bluuebunny/crossref_metadata_2025_split huggingface dataset:
A host–guest approach to combining enzymatic and artificial catalysis for catalyzing biomimetic monooxygenation
Authors: Zhao Liang , Cai Junkai , Li Yanan , Wei Jianwei , Duan Chunying 
Published: June 2020

AbstractDirect transfer of protons and electrons between two tandem reactions is still a great challenge, because overall reaction kinetics is seriously affected by diffusion rate of the proton and electron carriers. We herein report a host–guest supramolecular strategy based on the incorporation of NADH mimics onto the surface of a metal-organic capsule to encapsulate flavin analogues for catalytic biomimetic monooxygenations in conjunction with enzymes. Coupling an artificial catalysis and a natural enzymatic catalysis in the pocket of an enzyme, this host–guest catalyst–enzyme system allows direct proton and electron transport between two catalytic processes via NADH mimics for the monooxygenation of both cyclobutanones and thioethers. This host–guest approach, which involves the direct coupling of abiotic and biotic catalysts via a NADH-containing host, is quite promising compared to normal catalyst–enzyme systems, as it offers the key advantages of supramolecular catalysis in integrated chemical and biological synthetic sequences.
Efficient removal of As(V) from aqueous media by magnetic nanoparticles prepared with Iron-containing water treatment residuals
Authors: Zeng Huiping , Zhai Longxue , Qiao Tongda , Yu Yaping , Zhang Jie , Li Dong 
Published: June 2020

AbstractTwo types of magnetic nanoparticles prepared with chemical agents (cMNP) and iron-containing sludge (iMNP), respectively, were synthesized by co-precipitation process and used to remove arsenate [As(V)] from water. The synthesized magnetic adsorbents were characterized by XRD, XPS, TEM, BET, VSM and FTIR. The adsorbents iMNP and cMNP were both mainly γ-Fe2O3 in nanoscale particles with the saturation magnetization of 35.5 and 69.0 emu/g respectively and could be easily separated from water with a simple hand-held magnet in 2 minutes. At pH 6.6, over 90% of As(V), about 400 μg/L, could be removed by both adsorbents (0.2 g/L) within 60 min. The adsorption isotherm of both fabricated materials could be better described by the Langmuir adsorption isotherm model than the Freundlich’s, In addition, the adsorption kinetics of both adsorbents described well by the pseudo-second order model revealed that the intraparticle diffusion was not just the only rate controlling step in adsorption process. With the larger maximum As(V) adsorption capacity of iMNP (12.74 mg/g), compared with that of cMNP (11.76 mg/g), the iMNP could be regarded as an environmentally friendly substitute for the traditional magnetic nanoparticles prepared with chemical agents.
Anticholinergic Burden in Children, Adults and Older Adults in Slovenia: A Nationwide Database Study
Authors: Cebron Lipovec Nanca , Jazbar Janja , Kos Mitja 
Published: June 2020

AbstractAnticholinergic burden has been widely studied in specific patient populations with specific conditions. However, the prevalence in the general population is poorly understood. This retrospective cross-sectional study was a nationwide database analysis of outpatient prescriptions of anticholinergic medications. The study was based on Slovenian health claims data of all outpatient prescriptions in 2018. Anticholinergic burden was evaluated using the Anticholinergic Cognitive Burden scale. Three age groups were analysed: children (≤18 years), adults (19–64 years) and older adults (≥65 years). Anticholinergic medications were prescribed to 29.8% of the participants; 7.6% were exposed to a clinically significant anticholinergic burden. The proportion of patients exposed to anticholinergic burden was highest in older adults (43.2%), followed by adults (25.8%) and children (20.7%). The most frequently prescribed medications with the highest anticholinergic activity were antipsychotics and medications for urinary diseases (42.8% and 40.2%, respectively). Medications with second highest activity were mostly antiepileptics (87.3%). Medications with possible anticholinergic activity included diverse therapeutic groups. Anticholinergic burden is highest in older adults but is also considerable among adults and children. Medications with anticholinergic activity belong to diverse therapeutic groups. Further research is needed on safe use of these medications in all age groups.
Anaesthetic-dependent changes in gene expression following acute and chronic exposure in the rodent brain
Authors: Upton Dannielle H. , Popovic Kata , Fulton Roger , Kassiou Michael 
Published: June 2020

AbstractAnaesthesia has been predicted to affect gene expression of the memory-related regions of the brain including the primary visual cortex. It is also believed that anaesthesia causes inflammation of neural tissues, increasing elderly patients’ chances of developing precursor lesions that lead to Alzheimer’s disease and other neurodegeneration related diseases. We have analyzed the expression of over 22,000 genes and 129,800 transcripts using oligonucleotide microarrays to examine the brain expression profiles in Sprague Dawley rats following exposure to acute or chronic doses of the anaesthetics isoflurane, ketamine and propofol. Here we report for the first time molecular and genomic data on the effect on the rodent brain of chronic and acute exposure to isoflurane, ketamine and propofol. Our screen identified multiple genes that responded to all three anaesthetics. Although some of the genes were previously known to be anaesthesia responsive, we have for the most part identified novel genes involved in the acute and chronic rodent brain response to different anaesthesia treatments. The latter may be useful candidate genes in the search to elucidate the molecular pathways mediating anaesthetic effects in the brain and may allow us to identify mechanisms by which anaesthetics could impact on neurodegeneration.
Hybrid nanofluid flow towards a stagnation point on a stretching/shrinking cylinder
Authors: Waini Iskandar , Ishak Anuar , Pop Ioan 
Published: June 2020

AbstractThis paper examines the stagnation point flow towards a stretching/shrinking cylinder in a hybrid nanofluid. Here, copper (Cu) and alumina (Al2O3) are considered as the hybrid nanoparticles while water as the base fluid. The governing equations are reduced to the similarity equations using a similarity transformation. The resulting equations are solved numerically using the boundary value problem solver, bvp4c, available in the Matlab software. It is found that the heat transfer rate is greater for the hybrid nanofluid compared to the regular nanofluid as well as the regular fluid. Besides, the non-uniqueness of the solutions is observed for certain physical parameters. It is also noticed that the bifurcation of the solutions occurs in the shrinking regions. In addition, the heat transfer rate and the skin friction coefficients increase in the presence of nanoparticles and for larger Reynolds number. It is found that between the two solutions, only one of them is stable as time evolves.
Mudstone creep experiment and nonlinear damage model study under cyclic disturbance load
Authors: Wang Jun-guang , Sun Qing-lin , Liang Bing , Yang Peng-jin , Yu Qing-rong 
Published: June 2020

AbstractTo study the creep characteristics of mudstone under disturbed load, creep rock triaxial compression disturbance tests under different disturbance amplitudes and frequencies are conducted using a self-made triaxial disturbed creep test bench for rock. The influence of different factors on the creep deformation law of each stage is analyzed. The results show that the disturbance effect has a significant impact on the creep properties of mudstone, and various factors have different effects on the creep stages. The instantaneous deformation variable, creep decay time, and steady creep rate change exponentially with the increase in axial pressure, and increase linearly with the increase in disturbance amplitude and disturbance frequency. The disturbance amplitude has a more significant effect on the instantaneous deformation, steady-state creep rate, and accelerated creep. According to the analysis of the test results, a nonlinear disturbance creep damage model based on Burger’s model is established. The model is identified and calculated by the improved least squares method based on pattern search. The influence of different disturbance factors on the creep parameters is analyzed. The model fitting results and experimental results are compared to demonstrate that the model is used to simulate different disturbances. It was observed that rock creep under certain conditions exhibits certain adaptability. It is of great significance to carry out rock disturbance creep experiments and study the theory of disturbance creep to ensure the long-term stability of deep rock mass in complex environment.
Serum adropin levels are reduced in patients with inflammatory bowel diseases
Authors: Brnić Darko , Martinovic Dinko , Zivkovic Piero Marin , Tokic Daria , Tadin Hadjina Ivana , Rusic Doris , Vilovic Marino , Supe-Domic Daniela , Tonkic Ante , Bozic Josko 
Published: June 2020

AbstractAdropin is a novel peptide mostly associated with energy homeostasis and vascular protection. To our knowledge, there are no studies that investigated its relationship with inflammatory bowel diseases (IBD). The aim of this study was to compare serum adropin levels between 55 patients with IBD (30 Ulcerative colitis (UC) patients, 25 Crohn’s disease (CD) patients) and 50 age/gender matched controls. Furthermore, we explored adropin correlations with IBD severity scores, hsCRP, fecal calprotectin, fasting glucose and insulin levels. Serum adropin levels were significantly lower in patients with IBD in comparison with the control group (2.89 ± 0.94 vs 3.37 ± 0.60 ng/mL,P = 0.002), while there was no significant difference in comparison of UC patients with CD patients (P = 0.585). Furthermore, there was a negative correlation between adropin and fecal calprotectin (r = −0.303,P = 0.025), whereas in the total study population, we found a significant negative correlation with fasting glucose levels (r = −0.222,P = 0.023). A multivariable logistic regression showed that serum adropin was a significant predictor of positive IBD status when enumerated along with baseline characteristics (OR 0.455, 95% CI 0.251–0.823,P = 0.009). Our findings imply that adropin could be involved in complex pathophysiology of IBD, but further larger scale studies are needed to address these findings.
Future increase in elderly heat-related mortality of a rapidly growing Asian megacity
Authors: Varquez Alvin Christopher G. , Darmanto Nisrina S. , Honda Yasushi , Ihara Tomohiko , Kanda Manabu 
Published: June 2020

AbstractUrban dwellers are at risk of heat-related mortality in the onset of climate change. In this study, future changes in heat-related mortality of elderly citizens were estimated while considering the combined effects of spatially-varying megacity’s population growth, urbanization, and climate change. The target area is the Jakarta metropolitan area of Indonesia, a rapidly developing tropical country. 1.2 × 1.2 km2 daily maximum temperatures were acquired from weather model outputs for the August months from 2006 to 2015 (present 2010s) and 2046 to 2055 (future 2050s considering pseudo-global warming of RCP2.6 and RCP8.5). The weather model considers population-induced spatial changes in urban morphology and anthropogenic heating distribution. Present and future heat-related mortality was mapped out based on the simulated daily maximum temperatures. The August total number of heat-related elderly deaths in Jakarta will drastically increase by 12~15 times in the 2050s compared to 2010s because of population aging and rising daytime temperatures under “compact city” and “business-as-usual” scenarios. Meanwhile, mitigating climate change (RCP 2.6) could reduce the August elderly mortality count by up to 17.34%. The downwind areas of the densest city core and the coastal areas of Jakarta should be avoided by elderly citizens during the daytime.
Pneumonia-induced endothelial amyloids reduce dendritic spine density in brain neurons
Authors: Scott Allison M. , Jager Alexandrea C. , Gwin Meredith , Voth Sarah , Balczon Ron , Stevens Troy , Lin Mike T. 
Published: June 2020

AbstractPseudomonas aeruginosa pneumonia elicits endothelial cell release of cytotoxic amyloids that can be recovered from the bronchoalveolar lavage and cerebrospinal fluids of critically ill patients. Introduction of these cytotoxic amyloids into the lateral ventricle impairs learning and memory in mice. However, it is unclear whether the amyloids of lung origin (1) are neurotropic, and (2) cause structural remodeling of hippocampal dendrites. Thus, we used electrophysiological studies in brain slices and structural analysis of post-mortem tissues obtained from animals exposed to endothelium-derived amyloids to assess these issues. The amyloids were administered via three different routes, by intracerebroventricular, intratracheal, and intraperitoneal injections. Synaptic long-term potentiation was abolished following intracerebroventricular amyloid injection. Fluorescence dialysis or Golgi-impregnation labeling showed reduced dendritic spine density and destabilized spines of hippocampal pyramidal neurons 4 weeks after intracerebroventricular amyloid injection. In comparison, endothelial amyloids introduced to the airway caused the most prominent dendritic spine density reduction, yet intraperitoneal injection of these amyloids did not affect spine density. Our findings indicate that infection-elicited lung endothelial amyloids are neurotropic and reduce neuronal dendritic spine density in vivo. Amyloids applied into the trachea may either be disseminated through the circulation and cross the blood-brain barrier to access the brain, initiate feed-forward amyloid transmissibility among cells of the blood-brain barrier or access the brain in other ways. Nevertheless, lung-derived amyloids suppress hippocampal signaling and cause injury to neuronal structure.
The patient demographics, radiographic index and surgical invasiveness for mechanical failure (PRISM) model established for adult spinal deformity surgery
Authors: Yagi Mitsuru , Hosogane Naobumi , Fujita Nobuyuki , Okada Eijiro , Suzuki Satoshi , Tsuji Osahiko , Nagoshi Narihito , Nakamura Masaya , Matsumoto Morio , Watanabe Kota 
Published: June 2020

AbstractMechanical failure (MF) following adult spinal deformity (ASD) surgery is a severe complication and often requires revision surgery. Predicting a patient’s risk of MF is difficult, despite several potential risk factors that have been reported. The purpose of this study was to establish risk stratification model for predicting the MF based on demographic, and radiographic data. This is a multicenter retrospective review of the risk stratification for MF and included 321 surgically treated ASD patients (55 ± 19 yr, female: 91%). The analyzed variables were recorded for at least 2 yr and included age, gender, BMI, BMD, smoking status, frailty, fusion level, revision surgery, PSO, LIF, previous surgery, spinal alignment, GAP score, Schwab-SRS type, and rod materials. Multivariate logistic regression analyses were performed to identify the independent risk factors for MF. Each risk factor was assigned a value based on its regression coefficient, and the values of all risk factors were summed to obtain the PRISM score (range 0–12). We used an 8:2 ratio to split the data into a training and a testing cohort to establish and validate the model. MF developed in 41% (n = 104) of the training subjects. Multivariate analysis revealed that BMI, BMD, PT, and frailty were independent risk factors for MF (BMI: OR 1.7 [1.0–2.9], BMD: OR 3.8 [1.9–7.7], PT: OR 2.6 [1.8–3.9], frailty: OR 1.9 [1.1–3.2]). The MF rate increased with and correlated well with the risk grade as shown by ROC curve (AUC of 0.81 [95% CI 0.76–0.86]). The discriminative ability of the score in the testing cohort was also good (AUC of 0.86 ([95% CI 0.77–0.95]). We successfully developed an MF-predicting model from individual baseline parameters. This model can predict a patient’s risk of MF and will help surgeons adjust treatment strategies to mitigate the risk of MF.
Super Sub-Nyquist Single-Pixel Imaging by Total Variation Ascending Ordering of the Hadamard Basis
Authors: Yu Xiao , Stantchev Rayko Ivanov , Yang Fan , Pickwell-MacPherson Emma 
Published: June 2020

AbstractSingle pixel imaging (SPI) captures images without array detectors or raster scanning. When combined with compressive sensing techniques it enables novel solutions for high-speed optical imaging and spectroscopy. However, when it comes to the real-time capture and analysis of a fast event, the challenge is the inherent trade-off between frame rate and image resolution. Due to the lack of sufficient sparsity and the intrinsic iterative process, conventional compressed sensing techniques have limited improvement in capturing natural scenes and displaying the images in real time. In this work, we demonstrate a novel alternative compressive imaging approach employing an efficient and easy-implementation sampling scheme based on reordering the deterministic Hadamard basis through their total variation. By this means, the number of measurements and acquisition are reduced significantly without needing complex minimization algorithms. We can recover a 128 × 128 image with a sampling ratio of 5% at the signal peak signal-to-noise ratio (PSNR) of 23.8 dB, achieving super sub-Nyquist sampling SPI. Compared to other widely used sampling e.g. standard Hadamard protocols and Gaussian matrix methods, this approach results in a significant improvement both in the compression ratio and image reconstruction quality, enabling SPI for high frame rate imaging or video applications.
Ultra High-efficiency Integrated Mid Infrared to Visible Up-conversion System
Authors: Motmaen Aytak , Rostami Ali , Matloub Samiye 
Published: June 2020

AbstractIn this paper, we have introduced and investigated an integrated optoelectronic chip for the up-conversion of mid-infrared to visible light. A thin layer of the nanocrystalline photoconductive PbSe is put on the Base of the NPN bipolar junction transistor and a doped phosphorescence organic light-emitting diode is placed on the Collector contacts. The incoming mid-infrared light is converted into an electric current by quantum dot photodetector, then amplified by the NPN bipolar junction transistor, and finally, the amplified current is driven through the Collector in the organic light-emitting diode. The organic light-emitting diode is designed to emit a green color. Our findings indicated that the proposed devices provide an up-conversion process from mid-infrared to visible light with a high-efficiency rate. The quantum dot photodetector is designed to detect 3 μm and also the organic light-emitting diode works at 523 nm. It is easy to tune the 3 ~ 5 μm incoming light by tuning the PbSe quantum dots, and the output light is tuned by tuning the organic light-emitting diode structure. Thus, the proposed structure is highly flexible regarding receiving mid-infrared and generating visible light. It is concluded that the external quantum efficiency for the proposed structure for 3 μm to 523 nm is 600. Also, the enhancement of the transistor current gain (β) can further increase the conversion efficiency of the proposed device. Moreover, different structures such as Darlington can be used instead of the bipolar junction transistor to enhance conversion efficiency.
Functional Infrared Thermal Imaging: A Contemporary Tool in Soft Tissue Screening
Authors: Ioannou Stephanos 
Published: June 2020

AbstractSoft tissue injury screening faces two main diagnostic challenges. One is the perceptual bias of the athlete in terms of referred pain and second injury assessment tools are not only in need of highly specialized personal but they are also financially demanding. Since ankle sprains is one of the leading soft tissue injuries, the current study was set to examine the suitability of functional infrared thermal imaging (fITI) in evaluating physiological alteration on the ankle as a result of exercise or injury. The current study consists of a case report of a patient with an ankle sprain and the behavior of temperature after a series of physiotherapy sessions. Moreover to strengthen the communication of the report, results from a healthy population sample were added to draw a deeper understanding on physiological temperature manifestations on soft tissue. Twenty participants underwent a 30-minute treadmill run with pictures of their ankles being taken during rest and after exercise. In addition the case of a patient is reported that has suffered an ankle sprain followed for a period of over a month. It was observed that the temperature of the ankles of participants that underwent physical exercise rose on average by 2.4 °C after taking into account both the medial and lateral sides of the both ankles. In addition the patient’s left ankle appeared to be 2.5 °C above the temperature of the non-affected right ankle. This phenomenon of unilateral hyperthermia of the left injured side seems to start to dissipate by the 21stday following the injury, completely resolving by the 42ndday achieving bilateral isothermia in both ankles. Thermal imaging provides a reliable tool for the screening of soft tissue strain and injury. The current study further expands the literature on soft tissue screening with the use of thermal imaging, adding a quantifiable way for assessing the extend of tissue damage. The implemented method of analyses offers a suggested simple way not only in visualizing trauma but also physical strain. Nevertheless further investigations with a variety in the severity of ankle sprains need to be applied in order for thermal imaging to be used as a first line tool for the assessment and recovery of ankle sprains.
The PPAR α/γ Agonist Saroglitazar Improves Insulin Resistance and Steatohepatitis in a Diet Induced Animal Model of Nonalcoholic Fatty Liver Disease
Authors: Kumar Divya P. , Caffrey Rebecca , Marioneaux Jonathon , Santhekadur Prasanna K. , Bhat Madhavi , Alonso Cristina , Koduru Srinivas V. , Philip Binu , Jain Mukul R. , Giri Suresh R. , Bedossa Pierre , Sanyal Arun J. 
Published: June 2020

AbstractInsulin resistance and hepatic lipid accumulation constitute the metabolic underpinning of nonalcoholic steatohepatitis (NASH). We tested the hypothesis that saroglitazar, a PPAR α/γ agonist would improve NASH in the diet-induced animal model of NAFLD. Mice received chow diet and normal water (CDNW) or high fat western diet and ad lib sugar water (WDSW). After 12 weeks, WDSW fed mice were randomized to receive (1) WDSW alone, (2) WDSW + vehicle, (3) WDSW + pioglitazone or (4) WDSW + saroglitazar for an additional 12 weeks. Compared to mice on WDSW and vehicle controls, mice receiving WDSW + saroglitazar had lower weight, lower HOMA-IR, triglycerides, total cholesterol, and ALT. Saroglitazar improved steatosis, lobular inflammation, hepatocellular ballooning and fibrosis stage. NASH resolved in all mice receiving saroglitazar. These effects were at par with or superior to pioglitazone. Molecular analyses confirmed target engagement and reduced oxidative stress, unfolded protein response and fibrogenic signaling. Transcriptomic analysis further confirmed increased PPAR-target expression and an anti-inflammatory effect with saroglitazar. Lipidomic analyses demonstrated that saroglitazar also reduced triglycerides, diglycerides, sphingomyelins and ceramides. These preclinical data provide a strong rationale for developing saroglitazar for the treatment of NASH in humans.