bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coupling of CSF and sagittal sinus pressure in adult patients with pseudotumour cerebri
Authors: Lalou Afroditi-Despina , Czosnyka Marek , Czosnyka Zofia H. , Krishnakumar Deepa , Pickard John D. , Higgins Nick J. 
Published: December 2019

Abstract
Objective
Pseudotumour cerebri syndrome (PTCS including idiopathic intracranial hypertension) is characterised by the symptoms and signs of raised cerebrospinal fluid pressure (CSFp) in the absence of ventricular dilatation or an intracranial mass lesion. Its aetiology is unknown in the majority of cases but there is much evidence for impaired CSF absorption. Traditionally, sagittal sinus pressure has been considered to be independent of CSF pressure in adults. However, the discovery of stenoses of intracranial venous sinuses and introduction of venous sinus stenting has highlighted the importance of the venous drainage in PTCS. In this study, we have explored the relationship between CSFp and SSp before and during a CSF infusion test and during CSF drainage.

Materials and methods
Ten patients (9 females:1 male) with PTCS underwent infusion studies in parallel with direct retrograde cerebral venography. Both SSp and CSFp were recorded at a baseline and during CSFp elevation in a course of a CSF infusion test. The drainage of CSF after the CSF infusion was performed in 7 patients. In 5 cases, jugular venous pressure was also measured.

Results
CSFp and SSp including their amplitudes correlated significantly and strongly both at baseline (R = 0.96; p = 0.001) and during infusion (R = 0.92; p = 0.0026). During drainage, this correlation was maintained until SSp reached a stable value, whereas CSFp continued to decrease.

Conclusions
In this series of ten patients with PTCS, CSFp and SSp were coupled, both at baseline and during infusion. The implications of such coupling for the calculation of CSF outflow resistance are discussed.
A phase 3 study of nivolumab in previously treated advanced gastric or gastroesophageal junction cancer (ATTRACTION-2): 2-year update data
Authors: Chen Li-Tzong , Satoh Taroh , Ryu Min-Hee , Chao Yee , Kato Ken , Chung Hyun Cheol , Chen Jen-Shi , Muro Kei , Kang Won Ki , Yeh Kun-Huei , Yoshikawa Takaki , Oh Sang Cheul , Bai Li-Yuan , Tamura Takao , Lee Keun-Wook , Hamamoto Yasuo , Kim Jong Gwang , Chin Keisho , Oh Do-Youn , Minashi Keiko , Cho Jae Yong , Tsuda Masahiro , Sameshima Hiroki , Kang Yoon-Koo , Boku Narikazu 
Published: December 2019

Abstract
Background
Nivolumab showed improvement in overall survival (OS) in ATTRACTION-2, the first phase 3 study in patients with gastric/gastroesophageal junction (G/GEJ) cancer treated with ≥ 2 chemotherapy regimens. The 2-year follow-up results of ATTRACTION-2 are presented herein.

Methods
ATTRACTION-2 was a randomized, double-blind, placebo-controlled, phase 3 trial (49 sites; Japan, South Korea, and Taiwan). The median (min–max) follow-up period was 27.3 (24.1–36.3) months. The primary endpoint was OS. A subanalysis of OS was performed based on best overall response and tumor-programmed death ligand-1 (PD-L1) expression status.

Results
Overall, 493 of 601 screened patients were randomized (2:1) to receive nivolumab (330) or placebo (163). OS (median [95% confidence interval; CI]) was significantly longer in the nivolumab group (5.26 [4.60–6.37] vs 4.14 [3.42–4.86] months in placebo group) at the 2-year follow-up (hazard ratio [95% CI], 0.62 [0.51–0.76]; P < 0.0001). A higher OS rate was observed in the nivolumab vs placebo group at 1 (27.3% vs 11.6%) and 2 years (10.6% vs 3.2%). The OS benefit was observed regardless of tumor PD-L1 expression. Among patients with a complete or partial response (CR or PR) in the nivolumab group, the median OS (95% CI) was 26.6 (21.65—not applicable) months; the OS rates at 1 and 2 years were 87.1% and 61.3%, respectively. No new safety signals were identified.

Conclusions
Nivolumab treatment resulted in clinically meaningful long-term improvements in OS in patients with previously treated G/GEJ cancer. The long-term survival benefit of nivolumab was most evident in patients with a CR or PR.
Recent developments in cognitive fMRI for temporal lobe epilepsy
Authors: Schmidbauer Victor , Bonelli Silvia 
Published: December 2019

AbstractEpilepsy is frequently accompanied by severe cognitive side effects. Temporal lobe epilepsy (TLE), and even successful surgical treatment, may affect cognitive function, in particular language as well as verbal and visual memory function. Epilepsy arising from the temporal lobe can be controlled surgically in up to 70% of patients. The goals of epilepsy surgery are to remove the brain areas generating the seizures without causing or aggravating neuropsychological deficits. This requires accurate localization of the brain areas generating the seizures (“epileptogenic zone”) and the areas responsible for motor and cognitive functions, such as language and memory (“essential brain regions”) during presurgical evaluation. In the past decades, functional magnetic resonance imaging (fMRI) has been increasingly used to noninvasively lateralize and localize not only primary motor and somatosensory areas, but also brain areas that are involved in everyday language and memory processes. The imaging modality also shows potential for predicting the effects of temporal lobe resection on language and memory function. Together with other MRI modalities, cognitive fMRI is a promising tool to improve surgical strategies tailored to individual patients with regard to functional outcome, by virtue of definition of epileptic cerebral areas that need to be resected and eloquent areas that need to be spared.The aim of this review is to provide an overview of recent developments and practical recommendations for the clinical use of cognitive fMRI in TLE.
Supporting Students in Using Energy Ideas to Interpret Phenomena: The Role of an Energy Representation
Authors: Kubsch Marcus , Nordine Jeffrey , Fortus David , Krajcik Joseph , Neumann Knut 
Published: December 2019

AbstractIn the sciences, energy is an important idea to get insight into phenomena, as energy can help to reveal hidden systems and processes. However, students commonly struggle to use energy ideas to interpret and explain phenomena. To support students in using energy ideas to interpret and explain phenomena, a range of different graphical representations are commonly used. However, there is little empirical research regarding whether and how these representations actually support students’ ability to use energy ideas. Building on common ways of representing energy transfer, we address this issue by exploring whether, and if so how, a specific representation called the energy transfer model (ETM) supports middle school students’ interpretation of phenomena using the idea of energy transfer. We conducted an interview study with N = 30 8th grade students in a quasi-experimental setting and used qualitative content analysis to investigate student answers. We found evidence that students who construct an ETM when making sense of phenomena consider the role of energy transfers between systems more comprehensively, i.e., they reason about hidden processes and systems to a larger extent than students who do not construct an ETM.
Whither the University? Universities of Technology and the Problem of Institutional Purpose
Authors: Miller Seumas 
Published: December 2019

AbstractThere is a need to provide an appropriate normative conception of the modern university: a conception which identifies its unifying purposes and values and, thereby, gives direction to institutional role occupants, governments, public policymakers and other would-be institutional designers. Such a conception could admit differences between modern universities; differences, for example, between so-called universities of technology and other universities. Indeed, it is preferable to frame the issue at the level of higher education or university systems rather than at the level of individual universities. According to the teleological normative theory of social institutions, social institutions are organizations or systems of organizations that provide collective goods by means of joint activity; universities are no exception. So what are the fundamental collective good(s) that universities of technology, or the larger systems of which they are a part, ought to be providing and how are they travelling in this regard? This is the question addressed in this paper.
A synopsis of Stenostephanus Nees (Acanthaceae) in Bolivia
Authors: Wood John R. I. 
Published: December 2019

Summary12 species of Stenostephanus Nees occur in Bolivia, two of which, S. madidiensis J.R.I.Wood and S. sehuencasii J.R.I.Wood are described as new. Ten species are endemic to the country with all growing on the humid eastern slopes of the Andes. The distribution of all Bolivian species is described and mapped and implications for conservation are discussed. A key to the species found in Bolivia and a table of their principal distinguishing characteristics are provided. The new species are illustrated with line drawings and photographs.
Genetic characterization of cassava (Manihot esculenta Crantz) genotypes using agro-morphological and single nucleotide polymorphism markers
Authors: Karim Kumba Y. , Ifie Beatrice , Dzidzienyo Daniel , Danquah Eric Y. , Blay Essie T. , Whyte Jim B. A. , Kulakow Peter , Rabbi Ismail , Parkes Elizabeth , Omoigui Lucky , Norman Prince E. , Iluebbey Peter 
Published: December 2019

AbstractDearth of information on extent of genetic variability in cassava limits the genetic improvement of cassava genotypes in Sierra Leone. The aim of this study was to assess the genetic diversity and relationships within 102 cassava genotypes using agro-morphological and single nucleotide polymorphism markers. Morphological classification based on qualitative traits categorized the germplasm into five different groups, whereas the quantitative trait set had four groups. The SNP markers classified the germplasm into three main cluster groups. A total of seven principal components (PCs) in the qualitative and four PCs in the quantitative trait sets accounted for 79.03% and 72.30% of the total genetic variation, respectively. Significant and positive correlations were observed between average yield per plant and harvest index (r = 0.76***), number of storage roots per plant and harvest index (r = 0.33*), height at first branching and harvest index (0.26*), number of storage roots per plant and average yield per plant (r = 0.58*), height at first branching and average yield per plant (r = 0.24*), length of leaf lobe and petiole length (r = 0.38*), number of leaf lobe and petiole length (r = 0.31*), width of leaf lobe and length of leaf lobe (r = 0.36*), number of leaf lobe and length of leaf lobe (r = 0.43*), starch content and dry matter content (r = 0.99***), number of leaf lobe and root dry matter (r = 0.30*), number of leaf lobe and starch content (r = 0.28*), and height at first branching and plant height (r = 0.45**). Findings are useful for conservation, management, short term recommendation for release and genetic improvement of the crop.
Can We Agree on What Robots Should be Allowed to Do? An Exercise in Rule Selection for Ethical Care Robots
Authors: Vanderelst Dieter , Willems Jurgen 
Published: December 2019

AbstractFuture Care Robots (CRs) should be able to balance a patient’s, often conflicting, rights without ongoing supervision. Many of the trade-offs faced by such a robot will require a degree of moral judgment. Some progress has been made on methods to guarantee robots comply with a predefined set of ethical rules. In contrast, methods for selecting these rules are lacking. Approaches departing from existing philosophical frameworks, often do not result in implementable robotic control rules. Machine learning approaches are sensitive to biases in the training data and suffer from opacity. Here, we propose an alternative, empirical, survey-based approach to rule selection. We suggest this approach has several advantages, including transparency and legitimacy. The major challenge for this approach, however, is that a workable solution, or social compromise, has to be found: it must be possible to obtain a consistent and agreed-upon set of rules to govern robotic behavior. In this article, we present an exercise in rule selection for a hypothetical CR to assess the feasibility of our approach. We assume the role of robot developers using a survey to evaluate which robot behavior potential users deem appropriate in a practically relevant setting, i.e., patient non-compliance. We evaluate whether it is possible to find such behaviors through a consensus. Assessing a set of potential robot behaviors, we surveyed the acceptability of robot actions that potentially violate a patient’s autonomy or privacy. Our data support the empirical approach as a promising and cost-effective way to query ethical intuitions, allowing us to select behavior for the hypothetical CR.
Impact of disability on the transitions to adulthood of men and women in Cameroon
Authors: Mouté Charles , Loû Annabel Desgrées du , Beninguisse Gervais , DeBeaudrap Pierre 
Published: December 2019

The transition to adulthood is a critical stage in human development because it shapes the future lives of many young people. Little is known about how disability affects this transition. Most of the available evidence comes from high-resource settings, where the situation differs greatly from that of resource-limited countries. Using the data from the HandiVIH ANRS 12302 study, we aimed to examine the effect of disability on the social markers of the transition to adulthood in an African context with regard to gender and the nature and severity of the limitations. Our results show that men and women with disabilities experience significant delays in completing the different transitions to adulthood and, consequently, live in more precarious situations at the beginning of adulthood. We also found complex variations in the effects of disability with regard to disability characteristics and gender. These results call for gender- and disability-sensitive transitional programmes to achieve the goal of equal opportunity as envisioned in the sustainable development goals.
Measuring outcomes and monitoring progress in the era of evidence-based clinical practice
Authors: Tate Robyn L. 
Published: December 2019

AbstractHealth outcome measurement is a growth industry. Thousands of behavioural assessment instruments, developed for neurological populations alone, are available for diagnosis, prediction and evaluation of interventions. The task of selecting the best instrument for the purpose at hand is thus a daunting one for the clinician and researcher. Fortunately, there are guides that make the task easier. This presidential address covers three interrelated themes that inform assessment in neurorehabilitation: First, it reviews current concepts and the status of behavioural assessment in neurorehabilitation. It then examines evidence-based clinical practice as applied to assessment of function, along with methods to benchmark the scientific quality of assessment instruments. Finally, the article considers the need to move beyond outcome measurement in the neurorehabilitation setting.
Terror, Hate and the Demands of Counter-Speech
Authors: Howard Jeffrey W. 
Published: December 2019

AbstractIt is a familiar mantra of American politics that the best response to dangerous speech that incites violence and spreads hate is ‘more speech’. Yet the principle obscures at least three crucial questions. Who, in particular, is to undertake the counter-speech that the doctrine recommends? What, exactly, are they required to do? And why is it morally justified to demand that they do it? This article argues that if citizens are to rely on counter-speech to defuse the dangers of dangerous expression, it is not enough to cheerlead its abstract importance and then sit back and hope for the best. Someone needs to do the work, and do it well. The article defends the thesis that all citizens have a moral duty to engage in counter-speech against dangerous expression. Focusing on counter-speech against expression that implicitly or explicitly advocates wrongful criminal violence, it argues that these duties can be derived from a much more basic normative source: the samaritan obligation, held by all moral agents, to rescue others from risks of harm. The specification of these duties' content, however, depends upon interdisciplinary work that integrates normative theory with social scientific research on human communication.
Analyzing designed experiments: Should we report standard deviations or standard errors of the mean or standard errors of the difference or what?
Authors: Kozak Marcin , Piepho Hans-Peter 
Published: December 2019

AbstractANOVA, one of the most common statistical methods applied in agronomy, offers a variety of results we can report when analyzing designed experiments. The focus, of course, is on treatment means, but what should we report to characterize precision? Should we choose treatment standard deviations (SDs) or standard errors of the mean or standard errors of the difference (SEDs)? We discuss why treatment raw SDs should not be reported as the result of ANOVA, and point out that most of the time it is SEDs that should be provided.
Mating behaviour of the leucosiid crabPyrhila pisum(De Haan, 1841)
Authors: Kobayashi Satoshi , Vazquez Archdale Miguel 
Published: December 2019

AbstractMating behaviour of the leucosiid crabPyrhila pisumwas studied in the laboratory and tidal flats in Japan. Most males actively approached females. Males started guarding females without any courtship behaviour (pre-copulatory guarding). Males began copulation within several minutes. The copulation continued for about 1–2 h, following which males began post-copulatory guarding. This guarding lasted from almost 0 to over 3 days, but its duration was generally much longer than that prior to copulation. Release of guarding was not linked to ovulation by females. Long-term rearing experiments revealed that both sexes ofP. pisumcould copulate multiple times with various mates. Developmental stages of the embryos recorded from copulating ovigerous females widely varied; their timing of copulation may not be fixed. In the tidal flat, wandering males frequently contacted with other individuals, but without distinguishing single males, single females and pairs ofP. pisum, orHemigrapsus takanoi. MaleP. pisumcannot recognize female conspecifics, and they approach their mates relying only on vision, without using any attractive cues from females. In cases in which males encountered pairing crabs, they successfully stole the females when the guardians were smaller than the challengers, suggesting that effectiveness of guarding depends on male size. Among the mating pairs, males tended to be larger than females, and the tendency of size-assortative mating was weak or absent. Therefore, the mating behaviour ofP. pisumis not elaborate, although their guarding behaviour may contribute to improve success to some degree.
Mary Wollstonecraft's Political Political Theory
Authors: Frazer Elizabeth 
Published: December 2019

AbstractThis paper separates Wollstonecraft's critical concept of “machiavelian” power and the capacity for domination, from a neutral concept of politics as the complex processes surrounding the power to govern, from her normative account of popular sovereignty which emphasizes collective political power to ensure the discharge of natural duty by way of civil and political rights and duties. Wollstonecraft's voice as political judge—which is audible throughout her work, but particularly clearly in her book on the French Revolution—articulates the ways that political power can be abused and misused, and can also be effective. Her theory is political in several ways: she interrogates the nature of political power and its explanatory importance; she consistently articulates political judgment about matters both conventionally political and social; she offers a theoretical justification for the expansion of the scope of politics to cover relations that hitherto were thought to be outside its domain; and finally her work itself constitutes a political intervention.
Identification and frequency of consumption of wild edible plants over a year in central Tunisia: a mixed-methods approach
Authors: Dop Marie Claude , Kefi Fayçal , Karous Olfa , Verger Eric O , Bahrini Asma , Ghrabi Zeineb , El Ati Jalila , Kennedy Gina , Termote Céline ,   the MEDINA Study Group
Published: December 2019

AbstractObjective:To identify wild plants used as food and assess their frequency of consumption over a year in a region of Tunisia where agriculture is undergoing a major transformation from smallholder farming to an intensive high-input agricultural system.Design:Qualitative ethnobotanical study followed by a survey of women’s frequency of consumption of wild plants conducted using FFQ at quarterly intervals.Setting:Sidi Bouzid governorate of central Tunisia.Participants:Mixed-gender group of key informants (n 14) and focus group participants (n 43). Survey sample of women aged 20–49 years, representative at governorate level (n 584).Results:Ethnobotanical study: thirty folk species of wild edible plants corresponding to thirty-five taxa were identified by key informants, while twenty folk species (twenty-five taxa) were described by focus groups as commonly eaten. Population-based survey: 98 % of women had consumed a wild plant over the year, with a median frequency of 2 d/month. Wild and semi-domesticated fennel (Foeniculum vulgare Mill. and Anethum graveolens) was the most frequently consumed folk species. Women in the upper tertile of wild plant consumption frequency were more likely to be in their 30s, to live in an urban area, to have non-monetary access to foods from their extended family and to belong to wealthier households.Conclusions:In this population, wild edible plants, predominantly leafy vegetables, are appreciated but consumed infrequently. Their favourable perception, however, offers an opportunity for promoting their consumption which could play a role in providing healthy diets and mitigating the obesity epidemic that is affecting the Tunisian population.
The religious origins of the rule of law
Authors: Hill Peter J. 
Published: December 2019

AbstractThe background conditions for the emergence of the rule of law are important but underdeveloped. This paper discusses current theories of the origin of the rule of law, arguing that they are useful but incomplete. In addition to those theories, the Jewish and Christian concept of all human beings as God's image bearers is an important contributor to the rule of law in Western civilization. The formulation of universal human equality is not, however, a sufficient condition for the emergence of the rule of law. The concept has taken centuries of articulation in different institutions and social settings. It only reached full fruition when it was joined with an understanding of appropriate legal and political systems as expressed by political theorists such as Locke, Montesquieu, and Madison.