bluuebunny/crossref_metadata_2025_split huggingface dataset:
Findings of a feasibility study of pre-operative pulmonary rehabilitation to reduce post-operative pulmonary complications in people with chronic obstructive pulmonary disease scheduled for major abdominal surgery
Authors: Marlow Lucy L. , Lee Angeline H.Y. , Hedley Emma , Grocott Michael P. , Steiner Michael C. , Young J. Duncan , Rahman Najib M. , Snowden Christopher P. , Pattinson Kyle T.S. 
Published: March 2020

Background: Patients with chronic obstructive pulmonary disease (COPD) are at increased risk of complications and death following surgery. Pulmonary complications are particularly prominent. Pulmonary rehabilitation is a course of physical exercise and education that helps people with COPD manage their condition. Although proven to improve health outcomes in patients with stable COPD, it has never been formally tested as a pre-surgical intervention in patients scheduled for non-cardiothoracic surgery. If a beneficial effect were to be demonstrated, pulmonary rehabilitation for pre-surgical patients with COPD might be rapidly implemented across the National Health Service, as pulmonary rehabilitation courses are already well established across much of the United Kingdom (UK). Methods: We performed a feasibility study to test study procedures and barriers to identification and recruitment to a randomised controlled trial testing whether pulmonary rehabilitation, delivered before major abdominal surgery in a population of people with COPD, would reduce the incidence of post-operative pulmonary complications. This study was run in two UK centres (Oxford and Newcastle upon Tyne). Results: We determined that a full randomised controlled trial would not be feasible, due to failure to identify and recruit participants. We identified an unmet need to identify more effectively patients with COPD earlier in the surgical pathway. Service evaluations suggested that barriers to identification and recruitment would likely be the same across other UK hospitals. Conclusions: Although pulmonary rehabilitation is a potentially beneficial intervention to prevent post-operative pulmonary complications, a randomised controlled trial is unlikely to recruit sufficient participants to answer our study question conclusively at the present time, when spirometry is not automatically conducted in all patients planned for surgery. As pulmonary rehabilitation is a recommended treatment for all people with COPD, alternative study methods combined with earlier identification of candidate patients in the surgical pathway should be considered. Trial registration: ISRCTN29696295, 31/08/2017
Genomic and protein structure modelling analysis depicts the origin and pathogenicity of 2019-nCoV, a new coronavirus which caused a pneumonia outbreak in Wuhan, China
Authors: Dong Ning , Yang Xuemei , Ye Lianwei , Chen Kaichao , Chan Edward Wai-Chi , Chen Sheng 
Published: March 2020

Background: A pandemic outbreak caused by a novel coronavirus, 2019-nCoV, has originated from Wuhan, China and spread to many countries around the world. The outbreak has led to around 45 thousand cases and over one thousand death so far. Methods: Phylogenetic analysis and sequence alignment were used to align the whole genome sequence of 2019-nCoV with other over 200 sequences of coronaviruses to predict the origin of this novel virus. In addition, protein modeling and analysis were performed to access the potential binding of the spike protein of 2019-nCoV with human cell receptor, angiotensin-converting enzyme 2 (ACE2). Results: Detailed genomic and structure-based analysis of a new coronavirus, namely 2019-nCoV, showed that the new virus is a new type of bat coronavirus and is genetically fairly distant from the human SARS coronavirus. Structure analysis of the spike (S) protein of this new virus showed that its S protein only binds much weaker to the ACE2 receptor on human cells whereas the human SARS coronavirus exhibits strongly affinity to the ACE receptor. Conclusions: These findings suggest that the new virus should theoretically not be able to cause very serious human infection when compared to human SARS virus. However, the lower pathogenicity of this new virus may lead to longer incubation time and better adaption to human, which may favor its efficient transmission in human. These data are important to guide design of infection control policy and inform the public on the nature of threat imposed by 2019-nCov. Most importantly, using the analysis platform that we have developed, we should be able to predict whether the new mutations could lead to the increase of infectivity of the mutated virus in a very short time.
A new approach to managing follow-up patients with sino-nasal disorders: the rhinology panel
Authors: Abushaala Abdulaziz , Sargent Helen , McLean Jennifer , Grech-Marguerat Deborah , Khalil Hisham 
Published: March 2020

Background/aims There is a growing backlog of patients with sino-nasal disorders waiting for a follow-up appointment. This study aimed to identify rhinology patients on the outpatient follow-up list who could be removed from the waiting list for a face to face follow-up appointment and instead either given a phone consultation by a clinical nurse specialist or discharged from the service. Methods The clinical records of patients on the waiting list for a follow-up appointment at a nasal disorders clinic were reviewed by a panel comprising a consultant rhinologist, a rhinology fellow, a specialist registrar and two nurse specialists. Results A total of 300 clinical records of patients on the follow-up list of the Rhinology clinic were identified, of which 253 were found to have a sino-nasal disorder. Of these, 137 patients (54%) were discharged from the rhinology face to face follow-up clinics, while 116 patients (46%) were given face to face review appointments. Conclusions A multi-professional rhinology review panel is an effective way of managing the waiting list of an outpatient rhinology clinic and providing nurse-led telephone consultations could decrease the strain on resources while maintaining patient safety.
From handover to takeover: should we consider a new conceptual model of communication?
Authors: Spranzi Francesca , Norton Christine 
Published: March 2020

Objective This service evaluation aimed to collect data on clinical handover on labour ward and compare them with the local guideline. Design and methods This service evaluation was structured in four stages, each using a different design and research methods. Setting The study was undertaken between September 2013 and August 2014 in a maternity unit in a large NHS teaching hospital in London, UK. Findings and conclusion Communication breakdown is widely considered to be a significant factor contributing to poor patient outcomes, with handover being a major risk point. The discrepancy between the local guideline and current clinical practice reinforces the belief that urgent action is needed to improve clinical handover on labour ward. The results of this service evaluation suggest that a drastic overhaul of the communication model during handover should be considered, ie from handover to takeover, and that the mnemonic SBAR may not be fit-for-purpose in maternity care and should be replaced with a different format that reflects the chronological flow of clinical events.
Simple and fully CMOS-compatible low-loss fiber coupling structure for a silicon photonics platform
Authors: Maegami Yuriko , Okano Makoto , Cong Guangwei , Suzuki Keijiro , Ohno Morifumi , Narushima Toshihiro , Yokoyama Nobuyuki , Seki Miyoshi , Ohtsuka Minoru , Namiki Shu , Yamada Koji 
Published: March 2020

A simple low-loss fiber coupling structure consisting of a Si
inverted-taper waveguide and a 435 nm wide and 290 nm thick SiN
waveguide was fabricated with fully complementary metal-oxide
semiconductor (CMOS)-compatible processes. The small SiN waveguide can
expand to the optical field corresponding to a fiber with a mode-field
diameter of 4.1 µm. The fiber-to-chip coupling losses were 0.25 and
0.51 dB/facet for quasi-TE and quasi-TM modes, respectively, at a
1550 nm wavelength. Polarization-dependent losses of the conversion in
the Si-to-SiN waveguide transition and the fiber-to-chip coupling were
less than 0.3 and 0.5 dB, respectively, in the wavelength range of
1520–1580 nm.
Phosphorus-free 1.5  µm InAs quantum-dot microdisk lasers on metamorphic InGaAs/SOI platform
Authors: Wei Wen-Qi , Zhang Jie-Yin , Wang Jian-Huan , Cong Hui , Guo Jing-Jing , Wang Zi-Hao , Xu Hong-Xing , Wang Ting , Zhang Jian-Jun 
Published: March 2020

III–V semiconductor lasers epitaxially grown on silicon, especially on a silicon-on-insulator (SOI) platform, have been considered one of the most promising approaches to realize an integrated light source for silicon photonics. Although notable achievements have been reported on InP-based 1.5 µm III–V semiconductor lasers directly grown on silicon substrates, phosphorus-free 1.5 µm InAs quantum dot (QD) lasers on both silicon and SOI platforms are still uncharted territory. In this work, we demonstrate, to the best of our knowledge, the first phosphorus-free InAs QD microdisk laser epitaxially grown on SOI substrate emitting at the telecommunications S-band by growing metamorphic InAs/InGaAs QDs on (111)-faceted SOI hollow structures. The lasing threshold power for a seven-layer InAs QD microdisk laser with a diameter of 4 µm is measured as 234 μW at 200 K. For comparison, identical microdisk lasers grown on GaAs substrate are also characterized. The results obtained pave the way for an on-chip 1.5 µm light source for long-haul telecommunications.
Zero-order-free meta-holograms in a broadband visible range
Authors: Fu Rao , Deng Liangui , Guan Zhiqiang , Chang Sheng , Tao Jin , Li Zile , Zheng Guoxing 
Published: March 2020

The unwanted zero-order light accompanied by the birth of diffractive optical elements and caused mainly by fabrication errors and wavelength variations is a key factor that deteriorates the performance of diffraction-related optical devices such as holograms, gratings, beam shapers, beam splitters, optical diffusers, and diffractive microlenses. Here, inspired by the unique characteristic of nano-polarizer-based metasurfaces for both positive and negative amplitude modulation of incident light, we propose a general design paradigm to eliminate zero-order diffraction without burdening the metasurface design and fabrication. The experimentally demonstrated meta-hologram, which projects a holographic image with a wide angle of

70
°
×
70
°

in the far field, presents a very low zero-order intensity (only 0.7% of the total energy of the reconstructed image). More importantly, the zero-order-free meta-hologram has a large tolerance limit for wavelength variations (under a broadband illumination from 520 to 660 nm), which brings important technical advances. The strategy proposed could significantly relieve the fabrication difficulty of metasurfaces and be viable for various diffractive-optics-related applications including holography, laser beam shaping, optical data storage, vortex beam generation, and so on.
Noncoding Microdeletion in MouseHgfDisrupts Neural Crest Migration into the Stria Vascularis, Reduces the Endocochlear Potential, and Suggests the Neuropathology for Human Nonsyndromic Deafness DFNB39
Authors: Morell Robert J. , Olszewski Rafal , Tona Risa , Leitess Samuel , Wafa Talah T. , Taukulis Ian , Schultz Julie M. , Thomason Elizabeth J. , Richards Keri , Whitley Brittany N. , Hill Connor , Saunders Thomas , Starost Matthew F. , Fitzgerald Tracy , Wilson Elizabeth , Ohyama Takahiro , Friedman Thomas B. , Hoa Michael 
Published: March 2020

Hepatocyte growth factor (HGF) is a multifunctional protein that signals through the MET receptor. HGF stimulates cell proliferation, cell dispersion, neuronal survival, and wound healing. In the inner ear, levels of HGF must be fine-tuned for normal hearing. In mice, a deficiency of HGF expression limited to the auditory system, or an overexpression of HGF, causes neurosensory deafness. In humans, noncoding variants inHGFare associated with nonsyndromic deafnessDFNB39. However, the mechanism by which these noncoding variants causes deafness was unknown. Here, we reveal the cause of this deafness using a mouse model engineered with a noncoding intronic 10 bp deletion (del10) inHgf. Male and female mice homozygous for del10 exhibit moderate-to-profound hearing loss at 4 weeks of age as measured by tone burst auditory brainstem responses. The wild type (WT) 80 mV endocochlear potential was significantly reduced in homozygous del10 mice compared with WT littermates. In normal cochlea, endocochlear potentials are dependent on ion homeostasis mediated by the stria vascularis (SV). Previous studies showed that developmental incorporation of neural crest cells into the SV depends on signaling from HGF/MET. We show by immunohistochemistry that, in del10 homozygotes, neural crest cells fail to infiltrate the developing SV intermediate layer. Phenotyping and RNAseq analyses reveal no other significant abnormalities in other tissues. We conclude that, in the inner ear, the noncoding del10 mutation inHgfleads to developmental defects of the SV and consequently dysfunctional ion homeostasis and a reduction in the EP, recapitulating human DFNB39 nonsyndromic deafness.SIGNIFICANCE STATEMENTHereditary deafness is a common, clinically and genetically heterogeneous neurosensory disorder. Previously, we reported that human deafness DFNB39 is associated with noncoding variants in the 3′UTR of a short isoform ofHGFencoding hepatocyte growth factor. For normal hearing, HGF levels must be fine-tuned as an excess or deficiency of HGF cause deafness in mouse. Using aHgfmutant mouse with a small 10 bp deletion recapitulating a humanDFNB39noncoding variant, we demonstrate that neural crest cells fail to migrate into the stria vascularis intermediate layer, resulting in a significantly reduced endocochlear potential, the driving force for sound transduction by inner ear hair cells. HGF-associated deafness is a neurocristopathy but, unlike many other neurocristopathies, it is not syndromic.
Studi Living Al-Qur’an Pada Praktek Quranic Healing Kota Bengkulu (Analisis Deskriptif Terhadap Penggunaan Ayat-ayat Al-Qur’an)
Authors: Farhan Ahmad 
Published: March 2020

Al-Qur’an adalah representasi dari penjelmaan pesan-pesan universal Tuhan kepada hamba, hadir dalam bentuk teks verbal yang teraplikasikan dengan simbol-simbol bunyi yang mewakili firman Allah swt kepada Nabi Muhammad saw dengan menggunakan bahasa Arab. Sebagai wahyu dan petunjuk hidup bagi manusia, setiap muslim harus membaca, mehamami isinya serta mengaplikasikannya dalam kehidupan. Pembacaan yang dilakukan tentunya akan melahirkan pemahaman yang setiap muslim satu sama lainnya cenderung tidak sama. Hal ini menjadi niscaya karena terkait perbedaan kemampuan dan intensitas dalam membacanya. Dari pemahaman yang berbeda tadi, masing-masing juga akan melahirkan perilaku yang beragam pula Studi Living Al-Qur’an pada Praktek Quranic Healing Kota Bengkulu (Analisis Deskriptif terhadap Penggunaan Ayat-ayat Al-Qur’an) sebagai bentuk tafsir al-Qur’an dalam praksis kehidupan, baik pada wilayah teologis filosofis, psikologis maupun kultural.
Amenorrea primaria
Authors: Sepúlveda-Agudelo Janer , Alarcón-Nivia Miguel Ángel , Jaimes-Carvajal Hermes 
Published: March 2020

Objetivo: se hace una revisión detallada de la amenorreaprimaria, teniendo como base la clasificación propuesta por Mashchak CA y col. de acuerdo con la presencia o ausencia del desarrollo mamario y la presencia o no de útero, por ser la de mayor utilidad para el enfoque de manejo de las pacientes con amenorrea primaria.Metodología: se realizó una búsqueda de la literatura publicada en inglés a través de MEDLINE y OVID, usando como palabras clave: amenorrhea, primary amenorrhea, menstrual disorders, Turner syndrome, Kallmann syndrome, Prader-Willi síndrome, hypogonadotropic-hypogonadism; y se clasificó la información como soporte de la presente revisión, realizando resúmenes para su análisis.Resultados: la amenorrea primaria puede ser causada por una variedad de alteraciones que incluyen anormalidades müllerianas, gonadales, hipofisiarias, hipotalámicas, adrenales y tiroideas, o disfunciones hormonales en estos diferentes niveles. Estas anormalidades pueden ser congénitas por defectos cromosómicos o genéticos, o adquiridas, por lo tanto, es importante realizar un diagnóstico certero de esta patología para llevar a cabo un enfoque terapéutico adecuado, con el fin de disminuir todas las consecuencias que la enfermedad puede causar. Conclusiones: el tratamiento de las pacientes con amenorrea primaria debe ser individualizado, de acuerdo con las posibilidades terapéuticas de cada paciente, pero existen unas preguntas generales que tienen todas las pacientes o sus familiares y son relacionadas con la menstruación y los ciclos menstruales espontáneos posteriores, fertilidad, sexualidad y posibilidad de coitos con penetración vaginal satisfactoria.
Manejo laparoscópico de quiste gigante de ovario: reporte de caso
Authors: Zapata-Pérez Federico , Castañeda-Roldán Juan David , De los Ríos-Posada José Fernando , Arango-Martínez Adriana María , Mesa-Cock Ricardo Anibal 
Published: March 2020

Objetivo: revisar las consideraciones técnicas, indicaciones, riesgos y beneficios de este tipo de abordaje en masas pélvicas gigantes. Se presenta un caso en el que se realizó el abordaje laparoscópico de una masa quística ovárica de gran tamaño y su extracción a través de colpotomía posterior. La cirugía laparoscópica de los quistes gigantes de ovario surge como una alternativa a considerar en el manejo de estas pacientes.
Tumor adenomatoide del tracto genital femenino. Informe de dos casos de cuerpo uterino y ovario, y revisión de la literatura
Authors: Fajardo-Bernal Luisa M. , Acosta-Forero Jinneth , Ricaurte-Guerrero Orlando 
Published: March 2020

Objetivo: informar dos casos de tumor adenomatoide (TA) del tracto genital femenino y efectuar una revisión de la literatura, con énfasis en sus aspectos histopatológicos y diagnóstico diferencial.Presentación de los casos: se informan dos casos de TA del tracto genital femenino, diagnosticados mediante estudios histológicos y de inmunohistoquímica de piezas quirúrgicas. El primero corresponde a una paciente de 39 años que consultó por hemorragia uterina, a quien se le realizó diagnóstico clínico y ecográfico de miomatosis uterina, para el cual se le practicó histerectomía y cuyo estudio patológico demostró un tumor adenomatoide del cuerpo uterino. El segundo caso se presentó en una paciente de 26 años con masa de ovario izquierdo, cuyo material histológico fue remitido para consulta con diagnóstico inicial de tumor de seno endodérmico.Discusión: el TA es un tumor benigno de origen mesotelial, infrecuente en el tracto genital femenino, cuyo tratamiento sólo requiere cirugía conservadora. Su diagnóstico diferencial incluye tumores malignos primarios y metastáticos, tanto del cuerpo uterino como del ovario, que de acuerdo con su estado clínico, requieren para su manejo cirugía oncológica y quimioterapia y/o radioterapia complementarias.
AVALIAÇÃO DA DECOMPOSIÇÃO TÉRMICA DE ESPÉCIES DE BAMBU POR TERMOGRAVIMETRIA
Authors: Campos Rafaela Faber de , Weirich Neto Pedro Henrique , Antunes Sandra Regina Masetto , Arrúa Maria Elena Payret 
Published: March 2020

Rafaela Faber de Campos[1]Pedro Henrique Weirich Neto[2]Sandra Regina Masetto Antunes3Maria Elena Payret Arrúa4 RESUMOA biomassa sempre foi uma das fontes de energia mais utilizadas pelo homem, e como consequência, principalmente, dos problemas enfrentados pelo uso de combustíveis fosseis assume, novamente, grande importância. Vários tipos de biomassa podem ser citados, como por exemplo, a madeira de árvores, entretanto nem sempre é a mais adequada para geração de energia. O bambu entre outras plantas apresenta estrutura ímpar e, se destaca pela produtividade, podendo-se tornar uma alternativa sustentável para a geração de energia. Neste trabalho foi investigada a estabilidade térmica, consequentemente, a degradação térmica de quatro espécies de bambu in natura e na forma de carvão utilizando a termogravimetria (TGA). As espécies avaliadas foram Phyllostachys aurea A. C. Rivière (bambu dourado), Chusquea gracilis McClure & Smith (criciúma), Chusquea mimosa McClure & Smith (caratuva) e Merostachys multiramea Hackel (taquara lixa), presentes no centro-sul do estado do Paraná - Brasil. A análise dos resultados de termogravimetria indica que a decomposição destas espécies de bambu ocorre em 3 etapas. Estas etapas são associadas a perda de umidade (primeira), decomposição da hemicelulose e celulose (segunda) e decomposição da lignina (terceira). As espécies se diferenciam na temperatura de velocidade máxima de decomposição devido, provavelmente, às suas distintas composições.
ECONOMIC, ENVIRONMENTAL AND PRODUCTIVE PRACTICES INFLUENCE ON THE INDUSTRIAL ENERGETIC EFFICIENCY
Authors: Neves Fábio De Oliveira , Ewbank Henrique , Roveda José Arnaldo Frutuoso , Trianni Andrea , Marafão Fernando Pinhabel , Roveda Sandra Regina Monteiro Masalskiene 
Published: March 2020

The industrial energetic efficiency (EE) is recognized as one of the main factors for the reduction of gas emissions that cause the greenhouse effect and for the improvement of the industrial competiveness. Within this context, many papers of the international literature have proposed different indicators of industrial, economic and environmental behavior, so as to promote the EE inside the industries. However, such proposals do not generally check the result of the joint work for more than one indicator in the organizations, making more global analysis more difficult related to EE. This paper aims to check which environmental, economic and industrial practices indicators influence the EE of the industries. The data have been collected from the framework developed by Trianni et al. (2014), that analysed the main energetic efficiency measures for the technologies: motors, lighting, compressed air and HVAC systems (heating, ventilation and air conditioning). A logistic regression model has been adjusted for understand the relationship the economic, environmental and productive practices behavior on the energetic efficiency. Results suggest that a healthy workplace enables investments in equipment and machinery, allowing the EE inside the industries.
Suplement do badań nad polskimi modlitewnikami drukowanymi XVI wieku. Próba identyfikacji i chronologizacji arkusza ze zbiorów Archiwum Archidiecezjalnego w Gnieźnie na podstawie analizy zdobiących go drzeworytów
Authors: Krzak-Weiss Katarzyna 
Published: March 2020

SUPLEMENT DO BADAŃ NAD POLSKIMI MODLITEWNIKAMI DRUKOWANYMI XVI WIEKU. PRÓBA IDENTYFIKACJI I CHRONOLOGIZACJI ARKUSZA ZE ZBIORÓW ARCHIWUM ARCHIDIECEZJALNEGO W GNIEŹNIE NA PODSTAWIE ANALIZY ZDOBIĄCYCH GO DRZEWORYTÓWCharakterystyka ułomka znalezionego podczas prac inwentaryzacyjnych w Archiwum Archidiecezjalnym w Gnieźnie w tzw. luzach papierowych. Chronologizacja i identyfi kacja znaleziska na podstawie analizy zdobiących go ilustracji. Dziedzice Marka Szarfenberga czy Maciej Szarfenberg? Hortulus animae czy Horae Beatae Mariae Virginis? A SUPPLEMENT TO THE STUDY OF POLISH PRAYER BOOKS PRINTED IN THE 16TH CENTURY. AN ATTEMPT TO IDENTIFY AND ESTABLISH THE CHRONOLOGY OF A SHEET FROM THE COLLECTION OF THE ARCHDIOCESAN ARCHIVES IN GNIEZNO ON THE BASIS OF ITS WOODCUT DECORATIONSThe article is an attempt to identify a single, much damaged sheet discovered during inventory taking at the Archdiocesan Archives in Gniezno. An analysis of this historical specimen, especially its graphics content, has made it possible to establish that it is a fragment