bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Differentiated Approach Effectiveness in Patients with Varying Degrees of Severity of Chronic Ocular Ischemic Syndrome Caused by Internal Carotid Artery Stenosis
Authors: Tuzlaev V. V. , Egorov V. V. , Kravchenko I. Z. , Smoliakova G. P. 
Published: April 2020

Purpose: to study the effect of differentiated treatment approach in patients with varying degrees of severity chronic ocular ischemic syndrome (OIS) on clinical course of disease and hemodynamics of eyes in prospective research.Patients and methods. The research included 20 patients with chronic OIS. Patients were divided into 4 groups due to severity of chronic OIS and type of treatment. 1st group — 7 patients with moderate severity chronic OIS and hemodynamically significant of internal carotid artery stenosis (ICAS); only carotid endarterectomy (CE) of ICAS was performed. 2nd group — 6 patients with severe degree chronic OIS and hemodynamically significant stenosis of ICAS; 2 weeks before CE, panretinal photocoagulation (PRP) of retinal capillary non-perfusion areas was performed. 3rd group — 4 patients with severe degree chronic OIS, complicated by rubeosis iris and increased IOP on hypotensive regimen, on the background of hemodynamically insignificant ICAS; PRP of retina was performed. 4th group — 3 patients with moderate severity chronic OIS with hemodynamically insignificant ICAS; course of neuroprotective therapy was performed. All patients underwent standard and specialized ophthalmologic examination methods. Assessment of blood flow in brachiocephalic vessels, eye vessels was performed by ultrasound scan, spiral computed tomography, OCT-angiography with the AngioVue.Results. Monitoring of patients’ groups for 1 year after chronic OIS treatment allowed us to determine tactics of patient management depending on degree of ICAS and severity of chronic OIS. Reconstructive surgery at hemodynamically significant ICAS caused positive dynamic in intraocular blood flow, which contributed to improvement and preservation of BCVA in 71 % of patients. Preventive PRP of retina, before performing reconstructive surgery of ICAS, optimized and reduced the time of visual recovery. PRP of retina as independent method of treatment of chronic OIS, complicated by neovascular glaucoma, caused full or partial regression of neovascularization in iris, which increased possibilities of its effective treatment. Neuroprotective pharmacotherapy in early stages of chronic OIS, in absence of indications for reconstructive surgery and PRP of retina, improved the prognosis for patients’ vision.Conclusion. Differentiated treatment approach in patients with chronic OIS, due to changes of hemodynamics of internal carotid artery, has improved indexes of hemodynamic and visual acuity.
Features of Monitoring Patients with Primary and Advanced Stages of Glaucoma in Krasnodar Territory
Authors: Apostolova A. S. , Malyshev A. V. , Gurdzhijan K. M. , Shipilov V. A. , Ponomareva N. N. 
Published: April 2020

Purpose: to analyze the monitoring of patients with primary and advanced stages of glaucoma, who applied to the private clinic “Tri-Z” (Krasnodar).Patients and Methods. A total of 3 524 patients underwent screening with a diagnosis of glaucoma for all over 2018 at the clinic, of which 55.6 % were diagnosed with primary and advanced glaucoma. The criterion for inclusion in the study was primary glaucoma of the initial and advanced stages, elimination criteria: high degree of refraction errors, retinal detachment in anamnesis, proliferative diabetic retinopathy, AMD exudative forms, congenital forms of glaucoma, secondary types of glaucoma.Results: The average age of patients was 68.44 ± 8.142 years, women were 71 %, men — 29 %. The average duration of glaucomatous history was 3.48 ± 3.525 years. POAG was found in 85.3 % of cases, PACG in 14.7 % of cases. Glaucoma without concomitant PEX was observed in 44.7 % cases, with signs of PEX in 55.3 % cases. In stage I of glaucoma, the majority of patients (42.7 %) received APG and in 27.1 % cases a fixed combination of ICA + BB. In stage II glaucoma, the majority of patients (26.5 %) received a fixed combination of ICA + BB, in 18.8 % of cases, the combination of APG + ICA + BB and in 17.7 % — APG. The share of laser interventions: LTP — 14.7 %, SLT — 4.1 %, peripheral iridectomy — 10 %, YAG-GP — 0.8 %, SLT + YAG-GP — 0.8 %, peripheral iridectomy + SLT — 0.5 %. The share of surgical interventions: at glaucoma stage I non-penetrating deep sclerectomy (NPDS) — 3.4 %; at stage II NPDS — 10.9 %, repeated NPDS — 0.5 %, deepsclerectomy — 2.2 %; phacoemulsification + IOL — 21.9 % of cases.Conclusion: In the study, we noted the following features: use, including as a starting therapy, effective drugs or their combinations; the preferred use of fixed combinations; prioritization of non-preservative therapy; high frequency of laser interventions in the anterior eye segment; use of peripheral laser iridectomy in the overwhelming majority of cases when PACG is detected; early transition to surgical treatment.
Comparison of the Clinical Efficacy of Draining Autovalve Limbosclerectomy and Trabeculectomy in the Treatment of Primary Open-Angle Glaucoma with Long-Term Follow-Up
Authors: Lapochkin D. V. , Lapochkin V. I. , Lapochkin A. V. 
Published: April 2020

Purpose: to evaluate the immediate and long-term hypotensive efficacy, the number of complications, and the clinical benefits of a draining autovalve limbosclerectomy (DALS) performed using a kit of disposable instruments in patients with POAG of various stages in comparison with trabeculectomy (TE).Patients and Methods. The study is based on the analysis of the clinical and functional condition of 127 eyes of 127 patients with primary open-angle glaucoma (stage I POAG was detected in 2 eyes, stage II in 30 eyes, stage III in 88 eyes and stage IV in 7 eyes). Patients were divided into groups: the main group—76 people who underwent DALS using a set of disposable instruments, and the control group—51 people who underwent TE. The average age of patients is 68.9 ± 10.3 years. Before and within 24 months after surgery, all patients underwent standard diagnostic examinations. The initial level of IOP against the background of the maximum antihypertensive mode varied from 24 to 50 mm. Hg. According to gonioscopy, the angle of the anterior chamber was open in all cases (III–IV degree). Patient exclusion criteria: history of laser or surgical treatment of glaucoma, cataract treatment.Results. After 24 months of follow-up after DALS, the level of IOP in patients with stage I–II of POAG was 14.19 ± 1.83 mm Hg and with III–IV stage of POAG 14.95 ± 2.15 mm Hg, compensation was achieved in 88.2 % of patients without the use of antihypertensive drops. After TE, compensation was received in 72.6 % of patients, the IOP level was 16.9 ± 2.21 and 17.78 ± 2.31 mm Hg. respectively (p < 0.01). After DALS surgery, a decrease in the number of complications was revealed in comparison with TE: a decrease in сiliochoroidal detachment by 9.1 %, hyphema by 2.5 %, ophthalmic hypertension in the early p/o period by 3.2 %, cystic changes in the filtering bleb by 7.1 %.Conclusion. The standardized DALS operation using a disposable tool kit is a new highly effective and safe method for the surgical treatment of glaucoma. DALS may be the operation of choice in the treatment of POAG of all stages.
Retinal Postphotoreceptor Layers and Macular Electroretinogram in Retinitis Pigmentosa
Authors: Zolnikova I. V. , Milash S. V. , Chernyak A. B. , Levina D. V. , Egorova I. V. , Rogatina E. V. , Eremeeva E. A. , Rogova S. Y. 
Published: April 2020

Purpose: to assess the inner retinal layer’s changes of the central retina in comparison with bioelectrical activity of macula assessed by MERG and with thickness of photoreceptor retinal layers in patients with retinitis pigmentosa.Patients and methods: 10 patients (20 phakic eyes) with RP were examined. Mean age was 27.0 ± 18.5 years. Mean best corrected visual acuity was 0.38 ± 0.22. The fundus photography electrophysiological studies were performed besides standard ophthalmological examination. Maximal electroretinogram (ERG) or cone-rod response, ERG to 30 Hz flicker and macular ERG were registered with electroretinograph MBN (Russia). Images were acquired using the protocol of scanning Macula radial (12 lines 9 mm long, each radial image is the average out of 50 scans) with settings ultrafine with automatic segmentation of the retina and calculation thickness. Retinal segmentation with the following calculation of different retinal layers was performed on SD-OCT RS-3000 Advance (Nidek, Japan) with obtainment of the map with 6 mm in diameter in accordance with the Early Treatment Diabetic Retinopathy Study (ETDRS).Results. We revealed increased thickness of retinal nerve fiber layer (RNFL), decrease of thickness of ganglion cell layer (GCL) (p < 0,05) and normal (p > 0,05) inner nuclear layer (INL) thickness. These structural changes are associated with the decrease of bioelectric macula’s activity measured by MERG (decrease of α- and β-wave amplitude) and decrease the thickness of photoreceptor layers in all zones according to EDTRS.Conclusion. Increase of thickness RNFL, decrease of GCL’s thickness and normal INL in patients with RP is associated with decrease of thickness of photoreceptor layers in EDTRS zones and decrease of amplitude of MERG.
Predictors of Early Retinal Changes in Diabetes Mellitus
Authors: Kulybysheva V. S. , Ronzina I. A. , Gamidov A. A. , Motalov V. G. , Nikolenko V. N. 
Published: April 2020

Purpose. Determining the functional state of the outer and inner retina’s layers in patients with diabetes mellitus (DM) type 1 and 2 before the clinical manifestations and in the early stages of diabetic retinopathy (DR) using the methods of multifocal electroretinography (mfERG) and microperimetry (MP).Patients and methods. 91 patients were examined (182 eyes). The patients were divided into 4 groups: 1st — 23 people (46 eyes) with diabetes without DR (the duration of the disease is up to 2 years); 2nd — 22 people (44 eyes) with diabetes without DR (diabetes from 2 to 8 years); 3rd — 24 people (48 eyes) with NPDR on the background of diabetes; 4th — 22 people (44 eyes) of the control group (healthy eyes). In addition to the standard ophthalmologic examination, all patients were registered mfERG (FOK1) on the diagnostic equipment EP-1000 Multifocal (Tomey, Germany) and carried out MP using the device “MAIA” (CenterVue, Italy).Results. According to mfERG, it has been established that the components of mfERG, the biopotential density and the amplitude of P1, are most sensitive to diabetic changes. In groups with type 1 and type 2 diabetes, there is a significant decrease in the density of P1 in comparison with the control group (p < 0.005, Mann-Whitney test), as well as a decrease in the amplitude of P1 on almost all tested rings (p < 0.005). In all groups, there is an increase in the latency of P1 in the central ring (0–2.3°). According to MP data, it was found that patients with type 1 and type 2 diabetes showed a decrease in the average light sensitivity in comparison with the control group, however, our data are within the reference values, regardless of the presence or absence of clinical manifestations of PD.Conclusion. As a result of the study, early functional and morphological disorders of the neurosensory apparatus of the eye in diabetes were identified. It is proved that mfER and MP allow to detect violations at the preclinical stage of DR and are necessary studies for the dynamic control of the progression of DR.
Circular Sympathetic Pulmonary Artery Denervation in Cardiac Surgery Patients With Mitral Valve Defect, Atrial Fibrillation and High Pulmonary Hypertension
Authors: Trofimov N. A. , Medvedev A. P. , Babokin V. Y. , Efimova I. P. , Kichigin V. A. , Dragunov A. G. , Nikolskii A. V. , Tabaev R. G. , Preobrazenskii A. I. 
Published: April 2020

ObjectiveInvestigate the influence of the sympathetic denervation of the pulmonary trunk and the orifices of the pulmonary arteries on the degree of pulmonary hypertension (PH) and outcomes of the surgical treatment of atrial fibrillation (AF) in patients with mitral valve defects, complicated AF, and high PH.Material and methodsWe analyzed the surgical treatment of 140 patients with mitral valve defect, concomitant AF, and high PH – pulmonary artery systolic pressure (PASP) gradient more than 40 mm Hg. The group of interest included 51 patients (46 patients with severe mitral stenosis and five patients with grade 4 mitral valve regurgitation). All patients underwent mitral valve correction (47 valve replacement surgeries and 4 valve-sparing interventions), biatrial Maze IV procedure, and additionally, denervation of the pulmonary trunk and the orifices of the pulmonary arteries. The control group included 89 patients diagnosed with mitral valve defect, AF, and PH with PASP > 40 mm Hg. However, unlike in patients of interest, denervation of the pulmonary arteries was not performed.ResultsCircular radiofrequency denervation of the pulmonary trunk and the orifices of the pulmonary arteries using a clamp-destructor is an effective and safe method, significantly reduces secondary PH (p=0.018), promotes reverse remodeling of the heart chambers, left atrium in particular (p=0.01), and improves outcomes of the Maze IV procedure (p=0.022) by restoring sinus rhythm in patients with mitral valve defects, complicated AF, and high PH.ConclusionThis technique must be studied further involving a more significant number of patients, analyzing long-term results, and using this technique in patients with non-valvular causes of secondary PH.
Lifestyle Modification as a Method of Treatment of Vasovagal Syncope
Authors: Kuchinskaya E. A. , Pevzner A. V. 
Published: April 2020

Vasovagal syncope is the most common cause for loss of consciousness. The need for treatment of this condition is warranted by impaired quality of life and a risk of trauma due to the fall. At present, there are no medications with proven preventive effectiveness for vasovagal syncope as demonstrated by large randomized, placebo-controlled studies. At the same time, information about the pathogenesis of vasovagal reaction and provoking factors allows effective use of non-drug methods (such as patient education, physical exercise, maneuvers) in the management of patients with vasovagal syncope.
The Relationship between Nurses Knowledge Management and Organizational Culture in Teaching Hospitals of Iran University of Medical Sciences
Authors: Donyayi Nasrin , Mohammad Zadeh Naser 
Published: April 2020

Introduction: Today, use of knowledge management components can be changed by altering the nurses' organizational culture. The purpose of this study was to investigate the relationship of knowledge management with organizational culture of nurses working in teaching hospitals of Iran University of Medical Sciences.
Methods: This descriptive correlational study was conducted over all nurses working in teaching hospitals affiliated to Iran University of Medical Sciences in 2016. The population size was estimated as 85. The data collection tools included two questionnaires. Organizational culture questionnaire of Quinn model and knowledge management questionnaire of Lawson model. Data analysis was performed using SPSS version 16.
Results: The analysis showed that the components of knowledge management was associated with all aspects of organizational culture. The correlation between knowledge management and organizational culture was 0.4-0.7. the significant level was set at p≤ 0.005.
Conclusion: The nurses' knowledge management was significantly correlated with organizational culture and all its components. By programming in dimensions of organizational culture, nurses' interactions within the organization can be improved so that knowledge management can be institutionalized as a superior advantage in the educational centers.
Determining and Rating Environmental Aspects caused by the Production Process of Oxygenating Machine, Infectious Wastes Disinfection Device, and an Autoclave System with an Emphasis on Fuzzy AHP
Authors: Damnei Nazanin , Babaei Farzam , Dana Touraj 
Published: April 2020

Introduction: The medical device industry plays a special role in promoting the health and safety of the community. Its proper and optimal management can also significantly affect the national development of any country in terms of economics, health, medical education, and research. The present study attempted to evaluate the impact of environmental aspects of the medical device manufacturing unit on the environmental quality of the project by examining the impact of activities, production process, equipment, services, and the coefficient of action.
Methods: This descriptive-analytic study was conducted with a practical purpose. To identify the environmental aspects in the process of producing oxygenators, infectious waste disinfection device, and autoclave system, the EFMEA method, severity of the environmental consequence, probability of its occurrence, and probability of its discovery were applied using the Fuzzy AHP method.
Results: The results showed that the RPN was at its highest value of 160 before the control measures. This was due to the excessive energy consumption and air pollutant emission, which reached 40 after taking the control measures. In the process of manufacturing the above-mentioned apparatus, it was found that the welding activity in the production process of normal weight oxygenator was 0.223. The staining activity in the production process of wastes disinfection device with a normal weight of 0.216 and thewelding activity in the autoclave production process with a normal weight of 0.187 had the highest environmental priority.
Conclusion: According to the results, environmental aspects differ in various devices and we cannot generalize the results by periodization of one device.
Epidemiological, Clinical and Paraclinical Study of the Reported Cases of Tuberculosis in Qaemshahr (2010-2017)
Authors: Babamahmoudi Farhang , Razavi Alireza , Hessami Amirhossein , Heydari Foroogh , Hosseinzadegan Mohsen , Najafi Narges , Soleymani Eissa , Davoodi Lotfollah 
Published: April 2020

Introduction: Tuberculosis (TB) is a chronic, life-threatening, and contagious infectious. This study aimed to evaluate the epidemiological, clinical, and paraclinical findings of TB in Qaemshahr.Material and Methods: In this descriptive cross-sectional study, we investigated all patients with TB who had registered and existing data from 2010 to 2017. Demographical data, clinical and paraclinical characteristics including family history of disease, disease type (pulmonary and extrapulmonary), smear and culture results, underlying disease, chest X-ray results were extracted from records. Data were collected and analyzed using SPSS version 22.Results: Out of 290 patients, 61.4% were male (178 cases), and 38.6% (112 cases) were female. The mean age was 21.75 ± 21.25 years. 70.7% were pulmonary, and 29.3% were extrapulmonary. 60.3% were in urban areas and 39.7% in rural areas. The largest organ involved was lung (70.7%). 95.5% were diagnosed as new. The smear was negative in 53.8% of patients. 44.8% of patients were smear-positive. The culture result was positive in 54.5% of patients with TB. In the case of bronchoalveolar lavage (BAL), smear, 11.7% of patients had a positive result. The negative result of BAL smear was observed in 88.3% of cases.Conclusion: Awareness of various forms and clinical symptoms, radiographic findings in people with TB help to early detection of the disease.
Ecossistema de inovação em plataformas de aplicativos
Authors: Giovanini Adilson , Bittencourt Pablo Felipe , Uriona Maurício 
Published: April 2020

As plataformas de aplicativos fazem parte de ecossistemas de inovação, onde as interações entre usuários finais e desenvolvedores autorregulam o crescimento do próprio ecossistema. Uma das informações mais importantes para esse processo são as avaliações dos usuários. Com o intuito de analisar o impacto dessas informações, este artigo utiliza uma regressão por mínimos quadrados ordinários (MQO) para o ano de 2016, com base em 19 variáveis para 60 países. É mensurado o grau de exigência do mercado consumidor, utilizando um novo indicador baseado nas avaliações dos usuários finais para verificar a consistência de relações entre qualidade da demanda (mensurada pelo novo indicador) e o desempenho inovador de diferentes países nesse segmento. Os resultados evidenciam a robustez e as novas possibilidades de pesquisa que surgem, dadas as características positivas apresentadas pelo novo indicador construído através da utilização de ferramentas de big data e data analytics. Esse indicador mostra que a qualidade da demanda apoia inovações no segmento produtivo, o que levou à concussão de que obter feedback da demanda mais sofisticada representa um estímulo potencial poderoso ao avanço no desenvolvimento de aplicativos.
Pedagogy 21 Century from Perspective Information and Communication Technology (ICT): The Application in Learning
Authors: Razali Hazrul Affendi Mohmad 
Published: April 2020

<p><span lang="EN-US">The use of <em>Information and Communication Technology</em> (ICT) has provided great benefits in many fields including education. Lifestyle changes and the need to make the teaching and learning process more interesting and effective have driven the application of ICT in teaching. This paper aims to explain the influence of teacher knowledge and the process of implementing ICT in teaching. This process of implementing ICT requires teachers to be constantly aware and competitive with the changes that occur in teaching and learning. The impact of this paper is the change in teachers 'attitudes towards the need for ICT applications in teaching and teachers' thinking to cope with ever-changing technology.</span></p><p> </p><p> </p>
High Order Thinking Skill and Literacy Base Technological Pedagogical Content Knowledge (TPACK) in Order to Improve Students Learning Quality of in Job Primary School Teacher’s Proffesional Educational Program
Authors: Hartati Tatat , Heryanto Dwi , Annisa Nuri , Nuriyanti Risma , Saputra Alpin Herman , Sutedi Rahmat 
Published: April 2020

<p>Quality of learning by teachers nowadays, have not became a serious focus of interest. As the result, the quality of the graduate student is at low rate. The purpose of this research is to develop and apply <em>Technology Pedagogical Content Knowledge </em>(TPACK) for the Injob Primary School Professional Educational Teacher Program (PPG dalam jabatan). The methods applied on the study were combination of qualitative and quantitative and R&amp;D by 4D outline modification, they are; define, design, develop, and disseminate. The subjects of the study are 42 students of The Student of the Injob Teacher of Professional Educational Program which divided into two class of control and experiments each within 21 students. The result of the study is a TPACK model base on literacy and high order thinking skill with significance of the pretest and posttest achievement at 0.001, which indicates that literacy base TPACK model and high order thinking skill effects to the quality of the Injob Teacher Professional Educational Program learning as the student experience Literacy base TPACK model and high order thinking skill learning.</p>
Analis Pengembangan Modul Pembelajaran Berbasis Reciprocal Teaching Pair Share
Authors: Widyaningrum Diyah Ayu , Wahyuni Lila 
Published: April 2020

This study aim determined the profile analysis of module needed based on Recripocal Teaching Pair Share learning model on Protist and Fungi material. The location used retrieved data was Taman Madya Malang High School. The method used in this study was the collection of qualitative descriptive data with an instrument in the form of a questionnaire to teachers and students. The resulted showed that teachers and students agreed with the development of Recripocal Teaching Pair Share (RTPS) based modules.