bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les « langues » de la poésie épigraphique
Authors: Santin Eleonora 
Published: November 2020

Cet article ouvre le dossier « Langue poétique et formes dialectales dans les inscriptions versifiées grecques » qui se compose de sept contributions centrées sur les aspects linguistiques des poèmes épigraphiques. L’objectif de cette introduction est de poser les termes du débat actuel sur un sujet qui n’a jamais été abordé en tant que tel dans un ouvrage collectif et de présenter les apports de la discussion menée lors d’une journée d’étude qui a eu lieu à Lyon le 15 juin 2018. L’intérêt d’un tel dossier réside dans l’approche originale de ses contributions qui ne cherchent pas une norme à tout prix, mais observent une réalité extrêmement nuancée pour y découvrir éventuellement des tendances d’ordre général ou propres à un cadre local ou régional ; le thème des aspects linguistiques des inscriptions versifiées nécessitait d’être exploré à nouveau à la lumière des découvertes archéologiques plus récentes, des nouvelles contributions scientifiques et notamment des acquis sur l’importance des contextes géographique, chronologique, monumental et culturel des textes.
À la recherche d’une langue poétique : les épigrammes préhellénistiques du Péloponnèse
Authors: Guijarro Ruano Paloma 
Published: November 2020

L’objectif de cette étude est d’examiner le contact linguistique qui se produit entre la tradition littéraire ionienne-épique et les dialectes doriens dans la poésie épigraphique péloponnésienne. L’analyse repose sur l’étude des inscriptions votives versifiées datées avant la diffusion de la koinè ionienne-attique ( vii e - iv e siècles av. J.-C.). L’examen de ce corpus nous amène à postuler qu’à la base de ces compositions se trouve une langue mêlée, qui constituait une tentative de création d’une langue poétique différenciée de la langue quotidienne. Mais contrairement à l’opinion la plus répandue, cette langue de compromis ne supprime pas les traits épichoriques. Ainsi, il s’avère que les caractéristiques poétiques héritées de l’épopée ne se justifient que par les contraintes métriques. Inversement, les traits épichoriques affleurent, même dans des contextes où ils altèrent la structure prosodique.
La réforme hospitalière, creuset d’une administration spécialisée. Analyse de la formation et des transformations de la direction des hôpitaux (1970-2010)
Authors: Gay Renaud 
Published: November 2020

Depuis qu’elles se succèdent pour maîtriser la dépense publique à partir des années 1970, les réformes hospitalières affectent la division du travail administratif et la distribution de capacités d’action entre organisations publiques. C’est ainsi que, au fil des réformes, se constitue une direction des hôpitaux au ministère de la santé, puis se définit son domaine d’intervention et s’éprouve son autonomie d’action. Il se dégage de l’analyse trois séquences historiques décrivant un processus discontinu de concentration organisationnelle des tâches administratives auquel peuvent concourir d’autres processus politiques déconnectés des réformes et qui interroge l’homogénéité culturelle de la direction.
Agences régionales de santé : mission impossible
Authors: Pierru Frédéric 
Published: November 2020

Créées en 2010, issues d’une fusion des services déconcentrés de l’État et des services régionaux de l’assurance maladie, les agences régionales de santé (ARS) sont, depuis la crise dite des « gilets jaunes » et, surtout, la pandémie de Covid-19, sur la sellette. À rebours des analyses de type ingénierie administrative, cet article cherche à comprendre la fragilité de ces fausses agences en les ré-encastrant dans leur environnement économique, social et politique. Il souligne en particulier que les ARS sont dans une position structurellement intenable entre l’État central, entré en mode de consolidation budgétaire depuis 2010, et des acteurs « territoriaux » qu’elles ont pour charge de tenir et de piloter à distance. De plus, déjà mal dotées en moyens humains et matériels, elles ont subi le rabot budgétaire alors que leurs missions sont des plus larges. Cet article est donc la chronique de l’échec programmé d’agences n’ayant pas les moyens de répondre aux attentes d’une société sécularisée et politiquement désenchantée pour qui la protection de la vie est devenue une sorte d’idéologie de remplacement.
Les rapports entre établissements d’hébergement pour personnes âgées dépendantes et Agences régionales de santé au prisme de la logique comptable
Authors: Xing-Bongioanni Jingyue 
Published: November 2020

Dans les années 2000, plusieurs réformes ont porté sur la régulation étatique des soins médico-sociaux dans les établissements d’hébergement pour personnes âgées dépendantes (EHPAD), avec notamment l’introduction des outils standardisés comme méthodes tarifaires. Cet article questionne l’impact des réformes néolibérales sur leurs metteurs en œuvre (ici les tarificateurs) et plus particulièrement les rapports entre ces derniers et les gouvernés (ici les EHPAD). Cette étude montre que les nouveaux outils tarifaires ont significativement changé le travail de tarification des EHPAD. En conséquence, les rapports entre les tarificateurs de l’ARS et les directeurs d’EHPAD ont évolué. Désormais, les tarificateurs perçoivent et traitent différemment les EHPAD et leurs gestionnaires, en opposant deux catégories : les excédentaires et les déficitaires. Le modèle de régulation de type « magistrature sociale » laisse place à un modèle de régulation à distance par la logique comptable. Néanmoins, tous les EHPAD ne sont pas soumis aux mêmes règles, on constate des exceptions au profit des établissements influents.
La recherche d’un mode de financement unique des établissements de soins : le mythe de la convergence tarifaire
Authors: Domin Jean-Paul 
Published: November 2020

Ce travail s’intéresse à la mise en œuvre, depuis le début des années 2000, d’un nouveau mode de financement dans les établissements hospitaliers : la tarification à l’activité. Si la convergence tarifaire entre les secteurs publics et privés constitue le mot d’ordre et la cible prioritaire des politiques depuis 2004, il n’en reste pas moins que sa mise en œuvre, d’une part, est assez complexe et, d’autre part, ne tient pas compte des spécificités de chacun des deux secteurs. La mise en œuvre de la convergence tarifaire est d’autant plus délicate que la différence de coûts entre les deux secteurs est aujourd’hui assez bien documentée (effets de taille et de gamme d’activités, caractéristiques des patients, prise en charge des pathologies lourdes...).
Development of a Predictive Model for Role Strain in Registered Nurses Returning to School
Authors: Lengacher Cecile A 
Published: November 2020

ABSTRACT
This study identified the individual characteristics that are expected to predict and explain role strain in registered nurses (IU1Is) returning to school. A model was developed and tested to predict and explain role strain. The characteristics expected to predict role strain were personality, stage of career development, and marital status. Personality was assessed by the Comrey Personality Scales, stage of career development was assessed by the Career Concerns Inventory, and the criterion variable role strain was assessed by the Lengacher Role Strain Inventory. À convenience sample of 123 RN students were asked to participate in the study and 86 RNs volunteered. The data were analyzed using multiple stepwise regression analysis. Results of the stepwise regression analysis identified 13 variables as significant predictors of role strain. A double cross-validation regression procedure was completed to validate the results of the multiple regression analysis. In subsample A of the cross-validation analysis, six variables were found to be significant predictors of role strain, while in subsample B, 12 variables were significant predictors.
Efficacy of vorinostat-sensitized intraperitoneal radioimmunotherapy with 64Cu-labeled cetuximab against peritoneal dissemination of gastric cancer in a mouse model
Authors: Tachibana Tomoko , Yoshii Yukie , Matsumoto Hiroki , Zhang Ming-Rong , Nagatsu Kotaro , Hihara Fukiko , Igarashi Chika , Sugyo Aya , Tsuji Atsushi B. , Higashi Tatsuya 
Published: November 2020

Background:
Gastric cancer is a common cause of cancer-related death worldwide, and peritoneal dissemination is the most frequent metastatic pattern of gastric cancer. However, the treatment of this disease condition remains difficult. It has been demonstrated that intraperitoneal radioimmunotherapy (ipRIT) with 64Cu-labeled cetuximab (anti-epidermal growth factor receptor antibody; 64Cu-cetuximab) is a potential treatment for peritoneal dissemination of gastrointestinal cancer in vivo. Recent preclinical and clinical studies have also shown that a histone deacetylase inhibitor, vorinostat, effectively sensitized gastrointestinal cancer to external radiation.

Aim:
In the present study, we examined the efficacy of the combined use of vorinostat, as a radiosensitizer during ipRIT with 64Cu-cetuximab in a peritoneal dissemination mouse model with human gastric cancer NUGC4 cells stably expressing red fluorescent protein.

Methods:
The mouse model was treated by ipRIT with 64Cu-cetuximab plus vorinostat, each single treatment, or saline (control). Side effects, including hematological and biochemical parameters, were evaluated in similarly treated, tumor-free mice.

Results:
Coadministration of ipRIT with 64Cu-cetuximab + vorinostat significantly prolonged survival compared to control and each single treatment. No significant toxicity signals were observed in all treatment groups.

Conclusions:
Our data suggest that vorinostat is a potentially effective radiosensitizer for use during the treatment of peritoneal dissemination of gastric cancer by ipRIT with 64Cu-cetuximab.
Prognostic factors and clinical nomogram predicting survival in high-grade glioma
Authors: Tunthanathip Thara , Ratanalert Sanguansin , Sae-Heng Sakchai , Oearsakul Thakul , Sakarunchai Ittichai , Kaewborisutsakul Anukoon , Chotsampancharoen Thirachit , Intusoma Utcharee , Kitkhuandee Amnat , Vaniyapong Tanat 
Published: November 2020

Background:
Genomic-based tools have been used to predict poor prognosis high-grade glioma (HGG). As genetic technologies are not generally available in countries with limited resources, clinical parameters may be still necessary to use in predicting the prognosis of the disease. This study aimed to identify prognostic factors associated with survival of patients with HGG. We also proposed a validated nomogram using clinical parameters to predict the survival of patients with HGG.

Methods:
A multicenter retrospective study was conducted in patients who were diagnosed with anaplastic astrocytoma (WHO III) or glioblastoma (WHO IV). Collected data included clinical characteristics, neuroimaging findings, treatment, and outcomes. Prognostic factor analysis was conducted using Cox proportional hazard regression analysis. Then, we used the significant prognostic factors to develop a nomogram. A split validation of nomogram was performed. Twenty percent of the dataset was used to test the performance of the developed nomogram.

Results:
Data from 171 patients with HGG were analyzed. Overall median survival was 12 months (interquartile range: 5). Significant independent predictors included frontal HGG (hazard ratio [HR]: 0.62; 95% confidence interval [CI]: 0.40–0.60), cerebellar HGG (HR: 4.67; 95% CI: 0.93–23.5), (HR: 1.55; 95% CI: 1.03–2.32; reference = total resection), and postoperative radiotherapy (HR: 0.18; 95% CI: 0.10–0.32). The proposed nomogram was validated using nomogram's predicted 1-year mortality rate. Sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and area under the curve of our nomogram were 1.0, 0.50, 0.45, 1.0, 0.64, and 0.75, respectively.

Conclusion:
We developed a nomogram for individually predicting the prognosis of HGG. This nomogram had acceptable performances with high sensitivity for predicting 1-year mortality.
Merkel cell carcinoma in Turkey
Authors: Yildiz Fatih , Demirci Umut , Küçükarda Ahmet , Büyüksimsek Mahmut , Sakalar Teoman , Topcu Turkan Ozturk , Aslan Ferit , Tufan Gulnihal , Aydin Ovgu , Turna Hande , Babacan Nalan Akgul , Basoglu Tugba , Kurt Bediz , Yildiz Birol , Eren Tülay , Demiray Atike Gokcen , Gumusay Ozge , Arslan Cagatay , Özdemir Nuriye , Urun Yuksel , Baykara Meltem , Turan Nedim , Uysal Mukremin , Bilici Ahmet , Kavgaci Halil , Çiçin İrfan , Kilickap Saadettin , Paydas Semra 
Published: November 2020

Background:
Merkel cell carcinoma (MCC) is a rare but highly aggressive neuroendocrine carcinoma of the skin. In this study, we aimed to evaluate the clinicopathologic characteristics, treatment outcomes, and survival of MCC cases in Turkey.

Materials and Methods:
The patients diagnosed with MCC between 1999 and 2018 at twenty different centers in Turkey were included in the study. Patient and tumor characteristics and adjuvant and metastatis treatment outcomes were analyzed retrospectively.

Results:
The median age of totally 89 patients was 70 (26–93). The most common primary location was lower limbs (n = 29, 32.5%). Immunohistochemically, CK20 positivity was present in 59 patients (66.3%). Only two patients had secondary malignancy. The majority of the patients (n = 76, 85.4%) were diagnosed at the localized stage. Surgery was performed for all patients in the early stage, and adjuvant radiotherapy or/and chemotherapy was applied to 52.6% (n = 40) of nonmetastatic patients. The median follow-up was 29 months. Recurrence developed in 21 (27.6%) of the 76 patients who presented with local or regional disease. Two-year disease-free survival (DFS) was 68.1% and 5-year DFS was 62.0% for localized stage. The 5-year DFS was similar for patients receiving adjuvant treatment (chemotherapy, radiotherapy, or sequential chemoradiotherapy) and without adjuvant therapy (P > 0.05). Two-year overall survival in patients who presented with localized disease was 71.3% and 18.5% in metastatic patients (P < 0.001). In the metastatic stage, platinum/etoposide combination was the most preferred combination regimen. Median progression-free survival (PFS) in first-line chemotherapy was 7 months (95% confidence interval: 3.5–10.5 months; standart error: 1.78).

Conclusions:
Although MCC is rare in Turkey, the incidence is increasing. Gender, CK20 status, tumor size, lymph node involvement, and adjuvant treatment were not associated with recurrence.
Benefits of Early In-Hospital Antivenom Administration to Patients with Protobothrops mucrosquamatus Envenomation
Authors: Chuang Po-Chun , Chang Kang-Wei , Cheng Shih-Yu , Pan Hsiu-Yung , Huang Kuo-Chen , Huang Yii-Ting , Li Chao-Jui 
Published: November 2020

ABSTRACTProtobothrops mucrosquamatus is one of the common venomous snakes in Southeast Asia. This retrospective cohort study conducted in six medical institutions in Taiwan aimed to obtain information on the optimal management strategies for P. mucrosquamatus snakebite envenomation. Data were extracted from the Chang Gung Research Database from January 2006 to December 2016. The association between early antivenom administration and patient demographics, pain requiring treatment with analgesic injections, and hospital length of stay was analyzed. A total of 195 patients were enrolled; 130 were administered antivenom within 1 hour after emergency department arrival (early group), whereas 65 were treated later than 1 hour after arrival (late group). No in-hospital mortality was identified. The difference in surgical intervention rates between the early and late groups was statistically insignificant (P = 0.417). Compared with the early group, the late group showed a higher rate of antivenom skin test performance (46.9% versus 63.1%, respectively, P = 0.033), longer hospital stay (42 ± 62 hours versus 99 ± 70 hours, respectively, P = 0.016), and higher rate of incidences of pain requiring treatment with analgesic injections (29.2% versus 46.2%, respectively, P = 0.019). After adjusting for confounding factors, early antivenom administration was associated with decreased pain requiring treatment with analgesic injections (adjusted odds ratio: 0.51, 95% CI: 0.260–0.985). Antivenom administration within 1 hour of arrival was associated with a decreased likelihood of experiencing pain and hospital length of stay in patients with P. mucrosquamatus snakebites. Antivenom skin testing was associated with delays in antivenom administration.
Screening of Twenty-one Ethiopian Medicinal Plants for their Antiproliferative Activity against Human Acute Myeloid Leukemia (MV4-11) Cell Line
Authors: Tesfaye Solomon , Tadesse Solomon , Engidawork Ephrem , Belete Anteneh , Schaufler Katharina , Guenther Sebastian , Asres Kaleab 
Published: November 2020

In vitro antiproliferative activities of the 80% methanol extracts of 21 traditionally used Ethiopian medicinal plants were studied using human acute myeloid leukemia (MV4-11) cell line. Among the tested plants, Euphorbia schimperiana Scheele and Gnidia involucrata Steud. ex A. Rich. exhibited significant antiproliferative activity with GI50 values of 20.6 ± 10.3 μg/ml and 16.6 ± 12.3 μg/ml, respectively. The active extracts were further fractionated using n-hexane, chloroform, ethyl acetate, n-butanol and water, and the antiproliferative assay results indicated that the n-hexane (GI50 = 0.8 ± 0.2 μg/ml) and ethyl acetate (GI50 = 6.1 ± 0.6 μg/ml) fractions of E. schimperiana and G. involucrate, respectively, demonstrated better antiproliferative activity when compared with their respective hydroalcoholic extracts. The findings of this study suggest that further phytochemical studies on the active fractions may lead to the discovery of novel anticancer compounds.
Keywords: antiproliferative activity, Ethiopian medicinal plants, acute myeloid leukemia cell line, Euphorbia schimperiana, Gnidia involucrata
Application of some selected yeasts isolates in bioelectricity generation using Microbial Fuel Cell (MFC)
Authors: Adekanle Margaret. A. , Oloke Julius K. , Adekunle O. Catherine , Oluwakemi Adesiji Y. 
Published: November 2020

Power supply has remained a challeng issue in developing coutries. The aim of this study was to evaluate the potentials of selected yeast species for bioelectricity generation. Different yeast species were isolated from cassava wastewater, whey wastewater, human urine, and rabbit dung using the spread plate method. These isolates were identified using analytical profile index (API). Results obtained revealed the identity of the isolated yeast species as Candida famata, Candida hellenical. Candida tropicalis and Saccharomyces cerevisia (using API method).The isolated yeast species were used singly, and as a consortium for bioelectricity generation, and yeast in continuous mode. The same wastes as used for the isolation process were evaluated as possible substrates for the generation of bioelectricity. Out of the four wastes used, cassava processing wastewater gave the highest bioelectricity potential and was subsequently used as substrate for further study. Saccharomyces cerevisiae elicited the highest electricity generation when the four yeast species were used singly (1.08V). A consortium of the four isolates elicited a synergis effect, generating 1.57V of voltage. Stacking of the Microbial Fuel Cell(MFC) components improved voltage to 2.4V due to its lower internal resistance within the stacked materials. It is apparent from the results obtained in this study that when properly harnessed, microbial fuel cells (MFCs) technology could serve as alternate source of renewable energy.
Keywords: Microbial fuel cells, Waste, yeasts, Salt- Bridge, Nafion117.
Antibacterial Metabolites obtained from fermentation of peanut and cowpea by <i>Lactobacillus</i> spp
Authors: Oyedoh P.O. , Oshoma C.E. , Ikenebumeh M.J. 
Published: November 2020

Lactic acid bacteria elective habitat is food matrix, where they release encrypted metabolites from several parent proteins as a result of their proteolytic activity in the matrix. These metabolites when decrypted confer different bioactive activity thus improving public health. This study was aimed at producing peptide containing metabolites with antibacterial efficacy from defatted cowpea and peanut using Lactobacillus spp. Lactobacillus spp. isolated from spoilt yoghurt were identified using culture dependent and independent method. The isolates were screened for proteolytic ability on skimmed milk agar. The selected isolate with highest proteolytic activity was used for metabolites production through fermentation of defatted cowpea and peanut at 37 oC for 72 h. Parameters analyzed during fermentation were pH, Lactobacillus count, protease activity, peptide concentration and antibacterial activity. The crude peptides produced were assayed for antibacterial activity against bacteria isolated from spoilt meat. From the identified Lactobacillus spp., L. plantarum CAU4347 had the highest proteolytic activity with clear zone of 24.50 ± 0.707 mm. During fermentation the highest and lowest Lactobacillus counts were from cowpea and peanut media with values 294.2 ± 0.21 ×107 and 0.60 ± 0.4 ×107 cfu/ml respectively. Cowpea medium inoculated with L. plantarum CAU4347, had the highest peptide concentration of 79.92 ± 0.01 µg/ml. Consequently, peanut medium showed higher antibacterial activity of 18 mm against Escherichia coli. This result finding suggests that encrypted peptide metabolites from cowpea and peanut flour can confer antibacterial activity against meat spoilage bacteria thus could be utilized as a potential bio-preservative.
Keywords: Metabolites, Cowpea, Peanut, Bioactive, Fermentation, Lactobacillus plantarum
Effect of planting date on the growth, fibre and seed yield of Kenaf (<i>Hibiscus cannabinus</i> L) in Ibadan, South Western Nigeria
Authors: Olanipekun S.O. , Togun A.O. 
Published: November 2020

Planting of kenaf usually commences from March - April as these months mark the onset of the rainy season in Nigeria. On the contrary, it is now difficult for anyone to predict when rain start due to climatic variation. Hence, field experiments was conducted between 2015 and 2016 to determine the appropriate time of sowing kenaf that will optimize its yield potential in South Western Nigeria. As a result of delay in the commencement of rain, planting did not start until May. Hence, kenaf seeds were sown in May, June, July and August at 30 days interval in each year. The experiment was a 4 × 2 factorial laid out in a randomized complete block design and replicated three times. The result indicated that the highest fibre yield (1.00 t/ha) was from the kenaf sown in June irrespective of the year, but not significantly different from the one sown in July (0.98 t/ha). On the other hand, kenaf sown in July had the highest seed yield (2.28 t/ha) with the lowest seed yield (1.04 t/ha) obtained in May followed by August (1.19 t/ha). The experiment conclusively affirm June for sowing of kenaf for fibre cultivation and July for seed production.
Keywords: Planting date, kenaf, fibre and seed yield