bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE OUTBREAK’S MODELING OF CORONAVIRUS (COVID-19) USING THE MODIFIED SEIR MODEL IN INDONESIA
Authors: Rustan Rustan , Handayani Linda 
Published: May 2020

Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by a new type of virus called SARS-CoV-2, and by the beginning of 2020 had spread throughout the world, including Indonesia. A high rate of spread of COVID-19 causes the number of patients that infected increase significantly. In this study, mathematical modeling was carried out to predict the number of COVID-19 patients and the duration of the COVID-19 pandemic in Indonesia. The model used is a modified SEIR model (Susceptible, Exposed, Infected, Recovered) with several assumptions such as a constant and homogeneous population, patients who have recovered can not be infected, and the spread only occurs from human to human. In addition, it is assumed that there are individuals who carry out quarantine and isolation. Modeling is done using the help of MATLAB R2015a. The modeling results show that the peak of the COVID-19 pandemic in Indonesia will occur in the middle of May 2020, and the number of infected patients will be about 15000 people. This amount can be reduced if the quarantine and self-isolation process is carried out optimally.
Tongmai Yangxin Pills Improves Cardiac Function by Enhancing the Expression of SIRT3 and PGC-1α in a Rat Model of Isoproterenol-Induced Cardiomyopathy
Authors: Zhu Zhenyu , Li Huihui , Chen Wanli , Cui Yameng , Huang Anan , Qi Xin 
Published: May 2020

Abstract
Background: Mitochondrial biosynthesis regulated by the PGC-1α-NRF1-TFAM pathway is closely related to mitochondrial function and mitochondrial reactive oxygen generation, and is considered to be a new possible therapeutic target for the treatment of heart failure.Methods: Tongmai Yangxin Pills (TMYXP) is a Chinese patent medicine for the treatment of ischemic heart disease. It has the ability to scavenge oxygen free radicals and improve the antioxidant capacity of the heart muscle, thereby protecting cardiomyocytes, however, its mechanism is not well established. In this study, to investigate the mechanisms of TMYXP in cardiac protection, a rat model of cardiomyopathy was established by continuous isoproterenol (ISO) stimulation. Changes in the rat body weight, heart weight index (HWI), echocardiography, histological staining and biochemical indicators were examined.Results: Our results suggested that TMYXP reduced myocardial remodeling, inhibited deterioration of cardiac function, and delayed HF onset in rats with ISO-induced cardiomyopathy. Meanwhile, TMYXP markedly reduced ROS production, increased the levels of antioxidant enzymes, improved function of the mitochondrial respiratory chain, and promoted ATP production in myocardial tissues. In addition, TMYXP inhibited cytochrome C (Cyt C) release in mitochondria and caspase-3 activation in cytosol, thereby reducing the apoptosis of myocardial cells. Finally, TMYXP remarkably up-regulated the mRNA and protein expression levels of SIRT3, PGC-1α, NRF1 and TFAM in myocardial cells.Conclusions: Taken together, our results suggest that TMYXP regulates mitochondrial biosynthesis mediated enhancing the expression of SIRT3 and PGC-1α, thereby improving the cardiac function in rats with ISO-induced cardiomyopathy.
Hypofractionated palliative volumetric modulated arc radiotherapy with the Radiation Therapy Oncology Group 8502 “QUAD shot” regimen for incurable head and neck cancer
Authors: Toya Ryo , Saito Tetsuo , Yamaguchi Kohsei , Matsuyama Tomohiko , Watakabe Takahiro , Matsumoto Tadashi , Yoshida Ryoji , Hirosue Akiyuki , Murakami Daizo , Orita Yorihisa , Nakayama Hideki , Oya Natsuo 
Published: May 2020

Abstract
Background: To review a single institutional experience of the Radiation Therapy Oncology Group (RTOG) 8502 “QUAD shot” regimen using volumetric modulated arc radiotherapy (VMAT) for incurable head and neck cancer (HNC).Methods: Thirty-four consecutive patients with HNC were treated with at least one cycle of the RTOG 8502 regimen. Treatment plans included the use of VMAT with 6 MV photons generated by a linear accelerator. Two daily fractions of 3.7 Gy were delivered with an interval of at least 6 h for 2 consecutive days, totaling 14.8 Gy over 4 fractions. This was repeated every 3–4 weeks for a total of three cycles. No concurrent systemic therapy was performed.Results: The number of completed cycles was 1 in 6 (18%) patients, 2 in 5 (15%), and 3 in 23 (68%). Tumor response was achieved in 29 (85%) patients and symptom relief in 20 (77%) of 26 patients. Overall response (tumor response or symptom relief) was achieved in 32 (94%) patients. All patients who received 2 or more treatment cycles achieved overall response. Median overall survival (OS) was 5.7 months. Multivariate analysis revealed that completion of all three treatment cycles was significantly associated with better OS (P = 0.002). Grade 2 toxicity was observed in four (12%) patients, but no acute Grade ≥3 or late toxicity was observed.Conclusions: The RTOG 8502 “QUAD shot” regimen using VMAT is effective for incurable HNC with highly reduced toxicity. Treatment with multiple cycles is recommended for better treatment response and/or survival.
The role of lymph node dissection in non-metastatic renal cell carcinoma with tumor thrombosis: a retrospective analysis
Authors: Ruotao Xiao , Chuxiao Xu , Guoliang Wang , Shudong Zhang , Yi Huang , Xiaofei Hou , Xiaojun Tian , Lei Zhao , Cheng Liu , Ma Lulin 
Published: May 2020

Abstract
Background

To assess therapeutic value of lymph node dissection (LND) in non-metastatic renal cell carcinoma (RCC) with tumor thrombosis (TT) and identify the prognostic factor in these population.
Methods

We retrospectively reviewed 128 patients with RCC and TT in our institution from February 2015 to January 2019. The baseline characteristics of LND and no LND group were compared. Kaplan–Meier analysis, univariable and multivariable Cox regression models were used to analyze these population.
Results

Of 128 patients, 58(45%) underwent LND and 70(55%) without LND. Patients who received LND had significantly higher cN1 rate (64% vs 37%; P = 0.004), longer operation time (357 min vs 307 min; p = 0.002) and longer hospital stay (12.6d vs 9.5d; p = 0.094) than that in no LND group. There were 102 patients (79.7%) received followed up with the median 12 months (IQR:8 ~ 19). Estimated three-year overall survival was worse in LND group (75% vs 90%; p = 0.048) but were not significantly different in subgroup of cN0 and cN1. The overall survival were not significantly different between two groups after adjustment for age, tumor size, surgical approach, tumor thrombosis level and histologic type. Non-CCRCC (HR:4.97; 95%CL:1.56 ~ 15.78; P = 0.006) and occurrence of major complication (HR:3.33; 95%CL:1.05 ~ 10.58; P = 0.041) were the predictors of worse OS while positive lymph node is the only independent predictor of worse OS (HR:5.26; 95%CL:1.28 ~ 21.66; P = 0.021) in these populations after receiving LND.
Conclusion

In this study, we confirm that LND in non-metastatic RCC with TT was not associated with a survival benefit, even we adjusted for clinic node status. Category like age, tumor size, surgical approach, tumor thrombosis level and histologic type were not a indication for LND. Lymph node positive was identified as an independent poor prognostic factor. Therefore, LND in RCC with TT should be considered as a staging procedure rather than therapeutic one.
Association of Adipocytokines with Lipid and Glycemic Profiles in Women with Normal Weight Obesity
Authors: Taheri Ehsaneh , Hosseini Saeed , Qorbani Mostafa 
Published: May 2020

Abstract
Background: Subjects with normal weight obesity (NOW) are supposed to cardiometabolic disorders. The aim of this study was to investigate the circulating levels of vaspin and leptin and their association with glycemic and lipid profiles in women with NWO compared to controlsMaterial & Methods: Forty women with BMI:18.5-24.9 kg/m2 and FM ≥ 30% as a NOW group and 30 age matched women with same BMI range and FM<30% as control group were enrolled. Anthropometric measurement, fasting serum levels of fasting blood sugar (FBS), insulin, HbA1c, lipid profiles and also, leptin and vaspin were measured. Results: The mean ± SD of age were 28.76±4.76 years in NWO group and 29.23 ± 4.50 years in controls. Subjects in NWO group had higher serum level of insulin (9.02 ± 4.75 vs.6.24 ± 2.51, p= 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30, p<0.001) and HOMA-IR (33.77 ± 20.71 vs. 23.48 ± 10.03, p=0.009) compared to the NWNO group. Serum level of vaspin was higher in NWO (34.82 pg/ml) than control group (27.72 pg/ml),(p=0.12). In NWO subjects, serum level of leptin showed positive association with FBS (r=0.45, p=0.02), insulin (r=0.51, p=0.008), and HOMA-IR (r=0.46, p= 0.02) and vaspin concentration was positively associated with insulin (r=0.36, p= 0.02) and HOMA-IR (r=0.30, p=0.06). Conclusion: We observed that women with NWO had statistically significant increased concentration of insulin and HOMA-IR index compared to the controls. Higher levels of leptin and vaspin in NWO were associated with glycemic profiles in NWO.
Comparative analysis of transcrptome profiling to identify genes involved in bulged surface of pear fruits (Pyrus bretschneideri Rehd. cv. Yuluxiangli)
Authors: Ding Baopeng , Hu Chaohui , Song Yuqin , Hao Ruijie , Feng Xinxin , Cui Tingting , Li Liulin 
Published: May 2020

Abstract
Background: Pear (Pyrus spp.) belongs to the genus Pyrus, in the family Rosaceae. Some varieties of pear fruits exhibit bulged surface, which seriously affect the quality and commodity value. In this study, we performed anatomical, physiological and transcriptomic analysis, to explore the mechanism of paclobutrazol (PBZ) on the bulged surface of pear fruits. Results: The vascular bundles of flesh were more evenly distributed and the cells arranged more compactly with smaller size. However, the auxin (IAA) content of flesh decreased significantly when treated with PBZ. Further, the GO and KEGG analysis of differentially expressed genes (DEGs) showed that auxin, phenylpropanoid metabolic pathways and transcriptional factor genes were significantly enriched on the relieved bulged surface of pear fruits. The promoter region analysis of selected DEGs showed that some genes contained auxin responded cis-elements. Conclusion: We conclude that PBZ might play a negative role in the cell division, cell elongation and vascular bundle development on bulged surface of pear fruits through the involvement of auxin related genes. This study will provide theoretical basis for the regulation of bulged surface of pear fruits by growth retardant agent.
Menopause Rating Scale: Psychometric properties of Iranian version
Authors: Jahangiry Leila , Parviz Robabeh , Mirghafourvand Mojgan , Khazaee-Pool Maryam 
Published: May 2020

Abstract
Background
To measure the severity of menopausal complaints and determine the pattern of menopause symptoms, a valid and reliable instrument is needed in health care settings for women. Menopause Rating Scale (MRS) is one of the best known instruments that were invented in response to the lack of standardized scales. This study examines it’s psychometric properties in Iran.
Methods
Participants were randomly selected from women referring to healthcare centers in Miandoab, West Azerbaijan, Iran. A total of 330 questionnaires were completed (response rate 96.9). Two sample sizes were considered for analysis in validation process. Exploratory Factor Analysis (EFA) was conducted on the first sample (n1 = 165) and confirmatory factor analysis (CFA) was done by using a second study sample (n2 = 165). The internal consistency reliability and test-retest reliability was calculated to complete psychometric properties process.
Results
EFA with Principal Component Analysis (PCA) extracted three factors explaining 75.47% cumulative variance. CFA confirmed the three-factor structure of the MRS with 11-items. All fit indices proved to be good. The relative chi-square (χ2/df) was equal to 3.686 (p < .001). The RMSEA of the model was .04 (90% CI = .105–.150). All comparative indices of the model, including Comparative Fit Index (CFI), Normed Fit Index (NFI); and Relative Fit Index (RFI) were more than .80 (.90, .87, and .80, respectively). Cronbach’s alpha for the overall scale was .931 whereas the alpha for the subscales ranged from 0.705–0.950. Intra class correlation was .91 (95% CI = .89-.93), p < 0.001.
Conclusion
This study indicates that the Persian-MRS is a valid and reliable scale. This instrument as a screening tool could be used to identify the pattern of symptoms among menopausal, peri-menopausal, and post- menopausal women in need to care and educate them on how to deal with the symptoms.
Development and evaluation of an evidence-based medicine module in the undergraduate medical curriculum
Authors: Shahrani Abeer Salem Al 
Published: May 2020

Abstract
Background:
Evidence-based medicine (EBM) is a core competence in both undergraduate and postgraduate medical curricula. However, its integration into curricula varies widely. Our study will help medical colleges develop, implement and evaluate their EBM courses. We assessed the effectiveness of workshops in improving critical appraisal skills among medical students.
Methods
A before-and-after study design without a control group was used. A 5-week short EBM module including lectures, workshops, and online search sessions was conducted with 52 fourth-year medical students during their primary healthcare course at the College of Medicine, Princess Nourah bint Abdulrahman University. Statistical analysis was performed using SPSS statistical software (version 20, SPSS Inc., Chicago, US). Parametric tests as well as Student’s paired t-test for pre- and post-test comparisons were used.
Results
Forty-nine (49) participants completed the pre- and post-training Fresno tests, and 44.9% of the participants had a GPA of 4.0 or higher. The mean Fresno test score increased from 45.63 (SD 21.89) on the pre-test to 64.49 (SD 33.31) on the post-test, with significant improvements in the following items: Searching strategies, Relevance, Internal validity, Magnitude & significance of results, Statistical values of diagnosis studies (sensitivity, specificity, and LR), Statistical values of therapy studies (ARR, RRR, and NNT), and Best study design for diagnosis and prognosis (P < 0.05).
Conclusion
This study supports that short course in EBM that is incorporated into the undergraduate curriculum especially in the clinical years might be effective in improving medical students’ knowledge and skills in EBM. However, prospective studies are necessary to assess the long-term impact of these interventions and ultimately their effectiveness for clinical decision making.
Synthesis and characterization of a silver nanoparticle-containing polymer composite with antimicrobial abilities for application in prosthetic and orthotic devices
Authors: Quintero-Quiroz Catalina , Botero Luz E , Zárate-Triviño Diana , Saldarriaga Jorge , Pérez Vera , Riano Luis Javier Cruz 
Published: May 2020

Abstract
Background:The presence of skin problems in patients using external lower limb prosthesis is recurrent. This has generated the need to develop interfaces for prosthesis with the ability to control microbial growth. Silver nanoparticles (AgNPs) have been implemented in the development of biomaterials because of their high antimicrobial activity. This article discusses the development of an AgNP-containing polymer composite with antimicrobial activity for developing prosthetic liners. Methods:AgNPs were synthesized using a photochemical method and certain physicochemical properties were characterized. Furthermore, the antimicrobial activity of AgNPs against Staphylococcus aureus ATCC 25923 and, methicillin-resistant Staphylococcus aureus (MRSA), was assessed on the basis of their minimum inhibitory concentrations (MICs). AgNPs were incorporated into a silicon elastomer to assess antimicrobial activity and certain mechanical properties of the material. Results: The maximum antimicrobial activity of the material against Staphylococcus aureus ATCC 25923 and MRSA was 41.58 % ± 2.97 % at an AgNP concentration of 32.98 μg/mL and 14.85 % ± 5.94 % at an AgNP concentration of 16.49 μg/mL, respectively. Additionally, the material exhibited tensile yield strength, rupture tensile strength, and tensile modulus of elasticity of 0.70 - 1.10, 0.71–1.06, and 0.20 - 0.30 MPa, respectively. The mechanical characteristics of the material were within the acceptable range for use in external lower limb prosthetic and orthotic interfaces. Conclusions:It was possible to incorporate the AgNPs in a silicone elastomer, finding that the composite developed presented antimicrobial activity against Staphylococcus aureus ATCC 25923 and MRSA when compared to non-AgNP material samples.
Overexpression of MYB Genes and Increased Abiotic Stress Tolerance: A Meta-Analysis.
Authors: Ma Yuanchun , Han Zhaolan , Shang Xiaowen , Shao Lingxia , Wang Ya , Zhu Xujun , Fang Wanping 
Published: May 2020

Abstract
Background: The MYB family of proteins is a large group of transcription factors found in all eukaryotes studied to date that has expanded significantly in plants where they are involved in a wide diversity of processes from development to abiotic stress responses. The overexpression of various MYB genes has been reported to improve stress tolerance in different plant species. However, due to the variety of plant species studied and the types of gene donors/recipients, along with different experimental conditions, it is difficult to interpret the roles of MYB genes in abiotic stress tolerance from published data.Result: We investigated the plant characteristics involved in cold, drought, and salt stress in MYB-overexpressing plants through the meta-analysis approach, and analyzed the degrees of influence on plant performance by experimental variables. The results show that two of the four measured plant parameters in cold-stressed plants, two of the six in drought-stressed, and four of the 13 in salt-stressed were significantly impacted by MYB overexpression by 22% or more. By contrast, only two of the 13 plant parameters were significantly impacted in non-stressed plants by 18% or more. Conclusions: These data suggest that the treatment medium, donor/recipient species, and donor type significantly influence the effects of MYB overexpression on drought stress tolerance. Under salt stress, the donor/recipient species, donor type, and stress duration all significantly affected the extent of MYB-mediated salt stress tolerance. This study compiles and analyzes the data across studies to help us understand the complex interactions that dictate the efficacy of heterologous MYB expression designed for improved abiotic stress tolerance in plants.
Analysis of clinical features and behavioral characteristics in T2DM comorbid emotional disorders: an investigation based on questionnaire and medical data
Authors: Yang Wei , Liu Min , Tian Yuan , Zhang Qianwei , Zhang Jiahua , Chen Qiaoyun , Chen Jun , Wang Xuejiao , Suo Lixia 
Published: May 2020

Abstract
Background Diabetes is a serious threat to human health. Physical torture and financial burden bring mental burden and psychological pressure to diabetic patients. The situation of diabetes management is quite severe and the assessment of mood disorders was particularly important.Methods A total of 60 diabetic patients were included into this study. Information of the study population was obtained through medical history and questionnaire survey. The participants were divided into two groups according to the results of emotional disorders assessment.Results The comparison results of basic information between the two groups showed that differences of the proportion of female, diabetic nephropathy ratio and education background were statistically significant (p = 0.001, p = 0.01 and p = 0.027). Blood pressure of the comorbidity group was significant higher than that of control group (SBP: p = 0.000, DBP: p = 0.005). HDL, creatinine and 25-dihydroxyvitamin-D level were statistically significant (p = 0.014, p = 0.011 and p = 0.011). The results of questionnaire survey showed that there were statistically significant differences in sleep quality, PSQI, smoking habit and frequency of consuming fish between the two groups (p = 0.000, p = 0.000, p = 0.032 and p = 0.000). In cognitive function assessment, we found that the percentage of people with cognitive disorders and the score of cognitive function were significantly different between the two groups (p = 0.000 and p = 0.000).Conclusions Gender, education, diabetic nephropathy, hypertension, low levels of vitamin D, diet structure, sleep disorders were associated with diabetic emotional disorders. Physicians should not focus solely on blood glucose variability, psychology and emotion of the patients also deserve attentions.
Effect of granulocyte colony stimulating factor on pregnancy rate in women with unexplained infertility after intrauterine insemination: a randomized clinical trial
Authors: Aramesh Shahintaj , Kutenaee Maryam Azizi , Najafi Fataneh , Ghafari Parvin , taghavi seyed abdolvahab 
Published: May 2020

Abstract
Background The cause of infertility has not been found in unexplained infertile patients,, and perhaps one of the possible reasons is impairment of fetal implantation, as well as the multiple role of GCSF in improving implantation and quality of blastocyst. Therefore, the aim of this study was to investigate the role of GCSF in the pregnancy rate of patients undergoing IUI.Methods The patients with unexplained infertility were divided into two groups: one group was received GCSF in their IUI cycle and the other group had the routine IUI. Both groups were stimulated by letrozole, metformin, and monotropin during the cycle. When at least one follicle was greater than 18 mm, 5000 IU hCG intramuscularly was administered for ovulation induction and IUI was performed 34–36 hours later. In intervention group, 300 ug GCSF subcutaneously administrated in two days after IUI. Biochemical pregnancy rate was evaluated two weeks after IUI and clinical pregnancy rate was identified by the presence of a gestational sac on ultrasonography 8 weeks after IUI.Results There was no significant difference in demographic and clinical characteristics between the two groups. The chemical pregnancy rate(16.3% vs 12.2%) and the clinical pregnancy rates (16.3% vs 8.3%) were improved in patients receiving GCSF compared to controls, but these differences was not significant (P = 0.56) and (P = 0.21).Conclusion Systemic administration of a single dose of 300 µg GCSF subcutaneously two days after IUI may slightly improve clinical pregnancy rate in patients with unexplained infertility. Nevertheless, our findings do not support routine use of G-CSF in unexplained infertility women with normal endometrial thickness.