bluuebunny/crossref_metadata_2025_split huggingface dataset:
FAKTOR-FAKTOR YANG MEMPENGARUHI PERKEMBANGAN MOTORIK PADA BALITA USIA 4-5 TAHUN DI TK SISWA HARAPAN CILIWUNG SURABAYA
Authors: Astuti Eny 
Published: September 2020

Perkembangan anak yang optimal tergantung pada berkembangnya kemampuan dan ketrampilan motorik, baik motorik kasar maupun halus. Namun tidak semua balita dapat berkembang seperti yang seharusnya, terkadang ada balita yang lambat atau menyimpang dari kemampuan yang seharusnya dimiliki pada tahapan usianya. Proses perkembangan motorik dipengaruhi oleh beberapa faktor yaitu motivasi belajar anak, pengetahuan ibu, lingkungan pengasuhan, teman sebaya, stimulasi, tingkat gizi. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi perkembangan motorik pada balita usia 4-5 tahun di TK Siswa Harapan Ciliwung Surabaya. Penelitian dilakukan menggunakan metode deskriptif korelatif dengan populasi balita usia 4–5 tahun beserta orang tuanya, yang berjumlah 20 orang. Sampel berjumlah 19 orang yang diambil menggunakan teknik purposive sampling. Teknik analisis data dengan menggunakan distribusi frekuensi dan tabulasi silang. Pengumpulan data dengan menggunakan kuisioner dan lembar DDST. Hasil penelitian menunjukan bahwa faktor-faktor yang mempengaruhi perkembangan motorik pada balita usia 4-5 tahun adalah faktor gizi, faktor lingkungan, dan faktor stimulasi. Sedangkan faktor yang tidak mempengaruhi adalah faktor pengetahuan. Disarankan pihak TK dapat bekerja sama dengan instansi kesehatan untuk meningkatkan peran orang tua dalam memantau perkembangan motorik pada balitanya.
Sleep Hygiene Dengan Gangguan Tidur Remaja
Authors: Purnama Ni Luh Agustini 
Published: September 2020

Tidur merupakan salah satu kebutuhan dasar manusia yang penting untuk pertumbuhan fisik dan perkembangan intelektual. Masa remaja rentang mengalami gangguan tidur. Gangguan tidur yang dialami remaja merupakan dampak dari perilaku sleep hygiene yang buruk. Sleep hygiene ini sangat penting untuk memprediksi kualitas dan kuantitas tidur pada remaja. Penelitian ini betujuan mengidentifikasi hubungan sleep hygiene dengan gangguan tidur remaja. Desain penelitian observasi dengan rancangan cross sectional. Subjek penelitian 80 siswa di SMA Katolik Karitas 3 Surabaya memenuhi kriteria inklusi. Perilaku sleep hygiene dinilai menggunakan kuesioner The Adolescent Sleep Hygiene Scale. Penilaian gangguan tidur pada remaja menggunkan kuesioner SDSC (Sleep Disturbances Scale for Children). Perilaku sleep hygiene dalam aspek koqnitif signifikan berhubungan negative dengan gangguan tidur (ρ=-0,35 p=0,001). Hal ini menunjukkan bahwa semakin baik perilaku sleep hygene dalam aspek kognitif maka semakin menurun skor gangguan tidur. Perilaku sleep hygiene dalam aspek stabilitas tidur berhubungan negatif dengan gangguan tidur (ρ= - 0,358 p=0,001), hal ini berarti semakin baik perilaku hygiene dalam aspek stabilitas tidur maka semakin menurun skor gangguan tidur. Program pendidikan kesehatan di sekolah tentang sleep hygiene efektif perlu dilakukan meningkatkan kualitas tidur masa remaja.
Gambaran Tingkat Pengetahuan Mahasiswa Fisioterapi STIKVINC Tentang Insole Sebagai Alternatif Menurunkan Kadar Gula Darah
Authors: Dwianto Ignasius Heri 
Published: September 2020

Penelitian terdahulu menyatakan bahwa pemakaian insole dengan sudut -10° selama 5 hari terjadi penurunan kadar glukosa darah puasa dan kadar glukosa darah post prandial. Berdasarkan pengamatan peneliti tidak semua mahasiswa fisioterapi tahu tentang insole sebagai alternatif menurunkan kadar gula darah. Penelitian ini mengidentifikasi tingkat pengetahuan (tahu) mahasiswa fisioterapi tentang insole sebagai alternatif menurunkan kadar gula darah. Desain penelitian ini adalah penelitian deskriptif. Populasinya sebanyak 125 responden, dengan sampel yang sesuai kriteria inklusi sebesar 70 responden. Tehnik sampling yang digunakan adalah simple random sampling. Data yang terkumpul, kemudian dilakukan analisa deskriptif proporsi presentase. Hasil penelitian didapatkan mahasiswa fisioterapi 51 responden yang mempunyai pengetahuan cukup (73%), 10 responden (14, %), baik dan 9 responden mempunyai tingkat pengetahuan kurang baik (13%). Hal ini didukung karena tingkat pendidikan responden yang berbeda dan informasi yang didapat juga beragam. Masukan bagi Prodi Fisioterapi tetap meningkatkan pengetahuan dan kesadaran mahasiswa fisioterapi tentang insole sebagai alternatif menurunkan kadar glukosa darah melalui seminar ataupun pelatihan untuk memotivasi kembali mahasiswa fisioterapi meningkatkan pengetahuan.
A prognostic long non-coding RNA-associated competing endogenous RNA network in head and neck squamous cell carcinoma
Authors: Zhang Chengyao , Cao Wei , Wang Jiawu , Liu Jiannan , Liu Jialiang , Wu Hao , Li Siyi , Zhang Chenping 
Published: September 2020

Background
This study aimed to develop multi-RNA-based models using a competing endogenous RNA (ceRNA) regulatory network to provide survival risk prediction in head and neck squamous cell carcinoma (HNSCC).

Methods
All long non-coding RNA (lncRNA), microRNA (miRNA), and mRNA expression data and clinicopathological features related to HNSCC were derived from The Cancer Genome Atlas. Differentially expressed RNAs were calculated using R. Prognostic factors were identified using univariate Cox regression analysis. Functional analysis was performed using GO, KEGG pathways, and PPI network. Based on the results, we derived a risk signature and compared high- and low-risk subgroups using LASSO regression analysis. Survival analysis and the relationship between risk signature and clinicopathological features were performed using log-rank tests and Cox regression analysis. A ceRNA regulatory network was constructed, and prognostic lncRNAs and miRNA expression levels were validated in vitro and in vivo.

Results
A list of 207 lncRNAs, 18 miRNAs and 362 mRNAs related to overall survival was established. Five lncRNAs (HOTTIP, LINC00460, RMST, SFTA1P, and TM4SF19-AS1), one miRNA (hsa-miR-206), and one mRNA (STC2) were used to construct the ceRNA network. Three prognostic models contained 13 lncRNAs, eight miRNAs, and 17 mRNAs, which correlated with the patient status, disease-free survival (DFS), stage, grade, T stage, N stage, TP53 mutation status, angiolymphatic invasion, HPV status, and extracapsular spread. KEGG pathway analysis revealed significant enrichment of “Transcriptional misregulation in cancer” and “Neuroactive ligand-receptor interaction.” In addition, HOTTIP, LINC00460, miR-206 and STC2 were validated in GTEx data, GEO microarrays and six HNSCC cell lines.

Conclusions
Our findings clarify the interaction of ceRNA regulatory networks and crucial clinicopathological features. These results show that prognostic biomarkers can be identified by constructing multi-RNA-based prognostic models, which can be used for survival risk prediction in patients with HNSCC.
Changes in muscle activity during the flexion and extension phases of arm cycling as an effect of power output are muscle-specific
Authors: Chaytor Carla P. , Forman Davis , Byrne Jeannette , Loucks-Atkinson Angela , Power Kevin E. 
Published: September 2020

Arm cycling is commonly used in rehabilitation settings for individuals with motor impairments in an attempt to facilitate neural plasticity, potentially leading to enhanced motor function in the affected limb(s). Studies examining the neural control of arm cycling, however, typically cycle using a set cadence and power output. Given the importance of motor output intensity, typically represented by the amplitude of electromyographic (EMG) activity, on neural excitability, surprisingly little is known about how arm muscle activity is modulated using relative workloads. Thus, the objective of this study was to characterize arm muscle activity during arm cycling at different relative workloads. Participants (n = 11) first completed a 10-second maximal arm ergometry sprint to determine peak power output (PPO) followed by 11 randomized trials of 20-second arm cycling bouts ranging from 5–50% of PPO (5% increments) and a standard 25 W workload. All submaximal trials were completed at 60 rpm. Integrated EMG amplitude (iEMG) was assessed from the biceps brachii, brachioradialis, triceps brachii, flexor carpi radialis, extensor carpi radialis and anterior deltoid of the dominant arm. Arm cycling was separated into two phases, flexion and extension, relative to the elbow joint for all comparisons. As expected, iEMG amplitude increased during both phases of cycling for all muscles examined. With the exception of the triceps brachii and extensor carpi radialis, iEMG amplitudes differed between the flexion and extension phases. Finally, there was a linear relationship between iEMG amplitude and the %PPO for all muscles during both elbow flexion and extension.
Ethno Botanical Survey, Anti-leukemia and Anticlastogenic Potential of Medicinal Plants used for Treatment of Leukemia in Oyo State Nigeria
Authors: Adetutu Adewale, , Owoade Olusoji Abiodun, , Alabi Olanike , Abubakar Fatima Aluko , Oyekunle Olubunmi Simeon 
Published: September 2020

Ethnopharmacological Relevance: Leukemia, a cancer of the blood and bone marrow is responsible for about 222.000 deaths annually. The side effects of chemotherapy in leukemia treatment have necessitated the search for natural products especially medicinal plants as alternative therapy.
Aim: This study surveyed common plants used for treating leukemia in Oyo state, Nigeria and assessed the anti-leukemic and anti-clastogenic activities of fractions of Nymphaea lotus.
Methods: Semi-structured questionnaire (1000) was used to collect the ethnobotanical data among the traditional healers. Leukemia was induced in albino mice with 400 mg/kg body weight of benzene intraperitoneally. Aqueous extracts (120mg/kg/bw), fractions and 5-florouracil (25mg) was administered to mice of different groups. The anti-leukemic, anti-clastogenic, antioxidant, hepatoprotective activities and hematological parameters were determined. N. lotus was subjected to gas-chromatography mass spectroscopy analysis.
Results: The ethnobotanical survey recorded 89 plant species with their local names and parts used in the traditional therapeutic preparations. Seven plants (Pistiastratiotes (2.5%), Nymphaea lotus (1.4%), Piper guineense (1.7%), Securinega virosa (2.5%), Calotropis procera (3.4%), Morinda lucida (2.5%) and Xylopia aethiopica (4.5%) with the highest frequency of citation were selected for anti-leukemic and anti-clastogenic screening. The aqueous extract of N. lotus and M. lucida displayed anti-leukemic potential. M. lucida and X. aethiopica improved the hematological parameters. Ethyl acetate fraction of N. lotus significantly (p<0.05) reduced the number of micronucleated polychromatic erythrocyte in the bone marrow and showed anti-leukemic activity. Fractions of N. lotus restored the hematological parameters and exhibited significant (p<0.05) antioxidant activity. Histological observation revealed improvement in the liver general cyto-architecture of mice treated with ethyl acetate and butanol fractions of N. lotus. Some known compounds were identified in ethyl acetate fraction of N. lotus.
Conclusion: Most of the species tested had some anti-leukemic effect in mice, which to some extent supports their traditional inclusion in herbal preparations for treatment of leukemia. The study also identified potential anti-leukemic compounds in N. lotus extract. The study also identified potential anti-leukemic compounds in N. lotus extract.
A 3D Microfabricated Scaffold System for Unidirectional Cell Migration
Authors: Sunami Hiroshi , Shimizu Yusuke , Denda Junko , Yokota Ikuko , Kishimoto Hidehiro , Igarashi Yasuyuki 
Published: September 2020

AbstractThe present study demonstrates unidirectional cell migration using a novel 3D microfabricated scaffold, as revealed by the uneven sorting of cells into an area of 1 mm × 1 mm. To induce unidirectional cell migration, it is important to determine the optimal arrangement of 3D edges, and thus, the anisotropic periodic structures of micropatterns are adjusted appropriately. The cells put forth protrusions directionally along the sharp edges of these micropatterns, and migrated in the protruding direction. There are three advantages to this novel system. First, the range of applications is wide, because this system effectively induces unidirectional migration as long as 3D shapes of the scaffolds are maintained. Second, this system can contribute to the field of cell biology as a novel taxis assay. Third, this system is highly applicable to the development of medical devices. In the present report, unique 3D microfabricated scaffolds that provoked unidirectional migration of NIH3T3 cells are described. The 3D scaffolds could provoke cells to accumulate in a single target location, or could provoke a dissipated cell distribution. Because the shapes are very simple, they could be applied to the surfaces of various medical devices. Their utilization as a cell separation technology is also anticipated.
Oxygen Vacancy Engineering for Highly Tunable Ferromagnetic Properties: A Case of SrRuO3 Ultrathin Film with a SrTiO3 Capping Layer
Authors: Ko Eun Kyo , Mun Junsik , Lee Han Gyeol , Kim Jinkwon , Song Jeongkeun , Chang Seo Hyoung , Kim Tae Heon , Chung Suk Bum , Kim Miyoung , Wang Lingfei , Noh Tae Won 
Published: September 2020

AbstractOxide heterostructures have great potential for spintronics applications due to their well‐defined heterointerfaces and vast functionalities. To integrate such compelling features into practical spintronics devices, effective control of the magnetic switching behavior is key. Here, continuous control of the magnetic coercive field in SrTiO3/SrRuO3 ultrathin heterostructures is achieved by oxygen vacancy (VO) engineering. Pulsed laser deposition of an oxygen‐deficient SrTiO3 capping layer can trigger VO migration into the SrRuO3 layer while avoiding the formation of Ru vacancies. Moreover, by varying the thickness and growth conditions of the SrTiO3 capping layer, the value of the coercive field (HC) in the ferromagnetic SrRuO3 layer can be continuously tuned. The maximum enhancement of HC at 5 K is 3.2 T. Such a wide‐range tunability of HC may originate from a VO‐induced enhancement of perpendicular magnetic anisotropy and domain wall pinning. This study offers effective approaches for controlling physical properties of oxide heterostructures via VO engineering, which may facilitate the development of oxide‐based functional devices.
Photocatalytic Hydrogen Evolution under Ambient Conditions on Polymeric Carbon Nitride/Donor‐π‐Acceptor Organic Molecule Heterostructures
Authors: Li Kui , Wang Lei , Chen Zhongxin , Yang Xianfeng , Yu Yu‐Xiang , Zhang Wei‐De , Wang Ye , Shi Yumeng , Loh Kian Ping , Xu Qing‐Hua 
Published: September 2020

AbstractEfficient solar‐to‐hydrogen (STH) energy conversion under ambient conditions (room temperature and atmospheric pressure) is important for pursuing scalable solar hydrogen generation. Modification of polymeric carbon nitride (PCN) by conjugated polymers has attracted great attention for improving photocatalytic hydrogen evolution (PHE) performance. However, the limited interfacial junction between PCN and conjugated polymers leads to a low density of free charges, resulting in unsatisfactory PHE activity. Herein, three donor‐π‐acceptor‐structured organic molecules (OMs) with different electron‐donating units (amino,N,N‐diethyl and triphenylamine) and same electron‐accepting unit (benzothiadiazole) are designed to modify PCN to enlarge the interfacial junction. The optimized PHE performance under AM 1.5G simulated sunlight and ambient conditions can maintain as high as 4.63 mmol h−1g−1(the highest record among all the reported PCN‐based photocatalysts to the best of the authors knowledge). The improved performance can be partially attributed to the strong visible light harvesting capability of OMs. Specifically, the triphenylamine unit in the formed type II molecule heterojunctions (MHJ) enables efficient charge separation at the interfacial junction, which prolongs the photogenerated electron lifetime for PHE. The designed MHJ photocatalysts show outstanding PHE performance under ambient conditions, which is highly promising for scalable STH conversion.
Combined Effect of Temperature Induced Strain and Oxygen Vacancy on Metal‐Insulator Transition of VO2 Colloidal Particles
Authors: Gurunatha Kargal L , Sathasivam Sanjayan , Li Jianwei , Portnoi Mark , Parkin Ivan P. , Papakonstantinou Ioannis 
Published: September 2020

AbstractVanadium dioxide (VO2) is a promising material in the development of thermal and electrically sensitive devices due to its first order reversible metal‐insulator transition (MIT) at 68 °C. Such high MIT temperature (TC) largely restricts its widespread application which could be enabled if a straightforward tuning mechanism were present. Here this need is addressed through a facile approach that uses the combined effects of temperature induced strain and oxygen vacancies in bulk VO2 colloidal particles. A simple thermal annealing process under varying vacuum is used to achieve phase transformation of metastable VO2(A) into VO2(M2), (M2+M3), (M1) and higher valence V6O13 phases. During this process, distinct multiple phase transitions including increased as well as suppressed TC are observed with respect to the annealing temperature and varied amount of oxygen vacancies respectively. The latent heat of phase transition is also significantly improved upon thermal annealing by increasing the crystallinity of the samples. This work not only offers a facile route for selective phase transformation of VO2 as well as to manipulate the phase transition temperature, but also contributes significantly to the understanding of the role played by oxygen vacancies and temperature induced stress on MIT which is essential for VO2 based applications.
From Dislocation to Nano‐Precipitation: Evolution to Low Thermal Conductivity and High Thermoelectric Performance in n‐Type PbTe
Authors: Deng Ping‐Yuan , Wang Kuang‐Kuo , Du Jia‐Yu , Wu Hsin‐Jay 
Published: September 2020

AbstractPbTe‐based alloys have been widely used as mid‐temperature thermoelectric (TE) materials since the 1960s. Years of endeavor spurred the tremendous advances in their TE performance. The breakthroughs for n‐type PbTe have been somewhat less impressive, which limits the overall conversion efficiency of a PbTe‐based TE device. In light of this obstacle, an n‐type Ga‐doped PbTe via an alternative thermodynamic route that relies on the equilibrium phase diagram and microstructural evolution is revisited. Herein, a plateau of zT = 1.2 is achieved in the best‐performing Ga0.02Pb0.98Te in the temperature range of 550–673 K. Notably, an extremely high average zTave = 1.01 is obtained within 300 − 673 K. The addition of gallium optimizes the carrier concentration and boosts the power factor PF  =  S2ρ−1. Meanwhile, the κL of Ga‐PbTe reveals a significantly decreasing tendency owing to the defect evolution that changes from dislocation loop to nano‐precipitation with increasing Ga content. The pathway for both the κL reduction and defect evolution can be probed by an equilibrium phase diagram, which opens up a new avenue for locating high zT TE materials.
One‐Step Generation of Core–Gap–Shell Microcapsules for Stimuli‐Responsive Biomolecular Sensing
Authors: Kim Hyejeong , Jo Seong‐Min , Meng Fanlong , Guo Yinzhou , Thérien‐Aubin Héloïse , Golestanian Ramin , Landfester Katharina , Bodenschatz Eberhard 
Published: September 2020

AbstractThe versatile design of stimuli‐responsive microparticles embedding valuable biomolecules has great potential in a variety of engineering fields, such as sensors, actuators, drug delivery, and catalysis. Here, results are reported on thermoresponsive core–gap–shell (TCGS) microcapsules made of poly(N‐isopropylacrylamide) (PNIPAm), which encapsulate hydrophilic payloads in a simple and stable manner. These are realized by a one‐step microfluidic approach using the phase separation of a supersaturated aqueous solution of NIPAm. Various designs of the microcapsules are achieved by individual control of the swelling or by incorporating pH‐responsive comonomers of the inner core and outer shell. The gap, i.e., the space between the inner core and outer shell, can be loaded with cargo‐like nanoparticles. The outer shell can serve as a stimuli‐responsive gateway for the transport of smaller molecules from the external solution. It is shown that the TCGS microcapsules are suitable as temperature controllable glucose sensors and hold promise in the design of controllable enzymatic reactions. The proposed platform provides an avenue for developing a new‐generation of microparticles for diverse and efficient engineering applications.
Aqueous Zinc–Tellurium Batteries with Ultraflat Discharge Plateau and High Volumetric Capacity
Authors: Chen Ze , Yang Qi , Mo Funian , Li Na , Liang Guojing , Li Xinliang , Huang Zhaodong , Wang Donghong , Huang Weichun , Fan Jun , Zhi Chunyi 
Published: September 2020

AbstractTraditional aqueous zinc‐ion batteries (ZIBs) based on ion‐intercalation or surface redox behaviors at the cathode side suffer severely from an unsatisfactory specific capacity and unstable output potential. Herein, these issues are applied to a conversion‐type zinc–tellurium (Zn–Te) battery. Typically, this battery works based on a two‐step solid‐to‐solid conversion with the successive formation of zinc ditelluride (ZnTe2) and zinc telluride (ZnTe). It delivers an ultrahigh volumetric capacity of 2619 mAh cm−3 (419 mAh g−1), 74.1% of which is from the first conversion (Te to ZnTe2) with an ultraflat discharge plateau. Though reported first in a challenging aqueous environment, this Zn–Te battery demonstrates an excellent capacity retention of >82.8% after 500 cycles, which results from the elimination of the notorious “shuttle effect” due to the solid‐to‐solid conversion behaviors. In addition, a quasi‐solid‐state Zn–Te battery is also fabricated, exhibiting superior flexibility, robustness, and good electrochemical performance. This work develops a novel cathode material based on conversion‐type ion‐storage mechanism. The system is attractive due to its ultrastable energy output, which is rarely reported for ZIBs.
Elasticity‐Driven Membrane Budding through Cholesterol Concentration on Supported Lipid Monolayer–Bilayer Junction
Authors: Lee Yeon Kyung , Yu Eui‐Sang , Ahn Dong June , Ryu Yong‐Sang 
Published: September 2020

AbstractMembrane budding is an essential process during various biological activities, such as intercellular communication and transportation of life‐sustaining molecules and signals, which primarily occur with the aid of particular proteins. During such processes, the presence of cholesterol and its assembly into particular domains within the membranes have attracted considerable attention due to their unique characteristics in terms of the regulation of signal activities, membrane fluidity, and hormone production during metabolic pathways. However, despite these crucial roles, the precise mechanisms of their spatiotemporal localization toward specific areas and their physiological roles in membrane budding without the assistance of particular proteins remain unclear. Herein, a model membrane platform is reconstituted with lipid monolayer–bilayer junctions, which facilitate the selective concentration of cholesterol on the lipid monolayer regions. In vitro membrane budding is demonstrated by the remaining vesicles where the lipid monolayer membrane is ruptured. The physicochemical approach to the selective concentration of cholesterol and its consequent membrane vesiculation offer important clues to help understand the underlying mechanisms of cholesterol in the lipid‐driven membrane‐budding process.