bluuebunny/crossref_metadata_2025_split huggingface dataset:
An in-silico approach to develop of a multi-epitope vaccine candidate against SARS-CoV-2 envelope (E) protein
Authors: Ghafouri Fatemeh , Cohan Reza Ahangari , Noorbakhsh Farshid , Samimi Hilda , Haghpanah Vahid 
Published: May 2020

Abstract
Since the first appearance of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS- CoV-2) in China on December 2019, the world has now witnessed the emergence of the SARS- CoV-2 outbreak. Therefore, due to the high transmissibility rate of virus, there is an urgent need to design and develop vaccines against SARS-CoV-2 to prevent more cases affected by the virus. In this study, a computational approach is proposed for vaccine design against the envelope (E) protein of SARS-CoV-2, which contains a conserved sequence feature. First, we sought to gain potential B-cell and T-cell epitopes for vaccine designing against SARS-CoV-2. Second, we attempted to develop a multi-epitope vaccine. Immune targeting of such epitopes could theoretically provide defense against SARS-CoV-2. Finally, we evaluated the affinity of the vaccine to major histocompatibility complex (MHC) molecules to stimulate the immune system response to this vaccine. We also identified a collection of B-cell and T-cell epitopes derived from E proteins that correspond identically to SARS-CoV-2 E proteins. The in-silico design of our potential vaccine against E protein of SARS-CoV-2 demonstrated a high affinity to MHC molecules, and it can be a candidate to make a protection against this pandemic event.
Tumor-targeted Drug Delivery by Nanocomposites
Authors: Baker Abu , Khan Mohd Salman , Iqbal Muhammad Zafar , Khan Mohd Sajid 
Published: May 2020

Background:
Tumor-targeted delivery by nanoparticles is a great achievement towards the use of highly
effective drug at very low doses. The conventional development of tumor-targeted delivery by nanoparticles is based
on enhanced permeability and retention (EPR) effect and endocytosis based on receptor-mediated are very
demanding due to the biological and natural complications of tumors as well as the restrictions on the design of the
accurate nanoparticle delivery systems.

Methods:
Different tumor environment stimuli are responsible for triggered multistage drug delivery systems
(MSDDS) for tumor therapy and imaging. Physicochemical properties, such as size, hydrophobicity and potential
transform by MSDDS because of the physiological blood circulation different, intracellular tumor environment. This
system accomplishes tumor penetration, cellular uptake improved, discharge of drugs on accurate time, and
endosomal discharge.

Results:
Maximum drug delivery by MSDDS mechanism to target therapeutic cells and also tumor tissues and sub
cellular organism. Poorly soluble compounds and bioavailability issues have been faced by pharmaceutical
industries, which are resolved by nanoparticle formulation.

Conclusion:
In our review, we illustrate different types of triggered moods and stimuli of the tumor environment,
which help in smart multistage drug delivery systems by nanoparticles, basically a multi-stimuli sensitive delivery
system, and elaborate their function, effects, and diagnosis.
Acidic Ionic Liquid-catalyzed Synthesis of Pyrano[4,3-b]pyran-5(4H)-ones using 4,4,4-trifluoro-1-phenylbutane-1,3-dione as a Building Block
Authors: Shahi Akbar Massoumi , Nikpassand Mohammad , Fekri Leila Zare 
Published: May 2020

Aims:
synthesis of pyrano[c-2,3]chromens with Ionic Liquid catalyst with simple method.

Background:
Synthesis of pyrano[c]coumarins has a special place in the structure due to two bioactive compounds
in its structure and attracts a great deal of attention in this research work, it has been attempted to attach
chromatically valuable skeletons to them and synthesize the pyrano [c] coumarines, which can potentially have
high biological properties. For this purpose, electrophilic β-ketoester ringing in the presence of ionic liquid catalysts
was used. While optimizing the catalyst recovery, it is possible to synthesize several coumarine pyrano[
c]derivatives with high yield.

Objective:
This paper describes an efficient procedure for the multi-component reaction of aromatic aldehydes,
4,4,4-Trifluoro-1-phenyl-1,3-butanedione and 4-hydroxycoumarinwhich catalyzed by Ioniq liquid (OlmDSA), at
room temperature. This catalyst was synthesized with new simple procedure. This protocol has advantages of
simplicity, mild condition and high yield.

Materials and Methods:
After formation of a new stain corresponding to the alkene intermediate, 4-hydroxy
coumarin (1 mM) was added. The reaction was progressed by thin layer chromatography in a 1: 2 ratio solvent
containing ethyl acetate and hexane. The reaction mixture was then stirred for one hour. After the reaction was
complete, the catalyst was first removed by washing. Ethanol was then added to the reaction residue and washed
and finally filtered. The residual solid on the filter paper after drying was considered as the product and was taken
to confirm. its structure, melting point and spectra. The following is a general overview of the reaction.

Results and Discussion:
In addition to the advantages mentioned for this tri-component reaction, the conservation
of the coumarin ring is very important in this research design because it is formed in many of the reported
open reactions and phenolic ring.

Conclusion:
The benefits of this work include simple reaction steps, review of reaction progress by TLC chromatography,
simple separation of the catalyst by washing and reuse for three times without any reduction in yield
and high reaction yield.
Molecular Docking Studies of Glycyrrhetinic Acid Derivatives as Anti-Colorectal Cancer Agents
Authors: Doan Nam Q.H. , Truong Tuyen N. , Nguyen Phuong T.V. 
Published: May 2020

Background:
In this study, the anti-colorectal cancer (CRC) activities of 40 glycyrrhetinic
acid derivatives were proposed and evaluated by the molecular docking method, which allowed
the flexibility of both ligand-receptor, with twelve CRC-related targets.

Methods:
The proposed derivatives, which clearly distinguish isomers at position 18 as well as the
different tautomers, were divided into five groups, including (1) glycyrrhetinic acid and its oxidation
derivatives, (2) glycoside derivatives, (3) 3β-amine derivatives, (4) five-membered heterocyclic
ring-combined derivatives, and (5) six-membered heterocyclic ring-combined derivatives.

Results:
Finally, four out of twelve proposed targets related to CRC with good binding affinities to the proposed
glycyrrhetinic acid derivatives were selected, including Epidermal Growth Factor Receptor (EGFR),
Focal Adhesion Kinase (FAK), Lactate Dehydrogenase A (LDHA), and Thymidylate Synthase (TS).

Conclusion:
From there, 9/40 derivatives for EGFR (pKd ≥ 9); 10/40 derivatives for FAK (pKd ≥
10); 9/40 derivatives for LDHA (pKd ≥ 10), and 6/40 derivatives for TS (pKd ≥ 9) were also obtained.
The glycoside derivatives showed the best binding affinity (especially the glucuronide derivative
5b), followed by the 3β-amino derivatives (especially the 3β-(phenylamino) derivative 8b) and
the five-membered heterocyclic ring-combined derivatives (especially the pyrrole derivative 10a or
pyrazole derivative 11.2a), while the six-membered heterocyclic ring-combined derivatives had less
potential to inhibit the 4 selected targets.
The Cannabis Spread throughout the Continents and its Therapeutic Use in History
Authors: Charitos Ioannis A. , Gagliano-Candela Roberto , Santacroce Luigi , Bottalico Lucrezia 
Published: May 2020

Background:Cannabis sativa L. (C. sativa) is a plant whose use as a therapeutic agent shares its origins with the first Far East’s human societies. Cannabis has been used not only for recreational purposes but as food to obtain textile fibers, to produce hemp paper, to treat many physical and mental disorders.Aim:This review aims to provide a complete assessment of the deep knowledge of the cannabis psychoactive effects and medicinal properties in the course of history covering i.) The empirical use of the seeds and the inflorescences to treat many physical ailments by the ancient Oriental physicians’ ii.) The current use of cannabis as a therapeutic agent after the discovery of its key psychoactive constituent and the human endogenous endocannabinoid system.Methods:This study was performed through a detailed analysis of the studies on the historical significance and medical applications of Cannabis sativa by using international scientific databases, historical and medical books, ancient Greek and Chinese manuscripts translations, library and statistical data from government reports and texts from the National Library of Greece (Stavros Niarchos Foundation), from the School of Health Sciences of the National and Kapodistrian University of Athens (Greece). We selected papers and texts focusing on a historical point of view about the medical importance of the plant and its applications for a therapeutic purpose in the past.Results and conclusion:Through a detailed analysis of the available resources about the origins of C. sativa, we found that its use by ancient civilizations as a source of food and textile fibers dates back over 10,000 years, while its therapeutic applications have been improved over the centuries, from the ancient East medicine of the 2nd and 1st millennium B.C. to the more recent introduction in the Western world after the 1st century A.D. In the 20th and 21st centuries, Cannabis and its derivatives have been considered as a menace and banned throughout the world, but nowadays, they are still the most widely consumed illicit drugs all over the world. Its legalization in some jurisdictions has been accompanied by new lines of research to investigate its possible applications for medical and therapeutic purposes.
Indoor Air Pollution and Respiratory Function on Primary School Students in West Jakarta, Indonesia
Authors: Mulia Gelora J.T. , Wispriyono Bambang , Kusnoputranto Haryoto , Hartono Budi , Rozaliyani Anna 
Published: May 2020

Background:This study aimed to investigate the relationship between air pollutant exposure,i.e.,Particulate Matter (PM2,5), and the numbers of airborne bacterial colonies inside the classroom to the respiratory symptoms of three primary school children in West Jakarta.Methods:We did a quantitative study with a cross-sectional design using variables,i.e., age, sex, physical activity, nutritional status, students’ density, ventilation, classroom temperature, and classroom humidity. We used Haz-Dust EPAM 5000 to measure PM2,5,MAS 100 NT to calculate the total bacterial colony, spirometry to measure the respiratory capacity, and questionnaire to measure other related variables.Results:We found a significant relationship between PM2,5concentration with respiratory symptoms, however, there was no significant relationship between the total number of airborne bacterial colonies with respiratory symptoms.Conclusion:Based on our results, we conclude that there was a significant relationship between the PM2,5concentration and obstructive pulmonary symptoms and there was no significant relationship between the numbers of the bacterial colonies with pulmonary symptoms.
A CONSTITUIÇÃO DA IDENTIDADE NEGRA NO LIVRO PARA INFÂNCIA BETINA, DE NILMA LINO GOMES
Authors: Da Cunha Fabienne Neide Neide , DEBUS ELIANE SANTANA DIAS , Dos Passos Joana Célia 
Published: May 2020

A Lei 10.639/2003 é uma das Políticas de Ações Afirmativas que incidiu diretamente na educação para as relações étnico-raciais, visando fomentar nos(as) profissionais da educação novas lentes para o ensino de história e da literatura afro-brasileira, servindo como um dispositivo impulsionador para mobilizar a cidadania e descortinar as práticas racistas ainda presentes nos ambientes educacionais e na sociedade. A produção literária para a infância pode problematizar as relações étnico-raciais? Ela é capaz de contribuir para a valorização e a constituição identitária do/a criança negro/a? Acreditando positivamente, o presente artigo traz à cena o livro Betina, de Nilma Lino Gomes, buscando evidenciar na sua construção textual, em particular por meio do protagonismo negro infantil, um discurso em que os preconceitos raciais são (re)significados possibilitando que ocorra a constituição identitária de negros e negras, desde a infância, sob uma perspectiva desprovida das marcas inferiorizantes advindas do racismo.
Fundación Democrática, Ciudadanía, y Democracia Procedimental. Una Mirada a Centroamérica
Authors: Ocampo Banda Luis E. , Lizarraga Patrón Adolfo 
Published: May 2020

Las transiciones democráticas que se desprendieron de los procesos democratizadores en América Latina en la década de los 80, han cumplido casi en su totalidad su desarrollo de etapa primaria, esto es, de consolidar las instituciones que organizan los aspectos procedimentales de las elecciones, asignar un lugar a cada actor político y establecer las reglas del juego para que las contiendas electorales se den en tiempo y forma.
Los resultados no son homogéneos para todos los países latinoamericanos, dado que cada realidad nacional tiene componentes específicos que le imprimen una dinámica particular a cada iniciativa democratizadora. Aunado a ello es necesario puntualizar que no todas las transiciones tuvieron el mismo perfil sino que, de acuerdo a las características del país, la situación que prevalecía políticamente en el interior de la nación y relación de los actores políticos entre sí fue lo que dio el sello y perfil de la transición; de acuerdo a Garreton, algunas tuvieron el carácter fundacional, otras de lo militar a gobierno cívico y la de extensión o afianzamiento
La Narración y las Vicisitudes de un Escritor
Authors: Núñez Villavicencio Herminio 
Published: May 2020

En estas líneas se desarrolla y amplía parte del proyecto de investigación “Relaciones entre historia y literatura”, trabajo que ha conducido a ver la cuestión de la narración en historia y literatura como reciente y posmoderna, en cuanto cuestiona certezas de la modernidad, tanto en el campo epistemológico, como en la demarcación de territorios disciplinarios y sus aspiraciones de ciencia.
El proyecto de investigación del que deriva el escrito fue motivado por la lectura del libro Yo, el francés. Biografías y crónicas. La intervención en primera persona, de Jean Meyer, quien conjetura que la normativa de la narración histórica no difiere, en demasía, con la elaboración de una novela ambientada en el pasado. Dado que lo expresado por los datos es trabajado a partir de interpretaciones que se abren como posibilidades de significación, que pueden o no constituir una visión oficial.
Desarrollo y Avatares de la Política Cultural en Cuba: 1959-1986
Authors: Martínez Tapia Mtra. en E. L. Judith 
Published: May 2020

La Revolución cubana, como uno de los procesos de mayor envergadura social en América Latina, sin estar exenta de esta dinámica del cambio, trajo también consigo nuevas concepciones en diferentes ámbitos de la sociedad, que no se limitaban al mejoramiento de las condiciones materiales de la población, sino también de las espirituales, como uno de los aspectos fundamentales en la vida de una nación.En este trabajo se expone el resultado de la investigación sobre el desarrollo de la política cultural de la Revolución Cubana, en un lapso que va de 1959 (inicio de la construcción de la república socialista) a 1986 (inicio del período de rectificación).
La Filosofía ante el Proceso Neoliberal y las Reacciones de los Movimientos Sociales en Venezuela (1990-2010)
Authors: Méndez Reyes Johan , Morán Beltrán Lino 
Published: May 2020

El presente trabajo pretende analizar el papel de la filosofía y de los movimientos sociales en Venezuela durante 1990-2010 ante los desafíos de las políticas neoliberales. La metodología que se utilizará es la hermenéutica para comprender e interpretar los hechos más representativos acontecidos en la Venezuela de finales del siglo XX e inicio del siglo XXI y el papel que ha jugado la filosofía y los distintos movimientos sociales en nuestra sociedad en la era neoliberal. En esta investigación se concluye que los acontecimientos del Caracazo de 1989 y el inicio de la Revolución Bolivariana de 1999, constituyen dos hitos de la historia reciente venezolana que sin lugar a dudas han tenido su impronta en el desarrollo del debate filosófico nacional actual.
Carnaval y Sociedad Anómica Colombiana en la Carroza de Bolívar de Evelio Rosero Diago
Authors: Verdugo Ponce Jorge 
Published: May 2020

Dentro del listado de nuevas novelas históricas colombianas, se publica a comienzos del año 2012 la novela La carroza de Bolívar de Evelio Rosero Diago, escritor de ascendencia nariñense, obra que revela en el sur la compleja realidad de la sociedad colombiana en permanente crisis debido a su fundación a deshora, construida sobre una enorme mentira, la del Bolívar gran militar preocupado por la moralidad pública, y cuyo nefasto ejemplo dado por el “mal llamado Libertador” fundó lo que sería con el tiempo la cultura política colombiana, según la afirmación que hace el doctor Justo Pastor Proceso López, afamado ginecólogo de la ciudad de Pasto, lugar donde se desarrollan los acontecimientos en plena fiesta de carnaval de Blancos y Negros entre el 28 de diciembre de 1966 y hasta el 6 de enero del 67, personaje éste que pretende desarrollar en su vida, por una parte, un proyecto político denunciando, a la manera de Sañudo con sus Estudios sobre la vida de Bolívar, las mentiras dichas sobre Bolívar, y para lo cual patrocinará una carroza con su figura para recordar a la gente del sur su historia pasada, además de su otro proyecto consistente en conseguir el amor de su mujer y el cariño de sus hijas, proyectos que se desarrollarán paralelamente en la historia de la novela, y que terminarán con el asesinato del médico por parte de una célula del ejército de liberación nacional que, a través de su accionar contradictorio, busca limpiar la honra de Bolívar, supuestamente difamada por el protagonista.
La visión carnavalizada del mundo que ofrece el texto y gracias a la cual se permiten algunas libertades que posibilitarán el desarrollo de los proyectos de vida del médico, revelarán la condición de una sociedad anómica generalizada, esto es la existencia de un Estado anómico como lo es el colombiano y, por supuesto, la sociedad del sur del país, regida por una normatividad desprestigiada que contribuye a su desinstitucionalización, y cuyas causas se remontan a los orígenes mismos de fundación de la patria y ante lo cual, recordando el pasado de la región y el cronotopo idílico en el que moraban sus habitantes, se busca recobrar lo perdido, esto es, una forma de vida armoniosa y justa libre de vejámenes y mentiras. Rosero adopta una posición ideológica suprapartidista en su evaluación de la realidad colombiana lo que le permite llevar a cabo su propuesta a través de la verdad de revelación propia del trabajo estético.
On the Strategic Directions of the EEU Development
Authors: Glazyev S. Y. 
Published: May 2020

The article analyzes the reasons for incomplete integration processes, substantiates proposals for their elimination and further development of integration, based on the goals set by the heads of EEU states in the Declaration on the further development of integration processes within the EEU.The priority task of EEU further development is to complete a full-fledged Common economic space in a timely manner and start implementing a common policy for industry, agriculture, energy, transport and infrastructure, and finance. The system of measures necessary for improving the activities of the Eurasian economic Commission and ensuring high efficiency of the EEU common market regulation and its advanced development is considered.
ANALECTA VETERINARIA en tiempos de pandemia
Authors: Portiansky Enrique 
Published: May 2020

ANALECTA VETERINARIA, órgano oficial de comunicación científica de la Facultad de Ciencias Veterinarias de la Universidad Nacional de La Plata, ya ha cumplido 115 años desde su creación, con el nombre de “Revista de la Facultad de Agronomía y Veterinaria de La Plata”, y 50 años desde la instauración de su actual denominación. Hoy, como antaño, Analecta Veterinaria se compromete con el saber científico en el área de las ciencias veterinarias, sea este correspondiente a conocimientos básicos, como aquellos que se relacionan con las prácticas clínicas, la producción agropecuaria y los alimentos destinados al consumo humano y animal.
La pandemia del COVID­19 ha golpeado, en mayor o en menor medida, sobre cada puerta de nuestro planeta y ha cambiado, en poco tiempo, muchos de los aspectos de nuestras vidas. Las prácticas profesionales se han visto reducidas y los laboratorios de investigación prácticamente están cerrados. Ante esta situación, los resultados que se puedan obtener en los próximos meses surgirán, mayoritariamente, del análisis de los datos obtenidos con anterioridad a la declaración de la pandemia o de los que obtengan aquellos grupos beneficiados a través de los subsidios otorgados por organismos gubernamentales o privados para afrontar la situación epidemiológica.
A partir de todo evento desafortunado surgen las ideas más brillantes para sobrellevarlo y esta pandemia no está exenta de ese principio. Día a día se leen artículos en revistas científicas que proponen nuevos o antiguos tratamientos para combatir al coronavirus. Con una celeridad nunca antes vista estamos conociendo nuevos aspectos de la enfermedad y diferentes grupos de investigadores de diferentes partes del mundo se aúnan para potenciar sus conocimientos. Sin embargo, es tiempo de ser responsables. Es fundamental que los resultados que se pretendan publicar hayan sido científicamente consolidados bajo las estrictas normas del método científico y los estándares de la ética que la situación requiere. Generar conocimiento científico es un proceso lento y tedioso, el que finalmente requiere del rigor de la aceptación por parte de pares.
Desde ANALECTA VETERINARIA instamos a seguir trabajando en beneficio de la ciencia, cada uno en su área específica, dando lo mejor de sí. La pandemia del coronavirus es coyuntural, aún no ha finalizado o su final es incierto, pero nos dejará una enseñanza: debemos estar preparados científicamente para afrontar cualquier situación emergente.

Consejo Editorial ANALECTA VETERINARIA
A Meta-Analysis of User Perception and Use of Online Digital Platforms in Kenya: Evidence from E-citizen Platform, Kenya
Authors: Morrisson Kaunda Mutuku (PhD)  
Published: May 2020

This paper sought to establish the effect of user perception on use of online digital platforms in Kenya with evidence from e-citizen platform in Kenya. This paper conducted a desktop analysis of published papers on user perceptions and the adoption of e-citizen platforms in Kenya. The results revealed that user perception has a significant effect on the adoption and use of online digital platforms. The findings further showed that in various ways that user perceptions especially on digital platforms security and privacy, usefulness, ease of use, complexity, speed, efficiency, and affordability among others significantly influenced the adoption and use of e-citizen platforms in Kenya.
There is a need for awareness campaigns among the target users. Because of various experiences the user have had with other online platforms, implementers of new platforms have a role to play in changing the use perceptions that targeted user may have due to previous interactions. The increase in the cases of cyber-crimes where malicious people have access to people's personal data has eroded many people's confidence and trust in the online platforms, hence it is a responsibility of the government to guarantee users of these online platforms of their security and privacy to increase adoption and use.