bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantifying Contributions of Internal Variability and External Forcing to Atlantic Multidecadal Variability Since 1870
Authors: Qin Minhua , Dai Aiguo , Hua Wenjian 
Published: October 2020

AbstractIdentifying the mechanisms behind the Atlantic Multidecadal Variability (AMV) is crucial for understanding and predicting decadal climate change. However, what is behind the AMV is still debated. A key issue is the relative role of internal variability (IV) and external forcing in causing the AMV. By analyzing observations and a large number of climate model simulations, here we show that IV and volcanic and anthropogenic aerosols all influenced the AMV over the last ~150 years. Although the AMV since 1870 resulted mainly from IV, decadal variations in aerosol forcing happen to be in phase with the IV‐induced AMV and thus enlarged its amplitudes, especially since the late 1920s. Our results support the notion that the AMV resulted from both internal climate variability and decadal changes in aerosols but are inconsistent with the conclusion that the recent AMV is mainly a direct response to external forcing.
Wind Speed, Surface Flux, and Intraseasonal Convection Coupling From CYGNSS Data
Authors: Bui Hien X. , Maloney Eric D. , Riley Dellaripa Emily M. , Singh Bohar 
Published: October 2020

AbstractThis study analyzes wind speed and surface latent heat flux anomalies from the Cyclone Global Navigation Satellite System (CYGNSS), aiming to understand the physical mechanisms regulating intraseasonal convection, particularly associated with the Madden‐Julian oscillation (MJO). An advantage of CYGNSS compared to other space‐based data sets is that its surface wind speed retrievals have reduced attenuation by precipitation, thus providing improved information about the importance of wind‐induced surface fluxes for the maintenance of convection. Consistent with previous studies from buoys, CYGNSS shows that enhanced MJO precipitation is associated with enhanced wind speeds, and that associated surface heat flux anomalies have a magnitude about 7–12% of precipitation anomalies. Thus, latent heat flux anomalies are an important maintenance mechanism for MJO convection through the column moist static energy budget. A composite analysis during boreal summer over the eastern north Pacific also supports the idea that wind‐induced surface flux is important for MJO maintenance there.
ARTEMIS Observations of Foreshock Transients in the Midtail Foreshock
Authors: Liu Terry Z. , Wang Chih‐Ping , Wang Boyi , Wang Xueyi , Zhang Hui , Lin Yu , Angelopoulos Vassilis 
Published: October 2020

AbstractForeshock transients such as hot flow anomalies (HFAs) are frequently observed in the dayside foreshock. They can disturb the local bow shock, magnetopause, and consequently the magnetosphere‐ionosphere system through dynamic pressure perturbations. Recent multipoint observations found that such perturbations can even propagate from the dayside to the midtail. However, whether the drivers of such perturbations, foreshock transients, persist in the midtail foreshock has not been observed. Thus, it is unclear whether the observed nightside magnetosheath/magnetopause perturbations are traveling waves or continuously driven by a propagating foreshock transient. Using two Acceleration, Reconnection, Turbulence, and Electrodynamics of the Moon's Interaction with the Sun (ARTEMIS) spacecraft, we report direct observational evidence of foreshock transients in the midtail foreshock. We present a case study showing an elongated mature HFA propagating with its driver discontinuity from TH‐C (X ~ −43 RE) to TH‐B (X ~ −48 RE). Our results confirm that foreshock transients disturb not only the dayside bow shock but also the nightside bow shock while propagating tailward.
Genome-wide CRISPR screen identifies LGALS2 as an oxidative stress-responsive gene with an inhibitory function on colon tumor growth
Authors: Li Haiwen , Zhao Lixia , Lau Yeh Siang , Zhang Chen , Han Renzhi 
Published: October 2020

AbstractColorectal cancer is the third leading cause of cancer-related deaths in the United States and the third most common cancer in men and women. Around 20% colon cancer cases are closely linked with colitis. Both environmental and genetic factors are thought to contribute to colon inflammation and tumor development. However, the genetic factors regulating colitis and colon tumorigenesis remain elusive. Since reactive oxygen species (ROS) is vitally involved in tissue inflammation and tumorigenesis, here we employed a genome-wide CRISPR knockout screening approach to systemically identify the genetic factors involved in the regulation of oxidative stress. Next generation sequencing (NGS) showed that over 600 gRNAs including the ones targetingLGALS2were highly enriched in cells survived after sublethal H2O2challenge.LGALS2encodes the glycan-binding protein Galectin 2 (Gal2), which is predominantly expressed in the gastrointestinal tract and downregulated in human colon tumors. To examine the role of Gal2 in colitis, we employed the dextran sodium sulfate (DSS)-induced acute colitis model in mice with (WT) or withoutLgals2(Gal2-KO) and showed that Gal2 deficiency ameliorated DSS-induced colitis. We further demonstrated that Gal2-KO mice developed significantly larger tumors than WT mice using Azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colorectal cancer model. We found that STAT3 phosphorylation was significantly increased in Gal2-deficient tumors as compared to those in WT mice. Gal2 overexpression decreased the proliferation of human colon tumor epithelial cells and blunted H2O2-induced STAT3 phosphorylation. Overall, our results demonstrate that Gal2 plays a suppressive role in colon tumor growth and highlights the therapeutic potential of Gal2 in colon cancer.
Individual back-calculated size-at-age based on otoliths from Pacific coral reef fish species
Authors: Morat Fabien , Wicquart Jérémy , Schiettekatte Nina M. D. , de Sinéty Guillemette , Bienvenu Jean , Casey Jordan M. , Brandl Simon J. , Vii Jason , Carlot Jérémy , Degregori Samuel , Mercière Alexandre , Fey Pauline , Galzin René , Letourneur Yves , Sasal Pierre , Parravicini Valeriano 
Published: October 2020

AbstractSomatic growth is a critical biological trait for organismal, population, and ecosystem-level processes. Due to its direct link with energetic demands, growth also represents an important parameter to estimate energy and nutrient fluxes. For marine fishes, growth rate information is most frequently derived from sagittal otoliths, and most of the available data stems from studies on temperate species that are targeted by commercial fisheries. Although the analysis of otoliths is a powerful tool to estimate individual growth, the time-consuming nature of otolith processing is one barrier for collection of comprehensive datasets across multiple species. This is especially true for coral reef fishes, which are extremely diverse. Here, we provide back-calculated size-at-age estimates (including measures of uncertainty) based on sagittal otoliths from 710 individuals belonging to 45 coral reef fish species from French Polynesia. In addition, we provide Von Bertalanffy growth parameters which are useful to predict community level biomass production.
Nanofluid flow with autocatalytic chemical reaction over a curved surface with nonlinear thermal radiation and slip condition
Authors: Ramzan Muhammad , Rafiq Abida , Chung Jae Dong , Kadry Seifedine , Chu Yu-Ming 
Published: October 2020

AbstractThe study of nanofluids is the most debated subject for the last two decades. Researchers have shown great interest owing to the amazing features of nanofluids including heat transfer and thermal conductivity enhancement capabilities. Having such remarkable features of nanofluids in mind we have envisioned a mathematical model that discusses the flow of nanofluid comprising Nickel-Zinc Ferrite-Ethylene glycol (Ni-ZnFe2O4–C2H6O2) amalgamation past an elongated curved surface with autocatalytic chemical reaction. The additional impacts added to the flow model are the heat generation/absorption with nonlinear thermal radiation. At the boundary, the slip and the convective conditions are added. Pertinent transformations are affianced to get the system of ordinary differential equations from the governing system in curvilinear coordinates. A numerical solution is found by applying MATLAB build-in function bvp4c. Graphical illustrations and the numerically computed estimates are discussed and analyzed properly. It is comprehended that velocity and temperature distributions have varied trends near and away from the curve when the curvature parameter is enhanced. Further, it is comprehended that the concentration field declines for both homogeneous and heterogeneous reaction parameters.
Assessing the prognostic value of stemness-related genes in breast cancer patients
Authors: Wang Wen-Jie , Wang Han , Wang Meng-sen , Huang Yue-Qing , Ma Yu-Yuan , Qi Jie , Shi Jian-Ping , Li Wei 
Published: October 2020

AbstractBreast cancer (BC) is currently one of the deadliest tumors worldwide. Cancer stem cells (CSCs) are a small group of tumor cells with self-renewal and differentiation abilities and high treatment resistance. One of the reasons for treatment failures is the inability to completely eliminate tumor stem cells. By using the edgeR package, we identified stemness-related differentially expressed genes in GSE69280. Via Lasso-penalized Cox regression analysis and univariate Cox regression analysis, survival genes were screened out to construct a prognostic model. Via nomograms and ROC curves, we verified the accuracy of the prognostic model. We selected 4 genes (PSMB9, CXCL13, NPR3, and CDKN2C) to establish a prognostic model from TCGA data and a validation model from GSE24450 data. We found that the low-risk score group had better OS than the high-risk score group, whether using TCGA or GSE24450 data. A prognostic model including four stemness-related genes was constructed in our study to determine targets of breast cancer stem cells (BCSCs) and improve the treatment effect.
A role for the immune system in advanced laryngeal cancer
Authors: Tagliabue Marta , Maffini Fausto , Fumagalli Caterina , Gandini Sara , Lepanto Daniela , Corso Federica , Cacciola Salvatore , Ranghiero Alberto , Rappa Alessandra , Vacirca Davide , Cossu Rocca Maria , Alterio Daniela , Guerini Rocco Elena , Cattaneo Augusto , Chu Francesco , Zorzi Stefano , Curigliano Giuseppe , Chiocca Susanna , Barberis Massimo , Viale Giuseppe , Ansarin Mohssen 
Published: October 2020

AbstractTo investigate the role of the altered activation of the immune system in the prognosis of patients affected by laryngeal squamous cell carcinoma (LSCC). We analyzed 56 patients with advanced LSCC divided into two groups according to their prognosis: the first group relapsed within 24 months after treatment, the second group had no evidence of disease at 2 years. The presence of stromal tumor infiltrating lymphocytes (TILs) at the tumor-host border was investigated. In 43 patients we evaluated the expression of 395 genes related to immune system activation through a next generation sequencing panel. Priority-LASSO models and clustering analyses were integrated with multivariate Cox proportional hazard modeling to identify independent genes associated with relapse and estimate hazard ratios in relation to gene expression and TILs. TILs and the expression of genes related with immune system activation (FCGR1A, IFNA17, FCRLA, NCR3, KREMEN1, CD14, CD3G, CD19, CD20 and CD79A) were significantly associated with prognostic factors or disease specific survival. In patients with lymph node metastases and advanced T stage (pT4), the expression of other genes was altered. Low TILs count was highly associated with relapse within 2 years (p < 0.001). Low TILs and altered expression of specific genes associated with tumor-immune systems interactions emerged as independent risk factors, associated to poor prognosis and relapse within 2 years in advanced LSCC. Evaluation of patients’ immune profile could be useful for prognosis and future therapeutic approaches towards personalized therapy.
Atherosclerotic plaque vulnerability is increased in mouse model of lupus
Authors: Santiago-Raber Marie-Laure , Montecucco Fabrizio , Vuilleumier Nicolas , Miteva Kapka , Baptista Daniela , Carbone Federico , Pagano Sabrina , Roth Aline , Burger Fabienne , Mach Francois , Brandt Karim J. 
Published: October 2020

AbstractAnti-apolipoprotein A-1 (anti-apoA-1 IgG) and anti-double stranded DNA (anti-dsDNA IgG) autoantibodies have been described as mediators of atherogenesis in mice and humans. In the present study, we aim to investigate the association between atherosclerotic parameters, autoantibodies and plaque vulnerability in the context of systemic lupus erythematosus (SLE). We therefore bred a lupus prone-mouse model (Nba2.Yaa mice) with Apoe−/− mice resulting in Apoe−/−Nba2.Yaa mice spontaneously producing anti-apoA-1 IgG antibodies. Although Apoe−/−Nba2.Yaa and Apoe−/− mice subject to a high cholesterol diet displayed similar atherosclerosis lesions size in aortic roots and abdominal aorta, the levels of macrophage and neutrophil infiltration, collagen, MMP-8 and MMP-9 and pro-MMP-9 expression in Apoe−/−Nba2.Yaa mice indicated features of atherosclerotic plaque vulnerability. Even though Apoe−/−Nba2.Yaa mice and Apoe−/− mice had similar lipid levels, Apoe−/−Nba2.Yaa mice showed higher anti-apoA-1 and anti-dsDNA IgG levels. Apoe−/−Nba2.Yaa mice displayed a reduction of the size of the kidney, splenomegaly and lymph nodes (LN) hypertrophy. In addition, anti-apoA-1 and anti-dsDNA IgG increased also in relation with mRNA levels of GATA3, IL-4, Bcl-6 and CD20 in the spleen and aortic arch of Apoe−/−Nba2.Yaa mice. Our data show that although atherosclerosis-lupus-prone Apoe−/−Nba2.Yaa mice did not exhibit exacerbated atherosclerotic lesion size, they did show features of atherosclerotic plaque destabilization in correlation with the increase of pro-atherogenic autoantibodies.
Distributed changes of the functional connectome in patients with glioblastoma
Authors: Nenning Karl-Heinz , Furtner Julia , Kiesel Barbara , Schwartz Ernst , Roetzer Thomas , Fortelny Nikolaus , Bock Christoph , Grisold Anna , Marko Martha , Leutmezer Fritz , Liu Hesheng , Golland Polina , Stoecklein Sophia , Hainfellner Johannes A. , Kasprian Gregor , Prayer Daniela , Marosi Christine , Widhalm Georg , Woehrer Adelheid , Langs Georg 
Published: October 2020

AbstractGlioblastoma might have widespread effects on the neural organization and cognitive function, and even focal lesions may be associated with distributed functional alterations. However, functional changes do not necessarily follow obvious anatomical patterns and the current understanding of this interrelation is limited. In this study, we used resting-state functional magnetic resonance imaging to evaluate changes in global functional connectivity patterns in 15 patients with glioblastoma. For six patients we followed longitudinal trajectories of their functional connectome and structural tumour evolution using bi-monthly follow-up scans throughout treatment and disease progression. In all patients, unilateral tumour lesions were associated with inter-hemispherically symmetric network alterations, and functional proximity of tumour location was stronger linked to distributed network deterioration than anatomical distance. In the longitudinal subcohort of six patients, we observed patterns of network alterations with initial transient deterioration followed by recovery at first follow-up, and local network deterioration to precede structural tumour recurrence by two months. In summary, the impact of focal glioblastoma lesions on the functional connectome is global and linked to functional proximity rather than anatomical distance to tumour regions. Our findings further suggest a relevance for functional network trajectories as a possible means supporting early detection of tumour recurrence.
Anthropogenic emissions from South Asia reverses the aerosol indirect effect over the northern Indian Ocean
Authors: Jose Subin , Nair Vijayakumar S. , Babu S. Suresh 
Published: October 2020

AbstractAtmospheric aerosols play an important role in the formation of warm clouds by acting as efficient cloud condensation nuclei (CCN) and their interactions are believed to cool the Earth-Atmosphere system (‘first indirect effect or Twomey effect’) in a highly uncertain manner compared to the other forcing agents. Here we demonstrate using long-term (2003–2016) satellite observations (NASA’s A-train satellite constellations) over the northern Indian Ocean, that enhanced aerosol loading (due to anthropogenic emissions) can reverse the first indirect effect significantly. In contrast to Twomey effect, a statistically significant increase in cloud effective radius (CER, µm) is observed with respect to an increase in aerosol loading for clouds having low liquid water path (LWP < 75 g m−2) and drier cloud tops. Probable physical mechanisms for this effect are the intense competition for available water vapour due to higher concentrations of anthropogenic aerosols and entrainment of dry air on cloud tops. For such clouds, cloud water content showed a negative response to cloud droplet number concentrations and the estimated intrinsic radiative effect suggest a warming at the Top of the Atmosphere. Although uncertainties exist in quantifying aerosol-cloud interactions (ACI) using satellite observations, present study indicates the physical existence of anti-Twomey effect over the northern Indian Ocean during south Asian outflow.
Quercetin inhibits virulence properties of Porphyromas gingivalis in periodontal disease
Authors: He Zhiyan , Zhang Xu , Song Zhongchen , Li Lu , Chang Haishuang , Li Shiliang , Zhou Wei 
Published: October 2020

AbstractPorphyromonas gingivalis is a causative agent in the onset and progression of periodontal disease. This study aims to investigate the effects of quercetin, a natural plant product, on P. gingivalis virulence properties including gingipain, haemagglutinin and biofilm formation. Antimicrobial effects and morphological changes of quercetin on P. gingivalis were detected. The effects of quercetin on gingipains activities and hemolytic, hemagglutination activities were evaluated using chromogenic peptides and sheep erythrocytes. The biofilm biomass and metabolism with different concentrations of quercetin were assessed by the crystal violet and MTT assay. The structures and thickness of the biofilms were observed by confocal laser scanning microscopy. Bacterial cell surface properties including cell surface hydrophobicity and aggregation were also evaluated. The mRNA expression of virulence and iron/heme utilization was assessed using real time-PCR. Quercetin exhibited antimicrobial effects and damaged the cell structure. Quercetin can inhibit gingipains, hemolytic, hemagglutination activities and biofilm formation at sub-MIC concentrations. Molecular docking analysis further indicated that quercetin can interact with gingipains. The biofilm became sparser and thinner after quercetin treatment. Quercetin also modulate cell surface hydrophobicity and aggregation. Expression of the genes tested was down-regulated in the presence of quercetin. In conclusion, our study demonstrated that quercetin inhibited various virulence factors of P. gingivalis.
Demonstration of nearly pinhole-free epitaxial aluminum thin films by sputter beam epitaxy
Authors: Law Ka Ming , Budhathoki Sujan , Ranjit Smriti , Martin Franziska , Thind Arashdeep S. , Mishra Rohan , Hauser Adam J. 
Published: October 2020

AbstractSuperconducting resonators with high quality factors have been fabricated from aluminum films, suggesting potential applications in quantum computing. Improvement of thin film crystal quality and removal of void and pinhole defects will improve quality factor and functional yield. Epitaxial aluminum films with superb crystallinity, high surface smoothness, and interface sharpness were successfully grown on the c-plane of sapphire using sputter beam epitaxy. This study assesses the effects of varying substrate preparation conditions and growth and prebake temperatures on crystallinity and smoothness. X-ray diffraction and reflectivity measurements yield extensive Laue oscillations and Kiessig thickness fringes for films grown at 200 °C under 15 mTorr Ar, indicating excellent crystallinity and surface smoothness; moreover, an additional substrate preparation procedure which involves (1) a modified substrate cleaning procedure and (2) prebake at 700 °C in 20 mTorr O2 is shown by atomic force microscopy to yield nearly pinhole-free film growth while maintaining epitaxy and high crystal quality. The modified cleaning procedure is environmentally friendly and eliminates the acid etch steps common to conventional sapphire preparation, suggesting potential industrial application both on standard epitaxial and patterned surface sapphire substrates.
Pre-sarcopenia determines post-progression outcomes in advanced hepatocellular carcinoma after sorafenib failure
Authors: Cheng Tsung-Yi , Lee Pei-Chang , Chen Yi-Tzen , Chao Yee , Hou Ming-Chih , Huang Yi-Hsiang 
Published: October 2020

AbstractMany second-line therapies are recently approved for patients with advanced hepatocellular carcinoma (HCC), in whom protein malnutrition is prevalent that would affect treatment outcomes. In this study, we aimed to investigate the role of pre-sarcopenia and muscle restoration in patients with sorafenib-failed advanced HCC. From August 2012 to March 2017, 385 patients who developed radiology-proven HCC progression after sorafenib treatment were enrolled in the study. Pre-sarcopenia is defined as transverse psoas muscle thickness per body height < 16.8 mm/m, which was prevalent (64.7%) in our patients. Age > 60 years, female gender, and body mass index < 22 kg/m2 were independent predictors to the development of pre-sarcopenia. Patients with muscle depletion had significantly worse post-progression survival (PPS) compared with their counterparts (median PPS: 3.8 vs. 5.8 months, p = 0.003), particularly in those with intermediate liver reserves (Child–Pugh class B or Albumin-bilirubin grade 2). Besides, pre-sarcopenia independently predicted post-progression mortality in sorafenib-failed HCC (hazard ratio: 1.340, p = 0.012). In patients who developed pre-sarcopenia before sorafenib treatment, muscle restoration was associated with a longer PPS compared with their counterparts (6.3 vs. 3.6 months, p = 0.043). In conclusion, pre-sarcopenia independently determined the outcomes of sorafenib-failed HCC. Nutrition support to restore muscle mass would prolong survival for higher-risk patients.
Generation of plane spiral orbital angular momentum using circular double-slot Vivaldi antenna array
Authors: Zhu Yongzhong , Dang Weiguo , Liu Xiaoyu , Chen Yijun , Zhou Xiaofei , Lu Hongyan 
Published: October 2020

AbstractA novel and feasible solution to generate plane spiral orbital angular momentum (PSOAM) vortex beam is proposed in this paper. The general principle of generating PSOAM in circular antenna array (CAA) is deduced, and verified by the simulation of the dipole CAA. Four double-slot Vivaldi antenna elements connect sequentially and are inserted into a CAA, which makes the proposed antenna easily fabricated and fully miniaturized. Both simulated and measured results show that it can generate PSOAM with l = 3 (l is the mode number of vortex wave) at 5 GHz. The vortex phase of l = 3 is observed, the measured peak gain is 5.7 dB. The VSWR remains below 2 from 4 to 6 GHz, which shows the impedance bandwidth of S11 < −10 dB is more than 40%.