bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yang–Mills Measure and the Master Field on the Sphere
Authors: Dahlqvist Antoine , Norris James R. 
Published: May 2020

AbstractWe study the Yang–Mills measure on the sphere with unitary structure group. In the limit where the structure group has high dimension, we show that the traces of loop holonomies converge in probability to a deterministic limit, which is known as the master field on the sphere. The values of the master field on simple loops are expressed in terms of the solution of a variational problem. We show that, given its values on simple loops, the master field is characterized on all loops of finite length by a system of differential equations, known as the Makeenko–Migdal equations. We obtain a number of further properties of the master field. On specializing to families of simple loops, our results identify the high-dimensional limit, in non-commutative distribution, of the Brownian bridge in the group of unitary matrices starting and ending at the identity.
The use of whole-body cryotherapy: time- and dose-response investigation on circulating blood catecholamines and heart rate variability
Authors: Louis Julien , Theurot Dimitri , Filliard Jean-Robert , Volondat Marielle , Dugué Benoit , Dupuy Olivier 
Published: May 2020

Abstract
Purpose
A predominance of parasympathetic drive is observed following cold exposure. Such modulation of the autonomic nervous system (ANS) is associated with faster post-exercise recovery. Within this context, whole-body cryotherapy (WBC) has been spreading in sport medicine, though the optimal temperature and frequency are unclear. The aim of this study was to examine the effects of different cryotherapy conditions on the sympathovagal balance.

Methods
Forty healthy males were randomly assigned into five different groups (− 110 °C, − 60 °C, − 10 °C, control temperature [≃ 24 °C]) and undertook 5 WBC sessions over 5 consecutive days. Cardiac autonomic activity was assessed through heart rate variability (HRV) using power density of high frequency (HF), root-mean square difference of successive R–R intervals (RMSSD) and sympathovagal balance (LF/HF). Systemic sympathetic activity was assessed via circulating blood catecholamines.

Results
Mean weekly RMSSD (pre: 48 ± 22 ms, post: 68 ± 29 ms) and HF (pre: 607 ± 692 ms2, post: 1271 ± 1180 ms2) increased (p < 0.05) from pre to post WBC, only in the − 110 °C condition. A rise in plasma norepinephrine was found after the first − 110 °C WBC session only (pre: 173 ± 98, post: 352 ± 231 ng L−1, p < 0.01); whereas, it was not significant after the 5th session (pre: 161 ± 120, post: 293 ± 245 ng L−1, p = 0.15).

Conclusion
These results suggest that one − 110 °C WBC exposure is required to stimulate the ANS. After five daily exposures, a lower autonomic response was recorded compared to day one, therefore suggesting the development of physiological habituation to WBC.
MSC encapsulation in alginate microcapsules prolongs survival after intra-articular injection, a longitudinal in vivo cell and bead integrity tracking study
Authors: Khatab Sohrab , Leijs Maarten J. , van Buul Gerben , Haeck Joost , Kops Nicole , Nieboer Michael , Bos P. Koen , Verhaar Jan A. N. , Bernsen Monique , van Osch Gerjo J. V. M. 
Published: May 2020

AbstractMesenchymal stem cells (MSC) are promising candidates for use as a biological therapeutic. Since locally injected MSC disappear within a few weeks, we hypothesize that efficacy of MSC can be enhanced by prolonging their presence. Previously, encapsulation in alginate was suggested as a suitable approach for this purpose. We found no differences between the two alginate types, alginate high in mannuronic acid (High M) and alginate high in guluronic acid (High G), regarding MSC viability, MSC immunomodulatory capability, or retention of capsule integrity after subcutaneous implantation in immune competent rats. High G proved to be more suitable for production of injectable beads. Firefly luciferase-expressing rat MSC were used to track MSC viability. Encapsulation in high G alginate prolonged the presence of metabolically active allogenic MSC in immune competent rats with monoiodoacetate-induced osteoarthritis for at least 8 weeks. Encapsulation of human MSC for local treatment by intra-articular injection did not significantly influence the effect on pain, synovial inflammation, or cartilage damage in this disease model. MSC encapsulation in alginate allows for an injectable approach which prolongs the presence of viable cells subcutaneously or in an osteoarthritic joint. Further fine tuning of alginate formulation and effective dosage for might be required in order to improve therapeutic efficacy depending on the target disease.
Validation of risk models for control of leaf blotch diseases in wheat in the Nordic and Baltic countries
Authors: Jørgensen Lise Nistrup , Matzen Niels , Ficke Andrea , Nielsen Ghita C. , Jalli Marja , Ronis Antanas , Andersson Björn , Djurle Annika 
Published: May 2020

AbstractRisk models for decisions on fungicide use based on weather data, disease monitoring, and control thresholds are used as important elements in a sustainable cropping system. The need for control of leaf blotch diseases in wheat (caused by Zymoseptoria tritici, Parastagonospora nodorum and Pyrenophora tritici-repentis) vary significantly across years and locations. Disease development is mainly driven by humidity events during stem elongation and heading. Two risk models were tested in field trials in order to identify situations favourable for the development of leaf blotch diseases in Lithuania, Norway, Sweden, Finland and Denmark. The Crop Protection Online (CPO) model uses days with precipitation (>1 mm), while the humidity model (HM) uses 20 continuous hours with relative humidity (RH) ≥ 85% as criteria for the need of a fungicide application. Forty-seven field trials were carried out during two seasons to validate these two risk-models against reference fungicide treatments. The season 2018 was dry and 2019 had an average precipitation profile. The two risk models with few exceptions provided acceptable disease control. In 2018, very few treatments were recommended by the models, saving 85–98% of treatments compared to the reference treatments, while in the wetter season 2019, 31% fewer applications were recommended. Based on specific criteria including fungicide input and net yield responses the models gave correct recommendations in 95% of the trials in 2018 and in 54–58% of the trials in 2019 compared with reference treatments dominated by 2–3 sprays. In comparison with single spray references, the models gave correct recommendations in 54–69% of the situations.
Molecular signature of eutopic endometrium in endometriosis based on the multi-omics integrative synthesis
Authors: Prašnikar Erika , Knez Jure , Kovačič Borut , Kunej Tanja 
Published: May 2020

Abstract
Purpose
To synthesise data from genome-wide studies reporting molecular signature of eutopic endometrium through the phases of the menstrual cycle in endometriosis.

Methods
Extraction of data from publications reporting genetic signatures characterising endometrium associated with endometriosis. The nomenclature of extracted differentially expressed transcripts and proteins was adopted according to the HUGO Gene Nomenclature Committee (HGNC). Loci were further sorted according to the different phases of the menstrual cycle, i.e. menstrual (M), proliferative (P), secretory (S), early-secretory (ES), mid-secretory (MS), late-secretory (LS), and not specified (N/S) if the endometrial dating was not available. Enrichment analysis was performed using the DAVID bioinformatics tool.

Results
Altered molecular changes were reported by 21 studies, including 13 performed at the transcriptomic, 6 at proteomic, and 2 at epigenomic level. Extracted data resulted in a catalogue of total 670 genetic causes with available 591 official gene symbols, i.e. M = 3, P = 188, S = 81, ES = 82, MS = 173, LS = 36, and N/S = 28. Enriched pathways included oestrogen signalling pathway, extracellular matrix organization, and endothelial cell chemotaxis. Our study revealed that knowledge of endometrium biology in endometriosis is fragmented due to heterogeneity of published data. However, 15 genes reported as dysregulated by at least two studies within the same phase and 33 significantly enriched GO-BP terms/KEGG pathways associated with different phases of the menstrual cycle were identified.

Conclusions
A multi-omics insight into molecular patterns underlying endometriosis could contribute towards identification of endometrial pathological mechanisms that impact fertility capacities of women with endometriosis.
Genetic and morphologic determination of diatom community composition in surface sediments from glacial and thermokarst lakes in the Siberian Arctic
Authors: Huang S. , Herzschuh U. , Pestryakova L. A. , Zimmermann H. H. , Davydova P. , Biskaborn B. K. , Shevtsova I. , Stoof-Leichsenring K. R. 
Published: May 2020

AbstractLakes cover large parts of the climatically sensitive Arctic landscape and respond rapidly to environmental change. Arctic lakes have different origins and include the predominant thermokarst lakes, which are small, young and highly dynamic, as well as large, old and stable glacial lakes. Freshwater diatoms dominate the primary producer community in these lakes and can be used to detect biotic responses to climate and environmental change. We used specific diatom metabarcoding on sedimentary DNA, combined with next-generation sequencing and diatom morphology, to assess diatom diversity in five glacial and 15 thermokarst lakes within the easternmost expanse of the Siberian treeline ecotone in Chukotka, Russia. We obtained 163 verified diatom sequence types and identified 176 diatom species morphologically. Although there were large differences in taxonomic assignment using the two approaches, they showed similar high abundances and diversity of Fragilariceae and Aulacoseiraceae. In particular, the genetic approach detected hidden within-lake variations of fragilarioids in glacial lakes and dominance of centric Aulacoseira species, whereas Lindavia ocellata was predominant using morphology. In thermokarst lakes, sequence types and valve counts also detected high diversity of Fragilariaceae, which followed the vegetation gradient along the treeline. Ordination analyses of the genetic data from glacial and thermokarst lakes suggest that concentrations of sulfate (SO42−), an indicator of the activity of sulfate-reducing microbes under anoxic conditions, and bicarbonate (HCO3−), which relates to surrounding vegetation, have a significant influence on diatom community composition. For thermokarst lakes, we also identified lake depth as an important variable, but SO42− best explains diatom diversity derived from genetic data, whereas HCO3− best explains the data from valve counts. Higher diatom diversity was detected in glacial lakes, most likely related to greater lake age and different edaphic settings, which gave rise to diversification and endemism. In contrast, small, dynamic thermokarst lakes are inhabited by stress-tolerant fragilarioids and are related to different vegetation types along the treeline ecotone. Our study demonstrated that genetic investigations of lake sediments can be used to interpret climate and environmental responses of diatoms. It also showed how lake type affects diatom diversity, and that such genetic analyses can be used to track diatom community changes under ongoing warming in the Arctic.
Chromium(VI) reduction and accumulation on the kaolinite surface in the presence of cationic soil flocculant
Authors: Szewczuk-Karpisz Katarzyna , Fijałkowska Gracja , Wiśniewska Małgorzata , Wójcik Grzegorz 
Published: May 2020

Abstract
Purpose
Heavy metal soluble forms pose a threat to plants, soil microflora, and microfauna. To limit their toxicity and mobility, various immobilizing additives are being developed. The main aim of the study was to determine the influence of soil flocculant (cationic polyacrylamide (CtPAM)) on the hexavalent chromium ion reduction and accumulation on the kaolinite surface. In this way, the efficiency of the selected polymer conditioner in the soil remediation was determined.

Materials and methods
The adsorbed amounts of Cr(VI) and CtPAM on the kaolinite surface was determined spectrophotometrically (spectrophotometer UV/Vis) using specific indicators. The structure of electrical double layer formed on the kaolinite surface in the mixed system of cationic polyacrylamide and Cr(VI) ions was described based on the adsorptive measurements, zeta potential measurements, as well as potentiometric titration. The kaolinite aggregation in the presence of CtPAM and/or Cr(VI) ions was determined spectrophotometrically and proved using SEM microscopy. The reduction process of Cr(VI) to Cr(III) occurring in the adsorption layer was determined by diffuse reflectance spectroscopy (DRS).

Results and discussion
The obtained results indicated that cationic polyacrylamide contributes to Cr(VI) reduction to Cr(III) form in the kaolinite suspension. This heavy metal ions are strongly adsorbed by the applied clay mineral, especially at pH 5 (then the Cr(VI)-adsorbed amount equals 5.42 mg/g). The CtPAM addition favors the Cr(VI) ion immobilization on the kaolinite surface. In the conditioner presence, the heavy metal-adsorbed amount is even at 7.34 mg/g. The adsorption of CtPAM and chromium(VI) ions induces changes in the kaolinite surface charge density and electrokinetic potential. What is more, both substances favors the kaolinite aggregation.

Conclusions
Cationic polyacrylamide may be considered a substance reducing the toxicity of chromium(VI) ions in the natural environment and decreasing their availability for soil organisms. It can improve the soil structure (by stimulating aggregation) and reduce environment pollution with heavy metals simultaneously.
Electric Arc Length-Voltage and Conductivity Characteristics in a Pilot-Scale AC Electric Arc Furnace
Authors: Pauna H. , Willms T. , Aula M. , Echterhof T. , Huttula M. , Fabritius T. 
Published: June 2020

Abstract
The heat transfer processes and the molten metal bath kinetics of the electric arc furnace are governed by the changes in the arc length and voltage. Thus, information on the electric arc behavior with respect to the voltage is important for accurate computation of the furnace processes and adjustment of the industrial furnace parameters. In this work, the length-voltage characteristics of electric arcs have been studied in a pilot-scale AC electric arc furnace with image analysis, electrical data from the furnace, and slag composition. The arc length was determined with image analysis and the relation between the arc length and voltage from test data. The relation between arc length and voltage was found to be non-linear and dependent on the slag composition. The voltage gradients of the arcs were evaluated as a function of arc length and sum of anode and cathode voltage drops resulting in a reciprocal relation. Furthermore, the electrical conductivity of the arc plasma with respect to arc length was estimated.
The structure of lay-concepts within the fear spectrum revealed using emotional verbal fluency
Authors: Gawda Barbara 
Published: May 2020

AbstractGiven the fact that natural language analysis can distinguish constituents of mental constructs, the present research was designed to investigate the structure of concepts related to the broad spectrum of emotions comprising worry, fear, anxiety, and panic, which in this article is referred to as the ‘fear spectrum’. A new technique presented here is based on a word association task and enables a description of the structure of emotion concepts. The technique is a variant of a verbal fluency task, i.e. emotional verbal fluency technique. Two studies have been conducted: the first to examine the cognitive structure of concepts within thefearspectrum (n = 280, 150 women, 130 men) and the second to confirm the stability of word association in thefeartasks and differentiation of thefearconcepts in relation to trait anxiety and dogmatism (n = 190, 100 women, 90 men). A hierarchical clustering analysis, based on the linguistic material, i.e. words produced by the participants for the task ofanxiety, was performed to present in what way the emotional verbal fluency technique can be applied to explore the structure of emotional concepts. According to our results, there is a relatively constant tendency in producing semantic clusters (emotional word association) among lay people. Moreover, produced clusters allow to describe the structure and to differentiate lay-concepts within thefearspectrum, such asworry, fear, anxiety, panic[respectively in Polish: obawa, lęk, strach, panika].
Conserving genetic resources for agriculture: economic implications of emerging science
Authors: Gollin Douglas 
Published: June 2020

AbstractNew challenges have arrived for the conservation of plant genetic resources for food and agriculture. Increased pressure on the environment, including the added threat of climate change, has had adverse effects on biodiversity and agricultural systems. Emerging science and new technologies have at the same time altered the scope of possibilities for collection, conservation, and utilization of genetic resources for agriculture. Taken together, these changes imply a need for a refocusing of global strategies for the management of genetic resources for agriculture. This paper argues that simple theoretical models provide relatively little guidance for key questions about genebank management. The fundamental uncertainty of scientific possibility and global futures makes it challenging – and perhaps futile – to attempt economic valuation of gene banks. A more useful application of economic tools will be in the prioritization of collection and conservation. Economic analysis may also offer useful insights into the efficient management of genetic resources.
Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response
Authors: Li Mi , Shu Hong-Bing 
Published: May 2020

Abstract
The cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in host defense by sensing cytosolic DNA derived from microbial pathogens or mis-located cellular DNA. Upon DNA binding, cGAS utilizes GTP and ATP as substrates to synthesize cGAMP, leading to MITA-mediated innate immune response. In this study, we identified the phosphatase PPP6C as a negative regulator of cGAS-mediated innate immune response. PPP6C is constitutively associated with cGAS in un-stimulated cells. DNA virus infection causes rapid disassociation of PPP6C from cGAS, resulting in phosphorylation of human cGAS S435 or mouse cGAS S420 in its catalytic pocket. Mutation of this serine residue of cGAS impairs its ability to synthesize cGAMP upon DNA virus infection. In vitro experiments indicate that S420-phosphorylated mcGAS has higher affinity to GTP and enzymatic activity. PPP6C-deficiency promotes innate immune response to DNA virus in various cells. Our findings suggest that PPP6C-mediated dephosphorylation of a catalytic pocket serine residue of cGAS impairs its substrate binding activity and innate immune response, which provides a mechanism for keeping the DNA sensor cGAS inactive in the absence of infection to avoid autoimmune response.
A Review on Nano-/Microstructured Materials Constructed by Electrochemical Technologies for Supercapacitors
Authors: Lv Huizhen , Pan Qing , Song Yu , Liu Xiao-Xia , Liu Tianyu 
Published: May 2020

AbstractThe article reviews the recent progress of electrochemical techniques on synthesizing nano-/microstructures as supercapacitor electrodes. With a history of more than a century, electrochemical techniques have evolved from metal plating since their inception to versatile synthesis tools for electrochemically active materials of diverse morphologies, compositions, and functions. The review begins with tutorials on the operating mechanisms of five commonly used electrochemical techniques, including cyclic voltammetry, potentiostatic deposition, galvanostatic deposition, pulse deposition, and electrophoretic deposition, followed by thorough surveys of the nano-/microstructured materials synthesized electrochemically. Specifically, representative synthesis mechanisms and the state-of-the-art electrochemical performances of exfoliated graphene, conducting polymers, metal oxides, metal sulfides, and their composites are surveyed. The article concludes with summaries of the unique merits, potential challenges, and associated opportunities of electrochemical synthesis techniques for electrode materials in supercapacitors.
Phylogeny of the Eocene Antarctic Tapetinae Gray, 1851 (Bivalvia, Veneridae) from the La Meseta and Submeseta formations
Authors: Alvarez Maximiliano Jorge , del Río Claudia Julia 
Published: June 2020

AbstractSystematic analysis shows that the Southern Hemisphere bivalve genus Retrotapes includes the Antarctic species R. antarcticus, R. newtoni, and R. robustus and recognizes for the first time the presence of Katelysia represented by K. florentinoi. Two new genera were erected in this study: Marciachlys new genus to include M. inflata new combination, and Adelfia new genus, which includes A. austrolissa new combination and A. omega new species from the Eocene of Antarctica, and the late Eocene Chilean A. arenosa new combination. Eurhomalea carlosi was synonymized with K. florentinoi; Cyclorismina marwicki with R. antarcticus; Gomphina iheringi was considered an indeterminate species; and Cockburnia lunulifera was excluded from the Tapetinae. These systematic assignments are supported by a phylogenetic analysis, which recognizes an Austral clade of Tapetinae, comprising all the genera mentioned above, along with Marcia, Paleomarcia, Atamarcia, and Protapes.UUID: http://zoobank.org/a8c91a9f-99ec-4235-8416-d398771a3eb2