bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Ketuban Pecah dengan Kejadian Asfiksia Neonatorum di RSUD Kabupaten Kediri Tahun 2016
Authors: Lestariningsih Yanu Yufita 
Published: November 2019

Premature rupture of membranerevolves 5-10% from all birth. Impact a birth premature that espoused broken fetal membrane early causess 12-15% asphyxia neonatorum. The purpose of the study to determine the correlation between premature rupture of membrane with the incidence of asphyxia neonatorum. The research method used is analytic with retrospective cohort approach with independent variable of premature rupture of membrane, dependent variable asphyxia neonatorum. The study was conducted on 7 June to 12 July 2017. The population of 1519 mothers inregional public hospital of Kediri regency 2016. Sample 139 respondents, taken by simple random sampling, was analyzed by Chi Square test with a significant of 0.05. Result of research most of respondent with rupture of membrane counted 46 respondents, almost all respondents that is 82.6% gave birth baby with asphyxia. From result of Chi Square test obtained by result of p-value equal to 0.000 (<0.05), result of coefficient of contingency (C) equal to 0.639 with closeness strong relation, so H1 received H0 rejected which means there is significant relation with closeness strong between premature rupture of membrane with asphyxia neonatorum inregional public hospital of Kediri regency 2016. Relative Risk (RR) 1.65 which means the possibility of a baby experiencing asphyxia neonatorum of 1.65 times in maternal who experience premature rupture of membranes compared to mothers who did not experience premature rupture of membranes.
Hubungan Pengetahuan Ibu Hamil tentang HIV dengan Minat Untuk Periksa HIV (PMTCT)
Authors: Wardhani Ratih Kusuma , Dinastiti Vide Bahtera , Azizah Eva Nur 
Published: November 2019

This is due to the discovery of potent and safe vaccines against HIV infection and AIDS. The purpose of this study to determine the relationship of knowledge about HIV pregnant women with an interest to check HIV (PMTCT) in Health Center Gurah Kediri district. The research design used was cross sectional. The research site was conducted at Gurah Community Health Center, Gurah District, Kediri Regency and conducted in May - June 2017. The research samples were 30 respondents. It used Purposive sampling. The independent variable in this study is the knowledge of pregnant women about HIV. The dependent variable in this study is the interest of pregnant women to check for HIV. The instrument in this study used a questionnaire. The data analysys method was Spearman Rank by using SPSS. Knowledge of pregnant women about HIV most 17 respondents (56.7%) and a fraction less 5 respondents (16.7%) enough. Interest of the respondent to check HIV (PMTCT) do not interest most of 13 respondents (43.3%) and a small 8 respondents (26.7%) less interest. There is a relationship between knowledge of HIV pregnant women with an interest to check HIV (PMTCT) with Spearman Rank analysis value is 0.645 with a positive figure shows a strong relationship level. Knowledge greatly affect the interest in performing HIV (PMTCT). Pregnant women are expected to increase the knowledge by attending counseling given by health workers, especially tentag HIV so that it will increase the interest to check HIV (PMTCT).
Characteristics, Controlling Factors, and Formation of Shallow Buried Karst in Eastern China: A Case Study in the Wuxi Metro Areas, Jiangsu Province
Authors: Guo Shulan , Yan Changhong , Yu Liangchen , Liu Yang , Zhou Yinkang , Shi Xiaozhong 
Published: November 2019

ABSTRACT
Karst-related geo-disasters often occur in karst regions during underground construction. In recent years, a number of shallow buried karst features have been discovered in eastern China. Survey boreholes show that karst caves exist at depths of 26–30 m and 33–36 m, which are typical of shallow buried karst. Using cross-hole seismic computed tomographic techniques, 36 geological anomalies consisting of 26 mud-filled caves, three empty caves, and seven fissure zones/loose lens bodies were detected. Most of the karst caves were oblate or oval. After determining the scale of and the connection between the caves, the study area was divided into two areas to provide advice on the treatment of caves during construction. An analysis of the development characteristics of the karst suggests that karst is controlled by several key factors, including topography, structural features, groundwater conditions, and human activities. Following an analysis of these factors and field studies of the process of formation of the shallow buried caves, solutions are proposed to prevent karst-related geo-hazards. The research results can be used in the design of foundations for buildings that are located in regions that include shallow buried karst in eastern China.
Technology Focus: Water Management (December 2019)
Authors: Swartwout Rosa 
Published: November 2019

Technology Focus
Recent trends in water management have taken a more-comprehensive and holistic approach toward the stewardship of water as a critical resource. The industry has broadened its view to address the complete life cycle of water, from the effect of water use, to the reuse or recycling of water, to the final disposal of•water.
In unconventional reservoirs, the use of fresh water for fracturing fluids has been reduced greatly by the development of chemistries that facilitate the use of nonfreshwater sources and flowback fluids. In recent years, the participation of midstream water companies has changed the dynamics of water management, improving the processes by which water is conveyed and increasing the use of flowback or produced water. These companies are playing an increasing role in the infrastructure and operation of water management, sometimes owning and operating water pipelines and water-storage, produced-water-treatment, and produced-water disposal facilities.•
Operators such as Southwestern Energy are taking a progressive approach in an effort to become freshwater-neutral, as outlined in paper SPE 187123.• This company, as an example, defines “freshwater-neutral” as a status in which the total water used is less than the sum of the alternative water and offsets. This company is using a combination of water-treatment technologies, aggressive water-reuse strategies, and conservation projects in local communities to achieve this goal.
Technological advances have enabled a better understanding of the potential environmental impact of final disposal of produced water. This understanding derives from improved modeling and a deeper understanding of the relationship between water-disposal techniques and the environment, including the potential effect of injection wells on induced seismicity. Similarly, operators on the Norwegian Continental Shelf are using an environmental impact factor (EIF) to identify potential risks from specific produced-water discharges. The goal is to achieve an EIF known as “zero effects release.” The EIF can also be used to quantify the beneficial effects of different water-treatment methods.
Recommended additional reading at OnePetro: www.onepetro.org.
SPE 194575 A Case Study on Treating•Oil Contaminants and Heavy•Metal of Produced Water Through•Phytoremediation Using Reed-Bed Technology: A Success Story•of•15 Years of Operation of Heglig•Oil•Field•of Sudan by•Ajay Kumar, GNPOC Sudan, et al.
SPE 191529 Fit-for-Purpose Water Treatment in Permian Shale—Field Data,•Laboratory Data, and Comprehensive•Overview by John Walsh,•CETCO Energy Services, et al.
OMC 2019 1101 Analysis and Comparison•of Different Solutions for•Produced-Water Management—LCA•and Biodiversity Impact Assessment•by•Martino Pedullà, RINA•Consulting, et al.
Forced Treadmill Running Reduces Systemic Inflammation Yet Worsens Upper Limb Discomfort in a rat model of Work-Related Musculoskeletal Disorders
Authors: Smith Tianqi Tenchi Gao , Barr-Gillespie Ann E , Klyne David M , Harris Michelle Y , Amin Mamta , Paul Ryan W , Cruz Geneva E , Gallagher Sean , Zhao Huaqing , Barbe Mary Frances 
Published: November 2019

Abstract
Background: Musculoskeletal disorders can result from prolonged repetitive and/or forceful movements. Performance of an upper extremity high repetition high force task increases serum pro-inflammatory cytokines and upper extremity sensorimotor declines in a rat model of work-related musculoskeletal disorders. Since one of the most efficacious treatments for musculoskeletal pain is exercise, this study investigated the effectiveness of treadmill running in preventing these responses.
Methods: Twenty-nine young adult female Sprague-Dawley rats were used. Nineteen were trained for 5 weeks to pull a lever bar at high force (15 min/day). Thirteen went on to perform a high repetition high force reaching and lever-pulling task for 10 weeks (10-wk HRHF; 2 hrs/day, 3 days/wk). From this group, five were randomly selected to undergo forced treadmill running exercise (TM) during the last 6 weeks of task performance (10-wk HRHF+TM, 1 hr/day, 5 days/wk). Results were compared to 10 control rats and 6 rats that underwent 6 weeks of treadmill running following training only (TR-then-TM). Voluntary task and reflexive sensorimotor behavioral outcomes were assessed. Serum was assayed for inflammatory cytokines and corticosterone, reach limb median nerves for CD68+ macrophages and extraneural thickening, and reach limb flexor digitorum muscles and tendons for pathological changes.
Results: 10-wk HRHF rats had higher serum levels of IL-1α, IL-1β and TNFα, than control rats. In the 10-wk HRHF+TM group, IL-1β and TNFα were lower, whereas IL-10 and corticosterone were higher, compared to 10-wk HRHF only rats. Unexpectedly, several voluntary task performance outcomes (grasp force, reach success, and participation) worsened in rats that underwent treadmill running, compared to untreated 10-wk HRHF rats. Examination of forelimb tissues revealed lower cellularity within the flexor digitorum epitendon but higher numbers of CD68+ macrophages within and extraneural fibrosis around median nerves in 10-wk HRHF+TM than 10-wk HRHF rats.
Conclusions: Treadmill running was associated with lower systemic inflammation and moderate tendinosis, yet higher median nerve inflammation/fibrosis and worse task performance and sensorimotor behaviors. Continued loading of the injured tissues in addition to stress-related factors associated with forced running/exercise likely contributed to our findings.
Dementia assessment and diagnostic practices of healthcare workers in rural southwestern Uganda: a cross-sectional qualitative study
Authors: Kamoga Ronald , Rukundo Godfrey Z. , Wakida Edith K. , Nakidde Gladys , Obua Celestino , Buss Stephanie S. 
Published: November 2019

Abstract
Background:
An estimated 50 million people worldwide have Alzheimer’s disease and related dementias (ADRD), and this number is projected to increase with the growth of the aging population, with the largest growth occurring in low and middle income countrie . Diagnostic coverage for dementia is estimated to be only 5-10% in low- and middle-income countries. Timely diagnosis of ADRD could prompt early access to information, medical treatments, and support for caregivers. The aim of this study was to assess how healthcare workers in rural southwestern Uganda assess for and diagnose ADRD.
Methods:
We used in-depth interviews to investigate the medical knowledge and clinical practices surrounding ADRD diagnoses among 42 healthcare workers employed at mid-tier health facilities in southwestern Uganda. Qualitative content analysis was used to identify distinct categories and themes.
Results:
Our findings show that healthcare workers without specific mental health training assessed and diagnosed dementia based on history and physical examination alone. On the other hand, healthcare workers with some specialized training in mental health were more likely to use neuropsychological tests, blood tests, urine tests, and brain imaging in the diagnosis of dementia. Collateral history from caregivers was noted to be very important in proper assessment and diagnosis of dementia among all categories of healthcare workers. The majority of healthcare workers regarded memory loss as part of the normal aging process and reported that it does not need any specific treatment. Other healthcare workers could recognize signs and symptoms of dementia, but focused on managing other medical problems at the expense of assessing cognitive decline and mental health. Diagnostic practices did not differ based on age, years of experience, or gender of the healthcare workers.
Conclusion:
These results indicate that specialized training in mental health among healthcare workers is crucial for the assessment and diagnosis of ADRD in rural southwestern Uganda.
Linc01234 promotes cell proliferation and metastasis in oral squamous cell carcinoma via miR-433/PAK4 axis
Authors: LIU Deyu , jian xinchun , XU PU , ZHU Rong , WANG Yuan 
Published: November 2019

Abstract
Background: Mounting studies demonstrate long non-coding RNA s ( lncRNAs ) play an important role in tumor progression. However, the potential biological functions and clinical importance of Linc01234 in oral squamous cell carcinoma ( OSCC ) still remain unclear.
Methods: We evaluated the expression profile and prognostic values of Linc01234 in OSCC tissues via RT-qPCR. Then, functional experiments in vitro were performed to investigate the effects of Linc01234 on tumor growth, migration and invasion in OSCC. Mechanistically, RT-qPCR, bioinformatic analysis and dual luciferase reporter assays were performed to identify a competitive endogenous RNA s ( ceRNA s) among Linc01234, miR-433-3p and PAK4.
Results: We found that Linc01234 was evidently upregulated in OSCC tissues and cell lines, and its level was positively associated with T stage, lymphnode metastasis, differentiation and poor prognosis of patients with OSCC. Our results found that Linc01234 inhibited cell proliferation and metastasis abilities in CAL27 and SCC25 cells following its deletion. Mechanistic analysis indicated that Linc01234 may act as a ceRNA (competing endogenous RNA) of miR-433-3p to relieve the repressive effect of miR-433-3p on its target PAK4.
Conclusions: Our results indicated that Linc01234 promotes OSCC progression through Linc01234/miR-433/PAK4 axis and might be a potential therapeutic target for OSCC.
Icotinib is as efficacious as gefitinib for brain metastasis of EGFR mutated non-small-cell lung cancer
Authors: Liu Kejun , Jiang Guanming , Zhang Ailing , Li Zhuanghua , Jia Jun 
Published: November 2019

Abstract
Background: The prognosis of non-small-cell lung cancer (NSCLC) with brain metastases is very poor. Currently, therapeutic methods for this patient population include whole-brain radiation therapy (WBRT), surgery, radiosurgery and systemic treatment. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) could be effective on cerebral metastases of mutated NSCLC. However, which EGFR-TKIs is more appropriate is still unknown.
Methods: A total of 43 patients were recruit in this study. Among them, 21 cases received icotinib (125 mg, thrice a day) and 22 received cases geﬁtinib (250 mg, once a day) until disease progression or unacceptable toxicity. The primary end point of this study was intracranial PFS (iPFS). The relationships between therapeutic arms and patients characteristics were performed using Pearson’s chi-square test or Fisher’s exact test. The differences in PFS among the two arms were analyzed using Kaplan-Meier curves and log rank tests.
Results: There was no significant difference of intracranial ORR (66.6% versus 59.1%, P =0.62) and DCR (85.7% versus 81.8%, P =0.73) between the two arms. The median intracranial PFS (iPFS) for icotinib and gefitinib arms were 8.4 months (95% CI, 5.4 to 11.3 months) and 10.6 months (95% CI, 6.3 to 14.8 months), respectively (P =0.17). Adverse events of the two study arms were generally mild. None of the patients experienced dose reduction of EGFR-TKIs.
Conclusions: Our study showed that icotinib and geﬁtinib had similar efficacy for brain metastasis of EGFR mutated NSCLC. Large randomized studies are suggested to further illuminate the effect of these two EGFR-TKIs on cerebral lesions of NSCLC.
Incidence, clinical implications and impact on public health of infections with Shigella spp. and entero-invasive Escherichia coli (EIEC): results of a multicenter cross-sectional study in the Netherlands during 2016-2017
Authors: Beld Maaike van den , Warmelink Esther , Friedrich Alexander W. , Reubsaet Frans A.G. , Schipper Maarten , de Boer Richard F. , Notermans Daan W. , Petrignani Mariska W. F. , Zanten Evert van , Rossen John W.A. , Friesema Ingrid H.M. , Kooistra A.M.D. (Mirjam) 
Published: November 2019

Abstract
Background: Shigella spp. and entero-invasive E. coli (EIEC) use the same invasive mechanism to cause diarrheal diseases. Public health regulations apply only to Shigella spp. infections, but are hampered by the lack of simple methods to distinguish them from EIEC. In the last decades, molecular methods for detecting Shigella spp. and EIEC were implemented in medical microbiological laboratories (MMLs). However, shigellosis cases identified with molecular techniques alone are not notifiable in most countries. Our study investigates the impact of EIEC versus Shigella spp. infections and molecular diagnosed shigellosis versus culture confirmed shigellosis for re-examination of the rationale for the current public health regulations.

Methods: In this multicenter cross-sectional study, fecal samples of patients suspected for gastro-enteritis, referred to fifteen MMLs in the Netherlands, were screened by PCR for Shigella spp. or EIEC. Samples were cultured to discriminate between the two pathogens. We compared risk factors, symptoms, severity of disease, secondary infections and socio-economic consequences for (i) culture-confirmed Shigella spp. versus culture-confirmed EIEC cases (ii) culture positive versus PCR positive only shigellosis cases.

Results: In 2016-2017, 777 PCR positive fecal samples with patient data were included, 254 of these were culture-confirmed shigellosis cases and 32 were culture-confirmed EIEC cases. EIEC cases were more likely to report ingestion of contaminated food and were less likely to be men who have sex with men (MSM). Both pathogens were shown to cause serious disease although differences in specific symptoms were observed. Culture-negative but PCR positive cases were more likely report travel or ingestion of contaminated food and were less likely to be MSM than culture-positive cases. Culture-negative cases were more likely to suffer from multiple symptoms. No differences in degree of secondary infections were observed between Shigella spp. and EIEC, and culture-negative and culture-positive cases.

Conclusions: No convincing evidence was found to support the current guidelines that employs different measures based on species or detection method. Therefore, culture and molecular detection methods for Shigella spp. and EIEC should be considered equivalent for case definition and public health regulations regarding shigellosis. Differences were found regarding risks factors, indicating that different prevention strategies may be required.
Co-infection of Anaplasma and Ehrlichia in Hedgehogs from China.
Authors: Xiao Xiao , Han Hui-Ju , Qi Rui , Gong Xiao-Qing , Lei Si-Cong , Liu Jian-Wei , Qin Xiang-Rong , Zhou Chuan-Min , Fang Li-Zhu , Ma Xiao-Juan , Chu Min , Yu Xue-Jie 
Published: November 2019

Abstract
Hedgehogs ( Erinaceus amurensis ) is an insectivorous mammal frequently observed in the wild and around the residential areas. However, information about tick-borne diseases in this species is not well known. We investigated tick-borne rickettsial pathogens including Anaplasma , Ehrlichia, Candidatus . Neoehrlichia and Rickettsia in hedgehogs collected in central China. Hedgehogs were captured from Hubei and Jiangxi Province with living traps. PCR amplification and DNA sequencing showed that 26% (19/73) hedgehogs were positive to Anaplasma bovis, 20.5% (15/73) were positive to a tentative new Ehrlichia species; in addition, 13.7% (10/73) hedgehogs were positive to A. bovis and Ehrlichia simultaneously. Ca . Neoehrlichia and Rickettsia species was not detected among the 73 hedgehogs. We concluded that hedgehogs from central China were widely infected with Anaplasma and Ehrlichia , suggesting hedgehogs may play a role in the ecology of Anaplasma and Ehrlichia .
A comparative gene co-expression networks analysis of two congener filmy ferns identifies specific desiccation tolerance mechanisms associated to their microhabitat preference.
Authors: Ostria-Gallardo Enrique , Larama Giovanni , Berríos Graciela , Fallard Ana , Gutierrez Ana , Ensminger Ingo , Bravo León A. 
Published: November 2019

Abstract
Background Filmy-ferns (Hymenophyllaceae) are poikilohydric, homoiochlorophyllous desiccation-tolerant (DT) epiphytes. They can colonize lower and upper canopy environments of humid forest. Filmy-ferns desiccate rapidly (hours), contrasting with DT angiosperms (days/weeks). We hypothesized that desiccation tolerance in filmy-ferns would be associated mainly with constitutive features rather than induced responses during dehydration. Hence, the inter-specific differences in vertical distribution would be associated with different dynamics of gene expression within the dehydration or rehydration phases. A comparative transcriptomic analysis with an artificial neural network was done on Hymenophyllum caudiculatum (restricted to lower canopy) and Hymenophyllum dentatum (reach upper canopy) during a desiccation/rehydration cycle.Results Raw reads were assembled into 69,599 transcripts for H. dentatum and 34,726 transcripts for H. caudiculatum . Few transcripts showed significant changes in differential expression (DE). H. caudiculatum had ca. twice DE genes than H. dentatum and higher proportion of increased-and-decreased abundance of genes occurs during dehydration. In contrast, the abundance of genes in H. dentatum decreased significantly when transitioning from dehydration to rehydration. According to the artificial neural network results, H. caudiculatum enhanced osmotic responses and phenylpropanoid related pathways, whilst H. dentatum enhanced its immune system responses and protection against high light stress.Conclusions Our findings provide a deeper understanding of the mechanisms underlying the desiccation tolerance responses of two filmy ferns and the relationship between the species-specific response and the microhabitats these ferns occupy in nature.