bluuebunny/crossref_metadata_2025_split huggingface dataset:
High Ki67 proliferation index but not cell-of-origin subtypes is associated with shorter overall survival in diffuse large B-cell lymphoma
Authors: Zaiem Feras , Jerbi Rada , Albanyan Omar , Puccio Jordyn , Kafri Zyad , Yang Jay , Gabali Ali M 
Published: August 2020

Abstract
Background: CD10, BCL6, and MUM1 are commonly used immunohistochemical stains for classifying diffuse large B-cell lymphoma (DLBCL), which is useful in predicting outcome. Conflicting reports of the prognostic value of other markers such as BCL2, CD23, and Ki67 proliferation index have been reported. Our objective was to correlate these immunostains and Hans classification with response to therapy and overall survival. Materials and Methods: A retrospective study of patients diagnosed with DLBCL from 2008–2014 at a tertiary-care cancer hospital. The slides with the IHC stains were reviewed by two independent pathologists. The clinical outcomes––assessed independently––were response to therapy and overall survival. The treatment response evaluation was based on the new Lugano classification. Statistical analyses were conducted using the Fisher’s exact test and Kaplan–Meier survival curves. Significance was set at P < 0.05. Results: Forty-one patients were included in the study with a known Hans classification, available clinical data, and at least 5-year follow-up. CD10 immunostain was reported in all patients, whereas CD23 was the least reported in only four patients. No significant association was observed between CD10, BCL6, MUM1, BCL2, and both Response to therapy and overall survival. Owing to few cases reported CD23 immunostain, further analysis of association is not reported. High Ki67 proliferative index of >80% was statistically significantly associated with shorter overall survival and not statistically significant associated with no response to therapy. Hans classification subtypes were not predictive in regard to therapy response. Conclusion: High Ki67 expression (>80%) was associated with shorter overall survival in DLBCL. Hans classification subtypes were not predictive.
Genetic Resources – A new attempt at serving the community
Authors: Maggioni Lorenzo , Bozzano Michele , Danchin Coralie , Goritschnig Sandra 
Published: August 2020

Through the Horizon 2020 project ’GenRes Bridge’ the new journal Genetic Resources was conceived to serve as a new cross-cutting platform for stakeholders and practitioners in genetic resources. Its ambition is to provide access to relevant information and tools for the monitoring, conservation, management, characterization and use of genetic resources, and thus to contribute to the FAO global plans of action on genetic resources. Conceived to ﬁll the gaps left by the discontinuation of the journals Plant Genetic Resources Newsletter and Animal Genetic Resources, it aims at serving the genetic resources community worldwide and across sectors.
CT-Scan vs MRI in Diagnosing Laryngeal Carcinoma
Authors: Mohammed Nizamuddin  , Mohammed Naseeruddin  , Abkari Anand 
Published: August 2020

Background: MRI imaging offers more sensitivity than CT to cartilage invasion but results in a high rate of false-positive studies which decreases their overall accuracy. The objective is to compare accuracy of CT scan vs MRI in the laryngeal carcinoma. Subjects and Methods: All patients have been diagnosed, with and without contrast, including neck MRI and CT. In order to prevent invalidation, before laryngeal biopsy, MRI and CT scanning have been done such that the images are not altered by peri tumorous inflammation. Results: The MRI classification was right for 20 out of 25 patients (80 percent) and 5 outsized cases: three cT1b lesions were pT1a and two cT1a lesions were squamous cell papilloma’s during pathological examination. CT was accurately identified in 17 out of 25 patients (68%), with 8 understated cases: 3 cT1a lesions by CT were pT1b, 3 cT1a lesions were pT3, and 2 tumours had not been found in the CT scan. Conclusion: Our research showed that MRI in preoperative stage early glottic cancer is more sensitive than CT to accurately select eligible patients for conservatory larynx surgery like super cricoid laryngectomy and cordectomy.
Radioimaging Evaluation of Primary Bone Tumors and Tumor like Lesions
Authors: Sunil K Vatukiya  , Kapadia Bhautik 
Published: August 2020

Background: Bone tumour is relatively rarely encountered by radiologist, so sometimes it creates diagnostic difficulty. Aim over study was to determine the X-ray CT and MRI characteristics of different primary bone tumours and tumour like lesion and correlation of radiologic diagnosis with histopathologic diagnosis whenever possible. To understand the advantages and limitations of different radio-imaging techniques. Subjects and Methods: We have studied total 45 cases of primary bone tumour and tumour like lesions during study of 15 months duration in department of Radiodiagnosis, Baroda Medical College, Vadodara, Gujarat, India. First radiological diagnosis and differential diagnosis was given than histopathologic examination was done in all malignant and indeterminate lesions for final diagnosis. Results: Out of 45 patients 21 (46.6%) were female and 24 (53.3%) were male. Benign and malignant lesions were 69% and 31% respectively. Multiple lesions were common with osteochondroma, hemangioma and multiple myeloma. Most common malignant tumour was osteosarcoma and benign tumour was osteochondroma. Pathologic fracture was seen in 6 patients but out of them 2 fractures were missed on radiograph. Skip lesions were seen in two malignant lesions which was missed on radiograph and CT but it was easily detected on MRI. Conclusion: Radiography is baseline investigation for evaluation of bone tumor and tumour like lesions. Pathological fracture and matrix mineralization can be better seen on CT. MR is superior in detection skip lesion, soft tissue and marrow extension.
Role of Ultrasonography in Thyroid Nodules with Pathological Correlation
Authors: Subhash C. Sylonia  , Kumar Pranay 
Published: August 2020

Background: Thyroid nodule imaging had been a challenging task. Ultrasound has been the modality of choice for detection & evaluation of these lesions. This study was done to identify the accuracy of various imaging features in thyroid nodules that are associated with benignity and malignancy and the overall accuracy of ultrasound in determining malignant nodules. The objective of the study are: (1) Ultrasonographic evaluation of thyroid to characterize the thyroid disease and nodules (benign vs malignant) and their morphologic evaluation. (2) Sensitivity and Specificity on the basis of radiological, and cytopathological correlation for suspected thyroid lesions. Subjects and Methods: A total of seventy patients (70) of both sexes and different age group, meeting the inclusion criterion, were the part of present prospective study. The cases referred to the Department of Radio-diagnosis and imaging from OPD/IPD of Saraswathi Institute of Medical sciences, Hapur from October’2017 to July’2019. An informed consent was taken from all the patients subjected for evaluation. Results: The collective data was analysed for Ultrasound findings of thyroid nodule which presented clinically as solitary or multiple thyroid nodules. The total number of cases analysed was 70 out of which 48 were found to have solitary/multinodular lesions clincally. On ultrasound evaluation out of 48 patients 38 had solitary/multinodular lesions. Conclusion: High resolution sonography is recommended as the primary imaging modality in evaluation of thyroid diseases. It has a high sensitivity and specificity in the diagnosis of thyroid diseases.
Lung Manifestation of Collagen Vascular Disease in HRCT
Authors: Jagruti Kalola  , Trivedi Anjana , Happani Hiral , Chauhan Mohit 
Published: August 2020

Background: The aim of this paper was to evaluate the thoracic manifestations associated with the Connective tissue disorders, with an emphasis on interstitial and airway disease pattern on the High Resolution computed tomography (HRCT) findings. Subjects and Methods: The present study was conducted for a period of one year. A total of 50 patients with various connective tissue disorders having respiratory complaints were evaluated. Results: During the study period 50 patients (80%females and 20%males) underwent evaluation. Cough and dyspnea were the most common presenting symptoms. Variety of thoracic abnormalities weredetected in 67 (95%) cases. Most common abnormality detected on HRCT was interstitial fibrosis/interstitial lung disease present in (60%) cases. Most common parenchymal abnormalities seen were reticulations (61.4%), ground glass opacification (40%), mosaic attenuation (32.8%) and honeycombing (24.3%). Airway abnormalities seen were bronchiectasis (48.5%), emphysema (12.8%), and ground glass nodules (2.8%). Conclusion: Interstitial lung disease is the most common pulmonary manifestation among patients with connective tissue disorders, and early detection and prompt treatment is expected to improve the outcome.
Comparison between Conventional Radiography and High Resolution Computed Tomography in Interstitial Disease of Lungs
Authors: P. Madhu  , D. Santhosh  
Published: August 2020

Background : Interstitial lung diseases are a diverse group of over 200 disease entities in which the primary site of injury is the lung interstitium. These diseases vary widely in their etiology, clinicoradiologic presentation, histopathological features and clinical course. HRCT has its limitations in the detection of interstitial lung diseases, its sensitivity is not 100% and the limitations of sensitivity are not well established. This study attempted to compare between conventional radiography and HRCT in the diagnosis of interstitial lung diseases. Subjects and Methods: All the patients were subjected to both conventional radiography and HRCT examinations and the images were viewed and analyzed. The two modalities were compared with regards to their ability to detect findings like nodular opacities, reticular opacities, septal thickening, honeycombing, lymphadenopathy etc. Results: The study has gender distribution of 60% males and 40% females. The main result of the study was that higher number of samples with findings were detected by HRCT than conventional radiography. In the detection of nodular opacity and septal thickening, the p value was less than 0.05 meaning the difference was statistically significant. Of the 30 patients, 2 had normal chest radiograms while HRCT was able to detect reticular opacities in these patients. The most common abnormality seen in both chest radiograms and HRCT was reticular opacities. The distinction between air space nodules and interstitial nodules was also much better appreciated on HRCT than on conventional radiography. In the detection of honeycombing, HRCT was much more specific being able to detect it in cases when the chest radiogram showed only reticular opacities. Even in the detection of other findings like air trapping and lymphadenopathy, HRCT scored over conventional radiography. Conclusion: HRCT therefore seems to be the investigation of choice in evaluating patients of interstitial lung disease.
Online Life Writing
Authors: Schultermandl Silvia 
Published: August 2020

In lieu of an abstract, here is the first paragraph of this contribution to this forum:
The advent of Facebook in 2004, Twitter in 2006, Tumblr in 2007, Instagram and Pinterest in 2010, and Snapchat and Google+ in 2011 facilitated the emergence of “everyday” autobiographies out of keeping with memoir practices of the past.[1] These “quick media” enable constant, instantaneous, and seemingly organic expressions of everyday lives.[2] To read quick media as “autobiographical acts” allows us to analyze how people mobilize online media as representations of their lives and the lives of others.[3] They do so through a wide range of topics including YouTube testimonials posted by asylum seekers (Whitlock 2015) and the life-style oriented content on Pinterest.[4] To be sure, the political content of these different quick media life writing varies greatly. Nevertheless, in line with the feminist credo that the personal is political, these expressions of selfhood are indicative of specific societal and political contexts and thus contribute to the memoir boom long noticed on the literary market.[5]
Efeitos imediatos da terapia combinada com ultrassom não-focalizado e estimulação elétrica no tratamento de gordura localizada
Authors: Lima Moreira Ana Betina , Bitencourt Shanna , Fioravante Tassinary João Alberto 
Published: August 2020

Introdução: Atualmente, existem diferentes tratamentos não-invasivos sendo utilizados para melhorar o contorno corporal, incluindo o uso de ultrassom (US). A terapia combinada é uma técnica que utiliza uma plataforma composta por US não-focalizado e correntes excitomotoras, que apresenta bons resultados para a redução de gordura localizada.
Objetivos: Verificar os efeitos imediatos de uma sessão única de terapia combinada com US não-focalizado no modo contínuo e corrente elétrica alternada na melhora do contorno corporal.
Métodos: Trinta e seis voluntárias entre 18 e 50 anos participaram do estudo. As participantes foram divididas em dois grupos, Controle (sem tratamento) e Tratado. Análises bioquímicas (perfil lipídico), perimetria e adipometria foram realizadas antes e após o tratamento.
Resultados: A terapia combinada com US e corrente alternada mostrou uma redução significativa nas medidas de perimetria e adipometria da região abdominal das voluntárias do grupo Tratado em comparação com o grupo Controle. Entretanto, o perfil lipídico das participantes dos dois grupos permaneceu inalterado após a sessão de terapia combinada.
Conclusões: O presente estudo mostrou que a terapia combinada com US não-focalizado em modo contínuo e corrente elétrica apresenta redução imediata da gordura localizada abdominal.
Establishment of AIRS climate-level radiometric stability using radiance anomaly retrievals of minor gases and sea surface temperature
Authors: Strow L. Larrabee , DeSouza-Machado Sergio 
Published: August 2020

Abstract. Temperature, H2O, and O3 profiles, as well as CO2, N2O, CH4, chlorofluorocarbon-12 (CFC-12), and sea surface temperature (SST) scalar anomalies are computed using a clear subset of AIRS observations over ocean for the first 16 years of NASA's Earth-Observing Satellite (EOS) Aqua Atmospheric Infrared Sounder (AIRS) operation. The AIRS Level-1c radiances are averaged over 16 d and 40 equal-area zonal bins and then converted to brightness temperature anomalies. Geophysical anomalies are retrieved from the brightness temperature anomalies using a relatively standard optimal estimation approach. The CO2, N2O, CH4, and CFC-12 anomalies are derived by applying a vertically uniform multiplicative shift to each gas in order to obtain an estimate for the gas mixing ratio. The minor-gas anomalies are compared to the National Oceanic and Atmospheric Administration (NOAA) Earth System Research Laboratory (ESRL) in situ values and used to estimate the radiometric stability of the AIRS radiances. Similarly, the retrieved SST anomalies are compared to the SST values used in the ERA-Interim reanalysis and to NOAA's Optimum Interpolation SST (OISST) product. These intercomparisons strongly suggest that many AIRS channels are stable to better than 0.02 to 0.03 K per decade, well below climate trend levels, indicating that the AIRS blackbody is not drifting. However, detailed examination of the anomaly retrieval residuals (observed – computed) shows various small unphysical shifts that correspond to AIRS hardware events (shutdowns, etc.). Some examples are given highlighting how the AIRS radiance stability could be improved, especially for channels sensitive to N2O and CH4. The AIRS shortwave channels exhibit larger drifts that make them unsuitable for climate trending, and they are avoided in this work. The AIRS Level 2 surface temperature retrievals only use shortwave channels. We summarize how these shortwave drifts impacts recently published comparisons of AIRS surface temperature trends to other surface climatologies.
Acute Liver Failure in Patients with Classic Heat Stroke
Authors: Hernández-Ríos Jeremy J. , Martínez-González Fátima María , Gutiérrez-Bañales Luz A. , Beltrán-López J. Andrés , Jaramillo-Ramírez Hiram J. 
Published: August 2020

Background: Classic heat stroke is defined by a core temperature greater than 40° C, severe dehydration and neurological alterations. Patients with liver disease due to heat stroke have been described, mostly by exercise. Hepatic failure is defined as the presence of a coagulopathy accompanied by any degree of hepatic encephalopathy. The primary objective of the study lies in the fact that patients who developed acute liver failure during their hospital stay had a higher risk of mortality.
Methods: A retrospective, analytical study of patients admitted to the General Hospital of Mexicali who suffered from classic heat stroke from March 2006 through August 2010, and a second period from June 2018 to August 2019.
Results: Fifty patients were recruited, the group included 48 (96%) male, with a total of 10 fatalities, representing 20%. INR greater than 1.5, AST and ALT levels were not related to an increased mortality rate.
Conclusion: Neither transaminase levels, nor liver failure, were related to a higher mortality rate in this cohort of patients with classic heat stroke.
Topology of Violence
Authors: Han Byung-Chul 
Published: August 2020

One of today's most widely read philosophers considers the shift in violence from visible to invisible, from negativity to excess of positivity.
Some things never disappear—violence, for example. Violence is ubiquitous and incessant but protean, varying its outward form according to the social constellation at hand. In Topology of Violence, the philosopher Byung-Chul Han considers the shift in violence from the visible to the invisible, from the frontal to the viral to the self-inflicted, from brute force to mediated force, from the real to the virtual. Violence, Han tells us, has gone from the negative—explosive, massive, and martial—to the positive, wielded without enmity or domination. This, he says, creates the false impression that violence has disappeared. Anonymized, desubjectified, systemic, violence conceals itself because it has become one with society.
Han first investigates the macro-physical manifestations of violence, which take the form of negativity—developing from the tension between self and other, interior and exterior, friend and enemy. These manifestations include the archaic violence of sacrifice and blood, the mythical violence of jealous and vengeful gods, the deadly violence of the sovereign, the merciless violence of torture, the bloodless violence of the gas chamber, the viral violence of terrorism, and the verbal violence of hurtful language. He then examines the violence of positivity—the expression of an excess of positivity—which manifests itself as over-achievement, over-production, over-communication, hyper-attention, and hyperactivity. The violence of positivity, Han warns, could be even more disastrous than that of negativity. Infection, invasion, and infiltration have given way to infarction.
Portrait of the Manager as a Young Author
Authors: Schönthaler Philipp 
Published: August 2020

What happens to the relationship between business and literature when storytelling becomes a privileged form of communication for organizations.
Corporations love a good story. Microsoft employs a chief storyteller, who heads a team of twenty-five corporate storytellers. IBM, Coca-Cola, and the World Bank are among other organizations that have worked with storytelling methods. And, of course, Steve Jobs was famous for his storytelling. Today, narrative is a privileged form of communication for organizations. In Portrait of the Manager as a Young Author, Philipp Schönthaler explains this unlikely alliance between business and storytelling.
The contradictions are immediately apparent. If, as the philosopher Hans Blumenberg writes, stories are told to pass the time, managers would seem to have little time to spare. And yet, Schönthaler reports, stories are useful in handling complexity. When digital information flows too quickly and exceeds the capacity of the human brain, narrative can provide communicative efficiency and effectiveness. Words and numbers both vouch for truth, are both instrumentalized by management, and are inextricably interdependent.
What happens, if narrative becomes ubiquitous? Does the commercialization of narratives have an effect on literature? Through the lens of storytelling, Schönthaler explores the relationship between economics and literature and describes a form of writing that takes place in their shared spheres. Most books on storytelling in the corporate world are written by business writers; this book offers the perspective of an award-winning literary author, who considers both the impact of storytelling on business and the impact of business on literature.
Zoning China
Authors: Li Luzhou 
Published: August 2020

An examination of “cultural zoning” in China considers why government regulation of online video is so much more lenient than regulation of broadcast television.
In Zoning China, Luzhou Li investigates why the Chinese government regulates online video relatively leniently while tightly controlling what appears on broadcast television. Li argues that television has largely been the province of the state, even as the market has dominated the development of online video. Thus online video became a space where people could question state media and the state's preferred ideological narratives about the nation, history, and society. Li connects this relatively unregulated arena to the “second channel” that opened up in the early days of economic reform—piracy in all its permutations. She compares the dual cultural sphere to China's economic zoning; the marketized domain of online video is the cultural equivalent of the Special Economic Zones, which were developed according to market principles in China's coastal cities.
Li explains that although the relaxed oversight of online video may seem to represent a loosening of the party-state's grip on media, the practice of cultural zoning in fact demonstrates the the state's strategic control of the media environment. She describes how China's online video industry developed into an original, creative force of production and distribution that connected domestic private production companies, transnational corporations, and a vast network of creative labor from amateurs to professional content creators. Li notes that China has increased state management of the internet since 2014, signaling that online and offline censorship standards may be unified. Cultural zoning as a technique of cultural governance, however, will likely remain.