bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diversity minimization through part combination – a Portuguese railway infrastructure case study
Authors: Rechena Diogo , Sousa Luís , Infante Virgínia , Henriques Elsa 
Published: February 2020

AbstractWith increasing market needs for product and service variety, companies struggle to provide diversity in cost-effective ways. Through standardization of components with a low perceived added value, companies can take advantage of economies of scale while maintaining product diversity. Railway infrastructure managers face similar challenges of providing economically sustainable services while dealing with the costs of maintaining the system diversity. Typically, unintended design diversity stems from design practices in which existing solutions are not reused for new problems and new solutions are rarely planned considering the dynamics of requirement changes. In this paper we provide a methodology to assess how to standardize different designs to minimize design diversity and to assess design divergence in a product family. The developed methodology is able to take into account any set of standardization compatibility constraints that the user can define. The methodology was applied in the context of a small-scale railway infrastructure manager using a dataset of 223 unique designs of functionally similar components from its electrification system. Depending on the activated compatibility constraints, results indicate that over 60% of components can be reduced to a set of 86 unique designs.
Statistical tolerance analysis applied on overconstrained mechanisms with form deviations
Authors: Gouyou Doriane , Teissandier Denis , Delos Vincent , Ledoux Yann 
Published: February 2020

AbstractOne method for modeling geometric variations in hyperstatic (i.e. overconstrained) systems is to use sets of constraints. Different models have been developed in this way, e.g. domains, T-maps, and polytopes. In general, if the intersection of the contact constraints between two parts potentially in contact is nonempty, the parts can be assembled without interference, and their relative positions determined. In this study, the polytope method is used with a statistical approach to define the behavior of an assembly. In the first part, geometric variations including form deviations of individual parts are defined. The relations between these variations resulting from the architecture of a mechanism are then defined. In the second part, contact constraints are introduced and the general method to conform the constraints into double description polytopes is presented. The general process to simulate the compliance of the mechanism with respect to functional conditions is described. A failure rate is obtained for a simulated population of manufactured parts using the Monte Carlo method. In the third part, an application to a flange is described, an example from an industrial case study. We show how to take advantage of double description of polytopes when simulating the assembly and the misalignment of the two parts that make up the flange. Finally, we present our conclusions and prospects for future studies.
Cutting Through the Fog: Financial Literacy and Financial Investment Choices
Authors: Nieddu Marco , Pandolfi Lorenzo 
Published: February 2020

Abstract
This paper examines the impact of financial literacy on the individual propensity to invest in financial assets. In a laboratory experiment with a two-by-two design, we study how the certainty equivalent of a risky lottery changes when varying the lottery framing and the participants’ financial literacy level. We find that presenting the lottery as a financial asset—whose payoffs need to be computed from a given return rate—rather than as a simple coin toss reduces the average value participants assign to the lottery by approximately 20% and lowers their understanding of the lottery’s structure. Enhancing financial literacy by explaining the basic financial concepts involved in the description of the financial-asset lottery, offsets the negative effects of the financial framing: it improves respondents’ understanding of the lottery and increases the certainty equivalent. Our results—which can be rationalized by ambiguity aversion—shed new light on the linkages between financial literacy and financial investment behavior. Additionally, they highlight the importance of promoting financial education to stimulate households’ financial market participation.
Oral Step-Down Therapy With Levofloxacin for Febrile Neutropenia in Children With Cancer
Authors: Olson Jared , Mehra Sonia , Hersh Adam L , Thorell Emily A , Stoddard Gregory J , Maese Luke , Barnette Phillip E , Lemons Richard S , Pavia Andrew T , Knackstedt Elizabeth D 
Published: February 2020

Abstract

Background
Although febrile neutropenia (FN) is a frequent complication in children with cancer receiving chemotherapy, there remains significant variability in selection of route (intravenous [IV] vs oral) and length of therapy. We implemented a guideline with a goal to change practice from using IV antibiotics after hospital discharge to the use of step-down oral therapy with levofloxacin for most children with FN until absolute neutrophil count &gt; 500. The objectives of this study were to determine the impact of this guideline on home IV antibiotic use, and to evaluate the safety of implementation of this guideline.

Methods
We performed a quasi-experimental, pre–post study of discharge FN treatment at a stand-alone children’s hospital in patients without bacteremia discharged between January 2013 and October 2018. In January 2015, a multidisciplinary team created a guideline to switch most children with FN to oral levofloxacin, which was formally implemented as of September 2017. Discharges during the postintervention period (after September 2017) were compared to discharges in the preintervention period (between January 2013 and December 2014).

Results
In adjusted multivariable regression analyses, the postimplementation period was associated with a decrease in home IV antibiotics (adjusted risk ratio [aRR], 0.07 [95% confidence interval {CI}, .03–.13]) and fewer IV antibiotic initiations within 24 hours of a new healthcare encounter up to 7 days after discharge (aRR, 0.39 [95% CI, .17–.93]) compared to the preintervention time period.

Conclusions
Step-down oral levofloxacin for children with FN who are afebrile with an ANC ≤ 500 at discharge is feasible and resulted in similar clinical outcomes compared to home IV antibiotics.
Inferring the role of pit membranes in solute transport from solute exclusion studies in living conifer stems
Authors: Yang Dongmei , Wei Kailu , Li Junhui , Peng Guoquan , Tyree Melvin T 
Published: February 2020

Abstract
The functional role of pits between living and dead cells has been inferred from anatomical studies but amassing physiological evidence has been challenging. Centrifugation methods were used to strip water from xylem conduits, permitting a more quantitative gravimetric determination of the water and solid contents of cell walls than is possible by more traditional methods. Quantitative anatomical evidence was used to evaluate the water volume in xylem conduits and the water content of living cells. Quantitative perfusion of stems with polyethylene glycol of different molecular weight was used to determine the solute-free space. We measured the portioning of water and solute-free space among anatomical components in stems and demonstrated that lignin impeded the free movement of solutes with molecular weight &gt;300. Hence, movement of large solutes from living cells to xylem conduits is necessarily confined to pit structures that permit transmembrane solute transport via primary walls without lignin. The functional role of pits was additionally indicated by combining data in this paper with previous studies of unusual osmotic relationships in woody species that lack pits between dead wood fibers and vessels. The absence of pits, combined with the evidence of exclusion of solutes of molecular weight &gt;300, explains the unexpected osmotic properties.
The SUrvey for Pulsars and Extragalactic Radio Bursts – IV. Discovery and polarimetry of a 12.1-s radio pulsar
Authors: Morello V , Keane E F , Enoto T , Guillot S , Ho W C G , Jameson A , Kramer M , Stappers B W , Bailes M , Barr E D , Bhandari S , Caleb M , Flynn C M L , Jankowski F , Johnston S , van Straten W , Arzoumanian Z , Bogdanov S , Gendreau K C , Malacaria C , Ray P S , Remillard R A 
Published: February 2020

ABSTRACT
We report the discovery of PSR J2251−3711, a radio pulsar with a spin period of 12.1 s, the second longest currently known. Its timing parameters imply a characteristic age of 15 Myr, a surface magnetic field of 1.3 × 1013 G, and a spin-down luminosity of 2.9 × 1029 erg s−1. Its dispersion measure of 12.12(1) pc cm−3 leads to distance estimates of 0.5 and 1.3 kpc according to the NE2001 and YMW16 Galactic free electron density models, respectively. Some of its single pulses show an uninterrupted 180-deg sweep of the phase-resolved polarization position angle, with an S-shape reminiscent of the rotating vector model prediction. However, the fact that this sweep occurs at different phases from one pulse to another is remarkable and without straightforward explanation. Although PSR J2251−3711 lies in the region of the $P-\dot{P}$ parameter space occupied by the X-ray isolated neutron stars (XINS), there is no evidence for an X-ray counterpart in our Swift XRT observation; this places a 99 per cent-confidence upper bound on its unabsorbed bolometric thermal luminosity of $1.1 \times 10^{31}~(d / 1~\mathrm{kpc})^2~\mathrm{erg\, s}^{-1}$ for an assumed temperature of 85 eV, where d is the distance to the pulsar. Further observations are needed to determine whether it is a rotation-powered pulsar with a true age of at least several Myr, or a much younger object such as an XINS or a recently cooled magnetar. Extreme specimens like PSR J2251−3711 help bridge populations in the so-called neutron star zoo in an attempt to understand their origins and evolution.
The infrared view of dust and molecules around V4334 Sgr (Sakurai’s object): a 20-yr retrospective
Authors: Evans A , Gehrz R D , Woodward C E , Banerjee D P K , Geballe T R , Clayton G C , Sarre P J , Starrfield S , Hinkle K , Joyce R R , Lykou Foteini , Helton L A , Eyres S P S , Worters H , Montiel E J , Liimets T , Zijlstra A , Richter M , Krautter J 
Published: February 2020

ABSTRACT
We present an analysis of the evolution of circumstellar dust and molecules in the environment of the very late thermal pulse object V4334 Sgr (Sakurai’s object) over an ∼20-yr period, drawing on ground-, airborne-, and space-based infrared photometry and spectroscopy. The dust emission, which started in 1997, resembles a blackbody that cooled from ∼1200 K in 1998 August to ∼180 K in 2016 July. The dust mass, assuming amorphous carbon, was ∼5 × 10−10 M⊙ in 1998 August, and we estimate that the total dust mass was ∼2 × 10−5 M⊙ by ∼2016. The appearance of a near-infrared excess in 2008 suggests that a new episode of (or renewed) mass-loss began then. We infer lower limits on the bolometric luminosity of the embedded star from that of the dust shell, which rose to ∼16 000 L⊙ before declining to ∼3000 L⊙. There is evidence for weak 6–7 μm absorption, which we attribute to hydrogenated amorphous carbon formed in material ejected by Sakurai’s object during a mass ejection phase that preceded the 1997 event. We detect small hydrocarbon and other molecules in the spectra, and trace the column densities in hydrogen cyanide (HCN) and acetylene (C2H2). We use the former to determine the 12C/13C ratio to be 6.4 ± 0.7, 14 times smaller than the Solar system value.
Cis- and Trans-Regulatory Variations in the Domestication of the Chili Pepper Fruit
Authors: Díaz-Valenzuela Erik , Sawers Ruairidh H , Cibrián-Jaramillo Angélica 
Published: February 2020

AbstractThe process of domestication requires the rapid transformation of the wild morphology into the cultivated forms that humans select for. This process often takes place through changes in the regulation of genes, yet, there is no definite pattern on the role of cis- and trans-acting regulatory variations in the domestication of the fruit among crops. Using allele-specific expression and network analyses, we characterized the regulatory patterns and the inheritance of gene expression in wild and cultivated accessions of chili pepper, a crop with remarkable fruit morphological variation. We propose that gene expression differences associated to the cultivated form are best explained by cis-regulatory hubs acting through trans-regulatory cascades. We show that in cultivated chili, the expression of genes associated with fruit morphology is partially recessive with respect to those in the wild relative, consistent with the hybrid fruit phenotype. Decreased expression of fruit maturation and growth genes in cultivated chili suggest that selection for loss-of-function took place in its domestication. Trans-regulatory changes underlie the majority of the genes showing regulatory divergence and had larger effect sizes on gene expression than cis-regulatory variants. Network analysis of selected cis-regulated genes, including ARP9 and MED25, indicated their interaction with many transcription factors involved in organ growth and fruit ripening. Differentially expressed genes linked to cis-regulatory variants and their interactions with downstream trans-acting genes have the potential to drive the morphological differences observed between wild and cultivated fruits and provide an attractive mechanism of morphological transformation during the domestication of the chili pepper.
High-grade gliomas in adolescents and young adults highlight histomolecular differences from their adult and pediatric counterparts
Authors: Roux Alexandre , Pallud Johan , Saffroy Raphaël , Edjlali-Goujon Myriam , Debily Marie-Anne , Boddaert Nathalie , Sanson Marc , Puget Stéphanie , Knafo Steven , Adam Clovis , Faillot Thierry , Cazals-Hatem Dominique , Mandonnet Emmanuel , Polivka Marc , Dorfmüller Georges , Dauta Aurélie , Desplanques Mathilde , Gareton Albane , Pages Mélanie , Tauziede-Espariat Arnault , Grill Jacques , Bourdeaut Franck , Doz François , Dhermain Frédéric , Mokhtari Karima , Chretien Fabrice , Figarella-Branger Dominique , Varlet Pascale 
Published: February 2020

Abstract

Background
Considering that pediatric high-grade gliomas (HGGs) are biologically distinct from their adult counterparts, the objective of this study was to define the landscape of HGGs in adolescents and young adults (AYAs).

Methods
We performed a multicentric retrospective study of 112 AYAs from adult and pediatric Ile-de-France neurosurgical units, treated between 1998 and 2013 to analyze their clinicoradiological and histomolecular profiles. The inclusion criteria were age between 15 and 25 years, histopathological HGG diagnosis, available clinical data, and preoperative and follow-up MRI. MRI and tumoral samples were centrally reviewed. Immunohistochemistry and complementary molecular techniques such as targeted/next-generation sequencing, whole exome sequencing, and DNA-methylation analyses were performed to achieve an integrated diagnosis according to the 2016 World Health Organization (WHO) classification.

Results
Based on 80 documented AYA patients, HGGs constitute heterogeneous clinicopathological and molecular groups, with a predominant representation of pediatric subtypes (histone H3-mutants, 40%) but also adult subtypes (isocitrate dehydrogenase [IDH] mutants, 28%) characterized by the rarity of oligodendrogliomas, IDH mutants, and 1p/19q codeletion and the relative high frequency of “rare adult IDH mutations” (20%). H3G34-mutants (14%) represent the most specific subgroup in AYAs. In the H3K27-mutant subgroup, non-brainstem diffuse midline gliomas are more frequent (66.7%) than diffuse intrinsic pontine gliomas (23.8%), contrary to what is observed in children. We found that WHO grade has no prognostic value, but molecular subgrouping has major prognostic importance.

Conclusions
HGGs in AYAs could benefit from a specific classification, driven by molecular subtyping rather than age group. Collaborative efforts are needed from pediatric and adult neuro-oncology teams to improve the management of HGGs in AYAs.
Transcallosal Interforniceal Approach for a Large Choroid Plexus Tumor in a 4-Month-Old Boy: 2-Dimensional Operative Video
Authors: Ravindra Vijay M , Aldave Guillermo 
Published: February 2020

Abstract
Tumors in the third ventricle constitute a challenge for the neurosurgeon, regardless of the chosen approach. The additional risk of severe blood loss in the pediatric population, specially for choroid plexus tumors, which are the most common ventricular tumors in children, adds a significant challenge in these cases. Therefore, a careful selection of the approach in addition to surgical technique is crucial for a favorable outcome.
In this video, we discuss the approach selected for the treatment of a large choroid plexus tumor in a 4-mo-old male and highlight the surgical technique chosen for this case, a transcallosal interforniceal approach.
1
Appropriate consent for the video authorization and the procedure was obtained from the parent of the patient. Images in video from Rhoton AL Jr, The Cerebrum, Neurosurgery, 2007, 61, suppl_1, SHC-37-SHC-119, by permission of the Congress of Neurological Surgeons.
Maternal and neonatal outcomes associated with biologic exposure before and during pregnancy in women with inflammatory systemic diseases: a systematic review and meta-analysis of observational studies
Authors: Tsao Nicole W , Rebic Nevena , Lynd Larry D , De Vera Mary A 
Published: February 2020

Abstract

Objective
To determine the association between exposure to biologics in pregnant women with inflammatory systemic diseases and maternal and neonatal outcomes through a meta-analysis of findings from studies identified in a systematic review.

Methods
We conducted a systematic review of Medline, Embase, and Cochrane Database of Systematic Reviews to identify observational studies assessing the perinatal impacts of biologic in women with inflammatory systemic disease. Findings were meta-analysed across included studies with random-effects models. Crude risk estimates and, where possible, adjusted risk estimates were pooled to determine the impact on results when confounding is addressed.

Results
Overall, 24 studies were included in the meta-analysis. Meta-analyses of crude risk estimates resulted in pooled odds ratios (OR) for the association of biologic use during pregnancy and the following respective outcomes: congenital anomalies (1.30, 95% CI: 1.02, 1.67), preterm birth (OR 1.61, 95% CI: 1.37, 1.89), and low birth weight (OR 1.68, 95% CI: 1.21, 2.31). However, in pooled analyses of adjusted risk estimates we observed that the association between biologics use during pregnancy in disease-matched exposed and unexposed pregnant women was no longer statistically significant for congenital anomalies (adjusted OR 1.18, 95% CI: 0.88, 1.57).

Conclusion
Pooled results from studies reporting adjusted risk estimates showed no increased risk of congenital anomalies associated with biologics use, suggesting that increased rates of adverse outcomes may be due to disease activity itself or other confounders.
Phylogenetic analysis of the subfamily Prodidominae (Arachnida: Araneae: Gnaphosidae)
Authors: Rodrigues Bruno V B , Rheims Cristina A 
Published: February 2020

AbstractProdidominae was recently re-established as a subfamily of Gnaphosidae, comprising 316 species placed in 33 genera. In this study, we conduct a cladistic analysis including 59 species of Prodidominae and 32 outgroup species. The matrix is composed of 291 morphological characters and the data are analysed under the parsimony criterion, using differing weighting regimes. Prodidominae is not recovered as monophyletic, because Anagrina did not arise within the subfamily. Cryptotoerithus, Molycria, Myandra, Nomindra, Wesmaldra and Wydundra arise to form a clade. Thus, we re-establish Molycriinae as a distinct subfamily in Gnaphosidae, sister to Prodidominae. We redefine the limits of Prodidominae to include the genera Austrodomus, Brasilomma, Caudalia, Chileomma, Chileuma, Chilongius, Eleleis, Indiani, Katumbea, Lygromma, Lygrommatoides, Moreno, Namundra, Neozimiris, Nopyllus, Paracymbiomma, Plutonodomus, Prodidomus, Purcelliana, Theuma, Theumella, Tivodrassus, Tricongius, Zimirina and Zimiris. Species of these genera share the presence of anterior lateral spinnerets with pyriform gland spigots associated with patches of long setae and the presence of a large protrusion between coxae IV with erect setae and unsclerotized margins. In addition, we propose three new synonymies: Oltacloea as a junior synonym of Tricongius, and Prodida as junior synonym of Prodidomus. Lygromma ybyguara is transferred to Tricongius.
Muscone reduced the hypnotic and analgesic effect of ketamine in mice
Authors: Liu Chuiliang , Huang Zeqi , Li Zhipeng , Li Junhua , Li Yujuan 
Published: February 2020

Background:
The aim of this study was to determine the effects of different concentrations of muscone on the ketamine requirement for hypnosis and analgesia and possible mechanism in mice.

Methods:
In the hypnotic response experiment, muscone (0.5, 1.0, 2.0, 4.0, and 8.0 mg/kg) was administered 15 minutes before ketamine by intraperitoneal injection. The hypnotic response was evaluated by loss of righting reflex (LORR). In the analgesia experiment, muscone (0.5, 1.0, 2.0, and 4.0 mg/kg) was administered 15 minutes before 50 mg/kg ketamine injection. Pain threshold was assessed by measuring the tail-flick latency induced by heat radiation. Twenty minutes after ketamine injection, the mRNA expression of N-methyl-d-aspartate receptors (NR) subunits, γ-aminobutyric acid (GABA) receptors subunits, opioid receptors subunits, and some Na+ and Ca2+ channels were detected by qPCR in the hippocampus of mice.

Results:
The 50% effective dose (ED50) with 95% confidence interval of ketamine-induced LORR was 49.2 (43.4-56.4) mg/kg. About 4.0 or 8.0 mg/kg muscone increased ED50 of ketamine-induced hypnosis, which was 82.7 (70.0-98.4) mg/kg or 72.0 (65.4-85.7) mg/kg, respectively. In the analgesic experiment, ketamine alone caused an obvious analgesic effect, whereas different dose of muscone decreased pain threshold in the presence of ketamine; 4.0 mg/kg muscone up-regulated the mRNA expression of NR1 and inhibited ketamine-induced increase of δ-opioid receptor mRNA level. Muscone also inhibited Cav2.1 mRNA expression in the presence of ketamine.

Conclusion:
Muscone reduced the hypnotic and analgesic effect of ketamine in dose-independent manner in mice, which may be related to the changes of NR1 and δ-opioid receptor.