bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Physical Therapy– and Occupational Therapy–Based Rehabilitation in People Who Have Glioma and Are Undergoing Active Anticancer Treatment: Single-Blind, Randomized Controlled Trial
Authors: Hansen Anders , Pedersen Christian Bonde , Jarden Jens Ole , Beier Dagmar , Minet Lisbeth Rosenbek , Søgaard Karen 
Published: December 2019

Abstract

Background
It is recommended that people with gliomas engage in rehabilitation, but high-quality evidence to support this recommendation is lacking.

Objective
This study assesses the effectiveness of a physical therapy– and occupational therapy–based rehabilitation intervention compared with usual rehabilitation care for quality of life (QoL) during active anticancer treatment.

Design
This study was a randomized controlled trial.

Setting
The study took place in Odense University Hospital, Denmark.

Participants
The trial included people with gliomas who were functionally independent.

Intervention
The participants were randomly assigned to a supervised rehabilitation intervention or usual rehabilitation care during the active anticancer period. The supervised rehabilitation included physical therapy and occupational therapy-based interventions.

Measurements
The primary outcome was the between-group difference in the overall QoL from baseline to the 6-week follow-up. It was self-rated with the global health status (GHS)/QoL domains from the European Organization for Research and Treatment of Cancer Questionnaire. Eighty-eight participants per group were required to find a 10% between-group difference from baseline to the 6-week follow-up. Secondary outcomes were the health-related QoL domains, symptomatology, and functional performance.

Results
A total of 64 participants were included (32 in the intervention group and 32 in the control group). At follow-up, the intervention group self-rated a nonsignificantly better score for GHS/QoL than the control group (adjusted mean difference = 8.7% [95% confidence interval = −4.36 to 21.79]). Compared with the control group, the intervention group had consistently better results on self-rated secondary outcomes, including cognitive functioning (β = 16.2) and fatigue (β = −13.4), and objectively measured aerobic power (β = 2.6).

Limitations
The number of participants and duration of follow-up were inadequate to determine if the intervention was superior to the current usual rehabilitation care.

Conclusions
The physical therapy– and occupational therapy–based rehabilitation intervention did not affect GHS/QoL. However, the trial found promising significant effects on both objective and self-reported secondary outcomes, making rehabilitation efforts during active anticancer treatment promising.
How Do Laws and Institutions Affect Recovery Rates for Collateral?
Authors: Degryse Hans , Ioannidou Vasso , Liberti José María , Sturgess Jason 
Published: December 2019

Abstract
Using unique internal bank data on ex ante appraised liquidation and market values of assets pledged as collateral in sixteen countries, we show that laws and institutions that strengthen creditor protection increase expected recovery rates for collateral. Stronger creditor protection increases expected recovery rates for movable collateral relative to immovable collateral and shifts the composition of collateral toward movable assets, thereby increasing debt capacity through both higher loan-to-values and attenuating the creditor’s liquidation bias. Our results suggest that the recovery rate for collateral is an important first-stage mechanism through which creditor protection can improve contracting efficiency and enhance access to credit.
Received September 17, 2018; editorial decision July 9, 2019 by Editor Andrew Ellul.
Disease activity measures at baseline predict structural damage progression: data from the randomized, controlled AMPLE and AVERT trials
Authors: Keystone Edward C , Ahmad Harris A , Yazici Yusuf , Bergman Martin J 
Published: December 2019

Abstract

Objective
Data from two double-blind, randomized, Phase III studies were analysed to investigate the ability of Routine Assessment of Patient Index Data 3, DAS28 (CRP), modified (M)-DAS28 (CRP) and Simplified or Clinical Disease Activity Indices to predict structural damage progression in RA.

Methods
This post hoc analysis included data from the 2-year Abatacept vs adaliMumab comParison in bioLogic-naïvE RA subjects with background MTX (AMPLE) trial in biologic-naïve patients with active RA (&lt;5 years) and an inadequate response to MTX, and the 12-month treatment period of the Assessing Very Early Rheumatoid arthritis Treatment (AVERT) trial in MTX-naïve patients with early RA (⩽2 years) and poor prognostic indicators. Adjusted logistic regression analysis assessed the relationship between baseline disease activity and structural damage progression (defined as change from baseline greater than the smallest detectable change) at 12 and 24 months in AMPLE and 6 and 12 months in AVERT. Areas under the receiver operating characteristic curves for the impact of baseline disease activity on structural damage progression were calculated.

Results
Adjusted logistic regression analyses included all randomized and treated patients in AMPLE (N = 646) and those who received abatacept plus MTX or MTX monotherapy in AVERT (N = 235). Baseline Routine Assessment of Patient Index Data 3, DAS28 (CRP) and M-DAS28 (CRP) scores significantly predicted structural progression at months 12 and 24 in AMPLE (P &lt; 0.05) and months 6 and 12 in AVERT (P &lt; 0.01), and were stronger predictors than Simplified or Clinical Disease Activity Indices.

Conclusion
In this post hoc analysis of two patient populations with RA, Routine Assessment of Patient Index Data 3, DAS28 (CRP) and M-DAS28 (CRP) were good at predicting structural damage.

Trial registration
ClinicalTrials.gov, http://clinicaltrials.gov: NCT00929864 (AMPLE); NCT01142726 (AVERT).
Epidemiological profile and north–south gradient driving baseline systemic involvement of primary Sjögren’s syndrome
Authors: Brito-Zerón Pilar , Acar-Denizli Nihan , Ng Wan-Fai , Horváth Ildiko Fanny , Rasmussen Astrid , Seror Raphaele , Li Xiaomei , Baldini Chiara , Gottenberg Jacques-Eric , Danda Debashish , Quartuccio Luca , Priori Roberta , Hernandez-Molina Gabriela , Armagan Berkan , Kruize Aike A , Kwok Seung-Ki , Kvarnstrom Marika , Praprotnik Sonja , Sene Damien , Gerli Roberto , Solans Roser , Rischmueller Maureen , Mandl Thomas , Suzuki Yasunori , Isenberg David , Valim Valeria , Wiland Piotr , Nordmark Gunnel , Fraile Guadalupe , Bootsma Hendrika , Nakamura Hideki , Giacomelli Roberto , Devauchelle-Pensec Valerie , Hofauer Benedikt , Bombardieri Michele , Trevisani Virginia Fernandes Moça , Hammenfors Daniel , Pasoto Sandra G , Retamozo Soledad , Gheita Tamer A , Atzeni Fabiola , Morel Jacques , Vollenweider Cristina , Zeher Margit , Sivils Kathy , Xu Bei , Bombardieri Stefano , Sandhya Pulukool , De Vita Salvatore , Minniti Antonina , Sánchez-Guerrero Jorge , Kilic Levent , van der Heijden Eefje , Park Sung-Hwan , Wahren-Herlenius Marie , Mariette Xavier , Ramos-Casals Manuel ,   for the Sjögren Big Data Consortium
Published: December 2019

Abstract

Objective
To characterize the systemic phenotype of primary Sjögren’s syndrome at diagnosis by analysing the EULAR-SS disease activity index (ESSDAI) scores.

Methods
The Sjögren Big Data Consortium is an international, multicentre registry based on worldwide data-sharing cooperative merging of pre-existing databases from leading centres in clinical research in Sjögren’s syndrome from the five continents.

Results
The cohort included 10 007 patients (9352 female, mean 53 years) with recorded ESSDAI scores available. At diagnosis, the mean total ESSDAI score was 6.1; 81.8% of patients had systemic activity (ESSDAI score ≥1). Males had a higher mean ESSDAI (8.1 vs 6.0, P &lt; 0.001) compared with females, as did patients diagnosed at &lt;35 years (6.7 vs 5.6 in patients diagnosed at &gt;65 years, P &lt; 0.001). The highest global ESSDAI score was reported in Black/African Americans, followed by White, Asian and Hispanic patients (6.7, 6.5, 5.4 and 4.8, respectively; P &lt; 0.001). The frequency of involvement of each systemic organ also differed between ethnic groups, with Black/African American patients showing the highest frequencies in the lymphadenopathy, articular, peripheral nervous system, CNS and biological domains, White patients in the glandular, cutaneous and muscular domains, Asian patients in the pulmonary, renal and haematological domains and Hispanic patients in the constitutional domain. Systemic activity measured by the ESSDAI, clinical ESSDAI (clinESSDAI) and disease activity states was higher in patients from southern countries (P &lt; 0.001).

Conclusion
The systemic phenotype of primary Sjögren’s syndrome is strongly influenced by personal determinants such as age, gender, ethnicity and place of residence, which are key geoepidemiological players in driving the expression of systemic disease at diagnosis.
Neurobiological changes during the peripartum period: implications for health and behavior
Authors: Cárdenas Emilia F , Kujawa Autumn , Humphreys Kathryn L 
Published: December 2019

AbstractPregnancy and the transition to parenthood is an important period marked by dramatic neurobiological and psychosocial changes that may have implications for the health of women and offspring. Although human and non-human animal research suggests that the brain undergoes alterations during the peripartum period, these changes are poorly understood. Here, we review existing research, particularly human neuroimaging and psychophysiological research, to examine changes in brain structure and function during the peripartum period and discuss potential implications for the health of women and offspring. First, we discuss the potential causes of these changes across pregnancy, including physiological and psychosocial factors. Next, we discuss the evidence for structural and functional changes in the brain during pregnancy and into the postpartum period, noting the need for research conducted prospectively across human pregnancy. Finally, we propose potential models of individual differences in peripartum neurobiological changes (i.e. hypo-response, typical response, hyper-response) and emphasize the need to consider trajectories of change in addition to pre-existing factors that may predict maternal adjustment to parenthood. We suggest that the consideration of individual differences in neurobiological trajectories across pregnancy may contribute to a better understanding of risk for negative health and behavior outcomes for women and offspring.
Robust stability of trait-like vulnerability or resilience to common types of sleep deprivation in a large sample of adults
Authors: Yamazaki Erika M , Goel Namni 
Published: December 2019

Abstract

Study Objectives
Sleep loss produces large individual differences in neurobehavioral responses, with marked vulnerability or resilience among individuals. Such differences are stable with repeated exposures to acute total sleep deprivation (TSD) or chronic sleep restriction (SR) within short (weeks) and long (years) intervals. Whether trait-like responses are observed to commonly experienced types of sleep loss and across various demographically defined groups remains unknown.

Methods
Eighty-three adults completed two baseline nights (10 h–12 h time-in-bed, TIB) followed by five 4 h TIB SR nights or 36 h TSD. Participants then received four 12-h TIB recovery nights followed by five SR nights or 36 h TSD, in counterbalanced order to the first sleep loss sequence. Neurobehavioral tests were completed every 2 h during wakefulness.

Results
Participants who displayed neurobehavioral vulnerability to TSD displayed vulnerability to SR, evidenced by substantial to near perfect intraclass correlation coefficients (ICCs; 78%–91% across measures). Sex, race, age, body mass index (BMI), season, and sleep loss order did not impact ICCs significantly. Individuals exhibited significant consistency of responses within, but not between, performance and self-reported domains.

Conclusions
Using the largest, most diverse sample to date, we demonstrate for the first time the remarkable stability of phenotypic neurobehavioral responses to commonly experienced sleep loss types, across demographic variables and different performance and self-reported measures. Since sex, race, age, BMI, and season did not affect ICCs, these variables are not useful for determining stability of responses to sleep loss, underscoring the criticality of biological predictors. Our findings inform mathematical models and are relevant for the general population and military and health professions.
Associations between sleep problems and ADHD symptoms among adolescents: findings from the Shandong Adolescent Behavior and Health Cohort (SABHC)
Authors: Liu Xianchen , Liu Zhen-Zhen , Liu Bao-Peng , Sun Shi-Hua , Jia Cun-Xian 
Published: December 2019

Abstract

Study Objectives
Sleep problems and symptoms of attention-deficit hyperactivity disorder (ADHD) in adolescence are common. Little is known about the prospective the prospective associations between sleep and subsequent ADHD symptoms in adolescents. This study examined the prospective associations between sleep problems and subsequent ADHD symptoms in a large sample of adolescents.

Methods
Participants included 7072 adolescents from the Shandong Adolescent Behavior and Health Cohort (SABHC) study in Shandong, China. Participants were initially assessed in November–December of 2015 and were reassessed 1-year later in 2016. Sleep duration, sleep problems, and psychosocial information were collected using a structured questionnaire. ADHD symptoms were measured by the Achenbach Child Behavior Checklist-Youth Self-Report.

Results
At baseline, 7.6% participants had clinically relevant ADHD symptoms, which were highly comorbid with sleep problems including insomnia symptoms, poor sleep quality, symptoms of restless legs syndrome (RLS), frequent snoring, and short sleep duration. Of the 6531 participants without clinically relevant ADHD symptoms at baseline, 4.5% reported clinically relevant ADHD symptoms at 1-year follow-up. After adolescent and family covariates were adjusted for, insomnia (OR = 2.09, 95% CI = 1.45–3.02), RLS (OR = 1.47, 95% CI = 1.02–2.11), and frequent snoring (OR = 2.30, 95% CI = 1.36–3.90) were all significantly associated with subsequent ADHD symptoms.

Conclusion
ADHD symptoms and sleep problems are highly comorbid. Insomnia, RLS and frequent snoring appear to be significant predictors of subsequent ADHD symptoms. Our study highlights the importance of assessing and managing sleep problems for prevention and clinical treatment of ADHD symptoms in adolescence.
Measuring Regional Ethnolinguistic Diversity in Sub-Saharan Africa: Surveys vs. GIS
Authors: Gershman Boris , Rivera Diego 
Published: December 2019

Abstract
This paper compares two approaches to measuring subnational ethnolinguistic diversity in Sub-Saharan Africa, one based on censuses and large-scale population surveys and the other relying on the use of geographic information systems (GIS). The two approaches yield sets of regional fractionalization indices that show a moderately positive correlation, with a stronger association across rural areas. These differences matter for empirical analysis: in a common sample of regions, survey-based indices of deep-rooted diversity show a more strongly negative association with a range of development indicators relative to their highest-quality GIS-based counterparts.
Medium-Run Impacts of Management Training in Garment Clusters
Authors: Higuchi Yuki , Mhede Edwin Paul , Nam Vu Hoang , Sonobe Tetsushi 
Published: December 2019

Abstract
This paper investigates the impact of management training programs on garment clusters in Vietnam and Tanzania. The study found that in the medium run firms showed improvement once they had identified useful practices and adapted them to their operations. Although it takes a few years to experience a significant impact on incomes, management training can increase not just management scores but also incomes or value added.
The Management of Postsurgical Wound Complications with Plasma Rich in Growth Factors: A Preliminary Series
Authors: Anitua Eduardo , Pino Ander 
Published: December 2019

ABSTRACT

BACKGROUND
Postsurgical wound complications constitute a relevant public health issue because of their frequency. There is growing evidence regarding platelet-based autologous therapies that support their use in promoting cutaneous regeneration.

OBJECTIVE
To provide preliminary data regarding the potential benefit of plasma rich in growth factors (PRGF) in the management of postsurgical wound complications.

DESIGN
Three patients suffering from poorly healing severe full-thickness wounds were treated with either one or a combination of different formulations derived from their own blood: autologous clot, fibrin membrane, injectable plasma, or topical ointment. Different treatment protocols are described, and follow-up results are reported.

RESULTS
Within 4 to 12 months, the treated wounds healed completely with no signs of infection, tissue necrosis, or functional impairment. No adverse events were reported.

CONCLUSION
Additional clinical trials with long-term follow-up periods and larger patient populations are needed to establish the efficacy of PRGF technology. However, these preliminary findings suggest that PRGF merits further randomized controlled studies exploring its capacity to accelerate re-epithelialization and restore functional integrity to cutaneous ulcers resulting from surgical complications.
Making Decisions in the Era of the Clinical Decision Rule: How Emergency Physicians Use Clinical Decision Rules
Authors: Chan Teresa M. , Mercuri Mathew , Turcotte Michelle , Gardiner Emily , Sherbino Jonathan , de Wit Kerstin 
Published: December 2019

Purpose
Physicians are often asked to integrate clinical decision rules (CDRs) with their own cognitive processes to reach a diagnosis. Clinicians, researchers, and educators must understand these cognitive processes to evaluate and improve the diagnostic process. The authors sought to explore emergency physicians’ diagnostic processes and to examine how they integrated CDRs into their reasoning using simulated cases (with chest pain or leg pain).

Method
From August 2015 to July 2016, 16 practicing emergency physicians from 3 teaching hospitals associated with McMaster University, Ontario, Canada, were interviewed via a novel “teach aloud” protocol. Six videos of simulated patients with chest pain, breathlessness, or leg discomfort were used as prompts for the physicians to demonstrate their diagnostic thinking. Using a constructivist grounded theory analysis, 3 investigators independently reviewed the interview transcripts, meeting regularly to discuss identified themes and subthemes until sufficiency was reached.

Results
A model to describe how clinicians integrate their own decision making with CDRs was developed, showing that physicians engage in an iterative diagnostic process that repeatedly refines the differential diagnosis list. The steps in the diagnostic process were: refinement of the differential diagnosis, ordering a hierarchy of risk, the decision to test, choosing the tests, and interpreting test results. Physicians applied CDRs when they had already decided to test.

Conclusions
To date, CDRs assume a static, linear model of clinical decision making. Findings demonstrate that participants engaged in iterative and dynamic decision-making processes that changed throughout their patient encounter, contingent on multiple contextual features. Understanding these processes could inform future development of CDRs and educational strategies around these decision aids.
Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings
Authors: Yazer Mark H. , Spinella Philip C. , Doyle Leilani , Kaufman Richard M. , Dunn Robyn , Hess John R. , Filho Luiz Amorim , Fontaine Magali , Gathof Birgit , Jackson Bryon , Murphy Michael F. , Pasion Jeremiah , Raval Jay S. , Rosinski Kristin , Seheult Jansen , Shih Andrew W. , Sperry Jason , Staves Julie , Tuott Erin E. , Ziman Alyssa , Triulzi Darrell J. ,   on behalf of the Biomedical Excellence for Safer Transfusion Collaborative*
Published: December 2019

Abstract

Background
Group O erythrocytes and/or whole blood are used for urgent transfusions in patients of unknown blood type. This study investigated the impact of transfusing increasing numbers of uncrossmatched type O products on the recipient’s first in-hospital ABO type.

Methods
This was a retrospective cohort study. Results of the first ABO type obtained in adult, non–type O recipients (i.e., types A, B, AB) after receiving at least one unit of uncrossmatched type O erythrocyte-containing product(s) for any bleeding etiology were analyzed along with the number of uncrossmatched type O erythrocyte-containing products administered in the prehospital and/or in hospital setting before the first type and screen sample was drawn.

Results
There were 10 institutions that contributed a total of 695 patient records. Among patients who received up to 10 uncrossmatched type O erythrocyte-containing products, the median A antigen agglutination strength in A and AB individuals on forward typing (i.e., testing the recipient’s erythrocytes for A and/or B antigens) was the maximum (4+), whereas the median B antigen agglutination strength among B and AB recipients of up to 10 units was 3 to 4+. The median agglutination strength on the reverse type (i.e., testing the recipient’s plasma for corresponding anti-A and -B antibodies) was very strong, between 3 and 4+, for recipients of up to 10 units of uncrossmatched erythrocyte-containing products. Overall, the ABO type of 665 of 695 (95.7%; 95% CI, 93.9 to 97.0%) of these patients could be accurately determined on the first type and screen sample obtained after transfusion of uncrossmatched type O erythrocyte-containing products.

Conclusions
The transfusion of smaller quantities of uncrossmatched type O erythrocyte-containing products, in particular up to 10 units, does not usually interfere with determining the recipient’s ABO type. The early collection of a type and screen sample is important.

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