bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying and understanding factors that affect the translation of therapies from the laboratory to patients: a study protocol
Authors: Lalu Manoj M. , Montroy Joshua , Begley C. Glenn , Bubela Tania , Hunniford Victoria , Ripsman David , Wesch Neil , Kimmelman Jonathan , Macleod Malcolm , Moher David , Tieu Alvin , Sikora Lindsey , Fergusson Dean A. 
Published: October 2020

Background: The process of translating preclinical findings into a clinical setting takes decades. Previous studies have suggested that only 5-10% of the most promising preclinical studies are successfully translated into viable clinical applications. The underlying determinants of this low success rate (e.g. poor experimental design, suboptimal animal models, poor reporting) have not been examined in an empirical manner. Our study aims to determine the contemporary success rate of preclinical-to-clinical translation, and subsequently determine if an association between preclinical study design and translational success/failure exists. Methods: Established systematic review methodology will be used with regards to the literature search, article screening and study selection process. Preclinical, basic science studies published in high impact basic science journals between 1995 and 2015 will be included. Included studies will focus on publicly available interventions with potential clinical promise. The primary outcome will be successful clinical translation of promising therapies - defined as the conduct of at least one Phase II trial (or greater) with a positive finding. A case-control study will then be performed to evaluate the association between elements of preclinical study design and reporting and the likelihood of successful translation. Discussion: This study will provide a comprehensive analysis of the therapeutic translation from the laboratory bench to the bedside. Importantly, any association between factors of study design and the success of translation will be identified. These findings may inform future research teams attempting preclinical-to-clinical translation. Results will be disseminated to identified knowledge users that fund/support preclinical research.
Crystallographic features of oral fluid in young people with gingivitis
Authors: Vadzyuk S. , Boliuk Yu. , Luchynskyi M. , Sluchyk V. , Zukow W. 
Published: October 2020

Introduction. Oral fluid is involved in maintaining the homeostasis of hard and soft tissues of the oral cavity. Therefore, it can indicate the changes in both the local environment and the whole organism. Recently, the crystallographic features of oral fluid have been actively studied. Therefore, this paper is devoted to the possibility of using crystallographic patterns of oral fluid for the early diagnosis of periodontal diseases in young people under 30 years of age.The purpose of the research is to study the crystallographic picture of oral fluid in subjects aged 18-23 years with gingivitis.Materials and methods. Subjects were divided into two groups: main — with chronic catarrhal gingivitis (28) and control (32). The main group consisted of two subgroups — with mild (18) and moderate (10) gingivitis. The degree of gingivitis was determined using the papillary-marginal-alveolar index (PMA) in Parma modification (1960). The study of oral fluid was performed using the method of wedge-shaped dehydration. The type of crystallization was determined according to the method of Leus P. A. modified by Dubrovina L. A. (1989).Results and discussion. The type II crystallization of oral fluid was observed in the majority of individuals in both groups. Type II of the main group was characterized by massive crystals and minor crystals, smaller in size, and of different shapes. Type III was detected only in subjects with gingivitis. 75,00 % of representatives with mild gingivitis have had type II of crystallization patterns. Again, type III of oral fluid facies was observed only in moderate gingivitis.Conclusions. Dependence of the crystallization type of oral fluid on the severity of the inflammatory process can be used in the development of methods for early diagnosis and prevention of periodontal pathology progression.
Impact of coffee on human health
Authors: Szuster Ewa , Pawlikowska Anna , Mandera Amanda , Kostrzewska Paulina 
Published: October 2020

Coffee is considered as one of the most popular beverages in the world. There are many different methods of preparation which can change the taste but also it could limit the level of dipertenes which raise blood cholesterol. For many years it was thought that the impact of coffee on human health is not very positive. Surprisingly coffee consumption is associated with lower risk of the type 2 diabetes mellitus and lower cancer risk. It also decreases mortality from cardiovascular disease, coronary heart disease, and stroke. Summarizing, the results of the analyzed studies show positive impact of coffee on human health. To maintain the advantages of this beverage, amount of caffeine, intake of sugar or cream should be limited.
Methods of contraception for men
Authors: Łopuszyńska Anna Małgorzata , Pawlicki Mateusz , Piekarska Ewa , Kozioł Magdalena , Krasa Aleksandra , Piecewicz-Szczęsna Halina 
Published: October 2020

Many pregnancies in the world are unintentional and some of them end in abortion, hence there is a great need and amount of research on contraceptives. There are many methods of pregnancy prevention for women. However, men also want to be responsible for their reproductive health. Currently, there are few methods of contraception for men (male condoms, vasectomy, withdrawal) and they have their drawbacks, so research on new contraceptives for men is ongoing. Hormonal methods under research include testosterone, nestorone, and DMAU. On the other hand, adjudin, WIN 18.446, BMS-189453 and RISUG are promising methods of non-hormonal male contraception. These substances can be a discovery and a breakthrough in male contraception, they will allow men to better control their fertility and reproductive health, and can also be a suitable solution for couples in which there are contraindications for women to use contraception.
Risk factors of ovarian cancer: family history, obesity and oral contraceptive use
Authors: Kuchnicka Aleksandra Amalia , Zielińska Martyna , Zarankiewicz Natalia , Kosz Katarzyna , Piecewicz-Szczęsna Halina 
Published: October 2020

Introduction and purpose: Ovarian cancer (OC) takes the 7th place among most common female malignancies worldwide. There are almost 240 thousand of new cases diagnosed each year and the number is constantly growing. Defining risk factors of OC is essential to provide good education among women and predict this malignancy better. The aim of this review is to analyze the current data on risk factors of OC concentrating on family history, obesity andoral contraceptives use. Material and method: This review was based on articles from 2010 to 2020 collected in PubMed and concerning the impact of several risk factors on developing OC. Results: The best described risk factor of OC is genetics and family history. 75% or hereditary OCs are associated to BRCA genes mutations, especially BRCA1. Other mutations increasing the risk of OC are MSH2 and MLH1 genes mutations. Diverse risk factors correlate with different histological subtypes of OC. Obesity increases the levels of estrogens, androgens and leptin, which may promote the proliferation of ovarian epithelial cells. Using oral contraceptives is related to 20% decreased risk of OC for each 5 years of use. Conclusions: BRCA1/2, MSH2 and MLH1 mutations and obesity are well-defined risk factors of ovarian cancer. The first-choice risk-reducing procedure among BRCA carriers is bilateral salpingo-oophorectomy. On the contrary, using oral contraceptives results in decreased risk of OC. Promoting knowledge about OC risk factors among women and healthcare professionals is crucial in order to reduce the number of ovarian cancer.
Polycystic ovary syndrome (PCOS) - risk factor, diagnostic and current treatment
Authors: Wojcik Justyna , Obuchowska Aleksandra , Ozga Alicja , Standyło Arkadiusz , Obuchowska Karolina , Piotrowska Paulina 
Published: October 2020

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders in women in reproductive age, defined as a combination of signs and symptoms resulting from androgen excess and ovarian dysfunction in the absence of other specific diagnoses. PCOS is often associated with an increased risk of obesity, insulin resistance, metabolic disorders and cardiovascular events. The aim of the study: The purpose of this systemic review was to collect and analyze materials about risk factors, diagnostics, and the current treatment of polycystic ovary syndrome.Material and method: Review of the literature published in 2004-2018.Description of the state of knowledge: PCOS is characterized by an excessive secretion of androgens from the ovaries and / or adrenal glands. Intrinsic ovarian factors, such as altered steroidogenesis, and factors external to the ovary, such as hyperinsulinemia, contribute to the ovarian overproduction of androgens. PCOS requires careful selection of an appropriate diagnostic method and therapeutic approach to combat hyperandrogenism, a consequence of ovarian dysfunction and related metabolic disorders. Treatment of both women at risk of PCOS and those with a confirmed diagnosis of PCOS includes education, healthy lifestyle interventions and symptomatic therapeutic interventions.Summary: PCOS is a complex disorder involving many organs and affecting many body functions. It is important to diagnose this disease as soon as possible in order to implement appropriately selected therapeutic treatment aimed at eliminating disease symptoms and reducing the systemic consequences of hyperandrogenism in patients.
Changes in management of patients with cancer during COVID-19 pandemic
Authors: Kosz Katarzyna , Zarankiewicz Natalia , Zielińska Martyna , Kuchnicka Aleksandra 
Published: October 2020

Introduction: As of March 11, 2020, COVID-19 has been declared as a global pandemic. It has spread rapidly and profoundly impact the function of health care system all around the world. As a result, management and organisation of oncology units had to be altered in order to provide security measures and safe care for patients. Purpose: The aim of this paper is to review current knowledge involving management of patients with malignancies during COVID-19 pandemic. Particular attention has been paid to changes in diagnosis, treatment and follow-up of patients with cancer. Material and methods: The review includes publications released in 2019 and 2020. The data has been collected by the use of PubMed, WHO website and other online published guidance. Results: As a lot of clinical trials has been suspended, current therapy options for patients with cancer has been also limited. Moreover, patients became fearful of becoming infected by SARS-CoV-2 and accordingly they were less likely to attend screening programmes. Additionally, as the amount of surgeries has been reduced, the need for radiotherapy service has increased. Chemotherapy has been found to be risky for patients with cancer as it may favour them to SARS-CoV-2 infection. Conclusions: Appropriate security measures need to be implemented in order to protect against SARS-CoV-2 infection but optimal health care access should be provided as well. There is a high necessity to share knowledge and experience on the impact of pandemic on patients with malignancies. However, a lot of patients are fearful of COVID-19, adverse effects of delayed diagnosis, treatment and follow-up should not be diminished.
Assessment of women's knowledge about HPV vaccination in the light of the HPV infection as a risk factor for cervical cancer
Authors: Standyło Arkadiusz , Obuchowska Aleksandra , Wójcik Justyna , Ozga Alicja 
Published: October 2020

Introduction Cervical cancer (CC) is one of the most prevalent malignancies of female reproductive tract. In Poland in 2017 CC accounted for 3.0% of all newly registered tumour cases among women, and was the eighth most common female malignancy. Persistent infection with carcinogenic human papillomavirus (HPV) is the leading risk facor. Currently, it is believed that infection with the human papillomavirus (HPV), especially its oncogenic types 16 and 18, is of fundamental importance in the development of cervical cancer. Vaccination prevents from infection with certain types of viruses, and consequently the development of cancer induced by a given type of virus. Therefore, their effi­cacy can be measured only in the long term, in a large cohort of vaccinated adolescents reaching the age charac­terized by the peak incidence of these cancers.Purpose The objective of the study was to evaluate knowledge about CC, as well as awareness of HPV and HPV vaccination among female respondents.Material and method The research was conducted on the group of 1,260 survey respondents, who filled out the Internet questionnaire. The obtained results were analysed and checked on the basis of scientific literature.Results The percentage of respondents who select human papillomavirus infection as a risk factor for the cervical cancer is 75.9%. The onset of intercourse at an early age was considered a risk factor by only 24.6%, while a large number of sexual partners by 45.4%. Women were also asked about knowledge of HPV vaccination. Only 73.8% of them heard about it and 26.2% declare unawarness of this type of vaccination.Conclusions Health promotion campaigns and educational programs are necessary in order to reduce cervical cancer burden and should be directed particularly towards those who have demonstrated low cervical cancer knowledge and low awareness regarding HPV and its vaccine.
Current prospects of urine cytology in diagnosis and follow-up urinary tract malignancies - the short review
Authors: Jarosz Piotr Michał , Oszczędłowski Paweł , Pytka Michalina , Nowaczek Justyna , Jodłowska-Jędrych Barbara 
Published: October 2020

Introduction and purpose: Cytology of urine sediment is a diagnostic tool used to screen for urinary tract lesions in two cases: surveillance of patients with a history of urothelial malignancies and patients with unexplained, new onset haematuria. Since 2015 histopathological laboratories have been able to report urine cytology according to The Paris System (TPS). Current studies suggest usefulness of urinary cytology in follow-up of urinary tract malignancies, especially urinary bladder cancer, which is the 13th most deadly throughout the world being responsible for 200 000 deaths in 2018 among neoplasms.Objective: To review currently available data on PubMed about usefulness urine cytology reporting in follow-up and diagnosis of urinary tract malignancies.A brief description of the state of knowledge: Advantages of urine cytology examination contain non-invasiveness, high specificity, lower cost than cystoscopy and enable immunohistochemistry performance as well. Implementation of The Paris System for reporting urine cytology has created an universally acceptable and globally used report system. Reporting according to TPS significantly reduced the number of cases described as atypical changes.Conclusions: Urinary cytology is used to supplement endoscopic evaluation of the urinary tract in the screening and the surveillance of urothelial carcinoma. The Paris System for reporting urinary cytology has clarified the diagnostic categories of urine sediment examination. Cystoscopy and urine cytology are the standard tools for monitoring urinary tract malignancies.
Assessment of women's knowledge about cytology as a prophylactic method in cervical cancer
Authors: Standyło Arkadiusz , Obuchowska Aleksandra , Wójcik Justyna , Ozga Alicja , Obuchowska Karolina 
Published: October 2020

Introduction Cervical cancer (CC) is currently the eight most common cancer among women and the seventh leading cause of cancer-related death in women in Poland. Early, non-invasive cervical cancer may develop over the years without clinical symptoms. Also, given the fact that early forms are treatable effectively, it's important to get preventive examinations. It is especially important in the group of women at high risk of developing CC.Purpose The aim of the study was to analyse the opinions of 1,260 women on the cytology as a prophylactic method in cervical cancer.Material and methods Women's knowledge was verified with an anonymous online questionnaire. The obtained results were analysed and checked on the basis of scientific literature.Results The vast majority of respondents (89,6%) consider Pap smear test as a screening test for CC. According to 40.4% of women, the first test should take place after sexual initiation. 17.7% believed that the examination should be done after the first menstruation. 55% of the respondents answered that Pap smear test should be performed every year. 38.4% believed that the test should be performed every 3 year. 20.3% of respondents do not know when to take the first Pap smear test and 30.1% of the respondents had never performed a pap smear.Conclusions Most women know the importance of regular cytology, but unfortunately not all women relate this knowledge to themselves. Early, regular and continuous education of women on the prevention of cervical cancer is extremely important
The application of botulinum toxin in the treatment of overactive bladder
Authors: Wojcik Justyna , Obuchowska Aleksandra , Ozga Alicja , Standyło Arkadiusz 
Published: October 2020

Introduction:Urinary incontinence is an involuntary, decision-dependent urination that leads to partial or complete emptying of the bladder. The causes include overactive bladder syndrome, which is diagnosed on the basis of clinical symptoms, such as urgency to urinate, increased frequency of voiding, nocturia caused by increased reactivity of the detrusor muscle. Treatment of this condition includes, but is not limited to, pharmacotherapy, behavioral therapy, and pelvic floor exercises. It is also possible to use an innovative method of local injection of botulinum toxin into the bladder. It inhibits the release of acetylcholine, which results in the inhibition of the contractile activity of the detrusor muscle.The aim of the study: The purpose of the systemic review was to collect and analyze material of application of botulinum toxin in the treatment of urinary incontinence caused by overactive bladder.Material and methods: The work is a review of the literature on the use of botulinum toxin in the treatment of overactive bladder, published in 2002-2020.Description of the state of knowledge:The use of the described method gives long-lasting results compared to pharmacotherapy. In addition, it eliminates the side effects caused by drugs because the administration of drugs is reduced or discontinued. The use of botulinum toxin has many more benefits than simply improving the lives of people affected by urinary incontinence. When selecting the therapy, one should also pay attention to possible side effects resulting from the use of the described drug. Summary:Intravesical administration by means of botulinum toxin cystoscopy is a modern, safe, effective and minimally invasive method of treating urinary incontinence, possible on an outpatient basis, allowing to improve the urodynamic parameters. Side effects are very rare. The botulinum toxin serotype A used in this method is the most studied serotype used for therapeutic purposes. The conducted research shows that over 90% of women reported a clinically significant improvement in sexual function after using the method.
Hepatitis A in children: evaluation of atypical manifestations
Authors: Kalyoncu Derya , Urganci Nafiye , Geylani Gulec Seda 
Published: October 2020

Background Although hepatitis A infection is known as a benign, self-limited disease without chronicity, the rate of complications increases over time.
Objective To evaluate atypical manifestations of hepatitis A infection in children.
Methods A total of 130 children with hepatitis A infection were reviewed. Subjects’ demographic and clinical characteristics, laboratory examinations, and clinical courses were evaluated retrospectively.
Results Twenty-one subjects had atypical manifestations of disease as follows: immune thrombocytopenic purpura (1 patient), pleural effusion (1), autoimmune hepatitis and hemolytic anemia (1), nephrotic syndrome (2), meningoencephalitis (2), autoimmune hepatitis (2), acalculous cholecystitis (3), relapsing hepatitis (4), and fulminant hepatitis (5). Only gender was significantly different, with males having more atypical manifestations than females (P=0.03). Mortality rate was 3% (3 patients with fulminant hepatitis and 1 with meningoencephalitis died in the intensive care unit).
Conclusion Although hepatitis A virus infection has a benign, self-limited course without chronicity, recognition of atypical cases which carry mortality risk is important.
Neuroticism Traits and Anxiety Symptoms are Exhibited in Athletes With Chronic Gastrocnemius Myofascial Pain Syndrome
Authors: San-Antolín Marta , Rodríguez-Sanz David , Becerro-de-Bengoa-Vallejo Ricardo , Losa-Iglesias Marta Elena , Martínez-Jiménez Eva María , López-López Daniel , Calvo-Lobo César 
Published: October 2020

Abstract
San-Antolín, M, Rodríguez-Sanz, D, Becerro-de-Bengoa-Vallejo, R, Losa-Iglesias, ME, Martínez-Jiménez, EM, López-López, D, and Calvo-Lobo, C. Neuroticism traits and anxiety symptoms are exhibited in athletes with chronic gastrocnemius myofascial pain syndrome. J Strength Cond Res 34(12): 3377–3385, 2020—Common psychological factors, such as anxiety or neurotic personality traits, seem to be associated with pain suffered by athletes. Gastrocnemius muscles present a high prevalence for injury in athletes. These muscles are a region in which myofascial pain syndrome (MPS) frequently develops. Myofascial pain syndrome is characterized by the presence of active myofascial trigger points (MTrPs). This study compared different personality and anxiety symptoms between athletes with and without active MTrPs in the gastrocnemius. A case-control study was conducted in an outpatient clinic. Athletes who performed moderate or vigorous physical activity according to the International Physical Activity Questionnaire were included. Fifty paired-matched athletes with and without active MTrPs in their gastrocnemius muscles (n = 25 in each group) were recruited. Different personality traits (neuroticism, extraversion, psychoticism, and sincerity) and anxiety (state and trait) were evaluated by the Eysenck Personality Questionnaire and State-Trait Anxiety Inventory, respectively. Statistically significant differences (p < 0.01) with an effect size from moderate to large (d = 0.75–1.29) were found for greater neuroticism and sincerity traits in addition to state and trait anxiety in athletes with gastrocnemius MPS compared with healthy controls. In conclusion, athletes with gastrocnemius active MTrPs exhibited higher neuroticism and anxiety symptoms compared with healthy athletes. Mental health may play a key role in athletes with myofascial pain, and future studies should be performed to determine whether neuroticism-related and anxiety-related psychological care could be a key intervention in athletes with gastrocnemius active MTrPs to improve athletic performance and rehabilitation or prevent injuries.