bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Tutsi family harbouring two new RHCE variant alleles and a new haplotype in the Rh blood group system
Authors: Deleers Marie , Thonier Vincent , Claes Vincent , Daelemans Caroline , Peyrard Thierry , El Kenz Hanane 
Published: March 2020

BackgroundRHCE*ceEK is a rare RH allele mostly encountered in people of African descent. This allele is defined by four single nucleotide substitutions: c.48G>C, c.712A>G, c.787A>G and c.800T>A. Until now, it has only been reported to segregate with either RHD*01N.01 or RHD*DAR1.00.Materials and MethodsBlood samples were drawn from a 32‐year‐old Tutsi pregnant woman during an antenatal visit in order to perform her type and screen. To further investigate the results found in the patient, a family study was conducted. Standard haemagglutination methods were used to investigate the subjects’ red blood cells and plasma. Molecular workup on RHD and RHCE genes was carried out by DNA microarray, real‐time PCR and DNA sequencing techniques.ResultsThe patient was phenotyped as group B, D+C−E−c+e+, Hr−. A complex mixture of anti‐E, anti‐c, anti‐Hr and anti‐hrS was detected in her plasma. She was found to carry a normal RHD gene, a conventional RHCE*ceEK allele and an alternative RHCE*ceEK allele (RHCE*ceEK without c.48G>C). The family study showed that the conventional RHCE*ceEK and the alternative RHCE*ceEK alleles were associated with a RHD*01 allele and a RHD*01N.01 allele, respectively. Molecular analysis performed in the proband’s mother showed a novel RHCE*ce variant allele on a RHCE*ceS‐like background (RHCE*ceS with c.609G>A).ConclusionsThis case study brought out new associations between RHD and RHCE alleles encoding the rare Hr− phenotype: the conventional RHCE*ceEK allele linked to the RHD*01 allele and an alternative RHCE*ceEK allele associated with the RHD*01N.01 allele. A novel RHCE*ce variant (RHCE*ceS with c.609G>A) was also reported.
Electronic charting of transfusion medicine consults: implementation, challenges and opportunities
Authors: Mohammad Mohammad K. , Wooten Melanie S. , Maier Cheryl L. , Hill Charles E. , Guarner Jeannette , Roback John D. , Winkler Anne M. , Sullivan Harold C. 
Published: March 2020

BackgroundThe Joint Commission lists improving staff communication (handoffs) as part of several National Safety Goals. In this study, we developed an electronic web‐based charting system for clinical pathology handoffs, which primarily consist of transfusion medicine calls, and evaluated the advantages over a paper‐based handwritten call log.Materials and MethodsA secure online web browser application using Research Electronic Data Capture (REDCap) was designed to document on‐call pathology resident consults. A year after implementation, an online survey was administered to our pathology residents in order to evaluate and compare the usability of the electronic application (e‐consults) to the previous handwritten call log, which was a notebook where trainees hand wrote different components of the consult.ResultsThe REDCap web‐based application includes discrete fields for patients’ information, requesting physician contact, type of consult, action items for follow‐up and faculty responses, as well as other information. These components have eventually progressed to be an online consult call catalog. With approximately 1079 consults per year, transfusion medicine‐related calls account for ~90% of the encounters, while clinical chemistry, microbiology and immunology calls constitute the remainder. The overall response rate of the survey was 96% (29 of 30 participants). Of the 16 respondents who experienced both call log systems, 100% responded that REDCap was an improvement over the handwritten call log (P < 0·0001).ConclusionE‐consult documentation entered into a web‐based application was a user‐friendly, secure clinical information access and effective handoff system as compared to a paper‐based handwritten call log.
A systematic review and meta‐analysis of predictors of human hepatitis E virus exposure in non‐endemic countries
Authors: Wilhelm Barbara , Waddell Lisa , Greig Judy , Young Ian 
Published: March 2020

AbstractThe reported incidence of clinical hepatitis E cases is rising in some non‐endemic countries, with concurrent concerns regarding potential hepatitis E virus (HEV) contamination of the blood supply. Therefore, the characterization of major potential sources of human HEV exposure is important to inform risk assessment and public health policy. A systematic review was conducted, including a comprehensive search in six electronic bibliographic databases, verified by hand‐searching reference lists of HEV reviews, and a grey literature search, of the broad research question ‘what is the evidence of the association between predictors of human HEV exposure, and HEV IgG seropositivity, in non‐endemic countries?’ Using forms designed a priori, captured studies were appraised at first‐level screening, second‐level characterization, and third‐level data extraction and risk of bias assessment. Meta‐analysis yielded summary estimates of association between potential predictors and odds of HEV seropositivity. Meta‐analysis and meta‐regression of the odds of HEV seroprevalence in specific groups characterized potential sources of HEV exposure. From 4,163 captured citations, 245 relevant studies underwent data extraction, investigating HEV seroprevalence or predictors in both healthy subjects and targeted patient groups. Across these groups, increasing age was a predictor of HEV IgG seropositivity. Both human immunodeficiency virus patients and haemodialysis patients had significantly increased odds of HEV seropositivity relative to the general population. Working with pigs, in forestry, or in hospitals, was significantly associated with increased odds of HEV seropositivity, as were consumption of meat, pork or game meat, or hunting. Chronological time was not associated with HEV seropositivity within our data sets. Further study of the distribution of potential dietary or behavioural predictors between high and lower prevalence areas within non‐endemic countries could improve our understanding of the relative importance of specific HEV transmission pathways.
Study on the Fuel Flexibility of a Microgas Turbine Combustor Burning Different Mixtures of H2, CH4, and CO2
Authors: Di Nardo Antonio , Bo Alessandro , Calchetti Giorgio , Giacomazzi Eugenio , Messina Giuseppe 
Published: March 2020

Abstract
The aim of this work is to analyze the behavior of the fuel flexible Ansaldo ARI100 T2 microgas turbine (MGT) combustor operated with mixtures having different H2, CH4, and CO2 concentrations. This combustor is going to be installed on an in-house modified Turbec T100 P MGT, which is originally equipped with a methane fired combustor. In a previous study, the combustor was simulated with a H2 enriched syngas, whose Wobbe index was within the limits imposed by the syngas supply system of an Ansaldo test bench. In this study, this constraint has been removed to gain a deeper understanding on how the fuel mixture properties (composition, heating value, and laminar flame speed) affect combustor performance. To this end, a series of Reynolds-averaged Navier–Stokes (RANS) computational fluid dynamics (CFD) simulations have been carried out on the full-scale 3D geometry of the combustion chamber, at full and partial load (50%), evaluating for each case combustion efficiency as well as NOx and CO emissions.
Measure what we want: a taxonomy of short generic person-reported outcome and experience measures (PROMs and PREMs)
Authors: Benson Tim 
Published: March 2020

IntroductionHealth and care systems are complex and multifaceted, but most person-reported outcome and experience measures (PROMs and PREMs) address just one aspect. Multiple aspects need measuring to understand how what we do impacts patients, staff and services, and how these are affected by external factors. This needs survey tools that measure what people want, are valid, sensitive, quick and easy to use, and suitable for people with multiple conditions.MethodsWe have developed a coherent family of short generic PROMs and PREMs that can be used in combination in a pick-and-mix way. Each measure has evolved iteratively over several years, based on literature review, user inputs and field testing. Each has has a common format with four items with four response options and is designed for digital data collection with standardised analytics and data visualisation tools. We focused on brevity and low reading age.ResultsThe results are presented in tabular format and as a taxonomy. The taxonomy is categorised by respondent type (patient or staff) and measure type. PROMs have subdomains: quality of life, individual care and community; PREMs have subdomains: service provided, provider culture and innovation. We show 22 patient-reported measures and 17 staff-reported measures. Previously published measures have been validated. Others are described for the first time.Discussion and conclusionsThis family of measures is broad in scope but is not claimed to be comprehensive. Measures share a common look and feel, which enables common methods of data collection, reporting and data visualisation. They are used in service evaluation, quality improvement and as key performance indicators. The taxonomy helps to organise the whole, explain what each measure does and identify gaps and overlaps.
Peer Prediction with Heterogeneous Users
Authors: Agarwal Arpit , Mandal Debmalya , Parkes David C. , Shah Nisarg 
Published: March 2020

Peer prediction mechanisms incentivize agents to truthfully report their signals, in the absence of a verification mechanism, by comparing their reports with those of their peers. Prior work in this area is essentially restricted to the case of homogeneous agents, whose signal distributions are identical. This is limiting in many domains, where we would expect agents to differ in taste, judgment, and reliability. Although the Correlated Agreement (CA) mechanism [Shnayder et al. 2016a] can be extended to handle heterogeneous agents, there is a new challenge of efficiently estimating agent signal types. We solve this problem by clustering agents based on their reporting behavior, proposing a mechanism that works with clusters of agents, and designing algorithms that learn such a clustering. In this way, we also connect peer prediction with the Dawid and Skene [1979] literature on latent types. We retain the robustness against coordinated misreports of the CA mechanism, achieving an approximate incentive guarantee of
ε
-informed truthfulness. We show on real data that this incentive approximation is reasonable in practice, even with a small number of clusters.
Identification of Non–Small Cell Lung Cancer Sensitive to Systemic Cancer Therapies Using Radiomics
Authors: Dercle Laurent , Fronheiser Matthew , Lu Lin , Du Shuyan , Hayes Wendy , Leung David K. , Roy Amit , Wilkerson Julia , Guo Pingzhen , Fojo Antonio T. , Schwartz Lawrence H. , Zhao Binsheng 
Published: March 2020

Abstract

Purpose:
Using standard-of-care CT images obtained from patients with a diagnosis of non–small cell lung cancer (NSCLC), we defined radiomics signatures predicting the sensitivity of tumors to nivolumab, docetaxel, and gefitinib.

Experimental Design:
Data were collected prospectively and analyzed retrospectively across multicenter clinical trials [nivolumab, n = 92, CheckMate017 (NCT01642004), CheckMate063 (NCT01721759); docetaxel, n = 50, CheckMate017; gefitinib, n = 46, (NCT00588445)]. Patients were randomized to training or validation cohorts using either a 4:1 ratio (nivolumab: 72T:20V) or a 2:1 ratio (docetaxel: 32T:18V; gefitinib: 31T:15V) to ensure an adequate sample size in the validation set. Radiomics signatures were derived from quantitative analysis of early tumor changes from baseline to first on-treatment assessment. For each patient, 1,160 radiomics features were extracted from the largest measurable lung lesion. Tumors were classified as treatment sensitive or insensitive; reference standard was median progression-free survival (NCT01642004, NCT01721759) or surgery (NCT00588445). Machine learning was implemented to select up to four features to develop a radiomics signature in the training datasets and applied to each patient in the validation datasets to classify treatment sensitivity.

Results:
The radiomics signatures predicted treatment sensitivity in the validation dataset of each study group with AUC (95 confidence interval): nivolumab, 0.77 (0.55–1.00); docetaxel, 0.67 (0.37–0.96); and gefitinib, 0.82 (0.53–0.97). Using serial radiographic measurements, the magnitude of exponential increase in signature features deciphering tumor volume, invasion of tumor boundaries, or tumor spatial heterogeneity was associated with shorter overall survival.

Conclusions:
Radiomics signatures predicted tumor sensitivity to treatment in patients with NSCLC, offering an approach that could enhance clinical decision-making to continue systemic therapies and forecast overall survival.
Muslim Organisations’ Response to Stigmatisation in the Media
Authors: Kassaye Aida , van Heelsum Anja 
Published: March 2020

Abstract
In the heated media debate on Muslims and Islam, the role of community representatives is understudied. This article will first use original research see to what extent Muslims get the chance to speak out in newspapers in Western Europe, and then demonstrate through findings from interviews how representatives of Muslim organisations operate in the media. We build on Kerstin Rosenow-Williams’s perspectives in combining two features, namely 1) the internal and external role of representatives of Muslim organisations, and 2) the active-passive dimension of responses to prejudice and stigmatisation as suggested in social psychology, and will distinguish three patterns: protest, adaptation and decoupling. Throughout the article, we zoom in on the remarkable dissimilarity between the UK and Germany. The British case shows a larger Muslim presence in the newspapers and the tendency of Muslim representatives to use a protest strategy, while the German case shows a lack of Muslim actors in the newspapers and a tendency of Muslim representatives to use an adaptation strategy.
VolKilau: Volcano Rapid Response Balloon Campaign during the 2018 Kilauea Eruption
Authors: Vernier J.-P. , Kalnajs L. , Diaz J. A. , Reese T. , Corrales E. , Alan A. , Vernier H. , Holland L. , Patel A. , Rastogi N. , Wienhold F. , Carn S. , Krotkov N. , Murray J. 
Published: March 2020

AbstractAfter nearly 35 years of stable activity, the Kilauea volcanic system in Hawaii went through sudden changes in May 2018 with the emergence of 20 volcanic fissures along the Lower Eastern Rift Zone (LERZ), destroying 700 homes in Leilani Estates and forcing more than 2,000 people to evacuate. Elevated volcanic emissions lasted for several months between May and September 2018, leading to low visibility and poor air quality in Hawaii and across the western Pacific. The NASA-funded VolKilau mission was rapidly mounted and conducted between 11 and 18 June 2018 to (i) profile volcanic emissions with SO2 and aerosol measurements, (ii) validate satellite observations, and (iii) increase readiness for the next large volcanic eruption. Through a series of balloon-borne measurements with tethered and free-released launches, we measured SO2 concentration, aerosol concentration, and optical properties 60–80 km downwind from the volcanic fissures using gas sensors, optical particle counters, backscatter sondes, and an aerosol impactor. While most of the measurements made during the Kilauea eruption were ground based, the VolKilau mission represented a unique opportunity to characterize plume properties, constrain emission profiles, study early chemistry involving the conversion of SO2 into sulfuric acid, and understand the influence of water clouds in the removal of SO2. This unprecedented combination of measurements has significantly improved our team’s ability to assess the atmospheric and human impacts of a major event such as this.
Reforming Responses to the Challenges of Judicial Incapacity
Authors: Lynch Andrew , Blackham Alysia 
Published: March 2020

AbstractJudicial incapacity, while under-researched, presents unique challenges for supporting and responding to issues of judicial performance. In this article, we argue for a reconceptualisation of this topic based on contemporary theories of socially-constructed disability and principles of anti-discrimination law. While assisting and supporting judicial officers who are attempting to work with a disability or ongoing health issue will always be complex, this reconceptualisation offers heads of jurisdiction, conduct commissions and parliamentarians, who retain the ultimate sanction of removal, the opportunity to craft a surer guide for handling cases of incapacity. This will not only better serve the individual concerned, affording them greater agency and dignity than has traditionally been the case, but also protect the principle of judicial independence.
Ablation of the great saphenous vein with F-care versus Closurefast endovenous radiofrequency therapy: Double-blinded prospective study
Authors: Bitargil Macit , Kılıç Helin E 
Published: March 2020

Objectives F-care (endovenous radiofrequency, F Care Systems, Antwerp, Belgium) is a relatively new radiofrequency ablation technique for the treatment of venous insufficiency. There is a lack of published data about F-care in literature. This study aimed to prospectively compare the F-care method with conventional endovenous radiofrequency ablation Closurefast method for the management of incompetent great saphenous veins. Methods Between June 2015 and December 2018, 114 patients with incompetent varicose veins were treated either with the F-care or Closurefast. The pre-, intra-, postprocedural, and follow-up data of the patients were collected and prospectively compared. Results The average ablated vein length was 23.1 ± 4 cm in the F-care group and 26.6 ± 4 cm in the Closurefast group ( P =  0.01). The average procedure time was 17.4 ± 4 min (range: 10–30 min) in the F-care group, and 17.1 ± 3 min (range: 11–27 min) in the Closurefast group ( P =  0.77). The one-month total occlusion rates in the F-care and Closurefast groups were 96.2% and 98.1%, respectively ( P =  0.5). The one-year full occlusion rates in the F-care and Closurefast groups were 71.7% and 90.6%, respectively ( P =  0.013). In both the F-care and Closurefast groups, the venous clinical severity scores declined significantly with no difference between groups. There was no significant difference between adverse events following F-care treatment compared with Closurefast treatment ( P ≤  0.05). Conclusions The F-care system was as safe and fast, but the one-year closure rate was significantly lower when compared to the other method. There was no significant difference between the adverse effects of both approaches. Further large-scale, multi-center prospective studies with long-term outcomes are required to identify the effectiveness of F-care treatment modality for patients with saphenous vein insufficiency.
Delirium in Meningitis and Encephalitis: Emergence and Prediction in a 6-Year Cohort
Authors: Dittrich Tolga , Marsch Stephan , Rüegg Stephan , De Marchis Gian Marco , Tschudin-Sutter Sarah , Sutter Raoul 
Published: March 2020

Background/Objective: Data regarding delirium in patients presenting with infections of the central nervous system, such as meningitis and/or encephalitis (ME), are scarce. We aimed to determine the frequency and early predictors of delirium in the acute phase of ME. Methods: We assessed clinical, radiologic, and laboratory data of patients with ME at a Swiss academic medical center from 2011 to 2017. The highest Intensive Care Delirium Screening Checklist (ICDSC) score was assessed within 24 hours around lumbar puncture. Multivariable logistic regression was performed to identify predictors of delirium (ICDSC ≥4). Results: Among 330 patients with ME, infectious pathogens were identified in 41%. An ICDSC >1 was found in 28% with and 19% without identified infectious pathogens. Delirium was diagnosed in 18% with and 14% without infectious pathogens and significantly associated with prolonged in-hospital treatment and mechanical ventilation, more frequent administration of neuroleptics and anesthetics (in 96% with delirium vs 35% without), complications, and less recovery to premorbid functional baseline. Low serum albumin at presentation was the only independent predictor of delirium (area under the receiver–operating curve [AUROC] = 0.792) in patients with pathogens. In patients with infections, the AUROC was smallest for encephalitis (AUROC = 0.641) and larger for patients with meningeal infections (meningitis AUROC = 0.807; meningoencephalitis AUROC = 0.896). Conclusions: Delirium in the context of ME is seen in almost every fifth patient and linked to prolonged treatment, complications, and incomplete recovery. Among clinical, radiologic, and laboratory parameters, the good calibration and discrimination of low albumin serum concentrations for the prediction of delirium in patients with ME seem promising, especially if meninges are affected.
Estimating the glomerular filtration rate in pregnancy: The evaluation of the Nanra and CKD-EPI serum creatinine-based equations
Authors: Gao Michael , Vilayur Eswari , Ferreira David , Nanra Ranjit , Hawkins Joan 
Published: March 2020

Aim To compare the performance of the Nanra and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimating glomerular filtration rate in pregnancy against the 24 h urine creatinine clearance. Methods Pregnant women had 24 h urine collections with simultaneous serum creatinine levels. Measured 24 h urine creatinine clearance was compared to two equations: Nanra and CKD-EPI. Level of concordance was measured, with an a priori bias acceptance of ±15 ml/min/1.73 m2. Results A total of 53 synchronous urine and serum creatinine samples were analysed. The Nanra equation had a bias of −13.4 ml/min/1.73 m2 while the CKD-EPI equation had bias of 14.2 ml/min/1.73 m2. Both equations showed a high degree of proportional error and had poor agreement with 24 h urine creatinine clearance. Conclusions None of the equations were shown to reliably measure the estimated glomerular filtration rate in pregnant women. A valid serum creatinine-based estimated glomerular filtration rate equation in pregnancy is yet to be established.
Clinical Outcomes after Arthroscopic Treatment of Synovial Chondromatosis in the Hip
Authors: Zhang Xin , Gao Guanying , Wang Jianquan , Xu Yan 
Published: March 2020

Purpose Evaluate the clinical outcomes after arthroscopic treatment of synovial chondromatosis (SC) of the hip. Materials and Methods We evaluated patients who underwent arthroscopic management for SC of the hip from November 2008 to March 2017. Radiographic evaluation was made before and after surgery. The modified Harris Hip Score (mHHS), Hip Disability and Osteoarthritis Outcome Score (HOOS), visual analogue scale (VAS) score, and patient self-reported satisfaction were collected and analyzed before and after surgery. Complications and recurrence that occurred after surgery were recorded. Results Forty-one patients (27 men and 14 women) were the study cohort. The mHHS improved from 67.0 to 83.7, HOOS-Symptoms improved from 78.8 to 93.3, HOOS-Pain improved from 80.9 to 93.6, HOOS-Activity Limitations–Daily Living improved from 84.5 to 95.1, HOOS-Sport improved from 50.3 to 80.6, and HOOS-Quality of Life improved from 62.2 to 86.7. VAS scores decreased from 3.9 to 1.1. All results demonstrated significant improvement ( P < 0.05). Thirty-three (80.5%) patients thought the outcome of surgery was “excellent,” 7 (17.0%) thought it was “good,” 1 (2.4%) thought it was “fair,” and no one thought it was “poor”. Two patients underwent revision surgery. Conclusion Hip arthroscopy for SC treatment of the hip showed good clinical results, good satisfaction from patients, and low recurrent prevalence.