bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of diagnostic codes of major clinical outcomes in a National Health Insurance database
Authors: Park Jiesuck , Kwon Soonil , Choi Eue-Keun , Choi You-jung , Lee Euijae , Choe Wonseok , Lee So-Ryoung , Cha Myung-Jin , Lim Woo-Hyun , Oh Seil 
Published: December 2019

Abstract
Background and objectives
The Korean National Health Insurance Service (NHIS) database has been widely used for cardiovascular research. We validated the primary diagnostic codes of major clinical outcomes, including acute myocardial infarction (AMI), gastrointestinal bleeding (GIB), stroke, and intracranial hemorrhage (ICH) used for Korea NHIS claims.

Subjects and methods
From 2016 to 2017, 800 patients with primary diagnostic codes of AMI, GIB, stroke, or ICH at discharge were randomly selected from a single tertiary medical center in Korea (200 patients per each diagnosis). The positive predictive value (PPV), sensitivity, and specificity of the primary diagnostic codes were calculated using hospital medical record review as the gold standard. Further improvement in the diagnostic validity of the codes was assessed by combining clinical information such as duration of hospitalization, blood transfusion, brain imaging studies, or prescription records of antithrombotic agents.

Results
Among 200 patients with AMI as the primary discharge diagnosis, 184 patients were clinically confirmed (PPV of 92.0%). For GIB, 184 (92.0%) patients with the primary discharge diagnosis were verified to have true GIB events, showing PPV of 92%. For stroke, 181 (90.5%) patients were clinically confirmed with true stroke events. For ICH, 143 (71.5%) patients were verified to be true ICH events. In stroke and ICH, the PPV and specificity improved after combining with the hospitalization duration, imaging studies, and prescription of antithrombotic agents.

Conclusions
For major clinical outcomes in the NHIS database, the primary diagnostic codes showed favorable reliability. For stroke and ICH, considerations of relevant clinical information could improve the accuracy of diagnosis.
Short tip–more function? Atrial fibrillation ablation using the novel third-generation cryoballoon in resected pulmonary vein
Authors: Chen Shaojie , Schmidt Boris , Bordignon Stefano , Bologna Fabrizio , Chun K. R. Julian 
Published: December 2019

Abstract
Background
Cryoballoon ablation is an established procedure for atrial fibrillation (AF). Patients who had previous pulmonary surgery undergoing pulmonary vein isolation (PVI) were seldom reported.

Case presentation
We describe an AF ablation using the novel short-tip third-generation cryoballoon in a patient with resected pulmonary vein. All pulmonary veins were successfully isolated without complication. The short-tip third-generation cryoballoon shows advantageous profile in PVI for AF patients with previous pulmonary surgery.

Conclusions
This report indicates that for AF patient who had previous resected PV surgery, the short-tip CB 3 provides an ideal device option for real-time PVI.
Clinicopathological features of Egyptian colorectal cancer patients regarding somatic genetic mutations especially in KRAS gene and microsatellite instability status: a pilot study
Authors: Kassem Neemat M. , Emera Gamal , Kassem Hebatallah A. , Medhat Nashwa , Nagdy Basant , Tareq Mustafa , Moneim Rabab Abdel , Abdulla Mohammed , El Metenawy Wafaa H. 
Published: December 2019

Abstract
Background
Colorectal cancer (CRC) is the third most common cause of cancer-related deaths which contributes to a significant public health problem worldwide with 1.8 million new cases and almost 861,000 deaths in 2018 according to the World Health Organization. It exhibits 7.4% of all diagnosed cancer cases in the region of the Middle East and North Africa. Molecular changes that happen in CRCs are chromosomal instability, microsatellite instability (MSI), and CpG island methylator phenotype. The human RAS family (KRAS, NRAS, and HRAS) is the most frequently mutated oncogenes in human cancer appearing in 45% of colon cancers. Determining MSI status across CRCs offers the opportunity to identify patients who are likely to respond to targeted therapies such as anti-PD-1. Therefore, a method to efficiently determine MSI status for every cancer patient is needed.

Results
KRAS mutations were detected in 31.6% of CRC patients, namely in older patients (p = 0.003). Codons 12 and 13 constituted 5/6 (83.3%) and 1/6 (16.7%) of all KRAS mutations, respectively. We found three mutations G12D, G12C, and G13D which occur as a result of substitution at c.35G>A, c.34G>T, and c.38G>A and have been detected in 4/6 (66.6%), 1/6 (16.7%), and 1/6 (16.7%) patients, respectively. Eleven (57.9%) patients had microsatellite instability-high (MSI-H) CRC. A higher percentage of MSI-H CRC was detected in female patients (p = 0.048). Eight patients had both MSI-H CRC and wild KRAS mutation with no statistical significance was found between MSI status and KRAS mutation in these studied patients.

Conclusion
In conclusion, considering that KRAS mutations confer resistance to EGFR inhibitors, patients who have CRC with KRAS mutation could receive more tailored management by defining MSI status. MSI-high patients have enhanced responsiveness to anti-PD-1 therapies. Thus, the question arises as to whether it is worth investigating this association in the routine clinical setting or not. Further studies with a larger number of patients are needed to assess the impact of MSI status on Egyptian CRC care.
Claudia Coca’s Chola Power
Authors: Daly Tara 
Published: December 2019

Abstract
This essay showcases the work of Claudia Coca, a contemporary pop artist from Lima, Peru whose paintings and drawings critique the links between race, gender, and class in a decolonial, transnational frame. First, the essay explores the way Coca celebrates the Peruvian chola by presenting herself as an empowered subject instead of as an insulted object in her paintings. While the term chola has historically been used derogatorily, Coca reappropriates her chola identity and reclaims it as her own, consequently subverting its prejudicial, racist origins. Second, the essay studies the critiques she performs of the “afterlives of colonialism” on the natural and cultural environment in her most recent series of drawings from 2017. She demonstrates that not only human bodies, but other natural materials are tangled up with the project of cultural colonization. Throughout the article, the work of Chela Sandoval is drawn on to argue that Coca practices an oppositional aesthetic that makes sensible the perspectives of subjects whose voices and bodies have been disparaged instead of valued within an uneven global capitalist system.
Listening in Arabic
Authors: Maghbouleh Neda , Omar Laila , Milkie Melissa A. , Peng Ito 
Published: December 2019

Abstract
This article reflects upon three developments emergent from a feminist approach in research with Syrian newcomer mothers in Toronto, Canada. First, a feminist approach shapes how the authors build their research team and facilitate internal meetings as a diverse, multigenerational group open to learning from others. Second, a feminist approach requires that the authors center mothers’ words through the critical practice of ensuring shared Arabic language and local knowledge in the research process. The authors offer excerpts in Arabic and English from participants’ narratives to describe how giving nuance to multiple forms of expression is key to a feminist practice of translation. Third, the authors describe how this approach opens their project to involve a range of participatory-action activities driven by the voices and desires of participants. The authors end by summarizing their ethical and methodological practices in light of inequalities at the intersection of citizenship status, class, nation, race, and other categories of asymmetrical power. These inequalities shape the authors’ attempts to reorganize conventional participant-researcher and student-faculty dynamics in their work together.
Establishment and validation of an endoplasmic reticulum stress reporter to monitor zebrafish ATF6 activity in development and disease
Authors: Clark Eric M. , Nonarath Hannah J. T. , Bostrom Jonathan R. , Link Brian A. 
Published: December 2019

ABSTRACT
Induction of endoplasmic reticulum (ER) stress is associated with diverse developmental and degenerative diseases. Modified ER homeostasis causes activation of conserved stress pathways at the ER called the unfolded protein response (UPR). ATF6 is a transcription factor activated during ER stress as part of a coordinated UPR. ATF6 resides at the ER and, upon activation, is transported to the Golgi apparatus, where it is cleaved by proteases to create an amino-terminal cytoplasmic fragment (ATF6f). ATF6f translocates to the nucleus to activate transcriptional targets. Here, we describe the establishment and validation of zebrafish reporter lines for ATF6 activity. These transgenic lines are based on a defined and multimerized ATF6 consensus site, which drives either eGFP or destabilized eGFP, enabling dynamic study of ATF6 activity during development and disease. The results show that the reporter is specific for the ATF6 pathway, active during development and induced in disease models known to engage UPR. Specifically, during development, ATF6 activity is highest in the lens, skeletal muscle, fins and gills. The reporter is also activated by common chemical inducers of ER stress, including tunicamycin, thapsigargin and brefeldin A, as well as by heat shock. In models for amyotrophic lateral sclerosis and cone dystrophy, ATF6 reporter expression is induced in spinal cord interneurons or photoreceptors, respectively, suggesting a role for ATF6 response in multiple neurodegenerative diseases. Collectively our results show that these ATF6 reporters can be used to monitor ATF6 activity changes throughout development and in zebrafish models of disease.
This article has an associated First Person interview with the first author of the paper.
Evaluating 2D and 3D serious games: The significance of student-player characteristics
Authors: Kaimara Polyxeni , Fokides Emmanuel , Oikonomou Andreas , Atsikpasi Penelope , Deliyannis Ioannis 
Published: December 2019

Τα σοβαρά παιχνίδια (ψηφιακά εκπαιδευτικά παιχνίδια μαθησιακού σκοπού) κερδίζουν ολοένα και περισσότερο το ενδιαφέρον πολλών μελετητών της μαθησιακής διαδικασίας όλων των εκπαιδευτικών επιπέδων. Σημαντικές πτυχές της εφαρμογής τους στην εκπαίδευση σχετίζονται με τα χαρακτηριστικά τους, τη συνάφειά τους με την παιδαγωγική και τις απόψεις των μαθητών. Αυτή η ποσοτική έρευνα επικεντρώθηκε στα χαρακτηριστικά των φοιτητών παιδαγωγικών τμημάτων (φύλο, επιστημονικό υπόβαθρο, προηγούμενη εμπειρία με παιχνίδια και δεξιότητες ΤΠΕ) και στους παράγοντες που επηρεάζουν και διαμορφώνουν την μαθησιακή εμπειρία τους όταν παίζουν σοβαρά παιχνίδια δύο (2D) και τριών (3D) διαστάσεων, όπως είναι η εμβύθιση, η απόλαυση, η υποκειμενική αντίληψη των μαθητών σχετικά με τη χρησιμότητά τους για τη βελτίωση της γνώσης, την επάρκεια της αφήγησης, τον ρεαλισμό, την ανατροφοδότηση, την οπτικοακουστική επάρκεια, τη συνάφειά τους με τα προσωπικά ενδιαφέροντά τους, τη σαφήνεια του στόχου τους, την ευκολία χρήσης τους, την καταλληλότητα του μαθησιακού υλικού και τα κίνητρα. Συνολικά 542 φοιτητές συμμετείχαν στη μελέτη. Σειρά μη παραμετρικών αναλύσεων (Mann-Whitney U tests και Kruskal-Wallis H tests) αποκάλυψε ότι οι φοιτητές προτίμησαν το 2D παιχνίδι. Το φύλο, το επιστημονικό υπόβαθρο και οι δεξιότητες στις ΤΠΕ δεν είχαν αντίκτυπο στις απόψεις τους. Από την άλλη πλευρά, οι φοιτητές με υψηλή ικανότητα στη χρήση των παιχνιδιών φαίνεται να έχουν καλύτερη μαθησιακή εμπειρία, καθώς οι βαθμολογίες τους στους περισσότερους παράγοντες ήταν υψηλότερες σε σύγκριση με τους φοιτητές με χαμηλότερη ικανότητα. Αυτά τα αποτελέσματα μας οδήγησαν να προσανατολιστούμε στην εξέταση άλλων πτυχών/δεξιοτήτων των φοιτητών πέρα από τα συνήθη δημογραφικά στοιχεία, όπως είναι η αυτορρύθμιση, η χωρική ικανότητα και η νοητική περιστροφή και να ερευνήσουμε τη δυνατότητα των σοβαρών παιχνιδιών να βελτιώσουν αυτές τις δεξιότητες.
Radial versus femoral access in cardiac catheterization and angioplasty. a comparative study
Authors: Mavrogianni Georgia , Karantzoula Evaggelia , Toulia Georgia , Kiriakopoulos Vasilios , Kadda Olga 
Published: December 2019

Introduction: The radial artery’s use for performing cardiac catheterization, angiography and angioplasty of the coronary vessels, is an alternative way versus the access widely utilized femoral artery.Aim: The aim of this study was to assess the potential advantages of radial versus femoral access.Material and Method: The study population was 202 patients, who were referred to coronary angiography or intervention coronary angioplasty.Statistical analysis was performed using the statistical package SPSS ver.18. For evaluation of pain was used Visual Numeric Pain Intensity Scale (visual analogue scale, VAS), which comprises using a calibrated scale of 0- 10.Results: From 1 to 30 May 2014 underwent coronary angiography in 202 patients, of whom 112 (55.4%) with RA and 90 (44.6%) with FA.Patients in the RA group showed higher VAS scores (1 ± 0.1) than those in FA group after catheterization (0.2 ± 0.4) P <0.001 + . In contrast, patients in the FA group had higher percentage of injuries / extravasations (13.3%) compared with the RA group (0.9%) P <0.001. Τhe time fluoroscopic was significantly higher in the FA (12.6 ± 10.5) compared to RA (7.6 ± 8.3) P <0.001. About the time of hospitalization, those who underwent femoral access were hospitalized significantly longer (2.6 ± 1.3) compared to patients who underwent radial access (2 ± 1.3) P <0.001+ .Conclusions: The efficacy and safety of the method in combination with the smallest rate of local complications are able to establish access way first choice in hemodynamically laboratories.
Assessment of noise pollution in operating theatre
Authors: Svardagalou Paraskevi , Kalogianni Antonia , Papageorgiou Dimitris 
Published: December 2019

Introduction: Noise is considered as a common and widespread problem in the working environment. There is a matter of noise pollution in operating theatres, which has side effects on health and working efficiency of the personnel.Aim: The assessment of the level of noise in the operating room and the analysis of the burnout and health effects of the healthcare staff working in a tertiary hospital.Material and Methods: Measurements were performed with sound meters in all three operating theatre zones during all three shifts. At the same time, the effect of noise on workers was investigated through self-completion of questionnaires during their work.Results: The results of the medical staff have shown that the workplace is noisy (59.2%) and 53.4% stated that the noise is disturbing. The majority of physicians (70%), in terms of their health effects due to noise, said they were not significantly affected, with the exception of anxiety and discomfort (40%). Relatively high professional burnout has proven in medical staff (75,7% high depersonalization and 48,6% emotional exhaustion) . As far as the responses of the nursing staff are concerned, 63% said that the workplace was noisy and 53.7% replied that the noise was disturbing. The nursing staff also stated that they are irritable (37,1%) and they feel stress(48,2%) and fatigue(72,2%). The professional burnout of nurses was also high (59,3% high depersonalization and 61,1% emotional exhaustion) . Statistically significant differences were found between medical and nursing staff in assessing exposure to noise and the symptoms caused by it, with nursing staff being more influenced by operating room noise (p≤0.05). Differences were also found among workers in different operational zones and specialties (p≤0.05).Conclusions: The results suggest the presence of noise pollution with impact on working performance. Noise effected health staff in a negative way due to specialty, different operational zone and burn out levels.
Severity and mortality of patients undergoing continuous haemodiafiltration in the icu
Authors: Fegari Kasiani , Rikos Nikolaos , Vasilopoulos Georgios , Marvaki Christina 
Published: December 2019

Εισαγωγή: Ανεξάρτητα από την πρωτοπαθή νόσο η οξεία νεφρική βλάβη(ΟΝΒ) αποτελεί επιπρόσθετο επιβαρυντικό παράγοντα που αυξάνει τη νοσοκομειακή θνητότητα και βαρύτητα. . Έχει υπολογιστεί ότι στους ασθενείς της Μονάδας Εντατικής Θεραπείας (ΜΕΘ) που βρίσκονται σε μηχανική υποστήριξη της αναπνοής, ένα ποσοστό από 5%-35% θα εμφανίσει σε κάποια φάση της νοσηλείας του κάποιου βαθμού οξεία νεφρική ανεπάρκεια, η οποία σχετίζεται με θνητότητα που ξεπερνά το 20%.Σκοπός: Σκοπός της παρούσας ερευνητικής μελέτης είναι η διερεύνηση της βαρύτητας και θνητότητας των ασθενών που υποβάλλονται σε συνεχή αιμοδιαδιήθηση σε ΜΕΘ.Υλικό και Μέθοδος: Η μελέτη είναι μία περιγραφική ανάλυση όλων των ασθενών που υπεβλήθησαν σε συνεχή αιμοδιαδιήθηση στη ΜΕΘ μεταξύ Απριλίου 2017 και Δεκεμβρίου 2017. Καταγράφηκαν δημογραφικά στοιχεία όπως ηλικία, φύλο διάγνωση εισαγωγής, διάρκεια νοσηλείας και έκβαση. Επίσης καταγράφηκε η διάρκεια της κάθε συνεδρίας αιμοδιαδιήθησης καθώς και ειδικά κλινικά δεδομένα που αφορούσαν τη θεραπεία νεφρικής υποκατάστασης.Αποτελέσματα: Το δείγμα αποτέλεσαν 33 ασθενείς (32,3%) οι οποίοι υπεβλήθησαν σε συνεχή αιμοδιαδιήθηση (CVVHDF)το χρονικό διάστημα της μελέτης. Η μέση ηλικία του δείγματος ήταν τα 72,7+ 9,46 έτη, Η διάμεση διάρκεια νοσηλείας ήταν 16,5 ημέρες (1-91 ημέρες). ενώ μέση τιμή στο APACHE II των ασθενών κατά την εισαγωγή ήταν 28,5 +9,08. Η θνητότητα στο υπό μελέτη δείγμα ανήλθε στο 60,6%.Συμπεράσματα: Το υψηλό κόστος της μεθόδου καθώς και το υψηλό ποσοστό θνητότητας των ασθενών, καθιστά αναγκαίο τον προσδιορισμό σαφών κριτηρίων εφαρμογής της μεθόδου, συνεχούς αξιολόγησης και εκτίμησης της αποτελεσματικότητας αυτής, καθώς και συνεχή εκπαίδευση του προσωπικού στη χρήση αντίστοιχων τεχνολογιών.
Case-management for nursing care of patient with stroke: a cross-cultural critical reflective analysis
Authors: Theofanidis Dimitrios 
Published: December 2019

Introduction: Stroke remains a heavy financial burden on health care systems around the world. Yet, health care reforms have called for sophisticated management systems in order to provide high-quality care on equal terms for the entire population within a cost-conscious environment. Aim: The main aim of this discussion paper is to define and reflect cross-culturally on the merits of the Case-Management (CM) approach for contemporary stroke care delivery.Methods: Critical reflective analysis was used for this paper’s needs, whereby readers are gradually introduced to skills of critical and reflective thinking. This can then be applied into a clinical context which may assist nurses to achieve a better understanding of their professional role within the complexities of contemporary health care delivery.Discussion: An overview for stroke care differences between Greece and USA is provided using the following critical analysis components: Situation, Experience evaluated, Personal Reflections and Opportunities for Change.Conclusions: CM in the USA aims to meet the urgent challenges of stroke care. CMs are health care professionals whose role is to serve as client advocates and to coordinate services whilst assuring financial and gate keeping functions as required. As these services are currently unavailable in Greece, despite adverse financial circumstances, efforts should be made to introduce a culturally adopted CM initiative for stroke care.
Attitudes and perceptions of health professionals towards mental patients attending emergency room
Authors: Douki Stamatina , Marvaki Christina , Toulia Georgia , Stavropoulou Areti 
Published: December 2019

Introduction: Mental health patients are a group of population that has predominantly been stigmatized throughout the centuries. Aim: The aim of the present study was to explore attitudes of health professionals in the emergency department towards the mentally ill.Material and Methods: The sample of the study consisted of 278 health professionals working in Emergency Departments. A questionnaire scale O.M.I. (Opinion about Mental Illness) was used for data collection. Data analysis was performed with the statistical package Statistical Package for Social Sciences (SPSS) ver.22.Results: The correlation of five O.M.I. scale factors there is no statistically significant relationship (p-value> 0.05) with the variables sex and years of employment. Age had a statistically significant relationship (p-value=0.034) with the factor "social integration" and has no statistically significant relationship (p-value> 0.05) with the remaining factors O.M.I. scale ("Social discrimination", "social constraint", "social care" and "ground"). In association with education there is a statistically significant relationship with the agents 'social discrimination'(p-value<0.001), 'social restriction'(p-value=0.001), and "ground"(p-value=0.045) and there statistically significant relationship (p-value> 0.05) with the "social inclusion"(p-value<0.001) and "social care" specialty.The variable has a statistically significant difference (p-value <0.05) the factor "social distinction” (p-value<0.001) between doctors andnurses, in the "social restriction 'among doctors and nurses and between nurses and other disciplines and the factor "social integration"(p-value<0.001) between physicians-nurses and doctors with other specialties.Conclusions: The statistical analysis of the questionnaires (O.M.I. scale) distributed showed that the variables age, educational level, specialty affect the attitudes and perceptions of health professionals towards the mentally ill (negative stops), which form the stigma of mental illness.
Benchmarkıng ındıcators nursing workload ın Intensıve Care Unıts
Authors: Kollia Thomai , Argyriou Georgios , Prevyzi Evangelia , Nestor Athanasia , Kotanidou Anastasia , Marvaki Christina 
Published: December 2019

Introduction: The high and continues increasing nursing workload in the Intensive Care Unit (ICU) is a remarkable increase in mortality factor of heavy ill patients.Aim: The aim of this study was a comparison evaluation between the score of Nursing Workload (NW), Nursing Activity Score (NAS) and Comprehensive Nursing Intervention Score (CNIS) in nurses who treat critically ill patients in Intensive Care Unit (ICU).Material and Methods: The studied population was 100 patients who were hospitalized in Intensive Care Units (ICU) hospitals in Athens and private clinic of Piraeus. It was used a special designed questionnaire by the researchers based on Nursing Activity Score (NAS) score and Comprehensive Nursing Intervention Score (CNIS) score. Data analysis was performed with the statistical package SPSS 17.0.Results: The 56% of study were men. The average age of the sample was 74 ± 15 years. The average Nursing Activity Score (NAS) for the first 10 days of hospitalization was 55, 4 ± 4, 9 and Comprehensive Nursing Intervention Score (CNIS) was 129, 5 ± 15, 4. Compared with indicators gravity nursing workload, with prognostic score APACHE II, SAPS II, the Glasgow scale and with laboratory markers creatinine and white blood showed that the Nursing Activity Score (NAS) and Comprehensive Nursing Intervention Score (CNIS) indicators a statistically significant difference (p = 0.005 and p <0.001, respectively) compared with patient outcome.Conclusions: The nursing workload (NW) as measured on scales Nursing Activity Score (NAS) and Comprehensive Nursing Intervention Score (CNIS). Both scales are equality and validity. Similarly, the outcome of these patients was associated with disease severity as measured by the score APACHE II and SAPS II.