bluuebunny/crossref_metadata_2025_split huggingface dataset:
Usefulness of 18F‐fluorodeoxyglucose positron emission tomography/computed tomography for predicting the prognosis and treatment response of neoadjuvant therapy for pancreatic ductal adenocarcinoma
Authors: Yokose Takahiro , Kitago Minoru , Matsusaka Yohji , Masugi Yohei , Shinoda Masahiro , Yagi Hiroshi , Abe Yuta , Oshima Go , Hori Shutaro , Endo Yutaka , Toyama Kenji , Iwabuchi Yu , Takemura Ryo , Ishii Ryota , Nakahara Tadaki , Okuda Shigeo , Jinzaki Masahiro , Kitagawa Yuko 
Published: April 2020

AbstractBackgroundThe Response Evaluation Criteria in Solid Tumors (RECIST) for computed tomography (CT) is preoperatively used to evaluate therapeutic effects. However, it does not reflect the pathological treatment response (PTR) of pancreatic ductal adenocarcinoma (PDAC). The Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) for positron emission tomography (PET)/CT is effective in other cancers. This study aimed to confirm the usefulness of PERCIST and the prognostic utility of PET/CT for PDAC.MethodsForty‐two consecutive patients with PDAC who underwent neoadjuvant therapy (NAT) and pancreatectomy at our institution between 2014 and 2018 were retrospectively analyzed. We evaluated the treatment response and prognostic significance of PET/CT parameters and other clinicopathological factors.ResultsTwenty‐two patients who underwent PET/CT both before and after NAT with the same protocol were included. RECIST revealed stable disease and partial response in 20 and 2 cases, respectively. PERCIST revealed stable metabolic disease, partial metabolic response, and complete metabolic response in 8, 9, and 5 cases, respectively. The PTR was G3, G2, and G1 in 8, 12, and 2 cases, respectively. For comparing the concordance rates between PTR and each parameter, PERCIST (72.7% [16/22]) was significantly superior to RECIST (36.4% [8/22]) (P = .017). The area under the curve survival values of PET/CT parameters were 0.777 for metabolic tumor volume (MTV), 0.500 for maximum standardized uptake value, 0.554 for peak standardized uptake value corrected for lean body mass, and 0.634 for total lesion glycolysis. A 50% cut‐off value for the MTV reduction rate yielded the largest difference in survival between responders and nonresponders. On multivariate analysis, MTV reduction rates < 50% were independent predictors for relapse‐free survival (hazard ratio [HR], 3.92; P = .044) and overall survival (HR, 14.08; P = .023).ConclusionsPERCIST was more accurate in determining NAT’s therapeutic effects for PDAC than RECIST. MTV reduction rates were independent prognostic factors for PDAC.
Retracted: The lncRNA SNHG5‐mediated miR‐205‐5p downregulation contributes to the progression of clear cell renal cell carcinoma by targeting ZEB1
Authors: Xiang Wei , Lv Lei , Zhou Gaofeng , Wu Wei , Yuan Jingdong , Zhang Chuanhua , Jiang Guosong 
Published: April 2020

ABSTRACTRecent findings have unraveled the critical functions of the long noncoding RNA (lncRNA) SNHG5 in human malignancies. Nevertheless, the role and mechanism of SNHG5 in clear cell renal cell carcinoma (ccRCC) are still elusive. In our study, substantially higher abundance of SNHG5 was observed in ccRCC specimens and cell lines, and increased SNHG5 expression was intimately correlated with tumor size, tumor‐node‐metastasis (TNM) stage, lymph node invasion, and distant metastases in patients with ccRCC. SNHG5 knockdown obviously suppressed the proliferative, migratory, and invasive capabilities of ccRCC cells, whereas SNHG5 overexpression induced the opposite effects. Mechanistically, SNHG5 activated the transcription of ZEB1, which exerts a pivotal role in modulation of epithelia‐mesenchymal transition (EMT) and tumor metastasis. SNHG5 was then shown to act as an endogenous sponge for miR‐205‐5p, which targets ZEB1 in ccRCC. Moreover rescue experiments revealed that SNHG5 promotes ccRCC cell proliferation, migration, and invasion in a miR‐205‐5p‐dependent manner. Additionally, in vivo assays further indicated that overexpression or silencing of SNHG5 in ccRCC cells promoted or suppressed the tumorigenesis and metastasis, respectively. Altogether, the present data provide the first evidence that the lncRNA SNHG5 has an oncogenic role in ccRCC through the SNHG5/miR‐205‐5p/ZEB1 signaling axis and represents a novel potential therapeutic regimen against ccRCC.
Introduction to the Special Section ‘Innovative counselling and psychotherapy research methods’: Defining the future of counselling and psychotherapy research
Authors: Kramer Ueli , Timulak Ladislav 
Published: April 2020

AbstractIn the call for papers for this Special Issue, we sought submissions that would introduce innovative methods with the potential to shape counselling and psychotherapy research into the future. We believe that we accomplished this goal and that this issue introduces a range of valuable examples of current innovations in counselling and psychotherapy research methods. Through the review process, we encouraged authors to offer practical guidelines on how to innovatively assess and analyse change and other relevant aspects of therapy. We also guided authors to not only provide the field with an update on cutting‐edge methodology, but also describe these methods in a practice‐friendly way. As such, the Special Issue aims at becoming a building block for future practice‐friendly research in counselling and psychotherapy.
Olaparib‐Based Photoaffinity Probes for PARP‐1 Detection in Living Cells
Authors: Voorneveld Jim , Florea Bogdan I. , Bakkum Thomas , Mendowicz Rafal J. , van der Veer Miriam S. , Gagestein Berend , van Kasteren Sander I. , van der Stelt Mario , Overkleeft Herman S. , Filippov Dmitri V. 
Published: April 2020

AbstractThe poly‐ADP‐ribose polymerase (PARP) is a protein from the family of ADP‐ribosyltransferases that catalyzes polyadenosine diphosphate ribose (ADPR) formation in order to attract the DNA repair machinery to sites of DNA damage. The inhibition of PARP activity by olaparib can cause cell death, which is of clinical relevance in some tumor types. This demonstrates that quantification of PARP activity in the context of living cells is of great importance. In this work, we present the design, synthesis and biological evaluation of photo‐activatable affinity probes inspired by the olaparib molecule that are equipped with a diazirine for covalent attachment upon activation by UV light and a ligation handle for the addition of a reporter group of choice. SDS‐PAGE, western blotting and label‐free LC‐MS/MS quantification analysis show that the probes target the PARP‐1 protein and are selectively outcompeted by olaparib; this suggests that they bind in the same enzymatic pocket. Proteomics data are available via ProteomeXchange with identifier PXD018661.
Metallic Nanoparticle‐Enabled Sensing of a Drug‐of‐Abuse: An Attempt at Forensic Application
Authors: Hu Ming , Han Qinyu , Xing Bengang 
Published: April 2020

Abstractγ‐Hydroxybutyric acid (GHB) functions as a depressant on the central nerve system and serves as a pharmaceutical agent in the treatment of narcolepsy and alcohol withdraw. In recent years, GHB has been misused as a recreational drug due to its ability to induce euphoric feelings. Moreover, it has gained increasing attention as a popular drug of abuse that is frequently related to drug‐facilitated sexual assaults. At the moment, detection methods based on chromatography exhibit extraordinary sensitivity for GHB sensing. However, such techniques require complicated sample treatment prior to analysis. Optical sensors provide an alternative approach for rapid and simple analysis of GHB samples. Unfortunately, currently reported probes are mostly based on hydrogen bonding to recognize GHB, and this raises concerns about, for example, the lack of specificity. In this work, we report a bioinspired strategy for selective sensing of GHB. The method is based on specific enzyme recognition to allow highly selective detection of GHB with minimum interference, even in a complex sample matrix (e. g., simulated urine). In addition, the result can be obtained by either quantitative spectroscopy analysis or colorimetric change observed by the naked‐eye, thus demonstrating its potential application in drug screening and forensic analysis.
Exogenous spermine attenuates myocardial fibrosis in diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress and the canonical Wnt signaling pathway
Authors: Hu Jing , Lu Xiaoxiao , Zhang Xinying , Shao Xiaoting , Wang Yuehong , Chen Junting , Zhao Bingbing , Li Siwei , Xu Changqing , Wei Can 
Published: April 2020

AbstractMyocardial fibrosis is one of the main pathological manifestations of diabetic cardiomyopathy (DCM). Spermine (SPM), a product of polyamine metabolism, plays an important role in many cardiac diseases including hypertrophy, ischemia, and infarction, but its role in diabetic myocardial fibrosis has not been clarified. This study aimed to investigate the role of polyamine metabolism, specifically SPM, in diabetic myocardial fibrosis and to explore the related mechanisms. We used intraperitoneal injection of streptozotocin (STZ, 60 mg/kg) in Wistar rats and high glucose (HG, 40 mM) stimulated cardiac fibroblasts (CFs) to established a type 1 diabetes (T1D) model in vivo and in vitro, which were pretreated with exogenous SPM (5 mg/kg per day and 5 μM). The results showed that hyperglycemia induced the expression of the key polyamine synthesis enzyme ornithine decarboxylase (ODC) decreased and the key catabolic enzyme spermidine/spermine N1‐acetyltransferase (SSAT) increased compared with those in the control group. The body weight, blood insulin level, and cardiac ejection function were decreased, while blood glucose, heart weight, the ratio of heart weight to body weight, myocardial interstitial collagen deposition, and endoplasmic reticulum stress (ERS)‐related protein (glucose‐regulated protein‐78, glucose‐regulated protein‐94, activating transcription factor‐4, and C/EBP homology protein) expression in the T1D group were all significantly increased. HG also caused an increased expression of Wnt3, β‐catenin (in cytoplasm and nucleus), while Axin2 and phosphorylated β‐catenin decreased. Exogenous SPM improved the above changes caused by polyamine metabolic disorders. In conclusion, polyamine metabolism disorder occurs in the myocardial tissue of diabetic rats, causing myocardial fibrosis and ERS. Exogenous SPM plays a myocardial protective role via inhibiting of ERS and the canonical Wnt/β‐catenin signaling pathway.
Pigmented fungiform papillae of the tongue in a Japanese child
Authors: Sugiyama Yuki , Hayashi Katsuhiko , Takayama Takeshi 
Published: April 2020

AbstractPigmented fungiform papillae of the tongue (PFPT) does not require invasive investigation and treatment. However, if the patient requests treatment for aesthetic reasons, and the pigmentation is focally distributed, an excisional biopsy can be chosen for both diagnosis and treatment.
An unusual mechanism of spinal cord injury due to active neck stretching and its functional implications
Authors: Ullah Sami , Qureshi Ahmad Zaheer , Tantawy Sherif Samir , AlJaizani Yazid Antar 
Published: April 2020

AbstractSpinal cord injury without radiological abnormality is a rare entity and has not been reported to occur secondary to active neck stretching. The case report highlights the possible mechanisms of injury and functional outcomes of multidisciplinary rehabilitation.
Vision loss, tractional retinal detachment, and profound anemia due to rectal carcinoma
Authors: Yamamoto Akira , Nishimura Yoshito , Obika Mikako , Morizane Yuki , Otsuka Fumio 
Published: April 2020

AbstractProfound anemia can cause severe proliferative retinopathy and tractional retinal detachment; therefore, it is important to closely investigate the cause of anemia. Endoscopy and computed tomography are valuable tools for this purpose.
Pruritic annular and vesicular eruption on trunk and extremities
Authors: Koumaki Dimitra , Koumaki Vasiliki , Boumpoucheropoulos Sotirios , Katoulis Alexander , Kouvidou Charikleia , Stefanidou Maria , Bitados Panagiotis P. , Baltaga Ludmila , Miaris Orestis , Evangelou George , Krueger‐Krasagakis Sabine Elke , Krasagakis Konstantinos 
Published: April 2020

AbstractWe report a case of linear IgA bullous dermatosis, a rare autoimmune blistering disorder that usually presents with the abrupt onset of tense bullae. We also emphasize the importance of direct immunofluorescence for the definitive diagnosis.
Rare case of circumferential esophageal peeling
Authors: Tominaga Kentaro , Tsuchiya Atsunori , Sato Hiroki , Ishii Yui , Takeda Nobutaka , Natsui Kazuki , Kawata Yuzo , Kimura Naruhiro , Arao Yoshihisa , Takeuchi Suguru , Hayashi Kazunao , Yokoyama Junji , Terai Shuji 
Published: April 2020

AbstractThis report highlights the easy peeling of the esophageal epithelium with Nikolsky phenomenon after swallowing the foreign body and the healing status of the esophagus only 3 days later in a patient of pemphigus vulgaris.
Crack and deformation behavior of composite beams using partial‐depth precast concrete units
Authors: Mager Matthias , Geißler Karsten 
Published: April 2020

AbstractIn ranges with negative moments, crack formation influences the structural behavior of statically indeterminate composite beams under service conditions. Composite beams with partial‐depth precast concrete units show some particularities, which cannot be described accurately using the established methods of calculation. This article presents methods of calculation, which can be used to cover the specific structural behavior and describe crack formation, crack widths and deformations realistically.
Benzimidazole Derivatives as Novel Zika Virus Inhibitors
Authors: Hue Bui Thi Buu , Nguyen Phuong Hong , De Tran Quang , Van Hieu Mai , Jo Eunji , Van Tuan Nguyen , Thoa Than Thi , Anh Le Duc , Son Nguyen Hoang , La Duc Thanh Danh , Dupont‐Rouzeyrol Myrielle , Grailhe Regis , Windisch Marc P. 
Published: April 2020

AbstractWe have synthesized 50 benzimidazole (BMZ) derivatives with 1,2‐phenylenediamines and aromatic aldehydes under mild oxidation conditions by using inexpensive, nontoxic inorganic salt sodium metabisulfite in a one‐pot condensation reaction and screened their ability to interfere with Zika virus (ZIKV) infection utilizing a cell‐based phenotypic assay. Seven BMZs inhibited an African ZIKV strain with a selectivity index (SI=CC50/EC50) of 9–37. Structure‐activity relationship analysis demonstrated that substitution at the C‐2, N‐1, and C‐5 positions of the BMZ ring were important for anti‐ZIKV activity. The hybrid structure of BMZ and naphthalene rings was a structural feature responsible for the high anti‐ZIKV activity. Importantly, BMZs inhibited ZIKV in human neural stem cells, a physiologically relevant system considering the severe congenital anomalies, like microcephaly, caused by ZIKV infection. Compound 39 displayed the highest antiviral efficacy against the African ZIKV strain in Huh‐7 (SI>37) and neural stem cells (SI=12). Compound 35 possessed the highest activity in Vero cells (SI=115). Together, our data indicate that BMZs derivatives have to be considered for the development of ZIKV therapeutic interventions.
Optimization of nitrogen fertilizer management for improving rice grain yield and nutrient accumulation and mobilization in saline‐alkaline soils
Authors: Guo Xiaohong , Jiang Hongfang , Lan Yuchen , Wang Heying , Xu Lingqi , Yin Dawei , Zheng Guiping , Lv Yandong 
Published: April 2020

AbstractSoil salinity and alkalinity are key abiotic stresses that limit crop growth and yield worldwide. Balanced N fertilization is important for improving rice (Oryza sativa L.) yield via efficient utilization of P and K under saline and alkaline soil conditions. In this study, a japonica rice cultivar, Kenjing 8, was used to investigate the effects of N fertilizer on rice yield, as well as N, P, and K status, in a 2‐yr field experiment in saline‐alkaline soil in Heilongjiang Province, northeast China. The plants were assigned to the following five treatment groups: no N fertilizer, or conventional, balanced, reduced, and postponed N fertilizer management. Compared with conventional N management practice, balanced and reduced N management practices increased the concentrations of N, P, and K in the leaves, stem‐sheaths, and panicles at full heading (FH) and maturity; however, postponed N management led to the opposite results. Balanced N management increased N, P, and K mobilization to the leaves (from FH to maturity) by 49, 43, and 67%, respectively, resulting in the highest crop yields among all the N management practices studied. Furthermore, rice yield was positively correlated with N, P, and K accumulation and rates of nutrient mobilization to the leaves, stem‐sheaths, and panicles at maturity. The application of 150 or 135 kg N ha−1, and the proportion of 4:3:1:2 in the pre‐transplanting, mid‐tillering, panicle initiation, and panicle differentiation stages, may increase rice yield and facilitate efficient utilization of nutrients in saline‐alkaline soil.
Stakeholder engagement in sustainability reporting: A classification model
Authors: Stocker Fabricio , de Arruda Michelle P. , de Mascena Keysa M. C. , Boaventura João M. G. 
Published: April 2020

AbstractThis study presents analysis criteria used to identify and classify the level of engagement between firms and stakeholders. We analyzed 119 sustainability reports disclosed by companies operating in the energy sector from 40 different countries. Our study adopted the following stakeholder engagement classification levels: information strategy, response strategy, and involvement strategy. The results show that, although strategic involvement actions are at a high quality level, they are the least adopted by the companies studied, which concentrate their engagement actions at the least complex levels. Our contribution is to propose a matrix of engagement strategies as a tool that is formed by nine strategic quadrants, providing clear differentiation between engagement strategies that can be used to improve sustainability reports and to rethink the quality and focus of actions with stakeholders.
Zeolite‐Assisted Lignin‐First Fractionation of Lignocellulose: Overcoming Lignin Recondensation through Shape‐Selective Catalysis
Authors: Subbotina Elena , Velty Alexandra , Samec Joseph S. M. , Corma Avelino 
Published: April 2020

AbstractOrganosolv pulping releases reactive monomers from both lignin and hemicellulose by the cleavage of weak C−O bonds. These monomers recombine to form undesired polymers through the formation of recalcitrant C−C bonds. Different strategies have been developed to prevent this process by stabilizing the reactive monomers (i.e., lignin‐first approaches). To date, all reported approaches rely on the addition of capping agents or metal‐catalyzed stabilization reactions, which usually require high pressures of hydrogen gas. Herein, a metal‐ and additive‐free approach is reported that uses zeolites as acid catalysts to convert the reactive monomers into more stable derivatives under organosolv pulping conditions. Experiments with model lignin compounds showed that the recondensation of aldehydes and allylic alcohols produced by the cleavage of β‐O‐4′ bonds was efficiently inhibited by the use of protonic β zeolite. By applying a zeolite with a preferred pore size, the bimolecular reactions of reactive monomers were effectively inhibited, resulting in stable and valuable monophenolics. The developed methodology was further extended to birch wood to yield monophenolic compounds and value‐added products from carbohydrates.
Exploiting classification for fountain data estimation in wireless sensor networks
Authors: Belabed Fatma , Bouallegue Ridha 
Published: April 2020

SummaryIn order to correct and avoid channel error, fountain codes were the best solution by limiting feedback channels and reducing energy consumption. Multi‐hops transmission is the principal limitation of the deployment and the use of these codes. Indeed, relayed transmission conducts to the generation of useless data, named overflow leading to a waste of energy, the most critical issue, and the big challenge in WSN. In this paper, based on a clustered architecture and estimation, we consider a distributed estimation scheme composing of sensor members and the cluster head. In order to reduce the number of a useless encoded packet generated as well as the impact of the overflow, we determine the optimal minimal number of encoded packets needed for data decoding. Sensor observations are encoded using fountain codes, and then messages are collected at the cluster head where a final estimation is provided within learning method. Then messages are collected at the cluster head where a final estimation is provided with a classification based on Bayes rule. The main goal of this paper is to determine the number of encoded packets by exploiting the classification model for fountain data estimation to minimize the overflow and extend the network lifetime.
Panmixia across elevation in thermally sensitive Andean dung beetles
Authors: Linck Ethan B. , Celi Jorge E. , Sheldon Kimberly S. 
Published: April 2020

AbstractJanzen's seasonality hypothesis predicts that organisms inhabiting environments with limited climatic variability will evolve a reduced thermal tolerance breadth compared with organisms experiencing greater climatic variability. In turn, narrow tolerance breadth may select against dispersal across strong temperature gradients, such as those found across elevation. This can result in narrow elevational ranges and generate a pattern of isolation by environment or neutral genetic differentiation correlated with environmental variables that are independent of geographic distance. We tested for signatures of isolation by environment across elevation using genome‐wide SNP data from five species of Andean dung beetles (subfamily Scarabaeinae) with well‐characterized, narrow thermal physiologies, and narrow elevational distributions. Contrary to our expectations, we found no evidence of population genetic structure associated with elevation and little signal of isolation by environment. Further, elevational ranges for four of five species appear to be at equilibrium and show no decay of genetic diversity at range limits. Taken together, these results suggest physiological constraints on dispersal may primarily operate outside of a stable realized niche and point to a lower bound on the spatial scale of local adaptation.