bluuebunny/crossref_metadata_2025_split huggingface dataset:
A pilot study of a neuroscience-based, harm minimisation programme in schools and youth centres in Australia
Authors: Debenham Jennifer , Birrell Louise , Champion Katrina , Askovic Mina , Newton Nicola 
Published: February 2020

ObjectivesThe primary aim is to evaluate the feasibility of a newly developed, neuroscience-based, alcohol and other drug (AOD) use prevention programme, ‘The Illicit Project’, in Australian older adolescents. The secondary aim is to investigate the impact of the programme on students’ drug literacy levels (a combination of knowledge, attitudes and skills).DesignA pilot study examining the feasibility of The Illicit Project in Australian schools was conducted.ParticipantsStudents aged 15–19 years from two secondary schools and a youth centre and 11 teachers and health professionals from various organisations in Sydney were recruited.InterventionThe intervention consisted of three 90 min workshops delivered by trained facilitators within a month.Primary and secondary measuresStudents completed a drug literacy questionnaire before and after intervention. All participants (students, teachers and health professionals) completed an evaluation questionnaire postprogramme delivery. A paired-sample t-test and descriptive analytics were performed.ResultsStudents (n=169) demonstrated a significant increase in drug literacy levels from preintervention to postintervention (t(169) = −13.22, p<0.0001). Of students evaluating the programme (n=252), over threequarters agreed that The Illicit Project was good or very good (76%), that the neuroscience content was interesting (76%) and relevant (81%), and that they plan to apply the concepts learnt to their own lives (80%). In addition, all teachers and health professionals (n=11) agreed that the programme was feasible and valid for schools and perceived the programme to be effective in reducing the harms and use of AOD.ConclusionsThere is evidence to suggest that The Illicit Project is credible and feasible in the school environment and there are preliminary data to suggest it may help to improve drug literacy levels in young people. A large-scale evaluation trial of the intervention will be conducted to determine the programme’s effectiveness in minimising the harms of AOD in older adolescents.
Outcome of endovascular recanalization for intracranial in-stent restenosis
Authors: Kang Kaijiang , Gao Feng , Mo Dapeng , Yang Ming , Liu Yifan , Yang Bo , Chen Xing , Gu Weibin , Ma Guofeng , Zhao Xingquan , Miao Zhong-Rong , Ma Ning 
Published: February 2020

Background and purposeIn-stent restenosis (ISR) is one of the long-term adverse outcomes of endovascular angioplasty and stenting for symptomatic intracranial arterial stenosis. In this study, we try to evaluate the safety and efficacy of endovascular treatment for intracranial ISR.MethodsWe retrospectively collected patients with intracranial ISR who underwent endovascular treatment from June 2012 to August 2019 at a high-volume stroke center. Successful recanalization was defined as ≤30% residual stenosis. Stroke, myocardial infarction, and death after stenting within 30 days were used to evaluate periprocedural safety. Recurrent stroke in the territory of the culprit vessel and re-ISR in patients with clinical and vascular imaging follow-up data were used to evaluate the long-term outcome.Results32 patients (59.6±7.2 years old) with ISR were recruited, including 22 patients (68.8%) treated with balloon dilatation, 8 patients (25%) with stenting, and 2 patients (6.3%) with failed procedures. Successful recanalization was achieved in 71.9% (23/32) of patients. There was no stroke, myocardial infarction or death within 30 days after the procedure. Recurrent stroke was found in 10.7% (3/28) of the patients, and re-ISR was found in 42.1% (8/19) of the patients. The re-ISR rate was lower in patients with stenting than in those with balloon dilatation (0% vs 57.1%, p=0.090), and in patients with successful recanalization than in those with unsuccessful recanalization (33.3% vs 75.0%, p=0.352), but with no statistically significant difference.ConclusionsThe periprocedural safety of endovascular treatment for intracranial ISR may be acceptable, but the long-term rates of recurrent stroke and re-ISR remain at high levels.
Temporal trends in respirable dust and respirable quartz concentrations within the European industrial minerals sector over a 15-year period (2002–2016)
Authors: Zilaout Hicham , Houba Remko , Kromhout Hans 
Published: February 2020

ObjectivesSince 2000 the European Industrial Minerals Association’s Dust Monitoring Programme (IMA-DMP) has systematically collected respirable dust and respirable quartz measurements from 35 companies producing industrial minerals. The IMA-DMP initiative allowed for estimating overall temporal trends in exposure concentrations for the years 2002–2016 and for presenting these trends by type of mineral produced, by jobs performed and by time of enrolment into the DMP.MethodsApproximately 32 000 personal exposure measurements were collected during 29 sampling campaigns during a 15-year period (2002–2016). Temporal trends in respirable dust and respirable quartz concentrations were studied by using linear mixed effects models.ResultsConcentrations varied widely (up to three to four orders of magnitude). However, overall decreases in exposure levels were shown for the European minerals industry over the 15-year period. Statistically significant overall downward temporal trends of −9.0% and −3.9% per year were observed for respirable dust and respirable quartz, respectively. When analyses were stratified by time period, no downward trends (and even slight increasing concentrations) were observed between 2008 and 2012, most likely attributable to the recent global economic crisis. After this time period, downward trends became visible again.ConclusionsConsistent and statistically significant downward trends were found for both exposure to respirable dust and respirable quartz. These downward trends became less or even reversed during the years of the global economic crisis. To our knowledge, this is the first time that analyses of long-term temporal trends point at an effect of a global economic crisis on personal exposure concentrations of workers from sites across Europe.
Nucleon’s energy–momentum tensor form factors in light-cone QCD
Authors: Azizi K. , Özdem U. 
Published: February 2020

AbstractWe use the energy–momentum tensor (EMT) current to compute the EMT form factors of the nucleon in the framework of the light cone QCD sum rule formalism. In the calculations, we employ the most general form of the nucleon’s interpolating field and use the distribution amplitudes (DAs) of the nucleon with two sets of the numerical values of the main input parameters entering the expressions of the DAs. The directly obtained results from the sum rules for the form factors are reliable at $$ Q^2\ge 1$$Q2≥1 GeV$$^2 $$2: to extrapolate the results to include the zero momentum transfer squared with the aim of estimation of the related static physical quantities, we use some fit functions for the form factors. The numerical computations show that the energy–momentum tensor form factors of the nucleon can be well fitted to the multipole fit form. We compare the results obtained for the form factors at $$ Q^2=0 $$Q2=0 with the existing theoretical predictions as well as experimental data on the gravitational form factor d$$_1^q(0)$$1q(0). For the form factors M$$_2^q (0)$$2q(0) and J$$^q(0)$$q(0) a consistency among the theoretical predictions is seen within the errors: our results are nicely consistent with the Lattice QCD and chiral perturbation theory predictions. However, there are large discrepancies among the theoretical predictions on d$$_1^q(0)$$1q(0). Nevertheless, our prediction is in accord with the JLab data as well as with the results of the Lattice QCD, chiral perturbation theory and KM15-fit. Our fit functions well define most of the JLab data in the interval $$ Q^2\in [0,0.4]$$Q2∈[0,0.4] GeV$$^2 $$2, while the Lattice results suffer from large uncertainties in this region. As a by-product, some mechanical properties of the nucleon like the pressure and energy density at the center of nucleon as well as its mechanical radius are also calculated and their results are compared with other existing theoretical predictions.
The shocklet transform: a decomposition method for the identification of local, mechanism-driven dynamics in sociotechnical time series
Authors: Dewhurst David Rushing , Alshaabi Thayer , Kiley Dilan , Arnold Michael V. , Minot Joshua R. , Danforth Christopher M. , Dodds Peter Sheridan 
Published: February 2020

AbstractWe introduce a qualitative, shape-based, timescale-independent time-domain transform used to extract local dynamics from sociotechnical time series—termed the Discrete Shocklet Transform (DST)—and an associated similarity search routine, the Shocklet Transform And Ranking (STAR) algorithm, that indicates time windows during which panels of time series display qualitatively-similar anomalous behavior. After distinguishing our algorithms from other methods used in anomaly detection and time series similarity search, such as the matrix profile, seasonal-hybrid ESD, and discrete wavelet transform-based procedures, we demonstrate the DST’s ability to identify mechanism-driven dynamics at a wide range of timescales and its relative insensitivity to functional parameterization. As an application, we analyze a sociotechnical data source (usage frequencies for a subset of words on Twitter) and highlight our algorithms’ utility by using them to extract both a typology of mechanistic local dynamics and a data-driven narrative of socially-important events as perceived by English-language Twitter.
Gut microbiome of a porcine model of metabolic syndrome and HF-pEF
Authors: O’Donovan Aoife N. , Herisson Florence M. , Fouhy Fiona , Ryan Paul M. , Whelan Derek , Johnson Crystal N. , Cluzel Gaston , Ross R. Paul , Stanton Catherine , Caplice Noel M. 
Published: February 2020

Metabolic syndrome (MetS) is a composite of cardiometabolic risk factors, including obesity, dyslipidemia, hypertension, and insulin resistance, with a range of secondary sequelae such as nonalcoholic fatty liver disease and diastolic heart failure. This syndrome has been identified as one of the greatest global health challenges of the 21st century. Herein, we examine whether a porcine model of diet- and mineralocorticoid-induced MetS closely mimics the cardiovascular, metabolic, gut microbiota, and functional metataxonomic phenotype observed in human studies. Landrace pigs with deoxycorticosterone acetate-induced hypertension fed a diet high in fat, salt, and sugar over 12 wk were assessed for hyperlipidemia, hyperinsulinemia, and immunohistologic, echocardiographic, and hemodynamic parameters, as well as assessed for microbiome phenotype and function through 16S rRNA metataxonomic and metabolomic analysis, respectively. All MetS animals developed obesity, hyperlipidemia, insulin resistance, hypertension, fatty liver, structural cardiovascular changes including left ventricular hypertrophy and left atrial enlargement, and increased circulating saturated fatty acid levels, all in keeping with the human phenotype. A reduction in α-diversity and specific microbiota changes at phylum, family, and genus levels were also observed in this model. Specifically, this porcine model of MetS displayed increased abundances of proinflammatory bacteria coupled with increased circulating tumor necrosis factor-α and increased secondary bile acid-producing bacteria, which substantially impacted fibroblast growth factor-19 expression. Finally, a significant decrease in enteroprotective bacteria and a reduction in short-chain fatty acid-producing bacteria were also noted. Together, these data suggest that diet and mineralocorticoid-mediated development of biochemical and cardiovascular stigmata of metabolic syndrome in pigs leads to temporal gut microbiome changes that mimic key gut microbial population signatures in human cardiometabolic disease. NEW & NOTEWORTHY This study extends a prior porcine model of cardiometabolic syndrome to include systemic inflammation, fatty liver, and insulin sensitivity. Gut microbiome changes during evolution of porcine cardiometabolic disease recapitulate those in human subjects with alterations in gut taxa associated with proinflammatory bacteria, bile acid, and fatty acid pathways. This clinical scale model may facilitate design of future interventional trials to test causal relationships between gut dysbiosis and cardiometabolic syndrome at a systemic and organ level.
Rindopepimut with Bevacizumab for Patients with Relapsed EGFRvIII-Expressing Glioblastoma (ReACT): Results of a Double-Blind Randomized Phase II Trial
Authors: Reardon David A. , Desjardins Annick , Vredenburgh James J. , O'Rourke Donald M. , Tran David D. , Fink Karen L. , Nabors Louis B. , Li Gordon , Bota Daniela A. , Lukas Rimas V. , Ashby Lynn S. , Duic J. Paul , Mrugala Maciej M. , Cruickshank Scott , Vitale Laura , He Yi , Green Jennifer A. , Yellin Michael J. , Turner Christopher D. , Keler Tibor , Davis Thomas A. , Sampson John H. 
Published: February 2020

Abstract

Purpose:
Rindopepimut is a vaccine targeting the tumor-specific EGF driver mutation, EGFRvIII. The ReACT study investigated whether the addition of rindopepimut to standard bevacizumab improved outcome for patients with relapsed, EGFRvIII-positive glioblastoma.

Patients and Methods:
In this double-blind, randomized, phase II study (NCT01498328) conducted at 26 hospitals in the United States, bevacizumab-naïve patients with recurrent EGFRvIII-positive glioblastoma were randomized to receive rindopepimut or a control injection of keyhole limpet hemocyanin, each concurrent with bevacizumab. The primary endpoint was 6-month progression-free survival (PFS6) by central review with a one-sided significance of 0.2.

Results:
Between May 2012 and 2014, 73 patients were randomized (36 rindopepimut, 37 control). Rindopepimut toxicity included transient, low-grade local reactions. As primary endpoint, PFS6 was 28% (10/36) for rindopepimut compared with 16% (6/37) for control (P = 0.12, one-sided). Secondary and exploratory endpoints also favored the rindopepimut group including a statistically significant survival advantage [HR, 0.53; 95% confidence interval (CI), 0.32–0.88; two-sided log-rank P = 0.01], a higher ORR [30% (9/30) vs. 18% (6/34; P = 0.38)], median duration of response [7.8 months (95% CI, 3.5–22.2) vs. 5.6 (95% CI, 3.7–7.4)], and ability to discontinue steroids for ≥6 months [33% (6/18) vs. 0% (0/19)]. Eighty percent of rindopepimut-treated patients achieved robust anti-EGFRvIII titers (≥1:12,800), which were associated with prolonged survival (HR = 0.17; 95% CI, 0.07–0.45; P &lt; 0.0001).

Conclusions:
Our randomized trial supports the potential for targeted immunotherapy among patients with GBM, but the therapeutic benefit requires validation due to the small sample size and potential heterogeneity of bevacizumab response among recurrent patients with GBM.
See related commentary by Wick and Wagener, p. 1535
Routine Plasma-Based Genotyping to Comprehensively Detect Germline, Somatic, and ReversionBRCAMutations among Patients with Advanced Solid Tumors
Authors: Vidula Neelima , Rich Thereasa A. , Sartor Oliver , Yen Jennifer , Hardin Aaron , Nance Tracy , Lilly Michael B. , Nezami Mohammad Amin , Patel Sandip P. , Carneiro Benedito A. , Fan Alice C. , Brufsky Adam M. , Parker Barbara A. , Bridges Benjamin B. , Agarwal Neeraj , Maughan Benjamin L. , Raymond Victoria M. , Fairclough Stephen R. , Lanman Richard B. , Bardia Aditya , Cristofanilli Massimo 
Published: February 2020

AbstractPurpose:PARP inhibitors (PARPi) are efficacious in multiple cancers harboring germline (and possibly somatic) BRCA1/2 mutations. Acquired reversions can restore BRCA1/2 function, causing resistance to PARPi and/or platinum-based chemotherapy. The optimal method of identifying patients with germline, somatic, and/or reversion mutations in BRCA1/2 has not been established. Next-generation sequencing (NGS) of cell-free DNA (cfDNA) provides a platform to identify these three types of BRCA1/2 mutations.Experimental Design:Patients with advanced breast, ovarian, prostate, or pancreatic cancer were tested using a clinically validated 73-gene cfDNA assay that evaluates single-nucleotide variants and insertion–deletion mutations (indels) in BRCA1/2, and distinguishes somatic/reversion from germline mutations with high accuracy.Results:Among 828 patients, one or more deleterious BRCA1/2 mutations were detected in 60 (7.2%) patients, including germline (n = 42) and somatic (n = 18) mutations. Common coexisting mutations included TP53 (61.6%), MYC (30%), PIK3CA (26.6%), BRAF (15%), and ESR1 (11.5%). Polyclonal reversion mutations (median, 5) were detected in 9 of 42 (21.4%) germline BRCA1/2-mutant patients, the majority (77.7%) of whom had prior PARPi exposure (median duration, 10 months). Serial cfDNA demonstrated emergence of reversion BRCA mutations under therapeutic pressure from initial PARPi exposure, which contributed to subsequent resistance to PARPi and platinum therapy.Conclusions:cfDNA NGS identified high rates of therapeutically relevant mutations without foreknowledge of germline or tissue-based testing results, including deleterious somatic BRCA1/2 mutations missed by germline testing and reversion mutations that can have important treatment implications. Further research is needed to confirm clinical utility of these findings to guide precision medicine approaches for patients with advanced malignancies.
The Relevance of Typology for Pattern Replication
Authors: Meyer Robin 
Published: February 2020

Structuralists and generativists have insisted for a long time that the elements and structures one language could borrow from another are constrained by typological compatibility, naturalness, and other factors (cf. Thomason and Kaufman 1988: 13–34). Such constraints are still thought to apply to structural interference, or pattern replication in the terms of Matras and Sakel (2007), and the often concomitant contact-induced grammaticalisation of non-native structures.
This paper suggests that a priori there are no typological constraints against pattern replication in general. It is proposed that typological differences between model and replica pattern are only of relevance during the grammaticalisation and maintenance of such patterns in the replica language; in other words, typological constraints do not apply at the stage of pattern replication. It will be argued that typology, in the form of system pressure, interacts with pattern frequency and socio-historical factors, which together determine retention, adaptation, or loss of a replicated pattern.
This argument is illustrated on the basis of three short studies of partial alignment change in Old Aramaic, Classical Armenian, and North-Eastern Neo-Aramaic, all of which have been in contact with Iranian languages for extended periods. In each case, Iranian ergative alignment patterns have been replicated, adapted, grammaticalised to varying degrees, and finally ousted in favour of nominative-accusative alignment. The loss of the replica pattern in each case is shown to be dependent on both typology, extent of bilingualism, and pattern frequency.
Atomic Absorption Spectrometry Methods to Access the Metal Solubility of Aerosols in Artificial Lung Fluid
Authors: Polezer Gabriela , Godoi Ricardo H. M. , Potgieter-Vermaak Sanja , de Souza Rodrigo A. F. , Andreoli Rita V. , Yamamoto Carlos I. , Oliveira Andrea 
Published: February 2020

Recent studies to quantify the health risks that fine particulate matter with an aerodynamic less than 2.5 µm (PM2.5) pose use in vitro approaches. One of these approaches is to incubate PM2.5 in artificial lysosomal fluid for a given period at body temperature. These body fluids used have a high ionic strength and as such can be challenging samples to analyze with atomic spectroscopy techniques. As PM2.5 is a primary health hazard because it is tiny enough to penetrate deep into the lungs and could, in addition, dissolve in the lung fluid it is important to quantify elements of toxic and/or carcinogenic concerns, reliably and accurately. Sophisticated instrumentation and expensive pre-treatment of challenging samples are not always available, especially in developing countries. To evaluate the applicability of graphite furnace atomic absorption spectrometry (GFAAS) without Zeeman correction capability to detect trace quantities of heavy metals leached from PM2.5 on to artificial lung fluid, univariate and multivariate approaches have been used for optimization purposes. The limits of quantification, LOQ, obtained by the optimized method were: 2 µg L−1 (Cu), 3 µg L−1 (Cr), 1 µg L−1 (Mn), and 10 µg L−1 (Pb). The addition/recovery experiments had a mean accuracy of: (Cu) 99 ± 7%; 110 ± 8% (Cr); 95 ± 9% (Mn), and 96 ± 11% (Pb). The average soluble fractions of PM2.5 incubated in artificial lysosomal fluid (ALF) for 1 h were: 1.2 ± 0.01 ng m−3 Cu, 0.4 ± 0.01 ng m−3 Cr, 0.6 ± 0.01 ng m−3 Mn, and 4.8 ± 0.03 ng m−3 Pb. Using historical elemental averages of PM2.5 in Curitiba (Cu 3.3 ng m−3, Cr 2.1 ng m−3, Mn 6.1 ng m−3, Pb 21 ng m−3), the percentage bioaccessibility were determined to be Cu 38%, Cr 20%, Mn 10%, and Pb 23%. The elemental values of the atmospheric soluble fraction of Cu, Cr, and Mn were below the inhalation risk concentrations. However, for Pb, the atmospheric soluble fraction exceeded the inhalation unit risk of 0.012 ng m−3. This robust and straightforward GF AAS method is pivotal for low and middle-income countries were most air pollution adverse effects occur and established lower-cost technologies are likely unavailable.
Anlotinib in treatment of an elderly patient with recurrent advanced SCLC
Authors: Zhang Ying , Jia Beili , Li Jing , Xu Xiaomei 
Published: February 2020

Introduction: An elderly patient with advanced small cell lung cancer who had a history of smoking and who had previously had tuberculosis and chronic kidney disease relapsed after classical treatment with etoposide combined with carboplatin. Methods: The patient was given chemotherapy again, with albumin-bound paclitaxel, etoposide capsules, apatinib, and other treatment. The last medication was apatinib. Results: After treatment with anlotinib, the patient has survived for 15 months with good quality of life. Conclusion: This is the first report on the precise efficacy of anlotinib in the treatment of advanced small cell lung cancer. Anlotinib is an important option for patients with small cell lung cancer.