bluuebunny/crossref_metadata_2025_split huggingface dataset:
Foldable All‐Textile Cavity‐Backed Slot Antennas for Personal UWB Localization
Authors: Van Baelen Dries , Van den Brande Quinten , Lemey Sam , Verhaevert Jo , Rogier Hendrik 
Published: February 2020

AbstractAn all‐textile multimoded cavity‐backed slot antenna has been designed and fabricated for body‐worn impulse radio ultra‐wideband (IR‐UWB) operation in the 3,744–4,742.4 MHz frequency band, thereby covering Channels 2 and 3 of the IEEE 802.15.4a standard. Its light weight, mechanical flexibility, and small footprint of 35 mm
56 mm facilitate integration into textile for radio communication equipment for first aid responders, personal locator beacons, and equipment for localization and medical monitoring of children or the elderly. The antenna features a stable radiation pattern and reflection coefficient in diverse operating conditions such as in free space, when subject to diverse bending radii and when deployed on the torso or upper right arm of a test person. The high isolation toward the wearer's body originates from the antenna's hemispherical radiation pattern with a
3 dB beamwidth of
and a front‐to‐back ratio higher than 11 dB over the entire band. Moreover, the antenna exhibits a measured maximum gain higher than 6.3 dBi and a radiation efficiency over
%. In addition, orientation‐specific pulse distortion introduced by the antenna element is analyzed by means of the System Fidelity Factor (SFF). The SFF of the communication link between two instances of this antenna is higher than 94% for all directions within the antenna's
3 dB beamwidth. This easily wearable and deployable antenna is suitable to support IR‐UWB localization with an accuracy in the order of 5 cm.
Stream and Spring Water Evolution in a Rapidly Urbanizing Watershed, Austin, TX
Authors: Beal Lakin , Senison Jeffrey , Banner Jay , Musgrove MaryLynn , Yazbek Lindsey , Bendik Nathan , Herrington Christopher , Reyes Daniel 
Published: February 2020

AbstractQuantifying urban development impacts on fresh water quality and quantity is critical, especially as growing populations concentrate in urban centers and with climate change projections of increased hydrologic extremes. We investigate geochemical processes through which municipal supply and waste water, carbonate bedrock, and soils impact stream and spring water compositions within the Bull Creek watershed (Austin, Texas). This watershed exhibits a sharp geographic divide between urban and rural land. Urban and rural waters were assessed to quantify relative influences of municipal water on stream and spring water elemental compositions and 87Sr/86Sr values. Higher 87Sr/86Sr for samples from urban sites relative to rural sites can be accounted for by two processes: (1) water leakage from municipal infrastructure and/or irrigation or (2) ion exchange as precipitation infiltrates through soils with varying 87Sr/86Sr. Irrigated soils have higher 87Sr/86Sr than unirrigated soils, indicating that irrigated municipal water resets soil compositions and that process (1) is a dominant driver of urban stream and spring water evolution. Geochemical modeling results indicate that urban waters consist of 50% to 95% municipal water. Geochemical modeling further demonstrates the evolution of municipal water as it infiltrates as groundwater and undergoes water‐rock interaction. These results are compared with groundwater compositions on a regional scale to infer local flow paths and relative groundwater residences times of municipal water. This study provides a geochemical modeling framework that quantifies both the significance of municipal water on urban stream water and soil compositions and the role of municipal water within urbanized watersheds and aquifers.
Thank You to Our Peer Reviewers for 2019
Authors: Florindo Fabio , Carlton Ann Marie , D'Odorico Paolo , Duan Qingyun , Halekas Jasper S. , Mollenhauer Gesine , Rohling Eelco J. 
Published: February 2020

Plain Language SummaryOn behalf of the authors and readers of Reviews of Geophysics (RoG), the American Geophysical Union (AGU), and the broader scientific community, the editors wish to wholeheartedly thank those who reviewed manuscripts for RoG in 2019.
Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis
Authors: Nabais Marta F. , Lin Tian , Benyamin Beben , Williams Kelly L. , Garton Fleur C. , Vinkhuyzen Anna A. E. , Zhang Futao , Vallerga Costanza L. , Restuadi Restuadi , Freydenzon Anna , Zwamborn Ramona A. J. , Hop Paul J. , Robinson Matthew R. , Gratten Jacob , Visscher Peter M. , Hannon Eilis , Mill Jonathan , Brown Matthew A. , Laing Nigel G. , Mather Karen A. , Sachdev Perminder S. , Ngo Shyuan T. , Steyn Frederik J. , Wallace Leanne , Henders Anjali K. , Needham Merrilee , Veldink Jan H. , Mathers Susan , Nicholson Garth , Rowe Dominic B. , Henderson Robert D. , McCombe Pamela A. , Pamphlett Roger , Yang Jian , Blair Ian P. , McRae Allan F. , Wray Naomi R. 
Published: February 2020

AbstractWe conducted DNA methylation association analyses using Illumina 450K data from whole blood for an Australian amyotrophic lateral sclerosis (ALS) case–control cohort (782 cases and 613 controls). Analyses used mixed linear models as implemented in the OSCA software. We found a significantly higher proportion of neutrophils in cases compared to controls which replicated in an independent cohort from the Netherlands (1159 cases and 637 controls). The OSCA MOMENT linear mixed model has been shown in simulations to best account for confounders. When combined in a methylation profile score, the 25 most-associated probes identified by MOMENT significantly classified case–control status in the Netherlands sample (area under the curve, AUC = 0.65, CI95% = [0.62–0.68], p = 8.3 × 10−22). The maximum AUC achieved was 0.69 (CI95% = [0.66–0.71], p = 4.3 × 10−34) when cell-type proportion was included in the predictor.
Click Inspired Synthesis of Novel Cinchonidine Glycoconjugates as Promising Plasmepsin Inhibitors
Authors: Mishra Nidhi , Agrahari Anand K. , Bose Priyanka , Singh Sumit K. , Singh Anoop S. , Tiwari Vinod K. 
Published: February 2020

AbstractAmong all the malaria parasites,P. falciparumis the most predominant species which has developed drug resistance against most of the commercial anti-malarial drugs. Thus, finding a new molecule for the inhibition of enzymes ofP. falciparumis the pharmacological challenge in present era. Herein, ten novel molecules have been designed with an amalgamation of cinchonidine, carbohydrate moiety and triazole ring by utilizing copper-catalyzed click reaction of cinchonidine-derived azide and clickable glycosyl alkynes. The molecular docking of developed molecules showed promising results for plasmepsin inhibition in the form of effective binding with target proteins.
Oligomerization and characteristics of phosphoenolpyruvate carboxylase in Synechococcus PCC 7002
Authors: Durall Claudia , Kanchugal P. Sandesh , Selmer Maria , Lindblad Peter 
Published: February 2020

AbstractPhosphoenolpyruvate carboxylase (PEPc) is an essential enzyme in plants. A photosynthetic form is present both as dimer and tetramer in C4 and CAM metabolism. Additionally, non-photosynthetic PEPcs are also present. The single, non-photosynthetic PEPc of the unicellular cyanobacterium Synechococcus PCC 7002 (Synechococcus), involved in the TCA cycle, was examined. Using size exclusion chromatography (SEC) and small angle X-ray scattering (SAXS), we observed that PEPc in Synechococcus exists as both a dimer and a tetramer. This is the first demonstration of two different oligomerization states of a non-photosynthetic PEPc. High concentration of Mg2+, the substrate PEP and a combination of low concentration of Mg2+ and HCO3− induced the tetramer form of the carboxylase. Using SEC-SAXS analysis, we showed that the oligomerization state of the carboxylase is concentration dependent and that, among the available crystal structures of PEPc, the scattering profile of PEPc of Synechococcus agrees best with the structure of PEPc from Escherichia coli. In addition, the kinetics of the tetramer purified in presence of Mg2+ using SEC, and of the mixed population purified in presence of Mg2+ using a Strep-tagged column were examined. Moreover, the enzyme showed interesting allosteric regulation, being activated by succinate and inhibited by glutamine, and not affected by either malate, 2-oxoglutarate, aspartic acid or citric acid.
Application of latent class analysis in diagnosis of graft-versus-host disease by serum markers after allogeneic haematopoietic stem cell transplantation
Authors: Amini Maedeh , Kazemnejad Anoshirvan , Rasekhi Aliakbar , Zayeri Farid , Hajifathali Abbas , Tavakoli Farzaneh 
Published: February 2020

AbstractGraft-versus-host disease (GVHD) is one of the major causes of morbidity and mortality in 25–70% of patients. The gold standard (GS) test to confirm the diagnosis of GVHD has some limitations. The current study was conducted to evaluate the accuracy of three serum markers in diagnosing GVHD without a GS. 94 patients who were hospitalized for allogeneic transplantation were studied. Mean levels from day of haematopoietic stem cell transplantation (HSCT) to discharge of serum uric acid (UA), lactate dehydrogenase (LDH), and creatinine (Cr) were measured for all participants. We adapted a Bayesian latent class analysis to modelling the results of each marker and combination of markers. The Sensitivity, Specificity, and area under receiver operating characteristic curve (AUC) for LDH were as 51%, 81%, and 0.70, respectively. For UA, the Sensitivity, Specificity, and AUC were 54%, 75%, and 0.71, respectively. The estimated Sensitivity, Specificity, and AUC of Cr were 72%, 94%, and 0.86, respectively. Adjusting for covariates, the combined Sensitivity, Specificity, and AUC of the optimal marker combination were 76%, 83%, and 0.94, respectively. To conclude, our findings suggested that Cr had the strongest diagnosis power for GVHD. Moreover, the classification accuracy of the three-marker combination outperforms the other combinations.
Chaos in the switched reluctance motor drive employing digital speed and current control
Authors: Li Sen , Moallem Mehdi , Balsara Poras T. , Fahimi Babak 
Published: February 2020

Adjustable speed motor drives are among the most representative types of non‐linear systems which can exhibit rich varieties of complex dynamic behaviours. This study presents the investigation of chaotic phenomena in the switched reluctance (SR) motor drive employing digital speed regulator and hysteresis current controller. For conducting stability analysis, a small signal discrete‐time model of the SR drive has been derived and analysed for a range of control parameters. The simulation results of time‐domain and frequency‐domain analysis and phase portraits of the SR drive system are also demonstrated and discussed. Two influencing factors for chaotic behaviour in the SR drive system are identified and examined in detail: the feedback delay of the speed regulator and measurement imperfection from a rotary incremental encoder. For verification, an 8/6 pole 2.3 kW SR drive is employed in experimental tests. The bifurcation diagrams of the reference signal, waveforms of phase current, and the corresponding frequency spectra are recorded and illustrated for both normal and chaotic operations, which reveal the pattern of chaos exhibited from this type of electric drive system.
Diagnosis of Left Ventricular Diastolic Dysfunction Using Cardiac Magnetic Resonance Imaging: Comparison of Volume-Time Curves Derived from Long- and Short-Axis Cine Steady-State Free Precession Datasets
Authors: Schaafs Lars-Arne , Wyschkon Sebastian , Elgeti Matthias , Nagel Sebastian Niko , Knebel Fabian , Steffen Ingo G. , Makowski Marcus R. , Hamm Bernd , Elgeti Thomas 
Published: February 2020

Purpose To evaluate the diagnostic performance of diastolic function parameters derived from long-axis (LAX) planimetry compared with short-axis (SAX) volumetry in cardiac magnetic resonance imaging.
Materials and Methods Cine steady-state free precession (SSFP) datasets of 15 healthy participants (8 young and 7 middle aged) and 25 patients with echocardiographically proven diastolic dysfunction (9 mild, 9 moderate, and 7 severe) were retrospectively included. Volume-time curves for assessing left ventricular (LV) function were obtained by manually contouring the LV endocardial borders in SAX and LAX datasets. The time needed for contouring was recorded for each dataset. The following LV parameters were determined: end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), myocardial mass (MM), time to peak filling rate (TPFR), normalized peak filling rate (nPFR), and the ratio of early to late peak filling rate (E/A ratio). A Wilcoxon signed-rank test was used to compare subgroups based on age and severity of diastolic dysfunction for statistical differences. Intraclass correlation coefficients were used to assess intermethod and interobserver reliability.
Results Accuracy for the diagnosis of diastolic dysfunction was highest for E/A (mild diastolic dysfunction) and nPFR (any stage of diastolic dysfunction) derived from LAX datasets (E/A: area under the curve (AUC) = 0.97, sensitivity of 68 % and specificity of 100 %; nPFR: AUC = 0.84, sensitivity of 84 % and specificity of 80 %). Diastolic parameters showed a moderate to good intraclass correlation between both methods. The mean differences in EDV, ESV, EF, and MM were 5.3 ml, 1.9 ml, 3.5 %, and 11 g, respectively (each p < 0.001). Significantly less time was needed to derive volume-time curves from LAX images (median 14:45 min, interquartile range 14:15–15:53 min versus median 29:25 min, interquartile range 28:12–32:22 min; p = 0.001). The interobserver reliability was generally good to excellent.
Conclusion Diastolic function parameters derived from left ventricular LAX planimetry have high diagnostic performance and can be obtained in significantly less time compared with SAX volumetry. These findings may pave the way for routine use of LAX planimetry in the clinical diagnosis of diastolic dysfunction.
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Der Lipödemschmerz und seine Folgen auf die Lebensqualität betroffener Patientinnen – Ergebnisse einer Patientenbefragung mittels Schmerzfragebogen
Authors: Gensior Matthias H.L. , Cornely Manuel 
Published: February 2020

ZusammenfassungBei 640 Patientinnen einer Fachklinik für operative Lymphologie erfolgte mittels Fragebogen der Deutschen Schmerzgesellschaft e. V. eine Befragung. Neben Fragen zum Schmerz und zur Schmerzcharakteristik wurden gleichzeitig noch demografische Daten miterhoben. Es ergab sich, dass nur bei etwas über 50 % eine echte Adipositas nachgewiesen werden konnte. Lipödem und Adipositas müssen als unabhängige Krankheitsbilder gewertet werden. Der Schmerz wurde überwiegend als drückend und ziehend empfunden. Attribute wie klopfend oder pochend, passend zu einer akuten Entzündung, erfuhren die Wertung „nicht zutreffend“. Die Beschwerdesymptomatik war unabhängig vom BMI, der bei der Lipohyperplasie dolorosa nur bedingt verwertbar ist. Insgesamt ist das Leitsymptom „Schmerz“ sehr facettenreich, das angeborene, nicht erworbene Lipödemfett der Extremitäten führt zu einer deutlichen Beeinträchtigung der Aktivitäten sowohl allgemein als auch im Freizeitbereich. Die durch den G-BA initiierte Studie muss daher kritisch gesehen werden. Da bislang keine objektivierbaren Befunde beim Lipödem erhoben werden können, ist eine subtile Befragung betroffener Patientinnen zur Diagnosestellung notwendig.
Lumbar Canal Stenosis: A Prospective Clinicoradiologic Analysis
Authors: Jain Nikhil , Acharya Shankar , Adsul Nitin Maruti , Haritwal Mukesh Kumar , Kumar Manoj , Chahal Rupinder Singh , Kalra Kashmiri Lal 
Published: February 2020

AbstractBackground Although spinal canal narrowing is thought to be the defining feature for the clinical diagnosis of lumbar canal stenosis, the degree of spinal canal stenosis necessary to elicit neurologic symptoms is not clear. Several studies have been performed to detect an association between a narrow spinal canal and clinical symptoms. Through our prospective study, we compared the radiologic criteria with the clinical criteria using the Oswestry Disability Index (ODI) and assessed how they correlate.Materials and Methods We used the qualitative grading (morphological classification system on magnetic resonance imaging [MRI]) system, dural sac cross-sectional area (DSCA), and sedimentation sign on MRI images and compared them with the Self-Paced Walking Ability (Self-Paced Walking Test) and ODI of the patients in the study. The systems were applied to 85 patients divided into three groups: group A: 43 patients with neurogenic claudication and able to walk < 30 minutes; group B: 11 patients with neurogenic claudication and able to walk > 30 minutes; and group C: 31 patients with simple back pain and no signs of neurologic claudication.Results The mean ODI was 21.19 in group C, 46.50 in group B, and 61.95 in group A. The difference was statistically significant. The mean DSCA was 164.42 mm2 in group C, 49.94 mm2 in group B, and 35.07 mm2 in group A. The difference was statistically significant. The sedimentation sign was negative in 96.8% patients in group C, 54.5% patients in group B, and 32.6% patients in group A. The difference was statistically significant. Group C had 9.3% patients in morphology grade A3, 51.6% in grade A2, and 38.7% patients in grade A1. Group B had 63.6% patients in grade C, 18.2% patients in grade B, 9.1% in grade A4, and 9.1% in grade A3. Group A had 18.6% patients in grade D, 39.5% in grade C, 27.9% in grade B, 11.6% in grade A4, and 2.3% in grade A3. The mean DSCA of group C was significantly different from group A and group B, but the difference of the mean DSCA between group A and group B was not statistically significant. The relationship of ODI to DSCA, ODI to sedimentation sign, and ODI to morphological grading for group C and group A was not statistically significant. The relationship of morphological grading to DSCA was statistically significant for all three groups.Conclusion DSCA, morphological grading, and sedimentation sign are good to excellent radiologic indicators differentiating patients with simple back pain from those with lumbar spinal stenosis. Clinically, ODI is an excellent indicator of the severity of stenosis. But ODI statistically has no significant correlation to any of these radiologic parameters.
Predisposição familiar para rotura do manguito rotador e outras tendinopatias – Um estudo de caso-controle
Authors: Assunção Jorge Henrique , Tenrreiro Breno Faria , Gracitelli Mauro Emilio Conforto , Malavolta Eduardo Angeli , Ferreira Neto Arnaldo Amado 
Published: February 2020

ResumoObjetivo Avaliar as prevalências de antecedente familiar de rotura do manguito e de tendinopatia em outras articulações em pacientes com rotura do manguito rotador e compará-las com controles pareados. Estimar a razão de chances de uma rotura do manguito rotador para estes dois fatores de risco.Métodos Realizamos um estudo de caso-controle comparando pacientes submetidos ao tratamento para rotura do manguito rotador com controles assintomáticos. Todos os casos e controles foram avaliados por exames de imagem e pareados por idade (±2 anos) e sexo. Realizamos uma entrevista utilizando um questionário padronizado, e coletamos dados referentes a vários fatores de risco.Resultados Avaliamos 144 pacientes, 72 por grupo. Os pacientes com rotura do manguito rotador relataram, em maior número, a presença de familiares consanguíneos que realizaram tratamento para a mesma doença e de lesões tendíneas em outras articulações em relação aos indivíduos controles (p = 0,005 e p = 0,045, respectivamente). Indivíduos com antecedente familiar de tratamento para rotura do manguito rotador ou com tendinopatias em outras articulações tiveram maior probabilidade de apresentar rotura do manguito rotador, com razões de chances de 3,3 (intervalo de confiança de 95% [IC95%] = 1,4–7,7) e 2,7 (IC95% = 1,1–6,9), respectivamente.Conclusões Os pacientes com rotura do manguito rotador têm maior prevalência de familiares com a mesma doença e de tendinopatias ou lesões tendíneas em outras articulações. A presença de familiares consanguíneos com tratamento para rotura do manguito rotador e tendinopatias em outras articulações são fatores de risco para presença de roturas do manguito rotador.
Lesão do tendão do músculo supraespinal e sua relação com a lesão do tendão da cabeça longa do bíceps
Authors: Carvalho Cassiano Diniz , Cohen Carina , Belangero Paulo Santoro , Pochini Alberto de Castro , Andreoli Carlos Vicente , Ejnisman Benno 
Published: February 2020

Resumo
Objetivo Identificar a correlação clínica, radiológica, e artroscópica das lesões do tendão da cabeça longa do bíceps e sua influência na dor do paciente quando associada às lesões do manguito rotador.
Métodos Entre abril e dezembro de 2013, foram avaliados 50 pacientes, sendo 38 (76%) do sexo feminino e 12 (24%) do sexo masculino, com idade média de 65,1 anos. Os pacientes foram operados pelo Grupo de Ombro e Cotovelo da Disciplina de Medicina Esportiva do Departamento de Ortopedia e Traumatologia da Universidade Federal de São Paulo. Os indivíduos foram submetidos a reparo da lesão do manguito rotador com evidência clínica, radiológica e/ou artroscópica de acometimento do tendão da cabeça longa do bíceps.
Resultados Observou-se associação entre dor à palpação do sulco intertubercular do úmero com lesão parcial de alto grau (ruptura parcial acometendo mais de 50% do tendão) na artroscopia (p = 0,003). Encontramos ainda uma associação entre a lesão de alto grau da cabeça longa do bíceps e a lesão do tendão do músculo supraespinal (p < 0,05), sendo que, para cada centímetro de lesão do tendão do músculo supraespinal, o paciente apresenta probabilidade 1,7 maior de ter uma lesão de alto grau da cabeça longa do bíceps.
Conclusão A dor na região anterior do ombro à palpação do sulco intertubercular do úmero pode estar relacionada às lesões de alto grau da cabeça longa do bíceps. A lesão do manguito rotador e o seu tamanho são fatores de risco para lesão de alto grau do tendão da cabeça longa do bíceps.
r-Epenthesis and the bigrade alternation
Authors: de Chene Brent 
Published: February 2020

Abstract
For Japanese verbal suffixes sensitive to the C/V status of the stem-final segment, C-stem alternants are underlying, and regular V-stem alternants result from intervocalic epenthesis of r at stem boundary (de Chene 2016). This “Analysis A” entails that any V-stem suffix not consisting of r plus its C-stem counterpart is irregular and subject to replacement. While the r-Epenthesis rule of Analysis A is naturally understood as a generalization of the r-zero alternation of three suffixes that have shown it since the eighth century, however, the innovative r-initial suffixes of other categories do not appear until the eighteenth. This lag is illuminated by the dialects of Kyūshū, where adoption of Analysis A is blocked by the “bigrade” stem alternation, which in most dialects was leveled in the seventeenth century. Building on a discussion of leveling that treats that phenomenon as a subtype of regularization, it is proposed in explanation of this “bigrade blocking” effect that the order in which alternations become subject to regularization is constrained by the phonological distance between alternants. Investigation of the possibility that the bigrade alternation and Analysis A are related by a triggering effect as well as by a blocking effect then leads to an account of the adoption of Analysis A that, similarly, relies crucially on the concept of phonological distance. Throughout, the focus is on the role of language-internal factors in determining the timing of analogical change.