bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engaging youths in skill development through network system wiring workshop in rural area
Authors: Mad Kaidi Hazilah , Ahmad Norulhusna , Mohd Hashim Nor Fazilah , Salim Fatimah , Muhtazaruddin Mohd Nabil , Bani Nurul Aini , Mohamed Norliza , Musa Rafizah , Mohd Aris Siti Armiza , A Jalil Siti Zura 
Published: March 2020

<span>Nowadays, youths underuse their time, energy and creativity in a vast number of other activities, which lead to almost nothing in return. Thus, to fully utilise their huge potential of skills and abilities is by offering productive ways to attract young people in educational-related activities. This paper is presenting the community project on the network wiring system workshop that has been conducted for the young generation at Kg. Serting Ulu, Simpang Pertang Jempol, Negeri Sembilan, Malaysia. The aim of participating in this project is to deliver the knowledge base and develop skills in technology and engineering. In addition, it is also intended to develop interpersonal skills, communication and lifelong learning as well as to increase the ability of a young generation to generate a side income by venturing into entrepreneurship field. Participants in this network system wiring workshop were exposed to a multitude of basic installation and wiring techniques in which they were able to shape their personalities with the advantage of acquired technology and engineering skills. As a result, the return on investment (RoI) and social return on investment (SRoI) targets for the workshop can be achieved. It was conducted at a rural area named as Kampung Serting Ulu, Simpang Pertang Jempol, Negeri Sembilan, Malaysia. </span>
Academician perceptions towards online student evaluation
Authors: Mohd Ariffin Nor Hapiza , Hidayah Askol Siti Nor 
Published: March 2020

<p>In higher education institutions, student evaluation is important to ensure that students are given the opportunity to attain a high quality of education. In Universiti Teknologi Mara (UiTM) Malaysia, student evaluation was implemented through a system called Student Feedback Online (SuFO). This study aims to investigate and analyze the perception of academicians towards the usage of online student evaluation using SUFO in UiTM. The research employed the quantitative analysis and supported by Rasch measurement. The respondents are academicians in UiTM Shah Alam. A total of 152 academicians responded to the questionnaires. By using a Likert scale, 25 items were designed in the questionnaire and distributed by official email to the academicians. Data were analyzed using Rasch measurement to measure the validity and reliability of the items and the respondents involved in this research, while SPSS was used to analyze the quantitative data. The results showed that the academicians accepted the outcome value of student evaluation and they agreed that results of student evaluation should be used for formative assessment. It is recommended for future research, an instrument using a method of multi-dimensional evaluation of teaching should be developed to evaluate the effectiveness of university teaching.</p>
Classification neutral to ground (NG) voltage using levenberg-marquardt neural network (LMNN)
Authors: Kamaruddin Suzaryfazli , Abidin Ahmad Farid , Yusoh Mohd Abdul Talib Mat 
Published: March 2020

<span>In electrical systems nowadays, power quality issues have become a major concern for customers and electrical utilities. The high Neutral to ground (NG) voltage are one of the power quality issues which could cause adverse effect such as malfunction the devices, neutral overheating and electricity shock. Thus, the high NG voltage should be classified in order to perform the mitigation work accurately. This paper presents the classification of neutral to ground voltage using Levenberg-Marquardt Neural Network (LMNN) technique. The Discrete Wavelet Transform (DWT) is applied in this method to extract the features of NG voltage which needed in classification process. The result shows the LMNN perform accurately in classify the types of NG voltage, where its accuracy result is reach more than 90% accuracy.</span>
Evaluation of proposed amalgamated anonymization approach
Authors: Narula Deepak , Kumar Pardeep , Upadhyaya Shuchita 
Published: March 2020

<p>In the current scenario of modern era, providing security to an individual is always a matter of concern when a huge volume of electronic data is gathering daily. Now providing security to the gathered data is not only a matter of concern but also remains a notable topic of research. The concept of Privacy Preserving Data Publishing (PPDP) defines accessing the published data without disclosing the non required information about an individual. Hence PPDP faces the problem of publishing useful data while keeping the privacy about sensitive information about an individual. A variety of techniques for anonymization has been found in literature, but suffers from different kind of problems in terms of data information loss, discernibility and average equivalence class size. This paper proposes amalgamated approach along with its verification with respect to information loss, value of discernibility and the value of average equivalence class size metric. The result have been found encouraging as compared to existing <em>k-</em>anonymity based algorithms such as Datafly, Mondrian and Incognito on various publically available datasets.</p>
Real-World Adherence and Persistence to Direct Oral Anticoagulants in Patients With Atrial Fibrillation
Authors: Ozaki Aya F. , Choi Austin S. , Le Quan T. , Ko Dennis T. , Han Janet K. , Park Sandy S. , Jackevicius Cynthia A. 
Published: March 2020

Background:
Stroke reduction with direct oral anticoagulants (DOACs) in atrial fibrillation (AF) is dependent on adherence and persistence in the real-world setting. Individual study estimates of DOAC adherence/persistence rates have been discordant. Our aims were to characterize real-world observational evidence for DOAC adherence/persistence and evaluate associated clinical outcomes in patients with AF.

Methods and Results:
PubMed, EMBASE, and CINAHL were searched from inception to June 2018. Observational studies that reported real-world DOAC adherence/persistence in patients with AF were included. Study quality was assessed using the Newcastle-Ottawa Scale. Meta-analyses for pooled estimates were performed using DerSimonian and Laird random-effects models. Outcomes included DOAC mean proportion of days covered or medication possession ratio, proportion of good adherence (proportion of days covered/medication possession ratio ≥80%), persistence, DOAC versus vitamin K antagonists persistence, and clinical outcomes associated with nonadherence/nonpersistence. Forty-eight observational studies with 594 784 unique patients with AF (59% male; mean age 71 years) were included. The overall pooled mean proportion of days covered/medication possession ratio was 77% (95% CI, 75%–80%), proportion of patients with good adherence was 66% (95% CI, 63%–70%), and proportion persistent was 69% (95% CI, 65%–72%). The pooled proportion of patients with good adherence was 71% (95% CI, 64%–78%) for apixaban, 60% (95% CI, 52%–68%) for dabigatran, and 70% (95% CI, 64%–75%) for rivaroxaban. Similar patterns were found for pooled persistence by agent. The pooled persistence was higher with DOACs than vitamin K antagonists (odds ratio, 1.44 [95% CI, 1.12–.86]). DOAC nonadherence was associated with an increased risk of stroke (hazard ratio, 1.39 [95% CI, 1.06–1.81]).

Conclusions:
Suboptimal adherence and persistence to DOACs was common in patients with AF, with 1 in 3 patients adhering to their DOAC <80% of the time, which was associated with poor clinical outcomes in nonadherent patients. Although it is convenient that DOACs do not require laboratory monitoring, greater effort in monitoring for and interventions to prevent nonadherence may be necessary to optimize stroke prevention. Increased clinician awareness of DOAC nonadherence may help identify at-risk patients.
Association Between Road Traffic Noise and Incidence of Diabetes Mellitus and Hypertension in Toronto, Canada: A Population‐Based Cohort Study
Authors: Shin Saeha , Bai Li , Oiamo Tor H. , Burnett Richard T. , Weichenthal Scott , Jerrett Michael , Kwong Jeffrey C. , Goldberg Mark S. , Copes Ray , Kopp Alexander , Chen Hong 
Published: March 2020

Background
Exposure to road traffic noise has been linked to cardiometabolic complications, such as elevated blood pressure and glucose dysregulation. However, epidemiologic evidence linking road traffic noise to diabetes mellitus and hypertension remains scarce. We examined associations between road traffic noise and the incidence of diabetes mellitus and hypertension in Toronto, Canada.

Methods and Results

Using the Ontario Population Health and Environment Cohort, we conducted a retrospective, population‐based cohort study of long‐term residents of Toronto, aged 35 to 100 years, who were registered for provincial publicly funded health insurance, and were without a history of hypertension (n=701 174) or diabetes mellitus (n=914 607). Road traffic noise exposure levels were assessed by the equivalent continuous A‐weighted sound pressure level (dBA) for the 24‐hour day and the equivalent continuous A‐weighted sound pressure level for the night (11
pm
–7
am)
. Noise exposures were assigned to subjects according to their annual residential postal codes during the 15‐year follow‐up. We used random‐effect Cox proportional hazards models adjusting for personal and area‐level characteristics. From 2001 to 2015, each interquartile range increase in the equivalent continuous A‐weighted sound pressure level (dBA) for the 24‐hour day (10.0 dBA) was associated with an 8% increase in incident diabetes mellitus (95% CI, 1.07–1.09) and a 2% increase in hypertension (95% CI, 1.01–1.03). We obtained similar estimates with the equivalent continuous A‐weighted sound pressure level for the night (11
pm
–7
am)
. These results were robust to all sensitivity analyses conducted, including further adjusting for traffic‐related air pollutants (ultrafine particles and nitrogen dioxide). For both hypertension and diabetes mellitus, we observed stronger associations with the equivalent continuous A‐weighted sound pressure level (dBA) for the 24‐hour day among women and younger adults (aged <60 years).

Conclusions
Long‐term exposure to road traffic noise was associated with an increased incidence of diabetes mellitus and hypertension in Toronto.
Differentiating Experience From Cue Utilization in Radiological Assessments
Authors: Carrigan Ann J. , Magnussen John , Georgiou Andrew , Curby Kim M. , Palmeri Thomas J. , Wiggins Mark W. 
Published: March 2020

Objective This research was designed to examine the contribution of self-reported experience and cue utilization to diagnostic accuracy in the context of radiology. Background Within radiology, it is unclear how task-related experience contributes to the acquisition of associations between features with events in memory, or cues, and how they contribute to diagnostic performance. Method Data were collected from 18 trainees and 41 radiologists. The participants completed a radiology edition of the established cue utilization assessment tool EXPERTise 2.0, which provides a measure of cue utilization based on performance on a number of domain-specific tasks. The participants also completed a separate image interpretation task as an independent measure of diagnostic performance. Results Consistent with previous research, a k-means cluster analysis using the data from EXPERTise 2.0 delineated two groups, the pattern of centroids of which reflected higher and lower cue utilization. Controlling for years of experience, participants with higher cue utilization were more accurate on the image interpretation task compared to participants who demonstrated relatively lower cue utilization ( p = .01). Conclusion This study provides support for the role of cue utilization in assessments of radiology images among qualified radiologists. Importantly, it also demonstrates that cue utilization and self-reported years of experience as a radiologist make independent contributions to performance on the radiological diagnostic task. Application Task-related experience, including training, needs to be structured to ensure that learners have the opportunity to acquire feature–event relationships and internalize these associations in the form of cues in memory.
The application of RNA sequencing for the diagnosis and genomic classification of pediatric acute lymphoblastic leukemia
Authors: Brown Lauren M. , Lonsdale Andrew , Zhu Andrea , Davidson Nadia M. , Schmidt Breon , Hawkins Anthony , Wallach Elise , Martin Michelle , Mechinaud Francoise M. , Khaw Seong Lin , Bartolo Ray C. , Ludlow Louise E. A. , Challis Jackie , Brooks Ian , Petrovic Vida , Venn Nicola C. , Sutton Rosemary , Majewski Ian J. , Oshlack Alicia , Ekert Paul G. 
Published: March 2020

Abstract
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, and implementation of risk-adapted therapy has been instrumental in the dramatic improvements in clinical outcomes. A key to risk-adapted therapies includes the identification of genomic features of individual tumors, including chromosome number (for hyper- and hypodiploidy) and gene fusions, notably ETV6-RUNX1, TCF3-PBX1, and BCR-ABL1 in B-cell ALL (B-ALL). RNA-sequencing (RNA-seq) of large ALL cohorts has expanded the number of recurrent gene fusions recognized as drivers in ALL, and identification of these new entities will contribute to refining ALL risk stratification. We used RNA-seq on 126 ALL patients from our clinical service to test the utility of including RNA-seq in standard-of-care diagnostic pipelines to detect gene rearrangements and IKZF1 deletions. RNA-seq identified 86% of rearrangements detected by standard-of-care diagnostics. KMT2A (MLL) rearrangements, although usually identified, were the most commonly missed by RNA-seq as a result of low expression. RNA-seq identified rearrangements that were not detected by standard-of-care testing in 9 patients. These were found in patients who were not classifiable using standard molecular assessment. We developed an approach to detect the most common IKZF1 deletion from RNA-seq data and validated this using an RQ-PCR assay. We applied an expression classifier to identify Philadelphia chromosome–like B-ALL patients. T-ALL proved a rich source of novel gene fusions, which have clinical implications or provide insights into disease biology. Our experience shows that RNA-seq can be implemented within an individual clinical service to enhance the current molecular diagnostic risk classification of ALL.
A novel C2 domain binding CD33xCD3 bispecific antibody with potent T-cell redirection activity against acute myeloid leukemia
Authors: Nair-Gupta Priyanka , Diem Michael , Reeves Dara , Wang Weirong , Schulingkamp Robert , Sproesser Katrin , Mattson Bethany , Heidrich Bradley , Mendonça Mark , Joseph Jocelin , Sendecki Jocelyn , Foulk Brad , Chu Gerald , Fink Damien , Jiao Qun , Wu Sheng-Jiun , Packman Kathryn , Elsayed Yusri , Attar Ricardo , Gaudet François 
Published: March 2020

Abstract
CD33 is expressed in 90% of patients with acute myeloid leukemia (AML), and its extracellular portion consists of a V domain and a C2 domain. A recent study showed that a single nucleotide polymorphism (SNP), rs12459419 (C &gt; T), results in the reduced expression of V domain–containing CD33 and limited efficacy of V domain–binding anti-CD33 antibodies. We developed JNJ-67571244, a novel human bispecific antibody capable of binding to the C2 domain of CD33 and to CD3, to induce T-cell recruitment and CD33+ tumor cell cytotoxicity independently of their SNP genotype status. JNJ-67571244 specifically binds to CD33-expressing target cells and induces cytotoxicity of CD33+ AML cell lines in vitro along with T-cell activation and cytokine release. JNJ-67571244 also exhibited statistically significant antitumor activity in vivo in established disseminated and subcutaneous mouse models of human AML. Furthermore, this antibody depletes CD33+ blasts in AML patient blood samples with concurrent T-cell activation. JNJ-67571244 also cross-reacts with cynomolgus monkey CD33 and CD3, and dosing of JNJ-67571244 in cynomolgus monkeys resulted in T-cell activation, transient cytokine release, and sustained reduction in CD33+ leukocyte populations. JNJ-67571244 was well tolerated in cynomolgus monkeys up to 30 mg/kg. Lastly, JNJ-67571244 mediated efficient cytotoxicity of cell lines and primary samples regardless of their SNP genotype status, suggesting a potential therapeutic benefit over other V-binding antibodies. JNJ-67571244 is currently in phase 1 clinical trials in patients with relapsed/refractory AML and high-risk myelodysplastic syndrome.
Prevalence and risk factors for khat use among youth students in Ethiopia: systematic review and meta-analysis, 2018
Authors: Alemu Wondale Getinet , Zeleke Tadele Amare , Takele Wubet Worku , Mekonnen Shegaye Shumet 
Published: March 2020

Abstract
Background
Khat use is a widely spreading public health problem affecting the most economically productive population areas in Ethiopia. Khat use among students has been linked with mental, physical, social, and psychological problems. Reliable prevalence has not been recognized because of varying published rates. The objective of this systematic review and meta-analysis is to synthesize evidence on the prevalence and potential risk factors of khat use in Ethiopia.

Methods
We found 284 studies of which 266 were removed due to duplication, irrelevant topics, and other reasons, respectively. All studies conducted in Ethiopia on khat chewing among students irrespective of time frame were included. Subsequently, 18 studies were used for synthesis of prevalence. Figures were extracted from published reports, and any lost information was requested from investigators. The quality of the included literature was evaluated by using the Newcastle–Ottawa Scale (NOS). Prevalence was pooled using random-effects meta-analyses. The presence of association was declared using P-values and an odds ratio with a corresponding 95% CI.

Results
The pooled prevalence of khat use among students was 16.7% (13.7–19.7%). In the subgroup analysis, the highest prevalence was observed in the Oromia region, at 21.1% (15.5%, 26.7%), and an almost equal prevalence of 14.8% (10.6, 18.9) and 14.3% (10.3, 18.3) was observed in Amhara and the Southern Nation, Nationalities, and People’s Region of Ethiopia, respectively. Being male (OR: 2.43 (1.73, 3.13)), being a Muslim religion follower (OR: 2.22 (1.6, 2.8)), being an alcohol user (OR: 2.3 (1.5, 3.0)), khat use by a family member (OR: 1.8 (1.4, 2.2)), peer pressure (OR: 4.4 (3.1, 5.6)), and being a cigarette smoker (OR: 8.5 (5.3, 11.7)) were found to be risk factors for khat chewing.

Conclusions
Khat use is a common problem among students. Health promotion, awareness on effect of khat, set policy on khat and substance use on the male sex, Muslim religion, alcohol user, having a family-member khat user, peer pressure, and being a cigarette smoker as possible risk factors for khat use among students.

Limitations
Irrespective of time restriction, all studies conducted in Ethiopia are included and cross-sectional in nature. Protocol no. CRD-42017081886.
Personalized cognitive-behavioural therapy for obesity (CBT-OB): theory, strategies and procedures
Authors: Dalle Grave Riccardo , Sartirana Massimiliano , Calugi Simona 
Published: March 2020

AbstractPersonalized cognitive-behavioural therapy for obesity (CBT-OB) is a new treatment that combines the traditional procedures of standard behavioural therapy for obesity (i.e., self-monitoring, goal setting, stimulus control, contingency management, behavioural substitution, skills for increasing social support, problem solving and relapse prevention) with a battery of specific cognitive strategies and procedures. These enable the treatment to be individualized, and to help patients to address the cognitive processes that previous research has found to be associated with treatment discontinuation, the amount of weight lost and long-term weight-loss maintenance. The treatment programme can be delivered at three levels of care, outpatient, day hospital and residential, and includes six modules, which are introduced according to the individual patient’s needs as part of a flexible, personalized approach. The primary goals of CBT-OB are to help patients to (i) achieve, accept and maintain healthy weight loss; (ii) adopt a lifestyle conducive to weight control; and (iii) develop a stable “weight-control mindset”. A randomized controlled trial has found that 88 patients suffering from morbid obesity treated with CBT-OB followed a period of residential treatment achieved a mean weight loss of 15% after 12 months, with no tendency to regain weight between 6 and 12 months. The treatment efficacy is also supported by data from a study assessing the effects of group CBT-OB delivered in a real-world clinical setting. In that study, 77 patients with morbid obesity who completed the treatment achieved 9.9% weight loss after 18 months. These promising results, if confirmed by future clinical studies, suggest that CBT-OB has the potential to be more effective than traditional weight-loss lifestyle-modification programmes.
A novel transplantable model of lung cancer-associated tissue loss and disrupted muscle regeneration
Authors: Arneson-Wissink Paige C. , Ducharme Alexandra M. , Doles Jason D. 
Published: March 2020

Abstract
Background
Cancer-associated muscle wasting (CAW), a symptom of cancer cachexia, is associated with approximately 20% of lung cancer deaths and remains poorly characterized on a mechanistic level. Current animal models for lung cancer-associated cachexia are limited in that they (1) primarily employ flank transplantation methods, (2) have short survival times not reflective of the patient condition, and (3) are typically performed in young mice not representative of mean patient age. This study investigates a new model for lung cancer-associated cachexia that can address these issues and also implicates muscle regeneration as a contributor to CAW.

Methods
We used tail vein injection as a method to introduce tumor cells that seed primarily in the lungs of mice. Body composition of tumor-bearing mice was longitudinally tracked using NMR-based, echo magnetic resonance imaging (echoMRI). These data were combined with histological and molecular assessments of skeletal muscle to provide a complete analysis of muscle wasting.

Results
In this new lung CAW model, we observed (1) progressive loss in whole body weight, (2) progressive loss of lean and fat mass, (3) a circulating cytokine/inflammatory profile similar to that seen in other models of CAW, (4) histological changes associated with muscle wasting, and (5) molecular changes in muscle that implicate suppression of muscle repair/regeneration. Finally, we show that survival can be extended without lessening CAW by titrating injected cell number.

Conclusions
Overall, this study describes a new model of CAW that could be useful for further studies of lung cancer-associated wasting and accompanying changes in the regenerative capacity of muscle. Additionally, this model addresses many recent concerns with existing models such as immunocompetence, tumor location, and survival time.