bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiation Dose and Fluoroscopy Time of Endovascular Treatment in Patients with Intracranial Lateral Dural Arteriovenous Fistulae
Authors: Forbrig Robert , Stahl Robert , Geyer Lucas L. , Ozpeynirci Yigit , Liebig Thomas , Trumm Christoph G. 
Published: December 2020

Abstract
Purpose
Intracranial lateral dural arteriovenous fistula (LDAVF) represents a specific subtype of cerebrovascular fistulae, harboring a potentially life-threatening risk of brain hemorrhage. Fluoroscopically guided endovascular embolization is the therapeutic gold standard. We provide detailed dosimetry data to suggest novel diagnostic reference levels (DRL).

Methods
Retrospective single-center study of LDAVFs treated between January 2014 and December 2019. Regarding dosimetry, the dose area product (DAP) and fluoroscopy time were analyzed for the following variables: Cognard scale grade, endovascular technique, angiographic outcome, and digital subtraction angiography (DSA) protocol.

Results
A total of 70 patients (19 female, median age 65 years) were included. Total median values for DAP and fluoroscopy time were 325 Gy cm2 (25%/75% percentile: 245/414 Gy cm2) and 110 min (68/142min), respectively. Neither median DAP nor fluoroscopy time were significantly different when comparing low-grade with high-grade LDAVF (Cognard I + IIa versus IIb–V; p > 0.05, each). Transvenous coil embolization yielded the lowest dosimetry values, with significantly lower median values when compared to a combined transarterial/transvenous technique (DAP 290 Gy cm2 versus 388 Gy cm2, p = 0.031; fluoroscopy time 85 min versus 170 min, p = 0.016). A significant positive correlation was found between number of arterial feeders treated by liquid embolization and both DAP (rs = 0.367; p = 0.010) and fluoroscopy time (rs = 0.295; p = 0.040). Complete LDAVF occlusion was associated with transvenous coiling (p = 0.001). A low-dose DSA protocol yielded a 20% reduction of DAP (p = 0.021).

Conclusion
This LDAVF study suggests several local DRLs which varied substantially dependent on the endovascular technique and DSA protocol.
Impact of high carbon amendments and pre-crops on soil bacterial communities
Authors: Kamau Catherine W. , van Duijnen Richard , Schmid Christoph A. O. , Balàzs Helga E. , Roy Julien , Rillig Matthias , Schröder Peter , Radl Viviane , Temperton Vicky M. , Schloter Michael 
Published: December 2020

AbstractA 2-year outdoor mesocosm experiment was carried out to determine the effects of high C amendments (HCAs; wheat straw and sawdust) compared to a control with no addition of HCAs (no-HCA) and 2 different crop rotation systems (spring barley/winter barley and faba bean/winter barley) on soil bacterial communities using a molecular barcoding approach. Samples were analyzed after pre-crop harvest (T1) and harvest of winter barley (T2). Our data demonstrate a clear drop in bacterial diversity after winter barley harvest in the no-HCA and wheat straw treatment compared to the pre-crops. Sawdust application had a stabilizing effect on bacterial diversity compared to the pre-crops and induced an increase in carbon (C) stocks in soil which were however negatively correlated with yields. Main responders in the no-HCA and wheat straw treatment compared to the pre-crops were bacteria of the phyla Actinobacteria and Bacteroidetes which were enriched and bacteria belonging to Firmicutes, Gemmatimonadetes, Proteobacteria, and Gemmatimonadaceae which were depleted. Overall differences between wheat straw–amended and no-HCA control samples were small and included single ASVs from various phyla. In sawdust-amended samples, only a shift of some Proteobacteria families was observed compared to the no-HCA control. Overall, pre-crop plant species had small influence on the observed response pattern of the soil microbiome towards the amendments and was only visible for wheat straw.
Nicht einwilligungsfähige Patienten in der Intensiv- und Notfallmedizin
Authors: Klein Sebastian J. , Voithofer Caroline , Ganner Michael , Pixner Thomas , Valentin Andreas , Joannidis Michael 
Published: December 2020

ZusammenfassungIn Notfallsituationen bzw. in der Intensivmedizin ergibt sich oftmals das Problem, dass Patienten unvermittelt nur sehr eingeschränkt oder keine eigenen Entscheidungen treffen können. Das 2. Erwachsenenschutz-Gesetz (ErwSchG) hat das Erwachsenenschutzrecht (vormals „Sachwalterrecht“) neu geregelt, mit wichtigen Neuerungen in Bezug auf Einwilligungserfordernisse und Vertretungsmöglichkeiten von volljährigen Patienten, die selbst keine Entscheidungen mehr treffen können. Dieser Artikel soll die wichtigsten Änderungen und Neuerungen des ErwSchG darstellen und sich anhand von Fallbeispielen als Leitfaden für behandelnde Ärzte verstehen. Der Artikel bezieht sich ausschließlich auf die Rechtslage in Österreich.
Fast Flow Field Estimation for Various Applications with A Universally Applicable Machine Learning Concept
Authors: Leer Michael , Kempf Andreas 
Published: December 2020

AbstractThis paper presents an approach for the prediction of incompressible laminar steady flow fields over various geometry types. In conventional approaches of computational fluid dynamics (CFD), flow fields are obtained by solving model equations on computational grids, which is in general computationally expensive. Based on the ability of neural networks to intuitively identify and approximate nonlinear physical relationships, the proposed method makes it possible to eliminate the explicit implementation of model equations such as the Navier–Stokes equations. Moreover, it operates without iteration or spatial discretization of the flow problem. The method is based on the combination of a minimalistic multilayer perceptron (MLP) architecture and a radial-logarithmic filter mask (RLF). The RLF acts as a preprocessing step and its purpose is the spatial encoding of the flow guiding geometry into a compressed form, that can be effectively interpreted by the MLP. The concept is applied on internal flows as well as on external flows (e.g. airfoils and car shapes). In the first step, datasets of flow fields are generated using a CFD-code. Subsequently the neural networks are trained on defined portions of these datasets. Finally, the trained neural networks are applied on the remaining unknown geometries and the prediction accuracy is evaluated. Dataset generation, neural network implementation and evaluation are carried out in MATLAB. To ensure reproducibility of the results presented here, the trained neural networks and sample applications are made available for free download and testing.
Can Reminders of Rules Induce Compliance? Experimental Evidence from a Common Pool Resource Setting
Authors: Eisenbarth Sabrina , Graham Louis , Rigterink Anouk S. 
Published: December 2020

AbstractThis paper presents results from an RCT exploring whether a behavioural intervention can improve the conservation of a common pool resource. The literature on common pool resource management suggests that the existence of rules and sanctions is important to resource conservation. However, behavioural science suggests that individuals have finite cognitive capacity and may not be attentive to these rules and sanctions. This paper investigates the impact of an SMS message intervention designed to improve users’ knowledge of and attentiveness to existing forest use rules. An RCT in Uganda explores the impact of these messages on forest use and compliance with the rules. This paper finds that SMS messages raise the perceived probability of sanctions for rule-breakers. However, SMS messages do not induce full compliance with forest use rules or systematically reduce forest use.
The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders
Authors: Zhang Kaifan , Wang Yan , Fan Tianda , Zeng Cheng , Sun Zhong Sheng 
Published: December 2020

AbstractThe serine/threonine p21-activated kinases (PAKs), as main effectors of the Rho GTPases Cdc42 and Rac, represent a group of important molecular switches linking the complex cytoskeletal networks to broad neural activity. PAKs show wide expression in the brain, but they differ in specific cell types, brain regions, and developmental stages. PAKs play an essential and differential role in controlling neural cytoskeletal remodeling and are related to the development and fate of neurons as well as the structural and functional plasticity of dendritic spines. PAK-mediated actin signaling and interacting functional networks represent a common pathway frequently affected in multiple neurodevelopmental and neurodegenerative disorders. Considering specific small-molecule agonists and inhibitors for PAKs have been developed in cancer treatment, comprehensive knowledge about the role of PAKs in neural cytoskeletal remodeling will promote our understanding of the complex mechanisms underlying neurological diseases, which may also represent potential therapeutic targets of these diseases.
Correlation Between Financial Toxicity, Quality of Life, and Patient Satisfaction in an Insured Population of Breast Cancer Surgical Patients: A Single-Institution Retrospective Study
Authors: Coroneos Christopher J. , Lin Yu-Li , Sidey-Gibbons Chris , Asaad Malke , Chin Brian , Boukovalas Stefanos , Roubaud Margaret S. , Miggins Makesha , Baumann Donald P. , Offodile Anaeze C. 
Published: December 2020

BACKGROUND:
The relationship between treatment-related, cost-associated distress “financial toxicity” (FT) and quality-of life (QOL) in breast cancer patients remains poorly characterized. This study leverages validated patient-reported outcomes measures (PROMs) to analyze the association between FT and QOL and satisfaction among women undergoing ablative breast cancer surgery.

STUDY DESIGN:
This is a single-institution cross-sectional survey of all female breast cancer patients (>18 years old) who underwent lumpectomy or mastectomy between January 2018 and June 2019. FT was measured via the 11-item COmprehensive Score for financial Toxicity (COST) instrument. The BREAST-Q and SF-12 were used to asses condition-specific and global QOL, respectively. Responses were linked with demographic and clinical data. Pearson correlation coefficient and multivariable regression were used to examine associations.

RESULTS:
Our analytical sample consisted of 532 patients; mean age 58, mostly white (76.7%), employed (63.7%), married/committed (73.7%), with 64.3% undergoing reconstruction. Median household income was $80,000 to $120,000/year, and mean COST score was 28.0. After multivariable adjustment, a positive relationship for all outcomes was noted; lower COST (greater cost-associated distress) was associated with lower BREAST-Q and SF-12 scores. This relationship was strongest for BREAST-Q psychosocial well-being, for which we observed a 0.89 (95% CI 0.76–1.03) change per unit change in COST score.

CONCLUSIONS:
Financial toxicity captured in this study correlates with statistically significant and clinically important differences in BREAST-Q psychosocial well-being, patient satisfaction with reconstructed breasts, and SF-12 global mental and physical quality of life. Treatment costs should be included in the shared decision-making for breast cancer surgery. Future prospective outcomes research should integrate COST.
A Credibility-Backed Norm for Testimony
Authors: Weiner Matt 
Published: December 2020

AbstractI propose that testimony is subject to a norm that is backed by a credibility sanction: whenever the norm is violated, it is appropriate for the testifier to lose some credibility for their future testimony. This is one of a family of sanction-based norms, where violation of the norm makes it appropriate to lose some power; in this case, the power to induce belief through testimony. The applicability of the credibility norm to testimony follows from the epistemology of testimony, in that false or unjustified testimony weakens the reason for belief that is provided by the speaker's future testimony.
Maize grain and straw yields over 14 consecutive years in burned and mulched Mucuna pruriens var. utilis and Pueraria phaseoloides relay cropping systems
Authors: Hauser Stefan , Henrot Jacqueline , Korie Samuel 
Published: December 2020

AbstractThe cover crops Mucuna pruriens var. utilis and Pueraria phaseoloides were introduced to African farmers to improve crop production on degraded soils, yet they appear not to be adopted at scale. In the humid forest zone of West and Central Africa, the dominant Acrisols and Nitisols are inherently poor even when not degraded through agriculture. In this zone, sole maize cropping and vegetable production systems are gaining importance, yet both suffer from nutrient deficiencies. Cover crops were often introduced along with a system change, requiring biomass retention, mainly for nutrient retention reasons. Farmers in the zone commonly use slash and burn systems due to added weed control and ease of operations on clean fields. This study evaluated mucuna and pueraria with and without burning the fallow biomass in an annual sole maize crop relay system against the burned and retained natural fallow. Over 14 consecutive years, biomass burning did not cause lower maize grain yields in any of the fallow types, on the contrary, the economically important marketable cob yields were higher when biomass was burned (mulched 2.10 cobs m−2 vs. 2.26 cobs m−2 when burned, p < 0.07). After cover crop fallow, maize grain yields were significantly higher than after natural fallow (1.92 Mg ha−1) over the 14 years, with maize yields in the pueraria treatment (2.63 Mg ha−1) out yielding those in the mucuna treatment (2.28 Mg ha−1). Maize produced 1.92 cobs m−2 in natural fallow, significantly less than in the mucuna (2.23 m−2, p < 0.013) and the pueraria (2.39 m−2, p < 0.001) fallow. Introducing mucuna or pueraria cover crops into slash and burn systems appears as a suitable measure to increase yields without changing the land preparation approach.
Near-perfect clique-factors in sparse pseudorandom graphs
Authors: Han Jie , Kohayakawa Yoshiharu , Person Yury 
Published: December 2020

AbstractWe prove that, for any $t \ge 3$, there exists a constant c = c(t) > 0 such that any d-regular n-vertex graph with the second largest eigenvalue in absolute value λ satisfying $\lambda \le c{d^{t - 1}}/{n^{t - 2}}$ contains vertex-disjoint copies of kt covering all but at most ${n^{1 - 1/(8{t^4})}}$ vertices. This provides further support for the conjecture of Krivelevich, Sudakov and Szábo (Combinatorica24 (2004), pp. 403–426) that (n, d, λ)-graphs with n ∈ 3ℕ and $\lambda \le c{d^2}/n$ for a suitably small absolute constant c > 0 contain triangle-factors. Our arguments combine tools from linear programming with probabilistic techniques, and apply them in a certain weighted setting. We expect this method will be applicable to other problems in the field.
Errorless Psychomotor Training Modulates Visuomotor Behaviors Among Older Adults
Authors: Fan Mengjiao , Wong Thomson W. L. 
Published: December 2020

Abstract. This study investigated whether errorless psychomotor training with psychological manipulation could modify visuomotor behaviors in an everyday reaching motor task for older adults, and whether its benefits could be transferrable. A group of 36 older adults (mean age = 71.06, SD = 5.29) were trained on a reaching motor task (lifting a handled mug to a target) utilizing errorless, errorful, or normal psychomotor training. Results indicated that errorless psychomotor training decreased the reaching distance away from the target and the jerkiness of acceleration during the reaching task and transfer test. Errorless psychomotor training also reduced the duration of gaze fixation as well as horizontal and vertical eye activity. Our findings implicated that errorless psychomotor training could improve movement accuracy and alleviate movement variability during reaching by older adults.
Steep Glacier Bed Knickpoints Mitigate Inland Thinning in Greenland
Authors: Felikson Denis , A. Catania Ginny , Bartholomaus Timothy C. , Morlighem Mathieu , Noël Brice P. Y. 
Published: December 2020

AbstractGreenland’s outlet glaciers have been a leading source of mass loss and accompanying sea‐level rise from the Greenland Ice Sheet (GrIS) over the last 25 years. The dynamic component of outlet glacier mass loss depends on both the ice flux through the terminus and the inland extent of glacier thinning, initiated at the ice‐ocean interface. Here, we find limits to the inland spread of thinning that initiates at glacier termini for 141 ocean‐terminating outlet glaciers around the GrIS. Inland diffusion of thinning is limited by steep reaches of bed topography that we call “knickpoints.” We show that knickpoints exist beneath the majority of outlet glaciers but they are less steep in regions of gentle bed topography, giving glaciers in gentle bed topography the potential to contribute to ongoing and future mass loss from the GrIS by allowing the diffusion of thinning far into the ice sheet interior.
Hydrologic‐Economic Trade‐offs in Groundwater Allocation Policy Design
Authors: Young Richael , Foster Timothy , Mieno Taro , Valocchi Albert , Brozović Nicholas 
Published: December 2020

AbstractA common environmental externality of groundwater pumping is streamflow depletion. To manage impacts of groundwater pumping on hydrologically connected surface water systems, regulators often impose quotas, or allocations, limiting the rates of groundwater extraction. Allocations vary in their temporal flexibility, ranging from single‐year “hard caps” to multi‐year “soft caps”. Soft cap allocations allow greater flexibility for farmers, the primary users of groundwater, to adjust irrigation rates from one year to another, potentially providing greater resilience to drought but also altering hydrologic impacts of pumping. In this study, we integrate agronomic, economic, and hydrologic models to evaluate optimal irrigation decisions for a range of equivalent hard and soft cap limits, and assess trade‐offs between the resulting economic (farm profitability) and hydrologic (stream depletion) outcomes. Soft cap allocation policies consistently outperform equivalent hard caps in terms of greater farm profitability and reduced production risks. However, the economic benefits of soft caps come at the cost of higher peak and cumulative rates of streamflow depletion, with the magnitude of differences dependent on aquifer properties, well location, and the length of the soft cap allocation period. Our findings suggest that the optimal allocation design will depend on competing socioeconomic and environmental objectives, and, in some instances, may require a blended approach to efficiently achieve desired management goals.
Longitudinal pathways of cerebrospinal fluid and positron emission tomography biomarkers of amyloid-β positivity
Authors: Sala Arianna , Nordberg Agneta , Rodriguez-Vieitez Elena ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: December 2020

AbstractMismatch between CSF and PET amyloid-β biomarkers occurs in up to ≈20% of preclinical/prodromal Alzheimer’s disease individuals. Factors underlying mismatching results remain unclear. In this study we hypothesized that CSF/PET discordance provides unique biological/clinical information. To test this hypothesis, we investigated non-demented and demented participants with CSF amyloid-β42 and [18F]Florbetapir PET assessments at baseline (n = 867) and at 2-year follow-up (n = 289). Longitudinal trajectories of amyloid-β positivity were tracked simultaneously for CSF and PET biomarkers. In the longitudinal cohort (n = 289), we found that participants with normal CSF/PET amyloid-β biomarkers progressed more frequently toward CSF/PET discordance than to full CSF/PET positivity (χ2(1) = 5.40; p < 0.05). Progression to CSF+/PET+ status was ten times more frequent in cases with discordant biomarkers, as compared to csf−/pet− cases (χ2(1) = 18.86; p < 0.001). Compared to the CSF+/pet− group, the csf−/PET+ group had lower APOE-ε4ε4 prevalence (χ2(6) = 197; p < 0.001; n = 867) and slower rate of brain amyloid-β accumulation (F(3,600) = 12.76; p < 0.001; n = 608). These results demonstrate that biomarker discordance is a typical stage in the natural history of amyloid-β accumulation, with CSF or PET becoming abnormal first and not concurrently. Therefore, biomarker discordance allows for identification of individuals with elevated risk of progression toward fully abnormal amyloid-β biomarkers, with subsequent risk of neurodegeneration and cognitive decline. Our results also suggest that there are two alternative pathways (“CSF-first” vs. “PET-first”) toward established amyloid-β pathology, characterized by different genetic profiles and rates of amyloid-β accumulation. In conclusion, CSF and PET amyloid-β biomarkers provide distinct information, with potential implications for their use as biomarkers in clinical trials.
HPV E7-mediated NCAPH ectopic expression regulates the carcinogenesis of cervical carcinoma via PI3K/AKT/SGK pathway
Authors: Wang Meng , Qiao Xiaowen , Cooper Tamara , Pan Wei , Liu Liang , Hayball John , Lin Jiaxiang , Cui Xiujie , Zhou Yabin , Zhang Shule , Zou Ying , Zhang Ranran , Wang Xiao 
Published: December 2020

AbstractCervical cancer is one of the most common gynecological tumors in the world, and human papillomavirus (HPV) infection is its causative agent. However, the molecular mechanisms involved in the carcinogenesis of cervical cancer still require clarification. Here we found that knockdown of Non-SMC (Structural Maintenance of Chromosomes) condensin I complex subunit H (NCAPH) gene expression significantly inhibited the proliferation, migration, invasion and epithelial–mesenchymal transition (EMT) of cervical cancer cells in vitro, and restrained xenograft tumor formation in vivo. Intriguingly, HPV E7 could form a positive feedback loop with NCAPH. E7 upregulated NCAPH gene expression via E2F1 which initiated NCAPH transcription by binding to its promoter directly. Silencing of NCAPH reduced E7 transcription via promoting the transition of AP-1 heterodimer from c-Fos/c-Jun to Fra-1/c-Jun. Moreover, the E7-mediated NCAPH overexpression was involved in the activation of the PI3K/AKT/SGK signaling pathway. In vivo, NCAPH expression in cervical cancer tissues was significantly higher than which in normal cervix and high-grade squamous intraepithelial lesion (HSIL) tissues, and its expression was significantly correlated with tumor size, depth of invasion and lymph node metastasis. Patients with high NCAPH expression had a significantly better survival outcomes than those with low-expression, suggesting that NCAPH-induced cell proliferation might sensitize cancer cells to adjuvant therapy. In conclusion, our results revealed the role of NCAPH in the carcinogenesis of cervical cancer in vitro and in vivo. The interaction between E7 and NCAPH expands the mechanism of HPV induced tumorigenesis and that of host genes regulating HPV E7.