bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Implant Surface Changes due to instrumentation with different tips for ultrasonic-driven debridement
Authors: Sahrmann Philipp , Winkler Sophie , Gubler Andrea , Attin Thomas 
Published: September 2020

Abstract
Background
To assess the changes of implant surfaces of different roughness after instrumentation with ultrasonic-driven scaler tips of different materials.
Methods
Experiments were performed on two moderately rough surfaces (I – Inicell® and II – SLA®), one surface without pre-treatment (III) and one smooth machined surface (IV). Scaler tips made of steel (A), PEEK (B), titanium (C), carbon (D) and resin (E) were used for instrumentation with a standardized pressure of 100 g for ten seconds and under continuous automatic motion. Each combination of scaler tip and implant surface was performed three times on 8 titanium discs. After instrumentation roughness was assessed by profilometry. Morphological changes were assessed by scanning electron microscopy, and element distribution on the utmost surface by energy dispersive X-ray spectroscopy.
Results
The surface roughness of discs I and II were significantly reduced by instrumentation with all tips except E. For disc III and IV roughness was enhanced by tip A and C and, only for IV, by tip D. Instrumentation with tips B, D and E left extensive residuals on surface I, II and III. The element analysis of these deposits proved consistent with the elemental composition of the respective tip materials.
Conclusion
Instrumentation by ultrasonic-driven tips changes implant surfaces of different roughness significantly. The least change of implant surfaces might result from resin or carbon tips on machined surfaces.
Prognostic Value of Non-alcoholic Fatty Liver Disease in Predicting Cardiovascular Events in Diabetes Mellitus Patients: A Prospective Cohort Study
Authors: Ichikawa Keishi , Miyoshi Toru , Osawa Kazuhiro , Miki Takashi , Toda Hironobu , Ejiri Kentaro , Yoshida Masashi , Nakamura Kazufumi , Morita Hiroshi , Ito Hiroshi 
Published: September 2020

Abstract
Background: Risk stratification of cardiovascular events in patients with type 2 diabetes mellitus (T2DM) has not been established. coronary artery calcium score (CACS) and non-alcoholic fatty liver disease (NAFLD) are independently associated with cardiovascular events in T2DM patients. This study examined the incremental prognostic value of NAFLD assessed by non-enhanced computed tomography (CT) in addition to CACS and Framingham risk score (FRS) on cardiovascular events in T2DM patients.Methods: This prospective pilot study included 529 T2DM outpatients without history of cardiovascular disease who underwent CACS measurement due to suspected coronary artery disease. NAFLD was defined on CT images as a hepatic: spleen attenuation ratio <1.0. cardiovascular events were defined as cardiovascular death, nonfatal myocardial infarction, late coronary revascularization, nonfatal stroke, or hospitalization for heart failure.Results: Of 529 patients (61% men, mean age 65 years), NAFLD was identified in 143 (27%). During the median 4.4 years of follow-up, 44 cardiovascular events were documented. In multivariate Cox regression analysis, the presence of NAFLD, CACS and FRS were associated with cardiovascular events with hazard ratios of 5.45 (95% confidential interval [CI]: 2.84–10.45; p<0.001), 1.56 (95% CI: 1.32–1.85; p<0.001), and 1.23 (95% CI: 1.08–1.39; p=0.001), respectively. The global chi-square score for predicting cardiovascular events significantly increased from 27.0 to 49.7 by adding NAFLD to CACS and FRS (p<0.001). The addition of NAFLD to a model including CACS and FRS significantly increased the C-statistic from 0.71 to 0.80 (p=0.005). The net reclassification achieved by adding CACS and FRS was 0.551 (p<0.001). Conclusions: NAFLD assessed by CT, in addition to CACS and FRS, could be useful in assessing T2DM patients at higher risk of cardiovascular events.
In-Hospital Mortality After Blood Purification With and Without Acrylonitrile-Co-Methallyl Sulfonate Surface-Treated Membrane for Pneumonia-Associated Sepsis: A Retrospective Cohort Study
Authors: Hayashi Kentaro , Sasabuchi Yusuke , Matsui Hiroki , Nakajima Mikio , Ohbe Hiroyuki , Fushimi Kiyohide , Ono Kazuyuki , Yasunaga Hideo 
Published: September 2020

Abstract
Background: Cytokine removal therapy is one of the available therapies for sepsis. Acrylonitrile-co-methallyl sulfonate surface-treated (AN69ST, sepXiris®) membrane has cytokine adsorption capacity and has been widely used for treating sepsis in Japan. The aim of this study was to compare the effects of continuous renal replacement therapy (CRRT) with AN69ST membrane and conventional CRRT for patients with pneumonia-associated sepsis.Methods: We conducted a retrospective cohort study using the Diagnosis Procedure Combination database, a nationwide inpatient database in Japan. We identified adult patients who were hospitalized due to pneumonia and received CRRT within 2 days of admission from September 2014 to March 2017. We included patients who received CRRT with AN69ST membrane within 2 days of admission in the treatment group (AN69ST group); those who received CRRT with other membranes within 2 days of admission were included in the control group (non-AN69ST group). Propensity score matching was used to compare in-hospital mortality between the two groups.Results: Eligible patients (n=2,393) were categorized into the AN69ST group (n=631) or the non-AN69ST group (n=1,762). The overall in-hospital mortality rate in pneumonia patients treated with CRRT was 38.9%. Propensity score matching created a matched cohort of 545 pairs of patients. The in-hospital mortality rate was significantly lower in the AN69ST group than in the non-AN69ST group (35.8 vs. 41.8%, p=0.046).Conclusion: Our data suggest that CRRT with the AN69ST membrane was associated with a significantly lower in-hospital mortality than CRRT with standard membranes among patients with pneumonia-associated sepsis.
Psychometric Properties of the “Lasher and Faulkender Anxiety about Aging Scale” among Iranian older people
Authors: Pakpour Amir , Namjoo Shamsedin , Sabahiazar Khadijeh , Jafarabadi Mohammad Asghari , Chattu Vijay Kumar r , Allahverdipour Hamid 
Published: September 2020

Abstract
BackgroundAssessing anxiety in the elderly and the factors affecting this phenomenon will help the health care providers to provide appropriate and effective support and health care services for older adults. The aim of the present study was to assess the psychometric properties of the Aging Scale (AAS) among Persian speaking older adults.Method:A sample of 703 community-dwelling older adults was recruited for the study. A 'forward-backward' translation procedure was conducted to develop the Iranian version of the AAS. Confirmatory factor analysis (CFA) and Rasch model were then used for construct validity, and GHQ-12 and MSPSS were utilized for assessing concurrent validity of the AAS.ResultThe study participants included 416 (59.2%) men and 287 (40.8%) women with an average age of 69.4 years (SD D 8.11). Cronbach’s alpha for Fear of Old People, Psychological Concerns, Physical Appearance, Fear of Losses and the overall score was 0.881, 0.705, 0.748, 0.768 and 0.77, respectively. Applying CFA, it was found that the four original factors model was the best solution with 0.55 of the total variance. The result of the CFA indicated that this four-factor model had a good fit to the data. The results were then confirmed by Rasch analysis. Moreover, the AAS was significantly correlated with MSPSS (r=-0.395, p < 0.001) and GHQ_12 (r = 0.238, p < 0.001).ConclusionThe Persian version of the AAS was found to be valid and reliable for measuring anxiety of ageing among Persian speaking elderly populations.
Multi-Biomarker Panel Prediction Model for Diagnosis of Pancreatic Cancer: a retrospective and multi-center cohort study
Authors: Lee Doo-Ho , Yoon Woongchang , Lee Areum , Han Youngmin , Byun Yoonhyeong , Kang Jae Seung , Kim Hongbeom , Kwon Wooil , Suh Young-Ah , Choi Yonghwan , Namkung Junghyun , Han Sangjo , Yi Sung Gon , Heo Jin Seok , Han In Woong , Park Joon Oh , Park Joo Kyung , Kim Song Cheol , Jun Eunsung , Kang Chang Moo , Lee Woo Jin , Lee Hyeon Kook , Lee Huisong , Lee Seungyeoun , Jeong Seung-Yong , Lee Kyu Eun , Han Wonshik , Park Taesung , Jang Jin-Young 
Published: September 2020

Abstract
Background

Early diagnosis is paramount in increasing the survival rate of pancreatic ductal adenocarcinoma (PDAC). However, effective early diagnostic tools are lacking at present. The current study aimed to develop a prediction model using a multi-marker panel (LRG1, TTR, and CA19-9) as a diagnostic screening tool for PDAC.
Methods

A large multi-center cohort of 1,991 samples were collected from January 2011 to September 2019, of which 609 are normal (NL), 145 are other cancer (OC; colorectal, thyroid, and breast cancer), 314 are pancreatic benign disease (PB), and 923 are PDAC. The automated multi-biomarker Enzyme-Linked Immunosorbent Assay kit was developed using three potential biomarkers, LRG1, TTR, and CA 19 − 9. Using a logistic regression (LR) model trained on training data set, the predicted values for PDACs were obtained, and the result was classified into one of the three risk groups: low, intermediate, and high. The five covariates used to create the model were sex, age, and biomarkers TTR, CA 19 − 9, and LRG1.
Results

Participants were categorized into four groups as NL (n = 609, 30.6%), OC (n = 145, 7.3%), PB (n = 314, 15.7%), and PDAC (n = 923, 46.4%). The NL, OC, and PB groups were clubbed into the non-PDAC group (n = 1068, 53.6%). The positive and negative predictive value, sensitivity, and specificity were 94.12, 90.40, 93.81, and 90.86, respectively.
Conclusions

This study demonstrates a significant diagnostic performance of the multi-marker panel in distinguishing PDAC from normal and benign pancreatic disease states, as well as patients with other cancers. The study indicates that the introduced multi-marker panel prediction model for PDAC diagnosis can help guide medical decisions for patients, including patients with early stage PDAC or with normal levels of CA 19 − 9.
The Risk of Bias in Iranian Randomized Controlled Trials Included in Cochrane Reviews
Authors: Kabir Ali , Sofi-Mahmudi Ahmad , Behnagh Arman Karimi , Eidkhani Vahid , Baradaran Hamid Reza , Kabiri Payam , Haghdoost Ali Akbar , Mesgarpour Bita 
Published: September 2020

Abstract
Background: Among interventional studies, randomized controlled trials (RCTs) provide the most conclusive evidence. However, RCTs can be susceptible to the risk of bias (RoB). Systematic reviews can be performed to appraise the RoB in the included articles using evaluative tools. This study aimed to describe the main characteristics and focus on the ROB of RCTs conducted in Iran and included in Cochrane Reviews (CRs).Methods: We searched "Iran" by selecting the "Search All Text" and "Review" fields in the Cochrane Database of Systematic Reviews within Ovid. CRs that included the RCTs conducted in Iran were retrieved. A trial was selected only if it was included in CRs, described as a controlled clinical trial, involved human subjects and its RoB was assessed by CR authors. The trials were characterized by investigating the relevant articles and the table "Characteristics of included studies" in each CR. The RoB was investigated by collecting the judgments of the review authors made based on tables of RoB assessment in the CRs.Results: Out of 1166 Iranian RCTs included by 571 CRs, a low RoB was found in 44.9% for random sequence generation, 20.8% for allocation concealment, 32.3% for blinding of participants/personnel, 36.5% for blinding of outcome assessors, 56.3% for incomplete outcome data, 41.3% for selective outcome reporting and 53.8% for other sources of bias.Conclusion: The RoB in Iranian RCTs was found to be mostly high or unclear. It is therefore recommended that the methodological quality of RCTs be seriously addressed in Iran.
Maternal mortality rate in Bao'an district, Shenzhen, China, 1999-2018
Authors: zhu yuanfang , Luo Yali , Wang Wei , Wang Liling , Cheng Yuli , Li Jianmei , Chen Xu 
Published: September 2020

Abstract
Background

China had achieved impressive success in reducing maternal mortality rate (MMR), while substantial heterogeneity still existed, and reports from Shenzhen region remained a blank. This study aiming to use all available data sources to evaluate the MMR from 1999 to 2018 in Bao’an district, Shenzhen, China.
Methods

Data on maternal deaths and key health-service-related indicators were obtained from registration forms and Shenzhen Maternal and Child Health Management System. The levels and trends of MMR, profiles and leading causes of death, as well as results from the maternal mortality review committee were analyzed.
Results

The MMR in Bao’an district declined from 95.31 per 100,000 live births in 1999 to zero in 2018, with an annualized rate of decline of 12.03% per year. A significant declining trend of MMR was observed over 5-year intervals (from 82.61 to 5.22 per 100,000 live births). MMR was higher among migrant population, women aged ≥ 35 years or those who given birth outside the hospital. The first three causes of maternal death included hemorrhage (27.69%), amniotic fluid embolism (22.31%) and internal medical disease complications (15.38%). Nearly ninety percent (86.78%) of maternal deaths were determined to be preventable.
Conclusions

Bao’an district had experienced a fast decline in MMR for a two-decade period, its experience in lowering MMR could provide a guideline for other regions to focus on those who needed particular attention and take targeted interventions to reduce maternal deaths.
Comparison of various behavioral intervention approaches for tobacco cessation- A protocol for a systematic review and network meta-analysis
Authors: Dhawan Priyanka , Goel Sonu , Aggarwal Ashutosh , Ghosh Abhishek , Vijayvergiya Rajesh , Khurana Dheeraj , Verma Roshan , Medhi Bikash 
Published: September 2020

Abstract
Background﻿Despite substantial progress in tobacco control in the last two decades, there is limited literature on the most effective tobacco cessation behavioral intervention. This network meta-analysis will compare various behavior change intervention for tobacco cessation and attempt to rank them to identify the best approach for cessation.MethodologyThe network meta-analysis will include randomized controlled trials on behavior change for tobacco cessation. The PICOS framework will be used while selecting the studies from various established scientific databases viz. Pubmed, Scopus, Embase, and other sources including Clinicaltrial.gov. The primary outcome for this review will be sustained or point prevalence tobacco abstinence at 6 months or 12 months. To graphically depict and document the studies Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines along with PRISMA Network Meta-Analysis extension statement will be used.ConclusionThe network meta-analysis will provide the rankings of behavior change interventions thus determining the most and least effective modality for tobacco cessation. The information obtained will be an important guide for policymakers, implementors, and researchers to choose the priority cessation intervention.RegistrationProtocol of this review and network meta-analysis was registered in PROSPERO: International prospective register of systematic reviews (registration number: CRD42020145768).
Long non-coding RNA LINC00152 regulates cell proliferation and migration by epigenetically repressing LRIG1 expression in cholangiocarcinoma
Authors: Wang Ni , Yu Yang , Xu Boming , Zhang Chunmei , Liu Jie , Dong Liyang , He Xuezhi , Miao Lin , Li Quanpeng 
Published: September 2020

Abstract
Background: Recently, long non-coding RNAs (lncRNAs) have been verified to have significant regulatory roles in multiple human cancer processes. Long non-coding RNA LINC00152, located on chromosome 2p11.2, was identified as an oncogenic lncRNA in various cancers. However, the biological function and molecular mechanism of LINC00152 in cholangiocarcinoma (CCA) are still unknown.Methods: Bioinformatic analysis was performed to determine LINC00152 expression levels in the CCA and normal tissues by using raw microarray data downloaded from Gene Expression Omnibus (GSE76297) and The Cancer Genome Atlas (TCGA). Quantitative reverse transcription PCR (qRT-PCR) was used to validate LINC00152 expression in the CCA tissues compared with that in the paired normal tissues. CCK8, colony formation, Edu assays, transwell assays, flow cytometry, and in vivo tumor formation assays were performed to investigate the biological function of LINC00152 on CCA cell phenotypes. RNA-seq was carried out to identify the downstream target gene which was further examined by qRT-PCR, western bolt and rescue experiments. RNA immunoprecipitation (RIP) and Chromatin immunoprecipitation (ChIP) assays were performed to reveal the factors involved in the mechanism of LINC00152 functions in CCA.Results: LINC00152 is significantly upregulated in cholangiocarcinoma. LINC00152 regulated the proliferation and migration of cholangiocarcinoma cells both in vitro and in vivo. RNA-seq revealed that LINC00152 knockdown preferentially affected genes linked with cell proliferation, cell differentiation and cell adhesion. Furthermore, mechanistic investigation validated that LINC00152 could bind EZH2 and modulate the histone methylation of promoter of leucine rich repeats and immunoglobulin like domains 1 (LRIG1), thereby affecting cholangiocarcinoma cells growth and migration.Conclusion: Taken together, these results demonstrated the significant roles of LINC00152 in cholangiocarcinoma and suggested a new diagnostic and therapeutic direction of cholangiocarcinoma.
Clinical and Para Clinical Findings in Children with Progressive Familial Intrahepatic Cholestasis in Iran; A Referral Center Report
Authors: Zarenezhad Mohammad , Dehghani Seyed Mohsen , Ejtehadi Fardad , Fattahi Mohammad Reza , Kaboodkhani Reza , Tabei Seyyed Mohammad Bagher , Doroudchi Alireza , Forouzesh Mehdi 
Published: September 2020

Abstract
BackgroundProgressive Familial Intrahepatic Cholestasis (PFIC) is a heterogeneous group of disorders with various clinical and para-clinical manifestations. We report clinical and para-clinical findings in children with progressive familial intrahepatic cholestasis in Southern Iran.MethodsMedical records of 102 patients aged ≤18 years old diagnosed with PFIC who referred to our referral center were evaluated from 2008 to 2012. Baseline and clinical characteristics, outcomes and survival of these patients were recorded. ResultsThe study included 61 boys and 41 girls. Most common complaints were jaundice in 53 (51.96 %), pruritus and jaundice in 15 (14.70 %) and jaundice+elevated liver enzymes in 11 (10.78%) children. Main clinical findings in children were jaundice (51.96%), ascites (28.43%), pruritus (19.60%), fever (16.66%) and encephalopathy (14.70%). Inhomogeneous echogenicity (31.37%), splenomegaly (26.47%), hepatomegaly (17.64%), cirrhosis (9.80%) and ascites (6.86%) were the most common sonography findings among children with PFIC, respectively. Histopathologic evaluation showed cirrhosis (34.31%), followed by fibrosis (18.62%), cholestasis (10.78%), inflammation of liver tissue (4.90%), nodule formation (2.94%), and destruction of lobular and vascular architecture (1.96%). Liver transplantation, medical therapy and biliary diversion had been performed for 67%, 13% and 11% of the patients, respectively. Mean (SD) PELD and MELD scores among children with PFIC were 7.14±14.63 and 15.75±7.21, respectively. Three month mortality rate for PFIC patients with end stage liver disease was 13.1%.ConclusionInhere we reported invaluable clinicopathological findings among a large series of patients with PFIC.
Design and Validation of a Questionnaire to Measure the Acceptance of Telemedicine by Healthcare Professionals in Germany
Authors: Verfürth Martina 
Published: September 2020

Abstract
Background: Telemedicine allows healthcare professionals to manage patient treatments remotely and to benefit from the interaction of telemedicine centers. Even though telemedicine responds to the current burdens in healthcare systems, these complex infrastructures depend on technology, financing, organization, policy, legislation, and, not least, on their corresponding acceptance by the user. Little is known in this context about the drivers for this acceptance by healthcare professionals giving treatment. Germany, with the highest healthcare spending in the world, is particularly lagging here. As there is less focus on guidance for building acceptance constructs, and, in particular, little research on the acceptance of interactive telemedicine by healthcare professionals in Germany, the objective was the collection of the relevant factors influencing German healthcare professionals in the implementation of telemedicine service programs (TSSs). Acceptance constructs were built and operationalized in a questionnaire, taking into consideration the gold standard technology acceptance model of Davis.Methods: A literature review was conducted to identify the acceptance factors that had already been detected and frequently confirmed. These factors were evaluated according to the coverage of the interactive infrastructures with telemedicine centers and how accurately they fitted Germany. The identified factors were adapted, and missing factors were designed, via an idea collection for items. The reliability of the developed constructs was tested using a field test to check the constructs using item revision analysis.Results: Frequently supported external variables, taken from 17 filtered studies covering the technical, organizational, social, legal, and individual context, were identified. However, the review showed that there was less focus on the German setting and the interactive aspect, so the market-related variables were adapted and new constructs of “trust in the telemedicine center” and “relationship to patient” were added. Ten variables were proven to have a reliability, measured with Cronbach’s Alpha, of more than 0.7.Conclusion: This paper enhances the already existing technology acceptance studies in healthcare by covering German specifications and the interactive character of TSSs. A corresponding questionnaire has been developed ready for future research.