bluuebunny/crossref_metadata_2025_split huggingface dataset:
Конструктивні системи висотних будівель
Authors: Pershakov Valeriy , Bieliatynskyi Andrii , Bilyk Sergiy , Bakulin Yevgen , Pylypenko Oleksandr , Bolotov Georgiy , Akmaldinova Oleksandra , Martynenko Ivanna , Reznyk Oleksandr 
Published: May 2020

Стаття присвячена актуальним питанням дослідження конструктивної системи висотних будівель, яка утворює архітектурний образ і об’ємно-просторову структуру, що складається із сукупності взаємозв’язаних конструктивних елементів, які при сумісній роботі забезпечують міцність просторової структури, просторову жорсткість і загальну стійкість об’єкта. У висотних будівлях застосовують різні конструктивні схеми, які складаються із вертикальних (колон, стін, ядер, діафрагм та інші) і горизонтальних елементів (перекриттів, покриттів, балок, розкісних поясів та інших). Горизонтальні несучі конструкції висотних будівель, як правило, однотипні і зазвичай являють собою жорсткий залізобетонний диск (монолітний, збірно-монолітний, збірний). Горизонтальні конструкції сприймають вертикальні та горизонтальні навантаження і передають їх на несучі конструкції та на фундаменти. З метою зниження вітрових впливів вибирають ефективну в аеродинамічному відношенні циліндричну, пірамідальну або призматичну форму будівлі. Конструкції висотних будинків мають свою специфіку, яка значною мірою впливає на їхні об’ємна-планувальні та архітектурно-конструктивні рішення. До таких особливостей відносяться: значні навантаження на несучі конструкції; неоднакове навантаження на конструктивні елементи конструкцій; високе значення вітрового навантаження як горизонтальної складової; проблеми спільної роботи несучих конструкцій із сталі та бетону; вплив природних факторів (сейсмічних, атмосферних, аеродинамічних); вплив техногенних факторів (вібрації, шуми, аварії, пожежі, диверсійні акти, локальні руйнування);підвищені вимоги до пожежної безпеки та систем життєзабезпечення; складне інженерно-технічне забезпечення.
La historia de las palabras relacionadas con la anatomía del aparato genital femenino
Authors: Alarcón Nivia Miguel Angel 
Published: May 2020

Se hace mención a la historia de las principales palabras que describen la anatomía del aparato genital femenino buscando su nacimiento en la mitología, en la historia de la medicina, en la filología y en las raíces etimológicas del latín, el griego y lenguas afines.
Tempos e ventos da educação comparada [Entrevista]
Authors: Gomes Candido Alberto 
Published: May 2020

Na América Latina, econômica e culturalmente introvertida, a educação comparada nos anos 1980 era como uma janela aberta. Vários Estados não eram democráticos de Direito, o que a tornou até certo ponto arriscada, conforme teorias e metodologias...
Comparison of Irisin Serum Healthy Untrained Males on Treadmill Exercises by Increasing Gradually Speed Vs Inclination
Authors: B Uda'a , D Tinduh , HR Masduchi , H Laswati , S Wibisono , Soenatalina Soenatalina , S Theodora 
Published: May 2020

Aerobic exercise can improve cardiorespiratory fitness in young people. Irises released into the bloodstream function to execute regulation of energy metabolism, triggering browning white adipose, which is useful in mitochondrial biogenesis. The American College of Sport Medicine (ACSM) recommends moderate intensity cardiorespiratory fitness training with a frequency of 3-5 times a week, duration of 20-60 minutes, using a treadmill. Study subjects (n = 20) were divided randomly into 2 groups, namely the moderate intensity Treadmill training group with gradual speed improvement and gradual inclination increase. Serum slices are measured on the first and last day of exercise. There was an increasing of irisin serum in the moderate intensity Treadmill training group by increasing gradually speed after 2 weeks of exercise, both 30 minutes pre-exercise (p = 0.02) and 1 hour post exercise (p = 0.01). Medium intensity Treadmill training with 2 weeks gradual speed increase with frequency 3 times a week can increase serum slice in men, healthy untrained young men.
Identification of novel alternative splicing isoform biomarkers and their association with overall survival in colorectal cancer
Authors: Lian Haifeng , Wang Aili , Shen Yuanyuan , Wang Qian , Zhou Zhenru , Zhang Ranran , Li Kun , Liu Chengxia , Jia Hongtao 
Published: May 2020

Abstract
Background: Alternative splicing (AS) is an important mechanism of regulating eukaryotic gene expression. Understanding the most common AS events in colorectal cancer (CRC) will help developing diagnostic, prognostic or therapeutic tools in CRC.Methods: Publicly available RNA-seq data of 28 pairs of CRC and normal tissues and 18 pairs of metastatic and normal tissues were used to identify AS events using PSI and DEXSeq methods. Result: The highly significant splicing events were used to search a database of The Cancer Genome Atlas (TCGA). We identified AS events in 9 genes in CRC (more inclusion of CLK1-E4, COL6A3-E6, CD44v8-10, alternative first exon regulation of ARHGEF9, CHEK1, HKDC1 and HNF4A) or metastasis (decrease of SERPINA1-E1a, CALD-E5b, E6). Except for CHEK1, all other 8 splicing events were confirmed by TCGA data with 382 CRC tumors and 51 normal controls. The combination of three splicing events was used to build a logistic regression model that can predict sample type (CRC or normal) with near perfect performance (AUC=1). Two splicing events (COL6A3 and HKDC1) were found to be significantly associated with patient overall survival. The AS features of the 9 genes are highly consistent with previous reports and/or relevant to cancer biology. Conclusions: The significant association of higher expression of the COL6A3 E5-E6 junction and HKDC1 E1-E2 with better overall survival was firstly reported. This study might be of significant value in the future biomarker, prognosis marker and therapeutics development of CRC.
Detection of water-molecular-motion configuration in patients with lupus nephritis: A primary study using diffusion-weighted imaging.
Authors: Wang Yanyan , Shi Huilan , Yan Tiekun , Jia Junya , Li Dong , Wei Li , Shang Wenya , zheng zhenfeng 
Published: May 2020

Abstract
Background: Lupus nephritis (LN) is one of most common types of secondary glomerulonephritis, which is characterized by longitudinal pathological changes. Microstructural lesions of LN will impact the motion of water molecules, which can be detected by diffusion-weighted imaging (DWI). There are few reported measurements of water diffusion in patients with LN, and the nature of water diffusion across the entire depth of the renal parenchyma remains largely unknown.Methods: Twenty adult patients with LN and 11 healthy volunteers underwent DWI inspection. Renal biopsy samples were characterized based on the revised ISN/RPS 2003 classification. The apparent-diffusion coefficient (ADC) was calculated via fitting into a mono-exponential model. To compare the ADC level across the entire renal parenchyma between the two groups, repeated-measures analysis of variance (RM-ANOVA) was performed. ADC data derived from DWI pictures were transformed into tridimensional maps by MATLAB software.Results: Compared with data from healthy volunteers, lower average ADC values with major undulatory magnitudes were found in patients with LN, especially in the cortical zone. Tridimensional maps of patients with LN displayed geographic terrain-like canyons and/or valleys that were different from the corresponding terrain-like flatlands and/or plateaus in healthy volunteers. A heterogeneity of ADC values was found in bilateral kidneys. Left kidneys predominated higher ADC values in patients with LN. The ADC values across the entire renal parenchyma exhibited statistically significant differences among the three identified pathological subclasses (P<0.001).Conclusions: Analysis of the motion of water molecules across the entire renal parenchyma may be helpful for better understanding the pathological conditions of LN, for which microstructural and functional heterogeneity may be detected and visualized via DWI.
Antiseptics as Adjuncts to Scaling and Root Planing in the Treatment of Periodontitis: A Systematic Literature Review
Authors: Ramanauskaite Egle , Machiulskiene Vita 
Published: May 2020

Abstract
Background : Periodontitis is microbially-associated, host-mediated inflammatory condition that results in loss of periodontal attachment. The goals of periodontal therapy include arresting the disease progression, establishing healthy, stable, maintainable periodontal conditions. A fundamental strategy of treating periodontitis is scaling and root planning (SRP), however its efficacy may be restricted in areas inaccessible for mechanical instrumentation. As periodontitis is infectious in nature, it might be helpful to use additional antimicrobial adjuncts, in order to eliminate or inactivate pathogenic microflora. The aim of this study is to evaluate the current evidence regarding the potential clinical benefits of using additional antiseptics for SRP in nonsurgical periodontal therapy. Methods: An electronic literature search was conducted in the MEDLINE (Ovid) and Cohrane Central Register of Controlled Trials (CENTRAL) databases for articles published between January 1, 2000 and September 22, 2019. Randomized controlled clinical trials in English that compare the effectiveness of one or more antiseptic agents as adjuncts to SRP with a follow-up of ≥ 6 months were included. A meta-analysis using the random-effects model was performed on the selected qualifying articles. Results: The search resulted in 12 articles that met the inclusion criteria. Based on the vehicle employed to deliver the antiseptic agent, studies were divided into adjunctive sustained-release antiseptics (gels, chips and varnish) and adjunctive irrigation with antiseptics. The meta-analysis demonstrated significant improvements in probing depth (PD) reduction (p = 0.001), clinical attachment level (CAL) gain (p = 0.001), and bleeding on probing (BOP) values (p = 0.001) following the adjunctive subgingival application of sustained-release antiseptics. Additional subgingival irrigation with antiseptics failed to show significant improvements in PD (p = 0.321), CAL (p = 0.7568), or BOP values (p = 0.3549) over SRP alone. Conclusions: Adjunctive subgingivally delivered antiseptics with a sustained-release delivery have significant clinical benefits compared to SRP alone.
Aberrant Functional Connectivity in Resting State Networks of ADHD Patients Revealed by Independent Component Analysis
Authors: Zhang Huayu , Zhao Yue , Cao Weifang , Cui Dong , Jiao Qing , Lu Weizhao , Li Hongyu , Qiu Jianfeng 
Published: May 2020

Abstract
Background: ADHD is one of the most common psychiatric disorders in children and adolescents. Altered functional connectivity has been associated with ADHD symptoms. This study aimed to investigate abnormal changes in the functional connectivity of resting-state brain networks (RSNs) among adolescent patients with different subtypes of ADHD. Methods: The data were obtained from the ADHD-200 Global Competition, including fMRI data from 88 ADHD patients (56 patients of ADHD-Combined, ADHD-C and 32 patients of ADHD-Inattentive, ADHD-I) and 67 typically developing controls (TD-C). Group ICA was utilized to research aberrant brain functional connectivity within the different subtypes of ADHD. Results: In comparison with the TD-C group, the ADHD-C group showed clusters of decreased functional connectivity in the left inferior occipital gyrus (p = 0.0041) and right superior occipital gyrus (p = 0.0011) of the dorsal attention network (DAN), supplementary motor area (p = 0.0036) of the executive control network (ECN), left supramarginal gyrus (p = 0.0081) of the salience network (SN), middle temporal gyrus (p = 0.0041), and superior medial frontal gyrus (p = 0.0055) of the default mode network (DMN), while the ADHD-I group showed decreased functional connectivity in the right superior parietal gyrus (p = 0.0017) of the DAN and left middle temporal gyrus (p = 0.0105) of the DMN. In comparison with the ADHD-I group, the ADHD-C group showed decreased functional connectivity in the superior temporal gyrus (p = 0.0062) of the AN, inferior temporal gyrus (p = 0.0016) of the DAN, and the dorsolateral superior frontal gyrus (p = 0.0082) of the DMN. All the clusters surviving at p < 0.05 (AlphaSim correction). Conclusion: The results suggested that decreased functional connectivity within the DMN and DAN was responsible, at least in part, for the symptom of inattention in ADHD-I patients. Similarly, we believed that the impaired functional connectivity within networks may contribute to the manifestations of ADHD-C patients, including inattention, hyperactivity/impulsivity, and unconscious movements.
lncRNA_Mdeep: an alignment-free predictor for long non-coding RNAs identification by multimodal deep learning
Authors: Fan Xiao-Nan , Zhang Shao-Wu , Zhang Song-Yao , Ni Jin-Jie 
Published: May 2020

AbstractBackground: Long non-coding RNAs (lncRNAs) play crucial roles in diverse biological processes and human complex diseases. Distinguishing lncRNAs from protein-coding transcripts is a fundamental step for analyzing lncRNA functional mechanism. However, the experimental identification of lncRNAs is expensive and time-consuming.Results: In this study, we present an alignment-free multimodal deep learning framework (namely lncRNA_Mdeep) to distinguish lncRNAs from protein-coding transcripts. LncRNA_Mdeep incorporates three different input modalities (i.e. OFH modality, k-mer modality, and sequence modality), then a multimodal deep learning framework is built for learning the high-level abstract representations and predicting the probability whether a transcript is lncRNA or not.Conclusions: LncRNA_Mdeep achieves 98.73% prediction accuracy in 10-fold cross-validation test on human. Compared with other eight state-of-the-art methods, lncRNA_Mdeep shows 93.12% prediction accuracy independent test on human, which is 0.94%~15.41% higher than that of other eight methods. In addition, the results on 11 cross-species datasets show that lncRNA_Mdeep is a powerful predictor for identifying lncRNAs. The source code can be downloaded from https://github.com/NWPU-903PR/lncRNA_Mdeep.
Factors influencing sedentary behaviours after stroke: findings from qualitative observations and interviews with stroke survivors and their caregivers
Authors: Hall Jennifer , Morton Sarah , Fitzsimons Claire F , Hall Jessica Faye , Corepal Rekesh , English Coralie , Forster Anne , Lawton Rebecca , Patel Anita , Mead Gillian , Clarke David J 
Published: May 2020

Abstract
Background: Stroke survivors are more sedentary than healthy, age-matched controls, independent of functional capacity. Interventions are needed to encourage a reduction in overall sedentary time, and regular breaks in prolonged periods of sedentary behaviour. This study captured the views and experiences of stroke survivors and their caregivers related to sedentary behaviour after stroke, to inform the development of an intervention to reduce sedentary behaviour.Methods: Mixed-methods qualitative study. Non-participant observations were completed in two stroke services, inclusive of inpatient and community settings in the United Kingdom. Semi-structured interviews were conducted with stroke survivors and their caregivers (if available) at six- or nine-months post-stroke. Underpinned by the capability, opportunity and motivation (COM-B) model of behaviour change, observational data (132 hours) were analysed thematically and interview data (n=31 stroke survivors, n=12 caregivers) were analysed using the Framework approach.Findings: Observation participants differed in functional ability whereas stroke survivor interviewees were all ambulant. Six themes related to sedentary behaviour after stroke were generated: (1) sedentary behaviour levels and patterns after stroke; (2) the physical and social environment in the stroke service and in the home; (3) standing and movement capability after stroke; (4) emotion and motivation after stroke; (5) caregivers’ influence on, and role in influencing stroke survivors’ sedentary behaviour; and (6) intervening to reduce sedentary behaviour after stroke. Capability, opportunity and motivation were influenced by the impact of the stroke and caregivers’ inclination to support sedentary behaviour reduction. Stroke survivors reported being more sedentary than they were pre-stroke due to impaired balance and co-ordination, increased fatigue, and reduced confidence in mobilising. Caregivers inclination to support stroke survivors to reduce sedentary behaviour depended on factors including their willingness to withdraw from the caregiver role, and their perception of whether the stroke survivor would act on their encouragement. Conclusions: Many stroke survivors indicate being open to reducing sedentary behaviour, with appropriate support from stroke service staff and caregivers. The findings from this study have contributed to an intervention development process using the Behaviour Change Wheel (BCW) approach to develop strategies to reduce sedentary behaviour after stroke.
Eimeria tenella Eimeria-specific protein that interacts with apical membrane antigen 1 (EtAMA1) is involved in host cell invasion
Authors: Li Cong , Zhao Qiping , Zhu Shunhai , Wang Qingjie , Wang Haixia , Yu Shuilan , Yu Yu , Liang Shashan , Zhao Huanzhi , Huang Bing , Dong Hui , Han Hongyu 
Published: May 2020

Abstract
Background: Avian coccidiosis is a widespread, economically significant disease of poultry, caused by several species of the protozoan parasite Eimeria. Among these species, E. tenella causes hemorrhagic pathologies and high mortality. These parasites have complex and diverse lifestyles that require the invasion of their host cells. This is mediated by various proteins secreted from apical secretory organelles. Apical membrane antigen 1 (AMA1), which is released from micronemes and is conserved across all apicomplexans, plays a central role in the host cell invasion. In a previous study, some putative EtAMA1-interacting proteins of E. tenella were screened. In this study, we characterized one putative EtAMA1-interacting protein, E. tenella Eimeria -specific protein (EtEsp).Methods: Bimolecular fluorescence complementation (BiFC) and glutathione S-transferase (GST) fusion protein pull-down (GST pull-down) were used to confirm the interaction between EtAMA1 and EtEsp in vivo and in vitro. The expression of EtEsp was analyzed in different developmental stages of E. tenella with quantitative PCR and western blotting. The secretion of EtEsp protein was tested with staurosporine when sporozoites were incubated in complete medium at 41 °C.The localization of EtEsp was analyzed with an immunoﬂuorescence assay. An in vitro invasion inhibition assay was conducted to assess the ability of antibodies against EtEsp to inhibit cell invasion by E. tenella sporozoites.Results: The interaction between EtAMA1 and EtEsp was confirmed with BiFC in vivo and by GST pull-down in vitro. Our results show that EtEsp is differentially expressed during distinct phases of the parasite life cycle. An immunoﬂuorescence analysis showed that the EtEsp protein is mainly distributed on the parasite surface, and that the expression of this protein increases during the development of the parasite in the host cells. Using staurosporine, we showed that EtEsp is a secreted protein, but not from micronemes. In inhibition tests, a polyclonal anti-rEtEsp antibody attenuated the capacity of E. tenella to invade host cells in vitro. Conclusion: In this study, we show that EtEsp interacts with EtAMA1 and that the protein is secreted protein, but not from micronemes. The protein participates in the sporozoite invasion of host cells and maybe involved in the growth of the parasite in the host. These data have implications for the use of EtAMA1 or EtAMA1-interacting proteins as targets in intervention strategies against avian coccidiosis.
Are one-year changes in adherence to the 24-hour Movement Guidelines associated with depressive symptoms among youth?
Authors: Patte Karen A , Faulkner Guy , Qian Wei , Duncan Markus , Leatherdale Scott T. 
Published: May 2020

Abstract
Background: There remains a need for prospective research examining movement behaviours in the prevention and management of mental illness. This study examined whether changes in adherence to the 24-hour Movement Guidelines (moderate-to-vigorous physical activity [MVPA], sleep duration, screen time) were associated with depression symptoms among youth.Methods: Conditional change models were used to analyze two waves of longitudinal questionnaire data (2016/17, 2017/18) from students in grades 9-12 (N=2292) attending 12 schools in Ontario and British Columbia, Canada, as part of the COMPASS study. One-year change in adherence to the MVPA, screen time, and sleep duration guidelines were modeled as predictors of depressive symptoms, adjusting for covariates and prior year depressive symptoms. Models were stratified by sex.Results: Continued adherence to sleep guidelines and transitioning from inadequate to sufficient sleep were associated with lower depressive symptoms than continued nonadherence, and continued adherence was associated with lower depression than transitioning from sufficient to short sleep. For screen time, transitioning from exceeding guidelines to guideline adherence was associated with lower depressive symptoms than continued nonadherence. MVPA guideline adherence was not associated with depression scores, when controlling for sleep and screen time guideline adherence change and covariates. When combined, meeting additional guidelines than the year prior was associated with lower depressive symptoms among females only.Conclusions: Adherence to the sleep guidelines emerged as the most consistent predictor of depression symptoms. Promoting adherence to the Movement Guidelines, particularly sleep, should be considered priorities for youth mental health at a population level.
Effects of Bodybuilding Supplements on the Kidney: A Population-Based Incidence Study of Biopsy Pathology and Clinical Characteristics among Middle Eastern Men
Authors: Ali Alaa Abbas , Almukhtar Safaa E , Sharif Dana A , Saleem Zana Sidiq M , Muhealdeen Dana N , Hughson Michael D 
Published: May 2020

Abstract
Background: The incidence of kidney diseases among bodybuilders is unknown. Methods: Between January 2011 and December 2019, the Iraqi Kurdistan 15 to 39 year old male population averaged 1,100,000 with approximately 56,000 total participants and 25,000 regular participants (those training more than one year). Annual age specific incidence rates (ASIR) with (95% confidence intervals) per 100,000 bodybuilders were compared with the general age-matched male population. Results: Fifteen male participants had kidney biopsies. Among regular participants, diagnoses were: focal segmental glomerulosclerosis (FSGS), 2; membranous glomerulonephritis (MGN), 2; post-infectious glomeruonephritis (PIGN), 1; tubulointerstitial nephritis (TIN), 1; and nephrocalcinosis , 2. Acute tubular necrosis (ATN) was diagnosed in 5 regular participants and 2 participants training less than one year. Among regular participants, anabolic steroid use was self-reported in 26% and veterinary grade vitamin D injections in 2.6%. ASIR for FSGS, MGN, PIGN, and TIN among regular participants was not statistically different than the general population. ASIR of FSGS adjusted for anabolic steroid use was 3.4 (-1.3 to 8.1), a rate overlapping with FSGS in the general population at 2.0 (1.2 to 2.8). ATN presented as exertional muscle injury with myoglobinuria among new participants. Nevertheless, ASIR for ATN among total participants at 1.4 (0.4 to 2.4) was not significantly different than for the general population at 0.3 (0.1 to 0.5). Nephrocalcinosis was only diagnosed among bodybuilders at a 9-year cumulative rate of one per 314 vitamin D injectors. Conclusions: Kidney disease rates among bodybuilders were not significantly different than for the general population, except for nephrocalcinosis that was caused by injections of veterinary grade vitamin D compounds.