bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parent and child emotion and distress responses associated with parental accommodation of child anxiety symptoms
Authors: O'Connor Erin E. , Holly Lindsay E. , Chevalier Lydia L. , Pincus Donna B. , Langer David A. 
Published: February 2020

AbstractObjectiveParental accommodation contributes to the maintenance of child anxiety and related symptoms. The current study examines the contributions of parent and child factors to parental accommodation in a sample of anxious youth.MethodsSixty‐four treatment‐seeking youth (6–16 years) and their mothers, as well as a subset of fathers (N = 41) reported on parental accommodation, parental distress and emotion regulation, child psychopathology, child externalizing behaviors, and child intolerance of uncertainty.ResultsParental accommodation was not related to parental distress or emotion regulation. Parents who viewed their child as being more symptomatic (e.g., anxious, externalizing, and intolerant of uncertainty) were more likely to engage in accommodation. For mothers, child anxiety and externalizing symptoms were notable predictors of accommodation.ConclusionsParent perceptions of child symptomology is an important factor significantly related to accommodation behaviors. This finding can be used to inform programming designed to target parental responses to child anxiety and related disorders.
Low‐wavenumber Raman scattering of phospholipid bilayers in fluid, ripple, and gel phases
Authors: Surovtsev N.V. , Adichtchev S.V. 
Published: February 2020

AbstractLow‐wavenumber Raman spectra of the aqueous suspension of multilamellar vesicles made of 1,2‐dimyristoyl‐sn‐glycero‐3‐phosphocholine have been studied. The Raman susceptibility of phospholipid bilayers was experimentally found for the gel, ripple, and fluid lipid phases. Comparison of the Raman susceptibility with the inelastic neutron and X‐ray scattering data evidences that the Raman spectrum reflects the in‐plane phonon density of states. Also, the Raman susceptibility reveals peaks below ~ 30 cm−1 associating with the off‐plane modes. These peaks were found to be sensitive to the lipid phase. In particular, the ripple spectrum included the off‐plane modes of the fluid and gel phases. The low‐wavenumber Raman spectroscopy becomes a powerful method for studying THz vibrational modes of phospholipid bilayers, corresponding to nanometer response of the bilayers.
Commentary on the Special Issue on Network Analysis: Assessment, Intervention, Theory, and the Nature of Reality: Actualizing the Potential of Network Perspectives on Posttraumatic Stress Disorder
Authors: Weems Carl F. 
Published: February 2020

AbstractThis commentary on the Journal of Traumatic Stress special issue on network analysis explores the network perspective on posttraumatic stress disorder (PTSD), emphasizing the advances in research made in this collection of articles. The commentary is organized around the following themes related to actualizing the perspective's methodological, assessment, and intervention potential and the potential shift in the theoretical underpinnings of mental disorders that networks models imply. First, extant data using network analysis suggest that reactions to traumatic stress are more complicated than once thought but that this complexity does not mean efficient, relatively simple heuristics to aid assessment and intervention do not exist. Attention to methodological issues in symptom assessment may help move this aspect of the research forward. Second, the extant research is largely correlational and has not yet established causal linkages, although temporal associations underlying network models are being identified. Prospective and intervention studies employing network analysis are critical. Third, the network perspective of PTSD symptoms may advance research on the mechanisms of risk and resilience (e.g., neurodevelopmental, cognitive behavioral, emotional, and social models) by helping link symptoms to theoretical causal processes. A developmental framework that views the effect of traumatic stress in terms of temporal cascades of reactions with both negative and potentially positive cognitive, behavioral, social, and emotional outcomes fits the network analysis model. Fourth, network models call into question some of the fundamental assumptions underlying the conceptualization of mental disorders, leaving several ontological questions and implications currently unanswered; research examining the implications of the new assumptions is needed.
Adaptive scan duration in SPECT: Evaluation for radioembolization
Authors: Dietze Martijn M. A. , Kunnen Britt , Beijst Casper , de Jong Hugo W. A. M. 
Published: February 2020

PurposeIt may be challenging to select the optimal scan duration for single‐photon emission computed tomography (SPECT) protocols because the activity distribution characteristics can differ in every scan. Using simulations and experiments, we investigated whether the scan duration can be optimized for every scan separately by evaluating the activity distribution during scanning. We refer to this as adaptive scanning.MethodsThe feasibility of adaptive scanning was evaluated for the detection of extrahepatic depositions in the pretreatment procedure of radioembolization, in which 99mTc‐labeled macroaggregated albumin (99mTc‐MAA) is injected into the liver. We simulated fast 1‐min detector rotations and updated the reconstruction with the newly collected counts after every rotation. The scan was terminated when one of the two criteria was met: (a) when the mask difference of the detected extrahepatic deposition between two consecutive rotations was lower than 5%; or (b) when the reconstructed extrahepatic activity was negligible with respect to the total reconstructed activity (<0.075%). The performance of adaptive scanning was evaluated using a digital phantom with various activity distributions, a physical phantom experiment, and simulations based on 129 patient activity distributions.ResultsThe digital phantom data showed that the scan termination times substantially depended on the activity distribution characteristics. The experimental phantom data showed the feasibility of adaptive scanning with physical scanner measurements and illustrated that fast detector motion was not limiting the adaptive scanning performance. The patient data showed a large spread in the scan terminations times. By adaptive scanning, the mean scan duration of the patient distributions was shortened from 20 min (current clinical protocol) to 4.8 ± 0.2 min. The detection accuracy of extrahepatic depositions was unaffected and the mean difference in the extrahepatic deposition masks (compared with the 20‐min scan) was only 7.0 ± 1.0%.ConclusionOur study suggests that the SPECT scan duration can be personalized by assessing the activity distribution characteristics during scanning for the detection of extrahepatic depositions in the pretreatment procedure of radioembolization. The adaptive scanning approach might also be of benefit for other SPECT protocols, as long as a measure of interest is available for optimization.
2D multislice MP2RAGE sequence for fast T1 mapping at 7 T: Application to mouse imaging and MR thermometry
Authors: Faller Thibaut L. , Trotier Aurélien J. , Rousseau Alice F. , Franconi Jean‐Michel , Miraux Sylvain , Ribot Emeline J. 
Published: February 2020

PurposeTo develop a 2D radial multislice MP2RAGE sequence for fast and reliable T1 mapping at 7 T in mice and for MR thermometry.MethodsThe 2D‐MP2RAGE sequence was performed with the following parameters: TI1‐TI2‐MP2RAGETR = 1000‐3000‐9000 ms. The multiple dead times within the sequence were used for interleaved multislice acquisition, enabling one to acquire six slices in 9 seconds. The excitation pulse shape, inversion selectivity, and interslice gap were optimized. In vitro comparison with the inversion‐recovery sequence was performed. The T1 variations with temperature were measured on tubes with T1 ranging from 800 ms to 2000 ms. The sequence was used to acquire T1 maps continuously during 30 minutes on the brain and abdomen of healthy mice.ResultsA three‐lobe cardinal sine excitation pulse, combined with an inversion slice thickness and an interslice gap of respectively 150% and 50% of the imaging slice thickness, led to a SD and bias of the T1 measurements below 1% and 2%, respectively. A linear dependence of T1 with temperature was measured between 10°C and 60°C. In vivo, less than 1% variation was measured between successive T1 maps in the mouse brain. In the abdomen, no obvious in‐plane motion artifacts were observed but respiratory motion in the slice dimension led to 6% T1 underestimation.ConclusionThe multislice MP2RAGE sequence could be used for fast whole‐body T1 mapping and MR thermometry. Its reconstruction method would enable on‐the‐fly reconstruction.
Oxandrolone in Patients on Venovenous Extracorporeal Membrane Oxygenation: A Case Series
Authors: Pelekhaty Stacy L. , Pajoumand Mehrnaz , Omanwa Kristen S. , Galvagno Jr Samuel M. , Lantry James H. , Deatrick Kristopher B. , Cornachione Christopher R. , Menaker Jay 
Published: February 2020

AbstractVenovenous extracorporeal membrane oxygenation (VV ECMO) induces a systemic inflammatory response, which may progress to persistent inflammation, immunosuppression, and catabolism syndrome (PICS). The anabolic steroid oxandrolone may improve the metabolic aberrations of PICS. We report our experience with 3 patients on VV ECMO who received oxandrolone after demonstrating refractory catabolism on serial nitrogen balance (NB) studies or persistent weakness. Patients in cases 1 and 3 were started on oxandrolone on VV ECMO days 45 and 29, respectively, for negative NB despite nutrition optimization. The case 2 patient started oxandrolone for persistent weakness 68 days after cannulation. All patients demonstrated improvements in NB results. One patient developed mild transaminitis while on oxandrolone, which did not alter his medication course and resolved after the medication was discontinued. The impact of oxandrolone on functional capacity varied between patients. Oxandrolone may be beneficial in persistently catabolic VV ECMO patients to improve NB results. In some patients, this may support functional recovery. Additional research is needed to identify optimal patients for therapy and to investigate the impact of oxandrolone in this population.
A survey on indexing techniques for mobility in Internet of Things': Challenges, performances, and perspectives
Authors: Badarneh Hazem Jihad , Ravana Sri Devi , Mansoor Ali Mohammed 
Published: February 2020

SummaryMobile nodes arouse new challenges that expand the performance in those environments. The nodes of Internet of Things (IoT) generate a large amount of data, which have to be stored and processed in a seamless and interpretable form by indexing. Therefore, indexing is a challenge in IoT, particularly when the nodes are mobile. The current indexing techniques dedicated to mobile environments are unsatisfying because the data are transmitted from different locations within different time periods and randomness of sensor movement. Although huge research efforts have been dedicated to this subject amid the last decades, little consideration has been paid for the research summarization and guidance. The objective of this survey is to identify the relationship between activities of mobile sensors in the context of IoT, that concerned on transferring and collecting data as well as the effectiveness of indexing techniques. The contribution of this review is to investigate the techniques of mobile IoT nodes, to find the source of challenges that adversely affect the index effectiveness. In‐depth investigation and analyses of approaches to apply IoT mobile nodes will enable the researcher to understand the behavior of mobile environments to extract the deformities that adversely affect the indexing effectiveness. The analyzed approaches are meta‐heuristic, spatial‐temporal indexing, and prediction model approach. Each approach is analyzed by discussing the features and limitations from the mobility perspectives. Furthermore, the indexing techniques are analyzed according to their features and limitations and mobile IoT indexing requirements. In conclusion, recognize and contemplate different open issues that got little focus or still unknown at this point.
Proteomic Study Reveals the Involvement of Energy Metabolism in the Fast Antidepressant Effect of (2R, 6R)‐Hydroxy Norketamine
Authors: Rahman Shafiq Ur , Hao Qiang , He Kaiwu , Li Yumeng , Yang Xifei , Ye Tao , Ali Tahir , Zhou Qiang , Li Shupeng 
Published: February 2020

PurposeDepression is a major disabling psychiatric disorder which causes severe financial burden and social consequences worldwide. Recently, (2R, 6R)‐hydroxynorketamine (HNK), a metabolite of ketamine, showed strong antidepressant effect through N‐methyl‐D‐aspartate (NMDA) antagonizing independent mechanism. In the current study the goal is to identify the potential intracellular molecules and pathways that might be involved in different therapeutic effects underlying HNK as compared to NMDA antagonist MK‐801.Experimental designForced‐swim behavioral test, 2D fluorescence difference gel electrophoresis, and MALDI‐TOF‐MS/MS proteomics are used.ResultsCompared to saline group, 14 differential proteins are identified in MK‐801 treated group, with six proteins significantly up‐regulated, while in HNK treated group 18 distinct proteins are identified with 11 proteins significantly up‐regulated. Likewise, two proteins are significantly upregulated in HNK treated group when compared to MK‐801 treated group. Among these differentially expressed proteins, phosphoglycerate mutase 1, malate dehydrogenase/ cytoplasmic, and triosephosphate isomerase are co‐affected by MK‐801 and HNK treatment. Representative protein expression changes are quantified by western blot, showing consistent results as determined by MALDI‐TOF‐MS/MS.Conclusion and clinical relevanceThe core protection mechanisms of HNK observed herein involves improving the abnormal ATP synthesis, impaired glycolysis, and the defense system therefore provides mechanistic insight and molecular targets for novel antidepressants.
Ultra‐Fine Aluminium Characterization and its Agglomeration Features in Solid Propellant Combustion for Various Quenched Distance and Pressure
Authors: Tejasvi K. , Venkateshwara Rao Vemana , Pydi Setty Yelamarthi , Jayaraman Kandasamy 
Published: February 2020

AbstractAddition of micrometer‐sized aluminium powder in solid propellant increases the specific impulse whereas it also contributes to thrust loss due to two‐phase flow. Aluminium particles form large sized agglomerates during propellant burning. In this context, agglomeration feature of ultra‐fine aluminium (UFAL) in solid propellant combustion is investigated using experimental study. The synthesized UFAL powder is used with the intensity weighted harmonic mean size of 438 nm which is produced by RF induction plasma method. The morphology and purity of the UFAL is verified using SEM and EDAX studies respectively. The ultra‐fine particles are also characterized using gas volumetric method, surface area measurement and XRD analysis. Quench particle collection technique is adopted to estimate the aluminium agglomerate measurement over the pressure ranges from 2 MPa to 8 MPa. The flame quenching distance from the propellant burning surface is varied from 5 mm to 71 mm to estimate the effect on agglomerate size. The inherited residual forces of UFAL strongly influences the agglomeration process, and also the aluminium agglomerate sizes vary from propellant burning surface towards the complete aluminium combustion. The XRD and XPS results of the agglomerates show that the aluminium content decreases and alumina content increases far away from the burning surface, invariably represents the initiation of combustion process over the considered quenching distances. UFAL powder exhibits significant agglomeration with the size ranging from 11–21 μm. This will substantially benefit from exhaust signature point of view and also reduction in two‐phase flow losses to thrust in contrast to micron sized‐aluminium particles in propellant which displays large sized aluminium agglomerates.
A global plastid phylogeny of the cliff fern family Woodsiaceae and a two‐genus classification of Woodsiaceae with the description of ×Woodsimatium nothogen. nov.
Authors: Lu Ngan Thi , Zhou Xin‐Mao , Zhang Liang , Knapp Ralf , Li Chun‐Xiang , Fan Xue‐Ping , Zhou Lin , Wei Hong‐Jin , Lu Jin‐Mei , Xu Bo , Peng Yu‐Lan , Gao Xin‐Fen , Zhang Li‐Bing 
Published: February 2020

AbstractThe taxonomy of the cliff fern family Woodsiaceae has been controversial with 22–59 species in 1–7 genera recognized in various classifications. This is mainly due to limited taxon sampling (up to 33 accessions representing up to 21 species) and poor resolution in molecular studies so far. In the present study, DNA sequences of five plastid markers (atpA, matK, rbcL, rps4 + rps4‐trnS, trnL + trnL‐F) of 152 accessions representing ca. 43 out of ca. 65 species estimated of Woodsiaceae (122 accessions), and 30 non‐Woodsiaceae accessions from the most closely related four families (Athyriaceae, Blechnaceae, Onocleaceae, Thelypteridaceae) were used to infer a phylogeny. Our major results include: (1) Woodsiaceae are strongly supported as monophyletic; (2) Two major clades representing the deepest split in Woodsiaceae are identified, corresponding to the two recently proposed subfamilies, Woodsioideae and Protowoodsioideae; (3) Within Woodsioideae and Protowoodsioideae, two and three well‐supported subclades, respectively, are determined; (4) Cheilanthopsis is resolved as paraphyletic in relation to Hymenocystis (sampled for the first time) and Protowoodsia; (5) Physematium and Woodsiopsis are paraphyletic in relation to a clade containing Cheilanthopsis, Hymenocystis, and Protowoodsia; (6) Evolution of 13 morphological characters is inferred in a phylogenetic context, and morphological synapomorphies of each of the five major subclades are identified; (7) We propose to recognize two genera in Woodsiaceae based on deep divergence (ca. 45 Ma), morphology, chromosome number, and geographic distribution: Physematium (syn.: Cheilanthopsis, Hymenocystis, Protowoodsia, Woodsiopsis) and Woodsia (syn.: Eriosoriopsis), and Physematium is further divided into three subgenera and Woodsia into two subgenera; (8) we describe ×Woodsimatium, a hybrid genus (nothogen. nov.) between the two genera recognized. A taxonomic synopsis of the family is provided, and 15 new combinations are made.
Oxidative stress accelerates synaptic glutamate dyshomeostasis and NMDARs disorder during methylmercury‐induced neuronal apoptosis in rat cerebral cortex
Authors: Yang Tianyao , Xu Zhaofa , Liu Wei , Xu Bin , Deng Yu 
Published: February 2020

AbstractMethylmercury (MeHg) is a potent neurotoxin,which leads to a wide range of intracellular effects. The molecular mechanismsassociated to MeHg‐induced neurotoxicity have not been fully understood.Oxidative stress, as well as synaptic glutamate (Glu) dyshomeostasis have beenidentified as two critical mechanisms during MeHg‐mediated cytotoxicity. Here,we developed a rat model of MeHg poisoning to evaluate its neurotoxic effectsby focusing on cellular oxidative stress and synaptic Glu disruption. Inaddition, we investigated the neuroprotective role of alpha‐lipoic acid (α‐LA), a natural antioxidant, todeeply explore the underlying interaction between them. Fifty‐six rats wererandomly divided into four groups: saline control, MeHg treatment (4 or 12μmol/kg MeHg), and α‐LApre‐treatment (35 μmol/kg α‐LA+12μmol/kg MeHg). Rats exposed to 12 μmol/kg MeHg induced neuronal oxidativestress, with ROS accumulation and cellular antioxidant system impairment. Nrf2 andxCT pathways were activated with MeHg treatment. The enzymatic or non‐enzymaticof cellular GSH synthesis were also disrupted by MeHg. On the other hand, the abnormalactivities of GS and PAG disturbed the “Glu‐Gln cycle”, leading to NMDARsover‐activation, Ca2+ overload, and the calpain activation, which acceleratedNMDARs degradation. Meanwhile, the high expressions of phospho‐p44/42 MAPK,phospho‐p38 MAPK, phospho‐CREB, and the high levels of caspase 3 and Bax/Bcl‐2 finallyindicated the neuronal apoptosis after MeHg exposure. Pre‐treatment with α‐LA significantly preventedMeHg‐induced neurotoxicity. In conclusion, the oxidative stress and synapticGlu dyshomeostasis contributed to MeHg‐induced neuronal apoptosis. Alpha‐LAattenuated these toxic effects through mechanisms of anti‐oxidation andindirect Glu dyshomeostasis prevention
NNLO QCD + NLO EW with Matrix+OpenLoops: precise predictions for vector-boson pair production
Authors: Grazzini M. , Kallweit S. , Lindert J.M. , Pozzorini S. , Wiesemann M. 
Published: February 2020

Abstract
We present the first combination of NNLO QCD and NLO EW corrections for vector-boson pair production at the LHC. We consider all final states with two, three and four charged leptons, including resonant and non-resonant diagrams, spin correlations and off-shell effects. Detailed predictions are discussed for three representative channels corresponding to W+W−, W±Z and Z Z production. Both QCD and EW corrections are very significant, and the details of their combination can play a crucial role to achieve the level of precision demanded by experimental analyses. In this context we point out nontrivial issues that arise at large transverse momenta, where the EW corrections are strongly enhanced by Sudakov logarithms and the QCD corrections can feature so-called giant K -factors. Our calculations have been carried out in the Matrix+OpenLoops framework and can be extended to the production of an arbitrary colour singlet in hadronic collisions, provided that the required two-loop QCD amplitudes are available. Combined NNLO QCD and NLO EW predictions for the full set of massive diboson processes will be made publicly available in the next release of Matrix and will be instrumental in advancing precision diboson studies and new-physics searches at the LHC and future hadron colliders.
The Role of Extracellular DNA and Histones in Ischaemia-Reperfusion Injury of the Myocardium
Authors: Shah Mohammed , Yellon Derek M. , Davidson Sean M. 
Published: February 2020

AbstractDespite an increase in the rates of survival in patients suffering myocardial infarction, as yet there is no therapy specifically targeting ischaemia and reperfusion injury of the myocardium. With a greater understanding of immune activation during infarction, more potential treatment targets are now being identified. The innate immune system is believed to play an important role in the myocardium after ischaemia-driven cardiomyocyte death. The release of intracellular contents including DNA into the extracellular space during necrosis and cell rupture is now believed to create a pro-inflammatory milieu which propagates the inflammatory process. DNA and DNA fragments have been shown to activate the innate immune system by acting as Danger-Associated Molecular Patterns (DAMPs), which act as ligands on toll-like receptors (TLRs). Stimulation of TLRs, in turn, can activate intracellular cell death pathways such as pyroptosis. Here, we review the role of DNA fragments during ischaemia and reperfusion, and assess their potential as a target in the quest to preserve cardiomyocyte viability following myocardial infarction.