bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peak blood pressure‐guided monitoring may serve as an effective approach for blood pressure control in the out‐of‐office setting
Authors: Gong Shenzhen , Xu Ying , Ye Runyu , Liu Kai , Li Jiangbo , Yang Changqiang , Yan Xin , Chen Xiaoping 
Published: October 2020

AbstractWe aimed to explore whether diurnal blood pressure (BP) peak characteristics have a significant influence on the association between left ventricular damage with the two BP components (morning BP vs. afternoon peak BP) in untreated hypertensives. This cross‐sectional study included 1084 hypertensives who underwent echocardiography and 24‐h ambulatory BP monitoring. Participants were stratified according to the relationship between morning systolic BP (MSBP; average SBP within 2 h of waking up) and afternoon peak systolic BP (ASBP; average SBP between 16:00 and 18:00). Afternoon and morning hypertension was defined as ≥ 135/85 mm Hg. The morning and afternoon peak BPs occurred at around 7:00 and 17:00, respectively. In general hypertensives, morning BP and afternoon peak BP are significantly different in absolute values (for binary SBP, McNemar's χ2 = 6.42; p = .014). ASBP was more pronounced than MSBP in 602 patients (55.5%), in whom 24‐h SBP showed higher consistency with ASBP than with MSBP (Kappa value: 0.767 vs 0.646, both p < .01). In subjects with ASBP ≥ MSBP, ASBP was associated with left ventricular hypertrophy independent of MSBP (logistic regression analysis odds ratio: 1.046, p < .01), and left ventricular mass index was more strongly correlated with ASBP than with MSBP (multiple regression coefficient β: 0.453, p < .01), in which the relationships held true independently of 24‐h SBP. The opposite results were obtained in subjects with MSBP > ASBP. Peak BP‐guided monitoring may serve as an effective approach to out‐of‐office hypertension monitoring and control, providing the best consistency with 24‐h average SBP and highest discrimination performance for target organ damage, independently of 24‐h SBP.
Resolvin D1 attenuates the inflammatory process in mouse model of LPS‐induced keratitis
Authors: Petrillo Francesco , Trotta Maria Consiglia , Bucolo Claudio , Hermenean Anca , Petrillo Arianna , Maisto Rosa , Pieretti Gorizio , Pietropaolo Michela , Ferraraccio Franca , Gagliano Caterina , Galdiero Marilena , D'Amico Michele 
Published: October 2020

AbstractThe aim of this study was to investigate the effects of the lipid mediator Resolvin D1 in experimental keratitis. C57BL/6J mice were injected with lipopolysaccharide (2 µg/eye), and after 24 hours, the corneal damage was assessed. Clinical score was quantified, and corneal inflammatory biomarkers were detected by immunohistochemistry. A robust accumulation of sub‐epithelial macrophages and polymorphonuclear leucocytes, chemokine (C‐X‐C motif) ligand 1 (also known as keratinocyte‐derived chemokine), interleukin‐10 and promoters of apoptosis was also observed in lipopolysaccharide‐treated mice. Formyl peptide receptor 2 corneal expression was also assessed. The corneal stroma treated with lipopolysaccharide was characterized by presence of macrophages of M1‐like subtype and immature fibroblastic cells, marked with Ki67, not fully differentiated in fibroblasts. Indeed, the staining of the cornea with anti‐vimentin antibodies, a marker of differentiated myofibroblasts, was very faint. Resolvin D1 attenuated all the inflammatory parameters assessed in the present study, except for IL‐10. In conclusion, the data presented here seem to be consistent with the hypothesis that Resolvin D1 protected the cornea from the lipopolysaccharide‐induced keratitis by acting on several inflammatory components of this damage, pivoted by Formyl peptide receptor 2 (FPR2) activation and macrophages‐leucocytes activity.
Cannabidiol (CBD) modulation of apelin in acute respiratory distress syndrome
Authors: Salles Évila Lopes , Khodadadi Hesam , Jarrahi Abbas , Ahluwalia Meenakshi , Paffaro Valdemar Antonio , Costigliola Vincenzo , Yu Jack C. , Hess David C. , Dhandapani Krishnan M. , Baban Babak 
Published: October 2020

AbstractConsidering lack of target‐specific antiviral treatment and vaccination for COVID‐19, it is absolutely exigent to have an effective therapeutic modality to reduce hospitalization and mortality rate as well as to improve COVID‐19‐infected patient outcomes. In a follow‐up study to our recent findings indicating the potential of Cannabidiol (CBD) in the treatment of acute respiratory distress syndrome (ARDS), here we show for the first time that CBD may ameliorate the symptoms of ARDS through up‐regulation of apelin, a peptide with significant role in the central and peripheral regulation of immunity, CNS, metabolic and cardiovascular system. By administering intranasal Poly (I:C), a synthetic viral dsRNA, while we were able to mimic the symptoms of ARDS in a murine model, interestingly, there was a significant decrease in the expression of apelin in both blood and lung tissues. CBD treatment was able to reverse the symptoms of ARDS towards a normal level. Importantly, CBD treatment increased the apelin expression significantly, suggesting a potential crosstalk between apelinergic system and CBD may be the therapeutic target in the treatment of inflammatory diseases such as COVID‐19 and many other pathologic conditions.
Association of time in range with hemoglobin A1c, glycated albumin and 1,5‐anhydro‐d‐glucitol
Authors: Ohigashi Mana , Osugi Keiko , Kusunoki Yoshiki , Washio Kahori , Matsutani Satoshi , Tsunoda Taku , Matsuo Toshihiro , Konishi Kosuke , Katsuno Tomoyuki , Namba Mitsuyoshi , Koyama Hidenori 
Published: October 2020

AbstractAims/IntroductionHemoglobin A1c (HbA1c), glycated albumin (GA) and 1,5‐anhydro‐d‐glucitol (1,5‐AG) are used as indicators of glycemic control, whereas continuous glucose monitoring (CGM) is used to assess daily glucose profiles. The aim of this study was to investigate the relationships between CGM metrics, such as time in range (TIR), and glycemic control indicators.Materials and MethodsWe carried out retrospective CGM and blood tests on 189 outpatients with impaired glucose tolerance (n = 22), type 1 diabetes mellitus (n = 67) or type 2 diabetes mellitus (n = 100).ResultsIn type 1 diabetes mellitus and type 2 diabetes mellitus patients, HbA1c and GA were negatively correlated with TIR, whereas 1,5‐AG was positively correlated with TIR. In type 1 diabetes mellitus patients, a TIR of 70% corresponded to HbA1c, GA and 1,5‐AG of 6.9% (95% confidence interval [CI] 6.5–7.2%), 20.3% (95% CI 19.0–21.7%) and 6.0 µg/mL (95% CI 5.1–6.9 µg/mL), respectively. In type 2 diabetes mellitus patients, a TIR of 70% corresponded to HbA1c, GA and 1,5‐AG of 7.1% (95% CI 7.0–7.3%), 19.3% (95% CI 18.7–19.9%) and 10.0 µg/mL (95% CI 9.0–11.0 µg/mL), respectively. TIR values corresponding to HbA1c levels of 7.0% were 56.1% (95% CI 52.3–59.8%) and 74.2% (95% CI 71.3–77.2%) in type 1 diabetes mellitus and type 2 diabetes mellitus patients, respectively.ConclusionsThe results of this study showed that the estimated HbA1c corresponding to a TIR of 70% was approximately 7.0% for both type 1 diabetes mellitus and type 2 diabetes mellitus patients, and that the estimated 1,5‐AG calculated from the TIR of 70% might be different between type 1 diabetes mellitus and type 2 diabetes mellitus patients.
IgE autoantibodies in serum and skin of non‐bullous and bullous pemphigoid patients
Authors: Lamberts A. , Kotnik N. , Diercks G.F.H. , Meijer J.M. , Di Zenzo G. , Pas H.H. , Jonkman M.F. , Gibbs B.F. , Raap U. , Horváth B. 
Published: October 2020

AbstractBackgroundNon‐bullous pemphigoid (NBP) is a pemphigoid variant which frequently resembles other pruritic skin diseases. In contrast with bullous pemphigoid (BP), blisters are absent. In BP, previous studies showed that IgE autoantibodies may be involved in its pathogenesis. IgE‐activated mast cells, basophils and eosinophils may participate in BP by inducing pruritus and possibly blister formation, although the differential role of IgE in NBP compared with BP has not yet been described.ObjectiveTo assess IgE in serum and skin of NBP and BP patients.MethodsWe examined total IgE and pemphigoid‐specific IgE in the serum of 68 NBP and 50 BP patients by enzyme‐linked immunosorbent assay (ELISA). Sera of 25 pemphigus patients and 25 elderly patients with pruritus were included as controls. Skin biopsies of 14 NBP and 14 BP patients with the highest IgE titres to NC16A were stained for IgE by immunofluorescence techniques.ResultsTotal IgE was elevated in 63% of NBP and 60% of BP patients, and in 20% of pemphigus controls, as well as 60% of elderly controls. IgE ELISAs were more frequently positive in BP than in NBP (NC16A 18% vs. 9%, P = 0.139; BP230 34% vs. 22%, P = 0.149). IgE ELISAs for NC16A and BP230 were positive in 8% and 20% of elderly controls, respectively, while all pemphigus controls were negative. Two of 28 biopsies (7%; one NBP, one BP) showed linear IgE along the basement membrane zone, while in most biopsies (71% NBP; 86% BP) IgE was bound to dermal cells.ConclusionSince IgE was present in the serum and skin of both NBP and BP patients, this supports IgE‐dependent mechanisms common to both diseases, such as pruritus. However, it remains to be elucidated whether IgE contributes to blister formation in BP.
Observations of coastal aggregations of the broadnose sevengill shark (Notorynchus cepedianus) in Chilean waters
Authors: Bustamante Carlos , García‐Cegarra Ana M. , Vargas‐Caro Carolina 
Published: October 2020

AbstractThe presence of four sharks was documented in coastal waters of Antofagasta (Chile) using an unmanned aerial video camera. Fishers took advantage of this aggregation to catch and sold three adult broadnose sevengill sharks Notorynchus cepedianus. Species identity was determined by using the cox1 gene. One additional video was later recorded 3000 km south of Antofagasta, and shows a large female interacting with a salmon farming facility. Shallow water records of N. cepedianus were previously undocumented in Chilean waters, yet historically have provided an opportunistic event to fishers in Chile.
Hydrogen sulfide, a signaling molecule in plant stress responses
Authors: Zhang Jing , Zhou Mingjian , Zhou Heng , Zhao Didi , Gotor Cecilia , Romero Luis C. , Shen Jie , Ge Zhenglin , Zhang Zhirong , Shen Wenbiao , Yuan Xingxing , Xie Yanjie 
Published: October 2020

AbstractGaseous molecules, such as hydrogen sulfide (H2S) and nitric oxide (NO), are crucial players in cellular and (patho)physiological processes in biological systems. The biological functions of these gaseous molecules, which were first discovered and identified as gasotransmitters in animals, have received unprecedented attention from plant scientists in recent decades. Researchers have arrived at the consensus that H2S is synthesized endogenously and serves as a signaling molecule throughout the plant life cycle. However, the mechanisms of H2S action in redox biology is still largely unexplored. This review highlights what we currently know about the characteristics and biosynthesis of H2S in plants. Additionally, we summarize the role of H2S in plant resistance to abiotic stress. Moreover, we propose and discuss possible redox‐dependent mechanisms by which H2S regulates plant physiology.
Reliable change in neuropsychological test scores is associated with brain atrophy in older adults
Authors: Lin Shayne S.‐H. , Fletcher Evan , Gavett Brandon E. ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: October 2020

The reliable change index (RCI) is a commonly used method for interpreting change in neuropsychological test scores over time. However, the RCI is a psychometric method that, to date, has not been validated against neuroanatomical changes. Longitudinal neuroimaging and neuropsychological data from baseline and one‐year follow‐up visits were retrieved from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. The RCI was used to identify participants showing reliable decline on memory (ADNI‐Mem; N = 450) and executive functioning (ADNI‐EF; N = 456) factor scores. For each factor score, two groups (reliable change vs. no reliable change) were matched on potential baseline confounding variables. Longitudinal neuroanatomical data were analysed using tensor‐based morphometry. Analysis revealed that reliable change on ADNI‐Mem was associated with atrophy in the medial temporal cortex, limbic cortex, temporal lobe and some regions of the parietal lobe. Similar atrophy patterns were found for reliable change on ADNI‐EF, except that atrophy extended to the frontal lobe and the atrophy was more extensive and of higher magnitude. The current study not only validates clinical usage of the RCI with neuroanatomical evidence of associated underlying brain change but also suggests patterns of likely brain atrophy when reliable cognitive decline is detected.
A qualitative study of long‐term ICU patients' inner strength and willpower: Family and health professionals as a health‐promoting resource
Authors: Alexandersen Ingeborg , Haugdahl Hege S. , Paulsby Tove Engan , Lund Stine Borgen , Stjern Berit , Eide Regina , Haugan Gørill 
Published: October 2020

AbstractAims and objectivesTo explore how the presence of family and health professionals influences long‐term critically ill patients' inner strength and willpower as an incitement to keep fighting for recovery.BackgroundThis study reports long‐term critically ill patients' experiences of family and health professionals as health‐promoting resources in terms of significance for their inner strength and willpower. Earlier research on this topic is scarce.DesignA qualitative, hermeneutic‐phenomenological approach, within the context of Antonovsky's salutogenic theory.MethodsSeventeen long‐term critically ill patients were interviewed once, at 6–18 months after ICU discharge. The consolidated criteria for reporting qualitative research (COREQ) were used (Supplementary File 1).ResultsFour main themes identified how family and staff promoted and challenged the patient's inner strength and willpower: (a) the importance of family and friends; my family was surrounding me, (b) staff contributions, (c) challenges to inner strength and willpower in relation to family and (d) loneliness and indifferent care.ConclusionThis study brings new knowledge from the long‐term critically ill patient's view about the impact of family, friends and nurses on the patient's inner strength and willpower. All impact is experienced positively and negatively.Relevance to clinical practiceKnowledge from the long‐term critically ill patient's view is vital in nurse–patient interactions to facilitate liberation of inner strength and willpower.
Validation of a Chinese version of the dementia knowledge assessment scale in healthcare providers in China
Authors: Zhao Yayi , Eccleston Claire E. , Ding Yaping , Shan Ye , Liu Li , Chan Helen Y. L. 
Published: October 2020

AbstractAimsTo translate 25‐item Dementia Knowledge Assessment Scale into Chinese and evaluate its psychometric properties amongst Chinese healthcare providers.BackgroundThe prevalence of dementia is increasing in China, but development of relevant training for healthcare providers is still in its infancy stage. A comprehensive, valid and reliable Chinese knowledge‐of‐dementia measure is needed to identify training needs and evaluate the effect of educational interventions.DesignA cross‐sectional survey.MethodsThe Dementia Knowledge Assessment Scale was translated into Chinese following the modified Brislin's translation model. Content and face validity were established by an expert panel in dementia care and healthcare providers. A convenience sample of 290 healthcare providers in care homes and hospitals was recruited. Construct validity was evaluated through confirmatory factor analysis, concurrent validity and known groups’ comparisons method. Reliability was evaluated through internal consistency reliability and 2‐week test–retest reliability. This study used the STROBE checklist for reporting.ResultsThe content validity index was 0.98. The confirmatory factor analysis model revealed that the four‐factor model was partly supported in the present study. The moderate correlation between Chinese version of Dementia Knowledge Assessment Scale and Alzheimer's Disease Knowledge Scale indicated acceptable concurrent validity. The mean score of the scale and subscale scores showed significant differences between health professionals and care assistants, except for the subscale of “Care Considerations.” The reliability was demonstrated with Cronbach's alpha of .77 and intra‐class correlation coefficients of each subscale between .74 and .92 among 56 respondents.ConclusionsThe Chinese version of Dementia Knowledge Assessment Scale demonstrated acceptable concurrent validity but marginal factorial validity and satisfactory reliability amongst Chinese healthcare providers. Therefore, applying the four‐factor structure of Chinese version scale should be considered.Relevance to clinical practiceChinese version of Dementia Knowledge Assessment Scale can be used to understand the training needs of healthcare providers in dementia.
Correlation between the number of laparoscopy‐qualified gynecologists and the proportion of laparoscopic surgeries for benign gynecological diseases in Japan: An ecological study
Authors: Isobe Masanori , Kataoka Yuki , Chikazawa Kenro , Hada Tomonori , Nishigori Hiroshi , Takahashi Toshifumi , Enomoto Takayuki 
Published: October 2020

AbstractAimWe aimed to evaluate regional disparities in the proportion of the three main laparoscopic surgeries for benign gynecological diseases among 47 prefectures in Japan and their correlation with the number of laparoscopy‐qualified gynecologists per population.MethodsIn this retrospective ecological study, we collected the data of patients from 47 prefectures in 2017 using “The National Database of Health Insurance Claims and Specific Health Checkups of Japan” Open Data from the Ministry of Health, Labor and Welfare in Japan. The primary outcome of the study was the proportion of laparoscopic surgeries conducted for benign gynecologic diseases (hysterectomy, myomectomy and surgery for the benign ovarian diseases). The main exposure was the number of laparoscopy‐qualified gynecologists per 100 000 females.ResultsThe average proportion of laparoscopic hysterectomies, myomectomies and surgeries for the benign ovarian disease were 38% (standard deviation (SD) 16, range 12–74), 48% (SD 18, range 9–81) and 60% (SD 11, range 36–79), respectively. Multiple regression analysis showed a significant correlation between the number of laparoscopy‐qualified gynecologists per 100 000 females and the proportion of the three main laparoscopic surgeries.ConclusionThere are obvious regional disparities in the proportion of the three main laparoscopic procedures for benign gynecological diseases among 47 prefectures. The number of laparoscopy‐qualified gynecologists correlated significantly with these regional disparities. The academic society should monitor these regional disparities and make an effort to reduce these regional disparities by increasing laparoscopy‐qualified gynecologists in areas where the widespread use of laparoscopic techniques is lagging.
A Comparison of Conventionally Versus Digitally Fabricated Denture Outcomes in a University Dental Clinic
Authors: Clark Wendy Auclair , Brazile Briana , Matthews Desi , Solares Jonathan , De Kok Ingeborg J. 
Published: October 2020

AbstractPurposeThe purpose of this retrospective, cross‐sectional study is to evaluate if there is a difference in number of visits (including fabrication and postoperative) and remake rate when comparing conventionally fabricated and digitally fabricated complete dentures by dental students in a predoctoral student dental clinic.Materials and methodsThis two‐year retrospective cross‐sectional study consisted of a chart review for patients receiving maxillary and/or mandibular complete dentures between 2017 and 2019 (n = 314) at the UNC Adams School of Dentistry predoctoral student clinic. No control group was determined for this study. Data were extracted for 242 conventional dentures and 39 digital dentures. Objective treatment outcomes were obtained for each included denture: the number of patient appointments from preliminary impressions to denture placement, the number of postoperative visits, any complications noted, and any need for remakes. Fisher's Exact Test and Cochran‐Mantel‐Haenszel analysis were completed with statistical significance set at p < 0.05.ResultsFor the number of visits from preliminary impression to placement, 50% of conventionally fabricated dentures had 6 or more visits, while only 5% of digitally fabricated dentures had 6 or more visits. This difference for the number of patient visits was statistically significant (p < 0.05). Additionally, conventionally fabricated dentures required an average of 2‐3 postoperative visits, whereas digitally fabricated dentures required 1‐2 postoperative visits. This difference was also statistically significant (p < 0.05). For the number of dentures requiring remake, there was no statistical difference (p = 0.1904).ConclusionsWhen comparing conventionally fabricated and digitally fabricated dentures in the predoctoral clinic, the digitally fabricated dentures required fewer patient appointments from start to finish, and fewer postoperative appointments than conventionally fabricated dentures. Fewer visits may be an important consideration for patients, especially those with limited access to care.
A humeral intracondylar repair system for the management of humeral intracondylar fissure and humeral condylar fracture
Authors: Walton M. B. , Crystal E. , Morrison S. , Onyett J. , McClement J. , Allan R. , Straw M. , Innes J. F. 
Published: October 2020

ObjectivesTo report complications, clinical outcomes and CT‐imaging outcomes of a surgical system designed for the management of humeral intracondylar fissures and humeral condylar fractures.Materials and MethodsRetrospective review of fracture healing from medical records, direct owner contact and an online data‐submission service. Follow‐up included CT scans and a calculated “bone‐opacity continuity index” to quantify bone healing.ResultsThere was one major surgical complication and one major medical complication out of 34 fissure cases, and two major surgical and one major medical complication out of 14 fractures. Follow‐up times ranged from 29 to 1268 days. All cases with CT follow‐up had some continuity of bone opacity across the condyle.Clinical SignificanceIn the cases included in this study, this repair system was associated with low complication rates and favourable healing rates, particularly for humeral intracondylar fissure.