bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Difference of Amino Acid Profiling From Two Morphological Purple Sweet Potatoes From Kawi Mountain Cultivars, East Java, Indonesia
Authors: Kurnianingsih N , Ratnawati R , Fatchiyah F , Barlianto W , Ali M M , Safitri A , Suyanto E 
Published: November 2019

Abstract
Indonesia is one of the main commercial producers of sweet potatoes. Previous study has presented well documented anthocyanin content of Purple Sweet Potatoes (PSP) from local cultivar in Indonesia. However, research about amino acids profiling of local cultivar PSP as high commodities in Kawi Mountain region has not undertaken. This study was explored amino acids profiles in two morphological PSP cultivated in Kawi Mountain region, Ngajum Village, Wonosari Subdistric, Malang Regency, East Java, Indonesia. Fresh storage roots were cleaned with running water and shade dried. The analysis was conducted at PT.Saraswanti Indo Genetech, Bogor, Indonesia. Method of UPLC was used for identification of Ser, Glu, Phe, Ile, Val, Ala, Arg, Gly, Lys, Asp, Leu, Tyr, Pro, Thr, His, Cys and Met; while tryptophan was analyzed using HPLC method. The five largest amino acids in dark-purple skin and flesh PSP were Glu 565.75 mg/kg, Asp 479.74 mg/kg, Arg 413.54 mg/kg, Ala371.87 mg/kg and Leu 336.67 mg/kg, whereas white flesh and purple skin PSP contained Glu 653.67 mg/kg, Asp 447.60 mg/kg, Arg 314.41 mg/kg, Lys 278.77 mg/kg and Leu 256.97 mg/kg. Future research is needed to investigate the health benefit of amino acids content in PSP from Kawi Mountain cultivar.
Preparation of Nanoparticles from Curcuma longa L. and Cosmos caudatus Extracts
Authors: Putri A S , Octavianty T D , Wahyudi N T , Safitri A 
Published: November 2019

Abstract
This study aims to prepare nanoparticles from Curcuma longa L and Cosmos caudatus extracts, and to investigate their physico-chemical characterizations. The first step in this research was maceration extraction of Curcuma longa L and C. caudatus, using ethanol (96%), and formulated into nanoparticles. Nanoparticles were characterized using spectrophotometry UV-Vis, FTIR spectrometry, and SEM (scanning electron microscopy). UV-Vis spectra confirmed that formation of nanoparticles emerged in the UV-vis region around 420 nm. FTIR analysis revealed the existence of functional flavonoids compounds from the extracts, showing at wavenumber 1440-1420 cm−1. From SEM analysis, the formation of nanoparticles results in mostly flake-like morphology with particles size found within the range of 15-30 nm. The biologically synthesized nanoparticles could be of immense use in medical field for their potential as anti-cancer drugs.
The Effects of Isolate of Goat Casein Yoghurt Milk to MDA Level and Gastric Histopathology of Rats Exposed to 2,3,7,8-Tetrachlorinedibenzo-P-Dioxin (TCDD)
Authors: Mahdi C , Haskito A E P , Robbie M H 
Published: November 2019

Abstract
Dioxins are toxic compounds belonging to organochlorine compounds are highly reactive and produce free radicals that can damage stomach cells. 2,3,7,8-Tetrachlorinedibenzo-p-dioxin (TCDD) is the type of dioxin that has the highest toxicity. Casein goat milk yogurt has the potential as an antioxidant. This study aims to determine the preventive effect of goat milk yoghurt on exposure to dioxin observed levels of malondialdehyde (MDA) and gastric histopathology. Experimental research using Completely Randomized Design (RAL). The white rats (Rattusnorvegicus) were divided into 6 groups, the normal group, casein control (goat milk yoghurt dose 600 mg / kg BW), positive control (TCDD dose 100 ng / kg BW), treatment 1 (goat milk yoghurt 300 mg / kg BW and TCDD 100 ng / kg BW), treatment 2 (goat milk yoghurt 600 mg / kg BW and TCDD 100 ng / kg BW), and treatment 3 (goat milk yoghurt 900 mg / kg BW and TCDD 100 ng / kg BW). Gastric MDA levels were measured using the Thiobarbituric Acid (TBA) assay method with 530 nm wavelength UV-Vis spectrophotometric measurement and gastric histopathology using Hematoxylin-Eosin (HE) staining observed in the form of gastric mucosal cell damage. Gastric MDA levels were analyzed using one way ANOVA statistical test, α = 5% and gastric histopathology analysis were descriptively processed. The results showed that goat milk yoghurt with dose of 600 and 900 mg / kgBW was the best dose in preventing the increase of MDA level of gastric from white rat (Rattusnorvegicus) exposed TCDD significantly (p <0,01), and dose 900mg / kgBB prevented erosion of gastric mucosal cells. The conclusion of this research is giving goat milk goat yoghurt able to prevent the increase of MDA level and erosion of gastric mucosal cells caused by TCDD.
Immunological Responses in Female Rats Model with Anemia Treated with Snake Fruit Seed Flour Extract
Authors: Ristanti I K , Tamtomo D G , Indarto D 
Published: November 2019

AbstractNatural substances become popular for alternative treatment of human diseases including anemia. A recent study has reported that administration of snake fruit seed flour (SSF) is able to increase hemoglobin level in rat model with anemia but it needs higher amount of SSF. In addition, SSF contains 3.71% protein/100g that potentially results in hypersensitivity. The aim of this study was to evaluate the side effects of SSF extract on leucocytes number and its differential account (granulocytes, lymphocytes, and monocytes) in rat model with anemia. We used 14 female rats model with anemia, aged 8-10 weeks, and had ± 200 g body weight (BW). After rats model with iron deficiency anemia (IDA) has been established, female rats were randomly divided into 2 groups: control (C) group only received a low iron diet, and treatment (T) group received a low iron diet and 1.75g/kg BW/day SSF extract for 14 days. Leucocytes number was measured using a veterinary haematology analyzer. Collected data were analyzed using the independent T-test with p value <0.05. Female rats in the C group had the mean leucocytes number higher than the T group, but not statistically different (p=0.073). From differential count, greater numbers of granulocytes and monocytes were observed in the C group, compared to the T group (p=0.301;p=0.34). In contrast to granulocyte and monocytes number, the mean lymphocytes number in the C group were statistically different than the T group (p=0.046). Overall, administration of SSF extract was able to decrease leucocytes number and differential count. Administration of 0.175g/100g BW/day SSF extract does not increase immunological responses in female rats model with anemia.
Construction and Optimization of Prethrombin-2 Human Genes in E. coli for the Production of Active Thrombin
Authors: Silaban S , Gaffar S , Simorangkir M , Maksum I P , Subroto T 
Published: November 2019

Abstract
Prothrombin-2 is a thrombin precursor, which plays an essential role in the conversion of fibrinogen to fibrin during the blood clotting process. In this study, we designed and constructed the human prethrombin-2 (hPT2) gene. hPT2 gene fused with a tag at the n terminal position, which contains the sequence intein followed by chitin binding domain (CBD) that useful for the purification process. The digestion process of hPT2 tag induced by changing its pH/temperature. The hPT2 codon that used in this study designed according to the preference codon of E. coli. hPT2 gene was created using the OPTIMIZER software with the addition of two side restriction at the 5’ and 3’, BamHI and XhoI respectively then were cloned by using the pMAT vector in E. coli. Moreover, hPT2 fragment ligated into an expression vector, pTWIN1, for E. coli. The result from the characterization hPT2 gene in pTWIN1 that using DNA sequencing method shown that the designed hPT2 gene cloned. Thus, the cloned hPT2 gene used as a precursor for PT2 expression in the E. coli host.
Swallow nest extract can be able to prevent nephropathy diabetic of the white rats streptozotocin-induced
Authors: Triawanti T , Alexandra F D , Frethernity A , Mahmud S 
Published: November 2019

Abstract
Hyperglycemia that occurs in diabetic mellitus leads to glycation reactions in protein molecules and oxidative stress resulting in damage to cells and organs. Swallow nest believed society can lower blood glucose. The objective of the study was to analyze the potency of water swallow nest extract to prevent nephrophaty diabetic. The study used Post test-Only with Control Group Design, which consisted of 1 control group (K = aquadest) and 3 treatment groups (nest swallow nest dose 1, 10 and 100 mg / kg BW) each group consisted of 6 Rattus Norvegicius. Before treatment, means of glucose level rats have been 68 mg/DL, then rats were induced Streptozotocin in a dose of 40 mg / kg BW intraperitoneally. Day 7th after induction, rats had elevated glucose ± 102 - 108 mg / dL. Then the rats were given water extract nest swallow white for 28 days orally. All data were analyzed by Kruskall-Wallis test followed by Mann-Whitney test with 95% confidence level. The results of blood glucose levels in each group (K, P1, P2 and P3) were 111.0 vs 88.5 vs 86 vs 83 mg / dL (p = 0.004), pancreas H2O2 levels were 10.16 vs 9.20 vs 8.81 vs 7.27 (p=0,000), serum H2O2 levels were 17.35 vs 16.39 vs 15.01 vs 11.96 (p=0.044), renal methylglioxal levels were 242.55 vs 134.34 vs 67.12 vs 50.48% (p = 0,000) and renal AOPP levels were 1.17 vs 1.09 vs 1.05 vs 1.00 (p=0.000) respectively. The Mann-Whitney test showed a dose of 100 mg / kgBW has the greatest potential. In conclusion the swallow nest water extract has potential as an antidiabetic and prevent of renal’s damage.
Effects of Probiotic Treatment on Histopathology of Koi Carp (Cyprinus carpio) Infected by Myxobolus sp.
Authors: Yanuhar U , Junirahma N S , Susilowati K , Caesar N R , Musa M 
Published: November 2019

Abstract
Koi fish (Cyprinus carpio) is one of the ornamental fish of a high economic value. However, raising koi can be troublesome due to poor water quality and high levels of stress that they are attacked easily by parasites. One of the parasites often attacking the gill of koi is Myxobolus sp. The presence of Myxobolus sp. can be observed through a histopathological observation of gill tissues. The purpose of this study was to determine the histological effect of probiotic administration to the damage on the gill tissue of Koi fish (Cyprinus carpio) infected with Myxobolus sp. The method used in this study was an explorative experimental method using factorial RAL. The observation of gill tissue was carried out on samples of koi fish consisting of two (2) control treatments, namely positive control (K+) and negative control (K-). Then, six (6) treatments, consisting of fish infected with Myxobolus and healthy fish, were done by applying a dose treatment of 1.1 ml/30 litters of water, 0.55 ml/30 litters of water, and 1.65 ml/30 litters of water. Treatments on control groups were carried out in a controlled tank by maintaining water quality parameters, which include temperature, pH, DO, and CO2. The level of gill tissue damage treated with probiotic formulations was determined by scoring analysis. The results of histopathological observations commonly showed tissue damage, namely damage to Edema, Hyperplasia, and Lamela Fusion. The treatment having the best influence according to the 5% BNT test was the PB treatment (infected fish with a dose of probiotic formulation of 0.55 ml/30l).
Molecular docking of the active compound Garcinia mangostana on the RANKL/RANK/OPG system
Authors: Setiawan B , Suhartono E , Kaidah S , Akbar I Z , Noor Z 
Published: November 2019

Abstract
This study aims to analyze the molecular docking between the active compounds of the Garcinia mangostana against the RANKL/RANK/OPG system and its potential as an antiosteoporosis. The research protocol includes the search and modeling of protein and ligand structures and their docking. Software used includes OpenBabel, HEX 8.0, Chimera 1.6.2, Discovery Studio 4.1, LigPlot + and LigandScout 3.1. Tovophillin has the most negative interaction energy with RANKL-OPG (−332.8 Kj/mol) and RANKL-RANK (−298.1 Kj/mol). It was concluded that fourteen active compounds of Garcinia mangostana did not interfere with the physiological function of RANKL against RANK. In addition, the active compound will not affect the RANKL-OPG complex. The antiosteoporosis mechanism of Garcinia mangostana does not by inhibiting RANKL-RANK interactions.
Abdominal Circumference, Body Fat Percent, and VO2 Max in Pilgrims of Hulu Sungai Tengah Regency
Authors: Huldani  , Asnawati  , Auliadina D , Amilia F R , Nuarti N , Jayanti R 
Published: November 2019

Abstract
Maximum oxygen capacity (VO2 max) is the maximum volume of oxygen that the body processes when carrying out intensive activities. VO2 max units is milliliters per minute per kilogram of body weight. Factors that determine VO2 max include age, gender, heart lung function, aerobic muscle metabolism, exercise, genetics, multivitamins, and nutritional status such as BMI, abdominal circumference, and percent body fat. The study is an analytic descriptive. The number of samples is 50 people. Selected using purposive sampling technique. The VO2 max measurement is done by Rockport test. Data analysis uses frequency distribution. The results showed that the majority of the research subjects were 26-45 years old (33%), female (40%), normal BMI (32%), central obesity (44%), normal body fat percent (28%). Data on abdominal circumference relationships and body fat percent with VO2 max were analyzed using the chi square test with a confidence level of 95%, p = 0.04 and p = 0.013. The conclusions of this study were that the majority of Hulu Sungai Tengah pilgrims who had VO2 max enough. There is a significant relationship between abdominal circumference and body fat percent with VO2 max.
Packaging design and determination of shelf life Pundang Seluang
Authors: Harris H , Rochyani N , Widayatsih T 
Published: November 2019

Abstract
Overall, the processed products of South Sumatera fishery products are more varied, both types and shapes, but to compete at the national level, our processed fishery products are still lagging behind in packaging techniques. This study aims to design packaging Pundang Seluang, resulting in packaging Pundang with a more attractive appearance, practical, hygienic, informative and with a longer shelf life. To get the packaging design, used Try and Error method, while for the determination of shelf life used Accelerated Shelf-life Testing (ASLT) method. The results showed that the Selective Parang packed with primary packaging mix (Polypropylene vacuum plastics) and secondary packaging (labeled carton box) provided more attractive, practical, hygienic, and informative protection with longer shelf life, ie with the mathematical model of the rate of increase Water content k = 0,4529.e 0,322 (1 / T) or with rate of quality degradation k = 0,045% per day. Based on the calculation got the age of save Pundang Seluang Packaging for 113,78 days or 3,792 months.
Exploration of natural dyes as alternative substitutes of synthetic dyes on batik making fabrics
Authors: Purwanto P 
Published: November 2019

Abstract
Business batik developing after recognition UNESCO 2009 batik as cultural heritage. World batik summit 2011 in jakarta declare batik industry indonesia should be based on natural protection, environment, and research provision of traditional dye natural. The data from the ministry industry 2015 there is 47.755 unit hpi batik, labor 199.444 people. Suppliers batik 25 % origin Jogja, other Solo and Pekalongan, most wearing dye synthesis, causes pollution of the environment and dangerous. Research objectives the knowledge of the and direction color / different color inflicted a natural dye indigofera, jalawe and higher in with the fixation alum, lime and tunjung. Uses experimental methods making dyes natural material herbs leaves indigofera, bark jalawe and wood higher in. Making the color of indigofera by fermentation, jalawe material and higher in with the process of extracting. The staining with dipped in solution dye, dried and repeating 3 times. Then the process fixation 15 minutes in fiksator alum (70g / l), lime (50g / l) and tunjung (50g / l), and dried in place has direct sunlight. The observation visually and testing different colors wearing spectropothometer uv-vis 2401.The results showed type and the color berbeda-beda, jalawe produces a light brown fixation to after dark brown, high produces a reddish brown discoloration towards dark brown. While indigo produce blue if fixation alum, lime and with tunjung the dark blue. Strong weak color produced depending on the type of nature, the fixation, the number and long immersion cloth.
Framework of sustainable development planning in Indonesia
Authors: Dariah A R , Mafruhat A Y , Hendrakusumah E 
Published: November 2019

Abstract
Indonesia is a country that has a great concern over achievement of SDGs 2030 global agendas. As a big country in terms of population and area, but unfortunately has the most population of lower-middle income, it would be very interesting to examine the process and substance of sustainable development planning in Indonesia. This study uses two methods, i.e., content analysis towards medium-term planning and interview with the planners. Result of Mid-Term Development Plan (RJPMN) 2010-2014, RPJMN 2015-2019 and Action Plan for SDGs Achievement review show that Indonesia applies strategic planning approach as its framework planning of sustainable development which started with the formulation of sustainable development strategic issues, a mission statement, strategies, programs, action plans, targets, and indicators of achievement. This approach has not been reliable yet to address the challenges of interrelated sustainable development. Although the result of interview informs that Indonesian government strives to keep improving the planning process through the increasing involvement and participation of development stakeholders, a paradigm shift is still required to answer all challenges of sustainable development by performing more intensive education.
Problem Based Learning (PBL) as a learning device integrated with Computer Assisted Instruction (CAI) to enhance junior high school students comprehension on the concept of sound
Authors: Aji S D , Hendrayana A D , Hudha M N 
Published: November 2019

Abstract
This research is a research development using 3D models that have been modified from 4D models by Thiagarajan. The aim of this research and development is to describe the developed learning device model that is the Problem Based Learning model integrated with Computer Assisted Instruction to enhance Junior High School students comprehension on the concept of sound. The data are gathered through the interview, filling out the questionnaire about validation of the learning device, physic test on the comprehension of the student, observation on the study process and students responses questionnaire. The test result shows that PBL learning device model integrated with CAI is feasible to be used in the learning process to enhance the students concept comprehension. The finding is based on the fulfillment of the four eligibility criteria such as; (1) Expert validation result and physic teacher for the developing learning device is highly feasible for the learning process; (2) The average percentage on the learning implementation in the test activity is decent; (3) There is an improvement on the concepts comprehension that is showed by the improvement of the average on the comprehension tests result; (4) The students responses are favorable in learning using the learning device PBL model integrated with CAI.
3D modeling the gamelan of saron as a documentation of cultural heritage preservation efforts
Authors: Yuda Y P , Azis M N L 
Published: November 2019

Abstract
"3D modeling the Gamelan of Saron as a Documentation of Cultural Heritage Preservation Efforts" is a research process that aims to preserve the cultural heritage of traditional Javanese musical instruments, Saron. The results of this study are 3D Saron objects. The software used in this study is Blender 3D. In the research process, analysis of the Saron form is then made in 3D software. The research process includes analysis of the shape and layout of 7 taskbars on the gamelan board. By using multimedia developments, it is hoped that it can help preserve the regional cultural heritage. The modeling method used is polygonal modeling, primitive modeling and texturing material. The results of this study can be implemented in the future hopes in other media to form one of the 3D animations.
Anthropometry application of students in the design of campus tables and chairs
Authors: Andriani M 
Published: November 2019

Abstract
The purpose of the research is to design comfortable tables and chairs for learning and gathering students in the campus. The method used is anthropometry and percentiles used to design tables and chairs, statistical tests are used to process anthropometric data and those used are data adequacy tests, data uniformity tests, test data normality with Kolmogorov-Smirnov, Excel software for statistical test calculations, SPSS software for Kolgomorov-Smirnov normality test simulation. The results obtained are the dimensions used by the hand range, elbow height, hand range, popliteal height, popliteal buttocks. Adequacy tests that the data of all dimensions identified are sufficient data, test the uniformity of the data that one data for identified hand span dimensions is not uniform while data for other dimensions are uniform. Kolmogorov-Smirnov normality test for all dimensions data is normally distributed. The conclusion is the table was designed using a percentile of 50% for hand span dimensions, percentile 95% for popliteal height dimensions and sitting elbow height. The chair was designed using percentile 5% for popliteal height dimensions, percentile 50% for hand span dimensions, percentile 95% for popliteal buttocks dimensions.
Generalized Ulam-Hyers Stability of Complex Additive Functional Equation
Authors: Agilan P. , Vallinayagam V. 
Published: November 2019

Abstract
The object of the present paper is to assess speculation of the Hyers-Ulam stability theorem for the complex additive functional equation on abelian groups and stability results have been gotten by a fixed point technique. This technique demonstrates that the stability is identified with some fixed point of an appropriate operator.
Edge Bimagic Labelings of Graphs K2, N, KN, 2, N, Bistar,nC4, and Double Wheel
Authors: Subbulakshmi Dr. S. , Kokila R. 
Published: November 2019

AbstractNgurahet. al. [2010] noted super magic coverings of fans and ladders. Ahmad et. al. [2011] enumerated super edge-magic labeling for the union of non-isomorphic graphs. Lopez et.al. [2012] suggested perfect super edge-magic graphs of path and cycle. Gao and Fan [2013] analyzed super edge-magic labelings of multi-star St(a1,…, an), Ali et. al. [2013] magic Labelings of type (a, b, c) of families of wheels.In this article,edge bimagiclabelings for bipartite complete graph, double bipartite complete graph, bistar merging with a path, one point union of finite copies of cycle having four vertices, and closed double wheel are found.
Flow Shop Scheduling Model for 5machine without Job Block Criteria Using NEH Technique
Authors: Janaki E. , Mohamed Ismail A. 
Published: November 2019

Abstract
The present paper describes no job block criteria using NEH technique in a Flow Shop Scheduling Model for five machines. In flow shop, constraints demand that the jobs passing the machine are same. The probabilities are associated with their respective processing times, in which the optimization criteria is the utilization of 5 machines. For a group of jobs in 5 machines, with no job block and No-wait time is considered in the paper. Our agenda is to reduce the total completion time and the shortest job sequence path using NEH algorithm. Sample numerical illustrations are provided to understand the NEH algorithm easily.