bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical profile and outcome of classical Hodgkin lymphoma treated with a risk‐adapted approach in a tertiary cancer center in India
Authors: Parambil Badira Cheriyalinkal , Narula Gaurav , Prasad Maya , Shah Sneha , Shet Tanuja , Shridhar Epari , Khanna Nehal , Laskar Siddhartha , Gujral Sumeet , Sankaran Hari , Banavali Shripad 
Published: November 2019

AbstractBackgroundClassical Hodgkin lymphoma (cHL) has excellent survival rates, but late effects are an issue and dictate modern approaches. We analyzed the clinical profile and outcome of cHL treated on a risk‐adapted approach aimed at reducing late effects while improving historical outcomes at our center.ProcedureChildren (≤15 years) consecutively treated for cHL from January 2013 through December 2016 were retrospectively analyzed. 18FDG‐PET‐CT–based staging and response assessment was done after two cycles for early response (ERA) and end of chemotherapy (late‐response assessment [LRA]) if not in complete response (CR; Deauville < 4) at ERA. Stages IA/IB/IIA were low risk (LR) and received two cycles of ABVD (adriamycin/bleomycin/vinblastine/dacarbazine). Stages IAX/IBX/IIAX/IIB/IIIA were intermediate risk (IR), and stages IIBE/IIBX/IIIAE/IIIAX/IIIB/IVA/IVB were high risk (HR). Both received two cycles of OEPA (oncocristine/etoposide/prednisolone/adriamycin). Those in ERA‐CR received two cycles of ABVD if LR, and two and four cycles of COPDac (cyclophosphamide/oncocristine/prednisolone/dacarbazine), respectively, for IR and HR. Involved‐field radiotherapy (IFRT) was given to bulky sites and ERA < CR. Those at LRA < CR (Deauville < 3) or progression at any stage received salvage regimens.ResultsIn the study period, 126 patients were identified who received the above protocol. There were 12 LR, and 114 advanced staged Hodgkin lymphoma (AHL) (18, IR; 96, HR) of which 91 (79.8%) had bulky sites. Eight (66.6%) LR and 93 (83%) AHL patients achieved ERA‐CRs. IFRT was given to 4 (33.3%) LR patients with ERA < CR, and 92 (80.7%) of AHL (91 bulky sites; 1 ERA < CR). At a median follow‐up of 31 months (range, 17–62), three‐year event‐free survival (EFS) and overall survival (OS) were both 100% for LR, and 94.4% (95% CI, 66.0%–99.2%) for IR, whereas for HR it was 90.3% (95% CI, 82.2%–94.8%) and 92.6% (95% CI, 85.2%–96.4%), respectively.ConclusionsChildren with HL have favorable outcomes with manageable toxicities when treated on a risk‐stratified and adapted approach. A high proportion of AHL have bulky disease necessitating IFRT, a concern that will have to be factored in future strategies.
Sarcopenia: Tilting the Balance of Protein Homeostasis
Authors: Tan Kuan Ting , Ang Seok‐Ting Jamie , Tsai Shih‐Yin 
Published: November 2019

AbstractSarcopenia, defined as age‐associated decline of muscle mass and function, is a risk factor for mortality and disability, and comorbid with several chronic diseases such as type II diabetes and cardiovascular diseases. Clinical trials showed that nutritional supplements had positive effects on muscle mass, but not on muscle function and strength, demonstrating our limited understanding of the molecular events involved in the ageing muscle. Protein homeostasis, the equilibrium between protein synthesis and degradation, is proposed as the major mechanism underlying the development of sarcopenia. As the key central regulator of protein homeostasis, the mammalian target of rapamycin (mTOR) is proposed to be essential for muscle hypertrophy. Paradoxically, sustained activation of mTOR complex 1 (mTORC1) is associated with a loss of sensitivity to extracellular signaling in the elderly. It is not understood why sustained mTORC1 activity, which should induce muscle hypertrophy, instead results in muscle atrophy. Here, recent findings on the implications of disrupting protein homeostasis on muscle physiology and sarcopenia development in the context of mTOR/protein kinase B (AKT) signaling are reviewed. Understanding the role of these molecular mechanisms during the ageing process will contribute towards the development of targeted therapies that will improve protein metabolism and reduce sarcopenia.
Analysis and summarizing of discourse in Moroccan sociolect language
Authors: Mansouri Fadoua , Abdelalim Sadiq 
Published: November 2019

AbstractMoroccan internauts tend these days to use a very new specific language, a new trend of communication on the web, mainly on social media, to express their opinions and exchange their ideas, and that what we greed to call the Moroccan sociolect language given it extensive use by almost all Moroccan netizens.Since our final purpose is to be able to analyze the opinions of these internauts community, it is mandatory to first understand the language they are using to communicate on the web, thus, in this paper, we present in details the specific features of this Moroccan sociolect language, also we propose a set of steps, models and algorithms to follow in order to understand and summarize a Moroccan sociolect text.
Hairy black hole chemistry
Authors: Astefanesei Dumitru , Mann Robert B. , Rojas Raúl 
Published: November 2019

Abstract
We study the thermodynamics of an exact hairy black hole solution in Anti- deSitter (AdS) spacetime. We use the counterterm method supplemented with boundary terms for the scalar field to obtain the thermodynamic quantities and stress tensor of the dual field theory. We then extend our analysis by considering a dynamical cosmological constant and verify the isoperimetric inequality. Unlike the thermodynamics of Reissner- Nordström (RN) black hole in this ‘extended’ framework, the presence of the scalar field and its self-interaction makes also the criticality possible in the grand canonical ensemble. In the canonical ensemble, we prove that, in fact, there exist two critical points. Finally we comment on a different possible interpretation that is more natural in the context of string theory.
Rank-initial embeddings of non-standard models of set theory
Authors: Kindvall Gorbow Paul 
Published: November 2019

AbstractA theoretical development is carried to establish fundamental results about rank-initial embeddings and automorphisms of countable non-standard models of set theory, with a keen eye for their sets of fixed points. These results are then combined into a “geometric technique” used to prove several results about countable non-standard models of set theory. In particular, back-and-forth constructions are carried out to establish various generalizations and refinements of Friedman’s theorem on the existence of rank-initial embeddings between countable non-standard models of the fragment $${\mathrm {KP}}^{{\mathcal {P}}}$$

KP

P

+ $$\Sigma _1^{{\mathcal {P}}}$$

Σ
1
P

-Separation of $${\mathrm {ZF}}$$
ZF
; and Gaifman’s technique of iterated ultrapowers is employed to show that any countable model of $${\mathrm {GBC}} + \text {``}{\mathrm {Ord}}\text { is weakly compact''}$$

GBC
+
``
Ord

is weakly compact''

can be elementarily rank-end-extended to models with well-behaved automorphisms whose sets of fixed points equal the original model. These theoretical developments are then utilized to prove various results relating self-embeddings, automorphisms, their sets of fixed points, strong rank-cuts, and set theories of different strengths. Two examples: The notion of “strong rank-cut” is characterized (i) in terms of the theory $${\mathrm {GBC}} + \text {``}{\mathrm {Ord}}\text { is weakly compact''}$$

GBC
+
``
Ord

is weakly compact''

, and (ii) in terms of fixed-point sets of self-embeddings.
Evaluation of eazyplex® SuperBug CRE Test for Beta-Lactamase Genes Detection in Klebsiella spp. and P. aeruginosa Strains
Authors: Sękowska Alicja , Bogiel Tomasz , Gospodarek-Komkowska Eugenia 
Published: November 2019

AbstractThe multi-drug resistance of Gram-negative rods is one of the most important issues of present medicine. In recent years, more and more strains resistant to the majority or to all possible therapeutic options have been isolated—especially Klebsiella spp. and Pseudomonas spp. representatives. It is very important to detect strains with these phenotypes as quickly and reliably as possible. The aim of the study was to evaluate the usefulness of eazyplex® SuperBug CRE test (Amplex Diagnostics) for the detection of the most important beta-lactam resistance genes. eazyplex® SuperBug CRE test is based on the loop-mediated isothermal amplification (LAMP) method, and detects genes for the following beta-lactamases: KPC, NDM-1, VIM, OXA-48, CTX-M1, CTX-M9 and OXA-181. The study involved 87 strains. For all of the positive strains in the LAMP method, additional PCR were performed to increase the spectrum of ESBLs detected by the genes encoding for enzymes belonging to TEM and SHV families. The results obtained by the tested method and standard PCR were consistent for all Klebsiella spp. strains. The discrepancy between the evaluated test and PCR results was observed for one P. aeruginosa strain. The eazyplex® SuperBug CRE test can be used for quick detection of the most important beta-lactam resistance mechanisms amongst Gram-negative rods.
Mutation-driven epigenetic alterations as a defining hallmark of central cartilaginous tumours, giant cell tumour of bone and chondroblastoma
Authors: Venneker Sanne , Szuhai Karoly , Hogendoorn Pancras C. W. , Bovée Judith V. M. G. 
Published: November 2019

AbstractRecently, specific driver mutations were identified in chondroblastoma, giant cell tumour of bone and central cartilaginous tumours (specifically enchondroma and central chondrosarcoma), sharing the ability to induce genome-wide epigenetic alterations. In chondroblastoma and giant cell tumour of bone, the neoplastic mononuclear stromal-like cells frequently harbour specific point mutations in the genes encoding for histone H3.3 (H3F3A and H3F3B). The identification of these driver mutations has led to development of novel diagnostic tools to distinguish between chondroblastoma, giant cell tumour of bone and other giant cell containing tumours. From a biological perspective, these mutations induce several global and local alterations of the histone modification marks. Similar observations are made for central cartilaginous tumours, which frequently harbour specific point mutations in the metabolic enzymes IDH1 or IDH2. Besides an altered methylation pattern on histones, IDH mutations also induce a global DNA hypermethylation phenotype. In all of these tumour types, the mutation-driven epigenetic alterations lead to a highly altered transcriptome, resulting for instance in alterations in differentiation. These genomic alterations have diagnostic impact. Further research is needed to identify the genes and signalling pathways that are affected by the epigenetic alterations, which will hopefully lead to a better understanding of the biological mechanism underlying tumourigenesis.
Peripheral Vascular Disease in Women: Therapeutic Options in 2019
Authors: Saati Ammar , AlHajri Noora , Ya’qoub Lina , Ahmed Waqar , Alasnag Mirvat 
Published: November 2019

AbstractPurpose of reviewIn recent years, there have been advances in the prevention, management, and control of peripheral vascular disease (PVD). There is a trend towards aggressive risk factor modification, noninvasive screening, and endovascular revascularization with surgical approaches reserved only for select cases. This article reviews the different management strategies ranging from pharmacotherapy, revascularization, and rehabilitation with an emphasis on the response of women to these therapies.Recent findingsOverall, the representation of women in the majority of the published data in this arena remains poor. Studies examining medical therapy and endovascular and surgical revascularization were not designed to address sex disparities. Nevertheless, we dissect these therapies and their relevant randomized trials.SummaryThe paucity of data investigating the response of women to the different management options makes it difficult to make any evidence-based recommendations. This not only applies to the type of intervention, but also the appropriate timing and risks entailed.
Hierarchical controls on extinction selectivity across the diplobathrid crinoid phylogeny
Authors: Cole Selina R. 
Published: November 2019

AbstractIdentifying correlates of extinction risk is important for understanding the underlying mechanisms driving differential rates of extinction and variability in the temporal durations of taxa. Increasingly, it is recognized that the effects of multiple, potentially interacting variables and phylogenetic relationships should be incorporated when studying extinction selectivity to account for covariation of traits and shared evolutionary history. Here, I explore a variety of biological and ecological controls on genus longevity in the global fossil record of diplobathrid crinoids by analyzing the combined effects of species richness, habitat preference, body size, filtration fan density, and food size selectivity. I employ a suite of taxic and phylogenetic approaches to (1) quantitatively compare and rank the relative effects of multiple factors on taxonomic longevity and (2) determine how phylogenetic comparative approaches alter interpretations of extinction selectivity.I find controls on diplobathrid genus duration are hierarchically structured, where species richness is the primary predictor of duration, habitat is the secondary predictor, and combinations of ecological and biological traits are tertiary controls. Ecology plays an important but complex role in the generation of crinoid macroevolutionary patterns. Notably, tolerance of environmental heterogeneity promotes increased genus duration across diplobathrid crinoids, and the effects of traits related to feeding ecology vary depending on habitat lithology. Finally, I find accounting for phylogeny does not consistently decrease the significance of correlations between traits and genus duration, as is commonly expected. Instead, the strength of relationships between traits and duration may increase, decrease, or remain statistically similar, and both the magnitude and direction of these shifts are generally unpredictable. However, traits with strong correlations and/or moderately large effect sizes (Cohen'sf2> 0.15) under taxic approaches tend to remain qualitatively unchanged under phylogenetic approaches.
In vitro approach to evaluate the fermentation pattern of inulin-rich food in obese individuals
Authors: Kalala Gaétan , Kambashi Bienvenu , Taminiau Bernard , Schroyen Martine , Everaert Nadia , Beckers Yves , Richel Aurore , Njeumen Patrick , Pachikian Barbara , Neyrinck Audrey M. , Hiel Sophie , Rodriguez Julie , Fall Papa A. , Daube Georges , Thissen Jean-Paul , Delzenne Nathalie M. , Bindelle Jérôme 
Published: November 2019

AbstractAlterations of the gut microbiome have been associated with obesity and metabolic disorders. The gut microbiota can be influenced by the intake of dietary fibres with prebiotic properties, such as inulin-type fructans. The present study tested the hypothesis that obese individuals subjected for 12 weeks to an inulin-enriched v. inulin-poor diet have differential faecal fermentation patterns. The fermentation of cellulose and inulin hydrolysates of six different inulin-rich and inulin-poor vegetables of both groups was analysed in vitro on faecal inocula. The results showed that the microbiota from obese patients who received a fructan-rich diet for 3 weeks produces more gas and total SCFA compared with the microbiota taken from the same individuals before the treatment. Obese individuals fed with a low-fructan diet produce less gas and less SCFA compared with the treated group. The present study highlighted profound changes in microbiota fermentation capacity obtained by prebiotic intervention in obese individuals, which favours the production of specific bioactive metabolites.
A study of the use of post-operative opioid analgesics following rhinology surgery in 35 patients
Authors: Dodhia S , Patel S , Beghal G , Pandey K , Hopkins C 
Published: November 2019

AbstractObjectiveOpioid analgesics are often prescribed following rhinology surgery. This study aimed to evaluate whether the quantity of opioid analgesics prescribed is justified.MethodsPatients were asked about their pain management post-operatively. Parameters recorded included: current pain (using a 10-point Likert scale); type of operation; the opioid analgesics prescribed; and the quantity of opioid tablets taken and other methods of pain relief used.ResultsThirty-five patients were successfully contacted. The median pain score at one week post-operation was 1 (interquartile range, 0–3). Of these 35 patients, 16 were prescribed opioids, whilst 19 were not. Patients prescribed opioids took a median of 8 tablets (interquartile range, 0.8–10.5) out of the 28 tablets prescribed.ConclusionThe study shows that the quantity of post-operative opioid analgesics prescribed does not compare with the amount consumed by patients to relieve pain, resulting in a surplus of opioid medication which has the potential to be abused.
Global philosophy of religion(s)
Authors: HARRISON VICTORIA S. 
Published: November 2019

AbstractDrawing on the work of Mark Siderits, Jay Garfield, and others, I introduce a global approach to the philosophy of religion that is inspired by ‘fusion’, ‘engagement’, or ‘confluence’ philosophy. To globalize the philosophy of religion requires more than expanding its traditional disciplinary scope or broadening its range of questions; it requires philosophers who are conversant in more than one philosophical tradition. I argue that this approach offers a viable way to develop the discipline by providing a platform for deep and authentic engagement in philosophical inquiry that crosses traditional religious and philosophical boundaries.
Crop signal markers facilitate crop detection and weed removal from lettuce and tomato by an intelligent cultivator
Authors: Kennedy HannahJoy , Fennimore Steven A. , Slaughter David C. , Nguyen Thuy T. , Vuong Vivian L. , Raja Rekha , Smith Richard F. 
Published: November 2019

AbstractIncreasing weed control costs and limited herbicide options threaten vegetable crop profitability. Traditional interrow mechanical cultivation is very effective at removing weeds between crop rows. However, weed control within the crop rows is necessary to establish the crop and prevent yield loss. Currently, many vegetable crops require hand weeding to remove weeds within the row that remain after traditional cultivation and herbicide use. Intelligent cultivators have come into commercial use to remove intrarow weeds and reduce cost of hand weeding. Intelligent cultivators currently on the market such as the Robovator, use pattern recognition to detect the crop row. These cultivators do not differentiate crops and weeds and do not work well among high weed populations. One approach to differentiate weeds is to place a machine-detectable mark or signal on the crop (i.e., the crop has the mark and the weed does not), thereby facilitating weed/crop differentiation. Lettuce and tomato plants were marked with labels and topical markers, then cultivated with an intelligent cultivator programmed to identify the markers. Results from field trials in marked tomato and lettuce found that the intelligent cultivator removed 90% more weeds from tomato and 66% more weeds from lettuce than standard cultivators without reducing yields. Accurate crop and weed differentiation described here resulted in a 45% to 48% reduction in hand-weeding time per hectare.
The Ownership Effect in Dementia Patients
Authors: Blessing Andreas , Fritsche Sophie , Hess Charlotte , Dammann Gerhard 
Published: November 2019

Abstract. Ownership of objects influences memory performance in healthy subjects, a phenomenon referred to as the ownership effect. In dementia patients, memory performance is severely impaired, yet it is not known whether memory performance can be enhanced using the ownership effect. In this contribution we investigated the influence of ownership on memory performance in dementia patients, using an adapted shopping task to induce artificial ownership. Dementia patients ( N = 32) fictitiously owned half of the objects presented to them on picture cards. Memory performance was tested using a forced-choice recognition task that also included novel objects. Corrected hit rates of owned and previously unowned objects were compared using analysis of variance. The corrected hit rate for objects fictitiously owned by dementia patients was significantly higher than the hit rate for unowned objects ( p = .027; partial η2 = .152). Results indicate a significant memory enhancement for objects fictitiously owned by dementia patients. Our findings suggest that the memory performance of dementia patients can be influenced using the ownership effect, and that this effect could be used to design interventions that try to improve memory performance for relevant information in dementia patients.
Toward a Better Understanding of the Mindsets of	Negotiators
Authors: Ade Valentin , Dantlgraber Michael , Schuster Carolin , Trötschel Roman 
Published: November 2019

Abstract. This article introduces and discusses the 15-item Scale for the Integrative Mindset (SIM) of negotiators, that is of people involved in joint decision-making processes. The scale is based on the integrative mindset ( Ade, Schuster, Harinck, & Trötschel, 2018 ), which describes a set of three inclinations of parties approaching negotiations: a collaborative, a curious, and a creative one. Using a first sample ( N = 1,030) of online survey participants, we provide evidence for a high psychometric quality of the SIM as suggested by high reliabilities and good fit indices. We also compare the SIM with scales that measure well-known and possibly related psychological constructs and show the SIM’s distinction to them. Using a second sample ( N = 417), we show how the SIM differs from a Scale on Inappropriate Negotiation Strategies (SINS) that has been used in previous negotiation research. The findings of the present studies are discussed with respect to potential applications of the SIM in experimental research.
Predictive Properties and Factor Structure of the VRS-SO in an	Austrian Sample
Authors: Olver Mark E. , Eher Reinhard 
Published: November 2019

Abstract. We examined the structural and predictive properties of the Violence Risk Scale-Sexual Offense (VRS-SO) version in an Austrian sample of N = 666 men incarcerated for sexual offenses; 353 of whom were followed up an average of 11 years post-release. Results of a confirmatory factor analysis of dynamic item scores supported a three-factor model (Sexual Deviance, Criminality, and Treatment Responsivity) consistent with prior research. VRS-SO static, dynamic, and total scores showed good properties of discrimination for sexual (area under the receiver operating curve [AUC] = .68–.80) and violent (AUC = .65–.68) recidivism, while the factor scores showed differential prediction of these outcomes. Calibration analyses demonstrated lower estimated rates of 5-year sexual reoffense associated with VRS-SO score bands in the present sample compared to observed rates from the normative sample, with closest correspondence observed for the highest risk band (E/O index = 1.01). Implications for the psychometric properties and application of the VRS-SO in international settings are discussed.