bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photoperiodic effects on monoamine signaling and gene expression throughout development in the serotonin and dopamine systems
Authors: Siemann Justin K. , Williams Piper , Malik Turnee N. , Jackson Chad R. , Green Noah H. , Emeson Ronald B. , Levitt Pat , McMahon Douglas G. 
Published: September 2020

AbstractPhotoperiod or the duration of daylight has been implicated as a risk factor in the development of mood disorders. The dopamine and serotonin systems are impacted by photoperiod and are consistently associated with affective disorders. Hence, we evaluated, at multiple stages of postnatal development, the expression of key dopaminergic (TH) and serotonergic (Tph2, SERT, and Pet-1) genes, and midbrain monoamine content in mice raised under control Equinox (LD 12:12), Short winter-like (LD 8:16), or Long summer-like (LD 16:8) photoperiods. Focusing in early adulthood, we evaluated the midbrain levels of these serotonergic genes, and also assayed these gene levels in the dorsal raphe nucleus (DRN) with RNAScope. Mice that developed under Short photoperiods demonstrated elevated midbrain TH expression levels, specifically during perinatal development compared to mice raised under Long photoperiods, and significantly decreased serotonin and dopamine content throughout the course of development. In adulthood, Long photoperiod mice demonstrated decreased midbrain Tph2 and SERT expression levels and reduced Tph2 levels in the DRN compared Short photoperiod mice. Thus, evaluating gene × environment interactions in the dopaminergic and serotonergic systems during multiple stages of development may lead to novel insights into the underlying mechanisms in the development of affective disorders.
Cross-sectional study of Staphyloccus lugdunensis prevalence in cats
Authors: Bierowiec Karolina 
Published: September 2020

AbstractStaphylococcus lugdunensis is a commensal bacterium in humans and other animals that can cause serious infections. The aim of this research was to estimate the frequency of S. lugdunensis in pet cats and to characterize the S. lugdunensis isolates obtained. The prevalence of S. lugdunensis was 0.77% (4/523) in healthy cats and 1.23% (1/81) in sick cats. The isolates (N = 5), which colonized conjunctival sacs, nares, and the anus, were almost fully phenotypically sensitive to antibiotics, but harbored resistance genes to four chemotherapeutic groups. Their sequence types (STs) included ST2, ST3, ST9, and ST15. There was detected a far lower prevalence of S. lugdunensis in pet cats than is reported in the human population. Nevertheless, the phenotypic and genotypic properties of S. lugdunensis isolates found in the current study were very similar to those described previously in isolates of human origin.
Magneto-mechanically actuated microstructures to efficiently prevent bacterial biofilm formation
Authors: Leulmi Pichot S. , Joisten H. , Grant A. J. , Dieny B. , Cowburn R. P. 
Published: September 2020

AbstractBiofilm colonisation of surfaces is of critical importance in various areas ranging from indwelling medical devices to industrial setups. Of particular importance is the reduced susceptibility of bacteria embedded in a biofilm to existing antimicrobial agents. In this paper, we demonstrate that remotely actuated magnetic cantilevers grafted on a substrate act efficiently in preventing bacterial biofilm formation. When exposed to an alternating magnetic field, the flexible magnetic cantilevers vertically deflect from their initial position periodically, with an extremely low frequency (0.16 Hz). The cantilevers’ beating prevents the initial stage of bacterial adhesion to the substrate surface and the subsequent biofilm growth. Our experimental data on E. coli liquid cultures demonstrate up to a 70% reduction in biofilm formation. A theoretical model has been developed to predict the amplitude of the cantilevers vertical deflection. Our results demonstrate proof-of-concept for a device that can magneto-mechanically prevent the first stage in bacterial biofilm formation, acting as on-demand fouling release active surfaces.
Highly efficient gene transfer in the mouse gut microbiota is enabled by the Incl2 conjugative plasmid TP114
Authors: Neil Kevin , Allard Nancy , Grenier Frédéric , Burrus Vincent , Rodrigue Sébastien 
Published: September 2020

AbstractThe gut microbiota is a suspected hotspot for bacterial conjugation due to its high density and diversity of microorganisms. However, the contribution of different conjugative plasmid families to horizontal gene transfer in this environment remains poorly characterized. Here, we systematically quantified the transfer rates in the mouse intestinal tract for 13 conjugative plasmids encompassing 10 major incompatibility groups. The vast majority of these plasmids were unable to perform conjugation in situ or only reached relatively low transfer rates. Surprisingly, IncI2 conjugative plasmid TP114 was identified as a proficient DNA delivery system in this environment, with the ability to transfer to virtually 100% of the probed recipient bacteria. We also show that a type IV pilus present in I-complex conjugative plasmids plays a crucial role for the transfer of TP114 in the mouse intestinal microbiota, most likely by contributing to mating pair stabilization. These results provide new insights on the mobility of genes in the gut microbiota and highlights TP114 as a very efficient DNA delivery system of interest for microbiome editing tools.
Data-Informed Guideposts for Decision Making in Enhanced Conversational Recast Treatment
Authors: Hall Jessica , Plante Elena 
Published: September 2020

Background
To maximize treatment efficiency, it would be useful to determine how long to continue a treatment approach before concluding that it is not effective for a particular client, whether and when generalization of treatment is likely to occur, and at what point to end treatment once a child is approaching mastery.

Method
We analyzed aggregate data from 117 preschoolers with developmental language disorder from a decade of treatment studies on Enhanced Conversational Recast therapy to determine whether the timing of treatment response impacts its overall effectiveness and whether certain levels of accuracy during treatment enable 100% accurate generalization after treatment ends.

Results
We found that children who take longer than 10 days to answer one item correctly during treatment are unlikely to ever respond to the treatment approach. Generalization accuracy closely followed treatment accuracy, suggesting the two are tightly linked for this treatment method. We did not find evidence that attaining a certain level of accuracy below 100% during treatment enabled children to generalize with 100% accuracy after treatment ended.

Conclusions
Clinicians using Enhanced Conversational Recast treatment can use these markers to help make evidence-based decisions in their practice regarding how long to continue treatment. Importantly, these data suggest that stopping treatment before a child has attained 100% accuracy (for at least three sessions) does not ensure that a child will ever reach 100% accuracy on their own.
Design, analysis, and implementation of a new high step‐up DC–DC converter with low input current ripple and ultra‐high‐voltage conversion ratio
Authors: Jabarullah Noor Hafidzah , Geetha Ettikkan , Arun Manoharan , Vakhnina Vera 
Published: September 2020

In this study, the analysis and design of a coupled‐inductor (CL)‐based ultra‐high step‐up single‐switch DC–DC converter are presented. With the aid of the CL and voltage multiplier cell, the suggested topology can obtain ultra‐high‐voltage gain without a large turn ratio and extreme duty cycle. A passive clamp circuit is utilised in the structure of the introduced converter for not only alleviating voltage spike on the main switch effectively but also recycle the leakage inductance energy. So low‐voltage rating and low on‐state resistance metal oxide semiconductor field‐effect transistor is allowed to increase efficiency and lower the conduction losses. The input current ripple of the suggested topology is very low due to connecting an inductor to the suggested structure input section, which is very friendly and desirable to the photovoltaic and fuel cell applications. The suggested converter steady‐state analysis, operation principle, theoretical efficiency analysis, and design procedure are described comprehensively in this study. Furthermore, the suggested converter superiority is illustrated over various alike recently introduced the most important DC–DC structures in the comparison study. Finally, a laboratory prototype is fabricated with a 225 W output power to confirm the theoretical analysis of the introduced converter.
Strangeness Photoproduction at the BGO-OD experiment
Authors: Jude Thomas , Alef Stefan , Bauer Patrick , Beck Reinhard , Braghieri Alessandro , Cole Philip , Di Salvo Rachele , Elsner Daniel , Fantini Alessia , Freyermuth Oliver , Ghio Francesco , Gridnev Anatoly , Hammann Daniel , Hannappel Jürgen , Kohl Katrin , Kozlenko Nikolay , Lapik Alexander , Levi Sandri Paolo , Lisin Valery , Mandaglio Giuseppe , Messi Roberto , Moricciani Dario , Nedorezov Vladimir , Novinsky Dmitry , Pedroni Paolo , Polonski Andrei , Reitz Björn-Eric , Romaniuk Mariia , Scheluchin Georg , Schmieden Hartmut , Sumachev Victorin , Tarakanov Viacheslav , Tillmanns Christian 
Published: September 2020

The BGO-OD experiment at the ELSA accelerator facility uses an energy tagged bremsstrahlung photon beam to investigate the excitation structure of the nucleon. The setup consists of a highly segmented BGO calorimeter surrounding the target, with a particle tracking magnetic spectrometer at forward angles.BGO-OD is ideal for investigating low momentum transfer processes due to the acceptance and high momentum resolution at forward angles. In particular, this enables the investigation of strangeness photoproduction where t-channel exchange mechanisms play an important role. This also allows access to low momentum exchange kinematics where extended, molecular structure may manifest in reaction mechanisms.First key results at lowtindicate a cusp-like structure inK+Σ0photoproduction atW =1900 MeV, line shapes and differential cross sections for K+Λ(1405)→K+Σ0π0, and a peak structure inK0SΣ0photoproduction. The peak in theK0SΣ0channel appears consistent with meson-baryon generated states, where equivalent models have been used to describe thePCpentaquark candidates in the heavy charmed quark sector.
Exploring time like tranistions in pp, πp and AA reactions with HADES
Authors: Salabura Piotr , Adamczewski-Musch J. , Arnoldi-Meadows B. , Belounnas A. , Belyaev A. , Blanco A. , Blume C. , Böhmer M. , Borisenko S , Chlad L. , Chudoba P , Ciepał I. , Dittert D. , Dreyer J. , Esmail W. , Dürr M. , Fabbietti L. , Fateev S. , Fonte P. , Friese J. , Fröhlich I. , Förtsch J. , Galatyuk T. , Gernhäuser R. , Golosov O. , Golubeva M. , Greifenhagen R. , Guber F. , Gumberidze M. , Harabasz S. , Hensch R. , Höhne C. , Holzmann R. , Huck H. , Ierusalimov A. , Ivashkin A. , Kämpfer B. , Kampert K-H. , Kardan B. , Koenig I. , Koenig W. , Kornakov G. , Kornas F. , Kotte R. , Kozela A. , Kres I. , Kuboś J. , Kugler A. , Kulesa P. , Ladygin V. , Lalik R. , Lebedev A. , Lebedev S. , Linev S. , Lopes L. , Lorenz M. , Lykasov G. , Mahmoud T. , Malige A. , Markert J. , Matulewicz T. , Maurus S. , Metag V. , Michel J. , Morozov S. , Müntz C. , Naumann L. , Nowakowski K. , Otto J.-H. , Patel V. , Pauly C. , Pechenov V. , Pechenova O. , Petukhov O. , Pfeifer D. , Piasecki K. , Pietraszko J. , Prozorov A. , Przygoda W. , Pysz K. , Ramstein B. , Rathod N. , Reshetin A. , Ritman L. , Rodriguez-Ramos P. , Rost A. , Salabura P. , Scozzi F. , Seck F. , Selyuzhenkov I. , Shabanov I. , Singh US , Smyrski J. , Spies S. , Ströbele H. , Stroth J. , Stumm J. , Svoboda O. , Szala M. , Tlusty P. , Traxler M. , Ungethüm C. , Vazquez-Doce O. , Wagner V. , Weber A.A. , Wendisch C. , Wiebusch M.G. , Wintz P. , Wirth J. , Zhilin A. , Zumbruch P. 
Published: September 2020

Radiative transition of an excited baryon to a nucleon with emission of a virtual massive	photon converting to dielectron pair (Dalitz decays) provides important	information	about baryon-photon coupling at low q2 in timelike region. A prominent enhancement in the respective electromagnetic transition Form Factors (etFF) at q2 near vector mesons ρ/ω poles has been predicted by various calculations reflecting strong baryon-vector meson couplings. The understanding of these couplings is also of primary importance for the interpretation of the emissivity of QCD matter studied in heavy ion collisions via dilepton emission. Dedicated measurements of baryon Dalitz decays in proton-proton and pion-proton scattering with HADES detector at GSI/FAIR are presented and discussed. The relevance of these studies for the interpretation of results obtained from heavy ion reactions is elucidated on the example of the HADES results.
Study of pp → 𝚵+ ΛK- with the PANDA Detector
Authors: Pütz Jennifer , Gillitzer Albrecht , Ritman James , Stockmanns Tobias 
Published: September 2020

For a deeper insight into the mechanisms of non-perturbative QCD it is essential to understand the excitation pattern of baryons. Up to now only the nucleon excitation spectrum has been subject to systematic experimental studies, while very little is known on excited states of double or triple strange baryons.
In studies of antiproton-proton collisions the PANDA experiment is well-suited for a comprehensive baryon spectroscopy program in the multi-strange sector. A large fraction of the inelastic pp cross section is associated to final states with a baryon-antibaryon pair together with additional mesons, giving access to excited states both in the baryon and the antibaryon channel.
For final states containing a 𝚵+ 𝚵- pair, cross sections up to µb are expected, corresponding to production rates of ~ 106/d at a luminosity L = 1031 cm-2 s-1. This study focuses on excited 𝚵- states decaying into ΛK-. A strategy to reconstruct the reaction pp → 𝚵+ 𝚵* and its charge conjugate channel with the PANDA detector will be presented.
Endoscopic ultrasound-guided through-the-needle microforceps biopsy improves diagnostic yield for pancreatic cystic lesions: a systematic review and meta-analysis
Authors: McCarty Thomas , Rustagi Tarun 
Published: September 2020

AbstractBackground and study aims Given variable diagnostic yield of endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) for pancreatic cystic lesions (PCLs), a through-the-needle (TTN) microforceps biopsy device passed through a 19-gauge FNA needle has been devised to improve tissue sampling. This was a systematic review and meta-analysis to evaluate the feasibility, diagnostic yield, and safety of EUS-guided TTN microforceps biopsy for diagnosis of PCLs.Methods Individualized searches were developed in accordance with PRISMA and MOOSE guidelines. This was a cumulative meta-analysis performed by calculating pooled proportions with rates estimated using random effects models. Measured outcomes included pooled technical success, diagnostic yield, accuracy, and procedure-associated adverse events (AEs) as well as comparison to conventional FNA.Results Eleven studies (n = 518 patients; mean age 64.13 ± 5.83 years; 58.19 % female) were included. Mean PCL size was 33.39 ± 3.72 mm with the pancreatic head/uncinate (35.50 %) being the most common location. A mean of 2.47 ± 0.92 forceps passes were performed with a mean of 2.79 ± 0.81 microbiopsies obtained per lesion. Pooled technical success was 97.12 % (95 % CI, 93.73–98.71; I2 = 34.49) with a diagnostic yield of 79.60 % (95 % CI, 72.62–85.16; I2 = 56.00), and accuracy of 82.76 % [(95 % CI, 77.80–86.80; I2 = 0.00). The pooled serious adverse event rate was 1.08 % (95 % CI, 0.43–2.69; I2 = 0.00). Compared to conventional FNA, TTN microforceps biopsy resulted in significant improvement in diagnostic yield [OR 4.79 (95 % CI: 1.52–15.06; P = 0.007)] and diagnostic accuracy [OR 8.69 (95 % CI, 1.12–67.12; P = 0.038)], respectively.Conclusions EUS-guided TTN microforceps biopsy appears to be safe and effective for diagnosis of PCLs with improvement in diagnostic yield and accuracy when compared to FNA alone.
Was wissen wir über Demenz?
Authors: Scheel Jennifer , Gräßel Elmar , Donath Carolin 
Published: September 2020

SummaryDie Versorgung von Menschen mit Demenzstellt Medizin und Wissenschaft vor einegroße Herausforderung. Da bis heute keinekurative Arzneimitteltherapie zur Verfügungsteht, kommt nichtpharmakologischen Präventions- und Therapiestrategien eine bedeutendeRolle zu. Ziel des Projekts „Opti-Dem“ – Optimierungsstrategien bei Demenz:Forschung zu Prävention, Therapieund Versorgung war es, das aktuelle Wissenüber Demenz in einer Forschungsplattformzu bündeln und zu bewerten und so die Vorbeugung, Behandlung und Versorgung vonMenschen mit Demenz zu verbessern.
Endoscopic submucosal dissection and tunneling procedures using a novel all-in-one bipolar device
Authors: Nabi Zaheer , Chavan Radhika , Ramchandani Mohan , Tsiamoulos Zacharias , Basha Jahanqeer , Goud Rajesh , Darisetty Santosh , Reddy Nageshwar 
Published: September 2020

Abstract
Background and study aims Recent innovations in devices and techniques have revolutionized the field of endoscopic resection procedures. In this study, we evaluated the safety and feasibility of endoscopic submucosal dissection and tunneling procedures with a novel, multipurpose bipolar device.
Patients and methods Data from consecutive patients who underwent per-oral endoscopic myotomy (POEM), submucosal tunneling endoscopic resection (STER), and endoscopic submucosal dissection (ESD) using a novel bipolar device (December 2019 to February 2020) were analyzed retrospectively. Procedure duration, technical success, and adverse events (AEs) were recorded.
Results A total of 10 procedures were performed using the novel bipolar device during the study period. The procedures included POEM (n = 7), STER for esophageal sub-epithelial tumor (n = 1), ESD for rectal polyp (n = 1), and gastric neuroendocrine tumor (n = 1). POEM was successfully completed in all patients. In patients who underwent STER and ESD, en-bloc resection was achieved in all. Mean procedure time for submucosal tunneling procedures (POEM and STER) was 59.12 ± 31.12 minutes. The procedures were completed without the requirement for exchange of accessories in eight cases (80 %). There were no major AEs. Mild and moderate AEs occurred during POEM and included capno-peritoneum (n = 1), retroperitoneal CO2 (n = 1), and empyema (n = 1).
Conclusion ESD and tunneling procedures can be safely performed without the need for exchange of accessories using a novel bipolar device. Randomized comparison with conventional knives isrequired to confirm the utility of this device.
Is sore throat an underreported and under-estimated quality indicator for endoscopic procedures? Results from a large prospective cohort
Authors: Kim Katherine , Gaddam Srinivas , Verula John , Lai Ellis , Dollentas Ashley , Hill Bee , Francis Sarah , Chess Shara , Lo Simon 
Published: September 2020

AbstractBackground and study aims Patients often develop sore throat after upper endoscopy procedures but there data are very limited on the magnitude of the problem. The aim of this study was to evaluate and identify independent risk factors of sore throat in patients undergoing endoscopy.Patients and methods Data were collected prospectively on consecutive outpatient endoscopy procedures performed at Cedars-Sinai Medical Center from October 2018 to February 2019. Procedure nurses collected pre-procedure, intra-procedure, and immediate post-procedure surveys including evaluation of sore throat (pain scale from 1 – 10). Significant univariate variables (P < 0.05) were entered into a multivariate logistic regression model.Results Data were collected on 715 patients. Four hundred seventy-two patients (mean age = 61 years, females = 53 %) were included in the analysis and 85 patients (18 %) experienced post-procedure sore throat. On univariate analysis, female gender, oral endoscopic ultrasound (EUS), oral double balloon enteroscopy (DBE), fellow involvement, throat suctioning, general anesthesia, oral airway, and prolonged procedure (> 30 minutes) were risk factors for sore throat (all P < 0.05). On the multivariate analysis, independent risk-factors for post-procedure sore throat were oral DBE (odds ratio [OR] 5.2), oral airway (OR 4.8), general anesthesia (OR 2.7), fellow involvement (OR 2.5), oral EUS (OR 2.4), and female gender (OR 2.0).Conclusions Contrary to popular belief, our study found that post-procedural sore throat is more common (18 %) than previously reported. Two types of endoscopic procedures, two anesthesia maneuvers, female gender, and fellow involvement were all independent risk factors. This is of particular concern for interventionalists who perform EUS and oral DBE as these patients are at higher risk for sore throat.
Spermidin als Demenzprotektor
Authors: Madeo Frank , Eisenberg Tobias 
Published: September 2020

SummarySpermidin ist eine natürliche im Organismus vorkommendeSubstanz des Aminosäurestoffwechsels. In Untersuchungenkonnte eine Aktivierung der Autophagiedurch Spermidin gezeigt werden. Dieser zelluläre Recyclingprozesswird v.a. durch Fasten ausgelöst und hatbelegte gesundheitsfördernde Wirkungen.Experimentelle und klinische Studien geben vielversprechendeHinweise für einen möglichen Einsatz von Spermidinzur Demenzprävention. Eine klinische Studiekonnte eine Korrelation des Spermidinspiegels mit derkognitiven Leistungsfähigkeit zeigen. Eine weitere Untersuchungdeutet auf eine verbesserte Gehirngesundheitbei Spermidinaufnahme mit der Nahrung hin.Weitere Untersuchungen sind notwendig, um das Potenzialdieser körpereigenen Substanz insbesondere zurProtektion von Demenzerkrankungen zu erhärten.
Der alte Mensch in der Akupunkturpraxis
Authors: Wuttke Britta 
Published: September 2020

SummaryStützen und stärken lauten die Schlüsselwörterder chinesischen Medizin beim altenMenschen. Schlafstörungen, Herzschwäche, Schmerzen, aber auch Ängste und Schwächekönnen mit Akupunktur und Ernährung gelindertwerden. Die Funktionskreise Milzund Niere bilden die Basis der Behandlung.Die Autorin stellt bewährte Akupunkturpunktebei häufigen Beschwerden im Altervor, ergänzt durch Ernährungsempfehlungenauf der Grundlage der TraditionellenChinesischen Medizin.