bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Up-Regulation of HDAC6 Results in Poor Prognosis and Chemoresistance in Patients with Advanced Ovarian High-Grade Serous Carcinoma
Authors: Yano Mitsutake , Miyazawa Mariko , Ogane Naoki , Ogasawara Aiko , Hasegawa Kosei , Narahara Hisashi , Yasuda Masanori 
Published: July 2020

Abstract
Background: Ovarian high-grade serous carcinoma (HGSC) gradually acquires chemoresistance after recurrence. In our previous study on ovarian clear cell carcinoma, histone deacetylase 6 (HDAC6) led to chemoresistance. This study aimed to evaluate HDAC6 as a predictor of chemoresistance and therapeutic target for ovarian HGSC. Methods: We evaluated the clinical significance of HDAC6 as a predictor of prognosis and chemoresistance in HGSC. Immunohistochemical expressions of HDAC6, programmed cell death ligand-1 (PD-L1), and hypoxia inducible factor-1α (HIF-1α) were analyzed using clinical samples from 88 patients with ovarian HGSC. The clinicopathological characteristics were reviewed. Results: Twenty-three patients had high HDAC6 expression; 10, positive PD-L1 expression; and 33, high HIF-1α expression. HDAC6 up-regulation was correlated with not undergoing interval debulking surgery (p < 0.001), incomplete surgical resection (p = 0.002), and frequent occurrence of stable disease/progressive disease according to the RECIST (p = 0.005) criteria. On Kaplan-Meier analysis, high HDAC6 expression was significantly associated with decreased progression-free survival (p = 0.001) and overall survival (p = 0.008). On multivariate analysis, high HDAC6 expression (hazard ratio = 1.65; 95% confidence interval 1.03–2.66, p = 0.039) and surgery status were independent prognostic factors of progression-free survival. PD-L1 and HIF-1α expressions positively correlated with HDAC6. Conclusion: HDAC6 is a potential therapeutic target since HDAC6 up-regulation might cause poor prognosis in patients with ovarian HGSC.
A study and identification of COVID-19 viruses using N-grams with Naïve Bayes, K-Nearest Neighbors, Artificial Neural Networks, Decision tree and Support Vector Machine
Authors: Boujnouni Mohamed El 
Published: July 2020

Abstract
Coronavirus disease 2019 or COVID-19 is a global health crisis caused by a virus officially named as severe acute respiratory syndrome coronavirus 2 and well known with the acronym (SARS-CoV-2). This very contagious illness has severely impacted people and business all over the world and scientists are trying so far to discover all useful information about it, including its potential origin(s) and inter-host(s). This study is a part of this scientific inquiry and it aims to achieve two main objectives: (1) to identify precisely the origin(s) of a large set of genomes of SARS-COV-2 collected from different geographic locations in all over the world, and (2) to study the relation between these genomes and the regions of sampling. This research is performed through the combination of five powerful techniques of machine learning (Naïve Bayes, K-Nearest Neighbors, Artificial Neural Networks, Decision tree and Support Vector Machine) and a widely known tool of language modeling (N-grams). The experimental results have shown that the majority of techniques gave the same global results concerning the origin(s) and inter-host(s) of SARS-COV-2. These results demonstrated that this virus has multiple origins with different degrees. Also, they were used to study the relation that exists between the geographic locations from where the genomes of COVID-19 were collected and the origins of this virus.
Attitudes and concerns of health sciences students in Croatia regarding complete switch to e-learning during COVID-19 pandemic: a survey
Authors: Puljak Livia , Civljak Marta , Haramina Ana , Malisa Snjezana , Cavic Dalibor , Klinec Dinko , Aranza Diana , Mesaric Jasna , Skitarelic Natasa , Zoranic Sanja , Majstorovic Dijana , Neuberg Marijana , Miksic Stefica , Ivanisevic Kata 
Published: July 2020

Abstract
Background: Croatia has closed all educational institutions after 32 cases of SARS-CoV-2 infection were confirmed and switched to exclusive e-learning. Health sciences university students may have been particularly disrupted with this change due to lack of practical education. It is not known how health sciences students and schools have adjusted to exclusive e-learning. The aim of this study was to explore attitudes and concerns of health sciences students in Croatia regarding complete switch to e-learning during COVID-19 pandemic.Methods: Eligible participants were students from 9 institutions offering university-level health sciences education in Croatia enrolled in academic year 2019/2010, and participating in e-learning. Data were collected with questionnaire distributed via email during April/May 2020.Results: A total of 2520 students (aged 25.7±7.7 years) responded to the questionnaire (70.3% response rate). General satisfaction with exclusive e-learning was rated with average grade 3.7 out of 5. Compared with previous education, exclusive e-learning was rated with average grade 3.2 out of 5. Compared to classroom learning, equal or higher motivation to attend exclusive learning was reported by 64.4% of participants. With longer duration of exclusive e-learning, equal or higher motivation was reported by 65.5% of participants. Less than half of the students indicated they felt deprived or concerned due to the lack of practical lessons. Most participants indicated that in the future, they would prefer to combine classic classroom and e-learning (N=1403; 55.7%).Conclusions: Most health sciences students were satisfied with the exclusive e-learning, as well as their personal and institutional adjustment to it. Students’ feedback can help institutions to improve exclusive e-learning experience for students in time of pandemic.
Factors that Influence Professional Socialization in Nursing Students A Multigroup Analysis
Authors: Pai Hsiang Chu , Cheng Hui-Hua , Huang Yu-Ling 
Published: July 2020

Abstract
Background

Nursing professional socialization significantly influences the sustainable development of nursing students’ careers. Nevertheless, there is still a lack of research on the factors that influence nursing professional socialization in nursing education. This study aims to examine the factors that influence professional socialization in nursing students. The study adopts a multigroup approach for comparison between female and male subsamples.
Methods

This is a cross-sectional, quantitative study of a sample of 108 nursing students (80 females and 28 males). The Simulation Learning Effectiveness Scale, Caring Assessment Report Evaluation Q-sort, Self-Reflection and Insight Scale, and Holistic Nursing Competence Scale were used to collect the data on the independent variables. The Team Skills Scale, Nursing Image as a Profession questionnaire, and Nursing Professional Commitment Scale were used to assess the level of students’ nursing professional socialization, which is an outcome construct variable. A multigroup analysis with partial least squares structural equation modeling was used to analyze the data and to examine the professional socialization research model.
Results

The full model findings show that individual learning effectiveness had a significantly positive effect on nursing students’ caring behavior (ß = 0.47, p < .001) and on self-reflection and insight (ß = 0.32, p < 0.1). In addition, caring behavior (ß = 0.64, p < .001) and self-reflection and insight (ß = 0.29, p < .001) had a significantly positive effect on nursing competence. Finally, nursing competence also had a significantly positive effect on nursing professional socialization (ß = 0.61, p < .001). Overall, all independent variables were significant predictors of nursing professional socialization, explaining 36.7% of the variance in the integrated model of professional socialization. In addition, a permutation test revealed no differences in the two comparisons’ path coefficient estimates in the model (female vs. male).
Conclusion

The findings reveal that the result of an all-path coefficient parametric on the professional socialization model does not differ by gender. Therefore, for both female and male students, it is important to further strengthen nursing students’ self-learning effectiveness to promote their self-reflection and caring behavior. Increasing students’ nursing competence is a key factor in improving their professional socialization.
Predictive scoring models for persistent gram-negative bacteremia that reduce the need for follow-up blood cultures: a retrospective observational cohort study
Authors: Jung Jongtak , Song Kyoung-Ho , Jun Kang Il , Kang Chang Kyoung , Kim Nak-Hyun , Choe Pyoeng Gyun , Park Wan Beom , Bang Ji Hwan , Kim Eu Suk , Park Sang-Won , Kim Nam Joong , Oh Myoung-don , Kim Hong Bin 
Published: July 2020

Abstract
Background: Although the risk factors for positive follow-up blood cultures (FUBCs) in gram-negative bacteremia (GNB) have not been investigated extensively, FUBC has been routinely carried out in many acute care hospitals. We attempted to identify the risk factors and develop a predictive scoring model for positive FUBC in GNB cases.Methods: All adults with GNB in a tertiary care hospital were retrospectively identified during a 2-year period, and GNB cases were assigned to eradicable and non-eradicable groups based on whether removal of the source of infection was possible. We performed multivariate logistic analyses to identify risk factors for positive FUBC and built predictive scoring models accordingly. Results: Out of 1,473 GNB cases, FUBCs were carried out in 1,268 cases, and 122 produced positive results. In patient with eradicable source of infection, we assigned points according to the coefficients from the multivariate logistic regression analysis: Extended spectrum beta-lactamase producing microorganism (+1 point), Catheter-related bloodstream infection(+1), unfavorable treatment response (+1), and quick sequential organ failure assessment score of 2 points or more (+1), administration of effective antibiotics (-1), and adequate source control (-2). In non-eradicable source of infection, assigned points were end-stage renal disease on hemodialysis (+1), unfavorable treatment response (+1) and the administration of effective antibiotics (-2). The areas under the curves were 0.861 (95% confidence interval [95CI] 0.806-0.916) and 0.792 (95CI, 0.724-0.861), respectively. When we applied a cut-off of 0, the specificities and negative predictive values (NPVs) in the eradicable and non-eradicable sources of infection groups were 95.6/92.6% and 95.5/95.0%, respectively.Conclusions: FUBC is commonly carried out in GNB cases, but the rate of positive results is less than 10%. In our simple predictive scoring model, zero scores—which were easily achieved following the administration of effective antibiotics and/or adequate source control in both groups—had high NPVs. We expect that the model reported herein will reduce the necessity for FUBCs in GNB cases.
The Emerging Role of Neutrophil Extracellular Traps in Severe Acute Respiratory Syndrome Coronavirus 2 (COVID-19)
Authors: Arcanjo Angélica , Logullo Jorgete , Menezes Camilla Cristie Barreto , Giangiarulo Thais Chrispim de Souza Cravalho , Barroso Shana Priscila Coutinho , Todeschini Adriane , Freire-de-Lima Leonardo , Decoté Debora Ricardo , Freire-de-Lima Celio Geraldo , Silva Fátima Conceição , Savino Wilson , Morrot Alexandre 
Published: July 2020

Abstract
The novel coronavirus SARS-CoV2 causes COVID-19, a highly pathogenic viral infection threatening millions. The majority of those infected are asymptomatic or mildly symptomatic showing typical clinical signs of common cold. However approximately 20% of the patients can progress to acute respiratory distress syndrome (ARDS) and eventually death in about 5% of cases. Recently, angiotensin-converting enzyme 2 (ACE2) has been shown to be a functional receptor for virus entry into host target cells. The upregulation of ACE2 in patients with comorbidities may represent a propensity for increased viral load and spreading of infection to extrapulmonary tissues. This systemic infection is associated with higher neutrophil to lymphocyte ratio in infected tissues and high levels of pro-inflammatory cytokines leading to an extensive microthrombus formation with multiorgan failure. Herein we investigated whether SARS-CoV2 can stimulate extracellular neutrophils traps (NETs) in a process called NETosis. We demonstrated for the first time that SARS-CoV2 in fact is able to activate NETosis in human neutrophils. Our findings indicated that this process is associated with increased levels of intracellular Reactive Oxygen Species (ROS) in neutrophils. The ROS-NET pathway plays a role in thrombosis formation and our study suggest the importance of this target for therapy approaches against disease.
Bioremediation of Spent Engine Oil on Selected Contaminated Soils within Ilorin Metropolis
Authors: AJIBOYE Adeyinka Elizabeth , SULAYMAN Hikmat Omolara , AJAO Abdullahi Taiwo 
Published: July 2020

The research aimed to investigate the bioremediation of spent engine oil on selected contaminated soils within Ilorin metropolis. To achieve this, soil samples were collected from three (3) mechanic workshops along Taiwo axis within the metropolis. The soil samples were then subjected to bioremediation using the land-farming approach. The physicochemical parameters of the soil samples before and after bioremediation were analyzed using standard methods. Bacteria were isolated using standard procedures and identified using biochemical tests and molecular methods. Results for the physicochemical parameters of the soil samples before bioremediation include particle size (all sandy in nature); pH (6.00 ± 0.14 - 6.20 ± 0.14); Organic carbon (14.65 ± 3.20 - 17.54 ± 1.87), Organic matter (33.50 ± 0.85 - 43.45 ± 9.12) and heavy metals (ND - 11.74 ± 0.07). Values after bioremediation for pH, organic carbon, organic matter and heavy metals were 8.25 ± 0.07 - 8.90 ± 0.14, 13.07 ± 0.05 - 13.25 ± 0.84, 37.25 ± 1.06 - 44.80 ± 1.13, ND - 9.40 ± 0.04 respectively. Values for bacterial count before and after bioremediation of the soil samples were 8.00 1.41 - 67.50 ± 2.12 x 105 CFU/mL and 6.50 ± 2.12 - 164.00 ± 11.31 x 105 CFU/mL respectively. Bacterial isolates were identified as Pseudomonas sp., Enterobacter sp., Acinetobacter sp., and Bacillus sp. while the hydrocarbon-utilizing bacteria were identified as Thalassospira mesophila strain JCM 18969; Pseudomonas fluorescens F113; Siccibacter turicensis LMG 23730; Pseudomonas Zeshuii strain KACC 15471; Pseudomonas stutzeri strain CGMCC 1.1803 and Marinobacter hydrocarbonoclasticus strain ATCC 49840. In conclusion, the bacteria isolates effectively bioremediated the spent engine oil contaminated soils with a reduction of hydrocarbon pollutants.
Assessment of Water Quality Index and Irrigation Indices in Ese Odo Area of Ondo State, Southwestern Nigerian
Authors: Olumuyiwa Falowo Olusola , Olayemi Ojo Olajumoke 
Published: July 2020

An assessment of the ground water quality was carried out in Ese Odo local government area of Ondo State, southwestern Nigeria. The study was aimed at examining the various samples of ground water and the quality of the ground water as it relates to drinking and irrigation purposes. Forty-Five ground water samples were taken from boreholes and open wells and analyzed for physical, chemical and biological properties. The results were compared with World Health Organization standards. The usefulness of these parameters in predicting ground water quality characteristics were studied and water quality index was determined from these parameters. In assessing the water for irrigation uses, indices such as percent (%Na), sodium adsorption ratio (SAR), residual sodium carbonate (RSC), permeability index (PI), Kelly’s ratio (KR), magnesium ratio (MR), equivalent salinity concentration (ESC) and Wilcox plot were used. The result obtained shows that the water studied has a mean value of 2.8 NTU for turbidity, 7.3 for pH, 294 μS/cm for electrical conductivity, 52mg/L for total dissolved solids, temperature 28.3°C, total hardness 41 mg/L, chloride 38.3 mg/L, calcium 15.8 mg/L, 5.64 mg/L for magnesium, nitrate 1.47mg/L, sulphate 51.7 mg/L, bicarbonate 15mg/L. Zinc, iron, manganese have mean values less than 1mg/L. The results indicated all the physicochemical parameters are within the recommended levels set by World Health Organization (WHO). Although traces of heavy metal and mineral oil contaminations are observed some of the samples. All the samples are plotted on the “Excellent irrigation class” of Wilcox plot with good/excellent irrigation indices. Consequently, the groundwater in the study area is good and suitable for drinking and irrigation purposes.
3D numerical modelling and analysis of a magnetorheological elastomer (MRE)
Authors: Syam Thaer M. I. , Muthalif Asan G. A. , Salem Ayman M. H. , Hejazi Ahmed A. A. 
Published: July 2020

Magneto rheological elastomer (MRE) is a smart material consists of a polymer matrix embedded micro/nano-sized magnetic particles. Its mechanical properties are altered by external magnetic fields. In this article, a magnetic-mechanical coupled physics is done for MRE using COMSOL multi-physics finite element analysis (FEA) software for a particle level (micro-scale). Both linear and torsional transmissibility analysis are done on MRE under influence of magnetic fields. Simulation results indicate both linear and torsional stiffness increased with magnetic field. Under the initial influence of magnetic field, it is shown that an increase of 28.75 % and 20.12 % of the stiffness in linear and torsional modes, respectively. Transmissibility curve showed shift in the natural frequency due to increase in stiffness when exposed to a magnetic field. Vibration isolation was reached by achieving a minimum transmissibility factor.
Composition and Quality Standards of Functional Caramel
Authors: Reznichenko Irina , Renzyaeva Tamara , Renzyaev A. 
Published: July 2020

Introduction. Functional foods help to improve the diet, maintain health, and prolong active longevity. Therefore, food science constantly develops new formulations of functional products. Caramel can hardly be called healthy food as it possesses low nutritional and high energy value. Moreover, caramel contains easily digested sugars but no physiologically functional ingredients, e.g. vitamins, minerals, etc. In order to increase the nutritional value of caramel, we fortified the traditional formulation with ascorbic acid and Valetek-3 vitamin premix.
Study objets and methods. The research featured laboratory and pilot samples of caramel. The quality indicators of the finished product were determined according to the industry standards.
Results and discussion. The research provided advanced formulations and technology for the development of the new functional caramel fortified with ascorbic acid and a vitamin complex. A set of experiments resulted in a nomenclature of regulated quality indicators and functional properties. The changes in the quality of the caramel during storage made it possible to define the shelf-life of the product.
Conclusion. The research defined the optimal formulation for the new kind of functional caramel and determined its quality indicators. The present article introduces a list of quality standards for caramel fortified with vitamin C (ascorbic acid) and Vitalek-3 vitamin premix, as well as the indicators of its functional properties. The research provided the new functional food with the regulatory and technical documentation necessary for its mass production.
Instant Drinks with Amaranth Flour: Simulation of Mechatronic Systems of Production
Authors: Popov Anatoly , Plotnikov Konstantin , Ivanov Pavel , Donya Denis , Pachkin Sergei , Plotnikova Irina 
Published: July 2020

Introduction. The world market of instant drinks is a highly competitive environment. New mechatronic production systems can help food companies maintain their competitiveness: they determine process modes, analyze them, and choose the optimal parameters, thus increasing the efficiency of the whole food enterprise. Another problem is the low biological and nutrient value of the finished product. New biologically active instant drinks could solve the problem that occurs in conditions of unsocial hours and unbalanced diet. Products of plant origin contain a lot of useful substances. Amaranth flour increases the biological value of the final products. The research objective was to develop mechatronic systems that could be used to produce instant drinks fortified with amaranth flour at the granulation stage.
Study objects and methods. The present research featured a new line of production of instant granular drinks fortified with amaranth flour. The study focused on the granulation section. A drum vibro-granulator with controlled segregated flows was used to make a hardware design of the granulation process. The granulation process often demonstrates an unstable particle size distribution, which is associated with non-uniform mixing of the dry bulk components with the binder solution. A mechatronic module can solve this problem. However, it requires detailed information about the process conditions.
Results and discussion. The research determined the specific energy consumption on the operating and design parameters for the granulation process in the new drum vibro-granulator. The experiment made it possible to obtain the optimal process parameters and improve the quality of the finished product. The flow rate of the binder solution depended on the readings of the power consumed by the kneading body engine, which stabilized the system. The value of this parameter is so small that its direct regulation is technically impossible. The paper introduces a block diagram of a multi-circuit cascade system to control the quality of the mixture automatically. The authors installed a valve on the pipeline that feeds the binder fluid in the pressure tank. The valve made it possible to control the process with sufficient accuracy.
Conclusion. In the new mechatronic module of the drum vibro-granulator, the quality indicators of the resulting mix depend on the amount of power consumed by the kneading body engine and on the level of the binder solution in the pressure vessel.
Disulfide Bond-Responsive Nanotherapeutic Systems for the Effective Payload in Cancer Therapy
Authors: Shende Pravin , Deshpande Gauraja 
Published: July 2020

Background:
The progressive treatment of cancer using disulfide bond-based therapeutics offers improvement
in therapeutic potency of active, reduction in adverse events, prolongation of drug release pattern and
on-site action by interacting with neoplastic cell microenvironment.

Objective:
The objective of this article is to highlight the research carried out on disulfide bond-based drug delivery
systems as a potential candidate for cancer treatment.

Methods:
The article provides an overview of the importance of disulfide bonds in cancer treatment in terms of
their properties, mechanism of formation/fragmentation and applications. Properties of disulfide bonds, such as
pKa, entropy, and dihedral angle contribute to the structural stability of the bonds in a nanotherapeutic system,
while their formation and fragmentation are attributed to the presence of a high concentration of GSH in cancer
cells. The article further focuses on various drug delivery systems like dendrimers, liposomes, micelles, etc. involving
disulfide cross-linked polymers for the preparation of redox-responsive drug delivery systems.

Results:
The use of nanotechnology with disulfide bond creates an anticancer drug delivery system with higher
target specificity, improved bioavailability, and good therapeutic efficacy.

Conclusion:
In the near future, the combination of DSB with active, cellular material, stem cell and biological
fluid will be considered as a new thrust area for research in healthcare.