bluuebunny/crossref_metadata_2025_split huggingface dataset:
JUDAEO-CONVERSOMERCHANTS IN THE PRIVATE TRADE BETWEEN MACAO AND MANILA IN THE EARLY MODERN PERIOD
Authors: de Sousa Lúcio 
Published: October 2019

ABSTRACTThe present paper intends to contribute with new information to a reconstruction of the Sephardic presence in the Macao–Manila commercial network. For this purpose, in the first place, we intend to trace the profile of theJudaeo-conversomerchants arriving in China and the Philippines and to reconstruct the commercial networks to which they belonged during the 16thand early 17thcenturies.
Cost effectiveness of dengue vaccination following pre-vaccination serological screening in Sri Lanka
Authors: Perera Sathira , John Denny , Senanayaka Buddhika 
Published: October 2019

AbstractObjectiveThis study sets an example of an economic evaluation of a model dengue vaccination strategy for Sri Lanka, following a mandatory pre-vaccination screening strategy.MethodsA decision analytic Markov model was developed to estimate the cost-effectiveness of a predicted dengue vaccination strategy over a time horizon of 10 years. The cost effectiveness of dengue vaccination strategy for seropositive individuals was estimated in terms of incremental cost effectiveness ratio (ICER) (cost per additional quality adjusted life-year [QALY]). District-specific ICER values and the budget impact for dengue vaccine were estimated with appropriate sensitivity analyses, also taking the variability of the pre-vaccination screening test performance into consideration.ResultsThe ICER for the predicted vaccination strategy following pre-vaccination screening was 4,382 USD/QALY for Sri Lanka. There was a significant regional variation in vaccine cost effectiveness. The disaggregated regional incidence of dengue and the need to perform pre-vaccination screening affects the cost effectiveness estimates significantly, where a safer version of the vaccine has the potential to become cost saving in high incidence districts.ConclusionsThe cost effectiveness of the predicted dengue vaccination strategy following pre-vaccination screening showed a significant regional variation across the districts of Sri Lanka. District-wise disease incidence and the need for pre-vaccination screening was found to be the most significant factors affecting the cost effectiveness of the vaccine.
ORDERING RESULTS ON EXTREMES OF EXPONENTIATED LOCATION-SCALE MODELS
Authors: Das Sangita , Kayal Suchandan , Choudhuri Debajyoti 
Published: October 2019

AbstractIn this paper, we consider exponentiated location-scale model and obtain several ordering results between extreme order statistics in various senses. Under majorization type partial order-based conditions, the comparisons are established according to the usual stochastic order, hazard rate order and reversed hazard rate order. Multiple-outlier models are considered. When the number of components are equal, the results are obtained based on the ageing faster order in terms of the hazard rate and likelihood ratio orders. For unequal number of components, we develop comparisons according to the usual stochastic order, hazard rate order, and likelihood ratio order. Numerical examples are considered to illustrate the results.
A Systematic Review of the Impact of Disaster on the Mental Health of Medical Responders
Authors: Naushad Vamanjore Aboobaker , Bierens Joost JLM , Nishan Kunnummel Purayil , Firjeeth Chirakkal Paramba , Mohammad Osama Hashim , Maliyakkal Abdul Majeed , ChaliHadan Sajid , Schreiber Merritt D. 
Published: October 2019

AbstractIntroduction:Medical responders are at-risk of experiencing a wide range of negative psychological health conditions following a disaster.Aim:Published literature was reviewed on the adverse psychological health outcomes in medical responders to various disasters and mass casualties in order to: (1) assess the psychological impact of disasters on medical responders; and (2) identify the possible risk factors associated with psychological impacts on medical responders.Methods:A literature search of PubMed, Discovery Service, Science Direct, Google Scholar, and Cochrane databases for studies on the prevalence/risk factors of posttraumatic stress disorder (PTSD) and other mental disorders in medical responders of disasters and mass casualties was carried out using pre-determined keywords. Two reviewers screened the 3,545 abstracts and 28 full-length articles which were included for final review.Results:Depression and PTSD were the most studied outcomes in medical responders. Nurses reported higher levels of adverse outcomes than physicians. Lack of social support and communication, maladaptive coping, and lack of training were important risk factors for developing negative psychological outcomes across all types of disasters.Conclusions:Disasters have significant adverse effects on the mental well-being of medical responders. The prevalence rates and presumptive risk factors varied among three different types of disasters. There are certain high-risk, vulnerable groups among medical responders, as well as certain risk factors for adverse psychological outcomes. Adapting preventive measures and mitigation strategies aimed at high-risk groups would be beneficial in decreasing negative outcomes.
Fading local effects: boom and bust evidence from a Peruvian gold mine
Authors: Orihuela José Carlos , Gamarra-Echenique Victor 
Published: October 2019

AbstractThe local effects of mining might simply come and go with mine production. In this paper we revisit Aragón and Rud's (2013) study of the Yanacocha mine, frequently cited to account for local economic effects and backward linkages, but we offer a more nuanced interpretation: first, effects fade with the mine exhaustion; and second, impacts are the result of consumption boom-and-bust dynamics. While we find it more conceptually accurate to reserve the concept of backward linkages for effects of a productive nature, our evidence reveals that unskilled services is the one sector that benefits, in contrast to manufactures and skilled services. We stress that impact evaluations of mines are contingent to time and place, and contend that exploring the extent to which multipliers generate spillovers is central. The short-run effects of a mine might in fact give little indication of how to tell or make a blessing from a curse.
Carl Schmitt and the evolution of Chinese constitutional theory: Conceptual transfer and the unexpected paths of legal globalisation
Authors: BRANG LUCAS 
Published: October 2019

Abstract:The intense reception of Carl Schmitt’s writings among Chinese constitutional theorists is one of the more striking phenomena within the globalisation of constitutional thought in recent decades. This article approaches it from two angles. First, the reception of Schmitt and the subsequent debates about his oeuvre and persona are interpreted as performative practices in which Schmitt soon emerged as both the bête noire of a liberal-leaning constitutional scholarship and an object of romantic projection for avant-garde theoretical endeavours. Engagement with Schmitt thus crucially contributed to the emergence of both a neo-conservative and a critical-liberal sensibility among Chinese legal scholars. Second, with the rise of what is known in China as Political Constitutionalism in the mid-2000s, Schmitt also began to exert a more substantive terminological and conceptual influence on Chinese constitutional theory more generally, leaving his imprint on some of its fundamental theoretical binaries. Looking at the Chinese debate on Schmitt, therefore, not only grants us a unique glimpse into how constitutional debates are structured and evolving in contemporary China, it also demonstrates the often-unexpected trajectories of conceptual migration in the global age.
Variables Related to Victimization and Perpetration of Dating Violence in Adolescents in Residential Care Settings
Authors: Dosil María , Jaureguizar Joana , Bermaras Elena 
Published: October 2019

AbstractViolence in dating relationships constitutes a serious problem, thus, the study of related factors could help to better understand this violence and intervene in it. This study had three goals: (1) To analyze the prevalence of dating violence in adolescents under residential care settings according to sex and age; (2) to explore the relationships between victimization and perpetration in adolescents’ dating violence, sexist attitudes and clinical variables; and (3) to identify variables associated to adolescents’ dating violence (victimization and perpetration). The sample comprised 271 adolescents (54.6% boys and 45.4% girls), aged between 12 and 17 years (M= 15.23,SD= 1.60). The victimization (R2= .17,p&lt;.001) and perpetration(R2= .20.p&lt; .001) results showed prevalence rates higher than those of previous studies. Sex was not a differentiating factor for perpetration of dating violence, but age was: the older they were, the higher the perpetration rate. In the case of victimization, an interaction between sex and age was found. Results showed that age, sex, hostile sexism and depression were variables associated to victimization whereas age, hostile sexism and depression were associated to perpetration of dating violence.
Simplifying Age Progressions within the Cook‐Austral Islands using ARGUS‐VI High‐Resolution 40Ar/39Ar Incremental Heating Ages
Authors: Rose Joanna , Koppers Anthony A.P. 
Published: October 2019

AbstractThe Cook‐Austral islands do not exhibit a simple linear age progression from a single point of active volcanism, in contrast to other Pacific island chains. Explaining this anomaly, however, has been difficult due to the low reliability of the existing K/Ar ages for these islands. Here we present 56 new incremental heating 40Ar/39Ar age determinations for eight of the Cook‐Austral islands. We show that these 40Ar/39Ar ages are on average 10–40% different and generally older than the K/Ar ages for the same samples, are more reproducible within single lava flows, exhibit less scatter among data from a single island, and are more reliable than published K/Ar age determinations. Our new data result in two clearly defined and matching age‐progressive trends, with origins at the Macdonald and Arago seamounts. This supports the hypothesis that the Macdonald and Rurutu tracks formed by two contemporaneous hotspots aligned in the direction of plate motion. Compared to other volcanic chains on the Pacific plate, the Cook‐Austral hotspot tracks record angular rotational plate velocities (0.96 ± 0.05 to 1.09 ± 0.04°/Ma) similar to Hawaii (1.15°/Ma) but faster than Samoa (0.63°/Ma). This may imply that hot spot location relative to tectonic boundaries may have an effect on the age progressions recorded by volcanic chains. Specifically, the Cook‐Austral and Hawaii hot spots have over the last 30 Myr been located truly intraplate and thus far away from any tectonic boundary, while Samoa has been proximal to the active Tonga‐Kermedec subduction zone.
Constraints on Emplacement Rates of Intrusions in the Shallow Crust Based on Paleomagnetic Secular Variation
Authors: Giorgis Scott , Horsman Eric , Burmeister Kurtis C. , Rost Rebecca , Herbert Lauren A. , Pivarunas Anthony , Braunagel Michael 
Published: October 2019

AbstractIn small‐volume igneous intrusions, the duration of magmatism can be difficult to determine because assembly of an intrusion from component magma pulses may occur within geochronologic uncertainties. We demonstrate that the paleomagnetic record of short‐term movement of the geomagnetic pole (secular variation) can place constraints on the duration of intrusion assembly over shorter time periods. An analysis of 14C data paired with paleomagnetic data from lava flows illustrates this approach. The flows record paleosecular variation that, when combined with the maximum rate of secular variation from the Holocene, returns a minimum time elapsed between any two flows. Data from an Oligocene laccolith indicate that this system records a minimum of 49° of secular variation and therefore took at least 750 years to be emplaced. High‐precision radiometric geochronology would be unable to resolve this assembly, suggesting that the paleosecular variation record in shallow igneous rocks contains valuable temporal constraints on upper crustal magmatism.
Understanding the Signal‐to‐Noise Paradox with a Simple Markov Model
Authors: Zhang Wei , Kirtman Ben 
Published: October 2019

AbstractThere is a growing list of examples for the existence of the signal‐to‐noise paradox, where in the ensemble‐based climate prediction, the model ensemble mean forecast generally shows higher correlations with observations than with individual ensemble members. This seems to lead to a paradox that the model makes better predictions for the real world than predicting itself. Here we introduce a Markov model to represent the ensemble forecasts and reproduce the signal‐to‐noise paradox, which we argue is primarily dependent on the magnitude of the persistence and noise variance between the models and the corresponding observations. The monthly North Atlantic Oscillation indices based on uninitialized historical simulations of 40 CMIP5 models have been analyzed, suggesting that the signal‐to‐noise paradox is common in currently available coupled models, and the paradox is not due to problems with initialization processes used in the seasonal‐to‐decadal predictions in previous studies and is instead a general model problem.
Responses of Multiday Oscillations in the Nighttime Thermospheric Temperature to Solar and Geomagnetic Activities Measured by Fabry‐Perot Interferometer in China
Authors: Liu Yangkun , Xu Jiyao , Liu Xiao , Zhang Shun‐Rong , Yuan Wei , Liu Weijun , Wu Kun , Wang Chi 
Published: October 2019

AbstractThe nighttime thermospheric temperature (~250 km) measured by FPI (Fabry‐Perot interferometer) at Xinglong (40.2°N, 117.4°E) station from 2010 to 2018 is used to investigate the responses of the multiday oscillations (periods of 27, 13.5, 9, and 7 days) in thermospheric temperature to oscillations in F10.7 and Ap index. The results show that (1) the 27‐, 13.5‐, 9‐, and 7‐day oscillations in the thermospheric temperature depend on solar phases. The 27‐day oscillations are predominant during solar maximum, while the 13.5‐, 9‐, and 7‐day oscillations are significant during solar ascending phase, and (2) the 27‐day oscillations in the thermospheric temperature are highly correlated (correlation coefficient >0.8) with the F10.7 and Ap index. Especially during solar maximum phase, the high‐correlation occurrence rate between the thermospheric temperature and F10.7 (Ap index) is up to 278.5 (191.0) days per year; (3) the 13.5‐, 9‐, and 7‐day oscillations are highly correlated with Ap index during the solar descending phase; and (4) the phase lags corresponding to the largest high‐correlation occurrence rates are mostly about 0.1π during specific solar phase.
Modeling Frequency‐Independent Q Viscoacoustic Wave Propagation in Heterogeneous Media
Authors: Xing Guangchi , Zhu Tieyuan 
Published: October 2019

AbstractQuantifying the attenuation of seismic waves propagating in the Earth interior is critical to study the subsurface structure. Previous studies have proposed fractional anelastic wave equations to model the frequency‐independent Q seismic wave propagation. Such wave equations involve fractional derivatives that pose computational challenges for the numerical schemes in terms of accuracy and efficiency when dealing with heterogeneous Earth media. To tackle these challenges, here we derive a new viscoacoustic wave equation, where the power terms of the fractional Laplacian operators are spatially independent, thus accurate and efficient methods (e.g., the Fourier pseudospectral method) can be adopted. Our derivation enables the resultant equation to capture both amplitude and phase signatures of the anelastic wave propagation by matching the complex wave numbers for all the frequencies of interest. We verify the derivation by comparing the dispersion curves of both the attenuation factor and the phase velocity produced by the new wave equation with their theoretical values as well as the Pierre Shale in situ measurements. Following that, we use a synthetic attenuating gas chimney model to demonstrate the attenuation effects on seismic waveforms and then construct the Q‐compensated reverse time migration to undo these effects for seismic image enhancement. Finally, we find that our forward modeling results can characterize the spatiotemporal attenuation effects revealed in the Frio‐II CO2 injection time‐lapse seismic monitoring data. We expect this proposed equation to be useful to quantify the attenuation in seismic data to push the resolution limits of seismic imaging and inversion.
Inferring Air‐Sea Carbon Dioxide Transfer Velocities From Sea Surface Scatterometer Measurements
Authors: Ghobadian M. , Stammer D. 
Published: October 2019

AbstractC‐band microwave sea surface radar backscatter observations from the FINO‐2 tower in the western Baltic are analyzed with respect to their relevance for air‐sea CO2 transfer velocity parameterizations. The scatterometer measurements observed from a height of 25 m above the sea surface using a multifrequency scatterometer instrument of the University of Hamburg were obtained quasi‐simultaneously with eddy covariance CO2 flux measurements. Both data sets are merged here to derive a gas transfer velocity parameterization based on radar backscatter measurements. At the location of the FINO‐2 tower, the resulting time‐averaged gas transfer velocity amounts to 26.95 cm/hr. In combination with
measurements available from the vicinity of the FINO‐2 platform, a time‐mean CO2 flux of 0.23 μmol·m−2·s−1 into the Baltic was estimated. Applied to monthly mean satellite‐based C‐band ASCAT scatterometer data, the newly derived gas transfer velocity parameterization provides estimates of seasonal and annual mean global maps of air‐sea transfer velocities. The new results agree in their general pattern with previous estimates using wind speed parameterization. However, the backscatter‐based transfer velocities appear smaller at higher latitudes. Globally averaged air‐sea CO2 fluxes would thereby be reduced by 20%. To what extent this is a robust result, or if it depends on the fact that the training data set did not represent conditions, has to be investigated in the future.
Southern Ocean Phytoplankton Blooms Observed by Biogeochemical Floats
Authors: Uchida Takaya , Balwada Dhruv , Abernathey Ryan , Prend Channing J. , Boss Emmanuel , Gille Sarah T. 
Published: October 2019

AbstractThe spring bloom in the Southern Ocean is the rapid‐growth phase of the seasonal cycle in phytoplankton. Many previous studies have characterized the spring bloom using chlorophyll estimates from satellite ocean color observations. Assumptions regarding the chlorophyll‐to‐carbon ratio within phytoplankton and vertical structure of biogeochemical variables lead to uncertainty in satellite‐based estimates of phytoplankton carbon biomass. Here, we revisit the characterizations of the bloom using optical backscatter from biogeochemical floats deployed by the Southern Ocean Carbon and Climate Observations and Modeling and Southern Ocean and Climate Field Studies with Innovative Tools projects. In particular, by providing a three‐dimensional view of the seasonal cycle, we are able to identify basin‐wide bloom characteristics corresponding to physical features; biomass is low in Ekman downwelling regions north of the Antarctic Circumpolar Current region and high within and south of the Antarctic Circumpolar Current.
De novo compartment deconvolution and weight estimation of tumor samples using DECODER
Authors: Peng Xianlu Laura , Moffitt Richard A. , Torphy Robert J. , Volmar Keith E. , Yeh Jen Jen 
Published: October 2019

AbstractTumors are mixtures of different compartments. While global gene expression analysis profiles the average expression of all compartments in a sample, identifying the specific contribution of each compartment remains a challenge. With the increasing recognition of the importance of non-neoplastic components, the ability to breakdown the gene expression contribution of each is critical. Here, we develop DECODER, an integrated framework which performs de novo deconvolution and single-sample compartment weight estimation. We use DECODER to deconvolve 33 TCGA tumor RNA-seq data sets and show that it may be applied to other data types including ATAC-seq. We demonstrate that it can be utilized to reproducibly estimate cellular compartment weights in pancreatic cancer that are clinically meaningful. Application of DECODER across cancer types advances the capability of identifying cellular compartments in an unknown sample and may have implications for identifying the tumor of origin for cancers of unknown primary.
Superresolution architecture of cornerstone focal adhesions in human pluripotent stem cells
Authors: Stubb Aki , Guzmán Camilo , Närvä Elisa , Aaron Jesse , Chew Teng-Leong , Saari Markku , Miihkinen Mitro , Jacquemet Guillaume , Ivaska Johanna 
Published: October 2019

AbstractWhile it is clear that key transcriptional programmes are important for maintaining pluripotency, the requirement for cell adhesion to the extracellular matrix remains poorly defined. Human pluripotent stem cells (hPSCs) form colonies encircled by an actin ring and large stable cornerstone focal adhesions (FA). Using superresolution two-colour interferometric photo-activated localisation microscopy, we examine the three-dimensional architecture of cornerstone adhesions and report vertical lamination of FA proteins with three main structural features distinct from previously studied focal adhesions: 1) integrin β5 and talin are present at high density, at the edges of cornerstone FA, adjacent to a vertical kank-rich protein wall, 2) vinculin localises higher than previously reported, displaying a head-above-tail orientation, and 3) surprisingly, actin and α-actinin are present in two discrete z-layers. Finally, we report that depletion of kanks diminishes FA patterning, and actin organisation within the colony, indicating a role for kanks in hPSC colony architecture.
A kinase-independent role for CDK8 in BCR-ABL1+ leukemia
Authors: Menzl Ingeborg , Zhang Tinghu , Berger-Becvar Angelika , Grausenburger Reinhard , Heller Gerwin , Prchal-Murphy Michaela , Edlinger Leo , Knab Vanessa M. , Uras Iris Z. , Grundschober Eva , Bauer Karin , Roth Mareike , Skucha Anna , Liu Yao , Hatcher John M. , Liang Yanke , Kwiatkowski Nicholas P. , Fux Daniela , Hoelbl-Kovacic Andrea , Kubicek Stefan , Melo Junia V. , Valent Peter , Weichhart Thomas , Grebien Florian , Zuber Johannes , Gray Nathanael S. , Sexl Veronika 
Published: October 2019

AbstractCyclin-dependent kinases (CDKs) are frequently deregulated in cancer and represent promising drug targets. We provide evidence that CDK8 has a key role in B-ALL. Loss of CDK8 in leukemia mouse models significantly enhances disease latency and prevents disease maintenance. Loss of CDK8 is associated with pronounced transcriptional changes, whereas inhibiting CDK8 kinase activity has minimal effects. Gene set enrichment analysis suggests that the mTOR signaling pathway is deregulated in CDK8-deficient cells and, accordingly, these cells are highly sensitive to mTOR inhibitors. Analysis of large cohorts of human ALL and AML patients reveals a significant correlation between the level of CDK8 and of mTOR pathway members. We have synthesized a small molecule YKL-06-101 that combines mTOR inhibition and degradation of CDK8, and induces cell death in human leukemic cells. We propose that simultaneous CDK8 degradation and mTOR inhibition might represent a potential therapeutic strategy for the treatment of ALL patients.