bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gouverneur’ syndrome in a young Hispanic patient: A case report of a rare presentation of a rectal adenocarcinoma tumor
Authors: Mejias Emanuel , Robles Yarret , Olivella Gerardo , Bolaños Guillermo 
Published: May 2020

Abstract
This is an unusual case report of 32-year-old Hispanic male who presented with an early-onset advanced stage colorectal cancer with an enterovesical fistula. A 32-year-old man presented to our institution referring suprapubic pain, urinary frequency, dysuria and tenesmus for several weeks suggesting Gouverneur’s syndrome. Patient had been treated with oral antibiotics for his recurrent urinary tract infections without resolution. Associated unintentional weight loss, decreased appetite and suprapubic pain raised concern for occult malignancy. Abdominopelvic computed tomography scan revealed a rectal mass with invasion to bladder. Colonoscopy biopsy confirmed diagnosis of moderately differentiated rectal adenocarcinoma. This report provides vital information about clinical presentations of enterovesical fistula in an imposed rectal adenocarcinoma in a young Hispanic adult with no previous family or medical history. A thorough clinical assessment must be taken to ensure accurate diagnosis and early detection of colorectal cancer in the young Hispanic population.
Variation in zinc concentration of sweetcorn kernels reflects source–sink dynamics influenced by kernel number
Authors: Cheah Zhong Xiang , O’Hare Tim J , Harper Stephen M , Bell Michael J 
Published: May 2020

AbstractGrain yield and mineral nutrient concentration in cereal crops are usually inversely correlated, undermining biofortification efforts. Here, sink size, expressed as kernel number per cob, was manipulated by controlling the time when the silks of sweetcorn (Zea mays) cv. Hybrix 5 and var. HiZeax 103146 were exposed to pollen. Twelve other varieties were manually pollinated to achieve the maximum potential kernel number per cob, and kernel Zn concentration was correlated with kernel number and kernel mass. As kernel number increased, kernel Zn concentration decreased, with the decrease occurring to similar extents in the embryo tissue and the rest of the kernel. However, total kernel Zn accumulated per cob increased with increasing kernel number, as the small decreases in individual kernel Zn concentration were more than offset by increases in kernel number. When both kernel number and mass were considered, 90% of the variation in kernel Zn concentration was accounted for. Differential distribution of assimilates and Zn to sweetcorn cobs led to significant decreases in kernel Zn concentration with increasing kernel number. This suggests there will be challenges to achieving high kernel Zn concentrations in modern high-yielding sweetcorn varieties unless genotypes with higher Zn translocation rates into kernels can be identified.
Urine S-Adenosylmethionine are Related to Degree of Renal Insufficiency in Patients with Chronic Kidney Disease
Authors: Kruglova Maria Petrovna , Ivanov Alexander Vladimirovich , Virus Edward Danielevich , Bulgakova Polina Olegovna , Samokhin Andrey Segeevich , Fedoseev Anatolij Nikolaevich , Grachev Sergej Vital’evich , Kubatiev Aslan Amirkhanovich 
Published: May 2020

Abstract

Objective
To determine whether urine S-adenosylmethionine (SAM) might be an indicator of chronic kidney disease (CKD).

Methods
We investigated urine levels of SAM and related metabolites (S-adenosylhomocysteine and homocysteine cysteine) in 62 patients (average age, 65.9 years) with CKD (stages II–V).

Results
Patients with stages III–V CKD stages have significantly decreased urine levels and SAM/S-adenosylhomocysteine ratio and also cysteine/homocysteine ratio in blood plasma (P &lt;.05), compared with patients with stage II CKD. Urine SAM levels allowed us to distinguish patients with mildly decreased kidney function from those with moderate to severe renal impairment (AUC, 0.791; sensitivity, 85%; specificity, 78.6%).

Conclusions
Our study results demonstrate that urine SAM is a potent biomarker for monitoring renal function decline at early CKD stages. Urine SAM testing confers an additional advantage to healthcare professionals in that it is noninvasive.
Systematic errors in strong gravitational lensing reconstructions, a numerical simulation perspective
Authors: Enzi Wolfgang , Vegetti Simona , Despali Giulia , Hsueh Jen-Wei , Benton Metcalf R 
Published: May 2020

ABSTRACT
We present the analysis of a sample of 24 SLACS-like galaxy–galaxy strong gravitational lens systems with a background source and deflectors from the Illustris-1 simulation. We study the degeneracy between the complex mass distribution of the lenses, substructures, the surface brightness distribution of the sources, and the time delays. Using a novel inference framework based on Approximate Bayesian Computation, we find that for all the considered lens systems, an elliptical and cored power-law mass density distribution provides a good fit to the data. However, the presence of cores in the simulated lenses affects most reconstructions in the form of a Source Position Transformation. The latter leads to a systematic underestimation of the source sizes by 50 per cent on average, and a fractional error in H0 of around $25_{-19}^{+37}$ per cent. The analysis of a control sample of 24 lens systems, for which we have perfect knowledge about the shape of the lensing potential, leads to a fractional error on H0 of $12_{-3}^{+6}$ per cent. We find no degeneracy between complexity in the lensing potential and the inferred amount of substructures. We recover an average total projected mass fraction in substructures of fsub &lt; 1.7–2.0 × 10−3 at the 68 per cent confidence level in agreement with zero and the fact that all substructures had been removed from the simulation. Our work highlights the need for higher resolution simulations to quantify the lensing effect of more realistic galactic potentials better, and that additional observational constraint may be required to break existing degeneracies.
Examining supernova events in Type 1 active galactic nuclei
Authors: Villarroel Beatriz , Imaz Iñigo , Lusso Elisabeta , Comerón Sébastien , Prieto M Almudena , Marziani Paola , Mattsson Lars 
Published: May 2020

ABSTRACT
A statistical study of intermediate Palomar Transient Factory supernovae (SNe) in Type 1 active galactic nuclei (AGNs) has shown a major deficit of supernovae around Type 1 AGN host galaxies, with respect to Type 2 AGN hosts. The aim of this work is to test whether there is any preference for Type 1 AGNs to host SN of a specific kind. Through the analysis of SN occurrence and their type (thermonuclear versus core-collapse), we can directly link the type of stars producing the SN events, thus this is an indirect way to study host galaxies in Type 1 AGNs. We examine the detection fractions of SNe, the host galaxies and compare the sample properties to typical host galaxies in the Open Supernova Catalog (OSC). The majority of the host galaxies in the AGN sample are late type, similar to typical galaxies hosting SN within the OSC. The findings are supportive of a deficiency of SNe near Type 1 AGNs, although we cannot with certainty assess the overall detection fractions of SNe in Type 1 AGNs relative to other SN host galaxies. We can state that Type 1 AGN has equal detection fractions of thermonuclear versus core-collapse SNe. However, we note the possibility of a higher detection rate of core-collapse supernovae in Type 1 AGN with insecure AGN classifications.
SHARP – VI. Evidence for CO (1–0) molecular gas extended on kpc-scales in AGN star-forming galaxies at high redshift
Authors: Spingola C , McKean J P , Vegetti S , Powell D , Auger M W , Koopmans L V E , Fassnacht C D , Lagattuta D J , Rizzo F , Stacey H R , Sweijen F 
Published: May 2020

ABSTRACT
We present a study of the stellar host galaxy, CO (1–0) molecular gas distribution and AGN emission on 50–500 pc-scales of the gravitationally lensed dust-obscured AGN MG J0751+2716 and JVAS B1938+666 at redshifts 3.200 and 2.059, respectively. By correcting for the lensing distortion using a grid-based lens modelling technique, we spatially locate the different emitting regions in the source plane for the first time. Both AGN host galaxies have 300–500 pc-scale size and surface brightness consistent with a bulge/pseudo-bulge, and 2 kpc-scale AGN radio jets that are embedded in extended molecular gas reservoirs that are 5–20 kpc in size. The CO (1–0) velocity fields show structures possibly associated with discs (elongated velocity gradients) and interacting objects (off-axis velocity components). There is evidence for a decrement in the CO (1–0) surface brightness at the location of the host galaxy, which may indicate radiative feedback from the AGN, or offset star formation. We find CO–H2 conversion factors of around αCO = 1.5 ± 0.5 (K km s−1 pc2)−1, molecular gas masses of &gt;3 × 1010 M⊙, dynamical masses of ∼1011 M⊙, and gas fractions of around 60 per cent. The intrinsic CO line luminosities are comparable to those of unobscured AGN and dusty star-forming galaxies at similar redshifts, but the infrared luminosities are lower, suggesting that the targets are less efficient at forming stars. Therefore, they may belong to the AGN feedback phase predicted by galaxy formation models, because they are not efficiently forming stars considering their large amount of molecular gas.
The VISTA Variables in the Vía Láctea infrared variability catalogue (VIVA-I)
Authors: Ferreira Lopes C E , Cross N J G , Catelan M , Minniti D , Hempel M , Lucas P W , Angeloni R , Jablonsky F , Braga V F , Leão I C , Herpich F R , Alonso-García J , Papageorgiou A , Pichara K , Saito R K , Bradley A J , Beamin J C , Cortés C , De Medeiros J R , Russell Christopher M P 
Published: May 2020

ABSTRACT
High extinction and crowding create a natural limitation for optical surveys towards the central regions of the Milky Way, where the gas and dust are mainly confined. Large-scale near-infrared (IR) surveys of the Galactic plane and bulge are a good opportunity to explore open scientific questions as well as to test our capability to explore future data sets efficiently. Thanks to the VISTA Variables in the Vía Láctea (VVV) ESO public survey, it is now possible to explore a large number of objects in those regions. This paper addresses the variability analysis of all VVV point sources having more than 10 observations in VVVDR4 using a novel approach. In total, the near-IR light curves of 288 378 769 sources were analysed using methods developed in the New Insight Into Time Series Analysis project. As a result, we present a complete sample having 44 998 752 variable star candidates (VVV-CVSC), which include accurate individual coordinates, near-IR magnitudes (Z,Y,J, and Hs), extinctions A(Ks), variability indices, periods, amplitudes, among other parameters to assess the science. Unfortunately, a side effect of having a highly complete sample, is also having a high level of contamination by non-variable (contamination ratio of non-variables to variables is slightly over 10:1). To deal with this, we also provide some flags and parameters that can be used by the community to decrease the number of variable candidates without heavily decreasing the completeness of the sample. In particular, we cross-identified 339 601 of our sources with Simbad and AAVSO data bases, which provide us with information for these objects at other wavelengths. This subsample constitutes a unique resource to study the corresponding near-IR variability of known sources as well as to assess the IR variability related with X-ray and gamma-ray sources. On the other hand, the other ${\sim }99.5{{\ \rm per\ cent}}$ sources in our sample constitutes a number of potentially new objects with variability information for the heavily crowded and reddened regions of the Galactic plane and bulge. The present results also provide an important queryable resource to perform variability analysis and to characterize ongoing and future surveys like TESS and LSST.
Which bright fast radio bursts repeat?
Authors: James C W , Osłowski S , Flynn C , Kumar P , Bannister K , Bhandari S , Farah W , Kerr M , Lorimer D R , Macquart J-P , Ng C , Phillips C , Price D C , Qiu H , Shannon R M , Spiewak R 
Published: May 2020

ABSTRACT
A handful of fast radio bursts (FRBs) are now known to repeat. However, the question remains – do they all? We report on an extensive observational campaign with the Australian Square Kilometre Array Pathfinder (ASKAP), Parkes, and Robert C. Byrd Green Bank Telescope, searching for repeat bursts from FRBs detected by the Commensal Real-time ASKAP Fast Transients survey. In 383.2 h of follow-up observations covering 27 FRBs initially detected as single bursts, only two repeat bursts from a single FRB, FRB 171019, were detected, which have been previously reported by Kumar et al. We use simulations of repeating FRBs that allow for clustering in burst arrival times to calculate new estimates for the repetition rate of FRB 171019, finding only slight evidence for incompatibility with the properties of FRB 121102. Our lack of repeat bursts from the remaining FRBs set limits on the model of all bursts being attributable to repeating FRBs. Assuming a reasonable range of repetition behaviour, at most 60 per cent (90 per cent confidence limit) of these FRBs have an intrinsic burst distribution similar to FRB 121102. This result is shown to be robust against different assumptions on the nature of repeating FRB behaviour, and indicates that if indeed all FRBs repeat, the majority must do so very rarely.
Application of the screened Coulomb potential to fit the DA-type variable star HS 0507 + 0434B
Authors: Chen Y H 
Published: May 2020

ABSTRACT
wdec is used to evolve grids of DA-variable (DAV) star models adopting the element diffusion scheme with pure and screened Coulomb potentials. The core compositions are thermonuclear burning results derived from mesa. mesa yields composition profiles that the version of wdec used in this work could not accommodate (most notably, the presence of helium in the core of the model). According to the theory of rotational splitting, Fu and colleagues identified six triplets for the DAV star HS 0507 + 0434B based on 206 h of photometric data. The grids of DAV star models are used to fit the six reliable m = 0 modes. When adopting the screened Coulomb potential, a best-fitting model of log(MHe/M*) = −3.0, log(MH/M*) = −6.1, Teff = 11 790 K, M* = 0.625 M⊙, log g = 8.066 and σRMS = 2.08 s was obtained. Compared with adopting the pure Coulomb potential, the value of σRMS is improved by 34 per cent. This study may provide a new method for research into mode-trapping properties.
Formation of massive globular clusters with dark matter and its implication on dark matter annihilation
Authors: Wirth Henriette , Bekki Kenji , Hayashi Kohei 
Published: May 2020

ABSTRACT
Recent observational studies of γ-ray emission from massive globular clusters (GCs) have revealed possible evidence of dark matter (DM) annihilation within GCs. It is, however, still controversial whether the emission comes from DM or from millisecond pulsars. We here present the new results of numerical simulations, which demonstrate that GCs with DM can originate from nucleated dwarfs orbiting the ancient Milky Way. The simulated stripped nuclei (i.e. GCs) have the central DM densities ranging from 0.1 to several M⊙ pc−3, depending on the orbits and the masses of the host dwarf galaxies. However, GCs born outside the central regions of their hosts can have no/little DM after their hosts are destroyed and the GCs become the Galactic halo GCs. These results suggest that only GCs originating from stellar nuclei of dwarfs can possibly have DM. We further calculate the expected γ-ray emission from these simulated GCs and compare them to observations of ω Cen. Given the large range of DM densities in the simulated GCs, we suggest that the recent possible detection of DM annihilation from GCs should be more carefully interpreted.
Mandated Representation: Exploring the Consequences of Gender Quota Design on Parliamentary Activity
Authors: Euchner Eva-Maria , Frech Elena 
Published: May 2020

Abstract
Although the scholarship on legislative behaviour widely agrees that electoral rules determine parliamentary activities, surprisingly little is known on the impact of gender quotas. We contribute to this research gap by developing an innovative interdisciplinary framework and by exploring it based on a unique dataset on varying gender quota designs throughout EU countries and parties running for the 7th term of the European Parliament (2009–2014). Based on the scholarship on gender diversity in management teams and the research on gendered processes in political parties, we argue that especially mandated gender quotas stimulate processes of social categorisation, intergroup biasing and competition due to a normative mis-fit between conceptions of gender equality and gender quotas, which in turn influences coordination and communication and hence, parliamentary activity more generally. Combining negative-binomial regression models and expert interviews, we indeed find that mandated gender quotas promote ‘individual’ parliamentary activities (e.g. speeches) and tend to impede ‘collaborative’ parliamentary activities (e.g. reports).
Early Detection of In-Patient Deterioration: One Prediction Model Does Not Fit All
Authors: Blackwell Jacob N. , Keim-Malpass Jessica , Clark Matthew T. , Kowalski Rebecca L. , Najjar Salim N. , Bourque Jamieson M. , Lake Douglas E. , Moorman J. Randall 
Published: May 2020

Objectives:
Early detection of subacute potentially catastrophic illnesses using available data is a clinical imperative, and scores that report risk of imminent events in real time abound. Patients deteriorate for a variety of reasons, and it is unlikely that a single predictor such as an abnormal National Early Warning Score will detect all of them equally well. The objective of this study was to test the idea that the diversity of reasons for clinical deterioration leading to ICU transfer mandates multiple targeted predictive models.

Design:
Individual chart review to determine the clinical reason for ICU transfer; determination of relative risks of individual vital signs, laboratory tests and cardiorespiratory monitoring measures for prediction of each clinical reason for ICU transfer; and logistic regression modeling for the outcome of ICU transfer for a specific clinical reason.

Setting:
Cardiac medical-surgical ward; tertiary care academic hospital.

Patients:
Eight-thousand one-hundred eleven adult patients, 457 of whom were transferred to an ICU for clinical deterioration.

Interventions:
None.

Measurements and Main Results:
We calculated the contributing relative risks of individual vital signs, laboratory tests and cardiorespiratory monitoring measures for prediction of each clinical reason for ICU transfer, and used logistic regression modeling to calculate receiver operating characteristic areas and relative risks for the outcome of ICU transfer for a specific clinical reason. The reasons for clinical deterioration leading to ICU transfer were varied, as were their predictors. For example, the three most common reasons—respiratory instability, infection and suspected sepsis, and heart failure requiring escalated therapy—had distinct signatures of illness. Statistical models trained to target-specific reasons for ICU transfer performed better than one model targeting combined events.

Conclusions:
A single predictive model for clinical deterioration does not perform as well as having multiple models trained for the individual specific clinical events leading to ICU transfer.
Making People Whole Through the Breath of Life
Authors: Seunarine Elizabeth 
Published: May 2020

ABSTRACT:
For 50 years, Medical Ministry International has provided healthcare relief and development in 30 countries. Interprofessional teams of local and visiting volunteer workers promote healthcare sustainability, which has become more attainable with the addition of integrated health education based on Jesus' model of wholeness. Instructors teach basic health concepts to community residents while relating truths about God and his Word. Long-term change is evident when teams return to previously visited sites.
Pulmonary function decline in immediate postoperative period is not necessarily related to residual neuromuscular block
Authors: Thudium Marcus , Kornilov Evgeniya , Raczeck Lukas , Boehm Olaf 
Published: May 2020

BACKGROUND
Previous studies have reported an association between the use of neuromuscular blocking (NMB) agents and postoperative pulmonary complications. Postoperative pulmonary function is a key indicator for postoperative pulmonary complications. Several sites can be used to assess depth and recovery from NMB.

OBJECTIVES
To investigate postoperative pulmonary function change in relation to train-of-four measurements at the adductor pollicis and corrugator supercilii muscles, and anaesthesia-related variables in orthopaedic patients undergoing hip or knee arthroplasty.

DESIGN
Observational study.

SETTING
University hospital.

PATIENTS
Orthopaedic patients undergoing hip or knee arthroplasty.

MAIN OUTCOME MEASURES
Postoperative pulmonary function tests in the postanaesthesia care unit.

METHODS
Patients scheduled for elective hip or knee arthroplasty received simultaneous corrugator supercilii and adductor pollicis measurements during anaesthesia conducted according to clinical standards. Forced expiratory volume in 1 s and forced vital capacity (FVC) were measured at the time of inclusion and postoperatively on the postanaesthesia care unit. Linear regression analysis was performed for association between risk factors and pulmonary function change.

RESULTS
A total of 35 patients were included. After exclusions, 20 patients remained for final analysis. Corrugator supercilii showed earlier NMB recovery than adductor pollicis. FVC decreased significantly after surgery from 2.9 ± 1.0 to 2.3 ± 1.0 (P < 0.01) and forced expiratory volume in 1 s decreased from 2.3 ± 0.9 to 1.6 ± 0.8 l (P < 0.01). Patient age was the only factor significantly related to FVC decrease after surgery (P = 0.019) with a cut-off value of 65 years.

CONCLUSION
Both corrugator supercilii and adductor pollicis failed to indicate recovery of pulmonary function after NMB. Age seems to be a risk factor for postoperative decline in pulmonary function.

TRIAL REGISTRATION
German Clinical Trials registry, DRKS-ID: DRKS00014305.
Optimizing outcomes for keratoplasty in ectatic corneal disease
Authors: Yu Angeli Christy , Mattioli Leila , Busin Massimo 
Published: May 2020

Purpose of review
Advanced keratectasia often requires corneal transplantation for restoration of vision. This review discusses the surgical approach suitable for these cases including significant updates in the current literature.

Recent findings
With greater understanding of ectatic corneal disease and its associated operative challenges, several modifications in the surgical approach have been developed. Identified predictive factors for successful pneumatic dissection and intraoperative complications have informed surgical planning and decision-making. In the setting of failed pneumatic dissection, sequential use of alternative lamellar dissection techniques is a reasonable surgical strategy. Surgical refinements to optimize visual outcomes and postoperative interventions to correct residual refractive errors have improved visual rehabilitation after keratoplasty.

Summary
With evidence of its undisputed advantages, DALK has been widely recognized as the primary surgical option for ectatic corneal disease.