bluuebunny/crossref_metadata_2025_split huggingface dataset:
RNA-seq analysis and compound screening highlight multiple signalling pathways regulating secondary cell death after acute CNS injuryin vivo
Authors: Herzog Chiara , Greenald David , Larraz Juan , Keatinge Marcus , Herrgen Leah 
Published: May 2020

ABSTRACTUnderstanding the molecular mechanisms that regulate secondary cell death after acute central nervous system (CNS) injury is critical for the development of effective neuroprotective drugs. Previous research has shown that neurotoxic processes including excitotoxicity, oxidative stress and neuroinflammation can cause secondary cell death. Nevertheless, clinical trials targeting these processes have been largely unsuccessful, suggesting that the signalling pathways underlying secondary cell death remain incompletely understood. Due to their suitability for live imaging and their amenability to genetic and pharmacological manipulation, larval zebrafish provide an ideal platform for studying the regulation of secondary cell death in vivo. Here, we use RNA-seq gene expression profiling and compound screening to identify signalling pathways that regulate secondary cell death after acute neural injury in larval zebrafish. RNA-seq analysis of genes upregulated in cephalic mpeg1+ macrophage-lineage cells isolated from mpeg1:GFP transgenic larvae after neural injury suggested an involvement of cytokine and polyamine signalling in secondary cell death. Furthermore, screening a library of FDA approved compounds indicated roles for GABA, serotonin and dopamine signalling. Overall, our results highlight multiple signalling pathways that regulate secondary cell death in vivo, and thus provide a starting point for the development of novel neuroprotective treatments for patients with CNS injury.This article has an associated First Person interview with the two first authors of the paper.
Changes in Firefighter Weight and Cardiovascular Disease Risk Factors over Five Years
Authors: MATHIAS KEVIN C. , BODE EMILIE D. , STEWART DONALD F. , SMITH DENISE L. 
Published: May 2020

ABSTRACT

Purpose
This study aimed to assess changes in cardiovascular disease (CVD) risk factors in firefighters who lost, maintained, or gained weight over 5 yr.

Methods
Anthropometrics and biomarkers of CVD were measured during two occupational medical exams 4.8 yr apart in 656 career firefighters. Weight change subgroups were loss (decrease of >3% body weight), stable (within ±3% body weight), and gain (increase of >3% body weight). Changes in CVD risk factors in the total sample and within weight change subgroups were tested for statistical significance using paired t-tests.

Results
After 5 yr, 12% of the sample lost weight, 38% maintained weight, and 50% gained weight. Firefighters on average had significant increases (P < 0.001) in body weight (2.5 ± 0.2 kg), body mass index (0.8 ± 0.1 kg·m−2), total cholesterol (5.5 ± 1.4 mg·dL−1), LDL cholesterol (5.2 ± 1.2 mg·dL−1), and blood glucose (2.1 ± 0.5 mg·dL−1). Firefighters who gained weight (6.6 ± 0.2 kg) had significant increases (P < 0.001) in total cholesterol (12.9 ± 1.8 mg·dL−1), LDL cholesterol (11.1 ± 1.6 mg·dL−1), and blood glucose (2.9 ± 0.7 mg·dL−1) with a significant decrease (P ≤ 0.01) in HDL cholesterol (−1.3 ± 0.4 mg·dL−1). Firefighters who lost weight (−7.2 ± 0.5 kg) had significant decreases (P < 0.05) in total cholesterol (−8.5 ± 3.9 mg·dL−1), LDL cholesterol (−6.7 ± 3.3 mg·dL−1), and blood pressure (systolic: −5.3 ± 1.3 mm Hg; diastolic −4.2 ± 1.0 mm Hg) with a significant increase (P < 0.05) in HDL cholesterol (2.3 ± 1.0 mg·dL−1).

Conclusions
Although improvements in cardiovascular health among firefighters who lost weight were found, 50% of the sample gained weight with adverse changes in measures of cardiovascular health. Given that sudden cardiac death is the most common cause of duty-related death among firefighters, with increased risk among obese firefighters, the amount of weight gain and the adverse changes in cardiovascular health suggest the need for improvements in health promotion programs for firefighters in the United States.
Barriers and facilitators to the implementation of nutrition standards for school food: a mixed methods systematic review protocol
Authors: O'Mahony Breda , Kerins Claire , Murrin Celine , Kelly Colette 
Published: May 2020

Background: The importance of nutrition during childhood and the high prevalence of child and adolescence obesity has resulted in several countries implementing nutritional standards for school food as a way of providing healthy school food environments. Yet there has been less focus on the barriers and facilitators influencing the process of implementing school food standards. This mixed methods systematic review aims to address this evidence gap by synthesising the empirical evidence on the factors that may influence implementation of school food standards. Methods: This mixed methods systematic review will use qualitative, quantitative and mixed methods evidence from peer reviewed publications retrieved from the following databases; PubMed, CINAHL, Scopus, EMBASE, PsycINFO and Web of Science. Grey literature will be accessed through Google Scholar, Open Access Theses and Dissertations, OpenGrey, RIAN, EThOS, ProQuest, WorldCat, Networked Digital Library of Theses and Dissertations, and public health organisation websites will also be accessed. Screening reference lists and citation chaining of all included studies will also be undertaken. No restrictions on publication date or language will be applied, however, only primary research studies relevant to supply-side stakeholders will be eligible for inclusion. Study quality will be assessed using the Mixed Methods Appraisal Tool. Study titles and abstracts will be screened to decide whether the full text manuscript should be retrieved. For screening reliability, a second review author will assess a random sample of 20%. Kappa statistics will be used to assess inter-rater reliability, with values of 0.75 and higher representing high agreement. Two authors will independently extract data and factors reported to influence implementation. This will be synthesized using the Theoretical Domains Framework. Discussion: A comprehensive understanding of these factors can provide guidance to relevant stakeholders to enhance the adaption, implementation and sustainability of nutrition standards for school meals. Systematic review registration: PROSPERO CRD42019117904
Rapid and precise compensation of scale factor in a fiber-optic gyroscope with a twin-peaks source
Authors: Wu Weiran , Xian Tuohua , Hu Guodong , Zhou Kejiang 
Published: May 2020

In this Letter, two gyro outputs containing identical rotation rates are produced by a twin-peaks light source with peak wavelengths of 1530 nm and 1560 nm. We demonstrate that the two outputs’ ratio

κ

can compensate for the temperature-induced scale factor drift in an interferometric fiber-optic gyroscope (IFOG). When the temperature ranged from

−

10
∘

C

to 50°C, the scale factor drift after compensation was about 30 times less than that before compensation, and the minimum drift was

±

7.7

p
p
m

at the rotation rate of 100°/s.
Deuterated silicon dioxide for heterogeneous integration of ultra-low-loss waveguides
Authors: Jin Warren , John Demis D. , Bauters Jared F. , Bosch Tony , Thibeault Brian J. , Bowers John E. 
Published: May 2020

Ultra-low-loss waveguide fabrication typically requires high-temperature annealing beyond 1000°C to reduce the hydrogen content in deposited dielectric films. However, realizing the full potential of an ultra-low loss will require the integration of active materials that cannot tolerate high temperature. Uniting ultra-low-loss waveguides with on-chip sources, modulators, and detectors will require a low-temperature, low-loss dielectric to serve as a passivation and spacer layers for complex fabrication processes. We report a 250°C deuterated silicon dioxide film for top cladding in ultra-low-loss waveguides. Using multiple techniques, we measure propagation loss below 12 dB/m for the entire 1200–1650 nm range and top-cladding material absorption below 1 dB/m in the S, C, and L bands.
Bibliofármacos: Subversiones Poéticas de la Medicina a través de la Palabra
Authors: Climent Espino Rafael 
Published: May 2020

Al hablar de libro, solemos referirnos a un formato específico, el del códex; sin embargo, este es solo uno entre muchos posibles. El auge del códex por razones prácticas condenó a la desaparición a una variedad importante de formatos textuales y homogenizó las formas de vehicular textos. Así, se relegó, e incluso se condenó a la desaparición, a una gran variedad de transmisores textuales. Este estudio vindica en primer lugar la inclusión en los estudios literarios de aquellos textos editados en formatos distintos al códice. En segundo lugar, centra el análisis en objetos-libro relacionados con la medicina. Tomando la palabra – logos – en su sentido clásico como remedio, propongo el término bibliofármacos para referirme a una serie de libros presentados en forma de medicinas – cajas de pastillas, botes de cápsulas, etc. – producidos y escritos por poetas y artistas españoles del siglo XXI. Su lectura tiene la intención de convertirse en una práctica terapéutica personal y social. Finalmente, se señala que el soporte de la escritura potencia las posibilidades de los usos de ese objeto-libro cargando de connotaciones el texto que transmite. Esa conjunción entre escritura, objeto y medicina crea una sinergia que ofrece al lector un singularísimo objeto literario.
DOI: https://doi.org/10.14195/2182-8830_7-1_10
An Affinity of Intellectual Liveliness: A Conversation with Hans Ulrich Gumbrecht
Authors: Waki Fábio , Sabino Ana 
Published: May 2020

Interview with Hans Ulrich Gumbrecht at the Faculty of Letters of the University of Coimbra, conducted by Fábio Waki and Ana Sabino on April 12, 2019. The conversation comprises many aspects of Gumbrecht's work, but is focused on the idea of materiality and a non-hermeneutical analysis of literature.
DOI: https://doi.org/10.14195/2182-8830_7-1_12
Entre Lisboa e Ingatestone: Revue Ou e Esboços para uma Arqueologia da Poesia Sonora em Portugal
Authors: Neves Nuno Miguel 
Published: May 2020

A Revue OU-Cinquème Saison é justamente considerada como uma das mais representativas publicações no âmbito das poéticas experimentais. Publicada entre 1958 e 1974, ao longo de mais de 40 números, ela foi palco de um conjunto extenso de relações entre autores das mais variadas origens e correntes poéticas. A correspondência enviada por E. M. de Melo e Castro e J. A da Silva a Henri Chopin, bem como a circulação material realizada entre eles, serão assim motivo para um artigo que procura explorar, a partir desta rede, a arqueologia da poesia sonora portuguesa e da poesia sonora em Portugal.
DOI: https://doi.org/10.14195/2182-8830_7-1_2
Photography as a Writing Machine: Notes on Christian Dotremont’s Logoneiges
Authors: González Arantxa Romero 
Published: May 2020

In 1963, Christian Dotremont began to contrive his “logoneiges” during a trip across Lapland, artworks which take to the limit the “logogrammes”, creations between calligraphy and verse. Here the white of the paper is replaced with the infinite whiteness of Lapland’s landscape. Indeed, the “logoneige” would disappear if a “second writing” were not added: the photographs themselves. By analyzing alongside Roland Barthes and Jacques Derrida, with the writings of Dotremont, we propose that photography is, in the “logoneiges”, not only a mere whitness but a writing tool, that re-produces the poetic sense. We want to develop this multiple time that creates even triple writings compared with “logogrammes”, attempting to prove the poetical reach of this singular machine.
DOI: https://doi.org/10.14195/2182-8830_7-1_5
Pantalla y Papel: Materialidad Digital y Materialidad Análoga en Plagio del Afecto de Carlos Cociña
Authors: Andrade Kobayashi Megumi 
Published: May 2020

Plagio del afecto (2003-2005/2010) del poeta chileno Carlos Cociña (1950–) está compuesto a partir de textos apropiados de diversas fuentes. El libro fue publicado en formato digital en la página web del autor entre el 2003 y el 2005, y, cinco años después, en formato impreso por Ediciones Tácitas (2010). En este ensayo analizaré detenidamente los vínculos y tensiones materiales entre la versión en pantalla y la versión en papel. Propongo que sus diferencias dan cuenta de una exhaustiva experimentación y reflexión a nivel formal, y que, por lo tanto, no se trata de un simple traspaso de soportes. Como se verá, la importancia de la dimensión material constituye un aspecto fundamental de la poética del libro.
DOI: https://doi.org/10.14195/2182-8830_7-1_7
Recensão: LITERATURA E CIÊNCIA NA FICÇÃO DO SÉCULO XIX — MARIA HELENA SANTANA
Authors: Soler Elena Losada 
Published: May 2020

Recensão crítica de MARIA HELENA SANTANA. LITERATURA E CIÊNCIA NA FICÇÃO DO SÉCULO XIX. Lisboa, Imprensa Nacional-Casa da Moeda, 2007. 576 páginas. ISBN: 9789722714624.
Recensão: ANTERO DE QUENTAL E A VIAGEM À AMÉRICA — ANA MARIA ALMEIDA MARTINS
Authors: Santana Maria Helena 
Published: May 2020

Recensão crítica de ANA MARIA ALMEIDA MARTINS. ANTERO DE QUENTAL E A VIAGEM À AMÉRICA. REMANDO CONTRA A MARÉ. Lisboa, Tinta da China, 2011. 160 páginas. ISBN: 9789896710545.
Recensão: [DES]CONEXÕES ENTRE PORTUGAL E O BRASIL SÉCULOS XIX E XX - TANIA MARTUSCELLI
Authors: Mello Cristina 
Published: May 2020

Recensão crítica de [DES]CONEXÕES ENTRE PORTUGAL E O BRASIL SÉCULOS XIX E XX, TANIA MARTUSCELLI. Lisboa, Colibri, 2016. 208 páginas, ISBN 978-989-689-605-8
J. Ignacio Díez, Ficciones y confesiones: Francisco Umbral (y otros escritores contemporáneos). Madrid, Dalya, 2019
Authors: Ferri Coll José María 
Published: May 2020

Reseña de: J. Ignacio Díez, Ficciones y confesiones: Francisco Umbral (y otros escritores contemporáneos). Madrid, Dalya, 2019, ISBN:9788494695032, 272 pp.
A kulturális különbségeken túl
Authors: Géczy Dorottya , Varga Zsófia 
Published: May 2020

Hogy hogyan gondolkodunk a nemünkről, az mélyen gyökerezik a társadalmi, ideológiai kontextrusba, amiben élünk. A különböző szerepeink, identitás tartalmaink társadalmi folyamatok, és a társadalom tagjai által kommunikáció révén létrejövő konszenzusok eredményei. A társadalom szélesebb ideológiai kontextusa nemcsak a nemek tartalmát befolyásolja, hanem lehetséges dinamikájukat isKutatásunkban arra voltunk kíváncsiak, hogy a nem konstrukciója milyen viszonyban állhat a különböző identitás állapotokkal és a fenyegetettségekkel a roma és nem-roma társadalomban ma Magyarországon. Azt is megvizsgáltuk, hogy a nem reprezentációja és az identitás fenyegetettség milyen kapcsolatban áll a szocioökonómiai-státusszal, az iskolai végzettséggel, a lakóhely típusával, a bevétellel, a szubjektív jólléttel és a foglalkozással. Illetve, hogy mik azok a konstrukcuók, amik a nemi identitásra fenyegetően hatnak. Összehasonlító vizsgálatot végeztünk 288 résztvevővel vegyes módszeres kérdőív alkalmazásával. A nem reprezentácóinak feltárásához asszociációs módszert használtunk, az identitás fenyegetetstég és távolításhoz pedig az MTPQ (Multiple Threat and Prejudice Questionnaire) kérdőívet alkalmaztuk. Eredményeink alapján elmondhatjuk, hogy különbségeket találtunk a nemi reprezentációkban a kisebbség és a többség tagjai között. Úgy tűnik, a roma válaszadók nem-reprezentációja konzervítvabb, míg a nem-roma válaszadóké jóval diverzebb. Ez köszönhető az iskolázottság vagy egyéb szocio-ökonomia státuszban való különbségnek a két csoport között, ahol általában a romák szenvednek el hátrányt. A nemi identitás fenyegetettsége viszont nem kapcsolódik az etnikai hovatartozáshoz, a kultúrához. Azt találtuk, az embereket általában fenyegetik a társadalmi elvárások, a kollektív vagy szociális reprezentációk a saját nemükre vonatkozóan. Végső következtetésként eredményeink alapján azt monthatjuk, a sztereotipikus nem-értlemezésre számos demográfiai tényező hat, mint az iskolázottság, lakóhely, munka, kereset, ám a nemi identitás fenyegetettség, csakúgy, mint más identitás fenyegetettségek, inkább egy többség által megkonstruált identitás tartalomra és értékre reflektál.
An atypical presentation of ataxia telangiectasia in a school-aged boy secondary to an intronic mutation
Authors: Scott Ori , Dinur-Schejter Yael , Upton Julia , Feanny Stephen 
Published: May 2020

Background: Ataxia telangiectasia typically presents in early pre-school years with progressive cerebellar ataxia and oculocutaneous telangiectasias. Referral to Immunology is often made after diagnosis has been established, as patients are prone to both humoral and cellular immune abnormalities. Case presentation: We herein report a 10-year old boy, previously undiagnosed, who presented with recurrent pneumonias. On history, frequent falls and speech difficulty were reported, with no telangiectasias on exam. Screening with alpha-fetoprotein was abnormal, followed by ATM gene sequencing, showing a homozygous intronic mutation. Over the next 3 years the patient deteriorated neurologically, and developed appreciable telangiectasias. Conclusion: A review of the literature demonstrates that intronic/splicing mutations may result in atypical ataxia telangiectasia phenotypes and delayed presentations. We advise immunologists to have a high index of suspicion for ataxia telangiectasia when assessing a patient with immunodeficiency and neurologic regression, regardless of age, and even in the absence of telangiectasias. Statement of novelty: We present a case of phenotypically atypical (“leaky”) ataxia telangiectasia resulting from a novel homozygous splice-site mutation in the ATM gene. Given high reported prevalence of intronic and splice-site mutations in ATM, we recommend full gene sequencing in patients suspected to have ataxia telangiectasia, especially in those with late onset or unusual manifestations.
Absence of recovery in a degraded eelgrass (Zostera Marina) bed in Nova Scotia, Canada: Results from a transplant study
Authors: Wilson Erin , Garbary David J. 
Published: May 2020

By the early 2000s, the invasion of the European green crab (Carcinus maenas) had caused a severe decline of eelgrass (Zostera marina) beds in eastern Canada. The formerly lush eelgrass bed in Benoit Cove, Nova Scotia, was extirpated by 2009 and has subsequently failed to recover. The objective of our study was to establish if Benoit Cove (BC) has reached a new equilibrium in which eelgrass cannot recolonize. From July 3 - August 29, 2018, we transplanted eelgrass using frames and monitored eelgrass growth and survival relative to the nearby donor (control) site in Tracadie West Arm (TWA) that had an extensive eelgrass meadow with over 95% cover. Transplant survival was 91.6% and 15.4% for TWA and BC, respectively (P < 0.001). Above-ground growth declined at both sites, and could be associated with high summer water temperatures and/or extreme epiphytism. Sediments at both sites had high silt composition (> 28%), and the absence of a macrophyte canopy lead to increased light attenuation in BC in moderate wind and tidal currents. The low density of green crabs in both BC and TWA (0.01 m-2 and 0.08 m-2, respectively), and the apparently healthy eelgrass bed in TWA, suggest that green crabs are not having a negative effect on eelgrass in this system and are not responsible for the lack of recolonization of eelgrass in BC.Keywords: Atlantic Canada; eelgrass bed; European green crab; transplant; Zostera marina
Evaluating out-planting success and mycorrhizal status of endangered Geum peckii Pursh (Rosaceae), the Eastern Mountain Avens, in Nova Scotia
Authors: Fancy Sarah , López-Gutiérrez Juan C. , Walker Allison K. , LaRue Diane , Browne Robin 
Published: May 2020

Geum peckii (Rosaceae), the Eastern Mountain Avens, is a small herbaceous plant that is listed as endangered federally and provincially. In Canada, this species is found in bogs on Brier Island and Harris Lake, Digby County, Nova Scotia. The only other population outside of Canada is in New Hampshire (USA). To enhance conservation research of this species, a seed sample from the native species seed bank at Acadia University was used to establish a plant tissue culture of G. peckii plants. Survival of out-planted material was then assessed in both the greenhouse and the field. The field test site was within 20km of the existing plant populations in Digby County. Our study also revealed that G. peckii grows in association with arbuscular mycorrhizal fungi (AMF). During out-planting, plants received a mycorrhizal inoculum with the goal of enhancing survival. We used either a commercial mycorrhizal inoculum, or a native inoculum. Control plants were left untreated. Survival was 97-100 % among all the treatments by the end of the 2016 planting season. The results to date underscore the potential value of seed banking for protection of endangered native plant species. This study marks the first time in Nova Scotia that an endangered plant species has been successfully retrieved from seed bank storage, propagated by tissue culture, and out-planted back into a natural habitat. Keywords: Conservation, endangered native species, Geum peckii, tissue culture propagation
Magical Realism as Historical Discourse Reflected on Eka Kurniawan's 'Beauty is A Wound'
Authors: Nurrahman Sadam , Rosyidi Mohamad Ikhwan 
Published: May 2020

This study aims to uncover magical realism as historical discourse portrayed in the novel Beauty is A Wound by Eka Kurniawan. Descriptive qualitative method used in this study. The data were collected by reading, classifying and interpreting. The result is the novel Beauty is A Wound has five elements of magical realism as Faris stated, they are; irreducible elements, phenomenal world, the unsettling doubt, merging realms and disruptions of time, space and identity. In relation with magical realism, New Historicism also applied to unearth Indonesia historical discourse since the time of late Dutch colonization, the invasion of Japan, the Independence Era and the New Order Era. Then, the massacre of everyone who were labeled as communist. And the genocide of all the thugs or preman in order to make safer and better society. In this novel, the history of Indonesia was camouflaged and mixed with magical realism because every event that categorized as magical realism led to the past events which related to the history of Indonesia.
Keywords: historical discourse, magical realism, new historicism
Strategies Used to Translate Idiomatic Expressions in 'A Walk to Remember' into Indonesian and The Resulted Equivalence
Authors: Angguntur Wayan , Hartono Rudi , Purwanto Bambang 
Published: May 2020

This study is conducted to analyze the translation strategies used to translate the idiomatic expressions in the novel “A Walk to Remember” into Indonesian, to analyze the degree of equivalence of the Indonesian translation, and to find out the relation between the strategy used and the degree of equivalence. The translation strategies used in this study are proposed by Baker while the degrees of equivalence are analyzed by using Bell’s theory. This research belongs to descriptive research using qualitative method to describe the objectives of this study. The data are analyzed by comparing the idioms in the English version to the Indonesian translation. After the data are identified, they are examined to find out the relation between the strategies used and the degree of equivalence. The findings of the analysis are: (1) four strategies were used to translate idioms in the novel A Walk to Remember into Indonesian, (2) in terms of degree of equivalence, it was found that most of the data were identified into fully equivalent translation, (3) in the relation between translation strategies used and the degree of equivalence, it was revealed that the translation strategies used mostly produce fully equivalent with complete meaning.
Keywords: a walk to remember, degree of meaning equivalance, idioms translation strategies