bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural, Magnetic, Dielectric and Energy Storage Analysis of CoFe2O4@BaTiO3 and BaTiO3@CoFe2O4 Core-Shell Nano- Composites
Authors: SHEORAN NIDHI , Kumar Vinod , Kumar Ashok 
Published: June 2020

Abstract
Nano size spinel ferrite CoFe2O4 (CFO), ferroelectric BaTiO3 (BTO) and their core-shell nanocomposites BTO@CFO and CFO@BTO were synthesized using combination of chemical co-precipitation and sol-gel route respectively. The phase formation and crystallinity of bare CFO, BTO and their core-shell nanocomposites were verifiedviaX-ray diﬀraction pattern (XRD). High resolution transmission electron microscopy(HRTEM) revealed the core-shell structure of the nanocomposites.Magnetization measurements exhibitferromagnetic behaviour of all the samples except BTO in which superposition of weak ferromagnetic and diamagnetic response occurred due to its nanostructure. Magnetization versus temperature (M-T plot) measurements show anomaly near ferroelectric to paraelectric phase transition of BTO. Also,dielectric constant(ε¢) and tangent loss (tanδ) variation with respect to frequency (102 to 106 Hz) and temperature (300-700 K) were presented. ε¢-T curve of nanocomposites exhibit anomaly at the same temperature as observed in M-T plot of nanocomposites that indicate the inherent magneto-electric coupling in nanocomposites. Energy storage properties of BTO and nanocomposites have been examined via P-E loop analysis and confirmed that the sample CFO@BTO exhibit maximum energy storage efficiency.
Prevalence of Exclusive Breastfeeding Practice in Ethiopia and Its Association with Maternal Employment: A Systematic Review and Meta-analysis, 2019
Authors: Wake Getu Engida , Mittiku Yohannes Moges 
Published: June 2020

Abstract
Background: Exclusive breastfeeding defined as the practice of providing only breast-milk for an infant for the first 6 months of life without the addition of any other food or water, which recommends initiation of breastfeeding within one hour of life and continued breastfeeding for up to 2 years of age or more. Maternal employment is the most important factor contributing to the low practice of exclusive breastfeeding. However; the effect of maternal employment on exclusive breastfeeding is not investigated in Ethiopia.Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was used in this systematic review and meta-analysis. The databases used were; PubMed, Google Scholar, Science Direct, and Cochrane library were systematically searched. Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument (JBI-MAStARI) was used for critical appraisal of studies.Results: 36 studies were included in the final analysis after reviewing 541 studies in this meta-analysis yielding the pooled prevalence of EBF 59.79% (95% [CI] 54.58, 65.00) in Ethiopia.Those employed mothers were 57% less likely to practice exclusive breastfeeding in comparison to unemployed mothers in Ethiopia [OR] 0.43; 95% CI (0.3, 0.62).Conclusions: The overall prevalence of exclusive breastfeeding in this meta-analysis is low in comparison to the global recommendation of the practice of exclusive breastfeeding. Maternal employment was significantly associated with the practice of exclusive breastfeeding in comparison to their counterparts. Based On our review findings, we recommended that the Ethiopian government should increase legislated paid maternity leave after delivery beyond current paid maternity leave and implement policies that empower women and create a conducive environment for mothers to practice exclusive breastfeeding at workplace.
Social support and quality of life among female breast cancer patients at Tikur Anbessa Specialized Hospital, Ethiopia 2019:Cross-sectional study
Authors: Aberaraw Rahel , Hussien Jemal , Boka Abdisa , Teshome Roza , Yeshambel Addisu 
Published: June 2020

Abstract
Background Breast cancer is a major life-threatening public health problem worlwide. It is the most common form of cancer among women in many developing countries including Ethiopia. Social support could change the course of cancer and can influence the quality of life among breast cancer patients. Therefore, purpose of this study was to assess social support and quality of life among female breast cancer patients attending in Tikur Anbassa Specialized Hospital, Addis Ababa, Ethiopia 2019.Methods A Hospital-based cross-sectional study was conducted in Tikur Anbessa Specialized Hospital, Ethiopia from March to April 2019. A total of 214 female breast cancer patients were included and a systematic sampling method was used. A structured and pre-tested questionnaire was used. Data entry was done using epi data manager version 4.2. Data analysis was done using Statistical Package for Social Sciences version 25. Binary and multiple logistic regression was used to show the association of social support and quality of life. Variables significantly associated were declared at P-value <0.05 and 95%CI was used.Result A total of 214 women with breast cancer were recruited. Of the total participants, 124(58%) had good social support. It was found that participants who were college graduated (AOR=3, 95%CI: 1.5, 5.9 COR=3.2) and who had high monthly income(AOR=2.3, 95% CI: 1.2,8.5, COR= 5.39) were more likely to have good social support. It was also found that participants who were illiterate (AOR=3, 95%CI: 1.3,6.9, COR=4.8, p-value=0.008), who had systematic therapy side effects(AOR=3.8, 95%CI: 1.1,13, COR=4, p-value=0.035)and participants who had problem of appetite loss(AOR=3.5, 95%CI: 1.02,12COR=4, p-value= 0.047) were more likely to have affected QoL. Conclusion In this study finding, social support and, quality of life in breast cancer patients was low. Healthcare providers should enhance social support which may help to improve the quality of life of women with breast cancer.
Serum vitamin D deficiency in NICU hospitalized neonates and its association with neonatal outcomes
Authors: Mosayebi Ziba , Sagheb Setareh , Mirzendedel Mahsa , Movahedian Amir Hossein 
Published: June 2020

Abstract
Background: Neonates could be strongly affected by vitamin D deficiency-related adverse effects. In the present study, we aimed to determine the prevalence of vitamin D deficiency in the neonatal intensive care unit (NICU) hospitalized neonates and its possible relationship with neonatal outcomes. Methods: A prospective cross-sectional study was carried out in the NICU of Children's Medical Center (Tehran-Iran; 2015). The population study was NICU hospitalized neonates. Immediately on admission, serum sample for vitamin D measurement was obtained with routine blood sampling. Demographic and clinical data including serum levels of vitamin D and calcium, the causes of hospitalization, and neonatal outcome were recorded. The prevalence of vitamin D deficiency and its association with neonatal outcome were assessed. Results: One-hundred subjects entered the study. Vitamin D deficiency and insufficiency were present in 95% of neonates. There was a significant association between vitamin D status and season of birth (p=0.014); calcium status (p=0.025) and age at NICU admission (p<0.001). The mean value of vitamin D in term neonates was significantly lower than preterm neonates (p=0.031). There were no correlations between neonatal mortality with vitamin D (p=0.876) status.Conclusion: Vitamin D deficiency/insufficiency was highly prevalent among our NICU hospitalized neonates. There was no association between vitamin D level and neonatal outcomes. Neonates' vitamin D statuses were significantly correlated with the neonate's age at hospital admission, calcium status and season of birth. The measurement of serum vitamin D along with other routine blood tests in neonates who need NICU admission was strongly recommended.
Facilitating equal access to primary care for all: work experiences of health mediators in a primary health care model program in Hungary
Authors: Katona Cintia , Gutási Éva , Papp Magor , Varga Orsolya , Kósa Karolina 
Published: June 2020

Abstract
Background A Primary Care Model Programme was implemented in Hungary between 2013 and 2017 in order to increase access of disadvantaged population groups to primary care and to offer new preventive services for all clients. In a country with single-handed practices, four group practices or GP clusters were created in the Program. Six GPs comprised one cluster who together employed nonmedical health professionals and nonprofessional health mediators, the latter recruited from the serviced communities, many of them of Roma ethnicity. Health mediators were tasked by improving access of the local communities – including its vulnerable Roma members – to existing and new services. Methods As part of the program evaluation, structured interviews were conducted with all 40 health mediators employed at the time in the Program. Interviews were transcribed and content analysis was carried out. Results Three themes emerged from the transcripts. The first centered on the health mediators’ personal characteristics such as motivation to join the Program, the way their job increased their self-esteem, social status and health consciousness. Domains of the second theme of their work included importance of on-the-job training and of their insider knowledge of local communities, as well as their pride to have become members of the primary care team. The third theme covered overall functioning of the Program of which they had mostly positive opinions, notwithstanding some criticism regarding procurement. Conclusions Health mediators had earlier worked in various European countries specifically to improve access of Roma ethnic groups to health services but the Hungarian Model Programme was the first in which health mediators as non-professional workers became members of the primary care team. Their contribution and overwhelmingly positive experiences, along with their useful insights for improvement call for the establishment and funding of health mediator positions in primary care especially in areas with large numbers of disadvantaged Roma populations.
Interprofessional medication assessment among home care patients: Any impact on functioning? Results from a randomised controlled trial
Authors: Auvinen Kati Johanna , Voutilainen Ari , Jyrkkä Johanna , Lönnroos Eija , Mäntyselkä Pekka 
Published: June 2020

Abstract
BackgroundMultimorbidity and polypharmacy are related to the use of potentially inappropriate medicines and negative clinical outcomes including drug-related adverse events and functional decline. Home care clients are a vulnerable patient group often exposed to these risks. The aim of this study was to examine whether interprofessional medication assessment has effects on the functioning of home care patients.MethodsThe FIMA study was a randomised controlled intervention study comparing general practitioner-led interprofessional medication assessment conducted at the baseline of the study with usual care in six-month follow-up. We used linear mixed models (LMM) with a random subject effect to detect differences in outcome measures Katz index of Activities of Daily Living (ADL), Lawton and Brody scale of Instrumental Activities of Daily Living, Timed up and go-test (TUG), Mini-Mental State Examination, Geriatric Depression Scale and The 3-level version of EQ-5D between the usual care and intervention groups.ResultsHome care patients (n= 512) had major disease burden and functional limitations. Regarding TUG times, the LMM showed a statistically significant interaction between time and treatment (p=0.017) favoring the intervention. Correspondingly, ADL showed to have an interaction between time and treatment (p=0.025). The ADL score decreased in both groups, but the decline was steeper in the intervention group.ConclusionsInterprofessional medication assessment prevented worsening of mobility and balance performance in vulnerable older people.Trial registrationThe Interprofessional Medication Assessment for Older Patients, Clinical Trials.gov. NCT02398812. First registration, 26 March 2015. Retrospectively registered. https://www.clinicaltrials.gov/ct2/how/NCT02398812 .
Identification of best suitable repurposed drugs considering mutational spectra at RdRp (nsp12), 3CLpro (nsp 5) and PLpro (nsp 3) of SARS-CoV-2 in Indian population
Authors: Banerjee Shuvam , Dey Riju , Seal Sohan , Mondal Kousik Kr. , Bhattacharjee Pritha 
Published: June 2020

Abstract
Background and Objective: COVID-19 originated in Wuhan, China and expanded to different geographical location of the world with variation in its sequence due to mutation, consequent alteration in different protein structures; resulting in different interaction with the host body. The highly infectious and diverge character of the virus makes it imperative to identify the promising inhibitory compounds for RdRp, 3CLpro and PLpro as suitable antiviral drug target so that viral duplication can be prevented in the host body.Methods: RdRp, 3CLpro and PLpro sequences of Indian patients were retrieved from the database and MSA was employed to identify mutation at nsp 3, nsp 5 and nsp 12. Protein structures were modeled considering all possible combination of sequences abundant in India and docking was performed with repurposed drugs, currently under trial for COVID-19, using Autodock Vina to find out the suitable ones considering the mutational spectra of SARS-CoV-2 in India.Results: PLpro is found to be most vulnerable to mutations with four mutations found in >5% studied population whereas in 3CLpro none observed at the frequency > 5%, so far. Two mutations were reported among Indian population (>5%) at RdRp. Therefore 3CLpro and RdRp were further analysed as a suitable target for repurposed drugs. Elbasvir has come up as the most suitable drug to inhibit the activity of RdRp in Indian population, followed by Remdesivir and Methylprednisolone. TMC 310911, Lopinavir and Elbasvir again, found to be the best candidates for inhibiting 3CLpro.Interpretation and Conclusions: Remdesivir and Lopinavir(alone or in combination with Ritonavir), the most popular drugs of choice at recent times may be suitable to be used in Indian population, considering the mutational variations in Indian population. Among others, Elbasvir, TMC 310911 and Methylprednisolone are good choices for treating COVID-19.
Proposition of a new allosteric binding site for potential SARS-CoV-2 3CL protease inhibitors by utilizing molecular dynamics simulations and ensemble docking
Authors: Novak Jurica , Rimac Hrvoje , Kandagalla Shivananda , Pathak Prateek , Grishina Maria , Potemkin Vladimir 
Published: June 2020

Abstract
The SARS-CoV-2 3CL protease shows a high similarity with 3CL proteases of other beta-coronaviruses, such as SARS and MERS. It is the main enzyme involved in generating various non-structural proteins that are important for viral replication and is one of the most important proteins responsible for SARS-CoV-2 virulence. In this study, we have conducted ensemble docking of molecules from the DrugBank database using both crystallographic structure of the SARS-CoV-2 3CLpro, as well as five conformations obtained after performing a cluster analysis of a 300 ns molecular dynamics simulation. This procedure elucidated the inappropriateness of the active site for non-covalent inhibitors, but it has also shown that there exists an additional, more favorable, allosteric binding site, which could be a better target for non-covalent inhibitors, as it could prevent dimerization and activation of SARS-CoV-2 3CLpro.
Promising Polymeric Drug Carriers for Local Delivery: The Case of in situ Gels
Authors: Okur Neslihan Üstündağ , Yağcılar Ayşe Pınar , Siafaka Panoraia I. 
Published: June 2020

Background:
At present, the controlled local drug delivery is a very promising approach
compared to systemic administration, since it mostly targets the affected tissue. In fact, various drug
carriers for local delivery have been prepared with improved therapeutic efficacy.

Objective:
in situ polymer gels are drug delivery systems that not only present liquid characteristics
before their administration in body, but once they are administered, form gels due to gelation. Their
gelation mechanism is due to factors such as pH alteration, temperature change, ion activation or ultraviolet
irradiation. in situ gels offer various advantages compared to conventional formulations due to
their ability to release drugs in a sustainable and controllable manner. Most importantly, in situ gels can
be used in local drug delivery applications for various diseases.

Methods:
This review includes the basic knowledge and theory of in situ gels as well as their various
applications according to their administration route.

Results:
Various natural, semisynthetic, and synthetic polymers can produce in situ polymeric gels. For
example, natural polysaccharides such as alginic acid, chitosan, gellan gum, carrageenan etc. have been
utilized as in situ gels for topical delivery. Besides the polysaccharides, poloxamers, poly(Nisopropylacrylamide),
poly(ethyleneoxide)/ (lactic-co-glycolic acid), and thermosensitive liposome
systems can be applied as in situ gels. In most cases, in situ polymeric gels could be applied via various
administration routes such as oral, vaginal, ocular, intranasal and injectable.

Conclusion:
To conclude, it can be revealed that in situ gels could be a promising alternative carrier for
both chronic and immediate diseases.
Clin-mNGS: Automated Pipeline for Pathogen Detection from Clinical Metagenomic Data
Authors: Prasanna Akshatha , Niranjan Vidya 
Published: June 2020

Background:
Since bacteria are the earliest known organisms, there has been significant
interest in their variety and biology, most certainly concerning human health. Recent advances in
Metagenomics sequencing (mNGS), a culture-independent sequencing technology, have facilitated
an accelerated development in clinical microbiology and our understanding of pathogens.

Objective:
For the implementation of mNGS in routine clinical practice to become feasible, a
practical and scalable strategy for the study of mNGS data is essential. This study presents a robust
automated pipeline to analyze clinical metagenomic data for pathogen identification and
classification.

Method:
The proposed Clin-mNGS pipeline is an integrated, open-source, scalable, reproducible,
and user-friendly framework scripted using the Snakemake workflow management software. The
implementation avoids the hassle of manual installation and configuration of the multiple commandline
tools and dependencies. The approach directly screens pathogens from clinical raw reads and
generates consolidated reports for each sample.

Results:
The pipeline is demonstrated using publicly available data and is tested on a desktop Linux
system and a High-performance cluster. The study compares variability in results from different
tools and versions. The versions of the tools are made user modifiable. The pipeline results in quality
check, filtered reads, host subtraction, assembled contigs, assembly metrics, relative abundances of
bacterial species, antimicrobial resistance genes, plasmid finding, and virulence factors
identification. The results obtained from the pipeline are evaluated based on sensitivity and positive
predictive value.

Conclusion:
Clin-mNGS is an automated Snakemake pipeline validated for the analysis of microbial
clinical metagenomics reads to perform taxonomic classification and antimicrobial resistance
prediction.
Facile Template Free Shape Controlled Synthesis of α-Fe2O3 Truncated Octahedral Microstructures for the Thermal Decomposition of Ammonium Perchlorate
Authors: Narayanan Binitha , Haridas Vijayasree , Sugunan Sankaran 
Published: June 2020

Background:
The combustion behavior of the solid rocket propellants is highly dependent
on the thermal decomposition characteristics of Ammonium Perchlorate (AP) and thus low-cost, facile
and scalable preparation of the additive metal oxide-based catalysts is highly desired for the decomposition
of AP.

Objective:
A template free one-step low-cost preparation of α-Fe2O3 for its use as a catalyst in the decomposition
of AP.

Methods:
The catalyst is prepared by the simple heating of ferric chloride at 380 °C without any
chemical treatment. The material is characterized by X-Ray Diffraction (XRD), Scanning Electron
Microscopy (SEM), Transmission Electron Microscopy (TEM) and high-resolution TEM (HRTEM).
The catalytic thermal decomposition of AP over α-Fe2O3 was measured by Differential Scanning Calorimetry
(DSC).

Results:
The material exhibited a pure α-Fe2O3 crystalline phase. Morphological investigations revealed
the uniform formation of truncated octahedral microstructures of α-Fe2O3. DSC analysis confirmed
the two-step exothermic thermal decomposition of AP with decreased decomposition temperatures
with the catalytic assistance of α-Fe2O3.

Conclusions:
With the catalytic assistance of low-cost and easily prepared α-Fe2O3, the decomposition
temperature was decreased by 30 ºC when compared to the pure ammonium perchlorate and a high
decomposition heat release of 807 Jg-1 was observed.
De Geest is geen scepticus; de hele Luther
Authors: van Vlastuin W. 
Published: June 2020

The contemporary ‘turn to the subject’ also involves a ‘hermeneutical turn’, which raises the question whether Scripture can still speak for itself. Arnold Huijgen proposes a return behind this development, by way of Luther, in order to hear the viva vox Christi again in Scripture. This essay argues that Huijgen does not do justice to the centrality of justification and the moral and historical claims of Scripture. It concludes that we can indeed learn from a retrieval of the viva vox, providing that we maintain the depth of the justification of the ungodly and the breadth of the moral and historical claims of Scripture.
Reflection in a Mathematics Classroom
Authors: Teoh Sian Hoon , Singh Parmjit , Cheong Tau Han , Mohd Rasid Nor Syazwani 
Published: June 2020

This study was conducted to examine students’ reflection in terms of their beliefs and abilities to go through the activities in a problem-solving classroom. Hundred and twenty diploma students were randomly selected from a list of students who had registered in a course called Mathematics Thinking course at a university in Malaysia. The findings revealed that the students encountered difficulties in dealing with the problem-solving activities in the mathematics classroom. Despite giving their best efforts, the students still found challenges in comprehending the context of the issues rendered to them calling for the much indispensable collaboration or peer assistance.
Keywords: Written reflection; Mathematics classroom; Problem-solving.
eISSN: 2398-4287 © 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v5iSI1.2289