bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical characteristics of 10 children with a pediatric inflammatory multisystem syndrome associated with COVID-19 in Iran
Authors: Shahbaznejad Leila , Navaeifar Mohammad Reza , Abbaskhanian Ali , Hosseinzadeh Fatemeh , Rahimzadeh Golnar , Rezai Mohammad Sadegh 
Published: November 2020

AbstractBackgroundAlthough symptoms and signs of COVID-19 (Coronavirus disease 2019) in children are milder than adults, there are reports of more severe cases which were defined as pediatric inflammatory multisystem syndrome (PIMS). The purpose of this report was to describe the possible association between COVID-19 and PIMS in children.MethodsFrom 28 March to 24 June 2020, 10 febrile children were admitted with COVID-19 infection showing characteristics of PIMS in Buali tertiary hospital of Sari, in Mazandaran province, northern Iran. Demographic and clinical characteristics, laboratory and imaging findings, and therapeutic modalities were recorded and analyzed.ResultsThe mean age of the patients was 5.37 ± 3.9 years (13 months to 12 years). Six of them were boys. Kawasaki disease, myocarditis, toxic shock syndrome, appendicitis, sepsis, urosepsis, prolonged febrile seizure, acute hemorrhagic edema of infancy, and COVID-19-related pneumonia were their first presentation. All of them had increased C-reactive protein levels, and most of them had elevated erythrocyte sedimentation rate, lymphopenia, anemia, and hypoalbuminemia. Three of them had thrombocytopenia(PLT < 106). Six of them were serologically or polymerase chain reaction positive for COVID-19, and 4 of them were diagnosed as COVID-19 just by chest computed tomography scan. Most of the patients improved without a residual sequel, except one who died with multiorgan failure and another case was discharged with a giant coronary aneurysm.ConclusionsChildren with COVID-19 may present symptoms similar to Kawasaki disease and inflammatory syndromes. PIMS should be considered in children with fever, rash, seizure, cough, tachypnea, and gastrointestinal symptoms such as vomiting, diarrhea, and abdominal pain.
Ethnic disparities in receiving benefits for disability following postpartum mental illness during first two years after delivery: an Israeli nationwide study
Authors: Savitsky Bella , Radomislensky Irina , Frid Zhanna , Gitelson Natalia , Glasser Saralee , Hendel Tova 
Published: November 2020

Abstract

Background
Despite relatively high rates of Postpartum Depression (PPD), little is known about the granting of social security benefits to women who are disabled as a result of PPD or of other postpartum mood and anxiety disorders (PMAD). This study aims to identify populations at risk for underutilization of social security benefits due to PMAD among Israeli women, with a focus on ethnic minorities.

Methods
This retrospective cohort study is based on the National Insurance Institute (NII) database. The study population included a simple 10% random sample of 79,391 female Israeli citizens who gave birth during 2008–2016 (these women delivered a total of 143,871 infants during the study period), and who had not been eligible for NII mental health disability benefits before 2008.
The dependent variable was receipt of Benefit Entitlement (BE) due to mental illness within 2 years following childbirth. Maternal age at delivery, population group, Socio-Economic Status (SES), family status, employment status of the mother and her spouse, and infant mortality were the independent variables. Left truncation COX proportional hazard model with time-dependent variables was used, and birth number served as a time discrete variable.

Results
Bedouin and Arab women had significantly lower likelihood of BE (2.6 times lower and twice lower) compared with other ethnic groups (HR = 0.38; 95% CI: 0.26–0.56; HR = 0.47; 95% CI: 0.37–0.60 respectively). The probability of divorced or widowed women for BE was significantly higher compared to those living with a spouse (HR = 3.64; 95% CI: 2.49–5.33). Lack of employment was associated with higher likelihood of BE (HR = 1.54; 95% CI: 1.30–1.82). Income had a dose-response relationship with BE in multivariable analysis: lower income was associated with the nearly four-fold greater probability compared to the highest income quartile (HR = 3.83; 95% CI: 2.89–5.07).

Conclusions
Despite the exceptionally high prevalence of PMAD among ethnic minorities, Bedouins and Arabs had lowest likelihood of Benefit Entitlement. In addition to developing programs for early identification of postpartum emotional disorders among unprivileged ethnic groups, awareness regarding entitlement to a mental health disability allowance among ethnic minorities should be improved.
Evidence of integrated primary-secondary health care in low-and middle-income countries: protocol for a scoping review
Authors: Hasan Md Zabir , Singh Shalini , Arora Dinesh , Jain Nishant , Gupta Shivam 
Published: November 2020

Abstract

Background
Integrated care is a people-centered health delivery approach that ensures the comprehensiveness, quality, and continuity of service across the settings and levels of health systems. The World Health Organization (WHO) recommends integration across levels and building-blocks of health systems as a prerequisite of Universal Health Coverage (UHC). While health systems of low- and middle-income countries (LMICs) are often fragmented and led by siloed service delivery structure, several LMICs—including India—have attempted health system integration. Several systematic reviews of evidence on healthcare integration from developed countries exist, but no synthesis from LMICs was reported to date. This review will overview the existing evidence of primary-secondary care integration (PSI) in the context of LMICs, aiming to support policy decisions for the effective integration of health delivery systems in India.

Methods
The review will be conducted following the six steps recommend by Arksey and O'Malley. Scientific and grey literature will be systematically selected from PubMed, Embase, Scopus, Web of Science, Global Index Medicus, and electronic repositories (such as WHO, World Bank, Health Policy Plus, and OpenGrey). Using a comprehensive search strategy, literature written in English and published between 2000 and 2020 will be selected, and two independent authors will screen their titles and abstracts. The result will be charted using a data extraction form and reported using tables, figures, and narrative forms.

Discussion
No ethical approval is necessary for the review. The final report will be developed with the consultation of other stakeholders and disseminated through workshops, conference papers, and peer review articles. The review will serve as a guiding tool to approach, implement, and test the PSI models in India and other LMICs.

Scoping review registration
https://osf.io/kjhzt.
Epidemiological factors of septoria tritici blotch (Zymoseptoria tritici) in durum wheat (Triticum turgidum) in the highlands of Wollo, Ethiopia
Authors: Hailemariam Bogale Nigir , Kidane Yosef Geberehawariat , Ayalew Amare 
Published: November 2020

Abstract

Background
Septoria tritici blotch (STB) (Zymoseptoria tritici) is a major disease of durum wheat, an economic crop grown in the highlands of Wollo in Ethiopia.

Methods
To determine the status of this disease, we conducted surveys in five districts of Wollo (Meket, Woreilu, Wadila, Jama, and Dessie Zuria) during the 2015 cropping season. We visited 75 farm plots to determine the prevalence, incidence, and severity of STB.

Results
STB prevalence varied among locations, genotypes, planting dates, growth stages, previous crops, plant population, weed population, and soil types. Similarly, disease intensity also varied along all independent variables. The level of incidence was high in all the visited districts, and the level severity ranged from 9.9 to 59.3% while the incidence varied from 50 to 100%. The mean differences in incidence and severity within the districts’ variable classes, altitude, varieties, growth stage, plant population, planting date, previous crop, weed population, and soil type were high. The independent variables, districts, altitude, varieties, growth stage, plant population, planting date, previous crops, weed population, and soil type, were significantly associated with high incidence and severity of STB as single predictor in the logistic regression model. A reduced multiple variable model was fitted using districts, altitude, varieties, growth stage, plant population, planting date, previous crop, weed population, and soil type as independent variables. High incidence (> 50%) and severity (> 25%) had a high probability of association to all independent variables, except previous crop. Low disease incidence (≤ 50%) and low disease severity (≤ 25%) had high probability of association to the previous crop.

Conclusion
Environmental variables, cultivation practice, and responses were important for the development of STB. Therefore, these factors must be considered in designing strategies for the effective management of STB.
Present and future suitability of the Lake Tana Biosphere Reserve in Ethiopia for the Nile monitor (Varanus niloticus) using the MaxEnt model
Authors: Ejigu Dessalegn , Tassie Nega 
Published: November 2020

Abstract

Introduction
The Nile monitor (Varanus niloticus) is the largest lizard native to Sub-Saharan Africa along the Nile River. The species inhabits a wide variety of habitats including woodlands, grasslands, mangroves, and swamps. Although the practice is not common in the Lake Tana Biosphere Reserve, the species is being hunted in Sahelian Africa for its leather, food, and pet trade. Consequently, the species is listed under the Convention on International Trade in Endangered Species.

Methodology
Data collection was based on onsite GIS aided presence recording. Each record of the species was first vetted for data quality. A multicollinearity analysis was conducted before fitting the MaxEnt model to the 19 bioclimatic variables. Since it provides good coverage for Africa, the Hadley Global Environment Model 2-Atmosphere Ocean (HadGEM2-AO) model was used for extracting future climate scenarios. The implementation of change factor was to correct the modeled mean climate from the climate models. The jackknife test was selected to measure the contribution of each environmental predictor variable. Area under the curve of the receiver operating characteristic was used to evaluate the performance of MaxEnt model.

Results
On average 2750 individuals of Nile monitor were recorded within the Lake Tana Biosphere Reserve. Mean annual temperature, precipitation and temperature were the most important predictors that limit the potential distribution of Nile monitor in the area. Most of the suitable habitats of Nile monitor were mainly predicted in the northern parts of Lake Tana. The ecological niche model produced an average AUC of 0.85. Notable records of the species were found in the vicinity of the lake and the nearby wetlands. Future projection of potential suitable areas revealed that the currently available suitable area to Nile monitor will decline in both 2050 and 2070 under both RCP 6.5 and RCP 8.5, of which the decline in suitable area under the business as usual scenario is the greatest.

Conclusion
The potential distribution map for Nile monitor in the Lake Tana Biosphere Reserve can help in planning land use management around its existing habitat range, discover new populations or set priorities to restore its natural habitat for more effective conservation. Extensive reductions in the amount of suitable areas under future climate scenarios suggest that the species may become threatened in future if effective conservation measures are not implemented.
Aldh1l2 knockout mouse metabolomics links the loss of the mitochondrial folate enzyme to deregulation of a lipid metabolism observed in rare human disorder
Authors: Krupenko Natalia I. , Sharma Jaspreet , Pediaditakis Peter , Helke Kristi L. , Hall Madeline S. , Du Xiuxia , Sumner Susan , Krupenko Sergey A. 
Published: November 2020

AbstractBackgroundMitochondrial folate enzyme ALDH1L2 (aldehyde dehydrogenase 1 family member L2) converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2simultaneously producing NADPH. We have recently reported that the lack of the enzyme due to compound heterozygous mutations was associated with neuro-ichthyotic syndrome in a male patient. Here, we address the role of ALDH1L2 in cellular metabolism and highlight the mechanism by which the enzyme regulates lipid oxidation.MethodsWe generatedAldh1l2knockout (KO) mouse model, characterized its phenotype, tissue histology, and levels of reduced folate pools and applied untargeted metabolomics to determine metabolic changes in the liver, pancreas, and plasma caused by the enzyme loss. We have also used NanoString Mouse Inflammation V2 Code Set to analyze inflammatory gene expression and evaluate the role of ALDH1L2 in the regulation of inflammatory pathways.ResultsBoth male and femaleAldh1l2KO mice were viable and did not show an apparent phenotype. However, H&E and Oil Red O staining revealed the accumulation of lipid vesicles localized between the central veins and portal triads in the liver ofAldh1l2-/-male mice indicating abnormal lipid metabolism. The metabolomic analysis showed vastly changed metabotypes in the liver and plasma in these mice suggesting channeling of fatty acids away from β-oxidation. Specifically, drastically increased plasma acylcarnitine and acylglycine conjugates were indicative of impaired β-oxidation in the liver. Our metabolomics data further showed that mechanistically, the regulation of lipid metabolism by ALDH1L2 is linked to coenzyme A biosynthesis through the following steps. ALDH1L2 enables sufficient NADPH production in mitochondria to maintain high levels of glutathione, which in turn is required to support high levels of cysteine, the coenzyme A precursor. As the final outcome, the deregulation of lipid metabolism due to ALDH1L2 loss led to decreased ATP levels in mitochondria.ConclusionsThe ALDH1L2 function is important for CoA-dependent pathways including β-oxidation, TCA cycle, and bile acid biosynthesis. The role of ALDH1L2 in the lipid metabolism explains why the loss of this enzyme is associated with neuro-cutaneous diseases. On a broader scale, our study links folate metabolism to the regulation of lipid homeostasis and the energy balance in the cell.
Genetic and epigenetic landscape of IDH-wildtype glioblastomas with FGFR3-TACC3 fusions
Authors: Mata Douglas A. , Benhamida Jamal K. , Lin Andrew L. , Vanderbilt Chad M. , Yang Soo-Ryum , Villafania Liliana B. , Ferguson Donna C. , Jonsson Philip , Miller Alexandra M. , Tabar Viviane , Brennan Cameron W. , Moss Nelson S. , Sill Martin , Benayed Ryma , Mellinghoff Ingo K. , Rosenblum Marc K. , Arcila Maria E. , Ladanyi Marc , Bale Tejus A. 
Published: November 2020

Abstract
A subset of glioblastomas (GBMs) harbors potentially druggable oncogenic FGFR3-TACC3 (F3T3) fusions. However, their associated molecular and clinical features are poorly understood. Here we analyze the frequency of F3T3-fusion positivity, its associated genetic and methylation profiles, and its impact on survival in 906 IDH-wildtype GBM patients. We establish an F3T3 prevalence of 4.1% and delineate its associations with cancer signaling pathway alterations. F3T3-positive GBMs had lower tumor mutational and copy-number alteration burdens than F3T3-wildtype GBMs. Although F3T3 fusions were predominantly mutually exclusive with other oncogenic RTK pathway alterations, they did rarely co-occur with EGFR amplification. They were less likely to harbor TP53 alterations. By methylation profiling, they were more likely to be assigned the mesenchymal or RTK II subclass. Despite being older at diagnosis and having similar frequencies of MGMT promoter hypermethylation, patients with F3T3-positive GBMs lived about 8 months longer than those with F3T3-wildtype tumors. While consistent with IDH-wildtype GBM, F3T3-positive GBMs exhibit distinct biological features, underscoring the importance of pursuing molecular studies prior to clinical trial enrollment and targeted treatment.
Looking across health and healthcare outcomes for people with intellectual and developmental disabilities and psychiatric disorders: population-based longitudinal study
Authors: Lin Elizabeth , Balogh Robert , Chung Hannah , Dobranowski Kristin , Durbin Anna , Volpe Tiziana , Lunsky Yona 
Published: November 2020

BackgroundIntellectual and developmental disabilities (IDDs) and psychiatric disorders frequently co-occur. Although each has been associated with negative outcomes, their combined effect has rarely been studied.AimsTo examine the likelihood of five negative health and healthcare outcomes for adults with IDD and mental health/addiction disorders (MHAs), both separately and together. For each outcome, demographic, clinical and system-level factors were also examined.MethodLinked administrative data-sets were used to identify adults in Ontario, Canada, with IDD and MHA (n = 29 476), IDD-only (n = 35 223) and MHA-only (n = 727 591). Five outcomes (30-day readmission, 30-day repeat ED visit, delayed discharge, long-term care admission and premature mortality) were examined by logistic regression models with generalised estimating equation or survival analyses. For each outcome, crude (disorder groups only) and complete (adding biosocial covariates) models were run using a general population reference group.ResultsThe IDD and MHA group had the highest proportions across outcomes for both crude and complete models. They had the highest adjusted ratios for readmissions (aOR 1.93, 95%CI 1.88–1.99), repeat ED visit (aOR 2.00, 95%CI 1.98–2.02) and long-term care admission (aHR 12.19, 95%CI 10.84–13.71). For delayed discharge, the IDD and MHA and IDD-only groups had similar results (aOR 2.00 (95%CI 1.90–2.11) and 2.21 (95%CI 2.07–2.36). For premature mortality, the adjusted ratios were similar for all groups.ConclusionsPoorer outcomes for adults with IDD, particularly those with MHA, suggest a need for a comprehensive, system-wide approach spanning health, disability and social support.
Further investigation of gateway effects using the PATH study
Authors: Lee Peter N , Fry John S 
Published: November 2020

Background: Interest exists in whether youth e-cigarette use (“vaping”) increases risk of initiating cigarette smoking. Using Waves 1 and 2 of the US PATH study we previously reported adjustment for vaping propensity using Wave 1 variables explained about 80% of the unadjusted relationship. Here data from Waves 1 to 3 are used to avoid over-adjustment if Wave 1 vaping affected variables recorded then. Methods: Main analyses M1 and M2 concerned Wave 2 never smokers who never vaped by Wave 1, linking Wave 2 vaping to Wave 3 smoking initiation, adjusting for predictors of vaping based on Wave 1 data using differing propensity indices. M3 was similar but derived the index from Wave 2 data. Sensitivity analyses excluded Wave 1 other tobacco product users, included other product use as another predictor, or considered propensity for smoking or any tobacco use, not vaping. Alternative analyses used exact age (not previously available) as a confounder not grouped age, attempted residual confounding adjustment by modifying predictor values using data recorded later, or considered interactions with age. Results: In M1, adjustment removed about half the excess OR (i.e. OR–1), the unadjusted OR, 5.60 (95% CI 4.52-6.93), becoming 3.37 (2.65-4.28), 3.11 (2.47-3.92) or 3.27 (2.57-4.16), depending whether adjustment was for propensity as a continuous variable, as quintiles, or the variables making up the propensity score. Many factors had little effect: using grouped or exact age; considering other products; including interactions; or using predictors of smoking or tobacco use rather than vaping. The clearest conclusion was that analyses avoiding over-adjustment explained about half the excess OR, whereas analyses subject to over-adjustment explained about 80%. Conclusions: Although much of the unadjusted gateway effect results from confounding, we provide stronger evidence than previously of some causal effect of vaping, though doubts still remain about the completeness of adjustment.
The effects of touch-screen technology usage on hand skills among preschool children: a case-control study
Authors: Daud Ahmad Zamir Che , Aman Nurul Afiq'ah , Chien Chi-Wen , Judd Jenni 
Published: November 2020

Background: Little is known on how time spent on touch-screen technology affects the hand skills development of preschool children. This study aimed to investigate the effects of touch-screen technology usage on hand skills among preschool children. Methods: Case-control design was employed to compare the hand skills of children who were engaged in touch-screen technology. A total of 128 participants aged between five and six years old who attended preschool were recruited and divided into two groups: high usage touch-screen technology (HUTSTG) and, low usage touch-screen technology (LUTSTG). Children's Hand Skills ability Questionnaire (CHSQ) and Assessment of Children's Hand Skills (ACHS) were used to evaluate the children's hand skills. Results: There were significant differences in the hand skills of preschool children between HUTSTG and LUTSTG. Results showed that preschool children in LUTSTG had better hand skills in all domains of CHSQ (p≤0.001) and ACHS (p<0.001) as compared to HUTSTG. Conclusion: Frequent use of touch-screen technology might cause disadvantages to the development of hand skills among preschool children.
Cues, Values and Conflict: Reassessing Evolution Wars Media Persuasion
Authors: Aechtner Thomas 
Published: November 2020

It has been posited that persuasive cues impart Evolution Wars communications with persuasive force extending beyond the merits of their communicated arguments. Additionally, it has been observed that the array of cues displayed throughout proevolutionist materials is exceeded in both the number and nuance of Darwin-skeptic persuasion techniques. This study reassesses these findings by exploring how persuasive cues in the Evolution Wars are being articulated with reference to the Cultural Cognition Thesis and Moral Foundations Theory. Observations of Institute for Creation Research, Answers in Genesis, and the Center for Science and Culture media are reevaluated. These findings are juxtaposed with data pertaining to Richard Dawkins Foundation for Reason and Science, National Center for Science Education, and BioLogos Foundation broadcasts. The outcomes reveal how values claims and morally charged language are concentrated within the works of antievolutionists and New Atheist media makers, who collectively promote some manner of religion-science conflict.