bluuebunny/crossref_metadata_2025_split huggingface dataset:
2D kinematics of massive stars near the Galactic Centre
Authors: Libralato Mattia , Lennon Daniel J , Bellini Andrea , van der Marel Roeland , Clark Simon J , Najarro Francisco , Patrick Lee R , Anderson Jay , Bedin Luigi R , Crowther Paul A , de Mink Selma E , Evans Christopher J , Platais Imants , Sabbi Elena , Sohn Sangmo Tony 
Published: November 2020

ABSTRACT
The presence of massive stars (MSs) in the region close to the Galactic Centre (GC) poses several questions about their origin. The harsh environment of the GC favours specific formation scenarios, each of which should imprint characteristic kinematic features on the MSs. We present a 2D kinematic analysis of MSs in a GC region surrounding Sgr A* based on high-precision proper motions obtained with the Hubble Space Telescope. Thanks to a careful data reduction, well-measured bright stars in our proper-motion catalogues have errors better than 0.5 mas yr−1. We discuss the absolute motion of the MSs in the field and their motion relative to Sgr A*, the Arches, and the Quintuplet. For the majority of the MSs, we rule out any distance further than 3–4 kpc from Sgr A* using only kinematic arguments. If their membership to the GC is confirmed, most of the isolated MSs are likely not associated with either the Arches or Quintuplet clusters or Sgr A*. Only a few MSs have proper motions, suggesting that they are likely members of the Arches cluster, in agreement with previous spectroscopic results. Line-of-sight radial velocities and distances are required to shed further light on the origin of most of these massive objects. We also present an analysis of other fast-moving objects in the GC region, finding no clear excess of high-velocity escaping stars. We make our astro-photometric catalogues publicly available.
The role of mergers and interactions in driving the evolution of dwarf galaxies over cosmic time
Authors: Martin G , Jackson R A , Kaviraj S , Choi H , Devriendt J E G , Dubois Y , Kimm T , Kraljic K , Peirani S , Pichon C , Volonteri M , Yi S K 
Published: November 2020

ABSTRACT
Dwarf galaxies (M⋆ &lt; 109 M⊙) are key drivers of mass assembly in high-mass galaxies, but relatively little is understood about the assembly of dwarf galaxies themselves. Using the NewHorizon cosmological simulation (∼40 pc spatial resolution), we investigate how mergers and fly-bys drive the mass assembly and structural evolution of around 1000 field and group dwarfs up to z = 0.5. We find that, while dwarf galaxies often exhibit disturbed morphologies (5 and 20 per cent are disturbed at z = 1 and z = 3 respectively), only a small proportion of the morphological disturbances seen in dwarf galaxies are driven by mergers at any redshift (for 109 M⊙, mergers drive under 20 per cent morphological disturbances). They are instead primarily the result of interactions that do not end in a merger (e.g. fly-bys). Given the large fraction of apparently morphologically disturbed dwarf galaxies which are not, in fact, merging, this finding is particularly important to future studies identifying dwarf mergers and post-mergers morphologically at intermediate and high redshifts. Dwarfs typically undergo one major and one minor merger between z = 5 and z = 0.5, accounting for 10 per cent of their total stellar mass. Mergers can also drive moderate star formation enhancements at lower redshifts (3 or 4 times at z = 1), but this accounts for only a few per cent of stellar mass in the dwarf regime given their infrequency. Non-merger interactions drive significantly smaller star formation enhancements (around two times), but their preponderance relative to mergers means they account for around 10 per cent of stellar mass formed in the dwarf regime.
Using Smartphone-Based Accelerometer Data to Objectively Assess Outcomes in Spine Surgery
Authors: Basil Gregory W , Sprau Annelise C , Eliahu Karen , Borowsky Peter A , Wang Michael Y , Yoon Jang W 
Published: November 2020

Abstract

BACKGROUND
In order to deliver optimal patient care, spine surgeons must integrate technological changes to arrive at novel measures of functional outcomes. Historically, subjective patient-reported outcome (PRO) surveys have been used to determine the relative benefit of surgical treatments. Using smartphone-based accelerometers, surgeons now have the ability to arrive at objective outcome metrics.

OBJECTIVE
To use Apple Health (Apple Inc, Cupertino, California) data to approximate physical activity levels before and after spinal fusion as an objective outcome measurement.

METHODS
Personal activity data were acquired retrospectively from the cellphones of consenting patients. These data were used to measure changes in activity level (daily steps, flights climbed, and distance traveled) before and after patients underwent spine surgery at a single institution by a single surgeon. After data collection, we investigated the demographic information and daily physical activity pre- and postoperatively of participating patients.

RESULTS
Twenty-three patients were included in the study. On average, patients first exceeded their daily 1-yr average distance walked, flights climbed, and steps taken at 10.3 ± 14, 7.6 ± 21.1, and 8 ± 9.9 wk, respectively. Mean flights climbed, distance traveled, and steps taken decreased significantly from 6 mo prior to surgery to 2 wk postoperatively. Distance traveled and steps taken significantly increased from 6 mo prior to surgery to 7 to 12 mo postoperatively.

CONCLUSION
We demonstrated a valuable supplement to traditional PROs by using smartphone-based activity data. This methodology yields a rich data set that has the potential to augment our understanding of patient recovery.
Fresh street: the development and feasibility of a place-based, subsidy for fresh fruit and vegetables
Authors: Relton C , Crowder M , Blake M , Strong M 
Published: November 2020

Abstract

Background
Many UK communities experience food insecurity, and consume diets high in energy-dense, nutrient poor, processed foods and low in fruit and vegetables (FV). We explored a novel area-based approach to promote FV consumption and healthy eating in one such community.

Methods
We developed a weekly subsidy scheme for fresh FV with key local stakeholders in an area of socioeconomic deprivation in Northern England. The scheme (Fresh Street) offered five £1 vouchers to every household, regardless of income or household type. Vouchers were redeemable with local suppliers of fresh FV (not supermarkets). The feasibility of the scheme was assessed in four streets using rapid ethnographic assessment and voucher redemption information.

Results
Local councillors and public health teams were supportive of the scheme. Most eligible households joined the scheme (n = 80/97, 83%), and 89.3% (17 849/19 982) of vouchers issued were redeemed. Householders reported that the scheme made them think about what they were eating, and prompted them to buy and eat more FV.

Conclusions
This feasibility study reported high levels of acceptance for a place-based, household-level weekly FV subsidy scheme. Further research is required to evaluate the effectiveness of this approach to creating healthy diets, eating behaviours and food systems.
The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis
Authors: Davies Ruth , Williams Jessica , Sime Katie , Jin Hyun-Sun , Thompson Charlotte , Jordan Lauren , Lang Derek , Halcox Julian P , Ellins Elizabeth , Jones Gareth W , Jones Simon A , Rose-John Stefan , Williams Anwen , Choy Ernest 
Published: November 2020

Abstract

Objectives
Cardiovascular (CV) mortality in RA patients is 50% higher than in the general population. There is increasing recognition that systemic inflammation is a major driver of this. IL-6 is implicated in cardiovascular disease (CVD) in the general population but its role in CVD in RA is undefined. Of the two modes of IL-6 signalling, trans-signalling is pro-inflammatory whereas classical signalling is linked with inflammation resolution. This study examines the role of IL-6 trans-signalling in CVD in a mouse model and patients with RA.

Methods
Myography determined the effect of IL-6 trans-signalling blockade, using sgp130Fc, on aortic constriction in murine collagen-induced arthritis. Serum CCL2 and sVCAM-1 as soluble biomarkers of sIL-6R trans-signalling were investigated in a human cross-sectional study. An observational longitudinal study investigated the association between these biomarkers and progression of subclinical atherosclerosis in early RA by measuring carotid intima-media thickness (CIMT).

Results
sgp130Fc reduced arthritis severity, serum CCL2 and sVCAM-1 and restored vascular function in collagen-induced arthritis (CIA). In established RA, sVCAM-1 correlated with the 28-joint DAS (DAS28) and CV risk. In early RA, baseline DAS28 was associated with CIMT change at 6 months. CIMT ‘rapid progressors’ at 12 months had higher baseline sVCAM-1, haemoglobin A1c, cholesterol:high-density lipoprotein cholesterol ratio and LDL cholesterol.

Conclusions
IL-6 trans-signalling plays a pivotal role in vascular dysfunction in CIA. In early RA, sVCAM-1 was associated with progression of subclinical atherosclerosis. Inflammation from RA onset in CVD-susceptible individuals may accelerate atherosclerosis. IL-6 trans-signalling blockade may be beneficial to RA patients and perhaps for atherosclerosis in the general population.
Measuring disease activity in psoriatic arthritis: PASDAS implementation in a tightly monitored cohort reveals residual disease burden
Authors: Mulder Michelle L M , van Hal Tamara W , van den Hoogen Frank H J , de Jong Elke M  G  J   , Vriezekolk Johanna E , Wenink Mark H 
Published: November 2020

AbstractObjectivesWe aimed to investigate the disease activity and overall disease burden of (subgroups of) patients with PsA using the Psoriatic Arthritis Disease Activity Score (PASDAS) in an already tightly monitored cohort.MethodsThis is a cross-sectional study evaluating data from the first visit of 855 PsA patients after implementation of the PASDAS in our tightly monitored cohort [e.g. DAS 28 (DAS28) was provided as an anchor]. Differences in clinical outcomes between subgroups of patients using established cut-offs for disease activity status [i.e. very low (VLDA), low (LDA), moderate (MDA), and high disease activity (HDA)] were examined.ResultsBased on the PASDAS, 53.1% of patients were in VLDA/LDA. 29.5% of patients had ≥1 swollen joint, 20.6% had ≥1 enthesitis index point and 3.0% had active dactylitis. Based on DAS28, 77.5% of the patients were in VLDA/LDA. Patients reaching both DAS28 VLDA/LDA status and PASDAS VLDA/LDA status [N = 445 (52.0%)] were compared with patients reaching only DAS28 VLDA/LDA status [N = 218 (25.5%)]. For these latter patients, significantly worse scores on separate parameters were found in measures used for PASDAS/DAS28 calculation (e.g. swollen and tender joint count and patient’s visual analogue scale global disease activity) as well as other disease measures (e.g. function and inflammatory back pain). This result remained, even when the stricter VLDA cut-off was used for the DAS28.ConclusionPASDAS implementation uncovered relevant residual disease activity in a quarter of patients previously assessed as being in DAS28 VLDA/LDA, underscoring the potential value of PASDAS measurements in PsA clinical care.
Alternate Dosing Protocol for Magnesium Sulfate in Obese Women With Preeclampsia
Authors: Brookfield Kathleen F. , Tuel Kierstyn , Rincon Monica , Vinson Abbie , Caughey Aaron B. , Carvalho Brendan 
Published: November 2020

OBJECTIVE:
To evaluate whether obese women need greater doses of magnesium sulfate to obtain therapeutic serum concentrations for eclamptic seizure prevention.

METHODS:
Women with preeclampsia and a body mass index (BMI) of 35 or higher were randomly allocated to either the Zuspan regimen of magnesium sulfate (4-g intravenous [IV] loading dose, then a 1-g/h infusion) or to alternate dosing (6-g IV loading dose, then a 2-g/h infusion). Women had serum magnesium concentrations obtained at baseline, as well as after administration of magnesium sulfate at 1 hour, 4 hours, and delivery. The primary outcome was the proportion of women who had subtherapeutic serum magnesium concentrations (less than 4.8 mg/dL) 4 hours after administration. A sample size of 18 women per group was planned to compare the proportion of women with subtherapeutic serum magnesium concentrations in each group.

RESULTS:
From July 12, 2016, to March 14, 2019, 89 women with preeclampsia were screened and 37 were enrolled: 18 to the Zuspan regimen and 19 to the alternate regimen. A significantly greater proportion of women administered the Zuspan regimen had subtherapeutic serum magnesium concentrations at 4 hours (100% [95% CI 59–100] vs 63% [95% CI 41–81]; P=.01) compared with women administered the alternate higher dose regimen. At 4 hours, mean concentrations were significantly higher in the alternate regimen group (3.53 mg/dL±0.3 [Zuspan regimen] vs 4.41±0.5 [alternate regimen]; P<.01).

CONCLUSION:
The alternate dosing regimen of a 6-g IV loading dose followed by a 2-g/h IV maintenance dose more reliably achieves therapeutic serum magnesium concentrations (as defined by a concentration of at least 4.8 mg/dL) in obese women with preeclampsia.

CLINICAL TRIAL REGISTRATION:
ClinicalTrials.gov, NCT02835339.
Safety and Feasibility of Discharge Without an Opioid Prescription for Patients Undergoing Gynecologic Surgery
Authors: Margolis Benjamin , Andriani Leslie , Baumann Katherine , Hirsch Anna M. , Pothuri Bhavana 
Published: November 2020

OBJECTIVE:
To implement a quality-improvement intervention aimed at reducing unnecessary opioid prescriptions for patients who are undergoing gynecologic surgery.

METHODS:
This was a retrospective cohort study that included data from the pre– and post–quality-improvement initiative cohorts. Patients at an urban, tertiary academic medical center who were undergoing scheduled minimally invasive surgery and open abdominal surgery by a gynecologic oncologist were included. Patients underwent preoperative counseling, standardization of perioperative analgesia, and a postoperative opioid prescribing algorithm. Descriptive statistics were calculated for demographic and perioperative characteristics, process measures, and outcome measures.

RESULTS:
A total of 532 abdominal surgeries were analyzed. The total percentage of patients discharged with an opioid prescription decreased from 82.7% (n=229/276) to 23.1% (n=59/256) (P<.001) and was significantly reduced for all routes of surgery. The mean number of opioid tablets prescribed for all patients was significantly reduced from 7.2 tablets (SD=5.7) to 1.8 tablets (SD=4.3) (P<.001). Eighty-three percent of patients (n=97/117) who underwent minimally invasive hysterectomy and were discharged on postoperative day 0 or day 1 were not provided an opioid prescription. Fifty-one percent of patients who underwent laparotomy were discharged without an opioid prescription. The percentage of patients who required an opioid refill or new prescription in the preintervention and postintervention cohorts remained constant (6.5%, n=18/276 vs 5.9%, n=15/256, P=.75), as did postoperative calls for pain (8.3%, n=23/276 vs 10.9%, n=33/256).

CONCLUSION:
Patients who are undergoing scheduled abdominal gynecologic surgery can be safely discharged without opioid prescriptions with appropriate education and perioperative analgesia prescribing practices. These protocols and prescribing practices profoundly limit opioid prescriptions, which is an important factor in combating the ongoing opioid crisis.
Effect of Fasting on Total Bile Acid Levels in Pregnancy
Authors: Smith Devin D. , Kiefer Miranda K. , Lee Alan J. , Davis Sarah B. , Summerfield Taryn L. , Landon Mark B. , Rood Kara M. 
Published: November 2020

OBJECTIVE:
To evaluate differences between fasting and nonfasting bile acid levels in asymptomatic and symptomatic pregnant women.

METHODS:
This is a report of two prospective cohort studies describing bile acid levels in the fasting and nonfasting state in pregnancy. The first cohort included asymptomatic women with singleton pregnancies. Women with a diagnosis of cholestasis, symptoms of cholestasis, or intolerance to components of a standardized meal were excluded. Bile acid levels were measured during the second and third trimesters after fasting and again 2 hours after a standardized meal. The second cohort included symptomatic women with singleton pregnancies in whom fasting and nonfasting bile acid levels were measured at the time of symptom evaluation. A cutoff of 10 micromoles/L was used for diagnosis.

RESULTS:
A total of 27 women were included in the asymptomatic cohort. Median [interquartile range] fasting bile acid levels were significantly lower than nonfasting levels in both the second trimester (4.65 micromoles/L [1.02–29.57] vs 13.62 micromoles/L [2.03–40.26]; P<.001) and third trimester (8.31 micromoles/L [1.14–51.26] vs 17.35 micromoles/L [1.77–62.93]; P<.001). Bile acid levels exceeded 10 micromoles/L in 21% of the fasting samples and in 58% of the nonfasting samples in the third trimester. A total of 26 women were included in the symptomatic cohort. Median [interquartile range] fasting bile acid levels were significantly lower than nonfasting values (11.5 micromoles/L [7–56] vs 13.5 micromoles/L [9–142]; P<.001). Six patients in the symptomatic cohort (23%) had nonfasting bile acid levels greater than 10 micromoles/L that dropped below 10 micromoles/L when fasting.

CONCLUSION:
Fasting bile acid levels are significantly lower when compared with nonfasting values in both asymptomatic and symptomatic pregnant women. In asymptomatic women, nonfasting bile acid levels often exceeded 10 micromoles/L whereas fasting values did not. In symptomatic women, fasting bile acid levels resulted in 23% fewer diagnoses of cholestasis when compared with nonfasting values. These findings suggest that fasting evaluation of bile acid levels or a higher threshold for diagnosis of cholestasis should be considered.
Cesarean Delivery and Gender of Delivering Physicians
Authors: Hoxha Ilir , Sadiku Fitim , Lama Arber , Bunjaku Genta , Agahi Riaz , Statovci Jeta , Bajraktari Ilirjana 
Published: November 2020

OBJECTIVE:
To assess the association of the gender of the delivering physician and the odds of performing cesarean delivery.

DATA SOURCES:
CINAHL, ClinicalTrials.gov, Cochrane Library, PubMed, Scopus and Web of Science from the first year of records through May 2020.

METHODS OF STUDY SELECTION:
We included studies that reported odds ratios (OR), or data allowing the calculation of ORs, for cesarean delivery performed by female and male delivering physicians. We also included studies that reported the preference of physicians for performing cesarean deliveries.

TABULATION, INTEGRATION, AND RESULTS:
Independent data extraction was carried out by at least two researchers. Standard inverse-variance random effects meta-analysis was used to generate overall ORs. Finally, in two separate meta-analyses, we analyzed 15 studies containing clinical data for 1,269,625 births, and 11 studies containing data for the preference for delivery mode of 4,911 obstetricians. Both the crude and adjusted odds of a cesarean delivery were lower for those performed by female physicians (crude OR 0.75, 95% CI 0.68–0.84, τ2=0.029, adjusted OR 0.74, 95% CI 0.65–0.85, τ2=0.031). We also found that female physicians had a lower preference for cesarean delivery in both crude and adjusted analysis (crude OR 0.59, 95% CI 0.36–0.96, I2=77%, adjusted OR 0.58, 95% CI 0.40–0.84, I2=67%).

CONCLUSION:
Female physicians are less likely to perform cesarean delivery and less likely to prefer it. This was observed across different health systems and populations.

SYSTEMATIC REVIEW REGISTRATION:
PROSPERO, CRD42020158442.
Results of thin-cap small-incision lenticule extraction
Authors: Taneri Suphi , Arba-Mosquera Samuel , Rost Anika , Hansson Caroline , Dick H. Burkhard 
Published: November 2020

Purpose:
To evaluate the influence of a thin cap in small-incision lenticule extraction (SMILE) for the correction of myopia or myopic astigmatism.

Setting:
Tertiary care private practice.

Methods:
A chart review of 102 eyes of 51 patients was performed. The effect of 120 µm vs 100 μm cap thickness on postoperative spherical equivalent refraction (SEQ), cylinder, corrected and uncorrected visual acuities, and ease of lenticule separation was assessed in a contralateral manner, whereas all other parameters were identical between eyes (including optical zone, minimum lenticule thickness, incision size, and energy and spot settings) using paired t test.

Results:
At 3 months postoperatively, SMILE with 120 μm cap thickness was undercorrected in SEQ relative to SMILE with 100 μm cap thickness in a cohort of 102 eyes of 51 consecutive patients. The difference of 0.06 ± 0.39 diopter (or 0.7% ± 5.7%) did not reach statistical significance. Postoperative cylinder was not statistically different in both groups. Visual acuity was similar in both groups. Ease of lenticule separation was identical in both groups. Suction time was shorter with a 100 μm cap (P < .005). Postoperative central residual stromal thickness was 20 ± 15 μm thicker with a 100 μm cap (P < .0001). Adverse events were comparable.

Conclusions
Postoperative refraction, visual acuity, ease of lenticule separation, and incidence of adverse events were not significantly affected by cap thickness. Surgeons might safely use 100 μm instead of 120 μm caps without nomogram adjustment. Alternatively, after suction loss during the lenticule cut, a second docking with a programmed cap thickness of 100 μm (and a larger optical zone) might be a rescue technique enabling surgeons to still perform the intended SMILE procedure.
Cataract surgery after myopic laser in situ keratomileusis: objective analysis to determine best formula and keratometry to use
Authors: Sandoval Helga P. , Serels Chad , Potvin Richard , Solomon Kerry D. 
Published: November 2020

Purpose:
To objectively determine which formula/keratometry combination was best for calculating intraocular lens (IOL) sphere power in eyes with a history of myopic laser in situ keratomileusis (LASIK).

Setting:
One practice in the United States.

Design:
Retrospective, unmasked, nonrandomized chart review.

Methods:
Consecutive patients undergoing cataract surgery after previous myopic LASIK were included. Eyes had to have a postoperative refraction at least 3 weeks postoperatively. IOL power was calculated with the ASCRS online postrefractive IOL calculator using anterior keratometry and recalculated using total corneal power (TK). The accuracy of treatment was calculated and compared between different formulas and keratometry methods including intraoperative aberrometry (IA).

Results:
Data from 101 eyes, 44 of which had TK available, were analyzed. Using TK, the Wang-Koch-Maloney formula had the highest percentages of eyes with expected spherical equivalent refractive errors within 0.50 diopter (D) and 1.00 D of plano (57% and 87%, respectively). With anterior keratometry, the Barrett True-K formula had the highest percentages (64% and 92%, respectively) but was not significantly better than the Wang-Koch-Maloney formula, with expected errors within ±0.50 and ±1.00 D (P > .2, McNemar test). Expected sphere results based on IA were not significantly different than for Barrett True-K within ±0.50 D or within ±1.00 D (P > .2, McNemar test).

Conclusions:
Using TK in existing post-LASIK formulas did not seem beneficial. The formulas might have to be optimized for use with TK. The best expected results were obtained with the Barrett True-K and Haigis-L formulas using anterior keratometry. IA did not seem to materially improve results.