bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Alum Sludge and Metakaolin as a Partial Replacement Cement Adding Superplastizer
Authors: Vasudevan Gunalaan 
Published: November 2019

Abstract
The most important activities that improve the economy of Malaysia is the construction industry. Hence it will cause the usage of the concrete increase. When the concrete usage increase, it also increase the cement use because cement is the primary material that forms the concrete and during the production of the cement, it will cause the emission of carbon dioxide which will harm the environment as well as people in Malaysia. After that, alum sludge also caused a lot environment problem because it is lack of potential to be reused in other industry and it needs to be treated before it disposed of, which will cause the financial problem to the government. After the treatment, the economical ways to dispose of it is by using landfill method. But due to a limited landfill site in Malaysia and it is the temporary solution for the disposal of the waste, it becomes a problem to Malaysia and the number of the alum sludge keeping increase year by year because of the population increase year by year too. The purpose of the study is to find out the effectiveness of this combination. The research method that use in this study is by taking out some experiment such as slump test also known as workability test, compressive strength test, flexural strength test, ultrasonic pulse velocity (UPV) test (direct and semi-direct method) and scanning electron microscope (SEM) with the concrete day-age 7, 14 and 28 days. The result gets these test is the 10% alum sludge as a partial replacement for metakaolin in concrete adding superplasticizer (Sika Viscocrete 208) is the best replacement level in term of the workability compressive strength, Flexural strength, speed of the UPV and in scanning electron microscope. After 10% replacement level, the reading all suffer a downturn. Additionally, when the day-age of the concrete increase, the reading will be increase too. This happens to all the replacement level and the 10% replacement level with 28 day-age achieve the highest reading in this study. The contribution and implications of the findings are the using the 10% of the alum sludge as a partial replacement for metakaolin in concrete adding superplasticizer (Sika Viscocrete 208) is the best replacement level compare to others.
Numerical Simulation of Wave Landing Loads Characteristics of Twin-Float Seaplane
Authors: Qi HU , Bin WU , Ming-Zhen Wang , Miao Huang , Rong Jiang 
Published: November 2019

Abstract
The coupled Euler-Lagrangian method is used to simulate the load characteristics of a Twin-Float seaplane when it is landing in waves. The fluid domain is described by Euler, the structure is described by Lagrangian, and the coupling interaction between the Euler material and the Lagrangian element is simulated by the enhanced immersion boundary method. Firstly, a three-dimensional numerical wave tank is established, and the accuracy of numerical wave-making is verified by linear wave theory. Then, the numerical calculation of seaplane wave landing load at different wave heights with the same wave length is carried out, Lastly the numerical results compared with the model experiment of towing tank. The numerical simulation results are in good agreement with the model experiment results. The results show that there will be obvious bouncing phenomena when the seaplane landed in the wave, and the higher the wave height is, the greater the load will be generated when the wave length is the same.
A Multi-Objective Model with Probability Constraints of Trans-Provincial Hydropower Consumption Considering Dynamic Stability Limit
Authors: Yang Ke , Mao Rui , Wen Xu , Gao Chuncheng , Huang Miao , Yan Wei 
Published: November 2019

Abstract
With the rapid development of clean energy and serious delay of grid construction, water abandonment is becoming more and more severe. Under this condition, this paper proposed a multi-objective model with probability constraints of trans-provincial hydropower consumption considering dynamic stability limit. Firstly, a mathematical expression about the dynamic stability limit of trans-provincial channel is constructed. Secondly, a risk assessment index of abandoned water is established on the basis of semi-absolute deviation. Then, based on the framework of stochastic programming, a multi-objective model with probability constraints is proposed for hydropower transmission in trans-provincial trade. By means of genetic algorithm with embedded Monte-Carlo simulation technology, the model can be solved efficiently. Finally, data of Tibet power grid is calculated to verify the validity and universality of the research. The results show that the established model can achieve optimal economic benefit between grid companies and generation enterprises, and also effective management of water abandonment risk.
Design and Evaluation of Scene-Based Product Device
Authors: Wang Yanhua , Yan Dong 
Published: November 2019

Abstract
The production of persimmon has a long history, however, the traditional production of persimmon depends mainly on manpower and is greatly affected by the natural weather. The yield and quality cannot be guaranteed which affects the taste, sales and word of mouth. According to the scenario design program, four kinds of user requirement models are constructed. After systematic analysis, four functional principle schemes are obtained, and five evaluation indexes are summarized. Finally, scheme 4 is selected as the most ideal scheme. Through the research and application of scenario design method in the process of product design, this paper provides an evaluation method for the evaluation of the product design, which helps designers to determine the direction of product development effectively.
Design of High-Efficiency Refrigerator Test System for Industrial Internet of Things
Authors: Xian Lintao , Jing Wei , Yang Chao 
Published: November 2019

Abstract
Smart homes are developing rapidly, and refrigerators are an indispensable part of “smart homes”. Therefore, the research efficiency and quality assurance of refrigerators are highly valued by home appliance companies. Refrigerator test is required in both research and production processes. At present, the quality test of refrigerator has a high degree of manual participation, such as the selection of the stable operating range of refrigerator and the conversion of test stage require manual determination, which cause low test efficiency and high electric energy consumption. In order to solve these problems, this paper design a High-Efficiency Refrigerator Test System (HERTS) for Industrial Internet of Things (IIoT). The core test data intelligent analysis module realizes timely determination of test data and automatic transition of test stage. The proposed HERTS increases the efficiency of automate refrigerator test and greatly reduces the power consumption.
Influence of acoustic treatment and nature of solvents on viscosity of heavy oils
Authors: Volkova G I , Morozova A V 
Published: November 2019

Abstract
The article summarizes experimental data on the influence of acoustic treatment and the nature of solvents on the viscosity of oil from the Timan-Pechora and the Volga-Ural oil and gas-bearing basin. A combined treatment of oils, including acoustic exposure to 22 kHz and the addition of a chemical reagent was carried out. It is shown that the introduction of 1.75% wt alkaline solution of isobutyl alcohol leads to a decrease in oil viscosity of the Timan-Pechora oil and gas-bearing basin by 35%. After complex treatment (acoustic exposure for 1 min and the addition of reagent) the viscosity decreased by 60%. The introduction of alkaline chemicals into the oil of the Volga-Ural oil and gas-bearing basin does not lead to a decrease in viscosity. Oil viscosity decreases by 2.1 times after the introduction of 3% wt solvent P-12 (60% toluene, 10% xylene, 30% butyl acetate). Viscosity reduces by further 18% after acoustic exposure. Thus, the maximum viscosity reduction of heavy oils can be achieved by using the combined treatment including of acoustic exposure and addition of the selected chemical reagent.
Identification of Penicillium species by MALDI-TOF MS analysis of spores collected by dielectrophoresis
Authors: Reeve Michael A , Bachmann Denise , Caine Thelma S 
Published: November 2019

Abstract
In matrix-assisted laser-desorption and ionization mass spectrometry, spectral differences are frequently observed using different growth media on agar plates and/or different growth times in culture, which add undesirable analytical variance. In this article, we explore an approach to the above problem based upon the rationale that, while protein expression in fungal mycelium may well vary under different growth conditions, this might not apply to the same extent in fungal spores. To this end, we have exploited the fact that while mycelium is generally anchored to the fungal-growth substrate, some fungi produce physically-isolated spores which, as such, are amenable to manipulation using dielectrophoresis (the translational motion of charged or uncharged matter caused by polarization effects in a non-uniform electrical field). Such fields can be conveniently generated through the charging of an insulator using the triboelectric effect (the transfer of charge between two objects through friction when they are rubbed together). In this study, polystyrene microbiological inoculating loops were used in combination with nylon-fabric rubbing to harvest fungal spores from five species from within the genus Penicillium, which were grown on agar plates containing two different media over an extended time course. In terms of average Bruker spectral-comparison scores, our method generated higher scores in 80% of cases tested and, in terms of average coefficients of variation, our method generated lower spectral variability in 93% of cases tested. Harvesting of spores using a rapid, inexpensive and simple dielectrophoretic method, therefore, facilitates improved fungal identification for the Penicillium species tested.
Selling Drugs on Darkweb Cryptomarkets: Differentiated Pathways, Risks and Rewards
Authors: Martin James , Munksgaard Rasmus , Coomber Ross , Demant Jakob , Barratt Monica J 
Published: November 2019

AbstractCryptomarkets, anonymous online markets where illicit drugs are exchanged, have operated since 2011, yet there is a dearth of knowledge on why people use these platforms to sell drugs, with only one previous study involving interviews with this novel group. Based on 13 interviews with this hard to reach population, and data analysis critically framed from perspectives of economic calculation, the seductions of crime, and drift and techniques of neutralization, we examine the differentiated motivations for cryptomarket selling. Throughout the interviews, we observe an appreciation for the gentrified norms of cryptomarkets and conclude that cryptomarket sellers are motivated by concerns of risks and material rewards, as well as non-material attractions in a variety of ways that both correspond with, and differ from, existing theories of drug selling.
Abundant Self-Amplifying Intermediate Progenitors in the Subventricular Zone of the Chinese Tree Shrew Neocortex
Authors: Yin Chonghai , Zhou Xin , Yao Yong-Gang , Wang Wei , Wu Qian , Wang Xiaoqun 
Published: November 2019

Abstract
During evolution, neural progenitor cells in the subventricular zone (SVZ) have fundamental functions, ranging from brain volume expansion to the generation of a six-layered neocortex. In lissencephalic animal models, such as rodents, the majority of neural progenitors in the SVZ are intermediate progenitor cells (IPCs). Most IPCs in rodents undergo neurogenic division, and only a small portion of them divide a very limited number of times to generate a few neurons. Meanwhile, in gyrencephalic animals, such as primates, IPCs are able to self-renew for up to five successive divisions. However, abundant IPCs with successive proliferative capacity have not been directly observed in nonprimate species. In this study, we examined the development of neural progenitors in the Chinese tree shrew (Tupaia belangeri chinensis), a lissencephalic animal with closer affinity than rodents to primates. We identified an expansion of the SVZ and the presence of outer radial glial (oRG) cells in the neocortex. We also found that IPCs have the capacity to self-amplify multiple times and therefore serve as major proliferative progenitors. To our knowledge, our study provides the first direct evidence of abundant IPCs with proliferative potential in a nonprimate species, further supporting the key role of IPCs in brain expansion.
Motor and Limbic System Contribution to Emotional Laughter across the Lifespan
Authors: Talami Francesca , Vaudano Anna Elisabetta , Meletti Stefano 
Published: November 2019

AbstractLaughter is a universal human behavior generated by the cooperation of different systems toward the construction of an expressive vocal pattern. Given the sensitivity of neuroimaging techniques to movements, the neural mechanisms underlying laughter expression remain unclear. Herein, we characterized the neural correlates of emotional laughter using the onsets and the duration of laughter bursts to inform functional magnetic resonance imaging. Laughter-related blood oxygen level-dependent (BOLD) increases involved both the motor (motor cortex, supplementary motor area, frontal operculum) and the emotional/limbic (anterior cingulate cortex, amygdala, n. accumbens, hippocampus) systems, as well as modulatory circuitries encompassing the basal ganglia, thalamus, and cerebellum. BOLD changes related to the 2 s preceding the laughter outbreak were selectively observed at the temporo-occipital junction and the periaqueductal gray matter, supporting the role of the former in the detection of incongruity and the gating role of the latter in the initiation of spontaneous laughter. Moreover, developmental changes were identified in laughter processing, consisting in a greater engagement of the reward circuitry in younger subjects; conversely, the default mode network appears more activated in older participants. Our findings contribute valuable information about the processing of real-life humorous materials and suggest a close link between laughter-related motor, affective, and cognitive elements, confirming its complex and multi-faceted nature.
Positive family history of cardiovascular disease and long-term outcomes after coronary artery bypass grafting: a genetic paradox?
Authors: Ruttmann Elfriede , Abfalterer Hannes , Dietl Marion , Wagner Julian , Kilo Juliane , Grimm Michael , Bates Katie , Fritz Josef , Ulmer Hanno 
Published: November 2019

Abstract

OBJECTIVES
Parental cardiovascular disease (CVD) is a known risk factor for premature CVD. It is unknown whether a positive family history (PFH) affects outcomes after coronary artery bypass grafting (CABG).

METHODS
Data come from a retrospective longitudinal study of CABG patients consecutively recruited from 2001 to 2018 (n = 5389). From this study, 2535 patients with premature CVD undergoing CABG under the age of 60 years and information on parental CVD were identified. The Framingham offspring study criteria were used to identify PFH of CVD. Multivariable Cox proportional hazards regression models were used to assess the effect of PFH on overall and major adverse cardiovascular and cerebrovascular event-free survival.

RESULTS
A total of 273 deaths and 428 major adverse cardiovascular and cerebrovascular events occurred during follow-up. PFH of CVD was found in 54.2% of patients (n = 1375). Within these patients, 66.1% had a father who experienced a premature cardiovascular event (n = 909), 27.8% a mother (n = 382) and 6.1% both a mother and a father (n = 84). In the majority of cases, the patient’s parent had experienced a cardiac event (85.9%, n = 1181) and 14.1% of patients with PFH reported parental stroke (n = 194). Following CABG, PFH was associated with improved overall [adjusted hazards ratio (HR) 0.67, 95% confidence interval (CI) 0.50–0.90; P = 0.008] and major adverse cardiovascular and cerebrovascular event-free survival (adjusted HR 0.73, 95% CI 0.68–0.89; P = 0.01). Among the covariates adjusted for age, diabetes, renal insufficiency, peripheral arterial disease, ejection fraction, previous cerebrovascular events and previous mediastinal radiation were all associated with poorer outcomes.

CONCLUSIONS
Although it is well established that a PFH increases the risk of requiring CABG at younger ages, this study shows that, paradoxically, PFH is also protective regarding long-term outcomes.

Registration number local IRB
UN4232 297/4.3 (retrospective study).
Cardiovascular abnormalities in patient with Williams–Beuren syndrome
Authors: Panfilov Dmitry S , Saushkin Viktor V , Kozlov Boris N 
Published: November 2019

Abstract
We present a case of a 42-year-old male patient with severe supravalvular aortic stenosis associated with aortic and mitral valve stenosis as well as an anomalous origin of the right coronary ostium caused by deletion in the q11.23 region of the human chromosome 7 in a patient with Williams–Beuren syndrome.
The O-GalNAcylating enzyme GALNT5 mediates carcinogenesis and progression of cholangiocarcinoma via activation of AKT/ERK signaling
Authors: Detarya Marutpong , Sawanyawisuth Kanlayanee , Aphivatanasiri Chaiwat , Chuangchaiya Sriwipa , Saranaruk Paksiree , Sukprasert Lukkana , Silsirivanit Atit , Araki Norie , Wongkham Sopit , Wongkham Chaisiri 
Published: November 2019

AbstractMucin type O-glycosylation is a posttranslational modification of membrane and secretory proteins. Transferring of N-acetylgalactosamine, the first sugar of O-glycosylation, is catalyzed by one of the 20 isoforms of polypeptide N-acetylgalactosaminyltransferases (GALNTs). In this study, Vicia villosa lectin (VVL), a lectin that recognizes O-GalNAcylated glycans, was used to detect VVL-binding glycans (VBGs) in cholangiocarcinoma (CCA). The elevation of VBGs in tumor tissues of the liver fluke associated with CCA from hamsters and patients was noted. VBGs were detected in hyperplastic/dysplastic bile ducts and CCA but not in normal biliary epithelia and hepatocytes, indicating the association of VBGs with CCA development and progression. GALNT5 was shown to be the major isoform found in human CCA cell lines with high VBG expression. Suppression of GALNT5 expression using siRNA significantly reduced VBG expression, signifying the connection of GALNT5 and VBGs observed. Knocked-down GALNT5 expression considerably inhibited proliferation, migration and invasion of CCA cells. Increased expression of GALNT5 using pcDNA3.1-GALNT5 expression vector induced invasive phenotypes in CCA cells with low GALNT5 expression. Increasing of claudin-1 and decreasing of slug and vimentin expression together with inactivation of Akt/Erk signaling were noted in GALNT5 knocked-down cells. These observations were reversed in GALNT5 over-expressing cells. GALNT5-modulated progression of CCA cells was shown to be, in part, via GALNT5-mediated autocrine/paracrine factors that stimulated activations of Akt/Erk signaling and the epithelial to mesenchymal transition process. GALNT5 and its O-GalNAcylated products may have important roles in promoting progression of CCA and could possibly be novel targets for treatment of metastatic CCA.
A CCR4 Association Factor 1, OsCAF1B, Participates in the αAmy3 mRNA Poly(A) Tail Shortening and Plays a Role in Germination and Seedling Growth
Authors: Fang Jhen-Cheng , Liu Hsin-Yi , Tsai Yin-Chuan , Chou Wei-Lun , Chang Chun-Chen , Lu Chung-An 
Published: November 2019

AbstractPoly(A) tail (PAT) shortening, also termed deadenylation, is the rate-limiting step of mRNA degradation in eukaryotic cells. The carbon catabolite repressor 4-associated factor 1s (CAF1s) were shown to be one of the major enzymes for catalyzing mRNA deadenylation in yeast and mammalian cells. However, the functions of CAF1 proteins in plants are poorly understood. Herein, a sugar-upregulated CAF1 gene, OsCAF1B, is investigated in rice. Using gain–of–function and dominant-negative mutation analysis, we show that overexpression of OsCAF1B resulted in an accelerated α-amylase gene (αAmy3) mRNA degradation phenomenon, while ectopic expression of a form of OsCAF1B that had lost its deadenylase activity resulted in a delayed αAmy3 mRNA degradation phenomenon in transgenic rice cells. The change in αAmy3 mRNA degradation in transgenic rice is associated with the altered lengths of the αAmy3 mRNA PAT, indicating that OsCAF1B acts as a negative regulator of αAmy3 mRNA stability in rice. Additionally, we found that overexpression of OsCAF1B retards seed germination and seedling growth. These findings indicate that OsCAF1B participates in sugar-induced αAmy3 mRNA degradation and deadenylation and acts a negative factor for germination and seedling development.
High bone microarchitecture, strength, and resistance to bone loss in MRL/MpJ mice correlates with activation of different signaling pathways and systemic factors
Authors: Sun Xuying , Gao Xueqin , Deng Zhenhan , Zhang Linlin , McGilvray Kirk , Gadomski Benjamin C. , Amra Sarah , Bao Gang , Huard Johnny 
Published: November 2019

AbstractThe MRL/MpJ mice have demonstrated an enhanced tissue regeneration capacity for various tissues. In the present study, we systematically characterized bone microarchitecture and found that MRL/MpJ mice exhibit higher bone microarchitecture and strength compared to both C57BL/10J and C57BL/6J WT mice at 2, 4, and 10 months of age. The higher bone mass in MRL/MpJ mice was correlated to increased osteoblasts, decreased osteoclasts, higher cell proliferation, and bone formation, and enhanced pSMAD5 signaling earlier during postnatal development (2‐month old) in the spine trabecular bone, and lower bone resorption rate at later age. Furthermore, these mice exhibit accelerated fracture healing via enhanced pSMAD5, pAKT and p‐P38MAPK pathways compared to control groups. Moreover, MRL/MpJ mice demonstrated resistance to ovariectomy‐induced bone loss as evidenced by maintaining higher bone volume/tissue volume (BV/TV) and lower percentage of bone loss later after ovariectomy. The consistently higher serum IGF1 level and lower RANKL level in MRL/MpJ mice may contribute to the maintenance of high bone mass in uninjured and injured bone. In conclusion, our results indicate that enhanced pSMAD5, pAKT, and p‐P38MAPK signaling, higher serum IGF‐1, and lower RANKL level contribute to the higher bone microarchitecture and strength, accelerated healing, and resistance to osteoporosis in MRL/MpJ mice.