bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promoting educational work using modern educational assessment tools: Creating and implementing rubrics for assessing projects and the cultivation of 21st-century skills
Authors: Kouloumpis Dionisios , Papageorgiou Theodora , Îšasimatis Îšaterina 
Published: January 2020

The purpose of this study is to highlight the effectiveness of the use of rubric as a modern technique for teaching and assessing educational work. More specifically, our purpose is to explore the benefits of the implementation of the rubric for the project assessment in comparison with other traditional assessment techniques as far as the development of skills and the improvement of the educational work is concerned. The analytical rubric that was created and employed in the study included the following criteria (each with pre-determined quality levels): content completeness, structure and organisation, creativity, development of skills and cognitive concepts. This processing tool automatically quantifies the gradient of the criteria and automatically completes the final descriptive evaluation. It has a modern pedagogical scientific approach and flexibility, which gives impetus to creative projects in school. Six teachers of a Greek high school in Athens participated in the study. Data were collected through a semi-structured interview. The nature of the study was qualitative. The results revealed that the rubric can replace any other traditional technique. The tool allowed the students to evaluate their efforts, thus allowing them to realise the usefulness of the rubric as a self-assessment tool. Moreover, by using the rubric the students and the teachers had the chance to communicate constructively. The teachers and the students assessed the rubric in a positive way as the students were led to self-assessment processes through reflection and feedback and the development of cognitive and metacognitive skills.
Keywords: Authentic assessment project, rubric, assessment criteria, reflection, 21st-century skills.
Korpus uteri kanserlerinin epidemiyoloji ve sağ kalım özellikleri
Authors: AKMAN Levent , YILDIRIM Nuri , TEREK Mustafa Coşan , ÖZSARAN Zeynep , ALANYALI Senem , HAYDAROĞLU Ayfer , ŞANLI Ulus Ali , GÖKER Erdem , ZEKİOĞLU Osman , ÖZDEMİR Necmettin , ÖZSARAN Ahmet Aydın 
Published: January 2020

Amaç: Ege Üniversitesi Hastanesinde 1992-2017 arası kanser tanı ve tedavisi yapılan 3379 korpus uteri kanserinin epidemiyolojik ve sağ kalım özelliklerini analiz etmek ve sonuçları literatürle karşılaştırmaktır.
Gereç ve Yöntem: Ege Üniversitesi Kanserle Savaş Araştırma ve Uygulama Merkezi tarafından toplanan korpus uteri kanseri verileri CANREG özel bilgisayar programına kayıt edilmiş, DSÖ ve SEER sistemleri temelinde gruplanarak analizler yapılmıştır. İstatistik analizlerde Ki-kare, General Linear Model, Kaplan Meier sağ kalım analizleri uygulanmıştır. Kaplan Meier Sağ kalım analizinde Log Rank (Mantel-Cox), Breslow (Generalized Wilcoxon) ve Tarone-Ware istatistikleri kullanılmıştır. İstatistik analizlerde p
The Impacts Of Inbound Tourism Activities And Macroeconomic Variables On Environmental Degradation In Asean-4
Authors: Widiarso Ekan , Wilantari Regina Niken , Luthfi Agus 
Published: January 2020

This study aims to analyze the impacts and causal relationship between inbound tourism activities and macroeconomic variables on environmental degradation and to analyze the environmental degradation response due to shocks that occur in inbound tourism activities and macroeconomic variables in four countries with the highest international tourist visits in the ASEAN region of Indonesia, Malaysia, Singapore and Thailand known as ASEAN-4 for Periode 1995-2015. The method used in the research is panel vector error correction model (PVECM). The results showed that inbound tourism activities positively influence in the long-term and short-term environmental degradation in ASEAN-4. Among macroeconomic variables only gross domestic product (GDP) positively affects environmental degradation in the long term and short term whereas energy consumption only affects environmental degradation in the short term. There is a direct causal relationship of inbound tourism activity with environmental degradation and environmental degradation with GDP. Energy consumption and environmental degradation manifest bidirectional causality with a feedback effect. Impulse response function indicates environmental degradation responds negatively to the shocks that occur in Inbound tourism and GDP activities. The positive response is indicated by environmental degradation in case of shock to energy consumption.
Perforacja żołądka jako powikłanie endoskopowej cholangiopankreatografii wstecznej – opis przypadku
Authors: Modrzejewski Andrzej , Śledź Marcin , Parafiniuk Mirosław , Paśnik Bartosz , Nowak Tomasz 
Published: January 2020

ABSTRACTEndoscopic retrograde cholangiapancreatography (ERCP) is an invasive diagnostic and therapeutic procedure in bile duct diseases. These procedures have severe complications, yet gastric perforation hasn’t been presented in literature.We present a case study of an 82 year old woman admitted to hospital due to suspected choledocolithiasis. The patient underwent two ERCP procedures. Due to acute abdominal pain, abdominal radiography was also performed. The examination revealed intraperitoneal free air. The patient underwent open repair of the perforated stomach. The second day after surgery the patient suffered multiorgan failure and was transmitted to the intensive care unit where she died 2 days later.
Analysis of the reasons for ambulance being called for out of hospital sudden cardiac arrest. A retrospective multi-center study
Authors: Kłosiewicz Tomasz , Skitek-Adamczak Ilona , Zieliński Marcin , Zalewski Radosław , Dąbrowski Marek , Rut Andrzej , Maciejewski Adrian 
Published: January 2020

Abstract

Introduction: The survival of sudden cardiac arrest (SCA) in addition to rapid diagnosis, implementation of high-quality cardiopulmonary resuscitation, immediate defibrillation also depends on the effective dispatching and cooperation of the emergency medical team members.

Materials and methods: The research was a retrospective analysis of medical documentation kept in 2015. The provisions regarding interventions were analyzed in patients who were diagnosed with sudden cardiac arrest during the first medical contact undertaken by the emergency medical team – a total of 1136 events.

Results: The mean age of SCA patients was 69.33 years. The main reason of calls was SCA (26.53%) and loss of consciousness (22.53%) although more than half of calls were connected other medical problems.

Conclusions: The results allow you to conclude, that calls such as syncope, chest pain or breathing disorders should be treated as high priority and dispatcher assistance until ambulance arrival should be performed to ensure rapid instructions in case of SCA.
Selected health problems of patients with acute pancreatitis treated in intensive care units
Authors: Polek Joanna , Radosz Zuzanna , Kozień Michał , Gniadek Agnieszka 
Published: January 2020

Abstract

Introduction: Acute pancreatitis (pancreatitis acuta) is one of the most common inflammatory diseases of the digestive system. It is a non-neoplastic disease characterized by an acute and rapid course. It is characterized not only by inflammatory changes in the pancreas itself but also in the surrounding tissues, and is associated with multiple organ failure in a severe stage of the disease. The aim of the study was to assess the frequency of occurrence of problems from acute pancreatitis and to present actions to eliminate them.

Materials and methods: The medical records of 50 patients with acute pancreatitis treated in an intensive care unit were analyzed. A survey form was used to input data from the medi cal records and provide scales for assessing the severity of acute pancreatitis. Correlations between selected variables were calculated.

Results: The majority were sick men aged 50+ who were retired for acute pancreatits. The most common cause of pancreatitis (n = 16) was alcohol dependence syndrome. The highest percentage of patients (n = 36) had necrotic – haemorrhagic forms of acute pancreatitis. No relationship was found between the length of stay of the patients in intensive care and the occurrence of such nursing problems as edema. In contrast, patients fed parenterally had a tendency to hyper-glycaemia. 16 respondents according to the Apache II scale had a 40% risk of death.

Conclusions: In acute pancreatitis, due to the limited independence of the patient, nursing care is very important, with the main goal to increase the patient’s comfort. It requires the cooperation of the entire therapeutic team with the patient and his family.
SAPHO syndrome in children – case reports
Authors: Wojciechowski Piotr , Strzelczuk-Judka Lidia , Klimecka Iwona , Jończyk-Potoczna Katarzyna 
Published: January 2020

Abstract

Introduction: SAPHO syndrome is a heterogeneous disease of unknown pathogenesis characterized by osteoarthritis and concomitance of skin lesions. The most common sites of lesions are sterno-clavicular joints and sterno-costal joints. Skin symptoms include palmoplantar pustulosis and acne lesions. The disease can occur in any age group, the spectrum of symptoms is broad and characterized by different dynamics of changes.

Cases report: The paper presents cases of SAPHO syndrome and diagnostic difficulties connected with it from case reports of two pediatric patients aged 10 and 8 years admitted to the hospital due to pain of the sternocostoclavicular region. Differential diagnoses included oncological, hematological, infectious, orthopedic, immunological and rheumatological diseases.
Diagnostic imaging showed characteristic changes in the affected regions. The disease process corresponded to SAPHO syndrome. Follow up visits by the patients are presented to evaluate the effectiveness of treatment, including magnetic resonance imaging and computer tomography.

Conclusions: The presented cases indicate attention to the possible course of SAPHO syndrome. It is an interdisciplinary disease, which should not be forgotten as one of differential diagnosis of patients in each age group. Early confirmation of the diagnosis allows the use of appropriate treatment and avoidance of unnecessary diagnostic procedures.
Primary tumours of the optic nerve and the optic nerve sheath
Authors: Krasodomska Kamila , Lubiński Wojciech , Masztalewicz Marta , Cyryłowski Lech 
Published: January 2020

Abstract

Introduction: Glioma and meningioma, the 2 most common primary tumours of the optic nerve and optic nerve sheath are usually benign, slow-growing tumours.
The aim of the paper is to provide an overview of clinical, histo-logical and radiological features of the most common primary tumours of the optic nerve and optic nerve sheath, as well as to discuss available treatment options.

Materials and methods: A literature review was performed based on articles discussing optic nerve glioma and meningioma of the optic nerve sheath.

Results: Glioma is the most common primary tumour of the optic nerve. In 90% of the patients, the onset is within the first 2 decades of life. Meningioma is the most common primary tumour of the optic nerve sheath. In 95% of the sufferers, the onset is in adulthood. Although rare in the general population, primary tumours of the optic nerve and its sheath are seen more often in patients with neurofibromatosis (NF). Glioma more
often affect patients with NF1, whereas meningiomas more often affect those with NF2. Unlike in children, optic nerve glioma in adults can be malignant. On the other hand, optic nerve sheath meningioma tends to be more malignant in children rather than in adults. The symptoms of optic nerve glioma and optic nerve sheath meningioma can be similar, including vision impairment and proptosis. The diagnosis is based on orbital imaging with magnetic resonance image (MRI) or computed tomography (CT). The management most often involves clinical observation. Surgery, radiation therapy or chemotherapy are only used in selected cases with the risk of optic chiasm or fellow optic nerve involvement.

Conclusions: Primary tumours of the optic nerve and optic nerve sheath are rare. Consolidated knowledge and improved understanding can aide early diagnosis and proper management of such cases.
Prevalence of Demodex spp. in students and employees of the Pomeranian Medical University in Szczecin
Authors: Dołęgowska Katarzyna 
Published: January 2020

Abstract
Introduction: Demodex folliculorum and Demodex brevis are mites living in the hair follicles and sebaceous glands of humans, with infestation usually being asymptomatic.
In the present study the prevalence and number of mites, together with influencing factors of Demodex infestation, were investigated in students and personnel of the Pomeranian Medical University in Szczecin in Poland (PUM). The prevalence of 2 Demodex species, Demodex folliculorum and Demodex brevis, was compared in epilated eyelashes and skin scrapings derived from healthy volunteers.
Materials and methods: The study was conducted on 217 healthy volunteers – females and males. The study group consisted of 114 students and 103 employees of PUM. From each study participant, 2–3 eyelashes from each lid were epilated. From 99 volunteers, skin scrapings and/or secretions from sebaceous glands were also obtained. Demodicosis was diagnosed when Demodex eggs, larvae or adult mites were identified under microscopic examination.
Results: The infestation rate of Demodex (in epilated eyelashes and skin) among the 217 volunteers was 21%. Prevalence of hair follicle mites among personnel and students were 28% and 14% respectively. The mean number of mites among the 217 patients was 2.52 ±2.48 (3.16 ±2.9 in PUM personnel and 1.46 ±0.83 in students). The infestation rate increased with age (p = 0.0005). Demodex folliculorum infested 78% (p = 0.005) of the participants and 87.5% of epilated eyelashes (p = 0.000001). Demodex brevis was more frequent on the skin (67%; p = 0.00001). Hair follicle mites were detected more often in epilated eyelashes originating from the lower lid (p = 0.000001). Moreover, a weak correlation between the presence of selected symptoms (blepharedema, conjunctivitis, burning and itching of eyelids) and Demodex infestation was observed. There was no statistically significant association between Demodex infestation and an influencing factor: work using a microscope (p = 0.92).
Decline Curve Analysis Using Type Curves
Authors: Fetkovich M. J. 
Published: January 2020

ABSTRACT
This paper shows that the decline-curve analysis approach does have a solid fundamental basis. The exponential decline is shown to be a longtime solution of the constant-pressure case. The constant-pressure infinite and finite reservoir solutions are placed on a common dimensionless curve with all the standard "empirical" exponential, hyperbolic, and harmonic decline-curve equations. Simple combinations of material balance equations and new forms of oil well rate equations for solution-gas drive reservoirs illustrate under what circumstances specific values of the hyperbolic decline exponent (1/b) or "b" should result.
Log-log type curve analysis can be performed on declining rate data (constant-terminal pressure case) completely analogous to the log-log type curve matching procedure presently being employed with constant-rate case pressure transient data. Production forecasting is done by extending a line drawn through the rate-time data overlain along the uniquely matched or best theoretical type curve. Future rates are then simply read from the real time scale on which the rate-time data is plotted. The ability to calculate kh from decline-curve data by type curve matching is demonstrated.
This paper demonstrates that decline-curve analysis not only has a solid fundamental base, but provides a tool with more diagnostic power than has previously been suspected. The type curve approach provides unique solutions upon which engineers can agree, or shows when a unique solution is not possible with a type curve only.
Neoadjuvant chemotherapy-induced decrease of prognostic nutrition index predicts poor prognosis in patients with breast cancer
Authors: Oba Takaaki , Maeno Kazuma , Takekoshi Daiya , Ono Mayu , Ito Tokiko , Kanai Toshiharu , Ito Ken-ichi 
Published: January 2020

Abstract
Background: The prognostic nutritional index (PNI), which is an easily calculated nutritional index, is significantly associated with patient outcomes in various solid malignancies. This study aimed to evaluate the prognostic impact of PNI changes in patients with breast cancer undergoing neoadjuvant chemotherapy (NAC). Methods: We reviewed patients with breast cancer who underwent NAC and a subsequent surgery for breast cancer between 2005 and 2016. PNI before and after NAC were calculated using the following formula: 10 × serum albumin (g/dl) + 0.005 × total lymphocyte count/mm3. The relationship between PNI and prognosis was retrospectively analyzed. Results: In total, 191 patients were evaluated. There was no significant difference in disease-free survival (DFS) between the pre-NAC PNI high group and the pre-NAC PNI low group (cutoff: 53.1). However, PNI decreased in 181 patients (94.7%) after NAC and the mean PNI also significantly decreased after NAC from 52.6 ± 3.8 pre-NAC to 46.5 ± 4.4 post-NAC (p < 0.01) . The mean ΔPNI, which was calculated as pre-NAC PNI minus post-NAC PNI, was 5.4. The high ΔPNI group showed significantly poorer DFS than the low ΔPNI group (cut off: 5.26) (p = 0.015). Moreover, high ΔPNI was an independent risk factor of DFS on multivariate analysis (p = 0.042). Conclusions: High decrease of PNI during NAC predicts poor prognosis. Thus, maintaining the nutritional status during NAC may result in better treatment outcomes in patients with breast cancer.
Icotinib is as efficacious as gefitinib for brain metastasis of EGFR mutated non-small-cell lung cancer
Authors: Liu Kejun , Jiang Guanming , Zhang Ailing , Li Zhuanghua , Jia Jun 
Published: January 2020

AbstractBackground: The prognosis of non-small-cell lung cancer (NSCLC) with brain metastases is very poor. Currently, therapeutic methods for this patient population include whole-brain radiation therapy (WBRT), surgery, radiosurgery and systemic treatment. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) could be effective on cerebral metastases of mutated NSCLC. However, which EGFR-TKIs is more appropriate is still unknown. Methods: We conducted a retrospective analysis of advanced NSCLC patients with brain metastases for EGFR targeted therapy from November 2013 to April 2018 at Dongguan People’s Hospital, Southern Medical University, China. A total of 43 patients were recruit in this study. Among them, 21 cases received icotinib (125 mg, thrice a day) and 22 cases received geﬁtinib (250 mg, once a day) until disease progression or unacceptable toxicity. The primary end point of this study was intracranial PFS (iPFS). The relationships between therapeutic arms and patients characteristics were performed using Pearson’s chi-square test or Fisher’s exact test. The differences in PFS among the two arms were analyzed using Kaplan-Meier curves and log rank tests. Results: There was no significant difference of intracranial ORR (66.6% versus 59.1%, P =0.62) and DCR (85.7% versus 81.8%, P =0.73) between the two arms. The median intracranial PFS (iPFS) for icotinib and gefitinib arms were 8.4 months (95% CI, 5.4 to 11.3 months) and 10.6 months (95% CI, 6.3 to 14.8 months), respectively (P =0.17). Adverse events of the two study arms were generally mild. None of the patients experienced dose reduction of EGFR-TKIs. Conclusions: Our study showed that icotinib and geﬁtinib had similar efficacy for brain metastasis of EGFR mutated NSCLC. Large randomized studies are suggested to further illuminate the effect of these two EGFR-TKIs on cerebral lesions of NSCLC.
Quasimetagenomic source tracking of Listeria monocytogenes from naturally contaminated ice cream
Authors: Ottesen Andrea , Ramachandran Padmini , Chen Yi , Brown Eric , Reed Elizabeth , Strain Errol 
Published: January 2020

Abstract
Background

The more quickly bacterial pathogens can be linked to a vehicle of transmission or a source, the more illnesses can be prevented. Whole genome sequencing (WGS) based approaches to source tracking have greatly increased the speed and resolution with which public health response can pinpoint the vehicle and source of outbreaks. Traditionally, WGS approaches have focused on the culture of an individual isolate before proceeding to DNA extraction and sequencing. For Listeria monocytogenes (Lm), generation of an individual isolate for sequencing typically takes about 6 days. Here we demonstrate that a hybrid, “quasimetagenomic” approach ie; direct sequencing of microbiological enrichments (first step in pathogen detection and recovery) can provide high resolution source tracking sequence data, five days earlier than response that focuses on culture and sequencing of an individual isolate. This expedited approach could save lives, prevent illnesses and potentially minimize unnecessary destruction of food.
Methods

Naturally contaminated ice cream (from a 2015 outbreak) was enriched to recover Listeria monocytogenes following protocols outlined in the Bacteriological Analytic Manual (BAM). DNA from enriching microbiota was extracted and sequenced at incremental time-points during the first 48 hours of pre-enrichment using the Illumina MiSeq platform (2 by 250), to evaluate genomic coverage of target pathogen, Listeria monocytogenes .
Results

Quasimetagenomic sequence data acquired from hour 20 were sufficient to discern whether or not Lm strain/s were part of the ongoing outbreak or not. Genomic data from hours 24, 28, 32, 36, 40, 44, and 48 of pre-enrichments all provided identical phylogenetic source tracking utility to the WGS of individual isolates (which require an additional 5 days to culture).
Conclusions

The speed of this approach (more than twice as fast as current methods) has the potential to reduce the number of illnesses associated with any given outbreak by as many as 75% percent of total cases and potentially with continued optimization of the entire chain of response, contribute to minimized food waste.