bluuebunny/crossref_metadata_2025_split huggingface dataset:
miR‐3607, a biomarker of hepatocellular carcinoma invasion and aggressiveness: Its relationship with epithelial‐mesenchymal transition process
Authors: Hu Wen‐Yu , Wei Hai‐Yan , Liu Lu‐Yun , Li Ke‐Ming , Wang Ren‐Ben , Xu Xiao‐Qing , Feng Rui 
Published: April 2020

AbstractmicroRNA‐3607 (miR‐3607) has been identified as an important biomarker, and its aberrant expression exerts a significant role in tumorigenesis. However, the biological function of miR‐3607 in hepatocellular carcinoma (HCC) needs to be deciphered comprehensively. Clinical samples of HCC patients, as well as normal cases, were derived from The Cancer Genome Atlas database. Quantitative reverse transcription polymerase chain reaction (qRT‐PCR) and Western blotting analyses were utilized to detect the expression levels of indicated genes. Cell counting kit‐8 (CCK‐8), colony formation, and transwell assays were performed to assess the effect of miR‐3607 in HCC cell viability, migration, and invasion. Bioinformatics analysis and luciferase reporter gene assay was applied to screen the target genes of miR‐3607 and verified the association between miR‐3607 and its potential target gene. Our study showed that miR‐3607 expression was decreased in HCC tissues and cell lines, and its downregulation was linked with poor outcomes of HCC patients. miR‐3607 was noted to inhibit HCC cell growth, colony formation, migration, and invasion. Besides, minichromosome maintenance (MCM5) was a possible target gene of miR‐3607 in HCC. Overexpression of MCM5 was observed in HCC and induced unfavorable prognosis. MCM5 expression had a negative correlation with miR‐3607. MCM5 can abolish the suppressive impacts of miR‐3607 on HCC cell malignant behaviors and the epithelial‐mesenchymal transition (EMT) process. To sum up, our results unveiled that miR‐3607 could inhibit HCC cell growth, migration, and invasion by regulating MCM5 and mediating EMT process, suggesting a new probable biomarker for further treatment of HCC.
Serum levels of C1q/TNF‐related protein‐3 in inflammatory bowel disease patients and its inverse association with inflammatory cytokines and insulin resistance
Authors: Mohamadinarab Maryam , Ahmadi Reza , Gholamrezayi Afsane , Rahvar Farzaneh , Naghdalipour Mehri , Setayesh Leila , Moradi Nariman , Fadaei Reza , Chamani Elham , Tavakoli Tahmine , Esteghamati Abdoulreza 
Published: April 2020

AbstractUlcerative colitis (UC) and Crohn's disease (CD) are two major forms of inflammatory bowel disease (IBD), which is an inflammatory disease. Studies have shown that adipose tissue and inflammation play important roles in the pathogenesis of IBD. C1q/TNF‐related protein‐3 (CTRP3) is a newly discovered adipokine playing a substantial role during inflammatory process, and for the first time in the present study, serum levels of this adipokine were measured in the UC and CD patients. This case–control study included 70 control, 50 UC, and 50 CD patients who were diagnosed by standard criteria. Serum levels of adiponectin, IL‐6, TNF‐α, TGF‐β, and CTRP3 were evaluated using ELISA kits. Serum levels of IL‐6, TNF‐α, and TGF‐β elevated in the UC and CD patients compared with the controls while adiponectin and CTRP3 diminished in the patient's groups compared with the control. Furthermore, decrease in CTRP3 serum levels was associated with the risk of UC and CD diseases. Moreover, CTRP3 indicated negative correlation with BMI, FBS, insulin, homeostasis model assessment of insulin resistance, IL‐6, TNF‐α, and TGF‐β and also a positive correlation with adiponectin in both the UC and CD patients. For the first time, the present study demonstrated lower levels of CTRP3 in the UC and CD patients. Decreased serum levels of CTRP3 and its inverse relationship with inflammatory cytokines and TGF‐β levels suggested a possible role for CTRP3 in the pathogenesis of UC and CD diseases.
A review on synthesis of kaolin‐based zeolite and the effect of impurities
Authors: Hartati  , Prasetyoko Didik , Santoso Mardi , Qoniah Imroatul , Leaw Wai L. , Firda Putri B. D. , Nur Hadi 
Published: April 2020

AbstractZeolite is extensively synthesized for the application in a large variety of catalysis processes such as ion exchange, hydrocarbon cracking, and organic synthesis. In order to satisfy the serious terms of sustainability that denotes to the reduction of costs and chemical waste, kaolinite‐based zeolites were produced from cheap natural resources as against to the conventional process that employs pure sodium silicate and sodium aluminate. This review paper is to highlight the current trends in the synthesis of zeolite. Prior to previous reviews, great concern is focused on the impurities effect on the catalytic performance of kaolinite‐based zeolites. This study reveals that the impact of impurities in a catalytic reaction was in fact, underestimated or neglected. For instance, it was found that Fe ion concentration as small as 60 ppm gives significant catalytic output. Hence, a new practice to report the concentration of impurities in the research publication is suggested. This undoubtedly will generate a better interpretation of the catalytic activity from the zeolite framework.
Factor structure of the critical consciousness scale in juvenile legal system‐involved boys and girls
Authors: Singh Sukhmani , Javdani Shabnam , Berezin McKenzie N. , Sichel Corianna E. 
Published: April 2020

AbstractThe Critical Consciousness Scale (CCS) is a recently developed and validated measure for use with low‐income, diverse adolescents. However, research on the psychometric properties of this scale with juvenile legal system‐involved youth is lacking. This study examines the psychometric properties of the critical reflection subscales of the CCS in a cross‐sectional sample of 206 youth (48% girls) involved in the juvenile legal system to investigate (a) the factor structure of the critical reflection subscales of the CCS compared to existing adolescent samples, and (b) the extent to which critical reflection demonstrates measurement equivalence between boys and girls. Findings indicate (a) congruence with the previous literature on critical reflection but for system‐involved girls, and (b) a difference in the structural relationships between perceived inequality and egalitarianism by gender. This study contributes to the nascent, psychometric literature on measures of critical consciousness in an underrepresented and unique adolescent population.
Preparation, characterization, and application of nano‐FeOx/Al2O3/cordierite monolithic catalysts for heterogeneous dark Fenton reaction
Authors: Martinez Alejandra A , Fixman Esther M , Cánepa Analía L , Barbero Bibiana P 
Published: April 2020

AbstractBACKGROUNDAdvanced oxidation processes are an interesting alternative for wastewater treatment. The classic Fenton process, involving ferrous ions and hydrogen peroxide, requires strict pH adjustment and further iron removal. To overcome these difficulties, heterogeneous reaction with solid catalysts has been proposed. Until now, the solid catalysts have been employed as powders in agitated batch reactors. In this work, the application of structured catalysts for processes in flow is proposed. Nano‐FeOx/Al2O3/cordierite monolithic catalysts were prepared making firstly an alumina coating, and then impregnation with aqueous solution of iron nitrate at various concentrations. The synthesized catalysts were characterized using various techniques and then they were studied for the dark Fenton reaction.RESULTSThe coating adherence in the structured catalysts was better than 93%. Also, high homogeneity of the coating was confirmed. From results of physicochemical characterization, it was deduced that the active phase would consist of oligonuclear (FeO)n nanoclusters highly dispersed on the surface of the alumina support. The catalytic activity was evaluated in phenol peroxidation in aqueous phase (without light, pH 3, 30 °C), as a model reaction. The monolithic catalysts were active and chemically stable. The most active catalyst (phenol conversion > 90% at 80 min of reaction) was reused 12 times.CONCLUSIONSThe monolithic catalysts show a high potential for application in heterogeneous dark Fenton‐type reactions. Then, wastewater treatment by means of advanced oxidation processes could be carried out in continuous mode without further operation to separate the catalyst. © 2020 Society of Chemical Industry
Biventricular Reference Values by Body Surface Area, Age, and Gender in a Large Cohort of Well‐Treated Thalassemia Major Patients Without Heart Damage Using a Multiparametric CMR Approach
Authors: Meloni Antonella , Righi Riccardo , Missere Massimiliano , Renne Stefania , Schicchi Nicolò , Gamberini Maria Rita , Cuccia Liana , Lisi Roberto , Spasiano Anna , Roberti Maria Grazia , Zuccarelli Angelo , Ait‐Ali Lamia , Festa Pierluigi , Aquaro Giovanni Donato , Mangione Maurizio , Barra Valerio , Positano Vincenzo , Pepe Alessia 
Published: April 2020

BackgroundCardiac MRI plays a critical role in the management of thalassemic patients. No accurate biventricular reference values are available.PurposeTo establish the ranges for normal left ventricular (LV) and right ventricular (RV) volumes and ejection fraction (EF) and LV mass normalized to body surface area (BSA), age, and gender in a large cohort of well‐treated beta‐thalassemia major (β‐TM) patients without heart damage using a multiparametric MRI.Study TypeRetrospective/cohort study.PopulationIn all, 251 β‐TM patients with no known risk factors or cardiac disease, normal electrocardiogram, no macroscopic myocardial fibrosis, and all cardiac segments with T2* ≥20 msec, and 246 healthy subjects.Field Strength/Sequence1.5T/cine steady‐state free precession (SSFP), gradient‐echo T2*, late gadolinium enhancement (LGE) images.AssessmentBiventricular end‐diastolic volume, end‐systolic volume, stroke volume, and LV mass were normalized to BSA (EDVI, ESVI, SVI).Statistical TestsComparisons between the two groups was performed with two‐samples t‐test or Wilcoxon's signed rank test. For more than two groups, one‐way analysis of variance (ANOVA) or a Kruskal–Wallis test were applied.ResultsCompared to controls, males with β‐TM showed significantlt higher LVEDVI in all the age groups, while for the other volumes the difference was significant only within one or more age groups. In females the volumes were comparable between β‐TM patients and healthy subjects in all the age groups. In the male β‐TM population we found a significant effect of age on LVEDVI (P = 0.017), LVESVI (P = 0.001), RVESVI (P = 0.029), and RVEF (P = 0.031), while for females none of the biventricular parameters were significantly different among the age groups (LVEDVI: P = 0.614; LVESVI: P = 0.449; LVSVI: P = 0.186; LV mass index: P = 0.071; LVEF: P = 0.059; RVEDVI: P = 0.374; RVESVI: P = 0.180; RVSVI: P = 0.206; RVEF: P = 0.057). In β‐TM patients all biventricular volume indexes as well as the LV mass index were significantly larger in males than in females (P < 0.0001 in all cases). The LV and the RV EF were comparable between the sexes (P = 0.568 and P = 0.268, respectively).Data ConclusionAppropriate “normal” reference ranges normalized to BSA, sex, and age are recommended to avoid misdiagnosis of cardiomyopathy in β‐TM patients.Level of Evidence4Technical Efficacy Stage2
Assessment of the quality of systematic reviews on COVID‐19: A comparative study of previous coronavirus outbreaks
Authors: Yu Yang , Shi Qianling , Zheng Peng , Gao Lei , Li Haiyuan , Tao Pengxian , Gu Baohong , Wang Dengfeng , Chen Hao 
Published: April 2020

AbstractSeveral systematic reviews (SRs) have been conducted on the COVID‐19 outbreak, which together with the SRs on previous coronavirus outbreaks, form important sources of evidence for clinical decision and policy making. Here, we investigated the methodological quality of SRs on COVID‐19, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome (MERS). Online searches were performed to obtain SRs on COVID‐19, SARS, and MERS. The methodological quality of the included SRs was assessed using the AMSTAR‐2 tool. Descriptive statistics were used to present the data. In total, of 49 SRs that were finally included in our study, 17, 16, and 16 SRs were specifically on COVID‐19, MERS, and SARS, respectively. The growth rate of SRs on COVID‐19 was the highest (4.54/month) presently. Of the included SRs, 6, 12, and 31 SRs were of moderate, low, and critically low quality, respectively. SRs on SARS showed the optimum quality among the SRs on the three diseases. Subgroup analyses showed that the SR topic (P < .001), the involvement of a methodologist (P < .001), and funding support (P = .046) were significantly associated with the methodological quality of the SR. According to the adherence scores, adherence to AMSTAR‐2 items sequentially decreased in SRs on SARS, MERS, and COVID‐19. The methodological quality of most SRs on coronavirus outbreaks is unsatisfactory, and those on COVID‐19 have higher risks of poor quality, despite the rapid actions taken to conduct SRs. The quality of SRs should be improved in the future. Readers must exercise caution in accepting and using the results of these SRs.
Optimized buffer insertion for efficient interconnects designs
Authors: Khursheed Afreen , Khare Kavita 
Published: April 2020

AbstractThis typescript focuses on unraveling the functional performance deterioration issues related to conventional Cu on‐chip nanointerconnecting wires; mainly occurred due to the shrinking of device dimensions. Buffer insertion methodology proves to be an effective approach for designing high‐speed interconnect network but at the cost of power consumption. Moreover, ramification of too many buffers as repeaters leads to area overhead. Hence an optimized number must be judicially decided. Proposed circuits for buffers are modeled using variable diameter and multi Vt design techniques to balance delay as well as average power consumption. Interconnects designed with conventional Cu interconnect technology are compared with state of art CNT technology at different lengths. Proposed and Existing Buffer circuit architectures are modeled with both CNT and MOS technology to carry out the comparative simulation analysis using varied combination of CNTFET buffer‐CNT interconnect and CMOSFET buffer‐Cu interconnect. Benchmarking with conventional buffer circuits, simulated results illustrates that ProposedBuffer1 saves dynamic power by 89.96%, leakage power by 89%, and offers delay mitigation by 77.5%. ProposedBuffer2 brings about dynamic power saving of 99.94%, leakage power saving of 97.53%, but causes delay penalty. All the HSPICE simulations are carried out using Stanford SPICE model for CNT and BSIM4 PTM for MOS at 32 nm.
Study on the correlation between soil microbial diversity and ambient environmental factors influencing the safflower distribution in Xinjiang
Authors: Liu Yang , Zhang Xia , Yang Mei Ling , Wang Shao Ming 
Published: April 2020

AbstractThe effects of soil microbial properties and physiographical factors on safflower distributions in the main safflower plantations of Xinjiang province in China were studied. This study may help determine the basis of the environmental factors for evaluating the geoherbalism of this medicinal plant. The soil microbial biodiversity in the bulk soil and rhizosphere of safflower at different growth stages and from different sampling plots were characterized by analyzing the environmental DNAs in the samples. With general primers targeting the 16S ribosomal DNA for bacteria and the internal transcribed spacer 1 gene for fungi, the study was performed using marker gene amplification coupled with Illumina HiSeq high‐throughput sequencing technologies. Correlation analysis and a distance‐based redundancy analysis were performed to determine the dominant factors affecting the distribution of the microorganism in safflower soils. A total of 16517 bacterial operational taxonomic units (OTUs) were obtained from all the 108 soil samples of nine safflower sampling plots. At the phylum level, 48 phyla have been identified with Actinobacteria (32.9%) and proteobacteria (28.7%) being predominant. For fungi, 8746 OTUs were obtained, which belonged to seven phyla with Ascomycota overwhelmingly superior in relative abundance. A significant positive correlation was found between soil microbe quantity and ASL (above sea level). Safflower was sensitive to changes in elevation, growing more abundantly in the mountainous regions at heights of around 1,200 m above sea level. It is concluded that the dominant factors affecting the distribution of microorganisms in safflower soils were soil moisture, available N, and ASL.
Efflux pump inhibitory activity of biologically synthesized silver nanoparticles against multidrug‐resistant Acinetobacter baumannii clinical isolates
Authors: Behdad Reyhaneh , Pargol Minoo , Mirzaie Amir , Karizi Shohreh Zare , Noorbazargan Hassan , Akbarzadeh Iman 
Published: April 2020

AbstractThis study was carried out to investigate the possible efflux pump inhibitory activity of biologically synthesized silver nanoparticles (AgNPs) against multidrug‐resistant (MDR) Acinetobacter baumannii isolates. In this study, the physicochemical characteristics of synthesized AgNPs were investigated using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X‐ray diffraction (XRD), and Fourier transform infrared spectrophotometer (FTIR) methods. Subsequently, MDR A. baumannii isolates were recovered from clinical samples and the phenotypic cartwheel efflux assay and polymerase chain reaction (PCR) were used to elucidate the possible presence of efflux pump in MDR strains. After treatment of MDR strains with sub‐minimum inhibitory concentration (MIC) concentration of AgNPs, the expression level of efflux pump genes was evaluated using a quantitative real‐time PCR technique. The synthesized AgNPs had a spherical nanostructure, with mean size 38.89 nm, according to SEM and TEM data. XRD and FTIR results confirmed the synthesis of AgNPs. The results of PCR revealed that among 50 strains, 12 A. baumannii strains had efflux pump genes and the expression level of AdeA, AdeC, AdeS, AdeR, AdeI, AdeJ, and AdeK efflux pump genes was downregulated significantly after the treatment with AgNPs. In addition, the inhibitory effect of AgNPs on efflux pumps can be detected when the MIC of ethidium bromide (EtBr) with AgNPs is lower than that of EtBr alone. According to the results, the biologically synthesized AgNPs exhibit efflux pumps inhibitory activity, which may be one of the possible mechanisms of their antibacterial activity against MDR A. baumannii strains.
Derivation of nutritional threshold values from cumulative concentration distributions
Authors: Göttlein Axel 
Published: April 2020

AbstractFor many tree species nutritional threshold values are not available. Because the derivation of such values by fertilization experiments would be very time consuming and cost intensive a relatively easy method is proposed. By interpreting cumulative concentration distributions the thresholds for the range of normal nutrition as well as the threshold for deficiency can be deduced. As shown for the species spruce, pine and beech this method delivers values, which are in most cases very close to the known thresholds from literature. Provided that a suitable data set exists or can be set up the proposed procedure can be used to derive nutritional thresholds for species for which up to now no such values are available.
Metaphors For Trauma: A Cross‐Cultural Qualitative Comparison in Brazil, India, Poland, and Switzerland
Authors: Rechsteiner Karin , Maercker Andreas , Heim Eva , Meili Iara 
Published: April 2020

AbstractThe concept of psychological trauma implies that people experiencing traumatic stress are wounded, thus relating to the metaphor of a physical injury. Although this notion is widely accepted by clinicians and researchers in mental health, there is evidence of a broad range of metaphorical idioms for extremely aversive experiences or catastrophic events across different cultures. In this ethnopsychological study, we aimed to investigate and contrast culturally shared metaphors for trauma among four distinct cultural groups: two indigenous communities (Pitaguary from Brazil, Adivasis from India) and two rural communities (mountain villagers of Gondo, Switzerland; the Lemko ethnic minority in Poland). The communities in Brazil and in Poland were marked by historical trauma, and the communities in India and Switzerland each suffered from a natural disaster. Semistructured interviews that focused on metaphors shared within each community were conducted with key informants and laypersons (Brazil: N = 14, India: N = 28, Poland, N = 13, Switzerland: N = 9). We conducted separate metaphor analyses, then cross‐culturally contrasted the findings from the four samples. Across the four cultural groups, we found similar metaphorical concepts of trauma related to bodily processes, such as shock, burden, and wound.
Kinetics of hydroformylation of camphene using rhodium‐phosphite catalyst
Authors: Pagar Nitin S. , Rajurkar Kalpendra B. , Deshpande Raj M. 
Published: April 2020

AbstractKinetics of hydroformylation of camphene was investigated in the presence of [Rh(CO)2(acac)]/P(OPh)3 catalyst in a temperature range of 363–383 K. The influence of parameters such as stirring speed, camphene, catalyst, ligand concentrations, and partial pressures of H2 and CO on the activity and selectivity of the catalyst has been studied. The rate showed a first‐order dependence with respect to catalyst and camphene concentrations. The effect of partial pressure of hydrogen showed fractional order dependence. The plots of rate versus excess ligand, that is, (P(OPh)3) concentration and rate versus CO partial pressure passed through maxima and showed typical substrate/ligand inhibited kinetics. An empirical rate equation has been proposed and found to be in good agreement with the observed rate data. The kinetic parameters and activation energy were also evaluated.
Quality of life, social function, emotion, and facial paresis in Dutch vestibular schwannoma patients
Authors: Blom Stephanie S. A. H. , Aarts Henk , Wever Capi C. , Kunst Henricus P. M. , Semin Gün R. 
Published: April 2020

AbstractObjective(s)The present study aimed to replicate the finding that vestibular schwannoma (VS) patients with facial paresis experience lower health related quality of life (QoL) than those without facial paresis in a Dutch sample, and to extend these findings by measuring VS patients' overall satisfaction with life, social function, and emotion.MethodsForty‐seven VS patients, differing in degree of facial functioning, half of them with and half of them without a facial paresis, answered questionnaires about health related QoL (SF‐36 and PANQOL), overall satisfaction with life, fear of being evaluated negatively by others, social avoidance and distress, and characteristics and symptoms of depression.ResultsWe observed that VS patients with facial paresis experience lower health‐related QoL as well negatively impacted social function and emotion compared to VS patients without facial paresis. VS patients with facial paresis experienced lower overall satisfaction with life, more characteristic symptoms of depression, and more fear of being evaluated negatively by others than VS patients without facial paresis.ConclusionThese findings corroborate previous research showing an association between impaired facial functioning and lower QoL, but also extend them by showing differences on the quality of social function and emotion. Being aware of this difference between VS patients with and without facial paresis informs health practitioners regarding the specific support these patients might need. Moreover, it is also relevant to consider the influence of a facial paresis on patients' life when deciding between treatment options and in case of surgery the type of resection.Level of evidence3