bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spontaneous Formation of Plasmoid during Early Magnetic Reconnection Phase of Two Merging Tokamaks
Authors: Cao Qinghong , Cai Yunhan , Akimitsu Moe , Xiang Junguang , Ahmadi Tara , Tanaka Haruaki , Tanabe Hiroshi , Ono Yasushi 
Published: July 2020

AbstractA new type of spontaneous formation of plasmoid is observed in our toroidal plasma merging experiment on TS‐6 using a newly developed high‐resolution magnetic probe array, which has axially gyro‐scale spatial resolution (ΔZ ∼ 1.1 cm). In the axially elongated new machine, the plasmoid is formed near the mid‐plane with a configuration of two X‐points in the early phase of magnetic reconnection when the initial two flux tubes (merging tokamaks) are still in their respective formation region. The plasmoid is then merged with the major upstream plasmas at the two X‐points, which finally triggers the increment of reconnection speed. © 2020 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.
Acylglycerol kinase promotes the stemness of nasopharyngeal carcinoma cells by promoting β‐catenin translocation to the nucleus through activating PI3K/Akt pathway
Authors: Zhao Qi , Sun Peng , Qin Songbing , Liu Jisheng 
Published: July 2020

AbstractRecent evidences show that acylglycerol kinase (AGK) expression is related to the occurrence and development of various human cancers. However, its roles in nasopharyngeal carcinoma (NPC) progression are still unclear. This work aims to explore the roles of AGK in NPC cell stemness. It was shown that AGK expression was higher in NPC tissues compared to the adjacent tissues. Online dataset analysis revealed that AGK expression was negatively correlated with the overall survival of NPC patients. Gain and loss of functional experiments demonstrated that AGK positively regulated the stemness of NPC cells, as evident by the change of the tumor sphere‐formation ability, ALDH1 activity and expression of stemness critical regulators. KEGG analysis were performed to determine the potential pathways of AGK involved in NPC cell stemness and showed that the PI3K/Akt pathway exhibited the most correlation with AGK expression. Further mechanistic studies confirmed that AGK promoted the stemness of NPC cells through activating the PI3K/Akt pathway, and thus enhancing β‐catenin accumulation in nucleus. This study demonstrates a novel AGK/PI3K/Akt/β‐catenin axis involving in NPC cell stemness.
Fatal attraction: The roles of ribosomal proteins in the viral life cycle
Authors: Miller Clare M. , Selvam Sangeetha , Fuchs Gabriele 
Published: July 2020

AbstractUpon viral infection of a host cell, each virus starts a program to generate many progeny viruses. Although viruses interact with the host cell in numerous ways, one critical step in the virus life cycle is the expression of viral proteins, which are synthesized by the host ribosomes in conjunction with host translation factors. Here we review different mechanisms viruses have evolved to effectively seize host cell ribosomes, the roles of specific ribosomal proteins and their posttranslational modifications on viral RNA translation, or the cellular response to infection. We further highlight ribosomal proteins with extra‐ribosomal function during viral infection and put the knowledge of ribosomal proteins during viral infection into the larger context of ribosome‐related diseases, known as ribosomopathies.This article is categorized under:
Translation > Translation Mechanisms
Translation > Translation Regulation
Spontaneously broken boosts and the Goldstone continuum
Authors: Alberte Lasma , Nicolis Alberto 
Published: July 2020

Abstract
The spontaneous breaking of boost invariance is ubiquitous in nature, yet the associated Goldstone bosons are nowhere to be seen. We discuss why some subtleties are to be expected in the Goldstone phenomenon for spontaneously broken boosts, and derive the corresponding quantum mechanical, non-perturbative Goldstone theorem. Despite similarities with more standard Goldstone theorems, we show by examples that ours can be obeyed by quite unusual spectra of low-energy excitations. In particular, for non- relativistic Fermi liquids, we prove that it is obeyed by the particle-hole continuum. To the best of our knowledge, this is the first example of a Goldstone theorem obeyed by a continuum rather than by (approximately stable) single-particle Goldstone boson states in an interacting theory at zero temperature.
The Detectable Subspace for the Friedrichs Model: Applications of Toeplitz Operators and the Riesz–Nevanlinna Factorisation Theorem
Authors: Naboko S. , Wood I. 
Published: July 2020

AbstractWe discuss how much information on a Friedrichs model operator (a finite rank perturbation of the operator of multiplication by the independent variable) can be detected from ‘measurements on the boundary’. The framework of boundary triples is used to introduce the generalised Titchmarsh–Weyl M-function and the detectable subspaces which are associated with the part of the operator which is ‘accessible from boundary measurements’. In this paper, we choose functions arising as parameters in the Friedrichs model in certain Hardy classes. This allows us to determine the detectable subspace by using the canonical Riesz–Nevanlinna factorisation of the symbol of a related Toeplitz operator.
Mechanical properties and compositional characteristics of beet (Beta vulgaris L.) varieties and their response to nitrogen application
Authors: Schäfer Judith , Hale Julia , Hoffmann Christa M. , Bunzel Mirko 
Published: July 2020

AbstractMechanical properties of sugar beet are important during harvesting and processing. To potentially correlate mechanical properties with structural features of cell wall polymers, four different Beta varieties (Beta vulgaris L.) were characterized for their mechanical properties and cell wall composition. In addition, the influence of nitrogen fertilization was analyzed. Additional nitrogen fertilization only slightly influenced mechanical properties and cell wall composition. Hardly any structural differences of cell wall polysaccharides were observed for all Beta varieties. Slight differences in alcohol insoluble residue and protein contents, in amino acid profiles of proteins, and in esterification degree of pectins were found. The Beta varieties differed in their contents of cell wall bound phenolic components, and particularly in their dry matter contents. Analyses of mechanical properties of the Beta varieties demonstrated differences in tissue firmness and compressive strength. However, no evidence was found that the observed differences of cell wall composition are responsible for the divergent mechanical properties, with the exception of water contents that were higher in samples with less compressive strength.
Spectral Truncations in Noncommutative Geometry and Operator Systems
Authors: Connes Alain , van Suijlekom Walter D. 
Published: July 2020

AbstractIn this paper we extend the traditional framework of noncommutative geometry in order to deal with spectral truncations of geometric spaces (i.e. imposing an ultraviolet cutoff in momentum space) and with tolerance relations which provide a coarse grain approximation of geometric spaces at a finite resolution. In our new approach the traditional role played by$$C^*$$C∗-algebras is taken over by operator systems. As part of the techniques we treat$$C^*$$C∗-envelopes, dual operator systems and stable equivalence. We define a propagation number for operator systems, which we show to be an invariant under stable equivalence and use to compare approximations of the same space. We illustrate our methods for concrete examples obtained by spectral truncations of the circle. These are operator systems of finite-dimensional Toeplitz matrices and their dual operator systems which are given by functions in the group algebra on the integers with support in a fixed interval. It turns out that the cones of positive elements and the pure state spaces for these operator systems possess a very rich structure which we analyze including for the algebraic geometry of the boundary of the positive cone and the metric aspect i.e. the distance on the state space associated to the Dirac operator. The main property of the spectral truncation is that it keeps the isometry group intact. In contrast, if one considers the other finite approximation provided by circulant matrices the isometry group becomes discrete, even though in this case the operator system is a$$C^*$$C∗-algebra. We analyze this in the context of the finite Fourier transform on the cyclic group. The extension of noncommutative geometry to operator systems allows one to deal with metric spaces up to finite resolution by considering the relation$$d(x,y)< \varepsilon $$d(x,y)<εbetween two points, or more generally a tolerance relation which naturally gives rise to an operator system.
Assessing Post‐operative Pain with Self‐reports via the Jerrycan Pain Scale in Rural Kenya
Authors: Mwachiro Michael , Mwachiro Elizabeth , Wachu MaryAnne , Koske Wilter , Thure Linda , Parker Robert K. , White Russell E. 
Published: July 2020

AbstractBackgroundPerioperative pain management is an essential component to improving patient outcomes. Measurement and description of pain are challenging and vary in different contexts. The objective of this study was to assess the utility of self‐reporting via visual analogue scales using the Jerrycan visual analogue scale in the assessment of post‐operative pain and to validate the use of this novel scale compared to standard pain scales.Materials and methodsTwo hundred and forty‐one inpatients who underwent surgical procedures were prospectively assessed for post‐operative pain over a 12‐month period from February 2016 to January 2017. Participants included patients who underwent general surgery, orthopedic and obstetrics/gynecology procedures. On post‐operative day one, four scales were assessed: Verbal scale, Hands scale, Faces scale and Jerrycan scale, each ranging from 0–5. Scores for each scale were recorded, and agreements between scales were calculated using kappa values and Spearman's rank coefficients.ResultsThe mean age was 34.8 years and more female subjects were evaluated (68%). The majority received spinal anesthesia (61%). The mean pain score was 2.5 for all scales. The Jerrycan (0.50) and Faces scales (0.43) had moderate agreements with the Verbal scale. Participants preferred the Jerrycan Pain Scale.ConclusionThe Jerrycan pain scale had comparable scores and reasonable agreement with 3 other pain scales among a cohort of post‐operative patients. Patient preference and ease of use of the Jerrycan scale may impact assessment and management of pain in a rural African setting. This scale may be adapted for use in similar resource settings for post‐operative pain management.
Validity and reliability of the Patient Health Questionnaire-8 in Swedish for individuals with systemic sclerosis
Authors: Mattsson Malin , Sandqvist Gunnel , Hesselstrand Roger , Nordin Annica , Boström Carina 
Published: July 2020

Abstract
Background
Depressive symptoms are common in rheumatic diseases and influence patients’ quality of life. The Patient Health Questionnaire-9 (PHQ-9), which assesses symptoms of depression, is valid in English in patients with systemic sclerosis (SSc). However, the measurement properties of the PHQ-8 (short version of the PHQ-9) have not been evaluated in Swedish patients with SSc.

Objective
To investigate different aspects of validity and reliability of the PHQ-8 in Swedish (PHQ-8 Swe) for individuals with SSc.

Methods
A total of 101 patients with SSc participated. Content validity was evaluated via interviews of 11 patients and 10 health professionals. Construct validity, internal consistency test–retest reliability, and floor/ceiling effects were evaluated in 90 patients.

Results
Content validity was satisfactory, but some linguistic adjustments were made. Confirmatory factor analysis supported a better fit for a two-factor structure. Moderate-to-strong correlations were found between the PHQ-8 Swe and scleroderma HAQ including VAS (rs = 0.4–0.7); Multidimensional Assessment of Fatigue (rs = 0.7); RAND-36 subscales (rs = − 0.5 to − 0.8); and lung disease severity (Medsger scores) (rs = 0.4). There were weak correlations (rs = <0.4) between the PHQ-8 Swe and modified Rodnan skin score; and vascular, heart, and kidney disease severity. Cronbach’s alpha was 0.85, corrected item-to-total correlations were >0.40, and the ICC for the total score was 0.83. No floor/ceiling effects were found.

Conclusion
The PHQ-8 Swe has satisfactory content validity and sufficient reliability in patients with in majority limited SSc. It is more strongly associated with self-reported disability, pain, disease interferences with daily activities, fatigue, and quality of life than with disease severity, except for a moderate association with lung severity.
Thrombocytopenia: is it a prognostic factor for development of post-hemorrhagic hydrocephalus in neonates?
Authors: El Damaty Ahmed , Giannoni Luca , Unterberg Andreas , Baechli Heidi 
Published: July 2020

Abstract
Purpose
Post-hemorrhagic hydrocephalus (PHH) is a rare but serious complication among premature babies in the neonatal intensive care unit. The causes of PHH are still not entirely understood, and its prevention and treatment are controversial. We tried to analyze the risk factors for such complication in our cohort.

Methods
We reviewed our neonatology data bank and included all preterms below 28 weeks who were born in the period between 1999 and 2014 and suffered from an intraventricular hemorrhage (IVH). We reviewed gestational age, gender, birth weight, type of birth, IVH degree, comorbidities, therapy, complications, time to event, protein content of cerebrospinal fluid, and clinical follow-up.

Results
We identified 180 patients, divided into two subgroups, “B1” with 37 cases (IVH + PHH) and “B2” with 143 cases (IVH − PHH). In group B1, the presence of IVH grades I, II, III, or IV was in 11%, 19%, and 70% respectively. Nineteen patients were treated with a ventricular access device (VAD) or external ventricular drain (EVD). A total of 20 shunts were implanted, with 11 revisions (55%). One patient suffered from thrombocytopenia. In subgroup B2, 51% showed IVH grade I, whereas severe IVH grades were only present in 22%. 25.9% suffered from thrombocytopenia. Thrombocytopenia was significantly higher in patients who did not develop PHH (p value: 0.002).

Conclusion
According to our results, thrombocytopenia could play a decisive role in avoiding development of PHH as a sequel of IVH. We recommend a randomized controlled trial to assess the possible efficacy of antiplatelet drugs in avoiding PHH in this vulnerable group.
Transfer of an interprofessional emergency caesarean section training program: using questionnaire combined with outcome data of newborn
Authors: Flentje Markus , Eismann Hendrik , Höltje Maike , Hagemann Vera , Brodowski Lars , von Kaisenberg Constantin 
Published: July 2020

Abstract
Puprose
An emergency caesarean section is a potentially life-threatening situation both for the mother and the newborn. Non-technical skills can be improved by simulation training and are necessary to manage this urgent situation successfully. The objective of this study was to investigate, if training of emergency caesarean section can be transferred into daily work to improve the outcome parameters pH an APGAR of the newborn.

Methods
In this pre-post study, 141 professionals took part in a training for emergency caesarean section. Participants received a questionnaire, based on the tools “Training Evaluation Inventory” and “Transfer Climate Questionnaire” 1 year after training. Outcome data of the newborn were collected from the hospitals information system.

Results
Except the scale “extinction”, Cronbach’s alpha was higher than 0.62. All scales were rated lower than 2.02 on a 5-point Likert Scale (1 = fullest approval; 5 = complete rejection). “Negative reinforcement” was rated with 2.87 (SD 0.73). There were no significant differences in outcome data prior. The questionnaire fulfils criteria for application except the scale “extinction”.

Conclusion
The presented training course was perceived as useful by the professionals and attitudes toward training were positive; the content was positively reinforced in practice 1 year after training. Parameters of the newborn did not change. It is conceivable that other outcome parameters (e.g. posttraumatic stress disorder) are addressed by the training. The development of relevant outcome parameters for the quality of emergency sections needs further investigation.
Evaluating hearing outcome, recidivism and complications in cholesteatoma surgery using the ChOLE classification system
Authors: Bächinger David , Rrahmani Adrian , Weiss Nora M. , Mlynski Robert , Huber Alexander , Röösli Christof 
Published: July 2020

Abstract
Purpose
To establish a standardized reporting system of cholesteatoma, the ChOLE classification has recently been introduced. We here aimed to systematically investigate the association between the ChOLE classification and (i) hearing, (ii) recidivism rate, and (iii) postoperative complications. These data may increase the utility of the ChOLE classification in clinical practice and research by stratifying patients according to expected outcomes or risks for complications.

Methods
In this prospective multicentric study, we included adult patients undergoing tympanomastoid surgery due to cholesteatoma. Main outcome measures included the association of the ChOLE classification system with (i) audiometric data including air conduction (AC) and bone conduction (BC) pure-tone average (PTA), and the air–bone gap (ABG), (ii) recidivism and complication.

Results
A total of 160 patients suffering from cholesteatoma were included. ChOLE stage distribution was stage I in 23 (14%), stage II in 128 (80%), and stage III in 9 (6%) patients. The ChOLE stage was associated with the postoperative AC PTA (p = 0.05) and the postoperative BC PTA (p = 0.02). Further, the status of the ossicular chain after surgery (ChOLE subdivision “O”) was associated with both the postoperative ABG (p = 0.0001) and the postoperative AC PTA (p = 0.003). Moreover, we found an association between complications (ChOLE subdivision “L) and both the postoperative BC PTA (p = 0.04) and the postoperative ABG (p = 0.04). No association between the ChOLE stage was found to both cholesteatoma recidivism and surgical complications.

Conclusion
The ChOLE classification is a new system to classify cholesteatomas. We provide evidence that hearing outcomes vary among different ChOLE stages. In particular, hearing outcomes are associated with the ChOLE subdivision “O” and “L”. Thus, the ChOLE classification system has a predictive value regarding hearing outcomes.
Combined antisaccade task and transcranial direct current stimulation to increase response inhibition in binge eating disorder
Authors: Max Sebastian M. , Plewnia Christian , Zipfel Stephan , Giel Katrin E. , Schag Kathrin 
Published: July 2020

AbstractBinge eating disorder (BED) is associated with deficient response inhibition. Malfunctioning response inhibition is linked to hypoactivation of the dorsolateral prefrontal cortex (dlPFC), where excitability could be increased by anodal transcranial direct current stimulation (tDCS). Response inhibition can be assessed using an antisaccade task which requires supressing a dominant response (i.e. saccade) towards a newly appearing picture in the visual field. We performed a double-blind, randomised, placebo-controlled proof-of-concept-study in which we combined a food-modified antisaccade task with tDCS in people with BED. We expected task learning and modulatory tDCS effects. Sixteen people were allocated to a 1 mA condition, 15 people to a 2 mA condition. Each participant underwent the food-modified antisaccade task at three measurement points: baseline without stimulation, anodal verum and sham stimulation at the right dlPFC in a crossover design. The error rate and the latencies of correct antisaccades decreased over time. No tDCS effect on the error rate could be observed. Compared to sham stimulation, 2 mA tDCS decreased the latencies of correct antisaccades, whereas 1 mA tDCS increased it. Self-reported binge eating episodes were reduced in the 2 mA condition, while there was no change in the 1 mA condition. Participants demonstrated increased response inhibition capacities by a task learning effect concerning the error rate and latencies of correct antisaccades over time as well as a nonlinear tDCS effect represented by ameliorated latencies in the 2 mA and impaired latencies in the 1 mA condition. The reduction of binge eating episodes might indicate a transfer effect to everyday life. Given that the reduction in binge eating was observed before tDCS administration, this effect could not be the result of neuromodulation. Randomized clinical trials are needed to fully understand this reduction, and to explore the efficacy of a combined antisaccade and tDCS training for BED.
Sharp force trauma with two katana swords: identifying the murder weapon by comparing tool marks on the skull bone
Authors: Weber Matthias , Banaschak Sibylle , Rothschild Markus Alexander 
Published: July 2020

AbstractThis paper describes the variety of information that a tool mark analysis on human tissue can provide based on a case of multiple sharp violence. The perpetrator attacked the victim with a sharp-edged weapon against the head, leaving several deep wounds on the back of the skull bone. Three of those marks on the skull bone could be used for a forensic tool mark examination. Silicone casts of the marks were compared by light microscopy with casts of test marks of Japanese katana swords found at the crime scene. One of the swords could be identified as the one responsible for the marks. In addition, the marks and the test marks were scanned in 3D and examined in a visual on-screen comparison confirming the results from the light microscopic examination. Furthermore, a mathematical approach in which the signatures of the marks from the skull bone and the test marks from the sword were compared by cross correlation confirms those findings. In addition, the aforementioned results were used to determine the orientation of the sword in relation to the cranial bone at the time of the respective impact.