bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Hsa_circ_0104824 as a Potential Biomarkers for Breast Cancer
Authors: Li Xiaohan , Ma Fang , Wu Ligang , Zhang Xu , Tian Jinhai , Li Jinping , Cao Jia , Ma Yunfei , Zhang Liang , Wang Libin 
Published: October 2020

Background: To study the specific expression of circular RNA (circRNA) in breast cancer and adjacent normal tissues to identify differentially expressed circRNA in breast cancer patients. To study the correlation between circRNA and clinical data of breast cancer, and to evaluate its potential as a breast cancer biomarker. Methods: The differential expression of circRNAs between the breast cancer tissues and adjacent normal tissues was screened by Human CircRNA Microarray. Candidate circRNAs verified by qRT-PCR. CircRNA was analyzed by Agilent GeneSpring 13.0 software. SPSS23.0, GraphPad Prism, and Sigmaplot software were used for statistical analysis. Perform T test, one-way ANOVA, curve regression analysis and ROC curve analysis for evaluating the diagnostic value of circular RNA. Results: Among the 2021 differentially expressed circRNAs, 546 were up-regulated and 1475 were down-regulated in breast cancer tissues. The validation study demonstrated that six circRNAs were downregulated. Among them, hsa_circ_0104824 proved high correlation between breast cancer tissues and plasma samples in its expression and diagnostic value. Conclusion: Hsa_circ_0104824 may serve as a promising predictive biomarker and therapeutic target for patients with breast cancer.
Outcomes of Type II Endoleak Treatment Using Ethylene Vinyl Alcohol Copolymer (OnyxTM)
Authors: Nuckles Brandon , Nadal Luis , Berger Andrea , Salzler Gregory , Elmore James R. , Ryer Evan J. 
Published: October 2020

Introduction: This study reports our experience with the use of an ethylene vinyl alcohol copolymer (Onyx™) for the treatment of type II endoleak after endovascular repair of abdominal aortic aneurysms (EVAR) in comparison to coils and cyanoacrylate glue. Methods: Clinical data of all patients treated for type II endoleak following EVAR between 2009 and 2017 were retrospectively analyzed. Abdominal aortic aneurysm (AAA) diameter and AAA sac volume during follow-up were measured using computed tomography angiography (CTA). Treatment failure variables were created for the change in sac diameter and volume. An increase in sac diameter ≥ 5 mm was considered a failure, as was an increase ≥ 10% in AAA sac volume. Results: 35 patients underwent treatment for a persistent type II endoleak following EVAR. Of these patients, 18 (51.4%) were treated with Onyx and 17 (48.6%) were treated with coils ± cyanoacrylate glue embolization. There were no significant differences between the 2 groups with regard to demographics. The average volume of Onyx used per treatment was 13.4 ml (range 4.5 ml- 39 ml). There was no difference in efficacy between the Onyx and non-Onyx group. Complications were limited to 1 non-target embolization without significant clinical sequelae. Conclusions: Ethylene vinyl alcohol copolymer (Onyx™) embolization is similarly effective compared to traditional cyanoacrylate glue or coil embolization in the treatment of type II endoleak after EVAR.
Predictors of diabetes distress among older persons with type 2 diabetes mellitus in Indonesia
Authors: Ischaq Nabil Asshiddiqi M , Yodchai Kantaporn , Taniwattananon Ploenpit 
Published: October 2020

Background Older persons living with diabetes have an obligation to change their daily lifestyle, which may contribute to diabetes distress. Furthermore, predictive factors of diabetes distress in older persons might be different from other age groups due to age-related factors. Aims The purpose of the study was to examine the predictive factors of diabetes distress in older persons diagnosed with type 2 diabetes mellitus (T2DM) in Indonesia. Methods A cross-sectional design was used in this study. Participants were recruited from an outpatient department of a tertiary hospital in Klaten City, Central Java, Indonesia. Data were analysed using multiple linear regression with a stepwise method. Results A total 198 older persons were included in the study. The study demonstrated self-efficacy (β = −0.298, P < 0.01), spirituality (β = −0.139, P < 0.05), blood glucose (β = 0.134, P < 0.05), and non-supportive family behaviour (β = 0.135, P < 0.05) as the variables that could statistically predict diabetes distress in older persons with T2DM. Conclusions Self-efficacy is the strongest predictor of diabetes distress. Moreover, the findings can be used as evidence to guide identification and future management of diabetes distress among older persons with T2DM.
Clinical characteristics of the pregnancies and deliveries of patients with moyamoya disease: A single-center analysis over three decades
Authors: Aoyama Jiro , Nariai Tadashi , Moriyama Kurumi , Hara Shoko , Mukawa Maki , Inaji Motoki , Tanaka Yoji , Miyasaka Naoyuki , Taketoshi Maehara  
Published: October 2020

Background and aims As moyamoya disease in pregnancy is clinically rare, it is poorly understood. We therefore analyzed our experiences of moyamoya disease pregnancies and deliveries over three decades. Methods The clinical data of 78 pregnancies and 77 deliveries among 62 moyamoya disease cases at Tokyo Medical and Dental University Hospital from 1991 to 2019 were retrospectively reviewed. Results There were six, 17 and 55 pregnancies in the first, second, and last decades, respectively. The mean patient age at delivery was 29.3 ± 5.0 years. The primary symptoms of moyamoya disease at diagnosis were ischemia in 50 cases (64.1%) and intracranial hemorrhage in eight cases (10.2%). Cesarean section was performed in 75 cases (96.2%). Fifteen pregnancies (19.2%) developed hypertensive disorders of pregnancy; of these, 13 (86.7%) developed hypertensive disorders of pregnancy after 34 weeks of gestation and 9 (60%) required emergency cesarean section because of a sudden increase in blood pressure. Four (5.1%) women experienced renal artery stenosis complications and three of them developed hypertension during pregnancy. Two (2.6%) experienced cerebral infarctions several days after delivery, both of whom had no subsequent aftereffects. No cases of hemorrhagic stroke were reported in the peripartum period. Conclusions To date, this is the largest single-center analysis. It showed the number of moyamoya disease pregnancies has risen rapidly over the last decade. The hypertensive disorders of pregnancy and emergency cesarean section rates were high among moyamoya disease patients. Minor ischemic stroke was observed, but its prevalence was low. Therefore, pregnant women with moyamoya disease should be managed with the understanding that hypertensive disorders of pregnancy is a common complication.
Does Graft Position Affect Subsidence After Anterior Cervical Discectomy and Fusion?
Authors: Jang Hyun-Jun , Chin Dong-Kyu , Kim Kyung-Hyun , Park Jeong-Yoon 
Published: October 2020

Study Design: Retrospective cohort study. Objective: Implant subsidence is an important prognostic factor after anterior cervical discectomy and fusion (ACDF). Our purpose in this study was to investigate whether graft position affects subsidence after ACDF and to determine if there is a difference in clinical results based on allograft subsidence and position. Methods: We reviewed 92 patients who underwent single-level ACDF with allograft and plate between January 2012 and October 2018. Treatment levels were divided based on allograft position within 2 mm of the posterior margin of the augmented plate (Anterior group) or at greater than 2 mm (Center group). Subsidence was defined as segmental vertebral body height decrease of 2 mm or more at 1 year compared to 1 week after surgery. Results: Overall subsidence prevalence was 15 (16%) cases. Subsidence was 11% in the Anterior group (8/73) and 39% in the Center group (7/19; P = .012). The subsidence group showed smaller graft footprint size (graft/endplate ratio) compared with the nonsubsidence group, and pseudarthrosis occurred frequently in the subsidence. There was no significant difference in clinical results according to graft position. These findings indicate that anterior graft position reduces risk of subsidence (95% confidence interval = 0.085-0.949). Conclusion: To minimize risk of subsidence, the graft should be positioned on the anterior position of the surgical-level endplate. In addition, using a graft appropriate for endplate size will further reduce subsidence.
Die Personalabteilung als Wertschöpfungs-Center
Authors: Wunderer Rolf , Schlagenhaufer Peter 
Published: October 2020

“Wertschöpfung” bezeichnet die Differenz zwischen den Output an betrieblich geschaffenen Gütem und/oder Dienstleistungen und den sämtliche Vorleistungen umfassenden Input. In seiner Übertragung auf die betriebliche Personalarbeit bezieht sich die Wertschöpfung auf die Dienstleistungen für die wesentlichen internen und extemen Bezugsgruppen und ermöglicht dem Personalwesen, innerbetrieblich die eigenen Leistungen zu verrechnen. Die Autoren berichten über eine Befragung von 52 Personalleitern unterschiedlich großer Unternehmen zu den Aufgaben der Personalarbeit, zu ihrer Beurteilung des Wertschöpfung-Center-Ansatzes und zu Aspekten des Personal-Controllings.
Surgical Technique for Management of Severe Calcaneofibular Impingement: Case Series
Authors: Levin Jay M. , DeOrio James K. 
Published: October 2020

Background: Calcaneofibular impingement is characterized by lateral hindfoot pain and is commonly resulting from calcaneal fracture malunion or severe flatfoot deformity. Lateral calcaneal wall decompression has been used successfully to relieve pain in patients who have calcaneofibular impingement. However, in cases of severe impingement and hindfoot valgus, lateral wall excision may leave only a small remnant of calcaneal bone for weightbearing and can lead to chronic heel pain. We describe a surgical technique using a medial displacement calcaneal osteotomy (MDCO) combined with a lateral wall exostectomy and report on the outcomes from our series of patients. Methods: Retrospective study of a single surgeon’s patients was done from 2010 to 2020 who underwent medial slide calcaneal osteotomy and lateral wall exostectomy for calcaneofibular impingement. Descriptive statistics were used to summarize patient characteristics. Our study included 9 patients, 6 females and 3 males, with a mean age of 59 years (range: 19-77) and a mean follow-up of 62 weeks (range: 6-184). Results: Five had an Achilles split approach, 2 had an oblique lateral approach, and 1 had an extensile lateral approach. Patients achieved radiographic relief of impingement and improvement in pain. Minor skin and soft tissue complications occurred in 3 patients, all of which were associated with laterally based incisions, and all resolved after a 10-day course of oral antibiotics. No major complications, emergency department visits, or readmissions occurred. Conclusions: MDCO and lateral wall exostectomy was a safe and effective treatment for severe calcaneofibular impingement. Level of Evidence: Level IV, retrospective case series.
A Cross-Sectional Study Analyzing the Quality of YouTube Videos as a Source of Patient Education for Treatments on Psoriasis
Authors: Gorrepati Pavane L. , Smith Gideon P. 
Published: October 2020

Background: YouTube is currently the second most popular website in the world, with over 1 billion hours watched each day. Unlike peer-reviewed journals, there is no process to ensure the quality of YouTube videos that cover medical and treatment information, which could lead to patient misinformation. Objective: We set out to use the DISCERN instrument, which has previously been used in studies to assess the quality of consumer health information regarding treatment choices, to systematically evaluate the quality of the information. Methods: A YouTube search was performed on April 12, 2020, using the keyword “psoriasis treatments.” Since 90% of YouTube users do not view past the first 30 videos, only the first 30 results were selected. Non-English videos, advertisements, and videos that were too specific for the search criteria entered were excluded. Results: The average total DISCERN score was 38.3, which categorizes the videos overall as “poor” quality of content. There was a statistically significant difference in total DISCERN scores between the videos created by patients and those created by hospital/physician sources ( P < .015), with hospital-/physician-made videos scoring higher. However, regardless of the source of the video, there were still significant shortcomings in all the videos assessed. Conclusion: We feel we have a responsibility and an opportunity as a specialty to provide high-quality information, with a specific focus on the areas identified by the DISCERN tool as lacking, to help guide patients on evidence-based therapeutic options.
Cost comparison of different treatment approaches of dacryocystitis and dacrocystocele
Authors: Sieck Erin G. , Zukin Leonid , Patnaik Jennifer L. , Lynch Anne M. , Kelley Peggy , Singh Jasleen K. 
Published: October 2020

Purpose: Congenital dacrocystocele with potential for dacryocystitis are common ophthalmic findings in children. There are multiple surgical approaches to open the mucocele. In this study, we look at the financial impact of these different approaches. Methods: A retrospective chart review of 17 patients with dacrocystocele or dacryocystitis was performed. We examined four approaches: (1) bedside nasal endoscopy with marsupialization of nasolacrimal duct (NLD) cyst, (2) surgically performed nasal endoscopy with marsupialization of NLD cyst, (3) NLD probe, and (4) a combination of procedures. Cost of the procedure and length of anesthesia were collected. Reoccurrence of symptoms and disease post-procedure were also collected. Results: The lowest cost billed procedure was bedside nasal endoscopy performed by an otolaryngologist (US$435; n = 1). A nasal endoscopy ( n = 2) performed in the operating room (OR) had an average OR fee of US$14,557 [standard deviation (SD): US$7598] for 108.5 (SD: 87.0) min of operating time. An NLD probe ( n = 5) performed by pediatric ophthalmologists resulted in an average OR fee of US$5540 (SD: US$1752) for 31.0 min (SD: 8.6 min) of operating time. A combination of both nasal endoscopy and NLD probing ( n = 9) had an average OR fee US$10,325 (SD: US$4137) for 69 min (SD: 34.5 min) of operating time. Conclusion: This is the first study looking at cost benefit of four different approaches to treating dacrocystoceles/dacryocystitis. A NLD probe was a low-cost OR intervention and had the shortest operating time. The combination procedure was more cost-effective than nasal endoscopy or NLD probing alone.
Psycho-social correlates of leisure-time physical activity (LTPA) among older adults: a multivariate analysis
Authors: Lee Sunwoo , Lee Chungsup , An Jaesung 
Published: October 2020

Abstract
Background
Still, a considerable number of older adults hardly meet the daily physical activity recommendation. The current study examined how the elderly’s attitudinal and perceptional aspects were associated with their Leisure-Time Physical Activity (LTPA) participation in order to provide insight into the physical activity promotion.

Methods
Study used a total sample of 10,700 older adults aged 65+ drawn from the Health and Retirement Study (HRS) 2014–2015 in USA. Multiple questionnaire items were employed to assess older adults’ attitudes and outlook across different life domains. LTPA participation was measured using two indicators—walking and sports/exercise. A technique of adjusted multivariate analysis was employed to examine the relationships between predictors and outcome variables.

Results
Results indicated that psychosocial indicators were significantly associated with older adults’ LTPA: self-perception of ageing, self-efficacy, intrinsic motivation, spiritual engagement, perceived social tie and neighbourhood safety; while measures of perceived social relations and neighbourhood safety demonstrated different associations with walking and sports/exercise on its intensity.

Conclusions
Health professionals should be well-informed about psychosocial roles, either as facilitators or constraints, in older adults’ physical activity participation. Incorporation of psychosocial intervention into physical activity promotion can help older adults develop positive attitudes and inner strength linked to their health behaviour.
Primary care in the time of COVID-19: monitoring the effect of the pandemic and the lockdown measures on 34 quality of care indicators calculated for 288 primary care practices covering about 6 million people in Catalonia
Authors: Coma Ermengol , Mora Núria , Méndez Leonardo , Benítez Mència , Hermosilla Eduardo , Fàbregas Mireia , Fina Francesc , Mercadé Albert , Flayeh Souhel , Guiriguet Carolina , Balló Elisabet , Martinez Leon Nuria , Mas Ariadna , Cordomí Sílvia , Lejardi Yolanda , Medina Manuel 
Published: October 2020

Abstract
Background
To analyse the impact of the COVID-19 epidemic and the lockdown measures on the follow-up and control of chronic diseases in primary care.

Methods
Retrospective study in 288 primary care practices (PCP) of the Catalan Institute of Health. We analysed the results of 34 indicators of the Healthcare quality standard (EQA), comprising different types: treatment (4), follow-up (5), control (10), screening (7), vaccinations (4) and quaternary prevention (4). For each PCP, we calculated each indicator’s percentage of change in February, March and April 2020 respective to the results of the previous month; and used the T-Student test for paired data to compare them with the percentage of change in the same month of the previous year. We defined indicators with a negative effect those with a greater negative change or a lesser positive change in 2020 in comparison to 2019; and indicators with a positive effect those with a greater positive change or a lesser negative change.

Results
We observed a negative effect on 85% of the EQA indicators in March and 68% in April. 90% of the control indicators had a negative effect, highlighting the control of LDL cholesterol with a reduction of − 2.69% (95%CI − 3.17% to − 2.23%) in March and − 3.41% (95%CI − 3.82% to − 3.01%) in April; and the control of blood pressure with a reduction of − 2.13% (95%CI − 2.34% to − 1.9%) and − 2.59% (95%CI − 2.8% to − 2.37%). The indicators with the greatest negative effect were those of screening, such as the indicator of diabetic foot screening with a negative effect of − 2.86% (95%CI − 3.33% to − 2.39%) and − 4.13% (95%CI − 4.55% to − 3.71%) in March and April, respectively. Only one vaccination indicator, adult Measles-Mumps-Rubella vaccine, had a negative effect in both months. Finally, among the indicators of quaternary prevention, we observed negative effects in March and April although in that case a lower inadequacy that means better clinical outcome.

Conclusions
The COVID-19 epidemic and the lockdown measures have significantly reduced the results of the follow-up, control, screening and vaccination indicators for patients in primary care. On the other hand, the indicators for quaternary prevention have been strengthened and their results have improved.
Ultrasound to address medullary sponge kidney: a retrospective study
Authors: Pisani Isabella , Giacosa Roberto , Giuliotti Sara , Moretto Dario , Regolisti Giuseppe , Cantarelli Chiara , Vaglio Augusto , Fiaccadori Enrico , Manenti Lucio 
Published: October 2020

Abstract
Background
Medullary sponge kidney (MSK) is a rare disease characterized by cystic dilatation of papillary collecting ducts. Intravenous urography is still considered the gold standard for diagnosis. We identified a cohort of patients from our outpatient clinic with established diagnosis of MSK to outline some ultrasonographic characteristics that may help establish a diagnosis.

Methods
We conducted a retrospective study of patients seen between January 1st 2009 and January 1st 2019 in our clinic. Out of 4321 patients, 18 had a diagnosis of MSK. We reviewed their clinical and family history, laboratory data and imaging studies. Specifically, we focused on ultrasound imaging.

Results
Patients were referred to our outpatient clinic because of renal impairment (44%), family history of nephropathy (17%), nephrolithiasis or an established diagnosis of MSK (39%). Seventy-two percent of patients presented with chronic kidney disease, 22% required hemodialysis. Urinary tract infections (44%), nephrolithiasis (33%), microscopic hematuria (50%) and proteinuria (44%) were reported. Seven patients underwent computed tomography; all of them received ultrasound. Ultrasound examination showed bilateral renal cysts, usually small and located in the renal medulla, and microcalcifications located in the medulla or within the cysts.

Conclusion
We identified a peculiar tetrad associated with MSK: 1) hypoechoic medullary areas, 2) hyperechoic spots, 3) microcystic dilatation of papillary zone, 4) multiple calcifications (linear, small stones or calcified intracystic sediment) in each papilla. The presence of this diagnostic tetrad, added to laboratory data and clinical history, could be helpful in the differential diagnosis to identify patients with MSK.
A nomogram for predicting survival in patients with de novo metastatic breast cancer: a population-based study
Authors: Zhao Wen , Wu Lei , Zhao Andi , Zhang Mi , Tian Qi , Shen Yanwei , Wang Fan , Wang Biyuan , Wang Le , Chen Ling , Zhao Xiaoai , Dong Danfeng , Zhang Lingxiao , Yang Jin 
Published: October 2020

Abstract
Background
5–10% of patients are diagnosed with metastatic breast cancer (MBC) at the initial diagnosis. This study aimed to develop a nomogram to predict the overall survival (OS) of these patients.

Methods
de novo MBC patients diagnosed in 2010–2016 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. They were randomly divided into a training and a validation cohort with a ratio of 2:1. The best subsets of covariates were identified to develop a nomogram predicting OS based on the smallest Akaike Information Criterion (AIC) value in the multivariate Cox models. The discrimination and calibration of the nomogram were evaluated using the Concordance index, the area under the time-dependent receiver operating characteristic curve (AUC) and calibration curves.

Results
In this study, we included 7986 patients with de novo MBC. The median follow-up time was 36 months (range: 0–83 months). Five thousand three-hundred twenty four patients were allocated into the training cohort while 2662 were allocated into the validation cohort. In the training cohort, age at diagnosis, race, marital status, differentiation grade, subtype, T stage, bone metastasis, brain metastasis, liver metastasis, lung metastasis, surgery and chemotherapy were selected to create the nomogram estimating the 1-, 3- and 5- year OS based on the smallest AIC value in the multivariate Cox models. The nomogram achieved a Concordance index of 0.723 (95% CI, 0.713–0.733) in the training cohort and 0.719 (95% CI, 0.705–0.734) in the validation cohort. AUC values of the nomogram indicated good specificity and sensitivity in the training and validation cohort. Calibration curves showed a favorable consistency between the predicted and actual survival probabilities.

Conclusion
The developed nomogram reliably predicted OS in patients with de novo MBC and presented a favorable discrimination ability. While further validation is needed, this may be a useful tool in clinical practice.