bluuebunny/crossref_metadata_2025_split huggingface dataset:
Putting a federal capacities assessment to work: blueprint for a national program for the early detection of and rapid response to invasive species (EDRR)
Authors: Reaser Jamie K. 
Published: December 2019

AbstractThis paper responds to national policy directives intended to improve the US government’s capacity to protect national security from the adverse impacts of invasive species. It is the final, synthesizing contribution to a Special Issue of Biological Invasions comprising 12 papers that collectively inform the development and implementation of a national program for the early detection of and rapid response to invasive species (EDRR). The blueprint sets forth policies, goals, and actions to be taken by relevant Executive Branch agencies and components of the Executive Office of the President to develop a national EDRR program, appropriations permitting. It is designed to function as guidance for advancing federal policy through Presidential, Secretarial, and/or Congressional directives. Those committed to protecting national security, the economy, and the well-being of American people are forewarned that our ability to establish a national EDRR program is undermined by the diminishment of the federal workforce; institutional structures, policies, and programs; and directly applicable leadership mechanisms, including the National Invasive Species Council, Invasive Species Advisory Committee, and their managerial Secretariat.
Costs and long-term outcomes following pulmonary vein isolation for atrial fibrillation in elderly patients using second-generation cryoballoon vs. open-irrigated radiofrequency in China
Authors: Chen Chao-feng , Liu Mei-jun , Jin Chao-lun , Gao Xiao-fei , Liu Xiao-hua , Xu Yi-zhou 
Published: December 2019

Abstract
Purpose
Limited comparative data are available regarding catheter ablation (CA) of atrial fibrillation (AF) using second-generation cryoballoon (CB-2) vs. radiofrequency (RF) ablation in elderly patients (> 75 years old). The present study aimed to compare the costs and clinical outcomes in elderly patients using these two strategies.

Methods
Elderly patients with symptomatic drug-refractory paroxysmal/short-lasting persistent AF were included in the study. Pulmonary vein isolation (PVI) was performed in all patients.

Results
A total of 324 elderly patients were included (RF,176; CB-2,148) from September 2016 to April 2019. The CB-2 was associated with shorter procedure time and left atrial dwell time (112.9 ± 11.1 vs. 135.1 ± 9.9 min, P < 0.001; 53.7 ± 8.9 vs. 65.1.9 ± 9.0 min, P < 0.001) but marked fluoroscopy utilization (22.1 ± 3.3 vs. 18.5 ± 3.6 min, P < 0.001). Complications occurred in 3.3% (CB-2) and 6.2% (RF) of patients with no significant different (p = 0.307). The length of stay after ablation was shorter, but the costs were higher in the CB-2 group (1.94 vs. 2.53 days, P < 0.001 and 91,132.6 ± 3723.5 vs. 81,149.4 ± 6824.1 CNY, P < 0.001) compared to the RF group. Additionally, the rate of early recurrence of atrial arrhythmia (ERAA) was lower in the CB-2 group (14.2 vs. 23.3%, P = 0.047), but the long-term success rate was similar between two groups.

Conclusions
CB-2 is associated with shorter procedure time, left atrial dwell time, and length of stay after ablation, as well as lower ERAA, but its costs and fluoroscopy time are greater than the RF group. Moreover, the rate of complications and long-term success is similar between the two groups.
Associations between Adolescents’ Interpersonal Relationships, School Well-being, and Academic Achievement during Educational Transitions
Authors: Kiuru Noona , Wang Ming-Te , Salmela-Aro Katariina , Kannas Lasse , Ahonen Timo , Hirvonen Riikka 
Published: December 2019

AbstractA youth’s ability to adapt during educational transitions has long-term, positive impacts on their academic achievement and mental health. Although supportive relationships with parents, peers, and teachers are protective factors associated with successful educational transitions, little is known about the reciprocal link between the quality of these interpersonal relationships and school well-being, with even less known about how these two constructs affect academic achievement. This longitudinal study examined how the quality of interpersonal relationships and school well-being worked together to affect academic achievement during the transition from primary school to lower secondary school. Data were collected from 848 Finnish adolescents (54% girls, mean age at the outset 12.3 years) over the course of sixth and seventh grade. The results support a transactional model illustrating the reciprocal associations between the quality of interpersonal relationships and school well-being during the transition to lower secondary school. As such, the presence of high quality interpersonal relationships promoted higher academic achievement through increased school well-being, whereas high school well-being promoted higher subsequent academic achievement through increased quality of interpersonal relationships. Overall, the results suggest that promoting learning outcomes and helping adolescents with challenges during educational transitions is a critical part of supporting school well-being and the formation of high-quality interpersonal relationships.
Screening of halogenated phenolic compounds in plasma and serum from marine wildlife
Authors: Lindqvist D. 
Published: December 2019

AbstractThe growing knowledge of the impact of halogenated phenolic compounds on hormonal and metabolic systems has led to an increased interest in the exposure and potential effects of these compounds in wildlife. In the present study, a screening procedure was developed to detect and quantify halogenated phenolic compounds in serum and plasma from marine wildlife. A mass spectral library containing selective ion monitoring data was created using gas chromatography electron capture negative ionization mass spectrometry. The selective ion monitoring data in the library were accompanied with retention indices to increase the specificity of each entry in the library. The library together with the developed extraction procedure and optimized instrumental settings can be used for the detection of 52 different halogenated phenolic compounds of environmental concern, including 23 hydroxylated polychlorinated biphenyls and 24 hydroxylated polybrominated diphenyl ethers. The instrument limit of detection for the compounds included in the library ranged from 30 to 320 fg/injection, with a median detection limit of 90 fg/injection. The average recovery of 11 different halogenated phenolic compounds, from four species of marine wildlife, was 66 ± 14%. A full-scan mass spectral library was also created containing an additional seven compounds. Gray seals, long-tailed ducks, and two species of fish from the Baltic Sea were screened for halogenated phenolic compounds using the developed procedure. A total of 33 compounds included in the library were detected and quantified.
Dynamic Characteristics of Deep Dolomite Under One-Dimensional Static and Dynamic Loads
Authors: Wang Jianguo , Liu Yang , Li Kegang 
Published: December 2019

AbstractThe failure characteristics of rock subjected to impact disturbance under one-dimensional static axial compression are helpful for studying the problems of pillar instability and rock burst in deep, high geostress surrounding rock under blasting disturbances. Improved split Hopkinson pressure bar equipment was used for one-dimensional dynamic–static combined impact tests of deep-seated dolomite specimens under axial compression levels of 0, 12, 24, and 36 MPa. The experimental results demonstrate that the dolomite specimens exhibit strong brittleness. The dynamic strength always maintains a strong positive correlation with the strain rate when the axial compression is fixed; when the strain rate is close, the dynamic elasticity modulus and peak strength of the specimens first increase and then decrease with the increase in axial compression, and the peak value appears at 24 MPa. The impact resistance of specimens can be enhanced when the axial compression is 12 or 24 MPa, but when it increases to 36 MPa, the damage inside the specimen begins to cause damage to the dynamic rock strength. Prior to the rock macroscopic failure, the axial static load changes the rock structure state, and it can store strain energy or cause irreversible damage.
Association of sleep, screen time and physical activity with overweight and obesity in Mexico
Authors: Kolovos Spyros , Jimenez-Moreno Aura Cecilia , Pinedo-Villanueva Rafael , Cassidy Sophie , Zavala Gerardo A. 
Published: December 2019

Abstract
Purpose
Approximately 70% of adults in Mexico are overweight or obese. Unhealthy lifestyle behaviors are also prevalent. We examined the association of three lifestyle behaviors with body mass index (BMI) categories in adults from Mexico.

Methods
We used publicly available data from the ENSANUT 2016 survey (n = 6419). BMI was used to categorize participants. Differences in sleep duration, suffering from symptoms of insomnia, TV watching time, time in front of any screen, vigorous physical activity (yes vs no), moderate physical activity (> 30 min/day—yes vs. no) and walking (> 60 min/day—yes vs. no) were compared across BMI groups using adjusted linear and logistic regression analyses.

Results
Thirty-nine percent of participants were overweight and 37% obese. Time in front of TV, in front of any screen, sleep duration and physical activity were significantly associated with overweight and obesity. Compared to normal weight participants, participants in the obese II category spend on average 0.60 h/day (95% CI 0.36–0.84, p = 0.001) and participants in the obese III category 0.54 h/day (95% CI 0.19–0.89, p < 0.001) more in front of any screen; participants in the obese II category reported 0.55 h/day less sleep (95% CI − 0.67 to − 0.43, p < 0.001); participants in the obese III category were less likely to engage in vigorous activity (OR = 0.60, 95% CI 0.43–0.84, p ≤ 0.003), or walking (OR = 0.65, 95% CI 0.49–0.88, p = 0.005).

Conclusion
Screen time, sleeping hours, and physical activity were associated with overweight and obesity. However, these associations were not consistent across all BMI categories. Assuming established causal connections, overweight individuals and individuals with obesity would benefit from reduced screen time and engaging in moderate/vigorous physical activity.

Level of evidence
Level III: observational case-control analytic study.
Dependence of fluid flow on cleat aperture distribution and aperture–length scaling: a case study from Gondwana coal seams of Raniganj Formation, Eastern India
Authors: Bandyopadhyay Krishanu , Mallik Jyotirmoy , Ghosh Trishit 
Published: December 2019

AbstractDimensions and mutual relationships amongst fracture (cleat) parameters such as maximum aperture width, average aperture width, length, spacing etc. control the connectivity within a fracture network and the fluid flow in a coal seam as the matrix permeability, here, is negligible. In this paper, we document cleat size distributions and investigate length–aperture relationships from coals of Raniganj coalfield in Eastern India. This coalfield has a proven extractable reserve of six billion tons of coal and holds immense potential to be one of the largest coal bed methane fields serving India’s growing energy needs. Here, cleat length (L) correlates with corresponding maximum aperture width (Dmax) in a power-law function with an exponent of 0.84 (DmaxαL0.84) instead of the commonly observed exponents of 1 or 0.5 applicable for other natural ‘opening-mode’ fractures. The conventional wisdom pertains that laminar fluid flow (Q) through an isolated, smooth-walled, parallel-plate fracture, embedded in an impermeable matrix, is directly proportional to the cube of its aperture width (b, equivalent toDavg; cubic law:Qαb3). This assumes a linear relationship between length and fracture aperture. However, the modified relationship between cleat length and average aperture width changes the cubic law applicable for Raniganj coal seam and now fluid flow correlates with aperture width in a power-law function with an exponent of 4.25 (Qαb4.25) instead of 3 (cube). Such simplifications will come handy for the modeling and estimation of fluid flow as it will reduce the effort of cleat length measurement which is anyway difficult and can be misleading due to the risk of undersampling.
Small State Representative
Authors: Pasipanodya Tafadzwa 
Published: December 2019

I am honored to be here, in San Francisco, representing a small developing country.Right from the conception of my state, Small Developing Country X, following decolonization in the 1960s, we have engaged with this whole global project on the premise that there is an ever-increasing economic pie. We have acted on the assumption of the nation-state leading a process of expanding economic and social well-being of its citizens through international cooperation and solidarity. But as we all know, this assumption is under threat today. World economic expansion is under threat. The real wealth of the world, not just the economic wealth, may be shrinking. And, the well-being of our vulnerable populations is becoming further impaired.
OP10 Approaches To Gain Reimbursement For Medical Devices In Germany
Authors: Neeser Kurt , Müller Elvira , Oelze Ilse-Barbara 
Published: December 2019

IntroductionMedical devices (MDs) differ regarding their risk class (I to III), operational area (in-, outpatient), intended use (diagnostic, monitoring, intervention), and with regard to available clinical evidence. Therefore, the market access processes as well as the approach of gaining reimbursement differ significantly. From a variety of potential approaches the underlying analysis illustrates five MD-specific processes.MethodsBased on a systematic search of publicly available regulations the main pathways of potential reimbursement for MDs were evaluated.ResultsMDs to be used in the in-patient setting can be divided into three categories: an innovative MD (a) is exceeding a current reimbursement framework (German Operations and Procedures Key (OPS) / diagnosis related groups (DRG)), (b) falls within an existing reimbursement rate, or (c) the MD is based on a known mode of action (MoA) for which already adequate reimbursement exists. Due to less empirical data from MDs for a) and b), a health technology assessment (HTA) is required before inclusion in a DRG, whereas a MD with known concept (c) will be grouped into existing price structures. Initiators of these processes are hospitals through a so-called NUB application. MDs entering the outpatient sector are covered by another reimbursement catalogue (EBM/GOÄ) and have to pass an assessment by the G-BA (rapid HTA) if based on new MoA (d). Such an assessment can only be initiated by respective umbrella organizations of service providers (e.g. KBV (National Association of Statutory Health Insurance Physicians)). MDs not being positively recommended by the G-BA are not reimbursable. For MDs (e) with known MoA no HTA is required.ConclusionsFor a successful market launch including sufficient reimbursement not only the market potential, but also the specific regulatory pathways have to be considered carefully. New and innovative MDs in the outpatient sector may have a longer application process to gain a positive reimbursement decision than MDs used in inpatient setting.
OP33 Treatment Of Mitral Insufficiency And Multicriteria Decision-Making
Authors: Désy François , Goetghebeur Mireille , Nicolae Maria Vutcovici , Lambert Laurie , de Guise Michèle 
Published: December 2019

IntroductionControversy regarding the efficacy of transcatheter mitral valve repair with a clip (TMVRc) in reducing the mitral regurgitation is related to the lack of solid scientific evidence. Worldwide, refusal or conditional acceptance for implementation of TMVRc, reflect ongoing uncertainty. We sought to apply a systematic multicriteria framework to ensure a fair and reasonable decision regarding the use of TMVRc in Quebec.MethodsThe framework included the following domains: context, quality of evidence concerning safety, efficacy and effectiveness, unmet patient needs, expected volume of patients, and impact on the health system including costs. Each domain within the framework was examined by a review of the literature and through consultations with a scientific advisory committee, a TMVRc clinical expert committee, TMVRc clinical teams, industry representatives and the Institut national d'excellence en santé et en services sociaux (INESSS) clinical excellence committee.ResultsThe literature review indicated that uncertainty about the efficacy and effectiveness of TMVRc persists, particularly in the real world context, and this view was supported by scientific experts. The TMVRc clinical teams provided insight into the burden of mitral insufficiency on patients and the health system and their belief in the promise of TMVRc. They also highlighted the challenges of patient selection and organizational issues related to the introduction of TMVRc within their institutions. The advisory committee stressed the need for further evaluation prior to wide diffusion.ConclusionsUsing a multicriteria framework facilitated a more standardized and transparent approach to our literature review and consultations as well as to the development of the proposed recommendations. This was especially important in the context of an evaluation of a promising new approach to treat mitral valve disease with many important uncertainties. This multi-criteria approach will facilitate a more standardized process for deliberation on how new health technologies should be implemented into the Quebec health system.
OP41 Intercultural Medical Decision Support System Using Natural Language Processing (NLP)
Authors: Gökgöl Merve , Orhan Zeynep 
Published: December 2019

IntroductionThis study aimed to reach patients using different languages while providing an opportunity to enter symptoms in their everyday language text besides medical expressions of symptoms.MethodologyNamed entity recognition (NER) techniques, based on natural language processing (NLP), were applied to develop a language independent predictive model. The research was based on extracting symptoms entered to the system by patient using NER method of NLP. In order to implement the system, python was used while pre-processing the data and string similarity function was used to estimate similarity with disease symptoms. Two sets were used for classification, one including only symptoms, and the other the matching diseases. Four thousand two hundred and eighty different symptoms were processed for the corresponding 880 diseases.ResultsEach user symptom had a similarity score for each symptom in all diseases. Top N results with highest similarities were chosen from this list. The final N results are matched with diseases. According to these results, matched diseases were ordered in terms of the percentage of matched symptoms in the disease's symptoms. Extracted terms were implied as an input of the model and analysed for a matching diagnosis where an accuracy of 83 percent was accomplished when it is tested and compared using Mayo Clinic data for specific foreign languages other than English.ConclusionThis language independent online diagnostic tool is a solution for both personal and clinical use and provides maintainable, updatable and more reliable diagnostics. This tool is particularly relevant today, with global mobility growing at a rate faster than the world`s population. We aim to upgrade the system by adding speech recognition and engaging it with the background (if available, electronic health records) of the patient.
OP112 Project Management for EUnetHTA Non-Pharmaceutical Technologies
Authors: De Villiers Cecilia , Ettinger Sabine , Erdos Judit 
Published: December 2019

IntroductionThe European Network for Health Technology Assessment (EUnetHTA) facilitates and produces Health Technology Assessments (HTA) across Europe. Project Management (PM) provides the coordination and strategic overview of assessment production and enables the flow of scientific knowledge and assessment publications through collaboration and standardized processes, procedures and documentation.MethodsEUnetHTA established a central PM function at the Ludwig Boltzmann Institute for HTA (LBI-HTA) for central coordination and assessment production of non-pharmaceutical technologies. LBI-HTA subsequently pursued capability and capacity through a decentralized hub-and-spoke-PM model with six activity centers (AC) providing decentralized coordination and PM of assessments. LBI-HTA provided central oversight and supervision with training days, e-meetings and ad hoc e-mail and telephone support as required. This was complemented by standardized operating procedures (SOPs) in the online Companion Guide (CG). A qualitative data collection via electronic questionnaires collected feedback from AC-PM, LBI-HTA-PM and assessment authors. Specific questions with free-text responses assessed current experiences, challenges, recommendations, communication and task distributions of the centralized and decentralized PM processes from these different perspectives.ResultsThe feedback concluded that PM is a separate, well-defined and important role for assessment coordination and production. The AC-PM received adequate training from the central PM and authors experienced no difference between projects managed centrally or decentrally. The CG and SOPs are important for guiding standard practice and allowing AC-PM to operate independently. Challenges were around extended timelines due to complex topics, external stakeholder involvement, insufficient team communication and not yet published SOPs resulting in additional central support.ConclusionsDecentralized coordination of assessments, knowledge management and governance achieve scale, capacity and capability through a designated pool of agencies with established roles and growing experience in sustainable collaboration of HTA production. Valuable insight into the PM model's operational efficiency, avoidance of duplication and resource savings potentially provides a sustainable post 2020 European network policy and efficiency model for high quality HTA assessment production.