bluuebunny/crossref_metadata_2025_split huggingface dataset:
The art of life and death: 14 year follow-up analyses of associations between arts engagement and mortality in the English Longitudinal Study of Ageing
Authors: Fancourt Daisy , Steptoe Andrew 
Published: December 2019

AbstractObjectiveTo explore associations between different frequencies of arts engagement and mortality over a 14 year follow-up period.DesignProspective cohort study.ParticipantsEnglish Longitudinal Study of Ageing cohort of 6710 community dwelling adults aged 50 years and older (53.6% women, average age 65.9 years, standard deviation 9.4) who provided baseline data in 2004-05.InterventionSelf reported receptive arts engagement (going to museums, art galleries, exhibitions, the theatre, concerts, or the opera).MeasurementMortality measured through data linkage to the National Health Service central register.ResultsPeople who engaged with receptive arts activities on an infrequent basis (once or twice a year) had a 14% lower risk of dying at any point during the follow-up (809/3042 deaths, hazard ratio 0.86, 95% confidence interval 0.77 to 0.96) compared with those who never engaged (837/1762 deaths). People who engaged with receptive arts activities on a frequent basis (every few months or more) had a 31% lower risk of dying (355/1906 deaths, 0.69, 0.59 to 0.80), independent of demographic, socioeconomic, health related, behavioural, and social factors. Results were robust to a range of sensitivity analyses with no evidence of moderation by sex, socioeconomic status, or social factors. This study was observational and so causality cannot be assumed.ConclusionsReceptive arts engagement could have a protective association with longevity in older adults. This association might be partly explained by differences in cognition, mental health, and physical activity among those who do and do not engage in the arts, but remains even when the model is adjusted for these factors.
Cross-sectional study on patient-physician aggression in Belgium: physician characteristics and aggression types
Authors: De Jager Lennart , Deneyer Michel , Buyl Ronald , Roelandt Sophie , Pacqueu Ralph , Devroey Dirk 
Published: December 2019

ObjectivesThe aim of this Belgian research study was to describe the characteristics of physicians who are at increased risk for patient-physician aggression. Second, aggression subtypes were described and data were provided on the prevalence of patient-physician aggression in Belgium.DesignCross-sectional survey.SettingPrimary and secondary care inside and outside hospitals.ParticipantsAny physician who had worked in Belgium for the preceding 12 months was eligible to participate (n=34 648).Main outcome measuresAn online, original questionnaire was used to obtain physician characteristics (eg, age, sex, native language), department, working conditions and contact with aggressive patients during their career and during the preceding 12 months.ResultsThe questionnaire was completed by 4930 participants and 3726 (76%) were valid to take into account for statistics. During the preceding 12 months, 37% had been victims of aggression: 33% experienced verbal aggression, 30% psychological, 14% physical and 10% sexual. Multiple answers were allowed. Women and younger physicians were more likely to experience aggression. Psychiatric departments and emergency departments were the settings most commonly associated with aggression. Physicians who provided primarily outpatient care were more subject to aggression.ConclusionBelgian physicians experience several forms of aggression. Those most at-risk of aggression are young and female physicians who work in outpatient, emergency or psychiatric settings.
Exploring the psychometric properties of the Rainbow Model of Integrated Care measurement tool for care providers in Australia
Authors: Fares Julian , Chung Kon Shing Kenneth , Passey Megan , Longman Jo , Valentijn Pim P 
Published: December 2019

ObjectiveTo assess the reliability and validity of a shortened version of the Rainbow Model of Integrated Care (RMIC) measurement tool (MT). The original version of the measurement tool has been modified (shortened) for the Australian context.DesignValidation of the psychometric properties of the RMIC-MT.SettingHealthcare providers providing services to a geographically defined rural area in New South Wales (NSW), Australia.ParticipantsA sample of 56 healthcare providers providing mental and physical healthcare.Main outcome measuresThe psychometric properties of the tool were tested using principal component analysis for validity and Cronbach’s alpha for reliability.ResultsThe tool was shown to have good validity and reliability. The 35 items used in the shortened version of the tool were reduced to 29 items grouped into four dimensions: community-governance orientation, normative integration, functional integration and clinical-professional coordination.ConclusionsThe shortened version of the RMIC-MT is a valid and reliable tool that evaluates integrated care from a healthcare provider’s perspective in NSW, Australia. In order to assess the tool’s appropriateness in an international context, future studies should focus on validating the tool in other healthcare settings.
Supporting survivors of sexual violence: protocol for a mixed-methods, co-research study of the role, funding and commissioning of specialist services provided by the voluntary sector in England
Authors: Combes Gill , Damery Sarah , Gunby Clare , Harlock Jenny , Isham Louise , Jones Alice , Maxted Fay , Parmar Priti , Schaub Jason , Smith Deb , Taylor Julie , Bradbury-Jones Caroline 
Published: December 2019

IntroductionThe voluntary sector provides a range of specialist services to survivors of sexual violence, many of which have evolved from grass roots organisations responding to unmet local needs. However, the evidence base is poor in terms of what services are provided to which groups of survivors, how voluntary sector specialist (VSS) services are organised and delivered and how they are commissioned. This will be the first national study on the role of the voluntary sector in supporting survivors in England.Methods and analysisThis study uses an explanatory sequential naturalistic mixed-methods design with two stages. For stage 1, two national surveys of providers’ and commissioners’ views on designing and delivering VSS services will facilitate detailed mapping of service provision and commissioning in order to create a taxonomy of VSS services. Variations in the national picture will then be explored in stage 2 through four in-depth, qualitative case studies using the critical incident technique to explain the observed variations and understand the key contextual factors which influence service provision. Drawing on theory about the distinctive service contribution of the voluntary sector, survivors will be involved as co-researchers and will play a central role in data collection and interpretation.Ethics and disseminationEthical approval has been granted by the University of Birmingham research ethics committee for stage 1 of the project. In line with the sequential and co-produced study design, further applications for ethical review will be made in due course. Dissemination activities will include case study and end-of-project workshops; good practice guides; a policy briefing; project report; bitesize findings; webinars; academic articles and conference presentations. The project will generate evidence about what survivors want from and value about services and new understanding about how VSS services should be commissioned and provided to support survivors to thrive in the long term.
Association between procedure appropriateness and patient-reported outcomes after percutaneous coronary intervention
Authors: Yang Jesse Xiaolong , Stevenson Margaret J , Valsdottir Linda , Ho Kalon , Spertus John A , Yeh Robert W , Strom Jordan B 
Published: December 2019

ObjectiveThe Appropriate Use Criteria (AUC) has been used to identify individuals who are likely to benefit from percutaneous coronary intervention (PCI) for stable ischaemic heart disease. However, whether physicians reliably grade PCI appropriateness and whether AUC categories stratify symptomatic improvement in real-world practice are unclear.MethodsPatient-reported outcomes measures (PROMs) for angina (Seattle Angina Questionnaire (SAQ-7)), dyspnoea (Rose Dyspnea Scale (RDS)) and depression (Patient Health Questionnaire-2 (PHQ-2)) were collected on patients undergoing elective coronary angiography at an academic medical centre. Retrospectively, two physicians independently determined PCI appropriateness by the AUC criteria.ResultsInter-rater agreement on appropriateness was moderate (κ=0.48, 95% CI 0.32 to 0.63). Of PCI procedures evaluated, 57 (47.1%) were appropriate (A-PCI), 62 (51.2%) were maybe appropriate (MA-PCI) and 2 (1.6%) were rarely appropriate. At baseline, A-PCI compared with MA-PCI patients had worse RDS scores (2.0 vs 1.2, p=0.01). At 30 days, the change in SAQ-7 summary score was similar between groups (A-PCI vs MA-PCI, +27.1 vs +20.7, p=0.11). The mean change in RDS score was greater in A-PCI than MA-PCI (−1.0 vs −0.5, p for group by time interaction=0.03). PHQ-2 scores were similar and did not improve at 30 days.ConclusionIn patients undergoing PCI with PROMs collected before and 30 days after PCI, similar improvements in angina were observed regardless of appropriateness. Inter-rater agreement on PCI appropriateness was only moderate. Use of PROMs may improve reliability of physician assessments of PCI appropriateness.
Environmental and field characteristics associated with lameness in sheep: a study using a smartphone lameness app for data recording
Authors: Vittis Yiorgos , Kaler Jasmeet 
Published: December 2019

BackgroundSheep lameness is a major concern among farmers and policymakers with significant impacts on animal welfare standards as well as financial and production performance. The present study attempts to identify the relative importance of environmental and farm‐level management characteristics on sheep lameness.MethodTo address this objective, data were derived from the SPiLaMM project from 18 farms that used smartphone app to collect data, the British Geological Survey and the Meteorological Office over 2016–2018. Data were analysed using a multilevel Poisson regression model.ResultsTemperature and higher length of pasture had a positive relationship with lameness while concentration of Selenium in soil and flock size had a negative relationship with lameness. In addition, results showed lower lameness levels for the bedrock class mudstone, siltstone, limestone and sandstone in comparison to sandstone and finally, lambs and ewes younger than 1year old had lower levels of lameness than older ewes.ConclusionFindings of the present approach show the potential use of data collected via a smartphone app to study the epidemiology of disease. Furthermore, factors identified could be validated in intervention studies and generate data‐driven disease predictive models.
Quasinormal modes of dilatonic Reissner–Nordström black holes
Authors: Blázquez-Salcedo Jose Luis , Kahlen Sarah , Kunz Jutta 
Published: December 2019

AbstractWe calculate the quasinormal modes of static spherically symmetric dilatonic Reissner–Nordström black holes for general values of the electric charge and of the dilaton coupling constant. The spectrum of quasinormal modes is composed of five families of modes: polar and axial gravitational-led modes, polar and axial electromagnetic-led modes, and polar scalar-led modes. We make a quantitative analysis of the spectrum, revealing its dependence on the electric charge and on the dilaton coupling constant. For large electric charge and large dilaton coupling, strong deviations from the Reissner–Nordström modes arise. In particular, isospectrality is strongly broken, both for the electromagnetic-led and the gravitational-led modes, for large values of the charge.
Structural and magnetic properties of high magnetic-field-assisted hydrothermal synthesized Bi6Fe2Ti3O18 particles
Authors: Liu Shengman 
Published: December 2019

[Formula: see text] (BFTO) nanoparticles were successfully synthesized by hydrothermal method in high magnetic fields of 0T, 2T, 4T, and 8T. High magnetic field can greatly affect the growth behavior of BFTO particles. The magnetic fields promote the BFTO nanoplates to grow along (001) direction and form a high-index {115} facet. The BFTO samples prepared in different magnetic fields are paramagnetic with the presence of an antiferromagnetic (AFM) and ferromagnetic ordering, and the AFM interaction weakens when the magnetic field is increased. In particular, the magnetization of the as-prepared BFTO particles is slightly enhanced with the increase in magnetic fields arising from the increased amount of bipyramid particles in favor of [Formula: see text]–[Formula: see text] plane alignment parallel to the magnetic field.
A workflow for the rapid assessment of the landslide-tsunami hazard in peri-alpine lakes
Authors: Strupler Michael , Anselmetti Flavio S. , Hilbe Michael , Kremer Katrina , Wiemer Stefan 
Published: December 2019

Abstract
Although lake tsunamis constitute a rare peril, they have repeatedly occurred in peri-alpine lakes in the past. There are several documented historical examples of landslide-triggered tsunamis in Swiss lakes. However, fundamental information and workflows to rapidly quantify the lacustrine tsunami hazard for multiple lakes are missing so far. The fact that the shorelines of major peri-alpine lakes are densely populated underlines the need for a hazard assessment. Detailed assessments require high-resolution geophysical, geotechnical and sedimentological data, and considerable computation time. Due to the involved data acquisition and calculation efforts, such assessments are mainly conducted as detailed case studies for single lakes. We present a workflow for a rapid first-order estimation of the landslide-triggered tsunami hazard along the shores of peri-alpine lakes. A crucial step is the identification of potential tsunami sources. Unstable slopes are mapped automatically, based on parameters that are derived from past studies. Such parameters include the bathymetry and derived parameters, and type, characteristics and thickness of the sediments. Wave amplitudes are estimated with existing predictive equations, based on the constructed maps of potentially unstable slopes. The results may be used for focusing more detailed, lake-specific tsunami-hazard assessments in respective areas.
Structural constraints on the subduction of mass-transport deposits in convergent margins
Authors: Geersen Jacob , Festa Andrea , Remitti Francesca 
Published: December 2019

Abstract
The subduction of large and heterogeneous mass-transport deposits (MTDs) is discussed to modify the structure and physical state of the plate boundary and therewith exert an influence on seismicity in convergent margins. Understanding which subduction-zone architectures and structural boundary conditions favour the subduction of MTDs, primarily deposited in oceanic trenches, is therefore highly significant. We use bathymetric and seismic reflection data from modern convergent margins to show that a large landslide volume and long runout, in concert with thin trench sediments, increase the chances for an MTD to become subducted. In regions where the plate boundary develops within the upper plate or at its base (non-accretionary margins), and in little-sedimented trenches (sediment thickness <2 km), an MTD has the highest potential to become subducted, particularly when characterized by a long runout. On the contrary, in the case of a heavily sedimented trench (sediment thickness >4 km) and short runout, an MTD will only be subducted if the thickness of subducting sediments is higher than the thickness of sediments under the MTD. The results allow identification of convergent margins where MTDs are preferentially subducted and thus potentially alter plate-boundary seismicity.
Performance Analysis of Workload Dependent Load Balancing Policies
Authors: Hellemans Tim , Bodas Tejas , Van Houdt Benny 
Published: December 2019

Load balancing plays a crucial role in achieving low latency in large distributed systems. Recent load balancing strategies often rely on replication or use placeholders to further improve latency. However assessing the performance and stability of these strategies is challenging and is therefore mostly simulation based. In this paper we introduce a unified approach to analyze the performance and stability of a broad class of workload dependent load balancing strategies. This class includes many replication policies, such as replicate below threshold, delayed replication and replicate only small jobs, as well as strategies for fork-join systems.
We consider systems with general job size distributions where jobs may experience server slowdown. We show that the equilibrium workload distribution of the cavity process satisfies a functional differential equation (FDE) and conjecture that the cavity process captures the limiting behavior of the system as its size tends to infinity. The cavity process method assumes that the workload at the queues is independent and identically distributed. This way, one may focus on the behaviour of one queue, this method was introduced in [1] and is shown to yield exact results for SQ(d) with job size distribution that have a decreasing hazard rate and LL(d) with general job sizes.
App in the Middle
Authors: Zhang Lei , Yang Zhemin , He Yuyu , Li Mingqi , Yang Sen , Yang Min , Zhang Yuan , Qian Zhiyun 
Published: December 2019

Customizability is a key feature of the Android operating system that differentiates it from Apple's iOS. One concrete feature that gaining popularity is called "app virtualization". This feature allows multiple copies of the same app to be installed and opened simultaneously (e.g., with multiple accounts logged in). Virtualization frameworks are used by more than 100 million users worldwide. As with any new system features, we are interested in two aspects: (1) whether the feature itself introduces security risks and (2) whether the feature is abused for unintended purposes. This paper conducts a systematic study on the two aspects of the app virtualization techniques.
With a thorough study of 32 popular virtualization frameworks from Google Play, we identify seven areas of potential attack vectors and find that most of the frameworks are susceptible to them. By deeply investigating their ecosystem, we show, with demonstrations, that attackers can easily distribute malware that takes advantage of these attack vectors. In addition, we show that the same virtualization techniques are also abused by malware as an alternative and easy-to-use repackaging mechanism. To this end, we design and implement a new app repackage detector. After scanning 250,145 apps from app markets, it finds 164 repackaged apps that attempt to steal user credentials and private data.
A simple linear readout of MT supports motion direction-discrimination performance
Authors: Yates Jacob L. , Katz Leor N. , Levi Aaron J. , Pillow Jonathan W. , Huk Alexander C. 
Published: December 2019

Motion discrimination is a well-established model system for investigating how sensory signals are used to form perceptual decisions. Classic studies relating single-neuron activity in the middle temporal area (MT) to perceptual decisions have suggested that a simple linear readout could underlie motion discrimination behavior. A theoretically optimal readout, in contrast, would take into account the correlations between neurons and the sensitivity of individual neurons at each time point. However, it remains unknown how sophisticated the readout needs to be to support actual motion-discrimination behavior or to approach optimal performance. In this study, we evaluated the performance of various neurally plausible decoders, trained to discriminate motion direction from small ensembles of simultaneously recorded MT neurons. We found that decoding the stimulus without knowledge of the interneuronal correlations was sufficient to match an optimal (correlation aware) decoder. Additionally, a decoder could match the psychophysical performance of the animals with flat integration of up to half the stimulus and inherited temporal dynamics from the time-varying MT responses. These results demonstrate that simple, linear decoders operating on small ensembles of neurons can match both psychophysical performance and optimal sensitivity without taking correlations into account and that such simple read-out mechanisms can exhibit complex temporal properties inherited from the sensory dynamics themselves. NEW & NOTEWORTHY Motion perception depends on the ability to decode the activity of neurons in the middle temporal area. Theoretically optimal decoding requires knowledge of the sensitivity of neurons and interneuronal correlations. We report that a simple correlation-blind decoder performs as well as the optimal decoder for coarse motion discrimination. Additionally, the decoder could match the psychophysical performance with moderate temporal integration and dynamics inherited from sensory responses.
Comparative gain-of-function effects of the KCNMA1-N999S mutation on human BK channel properties
Authors: Moldenhauer Hans J. , Matychak Katia K. , Meredith Andrea L. 
Published: December 2019

KCNMA1, encoding the voltage- and calcium-activated potassium channel, has a pivotal role in brain physiology. Mutations in KCNMA1 are associated with epilepsy and/or dyskinesia (PNKD3). Two KCNMA1 mutations correlated with these phenotypes, D434G and N999S, were previously identified as producing gain-of-function (GOF) effects on BK channel activity. Three new patients have been reported harboring N999S, one carrying a second mutation, R1128W, but the effects of these mutations have not yet been reported under physiological K+ conditions or compared to D434G. In this study, we characterize N999S, the novel N999S/R1128W double mutation, and D434G in a brain BK channel splice variant, comparing the effects on BK current properties under a physiological K+ gradient with action potential voltage commands. N999S, N999S/R1128W, and D434G cDNAs were expressed in HEK293T cells and characterized by patch-clamp electrophysiology. N999S BK currents were shifted to negative potentials, with faster activation and slower deactivation compared with wild type (WT) and D434G. The double mutation N999S/R1128W did not show any additional changes in current properties compared with N999S alone. The antiepileptic drug acetazolamide was assessed for its ability to directly modulate WT and N999S channels. Neither the WT nor N999S channels were sensitive to the antiepileptic drug acetazolamide, but both were sensitive to the inhibitor paxilline. We conclude that N999S is a strong GOF mutation that surpasses the D434G phenotype, without mitigation by R1128W. Acetazolamide has no direct modulatory action on either WT or N999S channels, indicating that its use may not be contraindicated in patients harboring GOF KCNMA1 mutations. NEW & NOTEWORTHY KCNMA1-linked channelopathy is a new neurological disorder characterized by mutations in the BK voltage- and calcium-activated potassium channel. The epilepsy- and dyskinesia-associated gain-of-function mutations N999S and D434G comprise the largest number of patients in the cohort. This study provides the first direct comparison between D434G and N999S BK channel properties as well as a novel double mutation, N999S/R1128W, from another patient, defining the functional effects during an action potential stimulus.