bluuebunny/crossref_metadata_2025_split huggingface dataset:
P2723Diagnosis of acute myocardial infarction in the presence of left bundle-branch block
Authors: Nestelberger T , Cullen L , Lindahl B , Reichlin T , Greenslade J , Giannitsis E , Morawiec B , Koechlin L , Twerenbold R , Boeddinghaus J , Rubini M , Osswald S , Pickering J , Than M , Mueller C 
Published: October 2019

Abstract

Objective
Patients with suspected acute myocardial infarction (AMI) in the setting of left bundle branch block (LBBB) present an important diagnostic and therapeutic challenge to the clinician.

Methods
We prospectively evaluated incidence of AMI, and diagnostic performance of specific electrocardiographic (ECG) and high-sensitivity cardiac troponin (hs-cTn) criteria in patients presenting with chest discomfort to 26 emergency departments in three international, prospective, diagnostic studies. Presence of LBBB, ECG criteria, and final diagnoses were centrally adjudicated by two independent cardiologists using the fourth universal definition of myocardial infarction.

Results
Among 8830 patients, LBBB was present in 247 patients (2.8%). AMI was the final diagnosis in 30% of patients with LBBB, with similar incidence in those with known LBBB versus those with presumably new LBBB (29% vs 35%, p=0.42). ECG criteria had low sensitivity (1–12%), but high specificity (95–100%). The diagnostic accuracy as quantified by the receiver-operating-characteristics curve of hs-cTnT and hs-cTnI concentrations at presentation (AUC 0.91; 95% CI 0.85–0.96 and 0.89; 95% CI 0.83–0.95) as well as that of their 0/1h and 0/2h changes was very high. A diagnostic algorithm (Figure 1) combining ECG criteria with hs-cTnT/I concentrations and their absolute changes at 1h or 2h derived in cohort 1 (45 of 45 (100%) of patients with AMI correctly identified), showed high efficacy and accuracy when externally validated in cohort 2 & 3 (28 of 29 patients, 97%).
Figure 1

Conclusion
Most patients presenting with suspected AMI and LBBB will be found to have diagnoses other than AMI. Combining ECG criteria with Hs-cTn testing at 0/1h or 0/2h allows early and accurate diagnosis of AMI in LBBB.

Acknowledgement/Funding
European Union, Swiss National Foundation, University Hospital Basel, University Basel
P2738Prognosis of the systemic right ventricle further refined: a role for myocardial strain analysis
Authors: Woudstra O I , Van Dissel A C , Van Der Bom T , De Bruin - Bon H A C M , Van Melle J P , Vliegen H W , Van Dijk A P J , Mulder B J M , Meijboom F J , Bouma B J 
Published: October 2019

Abstract

Background
Predicting heart failure in patients a with systemic right ventricle (sRV) due to transposition of the great arteries (TGA) is difficult. Strain parameters are easily available and detect early myocardial damage.

Purpose
To determine the value of strain parameters compared to cardiovascular magnetic resonance (CMR) derived parameters as predictors for heart failure-free survival in patients with an sRV.

Methods
In participants of a multicenter prospective trial, global longitudinal strain (GLS) was assessed on echocardiography using speckle tracking. Cox regression was used to determine the association of sRV GLS and postsystolic shortening, defined as >20% of myocardial contraction appearing after aortic valve closure, with the combined endpoint of progression of heart failure and death, compared to CMR derived parameters.

Results
Echocardiograms of 61/88 participants could be analyzed (age 34±11 years, 66% male, 34% congenitally corrected TGA). Mean GLS was −13.5±2.9% and 13 (21%) patients had postsystolic shortening. During 8 [7–9] years, 15 (23%) patients met the composite endpoint. sRV ejection fraction (mean 39±9%, HR=0.93/% [95% CI 0.87–0.99]), sRV end systolic volume (mean 80±31 ml/m2, HR=1.19 per 10ml/m2 [95% CI 1.01–1.40]), GLS (HR=1.25/% [95% CI 1.01–1.54]) and postsystolic shortening (HR=4.10 [95% CI 1.48–11.37]) were all associated with heart failure-free survival in univariable analysis. Optimal cut-offs for sRV ejection fraction and GLS were 30% and −10.5%, respectively, with comparable predictive value for heart failure-free survival (iAUC=0.66 and iAUC=0.68). Patients with both decreased strain (>−10.5%) and decreased RVEF (<30%) were at highest risk for heart failure and death (HR=19.83 [95% CI 4.92–80.01], iAUC=0.73).
Predicted heart failure-free survival

Conclusion
The predictive value of global longitudinal strain is comparable to CMR derived ejection fraction. Patients with both low ejection fraction and low myocardial strain are at highest risk of heart failure and death. These easily available parameters should be integrated in future risk prediction scores and can be used in the clinic to guide follow-up intensity.

Acknowledgement/Funding
This work was supported by the Dutch Heart Foundation [CVON 2014-18 project CONCOR-genes]
P2750Why should cardiopulmonary exercise testing be routinely used for assessing patients with valvular heart disease?
Authors: Cortina C , Sarrion M , Beltran C , Suberviola V , Briongos S , Sanchez A , Ponz I , Estevez A , Jimenez S , Cano J M , Munoz R 
Published: October 2019

Abstract

Introduction
The role of cardiopulmonary exercise testing (CPET) is unquestionable to assess prognosis in heart failure. In patients with valvular heart disease (VHD), the functional capacity (FC) is crucial to aid in the right timing of surgery. The aim of this study was to compare the assessment of the FC by CPET and NYHA and the correlation between ventilatory efficiency parameters and resting systolic pulmonary artery pressure (SPAP).

Methods
We studied 100 VHD patients (57% female) who underwent a CPET. We calculated the real METS (RM) as indexed peak VO2/3.5 (1 MET=3.5 ml O2/kg/min) and compared to estimated METS (EM) derived by the time of exercise. An agreement analysis between RM, EM and NYHA was calculated. The correlation among VE/Vslope CO2, EqCO2at anaerobic threshold (AT), PETCO2, partial pressure end-tidal CO2 at AT and SPAP was analyzed.

Results
The results are shown in Table and Figure. The RM and the EM were 4.7±1.7 and 5.5±3, respectively (p<0.01) with a low agreement (ICC=0.6, p<0.01). The agreement between NYHA and the classification obtained from peak % of predicted peak VO2 was very low (weighted kappa =0.06, p=0.28). In patients with severe mitral VHD, the ventilatory efficiency parameters were correlated with SPAP (PETCO2 (AT), r=−0.7, p=0.002; EqCO2 (AT), r=0.5, p=0.04:VE/Vslope CO2, r=0.3, p 0.2), whereas in those with severe aortic VHD, these correlations were much lower (PETCO2 (AT), r=−0.3, p=0.13; EqCO2 (AT), r=0.2, p=0.15; VE/Vslope CO2, r=0.18, p 0.31).
Total (n=100) Mitral regurgitation (n=35) Aortic regurgitation (n=23) Age 65 (29–86) 66 (30–84) 65 (11–87) LVEF (%) 62±6 63±6 61±7 SPAP (mmHg) 40±11 39±11 36±8 NYHA I (60%), II (33%), III (7%) I (63%), II (29%), III (9%) I (63%), II (33%), III (4%) Indexed peak VO2 (ml/min/kg) 16±6 17±6 19±8 Peak % predicted VO2 73±18 74±17 79±18 Predicted VO2 AT (%) 58±19 54±19 61±22 Eq CO2 AT 33±6 32±7 32±5 VE/VSlope CO2 33±6 32±7 33±8 PetCO2 AT 34±4 36±4 36±5
Type and degree of VHD

Conclusions
NYHA scale and estimation of METS derived from the time of exercise clearly overestimated the FC of our population. In our series, the ventilatory inefficiency in patients with mitral VHD could be a surrogate marker of advanced disease and could lead to an earlier intervention.
P2756Risk of stroke subsequent to infective endocarditis: a nationwide study
Authors: Ostergaard L , Andersson N W , Kristensen S L , Dahl A , Bundgaard H , Iversen K , Bruun N E , Gislason G , Pedersen C T , Valeur N , Kober L , Fosbol E L 
Published: October 2019

Abstract

Background
Patients with infective endocarditis (IE) are at high risk of cerebral embolization, however little is known about the risk of stroke subsequent to IE in patients with stroke during IE admission.

Purpose
To investigate the risk of stroke after discharge of IE in patients with stroke during IE admission compared with patients without stroke during IE admission.

Methods
Using Danish nationwide registries we identified non-surgically treated patients with IE discharged alive, in the period 1996–2016. The study population was grouped in 1) patients with stroke during IE admission and 2) patients without stroke during IE admission. Crude cumulative risk of stoke were calculated using the Aalen-Johansen estimator accounting for death as a competing risk. Multivariable adjusted Cox proportional hazard analysis was used to compare the associated risk of stroke between groups. We identified differentials in the associated risk of stroke during follow-up between groups (p=0.006 for interaction with time), and follow-up was split into 0–1 year and 1–5 years time periods.

Results
We identified 4,284 patients with IE, 239 patients (5.6%) with stroke during IE admission (median age: 71.9 years, 58.2% males), and 4,045 patients (94.4%) without stroke during IE admission (median age 69.7 years, 64.8% males). The crude cumulative risk of stroke within 1 year of follow-up is shown in Figure Panel A, and with 1 to 5 years of follow-up in Figure Panel B. In multivariable adjusted analyses, the associated risk of stroke was higher in patients with stroke during IE admission within a follow-up period of 1 year, HR 3.21 (95% CI: 1.66–6.20) compared with patients without stroke during IE admission. From 1 to 5 years of follow-up, we identified no difference in the associated risk of stroke between groups, HR 0.91 (95% CI: 0.33–2.50).
Cumulative incidence of stroke

Conclusion
Non-surgically treated patients with IE who had a stroke during IE admission were at significantly higher associated risk of subsequent stroke – although not significant beyond 1 year after discharge from IE. These findings underline the need for identification of causes and mechanisms of recurrent strokes after IE to develop preventive means.
P2763Clinical prognosis of pure right-sided infective endocarditis without association to cardiac devices or intravenous drug abuse
Authors: Vilardell P , Moral S , Bosch D , Morales M , Frigola J M , Albert X , Robles R , Aboal J , Ballesteros E , Brugada R 
Published: October 2019

Abstract

Background
Pure right-sided infective endocarditis (RSIE) without association with cardiac devices or intravenous drug users (IVDUs) is an entity with unclear predisposing factors and prognosis.

Purpose
To evaluate predisposing factors and prognosis of pure RSIE compared tothose associated to cardiac devices or IVDUs.

Methods
280 consecutive patients with endocarditis were included retrospectively in a protocol of clinical and imaging follow-up. Endocarditis-related event was defined as endocarditis mortality or open-surgery requirement. Besides, a review and meta-analysis of the literature between january 2000 and december 2018 were performed.

Results
Fifty-two (19%) patients presented RSIE: 20 of them (39%) were pure RSIE. Intravascular catheters carriers (25% vs 3%; p=0.026) and congenital heart diseases (20% vs 0%; p=0.018) were associated to pure RSIE. These patients demonstrated the worst clinical prognosis, with the highest in-hospital mortality (25% vs 3%; p=0.026) and endocarditis-related event rate (45% vs 6%; p=0.001), being pure RSIE independently associated with in-hospital endocarditis-related events (OR=8.40; 95% CI, 1.13–62.68; p=0.038). Four studies, including ours, with 315 participants diagnosed of RSIE were evaluated in meta-analysis: 94 individuals (30%) presented pure RSIE.This group demonstrated a higher in-hospital mortality than those with cardiac devices or IVDUs (RR=2.854; 95% CI, 1.640–4.965; P<0.001; I2=0.0%; Figure 1).
Figure 1. RSIE and in-hospital mortality based on groups: cases with pure RSIE versus those with cardiac devices or IVDUs.

Conclusions
Pure RSIE is the worst prognosis group among RSIE with the highest endocarditis-related event rate and in-hospital mortality. This growing group should stake out the benign impression and recommendations given to RSIE among IE patients.
P2765Efficacy of venous recanalization by noninvasive pulsed cavitational ultrasound therapy on swine model of acute deep venous thrombosis
Authors: Khider L , Goudot G , Del Giudice C , Mirault T , Bruneval P , Galloula A , Amemiya K , Vion M , Remond M , Tanter M , Pernot M , Messas E 
Published: October 2019

Abstract

Background
Post thrombotic syndrome is a frequent complication of deep venous thrombosis and is associated with high morbidity and hospitalization. Treatments currently available are invasive, involve use of endovenous procedures with stents and balloons, and frequently require general anesthesia. Pulsed cavitational ultrasound therapy (PCUT) emerged recently as a new technique to destroy remotely soft tissue. We recently demonstrated that PCUT was able to recanalize non-invasively in in vitro model of acute venous thrombosis (human blood clot).

Purpose
We aim to test the safety and efficacy of venous recanalization by noninvasive PCUT in vivo swine model of acute venous thrombosis.

Methods
All the experiments were performed on White large X Landrace swine. We induced an acute femoral deep venous thrombosis by using occlusive balloons introduced from jugular and popliteal vein combined with local injection of 50 IU of human thrombin. A 3 cm length occlusive thrombosis was obtained after 2 hours. Swines were divided in three groups: one with PCUT without follow-up (n=11), one with PCUT and follow-up at 14 days (n=8), and a control group also followed for 14 days (n=5). Acutely and during the follow up all swines received curative anticoagulation. To achieve PCUT, a 2.25 MHz transducer centered by a linear probe was used and cavitation was obtained in the center of the vein (Figure). After manual determination of thrombus location, a robotic arm was used to automatically move the transducer along the thrombus. Effectiveness of recanalization was evaluated by echo-Doppler and phlebography. Safety was assessed by Doppler ultrasound of the insonified area (artery, veins and surrounding tissue) and by histological analysis (local femoral vein and artery and lungs for pulmonary embolism).

Results
Among the 24 swines, we obtained 22 occlusive venous thromboses and 2 partial. The median length of the thrombus was 26±4.4 mm with vein diameter of 8.5±1.6 mm. Acutely, thrombosis recanalization was systematically obtained among the 19 swine with PCUT with median treatment duration of 33 minutes with residual diameter of 2.9±0.9 mm. No extravasation of contrast material or hematoma was observed after the therapy. After a 14-day follow-up, 75% of recanalisation remain permeable vs. 0% of vein permeable in the no therapy group (p=0.008). Residual diameter was 2.6±1.2 mm, which correspond to 50% of the venous diameter. No vein or artery damage and no embolism or pulmonary infarction was observed in all pigs.
Figure 1

Conclusion
We have demonstrated in vivo the safety and the efficacy of PCUT for non-invasive venous recanalization, persistent after 2 weeks.

Acknowledgement/Funding
French society of cardiology
P2781How to bridge residual distance to target low-density-lipoprotein cholesterol in stroke patients after initial statin therapy?
Authors: Yan B P Y , Chan C K Y , Lai W H S , To O T L 
Published: October 2019

Abstract

Background
Current guidelines recommend intensive low-density-lipoprotein cholesterol (LDL-C) lowering to target LDL-C <1.8mmol/L after ischemic stroke (IS). Residual distance to LDL-C target can help select further treatment options after initial statin therapy.

Purpose
We aimed to evaluate residual distance to target LDL-C and the proportion of IS patients who are projected to reach target LDL-C by different statin and non-statin lipid lowering strategies.

Methods
We retrospectively analyzed 5,025 patients admitted with IS or transient ischemic attack who survived 1 year from an academic institution in Hong Kong between Jan 2005 and Sep 2017. Patients were divided into (i) high potency (HP-S; rosuvastatin ≥20mg, atorvastatin ≥40mg or simvastatin ≥80mg); (ii) non-high potency (NHP-S; other statin doses) statin users and (iii) no statin therapy. We calculated the mean distance and percentage LDL-C reduction required to reach target LDL-C. We assumed up-titration from NHP-S to HP-S would further reduce LDL-C by 5–15%; addition of ezetimibe 15–25%; up-titrate to HP-S plus ezetimibe 20–40% and combine statin with proprotein convertase subtilsin-kexin type 9 inhibitor (PCSK-9) 40–60%.

Results
Of 5,025 patients (56.3% males, mean age 69.1±11.5 years), 62.4% (3134/5025) had LDL-C ≥1.8mmol/L at 12-months after index stroke with 16.7% (839/5025), 80.9% (4064/5025) and 2.4% (122/5025) of patients on no statin, NHP-S and HP-S, respectively. 58.1% (2362/4064) of NHP-S and 60.7% (74/122) of HP-S users did not reach LDL-C target. Among these patients, the mean LDL-C was 2.5±0.6 and 2.8±1.0mmol/L; mean residual distance to target 0.7±0.6 and 1.0±1.0mmol/L; and mean percentage LDL-C reduction required to reach target LDL-C goal was 23.3±15.1% and 29.5±18.1%, respectively. The proportion of NHP-S users projected to reach target LDL-C is 34.9% (824/2362) by up-titrating/switching to HP-S, 57.2% (n=1352/2362) by addition of ezetimibe, 84.5% (n=1997/2362) by up-titration to HP-S plus ezetimibe and 98.6% (2330/2362) with PCSK-9 inhibitor (Figure 1). The proportion of HP-S users projected to reach target LDL-C is 43.2% (32/74) by addition of ezetimibe and 94.6% (70/74) with PCSK-9 inhibitor (Figure 1).

Conclusion
The use of high-potency statin is low and more than 50% of statin users did not reach target LDL-C at 12-months after index stroke. Combined up-titration to high-potency statin plus addition of ezetimibe is expected to bridge residual distance to target LDL-C in majority of stroke patients.

Acknowledgement/Funding
Supported in part by a research grant from Investigator-Initiated Studies Program of Merck Sharp & Dohme (Asia) Ltd.
P2782Specific air pollution indicators are related to recurrence of ischemic stroke-a nationwide cohort study with surveillance system by time-stratified case-crossover study design
Authors: Li A H , Chan C L , Wu C Y 
Published: October 2019

Abstract

Background and objective
Ischemic stroke (IS) is the 2nd killer in Taiwan. There was no studies of air pollution indicators (API's) in nationwide database, on their relationship to IS recurrence. We aimed to analyze the IS incidences, its recurrence risk related to API's.

Methods
We used LHID 2005 (Longitudinal Health Insurance Database 2005) from National Health Institute Research Database (NHIRD), i.e. the entire original claim data of randomly sampled 1,000,000 beneficiaries in 2005. The national API surveillance database (PM2.5, PM10, CO, SO2, NO,NO2, NOx, O3) was incorporated with it. The IS incidences was computed by obtaining 1st admission for IS (ICD9–433, 434, 435), and the recurrence was on second IS within 30 days of 1st one. To minimize the confounding effect of comorbidities, we used a time-stratified case-crossover study design, proposed by Maclure (1991), for transient effects on acute events' risk; it is characterized by that each subject serves as his or her own control according to fixed individual characteristics, such as age, gender, lifestyle, socio-economic status, genetics and physiological status, etc. The API exposure was analyzed on the re-admission date (lag0), and 1 to 6 day before re-admission (lag1, lag2 ... lag6 etc.).

Results
The IS recurrence-readmission is strongly associated with SO2 peak level 5 days before (lag5 – 95% CI: 1.011–1.023, p=0.004) for patients above 20. Significant association of IS recurrence with PM2.5, SO2 O3, SO2 is noted in different patient groups.
Table 1. Basic demographics of ischemic stroke in Taiwan (2005–2013) Ischemic stroke N % Age, mean ± SD 68.94±12.8 Male 11832 58% Other forms of chronic ischemic heart disease (ICD9–414) 1496 7% Diabetes mellitus (ICD9–250) 6679 32% Essential hypertension (ICD9–401) 9038 44% Disorders of lipoid metabolism (ICD9–272) 4142 20% Heart failure (ICD9–428) 670 3% Hypertensive heart disease (ICD9–402) 2333 11%
Figure 1. Hazard Ratio of specific API's in IS (only shown with statistical significance): those left to line 1.0 with protective effect and vice versa (20–45, 46–64 and 65 above representative meaning for age range).

Conclusion
Specific API's are strongly associated with IS recurrence. We need a prospective cohort study designed on this topic.
P2788First argentine national registry of echocardiograpphic aortic dimensions: body surface area, age and ethnicity are determinants of aortic dimensions
Authors: Carrero C , Constantin I , Benger J , Makhoul S , Baratta S , Cintora F , Lopez M C , Toldo C , Forte E , Recalde L , Ayon M , Schiavone L , Manganiello C F , Asch F M , Bagnati R 
Published: October 2019

Abstract

Background
Transthoracic echocardiography (TTE) remains the screening tool of choice for thoracic aorta (TA) dilatation. Differences in TA diameters (TAD) according to gender (G), age (A) and body surface area (BSA) have been previously reported. However, these reports are limited by a small sample size, different measurement sites or heterogeneous cohorts. There is scarce data on the influence of ethnicitiy on TAD. Moreover, surgery indication for TA aneurysms is still based mainly on absolute TAD with no reference to G, A or BSA.

Purpose
We designed a prospective nationwide multicenter registry to determine the normal range of TAD at all TA segments in healthy adults of both G and their correlations with A, ethnicity and BSA.

Methods
Healthy adult individuals without cardiovascular risk factors, TA aneurysm, aortic valve disease, cardiac surgery or genetic aortopathies were recruited from 53 centers in Argentina. TTEs were acquired and measured following standard protocols based on EACVI/ASE Guidelines. TAD were measured at six levels: annulus, sinuses of Valsalva, sinotubular junction, tubular ascending aorta, aortic arch and proximal descending aorta. Annulus was measured at mid-systole (inner to inner edge method) and all other at end-diastole (leading to leading edge).
Multiple linear regression models were conducted to obtain coefficients of determination (R2) and 95% prediction intervals. We defined upper normal limits (95th percentile) for 4 age categories, both G and analyzed differences according to ethnicity.

Results
The MATEAR registry included 905 healthy adult patients (mean age: 38.3±13 years, 508 women, BSA: 1.8±0.2 m2). 529 (58.4%) were caucasian and 332 (36.6%) native-american, representative of the ethnic composition of Argentine population.
Pooled data showed a positive correlation between all TAD and A or BSA (p<0.001), similar in both G. Women had smaller absolute TAD due to their lower BSA. Nomograms were obtained for 4 age categories to predict TAD from BSA with no need of G distinction. Native americans showed significatly lower absolute and indexed TAD than caucasian (p<0.01) from annulus to isthmus.
TAD differences according to ethnicity

Conclusions
While age and BSA were significant determinants of aortic dimensions at six levels, we have also detected differences in TAD according to ethnicity, suggesting normative values should also be defined for each ethnic group. We propose nomograms of indexed TAD for different age and ethnic groups without G distinction.