bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Anterior-posterior Functional Connectivity Disconnection in the Elderly with Subjective Memory Impairment and Amnestic Mild Cognitive Impairment
Authors: Tao Wuhai , Sun Jinping , Li Xin , Shao Wen , Pei Jing , Yang Caishui , Wang Wenxiao , Xu Kai , Wang Jun , Zhang Zhanjun 
Published: May 2020

Background:
Subjective Memory Impairment (SMI) may tremendously increase the risk of
Alzheimer’s Disease (AD). The full understanding of the neuromechanism of SMI will shed light on
the early intervention of AD.

Methods:
In the current study, 23 Healthy Controls (HC), 22 SMI subjects and 24 amnestic Mild Cognitive
Impairment (aMCI) subjects underwent the comprehensive neuropsychological assessment and
the resting-state functional magnetic resonance imaging scan. The difference in the connectivity of the
Default Mode Network (DMN) and Functional Connectivity (FC) from the Region of Interest (ROI) to
the whole brain were compared, respectively.

Results:
The results showed that HC and SMI subjects had significantly higher connectivity in the region
of the precuneus area compared to aMCI subjects. However, from this region to the whole brain,
SMI and aMCI subjects had significant FC decrease in the right anterior cingulum, left superior frontal
and left medial superior frontal gyrus compared to HC. In addition, this FC change was significantly
correlated with the cognitive function decline in participants.

Conclusion:
Our study indicated that SMI subjects had relatively intact DMN connectivity but impaired
FC between the anterior and posterior brain. The findings suggest that long-distance FC is more
vulnerable than the short ones in the people with SMI.
Gender-related Differences in Sedentary Behavior of Japanese Living Overseas in Malaysia
Authors: Izawa Kazuhiro P. , Oka Koichiro 
Published: May 2020

Background:
The purpose of the present study was to clarify the differences in social demographic
factors and sedentary behavior by gender in Japanese living overseas in Malaysia.

Methods:
First, 130 subjects were surveyed by self-entry questionnaire for statistical factors related
to social demographics and sedentary behavior. These factors were age (years), gender (man/woman),
body mass index (BMI, kg/m2), educational history (>13 years, %), employment (full-time
or part-time, yes, %), alcohol intake (a certain amount, yes, %), smoking behavior (yes, %), and
marital status (yes, %). BMI, as obtained from the participants’ weight and height, was collected
from the self-reported questionnaire and assessed. Sitting behavior time as an index of sedentary behavior
on workdays, non-workdays, and total time was identified by questionnaire. Data were analyzed
using the chi square-test and t-test, respectively. The criterion for a statistically significant difference
was p < 0.05.

Results:
Finally, 107 subjects (68 men, 39 women) were analyzed. The ratios of social demographic
factors of the men versus women group were age (58.5 ± 14.7 vs. 61.0 ± 12.1 years, p = 0.36),
BMI (23.1 ± 2.6 vs. 21.8 ± 2.6 kg/m2, p = 0.01), educational history (86.7% vs. 56.4%, p < 0.001),
employment (51.5% vs. 10.3%, p <0.001), alcohol intake (86.7% vs. 35.9%, p < 0.001), smoking
behavior (30.9% vs. 10.3%, p = 0.01), and marital status (88.2% vs. 100%, p = 0.02). Sitting behavior
time was 501.8 ± 254.6 vs. 346.0 ± 153.4 minutes (p < 0.001) on workdays, 415.1 ± 225.3
vs. 320.6 ± 178.7 minutes (p = 0.019) on non-workdays, and 458.5 ± 203.9 vs. 333.3 ± 132.1 minutes
(p < 0.001) in total.

Conclusion:
These findings indicated that social demographic factors and sitting behavior time differed
by gender. However, there are some limitations. This was a cross-sectional study conducted
in only one city with a small number of participants who completed a self-entry questionnaire. In
conclusion, assessment of the differences in social demographic factors and postponement of sedentary
behavior for both genders may reduce sitting behavior time in overseas Japanese residents and
may help in developing public health strategies.
PCF Based Formalin Detection by Exploring the Optical Properties in THz Regime
Authors: Bulbul Abdullah A.M. , Jibon Rayhan H. , Das Sumon K. , Roy Tonmoy , Saha Avijit , Hossain Mohammad B. 
Published: May 2020

Introduction:
Ongoing amelioration of semiconductor nano-crystal in chemical sensing
applications has led the Photonic Crystal Fiber (PCF) as the most appropriate candidate for chemical
sensing. A PCF based sensor model has been proposed in this paper.

Objective:
The aim of this model is to detect formalin at a high level of sensitivity.

Method:
This sensor model has been designed and simulated in COMSOL MULTIPHYSICS to analyze the sensing performance
based on the optical parameters such as relative sensitivity, confinement loss, and effective material loss. Formalin solution is placed
into the core and then the simulation is performed in THz regime ranging from 1 to 2 THz to carry out the optical properties. Simulation data collected from COMSOL are used in Matlab to carry out the graphical representation of the optical parameters.

Results:
Simulation results demonstrate that the sensor model inherits high relative sensitivity of approximately 77.71 % at 1.8 THz.
In addition to that, the proposed sensor exhibits zero confinement loss above 1.3 THz and very low effective material loss in the THz
regime for the optimum model.

Conclusion:
All the optical parameters maintain standard and desirable values in the THz regime. Besides, the flexible fabrication of
the proposed model is feasible using existing fabrication methods. Simulation results validate the high performance of this proposed
model in formalin detection.
Nanocluster Structure of Pistacia atlantica subsp. Kurdica Turpentine and its Antibacterial Effects
Authors: Darehbagh Ramyar R. , Ramezani Rojin , Hosseinpanahi Afra , Fotoohi Ahmad , Rouhi Samaneh 
Published: May 2020

Background:
Medicinal herbs such as Pistacia Atlantica (P. Atlantica) subsp. Kurdica
have antimicrobial effects. The present study is aimed to investigate the nanocluster structure of P.
atlantica subsp. Kurdica turpentine and its composing elements and antibacterial effect.

Methods:
100 μl ethanol was used to dissolve oily turpentine. 2, 2.2, 2.4, and 2.6 μg/μl of turpentine
were used for investigating the antibacterial effects using disk and well diffusion methods. Elemental
and nanocluster structure analyses were performed by Energy-Dispersive X-Ray Microanalysis
(EDXMA) and Field Emission (FE)-scanning electron. Two-way analysis of variance
(ANOVA) and Bonferroni test were used for data analysis (p ≤ 0.001).

Results and Discussion:
EDXMA elemental analysis of turpentine included: Zinc (Zn), Magnesium
(Mg), Fluorine (F), Oxygen (O), Silicon (Si), Carbon (C), and Argentum (Ag). A topography
image of the turpentine showed a nanocluster surface with bright clusters in the background. The
largest diameters of the growth inhibition zones (24.67 ± 0.58 mm in the disk diffusion and 23.67
± 1.53 mm in the well diffusion) that were created by turpentine were observed against S. aureus
ATCC 25923 at the concentration of 2.6 μg/μl. The diameter of the inhibition zone around bacterial
growth had a direct relationship with turpentine concentration (p ≤ 0.001).

Conclusion:
The nanocluster structure of turpentine and its composed elements were detected in
this research. Moreover, the antibacterial effects of turpentine were proved. Herbal substances are
widely used in medical applications. Different elements of P. atlantica subsp. Kurdica turpentine
can be used as antibacterial agents, but more in-vitro and in-vivo studies should be performed in
this field.
Recent Patents on Conical Pick and Flat Pick for Coal Mining
Authors: Wang Yanxiang , Yang Daolong , Xing Bangsheng , Yu Wenqiang , Guo Jie , Xu Hao 
Published: May 2020

Background:
Coal mining machines are the primary equipment used for the comprehensive
mining of medium and thick coal seams. A shield machine is used to modify the geological structure of
the soil, especially in urban subway tunnel engineering. The cutting and tunneling equipment have
greatly improved the efficiency of coal seam mining and rock tunneling construction, but the consumption
of picks in mining and tunneling is very high.

Objective:
In order to reduce the consumption of picks, it is necessary to obtain the change of temperature
inside the pick in the process of cutting.

Methods:
This paper introduces a temperature measurement method to measure the temperature inside
the conical and flat pick to provide a reference for the design and manufacture of picks.

Results:
The temperature measurement method used in flat and conical pick can obtain the temperature
change inside the pick under the actual working condition, which has a considerable guiding significance
to promote the development of coal mining.

Conclusion:
This study provides an important basis for the safety of mining operations and for prolonging
the service life of picks. It has a strong innovation value and broad practicality.
Design and Simulation of a Novel Planetary Gear Mixer for Dry Particle Materials
Authors: Zhang Lei , Bao Jiusheng , Zhang Qingjin , Yin Yan , Liu Tonggang , Huang Shan 
Published: May 2020

Background:
Mixer with excellent performance is the essential premise for high-quality
mixture production to ensure uniformity. In the fields of food, pharmacy, powder metallurgy and machinery
industry, materials mixing is an indispensable process. At present, the mixing efficiency and
performance of the traditional mixer are very low, which has its own limitations, and it is difficult to
ensure the quality of the mixture, which seriously affects the safety and reliability of the mixture products
such as synthetic drugs, chemical reagents, cement, synthetic fiber, etc.

Objective:
In order to improve the mixing performance by improving the mixing uniformity, volume
utilization, reducing the mixing time and mixing blind area, a novel planetary gear mixer for dry particle
materials is designed. Its blades can rotate and the angle of attack can be changed at any time, which
realizes the multi-degree of freedom movement of the blades.

Methods:
Firstly, the shortcomings of three kinds of traditional mixers are compared and analyzed, a novel planetary gear
mixer for dry particle is proposed and its structural characteristics are described. Then, the transmission system and blade
parameters of the mixer are designed and calculated, and the blade parameters of the mixers are optimized based on ADAMS
and EDEM. Finally, the comparative simulation experiment between planetary gear mixers and SHR-10A mixers is carried
out. The experiment is used to inquiry on the mixing performance of the new planetary gear mixer.

Results:
The complementary cycloid was the ideal mixing trajectory of the blade. The most distinctive
feature of this motion is that the attack angle of the blade can change in all directions. When the blade
parameter p = 11, the Lacey index rises the fastest and the mixing degree is the largest, which indicates
that the optimal mathematical model of the blade is ‘y2= 22x’. The comparison with SHR-10A mixer
showed that spatial distribution of multi-degree of freedom blades in the new planetary gear mixer has
strong dispersion effects on particles and better mixing performance.

Conclusion:
The planetary gear mixer for dry particle materials is a new type of mixer, which is composed
of two sets of blades whose attack angle can be changed at any time. Convection and shear mixing
dominate its mixing space, which is conducive to its rapid and full mixing, improving the mixing
performance. The dry particle planetary gear mixer for dry particle materials has great developmental
value and wide engineering application prospect. In this article, various patents have been discussed.
Análisis de la correspondencia Decir-Hacer- Reportar en terapia: un estudio piloto
Authors: Froxán-Parga María Xesús , Ávila-Herrero Isabel , Trujilo-Sánchez Carolina , Serrador-Diez Concepción , Núñez de Prado-Gordillo Miguel 
Published: May 2020

Los terapeutas comúnmente desean mejorar el grado de coherencia entre lo que los clientes dicen que harán, lo que hacen y lo que reportan haber hecho después. Esta descripción de la práctica clínica se asemeja a los experimentos realizados en el ámbito de la correspondencia Decir-Hacer-Reportar (D-H-R). Sin embargo, la investigación sobre la correspondencia en entornos aplicados, naturales y/o ecológicos es escasa. El objetivo principal de este trabajo fue establecer una tarea que nos permitiera evaluar la correspondencia D-H-R en un entorno más ecológico (el contexto terapéutico), además de investigar cómo afecta la terapia a la correspondencia. Se analizó individualmente la evolución PRE-POST de la correspondencia en dos grupos, experimental (terapia) y control (no terapia), para tres grupos de conductas-objetivo (Beber, Comer yActividades). La tarea experimental demostró ser apropiada para evaluar la correspondencia en un entorno más ecológico. Los resultados sobre el efecto de la terapia en la correspondencia no fueron concluyentes. Sin embargo, los diferentes estudios de interacción verbal que ocurren a lo largo de la terapia y de conducta gobernada por reglas apuntan a que uno de los procesos clave que subyacen al resultado clínico exitoso es el refuerzo sistemático de la correspondencia.
The Beneficial Effect of Paricalcitol (Zemplar) on Secondary hyperparathyroidism Refractory to Calcitriol (Calcijex) and Cinacalcet HCl (Mimpara) in Patients on Maintenance Hemodialysis: A Prospective and Crossover Study
Authors: El-Reshaid Kamel , Al-Bader Shaikha , El-Marzabani Salah 
Published: May 2020

Paricalcitol, 19-nor-1, 25-dihydroxvitamin D2, is a novel 1,25–dihydroxyvitamin D2 analogue, which has greater potential to suppress parathyroid hormone without inducing significant hypercalcemia and hyperphosphatemia. We therefore investigated its role in treatment of patients with moderate to severe secondary hyperparathyroidism (SHPT) who were refractory to conventional therapy with Calcitriol and Cinacalcet HCl. Eight patients were recruited in whom conventional therapy was stable over the past 3 months. After a washout period of 2 weeks, calcijex injections were replaced by Paricalcitol. Paricalcitol induced more suppression of iPTH compared to the conventional therapy without significant hypercalcemia, hyperphosphatemia or side effects. The conversion ratio was approximately 1:2.5 (calcitriol:paricalcitol). In conclusion, injectable Paricalcitol is superior to Calcitriol in treatment of SHPT.
Keywords: Cinacalcet, Calciferol, hemodialysis, hyperparathyroidism, Paricalcitol.
Acute toxicity of Aristolochia longa L. of aqueous extract in mice
Authors: Merouani Nawel , Belhattab Rachid 
Published: May 2020

Aristolochia longa L. (Aristolochiaceae) is widely used to treat breast cancer in Algerian traditional medicine. The present study was conducted to investigate the effects of ingestion of aqueous extracts of different parts of the plant on liver and kidney functions in wistar albinos mice. Acute oral toxicity was performed to determine DL50, this toxicity was carried out by the oral administration in single doses of 0–12 g/kg for tubers aqueous extracts and 2 g/kg and 5 g/kg for aerial and fruit aqueous extract respectively. General behavior, adverse effects and mortality were determined for up to 14 days. The animals were sacrificed and biochemical study was done. The acute oral toxicity result revealed that LD50 of the tubers and fruit aqueous extracts was respectively more than 12 g/kg and 5 g/kg, but DL50 of the aerial aqueous extract was at 5 g/kg. The result revealed also that liver and kidney function of different groups receiving high doses was affected as ASAT, ALAT, Urea, creatinine was significantly increased as compared to control group. Histological examination showed alterations of the renal parenchyma and the liver which is greater in animals treated with high dose. Thus, caution should be exercised with its usage.
Keywords: Acute toxicity, Biochemical parameters, Histological examination Aristolochia longa L.
Quality of Life Assessment of Hypertensive Patients in a Tertiary Care Teaching Hospital in Jaipur
Authors: Sharma Kushagra , Mishra Nikhil , Kumar Ranjeet 
Published: May 2020

Background: Hypertension is the well-known risk factor for mortality and morbidity. About 7.1 million population worldwide dies each year due to cause of hypertension. It directly effects persons quality of life. Methods: Total number of 128 Hypertension diagnosed Patient’s data were collected under this study who were admitted to the General Medicine wards of tertiary care teaching hospital. WHO BREF questionnaires were given and filled forms by patients were collected. Result: In physical health 42 Patients are with excellent health, 81 Patients are fall under the moderate health and 5 Patients are with poor physical health status. In psychological assessment 36 Patients are with excellent health 83 Patients are fall under the moderate health and 9 Patients are with poor physical health status. In Social relation, 15 Patients are with excellent health, 98 Patients are fall under the moderate health, and 15 Patients are with poor physical health status. In environmental assessment, 57 Patients are with excellent health, 41 Patients are fall under the moderate health and 31 Patients are with poor physical health status. Conclusion: This study has shown overall moderate QOL with mean 3.25 and SD 0.63 among hypertensive patients according all four domains. Physical activities and marital status were important independent factors affecting both domains in QOL. Older age was associated with lower QOL in physical health. Presence of co-morbidity in hypertension patients are an important health issue influencing their satisfaction in physical health. Interventions targeted towards improving QOL of disadvantage patients are needed in the setting.
Keywords- Mental Health Assessment, WHO BREF, Quality of Life, Hypertension.
A Review on Epilepsy and its Management
Authors: Potnis V.V. , Albhar Ketan G. , Nanaware Pritamsinh Arjun , Pote Vishal S. 
Published: May 2020

Today, people face various types of stress in everyday fast life and most people in the world suffer from various neurological disorder. Epilepsy is one of the most common neurological disorders of the brain, affecting about 50 million people around the world, and 90% of them are coming from developing countries. Genetic factors and brain infection, stroke, tumors and epilepsy cause high fever. It imposes a great economic burden on the health systems of countries associated with stigma and discrimination against the patient and also his family in the community, in the workplace, school and home. Many patients with epilepsy suffer from severe emotional stress, behavioral disorders and extreme social isolation. There are many different types of seizure and mechanisms by which the brain generates seizures. The two features of generating seizures are hyperexcitability of neurons and a hyper synchronousneural circuits. A variety of mechanisms alters the balance between excitation and inhibition in predisposing brain local or generalized hyperexcitability region and a hypersynchronia. Purpose of the review is to discuss the history, epidemiology, etiology, pathophysiology, classification of epilepsy, symtomps, diagnosis, management of epilepsy and future trends.
Keywords: Anti-epileptic drugs, pathophysiology, seizures, epidemiology, hypersynchrony
Statistical Retrospective Analysis of Spontaneous Abortions in Sidi Bel Abbes Region
Authors: Mellali Sarah , Haoud Khadidja , Bouguetaia Mohammed el amin , Diaf Mustapha 
Published: May 2020

Objective: The aim of our study was to identify modifiable risk factors for miscarriage and to estimate the preventable proportion of miscarriages that could be attributed to these risks. Materials and Method: We carried out an epidemiological study of pregnancy loss in the Sidi Bel Abbes region from 2010 to 2015, with a total of 54720 livebirths and 4349 of spontaneous abortions (SA). The risk of spontaneous abortion related to the fetal loss age, maternal age; parity and previous spontaneous abortions was studied. Results: The rate of spontaneous abortions varies between 7% and 9% and appears to remain constant over the six years, with an average incidence of 8%. We also observed a significant increase in the incidence of SA with the increase in maternal age. 77% of SA occurred before 12 weeks of gestation. The peak incidence occurred during the second month of pregnancy, between 6th and 10th, the rate of AS is the highest among primigests. The incidence of SRA in our study is within the range suggested by these different studies, with a SRA rate of 5%. Fetal loss is high in women in their late 30s or older, irrespective of reproductive history. Conclusion: The fact remains that the risk factors remain the same, namely, the increase in maternal age (inducing an increase in chromosomally unbalanced designs) and primigestity.
Keywords: Spontaneous, abortion, epidemiological, study, risk, factors.
Hydroxychloroquine for COVID-19: A review and a debate based on available clinical trials/case studies
Authors: Badgujar Kirtikumar Chandulal , Badgujar Ashish B. , Patil Vikrant P. , Dhangar Dipak V. 
Published: May 2020

Hydroxychloroquine (HCQ) as a drug grabbed serious attention of whole world in dealing with COVID-19 pandemic. Recently some in-vitro and in-vivo study showing possible inhibition of SARS-CoV-2 by use of HCQ. However at the same time, some case studies showing NO clinical benefit/ poor clinical outcome with substantial detrimental adverse effects by use of HCQ in treatment of coronavirus disease-2019. Thus, the HCQ use (in COVID-19 treatment) is of current international interest, although a consensus has not yet been reached. More evidences are still required to prove efficacy of HCQ against COVID-19. In view of this, the present review highlights the current ongoing research related to use of HCQ in treatment coronavirus disease-2019. The present review will discuss the possible anti-viral mechanism of HCQ, prophylaxis strategy and effect of HCQ against SARS-CoV-2 virus in-vitro study. Further this review also summarizes and debates all available clinical trials/ case studies of HCQ use against COVID-19 (with clinical outcome). Finally possible detrimental adverse effects are also discussed considering the public health and pharmacovigilance concern.
Keywords: Potency of hydroxychloroquine; COVID-19; Coronavirus disease-2019; Clinical trials; SARS-CoV-2; Adverse effects of hydroxychloroquine; Pharmacovigilance concern