bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jacqueline Dreyfus, bibliothécaire et conteuse
Authors: Lebarbier Micheline 
Published: December 2020

À partir de documents conservés dans le fonds patrimonial Heure joyeuse à la médiathèque Françoise‑Sagan, est exhumée la vie et l’œuvre de Jacqueline Dreyfus, qui fut l’une de ses stagiaires. Elle fut l’une des premières bibliothécaires pour enfants pendant la période de l’entre‑deux‑guerres et eut à cœur de leur transmettre le goût de la littérature, tant à travers la lecture qu’à travers l’audition de contes et d’histoires lues ou racontées. Formée à l’art de raconter lors des séances de l’Heure du conte à la bibliothèque L’Heure joyeuse de la rue Boutebrie, elle transporta ce « savoir conter » dans les deux bibliothèques (rue de Ménilmontant et rue Fessart) dont elle eut la charge au cours des années 1931‑1937. Dans ses notes et comptes rendus sont consignés la vie de ces bibliothèques, ses joies et ses doutes en tant que conteuse et ses interactions avec ses jeunes lecteurs/auditeurs. Constamment soucieuse de la transmission orale qu’elle leur offrait, souvent imparfaite à ses yeux, elle n’eut de cesse de leur présenter la quintessence de la littérature enfantine de l’époque, tant par le livre que par l’oralité. Elle disparut à Auschwitz en 1943.
Les contes de fées, ça c’est beau !!!!
Authors: Belmont Nicole 
Published: December 2020

Cet article tente de suivre la création et l’évolution d’une pratique inédite en France à cette époque tourmentée et pleine d’espoirs nouveaux, celle de l’entre‑deux‑guerres (1924‑1939). Il s’agit de la pratique du contage aux enfants, dans un cadre lui aussi inédit : une bibliothèque qui leur est exclusivement consacrée, L’Heure joyeuse. Suivant l’exemple des États-Unis, les deux activités sont corollaires, l’une ne va pas sans l’autre. Les réactions des enfants à l’Heure du conte sont notées très soigneusement et analysées : il s’agit d’abord de susciter leur plaisir à l’écoute, voire leur enthousiasme, souvent attesté et qui s’inscrit dans le partage entre enfants et conteuse. On y remarque peu d’intention pédagogique manifeste, sinon parfois un retour spontané vers le livre dont a été tiré le conte dit. À un niveau plus profond, il s’agit d’amener l’enfant vers une rêverie poétique et créatrice au sens où l’entend G. Bachelard.
Methylation-Sensitive Restriction Enzyme Quantitative Polymerase Chain Reaction Enables Rapid, Accurate, and Precise Detection of Methylation Status of the Regulatory T Cell (Treg)-Specific Demethylation Region in Primary Human Tregs
Authors: Perry Nicholas , Wasko Kevin , Cheng Jason , Tabbaa Diana , Marco Eugenio , Giannoukos Georgia , Albright Charles F , Borges Christopher M 
Published: December 2020

Abstract
Human regulatory T cells (Tregs) have been implicated in cancer immunotherapy and are also an emerging cellular therapeutic for the treatment of multiple indications. Although Treg stability during ex vivo culture has improved, methods to assess Treg stability such as bisulfite Sanger sequencing to determine the methylation status of the Treg-specific demethylated region (TSDR) have remained unchanged. Bisulfite Sanger sequencing is not only costly and cumbersome to perform, it is inaccurate because of relatively low read counts. Bisulfite next-generation sequencing, although more accurate, is a less accessible method. In this study, we describe the application of methylation-sensitive restriction enzymes (MSRE) and quantitative PCR (qPCR) to determine the methylation status of the TSDR. Using known ratios of Tregs and non-Tregs, we show that MSRE-qPCR can distinguish the methylation status of the TSDR in populations of cells containing increasing proportions of Tregs from 0 to 100%. In a comparison with values obtained from an established bisulfite next-generation sequencing approach for determining the methylation status of the TSDR, our MSRE-qPCR results were within 5% on average for all samples with a high percentage (&gt;70%) of Tregs, reinforcing that MSRE-qPCR can be completed in less time than other methods with the same level of accuracy. The value of this assay was further demonstrated by quantifying differences in TSDR methylation status of Tregs treated with and without rapamycin during an ex vivo expansion culture. Together, we show that our novel application of the MSRE-qPCR to the TSDR is an optimal assay for accurate assessment of Treg purity.
Cutting Edge: Severe SARS-CoV-2 Infection in Humans Is Defined by a Shift in the Serum Lipidome, Resulting in Dysregulation of Eicosanoid Immune Mediators
Authors: Schwarz Benjamin , Sharma Lokesh , Roberts Lydia , Peng Xiaohua , Bermejo Santos , Leighton Ian , Casanovas-Massana Arnau , Minasyan Maksym , Farhadian Shelli , Ko Albert I ,   Yale IMPACT Team, Dela Cruz Charles S , Bosio Catharine M 
Published: December 2020

Abstract
The COVID-19 pandemic has affected more than 20 million people worldwide, with mortality exceeding 800,000 patients. Risk factors associated with severe disease and mortality include advanced age, hypertension, diabetes, and obesity. Each of these risk factors pathologically disrupts the lipidome, including immunomodulatory eicosanoid and docosanoid lipid mediators (LMs). We hypothesized that dysregulation of LMs may be a defining feature of the severity of COVID-19. By examining LMs and polyunsaturated fatty acid precursor lipids in serum from hospitalized COVID-19 patients, we demonstrate that moderate and severe disease are separated by specific differences in abundance of immune-regulatory and proinflammatory LMs. This difference in LM balance corresponded with decreased LM products of ALOX12 and COX2 and an increase LMs products of ALOX5 and cytochrome p450. Given the important immune-regulatory role of LMs, these data provide mechanistic insight into an immuno-lipidomic imbalance in severe COVID-19.
Heterotopic ossification in a patient with diffuse idiopathic skeletal hyperostosis: Input from histological findings
Authors: Licini Caterina , Farinelli Luca , Cerqueni Giorgia , Hosein Andrell , Marchi Saverio , Gigante Antonio , Mattioli-Belmonte Monica 
Published: December 2020

A high incidence of heterotopic ossification (HO) has been reported in patients with diffuse idiopathic skeletal hyperostosis (DISH), a metabolic disease characterized by calcifications of entheses at spine and peripheral sites. We performed histological and immunohistochemical analyses in five different HO sites in a patient with DISH to study a possible mutual interaction of bone morphogenetic protein 2 (BMP-2), transforming growth factor beta (TGF-β), and decorin, crucial for bone mass increasing, matrix calcification, and endochondral bone formation. We speculated that the surgical trauma triggered HO, inducing TGF-β release at the lesion site. TGF-β recruits osteoblast precursor cells and determines the overexpression of BMP-2 in the surrounding skeletal muscle, inducing a further osteogenic differentiation, contributing to HO onset.
Function analysis of the calls of Dendropsophus microps of the Campos do Jordão State Park, São Paulo, Brazil
Authors: Toledo Maysa Hernandes Ricardo , Martins Itamar Alves 
Published: December 2020

In this study, we describe the calls emitted by Dendropsophus microps, a species of frog in the family Hylidae, in Serra da Mantiqueira, Campos do Jordão, São Paulo, Brazil, and evaluate their functions in the social context using playback experiments. Between October 2016 and November 2017, 15 males of D. microps were recorded. Six hundred and five calls were analyzed and the existence of five types of call compositions was verified: simple call “A normal”; compound call “Af”; shorter “A” call + longer “A” call; “A + Af” calls; and simple call “B”; demonstrating the presence of compound calling in the vocalization structure. One thousand, six hundred and seventeen calls were recorded during the playback experiment in response to the 5 previously constructed stimuli. The “B” call was the most emitted in response to stimuli. The “A”, “Af”, “AA” and “AAf” stimuli caused visual signaling. We recorded a series of 4 to 5 “A” calls during agonistic interactions. Call "B" was identified as an advertisement call and calls "A", "Af", "AA" and "AAf" as aggressive calls. The presence of visual communication in addition to the acoustic communication of these individuals was also observed. The findings increase knowledge of the calling repertoire of this species and can be used in the future in other behavioral and taxonomic studies.
Evaluation by Multivariate Statistical Methods of Relationship with Physicochemical Properties of Humic Acid and Some Soil
Authors: Mehmet DÜZGÜN  , Uğur BİLGE  , M. Zahir DÜZ  
Published: December 2020

Humic acid is a very important component for soil. In particular, It is an important factor for regulation of plant nutrients. In this study, HA (humic acid) contents of soil samples taken from 12 different locations were determined by appropriate method. After extracting the humic acid from the soil samples, the remaining soil elements concentrations were determined by ICP-OES method. In addition, the element concentrations in the humic acid fraction were determined by the same method. In soil samples were determined organic matter (OM), pH, EC, clay, silt and sand. The relationships between all variables were evaluated by multivariate statistical analysis such as correlation, simple linear regression, PCA (Principal Component Analysis). Spearman rho coefficient was taken into consideration in the correlation analysis. Simple linear regression analysis showed significant regression model between HA and OM, pH, HAfMn (HAf: humic acid fraction), HAfSe, HAfP, TfCd (Tf:soil fraction), TfMn, TfPb, TfSe. In the PCA analysis, 4 factors were found to explain 88.23% of the total change. P1:OM, TPb, TSe, HA P2:TAs, TSb, TBa, TMn, TFe P3: TCd, TP, pH, TSn, Silt, TAl P4: Kil, sand, TBe, EC. In the correlation analysis (N: 12), HA was significant positive with TfSe (r= 0.615, P <0.05), and significant negative with HAfBe (r= -0.786, P <0.01) and significant positive with HAfMn (r= 0.918, P <0.01) and significant negative with HAfSn (r= -0.700, P <0.05) and significant positive with HAfSe (r= 0.704, P <0.05) and significant positive with HAfP (r= 0.700, P <0.05) correlation was found.
Bazı Yerel Çerezlik Ayçiçeği (Helianthus annuus L.) Populasyonlarında Verim ve Verim Öğelerinin Belirlenmesi
Authors: Levent YAZİCİ  
Published: December 2020

Bu çalışmada, Türkiye’nin farklı bölgelerinden toplanan bazı yerel çerezlik ayçiçeği popülasyonların Tokat ekolojik koşullarında verim ve verim unsurlarının belirlenmesi amaçlanmıştır. Araştırma Tokat-Kazova ekolojik koşullarında dikdörtgen latis deneme desenine” göre, 3 tekerrürlü olarak, 2 yıl süre ile yürütülmüştür. Araştırmada bitki boyu, tabla çapı, tane eni, tane boyu, 1000 tane ağırlığı ve tohum verimi incelenmiştir. Projede materyal olarak ülkemizin farklı bölgelerinden toplanmış, 20 adet çerezlik ayçiçeği yerel populasyonu ile standart olarak iki adet tescilli çeşit kullanılmıştır. İki yılın ortalama sonuçlarına göre; bitki boyu değerleri 154.3-265.4 cm arasında, tabla çapı 17.0-22.2 cm, tane eni 7.9-9.6 mm, tane boyu 20.4-25.9 mm, 1000 tane ağırlığı 122.2-167.1 g ve tohum verimi 180.4-474.0 kg/da arasında değişmiştir. Araştırmada incelenen özellikler birlikte değerlendirildiğinde 16, 3, 10, 13 ve 14 no’lu populasyonların ön plana çıktığı görülmüştür.
O discurso sem palavra Uma outra dimensão da linguagem
Authors: Rodrigues Fabiano de Abreu 
Published: December 2020

GUALBERTO, Pablo Henrique Silva de Araujo. Psicanálise existencial: Uma proposta sartriana de assumir-se enquanto sujeito. 2020. Número total de folhas. Trabalho de Conclusão de Curso de Psicanálise Clínica – Instituto GAIO Ensino Superior. Belo Horizonte, 2020.
Jean-Paul Sartre, em determinado momento, dá a sua visão e reformula a teoria psicanalítica desenvolvida por Sigmund Freud, colocando o sujeito em uma posição mais ativa e não empírica; desta maneira, Sartre nos diz que o homem é aquilo que faz com o que fazem dele, por ele e/ou com ele, afastando-se, então, da proposta freudiana do inconsciente.
Child nutrition process and habits of a food doctrine for a lifetime
Authors: Rodrigues Fabiano de Abreu 
Published: December 2020

Food defines, helps and influences our quality of life as well as our longevity. A Poor nutrition in childhood can reflect in problems later in adulthood with consequences in old age, just as a poor diet in adulthood can reflect in problems in old age, an adequate nutrition can increase longevity as well as quality of life. Taking into account the increase in the age group of the elderly, the need for adequate nutrition to prevent and combat age limitations, deficiencies and typical diseases of aging also increases.
The objective of this work is not to create an idea that we have to live a whole life since childhood as machines that feed in an indoctrinated way to have a better old age, but to present types of diets as options, where nutrition is favorable and fun. It is the habits that we introduce since breastfeeding and childcare that educate the child to become an adult with good eating habits.
Based on the knowledge of neuroscience, neuropsychology, psychoanalysis and clinical nutrition, present diets, preventions, examples and explanations that favor the understanding of the need and results of good nutrition. Some key points will assist us in this nutritional summary in this work:

Child nutrition options to help in a good childhood.
Habits and techniques for a fun and enjoyable nutrition.
How nutrition helps in mood and learning.
MENINGKATKAN KREATIFITAS MAHASISWA MELALUI MODEL PEMBELAJARAN KOOPERATIF TIPE STUDENT TEAMS ACHIEVEMENT DIVISION
Authors: Fatmawati Suci 
Published: December 2020

Pembelajaran yang berkualitas bergantung pada metode pembelajaran yang digunakan oleh Dosen dalam mentransfer ilmu, oleh karena itu metode kooperatif menjadi salah satu alternatif pembelajaran yang diteliti dalam mengukur kreativitas mahasiswa. Tujuan Penelitian ini ialah untuk mengetahui perbedaan kreativitas mahasiswa yang menggunakan model pembelajaran kooperatife tipe Student Teams Achievement Division dengan pembelajaran biasa. Metode ini diterapkan pada mahasiswa Universitas Islam Makassar Tahun ajaran 2019/2020. Kelas VII A sebagai kelas yang tidak diberikan perlakuan menggunakan model pembelajaran kooperatif tipe STAD dan kelas VII B sebagai kelas yang diberi perlakuan model pembelajaran Student Teams Achievement Division STAD. Tahap awal pengumpulan data dilakukan melalui tes, observasi dan dokumentasi. Uji coba instrumen menggunakan uji realibilitas dan validitas. Data analisis yang digunakan adalah uji normalitas dan homogenitas untuk menguji hipotesis digunakan uji t. Hasil penelitian menunjukkan adanya perbedaan hasil yang signifikan antara yang menggunakan metode STAD dengan yang tidak menggunakan metode tersebut. Penelitian menyimpulkan bahwa kreativitas mahasiswa yang menggunakan metode STAD lebih baik dibanding yang tidak menggunakan tipe STAD.
PENERAPAN METODE ELEMEN HINGGA UNTUK DESAIN DAN ANALISIS PEMBEBANAN RANGKA CHASSIS MOBIL MODEL TUBULAR SPACE FRAME
Authors: Abbas Hammada , Juma Djufri , Jahuddin Ma'ruf R 
Published: December 2020

Metode Elemen Hingga (MEH) merupakan salah satu metode yang dapat digunakan untuk mendesain dan menganalisis kekuatan rangka chassis mobil. Penelitian ini bertujuan untuk mendesain rangka serta melakukan assessment pada desain tersebut. Dalam penelitian ini, MEH diterapkan melalui proses komputasi dengan bantuan Autodesk Inventor untuk mendesain rangka dan Autodesk Robot Structural Analysis untuk melakukan assessment. Material pipa logam yang digunakan berspesifikasi Steel AISI 1020 107 HR dan jenis rangka yang dipilih adalah model tubular space frame. Asumsi dimensi rangka mengambil contoh dari desain BMW i3 yang merupakan mobil listrik 4 penumpang. Beban yang diberikan berupa beban statis yang terdiri atas beban penumpang, beban kursi penumpang, beban baterai, dan beban motor listrik. Pada hasil desain, rangka terdiri atas 134 elemen dan 107 node dengan ukuran 2 in. x 0.154 in. pada dasar rangka dan 1.5 in. x 0.145 in. pada keseluruhan sisanya. Perpindahan maksimal terletak pada node 175 dengan nilai 1,3164 mm. Besar dan posisi gaya maksimal untuk tiap sumbu rangka adalah Fx: 1985,126 N (node 225), Fy: 959,480 N (node 14), dan Fz: 935,914 N (node 34). Tegangan maksimal terletak pada node 129 dengan nilai 35,443 MPa. Regangan maksimal terletak pada bar 70 dengan nilai 0,00450474. Dapat disimpulkan bahwa desain rangka mampu menahan beban yang diberikan dan tidak mengalami kerusakan.
Características clínicas, resultados funcionales y oncológicos de los pacientes con tumores renales tratados con nefrectomía parcial
Authors: Herrera Muñoz Javier Antonio , Preciado Estrella Diego Antonio , Villalpando Gómez Luis , Santana Ríos Zael , Martínez Cervera Pedro , Scavuzzo Anna , Jiménez-Ríos Miguel Ángel 
Published: December 2020

Antecedentes: La nefrectomía parcial (NP) se ha convertido en el manejo estándar de los tumores T1 (£ 7cm) y/o en riñón único, tumores bilaterales y cáncer hereditario. En México existen pocos estudios que reporten los resultados de dicho procedimiento.
Objetivo: Conocer las características clínicas, morbilidad perioperatoria y resultados oncológicos y funcionales de la NP en el INCan.
Materiales y métodos: Estudio retrospectivo y analítico de los pacientes de NP del año 2000 al 2018. Se reportaron resultados oncológicos y perioperatorios.
Resultados: Se analizaron 79 pacientes con 82 NP. Edad media 52 años. El T clínico fue T1a y T1b en 62 (74.6%) y 20 (24.4%) casos respectivamente. Se realizó isquemia caliente en 39 (47.6%) y sin isquemia en 35 (42.7%). La media de tiempo quirúrgico, sangrado y estancia hospitalaria fue de 162 min, 449 ml y 2.1 días respectivamente. El abordaje abierto fue en 70 (85.4%) y laparoscópico en 12 (14.6%). Las complicaciones tempranas se presentaron en 17 (20%) incluyendo 9 (11%) transfusiones; 66 (80.5%) procedimientos reportaron células claras. Los márgenes quirúrgicos fueron negativos en 73 (89%). La sobrevida cáncer específica y sobrevida global a los 5 años fue de 100% y 92% respectivamente. La media estimada de tasa de filtración glomerular (TFG) prequirúrgica fue 88ml/min y de 79ml/min al año. La isquemia renal influyó en la disminución de la TFG.
Conclusiones: La CCN en nuestros pacientes muestra resultados similares a lo reportado en otros centros de experiencia internacional por lo que intentar realizarlo en todos los tumores T1 es seguro en nuestra población.
Hematoma renal espontáneo. Reporte de serie de casos
Authors: Garza Montúfar María Esther , Aguirre-Amador Luis Ariel , Galaviz- Hernández Sergio Arturo , Ramírez- Rodríguez Diego Fernando , Sandoval- Valle Miguel Ángel , Castañeda –Solís Carlos Ely 
Published: December 2020

Antecedentes: El Hematoma Renal Espontáneo (hre) es una patología poco común. El diagnóstico adecuado puede evitar complicaciones que ponen en peligro la vida. El objetivo de este estudio es reportar nuestra experiencia en pacientes diagnosticados con hre.
Materiales y métodos: La serie de casos consta de 17 pacientes con hre atendidos en el periodo 2016-2018, se revisaron los expedientes clínicos para recabar su etiología, evolución y tratamiento.
Resultados: 12 (70%) pacientes fueron del sexo femenino y 5 (30%) del sexo masculino, con una media de edad de 53.6 años. A todos los pacientes se les realizó Tomografía Axial de Abdomen como método diagnóstico. Catorce pacientes fueron tratados quirúrgicamente (nefrectomía) y tres se manejaron de manera conservadora. La causa más frecuente fue pielonefritis (35%), seguido de tumor maligno en 18%. Por su parte, 29% de los pacientes fueron catalogados como idiopáticos.
Discusión y conclusiones: En la serie analizada, el hre fue más frecuente en mujeres, la causa predominante fue la pielonefritis, seguido de los tumores malignos. El tratamiento más frecuente fue la nefrectomía. En casos seleccionados, se puede llevar a cabo un manejo conservador.
Complicaciones intraoperatorias y posoperatorias de las cintas medio uretrales libres de tensión en incontinencia urinaria de esfuerzo
Authors: Ayala-Quispe Vianey Brigida , Guerrero-Reyes Guadalupe , Gutiérrez-González Adrián , Hernández-Velázquez Ricardo , Moysen-Marín Claudia Montserrat , Barragán-Ochoa Cristobal 
Published: December 2020

Antecedentes: La colocación de cintas medio uretral son actualmente el tratamiento de primera línea para la incontinencia urinaria de esfuerzo. El objetivo fue evaluar las complicaciones intra y posoperatorias de las cintas transobturadora y retropúbica; y los factores de riesgo asociados.
Material y métodos: Estudio de cohorte retrospectivo en 105 mujeres durante el 2016 a 2018. Se dividió en dos grupos: TVT (n=28) y TOT (n=77). Se analizaron variables demográficas, factores de riesgo, complicaciones intra y posoperatorias. Se realizo estadística descriptiva y correlación de variables con programa SPSS v17.0, y p ≤ 0.05 estadísticamente significativo.
Resultados: La edad promedio fue 56.7 ± 8.8 años; 31.4% (n=33) con incontinencia de esfuerzo, 65.7% (n=69) con incontinencia mixta (IUM) y 2.9% (n=3) con incontinencia oculta. La tasa de complicación global fue de 29.5% (n=31). La complicación intraoperatoria común fue la perforación vesical 3.8% en el grupo TVT asociada a obesidad (OR 12.9). Las complicaciones posoperatorias estuvieron relacionadas con la TOT (p=0.049), compuestas por infección de vías urinarias (11.4%), inguinodinea (7.6%) y otras (6.9%). El riesgo de infección urinaria posoperatorio estuvo asociado con incontinencia de esfuerzo (p=0.03), ausencia de tratamiento de incontinencia urinaria mixta (p=0.04); aumentado la tasa de incontinencia urinaria de urgencia de novo.
Conclusiones: El enfoque transobturador tiene bajos índices de complicaciones transoperatorias en comparación con la retropúbica. La complicación más común en nuestra serie fue la infección urinaria por lo que se requieren estudios prospectivos aleatorizados.
Validitas dan Realibilitas Instrumen Teori Pilihan Karir Holland di Indonesia
Authors: Anggraini Weni , Kurniawan Fandy , Susilawati Susilawati , Hasna Afra 
Published: December 2020

Validity and reliability are the main topics in every research instruments. It is important how to create research instrument that is connected to the construct being measured. In this article, the authors tested the validity and reliability of Holland's career instrument Indonesian version. The participants involved are in the period of career preparation and choice, within an educational institution or a job, but has not yet had satisfaction with their career. The participants' age range from 15 to 27 years. The validity test is carried out using the conventional validity type, where the item is declared valid if the correlation coefficient is ≥ 0.3. The results showed 43 items were declared valid and 5 items were declared invalid while the reliability coefficient found is 0.906. Based on the results, Holland's career instrument Indonesian version in a good instrument to measure career preparation and career choice.