bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh substitusi sebagian ransum komersil dengan tepung daun indigofera sp terhadap lemak abdomen ayam broiler
Authors: Putra Bela , Putra Mukhlis dwi , Pedi Utama Bopalyon 
Published: September 2020

Pakan substitusi sebagian ransum komersil dengan menggunakan indigofera sp adalah alternatif untuk memcahkan masalah mahalnya harga pakan broiler. indigofera sp memiliki keunggulan kandungan protein yang tinggi serta mudah untuk didapatkan. Penelitian ini dilaksanakan dengan tujuan untuk mengetahui pengaruh substitusi sebagian ransum komersil dengan menggunakan tepung Indigifera sp terhadap lemak abdomen ayam broiler. Penelitian ini dilaksanakan dengan metode rancangan acak lengkap dengan 5 perlakuan dan 4 ulangan, dengan rincian; perlakuan I0 (100% ransum komersil), I1 (92% komersil + 16% Indigofera sp, I3 (76% ransum komersil + 24% Indigofera sp), dan I4 (68% ransum komersil + 32% Indigofera sp). Hasil penelitian menunjukkan bahwa penggunaan Indigofera sp sebagai substitusi sebagian pakan komersil berbeda tidak nyata (P>0,05) terhadap semua parameter yang diteliti, yakni lemak abdomen, persentase lemak abdomen terhadap bobot hidup, persentase lemak abdomen terhadap karkas, persentase lemak abdomen terhadap organ dalam ayam broiler. Kesimpulan penelitian ini adalah penggunaan Indigofera sp hingga level 32% tidak mempengaruhi lemak abdomen ayam broiler.

Kata Kunci : Indigofera sp, abdomen, broiler
Faktor-faktor yang mempengaruhi kinerja usaha sapi perah rakyat di kecamatan grati kabupaten pasuruan
Authors: Hadiani Dimas Pratidina Puri , Kusumawati Enike Dwi , Nurhadi Rama Sukma 
Published: September 2020

This research was conducted at the Livestock Farming Cooperative (KUTT) of Suka Makmur on Jl. Raya Semambung Grati Desa Grati Pasuruan Regency on September 1, 2018 - September 25 2018. The purpose of this study was to determine the factors that influence the business performance of people's dairy cows in Grati District, Pasuruan Regency. The population used is dairy farmers who are members of KUTT in Grati Village, Pasuruan Regency with questionnaires as many as 100 people who take ownership of livestock under 5 heads and more than 2 dairy cows. The research method was carried out by the surve method, which is taking samples from the population of dairy farmers with a questionnaire as a data collector. The results of this study are Y = -31,729 + 0,561 X1 + 5,454 X2 + 2,087 X3 + 1,628 X4 + 8,215 X5 + (-0,117 X6) + 0,406 X7 + (-0,922 X8) +0,160 X9 and the R squared value is 0,451 this means that the business performance of dairy cows can be explained by variable X of 45.1% and the remaining 54.9% is caused by sapilactation and extensive cage factors.
The factors that influence the performance of dairy cows in the Grati farm in Pasuruan Regency, from this result the most influential variable is the number of lactation cows and cage area.
Real-time Adaptive &amp; Predictive Indicator of Deterioration (RAPID)&nbsp;A collaborative development by Birmingham Children’s Hospital,&nbsp;McLaren Applied Technologies Limited, Aston University, Isansys Lifecare Ltd &amp; University of Birmingham
Authors: Duncan Heather , Fule Balazs , Lowe David 
Published: September 2020

Abstract
1.5 million UK children are admitted to hospital every year. Approximately 650 suffer cardiac arrest and 2,900 will die in hospital. Early warning systems are recommended to reduce avoidable complications and death. To reduce or eliminate avoidable life-threatening illness developing in hospital, patients need to be identified reliably and quickly to people who can treat them effectively. We are combining the clinical expertise of a Specialist Children’s Hospital with the technology expertise of Formula One racing to monitor and care for children more effectively. This project will build upon prior work in Intensive Care where we have used McLaren Formula One technology to accentuate changes in monitored physiology and develop smart patient specific alarms (http://www.bbc.co.uk/news/technology-18997318). We will have children in the cardiac wards continuously monitored with small wireless sensors. We will combine their vital sign information with other risks related to their general health and display this combined early warning to doctors and nurses. When children are deteriorating they can quickly be identified, the required expert can be called to the bedside and, if necessary, the child could be moved to High Dependency or Intensive Care.This study is to establish that we can collect continuous remote monitoring and act on it to improve patient outcomes. The benefits to patients participating in this study will be reduced duration of stay in hospital and Intensive Care, reduced acute life-threatening events, and less anxiety about intermittent observations or deterioration.Beyond this project, we will take the technology to the rest of the hospital patients and then out of the hospital to patients at home and paramedics at the roadside.
What determines HIV self-test acceptability and uptake within the MSM community in Nairobi and its environs? A cross sectional study
Authors: Ndungu Kingori , Gichangi Peter , Temmerman Marleen 
Published: September 2020

Abstract
Background: Human Immunodeficiency Virus self-test (HIVST) refers to a process where a person collects his or her own specimen (blood or oral), performs a test and interprets the results. The interpretation of results can either be done in private or through support of a trusted partner. Self-test should be seen as screening and confirmatory test should be sort. Study Objective To determine facilitating factors for HIVST acceptability and uptake among MSM community. Methods: The researcher employed a cross-sectional exploratory study design, targeting men who have sex with men (MSM) in Nairobi. Adult men (aged 18-60 years) that reported to be actively engaging in anal or oral sex with men were eligible for the study. The researcher used purposive sampling to identify the sites where data was collected, snowballing technique was then employed to reach the respondents. Data was collected between July 2018-June 2019. A total of 391 MSM respondent were recruited to fill the self-administered questionnaires, 369 MSM completed the questionnaires (response rate = 94%). Results: There was a significant association between self-test and frequency of testing for HIV/AIDS at P-Value of 0.011. The respondents who had a positive result from the previous test were 16% and 80% of the respondents would seek confirmatory test, if tested HIV positive through HIVST. There was also a significant association between respondents who had never tested using self-test kits and the need for a testing “buddy” with a P- Value of 0.014. Fifty nine percent of the respondents would prefer blood sample test kits. High cost of the self-test kits and inadequate knowledge on the use of HIV self-test kits were the main hindrances to HIVST uptake. Conclusions: A significant number of MSM community in Kenya are willing to use HIVST and are likely to seek for care within 30 days and this is a good indicator of linkage. Blood sample kits are more preferred. Key facilitating factors for HIVST uptake include; awareness creation on HIVST, training on usage of kits, emphasis on testing ‘buddy” for first time testers and reduction on cost of the kits.
Determinants of low APGAR score in newborns delivered at Lemlem Karl general hospital, Northern Ethiopia, 2018: a case control study
Authors: Gebremedhin Mussie Mulugeta , Gebremichael Mengistu Welday , Gebremichael Berhane Gebreegizabiher , Reda Mihrete-ab Mehari , Hailu Tesfay Adhena , Gebremeskel Gebrekiros Aregawi , Tlaye Kenean Getaneh , Meikena Henok Kumsa , Yimer Nigus Bililign 
Published: September 2020

Abstract
BACKGROUND: The Apgar score is a method to quickly summarize the health of newborn children. It establishes a simple and clear classification of newborns, which could be used to predict survival and to compare methods of resuscitation and perinatal experience across hospitals and obstetric practices. Low Apgar score is associated with various immediate and long-term adverse health outcomes of newborns. Hence; in order to decrease the risk/complications, identifying the determinant factors of low Apgar is crucial to act on the modifiable risk factors. This study is aimed to investigate the determinant factors of a low Apgar score in newborn children.METHOD: The study was conducted in Lemelem Karl general hospital; northern Ethiopia. An institutional-based unmatched, case-control study was implemented. Data were retrieved from medical charts of 662 newborns’ mothers who gave birth in the hospital from Sep 2014 to Sep 2017. Among these, 221 of them were cases (charts of mothers whose newborns’ fifth minute Apgar score was <7) and 441 of them were controls (charts of mothers whose newborns’ Apgar score was 7 and above). Data was collected using a pretested and structured checklist using systematic sampling and data was entered & analyzed using SPSS version 20. Binary and multivariable logistic regression was done to determine the association and statistical significance was declared at P-value of ≤0.05. RESULTS: This study revealed that low Apgar score was significantly associated with antepartum hemorrhage [Adjusted odds ratio (AOR) 3.509; 95% confidence interval (CI) 1.526-8.067), P= 0.003], pregnancy-induced hypertensive disorders [AOR 2.69; 95% CI (1.351-5.357), P= 0.005], prolonged second stage of labor [AOR 2.63; 95% CI (1.399-4.944), P= 0.003], Cesarean delivery [AOR 2.005; 95%CI (1.223-3.287), P= 0.006],meconium-stained liquor [AOR 6.955; 95% CI (3.721-13.001), P<0.001], and low birth weight [AOR 4.38; 95% CI (2.216-8.657), P<0.001].CONCLUSION: Result from this study showed a remarkable linkage of low Apgar score with antepartum hemorrhage, pregnancy-induced hypertensive disorders, meconium-stained liquor, and low birth weight. Therefore, meticulous antenatal care and labour management service are recommended to prevent low Apgar score and the concomitant neonatal death.
Repellent effect of the caraway Carum carvi L. on the rice weevil Sitophilus oryzae L. (Coleoptera, Curculionidae)
Authors: Kłyś Małgorzata , Izdebska Aleksandra , Malejky-Kłusek Natalia 
Published: September 2020

Abstract
ObjectiveThe aim of the study was to check whether Carum carvi L. essential oil and L-carvone act on Sitophilus oryzae L. as repellents and/or insecticides, in what concentrations and after what time. ResultsCaraway essential oil and L-carvone the highest repellency showed not in the highest concentrations used in the tests (1%), but in lower concentrations, respectively 0.5% and 0.1%. Caraway essential oil in all used concentrations showed repellent effects on S. oryzae. The highest repellency (60-98%) caused caraway essential oil in concentration 0.5% after 1, 2, 3, 4 and 5 h of the research. The highest repellence of L-carvone (16-100%) resulted in concentration 0.1%. The highest mortality of S. oryzae caused 0.5% caraway essential oil.
Enhancing rhamnolipids production and exploring the mechanism of low-foaming fermentation under weakly acidic conditions
Authors: Gong Zhijin , Yang Ge , Che Chengchuan , Liu Jinfeng , Si Meiru , He Qiuhong 
Published: September 2020

Abstract
The commercial applications of rhamnolipids have seriously been impeded by the high cost of production caused by severe foaming. Effective low-foaming fermentation and mechanism study have become the most urgent requirement for the larger-scale rhamnolipids production. In this study, the low-foaming fermentation of rhamnolipids is realized by controlling fermentation at pH 5.5. Further, the rhamnolipids production is enhanced 0.9-fold by ultraviolet and ethyl methanesulfonate composite mutagenesis. To the best of our knowledge, this is the first report to enhance production of rhamnolipids by strain improvement under weakly acidic conditions. The mechanism exploration tests indicated that increasing surface tension and decreasing viscosity are conducive to reducing foaming ability of rhamnolipids fermentation. The decrease of negatively charged ions may weaken the electrostatic repulsion between charged substances adsorbed on membranes of bubbles such as rhamnolipids and cells, making liquid membranes prone to rupture. In addition, the vesicle or lamellar structures of rhamnolipids are formed under pH 5.0-6.0, weakening the foaming ability of rhamnolipids. The work reveals promising potentiality by genetic modification to enhance rhamnolipids production and is conducive to understanding the pH-associated foaming behavior as well as developing the more effective pH-associated control strategies for large-scale rhamnolipids production under weakly acidic conditions.
Perceived Support in the Shadow of Death: Near-Miss Mothers' Experience of Being Supported
Authors: Abdollahpour Sedigheh , Heydari Abbas , Ebrahimipour Hosein , Faridhoseini Farhad , Khadivzadeh Talat 
Published: September 2020

Abstract
Background: A maternal near miss (MNM) is an event in which a pregnant woman comes close to maternal death, but does not die. The aim of this study was therefore to understanding meaning of NMM lived experiences of being supported on the social and cultural context of Iran. Methods: This qualitative study utilized a hermeneutic phenomenology study. The study was conducted in in multicenter hospitals, where usually handle the NMMs. The sampling was purposeful with maximum variation of eleven NMM. Data collection used unstructured in-depth interview that analyzed with Diekelmann, Allen, and Tanner analysis approach. Results: The two main themes emerging from the data were "Perceived Social Support" and "Perceived Care Support". 910 code, eleven sub sub-theme, six sub-themes emerged, and they were grouped into two themes that help us to understand the experience of MNM mothers from supporting. Conclusions: Findings demonstrate that mother's experience of supporting, can be effective in reducing the psychological-emotional, social, economic, and cultural burden of pregnancy and childbirth complications, and future planning should aim to reduce such complications based on mother’s support. Therefore, targeted training programs, especially for the spouse, family, and medical team can be of great help to millions of near-miss mothers.
Incremental Prognostic Value of Ankle-Brachial Index in High Atherosclerosis Risk Patients: Prediction model assessment on ABILITIES Study
Authors: Cang Yan , Xu Shaojie , Ju Jingyi , Zhang Jingyin , Chen Zijun , Wang Keke , Li Jue , Xu Yawei 
Published: September 2020

Abstract
Background

Previous studies have demonstrated association between ankle–brachial index (ABI) and cardiovascular disease (CVD), and confirmed patients with high atherosclerotic risk (AR) had worse prognosis. But after controlling traditional risks, the prognostic value of ABI with all-cause mortality and CVD-cause mortality remains unclarified, especially lack of prediction model assessment.
Methods

2988 valid participants were separated into 0-0.40, 0.41–0.89, 0.90–0.99, and 1.00-1.40 four ABI subgroups, and followed up by six year. Factors related to all-cause mortality and CVD-cause mortality were observed by multivariate Cox regression analysis, log-rank test and nomogram. Restricted cubic splines (RCS) were used to explore relationship with ABI and mortality. Incremental discrimination was evaluated by net reclassification index (NRI), integrated discrimination improvement (IDI), and decision curve analysis (DCA).
Results

RCS and Kaplan–Meier survival curve all manifested abnormal ABI levels increased mortality. Compare with normal value, among 0-0.40 and 0.41–0.89 subgroup, adjusted HR of all-cause mortality was 2.12, 95% CI (1.63–3.17), and 2.06, 95% CI (1.35–2.90), respectively. HR of CVD-cuase mortality was 2.39, 95% CI (2.41–3.09), and 2.29, 95% CI (1.83–2.87), respectively. RCS presented reverse J-shaped relationship with ABI and mortality. Nomogram indicated ABI as a strong risk, occupied the second weight. Adding ABI to traditional AR model, NRI, IDI, and DCA was 0.11, 0.12, and 0.18, respectively.
Conclusion

Combining ABI with traditional AR can improve all-cause mortality and CVD mortality prediction. Routine ABI evaluation and intensive intervention were pressing needed, especially in high AR patients.
Intestinal Absorption of Geniposide and Inhibition of Transporter-P-GP Across the Caco-2 Monolayer
Authors: Bu Yanhong , wu hong , Sun MingHui , Zhang Heng , Deng Ran , Wang Yan 
Published: September 2020

Abstract
Background: Geniposide (GE) is the main bioactive component of Gardenia jasminoides Ellis, which has many pharmacological effects, such as anti-inflammatory, anti-oxidation, and anti-angiogenesis. GE has low absolute bioavailability after oral administration, and speculated that GE might have an effect on P-glycoprotein (P-gp) described in our previous study. However, intestinal absorption characteristics involved in the Caco-2 cells of GE are still unknown. Therefore, we aimed to investigate absorption mechanisms of GE and the effects on P-gp. Methods: By establishing the Caco-2 cells model and HPLC method, bidirectional transport of GE in the different conditions and the presence of P-gp inhibitors－verapamil were conducted to observe its absorption mechanisms. Transport assays of digoxin, a P-gp substrate, were also performed in the presence of GE or verapamil. The effects of GE on the function and expression of P-gp were analyzed by flow cytometry and Western blot using rhodamine-123 (rho-123) and the antibody, respectively. Results: Both absorption and secretion of GE were positively correlated with concentration and time at Caco-2 cell monolayer. The Papp of bidirectional transport was decreased in low temperature and the Papp(BL-AP) of GE decreased significantly in the presence of verapamil. Meanwhile, the ER value was higher than 1.5. In addition, in the bidirectional transport of digoxin, the values of Papp(BL-AP) and ER decreased significantly in the presence of GE, just like verapamil. GE increased the intracellular accumulation of rho-123 and also have a significant decrease on P-gp expression. Conclusion: Transepithelial transport mechanism of GE in Caco-2 cell monolayer is mainly passive diffusion and P-gp mediated active transportation. GE was a potential inhibitor of P-gp, can inhibit transport of digoxin and the function and expression of P-gp.
An Analysis of Mangrove Forest Damage Due to Illegal Logging and Its Effect on Carbon Stock and Absorption in East Java, Indonesia
Authors: Rudianto Rudianto , Bengen Dietrich G 
Published: September 2020

Abstract
BackgroundMangroves are extraordinary forests. They can protect the beach preventing soil erosion, and absorb and store carbon dioxide. Therefore, mangrove forests help decrease the concentration of carbon dioxide and a greenhouse gas in the atmosphere [1]. Mangroves are very efficient carbon sinks and store it in large quantities in the form of biomass and sediments for a long time [2]. The destruction of mangrove forests occurs because of the increasingly intensive land changes for the construction of settlements in coastal areas for both low-income and high-income populations. Also, the in-optimal management of mangrove forests by the government and the community leads to their damage. It means, the management system being implemented is not in tune with scientific findings.ResultsThe destruction of mangrove forests in East Java has occurred due to the intensification of land conversion. Accordingly, the average carbon sequestration and storage by mangroves in East Java can be classified as moderate to low. Illegal logging is the leading cause, so there needs to be a clear policy that involves the government and the community.ConclusionA strategy formulation to prevent illegal logging and increase carbon sequestration and storage has to be carried out in such a way that those responsible for the damage also compensate for it. Every community member must participate in the decision-making processes and the protection and management of mangrove forests.
BMI&nbsp;is an Independent Risk Factor for New-onset Asymptomatic Gallbladder Stone Disease in Overweight Population: A Case-control Study in Northwest China
Authors: Sheng Bin-Wu , Zhang Jianqin , Ma Mao , Zhao qingbin 
Published: September 2020

Abstract
Background: This case-control study aimed to assess associations of overweight/obesity with gallbladder stone disease (GSD).Methods: We enrolled 345 new-onset asymptomatic GSD and 690 healthy controls who had undergone annual health check-ups at the Affiliated Hospital of Xi’an Jiaotong University, in 2012-2017. Height, weight, blood pressure, serum lipid indexes and fasting blood glucose were assessed, and associations were determined by logistic multivariate regression analysis.Results: In overweight subjects, WC, BMI, WHtR, LDL-c and FBG showed significant positive correlations with GSD in univariate analysis, while HDL-c had a significant negative correlation (all P<0.05); in multivariate analysis, BMI (OR=37.738, P<0.001), WHtR (OR=1.128, P=0.042), LDL-c (OR=1.551, P=0.014) and FBG (OR=1.463, P=0.017) were significant risk factors, while HDL-c (OR=0.193, P<0.001) was a protective factor for GSD. In obese individuals, WC, BMI, WHtR, TG, LDL-c, and NAFLD showed significant positive correlations with GSD in univariate analysis, while HDL-c had a significant negative correlation (all P<0.05); BMI (OR=0.384, P=0.001) and HDL-c (OR=0.034, P<0.001) were protective factors, while WHtR (OR=2.863, P<0.001) and NAFLD (OR=4.730, P=0.037) were significant risk factors.Conclusion: BMI is an independent risk factor for new-onset asymptomatic GSD in overweight population. Meanwhile, obesity is associated with asymptomatic GSD formation with concurrent hyperlipidemia and NAFLD.
Elevated Serum Lipase Levels as a Marker of Intraductal Papillary Mucinous Neoplasm of the Pancreas: A Cross-Sectional Study
Authors: Okada Rieko , Okada Takashi , Okada Akira , Wakai Kenji 
Published: September 2020

Abstract
Background: Intraductal papillary mucinous neoplasm (IPMN) is a well-established premalignant pancreatic lesion. It is known that mild hyperlipasemia, elevated serum lipase levels, is the risk of malignancy and poor prognosis in patients with IPMN. The purpose of this study is to reveal whether hyperlipasemia is useful in identifying patients with IPMN. Methods: The consecutive 91 patients aged 40-89 years who underwent magnetic resonance cholangio-pancreatography (MRCP) from 2016 to 2019 and who showed elevated serum lipase values above the reference range (>51 U/L) in one year were enrolled. Patients were categorized into three as having IPMN, other pancreatic cystic lesion, and non-cysts groups by MRCP. Results: IPMN was found in 22% and other pancreatic cystic lesion was found in 17% of patients. The prevalence of IPMN was higher in patients with mild hyperlipasemia (60-79 U/L) compared to those with borderline hyperlipasemia (<60 U/L) (36% vs. 17%; odds ratio, 5.2; 95% confidence interval, 1.2-22.4). Patients taking H2-blockers or weight loss >1kg/year also showed higher risk of IPMN (39% vs. 15% and 32% vs. 19%, respectively), and patients with both mild hyperlipasemia and taking H2-blockers showed the highest risk of IPMN compared to those with neither of them (75% vs. 13%). Conclusions: Patients with mild hyperlipasemia showed five times higher risk of having IPMN compared to those with borderline hyperlipasemia. Further investigation with MRCP should be considered for patients with mild hyperlipasemia, especially when they had episodes of epigastric discomfort or weight loss, to find high risk patients for future pancreatic carcinoma.