bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pleiotropic eﬀects of ursodeoxycholic acid in patients with non-alcoholic steatohepatitis with impaired glycemic control
Authors: Shipovskaya A. A. , Kurbatova I. V. , Dudanova O. P. 
Published: November 2020

The goal was to determine the eﬀect of ursodeoxycholic acid (UDCA) in non-alcoholic steatohepatitis (NASH) with impaired glycemic control.Materials and methods. 67 patients NASH were examined: prediabetes — 38 (56.7%), type 2 diabetes mellitus 29 (43.3%), men — 39 (58.2%), women — 28 (41.8%), age — 45.1 ± 10.2 years. The UDCA dose was 9.4 ± 2.0 mg / kg / day during 59.7 ± 77.6 weeks. Fragments of cytokeratin-18 (FCK-18) (TPS ELISA, Biotech, Sweden), TNF-α (Human TNFα Platinum ELISA, eBioscience, Austria), IL-6 (“Interleukin-6-IFA-Best”, Vector-Best, Russia), insulin (“Insulin TEST System”, Monobind Inc., USA), HOMA-IR were determined.Results. There was a decrease in the levels of FCK-18 — from 238.1 ± 93.7 to 170.7 ± 79.2 U / l (p <0.05), ALT — 61.3 ± 19.0 to 38.9 ± 19.1 U / l (p <0.05), glucose 5.9 ± 1.3 to 5.5 ± 0.7 mmol / l (p <0.05), insulin 21.9 ± 18.2 to 13.7 ± 9.7 MkU / l, HOMA-IR — 5.8 ± 2.2 to 3.1 ± 0.8 (p <0.05), cholesterol — 6.2 ± 0.9 to 5.3 ± 0.3 mmol / l, LDL — 3.9 ± 0.9 to 3.2 ± 0.6 mmol / l (p <0.05), TNF-α 6.3 ± 1.5 to 5.4 ± 2.1 pg / ml (p <0.05), IL-6–7.1 ± 3.4 to 4, 1 ± 3.2 pg / ml (p <0.05).Conclusion. UDCA had pleiotropic eﬀects in NASH with impaired glycemic control, reducing cellular apoptosis, necrosis, inﬂammation, improving insulin sensitivity and lipid homeostasis.
Type II achalasia. What can be hidden behind panesophageal pressurization?
Authors: Smirnov A. A. , Kiriltseva M. M. , Lubchenko M. E. 
Published: November 2020

The aimwas to investigate features of manometric pattern of type II achalasia.Materials and methods: High-resolution esophgeal manometry (HRM) was performed in 250 patients with achalasia. In 154 cases patients underwent peroral esophageal myotomy (POEM).Results: We found that poor results after POEM showed patients with high preoperative esophageal pressurization (>80 mm Hg). The poorest result after POEM we observed in patient with short additional increase of panesophageal pressure (up to 95 mm Hg) withing the contour of panesophageal pressurization.
L’effectuation, une logique d’action pertinente pour les managers africains
Authors: Oruezabala Par Gwenaëlle 
Published: November 2020

Cet entretien avec Saras Sarasvathy a eu lieu en face à face le 21 novembre 2019 à Paris. Nous avons abordé le contexte africain et ses spécificités. Il est apparu au cours de cet entretien que ses recherches sur la théorie de l’effectuation et sur la mise en œuvre de concepts, de pratiques et de dispositifs aisément mobilisables sur le terrain sont particulièrement adaptées pour les managers africains, même si à l’origine les terrains de Sarasvhaty n’étaient pas explicitement centrés sur l’Afrique. Elle souligne la puissance de « l’agir » et la « force » de la motivation de l’entrepreneur. Elle insiste notamment sur les effets (effectuation) des projets plutôt que sur les causes, projets qui par leur simple déploiement ont la capacité à mobiliser un grand nombre de ressources locales et frugales.
Pemanfaatan Cangkang Telur Puyuh Sebagai Pengikat Logam Berat Timbal (Pb) dalam Air
Authors: Moelyaningrum Anita Dewi 
Published: November 2020

Timbal (Pb) adalah logam berat yang bersifat toxic. Pb dapat membahayakan lingkungan dan kesehatan organisme. Beberapa limbah bahan organic memungkinkan digunakan sebagai pengikat logam berat. Cangkang telur puyuh mengandung CaCO3 sebesar 55,46%, sehingga memungkinkan untuk dijadikan adsorben untuk menyerap logam berat seperti Pb. Tujuan penelitian ini untuk menganalisis perbedaan kadar Pb pada air yang tidak diberi limbah serbuk cangkang telur puyuh yaitu 0 gr/l (P0) dan diberi perlakuan serbuk cangkang telur puyuh teraktivasi termal pada suhu 800°C dengan variasi massa 1,5 g/l (P1),3,5 g/l (P2), dan 5,5 g/l. Selanjutnya, dilakukan pengadukan menggunakan Jar Test dengan kecepatan 250 rpm selama 10 menit dan didiamkan selama 30 menit. Penelitian ini merupakan penelitian adalah True Experiment dengan Rancangan Acak Lengkap. Data dianalisis menggunakan uji One Way Anova dengan α = 0,05. Hasil menunjukkan bahwa terdapat perbedaan signifikan antara kelompok kontrol dengan kelompok perlakuan (p-value< 0,0001). Perbedaan paling signifikan terjadi pada kelompok penambahan serbuk cangkang telur puyuh teraktivasi sebanyak 5,5 g/l (P3) memiliki penurunan tertinggi dari pada kelompok lainnya yaitu dengan persentase 85,71 %. Cangkang telur puyuh dapat mengikat cemaran timbal (Pb) dalam air.
Comportamiento productivo y características físicas de huevo producido por gallinas criollas Copetonas y Marans
Authors: Rodríguez-Ortega Leodan T. , Rodríguez-Ortega Alejandro , Hernández-Guzmán Filogonio J. , Callejas-Hernández Judith , Pro-Martínez Arturo , Leyva Jimenez Hector 
Published: November 2020

Objective: The present study was conducted to evaluate the productive performance and egg physical characteristics of two backyard-type breeds of birds.
Design/methodology/approach: Tufted Creole Hens (TCH; 13 hens and a rooster) and Marans (13 hens and a rooster), were used in this study. Live body weight, feed intake, egg production, egg weight, egg length and egg width were measured weekly during eight weeks. Collected data were analyzed using a two-way analysis of variance, the main factors were breed, week and their interaction.
Results: Marans hens were heavier and had higher feed intake than the TCH (P<0.05). The egg of the TCH was smaller (P <0.05) in weight and length with respect to that of Marans hens. TCH produced more eggs than the Marans hens (P <0.05). The week factor was significant (P <0.05) for body weight, feed intake and egg length.
Limitations on study/implications: Further studies should be carried out to design a feeding program that would allow both breeds to express their full productive potential and maximize the return on investment in backyard production systems in Mexico.
Findings/conclusions: Marans hens are a heavier breed due to their greater live body weight and feed intake with respect to TCH. The TCH are lighter birds but with a higher egg production when compared to the Marans.
Sujetos de la Reforma: Condiciones institucionales para la implementación de la RS
Authors: Loya Ortega Carmen Griselda 
Published: November 2020

Para efectos del presente artículo se toma como unidad de análisis las características de los sujetos que encabezan las escuelas de nivel secundaria (directores y subdirectores) y una breve reseña respecto de las condiciones institucionales que existen para implementar la reforma en este nivel en la ciudad de Chihuahua, específicamente la caracterización del personal que integra las escuelas de este nivel. La información que se presenta forma parte de una investigación más amplia cuyo propósito fue indagar sobre la reforma y los cambios que se generan durante su implantación en las percepciones, intereses y expectativas de quienes encabezan las escuelas secundarias. El estudio se planteó como un seguimiento en tres momentos durante los ciclos escolares 2006-2007 y 2007-2008; se trata de una investigación enmarcada en el paradigma cualitativo bajo el enfoque del interpretacionismo simbólico con la inclusión de elementos cuantitativos que nos permiten caracterizar ampliamente a los sujetos participantes. Sobre esa base se intenta develar los significados que los individuos construyen en función de sus interacciones con los sujetos que integran las instituciones y el propio fenómeno de la reforma. Se analiza el proceso que sigue la perspectiva de los directivos en los tres momentos del estudio y se obtienen resultados que reflejan avance en el conocimiento de algunos de los factores institucionales que se ven inmersos en el proceso de implantación de la reforma.
Zastosowanie techniki eksploracji procesów i metody obserwacji ukrytej w analizie procesu obsługi posprzedażnej na przykładzie sektora motoryzacyjnego
Authors: Sliż Piotr 
Published: November 2020

Celem artykułu jest przedstawienie wyników analizy przebiegu pre-sales procesu
obsługi klienta posprzedażnego na przykładzie 67 autoryzowanych stacji obsługi
samochodów osobowych w Polsce. Realizacji celu głownego przyporządkowano cele
cząstkowe przecinające się w dwóch płaszczyznach: teoriopoznawczej (TA) i
empirycznej (EA). TA: Przedstawienie koncepcji i przebiegu procesu badawczego z
wykorzystaniem obserwacji ukrytej i process mining EA1: Odtworzenie przebiegu i
analiza pre-sales procesu obsługi klienta posprzedażnego w sektorze
motoryzacyjnym. W realizacji badania wykorzystano następujące metody badawcze:
ilościową analizę bibliometryczną, systematyczny przegląd piśmiennictwa,
obserwację ukrytą i eksplorację procesów (proces mining). W realizacji badania
wykorzystano język programowania R, programy Celonis oraz BOC Adonis. Koncepcja
oceny z wykorzystaniem połączenia process-mining i obserwacji ukrytej, stanowi
dodatkowy głos w dyskusji związanej z możliwościami wykorzystania process
mining w oparciu o rzeczywiste zdarzenia generowane w badanych organizacjach.
Jednocześnie zaproponowane podejście może niwelować błędy, wynikające z
subiektywnej oceny respondentów w sondażowym badaniu opinii. Proponowane
podejście umożliwia ocenę organizacji bez konieczności udostępniania danych dotyczących
przebiegu działań w organizacji. Bariery wynikające z przyjętej koncepcji
dotyczą w szczególności ograniczenia badania do autoryzowanych stacji obsługi
samochodów należących do jednego koncernu.
Assessment of Gingival Biotypes in Patients Visiting a Tertiary Care Centre in Eastern Nepal
Authors: Shrestha Sajeev , Goel Khushboo , Niraula Surya Raj 
Published: November 2020

Background: Evaluation of gingival biotype has become a routine procedure in periodontal examination because the type of gingival biotype can positively or negatively affect the outcome of periodontal, restorative, orthodontic and implant therapy. The aim of the study was to assess the proportion of types of gingival biotypes in patients visiting a tertiary care center in eastern Nepal.
Methods: Two hundred and fifty patients between 25 to 45 years attending the Periodontology and Oral Implantology were assessed. Gingival biotype of the patents was determined with Probe Transparency technique
Results: Out 250 patients assessed, 73 patients (approximately 29.2 %) had thin gingival biotype and remaining 177 patients (approximately 70.8 %) had thick gingival biotype. The number of the male with thin biotype was 31 whereas the number of the male with thick biotype was 82. Similarly, out of 137 female, 42 had thin biotype and remaining 95 female had thick biotype. The types of biotypes were not associated with gender (p=0.67).
Conclusions: Thicker gingival biotype was the more common type of gingival biotype in patients attending the tertiary care center of Eastern Nepal. The occurrence of thick gingival biotype was more common in Adivasi Janajati ethnic community compared to Brahmin / Chhetri ethnic community.
Keywords: Adivasi janajati; gingival biotype, probe transparency technique
Association of Backpack Weight with Musculoskeletal Status among Adolescents
Authors: Kafle Sristy 
Published: November 2020

Background: Adolescence period is a critical stage of musculoskeletal development and carrying heavy backpack to school daily puts them at risk of musculoskeletal discomfort. This study aims to find out the association of backpack weight with musculoskeletal status among adolescents.
Methods: A descriptive cross-sectional study was conducted among 291 grade 4 to 8 students from three government schools of Lalitpur. Data was analyzed using descriptive and inferential statistics.
Results: Around 68% of the adolescents carried schoolbag of weight greater than 10% of their body weight. Similarly, 66.7% perceived musculoskeletal pain of which 29.9% had ever missed school due to pain, 70.1% felt tired while carrying their schoolbag and 23.4% adopted forward/sideways leaning posture while carrying their schoolbag. Age (p< 0.001), backpack percentage to body weight (p< 0.001) and perceived weight of schoolbag (p= 0.006) were significantly associated with musculoskeletal pain. Similarly, age (p= 0.023), sex (p= 0.005), grade (p= 0.030) and perceived weight of schoolbag (p= 0.007) were significantly associated with tiredness while carrying schoolbag. Also, backpack percentage to body weight (p= 0.008), duration of carrying schoolbag (p= 0.010) and perceived weight of schoolbag (p= 0.001) were significantly associated with posture assumed while carrying schoolbag.
Conclusions: Students carrying backpack weight more than recommended limit are more likely to develop musculoskeletal pain and change in posture while carrying their schoolbag. Thus, necessary steps must be taken to further analyze the situation and develop management strategies on reducing backpack weight and its possible effect on adolescents.
Keywords: Adolescents; backpack weight; musculoskeletal pain; tiredness, fatigue
Comparison of Proton Pump Inhibitor and Triple Therapy Regimen for Laryngospharyngeal Reflux Disease
Authors: Pokharel Apar , Mayya Jaya Prakash , Upadhyay Hari Prasad 
Published: November 2020

Background: Laryngopharyngeal reflux is retrograde flow of contents of the stomach to the larynx and the pharynx. The study aims to compare two regimens (proton pump inhibitor monotherapy versus triple therapy) on the outcome of Helicobactor pylori positive laryngopharyngeal reflux disease.
Methods: The presence of laryngopharyngeal reflux was determined by reflux symptom index and reflux finding score. The presence of Helicobactor pylori in the tissue was confirmed by rapid urease test. All urease test negative laryngopharyngeal reflux patients were given a course of proton pump inhibitors and results were evaluated. All urease test positive patients were divided into two groups. One group was given a course of proton pump inhibitors and another group was given a course of triple therapy and the results were compared.
Results: A total number of 704 laryngopharyngeal reflux patients were screened for urease test. Among them 138 patients (19.6 %) were urease test negative and were given proton pump inhibitor therapy. Improvement in both reflux finding score (average score 11.75) and reflux symptom index (average score 5.25) score was observed after 3 months with p-value<0.05. In urease test positive patients, improvement in scores was observed in both proton pump inhibitors and triple therapy group, however marked improvement in the clinical features was observed in triple therapy group with p-value<0.05.
Conclusions: The study reveals association between laryngopharyngeal reflux and Helicobactor pylori. Proton pump inhibitor therapy is sufficient if no Helicobactor pylori is detected, however incase of presence of Helicobactor pylori, triple therapy gives better results.
Keywords: Helicobacter pylori; laryngopharyngeal reflux disease; rapid urease test
Serious Injury and its Correlates among School Going Adolescents in Nepal: A cross-sectional study
Authors: Pandey Achyut Raj , Neupane Tamanna , Chalise Binaya , Chaudhary Sabina , Shrestha Niraj , Bista Bihungum 
Published: November 2020

Background: Injury-related mortality and morbidity, a leading cause of death and disability worldwide, is common among adolescents. However, there is insufficient information on the status and factors responsible for injury among adolescents in Nepal. Hence, the paper estimates the injury prevalence and identify the factors associated with it among adolescent Nepalese students.
Methods: This study used national representative cross-sectional data of the Global School-based Student Health Survey 2015. Complex sample analysis was performed after adjusting the selection probability of each sample participants to identify the correlates of injury among 6529 students of 68 schools in Nepal.
Results: Out of 6529 study participants, 62.79% reported severe injury. The most common injury type was cut or stab wound (67.61%) followed by broken bone/dislocated joints (11.03%) and the most common cause of injury was fall (56.40%). Serious injury was significantly associated with a physical attack (AOR=1.54, CI=1.17-2.04), being involved in a physical fight (AOR=1.62, CI=1.2-2.2), being bullied (AOR=2.73, CI=2.25-3.31), feeling unsafe at school (AOR=1.53, CI=1.23-1.91), helmet use(never/rarely/sometimes) while driving a motorbike (AOR=1.69, CI=1.21-2.38) and drink and drive(AOR=2.28, CI=1.05-4.96).
Conclusions: This study reported the injury as a significant public health concern in Nepal associated with several factors like physical attack, being involved in a physical fight, being bullied, feeling unsafe at school, helmet use while driving motorbike and drink and drive. The high prevalence of injury in Nepal suggests the application of appropriate prevention strategies.
Keywords: Adolescents; injury; Nepal
Economic Evaluation of Oral Alendronate Therapy for Osteoporosis in Chinese Postmenopausal Women: The Impact of Medication Compliance and Persistence
Authors: You Ruxu , Liu Zijie 
Published: November 2020

Objective: Prevalence of osteoporosis in Chinese postmenopausal women has significantly increased over the past decade and oral bisphosphonates are the most potent antiresorptive drugs. The purpose of the present research was to evaluate the cost-effectiveness of oral alendronate for individuals with osteoporosis. We also assessed the impact of medication compliance and persistence on economic outcomes of alendronate and potential economic evaluations of persistence-enhancing interventions.Methods: We constructed an individual-level state-transition model to project health outcomes and costs of oral alendronate for Chinese postmenopausal osteoporotic women. The impact of medication compliance and persistence on economic evaluation was addressed in various scenario analyses. Model inputs were derived from clinical trials and published sources, where available. Deterministic and probabilistic sensitivity analyses were conducted to explore the impact of uncertainties and assumptions on the cost-effectiveness results.Results: Compared with no treatment, alendronate treatment was associated with an additional 0.052 QALYs (quality-adjusted life-years) at an additional cost of USD 738, which yielded an incremental cost-effectiveness ratio (ICER) of USD 14,192.308/QALY. The ICER for the different scenarios (full compliance, full persistence, and both full persistence and full compliance) was USD 4,933.333/QALY, USD 3,006.849/QALY, and USD 2,049.822/QALY, respectively. One-way sensitivity analysis showed the ICER was most sensitive to variations in time horizon and residual effect. Probabilistic sensitivity analysis demonstrated that, at a willingness to pay of USD 29,340/QALY, the probability that oral alendronate therapy will be cost-effective is approximately 80%.Conclusion: The findings support the view that oral alendronate is cost-effective for the treatment of osteoporotic fractures in Chinese postmenopausal women. Medication persistence is found to have a greater impact on cost-effectiveness than compliance and interventions to improve persistence to be an efficient use of resources.
Two New Small-Leaved Species of Casearia (Salicaceae) from Madagascar
Authors: Applequist Wendy L. , Gates Marquise T. 
Published: November 2020

Casearia Jacq. (Salicaceae) in Madagascar is in need of taxonomic study. We identify two new species that are endemic to small regions of Madagascar and that, by virtue of their unusually small leaves and other characters, are clearly distinguished from all previously described taxa. Casearia anosyensis Appleq. & M. T. Gates is endemic to a small region near Tôlanaro in the southeast, at low elevations; it is considered to be Endangered by IUCN criteria. Casearia montigena Appleq. & M. T. Gates is found in montane environments in the extreme north, usually at high elevations; its conservation status is uncertain.
Peningkatan Hasil Belajar IPA pada Model Pembelajaran Creative Problem Solving (CPS)
Authors: Harefa Darmawan , Telaumbanua Tatema , Sarumaha Murnihati , Ndururu Kalvintinus , Ndururu Mastawati 
Published: November 2020

Metode penelitian ini adalah metode quasi eksperimen yang bersifat kuantitatif yaitu kelas eksperimen digunakan model Creative Problem Solving sedangkan dikelas kontrol digunakan metode konvensional. Hasil penelitian yang diperoleh bahwa dikelas eksperimen dengan melakukan pretest diperoleh rata-rata hasil belajar 62,65 dan postest diperoleh rata-rata hasil belajar 84,61. Sedangkan dikelas kontrol pada pretest diperoleh rata-rata hasil belajar 64,54 dan postest diperoleh rata-rata hasil belajar 73,70 yang artinya model Creative Problem Solving lebih berpengaruh pada hasil belajar. Kesimpulan penelitian berdasarkan perhitungan uji hipotesis diketahui thitung = 5,216 lebih besar dari ttabel = 1,667 dengan signifikan 5%. Karna thitung ttabel maka Ha diterima dan Ho ditolak yang artinya “ada pengaruh model pembelajaran Creative Problem Solving terhadap hasil belajar kognitif siswa”.
PENERAPAN METODE EXTREME PROGRAMMING PADA SISTEM INFORMASI LAYANAN PERPUSTAKAAN SMP NEGERI 3 NEGARA BATIN BERBASIS WEB MOBILE
Authors: Nurmayanti Nurmayanti , Wijaya Yoga Iman 
Published: November 2020

Perpustakaan didirikan sebagai syarat untuk memenuhi kebutuhan informasi dalam bentuk media cetak yang bisa di akses oleh semua orang khususnya di lingkungan pendidikian. Ada bermacam-macam jenis perpustakaan yang ada, salah satunya adalah perpustakaan sekolah. Perpusatakaan sekolah sendiri merupakan fasilitas yang dapat digunakan untuk menyimpan segala informasi mengenai dunia pendidikan, ilmu pengetahuan dan memberikan jasa informasi dalam bentuk layanan perpustakaan kepada siswa-siswi dilingkungan sekolah.
Dalam kasus ini perpustakaan di sekolah menengah petama Negeri 3 Negara Batin masih banyak ditemukan beragam masalah yang bisa menghambat segala peroses pelayanan terhadap siswa-siswi. Dengan masih ditemukannya maslah dalam pengololaan data admisnistrasi pada perpustakaan SMP N 3 Negara Batin maka diciptakan suatu perangkat lunak yang bisa memberi solusi untuk membantu petugas perpustakaan dalam mengelola data administrasi perpustakaan SMP N 3 Negara Batin. Seharusnya di era globalisasi ini perpustakaan yang ada di sekolah-sekolah khusunya sekolah yang berada di pelosok dapat juga memanfaatkan sistem informasi sebagai srana dan prasarana untuk menujang kegiatan belajar mengajar.
Dengan pengembangan sistem informasi perpustakaan berbasis web menggunakan metode Extreme Programming (XP)ini, diharapkan dapat memberi solusi untuk meningkatkan peroses pelayanan dan kinerja petugas perpustakaan dalam hal pengelolaan data administrasi pwerpustakaan serta mempercepat transaksi peminjaman dan pengembalian buku oleh siswa-siswi SMP N 3 Negara Batin.