bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social functioning outcomes in men and women receiving medication-assisted treatment for opioid use disorder
Authors: van Reekum Emma A. , Rosic Tea , Hudson Jacqueline , Sanger Nitika , Marsh David C. , Worster Andrew , Thabane Lehana , Samaan Zainab 
Published: April 2020

Abstract
Background
Social functioning (SF), the ability to engage with life and fulfill roles may be a salient “patient important outcome” in addiction treatment. It is not known if medication-assisted treatment (MAT) impacts SF in opioid use disorder (OUD). There is a growing evidence to suggest that men and women are impacted differently by OUD. This study is the largest to date to study sex differences in OUD and explore associations between MAT and SF.

Methods
Data were collected from 2736 participants with OUD, enrolled in MAT for varying lengths of time, in outpatient clinics across Ontario. SF was defined according to the Maudsley Addiction Profile’s domains of (1) employment, (2) criminal activity, and (3) interpersonal conflict. Using logistic regression analysis, we examined sociodemographic and clinical factors associated with domains of SF.

Results
There were 1544 men (56%) and 1192 women (44%) in this study, and ages varied from 17 to 76 years for men and 18 to 69 years for women. At study entry, participants had been on MAT for a median of 2 years. Compared to men, women reported more psychological (mean MAP score 14/40, SD = 9.55, versus 11/40, SD = 8.64; p < 0.001) and physical symptoms (mean MAP score 17/40, SD = 7.70 versus 14/40, SD = 7.74; p < 0.001). More women reported unemployment(74% versus 58%; p < 0.0001) and interpersonal conflict (46% versus 35%; p < 0.0001). Men were more likely than women to report criminal activity (11%, versus 8%; p = 0.001). Psychological symptoms increased the risk of worse SF, across domains, for men and for women. Every year on MAT was associated with a 7% increase in the odds of women engaging with criminal activity (OR = 1.07, 95% CI 1.02, 1.12, p = 0.006).

Conclusions
Men and women had different SF profiles and psychological symptoms scores while on MAT. The length of time on MAT increased the risk of criminal activity in women, and overall, duration of MAT was not associated with improvement in SF. This may suggest that MAT alone may not support continual improvements in SF in OUD.
Analytical approach for fractional extended Fisher–Kolmogorov equation with Mittag-Leffler kernel
Authors: Veeresha P. , Prakasha D. G. , Singh Jagdev , Khan Ilyas , Kumar Devendra 
Published: April 2020

AbstractA new solution for fractional extended Fisher–Kolmogorov (FEFK) equation using the q-homotopy analysis transform method (q-HATM) is obtained. The fractional derivative considered in the present work is developed with Atangana–Baleanu (AB) operator, and the technique we consider is a mixture of the q-homotopy analysis scheme and the Laplace transform. The fixed point hypothesis is considered for the existence and uniqueness of the obtained solution of this model. For the validation and effectiveness of the projected scheme, we analyse the FEFK equation in terms of arbitrary order for the two distinct cases. Moreover, numerical simulation is demonstrated, and the nature of the achieved solution in terms of plots for distinct arbitrary order is captured.
One step ahead? The use of foresight by Czech and Slovak non-governmental organizations
Authors: Šerá Komlossyová Eva , Schlossarek Martin , Macková Lucie , Medová Nikola 
Published: April 2020

AbstractNon-governmental organizations (NGOs) are generally recognized as important actors in societies, fulfilling diverse sets of roles. Given the nature of their work and the complexity of the fast-changing contexts in which they operate, foresight techniques can potentially be useful in helping them prepare for future disruptions and maximize the positive influence of their work over future developments. The possibilities for and benefits of the application of foresight approaches and techniques are increasingly being discussed in various private and public organizations, especially with the aim to innovate and grow. However, little attention has been given to the question of how NGOs use foresight and whether their work benefits from it. The paper presents results of a survey conducted among Czech and Slovak NGOs active in development cooperation, humanitarian assistance, and environmental protection fields, filling the existing research gap by analyzing their application of foresight processes and the benefits foresight brings to them. The paper concludes that future-oriented processes in Czech and Slovak NGOs are of a rather informal and non-institutionalized nature, given the insufficient knowledge of foresight concepts and limited human capacities of NGOs. Nevertheless, they positively influence their creativity and growth.
Factors influencing patient and health care delays in Oropharyngeal Cancer
Authors: Nieminen Markus , Atula Timo , Bäck Leif , Mäkitie Antti , Jouhi Lauri , Aro Katri 
Published: April 2020

Background The incidence of human papillomavirus (HPV)–associated oropharyngeal squamous cell carcinoma (OPSCC) is increasing. Patients with HPV-associated and HPV-unassociated OPSCC differ in many aspects, which may also impact their diagnostic and management timelines. This study aims at studying the patient, primary health care (PHC) and specialist-care (SC) delays and possible differences between these two patient groups in seeking medical care. Methods We reviewed all new patients with OPSCC treated between 2016 and 2018 at our institute, which covers a referral area of 1.6 million people. We collected data on patients’ symptoms and factors influencing why they sought medical care using a patient-reported questionnaire and hospital records. We compared delays based on patient and tumor characteristics. Results In our study population of 83 patients, the median patient delay was 30 days (range, 0–366), with a median PHC delay of 15 days (range, 0 days–2.5 years), and a median SC delay of 54 days (range, 12–231). The SC delay was further divided into diagnostic hospital delay and treatment delay, each with a median length of 16 days (range, 0–237) and 29 days (range, 0–73), respectively. Furthermore, we found that p16 status did not associate with delays. A longer patient delay associated with specific tumor factors, such as a larger primary tumor and a lower UICC 7th edition stage. Patients that had multiple visits or did not have a follow-up visit scheduled at the initial appointment had longer PHC delays. Treatment delay was significantly longer for patients scheduled for (chemo-)radiotherapy than for those undergoing surgery with or without (chemo-)radiotherapy. Conclusions Although delays remained short for the majority of OPSCC patients, long delays require further evaluation and improvement of management. Awareness of presenting symptoms among cancer risk patients and prompt referral practice or a follow-up visit at PHC represent key factors to shortening these delays. Ultimately, the causes for delays in SC appear multifactorial and require institutional quality control.
18F-fluorodeoxyglucose–positron emission tomography/computed tomography for the diagnosis of polymyalgia-like illnesses: a retrospective study
Authors: Horikoshi Hideyuki , Nakanishi Takashi , Tamura Katsumi , Kimura Fumihiko , Itoh Kenji 
Published: April 2020

Abstract
Background
Various inflammatory conditions may present with musculoskeletal symptoms similar to those of polymyalgia rheumatica (PMR). We investigated findings on 18F-fluorodexoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) images that may differentiate PMR from polymyalgia-like illnesses.

Methods
We analyzed data from 25 patients with new-onset polymyalgia-like illnesses who fulfilled Bird’s diagnostic criteria for PMR and had undergone FDG–PET/CT scan. To assess the uptake by major joints and synovial bursae, particularly at PMR-specific sites (shoulder, sternoclavicular, and hip joints, interspinous bursae, ischial tuberosities, and greater trochanters), we used visual scoring system to score FDG uptake: 0, no uptake (same as bone); 1, slight uptake; 2, moderate uptake (same as the liver); 3, greater uptake than the liver; and 4, uptake as strong as in the cerebellum.

Results
The final diagnoses were PMR in 17 patients and non-PMR in eight patients (three malignancies, two infections, one cholesterol crystal embolism, one ANCA-associated vasculitis, and one undefined diagnosis). Although the serum MMP-3 levels were significantly higher in patients with PMR, C-reactive protein and erythrocyte sedimentation rate mean values did not differ between the two groups. In PMR-specific sites, FDG accumulations were observed in all cases of PMR, with a high PET-positive score of 2.00 (range, 0–3), but it was low in non-PMR cases, with a PET-positive score of 1.00 (range, 0–3).

Conclusions
The FDG accumulation patterns in polymyalgia-like illness differ from those in PMR, despite the similar clinical presentations of both conditions. An FDG–PET/CT scan is useful for differentiating PMR from other polymyalgia-like illnesses.
Ancient rip current records and their implications: an example from the Cretaceous Ukra Member, Kutch, India
Authors: Sarkar Subir , Koner Amlan 
Published: April 2020

AbstractPoorly-sorted conglomerate patches rich in granules or sturdy fossils or both, and reddish mud matrix within the interstices stand out amidst fine-grained siliciclastic shelf sediments of the trangressive systems tract (TST) of the Lower Cretaceous Ukra Member, Kutch Basin, India. The siliciclastic shelf sediments contrast the conglomerates with their remarkable lateral extension. The fossils belong to a low-diversity group of sedentary bivalves that can be traced into the shoreface facies assemblage. The shelf sandstones are almost always sculpted by wave structures, especially hummocky cross-stratification while textures in the conglomerates suggest that the sediment settling was generally from suspensions. Textural variations in conglomerates reflect an immediate variation in flow viscosity prior to the downloading. The current structures obtained from the conglomerates record offshoreward palaeocurrent, in contrast to the shore-parallel palaeocurrent in the TST. The hummocky cross-stratified (HCS) beds are interpreted as seasonal storm deposits, while the conglomerate patches are taken as rip current deposits induced by waves of much longer periods. The glauconite-rich shale that alternates with conglomerates is probable fair-weather products. The conglomerates could not be recognized either in the coarse-grained shoreface deposits occupying the lower part of the overall fining-upward TST or in the coarsening-upward and glauconite-depleted highstand systems tract (HST). In contrast to the TST, the HST is dominantly tide-imprinted, having shore-normal palaeocurrent direction. It appears that intensification of waves and weakening of tides during transgression favored strong rip currents generation, which had presumably caused severe damage to the sea coast and to the shell banks growing preferably at the necks of the rip current channels. Rapid lateral facies transitions in the shoreface deposits at the basal part of the TST suggest enhanced irregularity in the coastline, possibly because of the mega cusps indented upon it. Frequency and intensity of storms enhanced during periods of global warming caused the transgression of the Early Cretaceous Ukra Sea.
The effectiveness and cost-effectiveness of integrating mental health services in primary care in low- and middle-income countries: systematic review
Authors: Cubillos Leonardo , Bartels Sophia M. , Torrey William C. , Naslund John , Uribe-Restrepo José Miguel , Gaviola Chelsea , Díaz Sergio Castro , John Deepak T. , Williams Makeda J. , Cepeda Magda , Gómez-Restrepo Carlos , Marsch Lisa A. 
Published: April 2020

Aims and methodThis systematic review examines the effectiveness and cost-effectiveness of behavioural health integration into primary healthcare in the management of depression and unhealthy alcohol use in low- and middle-income countries. Following PRISMA guidelines, this review included research that studied patients aged ≥18 years with unhealthy alcohol use and/or depression of any clinical severity. An exploration of the models of integration was used to characterise a typology of behavioural health integration specific for low- and middle-income countries.ResultsFifty-eight articles met inclusion criteria. Studies evidenced increased effectiveness of integrated care over treatment as usual for both conditions. The economic evaluations found increased direct health costs but cost-effective estimates. The included studies used six distinct behavioural health integration models.Clinical implicationsBehavioural health integration may yield improved health outcomes, although it may require additional resources. The proposed typology can assist decision-makers to advance the implementation of integrated models.
Impact on Quality of Documentation and Workload of the Introduction of a National Information Standard for Tumor Board Reporting
Authors: Ebben Kees C. W. J. , Sieswerda Melle S. , Luiten Ernest J. T. , Heijns Joan B. , van der Pol Carmen C. , Bessems Maud , Honkoop Aafke H. , Hendriks Mathijs P. , Verloop Janneke , Verbeek Xander A. A. M. 
Published: April 2020

PURPOSE Tumor boards, clinical practice guidelines, and cancer registries are intertwined cancer care quality instruments. Standardized structured reporting has been proposed as a solution to improve clinical documentation, while facilitating data reuse for secondary purposes. This study describes the implementation and evaluation of a national standard for tumor board reporting for breast cancer on the basis of the clinical practice guideline and the potential for reusing clinical data for the Netherlands Cancer Registry (NCR). METHODS Previously, a national information standard for breast cancer was derived from the corresponding Dutch clinical practice guideline. Using data items from the information standard, we developed three different tumor board forms: preoperative, postoperative, and postneoadjuvant-postoperative. The forms were implemented in Amphia Hospital’s electronic health record. Quality of clinical documentation and workload before and after implementation were compared. RESULTS Both draft and final tumor board reports were collected from 27 and 31 patients in baseline and effect measurements, respectively. Completeness of final reports increased from 39.5% to 45.4% ( P = .04). The workload for tumor board preparation and discussion did not change significantly. Standardized tumor board reports included 50% (61/122) of the data items carried in the NCR. An automated process was developed to upload information captured in tumor board reports to the NCR database. CONCLUSION This study shows implementation of a national standard for tumor board reports improves quality of clinical documentation, without increasing clinical workload. Simultaneously, our work enables data reuse for secondary purposes like cancer registration.
Open Health Imaging Foundation Viewer: An Extensible Open-Source Framework for Building Web-Based Imaging Applications to Support Cancer Research
Authors: Ziegler Erik , Urban Trinity , Brown Danny , Petts James , Pieper Steve D. , Lewis Rob , Hafey Chris , Harris Gordon J. 
Published: April 2020

PURPOSE Zero-footprint Web architecture enables imaging applications to be deployed on premise or in the cloud without requiring installation of custom software on the user’s computer. Benefits include decreased costs and information technology support requirements, as well as improved accessibility across sites. The Open Health Imaging Foundation (OHIF) Viewer is an extensible platform developed to leverage these benefits and address the demand for open-source Web-based imaging applications. The platform can be modified to support site-specific workflows and accommodate evolving research requirements. MATERIALS AND METHODS The OHIF Viewer provides basic image review functionality (eg, image manipulation and measurement) as well as advanced visualization (eg, multiplanar reformatting). It is written as a client-only, single-page Web application that can easily be embedded into third-party applications or hosted as a standalone Web site. The platform provides extension points for software developers to include custom tools and adapt the system for their workflows. It is standards compliant and relies on DICOMweb for data exchange and OpenID Connect for authentication, but it can be configured to use any data source or authentication flow. Additionally, the user interface components are provided in a standalone component library so that developers can create custom extensions. RESULTS The OHIF Viewer and its underlying components have been widely adopted and integrated into multiple clinical research platforms (e,g Precision Imaging Metrics, XNAT, LabCAS, ISB-CGC) and commercial applications (eg, Osirix). It has also been used to build custom imaging applications (eg, ProstateCancer.ai, Crowds Cure Cancer [presented as a case study]). CONCLUSION The OHIF Viewer provides a flexible framework for building applications to support imaging research. Its adoption could reduce redundancies in software development for National Cancer Institute–funded projects, including Informatics Technology for Cancer Research and the Quantitative Imaging Network.
Targeting HER2 Alterations in Non–Small-Cell Lung Cancer: A Comprehensive Review
Authors: Zhao Jing , Xia Yang 
Published: April 2020

PURPOSE HER2 is a critical gene that drives various solid tumors in addition to those of breast cancer. For example, HER2 plays a role in non–small-cell lung cancer (NSCLC). Overexpression, amplification, and point mutations in HER2 have been described in patients with NSCLC; however, the potential roles of these alterations remain unclear. METHODS We summarize the evidence regarding the distinct impacts of different HER2 aberrations on antitumor agents. Also, we update the therapeutic efficacy of HER2-targeted agents, including anti-HER2 antibodies, antibody-drug conjugates, and small-molecule tyrosine kinase inhibitors, tested in HER2-aberrant NSCLC. RESULTS Although these drugs are not yet standard treatments, certain patients may benefit from these therapies. In this review, we aim to provide an improved understanding of HER2 aberrations in NSCLC, including NSCLC biology and the impacts of each aberration on prognosis and standard treatment. We also highlight the potential of novel anti-HER2 therapies approved by regulatory bodies and those in clinical development. CONCLUSION Compared with HER2 amplification or overexpression, HER2 mutations, especially HER2 exon 20 mutations, are emerging as the most clear targetable driver for HER2-directed therapies in lung cancer. De novo and inducible HER2 pathway activation need to be differentially managed. Further investigations with new strategies are needed.
Incidence of and Factors Associated With Prolonged and Persistent Postoperative Opioid Use in Children 0–18 Years of Age
Authors: Ward Andrew , De Souza Elizabeth , Miller Daniel , Wang Ellen , Sun Eric C. , Bambos Nicholas , Anderson T. Anthony 
Published: April 2020

BACKGROUND:
Long-term opioid use has negative health care consequences. Opioid-naïve adults are at risk for prolonged and persistent opioid use after surgery. While these outcomes have been examined in some adolescent and teenage populations, little is known about the risk of prolonged and persistent postoperative opioid use after common surgeries compared to children who do not undergo surgery and factors associated with these issues among pediatric surgical patients of all ages.

METHODS:
Using a national administrative claims database, we identified 175,878 surgical visits by opioid-naïve children aged ≤18 years who underwent ≥1 of the 20 most common surgeries from each of 4 age groups between December 31, 2002, and December 30, 2017, and who filled a perioperative opioid prescription 30 days before to 14 days after surgery. Prolonged opioid use after surgery (filling ≥1 opioid prescription 90–180 days after surgery) was compared to a reference sample of 1,354,909 nonsurgical patients randomly assigned a false “surgery” date. Multivariable logistic regression models were used to estimate the association of surgical procedures and 22 other variables of interest with prolonged opioid use and persistent postoperative opioid use (filling ≥60 days’ supply of opioids 90–365 days after surgery) for each age group.

RESULTS:
Prolonged opioid use after surgery occurred in 0.77%, 0.76%, 1.00%, and 3.80% of surgical patients ages 0–<2, 2–<6, 6–<12, and 12–18, respectively. It was significantly more common in surgical patients than in nonsurgical patients (ages 0–<2: odds ratio [OR] = 4.6 [95% confidence interval (CI), 3.7–5.6]; ages 2–<6: OR = 2.5 [95% CI, 2.1–2.8]; ages 6–<12: OR = 2.1 [95% CI, 1.9–2.4]; and ages 12–18: OR = 1.8 [95% CI, 1.7–1.9]). In the multivariable models for ages 0–<12 years, few surgical procedures and none of the other variables of interest were associated with prolonged opioid use. In the models for ages 12–18 years, 10 surgical procedures and 5 other variables of interest were associated with prolonged opioid use. Persistent postoperative opioid use occurred in <0.1% of patients in all age groups.

CONCLUSIONS:
Some patient characteristics and surgeries are positively and negatively associated with prolonged opioid use in opioid-naïve children of all ages, but persistent opioid use is rare. Specific pediatric subpopulations (eg, older patients with a history of mood/personality disorder or chronic pain) may be at markedly higher risk.
Operando Time-Slicing Neutron Reflectometry Measurements of Solid Electrolyte Interphase Formation on Amorphous Carbon Surfaces of a Li-Ion Battery
Authors: Kawaura Hiroyuki , Harada Masashi , Kondo Yasuhito , Mizutani Mamoru , Takahashi Naoko , Yamada Norifumi L 
Published: April 2020

Abstract
A solid-electrolyte interphase (SEI) is widely recognized to improve the safety and durability of lithium ion batteries. In this work, we investigate the structure and chemistry of the carbon electrode and SEI in operando during two-cycle battery operation for further understanding of the electrochemical reactions, and the effect of the hysteresis using in situ neutron reflectivity (NR) and ex situ hard X-ray photoelectron spectroscopy (HAXPES). The results revealed the structural evolution of the electrode and SEI layer, such as the change in the thickness and scattering length density (SLD) in connection with the chemical composition during the lithiation/delithiation processes. Next, the HAXPES results at the point before and after the charging/discharging process revealed the change in the chemical composition of the SEI layer due to the chemical reactions on the formation/degradation. Based on the combination of these analyses, the results showed that the SLDs of the SEI layer evaluated by NR analysis were consistent with those determined by HAXPES. Concerning the difference in the first and second cycles, the structure of the amorphous carbon electrode exhibited hysteresis due to lithiation/delithiation, whereas the chemical composition of the SEI layer after charge/discharge was almost independent of the number of cycles.