bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges and facilitators of hospice decision-making: a retrospective review of family caregivers of home hospice patients in a rural US–Mexico border region—a qualitative study
Authors: Ko Eunjeong , Fuentes Dahlia , Singh-Carlson Savitri , Nedjat-Haiem Frances 
Published: July 2020

ObjectivesHospice care (HC) is seen as a comprehensive approach, that enhances quality of end-of-life (EOL) care, for terminally ill patients. Despite its positive aspects, HC enrolment is disproportionate for rural patients, who are less likely to use HC in comparison to their urban counterparts. The purpose of this study was to explore decision-making experiences, related to utilisation of HC programmes from a retrospective perspective, with family caregivers (FCGs) in a rural US–Mexico border region.DesignThis qualitative study was conducted from May 2017 to January 2018 using semistructured face to face interviews with FCGs. Data were analysed using thematic analysis.SettingThe HC programme was situated at a local home health agency, located in rural Southern California, USA.ParticipantsTwenty-eight informal FCGs of patients who were actively enrolled in the HC programme agreed to participate in the study.ResultsConversation about HC as an option was initiated by home healthcare staff (39.3%), followed by physicians (32.1%). Emerging themes related to challenges in utilisation of HC and decision-making included: (1) communication barriers; (2) lack of knowledge/misperception about HC; (3) emotional difficulties, including fear of losing their patient, doubt and uncertainty about the decision, denial and (4) patients are not ready for HC. Facilitators included: (1) patient’s known EOL wishes; (2) FCG-physician EOL communication; (3) the patient’s deteriorating health and (4) home as the place for death.ConclusionsHC patients’ FCGs in this rural region reported a lack of knowledge or misunderstanding of HC. It is recommended that healthcare providers need to actively engage family members in patient’s EOL care planning. Optimal transition to an HC programme can be facilitated when FCGs are informed and have a clear understanding about patients’ medical status along with information about HC.
Cohort profile: Resettlement in Uprooted Groups Explored (REFUGE)—a longitudinal study of mental health and integration in adult refugees from Syria resettled in Norway between 2015 and 2017
Authors: Nissen Alexander , Cauley Prue , Saboonchi Fredrik , Andersen Arnfinn , Solberg Øivind 
Published: July 2020

PurposeIn the field of forced migration and mental health research, longitudinal studies with large sample sizes and rigorous methodology are lacking. Therefore, the Resettlement in Uprooted Groups Explored (REFUGE)-study was initiated in order to enhance current knowledge on mental health, quality of life and integration among adult refugees from Syria resettled in Norway. The main aims of the study are to investigate risk and protective factors for mental ill health in a longitudinal perspective; to trace mental health trajectories and investigate important modifiers of these trajectories and to explore the association between mental health and integration in the years following resettlement. The aims will be pursued by combining data from a longitudinal, three-wave questionnaire survey with data from population-based registries on education; work participation and sick-leave; healthcare utilisation and drug prescription. The goal is to incorporate the data in an internationally shared database, the REFUGE-database, where collaborating researchers may access and use data from the study as well as deposit data from similar studies.ParticipantsAdult (≥18 years), Syrian citizens who arrived in Norway as quota refugees, asylum seekers or through Norway’s family reunion programme between 1 January 2015 and 31 December 2017. Of the initial 9990 sampled individuals for the first wave of the study (REFUGE-I), 8752 were reached by post or telephone and 902 responded (response rate=10.3%).Findings to dateNone published.Future plansThe REFUGE-cohort study will conduct two additional data collections (2020 and 2021). Furthermore, questionnaire data will be linked to population-based registries after all three waves of data collection have been completed. Registry data will be obtained for time-periods both prior to and after the survey data collection points. Finally, pending ethics approval, we will begin the process of merging the Norwegian REFUGE-cohort with existing datasets in Sweden, establishing the extended REFUGE-database.Trial registration numberClincalTrials.gov Registry (NCT03742128).
Competencies for collaboration between general practitioners and medical specialists: a qualitative study of the patient perspective
Authors: Janssen Marijn , Fluit Cornelia R M G , Sagasser Margaretha H , Kusters Loes H J , Scherpbier-de Haan Nynke D , de Graaf Jacqueline 
Published: July 2020

ObjectivesTo explore the patient view of competencies essential for doctors to provide good collaboration at the primary–secondary care interface.DesignWe used a qualitative research approach. Focus groups with patients were conducted to explore their opinions of doctors’ competencies to provide good collaboration between primary and secondary care doctors. Transcripts were analysed using thematic analysis.SettingDutch primary–secondary care interface.ParticipantsSixteen participants took part in five focus groups. Patients treated in both primary and secondary care, defined as having a minimum of two contacts with their general practitioner and two contacts with a medical specialty in the last 6 months, were included. Psychiatric patients and children were excluded from this study.ResultsThree groups of competencies were identified: (1) relationship building, both with patients and with other doctors; (2) transparent collaborating: be able to provide clarity on the process of collaboration and on roles and responsibilities of those involved and (3) reflective practising: to be willing to acknowledge mistakes, give and receive feedback and act as a lifelong learner.ConclusionsThis focus group study enhances our understanding of the patient perspective on doctors’ collaborative competencies at the primary–secondary care interface. With this information, doctors can improve their collaborative skills to a level that would meet their patients’ needs. Patients expect doctors to be able to build relationships and act as reflective practitioners. Including patients in the collaborative process by giving them a role that is appropriate to their abilities and by making collaboration more explicit could help to improve collaboration between general practitioners and medical specialists.
Impact of COVID-19 pandemic on mental health of young people and adults: a systematic review protocol of observational studies
Authors: Silva Junior Fernando Jose Guedes da , Sales Jaqueline Carvalho e Silva , Monteiro Claudete Ferreira de Souza , Costa Ana Paula Cardoso , Campos Luana Ruth Braga , Miranda Priscilla Ingrid Gomes , Monteiro Thiago Alberto de Souza , Lima Regina Aparecida Garcia , Lopes-Junior Luis Carlos 
Published: July 2020

IntroductionSince the WHO declared COVID-19 as a pandemic, the spread of the new coronavirus has been the focus of attention of scientists, governments and populations. One of the main concerns is the impact of this pandemic on health outcomes, mainly on mental health. Even though there are a few empirical studies on COVID-19 and mental health, so far, there is no systematic review about the impact of COVID-19 on mental health of young people and adults yet. We aim to critically synthesise the scientific evidence about the impact of the COVID-19 pandemic on the mental health of young people and adults.Methods and analysisA systematic review will be performed through eight databases: MEDLINE (Medical Literature Analysis and Retrieval System Online), ISI-of-Knowledge, CENTRAL (Cochrane Central Register of Controlled Trials), EMBASE (Excerpta Medica Database), SCOPUS, LILACS (Latin American and Caribbean Health Sciences Literature), PsycINFO (Psychology Information) and CNKI (Chinese National Knowledge Infrastructure), from inception until 30 June 2020. No restriction regarding the publication date, setting or languages will be considered. Preliminary search strategies were carried out on 29 March 2020 and will be updated in June 2020. The primary outcomes will be the prevalence and the severity of psychological symptoms in young people and adults (>18 years old) resulting from the impact of COVID-19 pandemic. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. Pooled standardised mean differences and 95% CIs will be calculated. The risk of bias of the observational studies will be assessed through the Methodological Index for Non-Randomised Studies (MINORS). Additionally, if sufficient data are available, a meta-analysis will be conducted. Heterogeneity between the studies will be determined by the I2 statistics. Subgroup analyses will also be performed. Publication bias will be checked with funnel plots and Egger’s test. Heterogeneity will be explored by random-effects analysis.Ethics and disseminationEthical assessment was not required. Findings will be disseminated through peer-reviewed publication and will be presented at conferences related to this field.PROSPERO registration numberCRD42020177366.
Association of PTP4A3 expression and tumour size in functioning pituitary adenoma: a descriptive study
Authors: Moyano Crespo Gabriela Deisi , Cecenarro Laura Anahí , Perez Pablo , Guido Carolina , Sosa Liliana del Valle , Berhard Celina , Aballay Laura Rosana , Gutiérrez Silvina , Petiti Juan Pablo , Torres Alicia , Mukdsi Jorge 
Published: July 2020

BackgroundPTP4A3 is a subclass of a protein tyrosine phosphatase super family and is expressed in a range of epithelial neoplasms. We evaluated PTP4A3 expression and its association with clinicopathological parameters in different types of functioning pituitary adenomas.MethodsA total of 34 functioning pituitary adenomas samples were evaluated in this observational study. PTP4A3 expression was examined by immunohistochemical staining, and, possible correlations between PTP4A3 and some clinicopathological variables were investigated.ResultsPTP4A3 was expressed in 19 out of 34 tumours (55%), at the cytoplasmic level of tumorous cells. Moreover, there was significant association (p=0.042) between PTP4A3 expression and tumorous size.ConclusionsPTP4A3 was expressed in more than half of the tumours analysed, with there being a significant association with the tumorous size of functioning adenomas. This allows to speculate that PTP4A3 may regulate tumour growth, although further investigations are necessary to determine if this phosphatase can serve as a biomarker or used as a therapeutic target in pituitary macroadenomas.
Quasinormal modes of three-dimensional rotating Hořava AdS black hole and the approach to thermal equilibrium
Authors: Bécar Ramón , González P. A. , Papantonopoulos Eleftherios , Vásquez Yerko 
Published: July 2020

Abstract
We compute the quasinormal modes (QNMs) of a massive scalar field in the background of a rotating three-dimensional Hořava AdS black hole, and we analyze the effect of the breaking of Lorentz invariance on the QNMs. Imposing on the horizon the requirements that there are only ingoing waves and at infinity the Dirichlet boundary conditions and the Neumann boundary condition hold, we calculate the oscillatory and the decay modes of the QNMs. We find that the propagation of the scalar field is stable in this background and employing the holographic principle we find the different times of the perturbed system to reach thermal equilibrium for the various branches of solutions.
Jet transition values for the anti-$$k_{\bot }$$ algorithm
Authors: Szőr Zoltán 
Published: July 2020

AbstractWe define jet transition values for the anti-$$k_{\bot }$$k⊥ algorithm for both hadron and $$e^+e^-$$e+e- colliders. We show how these transition values can be computed and how they can be used to improve the performance of clusterization when jet resolution parameters are varied over a larger set of values. Finally we present a simple performance test to illustrate the behavior of the new method compared to the original one.
A new formula for conserved charges of Lovelock gravity in AdS space–times and its generalization
Authors: Peng Jun-Jin , Liu Hui-Fa 
Published: July 2020

Within the framework of the Lovelock gravity theory, we propose a new rank-four divergenceless tensor consisting of the Riemann curvature tensor and inheriting its algebraic symmetry characters. Such a tensor can be adopted to define conserved charges of the Lovelock gravity theory in asymptotically anti-de Sitter (AdS) space–times. Besides, inspired with the case of the Lovelock gravity, we put forward another general fourth-rank tensor in the context of an arbitrary diffeomorphism invariant theory of gravity described by the Lagrangian constructed out of the curvature tensor. On basis of the newly-constructed tensor, we further suggest a Komar-like formula for the conserved charges of this generic gravity theory.
The Fire Within: NF-κB Involvement in Non–Small Cell Lung Cancer
Authors: Dimitrakopoulos Foteinos-Ioannis D. , Kottorou Anastasia E. , Kalofonou Melpomeni , Kalofonos Haralabos P. 
Published: July 2020

AbstractThirty-four years since its discovery, NF-κB remains a transcription factor with great potential for cancer therapy. However, NF-κB–targeted therapies have yet to find a way to be clinically translatable. Here, we focus exclusively on the role of NF-κB in non-small cell lung cancer (NSCLC) and discuss its contributing effect on cancer hallmarks such as inflammation, proliferation, survival, apoptosis, angiogenesis, epithelial–mesenchymal transition, metastasis, stemness, metabolism, and therapy resistance. In addition, we present our current knowledge of the clinical significance of NF-κB and its involvement in the treatment of patients with NSCLC with chemotherapy, targeted therapies, and immunotherapy.
COVID-19 Testing in Patients with Cancer: Does One Size Fit All?
Authors: Madariaga Ainhoa , McMullen Michelle , Sheikh Semira , Kumar Rajat , Liu Fei-Fei , Zimmermann Camilla , Husain Shahid , Zadeh Gelareh , Oza Amit M. 
Published: July 2020

Abstract
The COVID-19 global pandemic has drastically impacted cancer care, posing challenges in treatment and diagnosis. There is increasing evidence that cancer patients, particularly those who have advanced age, significant comorbidities, metastatic disease, and/or are receiving active immunosuppressive therapy may be at higher risk of COVID-19 severe complications. Controlling viral spread from asymptomatic carriers in cancer centers is paramount, and appropriate screening methods need to be established. Universal testing of asymptomatic cancer patients may be key to ensure safe continuation of treatment and appropriate hospitalized patients cohorting during the pandemic. Here we perform a comprehensive review of the available evidence regarding SARS-CoV-2 testing in asymptomatic cancer patients, and describe the approach adopted at Princess Margaret Cancer Centre (Toronto, Canada) as a core component of COVID-19 control.
Congenital Heart Disease After the Fukushima Nuclear Accident: The Japan Cardiovascular Surgery Database Study
Authors: Hirata Yasutaka , Shimizu Hideyuki , Kumamaru Hiraku , Takamoto Shinichi , Motomura Noboru , Miyata Hiroaki , Okita Yutaka 
Published: July 2020

Background
In March 2011, the Fukushima Daiichi nuclear power plant disaster inflicted radiation damage across the Tohoku region of Northern Japan. The consequent harm to pregnant mothers and newborns was a matter of concern. We performed a registry‐based analysis of the incidence of congenital heart disease during 2010 to 2013 using the Japan Cardiovascular Surgery Database.

Methods and Results
We selected patients who had complex congenital heart disease and who were born between January 1, 2010 and December 31, 2013 undergoing surgery, and assessed the trend in the number of first‐time surgeries performed for patients aged 2 years and younger by birth year over time. The numbers of first‐time surgeries for birth years 2010 to 2013 were 2978, 2924, 3077, and 2940, and no increasing trend was detected. Additionally, no increasing yearly trend was detected when the number of cases was divided by the total number of births in Japan in each birth month. The mortality of first‐time surgeries performed for complex diseases, which often involves multiple subsequent surgeries, decreased from 4.7% in 2010 to 2.2% in 2013.

Conclusions
Our analyses showed no increase in the number of patients with congenital heart disease during 2010 to 2013. The yearly increase in the total number of surgeries following the Fukushima Daiichi nuclear disaster in a previous report can be explained by the decline in the mortality of first‐time surgeries for complex cases. Such use of only the increase in the total yearly number of surgeries to claim the effects of a nuclear disaster on the incidence of congenital heart disease is a far too simplistic and dangerous proposition.
Thekla’s Epic: Identity and Classicism in the Life and Miracles of Saint Thekla
Authors: Hylen Susan E. 
Published: July 2020

Abstract
In the fifth century, the author of the Life and Miracles of Saint Thekla transformed Thekla’s story from a simple Greek work into a grand epic. He collected stories and rewrote the Acts of Thekla using methods that were similar to other Christian and non-Christian works. The author employed classicizing language and allusions to Homer and other ancient writers in order to convey the high status he deemed appropriate to the story. Like other Christian works, the author rewrote scripture as a way of reinforcing and updating its importance. Through these stylistic features, the Life and Miracles conveys an appreciation for literary education and suggests a context in which reading, writing, and devotion were mutually reinforcing.
A Fragment of a Biblical Cento in the Duke Papyrus Archive (P.Duk. inv. 660)
Authors: Wagner Nicholas E. 
Published: July 2020

Abstract
Editio princeps of P.Duk. inv. 660, a possibly third- or fourth-century papyrus fragment containing a mixture or patchwork (i.e. a cento) of citations of and allusions to the Greek bible: Gen 27:28, Pss 26:2, 4, 41:2, 123:7, and 2 Cor 6:2 are present and a number of other scriptural references are likely. What remains of the papyrus indicates that it held some personal or devotional function.
Blotting Out the Name
Authors: Gordon Nehemia 
Published: July 2020

Abstract
Part 1 of this study considered how the rabbinic prohibition against erasing the Tetragrammaton led to scribes performing diverse procedures to resolve scribal errors. In part 2 it will be shown that special procedures were performed in Torah scrolls, namely, skiving, excision, and removing sheets. Washing off the divine name was not found in the corpus examined. Despite the rabbinic prohibition, medieval Jewish scribes occasionally marked the Tetragrammaton with a strikethrough or erased it through abrasion. This may have been the handiwork of Karaite scribes who did not see themselves bound by the midrashic interpretation of Deut 12:4. The scribes who wrote the Aleppo Codex may have abraded erroneous instances of the Tetragrammaton in order to create a model codex. Scribes in the isolated Jewish community of Kaifeng, who erased erroneous instances of the Tetragrammaton, may not have been familiar with rabbinic strictures.
Choosing Educational Resources to Build Interprofessional, Palliative Care Competency: A Replicable Review Methodology
Authors: Yue Kathleen , Tayler Carolyn 
Published: July 2020

Aim/Objective: The purpose of the project was to provide information to inform the choice of educational resources available in British Columbia to support palliative care competency development for 4 disciplines: nurses, physicians, health care assistants, and social workers/counsellors. This article will describe the process of resource review. Results of the review are available at https://www.bc-cpc.ca/cpc/education-resource-review/ . The objectives were to (1) identify gaps common to all educational resources, (2) provide information on content addressing competencies as well as logistics such as time required, cost, delivery method, and training requirements for instructors, and (3) develop a reproducible process for assessment of educational resources which is unbiased, transparent, and competency based. Method: Sixteen educational resources were assessed for the percentage of competencies that were addressed. Gaps common to all resources were identified. Results: The review process is described and can be replicated when assessing future versions of these and other palliative continuing education courses. This is a reproducible methodology for review of competency-based educational resources which could be applied for any practice-related subject. Conclusion: This review process provided information which can inform a provincial interprofessional palliative education plan. The methodology may be used by others to assess and choose between competency-based education resources with a palliative population focus and other patient population foci.
Temporal Trends in New Registrations for the Ontario Cleft Lip and Palate/Craniofacial Dental Program Between 2007 and 2018
Authors: Ho Jane , Casas Michael 
Published: July 2020

Background: The Ontario Cleft Lip and Palate/Craniofacial Dental Program was established to fund dental care for those with oral clefts, craniofacial anomalies, congenital oral defects, and acquired facial/oral defects. Aim: To determine the annual rates of newly registered oral clefts, craniofacial anomalies, congenital oral defects, and acquired oral defects cases on the Program from 2007 to 2018 and identify trends in registration rates during this time period. Design: Data were obtained from the Program from 2007 to 2018. Annual, age-specific incidence rates (for age groups 0-4, 5-9, 10-14, 15-19, and 20-24 years) were calculated for new registrations in each diagnostic category, plotted and examined using Poisson regression analysis to identify trends. Results: Rates of new registration for oral clefts and acquired oral defects were stable from 2007 to 2018. The rates of newly registered cases of craniofacial anomalies and congenital oral defects showed an increased trend from 2007 to 2018, although year-by-year comparison of the change in rates did not reach statistical significance. For craniofacial anomalies, congenital oral defects, and acquired oral defects, the highest rates of new registrations occurred in the age group 10 to 14 years, while those aged 0 to 4 recorded the highest registration rates in the oral cleft group. Conclusion: Rates in new cleft and acquired oral defects registrations were stable from 2007 to 2018. Rates in newly registered cases of craniofacial anomalies and congenital oral defects increased over the 11-year period.