bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pronunciation Can Be Acquired Outside the Classroom: Design and Assessment of Homework‐Based Training
Authors: MARTIN INES A. 
Published: May 2020

AbstractEven though there is ample evidence that pronunciation plays a crucial role in effective second language (L2) communication, pronunciation training is frequently neglected in L2 classrooms due to time constraints or because instructors do not feel adequately prepared to teach pronunciation. To address this discrepancy, the present study investigates the effectiveness of a novel, homework‐based method of pronunciation instruction. Novice German learners’ (N = 122) perception and oral production skills on the word and sentence level were assessed at the beginning and the end of the semester. Learners were assigned to 1 of 3 groups: a homework‐based pronunciation training group, an in‐class training group, and a control group. The results showed that the learners in the homework training group significantly outperformed learners in the control group on some (but not all) measures of phonological perception skills and on comprehensibility measures of productions of individual words. Results further revealed no significant difference between learners who received homework‐based or in‐class pronunciation training and responses on a debriefing questionnaire showed that learners were equally satisfied with both training modalities. Taken together, these results suggest that homework‐based pronunciation training is similarly effective as in‐class practice.
Expanding criteria for slow colonic transit in patients being evaluated for chronic constipation by scintigraphy
Authors: Khoshbin Katayoun , Busciglio Irene , Burton Duane , Breen‐Lyles Margaret K. , Camilleri Michael 
Published: May 2020

AbstractBackgroundColonic transit measurement [geometric center (GC) at 24 and 48 hours] identifies slow transit constipation (STC) in patients with chronic constipation.AimTo evaluate the utility of the difference between GC24 and GC48 (Δ48‐24) to identify STC in adults with chronic constipation.MethodsWe reviewed medical records of 250 patients, aged 18‐75 years, who underwent colonic transit by scintigraphy during 1994‐2019 for investigation of chronic constipation. Data collected included demographics, medical and surgical histories, and anorectal manometry. We used colonic transit from 220 healthy controls to identify the 5th percentile for diagnosing STC: 1.3 at 24 hours, and 1.9 at 48 hours. In addition, the 5th percentile for Δ48‐24 was 0.38 for females and 0.29 for males. Data are reported as median and IQR [Q1, Q3]).Key resultsAmong the 250 patients [median age 42.5 years (IQR 30.75, 56), 84% female], based on GC24 < 1.3, 52 (20.8%) had STC (3 males, 49 females); and based on GC48 < 1.9, 28(11.2%) had STC (3 males, 25 females). Colonic transit was normal in 74.8%. In the groups with normal GC24 and GC48, Δ48‐24 identified an additional 32(15.1%) of 212 female patients and 4 (10.5%) of 38 male patients with slow progression of colonic transit between 24 and 48 hours. Among these 36 patients with abnormal Δ48‐24, 13(36.1%) had evidence of rectal evacuation disorder.Conclusions & InferencesΔ48‐24 measurement on scintigraphic colonic transit can identify an additional 9.2% of STC in patients with constipation without rectal evacuation disorder and can help individualize treatment of chronic constipation.
Designer drugs: a medicinal chemistry perspective (II)
Authors: Carroll F. Ivy , Lewin Anita H. , Mascarella S. Wayne , Seltzman Herbert H. , Reddy P. Anantha 
Published: May 2020

AbstractDuring 2012–2018, the clandestine manufacture of new psychoactive substances (NPS) designed to circumvent substance control regulations increased exponentially worldwide, with concomitant increase in fatalities. This review focuses on three compound classes identified as synthetic opioids, synthetic amphetamines, and synthetic cannabinoids and highlights the medicinal chemistry precedents utilized by clandestine laboratories to develop new NPS with increased brain penetration, longer duration of action, and greater potency. Chemical approaches to illicit drug abuse treatment options, particularly for opioid use disorder, are also discussed.
The SARS‐CoV‐2/COVID‐19 pandemic and challenges in stroke care in India
Authors: Sylaja P. N. , Srivastava M. V. Padma , Shah Sudhir , Bhatia Rohit , Khurana Dheeraj , Sharma Arvind , Pandian Jeyaraj D. , Kalia Kiran , Sarmah Deepaneeta , Nair Sruthi S. , Yavagal Dileep R. , Bhattacharya Pallab 
Published: May 2020

AbstractStroke care in India has evolved rapidly in the last decade with a focus on stroke awareness, prevention, rapid triage, treatment, and rehabilitation. But acute stroke care and poststroke rehabilitation in the country have limitations owing to the economic constraints and poor access to health care. The SARS‐CoV‐2/COVID‐19 pandemic has made stroke care even more challenging. We outline the unfavorable circumstances in stroke care induced by the pandemic; propose mitigating measures; crisis management; and provide a comparative evaluation of stroke care between India and the United States during the pandemic. There is a need for public health systems in both developed and developing countries to improve awareness, implement proper strategies of triage, acute treatment, well‐defined rehabilitation plans, telemedicine services, and virtual check‐ins.
Leadless pacemaker use in a patient with a durable left ventricular assist device
Authors: Parker Alex M. , Vilaro Juan R. , Aranda Juan M. , Al‐Ani Mohammad , George Phillip , Ahmed Mustafa M. 
Published: May 2020

AbstractThere is limited known safety and efficacy of leadless pacemaker device use in patients with durable left ventricular assist devices (LVADs). We present a case of a pacemaker‐dependent LVAD patient with infection of permanent transvenous pacemaker who underwent successful implantation of Micra transcatheter pacing system (Medtronic).
Preventing food allergy in infancy and childhood: Systematic review of randomised controlled trials
Authors: de Silva Debra , Halken Susanne , Singh Chris , Muraro Antonella , Angier Elizabeth , Arasi Stefania , Arshad Hasan , Beyer Kirsten , Boyle Robert , du Toit George , Eigenmann Philippe , Grimshaw Kate , Hoest Arne , Jones Carla , Khaleva Ekaterina , Lack Gideon , Szajewska Hania , Venter Carina , Verhasselt Valérie , Roberts Graham ,   European Academy of Allergy, Clinical Immunology Food Allergy, Anaphylaxis Guidelines Group
Published: May 2020

AbstractBackgroundThis systematic review of ways to prevent immediate‐onset/IgE‐mediated food allergy will inform guidelines by the European Academy of Allergy and Immunology (EAACI).MethodsThe GRADE approach was used. Eleven databases were searched from 1946 to October 2019 for randomized controlled trials (and large prospective cohort studies in the case of breastfeeding). The studies included heterogeneous interventions, populations, and outcomes and so were summarized narratively.ResultsForty‐six studies examined interventions to reduce the risk of food allergy in infancy (up to 1 year) or early childhood. The following interventions for pregnant or breastfeeding women and/or infants may have little to no effect on preventing food allergy, but the evidence is very uncertain: dietary avoidance of food allergens, vitamin supplements, fish oil, probiotics, prebiotics, synbiotics, and emollients. Breastfeeding, hydrolyzed formulas, and avoiding cow's milk formula may not reduce the risk of cow's milk protein allergy; however, temporary supplementation with cow's milk formula in the first week of life may increase the risk of cow's milk allergy. Introducing well‐cooked egg, but not pasteurized raw egg, from 4 to 6 months probably reduces the risk of hen’s egg allergy. Introducing regular peanut consumption into the diet of an infant at increased risk beginning from 4 to 11 months probably results in a large reduction in peanut allergy in countries with a high prevalence. These conclusions about introducing peanut are based on moderate certainty evidence, from single trials in high‐income countries.ConclusionsSixty percent of the included studies were published in the last 10 years, but much still remains to be understood about preventing food allergy. In particular, there is a need to validate the potential benefits of early introduction of food allergens in a wider range of populations.
The effectiveness of cognitive analytic therapy for borderline personality disorder: Utilizing a withdrawal experimental design to improve sensitivity to abandonment
Authors: Kellett Stephen , Gausden Joe , Gaskell Chris 
Published: May 2020

ObjectivesA primary methodological weakness of the single‐case experimental design (SCED) outcome studies conducted of the treatment of personality disorder with cognitive analytic therapy (CAT) is that they have failed to employ a withdrawal phase or cross‐over design and so are deemed quasi‐experimental. This study sought to implement a withdrawal design, in order to improve the internal validity of the study to make it a true SCED, and also in order to enable the patient to explore abandonment dynamics.DesignThe study employed an A1/B1/A2/B2 with extended follow‐up SCED with a female patient treated with CAT meeting diagnostic criteria for borderline personality disorder (BPD). Following the 6‐week baseline period ‘A1’, treatment occurred in two phases (21 sessions ‘B1’ and 24 sessions ‘B2’) sandwiching a 12‐week treatment withdrawal phase (‘A2’) and a 24‐week structured follow‐up phase. Seven idiographic daily measures were collected that created a N = 698 day timeline. Nomothetic outcome measures were collected at baseline and at the end of each phase of the study, and the Session Impact Scale was completed after each treatment session.ResultsThere was a significant increase in the task focus of treatment sessions. Ideographically, CAT was an effective treatment for improving the participant’s self‐to‐self relationship, as their self‐hate reduced and their sense‐of‐self increased. There was a broad pattern of deterioration during the second treatment phase (B2) and follow‐up phase across the ideographic measures, and CAT was ineffective for BPD ideographic emotional or self‐to‐other measures. Reliable change occurred on the primary BPD nomothetic outcome measure from baseline to end of first treatment phase.ConclusionsThe study suggests that the CAT intervention was partially successful and that it is possible to integrate good research practice with clinical innovation. The methodological strengths and limitations of the design and the clinical implications of the results are discussed.Practitioner points

Cognitive analytic therapy was partially effective in the treatment of BPD in a case that had been unresponsive to other psychological interventions.

Therapists need to complete lengthy and structured follow‐up to capture any emerging relapse.

Therapists need to discuss the patient’s thoughts and feelings about termination regularly in a relationally informed manner.
Identifying chromosomal introgressions from a wild species Arachis diogoi into interspecific peanut hybrids
Authors: Hanson Erik , Zhou Hai , Tallury Shyamalrau P. , Yang Xiping , Paudel Dev , Tillman Barry , Wang Jianping 
Published: May 2020

AbstractAn interspecific peanut hybrid population was generated from a cross between Arachis diogoi, a wild species with resistance to spotted wilt, and “Gregory”, a susceptible cultivar. The objectives of the study are to identify successful introgression of A. diogoi's genome and to evaluate the spotted wilt resistance in the introgression population. Sixty‐three putative introgression lines were genotyped using 137 polymorphic simple sequence repeat markers, out of which 14 markers located on seven of the 20 peanut chromosomes showed introgression of A. diogoi genome into at least one of the introgression lines. In addition, genotyping by sequencing of a subset of the population revealed SNP loci displaying introgression of A. diogoi genome on every chromosome of the A sub‐genome of the introgression lines, with the most introgressed loci on chromosome A05. Several introgression lines showed consistent spotted wilt resistance, suggesting successful genomic introgression of A. diogoi contributing to the resistance.
Survival of Curtobacterium flaccumfaciens pv. flaccumfaciens in weeds
Authors: Nascimento Daniele M. , Oliveira Letícia R. , Melo Luana L. , Silva João C. , Soman José M. , Girotto Karine T. , Eburneo Renan P. , Ribeiro‐Junior Marcos R. , Sartori Maria M. P. , Silva Júnior Tadeu A. F. , Maringoni Antonio C. 
Published: May 2020

AbstractWeeds are important alternative hosts of pathogens, responsible for the survival and spread of phytopathogenic bacteria. Our study evaluated the potential of weeds as hosts of Curtobacterium flaccumfaciens pv. flaccumfaciens (Cff), causal agent of bacterial wilt, one of the main diseases of common beans. Cff survival was evaluated in the phyllosphere and in the rhizosphere of 21 weeds, in four experiments under field conditions, during the years 2018 and 2019. The aerial part of the plant was inoculated by spraying bacterial suspension (107 cfu/ml) of Cff, while the soil of the growing pots was infested with the same suspension. Cff survival was evaluated every 7 days, for 70 days. The identity of the bacterium was confirmed by PCR with the specific primers CffFOR2 and CffREV4, from strains recovered from all samples. Principal component analysis (PCA) showed that high temperatures and rainfall reduced Cff survival in the phyllosphere, while high temperatures reduced the survival of the bacterium in the rhizosphere. Our results demonstrated that Amaranthus viridis (family Amaranthaceae), Conyza bonariensis, Emilia fosbergii, Galinsoga parviflora, Gnaphalium purpureum (Asteraceae), Raphanus sativus, Lepidium virginicum (Brassicaceae), Commelina benghalensis (Commelinaceae), Ipomoea triloba (Convolvulaceae), Cyperus rotundus (Cyperaceae), Senna obtusifolia (Fabaceae), Digitaria insularis (Poaceae), Nicandra physalodes, and Solanum americanum (Solanaceae) are potential hosts for Cff. Their eradication in common bean fields is recommended, especially in fields with a history of bacterial wilt occurrence.
The Third and Fatal Shock: How Pandemic Killed the Millennial Paradigm
Authors: Roberts Alasdair 
Published: May 2020

AbstractThis millennium began with widespread acceptance of a governing paradigm emphasizing small government, free markets, and open borders. Three crises—the 9/11 attacks, the 2008 financial crisis, and the 2020 COVID‐19 pandemic—forced American policy makers to diverge from this paradigm. At the time, these divergences were described as temporary departures from normalcy. In retrospect, it would be more accurate to regard the millennial paradigm itself as the abnormality: a model of governance designed for rare moments of calm. In the last two decades, a different paradigm has emerged. American government has become the ultimate bearer of societal risks. Repeatedly, it has adopted extraordinary measures to protect public safety and the economy. However, the American state lacks the capacity to anticipate and manage these massive risks competently. New capabilities are required, along with a new mentality about governing. Domestic politics will complicate the task of building these capabilities.
Alluvial architecture of mid‐channel fluvial–tidal barforms: The mesotidal Lower Columbia River, Oregon/Washington, USA
Authors: Prokocki Eric W. , Best James L. , Ashworth Philip J. , Sambrook Smith Gregory H. , Nicholas Andrew P. , Parsons Daniel R. , Simpson Christopher J. 
Published: May 2020

AbstractBarforms of mesotidal to macrotidal fluvial–tidal transitions, regardless of fluvial‐discharge, are currently thought to display a sedimentary architecture dominated by tidal signatures. Due to the scarcity of observations from modern mesotidal fluvial–tidal transitions, especially those of multi‐channelled large‐rivers (mean annual discharge ≥7000 m3 s−1 and peak discharges ≥15 000 m3 s−1) with mid‐channel bars, this concept remains unproven. The present study analyses data produced by a combination of high‐resolution ground penetrating radar and coupled shallow vibracores (<5 m depth), collected from modern fluvial–tidal mid‐channel bars of the mesotidal multi‐channelled Lower Columbia River, Washington/Oregon, USA, which can experience peak discharges ≥18 000 m3 s−1. These data were used alongside time‐sequenced aerial imagery to characterize the spatio‐temporal sedimentological evolution of these barforms in singular flows or combined flows consisting of river, tidal and/or wind‐wave oscillatory, current components operating in unique fluvial–tidal transition regimes. Results indicate that ca 75% of the Lower Columbia River fluvial–tidal transition produces braid‐bars with basal to bar‐top sedimentological architectures that are indistinguishable from fluvial‐only braid‐bars recorded in the literature. Barform stratal characteristics within the fluvial–tidal transitions of mesotidal large‐rivers are therefore more likely to be dominated by downstream‐oriented currents. Furthermore, a new style of low‐angle (<5°) inclined heterolithic stratification found in bar‐top accretion‐sets within upper‐mixed tidal–fluvial regime braid‐bars is observed. This common stratification is created by combined‐flows characterized by intrabasinal wind‐wave oscillatory‐currents and bidirectional tidal‐currents. This inclined heterolithic stratification marks the initial downstream fluvial–tidal crossover point from Lower Columbia River up‐dip fully‐fluvial braid‐bar architectures, to those possessing bar‐top facies produced by the hydraulic‐sedimentation response of combined intrabasinal wind‐wave and tidal influence. When preserved, this form of mid‐channel bar inclined heterolithic stratification provides a unique sedimentological signature of multi‐channelled fluvial–tidal transitions that possess an open‐water lower basin with intrabasinal wind‐waves.
Biomechanics of graded running: Part I ‐ Stride parameters, external forces, muscle activations
Authors: Vernillo Gianluca , Martinez Aaron , Baggaley Michael , Khassetarash Arash , Giandolini Marlene , Horvais Nicolas , Edwards William Brent , Millet Guillaume Y. 
Published: May 2020

Biomechanical alterations with graded running have only been partially quantified, and the potential interactions with running speed remain unclear. We measured spatiotemporal parameters, ground reaction forces, and leg muscle activations (EMG) in nineteen adults (10F/9M) running on an instrumented treadmills at 2.50, 3.33, and 4.17 m·s−1 and 0, ±5°, and ±10°. Step frequency illustrated a significant speed × grade interaction (P < .001) and was highest (+3%) at the steepest grade (+10°) and fastest speed (4.17 m·s−1) when compared to level running (LR) at the same speed. Significant interaction was also observed for ground reaction forces (all P ≤ .047). Peak ground reaction forces in the normal direction increased with running speed during downhill running (DR) only (+9% at −10° and 4.17 m·s−1). Impulse in the normal direction decreased at fastest speed and steepest DR (−9%) and uphill running (UR) (−17%) grades. Average normal loading rate increased and decreased at fastest speed and steepest DR (+52%) and UR (−28%) grades, respectively. Negative parallel impulse increased and decreased at fastest speed and steepest DR (+166%) and UR (−90%), respectively. Positive parallel impulse decreased and increased at fastest speed and steepest DR (−75%) and UR (+111%), respectively. EMG showed comparable u‐shaped curves across the grades investigated, although only a change in vastus lateralis and tibilias anterior activity was detectable at the steepest grades and fastest speed. Overall, running grade and speed significantly influences spatiotemporal parameters, ground reaction forces, and muscle activations.
Ecthyma gangrenosum without bacteremia in a 54‐year‐old woman with heart transplant
Authors: Hamed Almutasem , Niehaus Angela G. , Bosshardt Hughes Olivia , Jakharia Niyati 
Published: May 2020

AbstractEcthyma gangrenosum is a cutaneous manifestation of severe systemic pseudomonas infection and is commonly associated with bacteremia. It is common in immunocompromised patients with underlying neutropenia or leukopenia. We report a patient with heart transplant who developed a single lesion of ecthyma gangrenosum in the absence of bacteremia with a review of reported cases in solid organ transplant patients.
Are Exercise Referral Schemes Associated With an Increase in Physical Activity? Observational Findings Using Individual Patient Data Meta-Analysis From the National Referral Database
Authors: Rowley Nikita , Steele James , Wade Matthew , Copeland Robert James , Mann Steve , Liguori Gary , Horton Elizabeth , Jimenez Alfonso 
Published: May 2020

Objectives: To examine if exercise referral schemes (ERSs) are associated with meaningful changes in physical activity in a large cohort of individuals throughout England, Scotland, and Wales from The National Referral Database.Methods: Data were obtained from 5246 participants from 12 different ERSs, lasting 6–12 weeks. The preexercise referral scheme and changes from the preexercise to the postexercise referral scheme in self-reported International Physical Activity Questionnaire scores were examined. A 2-stage individual patient data meta-analysis was used to generate the effect estimates.Results: For the pre-ERS metabolic equivalent (MET) minutes per week, the estimate (95% confidence interval [CI]) was 676 MET minutes per week (539 to 812). For the change in MET minutes per week, the estimate (95% CI) was an increase of 540 MET minutes per week (396 to 684). Changes in the total PA levels occurred as a result of increases in vigorous activity of 17 minutes (95% CI, 9 to 24), increases in moderate activity of 29 minutes (95% CI, 22 to 36), and reductions in sitting of −61 minutes (95% CI, −78 to −43), though little change in walking (−5 min; 95% CI, −14 to 5) was found.Conclusions: Most participants undergoing ERSs are already “moderately active.” Changes in PA behavior associated with participation are through increased moderate to vigorous PA and reduced sitting. However, this was insufficient to change the International Physical Activity Questionnaire category, and the participants were still “moderately active.”
Modulation of zircon solubility by crystal–melt dynamics
Authors: Szymanowski Dawid , Forni Francesca , Wolff John A. , Ellis Ben S. 
Published: May 2020

Abstract
Zircon dating is commonly used to quantify timescales of magmatic processes, but our appreciation of the consequences of internal magma body dynamics lags behind ever-increasing analytical capabilities. In particular, it has been shown that crystal accumulation and melting of cumulates by recharge-delivered heat may affect melt chemistry within magma bodies. We considered the effect of such processes on zircon solubility in highly evolved silicate melts of diverse chemical affinities. Our modeling shows that in most cases cumulate melting perpetuates the zircon saturation behavior of the first melts emplaced at shallow storage levels. Once cumulate melting is established, the ease of saturating in zircon is controlled by cumulate mineralogy, with a particular effect of the amount of cumulate zircon and its availability for resorption. The fidelity of zircon as a recorder of magma system history thus depends on both the system’s chemical affinity and mineralogy, and the history itself.