bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eye gaze and facial displays of emotion during emotional film clips in remitted patients with bipolar disorder
Authors: Kjærstad Hanne Lie , Jørgensen Caroline Kamp , Broch-Due Ingrid , Kessing Lars Vedel , Miskowiak Kamilla 
Published: February 2020

Abstract

Background.
Aberrant emotional reactivity is a putative endophenotype for bipolar disorder (BD), but the findings of behavioral studies are often negative due to suboptimal sensitivity of the employed paradigms. This study aimed to investigate whether visual gaze patterns and facial displays of emotion during emotional film clips can reveal subtle behavioral abnormalities in remitted BD patients.

Methods.
Thirty-eight BD patients in full or partial remission and 40 healthy controls viewed 7 emotional film clips. These included happy, sad, and neutral scenarios and scenarios involving winning, risk-taking, and thrill-seeking behavior of relevance to the BD phenotype. Eye gaze and facial expressions were recorded during the film clips, and participants rated their emotional reactions after each clip.

Results.
BD patients showed a negative bias in both facial displays of emotion and self-rated emotional responses. Specifically, patients exhibited more fearful facial expressions during all film clips. This was accompanied by less positive self-rated emotions during the winning and happy film clips, and more negative emotions during the risk-taking/thrill-related film clips.

Conclusions.
These findings suggest that BD is associated with trait-related abnormalities in subtle behavioral displays of emotion processing. Future studies comparing patients with BD and unipolar depression are warranted to clarify whether these differences are specific to BD. If so, assessments of visual gaze and facial displays of emotion during emotional film clips may have the potential to be implemented in clinical assessments to aid diagnostic accuracy.
MMR Deficiency is Homogeneous in Pancreatic Carcinoma and Associated with High Density of Cd8-Positive Lymphocytes
Authors: Fraune Christoph , Burandt Eike , Simon Ronald , Hube-Magg Claudia , Makrypidi-Fraune Georgia , Kluth Martina , Büscheck Franziska , Höflmayer Doris , Blessin Niclas Ch. , Mandelkow Tim , Li Wenchao , Perez Daniel , Izbicki Jakob R. , Wilczak Waldemar , Sauter Guido , Schrader Jörg , Neipp Michael , Mofid Hamid , Daniels Thies , Isbert Christoph , Clauditz Till S. , Steurer Stefan 
Published: February 2020

Abstract
Background
Microsatellite instability (MSI) has emerged as a predictive biomarker for immune checkpoint inhibitor therapy. Cancer heterogeneity represents a potential obstacle for the analysis of predicitive biomarkers. MSI has been reported in pancreatic cancer, but data on the possible extent of intratumoral heterogeneity are lacking.

Methods
To study MSI heterogeneity in pancreatic cancer, a tissue microarray (TMA) comprising 597 tumors was screened by immunohistochemistry with antibodies for the mismatch repair (MMR) proteins MLH1, PMS2, MSH2, and MSH6.

Results
In six suspicious cases, large section immunohistochemistry and microsatellite analysis (Bethesda panel) resulted in the identification of 4 (0.8%) validated MSI cases out of 480 interpretable pancreatic ductal adenocarcinomas. MSI was absent in 55 adenocarcinomas of the ampulla of Vater and 7 acinar cell carcinomas. MMR deficiency always involved MSH6 loss, in three cases with additional loss of MSH2 expression. Three cancers were MSI-high and one case with isolated MSH6 loss was MSS in PCR analysis. The analysis of 44 cancer-containing tumor blocks revealed that the loss of MMR protein expression was always homogeneous in affected tumors. Automated digital image analysis of CD8 immunostaining demonstrated markedly higher CD8 + tumor infiltrating lymphocytes in tumors with (mean = 685, median = 626) than without (mean = 227; median = 124) MMR deficiency (p < 0.0001), suggesting a role of MSI for immune response.

Conclusions
Our data suggest that MSI occurs early in a small subset of ductal adenocarcinomas of the pancreas and that immunohistochemical MMR analysis on limited biopsy or cytology material may be sufficient to estimate MMR status of the entire cancer mass.
Influence of Additives on Zinc Oxide-Based Dye Sensitized Solar Cells
Authors: Geleta Tesfaye Abebe , Imae Toyoko 
Published: February 2020

Abstract
In order to enhance the power conversation efficiency of dye sensitized solar cells (DSSCs), various trials have been reported. In this work, composites of n-type semiconductors, ZnO and ZrS2 were fabricated in DSSCs. In addition, the effect of addition of carbon dots on them was assessed. When 10 wt% of ZrS2 was mixed with ZnO, the power conversion efficiency achieved 1.6 times of that of ZnO but the coexistence of carbon dots and ZrS2 in ZnO DSSC resulted the decrease of the power conversion efficiency. ZrS2 forms an n-n heterojunction with ZnO and contributes to the fast transfer of electrons to the conductive electrode substrate. Meanwhile, when carbon dots are added to ZnO/ZrS2(10 wt%) DSSC, the electrons generated and transferred to ZrS2 should recombine with holes generated and transferred to photosensitizer. These situations are compared with a composite system of ZnO/carbon dots previously reported and suggest us the selection of preferable combinations of composite DSSCs.
Magnetic resonance imaging assessment of chemotherapy-related adipocytic maturation in myxoid/round cell liposarcomas: specificity and prognostic value
Authors: Crombe Amandine , Sitbon Maxime , Stoeckle Eberhard , Italiano Antoine , Buy Xavier , Le Loarer François , Kind Michèle 
Published: February 2020

Objective:
To investigate the specificity, clinical implication and prognostic value of MRI adipocytic maturation (MAM) in myxoid/round cells liposarcomas (MRC-LPS) treated with neoadjuvant chemotherapy (NAC).

Methods:
Of the 89 patients diagnosed with MRC-LPS at our sarcoma reference center between 2008 and 2018, 28 were included as they were treated with NAC, surgery and radiotherapy. All patients underwent contrast-enhanced MRIs at baseline and late evaluation. A control cohort of 13 high-grade pleomorphic and dedifferentiated LPS with same inclusion criteria was used to evaluate the specificity of MAM in MRC-LPS. Two radiologists analyzed the occurrence of MAM, changes in the tumor architecture, shape and surrounding tissues during NAC. Pathological features of tumor samples were reviewed and correlated with MRI. Metastatic relapse-free survival was estimated with Kaplan–Meier curves and Cox models. Associations between prognostic T1-based delta-radiomics features and MAM were investigated with Student t-test.

Results:
MAM was more frequent in MRC-LPS (p = 0.045) and not specific of any type of chemotherapy (p = 0.7). Regarding MRC-LPS, 14 out of 28 patients (50%) demonstrated MAM. Eight patients showed metastatic relapses. MAM was not associated with metastatic relapse-free survival (p = 0.9). MAM correlated strongly with the percentage of histological adipocytic differentiation on surgical specimen (p &lt; 0.001), which still expressed the tumor marker NY-ESO-1. None of the prognostic T1-based delta-radiomics features was associated with MAM.

Conclusion:
MAM seems a neutral event during NAC.

Advances in knowledge:
MAM predominated in MRC-LPS and was not specific of a type of chemotherapy. Occurrence of MAM was not associated with better patients’ metastasis free survival.
Wellbeing Wednesdays: nurse-led clinic for improving physical health care in a general adolescent inpatient unit
Authors: Mellor Catriona , Blackman Jonathan , Barker Emily , Bhula Zaakirah , Sibanda Evelyn , Rawlings Emma , Harrington Della , Combe Gillian 
Published: February 2020

Background: Young people with mental illness are at high risk of physical health complications. Physical healthcare on a general adolescent inpatient unit is complex. Aim: To establish a wellbeing clinic to improve efficiency and quality of the physical healthcare offered and increase health promotion. Methods: Plan, Do, Study, Act (PDSA) cycles were used to drive this quality-improvement project. The authors audited 12 records before establishing the clinic and 12 at three further time points (6, 18 and 30 months post-intervention) to guide changes. Results: Results progressively improved over PDSA cycles. Time taken for initial investigations dropped. Compliance with medication monitoring and management of important physical health domains rose from zero in some cases to 100% in all but one area. Conclusions: Establishing a dedicated physical health clinic in this setting is feasible and leads to improved performance against local and national standards. Mental health teams need to ensure physical health is prioritised.
Experimental synthesis of partially coherent sources
Authors: Wang Rui , Zhu Shijun , Chen Yikai , Huang Hongkun , Li Zhenhua , Cai Yangjian 
Published: February 2020

A flexible pseudo-mode sampling superposition method for synthesizing partially coherent sources has been introduced that can be thought of as an approximate discrete representation of Gori’s nonnegative definiteness criterion for designing spatial correlation functions. Importantly, without performing formidable mode analysis, this method enables us to develop a convenient and efficient experimental technology to customize partially coherent sources without sacrificing theoretical accuracy. As an example, we experimentally generate a new, to the best of our knowledge, class of nontrivial pseudo-Schell model sources recently proposed by de Sande et al. Our approach opens up a useful avenue for manipulating nontrivial partially coherent beams and promotes applications for optical tweezers and photolithography.
Czy dwujęzyczność sprzyja kreatywności? Doniesienie z badań
Authors: Heryng Justyna , Obrębska Monika 
Published: February 2020

The paper discusses links between bilingualism and creativity. It begins with a theoretical introduction and then presents research results based on the Creative Behaviour Questionnaire KANH–I (Popek 2000) in a group of 107 high school students. The obtained data was used to test group differences between attendees of classes learning German bilingually and their peers following standard curriculum, which yielded no significant results. The correlation analysis between bilingualism and the dimensions of creative behaviour according to KANH–I yielded no significant results as well. Finally, possible explanations of the results are discussed, along with the limitations of the present study.
Mathematical approaches for improving the efficiency of railway transport
Authors: Vojtek Martin , Kendra Martin , Zitrický Vladislav , Široký Jaromír 
Published: February 2020

Abstract
Current business trends push transport companies to improve the efficiency of their entrepreneurial activities, what is closely related to costs reduction and revenues increase. Many transport companies achieve it empirically, but some mathematical algorithms, mainly from operational research, can be used to improve the efficiency of railway transport by finding the optimal solution of specific problems. The paper is focused on using of selected methods from applied mathematics in railway transport. These methods are used mainly for improving the operational efficiency of the transport company, what tends to decrease overall operating costs. Major impact is done by efficient use of railway vehicles and train staff. It can be achieved by optimization as a flow network problem or assignment problem, what is further described in the paper. Mathematical approaches can also positively influence the whole logistic process.
Survey on the current gynaecological approach of ovarian cancer patients: The utility of HIPEC
Authors: Iavazzo Christos , Fotiou Alexandros , Tsiatas M. , Christopoulou Athina , Spiliotis John , Sugarbaker Paul 
Published: February 2020

AbstractBackgroundThe aim of this survey was to acquire an overview of the current management of ovarian cancer with an emphasis on the utility of hyperthermic intraperitoneal chemotherapy (HIPEC).Methods: An email was sent to Oncologists prior to PSOGI International Symposium on Advanced Ovarian Cancer, Athens 11–13 April 2019. Doctors submitted responses on the relevant website. The self-report survey contained 17 questions.ResultsIn total, 467 Medical Oncologists, Surgical Oncologists or Gynaecologic Oncologists were participated and answered to this survey. The resectability of disease was evaluated by laparoscopy from 48.5% of the participants, while 51.5% answered that they stage their patients pre-surgically with the use of CT or MRI. The preferred first intervention in advanced ovarian cancer patients is the neoadjuvant chemotherapy followed by interval cytoreductive surgery (72%). Regarding the use of HIPEC, almost half of the participants answered that there is role of HIPEC use in ovarian cancer patients undergoing interval debulking surgery, while almost 70% answered positively about the utility of HIPEC use in ovarian cancer recurrence. As for the role of lymphadenectomy in advanced ovarian cancer patients, half of the responders answered negatively. Finally, only 25% of the participants responded that they always check the BRCA status of their ovarian cancer patients, despite the possible differentiation of treatment based on the molecular profiling (80%).ConclusionsThe results of this survey indicate the utility of HIPEC in treatment of ovarian cancer patients and the differences in the overall management of ovarian cancer patients in the current clinical practice.
Calcificación vascular arterial detectada en radiografía panorámica digital
Authors: Sthorayca Retamozo Fernando Russbelts , Ruiz García de Chacón Vilma Elizabeth 
Published: February 2020

Sr. Editor.
La calcificación arterial puede ocurrir en la túnica íntima como en la túnica media de los vasos sanguíneos. La primera es parte de la aterosclerosis, que está determinada por la acumulación de placas calcificadas dentro de la luz del vaso sanguíneo. En cuanto a la calcificación de la túnica media o también conocida como arteriosclerosis de Monckeberg, es una enfermedad degenerativa y no inflamatoria que está caracterizada por la calcificación distrófica y el endurecimiento progresivo de las fibras musculares, por lo que el vaso pierde su elasticidad sin obstruir o estrechar su luz 1-3.
Changes on the Labour Market, Methodological Aspects of the Application of Employment and Unemployment Indicators
Authors: Pocius Arūnas 
Published: February 2020

The aim of the article is to reveal the main trends in the national labour market. The main focus of the analysis is on the employment and unemploy­ment rates, used in official statistics. In the paper, certain methodological aspects of the application of key labour market indicators are highlighted, the pe­culiarities of the development of employment statis­tics are reviewed, and the structure of potential hu­man resources and its development opportunities are assessed. This article is more closely linked with offi­cial statistics, and the priority is given to the data of Statistic Lithuania; however, the author also makes use of the Lithuanian Labour Exchange and State So­cial Insurance Fund Board (Sodra) data, which in their own way complement and substantiate the results of the analysis provided in the article.
Weather Derivatives: Usage Possibilities for the Lithuanian Economy
Authors: Kropienė Rūta , Jurgo Gžegož 
Published: February 2020

The impact of weather on many commercial and recreational activities is significant and varies both geographically and seasonally. Many industries, including agriculture, energy, utility, construction, tourism and other businesses, are either favourably or adversely affected by “bad” weather. For this reason, financial markets have devised a relatively new class of instruments, the so-called “weather derivatives”, the first of which were launched in 1996 in the United States. There is a number of factors behind the growth in the weather derivatives market. One of these is the deregulation of energy markets. Another one is that capital and insurance markets have come closer to each other. A weather derivative is the new­est product of the financial derivatives market. It al­lows a market participant to minimise a risk from daily weather fluctuations, while insurance companies sell insurance against catastrophic events.
The main aim of this article is to explore possi­bilities to use weather derivatives for the Lithuanian economy. To reach the aim, the following goals were set: to describe products of weather derivatives and their features and to present the possibilities to use these derivatives in the Lithuanian economy on the basis of an example of temperature derivatives. A hypothesis is made that Lithuanian companies could discover new possibilities for business management through the use of weather derivatives.
The methods used in the paper are as follows: comparative analysis, indexes, regression and correla­tion analysis.
Improving Influenza Vaccination in Hospitalized Children With Asthma
Authors: Foradori Dana M. , Sampayo Esther M. , Fanny S. Aya , Namireddy Meera K. , Kumar Anjali M. , Lo Huay-ying 
Published: February 2020

OBJECTIVES:
Children with asthma are at increased risk of complications from influenza; hospitalization represents an important opportunity for vaccination. We aimed to increase the influenza vaccination rate among eligible hospitalized patients with asthma on the pediatric hospital medicine (PHM) service from 13% to 80% over a 4-year period.

METHODS:
Serial Plan-Do-Study-Act cycles were implemented to improve influenza vaccination rates among children admitted with status asthmaticus and included modifications to the electronic health record (EHR) and provider and family education. Success of the initial PHM pilot led to the development of a hospital-wide vaccination tracking tool and an institutional, nurse-driven vaccine protocol by a multidisciplinary team. Our primary outcome metric was the inpatient influenza vaccination rate among PHM patients admitted with status asthmaticus. Process measures included documentation of influenza vaccination status and use of the EHR asthma order set and a history and physical template. The balance measure was adverse vaccine reaction within 24 hours. Data analysis was performed by using statistical process control charts.

RESULTS:
The inpatient influenza vaccination rate increased from 13% to 57% over 4 years; special cause variation was achieved. Overall, 50% of eligible patients were vaccinated during asthma hospitalization in the postintervention period. Documentation of influenza vaccination status significantly increased from 51% to 96%, and asthma history and physical and order set use also improved. No adverse vaccine reactions were documented.

CONCLUSIONS:
A bundle of interventions, including EHR modifications, provider and family education, hospital-wide tracking, and a nurse-driven vaccine protocol, increased influenza vaccination rates among eligible children hospitalized with status asthmaticus.
Jazz’s little brother
Authors: Pedro Josep 
Published: February 2020

Drawing on ethnographic, archival and analytical research, this article examines the origins of the blues scene in Spain. A complex, heterogeneous period that spans from the 1930s to the 1980s, the origins are explored diachronically in relation to four primary aspects: the reception of blues through the growing jazz scene; the national production of blues and blues-related music within the frameworks of jazz, rock and flamenco; the transformative contributions of foreign musicians and cultural producers; and the ultimate development of specialized blues bands that represent a more ‘purist’ appropriation of blues as an autonomous genre. In this process, the article provides a historical overview and a musical mapping of blues in Spain, revealing its unique contribution to modernity as a meaningful, porous common ground between the hegemonic jazz and rock music cultures.
Advanced maternal age and obstetric outcome
Authors: . Ritu , . Mini 
Published: February 2020

Background: The objective of this study was to compare the adverse obstetric and perinatal outcome of pregnancies in women with advanced maternal age > 35 years with that of younger women in age group 20-34 years.Methods: A retrospective comparative study was carried out in department of obstetrics and gynecology at Adesh Medical College over the period of one year from June 2017 to June 2018. The obstetric and perinatal outcome of 100 women with advanced maternal age (study group) was compared with those of 100 younger women aged 20-34 years (control group).Results: Among antenatal complications, women of advanced maternal age had increased incidence of hypertensive disorder of pregnancy (26.6% versus 4.4%; p = 0.00009) and breech presentation (8.8% versus 1.1%; p = 0.04). The rate of caesarean delivery was significantly higher in advanced maternal age (28.8% versus 17.7%; p = 0.05). In perinatal outcome, older women had significantly higher incidence of perinatal death (7.7% versus 0%; p = 0.01).Conclusions: Thus, from this study, it can be concluded that advanced age women had higher incidence of hypertensive disorder of pregnancies and mal presentation, were more likely to deliver by caesarean section and had increased incidence of perinatal death.
Study of under nutrition among under six years children in Kasturwadi village of disrtict Jalna, Maharashtra
Authors: Kausar Hina M. , Muneshwar Sujata 
Published: February 2020

Background: Malnutrition is a silent emergency. Malnutrition prevents children from reaching their full physical and mental potential. The health of children and youth is of fundamental importance. Without ensuring optimal child growth and development efforts to accelerate economic development significantly will be unsuccessful. Aim of the study was to study the prevalence of undernutrtion among the children under 6 years of age and to determine association of sociodemogrphic factors with undernutrition. Methods: A community based cross-sectional study was conducted in children of under 6 years age living in the rural field practice area of Department of Community Medicine IIMSR, Warudi, Jalna, from January 2018 to December 2018. One ninety eight children were studied for nutritional status, socio-demographic measures were obtained from structured questionnaire and followed by anthropometric assessment using standards methods. Statistical analysis was done by using appropriate statistical test.Results: Study found that 44.79% children were underweight, 47.92% were stunted and 39.58% were wasted. Among sociodemographic factors age, maternal educational, working status and SES class had an impact on nutritional status of child.Conclusions: Prevalence of underweight, stunting and wasting was high in this study, this calls for educating mothers and other caretakers in the family regarding increased nutritional requirements with increasing age for attainment of best possible nutrition and growth in children, targeted short-term strategies addressing underlying risk factors and more long-term poverty alleviation strategies may be needed.