bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical profile and outcome of patients with chronic inflammatory arthritis and metabolic syndrome
Authors: Cioffi Giovanni , Viapiana Ombretta , Tarantini Luigi , Orsolini Giovanni , Idolazzi Luca , Sonographer Federica Ognibeni , Dalbeni Andrea , Gatti Davide , Fassio Angelo , Rossini Maurizio , Giollo Alessandro 
Published: October 2020

AbstractSystemic chronic inflammation may favor the onset of metabolic syndrome (MetS) which represents a risk factor for CV events. Rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are disorders with high prevalence of MetS. We assessed the factors associated with MetS and its prognostic role in non-selected RA/AS/PsA patients. Between March 2014 and April 2016, 458 patients (228 RA, 134 PsA, 96 AS) selected for a primary prevention program for cardiovascular diseases were analyzed. Primary and co-primary end points were a composite of all-cause death/all-cause hospitalization and CV death/CV hospitalization, respectively. MetS was diagnosed according to the IDF Task Force on Epidemiology and Prevention. Patients were divided into MetS + (73 = 16%) and MetS − (385 = 84%). At multivariate logistic analysis, cancer, moderate/high disease activity, higher LV mass (LVM) and degree of LV diastolic dysfunction were independently associated with MetS. At 36-month follow-up, the event rate for primary/co-primary end point was 52/15% in MetS + vs 23/7% in MetS − (both p < 0.001). At multivariate Cox regression analysis, MetS was related to primary end point (HR 1.52 [CI 1.01–2.47], p = 0.04) together with higher LVM, disease duration and higher prevalence of biologic DMARDs refractoriness, and to co-primary end point (HR 2.05 [CI 1.16–3.60], p = 0.01) together with older age and higher LVM. The RA/AS/PsA phenotype MetS + is a subject with moderate/high disease activity, LV structural and functional abnormalities at increased risk for cancer. MetS + identifies RA/AS/PsA patients at higher risk for CV and non-CV events, independently of traditional CV risk factors analyzed individually and traditional indexes of inflammation.
The Peptidyl-prolyl Isomerase Pin1 in Neuronal Signaling: from Neurodevelopment to Neurodegeneration
Authors: Fagiani Francesca , Govoni Stefano , Racchi Marco , Lanni Cristina 
Published: October 2020

AbstractThe peptidyl-prolyl isomerase Pin1 is a unique enzyme catalyzing the isomerization of the peptide bond between phosphorylated serine-proline or threonine-proline motifs in proteins, thereby regulating a wide spectrum of protein functions, including folding, intracellular signaling, transcription, cell cycle progression, and apoptosis. Pin1 has been reported to act as a key molecular switch inducing cell-type-specific effects, critically depending on the different phosphorylation patterns of its targets within different biological contexts. While its implication in proliferating cells, and, in particular, in the field of cancer, has been widely characterized, less is known about Pin1 biological functions in terminally differentiated and post-mitotic neurons. Notably, Pin1 is widely expressed in the central and peripheral nervous system, where it regulates a variety of neuronal processes, including neuronal development, apoptosis, and synaptic activity. However, despite studies reporting the interaction of Pin1 with neuronal substrates or its involvement in specific signaling pathways, a more comprehensive understanding of its biological functions at neuronal level is still lacking. Besides its implication in physiological processes, a growing body of evidence suggests the crucial involvement of Pin1 in aging and age-related and neurodegenerative diseases, including Alzheimer’s disease, Parkinson disease, frontotemporal dementias, Huntington disease, and amyotrophic lateral sclerosis, where it mediates profoundly different effects, ranging from neuroprotective to neurotoxic. Therefore, a more detailed understanding of Pin1 neuronal functions may provide relevant information on the consequences of Pin1 deregulation in age-related and neurodegenerative disorders.
Cytoreductive surgery and HIPEC in colorectal cancer—did we get hold of the wrong end of the stick?
Authors: Yurttas Can , Fisher Oliver M. , Cortés-Guiral Delia , Haen Sebastian P. , Königsrainer Ingmar , Königsrainer Alfred , Beckert Stefan , Liauw Winston , Löffler Markus W. 
Published: October 2020

SummaryCytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are a multimodal treatment approach combining surgical interventions of varying extent with administration of heated cytostatic drugs flushed through the abdominal cavity. Hitherto, this treatment has been popular for peritoneal metastasis (PM), e.g. from colorectal cancer (CRC). Recent randomized controlled trials (RCT) question the benefit of HIPEC in its present form for CRC treatment and raise fundamental issues, eliciting discussions and expert statements regarding HIPEC relevance and interpretation of these results. Unfortunately, such discussions have to remain uninformed, due to the lacking publication of crucial peer reviewed RCT results. Novel basic research aware of HIPEC futility suggests there may be systematic limitations. Innovative modelling approaches for HIPEC may shed light on the reasons for therapeutic failure of frequently used drugs and may lead the way to select better alternatives and/or more rational approaches for the design of HIPEC procedures (e.g. regarding exposure time or temperature). Available evidence strongly supports the notion that CRS is the mainstay for the treatment effects observed in PM from CRC. Unfortunately, HIPEC has become a surrogate for surgical expertise in the field and optimal surgery may therefore outweigh the potentially harmful effects of HIPEC treatment, particularly in lieu of modern systemic chemotherapies. The current situation which frequently is assumed to be deadlocked should be regarded as a challenge to investigate HIPEC with well-designed prospective clinical trials, potentially even constituting an opportunity for introducing innovative trial designs that solve the multifaceted issues of a very heterogeneous treatment approach.
Professional Development Track to Prepare Future Academic Clinicians
Authors: Traylor K. Marie , Cervantes Jorge L. , Perry Cynthia N. 
Published: October 2020

AbstractProfessional development is instrumental in the success of professionals and trainees in academic medicine. In response to medical student feedback requesting additional professional development opportunities, the Foster School of Medicine developed a distinction program, the Pathway for Preparing Academic Clinicians (PPAC), designed to deliver sought-after skill development and foundational knowledge in the three primary activities of academic medicine: medical education, research, and patient care. This distinction program addresses a curricular gap as identified by students and common to many UME curricula and also provides an opportunity for residency programs to identify student achievement within a pass/fail program.
The Off-Axis IBII Test for Composites
Authors: Parry S. , Fletcher L. , Pierron F. 
Published: October 2020

AbstractComposite components regularly experience dynamic loads in service. Despite this, it is still difficult to obtain accurate mechanical properties of composite materials under high strain rate conditions. In this study, a new application of the Image-Based Inertial Impact (IBII) test methodology was developed, to generate an accurate in-plane transverse and shear moduli dataset from unidirectional (UD) off-axis composite specimens. The obtained dataset was consistent across different sample configurations, where results from the UD45$$^{\circ }$$∘off-axis specimens agreed well with the UD90$$^{\circ }$$∘values. Validation of the shear modulus identification was also undertaken by comparing the results from the UD90$$^{\circ }$$∘and UD45$$^{\circ }$$∘specimens with a multi-directional (MD) configuration. Here, it was found that MD±45$$^{\circ }$$∘specimen shear modulus values where marginally lower than that from the UD specimens, in accordance with the lower fibre volume fraction of the MD laminate. Low strain rate sensitivities in the$$0.5-2\times$$0.5-2×10$$^{3}$$3 $$\hbox {s}^{-1}$$s-1regime evidenced in this work suggest previously published data (often from split-Hopkinson bar tests) may include both a material and systemi.e.testing apparatus response.
PKI is key to securing a post-Covid remote workforce
Authors: Trzupek Brian 
Published: October 2020

In just a few short months, the Covid-19 outbreak has dramatically changed the way that global employees work. In a recent IDC survey, respondents said they expect nearly 30% of their workforce will be working from home in 2021, compared to approximately 6% of their workforce prior to the pandemic. 1 With the Covid-19 outbreak, analysts estimate that we have witnessed two years of IT digital transformation in two months, and many of the changes are here to stay. Most organisations were forced to shift employees to remote work in just weeks or even days. The switchover has opened the door to a flood of new security threats. Multifactor authentication, such as PKI certificates and passwords, is the best approach to apply flexible, scalable security to protect networks and their users in today's world, explains Brian Trzupek of DigiCert.
Inpatient antibiotic utilization in the Veterans’ Health Administration during the coronavirus disease 2019 (COVID-19) pandemic
Authors: Dieringer Thomas D. , Furukawa Daisuke , Graber Christopher J. , Stevens Vanessa W. , Jones Makoto M. , Rubin Michael A. , Goetz Matthew Bidwell 
Published: October 2020

AbstractAntibiotic prescribing practices across the Veterans’ Health Administration (VA) experienced significant shifts during the coronavirus disease 2019 (COVID-19) pandemic. From 2015 to 2019, antibiotic use between January and May decreased from 638 to 602 days of therapy (DOT) per 1,000 days present (DP), while the corresponding months in 2020 saw antibiotic utilization rise to 628 DOT per 1,000 DP.
Effects of dietary curcumin on growth, antioxidant capacity, fatty acid composition and expression of lipid metabolism-related genes of large yellow croaker fed a high-fat diet
Authors: Ji Renlei , Xiang Xiaojun , Li Xueshan , Mai Kangsen , Ai Qinghui 
Published: October 2020

AbstractA 10-week feeding trial was conducted to investigate the effect of dietary curcumin (CC) on growth antioxidant responses, fatty acid composition, and expression of lipid metabolism-related genes of large yellow croaker fed a high-fat diet (HFD). Four diets (lipid level at 18 %) were formulated with different levels of curcumin (0, 0·02, 0·04 and 0·06 %). The best growth performance was found in the 0·04 % curcumin group, with the body and hepatic lipid levels lower than the control group (0 % CC). The content of TAG, total cholesterol and LDL-cholesterol was the least in the 0·06 % curcumin group. The lowest malondialdehyde and the highest superoxide dismutase, catalase and total antioxidant capacity were observed in the 0·04 % curcumin group. The 0·04 % curcumin group had higher expression of Δ6fad, elovl5 and elovl4 and showed higher hepatic n-6 and n-3 PUFA. Expression of ppara, cpt1, and aco was significantly increased, while expression of srebp1 and fas was dramatically decreased in curcumin groups compared with the control group. Overall, 0·04 % curcumin supplementation could mitigate the negative effects caused by HFD and promote growth via reducing hepatic lipid deposition, improving antioxidant activity and increasing PUFA of large yellow croaker. To conclude, abnormal hepatic lipid deposition was probably due to increased fatty acid oxidation and reduced de novo synthesis of fatty acids.
Quantitative author inputs to Earth science research publications: survey results, insights and potential applications
Authors: Ali Jason R. 
Published: October 2020

AbstractResults are reported of what is believed to be the first survey of the quantitative contributions Earth scientists make to their research publications. Based on a return of 26 (from 45; 254 total documents), two key patterns are observed. For most articles, there is a steady decrease in the roles of the first through fifth authors. The former fall from 65 ± 14% for two-author outputs, to 52 ± 9% for five, to 46 ± 10% for ten; fifth authors are perceived as having contributed 5–6%. The term ‘balanced’ is used to describe such contributor lists. The second pattern, which is labelled ‘imbalanced’, is recognized with teams of five or more and involves the first author shouldering a disproportionately large amount of the work; consequently, the inputs of the third and lesser authors range from small to negligible (5–1%). In some cases, it is observed in a few of a researcher’s publications (≤3); in others, it is more pervasive. There are two basic explanations: estimation problems and excessive numbers of authors, which can be split into two and three subcategories, respectively. The key features of the survey data are dwelt upon. The work concludes with an exploration of a proposed H-Index-type metric that is weighted by the contribution fractions a researcher makes to their publications. This, I contend, would be more reflective of their impact.
Multilevel influences of women’s empowerment and economic resources on risky sexual behaviour among young women in Zomba district, Malawi
Authors: Ward-Peterson Melissa , Fennie Kristopher , Baird Sarah , Coxe Stefany , Trepka Mary Jo , Madhivanan Purnima 
Published: October 2020

AbstractGender disparities are pronounced in Zomba district, Malawi. Among women aged 15–49 years, HIV prevalence is 16.8%, compared with 9.3% among men of the same age. Complex structural factors are associated with risky sexual behaviour leading to HIV infection. This study’s objective was to explore associations between multilevel measures of economic resources and women’s empowerment with risky sexual behaviour among young women in Zomba. Four measures of risky sexual behaviour were examined: ever had sex, condom use and two indices measuring age during sexual activity and partner history. Multilevel regression models and regression models with cluster-robust standard errors were used to estimate associations, stratified by school enrolment status. Among the schoolgirl stratum, the percentage of girls enrolled in school at the community level had protective associations with ever having sex (OR = 0.76; 95% CI: 0.60, 0.96) and condom use (OR = 1.06; 95% CI: 1.01, 1.11). Belief in the right to refuse sex was protective against ever having sex (OR = 0.76; 95% CI: 0.60, 0.96). Participants from households with no secondary school education had higher odds of ever having sex (OR = 1.59; 95% CI: 1.14, 2.22). Among the dropout stratum, participants who had not achieved a secondary school level of education had riskier Age Factor and Partner History Factor scores (β = 0.51; 95% CI: 0.23, 0.79, and β = 0.24; 95% CI: 0.07, 0.41, respectively). Participants from households without a secondary school level of education had riskier Age Factor scores (β = 0.26; 95% CI: 0.03, 0.48). Across strata, the most consistent variables associated with risky sexual behaviour were those related to education, including girl’s level of education, highest level of education of her household of origin and the community percentage of girls enrolled in school. These results suggest that programmes seeking to reduce risky sexual behaviour among young women in Malawi should consider the role of improving access to education at multiple levels.
Parent perspectives on preschoolers’ movement and dietary behaviours: a qualitative study in Soweto, South Africa
Authors: Klingberg Sonja , van Sluijs Esther MF , Draper Catherine E 
Published: October 2020

AbstractObjective:Childhood obesity is of increasing concern in South Africa, and interventions to promote healthy behaviours related to obesity in children are needed. Young children in urban low-income settings are particularly at risk of excess adiposity. The current study aimed to describe how parents of preschool children in an urban South African township view children’s movement and dietary behaviours, and associated barriers and facilitators.Design:A contextualist qualitative design was utilised with in-depth interviews conducted in the home setting and analysed using reflexive thematic analysis. Field notes were used to contextualise findings.Setting:Four neighbourhoods in a predominantly low-income urban township.Participants:Sixteen parents (fourteen mothers, two fathers) of preschool-age children were recruited via preschools.Results:Four themes were developed: children’s autonomy and the limits of parental control; balancing trust and fears; the appeal of screens; and aspirations and pressures of parenthood. Barriers to healthy behaviours included children’s food preferences, aspirations and pressures to consume unhealthy foods, other adults giving children snacks, lack of safe places to play, unhealthy food environments and underlying structural factors. Facilitators included set routines, the preschool environment, safe places to play and availability of healthy foods.Conclusions:Low-income families in Soweto face many structural challenges that cannot easily be addressed through public health interventions, but there may be opportunities for behavioural interventions targeting interpersonal and organisational aspects, such as bedtime routines and preschool snacks, to achieve positive changes. More research on preschoolers’ movement and dietary behaviours, and related interventions, is needed in South Africa.
Justifying supranational responses to the anti-constitutionalist challenge: Applying liberal multiculturalism as a background theory
Authors: KÖRTVÉLYESI ZSOLT , MAJTÉNYI BALÁZS 
Published: October 2020

AbstractThe European Union is bound to respect the national identities of member states. States might, on occasion, define their national identities in ways that breach inclusive constitutional values (e.g. equality) protected under TEU Article 2. The assumption behind the recognition of diverse constitutional identities is the peaceful coexistence of both, which is challenged by illiberal national developments. We see the relationship between the constitutional recognition of exclusive values (e.g. dominant ethnicity or religion) and inclusive constitutional values as a zero-sum game; every gain by the proponents of emergent authoritarianism translates to a loss for constitutional democracy. While exclusive norms appear in virtually every constitutional system, a critical mass of exclusive values can lead to the hollowing out of a democratic order, both at the national and supranational levels. To try to identify the line where this shift happens, we rely on the limits of toleration and recognition of exclusive norms and identity elements of minority communities in liberal theories of multiculturalism (e.g. Raz, Taylor, Kymlicka). We think that the case of illiberal minorities raises structurally similar theoretical questions, insights and experiences as the dilemma defined above, namely the challenge of illiberal states undermining fundamental EU values.
African Humid Period Precipitation Sustained by Robust Vegetation, Soil, and Lake Feedbacks
Authors: Chandan Deepak , Peltier W. Richard 
Published: October 2020

AbstractThe African Humid Period (∼11,000–5,000 years before present) was the most recent of several precessionally paced wet intervals during which an increase in the Northern Hemisphere summer incoming solar radiation intensifies the West African Monsoon leading to dramatic changes over northern Africa. However, insolation anomaly alone is not sufficient and feedbacks are essential for further amplification of the monsoon. The most significant feedbacks derive from the land surface, arising from changes to vegetation, soil properties, and distribution of surface water. We show that in contrast to previous studies that have explored the individual impacts of these feedbacks, a modern climate model yields a much greater increase in precipitation in response to their collective effect. Agreement with proxies is improved while the desert‐steppe transition is pushed further northward than in any previous study. In the West African Sahel, intensities of summer daily mean and extreme precipitation increase by 150% and 90%, respectively.
Ice Water Content as a Precursor to Tropical Cyclone Rapid Intensification
Authors: Wu S.‐N. , Soden B. J. , Alaka G. J. 
Published: October 2020

AbstractThis study examines how the structure and amount of cloud ice water content are related to rates of tropical cyclone (TC) intensification using CloudSat profiling radar measurements and simulations from the Hurricane Weather Research and Forecasting (HWRF) model. Observational studies have demonstrated the signal of TC intensification in the passive satellite measurements of frozen water concentration. However, the vertical and horizontal resolution of passive satellite observations are limited. CloudSat measurements and HWRF simulations provide high‐resolution data sets of ice water content to better understand its relationship with the rate of TC intensification. It is found that rapidly intensifying TCs have larger ice water content compared to TCs with slower intensification rates. Similar results are obtained even after accounting for the effect of initial TC intensity. Such precursors of rapidly intensifying TCs may be used to better understand and improve the prediction of TC intensification.
Measuring Global Mean Sea Level Changes With Surface Drifting Buoys
Authors: Elipot Shane 
Published: October 2020

AbstractCombining ocean model data and in situ Lagrangian data, I show that an array of surface drifting buoys tracked by a Global Navigation Satellite System (GNSS), such as the Global Drifter Program, could provide estimates of global mean sea level (GMSL) and its changes, including linear decadal trends. For a sustained array of 1,250 globally distributed buoys with a standardized design, I demonstrate that GMSL decadal linear trend estimates with an uncertainty less than 0.3 mm yr−1 could be achieved with GNSS daily random error of 1.6 m or less in the vertical direction. This demonstration assumes that controlled vertical position measurements could be acquired from drifting buoys, which is yet to be demonstrated. Development and implementation of such measurements could ultimately provide an independent and resilient observational system to infer natural and anthropogenic sea level changes, augmenting the ongoing tide gauge and satellites records.