bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and activity of radium-223 in metastatic castration-resistant prostate cancer: the experience of Istituto Nazionale dei Tumori
Authors: Raimondi Alessandra , Sepe Pierangela , Claps Melanie , Maccauro Marco , Aliberti Gianluca , Pagani Filippo , Apollonio Giulia , Randon Giovanni , Peverelli Giorgia , Seregni Ettore , Verzoni Elena , Procopio Giuseppe 
Published: March 2020

Introduction: Therapeutic decision-making in metastatic castration-resistant prostate cancer (mCRPC) represents an open challenge. Radium-223 is approved for patients with symptomatic bone metastases, no visceral involvement, progressing after at least 2 lines of systemic therapy, or ineligible for any other systemic treatment. Methods: We performed a retrospective, observational study on patients with mCRPC treated with radium-223 at our institution outside of clinical trials, to assess the safety and activity in a real-world population. Data regarding baseline patient/disease characteristics and treatment outcomes (number of cycles, treatment-related adverse events [AEs], cause of discontinuation, and best response) were collected. Results: Overall, 41 patients were treated from September 2015 to September 2018. Median age was 73 years; baseline Eastern Cooperative Oncology Group Performance Status (ECOG PS) was 0, 1, or 2 in 15%, 80%, and 5% of cases, respectively; and 3%, 41%, 44%, and 12% of patients had <6, 6–20, >20, and superscan bone lesions, respectively. A median number of 5 cycles (interquartile range 3–6) with median dose 19.52 MBq (interquartile range 12.87–24.83) was received. Treatment schedule was completed in 49% of cases; discontinuations due to AEs, disease-related death, or disease progression occurred in 24%, 33%, and 43% of patients, respectively. Any-grade AEs occurred in 73% and grade 3/4 treatment-related AEs occurred in 29% of patients, mainly anemia, decreased platelet count, and fatigue. No skeletal-related events or treatment-related deaths were recorded. After treatment, 66%, 2%, and 32% of patients had a stable, improved, or deteriorated ECOG PS versus baseline, respectively, and 24%, 61%, and 15% reported a stable, improved, or worsened pain symptom control. Post-treatment versus baseline alkaline phosphatase was reduced or stable in 46% and increased in 54% of patients, whereas prostate-specific antigen was decreased or stable in 83% and increased in 17% of patients. Conclusions: Our study provides clinically useful real-world data on radium-223, highlighting the importance of multidisciplinary patient management to guarantee the best continuum of care for patients with mCRPC.
The Life Experiences Among Primary Family Caregivers of Home-Based Palliative Care
Authors: Wu Meng-Ping , Huang Sheng-Jean , Tsao Lee-Ing 
Published: March 2020

Background: An increasing number of patients with terminal illnesses prefer to die in their own homes due to aging, high medical payments, a limited number of hospitalization days, and the ability to receive care from family members. However, few studies have been conducted on the subjective perception and value of caregivers for home-based palliative care (HBPC). Objective: To identify common themes and topics of primary family caregivers’ lived experiences with HBPC when taking care of terminally ill family members. Methods: We conducted audio-recorded transcripts of one-on-one in-depth interviews of primary family caregivers of HBPC. Through a purposive sampling method, the participants were all interviewed; these interviews were transcribed verbatim and analyzed using a grounded theory approach. Results: A total of 22 primary family caregivers participated in the study. “Wholeheartedly accompanying one’s family to the end of life at home” was the core category. Six main themes describing caregivers’ experiences emerged from the interviews: (1) learning the basic skills of end-of-life home care, (2) arranging the sharing and rotation of care, (3) preparing for upcoming deaths and funerals, (4) negotiating the cultural and ethical issues of end-of-life home care, (5) ensuring a comfortable life with basic life support, and (6) maintaining care characterized by concern, perseverance, and patience. Conclusions: Primary family caregivers of HBPC need support and must learn home care skills by means of the holistic approach. It is crucial to establish assessment tools for caregivers’ preparedness for HBPC, including biopsychosocial and cultural considerations.
Comparison of Suture-Augmented Ligamentplasty to Transarticular Screws in a Lisfranc Cadaveric Model
Authors: Nery Caio , Baumfeld Daniel , Baumfeld Tiago , Prado Marcelo , Giza Eric , Wagner Pablo , Wagner Emilio 
Published: March 2020

Background: Lisfranc injuries represent a spectrum of trauma from high-energy lesions, with significant instability of the midfoot, to low-energy lesions, with subtle subluxations or instability without gross displacement. Recently, treatment options that allow for physiologic fixation of this multiplanar joint are being evaluated. The purpose of this study was to analyze the stability of a cadaveric Lisfranc injury model fixed with a novel suture-augmented neoligamentplasty in comparison with a traditional transarticular screw fixation construct. Methods: Twenty-four fresh-frozen, matched cadaveric leg and foot specimens (12 individuals younger than 65 years of age) were used for this study. Two different types of Lisfranc ligament injuries were tested: partial and complete. Two different methods of fixation were compared: transarticular screws and augmented suture ligamentplasty with FiberTape. Specimens were fixed to a rotation platform in order to stress the joints while applying 400 N of axial load and internal and external rotation. Six distances were measured and compared between the intact, injured, and fixed states with a 3D Digitizer arm, in order to evaluate the stability between them. Analysis of variance was used with P < .05 considered significant. Results: Using distribution graphs and analyzing the grouped data, it was observed that there was no difference between the 2 stabilization methods, but the augmented suture ligamentplasty presented lower variability and observed distance shortenings were more likely to be around the mean. The variability of the stabilization with screws was 2.9 times higher than that with tape ( P < .001). Conclusion: We suggest that augmented suture ligamentplasty can achieve similar stability to classic transarticular screws, with less variability. Clinical Relevance: This cadaveric study adds new information on the debate about Lisfranc lesions treatment. Flexible fixations, such as the synthethic ligamentplasty used, can restore good stability such as conventional transarticular screws.
Cross-sectional evaluation of surface contamination with 9 antineoplastic drugs in 93 Canadian healthcare centers: 2019 results
Authors: Palamini Marie , Gagné Sébastien , Caron Nicolas , Bussières Jean-François 
Published: March 2020

Introduction The primary objective was to describe environmental contamination with National Institute for Occupational Safety and Health Group 1 hazardous drugs in oncology pharmacies and outpatient clinics in Canada in 2019, as part of an annual surveillance project. Methods In each participating center, 12 standardized sites (6 in the oncology pharmacy and 6 in outpatient clinic) were sampled. Each sample was prepared to allow quantification of six antineoplastic drugs (cyclophosphamide, ifosfamide, methotrexate, gemcitabine, 5-fluorouracil, and irinotecan) by ultra-performance liquid chromatography-tandem mass spectrometry. Samples were also tested for three additional antineoplastic drugs (docetaxel, paclitaxel, and vinorelbine) without quantification. The impact of certain characteristics of the sampling sites was evaluated with a Kolmogorov–Smirnov test for independent samples. Results Ninety-three Canadian centers participated in 2019, with a total of 1045 surfaces sampled. Cyclophosphamide was the drug most often found in the surface samples (32.4% of samples with positive result), followed by gemcitabine (20.3%). The front grille inside the biological safety cabinet (81.5% of samples positive for at least one antineoplastic drug) and the armrest of a treatment chair (75.8%) were the most frequently contaminated surfaces. Centers with more oncology inpatient and outpatient beds, those that prepared more antineoplastic drugs each year, and those that used more cyclophosphamide each year had higher concentrations of cyclophosphamide contamination on the surfaces tested ( p <  0.0001). Conclusion Traces of dangerous drugs were found in oncology pharmacies and oncology outpatient clinics in 93 Canadian hospitals in 2019. However, the quantities measured were very small. Every healthcare worker should consider these work areas to be contaminated and should wear appropriate protective equipment.
Prognostic scoring system for metastatic spine tumors derived from hepatocellular carcinoma
Authors: Uei Hiroshi , Tokuhashi Yasuaki 
Published: March 2020

Purpose: The prognosis of hepatocellular carcinoma (HCC) has recently improved, and so clinicians have greater opportunity to treat HCC-derived spinal metastases. Therefore, predicting life expectancy is important for determining the optimal treatment strategy for such tumors. This study aimed to investigate the prognostic factors for HCC-derived metastatic spine tumors and to develop a scoring system for predicting life expectancy in such cases. Methods: The posttreatment survival time and factors that might influence it were investigated in 62 patients with HCC-derived metastatic spine tumors who were treated at our department (surgery: 27 patients and conservative treatment: 35 patients), and a prognostic scoring system for predicting life expectancy was developed by combining the factors that significantly influenced survival. Results: In the univariate analyses, sex, the patient’s general condition, the presence/absence of major internal organ metastasis, the total revised Tokuhashi score, the serum albumin level, Child-Pugh class, spinal surgery, and bone-modifying agent (BMA) treatment were found to influence the posttreatment survival time. These factors were subjected to multivariate analysis, and a novel scoring system for predicting life expectancy based on the patient’s general condition, the serum albumin level (or Child-Pugh class), and BMA treatment was developed. In the retrospective analysis, the concordance rate between the patients’ life expectancy and actual survival times was 90.3%. Conclusion: The patient’s general condition, the serum albumin level (or Child-Pugh class), and BMA treatment influenced the posttreatment survival times of patients with HCC-derived metastatic spine tumors. A prognostic scoring system based on these factors was proposed.
Reliability and Variability Assessment of Femoral Artery Pseudoaneurysm Measurements Between Pre- and Postprocessed B-mode Ultrasound Images
Authors: Kaifi Reham , Almatrafi Mohammed , Alahmary Ferdos , Chen Andrew , Macsata Robyn , Sarani Babak , Zderic Vesna 
Published: March 2020

Objective: To assess the reliability and variability of femoral artery pseudoaneurysm (FAP) measurements between pre- and postprocessed sonograms acquired in a major medical center in Saudi Arabia as compared with results obtained from a major medical center in the United States. Methods: Retrospective image analysis was conducted on 23 FAP sonograms, which were evaluated by four observers. Observers measured FAP sac and neck from pre- and postprocessed images and remeasured again after 2 weeks, to avoid recall bias. Results: The use of image processing was more profound for the novice observers in measuring FAP neck width and length. The intraclass correlation coefficient (ICC) for FAP neck width improved after segmentation from 0.63 to 0.91; in contrast, the ICC improved from 0.91 to 0.97 for experts. The average ICCs for FAP neck length improved from 0.40 to 0.79 for novices and from 0.86 to 0.95 for experts. The largest variation of values, within observers, were for neck length obtained from the original images. The range varied from 0.16 to 0.37 cm and was reduced to 0.10 to 0.18 cm with segmented images. Conclusion: As demonstrated previously, sonographic image processing resulted in increased reliability and decreased variability for FAP measurements.
Redefinition of coquimbite, AlFe3+3(SO4)6(H2O)12⋅6H2O
Authors: Mauro Daniela , Biagioni Cristian , Pasero Marco , Skogby Henrik , Zaccarini Federica 
Published: March 2020

AbstractCoquimbite, AlFe3+3(SO4)6(H2O)12⋅6H2O, was considered as a pure Fe3+hydrated sulfate. However, previous mineralogical studies pointed out the occurrence of essential Al, occupying a distinct site in the crystal structure of this mineral. Through the critical re-examination of the available literature and new crystal-chemical data collected on a specimen from the Monte Arsiccio mine, Apuan Alps, Tuscany, Italy, the chemical formula of coquimbite has been revised, taking into account the occurrence of Al. Coquimbite has a homeotypic relationship with paracoquimbite, Fe4(SO4)6(H2O)12⋅6H2O; both mineral species belong to the coquimbite group. On the contrary, aluminocoquimbite, Al2Fe2(SO4)6(H2O)12⋅6H2O, has a different topology and does not belong to that group.
Successful treatment of thrombocytopenia with daratumumab after allogeneic transplant: a case report and literature review
Authors: Migdady Yazan , Ediriwickrema Asiri , Jackson Ryan Patrick , Kadi Wendy , Gupta Ridhi , Socola Francisco , Arai Sally , Martin Beth A. 
Published: March 2020

Key Points
A source of treatment refractoriness in immune cytopenias appears to be residual CD138/38-positive lymphocyte populations. A short course of daratumumab is a novel treatment of refractory thrombocytopenia after failure of standard treatment options.
Regional distribution of high-attenuation areas on chest computed tomography in the Multi-Ethnic Study of Atherosclerosis
Authors: Choi Bina , Kawut Steven M. , Raghu Ganesh , Hoffman Eric , Tracy Russell , Madahar Purnema , Bernstein Elana J. , Barr R. Graham , Lederer David J. , Podolanczuk Anna 
Published: March 2020

High-attenuation areas (HAA) are a computed tomography-based quantitative measure of subclinical interstitial lung disease (ILD). We aimed to validate HAA in lung regions that are less subject to artefacts, such as extravascular lung water or dependent atelectasis. We examined the associations of HAA within six lung regions (basilar, non-basilar, peel, core, basilar peel, basilar core) with serum biomarkers of lung remodelling, forced vital capacity (FVC), visually-assessed interstitial lung abnormalities (ILA), and all-cause and ILD-specific mortality.We performed cross-sectional and longitudinal analyses of participants in the Multi-Ethnic Study of Atherosclerosis, a prospective cohort of 6814 adults aged 45–84 years without known cardiovascular disease who underwent cardiac computed tomography.Median regional HAA ranged from 3.8% in the peel to 4.8% in the basilar core. Doubling of regional HAA was associated with greater serum matrix metalloproteinase-7 (range 3.8% to 10.3%; p≤0.01), higher odds of ILA (OR 1.42 to 2.20; p≤0.03), and a higher risk of all-cause mortality (hazard ratio 1.20 to 1.47; p≤0.001). Doubling of regional HAA was associated with greater serum interleukin-6 (4.9% to 10.3%; p≤0.005) and higher risk of ILD-specific mortality (hazard ratio 3.30 to 3.98; p<0.001), except in the basilar core. Doubling of regional HAA was associated with lower FVC in the non-basilar, core and basilar core (113 mL to 186 mL; p<0.001).Associations of HAA with lung remodelling biomarkers, ILA risk and all-cause mortality were consistent across all regions of the lung, including dependent areas where atelectasis may be present. These findings support the validity of HAA as a measure of pathologic subclinical ILD.
Mass-Spring-Damping Theory Based Equivalent Mechanical Model for Cylindrical Lithium-ion Batteries under Mechanical Abuse
Authors: Wang Wenwei , Li Yiding , Lin Cheng , Yang Sheng 
Published: March 2020

AbstractAn equivalent mechanical model with the equivalent physical meaning of mass-spring-damping is proposed for cylindrical lithium-ion batteries through experiments and theory. The equivalent mechanical model of a cylindrical lithium-ion battery consists of a spring-damping parallel unit. Therefore, a spring-damping parallel unit connecting a damping unit in series is selected to construct the constitutive characteristics of the battery under mechanical abuse. Comparison results show that the equivalent mechanical model can more effectively describe the mechanical properties of the batteries than most cubic fitting models, of which the average relative error of the equivalent mechanical model under different states-of-charge is less than 6.75%. Combined with the proposed equivalent mechanical model, the failure process of the batteries was simulated and analyzed using LS-Dyna and HyperWorks. Under rigid rod tests, failure occurred at the core and bottom of the batteries; under hemispherical punch tests, failure occurred at the core and top, consistent with the experimental results. The average prediction error for the failure displacement under different abuse conditions is less than 4% in the simulations. The equivalent mechanical model requires only a few parameters and can be recognized easily. In the future, the model can be used in safety warning devices based on mechanical penetration.
Timing of the reproductive cycle of waved whelk, Buccinum undatum, on the U.S. Mid-Atlantic Bight
Authors: Borsetti Sarah , Munroe Daphne , Rudders David , Chang Jui-Han 
Published: March 2020

AbstractDevelopment of the unmanaged waved whelk (Buccinum undatum) fishery on the Mid-Atlantic continental shelf of the United States has initiated investigation into fisheries-related biological and population attributes of the species in this region. Maturation and reproduction timing vary by location for this species and are likely linked to bottom water temperature. This study examined the seasonal fluctuations in relevant body metrics and gonadosomatic index in relation to bottom temperature to assess the timing of the reproductive cycle of the B. undatum population in the southern-most extent of this species’ range in the Atlantic. To characterize variation over the maturation schedule, nine locations in the Mid-Atlantic Bight (MAB) were sampled five times between January 2017 and September 2017. Maturity was assessed macroscopically, with morphological methods, and via gonadosomatic indices. Male behavioral maturity estimates, based on a penis length to shell length index (PL50), were compared to estimates made using other methods for assessing maturity to test the efficacy of this commonly used ratio. Mature whelk were found in all months and peak reproductive activity was observed in spring and early summer. This timing suggests that ideal sampling to visually identify maturity to estimate size of maturity would be late winter or early spring. Unique oceanographic dynamics in the MAB, such as strong seasonal stratification results in large changes in annual bottom temperature which appears to be closely linked to the reproductive cycle in this region. Our data suggest that B. undatum in the MAB experience spawning and development at ~ 7–8 °C; temperatures warmer than Canadian populations and cooler than some UK conspecifics. To our knowledge, this is the first study to document the annual reproductive cycle of waved whelk in the United States.
GenomeQC: a quality assessment tool for genome assemblies and gene structure annotations
Authors: Manchanda Nancy , Portwood John L. , Woodhouse Margaret R. , Seetharam Arun S. , Lawrence-Dill Carolyn J. , Andorf Carson M. , Hufford Matthew B. 
Published: March 2020

Abstract
Background
Genome assemblies are foundational for understanding the biology of a species. They provide a physical framework for mapping additional sequences, thereby enabling characterization of, for example, genomic diversity and differences in gene expression across individuals and tissue types. Quality metrics for genome assemblies gauge both the completeness and contiguity of an assembly and help provide confidence in downstream biological insights. To compare quality across multiple assemblies, a set of common metrics are typically calculated and then compared to one or more gold standard reference genomes. While several tools exist for calculating individual metrics, applications providing comprehensive evaluations of multiple assembly features are, perhaps surprisingly, lacking. Here, we describe a new toolkit that integrates multiple metrics to characterize both assembly and gene annotation quality in a way that enables comparison across multiple assemblies and assembly types.

Results
Our application, named GenomeQC, is an easy-to-use and interactive web framework that integrates various quantitative measures to characterize genome assemblies and annotations. GenomeQC provides researchers with a comprehensive summary of these statistics and allows for benchmarking against gold standard reference assemblies.

Conclusions
The GenomeQC web application is implemented in R/Shiny version 1.5.9 and Python 3.6 and is freely available at https://genomeqc.maizegdb.org/ under the GPL license. All source code and a containerized version of the GenomeQC pipeline is available in the GitHub repository https://github.com/HuffordLab/GenomeQC.
Sirt2-associated transcriptome modifications in cisplatin-induced neuronal injury
Authors: Zhao Xin , Du Wuying , Zhang Manchao , Atiq Zainab O. , Xia Fen 
Published: March 2020

Abstract
Background
Chemotherapy-induced peripheral neuropathy is not only one of the most common causes of dose reduction or discontinuation of cancer treatment, but it can also permanently decrease the quality of life of cancer patients and survivors. Notably, Sirt2 protects many organs from various injuries, including diabetic peripheral neuropathy. As demonstrated previously by our laboratory and others, the overexpression of Sirt2 can improve cisplatin-induced neuropathy, although the mechanism is still unclear.

Results
In this study, the underlying mechanism by which Sirt2 protects neurons from cisplatin-induced injury was explored using the RNAseq technique in cultured rodent neurons. Sirt2 status was modified by genetic knockout (Sirt2/KO) and was then reconstituted in Sirt2/KO cells (Sirt2/Res). We observed 323 upregulated genes and 277 downregulated genes in Sirt2-expressing cells (Sirt2/Res) compared to Sirt2-deficient cells (Sirt2/KO). Pathway analysis suggested that Sirt2 may affect several pathways, such as MAPK, TNF, and cytokine–cytokine interaction. Furthermore, cisplatin-induced changes to the transcriptome are strongly associated with Sirt2 status. Cisplatin induced distinctive transcriptome changes for 227 genes in Sirt2-expressing cells and for 783 genes in Sirt2-deficient cells, while changes in only 138 of these genes were independent of Sirt2 status. Interestingly, changes in the p53 pathway, ECM–receptor interactions, and cytokine–cytokine receptor interactions were induced by cisplatin only in Sirt2-deficient cells.

Conclusions
This study demonstrated that Sirt2 regulates the transcriptome in cultured rodent neuronal cells. Furthermore, Sirt2-associated transcriptome regulation may be an important mechanism underlying the role of Sirt2 in organ protection, such as in cisplatin-induced neuronal injury. Sirt2 may be a potential target for the prevention and treatment of chemotherapy-induced neuropathy.