bluuebunny/crossref_metadata_2025_split huggingface dataset:
Career Counselling Effectiveness and Contributing Factors
Authors: Whiston Susan C. 
Published: July 2020

Abstract
This chapter explores the research related to whether career counselling is effective for individuals with vocational issues. In particular, there is considerable empirical support for career counselling related to career choice issues and searching for employment. Hence, practitioners can use this evidence to convince administrators, policymakers, parents, students, and other constituencies of the worth of career counselling. In addition, the chapter provides empirical evidence that practitioners can use to improve their effectiveness in working with people with career issues. This discussion mainly focuses on the results from older and newer meta-analyses regarding the ingredients that have a significant influence on effect sizes or the critical ingredients in career counselling. For example, there is considerable evidence that support from individuals, including the counsellor, may play an important role in the effectiveness of career counselling. Other factors that contribute to effective practice are also identified and discussed. The chapter further explores the need for additional research that addresses the most effective methods for providing career counselling. As the world of work becomes increasingly complex, it is important that researchers continue to explore the most effective strategies for assisting people in finding satisfying, meaningful, and productive work.
Fair Trade Music?: Ethical Consumerism and the Political Economy of Digital Music
Authors: Wagner Tom 
Published: July 2020

Abstract
This chapter explores how the music creators group Fair Trade Music International (FTMI) applies the ethos and methods of Fair Trade in attempts to reform how, and how much, music creators are paid for digital music sales. The term “Fair Trade” has since the 1980s become synonymous with “ethical consumerism,” a set of ideals and practices that seek to mitigate the deleterious effects of “unethical” capitalism. Yet the overall effects of “ethical consumerism” itself are debatable: on the one hand, it often improves the material conditions of producers, especially in the “global south.” On the other hand, it does so within—and therefore reinforces—the existing political-economic structures that produce what it seeks to mitigate. How does this paradox manifest in the context of digital music sales?
Posttraumatic Stress Disorder and the Gut Microbiome
Authors: Loupy Kelsey M. , Lowry Christopher A. 
Published: July 2020

Abstract
Posttraumatic stress disorder (PTSD) is a trauma- and stressor-related disorder that is often associated with the dysregulation of multiple physiological systems, including autonomic nervous system functioning, glucocorticoid signaling, and chronic low-grade inflammation. Recent evidence suggests that persons with a diagnosis of PTSD also exhibit alterations in the composition of gut microbiomes compared to people who are trauma-exposed but do not develop PTSD. The bidirectional communication between the gut microbiome, the gut, and the brain, deemed the microbiome-gut-brain (MGB) axis, is composed of neural, neuroendocrine, and immune processes that both impact and respond to the structure of the gut microbiome. This chapter aims to outline (1) the ways in which trauma and stressor exposure may impact the gut microbiome; (2) the ways in which gut microbiome composition may influence brain function, including anxiety, and fear responses; and (3) how the bidirectional MGB axis, through interactions with several physiological circuits, may determine individual variability in resilience versus vulnerability to development of PTSD after trauma exposure.
Improved method for measuring low-concentration radium and its application to the Super-Kamiokande Gadolinium project
Authors: Ito S , Ichimura K , Takaku Y , Abe K , Harada M , Ikeda M , Ito H , Kishimoto Y , Nakajima Y , Okada T , Sekiya H 
Published: July 2020

Abstract
Chemical extraction using a molecular recognition resin named “Empore Radium Rad Disk” was developed to improve sensitivity for the low concentration of radium (Ra). Compared with the previous method, the extraction process speed was improved by a factor of three and the recovery rate for $^{226}$Ra was also improved from $81\pm4\%$ to $&gt;99.9\%$. The sensitivity on the $10^{-1}$ mBq level was achieved using a high-purity germanium detector. This improved method was applied to determine $^{226}$Ra in Gd$_2$(SO$_4$)$_3{\cdot}$8H$_2$O which will be used in the Super-Kamiokande Gadolinium project. The improvement and measurement results are reported in this paper.
Comparison of Perimodiolar Electrodes: Imaging and Electrophysiological Outcomes
Authors: Mewes Alexander , Brademann Goetz , Hey Matthias 
Published: July 2020

Background:
The perimodiolar CI532 Slim Modiolar electrode has been designed to bring the electrode contacts close to auditory nerve while reducing cochlear trauma during its insertion. It is currently unknown to what extent the electrode position and electrophysiological outcomes of the Slim Modiolar electrode differ from other perimodiolar electrodes.

Objectives:
The objective was to compare the electrode position and electrophysiological outcomes between the CI532 Slim Modiolar and CI512 Contour Advance electrode.

Method:
Forty-six adult patients received a Slim Modiolar or Contour Advance electrode. Electrode types were compared using intraoperative electrode impedances, evoked compound action potential (ECAP) and stapedius reflex thresholds, as well as position parameters from postoperative computed tomography or digital volume tomography images (medial-lateral position, electrode-to-modiolus distance, insertion angle).

Results:
The medial-lateral position indicates a closer modiolar placement of the Slim Modiolar compared with the Contour Advance. Individual electrode contact measurements, however, showed significantly larger electrode-to-modiolus distances and higher ECAP thresholds for the Slim Modiolar in the basal region. On contacts E20–22 the Slim Modiolar is slightly closer to the modiolus compared with the Contour Advance, but this did not result in lower ECAP thresholds.

Conclusions:
Perimodiolar electrodes can vary in their intracochlear position, leading to divergent electrophysiological outcomes. To detect these differences, investigations must be done for each electrode contact rather than using a global factor for the whole electrode array. While the electrode dislocation rate is lower with the Slim Modiolar than with the Contour Advance, electrode-to-modiolus proximity is smaller and ECAP thresholds are lower with the Contour Advance in the basal cochlear region.
Pediatric cystic lymphangioma of the retroperitoneum
Authors: Poroes Fabio , Petermann David , Andrejevic-Blant Snezana , Labgaa Ismail , Di Mare Luca 
Published: July 2020

Abstract

Rationale:
Cystic lymphangioma (CL) is a rare benign tumor resulting from a failure of the lymphatic system development. It may occur at any age but it is more frequent during childhood. Its clinical presentation and location are various but abdominal CL are uncommon. Among those, mesenteric presentation is the most frequent form whereas CL of the retroperitoneum are particularly rare.

Patient concerns:
Herein, we report the case of a 17-years-old patient with no medical history who presented with right-upper quadrant (RUQ) pain, but no other symptom. Physical examination showed tenderness of the RUQ without distension. Lab tests were unremarkable.

Diagnosis:
Abdominal computed tomography (CT) highlighted a retroperitoneal cystic mass potentially infiltrating the mesenterium, raising suspicion of a CL of the retroperitoneum. Diagnosis of CL was confirmed by histological analyses.

Intervention:
Patient underwent an exploratory laparoscopy that infirmed infiltration of the mesenterium and allowed for resection.

Outcomes:
Postoperative course was uneventful and there is no evidence of recurrence after 14 months of follow-up.

Lessons:
Although CL essentially occur in children, pediatric retroperitoneal CL is a rare finding, with only 21 cases identified in the literature.
In summary, CL are benign tumors rarely located in the retroperitoneum. Despite performant imaging technologies, preoperative diagnosis is challenging. Whenever possible, laparoscopic resection should be the treatment of choice. Herein, we report the largest CL pediatric case laparoscopically resected, and the first review of the literature on the topic.
The predictive value of calcification for the grading of ductal carcinoma in situ in Chinese patients
Authors: Kong Jianchun , Liu Xiaomin , Zhang Xiaodan , Zou Yu 
Published: July 2020

Abstract
High-grade ductal carcinoma in situ (DCIS) requires resection due to the high risk of developing invasive breast cancer. The predictive powers of noninvasive predictors for high-grade DCIS remain contradictory. This study aimed to explore the predictive value of calcification for high-grade DCIS in Chinese patients.
This was a retrospective study of Chinese DCIS patients recruited from the Women's Hospital, School of Medicine, Zhejiang University between January and December 2018. The patients were divided into calcification and non-calcification groups based on the mammography results. The correlation of calcification with the pathologic stage of DCIS was evaluated using the multivariable analysis. The predictive value of calcification for DCIS grading was examined using the receiver operating characteristics (ROC) curve.
The pathologic grade of DCIS was not associated with calcification morphology (P = .902), calcification distribution (P = .252), or breast density (P = .188). The multivariable analysis showed that the presence of calcification was independently associated with high pathologic grade of DCIS (OR = 3.206, 95% CI = 1.315–7.817, P = .010), whereas the age, hypertension, menopause, and mammography BI-RADS were not (all P > .05) associated with the grade of DCIS. The ROC analysis of the predictive value of calcification for DCIS grading showed that the area under the curve was 0.626 (P = .019), with a sensitivity of 73.1%, specificity of 52.2%, positive predictive value of 72.2%, and negative predictive value of 53.3%.
The presence of calcification is independently associated with high pathologic grade of DCIS and could predict high-grade DCIS in Chinese patients.
A 12 week, randomized, double-blind, placebo-controlled clinical trial for the evaluation of the efficacy and safety of HT083 on mild osteoarthritis
Authors: Lee Donghun , Kim Seok Jung , Kim Hocheol 
Published: July 2020

Abstract

Background:
The increasing prevalence of osteoarthritis among the old population worldwide is a great concern. Two of the biggest complaints of OA patients are joint pain and inflammation. Currently, people are relying on non-steroidal anti-inflammatory drugs (NSAIDs) and steroids to control pain and inflammation. However, long-term use of these pharmaceutical drugs has negative health consequences in the elderly, including gastro-intestinal, respiratory, and renal diseases. Natural products are receiving more attention than ever as alternative treatments against OA for their efficacies and safety. The root of Paeonia lactiflora Pal and the gum resin of Commiphora myrrha have been used as analgesics and anti-inflammatory agents since ancient time. A new herbal formula composed of P. lactiflora root and C. myrrha gum resin extracts, known as HT083, has shown promising antinociceptive and anti-inflammatory effects in a rodent model of OA. We design this study to investigate the safety and the efficacy of HT083 to prevent OA in patients with mild OA.

Methods:
This is a randomized, double-blind, and placebo-controlled study. A total of 100 eligible participants will be divided into two groups and will be given HT083 and a placebo for 12 weeks in 1:1 ratio. Treatment results will be assessed using a visual analog scale (VAS), Korean-Short Form health survey-36 score (SF-36), personal evaluation, and laboratory analysis.

Discussion:
This trial is expected to provide clinical evidence on the effectiveness and the safety of HT083 as a natural treatment for mild OA.

Trial registration:
Korean Clinical Research Information Service (CRIS) number KCT0004925 Registered on 2020.04.16.
Efficacy and safety of moxibustion for patients with functional constipation
Authors: Chen Ying , Xu Mingmin , Hou Tinghui , Wang Lu , Feng Xiumei , Li Ying 
Published: July 2020

AbstractIntroduction:The objective of this review is to assess the efficacy and safety of moxibustion for treating patients with functional constipation (FC).Methods and analysis:We will electronically search the following databases: OVID MEDLINE, EMBASE, PubMed, Web of Science, the Cochrane Central Register of Controlled Trials, Cochrane library, CINAHL, AMED, China Network Knowledge Infrastructure, Wan-fang Database, China Biomedical Literature Database, and other resources from inception to October 2019, without any language restrictions. Randomised-controlled trials will be included. The primary outcome is the improvement in mean complete spontaneous bowel movements and stool form (utilize the Bristol Stool Form Scale [BSFS]). Secondary outcomes involve the degree of difficulty in defecation, proportion of responders, mean transit time, health-related quality of life, and adverse events rate. The methodological quality will be assessed using the Cochrane risk of bias tool.Results:This work will summarize clinical evidence to assess the effectiveness and safety of moxibustion treatment for FC patients.Conclusion:This systematic review and meta-analysis will provide current evidence of the efficacy and safety of moxibustion treating FC.Systematic review registration:PROSPERO, CRD42020157955.
Risk of rectal puncture due to needle entry into the presacral space
Authors: Kwon Young Suk , Lee Narea , Lee Ho Seok , Youn Eun Ji , Lee Soo Kyung , Kim Youngmi , Lee Jae Jun 
Published: July 2020

AbstractDuring ganglion impar block, the needle may approach the presacral space and the sacrum may be penetrated during caudal anesthesia. Because the rectum is in front of the sacrococcyx and is thus at risk for puncture, it is important to determine the distance between the sacrococcyx and rectum, as well as the thickness of the sacrococcyx.Computed tomography was used to measure the distance between the rectum and sacrococcyx, as well as the thickness of the sacrococcyx. The distances between the coccyx and rectum, sacrococcygeal joint and rectum, sacral level 5 (‘sacrum 5’) and rectum, and ‘sacrum 4 to 5 junction’ and rectum were measured. The results were compared based on the presence or absence of stools in the rectum. The thickness of the sacrococcyx was measured at the sacrum 4 to 5 junction and sacrococcygeal joint.In total, 1264 patients were included in this study. All distances were less than 1 mm in both males and females, with the exception of the distance between the coccyx and rectum in males. In both males and females, there was no significant difference in distance between the sacrococcyx and rectum according to the presence or absence of feces in the rectum, but there was a difference in the distance between sacrum 5 and the rectum in males (P = .048). Several male and female patients showed thicknesses of less than 5 mm at the sacrococcygeal joint.Some patients have a distance of less than 1 mm between the sacrum and rectum. Practitioners should exercise caution when applying a needle to the presacral space. If the sacrum is accidentally penetrated during caudal block, rectum puncture cannot be ruled out. Excretion of feces does not influence the distance between the sacrococcyx and rectum in females.
Cost-utility of new film-coated tablet formulation of deferasirox vs deferoxamine among major beta-thalassemia patients in Iran
Authors: Saiyarsarai Parisa , Khorasani Elahe , Photogeraphy Hasti , Ghaffari Darab Mohsen , Seyedifar Meysam 
Published: July 2020

Abstract

Objectives:
Thalassemia is a hereditary disease, which caused economic burden in developing countries. This study evaluated the cost utility of new formulation of deferasirox (Jadenu) vs deferoxamine (Desferal) among B-Thalassemia-major patients from payer perspective in Iran.

Methods:
An economic-evaluation through Markov model was performed. A systematic review was conducted in order to evaluate the clinical effectiveness of comparators. Because of chelating therapy is weight-dependent, patients were assumed to be 2 years-old at initiation in first and 18 years-old in second scenario, and model was estimated lifetime costs and utilities. Costs were calculated to the Iran healthcare system through payer perspective and measured effectiveness using quality-adjusted life years (QALYs). One-way sensitivity analysis and budget impact analysis was also employed.

Results:
The 381 studies were retrieved from systematic searching through databases. After eliminating duplicate and irrelevant studies, 2 studies selected for evaluating the effectiveness. Jadenu was associated with an incremental cost-effectiveness ratio (ICER) of 1470.6 and 2544.7 US$ vs Desferal in first and second scenario respectively. The estimated ICER for Jadenu compared to generic deferoxamine was 2837.0 and 6924.1 US$ for first and second scenario respectively. For all scenarios Jadenu is presumed as cost-effective option based on calculated ICER which was lower than 1 gross domestic product per capita in Iran. Sensitivity analysis showed that different parameters except discount rate and indirect cost did not have impact on results. Based on budget impact analysis the estimated cost for patients using Desferal (based on the market share of brand) was 44,021,478 US$ in 3 years vs 42,452,606 US$ in replacing 33% of brand market share with Jadenu. This replacement corresponded to the cost saving of almost 1,568,872 US$ for the payers in 3 years. The calculated cost of using generic deferoxamine in all patients was 68,948,392 US$. The increase in the cost of using Jadenu for 10% of all patients in this scenario would be 934,427 US$ (1.36%) US$ at the first year.

Conclusions:
Based on this analysis, film-coated deferasirox appeared to be cost-effective treatment in comparison with Desferal for managing child and adult chronic iron overload in B-thalassemia major patients of Iran.
Prognostic factors for venous thrombosis in patients with peripherally inserted central catheters
Authors: Gao Yanling , Fan Xiaoyi , Han Jie 
Published: July 2020

Abstract

Background:
Peripherally inserted central catheters (PICCs) has become increasingly popular in clinical practice because of the ease and safety of insertion and lower cost-effectiveness. The precise incidence and risk of PICC-related venous thrombosis is important to be verified in the context of growing PICC use and an understanding of the risk of venous thrombosis is an important cost and patient safety question.

Method:
We will search seven electronic databases including the Cochrane Library, MEDLINE, EMBASE, Chinese BioMedical Database, China National Knowledge Infrastructure, Chinese VIP and Wangfang Database regardless of publication date or language. All studies with prognostic factor analysis will be included if they recruited participants with PICC. Primary outcomes will include venous thrombosis. The risk of bias will be assessed by 2 authors using quality in prognostic studies tool. If possible, a meta-analysis in fixed or random effects model will be conducted by R-3.5.1 software, otherwise a narrative synthesis will ensue focusing on prognostic factors. The confidence in cumulative evidence will be assessed by Based on the Grading of Recommendations Assessment, Development and Evaluation.

Results:
The aim of this study is to retrieve, appraise and summarize the clinical evidence of risk assessment for PICC-related venous thrombosis.

Conclusions:
This study will assess the precise incidence and risk of venous thrombosis in patients with PICC and provide references for establishing relevant assessment tools.

Ethics and dissemination:
This study is a protocol for systematic review and meta-analysis of prognostic factors for venous thrombosis in PICC patients. This review will be published in a journal and disseminated in print by peer-review.
Mean platelet volume and mean platelet volume/platelet count ratio in nonvalvular atrial fibrillation stroke and large artery atherosclerosis stroke
Authors: Zhu Ning , Shu Hao , Jiang Wenbing , Wang Yi , Zhang Shunkai 
Published: July 2020

Abstract
Ischemic stroke subtypes such as patients with large artery atherosclerosis, cardioembolism, and embolic stroke of undetermined source were investigated. This study was performed aimed to determine mean platelet volume (MPV) and mean platelet volume/platelet count (MPV/Plt) ratio in nonvalvular atrial fibrillation (AF) stroke and large artery atherosclerosis (LAA) stroke.
We conducted a retrospective study of consecutive patients for treatment of acute ischemic stroke at Ruian People's Hospital from March 2017 to October 2018. The patients with ischemic stroke caused by AF and LAA were recruited to this study. Ischemic stroke was confirmed by magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA), ischemic lesions on diffusion-weighted imaging were measured in terms of size, composition, and pattern. MPV and platelet count were examined and (MPV/Plt) ratio was calculated.
Three hundred seventy one patients were enrolled composing of 177 (47.7%) nonvalvular AF and 194 (52.2%) with LAA. The MPV (11.3 ± 1.3 vs 10.8 ± 1.0, P < .001) and MPV/Plt ratio (0.066 ± 0.025 vs 0.055 ± 0.20, P < .001) were much higher in AF group than LAA group. Receiver-operating characteristic (ROC) analysis showed MPV (AUC: 0.624, confidence interval: 0.567–0.68, P < .001) and MPV/Plt (AUC: 0.657, confidence interval: 0.601–0.713, P < .001) predicted AF between the 2 groups. MPV/Plt ratio was negatively associated with lesion volume (r = –0.161, P = .033) in AF. The analyses of subtypes of composition of infarcts and infarct pattern showed that MPV/Plt ratio was almost higher in AF than LAA except for subcortical-only pattern. Multivariable regression analyses demonstrated National Institutes of Health Stroke Scale (NIHSS) score (r = 2.74; P < .001), LAD (r = –1.15; P = .025) and MPV/Plt ratio (r = –180.64; P = .021) were correlated with lesion volume.
Our results indicated elevated MPV and MPV/Plt ratio for the identification of difference between AF and LAA in patients with ischemic stroke.
Acupuncture plus rehabilitation for post-stroke depression
Authors: Hou Yonghui , Zhang Ning , Hao Jieming , Wang Xiangzhi , Wen Zehuai , Luo Ding , Ning Baile , Fu Wenbin , Liu Ying 
Published: July 2020

Abstract

Background:
Post-stroke depression (PSD) is a common stroke complication that is characterized by hopelessness, anxiety, disordered sleep, and lowered responsiveness. Rehabilitation and acupuncture treatments are often combined to treat PSD; however, there has been no meta-analysis on their synergistic effect. Therefore, we aim to perform a systematic review and meta-analysis to estimate the effectiveness of acupuncture and rehabilitation in PSD treatment.

Methods:
We will search the following electronic databases: PubMed, the Cochrane Library, EMBASE, the China National Knowledge Infrastructure, the Chinese Biomedical Literature Database, China Science and Technology Journal Database, and Wan Fang databases. We will include studies published between the database initiation and May 2020. Two reviewers will separately conduct study selection, data extraction, and risk of bias assessment. Disputes will be settled by consulting a third reviewer. Review Manager Software 5.3 will be employed for this meta-analysis.

Results:
This systematic review will assess whether acupuncture combined with rehabilitation treatment is more effective than rehabilitation alone in the management of PSD.

Conclusion:
This systematic review will provide evidence regarding the synergistic effect of acupuncture and rehabilitation treatment for PSD.