bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gd‐doped (Pb, La)(Zr, Sn, Ti)O3 antiferroelectric ceramic dielectric materials for high power energy storage capacitor
Authors: Zhou Jian , He Chenchen , Yu Zemin , Liu Deke , Zhang Kai , Xu Ran 
Published: December 2024

AbstractLead‐based antiferroelectric materials have recently demonstrated significant potential in key components of electrical and electronic systems due to their swift charge‐discharge rates. However, achieving a combination of high energy density and ultrahigh power density poses a significant challenge for practical applications in cutting‐edge energy storage devices. Hence, the authors’ present an integrated strategy to simultaneously achieve the high energy density and ultrahigh power density in the (Pb1‐1.5xGdx)(Zr0.57Sn0.35Ti0.08)O3 ceramic through tape‐casting methods. The introduction of Gd3+ dopant at the A‐site not only effectively narrows the P‐E curve by lowering the energy barriers of the phase transitions but also reduces oxygen vacancies, refining the average grain size in the crystalline structure, which leads to obtaining the high‐density grain boundaries and enhances the dielectric breakdown strength. As a result, a high energy storage density of 4.99 J/cm3 and an ultrahigh power density of 98.51 MW/cm3 are achieved in (Pb0.94Gd0.04)(Zr0.57Sn0.35Ti0.08)O3 (PG4ZST) ceramics under their respective maximum applied field, proving the effectiveness of our integrated strategy. Excellent temperature stability from the ambient temperature to 140°C is also obtained. This study confirms that the authors’ integrated strategy provides a way to enhance the high‐performance dielectrics of lead‐based ceramics for energy storage and other related applications.
Alfvén continuum modes around an X-point with a guide field
Authors: Geeraerts M. , Afanasyev A. , Sadeghi M. , Van Doorsselaere T. 
Published: December 2024

Context. Oscillations around X-points are important for the local heating of the coronal plasma by magnetic reconnection and for the generation of quasi-periodic pulsations in solar flares. The processes of phase mixing and resonant absorption are of particular interest in this context.
Aims. The aim of this paper is to find the Alfvén continuum eigenmodes around an X-point with a guide field, as these modes are particularly important for phase mixing and resonant absorption.
Methods. We studied the linear oscillations in the neighborhood of an X-point with the use of flux coordinates. Reduced equations that describe continuum oscillations were used to determine the Alfvén continuum modes both with and without a guide field in the direction normal to the X-point plane.
Results. We determined Alfvén continuum mode solutions in the form of analytical solutions for the special case without a guide field. We also derived numerical solutions in the more general case with a guide field under the assumption of pressureless plasma.
Prenatal imaging – role of fetal MRI
Authors: Tavares de Sousa Manuela , Schönnagel Björn P. , Denecke Jonas , Herrmann Jochen 
Published: December 2024

AbstractCongenital abnormalities occur in about 3 in 100 fetuses. Prenatal ultrasound is the standard technique to detect these fetal abnormalities. In Germany, three ultrasound examinations are provided in the first, second, and third trimesters, respectively. Fetal magnetic resonance imaging (MRI) can be used as an adjunct technique to provide further information in cases of congenital abnormalities.A literature search was performed on PubMed focusing on publications that used fetal MRI as a secondary approach after prenatal ultrasound.MRI is a safe imaging method that does not harm the fetus when used during pregnancy. Some publications with experts in radiology show a very clear diagnostic advantage with respect to performing MRI on fetuses with brain abnormalities, while other publications with experts in neurosonography do not find the advantage to be that evident. Both techniques are clearly user-dependent.Fetal MRI can supplement the information obtained by fetal ultrasound and can provide additional information or exclude others. Diagnosis made by an interdisciplinary cooperation based on all available ultrasound and MRI findings is the key to optimal imaging and advice for expectant parents.
Kompetenzorientiert und transtheoretisch? Ideen und Hürden für die
psychotherapeutische Aus- und Weiterbildung
Authors: von Blanckenburg Pia , Wilhelm Marcel , Rief Winfried 
Published: December 2024

Zusammenfassung
Hintergrund Die Aus- und Weiterbildung von Psychotherapeut:innen erfolgt
meistens auf der Grundlage einer verfahrensspezifischen theoretischen
Ausrichtung. Dies kann jedoch den Austausch und die gemeinsame Nutzung von
Wissen und Erfahrungen einschränken. Es könnte daher hilfreich sein,
verschiedene theoretische Ansätze zu kombinieren und die psychotherapeutische
Ausbildung transtheoretisch und verfahrensübergreifend auszurichten.
Methode Der Artikel beschreibt, wie eine kompetenzorientierte
psychotherapeutische Ausbildung als Plattform für den Austausch
unterschiedlicher Therapieansätze genutzt werden könnte. Anhand eines
Praxisbeispiels aus der universitären Ausbildung werden Wege aufgezeigt,
psychotherapeutische Grundkompetenzen durch die Integration verschiedener
theoretischer Ansätze zu vermitteln. Eine transtheoretische Ausbildung erfordert
zunächst ein übergeordnetes Modell zur Fallkonzeptualisierung sowie eine klare
Definition der Interventionsziele, die nicht an ein spezifisches Verfahren
gebunden sind.
Ergebnisse Behandlungsmethoden sollten anhand ihrer transtheoretischen
Ziele klassifiziert werden, um sie leichter vergleichen und kombinieren zu
können. Dynamische Netzwerkmodelle bieten hier eine moderne Möglichkeit für die
transtheoretische Fallkonzeptualisierung. Wir stellen einen
kompetenzorientierten Ansatz zur psychotherapeutischen Ausbildung im
universitären Kontext vor und diskutieren die Herausforderungen einer
kompetenzorientierten Weiterbildung.
Schlussfolgerung Ein kompetenzorientierter Ansatz könnte dazu beitragen,
die Distanz zwischen verschiedenen psychotherapeutischen Traditionen zu
verringern. Dieser Ansatz versteht sich als Ergänzung bestehender Verfahren,
nicht als deren Ersatz. Dennoch bleiben einige Herausforderungen zu
bewältigen.
FHIR – Overdue Standard for Radiology Data Warehouses
Authors: Arnold Philipp , Pinto dos Santos Daniel , Bamberg Fabian , Kotter Elmar 
Published: December 2024

AbstractIn radiology, technological progress has led to an enormous increase in data volumes. To effectively use these data during diagnostics or subsequent clinical evaluations, they have to be aggregated at a central location and be meaningfully retrievable in context. Radiology data warehouses undertake this task: they integrate diverse data sources, enable patient-specific and examination-specific evaluations, and thus offer numerous benefits in patient care, education, and clinical research.The international standard Health Level 7 (HL7) Fast Healthcare Interoperability Resources (FHIR) is particularly suitable for the implementation of such a data warehouse. FHIR allows for easy and fast data access, supports modern web-based frontends, and offers high interoperability due to the integration of medical ontologies such as SNOMED-CT or RadLex. Furthermore, FHIR has a robust data security concept. Because of these properties, FHIR has been selected by the Medical Informatics Initiative (MII) as the data standard for the core data set and is intended to be promoted as an international standard in the European Health Data Space (EHDS).Implementing the FHIR standard in radiology data warehouses is therefore a logical and sensible step towards data-driven medicine.
Redes neurais convolucionais no diagnóstico de mielopatia cervical
Authors: Korkmaz Murat , Yılmaz Hakan , Korkmaz Merve Damla , Akgül Turgut 
Published: December 2024

Resumo
Objetivo As tecnologias de inteligência artificial são cada vez mais utilizadas em cirurgias de coluna como ferramentas diagnósticas. O objetivo do presente estudo foi avaliar a eficácia das redes neurais convolucionais no diagnóstico da mielopatia cervical (MC) em comparação à ressonância magnética (RM) cervical convencional.
Métodos O presente estudo foi transversal, descritivo e analítico. Cento e vinte e cinco participantes com diagnóstico clínico e radiológico de MC foram incluídos no estudo. Foram utilizadas imagens de RM sagital e axial em sequência ponderada em T2 da coluna cervical. Todas as imagens foram obtidas em 8 bits/pixel em duas categorias diferentes (MC e normal), tanto em vistas axiais quanto sagitais.
Resultados A validação transversal tripla evitou o sobreajuste (overfitting) durante o processo de treinamento. Duzentas e quarenta e duas imagens foram utilizadas para treinamento e teste do modelo criado para vistas axiais, que apresentou 97,44% de sensibilidade e 97,56% de especificidade. Duzentas e quarenta e nove imagens foram utilizadas para treinamento e teste do modelo criado para vistas sagitais, que apresentou 97,50% de sensibilidade e 97,67% de especificidade. Após o treinamento, a acurácia média foi de 96,7% (±1,53) para a vista axial e de 97,19% (±1,2) para a vista sagital.
Conclusão O deep learning (DL) apresentou grande melhora, especialmente na cirurgia de coluna. Observamos que a tecnologia de DL trabalha com maior acurácia do que em outros estudos na literatura para diagnóstico de MC.
Avaliação clínica comparativa de duas técnicas no tratamento artroscópico das lesões parciais articulares do manguito rotador após seis anos de seguimento
Authors: Sella Guilherme do Val , Silva Luciana Andrade da , Okamoto Ricardo Makoto , Marmille Hector Carmona , do Val Pedro Gabriel Pelegrino , Miyazaki Alberto Naoki 
Published: December 2024

Resumo
Objetivo Avaliar clinicamente a médio prazo os resultados do tratamento artroscópico das lesões parciais da porção articular do manguito rotador (LPPAMR) pelas técnicas de reparo transtendão (RTT) e reparo após completada a lesão (RPCL) utilizando-se a Escala Modificada de Avaliação do Ombro da University of California, Los Angeles (UCLA), a escala de Constant-Murley e análise de força.
Métodos Estudo retrospectivo de reavaliação, após seguimento mínimo de 6 anos, de casos de LPPAMR operados artroscopicamente, envolvendo um total de 34 pacientes, sendo 18 submetidos ao RTT e 16 ao RPCL. Foram comparadas as pontuações atuais nas escala da UCLA e de Constant-Murley, a força média entre as técnicas, e as pontuações na UCLA atualmente e com 2 anos de pós-operatório do mesmo grupo, conforme publicado em estudo anterior, a fim de avaliarmos se houve ou não modificação dos resultados ao longo do tempo.
Resultados Não houve diferença estatística entre as pontuações nas escalas. As pontuações na escala da UCLA atual foram de 33,8 para o RTT e de 32,9 para o RPCL (p = 0,113), e na escala de Constant-Murley, foram de 91,9 e 86,8, respectivamente (p = 0,075). Para o RTT, a pontuação anterior na escala da UCLA (com 2 anos de pós-operatório) foi 32,4, e a atual, de 33,8 (p = 0,374); para o RPCL, foi de 32,4 com 2 anos de pós-operatório, e de 32,9 atualmente (p = 0,859). No RTT, a força média foi estatisticamente maior do lado dominante (11 kg) do que no não dominante (7,80 kg) (p = 0,023) e aqueles do RPCL (8,25 kg) (p = 0,042).
Conclusão Não houve diferença estatística em médio prazo na comparação das pontuações nas escalas da UCLA e de Constant-Murley em relação à técnica utilizada (RTT ou RPCL), nem alteração nas pontuações na escala da UCLA entre 2 e 6 anos de pós-operatório. Nos pacientes submetidos à RTT, a força média foi estatisticamente maior do lado dominante do que no não dominante, e maior do que nos pacientes submetidos à RPCL.
Prótese de polipropileno no tratamento de lesões extensas e cobertura de áreas doadoras sem enxerto: Série de casos
Authors: Uchôa Raphael De Sá Vasconcelos , Ferreira Luís Filipe e Silva Lessa , Uchôa Ana Luiza Simões de Brito 
Published: December 2024

Resumo
Objetivo Avaliar a eficácia do uso das próteses de polipropileno no tratamento de ferimentos extensos nos membros.
Métodos Foram avaliados 13 pacientes quanto aos aspectos finais do tratamento, incluindo presença de epitelização e granulação, redução de área cruenta e cobertura de estruturas profundas.
Resultados Uma redução maior que 40% da área cruenta e cobertura completa de estruturas nobres foram visualizadas.
Conclusão Evidenciou-se uma alternativa eficaz, reprodutível e de baixo custo no tratamento de lesões extensas.
Diagnóstico das lesões meniscais em rampa
Authors: Jorge Pedro Baches , Oliveira Diego Escudeiro de , Mussatto Guilherme do Amaral , Horita Melanie Mayumi , Salas Victor Eduardo Roman , Jorge Rafael Baches 
Published: December 2024

Resumo
Objetivo: Comparar os métodos diagnósticos para lesão meniscal em rampa (ressonância magnética, artrotomografia e artroscopia) evidenciando qual o método mais sensível e qual o grau de concordância entre os métodos.
Método: Foram estudados 21 pacientes, sendo esses, jovens, atletas, com suspeita de lesão do LCA após trauma há pelo menos 3 meses, sem evidências ou histórico de outras lesoes osteoarticulares no joelho. Para isso os pacientes foram submetidos a ressonância magnética, artrotomografia e após a confirmação da lesão do LCA foi realizada artroscopia para reconstrução ligamentar e avaliação do menisco medial para confirmar ou excluir o diagnóstico de lesão em rampa. Os métodos diagnósticos foram comparados pelo teste de concordância de McNemar, sendo também avaliada especificidade e sensibilidade, utilizando como padrão ouro a artroscopia, com intervalo de confiança de 95% e p < 0,005.
Resultado: Os resultados foram semelhantes com os já encontrados na literatura. A ressonância magnética apresentou sensibilidade de 73,3% e especificidade de 83,3%, com uma concordância de 76,2% com o padrão ouro. Já a artrotomografia apresentou sensibilidade e especificidade de 100% e 66,7% respectivamente, com uma concordância de 90,5% com a artroscopia.
Conclusão: Neste trabalho, a artrotomografia se apresentou como o método diagnóstico mais sensível e com maior concordância com o padrão ouro, devendo ser considerada na investigação diagnóstica de pacientes com lesão do LCA.
Automated Assessment of Sarcopenia with Hounsfield Unit Average Calculation in Computed Tomography Scans Using Deep Learning Techniques
Authors: Rengan Vinayak , Meenashi Sundaram Pravin , Arora Eham , Ravanasamudram Sitaraman Rengan , Sekaran Praveen , Kalla Rohit , Bawa Ashvind , Alexander Naveen , Ramanan Rochita V. 
Published: December 2024

Abstract
Introduction Skeletal muscle is increasingly plastic with an ability to gain or lose tissue. Depletion of muscle mass and quality occurs due to various factors such as aging, disease, and disuse. Sarcopenia can be loosely defined as a significant loss of muscle mass and function. Sarcopenia is now recognized as an independent risk factor for various patient-related negative outcomes after various surgeries. Various computed tomography (CT) based imaging indices for assessment of sarcopenia exist in practice. The psoas muscle Hounsfield unit average calculation (HUAC) has been proven to be an effective one as it is independent of patient anthropometric data, and it can be calculated in the images provided.
Aim The aim of this study is to develop automated tools for estimation of the HUAC using deep learning algorithms.
Materials and Methods A total of 41 abdominal CTs were used. Ground truth was established and validated by two radiologists with more than 5 and 10 years of experience each. Models were trained to identify the psoas muscle among the slices and calculate the HUAC.
Results At inference, an average intersection over union (IoU) value of 90% was obtained between the deep learning model outputs and the original annotated test images for the CT slices. The Dice coefficient was 0.90 between the ground truth labels and the output from the model.
Conclusion We have demonstrated the accuracy of our deep learning–based algorithm for quantifying the psoas muscle HUAC, which is a marker for sarcopenia. There is a potential for a fully automated measure to calculate the HUAC for any patient undergoing CT scan.
High Success Rate in Sealing Distal Coronary Artery Perforations Using Absorbable Gelatin Sponge
Authors: Hashemi Arash , Serati Alireza , Ahmadieh Arsis , Ghaffari Lida , Movahed Mohammad R. 
Published: December 2024

AbstractCoronary artery perforation (CAP) is a major complication of percutaneous coronary intervention (PCI). The management of CAP can be challenging, requiring tailored approaches based on specific clinical scenarios. We are reporting outcome data on six patients who experienced distal CAP during PCI and were 100% successfully treated using absorbable gelatin sponge embolization without procedural or immediate postprocedural complications.
Pediatric human immunodeficiency virus-positive disclosure status and associated factors among caregivers of children in Wolaita and Hadiya zone, southern Ethiopia
Authors: Tesfaye Lina , Abebe Amene , Molla Simegn , Admasu Amare 
Published: December 2024

AbstractBackgroundHuman immunodeficiency virus (HIV) positive status disclosure is an essential component of pediatric care and long-term disease management. However, pediatric HIV disclosure is a complex and understudied public health concern. This study aimed to assess the pediatric HIV-positive disclosure status and associated factors among caregivers.MethodA facility-based cross-sectional study was done among 375 caregivers of HIV-positive children in selected facilities from March 1 to April 30, 2022. Data was collected through inperson interviews using a carefully designed questionnaire that had been tested beforehand. Study participants were randomly selected from the anti-retroviral therapy (ART) logbook using a lottery method as the sampling frame. The data collected was inputted into Epidata version 3.02 and then transferred to SPSS version 23 for analysis. The findings were displayed through tables, graphs, charts, and written descriptions. Statistical analyses using different models were performed to examine the data. The association of variables was declared at 95%CI and p-value <0.05 and the strength of association was determined using the adjusted odds ratio (AOR).ResultOut of 371 participants, 98.9% replied to the survey. Forty-one point eight percent of caregivers told them about their HIV-positive children’s status. Caregivers/parents’ discussions with health care providers about disclosure [AOR 2.171, 95% CI [1.199, 3.931]], child duration on ART [AOR 1.633, 95% CI [1.013, 2.631]], and child stigmatization [AOR 2.103, 95% CI [1.361, 3.250]] were significantly associated with pediatric HIV positive status disclosure.ConclusionThe rate of disclosing pediatric HIV-positive status was lower compared to other studies in Ethiopia. Caregivers who talked to healthcare providers, children on ART for a longer time, and caregivers not fearing stigma for their child were more likely to disclose pediatric HIV-positive status. Facility management and healthcare providers should focus on improving the disclosure of pediatric HIV-positive status.
Combined inhibition of MDM2 and PARP lead to a synergistic anti-tumoral response in p53 wild-type rhabdomyosarcoma models
Authors: Pons Guillem , Zarzosa Patricia , Gallo-Oller Gabriel , Wenz Amelie , Lapins Maris , García-Gilabert Lia , Sansa-Girona Júlia , Navarro Natalia , Segura Miguel F. , Soriano Aroa , Guillén Gabriela , Hladun Raquel , Sánchez de Toledo Josep , Gallego Soledad , Carreras-Puigvert Jordi , Moreno Lucas , Roma Josep 
Published: December 2024

AbstractTargeting MDM2-p53 interaction to enhance p53 activity represents a promising antitumoral strategy for p53 wild-type pediatric tumors, including soft-tissue sarcomas. However, results from early-phase clinical trials in hematological and solid cancers have shown limited efficacy of MDM2 inhibitors, underscoring the necessity to explore more effective combinations with other agents. In this study, we provide results from a 22-drug combination screening demonstrating the therapeutic potential of combining siremadlin (MDM2 inhibitor) and olaparib (PARP inhibitor) for treating p53 wild-type rhabdomyosarcoma (p53 WT RMS). Cell survival, cell death, and apoptosis analysis revealed synergistic effects of combining siremadlin plus olaparibin vitro. The combination of both drugs led to a significant increase in p53 activity, as evidenced by p53 accumulation and K382 acetylation, along with an increased expression of bona fide p53 targets. Furthermore, treatment with both drugs resulted in significant reduction of tumor growth and increased mice overall survival when compared to single treatments and control in cell line-derived orthotopic xenograft models. Overall, our study demonstrates, for the first time, the synergistic effect of combining siremadlin plus olaparib in inhibiting p53 WT RMS tumor growthin vitroandin vivo. Our findings support the potential to study the combination of both drugs in clinical trials and warrants further investigation in other tumors with similar molecular features.
RNA-programmable cell type monitoring and manipulation in the human cortex with CellREADR
Authors: Matthews Elizabeth A. , Russ Jeffrey B. , Qian Yongjun , Zhao Shengli , Thompson Peyton , Methani Muhib , Vestal Matthew L. , Huang Z. Josh , Southwell Derek G. 
Published: December 2024

AbstractReliable and systematic experimental access to diverse cell types is necessary for understanding the neural circuit organization, function, and pathophysiology of the human brain. Methods for targeting human neural populations are scarce and currently center around identifying and engineering transcriptional enhancers and viral capsids. Here we demonstrate the utility of CellREADR, a programmable RNA sensor-effector technology that couples cellular RNA sensing to effector protein translation, for accessing, monitoring, and manipulating specific neuron types inex vivohuman cortical tissues. We designed CellREADR constructs to target two distinct human neuron types,CALB2+(calretinin) GABAergic interneurons andFOXP2+ (forkhead box protein P2) glutamatergic projection neurons, and validated cell targeting using histological, electrophysiological, and transcriptomic methods. CellREADR-mediated expression of optogenetic effectors and genetically-encoded calcium indicators allowed us to manipulate and monitor these neuronal populations in cortical microcircuits. We further demonstrate that AAV-based CellREADR and enhancer vectors can be jointly used to target different subpopulations in the same preparation. By demonstrating specific, reliable, and programmable experimental access to targeted cell types, our results highlight CellREADR’s potential for studying human neural circuits and treating brain disorders with cell type resolution.