bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Paradox of Contemporary Play: The Dangers of Framing Play
Authors: NOVAK Rene 
Published: May 2020

This paper will elaborate on the different ways play is being framed in the contemporary western world and how framing play is making it susceptible to manipulation that employs it to work in contradiction with its core purposes. The author suggests a contemporary paradox that arises in the core of early childhood education concerning child’s play. As play is a basic developmental function of mind and body common to all mammals, some important functions of play are going to be investigated. Due to the established fact that freedom to exercise play is of the outmost importance for a normal developing mammal from infancy to adulthood, this paper will focus on the reasons as to why people defy nature, by restricting its young in this basic form of activity and engagement, hindering their normal development, and ignoring that play carries vital epistemological and ontological human significance. Commercialisation of play alongside the disappearing time and space for free play in communities, at home, school and ece centres will be accounted for as reasons for an erosion of play, alongside some influential ideologies of play.
Following form this the author investigates how framing play accounts for difficulties in empirical research of play, contributing to a lack of clear pedagogical, phenomenological and methodological answers about play and hence raises questions concerning a need for further phenomenological investigations of play alongside alternative methodological frameworks to ‘see’ beyond the elusiveness of play.
Sensitivity of High-Resolution Computed Tomography in Otosclerosis Patients undergoing Primary Stapedotomy
Authors: Maxwell Anne K. , Shokry Mohamed Hosameldeen , Master Adam , Slattery William H. 
Published: May 2020

Objective: To determine the incidence of abnormal otospongiotic or otosclerotic findings on high-resolution computed tomography (HRCT) as read by local radiologists in patients with surgically-confirmed otosclerosis. Study design: Retrospective chart review. Setting: Tertiary-referral private otology-neurotology practice. Patients: Adults (>18 years old) with surgically-confirmed otosclerosis between 2012 and 2017 with a HRCT performed preoperatively. Intervention: Preoperative HRCT then stapedotomy. Main outcome measures: Positive identification and location of radiographic otosclerosis as reported by the local radiologist. We then correlated the CT with surgical location as documented at time of surgery. Audiometry, demographic data, intraoperative findings, and surgical technique were secondarily reviewed. Results: Of the 708 stapes surgeries were performed during the study time frame. Preoperative HRCT scans were available for 68 primary stapedotomy surgeries performed in 54 patients. Otosclerosis was reported in 20/68 (29.4%). Following a negative report by the local radiologist, a re-review by the surgeon and/or collaborating neuroradiologist confirmed otosclerosis in 12/48 additional cases (25.0%). There was an overall sensitivity of 47.1%. Intraoperatively, cases with negative reads tended to have more limited localization at the ligament (8.7%) or anterior crus (39.1%), compared with positive reads, which demonstrated more extensive involvement, with bipolar foci (30.0%) or diffuse footplate manifestations (20.0%) more common. Acoustic reflexes were characteristically absent. Conclusions: While HRCT may aid in the diagnosis of otosclerosis and rule out concomitant pathology in certain cases of clinical uncertainty or unexplained symptoms, its sensitivity for otosclerosis remains low. HRCT should not be relied upon to diagnose routine fenestral otosclerosis.
The effect of different analytical platforms and methods on the performance of population-specific adjusted calcium equation
Authors: Jassam N , Narayanan D , Turnock D , Lee G , Earp K , West J , Day A , Jeffery J , Zouwail S , El-Farhan N , Dearman R , Hayden K , Osborne J , Willett S , Barth JH 
Published: May 2020

Background A recent attempt to improve the diagnostic value of adjusted calcium addressed a primary care-specific adjusted calcium equation, but validated the new equation for Roche Cobas, BCG and NM-BAPTA methods only. In this study, we aim to validate a population-specific equation for other methods and platforms. Method We collected retrospective patient data-sets from 15 hospital laboratories using a range of commercially available analytical platforms and methods for calcium and albumin measurements. Raw data-sets were collected and filtered according to Payne’s criteria, and separate adjusted calcium equations were derived for hospitalized and primary care patients. Results Mean albumin and calcium results were significantly higher in primary care populations ( P <  0.0001). The prevalence of hypocalcaemia using adjusted calcium ranged between 6% and 44% for inpatient data-sets and was higher in users of BCG methods. The application of community-specific adjustment equation to primary care data-sets reduced the prevalence of hypocalcaemia (mean 1.7%, range 0.8–3.7%). Conclusion We demonstrated that the use of a community-specific calcium adjustment equation to a primary care population reduces both the percentage and the variation of hypocalcaemia between different laboratories.
Measuring Food Security through Dietary Diversity: Insights from a Field Survey in Rural Uttar Pradesh, India
Authors: Gupta Abha , Mishra Deepak K. 
Published: May 2020

The discourse on food security in India has concentrated upon availability and accessibility of cereals, neglecting the nutritional significance of fruits, vegetables and meat food products. This article attempts to assess the food security level both quantitatively and qualitatively, and level of dietary diversity among socio-economic groups. A cross sectional survey covering 304 households selected through stratified and proportional random sampling methods was conducted in six villages of Uttar Pradesh, India in 2013–2014. Household Food Insecurity Access Scale and Dietary Diversity approach were used to indicate food security. Subjective assessment highlights that despite sufficient availability of food, most of the households were unable to eat the quality of food they preferred. Findings also show predominant concentration of diet towards cereals, milk, root and tuber food products. Muslims, scheduled caste, labourers and households with lower wealth index consumed a less diversified diet, which is statistically significant. This article provides important insights into the strength and limitations of food policy measures and underlines the need to move beyond the dominant cereal-based interventions for food security in emerging economies like India. JEL Code: Q18
Aerobic exercise improves memory and prevents cognitive deficits of relevance to schizophrenia in an animal model
Authors: Mitsadali Idil , Grayson Ben , Idris Nagi F , Watson Linzi , Burgess Matthew , Neill Joanna 
Published: May 2020

Introduction and objectives: Cognitive impairment associated with schizophrenia (CIAS) greatly reduces patients’ functionality, and remains an unmet clinical need. The sub-chronic phencyclidine (scPCP) rat model is commonly employed in studying CIAS. We have previously shown that voluntary exercise reverses impairments in novel object recognition (NOR) induced by scPCP. However, there has not been a longitudinal study investigating the potential protective effects of exercise in a model of CIAS. This study aimed to investigate the pro-cognitive and protective effects of exercise on CIAS using the translational NOR and attentional set-shifting tasks (ASST). Methods: Female Lister Hooded rats were either exercised (wheel running for one hour per day, five days per week, for six weeks; n=20) or not ( n=20) and then tested in a natural-forgetting NOR test. Rats in each group were then administered either PCP (2 mg/kg intraperitoneally (i.p.)) or saline solution (1 mL/kg i.p.) for seven days, followed by seven days washout. Three NOR tests were conducted immediately and two and nine weeks after washout, and a natural-forgetting NOR test was carried out again eight weeks post washout. Rats were trained and tested in ASST from week 6 to week 10 post washout. Results: Non-exercised rats displayed a deficit in both of the natural-forgetting NOR tests, whereas exercised rats did not. The scPCP exercise group did not show the expected deficit in NOR at any time point, and had a significantly ameliorated deficit in the ASST compared to the scPCP control group. Conclusion: Voluntary exercise has long-lasting pro-cognitive and protective effects in two cognitive domains. Exercise improves cognition and could provide protection against CIAS.
Radiomic prediction models for the level of Ki-67 and p53 in glioma
Authors: Sun Xiaojun , Pang Peipei , Lou Lin , Feng Qi , Ding Zhongxiang , Zhou Jian 
Published: May 2020

Objective To identify glioma radiomic features associated with proliferation-related Ki-67 antigen and cellular tumour antigen p53 levels, common immunohistochemical markers for differentiating benign from malignant tumours, and to generate radiomic prediction models. Methods Patients with glioma, who were scanned before therapy using standard brain magnetic resonance imaging (MRI) protocols on T1 and T2 weighted imaging, were included. For each patient, regions-of-interest (ROI) were drawn based on tumour and peritumoral areas (5/10/15/20 mm), and features were identified using feature calculations, and used to create and assess logistic regression models for Ki-67 and p53 levels. Results A total of 92 patients were included. The best area under the curve (AUC) for the Ki-67 model was 0.773 for T2 weighted imaging in solid glioma (sensitivity, 0.818; specificity, 0.833), followed by a less reliable AUC of 0.773 (sensitivity, 0.727; specificity 0.667) in 20-mm peritumoral areas. The highest AUC for the p53 model was 0.709 (sensitivity, 1; specificity, 0.4) for T2 weighted imaging in 10-mm peritumoral areas. Conclusion Using T2-weighted imaging, the prediction model for Ki-67 level in solid glioma tissue was better than the p53 model. The 20-mm and 10-mm peritumoral areas in the Ki-67 and p53 model, respectively, showed predictive effects, suggesting value in further research into areas without conventional MRI features.
A feasibility exploratory study of a novel modality of using patient-reported outcomes (PROsEXPLOR) in the real world
Authors: Grosso Federica , Crivellari Stefania , Bertolotti Marinella , Lia Michela , De Angelis Antonina , Cassinari Antonella , Riccio Carmela , Piovano Pier Luigi , Cappelletti Mauro , Maconi Antonio 
Published: May 2020

Introduction: Patient-reported outcomes (PROs) can help clinicians better evaluate chemotherapy and immunotherapy toxicity based on patient perspectives. In this exploratory study, we tested a simplified PRO questionnaire (sPQ) in routine clinical practice and patient satisfaction with this tool. Methods: We included 16 items related to the main toxicities of chemotherapy and immunotherapy to be filled in by patients. A baseline sPQ was completed by patients before starting treatment and then in the interval between courses for a total of 4 sPQs. Patients communicated the results to a data manager, who alerted the referral oncologist in case of replies differing from the basal or previous sPQ. According to the severity of symptoms, the patient was then referred to the team nurse, the general practitioner, or another specialist. A satisfaction survey was also completed. Results: In a 3-month interval, 27 patients were enrolled. Fatigue and nausea were the most frequent symptoms reported as worsening during treatment. The oncologist was involved in the management of adverse events in 4 cases, home therapy variations were recommended by the dedicated nurse in 14 cases, additional visits were performed in 6 patients, and 1 patient was admitted to the oncology ward. None of the patients had unplanned visits to the emergency department or to the hospital. The sPQ was judged to be simple, useful, and satisfactory. Conclusions: Using sPQs in routine clinical practice was feasible and well-accepted by patients. PROs allowed us to recognize and promptly manage adverse events, reducing unplanned emergency department or hospital visits to zero.
Too Much of a Good Thing? Cerebral Sinovenous Thrombosis Due to Excessive Milk Intake Associated Anemia
Authors: Farias-Moeller Raquel , Siddiqui Sara , Orr Megan , Mondok Lileth 
Published: May 2020

Introduction: In young children, excessive cow’s milk intake causes iron-deficiency anemia, which is associated with hypercoagulable states. We present a case series of 4 toddlers with excessive milk intake iron-deficiency anemia and cerebral sinovenous thrombosis. Methods: Retrospective chart review of 4 patients was performed for patients with cerebral sinovenous thrombosis and iron-deficiency anemia secondary to excessive milk intake. Iron-deficiency anemia was defined as hemoglobin <11 mg/dL, mean corpuscular volume <70 fL, and serum ferritin <12 μg/L. Excessive milk intake was defined as consumption of >24 oz daily. Clinical, laboratory, and radiographic features were reviewed. Results: Age ranged from 12 to 24 months. Average hemoglobin, hematocrit, mean corpuscular volume, and ferritin levels were 6.1 g/dL, 22.7 g/dL, 52.7 fL, and 3.2 ng/mL, respectively. Daily milk consumption ranged from 40 to 60 oz. All patients presented with focal neurologic deficits, including seizures in 3. The location of cerebral sinovenous thrombosis varied, and 3 patients had venous infarcts, one of them hemorrhagic. All patients had a limited diet and were described as “picky eaters” by their parents, and only 1 had transitioned of a bottle. All patients were treated with anticoagulation, iron supplementation, and extensive dietary counseling to reduce cow’s milk intake. Conclusion: Iron-deficiency anemia due to excessive milk intake is an important and preventable etiology of pediatric cerebral sinovenous thrombosis. Focused anticipatory guidance is necessary for at-risk groups to prevent this neurologic emergency.
Change in Lifestyle Behaviors After Preconception Care: A Prospective Cohort Study
Authors: Sijpkens Meertien K. , van Voorst Sabine F. , Rosman Ageeth N. , de Jong-Potjer Lieke C. , Denktaş Semiha , Koch Birgit C.P. , Bertens Loes C.M. , Steegers Eric A.P. 
Published: May 2020

Purpose: To evaluate the effects of preconception care (PCC) consultations by change in lifestyle behaviors. Setting and Intervention: Women in deprived neighborhoods of 14 Dutch municipalities were encouraged to visit a general practitioner or midwife for PCC. Sample: The study included women aged 18 to 41 years who had a PCC consultation. Design: In this community-based prospective cohort study, we assessed initiation of folic acid supplementation, cessation of smoking, alcohol consumption, and illicit drug use. Measures: Self-reported and biomarker data on behavioral changes were obtained at baseline and 3 months later. Analysis: The changes in prevalence were assessed with the McNemar test. Results: Of the 259 included participants, paired analyses were available in 177 participants for self-reported outcomes and in 82 for biomarker outcomes. Baseline self-reported prevalence of no folic acid use was 36%, smoking 12%, weekly alcohol use 22%, and binge drinking 17%. Significant changes in prevalence toward better lifestyle during follow-up were seen for folic acid use (both self-reported, P < .001; and biomarker-confirmed, P = .008) and for self-reported binge drinking ( P = .007). Conclusion: Our study suggests that PCC contributes to initiation of folic acid supplementation and cessation of binge drinking in women who intend to become pregnant. Although based on a small sample, the study adds to the limited body of evidence regarding the benefits of PCC in improving periconception health.
Lower rates of mortality, readmission and reoperation in patients receiving acupuncture after hip fracture: a population-based analysis
Authors: Lin Jeff Chien-Fu , Lin Tzu-Chieh , Cheng Chi-Fung , Lin Ying-Ju , Liang Sophia , Chang Yu-Jun , Liang Wen-Miin 
Published: May 2020

Background: Studies on the effects of acupuncture on mortality and complication rates in hip fracture patients are limited by small sample size and short follow-up time. We aimed to assess the associations of acupuncture use with mortality, readmission and reoperation rates in hip fracture patients using a longitudinal population-based database. Methods: A retrospective matched cohort study was conducted using data for the years 1996–2012 from Taiwan’s National Health Insurance Research Database. Hip fracture patients were divided into an acupuncture group consisting of 292 subjects who received at least 6 acupuncture treatments within 183 days of hip fracture, and a propensity score matched “no acupuncture” group of 876 subjects who did not receive any acupuncture treatment and who functioned as controls. The two groups were compared using survival analysis and competing risk analysis. Results: Compared to non-treated subjects, subjects treated with acupuncture had a lower risk of overall death (hazard ratio (HR): 0.41, 95% confidence interval (CI): 0.24–0.73, p = 0.002), a lower risk of readmission due to medical complications (subdistribution HR (sHR): 0.64, 95% CI: 0.44–0.93, p = 0.019) and a lower risk of reoperation due to surgical complications (sHR: 0.62, 95% CI: 0.40–0.96, p = 0.034). Conclusion: This is the first study to suggest that postoperative acupuncture in hip fracture patients is associated with significantly lower mortality, readmission and reoperation rates compared with those of matched controls.
Listening to the autistic voice: Mental health priorities to guide research and practice in autism from a stakeholder-driven project
Authors: Benevides Teal W , Shore Stephen M , Palmer Kate , Duncan Patricia , Plank Alex , Andresen May-Lynn , Caplan Reid , Cook Barb , Gassner Dena , Hector Becca Lory , Morgan Lisa , Nebeker Lindsey , Purkis Yenn , Rankowski Brigid , Wittig Karl , Coughlin Steven S 
Published: May 2020

Autistic adults are significantly more likely to experience co-occurring mental health conditions such as depression and anxiety. Although intervention studies are beginning to be implemented with autistic adults to address mental health outcomes, little is known about what research autistic adults feel is needed, or what mental health outcomes are of value to them. The purpose of this article is to describe a project that involved more than 350 autistic adults and other stakeholders as coproducers of research priorities on mental health. Through a variety of methods including a large online survey, two large stakeholder meetings, and three face-to-face focus groups, the project team identified five top priorities for mental health research which should be incorporated by researchers and practitioners in their work with autistic adults. These included research to inform trauma-informed care approaches; societal approaches for inclusion and acceptance of autistic individuals; community-available approaches for self-management of mental health; evaluation of adverse mental health outcomes of existing interventions; and improvements in measurement of quality of life, social well-being, and other preferred outcomes in autistic adults. Lay Abstract Autistic adults commonly experience mental health conditions. However, research rarely involves autistic adults in deciding priorities for research on mental healthcare approaches that might work for them. The purpose of this article is to describe a stakeholder-driven project that involved autistic adults in co-leading and designing research about priorities to address mental health needs. Through a large online survey, two large meetings, and three face-to-face focus group discussions involving over 350 stakeholders, we identified five priorities for mental health research desired by autistic adults. These priorities and preferred outcomes should be used to guide research and practice for autistic adults.
Looking good but feeling bad: “Camouflaging” behaviors and mental health in women with autistic traits
Authors: Beck Jonathan S , Lundwall Rebecca A , Gabrielsen Terisa , Cox Jonathan C , South Mikle 
Published: May 2020

Autistic traits are associated with frequent psychological distress, suicidal ideation, and everyday functional challenges. These associations may be especially prominent in women. Some women with autistic traits “camouflage” feelings of awkwardness in typical social situations by effortfully engaging in expected social behaviors. We explored camouflaging because emerging evidence posits an association between camouflaging behaviors and poorer outcomes related to mental health, daily functioning, and access to mental health care. We recruited a sample of 58 women (age M = 25 years; IQ M = 115) who reported that they find social situations confusing and who scored high on a measure of broad autistic traits ( Broad Autism Phenotype Questionnaire score > 3). The majority of participants reported significant levels of psychological distress, suicidal ideation, and daily functioning difficulties. Regression models showed that camouflaging efforts ( Camouflaging Autistic Traits Questionnaire) and autistic traits ( Social Responsiveness Scale, Second Edition) modestly but significantly predicted psychological distress and functional challenges, respectively. In a subgroup of participants with high Camouflaging Autistic Traits Questionnaire scores, camouflaging scores were significantly associated with psychological distress and functional challenges. Camouflaging may help predict when clinicians should be concerned about higher mental health distress in autistic women and may be beneficial to measure as part of a comprehensive, multimethod assessment of mental health in women who report difficulties fitting into social situations. Lay Abstract Women who try to hide or “camouflage” their autistic traits are likely to report that they feel distressed, think of suicide, and/or struggle to function in everyday life. We asked 58 women with autistic traits to complete questionnaires about camouflaging and mental health. Most of these women did not have a formal diagnosis of autism, yet a majority reported that they camouflaged autistic traits, and a large majority reported significant mental health challenges. Some researchers have suggested that women with autistic traits are more likely than autistic men to experience mental health challenges because women may try more to “fit in” socially by camouflaging their autistic traits. Analyses showed that camouflaging was associated with feeling distressed (depressed, anxious, and/or stressed). For women who reported above-average levels of camouflaging, camouflaging was also associated with having thoughts about suicide and struggling to function in everyday life. Trying to camouflage autistic traits was associated with mental health challenges, regardless of whether those traits were very mild or more severe. The findings of this study may influence how mental health professionals evaluate and treat women with autistic traits.