bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolutionary dynamics of health food safety regulatory information disclosure from the perspective of consumer participation
Authors: Luo Jun , Chen Tingqiang , Pan Jinnan 
Published: November 2019

AbstractThe “trust” attribute of health food has intensified the serious information asymmetry problem in the health food market. Moreover, it has strengthened the formation and influence of potential or hidden safety risks of health food, bringing huge impacts on social harmony and stability. Therefore, this study builds a model of health food enterprise production and operation and government regulatory information disclosure from the perspective of consumer participation. The study fully considers the government's policy burdens and the degree of consumer response to food safety regulatory information. Moreover, it aims to explore the evolution mechanism of food enterprise production and operation strategies and government regulatory information disclosure strategies and analyze the evolution process of the government behavior in health food safety regulatory information disclosure. The theoretical derivation and simulation analysis found that the more sensitive consumers are to health food safety regulatory information, the more significant the profitability improvement of enterprises producing quality health food, thus urging the government to make an objective and comprehensive disclosure of health food safety regulatory information.
Genomic coamplification of CDK4/MDM2/FRS2 is associated with very poor prognosis and atypical clinical features in neuroblastoma patients
Authors: Amoroso Loredana , Ognibene Marzia , Morini Martina , Conte Massimo , Di Cataldo Andrea , Tondo Annalisa , D'Angelo Paolo , Castellano Aurora , Garaventa Alberto , Lasorsa Vito A. , Podestà Marina , Capasso Mario , Pezzolo Annalisa 
Published: November 2019

AbstractNeuroblastoma (NB) is the most common extracranial malignant tumor of childhood and is characterized by a broad heterogeneity in clinical presentation and evolution. Recent advances in pangenomic analysis of NB have revealed different recurrent chromosomal aberrations. Indeed, it is now well established that the overall genomic profile is important for treatment stratification. In previous studies, 11 genes were shown to be recurrently amplified (ODC1, ALK, GREB1, NTSR2, LIN28B, MDM2, CDK4, MYEOV, CCND1, TERT, and MYC) besides MYCN, with poor survival of NB patients harboring these amplifications being suggested. Genomic profiles of 628 NB samples analyzed by array‐comparative genome hybridization (a‐CGH) were re‐examined to identify gene amplifications other them MYCN amplification. Clinical data were retrospectively collected. We additionally evaluated the association of FRS2 gene expression with NB patient outcome using the public R2 Platform. We found eight NB samples with high grade amplification of one or two loci on chromosome arm 12q. The regional amplifications were located on bands 12q13.3‐q14.1 and 12q15‐q21.1 involving the genes CDK4, MDM2, and the potential oncogenic gene FRS2. The CDK4, MDM2, and FRS2 loci were coamplified in 8/8 samples. The 12q amplifications were associated with very poor prognosis and atypical clinical features of NB patients. Further functional and clinical investigations are needed to confirm or refute these associations.
A model for mobile money services adoption by traders in Uganda
Authors: Malinga Ramadhan B. , Maiga Gilbert 
Published: November 2019

AbstractMobile money services provide benefits for trade such as payment of bills, reduced cost and time for transactions, increased savings options, sales, and convenience. Despite the benefits, adoption and use of mobile money services by traders in Uganda remain low. This paper reports on the results of a study that explore the challenges traders face in using and adopting mobile money services in Uganda. Self‐administered questionnaire was used to collect data from 394 respondents in a survey. A model to support mobile money service adoption by traders is proposed. The proposed model extends the Unified Theory for the Acceptance and Use of Technology. Regression analysis indicated that performance expectancy, social influences, and sensitization constructs significantly influence the behavioural intention of mobile money services adoption for trade. On the other hand, security, effort expectancy did not significantly influence the behavioural intention to adopt mobile money services by traders. The findings further reveal that facilitating conditions influenced use behaviour of mobile money services for trade transactions. The proposed model is flexible and generic and can be utilized in other developing countries with similar contexts as Uganda.
A new synthesis of biologically active pyrroles: Formal synthesis of pentabromopseudilin, bimetopyrol, and several antitubercular agents
Authors: Karimi Sasan , Ma Shuai , Qu Michelle , Chen Biling , Ramig Keith , Greer Edyta M. , Szalda David J. , Neary Michelle C. , Berkowitz William F. , Subramaniam Gopal 
Published: November 2019

AbstractAlthough pyrroles have been synthesized from azido dienes, the corresponding reactions of structurally similar nitrodienes had not been investigated until it became the main focus of this study. This article describes the synthesis of several biologically active pyrroles and mechanistically intriguing results in connection with our new approach using nitrodienes in the presence of Ph3P and a Mo catalyst, bis (acetylaceto)dioxomolybdenum (VI). The final precursor of pentabromopseudilin (PBP), pseudilin, was synthesized in four steps from o‐hydroxycinnamaldehyde. An alternate pathway to PBP proceeded through o‐methylpseudilin, prepared in two steps from o‐methoxycinnamaldehyde. Both starting materials are commercially available. Similarly, bimetopyrol (2‐methyl‐4,5‐bis(p‐methoxyphenyl)pyrrole), a potent anti‐inflammatory, was prepared using the new methodology. The remarkable conversion of nitrodienes 14 and 15 to bimetopyrol highlights the formation of a nitroso or nitrene intermediate. We also established that 14 and 15 interconvert in the presence of ambient light and each converts to bimetopyrol when reacted separately. The wide application of our synthetic methodology includes preparation of several antitubercular and Herpes Simplex 2 (HSV2) agents.
Dysfunctional RNA‐binding protein biology and neurodegeneration in experimental autoimmune encephalomyelitis in female mice
Authors: Salapa Hannah E. , Libner Cole D. , Levin Michael C. 
Published: November 2019

AbstractAltered stress granule (SG) and RNA‐binding protein (RBP) biology have been shown to contribute to the pathogenesis of several neurodegenerative diseases, yet little is known about their role in multiple sclerosis (MS). Pathological features associated with dysfunctional RBPs include RBP mislocalization from its normal nuclear location to the cytoplasm and the formation of chronic SGs. We tested the hypothesis that altered SG and RBP biology might contribute to the neurodegeneration in experimental autoimmune encephalomyelitis (EAE). C57BL/6 female mice were actively immunized with MOG35‐55 to induce EAE. Spinal cords were examined for mislocalization of the RBPs, heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and TAR‐DNA binding protein‐43 (TDP‐43), SGs, neurodegeneration (SMI‐32), T cells (CD3), and macrophages (CD68). In contrast to naive mice, mice with EAE showed SG formation (p < 0.0001) and mislocalization of hnRNP A1 (p < 0.05) in neurons of the ventral spinal cord gray matter, which correlated with clinical score (R = 0.8104, p = 0.0253). In these same areas, there was a neuronal loss (p < 0.0001) and increased SMI‐32 immunoreactivity (both markers of neurodegeneration) and increased staining for CD3+ T cells and IFN‐gamma. These findings recapitulate the SG and RBP biology and markers of neurodegeneration in MS tissues and suggest that altered SG and RBP biology contribute to the neurodegeneration in EAE, which might also apply to the pathogenesis of MS.
Association of insurance type with time course of care in head and neck cancer management
Authors: Itamura Kyohei , Kokot Niels , Sinha Uttam , Swanson Mark 
Published: November 2019

Objectives/HypothesisTo determine differences in time course of care based on major insurance types for patients with head and neck squamous cell carcinoma (HNSCC).Study DesignRetrospective cohort study.MethodsRetrospective study of Health Maintenance Organization (HMO), Preferred Provider Organization (PPO), and Medicare patients with biopsy‐proven diagnosis of HNSCC referred to an academic tertiary center for tumor resection and adjuvant therapy. In addition to patient demographic information and tumor characteristics, duration of chief complaint and the following time points were collected: biopsy by referring physician, first specialty surgeon clinic appointment, surgery, and adjuvant radiation start and stop dates.ResultsThere was a statistically significant increase in time interval for HMO (n = 32) patients from chief complaint to biopsy (P = .003), biopsy to first specialty surgeon clinic appointment (P < .001), and surgery to start of adjuvant radiation (P < .001) compared to that of Medicare (n = 31) and PPO (n = 41) patients. Adjuvant radiation was initiated ≤6 weeks after surgery in 22% of HMO (mean duration of 59 ± 17 days), 48% of Medicare (44 ± 13 days), and 61% of PPO (41 ± 12 days) patients.ConclusionsCompared to PPO and Medicare patients, HMO patients begin adjuvant radiation after surgery later and experience treatment delays in transitions of care between provider types and with referrals to specialists. Delaying radiation after 6 weeks of surgery is a known prognostic factor, with insurance type playing a possible role. Further investigation is required to identify insurance type as an independent risk factor of delayed access to care for HNSCC.Level of Evidence4 Laryngoscope, 130:E587–E592, 2020
Long‐term fertilization alters microbial community but fails to reclaim soil organic carbon stocks in a land‐use changed soil of the Tibetan Plateau
Authors: Li Meng , Wang Guoxi , Kang Xiaoming , Hu Hualing , Wang Yan , Zhang Xiangru , Sun Xiaolei , Zhang Hui , Hu Zhengyi , Xi Beidou 
Published: November 2019

AbstractThe microbial community and soil organic carbon (SOC), which play vital roles in soil fertility and the global C cycle, have been heavily altered due to land‐use changes and long‐term fertilization. However, the effect of long‐term fertilization on the microbial community and SOC in land‐use changed soil is still unclear. In this study, a 26‐year field experiment is conducted to detect the bacterial community and SOC stocks in the soils from meadow grasslands (M), croplands without fertilization (NF), and croplands with fertilization for 13 (F13a) and 26 years (F26a) in the Tibetan Plateau. The results show that land‐use change from meadow grassland to cropland induced a decrease in the SOC stocks of total (TOC), free (FOC) and permanganate‐oxidizable OC (POxC) by 61.8–85.0, 51.1–82.8, and 78.4–95.8%, respectively. Long‐term fertilization increased the SOC stocks by 124.4–419.0%, which was still lower than those in the M soils. In addition, macroaggregates (MAA) and bacterial diversity displayed reductions when the land‐use was changed from grassland to cropland, but they were enhanced after long‐term fertilization. Land‐use change and long‐term fertilization both altered the microbial community. MAA served as a habitat for the microbial community and physical protection for SOC. This may be a key driver of changes in the bacterial community and SOC. This study demonstrates that long‐term fertilization alters the microbial community but fails to restore SOC stocks to the level of uncropped meadow soils. Long‐term fertilization integrated with macroaggregates are required to improve OC sequestration for developing sustainable agriculture and mitigating global climate change.
Effectiveness of native wood strand mulches for land rehabilitation in Iran under experimental conditions
Authors: Kavian Ataollah , Allahi Elham , Ziegler Alan D. , Mohamadi Mohamad Ayob , Zabihzadeh Seyed Majid , Hazbavi Zeinab 
Published: November 2019

AbstractWood‐based mulches are a preferred erosion control material for rehabilitation of degraded lands because they can be made from native wood materials; however, research is needed to verify the effectiveness of new products prior to application. The present study aims to assess the effectiveness of two types of native wood strand mulches from Iran (waste byproducts of Alnus glutinosa and Fagus orientalis working) in reducing runoff, soil loss, and sediment concentration under laboratory conditions. Toward this goal, rainfall simulations were conducted 27 times using a 50 mm hr−1 rainfall during 20‐min experiments on erosion plots with treatments of different cover percentages (bare, 30 and 70%) and strand dimensions (16 and 4 cm in length; 1.5 cm wide). The results showed that all strand applications reduced runoff (>12%), soil loss (>47%), and sediment concentration (>44%) compared to the bare plots. The most effective application treatment was a 70% coverage of the 4‐cm strands of either material (p value < .002). The shorter strands were most effective for all hydrological and erosion variables reductions because they maintained more contact with the soil surface during simulated rainfall and then increased the soil retention potential, whereas the longer strands realigned in the direction of flow, thereby limiting their ability to retard flowing water. The small strands also facilitated the creation of microdams that blocked flow and promoted infiltration. Both materials were deemed effective native erosion control products in degraded sites in the Hyrcanian forests of Iran, particularly when small strands were applied at high cover rates.
Method for solidifying desert sands with enzyme‐catalysed mineralization
Authors: Miao Linchang , Wu Linyu , Sun Xiaohao , Li Xia , Zhang Jizhou 
Published: November 2019

AbstractSandstorms have been recognized as severe natural disasters worldwide and are currently occurring with increasing frequently due to global warming and land desertification. This study aims to mitigate their development and combat erosion caused by sandstorms and wind by improving sand‐surface stability via enzyme‐catalysed mineralization. It is an environment‐friendly method. The novelty of the reported enzymatically induced carbonate precipitation (EICP) lies in the usage of an enzyme catalyst extracted from soybeans. In contrast to the commonly used method of microbial‐induced carbonate precipitation, which is active at room temperatures between 20 and 30°C, EICP achieves high production efficiency at broader temperatures (ranging from 10 to 70°C). Four methods in appendix to EICP were chosen to solidify desert sands at the test site. Polyacrylamide (PAM) is a harmless and nonionic macromolecular flocculating agent, which forms a hydrogel network in desert sands and has a synergistic effect with EICP. An innovative method combined EICP and PAM and was used to solidify desert sand at a field trial site, realizing high‐performance. Solidifying desert sand field tests demonstrated that the solidification strength of EICP+PAM is 6.0–7.0% higher compared with the EICP method alone under identical conditions. This method could obtain higher resistance for strong wind erosion.
Is limnology becoming increasingly abiotic, riverine, and global?
Authors: Lapierre Jean‐François , Heathcote Adam J. , Maisonneuve Philippe , Filstrup Christopher T. 
Published: November 2019

AbstractScientists often debate on the evolving state of their fields and future research directions, but empirical studies on research trends are rare and this limits our capacity to disentangle perceptions from facts within the mass of available data. We used ecological and paleolimnological approaches to assess how the “community” of words most commonly used in limnological studies presented at the Association for the Sciences of Limnology and Oceanography (ASLO) meetings and published in Web of Science have evolved over the last decades. We found that the field of limnology has become increasingly focused on global abiotic research themes, especially in rivers, while there was a decrease in the proportion of organismal studies. We hypothesize that this results from both major influential publications highlighting the importance of framing limnology in a global context and the methodological limitations of organismal studies that prevent data from scaling up as quickly as their abiotic counterparts.
Photo‐Tunable Supramolecular Ultrathin Surfaces for Simultaneous Homeotropic Anchoring and Superfast Switching of Liquid Crystals
Authors: Son Intae , Kim Chunho , Moon Gitae , Lee Jun Hyup 
Published: November 2019

AbstractPhoto‐tunable supramolecular ultrathin surfaces functionalized with a soft ultraviolet (UV) treatment of star‐shaped reactive amphiphiles are fabricated to simultaneously afford homeotropic anchoring of liquid crystals (LCs) and improve the LC switching performance. Photochemically functionalized ultrathin surfaces are generated by cross‐linking star‐shaped amphiphilic monomers in the self‐assembled monolayers with retention of cluster structure under electric field. Since these star‐shaped amphiphiles can construct the close‐packed self‐organized molecular layer with an alkyl brush at the interface between indium tin oxide and LCs through intermolecular hydrogen bonding, they might make elegant alignment surfaces for the homeotropic anchoring of LCs to provide a new type of vertical alignment layer. It is experimentally revealed that supramolecular ultrathin layers with vertical nanopillars form hydrophobic surface, and afford a stable and uniform homeotropic alignment of LCs even in high‐temperature environment. Furthermore, a soft UV irradiation on the self‐assembled ultrathin surfaces under electric field yields superfast responsive cross‐linked ultrathin surfaces with low power consumption compared to conventional polyimide layer. Notably, this controlled methodology offers advantages of simplicity, low‐cost, and scalability in the fabrication of functional alignment surfaces without the need of complex manufacturing steps.
Retrospective Analyses of Commercial Trip Limit Efficacy in the Southeastern USA
Authors: Pulver Jeffrey R. , Stephen Jessica A. , Larkin Michael F. , Gray DiLeone Alisha M. 
Published: November 2019

Abstract
Trip limits are frequently used as a management measure to control or reduce harvest by restricting harvest to a maximum amount. The goal of trip limits is often to lengthen the fishing season relative to the annual catch limit by slowing the landings rate or incentivizing fishers to target another species. Two recent commercial trip limits implemented in the southeastern USA were examined to determine the accuracy of the predicted changes in harvest. For South Atlantic Snowy Grouper Hyporthodus niveatus, analysts accurately predicted the change in landings (weight) that could be expected per trip in response to a trip limit increase but did not account for an increased number of trips early in the fishing season. An increased number of trips resulted in higher landings causing Snowy Grouper to reach the quota and close earlier than desired. For Gulf of Mexico Gray Triggerfish Balistes capriscus, analysts underestimated the predicted change in landings per trip that could be realized from implementing a trip limit (numbers of fish). The Gray Triggerfish analysis failed to account for fishers retaining larger individual fish on average after the trip limit was implemented, resulting in higher landings than predicted. When examining per-fish trip limits, it is recommended that other potential changes in fishing behavior, such as changes in the mean weight of fish being retained or increased effort, be considered. The results of this study could be used to improve the effectiveness of trip limits as a management tool.
The largest caucasian kindred with dentatorubral‐pallidoluysian atrophy: A founder mutation in italy
Authors: Grimaldi Silvia , Cupidi Chiara , Smirne Nicoletta , Bernardi Livia , Giacalone Fabio , Piccione Giuseppina , Basiricò Salvatore , Mangano Giuseppe Donato , Nardello Rosaria , Orsi Laura , Grosso Enrico , Laganà Valentina , Mitolo Micaela , Maletta Raffaele Giovanni , Bruni Amalia Cecilia 
Published: November 2019

AbstractBackgroundDentatorubral‐pallidoluysian atrophy is a hereditary neurodegenerative disease prevalently reported in Japan but rare in Caucasians. The objective of this study was to reconstruct the pedigree of Italian dentatorubral‐pallidoluysian atrophy familial cases describing their clinical features.MethodsWe investigated 6 apparently unrelated dentatorubral‐pallidoluysian atrophy families comprising a total of 51 affected individuals: 13 patients were clinically examined, and for 38 patients clinical data were collected from clinical sources. The dentatorubral‐pallidoluysian atrophy diagnosis was genetically confirmed in 18 patients. Genealogical data from historical archives were analyzed.ResultsAll 6 families were unified in a large pedigree deriving from a founder couple originating from Monte San Giuliano (Italy) in the late 1500s, with 51 affected subjects over the last 4 generations. Wide phenotypical variability in age at onset and clinical features was confirmed. Epilepsy was more frequent in juvenile cases than in late adults, with cognitive/psychiatric and motor disorders observed regardless of age at onset.ConclusionsWe have described the largest Caucasian dentatorubral‐pallidoluysian atrophy pedigree from a single founder couple. The introduction of the dentatorubral‐pallidoluysian atrophy gene in Italy could have arisen as a result of trade relationships between the Spanish or Portuguese and the Japanese in the 1500s. © 2019 International Parkinson and Movement Disorder Society
Habitual Nut Exposure, Assessed by Dietary and Multiple Urinary Metabolomic Markers, and Cognitive Decline in Older Adults: The InCHIANTI Study
Authors: Rabassa Montserrat , Zamora‐Ros Raul , Palau‐Rodriguez Magalí , Tulipani Sara , Miñarro Antonio , Bandinelli Stefania , Ferrucci Luigi , Cherubini Antonio , Andres‐Lacueva Cristina 
Published: November 2019

ScopeThe association between self‐reported dietary intake and urinary metabolomic markers of habitual nut exposure with cognitive decline over a 3‐year follow‐up in an older Italian population is prospectively evaluated.Methods and resultsA total of 119 older participants are selected, based on self‐referred nut intake: the non‐nut consumer (n = 72) and the regular consumer (≥2.9 g d−1, n = 47). Nut exposure is measured at baseline either with the use of a validated food frequency questionnaire or with an HPLC‐Q‐ToF‐MS metabolomic approach. Three years after, 28 from the nonconsumers and 10 from the consumers experienced cognitive decline. Dietary nut exposure is characterized by urinary metabolites of polyphenols and fatty acids pathways. Nut consumption estimated either by the dietary marker or by the urinary marker model is in both cases associated with less cognitive decline (OR: 0.78, 95% CI: 0.61,0.99; p = 0.043 and OR: 0.995, 95% CI: 0.991,0.999; p = 0.016, respectively) with AUCs 73.2 (95% CI: 62.9, 83.6) and 73.1 (62.5, 83.7), respectively.ConclusionsA high intake of nuts may protect older adults from cognitive decline. Metabolomics provides accurate and complementary information of the nut exposure and reinforces the results obtained using dietary information.