bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimating the risk of arbovirus transmission in Southern Europe using vector competence data
Authors: Mariconti Marina , Obadia Thomas , Mousson Laurence , Malacrida Anna , Gasperi Giuliano , Failloux Anna-Bella , Yen Pei-Shi 
Published: November 2019

AbstractArboviral diseases such as chikungunya, dengue, and Zika viruses have been threatening the European countries since the introduction in 1979 of the major vectorAedes albopictus. In 2017, more than three hundred of CHIKV autochthonous cases were reported in Italy, highlighting the urgent need for a risk assessment of arboviral diseases in European countries. In this study, the vector competence for three major arboviruses were analyzed in eightAe.albopictuspopulations from Europe. Here we show that Southern EuropeanAe.albopictuswere susceptible to CHIKV, DENV-1 and ZIKV with the highest vector competence for CHIKV. Based on vector competence data and vector distribution, a prediction risk map for CHIKV was generated stressing the fear of CHIKV and to a lesser extent, of other arboviruses for Europe, calling us for new public health strategies.
Feasibility study of finalizing the extended adjuvant temozolomide based on methionine positron emission tomography (Met-PET) findings in patients with glioblastoma
Authors: Hirono Seiichiro , Hasegawa Yuzo , Sakaida Tsukasa , Uchino Yoshio , Hatano Kazuo , Iuchi Toshihiko 
Published: November 2019

AbstractIn the management of patients with newly diagnosed glioblastoma, there is no standard duration for adjuvant temozolomide treatment. This study aimed to assess the feasibility of finalizing adjuvant temozolomide treatment on the basis of methionine uptake in methionine positron emission tomography (Met-PET). We conducted a retrospective review of glioblastoma patients who underwent more than twelve cycles of temozolomide (extended temozolomide) treatment after resection and concomitant chemoradiotherapy with no evidence of recurrence on MRI. In addition to the methionine uptake value at the completion of extended temozolomide, local and distant recurrence and progression-free survival were also analyzed. Forty-four patients completed the extended temozolomide treatment. Among these, 18 experienced some type of tumor recurrence within one year. A Tmax/Nave value of 2.0 was the optimal cut-off value indicating progression. More than 80% of the patients with low methionine uptake completed the temozolomide treatment, and subsequent basic MRI observations showed no recurrence within one year after Met-PET. Subgroups with high uptake (≥2.0), even with continuation of temozolomide treatment, showed more frequent tumor progression than patients with low uptake (<2.0) who completed the extended temozolomide treatment (p < 0.001, odds ratio 14.7, 95% CI 3.46–62.3). The tumor recurrence rate increased in stepwise manner according to methionine uptake. Finalization of the extended temozolomide treatment on the basis of low uptake value was feasible with a low recurrence rate. Compared to MRI, Met-PET shows better ability to predict tumor progression in long-term glioblastoma survivors with extended temozolomide use.
The effect of 5 alpha-reductase inhibitor therapy on prostate cancer detection in the era of multi-parametric magnetic resonance imaging
Authors: Kim Jung Kwon , Lee Hak Jong , Hwang Sung Il , Choe Gheeyoung , Kim Hak Ju , Hong Sung Kyu 
Published: November 2019

AbstractWe aimed to evaluate the effect of 5 alpha-reductase inhibitor (5-ARI) treatment on prostate cancer (PCa) and clinically significant PCa (csPCa) detection in patients undergoing transrectal ultrasound (TRUS)/magnetic resonance imaging (MRI) fusion biopsy in the current era of multi-parametric MRI (mpMRI). We retrospectively reviewed our TRUS/MRI fusion biopsy database (n = 706). Eighty (11.3%) patients who had used 5-ARI for more than one year at the time of biopsy were stratified as 5-ARI group. Subsequently, we performed comparative analyses of 5-ARI and non-5-ARI groups. csPCa was defined by a Gleason score ≥3 + 4 in a single biopsy core. Chi-squared test was used to evaluate the performance of mpMRI in predicting PCa/csPCa between the two groups. Multivariate logistic regression analyses were performed to evaluate the significant variables associated with PCa detection. There were no significant differences in PCa/csPCa detection rates between 5-ARI and non-5-ARI groups (all, P > 0.05). In multivariate logistic regression analyses for the evaluation of variables associated with csPCa detection, age (odds ratio [OR], 1.062; 95% confidence interval [CI], 1.035–1.090; P < 0.001), pre-biopsy PSA (OR, 1.062; 95% CI, 1.034–1.090; P < 0.001), prostate volume on TRUS (OR, 0.956; 95% CI, 0.943–0.970, P < 0.001), and PI-RADsV2 category (OR, 5.528; 95% CI, 3.017–10.131; P < 0.001) were found to be significant predictors. However, 5-ARI had no significant association with PCa detection (P = 0.384). Conclusively, 5-ARI therapy did not adversely affect PCa/csPCa detection after TRUS/MRI fusion biopsy, which suggests that exposure to 5-ARI may not impair the performance of mpMRI.
Bevacizumab for the treatment of non-small cell lung cancer patients with synchronous brain metastases
Authors: Ascha Mustafa S. , Wang Jacqueline Fang , Kumthekar Priya , Sloan Andrew E. , Kruchko Carol , Barnholtz-Sloan Jill S. 
Published: November 2019

AbstractBevacizumab is FDA-approved in the treatment of primary brain tumors, but its efficacy in patients with brain metastases could be better-studied. This study examines a population of non-small cell lung cancer (NSCLC) patients with synchronous brain metastases to identify predictors of the decision to use bevacizumab and survival following bevacizumab treatment. Primary cancer registry data were used to determine which NSCLC patients diagnosed in the years 2010 through 2012 had synchronous brain metastases at the time of diagnosis, and Medicare claims used to identify a population of patients treated with bevacizumab. Record of bevacizumab treatment was found for 81 and 666 patients with and without brain metastases, respectively. After adjusting for clinical and demographic characteristics, bevacizumab was associated with 0.88 times the hazard of mortality in the elderly NSCLC population (95% CI: 0.81–0.96, p: 0.003) and a corresponding hazard ratio of 0.75 in the population of elderly NSCLC patients with synchronous brain metastases (95% CI: 0.59–0.96, p: 0.020). Bevacizumab may benefit NSCLC patients with synchronous brain metastases more than it does patients without intracranial disease, possibly as a result of its multiple potential mechanisms of action simultaneously inhibiting angiogenesis and minimizing vasogenic edema.
HuoXue QianYang QuTan Recipe attenuates left ventricular hypertrophy in obese hypertensive rats by improving mitochondrial function through SIRT1/PGC-1α deacetylation pathway
Authors: Wang Jing , Dong Zhen-Hua , Gui Ming-Tai , Yao Lei , Li Jian-Hua , Zhou Xun-Jie , Fu De-Yu 
Published: November 2019

Abstract
Mitochondrial dysfunction plays a vital role in the progression of left ventricular hypertrophy (LVH). Previous studies have confirmed that the disorder of SIRT1/PGC-1α deacetylation pathway aggravated mitochondrial dysfunction. HuoXue QianYang QuTan Recipe (HQQR) is a commonly used prescription that has shown therapeutic effects on obesity hypertension and its complications. However, the potential mechanisms are still unclear. In the present study, obesity hypertension (OBH) was established in rats and we investigated the efficacy and mechanisms of HQQR on LVH. Rats were divided into the five groups: (1) WKY-ND group, (2) SHR-ND group, (3) OBH-HF group, (4) OBH-HF/V group and (5) OBH-HF/H group. We evaluated body weight, Lee index and blood pressure (BP) before and every 2 weeks after treatment. After 10 weeks of treatment, we mainly detected glycolipid metabolic index, the severity of LVH, mitochondrial function along with SIRT1/PGC-1α deacetylation pathway. Our results showed that HQQR significantly lowered body weight, Lee index, BP and improved the disorder of glycolipid metabolism in OBH rats. Importantly, we uncovered HQQR could alleviate mitochondrial dysfunction in OBH rats by regulating SIRT1/PGC-1α deacetylation pathway. These changes could be associated with the inhibition of LVH.
The extended molecular envelope of the asymptotic giant branch star π1 Gruis as seen by ALMA
Authors: Doan L. , Ramstedt S. , Vlemmings W. H. T. , Mohamed S. , Höfner S. , De Beck E. , Kerschbaum F. , Lindqvist M. , Maercker M. , Paladini C. , Wittkowski M. 
Published: November 2019

Context. This study is a follow up to the previous analysis of lower-angular resolution data in which the kinematics and structure of the circumstellar envelope (CSE) around the S-type asymptotic giant branch (AGB) star π1 Gruis were investigated. The AGB star has a known companion (at a separation of ~400 AU) that cannot explain the strong deviations from spherical symmetry of the CSE. Recently, hydrodynamic simulations of mass transfer in closer binary systems have successfully reproduced the spiral-shaped CSEs found around a handful of sources. There is growing evidence for an even closer, undetected companion complicating the case of π1 Gruis further.
Aims. The improved spatial resolution allows for the investigation of the complex circumstellar morphology and the search for imprints on the CSE of the third component.
Methods. We have observed the 12CO J = 3–2 line emission from π1 Gruis using both the compact and extended array of Atacama Large Millimeter/submillimeter Array (ALMA). The interferometric data have furthermore been combined with data from the ALMA total power array. The imaged brightness distribution has been used to constrain a non-local, non-local thermodynamic equilibrium 3D radiative transfer model of the CSE.
Results. The high-angular resolution ALMA data have revealed the first example of a source on the AGB where both a faster bipolar outflow and a spiral pattern along the orbital plane can be seen in the gas envelope. The spiral can be traced in the low- to intermediate-velocity (13–25 km s−1) equatorial torus. The largest spiral-arm separation is ≈5.′′5 and consistent with a companion with an orbital period of ≈330 yr and a separation of less than 70 AU. The kinematics of the bipolar outflow is consistent with it being created during a mass-loss eruption where the mass-loss rate from the system increased by at least a factor of five for 10–15 yr.
Conclusions. The spiral pattern is the result of an undetected companion. The bipolar outflow is the result of a rather recent mass-loss eruption event.
Revisiting the cosmic-ray induced Venusian radiation dose in the context of habitability
Authors: Herbst Konstantin , Banjac Saša , Atri Dimitra , Nordheim Tom A. 
Published: November 2019

Context. Cosmic rays (CRs), which constantly bombard planetary magnetic fields and atmospheres, are the primary driver of atmospheric spallation processes. The higher the energy of these particles, the deeper they penetrate the planetary atmosphere, and the more likely interactions become with the ambient atmospheric material and the evolution of secondary particle showers.
Aims. As recently discussed in the literature, CRs are the dominant driver of the Venusian atmospheric ionization and the induced radiation dose below ~100 km. In this study, we model the atmospherically absorbed dose and the dose equivalent to the effect of cosmic rays in the context of Venusian habitability.
Methods. The Atmospheric Radiation Interaction Simulator was used to model the altitude-dependent Venusian absorbed dose and the Venusian dose equivalent. For the first time, we modeled the dose rates for different shape-, size-, and composition-mimicking detectors (phantoms): a CO2-based phantom, a water-based microbial cell, and a phantom mimicking human tissue.
Results. Based on our new model approach, we give a reliable estimate of the altitude-dependent Venusian radiation dose in water-based microorganisms here for the first time. These microorganisms are representative of known terrestrial life. We also present a detailed analysis of the influence of the strongest ground-level enhancements measured at the Earth’s surface, and of the impact of two historic extreme solar events on the Venusian radiation dose. Our study shows that because a phantom based on Venusian air was used, and because furthermore, the quality factors of different radiation types were not taken into account, previous model efforts have underestimated the radiation hazard for any putative Venusian cloud-based life by up to a factor of five. However, because we furthermore show that even the strongest events would not have had a hazardous effect on putative microorganisms within the potentially habitable zone (51–62 km), these differences may play only a minor role.
Proximal Femoral Osteotomies in the Adolescence: Indications and Treatment Strategies
Authors: Ploeger Milena M. , Gathen Martin , Struwe Charlotte , Placzek Richard 
Published: November 2019

AbstractProximal femoral osteotomies are common surgical interventions to treat hip deformities in pediatric orthopedics. The aim of proximal femoral osteotomies is to optimise hip containment by using varus or valgus osteotomy, flexion or extension osteotomy with shortening, lengthening or derotation of the femoral neck. Furthermore improved muscular dysbalance by enhancing the femoral offset, extension of the range of motion and pain reduction are important surgical intentions. In the long term, a proximal femoral osteotomy is meant to minimize the probability of an early osteoarthritis of the hip. In the current literature many different types of proximal femoral osteotomies are described. They can be divided concerning their anatomical localization into subcapital, base of the femoral neck, intertrochanteric and subtrochanteric osteotomies. A profound knowledge about the deformity and the anatomical situation is essential to choose the appropriate osteotomy. The aim of this
review is to show the different ways of proximal femoral osteotomies and their indications after having done a selective literature research. Furthermore over the last years the osteosynthesis materials have changed from blade plates (non-locking) to locking compression plates which allow an early re-mobilization without hip spica casts.
ERNICA Consensus Conference on the Management of Patients with Esophageal Atresia and Tracheoesophageal Fistula: Follow-up and Framework
Authors: Dingemann Carmen , Eaton Simon , Aksnes Gunnar , Bagolan Pietro , Cross Kate M. , De Coppi Paolo , Fruithof JoAnne , Gamba Piergiorgio , Husby Steffen , Koivusalo Antti , Rasmussen Lars , Sfeir Rony , Slater Graham , Svensson Jan F. , Van der Zee David C. , Wessel Lucas M. , Widenmann-Grolig Anke , Wijnen Rene , Ure Benno M. 
Published: November 2019

Abstract
Introduction Improvements in care of patients with esophageal atresia (EA) and tracheoesophageal fistula (TEF) have shifted the focus from mortality to morbidity and quality-of-life. Long-term follow-up is essential, but evidence is limited and standardized protocols are scarce. Nineteen representatives of the European Reference Network for Rare Inherited Congenital Anomalies (ERNICA) from nine European countries conducted a consensus conference on the surgical management of EA/TEF.
Materials and Methods The conference was prepared by item generation (including items of surgical relevance from the European Society for Pediatric Gastroenterology Hepatology and Nutrition (ESPGHAN)-The North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) guidelines on follow-up after EA repair), item prioritization, formulation of a final list containing the domains Follow-up and Framework, and literature review. Anonymous voting was conducted via an internet-based system. Consensus was defined as ≥75% of those voting with scores of 6 to 9.
Results Twenty-five items were generated in the domain Follow-up of which 17 (68%) matched with corresponding ESPGHAN-NASPGHAN statements. Complete consensus (100%) was achieved on seven items (28%), such as the necessity of an interdisciplinary follow-up program. Consensus ≥75% was achieved on 18 items (72%), such as potential indications for fundoplication. There was an 82% concordance with the ESPGHAN-NASPGHAN recommendations. Four items were generated in the domain Framework, and complete consensus was achieved on all these items.
Conclusion Participants of the first ERNICA conference reached significant consensus on the follow-up of patients with EA/TEF who undergo primary anastomosis. Fundamental statements regarding centralization, multidisciplinary approach, and involvement of patient organizations were formulated. These consensus statements will provide the cornerstone for uniform treatment protocols and resultant optimized patient care.
Contemporary Knee Osteotomy in the United States: High Tibial Osteotomy and Distal Femoral Osteotomy Have Comparable Complication Rates despite Differing Demographic Profiles
Authors: Delva Mona Lisa , Samuel Linsen T. , Roth Alexander , Yalçin Sercan , Kamath Atul F. 
Published: November 2019

AbstractKnee osteotomies show efficacy in slowing knee osteoarthritis progression and delaying the need for total knee arthroplasty in younger patients. Despite evolutions in indications, techniques, and hardware that have improved outcomes, longitudinal trends demonstrate a decline in high tibial osteotomy (HTO) and distal femoral osteotomy (DFO) use. Unfortunately, knowledge of the current usage and complications associated with HTO and DFO is limited. The purpose of this study was to compare the preoperative demographics and early complication rates of HTO and DFO. We analyzed the HTOs and DFOs performed between 2006 and 2017 using the ACS-NSQIP (American College of Surgeons National Surgical Quality Improvement Program) database. We compared both groups for preoperative patient demographics (sex, age, race, body mass index [BMI]) and health status variables including functional scores, ASA (American Society of Anesthesiologists) scores, smoking status, and other comorbidities. Emergency and elective status of the patient case, length of hospital stay, operation time, and 30-day postoperative complications were also analyzed. After the exclusion criteria were applied, 321 HTO and 295 DFO patients were included in the final analysis. The HTO group had higher proportions of younger (p < 0.001) and male (p < 0.001) patients with higher BMI (p = 0.007). Racial profiles were similar between the two groups (p = 0.575). Preoperatively, those in the HTO group had more functional independence, better physical status scores, and fewer chronic conditions (p < 0.05). There were no statistically significant differences between HTO and DFO in operative time, postoperative complications, readmission, and reoperation. HTO patients, however, had shorter hospital stays (p < 0.001). Although there are differences in preoperative and operative characteristics of HTO and DFO, early postoperative complications are similar for both groups. Therefore, HTO and DFO can be considered safe and effective treatment options for younger patients with symptomatic unicompartmental knee osteoarthritis.
Diagnostic Value of Clinical and Laboratory Findings in Childhood Meningitis
Authors: Emiroglu Melike , Kesli Recep , Kilicaslan Murat 
Published: November 2019

Abstract
Objective Acute meningitis in childhood is a serious infectious disease that requires immediate medical assessment to ensure appropriate treatment and healthy outcomes. The aim of this retrospective study was to evaluate clinical and laboratory findings in the diagnosis of acute meningitis in children.
Materials and Methods Between February 2011 and March 2013, 258 children aged between 1 month and 18 years who were admitted to Konya Training and Research Hospital, Turkey, with clinically suspected meningitis and undergoing lumbar puncture were enrolled in the study. Patient charts were reviewed using a standardized data collection tool. Fifty-nine patients were excluded because of incomplete data or because they did not meet the enrollment criteria. Further statistical analysis was conducted on the remaining 199 patients. The diagnostic values of clinical and laboratory findings for acute meningitis were investigated. IBM SPSS 21.0 for Windows was used for the statistical analysis.
Results Of the 199 patients (61.3% male; median age: 24 months), 101 (50.8%) were diagnosed with meningitis. A definitive diagnosis of bacterial meningitis was made in 16 patients, while 5 patients had probable bacterial meningitis. In addition, 80 patients diagnosed as aseptic meningitis and 47 of these patients had human enterovirus meningitis. Headache was more common in patients with meningitis. In patients without meningitis, the most common complaints were seizures or seizures accompanied by fever. Erythrocyte sedimentation rates (ESR), levels of cerebrospinal fluid protein, and cell counts in cerebrospinal fluid examinations were higher in the meningitis group. C-reactive protein, ESR, and procalcitonin higher than 22.55 mg/L, 36.5 mm/hour, and 6.795 mg/mL, respectively, indicated bacterial meningitis.
Conclusion Our results showed that a combination of clinical and laboratory markers could facilitate recognition of bacterial meningitis in children.
Tone Reduction and Physical Therapy: Strengthening Partners in Treatment of Children with Spastic Cerebral Palsy
Authors: Franki Inge , Bar-On Lynn , Molenaers Guy , Van Campenhout Anja , Craenen Karen , Desloovere Kaat , Feys Hilde , Pauwels Petra , De Cat Jos , Ortibus Els 
Published: November 2019

AbstractThe aim of this paper is to provide a clinically applicable overview of different tone reducing modalities and how these can interact with or augment concurrent physical therapy (PT). Botulinum toxin (BoNT), oral tone-regulating medication, intrathecal baclofen (ITB), and selective dorsal rhizotomy are discussed within a physiotherapeutic context and in view of current scientific evidence. We propose clinical reasoning strategies to identify treatment goals as well as the appropriate and corresponding treatment interventions. Instrumented measurement of spasticity, standardized clinical assessment, and 3D clinical motion analysis are scientifically sound tools to help select the appropriate treatment and, when needed, to selectively target or spare individual muscles. In addition, particular attention is given to strength training as a necessary tool to tackle muscle weakness associated with specific modalities of tone reduction. More research is needed to methodologically assess the long-term effectiveness of such individualized tone treatment, optimize parameters such as medication dosage, and gain more insight into the kind of PT techniques that are essential in conjunction with tone reduction.
Double superior vena cava and variation in pulmonary venous drainage - case report
Authors: M. Chimmalgi , P. Rangsubhe , S. Shanu , LV Amalasmitha , Krishnan Kavya , S. Dhanushia , Sarkar Sanju 
Published: November 2019

AbstractDuring routine dissection for undergraduate students, two venous end cardiac anomalies were noted In a male cadaver, in addition to a normal right sided superior vena cava, a persistent left superior vena cava (PLSVC) was seen opening into the right atrium via coronary sinus. Left brachiocephalic vein was of a small caliber. In addition, left atrium showed only two pulmonary ostia. No other cardiac anomalies were found Both these anomalies rarely cause any haemo-dynamic compromise and hence may remain asymptomatic throughout life. They are usually found as a chance finding during imaging studies or in post mortem studies as was seen in this case. However, both are known to be associated with cardiac arrhythmias. Their concomitant occurrence suggests a common timing of their development and / or a common causative agent that halted their development. Knowledge of these anomalies is invaluable for the cardiac surgeons and interventionists.