bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical pharmacy services in Brazil, particularly cardiometabolic diseases: a systematic scoping review and meta-analyses
Authors: Nassur Priscila L. , Forgerini Marcela , Mastroianni Patricia C. , Lucchetta Rosa C. 
Published: November 2020

Objective: To map the clinical pharmacy services conducted in Brazil, their characteristics, outcomes, and process measures in general population, as well as the assessment of the clinical impact on people with cardiometabolic diseases (cardiovascular diseases and metabolic diseases).
Methods: A systematic scoping review and meta-analysis were conducted. The electronic searches were re-run in March 2020. To the clinical impact assessment, meta-analyses of cardiometabolic outcomes (i.e., change of systolic (SBP) and diastolic blood pressure (DBP), triglycerides, total cholesterol, glycated hemoglobin (HbA1c), fasting glycemia, LDL-, and HDL-cholesterol) were led. The risk of bias was assessed with the Cochrane Collaboration tools.
Results: 71 studies were identified (7,402 patients), being the majority quasi-experimental studies (n=41) and published by research groups of Southeast Brazil (n=33). Medication therapy management (n=62) was the most frequent clinical pharmacy service, performed on outpatient setting (n=45), with adults or elderly people (n=58) with hypertension (n=18) or diabetes (n=10). Process measures (n=58) (e.g. resolution of drug related-problem) were widely used as indicator, followed by clinical (n=44) (e.g. change in SBP), humanistic (n=12) (e.g. change in quality-of-life score assessed by Short-Form 36 Health Survey Questionnaire), and economic outcomes (n=3) (incremental cost-effectiveness ratio for reduction in HbA1c). Regarding the assessment of clinical impact of the services, 20 studies were included in meta-analyses, showing improvement in most cardiometabolic outcomes when considered individual studies. However, the evidence presents high risk of bias, high heterogeneity (median 67-90%) and imprecision, contributing to wide prediction intervals and low reliability.
Conclusions: A predominance of studies on cardiometabolic diseases, process measures, and clinical outcomes were identified. Considering the assessment of the clinical impact of clinical pharmacy services in cardiometabolic diseases, an improvement in most cardiometabolic outcomes was showed, however, with low confidence and wide prediction interval. Therefore, development of larger studies with low risk of bias and major homogeneity is necessary for a better comprehension of clinical pharmacy service characteristics, benefits, and the population groups most benefited.
Iatrogenic Compartment Syndrome After Delayed Primary Closure of the Tibial Fracture–Related Leg Fasciotomy Wound
Authors: Karamian Brian A. , Bishop Julius A. 
Published: November 2020

Case:
Compartment syndrome can occur after tibial fracture and requires prompt diagnosis and immediate fasciotomy. Because of post-traumatic swelling, delayed primary wound closure can be difficult requiring significant tension on the skin. Closing the skin in this setting theoretically puts the patient at risk of elevated compartment pressures, although compartment syndrome has never been reported in these circumstances. We describe a case of compartment syndrome that developed after delayed primary skin closure of a single incision 4-compartment fasciotomy wound after tibial fracture.

Conclusion:
This is the first published description of compartment syndrome after delayed primary closure of a leg fasciotomy wound.
Total Hip Arthroplasty to Treat Chronic Native Hip Obturator Dislocation
Authors: Bounajem Georges J. , Maier Stephen P. , Smith Evan , Heng Marilyn , Melnic Christopher M. 
Published: November 2020

Case:
A 37-year-old woman presented with a rare chronic dislocation of her native right hip where the head of the femur was incarcerated in the obturator foramen of her pelvis. After optimization of sociomedical factors, she underwent successful total hip arthroplasty.

Conclusion:
Total hip arthroplasty is a viable treatment option for the chronic incarcerated obturator hip dislocation.
Proyeksi Ekspor Beras Nasional Melalui Gerakan Tiga Kali Lipat Ekspor (Gratieks) Pertanian Indonesia
Authors: Sa’diah Siti Aminatus , Tamami Novi Diana Badrut 
Published: November 2020

Indonesia memiliki neraca perdagangan beras yang selalu negatif, artinya impor beras jauh lebih tinggi dari ekspornya. Merujuk pada strategi dan target Kementerian Pertanian Kabinet Indonesia Maju, pemerintah menggalakan kebijakan Gerakan Tiga Kali Lipat Ekspor (Gratieks) oleh petani dan pengusaha. Tujuan penelitian ini adalah untuk: (1) mengetahui perkembangan produksi, konsumsi, dan impor beras di Indonesia pada tahun 1999-2018, serta (2) mengetahui proyeksi ekspor beras Indonesia pada tahun 2019-2023 dengan metode forecasting Moving Average, Double Exponential Smoothing, dan ARIMA terhadap data ekspor tahun 1999-2018. Hasil peramalan menunjukkan bahwa permodelan terbaik adalah ARIMA ordo tentatif p,d,q 101 dengan MAPE 0,94. Berdasarkan target pemerintah tentang tiga kali lipat ekspor dari tahun 2018, masih terdapat marjin yang harus dicapai untuk memenuhi target dengan asumsi kebijakan yang diterapkan sama dengan yang berlaku sebelumnya.
Pelatihan Pengolahan Granul Instan Jahe Emprit dan Kapulaga Bagi Tim PKK Desa Kaliputih Kabupaten Banyumas
Authors: Syarifah Arini , Hariyanti Hariyanti , Inayati Nur Isna 
Published: November 2020

Jahe emprit dan kapulaga merupakan hasil pertanian para petani di desa Kaliputih kecamatan Purwojati kabupaten Banyumas. Jahe emprit merupakan komoditi hasil pertanian yang minoritas di desa kaliputih. Kapulaga dan jahe emprit juga hanya sebatas dijual dalam bentuk utuh tanpa proses pengolahan apapun. Oleh karena itu perlu adanya pelatihan pengolahan kombinasi jahe emprit dan kapulaga menjadi granul instan bertujuan untuk meningkatkan nilai jual dari kedua bahan tersebut. Ibu rumah tangga yang tergabung dalam Tim PKK desa Kaliputih merupakan mitra sasaran dalam pengabdian ini. Ibu rumah tangga merupakan segmentasi massa dengan peluang besar dalam pengolahan granul instan jahe emprit dan kapulaga dikarenakan rata-rata ibu-ibu di desa kaliputih menjadi ibu rumah tangga. Dari hasil pengabdian ini terjadi peningkatan pengetahuan dan ketrampilan Tim PKK desa Kaliputih dalam pengolahan jahe emprit dan kapulaga menjadi granul instan. Sehingga bisa disimpulkan Tim PKK desa Kaliputih sudah terlatih dalam pembuatan granul instan jahe emprit dan kapulaga.
Insights into the cultured bacterial fraction of corals
Authors: Sweet Michael , Villela Helena , Keller-Costa Tina , Costa Rodrigo , Romano Stefano , Bourne David , Cardenas Anny , Huggett Megan , Kerwin Allison , Kuek Felicity , Medina Monica , Meyer Julie , Müller Moritz , Pollock Joseph , Rappé Michael , Sere Mathieu , Sharp Koty , Voolstra Christian , Ziegler Maren , Peixoto Raquel 
Published: November 2020

Abstract
Bacteria associated with coral hosts are diverse and abundant, with recent studies suggesting involvement of these symbionts in host resilience to anthropogenic stress. Despite the putative importance of bacteria, the work dedicated to culturing coral-associated bacteria has received little attention. Combining published and unpublished data, here we report a comprehensive overview of the diversity and function of culturable, coral-associated bacteria. A total of 3055 isolates from 52 studies were considered by our meta-survey. Of these, 1045 had full length 16S rRNA gene sequences, spanning 138 formally described and 12 putatively novel bacterial genera across the Proteobacteria, Firmicutes, Bacteroidetes, and Actinobacteria phyla. We performed comparative genomic analysis using the available genomes of 74 strains and identified potential signatures of beneficial bacterial-coral symbioses among them. Our analysis revealed >400 biosynthetic gene clusters that underlie the biosynthesis of antioxidant, antimicrobial, cytotoxic, and other secondary metabolites. Moreover, we uncovered genomic features - not previously described for coral-bacterial symbioses - involved in host colonization and host-symbiont recognition, antiviral defence mechanisms, and/or integrated metabolic interactions, which we suggest as novel targets for the screening of coral probiotics. Our results highlight the importance of bacterial cultures to elucidate coral holobiont functioning, and guide the selection of probiotic candidates to promote coral resilience and improve reef restoration efforts.
Age-related clonal haematopoiesis is more prevalent in older adults with HIV: the ARCHIVE study
Authors: Dawson Mark , Dharan Nila , Yeh Paul , Bloch Mark , Yeung Miriam , Baker David , Guinto Jerick , Roth Norman , Ftouni Sarah , Ognenovska Katherine , Smith Don , Hoy Jennifer , Woolley Ian , Pell Catherine , Templeton David , Fraser Neil , Rose Nectarios , Hutchinson Jolie , Petoumenos Kathy , Dawson Sarah-Jane , Polizzotto Mark 
Published: November 2020

Abstract
People with HIV have higher rates of certain comorbidities, particularly cardiovascular disease and some malignancies, than people without HIV. As somatic mutations associated with age related clonal haematopoiesis (CH) are linked to similar comorbidities in the general population, we hypothesized that CH may be more prevalent in people with HIV. To address this issue, we established a prospective cohort study recruiting 220 HIV-positive and 226 HIV negative participants aged 55 years or older in Australia. Demographic characteristics, clinical data and peripheral blood were collected to assess for the presence of CH mutations and identify potential risk factors for and clinical sequelae of CH. Investigators testing for CH were blinded to participants’ HIV status. In total, 132 CH mutations were identified in 99 (22.2%) of 446 participants. CH was more prevalent in HIV-positive participants than HIV-negative
participants (27.7% vs. 16.8%, p =0.006), overall and across all age groups. HIV infection was associated with an increased odds of having CH (adjusted odds ratio 2.10, 95% confidence interval 1.30-3.38, p=0.002). The most common genes mutated were DNMT3A (48.5%), TET2(20.5%) and ASXL1 (11.4%). CH and HIV infection were independently associated with increases in blood parameters and biomarkers associated with inflammation. These data suggest a selective advantage for the emergence of CH in the context of chronic infection and inflammation related to HIV infection.
Nontuberculous Mycobacterial Endophthalmitis: Case Series and Review Literature
Authors: Pinitpuwadol Warinyupa , Tesavibul Nattaporn , Boonsophon Sutasinee , Sakiyalak Darin , Sarunket Sucheera , Choopong Pitipol 
Published: November 2020

Abstract
Background: To report three cases of nontuberculous mycobacterial (NTM) endophthalmitis following multiple ocular surgeries and to review previous literature in order to study the clinical profile, treatment modalities, and visual outcomes among patients with NTM endophthalmitis.Methods: Clinical manifestation and management of patients with NTM endophthalmitis in the Department of Ophthalmology, Faculty of Medicine, Siriraj hospital, Mahidol University, Bangkok, Thailand were described. In addition, a review of previously reported cases and case series from MEDLINE, EMBASE, and CENTRAL was performed. The clinical information and type of NTM from the previous studies and our cases were summarized.Results: We reported three cases of NTM endophthalmitis caused by M. haemophilum, M. fortuitum and M. abscessus and a summarized review of 112 additional cases previously published. Of 115 patients, there were 101 exogenous endophthalmitis (87.8%) and 14 endogenous endophthalmitis (12.2%). The patients’ age ranged from 13 to 89 years with mean of 60.5±17.7 years with no gender predominance. Exogenous endophthalmitis occurred in both healthy and immunocompromised hosts, mainly caused by cataract surgery (67.3%). In contrast, almost all endogenous endophthalmitis patients were immunocompromised. Among all patients, previous history of tuberculosis infection was identified in 4 cases (3.5%). Rapid growing NTMs were responsible for exogenous endophthalmitis, while endogenous endophthalmitis were commonly caused by slow growers. Treatment regimens consisted of macrolides, fluoroquinolones or aminoglycosides, which were continued for up to 12 months. Initial and final vision were generally worse than 6/60.Conclusions: NTM endophthalmitis is a serious intraocular infection that leads to irreversible loss of vision. The presentation can mimic a chronic recurrent or persistent intraocular inflammation. History of multiple intraocular surgeries or immune-deficiency in patient with chronic panuveitis should raise the practioner’s suspicion of NTM endophthalmitis. Appropriate diagnosis and treatment are important to optimize visual outcome.
Clinical characteristics of 10 children with COVID-19 outside of Wuhan in Hubei Province
Authors: Chen Ming , Fan Panpan , Liu Zhi , Li Junhua , Huang Shaowu , Wu Wanwan , Pan Rui , Zhao Dongchi 
Published: November 2020

Abstract
Background：An outbreak of coronavirus disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) began in Wuhan, Hubei Province, China in December 2019. This study aims to report the clinical characteristics of children COVID-19 in Xiangyang, a city outside of Wuhan within Hubei Province.Methods：We retrospectively investigated the clinical manifestations, Chest CT imaging, and laboratory characteristics of confirmed cases of children with COVID-19 with WHO interim guidance in Xiangyang Central Hospital from Feb 1 to Mar 10, 2020. 10 children cases were confirmed by real-time RT-PCR and were analyzed for epidemiological, demographic, clinical, radiological features and laboratory data. Outcomes were followed up until Mar 10, 2020.Results：6 cases (60%) had never been to Wuhan but closely contacted with family members with confirmed COVID-19, and 4 cases (40%) had made short term trips to Wuhan alone without familial clustering. The most common symptoms were cough (50%) followed by fever (40%), 4 cases (40%) showed asymptomatic characteristics including 2 cases (20%) with abnormal chest computed tomograms (CT) image. 9 cases (90%) were mild type, only 1 case (10%) was moderate type, none of them progressed in severe or critical disease. 4 (40%) cases showed leucopenia but none lymphopenia. Abnormalities on chest CT were detected among 8 cases (80%), 2 of 4 cases without obvious symptoms had abnormal chest CT.Conclusions: Children's infection is mainly caused by family clusters. No transmission to other individuals from children was found in our observation. The clinical manifestations in children with COVID-19 are non-specific with milder symptoms and good outcomes.
Participatory analysis of sustainable land and water management practices for integrated rural development in Myanmar
Authors: Castelli Giulio , Oo Win Min , di Maggio Andrea , Fellin Lorenzo , Re Viviana , Bresci Elena 
Published: November 2020

Abstract
Besides providing reliable water resources for agricultural production, rural development efforts in Myanmar should target rural water security in terms of safe water supply and sanitation, and by mitigating water-related hazards. However, very few studies are available over the status of water-related development in rural areas of the country, and consequently on suitable practical solutions. The present paper describes a participatory workshop undertaken involving 45 rural development officers of the Department of Rural Development (DRD) of the Ministry of Agriculture, Livestock and Irrigation (MOALI), aimed at identifying suitable sustainable land and water management (SLWM) practices to be developed in rural areas of the country. Adoption of water safety plans (WSP), water harvesting, and soil and water bioengineering were strongly supported, while the need for improving water sanitation, especially in the poorest areas, was made evident. Insights of the participatory process confirmed that the poorest regions of Myanmar have also the worst water management structures. The results of the present work can represent baseline information and a needs assessment for future development projects in the country. However, there is a strong need for more studies and reports targeting marginalized rural contexts of Myanmar, to support equitable development.
Water saving potential and economic viability assessment of rainwater harvesting system for four different climatic regions in China
Authors: Shiguang Chen , Yu Zhang 
Published: November 2020

Abstract
Rainwater is one of the most promising alternative water sources. However, the financial outcomes of the rainwater harvesting (RWH) systems are not always assured as economic performance of RWH systems vary greatly under different climatic conditions.This paper investigates reliability, water saving and benefit-cost ratio of an RWH system with different storage tanks and under three distinct climatic conditions (i.e., wet, average and dry year) at four cities in China. It was found that for a standard building (1,600 m2 roof having 560 people), the rainwater supply reliability varies significantly (3.85–20.55%) across four cities. It was found that Guangzhou (South China) always achieves the highest reliability, greatest annual water saving and highest benefit-cost ratio under three distinct climate conditions. By contrast, Beijing (North China) is mostly ranked as having the lowest one. These findings are well in line with the historical annual precipitation in these regions. Also, it was found that across these four regions, it was not possible for a RWH system to achieve a benefit-cost ratio higher than 1.0. These findings indicate that the RWH systems in most regions of China are currently economically unfeasible without government subsidies.
Pertanggungjawaban dan Penyelesaian Sengketa Konsumen Berkaitan Dengan Perdagangan Parsel
Authors: Diyatmika Kadek Purwa Sastra , Widiati Ida Ayu Putu , Karma Ni Made Sukaryati 
Published: November 2020

Abstrak—Perindungan konsumen ini adalah jaminan yang seharusnya di dapat oleh para konsumen atas setiap produk bahan makanan yang dibeli dari produsen atau pelaku usaha. Bagi pelaku usaha yang hanya selalu mementingkan bagaimana memperoleh keuntungan yang banyak tanpa memikirkan kepentingan konsumen. Dapatlah diajukan beberapa permasalahan yang akan merupakan pokok bahasan dari penelitian ini, permasalah tersebut yaitu: 1) Bagaimanakah bentuk pertanggungjawaban dalam hal terjadi kerugian pada konsumen akibat mengkonsumsi produk dalam parsel. 2) bagaimanakah mekanisme penyelesaian sengketa konsumen yang menimbulkan akibat kerugian mengkonsumsi produk dalam parsel. Penyajian ini menggunakan metode penelitian hukum empiris, pendekatan masalah secara sosiologis yaitu menggunakan pendekatan berdasarkan ketentuan hukum dan perkembangan hukum secara periodik. Pertanggungjawaban dalam hal terjadinya kerugian pada konsumen akibat mengkonsumsi produk dalam parsel adalah pihak – pihak yang melakukan kesalahan dan menyebabkan terjadinya kerugian. Pihak – pihak itu adalah produsen, pelaku usaha parsel dan jasa pengiriman. Sanksi menurut hukum perdata yaitu ganti rugi atau sanksi administratif dan menurut hukum pidana yaitu sanksi pidana kurungan 5 tahun penjara. Mekanisme penyelesaian sengketa konsumen yang menimbulkan kerugian akibat mengkonsumsi produk dalam parsel dapat dilakukan secara litigasi atau non litigasi. Dalam perdagangan parsel diharapkan semua pihak mengetahui tentang tanggung jawabnya masing-masing sehingga tidak akan timbul kerugian terhadap konsumen yang mengkonsumsi parsel.
Pelaksanaan Tanggung Jawab Sosial Perusahaan Pada BPR di Kabupaten Badung
Authors: Pramana I Putu Bayu , Arjaya I Made , Arini Desak Gede Dwi 
Published: November 2020

Abstrak—Perusahaan merupakan suatu wadah yang bertujuan besar untuk meningkatkan taraf kehidupan masyarakat. Dalam pengembangannya pada sektor ekonomi dan bisnis peran perusahaan dalam hal meningkatkan perekonomian Negara merupakan suatu tanggung jawab dari setiap perusahaan, dalam hal ini disebut tanggung jawab sosial perusahaan (CSR). Dalam penelitian ini memfokuskan penerapan CSR pada BPR di Kabupaten Badung yang mana BPR ini diharapkan mampu mensejahterakan masyarakat sekitar dan menjalankan amanat PERDA Kabupaten Badung No 6 Tahun 2013 tentang Tanggung Jawab Sosial Perusahaan. Dari latar belakang tersebut dapat dirumuskan dua permasalahan yaitu : 1). Bagaimana pengaturan tangung jawab sosial (CSR) pada rencana kegiatan tahunan BPR di Kabupaten Badung? 2). Bagaimana pelaksanaan rencana kegiatan tahunan yang mengatur tanggung jawab sosial (CSR) pada BPR di Kabupaten Badung ? metode yang digunakan yaitu metode penelitian empiris, yang mana penelitian secara langsung kelapangan. Hasil dari ini yaitu tanggung jawab sosial merupakan komitmen perusahaan dalam meningkatkan perekonomian masyarakat yang bermanfaat bagi perusahaan dan masyarakat umum yang dimana pengaturan tanggung jawab sosial perusahaan pada BPR di Kabupaten Badung yaitu UU No 40 Tahun 2007 Tentang Perseroan Terbatas, PP No 47 Tahun 2012, dan Peraturan Daerah Kabupaten Badung No 6 Tahun 2013. Dalam pelaksanaannya tanggung jawab sosial (CSR) pada BPR di Kabupaten Badung sudah berjalan baik seperti dalam hal pendidikan pemberian beasiswa kepada siswa/siswi yang berprestasi dan pengenalan produk perbankan kepada masyarakat setempat.
Asas Itikad Baik dalam Perjanjian Jual Beli Barang Melalui Media Elektronik (E-Commerce)
Authors: Putra I Wayan Agus Grahadi , Budiartha I Nyoman Putu , Ujianti Ni Made Puspasutari 
Published: November 2020

Abstak—Perkembangan teknologi sangat mempengaruhi semua aspek kehidupan sekarang yang membuat kehidupan semakin instan atau lebih mudah. Salah satu aspek yang terpengaruh dari teknologi ini adalah perjanjian jual beli. Perjanjian ini awalnya dilakukan dengan pertemuan pelaku usaha dengan pembeli pada sebuah tempat (pasar), jaman sekarang perjanjian ini bisa dilakukan hanya dengan menggunakan handphone yang memiliki internet kita sudah dapat melakukan transaksi jual beli yang dinamakan E-Commerce. Adapun rumusan masalah 1. Bagaimana Keabsahan Perjanjian Jual Beli Barang menggunakan Media Elektronik (E-Commerce) bagi para pihak yang membuatnya? Bagaimana Asas Itikad Baik dalam Perjanjian Jual Beli Barang menggunakan Media Elektronik (E-Commerce)? Penelitian ini menggunakan metode penelitian normative. Hasil dari penelitian ini adalah Pengaruh E-Commerce ini telah merubah cara seseorang untuk bertransaksi di media elektonik yang membawa dampak positif bagi kedua pihaknya. Bila terdapat dampak positif maka tentunya terdapat dampak negatif yang ditimbulkan, dampak negatifnya para pelaku usaha sering kali melakukan penipuan dalam transaksi karena mereka tidak bertemu secara langsung hanya bertemu di dunia maya saja. Maka dalam dunia E-Commerce pentingnya penerapan itikad baik sangat mempengarui jalannya suatu usaha karena bila telah mempergunakan itikad baik kedua belah pihak akan tidak melakukan penipuan satu sama lainya.