bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peran Pendidikan dalam Merubah Karakter Masyarakat Dampak Akulturasi Budaya di Temajuk
Authors: Aslan Aslan , Setiawan Agus , Hifza Hifza 
Published: July 2020

Guru adalah aktor dalam dunia pendidikan dan manuskrip cerita adalah kurikulumnya. Tanpa guru maka dunia pendidikan akan mengalami masalah yang begitu besar. Penelitian ini merupakan penelitian lapangan. Hasil temuan penelitian ini adalah: perkembangan teknologi membuat kewajiban seorang guru semakin besar, karena jika peran guru hanya sebatas mengajar, maka anak didik hanya ahli dalam intelektual tetapi tidak mempunyai adab dan sopan santun. Begitu juga sebaliknya, jika peran guru tidak hanya mengajar tetapi memberikan nilai keteladanan baik di sekolah maupun luar lingkungan sekolah, maka bukan hanya menghasilkan intelektual tetapi juga menghasilkan adab dan sopan santun. Oleh karena itu, peran kurikulum dalam lembaga pendidikan sangat penting terlebih pada pendidikan Islam, sehingga tidak hanya sebagai rangkaian dari proses belajar mengajar, akan tetapi nilai-nilai dari kurikulum tersebut merupakan filosofi dari tujuan pendidikan membentuk nilai-nilai karakter siswa.
A Simple and Rapid System for Proteomic Analysis of the Archaeon Candidatus Vulcanisaeta moutnovskia
Authors: Chernyh Nikolay A. , Neukirchen Sinje , Frolov Evgenii N. , Sousa Filipa L. , Miroshnichenko Margarita L. , Merkel Alexander Y. , Pimenov Nikolay V. , Sorokin Dimitry Y. , Ciordia Sergio , Mena María C. , Ferrer Manuel , Golyshin Peter N. , Lebedinsky Alexander V. , Pereira Inês A. Cardoso , Bonch-Osmolovskaya Elizaveta A. 
Published: July 2020

Abstract
This protocol describes a rapid protein extraction method for the archaeon Candidatus Vulcanisaeta moutnovskia, which can be also implemented for other archaea. The utilization of two different methods for protein extraction constitute the main step of the protocol. Method I involves the extraction with a multi-chaotropic lysis buffer containing a non-denaturing zwitterionic detergent, most efficient for extracting cytosolic proteins. Method II involves a denaturing anionic detergent allowing total disruption of the membranes and capable of extracting both membrane (hydrophobic) and non-membrane (water-soluble, hydrophilic) proteins. The big advantage of the methods is to use general laboratory chemicals to make powerful extraction buffers, resulting in high quality and quantity of proteins. The methods probably are usable for any other archaea or microbial cells, and takes about 14-22 h. Following extraction and further protein digestion, 1D-nano Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometric (LC ESI-MSMS) analysis with Triple TOF 5600 and Orbitrap technologies were used for protein identification and further quantification.
Cattle-Related Trauma: A 5 Year Retrospective Review In A Adult Major Trauma Centre
Authors: Rhind John-henry , Quinn Dominic , Cosbey Lucy , Mobley Douglas , Britton Ingrid , Lim Justin 
Published: July 2020

Abstract
Background:Bovine injuries are a common and significant cause of trauma, often requiring admission and operative treatment. We review all bovine related injuries over five years, both emergency and GP referrals at an adult major trauma centre in England.Method:Retrospective evaluation was undertaken using keywords through radiology referrals and hospital admissions speciality databases. By searching patient notes, demographics were collected as well as the mechanism and the situation of injury; trauma scores were calculated using: Injury Severity Score (ISS) and Probability of Survival (Ps19). Results were divided into emergency patients and GP referrals.Results:Sixty-seven patients were identified retrospectively over 5 years, 44 emergency patients (including 23 major traumas) and 23 GP referrals. Combined (Emergency & GP) mean age 52 years old. 67% male. Mean ISS 11. Most common combined mechanism of injury, kicked (n=23). In emergency patients, trampling injuries were most common. 86% of the trampled patients were major traumas and associated with increased ISS (mean 13). Indirect injuries mainly involved farm gates (92%). 73% of bull-related injuries were major traumas and had increased ISS scores (mean 17). Orthopaedics was the most common admitting speciality followed by cardiothoracic & neurosurgery. In emergency patients fractures were the most common primary injury (n=20), upper limb followed by spine. In GP, soft tissue injuries were the most common primary injury. 70% of the emergency referrals required admission and 50% operations. Fracture fixation was the most common operative procedure. Only one GP referral required an operation. There were significant delays in GP patients presenting. Two patients had a Ps19 score <90. There were two mortalities.Conclusion:Cattle related injuries are a significant cause of severe morbidity and mortality. They are under-reported. Patterns of injury are similar to high velocity road traffic collisions and bull-related injuries or trampling in particular, should alert the clinician to more significant trauma. Farm gates are a frequent cause of trauma associated with cattle. GP referrals with ongoing symptoms for more than two weeks seeking medical advice should alert the clinician to a more serious diagnosis.
Free cortisol/cortisone ratio in morning urine as a biomarker of health status in older Japanese adults
Authors: Mutsamoto Akiko , Shimanoe Chisato , Hara Megumi , Akao Chiho , Nishida Yuichiro , Ichiba Masayoshi , Tanaka Keitaro 
Published: July 2020

Abstract
Secretion of cortisol in humans peaks in the morning, reflecting robust circadian rhythms, which are essential for homeostasis. To examine the hypothesis that free cortisol levels in the morning can predict general health status, free cortisol and cortisone in urine samples collected from 7813 Japanese older adults upon waking were measured by liquid chromatography-mass spectrometry (LCMS). The ratio of cortisol to cortisone in 5298 urine collected between 6 and 11 AM showed consistent correlations with favorable personal attributes linking to good health. The odds ratio of poor health, as defined by multiple clinical criteria (BMI ≥25, SBP ≥140 mmHg, C-reactive protein ≥0.5 mg/dL, and HbA1c ≥5.6%) or cardio-cerebro-vascular disease history, robustly showed negative associations with the cortisol/cortisone ratio. The free cortisol/cortisone ratio in urine samples collected upon waking is a promising biomarker of good health and might be applicable to a wide range of research and medical settings.
Nose-only inhalation exposures to alumina nanoparticles / hydrogen chloride gas mixtures induce strong pulmonary pro-inflammatory response
Authors: Bourgois Alexandra , Saurat Dominique , Boyard Alexandre , Guitard Nathalie , Araujo Suzanne De , Renault Sylvie , Fargeau Francisca , Frédéric Christine , Peyret Emmanuel , Flahaut Emmanuel , Servonnet Aurélie , Favier Anne-Laure , Lacroix Ghislaine , François Sabine , Dekali Samir 
Published: July 2020

Abstract
Background: Combustion processes, especially in aerospace and defense fields, can lead to complex aerosols emission containing gases and nanoparticles (NPs). Alumina (Al2O3) NPs and hydrogen chloride gas (HClg) are for instance present in high concentrations after solid composite propellants use. Exposure to these pollutants mixtures by inhalation is thus possible but literature data towards their pulmonary toxicity are missing. To specify hazards resulting from these combustion aerosols, an inhalation study was implemented.Male Wistar rats were exposed by nose-only to Al2O3 NPs (13 nm) and/or HClg aerosols for 4h (unique exposures ; UE) or 4h a day for 4 days (iterative exposures ; IE). Bronchoalveolar lavage fluids (BALF) content and lungs histopathology were analyzed 24h after exposures.Results: Iterative co-exposures (IE) increased total proteins and lactate dehydrogenases (LDH) concentrations in BALF indicating alveolar-capillary barrier permeabilization and cytolysis. Early pulmonary inflammation was induced after IE to Al2O3 NPs ± HClg resulting in polymorphonuclear neutrophils (PMN) and pro-inflammatory cytokines increases (TNF-α, IL-1β, GRO/KC) in BALF. Moreover, after exposure to Al2O3 NPs ± HClg aerosols, both exposure scenarios induced early pulmonary histopathological lesions, among which vascular congestions, bronchial pre-exfoliations, vascular and interalveolar septum edemas. Lung oxidative damages (8-hydroxy-2'-deoxyguanosine ; 8-OHdG) were observed in situ following UE in each experimental condition, suggesting early oxidative stress induction by aerosols inhalation. However, no 8-isoprostane concentration increase was simultaneously found in animals BALF.Conclusions: Biological effects of the studied aerosols are dependent on both aerosol content and exposure scenario. Results showed an important early pro-inflammatory effect of Al2O3 NPs/HClg mixtures on rats lungs following iterative inhalations (IE). Taken together these data raise concerns towards potential long term pulmonary toxicity of combustion mixtures aerosols, and highlight the importance for workers to wear individual protections.
Status of Vaccine Coverage In Venezuelan Children, A Country With A Complex Humanitarian Crisis
Authors: Drummond Tatiana , Marín Isabel , Sánchez Anny , Reyes Marianjosé , García Jenny , Torrealba Rosa , Stanchieri Mariana , Rodríguez Benny , Troncone Ángela 
Published: July 2020

Abstract
In Venezuela, PAHO has reported an increase in vaccine-preventable diseases since 2016. The goal of this work was to assess vaccination coverage in children hospitalized in the Department of Pediatrics at the Hospital Universitario de Caracas (HUC). Methods: A descriptive cross-sectional study included 0 to 12 years old children hospitalized in HUC admitted between January 2015 and December 2019, and verified immunization scheme. The patient data were compared with the schedule of the Ministry of Health of Venezuela and analyzed by comparing immunization coverage by year of patient hospitalization and patient age. Results: A total of 2903 patients were surveyed, corresponding to 53.2% male, 37.4% infants. A coverage level above 95% was found only for BCG. Comparing vaccination coverage with the vaccination schedule vs year of patient hospitalization, it was observed a mean decrease in vaccine coverage of 21.5% in 2019 relative to 2015 (p = 0.0000). Vaccination rates in children under one year old were lower than in children older than 6 years for all vaccines (p = 0.0000) Conclusions: There is a decline in vaccination coverage in 2019 in relation to previous years, being the most affected children less than one year old
Ethnobotanical Study of Fumaria Indica Plant From the Hilly and Plain Areas of Haripur
Authors: Shaeen Lubna , Shah Gulam Mujtaba , Rehman Nadia , bibi saira , khan fiaz , Ahmad Waseem , Khan Shah Masaud 
Published: July 2020

Abstract
BackgroundThe purpose of this study was to find out the ethnobotanical use of Fumaria indica plant from the hilly and plain areas of Haripur .MethodsThe plant samples of leaf, flowers and root were collected from two hilly areas (Srikot, Khanpur) and two plane areas (Haripur city, Tarbela) of District Haripur and processed for further analysis process. The preferences of local people for the treatment of various ailments in terms of medicinal plant used, part used, the category of diseases treated and the form of therapeutic use (recipe) were analyzed with the help of a questionnaire survey. The recorded data was tabulated theme wise and Microsoft Excel program was used in the calculation of values and percent references and its presentation in graphic form.ResultsEthnobotanical study showed that the Fumaria indica plant used as a source of medicine in local community, the powder form was used in allergies, fevers and diabetes. The plant was used as a source of medicine and cure many types of bacteria diseases.conclusionFumaria indica & Caesalpinia bonducella are the plants known for their digestive, spasmolytic, diuretic, anthelmintic, hepatoprotective, anti-inflammatory, antipyretic anti dysentery activity.Powder drugs of (leaves, roots and flowers) of Fumaria indica were made for different analyses.
PGRN alleviates cerebral amyloid-β burden and cognitive impairments via mediating neuroinflammation
Authors: Xu Wei , Tan Chen-Chen , Cao Xi-Peng , Yu Jin-Tai , Tan Lan 
Published: July 2020

Abstract
Background

Both progranulin (PGRN) and neuroinflammatory activities increased over the course of Alzheimer’s disease (AD). In this study, we set out to determine if cerebrospinal fluid (CSF) PGRN could be a marker of neuroinflammation, and if so, how it contributed to AD pathogenesis and cognitive impairments.
Methods

A total of 965 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) were grouped within the framework of A-T-N biomarker profile and clinical stage. Causal mediation analyses with 10,000 bootstrapped iterations were conducted to explore the mediation effects of neuroinflammatory markers on the associations of PGRN with amyloid burden indicated by CSF β-amyloid (Aβ) levels. The longitudinal influences of PGRN on cognition were tested.
Results

CSF PGRN and multiple neuroinflammatory markers (sTNFR1, sTNFR2, TGF-β1, VCAM1, and ICAM1) were increased with tau-related neurodegeneration. PGRN was positively linked with neuroinflammatory markers associated with tau pathologies (TN+). In TN + population, PGRN was associated with higher CSF Aβ42 via mediating neuroinflammatory markers and could predict slower cognitive decline. The abovementioned associations became non-significant in TN- profile.
Conclusions

These preliminary findings supported that PGRN could protect against Aβ pathology and cognitive impairments via modulating neuroinflammation that occurs with neuronal injuries.
Cockroach exposure and childhood asthma: Is the effect an artifact of confounding by stress?
Authors: Rabito Felicia , Werthmann Derek , He Hua , Madkour Aubrey S. , Arroyave Whitney D. , Sever Michelle L , LaVeist Thomas A. 
Published: July 2020

Abstract
Background

Nonpharmacologic interventions for asthma management rely on identification and mitigation of important asthma triggers. Cockroach exposure is strongly associated with asthma morbidity. It is also associated with stress, another risk factor for asthma. Despite high prevalence of both in vulnerable populations, the impact of joint exposure has not been examined.
Methods

Participants included 173 children with asthma in New Orleans, Louisiana. Cockroach exposure was based on visual inspection using standard protocols. Caregiver stress was measured using Cohen’s 4-item Perceived Stress Scale. Outcomes included unscheduled clinic or emergency department (ED) visits, hospitalization, and pulmonary function. Multivariable logistic regression was performed to assess independent effects of the exposure on the outcome and effect modification was examined in stratified analysis based on stress. Path analysis to explore the mediation effect by stress was performed using a probit link with parameters based on Bayes’ method with non-informative priors.
Results

Adjusting for stress and other covariates, cockroach exposure was associated with unscheduled clinic/ED visits (aOR = 6.2; 95% CI 1.8, 21.7). Positive associations were also found for hospitalization and FEV1 < 80%. High stress modified the relationship with unscheduled clinic/ED visits (high aOR = 7.7 95% CI 1.0, 60.2, versus normal aOR = 4.1 95% CI 0.8, 21.9). Path models identified direct and indirect effects (p = 0.05) indicating that a majority of the total effect on unscheduled clinic/ED visits is attributed directly to cockroach exposure.
Conclusion

The strong association between cockroach exposure and asthma morbidity is not due to uncontrolled confounding by stress. The combination of cockroach exposure and high stress, common in urban homes, are modifiable factors associated with poor asthma outcomes.
Influence of roughness on initial in vitro response of cells to Al2O3/Ce-TZP nanocomposite
Authors: Suárez Marta , Pérez-López Silvia , Prado Catuxa , Fernández Adolfo , Moya José Serafín , Torrecillas Ramón , Díaz Luis Antonio 
Published: July 2020

Abstract
Al2O3/Ce-TZP nanocomposite has been synthetized by a colloidal processing route and sintered in air atmosphere. The roughness surface of ATZ nanocomposite by sandblasting using materials with different particle size has been modified and its influence on the osteogenic differentiation has been performed in vitro growing a human osteoblast-like cell line, SaOs-2, and Human Adipose-derived mesenchymal stem cells (hADMSC). The non-cytotoxicity and haemocompatibility of ATZ nanocomposite has been proved. An increase in the expression of BGLAP and IBSP genes was observed on samples sandblasted with white corundum (< 90 µm) whereas SPARC gene was upregulated on samples sandblasted with SiC (90–100 µm). Alumina-ceria-stabilized zirconia nanocomposite presented in this work exhibits a high potential for application in the fabrication of dental implants due to their biological behaviour and very promising mechanical properties.
Assessment of Left Ventricular Systolic Function After Revascularization in Patients with ST Segment Elevation Myocardial Infarction by Stratified Strain Technique
Authors: Liang Yi , Chen Xinxin , Xu Liangjie , Zhou Cuicui , Fan Tingpan , Yuan Wei , zhang fen 
Published: July 2020

Abstract
Objective: Stratified strain was used to evaluate the local stratified strain and the overall longitudinal strain of the left ventricle of the affected myocardium after revascularization in patients with ST-segment elevation myocardial infarction (STEMI).Methods: 120 patients diagnosed as STEMI in the Affiliated Hospital of Jiangsu University from July 2017 to August 2018 were selected. According to the time from symptom onset to balloon dilation (S-TO-B), 120 patients were divided into group A (S-TO-B≤6h) and group B (6h<S-TO-B <12h) .The changes of left ventricular global longitudinal strain (GLS), local partial layer strain (TLSendo, TLS-mid, TLSepi) and LVEF were compared between the two groups immediately after operation, 3 hours ,24 hours and 1 week after operation. The incidence of major adverse cardiovascular events (MACE) and LVEF were followed up during hospitalization and one month after operation.Results: In group A, TLSendo, TLSmid, TLSepi and GLS increased gradually at each time after vascular opening; in group B, TLSendo, TLSmid, TLSepi and GLS decreased immediately after vascular opening 3 hours after surgery, with obvious TLSendo and gradually increased, but the increase was smaller than that in group A. TLSendo,TLSmid, TLSepi and GLS increased in all patients one week after operation, but TLSendo and TLSepi increased more significantly than TLSmid, and GLS changed less. TlSendo increase of 4.50% is the most accurate parameter to predict the significant improvement of left ventricular systolic function in patients with STEMI one month after operation, with an AUC area of 0.87, sensitivity and specificity of 80.0% and 86.0%, respectively.Conclusions: Layered strain technique can be used to evaluate the myocardial strain in patients with STEMI, and recognize the effect of S-TO-B on the prognosis of STEMI, which has important clinical application value.
Unemployment of Unskilled Labor due to COVID-19 led Restriction on Migration and Trade
Authors: Mandal Biswajit , Chaudhuri Saswati , Prasad Alaka Shree 
Published: July 2020

Abstract
To combat COVID-19 the entire world has resorted to global lockdown implying restriction on international labor migration and trade. This paper aims to check the effect of such restrictions on the unemployment of unskilled labor in the source country. In competitive general equilibrium framework with three goods and four factors restriction on migration raises unemployment for given factor intensity. The results remain same even in a slightly different structure of the economy. In case of trade restriction, however, the rise or fall in unemployment depends on both the structure of the economy and the factor intensity assumption.
Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) is Highly Associated With Mortality and Persistent Organ Dysfunction in the Critically Ill: a Cohort Study
Authors: Sathe Neha Alhad , Bhatraju Pavan K. , Mikacenic Carmen , Morrell Eric D. , Liles W. Conrad , Wurfel Mark M. 
Published: July 2020

Abstract
Background. The triggering receptor expressed on myeloid cells-1 (TREM-1) mediates fatal septic shock in murine models, but studies linking the soluble form of TREM-1 (sTREM-1) to mortality in clinical sepsis are inconclusive, and few have examined its relationship to organ dysfunction. We sought to identify associations between circulating sTREM-1 and both mortality and organ dysfunction among a broad cohort of critically ill medical, post-surgical and trauma patients. Methods. We enrolled a prospective cohort of patients who met two or more criteria for the systemic inflammatory response syndrome (SIRS) within 24 hours of intensive care unit (ICU) admission at a large academic medical center. sTREM-1 concentrations were measured at study enrollment. We used relative risk regression, adjusted for age, sex, and Charlson comorbidity index, to determine associations between sTREM-1 and the primary outcome of 28-day mortality. We also examined secondary outcomes of prevalent organ dysfunction on enrollment, and composites of persistent organ dysfunction or death at day 7. Results. Among 231 critically ill patients, non-survivors (n=19, 8%) had a higher proportion of pre-existing comorbidities, mechanical ventilation (79% vs. 44%) and shock (58% vs. 28%) compared to survivors. At study enrollment, increasing sTREM-1 was associated with a higher risk of severe acute kidney injury (AKI), shock, and acute hypoxemic respiratory failure requiring mechanical ventilation. sTREM-1 was higher among non-survivors than survivors (885 vs 336 pg/mL); each doubling of sTREM-1 concentration was associated with a 2.41-fold higher risk of 28-day mortality (95% CI 1.57, 3.72). Among 92 patients with shock on enrollment, doubling of sTREM-1 was associated with a 3.89-fold higher risk of persistent shock or death by day 7 (95% CI 1.85, 8.17). Higher sTREM-1 was also associated with a higher risk of both persistent AKI and persistent hypoxemic respiratory failure or death. Conclusions. Elevated plasma sTREM-1 is highly associated with 28-day mortality and organ dysfunction across a diverse critically ill population. These data support that early activation of the innate immune system plays a role in the development of organ dysfunction and death. Further studies should address whether modulation of the TREM-1 pathway might be beneficial in critically ill patients.