwu , Obia Onyebuchi 
Published: May 2020

Introduction: Honey is a naturally occurring sweet substance of plant origin composed mainly of fructose, glucose, water, antioxidants and other constituents. Its enormous constituents confer it with medicinal and nutritive usefulness.
Objectives: To assess the modulatory effects of honey on gastric acidity and plasma postprandial bicarbonate in wistar rats.
Method: A total of 24 male wistar rats weighing 200-250g were divided into four groups of six rats each; Group I served as control, Group II received 50% Honey (10ml/kg), Group III received omeprazole (20mg/kg) and Group IV received a combination of Omeprazole and Honey. The pH of gastric effluents in each rat was measured 15, 30 and 45mins using a pH meter after administration of the respective substances in each group.
Result and Discussion: Both honey and omeprazole respectively caused significant increases in the pH of gastric effluents, however, while that of honey was slow and steady, that of omeprazole was sharp and sustained. The 45-min pH level of omeprazole group was significantly higher than that of honey group. The combined group showed an initial sharp rise similar to omeprazole alone but gradually declined in the succeeding time interval. A combination of omeprazole and honey resulted in 27% reduction in the postprandial serum bicarbonate whereas omeprazole alone caused 41% reduction
Conclusion: The present study concludes that honey modulated gastric pH to levels possibly favourable to gastric function by either a direct action of reducing gastric acidity or acting as an antacid or both. Honey therefore could be described as a buffer in omeprazole stimulated gastric acid inhibition and a potential antacid.
Keywords: Honey, Gastric acidity, Gastric pH, bicarbonate.