bluuebunny/crossref_metadata_2025_split huggingface dataset:
КЛІНІЧНИЙ ВИПАДОК РЕЦИДИВУ ТРИДЕННОЇ МАЛЯРІЇ
Authors: Nykytiuk S. O. , Boiarchuk O. R. , Horishna I. L. , Hoshchynsky P. V. , Chubata O. B. , Dyvoniak O. M. 
Published: December 2019

Метою роботи було проаналізувати клінічний випадок триденної малярії у пацієнта з вираженим абдомінальним синдромом, встановити особливості його діагностики.
Громадянин Індії був госпіталізований у хірургічне відділення Тернопільської обласної дитячої клінічної лікарні у зв’язку з гарячкою та вираженим абдомінальним синдромом. Два роки тому переніс малярію. Особливістю представленого клінічного випадку є домінування гарячки без характерної циклічності та вираженого абдомінального болю в дебюті хвороби. Спленомегалія та анемія спостерігались на другому тижні хвороби.
Необхідно підвищити настороженість лікарів щодо малярії у пацієнтів з гарячкою, які прибули з ендемічних країн.
Contributions of Geography and Nongeographic Factors to the White‐Black Gap in Hospital Quality for Coronary Heart Disease: A Decomposition Analysis
Authors: Popescu Ioana , Huckfeldt Peter , Pane Joseph D. , Escarce José J. 
Published: December 2019

Background

Differences in hospital proximity and nongeographic factors affect disparities in hospital quality for heart disease, but their relative contributions are unknown. The current study quantifies the influences of these factors on the white‐black gap in high‐ and low‐quality hospital use for acute myocardial infarction (
AMI
) and coronary artery bypass grafting (
CABG
) surgery.

Methods and Results

We used Medicare claims to identify fee‐for‐service Medicare beneficiaries aged 65 and older hospitalized during 2009–2011 with
AMI
(n=384 443) and
CABG
(n=71 411). Hospital quality was measured using publicly available
AMI
mortality rates. In national and regional analyses, we used conditional multinomial logit models to estimate the white‐black gap in high‐ and low‐quality hospital use and decompose the gap into geographic and nongeographic contributions. Overall, more whites used high‐quality hospitals for both conditions (34.8% versus 32.4% for
AMI
; 39.0% versus 29.9% for
CABG
;
P
<0.001), but after accounting for distance to hospitals, the white‐black gap was significant only for
CABG
(9.1%;
P
<0.001). The nongeographic component was significant for both conditions (3.4% for
AMI
and 7.7% for
CABG
;
P
<0.001) and accounted for nearly the entire gap for
CABG
. In contrast, hospital geographic proximity was not significant. In regional analyses, white beneficiaries had higher rates of high‐quality hospital use in the Northeast (
CABG
) and South (
AMI
and
CABG
), whereas black had higher rates of high‐quality hospital use in the Midwest (
AMI
).

Conclusions

White‐black differences in high‐quality hospital use were significant for
CABG
and related to nongeographic factors. Interventions should consider health system and contextual reasons for these disparities.
Beyond Spiritual Focus: Climate Change Awareness, Role Perception, and Action among Church Leaders in Nigeria
Authors: Nche George C. 
Published: December 2019

AbstractThis study explored the role of church leaders in addressing climate change with a focus on Catholic, Anglican, and Pentecostal churches in Nigeria. The study adopted a semistructured face-to-face interview with 30 church leaders drawn from the selected denominations (i.e., 10 church leaders from each denomination). These participants were spread across five states in five geopolitical zones in Nigeria. A descriptive narrative approach was employed in the thematic organization and analysis of data. Findings showed that while all the participants across the three denominations—Catholic, Anglican, and Pentecostal churches—agreed to have heard of climate change, their perceptions of the causes of the phenomenon were narrow and varied along religious denominational lines. More Catholic participants expressed belief in anthropogenic climate change than did Anglicans and Pentecostals. Awareness creation, charity for disaster victims, and prayer were identified by the participants as the roles churches can play in addressing climate change. Although climate change action was generally poor among participants, Catholics engaged more in organizational action than did Anglicans and Pentecostals. In contrast, climate change actions were more on a personal level than on the organizational/church level within Pentecostal churches. The implications of the findings for the Church/church leaders, policy, and future research are discussed.
Predictors for acute and chronic renal failure and survival in patients supported with veno-arterial extracorporeal membrane oxygenation
Authors: Pabst Dirk , Sanchez-Cueva Patricio A , Soleimani Behzad , Brehm Christoph E 
Published: December 2019

Background: Renal failure is a common occurrence in patients with refractory cardiogenic shock including those supported with veno-arterial extracorporeal membrane oxygenation. Prevalence and outcome of acute and chronic kidney failure in extracorporeal membrane oxygenation patients have not been well documented. In this study, we investigated the occurrence of acute and chronic kidney failure in veno-arterial extracorporeal membrane oxygenation patients as well as predictors for survival. Methods: This is a single center retrospective clinical study. We included adult patients with refractory cardiogenic shock who were supported by veno-arterial extracorporeal membrane oxygenation between 2008 and 2015. The primary endpoint of the study was acute kidney injury (KDIGO Stage 3) during extracorporeal membrane oxygenation and chronic kidney failure requiring renal replacement therapy, 30 and 90 days after extracorporeal membrane oxygenation. The secondary endpoint was in-hospital survival and 90-day survival. Results: A total of 196 veno-arterial extracorporeal membrane oxygenation patients were investigated. In total, 41.8% (82/196) patients had acute renal failure requiring continuous renal replacement therapy during extracorporeal membrane oxygenation. The 30- and 90-day survival was 55.1% (108/196) and 48.5% (95/196), respectively; 21.3% (23/108) and 11.6% (11/95) patients needed renal replacement therapy after 30 and 90 days, respectively. Predictors for KDIGO Stage 3 renal failure during extracorporeal membrane oxygenation were lactate (p = 0.026) and the number of blood units transfused during extracorporeal membrane oxygenation support (p = 0.000). A predictor for renal replacement therapy after 30 and 90 days was an elevated plasma-free hemoglobin level. The in-hospital survival was 54.6% (107/196). Serum lactate of less than 4.3 mmol/L, lower age, plasma-free hemoglobin of ⩽62 mg/dL, low number of blood units transfused during extracorporeal membrane oxygenation, and the use of an intra-aortic balloon pump were predictors for in-hospital and 90-day survival.
Short-term integrated rehabilitation for people with newly diagnosed thoracic cancer: a multi-centre randomized controlled feasibility trial
Authors: Bayly Joanne , Fettes Lucy , Douglas Eleanor , Teixiera Maria J , Peat Nicola , Tunnard India , Patel Vishit , Gao Wei , Wilcock Andrew , Higginson Irene J , Maddocks Matthew 
Published: December 2019

Objectives: The main objective of this study is to determine the feasibility of recruiting and retaining patients recently diagnosed with thoracic cancer to a trial of short-term integrated rehabilitation; evaluate uptake of theoretically informed components targeting physical function, symptom self-management and participation; estimate sample size requirements for an efficacy trial. Design: Parallel group randomized controlled feasibility trial. Setting: Three U.K. hospitals. Participants: Patients ⩽eight weeks of thoracic cancer diagnosis, Eastern Cooperative Oncology Group Performance Status 0–3, any cancer stage and treatment plan. Interventions: Participants randomly allocated (1:1) to short-term integrated rehabilitation and standard care or standard care alone over 30 days. Main measures: Primary: participant recruitment and retention, targeting ⩾30% of eligible patients enrolling and ⩾50% of participants reporting outcomes at 30 days. Secondary: intervention fidelity; missing data and performance of outcome measures for self-efficacy, symptoms, physical activity and health-related quality of life. Results: Of 159 eligible patients approached, 54 (34%) were recruited. A total of 44 (82%) and 39 (72%) participants reported outcomes at 30 and 60 days, respectively. Intervention fidelity was high. Rehabilitation was delivered across 3 (1–3) sessions over 32 (22–45) days (median (range)). Changes in clinical outcomes were modest but most apparent at 60 days for health-related quality of life: Functional Assessment of Cancer Therapy Lung Cancer score median (interquartile range) change 9.7 (−12.0 to 16.0) rehabilitation versus 2.3 (−15.0 to 14.5) standard care. Conclusion: A trial to examine efficacy of short-term integrated rehabilitation for people newly diagnosed with thoracic cancer is feasible. A sample of 336 participants could detect a meaningful effect on health-related quality of life as the primary outcome.
Correlates of fear of falling and falls efficacy in geriatric patients recovering from hip/pelvic fracture
Authors: Eckert Tobias , Kampe Karin , Kohler Michaela , Albrecht Diana , Büchele Gisela , Hauer Klaus , Schäufele Martina , Becker Clemens , Pfeiffer Klaus 
Published: December 2019

Objective: To gain a better understanding about the nature of fear of falling, this study analyzed associations between psychological and physical aspects related to fear of falling and falls efficacy in hip/pelvic fracture patients. Design: Baseline data of a randomized controlled trial. Setting: Geriatric inpatient rehabilitation hospital. Subjects: In all, 115 geriatric patients with hip/pelvic fracture (mean age: 82.5 years) reporting fear of falling within first week of inpatient rehabilitation. Interventions: None. Main measures: Falls efficacy (Short Falls Efficacy Scale–International; Perceived Ability to Manage Falls), fear of falling (one-item question), fall-related post-traumatic stress symptoms (six items based on Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV) criteria), physical performance (Short Physical Performance Battery) and psychological inflexibility (Acceptance and Action Questionnaire-II) were assessed. Results: Path analyses demonstrated that low falls efficacy (Short Falls Efficacy Scale International) was significantly related to poor physical performance ( β* = –.277, P ⩽ .001), but not to psychological inflexibility and fall-related post-traumatic stress symptoms ( P ⩾ .05.). Fear of falling was directly associated with fall-related post-traumatic stress symptoms ( β*= .270, P = .007) and indirectly with psychological inflexibility ( β*= .110, P = .022). Low perceived ability to manage falls was significantly related to previous falls ( β* = –.348, P ⩽ .001), psychological inflexibility ( β* = –.216, P = .022) and female gender ( β* = –.239, P ⩽ .01). Conclusion: Falls efficacy and fear of falling constitute distinct constructs. Falls efficacy measured with the Short Falls Efficacy Scale International reflects the appraisal of poor physical performance. Fear of falling measured by the single-item question constitutes a fall-specific psychological construct associated with psychological inflexibility and fall-related post-traumatic stress symptoms.
Marketing Response Modelling: Impact of Digital Marketing for a Luxury Car Brand
Authors: Dash Mihir , Sharma Kshitiz 
Published: December 2019

The luxury car segment is the most vibrant segment in the luxury goods market, experiencing high growth in recent years in the emerging economies of China, India, and Brazil. In India, the luxury car segment is dominated by three major players, that is, Audi, Mercedes-Benz, and BMW, together accounting for 85 per cent of the total Indian luxury car segment. The study proposes a marketing response model for luxury car brands, involving a linear model with all possible interaction effects. The model is applied in the case of a luxury car brand which had recently adopted digital marketing in addition to its traditional advertising media mix. The response in the form of customer queries at its showroom (situated in Bangalore, India) was taken as the dependent variable. The independent variables were the advertising expenditure in different media, viz. newspapers and magazines, display events, and digital media. The results of the model provide a measure of the effectiveness of each of the media, the interaction between them, as well as the impact of digital marketing.
Health$en$eTM: Developing a Board Game on Value-based Healthcare Financing
Authors: Tan Harold , Wei Yap Chun , Yun Heng Wei , Joan Koh Eng Hui , Yee Ho Wai , Juan Lim Yee 
Published: December 2019

Background. With rising healthcare costs, there is a need to transform healthcare financing to provide better care value and sustainability. Healthcare providers and consumers need to be educated about value-based care and financing. This can be done through games. Intervention & Methods. We describe the design of our board game Health$en$eTM which aims to let players simulate the role of funding patients’ care as the patients move across the care value chain. In the game, players will learn how certain care funding innovations help to optimize healthcare expenditure for better value. Discussion & Conclusion. We envisage that some game elements of Health$en$eTM may motivate players to transform healthcare financing systems in the real world. We formulate a matrix to predict the possible associations between game elements and psychological core drives relevant to Health$en$eTM. Further analysis of the game’s potential impact and validation of the matrix could be conducted in due course after the game is launched in a workshop.
CNVScope: Visually Exploring Copy Number Aberrations in Cancer Genomes
Authors: Dalgleish James LT , Wang Yonghong , Zhu Jack , Meltzer Paul S 
Published: December 2019

Motivation: DNA copy number (CN) data are a fast-growing source of information used in basic and translational cancer research. Most CN segmentation data are presented without regard to the relationship between chromosomal regions. We offer both a toolkit to help scientists without programming experience visually explore the CN interactome and a package that constructs CN interactomes from publicly available data sets. Results: The CNVScope visualization, based on a publicly available neuroblastoma CN data set, clearly displays a distinct CN interaction in the region of the MYCN, a canonical frequent amplicon target in this cancer. Exploration of the data rapidly identified cis and trans events, including a strong anticorrelation between 11q loss and17q gain with the region of 11q loss bounded by the cell cycle regulator CCND1. Availability: The shiny application is readily available for use at http://cnvscope.nci.nih.gov/ , and the package can be downloaded from CRAN ( https://cran.r-project.org/package=CNVScope ), where help pages and vignettes are located. A newer version is available on the GitHub site ( https://github.com/jamesdalg/CNVScope/ ), which features an animated tutorial. The CNVScope package can be locally installed using instructions on the GitHub site for Windows and Macintosh systems. This CN analysis package also runs on a linux high-performance computing cluster, with options for multinode and multiprocessor analysis of CN variant data. The shiny application can be started using a single command (which will automatically install the public data package).
VMAT Optimization and Dose Calculation in the Presence of Metallic Hip Prostheses
Authors: Parenica Holly M. , Mavroidis Panayiotis , Jones William , Swanson Gregory , Papanikolaou Niko , Stathakis Sotirios 
Published: December 2019

Introduction: This research quantifies and compares the effect of hip prostheses on dose distributions calculated using collapsed cone convolution superposition and Monte Carlo (with and without correcting for the density of the implant and surrounding tissues). The use of full volumetric modulated arc therapy arcs versus volumetric modulated arc therapy arcs avoiding the hip implants (skip arcs) was also studied. Materials and Methods: Six prostate patients with hip prostheses were included in this study. The hip prostheses and the streaking artifacts on the computed tomography images were contoured by a single physician, and full volumetric modulated arc therapy arcs were created in the Pinnacle3 TPS. Copies of each plan were made, and the doses were recalculated with the densities of the prostheses and surrounding tissues overridden. The plans were then exported to Monaco and recalculated using a Monte Carlo dose calculation algorithm, with and without densities of the prosthesis and surrounding tissues overridden. Results: With density overrides, Pinnacle3 had a 4.4% error for ion chamber measurements. Monaco was within 0.2% of ion chamber measurement when density overrides were used. On average, when density overrides were used in Pinnacle3 for patient dose calculations, the planning target volume D95 value dropped from 99.3% to 82.7%. Monaco also showed decreased planning target volume coverage when plans were recalculated with correct density information. Full arc plans (with density overrides) for the patient with a bilateral prosthesis provided significant bladder sparing and some rectal sparing compared to skip arc plans. Conclusion: When planning for prostate patients with hip prostheses, correct density information for implants and surrounding tissues should be used to optimize the plan and ensure optimal accuracy. If available, a Monte Carlo algorithm should be used as a second check. Full arcs could be used to spare dose to organs at risk, while maintaining adequate planning target volume coverage, when using a Monte Carlo dose calculation algorithm.
MiR-142-5p Acts as a Significant Regulator Through Promoting Proliferation, Invasion, and Migration in Breast Cancer Modulated by Targeting SORBS1
Authors: Yu Weixuan , Li Dongwei , Zhang Yunda , Li Cheukfai , Zhang Chuanzhao , Wang Libin 
Published: December 2019

Background: Numerous researches have demonstrated that miR-142-5p plays significant roles in several cancers, although the functional characteristic of miR-142-5p in breast cancer has not been determined. This study is designed to explore the biological significance of miR-142-5p in breast cancer clinical implication and mechanism of action. Methods: The differential expression patterns of miR-142-5p and Sorbin and SH3 domain-containing protein 1 and correlations between them and clinical significances were analyzed based on data from database. The expression levels of miR-142-5p in breast cancer cells were detected using quantitative real-time polymerase chain reaction. Cell counting kit-8, transwell, and wound healing assays were used to explore the potential functions of miR-142-5p in breast cancer cells. In addition, bioinformatics prediction analysis and luciferase reporter assay were utilized to predict and identify the potential target gene of miR-142-5p. A rescue experiment was conducted by transfecting miR-142-5p inhibitors and si-Sorbin and SH3 domain-containing protein 1 into cells to explore miR-142-5p/Sorbin and SH3 domain-containing protein 1 pairs on breast cancer cells behaviors. Results: The analysis results showed that miR-142-5p was highly expressed in patients with breast cancer, while Sorbin and SH3 domain-containing protein 1 presented a trend of low expression. The clinical significances analysis suggested that the overexpression of miR-142-5p is closely correlated with metastasis, while low expression of Sorbin and SH3 domain-containing protein 1 is correlated with clinicopathological characteristics and poor overall survival in patients with breast cancer. In vitro exploration, the expression of miR-142-5p was upregulated in breast cancer cells and inhibition of miR-142-5p expression significantly reduced the proliferation, invasion, and migration of breast cancer cells. Through rescue experiments, breast cancer cells proliferation, invasion, and migration reduction induced by silencing of miR-142-5p were reversed via knockdown Sorbin and SH3 domain-containing protein 1. Conclusion: Our findings insinuate that miR-142-5p functions as a positive regulator of promoting breast cancer cells biological behaviors and clinical metastasis, possibly regulated by targeting Sorbin and SH3 domain-containing protein 1, thus providing valuable information in the development of preventive or even therapeutic strategies for utilizing miR-142-5p as a promising target.
Polymorphisms of a novel long non-coding RNA RP11-108K3.2 with colorectal cancer susceptibility and their effects on its expression
Authors: Jiang Danjie , Jin Mingjuan , Ye Ding , Li Yingjun , Jing Fangyuan , Zhang Xiaocong , Li Qilong , Chen Kun 
Published: December 2019

Background: RP11-108K3.2 was recently identified as a novel long non-coding RNA (lncRNA) transcript, and several single nucleotide polymorphisms (SNPs) have been identified in its coding region. This study aimed to explore the associations of tagSNPs in RP11-108K3.2 with the risk of colorectal cancer and their effects on its expression. Methods: A total of 821 colorectal cancer cases and 857 healthy controls were enrolled into this two-stage case-control study. Demographic characteristics and lifestyle information were collected by a validated questionnaire. Six tagSNPs were genotyped by using Sequenom MassARRAY platform. A total of 71 additional colorectal cancer cases were recruited, of which the genotypes of potential polymorphisms and the RP11-108K3.2 expression levels were determined. Results: In the discovery set, only the rs2470151 C/T polymorphism was found to have a promising association with the risk of colorectal cancer, and this polymorphism was further replicated in the validation set with a significantly decreased risk of colorectal cancer (adjusted odds ratio 0.73; 95% confidence interval 0.55, 0.97). Combined discovery set and validation set together, this negative association was found both in the heterozygote codominant model and the dominant model. Furthermore, colorectal cancer patients carrying rs2470151 CT/TT genotypes had a marginally lower RNA expression of RP11-108K3.2 than those carrying the CC genotype. Stratified analyses showed the association between rs2470151 and the risk of colorectal cancer were influenced by family history of cancer, smoking, alcohol consumption, and tea drinking. Conclusions: These findings suggest that RP11-108K3.2 rs2470151 had a significant association with the risk of colorectal cancer; this may help to predict the susceptibility of colorectal cancer in Chinese populations.