bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of Glypican family genes in early-stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy and possible mechanisms
Authors: Liu Jun-qi , Liao Xi-wen , Wang Xiang-kun , Yang Cheng-kun , Zhou Xin , Liu Zheng-qian , Han Quan-fa , Fu Tian-hao , Zhu Guang-zhi , Han Chuang-ye , Su Hao , Huang Jian-lu , Ruan Guo-tian , Yan Ling , Ye Xin-ping , Peng Tao 
Published: December 2020

Abstract
Background: This study explored the prognostic significance of Glypican (GPC) family genes in patients with pancreatic ductal adenocarcinoma (PDAC) after pancreaticoduodenectomy using data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). Methods: A total of 112 PDAC patients from TCGA and 48 patients from GEO were included in the analysis. The relationship between overall survival and the expression of GPC family genes as well as basic clinical characteristics was analyzed using the Kaplan-Meier method with the log-rank test. Joint effects survival analysis was performed to further examine the relationship between GPC genes and prognosis. A prognosis nomogram was established based on clinical characteristics and prognosis-related genes. Prognosis-related genes were investigated by genome-wide co-expression analysis and gene set enrichment analysis (GSEA) was carried out to identify potential mechanisms of these genes affecting prognosis. Results: In TCGA database, high expression of GPC2 , GPC3 , and GPC5 was significantly associated with favorable survival (log-rank P = 0.031, 0.021, and 0.028, respectively; adjusted P value = 0.005, 0.022, and 0.020, respectively), and joint effects analysis of these genes was effective for prognosis prediction. The prognosis nomogram was applied to predict the survival probability using the total scores calculated. Genome-wide co-expression and GSEA analysis suggested that the GPC2 may affect prognosis through sequence-specific DNA binding, protein transport, cell differentiation and oncogenic signatures (KRAS, RAF, STK33, and VEGFA). GPC3 may be related to cell adhesion, angiogenesis, inflammatory response, signaling pathways like Ras, Rap1, PI3K-Akt, chemokine, GPCR, and signatures like cyclin D1, p53, PTEN. GPC5 may be involved in transcription factor complex, TFRC1, oncogenic signatures (HOXA9 and BMI1), gene methylation, phospholipid metabolic process, glycerophospholipid metabolism, cell cycle, and EGFR pathway. Conclusion: GPC2 , GPC3 , and GPC5 expression may serve as prognostic indicators in PDAC, and combination of these genes showed a higher efficiency for prognosis prediction.
Genome-wide association analysis reveals genetic variations and candidate genes associated with salt tolerance related traits in Gossypium hirsutum
Authors: Xu Peng , Guo Qi , Meng Shan , Zhang Xianggui , Xu Zhenzhen , Guo Wangzhen , Shen Xinlian 
Published: December 2020

Abstract
Background: Cotton is more resistant to salt and drought stresses as compared to other field crops, which makes itself as a pioneer industrial crop in saline-alkali lands. However, abiotic stresses still negatively affect its growth and development significantly. It is therefore important to breed salt tolerance varieties which can help accelerate the improvement of cotton production. The development of molecular markers linked to causal genes has provided an effective and efficient approach for improving salt tolerance.Results: In this study, a genome-wide association study (GWAS) of salt tolerance related traits at seedling stage was performed based on two years of phenotype identification for 217 representative upland cotton cultivars by genotyping-by-sequencing (GBS) platform. A total of 51,060 single nucleotide polymorphisms (SNPs) unevenly distributed among 26 chromosomes were screened across the cotton cultivars, and 25 associations with 27 SNPs scattered over 12 chromosomes were detected significantly (-log10p>4) associated with three salt tolerance related traits in 2016 and 2017. Among these, the associations on chromosome A13 and D08 for relative plant height (RPH), A07 for relative shoot fresh matter weight (RSFW), A08 and A13 for relative shoot dry matter weight (RSDW) were expressed in both environments, indicating that they were likely to be stable quantitative trait loci (QTLs). A total of 12 salt-induced candidate genes were identified differentially expressed by the combination of GWAS and transcriptome analysis. Three promising genes were selected for preliminary function verification of salt tolerance. The increase of GH_A13G0171-silenced plants in salt related traits under salt stress indicated its negative function in regulating the salt stress response.Conclusions: These results provided important genetic variations and candidate genes for accelerating the improvement of salt tolerance in cotton.
Spatio-temporal variations in terrestrial water storage and its controlling factors in the Eastern Qinghai-Tibet Plateau
Authors: Zhu Yu , Liu Shiyin , Yi Ying , Qi Miaomiao , Li Wanqiu , Saifullah Muhammad , Zhang Sidou , Wu Kunpeng 
Published: December 2020

AbstractThe nature of the heterogeneity of terrestrial water storage (TWS) in the Eastern Qinghai-Tibet Plateau (EQTP) is poorly understood because of the lack of validated datasets and the complex topographical conditions. In this study, monthly GRACE Level 2 Release 6 (RL06) products were employed to characterize TWS changes between April 2002 and August 2016 in the EQTP. Based on the observations and hydrological model output, the dominant factors contributing to the changes in TWS in sub-basins, and areas of TWS decrease and increase were analyzed systematically. We concluded that the TWS in the EQTP showed a slight decreasing trend from 2002 to 2016 with obvious spatial heterogeneity. The decrease in TWS may be attributed to the increase in evapotranspiration, which explains approximately 59% of the variations. In the region where a substantial decrease in TWS was observed, the trend primarily depended on evapotranspiration, and was certainly affected by glacial ablation. Moreover, the expansion of lakes supplemented by glaciers was the main cause of TWS change in the areas where TWS increased. A decrease in TWS mainly occurred in summer and was mainly due to the increase in evapotranspiration because of warming, an increase in wind speed, and a decrease in relative humidity.
Adaptation measures (AMs) and mitigation policies (MPs) to climate change and sustainable blue economy: a global perspective
Authors: Hossain Fahim 
Published: December 2020

AbstractErratic patterns in climate have been forcing people to develop new adaptation and mitigation tools. Although world leaders have agreed to control greenhouse gases' (GHGs) emission, the current rate of emission may not stop global climate change (GCC). Scientists have been working to scientifically explain the effects of GHG emission on GCC, however, all climate changing phenomena may not be fully understandable now and more research is necessary to comprehend those knowledge gaps. Climate change has been severely affecting the ecological and socio-economic development but these effects can be mitigated by supporting sustainable technological and economic development as AMs and MPs. MPs to climate change may trade off the negative impacts of GCC and exploring and employing lucrative opportunities in blue economy can help in developing those AMs and MPs. Moreover, it is not possible to rapidly divert all global manufacturing processes into benign technological and economic perfection. For this reason, Bangladesh and other coastal countries are very aware of the need to introduce cost-effective AMs and MPs and society and environment oriented blue economy. Some worthwhile adaptation and mitigation strategies are discussed to minimize the carbon footprint, as remedies to curtail GCC impacts. Scientific relations of GCC with GHG emission and opportunities of blue economy are also explored.
Waterminer – a regional spatio-temporal approach to water reuse management in mining areas in Vietnam
Authors: Greassidis S. , Trinh Quoc V. , Brömme K. , Stolpe H. 
Published: December 2020

Abstract
Mining is usually associated with draining of large quantities of water. On the other hand, mining operations themselves are water users for purposes like coal or ore washing, dust mitigation, recultivation, etc. The normally existing water surplus can be seen as a resource for public purposes instead of discharging the water to rivers and the sea. It is typical for the mining operation that these water amounts vary spatio-temporally according to the mining process. The R&D project WaterMiner investigates the example of the Hon Gai hard coal mining area in Ha Long, Vietnam, as to how and to what extent under the variable spatio-temporal conditions the mine water can cover the water demand in the mines themselves and contribute to the public water supply in the surrounding settlement area of Hon Gai. The spatio-temporal change of mine water drainage, mine water treatment and mine-internal water use and the potential mine-external water use volumes in the project region are investigated by a material flow model and visualized by Sankey diagrams, maps, and tables. Several options for delivery of mine water for mine-external water uses as a contribution to the public water supply are shown.
Monitoring of pollution factors of solidified body leachate in a drilling well site and its influence on the surface water environment
Authors: Liu Zhikun , Zhang Chaoqun , Li Qi 
Published: December 2020

Abstract
Aiming at the pollution of the leaching solution of the solidified body in the wellbore, a water eutrophication level evaluation algorithm based on the optimized analytic hierarchy process is proposed from the current situation of many factors affecting the eutrophication of the water body and the difficulty of evaluation. Based on this, the user-oriented PC software monitoring system was developed, which mainly includes three major modules: surface water environment monitoring, water eutrophication evaluation, water bloom prediction and warning, and system assistance. The surface water environment monitoring module can receive and display the surface water environment parameter information in real time, and has the functions of data comparison analysis and historical data search, and the eutrophication assessment and water bloom prediction and warning module can analyze the eutrophication status of water bodies in real time and provide short-term and medium-term warnings for water blooms. This research can promote the control of the leachate pollution of the wellbore in the wellbore and the optimization of the surface water environment.
Evaluation of modified permeable pavement systems with coal gangue to remove typical runoff pollutants under simulated rainfall
Authors: Zhang Xiaoran , Tian Yiran , Liu Junfeng , Wang Yinrui , Zhang Ziyang , Li Haiyan 
Published: December 2020

Abstract
Coal gangue (CG) as mineral waste was properly treated and applied as the filter media in permeable pavement systems due to its good sorption ability and mechanical strength. Batch experiments show the maximum adsorption capacity of calcined CG to phosphorus could reach 2.63 mg/g. To evaluate the removal effect of typical runoff pollutants including chemical oxygen demand (COD), total nitrogen (TN), total phosphorus (TP) and ammonia (NH4+-N), the gravel and sand in a traditional pavement system were replaced by CG respectively. The leaching behavior of the four pollutants in CG modified systems is limited and comparable with traditional system, indicating pretreated CG as filler would not cause environmental risk. CG-based pavement systems improved the removal efficiency of the four pollutants especially for TP. The removal mechanisms including interception, adsorption and microorganism degradation. The removal rates of COD, NH4+-N and TN by CG modified and traditional systems decreased with rainfall duration, while it is not obviously changed with rainfall recurrence period and drying period. Overall, the permeable pavement with CG layers that replaced both sand and gravel layers show best removal efficiency of all pollutants investigated especially for TP (&gt;95%). This study provides a new way for CG utilization and gives the reference for the process design of permeable pavement.
Commissioning of the new water line of the Central wastewater treatment plant in Prague and its impact on the operation of the existing water line
Authors: Wanner J. , Rosický J. , Kovařík J. , Srb M. , Lánský M. , Sýkora P. 
Published: December 2020

Abstract
This paper describes the commissioning of the new water line (NWL) of the Central wastewater treatment plant in Prague and also the gradual reduction of the existing water line (EWL) loading. Concerning the NWL, the gradual start-up of the process without inoculation will be described. As to the EWL, the presentation describes the adaptation of the EWL operation to the relatively quick reduction of loading to approximately 35%.
Pilot-scale phycoremediation using Muriellopsis sp. for wastewater reclamation in the Atacama Desert: microalgae biomass production and pigment recovery
Authors: Cavieres L. , Bazaes J. , Marticorena P. , Riveros K. , Medina P. , Sepúlveda C. , Riquelme C. 
Published: December 2020

Abstract
Municipal wastewater phycoremediation represents a promising circular economy-based process for wastewater reclamation used to recover water and produce biomass. This study aimed to evaluate a pilot-scale phycoremediation system, using the most efficient strain of microalgae for wastewater reclamation in the Atacama Desert. Nitrogen and phosphorus removal, as well as biomass growth, were compared in different microalgae treatments, namely Muriellopsis sp., Scenedesmus almeriensis, Chlamydomonas segnis, Chlorella pyrenoidosa and Chlorella vulgaris. The most efficient treatments, Muriellopsis sp. and S. almeriensis, were scaled up to 20-L bubble column reactors to evaluate nutrient removal and biomass biochemical profile for potential biotechnological application. Finally, Muriellopsis sp. was selected for a pilot-scale phycoremediation experiment (800-L raceway), which removed 84% of nitrogen, 93% of phosphorus and other chemical compounds after 4 days of treatment to meet most of the Chilean standards for irrigation water (NCh. 1333. DS. MOP No. 867/78). Faecal coliforms count was reduced by 99.9%. Furthermore, biomass productivity reached 104.25 mg·L–1·day–1 value with 51% protein, and pigment content of 0.6% carotenoid, with 0.3% lutein. These results indicate the potential of wastewater phycoremediation at an industrial scale for the production of irrigation water and carotenoid using Muriellopsis sp.
Investigation on the adsorption of antibiotics from water by metal loaded sewage sludge biochar
Authors: Fan Xiulei , Qian Zheng , Liu Jiaqiang , Geng Nan , Hou Jun , Li Dandan 
Published: December 2020

Abstract
Application of sewage sludge biochar as an adsorbent for antibiotics treatment has obtained special attention owning to its low cost and surface functionality. Three metal ions were selected to modify sewage sludge biochar through the pyrolysis with the metal loaded method. Fe loaded sewage sludge biochar (BC-Fe), Al loaded sewage sludge biochar (BC-Al) and Mn loaded sewage sludge biochar (BC-Mn) were characterized and used to explore the performance of adsorbing tetracycline (TC), sulfamethoxazole (SMZ) and amoxicillin (AMC). BC-Fe, BC-Al and BC-Mn possessed rougher surfaces, larger specific surface area and better pore structure. Intra-particle diffusion and Langmuir models were more suitable to describe the adsorption process. The maximum adsorption amount of TC, SMZ and AMC could reach 123.35, 99.01 and 109.89 mg/g by BC-Fe. Furthermore, the main mechanism of antibiotics adsorption by metal loaded sewage sludge biochars might be pores filling, Van der Waals forces and H-bonding. The study can not only solve the problems associated with the pollution of antibiotics from wastewater, but also reduced the treatment pressure of sewage sludge effectively.
Nanostructured faujasite zeolite as metal ion adsorbent: kinetics, equilibrium adsorption and metal recovery studies
Authors: Goncalves Mariana B. , Schmidt Djanyna V. C. , dos Santos Fabiana S. , Cipriano Daniel F. , Gonçalves Gustavo R. , Freitas Jair C. C. , de Pietre Mendelssolm K. 
Published: December 2020

Abstract
The hydrothermal synthesis of nano-faujasite has been successfully performed and the effects of some crystallization parameters were investigated, along with the use of this material as a heavy-metal ion adsorbent. X-ray diffraction patterns have shown that the structure of the nano-faujasite is strongly dependent on both the crystallization time and the alkalinity of the synthesis medium. According to N2 physisorption, X-ray fluorescence, SEM/EDS, and solid state 29Si and 27Al NMR data, the produced nano-faujasite consists of a solid with low molar Si/Al ratio (1.7), with high availability of ion exchange sites and high surface area/small particle size, allowing easy diffusion of metal ions to adsorbent active sites. As a consequence, an excellent performance on removal of Cd2+, Zn2+ and Cu2+ ions was found for this solid. The adsorption capacity followed the order Cd2+ (133 mg·g−1) &gt; Zn2+ (115 mg·g−1) &gt; Cu2+ (99 mg·g−1), which agrees with the order of increasing absolute values of the hydration energy of the metal ions. Kinetic studies and adsorption isotherms showed that the metal ion removal takes place by ion exchange on the monolayer surface of the nano-faujasite. The electrochemical recovery of copper in metallic form exhibited an efficiency of 80.2% after 120 min, which suggests that this process can be adequately implemented for full-scale metal removal.
Gifted child in kindergarten – assessment pitfalls
Authors: Kwiatkowska Elżbieta 
Published: December 2020

Issues and considerations raised in the article are related to the identification (assessment) of gifted children, often described in literature, in relation to selected theories of ability. It is very likely that a gifted child characterized by the specificity of early childhood, commonly defined as intelligent, with high cognitive abilities, will abandonits innate, unique potential, entangling in various types of “problems”, taking on the features of the syndrome of inadequate school achievements, etc. in the future, as a result of adverse environmental impacts, the coincidence of events. The individual case studies presented in the article are intended to illustrate the significance of individual impacts on a gifted child of preschool age, due to the specific developmental peculiarities of this period.
Metabolism and Interactions of Chloroquine and Hydroxychloroquine with Human Cytochrome P450 Enzymes and Drug Transporters
Authors: Rendic Slobodan , Guengerich Frederick Peter 
Published: December 2020

Background::
In clinical practice, chloroquine and hydroxychloroquine are often co-administered
with other drugs in the treatment of malaria, chronic inflammatory diseases, and COVID-19. Therefore, their
metabolic properties and the effects on the activity of cytochrome P450 (P450, CYP) enzymes and drug transporters
should be considered when developing the most efficient treatments for patients.

Methods::
Scientific literature on the interactions of chloroquine and hydroxychloroquine with human P450 enzymes
and drug transporters, was searched using PUBMED.Gov (https://pubmed.ncbi.nlm.nih.gov/) and the
ADME database (https://life-science.kyushu.fujitsu.com/admedb/).

Results::
Chloroquine and hydroxychloroquine are metabolized by P450 1A2, 2C8, 2C19, 2D6, and 3A4/5 in
vitro and by P450s 2C8 and 3A4/5 in vivo by N-deethylation. Chloroquine effectively inhibited P450 2D6 in
vitro; however, in vivo inhibition was not apparent except in individuals with limited P450 2D6 activity. Chloroquine
is both an inhibitor and inducer of the transporter MRP1 and is also a substrate of the Mate and MRP1
transport systems. Hydroxychloroquine also inhibited P450 2D6 and the transporter OATP1A2.

Conclusions::
Chloroquine caused a statistically significant decrease in P450 2D6 activity in vitro and in vivo,
also inhibiting its own metabolism by the enzyme. The inhibition indicates a potential for clinical drug-drug interactions
when taken with other drugs that are predominant substrates of the P450 2D6. When chloroquine and
hydroxychloroquine are used clinically with other drugs, substrates of P450 2D6 enzyme, attention should be
given to substrate-specific metabolism by P450 2D6 alleles present in individuals taking the drugs.
Withdrawal Notice: Elucidating the Disparate Inhibitory Mechanisms of
Novel 1-Heteroaryl-1,3-Propanediamine Derivatives and Maraviroc towards
C-C Chemokine Receptor 5: Insights for Structural Modifications in HIV-1
Drug Discovery
Authors: Appiah-Kubi Patrick , Olotu Fisayo Andrew , Soliman Mahmoud E. S. 
Published: December 2020

Since the authors are not responding to the editor's requests to fulfill the editorial requirement, therefore, the article has been
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Characterization and Antibacterial Properties of Eriobotrya Japonica Extract Loaded Silver-Nanoparticles
Authors: Sajid Arfaa , Manzoor Qaisar , Sajid Anam , Imran Muhammad , Khalid Shanza , Arshad Zobia , Saleem Aimon , Iahtisham-Ul-Haq  , Aslam Farhan 
Published: December 2020

Background:
Currently, developing methods for the formation of nanoparticles with antimicrobial
properties based on green chemistry are the research hotspots. In this research, green
biosynthesis of Eriobotrya japonica extract loaded silver nanoparticles and their characterization
were the main objectives to achieve.

Methods:
Green synthesis of E. japonica leaves extract-loaded silver nanoparticles (AgNPs) was
carried out and its effect on bacterial growth was examined. The reduction of silver ions in the solution
was observed using a UV-Vis spectrophotometer. The properties of AgNPs were assessed using
Scanning Electron Microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and Xray
Diffraction (XRD). Also, their antibacterial effects were checked against Staphylococcus aureus
and Escherichia coli.

Results:
It was revealed that 5-50 nm sized spherical to elongated nanoparticles were synthesized
that possessed comparatively better antibacterial potential against E. coli and S. aureus than the
conventional extract of the E. japonica leaves.

Conclusions:
Green synthesis and effective utilization of Eriobotrya japonica extract loaded silver
nanoparticles are a promising approach for nanoparticle production avoiding negative environmental
impacts.