bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large-sample asymptotics of the pseudo-marginal method
Authors: Schmon S M , Deligiannidis G , Doucet A , Pitt M K 
Published: May 2020

SummaryThe pseudo-marginal algorithm is a variant of the Metropolis–Hastings algorithm which samples asymptotically from a probability distribution when it is only possible to estimate unbiasedly an unnormalized version of its density. Practically, one has to trade off the computational resources used to obtain this estimator against the asymptotic variances of the ergodic averages obtained by the pseudo-marginal algorithm. Recent works on optimizing this trade-off rely on some strong assumptions, which can cast doubts over their practical relevance. In particular, they all assume that the distribution of the difference between the log-density, and its estimate is independent of the parameter value at which it is evaluated. Under regularity conditions we show that as the number of data points tends to infinity, a space-rescaled version of the pseudo-marginal chain converges weakly to another pseudo-marginal chain for which this assumption indeed holds. A study of this limiting chain allows us to provide parameter dimension-dependent guidelines on how to optimally scale a normal random walk proposal, and the number of Monte Carlo samples for the pseudo-marginal method in the large-sample regime. These findings complement and validate currently available results.
The Willingness of Social Work Students to Engage in Policy Practice: The Role of Personality Traits and Political Participation Predictors
Authors: Schwartz-Tayri Talia Meital 
Published: May 2020

AbstractThe current study aimed to expand our knowledge regarding social work students’ willingness to engage in policy practice (EPP). A theoretical model integrating the Big Five personality framework with the ‘Civic Voluntarism Model’ (CVM) was examined, using a sample of 160 social work students in Israel. Findings revealed a moderate level of EPP willingness. Among the CVM predictors, political skills, political knowledge and political interest were significantly positively associated with social work students’ EPP willingness. Among the Big Five traits, extroversion, conscientiousness and openness to experience were significantly associated with EPP willingness. Path analysis showed that political skills were the strongest predictor of EPP willingness and that political skills and extroversion had a direct effect on EPP willingness. The significant mediation paths demonstrated the dynamics by which the study predictors interacted in explaining 49 per cent of the variance in EPP willingness. The study concluded that the examination of a model incorporating the Big Five personality traits and modified CVM predictors provided a comprehensive understanding of EPP willingness and, therefore, should be adopted to explain social workers’ actual engagement in policy practice.
Development of Microstructural and Morphological Cortical Profiles in the Neonatal Brain
Authors: Fenchel Daphna , Dimitrova Ralica , Seidlitz Jakob , Robinson Emma C , Batalle Dafnis , Hutter Jana , Christiaens Daan , Pietsch Maximilian , Brandon Jakki , Hughes Emer J , Allsop Joanna , O’Keeffe Camilla , Price Anthony N , Cordero-Grande Lucilio , Schuh Andreas , Makropoulos Antonios , Passerat-Palmbach Jonathan , Bozek Jelena , Rueckert Daniel , Hajnal Joseph V , Raznahan Armin , McAlonan Grainne , Edwards A David , O’Muircheartaigh Jonathan 
Published: May 2020

AbstractInterruptions to neurodevelopment during the perinatal period may have long-lasting consequences. However, to be able to investigate deviations in the foundation of proper connectivity and functional circuits, we need a measure of how this architecture evolves in the typically developing brain. To this end, in a cohort of 241 term-born infants, we used magnetic resonance imaging to estimate cortical profiles based on morphometry and microstructure over the perinatal period (37–44 weeks postmenstrual age, PMA). Using the covariance of these profiles as a measure of inter-areal network similarity (morphometric similarity networks; MSN), we clustered these networks into distinct modules. The resulting modules were consistent and symmetric, and corresponded to known functional distinctions, including sensory–motor, limbic, and association regions, and were spatially mapped onto known cytoarchitectonic tissue classes. Posterior regions became more morphometrically similar with increasing age, while peri-cingulate and medial temporal regions became more dissimilar. Network strength was associated with age: Within-network similarity increased over age suggesting emerging network distinction. These changes in cortical network architecture over an 8-week period are consistent with, and likely underpin, the highly dynamic processes occurring during this critical period. The resulting cortical profiles might provide normative reference to investigate atypical early brain development.
Voluntary Actions Modulate Perception and Neural Representation of Action-Consequences in a Hand-Dependent Manner
Authors: Buaron Batel , Reznik Daniel , Gilron Ro'ee , Mukamel Roy 
Published: May 2020

AbstractEvoked neural activity in sensory regions and perception of sensory stimuli are modulated when the stimuli are the consequence of voluntary movement, as opposed to an external source. It has been suggested that such modulations are due to motor commands that are sent to relevant sensory regions during voluntary movement. However, given the anatomical-functional laterality bias of the motor system, it is plausible that the pattern of such behavioral and neural modulations will also exhibit a similar bias, depending on the effector triggering the stimulus (e.g., right/left hand). Here, we examined this issue in the visual domain using behavioral and neural measures (fMRI). Healthy participants judged the relative brightness of identical visual stimuli that were either self-triggered (using right/left hand button presses), or triggered by the computer. Stimuli were presented either in the right or left visual field. Despite identical physical properties of the visual consequences, we found stronger perceptual modulations when the triggering hand was ipsi- (rather than contra-) lateral to the stimulated visual field. Additionally, fMRI responses in visual cortices differentiated between stimuli triggered by right/left hand. Our findings support a model in which voluntary actions induce sensory modulations that follow the anatomical-functional bias of the motor system.
Relationship Between Odor Intensity Estimates and COVID-19 Prevalence Prediction in a Swedish Population
Authors: Iravani Behzad , Arshamian Artin , Ravia Aharon , Mishor Eva , Snitz Kobi , Shushan Sagit , Roth Yehudah , Perl Ofer , Honigstein Danielle , Weissgross Reut , Karagach Shiri , Ernst Gernot , Okamoto Masako , Mainen Zachary , Monteleone Erminio , Dinnella Caterina , Spinelli Sara , Mariño-Sánchez Franklin , Ferdenzi Camille , Smeets Monique , Touhara Kazushige , Bensafi Moustafa , Hummel Thomas , Sobel Noam , Lundström Johan N 
Published: May 2020

Abstract
In response to the coronavirus disease 2019 (COVID-19) pandemic, countries have implemented various strategies to reduce and slow the spread of the disease in the general population. For countries that have implemented restrictions on its population in a stepwise manner, monitoring of COVID-19 prevalence is of importance to guide the decision on when to impose new, or when to abolish old, restrictions. We are here determining whether measures of odor intensity in a large sample can serve as one such measure. Online measures of how intense common household odors are perceived and symptoms of COVID-19 were collected from 2440 Swedes. Average odor intensity ratings were then compared to predicted COVID-19 population prevalence over time in the Swedish population and were found to closely track each other (r = −0.83). Moreover, we found that there was a large difference in rated intensity between individuals with and without COVID-19 symptoms and the number of symptoms was related to odor intensity ratings. Finally, we found that individuals progressing from reporting no symptoms to subsequently reporting COVID-19 symptoms demonstrated a large drop in olfactory performance. These data suggest that measures of odor intensity, if obtained in a large and representative sample, can be used as an indicator of COVID-19 disease in the general population. Importantly, this simple measure could easily be implemented in countries without widespread access to COVID-19 testing or implemented as a fast early response before widespread testing can be facilitated.
One-Year Quality of Life Post–Pneumonia Diagnosis in Japanese Adults
Authors: Glick Henry A , Miyazaki Taiga , Hirano Katsuji , Gonzalez Elisa , Jodar Luis , Gessner Bradford D , Isturiz Raul E , Arguedas Adriano , Kohno Shigeru , Suaya Jose A 
Published: May 2020

Abstract

Background
Pneumonia is a common, serious illness in the elderly, with a poorly characterized long-term impact on health-related quality of life (HRQoL). The Japanese Goto Epidemiology Study is a prospective, active, population-based surveillance study of adults with X-ray/CT scan–confirmed community-onset pneumonia, assessing the HRQoL outcome quality-adjusted life-years (QALYs). We report QALY scores and losses among a subset of participants in this study.

Methods
QALYs were derived from responses to the Japanese version of the EuroQol-5D-5L health-state classification instrument at days 0, 7, 15, 30, 90, 180, and 365 after pneumonia diagnosis from participants enrolled from June 2017 to May 2018. We used patients as their own controls, calculating comparison QALYs by extrapolating EuroQol-5D-5L scores for day −30, accounting for mortality and changes in scores with age.

Results
Of 405 participants, 85% were aged ≥65 years, 58% were male, and 69% were hospitalized for clinically and radiologically confirmed pneumonia. Compliance with interviews by patients or proxies was 100%. Adjusted EuroQol-5D-5L scores were 0.759, 0.561, 0.702, and 0.689 at days −30, 0 (diagnosis), 180, and 365, respectively. Average scores at all time points remained below the average day −30 scores (P ≤ .001). Pneumonia resulted in a 1-year adjusted loss of 0.13 QALYs (~47.5 quality-adjusted days) (P &lt; .001).

Conclusions
Substantial QALY losses were observed among Japanese adults following pneumonia diagnosis, and scores had not returned to prediagnosis levels at 1 year postdiagnosis. QALY scores and cumulative losses were comparable to those in US adults with chronic heart failure, stroke, or renal failure.
Farnesoid X Receptor-Mediated Cytoplasmic Translocation of CRTC2 Disrupts CREB-BDNF Signaling in Hippocampal CA1 and Leads to the Development of Depression-Like Behaviors in Mice
Authors: Hu Wenfeng , Wu Jingjing , Ye Ting , Chen Zhuo , Tao Jinhua , Tong Lijuan , Ma Kai , Wen Jie , Wang Hui , Huang Chao 
Published: May 2020

Abstract

Background
We recently identified neuronal expression of farnesoid X receptor (FXR), a bile acid receptor known to impair autophagy by inhibiting cyclic adenosine monophosphate response element-binding protein (CREB), a protein whose underfunctioning is linked to neuroplasticity and depression. In this study, we hypothesize that FXR may mediate depression via a CREB-dependent mechanism.

Methods
Depression was induced in male C57BL6/J mice via chronic unpredictable stress (CUS). Subjects underwent behavioral testing to identify depression-like behaviors. A variety of molecular biology techniques, including viral-mediated gene transfer, Western blot, co-immunoprecipitation, and immunofluorescence, were used to correlate depression-like behaviors with underlying molecular and physiological events.

Results
Overexpression of FXR, whose levels were upregulated by CUS in hippocampal CA1, induced or aggravated depression-like behaviors in stress-naïve and CUS-exposed mice, while FXR short hairpin RNA (shRNA) ameliorated such symptoms in CUS-exposed mice. The behavioral effects of FXR were found to be associated with changes in CREB-brain-derived neurotrophic factor (BDNF) signaling, as FXR overexpression aggravated CUS-induced reduction in BDNF levels while the use of FXR shRNA or disruption of FXR-CREB signaling reversed the CUS-induced reduction in the phosphorylated CREB and BDNF levels. Molecular analysis revealed that FXR shRNA prevented CUS-induced cytoplasmic translocation of CREB-regulated transcription coactivator 2 (CRTC2); CRTC2 overexpression and CRTC2 shRNA abrogated the regulatory effect of FXR overexpression or FXR shRNA on CUS-induced depression-like behaviors.

Conclusions
In stress conditions, increased FXR in the CA1 inhibits CREB by targeting CREB and driving the cytoplasmic translocation of CRTC2. Uncoupling of the FXR-CREB complex may be a novel strategy for depression treatment.
Dual role of splenic mononuclear and polymorphonuclear cells in the outcome of ciprofloxacin treatment of Salmonella enterica infections
Authors: Kanvatirth P , Rossi O , Restif O , Blacklaws B A , Tonks P , Grant A J , Mastroeni P 
Published: May 2020

Abstract

Objectives
To determine the immune cell populations associated with Salmonella enterica serovar Typhimurium before and after ciprofloxacin treatment using a murine model of systemic infection. The effect of depletion of immune cells associating with Salmonella on treatment outcome was also determined.

Methods
We infected mice with a Salmonella enterica serovar Typhimurium strain expressing GFP and used multicolour flow cytometry to identify splenic immune cell populations associating with GFP-positive Salmonella before and after treatment with ciprofloxacin. This was followed by depletion of different immune cell populations using antibodies and liposomes.

Results
Our results identified CD11b+CD11chi/lo (dendritic cells/macrophages) and Ly6G+CD11b+ (neutrophils) leucocytes as the main host cell populations that are associated with Salmonella after ciprofloxacin treatment. We therefore proceeded to test the effects of depletion of such populations during treatment. We show that depletion of Ly6G+CD11b+ populations resulted in an increase in the number of viable bacterial cells in the spleen at the end of ciprofloxacin treatment. Conversely, treatment with clodronate liposomes during antimicrobial treatment, which depleted the CD11b+CD11chi/lo populations, resulted in lower numbers of viable bacteria in the tissues.

Conclusions
Our study identified host cells where Salmonella bacteria persist during ciprofloxacin treatment and revealed a dual and opposing effect of removal of Ly6G+CD11b+ and CD11b+CD11chi/lo host cells on the efficacy of antimicrobial treatment. This suggests a dichotomy in the role of these populations in clearance/persistence of Salmonella during antimicrobial treatment.
Utilizing antibiotics to prevent Clostridioides difficile infection: does exposure to a risk factor decrease risk? A systematic review
Authors: Carlson Travis J , Gonzales-Luna Anne J 
Published: May 2020

Abstract

Background
Antibiotic use is a major risk factor for Clostridioides difficile infection (CDI). However, antibiotics recommended for CDI treatment are being utilized in clinical practice as prophylactic agents.

Objectives
To comprehensively summarize and critically evaluate the published literature investigating the effectiveness of antibiotic CDI prophylaxis.

Methods
A systematic search for relevant literature was conducted in PubMed and ClinicalTrials.gov. Two investigators independently screened each article for inclusion, and the references of the included articles were studied to identify additional relevant articles. Data extraction and an assessment of risk of bias was completed for all included studies. Unadjusted risk ratios and 95% CI were calculated for each study, with CDI being the outcome variable and prophylaxis (prophylaxis versus control) representing the exposure.

Results
In total, 13 articles were identified in PubMed and 9 ongoing or unpublished trials were identified in ClinicalTrials.gov. The effect of antibiotic prophylaxis on CDI rates varied between studies; however, most favoured the use of antibiotic prophylaxis.

Conclusions
The authors of this review conclude that the current literature carries a high risk of bias and the results should be interpreted with caution.
De-Extinction, Regulation and Nature Conservation
Authors: Allen Jessica , Doyle David M , McCorristine Shane , McMahon Aisling 
Published: May 2020

Abstract
This analysis maps the key challenges posed by de-extinction to nature conservation law. The aim is to start a conversation about how such challenges should be framed and addressed if ongoing de-extinction projects in the United States of America (US) and the European Union (EU), the two jurisdictions examined, are successful. The analysis commences by providing a brief overview of existing debates in the conservation literature on the legal and ethical issues posed by de-extinction within the animal context. The article then proceeds to highlight two challenges animals created via de-extinction (de-extinctees) will likely pose for nature conservation law, namely: (1) to what extent taxonomies or definitions of ‘species’, and the methods for classifying these species under existing conservation frameworks, will be challenged by de-extinction; and (2) how existing conservation law frameworks in the US and the EU would likely apply to de-extinctees, and whether de-extinctees would be protected under these frameworks. It concludes by posing the broader question of whether and to what extent the law should facilitate de-extinction attempts in the same way that it has done for nature conservation.
Risk of Rare Cancers Among Solid Organ Transplant Recipients
Authors: D’Arcy Monica E , Castenson David , Lynch Charles F , Kahn Amy R , Morton Lindsay M , Shiels Meredith S , Pfeiffer Ruth M , Engels Eric A 
Published: May 2020

Abstract

Background
Immunosuppressed solid organ transplant recipients (SOTRs) have elevated rates of certain rare cancers caused by viruses. Evaluating risk of rare cancers among SOTRs may provide etiological clues for additional cancers linked to poor immunity and viral infections.

Methods
We performed a cohort study of 262 455 SOTRs (1987-2014) from the US SOTR registry linked to 17 population-based cancer registries. First cancers in SOTRs were categorized using an established classification scheme based on site and histology. Standardized incidence ratios (SIRs) compared risk in SOTRs with the general population. We used Poisson regression to calculate incidence rate ratios according to immune-related SOTR characteristics, including time since transplant (ie, duration of immunosuppression). All statistical tests were 2-sided.

Results
We examined 694 distinct cancer subtypes, with 33 manifesting statistically significantly elevated SIRs (Bonferroni P &lt; 7.2 × 10–5). All 33 are rare (incidence &lt;6 per 100 000 person-years) and several have known viral etiology (eg, Merkel cell carcinoma: SIR = 24.7, 95% confidence interval [CI] = 20.8 to 29.1). Additional cancers that were increased include squamous cell carcinomas of the lip (SIR range = 18.3-19.8), eye and adnexa (SIR = 13.8, 95% CI = 7.9 to 22.3), salivary gland (SIR = 9.3, 95% CI = 6.1 to 13.5), and nasal cavity and sinuses (SIR = 4.5, 95% CI = 2.8 to 6.8); sebaceous adenocarcinoma (SIR = 34.3, 95% CI = 26.3 to 44.0); malignant fibrous histiocytoma (15.4); and subtypes of bladder, kidney, lung, and colon cancer (SIR range = 3.2-13.3). Incidence of several cancers increased over time since transplant (Ptrend &lt; .05), including squamous cell carcinomas of the lip, salivary gland, and anogenital sites.

Conclusions
SOTRs experience elevated rates of several rare cancers. Because some of these cancers exhibit aggressive behavior with poor outcomes, it is important to further characterize the role of immunity and the potential involvement of oncogenic viruses to improve prevention and treatment.
Aboveground herbivory increases soil nematode abundance of an invasive plant
Authors: Liu Jia , Dai Susu , Huang Wei , Ding Jianqing 
Published: May 2020

AbstractAimsPlant invasions have the potential to affect the community structure of soil nematodes, but little is known about whether such effects are mediated by aboveground herbivores since invasive plants are not completely released from herbivores in the introduced range. In this study, we explored how aboveground insect herbivores mediated the effect of invasive plant Alternanthera philoxeroides on soil nematodes and examined the temporal variations of such an herbivory-elicited effect.MethodsWe conducted a greenhouse experiment by applying different herbivory treatments (no insect herbivores, specialist Agasicles hygrophila and generalist Cassida piperata) to potted A. philoxeroides, and then measured the community compositions of soil nematodes in corresponding pots on the 1st, 10th and 20th day after removal of all herbivores. In addition, the carbon content of roots and root exudate of A. philoxeroides were also measured.Important FindingsOur results showed that aboveground herbivory significantly increased the abundance of soil nematodes of A. philoxeroides, likely plant feeder nematodes, after insect herbivores were removed immediately (1st day). However, such impacts waned with time and there was no significant difference at later stages (10th and 20th days). Furthermore, the effects of specialist A. hygrophila and generalist C. piperata herbivory were consistent on the abundance of soil nematodes. Overall, our results suggest that aboveground insect herbivores have the potential to alter the effects of plant invasions on soil nematodes, but such impacts are transient. Furthermore, our study highlighted the importance of integrating the effects of above- and belowground organisms when evaluating the impacts of plant invasions.
Environmental pressure rather than ongoing hybridization is responsible for an altitudinal cline in the morphologies of two oaks
Authors: Tamaki Ichiro , Yamada Yae 
Published: May 2020

AbstractAimsIn a contact zone between related taxa, phenotypic variation can result from genetic and/or environmental gradients. This study aimed to clarify the cause of phenotypic variation in leaf morphology of two Quercus crispula varieties—crispula (QCC) and mongolicoides (QCM)—in their contact zone along an altitudinal gradient.MethodsWe measured 6 morphological traits of leaves and recorded genotypes of 13 nuclear microsatellite loci for 48 individuals in the contact zone and 24 individuals in each of the reference populations of QCC and QCM. We constructed a model explaining the phenotypic variation (leaf morphology) in relation to environmental (altitude) and genetic (ancestry from the reference population) gradients.Important FindingsBoth morphological and genetic markers distinguished the two varieties in the reference populations well. We were able to confirm the power of both morphological and genetic markers. Individuals within the contact zone population had intermediate ancestry that was slightly biased to QCM ancestry, and the distribution of their morphologies overlapped with those of the two varieties in the reference populations. The effect of altitude on leaf morphological traits was significant, while that of ancestry was not. Distributions of ancestry and interclass heterozygosity in the contact zone population resembled those in F2 or later generation hybrids. These results indicate that in the contact zone between QCC and QCM, there is no ongoing hybridization, but environmental pressure has created an altitudinal gradient in morphological traits through phenotypic plasticity and/or variation in functional genes.