bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-report of domestic violence and forced sex are related to sexual risk behaviors in a sample of juvenile detainees
Authors: Selitsky Lea , Markowitz Norman , Baxa Dwayne M. , Kaljee Linda , Miree Cheryl A. , Islam Nishat , Burse Chez , Newaz Rehnuma , Dankerlui Doreen , Jacobsen Gordon , Joseph Christine 
Published: June 2020

Abstract
Background
Justice-involved youth have higher rates of sexually transmitted infections (STIs), and a higher prevalence of the associated sexual risk behaviors. Sexual risk behaviors are also associated with alcohol and drug use. Research suggests that a history of trauma is an important predictor of alcohol and drug use in youth offenders, and therefore is a likely contributor to sexual risk behavior in this population. The objective of this analysis is to determine the association of trauma, specifically, domestic violence and forced sex, to six sexual risk behaviors and a history of chlamydia among detained youth.

Methods
The analysis uses data from a convenience sample of detainees assenting to HIV testing conducted December 2016 – August 2017 using the state-certified Voluntary Counseling Testing and Referral (VCTR) process.

Results
Of the 379 youth that received VCTR at the facility, 308 (81.3%) were used in this analysis. Report of domestic violence was significantly associated with sex under the influence of alcohol and was also significantly associated with sex under the influence of marijuana. Forced sex was associated with a sexual partner of unknown HIV status.

Conclusions
Traumatic experiences were related to sexual risk behaviors in this analysis, and substance use was strongly implicated in the association. Trauma is known to be a catalyst to sexual risk behaviors, substance use, and delinquency in adolescence. Results support the findings of other investigators and re-iterate the need for trauma-informed interventions that can improve the life trajectories of detained youth.
Early detection of parenting stress in mothers of preterm infants during their first-year home
Authors: Lau C. , Turcich M. R. , Smith E. O. 
Published: June 2020

Abstract
Background
Maternal stress following the birth of an infant is well acknowledged. It is particularly so when infants are born prematurely as their mothers cannot fully take on their parenting role until their infant(s) is discharged from neonatal intensive care units (NICUs). In this exploratory study, we examined whether these mothers’ parenting stress would lessen during their first-year reunification with their infant(s) as they settle into motherhood at home.

Methods
Two groups of mothers with infants born between 24- and 33-week gestational age were recruited. A group of 25 mothers were monitored at their infants’ 1-month corrected age (CA) and a second group of 24 mothers were monitored at their infants’ 12-month CA. Subjects completed the long form Parental Stress Index (PSI) ranking how stressful they perceive the individual subscales in the Child and Parent Domains of the self-reported questionnaire (PSI-3; Abidin; PAR Inc). The PSI theorizes that the stress mothers perceive is a resultant of their respective characteristics, interactions with their infant(s), family, and environment. Statistical analyses include descriptive statistics, χ2 square analysis, and independent t-test.

Results
There was no significant difference in the levels of perceived stress in the PSI subscales between the two groups of mothers at 1- and 12-month CA. Scores for the majority of respondents fell within the 15th to 80th percentile (% ile) distribution of Abidin’s normative population, with some mothers falling below the 15th % ile.

Discussion/conclusion
The data collected suggest that: 1. the perceived stress experienced by mothers during their first-year reunited with their preterm infants is within the normal range observed in Abidin’s normative population. 2. As the PSI is a self-reported survey, care providers need to be aware that some mothers may downplay their stress responses. 3. With the ability to monitor individual participants, the PSI can be readily offered to mothers at their infants’ first year routine clinical visits to assist in the early identification of parenting issues that may threaten the development of a healthy mother-infant dyad. Early appropriate guidance and social support would help “at-risk” mothers develop more constructive parenting routines.
Natural dietary compound naringin inhibits glioblastoma cancer neoangiogenesis
Authors: Aroui Sonia , Fetoui Hamadi , Kenani Abderraouf 
Published: June 2020

AbstractBackgroundFlavonoids, which existed nearly in all fruits and vegetables, are considered as a class of plant-secondary metabolites with a polyphenolic structure and have properties with health-improving potential. Yet, not so many experimental focus on the benefits of flavonoid in vivo after external application. Here we assessed the impacts of naringin in vitro and in vivo in the human glioma U-87 cells implanted into athymic mice.MethodsTumor size and animal survival time were followed in naringin-treated mice bearing subcutaneous gliomas. To define the effects of naringin on angiogenesis, in vitro, tube formation and migration were assayed using endothelial HUVEC cell line.ResultsLow concentration of naringin remarkably inhibited tubulogenesis and reduced cell invasion. Moreover, naringin has been shown to have a toxicity effect on U-87 cells in a dose-dependent way. Furthermore, naringin administration (120 mg/kg/day) applies serious anti-cancer belongings on glioblastoma, as demonstrated by a slow cancer progression.ConclusionsOur study has provided the first evidence on the antitumor effect of naringin, which is somehow due to the inhibition of invasion and angiogenesis.
Comparing community birdwatching and professional bird monitoring with implications for avian diversity research: a case study of Suzhou, China
Authors: Zhou Yan , Chen Anping , Ouyang Jenny Q. , Liu Yanlin , Zheng Aiyu , Yang Zaixi , Zhang Yong , Wang Bin , Jia Yifei , Jiao Shengwu , Zeng Qing , Lu Changhu 
Published: June 2020

Abstract
Background
In the past decades, birdwatching as a hobby developed rapidly and produced ample scientific records that have aided conservation efforts. Therefore, it is increasingly attractive to promote avian research by providing data from birdwatching.

Methods
We compared records from 16 years of community birdwatching and a 1-year formalized bird monitoring in Suzhou, China to study the similarities and differences between the two monitoring methods.

Results
We showed that within the 325 bird species recorded by the two methods, an annual average of 108 species were documented by community science and 223 bird species were recorded by 1-year formalized monitoring. Measured by the number of bird species recorded per survey trip, the bird monitoring activity of community birdwatchers was significantly lower. Furthermore, the monitoring intensity of community birdwatching measured as the average survey trips per site each survey year was also lower than that of formalized bird monitoring. In addition, community birdwatchers preferred urban landscapes to rural areas.

Conclusions
Community birdwatching could record the majority of local birds and complements the professional surveys in avian research. Well designed and coordinated community science can be used to expand the knowledge about avian distribution and population dynamics. These findings are critical for the development of conservation science with regard to community involvement.
Correction of malocclusion using sliding fibula osteotomy with sagittal split ramus osteotomy after mandible reconstruction
Authors: Lee Dong-Hun , Kim Seong Ryoung , Jang Sam , Ahn Kang-Min , Lee Jee-Ho 
Published: June 2020

Abstract
Background
Fibula free flap mandible reconstruction is the standard procedure after wide resection of the mandible. Establishment and maintenance of normal occlusion are important in mandible reconstruction both intraoperatively and after surgery. However, scar formation on the surgical site can cause severe fibrosis and atrophy of soft tissue in the head and neck region.

Case presentation
Here, we report a case of severe soft tissue atrophy that appeared along with scar formation after mandibular reconstruction through the fibular free flap procedure. This led to normal occlusion collapse after it was established, and the midline of the mandible became severely deviated to the affected side that was replaced with the fibula free flap, leading to facial asymmetry. We corrected the malocclusion with a secondary operation: a sagittal split ramus osteotomy on the unaffected side and a sliding osteotomy on the previous fibula graft. After a healing time of 3 months, implants were placed on the fibula graft for additional occlusal stability.

Conclusion
We report satisfactory results from the correction of malocclusion after fibula reconstruction using sliding fibula osteotomy and sagittal split ramus osteotomy. The midline of the mandible returned to its original position and the degree of facial asymmetry was reduced. The implants reduced difficulties that the patient experienced with masticatory function.
Work stress and sleep disturbances among internship nursing students
Authors: Rabei Samah , Mourad Ghada , Hamed Alaa El Din 
Published: June 2020

AbstractBackgroundNurses are one of the most vulnerable professional groups to occupational stress and sleep problem. A relation between occupational stress and sleep problem is suggested and needs to be investigated. The aim of this descriptive study is designed to assess work stress and sleep disturbances among internship nursing students and the relation between them.ResultsA total of 95 nursing internship students were subjected to Pittsburgh Sleep Quality Index (PSQI) and Expanded Nursing Stress Scale (ENSS). The greater the number of patients a nurse cares for, the greater the nursing stress. Greater number and duration of shifts worsen sleep. Problems related to peers worsen sleep quality. Demanding patients and their families lessen the actual sleep duration of nurses. Demanding patients and their families, work load, discrimination, and uncertainty regarding treatment lessen the habitual sleep efficiency of nurses.ConclusionNurses with higher workload experience more sleep disturbances.
Type VI Choledochal Cyst; A Case Report and Review of the Literature
Authors: Aslan Serdar , Görgel Ömer , Çakır İsmet Miraç 
Published: June 2020

Abstract
Background
Choledochal or common bile duct (CBD) cysts are congenital cystic dilatation of any part of the bile ducts. It has been classified into five main types by Todani et al. Isolated cystic duct cysts are not included in this classification. It is extremely rare, and there are a limited number of cases in the literature.

Case presentation
A 34-year-old male patient was admitted to our hospital with right upper quadrant (RUQ) pain experienced intermittently for the past year. His medical history and laboratory findings were normal. Physical examination revealed tenderness in the RUQ. Abdominal ultrasonography shows that a thin, tubular, cystic lesion was associated with the CBD. On magnetic resonance imaging (MRI) and magnetic resonance cholangiopancreatography (MRCP), a saccular dilatation was observed in the middle part of the cystic duct. Isolated cystic duct dilatation was considered with current imaging findings. Laparoscopic cholecystectomy and cyst excision were performed. Surgery findings and histopathological examination of the excised cyst confirmed the diagnosis.

Conclusion
Isolated dilatations of the cystic duct are extremely rare, and familiarity with this anatomic variation and its early diagnosis can prevent complications such as inflammation and malignancy and guide the surgery. The most effective noninvasive imaging method in diagnosis is MRCP. Also, we recommend that it be classified as a new type with the name type VI biliary cyst, in addition to Todani classification.
Randomized Trial Comparing Double Versus Triple Bortezomib-Based Regimen in Patients With Multiple Myeloma and Acute Kidney Injury Due to Cast Nephropathy
Authors: Bridoux Frank , Arnulf Bertrand , Karlin Lionel , Blin Nicolas , Rabot Nolwenn , Macro Margaret , Audard Vincent , Belhadj Karim , Pegourie Brigitte , Gobert Pierre , Cornec Le Gall Emilie , Joly Bertrand , Karras Alexandre , Jaccard Arnaud , Augeul-Meunier Karine , Manier Salomon , Royer Bruno , Caillot Denis , Tiab Mourad , Delbes Sébastien , Suarez Felipe , Vigneau Cécile , Caillard Sophie , Arakelyan-Laboure Nina , Roos-Weil Damien , Chevret Sylvie , Fermand Jean Paul ,   for the MYRE study group
Published: June 2020

PURPOSE We report a multicenter controlled trial comparing renal recovery and tolerance profile of doublet versus triplet bortezomib-based regimens in patients with initial myeloma cast nephropathy (CN) and acute kidney injury (AKI) without need for dialysis. METHODS After symptomatic measures and high-dose dexamethasone, patients were randomly assigned to receive bortezomib plus dexamethasone (BD), or BD plus cyclophosphamide (C-BD). In patients with < 50% reduction of serum free light chains (sFLCs) after 3 cycles, chemotherapy was reinforced with either cyclophosphamide (BD group) or thalidomide (C-BD group). RESULTS Ninety-two patients were enrolled in each group. At random assignment, characteristics of the 2 groups were similar, including median age (68 years) and serum creatinine level (305.5 and 273.5 µmol/L in BD and C-BD group, respectively). At 3 months, renal response rate (primary end point) was not different (41 v 47 responders in the BD and C-BD groups, respectively; relative risk [RR], 0.87; P = .46). Very good partial response (free light chain reduction ≥ 90%) or more was achieved in 36 and 47 patients, respectively (RR, 0.76; P = .10). After 1 cycle of chemotherapy, 69 in the BD group and 67 patients in the C-BD group had achieved sFLC level ≤ 500 mg/L. Serious adverse events were recorded in 30 and 40 patients, respectively. At 12 months, 19 patients had died (9 in the BD group v 10 in the C-BD group), including 10 (6 in the BD group and 4 in the C-BD group) from myeloma progression and 3 (0 in the BD group and 3 in the C-BD group) from infection. Within median follow-up of 27 months, 43 and 42 patients switched to new therapy, respectively. Overall, 50 patients (24 in the BD group and 26 in the C-BD group) had died. CONCLUSION This randomized study did not show any benefit of C-BD compared with BD on renal recovery of patients with initial CN not requiring dialysis. Adding cyclophosphamide did not sufficiently improve the efficacy-toxicity balance. Patients with myeloma with AKI are fragile, and indication for doublet or triplet regimen should be adapted to frailty.
Nurse-Led Vital Signs Monitoring Can Safely Identify Low-Risk Hematology-Oncology Patients For De-Escalation
Authors: Tham Sai Meng , Kasinathan Sharmilla , Lui Pak Ling , Lim Bee Kuan , Yap Rose Anne Pepito , Montanez Felma Bacabac , Ow Samuel G. W. 
Published: June 2020

PURPOSE: It is routine practice for patients to be on vital signs monitoring (VSM) once every 4 hours, which is laborious and disruptive. VSM de-escalation has been demonstrated to be safe in low-risk (LR) patients, but it has not been well studied in the hematology-oncology setting. METHODS: A quality improvement project was conducted in 3 hematology-oncology inpatient wards within a comprehensive cancer center, from March 2017 to July 2017 (pilot phase) and from October 2017 to Sept 2018 (maintenance phase). Root causes for frequent VSM identified via problem analysis include (1) perception of VSM, (2) lack of concise clinical guidelines, and (3) lack of nurse empowerment. Consensus criteria to define suitable LR patients and a nurse-led VSM de-escalation protocol were formulated. RESULTS: Of 1,065 patients who underwent nurse-led VSM de-escalation, there was a 50% reduction in the mean number of nurse encounters (NE) per month ( P < .01), with total savings of 2,731.5 NE-minutes per month. VSM re-escalation was required by 10.1% of patients; all were deemed unpreventable with more frequent VSM and none resulted in severe adverse outcomes. With additional interventions such as spot audits and retraining, recruitment for de-escalation improved from 51.7% of LR admissions in the pilot phase to 93.8% in the maintenance phase ( P < .01). The time saved was used to enhance other aspects of patient care, such as patient education. One hundred thirty-nine of 169 doctors and nurses surveyed after implementation (96.5%) supported continuing this protocol. CONCLUSION: A well-defined protocol allows safe nurse-led de-escalation of VSM for LR patients without adverse outcomes and was shown to be sustainable in this cohort of hematology-oncology patients.
Anogenital Distance in Healthy Infants: Method-, Age- and Sex-related Reference Ranges
Authors: Fischer Margit Bistrup , Ljubicic Marie Lindhardt , Hagen Casper P , Thankamony Ajay , Ong Ken , Hughes Ieuan , Jensen Tina Kold , Main Katharina M , Petersen Jørgen Holm , Busch Alexander S , Upners Emmie N , Sathyanarayana Sheela , Swan Shanna H , Juul Anders 
Published: June 2020

Abstract

Context
The use of anogenital distance (AGD) in clinical and epidemiological settings is increasing; however, sex-specific reference data on AGD and data on longitudinal changes in AGD in children is scarce.

Objective
To create age-, sex-, and method-related reference ranges of AGD in healthy boys and girls aged 0–24 months, to assess the age-related changes in AGD and to evaluate the 2 predominantly used methods of AGD measurement.

Design
The International AGD consortium comprising 4 centers compiled data from 1 cross-sectional and 3 longitudinal cohort studies (clinicaltrials.gov [NCT02497209]).

Setting
All data were collected from population-based studies, recruiting from 4 maternity or obstetric centers (United States, Cambridge [United Kingdom], Odense, and Copenhagen [Denmark]).

Subjects
This study included a total of 3705 healthy, mainly Caucasian children aged 0–24 months on whom 7295 measurements were recorded.

Main Outcome Measures
AGDAS (ano-scrotal), AGDAF (ano-fourchette), AGDAP (ano-penile), AGDAC (ano-clitoral), AGD body size indices (weight, body mass index [BMI], body surface area, and length), and intra- and interobserver biases.

Results
We created age-specific reference ranges by centers. We found that AGD increased from birth to 6 months of age and thereafter reached a plateau. Changes in AGD/BMI during the first year of life were minor (0–6% and 0–11% in boys and girls, respectively).

Conclusions
Reference ranges for AGD can be used in future epidemiological research and may be utilized clinically to evaluate prenatal androgen action in differences-in-sex-development patients. The increase in AGD during the first year of life was age-related, while AGD/BMI was fairly stable. The TIDES and Cambridge methods were equally reproducible.
Pain in Patients With Type 2 Diabetes-Related Polyneuropathy Is Associated With Vascular Events and Mortality
Authors: Lapin Brittany R , Pantalone Kevin M , Milinovich Alex , Morrison Shannon , Schuster Andrew , Boulos Fernanda , Johnson Kristen , Thakore Nimish J 
Published: June 2020

Abstract

Purpose
Type 2 diabetes–related polyneuropathy (DPN) is associated with increased vascular events and mortality, but determinants and outcomes of pain in DPN are poorly understood. We sought to examine the effect of neuropathic pain on vascular events and mortality in patients without DPN, DPN with pain (DPN + P), and DPN without pain (DPN-P).

Methods
A retrospective cohort study was conducted within a large health system of adult patients with type 2 diabetes from January 1, 2009 through December 31, 2016. Using an electronic algorithm, patients were classified as no DPN, DPN + P, or DPN-P. Primary outcomes included number of vascular events and time to mortality. Independent associations with DPN + P were evaluated using multivariable negative binomial and Cox proportional hazards regression models, adjusting for demographics, socioeconomic characteristics, and comorbidities.

Results
Of 43 945 patients with type 2 diabetes (age 64.6 ± 14.0 years; 52.1% female), 13 910 (31.7%) had DPN: 9104 DPN + P (65.4%) vs 4806 DPN-P (34.6%). Vascular events occurred in 4538 (15.1%) of no DPN patients, 2401 (26.4%) DPN + P, and 1006 (20.9%) DPN-P. After adjustment, DPN + P remained a significant predictor of number of vascular events (incidence rate ratio [IRR] = 1.55, 95% CI, 1.29-1.85), whereas no DPN was protective (IRR = 0.70, 95% CI, 0.60-0.82), as compared to DPN-P. Compared to DPN-P, DPN + P was also a significant predictor of mortality (hazard ratio = 1.42, 95% CI, 1.25-1.61).

Conclusions
Our study found a significant association between pain in DPN and an increased risk of vascular events and mortality. This observation warrants longitudinal study of the risk factors and natural history of pain in DPN.
H3K9me3 maintenance on a human artificial chromosome is required for segregation but not centromere epigenetic memory
Authors: Martins Nuno M. C. , Cisneros-Soberanis Fernanda , Pesenti Elisa , Kochanova Natalia Y. , Shang Wei-Hao , Hori Tetsuya , Nagase Takahiro , Kimura Hiroshi , Larionov Vladimir , Masumoto Hiroshi , Fukagawa Tatsuo , Earnshaw William C. 
Published: June 2020

ABSTRACT
Most eukaryotic centromeres are located within heterochromatic regions. Paradoxically, heterochromatin can also antagonize de novo centromere formation, and some centromeres lack it altogether. In order to investigate the importance of heterochromatin at centromeres, we used epigenetic engineering of a synthetic alphoidtetO human artificial chromosome (HAC), to which chimeric proteins can be targeted. By tethering the JMJD2D demethylase (also known as KDM4D), we removed heterochromatin mark H3K9me3 (histone 3 lysine 9 trimethylation) specifically from the HAC centromere. This caused no short-term defects, but long-term tethering reduced HAC centromere protein levels and triggered HAC mis-segregation. However, centromeric CENP-A was maintained at a reduced level. Furthermore, HAC centromere function was compatible with an alternative low-H3K9me3, high-H3K27me3 chromatin signature, as long as residual levels of H3K9me3 remained. When JMJD2D was released from the HAC, H3K9me3 levels recovered over several days back to initial levels along with CENP-A and CENP-C centromere levels, and mitotic segregation fidelity. Our results suggest that a minimal level of heterochromatin is required to stabilize mitotic centromere function but not for maintaining centromere epigenetic memory, and that a homeostatic pathway maintains heterochromatin at centromeres.
This article has an associated First Person interview with the first authors of the paper.